gene_id Sample_name Read_count FPKM Gene Length NR GI NR ID NR Score NR Evalue NR Description NT GI NT ID NT Score NT Evalue NT Description KO ID KO Name KO Description Http Link Swissprot ID Swissprot Score Swissprot Evalue Swissprot Description PFAM ID PFAM description Gene Ontology Biological Pathway BP Description Gene Ontology Molecular Function MF Description Gene Ontology Cellular Component CC Description KOG ID KOG Description Cluster-10006.0 BF_2 8.00 0.40 1130 290463025 ADD24560.1 165 5.4e-09 Heat shock protein homolog [Lepeophtheirus salmonis]>gi|290561282|gb|ADD38043.1| Heat shock protein homolog [Lepeophtheirus salmonis] -- -- -- -- -- -- -- -- -- P82147 153 5.5e-09 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-10011.0 BF_2 1.00 0.77 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10022.0 BF_2 3.00 0.34 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10031.0 BF_2 13.00 2.82 480 209156424 3C1B 410 8.9e-38 Chain B, The Effect Of H3 K79 Dimethylation And H4 K20 Trimethylation On Nucleosome And Chromatin Structure>gi|209156428|pdb|3C1B|F Chain F, The Effect Of H3 K79 Dimethylation And H4 K20 Trimethylation On Nucleosome And Chromatin Structure 585687860 XM_006820510.1 173 1.38555e-83 PREDICTED: Saccoglossus kowalevskii histone H4-like (LOC102800779), mRNA K11254 H4 histone H4 http://www.genome.jp/dbget-bin/www_bget?ko:K11254 P62790 361 1.8e-33 Histone H4 OS=Sterkiella nova PE=3 SV=2 PF02291//PF00125//PF02969 Transcription initiation factor IID, 31kD subunit//Core histone H2A/H2B/H3/H4//TATA box binding protein associated factor (TAF) GO:0006352//GO:0006334 DNA-templated transcription, initiation//nucleosome assembly GO:0046982//GO:0003677 protein heterodimerization activity//DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-10037.0 BF_2 14.00 0.84 984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10039.0 BF_2 6.00 0.32 1066 156539833 XP_001600606.1 148 4.8e-07 PREDICTED: MD-2-related lipid-recognition protein-like, partial [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10052.0 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10055.0 BF_2 9.00 0.55 975 817196472 XP_012273824.1 505 1.7e-48 PREDICTED: uncharacterized protein LOC105696163 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-10057.0 BF_2 4.95 0.51 689 342326382 AEL23106.1 662 7.7e-67 hnRNP protein [Cherax quadricarinatus] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 457 1.9e-44 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF08777//PF00076//PF09726 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0016021 integral component of membrane KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-10078.0 BF_2 3.00 0.37 627 795132708 XP_011834745.1 961 1.5e-101 PREDICTED: 60S ribosomal protein L18 isoform X4 [Mandrillus leucophaeus] 394995139 NM_000979.3 627 0 Homo sapiens ribosomal protein L18 (RPL18), transcript variant 1, mRNA K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q07020 962 4.7e-103 60S ribosomal protein L18 OS=Homo sapiens GN=RPL18 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1714 60s ribosomal protein L18 Cluster-10081.1 BF_2 5.00 0.35 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10083.0 BF_2 8.00 1.13 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10087.0 BF_2 4.00 0.46 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10098.0 BF_2 2.00 0.52 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10108.0 BF_2 2.00 0.34 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10109.0 BF_2 3.00 0.84 436 675304841 AIL82425.1 357 1.1e-31 UNVERIFIED: ribosomal protein L35, partial [Mytilus trossulus] 241167594 XM_002410061.1 85 1.03645e-34 Ixodes scapularis ribosomal protein L35, putative, mRNA K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 P42766 339 5.7e-31 60S ribosomal protein L35 OS=Homo sapiens GN=RPL35 PE=1 SV=2 PF06839//PF00831//PF01370 GRF zinc finger//Ribosomal L29 protein//NAD dependent epimerase/dehydratase family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735//GO:0050662//GO:0003824 zinc ion binding//structural constituent of ribosome//coenzyme binding//catalytic activity GO:0005622//GO:0005840 intracellular//ribosome KOG3436 60S ribosomal protein L35 Cluster-10118.0 BF_2 5.00 0.47 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00956 Nucleosome assembly protein (NAP) GO:0006334 nucleosome assembly -- -- GO:0005634 nucleus -- -- Cluster-10121.0 BF_2 9.91 0.37 1404 342326191 AEL23011.1 612 9.9e-61 reticulon-1 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- Q6IFY7 513 1.2e-50 Reticulon-1-A OS=Xenopus laevis GN=rtn1-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1792 Reticulon Cluster-10123.0 BF_2 2.00 0.75 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10124.1 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10131.0 BF_2 2.00 0.56 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10132.0 BF_2 2.00 0.35 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10139.0 BF_2 2.00 3.26 294 325303048 DAA34261.1 251 1.5e-19 TPA_inf: hypothetical secreted protein 55 [Amblyomma variegatum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10143.0 BF_2 1.00 0.59 354 121511992 ABM55447.1 284 2.7e-23 ribosome-associated membrane protein [Xenopsylla cheopis] -- -- -- -- -- -- -- -- -- Q3T073 257 1.5e-21 Stress-associated endoplasmic reticulum protein 2 OS=Bos taurus GN=SERP2 PE=3 SV=1 PF06624 Ribosome associated membrane protein RAMP4 -- -- -- -- GO:0005783 endoplasmic reticulum KOG3491 Predicted membrane protein Cluster-10151.0 BF_2 2.00 0.39 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10153.0 BF_2 1.00 0.87 327 241602464 XP_002405189.1 254 7.4e-20 signal peptidase 12kDa subunit, putative [Ixodes scapularis]>gi|215500573|gb|EEC10067.1| signal peptidase 12kDa subunit, putative, partial [Ixodes scapularis] -- -- -- -- -- K12946 SPCS1 signal peptidase complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12946 Q9VAL0 208 6.6e-16 Signal peptidase complex subunit 1 OS=Drosophila melanogaster GN=Spase12 PE=1 SV=2 PF05038//PF06645//PF06305 Cytochrome Cytochrome b558 alpha-subunit//Microsomal signal peptidase 12 kDa subunit (SPC12)//Protein of unknown function (DUF1049) GO:0006465 signal peptide processing GO:0008233//GO:0020037 peptidase activity//heme binding GO:0005887//GO:0016021//GO:0005787 integral component of plasma membrane//integral component of membrane//signal peptidase complex KOG4112 Signal peptidase subunit Cluster-10159.0 BF_2 12.80 0.39 1646 546680629 ERL90867.1 1258 1.4e-135 hypothetical protein D910_08212 [Dendroctonus ponderosae] -- -- -- -- -- K11418 HDAC11 histone deacetylase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11418 Q9GKU5 991 5.4e-106 Histone deacetylase 11 OS=Macaca fascicularis GN=HDAC11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1344 Predicted histone deacetylase Cluster-10161.0 BF_2 2.00 0.39 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10163.0 BF_2 10.70 0.35 1578 478263408 ENN81779.1 673 9.4e-68 hypothetical protein YQE_01839, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10172.0 BF_2 6.00 0.34 1024 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10173.0 BF_2 3.00 0.52 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10180.0 BF_2 2.00 0.38 510 330976894 AEC48730.1 797 1.3e-82 ubiquitin-conjugating enzyme E2 b [Eriocheir sinensis] 379324149 JQ011379.1 430 0 Scylla paramamosain ubiquitin-conjugating enzyme E2 (UCE) mRNA, partial cds K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P25867 781 3.7e-82 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=eff PE=2 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-10197.0 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10202.0 BF_2 1.00 1.87 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10207.0 BF_2 3.00 0.72 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10212.0 BF_2 3.00 0.40 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10217.1 BF_2 4.00 0.48 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10230.0 BF_2 7.00 1.71 458 114153130 ABI52731.1 526 3.0e-51 40S ribosomal protein S24 [Argas monolakensis] 807023747 XM_004522583.2 43 2.43391e-11 PREDICTED: Ceratitis capitata 40S ribosomal protein S24 (LOC101450348), transcript variant X2, mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 468 6.6e-46 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282 Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3424 40S ribosomal protein S24 Cluster-10237.0 BF_2 2.00 0.31 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10238.0 BF_2 3.00 0.33 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10244.0 BF_2 5.00 0.57 657 241829658 XP_002414770.1 346 3.2e-30 brahma/SWI2-related protein BRG-1 [Ixodes scapularis]>gi|215508982|gb|EEC18435.1| brahma/SWI2-related protein BRG-1 [Ixodes scapularis] 347966576 XM_321283.5 36 2.77681e-07 Anopheles gambiae str. PEST AGAP001786-PA (AgaP_AGAP001786) mRNA, complete cds K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 287 9.2e-25 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-10256.0 BF_2 7.00 2.78 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10257.0 BF_2 3.00 3.20 315 241786069 XP_002414442.1 574 5.6e-57 serine/threonine protein phosphatase, putative [Ixodes scapularis]>gi|215508653|gb|EEC18107.1| serine/threonine protein phosphatase, putative [Ixodes scapularis] 220955557 FJ636063.1 118 3.28015e-53 Synthetic construct Drosophila melanogaster clone BS08023 encodes mts-RA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 Q0P594 565 2.5e-57 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Bos taurus GN=PPP2CB PE=1 SV=1 -- -- GO:0006470 protein dephosphorylation GO:0004721 phosphoprotein phosphatase activity -- -- KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-10260.0 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10262.0 BF_2 12.75 0.44 1513 642918650 XP_008191522.1 1625 3.6e-178 PREDICTED: histamine-gated chloride channel isoform X1 [Tribolium castaneum] 462305122 APGK01049251.1 114 2.87498e-50 Dendroctonus ponderosae Seq01049261, whole genome shotgun sequence K05195 GLRA3 glycine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K05195 Q91XP5 588 2.7e-59 Glycine receptor subunit alpha-3 OS=Mus musculus GN=Glra3 PE=2 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-10265.0 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10269.0 BF_2 3.00 0.66 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10273.0 BF_2 3.00 0.60 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02932//PF03419//PF13965//PF01080//PF15686 Neurotransmitter-gated ion-channel transmembrane region//Sporulation factor SpoIIGA//dsRNA-gated channel SID-1//Presenilin//Lysine-rich CEACAM1 co-isolated protein family GO:0033227//GO:0006811//GO:0043123//GO:0045766//GO:0006508//GO:0030436//GO:0043066//GO:0015931 dsRNA transport//ion transport//positive regulation of I-kappaB kinase/NF-kappaB signaling//positive regulation of angiogenesis//proteolysis//asexual sporulation//negative regulation of apoptotic process//nucleobase-containing compound transport GO:0051033//GO:0004190 RNA transmembrane transporter activity//aspartic-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-10277.0 BF_2 17.00 0.35 2343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-10285.0 BF_2 1.00 0.45 378 871248769 XP_005103573.2 229 6.9e-17 PREDICTED: scavenger receptor class B member 1-like [Aplysia californica] -- -- -- -- -- K12384 SCARB2, LIMP2, CD36L2 lysosome membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12384 Q14108 210 4.5e-16 Lysosome membrane protein 2 OS=Homo sapiens GN=SCARB2 PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-10286.0 BF_2 15.00 0.31 2329 514258350 AGO46415.1 1179 2.9e-126 succinate dehydrogenase complex subunit A, partial [Reticulitermes flavipes] 699631991 XM_009909805.1 249 4.01298e-125 PREDICTED: Picoides pubescens succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), mRNA K00235 SDHB, SDH2 succinate dehydrogenase (ubiquinone) iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00235 P21914 1121 6.4e-121 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Drosophila melanogaster GN=SdhB PE=2 SV=2 PF13085//PF00111 2Fe-2S iron-sulfur cluster binding domain//2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051536//GO:0009055 iron-sulfur cluster binding//electron carrier activity -- -- KOG3049 Succinate dehydrogenase, Fe-S protein subunit Cluster-10287.0 BF_2 4.00 0.37 739 634887012 XP_007952933.1 777 3.8e-80 PREDICTED: serine/threonine-protein kinase pim-3 [Orycteropus afer afer] 602650072 XM_007431372.1 56 2.39501e-18 PREDICTED: Python bivittatus serine/threonine-protein kinase pim-1-like (LOC103058062), transcript variant X1, mRNA K04702 PIM1 proto-oncogene serine/threonine-protein kinase Pim-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04702 Q95LJ0 768 1.7e-80 Serine/threonine-protein kinase pim-1 OS=Felis catus GN=PIM1 PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-10293.1 BF_2 2.00 0.58 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10294.0 BF_2 8.00 1.01 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10307.0 BF_2 3.00 0.91 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10312.0 BF_2 7.00 0.31 1240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10317.0 BF_2 10.00 1.13 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10320.0 BF_2 8.00 0.60 841 270014925 EFA11373.1 915 4.3e-96 hypothetical protein TcasGA2_TC011532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10322.0 BF_2 2.00 0.41 490 325302648 DAA34573.1 513 1.0e-49 TPA_exp: profilin-like protein [Amblyomma variegatum] -- -- -- -- -- K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 Q9XF39 196 2.4e-14 Profilin OS=Prunus avium PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10331.0 BF_2 4.00 0.37 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10335.1 BF_2 4.00 0.52 609 560971194 XP_006207950.1 460 1.8e-43 PREDICTED: DIS3-like exonuclease 2 [Vicugna pacos] -- -- -- -- -- K18758 DIS3L2 DIS3-like exonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18758 Q8IYB7 447 2.4e-43 DIS3-like exonuclease 2 OS=Homo sapiens GN=DIS3L2 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-10335.2 BF_2 9.00 0.54 984 831299819 XP_012681837.1 496 2.0e-47 PREDICTED: DIS3-like exonuclease 2 [Clupea harengus] -- -- -- -- -- K18758 DIS3L2 DIS3-like exonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18758 Q8IYB7 477 1.3e-46 DIS3-like exonuclease 2 OS=Homo sapiens GN=DIS3L2 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-10336.0 BF_2 12.00 0.32 1856 437279 AAB86499.1 1220 4.1e-131 stearoyl-CoA desaturase [Amblyomma americanum] 437278 U03281.1 69 3.66971e-25 AAU03281 Amblyomma americanum stearoyl-CoA desaturase mRNA, complete cds K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q2KIA4 1009 5.0e-108 Stearoyl-CoA desaturase 5 OS=Bos taurus GN=SCD5 PE=2 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-10337.0 BF_2 4.00 0.45 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10338.0 BF_2 11.00 1.93 525 558200952 XP_006131500.1 140 2.0e-06 PREDICTED: cytochrome c oxidase subunit 7A2, mitochondrial-like [Pelodiscus sinensis] 262401022 FJ774692.1 502 0 Scylla paramamosain cytochrome c oxidase subunit VIIA putative mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10340.1 BF_2 6.00 0.52 772 646711216 KDR16467.1 479 1.4e-45 Nuclear factor interleukin-3-regulated protein [Zootermopsis nevadensis] 692912720 KM413537.1 81 3.17506e-32 Andrena (Melandrena) sp. BF-2014 isolate 1542and ultra conserved element locus uce-1245 genomic sequence K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 Q6IMZ0 241 2.3e-19 Nuclear factor interleukin-3-regulated protein OS=Rattus norvegicus GN=Nfil3 PE=2 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-10340.3 BF_2 5.00 0.35 879 641673178 XP_008186225.1 178 1.3e-10 PREDICTED: LOW QUALITY PROTEIN: G-box-binding factor [Acyrthosiphon pisum] -- -- -- -- -- K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 -- -- -- -- PF09726//PF00170 Transmembrane protein//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-10355.0 BF_2 19.93 2.74 591 478254919 ENN75153.1 348 1.7e-30 hypothetical protein YQE_08266, partial [Dendroctonus ponderosae]>gi|546670711|gb|ERL83361.1| hypothetical protein D910_00280 [Dendroctonus ponderosae]>gi|546670742|gb|ERL83375.1| hypothetical protein D910_00315 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06079 Apyrase -- -- GO:0005509//GO:0016462 calcium ion binding//pyrophosphatase activity -- -- -- -- Cluster-10359.0 BF_2 22.46 1.03 1199 642935674 XP_974741.2 529 3.5e-51 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 419 8.3e-40 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06320 GCN5-like protein 1 (GCN5L1) -- -- -- -- GO:0031083 BLOC-1 complex KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-10361.0 BF_2 1.00 0.35 404 546672269 ERL84205.1 476 1.7e-45 hypothetical protein D910_01583, partial [Dendroctonus ponderosae]>gi|546675576|gb|ERL86742.1| hypothetical protein D910_04148, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5U2Y9 176 4.2e-12 Lebercilin OS=Rattus norvegicus GN=Lca5 PE=2 SV=1 PF04977//PF10473 Septum formation initiator//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0007049 cell cycle GO:0008134//GO:0045502//GO:0042803 transcription factor binding//dynein binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-10364.0 BF_2 6.00 0.46 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10379.0 BF_2 4.00 0.38 732 241151593 XP_002406715.1 214 7.3e-15 calcineurin B, putative [Ixodes scapularis]>gi|215493899|gb|EEC03540.1| calcineurin B, putative [Ixodes scapularis] -- -- -- -- -- K17610 CHP, CHP1 calcineurin B homologous protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17610 Q99653 162 3.2e-10 Calcineurin B homologous protein 1 OS=Homo sapiens GN=CHP1 PE=1 SV=3 PF13202//PF13499//PF13405//PF00036//PF13833 EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair GO:0055114 oxidation-reduction process GO:0016174//GO:0005509 NAD(P)H oxidase activity//calcium ion binding -- -- KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-10381.1 BF_2 3.00 0.49 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10385.0 BF_2 2.00 0.96 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10390.0 BF_2 2.00 0.69 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10401.0 BF_2 2.00 1.31 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10407.0 BF_2 4.00 0.41 698 675386701 KFM79598.1 609 1.1e-60 60S ribosomal protein L7, partial [Stegodyphus mimosarum] 198473483 XM_001356263.2 64 8.05585e-23 Drosophila pseudoobscura pseudoobscura GA18510 (Dpse\GA18510), partial mRNA K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 Q5ZJ56 532 3.8e-53 60S ribosomal protein L7 OS=Gallus gallus GN=RPL7 PE=2 SV=1 PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- KOG3184 60S ribosomal protein L7 Cluster-10408.0 BF_2 4.00 0.32 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10414.0 BF_2 4.00 0.53 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10421.0 BF_2 2.00 1.26 349 313238136 CBY13234.1 225 1.8e-16 unnamed protein product [Oikopleura dioica] 409969319 JQ700925.1 284 1.93393e-145 Uncultured Erythrobacteraceae bacterium clone UV-3_19 16S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10425.0 BF_2 2.00 0.32 551 13628721 O76484.1 790 8.8e-82 RecName: Full=Casein kinase II subunit alpha; Short=CK II subunit alpha [Spodoptera frugiperda]>gi|3249055|gb|AAC24041.1| casein kinase II alpha subunit [Spodoptera frugiperda] 50344983 NM_001002164.1 175 1.23844e-84 Danio rerio zgc:86598 (zgc:86598), mRNA >gnl|BL_ORD_ID|611559 Danio rerio zgc:86598, mRNA (cDNA clone MGC:86598 IMAGE:6891713), complete cds K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 790 3.6e-83 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF00069//PF01335 Protein kinase domain//Death effector domain GO:0006468//GO:0042981 protein phosphorylation//regulation of apoptotic process GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG0668 Casein kinase II, alpha subunit Cluster-10430.0 BF_2 22.00 1.33 979 544512774 XP_005589973.1 992 5.9e-105 PREDICTED: 60S ribosomal protein L13a isoform X1 [Macaca fascicularis]>gi|635040461|ref|XP_007995756.1| PREDICTED: 60S ribosomal protein L13a isoform X1 [Chlorocebus sabaeus] 395132448 NM_012423.3 979 0 Homo sapiens ribosomal protein L13a (RPL13A), transcript variant 1, mRNA K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 P40429 974 3.0e-104 60S ribosomal protein L13a OS=Homo sapiens GN=RPL13A PE=1 SV=2 PF00572 Ribosomal protein L13 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-10434.0 BF_2 2.00 0.58 430 641656935 XP_008180154.1 277 2.1e-22 PREDICTED: uncharacterized protein LOC103308498 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10437.0 BF_2 3.00 0.36 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10438.0 BF_2 4.00 0.31 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10439.1 BF_2 14.30 0.58 1326 642933705 XP_974874.3 967 6.4e-102 PREDICTED: protein OSCP1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHW2 295 2.2e-25 Protein OSCP1 OS=Mus musculus GN=Oscp1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10445.0 BF_2 9.00 0.43 1153 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10462.0 BF_2 13.00 1.50 649 761380060 YP_009121386.1 575 8.9e-57 NADH dehydrogenase subunit 4 (mitochondrion) [Thecamonas trahens]>gi|751130547|gb|AJF36625.1| NADH dehydrogenase subunit 4 (mitochondrion) [Thecamonas trahens] 14254 X57163.1 563 0 T.aestivum nad4 mRNA for NADH-ubiquinone oxidoreductase chain 4 K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P27572 962 4.9e-103 NADH-ubiquinone oxidoreductase chain 4 OS=Triticum aestivum GN=ND4 PE=2 SV=2 PF01059 NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006120//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process -- -- -- -- KOG4845 NADH dehydrogenase, subunit 4 Cluster-10465.0 BF_2 1.00 0.56 358 642925502 XP_008194577.1 217 1.6e-15 PREDICTED: immediate early response 3-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CR20 136 1.6e-07 Immediate early response 3-interacting protein 1 OS=Mus musculus GN=Ier3ip1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10468.0 BF_2 11.00 0.56 1104 826502136 XP_012542232.1 192 3.9e-12 PREDICTED: pro-resilin-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- Q9V7U0 147 2.7e-08 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF06455//PF01299//PF01213//PF00379 NADH dehydrogenase subunit 5 C-terminus//Lysosome-associated membrane glycoprotein (Lamp)//Adenylate cyclase associated (CAP) N terminal//Insect cuticle protein GO:0006744//GO:0006814//GO:0055114//GO:0015992//GO:0006120//GO:0042773//GO:0007010 ubiquinone biosynthetic process//sodium ion transport//oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport//cytoskeleton organization GO:0008137//GO:0042302//GO:0003779 NADH dehydrogenase (ubiquinone) activity//structural constituent of cuticle//actin binding GO:0016020 membrane -- -- Cluster-10470.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10472.0 BF_2 49.74 1.40 1771 478262797 ENN81314.1 424 7.8e-39 hypothetical protein YQE_02282, partial [Dendroctonus ponderosae]>gi|546672918|gb|ERL84634.1| hypothetical protein D910_02062 [Dendroctonus ponderosae] -- -- -- -- -- K04150 HRH2 histamine receptor H2 http://www.genome.jp/dbget-bin/www_bget?ko:K04150 P53452 164 4.5e-10 D(1)-like dopamine receptor OS=Takifugu rubripes GN=d14 PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-10474.1 BF_2 2.00 0.90 378 642913543 XP_971895.2 141 1.1e-06 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10475.0 BF_2 7.00 0.53 835 378556263 AFC17961.1 715 6.7e-73 O-methyltransferase [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- Q86IC8 394 4.6e-37 Probable caffeoyl-CoA O-methyltransferase 2 OS=Dictyostelium discoideum GN=omt6 PE=1 SV=1 PF01596//PF01209 O-methyltransferase//ubiE/COQ5 methyltransferase family -- -- GO:0008168//GO:0008171 methyltransferase activity//O-methyltransferase activity -- -- KOG1663 O-methyltransferase Cluster-10482.0 BF_2 3.00 0.74 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10484.0 BF_2 2.00 1.15 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10490.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10491.0 BF_2 2.00 5.77 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10492.1 BF_2 7.00 0.74 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10493.0 BF_2 5.00 0.57 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10496.0 BF_2 4.00 0.46 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10497.0 BF_2 12.00 0.31 1933 157954037 NP_001103251.1 1992 1.3e-220 ligand-gated chloride channel homolog 3 [Tribolium castaneum]>gi|156447611|gb|ABU63598.1| GABA-gated ion channel [Tribolium castaneum]>gi|270006356|gb|EFA02804.1| ligand-gated chloride channel homolog 3 [Tribolium castaneum] 662198442 XM_008474121.1 282 1.50166e-143 PREDICTED: Diaphorina citri gamma-aminobutyric acid receptor subunit beta-like (LOC103509497), mRNA K05181 GABRB gamma-aminobutyric acid receptor subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K05181 Q08832 1670 1.2e-184 Gamma-aminobutyric acid receptor subunit beta-like OS=Drosophila melanogaster GN=Lcch3 PE=1 SV=2 PF02931//PF02160//PF04277//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Cauliflower mosaic virus peptidase (A3)//Oxaloacetate decarboxylase, gamma chain//Neurotransmitter-gated ion-channel transmembrane region GO:0006560//GO:0007214//GO:0006821//GO:0006811//GO:0006508//GO:0006810//GO:0006525//GO:0071436//GO:0006090//GO:0006814 proline metabolic process//gamma-aminobutyric acid signaling pathway//chloride transport//ion transport//proteolysis//transport//arginine metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport GO:0004190//GO:0004890//GO:0015081//GO:0005230//GO:0008948 aspartic-type endopeptidase activity//GABA-A receptor activity//sodium ion transmembrane transporter activity//extracellular ligand-gated ion channel activity//oxaloacetate decarboxylase activity GO:0005886//GO:0016020//GO:0030054//GO:0016021//GO:0045211 plasma membrane//membrane//cell junction//integral component of membrane//postsynaptic membrane KOG3643 GABA receptor Cluster-10503.0 BF_2 5.00 0.66 604 121543837 ABM55583.1 676 1.6e-68 putative 60S ribosomal protein L23 [Maconellicoccus hirsutus] 801399158 XM_012204683.1 102 5.19678e-44 PREDICTED: Atta cephalotes 60S ribosomal protein L23 (LOC105623284), mRNA K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P48159 668 5.6e-69 60S ribosomal protein L23 OS=Drosophila melanogaster GN=RpL23 PE=1 SV=2 PF00238 Ribosomal protein L14p/L23e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-10519.0 BF_2 5.00 0.36 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10524.0 BF_2 23.00 1.31 1023 270011884 EFA08332.1 198 7.3e-13 hypothetical protein TcasGA2_TC005974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-10541.0 BF_2 2.00 0.90 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10544.0 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10562.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10566.0 BF_2 3.00 0.40 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10568.0 BF_2 6.00 0.42 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10570.0 BF_2 16.00 0.42 1892 728418532 AIY68372.1 1095 1.3e-116 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 668 1.8e-68 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-10571.0 BF_2 3.00 0.55 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10576.0 BF_2 2.00 0.54 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10577.0 BF_2 6.00 0.94 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10581.0 BF_2 6.00 0.66 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10595.0 BF_2 2.00 0.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10615.0 BF_2 5.00 1.03 490 256539088 ACU82846.1 392 1.1e-35 acyl-CoA-binding protein [Fenneropenaeus chinensis] 198473999 XM_001356482.2 34 2.63575e-06 Drosophila pseudoobscura pseudoobscura GA21120 (Dpse\GA21120), partial mRNA K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 P45883 323 4.6e-29 Acyl-CoA-binding protein homolog OS=Pelophylax ridibundus PE=1 SV=2 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-10629.0 BF_2 15.00 5.11 409 268306418 ACY95330.1 484 2.0e-46 ribosomal protein L31 [Manduca sexta] 317143691 XM_003189479.1 54 1.65286e-17 Aspergillus oryzae RIB40 60S ribosomal protein L31, partial mRNA K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 Q9GP16 481 1.8e-47 60S ribosomal protein L31 OS=Heliothis virescens GN=RpL31 PE=2 SV=1 PF01198//PF09618 Ribosomal protein L31e//CRISPR-associated protein (Cas_Csy4) GO:0042254//GO:0006412//GO:0043571 ribosome biogenesis//translation//maintenance of CRISPR repeat elements GO:0004519//GO:0003735 endonuclease activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0893 60S ribosomal protein L31 Cluster-10632.0 BF_2 15.00 0.56 1403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10637.0 BF_2 9.00 0.96 680 302136424 ADK94169.1 797 1.7e-82 nucleoside diphosphate kinase [Eriocheir sinensis] 262401098 FJ774730.1 563 0 Scylla paramamosain oncoprotein nm23 mRNA, partial cds K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P19804 619 3.0e-63 Nucleoside diphosphate kinase B OS=Rattus norvegicus GN=Nme2 PE=1 SV=1 PF04505//PF00334 Interferon-induced transmembrane protein//Nucleoside diphosphate kinase GO:0006144//GO:0006183//GO:0006228//GO:0009607//GO:0006165//GO:0006206//GO:0006241 purine nucleobase metabolic process//GTP biosynthetic process//UTP biosynthetic process//response to biotic stimulus//nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process GO:0004550 nucleoside diphosphate kinase activity GO:0016021 integral component of membrane KOG0888 Nucleoside diphosphate kinase Cluster-10641.0 BF_2 5.00 0.65 610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10645.0 BF_2 3.00 0.32 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10646.0 BF_2 2.00 0.40 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10650.2 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10652.0 BF_2 3.00 0.61 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10663.0 BF_2 6.00 0.34 1029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10675.0 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-10680.0 BF_2 2.00 0.36 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10687.0 BF_2 3.00 0.35 650 646718582 KDR20994.1 952 1.7e-100 Receptor-type tyrosine-protein phosphatase N2 [Zootermopsis nevadensis] 688708454 LL319196.1 34 3.55167e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0000018 K07817 PTPRN receptor-type tyrosine-protein phosphatase N http://www.genome.jp/dbget-bin/www_bget?ko:K07817 O02695 866 6.6e-92 Receptor-type tyrosine-protein phosphatase N2 OS=Macaca nemestrina GN=PTPRN2 PE=2 SV=1 PF00782//PF04565//PF00102//PF01805 Dual specificity phosphatase, catalytic domain//RNA polymerase Rpb2, domain 3//Protein-tyrosine phosphatase//Surp module GO:0006206//GO:0006396//GO:0006351//GO:0006144//GO:0006570//GO:0006470 pyrimidine nucleobase metabolic process//RNA processing//transcription, DNA-templated//purine nucleobase metabolic process//tyrosine metabolic process//protein dephosphorylation GO:0003723//GO:0003899//GO:0003677//GO:0004725//GO:0008138 RNA binding//DNA-directed RNA polymerase activity//DNA binding//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005730 nucleolus KOG0793 Protein tyrosine phosphatase Cluster-10689.0 BF_2 1.00 0.87 327 679189520 KFW80135.1 549 4.6e-54 Tubulin alpha-5 chain, partial [Manacus vitellinus] 385717687 JN944368.1 228 2.42845e-114 Oryza sativa Japonica Group clone KCS185G04 alpha-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P68367 548 2.5e-55 Tubulin alpha-4A chain OS=Macaca fascicularis GN=TUBA4A PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10697.0 BF_2 3.00 0.96 417 -- -- -- -- -- 761231856 KM881642.1 417 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C506 391 5.1e-37 DNA-directed RNA polymerase subunit beta' OS=Oryza sativa subsp. japonica GN=rpoC1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10702.0 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10707.0 BF_2 10.89 0.66 974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10711.0 BF_2 6.00 0.35 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10713.0 BF_2 2.00 0.37 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10722.1 BF_2 6.00 0.73 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10726.0 BF_2 2.00 0.69 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10727.0 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10744.0 BF_2 1.00 0.54 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10749.0 BF_2 3.00 0.80 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10751.0 BF_2 5.00 0.53 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10755.0 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10760.0 BF_2 21.00 0.31 3161 -- -- -- -- -- 462430528 APGK01014989.1 80 4.83248e-31 Dendroctonus ponderosae Seq01014997, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10765.0 BF_2 2.00 0.73 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10766.0 BF_2 1.00 0.36 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus -- -- Cluster-10768.0 BF_2 2.00 0.59 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10769.0 BF_2 6.00 1.05 525 270017038 EFA13484.1 450 2.2e-42 hypothetical protein TcasGA2_TC004223 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 166 7.9e-11 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10772.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10773.0 BF_2 6.00 0.42 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05132//PF04931//PF04147//PF01080//PF14721//PF04546//PF04194//PF03896//PF02535//PF04006//PF03985//PF02724 RNA polymerase III RPC4//DNA polymerase phi//Nop14-like family//Presenilin//Apoptosis-inducing factor, mitochondrion-associated, C-term//Sigma-70, non-essential region//Programmed cell death protein 2, C-terminal putative domain//Translocon-associated protein (TRAP), alpha subunit//ZIP Zinc transporter//Mpp10 protein//Paf1//CDC45-like protein GO:0055085//GO:0006270//GO:0016570//GO:0006260//GO:0006383//GO:0006364//GO:0006355//GO:0030001//GO:0006351//GO:0006368//GO:0006144//GO:0006206//GO:0006352 transmembrane transport//DNA replication initiation//histone modification//DNA replication//transcription from RNA polymerase III promoter//rRNA processing//regulation of transcription, DNA-templated//metal ion transport//transcription, DNA-templated//transcription elongation from RNA polymerase II promoter//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation GO:0003700//GO:0004190//GO:0003887//GO:0046983//GO:0016987//GO:0046873//GO:0003899//GO:0003677 transcription factor activity, sequence-specific DNA binding//aspartic-type endopeptidase activity//DNA-directed DNA polymerase activity//protein dimerization activity//sigma factor activity//metal ion transmembrane transporter activity//DNA-directed RNA polymerase activity//DNA binding GO:0005666//GO:0005730//GO:0005667//GO:0005732//GO:0034457//GO:0016593//GO:0016021//GO:0042575//GO:0005737//GO:0032040//GO:0005789//GO:0005634//GO:0016020 DNA-directed RNA polymerase III complex//nucleolus//transcription factor complex//small nucleolar ribonucleoprotein complex//Mpp10 complex//Cdc73/Paf1 complex//integral component of membrane//DNA polymerase complex//cytoplasm//small-subunit processome//endoplasmic reticulum membrane//nucleus//membrane -- -- Cluster-10774.0 BF_2 3.00 0.35 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10780.0 BF_2 1.00 0.45 379 657568548 XP_008287713.1 147 2.2e-07 PREDICTED: putative defense protein Hdd11 [Stegastes partitus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10787.0 BF_2 6.00 0.40 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10790.0 BF_2 4.00 3.36 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10793.0 BF_2 11.00 0.50 1214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10800.0 BF_2 3.00 0.77 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10804.0 BF_2 4.00 1.43 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10807.0 BF_2 3.00 0.44 570 564275849 ETB57308.1 162 6.0e-09 hypothetical protein YYC_04816 [Plasmodium yoelii 17X] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04086//PF05843//PF07382//PF09726 Signal recognition particle, alpha subunit, N-terminal//Suppressor of forked protein (Suf)//Histone H1-like nucleoprotein HC2//Transmembrane protein GO:0030261//GO:0006886//GO:0006397 chromosome condensation//intracellular protein transport//mRNA processing GO:0005525//GO:0005047//GO:0003924//GO:0003677 GTP binding//signal recognition particle binding//GTPase activity//DNA binding GO:0005785//GO:0005634//GO:0016021//GO:0005786 signal recognition particle receptor complex//nucleus//integral component of membrane//signal recognition particle, endoplasmic reticulum targeting -- -- Cluster-10812.0 BF_2 15.00 0.67 1220 602689962 XP_007457193.1 274 1.3e-21 PREDICTED: 30S ribosomal protein S3, chloroplastic-like [Lipotes vexillifer] 761231856 KM881642.1 1220 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- Q6END5 567 5.8e-57 30S ribosomal protein S3, chloroplastic OS=Oryza nivara GN=rps3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10813.0 BF_2 2.00 0.45 472 34733341 AAQ81630.1 402 7.4e-37 HNF6 beta [Strongylocentrotus purpuratus] 241022758 XM_002405964.1 113 3.07322e-50 Ixodes scapularis ONECUT DNA binding protein, putative, mRNA K08026 ONECUT1, HNF6 one cut domain, family member 1, hepatocyte nuclear factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08026 Q19720 285 1.1e-24 Homeobox protein ceh-38 OS=Caenorhabditis elegans GN=ceh-38 PE=2 SV=2 PF02376 CUT domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-10815.2 BF_2 14.00 0.32 2110 642927152 XP_008195159.1 574 3.8e-56 PREDICTED: uncharacterized protein LOC103313501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10817.0 BF_2 6.00 0.44 860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10818.0 BF_2 3.00 0.33 667 328899359 AEB54635.1 933 2.8e-98 eukaryotic translation initiation factor 3 subunit 12 [Procambarus clarkii] -- -- -- -- -- K15028 EIF3K translation initiation factor 3 subunit K http://www.genome.jp/dbget-bin/www_bget?ko:K15028 Q6GNI4 721 4.4e-75 Eukaryotic translation initiation factor 3 subunit K OS=Xenopus laevis GN=eif3k PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3252 Uncharacterized conserved protein Cluster-10822.0 BF_2 4.00 0.51 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10823.0 BF_2 8.00 9.54 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10824.0 BF_2 3.00 0.68 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10826.0 BF_2 2.00 0.62 421 262401159 ACY66482.1 413 3.5e-38 NADH:ubiquinone dehydrogenase [Scylla paramamosain] 262401158 FJ774761.1 306 1.39911e-157 Scylla paramamosain NADH:ubiquinone dehydrogenase mRNA, partial cds K03960 NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03960 -- -- -- -- PF07225 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0015992//GO:0006814//GO:0006744//GO:0006120 proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion -- -- Cluster-10827.0 BF_2 3.00 0.51 531 198462178 XP_001352360.2 288 1.4e-23 GA16601 [Drosophila pseudoobscura pseudoobscura]>gi|198140184|gb|EAL29314.2| GA16601 [Drosophila pseudoobscura pseudoobscura] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04889//PF00879 Cwf15/Cwc15 cell cycle control protein//Defensin propeptide GO:0006952//GO:0000398 defense response//mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex -- -- Cluster-10836.0 BF_2 1.00 1.82 289 -- -- -- -- -- 768311759 CP010987.1 212 1.65796e-105 Verticillium dahliae VdLs.17 chromosome 8, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10845.0 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10850.0 BF_2 9.00 0.72 811 755785705 XP_003995546.2 1077 6.9e-115 PREDICTED: 40S ribosomal protein S6 [Felis catus] 158256465 AK291517.1 811 0 Homo sapiens cDNA FLJ78049 complete cds, highly similar to Homo sapiens ribosomal protein S6 (RPS6), mRNA K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 P62755 1069 2.4e-115 40S ribosomal protein S6 OS=Rattus norvegicus GN=Rps6 PE=1 SV=1 PF02567//PF01092 Phenazine biosynthesis-like protein//Ribosomal protein S6e GO:0042254//GO:0009058//GO:0006412 ribosome biogenesis//biosynthetic process//translation GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG1646 40S ribosomal protein S6 Cluster-10856.0 BF_2 4.00 0.31 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10865.0 BF_2 3.00 0.51 535 675376796 KFM69698.1 319 3.5e-27 Neuropilin and tolloid-like protein 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10870.0 BF_2 3.00 0.64 482 119619953 EAW99547.1 362 3.3e-32 thymosin, beta 10, isoform CRA_a, partial [Homo sapiens]>gi|119619954|gb|EAW99548.1| thymosin, beta 10, isoform CRA_a, partial [Homo sapiens] 79150724 BC107889.1 463 0 Homo sapiens cDNA clone IMAGE:6651898 K13785 TMSB10 thymosin beta 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13785 P63313 219 5.2e-17 Thymosin beta-10 OS=Homo sapiens GN=TMSB10 PE=1 SV=2 PF02205//PF01290 WH2 motif//Thymosin beta-4 family GO:0007015//GO:0042989 actin filament organization//sequestering of actin monomers GO:0003779//GO:0003785 actin binding//actin monomer binding GO:0005737//GO:0005856 cytoplasm//cytoskeleton -- -- Cluster-10871.0 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10872.0 BF_2 4.00 0.59 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10875.0 BF_2 5.00 0.91 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10886.0 BF_2 2.00 0.71 404 675384914 KFM77811.1 284 3.1e-23 Tropomodulin, partial [Stegodyphus mimosarum] -- -- -- -- -- K10370 TMOD tropomodulin http://www.genome.jp/dbget-bin/www_bget?ko:K10370 P70567 228 3.9e-18 Tropomodulin-1 OS=Rattus norvegicus GN=Tmod1 PE=2 SV=1 PF03250 Tropomodulin GO:0051694 pointed-end actin filament capping GO:0005523 tropomyosin binding -- -- KOG3735 Tropomodulin and leiomodulin Cluster-10893.0 BF_2 17.00 0.42 1984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10897.0 BF_2 5.00 3.56 340 238683727 ACR54142.1 417 9.7e-39 ribosomal protein rps21 [Palaemon varians] 262401362 FJ774863.1 199 3.35067e-98 Scylla paramamosain ribosomal protein S21 mRNA, partial cds K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q6DDC6 342 2.0e-31 40S ribosomal protein S21 OS=Xenopus tropicalis GN=rps21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-10898.0 BF_2 3.00 6.17 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10905.0 BF_2 17.00 1.36 810 391345012 XP_003746787.1 508 6.5e-49 PREDICTED: glutathione S-transferase 1, isoform C-like [Metaseiulus occidentalis] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 396 2.6e-37 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF13409//PF13417//PF00462//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0015035//GO:0009055 protein binding//protein disulfide oxidoreductase activity//electron carrier activity -- -- -- -- Cluster-10923.0 BF_2 11.16 0.78 885 642927632 XP_008195342.1 514 1.4e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 7.0e-28 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF00782//PF00102//PF05706 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004721//GO:0008138//GO:0004725 phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-10936.0 BF_2 6.00 0.33 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10944.0 BF_2 2.00 0.31 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10944.1 BF_2 3.00 0.32 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10947.0 BF_2 93.00 1.24 3431 649572247 NP_001280528.1 1334 4.6e-144 probable G-protein coupled receptor 52 [Tribolium castaneum]>gi|91088793|ref|XP_968380.1| PREDICTED: probable G-protein coupled receptor 52 [Tribolium castaneum]>gi|270012800|gb|EFA09248.1| hypothetical protein TcasGA2_TC006457 [Tribolium castaneum]>gi|485836770|tpg|DAA64512.1| TPA_inf: putative ecdysteroids/dopamine receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C5J4 287 4.8e-24 Probable G-protein coupled receptor 52 OS=Mus musculus GN=Gpr52 PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-10948.0 BF_2 2.62 4.08 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10959.0 BF_2 3.00 0.50 539 242003954 XP_002436238.1 370 4.4e-33 secreted salivary gland peptide, putative [Ixodes scapularis]>gi|55736021|gb|AAV63537.1| fed tick salivary protein 3 [Ixodes scapularis]>gi|215499574|gb|EEC09068.1| secreted salivary gland peptide, putative [Ixodes scapularis] -- -- -- -- -- K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q6XHI1 295 8.9e-26 Thioredoxin-2 OS=Drosophila yakuba GN=Trx-2 PE=3 SV=1 PF00462//PF00578//PF00085//PF08534 Glutaredoxin//AhpC/TSA family//Thioredoxin//Redoxin GO:0006662//GO:0006118//GO:0055114//GO:0045454 glycerol ether metabolic process//obsolete electron transport//oxidation-reduction process//cell redox homeostasis GO:0016491//GO:0016853//GO:0016209//GO:0015035//GO:0009055 oxidoreductase activity//isomerase activity//antioxidant activity//protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG0907 Thioredoxin Cluster-10961.0 BF_2 3.00 0.50 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10962.0 BF_2 5.00 0.33 929 395133291 AFN44699.1 497 1.4e-47 cystatin A precursor [Portunus trituberculatus] 395133290 JQ950686.1 328 1.90097e-169 Portunus trituberculatus cystatin A precursor, gene, complete cds K13907 CSTA_B cystatin-A/B http://www.genome.jp/dbget-bin/www_bget?ko:K13907 P01040 205 4.2e-15 Cystatin-A OS=Homo sapiens GN=CSTA PE=1 SV=1 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-10981.0 BF_2 4.00 0.84 486 241555482 XP_002399793.1 278 1.8e-22 5' nucleotidase, putative [Ixodes scapularis]>gi|215501733|gb|EEC11227.1| 5' nucleotidase, putative [Ixodes scapularis] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 P52307 246 3.9e-20 Protein 5NUC (Fragment) OS=Rhipicephalus microplus PE=1 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-10984.0 BF_2 3.00 1.52 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10989.0 BF_2 2.00 0.36 518 558142705 XP_006092712.1 330 1.8e-28 PREDICTED: cytochrome P450 4V2-like [Myotis lucifugus] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 304 7.7e-27 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-10997.0 BF_2 5.00 1.51 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10997.1 BF_2 5.00 0.46 742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-10998.0 BF_2 11.40 0.39 1499 546686115 ERL95507.1 275 1.3e-21 hypothetical protein D910_12769 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0Y6 148 2.8e-08 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-10999.0 BF_2 24.30 1.21 1125 300394168 ADK11710.1 583 1.8e-57 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P91885 337 2.5e-30 Aminopeptidase N OS=Manduca sexta GN=APN2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-11009.0 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11010.0 BF_2 3.00 1.96 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11015.0 BF_2 3.00 0.61 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11026.1 BF_2 62.00 2.27 1432 642917777 XP_008191282.1 906 8.2e-95 PREDICTED: ADP-ribosylation factor-like protein 13B [Tribolium castaneum] -- -- -- -- -- K07962 ARL13B, ARL2L1 ADP-ribosylation factor-like protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K07962 Q3SXY8 427 1.2e-40 ADP-ribosylation factor-like protein 13B OS=Homo sapiens GN=ARL13B PE=1 SV=1 PF08477//PF01926//PF00503//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//Ras family//ADP-ribosylation factor family GO:0007264//GO:0007186//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0003924//GO:0031683 GTP binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//G-protein beta/gamma-subunit complex binding -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-11027.0 BF_2 6.00 0.36 991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11028.0 BF_2 3.00 0.65 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17123 RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-11046.0 BF_2 6.00 0.36 989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11047.0 BF_2 4.00 2.45 351 241159531 XP_002408582.1 294 1.8e-24 alternative splicing factor ASF/SF2, putative [Ixodes scapularis]>gi|215494365|gb|EEC04006.1| alternative splicing factor ASF/SF2, putative [Ixodes scapularis] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 270 4.6e-23 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-11052.1 BF_2 2.00 0.42 487 675375082 KFM67984.1 357 1.3e-31 Lysosome membrane protein 2, partial [Stegodyphus mimosarum] -- -- -- -- -- K06259 CD36 CD36 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06259 P16671 243 8.6e-20 Platelet glycoprotein 4 OS=Homo sapiens GN=CD36 PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane KOG3776 Plasma membrane glycoprotein CD36 and related membrane receptors Cluster-11057.0 BF_2 3.00 0.31 687 675365961 KFM58863.1 306 1.5e-25 Protein Tob2, partial [Stegodyphus mimosarum] 807031772 XM_004527399.2 46 8.03529e-13 PREDICTED: Ceratitis capitata protein Tob1 (LOC101449994), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P50616 138 1.8e-07 Protein Tob1 OS=Homo sapiens GN=TOB1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11065.0 BF_2 2.00 1.19 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11068.1 BF_2 2.00 1.73 327 -- -- -- -- -- 392303569 JX102602.1 283 6.47139e-145 Scylla paramamosain microsatellite Spm31 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11074.0 BF_2 5.00 0.31 954 662188029 XP_008487669.1 190 5.7e-12 PREDICTED: uncharacterized protein LOC103524433 [Diaphorina citri]>gi|662188031|ref|XP_008487670.1| PREDICTED: uncharacterized protein LOC103524433 [Diaphorina citri]>gi|662219621|ref|XP_008483903.1| PREDICTED: uncharacterized protein LOC103520579 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:1903818//GO:0030431//GO:0032222//GO:0007178//GO:0016310//GO:0009069 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic//transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-11084.0 BF_2 1.00 2.11 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11084.1 BF_2 5.00 0.61 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11094.0 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11101.0 BF_2 2.00 0.82 387 873225295 CEM24109.1 142 8.5e-07 unnamed protein product [Vitrella brassicaformis CCMP3155] 645279575 XM_008246566.1 122 2.46071e-55 PREDICTED: Prunus mume macrophage migration inhibitory factor homolog (LOC103342902), transcript variant X2, mRNA -- -- -- -- P81529 137 1.3e-07 Macrophage migration inhibitory factor homolog OS=Trichinella spiralis PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-11104.0 BF_2 11.26 0.33 1724 780678076 XP_011696906.1 990 1.8e-104 PREDICTED: leupaxin isoform X6 [Wasmannia auropunctata] 766928065 XM_011497756.1 192 1.43426e-93 PREDICTED: Ceratosolen solmsi marchali paxillin (LOC105360757), partial mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49023 800 7.9e-84 Paxillin OS=Homo sapiens GN=PXN PE=1 SV=3 PF01258//PF00412//PF01155//PF08047 Prokaryotic dksA/traR C4-type zinc finger//LIM domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Histidine operon leader peptide GO:0006464//GO:0000105 cellular protein modification process//histidine biosynthetic process GO:0008270//GO:0016151 zinc ion binding//nickel cation binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-11109.0 BF_2 8.00 0.63 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11117.0 BF_2 2.00 0.40 494 457866969 CCQ18595.1 194 1.0e-12 40S ribosomal protein S25 [Sycon ciliatum] 697083099 XM_009656438.1 462 0 Verticillium dahliae VdLs.17 40S ribosomal protein S25 mRNA K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q7SC06 303 9.6e-27 40S ribosomal protein S25 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-25 PE=3 SV=1 PF08220//PF01047 DeoR-like helix-turn-helix domain//MarR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG1767 40S ribosomal protein S25 Cluster-11120.0 BF_2 8.00 0.31 1380 646722324 KDR23337.1 538 3.7e-52 Cyclin-G2 [Zootermopsis nevadensis] 768416096 XM_011550323.1 35 2.15546e-06 PREDICTED: Plutella xylostella cyclin-G1 (LOC105380726), transcript variant X4, mRNA K10146 CCNG2 cyclin G2 http://www.genome.jp/dbget-bin/www_bget?ko:K10146 O08918 235 2.1e-18 Cyclin-G2 OS=Mus musculus GN=Ccng2 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0653 Cyclin B and related kinase-activating proteins Cluster-11122.0 BF_2 1.00 1.05 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11143.0 BF_2 2.00 0.60 426 391326800 XP_003737899.1 296 1.3e-24 PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like [Metaseiulus occidentalis] -- -- -- -- -- K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 261 6.2e-22 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-11145.1 BF_2 4.00 0.45 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11147.0 BF_2 3.00 0.74 457 646711477 KDR16622.1 689 3.8e-70 Dihydrolipoyl dehydrogenase, mitochondrial [Zootermopsis nevadensis] 799328813 XM_012194231.1 45 1.8771e-12 Cryptococcus neoformans var. grubii H99 dihydrolipoyl dehydrogenase mRNA K00382 DLD, lpd, pdhD dihydrolipoamide dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00382 Q8CIZ7 665 9.4e-69 Dihydrolipoyl dehydrogenase, mitochondrial OS=Cricetulus griseus GN=DLD PE=2 SV=1 PF01821//PF02852 Anaphylotoxin-like domain//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain GO:0055114//GO:0045454 oxidation-reduction process//cell redox homeostasis -- -- GO:0005576 extracellular region KOG1335 Dihydrolipoamide dehydrogenase Cluster-11155.1 BF_2 1.00 1.13 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-11156.0 BF_2 2.00 0.34 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11158.0 BF_2 4.00 0.33 792 861622273 KMQ87706.1 704 1.2e-71 retrovirus-related gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P04146 419 5.5e-40 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF02234 Cyclin-dependent kinase inhibitor GO:0007050//GO:0045859 cell cycle arrest//regulation of protein kinase activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634 nucleus -- -- Cluster-11185.0 BF_2 2.00 0.85 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11186.1 BF_2 6.00 0.49 798 752867953 XP_011251028.1 1208 4.4e-130 PREDICTED: adenosylhomocysteinase [Camponotus floridanus] 56363948 CR725945.2 180 3.04083e-87 Tetraodon nigroviridis full-length cDNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q27580 1174 1.6e-127 Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=2 SV=2 PF00208//PF05221//PF13241//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//S-adenosyl-L-homocysteine hydrolase//Putative NAD(P)-binding//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006555//GO:0006520//GO:0006779//GO:0055114//GO:0006730//GO:0019354 methionine metabolic process//cellular amino acid metabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//one-carbon metabolic process//siroheme biosynthetic process GO:0016491//GO:0004013//GO:0051287//GO:0043115 oxidoreductase activity//adenosylhomocysteinase activity//NAD binding//precorrin-2 dehydrogenase activity -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-11190.0 BF_2 1.00 0.34 411 646721422 KDR22770.1 283 4.1e-23 UDP-glucuronosyltransferase 2B1, partial [Zootermopsis nevadensis] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P36514 181 1.1e-12 UDP-glucuronosyltransferase 2C1 (Fragment) OS=Oryctolagus cuniculus GN=UGT2C1 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-11193.0 BF_2 8.00 0.63 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11197.0 BF_2 2.00 0.35 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11200.0 BF_2 3.00 1.14 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11201.0 BF_2 24.00 1.94 804 291231084 XP_002735493.1 321 3.1e-27 PREDICTED: chloride intracellular channel protein 5-like [Saccoglossus kowalevskii] 702423143 XM_010068916.1 224 1.06396e-111 PREDICTED: Eucalyptus grandis glutathione S-transferase DHAR2-like (LOC104454151), transcript variant X2, mRNA -- -- -- -- Q9FRL8 851 4.5e-90 Glutathione S-transferase DHAR2 OS=Arabidopsis thaliana GN=DHAR2 PE=1 SV=1 PF13409//PF13417//PF00462//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0015035//GO:0009055 protein binding//protein disulfide oxidoreductase activity//electron carrier activity -- -- -- -- Cluster-11203.0 BF_2 2.00 0.34 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11206.1 BF_2 3.00 0.59 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11210.0 BF_2 5.00 1.42 434 462269717 AGH24378.1 526 2.9e-51 NADH dehydrogenase subunit 4 (mitochondrion) [Reclinomonas americana ATCC 50283] 167375202 EU414245.1 425 0 Bambusa oldhamii NADH dehydrogenase subunit 4 gene, complete cds; mitochondrial K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P27572 596 9.0e-61 NADH-ubiquinone oxidoreductase chain 4 OS=Triticum aestivum GN=ND4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4845 NADH dehydrogenase, subunit 4 Cluster-11212.0 BF_2 3.00 0.47 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11215.0 BF_2 3.00 0.50 537 762084667 XP_011424831.1 259 3.2e-20 PREDICTED: histone H1-delta-like [Crassostrea gigas]>gi|762163539|ref|XP_011420060.1| PREDICTED: histone H1-delta-like [Crassostrea gigas]>gi|405971941|gb|EKC36743.1| Histone H5 [Crassostrea gigas]>gi|405977348|gb|EKC41805.1| Histone H5 [Crassostrea gigas] 262401068 FJ774715.1 204 9.11885e-101 Scylla paramamosain histone H1-like protein mRNA, partial cds K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P06144 222 2.6e-17 Late histone H1 OS=Lytechinus pictus PE=3 SV=1 PF07382//PF00538//PF01873 Histone H1-like nucleoprotein HC2//linker histone H1 and H5 family//Domain found in IF2B/IF5 GO:0006334//GO:0006446//GO:0006413//GO:0030261 nucleosome assembly//regulation of translational initiation//translational initiation//chromosome condensation GO:0003677//GO:0003743 DNA binding//translation initiation factor activity GO:0000786//GO:0005634//GO:0005840 nucleosome//nucleus//ribosome -- -- Cluster-11217.0 BF_2 2.00 2.17 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-11225.0 BF_2 12.00 0.83 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11226.0 BF_2 7.00 1.46 487 67084027 AAY66948.1 498 5.6e-48 ribosomal protein L35a [Ixodes scapularis] -- -- -- -- -- K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P61272 391 5.9e-37 60S ribosomal protein L35a OS=Macaca fascicularis GN=RPL35A PE=3 SV=1 PF01247 Ribosomal protein L35Ae GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-11232.0 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11236.0 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11236.1 BF_2 10.00 0.73 862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11246.0 BF_2 2.00 0.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11250.1 BF_2 3.00 0.38 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11253.0 BF_2 3.00 0.45 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11254.0 BF_2 8.00 0.91 656 270012947 EFA09395.1 521 1.6e-50 hypothetical protein TcasGA2_TC004313 [Tribolium castaneum] -- -- -- -- -- K04911 KCNH8 potassium voltage-gated channel Eag-related subfamily H member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K04911 Q9WVJ0 415 1.3e-39 Potassium voltage-gated channel subfamily H member 3 OS=Mus musculus GN=Kcnh3 PE=2 SV=2 PF08447 PAS fold -- -- GO:0005515 protein binding -- -- KOG0501 K+-channel KCNQ Cluster-11255.0 BF_2 5.00 0.43 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11280.0 BF_2 41.82 0.76 2600 478250873 ENN71362.1 1423 1.7e-154 hypothetical protein YQE_11977, partial [Dendroctonus ponderosae]>gi|546685616|gb|ERL95092.1| hypothetical protein D910_12362 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P97500 549 1.5e-54 Myelin transcription factor 1-like protein OS=Mus musculus GN=Myt1l PE=2 SV=2 PF07851//PF04977//PF06156//PF04111//PF05529//PF04871//PF06005//PF01920//PF13851//PF10473//PF05837//PF01105//PF01530 TMPIT-like protein//Septum formation initiator//Protein of unknown function (DUF972)//Autophagy protein Apg6//B-cell receptor-associated protein 31-like//Uso1 / p115 like vesicle tethering protein, C terminal region//Protein of unknown function (DUF904)//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H)//emp24/gp25L/p24 family/GOLD//Zinc finger, C2HC type GO:0048870//GO:0006457//GO:0000917//GO:0043093//GO:0006914//GO:0006886//GO:0006810//GO:0051382//GO:0007049//GO:0015031//GO:0006355//GO:0006260 cell motility//protein folding//barrier septum assembly//FtsZ-dependent cytokinesis//autophagy//intracellular protein transport//transport//kinetochore assembly//cell cycle//protein transport//regulation of transcription, DNA-templated//DNA replication GO:0042803//GO:0008134//GO:0045502//GO:0003700//GO:0051082//GO:0008270//GO:0008565 protein homodimerization activity//transcription factor binding//dynein binding//transcription factor activity, sequence-specific DNA binding//unfolded protein binding//zinc ion binding//protein transporter activity GO:0005667//GO:0005783//GO:0005634//GO:0030286//GO:0000776//GO:0016020//GO:0016021//GO:0031514//GO:0005737//GO:0016272 transcription factor complex//endoplasmic reticulum//nucleus//dynein complex//kinetochore//membrane//integral component of membrane//motile cilium//cytoplasm//prefoldin complex KOG3803 Transcription factor containing C2HC type Zn finger Cluster-11282.0 BF_2 2.00 0.64 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11295.0 BF_2 4.00 0.31 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05373 L-proline 3-hydroxylase, C-terminal GO:0055114 oxidation-reduction process GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-11300.0 BF_2 3.00 0.80 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11300.1 BF_2 2.00 0.86 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11306.0 BF_2 2.00 0.44 475 755959281 XP_011304347.1 384 9.2e-35 PREDICTED: choline-phosphate cytidylyltransferase A-like [Fopius arisanus]>gi|755959285|ref|XP_011304348.1| PREDICTED: choline-phosphate cytidylyltransferase A-like [Fopius arisanus]>gi|755959288|ref|XP_011304350.1| PREDICTED: choline-phosphate cytidylyltransferase A-like [Fopius arisanus]>gi|755959291|ref|XP_011304351.1| PREDICTED: choline-phosphate cytidylyltransferase A-like [Fopius arisanus]>gi|755959295|ref|XP_011304352.1| PREDICTED: choline-phosphate cytidylyltransferase A-like [Fopius arisanus]>gi|755959298|ref|XP_011304353.1| PREDICTED: choline-phosphate cytidylyltransferase A-like [Fopius arisanus] -- -- -- -- -- K00968 PCYT1 choline-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00968 P49586 280 4.3e-24 Choline-phosphate cytidylyltransferase A OS=Mus musculus GN=Pcyt1a PE=1 SV=1 PF10440 Ubiquitin-binding WIYLD domain GO:0006479//GO:0006554 protein methylation//lysine catabolic process GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-11309.0 BF_2 4.00 0.32 815 391342930 XP_003745768.1 192 2.9e-12 PREDICTED: gastric triacylglycerol lipase-like [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00326 Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- -- -- Cluster-11313.0 BF_2 1.00 0.44 380 -- -- -- -- -- 45860987 AC135498.3 365 0 Oryza sativa Japonica Group chromosome 11 clone OSJNBa0010M24, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11316.0 BF_2 2.00 1.21 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11325.0 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11333.0 BF_2 8.00 1.59 497 795176426 XP_011843698.1 347 1.9e-30 PREDICTED: uncharacterized protein LOC105545383 [Mandrillus leucophaeus] 34528198 AK130958.1 497 0 Homo sapiens cDNA FLJ27448 fis, clone DMC07139 K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P05386 318 1.8e-28 60S acidic ribosomal protein P1 OS=Homo sapiens GN=RPLP1 PE=1 SV=1 PF04625 DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213 structural constituent of chorion GO:0005576//GO:0042600 extracellular region//chorion KOG1762 60s acidic ribosomal protein P1 Cluster-11344.0 BF_2 5.94 2.49 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11346.0 BF_2 2.00 0.70 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11349.0 BF_2 12.79 0.94 855 270016431 EFA12877.1 365 2.6e-32 hypothetical protein TcasGA2_TC011555 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF01581//PF00096 C2H2-type zinc finger//FMRFamide related peptide family//Zinc finger, C2H2 type GO:0007218 neuropeptide signaling pathway GO:0046872 metal ion binding -- -- -- -- Cluster-11351.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11358.0 BF_2 7.00 0.58 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01442 Apolipoprotein A1/A4/E domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-11364.0 BF_2 2.00 0.41 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11366.0 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11367.0 BF_2 9.00 1.47 543 67084035 AAY66952.1 702 1.4e-71 40S ribosomal protein S11 [Ixodes scapularis] 831245630 XM_003801485.2 120 4.57544e-54 PREDICTED: Otolemur garnettii ribosomal protein S11 (RPS11), mRNA K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P62281 640 8.9e-66 40S ribosomal protein S11 OS=Mus musculus GN=Rps11 PE=1 SV=3 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1728 40S ribosomal protein S11 Cluster-11378.0 BF_2 2.00 1.46 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11384.0 BF_2 2.00 0.81 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11385.0 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF00537 Arthropod defensin//Scorpion toxin-like domain GO:0006810//GO:0006952 transport//defense response GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-11400.0 BF_2 5.00 0.59 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11407.0 BF_2 10.39 0.31 1678 675383246 KFM76143.1 197 1.6e-12 Protein bunched, class 2/F isoform, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q24523 172 5.1e-11 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 PF01166//PF08395//PF06156//PF11365//PF07716 TSC-22/dip/bun family//7tm Chemosensory receptor//Protein of unknown function (DUF972)//Protein of unknown function (DUF3166)//Basic region leucine zipper GO:0006355//GO:0050909//GO:0006260//GO:0010506 regulation of transcription, DNA-templated//sensory perception of taste//DNA replication//regulation of autophagy GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005615//GO:0016021//GO:0005667 extracellular space//integral component of membrane//transcription factor complex KOG4797 Transcriptional regulator Cluster-11410.1 BF_2 3.00 3.14 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11410.2 BF_2 3.00 0.71 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11416.0 BF_2 102.00 11.73 651 570341954 AHE77375.1 299 9.0e-25 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 232 2.2e-18 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11421.0 BF_2 9.00 2.76 423 264667055 ACY71124.1 335 3.9e-29 60S acidic ribosomal protein P2-like protein [Scylla paramamosain] 264667054 FJ790490.1 376 0 Scylla paramamosain 60S acidic ribosomal protein P2-like protein mRNA, complete cds K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P02399 196 2.1e-14 60S acidic ribosomal protein P2 OS=Artemia salina PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-11424.0 BF_2 4.00 0.43 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11434.0 BF_2 1.00 0.45 379 -- -- -- -- -- 53792645 AP003682.3 290 9.78246e-149 Oryza sativa Japonica Group genomic DNA, chromosome 6, PAC clone:P0427B07 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11436.1 BF_2 1.00 0.69 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11438.0 BF_2 4.00 2.51 349 593762830 XP_007120058.1 574 6.2e-57 PREDICTED: 60S ribosomal protein L10 [Physeter catodon] 746817425 NM_001256577.2 332 4.01225e-172 Homo sapiens ribosomal protein L10 (RPL10), transcript variant 2, mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q6ZWV3 529 4.2e-53 60S ribosomal protein L10 OS=Mus musculus GN=Rpl10 PE=1 SV=3 PF00252 Ribosomal protein L16p/L10e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-11438.1 BF_2 4.00 1.18 428 821015621 XP_012360595.1 698 3.2e-71 PREDICTED: 60S ribosomal protein L10-like isoform X2 [Nomascus leucogenys] 746817431 NM_001303625.1 428 0 Homo sapiens ribosomal protein L10 (RPL10), transcript variant 5, mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q4R7Y2 652 2.8e-67 60S ribosomal protein L10 OS=Macaca fascicularis GN=RPL10 PE=2 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-11442.0 BF_2 17.29 0.44 1932 91079971 XP_969899.1 660 3.7e-66 PREDICTED: beta-1,3-galactosyltransferase 5 [Tribolium castaneum]>gi|270004606|gb|EFA01054.1| hypothetical protein TcasGA2_TC003970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N293 331 2.1e-29 Beta-1,3-galactosyltransferase 5 (Fragment) OS=Gorilla gorilla gorilla GN=B3GALT5 PE=3 SV=2 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-11450.0 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11451.0 BF_2 2.00 0.59 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11460.0 BF_2 8.00 0.82 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11462.0 BF_2 11.00 0.78 875 215274047 ACJ64921.1 1155 6.7e-124 nicotinic acetylcholine receptor alpha 2 [Leptinotarsa decemlineata] 752868800 XM_011253184.1 104 5.92737e-45 PREDICTED: Camponotus floridanus acetylcholine receptor subunit alpha-L1 (LOC105248417), transcript variant X3, mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P17644 877 4.7e-93 Acetylcholine receptor subunit alpha-like 2 OS=Drosophila melanogaster GN=nAChRalpha2 PE=2 SV=1 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-11463.0 BF_2 16.00 1.49 735 91090422 XP_971423.1 529 2.2e-51 PREDICTED: cytochrome P450 4C1 [Tribolium castaneum]>gi|270014309|gb|EFA10757.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 P29981 353 2.3e-32 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF12125//PF00067//PF16517 D domain of beta-TrCP//Cytochrome P450//Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain GO:0055114//GO:0007165 oxidation-reduction process//signal transduction GO:0046983//GO:0020037//GO:0005506//GO:0016705 protein dimerization activity//heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-11470.0 BF_2 4.00 0.50 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11473.0 BF_2 6.00 0.43 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11475.0 BF_2 1.00 0.48 372 321458302 EFX69372.1 163 3.0e-09 endoglucanase-1,4-beta-glucanase [Daphnia pulex] -- -- -- -- -- -- -- -- -- P26222 126 2.4e-06 Endoglucanase E-2 OS=Thermobifida fusca GN=celB PE=1 SV=2 PF00553 Cellulose binding domain GO:0005975 carbohydrate metabolic process GO:0030246//GO:0004553 carbohydrate binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-11479.0 BF_2 1.00 3.05 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11489.0 BF_2 1.00 1.05 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11500.0 BF_2 3.00 0.48 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11503.0 BF_2 18.49 0.99 1065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11523.0 BF_2 1.00 0.93 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11524.0 BF_2 5.00 0.38 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11528.0 BF_2 5.00 0.67 598 665805303 XP_008550839.1 459 2.3e-43 PREDICTED: histone H2B-like [Microplitis demolitor]>gi|665818284|ref|XP_008557962.1| PREDICTED: histone H2B-like [Microplitis demolitor] -- -- -- -- -- K11252 H2B histone H2B http://www.genome.jp/dbget-bin/www_bget?ko:K11252 P59781 443 6.8e-43 Histone H2B OS=Drosophila erecta GN=His2B PE=3 SV=2 PF03847//PF00125 Transcription initiation factor TFIID subunit A//Core histone H2A/H2B/H3/H4 GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding GO:0005669 transcription factor TFIID complex -- -- Cluster-11531.0 BF_2 15.00 0.54 1441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11534.0 BF_2 13.00 3.37 448 836712689 XP_012790459.1 566 6.8e-56 PREDICTED: 60S ribosomal protein L35a [Sorex araneus] 92446709 BC001783.1 448 0 Homo sapiens mRNA similar to ribosomal protein L35a (cDNA clone IMAGE:3355533) K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 Q5R8K6 566 2.8e-57 60S ribosomal protein L35a OS=Pongo abelii GN=RPL35A PE=3 SV=1 PF01782//PF01247 RimM N-terminal domain//Ribosomal protein L35Ae GO:0042254//GO:0006412//GO:0006364 ribosome biogenesis//translation//rRNA processing GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-11538.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11539.0 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11556.0 BF_2 15.00 0.76 1113 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11558.0 BF_2 9.00 0.51 1020 391336140 XP_003742440.1 1077 8.6e-115 PREDICTED: cathepsin L-like [Metaseiulus occidentalis] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 919 7.4e-98 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF02159//PF03051//PF00112 Oestrogen receptor//Peptidase C1-like family//Papain family cysteine protease GO:0006508//GO:0043401//GO:0006355//GO:0007165 proteolysis//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0030284//GO:0008234//GO:0005496//GO:0004197//GO:0003677 estrogen receptor activity//cysteine-type peptidase activity//steroid binding//cysteine-type endopeptidase activity//DNA binding GO:0005634 nucleus KOG1543 Cysteine proteinase Cathepsin L Cluster-11562.0 BF_2 11.00 0.37 1521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11563.0 BF_2 7.00 0.34 1157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11564.0 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00569 Zinc finger, ZZ type -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-11565.0 BF_2 3.00 0.39 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11573.0 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11585.0 BF_2 6.00 0.52 768 391336366 XP_003742552.1 590 1.9e-58 PREDICTED: uncharacterized protein LOC100905186 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11587.0 BF_2 5.00 0.77 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11588.0 BF_2 14.00 1.49 681 256002943 ACU52718.1 889 3.6e-93 ribosomal protein L10a [Fenneropenaeus merguiensis] 256002942 FJ623402.1 309 5.013e-159 Fenneropenaeus merguiensis ribosomal protein L10a mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 780 6.5e-82 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG1570 60S ribosomal protein L10A Cluster-11592.0 BF_2 1.45 0.37 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11599.0 BF_2 27.87 0.47 2762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11602.0 BF_2 2.00 0.40 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11608.0 BF_2 3.29 0.59 520 795179018 XP_011800353.1 588 2.2e-58 PREDICTED: uncharacterized protein LOC105513924 [Colobus angolensis palliatus] 214829180 NM_001026.4 520 0 Homo sapiens ribosomal protein S24 (RPS24), transcript variant c, mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 P62847 584 2.7e-59 40S ribosomal protein S24 OS=Homo sapiens GN=RPS24 PE=1 SV=1 PF01282 Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3424 40S ribosomal protein S24 Cluster-11611.0 BF_2 6.00 0.87 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11612.0 BF_2 5.00 0.44 761 325303222 DAA34697.1 281 1.3e-22 TPA_inf: putative thyropin precursor [Amblyomma variegatum] -- -- -- -- -- -- -- -- -- P84032 175 1.0e-11 U24-ctenitoxin-Pn1a OS=Phoneutria nigriventer PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-11622.0 BF_2 2.00 0.35 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11633.0 BF_2 11.00 1.49 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11635.0 BF_2 1.00 0.39 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11637.0 BF_2 1.00 0.34 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-11641.0 BF_2 3.00 0.45 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11650.0 BF_2 5.00 0.31 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11660.0 BF_2 10.00 0.74 853 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11674.0 BF_2 3.00 0.55 516 328697334 XP_001945830.2 831 1.5e-86 PREDICTED: serine/threonine-protein kinase tricorner isoform X1 [Acyrthosiphon pisum] 817211608 XM_012426526.1 141 9.18177e-66 PREDICTED: Orussus abietinus serine/threonine-protein kinase tricorner (LOC105700568), transcript variant X4, mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q9NBK5 793 1.5e-83 Serine/threonine-protein kinase tricorner OS=Drosophila melanogaster GN=trc PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0605 NDR and related serine/threonine kinases Cluster-11683.0 BF_2 5.00 0.48 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11697.0 BF_2 7.00 7.60 314 675798858 XP_008955633.1 452 7.8e-43 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Pan paniscus] 302489111 NG_027450.1 314 3.61869e-162 Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha pseudogene (LOC100422375) on chromosome 22 K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 P42337 300 1.4e-26 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Mus musculus GN=Pik3ca PE=1 SV=2 PF04901//PF02985 Receptor activity modifying family//HEAT repeat GO:0006886//GO:0015031//GO:0008277 intracellular protein transport//protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-11699.0 BF_2 5.00 0.60 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11701.0 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11711.0 BF_2 17.00 0.44 1894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11714.0 BF_2 2.55 0.33 614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11727.0 BF_2 1.00 0.48 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11728.0 BF_2 3.00 0.65 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11729.0 BF_2 57.45 0.75 3504 642935498 XP_008198034.1 4844 0.0e+00 PREDICTED: rap guanine nucleotide exchange factor 4 isoform X1 [Tribolium castaneum] 676496084 XM_009068851.1 107 5.25027e-46 Lottia gigantea hypothetical protein partial mRNA K04351 RAPGEF4, EPAC2 Rap guanine nucleotide exchange factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04351 Q8WZA2 2594 1.5e-291 Rap guanine nucleotide exchange factor 4 OS=Homo sapiens GN=RAPGEF4 PE=1 SV=1 PF00610//PF00617 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//RasGEF domain GO:0007264//GO:0035556//GO:0043087 small GTPase mediated signal transduction//intracellular signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG2378 cAMP-regulated guanine nucleotide exchange factor Cluster-11733.0 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11735.0 BF_2 2.00 0.32 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11757.0 BF_2 2.00 0.54 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11769.0 BF_2 3.00 0.38 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11771.0 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-11780.0 BF_2 6.00 0.38 949 330841223 XP_003292601.1 771 2.4e-79 hypothetical protein DICPUDRAFT_40821 [Dictyostelium purpureum]>gi|325077131|gb|EGC30864.1| hypothetical protein DICPUDRAFT_40821 [Dictyostelium purpureum] -- -- -- -- -- K01368 CTSS cathepsin S http://www.genome.jp/dbget-bin/www_bget?ko:K01368 Q86GF7 666 1.5e-68 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008233//GO:0004197//GO:0008234 peptidase activity//cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-11781.0 BF_2 3.23 0.33 691 148692627 EDL24574.1 815 1.4e-84 mCG140959, isoform CRA_d, partial [Mus musculus] 675780827 XM_003824937.2 691 0 PREDICTED: Pan paniscus myosin, light chain 6, alkali, smooth muscle and non-muscle (MYL6), transcript variant X2, mRNA K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 Q5R844 791 3.5e-83 Myosin light polypeptide 6 OS=Pongo abelii GN=MYL6 PE=2 SV=3 PF13202//PF13499//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-11803.0 BF_2 7.00 0.45 937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11804.0 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11808.0 BF_2 5.53 3.14 357 91078376 XP_974169.1 252 1.4e-19 PREDICTED: tyramine beta-hydroxylase [Tribolium castaneum]>gi|270003980|gb|EFA00428.1| hypothetical protein TcasGA2_TC003282 [Tribolium castaneum]>gi|390979538|dbj|BAM21526.1| tyramine beta hydroxylase, partial [Tribolium castaneum] -- -- -- -- -- K00503 DBH dopamine beta-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00503 -- -- -- -- -- -- GO:0006584//GO:0006570//GO:0055114 catecholamine metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0005507//GO:0004500 copper ion binding//dopamine beta-monooxygenase activity -- -- -- -- Cluster-11823.0 BF_2 4.00 0.42 690 801385089 XP_012055790.1 371 4.3e-33 PREDICTED: LOW QUALITY PROTEIN: protein H2A.5-like [Atta cephalotes] 688431088 LL189456.1 118 7.62803e-53 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0001086 K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84054 371 1.8e-34 Histone H2A OS=Drosophila simulans GN=His2A PE=3 SV=2 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-11825.0 BF_2 4.00 0.37 742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11856.0 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11859.0 BF_2 3.14 0.32 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11863.0 BF_2 4.00 0.79 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11864.0 BF_2 9.00 0.39 1252 499002174 XP_004534773.1 523 1.8e-50 PREDICTED: cofilin/actin-depolymerizing factor homolog [Ceratitis capitata] 338224338 HM217810.1 365 0 Scylla paramamosain actin-depolymerizing factor 4-like mRNA, partial sequence K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 517 3.8e-51 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1735 Actin depolymerizing factor Cluster-11867.0 BF_2 31.00 0.87 1774 91089113 XP_972237.1 966 1.1e-101 PREDICTED: pickpocket protein 28 [Tribolium castaneum]>gi|270012423|gb|EFA08871.1| hypothetical protein TcasGA2_TC006572 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86LG1 457 4.8e-44 Pickpocket protein 28 OS=Drosophila melanogaster GN=ppk28 PE=1 SV=2 PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-11871.0 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11877.0 BF_2 3.00 0.57 509 -- -- -- -- -- 462339191 APGK01036907.1 230 3.03945e-115 Dendroctonus ponderosae Seq01036917, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11879.0 BF_2 24.37 0.66 1836 241708208 XP_002413321.1 869 2.0e-90 LIM domain-binding protein, putative [Ixodes scapularis]>gi|215507135|gb|EEC16629.1| LIM domain-binding protein, putative, partial [Ixodes scapularis] 338224401 HM217844.1 467 0 Scylla paramamosain LIM domain-binding protein-like mRNA, partial sequence -- -- -- -- A1ZA47 812 3.4e-85 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00412//PF00020 LIM domain//TNFR/NGFR cysteine-rich region -- -- GO:0016740//GO:0008270//GO:0005515//GO:0046872 transferase activity//zinc ion binding//protein binding//metal ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-11880.0 BF_2 7.00 0.43 962 700894661 AIU99749.1 376 1.6e-33 mitochondrial cytochrome c oxidase subunit VIb [Litopenaeus vannamei] 392303568 JX102601.1 436 0 Scylla paramamosain microsatellite Spm30 sequence K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 O94581 258 3.1e-21 Cytochrome c oxidase subunit 6B OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=cox12 PE=3 SV=2 PF02297//PF02072 Cytochrome oxidase c subunit VIb//Prepro-orexin GO:0007631//GO:0007218//GO:0006123//GO:0015992 feeding behavior//neuropeptide signaling pathway//mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005739//GO:0045277 mitochondrion//respiratory chain complex IV KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-11884.0 BF_2 9.57 3.45 402 478260022 ENN79811.1 169 6.6e-10 hypothetical protein YQE_03752, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11888.0 BF_2 7.00 0.75 675 3287776 P81388.1 274 7.4e-22 RecName: Full=Cuticle protein AMP4; AltName: Full=HA-AMP4 [Homarus americanus] -- -- -- -- -- -- -- -- -- P81576 302 1.7e-26 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF02214//PF00379 BTB/POZ domain//Insect cuticle protein GO:0051260 protein homooligomerization GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-11889.1 BF_2 5.00 0.42 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622 zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-11891.0 BF_2 3.00 0.43 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11893.0 BF_2 1.00 0.96 321 391346824 XP_003747668.1 296 9.9e-25 PREDICTED: 17-beta-hydroxysteroid dehydrogenase type 6-like [Metaseiulus occidentalis] -- -- -- -- -- K00019 E1.1.1.30, bdh 3-hydroxybutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00019 Q80XN0 165 6.3e-11 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Mus musculus GN=Bdh1 PE=1 SV=2 PF00106//PF10414 short chain dehydrogenase//Sirohaem synthase dimerisation region GO:0055114//GO:0006779//GO:0008152 oxidation-reduction process//porphyrin-containing compound biosynthetic process//metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-11898.0 BF_2 3.00 0.31 691 328900032 AEB54654.1 268 3.8e-21 ATPase inhibitory factor 1 [Procambarus clarkii] -- -- -- -- -- -- -- -- -- A8XZB0 157 1.2e-09 ATPase inhibitor mai-2, mitochondrial OS=Caenorhabditis briggsae GN=mai-2 PE=3 SV=1 PF04568 Mitochondrial ATPase inhibitor, IATP GO:0032780 negative regulation of ATPase activity GO:0042030 ATPase inhibitor activity GO:0005739 mitochondrion -- -- Cluster-11900.0 BF_2 2.00 0.40 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-11909.1 BF_2 2.00 0.33 539 871236864 XP_005099774.2 409 1.3e-37 PREDICTED: ligand of Numb protein X 2-like [Aplysia californica] -- -- -- -- -- K10692 LNX1_2 ligand of Numb protein X 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10692 Q8N448 294 1.2e-25 Ligand of Numb protein X 2 OS=Homo sapiens GN=LNX2 PE=1 SV=1 PF00097//PF12678//PF17123//PF14634//PF04564//PF02176//PF03854//PF03145//PF13639//PF15965 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//U-box domain//TRAF-type zinc finger//P-11 zinc finger//Seven in absentia protein family//Ring finger domain//TRAF-like zinc-finger GO:0006511//GO:0007275//GO:0016567 ubiquitin-dependent protein catabolic process//multicellular organismal development//protein ubiquitination GO:0008270//GO:0046872//GO:0003723//GO:0005515//GO:0004842 zinc ion binding//metal ion binding//RNA binding//protein binding//ubiquitin-protein transferase activity GO:0005634 nucleus -- -- Cluster-11916.0 BF_2 26.64 2.36 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11920.0 BF_2 5.00 1.28 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11924.0 BF_2 5.25 0.98 510 157115780 XP_001652693.1 168 1.1e-09 AAEL007344-PA [Aedes aegypti]>gi|108876761|gb|EAT40986.1| AAEL007344-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11929.0 BF_2 4.00 1.89 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11930.0 BF_2 2.00 0.41 491 817196235 XP_012273693.1 547 1.2e-53 PREDICTED: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 isoform X2 [Orussus abietinus] -- -- -- -- -- -- -- -- -- P34595 227 6.2e-18 Immunoglobulin domain and leucine-rich repeat-containing protein 2 OS=Caenorhabditis elegans GN=iglr-2 PE=1 SV=2 PF14943//PF02601//PF07571//PF01017//PF01516//PF07352 Mitochondrial ribosome subunit S26//Exonuclease VII, large subunit//TAF6 C-terminal HEAT repeat domain//STAT protein, all-alpha domain//Orbivirus helicase VP6//Bacteriophage Mu Gam like protein GO:0051090//GO:0007165//GO:0042262//GO:0006308//GO:0006355 regulation of sequence-specific DNA binding transcription factor activity//signal transduction//DNA protection//DNA catabolic process//regulation of transcription, DNA-templated GO:0005198//GO:0008855//GO:0003690//GO:0003700//GO:0004871 structural molecule activity//exodeoxyribonuclease VII activity//double-stranded DNA binding//transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005667//GO:0005763//GO:0019028//GO:0005634//GO:0009318 transcription factor complex//mitochondrial small ribosomal subunit//viral capsid//nucleus//exodeoxyribonuclease VII complex -- -- Cluster-11947.0 BF_2 6.00 3.87 347 762081924 XP_011422687.1 196 4.2e-13 PREDICTED: nidogen-2-like [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region -- -- Cluster-11951.0 BF_2 6.00 0.54 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11952.0 BF_2 4.00 0.35 764 321469998 EFX80976.1 936 1.4e-98 hypothetical protein DAPPUDRAFT_303689 [Daphnia pulex] 462322319 APGK01042890.1 40 1.94443e-09 Dendroctonus ponderosae Seq01042900, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11953.0 BF_2 86.13 3.44 1334 571330962 AHF27413.1 737 3.0e-75 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q291H8 271 1.3e-22 Facilitated trehalose transporter Tret1 OS=Drosophila pseudoobscura pseudoobscura GN=Tret1 PE=3 SV=3 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-11955.0 BF_2 1.00 0.61 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11962.0 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11967.1 BF_2 25.26 0.48 2477 642915103 XP_008190411.1 610 3.0e-60 PREDICTED: uncharacterized protein LOC103312184 isoform X1 [Tribolium castaneum]>gi|642915107|ref|XP_008190412.1| PREDICTED: uncharacterized protein LOC103312184 isoform X1 [Tribolium castaneum] 462418379 APGK01017096.1 69 4.92117e-25 Dendroctonus ponderosae Seq01017106, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF15216 Thymic stromal lymphopoietin GO:0007165 signal transduction GO:0005125 cytokine activity -- -- -- -- Cluster-11983.1 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11990.0 BF_2 15.36 2.12 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-11991.0 BF_2 4.00 0.34 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12007.0 BF_2 4.00 0.45 663 675388247 KFM81144.1 806 1.5e-83 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase, partial [Stegodyphus mimosarum] 768937757 XM_003970462.2 160 3.28464e-76 PREDICTED: Takifugu rubripes O-linked N-acetylglucosamine (GlcNAc) transferase (ogt), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 763 5.9e-80 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13414//PF13176//PF13371//PF00515//PF13374//PF13174//PF10590//PF07721//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0055114 oxidation-reduction process GO:0042802//GO:0005515//GO:0016638 identical protein binding//protein binding//oxidoreductase activity, acting on the CH-NH2 group of donors -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-12013.0 BF_2 4.00 0.37 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12014.0 BF_2 12.00 1.98 541 237843137 XP_002370866.1 517 3.9e-50 60S ribosomal protein L10a, putative [Toxoplasma gondii ME49]>gi|675129528|ref|XP_008886651.1| ribosomal protein RPL10A [Hammondia hammondi]>gi|523573249|gb|EPR60056.1| ribosomal protein RPL10A [Toxoplasma gondii GT1]>gi|527309810|gb|EPT26445.1| ribosomal protein RPL10A [Toxoplasma gondii ME49]>gi|557735154|gb|ESS31213.1| ribosomal protein RPL10A [Toxoplasma gondii VEG]>gi|661334548|gb|KEP62692.1| ribosomal protein RPL10A [Hammondia hammondi]>gi|672261763|gb|KFG36127.1| ribosomal protein RPL10A [Toxoplasma gondii GAB2-2007-GAL-DOM2]>gi|672268287|gb|KFG41367.1| ribosomal protein RPL10A [Toxoplasma gondii p89]>gi|672283299|gb|KFG52829.1| ribosomal protein RPL10A [Toxoplasma gondii FOU]>gi|672298044|gb|KFG62134.1| ribosomal protein RPL10A [Toxoplasma gondii RUB]>gi|672568230|gb|KFH08006.1| ribosomal protein RPL10A [Toxoplasma gondii VAND]>gi|672578965|gb|KFH16504.1| ribosomal protein RPL10A [Toxoplasma gondii MAS]>gi|820701385|tpe|CEL77119.1| TPA: 60S ribosomal protein L10a, putative [Toxoplasma gondii VEG] 659667821 NM_001294174.1 439 0 Zea mays uncharacterized LOC100272335 (LOC100272335), mRNA K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 B7F845 659 5.5e-68 60S ribosomal protein L10a OS=Oryza sativa subsp. japonica GN=RPL10A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1570 60S ribosomal protein L10A Cluster-12016.0 BF_2 4.00 1.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12021.0 BF_2 1.00 2.39 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12023.0 BF_2 2.00 0.49 458 221123420 XP_002155721.1 267 3.2e-21 PREDICTED: thioredoxin domain-containing protein 17-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- Q9BRA2 216 1.1e-16 Thioredoxin domain-containing protein 17 OS=Homo sapiens GN=TXNDC17 PE=1 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG3425 Uncharacterized conserved protein Cluster-12025.0 BF_2 1.00 0.48 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12026.0 BF_2 3.00 0.32 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12030.0 BF_2 2.00 0.53 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12033.0 BF_2 5.00 0.32 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12034.0 BF_2 8.00 0.88 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12034.1 BF_2 4.00 0.71 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12034.2 BF_2 30.00 0.80 1851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01300 Telomere recombination -- -- GO:0003725 double-stranded RNA binding -- -- -- -- Cluster-12042.0 BF_2 2.00 1.29 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12051.0 BF_2 6.00 0.80 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12053.0 BF_2 12.00 0.74 964 391337456 XP_003743084.1 658 3.1e-66 PREDICTED: troponin C-like isoform 1 [Metaseiulus occidentalis] 391342469 XM_003745495.1 218 2.78162e-108 PREDICTED: Metaseiulus occidentalis troponin C-like (LOC100900275), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P15159 599 9.0e-61 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13202//PF00036//PF03461//PF12763//PF00844//PF13833//PF13405//PF13499 EF hand//EF hand//TRCF domain//Cytoskeletal-regulatory complex EF hand//Geminivirus coat protein/nuclear export factor BR1 family//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0006281 DNA repair GO:0005198//GO:0005515//GO:0005509 structural molecule activity//protein binding//calcium ion binding GO:0019028 viral capsid KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-12055.0 BF_2 3.00 0.40 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12056.0 BF_2 5.00 0.54 674 79160090 AAI07895.1 808 8.9e-84 NME1-NME2 protein [Homo sapiens]>gi|119614969|gb|EAW94563.1| hCG2001850, isoform CRA_a [Homo sapiens]>gi|649135086|gb|AIC58793.1| NME1-NME2, partial [synthetic construct] 310923124 NM_002512.3 641 0 Homo sapiens NME/NM23 nucleoside diphosphate kinase 2 (NME2), transcript variant 1, mRNA K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P22392 803 1.4e-84 Nucleoside diphosphate kinase B OS=Homo sapiens GN=NME2 PE=1 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006183//GO:0006144//GO:0006241//GO:0006206//GO:0006165//GO:0006228 GTP biosynthetic process//purine nucleobase metabolic process//CTP biosynthetic process//pyrimidine nucleobase metabolic process//nucleoside diphosphate phosphorylation//UTP biosynthetic process GO:0005524//GO:0004550 ATP binding//nucleoside diphosphate kinase activity GO:0005737 cytoplasm KOG0888 Nucleoside diphosphate kinase Cluster-12069.0 BF_2 1.00 1.37 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12071.1 BF_2 9.00 0.55 971 312190935 ADQ43366.1 718 3.5e-73 HMGBa [Litopenaeus vannamei] 755987004 XM_011313072.1 44 1.49149e-11 PREDICTED: Fopius arisanus high mobility group protein DSP1 (LOC105271495), transcript variant X2, mRNA K10802 HMGB1 high mobility group protein B1 http://www.genome.jp/dbget-bin/www_bget?ko:K10802 Q24537 494 1.4e-48 High mobility group protein DSP1 OS=Drosophila melanogaster GN=Dsp1 PE=2 SV=1 PF06524//PF00178//PF04690//PF02936 NOA36 protein//Ets-domain//YABBY protein//Cytochrome c oxidase subunit IV GO:0006123//GO:0007275//GO:0015992//GO:0006355 mitochondrial electron transport, cytochrome c to oxygen//multicellular organismal development//proton transport//regulation of transcription, DNA-templated GO:0003700//GO:0004129//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//cytochrome-c oxidase activity//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0045277//GO:0005634 transcription factor complex//respiratory chain complex IV//nucleus KOG0381 HMG box-containing protein Cluster-12076.0 BF_2 4.00 0.56 585 646708822 KDR14969.1 542 5.4e-53 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [Zootermopsis nevadensis] -- -- -- -- -- K03965 NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03965 Q0MQE9 325 3.2e-29 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Gorilla gorilla gorilla GN=NDUFB9 PE=2 SV=3 PF09452//PF02628 ESCRT-I subunit Mvb12//Cytochrome oxidase assembly protein GO:0055114//GO:0032509//GO:0006784 oxidation-reduction process//endosome transport via multivesicular body sorting pathway//heme a biosynthetic process GO:0016627//GO:0043130 oxidoreductase activity, acting on the CH-CH group of donors//ubiquitin binding GO:0000813//GO:0016021 ESCRT I complex//integral component of membrane KOG3466 NADH:ubiquinone oxidoreductase, NDUFB9/B22 subunit Cluster-12078.0 BF_2 3.00 1.01 410 655697654 XP_002710659.2 323 9.3e-28 PREDICTED: tribbles homolog 1 [Oryctolagus cuniculus] -- -- -- -- -- K08814 TRIB1_2 tribbles homolog 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08814 Q96RU8 317 1.9e-28 Tribbles homolog 1 OS=Homo sapiens GN=TRIB1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0583 Serine/threonine protein kinase Cluster-12081.0 BF_2 18.00 0.94 1092 475051484 AGI56293.1 137 9.2e-06 thrombospondin II [Penaeus monodon] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-12082.0 BF_2 35.00 8.97 450 238625711 ACR48137.1 642 1.0e-64 ribosomal protein S24 [Rimicaris exoculata] 225711521 BT077183.1 144 1.70789e-67 Caligus rogercresseyi clone crog-evp-503-233 40S ribosomal protein S15Aa putative mRNA, complete cds K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 Q6XIM8 618 2.6e-63 40S ribosomal protein S15a OS=Drosophila yakuba GN=RpS15Aa PE=2 SV=3 PF00410 Ribosomal protein S8 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-12083.0 BF_2 3.00 7.97 274 28316886 AAL68340.2 278 1.0e-22 RH06643p, partial [Drosophila melanogaster] 338224478 HM217888.1 161 3.50021e-77 Scylla paramamosain ribosomal protein S29 CG8495-PA-like protein-like mRNA, partial sequence K02980 RP-S29e, RPS29 small subunit ribosomal protein S29e http://www.genome.jp/dbget-bin/www_bget?ko:K02980 Q9VH69 269 4.6e-23 40S ribosomal protein S29 OS=Drosophila melanogaster GN=RpS29 PE=1 SV=1 PF00253 Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3506 40S ribosomal protein S29 Cluster-12084.0 BF_2 23.00 21.31 323 769857127 XP_011640188.1 381 1.4e-34 PREDICTED: 60S ribosomal protein L37a [Pogonomyrmex barbatus] 545364453 XM_005647230.1 62 4.55273e-22 Coccomyxa subellipsoidea C-169 60S ribosomal protein L37a mRNA K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 O61598 377 1.7e-35 60S ribosomal protein L37a OS=Ostertagia ostertagi GN=rpl-37a PE=3 SV=3 PF01780//PF10717 Ribosomal L37ae protein family//Occlusion-derived virus envelope protein ODV-E18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0019031 intracellular//ribosome//viral envelope KOG0402 60S ribosomal protein L37 Cluster-12097.0 BF_2 3.00 0.45 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12099.0 BF_2 18.00 2.81 555 442738959 AGC69739.1 294 2.9e-24 mannose-1-phosphate guanylyltransferase [Dictyostelium lacteum] 645255407 XM_008235267.1 176 3.46996e-85 PREDICTED: Prunus mume mannose-1-phosphate guanylyltransferase 1 (LOC103332527), transcript variant X2, mRNA K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q84JH5 440 1.4e-42 Probable mannose-1-phosphate guanylyltransferase 1 OS=Oryza sativa subsp. japonica GN=Os03g0268400 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-12109.0 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12109.1 BF_2 3.00 0.36 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12111.0 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12122.0 BF_2 16.00 0.61 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12126.0 BF_2 7.00 0.78 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12131.0 BF_2 10.00 0.39 1355 443711829 ELU05417.1 1564 3.9e-171 hypothetical protein CAPTEDRAFT_177589 [Capitella teleta] 334362268 HQ441033.1 106 7.18968e-46 Epinephelus coioides betaine homocysteine S-methyltansferase mRNA, partial cds K00544 BHMT betaine-homocysteine S-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00544 Q5I597 1482 5.1e-163 Betaine--homocysteine S-methyltransferase 1 OS=Bos taurus GN=BHMT PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-12143.0 BF_2 7.48 0.63 786 642938411 XP_008191057.1 585 7.5e-58 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q9Y5Y0 373 1.2e-34 Feline leukemia virus subgroup C receptor-related protein 1 OS=Homo sapiens GN=FLVCR1 PE=1 SV=1 PF01891//PF00083//PF03137//PF07690 Cobalt uptake substrate-specific transmembrane region//Sugar (and other) transporter//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006810//GO:0055085//GO:0000041 transport//transmembrane transport//transition metal ion transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-12144.0 BF_2 2.00 0.72 402 391345764 XP_003747153.1 521 1.0e-50 PREDICTED: T-complex protein 1 subunit beta-like [Metaseiulus occidentalis] -- -- -- -- -- K09494 CCT2 T-complex protein 1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K09494 Q5XIM9 474 1.2e-46 T-complex protein 1 subunit beta OS=Rattus norvegicus GN=Cct2 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0363 Chaperonin complex component, TCP-1 beta subunit (CCT2) Cluster-12146.0 BF_2 3.00 0.87 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12151.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12152.0 BF_2 2.00 0.53 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12159.0 BF_2 9.00 1.13 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12164.0 BF_2 3.00 0.47 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12180.2 BF_2 2.00 0.52 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12182.0 BF_2 8.00 0.84 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12195.0 BF_2 1.00 0.90 325 -- -- -- -- -- 55296639 AP006751.2 307 2.92757e-158 Oryza sativa Japonica Group genomic DNA, chromosome 6, BAC clone:B1460A05 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12199.0 BF_2 26.00 0.68 1890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12200.0 BF_2 2.00 0.35 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12203.0 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12204.1 BF_2 10.00 2.44 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12205.0 BF_2 6.00 0.50 792 356651196 AET34915.1 163 6.5e-09 heat shock protein 21 [Macrobrachium rosenbergii] -- -- -- -- -- -- -- -- -- P02516 137 2.8e-07 Heat shock protein 23 OS=Drosophila melanogaster GN=Hsp23 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-12209.0 BF_2 8.00 0.51 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12214.0 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12222.0 BF_2 2.00 0.33 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12225.0 BF_2 2.00 0.33 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12227.1 BF_2 4.00 0.38 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12244.0 BF_2 3.00 0.58 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12247.0 BF_2 4.00 0.65 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12249.0 BF_2 5.00 0.67 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12256.0 BF_2 4.00 0.43 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12256.1 BF_2 4.00 1.42 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12259.0 BF_2 4.00 6.51 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12260.0 BF_2 2.00 0.31 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12263.0 BF_2 11.00 0.37 1518 328796226 AEB40302.1 1250 1.1e-134 mitochondrial ATP synthase gamma subunit precursor [Litopenaeus vannamei] 577029966 KF648350.1 59 1.08251e-19 Biomphalaria glabrata ATP synthase subunit mitochondrial-like protein mRNA, partial cds K02136 ATPeF1G, ATP5C1, ATP3 F-type H+-transporting ATPase subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K02136 O01666 926 1.7e-98 ATP synthase subunit gamma, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-gamma PE=2 SV=2 PF00231 ATP synthase GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1531 F0F1-type ATP synthase, gamma subunit Cluster-12273.0 BF_2 4.00 0.65 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12278.1 BF_2 15.12 0.33 2208 478262797 ENN81314.1 1050 2.5e-111 hypothetical protein YQE_02282, partial [Dendroctonus ponderosae]>gi|546672918|gb|ERL84634.1| hypothetical protein D910_02062 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P30543 328 5.5e-29 Adenosine receptor A2a OS=Rattus norvegicus GN=Adora2a PE=1 SV=2 PF07123//PF00001 Photosystem II reaction centre W protein (PsbW)//7 transmembrane receptor (rhodopsin family) GO:0015979//GO:0007186 photosynthesis//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0009507//GO:0016021//GO:0009523 chloroplast//integral component of membrane//photosystem II -- -- Cluster-12279.0 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12279.1 BF_2 6.00 0.40 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12282.0 BF_2 4.00 1.38 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12289.0 BF_2 5.00 1.25 454 668462699 KFB50168.1 214 4.5e-15 hypothetical protein ZHAS_00018231 [Anopheles sinensis] 702460305 XM_010029647.1 156 3.67996e-74 PREDICTED: Eucalyptus grandis mitochondrial uncoupling protein 5 (LOC104418328), mRNA K15106 SLC25A14_30 solute carrier family 25 (mitochondrial carrier), member 14/30 http://www.genome.jp/dbget-bin/www_bget?ko:K15106 Q9SJY5 321 7.2e-29 Mitochondrial uncoupling protein 5 OS=Arabidopsis thaliana GN=PUMP5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-12294.1 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12299.0 BF_2 2.00 0.77 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12303.0 BF_2 4.00 0.41 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12303.1 BF_2 3.00 0.39 608 642921203 XP_008192760.1 150 1.6e-07 PREDICTED: uncharacterized protein LOC103312841 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12304.0 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12308.0 BF_2 6.00 0.65 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12308.1 BF_2 8.00 0.49 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12309.0 BF_2 12.00 1.81 565 744603787 XP_010991488.1 860 6.9e-90 PREDICTED: 40S ribosomal protein S11 [Camelus dromedarius] 395132454 NM_001015.4 565 0 Homo sapiens ribosomal protein S11 (RPS11), mRNA K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P62280 824 4.3e-87 40S ribosomal protein S11 OS=Homo sapiens GN=RPS11 PE=1 SV=3 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1728 40S ribosomal protein S11 Cluster-12320.0 BF_2 1.00 0.69 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12340.0 BF_2 6.00 0.40 916 662215753 XP_008481775.1 665 4.6e-67 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q8I7P9 147 2.2e-08 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-12349.0 BF_2 3.00 1.01 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12351.1 BF_2 1.00 0.88 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12352.0 BF_2 2.00 0.60 427 725571770 XP_010338387.1 564 1.1e-55 PREDICTED: LOW QUALITY PROTEIN: 60S ribosomal protein L34 [Saimiri boliviensis boliviensis] 578809310 XM_005263172.2 426 0 PREDICTED: Homo sapiens ribosomal protein L34 (RPL34), transcript variant X1, mRNA K02915 RP-L34e, RPL34 large subunit ribosomal protein L34e http://www.genome.jp/dbget-bin/www_bget?ko:K02915 P49207 524 2.0e-52 60S ribosomal protein L34 OS=Homo sapiens GN=RPL34 PE=1 SV=3 PF08534//PF01199 Redoxin//Ribosomal protein L34e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0016491 structural constituent of ribosome//oxidoreductase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1790 60s ribosomal protein L34 Cluster-12353.0 BF_2 8.00 0.37 1198 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12353.1 BF_2 4.00 1.04 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12362.1 BF_2 23.00 0.51 2192 642931676 XP_008196683.1 173 1.2e-09 PREDICTED: uncharacterized protein LOC103313928 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-12367.0 BF_2 1.00 0.32 416 -- -- -- -- -- 768311752 CP010980.1 416 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12370.0 BF_2 15.00 0.37 1980 758213860 AJO62243.1 1415 1.1e-153 chemosensory ionotropic receptor IR5 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q61625 240 7.8e-19 Glutamate receptor ionotropic, delta-2 OS=Mus musculus GN=Grid2 PE=1 SV=1 PF00060//PF10613//PF06682 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//SOCE-associated regulatory factor of calcium homoeostasis GO:0006811//GO:0007268//GO:2001256//GO:0007165 ion transport//synaptic transmission//regulation of store-operated calcium entry//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020//GO:0030176 membrane//integral component of endoplasmic reticulum membrane -- -- Cluster-12377.0 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12378.0 BF_2 6.00 0.39 927 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10596 U6-snRNA interacting domain of PrP8 -- -- GO:0017070 U6 snRNA binding -- -- -- -- Cluster-12397.0 BF_2 2.00 0.35 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12411.0 BF_2 3.00 0.60 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12419.0 BF_2 2.00 0.67 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12420.0 BF_2 7.00 5.70 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12424.0 BF_2 3.00 0.46 559 646707201 KDR14062.1 375 1.2e-33 hypothetical protein L798_11975 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6INX1 309 2.2e-27 Transmembrane protein 98 OS=Xenopus laevis GN=tmem98 PE=2 SV=1 PF01561 Hantavirus glycoprotein G2 GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0019012 virion -- -- Cluster-12427.0 BF_2 3.00 0.39 611 309242901 BAJ22990.1 529 1.8e-51 cytochrome c [Marsupenaeus japonicus] -- -- -- -- -- K08738 CYC cytochrome c http://www.genome.jp/dbget-bin/www_bget?ko:K08738 Q6QLW4 495 6.5e-49 Cytochrome c OS=Pectinaria gouldii PE=3 SV=1 PF13442//PF00034 Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome c GO:0006118 obsolete electron transport GO:0020037//GO:0009055 heme binding//electron carrier activity -- -- KOG3453 Cytochrome c Cluster-12429.0 BF_2 2.00 0.56 436 241729451 XP_002412260.1 341 8.1e-30 translation initiation factor 2C, putative [Ixodes scapularis]>gi|215505489|gb|EEC14983.1| translation initiation factor 2C, putative [Ixodes scapularis] -- -- -- -- -- K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 O77503 335 1.7e-30 Protein argonaute-2 (Fragment) OS=Oryctolagus cuniculus GN=AGO2 PE=1 SV=2 PF02170 PAZ domain -- -- GO:0005515 protein binding -- -- KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-12430.0 BF_2 2.00 0.39 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12440.0 BF_2 9.00 0.32 1478 391330946 XP_003739912.1 701 5.0e-71 PREDICTED: phosphatidylethanolamine-binding protein homolog F40A3.3-like isoform 2 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- O16264 554 2.3e-55 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 PF06734 UL97 GO:0016032 viral process GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-12441.0 BF_2 1.00 0.33 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01213//PF05038 Adenylate cyclase associated (CAP) N terminal//Cytochrome Cytochrome b558 alpha-subunit GO:0007010 cytoskeleton organization GO:0020037//GO:0003779 heme binding//actin binding -- -- -- -- Cluster-12446.0 BF_2 22.00 1.98 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12451.0 BF_2 3.00 0.73 458 821030051 XP_012359262.1 302 2.8e-25 PREDICTED: 60S acidic ribosomal protein P2 isoform X2 [Nomascus leucogenys] 78217389 NM_001004.3 454 0 Homo sapiens ribosomal protein, large, P2 (RPLP2), mRNA K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P05387 302 1.2e-26 60S acidic ribosomal protein P2 OS=Homo sapiens GN=RPLP2 PE=1 SV=1 PF03540 Transcription initiation factor TFIID 23-30kDa subunit GO:0006352 DNA-templated transcription, initiation -- -- GO:0005634 nucleus KOG3449 60S acidic ribosomal protein P2 Cluster-12456.0 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12457.0 BF_2 7.00 0.36 1104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12461.0 BF_2 5.00 0.37 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12464.0 BF_2 1.00 2.06 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12466.0 BF_2 2.00 0.31 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12475.0 BF_2 8.00 0.35 1235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0050912//GO:0007187//GO:0050909//GO:0007607 detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-12494.0 BF_2 2.00 0.41 490 805823179 XP_012151570.1 425 1.7e-39 PREDICTED: ELAV-like protein 1 isoform X2 [Megachile rotundata] 645001491 XM_008211331.1 185 3.0232e-90 PREDICTED: Nasonia vitripennis ELAV-like protein 1 (LOC100119488), transcript variant X9, mRNA K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 Q7SZT7 374 5.6e-35 ELAV-like protein 4 OS=Xenopus laevis GN=elavl4 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-12504.0 BF_2 16.00 6.29 392 328899610 AEB54642.1 468 1.4e-44 ribosomal protein L35 [Procambarus clarkii] 262401437 FJ774901.1 388 0 Scylla paramamosain ribosomal protein L35 mRNA, complete cds K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 Q6ZWV7 351 2.1e-32 60S ribosomal protein L35 OS=Mus musculus GN=Rpl35 PE=2 SV=1 PF00831//PF00466 Ribosomal L29 protein//Ribosomal protein L10 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3436 60S ribosomal protein L35 Cluster-12506.0 BF_2 2.00 1.38 342 470306014 XP_004363340.1 171 3.3e-10 hypothetical protein CAOG_03612 [Capsaspora owczarzaki ATCC 30864]>gi|765552076|gb|KJE92697.1| hypothetical protein CAOG_003612 [Capsaspora owczarzaki ATCC 30864] 697076615 XM_009654199.1 302 1.86452e-155 Verticillium dahliae VdLs.17 NADH:ubiquinone oxidoreductase 11.5kD subunit partial mRNA -- -- -- -- -- -- -- -- PF02297//PF00941 Cytochrome oxidase c subunit VIb//FAD binding domain in molybdopterin dehydrogenase GO:0006123//GO:0055114//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//oxidation-reduction process//proton transport GO:0016491//GO:0004129 oxidoreductase activity//cytochrome-c oxidase activity GO:0045277//GO:0005739 respiratory chain complex IV//mitochondrion -- -- Cluster-12507.0 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12513.0 BF_2 3.00 0.43 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12514.0 BF_2 5.00 2.32 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12516.0 BF_2 2.25 0.35 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12527.0 BF_2 7.00 0.68 717 297260431 XP_002798294.1 1008 6.1e-107 PREDICTED: hypothetical protein LOC100430699 isoform 1 [Macaca mulatta]>gi|297260433|ref|XP_002798295.1| PREDICTED: hypothetical protein LOC100430699 isoform 2 [Macaca mulatta] 10439451 AK026569.1 717 0 Homo sapiens cDNA: FLJ22916 fis, clone KAT06406, highly similar to HSCYCR Human mRNA for T-cell cyclophilin K03767 PPIA peptidyl-prolyl cis-trans isomerase A (cyclophilin A) http://www.genome.jp/dbget-bin/www_bget?ko:K03767 P62937 886 3.5e-94 Peptidyl-prolyl cis-trans isomerase A OS=Homo sapiens GN=PPIA PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- -- -- Cluster-12531.0 BF_2 2.00 0.38 507 -- -- -- -- -- 573984618 XM_006670167.1 39 4.54236e-09 Cordyceps militaris CM01 hypothetical protein (CCM_05022), partial mRNA -- -- -- -- -- -- -- -- PF16934//PF00272//PF01557 Two-component Enterococcus faecalis cytolysin (EFC)//Cecropin family//Fumarylacetoacetate (FAA) hydrolase family GO:0050830//GO:0008152 defense response to Gram-positive bacterium//metabolic process GO:0003824 catalytic activity GO:0005576 extracellular region -- -- Cluster-12547.0 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12548.0 BF_2 15.00 0.35 2105 642929675 XP_008195931.1 392 4.8e-35 PREDICTED: uncharacterized protein LOC103313712 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12552.0 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12554.0 BF_2 3.00 0.64 483 326922381 XP_003207427.1 610 5.8e-61 PREDICTED: bifunctional purine biosynthesis protein PURH [Meleagris gallopavo] 746843127 XM_011053486.1 50 3.31016e-15 PREDICTED: Acromyrmex echinatior bifunctional purine biosynthesis protein PURH (LOC105144531), mRNA K00602 purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K00602 P31335 609 3.1e-62 Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1 PF01808 AICARFT/IMPCHase bienzyme GO:0006164//GO:0006807//GO:0006144 purine nucleotide biosynthetic process//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0004643//GO:0003937 phosphoribosylaminoimidazolecarboxamide formyltransferase activity//IMP cyclohydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG2555 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase Cluster-12556.0 BF_2 5.00 0.70 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12562.0 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12564.0 BF_2 16.00 1.43 755 187179331 NP_001119643.1 704 1.1e-71 ribosomal protein L12 [Acyrthosiphon pisum]>gi|89574483|gb|ABD76372.1| putative ribosomal protein L12e [Acyrthosiphon pisum]>gi|239788182|dbj|BAH70782.1| ACYPI000059 [Acyrthosiphon pisum] 262401300 FJ774832.1 519 0 Scylla paramamosain ribosomal protein L12 mRNA, complete cds K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61866 661 4.5e-68 60S ribosomal protein L12 OS=Caenorhabditis elegans GN=rpl-12 PE=3 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-12567.0 BF_2 9.00 0.68 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12568.0 BF_2 2.00 0.31 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12571.0 BF_2 6.57 0.45 902 642932613 XP_968153.2 786 4.2e-81 PREDICTED: uncharacterized protein LOC656535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91ZX7 126 5.9e-06 Prolow-density lipoprotein receptor-related protein 1 OS=Mus musculus GN=Lrp1 PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-12573.0 BF_2 24.07 0.40 2778 642932504 XP_008197141.1 675 9.7e-68 PREDICTED: kielin/chordin-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00093//PF12297 von Willebrand factor type C domain//Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway GO:0005515 protein binding -- -- -- -- Cluster-12575.0 BF_2 1.00 0.44 381 470383049 XP_004333917.1 174 1.6e-10 PB1 domain containing protein [Acanthamoeba castellanii str. Neff]>gi|440790623|gb|ELR11904.1| PB1 domain containing protein [Acanthamoeba castellanii str. Neff] 768311753 CP010981.1 381 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- Q9H6K1 153 1.8e-09 Uncharacterized protein C6orf106 OS=Homo sapiens GN=C6orf106 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-12579.0 BF_2 11.22 0.38 1510 157129529 XP_001661710.1 349 3.3e-30 AAEL011513-PA [Aedes aegypti]>gi|108872165|gb|EAT36390.1| AAEL011513-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-12581.0 BF_2 1.00 1.07 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12583.0 BF_2 22.00 4.58 488 268306400 ACY95321.1 305 1.4e-25 ribosomal protein L28 [Manduca sexta] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 293 1.4e-25 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-12585.0 BF_2 4.00 0.64 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12586.0 BF_2 5.00 0.53 680 557751038 XP_005175277.1 429 7.9e-40 PREDICTED: ATP synthase subunit d, mitochondrial-like [Musca domestica]>gi|557772473|ref|XP_005185893.1| PREDICTED: ATP synthase subunit d, mitochondrial-like [Musca domestica]>gi|557772475|ref|XP_005185894.1| PREDICTED: ATP synthase subunit d, mitochondrial-like [Musca domestica] -- -- -- -- -- K02138 ATPeF0D, ATP5H, ATP7 F-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02138 Q24251 381 1.2e-35 ATP synthase subunit d, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-d PE=2 SV=2 PF08202 Mis12-Mtw1 protein family GO:0051301//GO:0007059 cell division//chromosome segregation -- -- GO:0000444 MIS12/MIND type complex KOG3366 Mitochondrial F1F0-ATP synthase, subunit d/ATP7 Cluster-12592.0 BF_2 6.00 0.56 734 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12595.0 BF_2 3.00 0.33 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12607.0 BF_2 4.00 0.33 792 827563622 XP_012552354.1 185 1.8e-11 PREDICTED: uncharacterized protein LOC105842693 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12615.0 BF_2 2.00 0.41 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12616.0 BF_2 5.00 0.76 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12617.0 BF_2 2.00 0.81 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12628.0 BF_2 4.52 0.44 718 -- -- -- -- -- 88605020 DQ386641.1 265 1.52656e-134 Apriona germari transferrin gene, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12637.0 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09367 CpeS-like protein GO:0017009 protein-phycocyanobilin linkage -- -- -- -- -- -- Cluster-12648.0 BF_2 13.00 0.46 1468 478255344 ENN75570.1 521 3.7e-50 hypothetical protein YQE_07913, partial [Dendroctonus ponderosae] -- -- -- -- -- K10420 DYNLT dynein light chain Tctex-type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10420 Q94524 399 2.1e-37 Dynein light chain Tctex-type OS=Drosophila melanogaster GN=Dlc90F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4081 Dynein light chain Cluster-12652.0 BF_2 43.40 1.46 1532 642931465 XP_008196595.1 1418 3.7e-154 PREDICTED: uncharacterized protein LOC103313903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12660.0 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12663.0 BF_2 24.00 1.69 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371 Diaphanous GTPase-binding Domain GO:0030036 actin cytoskeleton organization GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- -- -- Cluster-12684.0 BF_2 13.00 1.26 720 507713498 XP_004647791.1 892 1.7e-93 PREDICTED: 40S ribosomal protein S5 [Octodon degus] 238231610 NM_001160519.1 219 5.70482e-109 Oncorhynchus mykiss 40S ribosomal protein S5 (rs5), mRNA >gnl|BL_ORD_ID|6534901 Oncorhynchus mykiss clone omyk-evn-501-017 40S ribosomal protein S5 putative mRNA, complete cds K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q5E988 885 4.6e-94 40S ribosomal protein S5 OS=Bos taurus GN=RPS5 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-12689.0 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12697.0 BF_2 3.00 0.38 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12705.0 BF_2 3.00 0.45 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12707.0 BF_2 21.00 1.54 857 544449783 XP_005562405.1 359 1.3e-31 PREDICTED: RAC-alpha serine/threonine-protein kinase isoform X1 [Macaca fascicularis] 440502988 JX512440.1 857 0 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1) gene, complete cds K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 P47196 183 1.4e-12 RAC-alpha serine/threonine-protein kinase OS=Rattus norvegicus GN=Akt1 PE=1 SV=1 PF00433 Protein kinase C terminal domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004674//GO:0005524 protein serine/threonine kinase activity//ATP binding -- -- KOG0690 Serine/threonine protein kinase Cluster-12709.2 BF_2 2.00 0.32 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07497 Rho termination factor, RNA-binding domain GO:0006353 DNA-templated transcription, termination GO:0003723 RNA binding -- -- -- -- Cluster-12711.0 BF_2 41.43 1.25 1677 478262797 ENN81314.1 325 2.2e-27 hypothetical protein YQE_02282, partial [Dendroctonus ponderosae]>gi|546672918|gb|ERL84634.1| hypothetical protein D910_02062 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P53452 155 4.8e-09 D(1)-like dopamine receptor OS=Takifugu rubripes GN=d14 PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-12712.0 BF_2 6.00 0.90 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12723.0 BF_2 2.00 0.40 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11522 Yeast phosphatidylinositol-4-OH kinase Pik1 -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-12727.0 BF_2 3.00 1.35 378 391333929 XP_003741362.1 171 3.6e-10 PREDICTED: uncharacterized protein LOC100903071 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12736.0 BF_2 8.00 0.87 670 751813218 AJG01356.1 568 5.9e-56 cuticular protein 15 [Eriocheir sinensis] -- -- -- -- -- -- -- -- -- P81580 186 4.8e-13 Cuticle protein CP1158 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-12745.0 BF_2 8.73 0.35 1329 241648488 XP_002410067.1 276 8.5e-22 alternative splicing factor SRp20/9G8, putative [Ixodes scapularis]>gi|215501503|gb|EEC10997.1| alternative splicing factor SRp20/9G8, putative [Ixodes scapularis] -- -- -- -- -- K12892 SFRS3 splicing factor, arginine/serine-rich 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12892 Q8BL97 215 4.2e-16 Serine/arginine-rich splicing factor 7 OS=Mus musculus GN=Srsf7 PE=1 SV=1 PF00001//PF16367//PF00076 7 transmembrane receptor (rhodopsin family)//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0007186 G-protein coupled receptor signaling pathway GO:0000166//GO:0004930//GO:0003676 nucleotide binding//G-protein coupled receptor activity//nucleic acid binding GO:0016021 integral component of membrane KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-12747.0 BF_2 5.00 0.35 885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12752.0 BF_2 4.00 0.32 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12759.1 BF_2 8.00 1.18 570 260814835 XP_002602119.1 890 2.3e-93 hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae]>gi|229287425|gb|EEN58131.1| hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae] 761231940 KM881643.1 542 0 Oryza officinalis chloroplast, complete genome K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q6B8S4 879 1.8e-93 ATP synthase subunit beta, chloroplastic OS=Gracilaria tenuistipitata var. liui GN=atpB PE=3 SV=1 PF00006//PF00306 ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta chain, C terminal domain GO:0005975//GO:0015992//GO:0015986//GO:0015991//GO:0006119 carbohydrate metabolic process//proton transport//ATP synthesis coupled proton transport//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0008553//GO:0046933//GO:0016820//GO:0005524//GO:0016757 hydrogen-exporting ATPase activity, phosphorylative mechanism//proton-transporting ATP synthase activity, rotational mechanism//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//ATP binding//transferase activity, transferring glycosyl groups GO:0045259//GO:0033178//GO:0045261 proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain//proton-transporting ATP synthase complex, catalytic core F(1) KOG1350 F0F1-type ATP synthase, beta subunit Cluster-12762.0 BF_2 1.00 1.19 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12762.1 BF_2 9.00 1.20 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12765.0 BF_2 3.00 0.39 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12769.0 BF_2 4.00 0.36 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12769.1 BF_2 5.00 0.37 849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12770.0 BF_2 9.00 0.90 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12777.0 BF_2 3.00 0.41 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12778.0 BF_2 3.00 0.33 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12792.0 BF_2 3.00 1.17 393 3287775 P81387.1 306 8.4e-26 RecName: Full=Cuticle protein AMP3; AltName: Full=HA-AMP3 [Homarus americanus] -- -- -- -- -- -- -- -- -- P81577 339 5.2e-31 Cuticle protein AM1199 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-12795.1 BF_2 14.00 0.44 1612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12806.0 BF_2 3.00 0.44 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12812.0 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12817.0 BF_2 2.00 1.03 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12821.0 BF_2 14.00 0.48 1516 642935654 XP_008198101.1 454 2.2e-42 PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935656|ref|XP_008198102.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935658|ref|XP_008198103.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum] -- -- -- -- -- K07817 PTPRN receptor-type tyrosine-protein phosphatase N http://www.genome.jp/dbget-bin/www_bget?ko:K07817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12824.0 BF_2 2.69 0.36 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12825.0 BF_2 3.00 0.49 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12831.0 BF_2 6.00 0.49 795 641660705 XP_003243557.2 538 2.1e-52 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P86452 207 2.1e-15 Zinc finger BED domain-containing protein 6 OS=Homo sapiens GN=ZBED6 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1121 Tam3-transposase (Ac family) Cluster-12832.0 BF_2 2.00 0.40 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12839.0 BF_2 7.00 2.97 384 321466838 EFX77831.1 257 3.9e-20 hypothetical protein DAPPUDRAFT_305305 [Daphnia pulex] -- -- -- -- -- K02129 ATPeF0E, ATP5I F-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02129 -- -- -- -- PF05680 ATP synthase E chain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG4326 Mitochondrial F1F0-ATP synthase, subunit e Cluster-12847.0 BF_2 9.00 0.39 1258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12855.0 BF_2 3.00 0.32 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12861.0 BF_2 3.00 1.86 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12865.0 BF_2 7.00 0.64 743 260207865 CAY61893.1 935 1.8e-98 60s ribosomal protein L10 [Tityus discrepans] 288783346 AK351230.1 152 1.03671e-71 Sus scrofa mRNA, clone:TES010040D10, expressed in testis K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O61231 834 3.9e-88 60S ribosomal protein L10 OS=Drosophila melanogaster GN=RpL10 PE=1 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-12870.0 BF_2 9.00 0.37 1295 472366416 XP_004402747.1 1991 1.1e-220 PREDICTED: 60S ribosomal protein L3 isoform X1 [Odobenus rosmarus divergens] 78395075 BC107711.1 1295 0 Homo sapiens ribosomal protein L3, mRNA (cDNA clone MGC:104284 IMAGE:6699816), complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 P39023 2046 2.0e-228 60S ribosomal protein L3 OS=Homo sapiens GN=RPL3 PE=1 SV=2 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-12875.0 BF_2 17.00 0.93 1050 391333957 XP_003741376.1 668 2.4e-67 PREDICTED: cathepsin S-like [Metaseiulus occidentalis] -- -- -- -- -- K01371 CTSK cathepsin K http://www.genome.jp/dbget-bin/www_bget?ko:K01371 Q26636 603 3.4e-61 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-12877.0 BF_2 4.00 0.35 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12878.0 BF_2 5.00 0.36 866 498950283 XP_004522991.1 424 3.8e-39 PREDICTED: acyl carrier protein, mitochondrial isoform X1 [Ceratitis capitata] 262401126 FJ774745.1 246 6.77367e-124 Scylla paramamosain acyl carrier protein mRNA, partial cds K03955 NDUFAB1 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03955 Q94519 414 2.3e-39 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 PF03274 Foamy virus BEL 1/2 protein GO:0016032//GO:0045893 viral process//positive regulation of transcription, DNA-templated -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-12882.0 BF_2 5.00 0.99 499 281182984 NP_001162439.1 365 1.5e-32 small EDRK-rich factor 2 [Papio anubis]>gi|548961893|ref|NP_001272226.1| uncharacterized protein LOC101865970 [Macaca fascicularis]>gi|675730634|ref|XP_008966081.1| PREDICTED: small EDRK-rich factor 2 isoform X2 [Pan paniscus]>gi|795266344|ref|XP_011920510.1| PREDICTED: small EDRK-rich factor 2 isoform X3 [Cercocebus atys]>gi|12751386|gb|AAK07636.1|AF320073_1 gastric cancer-related protein VRG107 [Homo sapiens]>gi|67970575|dbj|BAE01630.1| unnamed protein product [Macaca fascicularis]>gi|119597645|gb|EAW77239.1| hCG2003792, isoform CRA_a [Homo sapiens]>gi|119597646|gb|EAW77240.1| hCG2003792, isoform CRA_a [Homo sapiens]>gi|123981184|gb|ABM82421.1| small EDRK-rich factor 2 [synthetic construct]>gi|123996021|gb|ABM85612.1| small EDRK-rich factor 2 [synthetic construct]>gi|163781050|gb|ABY40817.1| small EDRK-rich factor 2 (predicted) [Papio anubis]>gi|166183782|gb|ABY84147.1| small EDRK-rich factor 2 (predicted) [Callithrix jacchus]>gi|649138551|gb|AIC59593.1| SERF2, partial [synthetic construct] 675730637 XM_008967834.1 499 0 PREDICTED: Pan paniscus small EDRK-rich factor 2 (SERF2), transcript variant X3, mRNA -- -- -- -- A5JSS4 217 9.2e-17 Small EDRK-rich factor 2 OS=Capra hircus GN=SERF2 PE=3 SV=1 -- -- -- -- -- -- GO:0005634//GO:0005829 nucleus//cytosol KOG4488 Small EDRK-rich protein H4F5 Cluster-12884.0 BF_2 3.00 0.45 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12899.0 BF_2 2.00 0.52 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12901.0 BF_2 2.00 0.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12904.0 BF_2 8.00 0.36 1213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12906.0 BF_2 6.00 0.42 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12915.0 BF_2 3.00 0.67 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12922.0 BF_2 6.00 0.31 1092 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12929.0 BF_2 1.00 0.31 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12930.0 BF_2 4.00 0.48 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12940.0 BF_2 3.00 0.31 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-12946.0 BF_2 33.00 1.11 1528 546684937 ERL94519.1 840 3.9e-87 hypothetical protein D910_11796 [Dendroctonus ponderosae] 319433937 HQ881802.1 150 2.82313e-70 Culex pipiens complex sp. YL-2011 isolate UL4_M fork head domain transcription factor slp2 (CPIJ020030) gene, exon 2 and partial cds >gnl|BL_ORD_ID|10103406 Culex pipiens complex sp. YL-2011 isolate RD4_M fork head domain transcription factor slp2 (CPIJ020030) gene, exon 2 and partial cds K09385 FOXG forkhead box protein G http://www.genome.jp/dbget-bin/www_bget?ko:K09385 P32031 495 1.6e-48 Fork head domain transcription factor slp2 OS=Drosophila melanogaster GN=slp2 PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-12960.0 BF_2 39.00 2.98 835 761380056 YP_009121388.1 886 9.9e-93 cytochrome c oxidase subunit 3 (mitochondrion) [Thecamonas trahens]>gi|751130543|gb|AJF36621.1| cytochrome c oxidase subunit 3 (mitochondrion) [Thecamonas trahens] 388509857 BT143201.1 769 0 Lotus japonicus clone JCVI-FLLj-14N1 unknown mRNA K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 P15953 1202 9.3e-131 Cytochrome c oxidase subunit 3 OS=Triticum aestivum GN=COX3 PE=2 SV=2 PF00510//PF12179 Cytochrome c oxidase subunit III//I-kappa-kinase-beta NEMO binding domain GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0015002//GO:0008384 heme-copper terminal oxidase activity//IkappaB kinase activity GO:0016020//GO:0008385 membrane//IkappaB kinase complex KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-12962.0 BF_2 5.00 0.42 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445 FR47-like protein -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-12964.0 BF_2 4.00 1.20 426 512393274 AGO02162.1 232 3.4e-17 metallothionein [Scylla paramamosain]>gi|514995423|gb|AGO64127.1| metallothionein [Scylla paramamosain] 512393273 KC757379.1 422 0 Scylla paramamosain metallothionein mRNA, complete cds -- -- -- -- Q9U620 226 7.0e-18 Copper-specific metallothionein-2 OS=Callinectes sapidus PE=3 SV=1 PF06112 Gammaherpesvirus capsid protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-12967.0 BF_2 13.00 0.34 1890 641659698 XP_008181211.1 301 1.5e-24 PREDICTED: uncharacterized protein LOC103308853 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q03270 131 3.3e-06 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 2 (Fragment) OS=Nasonia vitripennis PE=3 SV=1 PF04810 Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-12968.0 BF_2 5.00 0.42 781 861651512 KMQ97842.1 660 1.5e-66 arrestin-like protein [Lasius niger] -- -- -- -- -- K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P32122 648 1.5e-66 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 PF01899 Na+/H+ ion antiporter subunit GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3865 Arrestin Cluster-12981.0 BF_2 3.00 0.45 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-12991.0 BF_2 1.00 1.07 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13003.0 BF_2 6.00 1.22 492 197210357 ACH48186.1 387 4.2e-35 60S ribosomal protein L28 [Haplopelma schmidti] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 P46779 249 1.8e-20 60S ribosomal protein L28 OS=Homo sapiens GN=RPL28 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-13012.0 BF_2 3.00 0.58 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13017.0 BF_2 5.00 0.38 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-13021.0 BF_2 2.00 0.75 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13022.0 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13026.0 BF_2 3.00 0.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13028.0 BF_2 8.00 0.44 1048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13034.1 BF_2 21.00 0.85 1322 642926535 XP_008194910.1 459 5.1e-43 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4-like [Tribolium castaneum]>gi|270009106|gb|EFA05554.1| hypothetical protein TcasGA2_TC015742 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9MZS1 264 8.6e-22 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 OS=Oryctolagus cuniculus GN=HCN1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-13034.2 BF_2 9.00 0.69 836 752875624 XP_011255171.1 185 1.9e-11 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1-like [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02431 Chalcone-flavanone isomerase -- -- GO:0016872 intramolecular lyase activity -- -- -- -- Cluster-13037.0 BF_2 5.00 0.35 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13051.0 BF_2 2.00 0.40 497 817256403 XP_012311900.1 747 7.7e-77 PREDICTED: 26S protease regulatory subunit 7 [Aotus nancymaae] 884976587 XM_010887283.2 196 2.35614e-96 PREDICTED: Esox lucius proteasome (prosome, macropain) 26S subunit, ATPase, 2 (psmc2), mRNA K03061 PSMC2, RPT1 26S proteasome regulatory subunit T1 http://www.genome.jp/dbget-bin/www_bget?ko:K03061 P46472 747 3.2e-78 26S protease regulatory subunit 7 OS=Xenopus laevis GN=psmc2 PE=2 SV=1 PF07724//PF00004//PF00830//PF05496//PF06068//PF00158//PF01695//PF14532//PF07728//PF00910//PF02562//PF01637//PF07726 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Ribosomal L28 family//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//RNA helicase//PhoH-like protein//Archaeal ATPase//ATPase family associated with various cellular activities (AAA) GO:0006281//GO:0042254//GO:0006355//GO:0006310 DNA repair//ribosome biogenesis//regulation of transcription, DNA-templated//DNA recombination GO:0008134//GO:0005524//GO:0003735//GO:0016887//GO:0003723//GO:0003678//GO:0003724//GO:0009378 transcription factor binding//ATP binding//structural constituent of ribosome//ATPase activity//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005840//GO:0005667//GO:0005657 Holliday junction helicase complex//ribosome//transcription factor complex//replication fork KOG0729 26S proteasome regulatory complex, ATPase RPT1 Cluster-13056.0 BF_2 21.37 0.51 2036 751219341 XP_011162750.1 781 3.6e-80 PREDICTED: calpain-A-like isoform X9 [Solenopsis invicta] -- -- -- -- -- K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 727 2.7e-75 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF13499//PF13405//PF13833//PF00036//PF13202//PF00648 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//EF hand//Calpain family cysteine protease GO:0006508 proteolysis GO:0005509//GO:0004198 calcium ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-13062.0 BF_2 5.00 0.45 750 391335714 XP_003742234.1 480 1.1e-45 PREDICTED: uncharacterized protein LOC100901442 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04494 WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-13063.0 BF_2 2.00 0.47 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13066.0 BF_2 1.00 0.43 383 642916891 XP_008199544.1 192 1.3e-12 PREDICTED: WASH complex subunit strumpellin [Tribolium castaneum] -- -- -- -- -- K18464 RTSC, SPG8 WASH complex subunit strumpellin http://www.genome.jp/dbget-bin/www_bget?ko:K18464 Q6DIP9 160 2.9e-10 WASH complex subunit strumpellin OS=Xenopus tropicalis PE=2 SV=1 PF10266 Hereditary spastic paraplegia protein strumpellin -- -- -- -- GO:0071203 WASH complex -- -- Cluster-13067.0 BF_2 3.00 0.32 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13075.0 BF_2 3.00 0.53 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13078.0 BF_2 3.00 0.79 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13082.0 BF_2 12.00 1.38 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08119 Scorpion acidic alpha-KTx toxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-13083.0 BF_2 11.47 0.31 1844 386778929 AFJ23968.1 1413 1.7e-153 muscarinic acetylcholine receptor type B long variant [Tribolium castaneum] 751237972 XM_011174604.1 319 3.86836e-164 PREDICTED: Solenopsis invicta probable muscarinic acetylcholine receptor gar-1 (LOC105205262), mRNA K04134 CHRMN muscarinic acetylcholine receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04134 Q09388 505 1.4e-49 Probable muscarinic acetylcholine receptor gar-2 OS=Caenorhabditis elegans GN=gar-2 PE=2 SV=3 PF02175//PF00001 Serpentine type 7TM GPCR chemoreceptor Srb//7 transmembrane receptor (rhodopsin family) GO:0007606//GO:0007186//GO:0007165 sensory perception of chemical stimulus//G-protein coupled receptor signaling pathway//signal transduction GO:0004888//GO:0004930 transmembrane signaling receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-13087.0 BF_2 6.00 0.37 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13100.0 BF_2 2.00 0.31 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13102.0 BF_2 2.00 0.44 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13110.0 BF_2 4.00 0.38 732 646710809 KDR16227.1 978 1.9e-103 Spectrin beta chain [Zootermopsis nevadensis] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 813 1.0e-85 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF02601//PF06008//PF00435//PF07851 Exonuclease VII, large subunit//Laminin Domain I//Spectrin repeat//TMPIT-like protein GO:0007165//GO:0030334//GO:0030155//GO:0006308//GO:0045995 signal transduction//regulation of cell migration//regulation of cell adhesion//DNA catabolic process//regulation of embryonic development GO:0008855//GO:0005515//GO:0005102 exodeoxyribonuclease VII activity//protein binding//receptor binding GO:0016021//GO:0009318 integral component of membrane//exodeoxyribonuclease VII complex KOG0517 Beta-spectrin Cluster-13114.0 BF_2 9.00 0.46 1099 719774680 XP_010220376.1 493 4.9e-47 PREDICTED: neuron navigator 3 [Tinamus guttatus] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q8IVL0 480 6.4e-47 Neuron navigator 3 OS=Homo sapiens GN=NAV3 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-13121.0 BF_2 8.00 0.96 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13122.0 BF_2 1.00 0.52 365 642928192 XP_967439.2 163 3.0e-09 PREDICTED: uncharacterized protein LOC655784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13125.0 BF_2 4.00 0.36 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13126.0 BF_2 5.00 0.60 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13130.0 BF_2 2.00 0.32 546 170038798 XP_001847235.1 268 3.0e-21 conserved hypothetical protein [Culex quinquefasciatus]>gi|167882481|gb|EDS45864.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13140.0 BF_2 3.00 0.32 680 262401207 ACY66506.1 285 4.0e-23 ubiquitin associated protein 2-like protein [Scylla paramamosain] 262401206 FJ774785.1 200 1.95971e-98 Scylla paramamosain ubiquitin associated protein 2-like protein mRNA, partial cds -- -- -- -- Q14157 154 2.5e-09 Ubiquitin-associated protein 2-like OS=Homo sapiens GN=UBAP2L PE=1 SV=2 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-13142.0 BF_2 2.00 1.53 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10486//PF03999//PF01299//PF03839 Phosphoinositide 3-kinase gamma adapter protein p101 subunit//Microtubule associated protein (MAP65/ASE1 family)//Lysosome-associated membrane glycoprotein (Lamp)//Translocation protein Sec62 GO:0015031//GO:0000226//GO:0000910 protein transport//microtubule cytoskeleton organization//cytokinesis GO:0008565//GO:0008017//GO:0046935 protein transporter activity//microtubule binding//1-phosphatidylinositol-3-kinase regulator activity GO:0016020//GO:0005944//GO:0016021//GO:0045298 membrane//phosphatidylinositol 3-kinase complex, class IB//integral component of membrane//tubulin complex -- -- Cluster-13144.0 BF_2 9.64 0.49 1118 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13145.0 BF_2 5.00 0.43 771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13153.0 BF_2 4.00 0.99 455 241564918 XP_002401964.1 409 1.1e-37 ribosomal protein L40, putative [Ixodes scapularis]>gi|67084045|gb|AAY66957.1| ribosomal protein L40 [Ixodes scapularis]>gi|215501940|gb|EEC11434.1| ribosomal protein L40, putative [Ixodes scapularis] 270211316 GU179017.1 78 8.44958e-31 Aedes aegypti ubiquitin-L40 ribosomal fusion protein (UbL40) gene, complete cds K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P18101 376 3.0e-35 Ubiquitin-60S ribosomal protein L40 OS=Drosophila melanogaster GN=RpL40 PE=1 SV=2 PF01020//PF00240 Ribosomal L40e family//Ubiquitin family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-13159.0 BF_2 2.00 0.53 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13160.1 BF_2 2.00 0.73 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13167.0 BF_2 1.00 0.37 399 67084103 AAY66986.1 340 9.7e-30 F1F0-type ATP synthase subunit g [Ixodes scapularis] -- -- -- -- -- K02140 ATPeFG, ATP5L, ATP20 F-type H+-transporting ATPase subunit g http://www.genome.jp/dbget-bin/www_bget?ko:K02140 Q5RFH0 234 7.8e-19 ATP synthase subunit g, mitochondrial OS=Pongo abelii GN=ATP5L PE=3 SV=1 PF04718 Mitochondrial ATP synthase g subunit GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG4103 Mitochondrial F1F0-ATP synthase, subunit g/ATP20 Cluster-13169.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13175.0 BF_2 2.00 0.32 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13177.0 BF_2 3.00 0.46 557 -- -- -- -- -- 525346445 KC793917.1 86 3.73863e-35 Scylla paramamosain clone Scpa25 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13179.0 BF_2 14.00 0.51 1437 288779616 BAI70369.1 445 2.3e-41 eukaryotic initiation factor 4E binding protein [Marsupenaeus japonicus] -- -- -- -- -- K07205 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07205 Q60876 268 3.2e-22 Eukaryotic translation initiation factor 4E-binding protein 1 OS=Mus musculus GN=Eif4ebp1 PE=1 SV=3 PF05456 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) GO:0045947 negative regulation of translational initiation GO:0008190 eukaryotic initiation factor 4E binding -- -- -- -- Cluster-13185.0 BF_2 1.00 3.98 260 194246087 ACF35535.1 313 8.5e-27 ribosomal protein L38 [Dermacentor variabilis] -- -- -- -- -- K02923 RP-L38e, RPL38 large subunit ribosomal protein L38e http://www.genome.jp/dbget-bin/www_bget?ko:K02923 A6N9N3 312 4.6e-28 60S ribosomal protein L38 OS=Ornithodoros parkeri GN=RpL38 PE=3 SV=1 PF01781 Ribosomal L38e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3499 60S ribosomal protein L38 Cluster-13203.0 BF_2 10.00 0.40 1324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13205.0 BF_2 4.00 2.84 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13217.0 BF_2 5.00 0.95 507 241613226 XP_002407362.1 378 4.8e-34 Paxillin, putative [Ixodes scapularis]>gi|215502782|gb|EEC12276.1| Paxillin, putative [Ixodes scapularis] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q5R7I1 360 2.4e-33 Paxillin OS=Pongo abelii GN=PXN PE=2 SV=1 PF00412//PF06467//PF07967//PF07975 LIM domain//MYM-type Zinc finger with FCS sequence motif//C3HC zinc finger-like//TFIIH C1-like domain GO:0006281 DNA repair GO:0008270//GO:0043169 zinc ion binding//cation binding GO:0005634 nucleus KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-13219.0 BF_2 9.00 0.32 1475 817214031 XP_012283269.1 677 3.0e-68 PREDICTED: myophilin [Orussus abietinus] -- -- -- -- -- -- -- -- -- P14318 442 2.2e-42 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF05706//PF00307 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Calponin homology (CH) domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0004721 protein tyrosine phosphatase activity//protein binding//phosphoprotein phosphatase activity -- -- KOG2046 Calponin Cluster-13224.0 BF_2 1.00 1.37 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13224.1 BF_2 4.00 0.72 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13225.3 BF_2 5.00 0.35 887 443731814 ELU16785.1 338 3.7e-29 hypothetical protein CAPTEDRAFT_225175 [Capitella teleta] -- -- -- -- -- -- -- -- -- P26779 238 6.0e-19 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-13230.0 BF_2 1.00 1.74 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13231.0 BF_2 3.00 0.53 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13238.0 BF_2 5.00 0.53 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13242.0 BF_2 2.00 0.75 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-13243.1 BF_2 5.00 1.52 424 17549915 NP_509585.1 319 2.8e-27 TBB-4 [Caenorhabditis elegans]>gi|268576989|ref|XP_002643476.1| C. briggsae CBR-TBB-4 protein [Caenorhabditis briggsae]>gi|1174596|sp|P41937.1|TBB4_CAEEL RecName: Full=Tubulin beta-4 chain; AltName: Full=Beta-4-tubulin [Caenorhabditis elegans]>gi|3873688|emb|CAA86310.1| TBB-4 [Caenorhabditis elegans] 333411319 JF767013.1 163 4.38995e-78 Helicoverpa armigera beta-tubulin mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 319 1.2e-28 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 -- -- GO:0051258//GO:0007018//GO:0006184//GO:0007067//GO:0009792 protein polymerization//microtubule-based movement//obsolete GTP catabolic process//mitotic nuclear division//embryo development ending in birth or egg hatching GO:0003924//GO:0005198//GO:0005525 GTPase activity//structural molecule activity//GTP binding GO:0005737//GO:0005879 cytoplasm//axonemal microtubule KOG1375 Beta tubulin Cluster-13244.0 BF_2 4.00 0.51 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13247.0 BF_2 2.00 0.89 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13247.1 BF_2 5.00 0.51 701 751453875 XP_011181382.1 232 5.7e-17 PREDICTED: adult-specific rigid cuticular protein 15.5-like [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- P82119 179 3.3e-12 Cuticle protein 6 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-13255.1 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13265.0 BF_2 1.00 0.67 344 321467326 EFX78317.1 317 3.9e-27 GST-N-Metaxin-like protein [Daphnia pulex] -- -- -- -- -- -- -- -- -- F7E235 191 6.5e-14 Failed axon connections homolog OS=Xenopus tropicalis GN=faxc PE=3 SV=1 PF13417 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG4244 Failed axon connections (fax) protein/glutathione S-transferase-like protein Cluster-13286.0 BF_2 2.00 0.34 532 321458779 EFX69841.1 655 3.9e-66 hypothetical protein DAPPUDRAFT_300660 [Daphnia pulex] -- -- -- -- -- K00826 E2.6.1.42, ilvE branched-chain amino acid aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00826 A7SLW1 625 4.8e-64 Branched-chain-amino-acid aminotransferase OS=Nematostella vectensis GN=v1g246094 PE=3 SV=1 PF01063 Amino-transferase class IV GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0975 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily Cluster-13289.0 BF_2 2.00 0.50 454 76154943 AAX26334.2 542 4.2e-53 SJCHGC03868 protein [Schistosoma japonicum] -- -- -- -- -- K03065 PSMC3, RPT5 26S proteasome regulatory subunit T5 http://www.genome.jp/dbget-bin/www_bget?ko:K03065 O88685 528 7.2e-53 26S protease regulatory subunit 6A OS=Mus musculus GN=Psmc3 PE=1 SV=2 PF00004 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524 ATP binding -- -- KOG0652 26S proteasome regulatory complex, ATPase RPT5 Cluster-13292.0 BF_2 1.00 0.44 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13294.0 BF_2 2.00 0.60 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13298.0 BF_2 16.00 0.91 1023 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13309.0 BF_2 12.00 1.00 787 270007970 EFA04418.1 150 2.1e-07 hypothetical protein TcasGA2_TC014718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00797 N-acetyltransferase GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0016407 acetyltransferase activity -- -- -- -- Cluster-13311.0 BF_2 6.00 31.79 251 241781184 XP_002400257.1 246 4.8e-19 ribosomal protein L39, putative [Ixodes scapularis]>gi|215510701|gb|EEC20154.1| ribosomal protein L39, putative [Ixodes scapularis] 225708741 BT075793.1 55 2.66446e-18 Caligus rogercresseyi clone crog-evm-507-292 60S ribosomal protein L39 putative mRNA, complete cds K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 Q6F482 225 5.4e-18 60S ribosomal protein L39 OS=Plutella xylostella GN=RpL39 PE=3 SV=1 PF00832 Ribosomal L39 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0002 60s ribosomal protein L39 Cluster-13313.0 BF_2 2.00 0.44 475 260796973 XP_002593479.1 235 1.7e-17 hypothetical protein BRAFLDRAFT_206590 [Branchiostoma floridae]>gi|229278703|gb|EEN49490.1| hypothetical protein BRAFLDRAFT_206590, partial [Branchiostoma floridae] 768931000 XM_011607966.1 56 1.50203e-18 PREDICTED: Takifugu rubripes U2 snRNP-associated SURP domain containing (u2surp), transcript variant X4, mRNA K12842 SR140 U2-associated protein SR140 http://www.genome.jp/dbget-bin/www_bget?ko:K12842 O15042 228 4.6e-18 U2 snRNP-associated SURP motif-containing protein OS=Homo sapiens GN=U2SURP PE=1 SV=2 PF01805 Surp module GO:0006396 RNA processing GO:0000166//GO:0003723 nucleotide binding//RNA binding -- -- KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains Cluster-13315.0 BF_2 78.55 2.77 1475 242003361 XP_002422710.1 830 5.5e-86 Lipase 3 precursor, putative [Pediculus humanus corporis]>gi|212505532|gb|EEB09972.1| Lipase 3 precursor, putative [Pediculus humanus corporis] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 692 2.3e-71 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF01738//PF04083 Dienelactone hydrolase family//Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-13316.1 BF_2 6.00 0.36 989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13317.0 BF_2 3.00 0.59 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13317.1 BF_2 6.00 0.90 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13318.0 BF_2 9.00 1.24 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13319.0 BF_2 15.00 2.50 538 478251110 ENN71586.1 539 1.1e-52 hypothetical protein YQE_11686, partial [Dendroctonus ponderosae]>gi|546683195|gb|ERL93035.1| hypothetical protein D910_10337 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P80601 353 1.7e-32 Ribonuclease UK114 OS=Capra hircus GN=HRSP12 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2317 Putative translation initiation inhibitor UK114/IBM1 Cluster-13321.0 BF_2 4.00 0.32 813 321457968 EFX69044.1 905 6.0e-95 hypothetical protein DAPPUDRAFT_114061 [Daphnia pulex] 656985104 KF773747.1 217 8.3801e-108 Fenneropenaeus chinensis aspartate aminotransferase (GOT) mRNA, complete cds K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 842 5.0e-89 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-13323.0 BF_2 9.67 0.33 1528 766918539 XP_011498898.1 703 3.0e-71 PREDICTED: heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [Ceratosolen solmsi marchali] -- -- -- -- -- K13158 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 http://www.genome.jp/dbget-bin/www_bget?ko:K13158 P21522 682 3.4e-70 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF04828//PF16367//PF00076//PF03972//PF08777 Glutathione-dependent formaldehyde-activating enzyme//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//MmgE/PrpD family//RNA binding motif GO:0008152 metabolic process GO:0016829//GO:0003723//GO:0016846//GO:0003676 lyase activity//RNA binding//carbon-sulfur lyase activity//nucleic acid binding -- -- -- -- Cluster-13333.0 BF_2 2.00 0.79 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04604 Type-A lantibiotic GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-13336.0 BF_2 4.00 0.31 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-13339.0 BF_2 1.00 0.63 349 449273737 EMC83151.1 174 1.5e-10 Enterin neuropeptide, partial [Columba livia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13347.0 BF_2 2.00 0.49 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13352.0 BF_2 1.00 1.52 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13362.0 BF_2 2.00 0.70 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13363.0 BF_2 8.00 0.36 1229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13366.0 BF_2 6.00 0.32 1081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13375.0 BF_2 1.00 2.59 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13379.0 BF_2 1.00 1.05 316 -- -- -- -- -- 116310686 CR855207.1 293 1.71976e-150 Oryza sativa genomic DNA, chromosome 4, BAC clone: H0306B06, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13382.0 BF_2 13.91 0.56 1327 546674815 ERL86101.1 908 4.4e-95 hypothetical protein D910_03515 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0UYT5 156 2.9e-09 Major facilitator superfamily domain-containing protein 6-B OS=Danio rerio GN=mfsd6b PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-13383.0 BF_2 15.26 0.38 1948 241627626 XP_002408070.1 701 6.5e-71 RNA-binding protein musashi, putative [Ixodes scapularis]>gi|215501115|gb|EEC10609.1| RNA-binding protein musashi, putative [Ixodes scapularis] -- -- -- -- -- K13044 HNRNPABD heterogeneous nuclear ribonucleoprotein A/B/D http://www.genome.jp/dbget-bin/www_bget?ko:K13044 Q08473 508 6.5e-50 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:1901363//GO:0003723//GO:0097159 nucleic acid binding//heterocyclic compound binding//RNA binding//organic cyclic compound binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-13384.0 BF_2 8.00 3.56 379 -- -- -- -- -- 119710194 DQ490951.2 354 0 Zea mays subsp. mays genotype CMS-S mitochondrion, complete genome -- -- -- -- P08742 273 2.2e-23 Cytochrome c oxidase subunit 1 OS=Zea mays GN=COX1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-13394.0 BF_2 6.00 0.35 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13395.0 BF_2 3.00 1.42 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03229 Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process -- -- -- -- -- -- Cluster-13396.0 BF_2 8.00 0.35 1237 675366400 KFM59302.1 1065 2.6e-113 Inositol oxygenase, partial [Stegodyphus mimosarum] 884851338 XM_013153653.1 42 2.47425e-10 PREDICTED: Cavia porcellus myo-inositol oxygenase (Miox), mRNA K00469 MIOX inositol oxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00469 Q9UGB7 903 6.4e-96 Inositol oxygenase OS=Homo sapiens GN=MIOX PE=1 SV=1 PF05153 Myo-inositol oxygenase GO:0019310//GO:0055114 inositol catabolic process//oxidation-reduction process GO:0005506//GO:0050113 iron ion binding//inositol oxygenase activity GO:0005737 cytoplasm KOG1573 Aldehyde reductase Cluster-13410.0 BF_2 2.00 0.55 439 91091514 XP_969527.1 430 3.9e-40 PREDICTED: transmembrane protein 181 [Tribolium castaneum]>gi|642936877|ref|XP_008194310.1| PREDICTED: transmembrane protein 181 [Tribolium castaneum]>gi|270000929|gb|EEZ97376.1| hypothetical protein TcasGA2_TC011201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2C4 155 1.2e-09 Transmembrane protein 181 OS=Homo sapiens GN=TMEM181 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-13411.0 BF_2 1.00 0.46 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13413.0 BF_2 5.00 0.59 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13418.0 BF_2 2.00 0.35 523 324022911 ADY15480.1 144 6.8e-07 NADH dehydrogenase subunit 6 (mitochondrion) [Aurelia aurita] 589061032 KF765450.1 500 0 Prunus mume isolate BJFU1210120008 plastid, complete genome -- -- -- -- Q09WW5 711 5.0e-74 NAD(P)H-quinone oxidoreductase subunit 6, chloroplastic OS=Morus indica GN=ndhG PE=3 SV=1 PF00499 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 GO:0006814//GO:0006120//GO:0006744//GO:0015992//GO:0055114 sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//proton transport//oxidation-reduction process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-13424.1 BF_2 11.34 0.36 1605 562744994 AHB33470.1 470 3.3e-44 T-complex protein subunit gamma [Locusta migratoria] 195038286 XM_001990555.1 46 1.93131e-12 Drosophila grimshawi GH18159 (Dgri\GH18159), mRNA K09495 CCT3, TRIC5 T-complex protein 1 subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K09495 P50143 455 7.4e-44 T-complex protein 1 subunit gamma OS=Xenopus laevis GN=cct3 PE=2 SV=2 PF00118//PF02118 TCP-1/cpn60 chaperonin family//Srg family chemoreceptor GO:0007606//GO:0007165 sensory perception of chemical stimulus//signal transduction GO:0004888//GO:0005524 transmembrane signaling receptor activity//ATP binding GO:0016020 membrane KOG0364 Chaperonin complex component, TCP-1 gamma subunit (CCT3) Cluster-13434.0 BF_2 2.00 0.36 519 321469134 EFX80115.1 345 3.3e-30 hypothetical protein DAPPUDRAFT_304194 [Daphnia pulex] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P20432 227 6.6e-18 Glutathione S-transferase 1-1 OS=Drosophila melanogaster GN=GstD1 PE=1 SV=1 PF16519 Tetramerisation domain of TRPM GO:0051262 protein tetramerization -- -- -- -- -- -- Cluster-13454.0 BF_2 5.00 0.38 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13456.0 BF_2 3.00 0.55 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13462.0 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02724//PF02064//PF07781//PF16752//PF04006 CDC45-like protein//MAS20 protein import receptor//Reovirus minor core protein Mu-2//Tubulin-specific chaperone C N-terminal domain//Mpp10 protein GO:0006364//GO:0006605//GO:0006886//GO:0006270 rRNA processing//protein targeting//intracellular protein transport//DNA replication initiation GO:0015631//GO:0005198 tubulin binding//structural molecule activity GO:0005732//GO:0005742//GO:0034457//GO:0019028//GO:0005634//GO:0045298 small nucleolar ribonucleoprotein complex//mitochondrial outer membrane translocase complex//Mpp10 complex//viral capsid//nucleus//tubulin complex -- -- Cluster-13469.0 BF_2 7.00 0.38 1055 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13470.0 BF_2 55.00 1.73 1618 432863587 XP_004070140.1 501 8.4e-48 PREDICTED: GDP-D-glucose phosphorylase 1 [Oryzias latipes] 645241229 XM_008228760.1 660 0 PREDICTED: Prunus mume GDP-L-galactose phosphorylase 1 (LOC103326528), mRNA K15630 VTC2 GDP-D-glucose phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K15630 Q8RWE8 1650 2.0e-182 GDP-L-galactose phosphorylase 1 OS=Arabidopsis thaliana GN=VTC2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2720 Predicted hydrolase (HIT family) Cluster-13474.0 BF_2 4.00 0.42 682 411595986 AFW19996.1 600 1.2e-59 mitochondrial cytochrome c oxidase subunit Va [Litopenaeus vannamei] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 415 1.4e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-13476.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13483.0 BF_2 5.00 0.56 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13492.0 BF_2 5.00 0.88 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13497.0 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13500.0 BF_2 2.00 0.38 505 260804857 XP_002597304.1 508 4.0e-49 hypothetical protein BRAFLDRAFT_203247 [Branchiostoma floridae]>gi|229282567|gb|EEN53316.1| hypothetical protein BRAFLDRAFT_203247 [Branchiostoma floridae] 148230960 NM_001094813.1 92 1.55922e-38 Xenopus laevis TSR1, 20S rRNA accumulation, homolog (tsr1), mRNA >gnl|BL_ORD_ID|630648 Xenopus laevis hypothetical LOC495115, mRNA (cDNA clone MGC:83112 IMAGE:6317840), complete cds K14799 TSR1 pre-rRNA-processing protein TSR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14799 Q5XGY1 493 9.1e-49 Pre-rRNA-processing protein TSR1 homolog OS=Xenopus laevis GN=tsr1 PE=2 SV=1 -- -- GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1980 Uncharacterized conserved protein Cluster-13505.1 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13512.0 BF_2 5.00 0.39 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13513.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13513.1 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13523.0 BF_2 6.00 0.40 913 270004918 EFA01366.1 450 3.9e-42 hypothetical protein TcasGA2_TC010351 [Tribolium castaneum] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 Q17005 276 2.4e-23 Lysozyme c-1 OS=Anopheles gambiae GN=AGAP007347 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-13540.0 BF_2 12.00 0.90 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13543.0 BF_2 2.00 0.44 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13548.0 BF_2 1.00 0.45 377 338224500 AEI88123.1 570 2.0e-56 hypothetical protein [Scylla paramamosain] 338224499 HM217901.1 305 4.46145e-157 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-13552.0 BF_2 25.00 8.94 403 241564915 XP_002401963.1 339 1.3e-29 ribosomal protein S25, putative [Ixodes scapularis]>gi|215501939|gb|EEC11433.1| ribosomal protein S25, putative, partial [Ixodes scapularis] 262401431 FJ774898.1 190 4.06694e-93 Scylla paramamosain 40S ribosomal protein S25 mRNA, partial cds K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q962Q5 315 3.2e-28 40S ribosomal protein S25 OS=Spodoptera frugiperda GN=RpS25 PE=3 SV=1 PF01325//PF08220 Iron dependent repressor, N-terminal DNA binding domain//DeoR-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005622//GO:0005840 transcription factor complex//intracellular//ribosome KOG1767 40S ribosomal protein S25 Cluster-13558.0 BF_2 4.00 0.31 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13559.0 BF_2 2.00 0.36 517 861599025 KMQ83534.1 149 1.8e-07 hypothetical protein RF55_19752 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13563.0 BF_2 1.00 0.99 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13574.0 BF_2 29.00 1.10 1389 91082391 XP_969041.1 1141 4.5e-122 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|642922554|ref|XP_008193224.1| PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270007505|gb|EFA03953.1| hypothetical protein TcasGA2_TC014097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 492 3.3e-48 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-13576.0 BF_2 4.00 0.36 747 642074420 CDQ87733.1 592 1.1e-58 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- Q96DM1 343 3.4e-31 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01609 Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-13577.0 BF_2 19.00 0.89 1182 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13584.0 BF_2 4.00 0.61 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13589.0 BF_2 6.00 0.84 587 861635019 KMQ91440.1 137 4.9e-06 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13592.0 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13593.2 BF_2 23.84 0.59 1984 642911122 XP_008200589.1 2412 2.6e-269 PREDICTED: endoplasmic reticulum aminopeptidase 1-like isoform X4 [Tribolium castaneum] 462310582 APGK01047275.1 78 3.89997e-30 Dendroctonus ponderosae Seq01047285, whole genome shotgun sequence K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q10836 931 5.9e-99 Thyrotropin-releasing hormone-degrading ectoenzyme OS=Rattus norvegicus GN=Trhde PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-13605.0 BF_2 9.00 0.60 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13622.0 BF_2 2.00 0.33 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13624.0 BF_2 6.00 0.33 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13633.0 BF_2 5.00 0.42 781 642911859 XP_008200777.1 544 4.2e-53 PREDICTED: uncharacterized protein LOC103315005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13638.0 BF_2 3.00 0.77 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-13640.0 BF_2 20.00 1.61 806 -- -- -- -- -- 528540458 AP012528.1 796 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- -- -- -- -- PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane -- -- Cluster-13651.0 BF_2 3.00 0.76 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13656.0 BF_2 4.00 0.34 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13665.0 BF_2 7.00 0.49 889 675370960 KFM63862.1 626 1.5e-62 Myosin regulatory light chain 2, partial [Stegodyphus mimosarum] 241154891 XM_002407364.1 106 4.65841e-46 Ixodes scapularis myosin regulatory light chain, putative, mRNA K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 Q5RBA4 442 1.3e-42 Myosin regulatory light polypeptide 9 OS=Pongo abelii GN=MYL9 PE=2 SV=3 PF13499//PF13405//PF13833//PF00036//PF08336//PF00804//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Syntaxin//EF hand GO:0006525//GO:0018401//GO:0006560//GO:0055114 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//proline metabolic process//oxidation-reduction process GO:0004656//GO:0016702//GO:0005509 procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//calcium ion binding GO:0005783//GO:0016020 endoplasmic reticulum//membrane KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-13670.0 BF_2 1.00 1.59 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13677.0 BF_2 3.00 0.39 605 241735383 XP_002404909.1 278 2.3e-22 prefoldin, putative [Ixodes scapularis]>gi|215505594|gb|EEC15088.1| prefoldin, putative [Ixodes scapularis] -- -- -- -- -- K04798 pfdB, PFDN6 prefoldin beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04798 O15212 251 1.3e-20 Prefoldin subunit 6 OS=Homo sapiens GN=PFDN6 PE=1 SV=1 PF01442//PF01920//PF15556//PF02346//PF01956 Apolipoprotein A1/A4/E domain//Prefoldin subunit//ZW10 interactor//Chordopoxvirus multifunctional envelope protein A27//Integral membrane protein DUF106 GO:0007093//GO:0042157//GO:0006457//GO:0006869//GO:0019064 mitotic cell cycle checkpoint//lipoprotein metabolic process//protein folding//lipid transport//fusion of virus membrane with host plasma membrane GO:0051082//GO:0008289 unfolded protein binding//lipid binding GO:0005576//GO:0000776//GO:0016020//GO:0016272//GO:0019031 extracellular region//kinetochore//membrane//prefoldin complex//viral envelope KOG3478 Prefoldin subunit 6, KE2 family Cluster-13680.0 BF_2 4.00 0.43 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13685.1 BF_2 9.00 0.94 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-13686.0 BF_2 4.00 1.63 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13687.0 BF_2 5.00 0.31 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13713.0 BF_2 2.00 0.36 522 836705190 XP_012787495.1 878 5.3e-92 PREDICTED: interleukin enhancer-binding factor 2 [Sorex araneus] 649100945 KJ891471.1 522 0 Synthetic construct Homo sapiens clone ccsbBroadEn_00865 ILF2 gene, encodes complete protein K13089 ILF2 interleukin enhancer-binding factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13089 Q12905 878 2.2e-93 Interleukin enhancer-binding factor 2 OS=Homo sapiens GN=ILF2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3793 Transcription factor NFAT, subunit NF45 Cluster-13717.1 BF_2 4.00 0.61 562 255045899 ACU00106.1 714 5.9e-73 troponin-C isoform 6 [Homarus americanus] 298106305 HM448422.1 51 1.07954e-15 Homarus americanus troponin C isoform 3 mRNA, complete cds -- -- -- -- P15159 429 2.7e-41 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF00036//PF13833//PF13405//PF13499//PF03352//PF13202//PF12763 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Methyladenine glycosylase//EF hand//Cytoskeletal-regulatory complex EF hand GO:0006284 base-excision repair GO:0005509//GO:0008725//GO:0005515 calcium ion binding//DNA-3-methyladenine glycosylase activity//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-13718.1 BF_2 2.00 1.26 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13732.0 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13742.0 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13744.0 BF_2 8.00 0.37 1185 375157305 ACY66494.3 1434 4.0e-156 serine protease [Scylla paramamosain] 375081799 FJ774773.2 1089 0 Scylla paramamosain serine protease mRNA, complete cds -- -- -- -- Q8MQS8 213 6.3e-16 Venom serine protease 34 OS=Apis mellifera PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-13752.0 BF_2 28.00 0.47 2776 675367441 KFM60343.1 2153 4.0e-239 Polyadenylate-binding protein 1, partial [Stegodyphus mimosarum] 768921143 XM_003965840.2 220 6.33139e-109 PREDICTED: Takifugu rubripes poly(A) binding protein, cytoplasmic 1 (pabpc1), mRNA K13126 PABPC polyadenylate-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13126 P20965 1885 2.0e-209 Polyadenylate-binding protein 1-A OS=Xenopus laevis GN=pabpc1-a PE=1 SV=3 PF04815//PF08777//PF09377//PF00658//PF16367//PF00076 Sec23/Sec24 helical domain//RNA binding motif//SBDS protein C-terminal domain//Poly-adenylate binding protein, unique domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006888//GO:0006886//GO:0042254 ER to Golgi vesicle-mediated transport//intracellular protein transport//ribosome biogenesis GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0030127 COPII vesicle coat KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-13763.0 BF_2 19.00 1.43 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13776.0 BF_2 2.00 0.32 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13777.0 BF_2 2.00 0.46 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13780.0 BF_2 6.00 0.63 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13781.0 BF_2 3.00 0.49 544 826419751 XP_012524774.1 665 2.7e-67 PREDICTED: serine hydroxymethyltransferase, cytosolic [Monomorium pharaonis]>gi|826419753|ref|XP_012524775.1| PREDICTED: serine hydroxymethyltransferase, cytosolic [Monomorium pharaonis] -- -- -- -- -- K00600 glyA, SHMT glycine hydroxymethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00600 P50431 625 4.9e-64 Serine hydroxymethyltransferase, cytosolic OS=Mus musculus GN=Shmt1 PE=1 SV=3 PF00464 Serine hydroxymethyltransferase -- -- GO:0016740 transferase activity -- -- KOG2467 Glycine/serine hydroxymethyltransferase Cluster-13788.0 BF_2 4.00 0.31 826 759051578 XP_011334903.1 703 1.6e-71 PREDICTED: anoctamin-8 isoform X5 [Cerapachys biroi] 241616514 XM_002407927.1 152 1.15808e-71 Ixodes scapularis transmembrane protein 16K, putative, mRNA K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 552 2.2e-55 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2513 Protein required for meiotic chromosome segregation Cluster-13792.0 BF_2 3.00 0.34 654 241853693 XP_002415923.1 708 3.4e-72 eukaryotic translation initiation factor, putative [Ixodes scapularis]>gi|215510137|gb|EEC19590.1| eukaryotic translation initiation factor, putative [Ixodes scapularis] 805758681 XM_012294293.1 80 9.59365e-32 PREDICTED: Megachile rotundata eukaryotic translation initiation factor 5 (LOC100880103), transcript variant X3, mRNA K03262 EIF5 translation initiation factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03262 P59325 619 2.9e-63 Eukaryotic translation initiation factor 5 OS=Mus musculus GN=Eif5 PE=1 SV=1 PF01873 Domain found in IF2B/IF5 GO:0006446//GO:0016070//GO:0006413 regulation of translational initiation//RNA metabolic process//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG2767 Translation initiation factor 5 (eIF-5) Cluster-13794.0 BF_2 2.00 0.50 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13795.1 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03785 Peptidase family C25, C terminal ig-like domain GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-13801.0 BF_2 4.00 0.36 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-13803.0 BF_2 20.00 0.33 2814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13805.0 BF_2 7.00 1.00 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13806.0 BF_2 3.00 0.33 668 119594653 EAW74247.1 951 2.3e-100 hCG2016877, isoform CRA_c [Homo sapiens] 332309153 NM_012094.4 668 0 Homo sapiens peroxiredoxin 5 (PRDX5), transcript variant 1, mRNA K11187 PRDX5 peroxiredoxin 5, atypical 2-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11187 P30044 940 1.8e-100 Peroxiredoxin-5, mitochondrial OS=Homo sapiens GN=PRDX5 PE=1 SV=4 PF00578//PF08534 AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0016491//GO:0016209 oxidoreductase activity//antioxidant activity -- -- KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin Cluster-13807.0 BF_2 1.00 0.38 397 646700138 KDR10430.1 319 2.6e-27 Protein lunapark [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q1KKT4 309 1.6e-27 Protein lunapark-A OS=Takifugu rubripes GN=lnpa PE=3 SV=1 PF02675 S-adenosylmethionine decarboxylase GO:0006560//GO:0008295//GO:0006525 proline metabolic process//spermidine biosynthetic process//arginine metabolic process GO:0004014 adenosylmethionine decarboxylase activity -- -- KOG2846 Predicted membrane protein Cluster-13810.0 BF_2 4.00 0.66 539 646705747 KDR13306.1 654 5.1e-66 Aldehyde dehydrogenase family 3 member B1, partial [Zootermopsis nevadensis] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11883 528 8.6e-53 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Rattus norvegicus GN=Aldh3a1 PE=1 SV=3 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-13810.1 BF_2 1.00 0.41 388 391345366 XP_003746960.1 170 4.8e-10 PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Metaseiulus occidentalis] -- -- -- -- -- K00129 E1.2.1.5 aldehyde dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00129 Q1JPA0 142 3.5e-08 Aldehyde dehydrogenase family 3 member B1 OS=Bos taurus GN=ALDH3B1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2456 Aldehyde dehydrogenase Cluster-13813.0 BF_2 8.65 0.50 1005 827563622 XP_012552354.1 249 8.7e-19 PREDICTED: uncharacterized protein LOC105842693 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13814.0 BF_2 3.00 0.33 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13822.0 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13828.0 BF_2 2.00 0.87 381 407853728 EKG06599.1 419 6.4e-39 glucose-regulated protein 78, putative [Trypanosoma cruzi] 631376673 XM_007924526.1 212 2.25378e-105 Pseudocercospora fijiensis CIRAD86 hypothetical protein mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q00043 464 1.6e-45 Heat shock 70 kDa protein OS=Ajellomyces capsulatus GN=HSP70 PE=3 SV=1 PF06455 NADH dehydrogenase subunit 5 C-terminus GO:0006744//GO:0006120//GO:0006814//GO:0042773//GO:0055114//GO:0015992 ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//ATP synthesis coupled electron transport//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-13844.2 BF_2 5.00 0.33 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726//PF07464//PF03480//PF00210//PF00430//PF01442//PF03586//PF01297 Transmembrane protein//Apolipophorin-III precursor (apoLp-III)//Bacterial extracellular solute-binding protein, family 7//Ferritin-like domain//ATP synthase B/B' CF(0)//Apolipoprotein A1/A4/E domain//Herpesvirus UL36 tegument protein//Zinc-uptake complex component A periplasmic GO:0042157//GO:0030001//GO:0006869//GO:0006508//GO:0015986//GO:0039693//GO:0006879//GO:0006810//GO:0015992 lipoprotein metabolic process//metal ion transport//lipid transport//proteolysis//ATP synthesis coupled proton transport//viral DNA genome replication//cellular iron ion homeostasis//transport//proton transport GO:0008289//GO:0046872//GO:0015078//GO:0008199//GO:0019784 lipid binding//metal ion binding//hydrogen ion transmembrane transporter activity//ferric iron binding//NEDD8-specific protease activity GO:0030288//GO:0005576//GO:0016021//GO:0045263 outer membrane-bounded periplasmic space//extracellular region//integral component of membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-13849.1 BF_2 6.00 0.38 950 755942011 XP_011298639.1 310 7.0e-26 PREDICTED: homeobox protein TGIF2-like isoform X2 [Fopius arisanus] -- -- -- -- -- K19554 TGIF2L, TGIFL homeobox protein TGIF2L http://www.genome.jp/dbget-bin/www_bget?ko:K19554 Q8MIB8 201 1.2e-14 Homeobox protein TGIF2LX OS=Pongo pygmaeus GN=TGIF2LX PE=2 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-13851.1 BF_2 31.00 2.21 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13856.0 BF_2 7.00 0.69 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13862.0 BF_2 2.00 0.66 413 460027843 AFJ11397.2 512 1.1e-49 prostaglandin F synthase [Penaeus monodon] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15121 351 2.2e-32 Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-13864.0 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13869.0 BF_2 5.00 0.88 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13877.0 BF_2 1.00 0.35 406 646721331 KDR22745.1 292 3.6e-24 Roundabout-like protein 1 [Zootermopsis nevadensis] -- -- -- -- -- K06754 ROBO2 roundabout, axon guidance receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06754 Q9HCK4 243 7.2e-20 Roundabout homolog 2 OS=Homo sapiens GN=ROBO2 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG4222 Axon guidance receptor Dscam Cluster-13878.0 BF_2 6.00 0.37 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13889.0 BF_2 4.00 1.18 428 391335054 XP_003741912.1 522 8.2e-51 PREDICTED: 40S ribosomal protein S26-like [Metaseiulus occidentalis] -- -- -- -- -- K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P62856 477 5.6e-47 40S ribosomal protein S26 OS=Rattus norvegicus GN=Rps26 PE=3 SV=3 PF01283 Ribosomal protein S26e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-13890.0 BF_2 10.00 0.37 1427 642914631 XP_008190292.1 479 2.7e-45 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0003676//GO:0016787 metal ion binding//nucleic acid binding//hydrolase activity -- -- -- -- Cluster-13893.0 BF_2 4.00 2.09 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13897.0 BF_2 4.00 1.19 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04579 Keratin, high-sulphur matrix protein -- -- GO:0005198 structural molecule activity GO:0045095 keratin filament -- -- Cluster-13897.1 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13903.0 BF_2 2.00 0.50 455 125811343 XP_001361845.1 451 1.5e-42 GA18359 [Drosophila pseudoobscura pseudoobscura]>gi|54637021|gb|EAL26424.1| GA18359 [Drosophila pseudoobscura pseudoobscura] -- -- -- -- -- K02130 ATPeF0F, ATP5J2 F-type H+-transporting ATPase subunit f http://www.genome.jp/dbget-bin/www_bget?ko:K02130 Q9W141 441 8.8e-43 Putative ATP synthase subunit f, mitochondrial OS=Drosophila melanogaster GN=CG4692 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-13909.0 BF_2 1.00 0.52 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13910.0 BF_2 1.00 0.41 387 524871031 XP_005092292.1 149 1.3e-07 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Aplysia californica] -- -- -- -- -- -- -- -- -- P57093 137 1.3e-07 Phytanoyl-CoA dioxygenase, peroxisomal OS=Rattus norvegicus GN=Phyh PE=1 SV=2 PF04722 Ssu72-like protein GO:0006470//GO:0006397 protein dephosphorylation//mRNA processing GO:0004721 phosphoprotein phosphatase activity GO:0005634 nucleus -- -- Cluster-13911.0 BF_2 3.00 0.41 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13915.0 BF_2 2.00 0.60 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13921.0 BF_2 2.00 0.45 474 443683514 ELT87741.1 526 3.1e-51 hypothetical protein CAPTEDRAFT_162451 [Capitella teleta] -- -- -- -- -- K03462 NAMPT nicotinamide phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03462 Q80Z29 410 3.6e-39 Nicotinamide phosphoribosyltransferase OS=Rattus norvegicus GN=Nampt PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-13929.0 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1393.0 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13932.0 BF_2 7.00 0.80 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13937.0 BF_2 6.00 0.60 704 270004798 EFA01246.1 330 2.5e-28 serine protease H33 [Tribolium castaneum] -- -- -- -- -- K03992 MASP1 mannan-binding lectin serine protease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03992 P13582 238 4.7e-19 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-13938.0 BF_2 12.00 1.69 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13943.0 BF_2 3.00 0.35 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-13944.0 BF_2 6.00 3.77 349 328899629 AEB54643.1 495 9.0e-48 ribosomal protein L36 [Procambarus clarkii] 195469538 XM_002099659.1 75 2.94375e-29 Drosophila yakuba RpL36 (Dyak\RpL36), partial mRNA K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 Q5RAZ9 384 2.8e-36 60S ribosomal protein L36 OS=Pongo abelii GN=RPL36 PE=3 SV=3 PF01158 Ribosomal protein L36e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-13949.0 BF_2 3.00 0.37 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13951.0 BF_2 5.00 0.35 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13958.0 BF_2 5.00 3.36 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537//PF01097 Scorpion toxin-like domain//Arthropod defensin GO:0006810//GO:0006952 transport//defense response GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-13962.0 BF_2 14.00 2.02 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-13965.0 BF_2 3.00 28.08 235 241581367 XP_002403503.1 243 1.0e-18 fatty acid synthase, putative [Ixodes scapularis]>gi|215502217|gb|EEC11711.1| fatty acid synthase, putative [Ixodes scapularis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 211 2.1e-16 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- GO:0042967//GO:0008152//GO:0006633 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process GO:0016297//GO:0016491 acyl-[acyl-carrier-protein] hydrolase activity//oxidoreductase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-13966.1 BF_2 5.00 0.50 702 742408646 AJB28949.1 507 7.4e-49 c-Jun protein [Litopenaeus vannamei] -- -- -- -- -- K04448 JUN transcription factor AP-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04448 P05412 358 5.7e-33 Transcription factor AP-1 OS=Homo sapiens GN=JUN PE=1 SV=2 PF03131//PF04977//PF00170//PF07716//PF06005 bZIP Maf transcription factor//Septum formation initiator//bZIP transcription factor//Basic region leucine zipper//Protein of unknown function (DUF904) GO:0043093//GO:0000917//GO:0007049//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm KOG0837 Transcriptional activator of the JUN family Cluster-13979.0 BF_2 4.00 0.31 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01047 MarR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-13981.0 BF_2 4.00 0.67 536 241122582 XP_002403588.1 633 1.4e-63 ribosomal protein L21, putative [Ixodes scapularis]>gi|67084019|gb|AAY66944.1| ribosomal protein L21 [Ixodes scapularis]>gi|215493478|gb|EEC03119.1| ribosomal protein L21, putative [Ixodes scapularis] 62083338 AY961492.1 52 2.85371e-16 Lysiphlebus testaceipes ribosomal protein L21 (RpL21) mRNA, complete cds K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 O09167 543 1.5e-54 60S ribosomal protein L21 OS=Mus musculus GN=Rpl21 PE=2 SV=3 PF01157 Ribosomal protein L21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1732 60S ribosomal protein L21 Cluster-13987.0 BF_2 1.00 0.32 416 241998180 XP_002433733.1 219 1.1e-15 ubiquinol-cytochrome C reductase hinge protein, putative [Ixodes scapularis]>gi|215495492|gb|EEC05133.1| ubiquinol-cytochrome C reductase hinge protein, putative [Ixodes scapularis] 262401202 FJ774783.1 246 3.11915e-124 Scylla paramamosain mitochondrial ubiquinol-cytochrome c reductase complex 11 kDa protein mRNA, partial cds; nuclear gene for mitochondrial product K00416 QCR6, UQCRH ubiquinol-cytochrome c reductase subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00416 P07919 172 1.3e-11 Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens GN=UQCRH PE=1 SV=2 -- -- GO:0006122//GO:0006118//GO:0006119//GO:0015992 mitochondrial electron transport, ubiquinol to cytochrome c//obsolete electron transport//oxidative phosphorylation//proton transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-13991.0 BF_2 6.00 0.34 1018 646709983 KDR15622.1 614 4.2e-61 RNA-binding protein 10 [Zootermopsis nevadensis] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 Q99KG3 483 2.7e-47 RNA-binding protein 10 OS=Mus musculus GN=Rbm10 PE=1 SV=1 PF16622//PF07808//PF01585 zinc-finger C2H2-type//RED-like protein N-terminal region//G-patch domain -- -- GO:0003676//GO:0046872 nucleic acid binding//metal ion binding GO:0005634 nucleus KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-13994.0 BF_2 2.00 0.33 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14004.0 BF_2 2.00 0.32 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14009.0 BF_2 5.00 0.62 624 675384101 KFM76998.1 189 4.9e-12 Cytochrome b-c1 complex subunit 9, partial [Stegodyphus mimosarum] -- -- -- -- -- K00419 QCR9, UCRC ubiquinol-cytochrome c reductase subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K00419 P00130 176 6.5e-12 Cytochrome b-c1 complex subunit 9 OS=Bos taurus GN=UQCR10 PE=1 SV=3 PF15462//PF05365//PF15761 Bartter syndrome, infantile, with sensorineural deafness (Barttin)//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Immortalisation up-regulated protein GO:0006821//GO:0006122 chloride transport//mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005634//GO:0005743 mitochondrial respiratory chain complex III//nucleus//mitochondrial inner membrane -- -- Cluster-14017.0 BF_2 4.00 0.35 769 356651210 AET34922.1 557 1.3e-54 interferon-related developmental regulator 1 [Macrobrachium rosenbergii] -- -- -- -- -- -- -- -- -- Q12894 193 8.6e-14 Interferon-related developmental regulator 2 OS=Homo sapiens GN=IFRD2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2842 Interferon-related protein PC4 like Cluster-14022.0 BF_2 3.00 1.94 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14026.0 BF_2 1.00 0.52 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14035.0 BF_2 3.00 0.34 651 328900207 AEB54658.1 532 8.6e-52 H+ transporting ATP synthase O subunit [Procambarus clarkii] -- -- -- -- -- K02137 ATPeF0O, ATP5O, ATP5 F-type H+-transporting ATPase subunit O http://www.genome.jp/dbget-bin/www_bget?ko:K02137 Q24439 420 3.4e-40 ATP synthase subunit O, mitochondrial OS=Drosophila melanogaster GN=Oscp PE=2 SV=2 PF00213 ATP synthase delta (OSCP) subunit GO:0015986 ATP synthesis coupled proton transport GO:0046933 proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex KOG1662 Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 Cluster-14036.0 BF_2 3.00 0.81 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14037.0 BF_2 1.00 0.48 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-14047.0 BF_2 2.00 1.01 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14055.0 BF_2 2.00 0.77 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14065.2 BF_2 4.00 0.35 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14065.3 BF_2 13.00 0.64 1132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14069.0 BF_2 30.28 0.71 2079 115443584 YP_778603.1 2258 2.0e-251 photosystem II P680 chlorophyll A apoprotein [Bigelowiella natans]>gi|122221270|sp|Q06J24.1|PSBB_BIGNA RecName: Full=Photosystem II CP47 reaction center protein; AltName: Full=PSII 47 kDa protein; AltName: Full=Protein CP-47>gi|110810229|gb|ABG91435.1| photosystem II P680 chlorophyll A apoprotein [Bigelowiella natans] 761231856 KM881642.1 2079 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- Q0G9T6 2587 5.8e-291 Photosystem II CP47 reaction center protein OS=Daucus carota GN=psbB PE=3 SV=1 PF01405//PF00421 Photosystem II reaction centre T protein//Photosystem II protein GO:0015979//GO:0018298//GO:0009767//GO:0019684 photosynthesis//protein-chromophore linkage//photosynthetic electron transport chain//photosynthesis, light reaction GO:0016168 chlorophyll binding GO:0009521//GO:0016021//GO:0016020//GO:0009539//GO:0009523//GO:0009535 photosystem//integral component of membrane//membrane//photosystem II reaction center//photosystem II//chloroplast thylakoid membrane -- -- Cluster-14073.0 BF_2 8.00 0.43 1057 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14075.0 BF_2 1.00 1.19 309 340714447 XP_003395740.1 365 9.4e-33 PREDICTED: ubiquinone biosynthesis protein COQ7 homolog isoform X2 [Bombus terrestris] -- -- -- -- -- K06134 COQ7 ubiquinone biosynthesis monooxygenase Coq7 http://www.genome.jp/dbget-bin/www_bget?ko:K06134 Q63619 314 3.2e-28 5-demethoxyubiquinone hydroxylase, mitochondrial (Fragment) OS=Rattus norvegicus GN=Coq7 PE=2 SV=3 PF03232 Ubiquinone biosynthesis protein COQ7 GO:0055114//GO:0006744 oxidation-reduction process//ubiquinone biosynthetic process -- -- -- -- KOG4061 DMQ mono-oxygenase/Ubiquinone biosynthesis protein COQ7/CLK-1/CAT5 Cluster-14076.0 BF_2 21.21 2.92 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14079.0 BF_2 13.00 0.37 1763 675370169 KFM63071.1 251 9.0e-19 hypothetical protein X975_17163, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q5Y4U4 133 1.8e-06 U8-agatoxin-Ao1a OS=Agelena orientalis PE=2 SV=1 PF05039//PF02819 Agouti protein//Spider toxin GO:0006810//GO:0009755//GO:0009405 transport//hormone-mediated signaling pathway//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-14082.0 BF_2 4.00 0.41 697 171189511 ACB42236.1 510 3.3e-49 glutathione peroxidase [Metapenaeus ensis]>gi|171189513|gb|ACB42237.1| glutathione peroxidase [Metapenaeus ensis] -- -- -- -- -- K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 P30710 428 4.4e-41 Epididymal secretory glutathione peroxidase OS=Rattus norvegicus GN=Gpx5 PE=2 SV=1 PF00255 Glutathione peroxidase GO:0006804//GO:0055114//GO:0006979//GO:0006749 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress//glutathione metabolic process GO:0004602//GO:0004601 glutathione peroxidase activity//peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-14087.0 BF_2 2.00 0.31 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14101.0 BF_2 2.00 0.47 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14113.0 BF_2 4.00 0.84 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9LS40 167 5.6e-11 Protein ASPARTIC PROTEASE IN GUARD CELL 1 OS=Arabidopsis thaliana GN=ASPG1 PE=1 SV=1 PF00026 Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-14121.0 BF_2 5.00 0.39 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02285 Cytochrome oxidase c subunit VIII GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-14123.0 BF_2 4.00 0.52 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14126.0 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14130.0 BF_2 6.00 0.61 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14135.0 BF_2 5.00 0.40 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00747 ssDNA binding protein GO:0006260 DNA replication GO:0003697 single-stranded DNA binding GO:0042025 host cell nucleus -- -- Cluster-14136.0 BF_2 2.00 0.41 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14145.0 BF_2 2.00 0.35 528 817068399 XP_012256135.1 604 3.1e-60 PREDICTED: protein phosphatase PTC7 homolog [Athalia rosae] 657813161 XM_008335693.1 53 7.80794e-17 PREDICTED: Cynoglossus semilaevis PTC7 protein phosphatase homolog (S. cerevisiae) (pptc7), mRNA -- -- -- -- Q5U3N5 501 1.1e-49 Protein phosphatase PTC7 homolog OS=Danio rerio GN=pptc7 PE=2 SV=1 PF07228//PF00481 Stage II sporulation protein E (SpoIIE)//Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG1379 Serine/threonine protein phosphatase Cluster-14149.0 BF_2 4.00 0.46 654 -- -- -- -- -- 751473785 XM_011193961.1 35 9.93908e-07 PREDICTED: Bactrocera cucurbitae uncharacterized LOC105218398 (LOC105218398), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14153.0 BF_2 30.61 2.03 917 642935895 XP_008198218.1 627 1.2e-62 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270013255|gb|EFA09703.1| hypothetical protein TcasGA2_TC011836 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q7ZU92 262 1.0e-21 Poly(A)-specific ribonuclease PARN OS=Danio rerio GN=parn PE=1 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-14156.0 BF_2 13.00 0.51 1352 115443588 YP_778607.1 476 5.6e-45 30S ribosomal protein S2 [Bigelowiella natans]>gi|122233783|sp|Q06J20.1|RR2_BIGNA RecName: Full=30S ribosomal protein S2, chloroplastic (chloroplast) [Bigelowiella natans]>gi|110810233|gb|ABG91439.1| 30S ribosomal protein S2 [Bigelowiella natans] 761231856 KM881642.1 1337 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- A9L985 1006 8.0e-108 30S ribosomal protein S2, chloroplastic OS=Lemna minor GN=rps2 PE=3 SV=1 PF00119//PF00318 ATP synthase A chain//Ribosomal protein S2 GO:0015992//GO:0042254//GO:0015986//GO:0006412 proton transport//ribosome biogenesis//ATP synthesis coupled proton transport//translation GO:0003735//GO:0015078 structural constituent of ribosome//hydrogen ion transmembrane transporter activity GO:0005840//GO:0005622//GO:0044444//GO:0043229 ribosome//intracellular//cytoplasmic part//intracellular organelle KOG0832 Mitochondrial/chloroplast ribosomal protein S2 Cluster-14156.4 BF_2 2.00 0.37 516 -- -- -- -- -- 761231605 KM881639.1 516 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q6ENI2 907 9.3e-97 DNA-directed RNA polymerase subunit beta'' OS=Oryza nivara GN=rpoC2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14158.1 BF_2 14.03 0.92 925 332376334 AEE63307.1 858 1.9e-89 unknown [Dendroctonus ponderosae]>gi|478257148|gb|ENN77311.1| hypothetical protein YQE_06137, partial [Dendroctonus ponderosae]>gi|546681446|gb|ERL91543.1| hypothetical protein D910_08873 [Dendroctonus ponderosae] -- -- -- -- -- K02537 MAD2 mitotic spindle assembly checkpoint protein MAD2 http://www.genome.jp/dbget-bin/www_bget?ko:K02537 Q556Y9 494 1.3e-48 Mitotic spindle assembly checkpoint protein MAD2A OS=Dictyostelium discoideum GN=mad2l1-1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3285 Spindle assembly checkpoint protein Cluster-14162.0 BF_2 7.76 0.43 1034 765337696 XP_011493198.1 735 4.0e-75 AAEL003675-PB [Aedes aegypti]>gi|403182596|gb|EJY57498.1| AAEL003675-PB [Aedes aegypti] 333755412 HQ161710.1 77 7.19918e-30 Drosophila ficusphila strain 14025-0441.00 Rieske iron-sulfur protein (RFeSP) gene, partial cds K00411 UQCRFS1, RIP1, petA ubiquinol-cytochrome c reductase iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00411 Q69BJ7 694 9.3e-72 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Saimiri sciureus GN=UQCRFS1 PE=3 SV=1 PF09165//PF02921//PF00355 Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//Ubiquinol cytochrome reductase transmembrane region//Rieske [2Fe-2S] domain GO:0006118//GO:0055114//GO:0006119//GO:0015992 obsolete electron transport//oxidation-reduction process//oxidative phosphorylation//proton transport GO:0051537//GO:0008121//GO:0016491 2 iron, 2 sulfur cluster binding//ubiquinol-cytochrome-c reductase activity//oxidoreductase activity -- -- KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-14164.0 BF_2 4.00 0.62 559 158187872 ABW23225.1 607 1.5e-60 ribosomal protein rpl26 [Eurythoe complanata] 147769703 AM446700.2 35 8.41616e-07 Vitis vinifera contig VV78X252897.7, whole genome shotgun sequence K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61257 564 5.9e-57 60S ribosomal protein L26 OS=Bos taurus GN=RPL26 PE=2 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG3401 60S ribosomal protein L26 Cluster-14168.0 BF_2 6.00 1.36 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14181.0 BF_2 4.00 1.82 377 733916798 XP_010720481.1 392 8.6e-36 PREDICTED: polyubiquitin-B, partial [Meleagris gallopavo] 326525662 AK357664.1 179 4.92595e-87 Hordeum vulgare subsp. vulgare mRNA for predicted protein, complete cds, clone: NIASHv1058N10 K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CG55 387 1.3e-36 Polyubiquitin-B OS=Ovis aries GN=UBB PE=2 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-14194.0 BF_2 3.00 0.44 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14196.0 BF_2 4.00 0.62 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12549 Tyrosine hydroxylase N terminal GO:0055114//GO:0006570 oxidation-reduction process//tyrosine metabolic process GO:0004511 tyrosine 3-monooxygenase activity -- -- -- -- Cluster-14202.0 BF_2 22.00 0.92 1290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14202.1 BF_2 16.00 0.66 1309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14202.2 BF_2 5.00 0.76 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14208.0 BF_2 12.06 0.34 1774 91086047 XP_973605.1 1543 1.4e-168 PREDICTED: protein turtle homolog B [Tribolium castaneum] 642927616 XM_968512.2 282 1.37586e-143 PREDICTED: Tribolium castaneum protein turtle homolog B (LOC662415), mRNA -- -- -- -- O60500 195 1.2e-13 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-14210.0 BF_2 2.00 1.85 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14215.0 BF_2 5.00 0.33 921 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14232.0 BF_2 1.00 1.82 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14238.0 BF_2 3.00 0.40 603 307177231 EFN66426.1 280 1.3e-22 hypothetical protein EAG_01870, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14249.0 BF_2 10.00 0.37 1421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14249.1 BF_2 3.00 0.48 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14253.0 BF_2 1.00 2.81 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14266.0 BF_2 3.02 1.36 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14267.0 BF_2 12.00 0.48 1328 301500958 YP_003795423.1 1873 5.6e-207 photosystem I P700 chlorophyll a apoprotein A2 [Alveolata sp. CCMP3155]>gi|300069504|gb|ADJ66611.1| photosystem I P700 chlorophyll a apoprotein A2 (chloroplast) [Chromerida sp. RM11] 597569085 KF990036.1 1289 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q09X18 2396 5.2e-269 Photosystem I P700 chlorophyll a apoprotein A2 OS=Morus indica GN=psaB PE=3 SV=1 PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009507//GO:0016021//GO:0009522//GO:0009579 chloroplast//integral component of membrane//photosystem I//thylakoid -- -- Cluster-14276.0 BF_2 4.00 0.34 776 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14282.1 BF_2 8.03 0.35 1236 805767235 XP_012135536.1 715 9.9e-73 PREDICTED: RNA-binding protein squid isoform X8 [Megachile rotundata] 194741283 XM_001953084.1 173 3.72035e-83 Drosophila ananassae GF17370 (Dana\GF17370), mRNA K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 710 1.5e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076//PF02950//PF08777//PF11837//PF00335 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Conotoxin//RNA binding motif//Domain of unknown function (DUF3357)//Tetraspanin family GO:0009405//GO:0005982//GO:0006012//GO:0005985//GO:0006810 pathogenesis//starch metabolic process//galactose metabolic process//sucrose metabolic process//transport GO:0003676//GO:0004564//GO:0003723//GO:0004575//GO:0008200 nucleic acid binding//beta-fructofuranosidase activity//RNA binding//sucrose alpha-glucosidase activity//ion channel inhibitor activity GO:0005576//GO:0016021//GO:0017177 extracellular region//integral component of membrane//glucosidase II complex -- -- Cluster-14290.0 BF_2 12.00 0.55 1199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14292.0 BF_2 20.73 0.34 2803 478258061 ENN78199.1 2771 8.8e-311 hypothetical protein YQE_05351, partial [Dendroctonus ponderosae] 462344103 APGK01035160.1 71 4.30925e-26 Dendroctonus ponderosae Seq01035170, whole genome shotgun sequence K01590 hdc, HDC histidine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01590 Q05733 2063 4.5e-230 Histidine decarboxylase OS=Drosophila melanogaster GN=Hdc PE=2 SV=2 PF07359//PF00282//PF04604 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)//Pyridoxal-dependent decarboxylase conserved domain//Type-A lantibiotic GO:0019752//GO:0042742 carboxylic acid metabolic process//defense response to bacterium GO:0030170//GO:0016831 pyridoxal phosphate binding//carboxy-lyase activity GO:0005576 extracellular region KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-14297.0 BF_2 5.00 1.00 497 240978632 XP_002403001.1 474 3.5e-45 ribosomal protein S17, putative [Ixodes scapularis]>gi|215491265|gb|EEC00906.1| ribosomal protein S17, putative [Ixodes scapularis] -- -- -- -- -- K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 A5PK63 453 3.9e-44 40S ribosomal protein S17 OS=Bos taurus GN=RPS17 PE=2 SV=1 PF00833 Ribosomal S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0187 40S ribosomal protein S17 Cluster-14298.0 BF_2 6.00 0.64 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10723 Replication regulatory protein RepB GO:0006276 plasmid maintenance -- -- -- -- -- -- Cluster-14309.0 BF_2 25.00 0.88 1472 766931243 XP_011497794.1 215 1.1e-14 PREDICTED: proline-rich protein 4-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14310.0 BF_2 3.00 0.79 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14313.0 BF_2 3.00 0.41 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14313.3 BF_2 5.00 0.66 602 321459849 EFX70898.1 381 2.6e-34 troponin C [Daphnia pulex] 642936036 XM_968886.2 62 8.91426e-22 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA -- -- -- -- P06708 337 1.3e-30 Troponin C, isotype gamma OS=Astacus leptodactylus PE=1 SV=1 PF13202//PF00036//PF03874//PF12763//PF04277//PF13499//PF13405//PF13833 EF hand//EF hand//RNA polymerase Rpb4//Cytoskeletal-regulatory complex EF hand//Oxaloacetate decarboxylase, gamma chain//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0006525//GO:0006351//GO:0006560//GO:0006144//GO:0006090//GO:0006206//GO:0071436//GO:0006814 arginine metabolic process//transcription, DNA-templated//proline metabolic process//purine nucleobase metabolic process//pyruvate metabolic process//pyrimidine nucleobase metabolic process//sodium ion export//sodium ion transport GO:0003899//GO:0005515//GO:0008948//GO:0005509//GO:0015081 DNA-directed RNA polymerase activity//protein binding//oxaloacetate decarboxylase activity//calcium ion binding//sodium ion transmembrane transporter activity GO:0016020//GO:0005730 membrane//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-14317.0 BF_2 12.00 0.41 1497 270017042 EFA13488.1 981 1.7e-103 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 336 4.4e-30 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14317.1 BF_2 9.00 0.83 742 270017042 EFA13488.1 449 4.2e-42 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14318.0 BF_2 2.00 0.35 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14325.0 BF_2 2.00 0.36 518 675371070 KFM63972.1 276 3.3e-22 Neuron navigator 2, partial [Stegodyphus mimosarum] -- -- -- -- -- K16776 NAV1 neuron navigator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16776 Q80TN7 212 3.6e-16 Neuron navigator 3 OS=Mus musculus GN=Nav3 PE=1 SV=2 PF09726//PF01213//PF04767 Transmembrane protein//Adenylate cyclase associated (CAP) N terminal//DNA-binding 11 kDa phosphoprotein GO:0019082//GO:0007010 viral protein processing//cytoskeleton organization GO:0003677//GO:0003779 DNA binding//actin binding GO:0016021 integral component of membrane -- -- Cluster-14333.0 BF_2 10.28 0.33 1593 642933218 XP_008197312.1 945 2.7e-99 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 611 6.0e-62 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-14339.0 BF_2 4.00 0.68 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14340.0 BF_2 3.00 0.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14345.1 BF_2 14.00 1.30 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14348.0 BF_2 1.00 0.53 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14356.1 BF_2 3.00 0.53 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14359.0 BF_2 4.00 0.95 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14361.0 BF_2 2.00 2.98 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14362.0 BF_2 8.00 0.92 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14373.0 BF_2 1.00 0.32 418 4505357 NP_002480.1 442 1.5e-41 cytochrome c oxidase subunit NDUFA4 [Homo sapiens]>gi|120952247|ref|NP_001073393.1| cytochrome c oxidase subunit NDUFA4 [Pan troglodytes]>gi|397509251|ref|XP_003825042.1| PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 [Pan paniscus]>gi|2499333|sp|O00483.1|NDUA4_HUMAN RecName: Full=Cytochrome c oxidase subunit NDUFA4; AltName: Full=Complex I-MLRQ; Short=CI-MLRQ; AltName: Full=NADH-ubiquinone oxidoreductase MLRQ subunit>gi|115502280|sp|Q0MQ99.1|NDUA4_PANTR RecName: Full=Cytochrome c oxidase subunit NDUFA4 [Pan troglodytes]>gi|6456749|gb|AAF09253.1|AF201077_1 NADH:ubiquinone oxidoreductase MLRQ subunit [Homo sapiens]>gi|1946692|gb|AAB52726.1| NADH:ubiquinone oxidoreductase MLRQ subunit [Homo sapiens]>gi|47115173|emb|CAG28546.1| NDUFA4 [Homo sapiens]>gi|49456393|emb|CAG46517.1| NDUFA4 [Homo sapiens]>gi|51095053|gb|EAL24297.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa [Homo sapiens]>gi|60823909|gb|AAX36661.1| NADH dehydrogenase 1 alpha subcomplex 4 [synthetic construct]>gi|75516812|gb|AAI01795.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa [Homo sapiens]>gi|75517917|gb|AAI01797.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa [Homo sapiens]>gi|75867827|gb|AAI05296.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa [Homo sapiens]>gi|111662374|gb|ABH12244.1| mitochondrial complex I subunit NDUFA4 [Pan troglodytes]>gi|119614037|gb|EAW93631.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, isoform CRA_b [Homo sapiens]>gi|119614038|gb|EAW93632.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa, isoform CRA_b [Homo sapiens]>gi|649101668|gb|AIC49259.1| NDUFA4, partial [synthetic construct] 316659406 NM_002489.3 418 0 Homo sapiens NDUFA4, mitochondrial complex associated (NDUFA4), mRNA K03948 NDUFA4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03948 O00483 442 6.2e-43 Cytochrome c oxidase subunit NDUFA4 OS=Homo sapiens GN=NDUFA4 PE=1 SV=1 -- -- GO:0044281//GO:0006120//GO:0006123//GO:0015992//GO:0006744//GO:0006814 small molecule metabolic process//mitochondrial electron transport, NADH to ubiquinone//mitochondrial electron transport, cytochrome c to oxygen//proton transport//ubiquinone biosynthetic process//sodium ion transport GO:0008137//GO:0004129 NADH dehydrogenase (ubiquinone) activity//cytochrome-c oxidase activity GO:0045277//GO:0005747//GO:0005751 respiratory chain complex IV//mitochondrial respiratory chain complex I//mitochondrial respiratory chain complex IV -- -- Cluster-14380.0 BF_2 3.00 0.38 615 62088522 BAD92708.1 972 7.8e-103 ribosomal protein L12 variant [Homo sapiens] 324021718 NM_000976.3 615 0 Homo sapiens ribosomal protein L12 (RPL12), mRNA K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61284 849 5.8e-90 60S ribosomal protein L12 OS=Bos taurus GN=RPL12 PE=2 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-14389.0 BF_2 11.00 0.33 1683 642913594 XP_008201078.1 828 1.1e-85 PREDICTED: uncharacterized protein LOC103315080 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14394.0 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14398.0 BF_2 1.00 1.05 316 512926407 XP_004931078.1 240 3.0e-18 PREDICTED: tyrosine aminotransferase [Bombyx mori] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 P17735 196 1.6e-14 Tyrosine aminotransferase OS=Homo sapiens GN=TAT PE=1 SV=1 PF00155//PF00839 Aminotransferase class I and II//Cysteine rich repeat GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding GO:0016020 membrane KOG0259 Tyrosine aminotransferase Cluster-14398.1 BF_2 3.00 0.51 534 -- -- -- -- -- 525346467 KC793939.1 255 4.04202e-129 Scylla paramamosain clone Scpa47 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14399.0 BF_2 1.00 2.06 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-14408.0 BF_2 2.00 0.81 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14414.1 BF_2 10.00 0.51 1108 321473502 EFX84469.1 147 6.5e-07 hypothetical protein DAPPUDRAFT_314800 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14419.0 BF_2 8.90 2.60 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14443.0 BF_2 4.00 0.56 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14446.0 BF_2 8.92 0.40 1215 270012615 EFA09063.1 201 3.9e-13 hypothetical protein TcasGA2_TC006778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14448.0 BF_2 1.00 0.40 390 82795529 ABB91678.1 237 8.4e-18 calcified cuticle protein CP6.1 [Callinectes sapidus] 82795528 DQ288153.1 196 1.81281e-96 Callinectes sapidus calcified cuticle protein CP6.1 mRNA, complete cds -- -- -- -- P81589 167 4.5e-11 Cuticle protein CP575 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-14452.0 BF_2 3.00 0.68 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14454.0 BF_2 1.00 0.45 377 820837702 XP_012349958.1 355 1.7e-31 PREDICTED: RNA-binding protein 1-like isoform X2 [Apis florea] 685047507 LN596019.1 57 3.25025e-19 Cyprinus carpio genome assembly common carp genome ,scaffold 000001628 K12892 SFRS3 splicing factor, arginine/serine-rich 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12892 Q02427 332 3.2e-30 RNA-binding protein 1 OS=Drosophila melanogaster GN=Rbp1 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-14461.0 BF_2 2.00 0.39 499 91088317 XP_969858.1 259 3.0e-20 PREDICTED: regulator of microtubule dynamics protein 1 [Tribolium castaneum]>gi|270011794|gb|EFA08242.1| hypothetical protein TcasGA2_TC005870 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DCV4 198 1.5e-14 Regulator of microtubule dynamics protein 1 OS=Mus musculus GN=Rmdn1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14466.0 BF_2 14.00 0.58 1293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14466.1 BF_2 7.61 0.43 1029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14468.1 BF_2 44.00 5.40 628 339257046 XP_003370102.1 204 9.0e-14 conserved hypothetical protein [Trichinella spiralis]>gi|316956761|gb|EFV46916.1| conserved hypothetical protein [Trichinella spiralis] 254927417 GQ336996.1 401 0 Leucosporidium sp. AY30 18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 26S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14478.0 BF_2 7.00 0.40 1016 115443591 YP_778610.1 371 6.3e-33 RNA polymerase beta subunit [Bigelowiella natans]>gi|122227441|sp|Q06J17.1|RPOB_BIGNA RecName: Full=DNA-directed RNA polymerase subunit beta; AltName: Full=PEP; AltName: Full=Plastid-encoded RNA polymerase subunit beta; Short=RNA polymerase subunit beta (chloroplast) [Bigelowiella natans]>gi|110810236|gb|ABG91442.1| RNA polymerase beta subunit [Bigelowiella natans] 761231856 KM881642.1 871 0 Oryza longistaminata isolate 81953 chloroplast, complete genome K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 P0C505 1003 1.3e-107 DNA-directed RNA polymerase subunit beta' OS=Oryza sativa subsp. indica GN=rpoC1 PE=3 SV=1 PF04560//PF00562//PF04997 RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 6//RNA polymerase Rpb1, domain 1 GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0097159//GO:1901363//GO:0016779 DNA-directed RNA polymerase activity//DNA binding//organic cyclic compound binding//heterocyclic compound binding//nucleotidyltransferase activity GO:0009536//GO:0005730 plastid//nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-14487.0 BF_2 6.00 0.33 1039 12861068 BAB32114.1 931 7.5e-98 unnamed protein product [Mus musculus] 49472823 NM_005507.2 1039 0 Homo sapiens cofilin 1 (non-muscle) (CFL1), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P23528 835 4.2e-88 Cofilin-1 OS=Homo sapiens GN=CFL1 PE=1 SV=3 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular -- -- Cluster-14501.0 BF_2 13.00 0.56 1260 795160751 XP_011796612.1 1566 2.1e-171 PREDICTED: aldose reductase [Colobus angolensis palliatus] 24497579 NM_001628.2 1260 0 Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase) (AKR1B1), mRNA >gnl|BL_ORD_ID|2610619 Homo sapiens aldo-keto reductase family 1, member B1 (aldose reductase), mRNA (cDNA clone MGC:1804 IMAGE:3357652), complete cds K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15121 1599 1.3e-176 Aldose reductase OS=Homo sapiens GN=AKR1B1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-14502.0 BF_2 1.00 0.74 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08649 DASH complex subunit Dad1 GO:0030472 mitotic spindle organization in nucleus -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-14503.0 BF_2 16.00 0.51 1592 391326202 XP_003737609.1 1733 1.2e-190 PREDICTED: non-specific lipid-transfer protein-like [Metaseiulus occidentalis] -- -- -- -- -- K08764 SCP2, SCPX sterol carrier protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08764 O62742 1442 2.6e-158 Non-specific lipid-transfer protein OS=Oryctolagus cuniculus GN=SCP2 PE=1 SV=1 PF02803//PF00108//PF08545 Thiolase, C-terminal domain//Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0008152//GO:0006633//GO:0042967 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1406 Peroxisomal 3-ketoacyl-CoA-thiolase P-44/SCP2 Cluster-14504.0 BF_2 9.00 0.75 792 662186613 XP_008483033.1 190 4.8e-12 PREDICTED: uncharacterized protein LOC103519719 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P82120 145 3.3e-08 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-14505.1 BF_2 6.70 0.32 1159 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-14519.0 BF_2 5.00 0.60 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14527.0 BF_2 5.73 0.38 921 642913029 XP_008201358.1 338 3.8e-29 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum]>gi|270001848|gb|EEZ98295.1| hypothetical protein TcasGA2_TC000745 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EAK8 204 5.4e-15 DNA damage-regulated autophagy modulator protein 1 OS=Xenopus tropicalis GN=dram1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-14534.0 BF_2 3.00 0.61 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14536.0 BF_2 2.00 1.22 351 196000721 XP_002110228.1 243 1.5e-18 expressed hypothetical protein [Trichoplax adhaerens]>gi|190586179|gb|EDV26232.1| expressed hypothetical protein [Trichoplax adhaerens] 675416885 XM_008923475.1 42 6.54997e-11 PREDICTED: Manacus vitellinus granulin (GRN), mRNA -- -- -- -- P28799 220 2.9e-17 Granulins OS=Homo sapiens GN=GRN PE=1 SV=2 PF14984 CD24 protein GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-14538.1 BF_2 41.58 1.15 1802 642918650 XP_008191522.1 1749 1.8e-192 PREDICTED: histamine-gated chloride channel isoform X1 [Tribolium castaneum] 462305122 APGK01049251.1 114 3.43714e-50 Dendroctonus ponderosae Seq01049261, whole genome shotgun sequence K05195 GLRA3 glycine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K05195 Q91XP5 588 3.2e-59 Glycine receptor subunit alpha-3 OS=Mus musculus GN=Glra3 PE=2 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-14544.0 BF_2 1.00 0.34 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14546.0 BF_2 16.00 1.31 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14547.0 BF_2 113.00 12.58 663 642932878 XP_008197023.1 147 3.9e-07 PREDICTED: uncharacterized protein LOC103314040 [Tribolium castaneum]>gi|270012440|gb|EFA08888.1| hypothetical protein TcasGA2_TC006589 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14555.0 BF_2 7.00 0.70 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14557.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14558.0 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14576.0 BF_2 5.92 0.35 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14576.1 BF_2 7.00 0.66 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14592.0 BF_2 7.00 0.71 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14594.0 BF_2 5.00 0.63 617 732554603 AIZ72682.1 449 3.4e-42 c-type lysozyme 4 [Harmonia axyridis] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 Q17005 283 2.5e-24 Lysozyme c-1 OS=Anopheles gambiae GN=AGAP007347 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14598.0 BF_2 2.00 0.45 472 260819088 XP_002604869.1 584 5.8e-58 hypothetical protein BRAFLDRAFT_217157 [Branchiostoma floridae]>gi|229290198|gb|EEN60879.1| hypothetical protein BRAFLDRAFT_217157 [Branchiostoma floridae] 338224354 HM217819.1 174 3.78339e-84 Scylla paramamosain hsp40 subfamily a member 2 mRNA, partial cds K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 Q2HJ94 545 8.0e-55 DnaJ homolog subfamily A member 2 OS=Bos taurus GN=DNAJA2 PE=2 SV=1 PF01155//PF00684 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//DnaJ central domain GO:0006260//GO:0009408//GO:0006457//GO:0006464 DNA replication//response to heat//protein folding//cellular protein modification process GO:0046872//GO:0051082//GO:0016151//GO:0005524//GO:0031072 metal ion binding//unfolded protein binding//nickel cation binding//ATP binding//heat shock protein binding GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-14606.0 BF_2 16.00 0.60 1394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14607.0 BF_2 10.00 0.38 1382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14617.0 BF_2 2.00 1.65 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14619.0 BF_2 3.00 0.39 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14628.0 BF_2 2.00 0.45 474 657587483 XP_008298035.1 280 1.0e-22 PREDICTED: fibrocystin-L [Stegastes partitus] -- -- -- -- -- -- -- -- -- Q86WI1 185 4.5e-13 Fibrocystin-L OS=Homo sapiens GN=PKHD1L1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14643.0 BF_2 5.00 0.34 911 241710660 XP_002412058.1 404 8.4e-37 saposin, putative [Ixodes scapularis]>gi|215505119|gb|EEC14613.1| saposin, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- O13035 335 3.5e-30 Proactivator polypeptide OS=Gallus gallus GN=PSAP PE=1 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-14652.0 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14653.0 BF_2 5.00 0.41 800 675385589 KFM78486.1 312 3.4e-26 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial, partial [Stegodyphus mimosarum] -- -- -- -- -- K00236 SDHC, SDH3 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00236 P70097 256 4.4e-21 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Cricetulus griseus GN=SDHC PE=2 SV=1 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0449 Succinate dehydrogenase, cytochrome b subunit Cluster-14658.0 BF_2 3.00 0.63 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14663.0 BF_2 6.00 0.52 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14664.0 BF_2 2.00 0.77 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14669.0 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14673.0 BF_2 2.00 0.31 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14674.0 BF_2 11.00 4.25 394 297294711 XP_002804494.1 407 1.6e-37 PREDICTED: hypothetical protein LOC698789 [Macaca mulatta] 675780847 XM_003824939.2 394 0 PREDICTED: Pan paniscus ribosomal protein L41 (RPL41), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14679.0 BF_2 2.00 0.31 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14680.0 BF_2 6.00 0.36 984 662206595 XP_008476763.1 237 2.1e-17 PREDICTED: collagen alpha-5(IV) chain-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q9ZHC5 132 1.3e-06 DNA-binding protein HU homolog OS=Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155) GN=hup PE=3 SV=1 PF05927//PF08026//PF07267 Penaeidin//Bee antimicrobial peptide//Nucleopolyhedrovirus capsid protein P87 GO:0042381 hemolymph coagulation GO:0008061 chitin binding GO:0005737//GO:0019028//GO:0005576 cytoplasm//viral capsid//extracellular region -- -- Cluster-14687.0 BF_2 3.00 0.36 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14693.0 BF_2 4.00 0.57 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14694.0 BF_2 1.00 0.53 363 242010839 XP_002426166.1 331 9.7e-29 Early growth response protein, putative [Pediculus humanus corporis]>gi|212510213|gb|EEB13428.1| Early growth response protein, putative [Pediculus humanus corporis] 347968525 XM_312150.5 115 1.78587e-51 Anopheles gambiae str. PEST AGAP002773-PA (AgaP_AGAP002773) mRNA, complete cds K12497 EGR3 early growth response protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12497 P43300 199 8.1e-15 Early growth response protein 3 OS=Mus musculus GN=Egr3 PE=2 SV=2 PF13465 Zinc-finger double domain -- -- GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-14700.0 BF_2 5.00 0.50 707 443698513 ELT98489.1 665 3.5e-67 hypothetical protein CAPTEDRAFT_177664 [Capitella teleta] -- -- -- -- -- K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 Q5SVL6 588 1.2e-59 Rap1 GTPase-activating protein 2 OS=Mus musculus GN=Rap1gap2 PE=2 SV=1 PF02145 Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-14712.0 BF_2 3.00 0.42 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14713.0 BF_2 3.00 1.01 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14716.0 BF_2 9.00 0.60 915 684394821 XP_009171024.1 1272 1.9e-137 hypothetical protein T265_07282 [Opisthorchis viverrini]>gi|663049191|gb|KER25244.1| hypothetical protein T265_07282 [Opisthorchis viverrini] 158287871 XM_309765.4 339 1.43635e-175 Anopheles gambiae str. PEST AGAP010929-PA (AgaP_AGAP010929) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P68372 1255 7.3e-137 Tubulin beta-4B chain OS=Mus musculus GN=Tubb4b PE=1 SV=1 PF00091//PF04816 Tubulin/FtsZ family, GTPase domain//tRNA (adenine(22)-N(1))-methyltransferase GO:0008033//GO:0009451 tRNA processing//RNA modification GO:0003924//GO:0016429 GTPase activity//tRNA (adenine-N1-)-methyltransferase activity -- -- KOG1375 Beta tubulin Cluster-14718.0 BF_2 16.00 0.46 1749 821033957 XP_012353756.1 2236 6.0e-249 PREDICTED: alpha-enolase isoform X1 [Nomascus leucogenys] 346708295 AK378450.1 1749 0 Bombyx mori mRNA, clone: fmgV43K17 K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 P06733 2224 6.1e-249 Alpha-enolase OS=Homo sapiens GN=ENO1 PE=1 SV=2 PF00113//PF03952 Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain GO:0006096//GO:0009094//GO:0006094//GO:0006571//GO:0000162 glycolytic process//L-phenylalanine biosynthetic process//gluconeogenesis//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0004634//GO:0000287 phosphopyruvate hydratase activity//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-14730.0 BF_2 10.00 0.32 1591 391339532 XP_003744102.1 152 2.4e-07 PREDICTED: uncharacterized protein LOC100899560 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02601 Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-14731.0 BF_2 8.00 0.73 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14732.0 BF_2 4.00 0.46 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14736.0 BF_2 1.00 0.63 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14738.0 BF_2 8.00 0.75 731 119220845 ABL61513.1 256 9.8e-20 Der-p2-like allergen [Ixodes ricinus] -- -- -- -- -- -- -- -- -- O02380 201 9.6e-15 Mite group 2 allergen Tyr p 2 OS=Tyrophagus putrescentiae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14741.0 BF_2 9.00 4.76 363 544518890 XP_005592783.1 352 3.6e-31 PREDICTED: 60S ribosomal protein L39-like [Macaca fascicularis] 459642361 NM_001000.3 363 0 Homo sapiens ribosomal protein L39 (RPL39), mRNA K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 P62892 275 1.3e-23 60S ribosomal protein L39 OS=Mus musculus GN=Rpl39 PE=3 SV=2 PF00832 Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0002 60s ribosomal protein L39 Cluster-14744.0 BF_2 1.00 0.34 409 662186436 XP_008482145.1 520 1.3e-50 PREDICTED: uncharacterized protein LOC103518835 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14749.0 BF_2 23.53 0.94 1337 642937929 XP_008199135.1 1029 4.2e-109 PREDICTED: doublesex- and mab-3-related transcription factor A2-like [Tribolium castaneum]>gi|270015667|gb|EFA12115.1| hypothetical protein TcasGA2_TC002261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q801F8 244 1.8e-19 Doublesex- and mab-3-related transcription factor 1 OS=Oryzias latipes GN=dmrt1 PE=2 SV=1 PF00751 DM DNA binding domain GO:0007548//GO:0006355 sex differentiation//regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding GO:0005634 nucleus KOG3815 Transcription factor Doublesex Cluster-14750.0 BF_2 14.00 0.49 1485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14751.0 BF_2 2.00 0.49 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14754.0 BF_2 11.00 0.32 1709 645013054 XP_008216585.1 173 9.7e-10 PREDICTED: lipase 3-like [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-14759.0 BF_2 10.00 0.38 1402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14763.0 BF_2 3.00 2.88 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03213 Poxvirus P35 protein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-14767.0 BF_2 4.00 0.43 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02175 Serpentine type 7TM GPCR chemoreceptor Srb GO:0007606//GO:0007165 sensory perception of chemical stimulus//signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-14780.0 BF_2 3.00 0.37 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14786.0 BF_2 2.00 0.33 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14787.0 BF_2 9.00 0.44 1138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14790.0 BF_2 5.00 0.62 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14817.0 BF_2 49.00 1.66 1520 123406127 XP_001302740.1 1157 6.8e-124 AT5g28840/F7P1_20 [Trichomonas vaginalis G3]>gi|121884058|gb|EAX89810.1| AT5g28840/F7P1_20, putative [Trichomonas vaginalis G3] 694375810 XM_009366226.1 745 0 PREDICTED: Pyrus x bretschneideri GDP-mannose 3,5-epimerase 2 (LOC103954400), mRNA -- -- -- -- A3C4S4 1884 1.4e-209 GDP-mannose 3,5-epimerase 1 OS=Oryza sativa subsp. japonica GN=GME-1 PE=1 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0016616//GO:0005488 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//binding -- -- KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase Cluster-14824.0 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14826.0 BF_2 1.00 0.32 417 241729451 XP_002412260.1 135 6.0e-06 translation initiation factor 2C, putative [Ixodes scapularis]>gi|215505489|gb|EEC14983.1| translation initiation factor 2C, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14831.0 BF_2 5.00 0.38 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04825 N terminus of Rad21 / Rec8 like protein -- -- GO:0005515 protein binding -- -- -- -- Cluster-14832.0 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14838.0 BF_2 13.00 0.41 1607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14844.0 BF_2 5.00 2.16 382 767948590 XP_011514824.1 343 4.1e-30 PREDICTED: smoothened homolog isoform X1 [Homo sapiens] 300360510 NG_023340.1 382 0 Homo sapiens smoothened, frizzled class receptor (SMO), RefSeqGene on chromosome 7 K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 Q99835 343 1.7e-31 Smoothened homolog OS=Homo sapiens GN=SMO PE=1 SV=1 PF01534 Frizzled/Smoothened family membrane region GO:0007166 cell surface receptor signaling pathway -- -- GO:0016020 membrane -- -- Cluster-14857.1 BF_2 1.00 1.01 318 29134779 BAC66140.1 353 2.4e-31 projectin [Procambarus clarkii] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14858.1 BF_2 4.00 0.54 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14864.0 BF_2 5.00 0.33 914 646715184 KDR18888.1 599 2.1e-59 Proclotting enzyme [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- B5U2W0 501 2.0e-49 Venom serine protease Bi-VSP OS=Bombus ignitus PE=1 SV=1 PF00089//PF01829 Trypsin//Peptidase A6 family GO:0006508 proteolysis GO:0004190//GO:0004252 aspartic-type endopeptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-14865.0 BF_2 11.05 0.53 1164 642920923 XP_008192617.1 943 3.4e-99 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q5ZK84 583 7.8e-59 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-14867.0 BF_2 10.89 1.66 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF09090 Leucine rich repeat//MIF4G like GO:0016070 RNA metabolic process GO:0005515 protein binding -- -- -- -- Cluster-14876.0 BF_2 6.00 0.86 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14876.1 BF_2 6.00 1.37 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14877.0 BF_2 2.00 1.05 364 649572247 NP_001280528.1 345 2.3e-30 probable G-protein coupled receptor 52 [Tribolium castaneum]>gi|91088793|ref|XP_968380.1| PREDICTED: probable G-protein coupled receptor 52 [Tribolium castaneum]>gi|270012800|gb|EFA09248.1| hypothetical protein TcasGA2_TC006457 [Tribolium castaneum]>gi|485836770|tpg|DAA64512.1| TPA_inf: putative ecdysteroids/dopamine receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-14889.0 BF_2 1.00 1.29 305 646703159 KDR11975.1 184 9.1e-12 Up-regulated during skeletal muscle growth protein 5 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9JJW3 125 2.6e-06 Up-regulated during skeletal muscle growth protein 5 OS=Rattus norvegicus GN=Usmg5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-14899.0 BF_2 2.00 0.62 422 260833738 XP_002611869.1 408 1.3e-37 hypothetical protein BRAFLDRAFT_59218 [Branchiostoma floridae]>gi|322518338|sp|C3XVT5.1|LIS1_BRAFL RecName: Full=Lissencephaly-1 homolog [Branchiostoma floridae]>gi|229297241|gb|EEN67878.1| hypothetical protein BRAFLDRAFT_59218 [Branchiostoma floridae] -- -- -- -- -- K16794 PAFAH1B1, LIS1 platelet-activating factor acetylhydrolase IB subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16794 C3XVT5 408 5.5e-39 Lissencephaly-1 homolog OS=Branchiostoma floridae GN=BRAFLDRAFT_59218 PE=3 SV=1 PF00400 WD domain, G-beta repeat GO:0051301//GO:0007067//GO:0006810 cell division//mitotic nuclear division//transport GO:0005515 protein binding GO:0005815//GO:0005737//GO:0005874 microtubule organizing center//cytoplasm//microtubule KOG0292 Vesicle coat complex COPI, alpha subunit Cluster-14901.0 BF_2 16.30 1.01 961 685828771 CEF63693.1 166 3.5e-09 6-phosphofructokinase [Strongyloides ratti] -- -- -- -- -- K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 Q9TZL8 165 1.9e-10 ATP-dependent 6-phosphofructokinase 1 OS=Caenorhabditis elegans GN=pfk-1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-14902.0 BF_2 5.00 1.35 442 501298210 BAN21304.1 217 2.0e-15 unkown protein [Riptortus pedestris] -- -- -- -- -- K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P80432 146 1.4e-08 Cytochrome c oxidase subunit 7C, mitochondrial OS=Rattus norvegicus GN=Cox7c PE=1 SV=2 PF02935 Cytochrome c oxidase subunit VIIc GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-14915.0 BF_2 3.00 3.32 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04718 Mitochondrial ATP synthase g subunit GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-14920.0 BF_2 4.00 0.49 632 530660275 XP_005315177.1 318 5.5e-27 PREDICTED: uncharacterized protein LOC101933223 [Chrysemys picta bellii] 46518552 AC113334.2 611 0 Oryza sativa Japonica Group chromosome 5 clone OJ1123_F01, complete sequence -- -- -- -- -- -- -- -- PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-14921.0 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14923.0 BF_2 10.50 0.49 1191 642938802 XP_008199892.1 550 1.3e-53 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 421 4.8e-40 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-14930.0 BF_2 3.00 0.40 603 91081455 XP_973965.1 803 3.0e-83 PREDICTED: gamma-aminobutyric acid type B receptor subunit 2 [Tribolium castaneum]>gi|270005156|gb|EFA01604.1| hypothetical protein TcasGA2_TC007169 [Tribolium castaneum] -- -- -- -- -- K04615 GABBR gamma-aminobutyric acid type B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04615 O75899 340 6.1e-31 Gamma-aminobutyric acid type B receptor subunit 2 OS=Homo sapiens GN=GABBR2 PE=1 SV=1 PF00148 Nitrogenase component 1 type Oxidoreductase GO:0055114//GO:0007186//GO:0007216 oxidation-reduction process//G-protein coupled receptor signaling pathway//G-protein coupled glutamate receptor signaling pathway GO:0004965//GO:0016491 G-protein coupled GABA receptor activity//oxidoreductase activity GO:0016021 integral component of membrane KOG1055 GABA-B ion channel receptor subunit GABABR1 and related subunits, G-protein coupled receptor superfamily Cluster-14934.0 BF_2 2.00 0.32 546 -- -- -- -- -- 768311753 CP010981.1 543 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14947.0 BF_2 7.00 0.83 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14950.0 BF_2 7.00 1.84 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14957.0 BF_2 6.00 1.54 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14958.0 BF_2 1.00 0.52 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14961.0 BF_2 2.00 0.46 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14963.0 BF_2 15.61 0.48 1649 642924044 XP_008193983.1 876 2.8e-91 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q5R3Z8 625 1.5e-63 F-box/LRR-repeat protein 2 OS=Pongo abelii GN=FBXL2 PE=2 SV=1 PF00560//PF13516//PF13855//PF02126 Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat//Phosphotriesterase family GO:0009056 catabolic process GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG4341 F-box protein containing LRR Cluster-14964.0 BF_2 2.00 0.35 529 241614705 XP_002407617.1 379 3.9e-34 cytochrome P450, putative [Ixodes scapularis]>gi|215502842|gb|EEC12336.1| cytochrome P450, putative [Ixodes scapularis] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 A2RRT9 258 1.7e-21 Cytochrome P450 4V2 OS=Rattus norvegicus GN=Cyp4v2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016709//GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-14965.0 BF_2 0.80 0.65 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14977.2 BF_2 3.00 0.32 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14993.0 BF_2 2.00 0.44 478 -- -- -- -- -- 768311752 CP010980.1 460 0 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-14998.0 BF_2 6.00 0.94 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15004.0 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15009.0 BF_2 4.00 0.32 811 755954819 XP_011302900.1 221 1.2e-15 PREDICTED: NADH-ubiquinone oxidoreductase subunit 8 [Fopius arisanus] 761231605 KM881639.1 510 0 Oryza glaberrima isolate 101328 chloroplast, complete genome K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 Q0ZIW4 863 1.8e-91 NAD(P)H-quinone oxidoreductase subunit I, chloroplastic OS=Vitis vinifera GN=ndhI PE=3 SV=1 PF00146 NADH dehydrogenase GO:0055114 oxidation-reduction process -- -- GO:0016020 membrane -- -- Cluster-15009.1 BF_2 5.00 0.62 623 484759712 YP_007890019.1 184 1.9e-11 NADH dehydrogenase subunit 1 (mitochondrion) [Naegleria fowleri]>gi|400177460|gb|AFP72293.1| NADH dehydrogenase subunit 1 (mitochondrion) [Naegleria fowleri] 761231856 KM881642.1 623 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P12124 548 4.7e-55 NAD(P)H-quinone oxidoreductase subunit 1, chloroplastic OS=Oryza sativa subsp. japonica GN=ndhA PE=3 SV=2 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular -- -- Cluster-15012.0 BF_2 6.00 0.90 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15017.0 BF_2 3.00 1.20 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15023.0 BF_2 9.00 0.64 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15032.0 BF_2 6.00 0.67 664 321457848 EFX68926.1 157 2.7e-08 hypothetical protein DAPPUDRAFT_329602 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15035.0 BF_2 3.00 0.62 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15038.0 BF_2 10.00 0.75 845 115443544 YP_778563.1 642 2.0e-64 apocytochrome F [Bigelowiella natans]>gi|122233796|sp|Q06J64.1|CYF_BIGNA RecName: Full=Cytochrome f; Flags: Precursor (chloroplast) [Bigelowiella natans]>gi|110810189|gb|ABG91395.1| apocytochrome F [Bigelowiella natans] 761231856 KM881642.1 845 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C389 1111 3.4e-120 Cytochrome f OS=Oryza sativa subsp. japonica GN=petA PE=3 SV=1 PF01333 Apocytochrome F, C-terminal GO:0006118//GO:0044237//GO:0015979 obsolete electron transport//cellular metabolic process//photosynthesis GO:0005506//GO:0046872//GO:0020037//GO:0009055 iron ion binding//metal ion binding//heme binding//electron carrier activity GO:0009507//GO:0031361//GO:0016021//GO:0042651 chloroplast//integral component of thylakoid membrane//integral component of membrane//thylakoid membrane -- -- Cluster-15043.0 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15044.0 BF_2 6.00 0.60 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15047.0 BF_2 6.00 0.44 862 242024513 XP_002432672.1 876 1.5e-91 carboxypeptidase E precursor, putative [Pediculus humanus corporis]>gi|212518142|gb|EEB19934.1| carboxypeptidase E precursor, putative [Pediculus humanus corporis] 731254763 XM_010641770.1 68 6.00324e-25 PREDICTED: Fukomys damarensis carboxypeptidase Z (Cpz), transcript variant X1, mRNA K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P37892 638 2.4e-65 Carboxypeptidase E OS=Lophius americanus GN=cpe PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016788//GO:0008270//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//metallocarboxypeptidase activity -- -- KOG2649 Zinc carboxypeptidase Cluster-15047.1 BF_2 4.00 0.33 795 646699978 KDR10344.1 530 1.8e-51 Carboxypeptidase E [Zootermopsis nevadensis] -- -- -- -- -- K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P15087 386 3.7e-36 Carboxypeptidase E OS=Rattus norvegicus GN=Cpe PE=1 SV=1 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-15048.1 BF_2 2.00 0.50 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15049.0 BF_2 3.00 0.38 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15050.0 BF_2 9.00 1.26 585 -- -- -- -- -- 403311088 JX457150.1 585 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15055.0 BF_2 5.00 2.25 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15057.0 BF_2 1.00 1.43 300 328796230 AEB40304.1 241 2.2e-18 mitochondrial ATP synthase epsilon subunit precursor [Litopenaeus vannamei] -- -- -- -- -- K02135 ATPeF1E, ATP5E, ATP15 F-type H+-transporting ATPase subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K02135 Q96253 135 1.8e-07 ATP synthase subunit epsilon, mitochondrial OS=Arabidopsis thaliana GN=At1g51650 PE=1 SV=3 PF04627 Mitochondrial ATP synthase epsilon chain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG3495 Mitochondrial F1F0-ATP synthase, subunit epsilon/ATP15 Cluster-15059.0 BF_2 3.00 0.34 657 242010956 XP_002426223.1 414 4.2e-38 mitochondrial import inner membrane translocase subunit Tim23, putative [Pediculus humanus corporis]>gi|212510286|gb|EEB13485.1| mitochondrial import inner membrane translocase subunit Tim23, putative [Pediculus humanus corporis] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q5XH94 256 3.6e-21 Mitochondrial import inner membrane translocase subunit Tim23 OS=Xenopus tropicalis GN=timm23 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15066.0 BF_2 2.00 1.19 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15067.0 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15085.0 BF_2 3.00 0.44 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15086.1 BF_2 3.00 0.51 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15096.0 BF_2 4.00 0.53 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15107.0 BF_2 6.00 0.35 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00038//PF04513//PF08702//PF13851 Intermediate filament protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Growth-arrest specific micro-tubule binding GO:0030168//GO:0007165//GO:0051258//GO:0048870 platelet activation//signal transduction//protein polymerization//cell motility GO:0030674//GO:0005102//GO:0005198 protein binding, bridging//receptor binding//structural molecule activity GO:0005577//GO:0019028//GO:0031514//GO:0019031//GO:0005882 fibrinogen complex//viral capsid//motile cilium//viral envelope//intermediate filament -- -- Cluster-15109.0 BF_2 5.53 0.41 857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15112.0 BF_2 5.00 1.03 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15121.0 BF_2 4.00 0.57 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15125.0 BF_2 10.00 0.32 1590 642933218 XP_008197312.1 1230 2.4e-132 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12302 SLC17A6_7_8 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12302 O61369 758 5.4e-79 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF01004 Major Facilitator Superfamily//Flavivirus envelope glycoprotein M GO:0019058//GO:0055085 viral life cycle//transmembrane transport -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-15130.0 BF_2 5.00 0.64 614 -- -- -- -- -- 347816 L22270.1 107 8.78624e-47 IXORDBNF Ixodes dammini internal transcribed spacer 1 (ITS1), 5.8S ribosomal RNA, internal transcribed spacer 2 (ITS2) and 28S ribosomal RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15133.0 BF_2 4.00 0.67 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15135.0 BF_2 1.00 0.98 320 66392221 NP_001018164.1 156 1.7e-08 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C [Danio rerio]>gi|82228760|sp|Q502K3.1|ANR52_DANRE RecName: Full=Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C; Short=PP6-ARS-C; Short=Serine/threonine-protein phosphatase 6 regulatory subunit ARS-C [Danio rerio]>gi|63101294|gb|AAH95664.1| Zgc:112069 [Danio rerio]>gi|182890066|gb|AAI65234.1| Zgc:112069 protein [Danio rerio] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q502K3 156 6.9e-10 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Danio rerio GN=ankrd52 PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-15139.0 BF_2 2.00 0.37 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15141.0 BF_2 2.00 0.36 521 795018486 XP_011859227.1 221 8.0e-16 PREDICTED: uncharacterized protein LOC105556736 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-15150.1 BF_2 19.00 1.78 734 241833983 XP_002414973.1 222 8.6e-16 secreted salivary gland peptide, putative [Ixodes scapularis]>gi|215509185|gb|EEC18638.1| secreted salivary gland peptide, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15151.0 BF_2 7.00 0.56 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15151.1 BF_2 25.00 0.48 2456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15155.0 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15156.0 BF_2 6.00 0.36 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02723 Non-structural protein NS3/Small envelope protein E -- -- -- -- GO:0016020 membrane -- -- Cluster-15156.1 BF_2 3.00 0.43 580 391344579 XP_003746573.1 546 1.8e-53 PREDICTED: uncharacterized protein LOC100897996 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q9W0K7 458 1.2e-44 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15168.0 BF_2 3.00 0.32 675 560131505 CDJ88004.1 715 5.4e-73 AdoMet-dependent methyltransferase and Nicotinate phosphoribosyltransferase domain containing protein [Haemonchus contortus] -- -- -- -- -- K03462 NAMPT nicotinamide phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03462 Q99KQ4 635 4.2e-65 Nicotinamide phosphoribosyltransferase OS=Mus musculus GN=Nampt PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15173.0 BF_2 2.00 0.44 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15174.0 BF_2 1.00 0.52 364 241647516 XP_002411156.1 395 3.7e-36 eukaryotic translation initiation factor 4 gamma, putative [Ixodes scapularis]>gi|215503786|gb|EEC13280.1| eukaryotic translation initiation factor 4 gamma, putative, partial [Ixodes scapularis] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 Q95L46 331 4.0e-30 Eukaryotic translation initiation factor 4 gamma 2 OS=Bos taurus GN=EIF4G2 PE=2 SV=2 PF02854 MIF4G domain GO:0044260//GO:0044238 cellular macromolecule metabolic process//primary metabolic process GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-15175.0 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF07649 PHD-finger//C1-like domain GO:0055114 oxidation-reduction process GO:0047134//GO:0005515 protein-disulfide reductase activity//protein binding -- -- -- -- Cluster-15180.0 BF_2 3.00 0.82 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15189.0 BF_2 2.00 1.36 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15191.0 BF_2 5.00 0.40 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15202.0 BF_2 1.00 2.01 285 751211261 XP_011158361.1 152 4.3e-08 PREDICTED: uncharacterized protein LOC105194922 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15205.0 BF_2 5.00 0.34 896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15209.2 BF_2 6.00 0.47 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15218.0 BF_2 22.08 0.48 2216 356483015 CCE46010.1 2247 4.0e-250 putative DEAD-box ATP-dependent RNA helicase [Cancer pagurus] 356483014 HE608876.1 1532 0 Cancer pagurus mRNA for putative DEAD-box ATP-dependent RNA helicase (ddx gene) K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1781 1.8e-197 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF00270//PF00210//PF04851 DEAD/DEAH box helicase//Ferritin-like domain//Type III restriction enzyme, res subunit GO:0006879 cellular iron ion homeostasis GO:0003676//GO:0003677//GO:0016787//GO:0005524//GO:0008199 nucleic acid binding//DNA binding//hydrolase activity//ATP binding//ferric iron binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-15219.0 BF_2 2.00 0.90 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15221.0 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15224.2 BF_2 7.00 0.69 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15226.0 BF_2 2.00 1.88 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15228.1 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15232.0 BF_2 3.00 0.43 580 470436008 XP_004338838.1 663 5.0e-67 sulfate adenylyltransferase [Acanthamoeba castellanii str. Neff]>gi|440795708|gb|ELR16825.1| sulfate adenylyltransferase [Acanthamoeba castellanii str. Neff] 697073456 XM_009653110.1 365 0 Verticillium dahliae VdLs.17 sulfate adenylyltransferase partial mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 Q1EAF9 854 1.5e-90 Sulfate adenylyltransferase OS=Coccidioides immitis (strain RS) GN=MET3 PE=3 SV=1 PF01747 ATP-sulfurylase GO:0006790//GO:0006144 sulfur compound metabolic process//purine nucleobase metabolic process GO:0004781 sulfate adenylyltransferase (ATP) activity -- -- -- -- Cluster-15235.0 BF_2 4.00 1.24 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15240.0 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15241.0 BF_2 2.00 0.46 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15249.0 BF_2 3.00 0.43 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15255.0 BF_2 5.00 0.36 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15264.0 BF_2 12.00 1.36 657 484759911 YP_007890520.1 591 1.3e-58 NADH dehydrogenase subunit 2 (mitochondrion) [Andalucia godoyi]>gi|462269142|gb|AGH24014.1| NADH dehydrogenase subunit 2 (mitochondrion) [Andalucia godoyi] 2326761 Y14435.1 626 0 Triticum aestivum mitochondrial NADH dehydrogenase subunit 2 -- -- -- -- O05000 1003 8.7e-108 NADH-ubiquinone oxidoreductase chain 2 OS=Arabidopsis thaliana GN=ND2 PE=2 SV=2 PF02761 CBL proto-oncogene N-terminus, EF hand-like domain -- -- GO:0005509 calcium ion binding -- -- KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-15272.0 BF_2 1.00 0.66 345 -- -- -- -- -- 116317841 CR855024.1 324 1.10925e-167 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSIGBa0160I04, complete sequence -- -- -- -- -- -- -- -- PF13545 Crp-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-15274.0 BF_2 2.00 0.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15278.0 BF_2 4.00 0.33 800 646703364 KDR12091.1 304 2.9e-25 Hemicentin-1, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15283.0 BF_2 5.39 0.65 634 91076370 XP_967715.1 366 1.5e-32 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 P51159 301 2.1e-26 Ras-related protein Rab-27A OS=Homo sapiens GN=RAB27A PE=1 SV=3 PF08477//PF01926//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//ADP-ribosylation factor family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525 GTP binding -- -- KOG0081 GTPase Rab27, small G protein superfamily Cluster-15286.0 BF_2 4.00 0.72 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15308.0 BF_2 5.00 0.56 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15310.0 BF_2 3.00 0.36 639 642935758 XP_008198162.1 841 1.3e-87 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC663028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15312.0 BF_2 3.00 0.55 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15313.0 BF_2 6.00 0.36 978 762141224 XP_011453795.1 190 5.9e-12 PREDICTED: cysteine-rich motor neuron 1 protein-like [Crassostrea gigas] -- -- -- -- -- K08785 HTRA3 HtrA serine peptidase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08785 P83110 166 1.5e-10 Serine protease HTRA3 OS=Homo sapiens GN=HTRA3 PE=1 SV=2 PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-15315.0 BF_2 2.00 0.54 441 -- -- -- -- -- 116310127 CR855175.1 411 0 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSIGBa0122F23, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15320.0 BF_2 1.00 0.43 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15322.0 BF_2 2.00 0.40 498 383850086 XP_003700648.1 376 8.1e-34 PREDICTED: zinc finger protein Noc [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q24423 319 1.4e-28 Zinc finger protein Noc OS=Drosophila melanogaster GN=noc PE=1 SV=1 PF13008//PF00131//PF00096 Zinc-binding domain of Paramyxoviridae V protein//Metallothionein//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-15324.0 BF_2 2.00 0.35 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15330.0 BF_2 2.00 0.32 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15332.0 BF_2 3.00 0.52 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15334.0 BF_2 1.00 0.34 411 4502993 NP_001858.1 329 1.9e-28 cytochrome c oxidase subunit 7C, mitochondrial precursor [Homo sapiens]>gi|120952493|ref|NP_001073391.1| cytochrome c oxidase subunit 7C, mitochondrial precursor [Pan troglodytes]>gi|332224925|ref|XP_003261620.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Nomascus leucogenys]>gi|397504520|ref|XP_003822837.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Pan paniscus]>gi|426349408|ref|XP_004042297.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Gorilla gorilla gorilla]>gi|820976572|ref|XP_012360946.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial [Nomascus leucogenys]>gi|117127|sp|P15954.1|COX7C_HUMAN RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor>gi|38502871|sp|P60025.1|COX7C_PANTR RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor>gi|48427919|sp|P61638.1|COX7C_GORGO RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor>gi|48427920|sp|P61639.1|COX7C_PANPA RecName: Full=Cytochrome c oxidase subunit 7C, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide VIIc; Flags: Precursor [Pan paniscus]>gi|30155|emb|CAA34559.1| unnamed protein product [Homo sapiens]>gi|3859872|gb|AAC73062.1| cytochrome c oxidase subunit VIIc precursor [Homo sapiens]>gi|12654365|gb|AAH01005.1| Cytochrome c oxidase subunit VIIc [Homo sapiens]>gi|13960114|gb|AAH07498.1| Cytochrome c oxidase subunit VIIc [Homo sapiens]>gi|19773463|dbj|BAB86871.1| cytochrome oxidase subunit VIIc [Pan troglodytes]>gi|19773467|dbj|BAB86872.1| cytochrome oxidase subunit VIIc [Pan paniscus]>gi|19773471|dbj|BAB86873.1| cytochrome oxidase subunit VIIc [Gorilla gorilla]>gi|30583035|gb|AAP35762.1| cytochrome c oxidase subunit VIIc [Homo sapiens]>gi|60656107|gb|AAX32617.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|60656109|gb|AAX32618.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|119616329|gb|EAW95923.1| cytochrome c oxidase subunit VIIc, isoform CRA_b [Homo sapiens]>gi|123980904|gb|ABM82281.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|123995721|gb|ABM85462.1| cytochrome c oxidase subunit VIIc [synthetic construct]>gi|343960298|dbj|BAK64003.1| cytochrome c oxidase polypeptide VIIc, mitochondrial precursor [Pan troglodytes]>gi|649099321|gb|AIC48551.1| COX7C, partial [synthetic construct] 10439379 AK026505.1 411 0 Homo sapiens cDNA: FLJ22852 fis, clone KAT00780 K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P61638 329 7.7e-30 Cytochrome c oxidase subunit 7C, mitochondrial OS=Gorilla gorilla gorilla GN=COX7C PE=3 SV=1 PF02935 Cytochrome c oxidase subunit VIIc GO:0015992//GO:0006123//GO:0022904//GO:0044281 proton transport//mitochondrial electron transport, cytochrome c to oxygen//respiratory electron transport chain//small molecule metabolic process GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0016021//GO:0045277 mitochondrial inner membrane//integral component of membrane//respiratory chain complex IV -- -- Cluster-15341.0 BF_2 15.00 1.04 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15342.0 BF_2 7.00 0.55 816 391344452 XP_003746513.1 661 1.2e-66 PREDICTED: legumain-like [Metaseiulus occidentalis] -- -- -- -- -- K01369 LGMN legumain http://www.genome.jp/dbget-bin/www_bget?ko:K01369 Q99538 475 1.8e-46 Legumain OS=Homo sapiens GN=LGMN PE=1 SV=1 PF01650//PF04904 Peptidase C13 family//NAB conserved region 1 (NCD1) GO:0006508//GO:0045892 proteolysis//negative regulation of transcription, DNA-templated GO:0008233 peptidase activity GO:0005634 nucleus KOG1348 Asparaginyl peptidases Cluster-15345.0 BF_2 11.00 0.56 1114 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15347.0 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15351.0 BF_2 2.00 0.35 529 675377463 KFM70365.1 234 2.5e-17 Chondroitin proteoglycan 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P29030 148 9.7e-09 Endochitinase OS=Brugia malayi PE=1 SV=1 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-15362.0 BF_2 4.00 0.42 686 262401235 ACY66520.1 577 5.5e-57 hypothetical protein [Scylla paramamosain] 262401234 FJ774799.1 468 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15362.1 BF_2 7.00 0.54 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-15372.0 BF_2 2.00 0.42 488 321457352 EFX68440.1 630 2.8e-63 hypothetical protein DAPPUDRAFT_203278 [Daphnia pulex] -- -- -- -- -- K05034 SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA) member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05034 Q9VR07 549 2.8e-55 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-15375.0 BF_2 6.00 0.31 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15383.0 BF_2 4.00 0.73 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15385.0 BF_2 11.00 3.02 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-15387.0 BF_2 11.00 0.75 902 646715246 KDR18917.1 301 7.3e-25 Sestrin-like protein [Zootermopsis nevadensis] -- -- -- -- -- K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 Q9W1K5 236 1.0e-18 Sestrin homolog OS=Drosophila melanogaster GN=Sesn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3746 Uncharacterized conserved protein Cluster-15389.0 BF_2 25.00 1.16 1185 675380433 KFM73335.1 414 7.6e-38 40S ribosomal protein S27, partial [Stegodyphus mimosarum] 850303920 XM_004709855.2 91 1.36549e-37 PREDICTED: Echinops telfairi 40S ribosomal protein S27-like (LOC101643953), mRNA K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 P55833 444 1.0e-42 40S ribosomal protein S27 OS=Homarus americanus GN=RPS27 PE=3 SV=2 PF01667 Ribosomal protein S27 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1779 40s ribosomal protein S27 Cluster-15400.0 BF_2 6.00 0.31 1086 645004036 XP_008212795.1 493 4.8e-47 PREDICTED: GATA zinc finger domain-containing protein 10 isoform X3 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02854 MIF4G domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-15400.1 BF_2 2.00 2.34 310 815900527 XP_012236408.1 243 1.3e-18 PREDICTED: CBP80/20-dependent translation initiation factor isoform X2 [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00941 FAD binding domain in molybdopterin dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3942 MIF4G domain-containing protein Cluster-15413.0 BF_2 2.26 0.41 515 546683764 ERL93529.1 587 2.9e-58 hypothetical protein D910_10818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BDJ4 142 4.7e-08 Lipase member H OS=Oryctolagus cuniculus GN=LIPH PE=2 SV=1 PF00087//PF01383 Snake toxin//CpcD/allophycocyanin linker domain GO:0009405 pathogenesis -- -- GO:0005576//GO:0030089 extracellular region//phycobilisome -- -- Cluster-15414.0 BF_2 3.00 0.47 554 270011326 EFA07774.1 289 1.1e-23 hypothetical protein TcasGA2_TC005329 [Tribolium castaneum] -- -- -- -- -- K18172 CMC2 COX assembly mitochondrial protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18172 Q8K199 230 3.2e-18 COX assembly mitochondrial protein 2 homolog OS=Mus musculus GN=Cmc2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15415.0 BF_2 2.00 0.93 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15421.1 BF_2 1.00 0.32 417 -- -- -- -- -- 697066922 XM_009650353.1 414 0 Verticillium dahliae VdLs.17 glucose-repressible protein mRNA -- -- -- -- P22151 235 6.2e-19 Glucose-repressible gene protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=grg-1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15429.0 BF_2 5.00 1.13 472 283854615 ADB44903.1 250 3.1e-19 peritrophin [Macrobrachium nipponense] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-15442.0 BF_2 3.00 0.31 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15447.0 BF_2 6.00 0.65 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15457.0 BF_2 10.00 0.33 1552 91094593 XP_970561.1 141 4.5e-06 PREDICTED: cytochrome P450 6k1 [Tribolium castaneum]>gi|270016410|gb|EFA12856.1| cytochrome P450 345A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15459.0 BF_2 3.00 0.53 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15460.0 BF_2 8.00 0.53 915 546678389 ERL89019.1 1398 4.6e-152 hypothetical protein D910_06397 [Dendroctonus ponderosae] -- -- -- -- -- K10448 KLHL10 kelch-like protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K10448 Q6JEL3 731 4.2e-76 Kelch-like protein 10 OS=Rattus norvegicus GN=Klhl10 PE=2 SV=1 PF07646//PF00651//PF01344//PF01466 Kelch motif//BTB/POZ domain//Kelch motif//Skp1 family, dimerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-15460.1 BF_2 18.00 0.81 1212 546678389 ERL89019.1 1223 1.2e-131 hypothetical protein D910_06397 [Dendroctonus ponderosae] -- -- -- -- -- K10448 KLHL10 kelch-like protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K10448 Q6JEL2 788 1.4e-82 Kelch-like protein 10 OS=Homo sapiens GN=KLHL10 PE=1 SV=1 PF01344//PF07646 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-15461.0 BF_2 6.00 0.49 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15463.0 BF_2 9.00 0.33 1427 292807619 ADE42873.1 946 1.9e-99 ADP-ribosylation factor 1 [Marsupenaeus japonicus] 262400972 FJ774666.1 590 0 Scylla paramamosain ADP ribosylation factor mRNA, complete cds K07937 ARF1 ADP-ribosylation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07937 P61210 945 1.0e-100 ADP-ribosylation factor 1 OS=Locusta migratoria GN=ARF1 PE=2 SV=2 PF08477//PF01926//PF00503//PF01591//PF00025//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//6-phosphofructo-2-kinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0006000//GO:0006013//GO:0007264//GO:0007186//GO:0007165 fructose metabolic process//mannose metabolic process//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0003924//GO:0003873//GO:0031683//GO:0005524 signal transducer activity//guanyl nucleotide binding//GTP binding//GTPase activity//6-phosphofructo-2-kinase activity//G-protein beta/gamma-subunit complex binding//ATP binding -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-15464.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15468.1 BF_2 3.00 1.60 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15469.0 BF_2 6.00 0.32 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15474.0 BF_2 11.62 0.97 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15478.0 BF_2 68.30 1.12 2835 642927770 XP_008195398.1 736 8.3e-75 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 1.2e-07 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF02018 Carbohydrate binding domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds -- -- -- -- Cluster-15481.0 BF_2 10.00 0.46 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15495.0 BF_2 2.00 0.36 522 642914646 XP_008190298.1 853 4.1e-89 PREDICTED: transcription factor collier isoform X6 [Tribolium castaneum] 586559356 XM_006912897.1 192 4.14529e-94 PREDICTED: Pteropus alecto early B-cell factor 3 (EBF3), mRNA K09103 EBF, COE early B-cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K09103 P56721 827 1.8e-87 Transcription factor collier OS=Drosophila melanogaster GN=kn PE=2 SV=2 PF01833//PF16422 IPT/TIG domain//Transcription factor COE1 DNA-binding domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG3836 HLH transcription factor EBF/Olf-1 and related DNA binding proteins Cluster-15502.0 BF_2 3.00 0.47 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15504.0 BF_2 5.00 0.74 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15506.0 BF_2 2.00 0.37 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15507.0 BF_2 5.00 2.77 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15514.0 BF_2 3.00 0.31 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15530.0 BF_2 2.00 0.50 453 769835108 XP_011647659.1 280 1.0e-22 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15534.0 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15537.0 BF_2 3.00 0.56 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15538.0 BF_2 8.00 0.90 658 149287182 ABR23490.1 801 5.6e-83 60S ribosomal protein L9 [Ornithodoros parkeri] 575479783 XM_006679123.1 49 1.65037e-14 Batrachochytrium dendrobatidis JAM81 hypothetical protein (BATDEDRAFT_88560), mRNA K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 P51410 676 7.2e-70 60S ribosomal protein L9 OS=Mus musculus GN=Rpl9 PE=1 SV=2 PF00347 Ribosomal protein L6 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-15540.0 BF_2 6.00 1.87 421 675372720 KFM65622.1 195 6.7e-13 Motile sperm domain-containing protein 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q9CWP6 131 7.2e-07 Motile sperm domain-containing protein 2 OS=Mus musculus GN=Mospd2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-15541.0 BF_2 12.00 1.60 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15543.0 BF_2 4.00 0.82 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15554.0 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15559.0 BF_2 11.09 1.86 536 91091194 XP_972244.1 169 8.8e-10 PREDICTED: superoxide dismutase [Cu-Zn] [Tribolium castaneum]>gi|270014236|gb|EFA10684.1| hypothetical protein TcasGA2_TC011675 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872//GO:0004784 metal ion binding//superoxide dismutase activity -- -- -- -- Cluster-15568.0 BF_2 2.00 0.46 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- -- -- Cluster-15569.0 BF_2 13.00 0.48 1422 391340593 XP_003744624.1 1483 1.0e-161 PREDICTED: elongation factor 1-gamma-like [Metaseiulus occidentalis] -- -- -- -- -- K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 P12261 1330 2.3e-145 Elongation factor 1-gamma OS=Artemia salina PE=1 SV=3 PF13409//PF00647//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Elongation factor 1 gamma, conserved domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746//GO:0005515 translation elongation factor activity//protein binding GO:0005840 ribosome KOG1627 Translation elongation factor EF-1 gamma Cluster-15574.1 BF_2 2.00 0.31 561 675366933 KFM59835.1 242 3.1e-18 Acidic mammalian chitinase, partial [Stegodyphus mimosarum] -- -- -- -- -- K17523 CHI3L1_2 chitinase-3-like protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17523 P30922 189 1.8e-13 Chitinase-3-like protein 1 OS=Bos taurus GN=CHI3L1 PE=1 SV=3 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-15575.0 BF_2 6.00 23.85 260 241593536 XP_002404207.1 248 2.9e-19 ribosomal protein, putative [Ixodes scapularis]>gi|215500371|gb|EEC09865.1| ribosomal protein, putative [Ixodes scapularis] -- -- -- -- -- K02980 RP-S29e, RPS29 small subunit ribosomal protein S29e http://www.genome.jp/dbget-bin/www_bget?ko:K02980 Q4PM47 248 1.2e-20 40S ribosomal protein S29 OS=Ixodes scapularis GN=RpS29 PE=3 SV=1 PF01258//PF00253 Prokaryotic dksA/traR C4-type zinc finger//Ribosomal protein S14p/S29e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0008270//GO:0003723 structural constituent of ribosome//zinc ion binding//RNA binding GO:0005622//GO:0005840//GO:0015935 intracellular//ribosome//small ribosomal subunit KOG3506 40S ribosomal protein S29 Cluster-15578.0 BF_2 22.00 4.84 477 300791208 ADK34020.1 478 1.2e-45 ribosomal protein S15 [Prionchulus punctatus] 661902829 NM_001297462.1 148 1.08673e-69 Poecilia reticulata ribosomal protein S15 (rps15), mRNA K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 P62845 460 5.8e-45 40S ribosomal protein S15 OS=Rattus norvegicus GN=Rps15 PE=1 SV=2 PF00203 Ribosomal protein S19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0898 40S ribosomal protein S15 Cluster-15581.0 BF_2 13.00 2.27 527 115443550 YP_778569.1 380 2.9e-34 50S ribosomal protein L16 [Bigelowiella natans]>gi|122233792|sp|Q06J58.1|RK16_BIGNA RecName: Full=50S ribosomal protein L16, chloroplastic (chloroplast) [Bigelowiella natans]>gi|110810195|gb|ABG91401.1| 50S ribosomal protein L16 [Bigelowiella natans] 761231856 KM881642.1 527 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C442 566 3.3e-57 50S ribosomal protein L16, chloroplastic OS=Oryza sativa subsp. indica GN=rpl16 PE=3 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005739//GO:0005840//GO:0009507 mitochondrion//ribosome//chloroplast KOG3422 Mitochondrial ribosomal protein L16 Cluster-15583.0 BF_2 3.00 0.56 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15586.0 BF_2 5.00 1.23 457 391342968 XP_003745787.1 544 2.5e-53 PREDICTED: 60S ribosomal protein L44-like [Metaseiulus occidentalis] 241754614 XM_002406224.1 171 1.7001e-82 Ixodes scapularis 60S ribosomal protein L44, putative, mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 P48166 492 1.1e-48 60S ribosomal protein L44 OS=Caenorhabditis elegans GN=rpl-41 PE=3 SV=2 PF00935//PF00471//PF01184 Ribosomal protein L44//Ribosomal protein L33//GPR1/FUN34/yaaH family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular KOG3464 60S ribosomal protein L44 Cluster-15595.0 BF_2 1.00 0.77 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06736 Protein of unknown function (DUF1211) GO:0006813 potassium ion transport GO:0005267 potassium channel activity -- -- -- -- Cluster-15599.1 BF_2 8.00 0.58 860 -- -- -- -- -- 525346445 KC793917.1 74 2.76665e-28 Scylla paramamosain clone Scpa25 microsatellite sequence -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-15604.1 BF_2 5.00 0.68 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02511 Thymidylate synthase complementing protein GO:0006206//GO:0006231 pyrimidine nucleobase metabolic process//dTMP biosynthetic process GO:0050660//GO:0050797 flavin adenine dinucleotide binding//thymidylate synthase (FAD) activity -- -- -- -- Cluster-15618.0 BF_2 2.01 0.50 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15621.0 BF_2 4.00 0.58 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15629.0 BF_2 2.00 0.34 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05083 LST-1 protein GO:0000902//GO:0006955 cell morphogenesis//immune response -- -- GO:0016020 membrane -- -- Cluster-15638.0 BF_2 12.00 0.46 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15645.0 BF_2 7.00 0.70 706 67084055 AAY66962.1 574 1.3e-56 40S ribosomal protein S9 [Ixodes scapularis] 564241774 XM_006277637.1 128 2.15729e-58 PREDICTED: Alligator mississippiensis 40S ribosomal protein S9-like (LOC102570984), mRNA K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 547 7.0e-55 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF01479//PF00163 S4 domain//Ribosomal protein S4/S9 N-terminal domain -- -- GO:0003723//GO:0019843 RNA binding//rRNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-15649.0 BF_2 3.00 0.46 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15652.0 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15665.0 BF_2 2.00 0.34 535 642918886 XP_008191628.1 414 3.4e-38 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-15665.1 BF_2 1.00 0.85 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00483 Nucleotidyl transferase GO:0009058 biosynthetic process GO:0016779 nucleotidyltransferase activity -- -- -- -- Cluster-15667.0 BF_2 7.00 0.59 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15668.0 BF_2 5.00 0.44 760 327272489 XP_003221017.1 774 8.8e-80 PREDICTED: 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial [Anolis carolinensis] 333476408 CP002771.1 34 4.18589e-06 Marinomonas posidonica IVIA-Po-181, complete genome K00639 kbl, GCAT glycine C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00639 O75600 766 3.1e-80 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial OS=Homo sapiens GN=GCAT PE=1 SV=1 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1359 Glycine C-acetyltransferase/2-amino-3-ketobutyrate-CoA ligase Cluster-15669.0 BF_2 2.00 0.99 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15696.0 BF_2 3.00 0.35 643 225707320 ACO09506.1 233 4.0e-17 Heme-binding protein 2 [Osmerus mordax] -- -- -- -- -- -- -- -- -- Q9WU63 191 1.2e-13 Heme-binding protein 2 OS=Mus musculus GN=Hebp2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-15705.0 BF_2 4.63 0.59 614 91085393 XP_966738.1 541 7.4e-53 PREDICTED: Hermansky-Pudlak syndrome 3 protein homolog [Tribolium castaneum]>gi|270008408|gb|EFA04856.1| hypothetical protein TcasGA2_TC014910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15706.0 BF_2 22.00 1.34 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15709.0 BF_2 3.00 0.51 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02790 Cytochrome C oxidase subunit II, transmembrane domain GO:0022900 electron transport chain -- -- GO:0016021 integral component of membrane -- -- Cluster-15711.0 BF_2 2.00 0.86 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01922 SRP19 protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle -- -- Cluster-15718.0 BF_2 5.00 0.34 904 260797919 XP_002593948.1 638 6.1e-64 hypothetical protein BRAFLDRAFT_98245 [Branchiostoma floridae]>gi|229279180|gb|EEN49959.1| hypothetical protein BRAFLDRAFT_98245 [Branchiostoma floridae] -- -- -- -- -- K10707 VAPB, ALS8 vesicle-associated membrane protein-associated protein B http://www.genome.jp/dbget-bin/www_bget?ko:K10707 A2VDZ9 578 2.3e-58 Vesicle-associated membrane protein-associated protein B OS=Bos taurus GN=VAPB PE=2 SV=1 PF08172//PF06005 CASP C terminal//Protein of unknown function (DUF904) GO:0006891//GO:0000917//GO:0043093 intra-Golgi vesicle-mediated transport//barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0030173//GO:0005737 integral component of Golgi membrane//cytoplasm KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-15720.0 BF_2 6.00 0.45 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15721.0 BF_2 12.84 0.42 1551 392315969 AFM57703.1 760 7.5e-78 glutathione S-transferase D2 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VG95 423 3.7e-40 Glutathione S-transferase D5 OS=Drosophila melanogaster GN=GstD5 PE=3 SV=2 PF13409//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-15730.0 BF_2 4.00 0.86 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15734.0 BF_2 2.00 0.54 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-15737.0 BF_2 2.00 0.43 483 557757006 XP_005178236.1 180 4.2e-11 PREDICTED: leucine carboxyl methyltransferase 1 isoform X1 [Musca domestica]>gi|755859625|ref|XP_011290368.1| PREDICTED: leucine carboxyl methyltransferase 1 isoform X1 [Musca domestica] -- -- -- -- -- K18203 LCMT1 http://www.genome.jp/dbget-bin/www_bget?ko:K18203 Q3T0H0 156 1.1e-09 Leucine carboxyl methyltransferase 1 OS=Bos taurus GN=LCMT1 PE=2 SV=1 PF06112 Gammaherpesvirus capsid protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-15738.0 BF_2 2.00 0.54 441 -- -- -- -- -- 239764757 GQ220325.1 381 0 Vitis vinifera strain PN40024 mitochondrion, partial genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15745.0 BF_2 8.00 0.86 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15751.0 BF_2 9.00 0.46 1110 762050215 AJQ18907.1 1210 3.5e-130 acidic ribosomal protein P0 [Amblyomma cajennense] 817084545 XM_012409504.1 104 7.58365e-45 PREDICTED: Athalia rosae 60S acidic ribosomal protein P0 (LOC105691185), mRNA K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 P47826 1044 2.6e-112 60S acidic ribosomal protein P0 OS=Gallus gallus GN=RPLP0 PE=2 SV=1 PF00892//PF00466 EamA-like transporter family//Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG0815 60S acidic ribosomal protein P0 Cluster-15756.0 BF_2 11.00 0.38 1491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15761.0 BF_2 3.00 0.50 536 343183155 BAK61430.1 573 1.3e-56 myosin heavy chain type b [Marsupenaeus japonicus] 410509305 AB758441.1 125 7.4978e-57 Penaeus monodon MYH1 mRNA for myosin heavy chain type 1, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 441 1.0e-42 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF03242//PF02736//PF00063 Late embryogenesis abundant protein//Myosin N-terminal SH3-like domain//Myosin head (motor domain) GO:0006950 response to stress GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-15763.0 BF_2 7.00 0.45 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15768.0 BF_2 1.00 0.49 370 194885182 XP_001976397.1 203 6.9e-14 GG20036 [Drosophila erecta]>gi|190659584|gb|EDV56797.1| GG20036 [Drosophila erecta] 262401214 FJ774789.1 141 6.42163e-66 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15782.0 BF_2 1.00 0.48 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15784.0 BF_2 2.00 0.87 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15791.0 BF_2 4.00 0.42 689 241575102 XP_002403453.1 641 2.1e-64 pyst2, putative [Ixodes scapularis]>gi|215500230|gb|EEC09724.1| pyst2, putative [Ixodes scapularis] 852774870 XM_013025121.1 50 4.81661e-15 PREDICTED: Dipodomys ordii dual specificity phosphatase 16 (Dusp16), mRNA K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q16829 523 4.2e-52 Dual specificity protein phosphatase 7 OS=Homo sapiens GN=DUSP7 PE=1 SV=4 PF05706//PF00102//PF04179//PF00782//PF01573 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain//Bromovirus movement protein GO:0019988//GO:0006470//GO:0006570//GO:0046740//GO:0035335 charged-tRNA amino acid modification//protein dephosphorylation//tyrosine metabolic process//transport of virus in host, cell to cell//peptidyl-tyrosine dephosphorylation GO:0008138//GO:0004725//GO:0017017//GO:0043399//GO:0004721 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//MAP kinase tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//phosphoprotein phosphatase activity GO:0044156 host cell junction KOG1717 Dual specificity phosphatase Cluster-15796.0 BF_2 3.00 0.37 630 675377463 KFM70365.1 190 3.8e-12 Chondroitin proteoglycan 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-15797.0 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15803.0 BF_2 1.00 3.14 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06624 Ribosome associated membrane protein RAMP4 -- -- -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-15810.0 BF_2 9.89 0.77 827 307178650 EFN67292.1 363 4.3e-32 Transposable element Tc3 transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15816.1 BF_2 5.00 0.88 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15817.1 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15821.0 BF_2 2.00 9.30 255 734561771 KHN87786.1 238 4.2e-18 60S ribosomal protein L29 [Toxocara canis] -- -- -- -- -- K02905 RP-L29e, RPL29 large subunit ribosomal protein L29e http://www.genome.jp/dbget-bin/www_bget?ko:K02905 Q58DW3 222 1.2e-17 60S ribosomal protein L29 OS=Bos taurus GN=RPL29 PE=2 SV=3 PF01779 Ribosomal L29e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3504 60S ribosomal protein L29 Cluster-15822.0 BF_2 7.00 0.61 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15846.0 BF_2 4.00 1.07 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15849.0 BF_2 5.00 0.58 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15853.0 BF_2 2.00 0.42 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15856.0 BF_2 6.00 0.71 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15860.1 BF_2 4.00 0.43 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15872.0 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15891.0 BF_2 3.00 0.43 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15898.0 BF_2 3.00 1.26 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15906.0 BF_2 10.10 4.45 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15909.0 BF_2 6.00 0.85 582 573893538 XP_006634521.1 357 1.5e-31 PREDICTED: eukaryotic translation initiation factor 1b-like [Lepisosteus oculatus] 566179240 XM_006380250.1 224 7.57206e-112 Populus trichocarpa hypothetical protein (POPTR_0007s02520g) mRNA, complete cds K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 O48650 537 8.3e-54 Protein translation factor SUI1 homolog OS=Salix bakko PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-15911.0 BF_2 4.00 0.47 643 762155366 XP_011415782.1 636 7.4e-64 PREDICTED: 40S ribosomal protein S7-like [Crassostrea gigas]>gi|405972954|gb|EKC37696.1| 40S ribosomal protein S7 [Crassostrea gigas] 256709197 GQ422251.1 41 4.51014e-10 Rhabditoides inermis small subunit ribosomal protein 7 (rps-7) mRNA, complete cds K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 P02362 607 7.1e-62 40S ribosomal protein S7 OS=Xenopus laevis GN=rps7 PE=2 SV=2 PF01251 Ribosomal protein S7e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3320 40S ribosomal protein S7 Cluster-15916.0 BF_2 2.00 0.44 475 242017839 XP_002429393.1 497 7.2e-48 hypothetical protein Phum_PHUM431970 [Pediculus humanus corporis]>gi|212514312|gb|EEB16655.1| hypothetical protein Phum_PHUM431970 [Pediculus humanus corporis] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 414 1.3e-39 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-15918.0 BF_2 23.00 3.80 540 462269822 AGH24445.1 598 1.6e-59 NADH dehydrogenase subunit 4 (mitochondrion) [Reclinomonas americana ATCC 50284] 196052307 EU414247.2 495 0 Phyllostachys edulis NADH dehydrogenase subunit 4 gene, complete cds; mitochondrial -- -- -- -- P27572 860 2.7e-91 NADH-ubiquinone oxidoreductase chain 4 OS=Triticum aestivum GN=ND4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4845 NADH dehydrogenase, subunit 4 Cluster-15925.0 BF_2 3.00 1.62 361 501293108 BAN20561.1 505 6.5e-49 conserved hypothetical protein [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q2LZ59 463 2.0e-45 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG1903 Cell cycle-associated protein Cluster-15926.0 BF_2 3.00 1.47 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15927.0 BF_2 2.00 0.33 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15927.1 BF_2 58.00 0.68 3833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00868//PF01290 Transglutaminase family//Thymosin beta-4 family GO:0007015//GO:0018149 actin filament organization//peptide cross-linking GO:0003785 actin monomer binding -- -- -- -- Cluster-15927.2 BF_2 15.00 1.01 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15928.0 BF_2 75.76 5.66 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15949.0 BF_2 5.00 1.53 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15956.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15958.0 BF_2 4.00 0.53 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15962.0 BF_2 4.00 0.39 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15969.0 BF_2 16.00 1.16 865 -- -- -- -- -- 658309568 NM_001294008.1 343 8.09653e-178 Malus domestica auxin-responsive protein IAA27 (IAA12), mRNA >gnl|BL_ORD_ID|9263071 Malus x domestica ARF domain class transcription factor (IAA12) mRNA, complete cds -- -- -- -- Q9ZSY8 642 8.3e-66 Auxin-responsive protein IAA27 OS=Arabidopsis thaliana GN=IAA27 PE=1 SV=1 PF02309 AUX/IAA family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-15971.0 BF_2 10.00 2.22 475 426390256 XP_004061522.1 598 1.4e-59 PREDICTED: 60S ribosomal protein L28 isoform 1 [Gorilla gorilla gorilla] 209915582 NM_000991.4 472 0 Homo sapiens ribosomal protein L28 (RPL28), transcript variant 2, mRNA K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 P46779 599 4.4e-61 60S ribosomal protein L28 OS=Homo sapiens GN=RPL28 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-15974.0 BF_2 2.00 0.77 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15978.1 BF_2 1.00 4.50 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15979.2 BF_2 4.00 0.31 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15980.0 BF_2 17.18 0.40 2088 167234398 NP_001107822.1 1725 1.3e-189 wingless precursor [Tribolium castaneum] 642922428 XM_008194940.1 352 0 PREDICTED: Tribolium castaneum wingless (Wg), transcript variant X1, mRNA K03209 WNT1 wingless-type MMTV integration site family, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03209 P49340 1362 6.5e-149 Protein Wnt-1 OS=Bombyx mori GN=WNT-1 PE=2 SV=1 PF00110 wnt family GO:0007165//GO:0016055//GO:0007275 signal transduction//Wnt signaling pathway//multicellular organismal development GO:0005102 receptor binding GO:0005576 extracellular region KOG3913 Wnt family of developmental regulators Cluster-15983.0 BF_2 1.00 0.65 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15987.1 BF_2 1.00 0.33 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15988.0 BF_2 8.00 0.88 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-15995.0 BF_2 3.00 0.35 642 260814835 XP_002602119.1 358 1.3e-31 hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae]>gi|229287425|gb|EEN58131.1| hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae] 761231605 KM881639.1 642 0 Oryza glaberrima isolate 101328 chloroplast, complete genome K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 P0C2Z8 706 2.3e-73 ATP synthase subunit beta, chloroplastic OS=Oryza sativa subsp. indica GN=atpB PE=3 SV=1 PF02874 ATP synthase alpha/beta family, beta-barrel domain GO:0034220//GO:0046034//GO:0006754//GO:0015992 ion transmembrane transport//ATP metabolic process//ATP biosynthetic process//proton transport GO:0016820//GO:0015078//GO:0000166//GO:0017111 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//hydrogen ion transmembrane transporter activity//nucleotide binding//nucleoside-triphosphatase activity GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-15996.0 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16000.1 BF_2 8.00 0.43 1068 391346495 XP_003747508.1 379 7.8e-34 PREDICTED: uncharacterized protein LOC100908890 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01290//PF02205 Thymosin beta-4 family//WH2 motif GO:0007015 actin filament organization GO:0003785//GO:0003779 actin monomer binding//actin binding -- -- KOG4794 Thymosin beta Cluster-16011.0 BF_2 3.00 1.16 394 82795531 ABB91679.1 323 8.9e-28 calcified cuticle protein CP15.0 [Callinectes sapidus] 82795530 DQ288154.1 294 6.09946e-151 Callinectes sapidus calcified cuticle protein CP15.0 mRNA, complete cds -- -- -- -- P81583 223 1.4e-17 Cuticle protein CP1499 OS=Cancer pagurus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16012.0 BF_2 11.00 1.89 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16013.0 BF_2 14.00 0.36 1892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16018.0 BF_2 37.00 1.58 1269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16021.0 BF_2 5.00 43.40 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16026.0 BF_2 9.00 1.10 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16029.0 BF_2 3.00 1.17 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16030.0 BF_2 17.00 0.57 1532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16034.0 BF_2 5.00 1.65 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16036.0 BF_2 5.00 0.61 631 290783836 ADD62496.1 173 3.5e-10 gastrolith protein 10 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16940 Chloroplast envelope transporter -- -- -- -- GO:0009507 chloroplast -- -- Cluster-16055.0 BF_2 4.00 0.36 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16056.0 BF_2 7.00 0.87 624 241671010 XP_002399960.1 497 9.5e-48 60S ribosomal protein L23, putative [Ixodes scapularis]>gi|215506218|gb|EEC15712.1| 60S ribosomal protein L23, putative [Ixodes scapularis] 402767190 NM_001249970.2 65 1.99021e-23 Glycine max uncharacterized LOC100527754 (LOC100527754), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 426 6.6e-41 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0000166 structural constituent of ribosome//nucleotide binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-16063.0 BF_2 3.00 0.52 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00522 VPR/VPX protein GO:0019058 viral life cycle -- -- GO:0042025 host cell nucleus -- -- Cluster-16065.0 BF_2 3.00 3.44 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16068.0 BF_2 2.00 0.49 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16068.1 BF_2 2.00 0.34 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16071.0 BF_2 3.00 0.35 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08533 Beta-galactosidase C-terminal domain GO:0006012//GO:0006027//GO:0006687//GO:0046486 galactose metabolic process//glycosaminoglycan catabolic process//glycosphingolipid metabolic process//glycerolipid metabolic process GO:0004565 beta-galactosidase activity GO:0009341 beta-galactosidase complex -- -- Cluster-16072.0 BF_2 3.00 1.45 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16075.0 BF_2 3.00 1.21 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04627 Mitochondrial ATP synthase epsilon chain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-16078.0 BF_2 2.00 0.31 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00831 Ribosomal L29 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-16080.0 BF_2 3.00 0.48 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064 Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0007178 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-16081.1 BF_2 5.00 0.88 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16519//PF00672//PF04513//PF08653 Tetramerisation domain of TRPM//HAMP domain//Baculovirus polyhedron envelope protein, PEP, C terminus//DASH complex subunit Dam1 GO:0051262//GO:0007165//GO:0008608 protein tetramerization//signal transduction//attachment of spindle microtubules to kinetochore GO:0005198//GO:0004871 structural molecule activity//signal transducer activity GO:0072686//GO:0016021//GO:0019028//GO:0019031//GO:0042729 mitotic spindle//integral component of membrane//viral capsid//viral envelope//DASH complex -- -- Cluster-16085.0 BF_2 7.00 0.43 967 457867021 CCQ18621.1 447 9.2e-42 Translation initiation factor 1A [Sycon ciliatum] 612016962 XM_007493441.1 114 1.81542e-50 PREDICTED: Monodelphis domestica eukaryotic translation initiation factor 1A, X-chromosomal-like (LOC100013498), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 Q6GVM3 421 3.9e-40 Eukaryotic translation initiation factor 1A, Y-chromosomal OS=Pan troglodytes GN=EIF1AY PE=2 SV=3 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-16091.0 BF_2 4.00 0.89 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16094.1 BF_2 3.00 1.34 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16101.0 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16103.0 BF_2 5.00 0.39 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16108.0 BF_2 16.50 0.88 1071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-16110.0 BF_2 3.00 2.07 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16115.0 BF_2 10.00 1.23 626 282721012 NP_001164206.1 287 2.1e-23 NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) [Tribolium castaneum]>gi|642927503|ref|XP_008195295.1| PREDICTED: NADH dehydrogenase (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) isoform X1 [Tribolium castaneum]>gi|270011055|gb|EFA07503.1| hypothetical protein TcasGA2_TC009578 [Tribolium castaneum] -- -- -- -- -- K03938 NDUFS5 NADH dehydrogenase (ubiquinone) Fe-S protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16122.0 BF_2 5.00 1.21 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16129.0 BF_2 4.00 0.36 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16133.0 BF_2 7.00 0.60 777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00283 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits GO:0015979 photosynthesis -- -- -- -- -- -- Cluster-16135.0 BF_2 6.00 0.33 1059 554886961 XP_005953034.1 255 1.9e-19 PREDICTED: C-type lectin domain family 4 member M-like [Haplochromis burtoni] -- -- -- -- -- K17513 CLEC17A C-type lectin superfamily 17 member A http://www.genome.jp/dbget-bin/www_bget?ko:K17513 P20693 190 2.6e-13 Low affinity immunoglobulin epsilon Fc receptor OS=Mus musculus GN=Fcer2 PE=2 SV=1 PF05432 Bone sialoprotein II (BSP-II) GO:0001503//GO:0007155 ossification//cell adhesion -- -- GO:0005576 extracellular region -- -- Cluster-16142.0 BF_2 17.15 0.31 2634 642918045 XP_008198993.1 865 8.5e-90 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9B9 337 5.9e-30 Choline transporter-like protein 1 OS=Torpedo marmorata GN=slc44a1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-16146.0 BF_2 32.00 1.13 1470 108773740 ABG11961.1 1756 2.3e-193 tail muscle elongation factor 1 gamma [Procambarus clarkii] 262401138 FJ774751.1 447 0 Scylla paramamosain elongation factor 1 gamma mRNA, partial cds K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 Q9NJH0 1262 1.8e-137 Elongation factor 1-gamma OS=Drosophila melanogaster GN=Ef1gamma PE=2 SV=2 PF13409//PF01239//PF00647//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Protein prenyltransferase alpha subunit repeat//Elongation factor 1 gamma, conserved domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006448//GO:0006414//GO:0018342 regulation of translational elongation//translational elongation//protein prenylation GO:0005515//GO:0008318//GO:0003746 protein binding//protein prenyltransferase activity//translation elongation factor activity GO:0005840 ribosome KOG0867 Glutathione S-transferase Cluster-16148.0 BF_2 2.00 0.62 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16157.0 BF_2 4.00 0.50 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16161.0 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16163.0 BF_2 2.00 0.98 370 67083703 AAY66786.1 423 2.1e-39 mitochondrial truncated thioredoxin-dependent peroxide reductase precursor, partial [Ixodes scapularis] -- -- -- -- -- K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9Y7F0 375 3.2e-35 Peroxiredoxin TSA1 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=TSA1 PE=2 SV=1 PF08534//PF00578//PF10417 Redoxin//AhpC/TSA family//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-16168.0 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16170.0 BF_2 1.00 0.49 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16175.0 BF_2 19.31 2.36 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505 Clostridium enterotoxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-16175.1 BF_2 4.69 0.38 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505 Clostridium enterotoxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-16176.0 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16183.0 BF_2 6.00 0.34 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16192.0 BF_2 3.43 0.36 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16193.0 BF_2 1.00 0.52 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-16199.0 BF_2 3.00 0.35 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16204.0 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16222.0 BF_2 44.00 4.15 731 253683402 NP_001153391.1 623 2.7e-62 ribosomal protein L6 [Nasonia vitripennis] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q6QMZ4 521 7.5e-52 60S ribosomal protein L6 OS=Chinchilla lanigera GN=RPL6 PE=2 SV=3 PF01159 Ribosomal protein L6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-16225.0 BF_2 2.00 0.59 429 564287255 AHB84653.1 151 8.6e-08 leucine-rich repeat protein [Scylla serrata] 381145578 JQ681527.1 416 0 Scylla paramamosain leucine-rich repeat proteins (LRR) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16232.0 BF_2 14.00 1.07 837 470455770 XP_004340994.1 206 7.0e-14 Zn-finger in Ran binding protein and others domain containing protein [Acanthamoeba castellanii str. Neff]>gi|440797856|gb|ELR18930.1| Zn-finger in Ran binding protein and others domain containing protein [Acanthamoeba castellanii str. Neff] -- -- -- -- -- -- -- -- -- P32770 124 9.3e-06 Asparagine-rich protein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NRP1 PE=1 SV=2 PF06003//PF00301//PF00641//PF07562 Survival motor neuron protein (SMN)//Rubredoxin//Zn-finger in Ran binding protein and others//Nine Cysteines Domain of family 3 GPCR GO:0006397//GO:0007186 mRNA processing//G-protein coupled receptor signaling pathway GO:0004930//GO:0003723//GO:0008270//GO:0005506 G-protein coupled receptor activity//RNA binding//zinc ion binding//iron ion binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-16238.0 BF_2 8.00 0.79 709 159145716 ABW90395.1 752 2.9e-77 putative ribosomal protein L18 [Barentsia elongata] 241672695 XM_002400272.1 80 1.04447e-31 Ixodes scapularis ribosomal protein L18, putative, mRNA K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q4PM04 740 2.9e-77 60S ribosomal protein L18 OS=Ixodes scapularis GN=RpL18 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1714 60s ribosomal protein L18 Cluster-16241.0 BF_2 21.92 0.95 1254 478251147 ENN71623.1 971 2.1e-102 hypothetical protein YQE_11722, partial [Dendroctonus ponderosae]>gi|546685809|gb|ERL95252.1| hypothetical protein D910_12519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16241.1 BF_2 7.93 0.34 1266 478251147 ENN71623.1 956 1.2e-100 hypothetical protein YQE_11722, partial [Dendroctonus ponderosae]>gi|546685809|gb|ERL95252.1| hypothetical protein D910_12519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16249.0 BF_2 26.28 0.32 3700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0008277//GO:0006886//GO:0015031 regulation of G-protein coupled receptor protein signaling pathway//intracellular protein transport//protein transport GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-16250.0 BF_2 12.59 0.39 1650 270004026 EFA00474.1 821 6.8e-85 hypothetical protein TcasGA2_TC003333 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14913 398 3.1e-37 4-coumarate--CoA ligase 1 OS=Petroselinum crispum GN=4CL2 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-16250.1 BF_2 34.41 0.90 1880 270004026 EFA00474.1 963 2.6e-101 hypothetical protein TcasGA2_TC003333 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14913 485 2.9e-47 4-coumarate--CoA ligase 1 OS=Petroselinum crispum GN=4CL2 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-16267.0 BF_2 5.00 0.36 862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16271.0 BF_2 5.00 0.39 830 241581367 XP_002403503.1 570 4.3e-56 fatty acid synthase, putative [Ixodes scapularis]>gi|215502217|gb|EEC11711.1| fatty acid synthase, putative [Ixodes scapularis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 526 2.2e-52 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00106 short chain dehydrogenase GO:0006633//GO:0008152//GO:0042967 fatty acid biosynthetic process//metabolic process//acyl-carrier-protein biosynthetic process GO:0016491//GO:0016297 oxidoreductase activity//acyl-[acyl-carrier-protein] hydrolase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-16275.0 BF_2 3.00 0.45 563 391348627 XP_003748547.1 443 1.6e-41 PREDICTED: angiotensin-converting enzyme-like [Metaseiulus occidentalis] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10714 326 2.4e-29 Angiotensin-converting enzyme OS=Drosophila melanogaster GN=Ance PE=1 SV=3 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane -- -- Cluster-16279.0 BF_2 1.00 0.98 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16283.0 BF_2 7.00 0.44 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16294.0 BF_2 6.00 0.52 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16306.0 BF_2 6.00 0.49 796 332374070 AEE62176.1 295 3.2e-24 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9NWM0 180 2.9e-12 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01593//PF07825 Flavin containing amine oxidoreductase//Excisionase-like protein GO:0006310//GO:0055114 DNA recombination//oxidation-reduction process GO:0003677//GO:0016491 DNA binding//oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-16308.0 BF_2 1.00 0.43 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16310.0 BF_2 6.00 0.65 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16315.0 BF_2 24.00 1.70 879 642912160 XP_008200831.1 344 7.4e-30 PREDICTED: homeobox protein MOX-2 [Tribolium castaneum] 795108199 XM_012026605.1 53 1.33557e-16 PREDICTED: Vollenhovia emeryi homeobox protein MOX-2 (LOC105569842), mRNA K09322 MEOX, MOX homeobox protein MOX http://www.genome.jp/dbget-bin/www_bget?ko:K09322 P39020 317 4.1e-28 Homeobox protein MOX-2 OS=Rattus norvegicus GN=Meox2 PE=2 SV=1 PF00046//PF06056 Homeobox domain//Putative ATPase subunit of terminase (gpP-like) GO:0019069 viral capsid assembly GO:0005524//GO:0003677 ATP binding//DNA binding -- -- -- -- Cluster-16320.0 BF_2 3.00 0.64 484 642925224 XP_008194474.1 214 4.8e-15 PREDICTED: uncharacterized protein LOC100142004 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16327.0 BF_2 2.00 0.32 545 871218375 XP_012935387.1 167 1.5e-09 PREDICTED: ribosome-binding protein 1-like isoform X10 [Aplysia californica] -- -- -- -- -- -- -- -- -- Q9P2E9 123 7.9e-06 Ribosome-binding protein 1 OS=Homo sapiens GN=RRBP1 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-16328.0 BF_2 8.00 0.44 1046 241998814 XP_002434050.1 1169 1.9e-125 60S ribosomal protein L5, putative [Ixodes scapularis]>gi|215495809|gb|EEC05450.1| 60S ribosomal protein L5, putative [Ixodes scapularis] 61675146 CR938328.1 135 4.17293e-62 Single read from an extremity of a full-length cDNA clone made from Aedes aegypti total adult females. 5-prime end of clone KW0AAA2YC24AAM1 from strain Liverpool of Aedes aegypti (yellow fever mosquito) K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 O76190 1100 7.8e-119 60S ribosomal protein L5 OS=Bombyx mori GN=RpL5 PE=2 SV=1 PF02926//PF00861 THUMP domain//Ribosomal L18p/L5e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003723//GO:0008097 structural constituent of ribosome//RNA binding//5S rRNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG0875 60S ribosomal protein L5 Cluster-16332.0 BF_2 3.00 0.54 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16357.1 BF_2 2.00 0.41 492 -- -- -- -- -- 168277723 AB384984.1 492 0 Synthetic construct DNA, clone: pF1KB4737, Homo sapiens COL1A2 gene for collagen alpha-2(I) chain precursor, complete cds, without stop codon, in Flexi system -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-16358.0 BF_2 2.00 0.53 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16359.0 BF_2 3.00 0.71 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16359.1 BF_2 1.00 0.61 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16375.0 BF_2 3.99 0.35 770 642923718 XP_974278.2 641 2.3e-64 PREDICTED: EF-hand domain-containing family member C2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13202//PF00036//PF13405//PF13499 EF hand//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-16376.0 BF_2 4.00 0.85 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16379.1 BF_2 3.00 0.54 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16380.0 BF_2 4.00 0.36 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16382.0 BF_2 4.00 0.54 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16393.0 BF_2 4.00 0.49 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16401.0 BF_2 3.00 0.34 652 241862486 XP_002416387.1 601 8.6e-60 glutathione S-transferase, putative [Ixodes scapularis]>gi|215510601|gb|EEC20054.1| glutathione S-transferase, putative, partial [Ixodes scapularis] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9WVL0 569 1.8e-57 Maleylacetoacetate isomerase OS=Mus musculus GN=Gstz1 PE=1 SV=1 PF13409//PF10568//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Outer mitochondrial membrane transport complex protein//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006626 protein targeting to mitochondrion GO:0005515//GO:0016853 protein binding//isomerase activity GO:0005741 mitochondrial outer membrane KOG0868 Glutathione S-transferase Cluster-16403.0 BF_2 1.00 0.45 379 321475172 EFX86135.1 168 8.1e-10 hypothetical protein DAPPUDRAFT_313160 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q6PD31 131 6.5e-07 Trafficking kinesin-binding protein 1 OS=Mus musculus GN=Trak1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16406.0 BF_2 2.00 1.07 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16408.0 BF_2 8.00 0.75 731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16409.0 BF_2 1.00 0.45 379 552968764 AGY49577.1 460 1.1e-43 pelle-like kinase [Scylla paramamosain] 552968763 KF155698.1 379 0 Scylla paramamosain pelle-like kinase (Pelle) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16410.0 BF_2 3.00 1.25 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16416.1 BF_2 13.00 1.68 610 270008861 EFA05309.1 269 2.5e-21 hypothetical protein TcasGA2_TC015467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5I0G3 126 4.0e-06 Putative malate dehydrogenase 1B OS=Homo sapiens GN=MDH1B PE=2 SV=1 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- -- -- Cluster-16417.1 BF_2 2.00 0.57 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16419.0 BF_2 9.00 0.42 1175 65332126 AAY42205.1 907 5.1e-95 troponin T [Haemaphysalis qinghaiensis] -- -- -- -- -- K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 Q9XZ71 568 4.3e-57 Troponin T OS=Periplaneta americana GN=TNT PE=2 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3634 Troponin Cluster-16428.0 BF_2 4.00 0.41 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16431.0 BF_2 99.00 2.95 1689 432863587 XP_004070140.1 486 4.8e-46 PREDICTED: GDP-D-glucose phosphorylase 1 [Oryzias latipes] 645241229 XM_008228760.1 675 0 PREDICTED: Prunus mume GDP-L-galactose phosphorylase 1 (LOC103326528), mRNA K15630 VTC2 GDP-D-glucose phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K15630 Q8RWE8 1578 4.7e-174 GDP-L-galactose phosphorylase 1 OS=Arabidopsis thaliana GN=VTC2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2720 Predicted hydrolase (HIT family) Cluster-16431.1 BF_2 11.00 1.19 674 -- -- -- -- -- 658028916 XM_008351675.1 133 3.41377e-61 PREDICTED: Malus x domestica GDP-L-galactose phosphorylase 1-like (LOC103413187), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16439.0 BF_2 4.00 0.34 776 746841421 XP_011050903.1 531 1.3e-51 PREDICTED: probable glutathione peroxidase 2 isoform X4 [Acromyrmex echinatior] -- -- -- -- -- K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 O23968 490 3.1e-48 Probable phospholipid hydroperoxide glutathione peroxidase OS=Helianthus annuus GN=GPXHA-2 PE=2 SV=1 PF08534//PF00578//PF00255 Redoxin//AhpC/TSA family//Glutathione peroxidase GO:0006749//GO:0006979//GO:0006804//GO:0055114 glutathione metabolic process//response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0016209//GO:0004602//GO:0016491 antioxidant activity//glutathione peroxidase activity//oxidoreductase activity -- -- KOG1651 Glutathione peroxidase Cluster-16441.0 BF_2 4.00 1.08 442 260814835 XP_002602119.1 296 1.4e-24 hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae]>gi|229287425|gb|EEN58131.1| hypothetical protein BRAFLDRAFT_125760 [Branchiostoma floridae] 761231940 KM881643.1 442 0 Oryza officinalis chloroplast, complete genome K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 P69443 368 2.5e-34 ATP synthase epsilon chain, chloroplastic OS=Triticum aestivum GN=atpE PE=3 SV=1 PF00306//PF02823 ATP synthase alpha/beta chain, C terminal domain//ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015986//GO:0015992//GO:0005975//GO:0006119//GO:0015991 ATP synthesis coupled proton transport//proton transport//carbohydrate metabolic process//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046933//GO:0046961//GO:0008553//GO:0005524//GO:0016757//GO:0016820 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//hydrogen-exporting ATPase activity, phosphorylative mechanism//ATP binding//transferase activity, transferring glycosyl groups//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0045261//GO:0045259//GO:0033178 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-16442.0 BF_2 4.00 0.55 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16443.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16450.0 BF_2 2.00 0.39 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16457.0 BF_2 1.00 0.55 360 546676107 ERL87174.1 173 2.0e-10 hypothetical protein D910_04574 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16460.0 BF_2 8.00 0.43 1067 443614319 AGC96521.1 1180 1.0e-126 C-type lectin, partial [Scylla paramamosain] 443614318 JQ864184.1 707 0 Scylla paramamosain clone PXQ034F02 C-type lectin mRNA, partial cds -- -- -- -- -- -- -- -- PF01830 Peptidase C7 family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-16461.0 BF_2 2.00 0.69 407 241999460 XP_002434373.1 415 2.0e-38 conserved hypothetical protein [Ixodes scapularis]>gi|215497703|gb|EEC07197.1| conserved hypothetical protein [Ixodes scapularis] -- -- -- -- -- K12160 SUMO, SMT3 small ubiquitin-related modifier http://www.genome.jp/dbget-bin/www_bget?ko:K12160 Q7SZ22 361 1.5e-33 Small ubiquitin-related modifier 3 OS=Xenopus laevis GN=sumo3 PE=3 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG1769 Ubiquitin-like proteins Cluster-16462.0 BF_2 2.00 16.73 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16464.0 BF_2 7.00 1.08 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12603 Protein of unknown function (DUF3770) GO:0006144 purine nucleobase metabolic process GO:0003968 RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-16466.0 BF_2 17.00 0.78 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16472.0 BF_2 11.00 0.47 1263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16476.0 BF_2 3.00 0.46 558 558145805 XP_006119543.1 308 7.0e-26 PREDICTED: acyl-CoA-binding domain-containing protein 7-like [Pelodiscus sinensis] -- -- -- -- -- K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 P45883 303 1.1e-26 Acyl-CoA-binding protein homolog OS=Pelophylax ridibundus PE=1 SV=2 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-16482.0 BF_2 3.00 1.07 403 -- -- -- -- -- 315057124 HM345951.1 47 1.26628e-13 Scylla paramamosain arasin-like protein mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16511.0 BF_2 8.00 1.01 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16515.0 BF_2 3.00 0.33 672 675366365 KFM59267.1 216 3.9e-15 hypothetical protein X975_13203, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- O60356 131 1.2e-06 Nuclear protein 1 OS=Homo sapiens GN=NUPR1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16518.1 BF_2 5.00 0.77 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16523.0 BF_2 43.00 1.86 1256 383858571 XP_003704774.1 1353 1.1e-146 PREDICTED: 60S ribosomal protein L4 [Megachile rotundata] 543354349 XM_005521649.1 171 4.89272e-82 PREDICTED: Pseudopodoces humilis ribosomal protein L4 (RPL4), mRNA K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P08429 1324 1.0e-144 60S ribosomal protein L4-A OS=Xenopus laevis GN=rpl4-a PE=2 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-16523.2 BF_2 3.00 0.34 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16524.0 BF_2 3.00 0.37 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16531.0 BF_2 2.00 0.55 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16534.0 BF_2 6.00 0.71 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16535.0 BF_2 5.00 0.39 825 391338271 XP_003743483.1 212 1.4e-14 PREDICTED: protein NDRG3-like [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16539.0 BF_2 2.00 3.05 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16552.0 BF_2 6.00 0.46 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16564.0 BF_2 18.71 0.40 2265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16565.0 BF_2 5.00 0.35 880 759036617 XP_011345477.1 469 2.4e-44 PREDICTED: histone H2A.V isoform X2 [Cerapachys biroi] 24111225 NM_153644.1 131 5.83739e-60 Danio rerio H2A histone family, member Va (h2afva), mRNA >gnl|BL_ORD_ID|1525629 Danio rerio histone variant H2A.F/Z mRNA, complete cds K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P08991 469 9.7e-46 Histone H2A.V (Fragment) OS=Strongylocentrotus purpuratus GN=H2A.F/Z PE=1 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1757 Histone 2A Cluster-16573.0 BF_2 9.00 0.84 734 114153086 ABI52709.1 559 7.2e-55 ribosomal protein S19 [Argas monolakensis] -- -- -- -- -- K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P39018 475 1.6e-46 40S ribosomal protein S19a OS=Drosophila melanogaster GN=RpS19a PE=1 SV=3 PF01090 Ribosomal protein S19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-16575.0 BF_2 6.00 0.33 1058 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16579.0 BF_2 9.00 0.93 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9LS40 456 2.4e-44 Protein ASPARTIC PROTEASE IN GUARD CELL 1 OS=Arabidopsis thaliana GN=ASPG1 PE=1 SV=1 PF00026 Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-16604.0 BF_2 22.00 0.62 1767 223585573 ACM91676.1 2245 5.5e-250 F1F0-ATP synthase beta subunit [Marsupenaeus japonicus] 329565547 JF303646.1 876 0 Penaeus monodon ATP synthase beta subunit mRNA, complete cds K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q05825 1990 8.3e-222 ATP synthase subunit beta, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-beta PE=1 SV=3 PF00931//PF03193//PF00005//PF00006//PF01637//PF00004//PF02874//PF00306 NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//ATP synthase alpha/beta family, beta-barrel domain//ATP synthase alpha/beta chain, C terminal domain GO:0015991//GO:0046034//GO:0015992 ATP hydrolysis coupled proton transport//ATP metabolic process//proton transport GO:0016820//GO:0003924//GO:0043531//GO:0005524//GO:0016887//GO:0005525 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//GTPase activity//ADP binding//ATP binding//ATPase activity//GTP binding GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-16605.0 BF_2 7.76 0.33 1261 225712314 ACO12003.1 998 1.5e-105 Transposable element Tc3 transposase [Lepeophtheirus salmonis] 3676297 U97104.1 382 0 BTU97104 Bactrocera tryoni membrane transporter (white) gene, complete cds -- -- -- -- -- -- -- -- PF01527 Transposase GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-16612.0 BF_2 2.00 1.02 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16613.0 BF_2 3.00 0.69 469 675385960 KFM78857.1 567 5.4e-56 Serine/threonine-protein kinase pim-3, partial [Stegodyphus mimosarum] 768944336 XM_003972918.2 55 5.32891e-18 PREDICTED: Takifugu rubripes Pim-3 proto-oncogene, serine/threonine kinase (pim3), mRNA K04702 PIM1 proto-oncogene serine/threonine-protein kinase Pim-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04702 Q86V86 541 2.3e-54 Serine/threonine-protein kinase pim-3 OS=Homo sapiens GN=PIM3 PE=1 SV=3 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-16629.0 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16630.0 BF_2 1.00 2.45 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16634.0 BF_2 2.00 0.41 491 114153290 ABI52811.1 493 2.2e-47 cytochrome c oxidase subunit Va [Argas monolakensis] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 402 3.2e-38 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0045277 mitochondrial inner membrane//respiratory chain complex IV KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-16643.0 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01104 Bunyavirus non-structural protein NS-s GO:0016032 viral process -- -- -- -- -- -- Cluster-16645.0 BF_2 3.00 0.39 613 759052896 XP_011335597.1 320 3.1e-27 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [Cerapachys biroi]>gi|607362086|gb|EZA56346.1| NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial [Cerapachys biroi] -- -- -- -- -- K03939 NDUFS6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03939 Q4R5X8 234 1.2e-18 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial OS=Macaca fascicularis GN=NDUFS6 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3456 NADH:ubiquinone oxidoreductase, NDUFS6/13 kDa subunit Cluster-16648.0 BF_2 4.00 0.38 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03381//PF00130//PF00628 LEM3 (ligand-effect modulator 3) family / CDC50 family//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger GO:0035556 intracellular signal transduction GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-16651.0 BF_2 2.00 1.03 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16654.0 BF_2 1.00 0.55 359 -- -- -- -- -- 325260834 HM999008.1 350 0 Oryza nivara clone BAC ORBBa0014L06, complete sequence -- -- -- -- -- -- -- -- PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-16654.2 BF_2 3.00 0.58 503 -- -- -- -- -- 38637384 AP005491.3 442 0 Oryza sativa Japonica Group genomic DNA, chromosome 8, BAC clone:OSJNBa0062G05 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16657.0 BF_2 2.00 0.54 441 262306583 ACY45884.1 609 6.9e-61 AMP deaminase, partial [Lynceus sp. 'Lyn'] 617631450 XM_007529342.1 84 3.77399e-34 PREDICTED: Erinaceus europaeus adenosine monophosphate deaminase 2 (AMPD2), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q02356 558 2.3e-56 AMP deaminase 2 OS=Rattus norvegicus GN=Ampd2 PE=2 SV=2 PF00578//PF00962 AhpC/TSA family//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0016491//GO:0019239//GO:0016209 oxidoreductase activity//deaminase activity//antioxidant activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-16659.0 BF_2 6.00 1.22 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16660.0 BF_2 1.00 0.38 396 -- -- -- -- -- 58197543 AP008246.1 369 0 Oryza sativa Japonica Group genomic DNA, chromosome 1, BAC clone:B1642C07 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16663.0 BF_2 1.00 0.36 403 703624008 AIW42687.1 485 1.5e-46 phospholipid-hydroperoxide glutathione peroxidase [Scylla paramamosain] 703624007 KM275218.1 341 4.66477e-177 Scylla paramamosain phospholipid-hydroperoxide glutathione peroxidase mRNA, complete cds K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q9N2J2 320 8.4e-29 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Bos taurus GN=GPX4 PE=2 SV=2 PF00255 Glutathione peroxidase GO:0006804//GO:0055114//GO:0006979//GO:0006749 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress//glutathione metabolic process GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-16666.0 BF_2 91.00 11.44 620 642932746 XP_008196970.1 145 6.2e-07 PREDICTED: uncharacterized protein LOC103314027 [Tribolium castaneum]>gi|270012439|gb|EFA08887.1| hypothetical protein TcasGA2_TC006588 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16673.0 BF_2 3.00 2.56 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16674.0 BF_2 3.00 0.38 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16690.0 BF_2 2.00 0.31 559 391344006 XP_003746296.1 391 1.7e-35 PREDICTED: uncharacterized protein LOC100903666 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16691.0 BF_2 4.00 0.40 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16699.0 BF_2 9.00 0.59 928 72139268 AAZ66373.1 779 2.8e-80 O-methyltransferase [Fenneropenaeus chinensis] -- -- -- -- -- -- -- -- -- Q86IC8 458 1.9e-44 Probable caffeoyl-CoA O-methyltransferase 2 OS=Dictyostelium discoideum GN=omt6 PE=1 SV=1 PF01596//PF04288//PF01209 O-methyltransferase//MukE-like family//ubiE/COQ5 methyltransferase family GO:0007059//GO:0030261 chromosome segregation//chromosome condensation GO:0008171//GO:0008168 O-methyltransferase activity//methyltransferase activity GO:0005737 cytoplasm KOG1663 O-methyltransferase Cluster-16700.0 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16708.0 BF_2 6.00 0.47 818 391326405 XP_003737707.1 322 2.4e-27 PREDICTED: ninjurin-2-like [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q9NZG7 214 3.3e-16 Ninjurin-2 OS=Homo sapiens GN=NINJ2 PE=1 SV=1 PF04923 Ninjurin GO:0042246//GO:0007155 tissue regeneration//cell adhesion -- -- GO:0016021 integral component of membrane -- -- Cluster-16713.0 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16713.1 BF_2 1.00 1.37 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16729.0 BF_2 6.79 0.73 675 815820320 XP_012231375.1 140 2.6e-06 PREDICTED: lipase 3-like [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-16731.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16733.0 BF_2 3.00 0.32 684 260594183 ACX46386.1 421 6.7e-39 prepro-calcitonin-like diuretic hormone [Homarus americanus] -- -- -- -- -- -- -- -- -- Q9VLK4 198 2.0e-14 Diuretic hormone class 2 OS=Drosophila melanogaster GN=Dh31 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16743.1 BF_2 2.00 21.86 231 292379266 ADE21100.1 375 4.9e-34 translation elongation factor 1-alpha [Bertiella macrospora] 631373337 XM_007922858.1 206 2.79064e-102 Pseudocercospora fijiensis CIRAD86 hypothetical protein mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q00251 384 1.8e-36 Elongation factor 1-alpha OS=Aureobasidium pullulans GN=TEF1 PE=3 SV=1 PF03144 Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-16753.0 BF_2 2.00 0.35 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16754.0 BF_2 20.00 2.63 605 506965582 AGM32143.1 773 9.1e-80 60S ribosomal protein L11 [Coptotermes formosanus] 884959036 XM_010900292.2 188 8.11632e-92 PREDICTED: Esox lucius ribosomal protein L11 (rpl11), transcript variant X1, mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 Q94300 734 1.2e-76 60S ribosomal protein L11 OS=Caenorhabditis elegans GN=rpl-11.1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-16755.0 BF_2 6.00 0.70 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16760.0 BF_2 1.00 0.46 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16777.0 BF_2 3.00 0.35 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16779.0 BF_2 11.00 0.97 761 564367712 XP_006244722.1 1001 4.2e-106 PREDICTED: 60S ribosomal protein L10a-like isoform X2 [Rattus norvegicus] 164692980 AK313181.1 535 0 Homo sapiens cDNA, FLJ93680, Homo sapiens ribosomal protein L10a (RPL10A), mRNA K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q5E9E6 970 6.8e-104 60S ribosomal protein L10a OS=Bos taurus GN=RPL10A PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1570 60S ribosomal protein L10A Cluster-16790.0 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16794.0 BF_2 2.00 0.61 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16797.0 BF_2 4.00 0.45 661 674591309 CDS29849.1 397 4.0e-36 brain protein 44 [Hymenolepis microstoma] -- -- -- -- -- -- -- -- -- O95563 326 2.8e-29 Mitochondrial pyruvate carrier 2 OS=Homo sapiens GN=MPC2 PE=1 SV=1 PF03650 Uncharacterised protein family (UPF0041) GO:0006850 mitochondrial pyruvate transport -- -- GO:0005743 mitochondrial inner membrane KOG1589 Uncharacterized conserved protein Cluster-16803.0 BF_2 4.00 0.61 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16804.0 BF_2 3.00 0.42 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16804.1 BF_2 3.00 0.71 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16808.0 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16817.0 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16824.0 BF_2 5.00 0.35 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16826.0 BF_2 5.00 0.32 931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16837.0 BF_2 9.00 0.32 1467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16837.1 BF_2 8.00 0.51 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16840.0 BF_2 6.56 0.42 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16847.0 BF_2 1.00 0.72 339 -- -- -- -- -- 768311752 CP010980.1 339 4.99049e-176 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16849.0 BF_2 3.00 0.33 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16853.0 BF_2 1.00 0.37 398 544463100 XP_005567901.1 591 7.6e-59 PREDICTED: immunoglobulin lambda-like polypeptide 5-like isoform X3 [Macaca fascicularis] 186134 M75282.1 362 0 HUMIGLDS Human Ig lambda L chain subgroup II V-2.DS mRNA, VJ region, partial cds >gnl|BL_ORD_ID|38026 Human Ig rearranged lambda chain (V-lambda-2.DS) mRNA, V-, J-, and C-region subgroup II -- -- -- -- P04209 458 8.3e-45 Ig lambda chain V-II region NIG-84 OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16854.0 BF_2 2.00 0.34 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16854.1 BF_2 3.00 1.06 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16857.0 BF_2 3.00 0.39 611 755945738 XP_011299902.1 274 6.7e-22 PREDICTED: leptin receptor overlapping transcript-like 1 isoform X2 [Fopius arisanus]>gi|755945741|ref|XP_011299903.1| PREDICTED: leptin receptor overlapping transcript-like 1 isoform X2 [Fopius arisanus] -- -- -- -- -- -- -- -- -- B3Y064 191 1.2e-13 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-16864.0 BF_2 42.00 5.46 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16866.0 BF_2 1.00 0.39 394 391325047 XP_003737052.1 199 2.1e-13 PREDICTED: uncharacterized protein LOC100897858 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16870.0 BF_2 2.00 0.51 452 499009542 XP_004556988.1 516 4.3e-50 PREDICTED: 40S ribosomal protein S14 [Maylandia zebra] 697090336 XM_009659779.1 420 0 Verticillium dahliae VdLs.17 40S ribosomal protein S14 mRNA K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P19115 534 1.4e-53 40S ribosomal protein S14 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=rps-14 PE=3 SV=2 PF03423//PF00411//PF05853 Carbohydrate binding domain (family 25)//Ribosomal protein S11//3-keto-5-aminohexanoate cleavage enzyme GO:0006412//GO:0042254//GO:0019475 translation//ribosome biogenesis//L-lysine catabolic process to acetate GO:2001070//GO:0016740//GO:0003735 starch binding//transferase activity//structural constituent of ribosome GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-16871.0 BF_2 4.00 0.58 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843 Herpesvirus tegument protein, N-terminal conserved region GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-16879.0 BF_2 8.00 0.52 926 152013691 ABS19961.1 249 8.0e-19 selenoprotein W2 [Artemia franciscana] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08103 Uperin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-16880.0 BF_2 2.00 4.66 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16883.0 BF_2 4.00 0.77 505 554557623 XP_005873227.1 648 2.4e-65 PREDICTED: 60S ribosomal protein L32-like [Myotis brandtii] 694900308 XM_001156825.4 505 0 PREDICTED: Pan troglodytes ribosomal protein L32 (RPL32), mRNA K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 P17932 571 8.3e-58 Putative 60S ribosomal protein L32' OS=Mus musculus GN=Rpl32-ps PE=5 SV=2 PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0878 60S ribosomal protein L32 Cluster-16885.0 BF_2 1.00 0.43 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16899.0 BF_2 3.00 0.33 667 189237914 XP_969710.2 547 1.6e-53 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 755531299 XM_006511704.2 79 3.52284e-31 PREDICTED: Mus musculus protein phosphatase 2, regulatory subunit B'', alpha (Ppp2r3a), transcript variant X1, mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q06190 489 3.5e-48 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens GN=PPP2R3A PE=1 SV=1 PF13202//PF13499//PF10591//PF13833//PF13405//PF00036 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-16907.2 BF_2 3.00 0.46 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00649 Copper fist DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005507//GO:0003677 transcription factor activity, sequence-specific DNA binding//copper ion binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-16914.3 BF_2 24.44 0.52 2241 242008101 XP_002424851.1 316 3.3e-26 Y box binding protein, putative [Pediculus humanus corporis]>gi|212508401|gb|EEB12113.1| Y box binding protein, putative [Pediculus humanus corporis] 385724703 JQ772110.1 477 0 Cherax quadricarinatus cold shock Y-box protein mRNA, complete cds K09276 YBX1, NSEP1 Y-box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09276 P62961 287 3.1e-24 Nuclease-sensitive element-binding protein 1 OS=Rattus norvegicus GN=Ybx1 PE=2 SV=3 PF00313//PF03568 'Cold-shock' DNA-binding domain//Peptidase family C50 GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0003676//GO:0003677//GO:0008233 nucleic acid binding//DNA binding//peptidase activity GO:0005634 nucleus KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-16919.0 BF_2 8.00 0.67 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16927.0 BF_2 24.00 5.64 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16928.0 BF_2 1.00 1.82 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16940.0 BF_2 10.00 1.88 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01664 Reovirus viral attachment protein sigma 1 GO:0007155//GO:0019062//GO:0019058 cell adhesion//virion attachment to host cell//viral life cycle -- -- -- -- -- -- Cluster-16948.0 BF_2 1.00 0.31 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16960.0 BF_2 3.00 0.57 508 637314072 XP_008111426.1 173 2.9e-10 PREDICTED: granulins [Anolis carolinensis] -- -- -- -- -- -- -- -- -- P28799 149 7.2e-09 Granulins OS=Homo sapiens GN=GRN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4296 Epithelin/granulin Cluster-16969.0 BF_2 2.00 0.46 468 350644290 CCD60964.1 246 9.1e-19 60S ribosomal protein L14, putative [Schistosoma mansoni] 631372563 XM_007922471.1 198 1.70757e-97 Pseudocercospora fijiensis CIRAD86 hypothetical protein mRNA K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 P38754 298 3.5e-26 60S ribosomal protein L14-B OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=RPL14B PE=1 SV=1 PF12920//PF01929 TcdA/TcdB pore forming domain//Ribosomal protein L14 GO:0006412//GO:0042254//GO:0009405 translation//ribosome biogenesis//pathogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3421 60S ribosomal protein L14 Cluster-16970.0 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16972.1 BF_2 7.00 0.44 951 240977291 XP_002402670.1 800 1.1e-82 membrane protein, putative [Ixodes scapularis]>gi|215491221|gb|EEC00862.1| membrane protein, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- Q8NBX0 542 3.6e-54 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2733 Uncharacterized membrane protein Cluster-16973.1 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16978.0 BF_2 3.00 0.37 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16980.0 BF_2 7.00 0.41 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16981.0 BF_2 3.00 1.27 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16986.0 BF_2 7.34 0.38 1100 642918551 XP_008198974.1 884 2.2e-92 PREDICTED: fork head domain-containing protein FD2-like [Tribolium castaneum] 701432873 XM_010006257.1 59 7.78368e-20 PREDICTED: Chaetura pelagica forkhead box protein L1-like (LOC104396420), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 Q02360 473 4.2e-46 Fork head domain-containing protein FD2 OS=Drosophila melanogaster GN=fd64A PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-16995.0 BF_2 2.00 0.44 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16997.0 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-16998.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17008.0 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17009.0 BF_2 2.00 0.33 541 148227342 NP_001087172.1 488 9.1e-47 phosphoethanolamine methyltransferase [Xenopus laevis]>gi|50417800|gb|AAH78119.1| MGC83638 protein [Xenopus laevis] -- -- -- -- -- K05929 E2.1.1.103, NMT phosphoethanolamine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05929 Q9C6B9 521 5.6e-52 Phosphoethanolamine N-methyltransferase 3 OS=Arabidopsis thaliana GN=NMT3 PE=2 SV=2 PF03059//PF01209//PF05891//PF09445//PF01795//PF01135//PF05175//PF01728//PF08241//PF08123 Nicotianamine synthase protein//ubiE/COQ5 methyltransferase family//AdoMet dependent proline di-methyltransferase//RNA cap guanine-N2 methyltransferase//MraW methylase family//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//FtsJ-like methyltransferase//Methyltransferase domain//Histone methylation protein DOT1 GO:0006480//GO:0006479//GO:0032259//GO:0006554//GO:0046500//GO:0009452//GO:0006464//GO:0008152//GO:0001510//GO:0030418 N-terminal protein amino acid methylation//protein methylation//methylation//lysine catabolic process//S-adenosylmethionine metabolic process//7-methylguanosine RNA capping//cellular protein modification process//metabolic process//RNA methylation//nicotianamine biosynthetic process GO:0008168//GO:0004719//GO:0030410//GO:0018024 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nicotianamine synthase activity//histone-lysine N-methyltransferase activity -- -- KOG1269 SAM-dependent methyltransferases Cluster-17010.0 BF_2 5.00 0.74 569 805819675 XP_012149959.1 135 8.2e-06 PREDICTED: uncharacterized protein LOC100882345 [Megachile rotundata]>gi|805819677|ref|XP_012149960.1| PREDICTED: uncharacterized protein LOC100882345 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17011.0 BF_2 5.00 0.39 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17012.0 BF_2 6.00 0.40 913 742106223 XP_010870816.1 208 4.5e-14 PREDICTED: hemicentin-1 [Esox lucius] -- -- -- -- -- K17341 HMCN hemicentin http://www.genome.jp/dbget-bin/www_bget?ko:K17341 P97300 202 9.2e-15 Neuroplastin OS=Mus musculus GN=Nptn PE=1 SV=3 PF07354//PF13895 Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain GO:0007339 binding of sperm to zona pellucida GO:0005515 protein binding GO:0005576 extracellular region KOG4475 FOG: Immunoglobin and related proteins Cluster-17015.0 BF_2 2.00 0.40 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17017.0 BF_2 2.00 0.32 552 242002706 XP_002435996.1 221 8.4e-16 sulfotransferase, putative [Ixodes scapularis]>gi|215499332|gb|EEC08826.1| sulfotransferase, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17018.0 BF_2 1.00 1.52 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17020.1 BF_2 1.00 27.15 210 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17032.0 BF_2 3.00 0.51 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-17033.0 BF_2 4.00 0.91 471 759042845 XP_011330282.1 501 2.5e-48 PREDICTED: 60S ribosomal protein L32 [Cerapachys biroi]>gi|607365274|gb|EZA59472.1| 60S ribosomal protein L32 [Cerapachys biroi] -- -- -- -- -- K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q962T1 491 1.5e-48 60S ribosomal protein L32 OS=Spodoptera frugiperda GN=RpL32 PE=2 SV=1 PF07988//PF01655 LMSTEN motif//Ribosomal protein L32 GO:0006355//GO:0042254//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0878 60S ribosomal protein L32 Cluster-17043.0 BF_2 6.00 1.02 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17048.0 BF_2 2.58 1.22 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17052.0 BF_2 6.00 0.37 966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17054.0 BF_2 7.00 0.46 922 91079654 XP_968593.1 392 2.1e-35 PREDICTED: pupal cuticle protein 20 [Tribolium castaneum]>gi|270004478|gb|EFA00926.1| hypothetical protein TcasGA2_TC003832 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 242 2.1e-19 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-17056.0 BF_2 1.00 0.85 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17059.0 BF_2 1.00 0.66 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17071.0 BF_2 15.00 1.41 732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01848//PF08120//PF07503 Hok/gef family//Tamulustoxin family//HypF finger GO:0006810//GO:0009405 transport//pathogenesis GO:0019870//GO:0008270 potassium channel inhibitor activity//zinc ion binding GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-17075.0 BF_2 1.00 0.39 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17081.0 BF_2 1.00 0.39 392 91088839 XP_970745.1 212 6.6e-15 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] -- -- -- -- -- K13189 RBM14 RNA-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13189 Q94901 180 1.4e-12 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0097159//GO:0043169//GO:0003676//GO:1901363 organic cyclic compound binding//cation binding//nucleic acid binding//heterocyclic compound binding -- -- -- -- Cluster-17082.0 BF_2 7.00 0.57 800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00839 Cysteine rich repeat -- -- -- -- GO:0016020 membrane -- -- Cluster-17084.0 BF_2 1.34 0.45 410 642920073 XP_008192195.1 453 7.9e-43 PREDICTED: ammonium transporter Rh type A [Tribolium castaneum] -- -- -- -- -- K06580 SLC42A, RHAG, RHBG, RHCG ammonium transporter Rh http://www.genome.jp/dbget-bin/www_bget?ko:K06580 Q69D48 316 2.5e-28 Ammonium transporter Rh type B-A OS=Xenopus laevis GN=rhbg-a PE=2 SV=1 PF00909 Ammonium Transporter Family GO:0015696 ammonium transport GO:0008519 ammonium transmembrane transporter activity GO:0016020 membrane KOG3796 Ammonium transporter RHBG Cluster-17089.0 BF_2 2.00 0.51 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17090.0 BF_2 12.00 1.30 674 642127922 CDQ59834.1 257 6.9e-20 unnamed protein product [Oncorhynchus mykiss] 21284371 U92652.2 142 3.38971e-66 BOU92652 Brassica oleracea var. botrytis tonoplast intrinsic protein bobTIP26-2 mRNA, partial cds K09869 AQP8 aquaporin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K09869 P50156 629 2.1e-64 Probable aquaporin TIP1-1 OS=Oryza sativa subsp. japonica GN=TIP1-1 PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-17093.0 BF_2 7.00 1.28 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17094.0 BF_2 2.00 0.31 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17099.0 BF_2 4.00 0.52 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17099.1 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17099.2 BF_2 3.00 0.86 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17102.0 BF_2 5.00 0.71 581 391347623 XP_003748059.1 736 1.7e-75 PREDICTED: bifunctional purine biosynthesis protein PURH-like [Metaseiulus occidentalis] -- -- -- -- -- K00602 purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K00602 P31335 621 1.5e-63 Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1 PF01808 AICARFT/IMPCHase bienzyme GO:0006164//GO:0006807//GO:0006144 purine nucleotide biosynthetic process//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0004643//GO:0003937 phosphoribosylaminoimidazolecarboxamide formyltransferase activity//IMP cyclohydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG2555 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase Cluster-17111.0 BF_2 2.00 1.14 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17112.0 BF_2 13.00 0.60 1199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17114.0 BF_2 4.00 0.36 756 270015858 EFA12306.1 141 2.2e-06 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02055 O-Glycosyl hydrolase family 30 GO:0005975//GO:0006687//GO:0006807//GO:0006665 carbohydrate metabolic process//glycosphingolipid metabolic process//nitrogen compound metabolic process//sphingolipid metabolic process GO:0004348 glucosylceramidase activity -- -- -- -- Cluster-17115.0 BF_2 4.00 0.62 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17125.0 BF_2 11.00 0.59 1066 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17125.1 BF_2 22.60 0.34 3084 642932840 XP_008197008.1 1667 1.0e-182 PREDICTED: uncharacterized protein LOC103314036 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-17127.0 BF_2 2.00 1.24 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17131.0 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17139.0 BF_2 18.00 1.10 971 291222349 XP_002731171.1 797 2.4e-82 PREDICTED: 60S ribosomal protein L4-B-like [Saccoglossus kowalevskii] -- -- -- -- -- K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P08429 769 1.7e-80 60S ribosomal protein L4-A OS=Xenopus laevis GN=rpl4-a PE=2 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-17139.1 BF_2 3.00 0.46 558 675385717 KFM78614.1 555 1.6e-54 60S ribosomal protein L4, partial [Stegodyphus mimosarum] -- -- -- -- -- K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P02385 511 8.3e-51 60S ribosomal protein L4-B OS=Xenopus laevis GN=rpl4-b PE=2 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-17142.0 BF_2 8.00 0.45 1026 307187010 EFN72328.1 206 8.6e-14 Histone-lysine N-methyltransferase SETMAR, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17157.0 BF_2 8.00 1.51 508 149286948 ABR23373.1 598 1.5e-59 40S ribosomal protein S14 [Ornithodoros parkeri] 389610700 AK402340.1 156 4.15198e-74 Papilio polytes mRNA for ribosomal protein S14a, complete cds, sequence id: Pp-0096 K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 Q08699 550 2.3e-55 40S ribosomal protein S14 OS=Podocoryne carnea GN=RPS14 PE=2 SV=1 PF00411//PF03423 Ribosomal protein S11//Carbohydrate binding domain (family 25) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-17161.0 BF_2 1.00 0.44 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03153//PF02166//PF12090//PF01080 Transcription factor IIA, alpha/beta subunit//Androgen receptor//Spt20 family//Presenilin GO:0007165//GO:0006367//GO:0006355//GO:0030521 signal transduction//transcription initiation from RNA polymerase II promoter//regulation of transcription, DNA-templated//androgen receptor signaling pathway GO:0004882//GO:0003677//GO:0004190//GO:0005496//GO:0003712 androgen receptor activity//DNA binding//aspartic-type endopeptidase activity//steroid binding//transcription cofactor activity GO:0000124//GO:0005667//GO:0016021//GO:0005634//GO:0005672 SAGA complex//transcription factor complex//integral component of membrane//nucleus//transcription factor TFIIA complex -- -- Cluster-17163.0 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17164.1 BF_2 3.00 1.15 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17165.0 BF_2 3.00 0.41 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17166.0 BF_2 55.00 3.04 1044 675887198 XP_009029101.1 725 5.8e-74 hypothetical protein HELRODRAFT_185163 [Helobdella robusta]>gi|555689570|gb|ESN92802.1| hypothetical protein HELRODRAFT_185163 [Helobdella robusta] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 689 3.6e-71 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-17170.0 BF_2 6.00 0.51 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17171.0 BF_2 5.00 2.25 378 322793851 EFZ17191.1 217 1.7e-15 hypothetical protein SINV_15085, partial [Solenopsis invicta] -- -- -- -- -- K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 Q95Y04 209 5.9e-16 40S ribosomal protein S28 OS=Caenorhabditis elegans GN=rps-28 PE=3 SV=1 PF01200 Ribosomal protein S28e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-17173.0 BF_2 9.00 1.35 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17174.0 BF_2 12.00 1.27 682 553832075 AGY61444.1 222 8.0e-16 30S ribosomal protein S19 [Lotharella sp. CCMP622] 761231940 KM881643.1 670 0 Oryza officinalis chloroplast, complete genome -- -- -- -- P12153 477 8.9e-47 30S ribosomal protein S19, chloroplastic OS=Oryza sativa subsp. japonica GN=rps19-A PE=3 SV=3 PF00203//PF03947 Ribosomal protein S19//Ribosomal Proteins L2, C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0899 Mitochondrial/chloroplast ribosomal protein S19 Cluster-17174.1 BF_2 2.00 0.72 403 -- -- -- -- -- 761231856 KM881642.1 403 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C444 648 7.8e-67 50S ribosomal protein L22, chloroplastic OS=Oryza sativa GN=rpl22 PE=3 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-17177.0 BF_2 4.00 2.51 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17186.0 BF_2 2.00 0.31 555 512926542 XP_004931111.1 246 1.1e-18 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial-like [Bombyx mori] -- -- -- -- -- K03958 NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03958 Q0MQC7 195 3.6e-14 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial OS=Pongo pygmaeus GN=NDUFB2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17202.0 BF_2 10.00 0.69 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17210.0 BF_2 6.00 0.72 638 325302926 DAA34494.1 305 1.8e-25 TPA_inf: ATP synthase c-subunit [Amblyomma variegatum] 751440757 XM_011193111.1 93 5.54586e-39 PREDICTED: Bactrocera cucurbitae ATP synthase lipid-binding protein, mitochondrial (LOC105217866), transcript variant X2, mRNA K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 P48201 209 9.9e-16 ATP synthase F(0) complex subunit C3, mitochondrial OS=Homo sapiens GN=ATP5G3 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-17213.0 BF_2 2.00 0.69 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17215.0 BF_2 7.00 0.40 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17215.3 BF_2 11.00 0.31 1786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17216.0 BF_2 4.12 0.35 783 158286603 XP_308831.4 223 7.0e-16 AGAP006931-PA [Anopheles gambiae str. PEST]>gi|157020547|gb|EAA04403.4| AGAP006931-PA [Anopheles gambiae str. PEST] 121484217 EF102012.1 437 0 Portunus pelagicus cuticle protein CB7-like mRNA, complete sequence -- -- -- -- P82119 180 2.8e-12 Cuticle protein 6 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-17224.0 BF_2 2.00 0.55 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17225.1 BF_2 7.00 0.42 989 642928982 XP_972386.2 857 2.7e-89 PREDICTED: myrosinase 1-like [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 734 2.0e-76 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-17233.0 BF_2 4.00 0.74 512 -- -- -- -- -- 761231856 KM881642.1 512 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- Q09G52 161 2.9e-10 Photosystem II reaction center protein M OS=Platanus occidentalis GN=psbM PE=3 SV=1 PF05151//PF06596 Photosystem II reaction centre M protein (PsbM)//Photosystem II reaction centre X protein (PsbX) GO:0019684//GO:0015979 photosynthesis, light reaction//photosynthesis -- -- GO:0009523//GO:0016020//GO:0016021 photosystem II//membrane//integral component of membrane -- -- Cluster-17238.0 BF_2 26.00 1.20 1193 484759869 YP_007890478.1 245 3.0e-18 ribosomal protein S7 (mitochondrion) [Andalucia godoyi]>gi|462269100|gb|AGH23972.1| ribosomal protein S7 (mitochondrion) [Andalucia godoyi] 110287586 DQ645537.1 761 0 Zea luxurians mitochondrion, complete genome -- -- -- -- Q01902 752 2.0e-78 Ribosomal protein S7, mitochondrial OS=Triticum aestivum GN=RPS7 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-17243.0 BF_2 13.12 1.77 597 332376071 AEE63176.1 438 6.3e-41 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q60534 220 4.9e-17 Androgen-dependent TFPI-regulating protein OS=Mesocricetus auratus GN=ADTRP PE=2 SV=1 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-17245.2 BF_2 3.00 0.44 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17254.0 BF_2 5.00 0.47 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17267.0 BF_2 14.00 1.39 708 82795521 ABB91674.1 884 1.4e-92 calcified cuticle protein CP19.0 isoform A [Callinectes sapidus] 82795520 DQ288149.1 465 0 Callinectes sapidus calcified cuticle protein CP19.0 isoform A mRNA, complete cds -- -- -- -- P81584 437 4.0e-42 Cuticle protein CP1876 OS=Cancer pagurus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17268.0 BF_2 2.00 0.53 446 694846169 XP_009464099.1 218 1.5e-15 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B [Nipponia nippon] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 O95263 203 3.4e-15 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Homo sapiens GN=PDE8B PE=1 SV=2 PF00989//PF08447 PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-17269.0 BF_2 12.00 0.98 797 307141004 ADN34300.1 570 4.2e-56 myosin alkali light chain protein [Haemaphysalis longicornis] -- -- -- -- -- K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 P06742 400 8.8e-38 Myosin light chain alkali OS=Drosophila melanogaster GN=Mlc1 PE=1 SV=4 PF00036//PF13405//PF13499 EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-17271.0 BF_2 3.00 0.58 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17280.0 BF_2 19.84 0.37 2543 449139004 AGE89831.1 657 1.1e-65 isoprenyl diphosphate synthase [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- P08836 482 8.7e-47 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-17291.0 BF_2 3.00 0.37 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17293.0 BF_2 10.00 0.82 800 -- -- -- -- -- 761231856 KM881642.1 800 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17294.0 BF_2 7.00 0.43 965 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17295.0 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001//PF03604 7 transmembrane receptor (rhodopsin family)//DNA directed RNA polymerase, 7 kDa subunit GO:0006144//GO:0006351//GO:0007186//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//G-protein coupled receptor signaling pathway//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0004930 DNA-directed RNA polymerase activity//DNA binding//G-protein coupled receptor activity GO:0016021//GO:0005730 integral component of membrane//nucleolus -- -- Cluster-17297.0 BF_2 1.00 0.42 385 -- -- -- -- -- 41367337 BX664711.2 385 0 Oryza sativa chromosome 12, . BAC B1001E08 of chromosome 12 of cultivar Nipponbare of ssp. japonica of Oryza sativa (rice), complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17298.0 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17306.0 BF_2 3.00 1.28 383 391333957 XP_003741376.1 192 1.3e-12 PREDICTED: cathepsin S-like [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q86GF7 143 2.7e-08 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17314.0 BF_2 8.32 0.56 909 642929436 XP_008195839.1 339 2.9e-29 PREDICTED: probable E3 ubiquitin-protein ligase sinah [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus -- -- Cluster-17323.0 BF_2 3.00 0.55 516 318087278 ADV40231.1 279 1.5e-22 putative ribosome-attached membrane protein 4 [Latrodectus hesperus] 67084012 DQ066304.1 58 1.26582e-19 Ixodes scapularis isolate IS-6-12L-87 ribosome associated membrane protein 4 mRNA, complete cds -- -- -- -- Q3T073 260 9.8e-22 Stress-associated endoplasmic reticulum protein 2 OS=Bos taurus GN=SERP2 PE=3 SV=1 PF06624 Ribosome associated membrane protein RAMP4 -- -- -- -- GO:0005783 endoplasmic reticulum KOG3491 Predicted membrane protein Cluster-17326.0 BF_2 11.00 0.49 1222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17327.0 BF_2 3.00 0.87 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17328.0 BF_2 4.00 0.74 513 309242901 BAJ22990.1 443 1.4e-41 cytochrome c [Marsupenaeus japonicus] 260819615 XM_002605086.1 70 2.68471e-26 Branchiostoma floridae hypothetical protein, mRNA K08738 CYC cytochrome c http://www.genome.jp/dbget-bin/www_bget?ko:K08738 P00040 405 1.5e-38 Cytochrome c OS=Schistocerca gregaria PE=1 SV=2 PF00034//PF13442 Cytochrome c//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- KOG3453 Cytochrome c Cluster-17337.1 BF_2 2.00 7.05 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17337.4 BF_2 3.00 0.93 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17338.0 BF_2 3.00 0.36 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17342.0 BF_2 4.00 0.40 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17346.0 BF_2 2.00 0.47 464 542252653 XP_005462277.1 617 8.6e-62 PREDICTED: acetyl-coenzyme A synthetase 2-like, mitochondrial-like [Oreochromis niloticus] -- -- -- -- -- K01895 ACSS, acs acetyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01895 Q99NB1 568 1.7e-57 Acetyl-coenzyme A synthetase 2-like, mitochondrial OS=Mus musculus GN=Acss1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-17347.0 BF_2 3.00 0.35 649 91083977 XP_975169.1 223 5.8e-16 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 [Tribolium castaneum]>gi|270008257|gb|EFA04705.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa [Tribolium castaneum] -- -- -- -- -- K03951 NDUFA7 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03951 Q9Z1P6 126 4.2e-06 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 OS=Mus musculus GN=Ndufa7 PE=1 SV=3 PF07347 NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) GO:0015992//GO:0042773//GO:0006814//GO:0006120//GO:0006744 proton transport//ATP synthesis coupled electron transport//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane -- -- Cluster-17351.0 BF_2 11.00 0.52 1165 391327862 XP_003738414.1 1354 7.5e-147 PREDICTED: guanine nucleotide-binding protein subunit beta-2-like 1-like [Metaseiulus occidentalis] 185135456 NM_001124668.1 135 4.65804e-62 Oncorhynchus mykiss RACK1 (LOC100136700), mRNA >gnl|BL_ORD_ID|4884340 Oncorhynchus mykiss RACK1 mRNA, complete cds K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1309 5.1e-143 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-17360.0 BF_2 5.00 0.66 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17362.0 BF_2 4.00 1.11 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17365.0 BF_2 3.00 1.89 349 532010415 XP_005349008.1 188 3.6e-12 PREDICTED: epoxide hydrolase 1 isoform X1 [Microtus ochrogaster] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 P79381 184 4.3e-13 Epoxide hydrolase 1 OS=Sus scrofa GN=EPHX1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-17371.0 BF_2 9.02 0.39 1251 189237943 XP_001811459.1 771 3.2e-79 PREDICTED: WD repeat domain-containing protein 83 [Tribolium castaneum] -- -- -- -- -- K13124 MORG1 mitogen-activated protein kinase organizer 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13124 Q5BLX8 552 3.3e-55 WD repeat domain-containing protein 83 OS=Rattus norvegicus GN=Wdr83 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0316 Conserved WD40 repeat-containing protein Cluster-17374.0 BF_2 2.00 0.38 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17377.0 BF_2 1.00 0.60 352 817061854 XP_012252550.1 446 4.4e-42 PREDICTED: uncharacterized protein LOC105684035 [Athalia rosae] 338224504 HM217904.1 130 7.91904e-60 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- Q6PCB5 337 7.9e-31 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-17379.0 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17390.0 BF_2 7.00 0.74 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17392.0 BF_2 1.00 15.15 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17392.1 BF_2 2.00 0.75 398 642939904 XP_008200270.1 208 2.0e-14 PREDICTED: general odorant-binding protein 28a [Tribolium castaneum]>gi|270015618|gb|EFA12066.1| odorant binding protein 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-17404.0 BF_2 7.00 1.35 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17405.0 BF_2 1.00 0.77 335 719769482 XP_010218741.1 247 4.9e-19 PREDICTED: LOW QUALITY PROTEIN: KRAB-A domain-containing protein 2, partial [Tinamus guttatus] 90265081 AL442108.2 320 1.79668e-165 Oryza sativa genomic DNA, chromosome 4, BAC clone: H0124E07, complete sequence -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-17412.0 BF_2 5.00 0.44 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17414.0 BF_2 3.00 0.97 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17415.0 BF_2 10.00 0.38 1384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17421.0 BF_2 39.00 0.97 1964 642927986 XP_008195473.1 1049 2.9e-111 PREDICTED: uncharacterized protein LOC103313592 [Tribolium castaneum]>gi|270010273|gb|EFA06721.1| hypothetical protein TcasGA2_TC009652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17422.1 BF_2 2.00 0.60 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17423.0 BF_2 1.00 0.62 350 -- -- -- -- -- 768053410 XM_011548266.1 337 6.68767e-175 PREDICTED: Homo sapiens TAP binding protein (tapasin) (TAPBP), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF05733 Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0003723 RNA binding GO:0019013 viral nucleocapsid -- -- Cluster-17424.0 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17431.0 BF_2 7.00 0.58 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17436.0 BF_2 4.00 0.62 557 344298281 XP_003420822.1 604 3.3e-60 PREDICTED: 40S ribosomal protein S16 [Loxodonta africana] 195487907 XM_002092056.1 90 2.23421e-37 Drosophila yakuba GE13998 (Dyak\GE13998), partial mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 Q98TR7 595 1.5e-60 40S ribosomal protein S16 OS=Heteropneustes fossilis GN=rps16 PE=2 SV=1 PF00380 Ribosomal protein S9/S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-17444.0 BF_2 4.00 1.30 415 195969732 ACG60661.1 480 5.9e-46 hypothetical protein [Macrobrachium rosenbergii] -- -- -- -- -- K02130 ATPeF0F, ATP5J2 F-type H+-transporting ATPase subunit f http://www.genome.jp/dbget-bin/www_bget?ko:K02130 Q9W141 426 4.4e-41 Putative ATP synthase subunit f, mitochondrial OS=Drosophila melanogaster GN=CG4692 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-17447.0 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17453.0 BF_2 3.00 2.16 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17459.0 BF_2 3.00 0.76 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17465.0 BF_2 2.00 0.49 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16497 MHC-I family domain GO:0006955 immune response -- -- -- -- -- -- Cluster-17482.0 BF_2 5.00 0.44 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17484.0 BF_2 8.00 0.39 1144 646722936 KDR23730.1 264 1.8e-20 Nucleosome assembly protein 1-like 4 [Zootermopsis nevadensis] 597761908 XM_007244869.1 56 3.77087e-18 PREDICTED: Astyanax mexicanus nucleosome assembly protein 1-like 4-like (LOC103028024), transcript variant X4, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 Q7ZY81 222 5.5e-17 Nucleosome assembly protein 1-like 1-B OS=Xenopus laevis GN=nap1l1-b PE=1 SV=1 PF00956 Nucleosome assembly protein (NAP) GO:0006334 nucleosome assembly -- -- GO:0005634 nucleus -- -- Cluster-17491.0 BF_2 5.00 0.33 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17493.0 BF_2 3.00 0.32 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17503.0 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17513.1 BF_2 1.00 0.60 352 -- -- -- -- -- 262401328 FJ774846.1 135 1.31579e-62 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17514.0 BF_2 8.00 0.53 918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17517.1 BF_2 3.00 0.37 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-17518.0 BF_2 8.00 0.36 1220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17524.0 BF_2 4.00 0.49 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17529.0 BF_2 6.00 0.34 1023 820805564 AKG92773.1 1586 8.2e-174 single minded [Leptinotarsa decemlineata] 642937557 XM_962837.3 275 6.09377e-140 PREDICTED: Tribolium castaneum single-minded homolog 1 (LOC656297), transcript variant X3, mRNA K09100 SIM single-minded http://www.genome.jp/dbget-bin/www_bget?ko:K09100 Q61045 1262 1.3e-137 Single-minded homolog 1 OS=Mus musculus GN=Sim1 PE=1 SV=3 PF00989//PF12899//PF00010//PF08447 PAS fold//Alkaline and neutral invertase//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0033926//GO:0046983//GO:0005515 glycopeptide alpha-N-acetylgalactosaminidase activity//protein dimerization activity//protein binding -- -- -- -- Cluster-17542.0 BF_2 3.00 0.48 551 806629189 AKB96198.1 782 7.5e-81 heat shock protein [Cherax destructor] 224552884 FJ646615.1 158 3.49238e-75 Scylla paramamosain heat shock protein 20.6 isoform 2 mRNA, partial cds -- -- -- -- P30219 154 2.0e-09 Heat shock protein 30D OS=Xenopus laevis GN=hsp30d PE=3 SV=1 PF07352 Bacteriophage Mu Gam like protein GO:0042262 DNA protection GO:0003690 double-stranded DNA binding -- -- KOG3591 Alpha crystallins Cluster-17543.0 BF_2 15.17 0.82 1058 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17544.0 BF_2 9.00 0.36 1322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17553.0 BF_2 1.00 1.52 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17555.0 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17558.0 BF_2 10.00 0.48 1157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17561.0 BF_2 2.00 0.34 536 734562182 KHN88128.1 197 5.0e-13 Proton myo-inositol cotransporter [Toxocara canis] -- -- -- -- -- -- -- -- -- P32465 289 4.4e-25 Low-affinity glucose transporter HXT1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=HXT1 PE=1 SV=1 PF00083//PF07690//PF03092 Sugar (and other) transporter//Major Facilitator Superfamily//BT1 family GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-17563.0 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17567.0 BF_2 2.00 0.81 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17571.0 BF_2 7.00 1.01 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17572.0 BF_2 3.65 0.90 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17574.0 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17577.0 BF_2 106.72 2.82 1870 796536107 AKA60071.1 2246 4.4e-250 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (chloroplast) [Picomonas sp. DN1] 761231605 KM881639.1 1870 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P48718 2335 8.7e-262 Ribulose bisphosphate carboxylase large chain OS=Viscum album GN=rbcL PE=3 SV=1 PF00016//PF02788 Ribulose bisphosphate carboxylase large chain, catalytic domain//Ribulose bisphosphate carboxylase large chain, N-terminal domain GO:0015977//GO:0046487 carbon fixation//glyoxylate metabolic process GO:0000287//GO:0016984 magnesium ion binding//ribulose-bisphosphate carboxylase activity GO:0009573 chloroplast ribulose bisphosphate carboxylase complex -- -- Cluster-17577.1 BF_2 6.00 0.94 553 796536107 AKA60071.1 866 1.4e-90 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (chloroplast) [Picomonas sp. DN1] 597569085 KF990036.1 529 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- P28387 945 3.9e-101 Ribulose bisphosphate carboxylase large chain (Fragment) OS=Byrsonima crassifolia GN=rbcL PE=3 SV=1 PF00016 Ribulose bisphosphate carboxylase large chain, catalytic domain -- -- GO:0000287 magnesium ion binding -- -- -- -- Cluster-17577.3 BF_2 13.28 0.63 1171 796536107 AKA60071.1 1255 2.3e-135 ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit (chloroplast) [Picomonas sp. DN1] 761231605 KM881639.1 988 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q01873 1356 1.8e-148 Ribulose bisphosphate carboxylase large chain OS=Liquidambar styraciflua GN=rbcL PE=3 SV=1 PF02788//PF00016 Ribulose bisphosphate carboxylase large chain, N-terminal domain//Ribulose bisphosphate carboxylase large chain, catalytic domain GO:0046487//GO:0015977 glyoxylate metabolic process//carbon fixation GO:0016984//GO:0000287 ribulose-bisphosphate carboxylase activity//magnesium ion binding GO:0009573 chloroplast ribulose bisphosphate carboxylase complex -- -- Cluster-17578.0 BF_2 2.00 1.07 362 325303378 DAA34089.1 221 5.5e-16 TPA_exp: ubiquinol cytochrome C reductase subunit RIP1 [Amblyomma variegatum] -- -- -- -- -- -- -- -- -- P13272 129 1.1e-06 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Bos taurus GN=UQCRFS1 PE=1 SV=3 PF02921//PF09165 Ubiquinol cytochrome reductase transmembrane region//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal GO:0006118//GO:0055114//GO:0015992//GO:0006119 obsolete electron transport//oxidation-reduction process//proton transport//oxidative phosphorylation GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-17581.0 BF_2 3.00 0.59 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17591.0 BF_2 6.14 0.31 1104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17593.0 BF_2 4.00 0.50 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17595.0 BF_2 34.70 2.50 867 91076754 XP_973519.1 558 1.1e-54 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66KG0 124 9.7e-06 Solute carrier family 22 member 16 OS=Xenopus laevis GN=slc22a16 PE=2 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-17596.0 BF_2 1.00 0.74 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17614.2 BF_2 12.58 0.66 1088 356984433 AET43964.1 518 6.1e-50 glutathione peroxidase, partial [Reishia clavigera] 488569205 XM_004474165.1 36 4.69784e-07 PREDICTED: Dasypus novemcinctus epididymal secretory glutathione peroxidase-like (LOC101416117), mRNA K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 Q4AEH4 421 4.4e-40 Glutathione peroxidase 3 OS=Macaca fuscata fuscata GN=GPX3 PE=2 SV=2 PF00255 Glutathione peroxidase GO:0006749//GO:0006979//GO:0006804//GO:0055114 glutathione metabolic process//response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-17615.0 BF_2 3.00 0.48 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17617.0 BF_2 3.00 0.49 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17619.0 BF_2 10.00 0.59 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17629.0 BF_2 2.00 0.64 417 675368218 KFM61120.1 632 1.4e-63 Transitional endoplasmic reticulum ATPase TER94, partial [Stegodyphus mimosarum] 152205933 AB248089.1 184 9.13647e-90 Haemaphysalis longicornis VCP gene for valosin containing protein, complete cds K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7ZU99 584 2.1e-59 Transitional endoplasmic reticulum ATPase OS=Danio rerio GN=vcp PE=1 SV=1 PF01695//PF07728//PF01057//PF05496//PF00158//PF06068//PF00004//PF00437//PF00005//PF01637//PF02562//PF02367//PF00910//PF00931//PF10662 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//ABC transporter//Archaeal ATPase//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase//NB-ARC domain//Ethanolamine utilisation - propanediol utilisation GO:0006355//GO:0019079//GO:0006810//GO:0006281//GO:0002949//GO:0006310//GO:0006576 regulation of transcription, DNA-templated//viral genome replication//transport//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//cellular biogenic amine metabolic process GO:0016887//GO:0005524//GO:0008134//GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0043531 ATPase activity//ATP binding//transcription factor binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//ADP binding GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0730 AAA+-type ATPase Cluster-17638.0 BF_2 4.00 0.54 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-17641.0 BF_2 4.00 2.58 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17643.0 BF_2 3.00 1.08 402 -- -- -- -- -- 768001687 XM_011527860.1 402 0 PREDICTED: Homo sapiens histocompatibility (minor) HA-1 (HMHA1), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17651.0 BF_2 13.00 0.79 979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17654.0 BF_2 28.00 5.03 520 820153214 KKX17101.1 347 2.0e-30 60S ribosomal protein L14-like [Scleropages formosus] -- -- -- -- -- K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 Q3T0U2 331 5.8e-30 60S ribosomal protein L14 OS=Bos taurus GN=RPL14 PE=2 SV=3 PF01708//PF01929 Geminivirus putative movement protein//Ribosomal protein L14 GO:0042254//GO:0006412//GO:0046740 ribosome biogenesis//translation//transport of virus in host, cell to cell GO:0003735 structural constituent of ribosome GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular KOG3421 60S ribosomal protein L14 Cluster-17657.0 BF_2 5.00 0.85 532 241999434 XP_002434360.1 456 4.6e-43 3 hydroxysteroid dehydrogenase, putative [Ixodes scapularis]>gi|215497690|gb|EEC07184.1| 3 hydroxysteroid dehydrogenase, putative [Ixodes scapularis] -- -- -- -- -- K12408 HSD3B7 cholest-5-ene-3beta,7alpha-diol 3beta-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K12408 Q9EQC1 206 1.8e-15 3 beta-hydroxysteroid dehydrogenase type 7 OS=Mus musculus GN=Hsd3b7 PE=2 SV=1 PF00056//PF01370//PF03435//PF11698//PF01113//PF00106//PF01073//PF01118 lactate/malate dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//V-ATPase subunit H//Dihydrodipicolinate reductase, N-terminus//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0015991//GO:0008210//GO:0008152//GO:0009085//GO:0009089//GO:0008209//GO:0055114//GO:0006694//GO:0008207 ATP hydrolysis coupled proton transport//estrogen metabolic process//metabolic process//lysine biosynthetic process//lysine biosynthetic process via diaminopimelate//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0016491//GO:0016820//GO:0051287//GO:0004769//GO:0003824//GO:0016616//GO:0008839//GO:0050662//GO:0003854//GO:0016620//GO:0000166 oxidoreductase activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//NAD binding//steroid delta-isomerase activity//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//4-hydroxy-tetrahydrodipicolinate reductase//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//nucleotide binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain KOG1430 C-3 sterol dehydrogenase/3-beta-hydroxysteroid dehydrogenase and related dehydrogenases Cluster-17658.0 BF_2 2.00 0.40 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17660.0 BF_2 6.00 0.36 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17669.0 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17669.1 BF_2 7.00 0.52 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17670.0 BF_2 33.00 0.55 2786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08451 Adenosine/AMP deaminase N-terminal -- -- -- -- GO:0005615 extracellular space -- -- Cluster-17685.0 BF_2 4.00 0.38 724 635071246 XP_008004460.1 349 1.6e-30 PREDICTED: 60S ribosomal protein L35 [Chlorocebus sabaeus] 697067830 XM_009650805.1 716 0 Verticillium dahliae VdLs.17 60S ribosomal protein L35 mRNA K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 Q8L805 493 1.3e-48 60S ribosomal protein L35 OS=Triticum aestivum GN=RPL35 PE=1 SV=1 PF00831 Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3436 60S ribosomal protein L35 Cluster-17692.0 BF_2 16.00 3.26 492 704559326 XP_010182219.1 154 4.4e-08 PREDICTED: cystatin-like [Mesitornis unicolor] -- -- -- -- -- -- -- -- -- P81061 131 8.4e-07 Cystatin OS=Coturnix coturnix japonica PE=1 SV=1 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-17697.0 BF_2 1.00 0.36 403 291239644 XP_002739731.1 183 1.6e-11 PREDICTED: KAT8 regulatory NSL complex subunit 2-like isoform X1 [Saccoglossus kowalevskii]>gi|585699347|ref|XP_006822745.1| PREDICTED: KAT8 regulatory NSL complex subunit 2-like isoform X2 [Saccoglossus kowalevskii]>gi|585699351|ref|XP_006822746.1| PREDICTED: KAT8 regulatory NSL complex subunit 2-like isoform X3 [Saccoglossus kowalevskii]>gi|585699355|ref|XP_006822747.1| PREDICTED: KAT8 regulatory NSL complex subunit 2-like isoform X4 [Saccoglossus kowalevskii] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17702.0 BF_2 14.31 0.35 1981 642925822 XP_008190442.1 400 5.3e-36 PREDICTED: uncharacterized protein LOC103312193 [Tribolium castaneum]>gi|270008612|gb|EFA05060.1| hypothetical protein TcasGA2_TC015155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BXJ7 200 3.4e-14 Protein amnionless OS=Homo sapiens GN=AMN PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-17704.0 BF_2 6.00 0.38 953 283468916 CAP53894.1 193 2.6e-12 histone H1 [Xenoturbella bocki] -- -- -- -- -- -- -- -- -- Q05831 143 6.7e-08 Sperm-specific protein PHI-2B/PHI-3 OS=Mytilus trossulus PE=1 SV=2 PF11081//PF00538//PF07941//PF01080 Protein of unknown function (DUF2890)//linker histone H1 and H5 family//Potassium channel Kv1.4 tandem inactivation domain//Presenilin GO:0006334//GO:0016032//GO:0006813 nucleosome assembly//viral process//potassium ion transport GO:0005249//GO:0003677//GO:0004190//GO:0030955 voltage-gated potassium channel activity//DNA binding//aspartic-type endopeptidase activity//potassium ion binding GO:0008076//GO:0000786//GO:0016021//GO:0005634 voltage-gated potassium channel complex//nucleosome//integral component of membrane//nucleus -- -- Cluster-17706.0 BF_2 6.00 0.31 1104 827545097 XP_012545128.1 139 5.5e-06 PREDICTED: transposable element Tcb1 transposase [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17708.0 BF_2 2.00 0.44 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17710.0 BF_2 4.00 0.93 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17715.0 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17721.0 BF_2 2.88 0.61 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1773.1 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17730.1 BF_2 1.00 1.96 286 641789187 XP_008176438.1 366 6.7e-33 PREDICTED: uncharacterized protein LOC101939727 [Chrysemys picta bellii] 58652042 AP008245.2 274 5.60846e-140 Oryza sativa Japonica Group genomic DNA, chromosome 9, BAC clone:OSJNBb0013K10 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17735.0 BF_2 8.00 0.37 1194 478262752 ENN81283.1 813 4.1e-84 hypothetical protein YQE_02319, partial [Dendroctonus ponderosae]>gi|546680909|gb|ERL91083.1| hypothetical protein D910_08425 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6UWB4 267 3.5e-22 Serine protease 55 OS=Homo sapiens GN=PRSS55 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-17744.0 BF_2 2.00 0.77 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17745.0 BF_2 2.00 0.64 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17748.0 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17751.0 BF_2 10.00 0.72 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17755.0 BF_2 5.00 0.34 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17756.0 BF_2 2.00 0.40 497 817056165 XP_012268929.1 356 1.7e-31 PREDICTED: ileal sodium/bile acid cotransporter-like [Athalia rosae]>gi|817056167|ref|XP_012268930.1| PREDICTED: ileal sodium/bile acid cotransporter-like [Athalia rosae]>gi|817056169|ref|XP_012268931.1| PREDICTED: ileal sodium/bile acid cotransporter-like [Athalia rosae] -- -- -- -- -- -- -- -- -- Q12908 190 1.2e-13 Ileal sodium/bile acid cotransporter OS=Homo sapiens GN=SLC10A2 PE=1 SV=2 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-17757.0 BF_2 7.00 0.31 1246 391338271 XP_003743483.1 1128 1.3e-120 PREDICTED: protein NDRG3-like [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q9UGV2 540 8.0e-54 Protein NDRG3 OS=Homo sapiens GN=NDRG3 PE=1 SV=2 PF02064 MAS20 protein import receptor GO:0006605//GO:0006886 protein targeting//intracellular protein transport -- -- GO:0005742 mitochondrial outer membrane translocase complex KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-17762.0 BF_2 1.00 0.42 386 383853588 XP_003702304.1 153 4.5e-08 PREDICTED: vascular endothelial growth factor C [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-17770.0 BF_2 3.00 0.57 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17772.0 BF_2 4.00 0.51 614 646714831 KDR18664.1 256 8.2e-20 Myocyte-specific enhancer factor 2 [Zootermopsis nevadensis] -- -- -- -- -- K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 178 3.7e-12 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-17774.0 BF_2 3.00 0.36 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17775.0 BF_2 5.00 0.81 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17782.0 BF_2 27.00 23.41 327 509391552 AGN29583.1 454 4.8e-43 ribosomal protein L37 [Acartia pacifica] 260821453 XM_002606002.1 50 2.16264e-15 Branchiostoma floridae hypothetical protein, mRNA K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q9VXX8 420 1.7e-40 Probable 60S ribosomal protein L37-A OS=Drosophila melanogaster GN=RpL37a PE=1 SV=1 PF01155//PF01907//PF01641 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Ribosomal protein L37e//SelR domain GO:0055114//GO:0042254//GO:0006464//GO:0006412 oxidation-reduction process//ribosome biogenesis//cellular protein modification process//translation GO:0003735//GO:0033743//GO:0016151 structural constituent of ribosome//peptide-methionine (R)-S-oxide reductase activity//nickel cation binding GO:0005840//GO:0005622 ribosome//intracellular KOG3475 60S ribosomal protein L37 Cluster-17785.0 BF_2 1.00 0.36 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17786.0 BF_2 9.00 0.56 956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17796.0 BF_2 3.00 1.57 364 321475354 EFX86317.1 415 1.8e-38 hypothetical protein DAPPUDRAFT_92230 [Daphnia pulex] 591362614 XM_007056153.1 59 2.41764e-20 PREDICTED: Chelonia mydas barrier to autointegration factor 1 (BANF1), mRNA -- -- -- -- Q6P026 351 1.9e-32 Barrier-to-autointegration factor OS=Danio rerio GN=banf1 PE=1 SV=1 PF02961 Barrier to autointegration factor -- -- GO:0003677 DNA binding -- -- KOG4233 DNA-bridging protein BAF Cluster-17805.0 BF_2 5.00 1.59 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17808.0 BF_2 3.00 1.28 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17811.0 BF_2 5.00 0.78 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17812.0 BF_2 3.00 0.35 644 675370211 KFM63113.1 591 1.2e-58 Beta-hexosaminidase subunit beta, partial [Stegodyphus mimosarum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49614 435 6.2e-42 Beta-hexosaminidase subunit beta OS=Felis catus GN=HEXB PE=2 SV=2 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-17819.0 BF_2 3.00 0.37 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-17827.0 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17831.0 BF_2 4.00 1.53 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17833.0 BF_2 4.00 1.21 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17844.0 BF_2 18.78 0.61 1578 642936936 XP_970102.2 1378 1.7e-149 PREDICTED: tachykinin-like peptides receptor 99D [Tribolium castaneum] -- -- -- -- -- K04224 TACR3 tachykinin receptor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04224 P30975 1014 1.1e-108 Tachykinin-like peptides receptor 99D OS=Drosophila melanogaster GN=TkR99D PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4219 G protein-coupled receptor Cluster-17845.0 BF_2 2.00 0.49 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17847.1 BF_2 15.27 1.14 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05196 PTN/MK heparin-binding protein family, N-terminal domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity -- -- -- -- Cluster-17847.2 BF_2 27.58 2.12 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05196 PTN/MK heparin-binding protein family, N-terminal domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-17847.3 BF_2 1.15 0.32 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17854.1 BF_2 17.97 0.37 2303 195500774 XP_002097518.1 457 1.5e-42 GE24449 [Drosophila yakuba]>gi|194183619|gb|EDW97230.1| GE24449 [Drosophila yakuba] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 452 2.4e-43 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083//PF02450 Partial alpha/beta-hydrolase lipase region//Lecithin:cholesterol acyltransferase GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity -- -- -- -- Cluster-17856.0 BF_2 2.00 0.64 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17858.0 BF_2 10.00 2.10 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17860.1 BF_2 4.00 0.38 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05118 Aspartyl/Asparaginyl beta-hydroxylase GO:0018193 peptidyl-amino acid modification -- -- -- -- -- -- Cluster-17863.0 BF_2 3.00 0.55 515 12005918 AAG44670.1 778 2.0e-80 CDA016 [Homo sapiens] 260763954 NM_015965.6 515 0 Homo sapiens NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 (NDUFA13), mRNA K11353 NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11353 Q9P0J0 770 7.1e-81 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Homo sapiens GN=NDUFA13 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3300 NADH:ubiquinone oxidoreductase, B16.6 subunit/cell death-regulatory protein Cluster-17867.0 BF_2 2.00 0.48 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17870.0 BF_2 14.00 0.54 1367 642938791 XP_008199888.1 907 6.0e-95 PREDICTED: uncharacterized protein LOC657763 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17871.0 BF_2 10.13 0.79 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17874.2 BF_2 13.00 0.32 2005 391330369 XP_003739635.1 1813 7.7e-200 PREDICTED: fatty acid synthase-like [Metaseiulus occidentalis] 847006484 XM_012948019.1 84 1.8211e-33 PREDICTED: Jaculus jaculus fatty acid synthase (Fasn), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1310 6.7e-143 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00975//PF00106 Thioesterase domain//short chain dehydrogenase GO:0009058//GO:0008152 biosynthetic process//metabolic process GO:0016491//GO:0016788 oxidoreductase activity//hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-17875.0 BF_2 4.00 0.33 799 270013391 EFA09839.1 174 3.5e-10 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17880.0 BF_2 1.00 0.41 388 195398885 XP_002058051.1 136 4.3e-06 GJ15703 [Drosophila virilis]>gi|194150475|gb|EDW66159.1| GJ15703 [Drosophila virilis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05051 Cytochrome C oxidase copper chaperone (COX17) GO:0006825 copper ion transport GO:0005507//GO:0016531 copper ion binding//copper chaperone activity GO:0005758 mitochondrial intermembrane space KOG3496 Cytochrome c oxidase assembly protein/Cu2+ chaperone COX17 Cluster-17881.0 BF_2 2.00 0.44 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17890.0 BF_2 6.00 1.13 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17891.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17892.0 BF_2 1.00 1.82 289 -- -- -- -- -- 768311754 CP010982.1 161 3.71806e-77 Verticillium dahliae VdLs.17 chromosome 3, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17901.0 BF_2 4.00 0.99 455 646722304 KDR23317.1 179 5.2e-11 hypothetical protein L798_05278 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17905.0 BF_2 2.00 0.40 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17912.0 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17913.0 BF_2 8.08 0.52 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17914.0 BF_2 4.00 0.69 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17914.1 BF_2 2.00 0.52 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17919.0 BF_2 2.00 0.35 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17927.0 BF_2 4.00 0.60 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17932.0 BF_2 2.92 1.02 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17946.0 BF_2 3.00 0.33 673 646711968 KDR16950.1 534 5.2e-52 Anion exchange protein 2, partial [Zootermopsis nevadensis] -- -- -- -- -- K13855 SLC4A2, AE2 solute carrier family 4 (anion exchanger), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13855 P13808 462 4.8e-45 Anion exchange protein 2 OS=Mus musculus GN=Slc4a2 PE=1 SV=1 PF00955 HCO3- transporter family GO:0006820 anion transport -- -- GO:0016021 integral component of membrane -- -- Cluster-17948.0 BF_2 6.00 0.79 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17949.0 BF_2 20.90 0.38 2560 478415060 AGI97279.1 283 2.5e-22 activating transcription factor 4 [Litopenaeus vannamei] 478415059 JX908828.1 38 8.69739e-08 Litopenaeus vannamei activating transcription factor 4 (ATF4) mRNA, complete cds K09044 ATF5 activating transcription factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09044 Q9GPH3 180 9.2e-12 Activating transcription factor of chaperone OS=Bombyx mori GN=ATFC PE=2 SV=1 PF07716//PF00170//PF03131 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4571 Activating transcription factor 4 Cluster-17955.0 BF_2 5.83 0.34 1008 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-1796.0 BF_2 2.00 0.48 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17962.0 BF_2 5.00 0.55 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17973.0 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17974.0 BF_2 2.00 0.32 552 759177751 XP_011378212.1 791 6.8e-82 PREDICTED: LOW QUALITY PROTEIN: casein kinase II subunit beta [Pteropus vampyrus] 805757426 XM_012290953.1 92 1.71064e-38 PREDICTED: Megachile rotundata casein kinase II subunit beta (LOC100880852), transcript variant X12, mRNA K03115 CSNK2B casein kinase II subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03115 P67868 784 1.8e-82 Casein kinase II subunit beta OS=Bos taurus GN=CSNK2B PE=1 SV=1 PF01214 Casein kinase II regulatory subunit GO:0045859 regulation of protein kinase activity GO:0019887 protein kinase regulator activity GO:0005956 protein kinase CK2 complex KOG3092 Casein kinase II, beta subunit Cluster-17975.0 BF_2 3.00 1.01 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17976.0 BF_2 16.00 0.51 1603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-17977.0 BF_2 14.00 0.42 1667 768431183 XP_011556856.1 1406 1.0e-152 PREDICTED: carbonic anhydrase-related protein 10 [Plutella xylostella] 642920813 XM_008194349.1 496 0 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC661205), mRNA -- -- -- -- Q5R4U0 676 1.8e-69 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-17984.0 BF_2 3.00 0.59 500 242000046 XP_002434666.1 531 8.7e-52 estradiol 17-beta-dehydrogenase, putative [Ixodes scapularis]>gi|215497996|gb|EEC07490.1| estradiol 17-beta-dehydrogenase, putative [Ixodes scapularis] -- -- -- -- -- K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 P51659 353 1.6e-32 Peroxisomal multifunctional enzyme type 2 OS=Homo sapiens GN=HSD17B4 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0000166//GO:0033989//GO:0032934//GO:0016491 nucleotide binding//3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity//sterol binding//oxidoreductase activity -- -- -- -- Cluster-17987.0 BF_2 9.00 1.03 653 795342189 XP_011929989.1 902 1.1e-94 PREDICTED: 60S ribosomal protein L17 isoform X1 [Cercocebus atys] 313569765 NM_000985.4 653 0 Homo sapiens ribosomal protein L17 (RPL17), transcript variant 1, mRNA K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 Q5XTY7 889 1.4e-94 60S ribosomal protein L17 OS=Felis catus GN=RPL17 PE=2 SV=3 PF00237 Ribosomal protein L22p/L17e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-17989.0 BF_2 1.00 1.87 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18000.0 BF_2 12.00 0.57 1168 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18004.0 BF_2 18.64 0.42 2124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18006.0 BF_2 12.00 1.77 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18011.0 BF_2 6.00 0.84 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08472//PF08463//PF05823//PF00995//PF01442 Sucrose-6-phosphate phosphohydrolase C-terminal//EcoEI R protein C-terminal//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Sec1 family//Apolipoprotein A1/A4/E domain GO:0006304//GO:0005986//GO:0006869//GO:0006904//GO:0016192//GO:0005982//GO:0005985//GO:0042157 DNA modification//sucrose biosynthetic process//lipid transport//vesicle docking involved in exocytosis//vesicle-mediated transport//starch metabolic process//sucrose metabolic process//lipoprotein metabolic process GO:0050307//GO:0008289//GO:0003824//GO:0003677 sucrose-phosphate phosphatase activity//lipid binding//catalytic activity//DNA binding GO:0005576 extracellular region -- -- Cluster-18017.0 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18033.1 BF_2 2.00 0.46 469 242019605 XP_002430250.1 405 3.3e-37 40S ribosomal protein S2, putative [Pediculus humanus corporis]>gi|212515357|gb|EEB17512.1| 40S ribosomal protein S2, putative [Pediculus humanus corporis] 115456088 NM_001058180.1 286 2.06275e-146 Oryza sativa Japonica Group Os03g0807800 (Os03g0807800) mRNA, complete cds K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 O74892 413 1.6e-39 40S ribosomal protein S2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps2 PE=1 SV=1 PF00333//PF02166 Ribosomal protein S5, N-terminal domain//Androgen receptor GO:0030521//GO:0006355//GO:0042254//GO:0007165//GO:0006412 androgen receptor signaling pathway//regulation of transcription, DNA-templated//ribosome biogenesis//signal transduction//translation GO:0003735//GO:0005496//GO:0003677//GO:0003723//GO:0004882 structural constituent of ribosome//steroid binding//DNA binding//RNA binding//androgen receptor activity GO:0005840//GO:0005634//GO:0015935 ribosome//nucleus//small ribosomal subunit KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-18034.0 BF_2 5.00 0.87 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18037.1 BF_2 1.00 0.36 401 241581367 XP_002403503.1 528 1.5e-51 fatty acid synthase, putative [Ixodes scapularis]>gi|215502217|gb|EEC11711.1| fatty acid synthase, putative [Ixodes scapularis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 446 2.0e-43 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- GO:0006633//GO:0055114//GO:0009058//GO:0042967 fatty acid biosynthetic process//oxidation-reduction process//biosynthetic process//acyl-carrier-protein biosynthetic process GO:0004316//GO:0004319//GO:0016295//GO:0004320//GO:0000166//GO:0008270//GO:0016296//GO:0004313//GO:0004314//GO:0004317//GO:0004315 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity//enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity//myristoyl-[acyl-carrier-protein] hydrolase activity//oleoyl-[acyl-carrier-protein] hydrolase activity//nucleotide binding//zinc ion binding//palmitoyl-[acyl-carrier-protein] hydrolase activity//[acyl-carrier-protein] S-acetyltransferase activity//[acyl-carrier-protein] S-malonyltransferase activity//3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-18042.0 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18049.0 BF_2 8.00 0.67 784 -- -- -- -- -- 13241679 AF321227.1 61 4.23346e-21 AF321227 Tribolium castaneum Ftz (ftz), Scr (scr), Dfd (dfd), Zen (zen), and Zen2 (zen2) genes, complete cds; and Pb (pb) gene, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18059.0 BF_2 4.00 0.44 670 762121059 XP_011443445.1 779 2.0e-80 PREDICTED: dipeptidyl peptidase 1-like [Crassostrea gigas] -- -- -- -- -- K01275 CTSC cathepsin C http://www.genome.jp/dbget-bin/www_bget?ko:K01275 P53634 735 1.1e-76 Dipeptidyl peptidase 1 OS=Homo sapiens GN=CTSC PE=1 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-18060.0 BF_2 2.00 2.02 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18063.0 BF_2 7.00 0.74 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18066.0 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18069.1 BF_2 4.00 0.32 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q13489 125 6.9e-06 Baculoviral IAP repeat-containing protein 3 OS=Homo sapiens GN=BIRC3 PE=1 SV=2 PF01667 Ribosomal protein S27 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-18071.0 BF_2 1.00 0.34 410 328699348 XP_003240910.1 200 1.7e-13 PREDICTED: uncharacterized protein LOC100571439 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18076.0 BF_2 1.00 0.98 320 686726728 XP_009241601.1 240 3.1e-18 PREDICTED: uncharacterized protein LOC100939869 [Pongo abelii] 35931950 AC146010.2 320 1.70744e-165 Pan troglodytes BAC clone RP43-16O20 from chromosome 7, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18081.0 BF_2 4.00 0.80 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18090.0 BF_2 1.00 0.39 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18093.0 BF_2 21.00 0.82 1362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18097.0 BF_2 4.00 3.20 332 676441940 XP_009049647.1 178 4.9e-11 hypothetical protein LOTGIDRAFT_238761 [Lottia gigantea]>gi|556111034|gb|ESO99685.1| hypothetical protein LOTGIDRAFT_238761 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-18100.0 BF_2 13.00 2.21 533 332245592 XP_003271942.1 714 5.6e-73 PREDICTED: 40S ribosomal protein S18 [Nomascus leucogenys] 92444018 BC012322.1 533 0 Homo sapiens mRNA similar to IGF-II mRNA-binding protein 2 (cDNA clone IMAGE:4652395) K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q3T0R1 697 2.1e-72 40S ribosomal protein S18 OS=Bos taurus GN=RPS18 PE=2 SV=3 PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3311 Ribosomal protein S18 Cluster-18113.0 BF_2 28.00 0.68 1999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01196//PF06624 Ribosomal protein L17//Ribosome associated membrane protein RAMP4 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622//GO:0005783 ribosome//intracellular//endoplasmic reticulum -- -- Cluster-18118.0 BF_2 1.00 0.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18119.0 BF_2 10.00 0.32 1576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01618//PF05435 MotA/TolQ/ExbB proton channel family//Phi-29 DNA terminal protein GP3 GO:0015031//GO:0006810//GO:0018142//GO:0006269//GO:0006260 protein transport//transport//protein-DNA covalent cross-linking//DNA replication, synthesis of RNA primer//DNA replication GO:0008565 protein transporter activity GO:0016020 membrane -- -- Cluster-18127.1 BF_2 34.00 11.14 414 642912932 XP_008201312.1 176 1.0e-10 PREDICTED: uncharacterized protein LOC103315149 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18131.0 BF_2 5.00 0.61 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18134.1 BF_2 4.00 1.45 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18145.0 BF_2 57.15 2.38 1293 642928332 XP_008195538.1 877 1.7e-91 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q641F6 391 1.6e-36 Lipase member H-B OS=Xenopus laevis GN=liph-b PE=2 SV=1 PF01764//PF07819//PF06821 Lipase (class 3)//PGAP1-like protein//Serine hydrolase GO:0006505//GO:0006629//GO:0006886 GPI anchor metabolic process//lipid metabolic process//intracellular protein transport GO:0016788//GO:0016787 hydrolase activity, acting on ester bonds//hydrolase activity -- -- -- -- Cluster-18149.0 BF_2 3.00 1.41 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18151.0 BF_2 3.00 0.35 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18153.0 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18158.0 BF_2 2.00 0.57 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18159.0 BF_2 18.29 1.50 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18163.0 BF_2 8.00 0.46 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18165.0 BF_2 7.00 0.48 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18175.1 BF_2 3.00 0.33 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01721//PF02790 Class II bacteriocin//Cytochrome C oxidase subunit II, transmembrane domain GO:0022900//GO:0042742 electron transport chain//defense response to bacterium -- -- GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-18176.0 BF_2 10.00 0.79 817 815819257 XP_012230799.1 749 7.4e-77 PREDICTED: RNA-binding protein squid isoform X1 [Linepithema humile] 815819258 XM_012375377.1 121 1.95695e-54 PREDICTED: Linepithema humile RNA-binding protein squid (LOC105677047), transcript variant X2, mRNA K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 717 1.6e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF08777//PF04355//PF00076//PF06177//PF16367 RNA binding motif//SmpA / OmlA family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//QueT transporter//RNA recognition motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0005886//GO:0019867 plasma membrane//outer membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-18190.0 BF_2 3.00 0.33 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18201.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18203.0 BF_2 21.00 0.73 1496 146217394 ABQ10739.1 1397 9.9e-152 cathepsin L [Penaeus monodon] 11052 X63568.1 59 1.06645e-19 H.americanus mRNA for cysteine proteinase preproenzyme K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1188 7.0e-129 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-18205.0 BF_2 11.00 3.12 434 4557695 NP_000213.1 500 3.0e-48 mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens]>gi|125472|sp|P10721.1|KIT_HUMAN RecName: Full=Mast/stem cell growth factor receptor Kit; Short=SCFR; AltName: Full=Piebald trait protein; Short=PBT; AltName: Full=Proto-oncogene c-Kit; AltName: Full=Tyrosine-protein kinase Kit; AltName: Full=p145 c-kit; AltName: Full=v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; AltName: CD_antigen=CD117; Flags: Precursor>gi|34085|emb|CAA29548.1| unnamed protein product [Homo sapiens]>gi|825686|emb|CAA49159.1| mast/stem cell growth factor receptor [Homo sapiens]>gi|1817733|gb|AAC50968.1| KIT protein [Homo sapiens]>gi|119625865|gb|EAX05460.1| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, isoform CRA_a [Homo sapiens]>gi|119625866|gb|EAX05461.1| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, isoform CRA_a [Homo sapiens] 170014706 NG_007456.1 434 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P10721 500 1.2e-49 Mast/stem cell growth factor receptor Kit OS=Homo sapiens GN=KIT PE=1 SV=1 -- -- GO:0010628//GO:0000187//GO:0006687//GO:0008284//GO:0002551//GO:0046777//GO:0038162//GO:0097326//GO:0038093//GO:0007165//GO:0035162//GO:0030217//GO:0019827//GO:0035234//GO:0050910//GO:0030032//GO:0030218//GO:0097324//GO:0032762//GO:0001541//GO:0009314//GO:0010863//GO:0014068//GO:0030318//GO:0042523//GO:0002371//GO:0043552//GO:0070662//GO:0008360//GO:0042511//GO:0023014//GO:0002320//GO:0048070//GO:0060374//GO:0038109//GO:0007286//GO:0007169//GO:0035855//GO:0042517//GO:0048565//GO:0002318//GO:0006954//GO:0002327//GO:0051091//GO:0008584//GO:0043303//GO:0097067//GO:0043069//GO:0031532 positive regulation of gene expression//activation of MAPK activity//glycosphingolipid metabolic process//positive regulation of cell proliferation//mast cell chemotaxis//protein autophosphorylation//erythropoietin-mediated signaling pathway//melanocyte adhesion//Fc receptor signaling pathway//signal transduction//embryonic hemopoiesis//T cell differentiation//stem cell population maintenance//ectopic germ cell programmed cell death//detection of mechanical stimulus involved in sensory perception of sound//lamellipodium assembly//erythrocyte differentiation//melanocyte migration//mast cell cytokine production//ovarian follicle development//response to radiation//positive regulation of phospholipase C activity//positive regulation of phosphatidylinositol 3-kinase signaling//melanocyte differentiation//positive regulation of tyrosine phosphorylation of Stat5 protein//dendritic cell cytokine production//positive regulation of phosphatidylinositol 3-kinase activity//mast cell proliferation//regulation of cell shape//positive regulation of tyrosine phosphorylation of Stat1 protein//signal transduction by protein phosphorylation//lymphoid progenitor cell differentiation//regulation of developmental pigmentation//mast cell differentiation//Kit signaling pathway//spermatid development//transmembrane receptor protein tyrosine kinase signaling pathway//megakaryocyte development//positive regulation of tyrosine phosphorylation of Stat3 protein//digestive tract development//myeloid progenitor cell differentiation//inflammatory response//immature B cell differentiation//positive regulation of sequence-specific DNA binding transcription factor activity//male gonad development//mast cell degranulation//cellular response to thyroid hormone stimulus//negative regulation of programmed cell death//actin cytoskeleton reorganization GO:0002020//GO:0019955//GO:0042803//GO:0005020//GO:0005524//GO:0046872//GO:0004716 protease binding//cytokine binding//protein homodimerization activity//stem cell factor receptor activity//ATP binding//metal ion binding//receptor signaling protein tyrosine kinase activity GO:0005737//GO:0016021//GO:0005634//GO:0005615//GO:0009897 cytoplasm//integral component of membrane//nucleus//extracellular space//external side of plasma membrane -- -- Cluster-18206.0 BF_2 1.00 0.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18207.0 BF_2 4.00 0.45 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18211.0 BF_2 7.00 0.62 756 675377463 KFM70365.1 238 1.2e-17 Chondroitin proteoglycan 2, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- A8XWX5 161 4.3e-10 Chondroitin proteoglycan 2 OS=Caenorhabditis briggsae GN=cpg-2 PE=3 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-18214.0 BF_2 3.00 1.01 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18217.0 BF_2 4.00 0.44 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18225.0 BF_2 2.00 0.64 417 -- -- -- -- -- 114386733 DQ859905.1 67 1.00166e-24 Hyas araneus arasin-2 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18226.0 BF_2 2.00 0.35 527 861647134 KMQ95803.1 731 5.9e-75 26s protease regulatory subunit s10b [Lasius niger] 260803779 XM_002596721.1 177 9.12928e-86 Branchiostoma floridae hypothetical protein, mRNA K03064 PSMC6, RPT4 26S proteasome regulatory subunit T4 http://www.genome.jp/dbget-bin/www_bget?ko:K03064 P62335 714 2.3e-74 26S protease regulatory subunit 10B OS=Spermophilus tridecemlineatus GN=PSMC6 PE=2 SV=1 PF09177//PF04111//PF04977//PF07926//PF10018//PF06810 Syntaxin 6, N-terminal//Autophagy protein Apg6//Septum formation initiator//TPR/MLP1/MLP2-like protein//Vitamin-D-receptor interacting Mediator subunit 4//Phage minor structural protein GP20 GO:0007049//GO:0006606//GO:0006357//GO:0006914//GO:0048193 cell cycle//protein import into nucleus//regulation of transcription from RNA polymerase II promoter//autophagy//Golgi vesicle transport GO:0005198//GO:0001104 structural molecule activity//RNA polymerase II transcription cofactor activity GO:0016020//GO:0016592 membrane//mediator complex KOG0651 26S proteasome regulatory complex, ATPase RPT4 Cluster-18230.0 BF_2 1.00 0.51 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08272 Topoisomerase I zinc-ribbon-like GO:0006265 DNA topological change GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005694 chromosome -- -- Cluster-18233.0 BF_2 12.00 0.62 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18233.1 BF_2 5.00 1.15 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18237.0 BF_2 10.00 0.88 760 478256752 ENN76933.1 260 3.5e-20 hypothetical protein YQE_06580, partial [Dendroctonus ponderosae]>gi|546679209|gb|ERL89703.1| hypothetical protein D910_07066 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18254.0 BF_2 36.00 0.83 2095 91089117 XP_972346.1 1913 2.0e-211 PREDICTED: pickpocket protein 28-like [Tribolium castaneum] -- -- -- -- -- K03440 ASICN amiloride-sensitive sodium channel, other http://www.genome.jp/dbget-bin/www_bget?ko:K03440 Q86LG1 502 3.4e-49 Pickpocket protein 28 OS=Drosophila melanogaster GN=ppk28 PE=1 SV=2 PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-18256.0 BF_2 5.00 0.77 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01313 Bacterial export proteins, family 3 GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-18259.0 BF_2 8.00 1.83 470 584482884 AHJ09939.1 559 4.6e-55 glycoside hydrolase family 28 [Apriona japonica] 584482885 KF724642.1 130 1.08483e-59 Apriona japonica glycoside hydrolase family 28 (gh28-2) mRNA, complete cds -- -- -- -- A1CIV8 344 1.6e-31 Probable endopolygalacturonase I OS=Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1) GN=pgaI PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005975//GO:0005982//GO:0005985 carbohydrate metabolic process//starch metabolic process//sucrose metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-18260.0 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18266.0 BF_2 4.00 0.74 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18268.0 BF_2 3.00 0.73 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18271.0 BF_2 2.00 0.35 527 688551929 XP_009299235.1 454 7.7e-43 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14590 409 5.3e-39 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF00096//PF01155//PF13912//PF04810//PF02892//PF00412//PF16622//PF13465//PF07975 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//LIM domain//zinc-finger C2H2-type//Zinc-finger double domain//TFIIH C1-like domain GO:0006888//GO:0006886//GO:0006281//GO:0006464 ER to Golgi vesicle-mediated transport//intracellular protein transport//DNA repair//cellular protein modification process GO:0016151//GO:0003677//GO:0046872//GO:0008270 nickel cation binding//DNA binding//metal ion binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-18274.0 BF_2 7.00 1.06 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18275.0 BF_2 3.00 1.94 347 762081924 XP_011422687.1 186 6.1e-12 PREDICTED: nidogen-2-like [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-18277.0 BF_2 16.00 0.54 1536 748995298 AJE75671.1 1292 1.5e-139 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1130 3.8e-122 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-18281.0 BF_2 3.00 0.32 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18284.0 BF_2 3.00 0.39 609 478260386 ENN80129.1 138 3.9e-06 hypothetical protein YQE_03437, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-18286.0 BF_2 9.00 0.68 844 562845331 XP_006151600.1 1024 1.0e-108 PREDICTED: 60S acidic ribosomal protein P0 isoform X1 [Tupaia chinensis] 47940122 BC071911.1 844 0 Homo sapiens cDNA clone IMAGE:6569344, **** WARNING: chimeric clone **** K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 P05388 1030 8.3e-111 60S acidic ribosomal protein P0 OS=Homo sapiens GN=RPLP0 PE=1 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0815 60S acidic ribosomal protein P0 Cluster-18292.0 BF_2 10.00 0.94 731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18298.0 BF_2 6.00 0.89 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18300.0 BF_2 2.00 7.48 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-18307.0 BF_2 5.00 0.53 683 871221718 XP_012935966.1 359 1.0e-31 PREDICTED: LOW QUALITY PROTEIN: prostamide/prostaglandin F synthase-like [Aplysia californica] -- -- -- -- -- K15717 K15717 prostamide/prostaglandin F2alpha synthase http://www.genome.jp/dbget-bin/www_bget?ko:K15717 C1C416 315 5.4e-28 Prostamide/prostaglandin F synthase OS=Lithobates catesbeiana GN=fam213b PE=2 SV=1 PF08534//PF02888//PF00578 Redoxin//Calmodulin binding domain//AhpC/TSA family GO:0055114//GO:0006813 oxidation-reduction process//potassium ion transport GO:0015269//GO:0016491//GO:0016209//GO:0005516 calcium-activated potassium channel activity//oxidoreductase activity//antioxidant activity//calmodulin binding GO:0016021 integral component of membrane -- -- Cluster-18318.0 BF_2 2.00 0.40 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18324.0 BF_2 5.00 0.54 673 225714206 ACO12949.1 218 2.3e-15 Cuticle protein 7 [Lepeophtheirus salmonis] -- -- -- -- -- -- -- -- -- Q17015 166 1.0e-10 Cuticle protein OS=Anopheles gambiae GN=Ccp84Ab PE=2 SV=3 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-18325.0 BF_2 2.00 0.77 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18326.0 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04882 Peroxin-3 GO:0007031 peroxisome organization -- -- GO:0005779 integral component of peroxisomal membrane -- -- Cluster-18329.0 BF_2 5.00 0.62 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18345.0 BF_2 13.86 0.86 965 332376733 AEE63506.1 531 1.7e-51 unknown [Dendroctonus ponderosae]>gi|478250681|gb|ENN71173.1| hypothetical protein YQE_12103, partial [Dendroctonus ponderosae]>gi|546678633|gb|ERL89215.1| hypothetical protein D910_06589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18348.0 BF_2 3.00 0.85 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18350.0 BF_2 7.00 0.44 948 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18352.0 BF_2 2.00 0.35 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18362.0 BF_2 4.00 0.70 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18370.0 BF_2 8.00 0.59 854 260823104 XP_002604023.1 240 8.2e-18 hypothetical protein BRAFLDRAFT_71688 [Branchiostoma floridae]>gi|229289348|gb|EEN60034.1| hypothetical protein BRAFLDRAFT_71688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- O14709 196 4.3e-14 Zinc finger protein 197 OS=Homo sapiens GN=ZNF197 PE=2 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-18375.0 BF_2 10.47 0.39 1424 642927632 XP_008195342.1 514 2.3e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 1.1e-27 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0004721//GO:0008138 protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-18375.1 BF_2 9.98 0.35 1476 642927632 XP_008195342.1 514 2.4e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 1.2e-27 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-18376.0 BF_2 2.00 1.27 348 391325864 XP_003737447.1 299 4.8e-25 PREDICTED: 40S ribosomal protein S21-like isoform 1 [Metaseiulus occidentalis]>gi|391325866|ref|XP_003737448.1| PREDICTED: 40S ribosomal protein S21-like isoform 2 [Metaseiulus occidentalis]>gi|391325868|ref|XP_003737449.1| PREDICTED: 40S ribosomal protein S21-like isoform 3 [Metaseiulus occidentalis] -- -- -- -- -- K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4PM64 295 5.7e-26 40S ribosomal protein S21 OS=Ixodes scapularis GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-18377.0 BF_2 1.00 4.80 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18382.0 BF_2 1.00 1.40 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18382.1 BF_2 4.00 5.49 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18385.0 BF_2 2.00 0.33 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18387.0 BF_2 4.00 0.41 697 391330369 XP_003739635.1 350 1.2e-30 PREDICTED: fatty acid synthase-like [Metaseiulus occidentalis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 305 8.0e-27 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-18392.1 BF_2 10.00 0.34 1532 546685567 ERL95054.1 542 1.4e-52 hypothetical protein D910_12324 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D3D0 201 2.0e-14 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 PF00861 Ribosomal L18p/L5e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-18406.1 BF_2 3.00 0.34 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622 zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-18430.0 BF_2 14.00 0.38 1824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18435.0 BF_2 45.00 0.90 2376 91084203 XP_967906.1 1181 1.8e-126 PREDICTED: transmembrane protein 53 [Tribolium castaneum]>gi|270008767|gb|EFA05215.1| hypothetical protein TcasGA2_TC015355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5PPS7 349 2.2e-31 Transmembrane protein 53-A OS=Xenopus laevis GN=tmem53-a PE=2 SV=1 PF02230//PF00326 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2521 Uncharacterized conserved protein Cluster-18438.0 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18448.0 BF_2 4.00 0.32 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18457.0 BF_2 7.00 0.40 1012 391328505 XP_003738729.1 946 1.3e-99 PREDICTED: cathepsin L-like [Metaseiulus occidentalis] 768950344 XM_003975074.2 61 5.52043e-21 PREDICTED: Takifugu rubripes cathepsin L (ctsl), transcript variant X2, mRNA K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 815 8.5e-86 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF05479//PF00112//PF03051 Photosystem I reaction centre subunit N (PSAN or PSI-N)//Papain family cysteine protease//Peptidase C1-like family GO:0015979//GO:0006508 photosynthesis//proteolysis GO:0008234//GO:0005516//GO:0004197 cysteine-type peptidase activity//calmodulin binding//cysteine-type endopeptidase activity GO:0042651//GO:0009522 thylakoid membrane//photosystem I KOG1543 Cysteine proteinase Cathepsin L Cluster-18459.0 BF_2 9.00 0.36 1331 270015961 EFA12409.1 537 4.7e-52 hypothetical protein TcasGA2_TC016411 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY51 291 6.4e-25 Tigger transposable element-derived protein 4 OS=Homo sapiens GN=TIGD4 PE=2 SV=2 PF01498//PF03184 Transposase//DDE superfamily endonuclease GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-18459.1 BF_2 6.00 0.37 959 641660525 XP_008181524.1 508 7.7e-49 PREDICTED: tigger transposable element-derived protein 6-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q8BUZ3 414 2.5e-39 Tigger transposable element-derived protein 4 OS=Mus musculus GN=Tigd4 PE=2 SV=1 PF01130//PF04218 CD36 family//CENP-B N-terminal DNA-binding domain GO:0007155 cell adhesion GO:0003677 DNA binding GO:0016020 membrane KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-18463.0 BF_2 1.00 0.31 420 820972315 XP_012370968.1 359 6.4e-32 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 isoform X2 [Octodon degus] -- -- -- -- -- K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q96K76 355 7.6e-33 Ubiquitin carboxyl-terminal hydrolase 47 OS=Homo sapiens GN=USP47 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-18465.0 BF_2 3.00 1.26 385 642935122 XP_008197897.1 419 6.5e-39 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18466.0 BF_2 8.00 1.62 494 241029422 XP_002406430.1 476 2.0e-45 40S ribosomal protein S15, putative [Ixodes scapularis]>gi|51011510|gb|AAT92164.1| ribosomal protein S15 [Ixodes pacificus]>gi|67084009|gb|AAY66939.1| ribosomal protein S15 [Ixodes scapularis]>gi|215491960|gb|EEC01601.1| 40S ribosomal protein S15, putative [Ixodes scapularis] 457867062 HF570325.1 75 4.29452e-29 Sycon ciliatum mRNA for 40S ribosomal protein S15 (rps15 gene) K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 P62845 441 9.6e-43 40S ribosomal protein S15 OS=Rattus norvegicus GN=Rps15 PE=1 SV=2 PF00203 Ribosomal protein S19 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0030529 ribosome//intracellular ribonucleoprotein complex KOG0898 40S ribosomal protein S15 Cluster-18468.0 BF_2 2.00 0.48 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18469.0 BF_2 2.00 0.56 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18470.1 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18474.0 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18475.0 BF_2 2.00 0.96 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18477.0 BF_2 13.00 1.85 581 -- -- -- -- -- 33111956 AJ577263.1 131 3.7743e-60 Quercus robur partial mRNA for metallothionein-like protein (ORF1) -- -- -- -- P43390 212 4.0e-16 Metallothionein-like protein type 2 OS=Actinidia deliciosa GN=pKIWI504 PE=2 SV=1 PF02068//PF00131//PF01439 Plant PEC family metallothionein//Metallothionein//Metallothionein -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-18481.0 BF_2 4.00 0.77 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18492.0 BF_2 3.00 0.49 543 241998156 XP_002433721.1 398 2.5e-36 heat shock protein [Ixodes scapularis]>gi|51011554|gb|AAT92186.1| heat shock protein 10 [Ixodes pacificus]>gi|215495480|gb|EEC05121.1| heat shock protein [Ixodes scapularis] -- -- -- -- -- K04078 groES, HSPE1 chaperonin GroES http://www.genome.jp/dbget-bin/www_bget?ko:K04078 Q9W6X3 317 2.5e-28 10 kDa heat shock protein, mitochondrial OS=Oryzias latipes GN=hspe1 PE=3 SV=1 PF00166 Chaperonin 10 Kd subunit GO:0006457//GO:0006950 protein folding//response to stress GO:0005524 ATP binding GO:0005737 cytoplasm KOG1641 Mitochondrial chaperonin Cluster-18494.0 BF_2 1.00 0.32 419 443708151 ELU03406.1 445 6.8e-42 hypothetical protein CAPTEDRAFT_168454 [Capitella teleta] -- -- -- -- -- K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 Q9C040 393 3.0e-37 Tripartite motif-containing protein 2 OS=Homo sapiens GN=TRIM2 PE=1 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG2177 Predicted E3 ubiquitin ligase Cluster-18496.0 BF_2 1.00 0.33 415 726968576 AIY53011.1 525 3.6e-51 NDUFA13 [Litopenaeus vannamei] -- -- -- -- -- K11353 NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11353 Q95KV7 194 3.5e-14 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 OS=Bos taurus GN=NDUFA13 PE=1 SV=3 PF04879 Molybdopterin oxidoreductase Fe4S4 domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3300 NADH:ubiquinone oxidoreductase, B16.6 subunit/cell death-regulatory protein Cluster-18507.0 BF_2 3.00 0.59 498 -- -- -- -- -- 768311752 CP010980.1 204 8.4326e-101 Verticillium dahliae VdLs.17 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18510.0 BF_2 8.00 0.53 919 602626089 XP_007420007.1 202 2.3e-13 PREDICTED: DNA damage-regulated autophagy modulator protein 1 isoform X1 [Python bivittatus] -- -- -- -- -- -- -- -- -- Q8N682 168 8.1e-11 DNA damage-regulated autophagy modulator protein 1 OS=Homo sapiens GN=DRAM1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-18516.0 BF_2 1.00 6.50 245 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18517.0 BF_2 8.00 1.23 559 30025643 AAP04352.1 560 4.2e-55 40S ribosomal protein S12 [Dermacentor variabilis] 192335737 EU829350.1 43 3.00565e-11 Linum usitatissimum clone LU0013H04 mRNA sequence K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P25398 496 4.6e-49 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3406 40S ribosomal protein S12 Cluster-18518.0 BF_2 13.00 0.58 1220 524998299 XP_005046911.1 224 8.4e-16 PREDICTED: mucin-2 [Ficedula albicollis] -- -- -- -- -- -- -- -- -- Q01589 212 8.5e-16 Cell wall protein SED1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SED1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-18531.0 BF_2 6.00 0.43 873 391340988 XP_003744815.1 289 1.7e-23 PREDICTED: uncharacterized protein LOC100899984 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18534.0 BF_2 37.00 3.07 792 156408429 XP_001641859.1 950 3.6e-100 predicted protein [Nematostella vectensis]>gi|156228999|gb|EDO49796.1| predicted protein [Nematostella vectensis] 637338280 XM_003225417.2 243 2.87118e-122 PREDICTED: Anolis carolinensis ribosomal protein S3 (rps3), mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 Q3T169 940 2.1e-100 40S ribosomal protein S3 OS=Bos taurus GN=RPS3 PE=2 SV=1 PF07650//PF13096 KH domain//CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P GO:0042254//GO:0034080//GO:0006412 ribosome biogenesis//CENP-A containing nucleosome assembly//translation GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840//GO:0000775//GO:0015935 ribosome//chromosome, centromeric region//small ribosomal subunit KOG3181 40S ribosomal protein S3 Cluster-18538.0 BF_2 1.00 1.78 290 -- -- -- -- -- 45860994 AC135598.4 281 7.31775e-144 Oryza sativa chromosome 3 BAC OSJNBb0021K20 genomic sequence, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18539.0 BF_2 9.33 0.31 1540 766918539 XP_011498898.1 703 3.0e-71 PREDICTED: heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog [Ceratosolen solmsi marchali] -- -- -- -- -- K13158 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 http://www.genome.jp/dbget-bin/www_bget?ko:K13158 P21522 682 3.4e-70 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF08777//PF03972 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif//MmgE/PrpD family -- -- GO:0003676//GO:0003723//GO:0016829 nucleic acid binding//RNA binding//lyase activity -- -- -- -- Cluster-18541.0 BF_2 2.00 0.33 542 91089543 XP_971483.1 304 2.0e-25 PREDICTED: uncharacterized protein LOC660130 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903//PF04608 PMP-22/EMP/MP20/Claudin tight junction//Phosphatidylglycerophosphatase A GO:0046486//GO:0006629 glycerolipid metabolic process//lipid metabolic process GO:0008962 phosphatidylglycerophosphatase activity GO:0016021 integral component of membrane -- -- Cluster-18542.1 BF_2 12.00 0.49 1305 270011348 EFA07796.1 1000 9.4e-106 hypothetical protein TcasGA2_TC005357 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGK2 527 2.7e-52 Tetratricopeptide repeat protein 39C OS=Rattus norvegicus GN=Ttc39c PE=2 SV=1 PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-18546.0 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00278//PF06645 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Microsomal signal peptidase 12 kDa subunit (SPC12) GO:0006465 signal peptide processing GO:0008233//GO:0003824 peptidase activity//catalytic activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-18560.0 BF_2 5.00 0.43 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18560.1 BF_2 3.00 0.58 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18570.0 BF_2 3.00 1.27 384 625198250 XP_007641182.1 235 1.4e-17 PREDICTED: protein transport protein Sec61 subunit gamma isoform X1 [Cricetulus griseus]>gi|625287921|ref|XP_007635681.1| PREDICTED: protein transport protein Sec61 subunit gamma isoform X1 [Cricetulus griseus] 195132636 XM_002010713.1 101 1.15133e-43 Drosophila mojavensis GI21533 (Dmoj\GI21533), mRNA K07342 SEC61G, SSS1, secE protein transport protein SEC61 subunit gamma and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K07342 Q66KU2 229 2.8e-18 Protein transport protein Sec61 subunit gamma OS=Xenopus laevis GN=sec61g PE=3 SV=1 PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006605//GO:0006886 protein targeting//intracellular protein transport -- -- GO:0016020 membrane KOG3498 Preprotein translocase, gamma subunit Cluster-18577.0 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04987 Phosphatidylinositolglycan class N (PIG-N) GO:0006506 GPI anchor biosynthetic process GO:0016740 transferase activity GO:0005789 endoplasmic reticulum membrane -- -- Cluster-18578.0 BF_2 12.00 0.65 1065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18582.0 BF_2 2.00 0.99 369 83628250 ABC26005.1 261 1.3e-20 arthrodial cuticle protein AMP16.3 [Callinectes sapidus] -- -- -- -- -- -- -- -- -- P81576 254 3.5e-21 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-18584.0 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18587.0 BF_2 5.00 1.05 487 318086974 ADV40079.1 465 3.8e-44 60S ribosomal protein L27 [Latrodectus hesperus] -- -- -- -- -- K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 Q7ZV82 419 3.4e-40 60S ribosomal protein L27 OS=Danio rerio GN=rpl27 PE=2 SV=3 PF01777 Ribosomal L27e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3418 60S ribosomal protein L27 Cluster-18589.0 BF_2 2.00 4.21 283 66813248 XP_640803.1 344 2.4e-30 hypothetical protein DDB_G0281077 [Dictyostelium discoideum AX4]>gi|60468835|gb|EAL66835.1| hypothetical protein DDB_G0281077 [Dictyostelium discoideum AX4] -- -- -- -- -- K01368 CTSS cathepsin S http://www.genome.jp/dbget-bin/www_bget?ko:K01368 O70370 220 2.3e-17 Cathepsin S OS=Mus musculus GN=Ctss PE=1 SV=2 PF00112 Papain family cysteine protease GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-18598.2 BF_2 8.35 0.39 1175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18598.3 BF_2 13.00 0.65 1127 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18618.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18619.0 BF_2 8.00 2.29 433 241828736 XP_002416676.1 596 2.2e-59 ribosomal protein S15Aa, putative [Ixodes scapularis]>gi|215511140|gb|EEC20593.1| ribosomal protein S15Aa, putative [Ixodes scapularis] -- -- -- -- -- K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 P48149 580 6.4e-59 40S ribosomal protein S15Aa OS=Drosophila melanogaster GN=RpS15Aa PE=1 SV=2 PF00410 Ribosomal protein S8 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-18620.0 BF_2 1.00 0.33 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18620.1 BF_2 3.00 0.70 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18625.0 BF_2 4.00 1.20 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18626.0 BF_2 5.05 0.73 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18627.0 BF_2 6.00 0.64 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13939 Toxin TisB, type I toxin-antitoxin system GO:0022611//GO:0006820//GO:0009432 dormancy process//anion transport//SOS response GO:0005253 anion channel activity GO:0005887 integral component of plasma membrane -- -- Cluster-18631.0 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18645.0 BF_2 4.00 0.68 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18651.1 BF_2 6.00 0.35 997 642919667 XP_008192015.1 580 3.6e-57 PREDICTED: otopetrin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTS6 136 4.5e-07 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-18652.4 BF_2 9.00 0.53 1004 225709858 ACO10775.1 533 1.0e-51 DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Caligus rogercresseyi] 727011722 XM_010397285.1 95 6.8851e-40 PREDICTED: Corvus cornix cornix polymerase (RNA) II (DNA directed) polypeptide H (POLR2H), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 502 1.7e-49 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-18653.0 BF_2 3.00 0.41 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18655.0 BF_2 16.00 0.34 2249 270007490 EFA03938.1 669 3.9e-67 hypothetical protein TcasGA2_TC014079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18656.0 BF_2 12.00 0.34 1765 744514379 AJC97112.1 1002 7.4e-106 Rab1A [Macrobrachium rosenbergii] 262401000 FJ774681.1 644 0 Scylla paramamosain Ras-related protein Rab-1A mRNA, partial cds K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q05974 924 3.4e-98 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF03193//PF00005//PF10662//PF00071//PF04670//PF01926//PF07728//PF08477//PF02421//PF00025//PF00004 Protein of unknown function, DUF258//ABC transporter//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA) GO:0006576//GO:0007264//GO:0015684 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0003924//GO:0015093//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding//ATPase activity GO:0016021 integral component of membrane KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-18657.0 BF_2 3.00 0.67 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18672.0 BF_2 3.00 0.57 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18675.1 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18676.0 BF_2 1.00 1.29 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-18677.0 BF_2 28.00 1.05 1401 556765390 XP_005977958.1 206 1.2e-13 PREDICTED: pectinesterase QRT1-like [Pantholops hodgsonii] 802709094 XM_012229145.1 390 0 PREDICTED: Jatropha curcas probable pectinesterase/pectinesterase inhibitor 34 (LOC105643903), mRNA -- -- -- -- Q9M3B0 1619 6.9e-179 Probable pectinesterase/pectinesterase inhibitor 34 OS=Arabidopsis thaliana GN=PME34 PE=2 SV=1 PF01095 Pectinesterase GO:0005985//GO:0005982//GO:0042545 sucrose metabolic process//starch metabolic process//cell wall modification GO:0030599 pectinesterase activity GO:0005618 cell wall -- -- Cluster-197.1 BF_2 24.98 3.37 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-2321.2 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2334.0 BF_2 0.70 1.87 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2486.2 BF_2 3.00 0.40 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2516.1 BF_2 6.00 0.61 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2611.1 BF_2 2.00 1.16 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2718.1 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-2911.1 BF_2 2.00 0.38 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-294.1 BF_2 3.00 0.41 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3279.1 BF_2 8.00 0.76 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3326.1 BF_2 1.00 0.42 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-378.1 BF_2 2.00 2.92 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-3938.0 BF_2 2.00 0.39 502 262401277 ACY66541.1 246 9.7e-19 hypothetical protein [Scylla paramamosain] 262401276 FJ774820.1 357 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4142.1 BF_2 5.82 0.38 935 119369854 ABL67943.1 356 3.2e-31 nicotinic acetylcholine receptor subunit alpha 6 transcript variant 1, partial [Tribolium castaneum] 221222676 EU930066.1 171 3.61157e-82 Tribolium castaneum nicotinic acetylcholine receptor subunit a6 isoform III (nAChRA6) mRNA, complete cds, alternatively spliced K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 Q866A2 236 1.1e-18 Neuronal acetylcholine receptor subunit alpha-7 OS=Macaca mulatta GN=CHRNA7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3646 Acetylcholine receptor Cluster-4155.1 BF_2 2.00 2.34 310 471417752 XP_004390384.1 511 1.1e-49 PREDICTED: keratin, type I cytoskeletal 14 [Trichechus manatus latirostris] 261858813 AB527765.1 306 9.98851e-158 Synthetic construct DNA, clone: pF1KB5807, Homo sapiens KRT14 gene for keratin 14, without stop codon, in Flexi system K07604 KRT1 type I keratin, acidic http://www.genome.jp/dbget-bin/www_bget?ko:K07604 P02533 508 1.0e-50 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 PF04977//PF03836//PF07926//PF00038//PF10741//PF10186 Septum formation initiator//RasGAP C-terminus//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Type II secretion system (T2SS), protein M subtype b//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0007049//GO:0007264//GO:0010508//GO:0006858//GO:0006606 cell cycle//small GTPase mediated signal transduction//positive regulation of autophagy//extracellular transport//protein import into nucleus GO:0005198//GO:0005096 structural molecule activity//GTPase activator activity GO:0005882 intermediate filament -- -- Cluster-4155.2 BF_2 13.93 0.45 1592 635092416 XP_008010894.1 1599 4.0e-175 PREDICTED: keratin, type I cytoskeletal 14 [Chlorocebus sabaeus] 197313720 NM_000526.4 1385 0 Homo sapiens keratin 14, type I (KRT14), mRNA K07604 KRT1 type I keratin, acidic http://www.genome.jp/dbget-bin/www_bget?ko:K07604 P02533 1593 8.1e-176 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 PF08702//PF00038//PF07926//PF03836//PF10186//PF00445//PF04977//PF05791//PF07352 Fibrinogen alpha/beta chain family//Intermediate filament protein//TPR/MLP1/MLP2-like protein//RasGAP C-terminus//Vacuolar sorting 38 and autophagy-related subunit 14//Ribonuclease T2 family//Septum formation initiator//Bacillus haemolytic enterotoxin (HBL)//Bacteriophage Mu Gam like protein GO:0030168//GO:0007264//GO:0042262//GO:0006606//GO:0010508//GO:0007049//GO:0009405//GO:0007165//GO:0051258 platelet activation//small GTPase mediated signal transduction//DNA protection//protein import into nucleus//positive regulation of autophagy//cell cycle//pathogenesis//signal transduction//protein polymerization GO:0030674//GO:0003690//GO:0003723//GO:0005102//GO:0005096//GO:0005198//GO:0033897 protein binding, bridging//double-stranded DNA binding//RNA binding//receptor binding//GTPase activator activity//structural molecule activity//ribonuclease T2 activity GO:0016020//GO:0005577//GO:0005882 membrane//fibrinogen complex//intermediate filament -- -- Cluster-4155.3 BF_2 10.07 0.35 1477 635092416 XP_008010894.1 1589 5.3e-174 PREDICTED: keratin, type I cytoskeletal 14 [Chlorocebus sabaeus] 27769300 BC042437.1 1004 0 Homo sapiens keratin 14, mRNA (cDNA clone MGC:24954 IMAGE:4776763), complete cds K07604 KRT1 type I keratin, acidic http://www.genome.jp/dbget-bin/www_bget?ko:K07604 P02533 1583 1.1e-174 Keratin, type I cytoskeletal 14 OS=Homo sapiens GN=KRT14 PE=1 SV=4 PF06156//PF04977//PF05791//PF07352//PF00445//PF10186//PF07926//PF00038//PF08702 Protein of unknown function (DUF972)//Septum formation initiator//Bacillus haemolytic enterotoxin (HBL)//Bacteriophage Mu Gam like protein//Ribonuclease T2 family//Vacuolar sorting 38 and autophagy-related subunit 14//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Fibrinogen alpha/beta chain family GO:0007165//GO:0009405//GO:0051258//GO:0006260//GO:0006606//GO:0007049//GO:0010508//GO:0042262//GO:0030168 signal transduction//pathogenesis//protein polymerization//DNA replication//protein import into nucleus//cell cycle//positive regulation of autophagy//DNA protection//platelet activation GO:0005198//GO:0033897//GO:0005102//GO:0003723//GO:0030674//GO:0003690 structural molecule activity//ribonuclease T2 activity//receptor binding//RNA binding//protein binding, bridging//double-stranded DNA binding GO:0005882//GO:0005577//GO:0016020 intermediate filament//fibrinogen complex//membrane -- -- Cluster-4168.1 BF_2 1.00 0.74 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4193.2 BF_2 8.00 0.55 892 546678432 ERL89055.1 1407 4.1e-153 hypothetical protein D910_06433, partial [Dendroctonus ponderosae] 195028523 XM_001987090.1 145 9.76739e-68 Drosophila grimshawi GH20147 (Dgri\GH20147), mRNA K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 Q95ZS2 1077 3.1e-116 Tyrosine decarboxylase OS=Caenorhabditis elegans GN=tdc-1 PE=2 SV=1 PF00282 Pyridoxal-dependent decarboxylase conserved domain GO:0019752 carboxylic acid metabolic process GO:0016831//GO:0030170 carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-4221.1 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4222.0 BF_2 3.00 0.35 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4223.0 BF_2 11.00 0.69 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08992 Quinohemoprotein amine dehydrogenase, gamma subunit GO:0055114 oxidation-reduction process GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors -- -- -- -- Cluster-4229.0 BF_2 6.00 32.87 250 506439 CAA42628.1 282 3.2e-23 p53 transformation suppressor [Homo sapiens] 694965925 XM_001172077.3 250 1.05611e-126 PREDICTED: Pan troglodytes tumor protein p53 (TP53), mRNA K04451 TP53, P53 tumor protein p53 http://www.genome.jp/dbget-bin/www_bget?ko:K04451 P04637 282 1.3e-24 Cellular tumor antigen p53 OS=Homo sapiens GN=TP53 PE=1 SV=4 PF04625//PF00870 DEC-1 protein, N-terminal region//P53 DNA-binding domain GO:0007304 chorion-containing eggshell formation GO:0005213//GO:0044212 structural constituent of chorion//transcription regulatory region DNA binding GO:0005576//GO:0042600 extracellular region//chorion -- -- Cluster-4236.0 BF_2 3.00 0.36 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4239.0 BF_2 3.00 0.88 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4241.0 BF_2 2.00 1.10 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4244.0 BF_2 3.00 0.39 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4246.0 BF_2 10.00 3.33 412 795161082 XP_011796680.1 329 1.9e-28 PREDICTED: serine/threonine-protein kinase B-raf [Colobus angolensis palliatus] 823674701 KR712180.1 329 2.23888e-170 Synthetic construct Homo sapiens clone CCSBHm_00036663 BRAF (BRAF) mRNA, encodes complete protein K04365 BRAF B-Raf proto-oncogene serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04365 P15056 329 7.8e-30 Serine/threonine-protein kinase B-raf OS=Homo sapiens GN=BRAF PE=1 SV=4 PF02196//PF02465 Raf-like Ras-binding domain//Flagellar hook-associated protein 2 N-terminus GO:0007165 signal transduction GO:0005057 receptor signaling protein activity GO:0009424 bacterial-type flagellum hook -- -- Cluster-4248.0 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4249.0 BF_2 1.00 0.38 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4252.0 BF_2 3.00 0.76 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4264.0 BF_2 5.00 123.48 212 -- -- -- -- -- 24060020 AP004988.3 115 9.74416e-52 Oryza sativa Japonica Group genomic DNA, chromosome 7, BAC clone:B1056G08 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4268.1 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4271.0 BF_2 14.00 3.07 478 831778851 XP_012755537.1 256 6.4e-20 hypothetical protein SAMD00019534_045930 [Acytostelium subglobosum LB1]>gi|831787628|ref|XP_012758491.1| hypothetical protein SAMD00019534_010700 [Acytostelium subglobosum LB1]>gi|735856169|dbj|GAM21418.1| hypothetical protein SAMD00019534_045930 [Acytostelium subglobosum LB1]>gi|735859123|dbj|GAM17895.1| hypothetical protein SAMD00019534_010700 [Acytostelium subglobosum LB1] 347660620 BT130973.1 478 0 Oryza sativa clone RRlibB00185 mRNA sequence K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 P35687 425 6.6e-41 40S ribosomal protein S21 OS=Oryza sativa subsp. japonica GN=RPS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-4282.0 BF_2 2.00 0.35 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4289.0 BF_2 13.51 12.10 325 -- -- -- -- -- 119710194 DQ490951.2 319 6.24804e-165 Zea mays subsp. mays genotype CMS-S mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4293.0 BF_2 4.00 0.50 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4300.0 BF_2 7.00 2.04 430 313237817 CBY12950.1 260 2.0e-20 unnamed protein product [Oikopleura dioica] 115446384 NM_001053507.1 430 0 Oryza sativa Japonica Group Os02g0519900 (Os02g0519900) mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 O23755 339 5.6e-31 Elongation factor 2 OS=Beta vulgaris PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0469 Elongation factor 2 Cluster-4303.0 BF_2 2.00 1.65 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4304.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01991 ATP synthase (E/31 kDa) subunit GO:0015991//GO:0015992//GO:0006119 ATP hydrolysis coupled proton transport//proton transport//oxidative phosphorylation GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-4309.0 BF_2 8.00 7.54 322 874452899 XP_012948043.1 203 6.0e-14 PREDICTED: ALK tyrosine kinase receptor isoform X3 [Anas platyrhynchos] 221554531 NG_009445.1 322 1.32913e-166 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 P97793 203 2.5e-15 ALK tyrosine kinase receptor OS=Mus musculus GN=Alk PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1095 Protein tyrosine kinase Cluster-4310.1 BF_2 4.00 0.45 657 180195 AAA58419.1 316 9.7e-27 caldesmon [Homo sapiens]>gi|119604237|gb|EAW83831.1| caldesmon 1, isoform CRA_f [Homo sapiens] 767948780 XM_006716139.2 657 0 PREDICTED: Homo sapiens caldesmon 1 (CALD1), transcript variant X12, mRNA K12327 CALD1 caldesmon http://www.genome.jp/dbget-bin/www_bget?ko:K12327 Q05682 316 4.0e-28 Caldesmon OS=Homo sapiens GN=CALD1 PE=1 SV=3 PF00749//PF06459 tRNA synthetases class I (E and Q), catalytic domain//Ryanodine Receptor TM 4-6 GO:0043039//GO:0006874//GO:0044699//GO:0006816 tRNA aminoacylation//cellular calcium ion homeostasis//single-organism process//calcium ion transport GO:0016876//GO:0005219//GO:0008092//GO:0005524 ligase activity, forming aminoacyl-tRNA and related compounds//ryanodine-sensitive calcium-release channel activity//cytoskeletal protein binding//ATP binding GO:0005622//GO:0015629//GO:0044444//GO:0016021//GO:0071944 intracellular//actin cytoskeleton//cytoplasmic part//integral component of membrane//cell periphery -- -- Cluster-4312.1 BF_2 3.00 0.54 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4313.0 BF_2 4.00 0.42 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4315.0 BF_2 3.00 0.71 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912 C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-4315.1 BF_2 31.00 0.51 2820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08118 Yeast mitochondrial distribution and morphology (MDM) proteins GO:0007005 mitochondrion organization -- -- GO:0005743 mitochondrial inner membrane -- -- Cluster-4320.0 BF_2 3.00 0.33 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4323.0 BF_2 6.00 0.80 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4332.0 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4333.0 BF_2 3.00 0.40 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4337.0 BF_2 4.00 0.39 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4338.0 BF_2 3.00 0.41 596 270016092 EFA12540.1 180 5.2e-11 hypothetical protein TcasGA2_TC016065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4341.0 BF_2 1.00 0.53 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4342.0 BF_2 2.00 1.24 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4344.0 BF_2 6.00 0.74 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4352.0 BF_2 2.00 0.59 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4360.0 BF_2 3.00 0.33 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4362.0 BF_2 4.00 0.43 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4370.0 BF_2 5.00 1.25 454 694939762 XP_009456686.1 541 5.4e-53 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret [Pan troglodytes] 336042955 JF276429.1 451 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 344 1.6e-31 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-4371.0 BF_2 6.00 1.44 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q941C5 125 3.9e-06 CLAVATA3/ESR (CLE)-related protein 44 OS=Arabidopsis thaliana GN=CLE44 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4373.0 BF_2 3.00 0.57 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07829 Alpha-A conotoxin PIVA-like protein GO:0007165//GO:0009405//GO:0007268 signal transduction//pathogenesis//synaptic transmission GO:0030550 acetylcholine receptor inhibitor activity GO:0005576 extracellular region -- -- Cluster-4375.0 BF_2 5.00 0.88 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4376.0 BF_2 3.00 0.40 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4382.0 BF_2 12.00 2.28 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4383.0 BF_2 7.00 3.79 361 -- -- -- -- -- 150171635 CU406071.1 361 0 Oryza rufipogon (W1943) cDNA clone: ORW1943C112J17, full insert sequence -- -- -- -- P45434 190 8.9e-14 Translocon-associated protein subunit alpha OS=Arabidopsis thaliana GN=At2g21160 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-4386.0 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4391.1 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4392.0 BF_2 4.00 0.61 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4395.0 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4399.0 BF_2 1.00 0.90 325 861588173 KMQ82585.1 166 1.2e-09 transposase-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4402.0 BF_2 1.00 0.43 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4403.0 BF_2 3.00 0.89 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4406.0 BF_2 3.00 0.57 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4407.0 BF_2 9.00 269.16 208 -- -- -- -- -- 57164409 AC118132.3 205 8.87688e-102 Oryza sativa Japonica Group chromosome 3 clone OSJNBa0003A09, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4408.0 BF_2 5.00 1.24 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4409.0 BF_2 25.00 1.71 898 397513795 XP_003827193.1 1040 1.5e-110 PREDICTED: ALK tyrosine kinase receptor [Pan paniscus] 221554531 NG_009445.1 878 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 1036 1.8e-111 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-4410.1 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4412.0 BF_2 6.00 1.53 451 221120117 XP_002160755.1 163 3.7e-09 PREDICTED: copper transport protein ATOX1 homolog [Hydra vulgaris] 725812573 KM434244.1 137 1.33284e-63 Populus simonii x Populus nigra ATX2 (ATX2) mRNA, complete cds -- -- -- -- O82089 316 2.7e-28 Copper transport protein CCH OS=Arabidopsis thaliana GN=CCH PE=1 SV=1 PF03776//PF16517//PF00403 Septum formation topological specificity factor MinE//Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain//Heavy-metal-associated domain GO:0051301//GO:0030001//GO:0007165//GO:0032955 cell division//metal ion transport//signal transduction//regulation of barrier septum assembly GO:0046872 metal ion binding -- -- -- -- Cluster-4415.0 BF_2 3.00 1.13 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4417.0 BF_2 22.00 84.82 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4426.0 BF_2 1.00 0.80 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4432.0 BF_2 6.00 0.39 935 -- -- -- -- -- 827475666 NG_042174.1 935 0 Homo sapiens secreted protein, acidic, cysteine-rich (osteonectin) (SPARC), RefSeqGene on chromosome 5 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4435.0 BF_2 7.00 0.95 594 -- -- -- -- -- 597591659 KJ193893.1 87 1.11302e-35 Corylus avellana microsatellite BR267 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4447.0 BF_2 3.00 1.75 355 194318458 ACF47617.1 542 3.3e-53 soluble MET variant 15 [Homo sapiens] 212720875 NG_008996.1 351 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2IBA6 509 9.0e-51 Hepatocyte growth factor receptor OS=Chlorocebus aethiops GN=MET PE=3 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- KOG3610 Plexins (functional semaphorin receptors) Cluster-4450.0 BF_2 6.00 0.71 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07964 Rec10 / Red1 GO:0007131//GO:0051598 reciprocal meiotic recombination//meiotic recombination checkpoint GO:0005198 structural molecule activity -- -- -- -- Cluster-4452.0 BF_2 7.00 0.37 1075 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4453.0 BF_2 5.00 1.12 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4456.0 BF_2 2.00 0.39 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4462.0 BF_2 3.00 0.41 590 817294760 XP_012317796.1 1061 3.6e-113 PREDICTED: integrin alpha-6 isoform X1 [Aotus nancymaae] 649119510 KJ897063.1 590 0 Synthetic construct Homo sapiens clone ccsbBroadEn_06457 ITGA6 gene, encodes complete protein K06485 ITGA6 integrin alpha 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06485 Q61739 1049 3.6e-113 Integrin alpha-6 OS=Mus musculus GN=Itga6 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-4464.0 BF_2 6.00 0.57 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03930 Recombinase Flp protein N-terminus GO:0006310 DNA recombination -- -- -- -- -- -- Cluster-4465.0 BF_2 2.00 0.43 483 -- -- -- -- -- 828286610 XM_004485536.2 123 8.69707e-56 PREDICTED: Cicer arietinum protein EXORDIUM-like 2 (LOC101490191), mRNA -- -- -- -- Q9FE06 613 1.1e-62 Protein EXORDIUM-like 2 OS=Arabidopsis thaliana GN=EXL2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4466.2 BF_2 17.81 0.56 1627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4468.0 BF_2 1.00 0.39 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4471.0 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4472.0 BF_2 4.00 0.47 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4473.0 BF_2 2.00 0.34 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4475.0 BF_2 4.00 0.54 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4476.0 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4483.0 BF_2 11.17 0.82 856 270006486 EFA02934.1 159 2.0e-08 gustatory receptor 101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0050909//GO:0007187//GO:0050912//GO:0007607 sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-4485.0 BF_2 27.81 1.16 1290 501595189 YP_007890635.1 1741 1.1e-191 NADH dehydrogenase subunit 7 (mitochondrion) [Jakoba bahamiensis]>gi|462269339|gb|AGH24129.1| NADH dehydrogenase subunit 7 (mitochondrion) [Jakoba bahamiensis] 87248043 DQ381459.1 1116 0 Beta vulgaris subsp. vulgaris NADH dehydrogenase subunit 7 (nad7) mRNA, complete cds; mitochondrial K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q36450 1849 1.4e-205 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 OS=Nicotiana sylvestris GN=NAD7 PE=2 SV=1 PF00374//PF00346 Nickel-dependent hydrogenase//Respiratory-chain NADH dehydrogenase, 49 Kd subunit GO:0055114 oxidation-reduction process GO:0051287//GO:0016151//GO:0048038//GO:0016651 NAD binding//nickel cation binding//quinone binding//oxidoreductase activity, acting on NAD(P)H -- -- KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-4487.0 BF_2 10.00 3.25 415 831499220 XP_012710011.1 205 4.6e-14 PREDICTED: fibroblast growth factor receptor 2-like [Fundulus heteroclitus] 254553324 NG_012449.1 415 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 203 3.2e-15 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4488.0 BF_2 8.00 4.33 361 119569728 EAW49343.1 366 8.5e-33 fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome), isoform CRA_e [Homo sapiens]>gi|119569737|gb|EAW49352.1| fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome), isoform CRA_e [Homo sapiens]>gi|119569741|gb|EAW49356.1| fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome), isoform CRA_e [Homo sapiens] 254553324 NG_012449.1 361 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 352 1.5e-32 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 -- -- GO:0021847//GO:0001525//GO:0007528//GO:0060463//GO:0046777//GO:0048286//GO:0055010//GO:0003149//GO:0045839//GO:0040036//GO:0060484//GO:0090263//GO:0051781//GO:0060174//GO:0002053//GO:0060045//GO:0009791//GO:0030901//GO:0070307//GO:0060527//GO:0030282//GO:0033688//GO:0010453//GO:0001657//GO:0035602//GO:0060529//GO:0060449//GO:0009880//GO:0035607//GO:0000122//GO:0060664//GO:0060595//GO:0060349//GO:0048557//GO:0010518//GO:0045944//GO:0045667//GO:0060915//GO:0048489//GO:0051150//GO:0060523//GO:0003148//GO:0035603//GO:0070374//GO:0007409//GO:0060501//GO:0060615//GO:0032808//GO:0018108//GO:0060667//GO:0042476//GO:0061031//GO:0008286//GO:0060687//GO:0048755//GO:0040014//GO:0031069//GO:0060670//GO:0030916//GO:0060601//GO:0021860//GO:0060916//GO:0007169//GO:0008285//GO:0008589//GO:0035604//GO:0045787 ventricular zone neuroblast division//angiogenesis//neuromuscular junction development//lung lobe morphogenesis//protein autophosphorylation//lung alveolus development//ventricular cardiac muscle tissue morphogenesis//membranous septum morphogenesis//negative regulation of mitotic nuclear division//regulation of fibroblast growth factor receptor signaling pathway//lung-associated mesenchyme development//positive regulation of canonical Wnt signaling pathway//positive regulation of cell division//limb bud formation//positive regulation of mesenchymal cell proliferation//positive regulation of cardiac muscle cell proliferation//post-embryonic development//midbrain development//lens fiber cell development//prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis//bone mineralization//regulation of osteoblast proliferation//regulation of cell fate commitment//ureteric bud development//fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow//squamous basal epithelial stem cell differentiation involved in prostate gland acinus development//bud elongation involved in lung branching//embryonic pattern specification//fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development//negative regulation of transcription from RNA polymerase II promoter//epithelial cell proliferation involved in salivary gland morphogenesis//fibroblast growth factor receptor signaling pathway involved in mammary gland specification//bone morphogenesis//embryonic digestive tract morphogenesis//positive regulation of phospholipase activity//positive regulation of transcription from RNA polymerase II promoter//regulation of osteoblast differentiation//mesenchymal cell differentiation involved in lung development//synaptic vesicle transport//regulation of smooth muscle cell differentiation//prostate epithelial cord elongation//outflow tract septum morphogenesis//fibroblast growth factor receptor signaling pathway involved in hemopoiesis//positive regulation of ERK1 and ERK2 cascade//axonogenesis//positive regulation of epithelial cell proliferation involved in lung morphogenesis//mammary gland bud formation//lacrimal gland development//peptidyl-tyrosine phosphorylation//branch elongation involved in salivary gland morphogenesis//odontogenesis//endodermal digestive tract morphogenesis//insulin receptor signaling pathway//regulation of branching involved in prostate gland morphogenesis//branching morphogenesis of a nerve//regulation of multicellular organism growth//hair follicle morphogenesis//branching involved in labyrinthine layer morphogenesis//otic vesicle formation//lateral sprouting from an epithelium//pyramidal neuron development//mesenchymal cell proliferation involved in lung development//transmembrane receptor protein tyrosine kinase signaling pathway//negative regulation of cell proliferation//regulation of smoothened signaling pathway//fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow//positive regulation of cell cycle GO:0008201//GO:0042803//GO:0005007//GO:0005524//GO:0017134 heparin binding//protein homodimerization activity//fibroblast growth factor-activated receptor activity//ATP binding//fibroblast growth factor binding GO:0005938//GO:0005634//GO:0060076//GO:0005794//GO:0031012//GO:0005887//GO:0005576//GO:0009986//GO:0016023 cell cortex//nucleus//excitatory synapse//Golgi apparatus//extracellular matrix//integral component of plasma membrane//extracellular region//cell surface//cytoplasmic membrane-bounded vesicle -- -- Cluster-4493.0 BF_2 11.00 1.66 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4500.0 BF_2 4.00 0.41 697 795279414 XP_011819957.1 269 2.9e-21 PREDICTED: insulin-like growth factor-binding protein 5 isoform X1 [Mandrillus leucophaeus] 171460920 NM_000599.3 694 0 Homo sapiens insulin-like growth factor binding protein 5 (IGFBP5), mRNA -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-4501.0 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0046813//GO:0061025 receptor-mediated virion attachment to host cell//membrane fusion -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-4502.0 BF_2 47.11 1.42 1678 91076754 XP_973519.1 1462 3.2e-159 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63564 350 1.2e-31 Synaptic vesicle glycoprotein 2B OS=Rattus norvegicus GN=Sv2b PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-4503.0 BF_2 6.00 0.83 589 700365745 XP_009927550.1 434 1.8e-40 PREDICTED: translationally-controlled tumor protein homolog, partial [Haliaeetus albicilla] 334854631 HQ640232.1 315 1.98658e-162 Hevea brasiliensis translationally controlled tumor protein (TCTP) mRNA, complete cds -- -- -- -- Q9ZSW9 584 3.0e-59 Translationally-controlled tumor protein homolog OS=Hevea brasiliensis GN=TCTP PE=2 SV=1 PF00183//PF00185 Hsp90 protein//Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain GO:0006520//GO:0006950//GO:0006457 cellular amino acid metabolic process//response to stress//protein folding GO:0016743//GO:0051082//GO:0016597//GO:0005524 carboxyl- or carbamoyltransferase activity//unfolded protein binding//amino acid binding//ATP binding -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-4512.0 BF_2 3.00 0.35 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4514.0 BF_2 9.00 1.88 487 470528558 XP_004367925.1 474 3.4e-45 ribosomal protein S8e, putative [Acanthamoeba castellanii str. Neff]>gi|440804293|gb|ELR25170.1| ribosomal protein S8e, putative [Acanthamoeba castellanii str. Neff] 156764932 AK288317.1 487 0 Oryza sativa Japonica Group cDNA, clone: J090021K08, full insert sequence K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 P49199 643 3.6e-66 40S ribosomal protein S8 OS=Oryza sativa subsp. japonica GN=RPS8 PE=2 SV=2 PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG3283 40S ribosomal protein S8 Cluster-4516.0 BF_2 1.00 0.41 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4518.0 BF_2 1.00 2.73 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4520.0 BF_2 3.00 0.31 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4522.0 BF_2 6.00 2.03 410 767943410 XP_011534358.1 335 3.8e-29 PREDICTED: proto-oncogene tyrosine-protein kinase ROS isoform X9 [Homo sapiens] 584458492 NG_033929.1 402 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 335 1.6e-30 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-4524.0 BF_2 15.00 1.34 756 -- -- -- -- -- 844622080 KM506577.1 145 8.21918e-68 Eriobotrya japonica transcription factor ERF11 (ERF11) mRNA, complete cds -- -- -- -- Q9LW49 245 7.8e-20 Ethylene-responsive transcription factor 4 OS=Nicotiana sylvestris GN=ERF4 PE=2 SV=1 PF00847 AP2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-4532.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4534.0 BF_2 2.00 0.73 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4535.0 BF_2 2.00 0.78 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05424 Duffy binding domain GO:0009405//GO:0007165 pathogenesis//signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-4538.0 BF_2 2.00 0.42 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4546.0 BF_2 6.00 0.35 1014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4548.0 BF_2 7.00 1.01 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4553.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4555.0 BF_2 1.00 0.31 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4556.0 BF_2 7.00 1.46 487 553832032 AGY61401.1 222 5.7e-16 30S ribosomal protein S14 [Lotharella sp. CCMP622] 761231940 KM881643.1 487 0 Oryza officinalis chloroplast, complete genome -- -- -- -- P0C467 463 2.7e-45 30S ribosomal protein S14, chloroplastic OS=Oryza sativa subsp. japonica GN=rps14 PE=3 SV=1 PF00253 Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1741 Mitochondrial/chloroplast ribosomal protein S14/S29 Cluster-4560.0 BF_2 3.00 0.46 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4564.0 BF_2 6.00 0.45 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4568.0 BF_2 2.00 0.63 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4573.0 BF_2 7.00 0.42 983 166795236 NP_002344.2 677 2.0e-68 tumor-associated calcium signal transducer 2 precursor [Homo sapiens]>gi|397507576|ref|XP_003824268.1| PREDICTED: tumor-associated calcium signal transducer 2 [Pan paniscus]>gi|160113102|sp|P09758.3|TACD2_HUMAN RecName: Full=Tumor-associated calcium signal transducer 2; AltName: Full=Cell surface glycoprotein Trop-2; AltName: Full=Membrane component chromosome 1 surface marker 1; AltName: Full=Pancreatic carcinoma marker protein GA733-1; Flags: Precursor>gi|31591|emb|CAA31781.1| unnamed protein product [Homo sapiens]>gi|11414806|emb|CAA54801.1| gp50/TROP-2 [Homo sapiens]>gi|14495611|gb|AAH09409.1| Tumor-associated calcium signal transducer 2 [Homo sapiens]>gi|30583349|gb|AAP35919.1| tumor-associated calcium signal transducer 2 [Homo sapiens]>gi|60818801|gb|AAX36477.1| tumor-associated calcium signal transducer 2 [synthetic construct]>gi|61362799|gb|AAX42283.1| tumor-associated calcium signal transducer 2 [synthetic construct]>gi|61363030|gb|AAX42322.1| tumor-associated calcium signal transducer 2 [synthetic construct]>gi|123984363|gb|ABM83527.1| tumor-associated calcium signal transducer 2 [synthetic construct]>gi|123998319|gb|ABM86761.1| tumor-associated calcium signal transducer 2 [synthetic construct] 281485551 NG_016237.1 983 0 Homo sapiens tumor-associated calcium signal transducer 2 (TACSTD2), RefSeqGene on chromosome 1 K17288 TACSTD2 tumor-associated calcium signal transducer 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17288 P09758 677 8.2e-70 Tumor-associated calcium signal transducer 2 OS=Homo sapiens GN=TACSTD2 PE=1 SV=3 PF05454 Dystroglycan (Dystrophin-associated glycoprotein 1) GO:0007016//GO:0007165//GO:0007601//GO:0050678//GO:0090191//GO:0007166//GO:0010633//GO:1900025//GO:1900028//GO:0051497 cytoskeletal anchoring at plasma membrane//signal transduction//visual perception//regulation of epithelial cell proliferation//negative regulation of branching involved in ureteric bud morphogenesis//cell surface receptor signaling pathway//negative regulation of epithelial cell migration//negative regulation of substrate adhesion-dependent cell spreading//negative regulation of ruffle assembly//negative regulation of stress fiber assembly GO:0004872 receptor activity GO:0005887//GO:0005829//GO:0016010//GO:0016328//GO:0009925 integral component of plasma membrane//cytosol//dystrophin-associated glycoprotein complex//lateral plasma membrane//basal plasma membrane -- -- Cluster-4575.0 BF_2 18.00 1.27 879 569384271 ETO16318.1 175 2.9e-10 hypothetical protein RFI_21034 [Reticulomyxa filosa] 823149956 XM_012619360.1 278 1.11907e-141 PREDICTED: Gossypium raimondii B2 protein-like (LOC105791332), mRNA -- -- -- -- P37707 756 5.1e-79 B2 protein OS=Daucus carota PE=2 SV=1 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-4576.0 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4580.0 BF_2 3.00 0.48 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4581.0 BF_2 2.00 4.21 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4584.0 BF_2 45.00 14.30 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09496 Cenp-O kinetochore centromere component GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-4588.0 BF_2 3.00 0.40 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4593.0 BF_2 3.00 0.40 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4597.0 BF_2 2.00 0.36 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4608.0 BF_2 7.00 2.18 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4613.0 BF_2 2.00 0.63 420 -- -- -- -- -- 685843856 LN608008.1 420 0 TPA: Homo sapiens long non-coding RNA OTTHUMT00000364577.2 (C4orf3 gene), lincRNA -- -- -- -- Q8WVX3 130 9.4e-07 Uncharacterized protein C4orf3 OS=Homo sapiens GN=C4orf3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-4614.0 BF_2 1.00 0.43 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4616.1 BF_2 5.00 0.36 871 752863744 XP_011268239.1 339 2.8e-29 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] 60649821 AJ829764.1 332 1.0624e-171 Otiorhynchus sulcatus partial cbh1 gene for cellulose 1,4-beta-cellobiosidase, six exons -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-4618.0 BF_2 2.00 0.32 547 642923122 XP_008193618.1 371 3.4e-33 PREDICTED: cyclic nucleotide-gated cation channel beta-1 [Tribolium castaneum]>gi|270007574|gb|EFA04022.1| hypothetical protein TcasGA2_TC014251 [Tribolium castaneum] -- -- -- -- -- K04948 CNGA1 cyclic nucleotide gated channel alpha 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04948 Q00194 247 3.3e-20 cGMP-gated cation channel alpha-1 OS=Bos taurus GN=CNGA1 PE=1 SV=1 -- -- GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016021 integral component of membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-4623.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4624.0 BF_2 7.00 0.49 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4625.0 BF_2 3.00 0.46 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4627.0 BF_2 2.00 0.39 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4631.0 BF_2 9.00 2.59 432 821008071 XP_012366882.1 242 2.4e-18 PREDICTED: discoidin domain-containing receptor 2 isoform X1 [Nomascus leucogenys] 282721095 NG_016290.1 429 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 242 1.0e-19 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-4638.0 BF_2 6.00 0.36 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4638.1 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4638.2 BF_2 2.00 0.35 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12639 DNase/tRNase domain of colicin-like bacteriocin -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-4639.0 BF_2 10.00 1.05 687 6006555 CAB56793.1 445 1.1e-41 proto-oncogene [Homo sapiens] 212720875 NG_008996.1 517 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2IBF2 445 4.6e-43 Hepatocyte growth factor receptor OS=Gorilla gorilla gorilla GN=MET PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4640.0 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4641.0 BF_2 3.00 0.86 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4645.0 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4648.0 BF_2 3.00 0.60 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4650.0 BF_2 2.00 0.32 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4651.0 BF_2 3.00 1.81 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4652.0 BF_2 5.00 0.59 639 642921874 XP_008192925.1 139 3.2e-06 PREDICTED: LIM domain-containing protein jub isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4656.0 BF_2 11.00 7.19 346 470248792 XP_004357939.1 333 5.5e-29 cyclophilin-type peptidylprolyl cis-trans isomerase [Dictyostelium fasciculatum]>gi|328871274|gb|EGG19645.1| cyclophilin-type peptidylprolyl cis-trans isomerase [Dictyostelium fasciculatum] 347660579 BT130932.1 343 3.05055e-178 Oryza sativa clone RRlibC00386 mRNA sequence K05864 PPID, CYPD peptidyl-prolyl isomerase D http://www.genome.jp/dbget-bin/www_bget?ko:K05864 P21569 377 1.8e-35 Peptidyl-prolyl cis-trans isomerase OS=Zea mays GN=CYP PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- -- -- Cluster-4657.0 BF_2 2.00 0.92 376 662033881 NP_001284494.1 340 9.2e-30 cytochrome b-c1 complex subunit 6, mitochondrial isoform 2 precursor [Homo sapiens]>gi|675669935|ref|XP_008999404.1| PREDICTED: cytochrome b-c1 complex subunit 6, mitochondrial isoform X2 [Callithrix jacchus]>gi|62202498|gb|AAH93060.1| UQCRH protein [Homo sapiens]>gi|119627330|gb|EAX06925.1| ubiquinol-cytochrome c reductase hinge protein, isoform CRA_c [Homo sapiens] 662033880 NM_001297565.1 376 0 Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), transcript variant 2, mRNA K00416 QCR6, UQCRH ubiquinol-cytochrome c reductase subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00416 P07919 340 3.8e-31 Cytochrome b-c1 complex subunit 6, mitochondrial OS=Homo sapiens GN=UQCRH PE=1 SV=2 -- -- GO:0006119//GO:0044281//GO:0006122//GO:0009060//GO:0015992//GO:0006118//GO:0051291 oxidative phosphorylation//small molecule metabolic process//mitochondrial electron transport, ubiquinol to cytochrome c//aerobic respiration//proton transport//obsolete electron transport//protein heterooligomerization GO:0008121//GO:0032403 ubiquinol-cytochrome-c reductase activity//protein complex binding GO:0005750 mitochondrial respiratory chain complex III -- -- Cluster-4660.0 BF_2 22.00 1.76 811 820994700 XP_012363844.1 310 5.9e-26 PREDICTED: LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [Nomascus leucogenys] 188219627 NG_007729.1 808 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P16092 219 8.7e-17 Fibroblast growth factor receptor 1 OS=Mus musculus GN=Fgfr1 PE=1 SV=2 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-4662.0 BF_2 5.00 0.71 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4663.0 BF_2 3.00 0.70 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4664.0 BF_2 14.00 4.52 416 700346190 XP_009917077.1 246 8.0e-19 PREDICTED: elongation factor 1-alpha 1, partial [Haliaeetus albicilla] 157502238 AC210917.1 410 0 Oryza glaberrima clone OG_BBa0029F18, complete sequence K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 O64937 279 4.9e-24 Elongation factor 1-alpha OS=Oryza sativa subsp. japonica GN=REFA1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-4667.0 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4669.0 BF_2 17.00 1.23 865 347597921 AEP14559.1 394 1.2e-35 aquaporin 5 [Milnesium tardigradum] 28395417 AY189973.1 623 0 Juglans regia plasma intrinsic protein 2,1 mRNA, complete cds K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q9FF53 946 4.6e-101 Probable aquaporin PIP2-4 OS=Arabidopsis thaliana GN=PIP2-4 PE=1 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-4671.0 BF_2 17.00 2.36 588 -- -- -- -- -- 119395179 EF122464.1 573 0 Oryza sativa (japonica cultivar-group) clone KCS337A09 glutelin mRNA, complete cds -- -- -- -- P14614 642 5.7e-66 Glutelin type-B 4 OS=Oryza sativa subsp. japonica GN=GLUB4 PE=1 SV=1 PF00190//PF03931 Cupin//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0045735 nutrient reservoir activity -- -- -- -- Cluster-4672.0 BF_2 8.00 4.43 359 -- -- -- -- -- 60391308 D50017.2 359 0 Homo sapiens PDGFRA gene for alpha-platelet-derived growth factor receptor, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4673.0 BF_2 1.00 1.19 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02160 Cauliflower mosaic virus peptidase (A3) GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-4674.0 BF_2 28.00 2.46 763 676468049 XP_009058083.1 291 8.9e-24 hypothetical protein LOTGIDRAFT_228827 [Lottia gigantea]>gi|556102740|gb|ESO91392.1| hypothetical protein LOTGIDRAFT_228827 [Lottia gigantea] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9LSF8 608 6.4e-62 Cytochrome P450 82G1 OS=Arabidopsis thaliana GN=CYP82G1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-4677.0 BF_2 32.00 1.39 1253 281204156 EFA78352.1 1095 8.7e-117 hydroxymethylglutaryl CoA reductase [Polysphondylium pallidum PN500] 144952795 EF206343.1 561 0 Corylus avellana 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA, complete cds K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 O64967 1462 9.9e-161 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 OS=Gossypium hirsutum GN=HMG2 PE=3 SV=1 PF00368 Hydroxymethylglutaryl-coenzyme A reductase GO:0015936//GO:0055114//GO:0006694 coenzyme A metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0004420//GO:0050662 hydroxymethylglutaryl-CoA reductase (NADPH) activity//coenzyme binding -- -- KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-4682.0 BF_2 15.00 1.45 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P00303 396 2.3e-37 Basic blue protein OS=Cucumis sativus PE=1 SV=1 PF02298//PF06525 Plastocyanin-like domain//Sulfocyanin (SoxE) domain GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005507//GO:0009055 copper ion binding//electron carrier activity -- -- -- -- Cluster-4687.0 BF_2 5.00 2.14 383 183881 AAA35959.1 385 5.6e-35 heparin-binding growth factor receptor [Homo sapiens] 188219627 NG_007729.1 383 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 Q04589 340 3.8e-31 Fibroblast growth factor receptor 1 OS=Rattus norvegicus GN=Fgfr1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-4695.0 BF_2 9.00 1.20 601 556985480 XP_005998462.1 306 1.3e-25 PREDICTED: elongation factor 1-beta [Latimeria chalumnae] 149391280 EF576070.1 601 0 Oryza sativa (indica cultivar-group) clone OSE-577-637-E3 elongation factor beta-1 mRNA, complete cds K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P29545 442 9.0e-43 Elongation factor 1-beta OS=Oryza sativa subsp. japonica GN=Os07g0662500 PE=1 SV=3 PF00736 EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840//GO:0005853 ribosome//eukaryotic translation elongation factor 1 complex KOG1668 Elongation factor 1 beta/delta chain Cluster-4700.0 BF_2 3.00 0.55 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4707.0 BF_2 3.00 0.40 604 222543956 ACM66845.1 194 1.3e-12 nuclear autoantigenic sperm protein [Penaeus monodon] -- -- -- -- -- K11291 NASP nuclear autoantigenic sperm protein http://www.genome.jp/dbget-bin/www_bget?ko:K11291 Q2T9P4 157 1.0e-09 Nuclear autoantigenic sperm protein OS=Bos taurus GN=NASP PE=2 SV=2 PF13181//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-4710.0 BF_2 4.00 0.61 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4713.0 BF_2 7.00 3.31 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4714.0 BF_2 3.00 0.48 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4716.0 BF_2 9.00 3.39 397 -- -- -- -- -- 285026150 AP011077.1 397 0 Oryza sativa Indica Group mitochondrial DNA, complete genome, cultivar: Lead rice -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4720.0 BF_2 11.00 2.96 442 847013788 XP_012804286.1 196 5.4e-13 PREDICTED: LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [Jaculus jaculus] 219521916 NG_009250.1 442 0 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), RefSeqGene (LRG_309) on chromosome 4 K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 P20786 191 8.4e-14 Platelet-derived growth factor receptor alpha OS=Rattus norvegicus GN=Pdgfra PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-4721.0 BF_2 8.00 1.00 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02939 UcrQ family GO:0006118//GO:0006119//GO:0015992 obsolete electron transport//oxidative phosphorylation//proton transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-4722.0 BF_2 15.00 1.00 914 308445919 XP_003087050.1 464 9.3e-44 hypothetical protein CRE_25058 [Caenorhabditis remanei]>gi|308264385|gb|EFP08338.1| hypothetical protein CRE_25058 [Caenorhabditis remanei] 566192938 XM_002317168.2 211 2.04916e-104 Populus trichocarpa hypothetical protein (POPTR_0011s00530g) mRNA, complete cds K01696 trpB tryptophan synthase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01696 O50046 614 1.5e-62 Tryptophan synthase beta chain 2, chloroplastic OS=Camptotheca acuminata GN=TSB PE=2 SV=1 -- -- GO:0006568 tryptophan metabolic process -- -- -- -- KOG1395 Tryptophan synthase beta chain Cluster-4725.0 BF_2 4.00 0.38 730 148680533 EDL12480.1 842 1.1e-87 eukaryotic translation initiation factor 5A, isoform CRA_d, partial [Mus musculus] 219555708 NM_001970.4 730 0 Homo sapiens eukaryotic translation initiation factor 5A (EIF5A), transcript variant B, mRNA K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 Q6EWQ7 797 7.5e-84 Eukaryotic translation initiation factor 5A-1 OS=Bos taurus GN=EIF5A PE=2 SV=3 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006452//GO:0006448//GO:0045905//GO:0045901 translational frameshifting//regulation of translational elongation//positive regulation of translational termination//positive regulation of translational elongation GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-4726.0 BF_2 5.00 0.87 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4729.0 BF_2 2.00 0.37 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4732.0 BF_2 2.00 0.32 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4733.0 BF_2 6.00 0.92 559 829944637 XP_012598516.1 578 3.4e-57 PREDICTED: uncharacterized protein LOC105859346 [Microcebus murinus] 675714108 XM_003811634.2 559 0 PREDICTED: Pan paniscus small ubiquitin-related modifier 2 (LOC100994911), mRNA K12160 SUMO, SMT3 small ubiquitin-related modifier http://www.genome.jp/dbget-bin/www_bget?ko:K12160 P61955 488 3.9e-48 Small ubiquitin-related modifier 2 OS=Bos taurus GN=SUMO2 PE=3 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-4734.0 BF_2 1.00 0.69 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4744.0 BF_2 2.00 1.01 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4746.0 BF_2 2.00 0.35 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4756.0 BF_2 5.00 1.28 450 115443537 YP_778556.1 266 4.2e-21 ATP synthase CF0 A chain [Bigelowiella natans]>gi|122239927|sp|Q06J71.1|ATPI_BIGNA RecName: Full=ATP synthase subunit a, chloroplastic; AltName: Full=ATP synthase F0 sector subunit a; AltName: Full=F-ATPase subunit IV (chloroplast) [Bigelowiella natans]>gi|110810182|gb|ABG91388.1| ATP synthase CF0 A chain [Bigelowiella natans] 761231856 KM881642.1 450 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C2Y5 309 1.8e-27 ATP synthase subunit a, chloroplastic OS=Oryza sativa GN=atpI PE=3 SV=1 PF00119 ATP synthase A chain GO:0015986//GO:0015992//GO:0006754 ATP synthesis coupled proton transport//proton transport//ATP biosynthetic process GO:0015078 hydrogen ion transmembrane transporter activity GO:0009507//GO:0044425//GO:0009579 chloroplast//membrane part//thylakoid -- -- Cluster-4758.0 BF_2 2.00 0.52 447 645041401 XP_008206546.1 250 3.0e-19 PREDICTED: uncharacterized protein LOC103315298, partial [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4762.0 BF_2 3.00 0.53 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4764.0 BF_2 5.00 2.39 372 545804908 XP_005660589.1 202 9.1e-14 PREDICTED: uncharacterized protein LOC100737022 [Sus scrofa] 2599243 AC002096.1 372 0 AC002096 Homo sapiens chromosome 9q34, clone 63G10, complete sequence K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q92574 198 1.1e-14 Hamartin OS=Homo sapiens GN=TSC1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-4765.0 BF_2 3.00 3.20 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4767.0 BF_2 285.00 390.82 302 -- -- -- -- -- 527047448 HG323741.1 299 7.55182e-154 TPA: Oryza sativa Japonica Group SRP RNA for signal recognition particle RNA >gnl|BL_ORD_ID|15308895 TPA: Oryza sativa Japonica Group SRP RNA for signal recognition particle RNA -- -- -- -- -- -- -- -- PF07473 Spasmodic peptide gm9a; conotoxin from Conus species GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-4772.1 BF_2 4.00 2.51 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4773.0 BF_2 10.00 0.51 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4777.0 BF_2 6.00 0.58 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4780.0 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4807.0 BF_2 39.00 2.52 934 478256984 ENN77148.1 165 4.5e-09 hypothetical protein YQE_06287, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4813.0 BF_2 19.00 1.57 792 642919108 XP_008191740.1 256 1.1e-19 PREDICTED: uncharacterized protein LOC103312569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4813.2 BF_2 16.02 0.96 985 91084407 XP_967001.1 549 1.4e-53 PREDICTED: uncharacterized protein LOC655368 [Tribolium castaneum]>gi|270008706|gb|EFA05154.1| hypothetical protein TcasGA2_TC015272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4823.0 BF_2 2.00 1.14 357 -- -- -- -- -- 255566625 XM_002524251.1 122 2.25218e-55 Ricinus communis Abscisic stress ripening protein, putative, mRNA -- -- -- -- Q08655 141 4.2e-08 Abscisic stress-ripening protein 1 OS=Solanum lycopersicum GN=ASR1 PE=2 SV=1 PF02990//PF02496 Endomembrane protein 70//ABA/WDS induced protein GO:0006950 response to stress -- -- GO:0016021 integral component of membrane -- -- Cluster-4825.0 BF_2 8.00 0.83 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4831.0 BF_2 8.22 0.33 1324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4832.0 BF_2 10.00 2.76 438 344280465 XP_003412004.1 198 3.1e-13 PREDICTED: ALK tyrosine kinase receptor [Loxodonta africana] 221554531 NG_009445.1 438 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 195 2.9e-14 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-4834.0 BF_2 1.00 0.66 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4837.0 BF_2 4.00 0.46 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4839.0 BF_2 6.00 0.75 623 820970032 XP_012356169.1 878 6.3e-92 PREDICTED: annexin A1 isoform X2 [Nomascus leucogenys] 733606737 NM_000700.2 618 0 Homo sapiens annexin A1 (ANXA1), mRNA K17091 ANXA1 annexin A1 http://www.genome.jp/dbget-bin/www_bget?ko:K17091 P04083 852 2.7e-90 Annexin A1 OS=Homo sapiens GN=ANXA1 PE=1 SV=2 PF08587//PF00191 Ubiquitin associated domain (UBA)//Annexin GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0005544//GO:0004674//GO:0005509 calcium-dependent phospholipid binding//protein serine/threonine kinase activity//calcium ion binding -- -- -- -- Cluster-4844.0 BF_2 18.09 1.40 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF03534 Septum formation initiator//Salmonella virulence plasmid 65kDa B protein GO:0007049 cell cycle -- -- GO:0005737 cytoplasm -- -- Cluster-4844.1 BF_2 7.91 0.52 918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF01635 Septum formation initiator//Coronavirus M matrix/glycoprotein GO:0007049//GO:0019058 cell cycle//viral life cycle -- -- -- -- -- -- Cluster-4848.0 BF_2 5.00 0.33 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09260 Domain of unknown function (DUF1966) GO:0016052//GO:0005982//GO:0005985 carbohydrate catabolic process//starch metabolic process//sucrose metabolic process GO:0005509//GO:0004556 calcium ion binding//alpha-amylase activity -- -- -- -- Cluster-4852.0 BF_2 8.00 1.85 468 -- -- -- -- -- 733578671 LN713266.1 42 8.95986e-11 Cucumis melo genomic chromosome, chr_12 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4853.0 BF_2 3.00 0.35 649 645011490 XP_008214275.1 717 3.0e-73 PREDICTED: cytohesin-1 isoform X2 [Nasonia vitripennis] 554585701 XM_005884219.1 106 3.35079e-46 PREDICTED: Myotis brandtii cytohesin 1 (CYTH1), transcript variant X1, mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 583 4.3e-59 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-4854.0 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4861.0 BF_2 8.00 1.18 570 -- -- -- -- -- 694327494 XM_009356338.1 255 4.33304e-129 PREDICTED: Pyrus x bretschneideri probable xyloglucan endotransglucosylase/hydrolase protein 6 (LOC103945749), mRNA -- -- -- -- Q8LF99 894 3.3e-95 Probable xyloglucan endotransglucosylase/hydrolase protein 6 OS=Arabidopsis thaliana GN=XTH6 PE=2 SV=2 PF06955//PF00722 Xyloglucan endo-transglycosylase (XET) C-terminus//Glycosyl hydrolases family 16 GO:0005975//GO:0006073 carbohydrate metabolic process//cellular glucan metabolic process GO:0016762//GO:0004553 xyloglucan:xyloglucosyl transferase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0048046//GO:0005618 apoplast//cell wall -- -- Cluster-4863.0 BF_2 4.00 0.52 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4864.0 BF_2 10.00 0.83 789 768918423 XP_011602474.1 213 1.0e-14 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Takifugu rubripes] 568859676 XM_006483300.1 254 2.19519e-128 PREDICTED: Citrus sinensis EIN3-binding F-box protein 1-like (LOC102621500), mRNA -- -- -- -- Q9SKK0 714 3.4e-74 EIN3-binding F-box protein 1 OS=Arabidopsis thaliana GN=EBF1 PE=1 SV=1 PF13516//PF09029//PF00560 Leucine Rich repeat//5-aminolevulinate synthase presequence//Leucine Rich Repeat GO:0006563//GO:0042967//GO:0006778//GO:0006566//GO:0006783//GO:0006544 L-serine metabolic process//acyl-carrier-protein biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process//heme biosynthetic process//glycine metabolic process GO:0003870//GO:0005515//GO:0030170 5-aminolevulinate synthase activity//protein binding//pyridoxal phosphate binding GO:0005759 mitochondrial matrix KOG4341 F-box protein containing LRR Cluster-4867.0 BF_2 12.00 2.08 528 -- -- -- -- -- 115453180 NM_001056726.1 524 0 Oryza sativa Japonica Group Os03g0369100 (Os03g0369100) mRNA, complete cds >gnl|BL_ORD_ID|3397359 Oryza sativa Japonica Group cDNA clone:002-175-D08, full insert sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4870.0 BF_2 4.46 0.51 656 642914290 XP_008201624.1 325 8.8e-28 PREDICTED: uncharacterized protein LOC103315235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-4873.1 BF_2 3.00 0.43 582 431891271 ELK02148.1 931 4.2e-98 60S ribosomal protein L11 [Pteropus alecto] 315221150 NM_000975.3 582 0 Homo sapiens ribosomal protein L11 (RPL11), transcript variant 1, mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P62914 930 2.2e-99 60S ribosomal protein L11 OS=Rattus norvegicus GN=Rpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-4874.0 BF_2 2.00 0.45 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4879.0 BF_2 46.00 3.58 824 700354676 XP_009921627.1 277 4.1e-22 PREDICTED: glycine-rich RNA-binding protein GRP1A-like, partial [Haliaeetus albicilla] 116637730 CT828687.1 822 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCRA112P01, full insert sequence K13195 CIRBP cold-inducible RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13195 P49310 394 4.5e-37 Glycine-rich RNA-binding protein GRP1A OS=Sinapis alba PE=2 SV=1 PF01213//PF16367//PF00076 Adenylate cyclase associated (CAP) N terminal//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0007010 cytoskeleton organization GO:0003676//GO:0003779 nucleic acid binding//actin binding -- -- -- -- Cluster-4880.0 BF_2 17.00 1.28 843 510949011 YP_007890549.1 330 3.0e-28 NADH dehydrogenase subunit 1 (mitochondrion) [Histiona aroides]>gi|462269218|gb|AGH24043.1| NADH dehydrogenase subunit 1 (mitochondrion) [Histiona aroides] 528540458 AP012528.1 813 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P31839 447 3.3e-43 NADH-ubiquinone oxidoreductase chain 1 OS=Oenothera berteroana GN=ND1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4770 NADH dehydrogenase subunit 1 Cluster-4885.0 BF_2 36.00 1459.06 202 -- -- -- -- -- 530279484 KF184890.1 120 1.5291e-54 Saccharum hybrid cultivar R570 clone BAC 168J15 complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4887.0 BF_2 4.00 7.30 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4896.0 BF_2 10.00 0.87 770 167523118 XP_001745896.1 594 6.6e-59 hypothetical protein [Monosiga brevicollis MX1]>gi|163775697|gb|EDQ89320.1| predicted protein [Monosiga brevicollis MX1] 645241428 XM_008228851.1 361 0 PREDICTED: Prunus mume 40S ribosomal protein S8-like (LOC103326606), mRNA K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 P49199 823 7.6e-87 40S ribosomal protein S8 OS=Oryza sativa subsp. japonica GN=RPS8 PE=2 SV=2 PF06751 Ethanolamine ammonia lyase large subunit (EutB) GO:0006520 cellular amino acid metabolic process GO:0008851 ethanolamine ammonia-lyase activity GO:0030529//GO:0009350 intracellular ribonucleoprotein complex//ethanolamine ammonia-lyase complex KOG3283 40S ribosomal protein S8 Cluster-4898.0 BF_2 7.00 5.79 330 444738097 CCQ43115.1 137 2.8e-06 alternative protein FGFR2 [Homo sapiens] 254553324 NG_012449.1 330 4.8781e-171 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 -- -- -- -- -- -- -- -- PF04815 Sec23/Sec24 helical domain GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport -- -- GO:0030127 COPII vesicle coat -- -- Cluster-4902.0 BF_2 9.00 3.11 407 826487278 XP_012539352.1 274 4.5e-22 PREDICTED: thioredoxin-2-like [Monomorium pharaonis] 568824997 XM_006466814.1 192 3.17792e-94 PREDICTED: Citrus sinensis thioredoxin H-type-like (LOC102624646), mRNA K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q43636 528 6.5e-53 Thioredoxin H-type OS=Ricinus communis PE=3 SV=1 PF00085//PF08534//PF00578 Thioredoxin//Redoxin//AhpC/TSA family GO:0055114//GO:0045454 oxidation-reduction process//cell redox homeostasis GO:0016491//GO:0016209 oxidoreductase activity//antioxidant activity -- -- -- -- Cluster-4907.0 BF_2 7.00 3.21 376 578808637 XP_006714102.1 328 2.2e-28 PREDICTED: platelet-derived growth factor receptor alpha isoform X2 [Homo sapiens] 219521916 NG_009250.1 373 0 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), RefSeqGene (LRG_309) on chromosome 4 K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 P16234 328 9.2e-30 Platelet-derived growth factor receptor alpha OS=Homo sapiens GN=PDGFRA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4909.0 BF_2 1.00 0.61 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4913.0 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4914.0 BF_2 2.00 0.56 436 -- -- -- -- -- 262401427 FJ774896.1 263 1.16384e-133 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4915.0 BF_2 2.00 0.61 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4916.0 BF_2 3.00 0.48 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00344 SecY translocase GO:0015031 protein transport -- -- GO:0016020 membrane -- -- Cluster-4918.0 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4924.0 BF_2 32.78 0.84 1928 300394168 ADK11710.1 695 3.2e-70 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P15144 415 3.9e-39 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-4928.0 BF_2 2.06 0.36 528 170060461 XP_001865813.1 308 6.6e-26 conserved hypothetical protein [Culex quinquefasciatus]>gi|167878927|gb|EDS42310.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-4929.0 BF_2 18.00 3.36 511 -- -- -- -- -- 62526582 AY973620.1 131 3.29923e-60 Manihot esculenta auxin-repressed protein-like protein ARP1 mRNA, complete cds -- -- -- -- Q05349 367 3.8e-34 Auxin-repressed 12.5 kDa protein OS=Fragaria ananassa PE=2 SV=1 PF07365 Alpha conotoxin precursor GO:0009405//GO:0007165//GO:0007268 pathogenesis//signal transduction//synaptic transmission GO:0030550 acetylcholine receptor inhibitor activity GO:0005576 extracellular region -- -- Cluster-4933.0 BF_2 5.00 1.24 456 -- -- -- -- -- 349731553 FQ394674.1 80 6.5474e-32 Vitis vinifera clone SS0AFA1YH08 -- -- -- -- Q40256 172 1.4e-11 Metallothionein-like protein type 3 OS=Musa acuminata PE=3 SV=1 PF01439 Metallothionein -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-4934.0 BF_2 4.00 0.78 502 260836773 XP_002613380.1 216 2.9e-15 hypothetical protein BRAFLDRAFT_118749 [Branchiostoma floridae]>gi|229298765|gb|EEN69389.1| hypothetical protein BRAFLDRAFT_118749 [Branchiostoma floridae] 566245717 XM_002325602.2 254 1.36406e-128 Populus trichocarpa trans-cinnamate 4-monooxygenase family protein (POPTR_0019s15110g) mRNA, complete cds -- -- -- -- Q96423 636 2.4e-65 Trans-cinnamate 4-monooxygenase OS=Glycyrrhiza echinata GN=CYP73A14 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-4936.0 BF_2 3.00 3.51 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4949.0 BF_2 3.00 1.25 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4951.0 BF_2 4.00 0.44 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4952.0 BF_2 3.00 1.53 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4953.0 BF_2 9.00 4.45 369 795170157 XP_011842419.1 336 2.6e-29 PREDICTED: glutathione S-transferase P isoform X4 [Mandrillus leucophaeus] 237820690 NG_012075.1 369 0 Homo sapiens glutathione S-transferase pi 1 (GSTP1), RefSeqGene (LRG_723) on chromosome 11 K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P09211 186 2.6e-13 Glutathione S-transferase P OS=Homo sapiens GN=GSTP1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-4955.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4959.0 BF_2 2.00 0.38 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4960.0 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4961.0 BF_2 1.00 0.57 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4969.0 BF_2 8.00 13.62 292 6006555 CAB56793.1 321 1.1e-27 proto-oncogene [Homo sapiens] 212720875 NG_008996.1 292 5.6608e-150 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2QLF1 321 4.7e-29 Hepatocyte growth factor receptor OS=Pan troglodytes GN=MET PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-4976.0 BF_2 3.00 7.17 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4978.0 BF_2 9.00 0.88 716 91089913 XP_972686.1 740 7.2e-76 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933954|ref|XP_008197580.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933957|ref|XP_008197581.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013662|gb|EFA10110.1| hypothetical protein TcasGA2_TC012289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 278 1.1e-23 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF06699//PF00083//PF07690 GPI biosynthesis protein family Pig-F//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006506 transmembrane transport//GPI anchor biosynthetic process GO:0022857//GO:0022891 transmembrane transporter activity//substrate-specific transmembrane transporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-4979.0 BF_2 3.00 0.72 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4983.0 BF_2 5.00 0.52 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4986.0 BF_2 3.00 0.76 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4988.0 BF_2 2.00 0.68 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4990.0 BF_2 18.00 1.43 813 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9LHE3 294 1.8e-25 Protein ASPARTIC PROTEASE IN GUARD CELL 2 OS=Arabidopsis thaliana GN=ASPG2 PE=2 SV=1 PF00026 Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-4992.0 BF_2 7.00 2.46 405 768442749 XP_011563157.1 319 2.7e-27 PREDICTED: peptidyl-prolyl cis-trans isomerase [Plutella xylostella] 567864835 XM_006425004.1 168 6.93971e-81 Citrus clementina hypothetical protein (CICLE_v10029291mg) mRNA, complete cds K09564 PPIE peptidyl-prolyl isomerase E (cyclophilin E) http://www.genome.jp/dbget-bin/www_bget?ko:K09564 Q8LDP4 371 1.0e-34 Peptidyl-prolyl cis-trans isomerase CYP19-4 OS=Arabidopsis thaliana GN=CYP19-4 PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- -- -- Cluster-4995.0 BF_2 2.00 0.56 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4996.0 BF_2 4.00 0.48 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-4999.0 BF_2 12.00 0.90 847 193875788 ACF24530.1 624 2.4e-62 chlorophyll a/b binding protein CP29 [Gymnochlora stellata] 731401102 XM_002279798.2 380 0 PREDICTED: Vitis vinifera chlorophyll a-b binding protein CP29.2, chloroplastic-like (LOC100266604), mRNA -- -- -- -- Q07473 1157 1.6e-125 Chlorophyll a-b binding protein CP29.1, chloroplastic OS=Arabidopsis thaliana GN=LHCB4.1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5000.0 BF_2 2.00 0.34 534 85544639 2F8A 771 1.4e-79 Chain A, Crystal Structure Of The Selenocysteine To Glycine Mutant Of Human Glutathione Peroxidase 1>gi|85544640|pdb|2F8A|B Chain B, Crystal Structure Of The Selenocysteine To Glycine Mutant Of Human Glutathione Peroxidase 1 41406083 NM_000581.2 534 0 Homo sapiens glutathione peroxidase 1 (GPX1), transcript variant 1, mRNA K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 P07203 771 5.6e-81 Glutathione peroxidase 1 OS=Homo sapiens GN=GPX1 PE=1 SV=4 PF00255 Glutathione peroxidase GO:0006749//GO:0014902//GO:0010332//GO:0006804//GO:0002862//GO:0043534//GO:0043523//GO:0007605//GO:0033599//GO:0001836//GO:0043403//GO:0008631//GO:0009636//GO:0042744//GO:0051450//GO:0006144//GO:0043066//GO:0006641//GO:0060047//GO:0010269//GO:0060055//GO:0048741//GO:0033194//GO:0045444//GO:0045454//GO:0009609//GO:0006979//GO:0051702//GO:0042311//GO:0018158//GO:0006195//GO:0055114//GO:0051897//GO:0001885//GO:0001659//GO:0061136//GO:0009650//GO:0040029//GO:0009410//GO:0043154 glutathione metabolic process//myotube differentiation//response to gamma radiation//obsolete peroxidase reaction//negative regulation of inflammatory response to antigenic stimulus//blood vessel endothelial cell migration//regulation of neuron apoptotic process//sensory perception of sound//regulation of mammary gland epithelial cell proliferation//release of cytochrome c from mitochondria//skeletal muscle tissue regeneration//intrinsic apoptotic signaling pathway in response to oxidative stress//response to toxic substance//hydrogen peroxide catabolic process//myoblast proliferation//purine nucleobase metabolic process//negative regulation of apoptotic process//triglyceride metabolic process//heart contraction//response to selenium ion//angiogenesis involved in wound healing//skeletal muscle fiber development//response to hydroperoxide//fat cell differentiation//cell redox homeostasis//response to symbiotic bacterium//response to oxidative stress//interaction with symbiont//vasodilation//protein oxidation//purine nucleotide catabolic process//oxidation-reduction process//positive regulation of protein kinase B signaling//endothelial cell development//temperature homeostasis//regulation of proteasomal protein catabolic process//UV protection//regulation of gene expression, epigenetic//response to xenobiotic stimulus//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0004602//GO:0017124//GO:0004866 glutathione peroxidase activity//SH3 domain binding//endopeptidase inhibitor activity GO:0005739//GO:0005829 mitochondrion//cytosol KOG1651 Glutathione peroxidase Cluster-5001.0 BF_2 7.00 1.17 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5002.0 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5006.0 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5012.0 BF_2 3.00 0.35 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09334 tRNA synthetases class I (M) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- -- -- Cluster-5013.0 BF_2 3.00 0.74 456 194384514 BAG59417.1 910 8.9e-96 unnamed protein product [Homo sapiens] 767909264 XM_005273124.3 456 0 PREDICTED: Homo sapiens laminin, beta 3 (LAMB3), transcript variant X1, mRNA K06244 LAMB3 laminin, beta 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06244 Q13751 910 3.7e-97 Laminin subunit beta-3 OS=Homo sapiens GN=LAMB3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-5014.0 BF_2 4.00 4.59 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5017.0 BF_2 1.00 1.07 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5021.0 BF_2 7.00 3.88 359 857972311 CEP01348.1 159 8.5e-09 hypothetical protein PBRA_001954 [Plasmodiophora brassicae] 115469557 NM_001064913.1 359 0 Oryza sativa Japonica Group Os06g0681400 (Os06g0681400) mRNA, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q3E7K8 159 3.5e-10 Polyubiquitin 12 OS=Arabidopsis thaliana GN=UBQ12 PE=3 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-5022.0 BF_2 2.00 0.32 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03526 Colicin E1 (microcin) immunity protein GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-5023.0 BF_2 3.00 1.19 391 533185573 XP_005405818.1 504 9.2e-49 PREDICTED: 60S ribosomal protein L36 [Chinchilla lanigera] 78190468 NM_033643.2 391 0 Homo sapiens ribosomal protein L36 (RPL36), transcript variant 1, mRNA K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 Q5RAZ9 480 2.3e-47 60S ribosomal protein L36 OS=Pongo abelii GN=RPL36 PE=3 SV=3 PF01158 Ribosomal protein L36e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-5024.0 BF_2 4.00 0.64 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5029.0 BF_2 1.00 0.68 343 668464962 KFB52200.1 395 3.5e-36 AGAP001653-PA-like protein [Anopheles sinensis] -- -- -- -- -- K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 Q94511 364 5.7e-34 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0009055//GO:0051536 electron carrier activity//iron-sulfur cluster binding -- -- KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-5031.0 BF_2 3.00 0.57 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5032.0 BF_2 6.00 0.37 968 767938662 XP_011532966.1 951 3.3e-100 PREDICTED: calnexin isoform X2 [Homo sapiens] 767938663 XM_011534665.1 968 0 PREDICTED: Homo sapiens calnexin (CANX), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P27824 951 1.4e-101 Calnexin OS=Homo sapiens GN=CANX PE=1 SV=2 PF03348//PF13965//PF00262//PF01080//PF01770//PF03896 Serine incorporator (Serinc)//dsRNA-gated channel SID-1//Calreticulin family//Presenilin//Reduced folate carrier//Translocon-associated protein (TRAP), alpha subunit GO:0033227//GO:0006810//GO:0006457//GO:0015931 dsRNA transport//transport//protein folding//nucleobase-containing compound transport GO:0051033//GO:0051082//GO:0005509//GO:0004190 RNA transmembrane transporter activity//unfolded protein binding//calcium ion binding//aspartic-type endopeptidase activity GO:0016020//GO:0005783//GO:0005789//GO:0016021 membrane//endoplasmic reticulum//endoplasmic reticulum membrane//integral component of membrane KOG0675 Calnexin Cluster-5037.0 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5045.0 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5047.0 BF_2 7.00 10.90 296 126697350 ABO26632.1 349 6.5e-31 glyceraldehyde 3-phosphate dehydrogenase [Haliotis discus discus] 347660100 BT130453.1 296 3.43515e-152 Oryza sativa clone RRlibC00781 mRNA sequence K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q7FAH2 415 5.9e-40 Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic OS=Oryza sativa subsp. japonica GN=GAPC2 PE=1 SV=1 PF00044//PF04349//PF04295//PF02800 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Periplasmic glucan biosynthesis protein, MdoG//D-galactarate dehydratase / Altronate hydrolase, C terminus//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0016051//GO:0055114 carbohydrate biosynthetic process//oxidation-reduction process GO:0016829//GO:0016620 lyase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042597 periplasmic space KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-5049.0 BF_2 5.00 0.44 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5050.0 BF_2 3.00 1.35 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5053.0 BF_2 6.00 0.52 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5055.0 BF_2 2.00 0.74 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5061.0 BF_2 6.00 1.15 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5062.0 BF_2 5.00 2.34 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00257 Dehydrin GO:0009415//GO:0006950 response to water//response to stress -- -- -- -- -- -- Cluster-5063.0 BF_2 4.00 0.48 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5068.0 BF_2 3.00 0.51 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5072.0 BF_2 8.00 4.13 365 524883626 XP_005098440.1 351 4.7e-31 PREDICTED: 60S ribosomal protein L23 isoform X2 [Aplysia californica] 297600293 NM_001055447.2 365 0 Oryza sativa Japonica Group Os03g0139100 (Os03g0139100) mRNA, complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P49690 394 2.0e-37 60S ribosomal protein L23 OS=Arabidopsis thaliana GN=RPL23A PE=2 SV=3 PF00238 Ribosomal protein L14p/L23e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-5073.0 BF_2 2.00 0.48 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5076.0 BF_2 5.00 1.43 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5083.0 BF_2 3.00 0.34 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5085.0 BF_2 5.00 0.99 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5087.0 BF_2 37.00 1.65 1225 225709748 ACO10720.1 549 1.7e-53 Omega-3 fatty acid desaturase, endoplasmic reticulum [Caligus rogercresseyi] 586637178 KC853237.1 1082 0 Juglans regia plastid fatty acid desaturase (FAD) mRNA, complete cds; nuclear gene for plastid product K10257 FAD8, desB omega-3 fatty acid desaturase (delta-15 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K10257 P48620 1530 1.3e-168 Omega-3 fatty acid desaturase, chloroplastic OS=Sesamum indicum GN=FAD7 PE=2 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-5092.0 BF_2 4.00 0.45 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5095.0 BF_2 4.00 0.62 557 -- -- -- -- -- 595798025 XM_007201281.1 156 4.57011e-74 Prunus persica hypothetical protein (PRUPE_ppa011992mg) mRNA, complete cds -- -- -- -- P0C8Z0 209 8.6e-16 Uncharacterized protein OsI_027940 OS=Oryza sativa subsp. indica GN=OsI_027940 PE=1 SV=2 PF08430 Forkhead N-terminal region -- -- GO:0008134//GO:0019904 transcription factor binding//protein domain specific binding GO:0005667 transcription factor complex -- -- Cluster-5097.0 BF_2 16.00 1.55 718 -- -- -- -- -- 568836136 XM_006472041.1 111 6.19218e-49 PREDICTED: Citrus sinensis uncharacterized LOC102616956 (LOC102616956), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5098.1 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5101.0 BF_2 4.00 0.44 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5102.0 BF_2 3.00 0.36 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5103.0 BF_2 25.00 5.18 489 -- -- -- -- -- 528540458 AP012528.1 474 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P10330 162 2.1e-10 NADH-ubiquinone oxidoreductase chain 5 OS=Oenothera berteroana GN=ND5 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-5105.0 BF_2 22.00 4.22 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5106.0 BF_2 1.00 0.87 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03598 CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0015947//GO:0006084 methane metabolic process//acetyl-CoA metabolic process GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity -- -- -- -- Cluster-5108.0 BF_2 6.00 2.62 381 562831352 XP_006145159.1 271 9.3e-22 PREDICTED: serine/threonine-protein kinase B-raf [Tupaia chinensis] 588282806 NG_007873.3 381 0 Homo sapiens B-Raf proto-oncogene, serine/threonine kinase (BRAF), RefSeqGene (LRG_299) on chromosome 7 K04365 BRAF B-Raf proto-oncogene serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04365 P34908 250 1.0e-20 Serine/threonine-protein kinase B-raf OS=Coturnix coturnix japonica GN=BRAF PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0193 Serine/threonine protein kinase RAF Cluster-5109.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5110.0 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5111.0 BF_2 3.00 0.70 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5114.0 BF_2 20.00 2.36 642 557121890 CDI80615.1 516 6.1e-50 translation initiation factor eIF-5A, putative [Eimeria acervulina] 349711535 FQ379154.1 333 2.14571e-172 Vitis vinifera clone SS0AEB11YE20 K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 P24922 795 1.1e-83 Eukaryotic translation initiation factor 5A-2 OS=Nicotiana plumbaginifolia GN=EIF-5A2 PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-5118.0 BF_2 4.00 0.98 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5127.1 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5132.0 BF_2 4.00 1.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5140.0 BF_2 3.00 0.55 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5144.0 BF_2 1.00 4.80 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5145.0 BF_2 1.00 0.59 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5146.0 BF_2 3.00 1.99 345 193875804 ACF24538.1 225 1.8e-16 light harvesting complex protein LHCII-3 [Gymnochlora stellata] 595258492 KJ008954.1 189 1.23344e-92 Pyrus x bretschneideri clone 962 a-b binding protein mRNA, complete cds -- -- -- -- Q01667 530 3.2e-53 Chlorophyll a-b binding protein 6, chloroplastic OS=Arabidopsis thaliana GN=LHCA1 PE=1 SV=1 PF07988 LMSTEN motif GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-5146.1 BF_2 6.00 2.45 388 724888310 XP_010374558.1 161 5.4e-09 PREDICTED: chlorophyll a-b binding protein of LHCII type 1, partial [Rhinopithecus roxellana] 702477056 XM_010033902.1 147 3.12509e-69 PREDICTED: Eucalyptus grandis chlorophyll a-b binding protein 6, chloroplastic (LOC104421798), mRNA -- -- -- -- P12360 563 5.4e-57 Chlorophyll a-b binding protein 6A, chloroplastic OS=Solanum lycopersicum GN=CAB6A PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5149.0 BF_2 1.00 0.69 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5163.0 BF_2 8.00 5.77 339 403372122 EJY85953.1 210 9.8e-15 Peptidyl-prolyl cis-trans isomerase B [Oxytricha trifallax] 156765351 AK288736.1 336 2.32185e-174 Oryza sativa Japonica Group cDNA, clone: J090063K03, full insert sequence K03768 PPIB, ppiB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) http://www.genome.jp/dbget-bin/www_bget?ko:K03768 Q9SP02 229 2.5e-18 Peptidyl-prolyl cis-trans isomerase CYP20-1 OS=Arabidopsis thaliana GN=CYP20-1 PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-5170.0 BF_2 2.00 0.42 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5171.0 BF_2 10.00 1.67 537 795158413 XP_011840045.1 214 5.3e-15 PREDICTED: hamartin isoform X1 [Mandrillus leucophaeus] 254039583 NG_012386.1 537 0 Homo sapiens tuberous sclerosis 1 (TSC1), RefSeqGene (LRG_486) on chromosome 9 K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q92574 214 2.2e-16 Hamartin OS=Homo sapiens GN=TSC1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-5176.0 BF_2 3.00 0.37 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5181.0 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5184.0 BF_2 3.00 2.16 339 546674359 ERL85746.1 170 4.2e-10 hypothetical protein D910_03161 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-5191.0 BF_2 2.00 1.18 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5193.0 BF_2 7.00 1.05 567 -- -- -- -- -- 743914026 XR_839035.1 136 6.1107e-63 PREDICTED: Populus euphratica glucan endo-1,3-beta-glucosidase 14-like (LOC105108349), transcript variant X4, misc_RNA -- -- -- -- Q9ZQG9 479 4.3e-47 Glucan endo-1,3-beta-glucosidase 14 OS=Arabidopsis thaliana GN=At2g27500 PE=1 SV=2 PF00332 Glycosyl hydrolases family 17 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-5199.0 BF_2 2.00 0.32 549 214010183 NP_001135749.1 697 5.4e-71 amyloid-like protein 2 isoform 3 precursor [Homo sapiens]>gi|553204|gb|AAA35601.1| binding protein, partial [Homo sapiens]>gi|208967621|dbj|BAG72456.1| amyloid beta (A4) precursor-like protein 2 [synthetic construct] 214010182 NM_001142277.1 549 0 Homo sapiens amyloid beta (A4) precursor-like protein 2 (APLP2), transcript variant 3, mRNA K08117 APLP2 amyloid beta (A4) precursor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08117 Q06481 697 2.2e-72 Amyloid-like protein 2 OS=Homo sapiens GN=APLP2 PE=1 SV=2 PF06056//PF02177 Putative ATPase subunit of terminase (gpP-like)//Amyloid A4 N-terminal heparin-binding GO:0019069//GO:0007626//GO:0009790//GO:0006878//GO:0007176//GO:0030901//GO:0007617//GO:0030900//GO:0050885//GO:0007186//GO:0030198//GO:0043393//GO:0008203//GO:0001967 viral capsid assembly//locomotory behavior//embryo development//cellular copper ion homeostasis//regulation of epidermal growth factor-activated receptor activity//midbrain development//mating behavior//forebrain development//neuromuscular process controlling balance//G-protein coupled receptor signaling pathway//extracellular matrix organization//regulation of protein binding//cholesterol metabolic process//suckling behavior GO:0004867//GO:0042802//GO:0046914//GO:0003677//GO:0008201//GO:0005524 serine-type endopeptidase inhibitor activity//identical protein binding//transition metal ion binding//DNA binding//heparin binding//ATP binding GO:0005634//GO:0005886//GO:0016021 nucleus//plasma membrane//integral component of membrane -- -- Cluster-5200.0 BF_2 85.00 2.26 1858 291240569 XP_002740183.1 814 4.9e-84 PREDICTED: protein disulfide-isomerase A3-like [Saccoglossus kowalevskii] 193237767 AB373950.1 1834 0 Oryza sativa Japonica Group PDI mRNA for protein disulfide isomerase 1-1, complete cds K08056 PDIA3, GRP58 protein disulfide isomerase family A, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08056 Q53LQ0 2389 4.7e-268 Protein disulfide isomerase-like 1-1 OS=Oryza sativa subsp. japonica GN=PDIL1-1 PE=2 SV=1 PF00085//PF08534//PF01566//PF00578//PF00462//PF06112//PF07912 Thioredoxin//Redoxin//Natural resistance-associated macrophage protein//AhpC/TSA family//Glutaredoxin//Gammaherpesvirus capsid protein//ERp29, N-terminal domain GO:0006118//GO:0045454//GO:0055114//GO:0006810//GO:0009306 obsolete electron transport//cell redox homeostasis//oxidation-reduction process//transport//protein secretion GO:0015035//GO:0016209//GO:0009055//GO:0016491//GO:0005215 protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity//oxidoreductase activity//transporter activity GO:0016020//GO:0019028//GO:0005788 membrane//viral capsid//endoplasmic reticulum lumen KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-5202.0 BF_2 2.00 0.56 436 675386992 KFM79889.1 404 4.0e-37 Dual specificity protein phosphatase 16, partial [Stegodyphus mimosarum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9BY84 308 2.2e-27 Dual specificity protein phosphatase 16 OS=Homo sapiens GN=DUSP16 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5203.0 BF_2 3.00 1.42 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5212.0 BF_2 4.00 1.24 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5212.1 BF_2 1.00 2.52 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5218.0 BF_2 13.00 1.94 568 -- -- -- -- -- 351734543 NM_001249217.1 135 2.20192e-62 Glycine max uncharacterized LOC100305746 (LOC100305746), mRNA >gnl|BL_ORD_ID|7208903 Soybean clone JCVI-FLGm-2M11 unknown mRNA -- -- -- -- Q949Q5 539 4.8e-54 Photosystem I subunit O OS=Arabidopsis thaliana GN=PSAO PE=1 SV=1 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-5225.0 BF_2 3.00 0.86 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5229.0 BF_2 2.00 0.97 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5230.0 BF_2 9.00 0.35 1369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5231.0 BF_2 4.00 0.80 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5236.0 BF_2 26.00 4.37 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9SRE6 129 1.6e-06 Calcium-binding protein CML38 OS=Arabidopsis thaliana GN=CML38 PE=2 SV=1 PF13202//PF13499//PF00036//PF10591//PF13833//PF13405 EF hand//EF-hand domain pair//EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-5238.0 BF_2 3.00 0.43 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5239.0 BF_2 1.00 0.77 335 290462417 ADD24256.1 241 2.5e-18 60S ribosomal protein L39 [Lepeophtheirus salmonis] 819320163 KP245805.1 182 9.29497e-89 Betula luminifera RPL39 (RPL39) mRNA, complete cds K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 Q5SMI4 271 3.4e-23 60S ribosomal protein L39-3 OS=Oryza sativa subsp. japonica GN=RPL39C PE=3 SV=1 PF00832 Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0002 60s ribosomal protein L39 Cluster-5247.0 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5248.0 BF_2 14.00 2.20 553 336455288 AEI59124.1 151 1.1e-07 cysteine proteases inhibitor [Haliotis discus hannai] 4150973 AJ224331.1 175 1.24323e-84 Castanea sativa mRNA for cystatin, complete CDS -- -- -- -- Q06445 373 8.2e-35 Cysteine proteinase inhibitor OS=Vigna unguiculata PE=3 SV=1 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-5249.0 BF_2 7.00 0.97 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5253.0 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5254.0 BF_2 3.00 0.71 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5255.0 BF_2 2.00 0.36 520 -- -- -- -- -- 258644474 AP009082.1 484 0 Oryza sativa Indica Group DNA, chromosome 8, BAC clone: K0063H06 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5257.0 BF_2 4.00 0.61 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5258.0 BF_2 6.00 0.51 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5259.0 BF_2 6.00 1.37 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5260.0 BF_2 3.00 0.42 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5262.0 BF_2 4.00 0.34 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5264.0 BF_2 4.00 65.97 221 119580095 EAW59691.1 250 1.5e-19 hCG1777113, isoform CRA_a [Homo sapiens] 9801319 AL157837.10 175 4.5302e-85 Human DNA sequence from clone RP11-467I21 on chromosome 1q31.1-31.3, complete sequence -- -- -- -- O00370 156 4.8e-10 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5266.0 BF_2 2.00 0.47 466 861625527 KMQ88569.1 165 2.2e-09 retrovirus-like pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5273.0 BF_2 5.00 0.43 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5274.0 BF_2 3.00 1.94 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5278.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5283.0 BF_2 13.13 0.45 1499 570341962 AHE77378.1 332 3.1e-28 small heat shock protein, partial [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 227 1.9e-17 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-5286.0 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5289.0 BF_2 17.00 3.49 491 578359020 AHI15753.1 802 3.2e-83 glycoside hydrolase family 45 [Apriona japonica] 578359019 KJ186855.1 484 0 Apriona japonica glycoside hydrolase family 45 (gh45-2) mRNA, complete cds -- -- -- -- O97401 428 3.1e-41 Endoglucanase OS=Phaedon cochleariae PE=2 SV=1 PF15677//PF02015 Cell cycle exit and neuronal differentiation protein 1//Glycosyl hydrolase family 45 GO:0005975//GO:0021549//GO:0005982//GO:0030182//GO:0005985 carbohydrate metabolic process//cerebellum development//starch metabolic process//neuron differentiation//sucrose metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-5291.0 BF_2 3.00 0.65 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5294.0 BF_2 5.00 1.15 469 157136459 XP_001656837.1 212 8.0e-15 AAEL003459-PA [Aedes aegypti]>gi|108881006|gb|EAT45231.1| AAEL003459-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q95RI5 195 3.1e-14 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF08496//PF05132//PF03839//PF04194//PF02487//PF02535//PF06459//PF04081 Peptidase family S49 N-terminal//RNA polymerase III RPC4//Translocation protein Sec62//Programmed cell death protein 2, C-terminal putative domain//CLN3 protein//ZIP Zinc transporter//Ryanodine Receptor TM 4-6//DNA polymerase delta, subunit 4 GO:0055085//GO:0006816//GO:0015031//GO:0006874//GO:0006260//GO:0006144//GO:0006383//GO:0006351//GO:0030001//GO:0006206 transmembrane transport//calcium ion transport//protein transport//cellular calcium ion homeostasis//DNA replication//purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//metal ion transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0004252//GO:0008565//GO:0005219//GO:0003677//GO:0046873 DNA-directed RNA polymerase activity//serine-type endopeptidase activity//protein transporter activity//ryanodine-sensitive calcium-release channel activity//DNA binding//metal ion transmembrane transporter activity GO:0016021//GO:0005730//GO:0005737//GO:0005666//GO:0005622//GO:0005886//GO:0005634//GO:0016020 integral component of membrane//nucleolus//cytoplasm//DNA-directed RNA polymerase III complex//intracellular//plasma membrane//nucleus//membrane -- -- Cluster-5298.0 BF_2 2.00 0.36 520 60593111 AAX28841.1 229 9.4e-17 RNA-dependent DNA polymerase [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- P10394 229 3.9e-18 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-5302.0 BF_2 3.00 0.53 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5308.0 BF_2 2.00 2.39 309 -- -- -- -- -- 820703214 LN847507.1 309 2.13914e-159 TPA: Homo sapiens SCARNA7 gene for small nucleolar RNA SCARNA7 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5309.0 BF_2 12.00 0.77 938 826351702 XP_012520260.1 504 2.2e-48 PREDICTED: smoothened homolog [Propithecus coquereli] 300360510 NG_023340.1 938 0 Homo sapiens smoothened, frizzled class receptor (SMO), RefSeqGene on chromosome 7 K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 P56726 460 1.1e-44 Smoothened homolog OS=Mus musculus GN=Smo PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-5314.0 BF_2 11.00 4.62 385 694907842 XP_009446161.1 543 2.7e-53 PREDICTED: platelet-derived growth factor receptor alpha [Pan troglodytes] 219521916 NG_009250.1 385 0 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), RefSeqGene (LRG_309) on chromosome 4 K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 P16234 542 1.4e-54 Platelet-derived growth factor receptor alpha OS=Homo sapiens GN=PDGFRA PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-5315.0 BF_2 3.00 1.41 374 642921531 XP_008192413.1 156 2.0e-08 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-5317.0 BF_2 6.00 2.52 385 -- -- -- -- -- 316939059 HQ229954.1 197 4.96969e-97 Hevea brasiliensis cinnamoyl-CoA reductase (CCR) mRNA, complete cds -- -- -- -- Q9S9N9 455 1.8e-44 Cinnamoyl-CoA reductase 1 OS=Arabidopsis thaliana GN=CCR1 PE=1 SV=1 PF01370//PF01073 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-5318.0 BF_2 11.66 0.67 1018 642918551 XP_008198974.1 884 2.1e-92 PREDICTED: fork head domain-containing protein FD2-like [Tribolium castaneum] 701432873 XM_010006257.1 59 7.18494e-20 PREDICTED: Chaetura pelagica forkhead box protein L1-like (LOC104396420), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 Q02360 473 3.9e-46 Fork head domain-containing protein FD2 OS=Drosophila melanogaster GN=fd64A PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-5321.0 BF_2 5.00 4.34 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5323.0 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5325.0 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5326.0 BF_2 3.00 0.32 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5338.0 BF_2 6.00 2.57 383 194318492 ACF47634.1 341 7.1e-30 soluble FGFR2 variant 1 [Homo sapiens] 254553324 NG_012449.1 383 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21803 242 8.8e-20 Fibroblast growth factor receptor 2 OS=Mus musculus GN=Fgfr2 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-5339.0 BF_2 2.00 0.36 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5340.0 BF_2 4.00 0.33 800 4503107 NP_000090.1 602 8.1e-60 cystatin-C precursor [Homo sapiens]>gi|568599832|ref|NP_001275543.1| cystatin-C precursor [Homo sapiens]>gi|694978356|ref|XP_009435204.1| PREDICTED: cystatin-C [Pan troglodytes]>gi|118183|sp|P01034.1|CYTC_HUMAN RecName: Full=Cystatin-C; AltName: Full=Cystatin-3; AltName: Full=Gamma-trace; AltName: Full=Neuroendocrine basic polypeptide; AltName: Full=Post-gamma-globulin; Flags: Precursor>gi|296643|emb|CAA36497.1| cystatin C [Homo sapiens]>gi|755738|emb|CAA29096.1| cystatin C [Homo sapiens]>gi|4490944|emb|CAA43856.2| cystatin C [Homo sapiens]>gi|15341822|gb|AAH13083.1| Cystatin C [Homo sapiens]>gi|30582517|gb|AAP35485.1| cystatin C (amyloid angiopathy and cerebral hemorrhage) [Homo sapiens]>gi|49456929|emb|CAG46785.1| CST3 [Homo sapiens]>gi|49456989|emb|CAG46815.1| CST3 [Homo sapiens]>gi|60820979|gb|AAX36556.1| cystatin C [synthetic construct]>gi|61360748|gb|AAX41918.1| cystatin C [synthetic construct]>gi|61360752|gb|AAX41919.1| cystatin C [synthetic construct]>gi|82571743|gb|AAI10306.1| Cystatin C [Homo sapiens]>gi|119630542|gb|EAX10137.1| cystatin C (amyloid angiopathy and cerebral hemorrhage), isoform CRA_a [Homo sapiens]>gi|119630543|gb|EAX10138.1| cystatin C (amyloid angiopathy and cerebral hemorrhage), isoform CRA_a [Homo sapiens]>gi|123981072|gb|ABM82365.1| cystatin C (amyloid angiopathy and cerebral hemorrhage) [synthetic construct]>gi|157928178|gb|ABW03385.1| cystatin C (amyloid angiopathy and cerebral hemorrhage) [synthetic construct]>gi|189053333|dbj|BAG35146.1| unnamed protein product [Homo sapiens]>gi|307684684|dbj|BAJ20382.1| cystatin C [synthetic construct] 568599816 NM_000099.3 800 0 Homo sapiens cystatin C (CST3), transcript variant 1, mRNA K13899 CST3 cystatin-C http://www.genome.jp/dbget-bin/www_bget?ko:K13899 P01034 602 3.3e-61 Cystatin-C OS=Homo sapiens GN=CST3 PE=1 SV=1 PF00031 Cystatin domain GO:0010703//GO:0010035//GO:0060548//GO:0010951//GO:0006952//GO:0007566//GO:0048678//GO:0008284//GO:0006915//GO:0001775//GO:0070301//GO:0009636//GO:0009743//GO:0045740//GO:0031667//GO:0032355//GO:0010711//GO:0043206//GO:0007431//GO:0001654//GO:0060009//GO:0043067//GO:0042747//GO:0010716//GO:0001666//GO:0060311//GO:0042493//GO:0060313//GO:0007420 negative regulation of histolysis//response to inorganic substance//negative regulation of cell death//negative regulation of endopeptidase activity//defense response//embryo implantation//response to axon injury//positive regulation of cell proliferation//apoptotic process//cell activation//cellular response to hydrogen peroxide//response to toxic substance//response to carbohydrate//positive regulation of DNA replication//response to nutrient levels//response to estradiol//negative regulation of collagen catabolic process//extracellular fibril organization//salivary gland development//eye development//Sertoli cell development//regulation of programmed cell death//circadian sleep/wake cycle, REM sleep//negative regulation of extracellular matrix disassembly//response to hypoxia//negative regulation of elastin catabolic process//response to drug//negative regulation of blood vessel remodeling//brain development GO:0002020//GO:0004869//GO:0001540 protease binding//cysteine-type endopeptidase inhibitor activity//beta-amyloid binding GO:0043025//GO:0031965//GO:0005764//GO:0048471//GO:0005604//GO:0005783//GO:0031982//GO:0005771//GO:0033267//GO:0005615//GO:0043292 neuronal cell body//nuclear membrane//lysosome//perinuclear region of cytoplasm//basement membrane//endoplasmic reticulum//vesicle//multivesicular body//axon part//extracellular space//contractile fiber -- -- Cluster-5343.0 BF_2 9.00 0.47 1084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5350.0 BF_2 2.00 0.39 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5352.0 BF_2 9.00 2.13 464 167521652 XP_001745164.1 254 1.1e-19 hypothetical protein [Monosiga brevicollis MX1]>gi|163776122|gb|EDQ89742.1| predicted protein [Monosiga brevicollis MX1] 388503375 BT139959.1 152 6.30415e-72 Lotus japonicus clone JCVI-FLLj-7K17 unknown mRNA -- -- -- -- P48534 369 2.0e-34 L-ascorbate peroxidase, cytosolic OS=Pisum sativum GN=APX1 PE=1 SV=2 PF00141 Peroxidase GO:0006804//GO:0055114//GO:0006979 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- -- -- Cluster-5353.0 BF_2 3.00 0.38 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5356.0 BF_2 3.00 0.40 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5360.0 BF_2 17.00 484.25 209 -- -- -- -- -- 46518327 AP004692.2 196 8.9907e-97 Oryza sativa Japonica Group genomic DNA, chromosome 8, PAC clone:P0455A11 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5363.0 BF_2 5.00 0.60 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5368.0 BF_2 1.00 0.98 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0015031//GO:0006886//GO:0008277 protein transport//intracellular protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-5369.0 BF_2 4.00 0.66 539 443695099 ELT96079.1 380 3.0e-34 hypothetical protein CAPTEDRAFT_120620, partial [Capitella teleta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03702 Uncharacterised protein family (UPF0075) GO:0009254//GO:0006040 peptidoglycan turnover//amino sugar metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-5370.0 BF_2 2.00 0.31 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00572 Ribosomal protein L13 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-5373.0 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5374.0 BF_2 10.00 2.68 443 -- -- -- -- -- 347446963 BT129151.1 425 0 Oryza sativa clone RRlibA00366 mRNA sequence -- -- -- -- P37833 239 2.3e-19 Aspartate aminotransferase, cytoplasmic OS=Oryza sativa subsp. japonica GN=Os01g0760600 PE=2 SV=1 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-5376.0 BF_2 18.00 1.53 778 470503734 XP_004347766.1 185 1.8e-11 carrier superfamily protein [Acanthamoeba castellanii str. Neff]>gi|440800905|gb|ELR21934.1| carrier superfamily protein [Acanthamoeba castellanii str. Neff] 115444900 NM_001052765.1 755 0 Oryza sativa Japonica Group Os02g0202400 (Os02g0202400) mRNA, complete cds K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 P29518 446 4.0e-43 Adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial OS=Zea mays GN=BT1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0036 Predicted mitochondrial carrier protein Cluster-5377.0 BF_2 2.00 5.61 272 759100021 XP_011375277.1 333 4.3e-29 PREDICTED: LOW QUALITY PROTEIN: 40S ribosomal protein S29 [Pteropus vampyrus] 459642366 NM_001032.4 272 6.85353e-139 Homo sapiens ribosomal protein S29 (RPS29), transcript variant 1, mRNA K02980 RP-S29e, RPS29 small subunit ribosomal protein S29e http://www.genome.jp/dbget-bin/www_bget?ko:K02980 P62273 319 7.4e-29 40S ribosomal protein S29 OS=Homo sapiens GN=RPS29 PE=1 SV=2 PF00253 Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3506 40S ribosomal protein S29 Cluster-5382.0 BF_2 18.00 1.10 969 873228375 CEM15978.1 943 2.8e-99 unnamed protein product [Vitrella brassicaformis CCMP3155] 38636525 AJ577266.2 650 0 Quercus robur mRNA for formate dehydrogenase (ORF1) -- -- -- -- Q07511 1544 2.4e-170 Formate dehydrogenase, mitochondrial OS=Solanum tuberosum GN=FDH1 PE=1 SV=2 PF03447//PF03446//PF02826//PF00389 Homoserine dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0055114//GO:0019521//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//metabolic process//pentose-phosphate shunt GO:0004616//GO:0051287//GO:0016616//GO:0016491//GO:0050661 phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//NADP binding -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-5387.0 BF_2 4.00 1.60 390 871269897 XP_012944825.1 252 1.5e-19 PREDICTED: 40S ribosomal protein S25 [Aplysia californica] 658018448 XM_008346362.1 118 4.15253e-53 PREDICTED: Malus x domestica 40S ribosomal protein S25-2 (LOC103407425), mRNA K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q9SIK2 337 8.7e-31 40S ribosomal protein S25-2 OS=Arabidopsis thaliana GN=RPS25B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1767 40S ribosomal protein S25 Cluster-5388.0 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5392.0 BF_2 3.00 0.67 474 675368973 KFM61875.1 358 9.4e-32 Retrovirus-related Pol polyprotein from transposon 17.6, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5394.0 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5400.0 BF_2 1.00 0.55 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5407.0 BF_2 3.00 0.45 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5408.0 BF_2 5.00 0.67 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5415.0 BF_2 1.00 1.26 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5421.0 BF_2 5.00 2.56 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5424.0 BF_2 5.00 0.32 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5425.0 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5430.0 BF_2 2.00 0.49 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5431.0 BF_2 5.00 1.31 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5432.0 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5433.0 BF_2 2.00 0.99 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5436.0 BF_2 80.00 12.63 552 -- -- -- -- -- 339269304 HQ730758.1 51 1.05909e-15 Malus x domestica type 3 metallothionein (MT3) mRNA, complete cds -- -- -- -- P43389 231 2.4e-18 Metallothionein-like protein type 3 OS=Actinidia deliciosa GN=pKIWI503 PE=2 SV=1 PF01439 Metallothionein -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-5439.0 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5441.0 BF_2 10.00 0.55 1047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5443.0 BF_2 3.00 0.55 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5445.0 BF_2 17.00 4.01 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5447.0 BF_2 26.00 1.67 940 470265930 XP_004361629.1 139 4.7e-06 putative aspartyl protease [Dictyostelium fasciculatum]>gi|328875414|gb|EGG23778.1| putative aspartyl protease [Dictyostelium fasciculatum] -- -- -- -- -- -- -- -- -- Q9LS40 732 3.3e-76 Protein ASPARTIC PROTEASE IN GUARD CELL 1 OS=Arabidopsis thaliana GN=ASPG1 PE=1 SV=1 PF00026 Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-5450.0 BF_2 2.00 1.88 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5451.0 BF_2 2.00 1.11 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5461.0 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5462.0 BF_2 4.00 0.89 476 3493214 AAC33318.1 494 1.6e-47 pol polyprotein [Drosophila virilis] -- -- -- -- -- -- -- -- -- P04323 491 1.5e-48 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-5463.0 BF_2 4.00 0.47 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5470.0 BF_2 2.00 0.38 510 780099929 XP_011675124.1 155 3.5e-08 PREDICTED: ankyrin-1-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q5ZIJ9 138 1.3e-07 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF14722//PF13606//PF00023//PF09284 Ki-ras-induced actin-interacting protein-IP3R-interacting domain//Ankyrin repeat//Ankyrin repeat//Rhamnogalacturonan lyase B, N-terminal GO:0005975//GO:0007165 carbohydrate metabolic process//signal transduction GO:0005515//GO:0016837//GO:0005102//GO:0030246 protein binding//carbon-oxygen lyase activity, acting on polysaccharides//receptor binding//carbohydrate binding -- -- -- -- Cluster-5472.0 BF_2 6.00 1.51 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5482.0 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5484.0 BF_2 6.00 0.34 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5493.0 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5500.0 BF_2 5.00 0.77 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5501.0 BF_2 10.00 16.65 293 611970079 XP_007480143.1 182 1.5e-11 PREDICTED: leukocyte tyrosine kinase receptor isoform X2 [Monodelphis domestica] 221554531 NG_009445.1 293 1.57999e-150 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 179 1.4e-12 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1095 Protein tyrosine kinase Cluster-5504.0 BF_2 11.00 1.08 712 330806620 XP_003291265.1 811 4.2e-84 inositol-3-phosphate synthase [Dictyostelium purpureum]>gi|325078585|gb|EGC32229.1| inositol-3-phosphate synthase [Dictyostelium purpureum] 703077304 XM_010092256.1 387 0 Morus notabilis Inositol-3-phosphate synthase partial mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q9SSV4 999 2.7e-107 Inositol-3-phosphate synthase OS=Nicotiana paniculata GN=INPS1 PE=2 SV=1 PF07994 Myo-inositol-1-phosphate synthase GO:0019872//GO:0008654//GO:0006021 streptomycin biosynthetic process//phospholipid biosynthetic process//inositol biosynthetic process GO:0000166//GO:0004512 nucleotide binding//inositol-3-phosphate synthase activity -- -- KOG0693 Myo-inositol-1-phosphate synthase Cluster-5508.0 BF_2 2.00 1.33 345 795014455 XP_011883890.1 148 1.5e-07 PREDICTED: uncharacterized protein LOC105571033 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5509.0 BF_2 40.00 1.35 1527 761380068 YP_009121379.1 521 3.8e-50 NADH dehydrogenase subunit 6 (mitochondrion) [Thecamonas trahens]>gi|751130555|gb|AJF36633.1| NADH dehydrogenase subunit 6 (mitochondrion) [Thecamonas trahens] 528540458 AP012528.1 1380 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- Q02500 991 5.0e-106 NADH-ubiquinone oxidoreductase chain 6 OS=Triticum aestivum GN=ND6 PE=3 SV=1 PF04923//PF00499//PF01578 Ninjurin//NADH-ubiquinone/plastoquinone oxidoreductase chain 6//Cytochrome C assembly protein GO:0006120//GO:0042246//GO:0006814//GO:0017004//GO:0007155//GO:0006744//GO:0055114//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//tissue regeneration//sodium ion transport//cytochrome complex assembly//cell adhesion//ubiquinone biosynthetic process//oxidation-reduction process//proton transport GO:0020037//GO:0008137 heme binding//NADH dehydrogenase (ubiquinone) activity GO:0016021 integral component of membrane -- -- Cluster-5510.0 BF_2 2.00 1.79 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5515.0 BF_2 3.00 0.91 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5517.0 BF_2 10.00 0.96 722 224044599 XP_002193705.1 558 9.3e-55 PREDICTED: 3-ketoacyl-CoA thiolase, peroxisomal [Taeniopygia guttata] 658027226 XM_008350825.1 364 0 PREDICTED: Malus x domestica 3-ketoacyl-CoA thiolase 2, peroxisomal-like (LOC103412230), mRNA K07513 ACAA1 acetyl-CoA acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07513 Q56WD9 780 6.9e-82 3-ketoacyl-CoA thiolase 2, peroxisomal OS=Arabidopsis thaliana GN=PED1 PE=1 SV=2 PF00108//PF02803//PF08541 Thiolase, N-terminal domain//Thiolase, C-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal GO:0008152//GO:0008610 metabolic process//lipid biosynthetic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1389 3-oxoacyl CoA thiolase Cluster-5523.0 BF_2 11.00 2.51 470 -- -- -- -- -- 584458492 NG_033929.1 470 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5525.0 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5526.0 BF_2 2.00 0.31 554 795193199 XP_011846882.1 979 1.1e-103 PREDICTED: calponin-3 isoform X2 [Mandrillus leucophaeus] 649099275 KJ890945.1 554 0 Synthetic construct Homo sapiens clone ccsbBroadEn_00339 CNN3 gene, encodes complete protein -- -- -- -- Q15417 979 4.4e-105 Calponin-3 OS=Homo sapiens GN=CNN3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5528.0 BF_2 1.00 0.33 412 106017 755 7.6e-78 fibulin 1 precursor, splice form B - human>gi|31417|emb|CAA37771.1| fibulin-1 B [Homo sapiens]>gi|227478|prf||1704259A fibulin B 318037493 NM_001996.3 412 0 Homo sapiens fibulin 1 (FBLN1), transcript variant C, mRNA K17307 FBLN1_2 fibulin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17307 P23142 751 9.1e-79 Fibulin-1 OS=Homo sapiens GN=FBLN1 PE=1 SV=4 PF01821 Anaphylotoxin-like domain GO:0007566//GO:0030198//GO:0019048 embryo implantation//extracellular matrix organization//modulation by virus of host morphology or physiology GO:0005509//GO:0016504//GO:0005201 calcium ion binding//peptidase activator activity//extracellular matrix structural constituent GO:0005576//GO:0005578//GO:0005615//GO:0005604 extracellular region//proteinaceous extracellular matrix//extracellular space//basement membrane -- -- Cluster-5529.0 BF_2 3.00 0.45 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5530.0 BF_2 2.00 0.56 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5531.0 BF_2 2.00 0.36 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5534.0 BF_2 19.00 3.53 512 569370825 ETO11380.1 293 3.5e-24 malate dehydrogenase [Reticulomyxa filosa] 119395239 EF122494.1 511 0 Oryza sativa (japonica cultivar-group) clone KCS327A11 malate dehydrogenase mRNA, complete cds K00025 MDH1 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00025 Q7XDC8 438 2.2e-42 Malate dehydrogenase, cytoplasmic OS=Oryza sativa subsp. japonica GN=Os10g0478200 PE=1 SV=3 PF02866 lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1496 Malate dehydrogenase Cluster-5535.0 BF_2 4.00 1.76 380 -- -- -- -- -- 731400391 XM_002276298.3 80 5.37104e-32 PREDICTED: Vitis vinifera probable calcium-binding protein CML35 (LOC100264151), mRNA -- -- -- -- Q9SS31 170 2.0e-11 Probable calcium-binding protein CML36 OS=Arabidopsis thaliana GN=CML36 PE=2 SV=1 PF13202//PF13499//PF13405//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-5536.0 BF_2 2.00 0.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5537.0 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5547.0 BF_2 8.00 1.54 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- -- -- Cluster-5549.0 BF_2 12.00 0.38 1612 91088333 XP_970609.1 1068 1.5e-113 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V7S5 600 1.1e-60 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00487 Major Facilitator Superfamily//Fatty acid desaturase GO:0006629//GO:0055085 lipid metabolic process//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-5552.0 BF_2 47.00 5.24 662 -- -- -- -- -- 15149874 AJ277599.2 175 1.50433e-84 Quercus suber mRNA for metallothionein-like protein (mt gene) -- -- -- -- P43390 219 7.1e-17 Metallothionein-like protein type 2 OS=Actinidia deliciosa GN=pKIWI504 PE=2 SV=1 PF01439 Metallothionein -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-5564.0 BF_2 2.00 0.38 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5566.0 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5568.0 BF_2 3.00 0.51 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5569.0 BF_2 4.00 1.16 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5578.0 BF_2 17.00 1.60 731 156542773 XP_001602816.1 472 8.8e-45 PREDICTED: 40S ribosomal protein S19 [Nasonia vitripennis] 116636883 CT828071.1 671 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCSN067P05, full insert sequence K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P40978 765 3.8e-80 40S ribosomal protein S19 OS=Oryza sativa subsp. japonica GN=RPS19A PE=3 SV=1 PF01090 Ribosomal protein S19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-5579.0 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5580.0 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5591.0 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13292 1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694 terpenoid biosynthetic process//steroid biosynthetic process GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity -- -- -- -- Cluster-5595.0 BF_2 1.00 0.38 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5597.0 BF_2 3.00 0.39 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5598.0 BF_2 13.00 4.07 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5604.0 BF_2 6.00 0.40 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5605.0 BF_2 4.00 0.36 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-5606.0 BF_2 8.00 1.23 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03832 WSK motif GO:0007165//GO:0006605 signal transduction//protein targeting -- -- -- -- -- -- Cluster-5607.0 BF_2 8.00 3.36 385 795549696 XP_011905989.1 222 4.5e-16 PREDICTED: proto-oncogene tyrosine-protein kinase ROS [Cercocebus atys] 584458492 NG_033929.1 385 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 222 1.9e-17 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-5609.0 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5610.0 BF_2 2.00 0.45 473 507683722 XP_004711262.1 579 2.2e-57 PREDICTED: 60S ribosomal protein L36a, partial [Echinops telfairi] 675707725 XM_003810412.2 355 0 PREDICTED: Pan paniscus ribosomal protein L36a (RPL36A), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 P83883 567 2.3e-57 60S ribosomal protein L36a OS=Rattus norvegicus GN=Rpl36a PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3464 60S ribosomal protein L44 Cluster-5613.0 BF_2 1.00 0.38 396 15214544 AAH12396.1 347 1.5e-30 C17orf45 protein, partial [Homo sapiens] 224548962 NR_027166.1 396 0 Homo sapiens LRRC75A antisense RNA 1 (LRRC75A-AS1), transcript variant 10, long non-coding RNA -- -- -- -- Q8N1F1 173 9.1e-12 Putative uncharacterized protein LRRC75A-AS1, mitochondrial OS=Homo sapiens GN=LRRC75A-AS1 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5623.0 BF_2 3.00 0.35 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5629.0 BF_2 3.00 0.41 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5638.1 BF_2 4.00 0.47 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5642.0 BF_2 5.00 0.54 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5648.0 BF_2 1.00 0.55 359 874493613 XP_012961712.1 566 5.4e-56 PREDICTED: adiponectin receptor protein 1 [Anas platyrhynchos] 686700490 XM_002809586.3 359 0 PREDICTED: Pongo abelii adiponectin receptor 1 (ADIPOR1), mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q91VH1 566 2.2e-57 Adiponectin receptor protein 1 OS=Mus musculus GN=Adipor1 PE=1 SV=1 PF03006//PF00892 Haemolysin-III related//EamA-like transporter family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-5652.0 BF_2 2.00 0.99 369 768344560 XP_011600247.1 305 1.0e-25 PREDICTED: actin-related protein 2 [Aquila chrysaetos canadensis] 694894488 XM_009442569.1 366 0 PREDICTED: Pan troglodytes ARP2 actin-related protein 2 homolog (yeast) (ACTR2), transcript variant X2, mRNA K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P53488 305 4.2e-27 Actin-related protein 2 OS=Gallus gallus GN=ACTR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-5654.0 BF_2 2.00 0.39 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5656.0 BF_2 72.00 7.77 675 -- -- -- -- -- 46806602 AP005874.3 675 0 Oryza sativa Japonica Group genomic DNA, chromosome 2, BAC clone:OSJNBa0016G10 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5662.0 BF_2 9.00 1.91 484 528770013 EPY89672.1 277 2.4e-22 discoidin domain-containing receptor 2 isoform 2 [Camelus ferus] 282721095 NG_016290.1 481 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q62371 276 1.3e-23 Discoidin domain-containing receptor 2 OS=Mus musculus GN=Ddr2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-5665.0 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5670.0 BF_2 2.00 0.37 516 642912272 XP_008200632.1 236 1.4e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5681.0 BF_2 2.00 0.64 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5683.0 BF_2 5.38 0.63 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5685.0 BF_2 3.00 0.58 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5686.0 BF_2 3.00 0.46 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5688.0 BF_2 1.00 0.40 389 478254423 ENN74675.1 408 1.2e-37 hypothetical protein YQE_08792, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03233//PF08777//PF04513//PF05531//PF15734 Aphid transmission protein//RNA binding motif//Baculovirus polyhedron envelope protein, PEP, C terminus//Nucleopolyhedrovirus P10 protein//Migration and invasion-inhibitory GO:0030336//GO:0019089//GO:0010972 negative regulation of cell migration//transmission of virus//negative regulation of G2/M transition of mitotic cell cycle GO:0005198//GO:0003723 structural molecule activity//RNA binding GO:0019031//GO:0019028 viral envelope//viral capsid -- -- Cluster-5698.0 BF_2 3.00 0.32 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5699.0 BF_2 14.00 1.49 681 -- -- -- -- -- 385718871 JF969237.1 675 0 Oryza sativa clone KCB711H10 Sucrose synthase 2 mRNA, complete cds -- -- -- -- P30298 1191 1.4e-129 Sucrose synthase 2 OS=Oryza sativa subsp. japonica GN=SUS2 PE=1 SV=2 PF06017//PF00862 Unconventional myosin tail, actin- and lipid-binding//Sucrose synthase GO:0005985//GO:0005982 sucrose metabolic process//starch metabolic process GO:0016157//GO:0003774 sucrose synthase activity//motor activity GO:0016459 myosin complex -- -- Cluster-5701.0 BF_2 29.00 2.70 736 470323642 XP_004349545.1 400 2.0e-36 glutathione transferase [Capsaspora owczarzaki ATCC 30864]>gi|765551074|gb|KJE91695.1| glutathione transferase [Capsaspora owczarzaki ATCC 30864] 819320786 KP245819.1 280 7.18691e-143 Betula luminifera glutathione S-transferase-like protein (GST) mRNA, partial cds -- -- -- -- P46423 715 2.4e-74 Glutathione S-transferase OS=Hyoscyamus muticus PE=1 SV=1 PF02798//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-5702.0 BF_2 4.00 0.42 687 823470890 XP_012424195.1 1033 7.3e-110 PREDICTED: 14-3-3 protein epsilon [Taeniopygia guttata] 767992516 XM_005256784.2 687 0 PREDICTED: Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon (YWHAE), transcript variant X1, mRNA >gnl|BL_ORD_ID|28070714 PREDICTED: Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon (YWHAE), transcript variant X1, mRNA K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 P62260 1033 3.0e-111 14-3-3 protein epsilon OS=Rattus norvegicus GN=Ywhae PE=1 SV=1 PF00901 Orbivirus outer capsid protein VP5 -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-5704.0 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5705.0 BF_2 8.00 3.12 393 759111741 XP_011355567.1 206 3.3e-14 PREDICTED: smoothened homolog [Pteropus vampyrus] 300360510 NG_023340.1 390 0 Homo sapiens smoothened, frizzled class receptor (SMO), RefSeqGene on chromosome 7 K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 Q99835 206 1.4e-15 Smoothened homolog OS=Homo sapiens GN=SMO PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5716.1 BF_2 4.00 0.35 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5720.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5722.0 BF_2 20.47 1.21 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5723.0 BF_2 7.00 2.08 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01440 Geminivirus AL2 protein -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-5724.0 BF_2 3.00 0.81 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5733.0 BF_2 5.00 0.54 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5736.0 BF_2 4.00 1.49 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5739.0 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5741.0 BF_2 5.00 0.85 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5748.0 BF_2 9.00 2.05 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5749.0 BF_2 3.00 0.33 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5750.0 BF_2 3.00 0.45 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5752.0 BF_2 4.00 0.51 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5754.0 BF_2 4.41 0.48 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5756.1 BF_2 198.84 15.27 832 642916758 XP_972520.3 516 7.9e-50 PREDICTED: chymotrypsin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35037 343 3.7e-31 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-5761.0 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5764.0 BF_2 9.00 2.07 469 14198259 AAH08189.1 509 2.9e-49 Unknown (protein for IMAGE:3584589), partial [Mus musculus] 357495174 XM_003617828.1 310 9.39549e-160 Medicago truncatula Heat shock protein (MTR_5g096460) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 P36181 511 7.0e-51 Heat shock cognate protein 80 OS=Solanum lycopersicum GN=HSC80 PE=2 SV=1 PF02724//PF00183//PF03896 CDC45-like protein//Hsp90 protein//Translocon-associated protein (TRAP), alpha subunit GO:0006457//GO:0006950//GO:0006270 protein folding//response to stress//DNA replication initiation GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0005789 endoplasmic reticulum membrane KOG0019 Molecular chaperone (HSP90 family) Cluster-5765.0 BF_2 3.00 0.35 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5768.0 BF_2 6.00 0.61 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5769.0 BF_2 6.00 0.86 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5771.0 BF_2 3.00 1.24 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5773.0 BF_2 5.00 0.84 537 -- -- -- -- -- 384381394 JF766606.2 204 9.11885e-101 Juglans regia cultivar Liaoning 2 GAI-like protein (GAI) mRNA, complete cds -- -- -- -- Q8S4W7 410 4.1e-39 DELLA protein GAI1 OS=Vitis vinifera GN=GAI1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5776.0 BF_2 3.00 0.43 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5778.0 BF_2 3.00 0.66 477 61806482 NP_001013473.1 582 1.0e-57 uncharacterized protein LOC541327 [Danio rerio]>gi|528520656|ref|XP_005170704.1| PREDICTED: uncharacterized protein LOC541327 isoform X1 [Danio rerio]>gi|60688538|gb|AAH91562.1| Zgc:114188 [Danio rerio] 156764539 AK287924.1 272 1.27321e-138 Oryza sativa Japonica Group cDNA, clone: J065218C21, full insert sequence K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q90YQ6 568 1.7e-57 40S ribosomal protein S17 OS=Ictalurus punctatus GN=rps17 PE=2 SV=3 PF00833 Ribosomal S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0187 40S ribosomal protein S17 Cluster-5782.0 BF_2 5.00 0.76 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5785.0 BF_2 3.00 0.93 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5786.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5786.1 BF_2 5.00 0.41 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5787.0 BF_2 2.00 0.57 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02056 Family 4 glycosyl hydrolase GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-5788.0 BF_2 4.00 0.99 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5793.0 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5795.0 BF_2 6.00 4.81 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13202//PF13499//PF10591//PF13833//PF13405//PF00036 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-5796.0 BF_2 10.00 1.55 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O04203 468 8.0e-46 Nematode resistance protein-like HSPRO2 OS=Arabidopsis thaliana GN=HSPRO2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5800.0 BF_2 3.00 0.40 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5802.0 BF_2 29.00 1.24 1267 330831790 XP_003291939.1 627 1.6e-62 1,4-alpha-glucan branching enzyme [Dictyostelium purpureum]>gi|325077853|gb|EGC31539.1| 1,4-alpha-glucan branching enzyme [Dictyostelium purpureum] 115446458 NM_001053544.1 1257 0 Oryza sativa Japonica Group Os02g0528200 (Os02g0528200) mRNA, complete cds K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q08047 1181 3.8e-128 1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic OS=Zea mays GN=SBE1 PE=1 SV=1 PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) GO:0005975 carbohydrate metabolic process GO:0004553//GO:0003824 hydrolase activity, hydrolyzing O-glycosyl compounds//catalytic activity -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-5804.0 BF_2 2.00 0.38 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5805.0 BF_2 7.00 1.99 434 156350294 XP_001622225.1 375 9.2e-34 predicted protein [Nematostella vectensis]>gi|156208695|gb|EDO30125.1| predicted protein [Nematostella vectensis] 115452900 NM_001056586.1 315 1.4358e-162 Oryza sativa Japonica Group Os03g0337800 (Os03g0337800) mRNA, complete cds >gnl|BL_ORD_ID|3397255 Oryza sativa Japonica Group cDNA clone:001-025-G06, full insert sequence K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 Q9LUQ6 519 7.6e-52 60S ribosomal protein L19-2 OS=Arabidopsis thaliana GN=RPL19B PE=2 SV=1 PF01280 Ribosomal protein L19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0030529//GO:0005840//GO:0005622 intracellular ribonucleoprotein complex//ribosome//intracellular KOG1696 60s ribosomal protein L19 Cluster-5806.0 BF_2 7.00 1.18 536 826418968 XP_012524350.1 240 5.1e-18 PREDICTED: 30S ribosomal protein S3, chloroplastic-like [Monomorium pharaonis] 528540458 AP012528.1 521 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P46801 480 3.1e-47 60S ribosomal protein L16, mitochondrial OS=Oryza sativa subsp. japonica GN=RPL16 PE=3 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3422 Mitochondrial ribosomal protein L16 Cluster-5807.0 BF_2 9.00 0.94 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5808.3 BF_2 11.00 0.59 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5813.0 BF_2 3.00 2.20 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5817.0 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5819.0 BF_2 1.00 3.05 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5820.0 BF_2 2.00 0.73 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5821.0 BF_2 6.00 0.51 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5825.0 BF_2 12.00 3.65 424 -- -- -- -- -- 608072537 KJ196384.1 49 1.03445e-14 Juglans sigillata histone H3 (H3) mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5828.0 BF_2 6.00 1.63 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5831.0 BF_2 3.00 0.45 563 -- -- -- -- -- 380855527 JQ004258.1 298 5.33969e-153 Portunus trituberculatus thioredoxin 2 (Trx2) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5833.0 BF_2 9.00 0.97 674 38512083 AAH61437.1 384 1.3e-34 40S ribosomal protein S6 [Xenopus (Silurana) tropicalis] 802569845 XM_012212511.1 300 4.99397e-154 PREDICTED: Jatropha curcas 40S ribosomal protein S6-like (LOC105630639), mRNA K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 O48549 541 3.3e-54 40S ribosomal protein S6-1 OS=Arabidopsis thaliana GN=RPS6A PE=1 SV=2 PF01092 Ribosomal protein S6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1646 40S ribosomal protein S6 Cluster-5846.0 BF_2 1.00 0.73 338 564298835 XP_001074464.4 329 1.5e-28 PREDICTED: transmembrane protein 258 [Rattus norvegicus]>gi|564332945|ref|XP_574622.4| PREDICTED: transmembrane protein 258 [Rattus norvegicus]>gi|149062372|gb|EDM12795.1| rCG47273, isoform CRA_b [Rattus norvegicus] 194018428 NM_014206.3 338 1.78903e-175 Homo sapiens transmembrane protein 258 (TMEM258), mRNA -- -- -- -- Q32P84 309 1.3e-27 Transmembrane protein 258 OS=Bos taurus GN=TMEM258 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4452 Predicted membrane protein Cluster-5851.0 BF_2 1.00 1.24 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5855.0 BF_2 3.00 0.56 513 700346190 XP_009917077.1 648 2.4e-65 PREDICTED: elongation factor 1-alpha 1, partial [Haliaeetus albicilla] 819320423 KP245811.1 323 6.12311e-167 Betula luminifera elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 O24534 673 1.2e-69 Elongation factor 1-alpha OS=Vicia faba PE=2 SV=1 PF02774 Semialdehyde dehydrogenase, dimerisation domain GO:0055114//GO:0000051//GO:0008652 oxidation-reduction process//obsolete urea cycle intermediate metabolic process//cellular amino acid biosynthetic process GO:0016620//GO:0046983//GO:0003942 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//protein dimerization activity//N-acetyl-gamma-glutamyl-phosphate reductase activity GO:0005737 cytoplasm KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-5859.0 BF_2 18.00 2.22 626 260813446 XP_002601429.1 154 5.6e-08 hypothetical protein BRAFLDRAFT_281303 [Branchiostoma floridae]>gi|229286724|gb|EEN57441.1| hypothetical protein BRAFLDRAFT_281303 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9LMX7 324 4.5e-29 Cytochrome P450 78A5 OS=Arabidopsis thaliana GN=CYP78A5 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-5859.1 BF_2 18.00 1.38 833 163914959 NP_001106471.1 215 6.3e-15 cytochrome P450, family 2, subfamily U, polypeptide 1 [Xenopus (Silurana) tropicalis]>gi|158254022|gb|AAI54093.1| LOC100127656 protein [Xenopus (Silurana) tropicalis] 595850348 XM_007209835.1 347 4.65219e-180 Prunus persica hypothetical protein (PRUPE_ppa004083mg) mRNA, complete cds -- -- -- -- Q9LMX7 926 9.4e-99 Cytochrome P450 78A5 OS=Arabidopsis thaliana GN=CYP78A5 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-5862.0 BF_2 3.00 6.17 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5864.0 BF_2 1.00 0.57 357 817323404 XP_012332411.1 407 1.5e-37 PREDICTED: amyloid-like protein 2 isoform X2 [Aotus nancymaae] 694947833 XM_009424474.1 357 0 PREDICTED: Pan troglodytes amyloid beta (A4) precursor-like protein 2 (APLP2), transcript variant X3, mRNA K08117 APLP2 amyloid beta (A4) precursor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08117 Q06481 384 2.8e-36 Amyloid-like protein 2 OS=Homo sapiens GN=APLP2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-5865.0 BF_2 5.00 3.88 334 -- -- -- -- -- 221554531 NG_009445.1 334 2.95443e-173 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5873.0 BF_2 8.00 1.86 467 664778345 XP_008508489.1 276 3.0e-22 PREDICTED: guanine nucleotide-binding protein subunit alpha-11-like [Equus przewalskii] 157841359 AC206587.3 467 0 Homo sapiens FOSMID clone ABC9-41277500N5 from chromosome 19, complete sequence K04635 GNA11 guanine nucleotide-binding protein subunit alpha-11 http://www.genome.jp/dbget-bin/www_bget?ko:K04635 P29992 267 1.4e-22 Guanine nucleotide-binding protein subunit alpha-11 OS=Homo sapiens GN=GNA11 PE=1 SV=2 PF00503 G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0003924//GO:0031683//GO:0019001//GO:0004871 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-5876.0 BF_2 91.00 3.93 1256 344270434 XP_003407049.1 454 1.8e-42 PREDICTED: aquaporin-1 [Loxodonta africana] 238814669 FJ971054.1 899 0 Juglans regia plasma intrinsic protein 1;2 mRNA, complete cds K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 P25794 1374 1.6e-150 Probable aquaporin PIP-type 7a OS=Pisum sativum GN=TRG-31 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-5877.0 BF_2 25.00 1.13 1215 407410828 EKF33129.1 356 4.1e-31 thymine-7-hydroxylase, putative [Trypanosoma cruzi marinkellei] 238625280 FJ966204.1 941 0 Juglans regia flavanone 3-hydroxylase (F3H) mRNA, partial cds -- -- -- -- Q9S818 1408 1.8e-154 Naringenin,2-oxoglutarate 3-dioxygenase OS=Arabidopsis thaliana GN=F3H PE=1 SV=1 PF03171 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-5886.0 BF_2 2.00 0.44 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5892.0 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5897.0 BF_2 3.00 1.84 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5904.0 BF_2 8.00 1.37 531 831772114 XP_012753508.1 235 1.9e-17 hypothetical protein SAMD00019534_069420 [Acytostelium subglobosum LB1]>gi|735854140|dbj|GAM23767.1| hypothetical protein SAMD00019534_069420 [Acytostelium subglobosum LB1] 530722998 KC140116.1 531 0 Oryza sativa Japonica Group clone KCS071C11 translocase of chloroplast 34 mRNA, complete cds; nuclear gene for chloroplast product -- -- -- -- Q38906 627 2.8e-64 Translocase of chloroplast 34, chloroplastic OS=Arabidopsis thaliana GN=TOC34 PE=1 SV=2 PF04548//PF01926 AIG1 family//50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- -- -- Cluster-5905.0 BF_2 3.00 0.60 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5907.0 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5914.0 BF_2 6.00 0.46 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5917.0 BF_2 7.00 4.02 356 296200978 XP_002747844.1 572 1.1e-56 PREDICTED: putative 60S ribosomal protein L37a [Callithrix jacchus] 694898640 XM_516077.4 356 0 PREDICTED: Pan troglodytes ribosomal protein L37a (RPL37A), mRNA K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 P61513 485 5.5e-48 60S ribosomal protein L37a OS=Homo sapiens GN=RPL37A PE=1 SV=2 PF06689//PF01780 ClpX C4-type zinc finger//Ribosomal L37ae protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0046983//GO:0003735//GO:0008270 protein dimerization activity//structural constituent of ribosome//zinc ion binding GO:0005622//GO:0005840 intracellular//ribosome KOG0402 60S ribosomal protein L37 Cluster-5924.0 BF_2 18.21 1.72 730 815820320 XP_012231375.1 140 2.8e-06 PREDICTED: lipase 3-like [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-5928.0 BF_2 3.00 0.89 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5929.0 BF_2 5.00 0.45 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5939.0 BF_2 5.00 0.74 569 847163228 XP_012825773.1 501 3.0e-48 PREDICTED: 40S ribosomal protein S2 isoform X1 [Xenopus (Silurana) tropicalis] 115456088 NM_001058180.1 569 0 Oryza sativa Japonica Group Os03g0807800 (Os03g0807800) mRNA, complete cds K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P49688 590 5.8e-60 40S ribosomal protein S2-3 OS=Arabidopsis thaliana GN=RPS2C PE=1 SV=2 PF03719 Ribosomal protein S5, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-5941.0 BF_2 3.00 0.41 594 387762416 BAM15639.1 562 2.6e-55 high-affinity dopamine transporter [Gryllus bimaculatus] -- -- -- -- -- K05035 SLC6A2 solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05035 O55192 375 5.2e-35 Sodium-dependent noradrenaline transporter OS=Mus musculus GN=Slc6a2 PE=2 SV=2 PF12131//PF00209 Protein of unknown function (DUF3586)//Sodium:neurotransmitter symporter family GO:0006812//GO:0006836//GO:0006508 cation transport//neurotransmitter transport//proteolysis GO:0004197//GO:0005328 cysteine-type endopeptidase activity//neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-5949.0 BF_2 3.00 0.53 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5952.0 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5953.0 BF_2 2.00 0.32 551 646716744 KDR19870.1 263 1.1e-20 Lactadherin [Zootermopsis nevadensis] 367067192 JQ021072.1 85 1.32922e-34 Pinus taeda isolate 1650 hypothetical protein (2_9228_01) gene, partial cds -- -- -- -- -- -- -- -- PF12749//PF00008//PF00098 Eukaryotic metallothionein//EGF-like domain//Zinc knuckle -- -- GO:0008270//GO:0003676//GO:0005515//GO:0046872 zinc ion binding//nucleic acid binding//protein binding//metal ion binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-5956.0 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5960.0 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5962.0 BF_2 9.00 10.33 311 524883624 XP_005098439.1 351 4.0e-31 PREDICTED: 60S ribosomal protein L23 isoform X1 [Aplysia californica] 116635331 CT834193.1 311 1.66564e-160 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCEA012E06, full insert sequence K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P49690 390 4.9e-37 60S ribosomal protein L23 OS=Arabidopsis thaliana GN=RPL23A PE=2 SV=3 PF00238 Ribosomal protein L14p/L23e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-5966.0 BF_2 8.00 5.09 348 -- -- -- -- -- 385718871 JF969237.1 348 0 Oryza sativa clone KCB711H10 Sucrose synthase 2 mRNA, complete cds -- -- -- -- P30298 620 1.2e-63 Sucrose synthase 2 OS=Oryza sativa subsp. japonica GN=SUS2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-5968.0 BF_2 2.00 0.55 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5970.0 BF_2 1.00 1.29 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5975.0 BF_2 3.00 0.44 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5977.0 BF_2 4.00 0.33 797 795432803 XP_011949448.1 1256 1.2e-135 PREDICTED: calreticulin [Cercocebus atys] 209862753 NM_004343.3 797 0 Homo sapiens calreticulin (CALR), mRNA K08057 CALR calreticulin http://www.genome.jp/dbget-bin/www_bget?ko:K08057 Q4R6K8 1256 4.9e-137 Calreticulin OS=Macaca fascicularis GN=CALR PE=2 SV=1 PF00262 Calreticulin family GO:0006457 protein folding GO:0005509//GO:0051082 calcium ion binding//unfolded protein binding GO:0005783 endoplasmic reticulum KOG0674 Calreticulin Cluster-5977.1 BF_2 1.00 0.33 414 635036434 XP_007993643.1 546 1.3e-53 PREDICTED: calreticulin [Chlorocebus sabaeus] 649098882 KJ890816.1 414 0 Synthetic construct Homo sapiens clone ccsbBroadEn_00210 CALR gene, encodes complete protein K08057 CALR calreticulin http://www.genome.jp/dbget-bin/www_bget?ko:K08057 Q2HWU3 546 5.4e-55 Calreticulin OS=Macaca fuscata fuscata GN=CALR PE=2 SV=1 PF00262 Calreticulin family GO:0006457 protein folding GO:0051082//GO:0005509 unfolded protein binding//calcium ion binding GO:0005783 endoplasmic reticulum KOG0674 Calreticulin Cluster-5980.0 BF_2 11.00 2.08 508 873225009 CEM24753.1 618 7.2e-62 unnamed protein product [Vitrella brassicaformis CCMP3155] 115451516 NM_001055894.1 448 0 Oryza sativa Japonica Group Os03g0213100 (Os03g0213100) mRNA, complete cds K10956 SEC61A protein transport protein SEC61 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10956 Q54XK2 558 2.7e-56 Protein transport protein Sec61 subunit alpha OS=Dictyostelium discoideum GN=sec61a PE=3 SV=1 PF00344 SecY translocase GO:0015031 protein transport -- -- GO:0016020 membrane KOG1373 Transport protein Sec61, alpha subunit Cluster-5982.0 BF_2 16.03 0.72 1221 546685810 ERL95253.1 796 4.0e-82 hypothetical protein D910_12520 [Dendroctonus ponderosae] -- -- -- -- -- K14410 ACP2 lysosomal acid phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14410 B1H1P9 518 2.8e-51 Lysosomal acid phosphatase OS=Xenopus laevis GN=acp2 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-5985.0 BF_2 8.00 0.79 711 -- -- -- -- -- 731432277 XM_002284698.3 182 2.08302e-88 PREDICTED: Vitis vinifera uncharacterized LOC100260721 (LOC100260721), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5987.0 BF_2 6.00 4.73 333 820968660 XP_012370391.1 248 3.8e-19 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [Octodon degus] 383209645 NG_007466.2 333 1.05907e-172 Homo sapiens phosphatase and tensin homolog (PTEN), RefSeqGene (LRG_311) on chromosome 10 K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60483 248 1.5e-20 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Canis familiaris GN=PTEN PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5990.0 BF_2 3.00 0.56 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-5991.0 BF_2 93.00 13.15 583 -- -- -- -- -- 297725478 NM_001188174.1 498 0 Oryza sativa Japonica Group Os07g0220050 (Os07g0220050) mRNA, complete cds -- -- -- -- P0C5E5 352 2.4e-32 Prolamin PPROL 14E OS=Oryza sativa subsp. indica PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-5993.0 BF_2 3.00 0.32 680 242022148 XP_002431503.1 362 4.7e-32 enzymatic polyprotein; Endonuclease; Reverse transcriptase, putative [Pediculus humanus corporis]>gi|212516797|gb|EEB18765.1| enzymatic polyprotein; Endonuclease; Reverse transcriptase, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- P10394 239 3.5e-19 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- GO:0006259 DNA metabolic process GO:0016779//GO:0003676 nucleotidyltransferase activity//nucleic acid binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-5997.0 BF_2 7.00 2.78 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12861//PF13639//PF17122//PF00097//PF12906//PF12678//PF17123//PF14634 Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-5998.0 BF_2 5.00 0.69 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6008.0 BF_2 10.00 1.48 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6016.0 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6019.0 BF_2 2.00 0.64 418 470299131 XP_004346362.1 253 1.2e-19 beta-galactosidase [Capsaspora owczarzaki ATCC 30864]>gi|765554593|gb|KJE95214.1| beta-galactosidase [Capsaspora owczarzaki ATCC 30864] 743905144 XM_011047664.1 153 1.56572e-72 PREDICTED: Populus euphratica beta-galactosidase-like (LOC105140720), transcript variant X2, mRNA -- -- -- -- P45582 533 1.7e-53 Beta-galactosidase OS=Asparagus officinalis PE=2 SV=1 PF02140 Galactose binding lectin domain -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-6020.0 BF_2 10.00 0.89 758 426281759 AFY23984.1 1200 3.5e-129 actin, partial [Stemonaria longa] 182409984 EU588981.1 659 0 Betula platyphylla actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P46258 1219 9.0e-133 Actin-3 OS=Pisum sativum PE=2 SV=1 PF03141 Putative S-adenosyl-L-methionine-dependent methyltransferase -- -- GO:0008168 methyltransferase activity -- -- KOG0676 Actin and related proteins Cluster-6021.0 BF_2 9.00 2.97 413 823431831 XP_012422566.1 613 2.2e-61 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101368878 [Odobenus rosmarus divergens] 724800413 KM454863.1 278 5.03406e-142 Betula luminifera histone H3 protein mRNA, complete cds K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 Q0JCT1 627 2.2e-64 Histone H3.3 OS=Oryza sativa subsp. japonica GN=H3 PE=1 SV=2 PF00125//PF15715 Core histone H2A/H2B/H3/H4//PCNA-associated factor GO:0051726//GO:0006974 regulation of cell cycle//cellular response to DNA damage stimulus GO:0003677 DNA binding -- -- -- -- Cluster-6022.0 BF_2 3.00 0.47 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6026.0 BF_2 1.00 1.24 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6031.0 BF_2 3.00 0.31 689 642931903 XP_008196775.1 419 1.2e-38 PREDICTED: mutS protein homolog 4-like [Tribolium castaneum] -- -- -- -- -- K08740 MSH4 DNA mismatch repair protein MSH4 http://www.genome.jp/dbget-bin/www_bget?ko:K08740 Q99MT2 225 1.5e-17 MutS protein homolog 4 OS=Mus musculus GN=Msh4 PE=2 SV=1 PF05188 MutS domain II GO:0006298 mismatch repair GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- -- -- Cluster-6033.0 BF_2 4.00 0.32 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6038.0 BF_2 3.00 0.55 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6044.0 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6045.0 BF_2 6.00 1.03 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6046.0 BF_2 3.00 0.80 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6048.0 BF_2 2.00 0.32 552 642912818 XP_008201265.1 289 1.1e-23 PREDICTED: synaptic vesicle glycoprotein 2B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6049.0 BF_2 4.00 0.41 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6052.0 BF_2 4.00 0.39 721 817054359 XP_012267140.1 754 1.7e-77 PREDICTED: acyl-CoA Delta(11) desaturase-like [Athalia rosae] 829569648 NM_001309579.1 35 1.10131e-06 Bombyx mori acyl-CoA Delta(11) desaturase-like (LOC101741176), mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 630 1.7e-64 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-6053.0 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6054.0 BF_2 3.00 0.46 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6055.2 BF_2 5.00 1.08 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6058.1 BF_2 3.00 0.41 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6060.0 BF_2 8.00 0.87 671 330844029 XP_003293941.1 502 2.7e-48 S-adenosylmethionine synthetase [Dictyostelium purpureum]>gi|325075674|gb|EGC29533.1| S-adenosylmethionine synthetase [Dictyostelium purpureum] 541135568 KC204976.1 356 0 Betula luminifera S-adenosylmethionine synthetase 1 (SAMS1) mRNA, complete cds K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 A7NVX9 766 2.7e-80 S-adenosylmethionine synthase 2 OS=Vitis vinifera GN=METK2 PE=3 SV=1 PF02773 S-adenosylmethionine synthetase, C-terminal domain GO:0044281//GO:0044249//GO:1901576//GO:0006555//GO:0006556 small molecule metabolic process//cellular biosynthetic process//organic substance biosynthetic process//methionine metabolic process//S-adenosylmethionine biosynthetic process GO:0016740//GO:0004478//GO:0000166//GO:0043167 transferase activity//methionine adenosyltransferase activity//nucleotide binding//ion binding -- -- KOG1506 S-adenosylmethionine synthetase Cluster-6061.0 BF_2 2.00 0.38 507 795307910 XP_011823578.1 620 4.2e-62 PREDICTED: protein S100-A4 isoform X1 [Mandrillus leucophaeus] 158257597 AK292083.1 507 0 Homo sapiens cDNA FLJ76571 complete cds, highly similar to Homo sapiens S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) (S100A4), transcript variant 1, mRNA -- -- -- -- P26447 533 2.1e-53 Protein S100-A4 OS=Homo sapiens GN=S100A4 PE=1 SV=1 PF12763//PF13202//PF13499//PF13833//PF00036//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-6066.0 BF_2 3.00 0.39 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-6067.0 BF_2 8.00 6.51 331 -- -- -- -- -- 116012448 AK243083.1 325 2.94575e-168 Oryza sativa Japonica Group cDNA, clone: J100020K24, full insert sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6069.0 BF_2 1.00 0.34 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6070.1 BF_2 4.00 0.32 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6071.0 BF_2 2.00 0.55 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6072.0 BF_2 1.00 1.66 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6084.0 BF_2 20.39 0.58 1758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6085.0 BF_2 4.00 0.32 804 478258278 ENN78407.1 974 6.0e-103 hypothetical protein YQE_05207, partial [Dendroctonus ponderosae] -- -- -- -- -- K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 843 3.8e-89 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1079 Transcriptional repressor EZH1 Cluster-6095.0 BF_2 5.00 0.83 538 821026945 XP_012356733.1 212 9.1e-15 PREDICTED: LOW QUALITY PROTEIN: ALK tyrosine kinase receptor [Nomascus leucogenys] 221554531 NG_009445.1 538 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 212 3.8e-16 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-6102.0 BF_2 15.00 5.41 402 686768794 XP_002832405.3 515 5.0e-50 PREDICTED: discoidin domain-containing receptor 2-like [Pongo abelii] 282721095 NG_016290.1 402 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 418 3.6e-40 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-6105.0 BF_2 4.00 0.31 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6110.0 BF_2 10.00 1.75 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6113.0 BF_2 2.00 0.49 459 642939204 XP_008200381.1 269 1.9e-21 PREDICTED: uncharacterized protein LOC103314902 [Tribolium castaneum]>gi|270016356|gb|EFA12802.1| hypothetical protein TcasGA2_TC001865 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-6118.0 BF_2 8.00 3.91 370 444524089 ELV13716.1 243 1.6e-18 ALK tyrosine kinase receptor, partial [Tupaia chinensis] 221554531 NG_009445.1 370 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 231 1.6e-18 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-6119.0 BF_2 4.71 0.77 542 148669489 EDL01436.1 518 3.0e-50 mCG7861, isoform CRA_a, partial [Mus musculus] 214829145 NM_033022.3 542 0 Homo sapiens ribosomal protein S24 (RPS24), transcript variant a, mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 P62847 507 2.3e-50 40S ribosomal protein S24 OS=Homo sapiens GN=RPS24 PE=1 SV=1 PF01282 Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3424 40S ribosomal protein S24 Cluster-6123.0 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6125.0 BF_2 6.00 0.71 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10034 Q-cell neuroblast polarisation -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-6126.0 BF_2 3.00 0.32 675 541906785 AGV28714.1 155 4.6e-08 period [Eurydice pulchra] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-6129.1 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6133.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6134.0 BF_2 2.00 0.75 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6135.0 BF_2 9.00 5.89 346 565308749 ETE62511.1 203 6.5e-14 Fibroblast growth factor receptor 1, partial [Ophiophagus hannah] 254553324 NG_012449.1 346 6.55674e-180 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q90330 140 5.4e-08 Fibroblast growth factor receptor 4 OS=Coturnix coturnix GN=FGFR4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6138.0 BF_2 3.00 0.46 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6139.0 BF_2 1.00 0.67 344 488546466 XP_004464750.1 450 1.5e-42 PREDICTED: ubiquitin-like protein 5 [Dasypus novemcinctus] 694972879 XM_512356.5 344 8.42748e-179 PREDICTED: Pan troglodytes ubiquitin-like 5 (UBL5), transcript variant X2, mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q3T0Z3 394 1.9e-37 Ubiquitin-like protein 5 OS=Bos taurus GN=UBL5 PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-6145.0 BF_2 4.00 0.41 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6147.0 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6148.0 BF_2 3.00 1.35 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6150.0 BF_2 2.00 0.79 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6159.0 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6162.0 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6176.0 BF_2 14.00 1.04 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6182.0 BF_2 10.00 0.52 1091 119587704 EAW67300.1 1076 1.2e-114 transgelin, isoform CRA_c [Homo sapiens] 62205325 BC093050.1 1090 0 Homo sapiens transgelin, mRNA (cDNA clone MGC:111120 IMAGE:30396619), complete cds -- -- -- -- Q01995 1051 3.9e-113 Transgelin OS=Homo sapiens GN=TAGLN PE=1 SV=4 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-6184.1 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6185.0 BF_2 4.00 0.33 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6189.0 BF_2 6.00 0.60 705 270003844 EFA00292.1 367 1.3e-32 hypothetical protein TcasGA2_TC003125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P9WQ36 208 1.4e-15 Long-chain-fatty-acid--CoA ligase FadD13 OS=Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh) GN=fadD13 PE=3 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-6193.0 BF_2 4.29 1.60 398 119607362 EAW86956.1 480 5.6e-46 hCG1983635 [Homo sapiens] 5922025 AC008040.7 308 1.01747e-158 Homo sapiens 3 BAC RP11-379K17 (Roswell Park Cancer Institue Human BAC Library) complete sequence -- -- -- -- O00370 403 2.0e-38 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6195.0 BF_2 17.00 39.61 279 -- -- -- -- -- 24211084 AC121489.2 189 9.72518e-93 Oryza sativa Japonica Group chromosome 3 clone OJ1217B09, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6196.0 BF_2 3.00 0.72 461 675791461 XP_008952684.1 635 7.0e-64 PREDICTED: LOW QUALITY PROTEIN: glutathione peroxidase 3 [Pan paniscus]>gi|2160390|dbj|BAA00525.1| glutathione peroxidase [Homo sapiens] 675791460 XM_008954436.1 461 0 PREDICTED: Pan paniscus glutathione peroxidase 3 (plasma) (GPX3), mRNA K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 P22352 635 2.9e-65 Glutathione peroxidase 3 OS=Homo sapiens GN=GPX3 PE=1 SV=2 PF00255 Glutathione peroxidase GO:0002238//GO:0055114//GO:0006979//GO:0006804//GO:0006749//GO:0051289//GO:0010269//GO:0042493//GO:0007565//GO:0042744//GO:0006982//GO:0051412 response to molecule of fungal origin//oxidation-reduction process//response to oxidative stress//obsolete peroxidase reaction//glutathione metabolic process//protein homotetramerization//response to selenium ion//response to drug//female pregnancy//hydrogen peroxide catabolic process//response to lipid hydroperoxide//response to corticosterone GO:0008430//GO:0008134//GO:0004602//GO:0043295 selenium binding//transcription factor binding//glutathione peroxidase activity//glutathione binding GO:0005615//GO:0005667 extracellular space//transcription factor complex KOG1651 Glutathione peroxidase Cluster-6198.0 BF_2 20.19 0.68 1529 -- -- -- -- -- 157283802 EF653034.1 40 3.97818e-09 Platanus x acerifolia isolate F11T.24-st NBS-containing resistance-like protein pseudogene, complete sequence -- -- -- -- Q40392 394 8.4e-37 TMV resistance protein N OS=Nicotiana glutinosa GN=N PE=1 SV=1 PF13676//PF01582//PF01637//PF00004//PF00931 TIR domain//TIR domain//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//NB-ARC domain GO:0007165 signal transduction GO:0043531//GO:0005515//GO:0005524 ADP binding//protein binding//ATP binding -- -- -- -- Cluster-6202.0 BF_2 1.00 0.54 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13008 Zinc-binding domain of Paramyxoviridae V protein -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-6205.0 BF_2 11.00 1.11 700 873224455 CEM26305.1 643 1.2e-64 unnamed protein product [Vitrella brassicaformis CCMP3155] 568881905 XM_006493727.1 318 5.12384e-164 PREDICTED: Citrus sinensis phosphoglycerate kinase, cytosolic-like (LOC102611752), mRNA K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q42962 773 4.3e-81 Phosphoglycerate kinase, cytosolic OS=Nicotiana tabacum PE=2 SV=1 PF06506//PF00162 Propionate catabolism activator//Phosphoglycerate kinase GO:0015976//GO:0006094//GO:0000160//GO:0006096//GO:0016310 carbon utilization//gluconeogenesis//phosphorelay signal transduction system//glycolytic process//phosphorylation GO:0000156//GO:0003677//GO:0005524//GO:0004618 phosphorelay response regulator activity//DNA binding//ATP binding//phosphoglycerate kinase activity -- -- KOG1367 3-phosphoglycerate kinase Cluster-6207.0 BF_2 3.00 0.33 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6211.0 BF_2 9.00 16.42 289 290462013 ADD24054.1 357 7.5e-32 Probable 60S ribosomal protein L37-A [Lepeophtheirus salmonis]>gi|290561134|gb|ADD37969.1| Probable 60S ribosomal protein L37-A [Lepeophtheirus salmonis] 156765815 AK289200.1 289 2.60321e-148 Oryza sativa Japonica Group cDNA, clone: J100049D22, full insert sequence K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q8LEM8 397 7.1e-38 60S ribosomal protein L37-3 OS=Arabidopsis thaliana GN=RPL37C PE=3 SV=1 PF01907 Ribosomal protein L37e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0046872//GO:0003735//GO:0019843 metal ion binding//structural constituent of ribosome//rRNA binding GO:0005622//GO:0005840 intracellular//ribosome KOG3475 60S ribosomal protein L37 Cluster-6212.0 BF_2 6.00 1.46 459 -- -- -- -- -- 164454795 AB289596.1 152 6.23101e-72 Rhododendron x pulchrum RpANS mRNA for anthocyanidin synthase, partial cds -- -- -- -- P51091 406 1.0e-38 Leucoanthocyanidin dioxygenase OS=Malus domestica GN=ANS PE=2 SV=1 PF03171 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-6214.0 BF_2 2.00 23.67 229 -- -- -- -- -- 531874317 KC202293.1 229 4.52572e-115 Oryza sativa Indica Group isolate OsIGluA3 glutelin mRNA, partial cds -- -- -- -- Q09151 285 5.5e-25 Glutelin type-A 3 OS=Oryza sativa subsp. japonica GN=GLUA3 PE=2 SV=2 PF00190//PF10541 Cupin//Nuclear envelope localisation domain -- -- GO:0045735 nutrient reservoir activity GO:0016021 integral component of membrane -- -- Cluster-6216.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6217.0 BF_2 3.00 9.41 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6220.0 BF_2 22.00 1.47 914 695721329 4UX8 437 1.3e-40 Chain A, Ret Recognition Of Gdnf-gfralpha1 Ligand By A Composite Binding Site Promotes Membrane-proximal Self-association>gi|695721330|pdb|4UX8|B Chain B, Ret Recognition Of Gdnf-gfralpha1 Ligand By A Composite Binding Site Promotes Membrane-proximal Self-association 5419752 AJ243297.1 912 0 Homo sapiens partial RET gene, exons 2 to 20 K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 437 5.2e-42 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-6221.0 BF_2 1.00 0.46 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6222.0 BF_2 25.00 1.48 994 484759882 YP_007890491.1 159 2.4e-08 ribosomal protein S14 (mitochondrion) [Andalucia godoyi]>gi|462269113|gb|AGH23985.1| ribosomal protein S14 (mitochondrion) [Andalucia godoyi] 528540420 AP012527.1 988 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT98C -- -- -- -- P51409 423 2.4e-40 60S ribosomal protein L5, mitochondrial OS=Solanum tuberosum GN=RPL5 PE=2 SV=2 PF02888//PF00253 Calmodulin binding domain//Ribosomal protein S14p/S29e GO:0006813//GO:0006412//GO:0042254 potassium ion transport//translation//ribosome biogenesis GO:0015269//GO:0005516//GO:0003735 calcium-activated potassium channel activity//calmodulin binding//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular -- -- Cluster-6223.0 BF_2 2.00 0.60 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6227.0 BF_2 1.00 0.51 366 675369362 KFM62264.1 540 5.8e-53 Ankyrin-2, partial [Stegodyphus mimosarum] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 O70511 378 1.4e-35 Ankyrin-3 OS=Rattus norvegicus GN=Ank3 PE=1 SV=3 PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003713//GO:0003677 transcription coactivator activity//DNA binding GO:0005667 transcription factor complex KOG4177 Ankyrin Cluster-6228.0 BF_2 13.00 2.33 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6229.0 BF_2 5.00 0.61 630 340386724 XP_003391858.1 332 1.3e-28 PREDICTED: serine--glyoxylate aminotransferase-like [Amphimedon queenslandica] 720069990 XM_010279297.1 269 7.94909e-137 PREDICTED: Nelumbo nucifera serine--glyoxylate aminotransferase (LOC104611993), transcript variant X2, mRNA -- -- -- -- Q56YA5 751 1.4e-78 Serine--glyoxylate aminotransferase OS=Arabidopsis thaliana GN=AGT1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-6231.0 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6233.0 BF_2 16.58 1.04 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6234.0 BF_2 3.00 0.75 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6239.0 BF_2 21.00 2.70 612 -- -- -- -- -- 46879197 AC134933.2 602 0 Oryza sativa Japonica Group chromosome 5 clone P0579A05, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6241.0 BF_2 3.00 0.47 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6242.0 BF_2 7.00 1.01 577 576697983 EUB61520.1 279 1.7e-22 Cytochrome b5 [Echinococcus granulosus]>gi|674562742|emb|CDS22998.1| cytochrome B5 [Echinococcus granulosus] 590713946 XM_007049716.1 200 1.64725e-98 Theobroma cacao Cytochrome B5, n4,ATCB5-B,CB5-B (TCM_002942) mRNA, complete cds -- -- -- -- P49099 601 3.1e-61 Cytochrome b5, seed isoform OS=Nicotiana tabacum PE=2 SV=1 PF00964 Elicitin GO:0009405//GO:0006952 pathogenesis//defense response -- -- GO:0005576 extracellular region KOG0537 Cytochrome b5 Cluster-6247.0 BF_2 3.00 0.39 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6248.0 BF_2 7.00 0.90 612 443687431 ELT90413.1 337 3.3e-29 hypothetical protein CAPTEDRAFT_52932, partial [Capitella teleta] 39777533 AY443341.1 413 0 Quercus suber phenylalanine ammonia-lyase (PAL) mRNA, complete cds -- -- -- -- O64963 980 3.8e-105 Phenylalanine ammonia-lyase 1 OS=Prunus avium GN=PAL1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6249.0 BF_2 4.00 1.42 404 74961114 O97398.1 262 1.1e-20 RecName: Full=Chymotrypsin; Flags: Precursor [Phaedon cochleariae]>gi|4210802|emb|CAA76928.1| chymotrypsin [Phaedon cochleariae] -- -- -- -- -- K01353 GZMB granzyme B http://www.genome.jp/dbget-bin/www_bget?ko:K01353 O97398 262 4.5e-22 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-6252.0 BF_2 7.00 3.88 359 817342077 XP_012296573.1 262 9.7e-21 PREDICTED: platelet-derived growth factor receptor alpha isoform X2 [Aotus nancymaae] 219521916 NG_009250.1 359 0 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), RefSeqGene (LRG_309) on chromosome 4 K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 P16234 262 4.0e-22 Platelet-derived growth factor receptor alpha OS=Homo sapiens GN=PDGFRA PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-6255.0 BF_2 4.00 1.16 431 821392721 XP_012388291.1 470 8.8e-45 PREDICTED: 60S ribosomal protein L35 isoform X1 [Orcinus orca] 158255579 AK291072.1 431 0 Homo sapiens cDNA FLJ76395 complete cds, highly similar to Homo sapiens ribosomal protein L35 (RPL35), mRNA K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 P42766 470 3.6e-46 60S ribosomal protein L35 OS=Homo sapiens GN=RPL35 PE=1 SV=2 PF00831 Ribosomal L29 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3436 60S ribosomal protein L35 Cluster-6256.0 BF_2 12.00 3.38 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6257.0 BF_2 2.00 0.31 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6259.0 BF_2 16.00 1.29 807 558212964 XP_006134112.1 216 4.7e-15 PREDICTED: LOW QUALITY PROTEIN: fibroblast growth factor receptor 1 [Pelodiscus sinensis] 188219627 NG_007729.1 807 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P16092 209 1.3e-15 Fibroblast growth factor receptor 1 OS=Mus musculus GN=Fgfr1 PE=1 SV=2 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-6260.0 BF_2 24.00 65.51 273 -- -- -- -- -- 20279375 AC103891.2 273 1.91351e-139 Oryza sativa Japonica Group chromosome 3 clone OJ1175C11, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6261.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6266.0 BF_2 12.00 0.97 804 91080103 XP_966802.1 354 4.7e-31 PREDICTED: uncharacterized protein LOC655193 [Tribolium castaneum]>gi|270004659|gb|EFA01107.1| hypothetical protein TcasGA2_TC004032 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6268.0 BF_2 3.00 1.06 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6271.0 BF_2 1.00 0.34 408 156396691 XP_001637526.1 357 1.1e-31 predicted protein [Nematostella vectensis]>gi|156224639|gb|EDO45463.1| predicted protein [Nematostella vectensis] -- -- -- -- -- K01488 add, ADA adenosine deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01488 Q5ZKP6 337 9.1e-31 Adenosine deaminase OS=Gallus gallus GN=ADA PE=2 SV=1 PF00962//PF01979 Adenosine/AMP deaminase//Amidohydrolase family -- -- GO:0016787//GO:0019239 hydrolase activity//deaminase activity -- -- KOG1097 Adenine deaminase/adenosine deaminase Cluster-6279.0 BF_2 43.00 1.33 1641 189235006 XP_970364.2 758 1.4e-77 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|642915168|ref|XP_008190502.1| PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|642915170|ref|XP_008190503.1| PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|642915172|ref|XP_008190504.1| PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|642915174|ref|XP_008190505.1| PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|270003934|gb|EFA00382.1| hypothetical protein TcasGA2_TC003228 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58354 483 4.3e-47 Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus GN=SLC2A8 PE=2 SV=2 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-6283.0 BF_2 4.00 0.55 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6284.0 BF_2 5.00 1.66 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6288.0 BF_2 122.00 2.14 2676 573880189 XP_006628303.1 1923 1.8e-212 PREDICTED: 1,4-alpha-glucan-branching enzyme-like [Lepisosteus oculatus] 115470059 NM_001065164.1 2670 0 Oryza sativa Japonica Group Os06g0726400 (Os06g0726400) mRNA, complete cds K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q01401 4089 0.0e+00 1,4-alpha-glucan-branching enzyme, chloroplastic/amyloplastic OS=Oryza sativa subsp. japonica GN=SBE1 PE=1 SV=2 PF02922//PF00128//PF02806 Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//Alpha amylase, catalytic domain//Alpha amylase, C-terminal all-beta domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169//GO:0004553 catalytic activity//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-6289.0 BF_2 2.00 0.83 386 270015354 EFA11802.1 188 4.0e-12 hypothetical protein TcasGA2_TC008581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 155 1.1e-09 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF02190 ATP-dependent protease La (LON) substrate-binding domain GO:0006508//GO:0006510 proteolysis//obsolete ATP-dependent proteolysis GO:0004176 ATP-dependent peptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-6292.0 BF_2 3.00 0.34 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6295.0 BF_2 3.00 0.69 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6308.0 BF_2 51.00 2.24 1240 873224455 CEM26305.1 1220 2.7e-131 unnamed protein product [Vitrella brassicaformis CCMP3155] 116632775 CT832579.1 1240 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCSN081D18, full insert sequence K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 P12783 1614 2.3e-178 Phosphoglycerate kinase, cytosolic OS=Triticum aestivum PE=2 SV=1 PF00162 Phosphoglycerate kinase GO:0016310//GO:0006096//GO:0006094//GO:0015976 phosphorylation//glycolytic process//gluconeogenesis//carbon utilization GO:0004618 phosphoglycerate kinase activity -- -- KOG1367 3-phosphoglycerate kinase Cluster-6311.0 BF_2 3.00 0.52 530 -- -- -- -- -- 758200060 XM_011324092.1 530 0 Fusarium graminearum PH-1 hypothetical protein mRNA -- -- -- -- -- -- -- -- PF16850//PF01372 Peptidase inhibitor I66//Melittin GO:0045859 regulation of protein kinase activity GO:0004860//GO:0004867 protein kinase inhibitor activity//serine-type endopeptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-6314.0 BF_2 2.00 0.55 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6315.0 BF_2 2.00 1.92 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6318.0 BF_2 9.00 0.76 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6320.0 BF_2 6.00 1.17 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6323.0 BF_2 5.00 1.34 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6325.0 BF_2 2.00 0.40 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6326.0 BF_2 14.00 2.87 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6327.0 BF_2 17.00 1.59 734 443702669 ELU00590.1 534 5.7e-52 hypothetical protein CAPTEDRAFT_171855 [Capitella teleta] 114848913 DQ978224.1 734 0 Oryza sativa (indica cultivar-group) cultivar Taichung Native 1 UDP-glucose pyrophosphorylase mRNA, complete cds K00963 UGP2, galU, galF UTP--glucose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00963 Q43772 835 2.9e-88 UTP--glucose-1-phosphate uridylyltransferase OS=Hordeum vulgare PE=2 SV=1 PF01704 UTP--glucose-1-phosphate uridylyltransferase GO:0008152 metabolic process GO:0070569 uridylyltransferase activity -- -- KOG2638 UDP-glucose pyrophosphorylase Cluster-6333.0 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6334.0 BF_2 39.00 2.03 1090 677286263 AIM46989.1 1073 2.7e-114 translation elongation factor 1-alpha [Colponema vietnamica] 353259712 JN399225.1 513 0 Rosa multiflora elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 O24534 1249 4.3e-136 Elongation factor 1-alpha OS=Vicia faba PE=2 SV=1 PF03144//PF02774 Elongation factor Tu domain 2//Semialdehyde dehydrogenase, dimerisation domain GO:0055114//GO:0008652//GO:0000051 oxidation-reduction process//cellular amino acid biosynthetic process//obsolete urea cycle intermediate metabolic process GO:0016620//GO:0003942//GO:0005525//GO:0046983 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//N-acetyl-gamma-glutamyl-phosphate reductase activity//GTP binding//protein dimerization activity GO:0005737 cytoplasm KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-6335.0 BF_2 52.00 375.94 242 -- -- -- -- -- 193848551 EU730900.1 147 1.83984e-69 Brachypodium distachyon clone BAC DH003L20, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6344.0 BF_2 12.00 2.93 458 767909407 XP_011507891.1 371 2.8e-33 PREDICTED: discoidin domain-containing receptor 2 isoform X3 [Homo sapiens] 282721095 NG_016290.1 455 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 328 1.1e-29 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-6345.0 BF_2 5.16 0.40 823 642916758 XP_972520.3 441 3.9e-41 PREDICTED: chymotrypsin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SIG2 289 6.7e-25 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-6347.0 BF_2 1.00 4.23 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6351.0 BF_2 2.00 1.38 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6354.0 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6357.0 BF_2 8.00 1.85 468 510865218 EPB80480.1 209 1.8e-14 acyl CoA binding protein [Ancylostoma ceylanicum] 694379079 XM_009367477.1 164 1.35792e-78 PREDICTED: Pyrus x bretschneideri acyl-CoA-binding protein (LOC103955571), mRNA K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 O04066 317 2.2e-28 Acyl-CoA-binding protein OS=Ricinus communis PE=3 SV=1 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-6361.0 BF_2 5.00 0.54 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6362.0 BF_2 5.00 1.24 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6366.0 BF_2 2.00 0.47 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6369.0 BF_2 4.00 0.40 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08272 Topoisomerase I zinc-ribbon-like GO:0006265 DNA topological change GO:0003918//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding GO:0005694 chromosome -- -- Cluster-6371.0 BF_2 4.00 0.54 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6374.0 BF_2 5.00 1.02 493 -- -- -- -- -- 478439721 CP004856.1 488 0 Enterococcus casseliflavus EC20, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6376.0 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6384.0 BF_2 4.00 0.98 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6386.0 BF_2 20.00 0.93 1186 501595209 YP_007890655.1 357 3.1e-31 NADH dehydrogenase subunit 1 (mitochondrion) [Jakoba bahamiensis]>gi|462269359|gb|AGH24149.1| NADH dehydrogenase subunit 1 (mitochondrion) [Jakoba bahamiensis] 528540458 AP012528.1 1171 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 P31839 511 1.8e-50 NADH-ubiquinone oxidoreductase chain 1 OS=Oenothera berteroana GN=ND1 PE=2 SV=1 PF00146//PF03119 NADH dehydrogenase//NAD-dependent DNA ligase C4 zinc finger domain GO:0006281//GO:0055114//GO:0006260 DNA repair//oxidation-reduction process//DNA replication GO:0003911 DNA ligase (NAD+) activity GO:0016020 membrane KOG4770 NADH dehydrogenase subunit 1 Cluster-6387.0 BF_2 3.00 0.92 423 803223415 XP_011971995.1 288 1.1e-23 PREDICTED: splicing factor, proline- and glutamine-rich isoform X2 [Ovis aries musimon]>gi|803223417|ref|XP_011971996.1| PREDICTED: splicing factor, proline- and glutamine-rich isoform X2 [Ovis aries musimon] 767905563 XM_005271115.3 423 0 PREDICTED: Homo sapiens splicing factor proline/glutamine-rich (SFPQ), transcript variant X4, mRNA K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 P23246 288 4.5e-25 Splicing factor, proline- and glutamine-rich OS=Homo sapiens GN=SFPQ PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-6389.0 BF_2 5.00 2.34 374 11466553 NP_044802.1 323 8.5e-28 NADH dehydrogenase subunit 2 (mitochondrion) [Reclinomonas americana]>gi|2258383|gb|AAD11917.1| NADH dehydrogenase subunit 2 (mitochondrion) [Reclinomonas americana] 549067759 AP013107.1 353 0 Aegilops speltoides mitochondrial DNA, complete sequence -- -- -- -- P93401 601 2.0e-61 NADH-ubiquinone oxidoreductase chain 2 OS=Oenothera berteroana GN=ND2 PE=2 SV=2 PF03006 Haemolysin-III related GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane -- -- Cluster-6396.0 BF_2 1.00 0.53 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6401.0 BF_2 10.00 38.55 261 -- -- -- -- -- 347661229 BT131582.1 258 3.96286e-131 Oryza sativa clone RRlibC00308 mRNA sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6402.0 BF_2 3.43 0.53 558 642917240 XP_008191177.1 213 7.2e-15 PREDICTED: uncharacterized protein LOC103312408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-6404.0 BF_2 9.00 0.48 1079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6412.0 BF_2 3.00 0.57 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6413.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6414.0 BF_2 2.00 0.51 452 114052713 NP_001040543.1 666 1.7e-67 proteasome 26S non-ATPase subunit 7 [Bombyx mori]>gi|95103074|gb|ABF51478.1| proteasome 26S non-ATPase subunit 7 [Bombyx mori] -- -- -- -- -- K03038 PSMD7, RPN8 26S proteasome regulatory subunit N8 http://www.genome.jp/dbget-bin/www_bget?ko:K03038 P26270 660 3.5e-68 26S proteasome non-ATPase regulatory subunit 7 OS=Drosophila melanogaster GN=Rpn8 PE=1 SV=6 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding GO:0000502 proteasome complex KOG1556 26S proteasome regulatory complex, subunit RPN8/PSMD7 Cluster-6417.0 BF_2 2.00 0.32 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0007187//GO:0050912//GO:0050909//GO:0007607 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-6420.0 BF_2 55.00 2009.70 204 -- -- -- -- -- 473184 Z29641.1 121 4.30149e-55 Zea mays of USE gene encoding U3snRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6427.0 BF_2 5.00 0.88 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6427.1 BF_2 5.00 0.49 713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6436.0 BF_2 3.00 0.36 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6438.0 BF_2 8.00 1.81 472 -- -- -- -- -- 171906587 NG_007503.1 472 0 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), RefSeqGene on chromosome 17 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6439.0 BF_2 10.00 1.28 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P32292 211 5.6e-16 Indole-3-acetic acid-induced protein ARG2 OS=Vigna radiata var. radiata GN=ARG2 PE=2 SV=1 PF03242 Late embryogenesis abundant protein GO:0006950 response to stress -- -- -- -- -- -- Cluster-6443.0 BF_2 1.00 0.43 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6444.0 BF_2 4.00 0.42 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6445.0 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6446.0 BF_2 1.00 1.74 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6447.0 BF_2 2.00 9.01 256 803153234 XP_011950568.1 305 7.1e-26 PREDICTED: splicing factor U2AF 65 kDa subunit isoform X1 [Ovis aries] 649123892 KJ898405.1 256 5.01386e-130 Synthetic construct Homo sapiens clone ccsbBroadEn_07799 U2AF2 gene, encodes complete protein K12837 U2AF2 splicing factor U2AF 65 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12837 P26368 309 1.0e-27 Splicing factor U2AF 65 kDa subunit OS=Homo sapiens GN=U2AF2 PE=1 SV=4 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0120 Splicing factor U2AF, large subunit (RRM superfamily) Cluster-6448.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6451.0 BF_2 15.00 1.60 679 -- -- -- -- -- 848857625 XM_012974300.1 51 1.31875e-15 PREDICTED: Erythranthe guttatus protein PHLOEM PROTEIN 2-LIKE A9 (LOC105950918), mRNA -- -- -- -- Q9SA16 333 4.4e-30 Protein PHLOEM PROTEIN 2-LIKE A9 OS=Arabidopsis thaliana GN=PP2A9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6456.0 BF_2 11.00 56.39 252 -- -- -- -- -- 670415436 XR_554382.1 252 8.23948e-128 PREDICTED: Zea mays uncharacterized LOC103629430 (LOC103629430), ncRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6458.0 BF_2 1.00 3.23 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6461.0 BF_2 3.00 0.57 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6464.1 BF_2 5.00 0.70 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6465.0 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6470.0 BF_2 2.00 0.32 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6473.0 BF_2 1.00 0.34 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00317 Ribonucleotide reductase, all-alpha domain GO:0055114//GO:0006260//GO:0006206//GO:0006144//GO:0009186 oxidation-reduction process//DNA replication//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0004748//GO:0005524 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//ATP binding GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-6476.0 BF_2 2.00 0.48 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6478.0 BF_2 2.00 2.53 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-6479.0 BF_2 4.00 0.50 623 512981373 XP_004852692.1 564 1.6e-55 PREDICTED: protein S100-A10-like [Heterocephalus glaber] 115298655 NM_002966.2 623 0 Homo sapiens S100 calcium binding protein A10 (S100A10), mRNA K17274 S100A10 calpactin-1 light chain http://www.genome.jp/dbget-bin/www_bget?ko:K17274 P60903 514 4.2e-51 Protein S100-A10 OS=Homo sapiens GN=S100A10 PE=1 SV=2 PF13405//PF00036//PF13833//PF13499 EF-hand domain//EF hand//EF-hand domain pair//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-6482.0 BF_2 1.00 0.46 376 6625746 AAF19378.1 637 3.3e-64 Gq/11 protein alpha subunit [Panulirus argus] 1872547 U89139.1 277 1.63428e-141 HAU89139 Homarus americanus heterotrimeric GTP-binding protein alpha subunit G-alpha-q mRNA, complete cds K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P91950 637 1.4e-65 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homarus americanus PE=2 SV=1 PF00025//PF00503 ADP-ribosylation factor family//G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTP binding -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-6483.0 BF_2 4.00 0.49 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02366 Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0000030 mannosyltransferase activity GO:0000136//GO:0016020 alpha-1,6-mannosyltransferase complex//membrane -- -- Cluster-6486.0 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6496.0 BF_2 9.00 2.34 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6497.0 BF_2 4.00 0.88 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6502.0 BF_2 2.00 0.69 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6505.0 BF_2 2.00 0.36 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6511.0 BF_2 6.00 3.58 353 354505643 XP_003514877.1 341 6.6e-30 PREDICTED: fibroblast growth factor receptor 2 isoform X1 [Cricetulus griseus] 254553324 NG_012449.1 353 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 321 5.6e-29 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-6513.0 BF_2 2.00 0.95 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P0CV94 458 7.8e-45 (3S,6E)-nerolidol synthase 1 OS=Fragaria ananassa PE=1 SV=1 PF03936 Terpene synthase family, metal binding domain -- -- GO:0010333//GO:0016829//GO:0000287 terpene synthase activity//lyase activity//magnesium ion binding -- -- -- -- Cluster-6514.0 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6515.1 BF_2 2.00 2.25 312 557782081 XP_005190656.1 163 2.5e-09 PREDICTED: piggyBac transposable element-derived protein 4-like, partial [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6515.2 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6519.0 BF_2 2.00 3.92 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6520.0 BF_2 33.00 1.05 1599 642938411 XP_008191057.1 1241 1.3e-133 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 O01735 705 7.6e-73 Uncharacterized MFS-type transporter C09D4.1 OS=Caenorhabditis elegans GN=C09D4.1 PE=3 SV=2 PF03137//PF07690 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2563 Permease of the major facilitator superfamily Cluster-6534.0 BF_2 27.00 1.88 889 209876962 XP_002139923.1 679 1.1e-68 40S ribosomal protein S9 [Cryptosporidium muris RN66]>gi|209555529|gb|EEA05574.1| 40S ribosomal protein S9, putative [Cryptosporidium muris RN66] 115450806 NM_001055539.1 860 0 Oryza sativa Japonica Group Os03g0154700 (Os03g0154700) mRNA, complete cds K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 Q9FLF0 848 1.1e-89 40S ribosomal protein S9-2 OS=Arabidopsis thaliana GN=RPS9C PE=2 SV=1 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0019843//GO:0003735 RNA binding//rRNA binding//structural constituent of ribosome GO:0015935//GO:0005622//GO:0005840 small ribosomal subunit//intracellular//ribosome KOG3301 Ribosomal protein S4 Cluster-6535.0 BF_2 1.00 0.33 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6537.0 BF_2 22.00 3.98 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-6541.1 BF_2 40.00 4.11 694 270297190 NP_001161921.1 218 2.4e-15 peritrophic matrix protein 2-C precursor [Tribolium castaneum]>gi|268309036|gb|ACY95484.1| peritrophic matrix protein 2-C [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-6542.0 BF_2 13.00 0.69 1078 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6542.1 BF_2 12.00 1.15 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6544.0 BF_2 4.00 0.74 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6556.0 BF_2 2.00 0.40 498 795204218 XP_011804398.1 218 1.7e-15 PREDICTED: translocation protein SEC62 [Colobus angolensis palliatus]>gi|795204225|ref|XP_011804399.1| PREDICTED: translocation protein SEC62 [Colobus angolensis palliatus] 767927473 XM_011513114.1 498 0 PREDICTED: Homo sapiens SEC62 homolog (S. cerevisiae) (SEC62), transcript variant X1, mRNA K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q99442 218 7.0e-17 Translocation protein SEC62 OS=Homo sapiens GN=SEC62 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6557.0 BF_2 4.00 0.48 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6568.0 BF_2 16.00 1.15 871 644995801 XP_008209259.1 497 1.3e-47 PREDICTED: cathepsin L-like [Nasonia vitripennis] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 456 3.1e-44 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF00112//PF15163 Papain family cysteine protease//Meiosis-expressed GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity GO:0005634 nucleus KOG1543 Cysteine proteinase Cathepsin L Cluster-6569.0 BF_2 2.00 0.75 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6572.0 BF_2 11.00 1.47 601 -- -- -- -- -- 802546848 XM_012231904.1 131 3.9123e-60 PREDICTED: Jatropha curcas zinc finger CCCH domain-containing protein 29 (LOC105646122), mRNA -- -- -- -- Q688R3 268 1.3e-22 Zinc finger CCCH domain-containing protein 33 OS=Oryza sativa subsp. japonica GN=Os05g0128200 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6573.0 BF_2 1.00 0.33 412 642912272 XP_008200632.1 154 3.7e-08 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6573.2 BF_2 5.70 0.36 943 642912272 XP_008200632.1 287 3.2e-23 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M761 161 5.4e-10 Ovochymase-2 OS=Mus musculus GN=Ovch2 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-6574.0 BF_2 2.00 0.47 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6576.0 BF_2 4.00 1.13 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6580.0 BF_2 3.00 1.96 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6587.0 BF_2 5.00 1.27 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6599.0 BF_2 3.00 0.82 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6601.0 BF_2 4.00 0.42 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6604.0 BF_2 8.00 1.39 527 156365547 XP_001626706.1 314 1.3e-26 predicted protein [Nematostella vectensis]>gi|156213593|gb|EDO34606.1| predicted protein [Nematostella vectensis] 347661715 BT132068.1 527 0 Oryza sativa clone RRlibD00873 mRNA sequence K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 Q9M352 438 2.3e-42 60S ribosomal protein L36-2 OS=Arabidopsis thaliana GN=RPL36B PE=2 SV=1 PF01158 Ribosomal protein L36e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0030529//GO:0005622 ribosome//intracellular ribonucleoprotein complex//intracellular KOG3452 60S ribosomal protein L36 Cluster-6606.0 BF_2 2.00 0.32 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6610.0 BF_2 2.00 0.31 554 49574514 NP_000891.2 449 3.1e-42 matrix Gla protein isoform 2 precursor [Homo sapiens]>gi|118572668|sp|P08493.2|MGP_HUMAN RecName: Full=Matrix Gla protein; Short=MGP; AltName: Full=Cell growth-inhibiting gene 36 protein; Flags: Precursor>gi|187591|gb|AAB53765.1| matrix Gla protein [Homo sapiens]>gi|187593|gb|AAB53766.1| matrix Gla protein [Homo sapiens]>gi|46982407|gb|AAT08173.1| GIG36 [Homo sapiens]>gi|62865475|gb|AAY16978.1| matrix Gla protein [Homo sapiens]>gi|119616739|gb|EAW96333.1| matrix Gla protein, isoform CRA_a [Homo sapiens]>gi|119616740|gb|EAW96334.1| matrix Gla protein, isoform CRA_a [Homo sapiens] 299890877 NM_000900.3 554 0 Homo sapiens matrix Gla protein (MGP), transcript variant 2, mRNA K19481 MGP matrix Gla protein http://www.genome.jp/dbget-bin/www_bget?ko:K19481 P08493 449 1.3e-43 Matrix Gla protein OS=Homo sapiens GN=MGP PE=1 SV=2 PF00594 Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain GO:0048754//GO:0030500//GO:0001502//GO:0051592//GO:0009612//GO:0030154//GO:0030324//GO:0009725//GO:0007584 branching morphogenesis of an epithelial tube//regulation of bone mineralization//cartilage condensation//response to calcium ion//response to mechanical stimulus//cell differentiation//lung development//response to hormone//response to nutrient GO:0048306//GO:0005509//GO:0008147//GO:0005201 calcium-dependent protein binding//calcium ion binding//structural constituent of bone//extracellular matrix structural constituent GO:0005578//GO:0005615//GO:0043234//GO:0005576//GO:0005783 proteinaceous extracellular matrix//extracellular space//protein complex//extracellular region//endoplasmic reticulum -- -- Cluster-6615.0 BF_2 1.00 0.66 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6628.0 BF_2 10.00 1.52 563 -- -- -- -- -- 720085001 XM_010245084.1 139 1.30355e-64 PREDICTED: Nelumbo nucifera uncharacterized LOC104587464 (LOC104587464), mRNA -- -- -- -- -- -- -- -- PF13499//PF13405//PF10591//PF13833//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-6635.0 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6637.0 BF_2 23.00 1.39 979 873219822 CEM36796.1 839 3.3e-87 unnamed protein product [Vitrella brassicaformis CCMP3155] 645219577 XM_008238238.1 411 0 PREDICTED: Prunus mume probable mannitol dehydrogenase (LOC103335223), mRNA -- -- -- -- Q9ZRF1 1275 3.7e-139 Probable mannitol dehydrogenase OS=Fragaria ananassa GN=CAD PE=2 SV=1 PF08240//PF02826//PF03446//PF00107//PF13241//PF02737 Alcohol dehydrogenase GroES-like domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Zinc-binding dehydrogenase//Putative NAD(P)-binding//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0006631//GO:0006552//GO:0018874//GO:0006633//GO:0006098//GO:0019354//GO:0019521//GO:0006568//GO:0055114//GO:0006554//GO:0006779//GO:0006550//GO:0006574 fatty acid metabolic process//leucine catabolic process//benzoate metabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//siroheme biosynthetic process//D-gluconate metabolic process//tryptophan metabolic process//oxidation-reduction process//lysine catabolic process//porphyrin-containing compound biosynthetic process//isoleucine catabolic process//valine catabolic process GO:0043115//GO:0051287//GO:0016491//GO:0004616//GO:0003857 precorrin-2 dehydrogenase activity//NAD binding//oxidoreductase activity//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity -- -- -- -- Cluster-6638.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6639.0 BF_2 2.00 0.45 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6642.0 BF_2 2.00 0.37 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6645.0 BF_2 3.00 1.34 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6648.0 BF_2 6.00 0.82 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01776 Ribosomal L22e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-6652.0 BF_2 7.00 1.76 453 556746652 XP_005968790.1 225 2.4e-16 PREDICTED: 2-alkenal reductase (NADP(+)-dependent)-like [Pantholops hodgsonii] -- -- -- -- -- -- -- -- -- Q9SLN8 392 4.2e-37 2-alkenal reductase (NADP(+)-dependent) OS=Nicotiana tabacum GN=DBR PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6654.0 BF_2 1.00 3.05 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6660.0 BF_2 24.00 1.34 1038 556721699 XP_005956696.1 343 1.1e-29 PREDICTED: carbonic anhydrase, chloroplastic-like [Pantholops hodgsonii] 255567324 XM_002524596.1 367 0 Ricinus communis carbonic anhydrase, putative, mRNA -- -- -- -- P27140 1153 5.5e-125 Beta carbonic anhydrase 1, chloroplastic OS=Arabidopsis thaliana GN=BCA1 PE=1 SV=2 PF00484 Carbonic anhydrase GO:0006807//GO:0006730 nitrogen compound metabolic process//one-carbon metabolic process GO:0004089//GO:0008270 carbonate dehydratase activity//zinc ion binding -- -- KOG1578 Predicted carbonic anhydrase involved in protection against oxidative damage Cluster-6662.0 BF_2 5.00 1.43 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6663.0 BF_2 3.00 0.41 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6674.0 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6675.0 BF_2 2.00 0.31 557 820999712 XP_012354849.1 899 2.1e-94 PREDICTED: rab GDP dissociation inhibitor beta isoform X1 [Nomascus leucogenys] 649100166 KJ891233.1 551 0 Synthetic construct Homo sapiens clone ccsbBroadEn_00627 GDI2 gene, encodes complete protein K17255 GDI1_2 Rab GDP dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K17255 P50395 899 8.4e-96 Rab GDP dissociation inhibitor beta OS=Homo sapiens GN=GDI2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1439 RAB proteins geranylgeranyltransferase component A (RAB escort protein) Cluster-6677.0 BF_2 2.28 0.34 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane -- -- Cluster-6678.0 BF_2 3.00 0.36 631 426367917 XP_004050967.1 612 4.4e-61 PREDICTED: CD59 glycoprotein [Gorilla gorilla gorilla] 187829071 NM_203331.2 631 0 Homo sapiens CD59 molecule, complement regulatory protein (CD59), transcript variant 4, mRNA K04008 CD59 CD59 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04008 P13987 632 8.7e-65 CD59 glycoprotein OS=Homo sapiens GN=CD59 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6681.0 BF_2 7.00 0.90 612 -- -- -- -- -- 761231856 KM881642.1 612 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C2Y9 249 2.2e-20 ATP synthase subunit b, chloroplastic OS=Oryza sativa subsp. indica GN=atpF PE=3 SV=1 PF00430 ATP synthase B/B' CF(0) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-6683.1 BF_2 10.00 0.76 839 675379677 KFM72579.1 187 1.1e-11 TSC22 domain family protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q24522 160 6.3e-10 Protein bunched, class 1/class 3/D/E isoforms OS=Drosophila melanogaster GN=bun PE=2 SV=2 PF04799//PF06156//PF01166//PF06005//PF07716 fzo-like conserved region//Protein of unknown function (DUF972)//TSC-22/dip/bun family//Protein of unknown function (DUF904)//Basic region leucine zipper GO:0006260//GO:0006355//GO:0008053//GO:0043093//GO:0000917 DNA replication//regulation of transcription, DNA-templated//mitochondrial fusion//FtsZ-dependent cytokinesis//barrier septum assembly GO:0003924//GO:0043565//GO:0003700 GTPase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667//GO:0005741//GO:0005737 integral component of membrane//transcription factor complex//mitochondrial outer membrane//cytoplasm KOG4797 Transcriptional regulator Cluster-6685.0 BF_2 3.00 0.57 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6686.0 BF_2 4.00 0.58 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6693.0 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6699.0 BF_2 5.00 0.98 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6701.0 BF_2 1.00 1.49 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6707.0 BF_2 2.00 0.31 557 189236361 XP_967894.2 668 1.3e-67 PREDICTED: otopetrin-2 [Tribolium castaneum]>gi|270005442|gb|EFA01890.1| hypothetical protein TcasGA2_TC007500 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6708.0 BF_2 4.00 0.33 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6715.0 BF_2 6.00 2.70 378 799541189 AKA66302.1 519 1.6e-50 heat shock protein 70, partial [Siniperca chuatsi] 799541188 KP121425.1 355 0 Siniperca chuatsi heat shock protein 70 mRNA, partial cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9LHA8 484 7.6e-48 Probable mediator of RNA polymerase II transcription subunit 37c OS=Arabidopsis thaliana GN=MED37C PE=1 SV=1 PF14098 Small, acid-soluble spore protein I GO:0030436 asexual sporulation -- -- -- -- -- -- Cluster-6719.0 BF_2 1.00 0.36 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6722.0 BF_2 3.00 0.45 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6725.0 BF_2 15.00 1.36 747 167384542 XP_001736998.1 186 1.3e-11 hypothetical protein [Entamoeba dispar SAW760]>gi|165900416|gb|EDR26737.1| hypothetical protein, conserved [Entamoeba dispar SAW760] 828312481 XM_004500807.2 172 7.94628e-83 PREDICTED: Cicer arietinum HMG1/2-like protein (LOC101509084), mRNA K11296 HMGB3 high mobility group protein B3 http://www.genome.jp/dbget-bin/www_bget?ko:K11296 P26585 366 7.3e-34 HMG1/2-like protein OS=Glycine max PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6727.0 BF_2 10.00 1.32 605 -- -- -- -- -- 528540458 AP012528.1 605 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6729.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6731.0 BF_2 2.00 0.33 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6733.0 BF_2 5.00 2.10 385 795333225 XP_011928414.1 228 9.1e-17 PREDICTED: guanine nucleotide-binding protein subunit alpha-11 [Cercocebus atys] 583828549 NG_033852.2 254 1.02377e-128 Homo sapiens guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), RefSeqGene on chromosome 19 K04635 GNA11 guanine nucleotide-binding protein subunit alpha-11 http://www.genome.jp/dbget-bin/www_bget?ko:K04635 P45645 222 1.9e-17 Guanine nucleotide-binding protein subunit alpha-11 OS=Meleagris gallopavo GN=GNA11 PE=1 SV=1 PF00503 G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0003924//GO:0031683//GO:0004871//GO:0019001 GTPase activity//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-6736.0 BF_2 13.00 3.31 451 472350607 XP_004394991.1 273 6.5e-22 PREDICTED: ALK tyrosine kinase receptor, partial [Odobenus rosmarus divergens] 221554531 NG_009445.1 451 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 264 2.9e-22 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-6737.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6741.0 BF_2 17.00 1.71 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08133 Anticodon nuclease activator family GO:0050792 regulation of viral process GO:0004518 nuclease activity -- -- -- -- Cluster-6743.0 BF_2 3.00 1.57 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6744.0 BF_2 16.00 1.79 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00802 Pneumovirus attachment glycoprotein G -- -- -- -- GO:0055036 virion membrane -- -- Cluster-6747.0 BF_2 4.00 0.36 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6749.0 BF_2 9.00 0.69 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6750.0 BF_2 2.00 0.66 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6753.0 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6755.0 BF_2 2.00 0.52 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6756.0 BF_2 7.00 1.96 436 640815348 XP_008064439.1 227 1.3e-16 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret [Tarsius syrichta] 336042955 JF276429.1 436 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 205 2.0e-15 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-6757.0 BF_2 1.00 0.38 396 817287400 XP_012313986.1 278 1.5e-22 PREDICTED: histone H1.3 [Aotus nancymaae] 649100440 KJ891320.1 396 0 Synthetic construct Homo sapiens clone ccsbBroadEn_00714 HIST1H1C gene, encodes complete protein K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P16402 278 6.1e-24 Histone H1.3 OS=Homo sapiens GN=HIST1H1D PE=1 SV=2 PF00538 linker histone H1 and H5 family GO:0006334 nucleosome assembly GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-6762.0 BF_2 15.00 87.92 248 -- -- -- -- -- 116310340 CR855194.1 248 1.35357e-125 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSIGBa0134P10, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6763.0 BF_2 15.00 4.60 423 431911952 ELK14096.1 162 4.5e-09 ALK tyrosine kinase receptor [Pteropus alecto] 221554531 NG_009445.1 423 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 157 7.1e-10 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-6764.0 BF_2 2.00 0.31 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6771.0 BF_2 3.00 0.92 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6772.0 BF_2 6.00 0.63 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6779.0 BF_2 9.00 1.34 568 -- -- -- -- -- 115466321 NM_001063295.1 411 0 Oryza sativa Japonica Group Os06g0141400 (Os06g0141400) mRNA, partial cds -- -- -- -- Q02921 202 5.7e-15 Early nodulin-93 OS=Glycine max PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6780.0 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6783.0 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6789.0 BF_2 26.00 3.68 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13202//PF13499//PF13833//PF10591//PF13405//PF00036 EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-6795.0 BF_2 9.00 2.10 466 470486464 XP_004344608.1 166 1.7e-09 60s Acidic ribosomal protein [Acanthamoeba castellanii str. Neff]>gi|440799822|gb|ELR20865.1| 60s Acidic ribosomal protein [Acanthamoeba castellanii str. Neff] 116641618 CT830585.1 457 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCSN022M13, full insert sequence K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P46252 260 8.8e-22 60S acidic ribosomal protein P2A OS=Zea mays GN=RPP2A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-6798.0 BF_2 2.00 0.36 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6805.0 BF_2 5.00 0.52 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6809.0 BF_2 2.00 0.35 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6810.0 BF_2 12.00 1.53 616 545220855 XP_005611522.1 294 3.2e-24 PREDICTED: guanine nucleotide-binding protein subunit alpha-11 isoform X2 [Equus caballus] 157841359 AC206587.3 613 0 Homo sapiens FOSMID clone ABC9-41277500N5 from chromosome 19, complete sequence K04635 GNA11 guanine nucleotide-binding protein subunit alpha-11 http://www.genome.jp/dbget-bin/www_bget?ko:K04635 P29992 276 1.6e-23 Guanine nucleotide-binding protein subunit alpha-11 OS=Homo sapiens GN=GNA11 PE=1 SV=2 PF00503//PF05433//PF00025 G-protein alpha subunit//Glycine zipper 2TM domain//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0031683//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0019867 outer membrane KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-6814.0 BF_2 1.00 2.96 270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6815.0 BF_2 2.00 0.36 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6816.0 BF_2 5.00 1.44 432 -- -- -- -- -- 645244659 XR_513816.1 136 4.57586e-63 PREDICTED: Prunus mume uncharacterized LOC103327926 (LOC103327926), ncRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6823.0 BF_2 3.00 0.82 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6824.0 BF_2 1.00 1.49 298 529161415 AGS56987.1 474 2.1e-45 calmodulin [Meretrix meretrix] 60729720 AJ843113.1 238 6.04308e-120 Quercus petraea mRNA for calmodulin (caM-3 gene) K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P93087 512 3.4e-51 Calmodulin OS=Capsicum annuum GN=CCM1 PE=2 SV=3 PF13202//PF00036//PF02563//PF12763//PF13499//PF10591//PF13833//PF13405 EF hand//EF hand//Polysaccharide biosynthesis/export protein//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0015774//GO:0007165 polysaccharide transport//signal transduction GO:0015159//GO:0005515//GO:0005509 polysaccharide transmembrane transporter activity//protein binding//calcium ion binding GO:0005578//GO:0016020 proteinaceous extracellular matrix//membrane KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-6829.0 BF_2 3.00 0.60 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6831.0 BF_2 2.00 0.45 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6833.0 BF_2 3.00 0.31 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6834.0 BF_2 4.00 1.01 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6837.0 BF_2 39.00 4.86 623 -- -- -- -- -- 63056242 AY961622.1 590 0 Oryza sativa (indica cultivar-group) cultivar APMS-6A clone 1 ATP8 (atp8) mRNA, complete cds; mitochondrial -- -- -- -- P43650 609 4.0e-62 Putative ATP synthase protein YMF19 OS=Triticum aestivum GN=YMF19 PE=2 SV=1 PF00895//PF06449 ATP synthase protein 8//Mitochondrial domain of unknown function (DUF1082) GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078//GO:0016820 hydrogen ion transmembrane transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016021//GO:0000276//GO:0005739 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//mitochondrion -- -- Cluster-6838.0 BF_2 3.00 0.87 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6847.0 BF_2 4.00 0.57 579 270017034 EFA13480.1 136 6.4e-06 hypothetical protein TcasGA2_TC002031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6850.0 BF_2 2.00 0.40 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6852.0 BF_2 4.00 1.52 396 -- -- -- -- -- 820703208 LN847501.1 396 0 TPA: Homo sapiens SCARNA2 gene for small nucleolar RNA SCARNA2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6860.0 BF_2 3.00 1.02 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6864.0 BF_2 11.00 14.19 305 -- -- -- -- -- 528533069 AB809163.1 160 1.42083e-76 Porostereum crassum genes for 18S rRNA, ITS1, 5.8S rRNA, ITS2, 28S rRNA, IGS1, 5S rRNA, partial and complete sequence, strain: MAFF 420737 -- -- -- -- -- -- -- -- PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase GO:0051191 prosthetic group biosynthetic process -- -- -- -- -- -- Cluster-6865.0 BF_2 27.00 243.34 236 -- -- -- -- -- 15623895 AP003328.3 223 1.01446e-111 Oryza sativa Japonica Group genomic DNA, chromosome 1, BAC clone:B1040D09 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6867.0 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6870.0 BF_2 1.00 2.39 278 32363273 Q23755.1 169 4.5e-10 RecName: Full=Pigment-dispersing hormone 1 peptides; Contains: RecName: Full=PDH precursor-related peptide 1; Contains: RecName: Full=Pigment-dispersing hormone 1; Short=PDH 1; Flags: Precursor [Callinectes sapidus]>gi|609438|gb|AAA67052.1| pigment-dispersing hormone I [Callinectes sapidus] 598089 L36716.1 211 5.70684e-105 CLLPDHI Callinectes sapidus pigment dispersing hormone I (PDH1) mRNA, complete cds -- -- -- -- Q23755 169 1.9e-11 Pigment-dispersing hormone 1 peptides OS=Callinectes sapidus GN=PDH1 PE=2 SV=1 PF06324 Pigment-dispersing hormone (PDH) GO:0007165//GO:0009416 signal transduction//response to light stimulus GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-6872.0 BF_2 5.00 1.82 401 847013788 XP_012804286.1 297 9.4e-25 PREDICTED: LOW QUALITY PROTEIN: platelet-derived growth factor receptor alpha [Jaculus jaculus] 219521916 NG_009250.1 398 0 Homo sapiens platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), RefSeqGene (LRG_309) on chromosome 4 K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 P16234 294 8.6e-26 Platelet-derived growth factor receptor alpha OS=Homo sapiens GN=PDGFRA PE=1 SV=1 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-6873.0 BF_2 3.00 1.09 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6877.0 BF_2 8.00 0.93 646 871263835 XP_005108725.2 188 6.6e-12 PREDICTED: uncharacterized protein C167.05-like [Aplysia californica] 720043399 XM_010271246.1 182 1.88303e-88 PREDICTED: Nelumbo nucifera universal stress protein A-like protein (LOC104606168), transcript variant X2, mRNA -- -- -- -- Q57951 144 3.5e-08 Universal stress protein MJ0531 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=MJ0531 PE=3 SV=1 PF02789//PF00582 Cytosol aminopeptidase family, N-terminal domain//Universal stress protein family GO:0006950//GO:0006508 response to stress//proteolysis GO:0004177 aminopeptidase activity GO:0005622 intracellular -- -- Cluster-6884.0 BF_2 3.00 8.19 273 -- -- -- -- -- 7768705 AP001697.1 209 7.23161e-104 Homo sapiens genomic DNA, chromosome 21q, section 41/105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6886.0 BF_2 2.00 0.55 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6887.0 BF_2 8.00 0.86 677 470455141 XP_004340915.1 626 1.1e-62 UDPglucose pyrophosphorylase 2 isoform, putative [Acanthamoeba castellanii str. Neff]>gi|440797781|gb|ELR18856.1| UDPglucose pyrophosphorylase 2 isoform, putative [Acanthamoeba castellanii str. Neff] 701448693 KJ909976.1 671 0 Oryza sativa Japonica Group clone KCG117C07 UDP-glucose pyrophospholase mRNA, complete cds K00963 UGP2, galU, galF UTP--glucose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00963 Q43772 1022 5.6e-110 UTP--glucose-1-phosphate uridylyltransferase OS=Hordeum vulgare PE=2 SV=1 PF01704 UTP--glucose-1-phosphate uridylyltransferase GO:0008152 metabolic process GO:0070569 uridylyltransferase activity -- -- KOG2638 UDP-glucose pyrophosphorylase Cluster-6890.0 BF_2 2.00 1.60 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6892.0 BF_2 4.00 0.74 513 -- -- -- -- -- 596287033 XM_007225650.1 266 2.97233e-135 Prunus persica hypothetical protein (PRUPE_ppa004224mg) mRNA, complete cds -- -- -- -- Q940H8 724 1.5e-75 FRIGIDA-like protein 4b OS=Arabidopsis thaliana GN=FRL4B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6896.0 BF_2 3.00 0.31 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-690.1 BF_2 3.00 0.36 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6906.0 BF_2 2.00 0.31 558 -- -- -- -- -- 690556314 LN111934.1 57 4.94941e-19 Spirometra erinaceieuropaei genome assembly S_erinaceieuropaei ,scaffold SPER_scaffold0105141 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6907.0 BF_2 4.00 2.30 356 1353726 AAB01769.1 333 5.6e-29 cysteine proteinase homolog, partial [Naegleria fowleri] 645229150 XM_008223107.1 214 1.61712e-106 PREDICTED: Prunus mume cysteine proteinase 15A-like (LOC103321308), mRNA K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 P43295 538 3.9e-54 Probable cysteine proteinase A494 OS=Arabidopsis thaliana GN=At2g21430 PE=2 SV=2 PF00112 Papain family cysteine protease GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- -- -- Cluster-6907.1 BF_2 2.00 0.63 419 815805576 XP_012223533.1 283 4.1e-23 PREDICTED: uncharacterized protein LOC105672877 [Linepithema humile] 638110956 LK022694.1 201 3.25677e-99 Fagus sylvatica partial cyspro gene for Cysteine proteinase, exons 1-2 K01373 CTSF cathepsin F http://www.genome.jp/dbget-bin/www_bget?ko:K01373 P05993 466 1.0e-45 Cysteine proteinase (Fragment) OS=Carica papaya PE=2 SV=1 PF03051//PF00112//PF02100 Peptidase C1-like family//Papain family cysteine protease//Ornithine decarboxylase antizyme GO:0019467//GO:0006508 ornithine catabolic process, by decarboxylation//proteolysis GO:0004857//GO:0004197//GO:0008073//GO:0008234 enzyme inhibitor activity//cysteine-type endopeptidase activity//ornithine decarboxylase inhibitor activity//cysteine-type peptidase activity -- -- KOG1542 Cysteine proteinase Cathepsin F Cluster-6909.0 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6916.0 BF_2 8.00 1.11 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6917.0 BF_2 5.00 1.33 444 -- -- -- -- -- 349713059 FQ386445.1 84 3.80174e-34 Vitis vinifera clone SS0AEB29YO21 -- -- -- -- -- -- -- -- PF00257//PF04931 Dehydrin//DNA polymerase phi GO:0009415//GO:0006260//GO:0006950//GO:0006351 response to water//DNA replication//response to stress//transcription, DNA-templated GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex -- -- Cluster-6918.0 BF_2 5.00 0.64 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6921.0 BF_2 2.00 0.34 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6923.0 BF_2 3.00 1.28 383 820145772 KKX13551.1 548 7.1e-54 eukaryotic translation elongation factor 2b [Scleropages formosus] 743938151 XM_011015191.1 260 4.70271e-132 PREDICTED: Populus euphratica elongation factor 2 (LOC105117505), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 O23755 647 9.6e-67 Elongation factor 2 OS=Beta vulgaris PE=2 SV=1 PF03764 Elongation factor G, domain IV -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-6925.0 BF_2 6.00 0.74 627 642921121 XP_008192696.1 237 1.3e-17 PREDICTED: H2.0-like homeobox protein [Tribolium castaneum]>gi|270006199|gb|EFA02647.1| hypothetical protein TcasGA2_TC008368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6925.1 BF_2 1.00 0.32 418 642921121 XP_008192696.1 478 1.0e-45 PREDICTED: H2.0-like homeobox protein [Tribolium castaneum]>gi|270006199|gb|EFA02647.1| hypothetical protein TcasGA2_TC008368 [Tribolium castaneum] 768941240 XM_011612188.1 62 6.04414e-22 PREDICTED: Takifugu rubripes H2.0-like homeobox (hlx), transcript variant X2, mRNA K09339 HLX1 homeobox protein HLX1 http://www.genome.jp/dbget-bin/www_bget?ko:K09339 Q14774 324 3.0e-29 H2.0-like homeobox protein OS=Homo sapiens GN=HLX PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0000976//GO:0003700//GO:0003677 transcription regulatory region sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0491 Transcription factor BSH, contains HOX domain Cluster-6926.0 BF_2 12.00 2.06 531 470456529 XP_004341067.1 406 2.9e-37 peptidylprolyl cis-trans isomerase, cyclophilin-type, putative [Acanthamoeba castellanii str. Neff]>gi|440797929|gb|ELR19003.1| peptidylprolyl cis-trans isomerase, cyclophilin-type, putative [Acanthamoeba castellanii str. Neff] 347660115 BT130468.1 531 0 Oryza sativa clone RRlibC01173 mRNA sequence K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 Q8LDP4 470 4.5e-46 Peptidyl-prolyl cis-trans isomerase CYP19-4 OS=Arabidopsis thaliana GN=CYP19-4 PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- -- -- Cluster-6933.0 BF_2 3.00 2.04 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6935.0 BF_2 3.00 0.42 587 391346848 XP_003747680.1 362 4.0e-32 PREDICTED: succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial-like [Metaseiulus occidentalis] -- -- -- -- -- K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q96I99 271 5.9e-23 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens GN=SUCLG2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-6938.0 BF_2 2.00 0.45 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6939.0 BF_2 2.00 0.82 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6940.0 BF_2 25.95 2.59 706 159492355 ABW97364.1 354 4.1e-31 chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit 2 [Amorphochlora amoebiformis] 1536888 Y07779.1 366 0 Betula pendula mRNA for ribulose-1,5-bisphosphate carboxylase (rbcS gene) -- -- -- -- Q96542 782 4.0e-82 Ribulose bisphosphate carboxylase small chain, chloroplastic OS=Betula pendula GN=RBCS1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-6941.0 BF_2 10.00 1.43 580 873237682 CEL97078.1 239 7.3e-18 unnamed protein product [Vitrella brassicaformis CCMP3155] 702243573 XM_010051864.1 120 4.90803e-54 PREDICTED: Eucalyptus grandis germin-like protein subfamily 1 member 7 (LOC104438677), mRNA -- -- -- -- Q9SFF9 641 7.3e-66 Germin-like protein subfamily 1 member 7 OS=Arabidopsis thaliana GN=At3g05950 PE=2 SV=1 PF00190 Cupin -- -- GO:0045735 nutrient reservoir activity -- -- -- -- Cluster-6947.0 BF_2 3.00 0.74 456 -- -- -- -- -- 528540458 AP012528.1 449 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P46773 674 8.5e-70 Ribosomal protein S3, mitochondrial OS=Oryza sativa subsp. japonica GN=RPS3 PE=3 SV=1 PF07229 VirE2 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-6951.0 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6968.0 BF_2 17.00 1.38 803 530564900 XP_005279021.1 263 1.7e-20 PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Chrysemys picta bellii]>gi|641771455|ref|XP_008169774.1| PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Chrysemys picta bellii] 115444900 NM_001052765.1 797 0 Oryza sativa Japonica Group Os02g0202400 (Os02g0202400) mRNA, complete cds K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 P29518 576 3.5e-58 Adenine nucleotide transporter BT1, chloroplastic/amyloplastic/mitochondrial OS=Zea mays GN=BT1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0752 Mitochondrial solute carrier protein Cluster-6969.0 BF_2 5.00 0.34 905 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6974.0 BF_2 5.00 1.57 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6975.0 BF_2 2.00 0.50 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6977.0 BF_2 6.00 1.64 440 670996654 XP_008689196.1 538 1.2e-52 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha [Ursus maritimus] 31745472 AC145214.1 327 3.11014e-169 Homo sapiens fosmid clone XXFOS-82587F5 from 2, complete sequence K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P50148 516 1.7e-51 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homo sapiens GN=GNAQ PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-6981.0 BF_2 11.00 0.50 1214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6986.0 BF_2 11.00 0.76 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6989.0 BF_2 36.42 0.52 3210 297595484 ADI48183.1 952 8.5e-100 membrane alanyl aminopeptidase 3 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P15684 617 2.4e-62 Aminopeptidase N OS=Rattus norvegicus GN=Anpep PE=1 SV=2 PF00342//PF01433 Phosphoglucose isomerase//Peptidase family M1 GO:0006096//GO:0005982//GO:0006098//GO:0005985//GO:0006094 glycolytic process//starch metabolic process//pentose-phosphate shunt//sucrose metabolic process//gluconeogenesis GO:0008270//GO:0008237//GO:0004347 zinc ion binding//metallopeptidase activity//glucose-6-phosphate isomerase activity -- -- -- -- Cluster-6990.0 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6991.0 BF_2 7.00 3.18 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6992.0 BF_2 10.00 2.98 427 441665919 XP_004093233.1 268 2.3e-21 PREDICTED: LOW QUALITY PROTEIN: GTPase HRas [Nomascus leucogenys] 187960074 NG_007666.1 427 0 Homo sapiens Harvey rat sarcoma viral oncogene homolog (HRAS), RefSeqGene on chromosome 11 K02833 HRAS GTPase HRas http://www.genome.jp/dbget-bin/www_bget?ko:K02833 P01112 241 1.3e-19 GTPase HRas OS=Homo sapiens GN=HRAS PE=1 SV=1 PF03193//PF00071//PF02421 Protein of unknown function, DUF258//Ras family//Ferrous iron transport protein B GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0015093//GO:0003924 GTP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0395 Ras-related GTPase Cluster-6995.0 BF_2 7.10 0.55 829 66808541 XP_637993.1 492 4.8e-47 alanine transaminase [Dictyostelium discoideum AX4]>gi|74853641|sp|Q54MJ7.1|ALAM_DICDI RecName: Full=Probable alanine aminotransferase, mitochondrial; Short=ALT; AltName: Full=Glutamate pyruvate transaminase; Short=GPT; AltName: Full=Glutamic--alanine transaminase; AltName: Full=Glutamic--pyruvic transaminase; Flags: Precursor>gi|60466429|gb|EAL64484.1| alanine transaminase [Dictyostelium discoideum AX4] 169244420 EU267962.1 764 0 Oryza sativa Japonica Group clone KCS222H02 alanine aminotransferase mRNA, complete cds K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 P34106 779 1.0e-81 Alanine aminotransferase 2 OS=Panicum miliaceum PE=1 SV=1 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0258 Alanine aminotransferase Cluster-6995.1 BF_2 43.90 1.27 1733 831772779 XP_012753709.1 1289 3.8e-139 hypothetical protein SAMD00019534_064350 [Acytostelium subglobosum LB1]>gi|735854341|dbj|GAM23260.1| hypothetical protein SAMD00019534_064350 [Acytostelium subglobosum LB1] 115481821 NM_001071039.1 1729 0 Oryza sativa Japonica Group Os10g0390500 (Os10g0390500) mRNA, complete cds K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 P34106 2138 5.6e-239 Alanine aminotransferase 2 OS=Panicum miliaceum PE=1 SV=1 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0258 Alanine aminotransferase Cluster-6996.0 BF_2 5.00 0.50 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-6999.0 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7002.0 BF_2 3.00 0.47 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7006.0 BF_2 6.00 2.00 412 859847305 XP_012918154.1 227 1.3e-16 PREDICTED: mast/stem cell growth factor receptor Kit isoform X4 [Mustela putorius furo] 170014706 NG_007456.1 412 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P43481 187 2.3e-13 Mast/stem cell growth factor receptor Kit OS=Bos taurus GN=KIT PE=2 SV=1 PF03661//PF07714//PF00069 Uncharacterised protein family (UPF0121)//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016021 integral component of membrane -- -- Cluster-7007.0 BF_2 13.00 1.60 626 514689446 XP_004992298.1 516 6.0e-50 alanine aminotransferase [Salpingoeca rosetta]>gi|326429675|gb|EGD75245.1| alanine aminotransferase [Salpingoeca rosetta] 743940395 XM_011016368.1 385 0 PREDICTED: Populus euphratica glutamate--glyoxylate aminotransferase 2 (LOC105118417), transcript variant X2, mRNA K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q9S7E9 854 1.6e-90 Glutamate--glyoxylate aminotransferase 2 OS=Arabidopsis thaliana GN=GGAT2 PE=1 SV=1 PF15191 Synaptonemal complex central element protein 3 GO:0007283//GO:0007130//GO:0007131 spermatogenesis//synaptonemal complex assembly//reciprocal meiotic recombination GO:0016740 transferase activity -- -- KOG0258 Alanine aminotransferase Cluster-7008.0 BF_2 11.00 1.05 724 569386409 ETO16925.1 711 1.7e-72 hypothetical protein RFI_20413 [Reticulomyxa filosa] 595840686 XM_007208004.1 384 0 Prunus persica hypothetical protein (PRUPE_ppa001833mg) mRNA, complete cds -- -- -- -- P31414 927 6.2e-99 Pyrophosphate-energized vacuolar membrane proton pump 1 OS=Arabidopsis thaliana GN=AVP1 PE=1 SV=1 PF03030 Inorganic H+ pyrophosphatase GO:0015992//GO:0006119 proton transport//oxidative phosphorylation GO:0009678//GO:0004427 hydrogen-translocating pyrophosphatase activity//inorganic diphosphatase activity GO:0016020 membrane -- -- Cluster-7010.0 BF_2 3.00 2.04 343 803207736 XP_011964399.1 432 1.8e-40 PREDICTED: 40S ribosomal protein S21 isoform X3 [Ovis aries musimon] 115553416 AK236619.1 343 3.02131e-178 Sus scrofa mRNA, clone:OVRM10208G12, expressed in ovary K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 P63221 424 6.2e-41 40S ribosomal protein S21 OS=Sus scrofa GN=RPS21 PE=1 SV=1 PF01249 Ribosomal protein S21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3486 40S ribosomal protein S21 Cluster-7018.0 BF_2 12.00 6.27 364 640783259 XP_008047301.1 412 4.0e-38 PREDICTED: discoidin domain-containing receptor 2-like [Tarsius syrichta] 282721095 NG_016290.1 361 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 396 1.2e-37 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-7019.1 BF_2 11.00 0.59 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7020.0 BF_2 2.00 0.53 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7022.0 BF_2 10.00 1.47 572 700589138 AIU94830.1 428 8.7e-40 60S ribosomal protein [Phragmatopoma lapidosa] 150172072 CU406489.1 569 0 Oryza rufipogon (W1943) cDNA clone: ORW1943C003B08, full insert sequence K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q96499 505 4.2e-50 60S ribosomal protein L44 OS=Gossypium hirsutum GN=RPL44 PE=3 SV=3 PF00924//PF14876//PF00935 Mechanosensitive ion channel//Respiratory growth transcriptional regulator//Ribosomal protein L44 GO:0042254//GO:0006412//GO:0045333//GO:0055085 ribosome biogenesis//translation//cellular respiration//transmembrane transport GO:0003735 structural constituent of ribosome GO:0005739//GO:0005622//GO:0016020//GO:0005840//GO:0005634 mitochondrion//intracellular//membrane//ribosome//nucleus KOG3464 60S ribosomal protein L44 Cluster-7023.0 BF_2 9.00 1.35 566 -- -- -- -- -- 119710194 DQ490951.2 563 0 Zea mays subsp. mays genotype CMS-S mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7028.0 BF_2 6.00 2.97 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7028.1 BF_2 3.00 0.46 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7031.0 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7033.0 BF_2 9.00 1.05 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7036.0 BF_2 9.00 0.61 909 553832072 AGY61441.1 379 6.6e-34 50S ribosomal protein L14 [Lotharella sp. CCMP622] 32990517 AK105308.1 909 0 Oryza sativa Japonica Group cDNA clone:001-117-B12, full insert sequence K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 Q6END7 611 3.4e-62 50S ribosomal protein L14, chloroplastic OS=Oryza nivara GN=rpl14 PE=3 SV=1 PF00238//PF00410 Ribosomal protein L14p/L23e//Ribosomal protein S8 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-7039.0 BF_2 23.00 4.56 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7040.0 BF_2 2.00 1.42 340 699631985 XP_009892680.1 460 1.0e-43 PREDICTED: histone H4-like [Charadrius vociferus] 347661404 BT131757.1 328 6.52269e-170 Oryza sativa clone RRlibB00013 mRNA sequence K11254 H4 histone H4 http://www.genome.jp/dbget-bin/www_bget?ko:K11254 P0CG89 454 2.0e-44 Histone H4 OS=Glycine max PE=3 SV=1 PF02969//PF02291//PF00125 TATA box binding protein associated factor (TAF)//Transcription initiation factor IID, 31kD subunit//Core histone H2A/H2B/H3/H4 GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding GO:0005634 nucleus KOG3467 Histone H4 Cluster-7052.0 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7056.0 BF_2 5.00 142.43 209 -- -- -- -- -- 767889587 XR_958126.1 209 5.33499e-104 PREDICTED: Homo sapiens monofunctional C1-tetrahydrofolate synthase, mitochondrial-like (LOC101928195), transcript variant X13, misc_RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7058.0 BF_2 11.00 1.48 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7060.0 BF_2 7.08 1.10 555 15420657 AAK97411.1 194 1.2e-12 serine protease-like protein [Anthonomus grandis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00523//PF00089 Fusion glycoprotein F0//Trypsin GO:0006948//GO:0006508 induction by virus of host cell-cell fusion//proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-7065.0 BF_2 4.00 0.38 732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7067.0 BF_2 8.00 0.52 927 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7069.0 BF_2 12.00 6.13 366 194318432 ACF47604.1 362 2.5e-32 soluble MET variant 2 [Homo sapiens] 212720875 NG_008996.1 366 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2QLF1 177 2.9e-12 Hepatocyte growth factor receptor OS=Pan troglodytes GN=MET PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7071.0 BF_2 39.00 1.60 1309 -- -- -- -- -- 645235010 XM_008225854.1 211 2.9657e-104 PREDICTED: Prunus mume uncharacterized LOC103323832 (LOC103323832), mRNA -- -- -- -- Q9SS87 509 3.3e-50 Protein SIEVE ELEMENT OCCLUSION B OS=Arabidopsis thaliana GN=SEOB PE=1 SV=1 PF04856 Securin sister-chromatid separation inhibitor GO:0051276 chromosome organization -- -- GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-7085.1 BF_2 3.00 0.66 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7086.0 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7088.0 BF_2 4.00 1.29 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7092.0 BF_2 5.00 1.53 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7093.0 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7096.0 BF_2 14.00 5.82 386 -- -- -- -- -- 219888684 BT056110.1 372 0 Zea mays full-length cDNA clone ZM_BFb0020N13 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7101.0 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7104.0 BF_2 1.00 0.77 335 -- -- -- -- -- 758198082 XM_011323110.1 335 8.2417e-174 Fusarium graminearum PH-1 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7107.0 BF_2 8.00 1.17 572 -- -- -- -- -- 571548558 XM_006602758.1 58 1.41289e-19 PREDICTED: Glycine max protein BPS1, chloroplastic-like (LOC100816751), transcript variant X3, mRNA -- -- -- -- Q9LMM6 221 3.6e-17 Protein BPS1, chloroplastic OS=Arabidopsis thaliana GN=BPS1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7117.0 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7119.0 BF_2 4.00 1.24 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7123.0 BF_2 3.00 0.65 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7127.0 BF_2 10.00 4.89 370 795474161 XP_011768541.1 295 1.5e-24 PREDICTED: discoidin domain-containing receptor 2 isoform X1 [Macaca nemestrina] 282721095 NG_016290.1 370 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 295 6.1e-26 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-7129.0 BF_2 12.00 1.96 543 462269716 AGH24377.1 508 4.4e-49 NADH dehydrogenase subunit 5 (mitochondrion) [Reclinomonas americana ATCC 50283] 528540458 AP012528.1 389 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- Q37680 649 8.1e-67 NADH-ubiquinone oxidoreductase chain 5 OS=Triticum aestivum GN=ND5 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7133.0 BF_2 7.00 2.42 407 119620912 EAX00507.1 176 1.0e-10 anaplastic lymphoma kinase (Ki-1), isoform CRA_b [Homo sapiens] 221554531 NG_009445.1 401 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 172 1.2e-11 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-7134.0 BF_2 2.00 0.35 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04355 SmpA / OmlA family -- -- -- -- GO:0019867 outer membrane -- -- Cluster-7135.0 BF_2 11.00 0.94 778 -- -- -- -- -- 119395213 EF122481.1 775 0 Oryza sativa (japonica cultivar-group) clone KCS342H03 sucrose synthase 2 mRNA, complete cds -- -- -- -- P30298 1145 3.5e-124 Sucrose synthase 2 OS=Oryza sativa subsp. japonica GN=SUS2 PE=1 SV=2 PF00862 Sucrose synthase GO:0005982//GO:0005985 starch metabolic process//sucrose metabolic process GO:0016157 sucrose synthase activity -- -- -- -- Cluster-7138.1 BF_2 4.00 0.31 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7140.0 BF_2 3.00 0.53 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7142.0 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7144.0 BF_2 13.00 1.51 647 -- -- -- -- -- 119710194 DQ490951.2 589 0 Zea mays subsp. mays genotype CMS-S mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7149.0 BF_2 4.00 0.32 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-7158.0 BF_2 6.00 0.33 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7160.0 BF_2 1.00 0.40 390 685615894 XP_009195712.1 578 2.4e-57 PREDICTED: 60S ribosomal protein L36a-like [Papio anubis] 453040294 NM_001001.4 339 5.82224e-176 Homo sapiens ribosomal protein L36a-like (RPL36AL), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 P83882 563 5.4e-57 60S ribosomal protein L36a OS=Mus musculus GN=Rpl36a PE=1 SV=2 PF00935 Ribosomal protein L44 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3464 60S ribosomal protein L44 Cluster-7161.0 BF_2 6.00 1.66 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7166.0 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7168.0 BF_2 30.00 3.48 648 -- -- -- -- -- 156764688 AK288073.1 633 0 Oryza sativa Japonica Group cDNA, clone: J075161O09, full insert sequence -- -- -- -- P01088 169 4.4e-11 Trypsin/factor XIIA inhibitor OS=Zea mays PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-7171.1 BF_2 1.46 1.12 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7181.0 BF_2 12.00 0.82 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9SSA8 229 6.7e-18 Ethylene-responsive transcription factor RAP2-12 OS=Arabidopsis thaliana GN=RAP2-12 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7182.0 BF_2 2.00 0.37 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7185.0 BF_2 3.00 2.40 332 823460029 XP_012428949.1 258 2.6e-20 PREDICTED: platelet-derived growth factor receptor alpha [Taeniopygia guttata] 60391308 D50017.2 332 3.7964e-172 Homo sapiens PDGFRA gene for alpha-platelet-derived growth factor receptor, complete cds K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 P26619 258 1.1e-21 Platelet-derived growth factor receptor alpha OS=Xenopus laevis GN=pdgfra PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7187.0 BF_2 8.00 0.33 1295 546678835 ERL89380.1 1052 8.7e-112 hypothetical protein D910_06751, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4MYA4 436 9.6e-42 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-7188.1 BF_2 10.90 0.45 1294 91088603 XP_973741.1 1036 6.2e-110 PREDICTED: sodium-dependent nutrient amino acid transporter 1 [Tribolium castaneum]>gi|642931940|ref|XP_008196786.1| PREDICTED: sodium-dependent nutrient amino acid transporter 1 [Tribolium castaneum]>gi|270012259|gb|EFA08707.1| hypothetical protein TcasGA2_TC006378 [Tribolium castaneum] 602654660 XM_007433088.1 38 4.33664e-08 PREDICTED: Python bivittatus solute carrier family 6 (neurotransmitter transporter), member 2 (SLC6A2), mRNA K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 B4MEG2 791 6.6e-83 Sodium-dependent nutrient amino acid transporter 1 OS=Drosophila virilis GN=NAAT1 PE=3 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-7190.0 BF_2 9.00 1.37 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7192.0 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7194.0 BF_2 6.00 0.71 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7195.0 BF_2 6.00 2.15 403 537204388 ERE79693.1 233 2.5e-17 GTPase HRas-like protein [Cricetulus griseus] 187960074 NG_007666.1 403 0 Homo sapiens Harvey rat sarcoma viral oncogene homolog (HRAS), RefSeqGene on chromosome 11 K02833 HRAS GTPase HRas http://www.genome.jp/dbget-bin/www_bget?ko:K02833 P01115 214 1.6e-16 Transforming protein p29 OS=Harvey murine sarcoma virus GN=H-RAS PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7196.0 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7197.0 BF_2 9.00 2.59 432 294887493 XP_002772137.1 148 1.9e-07 vacuolar ATP synthase 16 kDa proteolipid subunit, putative [Perkinsus marinus ATCC 50983]>gi|239876075|gb|EER03953.1| vacuolar ATP synthase 16 kDa proteolipid subunit, putative [Perkinsus marinus ATCC 50983] 828323715 XM_004507454.2 156 3.48766e-74 PREDICTED: Cicer arietinum V-type proton ATPase 16 kDa proteolipid subunit (LOC101498538), mRNA -- -- -- -- Q43434 196 2.1e-14 V-type proton ATPase 16 kDa proteolipid subunit OS=Gossypium hirsutum GN=CVA16-2 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991//GO:0006811 proton transport//ATP hydrolysis coupled proton transport//ion transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177//GO:0044425 proton-transporting two-sector ATPase complex, proton-transporting domain//membrane part KOG0232 Vacuolar H+-ATPase V0 sector, subunits c/c' Cluster-7200.1 BF_2 2.00 0.46 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7202.0 BF_2 5.00 0.56 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7204.0 BF_2 2.71 1.16 383 119607362 EAW86956.1 477 1.2e-45 hCG1983635 [Homo sapiens] 151933346 AC201954.2 317 9.68774e-164 Pan troglodytes chromosome X clone CH251-51M1 map human ortholog p11.3, complete sequence -- -- -- -- O00370 403 1.9e-38 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7206.0 BF_2 19.00 1.20 949 -- -- -- -- -- 590643008 XM_007030621.1 44 1.45648e-11 Theobroma cacao Uncharacterized protein (TCM_026440) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7209.0 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7211.0 BF_2 5.00 1.59 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7215.0 BF_2 3.00 0.33 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7219.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7222.0 BF_2 4.00 0.36 756 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05964 F/Y-rich N-terminus -- -- -- -- GO:0005634 nucleus -- -- Cluster-7224.0 BF_2 13.00 1.05 804 -- -- -- -- -- 448279784 JX046831.1 84 7.12025e-34 Callerya speciosa microsatellite Ndl_022 sequence -- -- -- -- Q96289 317 3.8e-28 Zinc finger protein ZAT10 OS=Arabidopsis thaliana GN=ZAT10 PE=2 SV=1 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-7225.0 BF_2 1.00 0.34 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7226.0 BF_2 2.00 0.38 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7227.0 BF_2 4.00 1.02 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7229.0 BF_2 7.00 1.60 470 767950668 XP_011542746.1 335 4.3e-29 PREDICTED: fibroblast growth factor receptor 1 isoform X2 [Homo sapiens] 188219627 NG_007729.1 470 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P11362 172 1.4e-11 Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3 PF15234 Linker for activation of T-cells GO:0007165 signal transduction -- -- GO:0016020 membrane -- -- Cluster-7236.0 BF_2 47.00 1.06 2140 478263496 ENN81851.1 1776 1.6e-195 hypothetical protein YQE_01789, partial [Dendroctonus ponderosae] 198457196 XM_001360549.2 35 3.37342e-06 Drosophila pseudoobscura pseudoobscura GA10155 (Dpse\GA10155), partial mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9NRA2 713 1.2e-73 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF04544//PF07690 Herpesvirus egress protein UL20//Major Facilitator Superfamily GO:0055085//GO:0019058 transmembrane transport//viral life cycle -- -- GO:0016021 integral component of membrane -- -- Cluster-7237.0 BF_2 8.97 0.65 861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7238.0 BF_2 6.00 1.36 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7239.0 BF_2 9.00 1.90 485 32307474 AAP79142.1 282 6.3e-23 ferredoxin 1 [Bigelowiella natans] -- -- -- -- -- K02639 petF ferredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K02639 Q9ZTS2 440 1.2e-42 Ferredoxin, chloroplastic OS=Capsicum annuum GN=AP1 PE=1 SV=1 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051536//GO:0009055 iron-sulfur cluster binding//electron carrier activity -- -- -- -- Cluster-7242.0 BF_2 6.00 0.77 612 470298698 XP_004346242.1 282 7.9e-23 ribosomal protein P0 [Capsaspora owczarzaki ATCC 30864]>gi|765554456|gb|KJE95077.1| ribosomal protein P0 [Capsaspora owczarzaki ATCC 30864] 255571860 XM_002526827.1 198 2.2682e-97 Ricinus communis 60S acidic ribosomal protein P0, putative, mRNA K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 Q42112 388 1.7e-36 60S acidic ribosomal protein P0-2 OS=Arabidopsis thaliana GN=RPP0B PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0815 60S acidic ribosomal protein P0 Cluster-7244.0 BF_2 15.00 1.61 678 620981748 XP_001515708.3 721 1.1e-73 PREDICTED: elongation factor 2 [Ornithorhynchus anatinus] 115446384 NM_001053507.1 675 0 Oryza sativa Japonica Group Os02g0519900 (Os02g0519900) mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 O23755 867 5.3e-92 Elongation factor 2 OS=Beta vulgaris PE=2 SV=1 PF01926 50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-7249.0 BF_2 2.00 0.46 469 -- -- -- -- -- 511666 D32136.1 424 0 RICPPA Oryza sativa endornavirus genomic RNA, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7255.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7257.0 BF_2 2.00 0.73 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7258.0 BF_2 13.15 0.96 862 -- -- -- -- -- 761231605 KM881639.1 862 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7258.1 BF_2 21.00 1.04 1128 196020247 XP_002119097.1 147 6.6e-07 hypothetical protein TRIADDRAFT_35144 [Trichoplax adhaerens]>gi|190576971|gb|EDV18417.1| hypothetical protein TRIADDRAFT_35144 [Trichoplax adhaerens] 761231605 KM881639.1 1125 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P0C474 352 4.6e-32 30S ribosomal protein S16, chloroplastic OS=Oryza sativa subsp. indica GN=rps16 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7260.0 BF_2 6.00 1.85 422 528226329 EPY24384.1 348 1.2e-30 serine/threonine kinase [Angomonas deanei] 645275757 XM_008244747.1 260 5.22672e-132 PREDICTED: Prunus mume CBL-interacting serine/threonine-protein kinase 6 (LOC103341255), mRNA K07198 PRKAA, AMPK 5'-AMP-activated protein kinase, catalytic alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07198 O65554 566 2.6e-57 CBL-interacting serine/threonine-protein kinase 6 OS=Arabidopsis thaliana GN=CIPK6 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-7260.1 BF_2 23.00 1.29 1033 290985475 XP_002675451.1 447 9.9e-42 serine/threonine protein kinase [Naegleria gruberi]>gi|284089047|gb|EFC42707.1| serine/threonine protein kinase [Naegleria gruberi] 595821892 XM_007204832.1 315 3.57584e-162 Prunus persica hypothetical protein (PRUPE_ppa006023mg) mRNA, complete cds K08799 MELK maternal embryonic leucine zipper kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08799 O65554 1064 1.2e-114 CBL-interacting serine/threonine-protein kinase 6 OS=Arabidopsis thaliana GN=CIPK6 PE=1 SV=1 PF03822//PF00069//PF07714 NAF domain//Protein kinase domain//Protein tyrosine kinase GO:0007165//GO:0006468 signal transduction//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-7261.0 BF_2 2.00 2.02 318 -- -- -- -- -- 182409984 EU588981.1 172 3.17728e-83 Betula platyphylla actin mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7264.0 BF_2 2.00 2.09 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7264.1 BF_2 1.00 0.98 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7267.0 BF_2 5.00 0.59 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7274.0 BF_2 7.00 1.69 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7277.0 BF_2 5.00 0.84 535 -- -- -- -- -- 523582254 KF015227.1 47 1.71407e-13 Conostigmus sp. MM-2013 mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7278.0 BF_2 5.00 0.93 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7283.0 BF_2 2.00 0.31 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7284.0 BF_2 1.00 0.45 378 861602714 KMQ83970.1 194 7.9e-13 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF01024//PF06645//PF00098 C2H2 zinc-finger//Colicin pore forming domain//Microsomal signal peptidase 12 kDa subunit (SPC12)//Zinc knuckle GO:0050829//GO:0019835//GO:0006465 defense response to Gram-negative bacterium//cytolysis//signal peptide processing GO:0003676//GO:0008270//GO:0008233 nucleic acid binding//zinc ion binding//peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-7294.0 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7297.0 BF_2 10.00 1.64 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10766 Multidrug efflux pump-associated protein AcrZ GO:0015893//GO:0006855 drug transport//drug transmembrane transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-7298.0 BF_2 1.00 0.46 376 767968735 XP_011543551.1 676 1.0e-68 PREDICTED: neuroblast differentiation-associated protein AHNAK isoform X2 [Homo sapiens] 767968734 XM_011545249.1 355 0 PREDICTED: Homo sapiens AHNAK nucleoprotein (AHNAK), transcript variant X3, mRNA -- -- -- -- Q09666 676 4.1e-70 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-7299.0 BF_2 10.00 1.60 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7304.0 BF_2 7.00 1.19 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7307.0 BF_2 17.49 10.85 350 -- -- -- -- -- 40794996 AY506529.1 347 1.84631e-180 Zea mays strain NB mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7309.0 BF_2 32.00 1.98 962 66800007 XP_628929.1 249 8.4e-19 O-methyltransferase family 2 protein [Dictyostelium discoideum AX4]>gi|74850460|sp|Q54B59.1|OMT12_DICDI RecName: Full=O-methyltransferase 12>gi|60462289|gb|EAL60515.1| O-methyltransferase family 2 protein [Dictyostelium discoideum AX4] 388494807 BT135675.1 184 2.20729e-89 Medicago truncatula clone JCVI-FLMt-11N6 unknown mRNA K00543 ASMT acetylserotonin N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00543 Q43609 756 5.6e-79 Caffeic acid 3-O-methyltransferase OS=Prunus dulcis GN=COMT1 PE=2 SV=1 PF00891 O-methyltransferase -- -- GO:0008171 O-methyltransferase activity -- -- -- -- Cluster-7310.0 BF_2 2.00 12.13 247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7311.0 BF_2 1.00 1.56 296 780661482 XP_011692937.1 182 1.5e-11 PREDICTED: protein NipSnap [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- Q9VXK0 175 4.0e-12 Protein NipSnap OS=Drosophila melanogaster GN=Nipsnap PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2883 NIPSNAP1 protein Cluster-7316.0 BF_2 3.00 4.99 293 829761174 XP_012619099.1 313 9.6e-27 PREDICTED: fibroblast growth factor receptor 2 isoform X9 [Microcebus murinus] 254553324 NG_012449.1 289 2.64388e-148 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21803 313 4.0e-28 Fibroblast growth factor receptor 2 OS=Mus musculus GN=Fgfr2 PE=1 SV=4 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-7323.0 BF_2 9.00 142.21 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7326.0 BF_2 4.08 0.62 561 821401745 XP_012390867.1 262 1.5e-20 PREDICTED: dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [Orcinus orca] 478431120 NG_001273.3 375 0 Homo sapiens mitogen-activated protein kinase kinase 1 pseudogene 1 (MAP2K1P1) on chromosome 8 K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q02750 259 1.4e-21 Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens GN=MAP2K1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-7326.1 BF_2 14.92 1.51 701 821401745 XP_012390867.1 655 5.1e-66 PREDICTED: dual specificity mitogen-activated protein kinase kinase 1 isoform X1 [Orcinus orca] 478431120 NG_001273.3 625 0 Homo sapiens mitogen-activated protein kinase kinase 1 pseudogene 1 (MAP2K1P1) on chromosome 8 K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q02750 537 1.0e-53 Dual specificity mitogen-activated protein kinase kinase 1 OS=Homo sapiens GN=MAP2K1 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-7330.0 BF_2 6.21 0.38 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7331.0 BF_2 5.00 0.69 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7333.0 BF_2 22.00 1.27 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7333.1 BF_2 10.00 0.84 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7333.2 BF_2 12.00 0.84 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7334.0 BF_2 13.00 1.68 611 723137477 XP_010285476.1 260 2.8e-20 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret-like [Phaethon lepturus] 336042955 JF276429.1 611 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 257 2.6e-21 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-7335.0 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7337.0 BF_2 74.00 2.32 1624 873240657 CEL93148.1 1628 1.8e-178 unnamed protein product [Vitrella brassicaformis CCMP3155] 306415950 GQ848037.1 1624 0 Oryza sativa Japonica Group clone KCG222G09 enolase mRNA, complete cds K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 Q42971 2210 2.4e-247 Enolase OS=Oryza sativa subsp. japonica GN=ENO1 PE=1 SV=2 PF00165//PF00113//PF03952//PF00927 Bacterial regulatory helix-turn-helix proteins, AraC family//Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain//Transglutaminase family, C-terminal ig like domain GO:0000162//GO:0006571//GO:0006355//GO:0006094//GO:0009094//GO:0018149//GO:0006096 tryptophan biosynthetic process//tyrosine biosynthetic process//regulation of transcription, DNA-templated//gluconeogenesis//L-phenylalanine biosynthetic process//peptide cross-linking//glycolytic process GO:0003700//GO:0000287//GO:0003810//GO:0043565//GO:0004634 transcription factor activity, sequence-specific DNA binding//magnesium ion binding//protein-glutamine gamma-glutamyltransferase activity//sequence-specific DNA binding//phosphopyruvate hydratase activity GO:0000015//GO:0005667 phosphopyruvate hydratase complex//transcription factor complex KOG2670 Enolase Cluster-7342.0 BF_2 2.00 0.64 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7346.0 BF_2 2.00 0.49 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7346.1 BF_2 5.00 0.73 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7348.0 BF_2 32.00 1.53 1161 470512637 XP_004352518.1 653 1.4e-65 asparaginase [Acanthamoeba castellanii str. Neff]>gi|440802102|gb|ELR23041.1| asparaginase [Acanthamoeba castellanii str. Neff] 593795691 XM_007160822.1 338 6.60062e-175 Phaseolus vulgaris hypothetical protein (PHAVU_001G025000g) mRNA, complete cds K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q8GXG1 1300 5.6e-142 Probable isoaspartyl peptidase/L-asparaginase 2 OS=Arabidopsis thaliana GN=At3g16150 PE=2 SV=2 PF01112//PF16672 Asparaginase//Ragulator complex protein LAMTOR5 GO:0019079//GO:0043066//GO:0043154 viral genome replication//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0016787 hydrolase activity GO:0071986//GO:0005737 Ragulator complex//cytoplasm KOG1592 Asparaginase Cluster-7350.1 BF_2 3.00 1.39 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7352.0 BF_2 2.00 2.92 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7354.0 BF_2 4.00 0.80 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06058 Dcp1-like decapping family GO:0043085//GO:0000290 positive regulation of catalytic activity//deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0008047 enzyme activator activity -- -- -- -- Cluster-7360.0 BF_2 2.00 0.32 549 34576920 AAQ75703.1 558 7.1e-55 benzodiazapine receptor (peripheral) [Homo sapiens]>gi|119593694|gb|EAW73288.1| benzodiazapine receptor (peripheral), isoform CRA_a [Homo sapiens] 375065826 NM_001256531.1 546 0 Homo sapiens translocator protein (18kDa) (TSPO), transcript variant 4, mRNA K05770 BZRP benzodiazapine receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05770 P30536 554 8.4e-56 Translocator protein OS=Homo sapiens GN=TSPO PE=1 SV=3 PF03073 TspO/MBR family GO:0010940//GO:0042493//GO:0014012//GO:0060252//GO:0071476//GO:0071222//GO:0008347//GO:0006820//GO:2000379//GO:0051928//GO:0050810//GO:0007568//GO:0010042//GO:0043065//GO:0051901//GO:0032374//GO:0030325//GO:0060242//GO:0006783//GO:0007165//GO:0033574//GO:0045019//GO:0007268//GO:0048266//GO:0006626//GO:0032720//GO:0010266//GO:0071294//GO:0060253//GO:0032570 positive regulation of necrotic cell death//response to drug//peripheral nervous system axon regeneration//positive regulation of glial cell proliferation//cellular hypotonic response//cellular response to lipopolysaccharide//glial cell migration//anion transport//positive regulation of reactive oxygen species metabolic process//positive regulation of calcium ion transport//regulation of steroid biosynthetic process//aging//response to manganese ion//positive regulation of apoptotic process//positive regulation of mitochondrial depolarization//regulation of cholesterol transport//adrenal gland development//contact inhibition//heme biosynthetic process//signal transduction//response to testosterone//negative regulation of nitric oxide biosynthetic process//synaptic transmission//behavioral response to pain//protein targeting to mitochondrion//negative regulation of tumor necrosis factor production//response to vitamin B1//cellular response to zinc ion//negative regulation of glial cell proliferation//response to progesterone GO:0008503//GO:0015485//GO:0005497 benzodiazepine receptor activity//cholesterol binding//androgen binding GO:0005741//GO:0016021 mitochondrial outer membrane//integral component of membrane KOG3797 Peripheral-type benzodiazepine receptor and related proteins Cluster-7362.0 BF_2 2.00 0.35 528 -- -- -- -- -- 333103101 JF715406.1 56 1.67821e-18 Scylla paramamosain clone SP22 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7369.0 BF_2 8.00 1.06 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7370.0 BF_2 16.40 1.08 923 484759913 YP_007890522.1 969 2.6e-102 NADH dehydrogenase subunit 5 (mitochondrion) [Andalucia godoyi]>gi|462269144|gb|AGH24016.1| NADH dehydrogenase subunit 5 (mitochondrion) [Andalucia godoyi] 167375204 EU414246.1 921 0 Bambusa oldhamii NADH dehydrogenase subunit 5 gene, complete cds; mitochondrial K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 P10330 1480 6.0e-163 NADH-ubiquinone oxidoreductase chain 5 OS=Oenothera berteroana GN=ND5 PE=2 SV=2 PF06455//PF03600 NADH dehydrogenase subunit 5 C-terminus//Citrate transporter GO:0042773//GO:0006120//GO:0055085//GO:0015992//GO:0055114//GO:0006814//GO:0006744 ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone//transmembrane transport//proton transport//oxidation-reduction process//sodium ion transport//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016021 integral component of membrane KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-7370.1 BF_2 13.60 1.67 628 11466551 NP_044800.1 331 1.7e-28 NADH dehydrogenase subunit 5 (mitochondrion) [Reclinomonas americana]>gi|2258381|gb|AAD11915.1| NADH dehydrogenase subunit 5 (mitochondrion) [Reclinomonas americana] 528540458 AP012528.1 613 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P10330 668 5.8e-69 NADH-ubiquinone oxidoreductase chain 5 OS=Oenothera berteroana GN=ND5 PE=2 SV=2 -- -- GO:0055114 oxidation-reduction process -- -- GO:0016020 membrane -- -- Cluster-7374.0 BF_2 8.00 1.65 490 831229103 XP_012661797.1 303 2.3e-25 PREDICTED: triosephosphate isomerase [Otolemur garnettii] 385717669 JN944359.1 484 0 Oryza sativa Japonica Group clone KCS165A04 triosephosphate isomerase mRNA, complete cds K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P48494 392 4.6e-37 Triosephosphate isomerase, cytosolic OS=Oryza sativa subsp. japonica GN=TPI PE=1 SV=3 PF00121 Triosephosphate isomerase GO:0008152//GO:0006096//GO:0006020//GO:0006094//GO:0015976//GO:0006013//GO:0046486//GO:0006000 metabolic process//glycolytic process//inositol metabolic process//gluconeogenesis//carbon utilization//mannose metabolic process//glycerolipid metabolic process//fructose metabolic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-7377.0 BF_2 3.00 0.41 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7379.0 BF_2 9.00 2.93 415 198434172 XP_002129244.1 321 1.6e-27 PREDICTED: 40S ribosomal protein S3 [Ciona intestinalis] 115453876 NM_001057074.1 415 0 Oryza sativa Japonica Group Os03g0577000 (Os03g0577000) mRNA, complete cds >gnl|BL_ORD_ID|3397611 Oryza sativa Japonica Group cDNA clone:006-205-G04, full insert sequence K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 Q9M339 373 6.2e-35 40S ribosomal protein S3-2 OS=Arabidopsis thaliana GN=RPS3B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3181 40S ribosomal protein S3 Cluster-7380.0 BF_2 3.00 0.32 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7382.0 BF_2 2.00 0.35 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7383.0 BF_2 7.00 2.94 385 817320165 XP_012330753.1 323 8.7e-28 PREDICTED: ALK tyrosine kinase receptor [Aotus nancymaae] 221554531 NG_009445.1 385 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 309 1.5e-27 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-7384.0 BF_2 3.00 0.76 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7390.0 BF_2 4.00 0.46 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7392.0 BF_2 2.00 0.69 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7394.0 BF_2 4.00 0.43 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7399.0 BF_2 9.00 3.09 408 1051276 AAB04940.1 563 1.4e-55 Hsp70 [Sterkiella nova] 670387502 XM_008676102.1 408 0 PREDICTED: Zea mays probable mediator of RNA polymerase II transcription subunit 37c (LOC103650526), mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9LHA8 638 1.1e-65 Probable mediator of RNA polymerase II transcription subunit 37c OS=Arabidopsis thaliana GN=MED37C PE=1 SV=1 PF06723//PF01968//PF01791 MreB/Mbl protein//Hydantoinase/oxoprolinase//DeoC/LacD family aldolase GO:0000902 cell morphogenesis GO:0016787//GO:0016829 hydrolase activity//lyase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-7402.0 BF_2 4.00 2.19 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7404.0 BF_2 3.00 1.08 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7405.0 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7407.0 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7410.0 BF_2 2.00 0.41 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7416.0 BF_2 19.00 2.31 631 470444416 XP_004339748.1 287 2.2e-23 glutaredoxin, putative [Acanthamoeba castellanii str. Neff]>gi|440796626|gb|ELR17735.1| glutaredoxin, putative [Acanthamoeba castellanii str. Neff] 15637349 AF406809.1 155 1.87627e-73 AF406809 Tilia platyphyllos glutaredoxin (Cl31) mRNA, complete cds K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q9ZR41 432 1.4e-41 Glutaredoxin OS=Solanum lycopersicum PE=3 SV=1 PF01323//PF13417//PF00462 DSBA-like thioredoxin domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035//GO:0005515 electron carrier activity//protein disulfide oxidoreductase activity//protein binding -- -- KOG1752 Glutaredoxin and related proteins Cluster-7417.0 BF_2 2.00 0.98 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7418.0 BF_2 1.00 0.38 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7422.0 BF_2 5.00 0.99 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7425.0 BF_2 9.00 1.13 619 470510788 XP_004351577.1 727 2.0e-74 ribosomal protein S7p/S5e, putative [Acanthamoeba castellanii str. Neff]>gi|440801795|gb|ELR22800.1| ribosomal protein S7p/S5e, putative [Acanthamoeba castellanii str. Neff] 157887846 CT841579.1 580 0 Oryza rufipogon (W1943) cDNA clone: ORW1943C102M01, full insert sequence K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 O65731 788 7.0e-83 40S ribosomal protein S5 (Fragment) OS=Cicer arietinum GN=RPS5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-7426.0 BF_2 3.00 1.05 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7427.0 BF_2 3.00 0.62 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7431.0 BF_2 4.00 0.42 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01348 Type II intron maturase GO:0006397 mRNA processing -- -- -- -- -- -- Cluster-7434.0 BF_2 1.00 0.67 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7436.0 BF_2 1.00 0.46 375 545214224 XP_003364867.2 296 1.1e-24 PREDICTED: mitochondrial import receptor subunit TOM7 homolog isoform X1 [Equus caballus]>gi|664704339|ref|XP_008533810.1| PREDICTED: mitochondrial import receptor subunit TOM7 homolog [Equus przewalskii] 409971398 NM_019059.3 375 0 Homo sapiens translocase of outer mitochondrial membrane 7 homolog (yeast) (TOMM7), mRNA K17771 TOM7 mitochondrial import receptor subunit TOM7 http://www.genome.jp/dbget-bin/www_bget?ko:K17771 Q9P0U1 288 4.0e-25 Mitochondrial import receptor subunit TOM7 homolog OS=Homo sapiens GN=TOMM7 PE=1 SV=1 PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-7438.0 BF_2 2.00 0.50 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7440.0 BF_2 1.00 0.53 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7442.0 BF_2 15.00 1.17 823 294933039 XP_002780567.1 294 4.3e-24 Endochitinase 3 precursor, putative [Perkinsus marinus ATCC 50983]>gi|239890501|gb|EER12362.1| Endochitinase 3 precursor, putative [Perkinsus marinus ATCC 50983] 702433244 XM_010071069.1 351 0 PREDICTED: Eucalyptus grandis chitinase-like protein 1 (LOC104456301), mRNA -- -- -- -- Q9MA41 1214 3.7e-132 Chitinase-like protein 1 OS=Arabidopsis thaliana GN=CTL1 PE=1 SV=1 PF00182 Chitinase class I GO:0006032//GO:0016998 chitin catabolic process//cell wall macromolecule catabolic process GO:0004568 chitinase activity -- -- -- -- Cluster-7445.0 BF_2 5.00 0.67 599 470437283 XP_004338972.1 431 4.1e-40 adenine nucleotide translocator, putative [Acanthamoeba castellanii str. Neff]>gi|440795845|gb|ELR16959.1| adenine nucleotide translocator, putative [Acanthamoeba castellanii str. Neff] 302915612 XM_003051571.1 254 1.64276e-128 Nectria haematococca mpVI 77-13-4 ADP/ATP carrier protein, partial mRNA K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 P02723 495 6.4e-49 ADP,ATP carrier protein OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=aac PE=3 SV=1 PF06596//PF01226 Photosystem II reaction centre X protein (PsbX)//Formate/nitrite transporter GO:0015979//GO:0006810 photosynthesis//transport GO:0005215 transporter activity GO:0016020//GO:0009523 membrane//photosystem II KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-7446.0 BF_2 8.00 1.99 455 795181610 XP_011800893.1 198 3.2e-13 PREDICTED: estradiol 17-beta-dehydrogenase 8 [Colobus angolensis palliatus] -- -- -- -- -- K13370 HSD17B8 17beta-estradiol 17-dehydrogenase / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K13370 Q5C9I9 304 6.8e-27 (-)-isopiperitenol/(-)-carveol dehydrogenase, mitochondrial OS=Mentha piperita PE=1 SV=1 PF08300//PF00106 Hepatitis C virus non-structural 5a zinc finger domain//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0008270 oxidoreductase activity//zinc ion binding -- -- -- -- Cluster-7447.0 BF_2 32.00 1.57 1141 557237089 CDJ60726.1 591 2.2e-58 CAM kinase, CDPK family, putative [Eimeria maxima] 115483173 NM_001071715.1 1135 0 Oryza sativa Japonica Group Os10g0539600 (Os10g0539600) mRNA, complete cds K13412 CPK calcium-dependent protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13412 P53682 1734 2.6e-192 Calcium-dependent protein kinase isoform 1 OS=Oryza sativa subsp. japonica GN=SPK PE=2 SV=2 PF05445//PF00075//PF00069//PF06293//PF07714 Poxvirus serine/threonine protein kinase//RNase H//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0051252//GO:0006468 regulation of RNA metabolic process//protein phosphorylation GO:0016773//GO:0003676//GO:0004523//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//nucleic acid binding//RNA-DNA hybrid ribonuclease activity//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-7449.0 BF_2 1.00 0.31 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7450.0 BF_2 1.00 1.19 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7452.0 BF_2 3.00 5.23 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7452.1 BF_2 1.00 1.32 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7453.0 BF_2 11.00 4.95 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7463.0 BF_2 1.00 0.72 339 694987226 XP_009438248.1 324 5.9e-28 PREDICTED: neuroblastoma breakpoint family member 12-like [Pan troglodytes] 694987404 XM_009440024.1 285 5.20688e-146 PREDICTED: Pan troglodytes neuroblastoma breakpoint family member 12-like (LOC747233), mRNA -- -- -- -- Q5TI25 270 4.4e-23 Neuroblastoma breakpoint family member 14 OS=Homo sapiens GN=NBPF14 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-7464.0 BF_2 2.00 0.40 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7467.0 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7470.0 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7471.0 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7476.0 BF_2 1.00 1.19 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7481.0 BF_2 3.00 0.41 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7486.0 BF_2 2.00 0.35 524 544512357 XP_005596121.1 324 9.1e-28 PREDICTED: LOW QUALITY PROTEIN: selenoprotein W, 1 [Macaca fascicularis]>gi|795084769|ref|XP_011825273.1| PREDICTED: LOW QUALITY PROTEIN: selenoprotein W [Mandrillus leucophaeus] 42544245 NM_003009.2 524 0 Homo sapiens selenoprotein W, 1 (SEPW1), mRNA -- -- -- -- P63302 291 2.5e-25 Selenoprotein W OS=Homo sapiens GN=SEPW1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-7491.0 BF_2 1.00 0.50 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7504.0 BF_2 6.00 2.64 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01613 Flavin reductase like domain -- -- GO:0010181 FMN binding -- -- -- -- Cluster-7509.0 BF_2 8.00 3.79 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7511.0 BF_2 7.00 0.43 962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7513.0 BF_2 5.00 1.12 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7515.0 BF_2 36.00 2.37 922 295443946 BAJ06408.1 1081 2.7e-115 eukaryotic translation elongation factor 2 [Palpitomonas bilix] 119395215 EF122482.1 919 0 Oryza sativa (japonica cultivar-group) clone KCS059F08 elongation factor 2 mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 O23755 1444 8.9e-159 Elongation factor 2 OS=Beta vulgaris PE=2 SV=1 PF03144 Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-7517.0 BF_2 2.00 3.12 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7519.0 BF_2 31.00 4.99 547 -- -- -- -- -- 116011284 AK241919.1 526 0 Oryza sativa Japonica Group cDNA, clone: J075074E04, full insert sequence >gnl|BL_ORD_ID|4566812 Oryza sativa Japonica Group cDNA, clone: J075093G10, full insert sequence -- -- -- -- P20698 204 3.2e-15 Prolamin PPROL 17D OS=Oryza sativa subsp. japonica GN=Os12g0269200 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-7521.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7523.0 BF_2 7.00 2.31 413 -- -- -- -- -- 802546364 XM_012229165.1 83 1.26422e-33 PREDICTED: Jatropha curcas photosystem I reaction center subunit XI, chloroplastic (LOC105643922), mRNA -- -- -- -- Q39654 419 2.9e-40 Photosystem I reaction center subunit XI, chloroplastic OS=Cucumis sativus GN=PSAL PE=2 SV=1 PF02605 Photosystem I reaction centre subunit XI GO:0015979 photosynthesis -- -- GO:0009538//GO:0009522 photosystem I reaction center//photosystem I -- -- Cluster-7525.0 BF_2 4.00 0.41 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7527.0 BF_2 4.00 0.65 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7529.0 BF_2 3.00 0.58 504 556758396 XP_005974531.1 507 5.3e-49 PREDICTED: uncharacterized protein LOC102328608 [Pantholops hodgsonii] 731409079 XM_002282071.3 363 0 PREDICTED: Vitis vinifera ATP-dependent zinc metalloprotease FTSH 2, chloroplastic (LOC100250511), mRNA K08956 AFG3 AFG3 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K08956 Q655S1 677 4.2e-70 ATP-dependent zinc metalloprotease FTSH 2, chloroplastic OS=Oryza sativa subsp. japonica GN=FTSH2 PE=3 SV=1 PF00004//PF15332 ATPase family associated with various cellular activities (AAA)//Lck-interacting transmembrane adapter 1 GO:0050852//GO:0050853 T cell receptor signaling pathway//B cell receptor signaling pathway GO:0005524 ATP binding -- -- KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-7530.0 BF_2 3.00 0.37 630 478250813 ENN71305.1 284 4.8e-23 hypothetical protein YQE_12230, partial [Dendroctonus ponderosae]>gi|546679731|gb|ERL90146.1| hypothetical protein D910_07500, partial [Dendroctonus ponderosae] -- -- -- -- -- K03440 ASICN amiloride-sensitive sodium channel, other http://www.genome.jp/dbget-bin/www_bget?ko:K03440 -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-7531.0 BF_2 8.00 0.38 1169 -- -- -- -- -- 642917571 XM_008193040.1 82 1.35605e-32 PREDICTED: Tribolium castaneum uncharacterized LOC103312431 (LOC103312431), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7531.1 BF_2 5.00 0.49 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7535.0 BF_2 2.00 0.63 419 578809198 XP_006714308.1 504 9.8e-49 PREDICTED: odontogenic ameloblast-associated protein isoform X3 [Homo sapiens] 767932170 XM_006714245.2 413 0 PREDICTED: Homo sapiens odontogenic, ameloblast asssociated (ODAM), transcript variant X3, mRNA -- -- -- -- A1E959 424 7.6e-41 Odontogenic ameloblast-associated protein OS=Homo sapiens GN=ODAM PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7537.0 BF_2 4.00 0.69 530 635036204 XP_007993519.1 815 1.1e-84 PREDICTED: calponin-1 [Chlorocebus sabaeus] 816197618 NM_001299.5 530 0 Homo sapiens calponin 1, basic, smooth muscle (CNN1), transcript variant 1, mRNA -- -- -- -- P51911 748 2.6e-78 Calponin-1 OS=Homo sapiens GN=CNN1 PE=1 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-7538.0 BF_2 6.00 0.66 667 91079476 XP_967809.1 435 1.6e-40 PREDICTED: cytochrome b5 [Tribolium castaneum]>gi|270003450|gb|EEZ99897.1| hypothetical protein TcasGA2_TC002681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49097 201 8.7e-15 Cytochrome b5 OS=Cuscuta reflexa PE=2 SV=1 -- -- -- -- GO:0005488 binding -- -- KOG0537 Cytochrome b5 Cluster-7539.0 BF_2 1.00 1.46 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7545.1 BF_2 3.00 0.76 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7548.0 BF_2 3.00 0.38 614 308197282 ADO17753.1 918 1.4e-96 single-minded protein [Parhyale hawaiensis] 742195540 XM_010893585.1 144 2.37474e-67 PREDICTED: Esox lucius single-minded family bHLH transcription factor 2 (sim2), transcript variant X4, mRNA K09100 SIM single-minded http://www.genome.jp/dbget-bin/www_bget?ko:K09100 A2T6X9 855 1.2e-90 Single-minded homolog 1 OS=Pan troglodytes GN=SIM1 PE=3 SV=1 PF00989//PF08447 PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-7549.0 BF_2 13.48 2.55 508 700354676 XP_009921627.1 277 2.5e-22 PREDICTED: glycine-rich RNA-binding protein GRP1A-like, partial [Haliaeetus albicilla] 385718873 JF969238.1 471 0 Oryza sativa clone KCB741C11 Glycin-rich RNA binding protein mRNA, complete cds K13195 CIRBP cold-inducible RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13195 P49310 398 9.6e-38 Glycine-rich RNA-binding protein GRP1A OS=Sinapis alba PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-7550.0 BF_2 19.00 1.89 708 857972446 CEP01483.1 665 3.5e-67 hypothetical protein PBRA_002089 [Plasmodiophora brassicae] 1944512 Y08681.1 444 0 A.glutinosa mRNA for glutamine synthetase K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 P51118 962 5.3e-103 Glutamine synthetase cytosolic isozyme 1 OS=Vitis vinifera GN=GS1-1 PE=2 SV=1 PF00120//PF09830 Glutamine synthetase, catalytic domain//ATP adenylyltransferase GO:0009252//GO:0006144//GO:0006807 peptidoglycan biosynthetic process//purine nucleobase metabolic process//nitrogen compound metabolic process GO:0004356//GO:0003877 glutamate-ammonia ligase activity//ATP adenylyltransferase activity -- -- KOG0683 Glutamine synthetase Cluster-7554.0 BF_2 6.00 0.93 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7554.1 BF_2 5.00 1.03 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7555.0 BF_2 1.00 3.52 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7558.0 BF_2 2.00 0.36 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7560.0 BF_2 2.00 0.35 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7562.0 BF_2 13.00 1.25 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7563.0 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7564.0 BF_2 2.00 0.34 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7567.0 BF_2 1.00 0.65 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7571.0 BF_2 17.00 1.88 665 -- -- -- -- -- 255545401 XM_002513715.1 276 1.08099e-140 Ricinus communis Photosystem II 22 kDa protein, chloroplast precursor, putative, mRNA -- -- -- -- Q02060 738 4.7e-77 Photosystem II 22 kDa protein, chloroplastic OS=Spinacia oleracea GN=PSBS PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7573.0 BF_2 2.00 0.49 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7580.0 BF_2 1.00 1.43 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7581.2 BF_2 3.00 1.35 378 307197437 EFN78684.1 178 5.6e-11 hypothetical protein EAI_06698, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7585.0 BF_2 5.00 0.32 932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7586.0 BF_2 4.00 0.98 457 585684387 XP_006812571.1 453 8.8e-43 PREDICTED: 40S ribosomal protein S20-like [Saccoglossus kowalevskii] 823121330 XM_012608376.1 224 5.86051e-112 PREDICTED: Gossypium raimondii 40S ribosomal protein S20-2-like (LOC105783068), transcript variant X2, mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P49200 548 3.5e-55 40S ribosomal protein S20-1 OS=Arabidopsis thaliana GN=RPS20A PE=2 SV=2 PF04726 Microvirus J protein -- -- GO:0003677 DNA binding -- -- KOG0900 40S ribosomal protein S20 Cluster-7592.0 BF_2 8.00 0.87 671 295314944 ADF97622.1 766 6.5e-79 ribosomal protein S11 [Hypophthalmichthys molitrix] 295314943 HM124760.1 431 0 Hypophthalmichthys molitrix ribosomal protein S11 mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P62282 690 1.7e-71 40S ribosomal protein S11 OS=Rattus norvegicus GN=Rps11 PE=1 SV=3 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1728 40S ribosomal protein S11 Cluster-7593.0 BF_2 5.00 1.44 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7593.1 BF_2 5.00 0.56 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-76.0 BF_2 1.00 0.54 361 91088161 XP_976346.1 162 3.8e-09 PREDICTED: uncharacterized protein LOC660496 [Tribolium castaneum]>gi|270012122|gb|EFA08570.1| hypothetical protein TcasGA2_TC006225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7601.0 BF_2 2.00 0.38 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7604.0 BF_2 5.67 0.65 651 270017072 EFA13518.1 507 6.8e-49 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10394 378 2.6e-35 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-7605.0 BF_2 7.00 1.93 438 290980759 XP_002673099.1 290 6.7e-24 predicted protein [Naegleria gruberi]>gi|284086680|gb|EFC40355.1| predicted protein [Naegleria gruberi] 590604049 XM_007020099.1 162 1.63544e-77 Theobroma cacao 12-oxophytodienoate reductase 2 (TCM_036537) mRNA, complete cds -- -- -- -- B9FSC8 481 2.0e-47 Putative 12-oxophytodienoate reductase 11 OS=Oryza sativa subsp. japonica GN=OPR11 PE=2 SV=1 PF00724 NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- KOG0134 NADH:flavin oxidoreductase/12-oxophytodienoate reductase Cluster-7607.0 BF_2 9.00 1.38 559 148235098 NP_001091345.1 682 3.0e-69 uncharacterized protein LOC100037184 [Xenopus laevis]>gi|125858902|gb|AAI29593.1| LOC100037184 protein [Xenopus laevis] 530684263 JX972165.1 559 0 Oryza sativa Japonica Group clone KCS021E01 ribosomal protein L3 mRNA, complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 P35684 892 5.5e-95 60S ribosomal protein L3 OS=Oryza sativa subsp. japonica GN=RPL3 PE=2 SV=2 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-7608.0 BF_2 2.00 1.36 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7614.0 BF_2 8.00 31.80 260 114794487 2HRB 448 1.9e-42 Chain A, Crystal Structure Of Human Carbonyl Reductase 3, Complexed With Nadp+ 133923362 EF462915.1 260 3.05004e-132 Homo sapiens carbonyl reductase 3 (CBR3) gene, complete cds K00084 CBR3 carbonyl reductase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K00084 O75828 448 7.8e-44 Carbonyl reductase [NADPH] 3 OS=Homo sapiens GN=CBR3 PE=1 SV=3 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-7616.0 BF_2 5.00 1.38 438 751770880 XP_011202004.1 139 2.2e-06 PREDICTED: cytochrome P450 307a1-like [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q9LSF8 240 1.7e-19 Cytochrome P450 82G1 OS=Arabidopsis thaliana GN=CYP82G1 PE=1 SV=1 PF00067//PF06297 Cytochrome P450//PET Domain GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0008270//GO:0016705 heme binding//iron ion binding//zinc ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-7619.0 BF_2 1.00 1.26 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7627.0 BF_2 1.00 2.16 282 270004778 EFA01226.1 390 1.1e-35 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 325 1.5e-29 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-7628.0 BF_2 7.00 2.37 410 -- -- -- -- -- 743886928 XM_011039681.1 69 7.60215e-26 PREDICTED: Populus euphratica dirigent protein 19-like (LOC105135008), mRNA -- -- -- -- Q9C523 378 1.6e-35 Dirigent protein 19 OS=Arabidopsis thaliana GN=DIR19 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7631.0 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7632.0 BF_2 2.00 0.95 373 161728797 BAF94212.1 242 2.1e-18 33kDa oxygen evolving protein of photosystem II [Chlorarachnion reptans] 568824609 XM_006466627.1 205 1.71431e-101 PREDICTED: Citrus sinensis oxygen-evolving enhancer protein 1, chloroplastic-like (LOC102621051), mRNA -- -- -- -- P26320 581 4.2e-59 Oxygen-evolving enhancer protein 1, chloroplastic OS=Solanum tuberosum GN=PSBO PE=2 SV=1 PF01716 Manganese-stabilising protein / photosystem II polypeptide GO:0042549//GO:0015979 photosystem II stabilization//photosynthesis GO:0005509 calcium ion binding GO:0009523//GO:0009654//GO:0019898 photosystem II//photosystem II oxygen evolving complex//extrinsic component of membrane -- -- Cluster-7633.0 BF_2 2.00 0.50 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7635.0 BF_2 8.00 0.34 1261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-7637.0 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7643.1 BF_2 13.00 0.70 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7644.0 BF_2 7.00 3.05 381 333449424 AEF33398.1 250 2.5e-19 glyceraldehyde 3-phosphate dehydrogenase protein [Crassostrea ariakensis] 347661276 BT131629.1 381 0 Oryza sativa clone RRlibC00642 mRNA sequence K10705 GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic http://www.genome.jp/dbget-bin/www_bget?ko:K10705 Q7FAH2 312 6.7e-28 Glyceraldehyde-3-phosphate dehydrogenase 2, cytosolic OS=Oryza sativa subsp. japonica GN=GAPC2 PE=1 SV=1 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-7645.0 BF_2 10.00 0.39 1353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7646.0 BF_2 2.00 0.31 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7648.0 BF_2 50.00 6.10 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7648.1 BF_2 2.00 1.63 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7651.0 BF_2 1.00 0.43 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7652.0 BF_2 5.00 0.96 506 861619174 KMQ86966.1 203 9.5e-14 fatty acid synthase, partial [Lasius niger] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 196 2.5e-14 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-7666.0 BF_2 9.00 1.21 598 541040834 ERG80224.1 813 2.1e-84 gtp-binding nuclear protein ran [Ascaris suum] 731407143 XM_002284982.3 370 0 PREDICTED: Vitis vinifera GTP-binding nuclear protein Ran-3-like (LOC100250818), mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 P54766 1019 1.1e-109 GTP-binding nuclear protein Ran1B (Fragment) OS=Lotus japonicus GN=RAN1B PE=2 SV=1 PF00071//PF00025//PF00910//PF08477 Ras family//ADP-ribosylation factor family//RNA helicase//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0003723//GO:0003724 GTP binding//RNA binding//RNA helicase activity -- -- KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-7668.0 BF_2 14.00 0.92 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7671.0 BF_2 13.56 0.90 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7679.1 BF_2 3.00 0.88 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7680.0 BF_2 3.00 0.72 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7682.0 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7683.0 BF_2 1.00 0.52 364 642920523 XP_008192386.1 269 1.5e-21 PREDICTED: cytoplasmic dynein 2 heavy chain 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7686.0 BF_2 3.00 0.54 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7688.0 BF_2 9.00 2.68 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P45726 380 9.8e-36 Phenylalanine ammonia-lyase OS=Camellia sinensis GN=PAL PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7690.0 BF_2 1.00 0.94 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7691.0 BF_2 12.00 1.46 630 537180484 ERE75886.1 430 5.6e-40 pro-cathepsin H-like protein [Cricetulus griseus] 731406315 XM_002278588.3 232 2.94106e-116 PREDICTED: Vitis vinifera thiol protease aleurain-like (LOC100244107), transcript variant X1, mRNA K01366 CTSH cathepsin H http://www.genome.jp/dbget-bin/www_bget?ko:K01366 Q8RWQ9 621 1.6e-63 Thiol protease aleurain-like OS=Arabidopsis thaliana GN=At3g45310 PE=2 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-7699.0 BF_2 4.00 0.36 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7703.0 BF_2 2.00 0.89 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7705.0 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7706.0 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7708.0 BF_2 2.00 0.36 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7708.1 BF_2 2.00 0.47 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7710.0 BF_2 2.52 0.32 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7712.0 BF_2 13.00 0.99 839 820696473 CEL72208.1 144 1.1e-06 TPA: asparagine synthase, putative [Toxoplasma gondii VEG] 116639686 CT829647.1 839 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCSN047C11, full insert sequence -- -- -- -- P24805 294 1.8e-25 Stem-specific protein TSJT1 OS=Nicotiana tabacum GN=TSJT1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7713.0 BF_2 8.00 1.66 489 795574939 XP_011722205.1 277 2.4e-22 PREDICTED: smoothened homolog isoform X1 [Macaca nemestrina] 300360510 NG_023340.1 489 0 Homo sapiens smoothened, frizzled class receptor (SMO), RefSeqGene on chromosome 7 K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 Q99835 259 1.2e-21 Smoothened homolog OS=Homo sapiens GN=SMO PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7723.0 BF_2 8.00 1.79 474 14277700 NP_001007.2 687 6.7e-70 40S ribosomal protein S12 [Homo sapiens]>gi|40254577|ref|NP_035425.2| 40S ribosomal protein S12 [Mus musculus]>gi|47523784|ref|NP_999528.1| 40S ribosomal protein S12 [Sus scrofa]>gi|62461611|ref|NP_001014409.1| 40S ribosomal protein S12 [Bos taurus]>gi|78126139|ref|NP_113897.2| 40S ribosomal protein S12 [Rattus norvegicus]>gi|307548916|ref|NP_001182594.1| ribosomal protein S12 [Macaca mulatta]>gi|357394894|ref|NP_001239438.1| 40S ribosomal protein S12 [Pan troglodytes]>gi|756140972|ref|NP_001291842.1| 40S ribosomal protein S12 [Ailuropoda melanoleuca]>gi|827834182|ref|NP_001296410.1| ribosomal protein S12 [Equus caballus]>gi|73945531|ref|XP_849673.1| PREDICTED: 40S ribosomal protein S12 isoform 2 [Canis lupus familiaris]>gi|109082720|ref|XP_001094299.1| PREDICTED: 40S ribosomal protein S12-like isoform 1 [Macaca mulatta]>gi|109082722|ref|XP_001094427.1| PREDICTED: 40S ribosomal protein S12-like isoform 2 [Macaca mulatta]>gi|126310576|ref|XP_001369942.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Monodelphis domestica]>gi|291397006|ref|XP_002714875.1| PREDICTED: 40S ribosomal protein S12 [Oryctolagus cuniculus]>gi|296199284|ref|XP_002747020.1| PREDICTED: 40S ribosomal protein S12 [Callithrix jacchus]>gi|296224017|ref|XP_002757870.1| PREDICTED: 40S ribosomal protein S12 [Callithrix jacchus]>gi|297679194|ref|XP_002817426.1| PREDICTED: 40S ribosomal protein S12 [Pongo abelii]>gi|301765404|ref|XP_002918123.1| PREDICTED: 40S ribosomal protein S12 [Ailuropoda melanoleuca]>gi|301792108|ref|XP_002931021.1| PREDICTED: 40S ribosomal protein S12 [Ailuropoda melanoleuca]>gi|332213337|ref|XP_003255776.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Nomascus leucogenys]>gi|345328507|ref|XP_001506584.2| PREDICTED: 40S ribosomal protein S12 [Ornithorhynchus anatinus]>gi|348559730|ref|XP_003465668.1| PREDICTED: 40S ribosomal protein S12 [Cavia porcellus]>gi|395534957|ref|XP_003769499.1| PREDICTED: 40S ribosomal protein S12 [Sarcophilus harrisii]>gi|397514923|ref|XP_003827718.1| PREDICTED: 40S ribosomal protein S12 [Pan paniscus]>gi|402875283|ref|XP_003901441.1| PREDICTED: 40S ribosomal protein S12 [Papio anubis]>gi|410960072|ref|XP_003986621.1| PREDICTED: 40S ribosomal protein S12 [Felis catus]>gi|426234823|ref|XP_004011391.1| PREDICTED: 40S ribosomal protein S12 [Ovis aries]>gi|465973889|ref|XP_004263859.1| PREDICTED: 40S ribosomal protein S12 [Orcinus orca]>gi|470637525|ref|XP_004324074.1| PREDICTED: 40S ribosomal protein S12-like [Tursiops truncatus]>gi|471356733|ref|XP_004368965.1| PREDICTED: 40S ribosomal protein S12 [Trichechus manatus latirostris]>gi|472363309|ref|XP_004401231.1| PREDICTED: 40S ribosomal protein S12 [Odobenus rosmarus divergens]>gi|478496099|ref|XP_004422390.1| PREDICTED: 40S ribosomal protein S12 [Ceratotherium simum simum]>gi|504149798|ref|XP_004587300.1| PREDICTED: 40S ribosomal protein S12 [Ochotona princeps]>gi|507534387|ref|XP_004651249.1| PREDICTED: 40S ribosomal protein S12 [Jaculus jaculus]>gi|507641126|ref|XP_004630330.1| PREDICTED: 40S ribosomal protein S12 [Octodon degus]>gi|507643111|ref|XP_004702051.1| PREDICTED: 40S ribosomal protein S12 [Echinops telfairi]>gi|507925304|ref|XP_004673918.1| PREDICTED: 40S ribosomal protein S12 [Condylura cristata]>gi|511831205|ref|XP_004740281.1| PREDICTED: 40S ribosomal protein S12 [Mustela putorius furo]>gi|512987129|ref|XP_004855501.1| PREDICTED: 40S ribosomal protein S12 [Heterocephalus glaber]>gi|524923238|ref|XP_005065871.1| PREDICTED: 40S ribosomal protein S12 [Mesocricetus auratus]>gi|528960983|ref|XP_005210987.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Bos taurus]>gi|528960985|ref|XP_005210988.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Bos taurus]>gi|530567682|ref|XP_005280353.1| PREDICTED: 40S ribosomal protein S12 [Chrysemys picta bellii]>gi|532036197|ref|XP_005360989.1| PREDICTED: 40S ribosomal protein S12 [Microtus ochrogaster]>gi|533150012|ref|XP_005389277.1| PREDICTED: 40S ribosomal protein S12 [Chinchilla lanigera]>gi|544425329|ref|XP_005551928.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Macaca fascicularis]>gi|548480042|ref|XP_005684830.1| PREDICTED: 40S ribosomal protein S12 [Capra hircus]>gi|554528552|ref|XP_005859085.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Myotis brandtii]>gi|554528554|ref|XP_005859086.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Myotis brandtii]>gi|555951203|ref|XP_005887800.1| PREDICTED: 40S ribosomal protein S12 [Bos mutus]>gi|558105829|ref|XP_006084527.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Myotis lucifugus]>gi|558105832|ref|XP_006084528.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Myotis lucifugus]>gi|558175369|ref|XP_006100015.1| PREDICTED: 40S ribosomal protein S12-like [Myotis lucifugus]>gi|560924655|ref|XP_006188515.1| PREDICTED: 40S ribosomal protein S12 [Camelus ferus]>gi|560955281|ref|XP_006200131.1| PREDICTED: 40S ribosomal protein S12 [Vicugna pacos]>gi|562829678|ref|XP_006144384.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Tupaia chinensis]>gi|562829680|ref|XP_006144385.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Tupaia chinensis]>gi|584063788|ref|XP_006776280.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Myotis davidii]>gi|584063790|ref|XP_006776281.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Myotis davidii]>gi|585149186|ref|XP_006727098.1| PREDICTED: 40S ribosomal protein S12-like [Leptonychotes weddellii]>gi|589919014|ref|XP_006972708.1| PREDICTED: 40S ribosomal protein S12-like [Peromyscus maniculatus bairdii]>gi|589948150|ref|XP_006986740.1| PREDICTED: 40S ribosomal protein S12-like [Peromyscus maniculatus bairdii]>gi|591303663|ref|XP_007078663.1| PREDICTED: 40S ribosomal protein S12 [Panthera tigris altaica]>gi|593770108|ref|XP_007123445.1| PREDICTED: 40S ribosomal protein S12-like [Physeter catodon]>gi|594070964|ref|XP_006059357.1| PREDICTED: 40S ribosomal protein S12 [Bubalus bubalis]>gi|594686981|ref|XP_007190944.1| PREDICTED: 40S ribosomal protein S12 [Balaenoptera acutorostrata scammoni]>gi|602688738|ref|XP_007456588.1| PREDICTED: 40S ribosomal protein S12 [Lipotes vexillifer]>gi|611998367|ref|XP_007484642.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Monodelphis domestica]>gi|625219162|ref|XP_007649687.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Cricetulus griseus]>gi|625272915|ref|XP_007628030.1| PREDICTED: 40S ribosomal protein S12 isoform X2 [Cricetulus griseus]>gi|634866440|ref|XP_007945571.1| PREDICTED: 40S ribosomal protein S12 [Orycteropus afer afer]>gi|635076368|ref|XP_008005189.1| PREDICTED: 40S ribosomal protein S12 [Chlorocebus sabaeus]>gi|640801055|ref|XP_008056800.1| PREDICTED: 40S ribosomal protein S12 [Tarsius syrichta]>gi|641690834|ref|XP_008160578.1| PREDICTED: 40S ribosomal protein S12 [Eptesicus fuscus]>gi|664740687|ref|XP_008527644.1| PREDICTED: 40S ribosomal protein S12 [Equus przewalskii]>gi|667246893|ref|XP_008585191.1| PREDICTED: 40S ribosomal protein S12 [Galeopterus variegatus]>gi|670996843|ref|XP_008689298.1| PREDICTED: 40S ribosomal protein S12 [Ursus maritimus]>gi|670996845|ref|XP_008689299.1| PREDICTED: 40S ribosomal protein S12 [Ursus maritimus]>gi|674094113|ref|XP_008820326.1| PREDICTED: 40S ribosomal protein S12 [Nannospalax galili]>gi|686723408|ref|XP_009240539.1| PREDICTED: 40S ribosomal protein S12 [Pongo abelii]>gi|724827537|ref|XP_010362357.1| PREDICTED: 40S ribosomal protein S12 [Rhinopithecus roxellana]>gi|724965896|ref|XP_010356188.1| PREDICTED: 40S ribosomal protein S12 [Rhinopithecus roxellana]>gi|731221524|ref|XP_010624953.1| PREDICTED: 40S ribosomal protein S12 [Fukomys damarensis]>gi|731453102|ref|XP_010589537.1| PREDICTED: 40S ribosomal protein S12 [Loxodonta africana]>gi|742141208|ref|XP_010842579.1| PREDICTED: 40S ribosomal protein S12 [Bison bison bison]>gi|742141210|ref|XP_010842580.1| PREDICTED: 40S ribosomal protein S12 [Bison bison bison]>gi|743738940|ref|XP_010963888.1| PREDICTED: 40S ribosomal protein S12 [Camelus bactrianus]>gi|744590453|ref|XP_010986995.1| PREDICTED: 40S ribosomal protein S12 [Camelus dromedarius]>gi|759108676|ref|XP_011354505.1| PREDICTED: 40S ribosomal protein S12 [Pteropus vampyrus]>gi|795134527|ref|XP_011791282.1| PREDICTED: 40S ribosomal protein S12 [Colobus angolensis palliatus]>gi|795316424|ref|XP_011817532.1| PREDICTED: 40S ribosomal protein S12 [Colobus angolensis palliatus]>gi|795345008|ref|XP_011930484.1| PREDICTED: 40S ribosomal protein S12 [Cercocebus atys]>gi|795421089|ref|XP_011947049.1| PREDICTED: 40S ribosomal protein S12 [Cercocebus atys]>gi|795457086|ref|XP_011765416.1| PREDICTED: 40S ribosomal protein S12 [Macaca nemestrina]>gi|803311668|ref|XP_012014154.1| PREDICTED: 40S ribosomal protein S12 [Ovis aries musimon]>gi|817318461|ref|XP_012329916.1| PREDICTED: 40S ribosomal protein S12 isoform X1 [Aotus nancymaae]>gi|826352827|ref|XP_012520665.1| PREDICTED: 40S ribosomal protein S12 [Propithecus coquereli]>gi|829907849|ref|XP_012592098.1| PREDICTED: 40S ribosomal protein S12 [Microcebus murinus]>gi|831226710|ref|XP_012660908.1| PREDICTED: 40S ribosomal protein S12 [Otolemur garnettii]>gi|859859308|ref|XP_012919002.1| PREDICTED: 40S ribosomal protein S12 [Mustela putorius furo]>gi|1173191|sp|P46405.2|RS12_PIG RecName: Full=40S ribosomal protein S12>gi|75072496|sp|Q76I81.1|RS12_BOVIN RecName: Full=40S ribosomal protein S12 [Bos taurus]>gi|224471878|sp|P25398.3|RS12_HUMAN RecName: Full=40S ribosomal protein S12>gi|529281362|pdb|4KZX|M Chain M, Rabbit 40s Ribosomal Subunit In Complex With Eif1.>gi|529281397|pdb|4KZY|M Chain M, Rabbit 40s Ribosomal Subunit In Complex With Eif1 And Eif1a.>gi|529281433|pdb|4KZZ|M Chain M, Rabbit 40s Ribosomal Subunit In Complex With Mrna, Initiator Trna And Eif1a>gi|665764238|pdb|4CXC|M Chain M, Regulation Of The Mammalian Elongation Cycle By 40s Subunit Rolling: A Eukaryotic-specific Ribosome Rearrangement>gi|672884484|pdb|4UQ4|M Chain M, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Post-like State>gi|672884518|pdb|4UQ5|M Chain M, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Pre-like State>gi|753536052|pdb|4D5L|M Chain M, Cryo-em Structures Of Ribosomal 80s Complexes With Termination Factors And Cricket Paralysis Virus Ires Reveal The Ires In The Translocated State>gi|764090871|pdb|4D61|M Chain M, Cryo-em Structures Of Ribosomal 80s Complexes With Termination Factors And Cricket Paralysis Virus Ires Reveal The Ires In The Translocated State>gi|887492891|pdb|5A2Q|M Chain M, Structure Of The Hcv Ires Bound To The Human Ribosome>gi|872315|emb|CAA55946.1| 40S ribosomal protein S12 [Sus scrofa]>gi|12805235|gb|AAH02079.1| Ribosomal protein S12 [Mus musculus]>gi|12833134|dbj|BAB22404.1| unnamed protein product [Mus musculus]>gi|12842004|dbj|BAB25433.1| unnamed protein product [Mus musculus]>gi|16878247|gb|AAH17321.1| Ribosomal protein S12 [Homo sapiens]>gi|17932974|dbj|BAB79478.1| ribosomal protein S12 [Homo sapiens]>gi|26328541|dbj|BAC28009.1| unnamed protein product [Mus musculus]>gi|28189913|dbj|BAC56571.1| similar to ribosomal protein S12 [Bos taurus]>gi|34849622|gb|AAH58460.1| Ribosomal protein S12 [Rattus norvegicus]>gi|42564210|gb|AAS20599.1| ribosomal protein S12 [Bos taurus]>gi|47940604|gb|AAH71930.1| Ribosomal protein S12 [Homo sapiens]>gi|58476931|gb|AAH89339.1| Ribosomal protein S12 [Mus musculus]>gi|58477496|gb|AAH89338.1| Ribosomal protein S12 [Mus musculus]>gi|58760405|gb|AAW82112.1| ribosomal protein S12 [Bos taurus]>gi|59862106|gb|AAH90257.1| Ribosomal protein S12 [Mus musculus]>gi|61363690|gb|AAX42429.1| ribosomal protein S12 [synthetic construct]>gi|61363697|gb|AAX42430.1| ribosomal protein S12 [synthetic construct]>gi|62024911|gb|AAH92044.1| Ribosomal protein S12 [Mus musculus]>gi|63100759|gb|AAH95424.1| Ribosomal protein S12 [Homo sapiens]>gi|66794609|gb|AAH96653.1| Ribosomal protein S12 [Mus musculus]>gi|68534451|gb|AAH99377.1| Ribosomal protein S12 [Mus musculus]>gi|73586911|gb|AAI02501.1| Ribosomal protein S12 [Bos taurus]>gi|74141830|dbj|BAE40986.1| unnamed protein product [Mus musculus]>gi|74185019|dbj|BAE39118.1| unnamed protein product [Mus musculus]>gi|74185141|dbj|BAE39171.1| unnamed protein product [Mus musculus]>gi|74212208|dbj|BAE40263.1| unnamed protein product [Mus musculus]>gi|119568396|gb|EAW48011.1| ribosomal protein S12, isoform CRA_d [Homo sapiens]>gi|148672821|gb|EDL04768.1| mCG6749, isoform CRA_b [Mus musculus]>gi|148679767|gb|EDL11714.1| mCG132913 [Mus musculus]>gi|149032886|gb|EDL87741.1| rCG42036, isoform CRA_b [Rattus norvegicus]>gi|189053146|dbj|BAG34768.1| unnamed protein product [Homo sapiens]>gi|288550924|gb|ADC53068.1| ribosomal protein S12 [Ailuropoda melanoleuca]>gi|296483999|tpg|DAA26114.1| TPA: 40S ribosomal protein S12 [Bos taurus]>gi|327239348|gb|AEA39541.1| ribosomal protein S12 [Ailuropoda melanoleuca]>gi|355748890|gb|EHH53373.1| hypothetical protein EGM_14005 [Macaca fascicularis]>gi|444729021|gb|ELW69452.1| 40S ribosomal protein S12 [Tupaia chinensis]>gi|530668440|gb|EQB78741.1| 40S ribosomal protein S12 [Camelus ferus]>gi|537228707|gb|ERE83698.1| 40S ribosomal protein S12-like protein [Cricetulus griseus] 92444078 BC028984.1 474 0 Homo sapiens ribosomal protein S12, mRNA (cDNA clone IMAGE:3904445) K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P25398 687 2.8e-71 40S ribosomal protein S12 OS=Homo sapiens GN=RPS12 PE=1 SV=3 -- -- GO:0042254//GO:0006413//GO:0006415//GO:0000184//GO:0019083//GO:0006614//GO:0006414 ribosome biogenesis//translational initiation//translational termination//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//viral transcription//SRP-dependent cotranslational protein targeting to membrane//translational elongation GO:0003735 structural constituent of ribosome GO:0005739//GO:0022627//GO:0005840 mitochondrion//cytosolic small ribosomal subunit//ribosome KOG3406 40S ribosomal protein S12 Cluster-7727.0 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7727.1 BF_2 2.00 1.22 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7728.0 BF_2 4.00 0.92 469 -- -- -- -- -- 1296817 X94706.1 272 1.25027e-138 Juglans nigra x Juglans regia mRNA for chalcone synthase (CHS2) -- -- -- -- P48387 650 5.3e-67 Chalcone synthase 2 OS=Camellia sinensis GN=CHS2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7729.0 BF_2 3.00 0.56 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7731.0 BF_2 12.00 2.24 511 -- -- -- -- -- 566208157 XM_002323130.2 128 1.53498e-58 Populus trichocarpa hypothetical protein (POPTR_0016s01720g) mRNA, complete cds -- -- -- -- Q00451 360 2.5e-33 36.4 kDa proline-rich protein OS=Solanum lycopersicum GN=TPRP-F1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7734.0 BF_2 3.00 0.70 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7739.0 BF_2 8.00 1.13 582 529498056 AGT02755.1 589 1.9e-58 argininosuccinate synthase [Angomonas desouzai] 115487943 NM_001072991.1 576 0 Oryza sativa Japonica Group Os12g0235800 (Os12g0235800) mRNA, complete cds K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q9SZX3 833 4.0e-88 Argininosuccinate synthase, chloroplastic OS=Arabidopsis thaliana GN=At4g24830 PE=2 SV=3 PF00764 Arginosuccinate synthase GO:0006531//GO:0006560//GO:0006526//GO:0006522 aspartate metabolic process//proline metabolic process//arginine biosynthetic process//alanine metabolic process GO:0004055//GO:0005524 argininosuccinate synthase activity//ATP binding -- -- KOG1706 Argininosuccinate synthase Cluster-7740.0 BF_2 3.00 0.34 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7741.0 BF_2 5.00 0.54 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7744.0 BF_2 8.00 5.03 349 767943408 XP_011534357.1 330 1.2e-28 PREDICTED: proto-oncogene tyrosine-protein kinase ROS isoform X8 [Homo sapiens] 584458492 NG_033929.1 349 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 330 5.0e-30 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-7745.0 BF_2 4.00 0.47 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7749.0 BF_2 8.00 1.27 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7753.0 BF_2 5.00 3.51 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7754.0 BF_2 6.00 1.03 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7755.0 BF_2 2.00 0.46 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7756.0 BF_2 10.00 1.08 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P46667 123 9.8e-06 Homeobox-leucine zipper protein ATHB-5 OS=Arabidopsis thaliana GN=ATHB-5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7759.0 BF_2 2.13 0.33 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7761.0 BF_2 3.00 0.57 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7763.0 BF_2 1.00 0.32 418 530397289 XP_005274302.1 693 1.2e-70 PREDICTED: neuroblast differentiation-associated protein AHNAK isoform X6 [Homo sapiens] 530397288 XM_005274245.1 334 3.77892e-173 PREDICTED: Homo sapiens AHNAK nucleoprotein (AHNAK), transcript variant X7, mRNA -- -- -- -- Q09666 685 4.1e-71 Neuroblast differentiation-associated protein AHNAK OS=Homo sapiens GN=AHNAK PE=1 SV=2 PF02812 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-7768.0 BF_2 7.00 0.99 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7769.0 BF_2 6.00 0.66 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7771.0 BF_2 8.00 0.82 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7776.0 BF_2 5.00 1.37 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7777.0 BF_2 1.00 0.59 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7778.0 BF_2 6.00 1.35 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7783.0 BF_2 7.00 1.18 535 193875800 ACF24536.1 347 2.0e-30 light harvesting complex protein LHCII-1 [Gymnochlora stellata] 595801649 XM_007201794.1 350 0 Prunus persica hypothetical protein (PRUPE_ppa009496mg) mRNA, complete cds -- -- -- -- Q9XF89 786 1.0e-82 Chlorophyll a-b binding protein CP26, chloroplastic OS=Arabidopsis thaliana GN=LHCB5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-7788.0 BF_2 210.00 341.87 294 -- -- -- -- -- 195594633 EU942279.1 294 4.40986e-151 Zea mays clone 1479406 mRNA sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7791.0 BF_2 4.00 1.01 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7804.0 BF_2 3.00 0.32 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7806.0 BF_2 10.00 56.66 249 -- -- -- -- -- 213876597 FJ424815.1 249 3.78094e-126 Oryza sativa Japonica Group cultivar Shangshida No. 3 Gt3 mRNA, partial cds -- -- -- -- Q09151 302 6.4e-27 Glutelin type-A 3 OS=Oryza sativa subsp. japonica GN=GLUA3 PE=2 SV=2 PF07359 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) GO:0042742 defense response to bacterium -- -- -- -- -- -- Cluster-7811.0 BF_2 8.00 1.66 488 724828822 XP_010362764.1 283 4.8e-23 PREDICTED: uncharacterized protein LOC104663322 [Rhinopithecus roxellana] 545688942 NG_027904.2 458 0 Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide (GNAQ), RefSeqGene on chromosome 9 -- -- -- -- Q2PKF4 125 4.2e-06 Guanine nucleotide-binding protein G(q) subunit alpha OS=Sus scrofa GN=GNAQ PE=2 SV=3 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0004871//GO:0019001 GTPase activity//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding -- -- -- -- Cluster-7817.0 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7817.1 BF_2 2.00 0.52 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7818.0 BF_2 2.00 0.66 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08493 Aflatoxin regulatory protein GO:0045122//GO:0006355 aflatoxin biosynthetic process//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-7819.0 BF_2 4.00 0.51 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7829.0 BF_2 9.00 1.72 506 156404264 XP_001640327.1 410 9.4e-38 predicted protein [Nematostella vectensis]>gi|156227461|gb|EDO48264.1| predicted protein [Nematostella vectensis] 695034344 XM_009406404.1 131 3.26472e-60 PREDICTED: Musa acuminata subsp. malaccensis 60S ribosomal protein L10 (LOC103987933), mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q9SPB3 562 9.2e-57 60S ribosomal protein L10 OS=Vitis riparia GN=RPL10 PE=2 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-7829.1 BF_2 3.00 4.20 301 470441553 XP_004339426.1 426 7.7e-40 ribosomal protein L10, putative [Acanthamoeba castellanii str. Neff]>gi|440796304|gb|ELR17413.1| ribosomal protein L10, putative [Acanthamoeba castellanii str. Neff] 823228514 XM_012591559.1 134 3.97584e-62 PREDICTED: Gossypium raimondii 60S ribosomal protein L10-like (LOC105770383), mRNA K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 Q9SPB3 517 8.9e-52 60S ribosomal protein L10 OS=Vitis riparia GN=RPL10 PE=2 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-7832.0 BF_2 4.00 1.08 441 556756359 XP_005973529.1 354 2.5e-31 PREDICTED: 30S ribosomal protein S11, chloroplastic-like [Pantholops hodgsonii] 761231856 KM881642.1 441 0 Oryza longistaminata isolate 81953 chloroplast, complete genome K02948 RP-S11, MRPS11, rpsK small subunit ribosomal protein S11 http://www.genome.jp/dbget-bin/www_bget?ko:K02948 P0C462 721 2.9e-75 30S ribosomal protein S11, chloroplastic OS=Oryza sativa GN=rps11 PE=3 SV=1 PF00411 Ribosomal protein S11 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-7833.0 BF_2 19.00 253.99 226 -- -- -- -- -- 38490494 BX000500.4 176 1.29289e-85 Oryza sativa chromosome 12, . BAC OSJNBb0027B07 of library OSJNBb from chromosome 12 of cultivar Nipponbare of ssp. japonica of Oryza sativa (rice), complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7834.0 BF_2 5.00 1.36 441 6093889 O61462.3 344 3.7e-30 RecName: Full=60S ribosomal protein L37a [Cryptochiton stelleri]>gi|3098458|gb|AAC15655.1| 60S ribosomal protein L37A [Cryptochiton stelleri] 347661995 BT132348.1 401 0 Oryza sativa clone RRlibD00005 mRNA sequence K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 Q5QM99 456 1.6e-44 60S ribosomal protein L37a OS=Oryza sativa subsp. japonica GN=Os01g0679700 PE=1 SV=1 PF01780//PF00130//PF06220 Ribosomal L37ae protein family//Phorbol esters/diacylglycerol binding domain (C1 domain)//U1 zinc finger GO:0042254//GO:0035556//GO:0006412 ribosome biogenesis//intracellular signal transduction//translation GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0402 60S ribosomal protein L37 Cluster-7838.0 BF_2 11.00 1.07 716 795527062 XP_011901841.1 326 7.3e-28 PREDICTED: receptor tyrosine-protein kinase erbB-2 isoform X3 [Cercocebus atys] 171906587 NG_007503.1 716 0 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), RefSeqGene on chromosome 17 K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 P04626 326 3.0e-29 Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens GN=ERBB2 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-7839.0 BF_2 14.00 2.50 521 821025871 XP_012352980.1 413 4.3e-38 PREDICTED: receptor tyrosine-protein kinase erbB-2 isoform X1 [Nomascus leucogenys] 171906587 NG_007503.1 521 0 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), RefSeqGene on chromosome 17 K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 P04626 412 2.3e-39 Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens GN=ERBB2 PE=1 SV=1 PF00757 Furin-like cysteine rich region GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0004714//GO:0005524 transmembrane receptor protein tyrosine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-7848.0 BF_2 1.00 0.33 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7850.0 BF_2 2.00 0.48 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7851.0 BF_2 14.00 0.45 1588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7856.0 BF_2 4.00 0.85 483 292618595 XP_002663718.1 343 5.3e-30 PREDICTED: bax inhibitor 1 [Danio rerio]>gi|688575733|ref|XP_009303987.1| PREDICTED: bax inhibitor 1 [Danio rerio] 743864616 XM_011033663.1 187 2.30128e-91 PREDICTED: Populus euphratica bax inhibitor 1-like (LOC105130934), mRNA -- -- -- -- Q9LD45 554 7.4e-56 Bax inhibitor 1 OS=Arabidopsis thaliana GN=BI-1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-7862.0 BF_2 4.00 0.44 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7866.0 BF_2 3.00 0.61 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7868.0 BF_2 3.00 0.33 668 499140776 AGL76355.1 333 1.1e-28 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 184 8.2e-13 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-7884.0 BF_2 6.00 0.36 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7885.0 BF_2 26.00 1.91 858 470501096 XP_004347116.1 430 7.7e-40 glycogen phosphorylase 1, putative [Acanthamoeba castellanii str. Neff]>gi|440800699|gb|ELR21734.1| glycogen phosphorylase 1, putative [Acanthamoeba castellanii str. Neff] 32973784 AK063766.1 858 0 Oryza sativa Japonica Group cDNA clone:001-121-B07, full insert sequence K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P53535 783 3.7e-82 Alpha-1,4 glucan phosphorylase L-2 isozyme, chloroplastic/amyloplastic OS=Solanum tuberosum GN=STP-1 PE=1 SV=1 PF00343 Carbohydrate phosphorylase GO:0005975 carbohydrate metabolic process GO:0008184 glycogen phosphorylase activity -- -- KOG2099 Glycogen phosphorylase Cluster-7886.0 BF_2 3.00 0.48 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7890.0 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7891.0 BF_2 10.00 5.89 354 -- -- -- -- -- 213876597 FJ424815.1 354 0 Oryza sativa Japonica Group cultivar Shangshida No. 3 Gt3 mRNA, partial cds -- -- -- -- Q09151 495 3.8e-49 Glutelin type-A 3 OS=Oryza sativa subsp. japonica GN=GLUA3 PE=2 SV=2 PF00190 Cupin -- -- GO:0045735 nutrient reservoir activity -- -- -- -- Cluster-7892.0 BF_2 5.00 2.23 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05247 Flagellar transcriptional activator (FlhD) GO:0044780//GO:0045893 bacterial-type flagellum assembly//positive regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-7894.0 BF_2 4.00 0.53 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7897.0 BF_2 3.00 0.62 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7899.0 BF_2 5.00 0.54 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7900.0 BF_2 9.00 1.52 534 674592338 CDS28856.1 181 3.6e-11 integrin linked protein kinase [Hymenolepis microstoma] 825706052 NM_001155791.2 534 0 Zea mays elongation factor 1-delta 1 (LOC100282885), mRNA K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 Q40680 377 2.7e-35 Elongation factor 1-delta 1 OS=Oryza sativa subsp. japonica GN=Os07g0614500 PE=2 SV=3 PF14630 Origin recognition complex (ORC) subunit 5 C-terminus GO:0006260 DNA replication -- -- GO:0000808//GO:0005634 origin recognition complex//nucleus KOG1668 Elongation factor 1 beta/delta chain Cluster-7901.0 BF_2 6.00 0.66 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7902.0 BF_2 1.00 3.23 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7908.0 BF_2 4.00 0.68 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7910.0 BF_2 3.00 0.65 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7911.0 BF_2 1.00 1.40 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7912.0 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7914.0 BF_2 3.00 3.14 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7915.0 BF_2 1.00 3.52 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7919.0 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7921.0 BF_2 1.00 5.48 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01797 Transposase IS200 like GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-7923.0 BF_2 9.00 0.43 1167 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7923.1 BF_2 3.00 1.64 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7925.0 BF_2 5.00 0.62 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7926.0 BF_2 11.00 1.59 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9LSF8 367 4.3e-34 Cytochrome P450 82G1 OS=Arabidopsis thaliana GN=CYP82G1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-7929.0 BF_2 26.00 1.44 1042 224028157 CAX48991.1 450 4.5e-42 water and ammonia transporting aquaporin [Lumbricus rubellus] 238814667 FJ971053.1 834 0 Juglans regia plasma intrinsic protein 1;1 mRNA, complete cds K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q08733 1270 1.5e-138 Aquaporin PIP1-3 OS=Arabidopsis thaliana GN=PIP1-3 PE=1 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-7933.0 BF_2 2.00 2.34 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9LS40 375 2.7e-35 Protein ASPARTIC PROTEASE IN GUARD CELL 1 OS=Arabidopsis thaliana GN=ASPG1 PE=1 SV=1 PF00026//PF04453 Eukaryotic aspartyl protease//Organic solvent tolerance protein GO:0061024//GO:0010033//GO:0006508 membrane organization//response to organic substance//proteolysis GO:0004190 aspartic-type endopeptidase activity GO:0019867 outer membrane -- -- Cluster-7945.0 BF_2 19.00 1.90 706 675769308 XP_008974241.1 741 5.4e-76 PREDICTED: hamartin isoform X1 [Pan paniscus]>gi|675769311|ref|XP_008974242.1| PREDICTED: hamartin isoform X1 [Pan paniscus]>gi|675769314|ref|XP_008974243.1| PREDICTED: hamartin isoform X1 [Pan paniscus] 254039583 NG_012386.1 706 0 Homo sapiens tuberous sclerosis 1 (TSC1), RefSeqGene (LRG_486) on chromosome 9 K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q92574 741 2.2e-77 Hamartin OS=Homo sapiens GN=TSC1 PE=1 SV=2 PF04382 SAB domain GO:0030866 cortical actin cytoskeleton organization GO:0008092 cytoskeletal protein binding GO:0005856 cytoskeleton -- -- Cluster-7948.0 BF_2 3.00 0.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7950.0 BF_2 3.00 0.56 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7951.0 BF_2 3.00 0.55 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7955.2 BF_2 2.00 1.36 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7956.0 BF_2 6.00 0.32 1081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7957.1 BF_2 1.00 0.91 324 767938662 XP_011532966.1 576 3.4e-57 PREDICTED: calnexin isoform X2 [Homo sapiens] 767938663 XM_011534665.1 324 1.03459e-167 PREDICTED: Homo sapiens calnexin (CANX), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P27824 576 1.4e-58 Calnexin OS=Homo sapiens GN=CANX PE=1 SV=2 PF00262 Calreticulin family GO:0006457 protein folding GO:0005509//GO:0051082 calcium ion binding//unfolded protein binding GO:0005783 endoplasmic reticulum KOG0675 Calnexin Cluster-7958.0 BF_2 6.00 2.00 412 14198259 AAH08189.1 412 4.5e-38 Unknown (protein for IMAGE:3584589), partial [Mus musculus] 590605102 XM_007020344.1 235 4.02108e-118 Theobroma cacao Heat shock protein 81.4 (TCM_030579) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 P55737 415 8.3e-40 Heat shock protein 90-2 OS=Arabidopsis thaliana GN=HSP90-2 PE=1 SV=1 PF00183 Hsp90 protein GO:0006950//GO:0006457 response to stress//protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-7958.2 BF_2 2.00 12.56 246 799541145 AKA66300.1 176 6.2e-11 heat shock protein 90, partial [Siniperca chuatsi] 190611532 EU648838.1 144 8.72377e-68 Psiguria sp. Steele 1004 clone 01 Psig57 region genomic sequence -- -- -- -- P55737 179 1.2e-12 Heat shock protein 90-2 OS=Arabidopsis thaliana GN=HSP90-2 PE=1 SV=1 PF00183 Hsp90 protein GO:0006950//GO:0006457 response to stress//protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-7963.0 BF_2 1.00 0.96 321 73921480 AAZ94270.1 255 5.6e-20 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 200 5.5e-15 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005488//GO:0016705//GO:0005506//GO:0016491//GO:0020037 binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-7965.0 BF_2 22.00 0.73 1553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7967.0 BF_2 2.00 0.42 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7968.0 BF_2 1.00 0.48 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7970.1 BF_2 2.00 0.32 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-7974.0 BF_2 4.00 0.41 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7979.1 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7981.0 BF_2 14.00 10.10 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-7982.0 BF_2 36.00 5.68 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9FK81 345 1.5e-31 Uncharacterized protein At5g22580 OS=Arabidopsis thaliana GN=At5g22580 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8000.0 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8001.0 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8002.0 BF_2 4.00 0.43 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8005.0 BF_2 14.00 2.08 569 196016205 XP_002117956.1 493 2.5e-47 hypothetical protein TRIADDRAFT_38509 [Trichoplax adhaerens]>gi|190579429|gb|EDV19524.1| hypothetical protein TRIADDRAFT_38509 [Trichoplax adhaerens] 116633647 CT833429.1 566 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCRA102P23, full insert sequence K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P48494 843 2.7e-89 Triosephosphate isomerase, cytosolic OS=Oryza sativa subsp. japonica GN=TPI PE=1 SV=3 PF00121 Triosephosphate isomerase GO:0006006//GO:0006096//GO:0008152//GO:0006020//GO:0006094//GO:0015976//GO:0046486//GO:0006000//GO:0006013 glucose metabolic process//glycolytic process//metabolic process//inositol metabolic process//gluconeogenesis//carbon utilization//glycerolipid metabolic process//fructose metabolic process//mannose metabolic process GO:0004807//GO:0016853 triose-phosphate isomerase activity//isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8007.0 BF_2 4.00 1.03 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8007.1 BF_2 6.00 0.64 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8008.0 BF_2 3.00 0.40 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8009.0 BF_2 9.00 328.86 204 -- -- -- -- -- 535242 X79685.1 106 9.37719e-47 O.sativa L. (Indica cv.IR24) U3 snRNA gene promoter -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8012.0 BF_2 2.00 0.49 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8014.0 BF_2 3.00 0.52 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8021.0 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8025.0 BF_2 2.00 0.34 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8027.0 BF_2 4.00 0.37 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8028.0 BF_2 6.00 0.72 637 607360198 EZA54533.1 362 4.3e-32 hypothetical protein X777_05512, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8030.0 BF_2 3.00 0.41 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8032.0 BF_2 18.08 1.17 934 478259957 ENN79759.1 407 3.9e-37 hypothetical protein YQE_03815, partial [Dendroctonus ponderosae]>gi|546681505|gb|ERL91582.1| hypothetical protein D910_08912 [Dendroctonus ponderosae] -- -- -- -- -- K05614 SLC1A3, EAAT1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05614 P51906 256 5.1e-21 Excitatory amino acid transporter 3 OS=Mus musculus GN=Slc1a1 PE=1 SV=2 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8034.0 BF_2 2.00 1.68 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8038.0 BF_2 5.00 0.57 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8039.0 BF_2 5.00 0.60 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8040.0 BF_2 2.00 0.44 477 225875100 CAQ86665.1 640 1.9e-64 cryptochrome [Euphausia superba] -- -- -- -- -- K02295 CRY cryptochrome http://www.genome.jp/dbget-bin/www_bget?ko:K02295 Q8WP19 535 1.2e-53 Cryptochrome-1 OS=Macaca fascicularis GN=CRY1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0133 Deoxyribodipyrimidine photolyase/cryptochrome Cluster-8044.0 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8045.0 BF_2 26.00 1.68 935 686754169 XP_009250137.1 395 9.6e-36 PREDICTED: LOW QUALITY PROTEIN: receptor tyrosine-protein kinase erbB-2 [Pongo abelii] 171906587 NG_007503.1 935 0 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), RefSeqGene on chromosome 17 K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 O18735 310 2.8e-27 Receptor tyrosine-protein kinase erbB-2 OS=Canis familiaris GN=ERBB2 PE=2 SV=1 PF00757 Furin-like cysteine rich region GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0004714//GO:0005524 transmembrane receptor protein tyrosine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8046.0 BF_2 10.00 1.59 551 780175155 XP_011661243.1 232 4.5e-17 PREDICTED: laccase-2-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q9FY79 542 2.1e-54 Laccase-14 OS=Arabidopsis thaliana GN=LAC14 PE=2 SV=1 PF07731 Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- -- -- Cluster-8051.0 BF_2 1.00 0.52 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8052.0 BF_2 6.00 1.79 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07297 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GO:0009059 macromolecule biosynthetic process -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8054.0 BF_2 1.00 0.33 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8057.0 BF_2 19.00 3.97 487 700354676 XP_009921627.1 258 3.8e-20 PREDICTED: glycine-rich RNA-binding protein GRP1A-like, partial [Haliaeetus albicilla] 195612079 EU955752.1 356 0 Zea mays clone 1544761 glycine-rich RNA-binding protein 2 mRNA, complete cds K13195 CIRBP cold-inducible RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13195 Q43472 366 4.7e-34 Glycine-rich RNA-binding protein blt801 OS=Hordeum vulgare GN=blt801 PE=1 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8058.0 BF_2 2.00 1.10 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8062.0 BF_2 7.00 0.62 760 270007709 EFA04157.1 440 4.7e-41 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 386 3.5e-36 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664 ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8065.0 BF_2 16.00 2.05 614 -- -- -- -- -- 645258909 XM_008236887.1 57 5.47835e-19 PREDICTED: Prunus mume indole-3-acetic acid-induced protein ARG2 (LOC103333976), mRNA -- -- -- -- P32292 260 1.2e-21 Indole-3-acetic acid-induced protein ARG2 OS=Vigna radiata var. radiata GN=ARG2 PE=2 SV=1 PF03242 Late embryogenesis abundant protein GO:0006950 response to stress -- -- -- -- -- -- Cluster-8067.0 BF_2 4.00 1.65 387 -- -- -- -- -- 336285187 NR_038652.1 50 2.60399e-15 Tribolium castaneum microRNA mir-3830 (Mir3830), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8069.0 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8070.0 BF_2 2.00 0.82 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8074.0 BF_2 2.00 1.01 367 821002688 XP_012364988.1 296 1.1e-24 PREDICTED: tropomyosin alpha-4 chain isoform X3 [Nomascus leucogenys] 768003739 XM_011528232.1 367 0 PREDICTED: Homo sapiens tropomyosin 4 (TPM4), transcript variant X4, mRNA K10375 TPM4 tropomyosin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10375 P02561 296 4.7e-26 Tropomyosin alpha-4 chain OS=Equus caballus GN=TPM4 PE=1 SV=2 PF07851//PF06009//PF04111//PF01544//PF01496//PF16716//PF00103//PF09730//PF10473//PF07926//PF02601//PF08702 TMPIT-like protein//Laminin Domain II//Autophagy protein Apg6//CorA-like Mg2+ transporter protein//V-type ATPase 116kDa subunit family//Bone marrow stromal antigen 2//Somatotropin hormone family//Microtubule-associated protein Bicaudal-D//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family GO:0006914//GO:0051258//GO:0006810//GO:0007165//GO:0055085//GO:0015992//GO:0006606//GO:0051607//GO:0015991//GO:0030001//GO:0006308//GO:0007155//GO:0030168 autophagy//protein polymerization//transport//signal transduction//transmembrane transport//proton transport//protein import into nucleus//defense response to virus//ATP hydrolysis coupled proton transport//metal ion transport//DNA catabolic process//cell adhesion//platelet activation GO:0045502//GO:0008134//GO:0005102//GO:0015078//GO:0008855//GO:0005179//GO:0042803//GO:0030674//GO:0046873 dynein binding//transcription factor binding//receptor binding//hydrogen ion transmembrane transporter activity//exodeoxyribonuclease VII activity//hormone activity//protein homodimerization activity//protein binding, bridging//metal ion transmembrane transporter activity GO:0005794//GO:0016021//GO:0005577//GO:0009318//GO:0005667//GO:0030286//GO:0033179//GO:0005576//GO:0016020 Golgi apparatus//integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//transcription factor complex//dynein complex//proton-transporting V-type ATPase, V0 domain//extracellular region//membrane -- -- Cluster-8076.0 BF_2 4.00 0.31 821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8077.0 BF_2 10.34 0.47 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8079.0 BF_2 3.00 0.37 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8085.0 BF_2 3.00 0.33 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8086.0 BF_2 2.00 0.44 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8087.0 BF_2 4.00 1.63 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8088.0 BF_2 4.00 0.36 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8094.0 BF_2 2.00 0.73 401 641681328 XP_008189424.1 145 4.0e-07 PREDICTED: uncharacterized protein LOC103311554, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8096.0 BF_2 10.00 1.36 595 821490993 XP_012407711.1 255 1.0e-19 PREDICTED: mast/stem cell growth factor receptor Kit [Sarcophilus harrisii] 170014706 NG_007456.1 595 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 O97799 254 5.6e-21 Mast/stem cell growth factor receptor Kit OS=Canis familiaris GN=KIT PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8103.0 BF_2 7.00 2.38 409 -- -- -- -- -- 116637418 CT828574.1 409 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCFA333Z21, full insert sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8104.1 BF_2 2.00 0.50 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8106.0 BF_2 7.00 1.05 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8107.0 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8108.0 BF_2 2.00 0.56 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8112.0 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8117.0 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8118.0 BF_2 18.00 4.79 444 221059958 XP_002260624.1 444 9.5e-42 ubiquitin [Plasmodium knowlesi strain H]>gi|193810698|emb|CAQ42596.1| ubiquitin, putative [Plasmodium knowlesi strain H] 729294838 XM_010539677.1 193 9.70994e-95 PREDICTED: Tarenaya hassleriana polyubiquitin (LOC104812493), mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CH33 454 2.7e-44 Polyubiquitin 11 OS=Arabidopsis thaliana GN=UBQ11 PE=1 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8120.0 BF_2 4.36 0.86 500 -- -- -- -- -- 23495780 AP003963.3 401 0 Oryza sativa Japonica Group genomic DNA, chromosome 7, BAC clone:OJ1779_B07 -- -- -- -- Q01882 558 2.6e-56 Seed allergenic protein RAG2 OS=Oryza sativa subsp. japonica GN=RAG2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8125.0 BF_2 11.00 1.67 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8128.0 BF_2 6.00 0.75 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8131.0 BF_2 10.00 1.59 550 557238644 CDJ61342.1 311 3.1e-26 fructose-1,6-bisphosphate aldolase, putative [Eimeria maxima] 359751824 JN208224.1 550 0 Oryza sativa Japonica Group isolate Kcb949a11 fructose-bisphosphate aldolase mRNA, complete cds K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P17784 441 1.1e-42 Fructose-bisphosphate aldolase cytoplasmic isozyme OS=Oryza sativa subsp. japonica GN=FBA PE=1 SV=2 PF00274 Fructose-bisphosphate aldolase class-I GO:0006020//GO:0006098//GO:0006096//GO:0006000//GO:0006013//GO:0015976//GO:0006094 inositol metabolic process//pentose-phosphate shunt//glycolytic process//fructose metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8132.0 BF_2 43.00 3.65 780 91084407 XP_967001.1 339 2.5e-29 PREDICTED: uncharacterized protein LOC655368 [Tribolium castaneum]>gi|270008706|gb|EFA05154.1| hypothetical protein TcasGA2_TC015272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8132.1 BF_2 80.98 5.49 904 91078702 XP_971728.1 451 3.0e-42 PREDICTED: uncharacterized protein LOC660404 [Tribolium castaneum]>gi|270003756|gb|EFA00204.1| hypothetical protein TcasGA2_TC003029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8133.0 BF_2 5.00 0.85 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8135.0 BF_2 7.00 0.66 732 33469974 NP_877962.1 616 1.8e-61 cyclic AMP-dependent transcription factor ATF-4 [Homo sapiens]>gi|33469976|ref|NP_001666.2| cyclic AMP-dependent transcription factor ATF-4 [Homo sapiens]>gi|116241262|sp|P18848.3|ATF4_HUMAN RecName: Full=Cyclic AMP-dependent transcription factor ATF-4; Short=cAMP-dependent transcription factor ATF-4; AltName: Full=Activating transcription factor 4; AltName: Full=Cyclic AMP-responsive element-binding protein 2; Short=CREB-2; Short=cAMP-responsive element-binding protein 2; AltName: Full=DNA-binding protein TAXREB67; AltName: Full=Tax-responsive enhancer element-binding protein 67; Short=TaxREB67>gi|16877178|gb|AAH16855.1| Activating transcription factor 4 (tax-responsive enhancer element B67) [Homo sapiens]>gi|18314379|gb|AAH22088.1| Activating transcription factor 4 (tax-responsive enhancer element B67) [Homo sapiens]>gi|27924377|gb|AAH44895.1| Activating transcription factor 4 (tax-responsive enhancer element B67) [Homo sapiens]>gi|47678299|emb|CAG30270.1| ATF4 [Homo sapiens]>gi|49258096|gb|AAH73754.1| Activating transcription factor 4 (tax-responsive enhancer element B67) [Homo sapiens]>gi|109451024|emb|CAK54373.1| ATF4 [synthetic construct]>gi|109451602|emb|CAK54672.1| ATF4 [synthetic construct]>gi|119580745|gb|EAW60341.1| activating transcription factor 4 (tax-responsive enhancer element B67), isoform CRA_a [Homo sapiens]>gi|119580746|gb|EAW60342.1| activating transcription factor 4 (tax-responsive enhancer element B67), isoform CRA_a [Homo sapiens]>gi|224487741|dbj|BAH24105.1| activating transcription factor 4 [synthetic construct]>gi|649098595|gb|AIC48314.1| ATF4, partial [synthetic construct] 563317857 NM_182810.2 732 0 Homo sapiens activating transcription factor 4 (ATF4), transcript variant 2, mRNA K04374 ATF4, CREB2 cyclic AMP-dependent transcription factor ATF-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04374 P18848 616 7.3e-63 Cyclic AMP-dependent transcription factor ATF-4 OS=Homo sapiens GN=ATF4 PE=1 SV=3 -- -- GO:0043525//GO:0006094//GO:0006520//GO:0045944//GO:0070059//GO:0006987 positive regulation of neuron apoptotic process//gluconeogenesis//cellular amino acid metabolic process//positive regulation of transcription from RNA polymerase II promoter//intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress//activation of signaling protein activity involved in unfolded protein response GO:0043565//GO:0003700//GO:0005515 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005737//GO:0005886//GO:0005815//GO:0005667 cytoplasm//plasma membrane//microtubule organizing center//transcription factor complex -- -- Cluster-8139.0 BF_2 10.00 0.78 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8141.0 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8143.0 BF_2 3.00 0.63 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8146.0 BF_2 1.00 0.80 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8148.0 BF_2 10.00 1.04 691 -- -- -- -- -- 731400381 XM_002276474.3 104 4.63054e-45 PREDICTED: Vitis vinifera polyadenylate-binding protein-interacting protein 2-like (LOC100248739), mRNA -- -- -- -- Q39096 402 4.5e-38 Protein EARLY RESPONSIVE TO DEHYDRATION 15 OS=Arabidopsis thaliana GN=ERD15 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8149.0 BF_2 2.00 0.47 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8151.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8152.0 BF_2 33.00 2.90 763 -- -- -- -- -- 119395179 EF122464.1 739 0 Oryza sativa (japonica cultivar-group) clone KCS337A09 glutelin mRNA, complete cds -- -- -- -- P14614 748 3.7e-78 Glutelin type-B 4 OS=Oryza sativa subsp. japonica GN=GLUB4 PE=1 SV=1 PF00190//PF03015 Cupin//Male sterility protein -- -- GO:0045735//GO:0080019 nutrient reservoir activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8153.0 BF_2 7.00 1.81 449 -- -- -- -- -- 40794996 AY506529.1 366 0 Zea mays strain NB mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8154.0 BF_2 2.00 0.39 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8161.0 BF_2 1.00 0.45 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8162.0 BF_2 7.00 0.87 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8163.0 BF_2 11.00 3.08 436 470647546 XP_004327488.1 500 3.0e-48 PREDICTED: ALK tyrosine kinase receptor-like [Tursiops truncatus] 221554531 NG_009445.1 436 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 488 3.0e-48 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8167.0 BF_2 8.00 1.52 507 -- -- -- -- -- 255550384 XM_002516197.1 34 2.7338e-06 Ricinus communis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8168.0 BF_2 3.00 0.41 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8169.0 BF_2 8.52 3.00 405 700354676 XP_009921627.1 277 2.0e-22 PREDICTED: glycine-rich RNA-binding protein GRP1A-like, partial [Haliaeetus albicilla] 385718873 JF969238.1 350 0 Oryza sativa clone KCB741C11 Glycin-rich RNA binding protein mRNA, complete cds K13195 CIRBP cold-inducible RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13195 P49310 391 4.9e-37 Glycine-rich RNA-binding protein GRP1A OS=Sinapis alba PE=2 SV=1 PF00076//PF16367//PF03325 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Herpesvirus polymerase accessory protein GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0030337//GO:0003676 DNA polymerase processivity factor activity//nucleic acid binding GO:0042575 DNA polymerase complex -- -- Cluster-8171.0 BF_2 1.00 0.58 355 270004778 EFA01226.1 188 3.6e-12 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 151 2.9e-09 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8175.0 BF_2 6.00 2.40 390 115504283 XP_001218934.1 227 1.2e-16 alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|115504287|ref|XP_001218936.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|115504291|ref|XP_001218938.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|115504295|ref|XP_001218940.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|787997272|ref|XP_011771396.1| alpha tubulin [Trypanosoma brucei gambiense DAL972]>gi|135440|sp|P04106.1|TBA_TRYBR RecName: Full=Tubulin alpha chain>gi|162320|gb|AAA30262.1| alpha tubulin [Trypanosoma brucei]>gi|83642416|emb|CAJ16360.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|83642418|emb|CAJ16362.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|83642420|emb|CAJ16364.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|83642422|emb|CAJ16366.1| alpha tubulin [Trypanosoma brucei brucei TREU927]>gi|261326129|emb|CBH08955.1| alpha tubulin [Trypanosoma brucei gambiense DAL972]>gi|343476780|emb|CCD12219.1| unnamed protein product [Trypanosoma congolense IL3000] 385717687 JN944368.1 390 0 Oryza sativa Japonica Group clone KCS185G04 alpha-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q53M52 237 3.4e-19 Tubulin alpha-2 chain OS=Oryza sativa subsp. japonica GN=TUBA PE=2 SV=1 -- -- GO:0051258//GO:0007018//GO:0006184 protein polymerization//microtubule-based movement//obsolete GTP catabolic process GO:0005198//GO:0003924//GO:0005525 structural molecule activity//GTPase activity//GTP binding GO:0005874//GO:0005737 microtubule//cytoplasm KOG1376 Alpha tubulin Cluster-8178.0 BF_2 160.00 4.92 1647 -- -- -- -- -- 4126686 AB016501.1 1631 0 Oryza sativa mRNA for glutelin, complete cds, clone:lambda RG55 -- -- -- -- P07728 1170 9.4e-127 Glutelin type-A 1 OS=Oryza sativa subsp. japonica GN=GLUA1 PE=1 SV=2 PF00190//PF03079 Cupin//ARD/ARD' family GO:0055114 oxidation-reduction process GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity -- -- -- -- Cluster-8179.0 BF_2 4.00 0.67 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8183.0 BF_2 2.00 0.33 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8186.0 BF_2 4.00 0.55 592 861605262 KMQ84328.1 143 1.0e-06 reverse transcriptase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04006 Mpp10 protein GO:0006364 rRNA processing -- -- GO:0005634//GO:0005732//GO:0034457 nucleus//small nucleolar ribonucleoprotein complex//Mpp10 complex -- -- Cluster-8187.0 BF_2 2.00 0.32 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8189.2 BF_2 2.00 0.34 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8198.0 BF_2 5.00 1.18 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8199.0 BF_2 1.03 0.36 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8201.0 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8203.0 BF_2 7.00 1.90 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8204.0 BF_2 12.00 1.28 678 801385529 XP_012056031.1 206 5.7e-14 PREDICTED: aquaporin AQPAn.G [Atta cephalotes] 238814673 FJ971056.1 362 0 Juglans regia plasma intrinsic protein 2;3 mRNA, complete cds K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q84RL7 499 2.5e-49 Aquaporin PIP2-1 OS=Zea mays GN=PIP2-1 PE=1 SV=2 PF15683//PF08496//PF00230 Testis development-related protein//Peptidase family S49 N-terminal//Major intrinsic protein GO:0007283//GO:0006810 spermatogenesis//transport GO:0005215//GO:0004252 transporter activity//serine-type endopeptidase activity GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8205.0 BF_2 2.00 0.72 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8207.0 BF_2 6.00 5.38 325 820145772 KKX13551.1 478 7.9e-46 eukaryotic translation elongation factor 2b [Scleropages formosus] 119395215 EF122482.1 325 2.88644e-168 Oryza sativa (japonica cultivar-group) clone KCS059F08 elongation factor 2 mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 O23755 547 3.2e-55 Elongation factor 2 OS=Beta vulgaris PE=2 SV=1 PF03764 Elongation factor G, domain IV -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8212.1 BF_2 1.00 0.59 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8217.0 BF_2 4.00 0.34 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8219.0 BF_2 4.00 0.49 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8233.0 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8238.0 BF_2 2.00 0.76 396 635040021 XP_007995529.1 421 3.9e-39 PREDICTED: 40S ribosomal protein S26-like [Chlorocebus sabaeus] 694958610 XM_009428753.1 396 0 PREDICTED: Pan troglodytes 40S ribosomal protein S26 (LOC736018), mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P62856 416 6.1e-40 40S ribosomal protein S26 OS=Rattus norvegicus GN=Rps26 PE=3 SV=3 PF01283 Ribosomal protein S26e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1768 40s ribosomal protein S26 Cluster-8239.0 BF_2 3.00 1.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8242.0 BF_2 2.00 0.53 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8250.0 BF_2 3.00 0.54 519 852768879 XP_012878506.1 731 5.8e-75 PREDICTED: transmembrane emp24 domain-containing protein 2 [Dipodomys ordii] 118200338 NM_006815.3 519 0 Homo sapiens transmembrane emp24 domain trafficking protein 2 (TMED2), mRNA -- -- -- -- Q63524 731 2.4e-76 Transmembrane emp24 domain-containing protein 2 OS=Rattus norvegicus GN=Tmed2 PE=1 SV=1 PF00876//PF02342//PF01105 Innexin//TerD domain//emp24/gp25L/p24 family/GOLD GO:0006810//GO:0006950 transport//response to stress -- -- GO:0016021//GO:0005921 integral component of membrane//gap junction KOG1692 Putative cargo transport protein EMP24 (p24 protein family) Cluster-8251.0 BF_2 4.00 6.66 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9LMA8 198 8.5e-15 Protein TIFY 10A OS=Arabidopsis thaliana GN=TIFY10A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8253.0 BF_2 1.00 2.01 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8254.0 BF_2 2.00 0.82 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8255.1 BF_2 3.00 1.22 388 297297830 XP_002805090.1 138 2.5e-06 PREDICTED: hypothetical protein LOC100427867 [Macaca mulatta] 767958029 XM_011518911.1 388 0 PREDICTED: Homo sapiens SET nuclear proto-oncogene (SET), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8256.0 BF_2 45.00 1.80 1333 873232530 CEM04838.1 1077 1.1e-114 unnamed protein product [Vitrella brassicaformis CCMP3155] 764530493 XM_004290255.2 711 0 PREDICTED: Fragaria vesca subsp. vesca fructose-bisphosphate aldolase 1, chloroplastic (LOC101299626), mRNA K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 Q944G9 1761 2.2e-195 Probable fructose-bisphosphate aldolase 2, chloroplastic OS=Arabidopsis thaliana GN=FBA2 PE=1 SV=2 PF00274//PF12937 Fructose-bisphosphate aldolase class-I//F-box-like GO:0006000//GO:0006013//GO:0015976//GO:0006094//GO:0006020//GO:0006098//GO:0006096 fructose metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis//inositol metabolic process//pentose-phosphate shunt//glycolytic process GO:0005515//GO:0004332 protein binding//fructose-bisphosphate aldolase activity -- -- -- -- Cluster-8257.0 BF_2 9.00 4.65 365 767950690 XP_011542754.1 439 2.9e-41 PREDICTED: fibroblast growth factor receptor 1 isoform X15 [Homo sapiens] 188219627 NG_007729.1 365 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q91743 130 8.2e-07 Fibroblast growth factor receptor 4 OS=Xenopus laevis GN=fgfr4 PE=2 SV=1 PF06049 Coagulation Factor V LSPD Repeat GO:0007596 blood coagulation -- -- -- -- -- -- Cluster-8258.0 BF_2 13.00 1.55 637 749157223 XP_011130240.1 230 8.8e-17 UDP-glucosyltransferase [Gregarina niphandrodes]>gi|608674092|gb|EZG67407.1| UDP-glucosyltransferase [Gregarina niphandrodes] 694322543 XM_009354114.1 40 1.60615e-09 PREDICTED: Pyrus x bretschneideri hydroquinone glucosyltransferase-like (LOC103943767), transcript variant X1, mRNA >gnl|BL_ORD_ID|24655941 PREDICTED: Pyrus x bretschneideri hydroquinone glucosyltransferase-like (LOC103943767), transcript variant X2, mRNA -- -- -- -- Q9AR73 767 2.0e-80 Hydroquinone glucosyltransferase OS=Rauvolfia serpentina GN=AS PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8259.0 BF_2 5.00 0.71 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8260.0 BF_2 1.00 0.34 408 767880050 XP_011513308.1 392 9.2e-36 PREDICTED: histone-lysine N-methyltransferase 2C-like [Homo sapiens] 392996990 AC246784.2 405 0 Homo sapiens BAC clone CH17-70N6 from chromosome 1, complete sequence K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8BRH4 360 2.0e-33 Histone-lysine N-methyltransferase 2C OS=Mus musculus GN=Kmt2c PE=1 SV=2 PF07649//PF00628//PF00130 C1-like domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0047134 protein binding//protein-disulfide reductase activity -- -- -- -- Cluster-8262.0 BF_2 1.00 0.99 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8268.0 BF_2 3.00 1.42 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8269.0 BF_2 3.00 0.76 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8276.0 BF_2 13.00 1.19 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- B9RPM3 603 2.4e-61 Probable terpene synthase 9 OS=Ricinus communis GN=TPS9 PE=3 SV=1 PF03936 Terpene synthase family, metal binding domain -- -- GO:0000287//GO:0016829//GO:0010333 magnesium ion binding//lyase activity//terpene synthase activity -- -- -- -- Cluster-8278.0 BF_2 5.00 1.20 461 817285471 XP_012312993.1 680 4.2e-69 PREDICTED: 60S ribosomal protein L26 isoform X1 [Aotus nancymaae] 164697537 AK311804.1 461 0 Homo sapiens cDNA, FLJ92065, Homo sapiens ribosomal protein L26 (RPL26), mRNA K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61256 647 1.2e-66 60S ribosomal protein L26 OS=Macaca fascicularis GN=RPL26 PE=2 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG3401 60S ribosomal protein L26 Cluster-8279.0 BF_2 4.00 0.70 525 826274068 XP_012521020.1 790 8.4e-82 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [Propithecus coquereli]>gi|826274071|ref|XP_012521021.1| PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial isoform X2 [Propithecus coquereli] 767968239 XM_011545053.1 525 0 PREDICTED: Homo sapiens NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (NDUFS8), transcript variant X3, mRNA K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 P0CB98 790 3.5e-83 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Pongo pygmaeus GN=NDUFS8 PE=2 SV=1 PF05187//PF08782 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S//c-SKI Smad4 binding domain GO:0055114 oxidation-reduction process GO:0046332//GO:0004174 SMAD binding//electron-transferring-flavoprotein dehydrogenase activity -- -- KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit Cluster-8280.0 BF_2 35.00 5.29 564 -- -- -- -- -- 119394867 EF122459.1 561 0 Oryza sativa (japonica cultivar-group) clone KCS349H11 glutelin mRNA, complete cds -- -- -- -- Q09151 768 1.3e-80 Glutelin type-A 3 OS=Oryza sativa subsp. japonica GN=GLUA3 PE=2 SV=2 PF00190 Cupin -- -- GO:0045735 nutrient reservoir activity -- -- -- -- Cluster-8284.0 BF_2 8.00 5.23 346 375073649 AFA34383.1 521 8.7e-51 ribosomal protein L37 [Ostrea edulis] 675710638 XM_003810973.2 346 6.55674e-180 PREDICTED: Pan paniscus ribosomal protein L37 (RPL37), mRNA K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 P79244 489 1.8e-48 60S ribosomal protein L37 OS=Bos taurus GN=RPL37 PE=3 SV=4 PF01155//PF04060//PF01907 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Putative Fe-S cluster//Ribosomal protein L37e GO:0042254//GO:0006464//GO:0006412 ribosome biogenesis//cellular protein modification process//translation GO:0051536//GO:0003735//GO:0016151 iron-sulfur cluster binding//structural constituent of ribosome//nickel cation binding GO:0005840//GO:0005622 ribosome//intracellular KOG3475 60S ribosomal protein L37 Cluster-8286.0 BF_2 3.00 0.98 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8289.0 BF_2 3.00 0.40 600 546674505 ERL85870.1 208 3.0e-14 hypothetical protein D910_03285 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8292.0 BF_2 8.00 5.69 340 194318456 ACF47616.1 346 1.7e-30 soluble MET variant 14 [Homo sapiens] 212720875 NG_008996.1 340 1.39208e-176 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 P08581 332 2.9e-30 Hepatocyte growth factor receptor OS=Homo sapiens GN=MET PE=1 SV=4 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8295.0 BF_2 6.00 0.46 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8304.0 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8305.0 BF_2 5.00 0.89 521 724929075 XP_010382934.1 508 4.2e-49 PREDICTED: eukaryotic translation initiation factor 1A [Rhinopithecus roxellana] 645247434 XM_008231613.1 268 2.33613e-136 PREDICTED: Prunus mume eukaryotic translation initiation factor 1A (LOC103329184), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P56331 509 1.3e-50 Eukaryotic translation initiation factor 1A OS=Onobrychis viciifolia PE=2 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8306.0 BF_2 6.00 0.53 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.100 BF_2 5.00 0.37 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10001 BF_2 13.00 0.72 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00895 ATP synthase protein 8 GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.10006 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10012 BF_2 9.34 0.76 800 642928718 XP_008199753.1 572 2.4e-56 PREDICTED: fatty acid 2-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R4P4 225 1.7e-17 Fatty acid 2-hydroxylase OS=Macaca fascicularis GN=FA2H PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0539 Sphingolipid fatty acid hydroxylase Cluster-8309.10019 BF_2 34.00 5.83 531 795023802 XP_011861061.1 513 1.1e-49 PREDICTED: 60S ribosomal protein L27a [Vollenhovia emeryi] 172051103 EU574820.1 116 7.47582e-52 Ornithodoros coriaceus clone OC-240 60s ribosomal protein L15/L27 mRNA, complete cds K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 P18445 475 1.2e-46 60S ribosomal protein L27a OS=Rattus norvegicus GN=Rpl27a PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1742 60s ribosomal protein L15/L27 Cluster-8309.10031 BF_2 5.00 0.31 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10032 BF_2 9.00 1.45 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10033 BF_2 45.66 0.86 2503 149588984 NP_001092297.1 1410 5.2e-153 beta-N-acetylglucosaminidase NAG3 precursor [Tribolium castaneum]>gi|148611480|gb|ABQ95984.1| beta-N-acetylglucosaminidase NAG3 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 959 4.2e-102 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0003824 hydrolase activity, hydrolyzing O-glycosyl compounds//catalytic activity -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.10036 BF_2 5.78 0.35 985 642919236 XP_008191788.1 651 2.1e-65 PREDICTED: coiled-coil domain-containing protein 134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6E4 291 4.8e-25 Coiled-coil domain-containing protein 134 OS=Homo sapiens GN=CCDC134 PE=1 SV=1 PF03059 Nicotianamine synthase protein GO:0030418 nicotianamine biosynthetic process GO:0030410 nicotianamine synthase activity -- -- -- -- Cluster-8309.10038 BF_2 18.00 2.32 612 270009685 EFA06133.1 261 2.2e-20 hypothetical protein TcasGA2_TC008976 [Tribolium castaneum] -- -- -- -- -- K08117 APLP2 amyloid beta (A4) precursor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08117 Q7TQN3 177 4.9e-12 WAP, Kazal, immunoglobulin, Kunitz and NTR domain-containing protein 2 OS=Mus musculus GN=Wfikkn2 PE=1 SV=2 PF00014//PF00892 Kunitz/Bovine pancreatic trypsin inhibitor domain//EamA-like transporter family -- -- GO:0004867 serine-type endopeptidase inhibitor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.10041 BF_2 406.00 20.89 1100 91095049 XP_972102.1 475 5.9e-45 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 258 3.6e-21 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10059 BF_2 22.00 0.52 2072 642915340 XP_008190579.1 1474 1.6e-160 PREDICTED: adenosine deaminase CECR1-A-like [Tribolium castaneum]>gi|270003891|gb|EFA00339.1| hypothetical protein TcasGA2_TC003178 [Tribolium castaneum] -- -- -- -- -- K19572 CECR1, ADA2 adenosine deaminase CECR1 http://www.genome.jp/dbget-bin/www_bget?ko:K19572 P15287 924 4.0e-98 Adenosine deaminase AGSA OS=Aplysia californica PE=1 SV=2 PF08451//PF00962 Adenosine/AMP deaminase N-terminal//Adenosine/AMP deaminase -- -- GO:0019239 deaminase activity GO:0005615 extracellular space -- -- Cluster-8309.10063 BF_2 18.00 0.67 1408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF16331//PF06160//PF07716//PF06005//PF09730//PF01176 Septum formation initiator//TolA binding protein trimerisation//Septation ring formation regulator, EzrA//Basic region leucine zipper//Protein of unknown function (DUF904)//Microtubule-associated protein Bicaudal-D//Translation initiation factor 1A / IF-1 GO:0006810//GO:0070206//GO:0007049//GO:0006355//GO:0000921//GO:0006446//GO:0000917//GO:0043093//GO:0006413 transport//protein trimerization//cell cycle//regulation of transcription, DNA-templated//septin ring assembly//regulation of translational initiation//barrier septum assembly//FtsZ-dependent cytokinesis//translational initiation GO:0003743//GO:0003700//GO:0043565//GO:0003723 translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//RNA binding GO:0005940//GO:0005794//GO:0016021//GO:0005737//GO:0005840//GO:0005667 septin ring//Golgi apparatus//integral component of membrane//cytoplasm//ribosome//transcription factor complex -- -- Cluster-8309.10064 BF_2 231.00 3.96 2726 91091892 XP_970427.1 1227 9.3e-132 PREDICTED: uncharacterized protein C9orf114 homolog [Tribolium castaneum]>gi|270001126|gb|EEZ97573.1| hypothetical protein TcasGA2_TC011435 [Tribolium castaneum] -- -- -- -- -- K09142 K09142 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K09142 Q3UHX9 886 1.3e-93 Putative methyltransferase C9orf114 homolog OS=Mus musculus GN=D2Wsu81e PE=2 SV=1 PF00076//PF00588 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//SpoU rRNA Methylase family GO:0006396//GO:0009451 RNA processing//RNA modification GO:0008173//GO:0003723//GO:0003676 RNA methyltransferase activity//RNA binding//nucleic acid binding -- -- KOG3925 Uncharacterized conserved protein Cluster-8309.10067 BF_2 14.51 0.38 1883 546677765 ERL88544.1 269 7.9e-21 hypothetical protein D910_05929 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VYY9 180 6.8e-12 Ecotropic viral integration site 5 ortholog OS=Drosophila melanogaster GN=Evi5 PE=1 SV=3 PF04977//PF09749//PF00998//PF07716 Septum formation initiator//Uncharacterised conserved protein//Viral RNA dependent RNA polymerase//Basic region leucine zipper GO:0039694//GO:0006355//GO:0034477//GO:0007049//GO:0006144 viral RNA genome replication//regulation of transcription, DNA-templated//U6 snRNA 3'-end processing//cell cycle//purine nucleobase metabolic process GO:0003968//GO:0043565//GO:0003700//GO:0004518//GO:0003723 RNA-directed RNA polymerase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//nuclease activity//RNA binding GO:0031379//GO:0005667 RNA-directed RNA polymerase complex//transcription factor complex -- -- Cluster-8309.10071 BF_2 33.00 0.35 4227 546684200 ERL93905.1 589 1.4e-57 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm -- -- Cluster-8309.10087 BF_2 147.03 1.28 5110 91086147 XP_969343.1 2917 0.0e+00 PREDICTED: integrator complex subunit 11 [Tribolium castaneum]>gi|270009886|gb|EFA06334.1| hypothetical protein TcasGA2_TC009205 [Tribolium castaneum] 826440986 XM_012674849.1 377 0 PREDICTED: Monomorium pharaonis integrator complex subunit 11 (LOC105833262), transcript variant X4, mRNA K13148 CPSF3L, INTS11 integrator complex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13148 Q5ZIH0 2284 2.0e-255 Integrator complex subunit 11 OS=Gallus gallus GN=CPSF3L PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.10102 BF_2 1.00 0.67 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10119 BF_2 34.00 0.47 3324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10121 BF_2 17.00 0.75 1238 675883262 XP_009027133.1 471 1.9e-44 hypothetical protein HELRODRAFT_193782 [Helobdella robusta]>gi|555691541|gb|ESN94773.1| hypothetical protein HELRODRAFT_193782 [Helobdella robusta] -- -- -- -- -- K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q9TSM6 421 5.0e-40 Protein tyrosine phosphatase type IVA 1 OS=Macaca fascicularis GN=PTP4A1 PE=1 SV=1 PF00782//PF00102//PF05706 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.10128 BF_2 39.00 3.34 776 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07359 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) GO:0042742 defense response to bacterium -- -- -- -- -- -- Cluster-8309.10140 BF_2 5.00 1.08 480 148693644 EDL25591.1 394 6.4e-36 mCG10725, isoform CRA_b, partial [Mus musculus] 14591916 NM_001028.2 474 0 Homo sapiens ribosomal protein S25 (RPS25), mRNA K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q6Q311 372 9.4e-35 40S ribosomal protein S25 OS=Ovis aries GN=RPS25 PE=2 SV=1 PF01325 Iron dependent repressor, N-terminal DNA binding domain -- -- GO:0003677 DNA binding -- -- KOG1767 40S ribosomal protein S25 Cluster-8309.10141 BF_2 1.00 3.98 260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10142 BF_2 253.00 10.74 1273 478254891 ENN75126.1 159 3.0e-08 hypothetical protein YQE_08306, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11411//PF08529 DNA ligase IV//NusA N-terminal domain GO:0006260//GO:0031554//GO:0006281 DNA replication//regulation of DNA-templated transcription, termination//DNA repair GO:0003910//GO:0003700 DNA ligase (ATP) activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.10143 BF_2 29.60 0.43 3176 642932971 XP_008197211.1 598 9.4e-59 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 749745516 XM_011157000.1 146 9.93234e-68 PREDICTED: Harpegnathos saltator potassium voltage-gated channel protein Shaw-like (LOC105192704), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 483 8.4e-47 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.10150 BF_2 21.62 0.44 2327 91087271 XP_975540.1 2035 1.6e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 2.7e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.10155 BF_2 30.00 0.45 3061 218683228 ACL00655.1 4172 0.0e+00 trehalose 6-phosphate synthase 1 isoform 1 [Callinectes sapidus] 218683225 EU910086.1 2371 0 Callinectes sapidus trehalose 6-phosphate synthase 1 (TPS1) mRNA, complete cds K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 985 5.0e-105 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF00982//PF02358 Glycosyltransferase family 20//Trehalose-phosphatase GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.10157 BF_2 1.00 4.10 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10159 BF_2 138.00 6.11 1232 478255837 ENN76045.1 142 2.7e-06 hypothetical protein YQE_07418, partial [Dendroctonus ponderosae]>gi|546680469|gb|ERL90735.1| hypothetical protein D910_08082 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10173 BF_2 203.20 4.01 2407 642929118 XP_008195696.1 877 3.2e-91 PREDICTED: uncharacterized protein LOC100142378 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4PZA2 630 5.7e-64 Endothelin-converting enzyme 1 OS=Mus musculus GN=Ece1 PE=1 SV=1 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.1018 BF_2 3.00 0.36 638 512393276 AGO02163.1 1052 4.3e-112 trypsin-like serine proteinase [Scylla paramamosain] 512393275 KC757380.1 499 0 Scylla paramamosain trypsin-like serine proteinase mRNA, complete cds K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P00765 646 2.1e-66 Trypsin-1 OS=Astacus astacus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.10182 BF_2 125.85 1.26 4463 478250336 ENN70833.1 2137 4.6e-237 hypothetical protein YQE_12497, partial [Dendroctonus ponderosae] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 837 1.0e-87 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0241 Kinesin-like protein Cluster-8309.10185 BF_2 6.00 0.36 988 766940373 XP_011502781.1 335 9.2e-29 PREDICTED: equilibrative nucleoside transporter 1 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- Q99808 161 5.7e-10 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.10186 BF_2 2.00 0.92 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF00537 Arthropod defensin//Scorpion toxin-like domain GO:0006952//GO:0006810 defense response//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.1019 BF_2 16.00 1.24 826 849976741 AKN46052.1 1192 3.2e-128 trypsin-like serine proteinase [Eriocheir sinensis] 122003893 EF120995.1 286 3.74583e-146 Portunus pelagicus trypsin-like (TRY3) mRNA, partial sequence K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P00765 745 9.0e-78 Trypsin-1 OS=Astacus astacus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.10190 BF_2 75.00 1.46 2439 380003230 AFD28290.1 1252 1.1e-134 14-3-3-like protein [Eriocheir sinensis]>gi|401816688|gb|AFQ20813.1| 14-3-3 [Portunus trituberculatus] 401816687 JX138966.1 2203 0 Portunus trituberculatus 14-3-3 mRNA, complete cds K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 1127 1.4e-121 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF06386//PF02154 Gas vesicle synthesis protein GvpL/GvpF//Flagellar motor switch protein FliM GO:0071973//GO:0031412 bacterial-type flagellum-dependent cell motility//gas vesicle organization GO:0003774 motor activity GO:0009425//GO:0031411 bacterial-type flagellum basal body//gas vesicle KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.10192 BF_2 69.00 0.73 4227 262401017 ACY66411.1 1562 2.1e-170 map kinase-interacting serine/threonine [Scylla paramamosain] 262401016 FJ774689.1 868 0 Scylla paramamosain map kinase-interacting serine/threonine mRNA, partial cds K04372 MKNK, MNK MAP kinase interacting serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04372 Q66I46 1186 3.4e-128 MAP kinase-interacting serine/threonine-protein kinase 2 OS=Xenopus tropicalis GN=mknk2 PE=2 SV=1 PF00075//PF01186//PF07714//PF00069//PF06293 RNase H//Lysyl oxidase//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0051252//GO:0055114 protein phosphorylation//regulation of RNA metabolic process//oxidation-reduction process GO:0005507//GO:0005524//GO:0016641//GO:0003676//GO:0016773//GO:0004672//GO:0004523 copper ion binding//ATP binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//RNA-DNA hybrid ribonuclease activity GO:0016020 membrane KOG0607 MAP kinase-interacting kinase and related serine/threonine protein kinases Cluster-8309.10193 BF_2 65.00 1.73 1859 356713486 AET36897.1 617 3.4e-61 troponin C2 [Litopenaeus vannamei] 239949538 FJ790223.1 216 7.05501e-107 Homarus americanus troponin C isoform 4' mRNA, complete cds K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P06708 524 8.6e-52 Troponin C, isotype gamma OS=Astacus leptodactylus PE=1 SV=1 PF02337//PF03874//PF00036//PF13202//PF13499//PF10591//PF13833//PF13405//PF12763//PF02881 Retroviral GAG p10 protein//RNA polymerase Rpb4//EF hand//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand//SRP54-type protein, helical bundle domain GO:0006351//GO:0006614//GO:0007165//GO:0006144//GO:0006206 transcription, DNA-templated//SRP-dependent cotranslational protein targeting to membrane//signal transduction//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0005198//GO:0005515//GO:0005509//GO:0005525 DNA-directed RNA polymerase activity//structural molecule activity//protein binding//calcium ion binding//GTP binding GO:0019028//GO:0005578//GO:0005730 viral capsid//proteinaceous extracellular matrix//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.10194 BF_2 14.16 0.43 1667 414448013 AFW99837.1 533 1.7e-51 troponin I [Litopenaeus vannamei] 414448012 JX683728.1 293 9.91125e-150 Litopenaeus vannamei clone TPNi1 troponin I mRNA, complete cds -- -- -- -- P05547 521 1.7e-51 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.10195 BF_2 21.10 0.80 1388 414448013 AFW99837.1 533 1.4e-51 troponin I [Litopenaeus vannamei] 414448012 JX683728.1 293 8.21687e-150 Litopenaeus vannamei clone TPNi1 troponin I mRNA, complete cds -- -- -- -- P05547 521 1.4e-51 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992//PF02724//PF02601 Troponin//CDC45-like protein//Exonuclease VII, large subunit GO:0006270//GO:0006308 DNA replication initiation//DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0005861//GO:0009318 troponin complex//exodeoxyribonuclease VII complex KOG3977 Troponin I Cluster-8309.10199 BF_2 303.03 10.31 1517 170052299 XP_001862159.1 235 5.5e-17 conserved hypothetical protein [Culex quinquefasciatus]>gi|167873184|gb|EDS36567.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02386 Cation transport protein GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.10201 BF_2 21.69 0.64 1694 170052299 XP_001862159.1 235 6.2e-17 conserved hypothetical protein [Culex quinquefasciatus]>gi|167873184|gb|EDS36567.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00737//PF02386 Photosystem II 10 kDa phosphoprotein//Cation transport protein GO:0050821//GO:0055085//GO:0015979//GO:0006812 protein stabilization//transmembrane transport//photosynthesis//cation transport GO:0042301//GO:0008324 phosphate ion binding//cation transmembrane transporter activity GO:0016020//GO:0009523 membrane//photosystem II -- -- Cluster-8309.10204 BF_2 23.08 0.40 2710 642930236 XP_008196311.1 335 2.5e-28 PREDICTED: poly [ADP-ribose] polymerase 12-like isoform X1 [Tribolium castaneum]>gi|270009442|gb|EFA05890.1| hypothetical protein TcasGA2_TC008702 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZ20 163 9.1e-10 Poly [ADP-ribose] polymerase 12 OS=Mus musculus GN=Parp12 PE=2 SV=3 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- -- -- Cluster-8309.10205 BF_2 46.26 1.08 2072 554523146 XP_005856469.1 677 4.2e-68 PREDICTED: putative uncharacterized zinc finger protein 814-like isoform X1 [Myotis brandtii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 663 7.3e-68 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF13912//PF07776//PF01426//PF13465//PF00096//PF00130 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//BAH domain//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0046872//GO:0003682//GO:0008270 metal ion binding//chromatin binding//zinc ion binding GO:0000785//GO:0005634 chromatin//nucleus -- -- Cluster-8309.10218 BF_2 30.94 0.45 3172 861626561 KMQ88832.1 811 1.9e-83 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF03184 helix-turn-helix, Psq domain//DDE superfamily endonuclease -- -- GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.10229 BF_2 11.66 0.36 1656 642932333 XP_008197070.1 161 2.3e-08 PREDICTED: uncharacterized protein LOC103314052 [Tribolium castaneum]>gi|270011613|gb|EFA08061.1| hypothetical protein TcasGA2_TC005657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.1023 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10238 BF_2 7.57 0.44 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10240 BF_2 7.00 0.35 1114 575878323 AHH02588.1 268 6.1e-21 chitin-binding protein [Holotrichia parallela] -- -- -- -- -- -- -- -- -- Q9W5U2 150 1.2e-08 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607//PF01036 Chitin binding Peritrophin-A domain//Bacteriorhodopsin-like protein GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.10241 BF_2 5.00 0.66 606 270297198 NP_001161920.1 324 1.1e-27 peritrophic matrix protein 2-B precursor [Tribolium castaneum]>gi|268309034|gb|ACY95483.1| peritrophic matrix protein 2-B [Tribolium castaneum]>gi|270003976|gb|EFA00424.1| hypothetical protein TcasGA2_TC003275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W5U2 140 9.5e-08 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607//PF02891 Chitin binding Peritrophin-A domain//MIZ/SP-RING zinc finger GO:0006030 chitin metabolic process GO:0008061//GO:0008270 chitin binding//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.10242 BF_2 1.00 13.93 225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.10258 BF_2 13.00 0.51 1356 91079768 XP_966889.1 160 2.5e-08 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0008152 metabolic process -- -- -- -- -- -- Cluster-8309.10259 BF_2 149.00 4.16 1786 91077948 XP_966879.1 705 2.1e-71 PREDICTED: ribosome-recycling factor, mitochondrial [Tribolium castaneum]>gi|270002287|gb|EEZ98734.1| hypothetical protein TcasGA2_TC001287 [Tribolium castaneum] -- -- -- -- -- K02838 frr, MRRF, RRF ribosome recycling factor http://www.genome.jp/dbget-bin/www_bget?ko:K02838 Q0VCQ4 386 8.3e-36 Ribosome-recycling factor, mitochondrial OS=Bos taurus GN=MRRF PE=2 SV=1 PF01434 Peptidase family M41 GO:0006412//GO:0006508 translation//proteolysis GO:0004222//GO:0005524 metalloendopeptidase activity//ATP binding GO:0005739 mitochondrion KOG4759 Ribosome recycling factor Cluster-8309.10261 BF_2 2.00 0.73 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10265 BF_2 2.00 0.44 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07425 Pardaxin -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.10266 BF_2 1.00 2.27 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10270 BF_2 37.00 0.89 2020 91089769 XP_967094.1 1217 1.0e-130 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 579 3.9e-58 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.10272 BF_2 98.00 1.21 3671 645029280 XP_008210572.1 717 1.7e-72 PREDICTED: uncharacterized protein LOC100680378 isoform X1 [Nasonia vitripennis]>gi|645029283|ref|XP_008210573.1| PREDICTED: uncharacterized protein LOC100680378 isoform X1 [Nasonia vitripennis] 462310482 APGK01047306.1 59 2.65253e-19 Dendroctonus ponderosae Seq01047316, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF15549//PF02684 PGC7/Stella/Dppa3 domain//Lipid-A-disaccharide synthetase GO:0009245 lipid A biosynthetic process GO:0008915//GO:0035064 lipid-A-disaccharide synthase activity//methylated histone binding -- -- -- -- Cluster-8309.10278 BF_2 40.16 1.41 1481 270011134 EFA07582.1 1302 1.0e-140 invected [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10287 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10290 BF_2 11.66 0.54 1192 332373854 AEE62068.1 1206 1.1e-129 unknown [Dendroctonus ponderosae] 642918806 XM_008193372.1 152 1.69126e-71 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase PP1-alpha-like (LOC103312533), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q7SZ10 1045 2.1e-112 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit B OS=Xenopus laevis GN=ppp1cc-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.10291 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10304 BF_2 5.62 0.33 1004 642940305 XP_008199674.1 185 2.3e-11 PREDICTED: uncharacterized protein LOC103314729 [Tribolium castaneum]>gi|270017203|gb|EFA13649.1| hypothetical protein TcasGA2_TC004984 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10307 BF_2 5.00 1.15 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10309 BF_2 4.00 0.36 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1031 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10310 BF_2 5.00 0.34 894 91076304 XP_969164.1 297 2.1e-24 PREDICTED: eclosion hormone [Tribolium castaneum]>gi|642912177|ref|XP_008200840.1| PREDICTED: eclosion hormone [Tribolium castaneum]>gi|270002925|gb|EEZ99372.1| eclosion hormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11919 232 3.0e-18 Eclosion hormone OS=Manduca sexta PE=1 SV=2 PF04736 Eclosion hormone GO:0018990//GO:0007218 ecdysis, chitin-based cuticle//neuropeptide signaling pathway GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8309.10315 BF_2 1.00 1.15 311 546682555 ERL92478.1 177 6.0e-11 hypothetical protein D910_09791 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10326 BF_2 3.00 0.38 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10330 BF_2 288.00 3.88 3396 768409110 XP_011551077.1 896 2.8e-93 PREDICTED: elongation of very long chain fatty acids protein AAEL008004-like isoform X2 [Plutella xylostella] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 618 2.0e-62 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10345 BF_2 25.21 0.40 2891 719764165 XP_010216927.1 367 5.2e-32 PREDICTED: collagen alpha-1(I) chain, partial [Tinamus guttatus] -- -- -- -- -- -- -- -- -- P02453 359 1.8e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF10660//PF06482 Iron-containing outer mitochondrial membrane protein N-terminus//Collagenase NC10 and Endostatin GO:0007155 cell adhesion GO:0051537//GO:0005198 2 iron, 2 sulfur cluster binding//structural molecule activity GO:0031012//GO:0043231 extracellular matrix//intracellular membrane-bounded organelle -- -- Cluster-8309.10363 BF_2 107.27 9.41 764 642930121 XP_008196261.1 342 1.1e-29 PREDICTED: acylphosphatase-1-like [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P24540 288 8.2e-25 Acylphosphatase-1 OS=Sus scrofa GN=ACYP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3360 Acylphosphatase Cluster-8309.10366 BF_2 3.00 4.67 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10368 BF_2 20.85 0.59 1755 260807253 XP_002598423.1 305 4.9e-25 hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae]>gi|229283696|gb|EEN54435.1| hypothetical protein BRAFLDRAFT_83207 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9NPA5 202 1.8e-14 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF00096//PF13465//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.1037 BF_2 2.00 0.64 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10372 BF_2 172.00 6.98 1318 189236180 XP_967893.2 907 5.8e-95 PREDICTED: serine hydrolase-like protein [Tribolium castaneum]>gi|270005749|gb|EFA02197.1| hypothetical protein TcasGA2_TC007853 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2BGU9 342 7.8e-31 Serine hydrolase-like protein OS=Danio rerio GN=serhl PE=2 SV=1 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.10373 BF_2 81.00 1.97 2011 478253705 ENN74004.1 452 5.1e-42 hypothetical protein YQE_09394, partial [Dendroctonus ponderosae]>gi|546678194|gb|ERL88884.1| hypothetical protein D910_06266 [Dendroctonus ponderosae] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q00871 350 1.4e-31 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.10380 BF_2 44.24 1.10 1976 91084727 XP_970450.1 1794 1.2e-197 PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|642925824|ref|XP_008190453.1| PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|270008937|gb|EFA05385.1| hypothetical protein TcasGA2_TC015557 [Tribolium castaneum] 242000649 XM_002434923.1 66 1.81986e-23 Ixodes scapularis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10382 BF_2 6.00 0.34 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10389 BF_2 5.00 0.37 846 821027387 XP_012356888.1 678 1.3e-68 PREDICTED: profilin-1 isoform X2 [Nomascus leucogenys] 394582017 NM_005022.3 835 0 Homo sapiens profilin 1 (PFN1), mRNA K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 P07737 660 6.6e-68 Profilin-1 OS=Homo sapiens GN=PFN1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10390 BF_2 2.00 2.74 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10391 BF_2 4.95 0.35 881 826407466 XP_012543053.1 180 7.7e-11 PREDICTED: zinc finger protein 184-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- P42283 142 8.0e-08 Longitudinals lacking protein, isoform G OS=Drosophila melanogaster GN=lola PE=1 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.10397 BF_2 12.06 1.07 757 91089041 XP_969722.1 348 2.2e-30 PREDICTED: EKC/KEOPS complex subunit Tprkb [Tribolium castaneum]>gi|270012398|gb|EFA08846.1| hypothetical protein TcasGA2_TC006547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y3C4 219 8.2e-17 EKC/KEOPS complex subunit TPRKB OS=Homo sapiens GN=TPRKB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10400 BF_2 5.00 1.30 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10406 BF_2 38.78 0.53 3326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10413 BF_2 15.74 0.93 992 667755293 AIG92783.1 612 7.0e-61 extracellular superoxide dismutase [Dastarcus helophoroides] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 373 1.5e-34 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.1042 BF_2 4.40 0.31 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10420 BF_2 2.00 1.73 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10423 BF_2 18.00 2.74 562 700346190 XP_009917077.1 506 7.7e-49 PREDICTED: elongation factor 1-alpha 1, partial [Haliaeetus albicilla] 306416024 GQ848074.1 538 0 Oryza sativa Japonica Group clone KCG053D09 elongation factor-1 alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 O64937 547 5.6e-55 Elongation factor 1-alpha OS=Oryza sativa subsp. japonica GN=REFA1 PE=2 SV=2 PF02774 Semialdehyde dehydrogenase, dimerisation domain GO:0008652//GO:0055114//GO:0000051 cellular amino acid biosynthetic process//oxidation-reduction process//obsolete urea cycle intermediate metabolic process GO:0003942//GO:0046983//GO:0016620 N-acetyl-gamma-glutamyl-phosphate reductase activity//protein dimerization activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0005737 cytoplasm KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.10424 BF_2 19.00 1.41 851 803119291 XP_012040812.1 830 3.1e-86 PREDICTED: elongation factor 1-alpha 1-like isoform X1 [Ovis aries] 50980343 AY643400.1 593 0 Pimephales promelas elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P13549 800 3.9e-84 Elongation factor 1-alpha, somatic form OS=Xenopus laevis GN=eef1as PE=2 SV=1 PF02774//PF03144 Semialdehyde dehydrogenase, dimerisation domain//Elongation factor Tu domain 2 GO:0055114//GO:0008652//GO:0000051 oxidation-reduction process//cellular amino acid biosynthetic process//obsolete urea cycle intermediate metabolic process GO:0016620//GO:0005525//GO:0003942//GO:0046983 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//GTP binding//N-acetyl-gamma-glutamyl-phosphate reductase activity//protein dimerization activity GO:0005737 cytoplasm KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.10425 BF_2 28.00 7.40 445 149207941 ABR21646.1 757 4.8e-78 elongation factor 1-alpha [Bacillus rossius redtenbacheri] 306416020 GQ848072.1 442 0 Oryza sativa Japonica Group clone KCG182G02 elongation factor-1 alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 O64937 782 2.5e-82 Elongation factor 1-alpha OS=Oryza sativa subsp. japonica GN=REFA1 PE=2 SV=2 PF02662//PF03144 Methyl-viologen-reducing hydrogenase, delta subunit//Elongation factor Tu domain 2 GO:0055114//GO:0015948 oxidation-reduction process//methanogenesis GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.10428 BF_2 2.00 0.53 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10433 BF_2 11.98 0.43 1441 642913546 XP_008201056.1 290 2.2e-23 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- K08209 SLC22A13 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08209 Q6A4L0 185 1.4e-12 Solute carrier family 22 member 13 OS=Mus musculus GN=Slc22a13 PE=2 SV=3 PF00324 Amino acid permease GO:0055085//GO:0006810 transmembrane transport//transport -- -- GO:0016020 membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.10435 BF_2 42.00 1.38 1563 553832083 AGY61452.1 1699 9.9e-187 photosystem II D2 protein [Lotharella sp. CCMP622] 353685124 JN861110.1 1560 0 Oryza sativa Indica Group chloroplast, complete genome -- -- -- -- P0C437 1829 3.4e-203 Photosystem II D2 protein OS=Oryza sativa subsp. japonica GN=psbD PE=3 SV=1 PF00187//PF00421//PF00124 Chitin recognition protein//Photosystem II protein//Photosynthetic reaction centre protein GO:0009767//GO:0006118//GO:0009772//GO:0019684 photosynthetic electron transport chain//obsolete electron transport//photosynthetic electron transport in photosystem II//photosynthesis, light reaction GO:0016168//GO:0045156//GO:0008061 chlorophyll binding//electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//chitin binding GO:0009521//GO:0016020 photosystem//membrane -- -- Cluster-8309.10440 BF_2 108.70 0.82 5862 478257774 ENN77917.1 2916 0.0e+00 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B2GUN4 1110 3.0e-119 Meiosis arrest female protein 1 homolog OS=Xenopus tropicalis GN=marf1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.10443 BF_2 28.50 0.59 2309 642927459 XP_968905.2 1040 3.8e-110 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q3SZJ4 752 3.9e-78 Prostaglandin reductase 1 OS=Bos taurus GN=PTGR1 PE=2 SV=1 PF02826//PF00107//PF01370//PF00106//PF01118 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0016620//GO:0051287//GO:0003824//GO:0050662 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.10450 BF_2 18.82 0.70 1405 270003361 EEZ99808.1 933 5.9e-98 hypothetical protein TcasGA2_TC002588 [Tribolium castaneum] -- -- -- -- -- K10578 UBE2J1, NCUBE1, UBC6 ubiquitin-conjugating enzyme E2 J1 http://www.genome.jp/dbget-bin/www_bget?ko:K10578 Q9JJZ4 663 5.0e-68 Ubiquitin-conjugating enzyme E2 J1 OS=Mus musculus GN=Ube2j1 PE=1 SV=2 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0894 Ubiquitin-protein ligase Cluster-8309.10451 BF_2 194.93 6.12 1619 270003361 EEZ99808.1 933 6.8e-98 hypothetical protein TcasGA2_TC002588 [Tribolium castaneum] -- -- -- -- -- K10578 UBE2J1, NCUBE1, UBC6 ubiquitin-conjugating enzyme E2 J1 http://www.genome.jp/dbget-bin/www_bget?ko:K10578 Q9JJZ4 663 5.7e-68 Ubiquitin-conjugating enzyme E2 J1 OS=Mus musculus GN=Ube2j1 PE=1 SV=2 PF08043//PF05773 Xin repeat//RWD domain GO:0030036 actin cytoskeleton organization GO:0005515//GO:0003779 protein binding//actin binding GO:0030054 cell junction KOG0894 Ubiquitin-protein ligase Cluster-8309.10455 BF_2 57.35 2.31 1327 820805550 AKG92766.1 799 1.9e-82 Mlx interactor [Leptinotarsa decemlineata] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9HAP2 261 1.9e-21 MLX-interacting protein OS=Homo sapiens GN=MLXIP PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3582 Mlx interactors and related transcription factors Cluster-8309.10458 BF_2 18.00 0.37 2343 91089117 XP_972346.1 1590 6.5e-174 PREDICTED: pickpocket protein 28-like [Tribolium castaneum] -- -- -- -- -- K03440 ASICN amiloride-sensitive sodium channel, other http://www.genome.jp/dbget-bin/www_bget?ko:K03440 Q86LG1 495 2.5e-48 Pickpocket protein 28 OS=Drosophila melanogaster GN=ppk28 PE=1 SV=2 PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.10463 BF_2 34.06 0.37 4154 642935200 XP_966348.3 1752 1.9e-192 PREDICTED: kelch-like ECH-associated protein 1 isoform X1 [Tribolium castaneum] 642935203 XM_008201467.1 274 9.12011e-139 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 945 2.9e-100 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF07646//PF00651//PF01344//PF00569 Kelch motif//BTB/POZ domain//Kelch motif//Zinc finger, ZZ type -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.10464 BF_2 48.19 0.52 4147 642935202 XP_008199688.1 1752 1.9e-192 PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|642935204|ref|XP_008199689.1| PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|270014185|gb|EFA10633.1| hypothetical protein TcasGA2_TC016270 [Tribolium castaneum] 642935203 XM_008201467.1 274 9.10461e-139 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 945 2.9e-100 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10479 BF_2 4.00 0.41 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10486 BF_2 13.10 0.41 1609 642918318 XP_008191457.1 453 3.1e-42 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642918317 XM_008193235.1 135 6.48827e-62 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC656006), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9ERC8 218 2.3e-16 Down syndrome cell adhesion molecule homolog OS=Mus musculus GN=Dscam PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10488 BF_2 1.00 0.49 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10489 BF_2 111.00 1.52 3337 91092544 XP_968085.1 3696 0.0e+00 PREDICTED: pre-mRNA-splicing factor SYF1 [Tribolium castaneum] 820865169 XM_003698678.2 629 0 PREDICTED: Apis florea pre-mRNA-splicing factor SYF1 (LOC100869086), transcript variant X1, mRNA K12867 SYF1, XAB2 pre-mRNA-splicing factor SYF1 http://www.genome.jp/dbget-bin/www_bget?ko:K12867 Q9DCD2 2766 1.6e-311 Pre-mRNA-splicing factor SYF1 OS=Mus musculus GN=Xab2 PE=2 SV=1 PF13374//PF00515//PF13414//PF13176//PF07378//PF05225//PF13181//PF05843 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Flagellar protein FlbT//helix-turn-helix, Psq domain//Tetratricopeptide repeat//Suppressor of forked protein (Suf) GO:1902209//GO:0006402//GO:0006397 negative regulation of bacterial-type flagellum assembly//mRNA catabolic process//mRNA processing GO:0005515//GO:0003677//GO:0048027 protein binding//DNA binding//mRNA 5'-UTR binding GO:0005634 nucleus KOG2047 mRNA splicing factor Cluster-8309.10491 BF_2 1.00 3.74 262 227018328 ACP18830.1 247 3.9e-19 cysteine proteinase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- O97397 226 4.3e-18 Cathepsin L-like proteinase OS=Phaedon cochleariae PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10492 BF_2 188.00 8.97 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.10496 BF_2 150.07 4.12 1811 546671622 ERL83856.1 140 6.9e-06 hypothetical protein D910_01123 [Dendroctonus ponderosae]>gi|546672359|gb|ERL84263.1| hypothetical protein D910_01644 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05399//PF06687//PF11837//PF09480//PF10717//PF05434 Ectropic viral integration site 2A protein (EVI2A)//SUR7/PalI family//Domain of unknown function (DUF3357)//Type III secretion system protein PrgH-EprH (PrgH)//Occlusion-derived virus envelope protein ODV-E18//TMEM9 GO:0005982//GO:0005985//GO:0006012 starch metabolic process//sucrose metabolic process//galactose metabolic process GO:0004575//GO:0004564 sucrose alpha-glucosidase activity//beta-fructofuranosidase activity GO:0017177//GO:0019031//GO:0016021//GO:0005886 glucosidase II complex//viral envelope//integral component of membrane//plasma membrane -- -- Cluster-8309.10499 BF_2 7.00 0.34 1137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14955 Mitochondrial ribosome subunit S24 -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.10500 BF_2 28.00 0.33 3835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10511 BF_2 20.59 1.52 853 91091178 XP_971714.1 453 1.6e-42 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 308 4.4e-27 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF00441//PF01756 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA oxidase GO:0055114//GO:0006635//GO:0044710//GO:0006637 oxidation-reduction process//fatty acid beta-oxidation//single-organism metabolic process//acyl-CoA metabolic process GO:0016627//GO:0003997 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.10513 BF_2 101.00 3.64 1448 91081587 XP_975337.1 1067 1.8e-113 PREDICTED: programmed cell death protein 2 [Tribolium castaneum]>gi|270005104|gb|EFA01552.1| hypothetical protein TcasGA2_TC007113 [Tribolium castaneum] -- -- -- -- -- K14801 TSR4 pre-rRNA-processing protein TSR4 http://www.genome.jp/dbget-bin/www_bget?ko:K14801 P47816 695 9.9e-72 Programmed cell death protein 2 OS=Rattus norvegicus GN=Pdcd2 PE=2 SV=2 PF04194 Programmed cell death protein 2, C-terminal putative domain -- -- -- -- GO:0005737 cytoplasm KOG2061 Uncharacterized MYND Zn-finger protein Cluster-8309.10517 BF_2 29.00 0.56 2437 122227452 Q06J66.1 2089 9.2e-232 RecName: Full=Photosystem II CP43 reaction center protein; AltName: Full=PSII 43 kDa protein; AltName: Full=Protein CP-43; Flags: Precursor>gi|110810187|gb|ABG91393.1| photosystem II 43 kDa protein [Bigelowiella natans] 597569085 KF990036.1 2350 0 Prunus kansuensis chloroplast, complete genome -- -- -- -- Q7YJX6 2285 7.1e-256 Photosystem II CP43 reaction center protein OS=Calycanthus floridus var. glaucus GN=psbC PE=3 SV=1 PF00124//PF00421 Photosynthetic reaction centre protein//Photosystem II protein GO:0018298//GO:0009772//GO:0019684//GO:0006118//GO:0009767 protein-chromophore linkage//photosynthetic electron transport in photosystem II//photosynthesis, light reaction//obsolete electron transport//photosynthetic electron transport chain GO:0045156//GO:0016168 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//chlorophyll binding GO:0009521//GO:0016021//GO:0009523//GO:0009535//GO:0030076//GO:0016020 photosystem//integral component of membrane//photosystem II//chloroplast thylakoid membrane//light-harvesting complex//membrane -- -- Cluster-8309.10528 BF_2 6.03 0.58 720 91089817 XP_969063.1 215 5.5e-15 PREDICTED: protein anon-73B1 [Tribolium castaneum]>gi|270013595|gb|EFA10043.1| hypothetical protein TcasGA2_TC012215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01741//PF06783 Large-conductance mechanosensitive channel, MscL//Uncharacterised protein family (UPF0239) GO:0006811//GO:0006810 ion transport//transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.10532 BF_2 36.59 0.42 3964 642938488 XP_008197979.1 2563 1.6e-286 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X3 [Tribolium castaneum] 805759873 XM_012297744.1 247 8.88593e-124 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.6e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- -- -- Cluster-8309.10536 BF_2 29.00 0.99 1515 571330974 AHF27419.1 1052 1.0e-111 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- B4QBN3 600 1.1e-60 Facilitated trehalose transporter Tret1-2 homolog OS=Drosophila simulans GN=Tret1-2 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.10548 BF_2 452.44 14.45 1597 91081053 XP_975382.1 1024 1.9e-108 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270005322|gb|EFA01770.1| hypothetical protein TcasGA2_TC007369 [Tribolium castaneum] -- -- -- -- -- K00019 E1.1.1.30, bdh 3-hydroxybutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00019 P29147 243 2.8e-19 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Bdh1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.10549 BF_2 65.49 3.76 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.10550 BF_2 59.51 2.63 1234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.10554 BF_2 107.42 1.13 4251 642910211 XP_008198422.1 662 4.8e-66 PREDICTED: cation-independent mannose-6-phosphate receptor [Tribolium castaneum]>gi|642910213|ref|XP_008198425.1| PREDICTED: cation-independent mannose-6-phosphate receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11717 212 3.0e-15 Cation-independent mannose-6-phosphate receptor OS=Homo sapiens GN=IGF2R PE=1 SV=3 PF00878 Cation-independent mannose-6-phosphate receptor repeat GO:0006810 transport GO:0005215 transporter activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.10561 BF_2 7.00 0.44 948 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10573 BF_2 33.22 1.15 1491 332374108 AEE62195.1 801 1.3e-82 unknown [Dendroctonus ponderosae]>gi|478251122|gb|ENN71598.1| hypothetical protein YQE_11697, partial [Dendroctonus ponderosae]>gi|546680336|gb|ERL90622.1| hypothetical protein D910_07969 [Dendroctonus ponderosae] -- -- -- -- -- K06971 K06971 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06971 Q1NZ26 497 9.3e-49 Uncharacterized protein F13E9.13, mitochondrial OS=Caenorhabditis elegans GN=F13E9.13 PE=3 SV=1 PF00977//PF00290//PF02679 Histidine biosynthesis protein//Tryptophan synthase alpha chain//(2R)-phospho-3-sulfolactate synthase (ComA) GO:0009094//GO:0006568//GO:0000162//GO:0019295//GO:0006571//GO:0000105 L-phenylalanine biosynthetic process//tryptophan metabolic process//tryptophan biosynthetic process//coenzyme M biosynthetic process//tyrosine biosynthetic process//histidine biosynthetic process GO:0004834 tryptophan synthase activity -- -- -- -- Cluster-8309.10574 BF_2 6.78 0.83 628 332374108 AEE62195.1 352 6.2e-31 unknown [Dendroctonus ponderosae]>gi|478251122|gb|ENN71598.1| hypothetical protein YQE_11697, partial [Dendroctonus ponderosae]>gi|546680336|gb|ERL90622.1| hypothetical protein D910_07969 [Dendroctonus ponderosae] -- -- -- -- -- K06971 K06971 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06971 Q1NZ26 167 7.2e-11 Uncharacterized protein F13E9.13, mitochondrial OS=Caenorhabditis elegans GN=F13E9.13 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10583 BF_2 64.36 1.34 2296 642934129 XP_008199288.1 888 1.6e-92 PREDICTED: putative zinc metalloproteinase YIL108W isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10585 BF_2 2.00 0.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10587 BF_2 26.83 2.72 700 270002524 EEZ98971.1 485 2.6e-46 hypothetical protein TcasGA2_TC004826 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10588 BF_2 24.56 0.82 1545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- -- -- Cluster-8309.10599 BF_2 7.00 1.23 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10600 BF_2 7.00 0.38 1053 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10608 BF_2 51.54 0.45 5089 780175874 XP_011661330.1 388 3.4e-34 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 299 2.9e-25 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF04851//PF12515//PF13606//PF00023//PF11421//PF00004 Type III restriction enzyme, res subunit//Ca2+-ATPase N terminal autoinhibitory domain//Ankyrin repeat//Ankyrin repeat//ATP synthase F1 beta subunit//ATPase family associated with various cellular activities (AAA) GO:0006754 ATP biosynthetic process GO:0016887//GO:0005524//GO:0005516//GO:0003677//GO:0016787//GO:0005515 ATPase activity//ATP binding//calmodulin binding//DNA binding//hydrolase activity//protein binding GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.10610 BF_2 1.00 0.39 394 861599125 KMQ83546.1 191 1.8e-12 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10618 BF_2 116.97 2.57 2193 642918886 XP_008191628.1 1136 2.7e-121 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 358 1.8e-32 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF14372 Acyltransferase family//Domain of unknown function (DUF4413) -- -- GO:0016747//GO:0003677 transferase activity, transferring acyl groups other than amino-acyl groups//DNA binding -- -- -- -- Cluster-8309.10622 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10627 BF_2 2.00 0.58 430 557018159 XP_006009466.1 160 7.8e-09 PREDICTED: uncharacterized protein LOC102349681 isoform X1 [Latimeria chalumnae]>gi|557018161|ref|XP_006009467.1| PREDICTED: uncharacterized protein LOC102349681 isoform X2 [Latimeria chalumnae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10631 BF_2 4.55 0.47 690 665814372 XP_008555793.1 307 1.1e-25 PREDICTED: ankyrin repeat domain-containing protein 39 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- Q0P5B9 259 1.7e-21 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.10640 BF_2 17.00 0.49 1743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10648 BF_2 76.00 5.66 849 91081297 XP_968817.1 603 6.6e-60 PREDICTED: protein cornichon homolog 4 [Tribolium castaneum] 755947428 XM_011302162.1 60 1.65458e-20 PREDICTED: Fopius arisanus protein cornichon homolog 4 (LOC105264936), mRNA -- -- -- -- Q3T126 409 8.5e-39 Protein cornichon homolog 4 OS=Bos taurus GN=CNIH4 PE=2 SV=1 PF03311//PF02902 Cornichon protein//Ulp1 protease family, C-terminal catalytic domain GO:0006508//GO:0035556 proteolysis//intracellular signal transduction GO:0008234 cysteine-type peptidase activity GO:0016020 membrane KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.10651 BF_2 108.72 4.43 1314 642911443 XP_008199425.1 1224 1.0e-131 PREDICTED: hydroxymethylglutaryl-CoA lyase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01640 E4.1.3.4, HMGCL, hmgL hydroxymethylglutaryl-CoA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01640 D4A5C3 969 1.5e-103 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic OS=Rattus norvegicus GN=Hmgcll1 PE=1 SV=1 PF00682 HMGL-like -- -- GO:0003824 catalytic activity -- -- KOG2368 Hydroxymethylglutaryl-CoA lyase Cluster-8309.10655 BF_2 4.00 0.41 700 668448475 KFB38130.1 148 3.1e-07 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10662 BF_2 100.00 2.25 2145 642916699 XP_008192238.1 1187 3.2e-127 PREDICTED: forkhead box protein F1-like [Tribolium castaneum]>gi|642916701|ref|XP_008192244.1| PREDICTED: forkhead box protein F1-like [Tribolium castaneum] 642916698 XM_008194016.1 456 0 PREDICTED: Tribolium castaneum forkhead box protein F1-like (LOC100142613), transcript variant X1, mRNA K09399 FOXF forkhead box protein F http://www.genome.jp/dbget-bin/www_bget?ko:K09399 O54743 446 1.1e-42 Forkhead box protein F2 OS=Mus musculus GN=Foxf2 PE=2 SV=2 PF00250//PF00879 Forkhead domain//Defensin propeptide GO:0006952//GO:0006355 defense response//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.10670 BF_2 20.47 0.51 1962 443733809 ELU18029.1 428 3.0e-39 hypothetical protein CAPTEDRAFT_197670 [Capitella teleta] -- -- -- -- -- -- -- -- -- Q2R837 129 5.8e-06 PHD finger protein ALFIN-LIKE 8 OS=Oryza sativa subsp. japonica GN=Os11g0244800 PE=2 SV=1 PF03184//PF05225 DDE superfamily endonuclease//helix-turn-helix, Psq domain -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.10675 BF_2 61.65 3.78 969 642922841 XP_001813804.2 546 3.1e-53 PREDICTED: uncharacterized protein LOC100141768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297//PF03694 Herpesvirus latent membrane protein 1 (LMP1)//Erg28 like protein GO:0019087 transformation of host cell by virus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10676 BF_2 9.23 0.45 1147 642922841 XP_001813804.2 351 1.5e-30 PREDICTED: uncharacterized protein LOC100141768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03694 Erg28 like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.10678 BF_2 7.00 0.35 1115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10681 BF_2 15.00 0.34 2122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07677 A-macroglobulin receptor -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.1069 BF_2 4.00 0.41 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10695 BF_2 1.00 0.47 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10705 BF_2 4.00 0.49 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10707 BF_2 43.84 1.33 1663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10709 BF_2 11.51 0.31 1825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10712 BF_2 33.00 1.77 1066 478255888 ENN76095.1 169 1.7e-09 hypothetical protein YQE_07378, partial [Dendroctonus ponderosae]>gi|478266978|gb|ENN82965.1| hypothetical protein YQE_00671, partial [Dendroctonus ponderosae]>gi|478269605|gb|ENN83363.1| hypothetical protein YQE_00278, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P26967 151 8.8e-09 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10715 BF_2 9.00 0.63 888 300394164 ADK11708.1 574 1.6e-56 aminopeptidase N [Gastrophysa viridula] -- -- -- -- -- -- -- -- -- Q11001 218 1.2e-16 Membrane alanyl aminopeptidase (Fragment) OS=Manduca sexta PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10717 BF_2 1.68 0.36 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10718 BF_2 5.00 0.45 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10719 BF_2 32.28 0.64 2410 478256729 ENN76910.1 1562 1.2e-170 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 394 1.3e-36 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF04843//PF09429//PF00083 Major Facilitator Superfamily//Herpesvirus tegument protein, N-terminal conserved region//WW domain binding protein 11//Sugar (and other) transporter GO:0006396//GO:0006508//GO:0055085 RNA processing//proteolysis//transmembrane transport GO:0008233//GO:0022857 peptidase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.10724 BF_2 4.00 0.39 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10742 BF_2 12.00 0.96 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06610 L-alanine exporter -- -- GO:0034639 L-amino acid efflux transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.10747 BF_2 12.00 0.51 1267 642940001 XP_008198792.1 478 3.1e-45 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10749 BF_2 1.71 0.44 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10753 BF_2 41.00 0.87 2258 642936737 XP_008198559.1 541 2.7e-52 PREDICTED: kinetochore protein NDC80 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4X5 214 9.2e-16 Kinetochore protein NDC80 homolog OS=Xenopus tropicalis GN=ndc80 PE=2 SV=1 PF00765//PF00170//PF05791//PF03836//PF00700 Autoinducer synthase//bZIP transcription factor//Bacillus haemolytic enterotoxin (HBL)//RasGAP C-terminus//Bacterial flagellin C-terminal helical region GO:0006355//GO:0007264//GO:0009405//GO:0071973 regulation of transcription, DNA-templated//small GTPase mediated signal transduction//pathogenesis//bacterial-type flagellum-dependent cell motility GO:0043565//GO:0003700//GO:0005096//GO:0016740//GO:0005198 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//GTPase activator activity//transferase activity//structural molecule activity GO:0016020//GO:0005667 membrane//transcription factor complex -- -- Cluster-8309.10757 BF_2 100.29 2.93 1720 478259436 ENN79326.1 829 8.3e-86 hypothetical protein YQE_04235, partial [Dendroctonus ponderosae]>gi|546675177|gb|ERL86413.1| hypothetical protein D910_03820 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P41951 138 4.6e-07 Prion-like-(Q/N-rich) domain-bearing protein 25 OS=Caenorhabditis elegans GN=pqn-25 PE=4 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10758 BF_2 101.75 1.76 2711 357621647 EHJ73416.1 189 2.1e-11 putative pol-like protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00075//PF02723 RNase H//Non-structural protein NS3/Small envelope protein E GO:0051252 regulation of RNA metabolic process GO:0004523//GO:0003676 RNA-DNA hybrid ribonuclease activity//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.10759 BF_2 39.26 0.63 2892 642930067 XP_008196236.1 3292 0.0e+00 PREDICTED: nephrin-like [Tribolium castaneum] 642930066 XM_008198014.1 458 0 PREDICTED: Tribolium castaneum nephrin-like (LOC663423), mRNA -- -- -- -- A2AJ76 208 5.9e-15 Hemicentin-2 OS=Mus musculus GN=Hmcn2 PE=2 SV=1 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10760 BF_2 29.00 1.42 1141 -- -- -- -- -- 528540458 AP012528.1 927 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- Q00058 853 3.7e-90 ATP synthase protein MI25 OS=Oryza sativa subsp. indica PE=3 SV=1 PF16497//PF05405 MHC-I family domain//Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015986//GO:0006955//GO:0015992 ATP synthesis coupled proton transport//immune response//proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- -- -- Cluster-8309.10763 BF_2 45.00 1.27 1766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10767 BF_2 3.00 1.16 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10772 BF_2 58.18 0.85 3157 189237912 XP_969631.2 2893 0.0e+00 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q9JHD2 1837 8.2e-204 Histone acetyltransferase KAT2A OS=Mus musculus GN=Kat2a PE=1 SV=2 PF13673//PF00583//PF06472//PF13508//PF00439//PF06466 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//ABC transporter transmembrane region 2//Acetyltransferase (GNAT) domain//Bromodomain//PCAF (P300/CBP-associated factor) N-terminal domain GO:0006355//GO:0055085//GO:0016573//GO:0006810//GO:0042967 regulation of transcription, DNA-templated//transmembrane transport//histone acetylation//transport//acyl-carrier-protein biosynthetic process GO:0042626//GO:0005524//GO:0008080//GO:0004402//GO:0005515 ATPase activity, coupled to transmembrane movement of substances//ATP binding//N-acetyltransferase activity//histone acetyltransferase activity//protein binding GO:0000123//GO:0005634//GO:0016021 histone acetyltransferase complex//nucleus//integral component of membrane KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.10774 BF_2 15.13 0.73 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10791 BF_2 31.56 0.64 2344 190702371 ACE75264.1 1009 1.5e-106 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175//PF01363//PF00096//PF08685 DNA polymerase type B, organellar and viral//FYVE zinc finger//Zinc finger, C2H2 type//GON domain GO:0006260 DNA replication GO:0046872//GO:0000166//GO:0008270//GO:0008408//GO:0003887//GO:0004222//GO:0003677 metal ion binding//nucleotide binding//zinc ion binding//3'-5' exonuclease activity//DNA-directed DNA polymerase activity//metalloendopeptidase activity//DNA binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.10795 BF_2 3.00 11.22 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10796 BF_2 60.00 1.39 2094 795016637 XP_011858564.1 326 2.1e-27 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03943//PF01708 TAP C-terminal domain//Geminivirus putative movement protein GO:0046740//GO:0051028 transport of virus in host, cell to cell//mRNA transport -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.10805 BF_2 3.00 2.60 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10807 BF_2 69.34 0.60 5104 817074162 XP_012259260.1 369 5.4e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.10808 BF_2 3.00 0.43 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1081 BF_2 18.40 0.86 1186 189238680 XP_966563.2 848 3.6e-88 PREDICTED: cytochrome P450 4C1-like [Tribolium castaneum] 657941332 KM016726.1 34 6.63423e-06 Helicoverpa armigera cytochrome P450 CYP4L11 (CYP4L11) mRNA, complete cds K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 653 6.0e-67 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.10814 BF_2 112.00 1.50 3406 642932284 XP_008197048.1 2632 1.4e-294 PREDICTED: lysosomal alpha-mannosidase-like [Tribolium castaneum]>gi|270012319|gb|EFA08767.1| hypothetical protein TcasGA2_TC006455 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q60HE9 1759 9.8e-195 Lysosomal alpha-mannosidase OS=Macaca fascicularis GN=MAN2B1 PE=2 SV=1 PF01074//PF07748//PF09261 Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Alpha mannosidase, middle domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0008270//GO:0005488//GO:0004553//GO:0004559//GO:0015923 zinc ion binding//binding//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.10816 BF_2 16.07 1.80 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF01082 THAP domain//Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114 oxidation-reduction process GO:0016715//GO:0004497//GO:0003676//GO:0005507 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity//nucleic acid binding//copper ion binding -- -- -- -- Cluster-8309.10824 BF_2 60.90 0.68 4029 642926929 XP_008195061.1 1542 4.1e-168 PREDICTED: uncharacterized protein LOC100141786 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10827 BF_2 34.61 0.68 2417 780693755 XP_011700257.1 1127 3.3e-120 PREDICTED: uncharacterized protein LOC105457338 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04574//PF03175 Protein of unknown function (DUF592)//DNA polymerase type B, organellar and viral GO:0006342//GO:0006476//GO:0006355//GO:0006260//GO:0006807 chromatin silencing//protein deacetylation//regulation of transcription, DNA-templated//DNA replication//nitrogen compound metabolic process GO:0003677//GO:0016811//GO:0051287//GO:0017136//GO:0003887//GO:0008270//GO:0000166//GO:0008408 DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD binding//NAD-dependent histone deacetylase activity//DNA-directed DNA polymerase activity//zinc ion binding//nucleotide binding//3'-5' exonuclease activity GO:0042575//GO:0000118 DNA polymerase complex//histone deacetylase complex -- -- Cluster-8309.10834 BF_2 3.73 0.45 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10837 BF_2 75.00 28.98 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537 Scorpion toxin-like domain GO:0006810 transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.10838 BF_2 8.00 1.58 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10843 BF_2 116.12 1.51 3507 817324046 XP_012332723.1 243 1.5e-17 PREDICTED: zinc finger protein 808, partial [Aotus nancymaae] 642918103 XM_008195805.1 309 2.68767e-158 PREDICTED: Tribolium castaneum Krueppel-like factor 6 (LOC103313193), transcript variant X2, mRNA K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q5VIY5 232 1.2e-17 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF15060//PF00471//PF00096//PF13465 C2H2-type zinc finger//Differentiation and proliferation regulator//Ribosomal protein L33//Zinc finger, C2H2 type//Zinc-finger double domain GO:0042254//GO:0030154//GO:0006412//GO:0007275 ribosome biogenesis//cell differentiation//translation//multicellular organismal development GO:0046872//GO:0003735 metal ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.10844 BF_2 57.00 1.42 1965 478263043 ENN81443.1 1545 9.0e-169 hypothetical protein YQE_02136, partial [Dendroctonus ponderosae] -- -- -- -- -- K16674 FJX1 four-jointed box protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16674 P54360 935 2.0e-99 Extracellular serine/threonine protein kinase four-jointed OS=Drosophila melanogaster GN=fj PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10846 BF_2 23.37 2.39 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00569 Zinc finger, ZZ type -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.10852 BF_2 4.00 1.76 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10855 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10860 BF_2 6.00 0.35 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10861 BF_2 0.78 3.28 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10866 BF_2 33.36 2.09 954 91084083 XP_966773.1 515 1.2e-49 PREDICTED: uncharacterized protein LOC656652 [Tribolium castaneum]>gi|270008009|gb|EFA04457.1| hypothetical protein TcasGA2_TC014761 [Tribolium castaneum] 462298889 APGK01051512.1 56 3.12541e-18 Dendroctonus ponderosae Seq01051522, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10869 BF_2 17.62 0.67 1383 91078614 XP_967493.1 1057 2.4e-112 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 38 4.6432e-08 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 O43752 526 3.7e-52 Syntaxin-6 OS=Homo sapiens GN=STX6 PE=1 SV=1 PF05478//PF05739//PF00957//PF00523 Prominin//SNARE domain//Synaptobrevin//Fusion glycoprotein F0 GO:0016192//GO:0006948 vesicle-mediated transport//induction by virus of host cell-cell fusion GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.10873 BF_2 91.00 5.88 935 91089477 XP_969208.1 235 3.4e-17 PREDICTED: zinc finger HIT domain-containing protein 3 [Tribolium castaneum]>gi|270012577|gb|EFA09025.1| hypothetical protein TcasGA2_TC006734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQK1 149 1.3e-08 Zinc finger HIT domain-containing protein 3 OS=Mus musculus GN=Znhit3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10877 BF_2 7.00 0.31 1232 -- -- -- -- -- 462276582 APGK01059353.1 39 1.14637e-08 Dendroctonus ponderosae Seq01059363, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10880 BF_2 2.00 1.02 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10882 BF_2 4.00 0.56 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10883 BF_2 91.91 0.70 5779 642934786 XP_008197807.1 453 1.1e-41 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270013455|gb|EFA09903.1| hypothetical protein TcasGA2_TC012053 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10888 BF_2 4.00 0.42 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10894 BF_2 25.00 0.47 2533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10896 BF_2 170.12 4.85 1755 91094191 XP_971121.1 2131 9.0e-237 PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|642928139|ref|XP_008200172.1| PREDICTED: general transcription factor IIH subunit 4 [Tribolium castaneum]>gi|270010854|gb|EFA07302.1| hypothetical protein TcasGA2_TC015892 [Tribolium castaneum] -- -- -- -- -- K03144 TFIIH4, GTF2H4, TFB2 transcription initiation factor TFIIH subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03144 O70422 1220 1.6e-132 General transcription factor IIH subunit 4 OS=Mus musculus GN=Gtf2h4 PE=2 SV=1 PF03849 Transcription factor Tfb2 GO:0006289//GO:0006281//GO:0006355 nucleotide-excision repair//DNA repair//regulation of transcription, DNA-templated GO:0004003 ATP-dependent DNA helicase activity GO:0000439//GO:0005634//GO:0005657 core TFIIH complex//nucleus//replication fork KOG3471 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB2 Cluster-8309.1090 BF_2 51.00 1.99 1361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10901 BF_2 6.00 0.47 825 -- -- -- -- -- 768311753 CP010981.1 801 0 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- PF01213//PF02438//PF02209 Adenylate cyclase associated (CAP) N terminal//Late 100kD protein//Villin headpiece domain GO:0007010//GO:0019060 cytoskeleton organization//intracellular transport of viral protein in host cell GO:0003779 actin binding -- -- -- -- Cluster-8309.10903 BF_2 225.11 3.96 2668 300303952 ADJ97385.1 1183 1.2e-126 star [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42519 539 2.3e-53 Protein Star OS=Drosophila melanogaster GN=S PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10913 BF_2 3.10 0.75 459 642920133 XP_975457.2 147 2.7e-07 PREDICTED: NEDD4 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10923 BF_2 72.00 1.51 2284 189237424 XP_974277.2 1620 2.1e-177 PREDICTED: cGMP-dependent protein kinase 1-like [Tribolium castaneum] -- -- -- -- -- K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03042 1249 9.0e-136 cGMP-dependent protein kinase, isozyme 1 OS=Drosophila melanogaster GN=Pkg21D PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.10927 BF_2 3.00 0.35 645 662215753 XP_008481775.1 413 5.4e-38 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P04323 292 2.4e-25 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.10937 BF_2 11.00 0.42 1385 642938165 XP_008190990.1 263 2.9e-20 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.10940 BF_2 31.46 0.50 2918 270008647 EFA05095.1 800 3.3e-82 hypothetical protein TcasGA2_TC015194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 286 5.4e-24 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.10952 BF_2 124.26 0.83 6585 189234173 XP_968418.2 1427 1.4e-154 PREDICTED: RNA-binding protein Musashi homolog 2 isoform X2 [Tribolium castaneum] 642912293 XM_963325.3 503 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog 2 (LOC656824), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q96DH6 622 1.3e-62 RNA-binding protein Musashi homolog 2 OS=Homo sapiens GN=MSI2 PE=1 SV=1 PF00076//PF01692//PF16367//PF01213//PF01371//PF05014//PF08777//PF03852 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Paramyxovirus non-structural protein C//RNA recognition motif//Adenylate cyclase associated (CAP) N terminal//Trp repressor protein//Nucleoside 2-deoxyribosyltransferase//RNA binding motif//DNA mismatch endonuclease Vsr GO:0006355//GO:0006206//GO:0030683//GO:0007010//GO:0009159//GO:0006298 regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process//evasion or tolerance by virus of host immune response//cytoskeleton organization//deoxyribonucleoside monophosphate catabolic process//mismatch repair GO:0003700//GO:0003676//GO:0070694//GO:0003779//GO:0050144//GO:0004519//GO:0003723 transcription factor activity, sequence-specific DNA binding//nucleic acid binding//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//actin binding//nucleoside deoxyribosyltransferase activity//endonuclease activity//RNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.1096 BF_2 5.00 1.42 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10960 BF_2 4.00 0.33 797 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10970 BF_2 77.20 1.01 3499 642914820 XP_967881.3 1233 2.4e-132 PREDICTED: uncharacterized protein LOC656247 [Tribolium castaneum] 642914819 XM_962788.3 195 6.31865e-95 PREDICTED: Tribolium castaneum uncharacterized LOC656247 (LOC656247), mRNA -- -- -- -- P17789 361 1.3e-32 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF00215//PF02954//PF00126//PF10414//PF01381 BTB/POZ domain//Orotidine 5'-phosphate decarboxylase / HUMPS family//Bacterial regulatory protein, Fis family//Bacterial regulatory helix-turn-helix protein, lysR family//Sirohaem synthase dimerisation region//Helix-turn-helix GO:0006207//GO:0055114//GO:0006779//GO:0006355//GO:0006206 'de novo' pyrimidine nucleobase biosynthetic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0005515//GO:0003700//GO:0043565//GO:0004590 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//orotidine-5'-phosphate decarboxylase activity GO:0005667 transcription factor complex -- -- Cluster-8309.10974 BF_2 376.33 4.77 3587 817058456 XP_012250690.1 951 1.2e-99 PREDICTED: uncharacterized protein LOC105682992 isoform X3 [Athalia rosae]>gi|817058458|ref|XP_012250691.1| PREDICTED: uncharacterized protein LOC105682992 isoform X3 [Athalia rosae]>gi|817058460|ref|XP_012250692.1| PREDICTED: uncharacterized protein LOC105682992 isoform X3 [Athalia rosae] 642914678 XM_008192090.1 169 1.84011e-80 PREDICTED: Tribolium castaneum longitudinals lacking protein-like (LOC663115), mRNA -- -- -- -- P17789 361 1.3e-32 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00215//PF00651//PF10414//PF02954 Orotidine 5'-phosphate decarboxylase / HUMPS family//BTB/POZ domain//Sirohaem synthase dimerisation region//Bacterial regulatory protein, Fis family GO:0006779//GO:0055114//GO:0006206//GO:0006207 porphyrin-containing compound biosynthetic process//oxidation-reduction process//pyrimidine nucleobase metabolic process//'de novo' pyrimidine nucleobase biosynthetic process GO:0005515//GO:0004590//GO:0043565 protein binding//orotidine-5'-phosphate decarboxylase activity//sequence-specific DNA binding -- -- -- -- Cluster-8309.10975 BF_2 54.05 0.40 5875 642914820 XP_967881.3 887 5.3e-92 PREDICTED: uncharacterized protein LOC656247 [Tribolium castaneum] 642914819 XM_962788.3 98 8.90253e-41 PREDICTED: Tribolium castaneum uncharacterized LOC656247 (LOC656247), mRNA -- -- -- -- -- -- -- -- PF02954//PF10414 Bacterial regulatory protein, Fis family//Sirohaem synthase dimerisation region GO:0055114//GO:0006779 oxidation-reduction process//porphyrin-containing compound biosynthetic process GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.10978 BF_2 45.35 0.76 2774 189233854 XP_972406.2 1888 2.1e-208 PREDICTED: uncharacterized protein LOC661132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03220 Tombusvirus P19 core protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.10979 BF_2 132.83 2.22 2789 189233854 XP_972406.2 1893 5.7e-209 PREDICTED: uncharacterized protein LOC661132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03220 Tombusvirus P19 core protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.1098 BF_2 8.04 0.46 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.10983 BF_2 21.40 0.91 1266 357623407 EHJ74574.1 365 3.9e-32 dihydrouridine synthase domain containing protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01159//PF02944 Ribosomal protein L6e//BESS motif GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003677 structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.10993 BF_2 19.83 0.31 3006 167234210 NP_001107807.1 1867 6.3e-206 maxillopedia [Tribolium castaneum]>gi|270002809|gb|EEZ99256.1| proboscipedia [Tribolium castaneum] 347972356 XM_001688909.2 71 4.62539e-26 Anopheles gambiae str. PEST AGAP004648-PA (AgaP_AGAP004648) mRNA, complete cds K09302 HOX_2 homeobox protein HoxA/B2 http://www.genome.jp/dbget-bin/www_bget?ko:K09302 P31264 546 3.9e-54 Homeotic protein proboscipedia OS=Drosophila melanogaster GN=pb PE=2 SV=2 PF00507//PF07904//PF00046 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3//Chromatin modification-related protein EAF7//Homeobox domain GO:0006814//GO:0006355//GO:0006744//GO:0055114//GO:0015992//GO:0006120 sodium ion transport//regulation of transcription, DNA-templated//ubiquinone biosynthetic process//oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003677 NADH dehydrogenase (ubiquinone) activity//DNA binding GO:0005634//GO:0043189 nucleus//H4/H2A histone acetyltransferase complex -- -- Cluster-8309.11005 BF_2 25.00 0.90 1450 688549730 XP_009298900.1 474 1.0e-44 PREDICTED: gastrula zinc finger protein XlCGF57.1-like, partial [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96SE7 448 4.4e-43 Zinc finger protein 347 OS=Homo sapiens GN=ZNF347 PE=1 SV=2 PF13912//PF05864//PF16622//PF13465//PF00096//PF01155 C2H2-type zinc finger//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006351//GO:0006144//GO:0006206 cellular protein modification process//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0016151//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//nickel cation binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.11009 BF_2 6.06 0.55 751 242013607 XP_002427494.1 298 1.4e-24 Equilibrative nucleoside transporter, putative [Pediculus humanus corporis]>gi|212511889|gb|EEB14756.1| Equilibrative nucleoside transporter, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q9BZD2 219 8.1e-17 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.11010 BF_2 8.00 0.47 1004 156552507 XP_001602781.1 294 5.3e-24 PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis]>gi|645012566|ref|XP_008207864.1| PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q99808 157 1.7e-09 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.11020 BF_2 70.84 1.73 2003 675378821 KFM71723.1 515 2.5e-49 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 483 5.3e-47 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13465//PF00096//PF08675//PF01475//PF17123//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//RNA binding domain//Ferric uptake regulator family//RING-like zinc finger//C2H2-type zinc finger GO:0006402//GO:0006355//GO:0051252 mRNA catabolic process//regulation of transcription, DNA-templated//regulation of RNA metabolic process GO:0003723//GO:0005515//GO:0004535//GO:0008270//GO:0046872//GO:0003700 RNA binding//protein binding//poly(A)-specific ribonuclease activity//zinc ion binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005737 nucleus//transcription factor complex//cytoplasm -- -- Cluster-8309.11022 BF_2 59.51 0.87 3165 189234230 XP_973019.2 673 1.9e-67 PREDICTED: uncharacterized protein LOC661786 [Tribolium castaneum]>gi|270002409|gb|EEZ98856.1| hypothetical protein TcasGA2_TC004466 [Tribolium castaneum] -- -- -- -- -- K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83916 440 8.1e-42 Chromobox protein homolog 1 OS=Homo sapiens GN=CBX1 PE=1 SV=1 PF03119//PF02150//PF00130//PF01393//PF01096//PF01396//PF06160 NAD-dependent DNA ligase C4 zinc finger domain//RNA polymerases M/15 Kd subunit//Phorbol esters/diacylglycerol binding domain (C1 domain)//Chromo shadow domain//Transcription factor S-II (TFIIS)//Topoisomerase DNA binding C4 zinc finger//Septation ring formation regulator, EzrA GO:0006206//GO:0006144//GO:0000921//GO:0006351//GO:0035556//GO:0006265//GO:0006260//GO:0006281 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//septin ring assembly//transcription, DNA-templated//intracellular signal transduction//DNA topological change//DNA replication//DNA repair GO:0003676//GO:0003916//GO:0003677//GO:0003911//GO:0008270//GO:0003899 nucleic acid binding//DNA topoisomerase activity//DNA binding//DNA ligase (NAD+) activity//zinc ion binding//DNA-directed RNA polymerase activity GO:0005694//GO:0005634//GO:0005730//GO:0005940//GO:0016021 chromosome//nucleus//nucleolus//septin ring//integral component of membrane -- -- Cluster-8309.11028 BF_2 21.00 0.68 1578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00444 Ribosomal protein L36 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.11033 BF_2 40.00 1.60 1333 270008876 EFA05324.1 1244 4.9e-134 hypothetical protein TcasGA2_TC015488 [Tribolium castaneum] -- -- -- -- -- K01197 hya hyaluronoglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01197 Q08169 896 4.5e-95 Hyaluronidase OS=Apis mellifera PE=1 SV=1 PF01630 Hyaluronidase GO:0005975 carbohydrate metabolic process GO:0004415 hyalurononglucosaminidase activity -- -- -- -- Cluster-8309.11037 BF_2 105.25 1.89 2615 478262843 ENN81328.1 1387 2.5e-150 hypothetical protein YQE_02264, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9ULM3 518 6.0e-51 YEATS domain-containing protein 2 OS=Homo sapiens GN=YEATS2 PE=1 SV=2 PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.11039 BF_2 8.00 0.76 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11041 BF_2 44.00 1.41 1593 642936051 XP_008198282.1 1282 2.3e-138 PREDICTED: origin recognition complex subunit 5 [Tribolium castaneum]>gi|642936053|ref|XP_974215.2| PREDICTED: origin recognition complex subunit 5 [Tribolium castaneum]>gi|270014012|gb|EFA10460.1| hypothetical protein TcasGA2_TC012706 [Tribolium castaneum] -- -- -- -- -- K02607 ORC5 origin recognition complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02607 Q9WUV0 729 1.2e-75 Origin recognition complex subunit 5 OS=Mus musculus GN=Orc5 PE=2 SV=1 PF14630//PF00004 Origin recognition complex (ORC) subunit 5 C-terminus//ATPase family associated with various cellular activities (AAA) GO:0006260 DNA replication GO:0005524 ATP binding GO:0043229//GO:0005634//GO:0000808 intracellular organelle//nucleus//origin recognition complex KOG2543 Origin recognition complex, subunit 5 Cluster-8309.11056 BF_2 29.00 4.10 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11061 BF_2 123.00 2.36 2464 332373558 AEE61920.1 682 1.3e-68 unknown [Dendroctonus ponderosae]>gi|478261087|gb|ENN80642.1| hypothetical protein YQE_02929, partial [Dendroctonus ponderosae]>gi|546673882|gb|ERL85404.1| hypothetical protein D910_02824 [Dendroctonus ponderosae] -- -- -- -- -- K17790 TIM22 mitochondrial import inner membrane translocase subunit TIM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17790 Q8IN78 509 6.3e-50 Mitochondrial import inner membrane translocase subunit Tim22 OS=Drosophila melanogaster GN=Tim22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3225 Mitochondrial import inner membrane translocase, subunit TIM22 Cluster-8309.11062 BF_2 48.00 2.51 1086 91085453 XP_969413.1 599 2.5e-59 PREDICTED: mediator of RNA polymerase II transcription subunit 21 [Tribolium castaneum]>gi|270008396|gb|EFA04844.1| hypothetical protein TcasGA2_TC014894 [Tribolium castaneum] -- -- -- -- -- K15152 MED21, SRB7 mediator of RNA polymerase II transcription subunit 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15152 Q16RX1 477 1.4e-46 Mediator of RNA polymerase II transcription subunit 21 OS=Aedes aegypti GN=MED21 PE=3 SV=1 PF06152//PF04111//PF06100 Phage minor capsid protein 2//Autophagy protein Apg6//MCRA family GO:0006914//GO:0006631 autophagy//fatty acid metabolic process GO:0005198//GO:0050151//GO:0071949 structural molecule activity//oleate hydratase activity//FAD binding GO:0019028 viral capsid KOG1510 RNA polymerase II holoenzyme and mediator subcomplex, subunit SURB7/SRB7 Cluster-8309.11064 BF_2 93.87 1.41 3073 91081139 XP_975550.1 1584 4.2e-173 PREDICTED: uncharacterized protein LOC664451 [Tribolium castaneum]>gi|270005285|gb|EFA01733.1| hypothetical protein TcasGA2_TC007326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 140 4.8e-07 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF13851//PF10186//PF07058//PF16331//PF04977//PF04111//PF02050//PF17060//PF17078//PF00769//PF00038//PF02601//PF10473//PF08988//PF03938 Growth-arrest specific micro-tubule binding//Vacuolar sorting 38 and autophagy-related subunit 14//Microtubule-associated protein 70//TolA binding protein trimerisation//Septum formation initiator//Autophagy protein Apg6//Flagellar FliJ protein//Monopolar spindle protein 2//SWI5-dependent HO expression protein 3//Ezrin/radixin/moesin family//Intermediate filament protein//Exonuclease VII, large subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Type III secretion system, cytoplasmic E component of needle//Outer membrane protein (OmpH-like) GO:0006935//GO:0051028//GO:0071973//GO:0030474//GO:0048870//GO:0048309//GO:0007049//GO:0010508//GO:0009405//GO:0006914//GO:0007010//GO:0070206//GO:0071988//GO:0006308 chemotaxis//mRNA transport//bacterial-type flagellum-dependent cell motility//spindle pole body duplication//cell motility//endoplasmic reticulum inheritance//cell cycle//positive regulation of autophagy//pathogenesis//autophagy//cytoskeleton organization//protein trimerization//protein localization to spindle pole body//DNA catabolic process GO:0051082//GO:0008134//GO:0045502//GO:0003774//GO:0008092//GO:0005198//GO:0042803//GO:0008017//GO:0008855 unfolded protein binding//transcription factor binding//dynein binding//motor activity//cytoskeletal protein binding//structural molecule activity//protein homodimerization activity//microtubule binding//exodeoxyribonuclease VII activity GO:0009318//GO:0009288//GO:0019898//GO:0005882//GO:0045298//GO:0030286//GO:0005667//GO:0005737//GO:0031514//GO:0016020 exodeoxyribonuclease VII complex//bacterial-type flagellum//extrinsic component of membrane//intermediate filament//tubulin complex//dynein complex//transcription factor complex//cytoplasm//motile cilium//membrane -- -- Cluster-8309.11068 BF_2 18.00 0.69 1381 642937391 XP_008198818.1 447 1.3e-41 PREDICTED: carboxypeptidase N subunit 2-like [Tribolium castaneum]>gi|270001112|gb|EEZ97559.1| hypothetical protein TcasGA2_TC011413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5M3 245 1.4e-19 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.11070 BF_2 4.00 0.86 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11073 BF_2 4.11 0.35 780 642936195 XP_008198341.1 491 5.9e-47 PREDICTED: sp-like zinc finger transcription factor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11080 BF_2 23.00 0.46 2358 558131945 XP_006116544.1 459 9.1e-43 PREDICTED: LOW QUALITY PROTEIN: cell division cycle-associated protein 7 [Pelodiscus sinensis] -- -- -- -- -- -- -- -- -- Q9BWT1 429 1.1e-40 Cell division cycle-associated protein 7 OS=Homo sapiens GN=CDCA7 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11082 BF_2 31.87 0.71 2154 546676105 ERL87172.1 1153 2.8e-123 hypothetical protein D910_04572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7K175 535 5.3e-53 Small RNA 2'-O-methyltransferase OS=Drosophila melanogaster GN=Hen1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2 Cluster-8309.1109 BF_2 8.00 0.82 696 642914225 XP_008201597.1 978 1.8e-103 PREDICTED: ras-related protein Rab-8A [Tribolium castaneum] 768439325 XM_011562986.1 156 5.78473e-74 PREDICTED: Plutella xylostella ras-related protein Rab-8A (LOC105391505), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 Q5F470 522 5.5e-52 Ras-related protein Rab-8A OS=Gallus gallus GN=RAB8A PE=2 SV=1 PF01637//PF04042//PF04670//PF00071//PF01926//PF00735//PF08477//PF00025//PF02421//PF00004 Archaeal ATPase//DNA polymerase alpha/epsilon subunit B//Gtr1/RagA G protein conserved region//Ras family//50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B//ATPase family associated with various cellular activities (AAA) GO:0015684//GO:0007264//GO:0006260 ferrous iron transport//small GTPase mediated signal transduction//DNA replication GO:0005525//GO:0003887//GO:0003677//GO:0005524//GO:0015093 GTP binding//DNA-directed DNA polymerase activity//DNA binding//ATP binding//ferrous iron transmembrane transporter activity GO:0042575//GO:0016021 DNA polymerase complex//integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.11090 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11092 BF_2 37.92 0.71 2507 478258022 ENN78160.1 269 1.0e-20 hypothetical protein YQE_05314, partial [Dendroctonus ponderosae]>gi|546682522|gb|ERL92445.1| hypothetical protein D910_09759 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04159 NB glycoprotein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11095 BF_2 16.05 0.68 1270 642919435 XP_008191868.1 407 5.3e-37 PREDICTED: uncharacterized protein LOC663349 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11104 BF_2 17.00 0.35 2322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11123 BF_2 1.71 0.44 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11129 BF_2 75.00 4.38 1004 389609203 BAM18213.1 918 2.3e-96 purine nucleoside phosphorylase [Papilio xuthus] -- -- -- -- -- K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P55859 747 6.4e-78 Purine nucleoside phosphorylase OS=Bos taurus GN=PNP PE=1 SV=3 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.11130 BF_2 64.00 1.32 2309 861625527 KMQ88569.1 514 3.8e-49 retrovirus-like pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 176 2.4e-11 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.11131 BF_2 42.77 0.74 2719 167234455 NP_001107843.1 1160 5.5e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.5e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11132 BF_2 74.00 1.72 2087 642920631 XP_008192495.1 204 3.0e-13 PREDICTED: uncharacterized protein LOC103312786 [Tribolium castaneum]>gi|270006078|gb|EFA02526.1| hypothetical protein TcasGA2_TC008231 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11134 BF_2 3.00 1.04 407 589960858 XP_006993004.1 597 1.6e-59 PREDICTED: 60S ribosomal protein L27 [Peromyscus maniculatus bairdii] 694966814 XM_001159277.4 407 0 PREDICTED: Pan troglodytes ribosomal protein L27 (RPL27), mRNA K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 P61354 583 2.7e-59 60S ribosomal protein L27 OS=Rattus norvegicus GN=Rpl27 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3418 60S ribosomal protein L27 Cluster-8309.11139 BF_2 34.78 1.91 1049 642929434 XP_008195838.1 799 1.5e-82 PREDICTED: transcription initiation factor TFIID subunit 8-like [Tribolium castaneum]>gi|270010530|gb|EFA06978.1| hypothetical protein TcasGA2_TC009938 [Tribolium castaneum] -- -- -- -- -- K14649 TAF8 transcription initiation factor TFIID subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14649 Q9VWY6 442 1.6e-42 Transcription initiation factor TFIID subunit 8 OS=Drosophila melanogaster GN=Taf8 PE=1 SV=1 PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.11140 BF_2 75.00 0.50 6554 189236209 XP_971084.2 7938 0.0e+00 PREDICTED: cadherin-related tumor suppressor [Tribolium castaneum] -- -- -- -- -- K16669 FAT4 protocadherin Fat 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16669 P33450 6028 0.0e+00 Cadherin-related tumor suppressor OS=Drosophila melanogaster GN=ft PE=1 SV=3 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.11151 BF_2 27.75 0.33 3779 642936806 XP_008199624.1 2898 0.0e+00 PREDICTED: protein sickie isoform X2 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 4.2e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF01443//PF03796//PF06156//PF01695//PF07728//PF08172//PF00004//PF13851//PF02562//PF09726//PF03836//PF08702//PF00910//PF00769 Viral (Superfamily 1) RNA helicase//DnaB-like helicase C terminal domain//Protein of unknown function (DUF972)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//CASP C terminal//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//PhoH-like protein//Transmembrane protein//RasGAP C-terminus//Fibrinogen alpha/beta chain family//RNA helicase//Ezrin/radixin/moesin family GO:0051258//GO:0007165//GO:0006260//GO:0048870//GO:0006891//GO:0007264//GO:0030168 protein polymerization//signal transduction//DNA replication//cell motility//intra-Golgi vesicle-mediated transport//small GTPase mediated signal transduction//platelet activation GO:0005096//GO:0005524//GO:0005102//GO:0016887//GO:0003678//GO:0008092//GO:0003723//GO:0003724//GO:0030674 GTPase activator activity//ATP binding//receptor binding//ATPase activity//DNA helicase activity//cytoskeletal protein binding//RNA binding//RNA helicase activity//protein binding, bridging GO:0031514//GO:0016021//GO:0019898//GO:0005577//GO:0005737//GO:0005657//GO:0030173 motile cilium//integral component of membrane//extrinsic component of membrane//fibrinogen complex//cytoplasm//replication fork//integral component of Golgi membrane -- -- Cluster-8309.11152 BF_2 27.00 0.55 2334 675379989 KFM72891.1 1125 5.4e-120 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q96DM1 678 1.5e-69 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11159 BF_2 38.45 0.78 2348 478253706 ENN74005.1 643 4.2e-64 hypothetical protein YQE_09395, partial [Dendroctonus ponderosae]>gi|546678195|gb|ERL88885.1| hypothetical protein D910_06267 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 284 7.3e-24 Brachyurin OS=Uca pugilator PE=1 SV=2 PF04111//PF05837//PF02477//PF00089//PF10186 Autophagy protein Apg6//Centromere protein H (CENP-H)//Nucleocapsid N protein//Trypsin//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006508//GO:0051382//GO:0006914//GO:0010508 proteolysis//kinetochore assembly//autophagy//positive regulation of autophagy GO:0004252 serine-type endopeptidase activity GO:0000776//GO:0019013 kinetochore//viral nucleocapsid -- -- Cluster-8309.11170 BF_2 25.63 1.30 1114 642914939 XP_008190450.1 330 3.9e-28 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q1LXK5 228 1.1e-17 Putative helicase mov-10-B.2 OS=Danio rerio GN=mov10b.2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.11185 BF_2 62.00 2.33 1401 546673408 ERL85020.1 274 1.5e-21 hypothetical protein D910_02443 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.11191 BF_2 117.05 3.80 1577 91080979 XP_974925.1 843 1.8e-87 PREDICTED: uncharacterized protein LOC663797 [Tribolium castaneum]>gi|270005969|gb|EFA02417.1| hypothetical protein TcasGA2_TC008102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11195 BF_2 3.00 0.37 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11199 BF_2 5.00 0.81 544 546682479 ERL92402.1 418 1.2e-38 hypothetical protein D910_09716 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 315 4.3e-28 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF03283 Pectinacetylesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.11200 BF_2 15.19 0.35 2121 676433751 XP_009047002.1 461 4.8e-43 hypothetical protein LOTGIDRAFT_54048, partial [Lottia gigantea]>gi|556113642|gb|ESP02294.1| hypothetical protein LOTGIDRAFT_54048, partial [Lottia gigantea] -- -- -- -- -- K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O14672 369 9.2e-34 Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens GN=ADAM10 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.11202 BF_2 7.19 0.78 675 642927339 XP_008195226.1 215 5.1e-15 PREDICTED: uncharacterized protein LOC103313529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11207 BF_2 69.16 3.20 1191 270010184 EFA06632.1 1039 2.6e-110 hypothetical protein TcasGA2_TC009552 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.11214 BF_2 48.28 0.72 3092 478260277 ENN80029.1 3743 0.0e+00 hypothetical protein YQE_03506, partial [Dendroctonus ponderosae] 749790992 XM_011150385.1 111 2.76483e-48 PREDICTED: Harpegnathos saltator DNA replication licensing factor MCM4 (LOC105188757), transcript variant X3, mRNA K02212 MCM4, CDC54 DNA replication licensing factor MCM4 http://www.genome.jp/dbget-bin/www_bget?ko:K02212 Q26454 3318 0.0e+00 DNA replication licensing factor MCM4 OS=Drosophila melanogaster GN=dpa PE=1 SV=2 PF05460//PF00493//PF07726//PF00004//PF13545//PF05669//PF00158//PF07728 Origin recognition complex subunit 6 (ORC6)//MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//ATPase family associated with various cellular activities (AAA)//Crp-like helix-turn-helix domain//SOH1//Sigma-54 interaction domain//AAA domain (dynein-related subfamily) GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008134//GO:0001104//GO:0003677//GO:0005524//GO:0016887 transcription factor binding//RNA polymerase II transcription cofactor activity//DNA binding//ATP binding//ATPase activity GO:0005664//GO:0005667//GO:0016592 nuclear origin of replication recognition complex//transcription factor complex//mediator complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.11223 BF_2 64.83 0.44 6494 91090584 XP_972498.1 2433 3.2e-271 PREDICTED: histone H2A deubiquitinase MYSM1 isoform X1 [Tribolium castaneum]>gi|270013339|gb|EFA09787.1| hypothetical protein TcasGA2_TC011929 [Tribolium castaneum] -- -- -- -- -- K11865 MYSM1 protein MYSM1 http://www.genome.jp/dbget-bin/www_bget?ko:K11865 Q5RGA4 642 6.2e-65 Histone H2A deubiquitinase MYSM1 OS=Danio rerio GN=mysm1 PE=2 SV=2 PF02347//PF01053//PF00155//PF04433//PF01398 Glycine cleavage system P-protein//Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II//SWIRM domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006563//GO:0055114//GO:0006544//GO:0006546//GO:0009058//GO:0006566 L-serine metabolic process//oxidation-reduction process//glycine metabolic process//glycine catabolic process//biosynthetic process//threonine metabolic process GO:0030170//GO:0005515//GO:0005488//GO:0004375 pyridoxal phosphate binding//protein binding//binding//glycine dehydrogenase (decarboxylating) activity -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.11226 BF_2 18.00 1.97 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11228 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11236 BF_2 94.33 3.65 1369 332372666 AEE61475.1 568 1.2e-55 unknown [Dendroctonus ponderosae]>gi|546681209|gb|ERL91344.1| hypothetical protein D910_08676 [Dendroctonus ponderosae] -- -- -- -- -- K17259 CIB1 calcium and integrin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17259 Q17QE5 251 2.9e-20 Calcium and integrin-binding protein 1 OS=Bos taurus GN=CIB1 PE=2 SV=1 PF01640//PF13499//PF00036//PF13833//PF13405 Peptidase C10 family//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain GO:0006508 proteolysis GO:0005509//GO:0008234 calcium ion binding//cysteine-type peptidase activity -- -- KOG0038 Ca2+-binding kinase interacting protein (KIP) (EF-Hand protein superfamily) Cluster-8309.11237 BF_2 99.67 3.58 1452 332372666 AEE61475.1 568 1.3e-55 unknown [Dendroctonus ponderosae]>gi|546681209|gb|ERL91344.1| hypothetical protein D910_08676 [Dendroctonus ponderosae] -- -- -- -- -- K17259 CIB1 calcium and integrin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17259 Q17QE5 251 3.0e-20 Calcium and integrin-binding protein 1 OS=Bos taurus GN=CIB1 PE=2 SV=1 PF01640//PF13499//PF13833//PF00036//PF13405 Peptidase C10 family//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain GO:0006508 proteolysis GO:0005509//GO:0008234 calcium ion binding//cysteine-type peptidase activity -- -- KOG0038 Ca2+-binding kinase interacting protein (KIP) (EF-Hand protein superfamily) Cluster-8309.1124 BF_2 3.00 0.35 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.11251 BF_2 4.00 0.71 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11252 BF_2 12.00 0.87 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11253 BF_2 1.00 0.93 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11254 BF_2 101.00 1.85 2571 642921297 XP_008192807.1 2482 2.6e-277 PREDICTED: spermatogenesis-associated protein 5 [Tribolium castaneum] 294939026 XM_002782252.1 35 4.06413e-06 Perkinsus marinus ATCC 50983 cell division cycle protein 48, putative, mRNA K14575 AFG2, DRG1, SPATA5 AAA family ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14575 Q8NB90 1328 7.0e-145 Spermatogenesis-associated protein 5 OS=Homo sapiens GN=SPATA5 PE=1 SV=3 PF07726//PF03193//PF00005//PF00270//PF10662//PF00910//PF14532//PF06068//PF05496//PF00437//PF07724//PF02367//PF06414//PF02562//PF07728//PF01745//PF01695//PF00158//PF00004 ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//DEAD/DEAH box helicase//Ethanolamine utilisation - propanediol utilisation//RNA helicase//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein//AAA domain (dynein-related subfamily)//Isopentenyl transferase//IstB-like ATP binding protein//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA) GO:0006355//GO:0006694//GO:0009058//GO:0016114//GO:0006810//GO:0006281//GO:0002949//GO:0006310//GO:0006576 regulation of transcription, DNA-templated//steroid biosynthetic process//biosynthetic process//terpenoid biosynthetic process//transport//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//cellular biogenic amine metabolic process GO:0016301//GO:0004161//GO:0016887//GO:0005524//GO:0003924//GO:0008134//GO:0005525//GO:0003676//GO:0009378//GO:0003724//GO:0003678//GO:0003723 kinase activity//dimethylallyltranstransferase activity//ATPase activity//ATP binding//GTPase activity//transcription factor binding//GTP binding//nucleic acid binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0730 AAA+-type ATPase Cluster-8309.11258 BF_2 31.00 0.56 2615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11260 BF_2 10.00 0.35 1486 642929412 XP_008195828.1 578 9.2e-57 PREDICTED: uncharacterized protein LOC663405 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00015 Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165 signal transduction GO:0004871 signal transducer activity GO:0016020 membrane -- -- Cluster-8309.11262 BF_2 108.00 3.66 1521 546678561 ERL89150.1 531 2.6e-51 hypothetical protein D910_06526 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P52746 214 6.2e-16 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF10018//PF00096//PF04988//PF02150 Vitamin-D-receptor interacting Mediator subunit 4//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//RNA polymerases M/15 Kd subunit GO:0006357//GO:0006206//GO:0006144//GO:0006351 regulation of transcription from RNA polymerase II promoter//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003899//GO:0001104//GO:0003677 metal ion binding//DNA-directed RNA polymerase activity//RNA polymerase II transcription cofactor activity//DNA binding GO:0005730//GO:0005634//GO:0016592 nucleolus//nucleus//mediator complex KOG1721 FOG: Zn-finger Cluster-8309.11263 BF_2 17.00 0.80 1174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11265 BF_2 3.00 0.54 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11267 BF_2 6.07 0.56 739 826407466 XP_012543053.1 167 2.1e-09 PREDICTED: zinc finger protein 184-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- P42283 137 2.6e-07 Longitudinals lacking protein, isoform G OS=Drosophila melanogaster GN=lola PE=1 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.11268 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11271 BF_2 10.00 1.18 642 189236047 XP_001809216.1 272 1.2e-21 PREDICTED: uncharacterized protein LOC100142481 [Tribolium castaneum]>gi|270006406|gb|EFA02854.1| hypothetical protein TcasGA2_TC007737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.11272 BF_2 2.00 0.31 554 119623651 EAX03246.1 184 1.7e-11 major histocompatibility complex, class I, A, isoform CRA_g [Homo sapiens] 768052561 XM_011548124.1 550 0 PREDICTED: Homo sapiens major histocompatibility complex, class I, A (HLA-A), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF06623 MHC_I C-terminus GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- -- -- -- -- Cluster-8309.11274 BF_2 3.00 0.99 413 820987688 XP_012362358.1 715 3.3e-73 PREDICTED: translationally-controlled tumor protein isoform X3 [Nomascus leucogenys] 694911845 XM_001139202.4 404 0 PREDICTED: Pan troglodytes translationally-controlled tumor protein (LOC735922), mRNA -- -- -- -- P13693 715 1.4e-74 Translationally-controlled tumor protein OS=Homo sapiens GN=TPT1 PE=1 SV=1 PF03945 delta endotoxin, N-terminal domain GO:0009405 pathogenesis -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.11281 BF_2 5.00 0.31 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11287 BF_2 120.00 2.87 2039 646708587 KDR14836.1 553 1.0e-53 hypothetical protein L798_11281 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q09415 135 1.2e-06 SET domain-containing protein 14 OS=Caenorhabditis elegans GN=set-14 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.11300 BF_2 5.00 0.71 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11303 BF_2 9.39 0.92 712 478255596 ENN75810.1 165 3.4e-09 hypothetical protein YQE_07646, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.11312 BF_2 27.00 0.34 3616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00473 Corticotropin-releasing factor family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.11314 BF_2 15.00 0.67 1223 546678917 ERL89455.1 159 2.9e-08 hypothetical protein D910_06822 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11318 BF_2 24.00 1.39 1011 642939603 XP_008194617.1 625 2.2e-62 PREDICTED: uncharacterized protein LOC103313343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13508 Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.11335 BF_2 109.00 1.12 4355 754353308 XP_004342494.2 819 3.0e-84 tyrosine-protein kinase Src42A [Capsaspora owczarzaki ATCC 30864]>gi|765557992|gb|KJE98246.1| TKL protein kinase [Capsaspora owczarzaki ATCC 30864] -- -- -- -- -- -- -- -- -- P12024 397 1.1e-36 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF07649//PF00560//PF13855 C1-like domain//Leucine Rich Repeat//Leucine rich repeat GO:0055114 oxidation-reduction process GO:0047134//GO:0005515 protein-disulfide reductase activity//protein binding -- -- -- -- Cluster-8309.11337 BF_2 24.00 1.58 923 478252342 ENN72768.1 269 3.8e-21 hypothetical protein YQE_10573, partial [Dendroctonus ponderosae]>gi|546680676|gb|ERL90902.1| hypothetical protein D910_08247 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11349 BF_2 11.00 0.65 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11361 BF_2 15.00 0.34 2135 620981748 XP_001515708.3 3451 0.0e+00 PREDICTED: elongation factor 2 [Ornithorhynchus anatinus] 83656775 NM_001961.3 2132 0 Homo sapiens eukaryotic translation elongation factor 2 (EEF2), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q5R8Z3 3433 0.0e+00 Elongation factor 2 OS=Pongo abelii GN=EEF2 PE=2 SV=3 PF03764//PF03144//PF01926 Elongation factor G, domain IV//Elongation factor Tu domain 2//50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.11363 BF_2 10.00 0.57 1026 852768041 XP_012878234.1 932 5.6e-98 PREDICTED: elongation factor 2 [Dipodomys ordii] 19353008 BC024689.1 1026 0 Homo sapiens, Similar to Elongation factor 2b, clone IMAGE:4153410, mRNA, partial cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 P13639 932 2.3e-99 Elongation factor 2 OS=Homo sapiens GN=EEF2 PE=1 SV=4 PF03764 Elongation factor G, domain IV -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.11369 BF_2 58.90 1.32 2156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16990 Carbohydrate binding module (family 35) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.11372 BF_2 9.00 0.49 1056 270005481 EFA01929.1 1133 2.9e-121 hypothetical protein TcasGA2_TC007543 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 641 1.3e-65 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF14565 Interleukin 22 IL-10-related T-cell-derived-inducible factor -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.11374 BF_2 0.89 0.91 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11377 BF_2 49.30 1.48 1679 478250371 ENN70866.1 996 3.5e-105 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672861|gb|ERL84584.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 625 1.5e-63 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF00975//PF07859//PF02230//PF00326//PF01764 Thioesterase domain//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3) GO:0006629//GO:0009058//GO:0006508//GO:0008152 lipid metabolic process//biosynthetic process//proteolysis//metabolic process GO:0008236//GO:0016787//GO:0016788 serine-type peptidase activity//hydrolase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.11378 BF_2 9.00 0.82 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03131 bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.11379 BF_2 6.00 0.47 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11380 BF_2 75.57 0.61 5464 642927353 XP_008195233.1 3614 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TE60 682 1.2e-69 A disintegrin and metalloproteinase with thrombospondin motifs 18 OS=Homo sapiens GN=ADAMTS18 PE=1 SV=3 PF01421//PF15339//PF01562//PF00413 Reprolysin (M12B) family zinc metalloprotease//Acrosome formation-associated factor//Reprolysin family propeptide//Matrixin GO:0006897//GO:0007342//GO:0060478//GO:0006508 endocytosis//fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis//proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012//GO:0005886 extracellular matrix//plasma membrane KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.11387 BF_2 3.18 0.42 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11398 BF_2 2.00 0.35 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11399 BF_2 69.08 0.84 3729 270017202 EFA13648.1 1715 3.3e-188 hypothetical protein TcasGA2_TC015886 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 184 4.6e-12 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00589//PF00075//PF05869//PF13495 Phage integrase family//RNase H//DNA N-6-adenine-methyltransferase (Dam)//Phage integrase, N-terminal SAM-like domain GO:0006306//GO:0051252//GO:0015074//GO:0006310//GO:0032775 DNA methylation//regulation of RNA metabolic process//DNA integration//DNA recombination//DNA methylation on adenine GO:0009007//GO:0004523//GO:0003676//GO:0003677 site-specific DNA-methyltransferase (adenine-specific) activity//RNA-DNA hybrid ribonuclease activity//nucleic acid binding//DNA binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.11400 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04049//PF03526 Anaphase promoting complex subunit 8 / Cdc23//Colicin E1 (microcin) immunity protein GO:0030071//GO:0006955//GO:0030153 regulation of mitotic metaphase/anaphase transition//immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814//GO:0005680 immunoglobulin complex//anaphase-promoting complex -- -- Cluster-8309.11406 BF_2 2.00 2.21 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11417 BF_2 63.00 0.55 5100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11421 BF_2 9.00 0.34 1401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11426 BF_2 3.00 0.54 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11427 BF_2 51.52 1.18 2111 332373864 AEE62073.1 1625 5.1e-178 unknown [Dendroctonus ponderosae]>gi|546671405|gb|ERL83730.1| hypothetical protein D910_00943 [Dendroctonus ponderosae]>gi|546673035|gb|ERL84721.1| hypothetical protein D910_02146 [Dendroctonus ponderosae]>gi|546675548|gb|ERL86721.1| hypothetical protein D910_04127 [Dendroctonus ponderosae] 817192520 XM_012416276.1 150 3.92553e-70 PREDICTED: Orussus abietinus uncharacterized LOC105695047 (LOC105695047), transcript variant X5, mRNA K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 P48544 859 1.4e-90 G protein-activated inward rectifier potassium channel 4 OS=Homo sapiens GN=KCNJ5 PE=1 SV=2 PF03845//PF01007 Spore germination protein//Inward rectifier potassium channel GO:0006813//GO:0009847 potassium ion transport//spore germination GO:0005242 inward rectifier potassium channel activity GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.11429 BF_2 36.55 0.48 3475 189234553 XP_973928.2 1623 1.4e-177 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] 571543566 XM_006559674.1 150 6.50079e-70 PREDICTED: Apis mellifera putative homeodomain transcription factor-like (LOC551885), mRNA -- -- -- -- Q9V9A8 918 3.3e-97 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.1143 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06756 Chorion protein S19 C-terminal GO:0007275 multicellular organismal development -- -- GO:0042600 chorion -- -- Cluster-8309.11431 BF_2 145.19 1.78 3691 642917889 XP_008191371.1 1666 1.6e-182 PREDICTED: regulator of chromosome condensation [Tribolium castaneum]>gi|642917891|ref|XP_008191372.1| PREDICTED: regulator of chromosome condensation [Tribolium castaneum] -- -- -- -- -- K11493 RCC1 regulator of chromosome condensation http://www.genome.jp/dbget-bin/www_bget?ko:K11493 P25183 874 4.4e-92 Regulator of chromosome condensation OS=Xenopus laevis GN=rcc1 PE=2 SV=1 PF01405//PF03989 Photosystem II reaction centre T protein//DNA gyrase C-terminal domain, beta-propeller GO:0015979//GO:0006265 photosynthesis//DNA topological change GO:0005524//GO:0003677//GO:0003916 ATP binding//DNA binding//DNA topoisomerase activity GO:0016020//GO:0005694//GO:0009539//GO:0009523 membrane//chromosome//photosystem II reaction center//photosystem II KOG1426 FOG: RCC1 domain Cluster-8309.11438 BF_2 77.00 5.75 847 91078752 XP_968271.1 858 1.8e-89 PREDICTED: U1 small nuclear ribonucleoprotein A [Tribolium castaneum]>gi|270003743|gb|EFA00191.1| hypothetical protein TcasGA2_TC003016 [Tribolium castaneum] 259016064 GQ265634.1 104 5.73002e-45 Muscidifurax raptorellus voucher NCSU:BMW DTOL-803 sans fille (SNF) mRNA, partial cds K11094 SNRPB2 U2 small nuclear ribonucleoprotein B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11094 P43332 710 1.1e-73 U1 small nuclear ribonucleoprotein A OS=Drosophila melanogaster GN=snf PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0000398 mRNA splicing, via spliceosome GO:0000166//GO:0003676//GO:0017069 nucleotide binding//nucleic acid binding//snRNA binding -- -- KOG4206 Spliceosomal protein snRNP-U1A/U2B Cluster-8309.11439 BF_2 1.00 1.03 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11440 BF_2 4.00 0.37 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11441 BF_2 28.37 1.98 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11444 BF_2 4.00 0.62 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11446 BF_2 178.68 7.14 1334 642917316 XP_008199250.1 1156 7.8e-124 PREDICTED: uncharacterized protein LOC103314598 [Tribolium castaneum]>gi|270004734|gb|EFA01182.1| hypothetical protein TcasGA2_TC010507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03595 Voltage-dependent anion channel GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11453 BF_2 3.00 0.40 602 270006771 EFA03219.1 510 2.8e-49 hypothetical protein TcasGA2_TC013139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 289 4.9e-25 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.11457 BF_2 21.40 0.50 2088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11459 BF_2 112.46 3.06 1826 728418532 AIY68372.1 1105 8.7e-118 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 637 6.7e-65 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859//PF02230 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.11462 BF_2 7.00 0.91 610 545808738 XP_003123559.3 984 3.1e-104 PREDICTED: 60S ribosomal protein L18a isoformX1 [Sus scrofa]>gi|675970145|pdb|4W20|S Chain S, Structure Of The Mammalian 60s Ribosomal Subunit (this Entry Contains The Large Ribosomal Proteins)>gi|675970196|pdb|4W22|S Chain S, Structure Of The 80s Mammalian Ribosome Bound To Eef2 (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970287|pdb|4W25|S Chain S, Structure Of The Idle Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970340|pdb|4W27|S Chain S, Structure Of The Translating Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins) 395132441 NM_000980.3 610 0 Homo sapiens ribosomal protein L18a (RPL18A), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q3T003 950 1.1e-101 60S ribosomal protein L18a OS=Bos taurus GN=RPL18A PE=2 SV=1 PF01775 Ribosomal L18ae/LX protein domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.11463 BF_2 1.00 0.65 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11469 BF_2 6.00 0.63 683 635137880 XP_008015806.1 924 3.2e-97 PREDICTED: 60S ribosomal protein L9 [Chlorocebus sabaeus] 589908438 NG_002468.5 683 0 Homo sapiens ribosomal protein L9 pseudogene 8 (RPL9P8) on chromosome 15 K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 P32969 906 1.6e-96 60S ribosomal protein L9 OS=Homo sapiens GN=RPL9 PE=1 SV=1 PF00347 Ribosomal protein L6 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-8309.11474 BF_2 3.00 0.44 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11475 BF_2 107.00 3.39 1606 642928982 XP_972386.2 1344 1.5e-145 PREDICTED: myrosinase 1-like [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1118 9.8e-121 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.11479 BF_2 45.00 3.55 818 675370342 KFM63244.1 206 6.9e-14 THAP domain-containing protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF04037//PF15898//PF02183 THAP domain//Domain of unknown function (DUF382)//cGMP-dependent protein kinase interacting domain//Homeobox associated leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0019901//GO:0003676 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein kinase binding//nucleic acid binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.1148 BF_2 10.00 0.75 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11484 BF_2 76.17 1.94 1928 91079546 XP_971272.1 196 2.3e-12 PREDICTED: uncharacterized protein LOC659913 [Tribolium castaneum]>gi|270003419|gb|EEZ99866.1| hypothetical protein TcasGA2_TC002648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10717//PF03505 Occlusion-derived virus envelope protein ODV-E18//Clostridium enterotoxin GO:0009405 pathogenesis -- -- GO:0005576//GO:0019031 extracellular region//viral envelope -- -- Cluster-8309.11487 BF_2 32.30 2.22 895 642918693 XP_008191540.1 730 1.3e-74 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 172 2.7e-11 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11489 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1149 BF_2 30.00 5.71 507 328899750 AEB54647.1 650 1.4e-65 ribosomal protein S18 [Procambarus clarkii]>gi|717007033|gb|AIW68599.1| ribosomal protein S18 [Cherax quadricarinatus] 328899749 HQ414569.1 264 3.80602e-134 Procambarus clarkii clone pc-273 ribosomal protein S18 mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q8ISP0 603 1.6e-61 40S ribosomal protein S18 OS=Branchiostoma belcheri GN=RPS18 PE=2 SV=1 PF00416//PF06831 Ribosomal protein S13/S18//Formamidopyrimidine-DNA glycosylase H2TH domain GO:0042254//GO:0006289//GO:0006412//GO:0006281//GO:0006284 ribosome biogenesis//nucleotide-excision repair//translation//DNA repair//base-excision repair GO:0003684//GO:0008270//GO:0003735//GO:0003906//GO:0003723//GO:0016799 damaged DNA binding//zinc ion binding//structural constituent of ribosome//DNA-(apurinic or apyrimidinic site) lyase activity//RNA binding//hydrolase activity, hydrolyzing N-glycosyl compounds GO:0005840//GO:0005622 ribosome//intracellular KOG3311 Ribosomal protein S18 Cluster-8309.11497 BF_2 131.15 1.82 3310 546679820 ERL90212.1 1294 1.9e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP2 823 3.3e-86 Histone H4 transcription factor OS=Bos taurus GN=HINFP PE=2 SV=1 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.11502 BF_2 19.00 0.40 2254 675748704 XP_008970133.1 2708 1.4e-303 PREDICTED: pyruvate kinase PKM isoform X4 [Pan paniscus]>gi|694960400|ref|XP_009427758.1| PREDICTED: pyruvate kinase PKM isoform X6 [Pan troglodytes]>gi|767984414|ref|XP_011519973.1| PREDICTED: pyruvate kinase PKM isoform X5 [Homo sapiens]>gi|119598293|gb|EAW77887.1| pyruvate kinase, muscle, isoform CRA_d [Homo sapiens] 767984411 XM_011521670.1 2254 0 PREDICTED: Homo sapiens pyruvate kinase, muscle (PKM), transcript variant X3, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 P14618 2715 9.1e-306 Pyruvate kinase PKM OS=Homo sapiens GN=PKM PE=1 SV=4 PF03328//PF00478//PF00224 HpcH/HpaI aldolase/citrate lyase family//IMP dehydrogenase / GMP reductase domain//Pyruvate kinase, barrel domain GO:0001889//GO:0006096//GO:0032868//GO:0055114//GO:0006754//GO:0043403//GO:0006094//GO:0012501//GO:0006144//GO:0014870//GO:0001666//GO:0007584//GO:0042866//GO:0031100//GO:0009629//GO:0015976 liver development//glycolytic process//response to insulin//oxidation-reduction process//ATP biosynthetic process//skeletal muscle tissue regeneration//gluconeogenesis//programmed cell death//purine nucleobase metabolic process//response to muscle inactivity//response to hypoxia//response to nutrient//pyruvate biosynthetic process//organ regeneration//response to gravity//carbon utilization GO:0005524//GO:0043531//GO:0004743//GO:0005515//GO:0003824//GO:0030955//GO:0000287 ATP binding//ADP binding//pyruvate kinase activity//protein binding//catalytic activity//potassium ion binding//magnesium ion binding GO:0005739//GO:0070062//GO:0019861//GO:0005829//GO:0005634//GO:0005886 mitochondrion//extracellular exosome//obsolete flagellum//cytosol//nucleus//plasma membrane KOG2323 Pyruvate kinase Cluster-8309.11503 BF_2 35.00 0.50 3201 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11506 BF_2 13.00 0.35 1857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00511 E2 (early) protein, C terminal GO:0006275//GO:0006355 regulation of DNA replication//regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex -- -- Cluster-8309.11511 BF_2 18.84 0.40 2261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11514 BF_2 146.00 2.24 3014 270002841 EEZ99288.1 2179 4.2e-242 van-gogh [Tribolium castaneum] -- -- -- -- -- K04510 VANGL vang-like http://www.genome.jp/dbget-bin/www_bget?ko:K04510 Q91ZD4 1040 2.0e-111 Vang-like protein 2 OS=Mus musculus GN=Vangl2 PE=1 SV=3 PF06638 Strabismus protein GO:0007275 multicellular organismal development -- -- GO:0016021 integral component of membrane KOG3814 Signaling protein van gogh/strabismus Cluster-8309.11515 BF_2 22.84 0.46 2378 282158079 NP_001164083.1 1656 1.5e-181 transcription factor AP-2 [Tribolium castaneum] 597797984 XM_007260483.1 100 2.76242e-42 PREDICTED: Astyanax mexicanus transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (tfap2b), mRNA K09179 TFAP2E transcription factor AP-2 epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09179 Q2T9K2 867 1.9e-91 Transcription factor AP-2-epsilon OS=Xenopus laevis GN=tfap2e PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3811 Transcription factor AP-2 Cluster-8309.11516 BF_2 16.93 0.46 1826 642929144 XP_008195712.1 1743 9.2e-192 PREDICTED: transcription factor AP-2 isoform X2 [Tribolium castaneum] 597797984 XM_007260483.1 100 2.11161e-42 PREDICTED: Astyanax mexicanus transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (tfap2b), mRNA K09179 TFAP2E transcription factor AP-2 epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09179 Q2T9K2 867 1.4e-91 Transcription factor AP-2-epsilon OS=Xenopus laevis GN=tfap2e PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3811 Transcription factor AP-2 Cluster-8309.11521 BF_2 74.00 2.74 1418 189234647 XP_001808029.1 740 1.4e-75 PREDICTED: DNA fragmentation factor subunit alpha [Tribolium castaneum]>gi|270001621|gb|EEZ98068.1| hypothetical protein TcasGA2_TC000475 [Tribolium castaneum] 642914004 XM_001807977.2 155 4.34518e-73 PREDICTED: Tribolium castaneum DNA fragmentation factor subunit alpha (LOC655663), mRNA -- -- -- -- O70303 192 2.1e-13 Cell death activator CIDE-B OS=Mus musculus GN=Cideb PE=1 SV=2 PF02017 CIDE-N domain GO:0006915 apoptotic process -- -- GO:0005622 intracellular -- -- Cluster-8309.11523 BF_2 5.00 0.37 858 189239684 XP_001814498.1 247 1.3e-18 PREDICTED: FMRFamide-related neuropeptides [Tribolium castaneum]>gi|270010961|gb|EFA07409.1| SIFa preprohormone [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q867W1 164 2.2e-10 FMRFamide-related neuropeptides OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11530 BF_2 90.00 4.31 1161 91079764 XP_966717.1 1476 5.3e-161 PREDICTED: cyclin-dependent kinase 7 [Tribolium castaneum]>gi|270004513|gb|EFA00961.1| hypothetical protein TcasGA2_TC003871 [Tribolium castaneum] -- -- -- -- -- K02202 CDK7 cyclin-dependent kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02202 P50613 1138 3.4e-123 Cyclin-dependent kinase 7 OS=Homo sapiens GN=CDK7 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0659 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, kinase subunit CDK7 Cluster-8309.11533 BF_2 23.00 0.91 1350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11539 BF_2 30.60 1.74 1022 332375989 AEE63135.1 946 1.3e-99 unknown [Dendroctonus ponderosae]>gi|478258650|gb|ENN78700.1| hypothetical protein YQE_04872, partial [Dendroctonus ponderosae] -- -- -- -- -- K15106 SLC25A14_30 solute carrier family 25 (mitochondrial carrier), member 14/30 http://www.genome.jp/dbget-bin/www_bget?ko:K15106 O95258 596 2.1e-60 Brain mitochondrial carrier protein 1 OS=Homo sapiens GN=SLC25A14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.11542 BF_2 225.04 3.30 3142 642930503 XP_008196431.1 966 2.0e-101 PREDICTED: uncharacterized protein LOC663881 [Tribolium castaneum]>gi|270010742|gb|EFA07190.1| hypothetical protein TcasGA2_TC010196 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- -- -- Cluster-8309.11555 BF_2 205.85 6.68 1577 332373436 AEE61859.1 1330 6.1e-144 unknown [Dendroctonus ponderosae] 572300323 XM_006616201.1 139 3.79858e-64 PREDICTED: Apis dorsata transmembrane protein 120 homolog (LOC102680574), mRNA -- -- -- -- Q9U1M2 1039 1.4e-111 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.11562 BF_2 76.02 1.44 2493 642922998 XP_008200489.1 888 1.7e-92 PREDICTED: transcription factor GATA-4-like isoform X1 [Tribolium castaneum]>gi|642923000|ref|XP_008200490.1| PREDICTED: transcription factor GATA-4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K09183 GATA4 GATA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09183 P52168 489 1.3e-47 GATA-binding factor A OS=Drosophila melanogaster GN=pnr PE=1 SV=1 PF08273//PF00320//PF01873//PF01412//PF15200 Zinc-binding domain of primase-helicase//GATA zinc finger//Domain found in IF2B/IF5//Putative GTPase activating protein for Arf//Keratinocyte differentiation-associated GO:0006413//GO:0006446//GO:0006351//GO:0006269//GO:0006355 translational initiation//regulation of translational initiation//transcription, DNA-templated//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated GO:0004386//GO:0003700//GO:0043565//GO:0008270//GO:0003896//GO:0005096//GO:0003743 helicase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding//DNA primase activity//GTPase activator activity//translation initiation factor activity GO:0005576//GO:0005667//GO:0005657//GO:0005730//GO:0005840 extracellular region//transcription factor complex//replication fork//nucleolus//ribosome KOG1601 GATA-4/5/6 transcription factors Cluster-8309.11565 BF_2 1.00 5.30 251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11567 BF_2 6.94 0.31 1218 641660258 XP_008181429.1 814 3.2e-84 PREDICTED: uncharacterized protein LOC103308924 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.11569 BF_2 11.30 0.38 1522 328697775 XP_001946487.2 823 3.7e-85 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03849//PF01531//PF04827 Transcription factor Tfb2//Glycosyl transferase family 11//Plant transposon protein GO:0009247//GO:0006289//GO:0005975//GO:0001575 glycolipid biosynthetic process//nucleotide-excision repair//carbohydrate metabolic process//globoside metabolic process GO:0004003//GO:0008107//GO:0016788 ATP-dependent DNA helicase activity//galactoside 2-alpha-L-fucosyltransferase activity//hydrolase activity, acting on ester bonds GO:0016020//GO:0000439//GO:0005657//GO:0005634 membrane//core TFIIH complex//replication fork//nucleus -- -- Cluster-8309.1157 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11570 BF_2 207.53 0.74 12055 546678376 ERL89009.1 14244 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.2699e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 10172 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF03028//PF00004//PF11112//PF09520//PF07728 Dynein heavy chain and region D6 of dynein motor//ATPase family associated with various cellular activities (AAA)//Pyocin activator protein PrtN//Type II restriction endonuclease, TdeIII//AAA domain (dynein-related subfamily) GO:0009307//GO:0007017//GO:0006355//GO:0006308//GO:0007018 DNA restriction-modification system//microtubule-based process//regulation of transcription, DNA-templated//DNA catabolic process//microtubule-based movement GO:0016887//GO:0009036//GO:0003677//GO:0005524//GO:0003777 ATPase activity//Type II site-specific deoxyribonuclease activity//DNA binding//ATP binding//microtubule motor activity GO:0009359//GO:0030286//GO:0005874 Type II site-specific deoxyribonuclease complex//dynein complex//microtubule -- -- Cluster-8309.11574 BF_2 193.00 2.16 4019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11576 BF_2 5.00 0.32 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11577 BF_2 4.00 0.49 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11578 BF_2 170.00 4.77 1778 642926429 XP_008191958.1 412 1.9e-37 PREDICTED: zinc finger protein Xfin-like [Tribolium castaneum]>gi|270008462|gb|EFA04910.1| hypothetical protein TcasGA2_TC014974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF15323 Zinc finger, C2H2 type//Developmental protein GO:0048598 embryonic morphogenesis GO:0046872 metal ion binding GO:0072669 tRNA-splicing ligase complex -- -- Cluster-8309.11579 BF_2 4.74 0.34 862 568257511 ETN65796.1 186 1.5e-11 NADH-ubiquinone oxidoreductase sgdh subunit [Anopheles darlingi] -- -- -- -- -- K03961 NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1160 BF_2 7.00 0.43 970 478259671 ENN79515.1 162 1.0e-08 hypothetical protein YQE_03978, partial [Dendroctonus ponderosae]>gi|546682941|gb|ERL92820.1| hypothetical protein D910_10128 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11604 BF_2 112.96 1.03 4885 642912709 XP_008200970.1 3209 0.0e+00 PREDICTED: PDZ domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NEN9 524 2.3e-51 PDZ domain-containing protein 8 OS=Homo sapiens GN=PDZD8 PE=1 SV=1 PF00595//PF01484//PF13180//PF00130//PF04689 PDZ domain (Also known as DHR or GLGF)//Nematode cuticle collagen N-terminal domain//PDZ domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//DNA binding protein S1FA GO:0035556//GO:0006355 intracellular signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0042302//GO:0003677 protein binding//structural constituent of cuticle//DNA binding GO:0005634 nucleus KOG3532 Predicted protein kinase Cluster-8309.11605 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11606 BF_2 3.00 0.71 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11608 BF_2 41.34 1.13 1811 642919863 XP_008192100.1 1129 1.4e-120 PREDICTED: mitochondrial ribonuclease P protein 3 [Tribolium castaneum] -- -- -- -- -- K17655 MRPP3 mitochondrial ribonuclease P protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17655 Q8JZY4 534 5.8e-53 Mitochondrial ribonuclease P protein 3 OS=Mus musculus GN=Kiaa0391 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11617 BF_2 64.80 1.05 2866 546670638 ERL83322.1 459 1.1e-42 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11621 BF_2 75.00 14.73 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.11645 BF_2 65.58 0.91 3303 768432767 XP_011557722.1 148 1.5e-06 PREDICTED: uncharacterized protein LOC105388496 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11649 BF_2 13.00 0.89 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11650 BF_2 2.00 0.92 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11656 BF_2 65.80 1.54 2076 91078434 XP_974803.1 577 1.7e-56 PREDICTED: uncharacterized protein LOC663674 isoform X1 [Tribolium castaneum]>gi|270003869|gb|EFA00317.1| hypothetical protein TcasGA2_TC003155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445//PF13673//PF13302//PF00583 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.11659 BF_2 11.14 0.40 1467 642913447 XP_008201016.1 1391 4.8e-151 PREDICTED: transmembrane protease serine 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 468 2.1e-45 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.11662 BF_2 104.00 4.53 1247 91087801 XP_967436.1 1166 5.0e-125 PREDICTED: 39S ribosomal protein L39, mitochondrial [Tribolium castaneum]>gi|270010754|gb|EFA07202.1| hypothetical protein TcasGA2_TC010209 [Tribolium castaneum] -- -- -- -- -- K17420 MRPL39 large subunit ribosomal protein L39 http://www.genome.jp/dbget-bin/www_bget?ko:K17420 Q9VUJ0 746 1.0e-77 39S ribosomal protein L39, mitochondrial OS=Drosophila melanogaster GN=mRpL39 PE=1 SV=2 -- -- -- -- GO:0000166 nucleotide binding -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.11666 BF_2 19.00 0.69 1435 676495165 XP_009066800.1 170 1.8e-09 hypothetical protein LOTGIDRAFT_176281 [Lottia gigantea]>gi|556093859|gb|ESO82512.1| hypothetical protein LOTGIDRAFT_176281 [Lottia gigantea] 768311755 CP010983.1 1435 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.11667 BF_2 1.00 0.59 354 -- -- -- -- -- 768311755 CP010983.1 345 2.4185e-179 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11673 BF_2 116.71 9.46 803 546684931 ERL94513.1 553 3.9e-54 hypothetical protein D910_11790 [Dendroctonus ponderosae] -- -- -- -- -- K17429 MRPL48 large subunit ribosomal protein L48 http://www.genome.jp/dbget-bin/www_bget?ko:K17429 Q2YDI5 203 6.2e-15 39S ribosomal protein L48, mitochondrial OS=Bos taurus GN=MRPL48 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4060 Uncharacterized conserved protein Cluster-8309.11676 BF_2 5.00 1.07 482 820997375 XP_004647393.2 673 2.9e-68 PREDICTED: 60S ribosomal protein L27a-like [Octodon degus] 675746405 XM_003818132.2 482 0 PREDICTED: Pan paniscus ribosomal protein L27a (RPL27A), mRNA K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 Q5REY2 677 4.0e-70 60S ribosomal protein L27a OS=Pongo abelii GN=RPL27A PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1742 60s ribosomal protein L15/L27 Cluster-8309.11678 BF_2 1.00 1.32 304 765339464 XP_011493633.1 188 3.1e-12 AAEL017179-PA [Aedes aegypti]>gi|403183234|gb|EJY57947.1| AAEL017179-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- D2WKD9 147 7.3e-09 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11679 BF_2 6.00 0.89 568 642925814 XP_970128.3 469 1.5e-44 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 331 6.3e-30 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF02737//PF01370//PF01073//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase GO:0006550//GO:0006574//GO:0006568//GO:0008207//GO:0006554//GO:0006694//GO:0055114//GO:0008209//GO:0008210//GO:0008152//GO:0006633//GO:0018874//GO:0006631//GO:0006552 isoleucine catabolic process//valine catabolic process//tryptophan metabolic process//C21-steroid hormone metabolic process//lysine catabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//estrogen metabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//fatty acid metabolic process//leucine catabolic process GO:0003854//GO:0050662//GO:0016616//GO:0003857//GO:0003824//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//catalytic activity//oxidoreductase activity -- -- -- -- Cluster-8309.11683 BF_2 3.00 0.49 542 -- -- -- -- -- 697090972 XM_009660015.1 493 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11684 BF_2 27.57 0.51 2544 478256729 ENN76910.1 1562 1.2e-170 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 394 1.4e-36 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF04843//PF09429//PF00083 Major Facilitator Superfamily//Herpesvirus tegument protein, N-terminal conserved region//WW domain binding protein 11//Sugar (and other) transporter GO:0055085//GO:0006508//GO:0006396 transmembrane transport//proteolysis//RNA processing GO:0022857//GO:0008233 transmembrane transporter activity//peptidase activity GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.1169 BF_2 44.00 0.85 2455 158296370 XP_316784.4 167 6.9e-09 AGAP000820-PA [Anopheles gambiae str. PEST]>gi|157015264|gb|EAA43983.4| AGAP000820-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11690 BF_2 24.00 0.43 2645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11696 BF_2 53.00 4.08 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11702 BF_2 8.00 0.36 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11703 BF_2 24.00 0.94 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06399 GTP cyclohydrolase I feedback regulatory protein (GFRP) GO:0009890 negative regulation of biosynthetic process -- -- -- -- -- -- Cluster-8309.11704 BF_2 38.47 0.59 2997 546684809 ERL94391.1 2055 1.0e-227 hypothetical protein D910_11670 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q92832 910 2.4e-96 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 PF00008//PF07645//PF00093 EGF-like domain//Calcium-binding EGF domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.11705 BF_2 20.37 0.36 2643 546684809 ERL94391.1 2063 1.0e-228 hypothetical protein D910_11670 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q90827 873 4.2e-92 Protein NEL OS=Gallus gallus GN=NEL PE=2 SV=1 PF07645//PF00008//PF00093 Calcium-binding EGF domain//EGF-like domain//von Willebrand factor type C domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.11711 BF_2 95.00 3.36 1469 270005374 EFA01822.1 469 3.9e-44 hypothetical protein TcasGA2_TC007424 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11720 BF_2 6.50 0.37 1020 642916792 XP_008199505.1 842 1.5e-87 PREDICTED: deformed epidermal autoregulatory factor 1 [Tribolium castaneum]>gi|270003059|gb|EEZ99506.1| hypothetical protein TcasGA2_TC000085 [Tribolium castaneum] 642916791 XM_008201283.1 117 4.12366e-52 PREDICTED: Tribolium castaneum deformed epidermal autoregulatory factor 1 (LOC655086), mRNA -- -- -- -- Q9Z1T5 286 1.9e-24 Deformed epidermal autoregulatory factor 1 homolog OS=Mus musculus GN=Deaf1 PE=1 SV=1 PF01342 SAND domain -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.11725 BF_2 66.00 18.86 433 642914741 XP_008190333.1 475 2.3e-45 PREDICTED: U6 snRNA-associated Sm-like protein LSm2 [Tribolium castaneum]>gi|270001426|gb|EEZ97873.1| hypothetical protein TcasGA2_TC000255 [Tribolium castaneum] 585667812 XM_002735395.2 111 3.62229e-49 PREDICTED: Saccoglossus kowalevskii U6 snRNA-associated Sm-like protein LSm2-like (LOC100371976), mRNA K12621 LSM2 U6 snRNA-associated Sm-like protein LSm2 http://www.genome.jp/dbget-bin/www_bget?ko:K12621 Q9Y333 448 1.3e-43 U6 snRNA-associated Sm-like protein LSm2 OS=Homo sapiens GN=LSM2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3448 Predicted snRNP core protein Cluster-8309.11726 BF_2 16.78 0.48 1748 642936637 XP_008198518.1 937 2.5e-98 PREDICTED: zinc finger and BTB domain-containing protein 12 [Tribolium castaneum] 642936636 XM_008200296.1 81 7.36744e-32 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q01295 398 3.3e-37 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.11730 BF_2 3.00 0.62 491 156125000 ABU50818.1 278 1.8e-22 Ale o 3 allergen precursor [Aleuroglyphus ovatus] -- -- -- -- -- K09641 TMPRSS11D transmembrane protease, serine 11D http://www.genome.jp/dbget-bin/www_bget?ko:K09641 P35037 242 1.1e-19 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.11733 BF_2 249.73 5.20 2296 478261104 ENN80654.1 893 4.2e-93 hypothetical protein YQE_02926, partial [Dendroctonus ponderosae]>gi|546676414|gb|ERL87432.1| hypothetical protein D910_04826 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T3Y0 203 1.8e-14 Probable E3 ubiquitin-protein ligase sinah OS=Drosophila melanogaster GN=sinah PE=1 SV=2 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.11734 BF_2 20.27 0.40 2429 478261104 ENN80654.1 893 4.5e-93 hypothetical protein YQE_02926, partial [Dendroctonus ponderosae]>gi|546676414|gb|ERL87432.1| hypothetical protein D910_04826 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T3Y0 203 1.9e-14 Probable E3 ubiquitin-protein ligase sinah OS=Drosophila melanogaster GN=sinah PE=1 SV=2 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.11741 BF_2 60.95 0.64 4280 642923317 XP_008193699.1 896 3.5e-93 PREDICTED: PQ-loop repeat-containing protein 1 isoform X1 [Tribolium castaneum] 462316717 APGK01044976.1 64 5.14572e-22 Dendroctonus ponderosae Seq01044986, whole genome shotgun sequence -- -- -- -- Q6NRS2 500 1.2e-48 PQ-loop repeat-containing protein 1 OS=Xenopus laevis GN=pqlc1 PE=2 SV=1 PF00810//PF02383 ER lumen protein retaining receptor//SacI homology domain GO:0006621 protein retention in ER lumen GO:0046923//GO:0042578 ER retention sequence binding//phosphoric ester hydrolase activity GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane -- -- Cluster-8309.11742 BF_2 469.49 7.09 3059 642923319 XP_008193700.1 1100 5.6e-117 PREDICTED: PQ-loop repeat-containing protein 1 isoform X2 [Tribolium castaneum]>gi|270007615|gb|EFA04063.1| hypothetical protein TcasGA2_TC014297 [Tribolium castaneum] 462316717 APGK01044976.1 64 3.66529e-22 Dendroctonus ponderosae Seq01044986, whole genome shotgun sequence -- -- -- -- Q0VCC1 679 1.5e-69 PQ-loop repeat-containing protein 1 OS=Bos taurus GN=PQLC1 PE=2 SV=1 PF03083//PF00810 Sugar efflux transporter for intercellular exchange//ER lumen protein retaining receptor GO:0006621 protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG2913 Predicted membrane protein Cluster-8309.11746 BF_2 190.00 8.93 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11747 BF_2 165.00 6.60 1333 91090270 XP_970541.1 1233 9.2e-133 PREDICTED: uncharacterized protein LOC659116 [Tribolium castaneum]>gi|270013787|gb|EFA10235.1| hypothetical protein TcasGA2_TC012432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11749 BF_2 32.24 0.65 2372 160333791 NP_001103907.1 2126 4.6e-236 eyeless [Tribolium castaneum]>gi|158187657|gb|ABW23132.1| eyeless [Tribolium castaneum] 820837347 XM_012493950.1 167 1.56704e-79 PREDICTED: Apis florea paired box protein Pax-6-like (LOC100870332), mRNA K08031 PAX6 paired box protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08031 P26630 1171 1.0e-126 Paired box protein Pax-6 OS=Danio rerio GN=pax6a PE=2 SV=1 PF05920//PF00292//PF00046 Homeobox KN domain//'Paired box' domain//Homeobox domain GO:0006355//GO:0007275 regulation of transcription, DNA-templated//multicellular organismal development GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0849 Transcription factor PRD and related proteins, contain PAX and HOX domains Cluster-8309.11752 BF_2 11.00 1.64 568 -- -- -- -- -- 642938317 XM_962607.3 43 3.05717e-11 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11769 BF_2 12.68 0.33 1880 642923827 XP_008193896.1 300 2.0e-24 PREDICTED: endonuclease/exonuclease/phosphatase family domain-containing protein 1-like [Tribolium castaneum]>gi|270007767|gb|EFA04215.1| hypothetical protein TcasGA2_TC014464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEQ0 129 5.5e-06 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Danio rerio GN=eepd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11770 BF_2 6.00 1.01 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11790 BF_2 26.00 1.21 1185 61214381 Q8M897.1 739 1.6e-75 RecName: Full=NADH-ubiquinone oxidoreductase chain 1; AltName: Full=NADH dehydrogenase subunit 1>gi|20563031|dbj|BAB92028.1| NADH dehydrogenase subunit 1 (mitochondrion) [Hipposideros terasensis] 550825793 KC252551.1 1185 0 Homo sapiens isolate TDS74 mitochondrion, complete genome K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 Q8M897 739 6.4e-77 NADH-ubiquinone oxidoreductase chain 1 OS=Hipposideros terasensis GN=MT-ND1 PE=3 SV=1 PF00146 NADH dehydrogenase GO:0055114 oxidation-reduction process -- -- GO:0016020 membrane KOG4770 NADH dehydrogenase subunit 1 Cluster-8309.11791 BF_2 119.50 0.46 11259 270002715 EEZ99162.1 7116 0.0e+00 hypothetical protein TcasGA2_TC016161 [Tribolium castaneum] -- -- -- -- -- K06642 PRKDC DNA-dependent protein kinase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06642 Q9DEI1 1179 5.8e-127 DNA-dependent protein kinase catalytic subunit OS=Xenopus laevis GN=prkdc PE=2 SV=1 PF02260//PF00454//PF08163//PF08030 FATC domain//Phosphatidylinositol 3- and 4-kinase//NUC194 domain//Ferric reductase NAD binding domain GO:0016310//GO:0006303//GO:0009069//GO:0055114 phosphorylation//double-strand break repair via nonhomologous end joining//serine family amino acid metabolic process//oxidation-reduction process GO:0005515//GO:0016491//GO:0003677//GO:0004677//GO:0005524//GO:0016773 protein binding//oxidoreductase activity//DNA binding//DNA-dependent protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0891 DNA-dependent protein kinase Cluster-8309.11799 BF_2 132.15 2.39 2604 91081993 XP_969039.1 1700 1.3e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 1.9e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.11804 BF_2 19.00 0.51 1832 642913969 XP_008201495.1 1139 1.0e-121 PREDICTED: tailless isoform X1 [Tribolium castaneum] -- -- -- -- -- K08545 NR2E1, TLX, tll nuclear receptor subfamily 2 group E member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08545 Q9QXZ7 580 2.7e-58 Photoreceptor-specific nuclear receptor OS=Mus musculus GN=Nr2e3 PE=1 SV=1 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3575 FOG: Hormone receptors Cluster-8309.11805 BF_2 252.00 13.50 1068 91080425 XP_968280.1 1012 3.1e-107 PREDICTED: transmembrane protein 147 [Tribolium castaneum]>gi|270005752|gb|EFA02200.1| hypothetical protein TcasGA2_TC007856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFI2 627 5.6e-64 Transmembrane protein 147 OS=Xenopus laevis GN=tmem147 PE=2 SV=1 PF15009 Transmembrane protein 173 GO:0032481//GO:0002218 positive regulation of type I interferon production//activation of innate immune response -- -- -- -- KOG3236 Predicted membrane protein Cluster-8309.11807 BF_2 71.25 2.28 1597 751215591 XP_011160707.1 146 1.2e-06 PREDICTED: DNA ligase 1-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01015//PF06374 Ribosomal S3Ae family//NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006744//GO:0006814//GO:0042254//GO:0015992//GO:0006120//GO:0006412 ubiquinone biosynthetic process//sodium ion transport//ribosome biogenesis//proton transport//mitochondrial electron transport, NADH to ubiquinone//translation GO:0003735//GO:0008137 structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity GO:0005622//GO:0005840//GO:0005743 intracellular//ribosome//mitochondrial inner membrane -- -- Cluster-8309.11810 BF_2 1.00 0.60 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11820 BF_2 30.68 0.57 2528 642930416 XP_008196392.1 471 4.0e-44 PREDICTED: stAR-related lipid transfer protein 3 [Tribolium castaneum]>gi|270011106|gb|EFA07554.1| Start1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DFS4 295 4.2e-25 StAR-related lipid transfer protein 3 OS=Danio rerio GN=stard3 PE=2 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG3845 MLN, STAR and related lipid-binding proteins Cluster-8309.11821 BF_2 34.00 0.56 2822 861463488 XP_004855271.2 306 6.0e-25 PREDICTED: zinc finger protein 397 [Heterocephalus glaber] 736189799 XM_010772771.1 138 2.46762e-63 PREDICTED: Notothenia coriiceps growth factor independent 1 transcription repressor (gfi1), transcript variant X2, mRNA K09223 GFI1 growth factor independent 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09223 Q14591 302 7.2e-26 Zinc finger protein 271 OS=Homo sapiens GN=ZNF271 PE=2 SV=4 PF13912//PF02892//PF01428//PF00096//PF13465//PF01155//PF00130 C2H2-type zinc finger//BED zinc finger//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006464//GO:0035556 cellular protein modification process//intracellular signal transduction GO:0003677//GO:0008270//GO:0046872//GO:0016151 DNA binding//zinc ion binding//metal ion binding//nickel cation binding -- -- -- -- Cluster-8309.11827 BF_2 54.16 0.80 3111 642934662 XP_008197757.1 2210 1.1e-245 PREDICTED: partitioning defective 3 homolog isoform X4 [Tribolium castaneum] 766917723 XM_011496118.1 51 6.28313e-15 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 635 1.9e-64 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.11828 BF_2 31.84 0.41 3551 642926332 XP_968832.2 2936 0.0e+00 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.85992e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 670 1.9e-68 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF04513//PF16685//PF04673//PF13639//PF04728//PF06005//PF00643//PF14634//PF00097 Baculovirus polyhedron envelope protein, PEP, C terminus//zinc RING finger of MSL2//Polyketide synthesis cyclase//Ring finger domain//Lipoprotein leucine-zipper//Protein of unknown function (DUF904)//B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0030639//GO:0000917//GO:0043093 polyketide biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis GO:0061630//GO:0005198//GO:0005515//GO:0046872//GO:0008270 ubiquitin protein ligase activity//structural molecule activity//protein binding//metal ion binding//zinc ion binding GO:0019031//GO:0019028//GO:0019867//GO:0005737//GO:0005622 viral envelope//viral capsid//outer membrane//cytoplasm//intracellular -- -- Cluster-8309.11837 BF_2 7.14 1.46 491 546674201 ERL85641.1 472 5.9e-45 hypothetical protein D910_03058, partial [Dendroctonus ponderosae] -- -- -- -- -- K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 414 1.3e-39 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.11839 BF_2 76.00 2.62 1500 642931703 XP_966917.2 1061 9.1e-113 PREDICTED: GTPase Era, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X2B8 587 3.4e-59 GTPase Era, mitochondrial OS=Salmo salar GN=eral1 PE=2 SV=1 PF00025//PF02421//PF01926//PF00735//PF08477//PF00071//PF04548//PF10662//PF02263//PF00503//PF03193//PF00005 ADP-ribosylation factor family//Ferrous iron transport protein B//50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//Ras family//AIG1 family//Ethanolamine utilisation - propanediol utilisation//Guanylate-binding protein, N-terminal domain//G-protein alpha subunit//Protein of unknown function, DUF258//ABC transporter GO:0007165//GO:0006576//GO:0015684//GO:0007264//GO:0007186 signal transduction//cellular biogenic amine metabolic process//ferrous iron transport//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0015093//GO:0005524//GO:0016887//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//ferrous iron transmembrane transporter activity//ATP binding//ATPase activity//guanyl nucleotide binding//signal transducer activity//GTP binding GO:0016021 integral component of membrane KOG1423 Ras-like GTPase ERA Cluster-8309.11841 BF_2 20.69 0.31 3069 642922398 XP_008193141.1 2127 4.6e-236 PREDICTED: adenylate kinase isoenzyme 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y6K8 307 2.1e-26 Adenylate kinase isoenzyme 5 OS=Homo sapiens GN=AK5 PE=1 SV=2 PF09107//PF00004 Elongation factor SelB, winged helix//ATPase family associated with various cellular activities (AAA) GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0005524//GO:0003723//GO:0005525//GO:0003746 ATP binding//RNA binding//GTP binding//translation elongation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG3079 Uridylate kinase/adenylate kinase Cluster-8309.11842 BF_2 17.16 0.32 2535 642922398 XP_008193141.1 1511 1.0e-164 PREDICTED: adenylate kinase isoenzyme 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q920P5 251 5.3e-20 Adenylate kinase isoenzyme 5 OS=Mus musculus GN=Ak5 PE=2 SV=2 PF09107 Elongation factor SelB, winged helix GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0005525//GO:0003723//GO:0003746 GTP binding//RNA binding//translation elongation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG3079 Uridylate kinase/adenylate kinase Cluster-8309.11844 BF_2 3.87 0.36 739 642924778 XP_008194436.1 448 5.4e-42 PREDICTED: U6 snRNA-associated Sm-like protein LSm4 [Tribolium castaneum] 840425550 LK065217.1 62 1.10644e-21 Apteryx australis mantelli genome assembly AptMant0, scaffold scaffold645 K12623 LSM4 U6 snRNA-associated Sm-like protein LSm4 http://www.genome.jp/dbget-bin/www_bget?ko:K12623 Q9Y4Z0 369 3.2e-34 U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens GN=LSM4 PE=1 SV=1 PF10384 Centromere protein Scm3 -- -- GO:0042393 histone binding GO:0005634 nucleus KOG3293 Small nuclear ribonucleoprotein (snRNP) Cluster-8309.11847 BF_2 204.00 10.75 1081 478249757 ENN70265.1 397 6.5e-36 hypothetical protein YQE_13048, partial [Dendroctonus ponderosae]>gi|546677437|gb|ERL88274.1| hypothetical protein D910_05661 [Dendroctonus ponderosae] 665793661 XM_008546266.1 101 3.43323e-43 PREDICTED: Microplitis demolitor U6 snRNA-associated Sm-like protein LSm6 (LOC103569138), mRNA K12625 LSM6 U6 snRNA-associated Sm-like protein LSm6 http://www.genome.jp/dbget-bin/www_bget?ko:K12625 P62313 344 3.7e-31 U6 snRNA-associated Sm-like protein LSm6 OS=Mus musculus GN=Lsm6 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1783 Small nuclear ribonucleoprotein F Cluster-8309.11848 BF_2 13.51 0.48 1474 642927014 XP_001810799.2 366 3.5e-32 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11851 BF_2 44.33 1.01 2121 642935034 XP_008199914.1 150 5.6e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 8.18336e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF04111//PF03938//PF05835//PF02841//PF10186 Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Synaphin protein//Guanylate-binding protein, C-terminal domain//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0006914//GO:0006836 positive regulation of autophagy//autophagy//neurotransmitter transport GO:0003924//GO:0019905//GO:0051082//GO:0005525 GTPase activity//syntaxin binding//unfolded protein binding//GTP binding -- -- -- -- Cluster-8309.11852 BF_2 19.77 0.41 2321 642935034 XP_008199914.1 150 6.1e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 8.96796e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF03938//PF04111//PF02841//PF05835//PF10186 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Guanylate-binding protein, C-terminal domain//Synaphin protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006836//GO:0010508//GO:0006914 neurotransmitter transport//positive regulation of autophagy//autophagy GO:0005525//GO:0051082//GO:0003924//GO:0019905 GTP binding//unfolded protein binding//GTPase activity//syntaxin binding -- -- -- -- Cluster-8309.1186 BF_2 19.53 1.12 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.11866 BF_2 75.92 2.35 1638 91079414 XP_967324.1 1768 1.0e-194 PREDICTED: iduronate 2-sulfatase [Tribolium castaneum]>gi|270004379|gb|EFA00827.1| hypothetical protein TcasGA2_TC003715 [Tribolium castaneum] -- -- -- -- -- K01136 IDS iduronate 2-sulfatase http://www.genome.jp/dbget-bin/www_bget?ko:K01136 Q08890 1190 4.5e-129 Iduronate 2-sulfatase OS=Mus musculus GN=Ids PE=2 SV=3 PF00884//PF01676//PF01663 Sulfatase//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824//GO:0046872 sulfuric ester hydrolase activity//catalytic activity//metal ion binding -- -- -- -- Cluster-8309.11867 BF_2 11.00 0.92 786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11869 BF_2 17.00 1.34 816 642915563 XP_008190668.1 497 1.2e-47 PREDICTED: uncharacterized protein LOC103312258 [Tribolium castaneum]>gi|270003839|gb|EFA00287.1| hypothetical protein TcasGA2_TC003120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11875 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11878 BF_2 2.00 0.62 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1188 BF_2 13.44 0.84 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.11887 BF_2 20.11 4.08 493 642915266 XP_971845.3 424 2.2e-39 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- K17928 SNX16 sorting nexin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K17928 P57768 200 8.4e-15 Sorting nexin-16 OS=Homo sapiens GN=SNX16 PE=1 SV=2 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.11888 BF_2 46.52 12.15 447 646716106 KDR19493.1 157 1.8e-08 Cytochrome c oxidase subunit 7A-related protein, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P13184 128 1.7e-06 Cytochrome c oxidase subunit 7A2, mitochondrial OS=Bos taurus GN=COX7A2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.11892 BF_2 34.72 0.54 2974 817199200 XP_012275275.1 876 5.1e-91 PREDICTED: 4-hydroxyphenylpyruvate dioxygenase [Orussus abietinus] -- -- -- -- -- K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 P32755 766 1.2e-79 4-hydroxyphenylpyruvate dioxygenase OS=Rattus norvegicus GN=Hpd PE=1 SV=3 PF02050//PF00631 Flagellar FliJ protein//GGL domain GO:0007186//GO:0006935//GO:0007165//GO:0071973 G-protein coupled receptor signaling pathway//chemotaxis//signal transduction//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0004871 motor activity//signal transducer activity GO:0016020//GO:0009288//GO:0005834 membrane//bacterial-type flagellum//heterotrimeric G-protein complex KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.11893 BF_2 19.41 0.96 1131 189239721 XP_967180.2 308 1.4e-25 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 197 4.3e-14 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF01412//PF04921//PF00320 Putative GTPase activating protein for Arf//XAP5, circadian clock regulator//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565//GO:0005096 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding//GTPase activator activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.11897 BF_2 174.00 4.31 1976 642937291 XP_008198773.1 1665 1.1e-182 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X2 [Tribolium castaneum]>gi|270000838|gb|EEZ97285.1| hypothetical protein TcasGA2_TC011089 [Tribolium castaneum] -- -- -- -- -- K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1456 7.8e-160 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.11898 BF_2 65.00 10.42 548 91093274 XP_971370.1 589 1.8e-58 PREDICTED: U6 snRNA-associated Sm-like protein LSm1 [Tribolium castaneum]>gi|270016827|gb|EFA13273.1| hypothetical protein TcasGA2_TC001544 [Tribolium castaneum] -- -- -- -- -- K12620 LSM1 U6 snRNA-associated Sm-like protein LSm1 http://www.genome.jp/dbget-bin/www_bget?ko:K12620 Q5E9Z8 413 1.9e-39 U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus GN=LSM1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1782 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.1190 BF_2 6.80 0.40 995 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.11900 BF_2 37.00 4.51 630 642932317 XP_008197062.1 411 9.0e-38 PREDICTED: uncharacterized protein LOC103314048 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11908 BF_2 20.00 0.62 1638 752866839 XP_011269926.1 154 1.5e-07 PREDICTED: uncharacterized protein LOC105259591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006813//GO:0006814 potassium ion transport//sodium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.11913 BF_2 136.65 2.08 3035 91077232 XP_968256.1 2161 5.2e-240 PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|642913746|ref|XP_008201143.1| PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|270002085|gb|EEZ98532.1| hypothetical protein TcasGA2_TC001036 [Tribolium castaneum] 780675948 XM_011698114.1 402 0 PREDICTED: Wasmannia auropunctata fizzy-related protein homolog (LOC105455066), mRNA K03364 CDH1 cell division cycle 20-like protein 1, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03364 Q9R1K5 1593 1.5e-175 Fizzy-related protein homolog OS=Mus musculus GN=Fzr1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.1192 BF_2 23.00 0.40 2707 641666055 XP_008183596.1 556 5.9e-54 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09229 ZKSCAN KRAB and SCAN domains-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09229 Q9EQB9 517 8.1e-51 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF13465//PF00096//PF13912//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.11921 BF_2 16.00 0.46 1733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.11928 BF_2 81.00 3.04 1400 642921808 XP_008199328.1 1335 1.4e-144 PREDICTED: protein vestigial [Tribolium castaneum] 451810339 AB698923.1 395 0 Tenebrio molitor vg mRNA for vestigial, partial cds -- -- -- -- Q26366 342 8.2e-31 Protein vestigial OS=Drosophila melanogaster GN=vg PE=1 SV=1 PF07545 Vestigial/Tondu family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.11933 BF_2 8.00 0.40 1128 -- -- -- -- -- 462316329 APGK01045114.1 48 1.04067e-13 Dendroctonus ponderosae Seq01045124, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11937 BF_2 11.00 1.32 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11948 BF_2 193.00 6.89 1459 478253978 ENN74270.1 532 1.9e-51 hypothetical protein YQE_09242, partial [Dendroctonus ponderosae]>gi|546674816|gb|ERL86102.1| hypothetical protein D910_03516 [Dendroctonus ponderosae] -- -- -- -- -- K13176 THOC7 THO complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13176 A7RX34 332 1.2e-29 THO complex subunit 7 homolog OS=Nematostella vectensis GN=thoc7 PE=3 SV=1 PF02305//PF08657//PF05531//PF00430//PF10473//PF05615 Capsid protein (F protein)//DASH complex subunit Spc34//Nucleopolyhedrovirus P10 protein//ATP synthase B/B' CF(0)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Tho complex subunit 7 GO:0015992//GO:0008608//GO:0015986//GO:0006397 proton transport//attachment of spindle microtubules to kinetochore//ATP synthesis coupled proton transport//mRNA processing GO:0015078//GO:0005198//GO:0008134//GO:0045502//GO:0042803 hydrogen ion transmembrane transporter activity//structural molecule activity//transcription factor binding//dynein binding//protein homodimerization activity GO:0000445//GO:0005876//GO:0042729//GO:0045263//GO:0019028//GO:0005667//GO:0030286 THO complex part of transcription export complex//spindle microtubule//DASH complex//proton-transporting ATP synthase complex, coupling factor F(o)//viral capsid//transcription factor complex//dynein complex KOG3215 Uncharacterized conserved protein Cluster-8309.11954 BF_2 29.00 1.20 1301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.11955 BF_2 79.05 1.03 3492 642918188 XP_008191403.1 1336 2.7e-144 PREDICTED: adenosine 3'-phospho 5'-phosphosulfate transporter 2 isoform X1 [Tribolium castaneum]>gi|270004524|gb|EFA00972.1| hypothetical protein TcasGA2_TC003883 [Tribolium castaneum] -- -- -- -- -- K15277 SLC35B3, PAPST2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 http://www.genome.jp/dbget-bin/www_bget?ko:K15277 Q29EY2 1018 8.4e-109 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Drosophila pseudoobscura pseudoobscura GN=Papst2 PE=3 SV=2 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1582 UDP-galactose transporter related protein Cluster-8309.11956 BF_2 10.00 0.49 1135 642920682 XP_008192520.1 873 4.3e-91 PREDICTED: transcriptional regulator ATRX homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.11958 BF_2 55.40 1.15 2305 91092928 XP_971830.1 1416 9.6e-154 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 140 1.55477e-64 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 812 4.3e-85 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF07716//PF15898//PF16367//PF00076//PF03938//PF04772//PF01576//PF07851 Basic region leucine zipper//cGMP-dependent protein kinase interacting domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Outer membrane protein (OmpH-like)//Influenza B matrix protein 2 (BM2)//Myosin tail//TMPIT-like protein GO:0015992//GO:0006355 proton transport//regulation of transcription, DNA-templated GO:0003700//GO:0097159//GO:0051082//GO:0043565//GO:0003676//GO:1901363//GO:0003774//GO:0019901 transcription factor activity, sequence-specific DNA binding//organic cyclic compound binding//unfolded protein binding//sequence-specific DNA binding//nucleic acid binding//heterocyclic compound binding//motor activity//protein kinase binding GO:0005667//GO:0016021//GO:0016459 transcription factor complex//integral component of membrane//myosin complex -- -- Cluster-8309.11962 BF_2 200.00 7.19 1451 635124568 XP_008013087.1 144 1.9e-06 PREDICTED: serine protease inhibitor Kazal-type 5 isoform X2 [Chlorocebus sabaeus] -- -- -- -- -- -- -- -- -- Q9NQ38 128 5.6e-06 Serine protease inhibitor Kazal-type 5 OS=Homo sapiens GN=SPINK5 PE=1 SV=2 PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.11966 BF_2 15.26 0.32 2292 768443546 XP_011563593.1 1008 1.9e-106 PREDICTED: uncharacterized protein LOC105393516 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF04218//PF01527//PF05225 DDE superfamily endonuclease//CENP-B N-terminal DNA-binding domain//Transposase//helix-turn-helix, Psq domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0003676//GO:0004803 DNA binding//nucleic acid binding//transposase activity -- -- -- -- Cluster-8309.11968 BF_2 4.00 0.49 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11972 BF_2 2.00 0.77 394 270016479 EFA12925.1 143 6.7e-07 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11981 BF_2 28.00 1.16 1297 189236235 XP_972873.2 777 6.7e-80 PREDICTED: dopamine N-acetyltransferase [Tribolium castaneum]>gi|270005795|gb|EFA02243.1| hypothetical protein TcasGA2_TC007905 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94521 201 1.7e-14 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 PF13508//PF00583//PF01135 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0046500//GO:0042967//GO:0006464//GO:0006479 S-adenosylmethionine metabolic process//acyl-carrier-protein biosynthetic process//cellular protein modification process//protein methylation GO:0008080//GO:0004719 N-acetyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity -- -- -- -- Cluster-8309.11986 BF_2 15.00 0.41 1823 728418448 AIY68369.1 1539 4.1e-168 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q8R0W5 691 3.6e-71 Carboxylesterase 4A OS=Mus musculus GN=Ces4a PE=2 SV=2 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.11989 BF_2 12.72 0.61 1157 861599125 KMQ83546.1 230 1.6e-16 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.11991 BF_2 4.00 0.62 559 546672885 ERL84608.1 381 2.4e-34 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 251 1.2e-20 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.11993 BF_2 241.02 6.73 1786 189240985 XP_001808932.1 2020 6.8e-224 PREDICTED: probable cytosolic Fe-S cluster assembly factor CPIJ010948 [Tribolium castaneum]>gi|270012992|gb|EFA09440.1| hypothetical protein TcasGA2_TC010652 [Tribolium castaneum] 462325677 APGK01041744.1 51 3.57893e-15 Dendroctonus ponderosae Seq01041754, whole genome shotgun sequence -- -- -- -- Q7PWB8 1454 1.2e-159 Probable cytosolic Fe-S cluster assembly factor AGAP009023 OS=Anopheles gambiae GN=AGAP009023 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2439 Nuclear architecture related protein Cluster-8309.11995 BF_2 36.70 0.57 3001 642919403 XP_008191855.1 1043 2.2e-110 PREDICTED: ubiquitin carboxyl-terminal hydrolase 46 [Tribolium castaneum] 642919402 XM_008193633.1 298 2.99097e-152 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 46 (LOC663037), mRNA K11842 USP12_46 ubiquitin carboxyl-terminal hydrolase 12/46 http://www.genome.jp/dbget-bin/www_bget?ko:K11842 P62069 859 2.0e-90 Ubiquitin carboxyl-terminal hydrolase 46 OS=Mus musculus GN=Usp46 PE=1 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.11997 BF_2 75.48 0.97 3533 91083375 XP_966996.1 2096 2.1e-232 PREDICTED: EGF domain-specific O-linked N-acetylglucosamine transferase [Tribolium castaneum]>gi|270006906|gb|EFA03354.1| hypothetical protein TcasGA2_TC013339 [Tribolium castaneum] 242007552 XM_002424559.1 86 2.49824e-34 Pediculus humanus corporis glycosyltransferase, putative, mRNA K18134 EOGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18134 Q9VQB7 1339 5.1e-146 EGF domain-specific O-linked N-acetylglucosamine transferase OS=Drosophila melanogaster GN=Eogt PE=1 SV=1 PF04577//PF06423 Protein of unknown function (DUF563)//GWT1 GO:0006506 GPI anchor biosynthetic process GO:0016746//GO:0016757 transferase activity, transferring acyl groups//transferase activity, transferring glycosyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0411 Uncharacterized membrane protein Cluster-8309.11998 BF_2 41.27 0.53 3532 91083375 XP_966996.1 2096 2.1e-232 PREDICTED: EGF domain-specific O-linked N-acetylglucosamine transferase [Tribolium castaneum]>gi|270006906|gb|EFA03354.1| hypothetical protein TcasGA2_TC013339 [Tribolium castaneum] 242007552 XM_002424559.1 86 2.49752e-34 Pediculus humanus corporis glycosyltransferase, putative, mRNA K18134 EOGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18134 Q9VQB7 1339 5.1e-146 EGF domain-specific O-linked N-acetylglucosamine transferase OS=Drosophila melanogaster GN=Eogt PE=1 SV=1 PF06423//PF04577 GWT1//Protein of unknown function (DUF563) GO:0006506 GPI anchor biosynthetic process GO:0016757//GO:0016746 transferase activity, transferring glycosyl groups//transferase activity, transferring acyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0411 Uncharacterized membrane protein Cluster-8309.12000 BF_2 97.53 1.28 3483 91083375 XP_966996.1 2096 2.0e-232 PREDICTED: EGF domain-specific O-linked N-acetylglucosamine transferase [Tribolium castaneum]>gi|270006906|gb|EFA03354.1| hypothetical protein TcasGA2_TC013339 [Tribolium castaneum] 242007552 XM_002424559.1 86 2.46252e-34 Pediculus humanus corporis glycosyltransferase, putative, mRNA K18134 EOGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18134 Q9VQB7 1339 5.0e-146 EGF domain-specific O-linked N-acetylglucosamine transferase OS=Drosophila melanogaster GN=Eogt PE=1 SV=1 PF06423//PF04577 GWT1//Protein of unknown function (DUF563) GO:0006506 GPI anchor biosynthetic process GO:0016757//GO:0016746 transferase activity, transferring glycosyl groups//transferase activity, transferring acyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0411 Uncharacterized membrane protein Cluster-8309.12003 BF_2 44.53 1.09 1990 642917767 XP_008191359.1 1336 1.6e-144 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 821 3.3e-86 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF02254//PF05199 GMC oxidoreductase//TrkA-N domain//GMC oxidoreductase GO:0006813//GO:0055114 potassium ion transport//oxidation-reduction process GO:0050660//GO:0016614 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.12004 BF_2 5.00 0.35 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12008 BF_2 147.86 1.84 3645 91083749 XP_971342.1 2229 8.1e-248 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1104 9.4e-119 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12011 BF_2 6.93 0.82 639 118792702 XP_320457.3 191 2.9e-12 AGAP012067-PA [Anopheles gambiae str. PEST]>gi|116117024|gb|EAA00314.3| AGAP012067-PA [Anopheles gambiae str. PEST] -- -- -- -- -- K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 Q11002 173 1.5e-11 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF13202//PF13499//PF00036//PF13405//PF09095 EF hand//EF-hand domain pair//EF hand//EF-hand domain//Domain of unknown function (DUF1926) GO:0005975 carbohydrate metabolic process GO:0030246//GO:0005509//GO:0003824 carbohydrate binding//calcium ion binding//catalytic activity -- -- -- -- Cluster-8309.12024 BF_2 3.00 0.54 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12025 BF_2 1.00 1.87 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12038 BF_2 117.00 10.09 772 91077048 XP_968190.1 498 9.0e-48 PREDICTED: coiled-coil domain-containing protein 58 [Tribolium castaneum]>gi|270001743|gb|EEZ98190.1| hypothetical protein TcasGA2_TC000619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FX56 348 9.1e-32 Coiled-coil domain-containing protein 58 OS=Taeniopygia guttata GN=CCDC58 PE=2 SV=1 PF00377 Prion/Doppel alpha-helical domain GO:0051260 protein homooligomerization -- -- GO:0016020 membrane -- -- Cluster-8309.12042 BF_2 22.00 0.40 2586 642924692 XP_008194400.1 1044 1.5e-110 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXD9 210 3.1e-15 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF01534//PF00001//PF00002//PF02086 Frizzled/Smoothened family membrane region//7 transmembrane receptor (rhodopsin family)//7 transmembrane receptor (Secretin family)//D12 class N6 adenine-specific DNA methyltransferase GO:0006306//GO:0007166//GO:0007186//GO:0032775 DNA methylation//cell surface receptor signaling pathway//G-protein coupled receptor signaling pathway//DNA methylation on adenine GO:0009007//GO:0004930 site-specific DNA-methyltransferase (adenine-specific) activity//G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.12043 BF_2 1.00 5.48 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12047 BF_2 183.00 6.48 1468 478260604 ENN80307.1 690 9.3e-70 hypothetical protein YQE_03300, partial [Dendroctonus ponderosae]>gi|546685264|gb|ERL94791.1| hypothetical protein D910_12065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CBW7 500 4.1e-49 Cysteine-rich hydrophobic domain-containing protein 1 OS=Mus musculus GN=Chic1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4101 Cysteine-rich hydrophobic proteins Cluster-8309.12050 BF_2 93.68 0.98 4296 646715135 KDR18839.1 1147 2.8e-122 Zinc finger MYM-type protein 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.12056 BF_2 65.00 0.66 4429 642937210 XP_008198741.1 734 2.2e-74 PREDICTED: uncharacterized protein LOC103314438 [Tribolium castaneum]>gi|270001101|gb|EEZ97548.1| hypothetical protein TcasGA2_TC011398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12057 BF_2 180.00 19.62 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12060 BF_2 63.00 0.93 3135 15450324 AAK96031.1 912 3.6e-95 homeodomain transcription factor Prothoraxless [Tribolium castaneum]>gi|270002803|gb|EEZ99250.1| antennapedia [Tribolium castaneum] 86515363 NM_001039416.1 265 6.91207e-134 Tribolium castaneum prothoraxless (Ptl), mRNA >gnl|BL_ORD_ID|908858 Tribolium castaneum prothoraxless mRNA, complete cds K09307 HOX_7 homeobox protein HoxA/B7 http://www.genome.jp/dbget-bin/www_bget?ko:K09307 P02833 379 9.5e-35 Homeotic protein antennapedia OS=Drosophila melanogaster GN=Antp PE=1 SV=1 PF00046//PF03153 Homeobox domain//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.12070 BF_2 41.96 0.96 2122 332372486 AEE61385.1 1557 3.9e-170 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5LJP9 882 3.0e-93 Asparagine synthetase domain-containing protein CG17486 OS=Drosophila melanogaster GN=CG17486 PE=2 SV=2 PF00733 Asparagine synthase GO:0006531//GO:0006522//GO:0006529 aspartate metabolic process//alanine metabolic process//asparagine biosynthetic process GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0573 Asparagine synthase Cluster-8309.12083 BF_2 6.00 0.36 975 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12091 BF_2 34.98 17.29 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12092 BF_2 67.37 1.29 2477 642934637 XP_008197748.1 1341 5.1e-145 PREDICTED: uncharacterized protein LOC103314202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08072 BDHCT (NUC031) domain GO:0006260 DNA replication GO:0003677//GO:0005524//GO:0016818 DNA binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus -- -- Cluster-8309.12099 BF_2 2.00 0.90 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08491 Squalene epoxidase GO:0055114//GO:0006694//GO:0016114 oxidation-reduction process//steroid biosynthetic process//terpenoid biosynthetic process GO:0004506//GO:0050660 squalene monooxygenase activity//flavin adenine dinucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.121 BF_2 27.06 0.42 2967 270004458 EFA00906.1 1189 2.6e-127 hypothetical protein TcasGA2_TC003812 [Tribolium castaneum] -- -- -- -- -- K10395 KIF4_21_27 kinesin family member 4/21/27 http://www.genome.jp/dbget-bin/www_bget?ko:K10395 P33174 601 1.6e-60 Chromosome-associated kinesin KIF4 OS=Mus musculus GN=Kif4 PE=1 SV=3 PF00633//PF00225 Helix-hairpin-helix motif//Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0003777//GO:0003677//GO:0005524//GO:0008017 microtubule motor activity//DNA binding//ATP binding//microtubule binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0243 Kinesin-like protein Cluster-8309.12103 BF_2 283.78 5.50 2444 826414794 XP_012522095.1 1420 3.5e-154 PREDICTED: calpain-B isoform X5 [Monomorium pharaonis] 805805104 XM_003705388.2 60 4.88913e-20 PREDICTED: Megachile rotundata calpain-A (LOC100882339), transcript variant X9, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 1309 1.1e-142 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF00036//PF13405//PF13833//PF13499//PF13202//PF00648 EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair//EF hand//Calpain family cysteine protease GO:0006508 proteolysis GO:0004198//GO:0005509 calcium-dependent cysteine-type endopeptidase activity//calcium ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.12123 BF_2 3.00 0.72 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12124 BF_2 16.00 1.16 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12128 BF_2 4.00 0.36 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12134 BF_2 12.00 0.47 1361 78214230 ABB36437.1 161 1.9e-08 RE54418p [Drosophila melanogaster] -- -- -- -- -- K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 161 7.8e-10 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1495 Lactate dehydrogenase Cluster-8309.12135 BF_2 4.00 1.08 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01665 Rotavirus non-structural protein NSP3 -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.1214 BF_2 34.00 1.20 1469 642931180 XP_008196472.1 1269 6.8e-137 PREDICTED: pachytene checkpoint protein 2 homolog [Tribolium castaneum]>gi|270012108|gb|EFA08556.1| hypothetical protein TcasGA2_TC006211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P4W8 947 6.1e-101 Pachytene checkpoint protein 2 homolog OS=Xenopus tropicalis GN=trip13 PE=2 SV=1 PF00158//PF07728//PF01695//PF00004//PF02367//PF02562//PF00931//PF06068//PF05496//PF01443//PF00448//PF07724//PF02224//PF00437//PF04851//PF01637//PF07726//PF00005//PF10662//PF00910 Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//NB-ARC domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//SRP54-type protein, GTPase domain//AAA domain (Cdc48 subfamily)//Cytidylate kinase//Type II/IV secretion system protein//Type III restriction enzyme, res subunit//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//ABC transporter//Ethanolamine utilisation - propanediol utilisation//RNA helicase GO:0002949//GO:0006310//GO:0006206//GO:0006576//GO:0006355//GO:0006139//GO:0006810//GO:0006281//GO:0006614 tRNA threonylcarbamoyladenosine modification//DNA recombination//pyrimidine nucleobase metabolic process//cellular biogenic amine metabolic process//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process//transport//DNA repair//SRP-dependent cotranslational protein targeting to membrane GO:0009378//GO:0003724//GO:0005525//GO:0043531//GO:0003678//GO:0003723//GO:0003677//GO:0000166//GO:0004127//GO:0016887//GO:0008134//GO:0005524//GO:0016787 four-way junction helicase activity//RNA helicase activity//GTP binding//ADP binding//DNA helicase activity//RNA binding//DNA binding//nucleotide binding//cytidylate kinase activity//ATPase activity//transcription factor binding//ATP binding//hydrolase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0744 AAA+-type ATPase Cluster-8309.12140 BF_2 3.00 0.35 646 270015669 EFA12117.1 748 7.7e-77 hypothetical protein TcasGA2_TC002263 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.12141 BF_2 117.62 3.32 1771 546684870 ERL94452.1 439 1.4e-40 hypothetical protein D910_11729 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045//PF09398 LisH//FOP N terminal dimerisation domain GO:0034453 microtubule anchoring GO:0005515 protein binding GO:0005815 microtubule organizing center -- -- Cluster-8309.12143 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12147 BF_2 2.09 1.09 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12149 BF_2 27.39 1.69 965 478257001 ENN77165.1 586 7.0e-58 hypothetical protein YQE_06304, partial [Dendroctonus ponderosae]>gi|546675571|gb|ERL86740.1| hypothetical protein D910_04146 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3UJZ3 330 1.4e-29 Armadillo repeat-containing protein 7 OS=Mus musculus GN=Armc7 PE=2 SV=2 PF00514//PF01245//PF01157 Armadillo/beta-catenin-like repeat//Ribosomal protein L19//Ribosomal protein L21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG4646 Uncharacterized conserved protein, contains ARM repeats Cluster-8309.1216 BF_2 12.33 0.37 1679 -- -- -- -- -- 642934192 XM_008201425.1 79 9.1465e-31 PREDICTED: Tribolium castaneum uncharacterized LOC657839 (LOC657839), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12162 BF_2 26.00 0.33 3582 478254748 ENN74985.1 1310 2.9e-141 hypothetical protein YQE_08442, partial [Dendroctonus ponderosae] 198455838 XM_001360087.2 43 2.02883e-10 Drosophila pseudoobscura pseudoobscura GA17177 (Dpse\GA17177), partial mRNA K04577 CALCRL calcitonin receptor-like http://www.genome.jp/dbget-bin/www_bget?ko:K04577 Q8AXU4 529 4.4e-52 Calcitonin gene-related peptide type 1 receptor OS=Oncorhynchus gorbuscha GN=calcrl PE=2 SV=1 PF00002//PF02793//PF09384 7 transmembrane receptor (Secretin family)//Hormone receptor domain//UTP15 C terminal GO:0007186//GO:0006364 G-protein coupled receptor signaling pathway//rRNA processing GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020//GO:0005730 integral component of membrane//membrane//nucleolus -- -- Cluster-8309.12169 BF_2 9.00 1.00 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12174 BF_2 4.00 0.37 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12175 BF_2 12.00 0.70 1000 751239865 XP_011173940.1 228 2.4e-16 PREDICTED: putative uncharacterized protein FLJ37770 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- Q3ZCU0 144 5.4e-08 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12180 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04162//PF05373 Gyrovirus capsid protein (VP1)//L-proline 3-hydroxylase, C-terminal GO:0055114 oxidation-reduction process GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0019028 viral capsid -- -- Cluster-8309.12184 BF_2 13.00 0.64 1142 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12187 BF_2 131.00 1.61 3694 546681742 ERL91774.1 4465 0.0e+00 hypothetical protein D910_09100 [Dendroctonus ponderosae] 815770796 XM_012380129.1 60 7.42168e-20 PREDICTED: Linepithema humile uncharacterized LOC105679844 (LOC105679844), transcript variant X3, mRNA -- -- -- -- Q5ACV9 167 4.3e-10 Cell surface superoxide dismutase [Cu-Zn] 6 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=SOD6 PE=1 SV=1 PF01194//PF00080 RNA polymerases N / 8 kDa subunit//Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006206//GO:0006801//GO:0006144//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//superoxide metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.12191 BF_2 19.20 1.19 960 642921367 XP_008192837.1 423 5.5e-39 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K12375 ARSI_J arylsulfatase I/J http://www.genome.jp/dbget-bin/www_bget?ko:K12375 Q5FYB1 219 1.0e-16 Arylsulfatase I OS=Homo sapiens GN=ARSI PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.12192 BF_2 21.00 0.53 1943 189233571 XP_967872.2 611 1.8e-60 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D668 225 4.2e-17 Arrestin domain-containing protein 2 OS=Mus musculus GN=Arrdc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12193 BF_2 10.00 1.35 597 170063379 XP_001867078.1 283 5.9e-23 serine 3-dehydrogenase [Culex quinquefasciatus]>gi|167881022|gb|EDS44405.1| serine 3-dehydrogenase [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- D2WKD9 256 3.3e-21 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00608//PF15836//PF00106 Adenoviral fibre protein (repeat/shaft region)//SSTK-interacting protein, TSSK6-activating co-chaperone protein//short chain dehydrogenase GO:0007155//GO:0019062//GO:0009405//GO:0008152 cell adhesion//virion attachment to host cell//pathogenesis//metabolic process GO:0051087//GO:0016491 chaperone binding//oxidoreductase activity -- -- -- -- Cluster-8309.12195 BF_2 144.41 6.17 1267 546677394 ERL88240.1 298 2.3e-24 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- K19363 LITAF lipopolysaccharide-induced tumor necrosis factor-alpha factor http://www.genome.jp/dbget-bin/www_bget?ko:K19363 Q8QGW7 153 6.1e-09 Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog OS=Gallus gallus GN=LITAF PE=2 SV=1 PF03811 InsA N-terminal domain GO:0006313 transposition, DNA-mediated -- -- -- -- -- -- Cluster-8309.12197 BF_2 3.00 0.62 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12208 BF_2 12.00 0.37 1635 594064207 XP_006056122.1 1626 3.0e-178 PREDICTED: L-lactate dehydrogenase A chain isoform X1 [Bubalus bubalis] 92446377 BC072009.1 1635 0 Homo sapiens lactate dehydrogenase A, mRNA (cDNA clone IMAGE:4551914), **** WARNING: chimeric clone **** K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 P19858 1553 3.6e-171 L-lactate dehydrogenase A chain OS=Bos taurus GN=LDHA PE=2 SV=2 PF02056//PF11975//PF00056//PF07992//PF02866 Family 4 glycosyl hydrolase//Family 4 glycosyl hydrolase C-terminal domain//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114//GO:0005975 oxidation-reduction process//carbohydrate metabolic process GO:0016616//GO:0016491//GO:0004553 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1495 Lactate dehydrogenase Cluster-8309.12212 BF_2 20.24 1.29 943 642918102 XP_008194021.1 600 1.6e-59 PREDICTED: Krueppel-like factor 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q13887 198 2.8e-14 Krueppel-like factor 5 OS=Homo sapiens GN=KLF5 PE=1 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.12213 BF_2 214.00 3.51 2841 546685087 ERL94614.1 1458 1.6e-158 hypothetical protein D910_11891 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- F1MT22 317 1.3e-27 Leucine-rich repeat-containing G-protein coupled receptor 5 OS=Bos taurus GN=LGR5 PE=3 SV=2 PF04999//PF00560//PF02932//PF06682//PF06783//PF13855 Cell division protein FtsL//Leucine Rich Repeat//Neurotransmitter-gated ion-channel transmembrane region//SOCE-associated regulatory factor of calcium homoeostasis//Uncharacterised protein family (UPF0239)//Leucine rich repeat GO:0051301//GO:0006811//GO:0007049//GO:2001256 cell division//ion transport//cell cycle//regulation of store-operated calcium entry GO:0005515 protein binding GO:0016020//GO:0030176//GO:0016021 membrane//integral component of endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.12216 BF_2 15.00 0.42 1794 728417130 AIY68334.1 1386 2.2e-150 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 586 5.4e-59 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.12218 BF_2 77.46 1.11 3201 642929350 XP_008195799.1 2124 1.1e-235 PREDICTED: translation initiation factor IF-2, mitochondrial [Tribolium castaneum] 769830568 XM_011632673.1 65 1.06696e-22 PREDICTED: Pogonomyrmex barbatus translation initiation factor IF-2, mitochondrial (LOC105423025), transcript variant X4, mRNA K02519 infB, MTIF2 translation initiation factor IF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K02519 P46198 1350 2.5e-147 Translation initiation factor IF-2, mitochondrial OS=Bos taurus GN=MTIF2 PE=1 SV=1 PF01926//PF03144//PF03193//PF08477//PF02421//PF00025//PF10662 50S ribosome-binding GTPase//Elongation factor Tu domain 2//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation GO:0015684//GO:0007264//GO:0006576 ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process GO:0005525//GO:0003924//GO:0015093//GO:0005524 GTP binding//GTPase activity//ferrous iron transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase) Cluster-8309.12219 BF_2 32.92 0.67 2345 642929350 XP_008195799.1 1388 1.7e-150 PREDICTED: translation initiation factor IF-2, mitochondrial [Tribolium castaneum] 769830568 XM_011632673.1 65 7.78972e-23 PREDICTED: Pogonomyrmex barbatus translation initiation factor IF-2, mitochondrial (LOC105423025), transcript variant X4, mRNA K02519 infB, MTIF2 translation initiation factor IF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K02519 P46198 839 3.2e-88 Translation initiation factor IF-2, mitochondrial OS=Bos taurus GN=MTIF2 PE=1 SV=1 PF10662//PF02421//PF00025//PF01926//PF03193//PF08477 Ethanolamine utilisation - propanediol utilisation//Ferrous iron transport protein B//ADP-ribosylation factor family//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0006576//GO:0015684//GO:0007264 cellular biogenic amine metabolic process//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0015093//GO:0005524//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding GO:0016021 integral component of membrane KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase) Cluster-8309.12223 BF_2 37.18 0.66 2631 478259695 ENN79539.1 904 2.6e-94 hypothetical protein YQE_04002, partial [Dendroctonus ponderosae]>gi|546679825|gb|ERL90217.1| hypothetical protein D910_07570 [Dendroctonus ponderosae] -- -- -- -- -- K05995 pepE dipeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K05995 Q91642 697 1.1e-71 Alpha-aspartyl dipeptidase OS=Xenopus laevis GN=aad-a PE=1 SV=1 PF03575 Peptidase family S51 GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- -- -- Cluster-8309.12238 BF_2 3.00 0.57 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12242 BF_2 26.00 1.10 1272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00538//PF03074 linker histone H1 and H5 family//Glutamate-cysteine ligase GO:0006750//GO:0006749//GO:0006334 glutathione biosynthetic process//glutathione metabolic process//nucleosome assembly GO:0004357//GO:0003677 glutamate-cysteine ligase activity//DNA binding GO:0017109//GO:0000786//GO:0005634 glutamate-cysteine ligase complex//nucleosome//nucleus -- -- Cluster-8309.12253 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12256 BF_2 9.00 0.35 1367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12268 BF_2 79.90 1.23 3006 642927554 XP_008195313.1 3133 0.0e+00 PREDICTED: UPF0505 protein C16orf62 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z3J2 2101 1.9e-234 UPF0505 protein C16orf62 OS=Homo sapiens GN=C16orf62 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3682 Predicted membrane protein (associated with esophageal cancer in humans) Cluster-8309.12269 BF_2 58.00 0.85 3150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12270 BF_2 43.00 1.63 1394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12272 BF_2 25.00 0.49 2442 546686651 ERL95783.1 2003 8.7e-222 hypothetical protein D910_00297, partial [Dendroctonus ponderosae]>gi|546687005|gb|ERL95945.1| hypothetical protein D910_00649, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P18173 1023 1.6e-109 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF07992//PF05834//PF00732//PF02558//PF02254//PF05199 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Ketopantoate reductase PanE/ApbA//TrkA-N domain//GMC oxidoreductase GO:0006813//GO:0015940//GO:0055114//GO:0016117 potassium ion transport//pantothenate biosynthetic process//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0016705//GO:0016614//GO:0050660//GO:0008677 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity -- -- -- -- Cluster-8309.12280 BF_2 10.51 0.37 1461 91078614 XP_967493.1 1057 2.6e-112 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 37 1.76662e-07 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 O43752 526 4.0e-52 Syntaxin-6 OS=Homo sapiens GN=STX6 PE=1 SV=1 PF05739//PF00957//PF00523//PF05478 SNARE domain//Synaptobrevin//Fusion glycoprotein F0//Prominin GO:0006948//GO:0016192 induction by virus of host cell-cell fusion//vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.12283 BF_2 8.88 1.22 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12294 BF_2 2.00 0.36 522 642924544 XP_008194337.1 340 1.3e-29 PREDICTED: endocuticle structural glycoprotein SgAbd-2-like [Tribolium castaneum]>gi|270006763|gb|EFA03211.1| hypothetical protein TcasGA2_TC013131 [Tribolium castaneum] 759049336 XM_011335417.1 40 1.29984e-09 PREDICTED: Cerapachys biroi endocuticle structural glycoprotein SgAbd-2-like (LOC105277210), mRNA -- -- -- -- Q7M4F4 278 8.1e-24 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12296 BF_2 92.00 3.23 1477 91081129 XP_975539.1 621 9.4e-62 PREDICTED: GILT-like protein F37H8.5 [Tribolium castaneum]>gi|270005287|gb|EFA01735.1| hypothetical protein TcasGA2_TC007331 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O17861 219 1.6e-16 GILT-like protein F37H8.5 OS=Caenorhabditis elegans GN=F37H8.5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.12298 BF_2 24.51 1.40 1020 512885690 XP_002943975.2 150 2.7e-07 PREDICTED: ephrin type-A receptor 8, partial [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- P54753 142 9.3e-08 Ephrin type-B receptor 3 OS=Homo sapiens GN=EPHB3 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.12304 BF_2 21.99 0.36 2873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12309 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12316 BF_2 6.00 6.63 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12317 BF_2 12.51 0.32 1914 861587829 KMQ82562.1 454 2.8e-42 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] 795022879 XM_012005361.1 136 2.15355e-62 PREDICTED: Vollenhovia emeryi uncharacterized LOC105557942 (LOC105557942), transcript variant X1, mRNA -- -- -- -- Q7JQ07 160 1.4e-09 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF13404//PF13545//PF04545//PF01047 AsnC-type helix-turn-helix domain//Crp-like helix-turn-helix domain//Sigma-70, region 4//MarR family GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0016987//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//sigma factor activity//DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.12335 BF_2 174.55 5.69 1571 478257435 ENN77591.1 577 1.3e-56 hypothetical protein YQE_05886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q75UQ2 317 7.3e-28 Craniofacial development protein 1 OS=Rattus norvegicus GN=Cfdp1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4776 Uncharacterized conserved protein BCNT Cluster-8309.12336 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12337 BF_2 43.42 1.16 1857 270011728 EFA08176.1 443 5.2e-41 hypothetical protein TcasGA2_TC005803 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26627 182 3.9e-12 Sperm receptor for egg jelly OS=Strongylocentrotus purpuratus GN=REJ PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12341 BF_2 39.34 0.54 3310 270011730 EFA08178.1 830 1.2e-85 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 281 2.3e-23 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF01477 PLAT/LH2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12345 BF_2 10.00 0.32 1611 334883358 BAK38643.1 453 3.1e-42 unnamed protein product [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.12348 BF_2 22.23 0.50 2164 642913328 XP_008195273.1 253 6.5e-19 PREDICTED: protein roadkill isoform X4 [Tribolium castaneum] -- -- -- -- -- K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 215 6.8e-16 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.1235 BF_2 17.00 0.32 2507 749156135 XP_011129696.1 973 2.4e-102 phospholipase D [Gregarina niphandrodes]>gi|608680243|gb|EZG73001.1| phospholipase D [Gregarina niphandrodes] 302821821 XM_002992526.1 36 1.10146e-06 Selaginella moellendorffii hypothetical protein, mRNA -- -- -- -- Q38882 1315 2.2e-143 Phospholipase D alpha 1 OS=Arabidopsis thaliana GN=PLDALPHA1 PE=1 SV=2 PF00614//PF01287 Phospholipase D Active site motif//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006452//GO:0006448//GO:0045905//GO:0045901 translational frameshifting//regulation of translational elongation//positive regulation of translational termination//positive regulation of translational elongation GO:0043022//GO:0003723//GO:0003824//GO:0003746 ribosome binding//RNA binding//catalytic activity//translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.12351 BF_2 1.00 0.77 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12354 BF_2 76.52 1.61 2271 380013584 XP_003690832.1 860 2.8e-89 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Apis florea] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 Q8AXB3 505 1.7e-49 Vascular endothelial growth factor receptor kdr-like OS=Danio rerio GN=kdrl PE=1 SV=1 PF13895//PF00069//PF05790//PF07714 Immunoglobulin domain//Protein kinase domain//Immunoglobulin C2-set domain//Protein tyrosine kinase GO:0007155//GO:0006468 cell adhesion//protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding GO:0016021 integral component of membrane KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.12360 BF_2 87.76 1.10 3639 642932799 XP_008196988.1 3710 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X2 [Tribolium castaneum]>gi|270012453|gb|EFA08901.1| hypothetical protein TcasGA2_TC006604 [Tribolium castaneum] 642932798 XM_008198766.1 89 5.53237e-36 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1806 3.7e-200 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF00637//PF13639//PF17122//PF00097//PF17123//PF14634 Region in Clathrin and VPS//Ring finger domain//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//zinc-RING finger domain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005622 intracellular KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.12362 BF_2 15.85 1.02 935 478254273 ENN74527.1 148 4.2e-07 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04108//PF10174//PF08074//PF03153//PF10473//PF02970 Autophagy protein Apg17//RIM-binding protein of the cytomatrix active zone//CHDCT2 (NUC038) domain//Transcription factor IIA, alpha/beta subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Tubulin binding cofactor A GO:0006367//GO:0006914//GO:0007021//GO:0006355 transcription initiation from RNA polymerase II promoter//autophagy//tubulin complex assembly//regulation of transcription, DNA-templated GO:0003677//GO:0015631//GO:0042803//GO:0005524//GO:0045502//GO:0008134//GO:0008270//GO:0051082//GO:0016818 DNA binding//tubulin binding//protein homodimerization activity//ATP binding//dynein binding//transcription factor binding//zinc ion binding//unfolded protein binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634//GO:0030286//GO:0005667//GO:0005672//GO:0045298//GO:0048786 nucleus//dynein complex//transcription factor complex//transcription factor TFIIA complex//tubulin complex//presynaptic active zone -- -- Cluster-8309.12365 BF_2 167.00 2.38 3225 91081765 XP_973226.1 2303 1.9e-256 PREDICTED: leucine-rich repeat-containing protein 4 [Tribolium castaneum]>gi|270006351|gb|EFA02799.1| kekkon-1 [Tribolium castaneum] 642921386 XM_968133.2 47 1.09037e-12 PREDICTED: Tribolium castaneum kekkon-1 (LOC662007), mRNA -- -- -- -- Q3UQ28 320 6.7e-28 Peroxidasin homolog OS=Mus musculus GN=Pxdn PE=2 SV=2 PF13895//PF13855//PF00560 Immunoglobulin domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12369 BF_2 6.00 0.47 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12371 BF_2 115.08 2.36 2329 642927688 XP_008196543.1 1060 1.8e-112 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 1.1e-27 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF00128//PF13855 Alpha amylase, catalytic domain//Leucine rich repeat GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824//GO:0005515 cation binding//catalytic activity//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.12373 BF_2 15.00 0.59 1347 166947671 ABZ04122.1 460 4.0e-43 putative cuticle protein CP5 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F3 325 7.4e-29 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF05529//PF00379 B-cell receptor-associated protein 31-like//Insect cuticle protein GO:0006886 intracellular protein transport GO:0042302 structural constituent of cuticle GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.12375 BF_2 24.00 0.65 1830 642920608 XP_008192486.1 1051 1.6e-111 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 567 8.8e-57 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.12378 BF_2 25.00 1.64 926 478254273 ENN74527.1 147 5.4e-07 hypothetical protein YQE_08851, partial [Dendroctonus ponderosae]>gi|546671467|gb|ERL83769.1| hypothetical protein D910_00997 [Dendroctonus ponderosae]>gi|546672146|gb|ERL84147.1| hypothetical protein D910_01508 [Dendroctonus ponderosae]>gi|546674915|gb|ERL86197.1| hypothetical protein D910_03608 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10174//PF02970//PF04815//PF04048 RIM-binding protein of the cytomatrix active zone//Tubulin binding cofactor A//Sec23/Sec24 helical domain//Sec8 exocyst complex component specific domain GO:0007021//GO:0015031//GO:0006886//GO:0006888//GO:0006904 tubulin complex assembly//protein transport//intracellular protein transport//ER to Golgi vesicle-mediated transport//vesicle docking involved in exocytosis GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0000145//GO:0048786//GO:0030127//GO:0045298 exocyst//presynaptic active zone//COPII vesicle coat//tubulin complex -- -- Cluster-8309.12381 BF_2 233.00 10.54 1212 74961114 O97398.1 573 2.8e-56 RecName: Full=Chymotrypsin; Flags: Precursor [Phaedon cochleariae]>gi|4210802|emb|CAA76928.1| chymotrypsin [Phaedon cochleariae] -- -- -- -- -- K01310 CTRB chymotrypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01310 O97398 573 1.2e-57 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.12388 BF_2 37.00 1.58 1268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12390 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10394 Histone acetyl transferase HAT1 N-terminus GO:0042967//GO:0016568 acyl-carrier-protein biosynthetic process//chromatin modification GO:0004402 histone acetyltransferase activity GO:0000123 histone acetyltransferase complex -- -- Cluster-8309.12393 BF_2 27.00 0.95 1474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12395 BF_2 45.00 0.97 2226 642929412 XP_008195828.1 2495 7.1e-279 PREDICTED: uncharacterized protein LOC663405 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12396 BF_2 27.09 0.47 2684 642929410 XP_008195826.1 895 2.9e-93 PREDICTED: uncharacterized protein LOC663405 isoform X1 [Tribolium castaneum]>gi|270009626|gb|EFA06074.1| hypothetical protein TcasGA2_TC008910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JXX2 194 2.3e-13 cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila grimshawi GN=Pde6 PE=3 SV=1 PF00015//PF05313 Methyl-accepting chemotaxis protein (MCP) signalling domain//Poxvirus P21 membrane protein GO:0007165 signal transduction GO:0004871 signal transducer activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.12397 BF_2 22.91 0.61 1868 642929414 XP_008195829.1 800 2.1e-82 PREDICTED: uncharacterized protein LOC663405 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.12402 BF_2 16.11 2.57 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.12405 BF_2 63.00 2.61 1295 478256669 ENN76851.1 163 1.1e-08 hypothetical protein YQE_06692, partial [Dendroctonus ponderosae]>gi|546676036|gb|ERL87121.1| hypothetical protein D910_04521 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006560//GO:0006525//GO:0006090//GO:0071436//GO:0006814 proline metabolic process//arginine metabolic process//pyruvate metabolic process//sodium ion export//sodium ion transport GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.12407 BF_2 8.00 0.52 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12416 BF_2 58.99 0.61 4308 642913527 XP_008201051.1 2518 2.9e-281 PREDICTED: protein timeless homolog [Tribolium castaneum]>gi|270002773|gb|EEZ99220.1| timeout [Tribolium castaneum] -- -- -- -- -- K03155 TIMELESS timeless http://www.genome.jp/dbget-bin/www_bget?ko:K03155 Q9UNS1 1419 3.3e-155 Protein timeless homolog OS=Homo sapiens GN=TIMELESS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1974 DNA topoisomerase I-interacting protein Cluster-8309.12420 BF_2 74.04 1.08 3165 322779294 EFZ09583.1 890 1.3e-92 hypothetical protein SINV_11475, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09280 XPC-binding domain GO:0006289//GO:0006281//GO:0043161 nucleotide-excision repair//DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process GO:0003684 damaged DNA binding -- -- -- -- Cluster-8309.12425 BF_2 127.00 4.95 1361 332374168 AEE62225.1 386 1.5e-34 unknown [Dendroctonus ponderosae]>gi|478258063|gb|ENN78201.1| hypothetical protein YQE_05353, partial [Dendroctonus ponderosae]>gi|546682562|gb|ERL92485.1| hypothetical protein D910_09798 [Dendroctonus ponderosae]>gi|828177629|gb|AKK25138.1| odorant binding protein 13 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P54193 144 7.3e-08 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.12426 BF_2 126.83 3.99 1617 291170322 ADD82417.1 213 2.1e-14 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27017 135 9.6e-07 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.12430 BF_2 20.00 0.43 2211 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12431 BF_2 37.77 1.64 1248 642919326 XP_008191826.1 1123 4.9e-120 PREDICTED: alkylated DNA repair protein alkB homolog 1 [Tribolium castaneum] -- -- -- -- -- K10765 ALKBH1 alkylated DNA repair protein alkB homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10765 P0CB42 524 5.8e-52 Alkylated DNA repair protein alkB homolog 1 OS=Mus musculus GN=Alkbh1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2731 DNA alkylation damage repair protein Cluster-8309.12436 BF_2 43.20 0.98 2130 282392019 NP_001164153.1 156 1.1e-07 fibroblast growth factor 8 precursor [Tribolium castaneum]>gi|270002739|gb|EEZ99186.1| fibroblast growth factor 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13411 MerR HTH family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.12439 BF_2 16.00 1.19 851 91088485 XP_975796.1 199 4.6e-13 PREDICTED: uncharacterized protein LOC658401 [Tribolium castaneum]>gi|270011723|gb|EFA08171.1| hypothetical protein TcasGA2_TC005795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12441 BF_2 93.93 1.15 3703 642922794 XP_008193328.1 1466 2.4e-159 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 801 1.3e-83 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.12443 BF_2 4.00 0.59 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12446 BF_2 17.35 0.83 1160 91087671 XP_976426.1 355 5.2e-31 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12449 BF_2 2.00 0.31 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12451 BF_2 8.00 0.34 1277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04189 Gcd10p family GO:0030488 tRNA methylation -- -- GO:0031515 tRNA (m1A) methyltransferase complex -- -- Cluster-8309.12453 BF_2 21.95 0.49 2163 91080493 XP_970962.1 1391 7.1e-151 PREDICTED: bestrophin-3 [Tribolium castaneum]>gi|270005768|gb|EFA02216.1| hypothetical protein TcasGA2_TC007875 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8BGM5 883 2.4e-93 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.12455 BF_2 1.00 3.42 265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12456 BF_2 10.89 1.13 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.1246 BF_2 2.00 0.69 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12468 BF_2 2.00 1.27 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12472 BF_2 40.47 0.73 2622 270003223 EEZ99670.1 1702 7.5e-187 hypothetical protein TcasGA2_TC002427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12474 BF_2 114.87 2.22 2448 642918045 XP_008198993.1 760 1.2e-77 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q8VII6 339 3.2e-30 Choline transporter-like protein 1 OS=Rattus norvegicus GN=Slc44a1 PE=1 SV=1 PF05454 Dystroglycan (Dystrophin-associated glycoprotein 1) GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016010 dystrophin-associated glycoprotein complex KOG1362 Choline transporter-like protein Cluster-8309.12484 BF_2 6.00 0.34 1035 270017238 EFA13684.1 388 6.9e-35 hypothetical protein TcasGA2_TC016048 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 257 4.4e-21 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12488 BF_2 1.00 3.05 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10716 NADH dehydrogenase transmembrane subunit GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor -- -- -- -- Cluster-8309.12491 BF_2 32.09 0.45 3238 642911478 XP_008199441.1 3004 0.0e+00 PREDICTED: protein dispatched isoform X3 [Tribolium castaneum] 642911477 XM_008201219.1 185 2.11623e-89 PREDICTED: Tribolium castaneum protein dispatched (LOC662282), transcript variant X3, mRNA -- -- -- -- Q9VNJ5 1639 7.7e-181 Protein dispatched OS=Drosophila melanogaster GN=disp PE=1 SV=1 PF00873//PF03176//PF02460 AcrB/AcrD/AcrF family//MMPL family//Patched family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane KOG3664 Predicted patched transmembrane receptor Cluster-8309.12493 BF_2 5.00 10.80 282 290909033 ADD70031.1 141 8.1e-07 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00715//PF01395 Interleukin 2//PBP/GOBP family GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0005134//GO:0008083//GO:0005549 interleukin-2 receptor binding//growth factor activity//odorant binding GO:0005576//GO:0005893 extracellular region//interleukin-2 receptor complex -- -- Cluster-8309.12494 BF_2 1.00 13.37 226 290909033 ADD70031.1 188 2.3e-12 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395//PF14630 PBP/GOBP family//Origin recognition complex (ORC) subunit 5 C-terminus GO:0006260 DNA replication GO:0005549 odorant binding GO:0000808//GO:0005634 origin recognition complex//nucleus -- -- Cluster-8309.12495 BF_2 33.00 1.78 1061 19526442 AAL89717.1 1279 3.4e-138 cathepsin B [Apriona germari] 19526441 AF483623.1 390 0 Apriona germari cathepsin B mRNA, complete cds K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P00787 719 1.2e-74 Cathepsin B OS=Rattus norvegicus GN=Ctsb PE=1 SV=2 PF08127//PF03051//PF00112 Peptidase family C1 propeptide//Peptidase C1-like family//Papain family cysteine protease GO:0050790//GO:0006508 regulation of catalytic activity//proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.12499 BF_2 5.00 0.35 888 329762922 AEC04842.1 411 1.3e-37 chemosensory protein [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q9W1C9 334 4.4e-30 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1250 BF_2 1.00 0.74 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12501 BF_2 1.68 0.36 484 546675622 ERL86775.1 170 6.1e-10 hypothetical protein D910_04181, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12502 BF_2 248.56 1.90 5756 642913216 XP_008201442.1 1142 1.4e-121 PREDICTED: uncharacterized protein LOC664132 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF08136//PF05190 Sulfatase//30S ribosomal protein subunit S22 family//MutS family domain IV GO:0006412//GO:0008152//GO:0006298//GO:0042254 translation//metabolic process//mismatch repair//ribosome biogenesis GO:0005524//GO:0030983//GO:0008484//GO:0003735 ATP binding//mismatched DNA binding//sulfuric ester hydrolase activity//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.1251 BF_2 17.00 0.78 1197 149675211 ABR27687.1 1423 7.7e-155 cuticle proprotein proCP5.2 [Callinectes sapidus] 149675210 EF639839.1 811 0 Callinectes sapidus cuticle proprotein proCP5.2 mRNA, complete cds -- -- -- -- P81580 364 2.0e-33 Cuticle protein CP1158 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12510 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12515 BF_2 117.21 1.86 2926 642924825 XP_967668.2 841 5.7e-87 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 496 2.4e-48 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12516 BF_2 127.01 2.02 2917 642924825 XP_967668.2 841 5.7e-87 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 496 2.4e-48 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12521 BF_2 2.00 0.32 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12524 BF_2 95.43 1.32 3305 642916496 XP_008191066.1 1558 4.7e-170 PREDICTED: elongation factor Tu GTP-binding domain-containing protein 1 [Tribolium castaneum]>gi|270003614|gb|EFA00062.1| hypothetical protein TcasGA2_TC002875 [Tribolium castaneum] -- -- -- -- -- K14536 RIA1 ribosome assembly protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14536 Q7Z2Z2 739 1.8e-76 Elongation factor Tu GTP-binding domain-containing protein 1 OS=Homo sapiens GN=EFTUD1 PE=1 SV=2 PF00071//PF03764//PF00503//PF08477//PF02961//PF03144 Ras family//Elongation factor G, domain IV//G-protein alpha subunit//Ras of Complex, Roc, domain of DAPkinase//Barrier to autointegration factor//Elongation factor Tu domain 2 GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0003677//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//DNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0467 Translation elongation factor 2/ribosome biogenesis protein RIA1 and related proteins Cluster-8309.12525 BF_2 4.00 1.06 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1253 BF_2 30.00 0.69 2099 91091770 XP_966678.1 1578 1.4e-172 PREDICTED: S-adenosylmethionine synthase isoform X1 [Tribolium castaneum] 731227747 XM_010629558.1 202 4.83882e-99 PREDICTED: Fukomys damarensis methionine adenosyltransferase I, alpha (Mat1a), transcript variant X1, mRNA K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 P40320 1519 4.1e-167 S-adenosylmethionine synthase OS=Drosophila melanogaster GN=Sam-S PE=2 SV=2 PF02772//PF02773//PF00438 S-adenosylmethionine synthetase, central domain//S-adenosylmethionine synthetase, C-terminal domain//S-adenosylmethionine synthetase, N-terminal domain GO:0006556//GO:0006555 S-adenosylmethionine biosynthetic process//methionine metabolic process GO:0004478 methionine adenosyltransferase activity -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8309.12531 BF_2 8.00 0.72 752 -- -- -- -- -- 462283408 APGK01056946.1 48 6.82997e-14 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12532 BF_2 24.00 0.40 2773 270012124 EFA08572.1 1362 2.1e-147 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 438 1.2e-41 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 PF00366 Ribosomal protein S17 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.12544 BF_2 122.00 7.17 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.12546 BF_2 24.00 0.53 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.12547 BF_2 14.10 0.38 1839 270015076 EFA11524.1 469 4.9e-44 hypothetical protein TcasGA2_TC014239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01186//PF09726 Lysyl oxidase//Transmembrane protein GO:0055114 oxidation-reduction process GO:0016641//GO:0005507 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//copper ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.12550 BF_2 29.86 4.19 585 728418383 AIY68367.1 340 1.4e-29 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12556 BF_2 130.00 0.88 6485 642928525 XP_008193828.1 723 6.1e-73 PREDICTED: mucin-4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12558 BF_2 13.00 1.10 781 478253541 ENN73859.1 190 4.7e-12 hypothetical protein YQE_09551, partial [Dendroctonus ponderosae]>gi|546685413|gb|ERL94926.1| hypothetical protein D910_12198 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12559 BF_2 2.00 0.40 494 805812681 XP_012147725.1 275 4.1e-22 PREDICTED: uncharacterized protein LOC105663445, partial [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12561 BF_2 141.93 1.08 5809 478251276 ENN71747.1 2015 8.4e-223 hypothetical protein YQE_11567, partial [Dendroctonus ponderosae] 159484014 XM_001700004.1 35 9.24876e-06 Chlamydomonas reinhardtii strain CC-503 cw92 mt+ K18164 NDUFAF7 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18164 Q5XI79 955 2.8e-101 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 OS=Rattus norvegicus GN=Ndufaf7 PE=2 SV=1 PF10192//PF06814 Rhodopsin-like GPCR transmembrane domain//Lung seven transmembrane receptor GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone -- -- GO:0016021 integral component of membrane KOG2901 Uncharacterized conserved protein Cluster-8309.12564 BF_2 7.00 0.54 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12565 BF_2 2.07 1.25 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12578 BF_2 103.00 1.54 3088 156564353 NP_001096055.1 2137 3.2e-237 aspartate 1-decarboxylase [Tribolium castaneum]>gi|155675826|gb|ABU25221.1| aspartate 1-decarboxylase [Tribolium castaneum] -- -- -- -- -- K01594 CSAD sulfinoalanine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01594 Q9Y600 1387 1.2e-151 Cysteine sulfinic acid decarboxylase OS=Homo sapiens GN=CSAD PE=1 SV=2 PF01276//PF01212//PF00282 Orn/Lys/Arg decarboxylase, major domain//Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain GO:0006531//GO:0019752//GO:0006523//GO:0019482//GO:0006520 aspartate metabolic process//carboxylic acid metabolic process//alanine biosynthetic process//beta-alanine metabolic process//cellular amino acid metabolic process GO:0003824//GO:0016831//GO:0030170//GO:0004068//GO:0016829 catalytic activity//carboxy-lyase activity//pyridoxal phosphate binding//aspartate 1-decarboxylase activity//lyase activity -- -- KOG0629 Glutamate decarboxylase and related proteins Cluster-8309.12584 BF_2 7.00 0.49 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12586 BF_2 28.00 1.45 1094 325930039 ADZ45521.1 624 3.1e-62 GREBP [Homo sapiens] 893712365 KT250597.1 1094 0 Homo sapiens haplogroup H5a1 mitochondrion, complete genome K03879 ND2 NADH-ubiquinone oxidoreductase chain 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03879 P03891 492 2.6e-48 NADH-ubiquinone oxidoreductase chain 2 OS=Homo sapiens GN=MT-ND2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12587 BF_2 5.00 0.41 797 270010544 EFA06992.1 185 1.8e-11 hypothetical protein TcasGA2_TC009954 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1259 BF_2 34.00 0.91 1843 642936139 XP_008198314.1 1006 2.7e-106 PREDICTED: T-cell leukemia homeobox protein 2 [Tribolium castaneum]>gi|270014244|gb|EFA10692.1| hypothetical protein TcasGA2_TC011749 [Tribolium castaneum] 583976831 XM_006783706.1 36 8.056e-07 PREDICTED: Neolamprologus brichardi homeobox protein HMX2-like (LOC102779030), mRNA K15607 TLX3, HOX11L2 T-cell leukemia homeobox protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15607 O93367 470 1.6e-45 T-cell leukemia homeobox protein 3 OS=Gallus gallus GN=TLX3 PE=2 SV=1 PF00046//PF01346//PF05920 Homeobox domain//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Homeobox KN domain GO:0006355//GO:0006457 regulation of transcription, DNA-templated//protein folding GO:0003677 DNA binding -- -- -- -- Cluster-8309.12590 BF_2 22.11 0.94 1270 91084009 XP_976477.1 450 5.4e-42 PREDICTED: uncharacterized protein LOC664207 [Tribolium castaneum]>gi|270007998|gb|EFA04446.1| hypothetical protein TcasGA2_TC014748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12591 BF_2 17.00 0.89 1082 270012003 EFA08451.1 220 2.2e-15 hypothetical protein TcasGA2_TC006098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.12594 BF_2 70.81 5.12 866 642931265 XP_008196504.1 671 8.8e-68 PREDICTED: high mobility group B protein 13-like [Tribolium castaneum]>gi|270012132|gb|EFA08580.1| hypothetical protein TcasGA2_TC006235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03435 144 4.6e-08 Non-histone protein 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NHP10 PE=1 SV=1 PF00527 E7 protein, Early protein GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG0381 HMG box-containing protein Cluster-8309.12597 BF_2 5.00 0.56 663 270003368 EEZ99815.1 364 2.7e-32 hypothetical protein TcasGA2_TC002595 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T635 326 2.8e-29 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.1260 BF_2 1.00 0.34 408 597743327 XP_007233743.1 182 2.1e-11 PREDICTED: dnaJ homolog subfamily C member 2 [Astyanax mexicanus] -- -- -- -- -- K09522 DNAJC2 DnaJ homolog subfamily C member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09522 Q6P2Y3 176 4.3e-12 DnaJ homolog subfamily C member 2 OS=Xenopus tropicalis GN=dnajc2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12601 BF_2 4.00 0.37 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12603 BF_2 17.08 0.49 1737 478256535 ENN76719.1 295 7.0e-24 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P18714 276 4.6e-23 Gastrula zinc finger protein xFG20-1 OS=Xenopus laevis PE=3 SV=2 PF13465//PF02891//PF02892//PF04810//PF13912//PF01363//PF07562//PF01428//PF16622//PF02176//PF00096//PF05495//PF00130//PF00628//PF06467 Zinc-finger double domain//MIZ/SP-RING zinc finger//BED zinc finger//Sec23/Sec24 zinc finger//C2H2-type zinc finger//FYVE zinc finger//Nine Cysteines Domain of family 3 GPCR//AN1-like Zinc finger//zinc-finger C2H2-type//TRAF-type zinc finger//Zinc finger, C2H2 type//CHY zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//MYM-type Zinc finger with FCS sequence motif GO:0035556//GO:0007186//GO:0006886//GO:0006888 intracellular signal transduction//G-protein coupled receptor signaling pathway//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0005515//GO:0004930//GO:0003677 metal ion binding//zinc ion binding//protein binding//G-protein coupled receptor activity//DNA binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.12605 BF_2 215.43 6.09 1766 642937110 XP_008198695.1 605 8.0e-60 PREDICTED: major facilitator superfamily domain-containing protein 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBP5 230 1.0e-17 Major facilitator superfamily domain-containing protein 9 OS=Homo sapiens GN=MFSD9 PE=2 SV=2 PF07690//PF00083//PF01306 Major Facilitator Superfamily//Sugar (and other) transporter//LacY proton/sugar symporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.12610 BF_2 69.37 0.43 6967 642924185 XP_008194188.1 5828 0.0e+00 PREDICTED: chitin synthase 1 isoform X1 [Tribolium castaneum]>gi|33867317|gb|AAQ55059.1| chitin synthase CHS1A [Tribolium castaneum]>gi|34148367|gb|AAQ62693.1| chitin synthase variant 1 [Tribolium castaneum] 627401361 KF147149.1 1128 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 4.0e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 PF04689 DNA binding protein S1FA GO:0006355//GO:0006031 regulation of transcription, DNA-templated//chitin biosynthetic process GO:0004100//GO:0003677 chitin synthase activity//DNA binding GO:0005634 nucleus KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.12618 BF_2 13.00 0.55 1275 795173580 XP_011843102.1 1193 3.8e-128 PREDICTED: nucleophosmin isoform X1 [Mandrillus leucophaeus] 262331543 NM_002520.6 1257 0 Homo sapiens nucleophosmin (nucleolar phosphoprotein B23, numatrin) (NPM1), transcript variant 1, mRNA K11276 NPM1 nucleophosmin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11276 P06748 1170 7.3e-127 Nucleophosmin OS=Homo sapiens GN=NPM1 PE=1 SV=2 PF02724//PF06524//PF05793//PF04147//PF04931//PF01365//PF16276 CDC45-like protein//NOA36 protein//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Nop14-like family//DNA polymerase phi//RIH domain//Nucleophosmin C-terminal domain GO:0006351//GO:0032968//GO:0006367//GO:0006816//GO:0070588//GO:0006270//GO:0006260 transcription, DNA-templated//positive regulation of transcription elongation from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//calcium ion transport//calcium ion transmembrane transport//DNA replication initiation//DNA replication GO:0005262//GO:0003677//GO:0003887//GO:0003676//GO:0008270 calcium channel activity//DNA binding//DNA-directed DNA polymerase activity//nucleic acid binding//zinc ion binding GO:0005634//GO:0016020//GO:0042575//GO:0032040 nucleus//membrane//DNA polymerase complex//small-subunit processome -- -- Cluster-8309.12626 BF_2 39.65 0.59 3106 270017042 EFA13488.1 1756 4.8e-193 hypothetical protein TcasGA2_TC004227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21329 392 2.9e-36 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila funebris GN=jockey\pol PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12635 BF_2 1.00 0.41 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12637 BF_2 36.84 1.35 1429 642912981 XP_008201337.1 924 6.7e-97 PREDICTED: calexcitin-1 isoform X1 [Tribolium castaneum] 157127291 XM_001654858.1 71 2.17166e-26 Aedes aegypti AAEL010792-RA partial mRNA -- -- -- -- Q10131 275 4.9e-23 Calexcitin-1 OS=Caenorhabditis elegans GN=cex-1 PE=3 SV=1 PF12763//PF09830//PF13499//PF13833//PF10591//PF13405//PF13202//PF00036 Cytoskeletal-regulatory complex EF hand//ATP adenylyltransferase//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF hand GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005515//GO:0005509//GO:0003877 protein binding//calcium ion binding//ATP adenylyltransferase activity GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.12639 BF_2 6.63 1.80 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12641 BF_2 200.00 70.93 404 157129316 XP_001655365.1 155 2.8e-08 AAEL002467-PA [Aedes aegypti]>gi|108882100|gb|EAT46325.1| AAEL002467-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095//PF01607 WAP-type (Whey Acidic Protein) 'four-disulfide core'//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061//GO:0030414 chitin binding//peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.12642 BF_2 1.93 0.58 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04120 Low affinity iron permease GO:0055085 transmembrane transport -- -- -- -- -- -- Cluster-8309.12643 BF_2 13.38 0.60 1216 91094905 XP_973449.1 1188 1.4e-127 PREDICTED: F-box/SPRY domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270006590|gb|EFA03038.1| hypothetical protein TcasGA2_TC010464 [Tribolium castaneum] 242007554 XM_002424560.1 186 2.17085e-90 Pediculus humanus corporis F-box/SPRY-domain protein, putative, mRNA K10319 FBXO45 F-box protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K10319 B4HQ29 1043 3.7e-112 F-box/SPRY domain-containing protein 1 OS=Drosophila sechellia GN=Fsn PE=3 SV=1 PF00646//PF00622//PF12937 F-box domain//SPRY domain//F-box-like -- -- GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.12647 BF_2 1.00 3.42 265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03823 Neurokinin B GO:0007217 tachykinin receptor signaling pathway -- -- -- -- -- -- Cluster-8309.12648 BF_2 13.68 1.25 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537 Scorpion toxin-like domain GO:0006810 transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.1265 BF_2 41.96 0.91 2219 91092776 XP_973805.1 1617 4.5e-177 PREDICTED: uncharacterized protein C4orf29 isoform X2 [Tribolium castaneum]>gi|270014895|gb|EFA11343.1| hypothetical protein TcasGA2_TC010883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C1A9 1064 2.5e-114 Uncharacterized protein C4orf29 homolog OS=Mus musculus PE=2 SV=1 PF02129 X-Pro dipeptidyl-peptidase (S15 family) -- -- GO:0016787 hydrolase activity -- -- KOG1551 Uncharacterized conserved protein Cluster-8309.12651 BF_2 7.12 0.64 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12652 BF_2 4.00 0.63 553 21617523 AAM66718.1 550 6.0e-54 larval cuticle protein 12.3 [Apriona germari] 21617522 AF518323.1 236 1.53051e-118 Apriona germari larval cuticle protein 12.3 (LCP12.3) mRNA, complete cds -- -- -- -- O02387 237 4.9e-19 Larval cuticle protein LCP-17 OS=Bombyx mori GN=LCP17 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.12653 BF_2 27.20 0.80 1716 642931509 XP_968544.2 778 6.8e-80 PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|642931511|ref|XP_008196616.1| PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DC8 631 3.1e-64 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens GN=ECHDC3 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.12654 BF_2 12.57 0.33 1859 642931509 XP_968544.2 791 2.3e-81 PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|642931511|ref|XP_008196616.1| PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DC8 628 7.5e-64 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens GN=ECHDC3 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.12657 BF_2 20.48 0.96 1183 646706249 KDR13577.1 495 3.1e-47 cAMP-specific 3',5'-cyclic phosphodiesterase, partial [Zootermopsis nevadensis] 642935593 XM_008199853.1 101 3.76324e-43 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X15, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 Q8IRU4 289 9.7e-25 cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F OS=Drosophila melanogaster GN=dnc PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.12660 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12662 BF_2 4.00 0.80 496 546674048 ERL85536.1 142 1.1e-06 hypothetical protein D910_02955, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1267 BF_2 25.00 0.60 2029 795011741 XP_011874268.1 720 4.3e-73 PREDICTED: uncharacterized protein LOC105565573 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- O86236 130 4.6e-06 Uncharacterized transposase-like protein HI_1328.1 OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) GN=HI_1328.1 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12672 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12677 BF_2 15.49 0.38 2004 642933166 XP_008197284.1 1818 2.0e-200 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 731 9.2e-76 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- -- -- Cluster-8309.12680 BF_2 3.00 0.68 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12683 BF_2 1.00 0.34 411 270013377 EFA09825.1 328 2.5e-28 hypothetical protein TcasGA2_TC011972 [Tribolium castaneum] -- -- -- -- -- K08635 MMEL1 membrane metallo-endopeptidase-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08635 O44857 241 1.2e-19 Neprilysin-2 OS=Caenorhabditis elegans GN=nep-2 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.12689 BF_2 17.33 0.56 1576 478266693 ENN82870.1 1026 1.1e-108 hypothetical protein YQE_00763, partial [Dendroctonus ponderosae]>gi|546684080|gb|ERL93799.1| hypothetical protein D910_11085 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TS68 575 8.9e-58 Putative methyltransferase NSUN6 OS=Mus musculus GN=Nsun6 PE=2 SV=2 PF01189//PF01472//PF01728 16S rRNA methyltransferase RsmF//PUA domain//FtsJ-like methyltransferase GO:0032259 methylation GO:0008168//GO:0003723 methyltransferase activity//RNA binding -- -- KOG1122 tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) Cluster-8309.1269 BF_2 43.78 2.14 1141 91088231 XP_973706.1 993 5.3e-105 PREDICTED: factor VIII intron 22 protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00558 214 4.7e-16 Factor VIII intron 22 protein OS=Mus musculus GN=F8a1 PE=2 SV=1 PF08656 DASH complex subunit Dad3 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.12695 BF_2 11.00 2.49 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12701 BF_2 26.95 1.43 1073 332376963 AEE63621.1 643 1.9e-64 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13220 WBP4, FBP21 WW domain-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13220 Q5HZF2 177 8.6e-12 WW domain-binding protein 4 OS=Rattus norvegicus GN=Wbp4 PE=2 SV=1 PF00397//PF06220 WW domain//U1 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0150 Spliceosomal protein FBP21 Cluster-8309.12704 BF_2 28.07 0.44 2944 91076346 XP_966525.1 1658 1.1e-181 PREDICTED: leucine zipper putative tumor suppressor 2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4W1 429 1.4e-40 Leucine zipper putative tumor suppressor 2 homolog OS=Xenopus laevis GN=lzts2 PE=2 SV=1 PF10288//PF01008//PF00769 Cytoplasmic tRNA 2-thiolation protein 2//Initiation factor 2 subunit family//Ezrin/radixin/moesin family GO:0044237//GO:0002098//GO:0034227 cellular metabolic process//tRNA wobble uridine modification//tRNA thio-modification GO:0000049//GO:0008092 tRNA binding//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane -- -- Cluster-8309.12707 BF_2 148.00 6.81 1196 332374592 AEE62437.1 715 9.6e-73 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 391 1.5e-36 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.12709 BF_2 76.94 2.16 1776 91077290 XP_974504.1 296 5.5e-24 PREDICTED: synaptonemal complex protein 1 [Tribolium castaneum]>gi|270002764|gb|EEZ99211.1| IKK gamma [Tribolium castaneum] -- -- -- -- -- -- -- -- -- C5DJH6 163 6.0e-10 Spindle pole body component 110 OS=Lachancea thermotolerans (strain ATCC 56472 / CBS 6340 / NRRL Y-8284) GN=SPC110 PE=3 SV=1 PF13912//PF00038//PF00096 C2H2-type zinc finger//Intermediate filament protein//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005198 metal ion binding//structural molecule activity GO:0005882 intermediate filament -- -- Cluster-8309.12718 BF_2 10.00 0.36 1449 828177654 AKK25149.1 338 6.0e-29 chemosensory protein 6 [Dendroctonus ponderosae] 462357473 APGK01030461.1 73 1.70288e-27 Dendroctonus ponderosae Seq01030471, whole genome shotgun sequence -- -- -- -- Q9W1C9 126 9.5e-06 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12720 BF_2 23.00 8.16 404 158187796 ABW23187.1 373 1.5e-33 ribosomal protein rpl34 [Arenicola marina] 262401270 FJ774817.1 267 6.40288e-136 Scylla paramamosain putative 60S ribosomal protein RPL34 mRNA, partial cds K02915 RP-L34e, RPL34 large subunit ribosomal protein L34e http://www.genome.jp/dbget-bin/www_bget?ko:K02915 P45842 321 6.4e-29 60S ribosomal protein L34 OS=Aedes albopictus GN=RpL34 PE=2 SV=2 PF01199 Ribosomal protein L34e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1790 60s ribosomal protein L34 Cluster-8309.12721 BF_2 5.00 0.47 729 568250947 ETN60559.1 336 5.2e-29 mitochondrial ATP synthase coupling factor 6 [Anopheles darlingi] -- -- -- -- -- K02131 ATPeF0F6, ATP5J F-type H+-transporting ATPase subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02131 Q24407 259 1.8e-21 ATP synthase-coupling factor 6, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-Cf6 PE=3 SV=1 PF05511 Mitochondrial ATP synthase coupling factor 6 GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.12730 BF_2 11.72 0.34 1720 642920521 XP_008192385.1 1130 1.0e-120 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96BD5 200 3.0e-14 PHD finger protein 21A OS=Homo sapiens GN=PHF21A PE=1 SV=1 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12738 BF_2 3.00 4.48 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12747 BF_2 177.37 4.99 1774 91094671 XP_972558.1 2090 5.1e-232 PREDICTED: USP6 N-terminal-like protein isoform X1 [Tribolium castaneum] 827555134 XM_012693612.1 128 5.58088e-58 PREDICTED: Bombyx mori USP6 N-terminal-like protein (LOC101746723), mRNA -- -- -- -- Q80XC3 1096 3.9e-118 USP6 N-terminal-like protein OS=Mus musculus GN=Usp6nl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.1275 BF_2 153.00 7.04 1196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12753 BF_2 5.00 0.33 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12754 BF_2 37.82 2.04 1061 189242304 XP_001808377.1 648 5.0e-65 PREDICTED: uncharacterized protein LOC100141613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1276 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12764 BF_2 14.39 0.78 1056 570341948 AHE77372.1 494 3.6e-47 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 285 2.5e-24 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.12767 BF_2 229.99 1.58 6364 642913900 XP_008201205.1 5742 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 Q9H1A4 2718 1.2e-305 Anaphase-promoting complex subunit 1 OS=Homo sapiens GN=ANAPC1 PE=1 SV=1 PF12859//PF07475 Anaphase-promoting complex subunit 1//HPr Serine kinase C-terminal domain GO:0016310//GO:0006109//GO:0000160 phosphorylation//regulation of carbohydrate metabolic process//phosphorelay signal transduction system GO:0004672//GO:0000155//GO:0005524 protein kinase activity//phosphorelay sensor kinase activity//ATP binding GO:0009365//GO:0005680 protein histidine kinase complex//anaphase-promoting complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.12771 BF_2 68.36 1.04 3026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12774 BF_2 12.00 0.51 1263 642937652 XP_966876.3 626 2.1e-62 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01611 354 3.0e-32 Zinc finger Y-chromosomal protein 1 OS=Xenopus laevis GN=zfy1 PE=2 SV=1 PF08273//PF00096//PF13465//PF00462//PF02150 Zinc-binding domain of primase-helicase//Zinc finger, C2H2 type//Zinc-finger double domain//Glutaredoxin//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006206//GO:0045454//GO:0006269//GO:0006118 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//cell redox homeostasis//DNA replication, synthesis of RNA primer//obsolete electron transport GO:0003677//GO:0004386//GO:0015035//GO:0009055//GO:0046872//GO:0003896//GO:0003899//GO:0008270 DNA binding//helicase activity//protein disulfide oxidoreductase activity//electron carrier activity//metal ion binding//DNA primase activity//DNA-directed RNA polymerase activity//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.12776 BF_2 22.96 0.74 1578 478260276 ENN80028.1 233 9.8e-17 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q95LI3 152 1.0e-08 Zinc finger Y-chromosomal protein OS=Bos taurus GN=ZFY PE=2 SV=1 PF02150//PF13465//PF00096//PF09599//PF07776 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//Salmonella-Shigella invasin protein C (IpaC_SipC)//Zinc-finger associated domain (zf-AD) GO:0009405//GO:0006351//GO:0006144//GO:0006206 pathogenesis//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus KOG1721 FOG: Zn-finger Cluster-8309.12783 BF_2 146.67 4.03 1809 91079028 XP_974924.1 1752 8.2e-193 PREDICTED: glutamate-rich WD repeat-containing protein 1 [Tribolium castaneum]>gi|270004178|gb|EFA00626.1| hypothetical protein TcasGA2_TC003502 [Tribolium castaneum] 687865299 LK927543.1 35 2.84297e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K14848 RRB1, GRWD1 ribosome assembly protein RRB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14848 Q9BQ67 1160 1.5e-125 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 PF00400//PF08676 WD domain, G-beta repeat//MutL C terminal dimerisation domain GO:0006298 mismatch repair GO:0005524//GO:0005515 ATP binding//protein binding GO:0005634 nucleus KOG0302 Ribosome Assembly protein Cluster-8309.12787 BF_2 137.60 2.11 3018 642924466 XP_001813222.2 1512 9.3e-165 PREDICTED: peroxisome biogenesis protein 1 [Tribolium castaneum]>gi|270007904|gb|EFA04352.1| hypothetical protein TcasGA2_TC014648 [Tribolium castaneum] 195378559 XM_002048015.1 51 6.0931e-15 Drosophila virilis GJ13751 (Dvir\GJ13751), mRNA K13338 PEX1 peroxin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13338 O43933 883 3.3e-93 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 PF07724//PF00004//PF05496//PF06068//PF01695//PF07728//PF02562//PF09262 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//PhoH-like protein//Peroxisome biogenesis factor 1, N-terminal GO:0006310//GO:0006281//GO:0007031 DNA recombination//DNA repair//peroxisome organization GO:0009378//GO:0016887//GO:0003678//GO:0005524 four-way junction helicase activity//ATPase activity//DNA helicase activity//ATP binding GO:0005777//GO:0009379//GO:0005657 peroxisome//Holliday junction helicase complex//replication fork KOG0735 AAA+-type ATPase Cluster-8309.12789 BF_2 27.53 0.41 3084 642924466 XP_001813222.2 1747 5.3e-192 PREDICTED: peroxisome biogenesis protein 1 [Tribolium castaneum]>gi|270007904|gb|EFA04352.1| hypothetical protein TcasGA2_TC014648 [Tribolium castaneum] 195378559 XM_002048015.1 51 6.22796e-15 Drosophila virilis GJ13751 (Dvir\GJ13751), mRNA K13338 PEX1 peroxin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13338 O43933 883 3.4e-93 Peroxisome biogenesis factor 1 OS=Homo sapiens GN=PEX1 PE=1 SV=1 PF07724//PF00437//PF05496//PF01443//PF06068//PF00910//PF00493//PF00005//PF03193//PF03266//PF07726//PF00004//PF00158//PF01926//PF01695//PF07728//PF00931//PF01580//PF02562//PF02367//PF06414//PF09262 AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//TIP49 C-terminus//RNA helicase//MCM2/3/5 family//ABC transporter//Protein of unknown function, DUF258//NTPase//ATPase family associated with various cellular activities (AAA)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//50S ribosome-binding GTPase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//NB-ARC domain//FtsK/SpoIIIE family//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Peroxisome biogenesis factor 1, N-terminal GO:0007031//GO:0002949//GO:0006310//GO:0006810//GO:0006281//GO:0006355//GO:0006260 peroxisome organization//tRNA threonylcarbamoyladenosine modification//DNA recombination//transport//DNA repair//regulation of transcription, DNA-templated//DNA replication GO:0003678//GO:0003723//GO:0003677//GO:0043531//GO:0005525//GO:0009378//GO:0003724//GO:0005524//GO:0098519//GO:0008134//GO:0003924//GO:0000166//GO:0016301//GO:0016887 DNA helicase activity//RNA binding//DNA binding//ADP binding//GTP binding//four-way junction helicase activity//RNA helicase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//GTPase activity//nucleotide binding//kinase activity//ATPase activity GO:0005657//GO:0005777//GO:0005667//GO:0009379 replication fork//peroxisome//transcription factor complex//Holliday junction helicase complex KOG0735 AAA+-type ATPase Cluster-8309.12796 BF_2 7.00 0.76 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12797 BF_2 3.00 0.35 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12798 BF_2 1.00 1.29 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12813 BF_2 3.00 0.33 665 642916919 XP_008199554.1 616 1.6e-61 PREDICTED: F-box/LRR-repeat protein 16 [Tribolium castaneum] -- -- -- -- -- K10282 FBXL16 F-box and leucine-rich repeat protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K10282 Q8N461 200 1.1e-14 F-box/LRR-repeat protein 16 OS=Homo sapiens GN=FBXL16 PE=2 SV=2 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.12818 BF_2 3.00 0.34 658 607360775 EZA55096.1 396 5.1e-36 hypothetical protein X777_05351, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12821 BF_2 227.38 3.51 2995 546677878 ERL88630.1 1340 8.1e-145 hypothetical protein D910_06015, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH20 295 5.0e-25 TATA box-binding protein-associated factor RNA polymerase I subunit B OS=Drosophila melanogaster GN=CG6241 PE=2 SV=1 PF08273//PF00833 Zinc-binding domain of primase-helicase//Ribosomal S17 GO:0006351//GO:0006412//GO:0006269//GO:0042254 transcription, DNA-templated//translation//DNA replication, synthesis of RNA primer//ribosome biogenesis GO:0004386//GO:0003896//GO:0008270//GO:0003735 helicase activity//DNA primase activity//zinc ion binding//structural constituent of ribosome GO:0005657//GO:0005840//GO:0005622//GO:0005730 replication fork//ribosome//intracellular//nucleolus -- -- Cluster-8309.12824 BF_2 36.16 0.47 3527 159798024 ABX00684.1 1346 1.9e-145 vasopressin/oxytocin receptor-like protein [Tribolium castaneum] -- -- -- -- -- K04226 AVPR1A arginine vasopressin receptor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04226 Q7YW31 649 5.2e-66 Cephalotocin receptor 1 OS=Octopus vulgaris GN=CTR1 PE=2 SV=1 PF00001//PF09446 7 transmembrane receptor (rhodopsin family)//VMA21-like domain GO:0070072//GO:0007186 vacuolar proton-transporting V-type ATPase complex assembly//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.12825 BF_2 59.88 0.79 3462 145651804 NP_001078830.1 1482 3.2e-161 inotocin receptor [Tribolium castaneum]>gi|144953865|gb|ABN79656.2| arginine vasopressin receptor [Tribolium castaneum] -- -- -- -- -- K04226 AVPR1A arginine vasopressin receptor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04226 Q7YW31 649 5.1e-66 Cephalotocin receptor 1 OS=Octopus vulgaris GN=CTR1 PE=2 SV=1 PF00001//PF09446 7 transmembrane receptor (rhodopsin family)//VMA21-like domain GO:0007186//GO:0070072//GO:0007187 G-protein coupled receptor signaling pathway//vacuolar proton-transporting V-type ATPase complex assembly//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0005000//GO:0004930 vasopressin receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.12826 BF_2 149.22 2.25 3058 91080315 XP_974396.1 3037 0.0e+00 PREDICTED: integrator complex subunit 6 [Tribolium castaneum]>gi|270005607|gb|EFA02055.1| hypothetical protein TcasGA2_TC007684 [Tribolium castaneum] 571553425 XM_395179.4 238 6.88491e-119 PREDICTED: Apis mellifera integrator complex subunit 6-like (LOC411711), transcript variant X2, mRNA K13143 INTS6, DDX26 integrator complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13143 Q9UL03 1794 7.7e-199 Integrator complex subunit 6 OS=Homo sapiens GN=INTS6 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3768 DEAD box RNA helicase Cluster-8309.12827 BF_2 47.76 0.43 4929 91080315 XP_974396.1 3268 0.0e+00 PREDICTED: integrator complex subunit 6 [Tribolium castaneum]>gi|270005607|gb|EFA02055.1| hypothetical protein TcasGA2_TC007684 [Tribolium castaneum] 571553425 XM_395179.4 238 1.11475e-118 PREDICTED: Apis mellifera integrator complex subunit 6-like (LOC411711), transcript variant X2, mRNA K13143 INTS6, DDX26 integrator complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13143 Q9UL03 1794 1.2e-198 Integrator complex subunit 6 OS=Homo sapiens GN=INTS6 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3768 DEAD box RNA helicase Cluster-8309.12829 BF_2 10.00 0.55 1041 295291554 ADF87490.1 523 1.5e-50 ferritin 1 [Eriocheir sinensis] 262401250 FJ774807.1 476 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF00210 Ferritin-like domain GO:0006879 cellular iron ion homeostasis GO:0008199 ferric iron binding -- -- -- -- Cluster-8309.12835 BF_2 1.00 1.32 304 -- -- -- -- -- 688453767 LL203361.1 35 4.3457e-07 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0013419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12845 BF_2 3.00 0.52 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1285 BF_2 8.00 0.40 1129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12851 BF_2 19.51 0.93 1169 755893212 XP_011295172.1 147 6.8e-07 PREDICTED: uncharacterized protein LOC105262278 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12856 BF_2 115.00 5.73 1127 91087275 XP_975544.1 1040 1.9e-110 PREDICTED: probable complex I intermediate-associated protein 30, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18159 NDUFAF1, CIA30 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18159 Q9VAI1 928 7.4e-99 Complex I intermediate-associated protein 30, mitochondrial OS=Drosophila melanogaster GN=CIA30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2435 Uncharacterized conserved protein Cluster-8309.12858 BF_2 3.48 0.31 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12859 BF_2 7.00 0.61 770 242002706 XP_002435996.1 249 6.7e-19 sulfotransferase, putative [Ixodes scapularis]>gi|215499332|gb|EEC08826.1| sulfotransferase, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12868 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12870 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12877 BF_2 43.84 0.52 3784 642913362 XP_008195422.1 235 1.4e-16 PREDICTED: uncharacterized protein LOC103313584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12880 BF_2 16.00 0.55 1504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04452 RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.1289 BF_2 4.00 0.38 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12890 BF_2 6.87 0.65 732 668456044 KFB44253.1 285 4.2e-23 AGAP009875-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q7M4F3 232 2.4e-18 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379//PF04186 Insect cuticle protein//FxsA cytoplasmic membrane protein -- -- GO:0042302 structural constituent of cuticle GO:0016020 membrane -- -- Cluster-8309.12895 BF_2 21.00 0.63 1691 91087947 XP_972232.1 394 2.3e-35 PREDICTED: uncharacterized protein LOC660945 [Tribolium castaneum]>gi|270011932|gb|EFA08380.1| hypothetical protein TcasGA2_TC006023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.12897 BF_2 44.01 0.47 4173 642921365 XP_972788.2 3503 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 2.17432e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1297 4.5e-141 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF00097//PF00787//PF12861//PF12678//PF13639 Zinc finger, C3HC4 type (RING finger)//PX domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Ring finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0035091//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//phosphatidylinositol binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.12898 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1290 BF_2 17.00 2.18 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12900 BF_2 28.00 4.80 531 391335054 XP_003741912.1 472 6.4e-45 PREDICTED: 40S ribosomal protein S26-like [Metaseiulus occidentalis] 194758718 XM_001961573.1 69 1.00188e-25 Drosophila ananassae GF14848 (Dana\GF14848), mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 P62856 460 6.5e-45 40S ribosomal protein S26 OS=Rattus norvegicus GN=Rps26 PE=3 SV=3 PF01922//PF01283 SRP19 protein//Ribosomal protein S26e GO:0006614//GO:0006412//GO:0042254 SRP-dependent cotranslational protein targeting to membrane//translation//ribosome biogenesis GO:0003735//GO:0008312 structural constituent of ribosome//7S RNA binding GO:0048500//GO:0005622//GO:0005840 signal recognition particle//intracellular//ribosome KOG1768 40s ribosomal protein S26 Cluster-8309.12901 BF_2 1.00 0.36 402 -- -- -- -- -- 728050539 CP009888.1 318 2.83978e-164 Pseudoalteromonas sp. OCN003 chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12903 BF_2 22.00 0.77 1489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12907 BF_2 94.76 0.69 6024 270006429 EFA02877.1 3091 0.0e+00 hypothetical protein TcasGA2_TC008029 [Tribolium castaneum] -- -- -- -- -- K17495 CSMD CUB and sushi domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K17495 P0C6B8 1414 1.8e-154 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.1291 BF_2 1.00 4.23 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12915 BF_2 3.12 0.56 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12916 BF_2 5.37 0.82 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12917 BF_2 2.88 1.19 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12919 BF_2 4.63 0.68 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12920 BF_2 2.00 0.88 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.12922 BF_2 10.00 0.53 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11382//PF06156//PF07851//PF04111//PF07544 Copper transport outer membrane protein, MctB//Protein of unknown function (DUF972)//TMPIT-like protein//Autophagy protein Apg6//RNA polymerase II transcription mediator complex subunit 9 GO:0006914//GO:0006810//GO:0006357//GO:0006260 autophagy//transport//regulation of transcription from RNA polymerase II promoter//DNA replication GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0016021 mediator complex//integral component of membrane -- -- Cluster-8309.12926 BF_2 3.00 1.10 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12927 BF_2 2.00 0.99 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12929 BF_2 45.71 2.05 1219 189237437 XP_001815618.1 867 2.3e-90 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 346 2.5e-31 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.12931 BF_2 24.00 0.53 2167 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12934 BF_2 43.71 0.44 4473 642915646 XP_008190694.1 3010 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 6.8e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.12936 BF_2 4.87 0.35 864 642928877 XP_970196.2 550 9.4e-54 PREDICTED: transmembrane protein 68 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCR6 353 2.7e-32 Transmembrane protein 68 OS=Bos taurus GN=TMEM68 PE=2 SV=1 PF01553//PF03982 Acyltransferase//Diacylglycerol acyltransferase GO:0008152 metabolic process GO:0016747//GO:0016746 transferase activity, transferring acyl groups other than amino-acyl groups//transferase activity, transferring acyl groups -- -- KOG4321 Predicted phosphate acyltransferases Cluster-8309.12937 BF_2 80.13 3.26 1314 642928877 XP_970196.2 1219 3.8e-131 PREDICTED: transmembrane protein 68 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCR6 750 3.8e-78 Transmembrane protein 68 OS=Bos taurus GN=TMEM68 PE=2 SV=1 PF03982//PF01553 Diacylglycerol acyltransferase//Acyltransferase GO:0008152 metabolic process GO:0016747//GO:0016746 transferase activity, transferring acyl groups other than amino-acyl groups//transferase activity, transferring acyl groups -- -- KOG4321 Predicted phosphate acyltransferases Cluster-8309.12940 BF_2 21.87 0.45 2337 642911851 XP_968798.2 1420 3.3e-154 PREDICTED: SRSF protein kinase 1 [Tribolium castaneum] -- -- -- -- -- K08831 SRPK2 serine/threonine-protein kinase SRPK2 http://www.genome.jp/dbget-bin/www_bget?ko:K08831 O54781 494 3.3e-48 SRSF protein kinase 2 OS=Mus musculus GN=Srpk2 PE=1 SV=2 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1290 Serine/threonine protein kinase Cluster-8309.12946 BF_2 128.00 2.11 2820 270010355 EFA06803.1 1242 1.8e-133 hypothetical protein TcasGA2_TC009742 [Tribolium castaneum] -- -- -- -- -- K11268 ESCO, ECO1 N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11268 Q8CIB9 441 5.5e-42 N-acetyltransferase ESCO2 OS=Mus musculus GN=Esco2 PE=2 SV=3 PF00583//PF13508 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3014 Protein involved in establishing cohesion between sister chromatids during DNA replication Cluster-8309.12949 BF_2 1.00 4.23 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12950 BF_2 4.00 0.50 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12954 BF_2 5.00 0.45 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12956 BF_2 10.78 0.53 1135 642924004 XP_008193965.1 762 3.2e-78 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 343 5.1e-31 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400//PF03275 WD domain, G-beta repeat//UDP-galactopyranose mutase -- -- GO:0005515//GO:0008767 protein binding//UDP-galactopyranose mutase activity -- -- KOG1188 WD40 repeat protein Cluster-8309.12957 BF_2 17.00 0.35 2295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03248//PF03526 Rer1 family//Colicin E1 (microcin) immunity protein GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0015643 toxic substance binding GO:0019814//GO:0016021 immunoglobulin complex//integral component of membrane -- -- Cluster-8309.12964 BF_2 169.92 16.09 729 642915577 XP_008190672.1 392 1.7e-35 PREDICTED: 39S ribosomal protein L52, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17433 MRPL52 large subunit ribosomal protein L52 http://www.genome.jp/dbget-bin/www_bget?ko:K17433 Q7JWG9 318 2.6e-28 39S ribosomal protein L52, mitochondrial OS=Drosophila melanogaster GN=mRpL52 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1297 BF_2 4.00 0.48 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12971 BF_2 69.35 3.28 1172 751473872 XP_011192306.1 410 2.2e-37 PREDICTED: caspase [Bactrocera cucurbitae] -- -- -- -- -- K04396 CASP6 caspase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K04396 P89116 395 4.9e-37 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.12978 BF_2 22.00 0.81 1420 642927156 XP_008195160.1 905 1.1e-94 PREDICTED: homeobox protein Hox-D4a [Tribolium castaneum]>gi|270010104|gb|EFA06552.1| hypothetical protein TcasGA2_TC009461 [Tribolium castaneum] 751798033 XM_011210610.1 57 1.30778e-18 PREDICTED: Bactrocera dorsalis uncharacterized LOC105230041 (LOC105230041), mRNA K08025 HLXB9, HB9 homeobox protein HB9 http://www.genome.jp/dbget-bin/www_bget?ko:K08025 Q9QZW9 350 9.9e-32 Motor neuron and pancreas homeobox protein 1 OS=Mus musculus GN=Mnx1 PE=2 SV=2 PF08880//PF00046 QLQ//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005524 DNA binding//ATP binding GO:0005634 nucleus KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.12982 BF_2 8.00 2.93 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.12983 BF_2 4.00 0.42 686 241703753 XP_002411960.1 214 6.8e-15 flavonol reductase/cinnamoyl-CoA reductase, putative [Ixodes scapularis]>gi|215504945|gb|EEC14439.1| flavonol reductase/cinnamoyl-CoA reductase, putative, partial [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0044237//GO:0006816//GO:0009813//GO:0055114//GO:0006874 cellular metabolic process//calcium ion transport//flavonoid biosynthetic process//oxidation-reduction process//cellular calcium ion homeostasis GO:0045552//GO:0005219//GO:0050662//GO:0000166 dihydrokaempferol 4-reductase activity//ryanodine-sensitive calcium-release channel activity//coenzyme binding//nucleotide binding GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.12986 BF_2 98.00 6.37 931 189237096 XP_970660.2 945 1.6e-99 PREDICTED: peroxiredoxin-6 [Tribolium castaneum]>gi|270008182|gb|EFA04630.1| hypothetical protein TcasGA2_TC013791 [Tribolium castaneum] 572267954 XM_006611975.1 63 3.91411e-22 PREDICTED: Apis dorsata peroxiredoxin-6-like (LOC102672292), mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 Q5ZJF4 731 4.3e-76 Peroxiredoxin-6 OS=Gallus gallus GN=PRDX6 PE=2 SV=3 PF08534//PF00578//PF10417 Redoxin//AhpC/TSA family//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.12988 BF_2 8.00 0.67 787 642931385 XP_008196557.1 178 1.2e-10 PREDICTED: zinc finger protein 827-like isoform X2 [Tribolium castaneum]>gi|270012149|gb|EFA08597.1| hypothetical protein TcasGA2_TC006256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 150 8.5e-09 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF07776//PF02150//PF04988//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//RNA polymerases M/15 Kd subunit//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003677//GO:0003899 zinc ion binding//metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.12991 BF_2 25.99 0.45 2707 642937652 XP_966876.3 431 1.9e-39 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 299 1.5e-25 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.12993 BF_2 133.00 4.80 1446 478259670 ENN79514.1 1579 7.5e-173 hypothetical protein YQE_03977, partial [Dendroctonus ponderosae]>gi|546682940|gb|ERL92819.1| hypothetical protein D910_10127 [Dendroctonus ponderosae] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q7JZB4 1484 3.2e-163 Mannose-1-phosphate guanyltransferase beta OS=Drosophila melanogaster GN=CG1129 PE=2 SV=1 PF07959//PF00483//PF01128 L-fucokinase//Nucleotidyl transferase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0050518//GO:0016779//GO:0016772 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.12998 BF_2 93.09 4.84 1092 546678229 ERL88905.1 201 3.5e-13 hypothetical protein D910_06287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11081 Protein of unknown function (DUF2890) GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.1300 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020 Ribosomal L40e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.13001 BF_2 85.93 1.09 3582 642913282 XP_008201469.1 2528 1.7e-282 PREDICTED: LOW QUALITY PROTEIN: high-affinity choline transporter 1 [Tribolium castaneum] 571538879 XM_392464.5 288 1.29567e-146 PREDICTED: Apis mellifera high-affinity choline transporter 1 (LOC408935), mRNA K14387 SLC5A7, CHT1 solute carrier family 5 (high affinity choline transporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14387 Q9VE46 2315 3.5e-259 High-affinity choline transporter 1 OS=Drosophila melanogaster GN=CG7708 PE=2 SV=2 PF00474//PF05151 Sodium:solute symporter family//Photosystem II reaction centre M protein (PsbM) GO:0019684//GO:0006810//GO:0055085//GO:0015979 photosynthesis, light reaction//transport//transmembrane transport//photosynthesis GO:0005215 transporter activity GO:0009523//GO:0016020//GO:0016021 photosystem II//membrane//integral component of membrane KOG3761 Choline transporter Cluster-8309.13005 BF_2 15.26 0.63 1302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13008 BF_2 1.00 1.40 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13012 BF_2 12.00 0.77 936 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13016 BF_2 178.00 3.40 2476 478250478 ENN70973.1 954 3.8e-100 hypothetical protein YQE_12373, partial [Dendroctonus ponderosae] -- -- -- -- -- K16745 B9D2 B9 domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16745 Q6DGZ1 379 7.5e-35 B9 domain-containing protein 2 OS=Danio rerio GN=b9d2 PE=2 SV=1 PF00705 Proliferating cell nuclear antigen, N-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding -- -- KOG4028 Uncharacterized conserved protein Cluster-8309.1302 BF_2 2.22 0.32 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537 Scorpion toxin-like domain GO:0006810 transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.13028 BF_2 9.00 5.05 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.13029 BF_2 2.00 0.41 492 675378188 KFM71090.1 194 1.0e-12 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13036 BF_2 5.00 7.30 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13037 BF_2 2.17 0.41 510 478258161 ENN78299.1 223 4.6e-16 hypothetical protein YQE_05449, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13039 BF_2 12.15 0.42 1499 478251633 ENN72090.1 307 2.5e-25 hypothetical protein YQE_11257, partial [Dendroctonus ponderosae]>gi|546674556|gb|ERL85912.1| hypothetical protein D910_03327 [Dendroctonus ponderosae] -- -- -- -- -- K06875 PDCD5, TFAR19 programmed cell death protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06875 Q93408 174 2.7e-11 Uncharacterized protein D2005.3 OS=Caenorhabditis elegans GN=D2005.3 PE=3 SV=2 PF01984 Double-stranded DNA-binding domain -- -- GO:0003677 DNA binding -- -- KOG3431 Apoptosis-related protein/predicted DNA-binding protein Cluster-8309.13047 BF_2 11.00 0.68 963 242006625 XP_002424149.1 1306 2.3e-141 Acetylcholine receptor protein subunit alpha-L1 precursor, putative [Pediculus humanus corporis]>gi|212507474|gb|EEB11411.1| Acetylcholine receptor protein subunit alpha-L1 precursor, putative [Pediculus humanus corporis] 419184293 KC134201.1 220 2.14801e-109 Lucilia cuprina clone lucu-NicRalpha2-FULL nicotinic acetylcholine receptor alpha2 subunit (nicra2) mRNA, complete cds K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P23414 1303 2.1e-142 Acetylcholine receptor subunit alpha-L1 OS=Schistocerca gregaria PE=2 SV=1 PF09127//PF02932//PF02931 Leukotriene A4 hydrolase, C-terminal//Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006812//GO:0006811//GO:0019370//GO:0007165//GO:0006810 cation transport//ion transport//leukotriene biosynthetic process//signal transduction//transport GO:0005230//GO:0008237//GO:0008270//GO:0004889 extracellular ligand-gated ion channel activity//metallopeptidase activity//zinc ion binding//acetylcholine-activated cation-selective channel activity GO:0016020//GO:0030054//GO:0045211//GO:0005886//GO:0016021 membrane//cell junction//postsynaptic membrane//plasma membrane//integral component of membrane KOG3645 Acetylcholine receptor Cluster-8309.13048 BF_2 2.00 2.21 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13049 BF_2 4.00 0.60 565 675652260 XP_008992534.1 817 6.7e-85 PREDICTED: 40S ribosomal protein S10 [Callithrix jacchus] 675697614 XM_008960611.1 565 0 PREDICTED: Pan paniscus ribosomal protein S10 (RPS10), transcript variant X1, mRNA K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 P46783 791 2.8e-83 40S ribosomal protein S10 OS=Homo sapiens GN=RPS10 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13053 BF_2 85.19 1.61 2497 546685168 ERL94695.1 216 1.5e-14 hypothetical protein D910_11970 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09334 tRNA synthetases class I (M) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- -- -- Cluster-8309.13056 BF_2 248.73 6.93 1789 478257982 ENN78120.1 236 5.0e-17 hypothetical protein YQE_05274, partial [Dendroctonus ponderosae]>gi|546682483|gb|ERL92406.1| hypothetical protein D910_09720 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.13057 BF_2 6.20 0.51 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13058 BF_2 11.72 0.40 1507 478257982 ENN78120.1 162 1.6e-08 hypothetical protein YQE_05274, partial [Dendroctonus ponderosae]>gi|546682483|gb|ERL92406.1| hypothetical protein D910_09720 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13061 BF_2 20.00 2.67 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13064 BF_2 5.94 0.36 968 478250258 ENN70758.1 214 9.6e-15 hypothetical protein YQE_12547, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13068 BF_2 37.00 0.49 3429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13073 BF_2 3.74 0.49 606 189233864 XP_972774.2 251 3.1e-19 PREDICTED: LIM and calponin homology domains-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270014752|gb|EFA11200.1| hypothetical protein TcasGA2_TC005164 [Tribolium castaneum] 642911269 XM_967681.3 143 8.42328e-67 PREDICTED: Tribolium castaneum LIM and calponin homology domains-containing protein 1 (LOC661528), transcript variant X1, mRNA -- -- -- -- Q0KIC3 161 3.5e-10 Uncharacterized protein CG43427 OS=Drosophila melanogaster GN=CG43427 PE=2 SV=1 PF03938//PF09110//PF02096//PF10186 Outer membrane protein (OmpH-like)//HAND//60Kd inner membrane protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0051205//GO:0043044 positive regulation of autophagy//protein insertion into membrane//ATP-dependent chromatin remodeling GO:0031491//GO:0051082 nucleosome binding//unfolded protein binding GO:0016021//GO:0000785 integral component of membrane//chromatin -- -- Cluster-8309.13075 BF_2 28.29 1.58 1034 546684870 ERL94452.1 181 6.9e-11 hypothetical protein D910_11729 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13086 BF_2 40.63 1.89 1187 546680629 ERL90867.1 1258 1.0e-135 hypothetical protein D910_08212 [Dendroctonus ponderosae] -- -- -- -- -- K11418 HDAC11 histone deacetylase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11418 Q9GKU5 991 3.9e-106 Histone deacetylase 11 OS=Macaca fascicularis GN=HDAC11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1344 Predicted histone deacetylase Cluster-8309.13088 BF_2 9.00 0.33 1442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08515 Transforming growth factor beta type I GS-motif GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004675//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.13094 BF_2 74.57 2.96 1342 136223 P05547.1 583 2.2e-57 RecName: Full=Troponin I; Short=TnI [Pontastacus leptodactylus]>gi|102756|pir||A31484 troponin I, fast skeletal muscle - broad-fingered crayfish 414448055 JX683730.1 408 0 Litopenaeus vannamei clone TPNi3 troponin I mRNA, complete cds -- -- -- -- P05547 583 9.0e-59 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF03776//PF00992//PF05190 Septum formation topological specificity factor MinE//Troponin//MutS family domain IV GO:0051301//GO:0006298//GO:0032955 cell division//mismatch repair//regulation of barrier septum assembly GO:0030983//GO:0005524 mismatched DNA binding//ATP binding GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.13095 BF_2 16.44 0.67 1318 136223 P05547.1 583 2.1e-57 RecName: Full=Troponin I; Short=TnI [Pontastacus leptodactylus]>gi|102756|pir||A31484 troponin I, fast skeletal muscle - broad-fingered crayfish 414448075 JX683731.1 372 0 Litopenaeus vannamei clone TPNi4 troponin I mRNA, complete cds -- -- -- -- P05547 583 8.8e-59 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992//PF03776//PF05190 Troponin//Septum formation topological specificity factor MinE//MutS family domain IV GO:0051301//GO:0006298//GO:0032955 cell division//mismatch repair//regulation of barrier septum assembly GO:0030983//GO:0005524 mismatched DNA binding//ATP binding GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.13097 BF_2 193.17 3.59 2540 642934881 XP_966430.2 1844 2.5e-203 PREDICTED: DDB1- and CUL4-associated factor 7 isoform X1 [Tribolium castaneum] 662195262 XM_008472391.1 245 7.33279e-123 PREDICTED: Diaphorina citri DDB1- and CUL4-associated factor 7 (LOC103507876), mRNA K11805 WDR68, HAN11 WD repeat-containing protein 68 http://www.genome.jp/dbget-bin/www_bget?ko:K11805 P61963 1651 2.4e-182 DDB1- and CUL4-associated factor 7 OS=Mus musculus GN=Dcaf7 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0290 Conserved WD40 repeat-containing protein AN11 Cluster-8309.13099 BF_2 8.93 0.53 989 662190115 XP_008467806.1 445 1.6e-41 PREDICTED: lactosylceramide 4-alpha-galactosyltransferase-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q9NPC4 125 8.5e-06 Lactosylceramide 4-alpha-galactosyltransferase OS=Homo sapiens GN=A4GALT PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13100 BF_2 56.07 2.21 1347 646709072 KDR15120.1 596 6.8e-59 hypothetical protein L798_11003 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12919 TcdA/TcdB catalytic glycosyltransferase domain -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.13105 BF_2 121.06 1.09 4932 642913527 XP_008201051.1 3291 0.0e+00 PREDICTED: protein timeless homolog [Tribolium castaneum]>gi|270002773|gb|EEZ99220.1| timeout [Tribolium castaneum] -- -- -- -- -- K03155 TIMELESS timeless http://www.genome.jp/dbget-bin/www_bget?ko:K03155 Q9UNS1 1789 4.7e-198 Protein timeless homolog OS=Homo sapiens GN=TIMELESS PE=1 SV=2 PF04211 Tetrahydromethanopterin S-methyltransferase, subunit C GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane KOG1974 DNA topoisomerase I-interacting protein Cluster-8309.13109 BF_2 5.00 0.82 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13110 BF_2 27.34 0.84 1645 642929186 XP_008195727.1 576 1.7e-56 PREDICTED: putative gamma-glutamylcyclotransferase CG2811 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y2 355 3.0e-32 Putative gamma-glutamylcyclotransferase CG2811 OS=Drosophila melanogaster GN=CG2811 PE=2 SV=2 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- KOG4450 Uncharacterized conserved protein Cluster-8309.13114 BF_2 8.16 0.98 634 270014574 EFA11022.1 289 1.3e-23 hypothetical protein TcasGA2_TC004610 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13116 BF_2 10.00 0.31 1632 642913056 XP_008201369.1 1397 1.1e-151 PREDICTED: anosmin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23352 500 4.6e-49 Anosmin-1 OS=Homo sapiens GN=KAL1 PE=1 SV=3 PF16656//PF00041//PF00095 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0030414//GO:0005515//GO:0046872 acid phosphatase activity//peptidase inhibitor activity//protein binding//metal ion binding GO:0005576 extracellular region KOG4802 Adhesion-type protein Cluster-8309.13118 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13119 BF_2 194.31 6.12 1615 642929319 XP_008195785.1 1373 6.5e-149 PREDICTED: stomatin-like protein 2, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UJZ1 1028 2.7e-110 Stomatin-like protein 2, mitochondrial OS=Homo sapiens GN=STOML2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2620 Prohibitins and stomatins of the PID superfamily Cluster-8309.1312 BF_2 10.00 0.31 1650 91078482 XP_975769.1 665 8.3e-67 PREDICTED: cytochrome b-c1 complex subunit 2, mitochondrial [Tribolium castaneum]>gi|270004017|gb|EFA00465.1| hypothetical protein TcasGA2_TC003323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23004 552 4.3e-55 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Bos taurus GN=UQCRC2 PE=1 SV=2 PF04444 Catechol dioxygenase N terminus GO:0055114//GO:0046232//GO:0042184//GO:0009712//GO:0042203//GO:0019261//GO:0018874 oxidation-reduction process//carbazole catabolic process//xylene catabolic process//catechol-containing compound metabolic process//toluene catabolic process//1,4-dichlorobenzene catabolic process//benzoate metabolic process GO:0018576//GO:0005506 catechol 1,2-dioxygenase activity//iron ion binding -- -- KOG2583 Ubiquinol cytochrome c reductase, subunit QCR2 Cluster-8309.13126 BF_2 90.00 1.89 2276 260782407 XP_002586279.1 599 5.1e-59 hypothetical protein BRAFLDRAFT_132313 [Branchiostoma floridae]>gi|229271379|gb|EEN42290.1| hypothetical protein BRAFLDRAFT_132313 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q8N4W9 566 1.4e-56 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF16622//PF13912//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.13130 BF_2 40.80 0.92 2140 157137465 XP_001664001.1 194 4.4e-12 AAEL013812-PA [Aedes aegypti]>gi|108869698|gb|EAT33923.1| AAEL013812-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13142 BF_2 65.71 0.57 5139 642918886 XP_008191628.1 759 3.3e-77 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 354 1.2e-31 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF05933//PF01757//PF07850 Fungal ATP synthase protein 8 (A6L)//Acyltransferase family//Renin receptor-like protein GO:0007165//GO:0015992//GO:0015986 signal transduction//proton transport//ATP synthesis coupled proton transport GO:0004872//GO:0016747//GO:0015078 receptor activity//transferase activity, transferring acyl groups other than amino-acyl groups//hydrogen ion transmembrane transporter activity GO:0016021//GO:0000276 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.13145 BF_2 3.00 4.20 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13146 BF_2 8.00 0.42 1089 675373226 KFM66128.1 145 1.1e-06 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13148 BF_2 5.00 0.72 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13150 BF_2 9.00 0.46 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13153 BF_2 56.99 0.78 3351 642924977 XP_008194123.1 501 1.8e-47 PREDICTED: myosin-6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305//PF04559//PF03233//PF14822//PF07851//PF04977//PF03623//PF00866//PF08919//PF07716//PF01025//PF06220//PF04111//PF03462//PF00170//PF06005 Protein of unknown function (DUF1049)//Herpesvirus UL17 protein//Aphid transmission protein//Vasohibin//TMPIT-like protein//Septum formation initiator//Focal adhesion targeting region//Ring hydroxylating beta subunit//F-actin binding//Basic region leucine zipper//GrpE//U1 zinc finger//Autophagy protein Apg6//PCRF domain//bZIP transcription factor//Protein of unknown function (DUF904) GO:0006415//GO:0055114//GO:0006725//GO:0007172//GO:0019089//GO:0006355//GO:0045765//GO:0006323//GO:0007049//GO:0007165//GO:0006914//GO:0006468//GO:0043093//GO:0000917//GO:0006449//GO:0006457 translational termination//oxidation-reduction process//cellular aromatic compound metabolic process//signal complex assembly//transmission of virus//regulation of transcription, DNA-templated//regulation of angiogenesis//DNA packaging//cell cycle//signal transduction//autophagy//protein phosphorylation//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of translational termination//protein folding GO:0051087//GO:0003700//GO:0005524//GO:0008270//GO:0043565//GO:0000774//GO:0042803//GO:0004871//GO:0003824//GO:0004713//GO:0004715//GO:0016149 chaperone binding//transcription factor activity, sequence-specific DNA binding//ATP binding//zinc ion binding//sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//protein homodimerization activity//signal transducer activity//catalytic activity//protein tyrosine kinase activity//non-membrane spanning protein tyrosine kinase activity//translation release factor activity, codon specific GO:0018444//GO:0005925//GO:0005667//GO:0005840//GO:0005737//GO:0016021//GO:0005887//GO:0019012 translation release factor complex//focal adhesion//transcription factor complex//ribosome//cytoplasm//integral component of membrane//integral component of plasma membrane//virion -- -- Cluster-8309.13156 BF_2 5.00 0.57 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13158 BF_2 77.00 0.82 4220 642913975 XP_008201498.1 2845 0.0e+00 PREDICTED: nicotinic acetylcholine receptor alpha4 subunit isoform X1 [Tribolium castaneum] 817213541 XM_012427580.1 503 0 PREDICTED: Orussus abietinus acetylcholine receptor subunit alpha-like (LOC105701135), transcript variant X2, mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P91766 1859 3.1e-206 Acetylcholine receptor subunit alpha-like OS=Manduca sexta GN=ARA1 PE=2 SV=1 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.1316 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13164 BF_2 4.00 0.44 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13165 BF_2 11.00 0.63 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13169 BF_2 35.00 0.40 3909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1317 BF_2 1.00 0.34 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01974 tRNA intron endonuclease, catalytic C-terminal domain GO:0006388//GO:0051252 tRNA splicing, via endonucleolytic cleavage and ligation//regulation of RNA metabolic process GO:0000213 tRNA-intron endonuclease activity GO:0000214 tRNA-intron endonuclease complex -- -- Cluster-8309.13170 BF_2 1.00 4.80 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13175 BF_2 3.00 0.37 626 196013755 XP_002116738.1 154 5.6e-08 hypothetical protein TRIADDRAFT_31339 [Trichoplax adhaerens]>gi|190580716|gb|EDV20797.1| hypothetical protein TRIADDRAFT_31339 [Trichoplax adhaerens] -- -- -- -- -- -- -- -- -- P12785 131 1.1e-06 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- GO:0006633//GO:0042967 fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016788//GO:0004312 hydrolase activity, acting on ester bonds//fatty acid synthase activity GO:0005835 fatty acid synthase complex -- -- Cluster-8309.13180 BF_2 7.44 1.27 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13181 BF_2 30.03 0.98 1568 546686115 ERL95507.1 275 1.3e-21 hypothetical protein D910_12769 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0Y6 156 3.4e-09 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF01747 ATP-sulfurylase GO:0006790//GO:0006144 sulfur compound metabolic process//purine nucleobase metabolic process GO:0004781 sulfate adenylyltransferase (ATP) activity -- -- -- -- Cluster-8309.13184 BF_2 27.22 1.01 1418 642930226 XP_008196308.1 387 1.2e-34 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 128 5.4e-06 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF13184//PF01842 NusA-like KH domain//ACT domain GO:0008152 metabolic process GO:0003723//GO:0016597 RNA binding//amino acid binding -- -- -- -- Cluster-8309.13186 BF_2 3.07 0.52 532 91089225 XP_968001.1 287 1.8e-23 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 206 1.8e-15 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4055 Uncharacterized conserved protein Cluster-8309.13194 BF_2 23.43 0.88 1396 642927860 XP_008195428.1 958 7.4e-101 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6YI48 222 6.8e-17 Receptor-type tyrosine-protein phosphatase U OS=Gallus gallus GN=PTPRU PE=2 SV=1 PF00641//PF00102 Zn-finger in Ran binding protein and others//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0004725 zinc ion binding//protein tyrosine phosphatase activity -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.13195 BF_2 17.39 0.68 1355 675369149 KFM62051.1 1655 1.1e-181 Eukaryotic initiation factor 4A-II, partial [Stegodyphus mimosarum] 110339424 DQ667140.1 1217 0 Callinectes sapidus eukaryotic initiation factor 4A mRNA, complete cds K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 P10630 1624 1.8e-179 Eukaryotic initiation factor 4A-II OS=Mus musculus GN=Eif4a2 PE=2 SV=2 PF04851//PF00579//PF00270//PF07652 Type III restriction enzyme, res subunit//tRNA synthetases class I (W and Y)//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0006418//GO:0019079 tRNA aminoacylation for protein translation//viral genome replication GO:0004812//GO:0003676//GO:0000166//GO:0008026//GO:0016787//GO:0003677//GO:0005524 aminoacyl-tRNA ligase activity//nucleic acid binding//nucleotide binding//ATP-dependent helicase activity//hydrolase activity//DNA binding//ATP binding -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.13198 BF_2 11.39 0.76 915 642920718 XP_008192534.1 265 1.1e-20 PREDICTED: LYR motif-containing protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXA0 209 1.4e-15 LYR motif-containing protein 5 OS=Taeniopygia guttata GN=LYRM5 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13203 BF_2 66.41 2.09 1615 332373040 AEE61661.1 1714 1.9e-188 unknown [Dendroctonus ponderosae]>gi|478250242|gb|ENN70742.1| hypothetical protein YQE_12531, partial [Dendroctonus ponderosae]>gi|546685939|gb|ERL95353.1| hypothetical protein D910_12618 [Dendroctonus ponderosae] -- -- -- -- -- K03142 TFIIH2, GTF2H2, SSL1 transcription initiation factor TFIIH subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03142 Q2TBV5 1122 3.4e-121 General transcription factor IIH subunit 2 OS=Bos taurus GN=GTF2H2 PE=2 SV=1 PF07975//PF07649//PF01363 TFIIH C1-like domain//C1-like domain//FYVE zinc finger GO:0055114//GO:0006281 oxidation-reduction process//DNA repair GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 Cluster-8309.13205 BF_2 225.18 2.53 4008 91079786 XP_967971.1 1583 7.2e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 8.7e-126 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0042254//GO:0006396//GO:0006030 ribosome biogenesis//RNA processing//chitin metabolic process GO:0008061//GO:0003824 chitin binding//catalytic activity GO:0005730//GO:0005576 nucleolus//extracellular region KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.13216 BF_2 77.18 1.77 2112 91087145 XP_975296.1 816 3.3e-84 PREDICTED: ATP-dependent DNA helicase 2 subunit 1 [Tribolium castaneum]>gi|270011089|gb|EFA07537.1| inverted repeat-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02735 Ku70/Ku80 beta-barrel domain GO:0006303 double-strand break repair via nonhomologous end joining GO:0003677 DNA binding -- -- -- -- Cluster-8309.13218 BF_2 61.82 1.70 1805 91087145 XP_975296.1 816 2.8e-84 PREDICTED: ATP-dependent DNA helicase 2 subunit 1 [Tribolium castaneum]>gi|270011089|gb|EFA07537.1| inverted repeat-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02735 Ku70/Ku80 beta-barrel domain GO:0006303 double-strand break repair via nonhomologous end joining GO:0003677 DNA binding -- -- -- -- Cluster-8309.13227 BF_2 76.00 2.88 1390 642914132 XP_008201558.1 589 4.5e-58 PREDICTED: uncharacterized protein C19orf52 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BSF4 201 1.8e-14 Uncharacterized protein C19orf52 OS=Homo sapiens GN=C19orf52 PE=1 SV=2 PF05373//PF02740 L-proline 3-hydroxylase, C-terminal//Colipase, C-terminal domain GO:0016042//GO:0055114//GO:0007586 lipid catabolic process//oxidation-reduction process//digestion GO:0008047//GO:0016706 enzyme activator activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0005576 extracellular region -- -- Cluster-8309.13229 BF_2 7.03 0.47 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13234 BF_2 8.00 0.32 1335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13236 BF_2 31.00 1.13 1433 391347891 XP_003748187.1 1312 6.8e-142 PREDICTED: ADP,ATP carrier protein 1-like [Metaseiulus occidentalis] 325303797 BK007724.1 284 8.55043e-145 TPA_exp: Amblyomma variegatum ADP/ATP translocase mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q27238 1278 2.5e-139 ADP,ATP carrier protein 1 OS=Anopheles gambiae GN=AGAP006782 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.13242 BF_2 51.78 1.35 1895 642940135 XP_008191977.1 2032 2.9e-225 PREDICTED: probable tyrosyl-DNA phosphodiesterase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10862 TDP1 tyrosyl-DNA phosphodiesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10862 Q9VQM4 897 4.9e-95 Probable tyrosyl-DNA phosphodiesterase OS=Drosophila melanogaster GN=gkt PE=2 SV=1 PF06087 Tyrosyl-DNA phosphodiesterase GO:0006281 DNA repair GO:0008081 phosphoric diester hydrolase activity GO:0005634 nucleus KOG2031 Tyrosyl-DNA phosphodiesterase Cluster-8309.13245 BF_2 7.00 0.44 957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13248 BF_2 2.00 1.55 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13252 BF_2 40.19 0.35 5034 672033453 XP_008756456.1 424 2.2e-38 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 160-like isoform X1, partial [Rattus norvegicus] 642924758 XM_008196206.1 138 4.42684e-63 PREDICTED: Tribolium castaneum PR domain zinc finger protein 1 (LOC100142159), transcript variant X4, mRNA -- -- -- -- Q61116 419 3.5e-39 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF13912//PF00856//PF13465//PF00096 C2H2-type zinc finger//SET domain//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- -- -- Cluster-8309.13255 BF_2 109.00 5.53 1112 91088415 XP_966747.1 343 1.2e-29 PREDICTED: nucleolar protein 12 [Tribolium castaneum]>gi|270012198|gb|EFA08646.1| hypothetical protein TcasGA2_TC006309 [Tribolium castaneum] -- -- -- -- -- K14851 RRP17, NOL12 ribosomal RNA-processing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K14851 Q8BG17 128 4.3e-06 Nucleolar protein 12 OS=Mus musculus GN=Nol12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13257 BF_2 59.77 1.28 2235 546676764 ERL87718.1 1377 3.1e-149 hypothetical protein D910_05108 [Dendroctonus ponderosae] -- -- -- -- -- K08588 BAP1, UCHL2 ubiquitin carboxyl-terminal hydrolase BAP1 http://www.genome.jp/dbget-bin/www_bget?ko:K08588 Q17N72 678 1.4e-69 Ubiquitin carboxyl-terminal hydrolase calypso OS=Aedes aegypti GN=calypso PE=3 SV=1 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006508//GO:0006511//GO:0016579 proteolysis//ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0004843 ubiquitin-specific protease activity GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.13263 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13266 BF_2 11.00 1.04 728 557776740 XP_005188008.1 320 3.7e-27 PREDICTED: cytochrome c oxidase subunit NDUFA4-like [Musca domestica] -- -- -- -- -- K03948 NDUFA4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03948 Q62425 168 6.4e-11 Cytochrome c oxidase subunit NDUFA4 OS=Mus musculus GN=Ndufa4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13268 BF_2 4.18 0.31 855 478256737 ENN76918.1 293 5.9e-24 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 1.69052e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13273 BF_2 30.83 0.67 2200 642913117 XP_008201398.1 1390 9.4e-151 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.5e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13274 BF_2 71.00 3.91 1046 478260367 ENN80114.1 1173 6.5e-126 hypothetical protein YQE_03473, partial [Dendroctonus ponderosae]>gi|546676629|gb|ERL87593.1| hypothetical protein D910_04984 [Dendroctonus ponderosae] 195380648 XM_002049047.1 97 5.55296e-41 Drosophila virilis mus209 (Dvir\mus209), mRNA K04802 PCNA proliferating cell nuclear antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04802 P17917 1096 2.3e-118 Proliferating cell nuclear antigen OS=Drosophila melanogaster GN=PCNA PE=1 SV=2 PF04139//PF00705//PF02747 Rad9//Proliferating cell nuclear antigen, N-terminal domain//Proliferating cell nuclear antigen, C-terminal domain GO:0000077//GO:0006275 DNA damage checkpoint//regulation of DNA replication GO:0003677 DNA binding GO:0030896 checkpoint clamp complex KOG1636 DNA polymerase delta processivity factor (proliferating cell nuclear antigen) Cluster-8309.13275 BF_2 28.00 1.79 943 226968617 YP_002808566.1 837 5.4e-87 ATP synthase F0 subunit 6 [Scylla paramamosain]>gi|225697853|gb|ACO07220.1| ATP synthase F0 subunit 6 [Scylla paramamosain]>gi|403311092|gb|AFR34051.1| ATP synthase F0 subunit 6 (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 940 0 Scylla paramamosain mitochondrion, complete genome K02126 ATPeF0A, MTATP6, ATP6 F-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02126 P33507 620 3.2e-63 ATP synthase subunit a OS=Anopheles quadrimaculatus GN=ATP6 PE=3 SV=1 PF00895 ATP synthase protein 8 GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276//GO:0045263//GO:0005743 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//proton-transporting ATP synthase complex, coupling factor F(o)//mitochondrial inner membrane KOG4665 ATP synthase F0 subunit 6 and related proteins Cluster-8309.13279 BF_2 15.00 2.85 507 71067609 AAZ22828.1 323 1.2e-27 lymphoid organ expressed yellow head virus receptor protein [Penaeus monodon] 874473734 XM_005019619.2 50 3.4867e-15 PREDICTED: Anas platyrhynchos ribosomal protein L22-like 1 (RPL22L1), mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 255 3.7e-21 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3434 60S ribosomal protein L22 Cluster-8309.13282 BF_2 194.42 4.65 2035 332375354 AEE62818.1 512 5.6e-49 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CY62 312 3.6e-27 E3 ubiquitin-protein ligase RNF181 OS=Mus musculus GN=Rnf181 PE=2 SV=1 PF11789//PF00097//PF17122//PF17123//PF12906//PF12678//PF00628//PF14634//PF13639//PF03854//PF12861 Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain//Ring finger domain//P-11 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0003723//GO:0005515//GO:0046872//GO:0004842 zinc ion binding//RNA binding//protein binding//metal ion binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.13291 BF_2 3.88 0.92 464 642915433 XP_008190613.1 259 2.8e-20 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13673//PF08445//PF13508//PF00583 Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-8309.13292 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13296 BF_2 35.44 0.51 3215 58389743 XP_317249.2 1838 1.6e-202 AGAP008223-PA [Anopheles gambiae str. PEST]>gi|55237464|gb|EAA12458.2| AGAP008223-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q5T2S8 1441 6.9e-158 Armadillo repeat-containing protein 4 OS=Homo sapiens GN=ARMC4 PE=1 SV=1 PF01602//PF00514//PF11698//PF10508//PF03739//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Proteasome non-ATPase 26S subunit//Predicted permease YjgP/YjgQ family//HEAT repeat GO:0043248//GO:0015991//GO:0006886//GO:0016192 proteasome assembly//ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle-mediated transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030117//GO:0016021//GO:0000221 membrane coat//integral component of membrane//vacuolar proton-transporting V-type ATPase, V1 domain KOG0167 FOG: Armadillo/beta-catenin-like repeats Cluster-8309.13302 BF_2 4.00 0.74 514 642940025 XP_008191587.1 209 1.9e-14 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 134 4.0e-07 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1264 Phospholipase C Cluster-8309.13305 BF_2 31.00 0.63 2362 288440 CAA51290.1 432 1.2e-39 acp-22 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P26968 423 5.6e-40 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 PF00379//PF07415 Insect cuticle protein//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0042302 structural constituent of cuticle GO:0033644 host cell membrane -- -- Cluster-8309.13307 BF_2 91.77 11.64 617 91085373 XP_971748.1 502 2.5e-48 PREDICTED: CDGSH iron-sulfur domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|270008416|gb|EFA04864.1| hypothetical protein TcasGA2_TC014918 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AR13 241 1.9e-19 CDGSH iron-sulfur domain-containing protein 3, mitochondrial OS=Mus musculus GN=Cisd3 PE=1 SV=1 PF09360 Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG4605 Uncharacterized conserved protein containing CDGSH-type Zn-finger Cluster-8309.13310 BF_2 63.99 0.58 4916 478257469 ENN77625.1 1057 8.7e-112 hypothetical protein YQE_05919, partial [Dendroctonus ponderosae]>gi|546679863|gb|ERL90251.1| hypothetical protein D910_07603 [Dendroctonus ponderosae] -- -- -- -- -- K11502 CENPJ centromere protein J http://www.genome.jp/dbget-bin/www_bget?ko:K11502 Q9HC77 558 2.6e-55 Centromere protein J OS=Homo sapiens GN=CENPJ PE=1 SV=2 PF01395//PF06305//PF16331 PBP/GOBP family//Protein of unknown function (DUF1049)//TolA binding protein trimerisation GO:0070206 protein trimerization GO:0005549 odorant binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.13312 BF_2 366.00 11.02 1677 91082969 XP_973818.1 1001 9.2e-106 PREDICTED: ubiquitin-conjugating enzyme E2 J2 [Tribolium castaneum]>gi|270007042|gb|EFA03490.1| hypothetical protein TcasGA2_TC013489 [Tribolium castaneum] -- -- -- -- -- K04554 UBE2J2, NCUBE2, UBC6 ubiquitin-conjugating enzyme E2 J2 http://www.genome.jp/dbget-bin/www_bget?ko:K04554 Q8N2K1 777 3.6e-81 Ubiquitin-conjugating enzyme E2 J2 OS=Homo sapiens GN=UBE2J2 PE=1 SV=3 -- -- -- -- GO:0016881 acid-amino acid ligase activity -- -- KOG0894 Ubiquitin-protein ligase Cluster-8309.13314 BF_2 172.48 2.44 3245 642927336 XP_974968.2 1448 2.6e-157 PREDICTED: protein prune homolog 2 [Tribolium castaneum] -- -- -- -- -- K18449 PRUNE2, BMCC1 prune homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18449 Q5BJR4 507 1.4e-49 Protein prune homolog 2 OS=Rattus norvegicus GN=Prune2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13320 BF_2 4.00 0.35 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13326 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13328 BF_2 13.00 0.51 1356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02805 Metal binding domain of Ada GO:0006355//GO:0006281 regulation of transcription, DNA-templated//DNA repair GO:0003677//GO:0008168//GO:0008270 DNA binding//methyltransferase activity//zinc ion binding -- -- -- -- Cluster-8309.13331 BF_2 1.00 0.34 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13337 BF_2 7.00 0.44 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13338 BF_2 50.60 2.69 1074 478254654 ENN74895.1 839 3.6e-87 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae] 817052986 XM_012404120.1 175 2.49125e-84 PREDICTED: Athalia rosae SUMO-conjugating enzyme UBC9-B (LOC105688078), mRNA K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 Q9DDJ0 751 2.4e-78 SUMO-conjugating enzyme UBC9-B OS=Danio rerio GN=ube2ib PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.13340 BF_2 28.49 0.77 1843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13341 BF_2 3.00 2.44 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13343 BF_2 57.27 1.21 2261 91083483 XP_971803.1 1715 2.0e-188 PREDICTED: tubulin polyglutamylase TTLL4 [Tribolium castaneum]>gi|270010834|gb|EFA07282.1| hypothetical protein TcasGA2_TC014517 [Tribolium castaneum] -- -- -- -- -- K16610 TTLL15 tubulin monoglycylase TTLL15 http://www.genome.jp/dbget-bin/www_bget?ko:K16610 A4Q9E8 267 6.6e-22 Tubulin polyglutamylase TTLL6 OS=Mus musculus GN=Ttll6 PE=2 SV=1 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.13345 BF_2 17.00 0.73 1267 642928982 XP_972386.2 1015 1.7e-107 PREDICTED: myrosinase 1-like [Tribolium castaneum] 336295553 CP002869.1 34 7.1011e-06 Paenibacillus mucilaginosus KNP414, complete genome K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 853 4.2e-90 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.13346 BF_2 168.09 6.79 1323 91092522 XP_971244.1 767 9.9e-79 PREDICTED: pleckstrin homology domain-containing family A member 3 isoform X2 [Tribolium castaneum]>gi|270012906|gb|EFA09354.1| hypothetical protein TcasGA2_TC001680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ERS4 573 1.3e-57 Pleckstrin homology domain-containing family A member 3 OS=Mus musculus GN=Plekha3 PE=2 SV=1 -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.13347 BF_2 21.91 0.52 2041 642934345 XP_008198611.1 490 2.0e-46 PREDICTED: pleckstrin homology domain-containing family A member 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08051 PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08051 Q9ERS4 374 2.3e-34 Pleckstrin homology domain-containing family A member 3 OS=Mus musculus GN=Plekha3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1737 Oxysterol-binding protein Cluster-8309.13351 BF_2 66.29 0.54 5407 164698394 NP_001106934.1 1464 6.1e-159 timeless isoform A [Tribolium castaneum]>gi|140270872|gb|ABO86540.1| TIMELESS isoform A [Tribolium castaneum] -- -- -- -- -- K12074 TIM timeless http://www.genome.jp/dbget-bin/www_bget?ko:K12074 P49021 1125 5.1e-121 Protein timeless OS=Drosophila melanogaster GN=tim PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13353 BF_2 66.22 8.83 601 195117344 XP_002003207.1 173 3.4e-10 GI17786 [Drosophila mojavensis]>gi|193913782|gb|EDW12649.1| GI17786 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13359 BF_2 10.00 0.87 769 195542173 ACF98297.1 891 2.4e-93 heat shock protein 70 [Eriocheir sinensis] 418206098 JX913782.1 759 0 Scylla paramamosain isolate S6 heat shock protein 70 (hsp70) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P47773 776 2.1e-81 Heat shock cognate 71 kDa protein OS=Ictalurus punctatus GN=hsc70 PE=2 SV=1 PF02491//PF04625 SHS2 domain inserted in FTSA//DEC-1 protein, N-terminal region GO:0007304//GO:0007049 chorion-containing eggshell formation//cell cycle GO:0005515//GO:0005213 protein binding//structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.1336 BF_2 3.00 0.38 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13360 BF_2 8.00 11.68 299 170585537 XP_001897539.1 323 6.8e-28 60S ribosomal protein L38 [Brugia malayi]>gi|402588086|gb|EJW82020.1| ribosomal protein L38e [Wuchereria bancrofti]>gi|671408505|emb|CDP98234.1| Protein BM-RPL-38, isoform a [Brugia malayi] 585661014 XM_006886393.1 112 6.69743e-50 PREDICTED: Elephantulus edwardii ribosomal protein L38 (RPL38), mRNA K02923 RP-L38e, RPL38 large subunit ribosomal protein L38e http://www.genome.jp/dbget-bin/www_bget?ko:K02923 Q95V84 309 1.2e-27 60S ribosomal protein L38 OS=Branchiostoma belcheri GN=RPL38 PE=3 SV=1 PF01781 Ribosomal L38e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3499 60S ribosomal protein L38 Cluster-8309.13362 BF_2 2.00 0.93 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13374 BF_2 2.00 0.33 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13379 BF_2 22.46 0.47 2274 642912135 XP_008200821.1 2047 6.4e-227 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C9W3 1000 6.7e-107 A disintegrin and metalloproteinase with thrombospondin motifs 2 OS=Mus musculus GN=Adamts2 PE=1 SV=2 PF08686//PF05372 PLAC (protease and lacunin) domain//Delta lysin family GO:0019836 hemolysis by symbiont of host erythrocytes GO:0008233 peptidase activity GO:0005576 extracellular region -- -- Cluster-8309.13386 BF_2 115.34 3.95 1509 546682615 ERL92532.1 1415 8.2e-154 hypothetical protein D910_09845 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q499P8 634 1.2e-64 RUS1 family protein C16orf58 homolog OS=Rattus norvegicus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4249 Uncharacterized conserved protein Cluster-8309.13387 BF_2 44.77 8.25 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13388 BF_2 8.06 0.34 1265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13393 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1340 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00616 GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity -- -- -- -- -- -- Cluster-8309.13402 BF_2 2.00 0.41 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13407 BF_2 5.00 0.35 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13409 BF_2 193.87 3.23 2796 642921468 XP_974644.2 1126 4.9e-120 PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I [Tribolium castaneum]>gi|642921470|ref|XP_008192881.1| PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I [Tribolium castaneum] -- -- -- -- -- K10158 B3GAT3 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10158 O97422 602 1.2e-60 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I OS=Drosophila melanogaster GN=GlcAT-I PE=2 SV=2 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.13410 BF_2 68.13 1.15 2772 642921468 XP_974644.2 1126 4.9e-120 PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I [Tribolium castaneum]>gi|642921470|ref|XP_008192881.1| PREDICTED: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I [Tribolium castaneum] -- -- -- -- -- K10158 B3GAT3 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10158 O97422 602 1.2e-60 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase I OS=Drosophila melanogaster GN=GlcAT-I PE=2 SV=2 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.13412 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13413 BF_2 8.28 0.62 850 189237193 XP_001808466.1 576 8.9e-57 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Tribolium castaneum] -- -- -- -- -- K09008 NDUFAF3 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09008 A1L1F1 232 2.8e-18 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Danio rerio GN=ndufaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3363 Uncharacterized conserved nuclear protein Cluster-8309.13422 BF_2 73.36 0.90 3692 478249945 ENN70452.1 1354 2.4e-146 hypothetical protein YQE_12955, partial [Dendroctonus ponderosae] 242018772 XM_002429803.1 87 7.26185e-35 Pediculus humanus corporis conserved hypothetical protein, mRNA K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8IWX8 487 3.3e-47 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens GN=CHERP PE=1 SV=3 PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.13426 BF_2 51.96 0.82 2949 642923183 XP_008193645.1 1527 1.6e-166 PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923185|ref|XP_008193646.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923187|ref|XP_008193647.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923189|ref|XP_008193648.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3Z5L6 617 2.2e-62 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.13427 BF_2 144.05 1.58 4103 642923183 XP_008193645.1 2040 7.5e-226 PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923185|ref|XP_008193646.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923187|ref|XP_008193647.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum]>gi|642923189|ref|XP_008193648.1| PREDICTED: MFS-type transporter SLC18B1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3Z5L6 711 3.9e-73 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.13428 BF_2 17.00 0.37 2233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13445 BF_2 3.00 0.45 565 391344026 XP_003746305.1 404 5.2e-37 PREDICTED: ubiquitin-like protein FUBI-like isoform 1 [Metaseiulus occidentalis]>gi|391344028|ref|XP_003746306.1| PREDICTED: ubiquitin-like protein FUBI-like isoform 2 [Metaseiulus occidentalis]>gi|391344030|ref|XP_003746307.1| PREDICTED: ubiquitin-like protein FUBI-like isoform 3 [Metaseiulus occidentalis] 389608234 AK401107.1 107 8.04395e-47 Papilio xuthus mRNA for ribosomal protein S30, complete cds, sequence id: Px-0113 K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 P62863 231 2.5e-18 40S ribosomal protein S30 OS=Sus scrofa GN=FAU PE=3 SV=1 PF00240//PF04758 Ubiquitin family//Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-8309.13450 BF_2 13.00 2.15 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13455 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13459 BF_2 114.00 3.25 1753 642911684 XP_008200700.1 1019 7.9e-108 PREDICTED: prohormone-4 [Tribolium castaneum]>gi|270015131|gb|EFA11579.1| brain peptide IDL-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P85831 845 4.9e-89 Prohormone-4 OS=Apis mellifera PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13461 BF_2 88.00 1.93 2190 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13471 BF_2 52.98 0.36 6485 642912859 XP_008201283.1 280 1.4e-21 PREDICTED: diacylglycerol kinase theta isoform X1 [Tribolium castaneum] 642912874 XM_008203070.1 303 1.08042e-154 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- KOG1169 Diacylglycerol kinase Cluster-8309.13475 BF_2 112.25 1.39 3654 91089205 XP_966919.1 857 1.0e-88 PREDICTED: SPRY domain-containing SOCS box protein 3 [Tribolium castaneum]>gi|270012469|gb|EFA08917.1| hypothetical protein TcasGA2_TC006623 [Tribolium castaneum] -- -- -- -- -- K10345 SPSB3, SSB3 SPRY domain-containing SOCS box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10345 Q28DT9 420 1.9e-39 SPRY domain-containing SOCS box protein 3 OS=Xenopus tropicalis GN=spsb3 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13479 BF_2 1.83 0.35 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13486 BF_2 169.22 4.13 2002 332376342 AEE63311.1 1464 2.3e-159 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 1300 9.7e-142 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.13488 BF_2 406.28 9.06 2163 478254777 ENN75013.1 1536 1.1e-167 hypothetical protein YQE_08329, partial [Dendroctonus ponderosae] -- -- -- -- -- K11536 SLC28A pyrimidine nucleoside transport protein http://www.genome.jp/dbget-bin/www_bget?ko:K11536 Q62773 866 2.2e-91 Sodium/nucleoside cotransporter 2 OS=Rattus norvegicus GN=Slc28a2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3747 Concentrative Na+-nucleoside cotransporter CNT1/CNT2 Cluster-8309.13489 BF_2 36.00 1.65 1199 546683634 ERL93422.1 1037 4.4e-110 hypothetical protein D910_10714 [Dendroctonus ponderosae] -- -- -- -- -- K15336 TRDMT1, DNMT2 tRNA (cytosine38-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15336 Q7YS61 644 6.7e-66 tRNA (cytosine-5-)-methyltransferase OS=Bos taurus GN=TRDMT1 PE=2 SV=1 PF09445 RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0008168 methyltransferase activity -- -- KOG0919 C-5 cytosine-specific DNA methylase Cluster-8309.13498 BF_2 262.08 5.92 2138 642916240 XP_008190943.1 1142 5.3e-122 PREDICTED: uncharacterized protein C630.12 [Tribolium castaneum]>gi|642916242|ref|XP_008190944.1| PREDICTED: uncharacterized protein C630.12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2I2M6 138 5.7e-07 Metallophosphoesterase 1 OS=Ailuropoda melanoleuca GN=MPPE1 PE=3 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.13503 BF_2 16.02 5.29 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13508 BF_2 18.09 2.62 576 642923855 XP_008193907.1 350 9.7e-31 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum] -- -- -- -- -- K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 129 1.7e-06 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF01363//PF00643//PF07975 FYVE zinc finger//B-box zinc finger//TFIIH C1-like domain GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.13512 BF_2 129.34 1.61 3639 642919949 XP_008192140.1 1977 1.3e-218 PREDICTED: protein ovo isoform X2 [Tribolium castaneum] 524990254 XM_005042954.1 45 1.59359e-11 PREDICTED: Ficedula albicollis ovo-like 2 (Drosophila) (OVOL2), mRNA K09216 OVOL ovo http://www.genome.jp/dbget-bin/www_bget?ko:K09216 P51521 760 7.3e-79 Protein ovo OS=Drosophila melanogaster GN=ovo PE=1 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.13513 BF_2 27.00 5.97 476 296317355 NP_001171757.1 483 3.0e-46 40S ribosomal protein S24 [Saccoglossus kowalevskii] 268306387 GU084282.1 64 5.3763e-23 Manduca sexta ribosomal protein S24 (rps24) mRNA, complete cds K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 O42387 474 1.4e-46 40S ribosomal protein S24 OS=Takifugu rubripes GN=rps24 PE=3 SV=1 PF01282 Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3424 40S ribosomal protein S24 Cluster-8309.13514 BF_2 7.00 0.44 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13517 BF_2 14.61 1.18 806 270013519 EFA09967.1 1111 7.8e-119 hypothetical protein TcasGA2_TC012125 [Tribolium castaneum] 808128212 XM_003397438.2 80 1.19456e-31 PREDICTED: Bombus terrestris 4-aminobutyrate aminotransferase, mitochondrial (LOC100648639), mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 P80147 803 1.7e-84 4-aminobutyrate aminotransferase, mitochondrial OS=Sus scrofa GN=ABAT PE=1 SV=2 PF00202//PF00155 Aminotransferase class-III//Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170//GO:0008483 pyridoxal phosphate binding//transaminase activity -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.1352 BF_2 15.00 0.54 1457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13526 BF_2 34.47 0.72 2300 642919953 XP_008192142.1 1339 8.1e-145 PREDICTED: protein ovo isoform X4 [Tribolium castaneum] 524990254 XM_005042954.1 42 4.66238e-10 PREDICTED: Ficedula albicollis ovo-like 2 (Drosophila) (OVOL2), mRNA K09216 OVOL ovo http://www.genome.jp/dbget-bin/www_bget?ko:K09216 P51521 284 7.2e-24 Protein ovo OS=Drosophila melanogaster GN=ovo PE=1 SV=2 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- KOG3576 Ovo and related transcription factors Cluster-8309.13529 BF_2 70.00 1.43 2336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08500 Tombusvirus p33 GO:0006144 purine nucleobase metabolic process GO:0003968 RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.13531 BF_2 45.85 1.06 2091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005743//GO:0005750 mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-8309.13533 BF_2 28.00 1.07 1383 478263199 ENN81589.1 679 1.7e-68 hypothetical protein YQE_01999, partial [Dendroctonus ponderosae]>gi|546674113|gb|ERL85583.1| hypothetical protein D910_03002 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01881 CRISPR associated protein Cas6 -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.13534 BF_2 3.00 4.67 296 620952856 XP_001508904.2 389 1.5e-35 PREDICTED: polyubiquitin-B [Ornithorhynchus anatinus]>gi|620983603|ref|XP_007658838.1| PREDICTED: polyubiquitin-B isoform X1 [Ornithorhynchus anatinus] 694894240 XM_003949795.2 232 1.29822e-116 PREDICTED: Pan troglodytes ribosomal protein S27a (RPS27A), transcript variant X1, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CG68 387 1.0e-36 Polyubiquitin-C OS=Sus scrofa GN=UBC PE=2 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.13538 BF_2 3.00 13.51 256 802981656 XP_004003625.2 282 3.3e-23 PREDICTED: ubiquitin-40S ribosomal protein S27a isoform X1, partial [Ovis aries] 211948006 EU794671.1 256 5.01386e-130 Homo sapiens epididymis luminal protein 112 (HEL112) mRNA, complete cds K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P62992 282 1.4e-24 Ubiquitin-40S ribosomal protein S27a OS=Bos taurus GN=RPS27A PE=1 SV=2 PF01599 Ribosomal protein S27a GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.1354 BF_2 16.70 0.46 1812 642928884 XP_008195602.1 1110 2.3e-118 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13542 BF_2 42.00 1.21 1738 642912489 XP_008200886.1 1502 7.7e-164 PREDICTED: Fanconi anemia group I protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K368 476 3.0e-46 Fanconi anemia group I protein homolog OS=Mus musculus GN=Fanci PE=1 SV=2 PF04371 Porphyromonas-type peptidyl-arginine deiminase GO:0006807//GO:0009446 nitrogen compound metabolic process//putrescine biosynthetic process GO:0004668 protein-arginine deiminase activity -- -- KOG4553 Uncharacterized conserved protein Cluster-8309.13546 BF_2 17.00 3.80 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13547 BF_2 5.44 0.93 532 478260310 ENN80062.1 394 7.1e-36 hypothetical protein YQE_03538, partial [Dendroctonus ponderosae]>gi|546678010|gb|ERL88734.1| hypothetical protein D910_06116 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13548 BF_2 11.00 1.35 628 506965582 AGM32143.1 809 6.3e-84 60S ribosomal protein L11 [Coptotermes formosanus] 768414771 XM_011549604.1 188 8.44325e-92 PREDICTED: Plutella xylostella 60S ribosomal protein L11 (LOC105380107), mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 Q3T087 782 3.5e-82 60S ribosomal protein L11 OS=Bos taurus GN=RPL11 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-8309.13552 BF_2 27.10 0.47 2707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00616 GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity -- -- -- -- -- -- Cluster-8309.13556 BF_2 33.30 0.82 1978 795015935 XP_011858320.1 892 4.7e-93 PREDICTED: uncharacterized protein LOC105555888 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.1356 BF_2 11.15 0.31 1799 642928884 XP_008195602.1 1110 2.3e-118 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13561 BF_2 12.00 1.19 710 149286914 ABR23356.1 809 7.1e-84 60s ribosomal protein L15 [Ornithodoros parkeri] -- -- -- -- -- K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 Q7T3N2 677 6.0e-70 60S ribosomal protein L15 OS=Monopterus albus GN=rpl15 PE=2 SV=3 PF00827 Ribosomal L15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.13565 BF_2 28.73 0.85 1707 642922919 XP_008200452.1 634 3.4e-63 PREDICTED: uncharacterized protein LOC103314926 [Tribolium castaneum] -- -- -- -- -- K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9BX70 218 2.4e-16 BTB/POZ domain-containing protein 2 OS=Homo sapiens GN=BTBD2 PE=1 SV=1 PF02214//PF00651 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.13572 BF_2 43.00 2.01 1182 478253464 ENN73791.1 1163 1.1e-124 hypothetical protein YQE_09571, partial [Dendroctonus ponderosae] -- -- -- -- -- K10743 RNASEH2A ribonuclease H2 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K10743 Q9VPP5 925 1.7e-98 Ribonuclease H2 subunit A OS=Drosophila melanogaster GN=CG13690 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2299 Ribonuclease HI Cluster-8309.13584 BF_2 207.83 1.27 7145 642937579 XP_008199106.1 1348 2.3e-145 PREDICTED: protein bric-a-brac 1-like isoform X1 [Tribolium castaneum]>gi|270001234|gb|EEZ97681.1| hypothetical protein TcasGA2_TC016226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B87 360 3.4e-32 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00644//PF13851//PF04871//PF05485//PF00651//PF03938//PF10473 Poly(ADP-ribose) polymerase catalytic domain//Growth-arrest specific micro-tubule binding//Uso1 / p115 like vesicle tethering protein, C terminal region//THAP domain//BTB/POZ domain//Outer membrane protein (OmpH-like)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0048870//GO:0006886//GO:0015031 cell motility//intracellular protein transport//protein transport GO:0005515//GO:0003676//GO:0042803//GO:0003950//GO:0045502//GO:0008134//GO:0008565//GO:0051082 protein binding//nucleic acid binding//protein homodimerization activity//NAD+ ADP-ribosyltransferase activity//dynein binding//transcription factor binding//protein transporter activity//unfolded protein binding GO:0030286//GO:0005667//GO:0016020//GO:0031514//GO:0005737 dynein complex//transcription factor complex//membrane//motile cilium//cytoplasm -- -- Cluster-8309.13585 BF_2 25.00 0.87 1485 395484809 AFN66649.1 1733 1.1e-190 glutamine synthetase [Fenneropenaeus chinensis]>gi|395484811|gb|AFN66650.1| glutamine synthetase [Fenneropenaeus chinensis] 347327118 JN620540.1 485 0 Litopenaeus vannamei glutamine synthetase mRNA, complete cds K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 Q04831 1669 1.2e-184 Glutamine synthetase OS=Panulirus argus PE=2 SV=1 PF03951//PF00120 Glutamine synthetase, beta-Grasp domain//Glutamine synthetase, catalytic domain GO:0009252//GO:0006807//GO:0006542 peptidoglycan biosynthetic process//nitrogen compound metabolic process//glutamine biosynthetic process GO:0004356 glutamate-ammonia ligase activity -- -- KOG0683 Glutamine synthetase Cluster-8309.13586 BF_2 80.00 11.35 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13594 BF_2 39.00 0.87 2171 531446277 AGT57843.1 1697 2.3e-186 cytochrome P450 314a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10723 SHD, CYP314A1 ecdysone 20-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K10723 Q9VUF8 1022 1.8e-109 Ecdysone 20-monooxygenase OS=Drosophila melanogaster GN=shd PE=1 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.13596 BF_2 19.35 0.31 2899 642926872 XP_008195048.1 2591 6.8e-290 PREDICTED: 43 kDa receptor-associated protein of the synapse homolog [Tribolium castaneum] 817082237 XM_012408246.1 141 5.45039e-65 PREDICTED: Athalia rosae 43 kDa receptor-associated protein of the synapse homolog (LOC105690467), mRNA -- -- -- -- Q09485 664 7.8e-68 43 kDa receptor-associated protein of the synapse homolog OS=Caenorhabditis elegans GN=rpy-1 PE=1 SV=1 PF00097//PF13181//PF10579//PF14634//PF00515//PF13374//PF13639//PF13414//PF13176 Zinc finger, C3HC4 type (RING finger)//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//zinc-RING finger domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Ring finger domain//TPR repeat//Tetratricopeptide repeat GO:0007268 synaptic transmission GO:0008270//GO:0033130//GO:0043495//GO:0046872//GO:0005515 zinc ion binding//acetylcholine receptor binding//protein anchor//metal ion binding//protein binding -- -- KOG1941 Acetylcholine receptor-associated protein of the synapse (rapsyn) Cluster-8309.13598 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13600 BF_2 4.00 0.57 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13602 BF_2 9.00 7.10 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13958 Toxin ToxN, type III toxin-antitoxin system GO:0051252 regulation of RNA metabolic process GO:0003723//GO:0004521 RNA binding//endoribonuclease activity -- -- -- -- Cluster-8309.13607 BF_2 12.20 0.33 1825 91084637 XP_974735.1 1401 4.2e-152 PREDICTED: protein FAM188A homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWN5 1047 1.9e-112 Protein FAM188A homolog OS=Drosophila melanogaster GN=CG7332 PE=1 SV=1 PF13499//PF00036//PF13405 EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG2871 Uncharacterized conserved protein Cluster-8309.13610 BF_2 183.35 6.47 1472 478251980 ENN72416.1 615 4.6e-61 hypothetical protein YQE_10934, partial [Dendroctonus ponderosae] -- -- -- -- -- K16599 TTLL1 tubulin polyglutamylase TTLL1 http://www.genome.jp/dbget-bin/www_bget?ko:K16599 Q5TUE9 553 3.0e-55 Probable 39S ribosomal protein L23, mitochondrial OS=Anopheles gambiae GN=mRpL23 PE=3 SV=1 PF03133//PF00276 Tubulin-tyrosine ligase family//Ribosomal protein L23 GO:0006464//GO:0006412//GO:0042254 cellular protein modification process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG4089 Predicted mitochondrial ribosomal protein L23 Cluster-8309.13612 BF_2 76.09 42.69 358 91078218 XP_969246.1 393 6.2e-36 PREDICTED: ubiquitin-like protein 5 [Tribolium castaneum]>gi|270002984|gb|EEZ99431.1| hypothetical protein TcasGA2_TC030562 [Tribolium castaneum] 815820526 XM_012376058.1 88 1.79654e-36 PREDICTED: Linepithema humile ubiquitin-like protein 5 (LOC105677441), mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q791B0 357 3.8e-33 Ubiquitin-like protein 5 OS=Psammomys obesus GN=UBL5 PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-8309.13615 BF_2 81.00 6.36 820 91076388 XP_968260.1 670 1.1e-67 PREDICTED: beta-sarcoglycan [Tribolium castaneum]>gi|270002457|gb|EEZ98904.1| hypothetical protein TcasGA2_TC004520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82349 165 1.6e-10 Beta-sarcoglycan OS=Mus musculus GN=Sgcb PE=1 SV=1 PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.13616 BF_2 12.00 2.95 457 91076388 XP_968260.1 233 2.8e-17 PREDICTED: beta-sarcoglycan [Tribolium castaneum]>gi|270002457|gb|EEZ98904.1| hypothetical protein TcasGA2_TC004520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016012//GO:0016021//GO:0044425 sarcoglycan complex//integral component of membrane//membrane part -- -- Cluster-8309.13618 BF_2 43.59 1.39 1603 300394168 ADK11710.1 732 1.4e-74 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- K01257 LNPEP cystinyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01257 Q32LQ0 551 5.5e-55 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.13619 BF_2 31.38 1.07 1515 300394168 ADK11710.1 677 3.1e-68 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- K01257 LNPEP cystinyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01257 Q32LQ0 510 2.9e-50 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.13628 BF_2 294.98 8.06 1818 91081441 XP_973723.1 1779 6.1e-196 PREDICTED: transmembrane protein 184C [Tribolium castaneum]>gi|270006131|gb|EFA02579.1| hypothetical protein TcasGA2_TC008297 [Tribolium castaneum] 749794019 XM_011152023.1 61 1.00612e-20 PREDICTED: Harpegnathos saltator transmembrane protein 184C (LOC105189732), transcript variant X4, mRNA -- -- -- -- Q3TPR7 949 4.4e-101 Transmembrane protein 184C OS=Mus musculus GN=Tmem184c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.13629 BF_2 21.20 0.52 1981 91081441 XP_973723.1 1325 2.9e-143 PREDICTED: transmembrane protein 184C [Tribolium castaneum]>gi|270006131|gb|EFA02579.1| hypothetical protein TcasGA2_TC008297 [Tribolium castaneum] 749794019 XM_011152023.1 52 1.10589e-15 PREDICTED: Harpegnathos saltator transmembrane protein 184C (LOC105189732), transcript variant X4, mRNA -- -- -- -- Q3TPR7 699 4.7e-72 Transmembrane protein 184C OS=Mus musculus GN=Tmem184c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.13631 BF_2 39.00 0.72 2551 91080903 XP_973591.1 1592 4.1e-174 PREDICTED: protein lethal(2)denticleless [Tribolium castaneum]>gi|270005936|gb|EFA02384.1| hypothetical protein TcasGA2_TC008061 [Tribolium castaneum] -- -- -- -- -- K11790 DTL, CDT2, DCAF2 denticleless http://www.genome.jp/dbget-bin/www_bget?ko:K11790 Q24371 940 6.8e-100 Protein lethal(2)denticleless OS=Drosophila melanogaster GN=l(2)dtl PE=1 SV=2 PF00111//PF00400 2Fe-2S iron-sulfur cluster binding domain//WD domain, G-beta repeat GO:0006118 obsolete electron transport GO:0005515//GO:0009055//GO:0051536 protein binding//electron carrier activity//iron-sulfur cluster binding -- -- KOG0321 WD40 repeat-containing protein L2DTL Cluster-8309.13632 BF_2 4.00 0.57 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13639 BF_2 8.29 0.34 1315 642918959 XP_008191673.1 710 4.0e-72 PREDICTED: NEDD8 ultimate buster 1-like [Tribolium castaneum]>gi|270005608|gb|EFA02056.1| hypothetical protein TcasGA2_TC007685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5A7 223 4.9e-17 NEDD8 ultimate buster 1 OS=Homo sapiens GN=NUB1 PE=1 SV=2 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG2561 Adaptor protein NUB1, contains UBA domain Cluster-8309.13642 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13646 BF_2 22.50 2.49 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0006865//GO:0003333 amino acid transport//amino acid transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.13647 BF_2 20.00 2.14 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13648 BF_2 5.00 5.33 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13649 BF_2 32.00 3.85 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13651 BF_2 138.14 1.47 4205 91082901 XP_972219.1 678 6.6e-68 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- K13128 ZCCHC8 zinc finger CCHC domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13128 Q2PE14 512 4.8e-50 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.13652 BF_2 3.00 0.61 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13653 BF_2 22.97 0.55 2043 270008217 EFA04665.1 866 5.1e-90 cytochrome P450-like protein [Tribolium castaneum] 194753078 XM_001958810.1 37 2.48764e-07 Drosophila ananassae GF12357 (Dana\GF12357), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 O46051 638 5.7e-65 Probable cytochrome P450 4d14 OS=Drosophila melanogaster GN=Cyp4d14 PE=3 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.13654 BF_2 274.25 5.86 2245 91080515 XP_971732.1 865 7.3e-90 PREDICTED: galectin-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00214 372 4.4e-34 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.13656 BF_2 23.39 0.60 1931 642936688 XP_008198537.1 390 7.5e-35 PREDICTED: uncharacterized protein LOC655388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13659 BF_2 36.00 2.33 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13660 BF_2 4.41 0.33 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13661 BF_2 9.00 2.88 417 123389586 XP_001299746.1 294 2.2e-24 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121880660|gb|EAX86816.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q4UMH6 242 9.7e-20 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.13662 BF_2 5.00 1.16 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13664 BF_2 39.07 0.96 1981 478251617 ENN72078.1 175 6.6e-10 hypothetical protein YQE_11264, partial [Dendroctonus ponderosae]>gi|546674549|gb|ERL85905.1| hypothetical protein D910_03320 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13667 BF_2 46.02 2.73 993 91085713 XP_972970.1 1055 3.0e-112 PREDICTED: cyclin-H [Tribolium castaneum]>gi|270010021|gb|EFA06469.1| hypothetical protein TcasGA2_TC009354 [Tribolium castaneum] -- -- -- -- -- K06634 CCNH cyclin H http://www.genome.jp/dbget-bin/www_bget?ko:K06634 Q9R1A0 539 8.4e-54 Cyclin-H OS=Rattus norvegicus GN=Ccnh PE=2 SV=2 PF02984//PF00382//PF01857 Cyclin, C-terminal domain//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain GO:0000079//GO:0006355//GO:0051726 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated//regulation of cell cycle GO:0017025//GO:0019901 TBP-class protein binding//protein kinase binding GO:0005675//GO:0005634 holo TFIIH complex//nucleus KOG2496 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit Cluster-8309.13672 BF_2 25.00 0.97 1366 642921880 XP_008192928.1 713 1.9e-72 PREDICTED: uncharacterized protein LOC100141968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156//PF00115//PF02536 Protein of unknown function (DUF972)//Cytochrome C and Quinol oxidase polypeptide I//mTERF GO:0006260//GO:0006355//GO:0006118//GO:0015992//GO:0055114//GO:0009060//GO:0006123 DNA replication//regulation of transcription, DNA-templated//obsolete electron transport//proton transport//oxidation-reduction process//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen GO:0009055//GO:0005506//GO:0003690//GO:0020037//GO:0004129 electron carrier activity//iron ion binding//double-stranded DNA binding//heme binding//cytochrome-c oxidase activity GO:0005739//GO:0016021//GO:0045277 mitochondrion//integral component of membrane//respiratory chain complex IV -- -- Cluster-8309.13675 BF_2 293.85 8.62 1714 91083689 XP_966502.1 1090 4.5e-116 PREDICTED: hydroxysteroid dehydrogenase-like protein 1 [Tribolium castaneum]>gi|642924362|ref|XP_008194265.1| PREDICTED: hydroxysteroid dehydrogenase-like protein 1 [Tribolium castaneum]>gi|642924364|ref|XP_008194266.1| PREDICTED: hydroxysteroid dehydrogenase-like protein 1 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q3SXM5 617 1.3e-62 Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Homo sapiens GN=HSDL1 PE=1 SV=3 PF01370//PF00106//PF01356 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Alpha amylase inhibitor GO:0008152 metabolic process GO:0015066//GO:0050662//GO:0003824//GO:0016491 alpha-amylase inhibitor activity//coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.13684 BF_2 3.14 0.31 716 642924854 XP_008194067.1 572 2.2e-56 PREDICTED: LOW QUALITY PROTEIN: protein mahjong [Tribolium castaneum] -- -- -- -- -- K11789 VPRBP, DCAF1 HIV-1 Vpr-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11789 Q9W2F2 392 6.7e-37 Protein mahjong OS=Drosophila melanogaster GN=mahj PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1832 HIV-1 Vpr-binding protein Cluster-8309.13686 BF_2 75.14 4.49 988 91081409 XP_972874.1 765 1.3e-78 PREDICTED: lipase 1 [Tribolium castaneum]>gi|270005172|gb|EFA01620.1| hypothetical protein TcasGA2_TC007189 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 619 4.4e-63 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13688 BF_2 43.35 1.53 1469 642920590 XP_008192477.1 613 7.9e-61 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 496 1.2e-48 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.13691 BF_2 49.44 2.52 1108 91081409 XP_972874.1 765 1.4e-78 PREDICTED: lipase 1 [Tribolium castaneum]>gi|270005172|gb|EFA01620.1| hypothetical protein TcasGA2_TC007189 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 624 1.3e-63 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.13693 BF_2 4.65 1.22 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13698 BF_2 35.00 1.43 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13704 BF_2 54.00 0.63 3901 546673691 ERL85252.1 406 2.1e-36 hypothetical protein D910_02673 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06009//PF01544 Laminin Domain II//CorA-like Mg2+ transporter protein GO:0030001//GO:0007155//GO:0055085 metal ion transport//cell adhesion//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.13709 BF_2 42.87 0.98 2113 478257072 ENN77235.1 322 6.3e-27 hypothetical protein YQE_06065, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- F1R983 136 9.6e-07 DNA endonuclease RBBP8 OS=Danio rerio GN=rbbp8 PE=2 SV=1 PF08573//PF02050 DNA repair protein endonuclease SAE2/CtIP C-terminus//Flagellar FliJ protein GO:0000077//GO:0006308//GO:0006935//GO:0006281//GO:0071973 DNA damage checkpoint//DNA catabolic process//chemotaxis//DNA repair//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0000014 motor activity//single-stranded DNA endodeoxyribonuclease activity GO:0016020//GO:0009288 membrane//bacterial-type flagellum -- -- Cluster-8309.13714 BF_2 90.00 4.61 1103 91082171 XP_970910.1 848 3.3e-88 PREDICTED: N-terminal Xaa-Pro-Lys N-methyltransferase 1 [Tribolium castaneum]>gi|270007239|gb|EFA03687.1| hypothetical protein TcasGA2_TC013789 [Tribolium castaneum] -- -- -- -- -- K16219 NTMT1, METTL11A, NTM1 protein N-terminal methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K16219 B1H2P7 534 3.5e-53 N-terminal Xaa-Pro-Lys N-methyltransferase 1 OS=Xenopus tropicalis GN=ntmt1 PE=2 SV=1 PF08241//PF05175//PF05891//PF00891 Methyltransferase domain//Methyltransferase small domain//AdoMet dependent proline di-methyltransferase//O-methyltransferase GO:0032259//GO:0008152//GO:0006480 methylation//metabolic process//N-terminal protein amino acid methylation GO:0008171//GO:0008168 O-methyltransferase activity//methyltransferase activity -- -- KOG3178 Hydroxyindole-O-methyltransferase and related SAM-dependent methyltransferases Cluster-8309.13715 BF_2 101.71 2.53 1967 546674382 ERL85769.1 1622 1.1e-177 hypothetical protein D910_03184 [Dendroctonus ponderosae] -- -- -- -- -- K17609 NXN nucleoredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K17609 Q6DKJ4 530 1.8e-52 Nucleoredoxin OS=Homo sapiens GN=NXN PE=1 SV=2 PF00578//PF00832//PF08534//PF00085 AhpC/TSA family//Ribosomal L39 protein//Redoxin//Thioredoxin GO:0045454//GO:0042254//GO:0055114//GO:0006412 cell redox homeostasis//ribosome biogenesis//oxidation-reduction process//translation GO:0003735//GO:0016209//GO:0016491 structural constituent of ribosome//antioxidant activity//oxidoreductase activity GO:0005840//GO:0005622 ribosome//intracellular KOG2501 Thioredoxin, nucleoredoxin and related proteins Cluster-8309.13716 BF_2 6.29 0.51 804 91085541 XP_972533.1 320 4.1e-27 PREDICTED: nucleoredoxin [Tribolium castaneum]>gi|270008359|gb|EFA04807.1| hypothetical protein TcasGA2_TC014856 [Tribolium castaneum] -- -- -- -- -- K17609 NXN nucleoredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K17609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13718 BF_2 28.39 0.31 4075 642911057 XP_008200622.1 2105 2.2e-233 PREDICTED: uncharacterized protein LOC655172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SJE0 191 7.7e-13 GDNF family receptor alpha-like OS=Mus musculus GN=Gfral PE=2 SV=2 PF16093 Proteasome assembly chaperone 4 GO:0043248 proteasome assembly -- -- -- -- -- -- Cluster-8309.13723 BF_2 295.58 3.61 3716 642914904 XP_008190437.1 1291 4.8e-139 PREDICTED: aldehyde dehydrogenase 5, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T1L0 282 2.0e-23 Aldehyde dehydrogenase family 16 member A1 OS=Rattus norvegicus GN=Aldh16a1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.13730 BF_2 30.00 0.75 1955 642912516 XP_008200897.1 2171 2.3e-241 PREDICTED: slit homolog 1 protein [Tribolium castaneum] 749730939 XM_011145586.1 75 1.78748e-28 PREDICTED: Harpegnathos saltator slit homolog 1 protein (LOC105185782), mRNA -- -- -- -- P08953 384 1.6e-35 Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 PF13855//PF13676//PF01582 Leucine rich repeat//TIR domain//TIR domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.13731 BF_2 28.00 0.56 2375 270002906 EEZ99353.1 3532 0.0e+00 tollo [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70389 455 1.1e-43 Insulin-like growth factor-binding protein complex acid labile subunit OS=Mus musculus GN=Igfals PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13732 BF_2 1.00 1.59 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13741 BF_2 4.00 0.38 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13746 BF_2 202.19 7.89 1359 332375989 AEE63135.1 1240 1.4e-133 unknown [Dendroctonus ponderosae]>gi|478258650|gb|ENN78700.1| hypothetical protein YQE_04872, partial [Dendroctonus ponderosae] 645003560 XR_512750.1 92 4.371e-38 PREDICTED: Nasonia vitripennis kidney mitochondrial carrier protein 1 (LOC100120159), transcript variant X2, misc_RNA K15106 SLC25A14_30 solute carrier family 25 (mitochondrial carrier), member 14/30 http://www.genome.jp/dbget-bin/www_bget?ko:K15106 Q9CR58 796 1.8e-83 Kidney mitochondrial carrier protein 1 OS=Mus musculus GN=Slc25a30 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.13751 BF_2 188.20 7.08 1399 646719797 KDR21783.1 645 1.5e-64 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 596 2.9e-60 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF07352//PF00956 Bacteriophage Mu Gam like protein//Nucleosome assembly protein (NAP) GO:0006334//GO:0042262 nucleosome assembly//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.13752 BF_2 97.82 4.76 1147 646719797 KDR21783.1 645 1.2e-64 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 596 2.4e-60 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF00956//PF02990 Nucleosome assembly protein (NAP)//Endomembrane protein 70 GO:0006334 nucleosome assembly -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.13754 BF_2 4.00 0.56 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13755 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13760 BF_2 2.00 0.32 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13765 BF_2 15.72 0.88 1031 91090888 XP_973381.1 920 1.4e-96 PREDICTED: YEATS domain-containing protein 4 [Tribolium castaneum]>gi|270014003|gb|EFA10451.1| hypothetical protein TcasGA2_TC012697 [Tribolium castaneum] 571562276 XM_396159.3 137 3.17806e-63 PREDICTED: Apis mellifera YEATS domain-containing protein 4 (Gas41), transcript variant X2, mRNA K11341 YEATS4, GAS41, YAF9 YEATS domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11341 O95619 670 5.6e-69 YEATS domain-containing protein 4 OS=Homo sapiens GN=YEATS4 PE=1 SV=1 PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.13766 BF_2 105.55 1.88 2637 817082989 XP_012264082.1 209 1.0e-13 PREDICTED: homeobox protein PKNOX2-like isoform X1 [Athalia rosae]>gi|817082991|ref|XP_012264083.1| PREDICTED: homeobox protein PKNOX2-like isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q2HJ84 195 1.7e-13 Homeobox protein PKNOX1 OS=Bos taurus GN=PKNOX1 PE=2 SV=1 PF00096//PF00046//PF07776//PF05920//PF13465//PF13912//PF00412//PF04810 Zinc finger, C2H2 type//Homeobox domain//Zinc-finger associated domain (zf-AD)//Homeobox KN domain//Zinc-finger double domain//C2H2-type zinc finger//LIM domain//Sec23/Sec24 zinc finger GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.13767 BF_2 84.52 1.33 2943 283969671 ADB54565.1 209 1.1e-13 PREP homeodomain-like protein [Schmidtea mediterranea] -- -- -- -- -- -- -- -- -- Q2HJ84 195 1.9e-13 Homeobox protein PKNOX1 OS=Bos taurus GN=PKNOX1 PE=2 SV=1 PF05920//PF07776//PF00096//PF00046//PF13912//PF04810//PF00412//PF13465 Homeobox KN domain//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Homeobox domain//C2H2-type zinc finger//Sec23/Sec24 zinc finger//LIM domain//Zinc-finger double domain GO:0006886//GO:0006888//GO:0006355 intracellular protein transport//ER to Golgi vesicle-mediated transport//regulation of transcription, DNA-templated GO:0003677//GO:0046872//GO:0008270 DNA binding//metal ion binding//zinc ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.13769 BF_2 217.53 2.66 3706 189234638 XP_975412.2 1912 4.7e-211 PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913950|ref|XP_008201227.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913953|ref|XP_008201229.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|270001630|gb|EEZ98077.1| hypothetical protein TcasGA2_TC000484 [Tribolium castaneum] -- -- -- -- -- K06229 SUFU suppressor of fused http://www.genome.jp/dbget-bin/www_bget?ko:K06229 Q9Z0P7 971 2.5e-103 Suppressor of fused homolog OS=Mus musculus GN=Sufu PE=1 SV=1 PF12470 Suppressor of Fused Gli/Ci N terminal binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13770 BF_2 40.37 1.86 1194 91092542 XP_968010.1 770 4.0e-79 PREDICTED: nucleoporin Nup43 [Tribolium castaneum]>gi|270006621|gb|EFA03069.1| hypothetical protein TcasGA2_TC010925 [Tribolium castaneum] -- -- -- -- -- K14305 NUP43 nuclear pore complex protein Nup43 http://www.genome.jp/dbget-bin/www_bget?ko:K14305 Q8NFH3 368 6.8e-34 Nucleoporin Nup43 OS=Homo sapiens GN=NUP43 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13771 BF_2 94.97 1.14 3766 189234638 XP_975412.2 1924 1.9e-212 PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913950|ref|XP_008201227.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913953|ref|XP_008201229.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|270001630|gb|EEZ98077.1| hypothetical protein TcasGA2_TC000484 [Tribolium castaneum] -- -- -- -- -- K06229 SUFU suppressor of fused http://www.genome.jp/dbget-bin/www_bget?ko:K06229 Q9Z0P7 1269 7.1e-138 Suppressor of fused homolog OS=Mus musculus GN=Sufu PE=1 SV=1 PF12470 Suppressor of Fused Gli/Ci N terminal binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.13773 BF_2 13.19 0.82 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13775 BF_2 155.00 8.51 1049 642925222 XP_001811901.2 506 1.4e-48 PREDICTED: COMM domain-containing protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ76 217 1.9e-16 COMM domain-containing protein 3 OS=Bos taurus GN=COMMD3 PE=2 SV=1 PF05184//PF06350 Saposin-like type B, region 1//Hormone-sensitive lipase (HSL) N-terminus GO:0006629//GO:0008203//GO:0016042 lipid metabolic process//cholesterol metabolic process//lipid catabolic process GO:0016298 lipase activity -- -- -- -- Cluster-8309.13776 BF_2 144.00 4.43 1646 546681339 ERL91453.1 1660 3.5e-182 hypothetical protein D910_08783 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96CB9 521 1.7e-51 5-methylcytosine rRNA methyltransferase NSUN4 OS=Homo sapiens GN=NSUN4 PE=1 SV=2 PF01189//PF01728 16S rRNA methyltransferase RsmF//FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.13779 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13781 BF_2 17.00 0.76 1221 668447823 KFB37563.1 164 7.6e-09 hypothetical protein ZHAS_00004799 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.13782 BF_2 118.50 2.31 2432 189237885 XP_975345.2 2844 0.0e+00 PREDICTED: conserved oligomeric Golgi complex subunit 4 [Tribolium castaneum]>gi|270006703|gb|EFA03151.1| hypothetical protein TcasGA2_TC013064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95TN4 1685 2.7e-186 Conserved oligomeric Golgi complex subunit 4 OS=Drosophila melanogaster GN=CG7456 PE=1 SV=1 PF07393 Exocyst complex component Sec10 GO:0006887//GO:0048278 exocytosis//vesicle docking -- -- GO:0005737 cytoplasm KOG0412 Golgi transport complex COD1 protein Cluster-8309.13787 BF_2 44.00 1.98 1218 478255833 ENN76041.1 506 1.7e-48 hypothetical protein YQE_07414, partial [Dendroctonus ponderosae]>gi|546680472|gb|ERL90738.1| hypothetical protein D910_08085 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VKD7 179 5.7e-12 Mitochondrial cardiolipin hydrolase OS=Drosophila melanogaster GN=zuc PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1379 BF_2 5.00 0.34 898 744582533 XP_010984398.1 194 1.9e-12 PREDICTED: histone H3.1 [Camelus dromedarius] -- -- -- -- -- K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P90543 191 1.7e-13 Histone H3 OS=Euplotes crassus PE=3 SV=3 PF00125//PF02969 Core histone H2A/H2B/H3/H4//TATA box binding protein associated factor (TAF) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.13793 BF_2 4.00 0.46 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13801 BF_2 19.00 0.77 1317 642910706 XP_008200525.1 761 4.9e-78 PREDICTED: uncharacterized protein LOC103314950 [Tribolium castaneum]>gi|642910708|ref|XP_008200526.1| PREDICTED: uncharacterized protein LOC103314950 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13805 BF_2 72.09 1.11 3015 270001354 EEZ97801.1 3487 0.0e+00 hypothetical protein TcasGA2_TC000163 [Tribolium castaneum] 817183960 XM_012423831.1 511 0 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13811 BF_2 20.07 1.48 854 749732921 XP_011142956.1 305 2.4e-25 PREDICTED: uncharacterized protein LOC105185281 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13812 BF_2 85.93 7.89 743 478253284 ENN73653.1 347 2.8e-30 hypothetical protein YQE_09731, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13817 BF_2 38.08 0.66 2687 546683622 ERL93410.1 923 1.6e-96 hypothetical protein D910_10702 [Dendroctonus ponderosae] 676494731 XM_009068407.1 36 1.18085e-06 Lottia gigantea hypothetical protein mRNA K01057 PGLS, pgl, devB 6-phosphogluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01057 P85971 532 1.5e-52 6-phosphogluconolactonase OS=Rattus norvegicus GN=Pgls PE=1 SV=1 PF09771//PF01182 Transmembrane protein 188//Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase GO:0005975//GO:0035307 carbohydrate metabolic process//positive regulation of protein dephosphorylation -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.13822 BF_2 341.96 3.76 4090 91094617 XP_968941.1 495 1.1e-46 PREDICTED: NEDD4-binding protein 2 [Tribolium castaneum]>gi|270016434|gb|EFA12880.1| hypothetical protein TcasGA2_TC011558 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UW6 202 4.1e-14 NEDD4-binding protein 2 OS=Homo sapiens GN=N4BP2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2401 Predicted MutS-related protein involved in mismatch repair Cluster-8309.13827 BF_2 48.72 1.04 2239 478259929 ENN79731.1 1241 1.8e-133 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U2U7 606 3.2e-61 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF09243//PF12326//PF02285 Mitochondrial small ribosomal subunit Rsm22//N-glycosylation protein//Cytochrome oxidase c subunit VIII GO:0015992//GO:0034599//GO:0006412//GO:0006123 proton transport//cellular response to oxidative stress//translation//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277//GO:0005789 respiratory chain complex IV//endoplasmic reticulum membrane KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.13831 BF_2 15.00 0.65 1259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13835 BF_2 17.00 0.42 1979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13837 BF_2 5.53 0.35 957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13838 BF_2 111.00 4.59 1298 91078694 XP_971269.1 963 1.8e-101 PREDICTED: mitochondrial inner membrane protease ATP23 homolog [Tribolium castaneum]>gi|270003760|gb|EFA00208.1| hypothetical protein TcasGA2_TC003033 [Tribolium castaneum] -- -- -- -- -- K18156 ATP23, XRCC6BP1 mitochondrial inner membrane protease ATP23 http://www.genome.jp/dbget-bin/www_bget?ko:K18156 A4IGF3 406 2.9e-38 Mitochondrial inner membrane protease ATP23 homolog OS=Danio rerio GN=zgc:162885 PE=2 SV=1 PF09768 Peptidase M76 family -- -- GO:0004222 metalloendopeptidase activity -- -- KOG3314 Ku70-binding protein Cluster-8309.13840 BF_2 184.00 2.80 3039 332373326 AEE61804.1 1238 5.5e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14829 IPI3 pre-rRNA-processing protein IPI3 http://www.genome.jp/dbget-bin/www_bget?ko:K14829 Q68EI0 554 4.7e-55 WD repeat-containing protein 18 OS=Danio rerio GN=wdr18 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus KOG0646 WD40 repeat protein Cluster-8309.13848 BF_2 34.88 0.81 2093 91076754 XP_973519.1 844 1.8e-87 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG39 154 7.8e-09 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.1385 BF_2 2.00 0.85 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13850 BF_2 12.00 0.98 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13856 BF_2 71.56 7.66 678 91089477 XP_969208.1 279 2.0e-22 PREDICTED: zinc finger HIT domain-containing protein 3 [Tribolium castaneum]>gi|270012577|gb|EFA09025.1| hypothetical protein TcasGA2_TC006734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQK1 181 1.9e-12 Zinc finger HIT domain-containing protein 3 OS=Mus musculus GN=Znhit3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2857 Predicted MYND Zn-finger protein/hormone receptor interactor Cluster-8309.13857 BF_2 306.00 6.65 2213 91090592 XP_972768.1 1921 2.5e-212 PREDICTED: RNA polymerase I-specific transcription initiation factor RRN3 [Tribolium castaneum] -- -- -- -- -- K15216 RRN3, TIFIA RNA polymerase I-specific transcription initiation factor RRN3 http://www.genome.jp/dbget-bin/www_bget?ko:K15216 B2RS91 878 9.2e-93 RNA polymerase I-specific transcription initiation factor RRN3 OS=Mus musculus GN=Rrn3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2434 RNA polymerase I transcription factor Cluster-8309.13869 BF_2 33.26 1.25 1399 546684929 ERL94511.1 181 9.3e-11 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.13870 BF_2 20.07 0.45 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13874 BF_2 402.43 2.86 6173 642932046 XP_008196836.1 832 1.3e-85 PREDICTED: uncharacterized protein LOC103313971 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80VL1 172 1.9e-10 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF04277//PF15802 Oxaloacetate decarboxylase, gamma chain//DDB1- and CUL4-associated factor 17 GO:0006814//GO:0071436//GO:0006090//GO:0016567//GO:0006560//GO:0006525 sodium ion transport//sodium ion export//pyruvate metabolic process//protein ubiquitination//proline metabolic process//arginine metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.13876 BF_2 71.62 2.29 1597 817053121 XP_012260281.1 1815 3.6e-200 PREDICTED: exportin-7 isoform X1 [Athalia rosae] 683938964 XM_009099819.1 215 2.17295e-106 PREDICTED: Serinus canaria exportin 7 (XPO7), partial mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 1497 1.1e-164 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.13877 BF_2 33.39 0.63 2505 189235509 XP_969871.2 1824 5.1e-201 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 659 2.6e-67 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.13878 BF_2 3.00 0.44 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13882 BF_2 24.20 0.87 1457 642931096 XP_974337.3 538 3.9e-52 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09751 TMPRSS11B transmembrane protease, serine 11B http://www.genome.jp/dbget-bin/www_bget?ko:K09751 Q9VWU1 365 1.8e-33 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089//PF12937 Trypsin//F-box-like GO:0006508 proteolysis GO:0005515//GO:0004252 protein binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.13885 BF_2 4.00 0.36 753 817076166 XP_012260341.1 519 3.2e-50 PREDICTED: transcription factor BTF3 homolog 4 [Athalia rosae] 242002665 XM_002435931.1 119 2.32456e-53 Ixodes scapularis RNA polymerase II proteinral transcription factor BTF3, putative, mRNA K01527 EGD1, BTF3 nascent polypeptide-associated complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01527 Q6PC91 493 1.4e-48 Transcription factor BTF3 homolog 4 OS=Danio rerio GN=btf3l4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2240 RNA polymerase II general transcription factor BTF3 and related proteins Cluster-8309.13887 BF_2 44.95 1.80 1334 270013563 EFA10011.1 471 2.1e-44 hypothetical protein TcasGA2_TC012182 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7G4 310 4.0e-27 Protein FAM45A OS=Danio rerio GN=fam45a PE=2 SV=1 PF03495 Clostridial binary toxin B/anthrax toxin PA GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.13890 BF_2 20.00 0.35 2647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13891 BF_2 12.37 1.26 698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02386 Cation transport protein GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.13892 BF_2 70.00 0.99 3231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13894 BF_2 40.00 1.09 1827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05746 DALR anticodon binding domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0004814 ATP binding//arginine-tRNA ligase activity -- -- -- -- Cluster-8309.13896 BF_2 3.00 1.75 355 91081061 XP_975415.1 277 1.7e-22 PREDICTED: 40S ribosomal protein S2 [Tribolium castaneum]>gi|270005317|gb|EFA01765.1| hypothetical protein TcasGA2_TC007364 [Tribolium castaneum] 389624376 XM_003709794.1 187 1.64669e-91 Magnaporthe oryzae 70-15 30S ribosomal protein S5 (MGG_16248) mRNA, complete cds K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 O74892 301 1.2e-26 40S ribosomal protein S2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=rps2 PE=1 SV=1 PF00333 Ribosomal protein S5, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0015935//GO:0005840 small ribosomal subunit//ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-8309.13902 BF_2 30.90 0.49 2916 642934942 XP_008195881.1 782 4.0e-80 PREDICTED: RCC1 domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K07944 ARL3 ADP-ribosylation factor-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07944 Q8QHI3 589 3.9e-59 ADP-ribosylation factor-like protein 3 OS=Xenopus laevis GN=arl3 PE=2 SV=1 PF01926//PF08477//PF02421//PF00025//PF00004//PF00005//PF03785//PF00071//PF04670//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA)//ABC transporter//Peptidase family C25, C terminal ig-like domain//Ras family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007165//GO:0007264//GO:0015684//GO:0007186//GO:0006508 signal transduction//small GTPase mediated signal transduction//ferrous iron transport//G-protein coupled receptor signaling pathway//proteolysis GO:0003924//GO:0015093//GO:0005524//GO:0031683//GO:0008233//GO:0005525//GO:0004871//GO:0019001//GO:0016887 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//G-protein beta/gamma-subunit complex binding//peptidase activity//GTP binding//signal transducer activity//guanyl nucleotide binding//ATPase activity GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.13903 BF_2 133.10 3.25 2003 642934942 XP_008195881.1 782 2.7e-80 PREDICTED: RCC1 domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NED2 334 1.0e-29 RCC1 domain-containing protein 1 OS=Homo sapiens GN=RCCD1 PE=1 SV=1 PF03785 Peptidase family C25, C terminal ig-like domain GO:0006508 proteolysis GO:0008233 peptidase activity -- -- KOG1426 FOG: RCC1 domain Cluster-8309.13912 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13913 BF_2 4.00 2.93 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13919 BF_2 65.20 0.38 7466 91095249 XP_971558.1 840 1.9e-86 PREDICTED: 60S ribosome subunit biogenesis protein NIP7 homolog [Tribolium castaneum]>gi|270016870|gb|EFA13316.1| hypothetical protein TcasGA2_TC006900 [Tribolium castaneum] 752871555 XM_011254679.1 92 2.45104e-37 PREDICTED: Camponotus floridanus 60S ribosome subunit biogenesis protein NIP7 homolog (LOC105249313), mRNA K07565 NIP7 60S ribosome subunit biogenesis protein NIP7 http://www.genome.jp/dbget-bin/www_bget?ko:K07565 Q503P2 684 9.7e-70 60S ribosome subunit biogenesis protein NIP7 homolog OS=Danio rerio GN=nip7 PE=2 SV=1 PF03002//PF08686//PF03973//PF00515//PF13414//PF13176//PF13181//PF01472//PF04369 Somatostatin/Cortistatin family//PLAC (protease and lacunin) domain//Triabin//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//PUA domain//Lactococcin-like family GO:0042255//GO:0007165//GO:0042742//GO:0030682 ribosome assembly//signal transduction//defense response to bacterium//evasion or tolerance of host defense response GO:0005179//GO:0005515//GO:0003723//GO:0008233 hormone activity//protein binding//RNA binding//peptidase activity GO:0005634//GO:0005576 nucleus//extracellular region KOG3492 Ribosome biogenesis protein NIP7 Cluster-8309.13920 BF_2 32.43 0.47 3164 546683292 ERL93124.1 324 5.5e-27 hypothetical protein D910_10425, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P42704 163 1.1e-09 Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens GN=LRPPRC PE=1 SV=3 PF04369//PF13181//PF13414//PF13176//PF03002//PF08686//PF00515//PF03973 Lactococcin-like family//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Somatostatin/Cortistatin family//PLAC (protease and lacunin) domain//Tetratricopeptide repeat//Triabin GO:0030682//GO:0042742//GO:0007165 evasion or tolerance of host defense response//defense response to bacterium//signal transduction GO:0005515//GO:0008233//GO:0005179 protein binding//peptidase activity//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.13929 BF_2 22.31 0.58 1898 189240952 XP_971597.2 1295 8.5e-140 PREDICTED: methionine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q9VFL5 931 5.6e-99 Methionine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-met PE=2 SV=2 PF08264//PF09334//PF00133 Anticodon-binding domain of tRNA//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG0436 Methionyl-tRNA synthetase Cluster-8309.13932 BF_2 5.00 0.74 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13933 BF_2 9.00 0.31 1510 821114442 XP_012381239.1 200 6.3e-13 PREDICTED: synaptonemal complex protein 2 isoform X1 [Dasypus novemcinctus] -- -- -- -- -- -- -- -- -- Q9BX26 184 1.9e-12 Synaptonemal complex protein 2 OS=Homo sapiens GN=SYCP2 PE=2 SV=2 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.13938 BF_2 68.47 0.48 6204 322785072 EFZ11815.1 718 2.2e-72 hypothetical protein SINV_08288, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08188//PF03121 Spermatozal protamine family//Herpesviridae UL52/UL70 DNA primase GO:0006351//GO:0035092//GO:0006269//GO:0006260 transcription, DNA-templated//sperm chromatin condensation//DNA replication, synthesis of RNA primer//DNA replication GO:0003896//GO:0003677 DNA primase activity//DNA binding GO:0005657//GO:0005730//GO:0000228 replication fork//nucleolus//nuclear chromosome -- -- Cluster-8309.13941 BF_2 8.65 0.98 655 546680624 ERL90862.1 229 1.2e-16 hypothetical protein D910_08207 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.13947 BF_2 6.00 0.33 1048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13949 BF_2 43.20 1.47 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06337 DUSP domain GO:0016579//GO:0006508 protein deubiquitination//proteolysis GO:0004843 ubiquitin-specific protease activity -- -- -- -- Cluster-8309.13950 BF_2 7.00 2.03 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13953 BF_2 69.33 2.26 1572 642919030 XP_008191704.1 1146 1.3e-122 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 194893660 XM_001977880.1 36 6.84849e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF10458//PF12920 Valyl tRNA synthetase tRNA binding arm//TcdA/TcdB pore forming domain GO:0009098//GO:0009097//GO:0009405//GO:0006438//GO:0009099 leucine biosynthetic process//isoleucine biosynthetic process//pathogenesis//valyl-tRNA aminoacylation//valine biosynthetic process GO:0005524//GO:0000166//GO:0004832 ATP binding//nucleotide binding//valine-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.13954 BF_2 108.42 3.88 1455 642919030 XP_008191704.1 876 2.5e-91 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 194893660 XM_001977880.1 36 6.32717e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF10458//PF12920 Valyl tRNA synthetase tRNA binding arm//TcdA/TcdB pore forming domain GO:0009099//GO:0009405//GO:0006438//GO:0009097//GO:0009098 valine biosynthetic process//pathogenesis//valyl-tRNA aminoacylation//isoleucine biosynthetic process//leucine biosynthetic process GO:0004832//GO:0000166//GO:0005524 valine-tRNA ligase activity//nucleotide binding//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.13957 BF_2 3.00 0.48 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13958 BF_2 229.87 2.15 4768 91086801 XP_973474.1 2037 1.9e-225 PREDICTED: transmembrane protein 8A [Tribolium castaneum]>gi|642929011|ref|XP_008195653.1| PREDICTED: transmembrane protein 8A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QLK4 427 3.9e-40 Transmembrane protein 8B OS=Bos taurus GN=TMEM8B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.13961 BF_2 154.15 3.40 2183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane -- -- Cluster-8309.1397 BF_2 2.00 0.31 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13970 BF_2 16.18 1.14 879 642928748 XP_008199766.1 199 4.8e-13 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.13978 BF_2 4.00 0.91 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13979 BF_2 274.12 3.83 3282 642927677 XP_008196502.1 557 5.5e-54 PREDICTED: protein quiver [Tribolium castaneum] 759079745 XM_011351395.1 136 3.71912e-62 PREDICTED: Cerapachys biroi protein quiver (LOC105286442), transcript variant X2, mRNA -- -- -- -- B3NSF6 523 2.0e-51 Protein quiver OS=Drosophila erecta GN=qvr PE=3 SV=1 PF17064//PF01064 Sleepless protein//Activin types I and II receptor domain GO:0030431//GO:1903818//GO:0032222//GO:0016310//GO:0009069//GO:0007178 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic//phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.13981 BF_2 138.53 1.94 3276 270009903 EFA06351.1 534 2.6e-51 hypothetical protein TcasGA2_TC009226 [Tribolium castaneum] 759079745 XM_011351395.1 136 3.71224e-62 PREDICTED: Cerapachys biroi protein quiver (LOC105286442), transcript variant X2, mRNA -- -- -- -- B4HNI3 517 9.8e-51 Protein quiver OS=Drosophila sechellia GN=qvr PE=3 SV=2 PF17064//PF01064 Sleepless protein//Activin types I and II receptor domain GO:0007178//GO:0016310//GO:0009069//GO:1903818//GO:0030431//GO:0032222 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic GO:0034235//GO:0004675 GPI anchor binding//transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.13987 BF_2 12.55 0.43 1502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.13999 BF_2 7.00 0.78 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14000 BF_2 24.98 3.18 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14001 BF_2 1.00 0.35 407 241813583 XP_002416512.1 232 3.3e-17 hypothetical protein IscW_ISCW015113 [Ixodes scapularis]>gi|215510976|gb|EEC20429.1| hypothetical protein IscW_ISCW015113 [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14002 BF_2 63.72 3.55 1038 642910499 XP_008200240.1 1139 5.7e-122 PREDICTED: G protein alpha i subunit [Tribolium castaneum]>gi|270014387|gb|EFA10835.1| hypothetical protein TcasGA2_TC001612 [Tribolium castaneum] 676443682 XM_009051945.1 104 7.07619e-45 Lottia gigantea hypothetical protein partial mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P20353 986 1.3e-105 G protein alpha i subunit OS=Drosophila melanogaster GN=Galphai PE=1 SV=2 PF08477//PF01580//PF00025//PF04670//PF00503 Ras of Complex, Roc, domain of DAPkinase//FtsK/SpoIIIE family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005524//GO:0003677//GO:0031683//GO:0005525//GO:0000166//GO:0004871//GO:0019001 GTPase activity//ATP binding//DNA binding//G-protein beta/gamma-subunit complex binding//GTP binding//nucleotide binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.1401 BF_2 2.00 0.62 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14011 BF_2 75.17 0.46 7185 642935862 XP_008198202.1 2012 2.3e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 8.78747e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 3.7e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF13176//PF13414//PF13371//PF00515//PF13374//PF00638//PF02064//PF13181 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RanBP1 domain//MAS20 protein import receptor//Tetratricopeptide repeat GO:0046907//GO:0006886//GO:0006605 intracellular transport//intracellular protein transport//protein targeting GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.14012 BF_2 23.00 0.72 1624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.14013 BF_2 8.93 1.39 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14015 BF_2 13.00 0.33 1916 270015859 EFA12307.1 146 1.5e-06 hypothetical protein TcasGA2_TC016102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14017 BF_2 32.00 0.95 1702 758375864 AJO70184.1 1476 7.8e-161 sodium-potassium ATPase beta [Cherax cainii] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 P25169 761 2.6e-79 Sodium/potassium-transporting ATPase subunit beta OS=Artemia franciscana PE=2 SV=1 PF02140//PF00287 Galactose binding lectin domain//Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport GO:0030246 carbohydrate binding GO:0005890 sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.14019 BF_2 8.14 0.95 647 642939494 XP_008190865.1 421 6.4e-39 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0043167//GO:0003824 ion binding//catalytic activity -- -- -- -- Cluster-8309.14022 BF_2 133.17 2.24 2778 642915531 XP_008190654.1 1985 1.2e-219 PREDICTED: 1-acylglycerophosphocholine O-acyltransferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13510 LPCAT1_2 lysophosphatidylcholine acyltransferase / lyso-PAF acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13510 Q0KHU5 1061 6.9e-114 1-acylglycerophosphocholine O-acyltransferase 1 OS=Drosophila melanogaster GN=CG32699 PE=2 SV=1 PF13499//PF13833//PF00036//PF13405//PF01553 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Acyltransferase GO:0008152 metabolic process GO:0016746//GO:0005509 transferase activity, transferring acyl groups//calcium ion binding -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.14026 BF_2 20.56 0.44 2226 189241122 XP_001812931.1 721 3.6e-73 PREDICTED: protein saal1 [Tribolium castaneum]>gi|270013331|gb|EFA09779.1| hypothetical protein TcasGA2_TC011921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q803M5 199 5.0e-14 Protein saal1 OS=Danio rerio GN=saal1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14032 BF_2 6.00 0.48 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14035 BF_2 7.00 0.97 589 641672832 XP_008186080.1 158 1.8e-08 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q14119 137 2.0e-07 Vascular endothelial zinc finger 1 OS=Homo sapiens GN=VEZF1 PE=1 SV=2 PF00096//PF13465//PF02892//PF13912//PF00643 Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//B-box zinc finger -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.14052 BF_2 45.00 2.84 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14053 BF_2 45.00 1.51 1533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05770 Inositol 1, 3, 4-trisphosphate 5/6-kinase GO:0032957 inositol trisphosphate metabolic process GO:0000287//GO:0047325//GO:0052725//GO:0052726//GO:0005524 magnesium ion binding//inositol tetrakisphosphate 1-kinase activity//inositol-1,3,4-trisphosphate 6-kinase activity//inositol-1,3,4-trisphosphate 5-kinase activity//ATP binding GO:0005622 intracellular -- -- Cluster-8309.14054 BF_2 56.00 2.22 1341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14056 BF_2 15.17 0.48 1616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14058 BF_2 408.10 13.98 1508 283046838 NP_001164362.1 1764 2.8e-194 pleiohomeotic [Tribolium castaneum]>gi|270009286|gb|EFA05734.1| pleiohomeotic [Tribolium castaneum] 462309609 APGK01047630.1 135 6.07194e-62 Dendroctonus ponderosae Seq01047640, whole genome shotgun sequence K09201 YY transcription factor YY http://www.genome.jp/dbget-bin/www_bget?ko:K09201 P25490 903 7.9e-96 Transcriptional repressor protein YY1 OS=Homo sapiens GN=YY1 PE=1 SV=2 PF16622//PF13465//PF02176//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.14061 BF_2 3.00 0.93 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14063 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0003723//GO:0008270 RNA binding//zinc ion binding -- -- -- -- Cluster-8309.14065 BF_2 121.69 1.44 3820 642914114 XP_008201549.1 3028 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X2 [Tribolium castaneum] 642914119 XM_008203330.1 557 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q68DX3 206 1.3e-14 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14066 BF_2 13.92 0.64 1192 642922922 XP_971943.2 737 2.7e-75 PREDICTED: coiled-coil domain-containing protein 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T312 546 1.5e-54 Coiled-coil domain-containing protein 25 OS=Danio rerio GN=ccdc25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3272 Predicted coiled-coil protein Cluster-8309.14072 BF_2 12.00 0.54 1213 478257049 ENN77213.1 199 6.6e-13 hypothetical protein YQE_06350, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14076 BF_2 7.00 0.54 829 828217980 XP_012560822.1 309 8.0e-26 PREDICTED: uncharacterized protein LOC105846528 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04545//PF00196//PF08281//PF08220//PF01498//PF01316//PF01418//PF01527//PF13404 Sigma-70, region 4//Bacterial regulatory proteins, luxR family//Sigma-70, region 4//DeoR-like helix-turn-helix domain//Transposase//Arginine repressor, DNA binding domain//Helix-turn-helix domain, rpiR family//Transposase//AsnC-type helix-turn-helix domain GO:0015074//GO:0006352//GO:0006355//GO:0006313//GO:0006525 DNA integration//DNA-templated transcription, initiation//regulation of transcription, DNA-templated//transposition, DNA-mediated//arginine metabolic process GO:0004803//GO:0003700//GO:0016987//GO:0043565//GO:0003677 transposase activity//transcription factor activity, sequence-specific DNA binding//sigma factor activity//sequence-specific DNA binding//DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex -- -- Cluster-8309.14077 BF_2 6.00 0.44 860 357610760 EHJ67138.1 386 9.7e-35 putative transposase-like protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- Q04202 193 9.6e-14 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14081 BF_2 104.95 3.71 1471 270007349 EFA03797.1 818 1.3e-84 hypothetical protein TcasGA2_TC013909 [Tribolium castaneum] -- -- -- -- -- K19383 TGIF1 homeobox protein TGIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K19383 Q15583 274 6.6e-23 Homeobox protein TGIF1 OS=Homo sapiens GN=TGIF1 PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.14082 BF_2 52.05 1.33 1923 270007349 EFA03797.1 818 1.8e-84 hypothetical protein TcasGA2_TC013909 [Tribolium castaneum] -- -- -- -- -- K19383 TGIF1 homeobox protein TGIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K19383 Q15583 274 8.7e-23 Homeobox protein TGIF1 OS=Homo sapiens GN=TGIF1 PE=1 SV=3 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.14086 BF_2 110.60 2.29 2311 189236498 XP_975203.2 2096 1.4e-232 PREDICTED: protein lin-9 homolog isoform X1 [Tribolium castaneum] 817204910 XM_012422927.1 153 9.25022e-72 PREDICTED: Orussus abietinus protein lin-9 homolog (LOC105698571), transcript variant X4, mRNA -- -- -- -- Q8C735 1086 7.3e-117 Protein lin-9 homolog OS=Mus musculus GN=Lin9 PE=2 SV=2 PF06584//PF05460 DIRP//Origin recognition complex subunit 6 (ORC6) GO:0007049//GO:0006351//GO:0006260 cell cycle//transcription, DNA-templated//DNA replication GO:0003677 DNA binding GO:0017053//GO:0005664 transcriptional repressor complex//nuclear origin of replication recognition complex -- -- Cluster-8309.14087 BF_2 34.18 0.60 2673 4559259 AAD22957.1 3576 0.0e+00 voltage-sensitive sodium channel [Leptinotarsa decemlineata] 4559258 AF114489.1 1154 0 AF114489 Leptinotarsa decemlineata voltage-sensitive sodium channel mRNA, partial cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 2602 1.4e-292 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF06512//PF06016//PF00520 Sodium ion transport-associated//Reovirus core-spike protein lambda-2 (L2)//Ion transport protein GO:0006811//GO:0009451//GO:0006370//GO:0006814//GO:0055085 ion transport//RNA modification//7-methylguanosine mRNA capping//sodium ion transport//transmembrane transport GO:0005216//GO:0004484//GO:0004482//GO:0005248//GO:0005524 ion channel activity//mRNA guanylyltransferase activity//mRNA (guanine-N7-)-methyltransferase activity//voltage-gated sodium channel activity//ATP binding GO:0016020//GO:0001518//GO:0019028 membrane//voltage-gated sodium channel complex//viral capsid -- -- Cluster-8309.1409 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14092 BF_2 14.00 0.94 911 642915927 XP_008190814.1 470 1.9e-44 PREDICTED: centrosomal protein of 63 kDa-like [Tribolium castaneum]>gi|270003750|gb|EFA00198.1| hypothetical protein TcasGA2_TC003023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07716//PF02334//PF06005//PF04977//PF14304 Basic region leucine zipper//Replication terminator protein//Protein of unknown function (DUF904)//Septum formation initiator//Transcription termination and cleavage factor C-terminal GO:0006355//GO:0007049//GO:0043093//GO:0000917//GO:0006274//GO:0031124 regulation of transcription, DNA-templated//cell cycle//FtsZ-dependent cytokinesis//barrier septum assembly//DNA replication termination//mRNA 3'-end processing GO:0043565//GO:0003700//GO:0003677 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.14093 BF_2 169.00 5.08 1678 332374738 AEE62510.1 1044 9.5e-111 unknown [Dendroctonus ponderosae]>gi|478255086|gb|ENN75316.1| hypothetical protein YQE_08093, partial [Dendroctonus ponderosae]>gi|546678678|gb|ERL89246.1| hypothetical protein D910_06619 [Dendroctonus ponderosae] -- -- -- -- -- K14568 EMG1, NEP1 rRNA small subunit pseudouridine methyltransferase Nep1 http://www.genome.jp/dbget-bin/www_bget?ko:K14568 Q9W4J5 809 7.0e-85 Ribosomal RNA small subunit methyltransferase NEP1 OS=Drosophila melanogaster GN=CG3527 PE=3 SV=2 PF03587 EMG1/NEP1 methyltransferase -- -- GO:0008168 methyltransferase activity -- -- KOG3073 Protein required for 18S rRNA maturation and 40S ribosome biogenesis Cluster-8309.14102 BF_2 16.94 1.12 918 642930142 XP_008196269.1 986 2.8e-104 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X3 [Tribolium castaneum] 189164165 EU545256.1 262 9.17914e-133 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 753 1.2e-78 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.14106 BF_2 4.00 0.35 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14107 BF_2 2.00 0.32 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14113 BF_2 80.76 1.11 3334 270010054 EFA06502.1 1245 9.3e-134 hypothetical protein TcasGA2_TC009401 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 736 4.0e-76 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF09668//PF00098 Aspartyl protease//Zinc knuckle GO:0006508 proteolysis GO:0008270//GO:0003676//GO:0004190 zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.14118 BF_2 7.88 0.35 1236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1412 BF_2 1.00 0.63 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14125 BF_2 5.05 0.35 895 478254865 ENN75101.1 182 4.6e-11 hypothetical protein YQE_08414, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q19821 131 1.5e-06 Rhomboid-related protein 1 OS=Caenorhabditis elegans GN=rom-1 PE=3 SV=2 PF01694//PF06072//PF03839 Rhomboid family//Alphaherpesvirus tegument protein US9//Translocation protein Sec62 GO:0015031 protein transport GO:0008565//GO:0004252 protein transporter activity//serine-type endopeptidase activity GO:0016021//GO:0019033 integral component of membrane//viral tegument KOG2289 Rhomboid family proteins Cluster-8309.14127 BF_2 285.00 6.83 2034 91080603 XP_974067.1 757 2.2e-77 PREDICTED: RING finger protein 141 [Tribolium castaneum]>gi|270005817|gb|EFA02265.1| hypothetical protein TcasGA2_TC007929 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZM74 367 1.5e-33 RING finger protein 141 OS=Gallus gallus GN=RNF141 PE=2 SV=1 PF13639//PF00097//PF12678//PF17123//PF03854//PF12861//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//P-11 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0003723//GO:0004842//GO:0005515//GO:0008270//GO:0043169//GO:0046872 RNA binding//ubiquitin-protein transferase activity//protein binding//zinc ion binding//cation binding//metal ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.14132 BF_2 9.00 0.72 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02981 Restriction endonuclease FokI, recognition domain GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.14133 BF_2 27.08 0.58 2228 642921407 XP_973880.2 776 1.5e-79 PREDICTED: glycerate kinase [Tribolium castaneum] -- -- -- -- -- K15788 GLYCTK glycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K15788 Q0VGK3 509 5.7e-50 Glycerate kinase OS=Rattus norvegicus GN=Glyctk PE=2 SV=1 PF12409 P5-type ATPase cation transporter GO:0006812 cation transport GO:0016887 ATPase activity GO:0016021 integral component of membrane KOG3935 Predicted glycerate kinase Cluster-8309.14134 BF_2 48.79 1.42 1720 642921407 XP_973880.2 1031 3.1e-109 PREDICTED: glycerate kinase [Tribolium castaneum] -- -- -- -- -- K15788 GLYCTK glycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K15788 Q0VGK3 676 1.9e-69 Glycerate kinase OS=Rattus norvegicus GN=Glyctk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3935 Predicted glycerate kinase Cluster-8309.14138 BF_2 39.00 3.28 785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14141 BF_2 74.14 2.52 1516 546673103 ERL84772.1 991 1.2e-104 hypothetical protein D910_02197 [Dendroctonus ponderosae] -- -- -- -- -- K02328 POLD2 DNA polymerase delta subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02328 P49005 606 2.2e-61 DNA polymerase delta subunit 2 OS=Homo sapiens GN=POLD2 PE=1 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG2732 DNA polymerase delta, regulatory subunit 55 Cluster-8309.14144 BF_2 8.15 0.33 1321 646717332 KDR20226.1 527 6.7e-51 hypothetical protein L798_05535, partial [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q4R4C7 461 1.2e-44 Zinc finger protein 14 OS=Macaca fascicularis GN=ZNF14 PE=2 SV=1 PF05191//PF16622//PF01428//PF01844//PF13912//PF02892//PF00412//PF04810//PF07975//PF02701//PF13465//PF00628//PF00096 Adenylate kinase, active site lid//zinc-finger C2H2-type//AN1-like Zinc finger//HNH endonuclease//C2H2-type zinc finger//BED zinc finger//LIM domain//Sec23/Sec24 zinc finger//TFIIH C1-like domain//Dof domain, zinc finger//Zinc-finger double domain//PHD-finger//Zinc finger, C2H2 type GO:0006886//GO:0006281//GO:0006888//GO:0006144//GO:0046034//GO:0006355 intracellular protein transport//DNA repair//ER to Golgi vesicle-mediated transport//purine nucleobase metabolic process//ATP metabolic process//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0004519//GO:0046872//GO:0004017//GO:0003676//GO:0008270 protein binding//DNA binding//endonuclease activity//metal ion binding//adenylate kinase activity//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.14150 BF_2 36.70 1.02 1791 91082813 XP_968677.1 1347 7.4e-146 PREDICTED: transmembrane protein 43 homolog [Tribolium castaneum]>gi|270007099|gb|EFA03547.1| hypothetical protein TcasGA2_TC013551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSB9 736 2.2e-76 Transmembrane protein 43 homolog OS=Drosophila melanogaster GN=CG8111 PE=2 SV=1 PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.14154 BF_2 66.21 2.82 1269 332374692 AEE62487.1 739 1.7e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8QZW3 337 2.8e-30 Protein FAM151A OS=Mus musculus GN=Fam151a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14155 BF_2 10.13 0.32 1620 332374692 AEE62487.1 742 9.6e-76 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8QZW3 348 1.9e-31 Protein FAM151A OS=Mus musculus GN=Fam151a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14158 BF_2 132.70 8.77 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14160 BF_2 43.71 0.88 2359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14161 BF_2 2.00 0.40 494 795017073 XP_011858722.1 139 2.4e-06 PREDICTED: uncharacterized protein LOC105556247 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14163 BF_2 30.00 2.40 810 157092995 ABV22152.1 667 2.4e-67 cyclophilin [Perkinsus chesapeaki] 21886602 AJ311666.1 307 7.77767e-158 Betula verrucosa mRNA for peptidylprolyl isomerase (cyclophilin), ppiase gene (CyP) K03767 PPIA peptidyl-prolyl cis-trans isomerase A (cyclophilin A) http://www.genome.jp/dbget-bin/www_bget?ko:K03767 Q39613 761 1.2e-79 Peptidyl-prolyl cis-trans isomerase OS=Catharanthus roseus GN=PCKR1 PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.14169 BF_2 33.00 4.45 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14170 BF_2 82.48 1.37 2805 766938860 XP_011501956.1 794 1.6e-81 PREDICTED: uncharacterized protein LOC105365477 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505//PF00884 Clostridium enterotoxin//Sulfatase GO:0009405//GO:0008152 pathogenesis//metabolic process GO:0008484 sulfuric ester hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.14172 BF_2 31.35 0.61 2444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14173 BF_2 705.00 8.19 3888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01654 Cytochrome bd terminal oxidase subunit I -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.14174 BF_2 6.00 0.36 994 296490452 DAA32565.1 971 1.6e-102 TPA: ribosomal protein L15-like [Bos taurus] 358356393 NM_002948.3 994 0 Homo sapiens ribosomal protein L15 (RPL15), transcript variant 1, mRNA K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 Q5NVE0 971 6.7e-104 60S ribosomal protein L15 OS=Pongo abelii GN=RPL15 PE=2 SV=3 PF00906//PF00827 Hepatitis core antigen//Ribosomal L15 GO:0006412//GO:0042254//GO:0009405 translation//ribosome biogenesis//pathogenesis GO:0005198//GO:0003735 structural molecule activity//structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.14175 BF_2 2.00 0.36 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14176 BF_2 147.00 5.73 1361 270004308 EFA00756.1 716 8.3e-73 hypothetical protein TcasGA2_TC003641 [Tribolium castaneum] -- -- -- -- -- K15280 SLC35C2 solute carrier family 35, member C2 http://www.genome.jp/dbget-bin/www_bget?ko:K15280 Q9VM17 431 3.8e-41 SOSS complex subunit B homolog OS=Drosophila melanogaster GN=CG5181 PE=2 SV=1 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG3416 Predicted nucleic acid binding protein Cluster-8309.14177 BF_2 1.78 0.34 506 607349253 EZA46573.1 160 9.2e-09 hypothetical protein X777_00019, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14183 BF_2 63.58 1.80 1763 157954027 NP_001103243.1 1445 3.2e-157 ligand-gated ion channel subunit precursor [Tribolium castaneum]>gi|156447627|gb|ABU63606.1| ligand-gated ion channel subunit [Tribolium castaneum]>gi|270002893|gb|EEZ99340.1| ligand-gated ion channel subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61603 505 1.3e-49 Glycine receptor subunit alpha-4 OS=Mus musculus GN=Glra4 PE=2 SV=3 PF02931//PF02932//PF02212//PF08121 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region//Dynamin GTPase effector domain//Waglerin family GO:0006811//GO:0007165//GO:0006810//GO:0007268 ion transport//signal transduction//transport//synaptic transmission GO:0005230//GO:0005525//GO:0030550//GO:0003924 extracellular ligand-gated ion channel activity//GTP binding//acetylcholine receptor inhibitor activity//GTPase activity GO:0016020//GO:0005576//GO:0030054//GO:0045211//GO:0005886//GO:0016021 membrane//extracellular region//cell junction//postsynaptic membrane//plasma membrane//integral component of membrane -- -- Cluster-8309.14190 BF_2 150.95 1.37 4905 642918266 XP_008191438.1 6923 0.0e+00 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] 755988817 XM_011313677.1 459 0 PREDICTED: Fopius arisanus dual oxidase (LOC105271872), mRNA K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 6223 0.0e+00 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 PF13499//PF13833//PF13405//PF12763//PF08030//PF08022//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand//Ferric reductase NAD binding domain//FAD-binding domain//EF hand//EF hand GO:0055114 oxidation-reduction process GO:0005509//GO:0005515//GO:0016491 calcium ion binding//protein binding//oxidoreductase activity -- -- KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.14196 BF_2 54.90 0.52 4702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02505//PF00424//PF05699//PF11837 Methyl-coenzyme M reductase operon protein D//REV protein (anti-repression trans-activator protein)//hAT family C-terminal dimerisation region//Domain of unknown function (DUF3357) GO:0006355//GO:0015948//GO:0005982//GO:0005985//GO:0006012 regulation of transcription, DNA-templated//methanogenesis//starch metabolic process//sucrose metabolic process//galactose metabolic process GO:0003700//GO:0004564//GO:0046983//GO:0004575 transcription factor activity, sequence-specific DNA binding//beta-fructofuranosidase activity//protein dimerization activity//sucrose alpha-glucosidase activity GO:0017177//GO:0005667//GO:0042025 glucosidase II complex//transcription factor complex//host cell nucleus -- -- Cluster-8309.14198 BF_2 13.68 1.15 785 642933067 XP_971928.3 718 2.8e-73 PREDICTED: uncharacterized serine/threonine-protein kinase SgK494 [Tribolium castaneum] -- -- -- -- -- K17529 SGK494 uncharacterized serine/threonine-protein kinase SgK494 http://www.genome.jp/dbget-bin/www_bget?ko:K17529 Q8MYQ1 370 2.6e-34 Putative serine/threonine-protein kinase F31E3.2 OS=Caenorhabditis elegans GN=F31E3.2 PE=3 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.14199 BF_2 41.57 0.95 2126 91082233 XP_972708.1 1193 6.4e-128 PREDICTED: 2',5'-phosphodiesterase 12 [Tribolium castaneum]>gi|270007451|gb|EFA03899.1| hypothetical protein TcasGA2_TC014029 [Tribolium castaneum] 752886955 XM_011263028.1 45 9.2513e-12 PREDICTED: Camponotus floridanus 2',5'-phosphodiesterase 12-like (LOC105254385), partial mRNA K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q6AXQ5 772 1.7e-80 2',5'-phosphodiesterase 12 OS=Rattus norvegicus GN=Pde12 PE=2 SV=1 PF01304 Gas vesicles protein GVPc repeated domain GO:0031412 gas vesicle organization -- -- GO:0031411 gas vesicle KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.1420 BF_2 3.00 0.34 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.14201 BF_2 10.00 0.57 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14203 BF_2 35.78 0.99 1799 642916330 XP_008190976.1 693 5.1e-70 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|270004190|gb|EFA00638.1| hypothetical protein TcasGA2_TC003514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25386 149 2.5e-08 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF02183//PF10473 Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006355 regulation of transcription, DNA-templated GO:0008134//GO:0045502//GO:0003700//GO:0042803//GO:0043565 transcription factor binding//dynein binding//transcription factor activity, sequence-specific DNA binding//protein homodimerization activity//sequence-specific DNA binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.14211 BF_2 202.90 4.36 2234 270007535 EFA03983.1 1973 2.4e-218 hypothetical protein TcasGA2_TC014132 [Tribolium castaneum] 823397955 XM_004395671.2 39 2.10599e-08 PREDICTED: Odobenus rosmarus divergens solute carrier family 6 (neurotransmitter transporter), member 6 (SLC6A6), mRNA K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 P48067 1203 1.9e-130 Sodium- and chloride-dependent glycine transporter 1 OS=Homo sapiens GN=SLC6A9 PE=2 SV=3 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.14220 BF_2 14.00 0.33 2048 270008742 EFA05190.1 2137 2.1e-237 hypothetical protein TcasGA2_TC015323 [Tribolium castaneum] 734607656 XM_010732733.1 174 1.73376e-83 PREDICTED: Larimichthys crocea serine/threonine-protein kinase BRSK2 (LOC104920464), mRNA K08796 BRSK BR serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08796 Q19469 1523 1.4e-167 Serine/threonine kinase SAD-1 OS=Caenorhabditis elegans GN=sad-1 PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0588 Serine/threonine protein kinase Cluster-8309.14222 BF_2 4.00 0.77 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14223 BF_2 31.82 1.71 1067 642931641 XP_008196668.1 727 3.5e-74 PREDICTED: tetratricopeptide repeat protein 26 [Tribolium castaneum]>gi|270012187|gb|EFA08635.1| hypothetical protein TcasGA2_TC006298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4III8 566 6.7e-57 Intraflagellar transport protein 56 OS=Xenopus tropicalis GN=ttc26 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3785 Uncharacterized conserved protein Cluster-8309.14224 BF_2 65.18 2.12 1574 642931641 XP_008196668.1 2169 3.2e-241 PREDICTED: tetratricopeptide repeat protein 26 [Tribolium castaneum]>gi|270012187|gb|EFA08635.1| hypothetical protein TcasGA2_TC006298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U2N8 1719 2.0e-190 Intraflagellar transport protein 56 OS=Rattus norvegicus GN=Ttc26 PE=2 SV=1 PF13176//PF13414//PF13174//PF13371//PF13181//PF00515 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG3785 Uncharacterized conserved protein Cluster-8309.14226 BF_2 371.00 21.01 1026 478263683 ENN81989.1 580 3.7e-57 hypothetical protein YQE_01700, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5E9E8 222 5.0e-17 Protein YIPF5 OS=Bos taurus GN=YIPF5 PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG3103 Rab GTPase interacting factor, Golgi membrane protein Cluster-8309.14232 BF_2 10.49 0.59 1031 642933131 XP_008197270.1 796 3.3e-82 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 9.21934e-34 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 379 3.1e-35 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14236 BF_2 15.00 0.32 2277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.14238 BF_2 119.00 10.57 758 478258213 ENN78342.1 476 3.1e-45 hypothetical protein YQE_05144, partial [Dendroctonus ponderosae]>gi|546677009|gb|ERL87925.1| hypothetical protein D910_05313, partial [Dendroctonus ponderosae] -- -- -- -- -- K10745 RNASEH2C ribonuclease H2 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K10745 Q8TDP1 128 2.9e-06 Ribonuclease H2 subunit C OS=Homo sapiens GN=RNASEH2C PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14241 BF_2 54.00 1.11 2325 642926758 XP_008195001.1 938 2.6e-98 PREDICTED: gastrula zinc finger protein XlCGF52.1-like [Tribolium castaneum]>gi|270008400|gb|EFA04848.1| hypothetical protein TcasGA2_TC014900 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB30 549 1.4e-54 Zinc finger protein 585B OS=Pongo abelii GN=ZNF585B PE=2 SV=1 PF00096//PF13465//PF07776//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.14244 BF_2 10.00 0.99 709 671758370 AII97595.1 791 8.7e-82 BLTX199 [Nephila pilipes] -- -- -- -- -- K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 Q90Z10 686 5.4e-71 60S ribosomal protein L13 OS=Danio rerio GN=rpl13 PE=2 SV=3 PF01294 Ribosomal protein L13e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3295 60S Ribosomal protein L13 Cluster-8309.14248 BF_2 20.74 0.54 1884 748995278 AJE75661.1 1243 9.0e-134 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 923 4.7e-98 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.14251 BF_2 14.68 0.36 2009 641659246 XP_008181021.1 371 1.2e-32 PREDICTED: uncharacterized protein LOC103308774 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08093 Magi 5 toxic peptide family GO:0006810//GO:0009405 transport//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.14253 BF_2 31.76 0.64 2360 642928954 XP_008195631.1 1105 1.1e-117 PREDICTED: checkpoint protein HUS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 5.1e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF04005//PF02747 Hus1-like protein//Proliferating cell nuclear antigen, C-terminal domain GO:0006281//GO:0006275//GO:0000077 DNA repair//regulation of DNA replication//DNA damage checkpoint GO:0003677 DNA binding GO:0030896 checkpoint clamp complex KOG3999 Checkpoint 9-1-1 complex, HUS1 component Cluster-8309.14254 BF_2 163.59 3.83 2074 189239303 XP_971702.2 729 4.0e-74 PREDICTED: transmembrane protein 222 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 4.5e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF04005 Hus1-like protein GO:0006281//GO:0000077 DNA repair//DNA damage checkpoint -- -- GO:0030896 checkpoint clamp complex KOG3150 Uncharacterized conserved protein Cluster-8309.14255 BF_2 57.12 1.13 2409 642928954 XP_008195631.1 866 6.0e-90 PREDICTED: checkpoint protein HUS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 5.2e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF02747//PF04005 Proliferating cell nuclear antigen, C-terminal domain//Hus1-like protein GO:0006281//GO:0006275//GO:0000077 DNA repair//regulation of DNA replication//DNA damage checkpoint GO:0003677 DNA binding GO:0030896 checkpoint clamp complex KOG3999 Checkpoint 9-1-1 complex, HUS1 component Cluster-8309.1426 BF_2 3.00 0.46 559 795020088 XP_011859803.1 379 4.1e-34 PREDICTED: uncharacterized protein LOC105557226 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06273 Plant specific eukaryotic initiation factor 4B GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.14263 BF_2 29.85 0.85 1748 546675135 ERL86379.1 691 8.5e-70 hypothetical protein D910_03787, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N2G6 463 9.6e-45 Zinc finger CCHC domain-containing protein 24 OS=Homo sapiens GN=ZCCHC24 PE=1 SV=1 PF07562 Nine Cysteines Domain of family 3 GPCR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.14265 BF_2 147.00 3.83 1891 478250264 ENN70764.1 921 2.0e-96 hypothetical protein YQE_12552, partial [Dendroctonus ponderosae]>gi|546685959|gb|ERL95373.1| hypothetical protein D910_12637 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SYC1 244 2.6e-19 Clavesin-2 OS=Homo sapiens GN=CLVS2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14266 BF_2 16.89 0.56 1555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14268 BF_2 3.00 0.39 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14271 BF_2 2.00 0.82 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14274 BF_2 40.94 0.54 3464 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.6e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14276 BF_2 40.39 0.63 2986 642929093 XP_008195688.1 588 1.3e-57 PREDICTED: uncharacterized protein LOC103313644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05372//PF00598 Delta lysin family//Influenza Matrix protein (M1) GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005198//GO:0003723 structural molecule activity//RNA binding GO:0005576 extracellular region -- -- Cluster-8309.14278 BF_2 28.79 0.33 3973 871211803 XP_012946119.1 440 2.5e-40 PREDICTED: collagen alpha-1(I) chain-like [Aplysia californica] 170039347 XM_001847447.1 45 1.74132e-11 Culex quinquefasciatus collagen alpha 1(XVIII) chain, mRNA K08135 COL15A collagen, type XV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08135 P02453 359 2.5e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF10660//PF06482 Iron-containing outer mitochondrial membrane protein N-terminus//Collagenase NC10 and Endostatin GO:0007155 cell adhesion GO:0005198//GO:0051537 structural molecule activity//2 iron, 2 sulfur cluster binding GO:0031012//GO:0043231 extracellular matrix//intracellular membrane-bounded organelle -- -- Cluster-8309.14290 BF_2 76.40 0.70 4848 157694508 NP_001099012.1 2039 1.2e-225 Sid-1-related A precursor [Tribolium castaneum]>gi|156447787|gb|ABU63672.1| Sid-1-related A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AXF6 1036 9.6e-111 SID1 transmembrane family member 1 OS=Mus musculus GN=Sidt1 PE=2 SV=1 PF01733//PF13965//PF00507 Nucleoside transporter//dsRNA-gated channel SID-1//NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0015931//GO:0015858//GO:0006120//GO:0006810//GO:0006814//GO:0006744//GO:0055114//GO:0015992//GO:0033227 nucleobase-containing compound transport//nucleoside transport//mitochondrial electron transport, NADH to ubiquinone//transport//sodium ion transport//ubiquinone biosynthetic process//oxidation-reduction process//proton transport//dsRNA transport GO:0051033//GO:0005337//GO:0008137 RNA transmembrane transporter activity//nucleoside transmembrane transporter activity//NADH dehydrogenase (ubiquinone) activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.14291 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14294 BF_2 118.82 0.89 5903 157694508 NP_001099012.1 2039 1.4e-225 Sid-1-related A precursor [Tribolium castaneum]>gi|156447787|gb|ABU63672.1| Sid-1-related A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AXF6 1036 1.2e-110 SID1 transmembrane family member 1 OS=Mus musculus GN=Sidt1 PE=2 SV=1 PF13965//PF01733 dsRNA-gated channel SID-1//Nucleoside transporter GO:0015858//GO:0015931//GO:0033227//GO:0006810 nucleoside transport//nucleobase-containing compound transport//dsRNA transport//transport GO:0051033//GO:0005337 RNA transmembrane transporter activity//nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.143 BF_2 1.00 0.52 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14306 BF_2 7.39 0.36 1148 675373661 KFM66563.1 238 1.9e-17 Mid1-interacting protein 1-B, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q8AWD1 133 1.2e-06 Mid1-interacting protein 1-like OS=Danio rerio GN=mid1ip1l PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14308 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14309 BF_2 2.00 0.93 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1431 BF_2 6.00 0.34 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14312 BF_2 1.00 0.47 373 391346058 XP_003747297.1 354 2.2e-31 PREDICTED: innexin inx2-like [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q9XYN1 258 1.2e-21 Innexin inx2 OS=Schistocerca americana GN=inx2 PE=1 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.14314 BF_2 50.94 0.32 7040 642936341 XP_008198402.1 1821 3.2e-200 PREDICTED: adenylate kinase 9-like [Tribolium castaneum]>gi|270013134|gb|EFA09582.1| hypothetical protein TcasGA2_TC011699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TCS8 405 2.1e-37 Adenylate kinase 9 OS=Homo sapiens GN=AK9 PE=1 SV=2 PF00004//PF02224//PF00910 ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//RNA helicase GO:0006206//GO:0006139 pyrimidine nucleobase metabolic process//nucleobase-containing compound metabolic process GO:0004127//GO:0005524//GO:0003723//GO:0003724 cytidylate kinase activity//ATP binding//RNA binding//RNA helicase activity -- -- -- -- Cluster-8309.14317 BF_2 11.00 0.32 1727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05185 PRMT5 arginine-N-methyltransferase GO:0006479 protein methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.14321 BF_2 73.46 2.35 1593 642930251 XP_971223.2 984 8.2e-104 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 132 2.1e-06 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14322 BF_2 27.56 0.47 2735 576249490 AHH29251.1 2457 2.2e-274 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 1932 6.8e-215 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF00209//PF01384 Sodium:neurotransmitter symporter family//Phosphate transporter family GO:0006817//GO:0006812//GO:0006836 phosphate ion transport//cation transport//neurotransmitter transport GO:0005328//GO:0005315 neurotransmitter:sodium symporter activity//inorganic phosphate transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.14323 BF_2 5.00 0.49 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11857 Domain of unknown function (DUF3377) -- -- GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.14324 BF_2 4.00 0.33 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14325 BF_2 299.00 7.28 2005 768441096 XP_011562253.1 2001 1.2e-221 PREDICTED: AP-1 complex subunit mu-1 [Plutella xylostella] 807016054 XM_004518056.2 330 3.23361e-170 PREDICTED: Ceratitis capitata AP-1 complex subunit mu-1 (LOC101462016), mRNA K12393 AP1M AP-1 complex subunit mu http://www.genome.jp/dbget-bin/www_bget?ko:K12393 Q2KJ81 1811 5.4e-201 AP-1 complex subunit mu-1 OS=Bos taurus GN=AP1M1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0937 Adaptor complexes medium subunit family Cluster-8309.14331 BF_2 371.00 9.50 1920 478252326 ENN72752.1 1159 5.0e-124 hypothetical protein YQE_10557, partial [Dendroctonus ponderosae] -- -- -- -- -- K13165 SFRS12 splicing factor, arginine/serine-rich 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13165 O01159 466 4.7e-45 Probable splicing factor, arginine/serine-rich 7 OS=Caenorhabditis elegans GN=rsp-7 PE=3 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4676 Splicing factor, arginine/serine-rich Cluster-8309.14333 BF_2 38.00 7.03 513 328899579 AEB54641.1 570 2.7e-56 ribosomal protein L32 [Procambarus clarkii] -- -- -- -- -- K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q962T1 490 2.1e-48 60S ribosomal protein L32 OS=Spodoptera frugiperda GN=RpL32 PE=2 SV=1 PF01655 Ribosomal protein L32 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0878 60S ribosomal protein L32 Cluster-8309.14335 BF_2 38.00 0.74 2446 642918152 XP_008191389.1 1039 5.3e-110 PREDICTED: uncharacterized protein LOC103312472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13851 Growth-arrest specific micro-tubule binding GO:0048870 cell motility -- -- GO:0031514 motile cilium -- -- Cluster-8309.1434 BF_2 2.00 1.11 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14341 BF_2 41.40 0.49 3839 478263448 ENN81809.1 1913 3.7e-211 hypothetical protein YQE_01814, partial [Dendroctonus ponderosae]>gi|478263929|gb|ENN82095.1| hypothetical protein YQE_01527, partial [Dendroctonus ponderosae] 817188109 XM_012433187.1 139 9.36541e-64 PREDICTED: Orussus abietinus tubulin alpha chain-like (LOC105704177), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q7Z3E2 921 1.6e-97 Coiled-coil domain-containing protein 186 OS=Homo sapiens GN=CCDC186 PE=1 SV=2 PF13014 KH domain -- -- GO:0003723 RNA binding -- -- KOG1376 Alpha tubulin Cluster-8309.14347 BF_2 4.00 1.15 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14349 BF_2 36.00 1.76 1145 91087377 XP_975644.1 366 2.7e-32 PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum]>gi|642929867|ref|XP_008196006.1| PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum] -- -- -- -- -- K02219 CKS1 cyclin-dependent kinase regulatory subunit CKS1 http://www.genome.jp/dbget-bin/www_bget?ko:K02219 Q24152 323 1.1e-28 Cyclin-dependent kinases regulatory subunit OS=Drosophila melanogaster GN=Cks30A PE=3 SV=1 PF01111 Cyclin-dependent kinase regulatory subunit GO:0045859//GO:0007049 regulation of protein kinase activity//cell cycle GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG3484 Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins Cluster-8309.14350 BF_2 13.00 1.15 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14351 BF_2 14.00 0.97 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14352 BF_2 23.00 0.58 1951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14356 BF_2 433.26 3.28 5815 642915956 XP_008190826.1 3245 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 642915955 XM_008192604.1 625 0 PREDICTED: Tribolium castaneum protein kinase C, brain isozyme-like (LOC656250), mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 2723 2.8e-306 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF00168//PF00433//PF07714//PF07649//PF00628//PF00069//PF09472//PF00130 C2 domain//Protein kinase C terminal domain//Protein tyrosine kinase//C1-like domain//PHD-finger//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556//GO:0015948//GO:0009069//GO:0006468//GO:0046656//GO:0016310 oxidation-reduction process//intracellular signal transduction//methanogenesis//serine family amino acid metabolic process//protein phosphorylation//folic acid biosynthetic process//phosphorylation GO:0047134//GO:0004672//GO:0004674//GO:0005524//GO:0030269//GO:0005515 protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity//protein binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.14357 BF_2 22.79 0.58 1943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14358 BF_2 15.61 0.52 1544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14361 BF_2 275.00 18.41 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14366 BF_2 7.00 1.13 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14367 BF_2 5.00 0.58 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14368 BF_2 49.00 3.71 840 83939666 ABC48600.1 1268 5.1e-137 ribosomal protein L8 [Litopenaeus vannamei] 83939665 DQ316258.1 348 1.30481e-180 Litopenaeus vannamei ribosomal protein L8 mRNA, complete cds K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q95V39 1130 2.1e-122 60S ribosomal protein L8 OS=Spodoptera frugiperda GN=RpL8 PE=2 SV=1 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2309 60s ribosomal protein L2/L8 Cluster-8309.14369 BF_2 3.00 0.34 653 91092636 XP_968782.1 302 4.1e-25 PREDICTED: neurogenic protein big brain [Tribolium castaneum]>gi|270014847|gb|EFA11295.1| hypothetical protein TcasGA2_TC010832 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 P23645 275 2.3e-23 Neurogenic protein big brain OS=Drosophila melanogaster GN=bib PE=1 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.14370 BF_2 7.28 0.38 1090 478250805 ENN71297.1 251 5.6e-19 hypothetical protein YQE_12222, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P47947 198 3.2e-14 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF07988 LMSTEN motif GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.14371 BF_2 150.00 8.06 1066 91094099 XP_967118.1 890 4.4e-93 PREDICTED: N-alpha-acetyltransferase 40 [Tribolium castaneum]>gi|270010877|gb|EFA07325.1| hypothetical protein TcasGA2_TC015921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q568K5 523 6.4e-52 N-alpha-acetyltransferase 40 OS=Danio rerio GN=naa40 PE=2 SV=1 PF00583//PF13508//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG2488 Acetyltransferase (GNAT) domain-containing protein Cluster-8309.14375 BF_2 189.00 2.50 3446 642939976 XP_968254.2 241 2.5e-17 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270015788|gb|EFA12236.1| hypothetical protein TcasGA2_TC006924 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14377 BF_2 52.45 1.11 2270 642919931 XP_974732.3 1610 3.0e-176 PREDICTED: tetratricopeptide repeat protein 5-like [Tribolium castaneum]>gi|270005358|gb|EFA01806.1| hypothetical protein TcasGA2_TC007407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BK48 883 2.5e-93 Tetratricopeptide repeat protein 5 OS=Rattus norvegicus GN=Ttc5 PE=2 SV=1 PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14379 BF_2 1.00 9.01 236 2098753 AAC47523.1 294 1.2e-24 alpha-2-tubulin [Gecarcinus lateralis] 2098752 U92646.1 148 4.99463e-70 GLU92646 Gecarcinus lateralis alpha-2-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q94572 265 1.2e-22 Tubulin alpha-3 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.14380 BF_2 9.71 0.31 1584 546679463 ERL89927.1 660 3.0e-66 hypothetical protein D910_07286 [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 O95425 416 2.4e-39 Supervillin OS=Homo sapiens GN=SVIL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14381 BF_2 52.45 1.24 2053 735997411 NP_001290187.1 1240 2.2e-133 neuromedin-U receptor 2-like [Tribolium castaneum]>gi|189241567|ref|XP_968501.2| PREDICTED: neuromedin-U receptor 2-like [Tribolium castaneum]>gi|728893173|gb|AIZ00520.1| pyrokinin 1 receptor C [Tribolium castaneum] 749791816 XM_011150823.1 125 3.01311e-56 PREDICTED: Harpegnathos saltator neuromedin-U receptor 2-like (LOC105189016), transcript variant X3, mRNA K05052 NMUR1 neuromedin U receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05052 Q9GZQ4 528 3.3e-52 Neuromedin-U receptor 2 OS=Homo sapiens GN=NMUR2 PE=1 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.14383 BF_2 23.12 0.54 2082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03600 Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.14384 BF_2 5.34 0.40 846 642937921 XP_008199131.1 851 1.1e-88 PREDICTED: synapsin, partial [Tribolium castaneum] 642937920 XM_008200909.1 235 8.61238e-118 PREDICTED: Tribolium castaneum synapsin (LOC659883), partial mRNA -- -- -- -- Q24546 409 8.4e-39 Synapsin OS=Drosophila melanogaster GN=Syn PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14386 BF_2 215.00 18.86 764 642920339 XP_008192304.1 529 2.3e-51 PREDICTED: dnaJ-like protein 60 [Tribolium castaneum] -- -- -- -- -- K09536 DNAJC16 DnaJ homolog subfamily C member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K09536 P92029 222 3.7e-17 DnaJ-like protein 60 OS=Drosophila melanogaster GN=DnaJ-60 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.14389 BF_2 184.56 3.93 2250 478252437 ENN72860.1 1477 7.9e-161 hypothetical protein YQE_10509, partial [Dendroctonus ponderosae]>gi|546673468|gb|ERL85066.1| hypothetical protein D910_02489 [Dendroctonus ponderosae] -- -- -- -- -- K01639 E4.1.3.3, nanA, NPL N-acetylneuraminate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01639 Q66H59 334 1.1e-29 N-acetylneuraminate lyase OS=Rattus norvegicus GN=Npl PE=2 SV=1 PF00701 Dihydrodipicolinate synthetase family GO:0008152 metabolic process GO:0016829 lyase activity -- -- -- -- Cluster-8309.14392 BF_2 3.28 0.31 733 478259737 ENN79581.1 458 3.7e-43 hypothetical protein YQE_04043, partial [Dendroctonus ponderosae] 241998377 XM_002433787.1 41 5.17666e-10 Ixodes scapularis fucosyltransferase, putative, mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 352 3.0e-32 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14394 BF_2 47.61 2.22 1185 642934528 XP_008197700.1 858 2.5e-89 PREDICTED: platelet-derived growth factor receptor alpha isoform X3 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 427 9.7e-41 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14395 BF_2 79.72 2.24 1776 642934524 XP_008197698.1 361 1.6e-31 PREDICTED: uncharacterized protein LOC100141936 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 212 1.2e-15 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14396 BF_2 28.30 0.83 1719 642934530 XP_008197701.1 366 4.0e-32 PREDICTED: fibroblast growth factor receptor 4 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 212 1.2e-15 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.14399 BF_2 100.69 10.78 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14407 BF_2 26.87 0.69 1911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14408 BF_2 15.00 5.11 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1441 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14411 BF_2 9.00 1.78 499 546674048 ERL85536.1 134 9.3e-06 hypothetical protein D910_02955, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14414 BF_2 222.00 4.11 2547 270010170 EFA06618.1 643 4.6e-64 hypothetical protein TcasGA2_TC009536 [Tribolium castaneum] -- -- -- -- -- K11343 MRGBP MRG-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11343 Q9NV56 222 1.2e-16 MRG/MORF4L-binding protein OS=Homo sapiens GN=MRGBP PE=1 SV=1 PF07904//PF02724//PF02535 Chromatin modification-related protein EAF7//CDC45-like protein//ZIP Zinc transporter GO:0006355//GO:0055085//GO:0030001//GO:0006270 regulation of transcription, DNA-templated//transmembrane transport//metal ion transport//DNA replication initiation GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005634//GO:0043189 membrane//nucleus//H4/H2A histone acetyltransferase complex -- -- Cluster-8309.14415 BF_2 17.70 0.51 1745 91090662 XP_974317.1 1180 1.7e-126 PREDICTED: ubiquitin-like domain-containing CTD phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K17618 UBLCP1 ubiquitin-like domain-containing CTD phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17618 Q6DI37 884 1.5e-93 Ubiquitin-like domain-containing CTD phosphatase 1 OS=Danio rerio GN=ublcp1 PE=2 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14420 BF_2 27.23 0.73 1839 646717882 KDR20562.1 432 9.6e-40 Protein BTG1 [Zootermopsis nevadensis] 338224388 HM217837.1 575 0 Scylla paramamosain b-cell translocation protein-like mRNA, partial sequence K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P53348 327 5.9e-29 Protein BTG1 OS=Bos taurus GN=BTG1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14421 BF_2 18.77 0.50 1859 646717882 KDR20562.1 432 9.7e-40 Protein BTG1 [Zootermopsis nevadensis] 338224388 HM217837.1 575 0 Scylla paramamosain b-cell translocation protein-like mRNA, partial sequence K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P53348 327 6.0e-29 Protein BTG1 OS=Bos taurus GN=BTG1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14423 BF_2 1.00 0.46 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14424 BF_2 68.87 1.84 1849 662215751 XP_008481774.1 587 1.0e-57 PREDICTED: uncharacterized protein LOC103518485 [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q8I7P9 363 4.0e-33 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.14427 BF_2 65.00 4.04 961 642916726 XP_008192366.1 538 2.6e-52 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14430 BF_2 1.00 7.77 240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00032 Cytochrome b(C-terminal)/b6/petD GO:0006118 obsolete electron transport GO:0009055//GO:0016491 electron carrier activity//oxidoreductase activity GO:0016020 membrane -- -- Cluster-8309.14431 BF_2 46.80 2.17 1190 227018577 YP_002808494.1 936 2.3e-98 cytochrome b [Scylla tranquebarica]>gi|225697832|gb|ACO07201.1| cytochrome b [Scylla tranquebarica] 225697849 FJ827761.1 461 0 Scylla paramamosain mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 B0FWD7 914 3.3e-97 Cytochrome b OS=Aedes aegypti GN=mt:Cyt-b PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4663 Cytochrome b Cluster-8309.14433 BF_2 15.10 0.39 1893 189239809 XP_970870.2 437 2.6e-40 PREDICTED: transmembrane protease serine 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14434 BF_2 19.56 0.44 2144 642935122 XP_008197897.1 1889 1.3e-208 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08999 508 7.1e-50 Latent-transforming growth factor beta-binding protein 2 OS=Mus musculus GN=Ltbp2 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.14437 BF_2 11.00 0.90 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14440 BF_2 22.00 1.15 1088 642926052 XP_970129.2 646 8.7e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 218 1.5e-16 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14442 BF_2 3.00 0.45 568 189238516 XP_971527.2 239 7.1e-18 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270009070|gb|EFA05518.1| hypothetical protein TcasGA2_TC015705 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14445 BF_2 29.19 0.43 3130 91088947 XP_973771.1 2180 3.3e-242 PREDICTED: exocyst complex component 3 [Tribolium castaneum]>gi|270012371|gb|EFA08819.1| hypothetical protein TcasGA2_TC006514 [Tribolium castaneum] -- -- -- -- -- K06110 EXOC3, SEC6L1 exocyst complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06110 Q9V8K2 1357 3.7e-148 Exocyst complex component 3 OS=Drosophila melanogaster GN=sec6 PE=2 SV=2 PF06046//PF03283 Exocyst complex component Sec6//Pectinacetylesterase GO:0006887 exocytosis GO:0016787 hydrolase activity GO:0000145 exocyst KOG2286 Exocyst complex subunit SEC6 Cluster-8309.14446 BF_2 6.00 0.45 839 642938019 XP_008199173.1 251 4.3e-19 PREDICTED: protein bride of sevenless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14448 BF_2 18.27 0.36 2399 478255263 ENN75492.1 1233 1.7e-132 hypothetical protein YQE_08041, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24738 366 2.3e-33 Protein bride of sevenless OS=Drosophila virilis GN=boss PE=3 SV=1 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.14453 BF_2 38.17 0.60 2940 167234210 NP_001107807.1 1900 9.2e-210 maxillopedia [Tribolium castaneum]>gi|270002809|gb|EEZ99256.1| proboscipedia [Tribolium castaneum] 347972356 XM_001688909.2 72 1.25745e-26 Anopheles gambiae str. PEST AGAP004648-PA (AgaP_AGAP004648) mRNA, complete cds K09302 HOX_2 homeobox protein HoxA/B2 http://www.genome.jp/dbget-bin/www_bget?ko:K09302 P31264 547 2.9e-54 Homeotic protein proboscipedia OS=Drosophila melanogaster GN=pb PE=2 SV=2 PF00507//PF07904//PF00046 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3//Chromatin modification-related protein EAF7//Homeobox domain GO:0006744//GO:0006355//GO:0006814//GO:0015992//GO:0055114//GO:0006120 ubiquinone biosynthetic process//regulation of transcription, DNA-templated//sodium ion transport//proton transport//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003677 NADH dehydrogenase (ubiquinone) activity//DNA binding GO:0005634//GO:0043189 nucleus//H4/H2A histone acetyltransferase complex -- -- Cluster-8309.14454 BF_2 18.11 0.36 2367 91091470 XP_973218.1 572 7.2e-56 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 264 1.5e-21 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF05648 Peroxisomal biogenesis factor 11 (PEX11) GO:0016559 peroxisome fission -- -- GO:0005779 integral component of peroxisomal membrane -- -- Cluster-8309.14457 BF_2 143.00 1.59 4054 91089455 XP_976192.1 448 3.0e-41 PREDICTED: uncharacterized protein LOC656455 [Tribolium castaneum]>gi|270012567|gb|EFA09015.1| hypothetical protein TcasGA2_TC006723 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14464 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14465 BF_2 9.00 0.44 1141 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10729 Cell division activator CedA GO:0051301 cell division GO:0003677 DNA binding -- -- -- -- Cluster-8309.14485 BF_2 61.00 7.90 610 478254917 ENN75151.1 175 2.0e-10 hypothetical protein YQE_08264, partial [Dendroctonus ponderosae]>gi|546673845|gb|ERL85377.1| hypothetical protein D910_02797 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06221 Putative zinc finger motif, C2HC5-type GO:0006355 regulation of transcription, DNA-templated GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.14486 BF_2 11.00 0.40 1435 260784978 XP_002587540.1 1518 8.9e-166 hypothetical protein BRAFLDRAFT_282735 [Branchiostoma floridae]>gi|229272689|gb|EEN43551.1| hypothetical protein BRAFLDRAFT_282735 [Branchiostoma floridae] 655892251 XM_008250561.1 123 2.70406e-55 PREDICTED: Oryctolagus cuniculus 4-hydroxyphenylpyruvate dioxygenase (HPD), mRNA K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 Q6TGZ5 1417 1.9e-155 4-hydroxyphenylpyruvate dioxygenase OS=Danio rerio GN=hpd PE=2 SV=1 PF00487 Fatty acid desaturase GO:0006558//GO:0009072//GO:0006629//GO:0006570//GO:0055114 L-phenylalanine metabolic process//aromatic amino acid family metabolic process//lipid metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0046872//GO:0003868 metal ion binding//4-hydroxyphenylpyruvate dioxygenase activity -- -- KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.14488 BF_2 189.30 7.49 1344 332375084 AEE62683.1 674 6.1e-68 unknown [Dendroctonus ponderosae]>gi|478257085|gb|ENN77248.1| hypothetical protein YQE_06078, partial [Dendroctonus ponderosae]>gi|546683376|gb|ERL93198.1| hypothetical protein D910_10495 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PBF7 425 1.9e-40 ER membrane protein complex subunit 4 OS=Xenopus tropicalis GN=emc4 PE=2 SV=1 PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope KOG3318 Predicted membrane protein Cluster-8309.14490 BF_2 0.93 1.33 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14494 BF_2 13.00 0.67 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14495 BF_2 6.00 0.39 930 389611307 BAM19265.1 709 3.7e-72 peritrophin A [Papilio polytes] 195567826 XM_002107424.1 46 1.10254e-12 Drosophila simulans GD17481 (Dsim\GD17481), mRNA -- -- -- -- Q9W5U2 126 6.1e-06 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.14499 BF_2 21.00 2.52 636 311739209 ADQ01809.1 550 6.9e-54 opsin protein [Uca pugilator] 311739208 HM765425.1 264 4.83228e-134 Celuca pugilator opsin protein (Rh1) mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 512 7.3e-51 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.14505 BF_2 3.01 0.36 641 642936524 XP_008198472.1 330 2.3e-28 PREDICTED: transmembrane GTPase Marf [Tribolium castaneum]>gi|642936526|ref|XP_970147.2| PREDICTED: transmembrane GTPase Marf [Tribolium castaneum] -- -- -- -- -- K06030 MFN mitofusin http://www.genome.jp/dbget-bin/www_bget?ko:K06030 Q80U63 253 7.9e-21 Mitofusin-2 OS=Mus musculus GN=Mfn2 PE=1 SV=3 PF04548//PF05049//PF01926 AIG1 family//Interferon-inducible GTPase (IIGP)//50S ribosome-binding GTPase -- -- GO:0005525 GTP binding GO:0016020 membrane KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis Cluster-8309.14508 BF_2 38.90 0.55 3238 91088739 XP_975289.1 1117 6.3e-119 PREDICTED: serine protease 33 [Tribolium castaneum]>gi|270012788|gb|EFA09236.1| serine protease P74 [Tribolium castaneum] -- -- -- -- -- K09631 HGFAC hepatocyte growth factor activator http://www.genome.jp/dbget-bin/www_bget?ko:K09631 Q6QNF4 410 2.5e-38 Hepatocyte growth factor activator OS=Canis familiaris GN=HGFAC PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.14511 BF_2 268.11 6.24 2084 642925172 XP_001810693.2 1621 1.5e-177 PREDICTED: endoglucanase 5-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26221 879 6.6e-93 Endoglucanase E-4 OS=Thermobifida fusca GN=celD PE=1 SV=2 PF09204//PF00759 Bacterial self-protective colicin-like immunity//Glycosyl hydrolase family 9 GO:0005975//GO:0030153//GO:0006955 carbohydrate metabolic process//bacteriocin immunity//immune response GO:0015643//GO:0004553 toxic substance binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0019814 immunoglobulin complex -- -- Cluster-8309.14513 BF_2 70.92 1.13 2919 642916865 XP_008199533.1 1683 1.3e-184 PREDICTED: transcription termination factor 2 [Tribolium castaneum]>gi|270003081|gb|EEZ99528.1| hypothetical protein TcasGA2_TC000110 [Tribolium castaneum] -- -- -- -- -- K15173 TTF2 transcription termination factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15173 P34739 1220 2.7e-132 Transcription termination factor 2 OS=Drosophila melanogaster GN=lds PE=1 SV=2 PF02742//PF04851//PF00176//PF14532 Iron dependent repressor, metal binding and dimerisation domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//Sigma-54 interaction domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0046914//GO:0003677//GO:0016787//GO:0046983//GO:0008134//GO:0003676 ATP binding//transition metal ion binding//DNA binding//hydrolase activity//protein dimerization activity//transcription factor binding//nucleic acid binding GO:0005667 transcription factor complex KOG4439 RNA polymerase II transcription termination factor TTF2/lodestar, DEAD-box superfamily Cluster-8309.14515 BF_2 16.39 0.92 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14518 BF_2 204.00 3.08 3060 499006075 XP_004535735.1 707 2.1e-71 PREDICTED: uncharacterized protein Nap1 [Ceratitis capitata] -- -- -- -- -- -- -- -- -- Q562D6 510 6.0e-50 Nef-associated protein 1 OS=Mus musculus GN=Nap1 PE=2 SV=2 PF05615 Tho complex subunit 7 GO:0006397 mRNA processing -- -- GO:0000445 THO complex part of transcription export complex KOG2942 Uncharacterized conserved protein Cluster-8309.14522 BF_2 16.76 0.91 1059 478252105 ENN72536.1 402 1.7e-36 hypothetical protein YQE_10876, partial [Dendroctonus ponderosae]>gi|546683902|gb|ERL93650.1| hypothetical protein D910_10938 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14524 BF_2 2.50 1.64 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14526 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14527 BF_2 31.00 3.29 681 -- -- -- -- -- 571032407 KC769593.1 61 3.65206e-21 Ornithodoros brasiliensis mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14528 BF_2 16.08 0.53 1563 546684056 ERL93779.1 1614 7.1e-177 hypothetical protein D910_11065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P97535 312 2.8e-27 Phospholipase A1 member A OS=Rattus norvegicus GN=Pla1a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14535 BF_2 5.00 0.70 588 159145680 ABW90377.1 511 2.1e-49 putative ribosomal protein S10 [Sipunculus nudus] 884979402 XM_010864134.2 45 2.45186e-12 PREDICTED: Esox lucius plectin (LOC105005886), transcript variant X17, mRNA K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 Q90YR4 481 2.6e-47 40S ribosomal protein S10 OS=Ictalurus punctatus GN=rps10 PE=2 SV=1 PF03720 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain GO:0055114 oxidation-reduction process GO:0016616//GO:0051287 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG3344 40s ribosomal protein s10 Cluster-8309.14536 BF_2 92.01 0.97 4250 642910790 XP_008193412.1 598 1.3e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ02 306 3.7e-26 COMM domain-containing protein 4 OS=Mus musculus GN=Commd4 PE=2 SV=1 PF10538//PF05434 Immunoreceptor tyrosine-based activation motif//TMEM9 GO:0007165 signal transduction -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.14539 BF_2 8.00 0.75 731 16903179 AAK61417.1 467 3.3e-44 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00367 phosphotransferase system, EIIB GO:0008643 carbohydrate transport GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.14546 BF_2 6.00 0.69 650 799368377 AKA64754.1 459 2.5e-43 C-type lectin 4 [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14547 BF_2 167.25 6.55 1356 546673531 ERL85114.1 427 2.7e-39 hypothetical protein D910_02536 [Dendroctonus ponderosae] -- -- -- -- -- K02520 infC, MTIF3 translation initiation factor IF-3 http://www.genome.jp/dbget-bin/www_bget?ko:K02520 Q32KZ1 138 3.6e-07 Translation initiation factor IF-3, mitochondrial OS=Bos taurus GN=MTIF3 PE=2 SV=1 PF00707//PF00582//PF05198 Translation initiation factor IF-3, C-terminal domain//Universal stress protein family//Translation initiation factor IF-3, N-terminal domain GO:0006446//GO:0006413//GO:0006950 regulation of translational initiation//translational initiation//response to stress GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.14551 BF_2 8.00 0.88 669 545187263 XP_003362957.2 661 9.8e-67 PREDICTED: 60S ribosomal protein L19-like [Equus caballus] 92446006 BC064505.1 669 0 Homo sapiens cDNA clone IMAGE:6536313, **** WARNING: chimeric clone **** K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 Q5RB99 657 1.2e-67 60S ribosomal protein L19 OS=Pongo abelii GN=RPL19 PE=2 SV=1 PF01280 Ribosomal protein L19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1696 60s ribosomal protein L19 Cluster-8309.14553 BF_2 60.00 3.01 1121 642910408 XP_008190721.1 355 5.0e-31 PREDICTED: UPF0235 protein C15orf40 homolog [Tribolium castaneum] -- -- -- -- -- K09131 K09131 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K09131 Q8WUR7 210 1.3e-15 UPF0235 protein C15orf40 OS=Homo sapiens GN=C15orf40 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3276 Uncharacterized conserved protein, contains YggU domain Cluster-8309.14567 BF_2 28.51 1.97 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q6NXE6 125 7.6e-06 Armadillo repeat-containing protein 6 OS=Homo sapiens GN=ARMC6 PE=1 SV=2 PF04098//PF01031 Rad52/22 family double-strand break repair protein//Dynamin central region GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0005525 GTP binding -- -- -- -- Cluster-8309.14570 BF_2 5.00 0.31 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14571 BF_2 26.00 1.19 1201 390362249 XP_001190749.2 311 6.8e-26 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q4UMH6 270 1.6e-22 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14588 BF_2 20.00 1.28 940 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14591 BF_2 47.00 1.42 1674 546683892 ERL93640.1 316 2.5e-26 hypothetical protein D910_10928, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13374 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14594 BF_2 9.00 0.46 1104 478252093 ENN72524.1 145 1.1e-06 hypothetical protein YQE_10864, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06337 DUSP domain GO:0016579//GO:0006508 protein deubiquitination//proteolysis GO:0004843 ubiquitin-specific protease activity -- -- -- -- Cluster-8309.14597 BF_2 6.00 0.31 1089 339258904 XP_003369638.1 233 6.8e-17 reverse transcriptase family protein [Trichinella spiralis]>gi|316966062|gb|EFV50696.1| reverse transcriptase family protein [Trichinella spiralis] -- -- -- -- -- -- -- -- -- P20825 146 3.4e-08 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.146 BF_2 4.00 0.32 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14601 BF_2 2.00 0.47 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14602 BF_2 15.00 0.42 1766 241999408 XP_002434347.1 1461 4.4e-159 glyceraldehyde 3-phosphate dehydrogenase, putative [Ixodes scapularis]>gi|215497677|gb|EEC07171.1| glyceraldehyde 3-phosphate dehydrogenase, putative [Ixodes scapularis] 178948393 EU596367.1 189 6.83891e-92 Phytophthora sp. KACC 40914 glyceraldehyde-3-phosphate dehydrogenase-like gene, partial sequence K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q5R2J2 1247 1.2e-135 Glyceraldehyde-3-phosphate dehydrogenase OS=Pelodiscus sinensis GN=GAPDH PE=2 SV=1 PF02800//PF00044//PF02826 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006096//GO:0006006//GO:0006094//GO:0055114 glycolytic process//glucose metabolic process//gluconeogenesis//oxidation-reduction process GO:0050661//GO:0051287//GO:0004365//GO:0016620 NADP binding//NAD binding//glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.14603 BF_2 5.00 0.53 685 241851549 XP_002415781.1 601 9.0e-60 ribosomal protein L19, putative [Ixodes scapularis]>gi|215509995|gb|EEC19448.1| ribosomal protein L19, putative [Ixodes scapularis] 665403631 NM_206219.2 169 3.37556e-81 Drosophila melanogaster ribosomal protein L19 (RpL19), transcript variant B, mRNA K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 P36241 575 3.8e-58 60S ribosomal protein L19 OS=Drosophila melanogaster GN=RpL19 PE=1 SV=2 PF01280 Ribosomal protein L19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1696 60s ribosomal protein L19 Cluster-8309.14605 BF_2 64.98 4.93 838 642933664 XP_008197512.1 334 1.0e-28 PREDICTED: bifunctional coenzyme A synthase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K02318 COASY phosphopantetheine adenylyltransferase / dephospho-CoA kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02318 Q8MIR4 242 1.9e-19 Bifunctional coenzyme A synthase OS=Sus scrofa GN=COASY PE=1 SV=1 PF01121//PF03861 Dephospho-CoA kinase//ANTAR domain GO:0015940//GO:0015937 pantothenate biosynthetic process//coenzyme A biosynthetic process GO:0003723//GO:0005524//GO:0004140 RNA binding//ATP binding//dephospho-CoA kinase activity -- -- KOG3220 Similar to bacterial dephospho-CoA kinase Cluster-8309.14607 BF_2 70.75 1.00 3256 642922652 XP_008193262.1 1318 3.1e-142 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 758 1.1e-78 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF09606//PF16987//PF02172 ARC105 or Med15 subunit of Mediator complex non-fungal//KIX domain//KIX domain GO:0006355//GO:0006357 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0003712 RNA polymerase II transcription cofactor activity//transcription cofactor activity GO:0005667//GO:0016592 transcription factor complex//mediator complex -- -- Cluster-8309.14608 BF_2 20.26 2.41 639 546681934 ERL91930.1 299 8.9e-25 hypothetical protein D910_09253 [Dendroctonus ponderosae] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 261 9.3e-22 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF16987//PF02172//PF09606 KIX domain//KIX domain//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005667 mediator complex//transcription factor complex -- -- Cluster-8309.14620 BF_2 120.00 4.40 1427 642914937 XP_008190449.1 1108 3.1e-118 PREDICTED: cytokine receptor-like factor 3 [Tribolium castaneum]>gi|270001393|gb|EEZ97840.1| hypothetical protein TcasGA2_TC000209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z2L7 466 3.5e-45 Cytokine receptor-like factor 3 OS=Mus musculus GN=Crlf3 PE=2 SV=1 PF16656//PF00076 Purple acid Phosphatase, N-terminal domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0003993//GO:0003676 metal ion binding//acid phosphatase activity//nucleic acid binding -- -- -- -- Cluster-8309.14626 BF_2 11.00 0.52 1170 270000722 EEZ97169.1 479 2.2e-45 hypothetical protein TcasGA2_TC004356 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 P52735 284 3.7e-24 Guanine nucleotide exchange factor VAV2 OS=Homo sapiens GN=VAV2 PE=1 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.14630 BF_2 1.00 0.51 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14632 BF_2 287.50 8.13 1766 642930318 XP_972929.2 2050 2.2e-227 PREDICTED: WD repeat-containing protein 20 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBZ3 1084 9.5e-117 WD repeat-containing protein 20 OS=Homo sapiens GN=WDR20 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2394 WD40 protein DMR-N9 Cluster-8309.14633 BF_2 10.50 0.31 1708 642930318 XP_972929.2 1029 5.3e-109 PREDICTED: WD repeat-containing protein 20 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBZ3 674 3.2e-69 WD repeat-containing protein 20 OS=Homo sapiens GN=WDR20 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2394 WD40 protein DMR-N9 Cluster-8309.14635 BF_2 4.00 0.78 501 25247488 AAN72821.1 544 2.7e-53 beta-I tubulin [Callinectes sapidus] 25247487 AY166605.1 254 1.36115e-128 Callinectes sapidus beta-I tubulin mRNA, partial cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q25009 540 3.2e-54 Tubulin beta-1 chain OS=Homarus americanus PE=2 SV=1 PF13361 UvrD-like helicase C-terminal domain -- -- GO:0016787//GO:0005524 hydrolase activity//ATP binding -- -- KOG1375 Beta tubulin Cluster-8309.14643 BF_2 8.00 0.64 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14644 BF_2 11.00 0.73 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14648 BF_2 10.00 1.02 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14652 BF_2 20.60 0.60 1728 189237912 XP_969631.2 1784 1.5e-196 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q92830 1147 4.6e-124 Histone acetyltransferase KAT2A OS=Homo sapiens GN=KAT2A PE=1 SV=3 PF06466//PF13508//PF00583 PCAF (P300/CBP-associated factor) N-terminal domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967//GO:0044260//GO:0044238//GO:0006355 acyl-carrier-protein biosynthetic process//cellular macromolecule metabolic process//primary metabolic process//regulation of transcription, DNA-templated GO:0008080//GO:0004402 N-acetyltransferase activity//histone acetyltransferase activity GO:0005634//GO:0000123 nucleus//histone acetyltransferase complex KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.14658 BF_2 19.00 0.47 1984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14660 BF_2 92.00 6.07 921 642939617 XP_008193743.1 445 1.5e-41 PREDICTED: mitochondrial cardiolipin hydrolase-like [Tribolium castaneum]>gi|270016770|gb|EFA13216.1| hypothetical protein TcasGA2_TC010319 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2A8 151 7.6e-09 Mitochondrial cardiolipin hydrolase OS=Homo sapiens GN=PLD6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14664 BF_2 2.00 2.63 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14665 BF_2 5.70 0.35 961 478256130 ENN76329.1 708 5.0e-72 hypothetical protein YQE_07292, partial [Dendroctonus ponderosae]>gi|546675872|gb|ERL86977.1| hypothetical protein D910_04380 [Dendroctonus ponderosae] -- -- -- -- -- K07556 ATPeAF2, ATPAF2, ATP12 ATP synthase mitochondrial F1 complex assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07556 Q1LZ96 431 2.7e-41 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Bos taurus GN=ATPAF2 PE=2 SV=1 PF07542 ATP12 chaperone protein GO:0043461 proton-transporting ATP synthase complex assembly -- -- -- -- KOG3015 F1-ATP synthase assembly protein Cluster-8309.14666 BF_2 7.18 0.47 929 478256130 ENN76329.1 938 1.0e-98 hypothetical protein YQE_07292, partial [Dendroctonus ponderosae]>gi|546675872|gb|ERL86977.1| hypothetical protein D910_04380 [Dendroctonus ponderosae] -- -- -- -- -- K07556 ATPeAF2, ATPAF2, ATP12 ATP synthase mitochondrial F1 complex assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07556 Q1LZ96 572 1.2e-57 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Bos taurus GN=ATPAF2 PE=2 SV=1 PF07542 ATP12 chaperone protein GO:0043461 proton-transporting ATP synthase complex assembly -- -- -- -- KOG3015 F1-ATP synthase assembly protein Cluster-8309.14674 BF_2 2.00 1.49 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14676 BF_2 5.00 0.59 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14680 BF_2 26.81 0.40 3088 270008864 EFA05312.1 1430 3.1e-155 hypothetical protein TcasGA2_TC015470 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04146 1051 1.1e-112 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF13683//PF00665//PF00098//PF02932 Integrase core domain//Integrase core domain//Zinc knuckle//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0015074 ion transport//DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0016020 membrane -- -- Cluster-8309.14683 BF_2 127.46 2.73 2243 642928303 XP_008195525.1 1013 5.0e-107 PREDICTED: putative glycerol kinase 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19583 GK5 putative glycerol kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K19583 Q08D86 760 4.5e-79 Putative glycerol kinase 5 OS=Bos taurus GN=GK5 PE=2 SV=1 PF00370//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.14687 BF_2 8.00 5.23 346 685564024 XP_009213478.1 425 1.2e-39 PREDICTED: 40S ribosomal protein S27-like [Papio anubis] 694939145 XM_003312498.3 344 8.48167e-179 PREDICTED: Pan troglodytes 40S ribosomal protein S27 (LOC100614845), mRNA K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 P55833 353 1.1e-32 40S ribosomal protein S27 OS=Homarus americanus GN=RPS27 PE=3 SV=2 PF00527//PF01667 E7 protein, Early protein//Ribosomal protein S27 GO:0006412//GO:0042254//GO:0006355 translation//ribosome biogenesis//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0003735 DNA binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome GO:0005667//GO:0005840//GO:0005622 transcription factor complex//ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.14688 BF_2 6.00 0.81 596 478256535 ENN76719.1 248 6.8e-19 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N823 192 8.7e-14 Zinc finger protein 611 OS=Homo sapiens GN=ZNF611 PE=2 SV=2 PF02025//PF00096//PF13465//PF05743//PF00628//PF16622//PF05191 Interleukin 5//Zinc finger, C2H2 type//Zinc-finger double domain//UEV domain//PHD-finger//zinc-finger C2H2-type//Adenylate kinase, active site lid GO:0040007//GO:0007165//GO:0006464//GO:0008283//GO:0006144//GO:0046034//GO:0006955//GO:0015031 growth//signal transduction//cellular protein modification process//cell proliferation//purine nucleobase metabolic process//ATP metabolic process//immune response//protein transport GO:0008083//GO:0005515//GO:0004017//GO:0005137//GO:0046872 growth factor activity//protein binding//adenylate kinase activity//interleukin-5 receptor binding//metal ion binding GO:0005895//GO:0005576 interleukin-5 receptor complex//extracellular region -- -- Cluster-8309.14692 BF_2 10.00 0.43 1271 826414684 XP_012522035.1 184 3.8e-11 PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414686|ref|XP_012522036.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414688|ref|XP_012522037.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414690|ref|XP_012522038.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414692|ref|XP_012522039.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis]>gi|826414694|ref|XP_012522041.1| PREDICTED: uncharacterized protein LOC105828318 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14700 BF_2 110.10 5.50 1124 642911268 XP_972818.2 1129 8.9e-121 PREDICTED: NAD-dependent protein deacylase [Tribolium castaneum] -- -- -- -- -- K11415 SIRT5, SIR2L5 NAD-dependent deacetylase sirtuin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11415 E9GD30 807 7.9e-85 NAD-dependent protein deacylase OS=Daphnia pulex GN=DAPPUDRAFT_195469 PE=3 SV=1 PF02146//PF00205//PF02233 Sir2 family//Thiamine pyrophosphate enzyme, central domain//NAD(P) transhydrogenase beta subunit GO:0046497//GO:0006769//GO:0055114 nicotinate nucleotide metabolic process//nicotinamide metabolic process//oxidation-reduction process GO:0008750//GO:0070403//GO:0050661//GO:0000287//GO:0030976 NAD(P)+ transhydrogenase (AB-specific) activity//NAD+ binding//NADP binding//magnesium ion binding//thiamine pyrophosphate binding GO:0016021 integral component of membrane KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.14701 BF_2 49.41 0.82 2802 642917105 XP_008191117.1 1454 4.6e-158 PREDICTED: trimethylguanosine synthase isoform X3 [Tribolium castaneum] -- -- -- -- -- K14292 TGS1 trimethylguanosine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14292 Q923W1 629 8.7e-64 Trimethylguanosine synthase OS=Mus musculus GN=Tgs1 PE=1 SV=2 PF09452//PF01596//PF03602//PF05401//PF01795//PF05175//PF08241//PF09445//PF02005 ESCRT-I subunit Mvb12//O-methyltransferase//Conserved hypothetical protein 95//Nodulation protein S (NodS)//MraW methylase family//Methyltransferase small domain//Methyltransferase domain//RNA cap guanine-N2 methyltransferase//N2,N2-dimethylguanosine tRNA methyltransferase GO:0008033//GO:0009312//GO:0031167//GO:0032509//GO:0009451//GO:0009877//GO:0001510//GO:0009452//GO:0008152 tRNA processing//oligosaccharide biosynthetic process//rRNA methylation//endosome transport via multivesicular body sorting pathway//RNA modification//nodulation//RNA methylation//7-methylguanosine RNA capping//metabolic process GO:0004809//GO:0008168//GO:0008171//GO:0008757//GO:0043130//GO:0003723 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//O-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//ubiquitin binding//RNA binding GO:0000813 ESCRT I complex KOG2730 Methylase Cluster-8309.14702 BF_2 241.41 4.24 2671 642917105 XP_008191117.1 1454 4.3e-158 PREDICTED: trimethylguanosine synthase isoform X3 [Tribolium castaneum] -- -- -- -- -- K14292 TGS1 trimethylguanosine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14292 Q923W1 629 8.3e-64 Trimethylguanosine synthase OS=Mus musculus GN=Tgs1 PE=1 SV=2 PF02005//PF09445//PF03602//PF05175//PF09452//PF08241//PF01596 N2,N2-dimethylguanosine tRNA methyltransferase//RNA cap guanine-N2 methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain//ESCRT-I subunit Mvb12//Methyltransferase domain//O-methyltransferase GO:0008033//GO:0009451//GO:0032509//GO:0031167//GO:0008152//GO:0009452//GO:0001510 tRNA processing//RNA modification//endosome transport via multivesicular body sorting pathway//rRNA methylation//metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0008168//GO:0004809//GO:0003723//GO:0043130//GO:0008171 methyltransferase activity//tRNA (guanine-N2-)-methyltransferase activity//RNA binding//ubiquitin binding//O-methyltransferase activity GO:0000813 ESCRT I complex KOG2730 Methylase Cluster-8309.14704 BF_2 29.00 1.42 1139 642934124 XP_008199287.1 1097 4.6e-117 PREDICTED: aurora kinase C [Tribolium castaneum]>gi|270014218|gb|EFA10666.1| IplI-aurora-like kinase [Tribolium castaneum] -- -- -- -- -- K11479 AURKB aurora kinase B http://www.genome.jp/dbget-bin/www_bget?ko:K11479 Q9VKN7 873 1.8e-92 Aurora kinase B OS=Drosophila melanogaster GN=ial PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004672//GO:0004674//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.14705 BF_2 1.00 5.13 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14706 BF_2 21.16 0.56 1881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14707 BF_2 62.00 1.45 2082 270001576 EEZ98023.1 814 5.5e-84 hypothetical protein TcasGA2_TC000423 [Tribolium castaneum] -- -- -- -- -- K06838 SLIT1 slit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06838 Q80X72 172 6.3e-11 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.1471 BF_2 3.14 0.70 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14712 BF_2 50.04 0.64 3547 728418700 AIY68378.1 792 3.3e-81 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 P16854 462 2.5e-44 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.14716 BF_2 440.00 3.32 5831 642921515 XP_008192902.1 1362 4.4e-147 PREDICTED: coiled-coil domain-containing protein 22 homolog, partial [Tribolium castaneum] -- -- -- -- -- K09191 GTF3A general transcription factor IIIA http://www.genome.jp/dbget-bin/www_bget?ko:K09191 Q16VW9 691 1.2e-70 Coiled-coil domain-containing protein 22 homolog OS=Aedes aegypti GN=AAEL009388 PE=3 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.14719 BF_2 12.00 1.08 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14724 BF_2 147.00 13.79 733 642923172 XP_008193639.1 606 2.6e-60 PREDICTED: protein archease-like [Tribolium castaneum]>gi|270007591|gb|EFA04039.1| hypothetical protein TcasGA2_TC014269 [Tribolium castaneum] 847100090 XM_012956998.1 41 5.17666e-10 PREDICTED: Xenopus (Silurana) tropicalis zinc finger and BTB domain containing 8 opposite strand (zbtb8os), transcript variant X1, mRNA -- -- -- -- Q9VD92 461 6.9e-45 Protein archease-like OS=Drosophila melanogaster GN=CG6353 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4528 Uncharacterized conserved protein Cluster-8309.14725 BF_2 18.28 0.33 2639 270002520 EEZ98967.1 1586 2.1e-173 hypothetical protein TcasGA2_TC004822 [Tribolium castaneum] -- -- -- -- -- K08619 ADAMTS3 a disintegrin and metalloproteinase with thrombospondin motifs 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08619 O15072 682 5.8e-70 A disintegrin and metalloproteinase with thrombospondin motifs 3 OS=Homo sapiens GN=ADAMTS3 PE=2 SV=4 PF00413//PF01421 Matrixin//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix -- -- Cluster-8309.1473 BF_2 16.00 0.75 1182 478255644 ENN75856.1 770 4.0e-79 hypothetical protein YQE_07585, partial [Dendroctonus ponderosae]>gi|546678128|gb|ERL88837.1| hypothetical protein D910_06219 [Dendroctonus ponderosae] -- -- -- -- -- K08865 PBK PDZ-binding kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08865 Q96KB5 494 1.6e-48 Lymphokine-activated killer T-cell-originated protein kinase OS=Homo sapiens GN=PBK PE=1 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0192 Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs Cluster-8309.14730 BF_2 3.00 0.97 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14731 BF_2 168.30 13.11 824 91076134 XP_970027.1 632 2.8e-63 PREDICTED: uncharacterized protein LOC658556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14733 BF_2 66.56 4.51 905 91086897 XP_970798.1 615 2.9e-61 PREDICTED: kxDL motif-containing protein CG10681 [Tribolium castaneum]>gi|270010480|gb|EFA06928.1| hypothetical protein TcasGA2_TC009878 [Tribolium castaneum] 571525050 XM_001122056.3 100 1.02724e-42 PREDICTED: Apis mellifera UPF0459 protein CG10681-like (LOC726308), mRNA -- -- -- -- Q9VTY4 332 7.7e-30 KxDL motif-containing protein CG10681 OS=Drosophila melanogaster GN=CG10681 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3443 Uncharacterized conserved protein Cluster-8309.14734 BF_2 3.44 0.90 447 91086897 XP_970798.1 252 1.7e-19 PREDICTED: kxDL motif-containing protein CG10681 [Tribolium castaneum]>gi|270010480|gb|EFA06928.1| hypothetical protein TcasGA2_TC009878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTY4 137 1.5e-07 KxDL motif-containing protein CG10681 OS=Drosophila melanogaster GN=CG10681 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14736 BF_2 49.69 1.68 1527 91091194 XP_972244.1 768 8.7e-79 PREDICTED: superoxide dismutase [Cu-Zn] [Tribolium castaneum]>gi|270014236|gb|EFA10684.1| hypothetical protein TcasGA2_TC011675 [Tribolium castaneum] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 373 2.3e-34 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801//GO:0008152 oxidation-reduction process//superoxide metabolic process//metabolic process GO:0046872//GO:0016491 metal ion binding//oxidoreductase activity -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.14741 BF_2 3.00 0.51 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14742 BF_2 12.58 2.38 508 645028691 XP_008208512.1 312 2.2e-26 PREDICTED: uncharacterized protein LOC100115997 [Nasonia vitripennis] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q84TF0 176 5.3e-12 Aldo-keto reductase family 4 member C10 OS=Arabidopsis thaliana GN=AKR4C10 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.14750 BF_2 20.38 2.14 686 665816551 XP_008556999.1 157 2.8e-08 PREDICTED: fatty acid synthase-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P19096 123 1.0e-05 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.14754 BF_2 35.00 0.91 1893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14756 BF_2 69.31 18.32 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1476 BF_2 30.20 0.81 1840 642937584 XP_008199108.1 1425 6.9e-155 PREDICTED: fidgetin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IHT0 1083 1.3e-116 Fidgetin-like protein 1 OS=Xenopus tropicalis GN=fignl1 PE=2 SV=1 PF07724//PF00004//PF06068//PF00158//PF05496//PF07728//PF01695 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//TIP49 C-terminus//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006310//GO:0006355//GO:0006281 DNA recombination//regulation of transcription, DNA-templated//DNA repair GO:0016887//GO:0009378//GO:0005524//GO:0003678//GO:0008134 ATPase activity//four-way junction helicase activity//ATP binding//DNA helicase activity//transcription factor binding GO:0005657//GO:0009379//GO:0005667 replication fork//Holliday junction helicase complex//transcription factor complex KOG0740 AAA+-type ATPase Cluster-8309.14765 BF_2 181.86 2.38 3478 332376194 AEE63237.1 1073 8.6e-114 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 A6QQF5 368 2.0e-33 Quinone oxidoreductase-like protein 2 OS=Bos taurus PE=2 SV=2 PF00107//PF08254//PF08240 Zinc-binding dehydrogenase//Threonine leader peptide//Alcohol dehydrogenase GroES-like domain GO:0009088//GO:0031556//GO:0031554//GO:0055114 threonine biosynthetic process//transcriptional attenuation by ribosome//regulation of DNA-templated transcription, termination//oxidation-reduction process -- -- -- -- -- -- Cluster-8309.14767 BF_2 30.67 0.32 4295 478249964 ENN70471.1 1379 3.5e-149 hypothetical protein YQE_12974, partial [Dendroctonus ponderosae] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q5BKQ4 455 2.0e-43 Inactive pancreatic lipase-related protein 1 OS=Mus musculus GN=Pnliprp1 PE=2 SV=2 PF08240//PF00107//PF01764 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase//Lipase (class 3) GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process -- -- -- -- -- -- Cluster-8309.14768 BF_2 109.47 1.16 4240 270012898 EFA09346.1 2263 1.1e-251 hypothetical protein TcasGA2_TC001672 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q64425 822 5.5e-86 Pancreatic triacylglycerol lipase (Fragment) OS=Myocastor coypus GN=PNLIP PE=2 SV=1 PF08240//PF01764//PF00107 Alcohol dehydrogenase GroES-like domain//Lipase (class 3)//Zinc-binding dehydrogenase GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process -- -- -- -- -- -- Cluster-8309.14771 BF_2 49.00 1.13 2109 478250167 ENN70670.1 291 2.5e-23 hypothetical protein YQE_12615, partial [Dendroctonus ponderosae]>gi|478270480|gb|ENN83518.1| hypothetical protein YQE_00125, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBI2 154 7.8e-09 THAP domain-containing protein 4 OS=Bos taurus GN=THAP4 PE=2 SV=2 PF01064 Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0007178 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.14775 BF_2 11.00 0.69 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14776 BF_2 4.00 0.82 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14777 BF_2 8.00 0.61 840 260806989 XP_002598366.1 862 6.0e-90 hypothetical protein BRAFLDRAFT_69722 [Branchiostoma floridae]>gi|229283638|gb|EEN54378.1| hypothetical protein BRAFLDRAFT_69722 [Branchiostoma floridae] 195173580 XM_002027530.1 40 2.14687e-09 Drosophila persimilis GL18386 (Dper\GL18386), mRNA >gnl|BL_ORD_ID|5702852 Drosophila pseudoobscura pseudoobscura GA15280 (Dpse\GA15280), partial mRNA K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 Q4PM31 838 1.5e-88 40S ribosomal protein S3a OS=Ixodes scapularis PE=2 SV=1 PF01015//PF04083 Ribosomal S3Ae family//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0006412//GO:0042254 lipid metabolic process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1628 40S ribosomal protein S3A Cluster-8309.14780 BF_2 19.73 0.37 2545 642939462 XP_008200412.1 1546 8.9e-169 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 666 4.0e-68 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.14781 BF_2 20.19 0.39 2469 642939462 XP_008200412.1 1546 8.6e-169 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 666 3.9e-68 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.14785 BF_2 182.22 6.16 1525 642912272 XP_008200632.1 555 4.4e-54 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CHN8 212 1.1e-15 Mannan-binding lectin serine protease 1 OS=Rattus norvegicus GN=Masp1 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.14790 BF_2 13.82 5.16 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14792 BF_2 190.00 14.02 854 91090518 XP_969863.1 621 5.4e-62 PREDICTED: splicing factor 3B subunit 6 [Tribolium castaneum]>gi|270013874|gb|EFA10322.1| hypothetical protein TcasGA2_TC012538 [Tribolium castaneum] 505828152 XM_004609330.1 91 9.73957e-38 PREDICTED: Sorex araneus splicing factor 3b, subunit 6, 14kDa (SF3B6), mRNA K12833 SF3B14 pre-mRNA branch site protein p14 http://www.genome.jp/dbget-bin/www_bget?ko:K12833 P59708 535 2.1e-53 Splicing factor 3B subunit 6 OS=Mus musculus GN=Sf3b6 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0114 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.14800 BF_2 15.00 1.63 671 391341402 XP_003745019.1 482 5.6e-46 PREDICTED: elongation factor 1-alpha 1-like [Metaseiulus occidentalis] 198460843 XM_001361784.2 163 7.14967e-78 Drosophila pseudoobscura pseudoobscura GA20951 (Dpse\GA20951), partial mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q05639 450 1.2e-43 Elongation factor 1-alpha 2 OS=Homo sapiens GN=EEF1A2 PE=1 SV=1 PF02774//PF03491 Semialdehyde dehydrogenase, dimerisation domain//Serotonin (5-HT) neurotransmitter transporter, N-terminus GO:0000051//GO:0006836//GO:0055114//GO:0006812//GO:0008652 obsolete urea cycle intermediate metabolic process//neurotransmitter transport//oxidation-reduction process//cation transport//cellular amino acid biosynthetic process GO:0046983//GO:0005335//GO:0016620//GO:0003942 protein dimerization activity//serotonin:sodium symporter activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//N-acetyl-gamma-glutamyl-phosphate reductase activity GO:0005887//GO:0005737 integral component of plasma membrane//cytoplasm KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.14801 BF_2 36.00 2.51 888 13122852 AAK12667.1 1456 8.5e-159 elongation factor-1alpha, partial [Sejus sp. 'Sej'] 13122859 AF240860.1 436 0 Tachyuropodid 'Tac' elongation factor-1alpha mRNA, partial cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P29520 1367 7.3e-150 Elongation factor 1-alpha OS=Bombyx mori PE=2 SV=1 PF03144 Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.14802 BF_2 169.00 4.59 1829 332374336 AEE62309.1 1357 5.3e-147 unknown [Dendroctonus ponderosae]>gi|478258016|gb|ENN78154.1| hypothetical protein YQE_05308, partial [Dendroctonus ponderosae]>gi|546682517|gb|ERL92440.1| hypothetical protein D910_09754 [Dendroctonus ponderosae] 826307347 XM_012649122.1 135 7.39515e-62 PREDICTED: Propithecus coquereli RAD51 recombinase (RAD51), mRNA K04482 RAD51 DNA repair protein RAD51 http://www.genome.jp/dbget-bin/www_bget?ko:K04482 Q06609 1348 2.4e-147 DNA repair protein RAD51 homolog 1 OS=Homo sapiens GN=RAD51 PE=1 SV=1 PF00006//PF00154//PF05625 ATP synthase alpha/beta family, nucleotide-binding domain//recA bacterial DNA recombination protein//PAXNEB protein GO:0009432//GO:0006281 SOS response//DNA repair GO:0003697//GO:0005524 single-stranded DNA binding//ATP binding GO:0033588 Elongator holoenzyme complex KOG1433 DNA repair protein RAD51/RHP55 Cluster-8309.14804 BF_2 6.06 0.32 1072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14807 BF_2 10.00 1.73 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14808 BF_2 11.00 0.99 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14809 BF_2 17.00 0.35 2292 270016726 EFA13172.1 636 2.7e-63 hypothetical protein TcasGA2_TC001813 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 431 6.5e-41 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.14811 BF_2 6.00 0.63 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14812 BF_2 5.00 1.66 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14814 BF_2 45.64 0.57 3641 642932799 XP_008196988.1 4010 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X2 [Tribolium castaneum]>gi|270012453|gb|EFA08901.1| hypothetical protein TcasGA2_TC006604 [Tribolium castaneum] 642932798 XM_008198766.1 147 3.17052e-68 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1929 2.0e-214 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF14634//PF12861//PF17123//PF17122//PF00097//PF00637//PF13639 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Region in Clathrin and VPS//Ring finger domain GO:0006886//GO:0016567//GO:0016192 intracellular protein transport//protein ubiquitination//vesicle-mediated transport GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680//GO:0005622 anaphase-promoting complex//intracellular KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.14818 BF_2 123.05 1.52 3669 815897996 XP_012249713.1 1002 1.5e-105 PREDICTED: histone deacetylase 6 [Bombus impatiens] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 742 8.9e-77 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 PF06220 U1 zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.14821 BF_2 13.00 0.31 2028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07244 Surface antigen variable number repeat -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.14826 BF_2 15.00 0.65 1255 751236503 XP_011172088.1 896 1.0e-93 PREDICTED: GTP cyclohydrolase 1 [Solenopsis invicta] 241989293 AK336271.1 231 2.1646e-115 Triticum aestivum cDNA, clone: SET3_K11, cultivar: Chinese Spring K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 873 2.0e-92 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 PF14489 QueF-like protein GO:0008616 queuosine biosynthetic process GO:0033739 preQ1 synthase activity -- -- KOG2698 GTP cyclohydrolase I Cluster-8309.1483 BF_2 13.00 1.61 624 112180627 AAH70248.1 341 1.2e-29 TMSB4X protein, partial [Homo sapiens]>gi|112180667|gb|AAH92437.1| TMSB4X protein, partial [Homo sapiens] 18605541 BC022857.1 614 0 Homo sapiens thymosin beta 4, X-linked, mRNA (cDNA clone IMAGE:4095465), partial cds K05764 TMSB4 thymosin, beta 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05764 P20065 231 2.7e-18 Thymosin beta-4 OS=Mus musculus GN=Tmsb4x PE=1 SV=1 PF01290//PF02205 Thymosin beta-4 family//WH2 motif GO:0030334//GO:0042989//GO:0007015//GO:0030168//GO:0001649//GO:0002576 regulation of cell migration//sequestering of actin monomers//actin filament organization//platelet activation//osteoblast differentiation//platelet degranulation GO:0003779//GO:0003785 actin binding//actin monomer binding GO:0005829//GO:0005634//GO:0005856//GO:0031093//GO:0005576 cytosol//nucleus//cytoskeleton//platelet alpha granule lumen//extracellular region -- -- Cluster-8309.14831 BF_2 106.25 4.02 1392 642932333 XP_008197070.1 234 6.6e-17 PREDICTED: uncharacterized protein LOC103314052 [Tribolium castaneum]>gi|270011613|gb|EFA08061.1| hypothetical protein TcasGA2_TC005657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.14835 BF_2 58.88 0.39 6635 642940052 XP_008200969.1 2767 6.2e-310 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULI0 1241 2.2e-134 ATPase family AAA domain-containing protein 2B OS=Homo sapiens GN=ATAD2B PE=1 SV=3 PF00005//PF04851//PF00910//PF01695//PF07728//PF05496//PF01057//PF06068//PF00004//PF00439//PF07724 ABC transporter//Type III restriction enzyme, res subunit//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Parvovirus non-structural protein NS1//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Bromodomain//AAA domain (Cdc48 subfamily) GO:0006310//GO:0006281//GO:0019079 DNA recombination//DNA repair//viral genome replication GO:0009378//GO:0003724//GO:0016887//GO:0005515//GO:0016787//GO:0003677//GO:0003678//GO:0005524//GO:0003723 four-way junction helicase activity//RNA helicase activity//ATPase activity//protein binding//hydrolase activity//DNA binding//DNA helicase activity//ATP binding//RNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.14837 BF_2 88.28 1.26 3210 270014457 EFA10905.1 278 1.2e-21 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.1484 BF_2 3.00 0.40 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14848 BF_2 8.00 0.43 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14850 BF_2 2.00 2.09 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14854 BF_2 1.00 0.33 412 149286942 ABR23370.1 318 3.6e-27 60S ribosomal protein L22 [Ornithodoros parkeri] -- -- -- -- -- K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 P50886 261 6.0e-22 60S ribosomal protein L22 OS=Xenopus laevis GN=rpl22 PE=2 SV=2 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3434 60S ribosomal protein L22 Cluster-8309.14856 BF_2 44.00 0.55 3648 546682694 ERL92606.1 384 7.0e-34 hypothetical protein D910_09919 [Dendroctonus ponderosae] 642939363 XM_001807009.2 51 7.38038e-15 PREDICTED: Tribolium castaneum probable serine/threonine-protein kinase kinX (LOC100142294), mRNA -- -- -- -- -- -- -- -- PF07988//PF00379 LMSTEN motif//Insect cuticle protein GO:0006355 regulation of transcription, DNA-templated GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.14858 BF_2 10.40 0.52 1127 478250337 ENN70834.1 602 1.1e-59 hypothetical protein YQE_12498, partial [Dendroctonus ponderosae]>gi|546680057|gb|ERL90412.1| hypothetical protein D910_07761 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14860 BF_2 47.94 0.44 4850 91088309 XP_969421.1 1779 1.6e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 808 2.6e-84 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF00732 GMC oxidoreductase//GMC oxidoreductase GO:0055114 oxidation-reduction process GO:0050660//GO:0016614 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.14863 BF_2 304.65 3.70 3734 642936804 XP_008199623.1 2898 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 4.2e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF09726//PF02562//PF03836//PF00769//PF08702//PF00910//PF06156//PF01443//PF03796//PF07728//PF01695//PF08172//PF13851//PF00004 Transmembrane protein//PhoH-like protein//RasGAP C-terminus//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//RNA helicase//Protein of unknown function (DUF972)//Viral (Superfamily 1) RNA helicase//DnaB-like helicase C terminal domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//CASP C terminal//Growth-arrest specific micro-tubule binding//ATPase family associated with various cellular activities (AAA) GO:0030168//GO:0007264//GO:0006891//GO:0048870//GO:0006260//GO:0007165//GO:0051258 platelet activation//small GTPase mediated signal transduction//intra-Golgi vesicle-mediated transport//cell motility//DNA replication//signal transduction//protein polymerization GO:0030674//GO:0003724//GO:0008092//GO:0003723//GO:0003678//GO:0016887//GO:0005102//GO:0005524//GO:0005096 protein binding, bridging//RNA helicase activity//cytoskeletal protein binding//RNA binding//DNA helicase activity//ATPase activity//receptor binding//ATP binding//GTPase activator activity GO:0030173//GO:0005657//GO:0005577//GO:0005737//GO:0016021//GO:0019898//GO:0031514 integral component of Golgi membrane//replication fork//fibrinogen complex//cytoplasm//integral component of membrane//extrinsic component of membrane//motile cilium -- -- Cluster-8309.14864 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14865 BF_2 2.00 0.38 510 307184778 EFN71092.1 245 1.3e-18 Histone H2A [Camponotus floridanus]>gi|332031078|gb|EGI70664.1| Histone H2A [Acromyrmex echinatior]>gi|861640056|gb|KMQ93057.1| histone h2a [Lasius niger] 27556678 BX007458.1 66 4.47511e-24 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 5-PRIME end of clone FK0AAA12BG11 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84055 240 2.0e-19 Histone H2A OS=Drosophila yakuba GN=His2A PE=2 SV=2 -- -- -- -- -- -- GO:0043229 intracellular organelle -- -- Cluster-8309.14869 BF_2 91.88 0.70 5773 91092928 XP_971830.1 1416 2.4e-153 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 142 3.03665e-65 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 812 1.1e-84 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF01576//PF07851//PF07716//PF15898//PF16367//PF00076//PF03938//PF04772 Myosin tail//TMPIT-like protein//Basic region leucine zipper//cGMP-dependent protein kinase interacting domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Outer membrane protein (OmpH-like)//Influenza B matrix protein 2 (BM2) GO:0006355//GO:0015992 regulation of transcription, DNA-templated//proton transport GO:0003774//GO:1901363//GO:0019901//GO:0003676//GO:0043565//GO:0051082//GO:0097159//GO:0003700 motor activity//heterocyclic compound binding//protein kinase binding//nucleic acid binding//sequence-specific DNA binding//unfolded protein binding//organic cyclic compound binding//transcription factor activity, sequence-specific DNA binding GO:0016459//GO:0016021//GO:0005667 myosin complex//integral component of membrane//transcription factor complex -- -- Cluster-8309.14871 BF_2 67.32 1.33 2412 91092928 XP_971830.1 2228 7.0e-248 PREDICTED: ecto-NOX disulfide-thiol exchanger 2 [Tribolium castaneum]>gi|270003029|gb|EEZ99476.1| hypothetical protein TcasGA2_TC000049 [Tribolium castaneum] 642916932 XM_966737.2 521 0 PREDICTED: Tribolium castaneum ecto-NOX disulfide-thiol exchanger 2 (LOC660510), mRNA -- -- -- -- Q16206 1165 5.2e-126 Ecto-NOX disulfide-thiol exchanger 2 OS=Homo sapiens GN=ENOX2 PE=1 SV=2 PF07716//PF16367//PF00076 Basic region leucine zipper//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006355 regulation of transcription, DNA-templated GO:1901363//GO:0003676//GO:0043565//GO:0097159//GO:0003700 heterocyclic compound binding//nucleic acid binding//sequence-specific DNA binding//organic cyclic compound binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.14873 BF_2 9.00 2.02 473 311739213 ADQ01811.1 515 5.9e-50 opsin protein [Uca pugilator] -- -- -- -- -- K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 419 3.3e-40 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.14874 BF_2 56.00 2.94 1085 321452097 EFX63569.1 1002 4.6e-106 hypothetical protein DAPPUDRAFT_307030 [Daphnia pulex] 472820477 JX422192.1 52 5.97461e-16 Sycophila sp. 2 BW-2013 ultraviolet sensitive opsin mRNA, partial cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25158 935 1.1e-99 Compound eye opsin BCRH2 OS=Hemigrapsus sanguineus PE=2 SV=1 PF08496//PF00001 Peptidase family S49 N-terminal//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0004252 G-protein coupled receptor activity//serine-type endopeptidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.14877 BF_2 28.09 0.33 3841 189239732 XP_968903.2 1564 1.1e-170 PREDICTED: vitellogenin receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98163 909 4.0e-96 Putative vitellogenin receptor OS=Drosophila melanogaster GN=yl PE=1 SV=2 PF00057//PF07645//PF00008 Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.14883 BF_2 4.00 1.62 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14884 BF_2 666.00 7.85 3835 642922327 XP_008193114.1 254 8.8e-19 PREDICTED: uncharacterized protein LOC103312947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3B4 135 2.3e-06 Fas-associated death domain protein OS=Drosophila melanogaster GN=Fadd PE=1 SV=1 PF01335//PF00531 Death effector domain//Death domain GO:0042981//GO:0007165 regulation of apoptotic process//signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.14886 BF_2 4.00 0.47 640 -- -- -- -- -- 764020144 NR_002819.3 640 0 Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14887 BF_2 2.00 0.45 474 -- -- -- -- -- 764020144 NR_002819.3 474 0 Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14889 BF_2 61.32 1.73 1768 801399331 XP_012060168.1 152 2.7e-07 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1489 BF_2 2.00 1.31 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14895 BF_2 127.00 2.54 2375 642920387 XP_008192325.1 296 7.3e-24 PREDICTED: uncharacterized protein LOC103312720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04690 YABBY protein GO:0007275 multicellular organismal development -- -- -- -- -- -- Cluster-8309.14899 BF_2 105.00 2.84 1835 91089769 XP_967094.1 1240 1.9e-133 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 654 7.2e-67 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.149 BF_2 14.01 0.66 1170 642912988 XP_008201341.1 175 3.9e-10 PREDICTED: uncharacterized protein LOC103315160 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14901 BF_2 331.26 7.42 2154 642928781 XP_008195560.1 1027 1.1e-108 PREDICTED: uncharacterized protein LOC654941 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75475 193 2.4e-13 PC4 and SFRS1-interacting protein OS=Homo sapiens GN=PSIP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1904 Transcription coactivator Cluster-8309.14902 BF_2 6.00 0.85 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14903 BF_2 110.15 11.82 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14905 BF_2 12.00 1.20 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14908 BF_2 178.47 12.90 866 642931457 XP_966478.2 520 2.8e-50 PREDICTED: ADP-ribosylation factor-like protein 6-interacting protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH07 151 7.1e-09 ADP-ribosylation factor-like protein 6-interacting protein 6 OS=Mus musculus GN=Arl6ip6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14909 BF_2 9.53 1.03 673 642931457 XP_966478.2 299 9.3e-25 PREDICTED: ADP-ribosylation factor-like protein 6-interacting protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14916 BF_2 172.00 4.30 1959 642912037 XP_008199068.1 277 9.6e-22 PREDICTED: uncharacterized protein LOC103314522 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07955 Protein of unknown function (DUF1687) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0005739 mitochondrion -- -- Cluster-8309.14922 BF_2 13.00 0.62 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14926 BF_2 19.66 0.99 1122 478253294 ENN73663.1 328 6.7e-28 hypothetical protein YQE_09740, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H3BPM6 142 1.0e-07 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14928 BF_2 46.16 0.45 4533 642919931 XP_974732.3 1610 6.0e-176 PREDICTED: tetratricopeptide repeat protein 5-like [Tribolium castaneum]>gi|270005358|gb|EFA01806.1| hypothetical protein TcasGA2_TC007407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BK48 883 4.9e-93 Tetratricopeptide repeat protein 5 OS=Rattus norvegicus GN=Ttc5 PE=2 SV=1 PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14929 BF_2 110.39 1.08 4557 642919931 XP_974732.3 1610 6.0e-176 PREDICTED: tetratricopeptide repeat protein 5-like [Tribolium castaneum]>gi|270005358|gb|EFA01806.1| hypothetical protein TcasGA2_TC007407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BK48 883 5.0e-93 Tetratricopeptide repeat protein 5 OS=Rattus norvegicus GN=Ttc5 PE=2 SV=1 PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.14931 BF_2 3.00 3.32 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14934 BF_2 69.00 1.57 2127 91092326 XP_970342.1 1999 2.2e-221 PREDICTED: NAD-dependent protein deacetylase sirtuin-7 [Tribolium castaneum]>gi|270015701|gb|EFA12149.1| hypothetical protein TcasGA2_TC002298 [Tribolium castaneum] -- -- -- -- -- K11417 SIRT7, SIR2L7 NAD-dependent deacetylase sirtuin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11417 Q9VAQ1 1120 7.6e-121 NAD-dependent protein deacetylase Sirt7 OS=Drosophila melanogaster GN=Sirt7 PE=1 SV=2 PF02146//PF02263 Sir2 family//Guanylate-binding protein, N-terminal domain -- -- GO:0005525//GO:0070403//GO:0003924 GTP binding//NAD+ binding//GTPase activity -- -- KOG1905 Class IV sirtuins (SIR2 family) Cluster-8309.14945 BF_2 24.34 0.92 1397 332372726 AEE61505.1 843 1.6e-87 unknown [Dendroctonus ponderosae]>gi|546679246|gb|ERL89740.1| hypothetical protein D910_07101 [Dendroctonus ponderosae] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 503 1.8e-49 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF13174//PF02465//PF13181//PF13414//PF04658//PF13176//PF07497//PF00515//PF13371 Tetratricopeptide repeat//Flagellar hook-associated protein 2 N-terminus//Tetratricopeptide repeat//TPR repeat//TAFII55 protein conserved region//Tetratricopeptide repeat//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006353//GO:0006367 DNA-templated transcription, termination//transcription initiation from RNA polymerase II promoter GO:0003723//GO:0005515 RNA binding//protein binding GO:0009424//GO:0005669 bacterial-type flagellum hook//transcription factor TFIID complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.14953 BF_2 150.00 7.19 1160 642929851 XP_008196001.1 185 2.7e-11 PREDICTED: uncharacterized protein LOC100142022 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF13965//PF07821 Oxaloacetate decarboxylase, gamma chain//dsRNA-gated channel SID-1//Alpha-amylase C-terminal beta-sheet domain GO:0005982//GO:0005985//GO:0006560//GO:0006814//GO:0071436//GO:0006090//GO:0033227//GO:0005975//GO:0006525//GO:0015931 starch metabolic process//sucrose metabolic process//proline metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process//dsRNA transport//carbohydrate metabolic process//arginine metabolic process//nucleobase-containing compound transport GO:0005509//GO:0051033//GO:0004556//GO:0015081//GO:0008948 calcium ion binding//RNA transmembrane transporter activity//alpha-amylase activity//sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.14961 BF_2 3.00 1.57 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14968 BF_2 35.81 0.36 4486 91076588 XP_968186.1 1366 1.2e-147 PREDICTED: transmembrane protein 194A [Tribolium castaneum]>gi|270002381|gb|EEZ98828.1| hypothetical protein TcasGA2_TC004435 [Tribolium castaneum] 642912650 XM_963240.2 181 4.9214e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K12198 CHMP5, VPS60 charged multivesicular body protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12198 Q9VVI9 706 1.6e-72 Charged multivesicular body protein 5 OS=Drosophila melanogaster GN=Vps60 PE=1 SV=2 PF04632//PF04111//PF16326//PF05531//PF01920//PF04871//PF03357//PF02252//PF00091//PF00462//PF07544 Fusaric acid resistance protein family//Autophagy protein Apg6//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//Uso1 / p115 like vesicle tethering protein, C terminal region//Snf7//Proteasome activator pa28 beta subunit//Tubulin/FtsZ family, GTPase domain//Glutaredoxin//RNA polymerase II transcription mediator complex subunit 9 GO:0006118//GO:0006357//GO:0007034//GO:0015031//GO:0006914//GO:0006810//GO:0006886//GO:0045454//GO:0006457 obsolete electron transport//regulation of transcription from RNA polymerase II promoter//vacuolar transport//protein transport//autophagy//transport//intracellular protein transport//cell redox homeostasis//protein folding GO:0051082//GO:0008565//GO:0003924//GO:0009055//GO:0015035//GO:0001104//GO:0003677 unfolded protein binding//protein transporter activity//GTPase activity//electron carrier activity//protein disulfide oxidoreductase activity//RNA polymerase II transcription cofactor activity//DNA binding GO:0016272//GO:0005737//GO:0019028//GO:0008537//GO:0016020//GO:0016592//GO:0005886 prefoldin complex//cytoplasm//viral capsid//proteasome activator complex//membrane//mediator complex//plasma membrane KOG1655 Protein involved in vacuolar protein sorting Cluster-8309.14972 BF_2 67.60 2.54 1400 478251660 ENN72114.1 644 1.9e-64 hypothetical protein YQE_11173, partial [Dendroctonus ponderosae]>gi|478262747|gb|ENN81278.1| hypothetical protein YQE_02314, partial [Dendroctonus ponderosae]>gi|546680914|gb|ERL91088.1| hypothetical protein D910_08430 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VMA0 249 5.0e-20 Non-structural maintenance of chromosomes element 1 homolog OS=Drosophila melanogaster GN=CG11329 PE=1 SV=1 PF09494//PF00130//PF13639//PF12678//PF12861//PF07574 Slx4 endonuclease//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ring finger domain//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//Nse1 non-SMC component of SMC5-6 complex GO:0006260//GO:0035556//GO:0006308//GO:0006281//GO:0016567 DNA replication//intracellular signal transduction//DNA catabolic process//DNA repair//protein ubiquitination GO:0008270//GO:0005515//GO:0017108//GO:0004842 zinc ion binding//protein binding//5'-flap endonuclease activity//ubiquitin-protein transferase activity GO:0033557//GO:0030915//GO:0005634//GO:0005680 Slx1-Slx4 complex//Smc5-Smc6 complex//nucleus//anaphase-promoting complex -- -- Cluster-8309.14974 BF_2 20.89 0.35 2804 642929061 XP_008195675.1 411 4.0e-37 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14975 BF_2 207.45 1.48 6134 642929059 XP_008195674.1 2113 3.8e-234 PREDICTED: A-agglutinin anchorage subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S0 859 4.1e-90 MTSS1-like protein OS=Mus musculus GN=Mtss1l PE=1 SV=1 PF14980//PF02205//PF08397 TIP39 peptide//WH2 motif//IRSp53/MIM homology domain GO:0007218//GO:0007009 neuropeptide signaling pathway//plasma membrane organization GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.14976 BF_2 61.58 4.08 919 642930190 XP_008196293.1 167 2.6e-09 PREDICTED: uncharacterized protein LOC103313824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14978 BF_2 6.00 6.89 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1498 BF_2 81.00 1.65 2337 642922875 XP_008200434.1 935 5.8e-98 PREDICTED: uncharacterized protein LOC103314918 [Tribolium castaneum]>gi|270006561|gb|EFA03009.1| hypothetical protein TcasGA2_TC010432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8K0R7 132 3.1e-06 Zinc finger protein 839 OS=Homo sapiens GN=ZNF839 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.14982 BF_2 75.00 3.01 1330 642936215 XP_008198351.1 1428 2.2e-155 PREDICTED: diuretic hormone receptor-like isoform X4 [Tribolium castaneum] 158294218 XM_315466.4 68 9.38618e-25 Anopheles gambiae str. PEST AGAP005464-PA (GPRDIH1) mRNA, complete cds K04578 CRHR1 corticotropin releasing hormone receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04578 P35464 907 2.4e-96 Diuretic hormone receptor OS=Manduca sexta PE=2 SV=1 PF00002//PF02793 7 transmembrane receptor (Secretin family)//Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.14986 BF_2 4.00 1.16 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.14988 BF_2 45.32 0.69 3033 189235075 XP_966626.2 2795 0.0e+00 PREDICTED: sorting nexin-14-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5W7 985 4.9e-105 Sorting nexin-14 OS=Homo sapiens GN=SNX14 PE=1 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.14989 BF_2 66.24 2.58 1362 91094199 XP_971496.1 1166 5.5e-125 PREDICTED: probable DNA-directed RNA polymerase III subunit RPC6 [Tribolium castaneum]>gi|270011207|gb|EFA07655.1| hypothetical protein TcasGA2_TC030601 [Tribolium castaneum] -- -- -- -- -- K03025 RPC6, POLR3F DNA-directed RNA polymerase III subunit RPC6 http://www.genome.jp/dbget-bin/www_bget?ko:K03025 Q9VD25 724 4.1e-75 Probable DNA-directed RNA polymerase III subunit RPC6 OS=Drosophila melanogaster GN=CG5380 PE=2 SV=1 PF05158 RNA polymerase Rpc34 subunit GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3233 RNA polymerase III, subunit C34 Cluster-8309.14994 BF_2 63.80 1.97 1640 478252125 ENN72556.1 881 7.4e-92 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 299 9.3e-26 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.14995 BF_2 9.00 0.66 854 391331686 XP_003740274.1 1083 1.5e-115 PREDICTED: 40S ribosomal protein S4-like [Metaseiulus occidentalis] -- -- -- -- -- K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4PMB3 1078 2.3e-116 40S ribosomal protein S4 OS=Ixodes scapularis GN=RpS4 PE=2 SV=1 PF00139//PF01479 Legume lectin domain//S4 domain -- -- GO:0003723//GO:0030246 RNA binding//carbohydrate binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.15 BF_2 7.00 2.06 429 533174851 XP_005400816.1 520 1.4e-50 PREDICTED: 60S ribosomal protein L31 [Chinchilla lanigera] 153252117 NM_000993.4 429 0 Homo sapiens ribosomal protein L31 (RPL31), transcript variant 1, mRNA K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 P62899 514 2.9e-51 60S ribosomal protein L31 OS=Homo sapiens GN=RPL31 PE=1 SV=1 PF01198//PF03852 Ribosomal protein L31e//DNA mismatch endonuclease Vsr GO:0006298//GO:0042254//GO:0006412 mismatch repair//ribosome biogenesis//translation GO:0004519//GO:0003735 endonuclease activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0893 60S ribosomal protein L31 Cluster-8309.15003 BF_2 155.00 2.54 2843 332373404 AEE61843.1 1354 1.8e-146 unknown [Dendroctonus ponderosae] 442615894 NM_132446.4 93 2.57574e-38 Drosophila melanogaster CG42339 (CG42339), transcript variant B, mRNA -- -- -- -- Q3UPR9 349 2.6e-31 Somatomedin-B and thrombospondin type-1 domain-containing protein OS=Mus musculus GN=Sbspon PE=2 SV=1 PF01033 Somatomedin B domain GO:0006955//GO:0007165 immune response//signal transduction GO:0030247//GO:0005044 polysaccharide binding//scavenger receptor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.15005 BF_2 10.00 1.39 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15012 BF_2 126.00 14.85 642 332376659 AEE63469.1 653 8.0e-66 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17404 MRPS25 small subunit ribosomal protein S25 http://www.genome.jp/dbget-bin/www_bget?ko:K17404 Q9VY28 585 2.5e-59 Probable 28S ribosomal protein S25, mitochondrial OS=Drosophila melanogaster GN=mRpS25 PE=1 SV=1 PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- KOG4079 Putative mitochondrial ribosomal protein mRpS25 Cluster-8309.15014 BF_2 78.00 2.99 1380 189236435 XP_001814418.1 186 2.4e-11 PREDICTED: uncharacterized protein LOC100142298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02234 Cyclin-dependent kinase inhibitor GO:0045859//GO:0007050 regulation of protein kinase activity//cell cycle arrest GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634 nucleus -- -- Cluster-8309.15015 BF_2 293.38 14.74 1120 91079734 XP_970112.1 1146 9.4e-123 PREDICTED: eukaryotic translation initiation factor 6 [Tribolium castaneum]>gi|270003327|gb|EEZ99774.1| hypothetical protein TcasGA2_TC002553 [Tribolium castaneum] -- -- -- -- -- K03264 EIF6 translation initiation factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03264 Q6GR45 1040 7.6e-112 Eukaryotic translation initiation factor 6 OS=Xenopus laevis GN=eif6 PE=2 SV=1 PF01912 eIF-6 family GO:0006413//GO:0042273//GO:0006446//GO:0042256 translational initiation//ribosomal large subunit biogenesis//regulation of translational initiation//mature ribosome assembly GO:0043023//GO:0003743//GO:0043022 ribosomal large subunit binding//translation initiation factor activity//ribosome binding GO:0005737//GO:0005730//GO:0005840 cytoplasm//nucleolus//ribosome KOG3185 Translation initiation factor 6 (eIF-6) Cluster-8309.15019 BF_2 2.00 0.33 543 646714568 KDR18481.1 545 2.2e-53 hypothetical protein L798_07670, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q95RI5 467 1.0e-45 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15020 BF_2 60.48 1.69 1783 478249775 ENN70283.1 1118 2.7e-119 hypothetical protein YQE_13066, partial [Dendroctonus ponderosae] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8NBN7 745 2.0e-77 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- -- -- Cluster-8309.15022 BF_2 76.58 2.26 1707 546678624 ERL89206.1 602 1.7e-59 hypothetical protein D910_06580 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15026 BF_2 11.00 0.82 848 391332028 XP_003740440.1 1105 4.1e-118 PREDICTED: 60S ribosomal protein L8-like [Metaseiulus occidentalis] 70909644 AM049009.1 151 4.28089e-71 Georissus sp. APV-2005 mRNA for ribosomal protein L8e (rpL8e gene) K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q9U9L2 1073 8.6e-116 60S ribosomal protein L8 OS=Anopheles gambiae GN=RpL8 PE=2 SV=2 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2309 60s ribosomal protein L2/L8 Cluster-8309.15027 BF_2 10.01 0.37 1434 828202126 XP_012555497.1 208 7.1e-14 PREDICTED: receptor-type tyrosine-protein phosphatase epsilon-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016020 membrane -- -- Cluster-8309.15028 BF_2 42.21 1.11 1878 225543488 NP_001139390.1 854 1.1e-88 phospholipase A2B precursor [Tribolium castaneum]>gi|224383699|gb|ACN42748.1| phospholipase A2B [Tribolium castaneum]>gi|270011520|gb|EFA07968.1| hypothetical protein TcasGA2_TC005550 [Tribolium castaneum] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P16354 239 9.7e-19 Phospholipase A2 isozymes PA3A/PA3B/PA5 OS=Heloderma suspectum PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15032 BF_2 19.00 3.26 531 746834577 XP_011067946.1 387 4.6e-35 PREDICTED: uncharacterized protein LOC105154263 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q9NBX5 148 9.7e-09 Nucleic-acid-binding protein from transposon X-element OS=Drosophila melanogaster GN=ORF1 PE=3 SV=1 PF02005 N2,N2-dimethylguanosine tRNA methyltransferase GO:0009451//GO:0008033 RNA modification//tRNA processing GO:0003723//GO:0004809 RNA binding//tRNA (guanine-N2-)-methyltransferase activity -- -- -- -- Cluster-8309.15038 BF_2 35.00 3.41 716 167444204 ABZ80663.1 352 7.1e-31 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.15050 BF_2 1.00 0.65 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15053 BF_2 27.37 0.41 3057 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02088 Ornatin GO:0007155//GO:0030193 cell adhesion//regulation of blood coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.15055 BF_2 86.64 0.90 4315 189234308 XP_971839.2 2048 9.3e-227 PREDICTED: solute carrier family 35 member F3 [Tribolium castaneum] -- -- -- -- -- K15288 SLC35F3_4 solute carrier family 35, member F3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15288 Q1LZI2 549 2.5e-54 Putative thiamine transporter SLC35F3 OS=Mus musculus GN=Slc35f3 PE=2 SV=1 PF00892//PF06027 EamA-like transporter family//Solute carrier family 35 GO:0006810 transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4314 Predicted carbohydrate/phosphate translocator Cluster-8309.15058 BF_2 98.81 3.99 1322 91084177 XP_966649.1 1219 3.8e-131 PREDICTED: GPN-loop GTPase 1 [Tribolium castaneum]>gi|270008775|gb|EFA05223.1| hypothetical protein TcasGA2_TC015364 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9HCN4 889 2.9e-94 GPN-loop GTPase 1 OS=Homo sapiens GN=GPN1 PE=1 SV=1 PF01926//PF01443//PF08477//PF00025//PF02421//PF06414//PF01637//PF03193//PF10662//PF00071//PF00931 50S ribosome-binding GTPase//Viral (Superfamily 1) RNA helicase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B//Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//Ethanolamine utilisation - propanediol utilisation//Ras family//NB-ARC domain GO:0006576//GO:0007264//GO:0015684 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005524//GO:0015093//GO:0043531//GO:0003924//GO:0000166//GO:0005525//GO:0016301 ATP binding//ferrous iron transmembrane transporter activity//ADP binding//GTPase activity//nucleotide binding//GTP binding//kinase activity GO:0016021 integral component of membrane KOG1532 GTPase XAB1, interacts with DNA repair protein XPA Cluster-8309.15062 BF_2 94.00 1.27 3382 642929376 XP_008195810.1 1360 4.4e-147 PREDICTED: condensin complex subunit 3-like [Tribolium castaneum]>gi|270010519|gb|EFA06967.1| hypothetical protein TcasGA2_TC009926 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YHB5 689 1.2e-70 Condensin complex subunit 3 OS=Xenopus laevis GN=ncapg PE=1 SV=1 PF02985//PF02151//PF16048//PF00514 HEAT repeat//UvrB/uvrC motif//Frog antimicrobial peptide//Armadillo/beta-catenin-like repeat GO:0006952 defense response GO:0005515 protein binding GO:0005576 extracellular region KOG2025 Chromosome condensation complex Condensin, subunit G Cluster-8309.15063 BF_2 9.00 0.32 1474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15065 BF_2 55.00 0.57 4314 478255001 ENN75234.1 2758 4.4e-309 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P91660 1080 6.7e-116 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF00004//PF01443//PF00664//PF01926//PF00158//PF13304//PF00931//PF02565//PF01637//PF02367//PF06414//PF00005//PF03193 Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Viral (Superfamily 1) RNA helicase//ABC transporter transmembrane region//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//NB-ARC domain//Recombination protein O C terminal//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006310//GO:0002949//GO:0006355//GO:0006281//GO:0006810//GO:0055085 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair//transport//transmembrane transport GO:0005525//GO:0043531//GO:0042626//GO:0016887//GO:0016301//GO:0008134//GO:0003924//GO:0005524 GTP binding//ADP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//transcription factor binding//GTPase activity//ATP binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.15073 BF_2 216.35 2.10 4595 642922752 XP_008193309.1 474 3.2e-44 PREDICTED: uncharacterized protein LOC103312998 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00003//PF02979//PF00514//PF02600//PF00552 7 transmembrane sweet-taste receptor of 3 GCPR//Nitrile hydratase, alpha chain//Armadillo/beta-catenin-like repeat//Disulfide bond formation protein DsbB//Integrase DNA binding domain GO:0006807//GO:0007186//GO:0006118 nitrogen compound metabolic process//G-protein coupled receptor signaling pathway//obsolete electron transport GO:0015035//GO:0003676//GO:0005515//GO:0004930//GO:0046914//GO:0003824 protein disulfide oxidoreductase activity//nucleic acid binding//protein binding//G-protein coupled receptor activity//transition metal ion binding//catalytic activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.15074 BF_2 21.78 0.71 1577 478255900 ENN76104.1 913 1.4e-95 hypothetical protein YQE_07364, partial [Dendroctonus ponderosae] -- -- -- -- -- K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 Q75WV3 294 3.4e-25 Probable trehalose-phosphate phosphatase 1 OS=Oryza sativa subsp. japonica GN=TPP1 PE=1 SV=1 PF02358//PF03310 Trehalose-phosphatase//Caulimovirus DNA-binding protein GO:0005992 trehalose biosynthetic process GO:0003677//GO:0003824 DNA binding//catalytic activity -- -- -- -- Cluster-8309.15075 BF_2 329.22 11.19 1518 478255900 ENN76104.1 913 1.3e-95 hypothetical protein YQE_07364, partial [Dendroctonus ponderosae] -- -- -- -- -- K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 Q75WV3 294 3.3e-25 Probable trehalose-phosphate phosphatase 1 OS=Oryza sativa subsp. japonica GN=TPP1 PE=1 SV=1 PF03310//PF02358 Caulimovirus DNA-binding protein//Trehalose-phosphatase GO:0005992 trehalose biosynthetic process GO:0003824//GO:0003677 catalytic activity//DNA binding -- -- -- -- Cluster-8309.15078 BF_2 8.04 0.94 645 91091818 XP_966528.1 281 1.1e-22 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 Q60934 207 1.7e-15 Glutamate receptor ionotropic, kainate 1 OS=Mus musculus GN=Grik1 PE=2 SV=2 PF00060 Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005216//GO:0004970 ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.15080 BF_2 11.00 1.81 542 113951691 NP_001039280.1 410 1.0e-37 chemosensory protein 12 precursor [Tribolium castaneum]>gi|112031836|gb|ABH88185.1| chemosensory protein 12 [Tribolium castaneum]>gi|270010974|gb|EFA07422.1| chemosensory protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W1C9 321 8.7e-29 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15082 BF_2 65.44 1.37 2287 189241122 XP_001812931.1 721 3.7e-73 PREDICTED: protein saal1 [Tribolium castaneum]>gi|270013331|gb|EFA09779.1| hypothetical protein TcasGA2_TC011921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q803M5 199 5.1e-14 Protein saal1 OS=Danio rerio GN=saal1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15084 BF_2 116.82 2.24 2470 642924858 XP_008194069.1 1120 2.2e-119 PREDICTED: uncharacterized protein LOC103313199 [Tribolium castaneum]>gi|270006682|gb|EFA03130.1| hypothetical protein TcasGA2_TC013041 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04333//PF00168 MlaA lipoprotein//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.15087 BF_2 1.83 0.52 434 646719707 KDR21725.1 488 7.3e-47 putative E3 ubiquitin-protein ligase MYCBP2, partial [Zootermopsis nevadensis] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 Q7TPH6 394 2.4e-37 E3 ubiquitin-protein ligase MYCBP2 OS=Mus musculus GN=Mycbp2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15090 BF_2 115.00 15.52 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15091 BF_2 117.00 3.27 1786 642932770 XP_008196976.1 796 5.8e-82 PREDICTED: uncharacterized protein LOC103314031 [Tribolium castaneum]>gi|270012451|gb|EFA08899.1| hypothetical protein TcasGA2_TC006600 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145 Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development -- -- GO:0005634 nucleus -- -- Cluster-8309.15092 BF_2 30.00 1.93 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15093 BF_2 15.00 0.88 997 115443581 YP_778600.1 155 6.9e-08 Ycf3 protein [Bigelowiella natans]>gi|122233785|sp|Q06J27.1|YCF3_BIGNA RecName: Full=Photosystem I assembly protein Ycf3>gi|110810226|gb|ABG91432.1| Ycf3 protein [Bigelowiella natans] 761231605 KM881639.1 994 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P58257 277 2.0e-23 Photosystem I assembly protein Ycf3 OS=Triticum aestivum GN=ycf3 PE=3 SV=2 -- -- -- -- -- -- GO:0009536 plastid -- -- Cluster-8309.15094 BF_2 16.15 0.68 1274 755875739 XP_011292600.1 155 8.8e-08 PREDICTED: longitudinals lacking protein, isoforms H/M/V-like isoform X4 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05495//PF00096 CHY zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.15098 BF_2 34.49 0.55 2912 91088445 XP_968690.1 1260 1.5e-135 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 857 3.3e-90 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF00515//PF07497//PF13371//PF13176//PF04658//PF00520//PF13414//PF13181//PF04564//PF02465 Tetratricopeptide repeat//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TAFII55 protein conserved region//Ion transport protein//TPR repeat//Tetratricopeptide repeat//U-box domain//Flagellar hook-associated protein 2 N-terminus GO:0016567//GO:0055085//GO:0006367//GO:0006811//GO:0006353 protein ubiquitination//transmembrane transport//transcription initiation from RNA polymerase II promoter//ion transport//DNA-templated transcription, termination GO:0004842//GO:0005515//GO:0003723//GO:0005216 ubiquitin-protein transferase activity//protein binding//RNA binding//ion channel activity GO:0000151//GO:0005669//GO:0009424//GO:0016020 ubiquitin ligase complex//transcription factor TFIID complex//bacterial-type flagellum hook//membrane KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.15100 BF_2 10.00 0.55 1049 -- -- -- -- -- 697072656 XM_009652837.1 579 0 Verticillium dahliae VdLs.17 hypothetical protein partial mRNA -- -- -- -- Q01589 166 1.6e-10 Cell wall protein SED1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SED1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15106 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12899 Alkaline and neutral invertase -- -- GO:0033926 glycopeptide alpha-N-acetylgalactosaminidase activity -- -- -- -- Cluster-8309.15107 BF_2 6.00 0.94 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15109 BF_2 0.57 0.31 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15112 BF_2 31.08 1.36 1241 817080904 XP_012262936.1 403 1.5e-36 PREDICTED: uncharacterized protein LOC105690035 [Athalia rosae] 751199911 XM_011161007.1 106 6.56875e-46 PREDICTED: Solenopsis invicta uncharacterized LOC105195552 (LOC105195552), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15115 BF_2 4.00 0.58 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15117 BF_2 77.82 3.18 1312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03839 Translocation protein Sec62 GO:0015031 protein transport GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.15118 BF_2 54.76 3.44 953 91076370 XP_967715.1 1040 1.6e-110 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] 752877090 XR_889181.1 40 2.44785e-09 PREDICTED: Camponotus floridanus ras-related protein Rab-8A (LOC105251123), transcript variant X2, misc_RNA K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 Q4LE85 742 2.3e-77 Ras-related protein Rab-27A OS=Sus scrofa GN=RAB27A PE=2 SV=1 PF00025//PF00071//PF08477//PF03193//PF01926 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0093 GTPase Rab3, small G protein superfamily Cluster-8309.15119 BF_2 44.00 1.97 1222 258645094 NP_001158260.1 1001 6.7e-106 grain [Tribolium castaneum] 258645093 NM_001164788.1 348 1.921e-180 Tribolium castaneum grain (Grn), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 Q91428 223 4.5e-17 Transcription factor GATA-3 OS=Danio rerio GN=gata3 PE=2 SV=1 PF00297//PF08273//PF00320 Ribosomal protein L3//Zinc-binding domain of primase-helicase//GATA zinc finger GO:0042254//GO:0006269//GO:0006355//GO:0006412//GO:0006351 ribosome biogenesis//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//translation//transcription, DNA-templated GO:0003896//GO:0003700//GO:0043565//GO:0003735//GO:0008270//GO:0004386 DNA primase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//structural constituent of ribosome//zinc ion binding//helicase activity GO:0005730//GO:0005622//GO:0005840//GO:0005667//GO:0005657 nucleolus//intracellular//ribosome//transcription factor complex//replication fork KOG1601 GATA-4/5/6 transcription factors Cluster-8309.15120 BF_2 79.00 1.86 2061 768438692 XP_011560942.1 429 2.4e-39 PREDICTED: GATA-binding factor C-like isoform X2 [Plutella xylostella] 241998887 XM_002434042.1 139 4.99087e-64 Ixodes scapularis endothelial transcription factor GATA-2, putative, mRNA K17894 GATA2 GATA-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17894 P91623 404 7.8e-38 GATA-binding factor C OS=Drosophila melanogaster GN=grn PE=2 SV=1 PF00320//PF01873 GATA zinc finger//Domain found in IF2B/IF5 GO:0006446//GO:0006355//GO:0006413 regulation of translational initiation//regulation of transcription, DNA-templated//translational initiation GO:0003743//GO:0003700//GO:0008270//GO:0043565 translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005840 transcription factor complex//ribosome KOG1601 GATA-4/5/6 transcription factors Cluster-8309.15123 BF_2 8.81 0.50 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15126 BF_2 61.74 1.13 2569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15128 BF_2 119.16 5.85 1139 91087501 XP_968536.1 586 8.3e-58 PREDICTED: DNA replication complex GINS protein PSF3 [Tribolium castaneum]>gi|270010665|gb|EFA07113.1| hypothetical protein TcasGA2_TC010104 [Tribolium castaneum] -- -- -- -- -- K10734 GINS3 GINS complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10734 Q5RDV0 241 3.4e-19 DNA replication complex GINS protein PSF3 OS=Pongo abelii GN=GINS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15130 BF_2 26.00 0.93 1460 123227460 CAM27169.1 247 2.2e-18 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] -- -- -- -- -- K09210 KLF15 krueppel-like factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09210 Q5VIY5 241 4.4e-19 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.15135 BF_2 7.00 0.78 661 -- -- -- -- -- 642936890 XR_511484.1 53 9.91008e-17 PREDICTED: Tribolium castaneum tropomodulin (LOC658846), transcript variant X2, misc_RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15138 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15141 BF_2 15.00 0.98 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15144 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15145 BF_2 99.00 1.69 2742 546685658 ERL95124.1 1069 2.0e-113 hypothetical protein D910_12394, partial [Dendroctonus ponderosae] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 A0FI79 422 8.5e-40 72 kDa inositol polyphosphate 5-phosphatase OS=Pan troglodytes GN=INPP5E PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.15147 BF_2 12.61 0.32 1950 91083015 XP_974607.1 216 1.1e-14 PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|642923430|ref|XP_008193741.1| PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|270007020|gb|EFA03468.1| hypothetical protein TcasGA2_TC013464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07730 Histidine kinase GO:0000160//GO:0016310 phosphorelay signal transduction system//phosphorylation GO:0000155//GO:0046983 phosphorelay sensor kinase activity//protein dimerization activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex -- -- Cluster-8309.15151 BF_2 625.32 13.42 2237 91094333 XP_969230.1 955 2.7e-100 PREDICTED: acyl-protein thioesterase 1 [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 Q5RBR7 628 9.0e-64 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF01764//PF00326//PF05577//PF02230//PF10503//PF07859//PF01738 Lipase (class 3)//Prolyl oligopeptidase family//Serine carboxypeptidase S28//Phospholipase/Carboxylesterase//Esterase PHB depolymerase//alpha/beta hydrolase fold//Dienelactone hydrolase family GO:0006629//GO:0006508//GO:0008152 lipid metabolic process//proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity GO:0005576 extracellular region KOG2112 Lysophospholipase Cluster-8309.15157 BF_2 11.61 0.57 1146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1516 BF_2 49.47 1.52 1652 546676649 ERL87613.1 434 5.1e-40 hypothetical protein D910_05004 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15160 BF_2 87.00 5.96 898 332168659 AEE25770.1 1388 6.6e-151 chymotrypsin [Scylla paramamosain] 332168658 JF831535.1 895 0 Scylla paramamosain chymotrypsin mRNA, complete cds K01311 CTRC chymotrypsin C http://www.genome.jp/dbget-bin/www_bget?ko:K01311 Q00871 1149 1.4e-124 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.15168 BF_2 3.00 0.70 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06387//PF09064//PF03504 D1 dopamine receptor-interacting protein (calcyon)//Thrombomodulin like fifth domain, EGF-like//Chlamydia cysteine-rich outer membrane protein 6 GO:0048268//GO:0007212//GO:0007165 clathrin coat assembly//dopamine receptor signaling pathway//signal transduction GO:0005201//GO:0004888//GO:0032051 extracellular matrix structural constituent//transmembrane signaling receptor activity//clathrin light chain binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane -- -- Cluster-8309.15175 BF_2 170.32 1.04 7169 642919044 XP_008191710.1 2033 8.5e-225 PREDICTED: neurotactin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23654 1323 7.4e-144 Neurotactin OS=Drosophila melanogaster GN=Nrt PE=1 SV=3 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.15183 BF_2 5.00 0.68 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15188 BF_2 9.00 1.96 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1519 BF_2 37.00 3.65 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15190 BF_2 55.98 2.36 1280 642924004 XP_008193965.1 1014 2.2e-107 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 376 8.6e-35 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF03275//PF00400 UDP-galactopyranose mutase//WD domain, G-beta repeat -- -- GO:0008767//GO:0005515 UDP-galactopyranose mutase activity//protein binding -- -- KOG1188 WD40 repeat protein Cluster-8309.15192 BF_2 8.66 0.45 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15198 BF_2 14.44 0.36 1946 602672006 XP_007441513.1 624 5.6e-62 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like isoform X1 [Python bivittatus] 356640774 JN597285.1 672 0 Anastrepha suspensa transformer female-specific transcript variant and truncated transformer male-specific transcript (tra) gene, complete cds, alternatively spliced -- -- -- -- Q86UP8 382 2.6e-35 General transcription factor II-I repeat domain-containing protein 2A OS=Homo sapiens GN=GTF2IRD2 PE=1 SV=2 PF08302//PF10288 Fungal tRNA ligase phosphodiesterase domain//Cytoplasmic tRNA 2-thiolation protein 2 GO:0034227//GO:0006388//GO:0002098 tRNA thio-modification//tRNA splicing, via endonucleolytic cleavage and ligation//tRNA wobble uridine modification GO:0005524//GO:0000049//GO:0003972 ATP binding//tRNA binding//RNA ligase (ATP) activity -- -- -- -- Cluster-8309.15199 BF_2 53.40 0.73 3345 642940098 XP_008192969.1 1039 7.2e-110 PREDICTED: excitatory amino acid transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q25605 463 1.8e-44 Excitatory amino acid transporter OS=Onchocerca volvulus GN=GLT-1 PE=2 SV=1 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006812//GO:0006835 anion transport//cation transport//dicarboxylic acid transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.15201 BF_2 3.00 56.39 218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15205 BF_2 248.85 6.84 1810 332376975 AEE63627.1 1501 1.0e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 3.38019e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 1.5e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF02984//PF01857//PF00382//PF04545 Cyclin, C-terminal domain//Retinoblastoma-associated protein B domain//Transcription factor TFIIB repeat//Sigma-70, region 4 GO:0051726//GO:0006355//GO:0006352 regulation of cell cycle//regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700//GO:0017025 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//TBP-class protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1597 Transcription initiation factor TFIIB Cluster-8309.15208 BF_2 5.12 1.07 487 478254758 ENN74995.1 310 3.6e-26 hypothetical protein YQE_08452, partial [Dendroctonus ponderosae] -- -- -- -- -- K03950 NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03950 Q02366 213 2.6e-16 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Bos taurus GN=NDUFA6 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3426 NADH:ubiquinone oxidoreductase, NDUFA6/B14 subunit Cluster-8309.15219 BF_2 60.25 0.74 3692 546681046 ERL91211.1 1248 4.6e-134 hypothetical protein D910_08549 [Dendroctonus ponderosae] -- -- -- -- -- K15119 SLC25A39_40 solute carrier family 25, member 39/40 http://www.genome.jp/dbget-bin/www_bget?ko:K15119 Q6DHC3 920 2.1e-97 Solute carrier family 25 member 40 OS=Danio rerio GN=slc25a40 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0761 Mitochondrial carrier protein CGI-69 Cluster-8309.15220 BF_2 249.01 3.06 3686 546681046 ERL91211.1 1248 4.6e-134 hypothetical protein D910_08549 [Dendroctonus ponderosae] -- -- -- -- -- K15119 SLC25A39_40 solute carrier family 25, member 39/40 http://www.genome.jp/dbget-bin/www_bget?ko:K15119 Q6DHC3 920 2.1e-97 Solute carrier family 25 member 40 OS=Danio rerio GN=slc25a40 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0761 Mitochondrial carrier protein CGI-69 Cluster-8309.15224 BF_2 81.74 0.86 4276 189235426 XP_001812566.1 2631 2.3e-294 PREDICTED: adenylate cyclase type 2-like [Tribolium castaneum] -- -- -- -- -- K08042 ADCY2 adenylate cyclase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08042 P40146 975 1.0e-103 Adenylate cyclase type 8 OS=Rattus norvegicus GN=Adcy8 PE=2 SV=1 PF00211//PF03248//PF06327 Adenylate and Guanylate cyclase catalytic domain//Rer1 family//Domain of Unknown Function (DUF1053) GO:0006171//GO:0006144//GO:0009190//GO:0035556 cAMP biosynthetic process//purine nucleobase metabolic process//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0004016//GO:0016849 adenylate cyclase activity//phosphorus-oxygen lyase activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.15227 BF_2 1.00 2.06 284 478256535 ENN76719.1 227 8.7e-17 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.15230 BF_2 12.00 0.84 883 375153528 AFA36654.1 498 1.0e-47 elongation factor 1-delta protein [Eriocheir sinensis] 375153527 JN638238.1 393 0 Eriocheir sinensis elongation factor 1-delta protein mRNA, complete cds K15410 EEF1D elongation factor 1-delta http://www.genome.jp/dbget-bin/www_bget?ko:K15410 P12262 434 1.1e-41 Elongation factor 1-beta OS=Artemia salina PE=1 SV=3 PF00736//PF04513//PF00170 EF-1 guanine nucleotide exchange domain//Baculovirus polyhedron envelope protein, PEP, C terminus//bZIP transcription factor GO:0006355//GO:0006414//GO:0006448 regulation of transcription, DNA-templated//translational elongation//regulation of translational elongation GO:0043565//GO:0003746//GO:0003700//GO:0005198 sequence-specific DNA binding//translation elongation factor activity//transcription factor activity, sequence-specific DNA binding//structural molecule activity GO:0005840//GO:0005853//GO:0019028//GO:0005667//GO:0019031 ribosome//eukaryotic translation elongation factor 1 complex//viral capsid//transcription factor complex//viral envelope KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.15232 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15238 BF_2 3.00 0.53 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1524 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15242 BF_2 39.60 0.81 2342 270014242 EFA10690.1 946 3.1e-99 aminopeptidase-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LQ0 630 5.5e-64 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.15246 BF_2 343.64 8.73 1934 91093659 XP_966349.1 2157 9.6e-240 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] 686775201 LM127048.1 46 2.33602e-12 Taenia asiatica genome assembly T_asiatica_South_Korea ,scaffold TASK_contig0000687 K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 Q9W3K5 1913 7.7e-213 Glutamate--cysteine ligase OS=Drosophila melanogaster GN=Gclc PE=2 SV=1 PF00355//PF03074 Rieske [2Fe-2S] domain//Glutamate-cysteine ligase GO:0055114//GO:0006750//GO:0006749 oxidation-reduction process//glutathione biosynthetic process//glutathione metabolic process GO:0016491//GO:0004357//GO:0051537 oxidoreductase activity//glutamate-cysteine ligase activity//2 iron, 2 sulfur cluster binding GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.15249 BF_2 4.61 0.40 764 478253294 ENN73663.1 335 7.1e-29 hypothetical protein YQE_09740, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H3BPM6 140 1.2e-07 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15259 BF_2 8.00 2.24 436 307208309 EFN85734.1 172 3.2e-10 Fatty acid synthase [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P12785 140 6.8e-08 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15260 BF_2 48.00 1.80 1401 484759900 YP_007890509.1 610 1.7e-60 ATP synthase F0 subunit a (mitochondrion) [Andalucia godoyi]>gi|462269131|gb|AGH24003.1| ATP synthase F0 subunit a (mitochondrion) [Andalucia godoyi] 528540458 AP012528.1 1350 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P68527 958 3.1e-102 ATP synthase subunit a OS=Triticum aestivum GN=ATP6 PE=3 SV=1 PF00119 ATP synthase A chain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG4665 ATP synthase F0 subunit 6 and related proteins Cluster-8309.15263 BF_2 194.06 3.75 2454 642910823 XP_008193424.1 1393 4.7e-151 PREDICTED: rab11 family-interacting protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 9.7e-27 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15264 BF_2 20.73 0.33 2907 189242442 XP_001807060.1 389 1.5e-34 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- K19599 DOME cytokine receptor domeless http://www.genome.jp/dbget-bin/www_bget?ko:K19599 -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15265 BF_2 16.65 0.55 1544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15267 BF_2 9.00 0.87 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05502//PF03554 Dynactin p62 family//UL73 viral envelope glycoprotein -- -- -- -- GO:0005869//GO:0019031 dynactin complex//viral envelope -- -- Cluster-8309.15270 BF_2 22.70 0.32 3227 557160153 CDJ27266.1 145 3.2e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.5e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15272 BF_2 7.24 0.43 988 91079458 XP_966537.1 486 2.8e-46 PREDICTED: SAP30-binding protein [Tribolium castaneum]>gi|270004398|gb|EFA00846.1| hypothetical protein TcasGA2_TC003747 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UHR5 214 4.0e-16 SAP30-binding protein OS=Homo sapiens GN=SAP30BP PE=1 SV=1 PF07818//PF05558 HCNGP-like protein//DREPP plasma membrane polypeptide GO:0006355//GO:0051716 regulation of transcription, DNA-templated//cellular response to stimulus -- -- GO:0046658 anchored component of plasma membrane -- -- Cluster-8309.15274 BF_2 157.99 2.58 2845 189235344 XP_975427.2 1802 2.1e-198 PREDICTED: transmembrane protein 135-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GQ39 547 2.8e-54 Transmembrane protein 135 OS=Xenopus laevis GN=tmem135 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1398 Uncharacterized conserved protein Cluster-8309.15275 BF_2 203.38 3.19 2950 189235344 XP_975427.2 1954 5.0e-216 PREDICTED: transmembrane protein 135-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4F4 587 6.8e-59 Transmembrane protein 135 OS=Rattus norvegicus GN=Tmem135 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1398 Uncharacterized conserved protein Cluster-8309.15276 BF_2 23.00 0.54 2085 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15277 BF_2 21.00 1.87 758 873233467 CEM03308.1 523 1.1e-50 unnamed protein product [Vitrella brassicaformis CCMP3155] 116634587 CT833858.1 755 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCSN007H14, full insert sequence K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q07661 793 2.2e-83 Nucleoside diphosphate kinase 1 OS=Oryza sativa subsp. japonica GN=NDKR PE=1 SV=1 PF00334//PF12605 Nucleoside diphosphate kinase//Casein kinase 1 gamma C terminal GO:0006241//GO:0006206//GO:0006165//GO:0006228//GO:0016310//GO:0009069//GO:0006144//GO:0006183 CTP biosynthetic process//pyrimidine nucleobase metabolic process//nucleoside diphosphate phosphorylation//UTP biosynthetic process//phosphorylation//serine family amino acid metabolic process//purine nucleobase metabolic process//GTP biosynthetic process GO:0004674//GO:0004550 protein serine/threonine kinase activity//nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.15278 BF_2 52.00 1805.79 205 -- -- -- -- -- 32487964 AL606444.3 196 8.78752e-97 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSJNBa0043L09, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15281 BF_2 43.23 0.92 2258 646696193 KDR08640.1 667 6.7e-67 hypothetical protein L798_01542 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08655 DASH complex subunit Ask1 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.15283 BF_2 86.76 1.95 2144 642935034 XP_008199914.1 150 5.6e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 8.27359e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF10186//PF03938//PF04111//PF05835//PF02841 Vacuolar sorting 38 and autophagy-related subunit 14//Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Synaphin protein//Guanylate-binding protein, C-terminal domain GO:0006836//GO:0006914//GO:0010508 neurotransmitter transport//autophagy//positive regulation of autophagy GO:0005525//GO:0051082//GO:0019905//GO:0003924 GTP binding//unfolded protein binding//syntaxin binding//GTPase activity -- -- -- -- Cluster-8309.15284 BF_2 15.53 0.34 2208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769//PF03603 Divalent cation transporter//DNA polymerase III psi subunit GO:0006812//GO:0006260 cation transport//DNA replication GO:0008324//GO:0008408//GO:0003887 cation transmembrane transporter activity//3'-5' exonuclease activity//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.15285 BF_2 3.00 0.46 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15287 BF_2 31.06 1.39 1222 642919373 XP_008191844.1 734 6.1e-75 PREDICTED: vascular endothelial growth factor receptor 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P35969 445 8.2e-43 Vascular endothelial growth factor receptor 1 OS=Mus musculus GN=Flt1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.15291 BF_2 46.35 0.75 2875 391335701 XP_003742228.1 618 4.1e-61 PREDICTED: uncharacterized protein LOC100899883 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15292 BF_2 30.00 0.52 2708 391335701 XP_003742228.1 618 3.8e-61 PREDICTED: uncharacterized protein LOC100899883 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15294 BF_2 21.54 0.35 2890 332376577 AEE63428.1 1040 4.8e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 550 1.3e-54 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722//PF11522 Peptidase C26//Yeast phosphatidylinositol-4-OH kinase Pik1 GO:0006541 glutamine metabolic process GO:0016773//GO:0016787 phosphotransferase activity, alcohol group as acceptor//hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.15295 BF_2 24.81 0.64 1914 270005690 EFA02138.1 363 1.0e-31 hypothetical protein TcasGA2_TC007788 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 209 3.0e-15 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 PF00895//PF02310 ATP synthase protein 8//B12 binding domain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0046872//GO:0031419//GO:0015078 metal ion binding//cobalamin binding//hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2882 p-Nitrophenyl phosphatase Cluster-8309.15296 BF_2 10.61 0.70 924 642929008 XP_008195652.1 745 2.5e-76 PREDICTED: mediator of RNA polymerase II transcription subunit 8 [Tribolium castaneum]>gi|270010446|gb|EFA06894.1| hypothetical protein TcasGA2_TC009839 [Tribolium castaneum] -- -- -- -- -- K15129 MED8 mediator of RNA polymerase II transcription subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K15129 A1ZBT5 466 2.3e-45 Mediator of RNA polymerase II transcription subunit 8 OS=Drosophila melanogaster GN=MED8 PE=2 SV=1 PF16969//PF10232 RNA-binding signal recognition particle 68//Mediator of RNA polymerase II transcription complex subunit 8 GO:0006357//GO:0006614 regulation of transcription from RNA polymerase II promoter//SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0005047//GO:0030942//GO:0001104 7S RNA binding//signal recognition particle binding//endoplasmic reticulum signal peptide binding//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005786 mediator complex//signal recognition particle, endoplasmic reticulum targeting KOG3583 Uncharacterized conserved protein Cluster-8309.15300 BF_2 6.00 0.66 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15301 BF_2 15.00 0.36 2009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15302 BF_2 5.00 0.76 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15305 BF_2 9.92 1.57 551 91084915 XP_970253.1 217 2.5e-15 PREDICTED: juvenile hormone esterase [Tribolium castaneum]>gi|270008560|gb|EFA05008.1| hypothetical protein TcasGA2_TC015089 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08171 128 2.1e-06 Esterase-6 OS=Drosophila melanogaster GN=Est-6 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.15314 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15317 BF_2 69.53 0.64 4823 646723340 KDR23974.1 697 4.7e-70 Stathmin [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q09002 147 1.2e-07 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF13741//PF00318//PF08496//PF06667//PF01544//PF01442//PF14372//PF08074//PF01956//PF02096//PF00836 Mitochondrial ribosomal protein S25//Ribosomal protein S2//Peptidase family S49 N-terminal//Phage shock protein B//CorA-like Mg2+ transporter protein//Apolipoprotein A1/A4/E domain//Domain of unknown function (DUF4413)//CHDCT2 (NUC038) domain//Integral membrane protein DUF106//60Kd inner membrane protein//Stathmin family GO:0042157//GO:0030001//GO:0006412//GO:0006869//GO:0031110//GO:0006355//GO:0042254//GO:0009271//GO:0055085//GO:0051205 lipoprotein metabolic process//metal ion transport//translation//lipid transport//regulation of microtubule polymerization or depolymerization//regulation of transcription, DNA-templated//ribosome biogenesis//phage shock//transmembrane transport//protein insertion into membrane GO:0046873//GO:0003677//GO:0008289//GO:0003735//GO:0008270//GO:0004252//GO:0016818//GO:0005524 metal ion transmembrane transporter activity//DNA binding//lipid binding//structural constituent of ribosome//zinc ion binding//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding GO:0016020//GO:0005576//GO:0005763//GO:0005886//GO:0005634//GO:0005622//GO:0005840//GO:0016021 membrane//extracellular region//mitochondrial small ribosomal subunit//plasma membrane//nucleus//intracellular//ribosome//integral component of membrane -- -- Cluster-8309.15326 BF_2 133.97 2.41 2616 91077384 XP_975249.1 1307 4.7e-141 PREDICTED: protoporphyrinogen oxidase [Tribolium castaneum]>gi|270001648|gb|EEZ98095.1| hypothetical protein TcasGA2_TC000508 [Tribolium castaneum] -- -- -- -- -- K00231 PPOX, hemY oxygen-dependent protoporphyrinogen oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00231 P51175 757 1.2e-78 Protoporphyrinogen oxidase OS=Mus musculus GN=Ppox PE=1 SV=1 PF03144//PF07992//PF02269//PF01266//PF00070//PF12831//PF01593 Elongation factor Tu domain 2//Pyridine nucleotide-disulphide oxidoreductase//Transcription initiation factor IID, 18kD subunit//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase GO:0008152//GO:0006366//GO:0055114 metabolic process//transcription from RNA polymerase II promoter//oxidation-reduction process GO:0005525//GO:0016491 GTP binding//oxidoreductase activity -- -- KOG3901 Transcription initiation factor IID subunit Cluster-8309.15327 BF_2 14.58 0.38 1884 478259144 ENN79064.1 470 3.9e-44 hypothetical protein YQE_04485, partial [Dendroctonus ponderosae] 195134144 XM_002011462.1 52 1.05077e-15 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q9VY99 380 4.3e-35 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF00246//PF04952 Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016788//GO:0008270//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//metallocarboxypeptidase activity -- -- KOG3641 Zinc carboxypeptidase Cluster-8309.15328 BF_2 2.00 0.38 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15329 BF_2 56.41 1.81 1593 642912555 XP_008200909.1 310 1.2e-25 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q8BSF4 184 2.0e-12 Phosphatidylserine decarboxylase proenzyme OS=Mus musculus GN=Pisd PE=2 SV=1 -- -- GO:0006566//GO:0006563//GO:0006544//GO:0008654//GO:0046486 threonine metabolic process//L-serine metabolic process//glycine metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.1533 BF_2 11.16 0.77 890 282158105 NP_001164096.1 368 1.2e-32 diuretic hormone 37 like protein [Tribolium castaneum]>gi|270016218|gb|EFA12664.1| diuretic hormone 37 like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00473 Corticotropin-releasing factor family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.15335 BF_2 2.00 2.25 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15337 BF_2 11.00 0.35 1619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15339 BF_2 5.73 0.42 857 642931629 XP_008196662.1 257 8.8e-20 PREDICTED: broad-complex core protein isoform 6-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF13912//PF02892//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.15341 BF_2 5.00 0.97 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15343 BF_2 7.00 0.89 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15344 BF_2 5.76 0.39 901 642912701 XP_970424.2 588 3.8e-58 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 170 4.7e-11 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.15350 BF_2 1.00 3.42 265 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15351 BF_2 153.63 2.22 3182 808861794 KKF13591.1 334 3.9e-28 Zinc finger protein 235 [Larimichthys crocea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q3ZCX4 316 1.9e-27 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF10389//PF13465//PF00096//PF06220//PF13912//PF05191//PF07776 Bacteriophage coat protein B//Zinc-finger double domain//Zinc finger, C2H2 type//U1 zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid//Zinc-finger associated domain (zf-AD) GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017//GO:0008270 metal ion binding//adenylate kinase activity//zinc ion binding GO:0019028//GO:0005634 viral capsid//nucleus -- -- Cluster-8309.15353 BF_2 32.46 0.46 3245 762094725 XP_011429851.1 308 4.1e-25 PREDICTED: zinc finger protein OZF-like [Crassostrea gigas] -- -- -- -- -- -- -- -- -- Q3ZCX4 289 2.7e-24 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF06220//PF00320//PF01844//PF13912//PF00096//PF07711//PF10389//PF13465//PF16622//PF05191//PF02085//PF02892//PF00412//PF00130//PF06467//PF07776 U1 zinc finger//GATA zinc finger//HNH endonuclease//C2H2-type zinc finger//Zinc finger, C2H2 type//Rab geranylgeranyl transferase alpha-subunit, insert domain//Bacteriophage coat protein B//Zinc-finger double domain//zinc-finger C2H2-type//Adenylate kinase, active site lid//Class III cytochrome C family//BED zinc finger//LIM domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD) GO:0006144//GO:0035556//GO:0006118//GO:0006355//GO:0046034 purine nucleobase metabolic process//intracellular signal transduction//obsolete electron transport//regulation of transcription, DNA-templated//ATP metabolic process GO:0046872//GO:0020037//GO:0003676//GO:0009055//GO:0003677//GO:0004519//GO:0004663//GO:0004017//GO:0003700//GO:0008270//GO:0043565 metal ion binding//heme binding//nucleic acid binding//electron carrier activity//DNA binding//endonuclease activity//Rab geranylgeranyltransferase activity//adenylate kinase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005968//GO:0005667//GO:0005634//GO:0019028 Rab-protein geranylgeranyltransferase complex//transcription factor complex//nucleus//viral capsid -- -- Cluster-8309.15355 BF_2 2.00 0.61 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15357 BF_2 7.00 0.64 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15358 BF_2 16.29 0.67 1301 478252462 ENN72884.1 506 1.8e-48 hypothetical protein YQE_10454, partial [Dendroctonus ponderosae]>gi|546682580|gb|ERL92499.1| hypothetical protein D910_09812 [Dendroctonus ponderosae] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 422 4.0e-40 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 PF12162 STAT1 TAZ2 binding domain -- -- GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.1536 BF_2 5.00 0.88 525 444730664 ELW71038.1 813 1.8e-84 40S ribosomal protein S19 [Tupaia chinensis] 33875112 BC000023.2 501 0 Homo sapiens ribosomal protein S19, mRNA (cDNA clone MGC:1630 IMAGE:3504083), complete cds K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 Q32PD5 748 2.6e-78 40S ribosomal protein S19 OS=Bos taurus GN=RPS19 PE=2 SV=3 PF01090//PF09339 Ribosomal protein S19e//IclR helix-turn-helix domain GO:0006355//GO:0006412//GO:0042254 regulation of transcription, DNA-templated//translation//ribosome biogenesis GO:0003677//GO:0003735 DNA binding//structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.15365 BF_2 71.23 1.60 2153 546676764 ERL87718.1 2118 3.5e-235 hypothetical protein D910_05108 [Dendroctonus ponderosae] 195122271 XM_002005600.1 48 2.01411e-13 Drosophila mojavensis GI18963 (Dmoj\GI18963), mRNA K08588 BAP1, UCHL2 ubiquitin carboxyl-terminal hydrolase BAP1 http://www.genome.jp/dbget-bin/www_bget?ko:K08588 Q17N72 1040 1.5e-111 Ubiquitin carboxyl-terminal hydrolase calypso OS=Aedes aegypti GN=calypso PE=3 SV=1 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006511//GO:0006508//GO:0016579 ubiquitin-dependent protein catabolic process//proteolysis//protein deubiquitination GO:0004843 ubiquitin-specific protease activity GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.15366 BF_2 169.68 1.75 4348 562874119 XP_006164934.1 411 6.2e-37 PREDICTED: zinc finger protein 717-like [Tupaia chinensis] 642932060 XM_008198621.1 176 2.87007e-84 PREDICTED: Tribolium castaneum protein lin-54 homolog (LOC663835), transcript variant X3, mRNA -- -- -- -- Q6P560 406 9.7e-38 Zinc finger protein 182 OS=Mus musculus GN=Znf182 PE=2 SV=1 PF13465//PF00096//PF07975//PF13912//PF00412//PF16622//PF01428 Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain//C2H2-type zinc finger//LIM domain//zinc-finger C2H2-type//AN1-like Zinc finger GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.15372 BF_2 128.00 2.02 2933 478257763 ENN77906.1 2103 2.7e-233 hypothetical protein YQE_05583, partial [Dendroctonus ponderosae] -- -- -- -- -- K15255 PIF1 ATP-dependent DNA helicase PIF1 http://www.genome.jp/dbget-bin/www_bget?ko:K15255 Q0R4F1 1295 5.4e-141 ATP-dependent DNA helicase PIF1 OS=Xenopus laevis GN=pif1 PE=2 SV=1 PF00005//PF03193//PF02689//PF02562//PF00270//PF05970//PF07728//PF01443//PF00004 ABC transporter//Protein of unknown function, DUF258//Helicase//PhoH-like protein//DEAD/DEAH box helicase//PIF1-like helicase//AAA domain (dynein-related subfamily)//Viral (Superfamily 1) RNA helicase//ATPase family associated with various cellular activities (AAA) GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0003678//GO:0005524//GO:0004386//GO:0003924//GO:0003676//GO:0016887//GO:0005525 DNA helicase activity//ATP binding//helicase activity//GTPase activity//nucleic acid binding//ATPase activity//GTP binding GO:0005657 replication fork KOG0987 DNA helicase PIF1/RRM3 Cluster-8309.15373 BF_2 22.60 1.91 782 642926566 XP_008194923.1 343 8.6e-30 PREDICTED: PP2C-like domain-containing protein CG9801 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0KIA2 222 3.8e-17 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228 Stage II sporulation protein E (SpoIIE) -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.15375 BF_2 68.79 0.66 4649 676426419 XP_009044617.1 831 1.3e-85 hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea]>gi|556116066|gb|ESP04718.1| hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 765 2.4e-79 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF16622//PF13912//PF01842//PF00130//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//ACT domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556//GO:0008152 intracellular signal transduction//metabolic process GO:0046872//GO:0016597 metal ion binding//amino acid binding -- -- -- -- Cluster-8309.15376 BF_2 114.09 3.25 1754 91084417 XP_967827.1 524 2.0e-50 PREDICTED: chromobox protein homolog 3 [Tribolium castaneum]>gi|270008703|gb|EFA05151.1| hypothetical protein TcasGA2_TC015268 [Tribolium castaneum] 242011614 XM_002426498.1 40 4.5773e-09 Pediculus humanus corporis hypothetical protein, mRNA K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83916 399 2.5e-37 Chromobox protein homolog 1 OS=Homo sapiens GN=CBX1 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.15377 BF_2 60.91 1.82 1685 91084417 XP_967827.1 524 1.9e-50 PREDICTED: chromobox protein homolog 3 [Tribolium castaneum]>gi|270008703|gb|EFA05151.1| hypothetical protein TcasGA2_TC015268 [Tribolium castaneum] 242011614 XM_002426498.1 40 4.39357e-09 Pediculus humanus corporis hypothetical protein, mRNA K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83917 399 2.4e-37 Chromobox protein homolog 1 OS=Mus musculus GN=Cbx1 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.15378 BF_2 56.00 4.33 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.15380 BF_2 3.00 1.44 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15382 BF_2 320.00 2.89 4927 642911878 XP_008199004.1 2614 2.5e-292 PREDICTED: zinc finger protein basonuclin-2-like [Tribolium castaneum] 642911877 XM_008200782.1 487 0 PREDICTED: Tribolium castaneum zinc finger protein basonuclin-2-like (LOC660322), mRNA -- -- -- -- Q6ZN30 524 2.3e-51 Zinc finger protein basonuclin-2 OS=Homo sapiens GN=BNC2 PE=1 SV=1 PF00096//PF02892 Zinc finger, C2H2 type//BED zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.15385 BF_2 19.99 3.24 545 478259603 ENN79456.1 143 9.2e-07 hypothetical protein YQE_04100, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887//PF01607//PF10152 Procyclic acidic repetitive protein (PARP)//Chitin binding Peritrophin-A domain//Predicted coiled-coil domain-containing protein (DUF2360) GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0071203//GO:0005576//GO:0016020 WASH complex//extracellular region//membrane -- -- Cluster-8309.15388 BF_2 31.00 5.92 506 294860856 ADF45324.1 471 7.9e-45 ubiquitin/ribosomal S30 fusion protein [Eriocheir sinensis] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 P0C2F0 174 9.0e-12 40S ribosomal protein S30 OS=Pongo abelii GN=FAU PE=3 SV=1 PF04758 Ribosomal protein S30 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-8309.15391 BF_2 8.00 0.87 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15400 BF_2 202.70 4.68 2099 642925170 XP_008194455.1 1610 2.8e-176 PREDICTED: endoglucanase 5-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YLG1 869 9.6e-92 Endoglucanase A OS=Bacillus pumilus GN=eglA PE=1 SV=1 PF00759//PF09204 Glycosyl hydrolase family 9//Bacterial self-protective colicin-like immunity GO:0005975//GO:0006955//GO:0030153 carbohydrate metabolic process//immune response//bacteriocin immunity GO:0015643//GO:0004553 toxic substance binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0019814 immunoglobulin complex -- -- Cluster-8309.15403 BF_2 25.28 0.38 3089 780626002 XP_011684334.1 531 5.4e-51 PREDICTED: uncharacterized protein LOC105447823 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15404 BF_2 35.18 0.45 3536 646697820 KDR09306.1 318 3.1e-26 Alpha-N-acetylglucosaminidase [Zootermopsis nevadensis] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 197 1.4e-13 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.15406 BF_2 48.00 1.61 1534 642921376 XP_008192841.1 431 1.0e-39 PREDICTED: uncharacterized protein LOC103312859 [Tribolium castaneum]>gi|270006270|gb|EFA02718.1| hypothetical protein TcasGA2_TC008442 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15408 BF_2 83.35 1.08 3510 478261830 ENN80953.1 638 2.4e-63 hypothetical protein YQE_02658, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15409 BF_2 22.69 0.56 1974 478255734 ENN75943.1 514 3.2e-49 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 Q5ZKA5 430 7.3e-41 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Gallus gallus GN=MTHFD2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.15410 BF_2 194.90 7.45 1382 478255734 ENN75943.1 1150 4.0e-123 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 Q0P5C2 877 7.5e-93 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Bos taurus GN=MTHFD2 PE=2 SV=1 PF00763//PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0055114//GO:0046487//GO:0009396 oxidation-reduction process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.15411 BF_2 41.00 1.63 1340 642933815 XP_008197379.1 775 1.2e-79 PREDICTED: protein FAM86D [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1JPJ9 336 3.9e-30 Protein-lysine N-methyltransferase EEF2KMT OS=Bos taurus GN=EEF2KMT PE=2 SV=2 PF05175 Methyltransferase small domain -- -- GO:0008168 methyltransferase activity -- -- KOG2497 Predicted methyltransferase Cluster-8309.15413 BF_2 54.62 6.11 661 662197889 XP_008472044.1 628 6.5e-63 PREDICTED: adrenodoxin-like protein, mitochondrial [Diaphorina citri]>gi|662197891|ref|XP_008472045.1| PREDICTED: adrenodoxin-like protein, mitochondrial [Diaphorina citri]>gi|662197893|ref|XP_008472047.1| PREDICTED: adrenodoxin-like protein, mitochondrial [Diaphorina citri] 645007869 XM_001600661.3 119 2.02712e-53 PREDICTED: Nasonia vitripennis adrenodoxin-like protein, mitochondrial (LOC100118135), mRNA -- -- -- -- P37193 568 2.4e-57 Adrenodoxin-like protein, mitochondrial OS=Drosophila melanogaster GN=Fdxh PE=2 SV=3 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0009055//GO:0051536 electron carrier activity//iron-sulfur cluster binding -- -- KOG3309 Ferredoxin Cluster-8309.15416 BF_2 40.00 3.57 756 91080437 XP_968816.1 678 1.2e-68 PREDICTED: metallo-beta-lactamase domain-containing protein 1 [Tribolium castaneum]>gi|270005573|gb|EFA02021.1| hypothetical protein TcasGA2_TC007644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498J9 335 2.9e-30 Metallo-beta-lactamase domain-containing protein 1 OS=Xenopus laevis GN=mblac1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4736 Uncharacterized conserved protein Cluster-8309.15420 BF_2 89.36 1.93 2228 642934956 XP_008195951.1 2060 1.9e-228 PREDICTED: TNF receptor-associated factor 4 isoform X3 [Tribolium castaneum] 817199300 XM_012419904.1 272 6.28467e-138 PREDICTED: Orussus abietinus TNF receptor-associated factor 4 (LOC105696990), transcript variant X2, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 1177 2.0e-127 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF03145//PF15965//PF00096//PF02176 Seven in absentia protein family//TRAF-like zinc-finger//Zinc finger, C2H2 type//TRAF-type zinc finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG0297 TNF receptor-associated factor Cluster-8309.15421 BF_2 8.00 1.02 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15423 BF_2 8.97 0.41 1207 546674258 ERL85677.1 744 4.2e-76 hypothetical protein D910_03093 [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q55E31 467 2.3e-45 Ras-related protein Rab-32B OS=Dictyostelium discoideum GN=rab32B PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15428 BF_2 206.05 4.69 2124 189234613 XP_001816367.1 502 8.5e-48 PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913888|ref|XP_008201202.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913890|ref|XP_008201203.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|270001651|gb|EEZ98098.1| hypothetical protein TcasGA2_TC000511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15429 BF_2 274.12 6.85 1961 189234613 XP_001816367.1 502 7.8e-48 PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913888|ref|XP_008201202.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|642913890|ref|XP_008201203.1| PREDICTED: uncharacterized protein LOC100142270 [Tribolium castaneum]>gi|270001651|gb|EEZ98098.1| hypothetical protein TcasGA2_TC000511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15431 BF_2 18.00 0.42 2097 91092974 XP_967289.1 188 2.2e-11 PREDICTED: TPPP family protein CG45057 [Tribolium castaneum]>gi|270003162|gb|EEZ99609.1| hypothetical protein TcasGA2_TC002126 [Tribolium castaneum] 827558552 XM_012694950.1 37 2.55454e-07 PREDICTED: Bombyx mori TPPP family protein CG45057-like (LOC101741645), transcript variant X2, mRNA -- -- -- -- Q9VV43 151 1.7e-08 TPPP family protein CG45057 OS=Drosophila melanogaster GN=CG45057 PE=2 SV=1 PF08688 Apx/Shroom domain ASD1 -- -- GO:0051015 actin filament binding -- -- -- -- Cluster-8309.15432 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15441 BF_2 28.00 6.40 470 94468538 ABF18118.1 193 1.3e-12 TIL domain-containing cysteine-rich salivary secreted peptide [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q8T0W0 122 8.9e-06 Cysteine-rich venom protein 6 OS=Pimpla hypochondriaca PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15444 BF_2 1.00 0.98 320 385145418 CCG28034.1 553 1.6e-54 beta tubulin 1 [Sepia officinalis] 655881817 XM_002720955.2 199 3.13238e-98 PREDICTED: Oryctolagus cuniculus tubulin, beta 2B class IIb (TUBB2B), mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q6P9T8 551 1.1e-55 Tubulin beta-4B chain OS=Rattus norvegicus GN=Tubb4b PE=1 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.15452 BF_2 37.34 22.86 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15456 BF_2 277.14 10.29 1414 91090910 XP_973922.1 1130 8.6e-121 PREDICTED: protein rogdi isoform X1 [Tribolium castaneum]>gi|270013221|gb|EFA09669.1| hypothetical protein TcasGA2_TC011795 [Tribolium castaneum] 805780431 XM_012283623.1 73 1.66073e-27 PREDICTED: Megachile rotundata protein rogdi (LOC100879337), transcript variant X2, mRNA -- -- -- -- Q9VVE2 833 9.7e-88 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3992 Uncharacterized conserved protein Cluster-8309.15461 BF_2 39.74 1.11 1782 642923022 XP_008200499.1 709 7.1e-72 PREDICTED: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62377 381 3.2e-35 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 OS=Mus musculus GN=Zrsr2 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.15463 BF_2 3.10 0.36 649 642910771 XP_008193403.1 346 3.2e-30 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10297 Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.15465 BF_2 86.01 2.30 1851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15467 BF_2 225.15 5.76 1923 642931074 XP_974160.2 683 7.9e-69 PREDICTED: stimulator of interferon genes protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TBT3 199 4.3e-14 Stimulator of interferon genes protein OS=Mus musculus GN=Tmem173 PE=1 SV=2 PF15009 Transmembrane protein 173 GO:0002218//GO:0032481 activation of innate immune response//positive regulation of type I interferon production -- -- -- -- -- -- Cluster-8309.15468 BF_2 5.00 0.34 904 270005125 EFA01573.1 414 5.8e-38 hypothetical protein TcasGA2_TC007134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00046//PF09726 Homeobox domain//Transmembrane protein -- -- GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.15469 BF_2 6.96 0.63 748 478257743 ENN77886.1 155 5.1e-08 hypothetical protein YQE_05564, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15470 BF_2 15.82 0.99 954 645040646 XP_008210807.1 152 1.5e-07 PREDICTED: uncharacterized protein LOC100117040 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.15471 BF_2 16.00 0.60 1402 91076418 XP_970494.1 789 2.9e-81 PREDICTED: uncharacterized protein LOC659067 [Tribolium castaneum]>gi|270002440|gb|EEZ98887.1| hypothetical protein TcasGA2_TC004502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0003676//GO:0016787 metal ion binding//nucleic acid binding//hydrolase activity -- -- -- -- Cluster-8309.15475 BF_2 132.49 5.69 1261 91094761 XP_966940.1 634 2.5e-63 PREDICTED: trafficking protein particle complex subunit 1 [Tribolium castaneum]>gi|270016552|gb|EFA12998.1| hypothetical protein TcasGA2_TC001478 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5NCF2 480 7.4e-47 Trafficking protein particle complex subunit 1 OS=Mus musculus GN=Trappc1 PE=1 SV=1 PF04628//PF04099 Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005622//GO:0005801 intracellular//cis-Golgi network KOG3368 Transport protein particle (TRAPP) complex subunit Cluster-8309.15483 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15484 BF_2 7.00 0.61 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15486 BF_2 23.65 1.91 805 91093076 XP_968784.1 693 2.3e-70 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 584 4.1e-59 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.15488 BF_2 137.00 7.95 1008 642923784 XP_974439.3 385 1.5e-34 PREDICTED: probable 28S ribosomal protein S26, mitochondrial [Tribolium castaneum]>gi|270006944|gb|EFA03392.1| hypothetical protein TcasGA2_TC013378 [Tribolium castaneum] -- -- -- -- -- K17405 MRPS26 small subunit ribosomal protein S26 http://www.genome.jp/dbget-bin/www_bget?ko:K17405 Q9VVN2 316 6.1e-28 Probable 28S ribosomal protein S26, mitochondrial OS=Drosophila melanogaster GN=mRpS26 PE=2 SV=1 PF14943//PF12328//PF02482 Mitochondrial ribosome subunit S26//Rpp20 subunit of nuclear RNase MRP and P//Sigma 54 modulation protein / S30EA ribosomal protein GO:0051252//GO:0008033//GO:0044238 regulation of RNA metabolic process//tRNA processing//primary metabolic process GO:0004526 ribonuclease P activity GO:0030677//GO:0005763//GO:0005634 ribonuclease P complex//mitochondrial small ribosomal subunit//nucleus -- -- Cluster-8309.15489 BF_2 9.00 1.42 553 861484529 XP_012920569.1 164 3.5e-09 PREDICTED: THAP domain-containing protein 3 isoform X5 [Heterocephalus glaber] -- -- -- -- -- -- -- -- -- Q8WTV1 159 5.4e-10 THAP domain-containing protein 3 OS=Homo sapiens GN=THAP3 PE=1 SV=1 PF04471//PF05485 Restriction endonuclease//THAP domain GO:0009307 DNA restriction-modification system GO:0003676//GO:0003677//GO:0004519 nucleic acid binding//DNA binding//endonuclease activity -- -- -- -- Cluster-8309.15490 BF_2 239.04 2.95 3680 646702401 KDR11613.1 2159 1.1e-239 Mothers against decapentaplegic-like protein 4 [Zootermopsis nevadensis] 552954715 KF307635.1 131 2.51278e-59 Pinctada fucata TGF beta signaling pathway factor (smad4) mRNA, complete cds K04501 SMAD4 mothers against decapentaplegic homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04501 Q9GKQ9 1075 2.2e-115 Mothers against decapentaplegic homolog 4 OS=Sus scrofa GN=SMAD4 PE=2 SV=1 PF03165//PF03166 MH1 domain//MH2 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.15496 BF_2 1.00 1.82 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15499 BF_2 191.87 4.36 2126 642936794 XP_008199618.1 257 2.2e-19 PREDICTED: protein kish-A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWH8 236 2.4e-18 Protein kish OS=Drosophila melanogaster GN=ksh PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15500 BF_2 4.00 1.43 403 426374315 XP_004054021.1 677 8.2e-69 PREDICTED: 40S ribosomal protein S2-like isoform 1 [Gorilla gorilla gorilla]>gi|426374317|ref|XP_004054022.1| PREDICTED: 40S ribosomal protein S2-like isoform 2 [Gorilla gorilla gorilla]>gi|426374319|ref|XP_004054023.1| PREDICTED: 40S ribosomal protein S2-like isoform 3 [Gorilla gorilla gorilla]>gi|426374321|ref|XP_004054024.1| PREDICTED: 40S ribosomal protein S2-like isoform 4 [Gorilla gorilla gorilla] 42542642 BC066321.1 403 0 Homo sapiens ribosomal protein S2, mRNA (cDNA clone MGC:87212 IMAGE:5296344), complete cds K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 O18789 638 1.1e-65 40S ribosomal protein S2 OS=Bos taurus GN=RPS2 PE=2 SV=2 PF03719 Ribosomal protein S5, C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.15501 BF_2 3.24 0.38 639 728418383 AIY68367.1 345 4.1e-30 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15502 BF_2 74.98 0.81 4136 478259446 ENN79336.1 1032 5.8e-109 hypothetical protein YQE_04245, partial [Dendroctonus ponderosae]>gi|546675187|gb|ERL86423.1| hypothetical protein D910_03830 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O42602 211 3.8e-15 Corticotropin-releasing factor receptor 1 OS=Xenopus laevis GN=crhr1 PE=2 SV=1 PF00002//PF02793//PF08655 7 transmembrane receptor (Secretin family)//Hormone receptor domain//DASH complex subunit Ask1 GO:0008608//GO:0007186 attachment of spindle microtubules to kinetochore//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0072686//GO:0042729//GO:0016021 membrane//mitotic spindle//DASH complex//integral component of membrane -- -- Cluster-8309.15503 BF_2 231.20 3.80 2829 478259446 ENN79336.1 1383 7.9e-150 hypothetical protein YQE_04245, partial [Dendroctonus ponderosae]>gi|546675187|gb|ERL86423.1| hypothetical protein D910_03830 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q16602 345 7.5e-31 Calcitonin gene-related peptide type 1 receptor OS=Homo sapiens GN=CALCRL PE=1 SV=2 PF08655//PF02793//PF00002 DASH complex subunit Ask1//Hormone receptor domain//7 transmembrane receptor (Secretin family) GO:0007186//GO:0008608 G-protein coupled receptor signaling pathway//attachment of spindle microtubules to kinetochore GO:0004930 G-protein coupled receptor activity GO:0072686//GO:0016020//GO:0016021//GO:0042729 mitotic spindle//membrane//integral component of membrane//DASH complex -- -- Cluster-8309.15504 BF_2 73.35 1.18 2889 478259446 ENN79336.1 1352 3.2e-146 hypothetical protein YQE_04245, partial [Dendroctonus ponderosae]>gi|546675187|gb|ERL86423.1| hypothetical protein D910_03830 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q16602 330 4.2e-29 Calcitonin gene-related peptide type 1 receptor OS=Homo sapiens GN=CALCRL PE=1 SV=2 PF00002//PF08655//PF02793 7 transmembrane receptor (Secretin family)//DASH complex subunit Ask1//Hormone receptor domain GO:0007186//GO:0008608 G-protein coupled receptor signaling pathway//attachment of spindle microtubules to kinetochore GO:0004930 G-protein coupled receptor activity GO:0042729//GO:0016021//GO:0016020//GO:0072686 DASH complex//integral component of membrane//membrane//mitotic spindle -- -- Cluster-8309.15505 BF_2 3.00 0.77 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01383 CpcD/allophycocyanin linker domain -- -- -- -- GO:0030089 phycobilisome -- -- Cluster-8309.15508 BF_2 31.22 1.10 1479 189241797 XP_001812480.1 207 9.5e-14 PREDICTED: cytochrome c oxidase subunit 6C [Tribolium castaneum]>gi|270001250|gb|EEZ97697.1| hypothetical protein TcasGA2_TC011006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.15509 BF_2 2.00 2.98 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15510 BF_2 11.00 0.89 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15514 BF_2 11.87 0.48 1329 270009040 EFA05488.1 248 1.5e-18 hypothetical protein TcasGA2_TC015673 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 200 2.3e-14 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.15521 BF_2 16.00 0.40 1974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15522 BF_2 7.00 0.53 842 270016418 EFA12864.1 256 1.1e-19 hypothetical protein TcasGA2_TC004246 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15523 BF_2 27.00 0.55 2342 642939272 XP_008192906.1 209 8.9e-14 PREDICTED: polycomb group protein Psc-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15529 BF_2 57.20 0.48 5308 642922353 XP_008193121.1 1137 5.0e-121 PREDICTED: male-specific lethal 1 homolog [Tribolium castaneum] -- -- -- -- -- K13163 MSL1 male-specific lethal 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13163 A9JRX0 283 2.2e-23 Male-specific lethal 1-like 1 OS=Danio rerio GN=msl1l1 PE=2 SV=1 PF15460 Something about silencing, SAS, complex subunit 4 GO:0016573 histone acetylation -- -- -- -- -- -- Cluster-8309.15531 BF_2 15.46 0.33 2277 642917401 XP_008191181.1 1711 5.9e-188 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Tribolium castaneum] 167777849 CP000786.1 38 7.72259e-08 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome I, complete sequence -- -- -- -- A1L258 1469 2.8e-161 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF02913//PF01565 FAD linked oxidases, C-terminal domain//FAD binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0003824//GO:0050660 oxidoreductase activity//catalytic activity//flavin adenine dinucleotide binding -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.15532 BF_2 2.00 0.57 433 -- -- -- -- -- 642917441 XM_008192979.1 36 1.78342e-07 PREDICTED: Tribolium castaneum jerky protein homolog-like (LOC103312418), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15535 BF_2 35.93 0.86 2043 642927610 XP_008195334.1 1631 9.9e-179 PREDICTED: conserved oligomeric Golgi complex subunit 1 [Tribolium castaneum]>gi|270011053|gb|EFA07501.1| pebbled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z160 394 1.1e-36 Conserved oligomeric Golgi complex subunit 1 OS=Mus musculus GN=Cog1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2033 Low density lipoprotein B-like protein Cluster-8309.15536 BF_2 130.07 3.20 1987 642927610 XP_008195334.1 1859 3.5e-205 PREDICTED: conserved oligomeric Golgi complex subunit 1 [Tribolium castaneum]>gi|270011053|gb|EFA07501.1| pebbled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z160 413 6.8e-39 Conserved oligomeric Golgi complex subunit 1 OS=Mus musculus GN=Cog1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2033 Low density lipoprotein B-like protein Cluster-8309.15538 BF_2 1.00 2.59 275 91079768 XP_966889.1 135 3.9e-06 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.15540 BF_2 2.00 0.33 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02918 Pertussis toxin, subunit 2 and 3, C-terminal domain GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.15541 BF_2 15.00 1.96 607 -- -- -- -- -- 462470890 APGK01002612.1 41 4.24353e-10 Dendroctonus ponderosae Seq01002612, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15545 BF_2 4.00 0.66 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15550 BF_2 19.00 1.09 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15555 BF_2 13.00 0.70 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15556 BF_2 13.00 0.32 2006 646696203 KDR08650.1 529 5.9e-51 Programmed cell death protein 4 [Zootermopsis nevadensis] -- -- -- -- -- K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 414 5.3e-39 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.15560 BF_2 19.00 3.31 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15561 BF_2 228.00 12.81 1032 478260709 ENN80392.1 211 2.3e-14 hypothetical protein YQE_03184, partial [Dendroctonus ponderosae]>gi|546683578|gb|ERL93376.1| hypothetical protein D910_10668 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4IAB8 142 9.4e-08 Vacuolar ATPase assembly integral membrane protein VMA21 homolog OS=Drosophila sechellia GN=GM22297 PE=3 SV=1 PF09446 VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- -- -- -- -- Cluster-8309.15562 BF_2 12.00 3.04 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15571 BF_2 74.22 1.09 3144 546674862 ERL86148.1 1070 1.7e-113 hypothetical protein D910_03561 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZQN7 268 7.0e-22 Solute carrier organic anion transporter family member 4C1 OS=Homo sapiens GN=SLCO4C1 PE=1 SV=1 PF03137//PF07690 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3626 Organic anion transporter Cluster-8309.15572 BF_2 79.20 2.58 1572 270014160 EFA10608.1 1189 1.4e-127 hypothetical protein TcasGA2_TC012869 [Tribolium castaneum] 642936636 XM_008200296.1 81 6.61048e-32 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q24206 398 3.0e-37 Broad-complex core protein isoform 6 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF13912//PF02892//PF16622//PF00651//PF13465//PF00096 C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//BTB/POZ domain//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.15574 BF_2 18.00 1.77 712 6006555 CAB56793.1 418 1.6e-38 proto-oncogene [Homo sapiens] 212720875 NG_008996.1 703 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2IBF2 418 6.4e-40 Hepatocyte growth factor receptor OS=Gorilla gorilla gorilla GN=MET PE=3 SV=1 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.15575 BF_2 171.69 1.39 5453 642924251 XP_008194216.1 4280 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19464 PLEKHG5 pleckstrin homology domain-containing family G member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K19464 Q6RFZ7 762 6.4e-79 Pleckstrin homology domain-containing family G member 5 OS=Rattus norvegicus GN=Plekhg5 PE=1 SV=1 PF11808//PF03611//PF00621//PF02196//PF04898 Domain of unknown function (DUF3329)//PTS system sugar-specific permease component//RhoGEF domain//Raf-like Ras-binding domain//Glutamate synthase central domain GO:0016310//GO:0035023//GO:0006537//GO:0007165//GO:0006807//GO:0055114//GO:0043087//GO:0009401 phosphorylation//regulation of Rho protein signal transduction//glutamate biosynthetic process//signal transduction//nitrogen compound metabolic process//oxidation-reduction process//regulation of GTPase activity//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005057//GO:0005089//GO:0015930//GO:0004673 receptor signaling protein activity//Rho guanyl-nucleotide exchange factor activity//glutamate synthase activity//protein histidine kinase activity GO:0009365//GO:0016021 protein histidine kinase complex//integral component of membrane KOG3521 Predicted guanine nucleotide exchange factor Cluster-8309.15580 BF_2 224.00 8.73 1360 642921238 XP_008192777.1 884 2.8e-92 PREDICTED: rRNA-processing protein FCF1 homolog [Tribolium castaneum] 572304285 XM_006618048.1 202 3.10632e-99 PREDICTED: Apis dorsata rRNA-processing protein FCF1 homolog (LOC102672622), transcript variant X2, mRNA K14566 UTP24, FCF1 U3 small nucleolar RNA-associated protein 24 http://www.genome.jp/dbget-bin/www_bget?ko:K14566 Q32PD0 741 4.3e-77 rRNA-processing protein FCF1 homolog OS=Bos taurus GN=FCF1 PE=2 SV=1 PF04900 Fcf1 -- -- -- -- GO:0032040 small-subunit processome KOG3165 Predicted nucleic-acid-binding protein, contains PIN domain Cluster-8309.15584 BF_2 28.00 0.66 2055 91081495 XP_974508.1 1420 2.9e-154 PREDICTED: DNA-binding protein D-ETS-6 [Tribolium castaneum]>gi|270005143|gb|EFA01591.1| hypothetical protein TcasGA2_TC007154 [Tribolium castaneum] 488552843 XM_004467731.1 135 8.32676e-62 PREDICTED: Dasypus novemcinctus FEV (ETS oncogene family) (FEV), mRNA K09436 FLI1 friend leukemia integration 1 transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09436 P29776 762 2.4e-79 DNA-binding protein D-ETS-6 OS=Drosophila melanogaster GN=Ets21C PE=2 SV=2 PF00447//PF02198//PF00178//PF07571 HSF-type DNA-binding//Sterile alpha motif (SAM)/Pointed domain//Ets-domain//TAF6 C-terminal HEAT repeat domain GO:0051090//GO:0006355 regulation of sequence-specific DNA binding transcription factor activity//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3806 Predicted transcription factor Cluster-8309.15586 BF_2 9.00 1.96 479 194246089 ACF35536.1 438 5.0e-41 ribosomal protein L34 [Dermacentor variabilis] -- -- -- -- -- K02915 RP-L34e, RPL34 large subunit ribosomal protein L34e http://www.genome.jp/dbget-bin/www_bget?ko:K02915 Q9D1R9 355 8.7e-33 60S ribosomal protein L34 OS=Mus musculus GN=Rpl34 PE=1 SV=2 PF01199 Ribosomal protein L34e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1790 60s ribosomal protein L34 Cluster-8309.15589 BF_2 4.00 6.51 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15591 BF_2 225.00 3.69 2835 91093959 XP_968177.1 2398 1.6e-267 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270010930|gb|EFA07378.1| hypothetical protein TcasGA2_TC016355 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1539 2.6e-169 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF04234//PF01266//PF05834//PF00732//PF07992 GMC oxidoreductase//CopC domain//FAD dependent oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0046688//GO:0055114//GO:0016117 response to copper ion//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0005507//GO:0016705//GO:0016614//GO:0050660 oxidoreductase activity//copper ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding GO:0042597 periplasmic space -- -- Cluster-8309.15599 BF_2 164.00 2.43 3115 675376395 KFM69297.1 146 2.4e-06 hypothetical protein X975_03065, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020 Ribosomal L40e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.15606 BF_2 240.63 7.58 1615 642921579 XP_008192431.1 1070 8.9e-114 PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum]>gi|642921581|ref|XP_008192432.1| PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum] 642921580 XM_008194210.1 260 2.1216e-131 PREDICTED: Tribolium castaneum MOB kinase activator-like 2 (LOC657020), transcript variant X2, mRNA -- -- -- -- Q2LZ59 929 8.2e-99 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.15609 BF_2 148.78 33.09 475 91087977 XP_973274.1 400 1.3e-36 PREDICTED: U6 snRNA-associated Sm-like protein LSm3 [Tribolium castaneum]>gi|270011905|gb|EFA08353.1| hypothetical protein TcasGA2_TC005996 [Tribolium castaneum] -- -- -- -- -- K12622 LSM3 U6 snRNA-associated Sm-like protein LSm3 http://www.genome.jp/dbget-bin/www_bget?ko:K12622 P62310 312 8.4e-28 U6 snRNA-associated Sm-like protein LSm3 OS=Homo sapiens GN=LSM3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3460 Small nuclear ribonucleoprotein (snRNP) LSM3 Cluster-8309.15614 BF_2 5.00 15.68 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15617 BF_2 30.28 0.32 4257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1562 BF_2 48.00 0.49 4390 546683810 ERL93563.1 4261 0.0e+00 hypothetical protein D910_10852 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2569 1.5e-288 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF03969//PF02367//PF06414//PF01637//PF03193//PF00005//PF00004//PF00437//PF13304//PF01926//PF00664//PF08477 NB-ARC domain//AFG1-like ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase GO:0055085//GO:0006810//GO:0002949//GO:0007264 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626 ATP binding//ADP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.15624 BF_2 14.00 1.28 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15625 BF_2 2.00 0.64 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15626 BF_2 28.00 0.38 3335 242020354 XP_002430620.1 618 4.7e-61 leucine-rich repeat-containing protein, putative [Pediculus humanus corporis]>gi|212515792|gb|EEB17882.1| leucine-rich repeat-containing protein, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q5ZLN0 183 5.4e-12 Leucine-rich repeat-containing protein 40 OS=Gallus gallus GN=LRRC40 PE=2 SV=1 PF04815//PF00560//PF13855 Sec23/Sec24 helical domain//Leucine Rich Repeat//Leucine rich repeat GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0005515 protein binding GO:0030127 COPII vesicle coat KOG0619 FOG: Leucine rich repeat Cluster-8309.15627 BF_2 8.79 0.34 1364 642925638 XP_008194650.1 1100 2.5e-117 PREDICTED: putative fatty acyl-CoA reductase CG5065 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 664 3.7e-68 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01118//PF01370//PF03015//PF05805 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Male sterility protein//L6 membrane protein GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process GO:0080019//GO:0016620//GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding GO:0016021 integral component of membrane -- -- Cluster-8309.15628 BF_2 4.00 0.59 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15629 BF_2 4.00 0.86 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15632 BF_2 3.03 0.66 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15635 BF_2 16.00 0.92 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15636 BF_2 63.52 1.19 2511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083//PF00895 Partial alpha/beta-hydrolase lipase region//ATP synthase protein 8 GO:0015986//GO:0015992//GO:0006629 ATP synthesis coupled proton transport//proton transport//lipid metabolic process GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.15637 BF_2 82.66 1.00 3750 478250611 ENN71103.1 1166 1.5e-124 hypothetical protein YQE_12036, partial [Dendroctonus ponderosae]>gi|546673105|gb|ERL84774.1| hypothetical protein D910_02199 [Dendroctonus ponderosae] -- -- -- -- -- K12195 CHMP6, VPS20 charged multivesicular body protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12195 O18391 805 4.5e-84 Probable serine hydrolase OS=Drosophila melanogaster GN=kraken PE=2 SV=1 PF01063//PF03357//PF07819//PF01764//PF01674//PF00975 Amino-transferase class IV//Snf7//PGAP1-like protein//Lipase (class 3)//Lipase (class 2)//Thioesterase domain GO:0007034//GO:0009058//GO:0006505//GO:0008152//GO:0006629//GO:0006886 vacuolar transport//biosynthetic process//GPI anchor metabolic process//metabolic process//lipid metabolic process//intracellular protein transport GO:0003824//GO:0016788//GO:0016787 catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- -- -- Cluster-8309.15638 BF_2 35.62 3.00 784 642933343 XP_008197375.1 451 2.6e-42 PREDICTED: charged multivesicular body protein 6-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K12195 CHMP6, VPS20 charged multivesicular body protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12195 Q6GMA4 329 1.5e-29 Charged multivesicular body protein 6-A OS=Xenopus laevis GN=chmp6-a PE=2 SV=3 PF01063//PF03357//PF06112 Amino-transferase class IV//Snf7//Gammaherpesvirus capsid protein GO:0008152//GO:0007034 metabolic process//vacuolar transport GO:0003824 catalytic activity GO:0019028 viral capsid KOG2910 Uncharacterized conserved protein predicted to be involved in protein sorting Cluster-8309.15645 BF_2 288.95 2.92 4433 642917187 XP_966629.2 4401 0.0e+00 PREDICTED: transient receptor potential channel pyrexia [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 1005 3.4e-107 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF13606//PF00023//PF00520//PF06005 Ankyrin repeat//Ankyrin repeat//Ion transport protein//Protein of unknown function (DUF904) GO:0000917//GO:0006811//GO:0043093//GO:0055085 barrier septum assembly//ion transport//FtsZ-dependent cytokinesis//transmembrane transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-8309.15647 BF_2 5.00 0.35 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15648 BF_2 47.97 1.46 1659 642936319 XP_008198394.1 638 1.1e-63 PREDICTED: equilibrative nucleoside transporter 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZD2 241 5.0e-19 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733//PF05392//PF07690 Nucleoside transporter//Cytochrome C oxidase chain VIIB//Major Facilitator Superfamily GO:0015992//GO:0006810//GO:0006123//GO:0015858//GO:0055085 proton transport//transport//mitochondrial electron transport, cytochrome c to oxygen//nucleoside transport//transmembrane transport GO:0005337//GO:0004129 nucleoside transmembrane transporter activity//cytochrome-c oxidase activity GO:0045277//GO:0005746//GO:0016021 respiratory chain complex IV//mitochondrial respiratory chain//integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.15649 BF_2 55.37 0.68 3714 91083357 XP_975102.1 2572 1.4e-287 PREDICTED: suppressor of hairless protein [Tribolium castaneum]>gi|270008236|gb|EFA04684.1| suppressor of hairless [Tribolium castaneum] 642923838 XM_970009.2 515 0 PREDICTED: Tribolium castaneum suppressor of hairless (LOC663984), mRNA K06053 RBPSUH, RBPJK recombining binding protein suppressor of hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06053 P28159 2150 4.9e-240 Suppressor of hairless protein OS=Drosophila melanogaster GN=Su(H) PE=1 SV=1 PF01833//PF09271//PF09270 IPT/TIG domain//LAG1, DNA binding//Beta-trefoil DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0000978//GO:0003700//GO:0000982//GO:0005515//GO:0003677 RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//protein binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3743 Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) Cluster-8309.15650 BF_2 98.16 1.33 3386 91083357 XP_975102.1 2572 1.3e-287 PREDICTED: suppressor of hairless protein [Tribolium castaneum]>gi|270008236|gb|EFA04684.1| suppressor of hairless [Tribolium castaneum] 642923838 XM_970009.2 518 0 PREDICTED: Tribolium castaneum suppressor of hairless (LOC663984), mRNA K06053 RBPSUH, RBPJK recombining binding protein suppressor of hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06053 P28159 2150 4.5e-240 Suppressor of hairless protein OS=Drosophila melanogaster GN=Su(H) PE=1 SV=1 PF01833//PF09270//PF09271 IPT/TIG domain//Beta-trefoil DNA-binding domain//LAG1, DNA binding GO:0006355 regulation of transcription, DNA-templated GO:0000982//GO:0000978//GO:0003700//GO:0003677//GO:0005515 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3743 Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) Cluster-8309.15651 BF_2 232.58 1.29 7826 642923170 XP_008193638.1 1098 2.4e-116 PREDICTED: uncharacterized protein LOC103313086 [Tribolium castaneum] 642923169 XM_008195416.1 353 0 PREDICTED: Tribolium castaneum uncharacterized LOC103313086 (LOC103313086), mRNA -- -- -- -- A2AWH2 159 7.6e-09 Transmembrane protein FAM155A OS=Danio rerio GN=fam155a PE=2 SV=1 PF01392 Fz domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15654 BF_2 49.00 3.85 820 546685347 ERL94874.1 243 3.5e-18 hypothetical protein D910_12147 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15655 BF_2 171.33 5.92 1498 478257377 ENN77535.1 412 1.6e-37 hypothetical protein YQE_05983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0055114//GO:0006570//GO:0006118 oxidation-reduction process//tyrosine metabolic process//obsolete electron transport GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.15656 BF_2 8.00 0.61 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15657 BF_2 280.13 2.93 4283 91078420 XP_974692.1 1424 2.1e-154 PREDICTED: tektin-3 [Tribolium castaneum]>gi|270003874|gb|EFA00322.1| hypothetical protein TcasGA2_TC003160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16T79 1220 3.9e-132 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Aedes aegypti GN=AAEL010360 PE=3 SV=2 PF16716//PF03082//PF02951//PF07728//PF03255//PF00931//PF06414//PF09177//PF10018//PF01544//PF01920//PF00437//PF16331//PF01583//PF08702//PF08912//PF03938//PF08653//PF07989//PF03193//PF00005 Bone marrow stromal antigen 2//Male accessory gland secretory protein//Prokaryotic glutathione synthetase, N-terminal domain//AAA domain (dynein-related subfamily)//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//NB-ARC domain//Zeta toxin//Syntaxin 6, N-terminal//Vitamin-D-receptor interacting Mediator subunit 4//CorA-like Mg2+ transporter protein//Prefoldin subunit//Type II/IV secretion system protein//TolA binding protein trimerisation//Adenylylsulphate kinase//Fibrinogen alpha/beta chain family//Rho Binding//Outer membrane protein (OmpH-like)//DASH complex subunit Dam1//Centrosomin N-terminal motif 1//Protein of unknown function, DUF258//ABC transporter GO:0030168//GO:0048193//GO:0000103//GO:0006633//GO:0006750//GO:0006357//GO:0008608//GO:0006090//GO:0055085//GO:0000226//GO:0007618//GO:0051607//GO:0006144//GO:0030001//GO:0006457//GO:0051258//GO:0006810//GO:0070206//GO:0007165 platelet activation//Golgi vesicle transport//sulfate assimilation//fatty acid biosynthetic process//glutathione biosynthetic process//regulation of transcription from RNA polymerase II promoter//attachment of spindle microtubules to kinetochore//pyruvate metabolic process//transmembrane transport//microtubule cytoskeleton organization//mating//defense response to virus//purine nucleobase metabolic process//metal ion transport//protein folding//protein polymerization//transport//protein trimerization//signal transduction GO:0003989//GO:0017048//GO:0030674//GO:0046873//GO:0001104//GO:0051082//GO:0016301//GO:0005102//GO:0016887//GO:0003924//GO:0005524//GO:0005525//GO:0043531//GO:0004020//GO:0004363 acetyl-CoA carboxylase activity//Rho GTPase binding//protein binding, bridging//metal ion transmembrane transporter activity//RNA polymerase II transcription cofactor activity//unfolded protein binding//kinase activity//receptor binding//ATPase activity//GTPase activity//ATP binding//GTP binding//ADP binding//adenylylsulfate kinase activity//glutathione synthase activity GO:0016592//GO:0072686//GO:0016272//GO:0005577//GO:0005576//GO:0016020//GO:0005874//GO:0009317//GO:0042729//GO:0005815 mediator complex//mitotic spindle//prefoldin complex//fibrinogen complex//extracellular region//membrane//microtubule//acetyl-CoA carboxylase complex//DASH complex//microtubule organizing center KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.15663 BF_2 64.61 0.93 3196 815765768 XP_012215589.1 186 5.6e-11 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q9D305 146 1.0e-07 THAP domain-containing protein 2 OS=Mus musculus GN=Thap2 PE=2 SV=1 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.15667 BF_2 11.89 0.42 1476 91088781 XP_976139.1 385 2.2e-34 PREDICTED: methylosome protein 50 [Tribolium castaneum]>gi|270011629|gb|EFA08077.1| hypothetical protein TcasGA2_TC005673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15668 BF_2 128.88 4.90 1387 91088781 XP_976139.1 805 4.1e-83 PREDICTED: methylosome protein 50 [Tribolium castaneum]>gi|270011629|gb|EFA08077.1| hypothetical protein TcasGA2_TC005673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54H44 136 6.3e-07 WD repeat domain-containing protein 83 homolog OS=Dictyostelium discoideum GN=morg1 PE=3 SV=1 PF06017//PF00400 Unconventional myosin tail, actin- and lipid-binding//WD domain, G-beta repeat -- -- GO:0003774//GO:0005515 motor activity//protein binding GO:0016459 myosin complex -- -- Cluster-8309.15676 BF_2 12.44 0.62 1130 641672407 XP_008185929.1 165 5.4e-09 PREDICTED: uncharacterized protein LOC103310210 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.15678 BF_2 59.01 1.73 1712 584482886 AHJ09940.1 1070 9.4e-114 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- P26215 584 8.7e-59 Polygalacturonase OS=Cochliobolus carbonum GN=PGN1 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.15679 BF_2 128.99 4.02 1630 584482886 AHJ09940.1 1335 1.7e-144 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- P47180 695 1.1e-71 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.15680 BF_2 5.00 5.05 318 584482886 AHJ09940.1 377 4.0e-34 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- Q8NK99 164 8.2e-11 Probable endopolygalacturonase A OS=Aspergillus kawachii (strain NBRC 4308) GN=pgaA PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.15683 BF_2 116.00 3.08 1864 91094849 XP_971994.1 1723 1.9e-189 PREDICTED: probable queuine tRNA-ribosyltransferase [Tribolium castaneum]>gi|270006549|gb|EFA02997.1| hypothetical protein TcasGA2_TC010418 [Tribolium castaneum] 801376774 XM_012208846.1 151 9.61584e-71 PREDICTED: Atta cephalotes probable queuine tRNA-ribosyltransferase (LOC105627565), mRNA K00773 tgt, QTRT1 queuine tRNA-ribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00773 Q9VPY8 1286 3.8e-140 Probable queuine tRNA-ribosyltransferase OS=Drosophila melanogaster GN=Tgt PE=2 SV=1 PF01702 Queuine tRNA-ribosyltransferase GO:0006400//GO:0008616 tRNA modification//queuosine biosynthetic process GO:0008479 queuine tRNA-ribosyltransferase activity -- -- KOG3908 Queuine-tRNA ribosyltransferase Cluster-8309.15684 BF_2 628.06 8.06 3548 332375705 AEE62993.1 1349 8.7e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01619 deoC, DERA deoxyribose-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01619 Q9Y315 963 2.0e-102 Deoxyribose-phosphate aldolase OS=Homo sapiens GN=DERA PE=1 SV=2 PF00096//PF13465//PF01791//PF16622//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//DeoC/LacD family aldolase//zinc-finger C2H2-type//BTB/POZ domain -- -- GO:0046872//GO:0016829//GO:0005515 metal ion binding//lyase activity//protein binding -- -- KOG3981 Deoxyribose-phosphate aldolase Cluster-8309.15686 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15688 BF_2 12.00 0.39 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15690 BF_2 3.00 0.59 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15692 BF_2 2.00 2.69 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15694 BF_2 156.00 15.43 710 91084707 XP_969633.1 551 5.9e-54 PREDICTED: probable cytochrome P450 6a23 [Tribolium castaneum]>gi|270009245|gb|EFA05693.1| cytochrome P450 6BK13 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 357 7.6e-33 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0046872//GO:0016705 heme binding//oxidoreductase activity//iron ion binding//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.15695 BF_2 329.98 15.24 1193 741829513 AJA91072.1 1066 1.9e-113 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 793 3.5e-83 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00325//PF00067 Bacterial regulatory proteins, crp family//Cytochrome P450 GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0005506//GO:0020037//GO:0003677//GO:0016705 iron ion binding//heme binding//DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.15696 BF_2 36.26 0.32 5071 780175874 XP_011661330.1 388 3.4e-34 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 299 2.9e-25 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF12515//PF04851//PF13606//PF00023 Ca2+-ATPase N terminal autoinhibitory domain//Type III restriction enzyme, res subunit//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515//GO:0016787//GO:0003677//GO:0005524//GO:0005516 protein binding//hydrolase activity//DNA binding//ATP binding//calmodulin binding -- -- -- -- Cluster-8309.15697 BF_2 119.00 3.04 1924 642918606 XP_008200307.1 502 7.7e-48 PREDICTED: uncharacterized protein LOC103314890 isoform X1 [Tribolium castaneum]>gi|642918608|ref|XP_008200313.1| PREDICTED: uncharacterized protein LOC103314890 isoform X2 [Tribolium castaneum]>gi|270004660|gb|EFA01108.1| hypothetical protein TcasGA2_TC004033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15699 BF_2 1.00 1.01 318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15701 BF_2 134.00 12.89 722 852730176 XP_012882157.1 402 1.1e-36 PREDICTED: deoxycytidylate deaminase isoform X2 [Dipodomys ordii] -- -- -- -- -- K01493 comEB dCMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01493 Q5M9G0 389 1.5e-36 Deoxycytidylate deaminase OS=Rattus norvegicus GN=Dctd PE=2 SV=1 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region -- -- GO:0008270 zinc ion binding -- -- KOG3127 Deoxycytidylate deaminase Cluster-8309.15704 BF_2 36.96 0.35 4726 662195961 XP_008470989.1 757 5.1e-77 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02740 Colipase, C-terminal domain GO:0016042//GO:0007586 lipid catabolic process//digestion GO:0008047 enzyme activator activity GO:0005576 extracellular region -- -- Cluster-8309.15714 BF_2 105.76 1.83 2704 91077680 XP_974637.1 1934 9.7e-214 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.45151e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.5e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.15715 BF_2 62.99 1.04 2825 91077680 XP_974637.1 1934 1.0e-213 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.69875e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.6e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.15722 BF_2 10.84 0.35 1593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15729 BF_2 17.45 0.84 1152 189239721 XP_967180.2 308 1.4e-25 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 197 4.4e-14 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF04921//PF00320//PF01412 XAP5, circadian clock regulator//GATA zinc finger//Putative GTPase activating protein for Arf GO:0006355 regulation of transcription, DNA-templated GO:0005096//GO:0043565//GO:0008270//GO:0003700 GTPase activator activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.15730 BF_2 9.00 0.50 1043 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15731 BF_2 9.00 3.19 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15734 BF_2 5.00 0.37 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15735 BF_2 255.50 4.11 2889 642921918 XP_008192944.1 2013 7.1e-223 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15326 593 1.3e-59 Zinc finger MYND domain-containing protein 11 OS=Homo sapiens GN=ZMYND11 PE=1 SV=2 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.15736 BF_2 64.57 2.43 1399 91081173 XP_975583.1 439 1.1e-40 PREDICTED: mitochondrial 2-oxodicarboxylate carrier [Tribolium castaneum]>gi|270006043|gb|EFA02491.1| hypothetical protein TcasGA2_TC008186 [Tribolium castaneum] -- -- -- -- -- K15110 SLC25A21, ODC solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15110 Q8BZ09 287 2.0e-24 Mitochondrial 2-oxodicarboxylate carrier OS=Mus musculus GN=Slc25a21 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0754 Mitochondrial oxodicarboxylate carrier protein Cluster-8309.15738 BF_2 18.72 0.45 2028 642919283 XP_008191808.1 561 1.2e-54 PREDICTED: leucine-rich repeat protein soc-2 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJ07 185 1.9e-12 Protein phosphatase PHLPP-like protein OS=Drosophila melanogaster GN=Phlpp PE=3 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.15740 BF_2 114.00 7.55 919 91079510 XP_969537.1 904 8.9e-95 PREDICTED: methyl-CpG-binding domain protein 2 [Tribolium castaneum]>gi|270004424|gb|EFA00872.1| hypothetical protein TcasGA2_TC003775 [Tribolium castaneum] -- -- -- -- -- K11590 MBD2 methyl-CpG-binding domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11590 Q9UBB5 363 2.0e-33 Methyl-CpG-binding domain protein 2 OS=Homo sapiens GN=MBD2 PE=1 SV=1 PF01429 Methyl-CpG binding domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.15745 BF_2 73.00 2.16 1699 91084215 XP_968530.1 1374 5.2e-149 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZAI5 784 5.6e-82 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF08471//PF03015//PF01370//PF03435//PF01118//PF01073 Class II vitamin B12-dependent ribonucleotide reductase//Male sterility protein//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0006206//GO:0006144//GO:0009186//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0004748//GO:0051287//GO:0016491//GO:0003824//GO:0050897//GO:0016620//GO:0080019//GO:0016616//GO:0003854//GO:0050662 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//NAD binding//oxidoreductase activity//catalytic activity//cobalt ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-8309.15746 BF_2 43.28 0.77 2625 270004041 EFA00489.1 2621 2.0e-293 hypothetical protein TcasGA2_TC003349 [Tribolium castaneum] 642915621 XM_008192489.1 428 0 PREDICTED: Tribolium castaneum protein tramtrack, beta isoform (LOC660343), transcript variant X3, mRNA -- -- -- -- Q9W0K7 396 8.5e-37 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF05007//PF02796//PF05225//PF00651 Mannosyltransferase (PIG-M)//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//BTB/POZ domain GO:0006506//GO:0006310 GPI anchor biosynthetic process//DNA recombination GO:0003677//GO:0016758//GO:0005515//GO:0000150 DNA binding//transferase activity, transferring hexosyl groups//protein binding//recombinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.15753 BF_2 58.00 5.53 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15754 BF_2 97.51 4.56 1182 91078470 XP_968039.1 829 5.7e-86 PREDICTED: uncharacterized protein C16orf52 homolog A [Tribolium castaneum]>gi|270004014|gb|EFA00462.1| hypothetical protein TcasGA2_TC003319 [Tribolium castaneum] 766933212 XM_011500562.1 148 2.80561e-69 PREDICTED: Ceratosolen solmsi marchali uncharacterized protein C16orf52 homolog A (LOC105362993), transcript variant X2, mRNA K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q6GR34 493 2.1e-48 Uncharacterized protein C16orf52 homolog A OS=Xenopus laevis PE=2 SV=1 PF01006//PF01654 Hepatitis C virus non-structural protein NS4a//Cytochrome bd terminal oxidase subunit I GO:0016032 viral process -- -- GO:0016020//GO:0019012 membrane//virion -- -- Cluster-8309.15759 BF_2 107.23 1.36 3585 642913222 XP_008201445.1 1282 5.1e-138 PREDICTED: uncharacterized protein LOC664141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.1576 BF_2 8.00 0.36 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15760 BF_2 82.07 5.79 880 642912076 XP_008200791.1 562 3.9e-55 PREDICTED: U7 snRNA-associated Sm-like protein LSm11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T076 195 5.8e-14 U7 snRNA-associated Sm-like protein LSm11 OS=Xenopus laevis GN=lsm11 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15764 BF_2 35.00 4.32 626 91089671 XP_974390.1 344 5.2e-30 PREDICTED: protein lethal(2)essential for life [Tribolium castaneum]>gi|270012628|gb|EFA09076.1| hypothetical protein TcasGA2_TC006793 [Tribolium castaneum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 174 1.1e-11 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525 Alpha crystallin A chain, N terminal GO:0007423 sensory organ development GO:0005212 structural constituent of eye lens -- -- -- -- Cluster-8309.15765 BF_2 5.44 0.48 766 332377007 AEE63643.1 212 1.3e-14 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P02515 130 1.7e-06 Heat shock protein 22 OS=Drosophila melanogaster GN=Hsp22 PE=1 SV=4 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.15766 BF_2 40.56 4.41 672 332377007 AEE63643.1 212 1.1e-14 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P02515 130 1.5e-06 Heat shock protein 22 OS=Drosophila melanogaster GN=Hsp22 PE=1 SV=4 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.15767 BF_2 77.35 2.18 1774 642932840 XP_008197008.1 1441 9.3e-157 PREDICTED: uncharacterized protein LOC103314036 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.15772 BF_2 8.00 0.64 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15773 BF_2 4.00 0.35 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15774 BF_2 8.00 0.69 771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15775 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15776 BF_2 208.00 25.83 624 478256344 ENN76534.1 592 9.2e-59 hypothetical protein YQE_06985, partial [Dendroctonus ponderosae]>gi|546680774|gb|ERL90980.1| hypothetical protein D910_08322 [Dendroctonus ponderosae] -- -- -- -- -- K15171 SUPT4H1, SPT4 transcription elongation factor SPT4 http://www.genome.jp/dbget-bin/www_bget?ko:K15171 Q9TVQ5 480 3.7e-47 Transcription elongation factor SPT4 OS=Drosophila melanogaster GN=spt4 PE=1 SV=1 PF00105 Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3490 Transcription elongation factor SPT4 Cluster-8309.15784 BF_2 32.00 0.66 2315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15785 BF_2 9.34 0.84 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15787 BF_2 27.65 0.31 4054 190702373 ACE75266.1 762 1.2e-77 conserved hypothetical protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07817//PF13545//PF02796//PF08398//PF01498//PF12833//PF01418//PF04566//PF13404 GLE1-like protein//Crp-like helix-turn-helix domain//Helix-turn-helix domain of resolvase//Parvovirus coat protein VP1//Transposase//Helix-turn-helix domain//Helix-turn-helix domain, rpiR family//RNA polymerase Rpb2, domain 4//AsnC-type helix-turn-helix domain GO:0006206//GO:0006310//GO:0015074//GO:0006351//GO:0006313//GO:0006144//GO:0006355//GO:0016973 pyrimidine nucleobase metabolic process//DNA recombination//DNA integration//transcription, DNA-templated//transposition, DNA-mediated//purine nucleobase metabolic process//regulation of transcription, DNA-templated//poly(A)+ mRNA export from nucleus GO:0003677//GO:0043565//GO:0003700//GO:0003899//GO:0005198//GO:0000150 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA-directed RNA polymerase activity//structural molecule activity//recombinase activity GO:0005667//GO:0005643//GO:0005730//GO:0019028 transcription factor complex//nuclear pore//nucleolus//viral capsid -- -- Cluster-8309.15794 BF_2 35.84 0.62 2719 91083991 XP_975229.1 1974 2.2e-218 PREDICTED: origin recognition complex subunit 3 [Tribolium castaneum]>gi|270006709|gb|EFA03157.1| hypothetical protein TcasGA2_TC013076 [Tribolium castaneum] -- -- -- -- -- K02605 ORC3 origin recognition complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02605 Q9UBD5 982 9.8e-105 Origin recognition complex subunit 3 OS=Homo sapiens GN=ORC3 PE=1 SV=1 PF07034//PF07531//PF04421 Origin recognition complex (ORC) subunit 3 N-terminus//NHR1 homology to TAF//Mss4 protein GO:0006355//GO:0006260//GO:0043087//GO:0007264 regulation of transcription, DNA-templated//DNA replication//regulation of GTPase activity//small GTPase mediated signal transduction GO:0003700//GO:0005085//GO:0003677 transcription factor activity, sequence-specific DNA binding//guanyl-nucleotide exchange factor activity//DNA binding GO:0005667//GO:0005664 transcription factor complex//nuclear origin of replication recognition complex KOG2538 Origin recognition complex, subunit 3 Cluster-8309.15795 BF_2 54.94 3.56 933 91089041 XP_969722.1 348 2.7e-30 PREDICTED: EKC/KEOPS complex subunit Tprkb [Tribolium castaneum]>gi|270012398|gb|EFA08846.1| hypothetical protein TcasGA2_TC006547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y3C4 219 1.0e-16 EKC/KEOPS complex subunit TPRKB OS=Homo sapiens GN=TPRKB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15799 BF_2 11.00 0.47 1257 91095011 XP_969955.1 755 2.3e-77 PREDICTED: transcription initiation factor TFIID subunit 9 [Tribolium castaneum]>gi|270015430|gb|EFA11878.1| hypothetical protein TcasGA2_TC004292 [Tribolium castaneum] -- -- -- -- -- K03133 TAF9B, TAF9 transcription initiation factor TFIID subunit 9B http://www.genome.jp/dbget-bin/www_bget?ko:K03133 Q27272 425 1.8e-40 Transcription initiation factor TFIID subunit 9 OS=Drosophila melanogaster GN=e(y)1 PE=1 SV=1 PF02291 Transcription initiation factor IID, 31kD subunit GO:0006352 DNA-templated transcription, initiation -- -- -- -- KOG3334 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) Cluster-8309.15802 BF_2 1.00 0.43 382 641670349 XP_008185160.1 171 3.7e-10 PREDICTED: piggyBac transposable element-derived protein 3-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15806 BF_2 3.00 1.45 371 -- -- -- -- -- 146747423 EF564346.1 93 3.10445e-39 Sesbania drummondii auxin-repressed protein mRNA, complete cds -- -- -- -- Q05349 220 3.0e-17 Auxin-repressed 12.5 kDa protein OS=Fragaria ananassa PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15807 BF_2 404.64 3.16 5636 642913872 XP_008201198.1 1400 1.7e-151 PREDICTED: SH3 domain-containing kinase-binding protein 1 isoform X2 [Tribolium castaneum] 23589286 AK116679.1 38 1.92832e-07 Ciona intestinalis cDNA, clone:cieg003e24, full insert sequence K12470 SH3KBP1, CIN85 SH3 domain-containing kinase-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12470 Q925Q9 306 5.0e-26 SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus GN=Sh3kbp1 PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4348 Adaptor protein CMS/SETA Cluster-8309.15808 BF_2 18.45 0.50 1835 642916483 XP_966412.2 314 4.6e-26 PREDICTED: pickpocket protein 28-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.15809 BF_2 36.39 0.97 1863 546672758 ERL84523.1 2050 2.4e-227 hypothetical protein D910_01953 [Dendroctonus ponderosae] 642928406 XM_966741.2 233 2.50727e-116 PREDICTED: Tribolium castaneum cysteine sulfinic acid decarboxylase-like (LOC660516), mRNA K01580 E4.1.1.15, gadB, gadA, GAD glutamate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01580 Q0VCA1 1242 4.8e-135 Glutamate decarboxylase 1 OS=Bos taurus GN=GAD1 PE=2 SV=1 PF01276//PF00155//PF00282//PF01212//PF05889 Orn/Lys/Arg decarboxylase, major domain//Aminotransferase class I and II//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GO:0006520//GO:0009058//GO:0019752 cellular amino acid metabolic process//biosynthetic process//carboxylic acid metabolic process GO:0016829//GO:0030170//GO:0016831//GO:0016740//GO:0003824 lyase activity//pyridoxal phosphate binding//carboxy-lyase activity//transferase activity//catalytic activity -- -- KOG0629 Glutamate decarboxylase and related proteins Cluster-8309.15812 BF_2 25.34 0.92 1438 91082063 XP_972067.1 574 2.6e-56 PREDICTED: glucose-induced degradation protein 8 homolog [Tribolium castaneum]>gi|270007278|gb|EFA03726.1| hypothetical protein TcasGA2_TC013835 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PC55 374 1.6e-34 Glucose-induced degradation protein 8 homolog OS=Danio rerio GN=gid8 PE=2 SV=1 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG2659 LisH motif-containing protein Cluster-8309.15813 BF_2 292.66 16.55 1027 91082063 XP_972067.1 1036 4.9e-110 PREDICTED: glucose-induced degradation protein 8 homolog [Tribolium castaneum]>gi|270007278|gb|EFA03726.1| hypothetical protein TcasGA2_TC013835 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKQ7 731 4.7e-76 Glucose-induced degradation protein 8 homolog OS=Gallus gallus GN=GID8 PE=2 SV=1 PF08513//PF01191 LisH//RNA polymerase Rpb5, C-terminal domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005730 nucleolus KOG2659 LisH motif-containing protein Cluster-8309.15815 BF_2 8.68 0.48 1046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06330 Trichodiene synthase (TRI5) GO:0016114//GO:0016106 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process GO:0045482 trichodiene synthase activity -- -- -- -- Cluster-8309.15816 BF_2 13.00 22.14 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15817 BF_2 8.00 2.09 447 325303594 DAA34560.1 364 1.8e-32 TPA_exp: malate dehydrogenase [Amblyomma variegatum] 116632972 CT832776.1 447 0 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCRA117E21, full insert sequence K00025 MDH1 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00025 Q7XDC8 563 6.2e-57 Malate dehydrogenase, cytoplasmic OS=Oryza sativa subsp. japonica GN=Os10g0478200 PE=1 SV=3 PF00056//PF01073//PF03606 lactate/malate dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//C4-dicarboxylate anaerobic carrier GO:0008210//GO:0055114//GO:0006694//GO:0008209//GO:0008207 estrogen metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0016021 integral component of membrane KOG1496 Malate dehydrogenase Cluster-8309.1582 BF_2 90.12 3.39 1399 91087331 XP_975597.1 780 3.3e-80 PREDICTED: TM2 domain-containing protein CG10795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W2H1 643 1.0e-65 TM2 domain-containing protein CG10795 OS=Drosophila melanogaster GN=CG10795 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4272 Predicted GTP-binding protein Cluster-8309.15823 BF_2 21.00 3.08 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15826 BF_2 5.00 0.33 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15829 BF_2 22.51 0.34 3085 546679741 ERL90152.1 1446 4.3e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BKN5 456 1.1e-43 Gamma-tubulin complex component 5 OS=Mus musculus GN=Tubgcp5 PE=2 SV=2 PF04505//PF04130 Interferon-induced transmembrane protein//Spc97 / Spc98 family GO:0009607//GO:0090063//GO:0000226 response to biotic stimulus//positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0016021//GO:0005815//GO:0000922 integral component of membrane//microtubule organizing center//spindle pole -- -- Cluster-8309.15831 BF_2 26.30 0.43 2851 642914172 XP_008201574.1 1953 6.4e-216 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 958 6.2e-102 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738 Dienelactone hydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.15836 BF_2 87.00 2.08 2037 21622583 CAD13268.2 1015 2.7e-107 cytochrome oxidase subunit III [Manis tetradactyla] 545758161 KF161635.1 2037 0 Homo sapiens isolate 124224 mitochondrion, complete genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 P00414 1011 3.2e-108 Cytochrome c oxidase subunit 3 OS=Homo sapiens GN=MT-CO3 PE=1 SV=2 PF00119//PF00895//PF04834 ATP synthase A chain//ATP synthase protein 8//Early E3 14.5 kDa protein GO:0009966//GO:0015986//GO:0015992 regulation of signal transduction//ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276//GO:0016021 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-8309.15838 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15842 BF_2 130.56 2.46 2511 332373864 AEE62073.1 1584 3.4e-173 unknown [Dendroctonus ponderosae]>gi|546671405|gb|ERL83730.1| hypothetical protein D910_00943 [Dendroctonus ponderosae]>gi|546673035|gb|ERL84721.1| hypothetical protein D910_02146 [Dendroctonus ponderosae]>gi|546675548|gb|ERL86721.1| hypothetical protein D910_04127 [Dendroctonus ponderosae] 817192520 XM_012416276.1 150 4.68189e-70 PREDICTED: Orussus abietinus uncharacterized LOC105695047 (LOC105695047), transcript variant X5, mRNA K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 P48544 859 1.7e-90 G protein-activated inward rectifier potassium channel 4 OS=Homo sapiens GN=KCNJ5 PE=1 SV=2 PF03845//PF01007//PF08038 Spore germination protein//Inward rectifier potassium channel//TOM7 family GO:0009847//GO:0006813//GO:0030150 spore germination//potassium ion transport//protein import into mitochondrial matrix GO:0005242 inward rectifier potassium channel activity GO:0016021//GO:0008076//GO:0005742 integral component of membrane//voltage-gated potassium channel complex//mitochondrial outer membrane translocase complex KOG3827 Inward rectifier K+ channel Cluster-8309.15845 BF_2 82.00 2.01 1998 91092446 XP_969288.1 1909 5.6e-211 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270004733|gb|EFA01181.1| hypothetical protein TcasGA2_TC010506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9U539 806 1.8e-84 Organic cation transporter 1 OS=Caenorhabditis elegans GN=oct-1 PE=1 SV=3 PF00825//PF12106//PF07690//PF00380//PF00083 Ribonuclease P//Colicin C terminal ribonuclease domain//Major Facilitator Superfamily//Ribosomal protein S9/S16//Sugar (and other) transporter GO:0042254//GO:0051252//GO:0008033//GO:0055085//GO:0006412 ribosome biogenesis//regulation of RNA metabolic process//tRNA processing//transmembrane transport//translation GO:0003735//GO:0022857//GO:0004526//GO:0000049//GO:0004540 structural constituent of ribosome//transmembrane transporter activity//ribonuclease P activity//tRNA binding//ribonuclease activity GO:0005840//GO:0016021//GO:0030677 ribosome//integral component of membrane//ribonuclease P complex KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.15848 BF_2 8.13 0.41 1124 646719797 KDR21783.1 608 2.3e-60 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 559 4.5e-56 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF00956//PF03938//PF07352//PF05384//PF02990 Nucleosome assembly protein (NAP)//Outer membrane protein (OmpH-like)//Bacteriophage Mu Gam like protein//Sensor protein DegS//Endomembrane protein 70 GO:0007165//GO:0042262//GO:0006334 signal transduction//DNA protection//nucleosome assembly GO:0051082//GO:0016301//GO:0003690 unfolded protein binding//kinase activity//double-stranded DNA binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.15849 BF_2 18.33 0.65 1470 646719797 KDR21783.1 645 1.5e-64 Protein SET [Zootermopsis nevadensis] -- -- -- -- -- K11290 SET, TAF1, I2PP2A template-activating factor I http://www.genome.jp/dbget-bin/www_bget?ko:K11290 P53997 596 3.1e-60 Protein SET OS=Drosophila melanogaster GN=Set PE=1 SV=2 PF00956//PF07352 Nucleosome assembly protein (NAP)//Bacteriophage Mu Gam like protein GO:0006334//GO:0042262 nucleosome assembly//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG1508 DNA replication factor/protein phosphatase inhibitor SET/SPR-2 Cluster-8309.15852 BF_2 3.00 2.07 342 801404696 XP_012061925.1 140 1.3e-06 PREDICTED: fatty acid synthase-like, partial [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.15853 BF_2 2.00 0.50 454 815826187 XP_012234475.1 213 5.9e-15 PREDICTED: LOW QUALITY PROTEIN: fatty acid synthase-like [Linepithema humile] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 158 5.8e-10 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.15861 BF_2 23.00 6.08 445 45269125 AAS55948.1 147 2.6e-07 cystatin-2 precursor [Ornithodoros moubata] -- -- -- -- -- -- -- -- -- B1P1J3 127 2.2e-06 Cystatin-1 OS=Chilobrachys guangxiensis PE=2 SV=1 PF00031//PF03823 Cystatin domain//Neurokinin B GO:0007217 tachykinin receptor signaling pathway GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.15865 BF_2 11.51 0.49 1267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15868 BF_2 22.31 0.44 2414 270013391 EFA09839.1 2883 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 462302184 APGK01050321.1 89 3.65408e-36 Dendroctonus ponderosae Seq01050331, whole genome shotgun sequence -- -- -- -- P21783 358 2.0e-32 Neurogenic locus notch homolog protein 1 OS=Xenopus laevis GN=notch1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.15869 BF_2 59.63 5.17 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15870 BF_2 23.00 1.85 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15871 BF_2 9.72 0.53 1048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15874 BF_2 9.99 1.88 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15877 BF_2 71.10 0.77 4146 642912669 XP_008200957.1 3277 0.0e+00 PREDICTED: aminopeptidase N [Tribolium castaneum] 556957556 XM_005989784.1 42 8.45756e-10 PREDICTED: Latimeria chalumnae alanyl (membrane) aminopeptidase (ANPEP), transcript variant X3, mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1579 8.9e-174 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.1588 BF_2 10.00 1.59 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05024 N-acetylglucosaminyl transferase component (Gpi1) GO:0006506 GPI anchor biosynthetic process GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.15880 BF_2 169.57 1.84 4152 478253041 ENN73421.1 2062 2.1e-228 hypothetical protein YQE_09983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08651 DASH complex subunit Duo1 GO:0007067 mitotic nuclear division -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle -- -- Cluster-8309.15886 BF_2 1.12 0.87 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15891 BF_2 17.00 1.31 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15895 BF_2 0.90 2.21 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.15898 BF_2 62.97 1.98 1619 546679463 ERL89927.1 698 1.2e-70 hypothetical protein D910_07286 [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 O95425 451 2.2e-43 Supervillin OS=Homo sapiens GN=SVIL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15899 BF_2 16.99 0.56 1559 91087949 XP_972541.1 906 8.9e-95 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 A2AGA4 406 3.5e-38 Rhomboid-related protein 2 OS=Mus musculus GN=Rhbdl2 PE=1 SV=1 PF01694//PF13202//PF13405//PF13833//PF00036//PF13499 Rhomboid family//EF hand//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509//GO:0004252 calcium ion binding//serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.15901 BF_2 5.00 0.32 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15903 BF_2 84.00 2.06 1989 635037386 XP_007994139.1 383 5.0e-34 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 737-like [Chlorocebus sabaeus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q68DY1 375 1.7e-34 Zinc finger protein 626 OS=Homo sapiens GN=ZNF626 PE=2 SV=2 PF07776//PF16622//PF13912//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.15914 BF_2 110.09 2.17 2410 332376993 AEE63636.1 2320 1.5e-258 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14304 NUP85 nuclear pore complex protein Nup85 http://www.genome.jp/dbget-bin/www_bget?ko:K14304 Q8R480 1036 4.8e-111 Nuclear pore complex protein Nup85 OS=Mus musculus GN=Nup85 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15915 BF_2 4.00 1.70 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15916 BF_2 121.06 1.02 5252 642929943 XP_008196036.1 680 4.8e-68 PREDICTED: microtubule-associated protein futsch-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q767L8 268 1.2e-21 Mediator of DNA damage checkpoint protein 1 OS=Sus scrofa GN=MDC1 PE=3 SV=1 PF01734//PF00498 Patatin-like phospholipase//FHA domain GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.15918 BF_2 8.00 0.87 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04584 Poxvirus A28 family GO:0016032 viral process -- -- GO:0019031 viral envelope -- -- Cluster-8309.15919 BF_2 2.00 1.98 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15920 BF_2 179.27 4.95 1802 91090546 XP_971052.1 992 1.1e-104 PREDICTED: tumor protein p63-regulated gene 1-like protein isoform X1 [Tribolium castaneum]>gi|270013883|gb|EFA10331.1| hypothetical protein TcasGA2_TC012549 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0D9 280 1.6e-23 Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens GN=TPRG1L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15924 BF_2 3.35 1.55 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15926 BF_2 14.00 1.51 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1593 BF_2 12.00 0.48 1331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15930 BF_2 74.00 1.80 2008 642937984 XP_008199157.1 282 2.6e-22 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15934 BF_2 9.00 0.36 1339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15935 BF_2 6.00 0.52 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15936 BF_2 10.00 3.25 415 -- -- -- -- -- 657967729 XM_008377335.1 99 1.62088e-42 PREDICTED: Malus x domestica dnaJ protein homolog (LOC103438785), mRNA -- -- -- -- Q04960 193 4.6e-14 DnaJ protein homolog OS=Cucumis sativus GN=DNAJ1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.15938 BF_2 116.01 2.16 2534 768440289 XP_011561812.1 823 6.1e-85 PREDICTED: uncharacterized protein LOC105391939 isoform X2 [Plutella xylostella] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 Q1JPB9 301 8.5e-26 Group 3 secretory phospholipase A2 OS=Bos taurus GN=PLA2G3 PE=2 SV=1 PF12678//PF00616 RING-H2 zinc finger//GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.15939 BF_2 64.84 1.21 2530 768440291 XP_011561813.1 652 4.1e-65 PREDICTED: uncharacterized protein LOC105391939 isoform X3 [Plutella xylostella] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P16354 302 6.5e-26 Phospholipase A2 isozymes PA3A/PA3B/PA5 OS=Heloderma suspectum PE=1 SV=3 PF12678//PF00616 RING-H2 zinc finger//GTPase-activator protein for Ras-like GTPase GO:0043087 regulation of GTPase activity GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.15942 BF_2 32.74 0.53 2885 115443558 YP_778577.1 970 6.2e-102 cytochrome b6 [Bigelowiella natans]>gi|115443565|ref|YP_778584.1| cytochrome b6 [Bigelowiella natans]>gi|122246280|sp|Q06J43.1|CYB6_BIGNA RecName: Full=Cytochrome b6 (chloroplast) [Bigelowiella natans]>gi|110810203|gb|ABG91409.1| cytochrome b6 [Bigelowiella natans]>gi|110810210|gb|ABG91416.1| cytochrome b6 [Bigelowiella natans] 761231605 KM881639.1 2885 0 Oryza glaberrima isolate 101328 chloroplast, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 P0C316 1116 3.0e-120 Cytochrome b6 OS=Oryza sativa subsp. indica GN=petB PE=3 SV=1 PF00032//PF13631//PF01292//PF00033 Cytochrome b(C-terminal)/b6/petD//Cytochrome b(N-terminal)/b6/petB//Prokaryotic cytochrome b561//Cytochrome b/b6/petB GO:0022904//GO:0015979//GO:0006118 respiratory electron transport chain//photosynthesis//obsolete electron transport GO:0045158//GO:0016491//GO:0020037//GO:0005506//GO:0009055 electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity//oxidoreductase activity//heme binding//iron ion binding//electron carrier activity GO:0016021//GO:0009535//GO:0016020 integral component of membrane//chloroplast thylakoid membrane//membrane KOG4663 Cytochrome b Cluster-8309.15951 BF_2 2.00 0.47 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15953 BF_2 2.00 0.83 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15959 BF_2 1.00 36.54 204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15961 BF_2 119.66 1.34 4016 91083749 XP_971342.1 2203 9.2e-245 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1116 4.2e-120 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.15963 BF_2 35.27 1.13 1598 91086847 XP_974260.1 857 4.4e-89 PREDICTED: BSD domain-containing protein 1-B [Tribolium castaneum]>gi|270010460|gb|EFA06908.1| hypothetical protein TcasGA2_TC009857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BJ78 312 2.8e-27 BSD domain-containing protein 1 OS=Xenopus tropicalis GN=bsdc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2690 Uncharacterized conserved protein, contains BSD domain Cluster-8309.15965 BF_2 20.23 1.30 938 270010209 EFA06657.1 1046 3.1e-111 hypothetical protein TcasGA2_TC009583 [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q01583 466 2.3e-45 Diacylglycerol kinase 1 OS=Drosophila melanogaster GN=Dgk PE=2 SV=5 PF13202//PF13833//PF00036//PF13405//PF13499 EF hand//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.15968 BF_2 70.00 3.17 1211 189242406 XP_001810193.1 1389 6.8e-151 PREDICTED: peptidyl-prolyl cis-trans isomerase E [Tribolium castaneum]>gi|270016278|gb|EFA12724.1| hypothetical protein TcasGA2_TC002359 [Tribolium castaneum] 820862831 XM_012492661.1 108 4.95164e-47 PREDICTED: Apis florea peptidyl-prolyl cis-trans isomerase-like (LOC100866709), mRNA K09564 PPIE peptidyl-prolyl isomerase E (cyclophilin E) http://www.genome.jp/dbget-bin/www_bget?ko:K09564 A4FV72 1124 1.5e-121 Peptidyl-prolyl cis-trans isomerase E OS=Bos taurus GN=PPIE PE=2 SV=1 PF00076//PF16367//PF00160 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003676//GO:0003755//GO:0003723//GO:0000166 nucleic acid binding//peptidyl-prolyl cis-trans isomerase activity//RNA binding//nucleotide binding -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.15970 BF_2 5.00 0.56 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07243 Phlebovirus glycoprotein G1 -- -- -- -- GO:0019012//GO:0016021 virion//integral component of membrane -- -- Cluster-8309.15971 BF_2 36.79 0.71 2453 546680487 ERL90753.1 1333 4.3e-144 hypothetical protein D910_08100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Z136 313 3.3e-27 Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 PF02465//PF06005 Flagellar hook-associated protein 2 N-terminus//Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737//GO:0009424 cytoplasm//bacterial-type flagellum hook KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.15974 BF_2 31.41 0.46 3146 478260277 ENN80029.1 3713 0.0e+00 hypothetical protein YQE_03506, partial [Dendroctonus ponderosae] 749790992 XM_011150385.1 92 1.0264e-37 PREDICTED: Harpegnathos saltator DNA replication licensing factor MCM4 (LOC105188757), transcript variant X3, mRNA K02212 MCM4, CDC54 DNA replication licensing factor MCM4 http://www.genome.jp/dbget-bin/www_bget?ko:K02212 Q26454 3288 0.0e+00 DNA replication licensing factor MCM4 OS=Drosophila melanogaster GN=dpa PE=1 SV=2 PF04055//PF07726//PF00493//PF07837//PF05460//PF03648//PF07728//PF13545//PF05669//PF00158//PF00004 Radical SAM superfamily//ATPase family associated with various cellular activities (AAA)//MCM2/3/5 family//Formiminotransferase domain, N-terminal subdomain//Origin recognition complex subunit 6 (ORC6)//Glycosyl hydrolase family 67 N-terminus//AAA domain (dynein-related subfamily)//Crp-like helix-turn-helix domain//SOH1//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA) GO:0006260//GO:0006355//GO:0005975//GO:0045493//GO:0008152 DNA replication//regulation of transcription, DNA-templated//carbohydrate metabolic process//xylan catabolic process//metabolic process GO:0016887//GO:0051536//GO:0016740//GO:0046559//GO:0005524//GO:0008134//GO:0005542//GO:0001104//GO:0003677//GO:0003824 ATPase activity//iron-sulfur cluster binding//transferase activity//alpha-glucuronidase activity//ATP binding//transcription factor binding//folic acid binding//RNA polymerase II transcription cofactor activity//DNA binding//catalytic activity GO:0016592//GO:0005664//GO:0005667 mediator complex//nuclear origin of replication recognition complex//transcription factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.1598 BF_2 2.39 1.75 338 642934331 XP_008198605.1 276 2.2e-22 PREDICTED: tripartite motif-containing protein 2 isoform X3 [Tribolium castaneum] 817086197 XM_012410395.1 50 2.24355e-15 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15981 BF_2 42.74 0.76 2642 642912777 XP_008201245.1 612 1.9e-60 PREDICTED: cephalothorax isoform X1 [Tribolium castaneum] 642912776 XM_008203023.1 231 4.62551e-115 PREDICTED: Tribolium castaneum cephalothorax (Cx), transcript variant X1, mRNA K09304 HOX_4 homeobox protein HoxA/B/C/D4 http://www.genome.jp/dbget-bin/www_bget?ko:K09304 P09077 465 8.5e-45 Homeotic protein Sex combs reduced OS=Drosophila melanogaster GN=Scr PE=1 SV=5 PF00046//PF09726 Homeobox domain//Transmembrane protein -- -- GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.15982 BF_2 81.37 1.37 2768 86515396 NP_001034523.1 633 7.2e-63 cephalothorax [Tribolium castaneum]>gi|13241681|gb|AAK16422.1|AF321227_2 Scr [Tribolium castaneum]>gi|270002805|gb|EEZ99252.1| sex combs reduced [Tribolium castaneum] 86515395 NM_001039434.1 286 1.29131e-145 Tribolium castaneum cephalothorax (Cx), mRNA K09311 ANTP Antp family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09311 P09077 601 1.5e-60 Homeotic protein Sex combs reduced OS=Drosophila melanogaster GN=Scr PE=1 SV=5 PF09726//PF00046 Transmembrane protein//Homeobox domain GO:0007275//GO:0006355 multicellular organismal development//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016021 transcription factor complex//nucleus//integral component of membrane -- -- Cluster-8309.15985 BF_2 35.66 0.60 2771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15986 BF_2 213.00 8.20 1374 332375817 AEE63049.1 943 4.0e-99 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14823 EBP2, EBNA1BP2 rRNA-processing protein EBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14823 Q9V9Z9 667 1.7e-68 Probable rRNA-processing protein EBP2 homolog OS=Drosophila melanogaster GN=CG1542 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3080 Nucleolar protein-like/EBNA1-binding protein Cluster-8309.1599 BF_2 7.61 0.31 1331 642917708 XP_008191339.1 552 8.5e-54 PREDICTED: insulin-like growth factor-binding protein 7 [Tribolium castaneum]>gi|270004468|gb|EFA00916.1| hypothetical protein TcasGA2_TC003822 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.15996 BF_2 27.00 0.57 2253 641657886 XP_008180508.1 812 1.0e-83 PREDICTED: zinc finger MYM-type protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q5SVZ6 297 2.2e-25 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 PF04088 Peroxin 13, N-terminal region GO:0016560 protein import into peroxisome matrix, docking -- -- GO:0005777//GO:0016021 peroxisome//integral component of membrane -- -- Cluster-8309.15997 BF_2 7.00 0.52 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15998 BF_2 8.00 0.57 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.15999 BF_2 6.00 1.87 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1600 BF_2 8.39 1.30 556 642917708 XP_008191339.1 294 2.9e-24 PREDICTED: insulin-like growth factor-binding protein 7 [Tribolium castaneum]>gi|270004468|gb|EFA00916.1| hypothetical protein TcasGA2_TC003822 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region -- -- Cluster-8309.16000 BF_2 161.19 0.57 12021 642921923 XP_008192946.1 150 3.2e-06 PREDICTED: eukaryotic translation initiation factor 4 gamma 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17122 Zinc-finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.16001 BF_2 3.00 0.67 475 123471670 XP_001319033.1 317 5.4e-27 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121901807|gb|EAY06810.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q9VUX2 252 7.6e-21 E3 ubiquitin-protein ligase mind-bomb OS=Drosophila melanogaster GN=mib1 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.16003 BF_2 39.00 10.31 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16004 BF_2 73.07 2.31 1611 642921705 XP_008194745.1 1045 7.0e-111 PREDICTED: peroxisome biogenesis factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P24392 380 3.7e-35 Peroxisome biogenesis factor 2 OS=Rattus norvegicus GN=Pex2 PE=2 SV=1 PF16685//PF13639//PF14634//PF00097 zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0061630//GO:0005515//GO:0046872//GO:0008270 ubiquitin protein ligase activity//protein binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.16009 BF_2 7.00 3.05 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16012 BF_2 5.00 1.33 444 160550189 ABX44799.1 402 7.0e-37 putative 40S ribosomal protein RPS27 [Flustra foliacea] -- -- -- -- -- K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 Q2KHT7 377 2.3e-35 40S ribosomal protein S27 OS=Bos taurus GN=RPS27 PE=3 SV=3 PF01667 Ribosomal protein S27 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.16016 BF_2 73.00 6.99 724 478262795 ENN81312.1 636 8.4e-64 hypothetical protein YQE_02280, partial [Dendroctonus ponderosae]>gi|546672916|gb|ERL84632.1| hypothetical protein D910_02060 [Dendroctonus ponderosae] -- -- -- -- -- K05019 CLNS1A chloride channel, nucleotide-sensitive, 1A http://www.genome.jp/dbget-bin/www_bget?ko:K05019 P54106 247 4.4e-20 Methylosome subunit pICln OS=Xenopus laevis GN=clns1a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16017 BF_2 474.00 3.70 5641 642939136 XP_008201178.1 523 8.3e-50 PREDICTED: uncharacterized protein LOC103315105 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q505D1 437 3.2e-41 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF06324//PF00023 Ankyrin repeat//Pigment-dispersing hormone (PDH)//Ankyrin repeat GO:0009416//GO:0007165 response to light stimulus//signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.16018 BF_2 18.00 1.72 725 724908769 XP_010378801.1 245 1.8e-18 PREDICTED: fibroblast growth factor receptor 2 isoform X3 [Rhinopithecus roxellana] 254553324 NG_012449.1 676 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 211 6.6e-16 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16022 BF_2 95.16 1.14 3783 642910693 XP_008200063.1 3431 0.0e+00 PREDICTED: neurogenic locus protein delta [Tribolium castaneum]>gi|270014506|gb|EFA10954.1| hypothetical protein TcasGA2_TC004114 [Tribolium castaneum] 642910692 XM_008201841.1 761 0 PREDICTED: Tribolium castaneum neurogenic locus protein delta (LOC658619), mRNA K06051 DLL delta http://www.genome.jp/dbget-bin/www_bget?ko:K06051 Q9IAT6 1432 9.0e-157 Delta-like protein C OS=Danio rerio GN=dlc PE=2 SV=1 PF07645//PF00008//PF01414//PF07657 Calcium-binding EGF domain//EGF-like domain//Delta serrate ligand//N terminus of Notch ligand GO:0007154//GO:0007219//GO:0007275 cell communication//Notch signaling pathway//multicellular organismal development GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.16024 BF_2 95.00 1.45 3020 91087773 XP_975069.1 886 3.6e-92 PREDICTED: uncharacterized protein LOC663949 [Tribolium castaneum]>gi|270010747|gb|EFA07195.1| hypothetical protein TcasGA2_TC010201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.16034 BF_2 126.53 1.11 5052 642917061 XP_008191104.1 4043 0.0e+00 PREDICTED: roundabout homolog 2 [Tribolium castaneum] 642917060 XM_008192882.1 512 0 PREDICTED: Tribolium castaneum roundabout (LOC655427), mRNA K06754 ROBO2 roundabout, axon guidance receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06754 Q9HCK4 1513 4.9e-166 Roundabout homolog 2 OS=Homo sapiens GN=ROBO2 PE=1 SV=2 PF07578//PF16656//PF00041//PF13895 Lipid A Biosynthesis N-terminal domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0019497//GO:0009245//GO:0006771 hexachlorocyclohexane metabolic process//lipid A biosynthetic process//riboflavin metabolic process GO:0005515//GO:0008915//GO:0046872//GO:0003993 protein binding//lipid-A-disaccharide synthase activity//metal ion binding//acid phosphatase activity -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.16035 BF_2 3.00 0.89 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16037 BF_2 34.00 1.61 1169 262401027 ACY66416.1 599 2.6e-59 cytochrome c oxidase polypeptide IV [Scylla paramamosain] 262401026 FJ774694.1 343 1.10452e-177 Scylla paramamosain cytochrome c oxidase polypeptide IV mRNA, partial cds K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 337 2.6e-30 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.16038 BF_2 14.40 0.68 1176 260831005 XP_002610450.1 225 6.2e-16 hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae]>gi|229295816|gb|EEN66460.1| hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.16039 BF_2 7.50 0.42 1039 260831005 XP_002610450.1 157 4.2e-08 hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae]>gi|229295816|gb|EEN66460.1| hypothetical protein BRAFLDRAFT_124265 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.16040 BF_2 5.00 0.81 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16041 BF_2 42.78 0.75 2664 91088919 XP_973208.1 1394 3.9e-151 PREDICTED: protein asunder [Tribolium castaneum]>gi|270012357|gb|EFA08805.1| hypothetical protein TcasGA2_TC006499 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JHB4 825 1.5e-86 Protein asunder OS=Drosophila grimshawi GN=asun PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3711 Uncharacterized conserved protein Cluster-8309.16042 BF_2 245.33 4.82 2416 91088919 XP_973208.1 2763 6.4e-310 PREDICTED: protein asunder [Tribolium castaneum]>gi|270012357|gb|EFA08805.1| hypothetical protein TcasGA2_TC006499 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8QZV7 1425 3.7e-156 Protein asunder homolog OS=Mus musculus GN=Asun PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3711 Uncharacterized conserved protein Cluster-8309.16043 BF_2 25.56 0.41 2895 642938194 XP_008191102.1 334 3.5e-28 PREDICTED: uncharacterized protein LOC103312382 isoform X1 [Tribolium castaneum]>gi|270016585|gb|EFA13031.1| hypothetical protein TcasGA2_TC010561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16046 BF_2 200.39 5.43 1831 91094103 XP_967297.1 1683 8.3e-185 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBY7 1085 7.5e-117 Trafficking protein particle complex subunit 13 OS=Danio rerio GN=trappc13 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.16049 BF_2 173.00 22.98 602 -- -- -- -- -- 32974582 AK064564.1 584 0 Oryza sativa Japonica Group cDNA clone:002-112-D02, full insert sequence -- -- -- -- P60118 157 1.0e-09 ATP synthase subunit 9, mitochondrial OS=Petunia hybrida GN=ATP9 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.16050 BF_2 58.00 6.70 649 -- -- -- -- -- 102567956 DQ645539.1 646 0 Zea mays subsp. parviglumis mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16051 BF_2 212.32 1.03 8905 546675135 ERL86379.1 900 2.5e-93 hypothetical protein D910_03787, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N2G6 656 2.0e-66 Zinc finger CCHC domain-containing protein 24 OS=Homo sapiens GN=ZCCHC24 PE=1 SV=1 PF00098//PF05495 Zinc knuckle//CHY zinc finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.16053 BF_2 79.02 3.42 1254 91078614 XP_967493.1 1120 1.1e-119 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 238 2.77807e-119 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 O43752 576 5.4e-58 Syntaxin-6 OS=Homo sapiens GN=STX6 PE=1 SV=1 PF05478//PF09177//PF05739//PF04871//PF04108 Prominin//Syntaxin 6, N-terminal//SNARE domain//Uso1 / p115 like vesicle tethering protein, C terminal region//Autophagy protein Apg17 GO:0006914//GO:0006886//GO:0048193//GO:0015031 autophagy//intracellular protein transport//Golgi vesicle transport//protein transport GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0016021//GO:0016020//GO:0005737 integral component of membrane//membrane//cytoplasm KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.16060 BF_2 1.00 0.33 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16061 BF_2 15.00 1.37 744 324975476 ADY62663.1 429 8.7e-40 putative LIM protein [Hottentotta judaicus] -- -- -- -- -- K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 P53777 264 4.8e-22 Muscle LIM protein 1 OS=Drosophila melanogaster GN=Mlp60A PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.16065 BF_2 2.00 0.67 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16067 BF_2 71.41 5.76 806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16068 BF_2 8.08 0.34 1269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1608 BF_2 6.00 0.34 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16082 BF_2 46.33 3.30 875 861436651 XP_012927760.1 549 1.2e-53 PREDICTED: POC1 centriolar protein homolog B isoform X1 [Heterocephalus glaber] -- -- -- -- -- K16482 POC1 centriolar protein POC1 http://www.genome.jp/dbget-bin/www_bget?ko:K16482 Q7ZVF0 547 8.7e-55 POC1 centriolar protein homolog A OS=Danio rerio GN=poc1a PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.16087 BF_2 2.00 0.46 468 642922767 XP_008193317.1 147 2.7e-07 PREDICTED: spermatogenesis-associated protein 13-like isoform X2 [Tribolium castaneum]>gi|642922769|ref|XP_008193318.1| PREDICTED: spermatogenesis-associated protein 13-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.16089 BF_2 12.00 0.48 1326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16091 BF_2 141.47 10.21 867 546684171 ERL93876.1 426 2.3e-39 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- K15053 CHMP7 charged multivesicular body protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15053 -- -- -- -- PF03357//PF04508 Snf7//Viral A-type inclusion protein repeat GO:0007034//GO:0016032 vacuolar transport//viral process -- -- -- -- -- -- Cluster-8309.16098 BF_2 113.00 2.25 2391 549438523 AGX25150.1 2410 5.4e-269 serine proteinase inhibitor, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- A2ASQ1 315 1.9e-27 Agrin OS=Mus musculus GN=Agrn PE=1 SV=1 PF02456//PF00050//PF07648 Adenovirus IVa2 protein//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0019083 viral transcription GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.16101 BF_2 7.00 1.05 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P0CV95 515 2.9e-51 (3S,6E)-nerolidol synthase 2, chloroplastic/mitochondrial OS=Fragaria ananassa PE=1 SV=1 PF01397//PF03936 Terpene synthase, N-terminal domain//Terpene synthase family, metal binding domain GO:0008152 metabolic process GO:0000287//GO:0016829//GO:0010333 magnesium ion binding//lyase activity//terpene synthase activity -- -- -- -- Cluster-8309.16103 BF_2 64.36 0.45 6258 642930587 XP_008198239.1 2456 6.6e-274 PREDICTED: sodium/potassium/calcium exchanger Nckx30C isoform X5 [Tribolium castaneum] 642930584 XM_008200013.1 723 0 PREDICTED: Tribolium castaneum sodium/potassium/calcium exchanger Nckx30C (LOC655611), transcript variant X4, mRNA K13750 SLC24A2, NCKX2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13750 Q9U6A0 2069 2.0e-230 Sodium/potassium/calcium exchanger Nckx30C OS=Drosophila melanogaster GN=Nckx30C PE=2 SV=4 PF00105//PF02038//PF05438//PF01699 Zinc finger, C4 type (two domains)//ATP1G1/PLM/MAT8 family//Thyrotropin-releasing hormone (TRH)//Sodium/calcium exchanger protein GO:0055085//GO:0009755//GO:0007218//GO:0006355//GO:0006811 transmembrane transport//hormone-mediated signaling pathway//neuropeptide signaling pathway//regulation of transcription, DNA-templated//ion transport GO:0005184//GO:0008270//GO:0005216//GO:0043565//GO:0003700 neuropeptide hormone activity//zinc ion binding//ion channel activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005634//GO:0005667//GO:0016020//GO:0005576 integral component of membrane//nucleus//transcription factor complex//membrane//extracellular region KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.16105 BF_2 13.00 0.52 1343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16107 BF_2 1.51 0.55 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16108 BF_2 14.49 2.48 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16109 BF_2 18.85 0.42 2152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04851 Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003677//GO:0016787 ATP binding//DNA binding//hydrolase activity -- -- -- -- Cluster-8309.16111 BF_2 8.00 1.80 473 675370958 KFM63860.1 200 2.0e-13 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q53H47 127 2.4e-06 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16112 BF_2 9.00 0.78 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16115 BF_2 63.99 1.20 2511 642936860 XP_008197931.1 2345 2.0e-261 PREDICTED: sodium- and chloride-dependent glycine transporter 1-like [Tribolium castaneum] -- -- -- -- -- K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 Q9Y345 1102 1.1e-118 Sodium- and chloride-dependent glycine transporter 2 OS=Homo sapiens GN=SLC6A5 PE=1 SV=3 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3660 Sodium-neurotransmitter symporter Cluster-8309.16116 BF_2 111.73 1.97 2659 91078380 XP_974219.1 314 6.7e-26 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P93748 186 1.9e-12 Putative E3 ubiquitin-protein ligase SINAT1 OS=Arabidopsis thaliana GN=SINAT1 PE=3 SV=1 PF03145//PF05353//PF02176 Seven in absentia protein family//Delta Atracotoxin//TRAF-type zinc finger GO:0006511//GO:0006810//GO:0007275//GO:0009405 ubiquitin-dependent protein catabolic process//transport//multicellular organismal development//pathogenesis GO:0019871//GO:0008270 sodium channel inhibitor activity//zinc ion binding GO:0005576//GO:0005634 extracellular region//nucleus -- -- Cluster-8309.16118 BF_2 10.00 0.36 1442 807041545 XP_012161435.1 158 4.5e-08 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like [Ceratitis capitata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16123 BF_2 37.15 0.83 2167 795017626 XP_011858919.1 264 3.4e-20 PREDICTED: uncharacterized protein LOC105556435, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16126 BF_2 49.62 0.67 3407 189238203 XP_001809288.1 993 1.6e-104 PREDICTED: TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y6J9 161 2.0e-09 TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L OS=Homo sapiens GN=TAF6L PE=1 SV=1 PF05482//PF01044//PF02969 Serendipity locus alpha protein (SRY-A)//Vinculin family//TATA box binding protein associated factor (TAF) GO:0006352//GO:0007349//GO:0007155 DNA-templated transcription, initiation//cellularization//cell adhesion GO:0051015 actin filament binding GO:0005737//GO:0016020//GO:0005634 cytoplasm//membrane//nucleus KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.16130 BF_2 23.00 1.70 854 91083837 XP_973761.1 286 3.8e-23 PREDICTED: endocuticle structural glycoprotein ABD-4 [Tribolium castaneum]>gi|270006768|gb|EFA03216.1| hypothetical protein TcasGA2_TC013136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21799 194 7.3e-14 Endocuticle structural glycoprotein ABD-4 OS=Locusta migratoria PE=1 SV=3 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.16133 BF_2 1.00 1.43 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16134 BF_2 22.85 0.32 3259 815765768 XP_012215589.1 168 7.0e-09 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.16137 BF_2 84.27 1.64 2437 815765768 XP_012215589.1 186 4.3e-11 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q9D305 146 7.7e-08 THAP domain-containing protein 2 OS=Mus musculus GN=Thap2 PE=2 SV=1 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16138 BF_2 8.25 0.82 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16139 BF_2 127.97 1.35 4263 642928261 XP_008195511.1 1481 5.1e-161 PREDICTED: leucine-rich repeat-containing protein 49 [Tribolium castaneum] -- -- -- -- -- K16606 LRRC49 leucine-rich repeat-containing protein 49 http://www.genome.jp/dbget-bin/www_bget?ko:K16606 Q91YK0 494 5.9e-48 Leucine-rich repeat-containing protein 49 OS=Mus musculus GN=Lrrc49 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.16144 BF_2 12.00 0.45 1414 260835964 XP_002612977.1 167 4.0e-09 hypothetical protein BRAFLDRAFT_143777 [Branchiostoma floridae]>gi|229298359|gb|EEN68986.1| hypothetical protein BRAFLDRAFT_143777, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16148 BF_2 28.82 0.43 3081 642910461 XP_008190748.1 1890 1.4e-208 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] 462340826 APGK01036266.1 75 2.83395e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1134 2.6e-122 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF06305//PF07714//PF00069 Protein of unknown function (DUF1049)//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.16154 BF_2 549.93 4.72 5163 110431376 NP_001036036.1 2891 0.0e+00 short gastrulation precursor [Tribolium castaneum]>gi|94483096|gb|ABF22614.1| short gastrulation [Tribolium castaneum] -- -- -- -- -- K04657 CHRD chordin http://www.genome.jp/dbget-bin/www_bget?ko:K04657 Q24025 1934 7.6e-215 Dorsal-ventral patterning protein Sog OS=Drosophila melanogaster GN=sog PE=1 SV=1 PF00093//PF15957 von Willebrand factor type C domain//Commissureless GO:0007411 axon guidance GO:0005515 protein binding -- -- -- -- Cluster-8309.16158 BF_2 7.00 1.84 446 546681620 ERL91681.1 252 1.7e-19 hypothetical protein D910_09008 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1616 BF_2 2.00 0.32 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00910 RNA helicase -- -- GO:0003723//GO:0003724 RNA binding//RNA helicase activity -- -- -- -- Cluster-8309.16164 BF_2 23.00 0.52 2136 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16166 BF_2 31.10 0.34 4162 642933323 XP_008197368.1 1156 2.4e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 3.9e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.16168 BF_2 10.43 0.36 1484 282721014 NP_001164207.1 444 3.2e-41 serine protease P76 precursor [Tribolium castaneum]>gi|270006343|gb|EFA02791.1| serine protease P76 [Tribolium castaneum] -- -- -- -- -- K09635 TMPRSS4 transmembrane protease, serine 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09635 P35037 401 1.3e-37 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0003824 serine-type endopeptidase activity//catalytic activity -- -- -- -- Cluster-8309.16170 BF_2 41.73 2.89 892 642916483 XP_966412.2 314 2.3e-26 PREDICTED: pickpocket protein 28-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.16173 BF_2 1.03 0.34 413 270002553 EEZ99000.1 327 3.2e-28 hypothetical protein TcasGA2_TC004861 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9CPV7 154 1.5e-09 Palmitoyltransferase ZDHHC6 OS=Mus musculus GN=Zdhhc6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16174 BF_2 112.39 3.95 1477 91076372 XP_967795.1 1477 5.2e-161 PREDICTED: palmitoyltransferase ZDHHC6 [Tribolium castaneum] 871251020 XM_005104281.2 41 1.06758e-09 PREDICTED: Aplysia californica palmitoyltransferase ZDHHC6-like (LOC101847980), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q2HJ95 841 1.2e-88 Palmitoyltransferase ZDHHC6 OS=Bos taurus GN=ZDHHC6 PE=2 SV=1 PF01363//PF01529 FYVE zinc finger//DHHC palmitoyltransferase -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1314 DHHC-type Zn-finger protein Cluster-8309.16175 BF_2 25.46 0.82 1589 91076372 XP_967795.1 974 1.2e-102 PREDICTED: palmitoyltransferase ZDHHC6 [Tribolium castaneum] 871251020 XM_005104281.2 34 8.95707e-06 PREDICTED: Aplysia californica palmitoyltransferase ZDHHC6-like (LOC101847980), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5REH2 552 4.2e-55 Palmitoyltransferase ZDHHC6 OS=Pongo abelii GN=ZDHHC6 PE=3 SV=1 PF01529//PF00033 DHHC palmitoyltransferase//Cytochrome b/b6/petB GO:0022904 respiratory electron transport chain GO:0008270 zinc ion binding GO:0016020 membrane KOG1314 DHHC-type Zn-finger protein Cluster-8309.16176 BF_2 113.21 5.09 1218 646711129 KDR16428.1 939 1.0e-98 Lipase 3 [Zootermopsis nevadensis] -- -- -- -- -- K14452 LIPF gastric triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14452 O46108 804 1.9e-84 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.16180 BF_2 1.29 0.59 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16182 BF_2 150.65 3.66 2010 478254477 ENN74726.1 1349 4.9e-146 hypothetical protein YQE_08693, partial [Dendroctonus ponderosae]>gi|546685047|gb|ERL94601.1| hypothetical protein D910_11878 [Dendroctonus ponderosae] -- -- -- -- -- K13205 AAR2, C20orf4 A1 cistron-splicing factor AAR2 http://www.genome.jp/dbget-bin/www_bget?ko:K13205 Q08DJ7 779 2.5e-81 Protein AAR2 homolog OS=Bos taurus GN=AAR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3937 mRNA splicing factor Cluster-8309.16183 BF_2 35.59 1.03 1733 478250692 ENN71184.1 1414 1.2e-153 hypothetical protein YQE_12114, partial [Dendroctonus ponderosae]>gi|546678623|gb|ERL89205.1| hypothetical protein D910_06579 [Dendroctonus ponderosae] -- -- -- -- -- K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 464 7.3e-45 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00098//PF00852 Zinc knuckle//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008270//GO:0008417//GO:0003676 zinc ion binding//fucosyltransferase activity//nucleic acid binding GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.16186 BF_2 4.00 0.37 739 733930734 XP_010726056.1 212 1.2e-14 PREDICTED: protein pygopus-like, partial [Meleagris gallopavo] -- -- -- -- -- -- -- -- -- Q5UNY5 125 6.3e-06 Uncharacterized protein R727 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_R727 PE=1 SV=1 PF15324 Hedgehog signalling target GO:0007224 smoothened signaling pathway -- -- -- -- -- -- Cluster-8309.16188 BF_2 195.35 1.10 7740 859132808 AKO63318.1 2842 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2206 3.3e-246 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF13639//PF00368//PF02460//PF00283//PF17123//PF00643//PF00628//PF14634 Ring finger domain//Hydroxymethylglutaryl-coenzyme A reductase//Patched family//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//RING-like zinc finger//B-box zinc finger//PHD-finger//zinc-RING finger domain GO:0015936//GO:0006694//GO:0055114//GO:0015979//GO:0007165 coenzyme A metabolic process//steroid biosynthetic process//oxidation-reduction process//photosynthesis//signal transduction GO:0004420//GO:0008270//GO:0008158//GO:0050662//GO:0005515 hydroxymethylglutaryl-CoA reductase (NADPH) activity//zinc ion binding//hedgehog receptor activity//coenzyme binding//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.16190 BF_2 198.38 1.10 7814 859132808 AKO63318.1 2842 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2206 3.3e-246 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF17123//PF00283//PF00643//PF00628//PF14634//PF02460//PF00368//PF13639 RING-like zinc finger//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//B-box zinc finger//PHD-finger//zinc-RING finger domain//Patched family//Hydroxymethylglutaryl-coenzyme A reductase//Ring finger domain GO:0015936//GO:0006694//GO:0055114//GO:0015979//GO:0007165 coenzyme A metabolic process//steroid biosynthetic process//oxidation-reduction process//photosynthesis//signal transduction GO:0004420//GO:0008270//GO:0050662//GO:0008158//GO:0005515 hydroxymethylglutaryl-CoA reductase (NADPH) activity//zinc ion binding//coenzyme binding//hedgehog receptor activity//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.16193 BF_2 55.22 2.31 1287 546674232 ERL85660.1 170 1.6e-09 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00737 Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0042301 phosphate ion binding GO:0016020//GO:0009523 membrane//photosystem II -- -- Cluster-8309.16194 BF_2 105.00 2.82 1845 571330962 AHF27413.1 1578 1.3e-172 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A9ZSY3 473 7.0e-46 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.16197 BF_2 110.96 1.35 3730 91079028 XP_974924.1 1752 1.7e-192 PREDICTED: glutamate-rich WD repeat-containing protein 1 [Tribolium castaneum]>gi|270004178|gb|EFA00626.1| hypothetical protein TcasGA2_TC003502 [Tribolium castaneum] 687865299 LK927543.1 35 5.91805e-06 Caenorhabditis elegans genome assembly C_elegans_Bristol_N2_v1_5_4 ,scaffold CELN2_scaffold0000013 K14848 RRB1, GRWD1 ribosome assembly protein RRB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14848 Q9BQ67 1160 3.1e-125 Glutamate-rich WD repeat-containing protein 1 OS=Homo sapiens GN=GRWD1 PE=1 SV=1 PF00400//PF01119//PF08676 WD domain, G-beta repeat//DNA mismatch repair protein, C-terminal domain//MutL C terminal dimerisation domain GO:0006298 mismatch repair GO:0005524//GO:0030983//GO:0005515 ATP binding//mismatched DNA binding//protein binding GO:0005634 nucleus KOG0302 Ribosome Assembly protein Cluster-8309.16199 BF_2 22.00 1.04 1171 332183937 AEE26197.1 1517 9.4e-166 farnesoic acid O-methyltransferase short isoform [Scylla paramamosain] 396582128 HQ587050.2 1153 0 Scylla paramamosain farnesoic acid O-methyltransferase short isoform mRNA, complete cds -- -- -- -- Q8IZJ3 204 6.9e-15 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens GN=CPAMD8 PE=1 SV=2 PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.16204 BF_2 4.00 1.47 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16205 BF_2 73.14 4.93 908 642939494 XP_008190865.1 902 1.5e-94 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 Q7G193 418 8.2e-40 Indole-3-acetaldehyde oxidase OS=Arabidopsis thaliana GN=AAO1 PE=1 SV=2 PF00941//PF01799//PF00111 FAD binding domain in molybdopterin dehydrogenase//[2Fe-2S] binding domain//2Fe-2S iron-sulfur cluster binding domain GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0051536//GO:0046872//GO:0016491 electron carrier activity//iron-sulfur cluster binding//metal ion binding//oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.16207 BF_2 551.76 11.16 2356 478256643 ENN76825.1 678 3.7e-68 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAM1 447 9.3e-43 Alpha-taxilin OS=Mus musculus GN=Txlna PE=2 SV=1 PF13851//PF01418//PF05336//PF09728 Growth-arrest specific micro-tubule binding//Helix-turn-helix domain, rpiR family//Domain of unknown function (DUF718)//Myosin-like coiled-coil protein GO:0006355//GO:0019299//GO:0048870 regulation of transcription, DNA-templated//rhamnose metabolic process//cell motility GO:0003700//GO:0016857//GO:0019905 transcription factor activity, sequence-specific DNA binding//racemase and epimerase activity, acting on carbohydrates and derivatives//syntaxin binding GO:0005737//GO:0031514//GO:0005667 cytoplasm//motile cilium//transcription factor complex KOG1850 Myosin-like coiled-coil protein Cluster-8309.16208 BF_2 30.49 0.54 2647 642938308 XP_008192812.1 208 1.3e-13 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X4 [Tribolium castaneum] 642938318 XM_008194620.1 57 2.46637e-18 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X11, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- PF02173 pKID domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-8309.16209 BF_2 57.28 0.32 7872 642932112 XP_008196860.1 3146 0.0e+00 PREDICTED: ABC transporter G family member 14 isoform X1 [Tribolium castaneum] 642932111 XM_008198638.1 779 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA -- -- -- -- Q6WV17 1239 4.5e-134 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF13304//PF01926//PF01061//PF00437//PF00004//PF01637//PF03193//PF00005//PF05418//PF10662//PF00910 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//Apovitellenin I (Apo-VLDL-II)//Ethanolamine utilisation - propanediol utilisation//RNA helicase GO:0006810//GO:0006629//GO:0006576 transport//lipid metabolic process//cellular biogenic amine metabolic process GO:0003724//GO:0016887//GO:0005525//GO:0003924//GO:0004857//GO:0005524//GO:0003723 RNA helicase activity//ATPase activity//GTP binding//GTPase activity//enzyme inhibitor activity//ATP binding//RNA binding GO:0042627//GO:0016020 chylomicron//membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.16211 BF_2 8.00 1.76 477 795149790 XP_011838280.1 371 2.9e-33 PREDICTED: RAC-alpha serine/threonine-protein kinase-like [Mandrillus leucophaeus] 440502988 JX512440.1 477 0 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1) gene, complete cds K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q98TY9 298 3.5e-26 RAC-alpha serine/threonine-protein kinase OS=Xenopus laevis GN=akt1 PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.16213 BF_2 5.00 0.56 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16215 BF_2 131.00 3.72 1760 478263263 ENN81647.1 2130 1.2e-236 hypothetical protein YQE_01945, partial [Dendroctonus ponderosae] 805819936 XM_003707231.2 208 1.86826e-102 PREDICTED: Megachile rotundata peptidyl-prolyl cis-trans isomerase-like 2 (LOC100880954), mRNA K10598 PPIL2, CYC4, CHP60 peptidyl-prolyl cis-trans isomerase-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10598 Q9D787 1489 1.0e-163 Peptidyl-prolyl cis-trans isomerase-like 2 OS=Mus musculus GN=Ppil2 PE=1 SV=2 PF11789//PF00160 Zinc-finger of the MIZ type in Nse subunit//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0008270//GO:0003755 zinc ion binding//peptidyl-prolyl cis-trans isomerase activity -- -- KOG0883 Cyclophilin type, U box-containing peptidyl-prolyl cis-trans isomerase Cluster-8309.16216 BF_2 24.61 1.38 1032 570341948 AHE77372.1 494 3.5e-47 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 285 2.5e-24 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.16218 BF_2 7.41 0.83 660 642912272 XP_008200632.1 233 4.1e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16221 BF_2 63.91 0.40 6950 642921743 XP_008199309.1 1367 1.4e-147 PREDICTED: protein kinase C-binding protein 1 isoform X2 [Tribolium castaneum] 688610729 XM_009296665.1 57 6.52348e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 819 2.0e-85 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF00439//PF03832//PF00628 Bromodomain//WSK motif//PHD-finger GO:0006605//GO:0007165 protein targeting//signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.16223 BF_2 178.80 1.12 6966 642921743 XP_008199309.1 1367 1.4e-147 PREDICTED: protein kinase C-binding protein 1 isoform X2 [Tribolium castaneum] 688610729 XM_009296665.1 57 6.53858e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 819 2.0e-85 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF00439//PF00628//PF03832 Bromodomain//PHD-finger//WSK motif GO:0006605//GO:0007165 protein targeting//signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.16225 BF_2 112.16 0.82 6000 478257235 ENN77398.1 1108 1.3e-117 hypothetical protein YQE_06223, partial [Dendroctonus ponderosae] 688610729 XM_009296665.1 57 5.62972e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 643 4.4e-65 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF03832//PF00439 WSK motif//Bromodomain GO:0006605//GO:0007165 protein targeting//signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.16226 BF_2 105.00 17.37 540 584482886 AHJ09940.1 538 1.4e-52 glycoside hydrolase family 28 [Apriona japonica] 584482885 KF724642.1 308 1.41007e-158 Apriona japonica glycoside hydrolase family 28 (gh28-2) mRNA, complete cds -- -- -- -- O93883 274 2.4e-23 Polygalacturonase OS=Penicillium griseoroseum GN=PGG1 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.16227 BF_2 26.00 1.08 1297 795264447 XP_011811659.1 1705 1.7e-187 PREDICTED: glyceraldehyde-3-phosphate dehydrogenase-like isoform X1 [Colobus angolensis palliatus] 9802301 AF261085.1 1254 0 AF261085 Homo sapiens glyceraldehyde-3-phosphate dehydrogenase (GADPH) mRNA, complete cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q5RAB4 1719 1.6e-190 Glyceraldehyde-3-phosphate dehydrogenase OS=Pongo abelii GN=GAPDH PE=2 SV=3 PF00044//PF01113//PF02800 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Dihydrodipicolinate reductase, N-terminus//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0009085//GO:0055114//GO:0009089 lysine biosynthetic process//oxidation-reduction process//lysine biosynthetic process via diaminopimelate GO:0016620//GO:0008839 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//4-hydroxy-tetrahydrodipicolinate reductase -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.16229 BF_2 52.56 1.40 1853 820805536 AKG92759.1 682 1.0e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.83219e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 4.9e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF00010//PF01586 Helix-loop-helix DNA-binding domain//Myogenic Basic domain GO:0007517//GO:0006355 muscle organ development//regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.16230 BF_2 334.04 3.02 4916 91077028 XP_967318.1 1305 1.5e-140 PREDICTED: moesin/ezrin/radixin homolog 1 [Tribolium castaneum]>gi|270002017|gb|EEZ98464.1| hypothetical protein TcasGA2_TC000955 [Tribolium castaneum] -- -- -- -- -- K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 988 3.6e-105 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF00769//PF00551//PF02911//PF05531//PF00887 Ezrin/radixin/moesin family//Formyl transferase//Formyl transferase, C-terminal domain//Nucleopolyhedrovirus P10 protein//Acyl CoA binding protein GO:0009058 biosynthetic process GO:0000062//GO:0008092//GO:0016742 fatty-acyl-CoA binding//cytoskeletal protein binding//hydroxymethyl-, formyl- and related transferase activity GO:0019898//GO:0019028//GO:0005737 extrinsic component of membrane//viral capsid//cytoplasm KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.16231 BF_2 216.00 7.38 1511 189240241 XP_001810647.1 1034 1.2e-109 PREDICTED: carboxypeptidase B [Tribolium castaneum]>gi|270012801|gb|EFA09249.1| carboxypeptidase A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04069 682 3.3e-70 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF02244//PF07224//PF00246 Carboxypeptidase activation peptide//Chlorophyllase//Zinc carboxypeptidase GO:0015994//GO:0015996//GO:0006508 chlorophyll metabolic process//chlorophyll catabolic process//proteolysis GO:0047746//GO:0004180//GO:0004181//GO:0008270 chlorophyllase activity//carboxypeptidase activity//metallocarboxypeptidase activity//zinc ion binding -- -- KOG2650 Zinc carboxypeptidase Cluster-8309.16232 BF_2 33.10 7.06 483 642923877 XP_008193910.1 513 1.0e-49 PREDICTED: aristaless isoform X1 [Tribolium castaneum] 543718138 XM_005500258.1 59 3.28683e-20 PREDICTED: Columba livia ALX homeobox 4 (ALX4), mRNA K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 Q06453 405 1.4e-38 Homeobox protein aristaless OS=Drosophila melanogaster GN=al PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.16239 BF_2 14.52 0.92 948 795014455 XP_011883890.1 227 2.9e-16 PREDICTED: uncharacterized protein LOC105571033 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16243 BF_2 2.00 0.40 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16245 BF_2 44.00 3.02 896 873237682 CEL97078.1 269 3.7e-21 unnamed protein product [Vitrella brassicaformis CCMP3155] 119395219 EF122484.1 845 0 Oryza sativa (japonica cultivar-group) clone KCS334B01 germin-like protein mRNA, complete cds -- -- -- -- Q6YZA9 1050 4.2e-113 Germin-like protein 8-2 OS=Oryza sativa subsp. japonica GN=GER3 PE=2 SV=1 PF00190 Cupin -- -- GO:0045735 nutrient reservoir activity -- -- -- -- Cluster-8309.16248 BF_2 76.00 5.06 915 642929783 XP_008195974.1 313 3.0e-26 PREDICTED: antifreeze protein Maxi-like [Tribolium castaneum]>gi|642929785|ref|XP_008195975.1| PREDICTED: antifreeze protein Maxi-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02970//PF04111//PF03153//PF13851//PF04614 Tubulin binding cofactor A//Autophagy protein Apg6//Transcription factor IIA, alpha/beta subunit//Growth-arrest specific micro-tubule binding//Pex19 protein family GO:0006914//GO:0048870//GO:0006367//GO:0007021 autophagy//cell motility//transcription initiation from RNA polymerase II promoter//tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0005777//GO:0045298//GO:0031514//GO:0005672 peroxisome//tubulin complex//motile cilium//transcription factor TFIIA complex -- -- Cluster-8309.16257 BF_2 9.00 0.68 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16258 BF_2 223.18 3.46 2984 91094373 XP_970761.1 1832 7.2e-202 PREDICTED: COP9 signalosome complex subunit 3 [Tribolium castaneum]>gi|270014914|gb|EFA11362.1| hypothetical protein TcasGA2_TC011519 [Tribolium castaneum] -- -- -- -- -- K12177 COPS3, CSN3 COP9 signalosome complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12177 Q6P2U9 1279 3.9e-139 COP9 signalosome complex subunit 3 OS=Danio rerio GN=cops3 PE=2 SV=1 PF03791//PF01399 KNOX2 domain//PCI domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG2582 COP9 signalosome, subunit CSN3 Cluster-8309.16259 BF_2 11.95 0.32 1843 91082039 XP_970789.1 1573 4.8e-172 PREDICTED: integrator complex subunit 4 [Tribolium castaneum]>gi|270007301|gb|EFA03749.1| hypothetical protein TcasGA2_TC013858 [Tribolium castaneum] -- -- -- -- -- K13141 INTS4 integrator complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13141 Q8CIM8 798 1.4e-83 Integrator complex subunit 4 OS=Mus musculus GN=Ints4 PE=1 SV=1 PF02985//PF01602//PF11991 HEAT repeat//Adaptin N terminal region//Tryptophan dimethylallyltransferase GO:0016192//GO:0006886//GO:0009820 vesicle-mediated transport//intracellular protein transport//alkaloid metabolic process GO:0005515//GO:0050364 protein binding//tryptophan dimethylallyltransferase activity GO:0030117 membrane coat -- -- Cluster-8309.16261 BF_2 15.19 0.32 2298 91082039 XP_970789.1 2432 1.5e-271 PREDICTED: integrator complex subunit 4 [Tribolium castaneum]>gi|270007301|gb|EFA03749.1| hypothetical protein TcasGA2_TC013858 [Tribolium castaneum] 751460794 XM_011186873.1 35 3.62663e-06 PREDICTED: Bactrocera cucurbitae integrator complex subunit 4 (LOC105213804), mRNA K13141 INTS4 integrator complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13141 Q96HW7 902 1.6e-95 Integrator complex subunit 4 OS=Homo sapiens GN=INTS4 PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG2259 Uncharacterized conserved protein Cluster-8309.16263 BF_2 277.14 3.59 3518 91082039 XP_970789.1 4010 0.0e+00 PREDICTED: integrator complex subunit 4 [Tribolium castaneum]>gi|270007301|gb|EFA03749.1| hypothetical protein TcasGA2_TC013858 [Tribolium castaneum] 751460794 XM_011186873.1 38 1.199e-07 PREDICTED: Bactrocera cucurbitae integrator complex subunit 4 (LOC105213804), mRNA K13141 INTS4 integrator complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13141 Q8CIM8 1700 7.0e-188 Integrator complex subunit 4 OS=Mus musculus GN=Ints4 PE=1 SV=1 PF01602//PF11991//PF02985 Adaptin N terminal region//Tryptophan dimethylallyltransferase//HEAT repeat GO:0009820//GO:0006886//GO:0016192 alkaloid metabolic process//intracellular protein transport//vesicle-mediated transport GO:0050364//GO:0005515 tryptophan dimethylallyltransferase activity//protein binding GO:0030117 membrane coat KOG2259 Uncharacterized conserved protein Cluster-8309.16264 BF_2 2.00 0.42 485 748995284 AJE75664.1 513 1.0e-49 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 282 2.6e-24 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.16265 BF_2 29.52 0.87 1706 748995284 AJE75664.1 1559 1.9e-170 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 922 5.6e-98 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.16266 BF_2 15.00 2.16 578 546672528 ERL84351.1 292 5.2e-24 hypothetical protein D910_01776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16268 BF_2 16.00 6.72 385 21667216 AAM73986.1 573 9.0e-57 alpha-tubulin 1 [Homarus gammarus] 2098752 U92646.1 286 1.66534e-146 GLU92646 Gecarcinus lateralis alpha-2-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q3ZCJ7 561 9.1e-57 Tubulin alpha-1C chain OS=Bos taurus GN=TUBA1C PE=1 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.16272 BF_2 331.51 35.85 674 748995296 AJE75670.1 780 1.6e-80 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q38786 528 1.1e-52 Avenacosidase 1 OS=Avena sativa GN=P60A PE=1 SV=1 PF00150//PF00232 Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.16276 BF_2 68.59 1.08 2955 642924825 XP_967668.2 841 5.8e-87 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 496 2.4e-48 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16278 BF_2 17.72 0.59 1553 332375989 AEE63135.1 933 6.5e-98 unknown [Dendroctonus ponderosae]>gi|478258650|gb|ENN78700.1| hypothetical protein YQE_04872, partial [Dendroctonus ponderosae] 645003560 XR_512750.1 69 3.0591e-25 PREDICTED: Nasonia vitripennis kidney mitochondrial carrier protein 1 (LOC100120159), transcript variant X2, misc_RNA K15106 SLC25A14_30 solute carrier family 25 (mitochondrial carrier), member 14/30 http://www.genome.jp/dbget-bin/www_bget?ko:K15106 O95258 596 3.2e-60 Brain mitochondrial carrier protein 1 OS=Homo sapiens GN=SLC25A14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.16282 BF_2 28.00 1.51 1063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16283 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16285 BF_2 72.37 0.76 4285 642919915 XP_008192123.1 1839 1.6e-202 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9K8 222 2.1e-16 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0507 CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain Cluster-8309.16286 BF_2 8.00 5.03 349 190700 AAA36524.1 290 5.3e-24 papillary thyroid carcinoma-encoded protein [Homo sapiens] 336042955 JF276429.1 349 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 290 2.2e-25 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16289 BF_2 70.82 2.99 1277 270012424 EFA08872.1 327 1.0e-27 hypothetical protein TcasGA2_TC006573 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.16294 BF_2 41.03 0.76 2546 827542484 XP_012544315.1 618 3.6e-61 PREDICTED: uncharacterized protein LOC105841373 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00218 Indole-3-glycerol phosphate synthase GO:0000162//GO:0006571//GO:0009094 tryptophan biosynthetic process//tyrosine biosynthetic process//L-phenylalanine biosynthetic process GO:0004425 indole-3-glycerol-phosphate synthase activity -- -- -- -- Cluster-8309.16295 BF_2 110.97 2.09 2513 827542484 XP_012544315.1 474 1.8e-44 PREDICTED: uncharacterized protein LOC105841373 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11093 Mitochondrial export protein Som1 -- -- -- -- GO:0042720 mitochondrial inner membrane peptidase complex -- -- Cluster-8309.16297 BF_2 253.82 3.08 3731 478251121 ENN71597.1 2722 5.6e-305 hypothetical protein YQE_11696, partial [Dendroctonus ponderosae] 543338846 XM_005516267.1 47 1.26338e-12 PREDICTED: Pseudopodoces humilis mitochondrial intermediate peptidase (MIPEP), mRNA K01410 MIPEP mitochondrial intermediate peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01410 Q99797 1823 4.1e-202 Mitochondrial intermediate peptidase OS=Homo sapiens GN=MIPEP PE=1 SV=2 PF01432//PF08533 Peptidase family M3//Beta-galactosidase C-terminal domain GO:0006687//GO:0046486//GO:0006508//GO:0006027//GO:0006012 glycosphingolipid metabolic process//glycerolipid metabolic process//proteolysis//glycosaminoglycan catabolic process//galactose metabolic process GO:0004222//GO:0004565 metalloendopeptidase activity//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG2090 Metalloendopeptidase family - mitochondrial intermediate peptidase Cluster-8309.16299 BF_2 133.50 3.69 1800 270012020 EFA08468.1 340 4.4e-29 hypothetical protein TcasGA2_TC006118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32P12 206 6.2e-15 Uncharacterized protein C17orf53 homolog OS=Mus musculus PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16301 BF_2 2.00 0.48 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16305 BF_2 67.00 1.99 1698 91094009 XP_971372.1 981 1.9e-103 PREDICTED: probable palmitoyltransferase ZDHHC24 [Tribolium castaneum]>gi|270016169|gb|EFA12617.1| hypothetical protein TcasGA2_TC006858 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q6IR37 324 1.2e-28 Probable palmitoyltransferase ZDHHC24 OS=Mus musculus GN=Zdhhc24 PE=2 SV=2 PF01529//PF06703 DHHC palmitoyltransferase//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008270//GO:0008233//GO:0046872 zinc ion binding//peptidase activity//metal ion binding GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG1311 DHHC-type Zn-finger proteins Cluster-8309.16306 BF_2 83.72 0.87 4307 91086991 XP_973570.1 1347 1.8e-145 PREDICTED: maspardin [Tribolium castaneum]>gi|270010508|gb|EFA06956.1| hypothetical protein TcasGA2_TC009913 [Tribolium castaneum] -- -- -- -- -- K19367 SPG21 maspardin http://www.genome.jp/dbget-bin/www_bget?ko:K19367 Q6PC62 932 9.8e-99 Maspardin OS=Danio rerio GN=spg21 PE=2 SV=1 PF13145//PF14736 PPIC-type PPIASE domain//Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418//GO:0016853 protein-N-terminal asparagine amidohydrolase activity//isomerase activity -- -- -- -- Cluster-8309.16308 BF_2 301.90 2.19 6065 91086723 XP_970869.1 1356 2.3e-146 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 1.60488e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 757 2.7e-78 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535//PF05637 ZIP Zinc transporter//galactosyl transferase GMA12/MNN10 family GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0016757//GO:0046873 transferase activity, transferring glycosyl groups//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2693 Putative zinc transporter Cluster-8309.16310 BF_2 12.00 1.08 752 871220071 XP_012935677.1 723 7.1e-74 PREDICTED: ADP-ribosylation factor 1-like [Aplysia californica] 694411469 XM_009335822.1 323 9.17828e-167 PREDICTED: Pyrus x bretschneideri ADP-ribosylation factor 1 (LOC103926940), transcript variant X2, mRNA K07938 ARF3 ADP-ribosylation factor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07938 P36397 793 2.2e-83 ADP-ribosylation factor 1 OS=Arabidopsis thaliana GN=ARF1 PE=1 SV=2 PF01926//PF08477//PF04670//PF00025//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//G-protein alpha subunit GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTP binding -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.16313 BF_2 176.92 3.03 2726 642918316 XP_008191456.1 959 1.1e-100 PREDICTED: proline-, glutamic acid- and leucine-rich protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZL8 169 1.8e-10 Proline-, glutamic acid- and leucine-rich protein 1 OS=Homo sapiens GN=PELP1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16316 BF_2 96.59 2.28 2061 91087945 XP_972135.1 1136 2.5e-121 PREDICTED: CUE domain-containing protein 2 [Tribolium castaneum]>gi|270011934|gb|EFA08382.1| hypothetical protein TcasGA2_TC006025 [Tribolium castaneum] 642930958 XM_967042.2 295 9.51161e-151 PREDICTED: Tribolium castaneum CUE domain-containing protein 2 (LOC660839), mRNA -- -- -- -- Q6TLH3 407 3.5e-38 CUE domain-containing protein 2 OS=Danio rerio GN=cuedc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.16317 BF_2 55.00 1.94 1471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16321 BF_2 39.03 0.58 3108 270010378 EFA06826.1 2294 2.0e-255 hypothetical protein TcasGA2_TC009768 [Tribolium castaneum] 642928761 XM_008201551.1 820 0 PREDICTED: Tribolium castaneum nephrin (LOC663236), mRNA -- -- -- -- Q9R044 217 5.7e-16 Nephrin OS=Rattus norvegicus GN=Nphs1 PE=1 SV=2 PF00041//PF04850//PF13895 Fibronectin type III domain//Baculovirus E66 occlusion-derived virus envelope protein//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0019031 viral envelope -- -- Cluster-8309.16322 BF_2 245.46 14.38 1001 91080431 XP_968599.1 343 1.1e-29 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16323 BF_2 3.00 0.42 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16324 BF_2 14.36 0.61 1273 91080431 XP_968599.1 343 1.4e-29 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16325 BF_2 4.00 0.36 757 91077322 XP_974743.1 423 4.4e-39 PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|642913792|ref|XP_008201162.1| PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|270002090|gb|EEZ98537.1| hypothetical protein TcasGA2_TC001041 [Tribolium castaneum] 632985180 XM_007911344.1 101 2.3708e-43 PREDICTED: Callorhinchus milii pre-mRNA processing factor 18 (prpf18), mRNA K12817 PRPF18, PRP18 pre-mRNA-splicing factor 18 http://www.genome.jp/dbget-bin/www_bget?ko:K12817 Q9JKB8 368 4.3e-34 Pre-mRNA-splicing factor 18 OS=Rattus norvegicus GN=Prpf18 PE=2 SV=1 PF02840 Prp18 domain GO:0008380 RNA splicing -- -- GO:0005681 spliceosomal complex KOG2808 U5 snRNP-associated RNA splicing factor Cluster-8309.16326 BF_2 25.00 0.55 2190 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16328 BF_2 7.63 0.35 1207 642919571 XP_008191927.1 497 1.8e-47 PREDICTED: protein angel isoform X2 [Tribolium castaneum] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 234 2.4e-18 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2338 Transcriptional effector CCR4-related protein Cluster-8309.16333 BF_2 5.47 0.46 780 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16336 BF_2 5.00 0.49 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16337 BF_2 5.35 0.40 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16338 BF_2 10.00 0.32 1614 642920550 XP_008192401.1 367 2.9e-32 PREDICTED: uncharacterized protein LOC103312744 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16339 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16342 BF_2 7.00 1.05 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16345 BF_2 15.02 0.73 1148 546683414 ERL93230.1 345 7.4e-30 hypothetical protein D910_10526 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 302 2.9e-26 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16347 BF_2 190.72 1.65 5113 642938541 XP_008199834.1 1798 1.1e-197 PREDICTED: transcription factor Ken isoform X1 [Tribolium castaneum]>gi|270015579|gb|EFA12027.1| hypothetical protein TcasGA2_TC001442 [Tribolium castaneum] 642938542 XM_008201613.1 75 4.72511e-28 PREDICTED: Tribolium castaneum transcription factor Ken (LOC656389), transcript variant X2, mRNA -- -- -- -- Q292R5 588 9.0e-59 Transcription factor Ken OS=Drosophila pseudoobscura pseudoobscura GN=ken PE=3 SV=2 PF13465//PF00096//PF00651//PF00081//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//BTB/POZ domain//Iron/manganese superoxide dismutases, alpha-hairpin domain//C2H2-type zinc finger GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0003676//GO:0008270//GO:0046872//GO:0004784//GO:0005515 nucleic acid binding//zinc ion binding//metal ion binding//superoxide dismutase activity//protein binding GO:0005634 nucleus -- -- Cluster-8309.16348 BF_2 103.74 1.10 4225 642938541 XP_008199834.1 2342 7.4e-261 PREDICTED: transcription factor Ken isoform X1 [Tribolium castaneum]>gi|270015579|gb|EFA12027.1| hypothetical protein TcasGA2_TC001442 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q292R5 588 7.4e-59 Transcription factor Ken OS=Drosophila pseudoobscura pseudoobscura GN=ken PE=3 SV=2 PF00096//PF13465//PF04931//PF00651//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//DNA polymerase phi//BTB/POZ domain//C2H2-type zinc finger GO:0006351//GO:0006260 transcription, DNA-templated//DNA replication GO:0003677//GO:0005515//GO:0003887//GO:0003676//GO:0008270//GO:0046872 DNA binding//protein binding//DNA-directed DNA polymerase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634//GO:0042575 nucleus//DNA polymerase complex -- -- Cluster-8309.16349 BF_2 146.89 5.81 1345 91087239 XP_975511.1 728 3.3e-74 PREDICTED: eukaryotic initiation factor 4A-III [Tribolium castaneum]>gi|270010579|gb|EFA07027.1| hypothetical protein TcasGA2_TC009998 [Tribolium castaneum] 642929692 XM_970418.2 181 1.44923e-87 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4A-III (LOC664411), mRNA K13025 EIF4A3, FAL1 ATP-dependent RNA helicase http://www.genome.jp/dbget-bin/www_bget?ko:K13025 Q9VHS8 679 6.6e-70 Eukaryotic initiation factor 4A-III OS=Drosophila melanogaster GN=eIF4AIII PE=1 SV=1 PF04851//PF00580//PF00270 Type III restriction enzyme, res subunit//UvrD/REP helicase N-terminal domain//DEAD/DEAH box helicase -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524//GO:0008026 hydrolase activity//DNA binding//nucleic acid binding//ATP binding//ATP-dependent helicase activity -- -- KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.16352 BF_2 145.63 3.88 1856 270004106 EFA00554.1 897 1.2e-93 hypothetical protein TcasGA2_TC003421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R5F9 230 1.1e-17 ATP synthase subunit s-like protein OS=Macaca fascicularis GN=ATP5SL PE=2 SV=1 PF00560 Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG3864 Uncharacterized conserved protein Cluster-8309.16360 BF_2 291.88 4.51 2996 189240717 XP_974290.2 956 2.7e-100 PREDICTED: polycomb group protein Pc isoform X3 [Tribolium castaneum]>gi|270014283|gb|EFA10731.1| polycomb [Tribolium castaneum] -- -- -- -- -- K11453 CBX6 chromobox protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11453 P26017 292 1.1e-24 Polycomb group protein Pc OS=Drosophila melanogaster GN=Pc PE=1 SV=1 PF00437 Type II/IV secretion system protein GO:0006810 transport GO:0005524 ATP binding -- -- KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.16364 BF_2 6.00 10.45 291 -- -- -- -- -- 156764690 AK288075.1 258 4.48429e-131 Oryza sativa Japonica Group cDNA, clone: J075162H16, full insert sequence -- -- -- -- P17048 149 4.1e-09 13 kDa prolamin C OS=Oryza sativa subsp. japonica GN=PROLM25 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16369 BF_2 7.00 0.46 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16376 BF_2 210.00 2.09 4498 780175874 XP_011661330.1 807 7.7e-83 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 657 7.9e-67 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05396 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.16380 BF_2 5.16 0.40 829 642916794 XP_008199506.1 589 2.7e-58 PREDICTED: transmembrane protein 70 homolog, mitochondrial [Tribolium castaneum]>gi|270003058|gb|EEZ99505.1| hypothetical protein TcasGA2_TC000082 [Tribolium castaneum] -- -- -- -- -- K17966 TMEM70 transmembrane protein 70, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17966 Q95SS8 390 1.3e-36 Transmembrane protein 70 homolog, mitochondrial OS=Drosophila melanogaster GN=CG7506 PE=2 SV=1 PF03977 Na+-transporting oxaloacetate decarboxylase beta subunit GO:0006814 sodium ion transport GO:0016829 lyase activity -- -- -- -- Cluster-8309.16384 BF_2 52.50 1.41 1849 546684929 ERL94511.1 220 3.7e-15 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.16388 BF_2 18.00 0.65 1450 751233858 XP_011170631.1 441 6.9e-41 PREDICTED: uncharacterized protein LOC105203526 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16389 BF_2 209.73 3.07 3148 91084489 XP_971806.1 713 4.3e-72 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.16393 BF_2 49.73 2.91 1003 573890433 XP_006632978.1 296 3.1e-24 PREDICTED: tyrosine-protein kinase BTK-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- P27446 274 4.5e-23 Tyrosine-protein kinase Fyn OS=Xiphophorus helleri GN=fyn PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.16395 BF_2 10.00 1.27 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16399 BF_2 75.30 0.96 3552 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.7e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16403 BF_2 36.00 0.34 4717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16405 BF_2 706.21 5.63 5531 642918480 XP_008191494.1 5359 0.0e+00 PREDICTED: epidermal growth factor receptor isoform X2 [Tribolium castaneum] -- -- -- -- -- K04361 EGFR, ERBB1 epidermal growth factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04361 P0CY46 4398 0.0e+00 Epidermal growth factor receptor OS=Apis mellifera GN=Egfr PE=2 SV=1 PF00757//PF00069//PF06293//PF07714 Furin-like cysteine rich region//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0016773//GO:0004714//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein tyrosine kinase activity//protein kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.16411 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16415 BF_2 25.06 0.38 3018 795017716 XP_011858948.1 1092 4.7e-116 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105556466 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16416 BF_2 19.79 2.35 640 642937130 XP_008198705.1 178 9.5e-11 PREDICTED: short neuropeptide F-like [Tribolium castaneum]>gi|270001316|gb|EEZ97763.1| short neuropeptide F [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1642 BF_2 8.00 0.35 1244 -- -- -- -- -- 697073026 XM_009652962.1 1238 0 Verticillium dahliae VdLs.17 hypothetical protein mRNA -- -- -- -- Q01302 129 3.7e-06 Clock-controlled protein 6 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=ccg-6 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16423 BF_2 23.09 0.46 2368 91081127 XP_976484.1 739 3.1e-75 PREDICTED: protein maelstrom [Tribolium castaneum]>gi|270006444|gb|EFA02892.1| maelstrom [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0W2W6 461 2.2e-44 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.16426 BF_2 112.88 4.53 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16427 BF_2 2.00 3.18 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16429 BF_2 52.14 0.50 4691 642934488 XP_008197685.1 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934490|ref|XP_008197686.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934492|ref|XP_008197687.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|270013516|gb|EFA09964.1| hypothetical protein TcasGA2_TC012121 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54316 599 4.4e-60 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 -- -- -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.16433 BF_2 2.00 0.43 483 646716488 KDR19726.1 162 5.2e-09 Ferrochelatase, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O57478 146 1.5e-08 Ferrochelatase, mitochondrial OS=Xenopus laevis GN=fech PE=1 SV=1 PF03552//PF00762 Cellulose synthase//Ferrochelatase GO:0015994//GO:0006011//GO:0005985//GO:0030244//GO:0005982//GO:0006783 chlorophyll metabolic process//UDP-glucose metabolic process//sucrose metabolic process//cellulose biosynthetic process//starch metabolic process//heme biosynthetic process GO:0004325//GO:0016760 ferrochelatase activity//cellulose synthase (UDP-forming) activity GO:0016020 membrane KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.16435 BF_2 23.96 1.43 986 91079786 XP_967971.1 1104 6.2e-118 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 857 1.1e-90 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 -- -- GO:0042254//GO:0006396 ribosome biogenesis//RNA processing GO:0003824 catalytic activity GO:0005730 nucleolus KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.16437 BF_2 123.00 3.02 1990 642913935 XP_008201220.1 1315 4.2e-142 PREDICTED: nucleoporin NDC1 isoform X1 [Tribolium castaneum]>gi|642913937|ref|XP_008201221.1| PREDICTED: nucleoporin NDC1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q298S5 410 1.5e-38 Nucleoporin Ndc1 OS=Drosophila pseudoobscura pseudoobscura GN=Ndc1 PE=3 SV=1 PF08710 nsp9 replicase GO:0019079 viral genome replication GO:0003723 RNA binding -- -- KOG4358 Uncharacterized conserved protein Cluster-8309.16438 BF_2 48.22 0.88 2571 270001272 EEZ97719.1 1370 2.3e-148 hypothetical protein TcasGA2_TC011198 [Tribolium castaneum] -- -- -- -- -- K04224 TACR3 tachykinin receptor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04224 P30975 1030 2.5e-110 Tachykinin-like peptides receptor 99D OS=Drosophila melanogaster GN=TkR99D PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4219 G protein-coupled receptor Cluster-8309.16441 BF_2 3.00 0.41 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16442 BF_2 152.59 3.22 2267 817054390 XP_012267339.1 1888 1.7e-208 PREDICTED: organic cation transporter protein-like [Athalia rosae] 815793565 XM_012361984.1 64 2.70708e-22 PREDICTED: Linepithema humile uncharacterized LOC105669183 (LOC105669183), mRNA -- -- -- -- Q9Y226 614 3.8e-62 Solute carrier family 22 member 13 OS=Homo sapiens GN=SLC22A13 PE=2 SV=2 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.16443 BF_2 3.00 0.37 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16447 BF_2 14.00 0.52 1411 115443597 YP_778616.1 313 4.7e-26 cytochrome b559 a subunit [Bigelowiella natans]>gi|122221269|sp|Q06J11.1|PSBE_BIGNA RecName: Full=Cytochrome b559 subunit alpha; AltName: Full=PSII reaction center subunit V (chloroplast) [Bigelowiella natans]>gi|110810242|gb|ABG91448.1| cytochrome b559 a subunit [Bigelowiella natans] 309321413 HQ336405.1 1033 0 Prunus persica chloroplast, complete genome -- -- -- -- P0C369 431 4.0e-41 Cytochrome b559 subunit alpha OS=Oryza sativa subsp. indica GN=psbE PE=3 SV=1 PF00283//PF00284//PF02419//PF01788 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit//PsbL protein//PsbJ GO:0009767//GO:0015979 photosynthetic electron transport chain//photosynthesis GO:0020037//GO:0046872 heme binding//metal ion binding GO:0016020//GO:0009535//GO:0009523//GO:0009539//GO:0030096//GO:0016021 membrane//chloroplast thylakoid membrane//photosystem II//photosystem II reaction center//plasma membrane-derived thylakoid photosystem II//integral component of membrane -- -- Cluster-8309.16451 BF_2 194.72 7.77 1335 478260192 ENN79965.1 695 2.2e-70 hypothetical protein YQE_03611, partial [Dendroctonus ponderosae] -- -- -- -- -- K13248 PHOSPHO2 pyridoxal phosphate phosphatase PHOSPHO2 http://www.genome.jp/dbget-bin/www_bget?ko:K13248 Q66KD6 401 1.1e-37 Probable phosphatase phospho2 OS=Xenopus tropicalis GN=phospho2 PE=2 SV=1 PF02358//PF06888 Trehalose-phosphatase//Putative Phosphatase GO:0008152//GO:0005992 metabolic process//trehalose biosynthetic process GO:0003824//GO:0016791 catalytic activity//phosphatase activity -- -- KOG3120 Predicted haloacid dehalogenase-like hydrolase Cluster-8309.16452 BF_2 4.00 0.60 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16455 BF_2 3.00 1.21 389 752884323 XP_011259899.1 505 7.0e-49 PREDICTED: putative uncharacterized protein FLJ37770 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q3ZCU0 228 3.8e-18 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16458 BF_2 19.19 0.32 2766 546678918 ERL89456.1 328 1.7e-27 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 97 1.49704e-40 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q7KQZ4 197 1.1e-13 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16464 BF_2 14.00 0.75 1065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16465 BF_2 3.00 0.39 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16468 BF_2 7.00 0.53 838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02792 Mago nashi protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.16469 BF_2 328.60 5.69 2702 91091782 XP_969684.1 2845 0.0e+00 PREDICTED: cell division cycle 5-like protein [Tribolium castaneum]>gi|270001087|gb|EEZ97534.1| hypothetical protein TcasGA2_TC011382 [Tribolium castaneum] 807017652 XM_004518985.2 277 1.26906e-140 PREDICTED: Ceratitis capitata cell division cycle 5-like protein (LOC101451004), mRNA K12860 CDC5L, CDC5, CEF1 pre-mRNA-splicing factor CDC5/CEF1 http://www.genome.jp/dbget-bin/www_bget?ko:K12860 O08837 2223 1.2e-248 Cell division cycle 5-like protein OS=Rattus norvegicus GN=Cdc5l PE=1 SV=2 PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0030168 protein polymerization//signal transduction//platelet activation GO:0030674//GO:0005488//GO:0005102 protein binding, bridging//binding//receptor binding GO:0005577 fibrinogen complex KOG0050 mRNA splicing protein CDC5 (Myb superfamily) Cluster-8309.16471 BF_2 14.92 0.42 1765 642915229 XP_008190531.1 772 3.5e-79 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 482 6.1e-47 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16479 BF_2 17.09 0.37 2203 642920972 XP_008192636.1 240 2.1e-17 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16482 BF_2 81.24 3.25 1334 478258693 ENN78728.1 180 1.2e-10 hypothetical protein YQE_04800, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27593 153 6.5e-09 Cytochrome P450 6a8 OS=Drosophila melanogaster GN=Cyp6a8 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.16483 BF_2 10.00 1.32 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16486 BF_2 102.64 1.52 3119 478256280 ENN76470.1 950 1.4e-99 hypothetical protein YQE_06924, partial [Dendroctonus ponderosae] 488547849 XM_004465365.1 61 1.73914e-20 PREDICTED: Dasypus novemcinctus SYF2 pre-mRNA-splicing factor (SYF2), mRNA K12868 SYF2 pre-mRNA-splicing factor SYF2 http://www.genome.jp/dbget-bin/www_bget?ko:K12868 Q28XK6 748 1.5e-77 Pre-mRNA-splicing factor Syf2 OS=Drosophila pseudoobscura pseudoobscura GN=Syf2 PE=3 SV=1 PF06839//PF03079//PF01529//PF03405//PF00199//PF10237//PF00098 GRF zinc finger//ARD/ARD' family//DHHC palmitoyltransferase//Fatty acid desaturase//Catalase//Probable N6-adenine methyltransferase//Zinc knuckle GO:0015947//GO:0006979//GO:0006804//GO:0006568//GO:0006631//GO:0055114 methane metabolic process//response to oxidative stress//obsolete peroxidase reaction//tryptophan metabolic process//fatty acid metabolic process//oxidation-reduction process GO:0010309//GO:0045300//GO:0004096//GO:0003676//GO:0008168//GO:0008270//GO:0020037 acireductone dioxygenase [iron(II)-requiring] activity//acyl-[acyl-carrier-protein] desaturase activity//catalase activity//nucleic acid binding//methyltransferase activity//zinc ion binding//heme binding -- -- KOG2609 Cyclin D-interacting protein GCIP Cluster-8309.16487 BF_2 201.36 3.04 3059 478257683 ENN77830.1 1530 7.7e-167 hypothetical protein YQE_05713, partial [Dendroctonus ponderosae] 488547849 XM_004465365.1 61 1.7053e-20 PREDICTED: Dasypus novemcinctus SYF2 pre-mRNA-splicing factor (SYF2), mRNA -- -- -- -- Q9H5U6 966 7.9e-103 Zinc finger CCHC domain-containing protein 4 OS=Homo sapiens GN=ZCCHC4 PE=1 SV=3 PF03079//PF06839//PF00098//PF10237//PF01529//PF00199 ARD/ARD' family//GRF zinc finger//Zinc knuckle//Probable N6-adenine methyltransferase//DHHC palmitoyltransferase//Catalase GO:0006568//GO:0055114//GO:0015947//GO:0006979//GO:0006804 tryptophan metabolic process//oxidation-reduction process//methane metabolic process//response to oxidative stress//obsolete peroxidase reaction GO:0003676//GO:0008270//GO:0008168//GO:0020037//GO:0010309//GO:0004096 nucleic acid binding//zinc ion binding//methyltransferase activity//heme binding//acireductone dioxygenase [iron(II)-requiring] activity//catalase activity -- -- KOG2609 Cyclin D-interacting protein GCIP Cluster-8309.16490 BF_2 34.00 2.23 924 -- -- -- -- -- 528540458 AP012528.1 767 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16494 BF_2 8.00 5.69 340 675304825 AIL82417.1 286 1.5e-23 UNVERIFIED: ubiquitin-ribosomal protein S27a, partial [Mytilus trossulus] 116640704 CT830068.1 295 1.4422e-151 Oryza sativa (indica cultivar-group) cDNA clone:OSIGCSN031D14, full insert sequence K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P51431 367 2.5e-34 Ubiquitin-40S ribosomal protein S27a-2 OS=Oryza sativa subsp. japonica GN=RPS27AB PE=2 SV=3 PF01599 Ribosomal protein S27a GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.16495 BF_2 42.04 0.54 3543 642919497 XP_008191896.1 2771 1.1e-310 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.16498 BF_2 11.00 2.47 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16500 BF_2 40.90 0.70 2734 642925371 XP_008194521.1 312 1.2e-25 PREDICTED: zinc finger protein 600-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 222 1.3e-16 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF04988//PF13465//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.16501 BF_2 1.00 0.62 350 307168739 EFN61742.1 239 4.4e-18 hypothetical protein EAG_13055, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16505 BF_2 167.00 6.46 1369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.16507 BF_2 101.79 4.27 1285 546673280 ERL84916.1 258 1.0e-19 hypothetical protein D910_02339 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.16509 BF_2 382.72 8.16 2248 189236049 XP_001809395.1 699 1.3e-70 PREDICTED: tudor domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- K18404 TDRD3 tudor domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18404 Q5ZMS6 412 1.0e-38 Tudor domain-containing protein 3 OS=Gallus gallus GN=TDRD3 PE=2 SV=1 PF06003//PF09103 Survival motor neuron protein (SMN)//BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 GO:0000724//GO:0006397 double-strand break repair via homologous recombination//mRNA processing GO:0003723 RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG3683 Uncharacterized conserved protein Cluster-8309.16511 BF_2 8.00 1.12 585 343887450 NP_001230627.1 663 5.0e-67 acireductone dioxygenase 1 [Sus scrofa] 645235385 XM_008226021.1 334 5.40657e-173 PREDICTED: Prunus mume 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 (LOC103323990), mRNA K08967 mtnD, mtnZ, ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K08967 F6HDT7 914 1.6e-97 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 2 OS=Vitis vinifera GN=VIT_05s0020g04080 PE=3 SV=1 PF03079//PF02311//PF00190 ARD/ARD' family//AraC-like ligand binding domain//Cupin GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0045735//GO:0010309 nutrient reservoir activity//acireductone dioxygenase [iron(II)-requiring] activity -- -- KOG2107 Uncharacterized conserved protein, contains double-stranded beta-helix domain Cluster-8309.16513 BF_2 2.59 0.61 466 4530036 AAD21827.1 154 4.2e-08 chymotrypsin-like serine protease [Ctenocephalides felis] -- -- -- -- -- -- -- -- -- Q9Y5K2 124 5.2e-06 Kallikrein-4 OS=Homo sapiens GN=KLK4 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.16514 BF_2 130.00 25.30 502 15420657 AAK97411.1 218 1.7e-15 serine protease-like protein [Anthonomus grandis] -- -- -- -- -- -- -- -- -- Q3UP87 150 5.4e-09 Neutrophil elastase OS=Mus musculus GN=Elane PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.16516 BF_2 13.62 0.85 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16520 BF_2 159.97 6.44 1326 642912029 XP_008199066.1 1100 2.4e-117 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 270 1.7e-22 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF02460//PF03176//PF00873 Patched family//MMPL family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.16523 BF_2 27.00 0.63 2068 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16525 BF_2 26.39 0.36 3376 332374404 AEE62343.1 777 1.7e-79 unknown [Dendroctonus ponderosae] -- -- -- -- -- K07071 K07071 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K07071 Q17QH8 502 5.6e-49 Epimerase family protein SDR39U1 OS=Bos taurus GN=SDR39U1 PE=2 SV=1 PF00070//PF00705//PF07650//PF01370//PF03184 Pyridine nucleotide-disulphide oxidoreductase//Proliferating cell nuclear antigen, N-terminal domain//KH domain//NAD dependent epimerase/dehydratase family//DDE superfamily endonuclease GO:0006275//GO:0055114 regulation of DNA replication//oxidation-reduction process GO:0050662//GO:0003824//GO:0003723//GO:0003677//GO:0016491//GO:0003676 coenzyme binding//catalytic activity//RNA binding//DNA binding//oxidoreductase activity//nucleic acid binding -- -- KOG3019 Predicted nucleoside-diphosphate sugar epimerase Cluster-8309.16526 BF_2 7.00 0.50 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16527 BF_2 8.00 0.34 1278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16528 BF_2 22.67 1.51 917 642925157 XP_967086.2 712 1.6e-72 PREDICTED: DNA-directed RNA polymerase II subunit RPB9 [Tribolium castaneum] 751463391 XM_011188291.1 154 9.98113e-73 PREDICTED: Bactrocera cucurbitae DNA-directed RNA polymerase II subunit RPB9 (LOC105214718), mRNA K03017 RPB9, POLR2I DNA-directed RNA polymerase II subunit RPB9 http://www.genome.jp/dbget-bin/www_bget?ko:K03017 P36958 633 9.7e-65 DNA-directed RNA polymerase II subunit RPB9 OS=Drosophila melanogaster GN=RpII15 PE=2 SV=2 PF01396//PF00130//PF01667//PF02150//PF01096 Topoisomerase DNA binding C4 zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ribosomal protein S27//RNA polymerases M/15 Kd subunit//Transcription factor S-II (TFIIS) GO:0042254//GO:0035556//GO:0006265//GO:0006206//GO:0006144//GO:0006412//GO:0006351 ribosome biogenesis//intracellular signal transduction//DNA topological change//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//translation//transcription, DNA-templated GO:0008270//GO:0003735//GO:0003899//GO:0003676//GO:0003916//GO:0003677 zinc ion binding//structural constituent of ribosome//DNA-directed RNA polymerase activity//nucleic acid binding//DNA topoisomerase activity//DNA binding GO:0005730//GO:0005840//GO:0005622//GO:0005694 nucleolus//ribosome//intracellular//chromosome KOG2691 RNA polymerase II subunit 9 Cluster-8309.16530 BF_2 6.00 0.38 941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16537 BF_2 10.00 0.53 1074 546682957 ERL92836.1 201 3.4e-13 hypothetical protein D910_10143 [Dendroctonus ponderosae] -- -- -- -- -- K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 196 5.4e-14 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.16538 BF_2 22.04 0.80 1440 332373478 AEE61880.1 814 3.8e-84 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 487 1.3e-47 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04263//PF04265//PF01341 Thiamin pyrophosphokinase, catalytic domain//Thiamin pyrophosphokinase, vitamin B1 binding domain//Glycosyl hydrolases family 6 GO:0030245//GO:0005975//GO:0009229//GO:0006772 cellulose catabolic process//carbohydrate metabolic process//thiamine diphosphate biosynthetic process//thiamine metabolic process GO:0030975//GO:0004788//GO:0005524//GO:0004553 thiamine binding//thiamine diphosphokinase activity//ATP binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.16540 BF_2 31.71 0.52 2836 270015294 EFA11742.1 1592 4.6e-174 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.16542 BF_2 25.40 0.31 3744 189237671 XP_967514.2 597 1.4e-58 PREDICTED: mitochondrial intermembrane space import and assembly protein 40 [Tribolium castaneum] -- -- -- -- -- K10841 ERCC6, CSB, RAD26 DNA excision repair protein ERCC-6 http://www.genome.jp/dbget-bin/www_bget?ko:K10841 Q03468 397 9.2e-37 DNA excision repair protein ERCC-6 OS=Homo sapiens GN=ERCC6 PE=1 SV=1 PF04851//PF00176 Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) Cluster-8309.16544 BF_2 32.00 8.25 449 170063379 XP_001867078.1 317 5.1e-27 serine 3-dehydrogenase [Culex quinquefasciatus]>gi|167881022|gb|EDS44405.1| serine 3-dehydrogenase [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- D2WKD9 286 8.2e-25 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.16545 BF_2 16.00 12.43 334 642925814 XP_970128.3 327 2.6e-28 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 205 1.5e-15 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01073//PF05531//PF00106//PF01370//PF12242 3-beta hydroxysteroid dehydrogenase/isomerase family//Nucleopolyhedrovirus P10 protein//short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008210//GO:0008152//GO:0008209//GO:0055114//GO:0006694//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0003824//GO:0050662//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0019028 viral capsid -- -- Cluster-8309.16553 BF_2 6.91 0.54 821 642917307 XP_008199245.1 237 1.8e-17 PREDICTED: disco-interacting protein 2 isoform X6 [Tribolium castaneum] 821000632 XM_012499594.1 35 1.26162e-06 PREDICTED: Nomascus leucogenys DIP2 disco-interacting protein 2 homolog C (Drosophila) (DIP2C), mRNA -- -- -- -- Q6NVJ5 178 5.0e-12 Disco-interacting protein 2 homolog B-A OS=Danio rerio GN=dip2ba PE=2 SV=1 PF01297//PF06464 Zinc-uptake complex component A periplasmic//DMAP1-binding Domain GO:0030001 metal ion transport GO:0008134//GO:0046872 transcription factor binding//metal ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3628 Predicted AMP-binding protein Cluster-8309.16555 BF_2 2.37 0.33 592 645040646 XP_008210807.1 314 1.5e-26 PREDICTED: uncharacterized protein LOC100117040 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16556 BF_2 18.15 0.47 1920 642920562 XP_001816430.2 1281 3.6e-138 PREDICTED: uncharacterized protein LOC100141961 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 Q9Z0M5 452 2.0e-43 Lysosomal acid lipase/cholesteryl ester hydrolase OS=Mus musculus GN=Lipa PE=2 SV=2 PF04083//PF01764//PF01738 Partial alpha/beta-hydrolase lipase region//Lipase (class 3)//Dienelactone hydrolase family GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.16562 BF_2 356.37 4.87 3349 91077078 XP_969608.1 3786 0.0e+00 PREDICTED: integrator complex subunit 7 [Tribolium castaneum] -- -- -- -- -- K13144 INTS7 integrator complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13144 Q9NVH2 1659 3.8e-183 Integrator complex subunit 7 OS=Homo sapiens GN=INTS7 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1988 Uncharacterized conserved protein Cluster-8309.16563 BF_2 77.05 3.11 1325 642938395 XP_971552.2 690 8.4e-70 PREDICTED: probable oligoribonuclease isoform X1 [Tribolium castaneum] -- -- -- -- -- K13288 orn, REX2, REXO2 oligoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K13288 Q9Y3B8 550 5.9e-55 Oligoribonuclease, mitochondrial OS=Homo sapiens GN=REXO2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3242 Oligoribonuclease (3'->5' exoribonuclease) Cluster-8309.16566 BF_2 133.46 4.17 1625 91094771 XP_967866.1 1686 3.3e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.2e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.16568 BF_2 7.00 0.70 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16569 BF_2 1.00 0.34 410 325303418 DAA34128.1 469 1.1e-44 TPA_exp: radixin [Amblyomma variegatum] 612057656 XM_007506955.1 95 2.6768e-40 PREDICTED: Monodelphis domestica moesin (MSN), mRNA K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 P26043 445 2.7e-43 Radixin OS=Mus musculus GN=Rdx PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.16573 BF_2 11.50 0.67 1005 751233566 XP_011170470.1 163 8.2e-09 PREDICTED: uncharacterized protein LOC105203380 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16576 BF_2 13.00 0.39 1668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16577 BF_2 399.00 13.67 1508 270013613 EFA10061.1 1077 1.3e-114 hypothetical protein TcasGA2_TC012235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 517 4.5e-51 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.16578 BF_2 26.19 0.61 2078 571330974 AHF27419.1 1465 1.8e-159 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q17NV8 752 3.5e-78 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF07690//PF00083//PF01229 Major Facilitator Superfamily//Sugar (and other) transporter//Glycosyl hydrolases family 39 GO:0005975//GO:0055085 carbohydrate metabolic process//transmembrane transport GO:0004553//GO:0022857 hydrolase activity, hydrolyzing O-glycosyl compounds//transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.16579 BF_2 257.09 8.05 1623 642919257 XP_008191796.1 1329 8.3e-144 PREDICTED: glucosamine-6-phosphate isomerase isoform X1 [Tribolium castaneum]>gi|642919259|ref|XP_008191797.1| PREDICTED: glucosamine-6-phosphate isomerase isoform X1 [Tribolium castaneum] 195473851 XM_002089170.1 181 1.75677e-87 Drosophila yakuba GE25482 (Dyak\GE25482), partial mRNA K02564 nagB, GNPDA glucosamine-6-phosphate deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K02564 Q16HW7 1213 9.6e-132 Glucosamine-6-phosphate isomerase OS=Aedes aegypti GN=Gnpda1 PE=3 SV=1 PF08022//PF01182 FAD-binding domain//Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase GO:0055114//GO:0005975 oxidation-reduction process//carbohydrate metabolic process GO:0016491 oxidoreductase activity -- -- KOG3148 Glucosamine-6-phosphate isomerase Cluster-8309.16581 BF_2 25.18 0.38 3037 300394168 ADK11710.1 671 3.1e-67 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q32LQ0 512 3.5e-50 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.16583 BF_2 72.00 5.90 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16584 BF_2 52.00 4.23 801 478252911 ENN73295.1 495 2.1e-47 hypothetical protein YQE_10059, partial [Dendroctonus ponderosae] -- -- -- -- -- K14525 RPP25 ribonucleases P/MRP protein subunit RPP25 http://www.genome.jp/dbget-bin/www_bget?ko:K14525 Q8N5L8 283 3.3e-24 Ribonuclease P protein subunit p25-like protein OS=Homo sapiens GN=RPP25L PE=1 SV=1 PF01918 Alba -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16585 BF_2 3.00 1.30 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16586 BF_2 5.57 0.89 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16588 BF_2 180.71 8.36 1191 332373854 AEE62068.1 1398 6.0e-152 unknown [Dendroctonus ponderosae] 642918806 XM_008193372.1 169 5.9922e-81 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase PP1-alpha-like (LOC103312533), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 P61287 1196 6.6e-130 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Bos taurus GN=PPP1CC PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.16590 BF_2 2.00 0.70 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16592 BF_2 59.36 1.07 2611 642917912 XP_008191379.1 989 3.5e-104 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 531 1.9e-52 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101//PF04587 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain//ADP-specific Phosphofructokinase/Glucokinase conserved region GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016758//GO:0016773 transferase activity, transferring hexosyl groups//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.16596 BF_2 497.52 3.14 6905 642938901 XP_008195529.1 2936 0.0e+00 PREDICTED: FCH and double SH3 domains protein 2 [Tribolium castaneum]>gi|270016165|gb|EFA12613.1| hypothetical protein TcasGA2_TC006854 [Tribolium castaneum] 158286862 XM_308970.4 176 4.56991e-84 Anopheles gambiae str. PEST AGAP006774-PA (AgaP_AGAP006774) mRNA, complete cds -- -- -- -- O94868 971 4.7e-103 F-BAR and double SH3 domains protein 2 OS=Homo sapiens GN=FCHSD2 PE=1 SV=3 PF12601//PF01997//PF14604//PF00018 Rubivirus non-structural protein//Translin family//Variant SH3 domain//SH3 domain GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0005515//GO:0004197//GO:0017111//GO:0016817//GO:0003968//GO:0043565 protein binding//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//hydrolase activity, acting on acid anhydrides//RNA-directed RNA polymerase activity//sequence-specific DNA binding GO:0031379 RNA-directed RNA polymerase complex KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.16597 BF_2 25.47 0.35 3298 642927336 XP_974968.2 1026 2.3e-108 PREDICTED: protein prune homolog 2 [Tribolium castaneum] -- -- -- -- -- K18449 PRUNE2, BMCC1 prune homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18449 Q5BJR4 507 1.4e-49 Protein prune homolog 2 OS=Rattus norvegicus GN=Prune2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16599 BF_2 13.42 0.32 2067 642927336 XP_974968.2 945 3.5e-99 PREDICTED: protein prune homolog 2 [Tribolium castaneum] -- -- -- -- -- K18449 PRUNE2, BMCC1 prune homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18449 Q5BJR4 507 9.0e-50 Protein prune homolog 2 OS=Rattus norvegicus GN=Prune2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16601 BF_2 175.00 35.54 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16603 BF_2 3.00 0.77 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16604 BF_2 4.00 1.03 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16609 BF_2 104.00 7.09 901 91091246 XP_968473.1 511 3.3e-49 PREDICTED: RWD domain-containing protein 4 [Tribolium castaneum]>gi|270014113|gb|EFA10561.1| hypothetical protein TcasGA2_TC012817 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CPR1 330 1.3e-29 RWD domain-containing protein 4 OS=Mus musculus GN=Rwdd4 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.16611 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16612 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16614 BF_2 26.85 0.56 2299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1662 BF_2 11.00 0.42 1387 617298650 XP_007549979.1 1311 8.6e-142 PREDICTED: malate dehydrogenase, mitochondrial [Poecilia formosa]>gi|617298657|ref|XP_007550217.1| PREDICTED: malate dehydrogenase, mitochondrial [Poecilia formosa] 262401156 FJ774760.1 541 0 Scylla paramamosain malate dehydrogenase mRNA, partial cds K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 Q5NVR2 1270 2.0e-138 Malate dehydrogenase, mitochondrial OS=Pongo abelii GN=MDH2 PE=2 SV=1 PF01073//PF01118//PF02866//PF02882//PF00056 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008210//GO:0009396//GO:0046487//GO:0008207//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0003824//GO:0003854//GO:0016491//GO:0004488//GO:0016616//GO:0051287//GO:0016620 catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.16621 BF_2 5.62 0.37 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16622 BF_2 5.00 0.54 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03558 TBSV core protein P21/P22 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.16623 BF_2 295.60 7.05 2040 385843184 AFI80889.1 1884 4.6e-208 GluCl alpha subunit [Phyllotreta striolata] 768446852 XM_011567086.1 319 4.28748e-164 PREDICTED: Plutella xylostella glutamate-gated chloride channel-like (LOC105395149), partial mRNA K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1685 2.2e-186 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.16624 BF_2 58.73 3.69 953 642911282 XP_008199355.1 834 1.2e-86 PREDICTED: glutamate-gated chloride channel isoform X5 [Tribolium castaneum] -- -- -- -- -- K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 670 5.2e-69 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.16625 BF_2 16.33 0.69 1275 385843184 AFI80889.1 274 1.4e-21 GluCl alpha subunit [Phyllotreta striolata] -- -- -- -- -- K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 168 1.1e-10 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16630 BF_2 8.46 0.39 1205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16632 BF_2 3.00 0.50 540 270001667 EEZ98114.1 270 1.7e-21 hypothetical protein TcasGA2_TC000532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16635 BF_2 103.07 1.18 3939 189241548 XP_971070.2 613 2.1e-60 PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|642936933|ref|XP_008194513.1| PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|270001278|gb|EEZ97725.1| spatzle 5 [Tribolium castaneum] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q00420 454 2.4e-43 GA-binding protein subunit beta-1 OS=Mus musculus GN=Gabpb1 PE=1 SV=2 PF02984//PF13606//PF13869//PF00293//PF00023 Cyclin, C-terminal domain//Ankyrin repeat//Nucleotide hydrolase//NUDIX domain//Ankyrin repeat GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729//GO:0005515 hydrolase activity//mRNA binding//protein binding GO:0005634//GO:0005849 nucleus//mRNA cleavage factor complex -- -- Cluster-8309.16636 BF_2 174.49 1.86 4222 189241548 XP_971070.2 659 1.1e-65 PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|642936933|ref|XP_008194513.1| PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|270001278|gb|EEZ97725.1| spatzle 5 [Tribolium castaneum] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q00420 454 2.6e-43 GA-binding protein subunit beta-1 OS=Mus musculus GN=Gabpb1 PE=1 SV=2 PF02984//PF00023//PF13606//PF13869//PF00293 Cyclin, C-terminal domain//Ankyrin repeat//Ankyrin repeat//Nucleotide hydrolase//NUDIX domain GO:0006378 mRNA polyadenylation GO:0003729//GO:0005515//GO:0016787 mRNA binding//protein binding//hydrolase activity GO:0005634//GO:0005849 nucleus//mRNA cleavage factor complex -- -- Cluster-8309.16637 BF_2 33.55 0.33 4565 157115864 XP_001658319.1 608 9.3e-60 AAEL007364-PA [Aedes aegypti]>gi|108876729|gb|EAT40954.1| AAEL007364-PA [Aedes aegypti] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q502K3 254 4.3e-20 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Danio rerio GN=ankrd52 PE=2 SV=1 PF00023//PF00293//PF13869//PF13606//PF02984 Ankyrin repeat//NUDIX domain//Nucleotide hydrolase//Ankyrin repeat//Cyclin, C-terminal domain GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729//GO:0005515 hydrolase activity//mRNA binding//protein binding GO:0005634//GO:0005849 nucleus//mRNA cleavage factor complex -- -- Cluster-8309.16638 BF_2 274.65 3.38 3690 189237424 XP_974277.2 2091 8.2e-232 PREDICTED: cGMP-dependent protein kinase 1-like [Tribolium castaneum] -- -- -- -- -- K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03042 1406 9.1e-154 cGMP-dependent protein kinase, isozyme 1 OS=Drosophila melanogaster GN=Pkg21D PE=1 SV=2 PF00069//PF03153//PF07714 Protein kinase domain//Transcription factor IIA, alpha/beta subunit//Protein tyrosine kinase GO:0006468//GO:0006367 protein phosphorylation//transcription initiation from RNA polymerase II promoter GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005672 transcription factor TFIIA complex KOG0614 cGMP-dependent protein kinase Cluster-8309.16639 BF_2 93.35 1.69 2599 189237424 XP_974277.2 1964 3.1e-217 PREDICTED: cGMP-dependent protein kinase 1-like [Tribolium castaneum] -- -- -- -- -- K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03042 1366 2.8e-149 cGMP-dependent protein kinase, isozyme 1 OS=Drosophila melanogaster GN=Pkg21D PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.16644 BF_2 15.09 0.47 1623 546686050 ERL95450.1 207 1.0e-13 hypothetical protein D910_12712 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16646 BF_2 12.00 0.35 1708 731513203 XP_010599760.1 331 4.6e-28 PREDICTED: zinc finger protein 345-like isoform X2 [Loxodonta africana] 617460738 XM_007571845.1 34 9.64298e-06 PREDICTED: Poecilia formosa gastrula zinc finger protein XlCGF57.1-like (LOC103151666), mRNA K05706 SNAI2, SLUG snail 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05706 Q96MU6 326 7.2e-29 Zinc finger protein 778 OS=Homo sapiens GN=ZNF778 PE=1 SV=3 PF00096//PF13465//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.16648 BF_2 183.21 8.29 1212 91076406 XP_969383.1 1218 4.6e-131 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P80276 781 8.9e-82 Aldose reductase OS=Sus scrofa GN=AKR1B1 PE=1 SV=2 PF01729 Quinolinate phosphoribosyl transferase, C-terminal domain GO:0055114//GO:0046497//GO:0009435 oxidation-reduction process//nicotinate nucleotide metabolic process//NAD biosynthetic process GO:0004514//GO:0016491 nicotinate-nucleotide diphosphorylase (carboxylating) activity//oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.1665 BF_2 4.00 0.46 649 262401375 ACY66590.1 309 6.2e-26 hypothetical protein [Scylla paramamosain] 262401374 FJ774869.1 622 0 Scylla paramamosain hypothetical protein mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16650 BF_2 451.64 9.03 2379 646705367 KDR13121.1 1953 5.3e-216 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 [Zootermopsis nevadensis] 617382302 XM_007546837.1 113 1.63989e-49 PREDICTED: Poecilia formosa SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 (smarcd1), mRNA K11650 SMARCD SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D http://www.genome.jp/dbget-bin/www_bget?ko:K11650 Q9VYG2 1768 6.2e-196 Brahma-associated protein of 60 kDa OS=Drosophila melanogaster GN=Bap60 PE=1 SV=1 PF02201 SWIB/MDM2 domain -- -- GO:0005515 protein binding -- -- KOG2570 SWI/SNF transcription activation complex subunit Cluster-8309.16652 BF_2 50.16 0.54 4205 642934412 XP_008197650.1 541 5.1e-52 PREDICTED: transformer-2 protein homolog beta isoform X1 [Tribolium castaneum] 642934413 XM_008199429.1 299 1.16929e-152 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X2, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 3.7e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.16657 BF_2 8.00 0.45 1032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16661 BF_2 11.00 9.86 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05162 Ribosomal protein L41 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.16663 BF_2 8.00 0.56 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16666 BF_2 101.36 1.04 4360 270009849 EFA06297.1 1167 1.4e-124 hypothetical protein TcasGA2_TC009164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AKG8 300 1.9e-25 Focadhesin OS=Mus musculus GN=Focad PE=2 SV=1 PF01105//PF08685 emp24/gp25L/p24 family/GOLD//GON domain GO:0006810 transport GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.16667 BF_2 463.00 9.85 2253 642930006 XP_008196062.1 875 5.1e-91 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NFP1 374 2.6e-34 Vanin-like protein 1 OS=Drosophila melanogaster GN=CG32754 PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.16671 BF_2 1.79 0.51 433 91088681 XP_974930.1 220 8.6e-16 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0005488 binding -- -- -- -- Cluster-8309.16674 BF_2 2.00 0.32 546 795010007 XP_011864749.1 182 2.8e-11 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13443//PF13404//PF01047//PF09339 Cro/C1-type HTH DNA-binding domain//AsnC-type helix-turn-helix domain//MarR family//IclR helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.16676 BF_2 119.00 9.36 819 478253188 ENN73559.1 530 1.9e-51 hypothetical protein YQE_09809, partial [Dendroctonus ponderosae]>gi|546678937|gb|ERL89475.1| hypothetical protein D910_06841 [Dendroctonus ponderosae] -- -- -- -- -- K02990 RP-S6, MRPS6, rpsF small subunit ribosomal protein S6 http://www.genome.jp/dbget-bin/www_bget?ko:K02990 Q9VZD5 419 5.7e-40 Probable 28S ribosomal protein S6, mitochondrial OS=Drosophila melanogaster GN=mRpS6 PE=2 SV=1 PF01250//PF03484 Ribosomal protein S6//tRNA synthetase B5 domain GO:0042254//GO:0006412//GO:0006432 ribosome biogenesis//translation//phenylalanyl-tRNA aminoacylation GO:0000287//GO:0019843//GO:0003735//GO:0005524//GO:0003723 magnesium ion binding//rRNA binding//structural constituent of ribosome//ATP binding//RNA binding GO:0005840 ribosome KOG4708 Mitochondrial ribosomal protein MRP17 Cluster-8309.16678 BF_2 9.00 2.11 465 507666134 XP_004707497.1 217 2.1e-15 PREDICTED: receptor tyrosine-protein kinase erbB-2 [Echinops telfairi] 54888662 CR626867.6 465 0 Human DNA sequence from clone XX-HCC1954_8J23, complete sequence K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 O18735 206 1.6e-15 Receptor tyrosine-protein kinase erbB-2 OS=Canis familiaris GN=ERBB2 PE=2 SV=1 PF07714//PF11770//PF00069//PF04995 Protein tyrosine kinase//GRB2-binding adapter (GAPT)//Protein kinase domain//Heme exporter protein D (CcmD) GO:0017004//GO:0015886//GO:0006468 cytochrome complex assembly//heme transport//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.16680 BF_2 9.55 0.31 1595 675376006 KFM68908.1 181 1.1e-10 hypothetical protein X975_14817, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16681 BF_2 2.00 4.01 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16683 BF_2 9.71 2.31 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16685 BF_2 28.59 0.33 3932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16687 BF_2 55.91 0.63 4019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16688 BF_2 2.00 0.74 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16689 BF_2 5.00 0.56 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16690 BF_2 68.27 0.55 5513 270013163 EFA09611.1 936 1.0e-97 hypothetical protein TcasGA2_TC011732 [Tribolium castaneum] 194880702 XM_001974468.1 91 6.50124e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF00041//PF16656//PF08022 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//FAD-binding domain GO:0006771//GO:0055114//GO:0019497 riboflavin metabolic process//oxidation-reduction process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0016491//GO:0046872 acid phosphatase activity//protein binding//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.16693 BF_2 190.00 8.47 1225 646719319 KDR21474.1 619 1.3e-61 28S ribosomal protein S24, mitochondrial, partial [Zootermopsis nevadensis] -- -- -- -- -- K17403 MRPS24 small subunit ribosomal protein S24 http://www.genome.jp/dbget-bin/www_bget?ko:K17403 Q9VCC3 579 2.4e-58 28S ribosomal protein S24, mitochondrial OS=Drosophila melanogaster GN=mRpS24 PE=3 SV=1 PF14955 Mitochondrial ribosome subunit S24 -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.16701 BF_2 113.00 2.75 2003 642939427 XP_008200386.1 575 2.7e-56 PREDICTED: uncharacterized protein LOC103314904 [Tribolium castaneum]>gi|270016505|gb|EFA12951.1| hypothetical protein TcasGA2_TC005071 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0BLU1 362 5.7e-33 E3 ubiquitin-protein ligase RNF168 OS=Xenopus tropicalis GN=rnf168 PE=2 SV=1 PF16685//PF13639//PF00097//PF14634//PF12678 zinc RING finger of MSL2//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-H2 zinc finger -- -- GO:0008270//GO:0005515//GO:0046872//GO:0061630 zinc ion binding//protein binding//metal ion binding//ubiquitin protein ligase activity -- -- -- -- Cluster-8309.16708 BF_2 41.00 2.27 1044 642916815 XP_008199513.1 647 6.4e-65 PREDICTED: tRNA-splicing endonuclease subunit Sen34 [Tribolium castaneum] -- -- -- -- -- K15323 TSEN34 tRNA-splicing endonuclease subunit Sen34 http://www.genome.jp/dbget-bin/www_bget?ko:K15323 Q9BSV6 238 7.0e-19 tRNA-splicing endonuclease subunit Sen34 OS=Homo sapiens GN=TSEN34 PE=1 SV=1 PF01974 tRNA intron endonuclease, catalytic C-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213 tRNA-intron endonuclease activity GO:0000214 tRNA-intron endonuclease complex KOG4133 tRNA splicing endonuclease Cluster-8309.16709 BF_2 77.22 0.62 5530 642939444 XP_008200394.1 1205 6.7e-129 PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939446|ref|XP_008200396.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939448|ref|XP_008200397.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939450|ref|XP_008200398.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum] 642939445 XM_008202174.1 38 1.89182e-07 PREDICTED: Tribolium castaneum transcription factor E2F2-like (LOC656396), transcript variant X2, mRNA K06620 E2F3 transcription factor E2F3 http://www.genome.jp/dbget-bin/www_bget?ko:K06620 O00716 437 3.1e-41 Transcription factor E2F3 OS=Homo sapiens GN=E2F3 PE=1 SV=1 PF01991//PF02319 ATP synthase (E/31 kDa) subunit//E2F/DP family winged-helix DNA-binding domain GO:0015992//GO:0006355//GO:0015991//GO:0006119 proton transport//regulation of transcription, DNA-templated//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0046961//GO:0003700 proton-transporting ATPase activity, rotational mechanism//transcription factor activity, sequence-specific DNA binding GO:0033178//GO:0005667 proton-transporting two-sector ATPase complex, catalytic domain//transcription factor complex KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.16710 BF_2 48.00 3.64 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.16714 BF_2 35.40 0.32 4932 642929233 XP_008195746.1 1025 4.5e-108 PREDICTED: claspin homolog [Tribolium castaneum]>gi|270009673|gb|EFA06121.1| hypothetical protein TcasGA2_TC008964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRB5 364 8.2e-33 Claspin homolog OS=Drosophila melanogaster GN=CG32251 PE=1 SV=1 PF07827 KNTase C-terminal domain GO:0046677 response to antibiotic GO:0016779 nucleotidyltransferase activity -- -- KOG4156 Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response Cluster-8309.16716 BF_2 1.00 6.73 244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16719 BF_2 36.00 2.10 1003 462269699 AGH24360.1 591 1.9e-58 NADH dehydrogenase subunit 9 (mitochondrion) [Reclinomonas americana ATCC 50283] 156764904 AK288289.1 955 0 Oryza sativa Japonica Group cDNA, clone: J090019C07, full insert sequence K03936 NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03936 Q35322 1042 4.0e-112 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3 OS=Oryza sativa subsp. japonica GN=NAD9 PE=2 SV=2 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit GO:0006744//GO:0006120//GO:0006814//GO:0055114//GO:0015992 ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG1713 NADH-ubiquinone oxidoreductase, NDUFS3/30 kDa subunit Cluster-8309.16727 BF_2 29.21 2.96 700 642937130 XP_008198705.1 159 1.7e-08 PREDICTED: short neuropeptide F-like [Tribolium castaneum]>gi|270001316|gb|EEZ97763.1| short neuropeptide F [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16729 BF_2 5.00 0.46 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16731 BF_2 52.24 1.52 1725 91087311 XP_975575.1 1011 6.6e-107 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.5e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.16733 BF_2 116.61 3.04 1892 91089225 XP_968001.1 340 4.6e-29 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 221 1.2e-16 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 PF04999//PF02862 Cell division protein FtsL//DDHD domain GO:0051301//GO:0007049 cell division//cell cycle GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG4055 Uncharacterized conserved protein Cluster-8309.16737 BF_2 160.44 6.34 1345 91089351 XP_972899.1 1099 3.2e-117 PREDICTED: developmentally-regulated GTP-binding protein 2 [Tribolium castaneum] 820863348 XR_001112833.1 325 1.29413e-167 PREDICTED: Apis florea developmentally-regulated GTP-binding protein 2 (LOC100865446), transcript variant X4, misc_RNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 964 5.9e-103 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF01926//PF08477//PF03193//PF00176//PF00005//PF02421 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//SNF2 family N-terminal domain//ABC transporter//Ferrous iron transport protein B GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0003924//GO:0015093//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding//ATPase activity GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.16739 BF_2 436.46 3.91 4955 769848297 XP_011635512.1 1496 1.1e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.6e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF02421//PF03006//PF03193//PF00176//PF01926 Ferrous iron transport protein B//Haemolysin-III related//Protein of unknown function, DUF258//SNF2 family N-terminal domain//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0003924//GO:0015093//GO:0005524//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.16740 BF_2 30.89 0.52 2779 642924318 XP_008194246.1 711 6.5e-72 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 264 1.8e-21 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 -- -- GO:0006820//GO:0006821 anion transport//chloride transport GO:0005254 chloride channel activity GO:0034707 chloride channel complex -- -- Cluster-8309.16749 BF_2 38.00 3.32 766 722490332 YP_009107390.1 564 2.0e-55 cytochrome c oxidase subunit III (mitochondrion) [Ibacus ciliatus]>gi|699127476|gb|AIU40934.1| cytochrome c oxidase subunit III (mitochondrion) [Ibacus ciliatus] 726965594 KM576860.1 174 6.30654e-84 Glyphodes pyloalis mitochondrion, complete genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 B0FWD1 526 2.1e-52 Cytochrome c oxidase subunit 3 OS=Aedes aegypti GN=mt:CoIII PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-8309.16751 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07034 Origin recognition complex (ORC) subunit 3 N-terminus GO:0006260 DNA replication GO:0003677 DNA binding GO:0005664 nuclear origin of replication recognition complex -- -- Cluster-8309.16753 BF_2 7.14 0.32 1226 270010294 EFA06742.1 1642 3.2e-180 hypothetical protein TcasGA2_TC009676 [Tribolium castaneum] 642928000 XM_008197257.1 291 9.35652e-149 PREDICTED: Tribolium castaneum neurexin-1 (LOC663759), mRNA -- -- -- -- D0PRN3 511 1.8e-50 Neurexin-3 OS=Gallus gallus PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.16756 BF_2 50.54 3.60 875 91076134 XP_970027.1 632 2.9e-63 PREDICTED: uncharacterized protein LOC658556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16760 BF_2 465.00 27.40 997 282721150 NP_001164240.1 716 6.1e-73 serine protease P38 precursor [Tribolium castaneum]>gi|270004827|gb|EFA01275.1| serine protease P38 [Tribolium castaneum] -- -- -- -- -- K01319 CTSG cathepsin G http://www.genome.jp/dbget-bin/www_bget?ko:K01319 Q00871 476 1.7e-46 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.16761 BF_2 11.11 0.57 1105 478251163 ENN71639.1 1553 5.9e-170 hypothetical protein YQE_11737, partial [Dendroctonus ponderosae]>gi|546685824|gb|ERL95267.1| hypothetical protein D910_12533 [Dendroctonus ponderosae] 170035024 XM_001845320.1 154 1.21062e-72 Culex quinquefasciatus suppressor of forked, mRNA K14408 CSTF3, RNA14 cleavage stimulation factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14408 P25991 1198 3.6e-130 Protein suppressor of forked OS=Drosophila melanogaster GN=su(f) PE=1 SV=2 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14 Cluster-8309.16765 BF_2 203.00 13.21 930 91081497 XP_974526.1 964 1.0e-101 PREDICTED: trafficking protein particle complex subunit 4 [Tribolium castaneum]>gi|270005142|gb|EFA01590.1| hypothetical protein TcasGA2_TC007153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2TBL9 709 1.5e-73 Trafficking protein particle complex subunit 4 OS=Bos taurus GN=TRAPPC4 PE=2 SV=1 PF04099//PF04628//PF00595 Sybindin-like family//Sedlin, N-terminal conserved region//PDZ domain (Also known as DHR or GLGF) GO:0006888 ER to Golgi vesicle-mediated transport GO:0005515 protein binding GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3369 Transport protein particle (TRAPP) complex subunit Cluster-8309.16768 BF_2 136.96 5.62 1306 270008323 EFA04771.1 688 1.4e-69 hypothetical protein TcasGA2_TC030678 [Tribolium castaneum] -- -- -- -- -- K03012 RPB4, POLR2D DNA-directed RNA polymerase II subunit RPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K03012 Q9VEA5 561 3.1e-56 DNA-directed RNA polymerase II 16 kDa polypeptide OS=Drosophila melanogaster GN=Rpb4 PE=2 SV=5 PF03850//PF04958//PF03874 Transcription factor Tfb4//Arginine N-succinyltransferase beta subunit//RNA polymerase Rpb4 GO:0006527//GO:0006144//GO:0042967//GO:0006560//GO:0006351//GO:0006289//GO:0006355//GO:0006206 arginine catabolic process//purine nucleobase metabolic process//acyl-carrier-protein biosynthetic process//proline metabolic process//transcription, DNA-templated//nucleotide-excision repair//regulation of transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0008791 DNA-directed RNA polymerase activity//arginine N-succinyltransferase activity GO:0005730//GO:0000439 nucleolus//core TFIIH complex KOG2351 RNA polymerase II, fourth largest subunit Cluster-8309.16772 BF_2 20.00 4.43 476 831278612 XP_012670242.1 560 3.6e-55 PREDICTED: 40S ribosomal protein S17 [Clupea harengus] 545175896 XM_001502832.3 184 1.05402e-89 PREDICTED: Equus caballus 40S ribosomal protein S17-like (LOC100065786), mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q6QAP7 556 4.3e-56 40S ribosomal protein S17 OS=Sus scrofa GN=RPS17 PE=1 SV=3 PF00833 Ribosomal S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0187 40S ribosomal protein S17 Cluster-8309.16773 BF_2 187.59 1.70 4906 189237952 XP_001813626.1 2224 4.1e-247 PREDICTED: methyltransferase-like protein 13 [Tribolium castaneum]>gi|270008036|gb|EFA04484.1| hypothetical protein TcasGA2_TC014789 [Tribolium castaneum] 332372815 BT126586.1 196 2.47061e-95 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q9VIK9 1575 3.1e-173 Methyltransferase-like protein 13 OS=Drosophila melanogaster GN=CG2614 PE=2 SV=1 PF00025//PF08477//PF02390//PF01926//PF00503//PF07516//PF05175//PF05724//PF08241//PF00484//PF01209//PF10662//PF00071//PF04670//PF03193//PF00005 ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Putative methyltransferase//50S ribosome-binding GTPase//G-protein alpha subunit//SecA Wing and Scaffold domain//Methyltransferase small domain//Thiopurine S-methyltransferase (TPMT)//Methyltransferase domain//Carbonic anhydrase//ubiE/COQ5 methyltransferase family//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//Protein of unknown function, DUF258//ABC transporter GO:0008033//GO:0006730//GO:0007186//GO:0017038//GO:0007165//GO:0006400//GO:0032259//GO:0007264//GO:0006807//GO:0009451//GO:0006576//GO:0008152 tRNA processing//one-carbon metabolic process//G-protein coupled receptor signaling pathway//protein import//signal transduction//tRNA modification//methylation//small GTPase mediated signal transduction//nitrogen compound metabolic process//RNA modification//cellular biogenic amine metabolic process//metabolic process GO:0016887//GO:0019001//GO:0008270//GO:0008168//GO:0003924//GO:0031683//GO:0005524//GO:0008176//GO:0004871//GO:0005525//GO:0004089//GO:0008757 ATPase activity//guanyl nucleotide binding//zinc ion binding//methyltransferase activity//GTPase activity//G-protein beta/gamma-subunit complex binding//ATP binding//tRNA (guanine-N7-)-methyltransferase activity//signal transducer activity//GTP binding//carbonate dehydratase activity//S-adenosylmethionine-dependent methyltransferase activity GO:0016020 membrane KOG3886 GTP-binding protein Cluster-8309.16774 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16775 BF_2 30.02 0.40 3462 478250209 ENN70712.1 1682 2.1e-184 hypothetical protein YQE_12657, partial [Dendroctonus ponderosae]>gi|546683975|gb|ERL93709.1| hypothetical protein D910_10996 [Dendroctonus ponderosae] -- -- -- -- -- K14807 DDX51, DBP6 ATP-dependent RNA helicase DDX51/DBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K14807 P26802 930 1.3e-98 Probable ATP-dependent RNA helicase Dbp73D OS=Drosophila melanogaster GN=Dbp73D PE=2 SV=3 PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane KOG0350 DEAD-box ATP-dependent RNA helicase Cluster-8309.16778 BF_2 166.75 2.15 3534 91087237 XP_975509.1 1259 2.4e-135 PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|642929695|ref|XP_008195939.1| PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|270010578|gb|EFA07026.1| hypothetical protein TcasGA2_TC009997 [Tribolium castaneum] 827564585 CP011663.1 41 2.58893e-09 Clostridium sporogenes strain DSM 795, complete genome K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 1035 9.1e-111 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF00490//PF16834 Delta-aminolevulinic acid dehydratase//Shu complex component Csm2, DNA-binding GO:0015994//GO:0033014//GO:0000725 chlorophyll metabolic process//tetrapyrrole biosynthetic process//recombinational repair GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding GO:0005634//GO:0097196 nucleus//Shu complex KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.16779 BF_2 429.06 13.71 1596 642926052 XP_970129.2 648 7.5e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 207 4.2e-15 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16783 BF_2 19.29 0.58 1686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16784 BF_2 54.99 1.60 1726 91083583 XP_968366.1 1959 7.8e-217 PREDICTED: adenosylhomocysteinase [Tribolium castaneum]>gi|270007826|gb|EFA04274.1| hypothetical protein TcasGA2_TC014564 [Tribolium castaneum] 564237617 XM_006275631.1 132 3.24309e-60 PREDICTED: Alligator mississippiensis adenosylhomocysteinase A-like (LOC102571289), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 O76757 1818 7.2e-202 Adenosylhomocysteinase OS=Anopheles gambiae GN=Ahcy13 PE=2 SV=2 PF00208//PF00148//PF05221//PF02254//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Nitrogenase component 1 type Oxidoreductase//S-adenosyl-L-homocysteine hydrolase//TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006730//GO:0055114//GO:0006555//GO:0006520//GO:0006813 one-carbon metabolic process//oxidation-reduction process//methionine metabolic process//cellular amino acid metabolic process//potassium ion transport GO:0000166//GO:0004013//GO:0051287//GO:0016491 nucleotide binding//adenosylhomocysteinase activity//NAD binding//oxidoreductase activity -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.16785 BF_2 13.01 0.39 1676 91083583 XP_968366.1 1923 1.1e-212 PREDICTED: adenosylhomocysteinase [Tribolium castaneum]>gi|270007826|gb|EFA04274.1| hypothetical protein TcasGA2_TC014564 [Tribolium castaneum] 564237617 XM_006275631.1 131 1.13193e-59 PREDICTED: Alligator mississippiensis adenosylhomocysteinase A-like (LOC102571289), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 O76757 1789 1.6e-198 Adenosylhomocysteinase OS=Anopheles gambiae GN=Ahcy13 PE=2 SV=2 PF05221//PF00208//PF00148//PF02826//PF02254 S-adenosyl-L-homocysteine hydrolase//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Nitrogenase component 1 type Oxidoreductase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//TrkA-N domain GO:0006730//GO:0006520//GO:0006555//GO:0055114//GO:0006813 one-carbon metabolic process//cellular amino acid metabolic process//methionine metabolic process//oxidation-reduction process//potassium ion transport GO:0000166//GO:0016491//GO:0004013//GO:0051287 nucleotide binding//oxidoreductase activity//adenosylhomocysteinase activity//NAD binding -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.16788 BF_2 114.00 8.46 851 478251069 ENN71548.1 639 4.4e-64 hypothetical protein YQE_11776, partial [Dendroctonus ponderosae]>gi|546677072|gb|ERL87981.1| hypothetical protein D910_05369 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VY86 518 2.0e-51 TM2 domain-containing protein CG11103 OS=Drosophila melanogaster GN=CG11103 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4272 Predicted GTP-binding protein Cluster-8309.16790 BF_2 427.16 8.27 2447 270010175 EFA06623.1 2604 1.8e-291 hypothetical protein TcasGA2_TC009541 [Tribolium castaneum] 687022647 LM525561.1 43 1.38045e-10 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_scaffold0000006 K10481 BTBD9 BTB/POZ domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10481 A4IFG2 1654 1.1e-182 BTB/POZ domain-containing protein 9 OS=Bos taurus GN=BTBD9 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.16795 BF_2 133.60 1.31 4562 820239016 BAR72977.1 1879 3.9e-207 cytochrome P450 15A1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q6R7M4 1354 1.2e-147 Methyl farnesoate epoxidase OS=Diploptera punctata GN=CYP15A1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.16796 BF_2 50.58 1.03 2346 531443692 AGT57832.1 1428 4.0e-155 cytochrome P450 305a1, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9VW43 1035 6.1e-111 Probable cytochrome P450 305a1 OS=Drosophila melanogaster GN=Cyp305a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.16802 BF_2 1.00 0.60 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16803 BF_2 4.00 1.63 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06027//PF01363//PF00892//PF02744 Solute carrier family 35//FYVE zinc finger//EamA-like transporter family//Galactose-1-phosphate uridyl transferase, C-terminal domain GO:0009117//GO:0006810//GO:0006012 nucleotide metabolic process//transport//galactose metabolic process GO:0046872//GO:0008108 metal ion binding//UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.16804 BF_2 27.01 1.55 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16805 BF_2 8.84 0.36 1302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0006090//GO:0071436//GO:0006525//GO:0006560 sodium ion transport//pyruvate metabolic process//sodium ion export//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.16808 BF_2 35.00 0.78 2170 546672570 ERL84380.1 1767 1.8e-194 hypothetical protein D910_01810 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q99046 398 4.1e-37 Laccase-2 OS=Trametes villosa GN=LCC2 PE=3 SV=1 PF07731//PF00394//PF07732 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- -- -- Cluster-8309.16809 BF_2 4.00 0.45 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16819 BF_2 493.64 2.63 8144 642913946 XP_008201225.1 10151 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2900 0.0e+00 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF00025//PF13855//PF13606//PF07714//PF00069//PF08477//PF00071//PF07645 ADP-ribosylation factor family//Leucine rich repeat//Ankyrin repeat//Protein tyrosine kinase//Protein kinase domain//Ras of Complex, Roc, domain of DAPkinase//Ras family//Calcium-binding EGF domain GO:0007264//GO:0006468 small GTPase mediated signal transduction//protein phosphorylation GO:0005525//GO:0005524//GO:0005509//GO:0005515//GO:0004672 GTP binding//ATP binding//calcium ion binding//protein binding//protein kinase activity -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.16820 BF_2 3.00 0.42 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16823 BF_2 30.16 0.94 1631 478262315 ENN81032.1 964 1.7e-101 hypothetical protein YQE_02551, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P10076 434 2.1e-41 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF07776//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.16824 BF_2 4.00 0.41 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16826 BF_2 1.00 3.32 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16828 BF_2 7.65 2.71 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16829 BF_2 128.06 2.95 2103 642936055 XP_008198283.1 1363 1.2e-147 PREDICTED: fringe glycosyltransferase [Tribolium castaneum]>gi|270013211|gb|EFA09659.1| hypothetical protein TcasGA2_TC011785 [Tribolium castaneum] 462318872 APGK01044259.1 47 7.07303e-13 Dendroctonus ponderosae Seq01044269, whole genome shotgun sequence K05948 FNG fringe http://www.genome.jp/dbget-bin/www_bget?ko:K05948 Q24342 1053 4.4e-113 Fringe glycosyltransferase OS=Drosophila melanogaster GN=fng PE=1 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.16836 BF_2 65.73 1.52 2092 268370072 NP_001161228.1 1375 4.9e-149 phosphatidylinositol glycan, class B [Tribolium castaneum] -- -- -- -- -- K05286 PIGB phosphatidylinositol glycan, class B http://www.genome.jp/dbget-bin/www_bget?ko:K05286 Q9VZM5 1081 2.5e-116 GPI mannosyltransferase 3 OS=Drosophila melanogaster GN=CG12006 PE=2 SV=2 PF03901 Alg9-like mannosyltransferase family -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis Cluster-8309.16840 BF_2 18.85 0.36 2479 642927181 XP_008195169.1 2351 3.9e-262 PREDICTED: synaptic vesicle glycoprotein 2B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q7L1I2 482 8.5e-47 Synaptic vesicle glycoprotein 2B OS=Homo sapiens GN=SV2B PE=1 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.16841 BF_2 5.00 0.43 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16843 BF_2 17.00 0.38 2167 861601583 KMQ83835.1 535 1.3e-51 hypothetical protein RF55_19003 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16844 BF_2 79.48 1.54 2441 189239328 XP_973240.2 2486 8.6e-278 PREDICTED: ribosome-releasing factor 2, mitochondrial [Tribolium castaneum] 242013425 XM_002427363.1 101 7.88708e-43 Pediculus humanus corporis elongation factor G 2, putative, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 Q9VCX4 1778 4.4e-197 Ribosome-releasing factor 2, mitochondrial OS=Drosophila melanogaster GN=EF-G2 PE=2 SV=3 PF03144//PF01926//PF04548 Elongation factor Tu domain 2//50S ribosome-binding GTPase//AIG1 family -- -- GO:0005525 GTP binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.16845 BF_2 37.96 0.61 2881 270001480 EEZ97927.1 553 1.4e-53 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H5L6 198 8.5e-14 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.16847 BF_2 55.89 0.79 3234 91076346 XP_966525.1 1658 1.2e-181 PREDICTED: leucine zipper putative tumor suppressor 2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U4W1 429 1.6e-40 Leucine zipper putative tumor suppressor 2 homolog OS=Xenopus laevis GN=lzts2 PE=2 SV=1 PF10288//PF01008//PF00769 Cytoplasmic tRNA 2-thiolation protein 2//Initiation factor 2 subunit family//Ezrin/radixin/moesin family GO:0034227//GO:0044237//GO:0002098 tRNA thio-modification//cellular metabolic process//tRNA wobble uridine modification GO:0008092//GO:0000049 cytoskeletal protein binding//tRNA binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm -- -- Cluster-8309.16853 BF_2 50.89 0.48 4726 642935985 XP_008198257.1 561 2.7e-54 PREDICTED: uncharacterized protein LOC103314318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IG66 285 1.1e-23 Transmembrane protein 201 OS=Danio rerio GN=tmem201 PE=2 SV=1 PF06703//PF01680 Microsomal signal peptidase 25 kDa subunit (SPC25)//SOR/SNZ family GO:0042819//GO:0006465//GO:0042823 vitamin B6 biosynthetic process//signal peptide processing//pyridoxal phosphate biosynthetic process GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane KOG4623 Uncharacterized conserved protein Cluster-8309.16856 BF_2 206.00 14.41 885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16858 BF_2 32.13 1.19 1416 642912496 XP_008200890.1 409 3.5e-37 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.16862 BF_2 15.00 2.83 509 724892375 XP_010375260.1 296 1.6e-24 PREDICTED: RAC-alpha serine/threonine-protein kinase-like [Rhinopithecus roxellana] 15282126 AL590327.3 509 0 Human chromosome 14 DNA sequence Partial sequence from BAC C-2507D9 of library CalTech-D from chromosome 14 of Homo sapiens (Human), complete sequence K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 P31749 256 2.8e-21 RAC-alpha serine/threonine-protein kinase OS=Homo sapiens GN=AKT1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16868 BF_2 33.39 1.50 1220 478255317 ENN75543.1 159 2.9e-08 hypothetical protein YQE_07886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16873 BF_2 93.00 1.10 3808 91085531 XP_972280.1 1517 3.1e-165 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 1228 4.1e-133 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00473//PF00795 Corticotropin-releasing factor family//Carbon-nitrogen hydrolase GO:0007165//GO:0006807 signal transduction//nitrogen compound metabolic process GO:0005179//GO:0016810 hormone activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0005576 extracellular region KOG2648 Diphthamide biosynthesis protein Cluster-8309.16875 BF_2 5.00 0.40 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16879 BF_2 10.81 0.50 1194 91080689 XP_975235.1 441 5.7e-41 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [Tribolium castaneum]>gi|270006426|gb|EFA02874.1| hypothetical protein TcasGA2_TC007967 [Tribolium castaneum] 642919565 XM_970142.2 45 5.12781e-12 PREDICTED: Tribolium castaneum NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (LOC664127), mRNA K03953 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03953 -- -- -- -- -- -- GO:0044237 cellular metabolic process GO:0050662//GO:0003824//GO:0000166 coenzyme binding//catalytic activity//nucleotide binding -- -- -- -- Cluster-8309.1688 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16882 BF_2 16.00 1.05 925 357603721 EHJ63895.1 164 5.8e-09 hypothetical protein KGM_21858 [Danaus plexippus] 462372117 APGK01025209.1 142 4.71911e-66 Dendroctonus ponderosae Seq01025219, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16886 BF_2 265.28 13.64 1101 170028910 XP_001842337.1 828 6.9e-86 cathepsin L [Culex quinquefasciatus]>gi|167879387|gb|EDS42770.1| cathepsin L [Culex quinquefasciatus] -- -- -- -- -- K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 767 3.4e-80 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF08127//PF03051//PF00112 Peptidase family C1 propeptide//Peptidase C1-like family//Papain family cysteine protease GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197//GO:0008233 cysteine-type peptidase activity//cysteine-type endopeptidase activity//peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.16887 BF_2 2.00 2.86 300 -- -- -- -- -- 60649821 AJ829764.1 131 1.84288e-60 Otiorhynchus sulcatus partial cbh1 gene for cellulose 1,4-beta-cellobiosidase, six exons -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16889 BF_2 69.01 1.12 2869 642924825 XP_967668.2 863 1.6e-89 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 458 6.0e-44 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16892 BF_2 13.00 3.77 431 332375510 AEE62896.1 233 2.7e-17 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01310 CTRB chymotrypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01310 P00771 181 1.2e-12 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.16895 BF_2 1.00 1.32 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16898 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16899 BF_2 149.00 4.61 1640 478249977 ENN70484.1 828 1.0e-85 hypothetical protein YQE_12987, partial [Dendroctonus ponderosae]>gi|546679646|gb|ERL90077.1| hypothetical protein D910_07432 [Dendroctonus ponderosae] -- -- -- -- -- K06201 cutC copper homeostasis protein http://www.genome.jp/dbget-bin/www_bget?ko:K06201 Q9NTM9 492 3.9e-48 Copper homeostasis protein cutC homolog OS=Homo sapiens GN=CUTC PE=1 SV=1 PF00121//PF02581//PF03932//PF01081 Triosephosphate isomerase//Thiamine monophosphate synthase/TENI//CutC family//KDPG and KHG aldolase GO:0009228//GO:0006020//GO:0006096//GO:0008152//GO:0055070//GO:0006000//GO:0046486//GO:0006013//GO:0006094//GO:0015976 thiamine biosynthetic process//inositol metabolic process//glycolytic process//metabolic process//copper ion homeostasis//fructose metabolic process//glycerolipid metabolic process//mannose metabolic process//gluconeogenesis//carbon utilization GO:0004789//GO:0005507//GO:0004807//GO:0016829 thiamine-phosphate diphosphorylase activity//copper ion binding//triose-phosphate isomerase activity//lyase activity -- -- KOG4013 Predicted Cu2+ homeostasis protein CutC Cluster-8309.16900 BF_2 94.33 0.97 4367 642911114 XP_008200584.1 3555 0.0e+00 PREDICTED: tyrosine-protein phosphatase 99A [Tribolium castaneum] 195445683 XM_002070402.1 103 1.09718e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2408 7.0e-270 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00782//PF00041//PF00102 Dual specificity phosphatase, catalytic domain//Fibronectin type III domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- -- -- Cluster-8309.16909 BF_2 35.65 0.67 2499 826414788 XP_012522091.1 1086 1.9e-115 PREDICTED: calpain-A isoform X2 [Monomorium pharaonis] 805805104 XM_003705388.2 60 5.00075e-20 PREDICTED: Megachile rotundata calpain-A (LOC100882339), transcript variant X9, mRNA K03853 CAPN2 calpain-2 http://www.genome.jp/dbget-bin/www_bget?ko:K03853 Q11002 1030 2.4e-110 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF13499//PF13833//PF13405//PF00036//PF12763//PF13202//PF00648 EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand//Calpain family cysteine protease GO:0006508 proteolysis GO:0005515//GO:0004198//GO:0005509 protein binding//calcium-dependent cysteine-type endopeptidase activity//calcium ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.16913 BF_2 63.29 0.52 5409 270004664 EFA01112.1 1792 5.6e-197 hypothetical protein TcasGA2_TC010324 [Tribolium castaneum] 752889233 XM_011264255.1 203 3.50117e-99 PREDICTED: Camponotus floridanus probable ATP-dependent RNA helicase DDX17 (LOC105255133), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1426 6.4e-156 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF04851//PF00270//PF00004 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA) -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.16922 BF_2 18.16 0.39 2260 642937110 XP_008198695.1 382 7.4e-34 PREDICTED: major facilitator superfamily domain-containing protein 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0T7 163 7.6e-10 Major facilitator superfamily domain-containing protein 9 OS=Mus musculus GN=Mfsd9 PE=2 SV=1 PF07415//PF07690//PF00083//PF01306 Gammaherpesvirus latent membrane protein (LMP2) protein//Major Facilitator Superfamily//Sugar (and other) transporter//LacY proton/sugar symporter GO:0019042//GO:0055085//GO:0006810 viral latency//transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021//GO:0033644 membrane//integral component of membrane//host cell membrane -- -- Cluster-8309.16924 BF_2 79.03 2.31 1720 642937110 XP_008198695.1 493 7.6e-47 PREDICTED: major facilitator superfamily domain-containing protein 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBP5 144 9.2e-08 Major facilitator superfamily domain-containing protein 9 OS=Homo sapiens GN=MFSD9 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.16925 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16926 BF_2 602.99 10.99 2582 189239136 XP_971870.2 1153 3.4e-123 PREDICTED: abhydrolase domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- K13698 ABHD4 abhydrolase domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13698 Q8VD66 771 2.7e-80 Abhydrolase domain-containing protein 4 OS=Mus musculus GN=Abhd4 PE=2 SV=1 PF00975//PF03403//PF07859//PF01764 Thioesterase domain//Platelet-activating factor acetylhydrolase, isoform II//alpha/beta hydrolase fold//Lipase (class 3) GO:0016042//GO:0009058//GO:0046486//GO:0008152//GO:0006629 lipid catabolic process//biosynthetic process//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0003847//GO:0016787//GO:0016788 1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.16928 BF_2 76.46 1.20 2963 189236145 XP_974763.2 1411 4.7e-153 PREDICTED: diphthine--ammonia ligase [Tribolium castaneum]>gi|270005602|gb|EFA02050.1| hypothetical protein TcasGA2_TC007678 [Tribolium castaneum] -- -- -- -- -- K06927 DPH6 diphthine-ammonia ligase http://www.genome.jp/dbget-bin/www_bget?ko:K06927 Q2HJF5 794 6.7e-83 Diphthine--ammonia ligase OS=Bos taurus GN=DPH6 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2316 Predicted ATPase (PP-loop superfamily) Cluster-8309.16936 BF_2 97.48 3.21 1557 642915218 XP_008190526.1 1696 2.2e-186 PREDICTED: UDP-glucose 6-dehydrogenase isoform X1 [Tribolium castaneum] 332376888 BT128627.1 168 2.83753e-80 Dendroctonus ponderosae clone DPO012_D10 unknown mRNA K00012 UGDH, ugd UDPglucose 6-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00012 O02373 1573 1.7e-173 UDP-glucose 6-dehydrogenase OS=Drosophila melanogaster GN=sgl PE=1 SV=1 PF00984//PF03446//PF03721//PF03720 UDP-glucose/GDP-mannose dehydrogenase family, central domain//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain GO:0006098//GO:0019521//GO:0055114 pentose-phosphate shunt//D-gluconate metabolic process//oxidation-reduction process GO:0004616//GO:0016616//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG2666 UDP-glucose/GDP-mannose dehydrogenase Cluster-8309.16937 BF_2 208.00 5.49 1872 642927799 XP_008195409.1 168 4.0e-09 PREDICTED: uncharacterized protein LOC103313581 [Tribolium castaneum]>gi|270009878|gb|EFA06326.1| hypothetical protein TcasGA2_TC009197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16939 BF_2 2.88 0.44 562 189233768 XP_001814337.1 267 4.0e-21 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 221 3.5e-17 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.16943 BF_2 7.00 0.90 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16946 BF_2 64.61 2.77 1263 91088333 XP_970609.1 956 1.1e-100 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 575 7.1e-58 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF04851//PF07690 Type III restriction enzyme, res subunit//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0005524//GO:0003677//GO:0016787 ATP binding//DNA binding//hydrolase activity GO:0016021 integral component of membrane -- -- Cluster-8309.16948 BF_2 10.00 1.25 622 470241879 XP_004354573.1 270 2.0e-21 NAD-dependent epimerase/dehydratase family protein [Dictyostelium fasciculatum]>gi|328867808|gb|EGG16189.1| NAD-dependent epimerase/dehydratase family protein [Dictyostelium fasciculatum] 385718964 JQ070804.1 308 1.63858e-158 Paeonia lactiflora dihydroflavonol 4-reductase (DFR) mRNA, complete cds -- -- -- -- P51110 1006 3.7e-108 Dihydroflavonol-4-reductase OS=Vitis vinifera GN=DFR PE=1 SV=1 PF01370//PF01073 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0003824//GO:0050662//GO:0003854 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.1695 BF_2 5.14 0.59 653 270007495 EFA03943.1 376 1.1e-33 hypothetical protein TcasGA2_TC014087 [Tribolium castaneum] -- -- -- -- -- K08834 MYO3, DFNB30 myosin III http://www.genome.jp/dbget-bin/www_bget?ko:K08834 P10676 263 5.5e-22 Neither inactivation nor afterpotential protein C OS=Drosophila melanogaster GN=ninaC PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.16951 BF_2 115.00 4.30 1406 676446104 XP_009050970.1 147 8.2e-07 hypothetical protein LOTGIDRAFT_159061 [Lottia gigantea]>gi|556109613|gb|ESO98265.1| hypothetical protein LOTGIDRAFT_159061 [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14659 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.16954 BF_2 16.00 1.26 818 307165921 EFN60256.1 345 5.2e-30 hypothetical protein EAG_00437, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16956 BF_2 179.58 2.41 3410 478252068 ENN72499.1 334 4.1e-28 hypothetical protein YQE_10840, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5UPA0 134 2.6e-06 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16957 BF_2 30.77 0.63 2319 817199200 XP_012275275.1 876 4.0e-91 PREDICTED: 4-hydroxyphenylpyruvate dioxygenase [Orussus abietinus] -- -- -- -- -- K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 P32755 766 9.3e-80 4-hydroxyphenylpyruvate dioxygenase OS=Rattus norvegicus GN=Hpd PE=1 SV=3 PF00631//PF08573//PF02050 GGL domain//DNA repair protein endonuclease SAE2/CtIP C-terminus//Flagellar FliJ protein GO:0006935//GO:0007165//GO:0006281//GO:0071973//GO:0000077//GO:0007186//GO:0006308 chemotaxis//signal transduction//DNA repair//bacterial-type flagellum-dependent cell motility//DNA damage checkpoint//G-protein coupled receptor signaling pathway//DNA catabolic process GO:0004871//GO:0003774//GO:0000014 signal transducer activity//motor activity//single-stranded DNA endodeoxyribonuclease activity GO:0005834//GO:0016020//GO:0009288 heterotrimeric G-protein complex//membrane//bacterial-type flagellum KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.16962 BF_2 15.52 0.51 1551 270003816 EFA00264.1 206 1.3e-13 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF16622//PF13465//PF02701//PF00096 BED zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Dof domain, zinc finger//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.16965 BF_2 2.00 1.02 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16967 BF_2 1.00 2.01 285 641662887 XP_008182425.1 275 2.4e-22 PREDICTED: zinc finger BED domain-containing protein 6-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16970 BF_2 84.00 11.64 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16971 BF_2 2.00 2.48 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16973 BF_2 28.74 1.25 1251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16974 BF_2 11.69 0.74 947 817206159 XP_012279008.1 416 3.6e-38 PREDICTED: nuclear cap-binding protein subunit 2 [Orussus abietinus] 572310349 XM_006620871.1 127 1.05416e-57 PREDICTED: Apis dorsata nuclear cap-binding protein subunit 2-like (LOC102673777), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 392 8.9e-37 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.16975 BF_2 93.27 2.43 1893 436466 CAA82360.1 633 4.9e-63 putative transposase [Drosophila hydei]>gi|743805|prf||2013359A transposase -- -- -- -- -- -- -- -- -- Q04202 284 5.9e-24 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 PF03184//PF04545//PF06056//PF13463//PF00292//PF00440//PF08281//PF08541//PF04218//PF01498 DDE superfamily endonuclease//Sigma-70, region 4//Putative ATPase subunit of terminase (gpP-like)//Winged helix DNA-binding domain//'Paired box' domain//Bacterial regulatory proteins, tetR family//Sigma-70, region 4//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//CENP-B N-terminal DNA-binding domain//Transposase GO:0006313//GO:0006355//GO:0008610//GO:0019069//GO:0006352//GO:0015074 transposition, DNA-mediated//regulation of transcription, DNA-templated//lipid biosynthetic process//viral capsid assembly//DNA-templated transcription, initiation//DNA integration GO:0005524//GO:0003677//GO:0016987//GO:0003676//GO:0003700//GO:0016747 ATP binding//DNA binding//sigma factor activity//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005667 transcription factor complex -- -- Cluster-8309.16979 BF_2 6.00 0.38 951 270014928 EFA11376.1 331 2.6e-28 hypothetical protein TcasGA2_TC011535 [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 P97823 226 1.6e-17 Acyl-protein thioesterase 1 OS=Mus musculus GN=Lypla1 PE=1 SV=1 PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- KOG2112 Lysophospholipase Cluster-8309.16981 BF_2 315.86 3.01 4674 642933180 XP_008197291.1 1842 7.8e-203 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X3 [Tribolium castaneum] 430763429 JQ753065.1 49 1.2259e-13 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 P48543 896 1.6e-94 G protein-activated inward rectifier potassium channel 3 OS=Mus musculus GN=Kcnj9 PE=2 SV=2 PF00520//PF01007//PF10716 Ion transport protein//Inward rectifier potassium channel//NADH dehydrogenase transmembrane subunit GO:0006118//GO:0006811//GO:0055114//GO:0055085//GO:0006813 obsolete electron transport//ion transport//oxidation-reduction process//transmembrane transport//potassium ion transport GO:0005216//GO:0016655//GO:0005242 ion channel activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//inward rectifier potassium channel activity GO:0016020//GO:0008076//GO:0016021 membrane//voltage-gated potassium channel complex//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.16982 BF_2 11.00 0.38 1502 642917814 XP_008191296.1 184 4.5e-11 PREDICTED: ankyrin-3-like isoform X4 [Tribolium castaneum] 642917815 XM_008193075.1 75 1.36575e-28 PREDICTED: Tribolium castaneum ankyrin-3-like (LOC656174), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16983 BF_2 134.43 18.75 587 471180443 AGI05172.1 382 1.9e-34 chemosensory protein 2 [Dendroctonus ponderosae]>gi|478257979|gb|ENN78117.1| hypothetical protein YQE_05271, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 270 7.7e-23 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.16986 BF_2 5.00 0.43 774 546686991 ERL95939.1 156 4.1e-08 hypothetical protein D910_00636, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16987 BF_2 14.34 0.66 1190 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16989 BF_2 111.32 5.28 1169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16990 BF_2 17.17 0.37 2231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16991 BF_2 12.37 0.74 991 642924780 XP_975331.2 291 1.2e-23 PREDICTED: protein FAM122A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.16999 BF_2 34.58 0.38 4099 642926092 XP_008194763.1 1772 8.9e-195 PREDICTED: MAP/microtubule affinity-regulating kinase 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REX1 141 4.9e-07 Serine/threonine-protein kinase SIK2 OS=Pongo abelii GN=SIK2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17005 BF_2 83.20 0.57 6400 270015831 EFA12279.1 835 6.2e-86 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05992 SbmA/BacA-like family GO:0006810 transport GO:0005215 transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.17006 BF_2 87.00 8.90 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17007 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17012 BF_2 3.00 3.20 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17013 BF_2 214.81 5.89 1812 571330974 AHF27419.1 1465 1.6e-159 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q17NV8 752 3.1e-78 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF01229//PF07690//PF00083 Glycosyl hydrolases family 39//Major Facilitator Superfamily//Sugar (and other) transporter GO:0005975//GO:0055085 carbohydrate metabolic process//transmembrane transport GO:0004553//GO:0022857 hydrolase activity, hydrolyzing O-glycosyl compounds//transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.17014 BF_2 325.21 5.66 2692 642933768 XP_008197204.1 3022 0.0e+00 PREDICTED: WD repeat-containing protein mio-B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q802U2 1629 9.2e-180 WD repeat-containing protein mio OS=Danio rerio GN=mios PE=2 SV=1 PF00400//PF13639 WD domain, G-beta repeat//Ring finger domain -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1008 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.17015 BF_2 134.00 3.40 1938 546675918 ERL87018.1 756 2.7e-77 hypothetical protein D910_04420 [Dendroctonus ponderosae] -- -- -- -- -- K15187 MLLT1_3, ENL, AF9 YEATS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15187 A2AM29 455 9.0e-44 Protein AF-9 OS=Mus musculus GN=Mllt3 PE=1 SV=1 PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.17018 BF_2 489.23 7.53 3005 642916609 XP_008191874.1 1145 3.3e-122 PREDICTED: m7GpppX diphosphatase [Tribolium castaneum] -- -- -- -- -- K12584 DCPS, DCS m7GpppX diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K12584 D3K0N9 719 3.4e-74 m7GpppX diphosphatase OS=Ascaris suum PE=1 SV=1 PF05652 Scavenger mRNA decapping enzyme (DcpS) N-terminal GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0016787 hydrolase activity -- -- KOG3969 Uncharacterized conserved protein Cluster-8309.17021 BF_2 247.00 18.96 832 91076396 XP_969017.1 648 3.9e-65 PREDICTED: 39S ribosomal protein L43, mitochondrial [Tribolium castaneum]>gi|642912312|ref|XP_008200645.1| PREDICTED: 39S ribosomal protein L43, mitochondrial [Tribolium castaneum]>gi|270002560|gb|EEZ99007.1| hypothetical protein TcasGA2_TC004871 [Tribolium castaneum] -- -- -- -- -- K17424 MRPL43 large subunit ribosomal protein L43 http://www.genome.jp/dbget-bin/www_bget?ko:K17424 Q99N89 262 9.3e-22 39S ribosomal protein L43, mitochondrial OS=Mus musculus GN=Mrpl43 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3445 Mitochondrial/chloroplast ribosomal protein 36a Cluster-8309.17023 BF_2 25.90 0.93 1447 827547769 XP_012546165.1 265 1.8e-20 PREDICTED: uncharacterized protein LOC101737154 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01531//PF03849 Glycosyl transferase family 11//Transcription factor Tfb2 GO:0009247//GO:0006289//GO:0005975//GO:0001575 glycolipid biosynthetic process//nucleotide-excision repair//carbohydrate metabolic process//globoside metabolic process GO:0004003//GO:0008107 ATP-dependent DNA helicase activity//galactoside 2-alpha-L-fucosyltransferase activity GO:0016020//GO:0000439//GO:0005634//GO:0005657 membrane//core TFIIH complex//nucleus//replication fork -- -- Cluster-8309.17024 BF_2 41.00 0.76 2552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17025 BF_2 257.00 6.76 1877 642936400 XP_972145.2 626 3.1e-62 PREDICTED: 23 kDa integral membrane protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XSK2 270 2.5e-22 CD63 antigen OS=Bos taurus GN=CD63 PE=2 SV=4 PF07415//PF00335 Gammaherpesvirus latent membrane protein (LMP2) protein//Tetraspanin family GO:0019042 viral latency -- -- GO:0033644//GO:0016021 host cell membrane//integral component of membrane -- -- Cluster-8309.17026 BF_2 7.38 1.75 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297 Herpesvirus latent membrane protein 1 (LMP1) GO:0019087 transformation of host cell by virus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17029 BF_2 113.61 1.47 3521 478252986 ENN73368.1 2585 4.1e-289 hypothetical protein YQE_10018, partial [Dendroctonus ponderosae] 847107195 XM_012958238.1 37 4.31609e-07 PREDICTED: Xenopus (Silurana) tropicalis piwi-like RNA-mediated gene silencing 4 (piwil4), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 Q7PLK0 1621 1.0e-178 Protein argonaute-3 OS=Drosophila melanogaster GN=AGO3 PE=1 SV=3 PF02170//PF02171 PAZ domain//Piwi domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.17033 BF_2 9.00 0.32 1471 410509310 BAM65721.1 1581 4.5e-173 myosin heavy chain type 1 [Litopenaeus vannamei] 665408331 NM_165185.3 69 2.89386e-25 Drosophila melanogaster myosin heavy chain (Mhc), transcript variant F, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1481 7.3e-163 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063//PF00612//PF01576 Myosin head (motor domain)//IQ calmodulin-binding motif//Myosin tail -- -- GO:0005515//GO:0003774//GO:0005524 protein binding//motor activity//ATP binding GO:0016459 myosin complex -- -- Cluster-8309.17037 BF_2 4.01 0.37 743 170047639 XP_001851321.1 300 7.9e-25 conserved hypothetical protein [Culex quinquefasciatus]>gi|167870002|gb|EDS33385.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 281 5.2e-24 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 -- -- -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG1365 RNA-binding protein Fusilli, contains RRM domain Cluster-8309.17040 BF_2 20.51 0.60 1708 642935405 XP_008197997.1 517 1.2e-49 PREDICTED: tumor protein p63-regulated gene 1-like protein isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0D9 197 6.5e-14 Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens GN=TPRG1L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17043 BF_2 26.00 2.01 828 700365745 XP_009927550.1 559 8.2e-55 PREDICTED: translationally-controlled tumor protein homolog, partial [Haliaeetus albicilla] 545879925 KF285442.1 810 0 Oryza sativa Japonica Group cultivar Ilpumbyeo 21 kDa protein mRNA, complete cds -- -- -- -- P35681 811 2.0e-85 Translationally-controlled tumor protein homolog OS=Oryza sativa subsp. japonica GN=TCTP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.17047 BF_2 29.00 3.40 644 295792250 ADG29129.1 631 2.8e-63 glyceraldehyde-3-phosphate dehydrogenase [Epinephelus coioides] 119434401 EF125181.1 644 0 Oryza sativa (japonica cultivar-group) clone KCS315C06 glyceralde-3-phosphate dehydrogenase mRNA, complete cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q6K5G8 907 1.2e-96 Glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic OS=Oryza sativa subsp. japonica GN=GAPC3 PE=2 SV=1 PF02800//PF01113//PF02826//PF00044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Dihydrodipicolinate reductase, N-terminus//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0009085//GO:0055114//GO:0009089 lysine biosynthetic process//oxidation-reduction process//lysine biosynthetic process via diaminopimelate GO:0016620//GO:0051287//GO:0008839 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding//4-hydroxy-tetrahydrodipicolinate reductase -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.17050 BF_2 8.00 1.21 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17052 BF_2 5.00 0.77 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17056 BF_2 7.00 0.38 1064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17062 BF_2 92.00 1.20 3507 189234499 XP_001812694.1 1439 3.1e-156 PREDICTED: vasorin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 280 3.2e-23 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.17063 BF_2 144.59 0.85 7374 642911815 XP_008200755.1 5961 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17066 BF_2 23.26 0.55 2044 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17073 BF_2 68.81 0.86 3640 91090486 XP_968848.1 739 4.8e-75 PREDICTED: GTP-binding protein Di-Ras2 [Tribolium castaneum]>gi|270013863|gb|EFA10311.1| hypothetical protein TcasGA2_TC012527 [Tribolium castaneum] 642935350 XM_963755.2 98 5.4949e-41 PREDICTED: Tribolium castaneum GTP-binding protein Di-Ras2 (LOC657287), mRNA K07841 DIRAS2 DIRAS family, GTP-binding Ras-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07841 Q95KD9 516 1.4e-50 GTP-binding protein Di-Ras2 OS=Macaca fascicularis GN=DIRAS2 PE=2 SV=1 PF01926//PF01637//PF03193//PF08477//PF00071//PF00025 50S ribosome-binding GTPase//Archaeal ATPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.17074 BF_2 63.71 1.03 2876 91090486 XP_968848.1 739 3.8e-75 PREDICTED: GTP-binding protein Di-Ras2 [Tribolium castaneum]>gi|270013863|gb|EFA10311.1| hypothetical protein TcasGA2_TC012527 [Tribolium castaneum] 642935350 XM_963755.2 98 4.33005e-41 PREDICTED: Tribolium castaneum GTP-binding protein Di-Ras2 (LOC657287), mRNA K07841 DIRAS2 DIRAS family, GTP-binding Ras-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07841 Q95KD9 516 1.1e-50 GTP-binding protein Di-Ras2 OS=Macaca fascicularis GN=DIRAS2 PE=2 SV=1 PF03193//PF08477//PF01637//PF01926//PF00025//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Archaeal ATPase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.17075 BF_2 32.00 0.54 2788 642927384 XP_008195248.1 595 1.8e-58 PREDICTED: leucine-rich repeat-containing protein 40-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17083 BF_2 3.00 1.26 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17084 BF_2 135.00 5.42 1329 642928651 XP_008199722.1 634 2.6e-63 PREDICTED: hemK methyltransferase family member 2 [Tribolium castaneum] -- -- -- -- -- K19589 N6AMT1 release factor glutamine methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19589 Q9Y5N5 411 7.8e-39 HemK methyltransferase family member 2 OS=Homo sapiens GN=N6AMT1 PE=1 SV=3 PF05175//PF08241//PF06160//PF16740//PF01624//PF08165//PF08702 Methyltransferase small domain//Methyltransferase domain//Septation ring formation regulator, EzrA//Spindle and kinetochore-associated protein 2//MutS domain I//FerA (NUC095) domain//Fibrinogen alpha/beta chain family GO:0031110//GO:0051301//GO:0007067//GO:0000090//GO:0007059//GO:0007165//GO:0051258//GO:0030168//GO:0006298//GO:0008152//GO:0000921 regulation of microtubule polymerization or depolymerization//cell division//mitotic nuclear division//mitotic anaphase//chromosome segregation//signal transduction//protein polymerization//platelet activation//mismatch repair//metabolic process//septin ring assembly GO:0030983//GO:0005102//GO:0008168//GO:0005524//GO:0008017//GO:0030674 mismatched DNA binding//receptor binding//methyltransferase activity//ATP binding//microtubule binding//protein binding, bridging GO:0005577//GO:0005876//GO:0016021//GO:0045298//GO:0005940//GO:0000940 fibrinogen complex//spindle microtubule//integral component of membrane//tubulin complex//septin ring//condensed chromosome outer kinetochore KOG3191 Predicted N6-DNA-methyltransferase Cluster-8309.17086 BF_2 138.00 6.73 1145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17087 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17093 BF_2 98.22 7.54 832 546676860 ERL87797.1 510 3.9e-49 hypothetical protein D910_05186 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6Q3F5 349 7.6e-32 SID1 transmembrane family member 1 OS=Rattus norvegicus GN=Sidt1 PE=2 SV=2 PF13965//PF07690//PF06423//PF05875 dsRNA-gated channel SID-1//Major Facilitator Superfamily//GWT1//Ceramidase GO:0006672//GO:0055085//GO:0015931//GO:0033227//GO:0006807//GO:0006506 ceramide metabolic process//transmembrane transport//nucleobase-containing compound transport//dsRNA transport//nitrogen compound metabolic process//GPI anchor biosynthetic process GO:0016746//GO:0016811//GO:0051033 transferase activity, transferring acyl groups//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//RNA transmembrane transporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.17097 BF_2 24.39 0.58 2032 209418846 ACI46638.1 1944 5.0e-215 serine proteinase [Portunus trituberculatus] 209418845 FJ360742.1 1137 0 Portunus trituberculatus strain LZW serine proteinase (SP) mRNA, complete cds K01316 PRSS7 protease, serine, 7 (enterokinase) http://www.genome.jp/dbget-bin/www_bget?ko:K01316 P21902 538 2.2e-53 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.1710 BF_2 5.00 0.55 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17100 BF_2 59.94 2.79 1187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17101 BF_2 34.06 1.02 1679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17102 BF_2 30.59 0.48 2926 642927837 XP_008195420.1 555 8.4e-54 PREDICTED: HSPB1-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q6AXL5 257 1.2e-20 HSPB1-associated protein 1 homolog OS=Danio rerio GN=hspbap1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.17103 BF_2 29.03 0.51 2650 91086211 XP_971977.1 943 7.7e-99 PREDICTED: HSPB1-associated protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q96EW2 492 6.3e-48 HSPB1-associated protein 1 OS=Homo sapiens GN=HSPBAP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.17111 BF_2 7.00 0.78 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17112 BF_2 67.06 1.89 1775 91088521 XP_971980.1 407 7.4e-37 PREDICTED: protein drumstick isoform X2 [Tribolium castaneum]>gi|270012231|gb|EFA08679.1| hypothetical protein TcasGA2_TC006347 [Tribolium castaneum] -- -- -- -- -- K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q7PN68 392 1.7e-36 Protein drumstick OS=Anopheles gambiae GN=drm PE=3 SV=1 PF13465//PF00096//PF01155//PF13912//PF00643//PF02892//PF00412 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C2H2-type zinc finger//B-box zinc finger//BED zinc finger//LIM domain GO:0006464 cellular protein modification process GO:0046872//GO:0016151//GO:0003677//GO:0003676//GO:0008270 metal ion binding//nickel cation binding//DNA binding//nucleic acid binding//zinc ion binding GO:0005622 intracellular KOG1721 FOG: Zn-finger Cluster-8309.17115 BF_2 24.00 1.57 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17117 BF_2 73.00 2.29 1621 167234380 NP_001107813.1 1053 8.3e-112 glass bottom boat protein precursor [Tribolium castaneum]>gi|270008197|gb|EFA04645.1| glass bottom boat [Tribolium castaneum] 645016200 XM_001603826.3 83 5.27313e-33 PREDICTED: Nasonia vitripennis protein 60A (LOC100120216), mRNA K16621 BMP7 bone morphogenetic protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K16621 Q24735 837 3.8e-88 Protein 60A OS=Drosophila virilis GN=gbb PE=3 SV=1 PF00688//PF00019 TGF-beta propeptide//Transforming growth factor beta like domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.17122 BF_2 85.00 2.35 1798 189235467 XP_001814003.1 688 1.9e-69 PREDICTED: chymotrypsin-1 [Tribolium castaneum]>gi|270004829|gb|EFA01277.1| serine protease P40 [Tribolium castaneum] -- -- -- -- -- K09635 TMPRSS4 transmembrane protease, serine 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09635 Q7SIG2 426 1.9e-40 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF07525//PF00089 SOCS box//Trypsin GO:0006508//GO:0035556 proteolysis//intracellular signal transduction GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.17124 BF_2 59.12 1.46 1983 478252725 ENN73120.1 1528 8.5e-167 hypothetical protein YQE_10261, partial [Dendroctonus ponderosae] -- -- -- -- -- K18398 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18398 Q0VA77 603 6.3e-61 Bis(5'-adenosyl)-triphosphatase enpp4 OS=Xenopus tropicalis GN=enpp4 PE=2 SV=1 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase -- -- GO:0003824 catalytic activity -- -- KOG2645 Type I phosphodiesterase/nucleotide pyrophosphatase Cluster-8309.17132 BF_2 20.54 0.67 1568 91085557 XP_966821.1 810 1.2e-83 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 319 4.3e-28 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13371//PF13181//PF00515//PF13414//PF00254//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.17133 BF_2 26.90 0.37 3292 642915430 XP_008190612.1 1102 3.5e-117 PREDICTED: WD repeat-containing protein 75 [Tribolium castaneum]>gi|270004005|gb|EFA00453.1| hypothetical protein TcasGA2_TC003309 [Tribolium castaneum] -- -- -- -- -- K14552 NAN1, UTP17, WDR75 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) http://www.genome.jp/dbget-bin/www_bget?ko:K14552 Q8IWA0 430 1.2e-40 WD repeat-containing protein 75 OS=Homo sapiens GN=WDR75 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1963 WD40 repeat protein Cluster-8309.17136 BF_2 282.67 1.43 8584 478255227 ENN75456.1 9118 0.0e+00 hypothetical protein YQE_08006, partial [Dendroctonus ponderosae] 759045107 XM_011333192.1 97 4.68543e-40 PREDICTED: Cerapachys biroi protein sidekick (LOC105275958), transcript variant X4, mRNA K16353 SDK protein sidekick http://www.genome.jp/dbget-bin/www_bget?ko:K16353 O97394 7458 0.0e+00 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF07646//PF02404//PF16656//PF07354//PF13895//PF00041 Kelch motif//Stem cell factor//Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0007339//GO:0007165//GO:0006771//GO:0007155 hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//signal transduction//riboflavin metabolic process//cell adhesion GO:0005515//GO:0005173//GO:0046872//GO:0003993 protein binding//stem cell factor receptor binding//metal ion binding//acid phosphatase activity GO:0016020//GO:0005576 membrane//extracellular region KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.17137 BF_2 2.00 0.92 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17139 BF_2 71.21 1.18 2822 236468408 NP_001153625.1 1219 8.2e-131 spaetzle 3 [Tribolium castaneum] 817194790 XM_012417488.1 155 8.75045e-73 PREDICTED: Orussus abietinus uncharacterized LOC105695690 (LOC105695690), mRNA -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.17141 BF_2 35.74 1.40 1353 478259252 ENN79154.1 861 1.3e-89 hypothetical protein YQE_04340, partial [Dendroctonus ponderosae]>gi|546678412|gb|ERL89035.1| hypothetical protein D910_06413 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y2C2 296 1.7e-25 Uronyl 2-sulfotransferase OS=Homo sapiens GN=UST PE=2 SV=1 PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane KOG3922 Sulfotransferases Cluster-8309.17143 BF_2 25.00 1.48 995 478256535 ENN76719.1 437 1.4e-40 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 334 5.0e-30 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13912//PF16622//PF13465//PF05864//PF00518//PF06467//PF00096//PF02176 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Early Protein (E6)//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C2H2 type//TRAF-type zinc finger GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0042025 nucleolus//host cell nucleus -- -- Cluster-8309.17145 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.17147 BF_2 19.00 7.61 390 677545672 KFR06778.1 505 7.0e-49 Elongation factor 1-alpha 2, partial [Nipponia nippon] 115451088 NM_001055680.1 369 0 Oryza sativa Japonica Group Os03g0177400 (Os03g0177400) mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q41803 538 4.3e-54 Elongation factor 1-alpha OS=Zea mays GN=EF1A PE=3 SV=1 PF01926//PF01580//PF00503//PF00437 50S ribosome-binding GTPase//FtsK/SpoIIIE family//G-protein alpha subunit//Type II/IV secretion system protein GO:0006810//GO:0007165//GO:0007186 transport//signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005524//GO:0003677//GO:0031683//GO:0000166//GO:0005525//GO:0019001//GO:0004871 GTPase activity//ATP binding//DNA binding//G-protein beta/gamma-subunit complex binding//nucleotide binding//GTP binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.17149 BF_2 18.77 1.94 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17150 BF_2 7.00 10.90 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17151 BF_2 2.00 9.61 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17153 BF_2 10.00 1.99 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17155 BF_2 213.66 8.47 1342 91085455 XP_969485.1 152 2.1e-07 PREDICTED: WASH complex subunit FAM21A [Tribolium castaneum]>gi|270009171|gb|EFA05619.1| hypothetical protein TcasGA2_TC015827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17156 BF_2 45.13 0.96 2245 91083281 XP_974400.1 2039 5.4e-226 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|270007725|gb|EFA04173.1| hypothetical protein TcasGA2_TC014422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.17158 BF_2 257.65 3.46 3398 642923271 XP_008193684.1 3688 0.0e+00 PREDICTED: protein FAN-like [Tribolium castaneum]>gi|642923273|ref|XP_008193685.1| PREDICTED: protein FAN-like [Tribolium castaneum] -- -- -- -- -- K18953 NSMAF, FAN factor associated with neutral sphingomyelinase activation http://www.genome.jp/dbget-bin/www_bget?ko:K18953 Q92636 1606 5.4e-177 Protein FAN OS=Homo sapiens GN=NSMAF PE=1 SV=2 PF00400//PF11605//PF16836//PF07569 WD domain, G-beta repeat//Vacuolar protein sorting protein 36 Vps36//Shu complex component Psy3, DNA-binding description//TUP1-like enhancer of split GO:0006355//GO:0000725 regulation of transcription, DNA-templated//recombinational repair GO:0043130//GO:0032266//GO:0005515 ubiquitin binding//phosphatidylinositol-3-phosphate binding//protein binding GO:0005634//GO:0097196 nucleus//Shu complex KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.17161 BF_2 80.81 2.66 1558 646700550 KDR10660.1 1207 1.1e-129 Cyclin-C [Zootermopsis nevadensis] -- -- -- -- -- K15161 CCNC, SSN8 cyclin C http://www.genome.jp/dbget-bin/www_bget?ko:K15161 Q7QB13 1193 1.9e-129 Cyclin-C OS=Anopheles gambiae GN=CycC PE=3 SV=2 PF00382//PF02984 Transcription factor TFIIB repeat//Cyclin, C-terminal domain -- -- GO:0017025 TBP-class protein binding GO:0005634 nucleus KOG0794 CDK8 kinase-activating protein cyclin C Cluster-8309.17162 BF_2 4.00 0.49 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09034 TRADD, N-terminal domain GO:0043123//GO:0007165 positive regulation of I-kappaB kinase/NF-kappaB signaling//signal transduction GO:0005515//GO:0004871 protein binding//signal transducer activity -- -- -- -- Cluster-8309.17164 BF_2 76.00 0.86 3996 642928273 XP_008195514.1 2990 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: pikachurin [Tribolium castaneum] 815825151 XM_012378522.1 67 1.03199e-23 PREDICTED: Linepithema humile pikachurin (LOC105678841), mRNA -- -- -- -- Q63HQ2 1013 3.7e-108 Pikachurin OS=Homo sapiens GN=EGFLAM PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.17165 BF_2 7.00 0.57 800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17170 BF_2 1.00 3.52 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17173 BF_2 50.10 0.71 3256 283046724 NP_001164308.1 1031 5.9e-109 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 405 9.5e-38 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF00520 Ion transport protein GO:0006810//GO:0006811//GO:0055085 transport//ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.17174 BF_2 13.00 0.61 1174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17175 BF_2 15.96 0.47 1693 642923490 XP_008193532.1 1341 3.5e-145 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 57 1.56556e-18 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 884 1.4e-93 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417 fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.17176 BF_2 12.35 0.55 1228 91083443 XP_970123.1 992 7.4e-105 PREDICTED: tryptophan--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 Q9UGM6 647 3.1e-66 Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens GN=WARS2 PE=1 SV=1 PF04904//PF00579 NAB conserved region 1 (NCD1)//tRNA synthetases class I (W and Y) GO:0006418//GO:0045892 tRNA aminoacylation for protein translation//negative regulation of transcription, DNA-templated GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005634 nucleus KOG2713 Mitochondrial tryptophanyl-tRNA synthetase Cluster-8309.17179 BF_2 8.02 0.61 840 478262128 ENN81013.1 174 3.6e-10 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17182 BF_2 21.18 0.45 2268 189234066 XP_970272.2 1149 8.6e-123 PREDICTED: calcium uptake protein 3, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CTY5 569 6.4e-57 Calcium uptake protein 3, mitochondrial OS=Mus musculus GN=Micu3 PE=2 SV=2 PF13833//PF13405//PF00036//PF13499//PF13202//PF12763 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.17184 BF_2 91.00 12.17 600 91086153 XP_969640.1 334 7.3e-29 PREDICTED: brachyurin-like [Tribolium castaneum] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 Q00871 302 1.5e-26 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.17188 BF_2 293.00 8.72 1693 642915761 XP_008200069.1 1878 1.9e-207 PREDICTED: cleft lip and palate transmembrane protein 1-like protein [Tribolium castaneum]>gi|642915763|ref|XP_008200070.1| PREDICTED: cleft lip and palate transmembrane protein 1-like protein [Tribolium castaneum]>gi|270003133|gb|EEZ99580.1| hypothetical protein TcasGA2_TC001566 [Tribolium castaneum] 752401280 XM_002918833.2 123 3.20238e-55 PREDICTED: Ailuropoda melanoleuca CLPTM1-like (CLPTM1L), transcript variant X2, mRNA -- -- -- -- Q5ZKJ0 1136 8.5e-123 Cleft lip and palate transmembrane protein 1-like protein OS=Gallus gallus GN=CLPTM1L PE=2 SV=1 PF09268//PF05602//PF03104 Clathrin, heavy-chain linker//Cleft lip and palate transmembrane protein 1 (CLPTM1)//DNA polymerase family B, exonuclease domain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008408//GO:0005198 3'-5' exonuclease activity//structural molecule activity GO:0030132//GO:0016021//GO:0030130 clathrin coat of coated pit//integral component of membrane//clathrin coat of trans-Golgi network vesicle KOG2489 Transmembrane protein Cluster-8309.17189 BF_2 5.00 0.58 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17190 BF_2 6.00 0.42 880 641647727 XP_008179395.1 176 2.2e-10 PREDICTED: jerky protein homolog-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17192 BF_2 10.00 0.69 895 307178776 EFN67382.1 362 6.1e-32 Transposable element Tc3 transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17193 BF_2 9.00 0.83 740 861617233 KMQ86537.1 348 2.1e-30 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17194 BF_2 179.30 5.22 1725 91082813 XP_968677.1 1380 1.1e-149 PREDICTED: transmembrane protein 43 homolog [Tribolium castaneum]>gi|270007099|gb|EFA03547.1| hypothetical protein TcasGA2_TC013551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSB9 769 3.1e-80 Transmembrane protein 43 homolog OS=Drosophila melanogaster GN=CG8111 PE=2 SV=1 PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.17196 BF_2 2.00 0.52 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17197 BF_2 21.61 4.99 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08430//PF07810 Forkhead N-terminal region//TMC domain -- -- GO:0019904//GO:0008134 protein domain specific binding//transcription factor binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.17199 BF_2 108.67 1.34 3691 478257569 ENN77723.1 257 3.8e-19 hypothetical protein YQE_05794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17200 BF_2 23.00 1.09 1166 332374402 AEE62342.1 443 3.2e-41 unknown [Dendroctonus ponderosae]>gi|478259316|gb|ENN79218.1| hypothetical protein YQE_04402, partial [Dendroctonus ponderosae]>gi|546675054|gb|ERL86309.1| hypothetical protein D910_03717 [Dendroctonus ponderosae] 153928954 AK284256.1 122 7.85683e-55 Gryllus bimaculatus mRNA, GBcontig31117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17207 BF_2 20.27 1.39 897 546683481 ERL93287.1 872 4.5e-91 hypothetical protein D910_10583 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P3S1 547 8.9e-55 DENN domain-containing protein 1B OS=Homo sapiens GN=DENND1B PE=1 SV=1 PF00787//PF06144 PX domain//DNA polymerase III, delta subunit GO:0006260 DNA replication GO:0003677//GO:0035091//GO:0003887 DNA binding//phosphatidylinositol binding//DNA-directed DNA polymerase activity GO:0009360//GO:0042575 DNA polymerase III complex//DNA polymerase complex KOG3569 RAS signaling inhibitor ST5 Cluster-8309.17210 BF_2 130.00 4.91 1394 478255359 ENN75585.1 589 4.6e-58 hypothetical protein YQE_07928, partial [Dendroctonus ponderosae] -- -- -- -- -- K17619 MDP1 magnesium-dependent phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17619 Q9D967 463 7.6e-45 Magnesium-dependent phosphatase 1 OS=Mus musculus GN=Mdp1 PE=1 SV=1 PF04551//PF12689 GcpE protein//Acid Phosphatase GO:0016114//GO:0055114 terpenoid biosynthetic process//oxidation-reduction process GO:0046429//GO:0016791 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//phosphatase activity -- -- KOG4549 Magnesium-dependent phosphatase Cluster-8309.17212 BF_2 16.00 5.09 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17215 BF_2 27.90 0.90 1589 478250608 ENN71100.1 1363 9.2e-148 hypothetical protein YQE_12033, partial [Dendroctonus ponderosae] -- -- -- -- -- K02328 POLD2 DNA polymerase delta subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02328 Q9W088 751 3.5e-78 DNA polymerase delta small subunit OS=Drosophila melanogaster GN=CG12018 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG2732 DNA polymerase delta, regulatory subunit 55 Cluster-8309.17218 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17221 BF_2 92.65 7.57 799 189233768 XP_001814337.1 458 4.0e-43 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 330 1.2e-29 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086//PF01529 Jagunal, ER re-organisation during oogenesis//DHHC palmitoyltransferase GO:0007029 endoplasmic reticulum organization GO:0008270 zinc ion binding GO:0005789 endoplasmic reticulum membrane KOG4054 Uncharacterized conserved protein Cluster-8309.17222 BF_2 67.65 3.03 1222 189233768 XP_001814337.1 678 1.9e-68 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 517 3.7e-51 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane KOG4054 Uncharacterized conserved protein Cluster-8309.17224 BF_2 499.91 2.71 7990 546671878 ERL83997.1 3673 0.0e+00 hypothetical protein D910_01313 [Dendroctonus ponderosae]>gi|546679661|gb|ERL90088.1| hypothetical protein D910_07442 [Dendroctonus ponderosae] -- -- -- -- -- K17935 SNX29 sorting nexin-29 http://www.genome.jp/dbget-bin/www_bget?ko:K17935 Q9VKB9 1413 3.0e-154 Rab3 GTPase-activating protein regulatory subunit OS=Drosophila melanogaster GN=rab3-GAP PE=1 SV=2 PF00787//PF04977//PF00957 PX domain//Septum formation initiator//Synaptobrevin GO:0016192//GO:0007049 vesicle-mediated transport//cell cycle GO:0035091 phosphatidylinositol binding GO:0016021 integral component of membrane KOG2727 Rab3 GTPase-activating protein, non-catalytic subunit Cluster-8309.17230 BF_2 19.26 1.15 989 270012927 EFA09375.1 198 7.0e-13 hypothetical protein TcasGA2_TC001936 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17231 BF_2 577.00 108.25 510 91078008 XP_969762.1 276 3.3e-22 PREDICTED: fatty acid-binding protein, liver [Tribolium castaneum]>gi|270002862|gb|EEZ99309.1| cellular FABP-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4VBT1 128 1.9e-06 Fatty acid binding protein 1-B.1 OS=Danio rerio GN=fabp1b.1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17234 BF_2 213.87 4.98 2083 478254355 ENN74607.1 415 1.0e-37 hypothetical protein YQE_08728, partial [Dendroctonus ponderosae]>gi|546677887|gb|ERL88637.1| hypothetical protein D910_06021 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28DG6 138 5.5e-07 LysM and putative peptidoglycan-binding domain-containing protein 3 OS=Xenopus tropicalis GN=lysmd3 PE=2 SV=1 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17235 BF_2 171.41 1.86 4143 642911476 XP_008199440.1 3891 0.0e+00 PREDICTED: protein dispatched isoform X2 [Tribolium castaneum] 642911477 XM_008201219.1 185 2.71435e-89 PREDICTED: Tribolium castaneum protein dispatched (LOC662282), transcript variant X3, mRNA -- -- -- -- Q9VNJ5 1929 2.3e-214 Protein dispatched OS=Drosophila melanogaster GN=disp PE=1 SV=1 PF03176//PF02460//PF00873 MMPL family//Patched family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane KOG3664 Predicted patched transmembrane receptor Cluster-8309.17239 BF_2 18.00 7.34 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17240 BF_2 82.81 2.25 1830 642923010 XP_973133.3 1144 2.6e-122 PREDICTED: transcription factor GATA-4-like isoform X1 [Tribolium castaneum] 795168618 XM_011942824.1 82 2.14648e-32 PREDICTED: Colobus angolensis palliatus GATA binding protein 4 (GATA4), mRNA K17896 GATA5 GATA-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17896 P43695 557 1.3e-55 GATA-binding factor 5-A OS=Xenopus laevis GN=gata5-a PE=2 SV=1 PF01412//PF01873//PF00320//PF08273//PF08752 Putative GTPase activating protein for Arf//Domain found in IF2B/IF5//GATA zinc finger//Zinc-binding domain of primase-helicase//Coatomer gamma subunit appendage platform subdomain GO:0006886//GO:0016192//GO:0006269//GO:0006355//GO:0006351//GO:0006446//GO:0006413 intracellular protein transport//vesicle-mediated transport//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//transcription, DNA-templated//regulation of translational initiation//translational initiation GO:0003896//GO:0005096//GO:0003743//GO:0005198//GO:0043565//GO:0008270//GO:0003700//GO:0004386 DNA primase activity//GTPase activator activity//translation initiation factor activity//structural molecule activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//helicase activity GO:0030126//GO:0005840//GO:0005730//GO:0005657//GO:0005667 COPI vesicle coat//ribosome//nucleolus//replication fork//transcription factor complex KOG1601 GATA-4/5/6 transcription factors Cluster-8309.17244 BF_2 63.00 13.58 481 584482886 AHJ09940.1 618 6.8e-62 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- O59925 346 9.7e-32 Polygalacturonase OS=Penicillium expansum GN=PEPG1 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.17246 BF_2 4.00 0.37 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17249 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1725 BF_2 3.85 0.56 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17250 BF_2 3.00 1.18 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17252 BF_2 72.02 0.37 8533 478261817 ENN80940.1 1262 2.6e-135 hypothetical protein YQE_02645, partial [Dendroctonus ponderosae]>gi|546673708|gb|ERL85267.1| hypothetical protein D910_02688 [Dendroctonus ponderosae] -- -- -- -- -- K05610 UCHL5, UCH37 ubiquitin carboxyl-terminal hydrolase L5 http://www.genome.jp/dbget-bin/www_bget?ko:K05610 Q9XSJ0 1055 1.1e-112 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos taurus GN=UCHL5 PE=2 SV=1 PF01404//PF00397//PF00552//PF02845//PF05190//PF01088 Ephrin receptor ligand binding domain//WW domain//Integrase DNA binding domain//CUE domain//MutS family domain IV//Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0016579//GO:0006508//GO:0048013//GO:0006511//GO:0006298 protein deubiquitination//proteolysis//ephrin receptor signaling pathway//ubiquitin-dependent protein catabolic process//mismatch repair GO:0003676//GO:0030983//GO:0005515//GO:0004843//GO:0005524 nucleic acid binding//mismatched DNA binding//protein binding//ubiquitin-specific protease activity//ATP binding GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.17254 BF_2 8.08 1.63 495 728418046 AIY68355.1 365 1.5e-32 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 204 2.9e-15 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17256 BF_2 60.00 1.88 1622 642919519 XP_008191907.1 1136 2.0e-121 PREDICTED: transposon Ty3-G Gag-Pol polyprotein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O93209 301 5.4e-26 Pro-Pol polyprotein OS=Feline foamy virus GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.17262 BF_2 30.34 1.22 1326 546679847 ERL90235.1 751 7.1e-77 hypothetical protein D910_07588 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09024 285 3.2e-24 Neural/ectodermal development factor IMP-L2 OS=Drosophila melanogaster GN=ImpL2 PE=1 SV=4 PF07354//PF13895 Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain GO:0007339 binding of sperm to zona pellucida GO:0005515 protein binding GO:0005576 extracellular region KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.17263 BF_2 199.63 9.90 1131 546679847 ERL90235.1 751 6.1e-77 hypothetical protein D910_07588 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09024 285 2.7e-24 Neural/ectodermal development factor IMP-L2 OS=Drosophila melanogaster GN=ImpL2 PE=1 SV=4 PF13895//PF07354 Immunoglobulin domain//Zona-pellucida-binding protein (Sp38) GO:0007339 binding of sperm to zona pellucida GO:0005515 protein binding GO:0005576 extracellular region KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.17266 BF_2 14.25 0.71 1131 642924008 XP_008193967.1 613 6.1e-61 PREDICTED: ran-binding protein 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P69566 243 2.0e-19 Ran-binding protein 9 OS=Mus musculus GN=Ranbp9 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17268 BF_2 16.00 0.97 978 642939110 XP_008198338.1 163 8.0e-09 PREDICTED: uncharacterized protein LOC103314336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF02954//PF02376 Transposase//Bacterial regulatory protein, Fis family//CUT domain GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.17269 BF_2 21.00 1.00 1168 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17272 BF_2 72.39 1.28 2652 91077788 XP_969244.1 928 4.3e-97 PREDICTED: potassium channel subfamily K member 6-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K04912 KCNK1 potassium channel subfamily K member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04912 O00180 511 4.0e-50 Potassium channel subfamily K member 1 OS=Homo sapiens GN=KCNK1 PE=1 SV=1 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.17277 BF_2 105.46 0.99 4747 189234041 XP_967848.2 2749 5.3e-308 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H2Y9 651 4.1e-66 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF07690//PF03137//PF07062//PF07648 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Clc-like//Kazal-type serine protease inhibitor domain GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215//GO:0005515 transporter activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.17282 BF_2 177.15 2.56 3181 642922818 XP_008193338.1 1625 7.7e-178 PREDICTED: lachesin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24372 354 7.6e-32 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17283 BF_2 202.85 3.08 3040 642922822 XP_008193340.1 1534 2.6e-167 PREDICTED: neurotrimin-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99PJ0 353 9.5e-32 Neurotrimin OS=Mus musculus GN=Ntm PE=2 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17285 BF_2 12.00 0.32 1853 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17286 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17290 BF_2 6.04 0.39 934 240849007 NP_001155630.1 149 3.2e-07 apoptosis-linked protein 2-like [Acyrthosiphon pisum]>gi|239799486|dbj|BAH70661.1| ACYPI005521 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17291 BF_2 3.00 0.48 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17292 BF_2 20.23 0.52 1924 478254753 ENN74990.1 349 4.2e-30 hypothetical protein YQE_08447, partial [Dendroctonus ponderosae] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q76B49 157 3.2e-09 CD63 antigen OS=Felis catus GN=CD63 PE=2 SV=3 PF00335//PF01299 Tetraspanin family//Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.17296 BF_2 46.87 2.14 1204 189237943 XP_001811459.1 1204 1.9e-129 PREDICTED: WD repeat domain-containing protein 83 [Tribolium castaneum] -- -- -- -- -- K13124 MORG1 mitogen-activated protein kinase organizer 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13124 Q9DAJ4 791 6.1e-83 WD repeat domain-containing protein 83 OS=Mus musculus GN=Wdr83 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0316 Conserved WD40 repeat-containing protein Cluster-8309.17297 BF_2 24.34 1.47 981 91083169 XP_972121.1 340 2.4e-29 PREDICTED: uncharacterized protein LOC660825 [Tribolium castaneum]>gi|270007697|gb|EFA04145.1| hypothetical protein TcasGA2_TC014389 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.17303 BF_2 3.00 1.68 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17309 BF_2 39.36 0.75 2480 668462962 KFB50405.1 685 6.0e-69 AGAP005747-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q96NJ6 204 1.5e-14 Zinc finger protein 3 homolog OS=Homo sapiens GN=ZFP3 PE=2 SV=1 PF00651//PF13912//PF07975//PF00130//PF00096//PF13465 BTB/POZ domain//C2H2-type zinc finger//TFIIH C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0035556//GO:0006281 intracellular signal transduction//DNA repair GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.17311 BF_2 106.69 1.46 3347 546676453 ERL87458.1 1811 2.2e-199 hypothetical protein D910_04850 [Dendroctonus ponderosae] -- -- -- -- -- K18470 ARHGAP1, CDC42GAP Rho GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18470 Q07960 857 3.8e-90 Rho GTPase-activating protein 1 OS=Homo sapiens GN=ARHGAP1 PE=1 SV=1 PF00620//PF06151 RhoGAP domain//Trehalose receptor GO:0007607//GO:0007187//GO:0050912//GO:0007165 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//signal transduction GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.17314 BF_2 456.15 5.66 3661 546676453 ERL87458.1 1811 2.4e-199 hypothetical protein D910_04850 [Dendroctonus ponderosae] -- -- -- -- -- K18470 ARHGAP1, CDC42GAP Rho GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18470 Q07960 857 4.1e-90 Rho GTPase-activating protein 1 OS=Homo sapiens GN=ARHGAP1 PE=1 SV=1 PF00620//PF06151 RhoGAP domain//Trehalose receptor GO:0007607//GO:0007187//GO:0050912//GO:0007165 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//signal transduction GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.17320 BF_2 12.00 0.49 1318 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17322 BF_2 22.23 0.69 1626 91080979 XP_974925.1 843 1.9e-87 PREDICTED: uncharacterized protein LOC663797 [Tribolium castaneum]>gi|270005969|gb|EFA02417.1| hypothetical protein TcasGA2_TC008102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17324 BF_2 7.00 0.58 788 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17328 BF_2 3.07 0.42 590 642933293 XP_968154.2 375 1.3e-33 PREDICTED: putative ribosomal RNA methyltransferase CG11447 [Tribolium castaneum] -- -- -- -- -- K02427 rlmE, rrmJ, ftsJ 23S rRNA (uridine2552-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02427 Q9VDT6 276 1.6e-23 rRNA methyltransferase 2, mitochondrial OS=Drosophila melanogaster GN=CG11447 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ Cluster-8309.17329 BF_2 250.64 11.36 1210 91077632 XP_974008.1 1058 1.6e-112 PREDICTED: venom acid phosphatase Acph-1 [Tribolium castaneum]>gi|270002186|gb|EEZ98633.1| hypothetical protein TcasGA2_TC001160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLY5 462 8.6e-45 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.1733 BF_2 2.00 0.67 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17330 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17331 BF_2 31.64 0.45 3254 642927984 XP_008195472.1 735 1.3e-74 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17333 BF_2 4.65 0.78 538 642926860 XP_971810.2 147 3.1e-07 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF00096 zinc-finger C2H2-type//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.17336 BF_2 152.00 3.95 1898 270012606 EFA09054.1 424 8.4e-39 hypothetical protein TcasGA2_TC006767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01698 Floricaula / Leafy protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.17337 BF_2 5.00 0.39 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17340 BF_2 13.22 1.35 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17342 BF_2 68.00 0.67 4519 642918165 XP_008191394.1 232 3.7e-16 PREDICTED: mucin-22 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17347 BF_2 180.96 1.91 4250 91089065 XP_970808.1 2413 4.3e-269 PREDICTED: protein brunelleschi [Tribolium castaneum]>gi|642932680|ref|XP_008196943.1| PREDICTED: protein brunelleschi [Tribolium castaneum]>gi|642932683|ref|XP_008196944.1| PREDICTED: protein brunelleschi [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96Q05 1060 1.4e-113 Trafficking protein particle complex subunit 9 OS=Homo sapiens GN=TRAPPC9 PE=1 SV=2 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG1953 Targeting complex (TRAPP) subunit Cluster-8309.17348 BF_2 2.00 0.60 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17349 BF_2 20.86 1.10 1077 642926185 XP_008194821.1 484 5.3e-46 PREDICTED: deleted in azoospermia protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24207 333 7.0e-30 Protein boule OS=Drosophila melanogaster GN=bol PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.17353 BF_2 72.72 0.70 4639 91083873 XP_974306.1 619 5.0e-61 PREDICTED: uncharacterized protein LOC663153 [Tribolium castaneum]>gi|270007945|gb|EFA04393.1| hypothetical protein TcasGA2_TC014692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 230 2.7e-17 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF07469//PF04923//PF01884 Domain of unknown function (DUF1518)//Ninjurin//PcrB family GO:0042246//GO:0007155 tissue regeneration//cell adhesion GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.17355 BF_2 6.00 0.82 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17358 BF_2 14.00 12.34 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17360 BF_2 334.79 7.58 2134 546672915 ERL84631.1 1392 5.4e-151 hypothetical protein D910_02059 [Dendroctonus ponderosae] -- -- -- -- -- K03842 ALG1 beta-1,4-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03842 Q5R7A2 960 2.7e-102 Chitobiosyldiphosphodolichol beta-mannosyltransferase OS=Pongo abelii GN=ALG1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2941 Beta-1,4-mannosyltransferase Cluster-8309.17362 BF_2 10.00 9.75 320 54312039 BAD66670.1 217 1.4e-15 cecropin precursor [Acalolepta luxuriosa] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00272 Cecropin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.17364 BF_2 224.57 5.08 2136 282400160 NP_001164203.1 2814 0.0e+00 cannonball [Tribolium castaneum]>gi|270008125|gb|EFA04573.1| cannonball [Tribolium castaneum] 242007793 XM_002424662.1 201 1.77155e-98 Pediculus humanus corporis transcription initiation factor TFIID subunit, putative, mRNA K03130 TAF5 transcription initiation factor TFIID subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03130 P49846 1681 6.8e-186 Transcription initiation factor TFIID subunit 5 OS=Drosophila melanogaster GN=Taf5 PE=1 SV=1 PF00039//PF00400//PF04494 Fibronectin type I domain//WD domain, G-beta repeat//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005576//GO:0005634 extracellular region//nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.17365 BF_2 273.56 1.38 8599 478255227 ENN75456.1 9075 0.0e+00 hypothetical protein YQE_08006, partial [Dendroctonus ponderosae] 759045107 XM_011333192.1 97 4.69365e-40 PREDICTED: Cerapachys biroi protein sidekick (LOC105275958), transcript variant X4, mRNA K16353 SDK protein sidekick http://www.genome.jp/dbget-bin/www_bget?ko:K16353 O97394 7400 0.0e+00 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF07646//PF00041//PF07354//PF13895//PF16656//PF02404 Kelch motif//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Stem cell factor GO:0007165//GO:0007339//GO:0019497//GO:0007155//GO:0006771 signal transduction//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//cell adhesion//riboflavin metabolic process GO:0005173//GO:0005515//GO:0003993//GO:0046872 stem cell factor receptor binding//protein binding//acid phosphatase activity//metal ion binding GO:0005576//GO:0016020 extracellular region//membrane KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.17371 BF_2 9.00 0.58 935 270007709 EFA04157.1 926 2.6e-97 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 518 2.1e-51 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF01926//PF00664//PF03193//PF00005 50S ribosome-binding GTPase//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.17373 BF_2 42.70 0.85 2378 91087387 XP_975653.1 1433 1.1e-155 PREDICTED: glucosylceramidase-like [Tribolium castaneum] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q70KH2 942 3.7e-100 Glucosylceramidase OS=Sus scrofa GN=GBA PE=3 SV=1 PF02055 O-Glycosyl hydrolase family 30 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.17375 BF_2 188.95 8.60 1206 478256984 ENN77148.1 186 2.1e-11 hypothetical protein YQE_06287, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17376 BF_2 17.00 1.38 804 759069189 XP_011344131.1 214 8.0e-15 PREDICTED: LOW QUALITY PROTEIN: ankyrin-1-like [Cerapachys biroi] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q4UMH6 177 6.4e-12 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.17378 BF_2 2.00 5.31 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1738 BF_2 31.00 1.18 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17382 BF_2 84.00 7.85 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17386 BF_2 43.54 1.03 2048 642920596 XP_008192479.1 1068 1.9e-113 PREDICTED: UPF0609 protein C4orf27 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CFE2 632 2.8e-64 UPF0609 protein C4orf27 homolog OS=Mus musculus PE=1 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17387 BF_2 51.46 1.26 2002 642920596 XP_008192479.1 678 3.1e-68 PREDICTED: UPF0609 protein C4orf27 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CFE2 386 9.3e-36 UPF0609 protein C4orf27 homolog OS=Mus musculus PE=1 SV=1 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1739 BF_2 6.00 0.38 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17390 BF_2 5.05 0.35 898 642935120 XP_008197896.1 311 5.0e-26 PREDICTED: vigilin [Tribolium castaneum]>gi|270013832|gb|EFA10280.1| hypothetical protein TcasGA2_TC012484 [Tribolium castaneum] 642935119 XM_008199674.1 49 2.28513e-14 PREDICTED: Tribolium castaneum vigilin (LOC658150), mRNA -- -- -- -- Q8VDJ3 130 2.0e-06 Vigilin OS=Mus musculus GN=Hdlbp PE=1 SV=1 -- -- -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.17394 BF_2 91.82 1.25 3351 478255117 ENN75347.1 919 5.9e-96 hypothetical protein YQE_08123, partial [Dendroctonus ponderosae] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q9UPI3 534 1.1e-52 Feline leukemia virus subgroup C receptor-related protein 2 OS=Homo sapiens GN=FLVCR2 PE=1 SV=1 PF10640//PF07690//PF03137 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006370//GO:0055085//GO:0006810 7-methylguanosine mRNA capping//transmembrane transport//transport GO:0004651//GO:0004484//GO:0005215 polynucleotide 5'-phosphatase activity//mRNA guanylyltransferase activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.17396 BF_2 82.52 1.42 2710 642937783 XP_008198943.1 1228 7.1e-132 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K14590 CMTR2, FTSJD1, AFT cap2 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14590 Q8IYT2 792 1.1e-82 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens GN=CMTR2 PE=1 SV=2 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.17398 BF_2 85.31 0.63 5983 642913222 XP_008201445.1 1357 1.7e-146 PREDICTED: uncharacterized protein LOC664141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08136//PF00884//PF05190 30S ribosomal protein subunit S22 family//Sulfatase//MutS family domain IV GO:0042254//GO:0006412//GO:0008152//GO:0006298 ribosome biogenesis//translation//metabolic process//mismatch repair GO:0008484//GO:0003735//GO:0030983//GO:0005524 sulfuric ester hydrolase activity//structural constituent of ribosome//mismatched DNA binding//ATP binding GO:0005840 ribosome -- -- Cluster-8309.17400 BF_2 292.00 6.83 2075 642910915 XP_008193463.1 1475 1.2e-160 PREDICTED: LOW QUALITY PROTEIN: nischarin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I1 675 3.0e-69 Nischarin OS=Homo sapiens GN=NISCH PE=1 SV=3 PF00787//PF13855 PX domain//Leucine rich repeat -- -- GO:0005515//GO:0035091 protein binding//phosphatidylinositol binding -- -- KOG1259 Nischarin, modulator of integrin alpha5 subunit action Cluster-8309.17402 BF_2 123.00 9.80 812 -- -- -- -- -- 44804354 AC113332.2 812 0 Oryza sativa Japonica Group chromosome 5 clone OJ1057_B02, complete sequence -- -- -- -- P29835 481 3.6e-47 19 kDa globulin OS=Oryza sativa subsp. japonica GN=Os05g0499100 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17403 BF_2 43.00 1.04 2012 91086965 XP_973158.1 1286 9.9e-139 PREDICTED: protein NEDD1 [Tribolium castaneum]>gi|270009645|gb|EFA06093.1| hypothetical protein TcasGA2_TC008935 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NHV4 359 1.3e-32 Protein NEDD1 OS=Homo sapiens GN=NEDD1 PE=1 SV=1 PF04977//PF02911//PF00400 Septum formation initiator//Formyl transferase, C-terminal domain//WD domain, G-beta repeat GO:0007049//GO:0009058 cell cycle//biosynthetic process GO:0016742//GO:0005515 hydroxymethyl-, formyl- and related transferase activity//protein binding -- -- -- -- Cluster-8309.17406 BF_2 3.00 1.38 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17408 BF_2 240.66 10.07 1287 91087191 XP_975444.1 968 4.7e-102 PREDICTED: SAGA-associated factor 29 homolog [Tribolium castaneum]>gi|270009566|gb|EFA06014.1| hypothetical protein TcasGA2_TC008842 [Tribolium castaneum] -- -- -- -- -- K11364 SGF29 SAGA-associated factor 29 http://www.genome.jp/dbget-bin/www_bget?ko:K11364 Q9DA08 648 2.5e-66 SAGA-associated factor 29 homolog OS=Mus musculus GN=Ccdc101 PE=2 SV=1 PF00631//PF08702//PF11744 GGL domain//Fibrinogen alpha/beta chain family//Aluminium activated malate transporter GO:0007186//GO:0030168//GO:0015743//GO:0051258//GO:0007165 G-protein coupled receptor signaling pathway//platelet activation//malate transport//protein polymerization//signal transduction GO:0030674//GO:0004871//GO:0005102 protein binding, bridging//signal transducer activity//receptor binding GO:0005577//GO:0005834 fibrinogen complex//heterotrimeric G-protein complex KOG3038 Histone acetyltransferase SAGA associated factor SGF29 Cluster-8309.17410 BF_2 32.23 0.36 4068 270010746 EFA07194.1 902 6.7e-94 hypothetical protein TcasGA2_TC010200 [Tribolium castaneum] -- -- -- -- -- K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 135 2.4e-06 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17411 BF_2 224.47 2.85 3578 329350997 AEB91339.1 1457 2.6e-158 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 688 1.6e-70 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05834//PF07992//PF00732//PF01266//PF02254//PF05199 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//FAD dependent oxidoreductase//TrkA-N domain//GMC oxidoreductase GO:0016117//GO:0006813//GO:0055114 carotenoid biosynthetic process//potassium ion transport//oxidation-reduction process GO:0050660//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.17412 BF_2 11.00 0.61 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17417 BF_2 157.52 0.81 8422 642912924 XP_008201308.1 4052 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] 194890784 XM_001977354.1 96 1.65324e-39 Drosophila erecta GG18278 (Dere\GG18278), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q09103 1946 5.0e-216 Eye-specific diacylglycerol kinase OS=Drosophila melanogaster GN=rdgA PE=2 SV=2 PF00781//PF00130//PF00609//PF00628//PF16866//PF13606//PF00023 Diacylglycerol kinase catalytic domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//PHD-finger//PHD-finger//Ankyrin repeat//Ankyrin repeat GO:0009395//GO:0007205//GO:0046486//GO:0035556 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//glycerolipid metabolic process//intracellular signal transduction GO:0016301//GO:0004143//GO:0005515 kinase activity//diacylglycerol kinase activity//protein binding -- -- KOG0782 Predicted diacylglycerol kinase Cluster-8309.17418 BF_2 47.54 1.47 1640 642928077 XP_008200146.1 963 2.3e-101 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 O88801 308 8.5e-27 Homer protein homolog 2 OS=Rattus norvegicus GN=Homer2 PE=1 SV=1 PF06703//PF16716//PF06810//PF04508//PF13851//PF04977//PF00038//PF07716//PF17078//PF15898//PF03938//PF10473//PF07989//PF04728//PF07926 Microsomal signal peptidase 25 kDa subunit (SPC25)//Bone marrow stromal antigen 2//Phage minor structural protein GP20//Viral A-type inclusion protein repeat//Growth-arrest specific micro-tubule binding//Septum formation initiator//Intermediate filament protein//Basic region leucine zipper//SWI5-dependent HO expression protein 3//cGMP-dependent protein kinase interacting domain//Outer membrane protein (OmpH-like)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Lipoprotein leucine-zipper//TPR/MLP1/MLP2-like protein GO:0006355//GO:0006606//GO:0007049//GO:0016032//GO:0051607//GO:0006465//GO:0051028//GO:0048309//GO:0048870 regulation of transcription, DNA-templated//protein import into nucleus//cell cycle//viral process//defense response to virus//signal peptide processing//mRNA transport//endoplasmic reticulum inheritance//cell motility GO:0043565//GO:0051082//GO:0019901//GO:0003700//GO:0008233//GO:0005198//GO:0045502//GO:0008134//GO:0042803 sequence-specific DNA binding//unfolded protein binding//protein kinase binding//transcription factor activity, sequence-specific DNA binding//peptidase activity//structural molecule activity//dynein binding//transcription factor binding//protein homodimerization activity GO:0005787//GO:0016021//GO:0005815//GO:0031514//GO:0005882//GO:0030286//GO:0019867//GO:0005667 signal peptidase complex//integral component of membrane//microtubule organizing center//motile cilium//intermediate filament//dynein complex//outer membrane//transcription factor complex -- -- Cluster-8309.17419 BF_2 40.92 0.38 4817 478250909 ENN71394.1 603 3.7e-59 hypothetical protein YQE_11898, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9QX47 328 1.2e-28 Protein SON OS=Mus musculus GN=Son PE=1 SV=2 PF05493//PF01585 ATP synthase subunit H//G-patch domain GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0003676 hydrogen ion transmembrane transporter activity//nucleic acid binding GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.17420 BF_2 1.00 1.09 314 478252125 ENN72556.1 173 1.8e-10 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10596 U6-snRNA interacting domain of PrP8 -- -- GO:0017070 U6 snRNA binding -- -- -- -- Cluster-8309.17423 BF_2 12.04 0.31 1930 668447779 KFB37519.1 608 4.0e-60 AGAP011148-PA-like protein [Anopheles sinensis] 645021074 XM_008209220.1 57 1.78935e-18 PREDICTED: Nasonia vitripennis 39S ribosomal protein L14, mitochondrial (LOC100115115), transcript variant X3, mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 Q5ZJF4 416 3.0e-39 Peroxiredoxin-6 OS=Gallus gallus GN=PRDX6 PE=2 SV=3 PF08534//PF00578//PF00238 Redoxin//AhpC/TSA family//Ribosomal protein L14p/L23e GO:0006412//GO:0055114//GO:0042254 translation//oxidation-reduction process//ribosome biogenesis GO:0016491//GO:0016209//GO:0003735 oxidoreductase activity//antioxidant activity//structural constituent of ribosome GO:0005840 ribosome KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.17424 BF_2 47.43 1.25 1875 668447779 KFB37519.1 608 3.8e-60 AGAP011148-PA-like protein [Anopheles sinensis] 645021074 XM_008209220.1 57 1.73741e-18 PREDICTED: Nasonia vitripennis 39S ribosomal protein L14, mitochondrial (LOC100115115), transcript variant X3, mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 Q5ZJF4 416 2.9e-39 Peroxiredoxin-6 OS=Gallus gallus GN=PRDX6 PE=2 SV=3 PF00238//PF08534//PF00578 Ribosomal protein L14p/L23e//Redoxin//AhpC/TSA family GO:0006412//GO:0042254//GO:0055114 translation//ribosome biogenesis//oxidation-reduction process GO:0016491//GO:0016209//GO:0003735 oxidoreductase activity//antioxidant activity//structural constituent of ribosome GO:0005840 ribosome KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.17425 BF_2 205.00 13.40 927 642924778 XP_008194436.1 513 2.0e-49 PREDICTED: U6 snRNA-associated Sm-like protein LSm4 [Tribolium castaneum] 733924353 XM_010725105.1 90 3.81482e-37 PREDICTED: Meleagris gallopavo LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (LSM4), mRNA K12623 LSM4 U6 snRNA-associated Sm-like protein LSm4 http://www.genome.jp/dbget-bin/www_bget?ko:K12623 Q9Y4Z0 471 6.0e-46 U6 snRNA-associated Sm-like protein LSm4 OS=Homo sapiens GN=LSM4 PE=1 SV=1 PF10384 Centromere protein Scm3 -- -- GO:0042393 histone binding GO:0005634 nucleus KOG3293 Small nuclear ribonucleoprotein (snRNP) Cluster-8309.17427 BF_2 282.45 11.61 1305 478253266 ENN73637.1 250 8.7e-19 hypothetical protein YQE_09883, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041//PF02018 Fibronectin type III domain//Carbohydrate binding domain -- -- GO:0005515//GO:0016798 protein binding//hydrolase activity, acting on glycosyl bonds -- -- -- -- Cluster-8309.17428 BF_2 27.55 0.67 2007 478253266 ENN73637.1 251 1.0e-18 hypothetical protein YQE_09883, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17431 BF_2 29.80 0.42 3258 642934573 XP_008197722.1 1984 1.9e-219 PREDICTED: uncharacterized protein LOC658962 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10314 FBXO39 F-box protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K10314 -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17432 BF_2 38.00 2.61 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17433 BF_2 17.00 0.39 2132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17434 BF_2 173.68 2.76 2918 642924981 XP_001811513.2 787 1.0e-80 PREDICTED: homeobox protein Mohawk [Tribolium castaneum] 462328280 APGK01040752.1 78 5.76511e-30 Dendroctonus ponderosae Seq01040762, whole genome shotgun sequence -- -- -- -- Q8IYA7 185 2.8e-12 Homeobox protein Mohawk OS=Homo sapiens GN=MKX PE=2 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.17439 BF_2 1024.00 2211.87 282 -- -- -- -- -- 195614799 EU957112.1 270 9.23655e-138 Zea mays clone 1583036 peptide transporter PTR2 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1744 BF_2 5.00 0.38 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17440 BF_2 315.00 524.41 293 -- -- -- -- -- 527047401 HG323736.1 283 5.723e-145 TPA: Zea mays SRP RNA for signal recognition particle RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17441 BF_2 260.81 3.33 3565 642930179 XP_008196287.1 1897 2.5e-209 PREDICTED: protein dead ringer isoform X1 [Tribolium castaneum] 642930178 XM_008198065.1 438 0 PREDICTED: Tribolium castaneum protein dead ringer (LOC657345), transcript variant X1, mRNA -- -- -- -- Q24573 752 6.0e-78 Protein dead ringer OS=Drosophila melanogaster GN=retn PE=1 SV=2 PF01388 ARID/BRIGHT DNA binding domain -- -- GO:0003677 DNA binding -- -- KOG2744 DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain Cluster-8309.17444 BF_2 1.00 0.45 379 189238464 XP_966906.2 254 8.7e-20 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 157 6.3e-10 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17445 BF_2 9.00 7.56 329 242018452 XP_002429689.1 327 2.6e-28 fatty acid synthase, putative [Pediculus humanus corporis]>gi|212514692|gb|EEB16951.1| fatty acid synthase, putative [Pediculus humanus corporis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 254 3.1e-21 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- GO:0042967//GO:0008152//GO:0006633 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process GO:0016491//GO:0016297//GO:0016829//GO:0005488 oxidoreductase activity//acyl-[acyl-carrier-protein] hydrolase activity//lyase activity//binding GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.17446 BF_2 1.00 4.10 259 769830483 XP_011630277.1 278 9.7e-23 PREDICTED: fatty acid synthase-like [Pogonomyrmex barbatus] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 240 1.0e-19 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.17448 BF_2 39.00 0.57 3156 270001047 EEZ97494.1 198 2.3e-12 hypothetical protein TcasGA2_TC011337 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83994 140 4.9e-07 Cuticle protein 18.6, isoform A OS=Locusta migratoria PE=1 SV=1 PF00379//PF04546 Insect cuticle protein//Sigma-70, non-essential region GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0042302//GO:0003700 DNA binding//sigma factor activity//structural constituent of cuticle//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.17449 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17453 BF_2 165.00 9.38 1023 332376089 AEE63185.1 728 2.5e-74 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P4H8 538 1.1e-53 Protein FAM173B OS=Homo sapiens GN=FAM173B PE=1 SV=2 PF08123 Histone methylation protein DOT1 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG4058 Uncharacterized conserved protein Cluster-8309.17454 BF_2 64.48 0.62 4661 478259446 ENN79336.1 1032 6.5e-109 hypothetical protein YQE_04245, partial [Dendroctonus ponderosae]>gi|546675187|gb|ERL86423.1| hypothetical protein D910_03830 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O42602 211 4.3e-15 Corticotropin-releasing factor receptor 1 OS=Xenopus laevis GN=crhr1 PE=2 SV=1 PF08655//PF02793//PF00002 DASH complex subunit Ask1//Hormone receptor domain//7 transmembrane receptor (Secretin family) GO:0008608//GO:0007186 attachment of spindle microtubules to kinetochore//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0042729//GO:0016020//GO:0072686 integral component of membrane//DASH complex//membrane//mitotic spindle -- -- Cluster-8309.17457 BF_2 9.00 0.45 1133 410509310 BAM65721.1 1365 3.9e-148 myosin heavy chain type 1 [Litopenaeus vannamei] -- -- -- -- -- K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1218 1.8e-132 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF06810//PF01920//PF13851//PF06009//PF12317//PF00038//PF07926//PF09728//PF01576//PF04111//PF06156//PF00769//PF15898//PF09177//PF10473//PF00015//PF04136 Phage minor structural protein GP20//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Laminin Domain II//Intraflagellar transport complex B protein 46 C terminal//Intermediate filament protein//TPR/MLP1/MLP2-like protein//Myosin-like coiled-coil protein//Myosin tail//Autophagy protein Apg6//Protein of unknown function (DUF972)//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family GO:0006914//GO:0006886//GO:0007165//GO:0042073//GO:0006606//GO:0006260//GO:0048870//GO:0048193//GO:0006457//GO:0007155 autophagy//intracellular protein transport//signal transduction//intraciliary transport//protein import into nucleus//DNA replication//cell motility//Golgi vesicle transport//protein folding//cell adhesion GO:0005198//GO:0008134//GO:0045502//GO:0051082//GO:0019901//GO:0019905//GO:0008092//GO:0042803//GO:0003774//GO:0004871 structural molecule activity//transcription factor binding//dynein binding//unfolded protein binding//protein kinase binding//syntaxin binding//cytoskeletal protein binding//protein homodimerization activity//motor activity//signal transducer activity GO:0005882//GO:0019898//GO:0016459//GO:0031514//GO:0005737//GO:0016272//GO:0005801//GO:0005667//GO:0030286//GO:0016020 intermediate filament//extrinsic component of membrane//myosin complex//motile cilium//cytoplasm//prefoldin complex//cis-Golgi network//transcription factor complex//dynein complex//membrane -- -- Cluster-8309.17459 BF_2 61.62 3.24 1082 478257312 ENN77472.1 207 7.0e-14 hypothetical protein YQE_06000, partial [Dendroctonus ponderosae]>gi|546679541|gb|ERL89989.1| hypothetical protein D910_07348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17462 BF_2 208.24 2.54 3715 478249944 ENN70451.1 1866 1.0e-205 hypothetical protein YQE_12955, partial [Dendroctonus ponderosae] 642934506 XM_008199471.1 152 5.37613e-71 PREDICTED: Tribolium castaneum calcium homeostasis endoplasmic reticulum protein (LOC100142080), transcript variant X3, mRNA K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8IWX8 487 3.4e-47 Calcium homeostasis endoplasmic reticulum protein OS=Homo sapiens GN=CHERP PE=1 SV=3 PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.17464 BF_2 78.00 5.65 865 91085791 XP_976450.1 551 7.2e-54 PREDICTED: uncharacterized protein LOC663387 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D0V8 158 1.1e-09 Cyclin-dependent kinase 2-interacting protein OS=Mus musculus GN=Cinp PE=2 SV=1 PF03232 Ubiquinone biosynthesis protein COQ7 GO:0006744//GO:0055114 ubiquinone biosynthetic process//oxidation-reduction process -- -- -- -- -- -- Cluster-8309.17467 BF_2 16.00 0.81 1118 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17468 BF_2 28.14 1.20 1269 642918004 XP_008198977.1 683 5.2e-69 PREDICTED: N-alpha-acetyltransferase 60 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX8 442 1.9e-42 N-alpha-acetyltransferase 60 OS=Drosophila melanogaster GN=Naa60 PE=1 SV=1 PF13302//PF13673//PF08445//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.17470 BF_2 12.00 0.33 1831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17471 BF_2 15.00 1.24 794 -- -- -- -- -- 584458492 NG_033929.1 791 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17472 BF_2 11.00 2.17 499 -- -- -- -- -- 584458492 NG_033929.1 493 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17473 BF_2 30.19 1.28 1274 478260276 ENN80028.1 271 3.1e-21 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2EI20 183 2.0e-12 RE1-silencing transcription factor OS=Danio rerio GN=rest PE=2 SV=1 PF07649//PF13465//PF00096//PF03348//PF06309 C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//Serine incorporator (Serinc)//Torsin GO:0055114 oxidation-reduction process GO:0005524//GO:0046872//GO:0047134 ATP binding//metal ion binding//protein-disulfide reductase activity GO:0016020 membrane KOG1721 FOG: Zn-finger Cluster-8309.17474 BF_2 9.64 0.36 1407 546684929 ERL94511.1 162 1.5e-08 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.17475 BF_2 81.03 0.96 3828 642935735 XP_008198150.1 1598 1.3e-174 PREDICTED: RNA polymerase II-associated protein 1 [Tribolium castaneum]>gi|270013972|gb|EFA10420.1| hypothetical protein TcasGA2_TC012660 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JN53 482 1.3e-46 RNA polymerase II-associated protein 1 OS=Bos taurus GN=RPAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4732 Uncharacterized conserved protein Cluster-8309.17476 BF_2 224.15 5.86 1887 91077926 XP_974115.1 793 1.4e-81 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9X248 307 1.3e-26 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=fabG PE=3 SV=1 PF00106//PF01370//PF02826//PF02076//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Pheromone A receptor//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114//GO:0007606//GO:0019236//GO:0007186 metabolic process//oxidation-reduction process//sensory perception of chemical stimulus//response to pheromone//G-protein coupled receptor signaling pathway GO:0051287//GO:0016491//GO:0003824//GO:0050662//GO:0004932 NAD binding//oxidoreductase activity//catalytic activity//coenzyme binding//mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.17477 BF_2 4.00 4.11 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17479 BF_2 59.05 1.06 2617 642912496 XP_008200890.1 1793 2.1e-197 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LUQ4 218 3.7e-16 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.1748 BF_2 1.00 4.36 257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17483 BF_2 6.00 0.33 1055 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17487 BF_2 111.41 6.16 1044 91079358 XP_970171.1 573 2.4e-56 PREDICTED: ankyrin repeat domain-containing protein 54 [Tribolium castaneum]>gi|270003493|gb|EEZ99940.1| hypothetical protein TcasGA2_TC002736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NXT1 323 9.8e-29 Ankyrin repeat domain-containing protein 54 OS=Homo sapiens GN=ANKRD54 PE=1 SV=2 PF00023//PF13606//PF00831 Ankyrin repeat//Ankyrin repeat//Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.17488 BF_2 16.21 0.92 1022 270006188 EFA02636.1 776 6.9e-80 hypothetical protein TcasGA2_TC008357 [Tribolium castaneum] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 P07190 503 1.3e-49 Maltase A1 OS=Drosophila melanogaster GN=Mal-A1 PE=2 SV=2 PF00128 Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824 cation binding//catalytic activity -- -- -- -- Cluster-8309.17489 BF_2 40.60 1.13 1795 91081575 XP_975220.1 1589 6.5e-174 PREDICTED: maltase 2-like [Tribolium castaneum] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 O16098 1265 9.9e-138 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128//PF02284 Alpha amylase, catalytic domain//Cytochrome c oxidase subunit Va GO:0015992//GO:0005975//GO:0006123 proton transport//carbohydrate metabolic process//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0043169//GO:0003824 cytochrome-c oxidase activity//cation binding//catalytic activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane -- -- Cluster-8309.17490 BF_2 47.31 0.84 2637 91077430 XP_966364.1 2481 3.5e-277 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [Tribolium castaneum]>gi|270001627|gb|EEZ98074.1| hypothetical protein TcasGA2_TC000481 [Tribolium castaneum] 752892703 XM_011266149.1 450 0 PREDICTED: Camponotus floridanus putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 (LOC105256330), mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 Q5RAZ4 2035 7.5e-227 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Pongo abelii GN=DHX15 PE=2 SV=2 PF00005//PF04851//PF09339//PF00270//PF07652//PF01695//PF00063//PF04408//PF00437//PF00448 ABC transporter//Type III restriction enzyme, res subunit//IclR helix-turn-helix domain//DEAD/DEAH box helicase//Flavivirus DEAD domain//IstB-like ATP binding protein//Myosin head (motor domain)//Helicase associated domain (HA2)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006810//GO:0006614//GO:0019079//GO:0006355 transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication//regulation of transcription, DNA-templated GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0004386//GO:0003676//GO:0016887//GO:0003774//GO:0005525 ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//helicase activity//nucleic acid binding//ATPase activity//motor activity//GTP binding GO:0016459 myosin complex KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.17493 BF_2 9.75 0.85 766 546677295 ERL88156.1 522 1.5e-50 hypothetical protein D910_05544 [Dendroctonus ponderosae] -- -- -- -- -- K14696 SLC30A9, ZNT9 solute carrier family 30 (zinc transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14696 Q5PQZ3 367 5.7e-34 Zinc transporter 9 OS=Danio rerio GN=slc30a9 PE=2 SV=1 PF01545 Cation efflux family GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG2802 Membrane protein HUEL (cation efflux superfamily) Cluster-8309.17497 BF_2 2.00 0.64 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17500 BF_2 44.90 2.93 929 270000856 EEZ97303.1 236 2.6e-17 hypothetical protein TcasGA2_TC011112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17502 BF_2 6.05 0.65 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17503 BF_2 132.00 9.97 841 642927984 XP_008195472.1 371 5.2e-33 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08360 QacR-like protein, C-terminal region GO:0045892 negative regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.17504 BF_2 128.00 8.88 890 642927984 XP_008195472.1 369 9.4e-33 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17507 BF_2 2.00 0.38 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17509 BF_2 11.00 0.91 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17514 BF_2 260.47 5.05 2444 642916262 XP_008190953.1 1208 1.3e-129 PREDICTED: thyrotropin-releasing hormone receptor isoform X3 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.6e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.17516 BF_2 98.62 3.08 1625 642937952 XP_970081.3 405 1.2e-36 PREDICTED: uncharacterized protein LOC658612 isoform X2 [Tribolium castaneum]>gi|270015689|gb|EFA12137.1| hypothetical protein TcasGA2_TC002283 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17517 BF_2 49.06 0.57 3894 642937952 XP_970081.3 240 3.7e-17 PREDICTED: uncharacterized protein LOC658612 isoform X2 [Tribolium castaneum]>gi|270015689|gb|EFA12137.1| hypothetical protein TcasGA2_TC002283 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17518 BF_2 55.49 1.98 1460 823414644 XP_012414975.1 292 1.3e-23 PREDICTED: zinc finger protein 883-like [Trichechus manatus latirostris] -- -- -- -- -- K09233 GLIS2 zinc finger protein GLIS2 http://www.genome.jp/dbget-bin/www_bget?ko:K09233 Q7K0S9 626 1.0e-63 Zinc finger protein GLIS2 homolog OS=Drosophila melanogaster GN=sug PE=2 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.17519 BF_2 2.00 0.93 375 242003361 XP_002422710.1 184 1.1e-11 Lipase 3 precursor, putative [Pediculus humanus corporis]>gi|212505532|gb|EEB09972.1| Lipase 3 precursor, putative [Pediculus humanus corporis] -- -- -- -- -- K14452 LIPF gastric triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14452 Q9CPP7 171 1.5e-11 Gastric triacylglycerol lipase OS=Mus musculus GN=Lipf PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.17523 BF_2 1.00 19.65 217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17526 BF_2 20.55 0.68 1551 642932834 XP_008197005.1 1294 9.0e-140 PREDICTED: uncharacterized protein LOC663161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17527 BF_2 106.00 3.31 1626 270004026 EFA00474.1 825 2.3e-85 hypothetical protein TcasGA2_TC003333 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 442 2.4e-42 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.17528 BF_2 10.95 0.62 1023 270012485 EFA08933.1 481 1.1e-45 hypothetical protein TcasGA2_TC006640 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04690 YABBY protein GO:0007275 multicellular organismal development -- -- -- -- -- -- Cluster-8309.17530 BF_2 233.00 9.28 1338 572310259 XP_006620896.1 208 6.6e-14 PREDICTED: chaoptin-like isoform X1 [Apis dorsata] -- -- -- -- -- -- -- -- -- Q6P1C6 162 5.9e-10 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Mus musculus GN=Lrig3 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17531 BF_2 19.11 0.38 2375 549150205 BAO01154.1 2083 4.5e-231 broad-complex [Psacothea hilaris] 549150204 AB858991.1 1119 0 Psacothea hilaris PhBR-C_Z3 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q01295 609 1.5e-61 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651//PF13912//PF13465//PF00096 BTB/POZ domain//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- -- -- Cluster-8309.17540 BF_2 116.55 0.57 8908 642917872 XP_969181.2 2653 1.3e-296 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F3V0 345 2.4e-30 SET and MYND domain-containing protein 4 OS=Gallus gallus GN=SMYD4 PE=2 SV=1 PF13414//PF01233//PF00856//PF13181 TPR repeat//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//SET domain//Tetratricopeptide repeat GO:0042967 acyl-carrier-protein biosynthetic process GO:0008270//GO:0004379//GO:0005515 zinc ion binding//glycylpeptide N-tetradecanoyltransferase activity//protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.17544 BF_2 101.44 2.79 1810 642927984 XP_008195472.1 358 3.6e-31 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17545 BF_2 3.00 0.32 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17547 BF_2 105.00 5.06 1156 546680922 ERL91096.1 898 5.6e-94 hypothetical protein D910_08438 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBS1 331 1.3e-29 Metaxin-1 OS=Bos taurus GN=MTX1 PE=2 SV=1 PF10568 Outer mitochondrial membrane transport complex protein GO:0006626 protein targeting to mitochondrion -- -- GO:0005741 mitochondrial outer membrane KOG3028 Translocase of outer mitochondrial membrane complex, subunit TOM37/Metaxin 1 Cluster-8309.17549 BF_2 77.57 1.44 2534 478251577 ENN72039.1 659 6.3e-66 hypothetical protein YQE_11327, partial [Dendroctonus ponderosae] -- -- -- -- -- K00798 MMAB, pduO cob(I)alamin adenosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00798 Q96EY8 328 6.3e-29 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial OS=Homo sapiens GN=MMAB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17553 BF_2 28.61 1.99 888 270016876 EFA13322.1 591 1.7e-58 hypothetical protein TcasGA2_TC006845 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17556 BF_2 72.65 1.03 3235 385199932 AFI45014.1 1346 1.8e-145 cytochrome P450 CYP411a1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P29981 654 1.3e-66 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.17558 BF_2 1.22 0.32 446 270009705 EFA06153.1 206 3.7e-14 hypothetical protein TcasGA2_TC008998 [Tribolium castaneum] -- -- -- -- -- K14944 NOVA RNA-binding protein Nova http://www.genome.jp/dbget-bin/www_bget?ko:K14944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1756 BF_2 6.00 0.43 869 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17561 BF_2 4.00 0.36 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17569 BF_2 22.00 1.32 986 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04625 DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213 structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region -- -- Cluster-8309.17570 BF_2 19.00 0.39 2330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17571 BF_2 204.73 1.65 5480 270003811 EFA00259.1 2983 0.0e+00 hypothetical protein TcasGA2_TC003092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.4e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.17577 BF_2 3.01 0.48 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17579 BF_2 21.00 1.81 772 553832086 AGY61455.1 189 6.1e-12 ATP synthase CF0 C chain [Lotharella sp. CCMP622] 761231605 KM881639.1 772 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q0ZJ33 205 3.5e-15 ATP synthase subunit c, chloroplastic OS=Vitis vinifera GN=atpH PE=3 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain -- -- Cluster-8309.17582 BF_2 152.96 12.36 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17584 BF_2 79.62 1.92 2020 91094273 XP_970483.1 609 3.2e-60 PREDICTED: ethylmalonyl-CoA decarboxylase [Tribolium castaneum]>gi|270014393|gb|EFA10841.1| hypothetical protein TcasGA2_TC001618 [Tribolium castaneum] -- -- -- -- -- K18426 ECHDC1 ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18426 F1NB38 391 2.5e-36 Ethylmalonyl-CoA decarboxylase OS=Gallus gallus GN=ECHDC1 PE=3 SV=2 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0003824//GO:0016836 catalytic activity//hydro-lyase activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.17589 BF_2 6.32 0.55 767 642938276 XP_008192705.1 205 8.4e-14 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X1 [Tribolium castaneum] 642938277 XM_008194490.1 135 3.02249e-62 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17590 BF_2 312.72 10.20 1570 170028910 XP_001842337.1 905 1.2e-94 cathepsin L [Culex quinquefasciatus]>gi|167879387|gb|EDS42770.1| cathepsin L [Culex quinquefasciatus] -- -- -- -- -- K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 834 8.2e-88 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF08127//PF03051//PF00112 Peptidase family C1 propeptide//Peptidase C1-like family//Papain family cysteine protease GO:0050790//GO:0006508 regulation of catalytic activity//proteolysis GO:0004197//GO:0008233//GO:0008234 cysteine-type endopeptidase activity//peptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.17591 BF_2 150.51 1.64 4137 91079786 XP_967971.1 1583 7.4e-173 PREDICTED: probable RNA 3'-terminal phosphate cyclase-like protein [Tribolium castaneum]>gi|270003310|gb|EEZ99757.1| hypothetical protein TcasGA2_TC002529 [Tribolium castaneum] -- -- -- -- -- K11108 RCL1 RNA 3'-terminal phosphate cyclase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11108 P56175 1165 9.0e-126 Probable RNA 3'-terminal phosphate cyclase-like protein OS=Drosophila melanogaster GN=Rtc1 PE=2 SV=3 PF01607 Chitin binding Peritrophin-A domain GO:0006396//GO:0042254//GO:0006030 RNA processing//ribosome biogenesis//chitin metabolic process GO:0008061//GO:0003824 chitin binding//catalytic activity GO:0005730//GO:0005576 nucleolus//extracellular region KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.17592 BF_2 5.00 0.65 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17593 BF_2 75.61 0.91 3761 193690583 XP_001944447.1 418 8.3e-38 PREDICTED: caspase-1-like [Acyrthosiphon pisum] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 369 1.6e-33 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.17605 BF_2 20.61 0.48 2101 642935034 XP_008199914.1 150 5.5e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 198 8.1049e-97 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF03938//PF04111//PF05835//PF02841//PF10186 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Synaphin protein//Guanylate-binding protein, C-terminal domain//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006914//GO:0010508//GO:0006836 autophagy//positive regulation of autophagy//neurotransmitter transport GO:0019905//GO:0003924//GO:0005525//GO:0051082 syntaxin binding//GTPase activity//GTP binding//unfolded protein binding -- -- -- -- Cluster-8309.17608 BF_2 15.67 0.32 2321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17616 BF_2 19.00 0.66 1485 -- -- -- -- -- 761231605 KM881639.1 1482 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- A1E9U3 183 2.4e-12 Cytochrome b6-f complex subunit 5 OS=Sorghum bicolor GN=petG PE=3 SV=1 PF02529//PF05115//PF01701 Cytochrome B6-F complex subunit 5//Cytochrome B6-F complex subunit VI (PetL)//Photosystem I reaction centre subunit IX / PsaJ GO:0015979//GO:0006118 photosynthesis//obsolete electron transport GO:0009055 electron carrier activity GO:0009512//GO:0009522 cytochrome b6f complex//photosystem I -- -- Cluster-8309.17619 BF_2 20.82 0.42 2384 91090196 XP_967193.1 1568 2.3e-171 PREDICTED: cyclin-G-associated kinase [Tribolium castaneum]>gi|270013468|gb|EFA09916.1| hypothetical protein TcasGA2_TC012067 [Tribolium castaneum] -- -- -- -- -- K08855 GAK cyclin G-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08855 P97874 392 2.2e-36 Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=2 SV=1 -- -- -- -- GO:0005488//GO:0016301 binding//kinase activity -- -- KOG0431 Auxilin-like protein and related proteins containing DnaJ domain Cluster-8309.17623 BF_2 2.00 1.10 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17625 BF_2 289.36 3.18 4089 642915469 XP_008190632.1 1964 4.8e-217 PREDICTED: TBC1 domain family member 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2M4 995 4.6e-106 TBC1 domain family member 14 OS=Homo sapiens GN=TBC1D14 PE=1 SV=3 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2223 Uncharacterized conserved protein, contains TBC domain Cluster-8309.17626 BF_2 72.47 0.81 4034 642915469 XP_008190632.1 1964 4.8e-217 PREDICTED: TBC1 domain family member 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2M4 995 4.5e-106 TBC1 domain family member 14 OS=Homo sapiens GN=TBC1D14 PE=1 SV=3 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2223 Uncharacterized conserved protein, contains TBC domain Cluster-8309.17628 BF_2 2.00 2.98 298 -- -- -- -- -- 197260765 EU930255.1 38 9.13368e-09 Simulium vittatum clone SV-271 60S ribosomal protein L35 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17630 BF_2 2.00 0.34 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16113 Enoyl-CoA hydratase/isomerase -- -- GO:0016836 hydro-lyase activity -- -- -- -- Cluster-8309.17631 BF_2 60.00 2.93 1144 546685307 ERL94834.1 802 7.5e-83 hypothetical protein D910_12107 [Dendroctonus ponderosae] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q02157 410 8.7e-39 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17634 BF_2 41.54 1.88 1213 642920389 XP_008192326.1 233 7.6e-17 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17635 BF_2 55.80 0.80 3216 91092858 XP_969365.1 1314 9.0e-142 PREDICTED: probable ATP-dependent RNA helicase Dbp73D [Tribolium castaneum]>gi|270003080|gb|EEZ99527.1| hypothetical protein TcasGA2_TC000109 [Tribolium castaneum] -- -- -- -- -- K14807 DDX51, DBP6 ATP-dependent RNA helicase DDX51/DBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K14807 P26802 732 1.1e-75 Probable ATP-dependent RNA helicase Dbp73D OS=Drosophila melanogaster GN=Dbp73D PE=2 SV=3 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0097159//GO:0005524//GO:1901363//GO:0003677//GO:0016787//GO:0003676 organic cyclic compound binding//ATP binding//heterocyclic compound binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0350 DEAD-box ATP-dependent RNA helicase Cluster-8309.17636 BF_2 48.02 0.47 4585 270005292 EFA01740.1 2207 3.6e-245 hypothetical protein TcasGA2_TC007336 [Tribolium castaneum] 817199620 XM_012420083.1 130 1.12821e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q6P116 879 1.5e-92 REST corepressor 2 OS=Danio rerio GN=rcor2 PE=2 SV=1 PF04977//PF00320//PF00376 Septum formation initiator//GATA zinc finger//MerR family regulatory protein GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.17640 BF_2 33.00 0.80 2007 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17647 BF_2 95.41 5.32 1038 270001010 EEZ97457.1 1273 1.6e-137 hypothetical protein TcasGA2_TC011288 [Tribolium castaneum] 551486143 XM_005794597.1 64 1.21808e-22 PREDICTED: Xiphophorus maculatus calcium-activated potassium channel subunit alpha-1-like (LOC102225404), transcript variant X3, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1158 1.5e-125 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.17648 BF_2 3.00 1.12 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17654 BF_2 17.16 0.32 2508 449139004 AGE89831.1 657 1.1e-65 isoprenyl diphosphate synthase [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- P08836 482 8.6e-47 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.17655 BF_2 13.69 0.39 1761 546673768 ERL85319.1 1280 4.3e-138 hypothetical protein D910_02739 [Dendroctonus ponderosae] 462282558 APGK01057257.1 55 2.10824e-17 Dendroctonus ponderosae Seq01057267, whole genome shotgun sequence -- -- -- -- Q9D9I4 693 2.1e-71 TBC1 domain family member 20 OS=Mus musculus GN=Tbc1d20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2595 Predicted GTPase activator protein Cluster-8309.17660 BF_2 200.43 2.46 3701 642933135 XP_973578.2 3493 0.0e+00 PREDICTED: DNA topoisomerase 3-alpha [Tribolium castaneum] 571572814 XM_394050.5 155 1.15113e-72 PREDICTED: Apis mellifera DNA topoisomerase 3-alpha-like (LOC410571), mRNA K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 Q9NG98 2222 2.2e-248 DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 PF16588//PF06839//PF01396//PF00098//PF01022//PF00556//PF01131 C2H2 zinc-finger//GRF zinc finger//Topoisomerase DNA binding C4 zinc finger//Zinc knuckle//Bacterial regulatory protein, arsR family//Antenna complex alpha/beta subunit//DNA topoisomerase GO:0006118//GO:0006355//GO:0019684//GO:0006265 obsolete electron transport//regulation of transcription, DNA-templated//photosynthesis, light reaction//DNA topological change GO:0008270//GO:0003676//GO:0003700//GO:0003677//GO:0003916//GO:0045156 zinc ion binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//DNA binding//DNA topoisomerase activity//electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0005694//GO:0016021//GO:0005667//GO:0030077 chromosome//integral component of membrane//transcription factor complex//plasma membrane light-harvesting complex KOG1956 DNA topoisomerase III alpha Cluster-8309.17666 BF_2 143.64 4.91 1511 91083575 XP_968060.1 1166 6.1e-125 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q28GD9 376 1.0e-34 Ribonuclease H2 subunit B OS=Xenopus tropicalis GN=rnaseh2b PE=2 SV=1 PF09468 Ydr279p protein family (RNase H2 complex component) -- -- -- -- GO:0005634 nucleus KOG4705 Uncharacterized conserved protein Cluster-8309.17667 BF_2 382.20 23.28 974 31235339 XP_319221.1 1051 8.5e-112 AGAP010064-PA [Anopheles gambiae str. PEST]>gi|157128329|ref|XP_001661404.1| AAEL011087-PA [Aedes aegypti]>gi|170059825|ref|XP_001865530.1| DNA-directed RNA polymerase II 23 kDa polypeptide [Culex quinquefasciatus]>gi|30174740|gb|EAA43596.1| AGAP010064-PA [Anopheles gambiae str. PEST]>gi|108872649|gb|EAT36874.1| AAEL011087-PA [Aedes aegypti]>gi|167878475|gb|EDS41858.1| DNA-directed RNA polymerase II 23 kDa polypeptide [Culex quinquefasciatus]>gi|668456857|gb|KFB44941.1| AGAP010064-PA-like protein [Anopheles sinensis] 805824078 XM_003708039.2 240 1.65657e-120 PREDICTED: Megachile rotundata DNA-directed RNA polymerases I, II, and III subunit RPABC1 (LOC100882861), mRNA K03013 RPB5, POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03013 Q5R587 939 3.4e-100 DNA-directed RNA polymerases I, II, and III subunit RPABC1 OS=Pongo abelii GN=POLR2E PE=2 SV=1 PF03871//PF01191 RNA polymerase Rpb5, N-terminal domain//RNA polymerase Rpb5, C-terminal domain GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus KOG3218 RNA polymerase, 25-kDa subunit (common to polymerases I, II and III) Cluster-8309.17671 BF_2 15.00 5.36 403 169409580 ACA57922.1 388 2.6e-35 lactation elevated 1 (predicted) [Callicebus moloch] 20145318 AL627442.10 294 6.25152e-151 Human DNA sequence from clone RP11-296E3 on chromosome 1, complete sequence -- -- -- -- Q9UN81 283 1.6e-24 LINE-1 retrotransposable element ORF1 protein OS=Homo sapiens GN=L1RE1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17673 BF_2 7.86 1.00 615 270013391 EFA09839.1 971 1.0e-102 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 146 1.9e-08 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17678 BF_2 15.78 0.95 984 270002027 EEZ98474.1 286 4.4e-23 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02176 TRAF-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.1768 BF_2 3.00 0.95 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17680 BF_2 46.00 1.28 1795 195446244 XP_002070694.1 969 5.1e-102 GK10887 [Drosophila willistoni]>gi|194166779|gb|EDW81680.1| GK10887 [Drosophila willistoni] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q96K12 775 6.5e-81 Fatty acyl-CoA reductase 2 OS=Homo sapiens GN=FAR2 PE=2 SV=1 PF03015//PF01370//PF01073//PF01118 Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process GO:0080019//GO:0016620//GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.17682 BF_2 68.75 3.47 1116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17685 BF_2 4.00 0.33 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17686 BF_2 54.00 1.26 2076 831786006 XP_012757968.1 987 4.8e-104 hypothetical protein SAMD00019534_019230 [Acytostelium subglobosum LB1]>gi|735858600|dbj|GAM18748.1| hypothetical protein SAMD00019534_019230 [Acytostelium subglobosum LB1] 13195429 AF327055.1 1948 0 AF327055 Oryza sativa alpha 1,4-glucan phosphorylase L isozyme mRNA, partial cds K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P27598 1746 1.9e-193 Alpha-1,4 glucan phosphorylase L isozyme, chloroplastic/amyloplastic OS=Ipomoea batatas PE=2 SV=1 PF00343//PF01213 Carbohydrate phosphorylase//Adenylate cyclase associated (CAP) N terminal GO:0005975//GO:0007010 carbohydrate metabolic process//cytoskeleton organization GO:0003779//GO:0008184 actin binding//glycogen phosphorylase activity -- -- KOG2099 Glycogen phosphorylase Cluster-8309.17687 BF_2 24.16 0.73 1665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02077 SURF4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17689 BF_2 18.87 0.34 2601 546684308 ERL94013.1 983 1.7e-103 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- K15446 TRM13, CCDC76 tRNA:m4X modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15446 Q9NUP7 494 3.6e-48 tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens GN=TRMT13 PE=1 SV=2 PF02077//PF11722//PF05206 SURF4 family//CCCH zinc finger in TRM13 protein//Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity GO:0016021 integral component of membrane KOG2811 Uncharacterized conserved protein Cluster-8309.17690 BF_2 42.22 0.76 2598 546684308 ERL94013.1 1221 4.4e-131 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- K15446 TRM13, CCDC76 tRNA:m4X modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15446 Q9NUP7 655 7.8e-67 tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens GN=TRMT13 PE=1 SV=2 PF02077//PF11722//PF05206 SURF4 family//CCCH zinc finger in TRM13 protein//Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity GO:0016021 integral component of membrane KOG2811 Uncharacterized conserved protein Cluster-8309.17699 BF_2 15.33 0.34 2185 642933131 XP_008197270.1 655 1.6e-65 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 1.9875e-33 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 372 4.3e-34 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1770 BF_2 26.71 3.01 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17702 BF_2 3.00 0.42 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17703 BF_2 4.15 0.51 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17706 BF_2 43.48 4.15 725 584482886 AHJ09940.1 1022 1.5e-108 glycoside hydrolase family 28 [Apriona japonica] 584482885 KF724642.1 603 0 Apriona japonica glycoside hydrolase family 28 (gh28-2) mRNA, complete cds -- -- -- -- A2R8F8 430 2.7e-41 Probable endopolygalacturonase A OS=Aspergillus niger (strain CBS 513.88 / FGSC A1513) GN=pgaA PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.17707 BF_2 87.12 2.98 1512 748995298 AJE75671.1 1213 2.2e-130 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09849 954 9.6e-102 Lactase-phlorizin hydrolase OS=Oryctolagus cuniculus GN=LCT PE=1 SV=1 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.17708 BF_2 33.79 1.26 1409 748995278 AJE75661.1 1144 2.0e-122 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q02401 862 4.2e-91 Lactase-phlorizin hydrolase OS=Rattus norvegicus GN=Lct PE=2 SV=2 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.17709 BF_2 232.66 6.17 1865 91077926 XP_974115.1 793 1.3e-81 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9X248 307 1.3e-26 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=fabG PE=3 SV=1 PF02826//PF02076//PF12242//PF01370//PF00106 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Pheromone A receptor//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152//GO:0007606//GO:0019236//GO:0055114//GO:0007186 metabolic process//sensory perception of chemical stimulus//response to pheromone//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0016491//GO:0051287//GO:0050662//GO:0003824//GO:0004932 oxidoreductase activity//NAD binding//coenzyme binding//catalytic activity//mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.1771 BF_2 19.29 1.62 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17712 BF_2 85.15 1.57 2562 189240519 XP_971298.2 1682 1.5e-184 PREDICTED: RING finger protein unkempt [Tribolium castaneum] 641657988 XM_008182333.1 256 5.67807e-129 PREDICTED: Acyrthosiphon pisum RING finger protein unkempt (LOC100161020), mRNA -- -- -- -- Q86B79 1434 3.6e-157 RING finger protein unkempt OS=Drosophila melanogaster GN=unk PE=1 SV=1 PF01486//PF00642 K-box region//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003700 metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1595 CCCH-type Zn-finger protein Cluster-8309.17713 BF_2 15.85 0.33 2278 270012593 EFA09041.1 1077 1.9e-114 hypothetical protein TcasGA2_TC006754 [Tribolium castaneum] 462333338 APGK01039007.1 138 1.9873e-63 Dendroctonus ponderosae Seq01039017, whole genome shotgun sequence -- -- -- -- Q86B79 628 9.2e-64 RING finger protein unkempt OS=Drosophila melanogaster GN=unk PE=1 SV=1 PF01486//PF00642//PF08988 K-box region//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Type III secretion system, cytoplasmic E component of needle GO:0009405//GO:0006355 pathogenesis//regulation of transcription, DNA-templated GO:0046872//GO:0003700 metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1595 CCCH-type Zn-finger protein Cluster-8309.17716 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17717 BF_2 13.00 0.62 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17720 BF_2 300.47 3.98 3449 91081763 XP_973188.1 1361 3.4e-147 PREDICTED: UDP-glucuronosyltransferase 2B20 [Tribolium castaneum]>gi|270005052|gb|EFA01500.1| hypothetical protein TcasGA2_TC007056 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O77649 527 7.2e-52 UDP-glucuronosyltransferase 2B20 OS=Macaca fascicularis GN=UGT2B20 PE=1 SV=1 PF00201//PF00641//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Zn-finger in Ran binding protein and others//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758//GO:0008270//GO:0016740 transferase activity, transferring hexosyl groups//zinc ion binding//transferase activity -- -- -- -- Cluster-8309.17722 BF_2 2.00 5.31 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17723 BF_2 11.00 0.87 819 752872963 XP_011253745.1 395 8.4e-36 PREDICTED: lipase 3-like isoform X1 [Camponotus floridanus]>gi|307183093|gb|EFN70010.1| Lipase 3 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- O46108 322 1.0e-28 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17724 BF_2 7.00 1.05 567 328700272 XP_003241200.1 461 1.3e-43 PREDICTED: gastric triacylglycerol lipase-like [Acyrthosiphon pisum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46107 387 2.0e-36 Lipase 1 OS=Drosophila melanogaster GN=Lip1 PE=2 SV=2 PF01074//PF04083 Glycosyl hydrolases family 38 N-terminal domain//Partial alpha/beta-hydrolase lipase region GO:0005975//GO:0006629 carbohydrate metabolic process//lipid metabolic process GO:0004559 alpha-mannosidase activity -- -- -- -- Cluster-8309.17729 BF_2 2.00 0.79 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17735 BF_2 14.41 1.28 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17736 BF_2 14.60 0.85 1007 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17739 BF_2 19.12 0.73 1381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17741 BF_2 381.01 25.35 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17745 BF_2 26.00 3.26 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17747 BF_2 193.32 3.31 2728 828235266 XP_012566344.1 1182 1.5e-126 PREDICTED: tigger transposable element-derived protein 1-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08671//PF04218//PF05225//PF03184//PF02232 Anti-repressor SinI//CENP-B N-terminal DNA-binding domain//helix-turn-helix, Psq domain//DDE superfamily endonuclease//Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676//GO:0046983 DNA binding//nucleic acid binding//protein dimerization activity -- -- -- -- Cluster-8309.1775 BF_2 26.00 1.85 874 478254053 ENN74345.1 158 2.7e-08 hypothetical protein YQE_09315, partial [Dendroctonus ponderosae]>gi|546672816|gb|ERL84572.1| hypothetical protein D910_02001 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05221 S-adenosyl-L-homocysteine hydrolase GO:0006555//GO:0006730 methionine metabolic process//one-carbon metabolic process GO:0004013 adenosylhomocysteinase activity -- -- -- -- Cluster-8309.17753 BF_2 187.73 1.88 4461 221115973 XP_002165005.1 962 8.2e-101 PREDICTED: uncharacterized protein LOC100209733 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- Q52V16 273 2.6e-22 Zinc finger Y-chromosomal protein OS=Gorilla gorilla gorilla GN=ZFY PE=3 SV=1 PF03184//PF02150//PF06397//PF13465//PF00096 DDE superfamily endonuclease//RNA polymerases M/15 Kd subunit//Desulfoferrodoxin, N-terminal domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0005506//GO:0003676 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//iron ion binding//nucleic acid binding GO:0005730 nucleolus -- -- Cluster-8309.17760 BF_2 67.62 0.34 8515 546681932 ERL91928.1 3803 0.0e+00 hypothetical protein D910_09251 [Dendroctonus ponderosae] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.2e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF02257//PF06119//PF07645//PF00008 RFX DNA-binding domain//Nidogen-like//Calcium-binding EGF domain//EGF-like domain GO:0006355//GO:0007160 regulation of transcription, DNA-templated//cell-matrix adhesion GO:0005515//GO:0005509//GO:0003677 protein binding//calcium ion binding//DNA binding -- -- KOG1214 Nidogen and related basement membrane protein proteins Cluster-8309.17761 BF_2 54.85 1.93 1479 642924737 XP_008194418.1 941 7.4e-99 PREDICTED: protein-S-isoprenylcysteine O-methyltransferase [Tribolium castaneum]>gi|270006711|gb|EFA03159.1| hypothetical protein TcasGA2_TC013078 [Tribolium castaneum] 242016078 XM_002428618.1 45 6.38875e-12 Pediculus humanus corporis protein-S-isoprenylcysteine O-methyltransferase, putative, mRNA K00587 ICMT, STE14 protein-S-isoprenylcysteine O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00587 O12947 691 3.0e-71 Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 PF00951//PF09174//PF04140 Arterivirus GL envelope glycoprotein//Maf1 regulator//Isoprenylcysteine carboxyl methyltransferase (ICMT) family GO:0006479//GO:0006481//GO:0016480 protein methylation//C-terminal protein methylation//negative regulation of transcription from RNA polymerase III promoter GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021//GO:0005783//GO:0019031 integral component of membrane//endoplasmic reticulum//viral envelope KOG2628 Farnesyl cysteine-carboxyl methyltransferase Cluster-8309.17766 BF_2 282.76 4.12 3158 642911198 XP_008199568.1 4027 0.0e+00 PREDICTED: solute carrier family 12 member 4 isoform X2 [Tribolium castaneum] 768953561 XM_011617286.1 47 1.06746e-12 PREDICTED: Takifugu rubripes solute carrier family 12 (potassium/chloride transporter), member 6 (slc12a6), mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2705 1.8e-304 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006810//GO:0006811//GO:0055085 transport//ion transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.17767 BF_2 13.68 0.82 989 91078614 XP_967493.1 641 3.0e-64 PREDICTED: syntaxin-6 [Tribolium castaneum] 642915693 XM_962400.2 38 3.29054e-08 PREDICTED: Tribolium castaneum syntaxin 6 (LOC655837), mRNA K08498 STX6 syntaxin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08498 Q5R6Q2 279 1.2e-23 Syntaxin-6 OS=Pongo abelii GN=STX6 PE=2 SV=1 PF05739//PF00523//PF00957//PF05478 SNARE domain//Fusion glycoprotein F0//Synaptobrevin//Prominin GO:0006948//GO:0016192 induction by virus of host cell-cell fusion//vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.17774 BF_2 38.00 0.67 2654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04189 Gcd10p family GO:0030488 tRNA methylation -- -- GO:0031515 tRNA (m1A) methyltransferase complex -- -- Cluster-8309.17776 BF_2 89.42 1.68 2520 642920946 XP_008192625.1 2432 1.6e-271 PREDICTED: amyloid beta A4 precursor protein-binding family B member 2-like isoform X3 [Tribolium castaneum]>gi|270006137|gb|EFA02585.1| hypothetical protein TcasGA2_TC008304 [Tribolium castaneum] -- -- -- -- -- K04530 APBB2, FE65L amyloid beta (A4) precursor protein-binding, family B, member 2 (Fe65-like) http://www.genome.jp/dbget-bin/www_bget?ko:K04530 Q9DBR4 789 2.2e-82 Amyloid beta A4 precursor protein-binding family B member 2 OS=Mus musculus GN=Apbb2 PE=1 SV=2 PF00397//PF00640//PF08416 WW domain//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.17778 BF_2 8.00 0.78 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17780 BF_2 378.30 12.94 1510 332373106 AEE61694.1 1523 2.5e-166 unknown [Dendroctonus ponderosae]>gi|478251663|gb|ENN72117.1| hypothetical protein YQE_11176, partial [Dendroctonus ponderosae]>gi|478262744|gb|ENN81275.1| hypothetical protein YQE_02311, partial [Dendroctonus ponderosae]>gi|546680917|gb|ERL91091.1| hypothetical protein D910_08433 [Dendroctonus ponderosae] 66823846 XM_640186.1 221 9.47938e-110 Dictyostelium discoideum AX4 protein phosphatase 6 catalytic subunit (ppp6C) mRNA, complete cds K15498 PPP6C serine/threonine-protein phosphatase 6 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15498 Q64620 1374 1.9e-150 Serine/threonine-protein phosphatase 6 catalytic subunit OS=Rattus norvegicus GN=Ppp6c PE=2 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0373 Serine/threonine specific protein phosphatase involved in cell cycle control, PP2A-related Cluster-8309.17783 BF_2 87.83 2.49 1763 270015414 EFA11862.1 731 2.0e-74 hypothetical protein TcasGA2_TC005104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17785 BF_2 8.00 0.55 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17795 BF_2 5.00 6.72 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17797 BF_2 26.00 0.37 3244 158262721 NP_001103418.1 2344 3.3e-261 nicotinic acetylcholine receptor beta 1 subunit isoform 1 precursor [Tribolium castaneum]>gi|154810995|gb|ABS86916.1| nicotinic acetylcholine receptor subunit beta1 [Tribolium castaneum]>gi|270015608|gb|EFA12056.1| nicotinic acetylcholine receptor subunit beta1 [Tribolium castaneum] 807015737 XM_012301063.1 344 8.68486e-178 PREDICTED: Ceratitis capitata acetylcholine receptor subunit beta-like 1 (LOC101461364), mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P04755 2181 1.1e-243 Acetylcholine receptor subunit beta-like 1 OS=Drosophila melanogaster GN=nAChRbeta1 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006812//GO:0006810//GO:0007165 ion transport//cation transport//transport//signal transduction GO:0005230//GO:0004889 extracellular ligand-gated ion channel activity//acetylcholine-activated cation-selective channel activity GO:0045211//GO:0030054//GO:0016020//GO:0016021//GO:0005886 postsynaptic membrane//cell junction//membrane//integral component of membrane//plasma membrane KOG3645 Acetylcholine receptor Cluster-8309.17798 BF_2 396.62 8.48 2243 642927459 XP_968905.2 1040 3.7e-110 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q3SZJ4 752 3.8e-78 Prostaglandin reductase 1 OS=Bos taurus GN=PTGR1 PE=2 SV=1 PF01370//PF00106//PF01118//PF02826//PF00107 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0051287//GO:0016491//GO:0016620//GO:0003824//GO:0050662 NAD binding//oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.17805 BF_2 343.86 29.91 768 290909033 ADD70031.1 362 5.3e-32 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- P54193 143 5.4e-08 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.17810 BF_2 8.04 0.67 793 642935524 XP_008198045.1 307 1.3e-25 PREDICTED: casein kinase I isoform alpha isoform X3 [Tribolium castaneum] 240957921 XM_002400117.1 122 5.27427e-55 Ixodes scapularis casein kinase, putative, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67829 292 2.9e-25 Casein kinase I isoform alpha OS=Ovis aries GN=CSNK1A1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1163 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.17811 BF_2 2.00 0.35 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17813 BF_2 109.32 0.60 7915 170286893 BAG13448.1 5658 0.0e+00 chitinase [Monochamus alternatus] 170286892 AB428669.1 3476 0 Monochamus alternatus MaChiPm1 mRNA for chitinase, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W5U2 1545 1.5e-169 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607//PF00704//PF03970 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Herpesvirus UL37 tegument protein GO:0019068//GO:0005975//GO:0006030 virion assembly//carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region -- -- Cluster-8309.17815 BF_2 68.86 1.14 2807 91088573 XP_973123.1 1442 1.1e-156 PREDICTED: ubiA prenyltransferase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270012242|gb|EFA08690.1| hypothetical protein TcasGA2_TC006361 [Tribolium castaneum] 642931909 XM_968030.2 316 2.756e-162 PREDICTED: Tribolium castaneum ubiA prenyltransferase domain-containing protein 1 homolog (LOC661899), mRNA -- -- -- -- Q9V3R8 1086 8.8e-117 UbiA prenyltransferase domain-containing protein 1 homolog OS=Drosophila melanogaster GN=heix PE=2 SV=1 PF01496//PF15812//PF16326//PF04977//PF06009//PF05531//PF07851//PF04513//PF02601//PF17078//PF08912//PF06305//PF03462//PF01040//PF00804//PF04111//PF03255//PF03965 V-type ATPase 116kDa subunit family//Melanoregulin//ABC transporter C-terminal domain//Septum formation initiator//Laminin Domain II//Nucleopolyhedrovirus P10 protein//TMPIT-like protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//SWI5-dependent HO expression protein 3//Rho Binding//Protein of unknown function (DUF1049)//PCRF domain//UbiA prenyltransferase family//Syntaxin//Autophagy protein Apg6//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Penicillinase repressor GO:0006308//GO:0007155//GO:0015991//GO:0006449//GO:0007049//GO:0045892//GO:0006914//GO:0032402//GO:0051028//GO:0048309//GO:0006633//GO:0015992//GO:0006415//GO:0006090 DNA catabolic process//cell adhesion//ATP hydrolysis coupled proton transport//regulation of translational termination//cell cycle//negative regulation of transcription, DNA-templated//autophagy//melanosome transport//mRNA transport//endoplasmic reticulum inheritance//fatty acid biosynthetic process//proton transport//translational termination//pyruvate metabolic process GO:0008855//GO:0016149//GO:0003677//GO:0015078//GO:0005198//GO:0004659//GO:0003989//GO:0017048 exodeoxyribonuclease VII activity//translation release factor activity, codon specific//DNA binding//hydrogen ion transmembrane transporter activity//structural molecule activity//prenyltransferase activity//acetyl-CoA carboxylase activity//Rho GTPase binding GO:0033179//GO:0016020//GO:0019031//GO:0009317//GO:0005737//GO:0005840//GO:0016021//GO:0005887//GO:0042470//GO:0018444//GO:0009318//GO:0019028 proton-transporting V-type ATPase, V0 domain//membrane//viral envelope//acetyl-CoA carboxylase complex//cytoplasm//ribosome//integral component of membrane//integral component of plasma membrane//melanosome//translation release factor complex//exodeoxyribonuclease VII complex//viral capsid KOG3433 Protein involved in meiotic recombination/predicted coiled-coil protein Cluster-8309.17818 BF_2 507.59 7.00 3321 91088573 XP_973123.1 1442 1.3e-156 PREDICTED: ubiA prenyltransferase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270012242|gb|EFA08690.1| hypothetical protein TcasGA2_TC006361 [Tribolium castaneum] 642931909 XM_968030.2 316 3.26722e-162 PREDICTED: Tribolium castaneum ubiA prenyltransferase domain-containing protein 1 homolog (LOC661899), mRNA -- -- -- -- Q9V3R8 1086 1.0e-116 UbiA prenyltransferase domain-containing protein 1 homolog OS=Drosophila melanogaster GN=heix PE=2 SV=1 PF01040//PF06331 UbiA prenyltransferase family//Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated GO:0004659 prenyltransferase activity GO:0000439//GO:0016021 core TFIIH complex//integral component of membrane KOG3362 Predicted BBOX Zn-finger protein Cluster-8309.17819 BF_2 79.99 1.93 2018 642918952 XP_974118.3 1514 3.6e-165 PREDICTED: protein king tubby [Tribolium castaneum]>gi|270005704|gb|EFA02152.1| hypothetical protein TcasGA2_TC007804 [Tribolium castaneum] 820849454 XM_003693782.2 230 1.26543e-114 PREDICTED: Apis florea protein king tubby (LOC100866222), mRNA -- -- -- -- Q7PZK5 976 3.6e-104 Protein king tubby OS=Anopheles gambiae GN=king-tubby PE=3 SV=4 -- -- -- -- -- -- -- -- KOG2502 Tub family proteins Cluster-8309.17826 BF_2 4.80 0.31 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03229 Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process -- -- -- -- -- -- Cluster-8309.17830 BF_2 55.16 1.17 2267 91081907 XP_970048.1 1659 6.3e-182 PREDICTED: myotubularin-related protein 9 isoform X2 [Tribolium castaneum]>gi|270007347|gb|EFA03795.1| hypothetical protein TcasGA2_TC013907 [Tribolium castaneum] -- -- -- -- -- K18084 MTMR9 myotubularin-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18084 Q96QG7 1167 2.9e-126 Myotubularin-related protein 9 OS=Homo sapiens GN=MTMR9 PE=1 SV=1 -- -- GO:0016311 dephosphorylation GO:0016791 phosphatase activity -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.17831 BF_2 270.00 6.59 2002 91077510 XP_969609.1 1304 8.1e-141 PREDICTED: microfibrillar-associated protein 1 [Tribolium castaneum]>gi|270001604|gb|EEZ98051.1| hypothetical protein TcasGA2_TC000456 [Tribolium castaneum] 642914056 XM_964516.2 278 2.60416e-141 PREDICTED: Tribolium castaneum microfibrillar-associated protein 1 (LOC658105), mRNA K13110 MFAP1 microfibrillar-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13110 P55080 695 1.4e-71 Microfibrillar-associated protein 1 OS=Gallus gallus GN=MFAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1425 Microfibrillar-associated protein MFAP1 Cluster-8309.17832 BF_2 6.00 2.13 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17833 BF_2 23.54 0.73 1636 478250641 ENN71133.1 467 7.5e-44 hypothetical protein YQE_12064, partial [Dendroctonus ponderosae]>gi|546674776|gb|ERL86073.1| hypothetical protein D910_03487 [Dendroctonus ponderosae] -- -- -- -- -- K03103 MINPP1 multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K03103 -- -- -- -- PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.17834 BF_2 11.59 0.50 1261 642912272 XP_008200632.1 224 8.7e-16 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09298 Fumarylacetoacetase N-terminal GO:0006570//GO:0042207//GO:0009072 tyrosine metabolic process//styrene catabolic process//aromatic amino acid family metabolic process GO:0004334 fumarylacetoacetase activity -- -- -- -- Cluster-8309.17838 BF_2 371.52 5.12 3323 815897996 XP_012249713.1 1799 5.3e-198 PREDICTED: histone deacetylase 6 [Bombus impatiens] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 1328 9.1e-145 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.17839 BF_2 60.00 2.71 1213 270297196 NP_001161929.1 428 1.8e-39 peritrophic matrix protein 14 precursor [Tribolium castaneum]>gi|268309046|gb|ACY95489.1| peritrophic matrix protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76217 204 7.2e-15 Peritrophin-1 OS=Anopheles gambiae GN=Aper1 PE=2 SV=2 PF01821//PF02166//PF01607 Anaphylotoxin-like domain//Androgen receptor//Chitin binding Peritrophin-A domain GO:0006355//GO:0030521//GO:0006030//GO:0007165 regulation of transcription, DNA-templated//androgen receptor signaling pathway//chitin metabolic process//signal transduction GO:0008061//GO:0005496//GO:0004882//GO:0003677 chitin binding//steroid binding//androgen receptor activity//DNA binding GO:0005576//GO:0005634 extracellular region//nucleus -- -- Cluster-8309.17844 BF_2 16.00 0.57 1454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17845 BF_2 5.00 0.59 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17846 BF_2 273.41 5.00 2574 478252154 ENN72582.1 1183 1.1e-126 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 A6H751 837 6.0e-88 Folylpolyglutamate synthase, mitochondrial OS=Bos taurus GN=FPGS PE=2 SV=1 PF08245//PF02875 Mur ligase middle domain//Mur ligase family, glutamate ligase domain GO:0009058 biosynthetic process GO:0016874//GO:0005524 ligase activity//ATP binding -- -- KOG2525 Folylpolyglutamate synthase Cluster-8309.17848 BF_2 120.20 2.26 2510 478252154 ENN72582.1 944 5.6e-99 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 699 5.9e-72 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF02023//PF08245 SCAN domain//Mur ligase middle domain GO:0009058//GO:0006355 biosynthetic process//regulation of transcription, DNA-templated GO:0003700//GO:0005524 transcription factor activity, sequence-specific DNA binding//ATP binding GO:0005667 transcription factor complex KOG2525 Folylpolyglutamate synthase Cluster-8309.17850 BF_2 127.33 2.38 2521 478252154 ENN72582.1 1192 9.9e-128 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 845 7.0e-89 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF02875//PF08245 Mur ligase family, glutamate ligase domain//Mur ligase middle domain GO:0009058 biosynthetic process GO:0005524//GO:0016874 ATP binding//ligase activity -- -- KOG2525 Folylpolyglutamate synthase Cluster-8309.17852 BF_2 4.00 4.51 312 801385089 XP_012055790.1 346 1.5e-30 PREDICTED: LOW QUALITY PROTEIN: protein H2A.5-like [Atta cephalotes] 795044337 XM_012012496.1 113 1.95314e-50 PREDICTED: Vollenhovia emeryi histone H2A (LOC105562015), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84054 346 6.3e-32 Histone H2A OS=Drosophila simulans GN=His2A PE=3 SV=2 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.17853 BF_2 35.00 1.30 1413 195356866 XP_002044858.1 482 1.2e-45 GM16910 [Drosophila sechellia]>gi|194122923|gb|EDW44966.1| GM16910 [Drosophila sechellia] 801397371 XM_012203695.1 131 9.5052e-60 PREDICTED: Atta cephalotes histone H2B (LOC105622276), mRNA K11252 H2B histone H2B http://www.genome.jp/dbget-bin/www_bget?ko:K11252 P21897 449 3.3e-43 Histone H2B OS=Chironomus thummi thummi PE=3 SV=2 PF00125//PF03847 Core histone H2A/H2B/H3/H4//Transcription initiation factor TFIID subunit A GO:0006352//GO:0006334 DNA-templated transcription, initiation//nucleosome assembly GO:0046982//GO:0003677 protein heterodimerization activity//DNA binding GO:0005669//GO:0005634//GO:0000786 transcription factor TFIID complex//nucleus//nucleosome -- -- Cluster-8309.17856 BF_2 59.79 1.02 2750 91088333 XP_970609.1 1155 2.1e-123 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 706 1.0e-72 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF15281//PF07690//PF00083 Consortin C-terminus//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0042998 transmembrane transport//positive regulation of Golgi to plasma membrane protein transport GO:0022857//GO:0071253 transmembrane transporter activity//connexin binding GO:0016021//GO:0005802 integral component of membrane//trans-Golgi network -- -- Cluster-8309.17858 BF_2 46.75 0.79 2763 91088333 XP_970609.1 821 1.1e-84 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 504 2.7e-49 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF15281//PF00083//PF07690 Consortin C-terminus//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0042998 transmembrane transport//positive regulation of Golgi to plasma membrane protein transport GO:0022857//GO:0071253 transmembrane transporter activity//connexin binding GO:0016021//GO:0005802 integral component of membrane//trans-Golgi network -- -- Cluster-8309.17859 BF_2 35.99 1.99 1043 91083631 XP_970382.1 1150 3.0e-123 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] -- -- -- -- -- K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 808 5.6e-85 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF02233//PF01752 NAD(P) transhydrogenase beta subunit//Collagenase GO:0006508//GO:0055114//GO:0015992//GO:0006769//GO:0046497 proteolysis//oxidation-reduction process//proton transport//nicotinamide metabolic process//nicotinate nucleotide metabolic process GO:0008270//GO:0004252//GO:0050661//GO:0008750 zinc ion binding//serine-type endopeptidase activity//NADP binding//NAD(P)+ transhydrogenase (AB-specific) activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.17863 BF_2 3.00 0.42 583 780638880 XP_011687487.1 169 9.5e-10 PREDICTED: uncharacterized protein LOC105449806 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17867 BF_2 4.00 3.06 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17868 BF_2 87.00 2.17 1963 556747983 XP_005969439.1 422 1.5e-38 PREDICTED: glucose-1-phosphate adenylyltransferase large subunit 2, chloroplastic-like [Pantholops hodgsonii] 169244408 EU267956.1 1845 0 Oryza sativa Japonica Group clone KCS326G03 ADP-glucose pyrophosphorylase mRNA, complete cds -- -- -- -- P55241 1993 4.2e-222 Glucose-1-phosphate adenylyltransferase large subunit 1, chloroplastic/amyloplastic OS=Zea mays GN=SH2 PE=1 SV=1 PF00483 Nucleotidyl transferase GO:0009058 biosynthetic process GO:0016779 nucleotidyltransferase activity -- -- -- -- Cluster-8309.17870 BF_2 45.50 7.19 552 820805540 AKG92761.1 203 1.0e-13 mnt2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00010//PF07448 Helix-loop-helix DNA-binding domain//Secreted phosphoprotein 24 (Spp-24) GO:0046849 bone remodeling GO:0046983 protein dimerization activity GO:0005576 extracellular region -- -- Cluster-8309.17875 BF_2 351.00 523.60 298 432116232 ELK37276.1 246 5.8e-19 hypothetical protein MDA_GLEAN10012073 [Myotis davidii] 221219022 NR_001445.2 298 2.67573e-153 Homo sapiens RNA, 7SK small nuclear (RN7SK), small nuclear RNA >gnl|BL_ORD_ID|6331544 TPA: Homo sapiens Small nuclear RNA7SK (RN7SK gene) -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17876 BF_2 147.00 4.45 1669 646712022 KDR16973.1 1438 1.9e-156 THO complex subunit 3 [Zootermopsis nevadensis] 242008837 XM_002425159.1 194 1.07265e-94 Pediculus humanus corporis THO complex subunit, putative, mRNA K12880 THOC3 THO complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12880 Q96J01 1187 1.0e-128 THO complex subunit 3 OS=Homo sapiens GN=THOC3 PE=1 SV=1 PF00400//PF00930//PF04053 WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Coatomer WD associated region GO:0006508//GO:0016192//GO:0006886 proteolysis//vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG1407 WD40 repeat protein Cluster-8309.17882 BF_2 75.00 3.75 1124 91084479 XP_971343.1 878 1.1e-91 PREDICTED: nudC domain-containing protein 3 [Tribolium castaneum]>gi|270008680|gb|EFA05128.1| hypothetical protein TcasGA2_TC015243 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB75 321 1.8e-28 NudC domain-containing protein 3 OS=Pongo abelii GN=NUDCD3 PE=2 SV=1 PF01119 DNA mismatch repair protein, C-terminal domain GO:0006298 mismatch repair GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.17885 BF_2 52.68 0.66 3626 289474532 ADC97877.1 4014 0.0e+00 ATP-binding cassette transporter [Chrysomela tremula] 729303870 XM_010529424.1 38 1.23619e-07 PREDICTED: Tarenaya hassleriana ABC transporter B family member 13-like (LOC104805021), mRNA K05658 ABCB1 ATP-binding cassette, subfamily B (MDR/TAP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05658 P21448 2424 8.1e-272 Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2 PF00503//PF00485//PF00910//PF00931//PF00005//PF03193//PF01637//PF00006//PF06414//PF00004//PF01583//PF07728//PF00664//PF13304 G-protein alpha subunit//Phosphoribulokinase / Uridine kinase family//RNA helicase//NB-ARC domain//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//ATP synthase alpha/beta family, nucleotide-binding domain//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system GO:0008152//GO:0000103//GO:0006144//GO:0055085//GO:0007165//GO:0006810//GO:0007186 metabolic process//sulfate assimilation//purine nucleobase metabolic process//transmembrane transport//signal transduction//transport//G-protein coupled receptor signaling pathway GO:0003723//GO:0004020//GO:0043531//GO:0004871//GO:0005525//GO:0003724//GO:0031683//GO:0005524//GO:0003924//GO:0019001//GO:0016887//GO:0016301//GO:0042626 RNA binding//adenylylsulfate kinase activity//ADP binding//signal transducer activity//GTP binding//RNA helicase activity//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//guanyl nucleotide binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.17886 BF_2 314.00 22.81 863 91089255 XP_969352.1 456 7.4e-43 PREDICTED: 39S ribosomal protein L12, mitochondrial [Tribolium castaneum]>gi|270011463|gb|EFA07911.1| hypothetical protein TcasGA2_TC005486 [Tribolium castaneum] -- -- -- -- -- K02935 RP-L7, MRPL12, rplL large subunit ribosomal protein L7/L12 http://www.genome.jp/dbget-bin/www_bget?ko:K02935 P52815 190 2.1e-13 39S ribosomal protein L12, mitochondrial OS=Homo sapiens GN=MRPL12 PE=1 SV=2 PF16320//PF00542 Ribosomal protein L7/L12 dimerisation domain//Ribosomal protein L7/L12 C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1715 Mitochondrial/chloroplast ribosomal protein L12 Cluster-8309.17887 BF_2 321.00 6.07 2501 270006895 EFA03343.1 1334 3.3e-144 hypothetical protein TcasGA2_TC013320 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q71RS6 622 5.0e-63 Sodium/potassium/calcium exchanger 5 OS=Homo sapiens GN=SLC24A5 PE=1 SV=1 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.17891 BF_2 38.66 1.54 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17895 BF_2 4.00 0.37 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17896 BF_2 4.00 0.37 741 795017237 XP_011858781.1 137 6.2e-06 PREDICTED: uncharacterized protein LOC105556307 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17897 BF_2 12.25 0.61 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17898 BF_2 807.00 21.45 1861 728418218 AIY68361.1 1700 9.0e-187 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01050 BCHE cholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01050 B2D0J5 590 1.9e-59 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.17903 BF_2 166.00 2.25 3380 642921085 XP_001815304.2 1420 4.8e-154 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q1LXK4 1141 4.5e-123 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF00270//PF00004//PF13361//PF00580//PF02562//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//UvrD-like helicase C-terminal domain//UvrD/REP helicase N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding -- -- KOG1804 RNA helicase Cluster-8309.17905 BF_2 14.00 1.11 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17908 BF_2 681.27 9.26 3365 642918572 XP_008199322.1 1470 7.6e-160 PREDICTED: ADP-ribosylation factor GTPase-activating protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12492 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12492 Q8N6T3 527 7.0e-52 ADP-ribosylation factor GTPase-activating protein 1 OS=Homo sapiens GN=ARFGAP1 PE=1 SV=2 PF01825//PF01412 GPCR proteolysis site, GPS, motif//Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity GO:0016020 membrane KOG0704 ADP-ribosylation factor GTPase activator Cluster-8309.17915 BF_2 6.00 1.42 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17917 BF_2 30.31 0.66 2194 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17919 BF_2 64.38 1.23 2477 189238125 XP_001814215.1 2443 8.4e-273 PREDICTED: phagocyte signaling-impaired protein [Tribolium castaneum]>gi|270008817|gb|EFA05265.1| hypothetical protein TcasGA2_TC015420 [Tribolium castaneum] 462295253 APGK01052815.1 38 8.41149e-08 Dendroctonus ponderosae Seq01052825, whole genome shotgun sequence -- -- -- -- Q17DK2 1140 4.3e-123 Phagocyte signaling-impaired protein OS=Aedes aegypti GN=psidin PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2053 Mitochondrial inheritance and actin cytoskeleton organization protein Cluster-8309.17922 BF_2 8.55 0.52 978 642915536 XP_008190656.1 507 1.0e-48 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] 571572834 XM_006565667.1 109 1.10549e-47 PREDICTED: Apis mellifera uncharacterized FAM18-like protein CG5021-like (LOC408503), transcript variant X5, mRNA -- -- -- -- Q8IQC1 430 3.6e-41 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.17923 BF_2 3.07 1.19 393 642915536 XP_008190656.1 247 5.8e-19 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IQC1 136 1.8e-07 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 -- -- -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.17925 BF_2 3.00 0.32 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17926 BF_2 31.00 1.76 1024 241669411 XP_002399632.1 501 5.3e-48 secreted protein, putative [Ixodes scapularis]>gi|215506176|gb|EEC15670.1| secreted protein, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17929 BF_2 5.00 0.54 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17930 BF_2 136.22 1.33 4585 -- -- -- -- -- 642916579 XM_008193556.1 49 1.20238e-13 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17931 BF_2 10.30 0.42 1312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17936 BF_2 17.00 1.52 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17938 BF_2 8.00 0.62 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1794 BF_2 9.00 0.66 857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17941 BF_2 644.67 8.81 3348 91091374 XP_973014.1 2065 7.7e-229 PREDICTED: FACT complex subunit Ssrp1 [Tribolium castaneum] 759066034 XM_011344158.1 265 7.38715e-134 PREDICTED: Cerapachys biroi FACT complex subunit Ssrp1 (LOC105282288), mRNA K09272 SSRP1 structure-specific recognition protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09272 Q293F6 1703 3.0e-188 FACT complex subunit Ssrp1 OS=Drosophila pseudoobscura pseudoobscura GN=Ssrp PE=3 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG0526 Nucleosome-binding factor SPN, POB3 subunit Cluster-8309.17942 BF_2 1.00 0.81 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17943 BF_2 60.00 4.88 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17949 BF_2 2.00 0.35 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17950 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17953 BF_2 26.75 0.60 2151 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02529 Cytochrome B6-F complex subunit 5 -- -- -- -- GO:0009512 cytochrome b6f complex -- -- Cluster-8309.17954 BF_2 59.27 3.78 943 642913029 XP_008201358.1 530 2.1e-51 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum]>gi|270001848|gb|EEZ98295.1| hypothetical protein TcasGA2_TC000745 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EAK8 344 3.3e-31 DNA damage-regulated autophagy modulator protein 1 OS=Xenopus tropicalis GN=dram1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-8309.17955 BF_2 11.00 1.07 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17958 BF_2 47.08 1.34 1752 478252789 ENN73182.1 1064 4.8e-113 hypothetical protein YQE_10236, partial [Dendroctonus ponderosae]>gi|546682445|gb|ERL92378.1| hypothetical protein D910_09692 [Dendroctonus ponderosae] -- -- -- -- -- K15108 SLC25A19, DNC, TPC1 solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15108 Q5IS35 624 2.1e-63 Mitochondrial thiamine pyrophosphate carrier OS=Macaca fascicularis GN=SLC25A19 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.17959 BF_2 40.64 1.24 1661 91092070 XP_970936.1 1008 1.4e-106 PREDICTED: mitochondrial thiamine pyrophosphate carrier [Tribolium castaneum]>gi|270004683|gb|EFA01131.1| hypothetical protein TcasGA2_TC010344 [Tribolium castaneum] -- -- -- -- -- K15108 SLC25A19, DNC, TPC1 solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15108 Q5IS35 602 6.9e-61 Mitochondrial thiamine pyrophosphate carrier OS=Macaca fascicularis GN=SLC25A19 PE=2 SV=1 PF00023 Ankyrin repeat GO:0006810 transport GO:0005515 protein binding GO:0016020 membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.17962 BF_2 7.00 1.43 492 91084873 XP_968370.1 525 4.2e-51 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270009235|gb|EFA05683.1| cytochrome P450 6BK11 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 361 1.8e-33 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0046872//GO:0016491//GO:0005506//GO:0016705 heme binding//metal ion binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.17963 BF_2 47.11 24.08 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17964 BF_2 17.77 0.47 1865 282847465 NP_001164281.1 213 2.4e-14 cytochrome P450 CYP6BK17 [Tribolium castaneum]>gi|161344971|gb|ABX64450.1| cytochrome P450 CYP6BK17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15681 Lymphocyte activation family X GO:0006955//GO:0051249 immune response//regulation of lymphocyte activation GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.17965 BF_2 4.00 5.97 298 741829513 AJA91072.1 332 6.1e-29 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 262 3.3e-22 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.17969 BF_2 141.15 5.33 1394 741829513 AJA91072.1 1294 8.1e-140 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 865 1.9e-91 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0051249//GO:0006955//GO:0055114 regulation of lymphocyte activation//immune response//oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.1797 BF_2 3.00 0.41 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17970 BF_2 128.09 3.34 1893 741829513 AJA91072.1 1587 1.2e-173 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 1062 3.6e-114 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.17974 BF_2 135.86 1.67 3684 642934488 XP_008197685.1 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934490|ref|XP_008197686.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|642934492|ref|XP_008197687.1| PREDICTED: uncharacterized protein LOC100142416 [Tribolium castaneum]>gi|270013516|gb|EFA09964.1| hypothetical protein TcasGA2_TC012121 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54316 599 3.4e-60 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 PF11023//PF00517 Zinc-ribbon containing domain//Retroviral envelope protein -- -- GO:0005198//GO:0003824 structural molecule activity//catalytic activity GO:0019031//GO:0005887 viral envelope//integral component of plasma membrane -- -- Cluster-8309.17976 BF_2 13.00 0.93 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17977 BF_2 257.80 4.00 2981 91078882 XP_972954.1 2710 1.1e-303 PREDICTED: ubiquitin carboxyl-terminal hydrolase 36 [Tribolium castaneum]>gi|270003709|gb|EFA00157.1| hypothetical protein TcasGA2_TC002978 [Tribolium castaneum] -- -- -- -- -- K11855 USP36_42 ubiquitin carboxyl-terminal hydrolase 36/42 http://www.genome.jp/dbget-bin/www_bget?ko:K11855 B3M3M6 1148 6.1e-124 Ubiquitin carboxyl-terminal hydrolase 36 OS=Drosophila ananassae GN=Usp36 PE=3 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006511//GO:0006508 protein deubiquitination//ubiquitin-dependent protein catabolic process//proteolysis GO:0004221//GO:0008234//GO:0036459 obsolete ubiquitin thiolesterase activity//cysteine-type peptidase activity//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.17978 BF_2 2.00 1.26 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17979 BF_2 2.00 1.71 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17980 BF_2 516.00 15.51 1679 584482886 AHJ09940.1 1465 1.4e-159 glycoside hydrolase family 28 [Apriona japonica] 584482885 KF724642.1 411 0 Apriona japonica glycoside hydrolase family 28 (gh28-2) mRNA, complete cds -- -- -- -- Q00446 739 9.1e-77 Endopolygalacturonase 1 OS=Colletotrichum lindemuthianum GN=PG1 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.17981 BF_2 100.00 14.23 581 -- -- -- -- -- 156764721 AK288106.1 578 0 Oryza sativa Japonica Group cDNA, clone: J075197I16, full insert sequence >gnl|BL_ORD_ID|6100043 Oryza sativa Japonica Group cDNA, clone: J075197I16, full insert sequence -- -- -- -- Q42465 268 1.3e-22 Prolamin PPROL 14P OS=Oryza sativa subsp. japonica GN=PROLM20 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.17982 BF_2 2.00 0.55 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.17984 BF_2 69.49 1.11 2909 850300312 XP_012861623.1 296 9.0e-24 PREDICTED: zinc finger protein 2 homolog [Echinops telfairi] -- -- -- -- -- -- -- -- -- P51523 276 7.7e-23 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF01363//PF13912//PF05191//PF13465//PF00096//PF05495 FYVE zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid//Zinc-finger double domain//Zinc finger, C2H2 type//CHY zinc finger GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0004017//GO:0046872 zinc ion binding//adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.17985 BF_2 110.26 1.62 3138 546679741 ERL90152.1 1446 4.3e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BKN5 456 1.1e-43 Gamma-tubulin complex component 5 OS=Mus musculus GN=Tubgcp5 PE=2 SV=2 PF04130//PF04505 Spc97 / Spc98 family//Interferon-induced transmembrane protein GO:0000226//GO:0090063//GO:0009607 microtubule cytoskeleton organization//positive regulation of microtubule nucleation//response to biotic stimulus -- -- GO:0016021//GO:0005815//GO:0000922 integral component of membrane//microtubule organizing center//spindle pole -- -- Cluster-8309.17987 BF_2 57.59 0.87 3064 270015294 EFA11742.1 1455 3.8e-158 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.17990 BF_2 18.75 0.68 1442 91094469 XP_967482.1 796 4.7e-82 PREDICTED: pre-mRNA-splicing factor 38B [Tribolium castaneum]>gi|270000754|gb|EEZ97201.1| hypothetical protein TcasGA2_TC004390 [Tribolium castaneum] -- -- -- -- -- K12850 PRPF38B pre-mRNA-splicing factor 38B http://www.genome.jp/dbget-bin/www_bget?ko:K12850 Q5VTL8 649 2.1e-66 Pre-mRNA-splicing factor 38B OS=Homo sapiens GN=PRPF38B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2888 Putative RNA binding protein Cluster-8309.17995 BF_2 576.00 12.14 2272 642918752 XP_008191569.1 523 3.3e-50 PREDICTED: protein slit-like [Tribolium castaneum]>gi|270005648|gb|EFA02096.1| hypothetical protein TcasGA2_TC007733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IIW9 133 2.3e-06 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Xenopus tropicalis GN=lingo1 PE=2 SV=1 PF09412//PF13855 Endoribonuclease XendoU//Leucine rich repeat -- -- GO:0016788//GO:0005515 hydrolase activity, acting on ester bonds//protein binding -- -- -- -- Cluster-8309.18006 BF_2 8.09 0.38 1188 270007525 EFA03973.1 630 6.8e-63 hypothetical protein TcasGA2_TC014120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VZD2 474 3.4e-46 Probable RNA methyltransferase CG11342 OS=Drosophila melanogaster GN=CG11342 PE=3 SV=1 PF06859 Bicoid-interacting protein 3 (Bin3) -- -- GO:0008168 methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.18008 BF_2 6.00 0.84 586 -- -- -- -- -- 462289926 APGK01054630.1 43 3.16023e-11 Dendroctonus ponderosae Seq01054640, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18010 BF_2 30.00 14.36 372 91080091 XP_968597.1 194 7.7e-13 PREDICTED: carboxypeptidase B [Tribolium castaneum]>gi|270004912|gb|EFA01360.1| carboxypeptidase A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02244 Carboxypeptidase activation peptide GO:0006508 proteolysis GO:0004180 carboxypeptidase activity -- -- -- -- Cluster-8309.18012 BF_2 64.42 1.25 2444 642934129 XP_008199288.1 888 1.7e-92 PREDICTED: putative zinc metalloproteinase YIL108W isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18015 BF_2 142.97 3.75 1880 741829513 AJA91072.1 1637 1.8e-179 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 1058 1.0e-113 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF15681//PF15836//PF00067 Lymphocyte activation family X//SSTK-interacting protein, TSSK6-activating co-chaperone protein//Cytochrome P450 GO:0055114//GO:0006955//GO:0051249 oxidation-reduction process//immune response//regulation of lymphocyte activation GO:0005506//GO:0020037//GO:0051087//GO:0016705 iron ion binding//heme binding//chaperone binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.18016 BF_2 147.47 3.41 2097 741829513 AJA91072.1 1281 3.9e-138 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 872 4.3e-92 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067//PF15836//PF15681 Cytochrome P450//SSTK-interacting protein, TSSK6-activating co-chaperone protein//Lymphocyte activation family X GO:0051249//GO:0006955//GO:0055114 regulation of lymphocyte activation//immune response//oxidation-reduction process GO:0051087//GO:0016705//GO:0020037//GO:0005506 chaperone binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.18017 BF_2 25.38 0.73 1744 642936411 XP_972396.2 569 1.2e-55 PREDICTED: zinc finger protein 714 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2VDP4 326 7.3e-29 Zinc finger protein 567 OS=Bos taurus GN=ZNF567 PE=2 SV=1 PF13465//PF00096//PF13912//PF04810//PF02892//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.18021 BF_2 81.00 0.70 5149 642916535 XP_008191598.1 1175 1.9e-125 PREDICTED: probable serine/threonine-protein kinase nek3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W2E1 395 2.2e-36 Protein stum OS=Drosophila melanogaster GN=stum PE=2 SV=3 PF14525//PF02325//PF00560 AraC-binding-like domain//YGGT family//Leucine Rich Repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.18022 BF_2 16.00 1.64 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18023 BF_2 15.82 0.73 1197 -- -- -- -- -- 157283802 EF653034.1 40 3.09414e-09 Platanus x acerifolia isolate F11T.24-st NBS-containing resistance-like protein pseudogene, complete sequence -- -- -- -- Q40392 394 6.6e-37 TMV resistance protein N OS=Nicotiana glutinosa GN=N PE=1 SV=1 PF00931//PF00004//PF01637//PF13676//PF01582 NB-ARC domain//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//TIR domain//TIR domain GO:0007165 signal transduction GO:0005524//GO:0043531//GO:0005515 ATP binding//ADP binding//protein binding -- -- -- -- Cluster-8309.18026 BF_2 28.00 2.23 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18032 BF_2 8.00 0.46 1017 659114130 AID61753.1 936 1.9e-98 fructose 1,6-biphosphate-aldolase A [Fenneropenaeus chinensis] 724970560 XM_010359278.1 252 3.6972e-127 PREDICTED: Rhinopithecus roxellana fructose-bisphosphate aldolase-like (LOC104659120), partial mRNA K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P07764 770 1.4e-80 Fructose-bisphosphate aldolase OS=Drosophila melanogaster GN=Ald PE=1 SV=5 PF00274 Fructose-bisphosphate aldolase class-I GO:0006098//GO:0006096//GO:0006020//GO:0015976//GO:0006094//GO:0006000//GO:0006013 pentose-phosphate shunt//glycolytic process//inositol metabolic process//carbon utilization//gluconeogenesis//fructose metabolic process//mannose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.18034 BF_2 18.10 0.46 1942 642936481 XP_008198455.1 1480 3.1e-161 PREDICTED: beta-1,3-glucosyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13675 B3GALTL UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13675 Q8BHT6 1156 4.7e-125 Beta-1,3-glucosyltransferase OS=Mus musculus GN=B3galtl PE=2 SV=3 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.18035 BF_2 65.00 10.79 539 -- -- -- -- -- 590587947 XM_007016027.1 77 3.63559e-30 Theobroma cacao GTP-binding protein Obg/CgtA, putative isoform 1 (TCM_041611) mRNA, complete cds -- -- -- -- P43390 208 1.1e-15 Metallothionein-like protein type 2 OS=Actinidia deliciosa GN=pKIWI504 PE=2 SV=1 PF02068//PF01439 Plant PEC family metallothionein//Metallothionein -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.18036 BF_2 25.06 0.39 3004 642934573 XP_008197722.1 1991 2.6e-220 PREDICTED: uncharacterized protein LOC658962 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10314 FBXO39 F-box protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K10314 -- -- -- -- PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18040 BF_2 146.97 6.79 1193 91078372 XP_974116.1 963 1.7e-101 PREDICTED: uncharacterized protein C9orf78 [Tribolium castaneum]>gi|270003886|gb|EFA00334.1| hypothetical protein TcasGA2_TC003173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZ63 544 2.6e-54 Uncharacterized protein C9orf78 OS=Homo sapiens GN=C9orf78 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3345 Uncharacterized conserved protein Cluster-8309.18042 BF_2 87.25 1.29 3126 642924396 XP_008194278.1 903 4.0e-94 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] -- -- -- -- -- K06637 BUB1B, BUBR1, MAD3L mitotic checkpoint serine/threonine-protein kinase BUB1 beta http://www.genome.jp/dbget-bin/www_bget?ko:K06637 Q9Z1S0 371 8.0e-34 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta OS=Mus musculus GN=Bub1b PE=1 SV=2 PF03852 DNA mismatch endonuclease Vsr GO:0006298 mismatch repair GO:0004519 endonuclease activity -- -- KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.18045 BF_2 11.99 0.50 1289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18046 BF_2 32.00 2.12 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18047 BF_2 136.66 1.09 5550 189236995 XP_970755.2 2750 4.7e-308 PREDICTED: uncharacterized protein LOC659345 [Tribolium castaneum]>gi|270006630|gb|EFA03078.1| hypothetical protein TcasGA2_TC010952 [Tribolium castaneum] -- -- -- -- -- K05724 FGD5_6 FYVE, RhoGEF and PH domain containing 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K05724 Q5DU31 206 1.9e-14 Interactor protein for cytohesin exchange factors 1 OS=Mus musculus GN=Ipcef1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18048 BF_2 245.52 1.65 6504 189236995 XP_970755.2 2880 0.0e+00 PREDICTED: uncharacterized protein LOC659345 [Tribolium castaneum]>gi|270006630|gb|EFA03078.1| hypothetical protein TcasGA2_TC010952 [Tribolium castaneum] -- -- -- -- -- K17536 CNKSR2, KSR2 connector enhancer of kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17536 Q8WXI2 492 1.5e-47 Connector enhancer of kinase suppressor of ras 2 OS=Homo sapiens GN=CNKSR2 PE=1 SV=1 PF00536//PF07647//PF00595//PF13180 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG1738 Membrane-associated guanylate kinase-interacting protein/connector enhancer of KSR-like Cluster-8309.18050 BF_2 247.00 3.64 3124 270004355 EFA00803.1 2392 8.7e-267 hypothetical protein TcasGA2_TC003689 [Tribolium castaneum] 573921410 XM_006648234.1 37 3.82442e-07 PREDICTED: Oryza brachyantha protein arginine N-methyltransferase 5-like (LOC102701698), mRNA K02516 PRMT5, HSL7 protein arginine N-methyltransferase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02516 Q5R698 1395 1.5e-152 Protein arginine N-methyltransferase 5 OS=Pongo abelii GN=PRMT5 PE=2 SV=3 PF05185 PRMT5 arginine-N-methyltransferase GO:0006479 protein methylation GO:0008168 methyltransferase activity -- -- KOG0822 Protein kinase inhibitor Cluster-8309.18056 BF_2 34.33 0.47 3352 478263032 ENN81432.1 444 7.1e-41 hypothetical protein YQE_02125, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V8F7 170 1.7e-10 Coiled-coil domain-containing protein 63 OS=Rattus norvegicus GN=Ccdc63 PE=2 SV=1 PF09728//PF01287//PF14942 Myosin-like coiled-coil protein//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//Organelle biogenesis, Muted-like protein GO:0006452//GO:0006448//GO:0045905//GO:0045901 translational frameshifting//regulation of translational elongation//positive regulation of translational termination//positive regulation of translational elongation GO:0003723//GO:0043022//GO:0019905//GO:0003746 RNA binding//ribosome binding//syntaxin binding//translation elongation factor activity GO:0005840//GO:0031083//GO:0030133 ribosome//BLOC-1 complex//transport vesicle -- -- Cluster-8309.18057 BF_2 74.58 0.90 3760 642933323 XP_008197368.1 1124 1.1e-119 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 627 2.0e-63 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.18062 BF_2 4.00 0.81 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18065 BF_2 20.00 4.12 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18066 BF_2 1.00 0.54 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18067 BF_2 12.00 0.39 1569 642914827 XP_008194958.1 265 1.9e-20 PREDICTED: lipase member H-B isoform X2 [Tribolium castaneum] -- -- -- -- -- K13618 PLA1A phospholipase A1 member A http://www.genome.jp/dbget-bin/www_bget?ko:K13618 P97535 171 6.2e-11 Phospholipase A1 member A OS=Rattus norvegicus GN=Pla1a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18069 BF_2 1.00 1.11 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1807 BF_2 3.23 0.41 618 642928681 XP_008199734.1 304 2.2e-25 PREDICTED: uncharacterized protein LOC662519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11380 Stealth protein CR2, conserved region 2 -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.18071 BF_2 533.00 36.44 899 270014250 EFA10698.1 519 3.8e-50 serine protease P128 [Tribolium castaneum] -- -- -- -- -- K09621 KLK12 kallikrein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09621 P00771 464 3.8e-45 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18075 BF_2 15.00 1.18 821 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18077 BF_2 32.28 2.34 863 642922882 XP_008200436.1 230 1.2e-16 PREDICTED: uncharacterized protein LOC103314920 [Tribolium castaneum]>gi|270006559|gb|EFA03007.1| hypothetical protein TcasGA2_TC010430 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16331//PF13949 TolA binding protein trimerisation//ALIX V-shaped domain binding to HIV GO:0070206 protein trimerization GO:0005515 protein binding -- -- -- -- Cluster-8309.18078 BF_2 9.90 0.52 1085 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18082 BF_2 113.29 4.95 1244 91081575 XP_975220.1 1328 8.3e-144 PREDICTED: maltase 2-like [Tribolium castaneum] 170055687 XM_001863658.1 42 2.48866e-10 Culex quinquefasciatus alpha-glucosidase, mRNA K14210 SLC3A1, RBAT solute carrier family 3 (neutral and basic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14210 O16098 1098 1.6e-118 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128 Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824 cation binding//catalytic activity -- -- -- -- Cluster-8309.18083 BF_2 18.00 1.16 937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18086 BF_2 70.00 1.05 3087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18087 BF_2 4.00 0.56 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18088 BF_2 117.53 1.65 3275 91083611 XP_969629.1 878 3.3e-91 PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|642924148|ref|XP_008194028.1| PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|270006834|gb|EFA03282.1| hypothetical protein TcasGA2_TC013217 [Tribolium castaneum] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 558 1.7e-55 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 PF13499//PF13405//PF13833//PF00036 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand GO:0006810 transport GO:0005509 calcium ion binding GO:0016020 membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.1809 BF_2 9.57 0.31 1575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18090 BF_2 42.00 3.25 828 91092366 XP_971881.1 287 2.8e-23 PREDICTED: DNA polymerase epsilon subunit 4 [Tribolium castaneum]>gi|270015716|gb|EFA12164.1| hypothetical protein TcasGA2_TC002314 [Tribolium castaneum] -- -- -- -- -- K03506 POLE4 DNA polymerase epsilon subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03506 Q9NR33 189 2.7e-13 DNA polymerase epsilon subunit 4 OS=Homo sapiens GN=POLE4 PE=1 SV=2 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1658 DNA polymerase epsilon, subunit C Cluster-8309.18095 BF_2 11.00 0.34 1651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18096 BF_2 2.99 1.19 391 752871781 XP_011253103.1 534 3.0e-52 PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus]>gi|752871783|ref|XP_011253104.1| PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus] 807017284 XM_012305000.1 92 1.18263e-38 PREDICTED: Ceratitis capitata RING finger protein 157 (LOC101463274), mRNA -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.18099 BF_2 546.02 1.76 13230 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 81 5.67061e-31 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 884 1.1e-92 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF00096//PF05495//PF13806//PF07776//PF13465//PF05121//PF01426//PF07975//PF09182//PF13912//PF00412//PF00641//PF08273//PF02845 Zinc finger, C2H2 type//CHY zinc finger//Rieske-like [2Fe-2S] domain//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Gas vesicle protein K//BAH domain//TFIIH C1-like domain//Bacterial purine repressor, N-terminal//C2H2-type zinc finger//LIM domain//Zn-finger in Ran binding protein and others//Zinc-binding domain of primase-helicase//CUE domain GO:0006807//GO:0042128//GO:0006351//GO:0055114//GO:0006269//GO:0006355//GO:0006281//GO:0031412 nitrogen compound metabolic process//nitrate assimilation//transcription, DNA-templated//oxidation-reduction process//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//DNA repair//gas vesicle organization GO:0046872//GO:0005515//GO:0003677//GO:0004386//GO:0003682//GO:0008942//GO:0008270//GO:0003896 metal ion binding//protein binding//DNA binding//helicase activity//chromatin binding//nitrite reductase [NAD(P)H] activity//zinc ion binding//DNA primase activity GO:0005657//GO:0000785//GO:0005634//GO:0005730 replication fork//chromatin//nucleus//nucleolus -- -- Cluster-8309.18100 BF_2 39.00 1.27 1573 241754591 XP_002406260.1 884 3.2e-92 secreted salivary gland peptide, putative [Ixodes scapularis]>gi|67083339|gb|AAY66605.1| putative salivary protein, partial [Ixodes scapularis]>gi|215506081|gb|EEC15575.1| secreted salivary gland peptide, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18101 BF_2 86.64 2.58 1692 642912979 XP_008201336.1 1347 7.0e-146 PREDICTED: leucine carboxyl methyltransferase 1 [Tribolium castaneum]>gi|270001907|gb|EEZ98354.1| hypothetical protein TcasGA2_TC000811 [Tribolium castaneum] -- -- -- -- -- K18203 LCMT1 http://www.genome.jp/dbget-bin/www_bget?ko:K18203 Q6P4Z6 721 1.1e-74 Leucine carboxyl methyltransferase 1 OS=Rattus norvegicus GN=Lcmt1 PE=2 SV=1 PF04072//PF03764 Leucine carboxyl methyltransferase//Elongation factor G, domain IV GO:0032259 methylation GO:0008168//GO:0005525 methyltransferase activity//GTP binding -- -- KOG2918 Carboxymethyl transferase Cluster-8309.18105 BF_2 21.00 0.59 1778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18109 BF_2 99.32 8.57 772 642920718 XP_008192534.1 265 9.4e-21 PREDICTED: LYR motif-containing protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXA0 209 1.2e-15 LYR motif-containing protein 5 OS=Taeniopygia guttata GN=LYRM5 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18112 BF_2 42.80 0.86 2366 282392019 NP_001164153.1 156 1.3e-07 fibroblast growth factor 8 precursor [Tribolium castaneum]>gi|270002739|gb|EEZ99186.1| fibroblast growth factor 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18114 BF_2 16.43 1.18 870 642934510 XP_008197694.1 285 5.1e-23 PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|642934512|ref|XP_008197695.1| PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|270013512|gb|EFA09960.1| hypothetical protein TcasGA2_TC012117 [Tribolium castaneum] 642934511 XM_008199473.1 115 4.52278e-51 PREDICTED: Tribolium castaneum AP-1 complex subunit gamma-1 (LOC100142537), transcript variant X3, mRNA K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 165 1.7e-10 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02883 Adaptin C-terminal domain GO:0015031//GO:0016192//GO:0006886 protein transport//vesicle-mediated transport//intracellular protein transport GO:0008565 protein transporter activity GO:0044431//GO:0030131 Golgi apparatus part//clathrin adaptor complex -- -- Cluster-8309.1812 BF_2 2.00 0.31 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18122 BF_2 2.00 3.26 294 270017072 EFA13518.1 183 1.2e-11 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18124 BF_2 7.00 0.56 813 759069777 XP_011344442.1 228 1.9e-16 PREDICTED: uncharacterized protein LOC105283414 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18125 BF_2 1.00 1.46 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18126 BF_2 153.11 3.17 2310 478250251 ENN70751.1 828 1.5e-85 hypothetical protein YQE_12540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AZB8 223 8.5e-17 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF01609//PF04827//PF09057 Transposase DDE domain//Plant transposon protein//Second Mitochondria-derived Activator of Caspases GO:0006919//GO:0006915//GO:0006313 activation of cysteine-type endopeptidase activity involved in apoptotic process//apoptotic process//transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity GO:0005739 mitochondrion -- -- Cluster-8309.18127 BF_2 21.28 0.75 1473 795014016 XP_011883734.1 545 6.1e-53 PREDICTED: putative nuclease HARBI1 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- -- -- Cluster-8309.18133 BF_2 95.11 1.05 4066 478261830 ENN80953.1 694 8.9e-70 hypothetical protein YQE_02658, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4KM51 143 2.8e-07 Transcription elongation factor, mitochondrial OS=Rattus norvegicus GN=Tefm PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18135 BF_2 259.00 17.82 895 642938132 XP_008199779.1 554 3.3e-54 PREDICTED: glycine cleavage system H protein, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K02437 gcvH, GCSH glycine cleavage system H protein http://www.genome.jp/dbget-bin/www_bget?ko:K02437 Q9U616 471 5.8e-46 Glycine cleavage system H protein, mitochondrial OS=Drosophila melanogaster GN=ppl PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3373 Glycine cleavage system H protein (lipoate-binding) Cluster-8309.18136 BF_2 9.44 0.85 752 642934473 XP_008197678.1 690 4.8e-70 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q9EQG6 225 1.6e-17 Kinase D-interacting substrate of 220 kDa OS=Rattus norvegicus GN=Kidins220 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18138 BF_2 388.30 5.62 3178 642915323 XP_008190571.1 2812 0.0e+00 PREDICTED: valine--tRNA ligase [Tribolium castaneum]>gi|270003973|gb|EFA00421.1| hypothetical protein TcasGA2_TC003272 [Tribolium castaneum] 470518689 XM_004353314.1 56 1.06672e-17 Acanthamoeba castellanii str. Neff valine-tRNA ligase (ACA1_300880) mRNA, complete cds K01873 VARS, valS valyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01873 Q5ST30 1875 3.2e-208 Valine--tRNA ligase, mitochondrial OS=Homo sapiens GN=VARS2 PE=1 SV=2 PF04905//PF09334//PF00133//PF08264//PF13603 NAB conserved region 2 (NCD2)//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA//Leucyl-tRNA synthetase, Domain 2 GO:0006418//GO:0045892//GO:0006412 tRNA aminoacylation for protein translation//negative regulation of transcription, DNA-templated//translation GO:0000166//GO:0004812//GO:0002161//GO:0005524//GO:0016874 nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity//ATP binding//ligase activity GO:0005634 nucleus KOG0432 Valyl-tRNA synthetase Cluster-8309.18140 BF_2 62.00 2.04 1559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18141 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18142 BF_2 496.47 7.29 3135 91080171 XP_970238.1 4040 0.0e+00 PREDICTED: transportin-3 [Tribolium castaneum] 658920433 XM_008401725.1 75 2.8842e-28 PREDICTED: Poecilia reticulata transportin 3 (tnpo3), mRNA K15436 TRPO3, MTR10 transportin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K15436 Q6P2B1 2264 2.5e-253 Transportin-3 OS=Mus musculus GN=Tnpo3 PE=1 SV=1 PF03810//PF00452//PF05823 Importin-beta N-terminal domain//Apoptosis regulator proteins, Bcl-2 family//Nematode fatty acid retinoid binding protein (Gp-FAR-1) GO:0042981//GO:0006886 regulation of apoptotic process//intracellular protein transport GO:0008536//GO:0008289 Ran GTPase binding//lipid binding -- -- KOG2081 Nuclear transport regulator Cluster-8309.18144 BF_2 122.54 12.39 701 642925206 XP_008194468.1 638 4.8e-64 PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum]>gi|642925208|ref|XP_008194469.1| PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum] -- -- -- -- -- K15153 MED31, SOH1 mediator of RNA polymerase II transcription subunit 31 http://www.genome.jp/dbget-bin/www_bget?ko:K15153 Q8IH24 483 1.8e-47 Mediator of RNA polymerase II transcription subunit 31 OS=Drosophila melanogaster GN=MED31 PE=1 SV=2 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4086 Transcriptional regulator SOH1 Cluster-8309.18148 BF_2 1.00 0.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18152 BF_2 2.00 0.68 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18154 BF_2 253.00 12.18 1156 270006030 EFA02478.1 561 6.7e-55 hypothetical protein TcasGA2_TC008169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K5B3 205 5.2e-15 Multiple coagulation factor deficiency protein 2 homolog OS=Rattus norvegicus GN=Mcfd2 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG4065 Uncharacterized conserved protein Cluster-8309.18158 BF_2 130.50 3.31 1937 478261514 ENN80859.1 705 2.2e-71 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 P13582 474 5.6e-46 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18159 BF_2 16.00 1.15 870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18165 BF_2 352.15 15.71 1225 91082925 XP_972790.1 599 2.8e-59 PREDICTED: mitochondrial import inner membrane translocase subunit Tim21 [Tribolium castaneum]>gi|270007057|gb|EFA03505.1| hypothetical protein TcasGA2_TC013506 [Tribolium castaneum] -- -- -- -- -- K17796 TIM21 mitochondrial import inner membrane translocase subunit TIM21 http://www.genome.jp/dbget-bin/www_bget?ko:K17796 Q3SZV6 346 2.5e-31 Mitochondrial import inner membrane translocase subunit Tim21 OS=Bos taurus GN=TIMM21 PE=2 SV=1 PF08294 TIM21 GO:0030150 protein import into mitochondrial matrix -- -- GO:0005744 mitochondrial inner membrane presequence translocase complex KOG4836 Uncharacterized conserved protein Cluster-8309.18168 BF_2 89.00 2.19 1988 546682221 ERL92182.1 951 6.9e-100 hypothetical protein D910_09502 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZJA9 316 1.2e-27 Loss of heterozygosity 12 chromosomal region 1 protein homolog OS=Gallus gallus GN=LOH12CR1 PE=2 SV=1 PF04420//PF02601//PF16276 CHD5-like protein//Exonuclease VII, large subunit//Nucleophosmin C-terminal domain GO:0071816//GO:0006308 tail-anchored membrane protein insertion into ER membrane//DNA catabolic process GO:0003676//GO:0008855 nucleic acid binding//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.18172 BF_2 16.98 0.60 1474 -- -- -- -- -- 357494166 XM_003617324.1 41 1.06536e-09 Medicago truncatula NBS-containing resistance-like protein (MTR_5g090870) mRNA, complete cds -- -- -- -- Q40392 432 3.2e-41 TMV resistance protein N OS=Nicotiana glutinosa GN=N PE=1 SV=1 PF01637//PF13676//PF01582//PF00931//PF00004 Archaeal ATPase//TIR domain//TIR domain//NB-ARC domain//ATPase family associated with various cellular activities (AAA) GO:0007165 signal transduction GO:0043531//GO:0005515//GO:0005524 ADP binding//protein binding//ATP binding -- -- -- -- Cluster-8309.18173 BF_2 25.00 0.95 1384 343414369 CCD21014.1 158 4.3e-08 leucine-rich repeat protein, putative [Trypanosoma vivax Y486] -- -- -- -- -- -- -- -- -- Q9SZ67 608 1.2e-61 Probable WRKY transcription factor 19 OS=Arabidopsis thaliana GN=WRKY19 PE=2 SV=1 PF15754//PF00560//PF13855 Sperm equatorial segment protein 1//Leucine Rich Repeat//Leucine rich repeat GO:0007340//GO:0007342 acrosome reaction//fusion of sperm to egg plasma membrane GO:0005515 protein binding GO:0001669 acrosomal vesicle -- -- Cluster-8309.18176 BF_2 29.03 0.86 1706 642922712 XP_008193292.1 145 1.7e-06 PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922714|ref|XP_008193293.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922716|ref|XP_008193294.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922718|ref|XP_008193295.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18179 BF_2 4.83 1.11 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00609 Diacylglycerol kinase accessory domain GO:0046486//GO:0009395//GO:0007205 glycerolipid metabolic process//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway GO:0004143 diacylglycerol kinase activity -- -- -- -- Cluster-8309.18180 BF_2 18.17 1.11 973 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11956 Ankyrin-G binding motif of KCNQ2-3 GO:0006813 potassium ion transport GO:0005267 potassium channel activity GO:0016020 membrane -- -- Cluster-8309.18182 BF_2 13.00 3.46 444 195044350 XP_001991805.1 200 1.8e-13 GH12862 [Drosophila grimshawi]>gi|193901563|gb|EDW00430.1| GH12862 [Drosophila grimshawi] -- -- -- -- -- -- -- -- -- D2WKD9 158 5.6e-10 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.18184 BF_2 8.00 1.18 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18185 BF_2 28.04 0.34 3695 642936336 XP_008198400.1 1993 1.9e-220 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1246 3.3e-135 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF00570//PF00196//PF09382//PF00270//PF06480//PF04851 HRDC domain//Bacterial regulatory proteins, luxR family//RQC domain//DEAD/DEAH box helicase//FtsH Extracellular//Type III restriction enzyme, res subunit GO:0006355//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA replication//DNA repair GO:0008270//GO:0003676//GO:0043140//GO:0004222//GO:0005524//GO:0016787//GO:0003677 zinc ion binding//nucleic acid binding//ATP-dependent 3'-5' DNA helicase activity//metalloendopeptidase activity//ATP binding//hydrolase activity//DNA binding GO:0005622//GO:0005657//GO:0016021 intracellular//replication fork//integral component of membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.18186 BF_2 137.65 1.72 3642 642936336 XP_008198400.1 2020 1.4e-223 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1274 1.8e-138 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF06480//PF04851//PF00270//PF00196//PF00570//PF09382 FtsH Extracellular//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Bacterial regulatory proteins, luxR family//HRDC domain//RQC domain GO:0006355//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA replication//DNA repair GO:0043140//GO:0008270//GO:0003676//GO:0005524//GO:0004222//GO:0003677//GO:0016787 ATP-dependent 3'-5' DNA helicase activity//zinc ion binding//nucleic acid binding//ATP binding//metalloendopeptidase activity//DNA binding//hydrolase activity GO:0005622//GO:0016021//GO:0005657 intracellular//integral component of membrane//replication fork KOG0351 ATP-dependent DNA helicase Cluster-8309.18188 BF_2 66.91 0.82 3698 642936336 XP_008198400.1 1992 2.5e-220 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1259 1.0e-136 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF00270//PF00570//PF00196//PF09382//PF06480//PF04851 DEAD/DEAH box helicase//HRDC domain//Bacterial regulatory proteins, luxR family//RQC domain//FtsH Extracellular//Type III restriction enzyme, res subunit GO:0006281//GO:0006355//GO:0006260 DNA repair//regulation of transcription, DNA-templated//DNA replication GO:0005524//GO:0004222//GO:0003677//GO:0016787//GO:0008270//GO:0003676//GO:0043140 ATP binding//metalloendopeptidase activity//DNA binding//hydrolase activity//zinc ion binding//nucleic acid binding//ATP-dependent 3'-5' DNA helicase activity GO:0016021//GO:0005657//GO:0005622 integral component of membrane//replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.1819 BF_2 3.00 0.90 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18192 BF_2 24.00 4.29 521 506965393 AGM32087.1 564 1.3e-55 40S ribosomal protein S10 [Coptotermes formosanus] -- -- -- -- -- K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 P63326 545 8.8e-55 40S ribosomal protein S10 OS=Rattus norvegicus GN=Rps10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3344 40s ribosomal protein s10 Cluster-8309.18193 BF_2 64.53 2.25 1489 795088502 XP_011878920.1 1765 2.1e-194 PREDICTED: tubulin beta-1 chain [Vollenhovia emeryi] 689542279 LL999081.1 170 2.09554e-81 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_scaffold0000014 K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 1755 1.2e-194 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.18195 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.182 BF_2 2.00 0.32 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18201 BF_2 170.56 2.13 3639 549438545 AGX25161.1 2415 2.2e-269 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 1472 2.0e-161 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF02129//PF00930//PF03583//PF01738//PF00326 X-Pro dipeptidyl-peptidase (S15 family)//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Secretory lipase//Dienelactone hydrolase family//Prolyl oligopeptidase family GO:0046486//GO:0006508//GO:0016042 glycerolipid metabolic process//proteolysis//lipid catabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.18203 BF_2 39.91 1.21 1665 642919261 XP_008191798.1 1255 3.2e-135 PREDICTED: glucosamine-6-phosphate isomerase isoform X2 [Tribolium castaneum] 195473851 XM_002089170.1 181 1.80324e-87 Drosophila yakuba GE25482 (Dyak\GE25482), partial mRNA K02564 nagB, GNPDA glucosamine-6-phosphate deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K02564 Q16HW7 1169 1.2e-126 Glucosamine-6-phosphate isomerase OS=Aedes aegypti GN=Gnpda1 PE=3 SV=1 PF01182//PF11975 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase//Family 4 glycosyl hydrolase C-terminal domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG3148 Glucosamine-6-phosphate isomerase Cluster-8309.18205 BF_2 28.00 0.65 2078 751239627 XP_011173810.1 200 8.7e-13 PREDICTED: uncharacterized protein LOC105205974, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.18207 BF_2 20.60 0.47 2112 642933386 XP_008197395.1 1021 5.6e-108 PREDICTED: HEAT repeat-containing protein 2 [Tribolium castaneum]>gi|270011379|gb|EFA07827.1| hypothetical protein TcasGA2_TC005396 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q86Y56 377 1.1e-34 Dynein assembly factor 5, axonemal OS=Homo sapiens GN=DNAAF5 PE=1 SV=4 PF00440//PF11640//PF02985 Bacterial regulatory proteins, tetR family//Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0003677//GO:0004674//GO:0005515 DNA binding//protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.18211 BF_2 164.40 1.22 5903 795018288 XP_011859156.1 2928 0.0e+00 PREDICTED: uncharacterized protein K02A2.6-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P0CT41 925 8.7e-98 Transposon Tf2-12 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-12 PE=3 SV=1 PF17068//PF05087//PF13683//PF02035//PF00665//PF00098 Required for respiratory growth protein 8 mitochondrial//Rotavirus VP2 protein//Integrase core domain//Coagulin//Integrase core domain//Zinc knuckle GO:0042381//GO:0015074//GO:0000002 hemolymph coagulation//DNA integration//mitochondrial genome maintenance GO:0003723//GO:0008270//GO:0003676 RNA binding//zinc ion binding//nucleic acid binding GO:0005576//GO:0019013 extracellular region//viral nucleocapsid -- -- Cluster-8309.18212 BF_2 77.34 3.32 1262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18214 BF_2 43.53 0.67 2999 91083749 XP_971342.1 2169 6.0e-241 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 1088 5.5e-117 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18216 BF_2 90.91 2.06 2130 91079170 XP_967650.1 875 4.8e-91 PREDICTED: viral IAP-associated factor homolog [Tribolium castaneum]>gi|270004241|gb|EFA00689.1| hypothetical protein TcasGA2_TC003566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MR62 659 2.2e-67 Viral IAP-associated factor homolog OS=Drosophila melanogaster GN=viaf PE=1 SV=1 PF00445//PF01528//PF04104 Ribonuclease T2 family//Herpesvirus glycoprotein M//Eukaryotic and archaeal DNA primase, large subunit GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896//GO:0003723//GO:0033897 DNA primase activity//RNA binding//ribonuclease T2 activity GO:0005657//GO:0016020//GO:0005730 replication fork//membrane//nucleolus KOG3170 Conserved phosducin-like protein Cluster-8309.18218 BF_2 1.00 1.96 286 307203294 EFN82447.1 155 1.9e-08 Putative uncharacterized protein FLJ37770, partial [Harpegnathos saltator]>gi|307206466|gb|EFN84499.1| Putative uncharacterized protein FLJ37770, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18219 BF_2 143.00 2.26 2938 91076598 XP_968579.1 2458 1.8e-274 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] -- -- -- -- -- K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 1891 4.2e-210 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF02177//PF01496//PF00672 Amyloid A4 N-terminal heparin-binding//V-type ATPase 116kDa subunit family//HAMP domain GO:0015992//GO:0015991//GO:0007165 proton transport//ATP hydrolysis coupled proton transport//signal transduction GO:0008201//GO:0004871//GO:0015078 heparin binding//signal transducer activity//hydrogen ion transmembrane transporter activity GO:0033179//GO:0016021 proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.1822 BF_2 1.00 0.38 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.18225 BF_2 26.51 0.47 2648 546684608 ERL94225.1 1617 5.4e-177 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q7ZX21 712 1.9e-73 OTU domain-containing protein 5-A OS=Xenopus laevis GN=otud5-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.18230 BF_2 3.00 0.50 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18232 BF_2 97.00 2.73 1771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.18233 BF_2 35.00 2.28 929 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18235 BF_2 8.00 0.59 853 646707759 KDR14377.1 288 2.2e-23 Down syndrome cell adhesion molecule-like protein, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9VS29 172 2.6e-11 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF07689//PF04498//PF13895 KaiB domain//Poxvirus nucleic acid binding protein VP8/L4R//Immunoglobulin domain GO:0048511 rhythmic process GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0019028 viral capsid -- -- Cluster-8309.18236 BF_2 127.00 3.26 1916 13273161 AAK17768.1 2073 5.2e-230 cytochrome c oxidase subunit I [Homo sapiens]>gi|32892928|gb|AAP89610.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892942|gb|AAP89623.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892956|gb|AAP89636.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892970|gb|AAP89649.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|32892984|gb|AAP89662.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|69065316|gb|AAZ03038.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072717|emb|CAJ98078.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|111072731|emb|CAJ98091.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072745|emb|CAJ98104.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072759|emb|CAJ98117.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072773|emb|CAJ98130.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072787|emb|CAJ98143.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|111072801|emb|CAJ98156.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|170664840|gb|ACB28990.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|171453140|dbj|BAG15084.1| cytochrome oxydase subunit I [Homo sapiens]>gi|171453602|dbj|BAG15513.1| cytochrome oxydase subunit I [Homo sapiens]>gi|189179033|dbj|BAG38865.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|292596803|gb|ADE33275.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|292596873|gb|ADE33340.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|305657132|gb|ADM60881.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|359471014|gb|AEV50453.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|363902165|gb|AEW43561.1| cytochrome c oxidase subunit I [Homo sapiens]>gi|375071522|gb|AFA33462.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381221049|gb|AFF63986.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381228987|gb|AFF71357.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381232263|gb|AFF74399.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381233957|gb|AFF75972.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381234083|gb|AFF76089.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381235427|gb|AFF77337.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381244597|gb|AFF85852.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381246641|gb|AFF87750.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381248923|gb|AFF89869.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381249455|gb|AFF90363.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381250477|gb|AFF91312.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381254705|gb|AFF95238.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381256917|gb|AFF97292.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381258261|gb|AFF98540.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381259549|gb|AFF99736.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381264406|gb|AFG04247.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381264616|gb|AFG04442.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381274192|gb|AFG13334.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|381276250|gb|AFG15245.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|396579972|gb|AFN86827.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|396579986|gb|AFN86840.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|396580000|gb|AFN86853.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397179351|gb|AFO24189.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397181157|gb|AFO25866.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397181731|gb|AFO26399.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397182697|gb|AFO27296.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397187051|gb|AFO31339.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397187121|gb|AFO31404.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397188465|gb|AFO32652.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397188857|gb|AFO33016.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397192399|gb|AFO36305.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|397193155|gb|AFO37007.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|401783337|gb|AFQ05215.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|410062024|gb|AFV54302.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|443540395|gb|AEH03913.2| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|481044970|gb|AGJ95267.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|525316009|gb|AGR43553.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|525316513|gb|AGR44021.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|525316527|gb|AGR44034.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|530848180|gb|AGT54285.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|530848278|gb|AGT54376.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545749835|gb|AGW54088.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545750283|gb|AGW54504.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545758710|gb|AGW62329.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545767516|gb|AGW70506.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545767670|gb|AGW70649.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545768048|gb|AGW71000.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774082|gb|AGW76603.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774110|gb|AGW76629.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774124|gb|AGW76642.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545774404|gb|AGW76902.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545775706|gb|AGW78111.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545776406|gb|AGW78761.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545776882|gb|AGW79203.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|545778016|gb|AGW80256.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|552099765|gb|AGY46043.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|556712696|gb|AGZ76177.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|570436927|gb|AHE78967.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|606232060|gb|AHW38074.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|614528043|gb|AHX53206.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|656331059|gb|AID08560.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|700279764|gb|AIU60764.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|700281038|gb|AIU61947.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|753364022|gb|AJI44293.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]>gi|768802593|gb|AJV87742.1| cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens] 893712435 KT277303.1 1916 0 Homo sapiens haplogroup I4a mitochondrion, complete genome K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00395 2061 5.3e-230 Cytochrome c oxidase subunit 1 OS=Homo sapiens GN=MT-CO1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.18237 BF_2 75.16 2.08 1797 385199936 AFI45016.1 1376 3.2e-149 cytochrome P450 CYP4BD4v1 [Dendroctonus ponderosae] 826411405 XM_012687282.1 45 7.79569e-12 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105840370), partial mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VL92 956 6.7e-102 Cytochrome P450 4e3 OS=Drosophila melanogaster GN=Cyp4e3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.18239 BF_2 19.14 0.51 1846 766928720 XP_011496419.1 298 3.3e-24 PREDICTED: dihydrofolate reductase [Ceratosolen solmsi marchali] 389612312 AK403254.1 35 2.90226e-06 Papilio xuthus mRNA for dihydrofolate reductase, partial cds, sequence id: Px-1353, expressed in epidermis K00287 folA dihydrofolate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00287 P04753 229 1.4e-17 Dihydrofolate reductase OS=Mesocricetus auratus GN=DHFR PE=2 SV=4 PF00186 Dihydrofolate reductase GO:0006761//GO:0006545//GO:0055114//GO:0009165//GO:0046656 dihydrofolate biosynthetic process//glycine biosynthetic process//oxidation-reduction process//nucleotide biosynthetic process//folic acid biosynthetic process GO:0004146 dihydrofolate reductase activity -- -- KOG1324 Dihydrofolate reductase Cluster-8309.1824 BF_2 11.00 0.33 1692 817079246 XP_012262028.1 496 3.4e-47 PREDICTED: uncharacterized protein LOC105689528 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18240 BF_2 8.00 0.71 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18241 BF_2 41.00 0.57 3304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18242 BF_2 6.00 0.66 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18243 BF_2 294.71 7.76 1875 189240381 XP_001815436.1 708 9.7e-72 PREDICTED: uncharacterized protein LOC100142429 [Tribolium castaneum]>gi|270011479|gb|EFA07927.1| hypothetical protein TcasGA2_TC005505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05041 Pecanex protein (C-terminus) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.18249 BF_2 119.41 1.43 3772 270004569 EFA01017.1 1392 9.5e-151 hypothetical protein TcasGA2_TC003931 [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 7.4e-34 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.1825 BF_2 5.00 1.42 434 664777237 XP_008507911.1 603 3.4e-60 PREDICTED: 60S ribosomal protein L30-like [Equus przewalskii] 324021697 NM_000989.3 434 0 Homo sapiens ribosomal protein L30 (RPL30), mRNA K02908 RP-L30e, RPL30 large subunit ribosomal protein L30e http://www.genome.jp/dbget-bin/www_bget?ko:K02908 P62890 587 9.9e-60 60S ribosomal protein L30 OS=Rattus norvegicus GN=Rpl30 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2988 60S ribosomal protein L30 Cluster-8309.18252 BF_2 36.00 3.32 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18255 BF_2 14.71 1.81 628 478259443 ENN79333.1 141 1.8e-06 hypothetical protein YQE_04242, partial [Dendroctonus ponderosae]>gi|546675184|gb|ERL86420.1| hypothetical protein D910_03827 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18263 BF_2 22.76 0.68 1692 189239355 XP_974286.2 2019 8.4e-224 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 1597 3.0e-176 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF00622//PF00270//PF04851 SPRY domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003676//GO:0016787//GO:0003677//GO:0008026//GO:0005515 ATP binding//nucleic acid binding//hydrolase activity//DNA binding//ATP-dependent helicase activity//protein binding -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.18265 BF_2 19.77 0.72 1440 189239355 XP_974286.2 1156 8.4e-124 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 955 7.0e-102 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 -- -- -- -- GO:0008026//GO:0005524//GO:0003676 ATP-dependent helicase activity//ATP binding//nucleic acid binding -- -- KOG0349 Putative DEAD-box RNA helicase DDX1 Cluster-8309.18267 BF_2 16.80 0.38 2114 332374200 AEE62241.1 1086 1.6e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17569 GPATCH2 G patch domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17569 -- -- -- -- PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.18268 BF_2 321.20 7.58 2060 332374200 AEE62241.1 1094 1.9e-116 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17569 GPATCH2 G patch domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17569 -- -- -- -- PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.18272 BF_2 47.00 1.37 1724 556717865 XP_005954837.1 531 3.0e-51 PREDICTED: glucose-1-phosphate adenylyltransferase large subunit, chloroplastic/amyloplastic-like [Pantholops hodgsonii] 115476013 NM_001068138.1 1692 0 Oryza sativa Japonica Group Os08g0345800 (Os08g0345800) mRNA, complete cds -- -- -- -- P15280 2154 7.8e-241 Glucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic OS=Oryza sativa subsp. japonica GN=AGPS PE=2 SV=4 PF00483//PF07959//PF15202 Nucleotidyl transferase//L-fucokinase//Adipogenin GO:0009058//GO:0045444 biosynthetic process//fat cell differentiation GO:0016779//GO:0016772 nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.18273 BF_2 71.00 2.28 1589 642935206 XP_008199690.1 1226 7.1e-132 PREDICTED: deoxynucleotidyltransferase terminal-interacting protein 1 [Tribolium castaneum]>gi|270014206|gb|EFA10654.1| hypothetical protein TcasGA2_TC016291 [Tribolium castaneum] -- -- -- -- -- K08707 DNTTIP1 deoxynucleotidyltransferase terminal-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08707 Q9H147 458 3.3e-44 Deoxynucleotidyltransferase terminal-interacting protein 1 OS=Homo sapiens GN=DNTTIP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4801 Member of the steroid/thyroid receptor superfamily Cluster-8309.18279 BF_2 49.44 0.63 3547 229892261 NP_001153542.1 2160 7.9e-240 nicotinic acetylcholine receptor alpha6 subunit isoform 8 precursor [Tribolium castaneum]>gi|227439225|gb|ACP31290.1| nicotinic acetylcholine receptor a6 subunit isoform XIV [Tribolium castaneum] 642910720 XR_511456.1 545 0 PREDICTED: Tribolium castaneum nicotinic acetylcholine receptor alpha 6 subunit (nAChRa6), transcript variant X5, misc_RNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P22770 1046 4.9e-112 Neuronal acetylcholine receptor subunit alpha-7 OS=Gallus gallus GN=CHRNA7 PE=1 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006812//GO:0006810//GO:0007165 ion transport//cation transport//transport//signal transduction GO:0005230//GO:0004889 extracellular ligand-gated ion channel activity//acetylcholine-activated cation-selective channel activity GO:0045211//GO:0030054//GO:0016020//GO:0016021//GO:0005886 postsynaptic membrane//cell junction//membrane//integral component of membrane//plasma membrane KOG3646 Acetylcholine receptor Cluster-8309.18280 BF_2 102.00 9.00 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02028 BCCT, betaine/carnitine/choline family transporter GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.18281 BF_2 14.34 0.78 1057 91092480 XP_967611.1 1090 2.8e-116 PREDICTED: probable dynactin subunit 2 [Tribolium castaneum]>gi|270012933|gb|EFA09381.1| hypothetical protein TcasGA2_TC001942 [Tribolium castaneum] -- -- -- -- -- K10424 DCTN2 dynactin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10424 Q1HQF2 591 8.3e-60 Probable dynactin subunit 2 OS=Aedes aegypti GN=Dmn PE=2 SV=2 PF03449//PF16519//PF04513//PF15724//PF02244//PF02346 Transcription elongation factor, N-terminal//Tetramerisation domain of TRPM//Baculovirus polyhedron envelope protein, PEP, C terminus//TMEM119 family//Carboxypeptidase activation peptide//Chordopoxvirus multifunctional envelope protein A27 GO:0019064//GO:0032784//GO:0001503//GO:0051262//GO:0006508//GO:0007017 fusion of virus membrane with host plasma membrane//regulation of DNA-templated transcription, elongation//ossification//protein tetramerization//proteolysis//microtubule-based process GO:0005198//GO:0004180//GO:0003677 structural molecule activity//carboxypeptidase activity//DNA binding GO:0019031//GO:0019028//GO:0005869 viral envelope//viral capsid//dynactin complex -- -- Cluster-8309.18287 BF_2 2.73 0.57 489 478259929 ENN79731.1 340 1.2e-29 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 191 9.3e-14 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.18290 BF_2 37.02 0.74 2386 72094941 XP_798033.1 651 5.0e-65 PREDICTED: protein SpAN [Strongylocentrotus purpuratus] -- -- -- -- -- K08606 MEP1B meprin B http://www.genome.jp/dbget-bin/www_bget?ko:K08606 P42674 597 3.8e-60 Blastula protease 10 OS=Paracentrotus lividus GN=BP10 PE=2 SV=1 PF00413//PF01400 Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.18292 BF_2 42.98 0.85 2406 72094941 XP_798033.1 801 2.1e-82 PREDICTED: protein SpAN [Strongylocentrotus purpuratus] -- -- -- -- -- K08076 E3.4.24.21 astacin http://www.genome.jp/dbget-bin/www_bget?ko:K08076 P42674 722 1.2e-74 Blastula protease 10 OS=Paracentrotus lividus GN=BP10 PE=2 SV=1 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.18297 BF_2 47.57 0.49 4381 821385245 XP_012386849.1 708 2.3e-71 PREDICTED: zinc finger protein 850-like [Orcinus orca] 795495644 XM_011710948.1 39 4.15991e-08 PREDICTED: Macaca nemestrina zinc finger protein 713 (ZNF713), transcript variant X5, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ECI4 679 2.2e-69 Zinc finger protein 470 OS=Homo sapiens GN=ZNF470 PE=2 SV=3 PF07776//PF13912//PF02892//PF02178//PF13465//PF00096//PF08054 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//BED zinc finger//AT hook motif//Zinc-finger double domain//Zinc finger, C2H2 type//Leucine operon leader peptide GO:0009098 leucine biosynthetic process GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.18300 BF_2 14.42 0.33 2099 646717950 KDR20605.1 2060 1.8e-228 Elongator complex protein 3 [Zootermopsis nevadensis] 766940529 XM_011504565.1 405 0 PREDICTED: Ceratosolen solmsi marchali probable elongator complex protein 3 (LOC105366209), transcript variant X1, mRNA K07739 ELP3, KAT9 elongator complex protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07739 Q9VQZ6 2010 4.7e-224 Probable elongator complex protein 3 OS=Drosophila melanogaster GN=Elp3 PE=2 SV=1 PF04055 Radical SAM superfamily -- -- GO:0051536//GO:0003824 iron-sulfur cluster binding//catalytic activity -- -- KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase Cluster-8309.18308 BF_2 183.63 3.96 2226 642920057 XP_008192187.1 1719 6.8e-189 PREDICTED: mitochondrial import inner membrane translocase subunit TIM44 [Tribolium castaneum] -- -- -- -- -- K17804 TIM44 mitochondrial import inner membrane translocase subunit TIM44 http://www.genome.jp/dbget-bin/www_bget?ko:K17804 O43615 1032 1.3e-110 Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens GN=TIMM44 PE=1 SV=2 PF08336//PF07464//PF05478//PF07926//PF02932 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Apolipophorin-III precursor (apoLp-III)//Prominin//TPR/MLP1/MLP2-like protein//Neurotransmitter-gated ion-channel transmembrane region GO:0006606//GO:0055114//GO:0006811//GO:0006525//GO:0018401//GO:0006869//GO:0006560 protein import into nucleus//oxidation-reduction process//ion transport//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//lipid transport//proline metabolic process GO:0008289//GO:0004656//GO:0016702 lipid binding//procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005576//GO:0016020//GO:0016021//GO:0005783 extracellular region//membrane//integral component of membrane//endoplasmic reticulum KOG2580 Mitochondrial import inner membrane translocase, subunit TIM44 Cluster-8309.1831 BF_2 3.00 0.65 480 795560696 XP_011908067.1 868 6.9e-91 PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X4 [Cercocebus atys] 649109122 KJ893951.1 480 0 Synthetic construct Homo sapiens clone ccsbBroadEn_03345 ERGIC3 gene, encodes complete protein -- -- -- -- Q9Y282 868 2.9e-92 Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Homo sapiens GN=ERGIC3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2667 COPII vesicle protein Cluster-8309.18310 BF_2 48.00 2.95 968 91084301 XP_971859.1 879 7.4e-92 PREDICTED: structure-specific endonuclease subunit slx1 [Tribolium castaneum]>gi|270008803|gb|EFA05251.1| hypothetical protein TcasGA2_TC015403 [Tribolium castaneum] -- -- -- -- -- K15078 SLX1 structure-specific endonuclease subunit SLX1 http://www.genome.jp/dbget-bin/www_bget?ko:K15078 Q0IH86 728 9.9e-76 Structure-specific endonuclease subunit slx1 OS=Xenopus laevis GN=slx1a PE=2 SV=1 PF03119//PF00628 NAD-dependent DNA ligase C4 zinc finger domain//PHD-finger GO:0006281//GO:0006260 DNA repair//DNA replication GO:0005515//GO:0003911 protein binding//DNA ligase (NAD+) activity -- -- KOG3005 GIY-YIG type nuclease Cluster-8309.18313 BF_2 10.59 0.35 1561 642928539 XP_008195366.1 428 2.4e-39 PREDICTED: trypsin-1-like [Tribolium castaneum]>gi|270011007|gb|EFA07455.1| serine protease P94 [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q91Y47 258 5.0e-21 Coagulation factor XI OS=Mus musculus GN=F11 PE=2 SV=2 PF01445//PF00089//PF07127 Viral small hydrophobic protein//Trypsin//Late nodulin protein GO:0006508//GO:0009878 proteolysis//nodule morphogenesis GO:0008236//GO:0046872//GO:0004252 serine-type peptidase activity//metal ion binding//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.18315 BF_2 29.95 0.83 1792 642937193 XP_008198733.1 1396 1.6e-151 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 1140 3.1e-123 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF00199 Catalase GO:0006979//GO:0006804//GO:0055114//GO:0006568//GO:0015947 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process//tryptophan metabolic process//methane metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.18316 BF_2 47.05 1.35 1740 642937193 XP_008198733.1 1886 2.3e-208 PREDICTED: LOW QUALITY PROTEIN: catalase-like [Tribolium castaneum] -- -- -- -- -- K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P00432 1476 3.3e-162 Catalase OS=Bos taurus GN=CAT PE=1 SV=3 PF00199 Catalase GO:0006979//GO:0006804//GO:0055114//GO:0006568//GO:0015947 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process//tryptophan metabolic process//methane metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.1832 BF_2 3.00 0.41 593 207298841 ACI23572.1 335 5.5e-29 cardiac muscle actin [Homarus americanus] 3907621 AF100987.1 132 1.07242e-60 AF100987 Penaeus monodon actin 2 (act2) mRNA, complete cds K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 O16808 325 3.3e-29 Actin OS=Mayetiola destructor PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.18322 BF_2 4.00 3.20 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18325 BF_2 6.48 0.63 720 546672740 ERL84510.1 159 1.7e-08 hypothetical protein D910_01940 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18326 BF_2 2.00 0.89 379 166919247 ABZ04021.1 206 3.2e-14 serine protease 13 [Costelytra zealandica] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P36178 182 7.9e-13 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18328 BF_2 20.00 1.57 820 795271913 XP_011857417.1 1341 1.7e-145 PREDICTED: 40S ribosomal protein S3 isoform X1 [Mandrillus leucophaeus] 378548188 NM_001005.4 820 0 Homo sapiens ribosomal protein S3 (RPS3), transcript variant 1, mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 Q0Z8U2 1240 3.6e-135 40S ribosomal protein S3 OS=Sus scrofa GN=RPS3 PE=1 SV=1 PF07650 KH domain -- -- GO:0003723 RNA binding -- -- KOG3181 40S ribosomal protein S3 Cluster-8309.18329 BF_2 113.00 4.46 1348 642914825 XP_008194954.1 764 2.2e-78 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q5XGE9 446 6.9e-43 Lipase member H OS=Xenopus tropicalis GN=liph PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18330 BF_2 32.95 3.51 680 642915056 XP_008190391.1 276 4.4e-22 PREDICTED: uncharacterized protein LOC103312182 [Tribolium castaneum]>gi|270001357|gb|EEZ97804.1| hypothetical protein TcasGA2_TC000168 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18331 BF_2 8.01 0.62 829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18334 BF_2 7.50 0.43 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18338 BF_2 209.82 3.00 3215 642920703 XP_008192529.1 303 1.5e-24 PREDICTED: beta-taxilin-like isoform X2 [Tribolium castaneum]>gi|270006091|gb|EFA02539.1| hypothetical protein TcasGA2_TC008244 [Tribolium castaneum] -- -- -- -- -- K15712 TTC3 E3 ubiquitin-protein ligase TTC3 http://www.genome.jp/dbget-bin/www_bget?ko:K15712 Q86Y13 157 5.4e-09 E3 ubiquitin-protein ligase DZIP3 OS=Homo sapiens GN=DZIP3 PE=1 SV=2 PF00097//PF14634//PF12906//PF17123//PF12678//PF11789//PF12861//PF03938//PF13639//PF04420 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Zinc-finger of the MIZ type in Nse subunit//Anaphase-promoting complex subunit 11 RING-H2 finger//Outer membrane protein (OmpH-like)//Ring finger domain//CHD5-like protein GO:0016567//GO:0071816 protein ubiquitination//tail-anchored membrane protein insertion into ER membrane GO:0004842//GO:0005515//GO:0046872//GO:0051082//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//unfolded protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.18340 BF_2 19.00 0.67 1480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18341 BF_2 3.00 0.62 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18343 BF_2 1.00 1.34 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18345 BF_2 114.56 0.89 5666 642928360 XP_972133.2 2245 1.8e-249 PREDICTED: ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [Tribolium castaneum] 768408887 XM_011551471.1 79 3.1313e-30 PREDICTED: Plutella xylostella igLON family member 5-like (LOC105381682), mRNA K05655 ABCB8 ATP-binding cassette, subfamily B (MDR/TAP), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K05655 B2GUP8 1544 1.4e-169 ATP-binding cassette sub-family B member 8, mitochondrial OS=Xenopus tropicalis GN=abcb8 PE=2 SV=1 PF06414//PF00005//PF03193//PF13895//PF00664//PF13304//PF01583//PF12814//PF06472 Zeta toxin//ABC transporter//Protein of unknown function, DUF258//Immunoglobulin domain//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Adenylylsulphate kinase//Meiotic cell cortex C-terminal pleckstrin homology//ABC transporter transmembrane region 2 GO:0006810//GO:0055085//GO:0006144//GO:0000103//GO:0032065 transport//transmembrane transport//purine nucleobase metabolic process//sulfate assimilation//cortical protein anchoring GO:0042626//GO:0016887//GO:0016301//GO:0003924//GO:0005524//GO:0005525//GO:0005543//GO:0004020//GO:0005515 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTPase activity//ATP binding//GTP binding//phospholipid binding//adenylylsulfate kinase activity//protein binding GO:0005938//GO:0016021 cell cortex//integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-8309.18347 BF_2 5.38 1.36 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18348 BF_2 214.63 1.79 5297 642930197 XP_008196297.1 6176 0.0e+00 PREDICTED: protein jagged-1b isoform X2 [Tribolium castaneum] 642930196 XM_008198075.1 758 0 PREDICTED: Tribolium castaneum protein jagged-1b (LOC652942), transcript variant X2, mRNA K06052 JAGGED jagged http://www.genome.jp/dbget-bin/www_bget?ko:K06052 Q90Y54 2958 0.0e+00 Protein jagged-1b OS=Danio rerio GN=jag1b PE=2 SV=1 PF07657//PF01414//PF00008//PF07645 N terminus of Notch ligand//Delta serrate ligand//EGF-like domain//Calcium-binding EGF domain GO:0007154//GO:0007219//GO:0007275 cell communication//Notch signaling pathway//multicellular organismal development GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.18350 BF_2 6.00 1.32 477 355691448 EHH26633.1 289 9.5e-24 hypothetical protein EGK_16652, partial [Macaca mulatta] 584458492 NG_033929.1 403 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 -- -- -- -- O00370 281 3.3e-24 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18351 BF_2 6.00 0.36 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18352 BF_2 3.00 0.88 429 91078472 XP_968116.1 163 3.5e-09 PREDICTED: probable helicase with zinc finger domain [Tribolium castaneum]>gi|270003858|gb|EFA00306.1| hypothetical protein TcasGA2_TC003141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414//PF13174//PF02025//PF13181//PF00515 TPR repeat//Tetratricopeptide repeat//Interleukin 5//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0005137//GO:0008083//GO:0005515 interleukin-5 receptor binding//growth factor activity//protein binding GO:0005576//GO:0005895 extracellular region//interleukin-5 receptor complex -- -- Cluster-8309.18353 BF_2 216.00 2.10 4583 546677353 ERL88210.1 4130 0.0e+00 hypothetical protein D910_05598, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DFV5 2628 2.3e-295 Probable helicase with zinc finger domain OS=Mus musculus GN=Helz PE=1 SV=2 PF01006//PF08405//PF08043//PF00580//PF01637//PF02562//PF00642//PF04851 Hepatitis C virus non-structural protein NS4a//Viral polyprotein N-terminal//Xin repeat//UvrD/REP helicase N-terminal domain//Archaeal ATPase//PhoH-like protein//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Type III restriction enzyme, res subunit GO:0030036//GO:0006144//GO:0016032//GO:0044419//GO:0006508 actin cytoskeleton organization//purine nucleobase metabolic process//viral process//interspecies interaction between organisms//proteolysis GO:0003779//GO:0016787//GO:0005524//GO:0003677//GO:0017111//GO:0046872//GO:0004197//GO:0003968 actin binding//hydrolase activity//ATP binding//DNA binding//nucleoside-triphosphatase activity//metal ion binding//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0019012//GO:0031379//GO:0030054 virion//RNA-directed RNA polymerase complex//cell junction KOG1804 RNA helicase Cluster-8309.18354 BF_2 12.37 0.58 1172 642923797 XP_008193887.1 184 3.5e-11 PREDICTED: uncharacterized protein LOC663689 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18355 BF_2 510.00 6.06 3805 546683413 ERL93229.1 4000 0.0e+00 hypothetical protein D910_10525 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BYA0 2403 2.3e-269 Tubulin-specific chaperone D OS=Mus musculus GN=Tbcd PE=2 SV=1 PF08429//PF02985 PLU-1-like protein//HEAT repeat GO:0055114 oxidation-reduction process GO:0005515//GO:0016706 protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- KOG1943 Beta-tubulin folding cofactor D Cluster-8309.18359 BF_2 2.00 0.82 388 478256535 ENN76719.1 363 2.0e-32 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 545833013 XM_005664905.1 45 1.57163e-12 PREDICTED: Sus scrofa zinc finger protein 71 (ZNF71), transcript variant X4, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14591 303 7.6e-27 Zinc finger protein 271 OS=Homo sapiens GN=ZNF271 PE=2 SV=4 PF00518//PF06467//PF00096//PF02892//PF00412//PF13912//PF01428//PF16622//PF05191//PF13465//PF07975 Early Protein (E6)//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C2H2 type//BED zinc finger//LIM domain//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc-finger double domain//TFIIH C1-like domain GO:0006281//GO:0006144//GO:0046034 DNA repair//purine nucleobase metabolic process//ATP metabolic process GO:0004017//GO:0046872//GO:0008270//GO:0003677 adenylate kinase activity//metal ion binding//zinc ion binding//DNA binding GO:0042025 host cell nucleus -- -- Cluster-8309.18360 BF_2 43.00 1.72 1336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.18361 BF_2 517.44 8.17 2935 576249490 AHH29251.1 2700 1.6e-302 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 2069 9.6e-231 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF01384//PF00209 Phosphate transporter family//Sodium:neurotransmitter symporter family GO:0006812//GO:0006836//GO:0006817 cation transport//neurotransmitter transport//phosphate ion transport GO:0005315//GO:0005328 inorganic phosphate transmembrane transporter activity//neurotransmitter:sodium symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.18364 BF_2 363.00 5.72 2943 556725970 XP_005958763.1 2452 9.0e-274 PREDICTED: pyruvate, phosphate dikinase 1, chloroplastic-like [Pantholops hodgsonii] 32986992 AK101783.1 2940 0 Oryza sativa Japonica Group cDNA clone:J033065A07, full insert sequence >gnl|BL_ORD_ID|1148081 Oryza sativa Japonica Group cDNA clone:J033150I16, full insert sequence -- -- -- -- Q6AVA8 4456 0.0e+00 Pyruvate, phosphate dikinase 1, chloroplastic OS=Oryza sativa subsp. japonica GN=PPDK1 PE=1 SV=1 PF01326//PF02896//PF00391 Pyruvate phosphate dikinase, PEP/pyruvate binding domain//PEP-utilising enzyme, TIM barrel domain//PEP-utilising enzyme, mobile domain GO:0016310 phosphorylation GO:0005524//GO:0016772//GO:0016301 ATP binding//transferase activity, transferring phosphorus-containing groups//kinase activity -- -- -- -- Cluster-8309.18367 BF_2 5.00 0.53 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18368 BF_2 21.00 0.31 3091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00440//PF04542 Bacterial regulatory proteins, tetR family//Sigma-70 region 2 GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0016987//GO:0003677//GO:0003700 sigma factor activity//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.18371 BF_2 12.30 0.52 1280 478263661 ENN81967.1 342 1.8e-29 hypothetical protein YQE_01678, partial [Dendroctonus ponderosae]>gi|546676699|gb|ERL87655.1| hypothetical protein D910_05046 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06703//PF05837//PF04977//PF06214 Microsomal signal peptidase 25 kDa subunit (SPC25)//Centromere protein H (CENP-H)//Septum formation initiator//Signaling lymphocytic activation molecule (SLAM) protein GO:0006465//GO:0007165//GO:0051382//GO:0046649//GO:0007049 signal peptide processing//signal transduction//kinetochore assembly//lymphocyte activation//cell cycle GO:0004872//GO:0008233 receptor activity//peptidase activity GO:0016021//GO:0005787//GO:0000776//GO:0009986 integral component of membrane//signal peptidase complex//kinetochore//cell surface -- -- Cluster-8309.18372 BF_2 178.28 5.89 1553 478263661 ENN81967.1 435 3.7e-40 hypothetical protein YQE_01678, partial [Dendroctonus ponderosae]>gi|546676699|gb|ERL87655.1| hypothetical protein D910_05046 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6NWC9 181 4.3e-12 G kinase-anchoring protein 1 OS=Danio rerio GN=gkap1 PE=2 SV=1 PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.18374 BF_2 51.60 0.63 3703 642922135 XP_008193031.1 782 5.1e-80 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 Q704S8 396 1.2e-36 Carnitine O-acetyltransferase OS=Rattus norvegicus GN=Crat PE=1 SV=1 PF07074//PF00755//PF04699 Translocon-associated protein, gamma subunit (TRAP-gamma)//Choline/Carnitine o-acyltransferase//ARP2/3 complex 16 kDa subunit (p16-Arc) GO:0034314//GO:0006613//GO:0030833 Arp2/3 complex-mediated actin nucleation//cotranslational protein targeting to membrane//regulation of actin filament polymerization GO:0016746 transferase activity, transferring acyl groups GO:0015629//GO:0005885//GO:0030176//GO:0005784 actin cytoskeleton//Arp2/3 protein complex//integral component of endoplasmic reticulum membrane//Sec61 translocon complex -- -- Cluster-8309.18376 BF_2 620.06 5.65 4878 642922135 XP_008193031.1 2247 8.8e-250 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.0e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF00755//PF04699 Choline/Carnitine o-acyltransferase//ARP2/3 complex 16 kDa subunit (p16-Arc) GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation GO:0016746 transferase activity, transferring acyl groups GO:0005885//GO:0015629 Arp2/3 protein complex//actin cytoskeleton KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18377 BF_2 104.14 0.93 4960 642922135 XP_008193031.1 2240 5.8e-249 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.1e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF04699//PF00755 ARP2/3 complex 16 kDa subunit (p16-Arc)//Choline/Carnitine o-acyltransferase GO:0034314//GO:0030833 Arp2/3 complex-mediated actin nucleation//regulation of actin filament polymerization GO:0016746 transferase activity, transferring acyl groups GO:0015629//GO:0005885 actin cytoskeleton//Arp2/3 protein complex KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.18378 BF_2 123.92 1.13 4892 642922135 XP_008193031.1 2247 8.9e-250 PREDICTED: carnitine O-acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00624 E2.3.1.7 carnitine O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00624 P52826 1298 4.0e-141 Carnitine O-acetyltransferase OS=Columba livia GN=CRAT PE=1 SV=1 PF00755//PF04699 Choline/Carnitine o-acyltransferase//ARP2/3 complex 16 kDa subunit (p16-Arc) GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation GO:0016746 transferase activity, transferring acyl groups GO:0015629//GO:0005885 actin cytoskeleton//Arp2/3 protein complex KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.1838 BF_2 4.00 0.37 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18386 BF_2 6.41 0.57 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18392 BF_2 63.00 0.62 4544 642922557 XP_008193225.1 595 3.0e-58 PREDICTED: uncharacterized protein LOC100142258 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G5E8K5 253 5.6e-20 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.18395 BF_2 12.88 6.81 363 270003816 EFA00264.1 188 3.7e-12 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01853//PF05225 MOZ/SAS family//helix-turn-helix, Psq domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0016747 DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.18397 BF_2 664.00 171.22 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18400 BF_2 212.51 5.53 1894 820805536 AKG92759.1 682 1.0e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.89606e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 5.0e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF00010//PF01586 Helix-loop-helix DNA-binding domain//Myogenic Basic domain GO:0006355//GO:0007517 regulation of transcription, DNA-templated//muscle organ development GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.18403 BF_2 85.27 6.81 811 642912538 XP_008200905.1 453 1.6e-42 PREDICTED: uncharacterized protein LOC103315037 [Tribolium castaneum]>gi|270002598|gb|EEZ99045.1| hypothetical protein TcasGA2_TC004919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18406 BF_2 556.00 12.52 2145 91082329 XP_974627.1 763 4.7e-78 PREDICTED: mannose-P-dolichol utilization defect 1 protein homolog [Tribolium castaneum]>gi|270007185|gb|EFA03633.1| hypothetical protein TcasGA2_TC013726 [Tribolium castaneum] -- -- -- -- -- K09660 MPDU1 mannose-P-dolichol utilization defect 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09660 Q9VMW8 627 1.1e-63 Mannose-P-dolichol utilization defect 1 protein homolog OS=Drosophila melanogaster GN=CG3792 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.18409 BF_2 148.94 3.24 2211 91086103 XP_967597.1 2529 8.0e-283 PREDICTED: actin-related protein 5 [Tribolium castaneum]>gi|270009896|gb|EFA06344.1| hypothetical protein TcasGA2_TC009219 [Tribolium castaneum] 462365391 APGK01027627.1 62 3.41397e-21 Dendroctonus ponderosae Seq01027637, whole genome shotgun sequence K11672 ACTR5, ARP5, INO80M actin-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11672 Q17GZ9 1557 1.7e-171 Actin-related protein 5 OS=Aedes aegypti GN=Arp5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0681 Actin-related protein - Arp5p Cluster-8309.1841 BF_2 3.00 0.86 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18410 BF_2 71.06 1.50 2272 91086103 XP_967597.1 2399 9.7e-268 PREDICTED: actin-related protein 5 [Tribolium castaneum]>gi|270009896|gb|EFA06344.1| hypothetical protein TcasGA2_TC009219 [Tribolium castaneum] -- -- -- -- -- K11672 ACTR5, ARP5, INO80M actin-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11672 Q17GZ9 1506 1.4e-165 Actin-related protein 5 OS=Aedes aegypti GN=Arp5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0681 Actin-related protein - Arp5p Cluster-8309.18411 BF_2 143.00 4.62 1583 332372598 AEE61441.1 1173 9.9e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZU82 423 3.8e-40 Golgin subfamily A member 5 OS=Rattus norvegicus GN=Golga5 PE=1 SV=1 PF15898 cGMP-dependent protein kinase interacting domain -- -- GO:0019901 protein kinase binding -- -- KOG4677 Golgi integral membrane protein Cluster-8309.18413 BF_2 5.38 1.15 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18415 BF_2 61.55 4.22 897 642912276 XP_008200634.1 634 1.8e-63 PREDICTED: exportin-7 isoform X2 [Tribolium castaneum]>gi|270002549|gb|EEZ98996.1| hypothetical protein TcasGA2_TC004857 [Tribolium castaneum] -- -- -- -- -- K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q569Z2 452 9.3e-44 Exportin-7-B OS=Xenopus laevis GN=xpo7-b PE=2 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0008536 protein transporter activity//Ran GTPase binding GO:0005643 nuclear pore KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.18416 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18418 BF_2 85.86 1.37 2900 270008674 EFA05122.1 2375 7.6e-265 hypothetical protein TcasGA2_TC015236 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 981 1.4e-104 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF01691//PF01566//PF00916 Adenovirus E1B 19K protein / small t-antigen//Natural resistance-associated macrophage protein//Sulfate permease family GO:0008272//GO:0043066//GO:0006810 sulfate transport//negative regulation of apoptotic process//transport GO:0005521//GO:0015116//GO:0005215 lamin binding//sulfate transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.18419 BF_2 310.93 5.10 2839 270008674 EFA05122.1 2410 6.5e-269 hypothetical protein TcasGA2_TC015236 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 1020 4.0e-109 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF01691//PF01566//PF03083//PF00916 Adenovirus E1B 19K protein / small t-antigen//Natural resistance-associated macrophage protein//Sugar efflux transporter for intercellular exchange//Sulfate permease family GO:0043066//GO:0006810//GO:0008272 negative regulation of apoptotic process//transport//sulfate transport GO:0005521//GO:0005215//GO:0015116 lamin binding//transporter activity//sulfate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.18422 BF_2 166.45 1.43 5149 642933323 XP_008197368.1 1156 3.0e-123 PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum]>gi|642933325|ref|XP_008197369.1| PREDICTED: cytosolic endo-beta-N-acetylglucosaminidase [Tribolium castaneum] -- -- -- -- -- K01227 E3.2.1.96 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01227 Q8BX80 668 4.8e-68 Cytosolic endo-beta-N-acetylglucosaminidase OS=Mus musculus GN=Engase PE=2 SV=1 PF03644 Glycosyl hydrolase family 85 -- -- GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2331 Predicted glycosylhydrolase Cluster-8309.18423 BF_2 104.56 10.80 692 91084789 XP_972673.1 588 2.9e-58 PREDICTED: 6-pyruvoyl tetrahydrobiopterin synthase [Tribolium castaneum]>gi|270008955|gb|EFA05403.1| hypothetical protein TcasGA2_TC015575 [Tribolium castaneum] -- -- -- -- -- K01737 queD, ptpS, PTS 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01737 P48611 436 5.1e-42 6-pyruvoyl tetrahydrobiopterin synthase OS=Drosophila melanogaster GN=pr PE=1 SV=1 -- -- GO:0046656//GO:0006729 folic acid biosynthetic process//tetrahydrobiopterin biosynthetic process GO:0003874//GO:0046872 6-pyruvoyltetrahydropterin synthase activity//metal ion binding -- -- KOG4105 6-pyruvoyl tetrahydrobiopterin synthase Cluster-8309.18425 BF_2 409.50 5.21 3578 91095075 XP_972860.1 3860 0.0e+00 PREDICTED: small G protein signaling modulator 3 homolog isoform X2 [Tribolium castaneum]>gi|270014751|gb|EFA11199.1| hypothetical protein TcasGA2_TC005163 [Tribolium castaneum] 820846062 XM_012485562.1 519 0 PREDICTED: Apis florea small G protein signaling modulator 3 homolog (LOC100867963), mRNA -- -- -- -- A6H8I2 2747 2.8e-309 Small G protein signaling modulator 3 homolog OS=Xenopus laevis GN=sgsm3 PE=2 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding GO:0005622 intracellular KOG2058 Ypt/Rab GTPase activating protein Cluster-8309.18428 BF_2 125.32 1.09 5116 642911263 XP_008199814.1 2052 3.8e-227 PREDICTED: small G protein signaling modulator 3 homolog isoform X1 [Tribolium castaneum]>gi|642911265|ref|XP_008199821.1| PREDICTED: small G protein signaling modulator 3 homolog isoform X1 [Tribolium castaneum] 820846062 XM_012485562.1 179 7.26753e-86 PREDICTED: Apis florea small G protein signaling modulator 3 homolog (LOC100867963), mRNA -- -- -- -- A6H8I2 1331 6.3e-145 Small G protein signaling modulator 3 homolog OS=Xenopus laevis GN=sgsm3 PE=2 SV=1 PF04494//PF00400 WD40 associated region in TFIID subunit, NTD2 domain//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.18431 BF_2 148.20 2.09 3249 91077726 XP_975075.1 2486 1.1e-277 PREDICTED: protein inturned [Tribolium castaneum]>gi|270002215|gb|EEZ98662.1| hypothetical protein TcasGA2_TC001193 [Tribolium castaneum] 642914358 XM_969982.2 79 1.78701e-30 PREDICTED: Tribolium castaneum protein inturned (LOC663956), mRNA -- -- -- -- F6U5F9 822 4.2e-86 Protein inturned OS=Xenopus tropicalis GN=intu PE=3 SV=1 PF03276//PF15281 Spumavirus gag protein//Consortin C-terminus GO:0046718//GO:0042998//GO:0075521//GO:0019076 viral entry into host cell//positive regulation of Golgi to plasma membrane protein transport//microtubule-dependent intracellular transport of viral material towards nucleus//viral release from host cell GO:0071253 connexin binding GO:0019028//GO:0042025//GO:0005802//GO:0044163//GO:0030430 viral capsid//host cell nucleus//trans-Golgi network//host cytoskeleton//host cell cytoplasm -- -- Cluster-8309.18434 BF_2 29.22 0.96 1566 642931629 XP_008196662.1 965 1.3e-101 PREDICTED: broad-complex core protein isoform 6-like isoform X4 [Tribolium castaneum] -- -- -- -- -- K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P42282 347 2.4e-31 Protein tramtrack, alpha isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=3 PF13912//PF02892//PF00651//PF00096//PF13465 C2H2-type zinc finger//BED zinc finger//BTB/POZ domain//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.18435 BF_2 15.00 1.47 713 82795519 ABB91673.1 400 1.9e-36 arthrodial cuticle protein AMP9.3 [Callinectes sapidus] 82795518 DQ288148.1 336 5.15046e-174 Callinectes sapidus arthrodial cuticle protein AMP9.3 mRNA, complete cds -- -- -- -- P81388 205 3.2e-15 Cuticle protein AMP4 OS=Homarus americanus PE=1 SV=1 PF02048//PF00379 Heat-stable enterotoxin ST//Insect cuticle protein GO:0009405 pathogenesis GO:0042302 structural constituent of cuticle GO:0005576 extracellular region -- -- Cluster-8309.18437 BF_2 55.69 0.44 5609 642938156 XP_969509.2 657 2.4e-65 PREDICTED: cleavage and polyadenylation specificity factor subunit 5 [Tribolium castaneum] 696970323 XM_009557133.1 59 4.06672e-19 PREDICTED: Cuculus canorus nudix (nucleoside diphosphate linked moiety X)-type motif 21 (NUDT21), mRNA K14397 NUDT21, CPSF5, CFIM25 cleavage and polyadenylation specificity factor subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14397 Q7T3C6 466 1.4e-44 Cleavage and polyadenylation specificity factor subunit 5 OS=Danio rerio GN=cpsf5 PE=2 SV=1 PF00293//PF13869 NUDIX domain//Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729 hydrolase activity//mRNA binding GO:0005849 mRNA cleavage factor complex KOG1689 mRNA cleavage factor I subunit Cluster-8309.18438 BF_2 4.17 0.46 667 642938156 XP_969509.2 231 7.1e-17 PREDICTED: cleavage and polyadenylation specificity factor subunit 5 [Tribolium castaneum] -- -- -- -- -- K14397 NUDT21, CPSF5, CFIM25 cleavage and polyadenylation specificity factor subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14397 Q3ZCA2 197 2.5e-14 Cleavage and polyadenylation specificity factor subunit 5 OS=Bos taurus GN=NUDT21 PE=2 SV=1 PF13869 Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0003729 mRNA binding GO:0005849 mRNA cleavage factor complex KOG1689 mRNA cleavage factor I subunit Cluster-8309.18439 BF_2 392.37 14.58 1413 642938156 XP_969509.2 1206 1.3e-129 PREDICTED: cleavage and polyadenylation specificity factor subunit 5 [Tribolium castaneum] 696970323 XM_009557133.1 122 9.57269e-55 PREDICTED: Cuculus canorus nudix (nucleoside diphosphate linked moiety X)-type motif 21 (NUDT21), mRNA K14397 NUDT21, CPSF5, CFIM25 cleavage and polyadenylation specificity factor subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14397 Q7T3C6 943 1.7e-100 Cleavage and polyadenylation specificity factor subunit 5 OS=Danio rerio GN=cpsf5 PE=2 SV=1 PF00293//PF13869 NUDIX domain//Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0016787//GO:0003729 hydrolase activity//mRNA binding GO:0005849 mRNA cleavage factor complex KOG1689 mRNA cleavage factor I subunit Cluster-8309.18441 BF_2 13.00 1.05 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- -- -- Cluster-8309.18442 BF_2 65.00 1.34 2315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04647 Accessory gene regulator B GO:0009372//GO:0009405 quorum sensing//pathogenesis GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.18444 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18445 BF_2 226.00 3.73 2825 91081769 XP_973294.1 1556 6.8e-170 PREDICTED: leucine-rich repeat-containing protein 24 [Tribolium castaneum]>gi|270006275|gb|EFA02723.1| hypothetical protein TcasGA2_TC008448 [Tribolium castaneum] 642921390 XM_968234.2 171 1.11724e-81 PREDICTED: Tribolium castaneum leucine-rich repeat-containing protein 24 (LOC662117), mRNA -- -- -- -- Q50LG9 330 4.1e-29 Leucine-rich repeat-containing protein 24 OS=Homo sapiens GN=LRRC24 PE=2 SV=2 PF00560//PF13855//PF13895 Leucine Rich Repeat//Leucine rich repeat//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18446 BF_2 7.13 0.83 648 328698759 XP_003240725.1 582 1.4e-57 PREDICTED: serine/arginine repetitive matrix protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18450 BF_2 2.00 1.92 321 170068163 XP_001868759.1 349 7.0e-31 conserved hypothetical protein [Culex quinquefasciatus]>gi|167864268|gb|EDS27651.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase GO:0051191 prosthetic group biosynthetic process -- -- -- -- -- -- Cluster-8309.18452 BF_2 1.00 0.42 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00367 phosphotransferase system, EIIB GO:0008643 carbohydrate transport GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.18455 BF_2 14.19 0.50 1481 546673719 ERL85275.1 1353 1.2e-146 hypothetical protein D910_02696 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96I51 932 3.4e-99 Williams-Beuren syndrome chromosomal region 16 protein OS=Homo sapiens GN=WBSCR16 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.18458 BF_2 12.00 0.61 1108 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18459 BF_2 33.74 1.01 1679 270297198 NP_001161920.1 185 3.9e-11 peritrophic matrix protein 2-B precursor [Tribolium castaneum]>gi|268309034|gb|ACY95483.1| peritrophic matrix protein 2-B [Tribolium castaneum]>gi|270003976|gb|EFA00424.1| hypothetical protein TcasGA2_TC003275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.18460 BF_2 27.03 1.39 1098 642930142 XP_008196269.1 1167 3.4e-125 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X3 [Tribolium castaneum] 189164165 EU545256.1 263 3.07181e-133 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 876 7.7e-93 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.18461 BF_2 1.00 0.48 372 478263248 ENN81636.1 231 4.0e-17 hypothetical protein YQE_01967, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18464 BF_2 144.00 3.30 2111 641672628 XP_008186016.1 253 6.3e-19 PREDICTED: uncharacterized protein LOC100164223 isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q9SDW0 164 5.4e-10 Trihelix transcription factor GT-3a OS=Arabidopsis thaliana GN=GT-3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18465 BF_2 21.02 0.33 2979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18467 BF_2 2.00 0.69 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16952 Glutamine synthetase N-terminal domain GO:0006542//GO:0009252//GO:0006807 glutamine biosynthetic process//peptidoglycan biosynthetic process//nitrogen compound metabolic process GO:0004356 glutamate-ammonia ligase activity -- -- -- -- Cluster-8309.18468 BF_2 4.00 0.65 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00598 Influenza Matrix protein (M1) -- -- GO:0005198//GO:0003723 structural molecule activity//RNA binding -- -- -- -- Cluster-8309.18469 BF_2 175.33 3.23 2561 189235703 XP_001807591.1 3233 0.0e+00 PREDICTED: CAS1 domain-containing protein 1 [Tribolium castaneum] 642917634 XM_001807539.2 82 3.02062e-32 PREDICTED: Tribolium castaneum CAS1 domain-containing protein 1 (LOC655926), mRNA -- -- -- -- Q96PB1 1444 2.5e-158 CAS1 domain-containing protein 1 OS=Homo sapiens GN=CASD1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1699 O-acetyltransferase Cluster-8309.18471 BF_2 30.00 1.93 937 -- -- -- -- -- 761231605 KM881639.1 932 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18472 BF_2 8.00 0.57 870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18474 BF_2 23.40 0.52 2187 642913117 XP_008201398.1 1590 6.0e-174 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.5e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18478 BF_2 36.64 0.59 2893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18479 BF_2 6.70 0.44 928 646702024 KDR11468.1 420 1.2e-38 Sodium-driven chloride bicarbonate exchanger [Zootermopsis nevadensis] -- -- -- -- -- K13861 SLC4A10, NCBE solute carrier family 4 (sodium bicarbonate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13861 Q8BTY2 220 7.6e-17 Sodium bicarbonate cotransporter 3 OS=Mus musculus GN=Slc4a7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.18480 BF_2 3.00 6.64 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18483 BF_2 6.00 0.39 924 332373670 AEE61976.1 280 2.0e-22 unknown [Dendroctonus ponderosae]>gi|478257673|gb|ENN77820.1| hypothetical protein YQE_05704, partial [Dendroctonus ponderosae] -- -- -- -- -- K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q9GZP9 239 4.8e-19 Derlin-2 OS=Homo sapiens GN=DERL2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.1849 BF_2 9.00 0.39 1247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18490 BF_2 1.00 0.42 384 861588173 KMQ82585.1 262 1.0e-20 transposase-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18492 BF_2 94.00 2.95 1622 642922343 XP_973628.2 1218 6.1e-131 PREDICTED: heparin sulfate O-sulfotransferase [Tribolium castaneum] -- -- -- -- -- K02513 HS2ST1 heparan sulfate 2-O-sulfotransferase HS2ST1 http://www.genome.jp/dbget-bin/www_bget?ko:K02513 P25722 1014 1.1e-108 Heparin sulfate O-sulfotransferase OS=Drosophila melanogaster GN=Hs2st PE=2 SV=2 PF03567//PF06990//PF00685 Sulfotransferase family//Galactose-3-O-sulfotransferase//Sulfotransferase domain GO:0006687//GO:0009058 glycosphingolipid metabolic process//biosynthetic process GO:0001733//GO:0008146 galactosylceramide sulfotransferase activity//sulfotransferase activity GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3922 Sulfotransferases Cluster-8309.18493 BF_2 3.00 1.42 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18495 BF_2 10.62 1.77 538 728418383 AIY68367.1 330 1.9e-28 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18497 BF_2 5.00 0.44 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18498 BF_2 61.11 1.13 2544 189237970 XP_001811996.1 1195 4.5e-128 PREDICTED: protein EMSY [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZUV7 374 2.9e-34 Protein EMSY OS=Danio rerio GN=emsy PE=2 SV=1 PF12905 Endo-alpha-N-acetylgalactosaminidase -- -- GO:0033926 glycopeptide alpha-N-acetylgalactosaminidase activity -- -- -- -- Cluster-8309.1850 BF_2 2.00 0.52 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18502 BF_2 3.69 0.34 741 91094767 XP_967707.1 494 2.5e-47 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P80457 319 2.0e-28 Xanthine dehydrogenase/oxidase OS=Bos taurus GN=XDH PE=1 SV=4 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0046872//GO:0051536 oxidoreductase activity//metal ion binding//iron-sulfur cluster binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.18505 BF_2 30.06 0.56 2550 826414788 XP_012522091.1 1066 4.1e-113 PREDICTED: calpain-A isoform X2 [Monomorium pharaonis] 805805104 XM_003705388.2 60 5.10426e-20 PREDICTED: Megachile rotundata calpain-A (LOC100882339), transcript variant X9, mRNA K03853 CAPN2 calpain-2 http://www.genome.jp/dbget-bin/www_bget?ko:K03853 Q11002 1017 8.0e-109 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF00648//PF13202//PF12763//PF13405//PF00036//PF13833//PF13499 Calpain family cysteine protease//EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF hand//EF-hand domain pair//EF-hand domain pair GO:0006508 proteolysis GO:0005509//GO:0005515//GO:0004198 calcium ion binding//protein binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.18508 BF_2 407.00 10.99 1836 189234437 XP_966363.2 1791 2.5e-197 PREDICTED: BTB/POZ domain-containing protein 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GLJ1 320 3.8e-28 BTB/POZ domain-containing protein 17 OS=Xenopus laevis GN=btbd17 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18515 BF_2 27.90 0.53 2481 642923899 XP_008193920.1 1187 3.7e-127 PREDICTED: calcitonin gene-related peptide type 1 receptor-like [Tribolium castaneum]>gi|270008144|gb|EFA04592.1| hypothetical protein TcasGA2_TC013321 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08893 501 5.3e-49 Calcitonin receptor OS=Cavia porcellus GN=CALCR PE=2 SV=1 PF02793//PF00002 Hormone receptor domain//7 transmembrane receptor (Secretin family) GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004930//GO:0004888 G-protein coupled receptor activity//transmembrane signaling receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.18517 BF_2 93.00 5.40 1007 546686182 ERL95562.1 496 2.0e-47 hypothetical protein D910_12823 [Dendroctonus ponderosae] -- -- -- -- -- K07432 ALG13 beta-1,4-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07432 Q5I0K7 308 5.2e-27 UDP-N-acetylglucosamine transferase subunit ALG13 homolog OS=Rattus norvegicus GN=Alg13 PE=1 SV=1 PF04101 Glycosyltransferase family 28 C-terminal domain -- -- GO:0016758 transferase activity, transferring hexosyl groups -- -- KOG3349 Predicted glycosyltransferase Cluster-8309.18520 BF_2 9.00 0.91 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18525 BF_2 4.00 5.06 306 546686701 ERL95808.1 176 7.7e-11 hypothetical protein D910_00344, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18534 BF_2 26.00 0.57 2196 270003336 EEZ99783.1 545 9.1e-53 hypothetical protein TcasGA2_TC002562 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P19488 397 5.4e-37 UDP-glucuronosyltransferase 2B37 OS=Rattus norvegicus GN=Ugt2b37 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.18536 BF_2 89.78 2.03 2133 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04472//PF01442 Protein of unknown function (DUF552)//Apolipoprotein A1/A4/E domain GO:0000917//GO:0006869//GO:0042157 barrier septum assembly//lipid transport//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.18537 BF_2 7.00 0.81 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18540 BF_2 18.11 0.54 1686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18541 BF_2 6.00 23.13 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18544 BF_2 114.00 3.99 1482 642915350 XP_008190583.1 180 1.3e-10 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145//PF09008//PF02176//PF07967 Seven in absentia protein family//Head binding//TRAF-type zinc finger//C3HC zinc finger-like GO:0007275//GO:0006511//GO:0009405 multicellular organismal development//ubiquitin-dependent protein catabolic process//pathogenesis GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.18548 BF_2 3.00 0.99 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18549 BF_2 66.21 1.92 1733 642931509 XP_968544.2 855 8.1e-89 PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum]>gi|642931511|ref|XP_008196616.1| PREDICTED: enoyl-CoA hydratase domain-containing protein 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DC8 691 3.5e-71 Enoyl-CoA hydratase domain-containing protein 3, mitochondrial OS=Homo sapiens GN=ECHDC3 PE=1 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.18550 BF_2 26.87 0.37 3337 91080139 XP_968438.1 3370 0.0e+00 PREDICTED: polyphosphoinositide phosphatase [Tribolium castaneum]>gi|270005661|gb|EFA02109.1| hypothetical protein TcasGA2_TC007753 [Tribolium castaneum] 755878609 XM_005184732.2 66 3.09401e-23 PREDICTED: Musca domestica polyphosphoinositide phosphatase (LOC101887510), mRNA -- -- -- -- Q91WF7 1979 3.0e-220 Polyphosphoinositide phosphatase OS=Mus musculus GN=Fig4 PE=1 SV=1 PF02383 SacI homology domain -- -- GO:0042578 phosphoric ester hydrolase activity -- -- KOG1888 Putative phosphoinositide phosphatase Cluster-8309.18553 BF_2 1.00 0.49 370 328719940 XP_003246904.1 155 2.5e-08 PREDICTED: uncharacterized protein LOC100573610 [Acyrthosiphon pisum]>gi|641675813|ref|XP_008187176.1| PREDICTED: uncharacterized protein LOC100570164 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04881 Adenovirus GP19K GO:0050690 regulation of defense response to virus by virus GO:0005537 mannose binding -- -- -- -- Cluster-8309.18554 BF_2 165.31 5.13 1634 642912701 XP_970424.2 1272 3.4e-137 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 444 1.4e-42 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.18555 BF_2 200.00 6.10 1658 91076528 XP_973650.1 1936 3.5e-214 PREDICTED: U3 small nucleolar RNA-associated protein 15 homolog [Tribolium castaneum]>gi|270002401|gb|EEZ98848.1| hypothetical protein TcasGA2_TC004458 [Tribolium castaneum] -- -- -- -- -- K14549 UTP15 U3 small nucleolar RNA-associated protein 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14549 A7MB12 1017 5.2e-109 U3 small nucleolar RNA-associated protein 15 homolog OS=Bos taurus GN=UTP15 PE=2 SV=1 PF00400//PF09384 WD domain, G-beta repeat//UTP15 C terminal GO:0006364 rRNA processing GO:0005515 protein binding GO:0005730 nucleolus KOG0310 Conserved WD40 repeat-containing protein Cluster-8309.18557 BF_2 141.00 6.77 1159 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF00097//PF17122//PF17123//PF12678//PF14634//PF12861 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.18558 BF_2 3.96 0.41 690 478255213 ENN75442.1 378 6.6e-34 hypothetical protein YQE_07993, partial [Dendroctonus ponderosae] -- -- -- -- -- K00953 FLAD1 FAD synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00953 Q68EH8 210 8.2e-16 FAD synthase OS=Danio rerio GN=flad1 PE=2 SV=1 PF06925 Monogalactosyldiacylglycerol (MGDG) synthase GO:0009247 glycolipid biosynthetic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.18561 BF_2 21.00 4.33 490 91083079 XP_968058.1 189 3.9e-12 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270007662|gb|EFA04110.1| hypothetical protein TcasGA2_TC014348 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006687//GO:0046486//GO:0005975//GO:0006012//GO:0006027 glycosphingolipid metabolic process//glycerolipid metabolic process//carbohydrate metabolic process//galactose metabolic process//glycosaminoglycan catabolic process GO:0043169//GO:0004565 cation binding//beta-galactosidase activity GO:0009341 beta-galactosidase complex -- -- Cluster-8309.18563 BF_2 98.15 1.08 4075 642918805 XP_008191593.1 2427 9.9e-271 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 1598 5.5e-176 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0208 Cation transport ATPase Cluster-8309.18570 BF_2 60.88 1.17 2463 546680809 ERL91015.1 1217 1.2e-130 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1134 2.1e-122 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.18571 BF_2 32.34 1.13 1485 642915229 XP_008190531.1 1158 5.1e-124 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 676 1.6e-69 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18572 BF_2 6.00 1.43 462 697651821 BAP75920.1 315 8.9e-27 CUX1-RET fusion protein variant c [Homo sapiens] 336042955 JF276429.1 462 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 268 1.0e-22 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18573 BF_2 2.00 24.64 228 339776 AAB59367.1 269 9.4e-22 ORF1 codes for a 40 kDa product [Homo sapiens] 12330737 AL157761.8 202 4.59933e-100 Human DNA sequence from clone RP11-131F1 on chromosome 13, complete sequence -- -- -- -- Q9UN81 265 1.1e-22 LINE-1 retrotransposable element ORF1 protein OS=Homo sapiens GN=L1RE1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18575 BF_2 16.00 0.34 2260 270001480 EEZ97927.1 322 6.7e-27 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18577 BF_2 66.12 1.59 2025 167004254 NP_001107793.1 1029 6.3e-109 empty spiracles [Tribolium castaneum]>gi|162793850|emb|CAP58696.1| empty spiracles [Tribolium castaneum]>gi|270014246|gb|EFA10694.1| empty spiracles [Tribolium castaneum] 242276439 GQ214558.1 53 3.14432e-16 Petromyzon marinus EmxB mRNA, partial cds K09317 EMX homeobox protein EMX http://www.genome.jp/dbget-bin/www_bget?ko:K09317 P18488 471 1.3e-45 Homeotic protein empty spiracles OS=Drosophila melanogaster GN=ems PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- KOG0843 Transcription factor EMX1 and related HOX domain proteins Cluster-8309.18578 BF_2 3.00 0.36 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF02176//PF08273//PF05191//PF02892 Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc-binding domain of primase-helicase//Adenylate kinase, active site lid//BED zinc finger GO:0006269//GO:0046034//GO:0006144//GO:0006351 DNA replication, synthesis of RNA primer//ATP metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0004017//GO:0008270//GO:0004386//GO:0003677//GO:0003896 metal ion binding//adenylate kinase activity//zinc ion binding//helicase activity//DNA binding//DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork -- -- Cluster-8309.18581 BF_2 93.78 9.26 711 91081577 XP_975228.1 353 5.4e-31 PREDICTED: maltase 2 [Tribolium castaneum]>gi|270006189|gb|EFA02637.1| hypothetical protein TcasGA2_TC008358 [Tribolium castaneum] 153912708 AK281733.1 34 3.90337e-06 Gryllus bimaculatus mRNA, GBcontig28594 K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 O16099 274 3.2e-23 Maltase 2 OS=Drosophila virilis GN=Mal-B2 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18582 BF_2 22.36 4.48 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18583 BF_2 2.00 1.14 357 591353318 XP_007071023.1 158 1.1e-08 PREDICTED: microfibril-associated glycoprotein 4-like [Chelonia mydas] -- -- -- -- -- -- -- -- -- P55083 153 1.7e-09 Microfibril-associated glycoprotein 4 OS=Homo sapiens GN=MFAP4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18584 BF_2 100.23 4.89 1144 642915333 XP_008190576.1 289 2.3e-23 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55918 226 1.9e-17 Microfibril-associated glycoprotein 4 OS=Bos taurus GN=MFAP4 PE=1 SV=2 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.18587 BF_2 184.10 3.76 2333 91087517 XP_969270.1 1320 1.3e-142 PREDICTED: phosphatidylinositol glycan anchor biosynthesis class U protein [Tribolium castaneum]>gi|270010669|gb|EFA07117.1| hypothetical protein TcasGA2_TC010108 [Tribolium castaneum] -- -- -- -- -- K05293 PIGU phosphatidylinositol glycan, class U http://www.genome.jp/dbget-bin/www_bget?ko:K05293 Q9H490 702 2.5e-72 Phosphatidylinositol glycan anchor biosynthesis class U protein OS=Homo sapiens GN=PIGU PE=1 SV=3 PF06728 GPI transamidase subunit PIG-U GO:0006506 GPI anchor biosynthetic process -- -- GO:0016021//GO:0044425 integral component of membrane//membrane part KOG2552 Major facilitator superfamily permease - Cdc91p Cluster-8309.18589 BF_2 378.00 13.44 1464 546685810 ERL95253.1 758 1.2e-77 hypothetical protein D910_12520 [Dendroctonus ponderosae] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q3KQG9 530 1.4e-52 Testicular acid phosphatase homolog OS=Xenopus laevis GN=acpt PE=2 SV=1 PF02257//PF00328 RFX DNA-binding domain//Histidine phosphatase superfamily (branch 2) GO:0006355//GO:0006771//GO:0019497 regulation of transcription, DNA-templated//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0003677 acid phosphatase activity//DNA binding -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.18591 BF_2 481.00 12.36 1915 189241276 XP_974567.2 1749 1.9e-192 PREDICTED: guanine nucleotide-binding protein-like 3 homolog [Tribolium castaneum]>gi|270014031|gb|EFA10479.1| hypothetical protein TcasGA2_TC012725 [Tribolium castaneum] -- -- -- -- -- K14538 NUG1, GNL3 nuclear GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14538 Q8MT06 1163 7.1e-126 Guanine nucleotide-binding protein-like 3 homolog OS=Drosophila melanogaster GN=Ns1 PE=1 SV=2 PF01926//PF08477//PF03193//PF00025//PF02421 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0005525//GO:0015093 GTPase activity//GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG2484 GTPase Cluster-8309.18592 BF_2 5.00 0.65 607 546672787 ERL84543.1 201 1.9e-13 hypothetical protein D910_01973 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18595 BF_2 578.83 31.99 1044 91087585 XP_971866.1 401 2.2e-36 PREDICTED: signal peptidase complex subunit 1 [Tribolium castaneum]>gi|270010698|gb|EFA07146.1| hypothetical protein TcasGA2_TC010137 [Tribolium castaneum] -- -- -- -- -- K12946 SPCS1 signal peptidase complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12946 Q9VAL0 285 2.5e-24 Signal peptidase complex subunit 1 OS=Drosophila melanogaster GN=Spase12 PE=1 SV=2 PF06645 Microsomal signal peptidase 12 kDa subunit (SPC12) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG4112 Signal peptidase subunit Cluster-8309.18596 BF_2 80.26 2.01 1954 332373444 AEE61863.1 830 7.2e-86 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 698 6.0e-72 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF13241//PF01266//PF03435//PF01134//PF02558//PF00056//PF00070//PF00899//PF03721//PF01494//PF07992//PF02737//PF02254 Putative NAD(P)-binding//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ThiF family//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//TrkA-N domain GO:0006574//GO:0006550//GO:0015940//GO:0006568//GO:0006554//GO:0006779//GO:0008033//GO:0055114//GO:0018874//GO:0006633//GO:0019354//GO:0006813//GO:0006631//GO:0006552 valine catabolic process//isoleucine catabolic process//pantothenate biosynthetic process//tryptophan metabolic process//lysine catabolic process//porphyrin-containing compound biosynthetic process//tRNA processing//oxidation-reduction process//benzoate metabolic process//fatty acid biosynthetic process//siroheme biosynthetic process//potassium ion transport//fatty acid metabolic process//leucine catabolic process GO:0071949//GO:0016616//GO:0003857//GO:0043115//GO:0016491//GO:0051287//GO:0008677//GO:0050660//GO:0008641 FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//precorrin-2 dehydrogenase activity//oxidoreductase activity//NAD binding//2-dehydropantoate 2-reductase activity//flavin adenine dinucleotide binding//small protein activating enzyme activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.18610 BF_2 41.60 0.43 4356 642932284 XP_008197048.1 1625 1.1e-177 PREDICTED: lysosomal alpha-mannosidase-like [Tribolium castaneum]>gi|270012319|gb|EFA08767.1| hypothetical protein TcasGA2_TC006455 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q8VHC8 1051 1.6e-112 Lysosomal alpha-mannosidase OS=Cavia porcellus GN=MAN2B1 PE=1 SV=1 PF04805//PF07748//PF01074//PF09261 E10-like protein conserved region//Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain//Alpha mannosidase, middle domain GO:0055114//GO:0006013//GO:0005975 oxidation-reduction process//mannose metabolic process//carbohydrate metabolic process GO:0008270//GO:0005488//GO:0016972//GO:0004553//GO:0004559//GO:0015923 zinc ion binding//binding//thiol oxidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.18611 BF_2 14.00 0.87 958 328697481 XP_003240351.1 529 2.8e-51 PREDICTED: uncharacterized protein LOC100573963 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P34257 141 1.1e-07 Transposable element Tc3 transposase OS=Caenorhabditis elegans GN=tc3a PE=1 SV=1 PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.18613 BF_2 80.00 0.96 3775 478261751 ENN80898.1 1556 9.1e-170 hypothetical protein YQE_02686, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18614 BF_2 2.00 1.36 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18617 BF_2 127.00 2.88 2130 270004661 EFA01109.1 205 2.3e-13 hypothetical protein TcasGA2_TC004034 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1862 BF_2 46.00 2.54 1044 155966234 ABU41071.1 1492 6.7e-163 receptor for activated protein kinase C-like protein [Lepeophtheirus salmonis]>gi|225711916|gb|ACO11804.1| Guanine nucleotide-binding protein subunit beta-like protein [Lepeophtheirus salmonis]>gi|290562157|gb|ADD38475.1| Guanine nucleotide-binding protein subunit beta-like protein [Lepeophtheirus salmonis] 656365360 KJ652971.1 1035 0 Scylla paramamosain receptor for activated protein kinase C1 mRNA, complete cds K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1400 1.3e-153 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat GO:0016310 phosphorylation GO:0005515//GO:0016301 protein binding//kinase activity -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.18620 BF_2 46.00 1.44 1621 507662015 XP_004706482.1 1546 5.7e-169 PREDICTED: 1,4-alpha-glucan-branching enzyme [Echinops telfairi] 115446458 NM_001053544.1 1621 0 Oryza sativa Japonica Group Os02g0528200 (Os02g0528200) mRNA, complete cds K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q08047 2301 6.6e-258 1,4-alpha-glucan-branching enzyme 2, chloroplastic/amyloplastic OS=Zea mays GN=SBE1 PE=1 SV=1 PF02806//PF00128 Alpha amylase, C-terminal all-beta domain//Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169 catalytic activity//cation binding -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-8309.18624 BF_2 59.21 1.01 2751 642913566 XP_008201065.1 2843 0.0e+00 PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913568|ref|XP_008201066.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913570|ref|XP_008201067.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum]>gi|642913572|ref|XP_008201068.1| PREDICTED: monocarboxylate transporter 12-like [Tribolium castaneum] 642913571 XM_008202846.1 666 0 PREDICTED: Tribolium castaneum monocarboxylate transporter 12-like (LOC661034), transcript variant X4, mRNA -- -- -- -- Q6GM59 293 7.8e-25 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.18625 BF_2 116.83 2.93 1955 501296544 BAN20989.1 1310 1.6e-141 tyrosyl-tRNA synthetase [Riptortus pedestris] -- -- -- -- -- K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q6TGS6 1236 2.5e-134 Tyrosine--tRNA ligase, cytoplasmic OS=Danio rerio GN=yars PE=2 SV=2 PF00579//PF01588 tRNA synthetases class I (W and Y)//Putative tRNA binding domain GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812//GO:0000049 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity//tRNA binding -- -- KOG2144 Tyrosyl-tRNA synthetase, cytoplasmic Cluster-8309.18629 BF_2 22.00 1.49 903 91084707 XP_969633.1 750 6.3e-77 PREDICTED: probable cytochrome P450 6a23 [Tribolium castaneum]>gi|270009245|gb|EFA05693.1| cytochrome P450 6BK13 [Tribolium castaneum] 195382034 XM_002049702.1 36 3.87327e-07 Drosophila virilis GJ20586 (Dvir\GJ20586), mRNA K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 519 1.6e-51 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0046872//GO:0005506//GO:0016491//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//metal ion binding//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-8309.18630 BF_2 42.59 0.39 4818 91092828 XP_968011.1 3111 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 4 [Tribolium castaneum]>gi|270004790|gb|EFA01238.1| gluon [Tribolium castaneum] -- -- -- -- -- K06675 SMC4 structural maintenance of chromosome 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06675 P50532 2145 2.4e-239 Structural maintenance of chromosomes protein 4 OS=Xenopus laevis GN=smc4 PE=1 SV=1 PF06160//PF13304//PF00955//PF00005//PF06470 Septation ring formation regulator, EzrA//AAA domain, putative AbiEii toxin, Type IV TA system//HCO3- transporter family//ABC transporter//SMC proteins Flexible Hinge Domain GO:0006820//GO:0006259//GO:0000921//GO:0051276 anion transport//DNA metabolic process//septin ring assembly//chromosome organization GO:0016887//GO:0005515//GO:0005524 ATPase activity//protein binding//ATP binding GO:0005694//GO:0005940//GO:0016021 chromosome//septin ring//integral component of membrane KOG0996 Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) Cluster-8309.18631 BF_2 61.38 0.69 4003 91084191 XP_967340.1 2840 0.0e+00 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270008779|gb|EFA05227.1| hypothetical protein TcasGA2_TC015371 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 2117 3.5e-236 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF05834//PF07992//PF10399//PF05199 GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//GMC oxidoreductase GO:0006563//GO:0006066//GO:0006119//GO:0006118//GO:0016117//GO:0006566//GO:0055114//GO:0006544//GO:0015992 L-serine metabolic process//alcohol metabolic process//oxidative phosphorylation//obsolete electron transport//carotenoid biosynthetic process//threonine metabolic process//oxidation-reduction process//glycine metabolic process//proton transport GO:0016614//GO:0016705//GO:0008121//GO:0016491//GO:0008812//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.18633 BF_2 6.00 0.38 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18638 BF_2 173.75 2.34 3396 642922142 XP_970966.2 2366 9.8e-264 PREDICTED: uncharacterized protein LOC659581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05817//PF01663//PF00884 Oligosaccharyltransferase subunit Ribophorin II//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0006487//GO:0008152 protein N-linked glycosylation//metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity GO:0008250//GO:0016021 oligosaccharyltransferase complex//integral component of membrane -- -- Cluster-8309.18641 BF_2 209.07 4.74 2134 642931074 XP_974160.2 683 8.8e-69 PREDICTED: stimulator of interferon genes protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TBT3 199 4.8e-14 Stimulator of interferon genes protein OS=Mus musculus GN=Tmem173 PE=1 SV=2 PF15009 Transmembrane protein 173 GO:0032481//GO:0002218 positive regulation of type I interferon production//activation of innate immune response -- -- -- -- -- -- Cluster-8309.18643 BF_2 17.64 0.67 1395 801399331 XP_012060168.1 186 2.5e-11 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18647 BF_2 13.00 1.03 816 568258029 ETN66225.1 279 2.4e-22 ubiquinol-cytochrome c reductase complex 14 kDa protein [Anopheles darlingi] -- -- -- -- -- K00417 QCR7, UQCRB ubiquinol-cytochrome c reductase subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00417 P00129 236 9.4e-19 Cytochrome b-c1 complex subunit 7 OS=Bos taurus GN=UQCRB PE=1 SV=3 PF02271 Ubiquinol-cytochrome C reductase complex 14kD subunit GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750 mitochondrial respiratory chain complex III KOG3440 Ubiquinol cytochrome c reductase, subunit QCR7 Cluster-8309.18648 BF_2 53.59 1.46 1825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18649 BF_2 4.00 0.46 654 442565876 AGC56218.1 972 8.3e-103 heat shock protein 70 [Dermatophagoides farinae] 356578609 HQ693484.1 416 0 Alternaria alternata strain CBS 109803 heat shock protein 70 (hsp70) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q96W30 1029 8.4e-111 Heat shock 70 kDa protein 2 OS=Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) GN=HSP70-2 PE=2 SV=2 PF01968//PF06723 Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0016787 hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.18650 BF_2 33.00 1.39 1282 831771570 XP_012753341.1 1227 4.4e-132 hypothetical protein SAMD00019534_067750 [Acytostelium subglobosum LB1]>gi|355336752|gb|AER57861.1| heat shock cognate protein Hsc70-2 [Acytostelium subglobosum]>gi|735853973|dbj|GAM23600.1| hypothetical protein SAMD00019534_067750 [Acytostelium subglobosum LB1] 590629656 XM_007026990.1 685 0 Theobroma cacao Heat shock cognate protein 70-1 isoform 1 (TCM_021961) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P27322 1530 1.3e-168 Heat shock cognate 70 kDa protein 2 OS=Solanum lycopersicum GN=HSC-2 PE=2 SV=1 PF13499//PF02782 EF-hand domain pair//FGGY family of carbohydrate kinases, C-terminal domain GO:0006950//GO:0005975 response to stress//carbohydrate metabolic process GO:0005509//GO:0005524//GO:0016773 calcium ion binding//ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.18654 BF_2 70.00 9.57 593 332375064 AEE62673.1 327 4.6e-28 unknown [Dendroctonus ponderosae]>gi|478249845|gb|ENN70352.1| hypothetical protein YQE_12860, partial [Dendroctonus ponderosae]>gi|546671451|gb|ERL83760.1| hypothetical protein D910_00980 [Dendroctonus ponderosae]>gi|546672508|gb|ERL84338.1| hypothetical protein D910_01758 [Dendroctonus ponderosae]>gi|546686966|gb|ERL95929.1| hypothetical protein D910_00611 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 229 4.4e-18 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089//PF06003 Trypsin//Survival motor neuron protein (SMN) GO:0006508//GO:0006397 proteolysis//mRNA processing GO:0004252//GO:0003723 serine-type endopeptidase activity//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.18659 BF_2 82.49 3.33 1324 642919913 XP_008192122.1 654 1.3e-65 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18660 BF_2 21.34 0.72 1534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18661 BF_2 173.00 6.86 1342 642933995 XP_008197596.1 880 7.9e-92 PREDICTED: uncharacterized protein LOC100142086 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06423//PF12822 GWT1//Protein of unknown function (DUF3816) GO:0006506//GO:0006810 GPI anchor biosynthetic process//transport GO:0016746//GO:0005215 transferase activity, transferring acyl groups//transporter activity GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.18664 BF_2 10.00 1.28 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18669 BF_2 384.31 4.67 3728 642920032 XP_008192175.1 1056 8.6e-112 PREDICTED: uncharacterized protein LOC103312676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A5V7 533 1.6e-52 Transmembrane protein 41B OS=Danio rerio GN=tmem41b PE=2 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG3140 Predicted membrane protein Cluster-8309.18675 BF_2 43.00 2.16 1121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18677 BF_2 9.00 0.97 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18678 BF_2 4.00 0.52 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18681 BF_2 178.00 7.19 1323 828177640 AKK25143.1 279 3.8e-22 odorant binding protein 19 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27017 156 2.9e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395//PF00584//PF09061//PF07813 PBP/GOBP family//SecE/Sec61-gamma subunits of protein translocation complex//Stirrup//LTXXQ motif family protein GO:0006605//GO:0006886 protein targeting//intracellular protein transport GO:0016788//GO:0005549 hydrolase activity, acting on ester bonds//odorant binding GO:0016020//GO:0042597 membrane//periplasmic space -- -- Cluster-8309.18686 BF_2 8.00 0.74 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18687 BF_2 111.22 4.18 1400 642923865 XP_966645.3 1281 2.6e-138 PREDICTED: TBC1 domain family member 20 isoform X2 [Tribolium castaneum] 462282558 APGK01057257.1 55 1.66729e-17 Dendroctonus ponderosae Seq01057267, whole genome shotgun sequence -- -- -- -- Q9D9I4 693 1.6e-71 TBC1 domain family member 20 OS=Mus musculus GN=Tbc1d20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2595 Predicted GTPase activator protein Cluster-8309.18688 BF_2 6.00 1.40 466 795008009 XP_011864941.1 234 2.2e-17 PREDICTED: uncharacterized protein LOC105560403, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18689 BF_2 31.00 0.81 1891 795008352 XP_011883559.1 291 2.2e-23 PREDICTED: uncharacterized protein LOC105570729 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.1869 BF_2 3.00 0.47 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18690 BF_2 11.00 0.36 1577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18693 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08728 CRT10 GO:0006357 regulation of transcription from RNA polymerase II promoter -- -- -- -- -- -- Cluster-8309.18701 BF_2 53.10 0.72 3368 546679820 ERL90212.1 1294 2.0e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BQA5 823 3.3e-86 Histone H4 transcription factor OS=Homo sapiens GN=HINFP PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.18702 BF_2 9.00 1.44 549 281212335 EFA86495.1 183 2.1e-11 putative polyketide synthase [Polysphondylium pallidum PN500] 9367768 AJ278456.1 276 8.82267e-141 Juglans nigra mRNA for chalcone synthase (CHS gene) -- -- -- -- Q9FUB7 707 1.5e-73 Chalcone synthase OS=Hypericum androsaemum PE=1 SV=1 PF08541//PF05965 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//F/Y rich C-terminus GO:0008610 lipid biosynthetic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005634 nucleus -- -- Cluster-8309.18703 BF_2 25.72 0.75 1727 270010175 EFA06623.1 1474 1.3e-160 hypothetical protein TcasGA2_TC009541 [Tribolium castaneum] -- -- -- -- -- K10481 BTBD9 BTB/POZ domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10481 A4IFG2 807 1.2e-84 BTB/POZ domain-containing protein 9 OS=Bos taurus GN=BTBD9 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.18704 BF_2 19.29 2.13 666 91084843 XP_966905.1 344 5.6e-30 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 230 3.8e-18 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18705 BF_2 36.91 1.60 1254 642922630 XP_970967.2 699 7.2e-71 PREDICTED: probable RNA methyltransferase CG11342 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VZD2 524 5.8e-52 Probable RNA methyltransferase CG11342 OS=Drosophila melanogaster GN=CG11342 PE=3 SV=1 PF02390//PF06859//PF08241 Putative methyltransferase//Bicoid-interacting protein 3 (Bin3)//Methyltransferase domain GO:0008152//GO:0009451//GO:0006400//GO:0008033 metabolic process//RNA modification//tRNA modification//tRNA processing GO:0008168//GO:0008176 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.18708 BF_2 138.71 1.65 3807 642925645 XP_008194653.1 4733 0.0e+00 PREDICTED: potassium voltage-gated channel subfamily H member 6-like isoform X1 [Tribolium castaneum] 642925644 XM_008196431.1 608 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel subfamily H member 6-like (LOC662676), transcript variant X1, mRNA K04910 KCNH7 potassium voltage-gated channel Eag-related subfamily H member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04910 Q9ER47 1874 5.1e-208 Potassium voltage-gated channel subfamily H member 7 OS=Mus musculus GN=Kcnh7 PE=2 SV=2 PF00989//PF08447//PF00520 PAS fold//PAS fold//Ion transport protein GO:0006355//GO:0055085//GO:0006811 regulation of transcription, DNA-templated//transmembrane transport//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-8309.18711 BF_2 6.91 0.76 669 73921480 AAZ94270.1 285 3.9e-23 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 238 4.5e-19 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067//PF02979 Cytochrome P450//Nitrile hydratase, alpha chain GO:0055114//GO:0006807 oxidation-reduction process//nitrogen compound metabolic process GO:0003824//GO:0016705//GO:0046914//GO:0016491//GO:0005488//GO:0005506//GO:0020037 catalytic activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//transition metal ion binding//oxidoreductase activity//binding//iron ion binding//heme binding -- -- -- -- Cluster-8309.18713 BF_2 17.58 0.40 2144 91082807 XP_968134.1 902 3.6e-94 PREDICTED: general transcription factor IIF subunit 2 [Tribolium castaneum]>gi|270007102|gb|EFA03550.1| hypothetical protein TcasGA2_TC013555 [Tribolium castaneum] 755881816 XM_005185870.2 95 1.49651e-39 PREDICTED: Musca domestica general transcription factor IIF subunit 2 (LOC101901202), mRNA K03139 TFIIF2, GTF2F2, TFG2 transcription initiation factor TFIIF subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03139 P41900 683 3.6e-70 General transcription factor IIF subunit 2 OS=Drosophila melanogaster GN=TfIIFbeta PE=2 SV=2 PF02270 Transcription initiation factor IIF, beta subunit GO:0006367//GO:0006366 transcription initiation from RNA polymerase II promoter//transcription from RNA polymerase II promoter GO:0003824//GO:0005524 catalytic activity//ATP binding GO:0005674 transcription factor TFIIF complex KOG2905 Transcription initiation factor IIF, small subunit (RAP30) Cluster-8309.18714 BF_2 60.00 2.40 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01736 Polyomavirus agnoprotein -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.18715 BF_2 11.00 0.64 1001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18716 BF_2 38.80 1.24 1593 548544410 XP_005753889.1 472 1.9e-44 PREDICTED: zinc finger protein 84-like [Pundamilia nyererei] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 434 2.0e-41 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF07776//PF13912//PF04810//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.18718 BF_2 7.00 0.45 942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18721 BF_2 64.86 2.42 1408 91076100 XP_968498.1 1228 3.7e-132 PREDICTED: neurotrimin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O97394 137 4.9e-07 Protein sidekick OS=Drosophila melanogaster GN=sdk PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18723 BF_2 24.98 0.86 1501 642911636 XP_008200681.1 1225 8.8e-132 PREDICTED: kin of IRRE-like protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18732 BF_2 231.94 26.81 649 741829513 AJA91072.1 568 5.8e-56 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 442 9.7e-43 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.18733 BF_2 86.72 2.53 1721 741829513 AJA91072.1 830 6.4e-86 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 585 6.7e-59 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0051249//GO:0006955//GO:0055114 regulation of lymphocyte activation//immune response//oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.18734 BF_2 190.18 1.33 6252 189235646 XP_968349.2 2120 6.0e-235 PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Tribolium castaneum] 642917490 XM_963256.3 673 0 PREDICTED: Tribolium castaneum peripheral plasma membrane protein CASK (LOC656749), transcript variant X4, mRNA K06103 CASK calcium/calmodulin-dependent serine protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06103 Q24210 1852 3.0e-205 Peripheral plasma membrane protein CASK OS=Drosophila melanogaster GN=CASK PE=1 SV=4 PF13180//PF14604//PF00595//PF00018//PF01003 PDZ domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//Flavivirus capsid protein C -- -- GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0019028 viral capsid KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.18735 BF_2 82.25 1.58 2461 91088003 XP_973796.1 525 2.1e-50 PREDICTED: putative RNA-binding protein Luc7-like 2 [Tribolium castaneum]>gi|270011896|gb|EFA08344.1| hypothetical protein TcasGA2_TC005987 [Tribolium castaneum] -- -- -- -- -- K13212 LUC7L2 RNA-binding protein Luc7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13212 Q9Y383 397 6.1e-37 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 PF07851//PF03194//PF01442 TMPIT-like protein//LUC7 N_terminus//Apolipoprotein A1/A4/E domain GO:0006869//GO:0042157//GO:0006376 lipid transport//lipoprotein metabolic process//mRNA splice site selection GO:0008289//GO:0003729 lipid binding//mRNA binding GO:0005685//GO:0016021//GO:0005576 U1 snRNP//integral component of membrane//extracellular region KOG0796 Spliceosome subunit Cluster-8309.18736 BF_2 12.00 2.61 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18739 BF_2 25.72 0.39 3041 478256841 ENN77016.1 1079 1.5e-114 hypothetical protein YQE_06510, partial [Dendroctonus ponderosae]>gi|546673799|gb|ERL85343.1| hypothetical protein D910_02763 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V785 768 7.2e-80 SH3 domain-binding protein 5 homolog OS=Drosophila melanogaster GN=pcs PE=1 SV=4 PF01484//PF07851 Nematode cuticle collagen N-terminal domain//TMPIT-like protein -- -- GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.18740 BF_2 47.77 1.05 2186 642911317 XP_008199368.1 211 4.8e-14 PREDICTED: uncharacterized protein LOC103314647 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09508 Lacto-N-biose phosphorylase -- -- GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.18741 BF_2 109.58 1.81 2816 478250852 ENN71341.1 1034 2.3e-109 hypothetical protein YQE_11956, partial [Dendroctonus ponderosae]>gi|546678340|gb|ERL88982.1| hypothetical protein D910_06360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VPK7 587 6.5e-59 Putative tRNA pseudouridine synthase Pus10 OS=Drosophila melanogaster GN=Pus10 PE=2 SV=2 PF02058//PF01416 Guanylin precursor//tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0009982//GO:0003723//GO:0030250 pseudouridine synthase activity//RNA binding//guanylate cyclase activator activity GO:0005576 extracellular region KOG2364 Predicted pseudouridylate synthase Cluster-8309.18742 BF_2 2.00 0.39 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18746 BF_2 86.95 0.75 5138 642917385 XP_008199669.1 1119 5.9e-119 PREDICTED: uncharacterized protein LOC658463 [Tribolium castaneum]>gi|270003013|gb|EEZ99460.1| hypothetical protein TcasGA2_TC000026 [Tribolium castaneum] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 8.1e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF03153//PF05271//PF05019 Transcription factor IIA, alpha/beta subunit//Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006367//GO:0019089//GO:0006744 transcription initiation from RNA polymerase II promoter//transmission of virus//ubiquinone biosynthetic process -- -- GO:0005672 transcription factor TFIIA complex KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.18747 BF_2 63.11 2.69 1268 748995284 AJE75664.1 1350 2.4e-146 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 822 1.6e-86 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.18748 BF_2 1017.37 30.78 1670 748995284 AJE75664.1 1898 8.9e-210 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1090 1.8e-117 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232//PF00331 Glycosyl hydrolase family 1//Glycosyl hydrolase family 10 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.18750 BF_2 17.73 0.44 1975 332373444 AEE61863.1 817 2.4e-84 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 690 5.2e-71 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF13241//PF03435//PF01266//PF01134//PF02558//PF00056//PF00070//PF00899//PF03721//PF01494//PF02737//PF07992//PF01399//PF02254 Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ThiF family//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//FAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//PCI domain//TrkA-N domain GO:0006813//GO:0019354//GO:0018874//GO:0006633//GO:0006552//GO:0006631//GO:0015940//GO:0006550//GO:0006574//GO:0055114//GO:0006779//GO:0008033//GO:0006554//GO:0006568 potassium ion transport//siroheme biosynthetic process//benzoate metabolic process//fatty acid biosynthetic process//leucine catabolic process//fatty acid metabolic process//pantothenate biosynthetic process//isoleucine catabolic process//valine catabolic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//tRNA processing//lysine catabolic process//tryptophan metabolic process GO:0051287//GO:0005515//GO:0016491//GO:0043115//GO:0008641//GO:0050660//GO:0008677//GO:0016616//GO:0071949//GO:0003857 NAD binding//protein binding//oxidoreductase activity//precorrin-2 dehydrogenase activity//small protein activating enzyme activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FAD binding//3-hydroxyacyl-CoA dehydrogenase activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.18751 BF_2 182.86 6.46 1472 91090662 XP_974317.1 1378 1.6e-149 PREDICTED: ubiquitin-like domain-containing CTD phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K17618 UBLCP1 ubiquitin-like domain-containing CTD phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17618 Q6DI37 1028 2.5e-110 Ubiquitin-like domain-containing CTD phosphatase 1 OS=Danio rerio GN=ublcp1 PE=2 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG1872 Ubiquitin-specific protease Cluster-8309.18752 BF_2 58.70 1.53 1894 332373444 AEE61863.1 858 4.0e-89 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 724 5.6e-75 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF01134//PF02558//PF00070//PF00056//PF03721//PF00899//PF13241//PF03435//PF01266//PF02254//PF01494//PF07992//PF02737//PF01399 Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//Pyridine nucleotide-disulphide oxidoreductase//lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//TrkA-N domain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//PCI domain GO:0019354//GO:0006633//GO:0018874//GO:0006813//GO:0006631//GO:0006552//GO:0015940//GO:0006574//GO:0006550//GO:0006568//GO:0008033//GO:0006779//GO:0006554//GO:0055114 siroheme biosynthetic process//fatty acid biosynthetic process//benzoate metabolic process//potassium ion transport//fatty acid metabolic process//leucine catabolic process//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//tryptophan metabolic process//tRNA processing//porphyrin-containing compound biosynthetic process//lysine catabolic process//oxidation-reduction process GO:0043115//GO:0016491//GO:0005515//GO:0051287//GO:0050660//GO:0008677//GO:0008641//GO:0071949//GO:0016616//GO:0003857 precorrin-2 dehydrogenase activity//oxidoreductase activity//protein binding//NAD binding//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.18756 BF_2 4.00 0.47 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18759 BF_2 9.61 0.47 1147 270015247 EFA11695.1 385 1.7e-34 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404 AsnC-type helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.18764 BF_2 11.00 2.63 462 270016741 EFA13187.1 194 9.6e-13 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SVZ6 134 3.6e-07 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.18769 BF_2 48.61 0.90 2534 189234109 XP_001813540.1 984 1.3e-103 PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|642912138|ref|XP_008200823.1| PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|270002521|gb|EEZ98968.1| hypothetical protein TcasGA2_TC004823 [Tribolium castaneum] 665818633 XM_008559932.1 56 8.48689e-18 PREDICTED: Microplitis demolitor methyltransferase-like protein 6 (LOC103578761), transcript variant X2, mRNA K00599 METTL6 methyltransferase-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00599 Q8BVH9 764 1.7e-79 Methyltransferase-like protein 6 OS=Mus musculus GN=Mettl6 PE=2 SV=2 PF00106//PF01209//PF01234//PF08241//PF02390//PF05724//PF05175//PF05958 short chain dehydrogenase//ubiE/COQ5 methyltransferase family//NNMT/PNMT/TEMT family//Methyltransferase domain//Putative methyltransferase//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//tRNA (Uracil-5-)-methyltransferase GO:0009451//GO:0008033//GO:0006396//GO:0006400//GO:0032259//GO:0008152 RNA modification//tRNA processing//RNA processing//tRNA modification//methylation//metabolic process GO:0008176//GO:0008168//GO:0008757//GO:0016491//GO:0008173 tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//oxidoreductase activity//RNA methyltransferase activity -- -- KOG2361 Predicted methyltransferase Cluster-8309.18770 BF_2 29.52 3.90 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18771 BF_2 111.43 1.88 2768 189234109 XP_001813540.1 984 1.4e-103 PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|642912138|ref|XP_008200823.1| PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|270002521|gb|EEZ98968.1| hypothetical protein TcasGA2_TC004823 [Tribolium castaneum] 665818633 XM_008559932.1 56 9.27528e-18 PREDICTED: Microplitis demolitor methyltransferase-like protein 6 (LOC103578761), transcript variant X2, mRNA K00599 METTL6 methyltransferase-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00599 Q8BVH9 764 1.9e-79 Methyltransferase-like protein 6 OS=Mus musculus GN=Mettl6 PE=2 SV=2 PF01234//PF05724//PF05175//PF02390//PF08241//PF05958//PF00106//PF01209 NNMT/PNMT/TEMT family//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain//tRNA (Uracil-5-)-methyltransferase//short chain dehydrogenase//ubiE/COQ5 methyltransferase family GO:0009451//GO:0006396//GO:0008033//GO:0032259//GO:0006400//GO:0008152 RNA modification//RNA processing//tRNA processing//methylation//tRNA modification//metabolic process GO:0008176//GO:0008168//GO:0008757//GO:0016491//GO:0008173 tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//oxidoreductase activity//RNA methyltransferase activity -- -- KOG2361 Predicted methyltransferase Cluster-8309.18772 BF_2 23.53 0.62 1887 189234109 XP_001813540.1 664 1.2e-66 PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|642912138|ref|XP_008200823.1| PREDICTED: methyltransferase-like protein 6 [Tribolium castaneum]>gi|270002521|gb|EEZ98968.1| hypothetical protein TcasGA2_TC004823 [Tribolium castaneum] 665818633 XM_008559932.1 56 6.28961e-18 PREDICTED: Microplitis demolitor methyltransferase-like protein 6 (LOC103578761), transcript variant X2, mRNA K00599 METTL6 methyltransferase-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00599 Q5RDV8 534 6.1e-53 Methyltransferase-like protein 6 OS=Pongo abelii GN=METTL6 PE=2 SV=1 PF01234//PF00106//PF08241//PF05724//PF05175 NNMT/PNMT/TEMT family//short chain dehydrogenase//Methyltransferase domain//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain GO:0032259//GO:0008152 methylation//metabolic process GO:0016491//GO:0008168//GO:0008757 oxidoreductase activity//methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity -- -- KOG2361 Predicted methyltransferase Cluster-8309.18773 BF_2 21.44 1.93 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18775 BF_2 2.43 0.41 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18776 BF_2 106.11 0.67 6925 642938901 XP_008195529.1 3175 0.0e+00 PREDICTED: FCH and double SH3 domains protein 2 [Tribolium castaneum]>gi|270016165|gb|EFA12613.1| hypothetical protein TcasGA2_TC006854 [Tribolium castaneum] 158286862 XM_308970.4 176 4.58322e-84 Anopheles gambiae str. PEST AGAP006774-PA (AgaP_AGAP006774) mRNA, complete cds -- -- -- -- O94868 971 4.7e-103 F-BAR and double SH3 domains protein 2 OS=Homo sapiens GN=FCHSD2 PE=1 SV=3 PF01997//PF12601//PF14604//PF00018 Translin family//Rubivirus non-structural protein//Variant SH3 domain//SH3 domain GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0043565//GO:0017111//GO:0016817//GO:0004197//GO:0005515 RNA-directed RNA polymerase activity//sequence-specific DNA binding//nucleoside-triphosphatase activity//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.18781 BF_2 18.00 1.93 678 91083843 XP_973852.1 409 1.6e-37 PREDICTED: larval cuticle protein LCP-30 [Tribolium castaneum]>gi|270006765|gb|EFA03213.1| hypothetical protein TcasGA2_TC013133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P85197 231 3.0e-18 Cuticle protein 3 OS=Lonomia obliqua PE=1 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.18783 BF_2 202.00 13.35 920 91083333 XP_974927.1 653 1.1e-65 PREDICTED: probable Golgi SNAP receptor complex member 2 [Tribolium castaneum]>gi|270006922|gb|EFA03370.1| hypothetical protein TcasGA2_TC013356 [Tribolium castaneum] -- -- -- -- -- K08496 GOSR2, BOS1 golgi SNAP receptor complex member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08496 Q9VRL2 382 1.2e-35 Probable Golgi SNAP receptor complex member 2 OS=Drosophila melanogaster GN=membrin PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3251 Golgi SNAP receptor complex member Cluster-8309.18786 BF_2 32.20 2.08 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18789 BF_2 18.00 1.02 1027 91077070 XP_969313.1 198 7.3e-13 PREDICTED: metal transporter CNNM4 [Tribolium castaneum]>gi|270002030|gb|EEZ98477.1| hypothetical protein TcasGA2_TC000970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18790 BF_2 129.00 8.75 904 332377007 AEE63643.1 577 7.3e-57 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 382 1.2e-35 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0007423//GO:0006446//GO:0006413 sensory organ development//regulation of translational initiation//translational initiation GO:0005212//GO:0003743 structural constituent of eye lens//translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.18791 BF_2 7.00 2.86 388 546675072 ERL86327.1 188 4.0e-12 hypothetical protein D910_03735 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VMS7 126 2.5e-06 Probable cytochrome P450 4ac3 OS=Drosophila melanogaster GN=Cyp4ac3 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.18794 BF_2 992.88 26.12 1877 91090334 XP_966832.1 1009 1.2e-106 PREDICTED: uncharacterized protein LOC655224 [Tribolium castaneum]>gi|642934945|ref|XP_008195892.1| PREDICTED: uncharacterized protein LOC655224 [Tribolium castaneum]>gi|270013818|gb|EFA10266.1| hypothetical protein TcasGA2_TC012466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18798 BF_2 94.08 2.54 1839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18799 BF_2 89.97 4.84 1065 642920715 XP_008192533.1 936 2.0e-98 PREDICTED: TATA-box-binding protein isoform X1 [Tribolium castaneum]>gi|270005208|gb|EFA01656.1| hypothetical protein TcasGA2_TC007228 [Tribolium castaneum] -- -- -- -- -- K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 P53361 651 9.2e-67 TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.18800 BF_2 38.52 0.47 3688 189234638 XP_975412.2 1908 1.4e-210 PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913950|ref|XP_008201227.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|642913953|ref|XP_008201229.1| PREDICTED: suppressor of fused homolog [Tribolium castaneum]>gi|270001630|gb|EEZ98077.1| hypothetical protein TcasGA2_TC000484 [Tribolium castaneum] -- -- -- -- -- K06229 SUFU suppressor of fused http://www.genome.jp/dbget-bin/www_bget?ko:K06229 Q9Z0P7 971 2.5e-103 Suppressor of fused homolog OS=Mus musculus GN=Sufu PE=1 SV=1 PF12470 Suppressor of Fused Gli/Ci N terminal binding domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.18801 BF_2 49.00 1.60 1567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05424 Duffy binding domain GO:0009405//GO:0007165 pathogenesis//signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.18807 BF_2 21.00 0.51 1994 861633222 KMQ90883.1 846 1.0e-87 hypothetical protein RF55_9309 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18808 BF_2 4.00 0.48 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18809 BF_2 231.00 4.13 2629 189241943 XP_971607.2 1924 1.4e-212 PREDICTED: uncharacterized aarF domain-containing protein kinase 1 [Tribolium castaneum]>gi|270015338|gb|EFA11786.1| hypothetical protein TcasGA2_TC008565 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q5ZMT7 1163 9.8e-126 Uncharacterized aarF domain-containing protein kinase 1 OS=Gallus gallus GN=ADCK1 PE=2 SV=1 PF09788//PF00069 Transmembrane protein 55A//Protein kinase domain GO:0006468//GO:0046856 protein phosphorylation//phosphatidylinositol dephosphorylation GO:0034597//GO:0004672//GO:0005524//GO:0016772 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//protein kinase activity//ATP binding//transferase activity, transferring phosphorus-containing groups -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.18811 BF_2 76.97 1.95 1935 820805520 AKG92751.1 846 1.0e-87 steroid receptor coactivator [Leptinotarsa decemlineata] 820805519 KP147914.1 185 1.25612e-89 Leptinotarsa decemlineata steroid receptor coactivator mRNA, complete cds K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 -- -- -- -- PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.18817 BF_2 19.40 0.49 1950 270007899 EFA04347.1 387 1.7e-34 hypothetical protein TcasGA2_TC014643 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D6REC4 130 4.4e-06 Cilia- and flagella-associated protein 99 OS=Homo sapiens GN=CFAP99 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18818 BF_2 272.00 10.35 1386 642920988 XP_974589.2 1430 1.4e-155 PREDICTED: ATPase ASNA1 homolog [Tribolium castaneum] 641655703 XM_001943502.3 104 9.51886e-45 PREDICTED: Acyrthosiphon pisum ATPase ASNA1 homolog (LOC100162894), mRNA K01551 arsA, ASNA1 arsenite-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01551 Q16MG9 1279 1.8e-139 ATPase ASNA1 homolog OS=Aedes aegypti GN=AAEL011136 PE=3 SV=1 PF02562//PF06414//PF00448 PhoH-like protein//Zeta toxin//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0005524//GO:0016301 GTP binding//ATP binding//kinase activity -- -- KOG2825 Putative arsenite-translocating ATPase Cluster-8309.18821 BF_2 528.32 14.84 1776 642936319 XP_008198394.1 672 1.4e-67 PREDICTED: equilibrative nucleoside transporter 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZD2 274 8.0e-23 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF07690//PF01733 Major Facilitator Superfamily//Nucleoside transporter GO:0055085//GO:0015858//GO:0006810 transmembrane transport//nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.18826 BF_2 42.81 0.98 2118 642930369 XP_008196368.1 2144 3.4e-238 PREDICTED: dymeclin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q293C2 1308 1.2e-142 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2225 Proteins containing regions of low-complexity Cluster-8309.18828 BF_2 625.00 44.10 880 749779245 XP_011144213.1 390 3.4e-35 PREDICTED: trypsin-1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- O97399 359 5.5e-33 Trypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.18832 BF_2 61.15 0.34 7707 91086723 XP_970869.1 796 2.5e-81 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 2.04106e-08 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 560 2.4e-55 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535//PF08022//PF04893 ZIP Zinc transporter//FAD-binding domain//Yip1 domain GO:0055085//GO:0030001//GO:0055114 transmembrane transport//metal ion transport//oxidation-reduction process GO:0046873//GO:0016491 metal ion transmembrane transporter activity//oxidoreductase activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.18833 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18834 BF_2 84.00 0.89 4251 91080503 XP_971456.1 546 1.3e-52 PREDICTED: fasciclin-2 [Tribolium castaneum]>gi|642919288|ref|XP_008191811.1| PREDICTED: fasciclin-2 [Tribolium castaneum]>gi|642919290|ref|XP_008191812.1| PREDICTED: fasciclin-2 [Tribolium castaneum]>gi|270005773|gb|EFA02221.1| hypothetical protein TcasGA2_TC007882 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35136 179 2.0e-11 Neural cell adhesion molecule 2 OS=Mus musculus GN=Ncam2 PE=2 SV=1 PF02300//PF00041//PF13895 Fumarate reductase subunit C//Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.18835 BF_2 56.00 1.27 2139 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18836 BF_2 15.00 7.93 363 -- -- -- -- -- 115474642 NM_001067453.1 363 0 Oryza sativa Japonica Group Os08g0129800 (Os08g0129800) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18840 BF_2 8.00 1.00 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18842 BF_2 209.45 1.33 6888 642918714 XP_008191551.1 3440 0.0e+00 PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|642918716|ref|XP_008191552.1| PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|270005665|gb|EFA02113.1| hypothetical protein TcasGA2_TC007759 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 Q13393 1678 4.9e-185 Phospholipase D1 OS=Homo sapiens GN=PLD1 PE=1 SV=1 PF00614//PF00787//PF02399 Phospholipase D Active site motif//PX domain//Origin of replication binding protein GO:0006260//GO:0007154//GO:0008152 DNA replication//cell communication//metabolic process GO:0003688//GO:0003824//GO:0005524//GO:0035091 DNA replication origin binding//catalytic activity//ATP binding//phosphatidylinositol binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.18853 BF_2 4.92 0.43 763 478256534 ENN76718.1 311 4.3e-26 hypothetical protein YQE_06783, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NZL3 220 6.3e-17 Zinc finger protein 224 OS=Homo sapiens GN=ZNF224 PE=1 SV=3 PF00096//PF13465//PF00450//PF00628//PF02892//PF16622//PF01428 Zinc finger, C2H2 type//Zinc-finger double domain//Serine carboxypeptidase//PHD-finger//BED zinc finger//zinc-finger C2H2-type//AN1-like Zinc finger GO:0006508 proteolysis GO:0003677//GO:0008270//GO:0005515//GO:0004185//GO:0046872 DNA binding//zinc ion binding//protein binding//serine-type carboxypeptidase activity//metal ion binding -- -- -- -- Cluster-8309.18854 BF_2 56.28 1.30 2101 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18855 BF_2 255.82 3.17 3666 478261352 ENN80758.1 618 5.2e-61 hypothetical protein YQE_02823, partial [Dendroctonus ponderosae]>gi|546684265|gb|ERL93970.1| hypothetical protein D910_11255 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00715//PF05493 Interleukin 2//ATP synthase subunit H GO:0015991//GO:0008283//GO:0007165//GO:0040007//GO:0015992//GO:0006955 ATP hydrolysis coupled proton transport//cell proliferation//signal transduction//growth//proton transport//immune response GO:0008083//GO:0005134//GO:0015078 growth factor activity//interleukin-2 receptor binding//hydrogen ion transmembrane transporter activity GO:0033179//GO:0005893//GO:0005576 proton-transporting V-type ATPase, V0 domain//interleukin-2 receptor complex//extracellular region -- -- Cluster-8309.18860 BF_2 25.00 2.06 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00272//PF15180 Cecropin family//Neuropeptides B and W GO:0007165 signal transduction GO:0001664 G-protein coupled receptor binding GO:0005576 extracellular region -- -- Cluster-8309.18861 BF_2 92.68 1.30 3260 91087279 XP_975547.1 1604 2.1e-175 PREDICTED: DNA repair protein complementing XP-C cells homolog [Tribolium castaneum]>gi|270009546|gb|EFA05994.1| hypothetical protein TcasGA2_TC008820 [Tribolium castaneum] -- -- -- -- -- K10838 XPC xeroderma pigmentosum group C-complementing protein http://www.genome.jp/dbget-bin/www_bget?ko:K10838 Q24595 1174 6.4e-127 DNA repair protein complementing XP-C cells homolog OS=Drosophila melanogaster GN=mus210 PE=1 SV=2 PF10404//PF10403//PF10405 Rad4 beta-hairpin domain 2//Rad4 beta-hairpin domain 1//Rad4 beta-hairpin domain 3 -- -- GO:0003677 DNA binding -- -- KOG2179 Nucleotide excision repair complex XPC-HR23B, subunit XPC/DPB11 Cluster-8309.18863 BF_2 4.00 1.08 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18864 BF_2 6.00 0.61 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18866 BF_2 3.00 0.33 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18869 BF_2 196.70 17.11 768 91079352 XP_969834.1 637 6.8e-64 PREDICTED: mediator of RNA polymerase II transcription subunit 10 [Tribolium castaneum]>gi|270004361|gb|EFA00809.1| hypothetical protein TcasGA2_TC003696 [Tribolium castaneum] -- -- -- -- -- K15151 MED10, NUT2 mediator of RNA polymerase II transcription subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K15151 Q16G71 536 1.4e-53 Mediator of RNA polymerase II transcription subunit 10 OS=Aedes aegypti GN=MED10 PE=3 SV=1 PF09748//PF05531 Transcription factor subunit Med10 of Mediator complex//Nucleopolyhedrovirus P10 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0019028 mediator complex//viral capsid KOG3046 Transcription factor, subunit of SRB subcomplex of RNA polymerase II Cluster-8309.18871 BF_2 39.53 0.85 2242 307186601 EFN72115.1 424 1.0e-38 hypothetical protein EAG_00326, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02160 Cauliflower mosaic virus peptidase (A3) GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.18872 BF_2 38.11 0.36 4656 91082885 XP_971739.1 364 1.9e-31 PREDICTED: leucine-rich repeat extensin-like protein 3 [Tribolium castaneum]>gi|270007607|gb|EFA04055.1| hypothetical protein TcasGA2_TC014287 [Tribolium castaneum] 642923275 XM_966646.2 63 2.0147e-21 PREDICTED: Tribolium castaneum leucine-rich repeat extensin-like protein 3 (LOC660415), mRNA -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.18873 BF_2 13.50 0.37 1794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18875 BF_2 126.00 13.22 686 -- -- -- -- -- 284431761 FJ940200.1 661 0 Oryza sativa Japonica Group clone KCS045C09 prolamin mRNA, complete cds -- -- -- -- P20698 307 4.6e-27 Prolamin PPROL 17D OS=Oryza sativa subsp. japonica GN=Os12g0269200 PE=2 SV=2 PF00255 Glutathione peroxidase GO:0006804//GO:0055114//GO:0006979//GO:0006749 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress//glutathione metabolic process GO:0004602 glutathione peroxidase activity -- -- -- -- Cluster-8309.18882 BF_2 2.00 0.54 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18883 BF_2 42.31 0.87 2321 642937299 XP_008198776.1 838 1.0e-86 PREDICTED: DNA excision repair protein ERCC-1 [Tribolium castaneum] -- -- -- -- -- K10849 ERCC1 DNA excision repair protein ERCC-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10849 P07992 621 6.1e-63 DNA excision repair protein ERCC-1 OS=Homo sapiens GN=ERCC1 PE=1 SV=1 PF07690//PF10391//PF01296//PF01367//PF00633 Major Facilitator Superfamily//Fingers domain of DNA polymerase lambda//Galanin//5'-3' exonuclease, C-terminal SAM fold//Helix-hairpin-helix motif GO:0007165//GO:0055085 signal transduction//transmembrane transport GO:0003824//GO:0003677//GO:0005179//GO:0034061 catalytic activity//DNA binding//hormone activity//DNA polymerase activity GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG2841 Structure-specific endonuclease ERCC1-XPF, ERCC1 component Cluster-8309.18884 BF_2 9.05 0.33 1441 861588173 KMQ82585.1 435 3.4e-40 transposase-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13683//PF02262 Integrase core domain//CBL proto-oncogene N-terminal domain 1 GO:0007165//GO:0015074//GO:0007166 signal transduction//DNA integration//cell surface receptor signaling pathway GO:0004871 signal transducer activity GO:0005634 nucleus -- -- Cluster-8309.18885 BF_2 10.78 0.37 1500 861599125 KMQ83546.1 293 1.0e-23 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18887 BF_2 16.17 0.54 1537 861605932 KMQ84424.1 396 1.2e-35 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.18892 BF_2 24.29 0.56 2096 659099915 AID60336.1 596 1.1e-58 trypsin-2 [Nilaparvata lugens]>gi|659100019|gb|AID60340.1| trypsin-6 [Nilaparvata lugens] 584066431 XM_006753576.1 36 9.18331e-07 PREDICTED: Myotis davidii kallikrein-related peptidase 11 (KLK11), transcript variant X2, mRNA K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 Q8MQS8 416 3.2e-39 Venom serine protease 34 OS=Apis mellifera PE=2 SV=1 PF00089//PF16622 Trypsin//zinc-finger C2H2-type GO:0006508 proteolysis GO:0046872//GO:0004252 metal ion binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.18895 BF_2 4.00 0.75 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18898 BF_2 23.00 1.26 1052 641666417 XP_008183728.1 316 1.6e-26 PREDICTED: transcription factor Adf-1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P05552 133 1.1e-06 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF00485//PF01097//PF02944 Phosphoribulokinase / Uridine kinase family//Arthropod defensin//BESS motif GO:0008152//GO:0006952 metabolic process//defense response GO:0003677//GO:0016301//GO:0005524 DNA binding//kinase activity//ATP binding -- -- -- -- Cluster-8309.18902 BF_2 33.00 5.31 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18904 BF_2 131.00 8.11 963 642935480 XP_008198027.1 373 3.5e-33 PREDICTED: filament-like plant protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03039//PF00715 Interleukin-12 alpha subunit//Interleukin 2 GO:0006955//GO:0040007//GO:0007165//GO:0008283 immune response//growth//signal transduction//cell proliferation GO:0005134//GO:0005143//GO:0008083 interleukin-2 receptor binding//interleukin-12 receptor binding//growth factor activity GO:0005576//GO:0005893//GO:0042022 extracellular region//interleukin-2 receptor complex//interleukin-12 receptor complex -- -- Cluster-8309.18908 BF_2 4.53 0.37 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18914 BF_2 49.00 12.48 451 307210441 EFN86995.1 173 2.5e-10 hypothetical protein EAI_09081, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18917 BF_2 110.70 1.66 3082 642930226 XP_008196308.1 1699 2.0e-186 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 606 4.4e-61 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- KOG1250 Threonine/serine dehydratases Cluster-8309.18921 BF_2 3.00 0.43 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18922 BF_2 2.00 0.80 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18923 BF_2 227.60 4.62 2349 642930369 XP_008196368.1 2381 1.2e-265 PREDICTED: dymeclin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q293C2 1460 3.2e-160 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2225 Proteins containing regions of low-complexity Cluster-8309.18924 BF_2 11.00 7.29 345 533205654 XP_005415280.1 234 1.6e-17 PREDICTED: cytochrome P450 2D6-like [Chinchilla lanigera] 821390288 KR005635.1 344 8.45458e-179 Homo sapiens nonfunctional cytochrome P450 2D6 (CYP2D6) gene, CYP2D6*69 allele, complete cds K07414 CYP2D cytochrome P450, family 2, subfamily D http://www.genome.jp/dbget-bin/www_bget?ko:K07414 Q2XNC9 229 2.6e-18 Cytochrome P450 2D6 OS=Pan paniscus GN=CYP2D6 PE=3 SV=1 PF15360 APJ endogenous ligand GO:0007165 signal transduction GO:0005179//GO:0031704 hormone activity//apelin receptor binding -- -- -- -- Cluster-8309.18925 BF_2 13.45 1.45 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18930 BF_2 87.82 2.97 1524 189237437 XP_001815618.1 890 6.2e-93 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 346 3.1e-31 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18934 BF_2 76.99 0.53 6315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07928//PF08047 Vps54-like protein//Histidine operon leader peptide GO:0000105//GO:0042147 histidine biosynthetic process//retrograde transport, endosome to Golgi -- -- -- -- -- -- Cluster-8309.18935 BF_2 106.47 0.74 6335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07928//PF08047 Vps54-like protein//Histidine operon leader peptide GO:0042147//GO:0000105 retrograde transport, endosome to Golgi//histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.18938 BF_2 23.25 0.43 2554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18946 BF_2 109.00 1.99 2580 642922330 XP_008193115.1 447 2.5e-41 PREDICTED: uncharacterized protein LOC103312948 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18949 BF_2 42.00 2.59 966 -- -- -- -- -- 156765693 AK289078.1 927 0 Oryza sativa Japonica Group cDNA, clone: J090095C12, full insert sequence -- -- -- -- Q43009 1531 7.6e-169 Sucrose synthase 3 OS=Oryza sativa subsp. japonica GN=SUS3 PE=1 SV=2 PF00862 Sucrose synthase GO:0005985//GO:0005982 sucrose metabolic process//starch metabolic process GO:0016157 sucrose synthase activity -- -- -- -- Cluster-8309.18954 BF_2 15.21 0.32 2297 91094355 XP_970090.1 787 8.2e-81 PREDICTED: ATM interactor [Tribolium castaneum]>gi|270014934|gb|EFA11382.1| hypothetical protein TcasGA2_TC011542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S1 196 1.1e-13 ATM interactor OS=Mus musculus GN=Atmin PE=2 SV=2 PF00096//PF16622//PF13912 Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.18955 BF_2 3.00 0.31 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18956 BF_2 3.00 0.33 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18958 BF_2 401.73 3.32 5342 642928360 XP_972133.2 2245 1.7e-249 PREDICTED: ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [Tribolium castaneum] 768408887 XM_011551471.1 79 2.9511e-30 PREDICTED: Plutella xylostella igLON family member 5-like (LOC105381682), mRNA K05655 ABCB8 ATP-binding cassette, subfamily B (MDR/TAP), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K05655 B2GUP8 1544 1.3e-169 ATP-binding cassette sub-family B member 8, mitochondrial OS=Xenopus tropicalis GN=abcb8 PE=2 SV=1 PF03193//PF00005//PF06414//PF13895//PF01583//PF13304//PF00664//PF06472//PF12814 Protein of unknown function, DUF258//ABC transporter//Zeta toxin//Immunoglobulin domain//Adenylylsulphate kinase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//ABC transporter transmembrane region 2//Meiotic cell cortex C-terminal pleckstrin homology GO:0055085//GO:0006810//GO:0032065//GO:0006144//GO:0000103 transmembrane transport//transport//cortical protein anchoring//purine nucleobase metabolic process//sulfate assimilation GO:0016887//GO:0016301//GO:0042626//GO:0005524//GO:0003924//GO:0005525//GO:0005543//GO:0004020//GO:0005515 ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//GTP binding//phospholipid binding//adenylylsulfate kinase activity//protein binding GO:0005938//GO:0016021 cell cortex//integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-8309.18960 BF_2 150.13 2.75 2567 189235643 XP_967729.2 1570 1.5e-171 PREDICTED: metallophosphoesterase 1 [Tribolium castaneum]>gi|270004406|gb|EFA00854.1| hypothetical protein TcasGA2_TC003757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZK82 806 2.4e-84 Metallophosphoesterase 1 OS=Gallus gallus GN=MPPE1 PE=2 SV=1 PF00599//PF00149 Influenza Matrix protein (M2)//Calcineurin-like phosphoesterase GO:0015992 proton transport GO:0016787//GO:0015078 hydrolase activity//hydrogen ion transmembrane transporter activity GO:0055036//GO:0033644 virion membrane//host cell membrane KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.18963 BF_2 2.00 0.48 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18964 BF_2 10.00 2.58 449 444523192 ELV13459.1 489 5.8e-47 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Tupaia chinensis] 383087749 NG_012113.2 449 0 Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), RefSeqGene (LRG_310) on chromosome 3 K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 P32871 484 9.0e-48 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Bos taurus GN=PIK3CA PE=1 SV=1 PF03719//PF00454 Ribosomal protein S5, C-terminal domain//Phosphatidylinositol 3- and 4-kinase GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0016773 structural constituent of ribosome//phosphotransferase activity, alcohol group as acceptor GO:0005840 ribosome KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) Cluster-8309.18965 BF_2 2.53 0.55 480 91094083 XP_970629.1 469 1.3e-44 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270016176|gb|EFA12624.1| hypothetical protein TcasGA2_TC010257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 312 8.5e-28 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.18967 BF_2 74.57 4.26 1019 91085583 XP_968374.1 649 3.7e-65 PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|642926992|ref|XP_008195095.1| PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|270010071|gb|EFA06519.1| hypothetical protein TcasGA2_TC009422 [Tribolium castaneum] -- -- -- -- -- K06693 PSMD9 26S proteasome non-ATPase regulatory subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06693 Q9WTV5 456 3.6e-44 26S proteasome non-ATPase regulatory subunit 9 OS=Rattus norvegicus GN=Psmd9 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3129 26S proteasome regulatory complex, subunit PSMD9 Cluster-8309.18972 BF_2 1140.58 28.12 1984 728418014 AIY68354.1 1370 1.8e-148 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 P35502 583 1.3e-58 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF04048//PF07859 Sec8 exocyst complex component specific domain//alpha/beta hydrolase fold GO:0008152//GO:0006904//GO:0015031 metabolic process//vesicle docking involved in exocytosis//protein transport GO:0016787 hydrolase activity GO:0000145 exocyst -- -- Cluster-8309.18973 BF_2 33.00 4.36 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18974 BF_2 8.00 0.62 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18975 BF_2 18.00 0.67 1406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18976 BF_2 5.00 1.54 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07669 Eco57I restriction-modification methylase GO:0006304 DNA modification GO:0003677//GO:0003824 DNA binding//catalytic activity -- -- -- -- Cluster-8309.18977 BF_2 53.00 0.61 3938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18978 BF_2 26.55 0.71 1851 642914292 XP_008201625.1 204 2.7e-13 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q23977 130 4.2e-06 Dual specificity mitogen-activated protein kinase kinase hemipterous OS=Drosophila melanogaster GN=hep PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.18979 BF_2 2.00 0.33 539 768413451 XP_011568846.1 338 2.2e-29 PREDICTED: ecdysteroid-regulated 16 kDa protein-like [Plutella xylostella] -- -- -- -- -- K13443 NPC2 Niemann-Pick C2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K13443 P61916 297 5.2e-26 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 PF07732 Multicopper oxidase -- -- GO:0005507 copper ion binding -- -- -- -- Cluster-8309.18981 BF_2 23.13 0.39 2746 91087387 XP_975653.1 1436 5.5e-156 PREDICTED: glucosylceramidase-like [Tribolium castaneum] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q70KH2 942 4.3e-100 Glucosylceramidase OS=Sus scrofa GN=GBA PE=3 SV=1 PF02055 O-Glycosyl hydrolase family 30 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.18985 BF_2 435.24 6.22 3213 270009523 EFA05971.1 362 2.2e-31 hypothetical protein TcasGA2_TC008793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18986 BF_2 222.65 7.89 1468 270016714 EFA13160.1 144 1.9e-06 hypothetical protein TcasGA2_TC015964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05369//PF08777//PF00076 Monomethylamine methyltransferase MtmB//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0032259 methylation GO:0003676//GO:0008168//GO:0003723 nucleic acid binding//methyltransferase activity//RNA binding -- -- -- -- Cluster-8309.18987 BF_2 29.99 0.96 1590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18988 BF_2 4.00 0.75 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18989 BF_2 4.00 0.52 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.18990 BF_2 118.30 0.93 5588 642915691 XP_008190761.1 2700 3.0e-302 PREDICTED: cyclic nucleotide-gated cation channel subunit A [Tribolium castaneum] 170060746 XM_001865903.1 397 0 Culex quinquefasciatus cyclic-nucleotide-gated cation channel, mRNA K04950 CNGA3 cyclic nucleotide gated channel alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04950 Q24278 2171 2.7e-242 Cyclic nucleotide-gated cation channel subunit A OS=Drosophila melanogaster GN=CngA PE=2 SV=2 PF07926//PF05929//PF01105//PF00520 TPR/MLP1/MLP2-like protein//Phage capsid scaffolding protein (GPO) serine peptidase//emp24/gp25L/p24 family/GOLD//Ion transport protein GO:0006606//GO:0006811//GO:0019069//GO:0055085//GO:0006810 protein import into nucleus//ion transport//viral capsid assembly//transmembrane transport//transport GO:0005216 ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.18992 BF_2 382.95 4.84 3599 270008878 EFA05326.1 1127 4.9e-120 hypothetical protein TcasGA2_TC015490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 347 5.6e-31 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF15957//PF03067//PF04277//PF00089 Commissureless//Chitin binding domain//Oxaloacetate decarboxylase, gamma chain//Trypsin GO:0006814//GO:0006508//GO:0071436//GO:0006090//GO:0007411//GO:0006525//GO:0006560 sodium ion transport//proteolysis//sodium ion export//pyruvate metabolic process//axon guidance//arginine metabolic process//proline metabolic process GO:0015081//GO:0004252//GO:0008948 sodium ion transmembrane transporter activity//serine-type endopeptidase activity//oxaloacetate decarboxylase activity GO:0016020//GO:0019028 membrane//viral capsid -- -- Cluster-8309.19002 BF_2 2.32 0.62 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19004 BF_2 167.59 3.86 2103 642912946 XP_008201319.1 2312 1.1e-257 PREDICTED: integrator complex subunit 10 [Tribolium castaneum] -- -- -- -- -- K13147 INTS10 integrator complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13147 Q6TNU3 462 1.5e-44 Integrator complex subunit 10 OS=Danio rerio GN=ints10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19005 BF_2 31.53 0.43 3332 91080171 XP_970238.1 3368 0.0e+00 PREDICTED: transportin-3 [Tribolium castaneum] 658920433 XM_008401725.1 75 3.06755e-28 PREDICTED: Poecilia reticulata transportin 3 (tnpo3), mRNA K15436 TRPO3, MTR10 transportin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K15436 Q6P2B1 1825 2.1e-202 Transportin-3 OS=Mus musculus GN=Tnpo3 PE=1 SV=1 PF03810//PF05823//PF00452 Importin-beta N-terminal domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Apoptosis regulator proteins, Bcl-2 family GO:0042981//GO:0006886 regulation of apoptotic process//intracellular protein transport GO:0008536//GO:0008289 Ran GTPase binding//lipid binding -- -- KOG2081 Nuclear transport regulator Cluster-8309.19009 BF_2 249.00 20.04 807 91076710 XP_972261.1 739 1.1e-75 PREDICTED: ER membrane protein complex subunit 10 [Tribolium castaneum]>gi|270001865|gb|EEZ98312.1| hypothetical protein TcasGA2_TC000766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5D8P8 295 1.3e-25 ER membrane protein complex subunit 10 OS=Xenopus laevis GN=emc10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4827 Uncharacterized conserved protein Cluster-8309.19012 BF_2 237.41 3.11 3477 91094511 XP_971832.1 1219 1.0e-130 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.52879e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 O35737 650 3.9e-66 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus GN=Hnrnph1 PE=1 SV=3 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:1901363//GO:0003723//GO:0097159 nucleic acid binding//heterocyclic compound binding//RNA binding//organic cyclic compound binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.19013 BF_2 31.00 1.32 1269 91085531 XP_972280.1 1352 1.4e-146 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q5RBM6 1117 1.0e-120 Beta-ureidopropionase OS=Pongo abelii GN=UPB1 PE=2 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0808 Carbon-nitrogen hydrolase Cluster-8309.19019 BF_2 37.00 2.75 849 270008452 EFA04900.1 325 1.1e-27 hypothetical protein TcasGA2_TC014964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF02050//PF02216//PF17060 Septum formation initiator//Flagellar FliJ protein//B domain//Monopolar spindle protein 2 GO:0030474//GO:0071973//GO:0006935//GO:0009405//GO:0007049//GO:0071988 spindle pole body duplication//bacterial-type flagellum-dependent cell motility//chemotaxis//pathogenesis//cell cycle//protein localization to spindle pole body GO:0019865//GO:0003774 immunoglobulin binding//motor activity GO:0019814//GO:0016020//GO:0009288 immunoglobulin complex//membrane//bacterial-type flagellum -- -- Cluster-8309.19021 BF_2 113.00 2.53 2156 873232655 CEM05294.1 924 1.0e-96 unnamed protein product [Vitrella brassicaformis CCMP3155] 115466209 NM_001063239.1 2092 0 Oryza sativa Japonica Group Os06g0133000 (Os06g0133000) mRNA, complete cds -- -- -- -- A2Y8X2 3049 0.0e+00 Granule-bound starch synthase 1, chloroplastic/amyloplastic OS=Oryza sativa subsp. indica GN=WAXY PE=3 SV=2 PF05038//PF03808 Cytochrome Cytochrome b558 alpha-subunit//Glycosyl transferase WecB/TagA/CpsF family GO:0009058 biosynthetic process GO:0020037 heme binding -- -- -- -- Cluster-8309.19022 BF_2 1.00 1.66 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19023 BF_2 124.32 1.14 4864 189234041 XP_967848.2 2749 5.4e-308 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H2Y9 651 4.2e-66 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF07062//PF07690//PF03137//PF07648 Clc-like//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Kazal-type serine protease inhibitor domain GO:0006810//GO:0055085 transport//transmembrane transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.19024 BF_2 29.45 1.59 1062 642931615 XP_008196657.1 290 1.6e-23 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Tribolium castaneum] 807033681 XM_004529871.2 62 1.61336e-21 PREDICTED: Ceratitis capitata DNA-directed RNA polymerases I, II, and III subunit RPABC4 (LOC101457024), mRNA K03009 RPB12, POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 http://www.genome.jp/dbget-bin/www_bget?ko:K03009 Q3ZBC0 236 1.2e-18 DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Bos taurus GN=POLR2K PE=3 SV=1 PF03604//PF01155 DNA directed RNA polymerase, 7 kDa subunit//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006206//GO:0006144//GO:0006464//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//cellular protein modification process//transcription, DNA-templated GO:0016151//GO:0003899//GO:0003677 nickel cation binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG3507 DNA-directed RNA polymerase, subunit RPB7.0 Cluster-8309.19034 BF_2 6.00 1.14 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00096 BED zinc finger//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.19035 BF_2 40.56 0.49 3719 642911734 XP_008200718.1 1166 1.5e-124 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC660336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PD21 334 1.9e-29 SH2 domain-containing adapter protein B OS=Mus musculus GN=Shb PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19036 BF_2 28.77 0.63 2194 478256367 ENN76557.1 2591 5.1e-290 hypothetical protein YQE_07008, partial [Dendroctonus ponderosae] -- -- -- -- -- K10455 KLHL18 kelch-like protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K10455 O94889 1471 1.6e-161 Kelch-like protein 18 OS=Homo sapiens GN=KLHL18 PE=1 SV=3 PF00651//PF07646//PF01344 BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.19039 BF_2 13.00 1.47 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19041 BF_2 10.00 2.22 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19045 BF_2 20.58 0.37 2605 826414790 XP_012522093.1 785 1.6e-80 PREDICTED: calpain-B isoform X3 [Monomorium pharaonis] 805805104 XM_003705388.2 60 5.21588e-20 PREDICTED: Megachile rotundata calpain-A (LOC100882339), transcript variant X9, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q11002 740 1.1e-76 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF00036//PF13405//PF13833//PF13499//PF13202//PF00648 EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair//EF hand//Calpain family cysteine protease GO:0006508 proteolysis GO:0005509//GO:0004198 calcium ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.19046 BF_2 23.01 0.52 2135 91082383 XP_968748.1 190 1.3e-11 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19048 BF_2 10.64 0.52 1149 675380592 KFM73494.1 196 1.4e-12 hypothetical protein X975_07201, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19052 BF_2 288.77 4.78 2813 478250729 ENN71221.1 2624 9.8e-294 hypothetical protein YQE_12149, partial [Dendroctonus ponderosae] -- -- -- -- -- K00784 rnz ribonuclease Z http://www.genome.jp/dbget-bin/www_bget?ko:K00784 Q8MKW7 1185 2.9e-128 Ribonuclease Z, mitochondrial OS=Drosophila melanogaster GN=JhI-1 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG2121 Predicted metal-dependent hydrolase (beta-lactamase superfamily) Cluster-8309.19055 BF_2 39.58 0.54 3340 189239531 XP_975588.2 1305 1.0e-140 PREDICTED: myb-related protein B isoform X1 [Tribolium castaneum] 817200908 XM_012420764.1 89 5.07326e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 6.3e-45 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.19056 BF_2 33.93 1.53 1212 478257181 ENN77344.1 377 1.5e-33 hypothetical protein YQE_06170, partial [Dendroctonus ponderosae]>gi|546681413|gb|ERL91510.1| hypothetical protein D910_08840 [Dendroctonus ponderosae] -- -- -- -- -- K10263 FBXW5 F-box and WD-40 domain protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10263 Q969U6 261 1.8e-21 F-box/WD repeat-containing protein 5 OS=Homo sapiens GN=FBXW5 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.19058 BF_2 43.00 0.47 4091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19059 BF_2 89.00 0.86 4638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01095 Pectinesterase GO:0005985//GO:0005982//GO:0042545 sucrose metabolic process//starch metabolic process//cell wall modification GO:0030599 pectinesterase activity GO:0005618 cell wall -- -- Cluster-8309.19064 BF_2 10.00 0.81 804 13898841 AAK48894.1 569 5.5e-56 CUB-serine protease [Panulirus argus] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 Q05319 484 1.6e-47 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19065 BF_2 10.00 1.00 706 13898841 AAK48894.1 161 9.8e-09 CUB-serine protease [Panulirus argus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19066 BF_2 6.00 0.47 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02533 Photosystem II 4 kDa reaction centre component GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539 photosystem II//photosystem II reaction center -- -- Cluster-8309.19067 BF_2 43.00 4.27 708 332375510 AEE62896.1 168 1.5e-09 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7SIG2 138 1.9e-07 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19072 BF_2 1.00 17.99 219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19074 BF_2 469.00 8.94 2481 91087269 XP_975538.1 1592 4.0e-174 PREDICTED: acyl-CoA synthetase family member 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q3URE1 1093 1.2e-117 Acyl-CoA synthetase family member 3, mitochondrial OS=Mus musculus GN=Acsf3 PE=2 SV=2 PF00501//PF04117 AMP-binding enzyme//Mpv17 / PMP22 family GO:0008152 metabolic process GO:0003824 catalytic activity GO:0016021 integral component of membrane KOG1176 Acyl-CoA synthetase Cluster-8309.19079 BF_2 61.61 0.43 6348 642927278 XP_008195204.1 487 1.4e-45 PREDICTED: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19082 BF_2 27.69 0.31 4051 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19084 BF_2 215.70 5.36 1971 642917912 XP_008191379.1 993 9.2e-105 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQM8 481 8.8e-47 UDP-glucuronosyltransferase 1-7C OS=Mus musculus GN=Ugt1a7c PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.19086 BF_2 63.80 0.95 3095 91080681 XP_975202.1 1354 2.0e-146 PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|642919555|ref|XP_008191921.1| PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|270005851|gb|EFA02299.1| hypothetical protein TcasGA2_TC007964 [Tribolium castaneum] 665800505 XM_008549999.1 212 1.97926e-104 PREDICTED: Microplitis demolitor CCR4-NOT transcription complex subunit 7 (LOC103571729), transcript variant X3, mRNA K12581 CNOT7_8, CAF1, POP2 CCR4-NOT transcription complex subunit 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12581 Q9UIV1 1046 4.2e-112 CCR4-NOT transcription complex subunit 7 OS=Homo sapiens GN=CNOT7 PE=1 SV=3 PF04857//PF13482 CAF1 family ribonuclease//RNase_H superfamily -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG0304 mRNA deadenylase subunit Cluster-8309.19087 BF_2 79.00 2.48 1620 478257475 ENN77631.1 1606 6.2e-176 hypothetical protein YQE_05925, partial [Dendroctonus ponderosae]>gi|546679869|gb|ERL90257.1| hypothetical protein D910_07609 [Dendroctonus ponderosae] -- -- -- -- -- K15276 SLC35B2, PAPST1 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B2 http://www.genome.jp/dbget-bin/www_bget?ko:K15276 Q9VEI3 1083 1.1e-116 Adenosine 3'-phospho 5'-phosphosulfate transporter 1 OS=Drosophila melanogaster GN=sll PE=1 SV=1 PF00892//PF15220//PF08449 EamA-like transporter family//Hypoxia-inducible lipid droplet-associated//UAA transporter family GO:0008284//GO:0055085//GO:0010884//GO:0001819 positive regulation of cell proliferation//transmembrane transport//positive regulation of lipid storage//positive regulation of cytokine production -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1581 UDP-galactose transporter related protein Cluster-8309.1909 BF_2 3.00 0.37 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19092 BF_2 35.20 1.25 1468 282400160 NP_001164203.1 2146 1.4e-238 cannonball [Tribolium castaneum]>gi|270008125|gb|EFA04573.1| cannonball [Tribolium castaneum] 242007793 XM_002424662.1 181 1.5853e-87 Pediculus humanus corporis transcription initiation factor TFIID subunit, putative, mRNA K03130 TAF5 transcription initiation factor TFIID subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03130 P49846 1404 6.2e-154 Transcription initiation factor TFIID subunit 5 OS=Drosophila melanogaster GN=Taf5 PE=1 SV=1 PF04494//PF00400//PF00039 WD40 associated region in TFIID subunit, NTD2 domain//WD domain, G-beta repeat//Fibronectin type I domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005576//GO:0005634 extracellular region//nucleus KOG0263 Transcription initiation factor TFIID, subunit TAF5 (also component of histone acetyltransferase SAGA) Cluster-8309.19093 BF_2 289.15 5.31 2566 189241705 XP_967022.2 2062 1.3e-228 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q94502 1418 2.6e-155 Neutral alpha-glucosidase AB OS=Dictyostelium discoideum GN=modA PE=3 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.19094 BF_2 18.73 0.43 2095 91089481 XP_969353.1 1311 1.3e-141 PREDICTED: beta-glucuronidase [Tribolium castaneum]>gi|270011394|gb|EFA07842.1| hypothetical protein TcasGA2_TC005412 [Tribolium castaneum] 780679440 XM_011698908.1 35 3.3013e-06 PREDICTED: Wasmannia auropunctata beta-glucuronidase (LOC105455522), transcript variant X8, mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 795 3.6e-83 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF02837//PF00150//PF00703//PF02836 Glycosyl hydrolases family 2, sugar binding domain//Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, TIM barrel domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0003824 hydrolase activity, hydrolyzing O-glycosyl compounds//catalytic activity -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.19095 BF_2 230.28 6.15 1853 270011395 EFA07843.1 1948 1.6e-215 hypothetical protein TcasGA2_TC005413 [Tribolium castaneum] 780679440 XM_011698908.1 35 2.91348e-06 PREDICTED: Wasmannia auropunctata beta-glucuronidase (LOC105455522), transcript variant X8, mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 1206 7.1e-131 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF02836//PF02837//PF00150//PF00703 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2, sugar binding domain//Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolases family 2 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.19096 BF_2 51.90 1.28 1982 270011395 EFA07843.1 1948 1.7e-215 hypothetical protein TcasGA2_TC005413 [Tribolium castaneum] 780679440 XM_011698908.1 35 3.12021e-06 PREDICTED: Wasmannia auropunctata beta-glucuronidase (LOC105455522), transcript variant X8, mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 1206 7.6e-131 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF02836//PF00703//PF02837//PF00150 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.19097 BF_2 22.09 0.48 2205 270011395 EFA07843.1 1868 3.5e-206 hypothetical protein TcasGA2_TC005413 [Tribolium castaneum] 780679440 XM_011698908.1 35 3.47759e-06 PREDICTED: Wasmannia auropunctata beta-glucuronidase (LOC105455522), transcript variant X8, mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 1152 1.5e-124 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF02836//PF00703//PF02837//PF00150 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.19101 BF_2 150.00 2.01 3410 642930609 XP_008193909.1 1545 1.6e-168 PREDICTED: GPI ethanolamine phosphate transferase 2 [Tribolium castaneum] -- -- -- -- -- K05310 GPI7 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05310 Q5H8A4 563 4.7e-56 GPI ethanolamine phosphate transferase 2 OS=Homo sapiens GN=PIGG PE=1 SV=1 PF00884//PF01676//PF01663 Sulfatase//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0046872//GO:0003824//GO:0008484 metal ion binding//catalytic activity//sulfuric ester hydrolase activity -- -- KOG2125 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.19107 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19108 BF_2 205.00 17.19 786 270011202 EFA07650.1 792 7.4e-82 hypothetical protein TcasGA2_TC030561 [Tribolium castaneum] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 Q5R7D8 469 8.7e-46 Dynactin subunit 6 OS=Pongo abelii GN=DCTN6 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- KOG4042 Dynactin subunit p27/WS-3, involved in transport of organelles along microtubules Cluster-8309.19113 BF_2 37.65 0.53 3261 642924596 XP_008194357.1 1534 2.8e-167 PREDICTED: putative ATP-dependent RNA helicase DHX33 [Tribolium castaneum]>gi|270006741|gb|EFA03189.1| hypothetical protein TcasGA2_TC013109 [Tribolium castaneum] -- -- -- -- -- K17820 DHX33 ATP-dependent RNA helicase DHX33 http://www.genome.jp/dbget-bin/www_bget?ko:K17820 Q9H6R0 907 5.9e-96 Putative ATP-dependent RNA helicase DHX33 OS=Homo sapiens GN=DHX33 PE=1 SV=2 PF07652//PF00437//PF00270//PF04851//PF04408//PF01637//PF00005 Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//Archaeal ATPase//ABC transporter GO:0006810//GO:0019079 transport//viral genome replication GO:0003676//GO:0016887//GO:0008026//GO:0005524//GO:0004386//GO:0016787//GO:0003677 nucleic acid binding//ATPase activity//ATP-dependent helicase activity//ATP binding//helicase activity//hydrolase activity//DNA binding -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.19116 BF_2 11.00 1.83 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19117 BF_2 78.51 1.73 2186 478260966 ENN80570.1 1116 5.6e-119 hypothetical protein YQE_03010, partial [Dendroctonus ponderosae]>gi|478264265|gb|ENN82194.1| hypothetical protein YQE_01430, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- L7YAI7 291 1.1e-24 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 PF13443 Cro/C1-type HTH DNA-binding domain -- -- GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.19118 BF_2 20.49 1.62 817 189236450 XP_001814629.1 291 9.6e-24 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|270005935|gb|EFA02383.1| hypothetical protein TcasGA2_TC008060 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13443 Cro/C1-type HTH DNA-binding domain -- -- GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.19119 BF_2 181.34 2.27 3635 478250074 ENN70580.1 978 9.3e-103 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 98 5.48727e-41 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.5e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF08030//PF00175 Ferric reductase NAD binding domain//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.19128 BF_2 1.00 2.59 275 642914858 XP_008195062.1 166 1.0e-09 PREDICTED: uncharacterized protein LOC103313485 [Tribolium castaneum]>gi|270002307|gb|EEZ98754.1| hypothetical protein TcasGA2_TC001318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03033 Glycosyltransferase family 28 N-terminal domain GO:0030259//GO:0005975 lipid glycosylation//carbohydrate metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.19129 BF_2 68.14 1.02 3094 478255137 ENN75367.1 1626 5.7e-178 hypothetical protein YQE_08142, partial [Dendroctonus ponderosae] 642914874 XM_965920.3 58 8.02583e-19 PREDICTED: Tribolium castaneum protein inscuteable homolog (LOC659633), mRNA -- -- -- -- Q3HNM7 345 8.2e-31 Protein inscuteable homolog OS=Mus musculus GN=Insc PE=1 SV=2 PF00514//PF01066 Armadillo/beta-catenin-like repeat//CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0005515//GO:0016780 protein binding//phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane -- -- Cluster-8309.19130 BF_2 101.00 1.69 2792 270011683 EFA08131.1 627 3.6e-62 hypothetical protein TcasGA2_TC005735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2IA00 300 1.2e-25 Sperm flagellar protein 2 OS=Sus scrofa GN=SPEF2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19134 BF_2 72.51 2.00 1807 642931832 XP_008196749.1 1601 2.6e-175 PREDICTED: GPI inositol-deacylase [Tribolium castaneum]>gi|270011727|gb|EFA08175.1| hypothetical protein TcasGA2_TC005802 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q75T13 693 2.1e-71 GPI inositol-deacylase OS=Homo sapiens GN=PGAP1 PE=1 SV=1 PF07819//PF01764 PGAP1-like protein//Lipase (class 3) GO:0006505//GO:0009987//GO:0006629//GO:0006886 GPI anchor metabolic process//cellular process//lipid metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG3724 Negative regulator of COPII vesicle formation Cluster-8309.19136 BF_2 1.00 0.65 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19140 BF_2 9.00 0.91 700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19142 BF_2 74.00 7.98 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19144 BF_2 47.07 1.71 1437 642926196 XP_008194825.1 753 4.5e-77 PREDICTED: uncharacterized protein LOC103313412 [Tribolium castaneum] 462343094 APGK01035499.1 48 1.33323e-13 Dendroctonus ponderosae Seq01035509, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02284 Cytochrome c oxidase subunit Va GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0045277 mitochondrial inner membrane//respiratory chain complex IV -- -- Cluster-8309.19145 BF_2 53.00 1.31 1976 751799211 XP_011209556.1 727 6.4e-74 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 4.9e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF13606//PF00887//PF00023//PF00076//PF06839//PF16367 Ankyrin repeat//Acyl CoA binding protein//Ankyrin repeat//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//GRF zinc finger//RNA recognition motif -- -- GO:0005515//GO:0008270//GO:0000062//GO:0003676 protein binding//zinc ion binding//fatty-acyl-CoA binding//nucleic acid binding -- -- -- -- Cluster-8309.19146 BF_2 143.00 2.91 2340 189241943 XP_971607.2 1924 1.2e-212 PREDICTED: uncharacterized aarF domain-containing protein kinase 1 [Tribolium castaneum]>gi|270015338|gb|EFA11786.1| hypothetical protein TcasGA2_TC008565 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q5ZMT7 1163 8.7e-126 Uncharacterized aarF domain-containing protein kinase 1 OS=Gallus gallus GN=ADCK1 PE=2 SV=1 PF09788//PF00069 Transmembrane protein 55A//Protein kinase domain GO:0046856//GO:0006468 phosphatidylinositol dephosphorylation//protein phosphorylation GO:0004672//GO:0034597//GO:0016772//GO:0005524 protein kinase activity//phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//transferase activity, transferring phosphorus-containing groups//ATP binding -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.19149 BF_2 486.83 6.79 3288 478250173 ENN70676.1 1254 8.3e-135 hypothetical protein YQE_12621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q88168 578 8.3e-58 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.19153 BF_2 29.00 0.44 3022 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19154 BF_2 11.00 0.80 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19156 BF_2 615.00 6.52 4233 478260373 ENN80120.1 3403 0.0e+00 hypothetical protein YQE_03479, partial [Dendroctonus ponderosae] -- -- -- -- -- K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 O35604 1867 3.7e-207 Niemann-Pick C1 protein OS=Mus musculus GN=Npc1 PE=1 SV=2 PF03176//PF02460 MMPL family//Patched family GO:0007165 signal transduction GO:0008158 hedgehog receptor activity GO:0016020 membrane KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.19157 BF_2 270.00 3.58 3441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19159 BF_2 138.31 5.83 1280 642910728 XP_008193385.1 1731 1.6e-190 PREDICTED: bifunctional arginine demethylase and lysyl-hydroxylase PSR isoform X2 [Tribolium castaneum] 805820060 XM_003707252.2 125 1.85893e-56 PREDICTED: Megachile rotundata bifunctional arginine demethylase and lysyl-hydroxylase PSR (LOC100883265), transcript variant X1, mRNA K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q9VD28 1377 7.3e-151 Bifunctional arginine demethylase and lysyl-hydroxylase PSR OS=Drosophila melanogaster GN=PSR PE=2 SV=1 PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.19160 BF_2 99.81 1.01 4414 91082575 XP_966727.1 790 7.1e-81 PREDICTED: bifunctional arginine demethylase and lysyl-hydroxylase PSR isoform X1 [Tribolium castaneum] -- -- -- -- -- K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q6PFM0 581 5.0e-58 Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 OS=Danio rerio GN=jmjd6 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain Cluster-8309.19161 BF_2 93.68 0.70 5854 91090340 XP_967097.1 1862 4.7e-205 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 807 4.1e-84 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF02259//PF00728 FAT domain//Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0005515//GO:0043169//GO:0004553 protein binding//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.19162 BF_2 8.84 0.53 991 546671469 ERL83770.1 450 4.2e-42 hypothetical protein D910_01007, partial [Dendroctonus ponderosae]>gi|546683774|gb|ERL93534.1| hypothetical protein D910_10823, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19164 BF_2 177.40 2.20 3656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19170 BF_2 42.00 2.43 1010 111572543 ABH10628.1 960 3.1e-101 laminin receptor [Litopenaeus vannamei] 194763915 XM_001964042.1 198 3.83004e-97 Drosophila ananassae GF21363 (Dana\GF21363), mRNA K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 A3RLT6 841 8.2e-89 40S ribosomal protein SA OS=Pinctada fucata PE=2 SV=1 PF07259//PF00318 ProSAAS precursor//Ribosomal protein S2 GO:0042254//GO:0010951//GO:0006412 ribosome biogenesis//negative regulation of endopeptidase activity//translation GO:0003735//GO:0004866 structural constituent of ribosome//endopeptidase inhibitor activity GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.19172 BF_2 274.32 10.10 1423 332376533 AEE63406.1 524 1.6e-50 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 O10274 365 1.8e-33 Putative tyrosine-protein phosphatase 1 OS=Orgyia pseudotsugata multicapsid polyhedrosis virus GN=PTP-1 PE=3 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.19174 BF_2 203.00 26.14 612 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01874 ATP:dephospho-CoA triphosphoribosyl transferase GO:0016310 phosphorylation GO:0046917//GO:0005524 triphosphoribosyl-dephospho-CoA synthase activity//ATP binding -- -- -- -- Cluster-8309.19175 BF_2 649.01 4.59 6206 642928875 XP_970065.3 4891 0.0e+00 PREDICTED: nuclear pore membrane glycoprotein 210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEM1 1807 4.9e-200 Nuclear pore membrane glycoprotein 210 OS=Homo sapiens GN=NUP210 PE=1 SV=3 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG1833 Nuclear pore complex, gp210 component Cluster-8309.19178 BF_2 34.00 1.51 1226 470445955 XP_004339901.1 1173 7.7e-126 aspartate aminotransferase, putative [Acanthamoeba castellanii str. Neff]>gi|440796784|gb|ELR17887.1| aspartate aminotransferase, putative [Acanthamoeba castellanii str. Neff] 115440074 NM_001050852.1 1226 0 Oryza sativa Japonica Group Os01g0760600 (Os01g0760600) mRNA, complete cds K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P37833 1923 3.4e-214 Aspartate aminotransferase, cytoplasmic OS=Oryza sativa subsp. japonica GN=Os01g0760600 PE=2 SV=1 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.19181 BF_2 316.00 7.05 2162 270014308 EFA10756.1 1299 3.3e-140 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 916 3.5e-97 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF01555//PF00067 DNA methylase//Cytochrome P450 GO:0055114//GO:0006306 oxidation-reduction process//DNA methylation GO:0020037//GO:0005506//GO:0016705//GO:0008170//GO:0003677 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//N-methyltransferase activity//DNA binding -- -- -- -- Cluster-8309.19183 BF_2 4.00 0.36 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19185 BF_2 73.00 3.87 1077 642933354 XP_008197380.1 735 4.1e-75 PREDICTED: uncharacterized protein LOC100142446 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0REX1 206 3.7e-15 Kynurenine formamidase OS=Bacillus thuringiensis (strain Al Hakam) GN=kynB PE=3 SV=1 PF04199 Putative cyclase GO:0046487//GO:0019441//GO:0006568 glyoxylate metabolic process//tryptophan catabolic process to kynurenine//tryptophan metabolic process GO:0004061 arylformamidase activity -- -- -- -- Cluster-8309.19188 BF_2 48.10 0.64 3430 646710326 KDR15870.1 2260 1.9e-251 Dual serine/threonine and tyrosine protein kinase, partial [Zootermopsis nevadensis] -- -- -- -- -- K16288 RIPK5, DSTYK receptor-interacting serine/threonine-protein kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16288 Q1L6Q1 2010 7.8e-224 Dual serine/threonine and tyrosine protein kinase OS=Apis mellifera GN=DSTYK PE=2 SV=1 PF07714//PF06293//PF01442//PF00069//PF04614 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Apolipoprotein A1/A4/E domain//Protein kinase domain//Pex19 protein family GO:0006869//GO:0006468//GO:0042157 lipid transport//protein phosphorylation//lipoprotein metabolic process GO:0005524//GO:0008289//GO:0004672//GO:0016773 ATP binding//lipid binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005777//GO:0016020//GO:0005576 peroxisome//membrane//extracellular region -- -- Cluster-8309.19191 BF_2 88.88 1.13 3577 642916865 XP_008199533.1 1429 4.6e-155 PREDICTED: transcription termination factor 2 [Tribolium castaneum]>gi|270003081|gb|EEZ99528.1| hypothetical protein TcasGA2_TC000110 [Tribolium castaneum] -- -- -- -- -- K15173 TTF2 transcription termination factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15173 P34739 1057 2.6e-113 Transcription termination factor 2 OS=Drosophila melanogaster GN=lds PE=1 SV=2 PF02742//PF03661//PF00176//PF04851 Iron dependent repressor, metal binding and dimerisation domain//Uncharacterised protein family (UPF0121)//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0046914//GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0046983 transition metal ion binding//ATP binding//nucleic acid binding//DNA binding//hydrolase activity//protein dimerization activity GO:0016021 integral component of membrane KOG4439 RNA polymerase II transcription termination factor TTF2/lodestar, DEAD-box superfamily Cluster-8309.19197 BF_2 1.00 0.72 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19200 BF_2 24.68 0.82 1550 642928334 XP_008195539.1 340 3.8e-29 PREDICTED: lysozyme-like [Tribolium castaneum] 332373991 BT127175.1 49 4.00566e-14 Dendroctonus ponderosae clone DPO0418_A10 unknown mRNA K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 246 1.2e-19 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.19201 BF_2 330.25 5.29 2900 270004382 EFA00830.1 718 1.0e-72 hypothetical protein TcasGA2_TC003718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1V2 388 7.9e-36 Cilia- and flagella-associated protein 52 OS=Homo sapiens GN=CFAP52 PE=1 SV=3 PF07967 C3HC zinc finger-like -- -- GO:0008270 zinc ion binding GO:0005634 nucleus KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.19204 BF_2 11.00 1.76 548 821033402 XP_012357823.1 643 9.8e-65 PREDICTED: 40S ribosomal protein S2-like isoform X2 [Nomascus leucogenys] 164689576 AK312173.1 548 0 Homo sapiens cDNA, FLJ92460, Homo sapiens ribosomal protein S2 (RPS2), mRNA K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P15880 643 4.0e-66 40S ribosomal protein S2 OS=Homo sapiens GN=RPS2 PE=1 SV=2 PF00333 Ribosomal protein S5, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-8309.19205 BF_2 2.00 0.56 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19208 BF_2 73.92 0.60 5432 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 1.1e-166 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF05504//PF00233//PF09771//PF00989//PF00072 Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188//PAS fold//Response regulator receiver domain GO:0009847//GO:0006355//GO:0035307//GO:0000160//GO:0007165//GO:0006144 spore germination//regulation of transcription, DNA-templated//positive regulation of protein dephosphorylation//phosphorelay signal transduction system//signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0016020//GO:0071595 membrane//Nem1-Spo7 phosphatase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.19213 BF_2 160.31 3.61 2144 642920703 XP_008192529.1 309 2.1e-25 PREDICTED: beta-taxilin-like isoform X2 [Tribolium castaneum]>gi|270006091|gb|EFA02539.1| hypothetical protein TcasGA2_TC008244 [Tribolium castaneum] -- -- -- -- -- K15712 TTC3 E3 ubiquitin-protein ligase TTC3 http://www.genome.jp/dbget-bin/www_bget?ko:K15712 Q86Y13 157 3.6e-09 E3 ubiquitin-protein ligase DZIP3 OS=Homo sapiens GN=DZIP3 PE=1 SV=2 PF04420//PF13639//PF03938//PF12861//PF11789//PF11744//PF14634//PF17123//PF12906//PF12678//PF00097 CHD5-like protein//Ring finger domain//Outer membrane protein (OmpH-like)//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc-finger of the MIZ type in Nse subunit//Aluminium activated malate transporter//zinc-RING finger domain//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0071816//GO:0016567//GO:0015743 tail-anchored membrane protein insertion into ER membrane//protein ubiquitination//malate transport GO:0051082//GO:0008270//GO:0046872//GO:0005515//GO:0004842 unfolded protein binding//zinc ion binding//metal ion binding//protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.19218 BF_2 251.48 25.18 705 91078608 XP_967155.1 398 3.2e-36 PREDICTED: mitochondrial import inner membrane translocase subunit Tim10 [Tribolium castaneum]>gi|270004056|gb|EFA00504.1| hypothetical protein TcasGA2_TC003366 [Tribolium castaneum] -- -- -- -- -- K17778 TIM10 mitochondrial import inner membrane translocase subunit TIM10 http://www.genome.jp/dbget-bin/www_bget?ko:K17778 Q9W2D6 317 3.3e-28 Mitochondrial import inner membrane translocase subunit Tim10 OS=Drosophila melanogaster GN=Tim10 PE=3 SV=1 -- -- GO:0045039 protein import into mitochondrial inner membrane GO:0046872 metal ion binding GO:0042719//GO:0005743 mitochondrial intermembrane space protein transporter complex//mitochondrial inner membrane KOG3480 Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 Cluster-8309.19219 BF_2 51.93 0.79 3036 91085437 XP_968834.1 682 1.6e-68 PREDICTED: protein zyg-11 homolog [Tribolium castaneum]>gi|270009168|gb|EFA05616.1| hypothetical protein TcasGA2_TC015823 [Tribolium castaneum] 462389525 APGK01019132.1 136 3.43726e-62 Dendroctonus ponderosae Seq01019142, whole genome shotgun sequence K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9C0D3 412 1.4e-38 Protein zyg-11 homolog B OS=Homo sapiens GN=ZYG11B PE=1 SV=2 PF00073//PF02985 picornavirus capsid protein//HEAT repeat -- -- GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0019028 viral capsid KOG3665 ZYG-1-like serine/threonine protein kinases Cluster-8309.19222 BF_2 2.00 0.55 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0003723//GO:0008270 RNA binding//zinc ion binding -- -- -- -- Cluster-8309.19223 BF_2 24.00 1.11 1189 768801663 AJV86879.1 734 6.0e-75 NADH dehydrogenase subunit 4 (mitochondrion) [Homo sapiens] 893712421 KT277306.1 1189 0 Homo sapiens haplogroup I2 mitochondrion, complete genome K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P03905 734 2.5e-76 NADH-ubiquinone oxidoreductase chain 4 OS=Homo sapiens GN=MT-ND4 PE=1 SV=1 PF00420//PF01059//PF00851 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L//NADH-ubiquinone oxidoreductase chain 4, amino terminus//Helper component proteinase GO:0006120//GO:0006508//GO:0042773//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//proteolysis//ATP synthesis coupled electron transport//oxidation-reduction process GO:0016651//GO:0004197 oxidoreductase activity, acting on NAD(P)H//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.19226 BF_2 61.67 0.87 3246 270014151 EFA10599.1 721 5.2e-73 hypothetical protein TcasGA2_TC012860 [Tribolium castaneum] 642936605 XM_970801.3 66 3.00872e-23 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 591 2.6e-59 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF00018//PF03248 SH3 domain//Rer1 family -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19227 BF_2 16.22 0.44 1818 91091328 XP_975894.1 977 6.1e-103 PREDICTED: protein RER1 isoform X2 [Tribolium castaneum] 642936605 XM_970801.3 214 8.92109e-106 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 658 2.4e-67 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19228 BF_2 736.42 22.31 1668 91091328 XP_975894.1 977 5.6e-103 PREDICTED: protein RER1 isoform X2 [Tribolium castaneum] 642936605 XM_970801.3 214 8.17058e-106 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 658 2.2e-67 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19230 BF_2 176.61 4.87 1805 270014151 EFA10599.1 884 3.7e-92 hypothetical protein TcasGA2_TC012860 [Tribolium castaneum] 642936605 XM_970801.3 211 4.12032e-104 PREDICTED: Tribolium castaneum protein RER1 (LOC660276), transcript variant X2, mRNA -- -- -- -- Q5ZHM5 626 1.2e-63 Protein RER1 OS=Gallus gallus GN=RER1 PE=2 SV=1 PF03248//PF00018 Rer1 family//SH3 domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1688 Golgi proteins involved in ER retention (RER) Cluster-8309.19232 BF_2 94.00 2.61 1791 330802303 XP_003289158.1 155 1.2e-07 hypothetical protein DICPUDRAFT_88372 [Dictyostelium purpureum]>gi|325080781|gb|EGC34322.1| hypothetical protein DICPUDRAFT_88372 [Dictyostelium purpureum] 115473358 NM_001066813.1 1779 0 Oryza sativa Japonica Group Os07g0616800 (Os07g0616800) mRNA, complete cds -- -- -- -- P31924 2589 2.9e-291 Sucrose synthase 1 OS=Oryza sativa subsp. japonica GN=SUS1 PE=1 SV=1 PF05196//PF00862 PTN/MK heparin-binding protein family, N-terminal domain//Sucrose synthase GO:0007165//GO:0005982//GO:0040007//GO:0005985//GO:0008283 signal transduction//starch metabolic process//growth//sucrose metabolic process//cell proliferation GO:0008083//GO:0016157 growth factor activity//sucrose synthase activity -- -- -- -- Cluster-8309.19235 BF_2 149.00 5.93 1339 332374332 AEE62307.1 1195 2.4e-128 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28EM8 363 2.9e-33 LETM1 domain-containing protein 1 OS=Xenopus tropicalis GN=letmd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19237 BF_2 2.00 0.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19238 BF_2 86.00 2.72 1610 571032317 AHF21594.1 602 1.6e-59 NADH dehydrogenase subunit 5 (mitochondrion) [Allothyrus sp. LamingtonNP-QMS95173] 510937390 KC812618.1 150 2.97818e-70 Samia cynthia cynthia mitochondrion, complete genome K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 Q9ZYM7 498 7.7e-49 NADH-ubiquinone oxidoreductase chain 5 OS=Rhipicephalus sanguineus GN=ND5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-8309.19243 BF_2 49.52 1.19 2021 91095049 XP_972102.1 649 7.3e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 2.6e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19244 BF_2 434.77 6.31 3169 91085955 XP_971224.1 3102 0.0e+00 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q80V86 755 2.4e-78 Integrator complex subunit 8 OS=Mus musculus GN=Ints8 PE=2 SV=1 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.1925 BF_2 3.00 0.38 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19251 BF_2 89.30 2.56 1745 642932969 XP_008197210.1 2029 6.0e-225 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 642932968 XM_008198988.1 486 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaw (LOC658450), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1524 8.9e-168 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF00520//PF02214 Ion transport protein//BTB/POZ domain GO:0051260//GO:0006811//GO:0055085 protein homooligomerization//ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.19252 BF_2 247.05 3.00 3729 642919204 XP_008191779.1 1144 5.4e-122 PREDICTED: POU domain protein 2 [Tribolium castaneum] 820841750 XM_012483764.1 143 5.43491e-66 PREDICTED: Apis florea POU domain protein 2, isoform A-like (LOC100872881), transcript variant X3, mRNA K09364 POU2F, OTF POU domain transcription factor, class 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09364 P31368 732 1.3e-75 Protein nubbin OS=Drosophila melanogaster GN=nub PE=2 SV=1 PF05434//PF00046//PF05920//PF00157 TMEM9//Homeobox domain//Homeobox KN domain//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.19257 BF_2 38.00 1.67 1238 2655025 AAC52017.1 1869 1.5e-206 phosphatase and tensin homolog 2 [Homo sapiens] 114841167 NG_001337.2 1201 0 Homo sapiens T cell receptor beta variable orphans on chromosome 9 (TRBV/OR9) on chromosome 9 K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60484 1847 2.2e-205 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens GN=PTEN PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases Cluster-8309.19260 BF_2 4.00 1.82 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19261 BF_2 85.00 12.27 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19262 BF_2 4.00 0.72 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19263 BF_2 10.00 1.82 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19265 BF_2 23.00 0.32 3257 641658932 XP_008180898.1 317 3.7e-26 PREDICTED: KRAB-A domain-containing protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6R2W3 218 4.6e-16 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19266 BF_2 8.60 0.87 700 332376138 AEE63209.1 390 2.7e-35 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 352 2.9e-32 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF05307//PF00089 Bundlin//Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0009289 pilus -- -- Cluster-8309.19267 BF_2 1.00 0.63 349 546683574 ERL93372.1 164 2.2e-09 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O97398 138 9.3e-08 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19269 BF_2 108.54 5.05 1187 189237921 XP_001811995.1 740 1.2e-75 PREDICTED: sperm-associated antigen 7 [Tribolium castaneum]>gi|270006673|gb|EFA03121.1| hypothetical protein TcasGA2_TC013031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SYJ9 365 1.5e-33 Sperm-associated antigen 7 homolog OS=Danio rerio GN=spag7 PE=1 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19272 BF_2 3.00 2.44 331 815766593 XP_012220855.1 313 1.1e-26 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105671347, partial [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19273 BF_2 325.00 51.13 553 16930529 AAL31950.1 266 5.1e-21 CDH1-D, partial [Gallus gallus] 75858875 DQ144649.1 273 4.13667e-139 Uroobovella sp. OSAL014198 18S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19276 BF_2 28.00 0.86 1654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19278 BF_2 23.94 0.43 2637 546686075 ERL95475.1 239 3.3e-17 hypothetical protein D910_12737 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19281 BF_2 6.29 0.84 602 91077058 XP_968505.1 263 1.2e-20 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] -- -- -- -- -- K15042 KPNA1 importin subunit alpha-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15042 Q56R16 209 9.3e-16 Importin subunit alpha-6 OS=Rattus norvegicus GN=Kpna5 PE=2 SV=1 PF01749//PF16006//PF00514 Importin beta binding domain//Nucleolar and spindle-associated protein//Armadillo/beta-catenin-like repeat GO:0006606//GO:0000226//GO:0000281//GO:0015031//GO:0040001 protein import into nucleus//microtubule cytoskeleton organization//mitotic cytokinesis//protein transport//establishment of mitotic spindle localization GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0005819//GO:0005737//GO:0005634//GO:0005874 spindle//cytoplasm//nucleus//microtubule KOG0166 Karyopherin (importin) alpha Cluster-8309.19282 BF_2 25.45 0.35 3338 642921567 XP_008192427.1 2080 1.4e-230 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1127 1.9e-121 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF00515//PF13374//PF02891//PF00637//PF13176//PF06464//PF13181//PF00096 Tetratricopeptide repeat//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Region in Clathrin and VPS//Tetratricopeptide repeat//DMAP1-binding Domain//Tetratricopeptide repeat//Zinc finger, C2H2 type GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008134//GO:0005515//GO:0046872//GO:0008270 transcription factor binding//protein binding//metal ion binding//zinc ion binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.19283 BF_2 37.00 0.34 4855 91086061 XP_973912.1 2040 8.9e-226 PREDICTED: synaptotagmin-16 [Tribolium castaneum] -- -- -- -- -- K19328 SYT14_16 synaptotagmin-14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K19328 Q17RD7 822 6.3e-86 Synaptotagmin-16 OS=Homo sapiens GN=SYT16 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.19285 BF_2 34.00 1.17 1500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19289 BF_2 6.00 6.28 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19294 BF_2 274.75 6.43 2074 642917373 XP_001806886.2 862 1.5e-89 PREDICTED: N-alpha-acetyltransferase 10 [Tribolium castaneum]>gi|270003017|gb|EEZ99464.1| hypothetical protein TcasGA2_TC000030 [Tribolium castaneum] 675300535 KM377395.1 146 6.45172e-68 Pauropsalta sp. 8 CLO-2014 acetyltransferase (ARD1) gene, partial cds K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 P41227 699 4.9e-72 N-alpha-acetyltransferase 10 OS=Homo sapiens GN=NAA10 PE=1 SV=1 PF00583//PF13508//PF08445//PF13302//PF13673//PF12568 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3235 Subunit of the major N alpha-acetyltransferase Cluster-8309.19296 BF_2 63.29 1.27 2372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19298 BF_2 305.57 3.07 4450 642930899 XP_008196132.1 1306 1.1e-140 PREDICTED: protein suppressor of sable isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22293 356 6.2e-32 Protein suppressor of sable OS=Drosophila melanogaster GN=su(s) PE=1 SV=2 PF00642//PF06440 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DNA polymerase III, theta subunit GO:0006260 DNA replication GO:0046872//GO:0003887//GO:0003677 metal ion binding//DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.19299 BF_2 353.62 6.33 2625 546680798 ERL91004.1 1930 2.7e-213 hypothetical protein D910_08346 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q91WR3 275 9.1e-23 Activating signal cointegrator 1 complex subunit 2 OS=Mus musculus GN=Ascc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19302 BF_2 165.63 2.39 3192 189237765 XP_001812950.1 1454 5.2e-158 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|642924439|ref|XP_008194298.1| PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|270006791|gb|EFA03239.1| hypothetical protein TcasGA2_TC013171 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 O01735 1022 2.7e-109 Uncharacterized MFS-type transporter C09D4.1 OS=Caenorhabditis elegans GN=C09D4.1 PE=3 SV=2 PF03137//PF07690//PF00083 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.19303 BF_2 45.00 0.50 4076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19306 BF_2 89.00 4.88 1050 227018324 ACP18828.1 1058 1.4e-112 chitin deacetylase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19307 BF_2 8.00 0.42 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19310 BF_2 31.00 1.89 974 290783836 ADD62496.1 169 1.6e-09 gastrolith protein 10 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19312 BF_2 5.00 0.53 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19313 BF_2 47.00 0.53 4005 242012387 XP_002426914.1 735 1.5e-74 conserved hypothetical protein [Pediculus humanus corporis]>gi|212511143|gb|EEB14176.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q9N2M8 640 6.6e-65 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 PF00616//PF03376 GTPase-activator protein for Ras-like GTPase//Adenovirus E3B protein GO:0043087 regulation of GTPase activity -- -- GO:0016020 membrane KOG3816 Cell differentiation regulator of the Headcase family Cluster-8309.19314 BF_2 9.00 0.80 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19316 BF_2 10.00 0.57 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19321 BF_2 28.65 0.47 2847 642935081 XP_008197876.1 288 7.4e-23 PREDICTED: calmodulin-binding transcription activator 2-like isoform X2 [Tribolium castaneum] 642935084 XM_008199656.1 77 2.02242e-29 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.19322 BF_2 53.39 0.91 2744 642930915 XP_008196139.1 330 9.7e-28 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 139 5.6e-07 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 -- -- GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19323 BF_2 51.00 1.17 2116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19324 BF_2 33.77 0.33 4553 642916563 XP_008191711.1 329 2.1e-27 PREDICTED: uncharacterized protein LOC660226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NEL2 162 2.0e-09 Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens GN=SOWAHB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.19327 BF_2 33.42 0.44 3457 642935773 XP_966401.2 3513 0.0e+00 PREDICTED: trafficking protein particle complex subunit 10 [Tribolium castaneum]>gi|270013291|gb|EFA09739.1| hypothetical protein TcasGA2_TC011874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VFB7 1521 3.9e-167 Trafficking protein particle complex subunit 10 OS=Drosophila melanogaster GN=SIDL PE=1 SV=1 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG1931 Putative transmembrane protein Cluster-8309.19329 BF_2 11.75 0.51 1246 546673531 ERL85114.1 343 1.4e-29 hypothetical protein D910_02536 [Dendroctonus ponderosae] -- -- -- -- -- K02520 infC, MTIF3 translation initiation factor IF-3 http://www.genome.jp/dbget-bin/www_bget?ko:K02520 Q9CZD5 133 1.3e-06 Translation initiation factor IF-3, mitochondrial OS=Mus musculus GN=Mtif3 PE=1 SV=1 PF05198//PF00582//PF00707 Translation initiation factor IF-3, N-terminal domain//Universal stress protein family//Translation initiation factor IF-3, C-terminal domain GO:0006950//GO:0006413//GO:0006446 response to stress//translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.19330 BF_2 969.51 12.97 3415 189235374 XP_001809693.1 2197 3.9e-244 PREDICTED: potassium voltage-gated channel protein Shaker isoform X1 [Tribolium castaneum] 642916511 XM_001809641.2 1072 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X1, mRNA K05318 KCNAN potassium voltage-gated channel Shaker-related subfamily A, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05318 P08510 1926 4.2e-214 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF00520//PF00060 Ion transport protein//Ligand-gated ion channel GO:0055085//GO:0007165//GO:0006811//GO:0007268 transmembrane transport//signal transduction//ion transport//synaptic transmission GO:0005216//GO:0004970 ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.19334 BF_2 203.04 2.56 3601 91082339 XP_966549.1 5329 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC2 [Tribolium castaneum]>gi|270007487|gb|EFA03935.1| hypothetical protein TcasGA2_TC014075 [Tribolium castaneum] 719740584 XM_010211158.1 114 6.9324e-50 PREDICTED: Tinamus guttatus DNA-directed RNA polymerase III subunit RPC2 (LOC104564515), partial mRNA K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 P25167 4251 0.0e+00 DNA-directed RNA polymerase III subunit RPC2 OS=Drosophila melanogaster GN=RpIII128 PE=2 SV=2 PF04567//PF04561//PF04565//PF04566//PF04560//PF00562//PF04563 RNA polymerase Rpb2, domain 5//RNA polymerase Rpb2, domain 2//RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 4//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 6//RNA polymerase beta subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0032549 DNA binding//DNA-directed RNA polymerase activity//ribonucleoside binding GO:0005730 nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-8309.19335 BF_2 67.00 3.18 1169 478255798 ENN76006.1 503 3.6e-48 hypothetical protein YQE_07385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T635 303 2.3e-26 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.19338 BF_2 19.51 0.52 1856 642917903 XP_008191376.1 1043 1.4e-110 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 270 2.4e-22 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19339 BF_2 3.00 0.61 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1934 BF_2 37.00 2.13 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19340 BF_2 5.36 1.23 469 646718490 KDR20930.1 317 5.3e-27 hypothetical protein L798_03868 [Zootermopsis nevadensis] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 Q8CDJ3 187 2.6e-13 Beclin 1-associated autophagy-related key regulator OS=Mus musculus GN=Atg14 PE=1 SV=1 PF10186 Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy -- -- -- -- -- -- Cluster-8309.19342 BF_2 62.84 0.69 4108 642910693 XP_008200063.1 3431 0.0e+00 PREDICTED: neurogenic locus protein delta [Tribolium castaneum]>gi|270014506|gb|EFA10954.1| hypothetical protein TcasGA2_TC004114 [Tribolium castaneum] 642910692 XM_008201841.1 779 0 PREDICTED: Tribolium castaneum neurogenic locus protein delta (LOC658619), mRNA K06051 DLL delta http://www.genome.jp/dbget-bin/www_bget?ko:K06051 Q9IAT6 1432 9.8e-157 Delta-like protein C OS=Danio rerio GN=dlc PE=2 SV=1 PF01414//PF07657//PF07645//PF00008 Delta serrate ligand//N terminus of Notch ligand//Calcium-binding EGF domain//EGF-like domain GO:0007219//GO:0007275//GO:0007154 Notch signaling pathway//multicellular organismal development//cell communication GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.19347 BF_2 60.56 0.52 5122 270013369 EFA09817.1 818 4.7e-84 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q5VV67 169 3.5e-10 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Homo sapiens GN=PPRC1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19349 BF_2 510.45 8.48 2806 646716704 KDR19844.1 661 4.1e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.7e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.19350 BF_2 10.00 0.84 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19355 BF_2 17.47 0.32 2564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19357 BF_2 109.75 5.03 1199 189242493 XP_972306.2 1155 9.1e-124 PREDICTED: E3 ubiquitin-protein ligase RNF25 [Tribolium castaneum] -- -- -- -- -- K10640 RNF25, AO7 E3 ubiquitin-protein ligase RNF25 http://www.genome.jp/dbget-bin/www_bget?ko:K10640 Q9QZR0 455 5.6e-44 E3 ubiquitin-protein ligase RNF25 OS=Mus musculus GN=Rnf25 PE=1 SV=2 PF13639//PF00097//PF17123//PF05773//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RWD domain//zinc-RING finger domain -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG4445 Uncharacterized conserved protein, contains RWD domain Cluster-8309.19360 BF_2 70.20 0.63 4948 91089075 XP_971233.1 492 2.9e-46 PREDICTED: cell cycle checkpoint protein RAD17 [Tribolium castaneum]>gi|270011521|gb|EFA07969.1| hypothetical protein TcasGA2_TC005551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 165 9.7e-10 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.19362 BF_2 33.84 2.92 772 91089075 XP_971233.1 450 3.3e-42 PREDICTED: cell cycle checkpoint protein RAD17 [Tribolium castaneum]>gi|270011521|gb|EFA07969.1| hypothetical protein TcasGA2_TC005551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XT62 223 2.9e-17 Cell cycle checkpoint protein RAD17 OS=Chlorocebus aethiops GN=RAD17 PE=1 SV=1 PF00437//PF00004//PF00448//PF07728//PF05496//PF01580//PF00910//PF00005//PF03193//PF01637//PF06414//PF02367//PF04851 Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//SRP54-type protein, GTPase domain//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//FtsK/SpoIIIE family//RNA helicase//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Type III restriction enzyme, res subunit GO:0002949//GO:0006310//GO:0006810//GO:0006281//GO:0006614 tRNA threonylcarbamoyladenosine modification//DNA recombination//transport//DNA repair//SRP-dependent cotranslational protein targeting to membrane GO:0009378//GO:0003724//GO:0005525//GO:0003723//GO:0003677//GO:0000166//GO:0016301//GO:0016887//GO:0003924//GO:0005524//GO:0016787 four-way junction helicase activity//RNA helicase activity//GTP binding//RNA binding//DNA binding//nucleotide binding//kinase activity//ATPase activity//GTPase activity//ATP binding//hydrolase activity GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component Cluster-8309.19363 BF_2 7.78 0.61 820 91089075 XP_971233.1 450 3.5e-42 PREDICTED: cell cycle checkpoint protein RAD17 [Tribolium castaneum]>gi|270011521|gb|EFA07969.1| hypothetical protein TcasGA2_TC005551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75943 220 6.8e-17 Cell cycle checkpoint protein RAD17 OS=Homo sapiens GN=RAD17 PE=1 SV=2 PF01580//PF00910//PF00005//PF03193//PF01637//PF06414//PF04851//PF02367//PF00004//PF00437//PF00448//PF00735//PF07728//PF05496 FtsK/SpoIIIE family//RNA helicase//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin//Type III restriction enzyme, res subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//Septin//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus GO:0006614//GO:0006281//GO:0006810//GO:0006310//GO:0002949 SRP-dependent cotranslational protein targeting to membrane//DNA repair//transport//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0000166//GO:0016887//GO:0016301//GO:0005524//GO:0016787//GO:0003924//GO:0005525//GO:0003724//GO:0009378//GO:0003723//GO:0003677 nucleotide binding//ATPase activity//kinase activity//ATP binding//hydrolase activity//GTPase activity//GTP binding//RNA helicase activity//four-way junction helicase activity//RNA binding//DNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG1970 Checkpoint RAD17-RFC complex, RAD17/RAD24 component Cluster-8309.19366 BF_2 11.31 0.59 1083 270008369 EFA04817.1 339 3.4e-29 hypothetical protein TcasGA2_TC014867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NPA5 233 2.8e-18 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF06397//PF04988//PF13465//PF00096 Desulfoferrodoxin, N-terminal domain//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0005506//GO:0046872//GO:0003677 iron ion binding//metal ion binding//DNA binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.1937 BF_2 15.37 0.59 1381 642932128 XP_975308.3 453 2.7e-42 PREDICTED: monocarboxylate transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19371 BF_2 214.86 5.01 2080 478260883 ENN80520.1 273 3.0e-21 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.19372 BF_2 24.34 0.54 2185 478260883 ENN80520.1 273 3.1e-21 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.19374 BF_2 2.00 0.64 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19375 BF_2 2.27 0.40 526 546677066 ERL87975.1 607 1.4e-60 hypothetical protein D910_05363 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 392 4.9e-37 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.19378 BF_2 5.00 0.60 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19381 BF_2 468.00 20.57 1239 546675493 ERL86678.1 548 2.3e-53 hypothetical protein D910_04084 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19388 BF_2 14.04 0.33 2065 270006871 EFA03319.1 310 1.5e-25 hypothetical protein TcasGA2_TC013262 [Tribolium castaneum] 462314888 APGK01045625.1 35 3.25323e-06 Dendroctonus ponderosae Seq01045635, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19389 BF_2 243.76 4.14 2749 642923986 XP_008193958.1 2809 0.0e+00 PREDICTED: dystrobrevin beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70585 1164 7.8e-126 Dystrobrevin beta OS=Mus musculus GN=Dtnb PE=1 SV=3 PF07649//PF00569//PF06657 C1-like domain//Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57 GO:0055114 oxidation-reduction process GO:0008017//GO:0008270//GO:0047134 microtubule binding//zinc ion binding//protein-disulfide reductase activity GO:0045298 tubulin complex KOG4301 Beta-dystrobrevin Cluster-8309.1939 BF_2 2.00 0.32 550 18104948 NP_000973.2 849 1.3e-88 60S ribosomal protein L21 [Homo sapiens]>gi|354725920|ref|NP_001238973.1| 60S ribosomal protein L21 [Canis lupus familiaris]>gi|55629592|ref|XP_519455.1| PREDICTED: 60S ribosomal protein L21 [Pan troglodytes]>gi|109071615|ref|XP_001110998.1| PREDICTED: 60S ribosomal protein L21-like isoform 1 [Macaca mulatta]>gi|109120251|ref|XP_001095211.1| PREDICTED: 60S ribosomal protein L21-like isoform 3 [Macaca mulatta]>gi|109123323|ref|XP_001099217.1| PREDICTED: 60S ribosomal protein L21-like isoform 1 [Macaca mulatta]>gi|149712387|ref|XP_001495212.1| PREDICTED: 60S ribosomal protein L21-like [Equus caballus]>gi|149730048|ref|XP_001491540.1| PREDICTED: 60S ribosomal protein L21 isoform 1 [Equus caballus]>gi|291388155|ref|XP_002710693.1| PREDICTED: 60S ribosomal protein L21 [Oryctolagus cuniculus]>gi|291410354|ref|XP_002721461.1| PREDICTED: 60S ribosomal protein L21 [Oryctolagus cuniculus]>gi|296203598|ref|XP_002748988.1| PREDICTED: 60S ribosomal protein L21 [Callithrix jacchus]>gi|297274153|ref|XP_002800739.1| PREDICTED: 60S ribosomal protein L21-like [Macaca mulatta]>gi|297274155|ref|XP_002800740.1| PREDICTED: 60S ribosomal protein L21-like [Macaca mulatta]>gi|297274157|ref|XP_001094506.2| PREDICTED: 60S ribosomal protein L21-like isoform 1 [Macaca mulatta]>gi|297693724|ref|XP_002824157.1| PREDICTED: 60S ribosomal protein L21 [Pongo abelii]>gi|332242156|ref|XP_003270250.1| PREDICTED: 60S ribosomal protein L21 isoform X1 [Nomascus leucogenys]>gi|332242160|ref|XP_003270252.1| PREDICTED: 60S ribosomal protein L21 isoform X1 [Nomascus leucogenys]>gi|332841065|ref|XP_003339291.1| PREDICTED: 60S ribosomal protein L21 [Pan troglodytes]>gi|348583381|ref|XP_003477451.1| PREDICTED: 60S ribosomal protein L21 [Cavia porcellus]>gi|350589740|ref|XP_003482912.1| PREDICTED: 60S ribosomal protein L21 isoformX1 [Sus scrofa]>gi|350589742|ref|XP_003482913.1| PREDICTED: 60S ribosomal protein L21 isoformX2 [Sus scrofa]>gi|350589744|ref|XP_003482914.1| PREDICTED: 60S ribosomal protein L21 isoformX3 [Sus scrofa]>gi|350589746|ref|XP_003482915.1| PREDICTED: 60S ribosomal protein L21 isoformX4 [Sus scrofa]>gi|397495079|ref|XP_003818389.1| PREDICTED: 60S ribosomal protein L21 [Pan paniscus]>gi|397499434|ref|XP_003820458.1| PREDICTED: 60S ribosomal protein L21 [Pan paniscus]>gi|397503259|ref|XP_003822247.1| PREDICTED: 60S ribosomal protein L21 [Pan paniscus]>gi|402867353|ref|XP_003897822.1| PREDICTED: 60S ribosomal protein L21 [Papio anubis]>gi|402901630|ref|XP_003913748.1| PREDICTED: 60S ribosomal protein L21 [Papio anubis]>gi|402901632|ref|XP_003913749.1| PREDICTED: 60S ribosomal protein L21 [Papio anubis]>gi|402901634|ref|XP_003913750.1| PREDICTED: 60S ribosomal protein L21 [Papio anubis]>gi|402913519|ref|XP_003919235.1| PREDICTED: 60S ribosomal protein L21 [Papio anubis]>gi|410947151|ref|XP_003980316.1| PREDICTED: 60S ribosomal protein L21 [Felis catus]>gi|426374989|ref|XP_004054335.1| PREDICTED: 60S ribosomal protein L21 isoform 1 [Gorilla gorilla gorilla]>gi|426374991|ref|XP_004054336.1| PREDICTED: 60S ribosomal protein L21 isoform 2 [Gorilla gorilla gorilla]>gi|478522258|ref|XP_004435335.1| PREDICTED: 60S ribosomal protein L21 [Ceratotherium simum simum]>gi|488533693|ref|XP_004458569.1| PREDICTED: 60S ribosomal protein L21 [Dasypus novemcinctus]>gi|505785923|ref|XP_004604617.1| PREDICTED: 60S ribosomal protein L21 [Sorex araneus]>gi|507661940|ref|XP_004706464.1| PREDICTED: 60S ribosomal protein L21 [Echinops telfairi]>gi|507700502|ref|XP_004715206.1| PREDICTED: 60S ribosomal protein L21 [Echinops telfairi]>gi|507939376|ref|XP_004680219.1| PREDICTED: 60S ribosomal protein L21 [Condylura cristata]>gi|511925980|ref|XP_004782120.1| PREDICTED: 60S ribosomal protein L21 [Mustela putorius furo]>gi|511925982|ref|XP_004782121.1| PREDICTED: 60S ribosomal protein L21 [Mustela putorius furo]>gi|512985834|ref|XP_004854871.1| PREDICTED: 60S ribosomal protein L21 [Heterocephalus glaber]>gi|544427180|ref|XP_005552697.1| PREDICTED: 60S ribosomal protein L21-like [Macaca fascicularis]>gi|544434847|ref|XP_005556037.1| PREDICTED: 60S ribosomal protein L21-like [Macaca fascicularis]>gi|544502962|ref|XP_005585582.1| PREDICTED: 60S ribosomal protein L21 isoform X1 [Macaca fascicularis]>gi|544502964|ref|XP_005585583.1| PREDICTED: 60S ribosomal protein L21 isoform X2 [Macaca fascicularis]>gi|544502966|ref|XP_005585584.1| PREDICTED: 60S ribosomal protein L21 isoform X3 [Macaca fascicularis]>gi|544508583|ref|XP_005587971.1| PREDICTED: 60S ribosomal protein L21-like [Macaca fascicularis]>gi|545541592|ref|XP_005635442.1| PREDICTED: 60S ribosomal protein L21 isoform X1 [Canis lupus familiaris]>gi|545541594|ref|XP_005635443.1| PREDICTED: 60S ribosomal protein L21 isoform X2 [Canis lupus familiaris]>gi|545854324|ref|XP_005656892.1| PREDICTED: 60S ribosomal protein L21 isoform X5 [Sus scrofa]>gi|585188635|ref|XP_006745683.1| PREDICTED: 60S ribosomal protein L21-like isoform X1 [Leptonychotes weddellii]>gi|586447626|ref|XP_006831995.1| PREDICTED: 60S ribosomal protein L21-like [Chrysochloris asiatica]>gi|617600053|ref|XP_007522441.1| PREDICTED: 60S ribosomal protein L21 [Erinaceus europaeus]>gi|635024677|ref|XP_008019984.1| PREDICTED: 60S ribosomal protein L21 isoform X1 [Chlorocebus sabaeus]>gi|635024679|ref|XP_008019985.1| PREDICTED: 60S ribosomal protein L21 isoform X1 [Chlorocebus sabaeus]>gi|635091638|ref|XP_008010482.1| PREDICTED: 60S ribosomal protein L21 [Chlorocebus sabaeus]>gi|640802064|ref|XP_008057344.1| PREDICTED: 60S ribosomal protein L21 [Tarsius syrichta]>gi|640817532|ref|XP_008065609.1| PREDICTED: 60S ribosomal protein L21 [Tarsius syrichta]>gi|655884504|ref|XP_008273428.1| PREDICTED: 60S ribosomal protein L21 [Oryctolagus cuniculus]>gi|664774801|ref|XP_008506661.1| PREDICTED: 60S ribosomal protein L21 [Equus przewalskii]>gi|667346271|ref|XP_008563535.1| PREDICTED: 60S ribosomal protein L21 [Galeopterus variegatus]>gi|674102355|ref|XP_008823295.1| PREDICTED: 60S ribosomal protein L21 [Nannospalax galili]>gi|675662078|ref|XP_008996304.1| PREDICTED: 60S ribosomal protein L21 [Callithrix jacchus]>gi|675662080|ref|XP_008996305.1| PREDICTED: 60S ribosomal protein L21 [Callithrix jacchus]>gi|675662082|ref|XP_008996306.1| PREDICTED: 60S ribosomal protein L21 [Callithrix jacchus]>gi|675662084|ref|XP_008996307.1| PREDICTED: 60S ribosomal protein L21 [Callithrix jacchus]>gi|675747483|ref|XP_008969868.1| PREDICTED: 60S ribosomal protein L21 [Pan paniscus]>gi|675747486|ref|XP_008969869.1| PREDICTED: 60S ribosomal protein L21 [Pan paniscus]>gi|675747492|ref|XP_008969870.1| PREDICTED: 60S ribosomal protein L21 [Pan paniscus]>gi|685612504|ref|XP_009194431.1| PREDICTED: 60S ribosomal protein L21 [Papio anubis]>gi|686743321|ref|XP_009246789.1| PREDICTED: 60S ribosomal protein L21 [Pongo abelii]>gi|686743323|ref|XP_009246790.1| PREDICTED: 60S ribosomal protein L21 [Pongo abelii]>gi|686743325|ref|XP_009246791.1| PREDICTED: 60S ribosomal protein L21 [Pongo abelii]>gi|694953529|ref|XP_009425046.1| PREDICTED: 60S ribosomal protein L21 [Pan troglodytes]>gi|694953531|ref|XP_009425047.1| PREDICTED: 60S ribosomal protein L21 [Pan troglodytes]>gi|724914031|ref|XP_010379912.1| PREDICTED: 60S ribosomal protein L21 [Rhinopithecus roxellana]>gi|724914034|ref|XP_010379913.1| PREDICTED: 60S ribosomal protein L21 [Rhinopithecus roxellana]>gi|724969932|ref|XP_010357254.1| PREDICTED: 60S ribosomal protein L21 [Rhinopithecus roxellana]>gi|731215452|ref|XP_010622131.1| PREDICTED: 60S ribosomal protein L21 [Fukomys damarensis]>gi|731215454|ref|XP_010622132.1| PREDICTED: 60S ribosomal protein L21 [Fukomys damarensis]>gi|755764568|ref|XP_011284365.1| PREDICTED: 60S ribosomal protein L21 [Felis catus]>gi|759120175|ref|XP_011358511.1| PREDICTED: 60S ribosomal protein L21 [Pteropus vampyrus]>gi|795111708|ref|XP_011813832.1| PREDICTED: 60S ribosomal protein L21 [Colobus angolensis palliatus]>gi|795111715|ref|XP_011813840.1| PREDICTED: 60S ribosomal protein L21 [Colobus angolensis palliatus]>gi|795111722|ref|XP_011813849.1| PREDICTED: 60S ribosomal protein L21 [Colobus angolensis palliatus]>gi|795159192|ref|XP_011796305.1| PREDICTED: 60S ribosomal protein L21 [Colobus angolensis palliatus]>gi|795229242|ref|XP_011807048.1| PREDICTED: 60S ribosomal protein L21 [Colobus angolensis palliatus]>gi|795254417|ref|XP_011855353.1| PREDICTED: 60S ribosomal protein L21 [Mandrillus leucophaeus]>gi|795254424|ref|XP_011855354.1| PREDICTED: 60S ribosomal protein L21 [Mandrillus leucophaeus]>gi|795393666|ref|XP_011753917.1| PREDICTED: 60S ribosomal protein L21 [Macaca nemestrina]>gi|795393670|ref|XP_011753918.1| PREDICTED: 60S ribosomal protein L21 [Macaca nemestrina]>gi|795393676|ref|XP_011753919.1| PREDICTED: 60S ribosomal protein L21 [Macaca nemestrina]>gi|795393680|ref|XP_011753920.1| PREDICTED: 60S ribosomal protein L21 [Macaca nemestrina]>gi|821130033|ref|XP_012386170.1| PREDICTED: 60S ribosomal protein L21 [Dasypus novemcinctus]>gi|823433526|ref|XP_012422918.1| PREDICTED: 60S ribosomal protein L21 [Odobenus rosmarus divergens]>gi|826271444|ref|XP_012514260.1| PREDICTED: 60S ribosomal protein L21 [Propithecus coquereli]>gi|826309495|ref|XP_012505345.1| PREDICTED: 60S ribosomal protein L21 [Propithecus coquereli]>gi|829850456|ref|XP_012637254.1| PREDICTED: 60S ribosomal protein L21 [Microcebus murinus]>gi|829900726|ref|XP_012590815.1| PREDICTED: 60S ribosomal protein L21 [Microcebus murinus]>gi|852781309|ref|XP_012882754.1| PREDICTED: 60S ribosomal protein L21 [Dipodomys ordii]>gi|859966026|ref|XP_012906217.1| PREDICTED: 60S ribosomal protein L21 [Mustela putorius furo]>gi|861462775|ref|XP_012931336.1| PREDICTED: 60S ribosomal protein L21 [Heterocephalus glaber]>gi|861462778|ref|XP_012931337.1| PREDICTED: 60S ribosomal protein L21 [Heterocephalus glaber]>gi|884944315|ref|XP_012998891.1| PREDICTED: 60S ribosomal protein L21 [Cavia porcellus]>gi|1172991|sp|P46778.2|RL21_HUMAN RecName: Full=60S ribosomal protein L21>gi|485601436|pdb|3J3B|T Chain T, Structure Of The Human 60s Ribosomal Proteins>gi|665764277|pdb|4CXD|T Chain T, Regulation Of The Mammalian Elongation Cycle By 40s Subunit Rolling: A Eukaryotic-specific Ribosome Rearrangement>gi|672884394|pdb|4UPX|T Chain T, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Pre-like State>gi|672884446|pdb|4UQ1|T Chain T, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Post-like State>gi|675970146|pdb|4W20|T Chain T, Structure Of The Mammalian 60s Ribosomal Subunit (this Entry Contains The Large Ribosomal Proteins)>gi|675970197|pdb|4W22|T Chain T, Structure Of The 80s Mammalian Ribosome Bound To Eef2 (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970288|pdb|4W25|T Chain T, Structure Of The Idle Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970341|pdb|4W27|T Chain T, Structure Of The Translating Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|550015|gb|AAA85655.1| ribosomal protein L21 [Homo sapiens]>gi|984143|emb|CAA61582.1| ribosomal protein L21 [Homo sapiens]>gi|12804403|gb|AAH01603.1| Ribosomal protein L21 [Homo sapiens]>gi|13960128|gb|AAH07505.1| Ribosomal protein L21 [Homo sapiens]>gi|17932946|dbj|BAB79464.1| ribosomal protein L21 [Homo sapiens]>gi|38649057|gb|AAH62981.1| Ribosomal protein L21 [Homo sapiens]>gi|47682411|gb|AAH70323.1| Ribosomal protein L21 [Homo sapiens]>gi|47682887|gb|AAH70184.1| Ribosomal protein L21 [Homo sapiens]>gi|47683073|gb|AAH70330.1| Ribosomal protein L21 [Homo sapiens]>gi|48146181|emb|CAG33313.1| RPL21 [Homo sapiens]>gi|48735343|gb|AAH71902.1| Ribosomal protein L21 [Homo sapiens]>gi|75775113|gb|AAI04668.1| Ribosomal protein L21 [Homo sapiens]>gi|119628800|gb|EAX08395.1| ribosomal protein L21, isoform CRA_a [Homo sapiens]>gi|119628803|gb|EAX08398.1| ribosomal protein L21, isoform CRA_a [Homo sapiens]>gi|189053116|dbj|BAG34738.1| unnamed protein product [Homo sapiens]>gi|351697547|gb|EHB00466.1| 60S ribosomal protein L21 [Heterocephalus glaber]>gi|355703111|gb|EHH29602.1| 60S ribosomal protein L21 [Macaca mulatta]>gi|355754587|gb|EHH58488.1| 60S ribosomal protein L21 [Macaca fascicularis]>gi|649102907|gb|AIC49616.1| RPL21, partial [synthetic construct]>gi|676279355|gb|KFO33328.1| 60S ribosomal protein L21 [Fukomys damarensis]>gi|1096939|prf||2113200B ribosomal protein L21 675768130 XM_003822199.2 550 0 PREDICTED: Pan paniscus 60S ribosomal protein L21 (LOC100996121), mRNA K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 P46778 849 5.2e-90 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 PF01157 Ribosomal protein L21e GO:0006412//GO:0000184//GO:0006614//GO:0006414//GO:0019083//GO:0042254//GO:0006413//GO:0006415 translation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//SRP-dependent cotranslational protein targeting to membrane//translational elongation//viral transcription//ribosome biogenesis//translational initiation//translational termination GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0022625//GO:0005840//GO:0005622 cytosolic large ribosomal subunit//ribosome//intracellular -- -- Cluster-8309.19390 BF_2 140.68 2.43 2707 270006871 EFA03319.1 2727 1.1e-305 hypothetical protein TcasGA2_TC013262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70585 1178 1.8e-127 Dystrobrevin beta OS=Mus musculus GN=Dtnb PE=1 SV=3 PF07649//PF00569//PF06657 C1-like domain//Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57 GO:0055114 oxidation-reduction process GO:0047134//GO:0008270//GO:0008017 protein-disulfide reductase activity//zinc ion binding//microtubule binding GO:0045298 tubulin complex KOG4301 Beta-dystrobrevin Cluster-8309.19392 BF_2 33.21 0.43 3525 642923986 XP_008193958.1 1893 7.1e-209 PREDICTED: dystrobrevin beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60941 957 1.0e-101 Dystrobrevin beta OS=Homo sapiens GN=DTNB PE=1 SV=1 PF00569//PF06657//PF07649 Zinc finger, ZZ type//Centrosome microtubule-binding domain of Cep57//C1-like domain GO:0055114 oxidation-reduction process GO:0047134//GO:0008017//GO:0008270 protein-disulfide reductase activity//microtubule binding//zinc ion binding GO:0045298 tubulin complex -- -- Cluster-8309.194 BF_2 11.00 0.34 1631 270003105 EEZ99552.1 218 5.6e-15 hypothetical protein TcasGA2_TC000134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF07496//PF00130 PHD-finger//CW-type Zinc Finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.19400 BF_2 1460.50 49.72 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19401 BF_2 508.00 28.80 1025 732554603 AIZ72682.1 401 2.1e-36 c-type lysozyme 4 [Harmonia axyridis] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 P37160 266 3.9e-22 Lysozyme S OS=Drosophila melanogaster GN=LysS PE=2 SV=2 PF08030 Ferric reductase NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19404 BF_2 6.00 0.34 1034 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02140 Galactose binding lectin domain -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.19406 BF_2 2.00 0.47 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19407 BF_2 685.63 8.48 3671 270004569 EFA01017.1 1392 9.2e-151 hypothetical protein TcasGA2_TC003931 [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 7.2e-34 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19408 BF_2 5.00 0.35 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19412 BF_2 259.71 7.18 1801 642931897 XP_008196773.1 465 1.4e-43 PREDICTED: SUZ domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GR00 200 3.1e-14 SUZ domain-containing protein 1 OS=Xenopus laevis GN=szrd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19416 BF_2 53.82 0.56 4341 189235365 XP_967323.2 1414 3.1e-153 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270004239|gb|EFA00687.1| hypothetical protein TcasGA2_TC003564 [Tribolium castaneum] 815793565 XM_012361984.1 64 5.21968e-22 PREDICTED: Linepithema humile uncharacterized LOC105669183 (LOC105669183), mRNA -- -- -- -- Q9VCA2 377 2.2e-34 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.19417 BF_2 8.00 0.92 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19421 BF_2 323.00 14.87 1196 546676950 ERL87874.1 228 2.8e-16 hypothetical protein D910_05262 [Dendroctonus ponderosae] -- -- -- -- -- K02919 RP-L36, MRPL36, rpmJ large subunit ribosomal protein L36 http://www.genome.jp/dbget-bin/www_bget?ko:K02919 -- -- -- -- PF00444//PF06374 Ribosomal protein L36//NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006120//GO:0006412//GO:0006814//GO:0006744//GO:0015992//GO:0042254 mitochondrial electron transport, NADH to ubiquinone//translation//sodium ion transport//ubiquinone biosynthetic process//proton transport//ribosome biogenesis GO:0003735//GO:0008137 structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity GO:0005743//GO:0005840//GO:0005622 mitochondrial inner membrane//ribosome//intracellular -- -- Cluster-8309.19423 BF_2 693.96 9.49 3345 91094203 XP_971608.1 2074 7.0e-230 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.22677e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 1420 2.0e-155 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.19425 BF_2 2.00 0.44 476 190589906 ACE79213.1 686 8.8e-70 heat shock protein 70 [Scylla paramamosain]>gi|418206087|gb|AFX62572.1| heat shock protein 70 [Scylla paramamosain]>gi|418206089|gb|AFX62573.1| heat shock protein 70 [Scylla paramamosain]>gi|418206091|gb|AFX62574.1| heat shock protein 70 [Scylla paramamosain]>gi|418206093|gb|AFX62575.1| heat shock protein 70 [Scylla paramamosain]>gi|418206095|gb|AFX62576.1| heat shock protein 70 [Scylla paramamosain]>gi|418206097|gb|AFX62577.1| heat shock protein 70 [Scylla paramamosain]>gi|418206099|gb|AFX62578.1| heat shock protein 70 [Scylla paramamosain] 190589905 EU754021.1 476 0 Scylla paramamosain heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P08108 608 4.0e-62 Heat shock cognate 70 kDa protein OS=Oncorhynchus mykiss GN=hsc71 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.19426 BF_2 349.44 6.82 2429 546673262 ERL84900.1 1192 9.5e-128 hypothetical protein D910_02323 [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 824 1.8e-86 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF09238//PF00287 Interleukin-4 receptor alpha chain, N-terminal//Sodium / potassium ATPase beta chain GO:0006813//GO:0007165//GO:0006814//GO:0002532 potassium ion transport//signal transduction//sodium ion transport//production of molecular mediator involved in inflammatory response GO:0004896 cytokine receptor activity GO:0016021//GO:0005890 integral component of membrane//sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.19427 BF_2 71.00 4.14 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19428 BF_2 16.16 1.56 720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19432 BF_2 12.84 1.49 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19433 BF_2 97.37 3.94 1321 642910457 XP_008190746.1 1296 4.5e-140 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum]>gi|642910459|ref|XP_008190747.1| PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum] 347969268 XM_003436347.1 39 1.2316e-08 Anopheles gambiae str. PEST AGAP003108-PB (AgaP_AGAP003108) mRNA, complete cds K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P22607 903 6.9e-96 Fibroblast growth factor receptor 3 OS=Homo sapiens GN=FGFR3 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.19435 BF_2 192.83 2.88 3087 270015126 EFA11574.1 2461 8.6e-275 heartless [Tribolium castaneum] 462340826 APGK01036266.1 85 7.8393e-34 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1459 5.4e-160 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF13895//PF00069//PF07714 Immunoglobulin domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- -- -- Cluster-8309.19437 BF_2 33.62 1.37 1313 270015126 EFA11574.1 1296 4.5e-140 heartless [Tribolium castaneum] 347969268 XM_003436347.1 39 1.22394e-08 Anopheles gambiae str. PEST AGAP003108-PB (AgaP_AGAP003108) mRNA, complete cds K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P22607 903 6.9e-96 Fibroblast growth factor receptor 3 OS=Homo sapiens GN=FGFR3 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.19439 BF_2 759.64 7.95 4284 91083631 XP_970382.1 4149 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.7017e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 P11024 3168 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Bos taurus GN=NNT PE=1 SV=3 PF00107//PF07074//PF00005//PF02233//PF02826//PF03188//PF01752//PF00205 Zinc-binding dehydrogenase//Translocon-associated protein, gamma subunit (TRAP-gamma)//ABC transporter//NAD(P) transhydrogenase beta subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Collagenase//Thiamine pyrophosphate enzyme, central domain GO:0006613//GO:0046497//GO:0055114//GO:0015992//GO:0006769//GO:0006508 cotranslational protein targeting to membrane//nicotinate nucleotide metabolic process//oxidation-reduction process//proton transport//nicotinamide metabolic process//proteolysis GO:0005524//GO:0008750//GO:0016887//GO:0008270//GO:0004252//GO:0050661//GO:0051287//GO:0000287//GO:0030976 ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//ATPase activity//zinc ion binding//serine-type endopeptidase activity//NADP binding//NAD binding//magnesium ion binding//thiamine pyrophosphate binding GO:0016021//GO:0030176//GO:0005784//GO:0005576 integral component of membrane//integral component of endoplasmic reticulum membrane//Sec61 translocon complex//extracellular region -- -- Cluster-8309.19440 BF_2 22.53 0.44 2444 546681066 ERL91222.1 2053 1.4e-227 hypothetical protein D910_08559 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P07861 812 4.6e-85 Neprilysin OS=Rattus norvegicus GN=Mme PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.19443 BF_2 285.55 3.43 3770 91095023 XP_970355.1 729 7.2e-74 PREDICTED: inhibin beta chain [Tribolium castaneum]>gi|270015436|gb|EFA11884.1| dawdle [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 O61643 219 4.1e-16 Inhibin beta chain OS=Drosophila melanogaster GN=Actbeta PE=2 SV=2 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity GO:0005576 extracellular region -- -- Cluster-8309.19444 BF_2 94.00 51.49 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19446 BF_2 55.84 1.10 2420 642933276 XP_008197354.1 1014 4.1e-107 PREDICTED: cell wall protein RBR3 isoform X1 [Tribolium castaneum] 817211936 XM_012426709.1 59 1.74093e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.1e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19447 BF_2 36.00 0.88 1992 642928233 XP_008195498.1 500 1.4e-47 PREDICTED: uncharacterized protein LOC103313601 [Tribolium castaneum]>gi|270010319|gb|EFA06767.1| hypothetical protein TcasGA2_TC009701 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01737 YCF9 GO:0015979//GO:0042549 photosynthesis//photosystem II stabilization -- -- GO:0009523//GO:0009539 photosystem II//photosystem II reaction center -- -- Cluster-8309.19448 BF_2 2.00 2.25 312 270015672 EFA12120.1 221 4.7e-16 hypothetical protein TcasGA2_TC002266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 203 2.4e-15 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19450 BF_2 7.06 0.55 825 189236834 XP_001812569.1 681 5.8e-69 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270005053|gb|EFA01501.1| hypothetical protein TcasGA2_TC007057 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF16622//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.19454 BF_2 469.00 30.33 934 268370065 NP_001161226.1 701 3.1e-71 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b [Tribolium castaneum]>gi|270014564|gb|EFA11012.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC004599 [Tribolium castaneum] 686803186 LM223515.1 42 1.85318e-10 Strongylus vulgaris genome assembly S_vulgaris_Kentucky ,scaffold SVUK_scaffold0011471 K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q91V37 494 1.3e-48 V-type proton ATPase 21 kDa proteolipid subunit OS=Mus musculus GN=Atp6v0b PE=1 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.19456 BF_2 37.08 0.57 3031 672273128 KFG45225.1 147 1.8e-06 IgA-specific metalloendopeptidase [Toxoplasma gondii GAB2-2007-GAL-DOM2] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03502 Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279 cell outer membrane -- -- Cluster-8309.19463 BF_2 55.87 3.70 919 642936711 XP_008200418.1 1111 8.8e-119 PREDICTED: eukaryotic initiation factor 4E isoform X1 [Tribolium castaneum] 642936710 XM_008202196.1 172 9.86319e-83 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4E (eIF-4E), transcript variant X1, mRNA K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 Q8BMB3 606 1.3e-61 Eukaryotic translation initiation factor 4E type 2 OS=Mus musculus GN=Eif4e2 PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.19466 BF_2 83.33 1.88 2145 642927675 XP_008195360.1 1255 4.2e-135 PREDICTED: NAD kinase 2, mitochondrial, partial [Tribolium castaneum] -- -- -- -- -- K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 Q1HCL7 635 1.3e-64 NAD kinase 2, mitochondrial OS=Rattus norvegicus GN=Nadk2 PE=2 SV=1 PF01513//PF00781//PF03575 ATP-NAD kinase//Diacylglycerol kinase catalytic domain//Peptidase family S51 GO:0006508//GO:0006741//GO:0006769//GO:0008152//GO:0046497 proteolysis//NADP biosynthetic process//nicotinamide metabolic process//metabolic process//nicotinate nucleotide metabolic process GO:0016301//GO:0008236//GO:0003951 kinase activity//serine-type peptidase activity//NAD+ kinase activity -- -- KOG4180 Predicted kinase Cluster-8309.19469 BF_2 48.00 0.87 2584 478259248 ENN79150.1 608 5.3e-60 hypothetical protein YQE_04336, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04728//PF14817//PF06009//PF07989//PF10392//PF04513 Lipoprotein leucine-zipper//HAUS augmin-like complex subunit 5//Laminin Domain II//Centrosomin N-terminal motif 1//Golgi transport complex subunit 5//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0051225//GO:0006891//GO:0007155 spindle assembly//intra-Golgi vesicle-mediated transport//cell adhesion GO:0005198 structural molecule activity GO:0019031//GO:0005815//GO:0019028//GO:0019867//GO:0070652//GO:0017119 viral envelope//microtubule organizing center//viral capsid//outer membrane//HAUS complex//Golgi transport complex -- -- Cluster-8309.19472 BF_2 4.00 0.32 810 -- -- -- -- -- 462289926 APGK01054630.1 45 3.43437e-12 Dendroctonus ponderosae Seq01054640, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19473 BF_2 41.40 0.51 3716 642936336 XP_008198400.1 2005 7.8e-222 PREDICTED: Werner syndrome ATP-dependent helicase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10900 WRN, RECQL2 werner syndrome ATP-dependent helicase http://www.genome.jp/dbget-bin/www_bget?ko:K10900 Q14191 1252 6.6e-136 Werner syndrome ATP-dependent helicase OS=Homo sapiens GN=WRN PE=1 SV=2 PF00570//PF00196//PF09382//PF00270//PF04851//PF06480 HRDC domain//Bacterial regulatory proteins, luxR family//RQC domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//FtsH Extracellular GO:0006281//GO:0006355//GO:0006260 DNA repair//regulation of transcription, DNA-templated//DNA replication GO:0005524//GO:0004222//GO:0003677//GO:0016787//GO:0043140//GO:0008270//GO:0003676 ATP binding//metalloendopeptidase activity//DNA binding//hydrolase activity//ATP-dependent 3'-5' DNA helicase activity//zinc ion binding//nucleic acid binding GO:0016021//GO:0005657//GO:0005622 integral component of membrane//replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.19475 BF_2 10.00 1.10 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19478 BF_2 104.00 5.14 1133 170321839 BAG14264.1 566 1.7e-55 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q26422 223 4.2e-17 Limulus clotting factor C OS=Carcinoscorpius rotundicauda PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.19480 BF_2 121.50 1.97 2873 91086355 XP_974424.1 1157 1.3e-123 PREDICTED: transcription factor TFIIIB component B'' homolog [Tribolium castaneum]>gi|270010281|gb|EFA06729.1| hypothetical protein TcasGA2_TC009660 [Tribolium castaneum] -- -- -- -- -- K15198 BDP1, TFC5 transcription factor TFIIIB component B'' http://www.genome.jp/dbget-bin/www_bget?ko:K15198 Q571C7 315 2.3e-27 Transcription factor TFIIIB component B'' homolog OS=Mus musculus GN=Bdp1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2009 Transcription initiation factor TFIIIB, Bdp1 subunit Cluster-8309.19481 BF_2 184.20 1.65 4956 332372780 AEE61532.1 1204 7.9e-129 unknown [Dendroctonus ponderosae] 564241437 XM_006277474.1 68 3.56491e-24 PREDICTED: Alligator mississippiensis sideroflexin-1-like (LOC102569899), mRNA -- -- -- -- Q5E9M8 908 6.8e-96 Sideroflexin-1 OS=Bos taurus GN=SFXN1 PE=2 SV=3 PF03820//PF03600 Tricarboxylate carrier//Citrate transporter GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0015075 ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3767 Sideroflexin Cluster-8309.19482 BF_2 27.00 0.79 1724 270005985 EFA02433.1 283 1.7e-22 hypothetical protein TcasGA2_TC008120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19483 BF_2 2.23 0.75 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19488 BF_2 647.95 15.32 2056 478254642 ENN74884.1 1051 1.8e-111 hypothetical protein YQE_08549, partial [Dendroctonus ponderosae]>gi|546679235|gb|ERL89729.1| hypothetical protein D910_07090 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0N0X6 253 2.5e-20 Leucine-rich repeat neuronal protein 1 OS=Bos taurus GN=LRRN1 PE=3 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.19489 BF_2 10.00 2.22 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19490 BF_2 6.00 3.77 349 741893281 XP_005195212.2 481 3.8e-46 PREDICTED: tubulin alpha-3 chain isoform X1 [Bos taurus] 32987769 AK102560.1 349 0 Oryza sativa Japonica Group cDNA clone:J033097H22, full insert sequence >gnl|BL_ORD_ID|7101460 Oryza sativa Japonica Group TID1 mRNA for alpha-tubulin, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q53M52 491 1.1e-48 Tubulin alpha-2 chain OS=Oryza sativa subsp. japonica GN=TUBA PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.19494 BF_2 95.90 1.30 3381 270007992 EFA04440.1 701 1.1e-70 hypothetical protein TcasGA2_TC014742 [Tribolium castaneum] -- -- -- -- -- K18754 LIN28 protein lin-28 http://www.genome.jp/dbget-bin/www_bget?ko:K18754 Q9VRN5 534 1.1e-52 Protein lin-28 homolog OS=Drosophila melanogaster GN=lin-28 PE=2 SV=2 PF08024//PF00098//PF00313 Ant antimicrobial peptide//Zinc knuckle//'Cold-shock' DNA-binding domain GO:0006355//GO:0019836 regulation of transcription, DNA-templated//hemolysis by symbiont of host erythrocytes GO:0008270//GO:0003676//GO:0003677 zinc ion binding//nucleic acid binding//DNA binding GO:0005576 extracellular region KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.19495 BF_2 248.00 8189.26 206 -- -- -- -- -- 527047441 HG323740.1 195 3.17882e-96 TPA: Oryza sativa Japonica Group SRP RNA for signal recognition particle RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19496 BF_2 224.95 3.71 2822 642936911 XP_008194442.1 3085 0.0e+00 PREDICTED: PHD finger protein 14 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H9 1117 2.3e-120 PHD finger protein 14 OS=Mus musculus GN=Phf14 PE=1 SV=1 PF06156//PF00628//PF02059//PF01017//PF00130 Protein of unknown function (DUF972)//PHD-finger//Interleukin-3//STAT protein, all-alpha domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006955//GO:0006260//GO:0006355//GO:0035556//GO:0007165//GO:0040007//GO:0008283 immune response//DNA replication//regulation of transcription, DNA-templated//intracellular signal transduction//signal transduction//growth//cell proliferation GO:0004871//GO:0003700//GO:0008083//GO:0005135//GO:0005515 signal transducer activity//transcription factor activity, sequence-specific DNA binding//growth factor activity//interleukin-3 receptor binding//protein binding GO:0005894//GO:0005576//GO:0005667 interleukin-3 receptor complex//extracellular region//transcription factor complex KOG0957 PHD finger protein Cluster-8309.195 BF_2 22.93 0.36 2934 642932504 XP_008197141.1 675 1.0e-67 PREDICTED: kielin/chordin-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12297//PF00093 Ellis van Creveld protein 2 like protein//von Willebrand factor type C domain GO:0007224 smoothened signaling pathway GO:0005515 protein binding -- -- -- -- Cluster-8309.19500 BF_2 1.00 0.55 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19503 BF_2 61.01 3.22 1080 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19505 BF_2 33.01 1.18 1460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19511 BF_2 516.67 6.96 3391 478254666 ENN74907.1 2515 5.2e-281 hypothetical protein YQE_08485, partial [Dendroctonus ponderosae] -- -- -- -- -- K18085 MTMR10_11_12 myotubularin-related protein 10/11/12 http://www.genome.jp/dbget-bin/www_bget?ko:K18085 Q6NU08 902 2.3e-95 Myotubularin-related protein 10-B OS=Xenopus laevis GN=mtmr10-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.19512 BF_2 80.04 1.10 3332 642924705 XP_008194405.1 3519 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 isoform X1 [Tribolium castaneum]>gi|270007980|gb|EFA04428.1| hypothetical protein TcasGA2_TC014728 [Tribolium castaneum] 642924706 XM_008196184.1 77 2.37136e-29 PREDICTED: Tribolium castaneum inactive dipeptidyl peptidase 10 (LOC663947), transcript variant X2, mRNA -- -- -- -- Q5IS50 990 1.4e-105 Dipeptidyl aminopeptidase-like protein 6 OS=Pan troglodytes GN=DPP6 PE=2 SV=1 PF00930//PF00326 Dipeptidyl peptidase IV (DPP IV) N-terminal region//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity GO:0016020 membrane KOG2100 Dipeptidyl aminopeptidase Cluster-8309.19516 BF_2 240.00 9.57 1336 478257348 ENN77508.1 731 1.5e-74 hypothetical protein YQE_06034, partial [Dendroctonus ponderosae] -- -- -- -- -- K14306 NUP62, NSP1 nuclear pore complex protein Nup62 http://www.genome.jp/dbget-bin/www_bget?ko:K14306 P37198 451 1.8e-43 Nuclear pore glycoprotein p62 OS=Homo sapiens GN=NUP62 PE=1 SV=3 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- KOG2196 Nuclear porin Cluster-8309.19518 BF_2 197.00 8.04 1312 642916924 XP_971551.3 1515 1.8e-165 PREDICTED: diphthamide biosynthesis protein 1 [Tribolium castaneum]>gi|270003030|gb|EEZ99477.1| hypothetical protein TcasGA2_TC000051 [Tribolium castaneum] 815770825 XM_012380143.1 72 5.53124e-27 PREDICTED: Linepithema humile diphthamide biosynthesis protein 1 (LOC105679855), mRNA K07561 dph2, DPH1 2-(3-amino-3-carboxypropyl)histidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K07561 Q6GPQ5 1224 4.1e-133 Diphthamide biosynthesis protein 1 OS=Xenopus laevis GN=dph1 PE=2 SV=2 -- -- GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine -- -- GO:0005737 cytoplasm KOG2648 Diphthamide biosynthesis protein Cluster-8309.19519 BF_2 130.00 6.87 1079 478256835 ENN77010.1 959 4.4e-101 hypothetical protein YQE_06504, partial [Dendroctonus ponderosae] -- -- -- -- -- K06997 yggS, PROSC PLP dependent protein http://www.genome.jp/dbget-bin/www_bget?ko:K06997 O94903 715 3.6e-74 Proline synthase co-transcribed bacterial homolog protein OS=Homo sapiens GN=PROSC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3157 Proline synthetase co-transcribed protein Cluster-8309.19520 BF_2 3.00 38.50 255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19521 BF_2 36.55 0.47 3564 91094511 XP_971832.1 460 1.1e-42 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.59272e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q8VHV7 277 7.2e-23 Heterogeneous nuclear ribonucleoprotein H OS=Rattus norvegicus GN=Hnrnph1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.19523 BF_2 150.00 4.58 1658 91077876 XP_972781.1 1089 5.7e-116 PREDICTED: mediator of RNA polymerase II transcription subunit 4 [Tribolium castaneum] -- -- -- -- -- K15146 MED4 mediator of RNA polymerase II transcription subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15146 Q7QH62 785 4.2e-82 Mediator of RNA polymerase II transcription subunit 4 OS=Anopheles gambiae GN=MED4 PE=3 SV=3 PF04888//PF03255//PF10018//PF04111 Secretion system effector C (SseC) like family//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Vitamin-D-receptor interacting Mediator subunit 4//Autophagy protein Apg6 GO:0006357//GO:0006090//GO:0009405//GO:0006633//GO:0006914 regulation of transcription from RNA polymerase II promoter//pyruvate metabolic process//pathogenesis//fatty acid biosynthetic process//autophagy GO:0003989//GO:0001104 acetyl-CoA carboxylase activity//RNA polymerase II transcription cofactor activity GO:0009317//GO:0016592 acetyl-CoA carboxylase complex//mediator complex KOG4552 Vitamin-D-receptor interacting protein complex component Cluster-8309.19528 BF_2 2.00 0.49 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19530 BF_2 176.00 4.72 1846 478260093 ENN79878.1 1495 5.3e-163 hypothetical protein YQE_03697, partial [Dendroctonus ponderosae]>gi|546676554|gb|ERL87543.1| hypothetical protein D910_04934, partial [Dendroctonus ponderosae] -- -- -- -- -- K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 O61303 1302 5.2e-142 Opsin, ultraviolet-sensitive OS=Apis mellifera GN=UVOP PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.19531 BF_2 420.81 3.98 4715 546686185 ERL95565.1 341 8.8e-29 hypothetical protein D910_12826 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19535 BF_2 11.00 0.95 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19536 BF_2 263.06 40.62 558 478258777 ENN78800.1 325 7.5e-28 hypothetical protein YQE_04737, partial [Dendroctonus ponderosae]>gi|546678780|gb|ERL89332.1| hypothetical protein D910_06704 [Dendroctonus ponderosae] 42764849 AY439820.1 76 1.35679e-29 Armigeres subalbatus ASAP ID: 40029 barrier-to-autointegration factor mRNA sequence -- -- -- -- Q9R1T1 272 4.3e-23 Barrier-to-autointegration factor OS=Rattus norvegicus GN=Banf1 PE=1 SV=1 PF02961 Barrier to autointegration factor -- -- GO:0003677 DNA binding -- -- KOG4233 DNA-bridging protein BAF Cluster-8309.19537 BF_2 24.19 0.98 1321 642924337 XP_008194253.1 1524 1.6e-166 PREDICTED: LOW QUALITY PROTEIN: protein RCC2 homolog [Tribolium castaneum] 462382197 APGK01021748.1 134 1.90661e-61 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 931 3.9e-99 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19542 BF_2 74.23 10.86 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19544 BF_2 91.06 2.48 1821 270015237 EFA11685.1 1452 5.1e-158 hypothetical protein TcasGA2_TC008549 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS86 887 6.8e-94 LanC-like protein 2 OS=Homo sapiens GN=LANCL2 PE=1 SV=1 PF04223 Citrate lyase, alpha subunit (CitF) GO:0006084//GO:0006099 acetyl-CoA metabolic process//tricarboxylic acid cycle GO:0008814 citrate CoA-transferase activity GO:0009346//GO:0005737 citrate lyase complex//cytoplasm KOG2787 Lanthionine synthetase C-like protein 1 Cluster-8309.19547 BF_2 45.42 0.51 4011 642938488 XP_008197979.1 2563 1.7e-286 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X3 [Tribolium castaneum] 805759873 XM_012297744.1 247 8.99225e-124 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.6e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.19548 BF_2 2.00 0.78 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19549 BF_2 179.08 2.39 3417 546670638 ERL83322.1 610 4.1e-60 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19551 BF_2 5.00 0.56 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19555 BF_2 127.98 1.78 3298 270004708 EFA01156.1 460 9.8e-43 hypothetical protein TcasGA2_TC010381 [Tribolium castaneum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q566L7 195 2.2e-13 Protein LSM14 homolog B OS=Xenopus tropicalis GN=lsm14b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.19557 BF_2 501.31 3.47 6333 835482914 AKM70276.1 219 1.7e-14 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19558 BF_2 58.91 0.61 4314 357625687 EHJ76049.1 1321 1.9e-142 dimethyladenosine transferase [Danaus plexippus] 505801989 XM_004608470.1 131 2.94996e-59 PREDICTED: Sorex araneus DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) (DIMT1), mRNA K14191 DIM1 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14191 Q9VAQ5 1179 2.2e-127 Probable dimethyladenosine transferase OS=Drosophila melanogaster GN=CG11837 PE=2 SV=1 PF09445//PF05958//PF01135//PF05175//PF02390//PF08241//PF08123//PF01209//PF05401 RNA cap guanine-N2 methyltransferase//tRNA (Uracil-5-)-methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain//Histone methylation protein DOT1//ubiE/COQ5 methyltransferase family//Nodulation protein S (NodS) GO:0006554//GO:0008033//GO:0006396//GO:0009312//GO:0006464//GO:0006479//GO:0009451//GO:0009877//GO:0046500//GO:0006400//GO:0001510//GO:0009452//GO:0008152 lysine catabolic process//tRNA processing//RNA processing//oligosaccharide biosynthetic process//cellular protein modification process//protein methylation//RNA modification//nodulation//S-adenosylmethionine metabolic process//tRNA modification//RNA methylation//7-methylguanosine RNA capping//metabolic process GO:0008168//GO:0004719//GO:0008176//GO:0008757//GO:0018024//GO:0008173 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//histone-lysine N-methyltransferase activity//RNA methyltransferase activity -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.19563 BF_2 1.82 0.65 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19569 BF_2 8.00 7.94 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19570 BF_2 47.97 0.31 6757 91076790 XP_974060.1 950 3.0e-99 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88879 361 2.5e-32 Apoptotic protease-activating factor 1 OS=Mus musculus GN=Apaf1 PE=1 SV=3 PF00619//PF07569//PF00931//PF00400//PF02038//PF01637 Caspase recruitment domain//TUP1-like enhancer of split//NB-ARC domain//WD domain, G-beta repeat//ATP1G1/PLM/MAT8 family//Archaeal ATPase GO:0006811//GO:0042981//GO:0006355 ion transport//regulation of apoptotic process//regulation of transcription, DNA-templated GO:0005515//GO:0043531//GO:0005524//GO:0005216 protein binding//ADP binding//ATP binding//ion channel activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.19576 BF_2 8.00 3.67 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02150//PF00096//PF13465 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.19578 BF_2 260.00 6.49 1963 546683129 ERL92980.1 155 1.4e-07 hypothetical protein D910_10283 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19579 BF_2 7.00 0.53 835 642923181 XP_008193644.1 584 1.0e-57 PREDICTED: protein Wnt-11b-1-like [Tribolium castaneum] -- -- -- -- -- K01384 WNT11 wingless-type MMTV integration site family, member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K01384 Q66II0 230 4.8e-18 Protein Wnt-11b-1 OS=Xenopus tropicalis GN=wnt11b-1 PE=2 SV=1 PF00110//PF00981 wnt family//Rotavirus RNA-binding Protein 53 (NS53) GO:0007165//GO:0016055//GO:0007275 signal transduction//Wnt signaling pathway//multicellular organismal development GO:0003723//GO:0005102 RNA binding//receptor binding GO:0005576 extracellular region KOG3913 Wnt family of developmental regulators Cluster-8309.19580 BF_2 378.08 18.99 1120 642922922 XP_971943.2 772 2.2e-79 PREDICTED: coiled-coil domain-containing protein 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T312 581 1.3e-58 Coiled-coil domain-containing protein 25 OS=Danio rerio GN=ccdc25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3272 Predicted coiled-coil protein Cluster-8309.19585 BF_2 15.00 2.36 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19586 BF_2 173.11 1.06 7149 642917646 XP_008193467.1 1224 5.4e-131 PREDICTED: activating transcription factor 7-interacting protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6VMQ6 269 1.2e-21 Activating transcription factor 7-interacting protein 1 OS=Homo sapiens GN=ATF7IP PE=1 SV=3 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19588 BF_2 35.54 0.46 3541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01079 Hint module GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-8309.19589 BF_2 5.61 0.90 549 478257268 ENN77431.1 448 4.0e-42 hypothetical protein YQE_06255, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 279 6.5e-24 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.19591 BF_2 10.02 0.53 1081 91076690 XP_971724.1 310 7.9e-26 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 58 2.74961e-19 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 A2APY7 244 1.5e-19 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Mus musculus GN=Ndufaf5 PE=2 SV=1 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- KOG2940 Predicted methyltransferase Cluster-8309.19593 BF_2 4.00 0.81 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19596 BF_2 301.98 11.16 1419 642932585 XP_008196912.1 445 2.3e-41 PREDICTED: S-adenosylmethionine decarboxylase proenzyme isoform X1 [Tribolium castaneum] -- -- -- -- -- K01611 speD, AMD1 S-adenosylmethionine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01611 P91931 262 1.6e-21 S-adenosylmethionine decarboxylase proenzyme OS=Drosophila melanogaster GN=SamDC PE=2 SV=1 PF01536 Adenosylmethionine decarboxylase GO:0006525//GO:0006597//GO:0008295//GO:0006560 arginine metabolic process//spermine biosynthetic process//spermidine biosynthetic process//proline metabolic process GO:0004014 adenosylmethionine decarboxylase activity -- -- KOG0788 S-adenosylmethionine decarboxylase Cluster-8309.19604 BF_2 60.38 1.58 1881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19605 BF_2 9.71 1.59 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19606 BF_2 11.00 0.49 1222 642918761 XP_008191572.1 333 1.9e-28 PREDICTED: FMRFamide-related neuropeptides [Tribolium castaneum]>gi|642918763|ref|XP_008191573.1| PREDICTED: FMRFamide-related neuropeptides [Tribolium castaneum]>gi|642918765|ref|XP_008191574.1| PREDICTED: FMRFamide-related neuropeptides [Tribolium castaneum]>gi|270006415|gb|EFA02863.1| FMRFamide-related [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10552 207 3.2e-15 FMRFamide-related peptides OS=Drosophila melanogaster GN=Fmrf PE=1 SV=2 PF01581 FMRFamide related peptide family GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.19607 BF_2 94.61 1.74 2563 478260221 ENN79984.1 222 3.0e-15 hypothetical protein YQE_03578, partial [Dendroctonus ponderosae]>gi|546675215|gb|ERL86451.1| hypothetical protein D910_03858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19609 BF_2 568.77 17.18 1672 546675450 ERL86638.1 628 1.6e-62 hypothetical protein D910_04045 [Dendroctonus ponderosae] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 P24485 272 1.3e-22 Leukocyte surface antigen CD53 OS=Rattus norvegicus GN=Cd53 PE=1 SV=3 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.19611 BF_2 20.00 4.70 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19615 BF_2 15.18 0.83 1049 642924004 XP_008193965.1 762 3.0e-78 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 343 4.7e-31 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400//PF03275 WD domain, G-beta repeat//UDP-galactopyranose mutase -- -- GO:0005515//GO:0008767 protein binding//UDP-galactopyranose mutase activity -- -- KOG1188 WD40 repeat protein Cluster-8309.19617 BF_2 34.20 1.88 1050 642924004 XP_008193965.1 778 4.2e-80 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBK1 337 2.3e-30 WD repeat-containing protein 89 OS=Bos taurus GN=WDR89 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1188 WD40 repeat protein Cluster-8309.19620 BF_2 293.13 6.95 2051 546678419 ERL89042.1 730 3.0e-74 hypothetical protein D910_06420 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR0 414 5.4e-39 Kelch domain-containing protein 10 OS=Mus musculus GN=Klhdc10 PE=1 SV=1 PF09187//PF00892//PF01344//PF07646 Domain of unknown function(DUF1950)//EamA-like transporter family//Kelch motif//Kelch motif GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0016021//GO:0005634 membrane//integral component of membrane//nucleus -- -- Cluster-8309.19621 BF_2 35.43 0.81 2107 478259245 ENN79147.1 612 1.5e-60 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28DE7 378 8.3e-35 Kelch domain-containing protein 10 OS=Xenopus tropicalis GN=klhdc10 PE=2 SV=2 PF07646//PF01344//PF00892//PF09187 Kelch motif//Kelch motif//EamA-like transporter family//Domain of unknown function(DUF1950) GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0016021//GO:0005634 membrane//integral component of membrane//nucleus -- -- Cluster-8309.19622 BF_2 34.23 0.84 1990 478259245 ENN79147.1 405 1.4e-36 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0IIC2 236 2.3e-18 Kelch domain-containing protein 10 OS=Bos taurus GN=KLHDC10 PE=2 SV=1 PF07646//PF01344//PF09187//PF00892 Kelch motif//Kelch motif//Domain of unknown function(DUF1950)//EamA-like transporter family GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0005634//GO:0016021 membrane//nucleus//integral component of membrane -- -- Cluster-8309.19629 BF_2 25.64 0.91 1465 826409641 XP_012534005.1 166 5.4e-09 PREDICTED: uncharacterized protein LOC105835358, partial [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19633 BF_2 2043.54 27.88 3353 300394168 ADK11710.1 1721 6.0e-189 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P15684 1089 4.7e-117 Aminopeptidase N OS=Rattus norvegicus GN=Anpep PE=1 SV=2 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.19637 BF_2 50.00 1.78 1460 91082005 XP_969623.1 1498 1.9e-163 PREDICTED: general transcription factor IIE subunit 1 [Tribolium castaneum]>gi|270007311|gb|EFA03759.1| hypothetical protein TcasGA2_TC013870 [Tribolium castaneum] 665785740 XM_008550591.1 225 5.47287e-112 PREDICTED: Microplitis demolitor general transcription factor IIE subunit 1 (LOC103572130), transcript variant X2, mRNA K03136 TFIIE1, GTF2E1, TFA1, tfe transcription initiation factor TFIIE subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03136 A6QLI8 784 4.8e-82 General transcription factor IIE subunit 1 OS=Bos taurus GN=GTF2E1 PE=2 SV=1 PF13912//PF13465//PF00318 C2H2-type zinc finger//Zinc-finger double domain//Ribosomal protein S2 GO:0006367//GO:0042254//GO:0006412 transcription initiation from RNA polymerase II promoter//ribosome biogenesis//translation GO:0043565//GO:0003735//GO:0046872 sequence-specific DNA binding//structural constituent of ribosome//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular KOG2593 Transcription initiation factor IIE, alpha subunit Cluster-8309.19638 BF_2 75.76 0.65 5132 642937669 XP_008198894.1 1681 4.0e-184 PREDICTED: uncharacterized protein LOC103314480 [Tribolium castaneum]>gi|270001142|gb|EEZ97589.1| hypothetical protein TcasGA2_TC011452 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02119 Flagellar P-ring protein GO:0071973 bacterial-type flagellum-dependent cell motility GO:0005198//GO:0016772 structural molecule activity//transferase activity, transferring phosphorus-containing groups GO:0009428//GO:0030288 bacterial-type flagellum basal body, distal rod, P ring//outer membrane-bounded periplasmic space -- -- Cluster-8309.19639 BF_2 3.00 0.61 493 391338350 XP_003743522.1 664 3.2e-67 PREDICTED: glutamate receptor 1-like [Metaseiulus occidentalis] 270298179 FJ882065.1 69 9.27583e-26 Pteromalus puparum arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 O96507 584 2.5e-59 Arginine kinase OS=Trypanosoma cruzi PE=1 SV=1 PF00217//PF02807 ATP:guanido phosphotransferase, C-terminal catalytic domain//ATP:guanido phosphotransferase, N-terminal domain -- -- GO:0016772//GO:0016301 transferase activity, transferring phosphorus-containing groups//kinase activity -- -- KOG3581 Creatine kinases Cluster-8309.19640 BF_2 27.00 2.78 693 227955307 ACP43443.1 637 6.1e-64 arginine kinase [Scylla olivacea] 388267610 JQ031765.1 690 0 Scylla paramamosain arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 Q9GYX1 636 3.3e-65 Arginine kinase OS=Pachygrapsus marmoratus PE=2 SV=1 PF00217 ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.19642 BF_2 43.00 1.37 1600 227955307 ACP43443.1 1761 6.6e-194 arginine kinase [Scylla olivacea] 388267610 JQ031765.1 862 0 Scylla paramamosain arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 Q9NH49 1750 5.1e-194 Arginine kinase OS=Callinectes sapidus PE=2 SV=1 PF02807//PF00217 ATP:guanido phosphotransferase, N-terminal domain//ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016772//GO:0016301 transferase activity, transferring phosphorus-containing groups//kinase activity -- -- KOG3581 Creatine kinases Cluster-8309.19644 BF_2 67.48 3.00 1229 642931541 XP_008196629.1 946 1.6e-99 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q09499 510 2.4e-50 Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=1 SV=2 -- -- GO:0006397//GO:0006468//GO:0009069//GO:0016310//GO:0051252 mRNA processing//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//regulation of RNA metabolic process GO:0005524//GO:0016891//GO:0004674 ATP binding//endoribonuclease activity, producing 5'-phosphomonoesters//protein serine/threonine kinase activity -- -- KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.19645 BF_2 71.42 1.64 2104 642931541 XP_008196629.1 1804 8.9e-199 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 O75460 1229 1.7e-133 Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2 PF06479//PF00804//PF06293//PF00069//PF07714 Ribonuclease 2-5A//Syntaxin//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0044260//GO:0006397//GO:0044238//GO:0051252 protein phosphorylation//cellular macromolecule metabolic process//mRNA processing//primary metabolic process//regulation of RNA metabolic process GO:0004540//GO:0005524//GO:0004672//GO:0016773 ribonuclease activity//ATP binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.19646 BF_2 19.76 0.52 1888 642934029 XP_008197611.1 328 1.1e-27 PREDICTED: uncharacterized protein LOC662748 isoform X1 [Tribolium castaneum]>gi|642934031|ref|XP_008197613.1| PREDICTED: uncharacterized protein LOC662748 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19647 BF_2 4.00 0.72 520 546673982 ERL85486.1 184 1.6e-11 hypothetical protein D910_02905 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19650 BF_2 481.00 15.61 1576 270011477 EFA07925.1 1108 3.4e-118 hypothetical protein TcasGA2_TC005503 [Tribolium castaneum] 817212223 XM_012426867.1 34 8.88214e-06 PREDICTED: Orussus abietinus pancreatic triacylglycerol lipase-like (LOC105700724), mRNA -- -- -- -- P54318 350 1.1e-31 Pancreatic lipase-related protein 2 OS=Rattus norvegicus GN=Pnliprp2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19654 BF_2 170.41 1.67 4552 91087139 XP_975272.1 1440 3.1e-156 PREDICTED: zinc finger protein PLAG1 [Tribolium castaneum]>gi|270009590|gb|EFA06038.1| hypothetical protein TcasGA2_TC008868 [Tribolium castaneum] 642929548 XM_970179.2 86 3.22621e-34 PREDICTED: Tribolium castaneum zinc finger protein PLAG1 (LOC664166), mRNA K19484 PLAG1 zinc finger protein PLAG1 http://www.genome.jp/dbget-bin/www_bget?ko:K19484 A6NDX5 384 3.6e-35 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF16622//PF07975//PF00130//PF13465//PF00096 zinc-finger C2H2-type//TFIIH C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556//GO:0006281 intracellular signal transduction//DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.19655 BF_2 422.00 9.65 2117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19656 BF_2 205.62 1.88 4857 546683404 ERL93223.1 670 6.4e-67 hypothetical protein D910_10519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03427//PF01093//PF07690 Carbohydrate binding domain (family 19)//Clusterin//Major Facilitator Superfamily GO:0006032//GO:0055085//GO:0008219 chitin catabolic process//transmembrane transport//cell death GO:0008061 chitin binding GO:0016021 integral component of membrane -- -- Cluster-8309.19657 BF_2 44.88 2.01 1222 546676446 ERL87451.1 215 9.3e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.19660 BF_2 6.22 0.36 1005 642913216 XP_008201442.1 201 3.2e-13 PREDICTED: uncharacterized protein LOC664132 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19665 BF_2 31.00 0.54 2672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19666 BF_2 26.69 0.58 2197 642918110 XP_008194042.1 650 6.1e-65 PREDICTED: calpain-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 591 1.7e-59 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF13833//PF13405//PF00036//PF13499//PF00648//PF13202 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//Calpain family cysteine protease//EF hand GO:0006508 proteolysis GO:0004198//GO:0005509 calcium-dependent cysteine-type endopeptidase activity//calcium ion binding GO:0005622 intracellular -- -- Cluster-8309.19674 BF_2 91.42 2.70 1704 728418014 AIY68354.1 956 1.5e-100 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 341 1.3e-30 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.19680 BF_2 12.00 1.53 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19691 BF_2 12.00 1.06 762 817218794 XP_012285202.1 466 4.5e-44 PREDICTED: deoxycytidylate deaminase [Orussus abietinus] -- -- -- -- -- K01493 comEB dCMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01493 Q5RC69 410 5.8e-39 Deoxycytidylate deaminase OS=Pongo abelii GN=DCTD PE=2 SV=1 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region -- -- GO:0008270 zinc ion binding -- -- KOG3127 Deoxycytidylate deaminase Cluster-8309.19692 BF_2 261.00 4.53 2695 189237962 XP_001811853.1 1252 1.2e-134 PREDICTED: carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 [Tribolium castaneum]>gi|270006659|gb|EFA03107.1| hypothetical protein TcasGA2_TC013017 [Tribolium castaneum] 242011225 XM_002426311.1 145 3.02508e-67 Pediculus humanus corporis nuclear lim interactor-interacting factor, putative, mRNA K15731 CTDSP carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K15731 Q9GZU7 821 4.5e-86 Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 OS=Homo sapiens GN=CTDSP1 PE=1 SV=1 -- -- GO:0016311 dephosphorylation GO:0016791 phosphatase activity -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.19694 BF_2 228.01 9.67 1274 642927694 XP_008196569.1 306 2.7e-25 PREDICTED: uncharacterized protein LOC103313889 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064//PF00008 Thrombomodulin like fifth domain, EGF-like//EGF-like domain GO:0007165 signal transduction GO:0004888//GO:0005515 transmembrane signaling receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.19695 BF_2 71.77 4.55 947 499140776 AGL76355.1 265 1.1e-20 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 241 2.9e-19 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05531//PF16331//PF03998 Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation//Utp11 protein GO:0070206//GO:0006364 protein trimerization//rRNA processing -- -- GO:0032040//GO:0019028 small-subunit processome//viral capsid -- -- Cluster-8309.19696 BF_2 18.41 0.36 2436 642917000 XP_008199589.1 815 4.9e-84 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 243 4.3e-19 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19697 BF_2 20.20 0.79 1359 270016115 EFA12563.1 255 2.4e-19 hypothetical protein TcasGA2_TC004192 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.1970 BF_2 27.28 1.28 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09107 Elongation factor SelB, winged helix GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0003723//GO:0005525//GO:0003746 RNA binding//GTP binding//translation elongation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm -- -- Cluster-8309.19705 BF_2 94.28 3.42 1442 642927952 XP_008195459.1 1721 2.6e-189 PREDICTED: protein pellino isoform X1 [Tribolium castaneum]>gi|270011061|gb|EFA07509.1| hypothetical protein TcasGA2_TC009672 [Tribolium castaneum] 642927955 XM_962215.3 264 1.12905e-133 PREDICTED: Tribolium castaneum protein pellino (LOC662980), transcript variant X3, mRNA K11964 PELI pellino http://www.genome.jp/dbget-bin/www_bget?ko:K11964 O77237 1372 3.1e-150 Protein pellino OS=Drosophila melanogaster GN=Pli PE=1 SV=1 PF05203//PF04710//PF01899//PF14634 Hom_end-associated Hint//Pellino//Na+/H+ ion antiporter subunit//zinc-RING finger domain GO:0006812//GO:0030908//GO:0008063 cation transport//protein splicing//Toll signaling pathway GO:0008270//GO:0008324//GO:0005515 zinc ion binding//cation transmembrane transporter activity//protein binding GO:0016021 integral component of membrane KOG3842 Adaptor protein Pellino Cluster-8309.19708 BF_2 124.00 8.60 890 665794141 XP_008544754.1 674 4.0e-68 PREDICTED: pseudouridine-5'-monophosphatase isoform X1 [Microplitis demolitor] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 617 6.8e-63 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.19709 BF_2 92.97 9.73 687 91089817 XP_969063.1 323 1.6e-27 PREDICTED: protein anon-73B1 [Tribolium castaneum]>gi|270013595|gb|EFA10043.1| hypothetical protein TcasGA2_TC012215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06783//PF01741//PF05038 Uncharacterised protein family (UPF0239)//Large-conductance mechanosensitive channel, MscL//Cytochrome Cytochrome b558 alpha-subunit GO:0006811//GO:0006810 ion transport//transport GO:0005216//GO:0020037 ion channel activity//heme binding GO:0016021 integral component of membrane -- -- Cluster-8309.19712 BF_2 24.95 0.37 3097 478260882 ENN80519.1 1083 5.3e-115 hypothetical protein YQE_03058, partial [Dendroctonus ponderosae]>gi|546671739|gb|ERL83923.1| hypothetical protein D910_01216 [Dendroctonus ponderosae]>gi|546675041|gb|ERL86299.1| hypothetical protein D910_03707 [Dendroctonus ponderosae] 572257831 XM_006607250.1 36 1.36348e-06 PREDICTED: Apis dorsata tyrosine-protein kinase PR2-like (LOC102681833), mRNA -- -- -- -- Q9I7F7 244 4.2e-19 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF03943//PF01529//PF06423 TAP C-terminal domain//DHHC palmitoyltransferase//GWT1 GO:0006506//GO:0051028 GPI anchor biosynthetic process//mRNA transport GO:0008270//GO:0016746 zinc ion binding//transferase activity, transferring acyl groups GO:0005789//GO:0016021//GO:0005634 endoplasmic reticulum membrane//integral component of membrane//nucleus -- -- Cluster-8309.19713 BF_2 817.00 19.94 2001 478255561 ENN75778.1 361 1.8e-31 hypothetical protein YQE_07735, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O42976 179 9.4e-12 Uncharacterized membrane protein C20F10.07 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC20F10.07 PE=1 SV=1 PF15168 Triple QxxK/R motif-containing protein family -- -- -- -- GO:0005789 endoplasmic reticulum membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.19714 BF_2 69.45 1.56 2151 642928668 XP_008199729.1 1704 3.6e-187 PREDICTED: protein daughterless isoform X6 [Tribolium castaneum] 642928667 XM_008201507.1 306 7.62542e-157 PREDICTED: Tribolium castaneum protein daughterless (LOC662057), transcript variant X6, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 591 1.7e-59 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010//PF02854 Helix-loop-helix DNA-binding domain//MIF4G domain -- -- GO:0005515//GO:0046983//GO:0003723 protein binding//protein dimerization activity//RNA binding -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.19715 BF_2 16.81 0.38 2146 642922624 XP_008193254.1 269 9.0e-21 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19723 BF_2 48.72 0.62 3583 270011744 EFA08192.1 887 3.3e-92 hypothetical protein TcasGA2_TC005819 [Tribolium castaneum] -- -- -- -- -- K10773 NTH endonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K10773 Q2KID2 739 1.9e-76 Endonuclease III-like protein 1 OS=Bos taurus GN=NTHL1 PE=2 SV=1 PF00633//PF16045//PF09398//PF00730 Helix-hairpin-helix motif//LisH//FOP N terminal dimerisation domain//HhH-GPD superfamily base excision DNA repair protein GO:0034453//GO:0006284 microtubule anchoring//base-excision repair GO:0005515//GO:0003677 protein binding//DNA binding GO:0005815 microtubule organizing center KOG1921 Endonuclease III Cluster-8309.19735 BF_2 643.30 115.03 521 478257192 ENN77355.1 190 3.1e-12 hypothetical protein YQE_06180, partial [Dendroctonus ponderosae]>gi|546681401|gb|ERL91498.1| hypothetical protein D910_08828 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19736 BF_2 481.00 14.35 1689 332372586 AEE61435.1 925 6.0e-97 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15109 SLC25A20_29, CACT, CACL, CRC1 solute carrier family 25 (mitochondrial carnitine/acylcarnitine transporter), member 20/29 http://www.genome.jp/dbget-bin/www_bget?ko:K15109 Q08DK7 613 3.7e-62 Mitochondrial basic amino acids transporter OS=Bos taurus GN=SLC25A29 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0758 Mitochondrial carnitine-acylcarnitine carrier protein Cluster-8309.1974 BF_2 3.00 0.37 624 826280638 XP_012495185.1 1049 9.3e-112 PREDICTED: 78 kDa glucose-regulated protein [Propithecus coquereli] 305855105 NM_005347.4 624 0 Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5), mRNA K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 P11021 1049 3.8e-113 78 kDa glucose-regulated protein OS=Homo sapiens GN=HSPA5 PE=1 SV=2 PF09236//PF01968//PF06723//PF02782 Alpha-haemoglobin stabilising protein//Hydantoinase/oxoprolinase//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0020027//GO:0000902//GO:0030097//GO:0005975//GO:0006457//GO:0050821 hemoglobin metabolic process//cell morphogenesis//hemopoiesis//carbohydrate metabolic process//protein folding//protein stabilization GO:0016773//GO:0030492//GO:0016787 phosphotransferase activity, alcohol group as acceptor//hemoglobin binding//hydrolase activity GO:0005833 hemoglobin complex KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-8309.19740 BF_2 36.37 0.35 4642 642912393 XP_008199488.1 3395 0.0e+00 PREDICTED: liprin-alpha-1 isoform X6 [Tribolium castaneum] 642912404 XM_008201272.1 811 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X12, mRNA -- -- -- -- Q13136 1594 1.8e-175 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF02459//PF05513 Adenoviral DNA terminal protein//TraA GO:0006260//GO:0000746 DNA replication//conjugation GO:0003677 DNA binding GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.19744 BF_2 294.00 8.49 1735 91080479 XP_970655.1 1220 3.8e-131 PREDICTED: peroxisomal membrane protein PEX16 [Tribolium castaneum]>gi|270005559|gb|EFA02007.1| hypothetical protein TcasGA2_TC007629 [Tribolium castaneum] -- -- -- -- -- K13335 PEX16 peroxin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K13335 Q4QRH7 645 7.5e-66 Peroxisomal membrane protein PEX16 OS=Danio rerio GN=pex16 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19745 BF_2 37.44 0.79 2278 642925556 XP_971635.2 645 2.4e-64 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52845 368 1.3e-33 Estrogen sulfotransferase, isoform 2 OS=Rattus norvegicus GN=Ste2 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.19748 BF_2 8.70 0.51 1000 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19749 BF_2 69.47 3.05 1239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19754 BF_2 16.00 0.83 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19758 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19764 BF_2 15.08 0.60 1342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19770 BF_2 26.00 0.58 2160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02444 Hepatitis E virus ORF-2 (Putative capsid protein) -- -- -- -- GO:0030430 host cell cytoplasm -- -- Cluster-8309.19772 BF_2 6.10 0.33 1067 546683609 ERL93397.1 233 6.6e-17 hypothetical protein D910_10689, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02417//PF01601//PF05478//PF04579 Chromate transporter//Coronavirus S2 glycoprotein//Prominin//Keratin, high-sulphur matrix protein GO:0015703//GO:0061025//GO:0046813 chromate transport//membrane fusion//receptor-mediated virion attachment to host cell GO:0005198//GO:0015109 structural molecule activity//chromate transmembrane transporter activity GO:0016021//GO:0019031//GO:0045095 integral component of membrane//viral envelope//keratin filament -- -- Cluster-8309.19773 BF_2 2.00 0.44 477 270014998 EFA11446.1 264 7.5e-21 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19774 BF_2 235.92 5.08 2228 91086413 XP_967009.1 1442 8.9e-157 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270010301|gb|EFA06749.1| hypothetical protein TcasGA2_TC009683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MYA4 555 2.6e-55 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.19776 BF_2 5.00 0.37 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19778 BF_2 111.00 2.91 1884 642928879 XP_008195599.1 1557 3.5e-170 PREDICTED: uncharacterized protein F21D5.5 [Tribolium castaneum]>gi|642928881|ref|XP_008195600.1| PREDICTED: uncharacterized protein F21D5.5 [Tribolium castaneum]>gi|270009738|gb|EFA06186.1| hypothetical protein TcasGA2_TC009034 [Tribolium castaneum] -- -- -- -- -- K08073 PNKP bifunctional polynucleotide phosphatase/kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08073 Q96T60 896 6.4e-95 Bifunctional polynucleotide phosphatase/kinase OS=Homo sapiens GN=PNKP PE=1 SV=1 PF00910//PF06414//PF03601 RNA helicase//Zeta toxin//Conserved hypothetical protein 698 -- -- GO:0003724//GO:0016301//GO:0005524//GO:0003723 RNA helicase activity//kinase activity//ATP binding//RNA binding GO:0016021 integral component of membrane KOG2134 Polynucleotide kinase 3' phosphatase Cluster-8309.19779 BF_2 465.38 9.77 2280 270010353 EFA06801.1 1544 1.4e-168 hypothetical protein TcasGA2_TC009740 [Tribolium castaneum] 665795469 XM_008547261.1 239 1.42252e-119 PREDICTED: Microplitis demolitor cyclin-dependent kinase 5 (LOC103569778), mRNA K02090 CDK5 cyclin-dependent kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02090 P51166 1313 3.4e-143 Cyclin-dependent-like kinase 5 OS=Xenopus laevis GN=cdk5 PE=2 SV=1 PF02109//PF07714//PF00069 DAD family//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0018279 protein phosphorylation//protein N-linked glycosylation via asparagine GO:0005524//GO:0004579//GO:0004672 ATP binding//dolichyl-diphosphooligosaccharide-protein glycotransferase activity//protein kinase activity GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.19780 BF_2 2.00 0.38 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19781 BF_2 183.49 4.46 2010 642917401 XP_008191181.1 1711 5.2e-188 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Tribolium castaneum] 167777849 CP000786.1 38 6.80291e-08 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome I, complete sequence -- -- -- -- A1L258 1469 2.5e-161 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF02913//PF01565 FAD linked oxidases, C-terminal domain//FAD binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0050660//GO:0003824 oxidoreductase activity//flavin adenine dinucleotide binding//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.19784 BF_2 10.00 0.79 815 817087870 XP_012266730.1 217 3.6e-15 PREDICTED: uncharacterized protein LOC105692236 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19787 BF_2 21.42 0.31 3215 861634002 KMQ91126.1 968 1.2e-101 dna pol b2 domain-containing protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04574//PF09198 Protein of unknown function (DUF592)//Bacteriophage T4 beta-glucosyltransferase GO:0006807//GO:0006304//GO:0006355//GO:0006476//GO:0006342 nitrogen compound metabolic process//DNA modification//regulation of transcription, DNA-templated//protein deacetylation//chromatin silencing GO:0008270//GO:0033821//GO:0017136//GO:0051287//GO:0016811 zinc ion binding//DNA beta-glucosyltransferase activity//NAD-dependent histone deacetylase activity//NAD binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0000118 histone deacetylase complex -- -- Cluster-8309.19789 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19791 BF_2 353.92 12.20 1501 642914715 XP_008199944.1 1273 2.4e-137 PREDICTED: BTB/POZ domain-containing protein kctd15-like [Tribolium castaneum] 642914714 XM_008201722.1 359 0 PREDICTED: Tribolium castaneum BTB/POZ domain-containing protein kctd15-like (LOC654911), mRNA -- -- -- -- Q8K0E1 655 4.5e-67 BTB/POZ domain-containing protein KCTD15 OS=Mus musculus GN=Kctd15 PE=1 SV=1 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.19797 BF_2 462.00 19.04 1302 546679312 ERL89799.1 657 5.5e-66 hypothetical protein D910_07160 [Dendroctonus ponderosae] -- -- -- -- -- K01352 GZMA granzyme A http://www.genome.jp/dbget-bin/www_bget?ko:K01352 O97398 432 2.8e-41 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.198 BF_2 4.00 0.66 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19800 BF_2 14.00 0.50 1458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19802 BF_2 90.00 6.73 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19803 BF_2 20.65 13.50 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19804 BF_2 9.35 1.19 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19805 BF_2 81.36 5.93 861 546681999 ERL91995.1 545 3.5e-53 hypothetical protein D910_09317 [Dendroctonus ponderosae] -- -- -- -- -- K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 354 2.1e-32 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF11910//PF16499 Cyanobacterial and plant NDH-1 subunit O//Alpha galactosidase A GO:0006118//GO:0005975//GO:0055114 obsolete electron transport//carbohydrate metabolic process//oxidation-reduction process GO:0004553//GO:0016655 hydrolase activity, hydrolyzing O-glycosyl compounds//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005886 plasma membrane KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.19806 BF_2 225.02 11.20 1128 332374122 AEE62202.1 734 5.6e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9D0I8 597 1.8e-60 mRNA turnover protein 4 homolog OS=Mus musculus GN=Mrto4 PE=2 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.19808 BF_2 17.02 0.43 1957 861605580 KMQ84383.1 273 2.8e-21 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19811 BF_2 2.00 0.63 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19822 BF_2 9.70 0.88 751 91083531 XP_973193.1 329 3.4e-28 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q3SZD7 245 7.8e-20 Carbonyl reductase [NADPH] 1 OS=Bos taurus GN=CBR1 PE=2 SV=1 -- -- GO:0008152 metabolic process -- -- -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.19824 BF_2 4.00 0.39 721 16903179 AAK61417.1 621 4.6e-62 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19825 BF_2 18.22 0.32 2664 642919019 XP_008191698.1 900 7.5e-94 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P1I3 328 6.6e-29 UPF0536 protein C12orf66 homolog OS=Mus musculus PE=1 SV=1 PF15234 Linker for activation of T-cells GO:0007165 signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.19826 BF_2 133.01 10.10 838 91083983 XP_975195.1 539 1.7e-52 PREDICTED: 39S ribosomal protein L20, mitochondrial [Tribolium castaneum]>gi|270006712|gb|EFA03160.1| hypothetical protein TcasGA2_TC013079 [Tribolium castaneum] -- -- -- -- -- K02887 RP-L20, MRPL20, rplT large subunit ribosomal protein L20 http://www.genome.jp/dbget-bin/www_bget?ko:K02887 Q5U4Z8 307 5.6e-27 39S ribosomal protein L20, mitochondrial OS=Xenopus laevis GN=mrpl20 PE=2 SV=1 PF00453 Ribosomal protein L20 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005622//GO:0005840 intracellular//ribosome KOG4707 Mitochondrial/chloroplast ribosomal protein L20 Cluster-8309.19828 BF_2 42.34 1.20 1766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04272 Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0005246//GO:0042030 calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.19835 BF_2 374.64 7.47 2384 478256682 ENN76864.1 1389 1.3e-150 hypothetical protein YQE_06705, partial [Dendroctonus ponderosae]>gi|546685121|gb|ERL94648.1| hypothetical protein D910_11923 [Dendroctonus ponderosae] -- -- -- -- -- K01792 E5.1.3.15 glucose-6-phosphate 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01792 Q03161 400 2.6e-37 Glucose-6-phosphate 1-epimerase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YMR099C PE=1 SV=1 PF05197//PF01263 TRIC channel//Aldose 1-epimerase GO:0015672//GO:0006812//GO:0005975 monovalent inorganic cation transport//cation transport//carbohydrate metabolic process GO:0005261//GO:0016853 cation channel activity//isomerase activity GO:0016020 membrane KOG1594 Uncharacterized enzymes related to aldose 1-epimerase Cluster-8309.19837 BF_2 756.40 8.25 4124 642932284 XP_008197048.1 2639 2.6e-295 PREDICTED: lysosomal alpha-mannosidase-like [Tribolium castaneum]>gi|270012319|gb|EFA08767.1| hypothetical protein TcasGA2_TC006455 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q8VHC8 1568 1.7e-172 Lysosomal alpha-mannosidase OS=Cavia porcellus GN=MAN2B1 PE=1 SV=1 PF04805//PF01074//PF07748//PF09261 E10-like protein conserved region//Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Alpha mannosidase, middle domain GO:0005975//GO:0055114//GO:0006013 carbohydrate metabolic process//oxidation-reduction process//mannose metabolic process GO:0008270//GO:0005488//GO:0016972//GO:0004553//GO:0015923//GO:0004559 zinc ion binding//binding//thiol oxidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//mannosidase activity//alpha-mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.19838 BF_2 81.92 5.53 907 270002738 EEZ99185.1 595 6.0e-59 serine protease H6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BLP6 245 9.4e-20 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19850 BF_2 486.80 5.70 3860 91094617 XP_968941.1 1978 1.1e-218 PREDICTED: NEDD4-binding protein 2 [Tribolium castaneum]>gi|270016434|gb|EFA12880.1| hypothetical protein TcasGA2_TC011558 [Tribolium castaneum] -- -- -- -- -- K15720 N4BP2 NEDD4-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15720 Q92802 379 1.2e-34 NEDD4-binding protein 2-like 2 OS=Homo sapiens GN=N4BP2L2 PE=1 SV=1 PF01234//PF06414//PF02845 NNMT/PNMT/TEMT family//Zeta toxin//CUE domain -- -- GO:0005515//GO:0016301//GO:0008168//GO:0005524 protein binding//kinase activity//methyltransferase activity//ATP binding -- -- KOG2401 Predicted MutS-related protein involved in mismatch repair Cluster-8309.19853 BF_2 657.99 467.89 340 111182472 ABH07674.1 334 4.1e-29 gut-specific chitinase [Apriona germari]>gi|111182474|gb|ABH07675.1| gut-specific chitinase [Apriona germari] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 178 2.1e-12 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975//GO:0016998//GO:0006032 carbohydrate metabolic process//cell wall macromolecule catabolic process//chitin catabolic process GO:0004568//GO:0043169//GO:0004553 chitinase activity//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.19854 BF_2 36.40 0.35 4695 390362249 XP_001190749.2 1582 1.1e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 2.6e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF08100//PF00906//PF13606//PF00023//PF00866//PF04069 Dimerisation domain//Hepatitis core antigen//Ankyrin repeat//Ankyrin repeat//Ring hydroxylating beta subunit//Substrate binding domain of ABC-type glycine betaine transport system GO:0006725//GO:0055114//GO:0006810//GO:0009405 cellular aromatic compound metabolic process//oxidation-reduction process//transport//pathogenesis GO:0005515//GO:0046983//GO:0005215//GO:0005198//GO:0003824 protein binding//protein dimerization activity//transporter activity//structural molecule activity//catalytic activity -- -- -- -- Cluster-8309.19858 BF_2 266.29 5.58 2282 91080889 XP_973062.1 2602 2.8e-291 PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 2 [Tribolium castaneum]>gi|270005396|gb|EFA01844.1| hypothetical protein TcasGA2_TC007447 [Tribolium castaneum] 462316750 APGK01044966.1 63 9.80183e-22 Dendroctonus ponderosae Seq01044976, whole genome shotgun sequence K10085 EDEM2 ER degradation enhancer, mannosidase alpha-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10085 Q9BV94 1655 7.5e-183 ER degradation-enhancing alpha-mannosidase-like protein 2 OS=Homo sapiens GN=EDEM2 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2429 Glycosyl hydrolase, family 47 Cluster-8309.19859 BF_2 1.00 2.33 279 21758619 BAC05339.1 163 2.3e-09 unnamed protein product [Homo sapiens] 10881086 AC083869.2 224 3.4002e-112 AC083869 Homo sapiens chromosome 7 clone RP11-733N14, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19862 BF_2 350.17 8.29 2055 91076222 XP_972737.1 1328 1.4e-143 PREDICTED: protein phosphatase methylesterase 1 [Tribolium castaneum]>gi|270014549|gb|EFA10997.1| hypothetical protein TcasGA2_TC004582 [Tribolium castaneum] -- -- -- -- -- K13617 PPME1 protein phosphatase methylesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13617 Q8BVQ5 851 1.2e-89 Protein phosphatase methylesterase 1 OS=Mus musculus GN=Ppme1 PE=1 SV=5 PF00975//PF07859//PF07819//PF12740//PF01764 Thioesterase domain//alpha/beta hydrolase fold//PGAP1-like protein//Chlorophyllase enzyme//Lipase (class 3) GO:0015996//GO:0006505//GO:0008152//GO:0006629//GO:0006886//GO:0015994//GO:0009058 chlorophyll catabolic process//GPI anchor metabolic process//metabolic process//lipid metabolic process//intracellular protein transport//chlorophyll metabolic process//biosynthetic process GO:0016787//GO:0016788//GO:0047746 hydrolase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity -- -- KOG2564 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold Cluster-8309.19863 BF_2 504.05 3.70 5980 642920211 XP_008192250.1 2586 5.3e-289 PREDICTED: LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11 [Tribolium castaneum] 721631354 XM_003567893.2 45 2.629e-11 PREDICTED: Brachypodium distachyon mannose-6-phosphate isomerase 1 (LOC100835530), mRNA K11273 DDX11, CHL1, CTF1 chromosome transmission fidelity protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11273 Q92771 1452 6.8e-159 Putative ATP-dependent RNA helicase DDX12 OS=Homo sapiens GN=DDX12P PE=5 SV=3 PF01416//PF04851//PF02562//PF08471//PF06733//PF02944//PF01238//PF00170//PF13307 tRNA pseudouridine synthase//Type III restriction enzyme, res subunit//PhoH-like protein//Class II vitamin B12-dependent ribonucleotide reductase//DEAD_2//BESS motif//Phosphomannose isomerase type I//bZIP transcription factor//Helicase C-terminal domain GO:0006139//GO:0006355//GO:0001522//GO:0055114//GO:0005975//GO:0006000//GO:0009186//GO:0006144//GO:0006206//GO:0009451//GO:0006013 nucleobase-containing compound metabolic process//regulation of transcription, DNA-templated//pseudouridine synthesis//oxidation-reduction process//carbohydrate metabolic process//fructose metabolic process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//RNA modification//mannose metabolic process GO:0005524//GO:0016787//GO:0004476//GO:0008270//GO:0043565//GO:0009982//GO:0004003//GO:0003700//GO:0050897//GO:0016818//GO:0003723//GO:0003677//GO:0008026//GO:0004748//GO:0003676 ATP binding//hydrolase activity//mannose-6-phosphate isomerase activity//zinc ion binding//sequence-specific DNA binding//pseudouridine synthase activity//ATP-dependent DNA helicase activity//transcription factor activity, sequence-specific DNA binding//cobalt ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//RNA binding//DNA binding//ATP-dependent helicase activity//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//nucleic acid binding GO:0005657//GO:0005667//GO:0005971 replication fork//transcription factor complex//ribonucleoside-diphosphate reductase complex KOG1133 Helicase of the DEAD superfamily Cluster-8309.19864 BF_2 397.17 7.65 2459 189239355 XP_974286.2 3169 0.0e+00 PREDICTED: ATP-dependent RNA helicase Ddx1 [Tribolium castaneum]>gi|270009695|gb|EFA06143.1| hypothetical protein TcasGA2_TC008987 [Tribolium castaneum] -- -- -- -- -- K13177 DDX1 ATP-dependent RNA helicase DDX1 http://www.genome.jp/dbget-bin/www_bget?ko:K13177 Q9VNV3 2546 3.9e-286 ATP-dependent RNA helicase Ddx1 OS=Drosophila melanogaster GN=Ddx1 PE=2 SV=1 PF00622//PF00270 SPRY domain//DEAD/DEAH box helicase -- -- GO:0008026//GO:0005515//GO:0005524//GO:0003676 ATP-dependent helicase activity//protein binding//ATP binding//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.19869 BF_2 194.10 3.66 2507 642910817 XP_008193421.1 1463 3.7e-159 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 9.9e-27 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19872 BF_2 4.00 0.37 734 817343900 XP_012297422.1 148 3.3e-07 PREDICTED: COP9 signalosome complex subunit 3 [Aotus nancymaae] 316659408 NM_001199954.1 734 0 Homo sapiens actin gamma 1 (ACTG1), transcript variant 1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19874 BF_2 8.00 0.54 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19876 BF_2 7.00 0.49 881 195499002 XP_002087146.1 258 6.9e-20 GE14720 [Drosophila yakuba]>gi|194186817|gb|EDX00429.1| GE14720 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.19877 BF_2 17.00 0.46 1836 270017019 EFA13465.1 859 2.9e-89 hypothetical protein TcasGA2_TC004276 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 169 1.2e-10 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF09668//PF06305//PF00098 Aspartyl protease//Protein of unknown function (DUF1049)//Zinc knuckle GO:0006508 proteolysis GO:0004190//GO:0003676//GO:0008270 aspartic-type endopeptidase activity//nucleic acid binding//zinc ion binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.19878 BF_2 4.00 0.73 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19879 BF_2 355.42 2.37 6572 642925278 XP_008194489.1 2317 9.1e-258 PREDICTED: PAX-interacting protein 1 [Tribolium castaneum]>gi|270009278|gb|EFA05726.1| hypothetical protein TcasGA2_TC015410 [Tribolium castaneum] -- -- -- -- -- K14972 PAXIP1, PTIP PAX-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14972 A0JNA8 692 1.0e-70 PAX-interacting protein 1 OS=Bos taurus GN=PAXIP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.19884 BF_2 103.12 0.48 9291 642911642 XP_008200683.1 12603 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurofibromin [Tribolium castaneum] 751776924 XM_011199144.1 429 0 PREDICTED: Bactrocera dorsalis neurofibromin (LOC105221988), mRNA K08052 NF1 neurofibromin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08052 P97526 6308 0.0e+00 Neurofibromin OS=Rattus norvegicus GN=Nf1 PE=1 SV=1 PF09090//PF12356//PF00616 MIF4G like//Protein of unknown function (DUF3643)//GTPase-activator protein for Ras-like GTPase GO:0043087//GO:0032465//GO:0006915//GO:0016567//GO:0016070 regulation of GTPase activity//regulation of cytokinesis//apoptotic process//protein ubiquitination//RNA metabolic process GO:0004842 ubiquitin-protein transferase activity -- -- KOG1826 Ras GTPase activating protein RasGAP/neurofibromin Cluster-8309.19886 BF_2 13.00 2.13 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19889 BF_2 374.00 3.40 4888 642927783 XP_008195404.1 4878 0.0e+00 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase 4 [Tribolium castaneum]>gi|270009882|gb|EFA06330.1| hypothetical protein TcasGA2_TC009201 [Tribolium castaneum] -- -- -- -- -- K16196 EIF2AK4 eukaryotic translation initiation factor 2-alpha kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16196 Q9P2K8 2284 1.9e-255 Eukaryotic translation initiation factor 2-alpha kinase 4 OS=Homo sapiens GN=EIF2AK4 PE=1 SV=3 PF00069//PF05773//PF07714 Protein kinase domain//RWD domain//Protein tyrosine kinase GO:0044267//GO:0016310//GO:0006468//GO:0009069 cellular protein metabolic process//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0000166//GO:0005515//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//nucleotide binding//protein binding//ATP binding -- -- KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.1989 BF_2 4.80 1.13 464 91085131 XP_969556.1 409 1.1e-37 PREDICTED: peptidoglycan-recognition protein LB isoform X1 [Tribolium castaneum]>gi|270009296|gb|EFA05744.1| hypothetical protein TcasGA2_TC015689 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q8INK6 316 2.8e-28 Peptidoglycan-recognition protein LB OS=Drosophila melanogaster GN=PGRP-LB PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009253//GO:0006807//GO:0009252 peptidoglycan catabolic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.19891 BF_2 21.04 1.83 768 91083069 XP_967587.1 495 2.0e-47 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q0KI50 245 8.0e-20 Dystrophin, isoform D OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF02183//PF02601//PF04977//PF14073//PF04632//PF13851//PF10473//PF01166//PF11802//PF11365//PF07716//PF08826//PF16473//PF04065//PF06156//PF04111//PF04871//PF00170//PF10186//PF06005 Homeobox associated leucine zipper//Exonuclease VII, large subunit//Septum formation initiator//Centrosome localisation domain of Cep57//Fusaric acid resistance protein family//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family//Centromere-associated protein K//Protein of unknown function (DUF3166)//Basic region leucine zipper//DMPK coiled coil domain like//Domain of unknown function (DUF5051)//Not1 N-terminal domain, CCR4-Not complex component//Protein of unknown function (DUF972)//Autophagy protein Apg6//Uso1 / p115 like vesicle tethering protein, C terminal region//bZIP transcription factor//Vacuolar sorting 38 and autophagy-related subunit 14//Protein of unknown function (DUF904) GO:0000917//GO:0043093//GO:0006308//GO:0006886//GO:0006810//GO:0006468//GO:0006914//GO:0009069//GO:0015031//GO:0007049//GO:0010508//GO:0006355//GO:0048870//GO:0016310//GO:0010506//GO:0006260 barrier septum assembly//FtsZ-dependent cytokinesis//DNA catabolic process//intracellular protein transport//transport//protein phosphorylation//autophagy//serine family amino acid metabolic process//protein transport//cell cycle//positive regulation of autophagy//regulation of transcription, DNA-templated//cell motility//phosphorylation//regulation of autophagy//DNA replication GO:0008855//GO:0042802//GO:0043015//GO:0042803//GO:0008565//GO:0043565//GO:0003676//GO:0043169//GO:0008134//GO:0045502//GO:0005524//GO:0004674//GO:0003700 exodeoxyribonuclease VII activity//identical protein binding//gamma-tubulin binding//protein homodimerization activity//protein transporter activity//sequence-specific DNA binding//nucleic acid binding//cation binding//transcription factor binding//dynein binding//ATP binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding GO:0005886//GO:0005634//GO:0016020//GO:0031514//GO:0005737//GO:0005667//GO:0030286//GO:0045298//GO:0005615//GO:0009318 plasma membrane//nucleus//membrane//motile cilium//cytoplasm//transcription factor complex//dynein complex//tubulin complex//extracellular space//exodeoxyribonuclease VII complex -- -- Cluster-8309.19893 BF_2 116.31 1.56 3416 642937039 XP_008198663.1 2804 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X4 [Tribolium castaneum] 501300159 AK418404.1 119 1.09208e-52 Riptortus pedestris mRNA for cytoplasmic dynein intermediate chain, partial cds, sequence id: Rped-0877, expressed in midgut K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 2006 2.2e-223 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400//PF09266//PF11540 WD domain, G-beta repeat//Viral DNA topoisomerase I, N-terminal//Cytoplasmic dynein 1 intermediate chain 2 GO:0007018//GO:0006265 microtubule-based movement//DNA topological change GO:0003677//GO:0005515//GO:0003916 DNA binding//protein binding//DNA topoisomerase activity GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.19900 BF_2 32.37 0.44 3384 478255416 ENN75638.1 1298 6.8e-140 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 987 3.2e-105 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF00288//PF04627 GHMP kinases N terminal domain//Mitochondrial ATP synthase epsilon chain GO:0006119//GO:0015986//GO:0015992 oxidative phosphorylation//ATP synthesis coupled proton transport//proton transport GO:0005524//GO:0046933//GO:0046961 ATP binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.19901 BF_2 5.00 0.37 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19903 BF_2 389.82 10.59 1827 332373656 AEE61969.1 1637 1.8e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 388 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 Q5R6K8 1586 6.0e-175 Serine/threonine-protein phosphatase 4 catalytic subunit OS=Pongo abelii GN=PPP4C PE=2 SV=1 PF01429//PF00149 Methyl-CpG binding domain//Calcineurin-like phosphoesterase -- -- GO:0016787//GO:0003677 hydrolase activity//DNA binding GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.19904 BF_2 213.00 6.22 1720 642929591 XP_008195896.1 1048 3.3e-111 PREDICTED: protein LTV1 homolog [Tribolium castaneum]>gi|270010989|gb|EFA07437.1| hypothetical protein TcasGA2_TC008848 [Tribolium castaneum] -- -- -- -- -- K14798 LTV1 protein LTV1 http://www.genome.jp/dbget-bin/www_bget?ko:K14798 Q4V838 689 5.9e-71 Protein LTV1 homolog OS=Xenopus laevis GN=ltv1 PE=2 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- KOG2637 Uncharacterized conserved protein Cluster-8309.19905 BF_2 215.09 1.70 5586 429544803 AGA01579.1 2323 1.6e-258 cryptochrome 2 [Rhyparobia maderae] 801397565 XM_012203803.1 258 9.63736e-130 PREDICTED: Atta cephalotes cryptochrome-1-like (LOC105622379), mRNA K02295 CRY cryptochrome http://www.genome.jp/dbget-bin/www_bget?ko:K02295 P97784 1966 1.6e-218 Cryptochrome-1 OS=Mus musculus GN=Cry1 PE=1 SV=1 PF16622//PF13912//PF00096//PF13465 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG0133 Deoxyribodipyrimidine photolyase/cryptochrome Cluster-8309.19906 BF_2 15.49 0.40 1888 641664992 XP_008183213.1 994 6.7e-105 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 923 4.7e-98 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF16622//PF07776//PF13912//PF07975//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.19907 BF_2 30.01 3.94 606 642928567 XP_008199961.1 527 3.0e-51 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 461 5.6e-45 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.19909 BF_2 27.86 0.85 1652 642922501 XP_008193198.1 1020 5.7e-108 PREDICTED: uncharacterized protein LOC103312982 [Tribolium castaneum]>gi|270007489|gb|EFA03937.1| hypothetical protein TcasGA2_TC014078 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19910 BF_2 563.14 18.32 1573 642922501 XP_008193198.1 1020 5.4e-108 PREDICTED: uncharacterized protein LOC103312982 [Tribolium castaneum]>gi|270007489|gb|EFA03937.1| hypothetical protein TcasGA2_TC014078 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19913 BF_2 19.00 5.32 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19918 BF_2 23.00 0.51 2187 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19921 BF_2 208.00 11.86 1021 478252450 ENN72872.1 369 1.1e-32 hypothetical protein YQE_10442, partial [Dendroctonus ponderosae]>gi|546685970|gb|ERL95381.1| hypothetical protein D910_12645 [Dendroctonus ponderosae] -- -- -- -- -- K18170 LYRM7, MZM1 complex III assembly factor LYRM7 http://www.genome.jp/dbget-bin/www_bget?ko:K18170 A5PLG0 212 7.1e-16 Complex III assembly factor LYRM7 OS=Danio rerio GN=LYRM7 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19924 BF_2 324.87 6.96 2239 642927688 XP_008196543.1 1021 5.9e-108 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 1.0e-27 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF00128//PF13855 Alpha amylase, catalytic domain//Leucine rich repeat GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824//GO:0005515 cation binding//catalytic activity//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.19925 BF_2 65.50 0.72 4068 270012188 EFA08636.1 1740 4.5e-191 hypothetical protein TcasGA2_TC006299 [Tribolium castaneum] -- -- -- -- -- K08803 DAPK death-associated protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08803 O44997 489 2.2e-47 Death-associated protein kinase dapk-1 OS=Caenorhabditis elegans GN=dapk-1 PE=2 SV=2 PF00531//PF13508//PF00583//PF04558 Death domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 GO:0042967//GO:0007165//GO:0006418 acyl-carrier-protein biosynthetic process//signal transduction//tRNA aminoacylation for protein translation GO:0008080//GO:0005515//GO:0005524//GO:0004812//GO:0000166 N-acetyltransferase activity//protein binding//ATP binding//aminoacyl-tRNA ligase activity//nucleotide binding GO:0005737 cytoplasm -- -- Cluster-8309.19928 BF_2 31.00 10.08 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.19929 BF_2 2.64 0.79 426 270014998 EFA11446.1 249 3.7e-19 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19930 BF_2 19.59 1.18 983 91094767 XP_967707.1 315 1.9e-26 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P80457 246 7.8e-20 Xanthine dehydrogenase/oxidase OS=Bos taurus GN=XDH PE=1 SV=4 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0005488//GO:0016491 binding//oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19931 BF_2 2.00 2.06 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19932 BF_2 3.00 0.45 567 270014998 EFA11446.1 390 2.2e-35 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8GUQ8 156 1.2e-09 Xanthine dehydrogenase 1 OS=Arabidopsis thaliana GN=XDH1 PE=1 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19933 BF_2 12.00 3.50 430 270014998 EFA11446.1 219 1.1e-15 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19935 BF_2 9.36 3.55 396 270014998 EFA11446.1 191 1.8e-12 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.19938 BF_2 21.41 1.15 1066 91094767 XP_967707.1 315 2.1e-26 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P80457 246 8.5e-20 Xanthine dehydrogenase/oxidase OS=Bos taurus GN=XDH PE=1 SV=4 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0005488 oxidoreductase activity//binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19939 BF_2 15.01 0.66 1239 270014998 EFA11446.1 778 4.9e-80 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q852M1 411 7.3e-39 Probable aldehyde oxidase 2 OS=Oryza sativa subsp. japonica GN=Os03g0790900 PE=2 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19941 BF_2 1.00 15.80 222 642939494 XP_008190865.1 193 5.9e-13 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0016491//GO:0016614//GO:0051537//GO:0005506//GO:0050660//GO:0009055 oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//2 iron, 2 sulfur cluster binding//iron ion binding//flavin adenine dinucleotide binding//electron carrier activity -- -- -- -- Cluster-8309.19943 BF_2 25.82 1.16 1215 270014998 EFA11446.1 432 6.4e-40 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P48034 234 2.4e-18 Aldehyde oxidase 1 OS=Bos taurus GN=AOX1 PE=1 SV=2 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19944 BF_2 25.59 0.92 1448 91094767 XP_967707.1 549 2.1e-53 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5QE79 333 9.4e-30 Aldehyde oxidase 4 OS=Rattus norvegicus GN=Aox4 PE=2 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0043167//GO:0003824 oxidoreductase activity//ion binding//catalytic activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19945 BF_2 2.00 6.65 266 91094767 XP_967707.1 132 8.5e-06 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19946 BF_2 28.83 1.32 1202 91094767 XP_967707.1 697 1.2e-70 PREDICTED: xanthine dehydrogenase/oxidase [Tribolium castaneum]>gi|270016567|gb|EFA13013.1| hypothetical protein TcasGA2_TC001978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q852M1 388 3.3e-36 Probable aldehyde oxidase 2 OS=Oryza sativa subsp. japonica GN=Os03g0790900 PE=2 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0043167//GO:0003824//GO:0016491 ion binding//catalytic activity//oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.19947 BF_2 105.00 2.73 1895 332375064 AEE62673.1 354 1.1e-30 unknown [Dendroctonus ponderosae]>gi|478249845|gb|ENN70352.1| hypothetical protein YQE_12860, partial [Dendroctonus ponderosae]>gi|546671451|gb|ERL83760.1| hypothetical protein D910_00980 [Dendroctonus ponderosae]>gi|546672508|gb|ERL84338.1| hypothetical protein D910_01758 [Dendroctonus ponderosae]>gi|546686966|gb|ERL95929.1| hypothetical protein D910_00611 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 284 5.9e-24 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.1995 BF_2 30.65 0.95 1631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19952 BF_2 155.00 4.88 1616 91085361 XP_971346.1 1115 5.4e-119 PREDICTED: zinc carboxypeptidase [Tribolium castaneum]>gi|270009301|gb|EFA05749.1| hypothetical protein TcasGA2_TC015782 [Tribolium castaneum] -- -- -- -- -- K08779 CPA1 carboxypeptidase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K08779 O02350 831 1.9e-87 Zinc carboxypeptidase A 1 OS=Anopheles gambiae GN=AGAP009593 PE=2 SV=3 PF00246//PF02244 Zinc carboxypeptidase//Carboxypeptidase activation peptide GO:0006508 proteolysis GO:0004180//GO:0004181//GO:0008270 carboxypeptidase activity//metallocarboxypeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.19954 BF_2 24.90 0.34 3393 270013573 EFA10021.1 1447 3.6e-157 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3KS81 141 4.1e-07 Serine/arginine repetitive matrix protein 5 OS=Homo sapiens GN=SRRM5 PE=1 SV=3 PF02367//PF03613//PF00158//PF01926//PF07728//PF08477//PF00735//PF00004//PF03193//PF03266//PF00005//PF04548//PF00910//PF00493//PF05049//PF00448//PF02421 Threonylcarbamoyl adenosine biosynthesis protein TsaE//PTS system mannose/fructose/sorbose family IID component//Sigma-54 interaction domain//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//Septin//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//NTPase//ABC transporter//AIG1 family//RNA helicase//MCM2/3/5 family//Interferon-inducible GTPase (IIGP)//SRP54-type protein, GTPase domain//Ferrous iron transport protein B GO:0007264//GO:0002949//GO:0015684//GO:0006260//GO:0009401//GO:0006355//GO:0006614 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//ferrous iron transport//DNA replication//phosphoenolpyruvate-dependent sugar phosphotransferase system//regulation of transcription, DNA-templated//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0005525//GO:0003677//GO:0015093//GO:0003723//GO:0016887//GO:0008134//GO:0003924//GO:0098519//GO:0005524 RNA helicase activity//GTP binding//DNA binding//ferrous iron transmembrane transporter activity//RNA binding//ATPase activity//transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding GO:0016020//GO:0005667//GO:0016021 membrane//transcription factor complex//integral component of membrane -- -- Cluster-8309.19955 BF_2 64.50 0.73 3995 546674815 ERL86101.1 2193 1.3e-243 hypothetical protein D910_03515 [Dendroctonus ponderosae] 815800151 XM_012365304.1 53 6.25349e-16 PREDICTED: Linepithema humile uncharacterized LOC105671296 (LOC105671296), transcript variant X3, mRNA -- -- -- -- B0UYT5 156 8.7e-09 Major facilitator superfamily domain-containing protein 6-B OS=Danio rerio GN=mfsd6b PE=3 SV=1 PF07690//PF01306 Major Facilitator Superfamily//LacY proton/sugar symporter GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.19959 BF_2 118.61 1.53 3521 642932408 XP_008197099.1 1304 1.4e-140 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19961 BF_2 948.03 17.21 2591 642933047 XP_971594.2 2198 2.3e-244 PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum]>gi|642933049|ref|XP_008197242.1| PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum] -- -- -- -- -- K03372 ACATN, SLC33A1 MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA transportor), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03372 Q6AYY8 1412 1.3e-154 Acetyl-coenzyme A transporter 1 OS=Rattus norvegicus GN=Slc33a1 PE=2 SV=1 PF01776//PF13000//PF07690 Ribosomal L22e protein family//Acetyl-coenzyme A transporter 1//Major Facilitator Superfamily GO:0042254//GO:0006412//GO:0015876//GO:0055085 ribosome biogenesis//translation//acetyl-CoA transport//transmembrane transport GO:0003735//GO:0008521 structural constituent of ribosome//acetyl-CoA transporter activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG3574 Acetyl-CoA transporter Cluster-8309.19962 BF_2 21.08 1.01 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.19965 BF_2 155.91 14.56 735 642939323 XP_969087.2 570 3.8e-56 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 295 1.2e-25 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01588 Putative tRNA binding domain -- -- GO:0000049 tRNA binding -- -- KOG2241 tRNA-binding protein Cluster-8309.19966 BF_2 2.00 0.96 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19967 BF_2 95.08 0.59 7068 642938595 XP_008199857.1 3648 0.0e+00 PREDICTED: C2 domain-containing protein 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86YS7 2135 5.1e-238 C2 domain-containing protein 5 OS=Homo sapiens GN=C2CD5 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1031 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.19969 BF_2 74.00 3.82 1097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19971 BF_2 345.00 14.73 1267 91089519 XP_970680.1 1043 9.4e-111 PREDICTED: deoxyhypusine hydroxylase [Tribolium castaneum]>gi|270012585|gb|EFA09033.1| hypothetical protein TcasGA2_TC006746 [Tribolium castaneum] 161661018 EU247113.1 38 4.24364e-08 Lycosa singoriensis deoxyhypusine hydroxylase-like mRNA, complete sequence K06072 DOHH deoxyhypusine monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K06072 Q9V9U4 937 7.6e-100 Deoxyhypusine hydroxylase OS=Drosophila melanogaster GN=nero PE=2 SV=1 PF00745//PF01347//PF02985 Glutamyl-tRNAGlu reductase, dimerisation domain//Lipoprotein amino terminal region//HEAT repeat GO:0055114//GO:0033014//GO:0006869 oxidation-reduction process//tetrapyrrole biosynthetic process//lipid transport GO:0050661//GO:0008883//GO:0005319//GO:0005515 NADP binding//glutamyl-tRNA reductase activity//lipid transporter activity//protein binding -- -- KOG0567 HEAT repeat-containing protein Cluster-8309.19975 BF_2 5.20 0.63 632 514683686 XP_004989424.1 256 8.5e-20 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- Q96PE6 186 4.6e-13 Zinc finger imprinted 3 OS=Homo sapiens GN=ZIM3 PE=2 SV=1 PF02150//PF00569//PF13465//PF00096//PF01096 RNA polymerases M/15 Kd subunit//Zinc finger, ZZ type//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS) GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0008270//GO:0003676//GO:0003899//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.19983 BF_2 3.35 0.51 559 642928426 XP_971688.3 278 2.1e-22 PREDICTED: RRP15-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VFE6 134 4.3e-07 RRP15-like protein OS=Drosophila melanogaster GN=CG3817 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.19986 BF_2 176.00 2.36 3408 642921600 XP_969038.3 1586 2.7e-173 PREDICTED: probable ATP-dependent RNA helicase DDX28 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWT6 657 6.0e-67 Probable ATP-dependent RNA helicase DDX28 OS=Mus musculus GN=Ddx28 PE=2 SV=2 PF07178//PF01176//PF00270//PF00176//PF04851 TraL protein//Translation initiation factor 1A / IF-1//DEAD/DEAH box helicase//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0006413//GO:0000746//GO:0006446 translational initiation//conjugation//regulation of translational initiation GO:0003676//GO:0003723//GO:0005524//GO:0016787//GO:0003677//GO:0003743 nucleic acid binding//RNA binding//ATP binding//hydrolase activity//DNA binding//translation initiation factor activity GO:0005840//GO:0019867 ribosome//outer membrane -- -- Cluster-8309.19987 BF_2 5.00 0.55 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19988 BF_2 19.00 0.50 1871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.19989 BF_2 21.49 2.25 686 642929197 XP_008195731.1 1009 4.4e-107 PREDICTED: WD repeat-containing protein 7 isoform X1 [Tribolium castaneum]>gi|642929199|ref|XP_008195732.1| PREDICTED: WD repeat-containing protein 7 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y4E6 436 5.1e-42 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG4155 FOG: WD40 repeat Cluster-8309.20005 BF_2 45.97 1.37 1691 642935403 XP_008197996.1 881 7.6e-92 PREDICTED: tumor protein p63-regulated gene 1-like protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0D9 347 2.6e-31 Tumor protein p63-regulated gene 1-like protein OS=Homo sapiens GN=TPRG1L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20007 BF_2 9.28 0.33 1482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20012 BF_2 20.00 1.03 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20015 BF_2 38.00 0.49 3502 768432767 XP_011557722.1 148 1.6e-06 PREDICTED: uncharacterized protein LOC105388496 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20017 BF_2 44.45 1.24 1783 91092400 XP_969218.1 763 3.9e-78 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 360 8.6e-33 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400//PF03875 WD domain, G-beta repeat//Statherin GO:0042742//GO:0030500 defense response to bacterium//regulation of bone mineralization GO:0046848//GO:0005515 hydroxyapatite binding//protein binding GO:0005576 extracellular region KOG2919 Guanine nucleotide-binding protein Cluster-8309.20019 BF_2 90.34 0.74 5391 642935536 XP_008198049.1 1893 1.1e-208 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X3 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q14642 962 4.1e-102 Type I inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens GN=INPP5A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1976 Inositol polyphosphate 5-phosphatase, type I Cluster-8309.20020 BF_2 357.67 3.64 4396 478259502 ENN79383.1 5149 0.0e+00 hypothetical protein YQE_04170, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H9JIQ1 3946 0.0e+00 Protein mesh OS=Bombyx mori PE=1 SV=1 PF06119//PF00779//PF01833 Nidogen-like//BTK motif//IPT/TIG domain GO:0007160//GO:0035556 cell-matrix adhesion//intracellular signal transduction GO:0005515 protein binding -- -- KOG4291 Mucin/alpha-tectorin Cluster-8309.20021 BF_2 8.00 0.70 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20022 BF_2 3.00 0.81 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20029 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2003 BF_2 2.00 0.63 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20030 BF_2 55.96 0.72 3561 270000870 EEZ97317.1 1789 8.3e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.50049e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.6e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.20033 BF_2 1.00 1.70 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20034 BF_2 4.00 0.34 779 -- -- -- -- -- 755883692 XM_011295486.1 41 5.51733e-10 PREDICTED: Musca domestica cytoplasmic dynein 1 intermediate chain (LOC101888373), transcript variant X15, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20036 BF_2 23.05 0.91 1346 270003908 EFA00356.1 1025 1.2e-108 hypothetical protein TcasGA2_TC003198 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 630 3.2e-64 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF03494//PF00583//PF13508//PF05301//PF13673 Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Acetyltransferase (GNAT) domain GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0019799//GO:0008080 tubulin N-acetyltransferase activity//N-acetyltransferase activity GO:0016021//GO:0005874//GO:0045298 integral component of membrane//microtubule//tubulin complex KOG4601 Uncharacterized conserved protein Cluster-8309.20039 BF_2 1.00 9.01 236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20041 BF_2 33.00 7.58 469 91079766 XP_966799.1 270 1.5e-21 PREDICTED: protein claret segregational [Tribolium castaneum]>gi|270003319|gb|EEZ99766.1| hypothetical protein TcasGA2_TC002539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BPU3 160 3.5e-10 Kinesin-related protein 2 OS=Dictyostelium discoideum GN=kif2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0239 Kinesin (KAR3 subfamily) Cluster-8309.20042 BF_2 48.76 0.82 2768 642928421 XP_008193780.1 3184 0.0e+00 PREDICTED: probable cleavage and polyadenylation specificity factor subunit 2 [Tribolium castaneum]>gi|270010824|gb|EFA07272.1| hypothetical protein TcasGA2_TC014506 [Tribolium castaneum] 665813545 XM_008557111.1 256 6.13677e-129 PREDICTED: Microplitis demolitor probable cleavage and polyadenylation specificity factor subunit 2 (LOC103576746), mRNA K14402 CPSF2, CFT2 cleavage and polyadenylation specificity factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14402 Q9V3D6 2508 1.1e-281 Probable cleavage and polyadenylation specificity factor subunit 2 OS=Drosophila melanogaster GN=Cpsf100 PE=1 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) Cluster-8309.20043 BF_2 30.20 0.98 1572 548544410 XP_005753889.1 472 1.9e-44 PREDICTED: zinc finger protein 84-like [Pundamilia nyererei] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 434 2.0e-41 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13465//PF00096//PF07776//PF13912//PF02892//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.20045 BF_2 179.62 2.28 3586 861617776 KMQ86664.1 685 8.7e-69 transposase [Lasius niger] 795025225 XM_012006147.1 47 1.2138e-12 PREDICTED: Vollenhovia emeryi uncharacterized LOC105558450 (LOC105558450), mRNA K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q8I7P9 304 5.4e-26 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF01498//PF01529//PF08281//PF12844//PF00665//PF04545//PF13683//PF13443 Transposase//DHHC palmitoyltransferase//Sigma-70, region 4//Helix-turn-helix domain//Integrase core domain//Sigma-70, region 4//Integrase core domain//Cro/C1-type HTH DNA-binding domain GO:0006313//GO:0006355//GO:0006352//GO:0015074 transposition, DNA-mediated//regulation of transcription, DNA-templated//DNA-templated transcription, initiation//DNA integration GO:0003677//GO:0008270//GO:0043565//GO:0016987//GO:0003700 DNA binding//zinc ion binding//sequence-specific DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.20046 BF_2 30.70 0.38 3644 102939 493 1.6e-46 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- Q8I7P9 304 5.5e-26 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF06056//PF02796//PF13545//PF04545//PF00665//PF13683//PF13404//PF01381//PF12844//PF01498//PF01529//PF01316//PF08281 Putative ATPase subunit of terminase (gpP-like)//Helix-turn-helix domain of resolvase//Crp-like helix-turn-helix domain//Sigma-70, region 4//Integrase core domain//Integrase core domain//AsnC-type helix-turn-helix domain//Helix-turn-helix//Helix-turn-helix domain//Transposase//DHHC palmitoyltransferase//Arginine repressor, DNA binding domain//Sigma-70, region 4 GO:0015074//GO:0006352//GO:0019069//GO:0006310//GO:0006355//GO:0006313//GO:0006525 DNA integration//DNA-templated transcription, initiation//viral capsid assembly//DNA recombination//regulation of transcription, DNA-templated//transposition, DNA-mediated//arginine metabolic process GO:0003700//GO:0016987//GO:0043565//GO:0008270//GO:0000150//GO:0003677//GO:0005524 transcription factor activity, sequence-specific DNA binding//sigma factor activity//sequence-specific DNA binding//zinc ion binding//recombinase activity//DNA binding//ATP binding GO:0005667 transcription factor complex -- -- Cluster-8309.20047 BF_2 19.67 0.32 2846 102939 493 1.3e-46 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- Q8I7P9 304 4.3e-26 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665//PF01529 Integrase core domain//Integrase core domain//DHHC palmitoyltransferase GO:0015074 DNA integration GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.20048 BF_2 160.00 1.12 6283 827552693 XP_012548103.1 1104 3.9e-117 PREDICTED: uncharacterized protein LOC105842033 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q8N328 396 2.0e-36 PiggyBac transposable element-derived protein 3 OS=Homo sapiens GN=PGBD3 PE=2 SV=3 PF05225//PF03184//PF01061//PF14822//PF01245 helix-turn-helix, Psq domain//DDE superfamily endonuclease//ABC-2 type transporter//Vasohibin//Ribosomal protein L19 GO:0042254//GO:0045765//GO:0006412 ribosome biogenesis//regulation of angiogenesis//translation GO:0003676//GO:0003735//GO:0003677 nucleic acid binding//structural constituent of ribosome//DNA binding GO:0005737//GO:0016020//GO:0005622//GO:0005840 cytoplasm//membrane//intracellular//ribosome -- -- Cluster-8309.20049 BF_2 3.00 0.89 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20051 BF_2 2.00 0.99 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20053 BF_2 939.75 56.50 983 91082325 XP_974590.1 318 8.5e-27 PREDICTED: epididymal secretory protein E1 [Tribolium castaneum]>gi|270008209|gb|EFA04657.1| hypothetical protein TcasGA2_TC014069 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20054 BF_2 78.00 6.30 805 332377007 AEE63643.1 551 6.7e-54 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 259 2.0e-21 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0006446//GO:0007423//GO:0006413 regulation of translational initiation//sensory organ development//translational initiation GO:0005212//GO:0003743 structural constituent of eye lens//translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.20055 BF_2 24.00 3.05 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20058 BF_2 86.08 2.80 1571 642912679 XP_969682.2 1119 1.8e-119 PREDICTED: geranylgeranyl transferase type-1 subunit beta [Tribolium castaneum] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 Q5EAD5 703 1.3e-72 Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus GN=PGGT1B PE=2 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0367 Protein geranylgeranyltransferase Type I, beta subunit Cluster-8309.20059 BF_2 21.21 0.58 1816 478252231 ENN72659.1 1051 1.6e-111 hypothetical protein YQE_10757, partial [Dendroctonus ponderosae]>gi|546675747|gb|ERL86879.1| hypothetical protein D910_04282 [Dendroctonus ponderosae] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 Q5EAD5 680 6.8e-70 Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus GN=PGGT1B PE=2 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0367 Protein geranylgeranyltransferase Type I, beta subunit Cluster-8309.20060 BF_2 155.33 4.85 1626 642912679 XP_969682.2 1119 1.9e-119 PREDICTED: geranylgeranyl transferase type-1 subunit beta [Tribolium castaneum] -- -- -- -- -- K11713 PGTB1 geranylgeranyl transferase type-1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K11713 Q5EAD5 703 1.3e-72 Geranylgeranyl transferase type-1 subunit beta OS=Bos taurus GN=PGGT1B PE=2 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat -- -- GO:0003824 catalytic activity -- -- KOG0367 Protein geranylgeranyltransferase Type I, beta subunit Cluster-8309.20062 BF_2 5.00 0.43 774 478252126 ENN72557.1 389 3.9e-35 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19096 128 3.0e-06 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.20068 BF_2 18.00 1.08 982 478253705 ENN74004.1 313 3.2e-26 hypothetical protein YQE_09394, partial [Dendroctonus ponderosae]>gi|546678194|gb|ERL88884.1| hypothetical protein D910_06266 [Dendroctonus ponderosae] -- -- -- -- -- K09622 KLK14 kallikrein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09622 Q00871 214 4.0e-16 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF03119//PF00089 NAD-dependent DNA ligase C4 zinc finger domain//Trypsin GO:0006281//GO:0006260//GO:0006508 DNA repair//DNA replication//proteolysis GO:0004252//GO:0003911 serine-type endopeptidase activity//DNA ligase (NAD+) activity -- -- -- -- Cluster-8309.20070 BF_2 41.80 3.36 807 91081763 XP_973188.1 230 1.1e-16 PREDICTED: UDP-glucuronosyltransferase 2B20 [Tribolium castaneum]>gi|270005052|gb|EFA01500.1| hypothetical protein TcasGA2_TC007056 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q6UWM9 175 1.1e-11 UDP-glucuronosyltransferase 2A3 OS=Homo sapiens GN=UGT2A3 PE=2 SV=2 -- -- -- -- GO:0016740 transferase activity -- -- -- -- Cluster-8309.20072 BF_2 24.35 0.53 2219 291170320 ADD82416.1 191 1.0e-11 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170321 GU584934.1 111 1.97653e-48 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20073 BF_2 180.00 7.38 1307 642928984 XP_008195645.1 681 9.2e-69 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 506 7.4e-50 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0016787 hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.20075 BF_2 47.12 0.79 2771 270003816 EFA00264.1 166 1.0e-08 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225 helix-turn-helix, Psq domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.20077 BF_2 1.00 0.46 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20078 BF_2 33.80 0.58 2708 642921567 XP_008192427.1 2882 0.0e+00 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1457 8.1e-160 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13374//PF00515//PF02891//PF03854//PF06464//PF13176//PF00637//PF13181 Tetratricopeptide repeat//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//P-11 zinc finger//DMAP1-binding Domain//Tetratricopeptide repeat//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0005515//GO:0008134//GO:0003723 zinc ion binding//protein binding//transcription factor binding//RNA binding GO:0005622//GO:0005667//GO:0005634 intracellular//transcription factor complex//nucleus KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.20079 BF_2 257.00 4.84 2508 91087967 XP_973079.1 1853 2.2e-204 PREDICTED: U3 small nucleolar RNA-associated protein 14 homolog A [Tribolium castaneum]>gi|270012047|gb|EFA08495.1| hypothetical protein TcasGA2_TC006147 [Tribolium castaneum] -- -- -- -- -- K14567 UTP14 U3 small nucleolar RNA-associated protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K14567 Q9BVJ6 522 2.0e-51 U3 small nucleolar RNA-associated protein 14 homolog A OS=Homo sapiens GN=UTP14A PE=1 SV=1 PF04615 Utp14 protein GO:0006364 rRNA processing -- -- GO:0032040 small-subunit processome KOG2172 Uncharacterized conserved protein Cluster-8309.20081 BF_2 3.00 7.56 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02202 Tachykinin family GO:0007217//GO:0007268 tachykinin receptor signaling pathway//synaptic transmission -- -- -- -- -- -- Cluster-8309.20082 BF_2 1653.00 61.75 1407 189236685 XP_001813143.1 1291 1.8e-139 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005168|gb|EFA01616.1| hypothetical protein TcasGA2_TC007185 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 796 1.9e-83 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.20083 BF_2 21.77 1.36 957 270004868 EFA01316.1 280 2.1e-22 hypothetical protein TcasGA2_TC003278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55918 226 1.6e-17 Microfibril-associated glycoprotein 4 OS=Bos taurus GN=MFAP4 PE=1 SV=2 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.20086 BF_2 699.00 20.78 1694 270005908 EFA02356.1 1594 1.6e-174 hypothetical protein TcasGA2_TC008028 [Tribolium castaneum] -- -- -- -- -- K00453 E1.13.11.11, TDO2 tryptophan 2,3-dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00453 Q95NN1 1592 1.1e-175 Tryptophan 2,3-dioxygenase OS=Tribolium castaneum PE=2 SV=1 PF03301//PF10391 Tryptophan 2,3-dioxygenase//Fingers domain of DNA polymerase lambda GO:0006568//GO:0019441 tryptophan metabolic process//tryptophan catabolic process to kynurenine GO:0034061//GO:0020037//GO:0004833//GO:0003677 DNA polymerase activity//heme binding//tryptophan 2,3-dioxygenase activity//DNA binding GO:0005634 nucleus KOG3906 Tryptophan 2,3-dioxygenase Cluster-8309.20090 BF_2 26.00 0.37 3263 270008711 EFA05159.1 262 8.8e-20 hypothetical protein TcasGA2_TC015278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02660//PF00847//PF02949 Glycerol-3-phosphate acyltransferase//AP2 domain//7tm Odorant receptor GO:0008654//GO:0007608//GO:0006355//GO:0007187 phospholipid biosynthetic process//sensory perception of smell//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0003700//GO:0004984//GO:0043772//GO:0005549 transcription factor activity, sequence-specific DNA binding//olfactory receptor activity//acyl-phosphate glycerol-3-phosphate acyltransferase activity//odorant binding GO:0016020//GO:0005667//GO:0005886 membrane//transcription factor complex//plasma membrane -- -- Cluster-8309.20092 BF_2 9.37 1.68 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20095 BF_2 9.00 1.86 489 270013391 EFA09839.1 835 4.8e-87 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82279 147 1.2e-08 Protein crumbs homolog 1 OS=Homo sapiens GN=CRB1 PE=1 SV=2 PF01073//PF00008 3-beta hydroxysteroid dehydrogenase/isomerase family//EGF-like domain GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//estrogen metabolic process GO:0003854//GO:0016616//GO:0005515 3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.20096 BF_2 24.00 3.07 614 270013391 EFA09839.1 863 3.4e-90 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 144 3.3e-08 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.20097 BF_2 78.85 0.87 4060 642913640 XP_008201099.1 2674 2.3e-299 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum]>gi|642913648|ref|XP_008201103.1| PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 3.5e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.20103 BF_2 15.48 0.54 1493 91093365 XP_969666.1 1912 1.9e-211 PREDICTED: nedd8-activating enzyme E1 catalytic subunit [Tribolium castaneum]>gi|270015296|gb|EFA11744.1| hypothetical protein TcasGA2_TC004234 [Tribolium castaneum] -- -- -- -- -- K10686 UBE1C, UBA3 ubiquitin-activating enzyme E1 C http://www.genome.jp/dbget-bin/www_bget?ko:K10686 Q7ZVX6 1579 3.2e-174 NEDD8-activating enzyme E1 catalytic subunit OS=Danio rerio GN=uba3 PE=2 SV=1 PF00070//PF00899//PF08825 Pyridine nucleotide-disulphide oxidoreductase//ThiF family//E2 binding domain GO:0045116//GO:0055114 protein neddylation//oxidation-reduction process GO:0016881//GO:0005524//GO:0016491//GO:0008641 acid-amino acid ligase activity//ATP binding//oxidoreductase activity//small protein activating enzyme activity -- -- KOG2015 NEDD8-activating complex, catalytic component UBA3 Cluster-8309.20105 BF_2 559.06 19.57 1482 642913141 XP_008201410.1 1534 1.3e-167 PREDICTED: C-5 sterol desaturase erg31-like [Tribolium castaneum] -- -- -- -- -- K00227 SC5DL, ERG3 delta7-sterol 5-desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K00227 Q7SBB6 242 3.4e-19 Probable C-5 sterol desaturase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=NCU06207 PE=3 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- -- -- Cluster-8309.20106 BF_2 50.00 1.27 1928 227018324 ACP18828.1 779 5.9e-80 chitin deacetylase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20107 BF_2 449.00 67.35 566 227018324 ACP18828.1 419 9.5e-39 chitin deacetylase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01522 Polysaccharide deacetylase GO:0005975//GO:0006807 carbohydrate metabolic process//nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.2011 BF_2 17.00 0.31 2579 768032055 AJT60335.1 2842 0.0e+00 nuclear hormone receptor E75 [Portunus trituberculatus] 768032054 KM016226.1 1960 0 Portunus trituberculatus nuclear hormone receptor E75 mRNA, complete cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 O77245 1625 2.6e-179 Nuclear hormone receptor E75 OS=Metapenaeus ensis GN=E75 PE=2 SV=1 PF00104 Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.20113 BF_2 2.00 3.05 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20120 BF_2 55.09 0.70 3591 91090862 XP_972769.1 1041 4.5e-110 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 98 5.42019e-41 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 Q6PC30 885 2.3e-93 COP9 signalosome complex subunit 5 OS=Danio rerio GN=cops5 PE=2 SV=1 PF01040//PF03083//PF01398 UbiA prenyltransferase family//Sugar efflux transporter for intercellular exchange//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0004659//GO:0005515 prenyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.20121 BF_2 51.50 0.56 4159 478263614 ENN81920.1 2036 2.2e-225 hypothetical protein YQE_01631, partial [Dendroctonus ponderosae] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 725 9.5e-75 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.20123 BF_2 77.04 0.87 4004 546679674 ERL90101.1 1875 9.9e-207 hypothetical protein D910_07455 [Dendroctonus ponderosae] 642934912 XM_008199638.1 468 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X3, mRNA K04496 CTBP C-terminal binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04496 O46036 1708 9.5e-189 C-terminal-binding protein OS=Drosophila melanogaster GN=CtBP PE=1 SV=3 PF03493//PF00389//PF02826//PF03446//PF16622 Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//zinc-finger C2H2-type GO:0006098//GO:0008152//GO:0006813//GO:0019521//GO:0055114 pentose-phosphate shunt//metabolic process//potassium ion transport//D-gluconate metabolic process//oxidation-reduction process GO:0016616//GO:0051287//GO:0015269//GO:0004616//GO:0046872 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//calcium-activated potassium channel activity//phosphogluconate dehydrogenase (decarboxylating) activity//metal ion binding GO:0016020 membrane KOG0067 Transcription factor CtBP Cluster-8309.20124 BF_2 19.00 0.89 1182 821482408 XP_012404151.1 378 1.1e-33 PREDICTED: hydroperoxide isomerase ALOXE3 isoform X2 [Sarcophilus harrisii] 14589308 AJ309069.1 393 0 Sesbania rostrata mRNA for lipoxygenase K18684 ALOXE3 hydroperoxy icosatetraenoate dehydratase/isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K18684 O24371 1531 9.3e-169 Linoleate 13S-lipoxygenase 3-1, chloroplastic OS=Solanum tuberosum GN=LOX3.1 PE=1 SV=1 PF00305//PF03533 Lipoxygenase//SPO11 homologue GO:0007131//GO:0055114 reciprocal meiotic recombination//oxidation-reduction process GO:0003677//GO:0046872//GO:0016702 DNA binding//metal ion binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen -- -- -- -- Cluster-8309.20126 BF_2 371.48 2.59 6276 373159261 AEY63780.1 2465 6.0e-275 ecdysone receptor isoform A [Monochamus alternatus] 373159260 JN616374.1 1387 0 Monochamus alternatus ecdysone receptor isoform A mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1354 1.7e-147 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.20127 BF_2 126.00 25.71 492 642925502 XP_008194577.1 360 5.7e-32 PREDICTED: immediate early response 3-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3B8G7 240 1.9e-19 Immediate early response 3-interacting protein 1 OS=Xenopus laevis GN=ier3ip1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4779 Predicted membrane protein Cluster-8309.20128 BF_2 48.00 1.29 1847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20129 BF_2 53.35 1.19 2155 642919337 XP_008191830.1 622 1.1e-61 PREDICTED: protein atonal homolog 7-like [Tribolium castaneum]>gi|270005529|gb|EFA01977.1| hypothetical protein TcasGA2_TC007598 [Tribolium castaneum] -- -- -- -- -- K09104 K09104 bHLH factor, other http://www.genome.jp/dbget-bin/www_bget?ko:K09104 P41894 264 1.4e-21 Helix-loop-helix protein delilah OS=Drosophila melanogaster GN=tx PE=1 SV=3 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3898 Transcription factor NeuroD and related HTH proteins Cluster-8309.2013 BF_2 2.00 1.92 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20130 BF_2 1.00 2.32 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20131 BF_2 64.65 1.47 2124 642919337 XP_008191830.1 674 9.7e-68 PREDICTED: protein atonal homolog 7-like [Tribolium castaneum]>gi|270005529|gb|EFA01977.1| hypothetical protein TcasGA2_TC007598 [Tribolium castaneum] -- -- -- -- -- K09104 K09104 bHLH factor, other http://www.genome.jp/dbget-bin/www_bget?ko:K09104 P41894 264 1.4e-21 Helix-loop-helix protein delilah OS=Drosophila melanogaster GN=tx PE=1 SV=3 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3898 Transcription factor NeuroD and related HTH proteins Cluster-8309.20132 BF_2 98.15 1.51 3006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20135 BF_2 27.72 1.63 998 332373466 AEE61874.1 569 6.8e-56 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03539 RPP1, RPP30 ribonuclease P/MRP protein subunit RPP1 http://www.genome.jp/dbget-bin/www_bget?ko:K03539 P78346 231 4.4e-18 Ribonuclease P protein subunit p30 OS=Homo sapiens GN=RPP30 PE=1 SV=1 PF01876 RNase P subunit p30 GO:0008033//GO:0051252 tRNA processing//regulation of RNA metabolic process GO:0004540 ribonuclease activity -- -- KOG2363 Protein subunit of nuclear ribonuclease P (RNase P) Cluster-8309.20138 BF_2 35.00 2.27 932 546683574 ERL93372.1 644 1.3e-64 hypothetical protein D910_10664 [Dendroctonus ponderosae] 60300014 AY771359.1 411 0 Apriona germari chymotrypsin mRNA, complete sequence K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 Q00871 490 3.8e-48 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20139 BF_2 97.97 2.22 2133 642915726 XP_008190777.1 1386 2.7e-150 PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum]>gi|642915728|ref|XP_008190778.1| PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 Q9NWF9 442 3.2e-42 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF03119//PF02807//PF10044 NAD-dependent DNA ligase C4 zinc finger domain//ATP:guanido phosphotransferase, N-terminal domain//Retinal tissue protein GO:0006281//GO:0006351//GO:0007049//GO:0006260 DNA repair//transcription, DNA-templated//cell cycle//DNA replication GO:0003911//GO:0016772//GO:0016301 DNA ligase (NAD+) activity//transferase activity, transferring phosphorus-containing groups//kinase activity GO:0070176 DRM complex -- -- Cluster-8309.2014 BF_2 4.00 0.39 721 -- -- -- -- -- 768032054 KM016226.1 681 0 Portunus trituberculatus nuclear hormone receptor E75 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20140 BF_2 8.00 2.20 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20141 BF_2 811.00 177.57 478 332374188 AEE62235.1 222 5.6e-16 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09620 KLK11, PRSS20 kallikrein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09620 Q7SIG2 172 1.4e-11 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20142 BF_2 693.07 87.10 620 332374188 AEE62235.1 259 3.7e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01311 CTRC chymotrypsin C http://www.genome.jp/dbget-bin/www_bget?ko:K01311 P36178 224 1.8e-17 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20144 BF_2 15.10 0.91 979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20146 BF_2 278.94 28.20 701 53830039 AAU94927.1 408 2.2e-37 larval cuticle protein 8.7 [Apriona germari] 53830038 AY769984.1 294 1.12661e-150 Apriona germari larval cuticle protein 8.7 mRNA, complete cds -- -- -- -- Q7M4E8 229 5.2e-18 Endocuticle structural protein SgAbd-6 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.20149 BF_2 69.97 0.72 4326 642911033 XP_008193517.1 2777 3.4e-311 PREDICTED: small conductance calcium-activated potassium channel protein [Tribolium castaneum] 642911032 XM_008195295.1 710 0 PREDICTED: Tribolium castaneum small conductance calcium-activated potassium channel protein (LOC657962), mRNA K05325 KCNNN potassium intermediate/small conductance calcium-activated channel subfamily N, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05325 Q7KVW5 2299 3.0e-257 Small conductance calcium-activated potassium channel protein OS=Drosophila melanogaster GN=SK PE=2 SV=2 PF03530//PF01407//PF01544//PF03119//PF02888//PF00520 Calcium-activated SK potassium channel//Geminivirus AL3 protein//CorA-like Mg2+ transporter protein//NAD-dependent DNA ligase C4 zinc finger domain//Calmodulin binding domain//Ion transport protein GO:0006813//GO:0006281//GO:0030001//GO:0055085//GO:0016032//GO:0006811//GO:0006260 potassium ion transport//DNA repair//metal ion transport//transmembrane transport//viral process//ion transport//DNA replication GO:0016286//GO:0015269//GO:0005516//GO:0003911//GO:0005216//GO:0046873 small conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity//calmodulin binding//DNA ligase (NAD+) activity//ion channel activity//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3684 Ca2+-activated K+ channel proteins (intermediate/small conductance classes) Cluster-8309.2015 BF_2 2.00 0.41 491 -- -- -- -- -- 462348779 APGK01033495.1 39 4.38903e-09 Dendroctonus ponderosae Seq01033505, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20151 BF_2 86.00 1.92 2157 759150859 XP_011369067.1 293 1.5e-23 PREDICTED: ALK tyrosine kinase receptor [Pteropus vampyrus] 221554531 NG_009445.1 2151 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 293 6.1e-25 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF06766 Fungal hydrophobin -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.20152 BF_2 13.00 1.42 669 460417247 CCQ42786.1 762 1.9e-78 aldolase homolog B [Leucosolenia complicata] 359751824 JN208224.1 669 0 Oryza sativa Japonica Group isolate Kcb949a11 fructose-bisphosphate aldolase mRNA, complete cds K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P17784 1106 1.0e-119 Fructose-bisphosphate aldolase cytoplasmic isozyme OS=Oryza sativa subsp. japonica GN=FBA PE=1 SV=2 PF00274 Fructose-bisphosphate aldolase class-I GO:0006096//GO:0006098//GO:0006020//GO:0006094//GO:0015976//GO:0006000//GO:0006013 glycolytic process//pentose-phosphate shunt//inositol metabolic process//gluconeogenesis//carbon utilization//fructose metabolic process//mannose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.20153 BF_2 220.17 13.69 960 642933131 XP_008197270.1 918 2.2e-96 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] 462326012 APGK01041603.1 84 8.5628e-34 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- Q8N4B1 379 2.9e-35 Sesquipedalian-1 OS=Homo sapiens GN=FAM109A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20158 BF_2 7.03 1.21 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20162 BF_2 5.00 0.62 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20165 BF_2 101.12 2.59 1920 642915433 XP_008190613.1 571 7.7e-56 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508//PF13302//PF13673//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.20166 BF_2 118.22 4.18 1470 642930675 XP_966843.2 1163 1.3e-124 PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 P08111 601 8.0e-61 Lethal(2) giant larvae protein OS=Drosophila melanogaster GN=l(2)gl PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.20168 BF_2 128.14 6.44 1119 642915266 XP_971845.3 865 3.6e-90 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- K17928 SNX16 sorting nexin-16 http://www.genome.jp/dbget-bin/www_bget?ko:K17928 P57768 338 1.9e-30 Sorting nexin-16 OS=Homo sapiens GN=SNX16 PE=1 SV=2 PF08702//PF00787 Fibrinogen alpha/beta chain family//PX domain GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0035091//GO:0005102//GO:0030674 phosphatidylinositol binding//receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.20169 BF_2 116.00 23.33 495 -- -- -- -- -- 193075297 EU559433.1 75 4.30383e-29 Paraliochthonius sp. JM-2008 voucher DNA102398 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20170 BF_2 44.98 0.75 2799 642921104 XP_008192691.1 1190 1.9e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.8e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678 Centriole duplication and mitotic chromosome congression GO:0090307 mitotic spindle assembly -- -- -- -- KOG2548 SWAP mRNA splicing regulator Cluster-8309.20171 BF_2 3.00 0.40 604 893567414 NP_001297599.1 234 2.9e-17 zinc finger protein 111 isoform 2 [Mus musculus]>gi|5640013|gb|AAD45927.1|AF167318_1 zinc finger protein ZFP111 [Mus musculus]>gi|148692404|gb|EDL24351.1| mCG22852 [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NK53 213 3.2e-16 Zinc finger protein 233 OS=Homo sapiens GN=ZNF233 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20173 BF_2 80.76 0.90 4030 546684811 ERL94393.1 1400 1.2e-151 hypothetical protein D910_11672, partial [Dendroctonus ponderosae] 195134144 XM_002011462.1 52 2.26904e-15 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q8CDK2 680 1.5e-69 Cytosolic carboxypeptidase 2 OS=Mus musculus GN=Agbl2 PE=1 SV=1 PF00246//PF04928//PF04952 Zinc carboxypeptidase//Poly(A) polymerase central domain//Succinylglutamate desuccinylase / Aspartoacylase family GO:0043631//GO:0006508//GO:0008152 RNA polyadenylation//proteolysis//metabolic process GO:0004652//GO:0008270//GO:0016788//GO:0004181 polynucleotide adenylyltransferase activity//zinc ion binding//hydrolase activity, acting on ester bonds//metallocarboxypeptidase activity -- -- KOG3641 Zinc carboxypeptidase Cluster-8309.20174 BF_2 14.81 0.37 1976 642914050 XP_008201524.1 1511 7.9e-165 PREDICTED: sorting nexin-6 isoform X1 [Tribolium castaneum] 697469095 XM_009669926.1 81 8.34804e-32 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 931 5.8e-99 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF01916//PF04632//PF00787 Deoxyhypusine synthase//Fusaric acid resistance protein family//PX domain GO:0006810//GO:0008612 transport//peptidyl-lysine modification to peptidyl-hypusine GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.20175 BF_2 169.99 2.25 3452 646705167 KDR13034.1 1480 5.4e-161 Myotubularin-related protein 14 [Zootermopsis nevadensis] -- -- -- -- -- K18086 MTMR14 myotubularin-related protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K18086 Q8NCE2 1050 1.6e-112 Myotubularin-related protein 14 OS=Homo sapiens GN=MTMR14 PE=1 SV=2 PF09788//PF00102 Transmembrane protein 55A//Protein-tyrosine phosphatase GO:0046856//GO:0006470//GO:0006570 phosphatidylinositol dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0034597//GO:0004725 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.20184 BF_2 61.00 3.57 1002 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20185 BF_2 34.66 0.44 3603 641649257 XP_008185321.1 466 2.2e-43 PREDICTED: uncharacterized protein LOC103310050 [Acyrthosiphon pisum] -- -- -- -- -- K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8CGZ0 259 8.9e-21 Calcium homeostasis endoplasmic reticulum protein OS=Mus musculus GN=Cherp PE=1 SV=1 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG4368 Predicted RNA binding protein, contains SWAP, RPR and G-patch domains Cluster-8309.20188 BF_2 80.44 0.43 8083 21755011 BAC04610.1 526 5.3e-50 unnamed protein product [Homo sapiens] 297723644 NM_001187257.1 43 4.60204e-10 Oryza sativa Japonica Group Os05g0117798 (Os05g0117798) mRNA, complete cds K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 A0JNB1 521 8.3e-51 Zinc finger protein 227 OS=Bos taurus GN=ZNF227 PE=2 SV=1 PF00096//PF07975//PF00225//PF01428//PF04810//PF13912//PF01155//PF05715//PF07776//PF06467//PF07649//PF06009//PF13465//PF16622//PF00412//PF02892 Zinc finger, C2H2 type//TFIIH C1-like domain//Kinesin motor domain//AN1-like Zinc finger//Sec23/Sec24 zinc finger//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Piccolo Zn-finger//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//C1-like domain//Laminin Domain II//Zinc-finger double domain//zinc-finger C2H2-type//LIM domain//BED zinc finger GO:0007155//GO:0006888//GO:0055114//GO:0007017//GO:0006886//GO:0006281//GO:0007018//GO:0006464 cell adhesion//ER to Golgi vesicle-mediated transport//oxidation-reduction process//microtubule-based process//intracellular protein transport//DNA repair//microtubule-based movement//cellular protein modification process GO:0046872//GO:0008017//GO:0003777//GO:0016151//GO:0003677//GO:0047134//GO:0008270//GO:0005524 metal ion binding//microtubule binding//microtubule motor activity//nickel cation binding//DNA binding//protein-disulfide reductase activity//zinc ion binding//ATP binding GO:0005874//GO:0005634//GO:0045202//GO:0045298//GO:0030127 microtubule//nucleus//synapse//tubulin complex//COPII vesicle coat -- -- Cluster-8309.20189 BF_2 202.04 4.39 2211 270014457 EFA10905.1 278 8.3e-22 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776 Zinc knuckle//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.2019 BF_2 11.00 0.57 1099 642936483 XP_968389.2 639 5.7e-64 PREDICTED: probable DNA replication complex GINS protein PSF2 [Tribolium castaneum] -- -- -- -- -- K10733 GINS2, PSF2 GINS complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10733 Q9VQY9 542 4.2e-54 Probable DNA replication complex GINS protein PSF2 OS=Drosophila melanogaster GN=Psf2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4071 Uncharacterized conserved protein Cluster-8309.20192 BF_2 571.00 18.11 1606 91076488 XP_972738.1 1383 4.5e-150 PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Tribolium castaneum]>gi|642912536|ref|XP_008200903.1| PREDICTED: activator of 90 kDa heat shock protein ATPase homolog 1 [Tribolium castaneum]>gi|270002597|gb|EEZ99044.1| hypothetical protein TcasGA2_TC004918 [Tribolium castaneum] 572315610 XM_006623391.1 101 5.14987e-43 PREDICTED: Apis dorsata activator of 90 kDa heat shock protein ATPase homolog 1-like (LOC102679971), mRNA -- -- -- -- Q8BK64 812 3.0e-85 Activator of 90 kDa heat shock protein ATPase homolog 1 OS=Mus musculus GN=Ahsa1 PE=2 SV=2 PF08327//PF09229 Activator of Hsp90 ATPase homolog 1-like protein//Activator of Hsp90 ATPase, N-terminal GO:0006950//GO:0032781 response to stress//positive regulation of ATPase activity GO:0051087//GO:0001671 chaperone binding//ATPase activator activity -- -- KOG2936 Uncharacterized conserved protein Cluster-8309.20197 BF_2 162.53 4.56 1778 91093821 XP_969004.1 1000 1.3e-105 PREDICTED: UDP-glucuronosyltransferase 2B9 [Tribolium castaneum]>gi|270015903|gb|EFA12351.1| hypothetical protein TcasGA2_TC002056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GLD9 525 6.3e-52 UDP-glucuronosyltransferase 2B33 OS=Macaca mulatta GN=UGT2B33 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.20198 BF_2 17.56 0.48 1804 91093821 XP_969004.1 656 1.0e-65 PREDICTED: UDP-glucuronosyltransferase 2B9 [Tribolium castaneum]>gi|270015903|gb|EFA12351.1| hypothetical protein TcasGA2_TC002056 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O60656 306 1.6e-26 UDP-glucuronosyltransferase 1-9 OS=Homo sapiens GN=UGT1A9 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.20199 BF_2 787.00 65.87 787 748995286 AJE75665.1 881 3.6e-92 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 674 1.5e-69 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.20200 BF_2 54.49 2.24 1306 -- -- -- -- -- 642938592 XM_008201634.1 158 8.58303e-75 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X9, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20201 BF_2 37.98 0.54 3242 642937773 XP_008198939.1 1921 3.7e-212 PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Tribolium castaneum]>gi|270000767|gb|EEZ97214.1| hypothetical protein TcasGA2_TC011007 [Tribolium castaneum] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 Q8TF62 1173 8.3e-127 Probable phospholipid-transporting ATPase IM OS=Homo sapiens GN=ATP8B4 PE=1 SV=3 -- -- GO:0015914//GO:0015917//GO:0006812 phospholipid transport//aminophospholipid transport//cation transport GO:0004012//GO:0015662//GO:0005524//GO:0000287 phospholipid-translocating ATPase activity//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//ATP binding//magnesium ion binding GO:0016021 integral component of membrane KOG0206 P-type ATPase Cluster-8309.20202 BF_2 72.68 1.01 3308 478252419 ENN72843.1 1917 1.1e-211 hypothetical protein YQE_10523, partial [Dendroctonus ponderosae]>gi|546677841|gb|ERL88598.1| hypothetical protein D910_05983, partial [Dendroctonus ponderosae] -- -- -- -- -- K18419 DCGR8 microprocessor complex subunit DGCR8 http://www.genome.jp/dbget-bin/www_bget?ko:K18419 A6QR44 819 9.5e-86 Microprocessor complex subunit DGCR8 OS=Bos taurus GN=DGCR8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4334 Uncharacterized conserved protein, contains double-stranded RNA-binding motif and WW domain Cluster-8309.20203 BF_2 22.00 0.83 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20205 BF_2 107.00 7.28 902 443711904 ELU05451.1 255 1.6e-19 hypothetical protein CAPTEDRAFT_61389, partial [Capitella teleta] 19919546 AF479105.1 650 0 Juglans nigra 26S ribosomal RNA gene, complete sequence -- -- -- -- Q6CQE5 131 1.6e-06 Protein TAR1 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=TAR1-A PE=4 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20207 BF_2 258.56 7.98 1643 748995290 AJE75667.1 1668 4.1e-183 putative glycosyl hydrolase [Chrysomela lapponica] 642928983 XM_008197423.1 57 1.51835e-18 PREDICTED: Tribolium castaneum myrosinase 1 (LOC661165), mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1205 8.2e-131 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00150//PF00232 Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.2021 BF_2 3.00 0.36 631 545487328 XP_533590.3 938 7.0e-99 PREDICTED: 40S ribosomal protein S9 [Canis lupus familiaris] 45786139 BC068055.1 597 0 Homo sapiens ribosomal protein S9, mRNA (cDNA clone MGC:78492 IMAGE:5454636), complete cds K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 A6QLG5 928 4.1e-99 40S ribosomal protein S9 OS=Bos taurus GN=RPS9 PE=2 SV=1 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain -- -- GO:0019843//GO:0003723 rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.20215 BF_2 193.12 74.61 394 157112848 XP_001657644.1 266 3.6e-21 AAEL006305-PA, partial [Aedes aegypti]>gi|108877923|gb|EAT42148.1| AAEL006305-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- P11414 140 6.1e-08 DNA-directed RNA polymerase II subunit RPB1 (Fragment) OS=Cricetulus griseus GN=POLR2A PE=3 SV=1 PF05109 Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle -- -- GO:0019031 viral envelope KOG0260 RNA polymerase II, large subunit Cluster-8309.20217 BF_2 191.96 2.54 3451 478263614 ENN81920.1 2165 2.0e-240 hypothetical protein YQE_01631, partial [Dendroctonus ponderosae] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 766 1.4e-79 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.20218 BF_2 20.00 1.59 814 144952784 ABP04046.1 242 4.6e-18 glutathione peroxidase-like protein [Crassostrea ariakensis] 731404355 XM_002274733.2 331 3.56087e-171 PREDICTED: Vitis vinifera peroxidase 42-like (LOC100241814), mRNA -- -- -- -- Q9SB81 778 1.3e-81 Peroxidase 42 OS=Arabidopsis thaliana GN=PER42 PE=1 SV=2 PF00141 Peroxidase GO:0006979//GO:0006804//GO:0055114 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- -- -- Cluster-8309.20219 BF_2 2387.00 264.96 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20224 BF_2 251.03 2.53 4444 642922938 XP_008200459.1 3758 0.0e+00 PREDICTED: symplekin [Tribolium castaneum]>gi|270006545|gb|EFA02993.1| hypothetical protein TcasGA2_TC010414 [Tribolium castaneum] -- -- -- -- -- K06100 SYMPK symplekin http://www.genome.jp/dbget-bin/www_bget?ko:K06100 Q8MSU4 1770 6.8e-196 Symplekin OS=Drosophila melanogaster GN=Sym PE=1 SV=1 PF10392//PF00312//PF04111//PF14764 Golgi transport complex subunit 5//Ribosomal protein S15//Autophagy protein Apg6//AP-5 complex subunit, vesicle trafficking GO:0006891//GO:0006412//GO:0006914//GO:0042254 intra-Golgi vesicle-mediated transport//translation//autophagy//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0044599//GO:0005622//GO:0017119//GO:0005840 AP-5 adaptor complex//intracellular//Golgi transport complex//ribosome KOG1895 mRNA cleavage and polyadenylation factor II complex, subunit PTA1 Cluster-8309.20227 BF_2 336.70 13.31 1345 270013786 EFA10234.1 357 3.5e-31 hypothetical protein TcasGA2_TC012431 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20228 BF_2 15.86 0.34 2243 478250620 ENN71112.1 1013 5.0e-107 hypothetical protein YQE_12045, partial [Dendroctonus ponderosae] -- -- -- -- -- K17583 NOM1 nucleolar MIF4G domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17583 Q9W020 655 6.7e-67 Nucleolar MIF4G domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG9004 PE=2 SV=1 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2141 Protein involved in high osmolarity signaling pathway Cluster-8309.2023 BF_2 8.00 0.57 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20230 BF_2 335.14 5.41 2877 478250620 ENN71112.1 1970 6.9e-218 hypothetical protein YQE_12045, partial [Dendroctonus ponderosae] -- -- -- -- -- K17583 NOM1 nucleolar MIF4G domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17583 Q9W020 1263 2.7e-137 Nucleolar MIF4G domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG9004 PE=2 SV=1 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2141 Protein involved in high osmolarity signaling pathway Cluster-8309.20231 BF_2 313.99 3.40 4154 478253799 ENN74091.1 4824 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 2726 8.9e-307 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.20234 BF_2 28.67 0.31 4185 642924249 XP_966647.3 1292 4.2e-139 PREDICTED: palmitoyltransferase ZDHHC18 [Tribolium castaneum] -- -- -- -- -- K16675 ZDHHC9_14_18 palmitoyltransferase ZDHHC9/14/18 http://www.genome.jp/dbget-bin/www_bget?ko:K16675 Q8BQQ1 1009 1.1e-107 Probable palmitoyltransferase ZDHHC14 OS=Mus musculus GN=Zdhhc14 PE=2 SV=1 PF05493//PF13520//PF02419//PF03699//PF01529 ATP synthase subunit H//Amino acid permease//PsbL protein//Uncharacterised protein family (UPF0182)//DHHC palmitoyltransferase GO:0003333//GO:0015992//GO:0015979//GO:0006865//GO:0015991 amino acid transmembrane transport//proton transport//photosynthesis//amino acid transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0008270//GO:0015171 hydrogen ion transmembrane transporter activity//zinc ion binding//amino acid transmembrane transporter activity GO:0016020//GO:0009539//GO:0009523//GO:0033179//GO:0016021 membrane//photosystem II reaction center//photosystem II//proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG1311 DHHC-type Zn-finger proteins Cluster-8309.20235 BF_2 345.00 10.89 1612 642933484 XP_973892.2 1487 3.9e-162 PREDICTED: soluble calcium-activated nucleotidase 1 [Tribolium castaneum] -- -- -- -- -- K12304 CANT1 soluble calcium-activated nucleotidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12304 Q8VCF1 809 6.7e-85 Soluble calcium-activated nucleotidase 1 OS=Mus musculus GN=Cant1 PE=2 SV=1 PF06079 Apyrase -- -- GO:0016462//GO:0005509 pyrophosphatase activity//calcium ion binding -- -- KOG4494 Cell surface ATP diphosphohydrolase Apyrase Cluster-8309.20238 BF_2 121.67 1.54 3597 3127936 CAA06690.1 1930 3.7e-213 nuclear receptor [Tenebrio molitor] -- -- -- -- -- K08544 NR2C2, TR4 testicular receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08544 P55094 913 1.3e-96 Nuclear receptor subfamily 2 group C member 2 OS=Rattus norvegicus GN=Nr2c2 PE=2 SV=1 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.20254 BF_2 10.00 1.16 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20255 BF_2 66.00 3.19 1154 189237999 XP_001812951.1 879 8.9e-92 PREDICTED: mediator of RNA polymerase II transcription subunit 20 [Tribolium castaneum]>gi|270006649|gb|EFA03097.1| hypothetical protein TcasGA2_TC013006 [Tribolium castaneum] -- -- -- -- -- K13528 MED20 mediator of RNA polymerase II transcription subunit 20 http://www.genome.jp/dbget-bin/www_bget?ko:K13528 Q17LR9 704 7.2e-73 Mediator of RNA polymerase II transcription subunit 20 OS=Aedes aegypti GN=MED20 PE=3 SV=1 PF08612 TATA-binding related factor (TRF) of subunit 20 of Mediator complex GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4309 Transcription mediator-related factor Cluster-8309.20260 BF_2 16.00 0.79 1134 91078316 XP_972782.1 831 3.2e-86 PREDICTED: probable methyltransferase BTM2 homolog [Tribolium castaneum]>gi|270003957|gb|EFA00405.1| hypothetical protein TcasGA2_TC003256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W138 616 1.1e-62 Probable methyltransferase BTM2 homolog OS=Drosophila melanogaster GN=CG3570 PE=2 SV=1 PF11968//PF08241 Putative methyltransferase (DUF3321)//Methyltransferase domain GO:0008152//GO:0006396//GO:0000154 metabolic process//RNA processing//rRNA modification GO:0016433//GO:0008168 rRNA (adenine) methyltransferase activity//methyltransferase activity -- -- -- -- Cluster-8309.20263 BF_2 236.00 8.36 1468 478256346 ENN76536.1 297 3.5e-24 hypothetical protein YQE_06987, partial [Dendroctonus ponderosae]>gi|546680776|gb|ERL90982.1| hypothetical protein D910_08324 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20267 BF_2 109.32 0.81 5947 91090340 XP_967097.1 1862 4.7e-205 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 807 4.2e-84 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728//PF02259 Glycosyl hydrolase family 20, catalytic domain//FAT domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//protein binding -- -- -- -- Cluster-8309.20277 BF_2 61.14 1.04 2744 642934573 XP_008197722.1 2031 5.5e-225 PREDICTED: uncharacterized protein LOC658962 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10314 FBXO39 F-box protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K10314 -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20278 BF_2 31.00 0.84 1824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20279 BF_2 191.87 3.13 2849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20280 BF_2 138.76 5.17 1409 189237225 XP_001810464.1 1004 3.5e-106 PREDICTED: inhibitor of growth protein 5 isoform X3 [Tribolium castaneum] 170041067 XM_001848247.1 126 5.70405e-57 Culex quinquefasciatus inhibitor of growth protein, ing4, mRNA K11346 ING4 inhibitor of growth protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11346 Q5ZKY4 692 2.2e-71 Inhibitor of growth protein 4 OS=Gallus gallus GN=ING4 PE=2 SV=1 PF06320//PF00103//PF00628 GCN5-like protein 1 (GCN5L1)//Somatotropin hormone family//PHD-finger GO:0007165 signal transduction GO:0005179//GO:0005515 hormone activity//protein binding GO:0031083//GO:0005576 BLOC-1 complex//extracellular region KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.20281 BF_2 8.00 0.61 833 795360291 XP_011785973.1 178 1.2e-10 PREDICTED: keratin, type II cytoskeletal 6A [Colobus angolensis palliatus] 33874151 BC014152.2 766 0 Homo sapiens keratin 6A, mRNA (cDNA clone MGC:20671 IMAGE:3639270), complete cds K07605 KRT2 type II keratin, basic http://www.genome.jp/dbget-bin/www_bget?ko:K07605 P02538 178 5.1e-12 Keratin, type II cytoskeletal 6A OS=Homo sapiens GN=KRT6A PE=1 SV=3 PF00038 Intermediate filament protein -- -- GO:0005198 structural molecule activity GO:0005882 intermediate filament -- -- Cluster-8309.20283 BF_2 39.61 0.35 5057 123478871 XP_001322596.1 198 3.6e-12 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121905445|gb|EAY10373.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 159 4.9e-09 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF04998//PF13606//PF00023 RNA polymerase Rpb1, domain 5//Ankyrin repeat//Ankyrin repeat GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005730 nucleolus -- -- Cluster-8309.20288 BF_2 9.00 0.84 733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20289 BF_2 9.00 0.48 1067 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20291 BF_2 14.72 0.38 1906 270015218 EFA11666.1 244 6.3e-18 hypothetical protein TcasGA2_TC008530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW3 162 8.4e-10 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF13855//PF08163 Leucine rich repeat//NUC194 domain GO:0006303//GO:0016310//GO:0009069 double-strand break repair via nonhomologous end joining//phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0003677//GO:0004677//GO:0005524 protein binding//DNA binding//DNA-dependent protein kinase activity//ATP binding GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0619 FOG: Leucine rich repeat Cluster-8309.20292 BF_2 25.00 0.40 2920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20297 BF_2 33.26 0.65 2425 478252547 ENN72962.1 1070 1.3e-113 hypothetical protein YQE_10414, partial [Dendroctonus ponderosae] -- -- -- -- -- K14590 CMTR2, FTSJD1, AFT cap2 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14590 Q8IYT2 699 5.7e-72 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 OS=Homo sapiens GN=CMTR2 PE=1 SV=2 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.20299 BF_2 4.63 0.55 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20300 BF_2 54.00 0.79 3149 546680521 ERL90781.1 1999 3.3e-221 hypothetical protein D910_08127 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9HCS5 983 8.7e-105 Band 4.1-like protein 4A OS=Homo sapiens GN=EPB41L4A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.20301 BF_2 53.60 0.78 3171 91089013 XP_968301.1 1751 1.9e-192 PREDICTED: RINT1-like protein [Tribolium castaneum]>gi|270011539|gb|EFA07987.1| hypothetical protein TcasGA2_TC005574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZ36 755 2.4e-78 RAD50-interacting protein 1 OS=Mus musculus GN=Rint1 PE=2 SV=2 PF06008//PF05384//PF04437//PF08702 Laminin Domain I//Sensor protein DegS//RINT-1 / TIP-1 family//Fibrinogen alpha/beta chain family GO:0045995//GO:0030168//GO:0030155//GO:0048193//GO:0051258//GO:0030334//GO:0007165 regulation of embryonic development//platelet activation//regulation of cell adhesion//Golgi vesicle transport//protein polymerization//regulation of cell migration//signal transduction GO:0016301//GO:0005102//GO:0030674 kinase activity//receptor binding//protein binding, bridging GO:0005577//GO:0005783 fibrinogen complex//endoplasmic reticulum -- -- Cluster-8309.20302 BF_2 31.00 0.70 2129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00812 Ephrin -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.20304 BF_2 127.18 4.69 1421 478254577 ENN74820.1 991 1.1e-104 hypothetical protein YQE_08593, partial [Dendroctonus ponderosae]>gi|546674802|gb|ERL86096.1| hypothetical protein D910_03510 [Dendroctonus ponderosae] -- -- -- -- -- K02357 tsf, TSFM elongation factor Ts http://www.genome.jp/dbget-bin/www_bget?ko:K02357 Q17PI0 810 4.5e-85 Elongation factor Ts, mitochondrial OS=Aedes aegypti GN=AAEL000331 PE=3 SV=1 PF01434//PF00889 Peptidase family M41//Elongation factor TS GO:0006508//GO:0006414//GO:0006448 proteolysis//translational elongation//regulation of translational elongation GO:0003746//GO:0004222//GO:0005524 translation elongation factor activity//metalloendopeptidase activity//ATP binding GO:0005622//GO:0005840 intracellular//ribosome KOG1071 Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt Cluster-8309.20305 BF_2 193.82 4.10 2264 478254577 ENN74820.1 1005 4.3e-106 hypothetical protein YQE_08593, partial [Dendroctonus ponderosae]>gi|546674802|gb|ERL86096.1| hypothetical protein D910_03510 [Dendroctonus ponderosae] -- -- -- -- -- K02357 tsf, TSFM elongation factor Ts http://www.genome.jp/dbget-bin/www_bget?ko:K02357 Q17PI0 810 7.2e-85 Elongation factor Ts, mitochondrial OS=Aedes aegypti GN=AAEL000331 PE=3 SV=1 PF01434//PF00889 Peptidase family M41//Elongation factor TS GO:0006414//GO:0006448//GO:0006508 translational elongation//regulation of translational elongation//proteolysis GO:0005524//GO:0004222//GO:0003746 ATP binding//metalloendopeptidase activity//translation elongation factor activity GO:0005622//GO:0005840 intracellular//ribosome KOG1071 Mitochondrial translation elongation factor EF-Tsmt, catalyzes nucleotide exchange on EF-Tumt Cluster-8309.20306 BF_2 57.00 1.81 1607 91092780 XP_973869.1 1099 3.8e-117 PREDICTED: E3 ubiquitin-protein ligase RNF220 [Tribolium castaneum]>gi|270014897|gb|EFA11345.1| hypothetical protein TcasGA2_TC010885 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5VTB9 443 1.8e-42 E3 ubiquitin-protein ligase RNF220 OS=Homo sapiens GN=RNF220 PE=1 SV=1 PF13897//PF13639//PF15750//PF12861//PF14634//PF00097//PF15926 Golgi-dynamics membrane-trafficking//Ring finger domain//Ubiquitin-binding zinc-finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//E3 ubiquitin-protein ligase RNF220 GO:0090263//GO:0016567//GO:0006810 positive regulation of canonical Wnt signaling pathway//protein ubiquitination//transport GO:0008270//GO:0043169//GO:0046872//GO:0043130//GO:0004842//GO:0005515 zinc ion binding//cation binding//metal ion binding//ubiquitin binding//ubiquitin-protein transferase activity//protein binding GO:0016021//GO:0005680 integral component of membrane//anaphase-promoting complex -- -- Cluster-8309.20307 BF_2 58.00 3.65 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20309 BF_2 205.00 7.18 1482 546677174 ERL88064.1 1344 1.4e-145 hypothetical protein D910_05453 [Dendroctonus ponderosae] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q88168 534 4.7e-53 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.20310 BF_2 53.64 0.67 3640 478250371 ENN70866.1 967 1.8e-101 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672861|gb|ERL84584.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 B4F753 618 2.1e-62 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF02230//PF07859//PF00326//PF01764//PF00975 Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family//Lipase (class 3)//Thioesterase domain GO:0006629//GO:0009058//GO:0006508//GO:0008152 lipid metabolic process//biosynthetic process//proteolysis//metabolic process GO:0008236//GO:0016787//GO:0016788 serine-type peptidase activity//hydrolase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.20314 BF_2 817.49 10.57 3522 332373100 AEE61691.1 1682 2.1e-184 unknown [Dendroctonus ponderosae] 642911564 XM_008201254.1 402 0 PREDICTED: Tribolium castaneum casein kinase II subunit alpha-like (LOC660746), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 3.2e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.2032 BF_2 4.00 0.43 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04159 NB glycoprotein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20320 BF_2 16.00 1.42 760 803013771 XP_011977739.1 794 4.2e-82 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X1, partial [Ovis aries] 312222755 NG_000862.5 680 0 Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide pseudogene 1 (GNAQP1) on chromosome 2 K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 Q28294 794 1.7e-83 Guanine nucleotide-binding protein G(q) subunit alpha OS=Canis familiaris GN=GNAQ PE=2 SV=2 PF00503//PF00025//PF00201 G-protein alpha subunit//ADP-ribosylation factor family//UDP-glucoronosyl and UDP-glucosyl transferase GO:0007165//GO:0008152//GO:0007186 signal transduction//metabolic process//G-protein coupled receptor signaling pathway GO:0016758//GO:0031683//GO:0003924//GO:0005525//GO:0004871//GO:0019001 transferase activity, transferring hexosyl groups//G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.20321 BF_2 123.41 2.68 2211 91092532 XP_967540.1 1599 5.5e-175 PREDICTED: ankyrin-1 [Tribolium castaneum]>gi|270006612|gb|EFA03060.1| hypothetical protein TcasGA2_TC010916 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 306 1.9e-26 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF07525//PF00023//PF13606 SOCS box//Ankyrin repeat//Ankyrin repeat GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.20323 BF_2 122.60 0.89 6042 332372780 AEE61532.1 1204 9.6e-129 unknown [Dendroctonus ponderosae] 564241437 XM_006277474.1 68 4.35179e-24 PREDICTED: Alligator mississippiensis sideroflexin-1-like (LOC102569899), mRNA -- -- -- -- Q5E9M8 908 8.3e-96 Sideroflexin-1 OS=Bos taurus GN=SFXN1 PE=2 SV=3 PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.20324 BF_2 51.90 0.39 5794 270003642 EFA00090.1 2560 5.3e-286 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.4484e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 8.3e-77 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF07647//PF08040//PF00536//PF02198//PF13180//PF00595 SAM domain (Sterile alpha motif)//MNLL subunit//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006118 obsolete electron transport GO:0003954//GO:0005515//GO:0043565 NADH dehydrogenase activity//protein binding//sequence-specific DNA binding GO:0005739//GO:0005634 mitochondrion//nucleus KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.20325 BF_2 249.38 16.00 939 642924825 XP_967668.2 712 1.7e-72 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q03336 293 2.7e-25 Regucalcin OS=Rattus norvegicus GN=Rgn PE=1 SV=3 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20326 BF_2 89.97 11.27 621 60300016 AAX18656.1 317 7.0e-27 cysteine-rich protein [Apriona germari] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.20327 BF_2 21.19 0.34 2877 642916212 XP_008190932.1 3596 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- K14310 NUP205, NUP192 nuclear pore complex protein Nup205 http://www.genome.jp/dbget-bin/www_bget?ko:K14310 Q92621 1639 6.8e-181 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore KOG1835 Uncharacterized conserved protein Cluster-8309.20328 BF_2 356.81 5.30 3106 642916212 XP_008190932.1 3597 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- K14310 NUP205, NUP192 nuclear pore complex protein Nup205 http://www.genome.jp/dbget-bin/www_bget?ko:K14310 Q92621 1639 7.3e-181 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore KOG1835 Uncharacterized conserved protein Cluster-8309.20329 BF_2 498.91 7.43 3097 642916212 XP_008190932.1 2924 0.0e+00 PREDICTED: nuclear pore complex protein Nup205 [Tribolium castaneum]>gi|270004157|gb|EFA00605.1| hypothetical protein TcasGA2_TC003479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92621 823 3.1e-86 Nuclear pore complex protein Nup205 OS=Homo sapiens GN=NUP205 PE=1 SV=3 PF11894 Nuclear pore complex scaffold, nucleoporins 186/192/205 -- -- -- -- GO:0005643 nuclear pore -- -- Cluster-8309.20341 BF_2 18.46 0.97 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0016567//GO:0072519 protein ubiquitination//parasitism GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.20344 BF_2 157.22 5.04 1593 642936522 XP_008198471.1 794 8.8e-82 PREDICTED: BRCA1-A complex subunit BRE-like [Tribolium castaneum]>gi|270014127|gb|EFA10575.1| hypothetical protein TcasGA2_TC012831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SP92 377 8.2e-35 BRCA1-A complex subunit BRE OS=Mesocricetus auratus GN=Bre PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20347 BF_2 42.74 4.97 647 270011377 EFA07825.1 445 1.1e-41 hypothetical protein TcasGA2_TC005394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KM2 237 5.7e-19 Protein C10 OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20348 BF_2 21.02 0.88 1290 270011377 EFA07825.1 445 2.1e-41 hypothetical protein TcasGA2_TC005394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KM2 237 1.1e-18 Protein C10 OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20349 BF_2 750.00 23.99 1595 91086371 XP_974632.1 470 3.3e-44 PREDICTED: cytochrome b561 domain-containing protein 1 [Tribolium castaneum]>gi|270010287|gb|EFA06735.1| hypothetical protein TcasGA2_TC009666 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WUE3 141 1.9e-07 Cytochrome b561 domain-containing protein 2 OS=Mus musculus GN=Cyb561d2 PE=2 SV=1 PF03188 Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20350 BF_2 17.00 1.13 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20351 BF_2 140.00 11.79 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20353 BF_2 192.85 2.08 4159 642935912 XP_008198226.1 1993 2.1e-220 PREDICTED: BMP-binding endothelial regulator protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 947 1.7e-100 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF01479//PF00093 S4 domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.20355 BF_2 23.98 6.26 447 805809013 XP_012146731.1 162 4.7e-09 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X3 [Megachile rotundata] -- -- -- -- -- -- -- -- -- P91660 129 1.3e-06 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.20356 BF_2 17.17 1.02 993 478261429 ENN80805.1 567 1.2e-55 hypothetical protein YQE_02776, partial [Dendroctonus ponderosae]>gi|546676512|gb|ERL87506.1| hypothetical protein D910_04898 [Dendroctonus ponderosae] -- -- -- -- -- K04513 RHOA Ras homolog gene family, member A http://www.genome.jp/dbget-bin/www_bget?ko:K04513 Q24192 392 9.3e-37 Ras-like GTP-binding protein RhoL OS=Drosophila melanogaster GN=RhoL PE=2 SV=1 PF00071//PF00025//PF08477 Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.20358 BF_2 508.30 18.65 1427 91083111 XP_970182.1 1198 1.1e-128 PREDICTED: L-galactose dehydrogenase [Tribolium castaneum]>gi|270007677|gb|EFA04125.1| hypothetical protein TcasGA2_TC014368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O81884 513 1.2e-50 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1576 Predicted oxidoreductase Cluster-8309.2036 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20361 BF_2 23.02 1.01 1244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20362 BF_2 1.00 2.96 270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20363 BF_2 39.00 5.26 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02970//PF05818//PF07851//PF04111//PF05279 Tubulin binding cofactor A//Enterobacterial TraT complement resistance protein//TMPIT-like protein//Autophagy protein Apg6//Aspartyl beta-hydroxylase N-terminal region GO:0007021//GO:0046999//GO:0006914 tubulin complex assembly//regulation of conjugation//autophagy GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0016020//GO:0016021//GO:0019867//GO:0045298 membrane//integral component of membrane//outer membrane//tubulin complex -- -- Cluster-8309.20364 BF_2 20.58 0.36 2691 189236049 XP_001809395.1 503 8.2e-48 PREDICTED: tudor domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- K18404 TDRD3 tudor domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18404 Q5ZMS6 336 7.9e-30 Tudor domain-containing protein 3 OS=Gallus gallus GN=TDRD3 PE=2 SV=1 PF09103//PF06003 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1//Survival motor neuron protein (SMN) GO:0006397//GO:0000724 mRNA processing//double-strand break repair via homologous recombination GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG3683 Uncharacterized conserved protein Cluster-8309.20366 BF_2 48.72 0.81 2808 642916487 XP_008191063.1 729 5.4e-74 PREDICTED: glutathione S-transferase-like [Tribolium castaneum]>gi|642916489|ref|XP_008191064.1| PREDICTED: glutathione S-transferase-like [Tribolium castaneum]>gi|270003617|gb|EFA00065.1| hypothetical protein TcasGA2_TC002878 [Tribolium castaneum] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 P46428 354 6.7e-32 Glutathione S-transferase OS=Anopheles gambiae GN=GstS1 PE=2 SV=4 PF13409//PF02798//PF13417//PF05529 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//B-cell receptor-associated protein 31-like GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG1695 Glutathione S-transferase Cluster-8309.20368 BF_2 70.10 0.90 3551 642922747 XP_008193307.1 1618 5.6e-177 PREDICTED: MAGUK p55 subfamily member 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14168 779 4.4e-81 MAGUK p55 subfamily member 2 OS=Homo sapiens GN=MPP2 PE=1 SV=3 PF13180//PF00595//PF14604//PF00018//PF03193 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Variant SH3 domain//SH3 domain//Protein of unknown function, DUF258 -- -- GO:0005515//GO:0003924//GO:0005525 protein binding//GTPase activity//GTP binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.20370 BF_2 43.64 0.55 3603 642923250 XP_008193676.1 2810 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 95 2.53028e-39 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 1531 2.8e-168 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF00023//PF00097//PF13606//PF07649//PF06701//PF00569 Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//C1-like domain//Mib_herc2//Zinc finger, ZZ type GO:0055114//GO:0016567 oxidation-reduction process//protein ubiquitination GO:0004842//GO:0047134//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//protein-disulfide reductase activity//metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.20371 BF_2 592.00 5.50 4790 91080987 XP_974999.1 2988 0.0e+00 PREDICTED: WD repeat-containing protein 48 homolog [Tribolium castaneum] -- -- -- -- -- K15361 WDR48, UAF1 WD repeat-containing protein 48 http://www.genome.jp/dbget-bin/www_bget?ko:K15361 Q16MY0 1948 1.7e-216 WD repeat-containing protein 48 homolog OS=Aedes aegypti GN=AAEL012158 PE=3 SV=1 PF03079//PF02311//PF00400 ARD/ARD' family//AraC-like ligand binding domain//WD domain, G-beta repeat GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0010309//GO:0005515 acireductone dioxygenase [iron(II)-requiring] activity//protein binding -- -- KOG0308 Conserved WD40 repeat-containing protein Cluster-8309.20372 BF_2 54.00 6.11 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20373 BF_2 248.89 4.33 2694 91081805 XP_974174.1 1438 3.1e-156 PREDICTED: equilibrative nucleoside transporter 3 [Tribolium castaneum]>gi|270006294|gb|EFA02742.1| hypothetical protein TcasGA2_TC008473 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 553 5.4e-55 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733//PF07247 Nucleoside transporter//Alcohol acetyltransferase GO:0042967//GO:0006810//GO:0006066//GO:0015858 acyl-carrier-protein biosynthetic process//transport//alcohol metabolic process//nucleoside transport GO:0004026//GO:0005337 alcohol O-acetyltransferase activity//nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.20375 BF_2 143.88 2.34 2857 795013623 XP_011883597.1 900 8.1e-94 PREDICTED: uncharacterized protein LOC105570767 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 178 1.7e-11 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.20379 BF_2 547.20 10.12 2550 91083363 XP_975142.1 1914 1.9e-211 PREDICTED: diacylglycerol O-acyltransferase 1 [Tribolium castaneum]>gi|270007773|gb|EFA04221.1| hypothetical protein TcasGA2_TC014471 [Tribolium castaneum] -- -- -- -- -- K11155 DGAT1 diacylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11155 Q9Z2A7 996 2.2e-106 Diacylglycerol O-acyltransferase 1 OS=Mus musculus GN=Dgat1 PE=1 SV=1 -- -- GO:0042967 acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase Cluster-8309.20381 BF_2 7.00 37.09 251 123389586 XP_001299746.1 203 4.7e-14 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121880660|gb|EAX86816.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q4UMH6 171 9.9e-12 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20388 BF_2 141.93 3.06 2228 546683467 ERL93273.1 1208 1.2e-129 hypothetical protein D910_10569, partial [Dendroctonus ponderosae] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 2.7e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF04277//PF07525 Oxaloacetate decarboxylase, gamma chain//SOCS box GO:0006525//GO:0006560//GO:0071436//GO:0006090//GO:0006814//GO:0035556 arginine metabolic process//proline metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport//intracellular signal transduction GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.20389 BF_2 235.86 3.54 3077 478255137 ENN75367.1 1626 5.7e-178 hypothetical protein YQE_08142, partial [Dendroctonus ponderosae] 642914874 XM_965920.3 58 7.98121e-19 PREDICTED: Tribolium castaneum protein inscuteable homolog (LOC659633), mRNA -- -- -- -- Q3HNM7 345 8.1e-31 Protein inscuteable homolog OS=Mus musculus GN=Insc PE=1 SV=2 PF00514//PF01066 Armadillo/beta-catenin-like repeat//CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0005515//GO:0016780 protein binding//phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane -- -- Cluster-8309.20390 BF_2 22.07 0.43 2410 91089063 XP_970679.1 2031 4.9e-225 PREDICTED: N-sulphoglucosamine sulphohydrolase isoform X1 [Tribolium castaneum]>gi|270012406|gb|EFA08854.1| hypothetical protein TcasGA2_TC006555 [Tribolium castaneum] 584037463 XM_006753050.1 45 1.05078e-11 PREDICTED: Myotis davidii N-sulfoglucosamine sulfohydrolase (SGSH), partial mRNA K01565 SGSH N-sulfoglucosamine sulfohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01565 P51688 1498 1.3e-164 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens GN=SGSH PE=1 SV=1 PF00010//PF02076//PF07931//PF00884//PF01663//PF09004 Helix-loop-helix DNA-binding domain//Pheromone A receptor//Chloramphenicol phosphotransferase-like protein//Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Domain of unknown function (DUF1891) GO:0007186//GO:0055114//GO:0019236//GO:0007606//GO:0008152 G-protein coupled receptor signaling pathway//oxidation-reduction process//response to pheromone//sensory perception of chemical stimulus//metabolic process GO:0016706//GO:0008484//GO:0008168//GO:0004932//GO:0003824//GO:0005524//GO:0016740//GO:0046983 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//sulfuric ester hydrolase activity//methyltransferase activity//mating-type factor pheromone receptor activity//catalytic activity//ATP binding//transferase activity//protein dimerization activity GO:0016021 integral component of membrane KOG3867 Sulfatase Cluster-8309.20391 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02962 5-carboxymethyl-2-hydroxymuconate isomerase GO:0006570//GO:0018874//GO:0019439 tyrosine metabolic process//benzoate metabolic process//aromatic compound catabolic process GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity -- -- -- -- Cluster-8309.20394 BF_2 723.51 9.00 3650 642934335 XP_969733.2 2984 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 1.19274e-37 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF09815//PF05524//PF01436//PF14634//PF00643//PF05929//PF00097//PF02601//PF01580//PF13639//PF05149//PF01637 XK-related protein//PEP-utilising enzyme, N-terminal//NHL repeat//zinc-RING finger domain//B-box zinc finger//Phage capsid scaffolding protein (GPO) serine peptidase//Zinc finger, C3HC4 type (RING finger)//Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain//Paraflagellar rod protein//Archaeal ATPase GO:0006308//GO:0019069//GO:0009401 DNA catabolic process//viral capsid assembly//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0046872//GO:0008270//GO:0000166//GO:0008855//GO:0005515//GO:0005524//GO:0005516//GO:0003677 metal ion binding//zinc ion binding//nucleotide binding//exodeoxyribonuclease VII activity//protein binding//ATP binding//calmodulin binding//DNA binding GO:0009318//GO:0005622//GO:0016021//GO:0031514 exodeoxyribonuclease VII complex//intracellular//integral component of membrane//motile cilium -- -- Cluster-8309.20396 BF_2 24.02 0.38 2954 91085723 XP_973304.1 152 4.5e-07 PREDICTED: [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Tribolium castaneum]>gi|270010109|gb|EFA06557.1| hypothetical protein TcasGA2_TC009468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.20397 BF_2 19.25 0.35 2608 91083569 XP_967824.1 831 7.4e-86 PREDICTED: transport and Golgi organization protein 11 [Tribolium castaneum]>gi|270007821|gb|EFA04269.1| hypothetical protein TcasGA2_TC014559 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q961C9 347 4.0e-31 Transport and Golgi organization protein 11 OS=Drosophila melanogaster GN=Tango11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20401 BF_2 753.00 61.42 800 478260242 ENN80002.1 162 8.5e-09 hypothetical protein YQE_03563, partial [Dendroctonus ponderosae]>gi|546684043|gb|ERL93766.1| hypothetical protein D910_11052 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20403 BF_2 5.00 0.43 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20404 BF_2 186.37 2.29 3696 189235566 XP_970111.2 1374 1.1e-148 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q86KF9 297 3.6e-25 Sphingosine kinase A OS=Dictyostelium discoideum GN=sgkA PE=2 SV=2 PF03838 Recombination protein U GO:0007205//GO:0009395//GO:0006310//GO:0006281//GO:0046486 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//DNA recombination//DNA repair//glycerolipid metabolic process GO:0004143 diacylglycerol kinase activity GO:0005737 cytoplasm KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.20405 BF_2 50.63 0.61 3769 189235566 XP_970111.2 1374 1.2e-148 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q86KF9 297 3.7e-25 Sphingosine kinase A OS=Dictyostelium discoideum GN=sgkA PE=2 SV=2 PF03838 Recombination protein U GO:0006281//GO:0046486//GO:0006310//GO:0007205//GO:0009395 DNA repair//glycerolipid metabolic process//DNA recombination//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0004143 diacylglycerol kinase activity GO:0005737 cytoplasm KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.20406 BF_2 39.34 1.82 1192 189235566 XP_970111.2 1019 5.3e-108 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q9JIA7 216 2.9e-16 Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain GO:0009395//GO:0007205//GO:0046486 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//glycerolipid metabolic process GO:0004143//GO:0016301 diacylglycerol kinase activity//kinase activity -- -- KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.20408 BF_2 7.00 1.54 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20409 BF_2 58.79 1.48 1944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20417 BF_2 36.37 0.46 3608 642923250 XP_008193676.1 4520 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 237 2.92693e-118 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 2033 1.8e-226 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF13639//PF06701//PF00569//PF00023//PF00097//PF13606//PF07649 Ring finger domain//Mib_herc2//Zinc finger, ZZ type//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//C1-like domain GO:0055114//GO:0016567 oxidation-reduction process//protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0047134//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//protein-disulfide reductase activity//metal ion binding -- -- -- -- Cluster-8309.2042 BF_2 12.00 0.81 904 550540770 G9JJU2.1 630 5.2e-63 RecName: Full=Glutathione peroxidase; Short=PcGPx; Short=Se-PcGPx [Procambarus clarkii]>gi|358357317|gb|AEU08498.1| selenium-dependent glutathione peroxidase [Procambarus clarkii] -- -- -- -- -- K00432 E1.11.1.9 glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00432 G9JJU2 630 2.1e-64 Glutathione peroxidase OS=Procambarus clarkii GN=GPx PE=2 SV=1 PF00255 Glutathione peroxidase GO:0006749//GO:0055114//GO:0006804//GO:0006979 glutathione metabolic process//oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress GO:0004602 glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-8309.20420 BF_2 97.52 0.51 8288 189234173 XP_968418.2 1427 1.8e-154 PREDICTED: RNA-binding protein Musashi homolog 2 isoform X2 [Tribolium castaneum] 642912293 XM_963325.3 503 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog 2 (LOC656824), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q96DH6 622 1.7e-62 RNA-binding protein Musashi homolog 2 OS=Homo sapiens GN=MSI2 PE=1 SV=1 PF08777//PF05014//PF03852//PF16367//PF01692//PF00076//PF01371//PF01213 RNA binding motif//Nucleoside 2-deoxyribosyltransferase//DNA mismatch endonuclease Vsr//RNA recognition motif//Paramyxovirus non-structural protein C//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Trp repressor protein//Adenylate cyclase associated (CAP) N terminal GO:0009159//GO:0007010//GO:0006298//GO:0030683//GO:0006206//GO:0006355 deoxyribonucleoside monophosphate catabolic process//cytoskeleton organization//mismatch repair//evasion or tolerance by virus of host immune response//pyrimidine nucleobase metabolic process//regulation of transcription, DNA-templated GO:0050144//GO:0003779//GO:0070694//GO:0004519//GO:0003723//GO:0003700//GO:0003676 nucleoside deoxyribosyltransferase activity//actin binding//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//endonuclease activity//RNA binding//transcription factor activity, sequence-specific DNA binding//nucleic acid binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.20425 BF_2 33.04 1.67 1115 501296187 BAN20955.1 397 6.7e-36 conserved hypothetical protein [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q9VBV3 253 1.4e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20428 BF_2 3.00 3.32 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20429 BF_2 24.06 1.75 862 270006684 EFA03132.1 743 3.9e-76 hypothetical protein TcasGA2_TC013044 [Tribolium castaneum] 642924851 XM_008195844.1 184 1.96943e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 547 8.6e-55 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.20430 BF_2 2.00 0.35 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20432 BF_2 50.58 1.54 1660 728418014 AIY68354.1 1391 5.5e-151 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 599 1.5e-60 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.20434 BF_2 12.79 0.32 1943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20435 BF_2 57.31 1.02 2647 642920871 XP_008192594.1 1610 3.5e-176 PREDICTED: protein turtle isoform X9 [Tribolium castaneum]>gi|270006125|gb|EFA02573.1| hypothetical protein TcasGA2_TC008291 [Tribolium castaneum] 645007404 XM_008218033.1 69 5.26375e-25 PREDICTED: Nasonia vitripennis protein turtle (LOC100119623), mRNA -- -- -- -- Q967D7 503 3.3e-49 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20439 BF_2 12.36 0.78 947 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03335 Phage tail fibre repeat -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.20441 BF_2 6.00 0.36 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20442 BF_2 513.87 4.11 5515 156123605 ABU50692.1 2672 5.2e-299 cadherin-like protein [Diabrotica virgifera virgifera]>gi|157384055|gb|AAV88529.2| cadherin-like protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- Q9VW71 270 7.2e-22 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF06363//PF00028 Picornaviridae P3A protein//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0019012//GO:0016020 virion//membrane -- -- Cluster-8309.20443 BF_2 2749.64 22.67 5360 156123605 ABU50692.1 2882 0.0e+00 cadherin-like protein [Diabrotica virgifera virgifera]>gi|157384055|gb|AAV88529.2| cadherin-like protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- Q9VW71 270 7.0e-22 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF06363//PF00028 Picornaviridae P3A protein//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0019012//GO:0016020 virion//membrane -- -- Cluster-8309.20444 BF_2 21.00 1.10 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20445 BF_2 7.00 0.89 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20453 BF_2 27.00 1.03 1383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20454 BF_2 57.00 1.83 1589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20457 BF_2 16.98 4.13 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20459 BF_2 1428.96 29.05 2345 546682401 ERL92343.1 1201 8.3e-129 hypothetical protein D910_09660 [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 735 3.7e-76 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.20462 BF_2 661.00 7.66 3895 646716227 KDR19556.1 2498 5.5e-279 Protein ariadne-1 [Zootermopsis nevadensis] 642911729 XM_008202494.1 547 0 PREDICTED: Tribolium castaneum protein ariadne-1 (LOC660216), mRNA K11968 ARIH1 ariadne-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11968 Q94981 2084 2.3e-232 Protein ariadne-1 OS=Drosophila melanogaster GN=ari-1 PE=1 SV=2 PF13639//PF00097 Ring finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.20467 BF_2 4094.00 188.86 1194 91092316 XP_970010.1 1360 1.5e-147 PREDICTED: beta-1,3-glucan-binding protein [Tribolium castaneum]>gi|270015726|gb|EFA12174.1| Gram-negative bacteria binding protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N0N3 915 2.5e-97 Beta-1,3-glucan-binding protein OS=Penaeus monodon PE=2 SV=1 PF00722 Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.20469 BF_2 77.03 1.34 2698 766933019 XP_011498756.1 677 5.5e-68 PREDICTED: zinc finger protein 836-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- A2CE44 508 9.0e-50 Zinc finger X-linked protein ZXDB OS=Mus musculus GN=Zxdb PE=2 SV=1 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.20473 BF_2 286.00 11.08 1367 478255717 ENN75926.1 208 6.7e-14 hypothetical protein YQE_07463, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15048//PF03606//PF15096//PF06682//PF04277 Organic solute transporter subunit beta protein//C4-dicarboxylate anaerobic carrier//G6B family//SOCE-associated regulatory factor of calcium homoeostasis//Oxaloacetate decarboxylase, gamma chain GO:0006810//GO:0015721//GO:0006525//GO:2001256//GO:0006814//GO:0006090//GO:0071436//GO:0006560 transport//bile acid and bile salt transport//arginine metabolic process//regulation of store-operated calcium entry//sodium ion transport//pyruvate metabolic process//sodium ion export//proline metabolic process GO:0008948//GO:0005215//GO:0046982//GO:0015081 oxaloacetate decarboxylase activity//transporter activity//protein heterodimerization activity//sodium ion transmembrane transporter activity GO:0016021//GO:0030176//GO:0005886//GO:0016020 integral component of membrane//integral component of endoplasmic reticulum membrane//plasma membrane//membrane -- -- Cluster-8309.20475 BF_2 900.00 35.09 1360 807034166 XP_012159090.1 151 2.7e-07 PREDICTED: ovomucoid-like [Ceratitis capitata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20477 BF_2 17.00 0.55 1580 91079869 XP_967328.1 1728 4.3e-190 PREDICTED: JNK-interacting protein 1 [Tribolium castaneum]>gi|270003280|gb|EEZ99727.1| hypothetical protein TcasGA2_TC002493 [Tribolium castaneum] 642918276 XM_962235.3 413 0 PREDICTED: Tribolium castaneum JNK-interacting protein 1 (LOC655673), mRNA K04434 MAPK8IP1, JIP1 mitogen-activated protein kinase 8 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04434 Q9W0K0 1113 3.7e-120 JNK-interacting protein 1 OS=Drosophila melanogaster GN=Aplip1 PE=1 SV=2 PF00640//PF08416//PF14604//PF00018//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Variant SH3 domain//SH3 domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG3775 Mitogen-activated protein kinase scaffold protein JIP Cluster-8309.20478 BF_2 420.18 4.15 4520 91082383 XP_968748.1 3906 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2657 9.7e-299 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF00910//PF03193//PF03266//PF00005//PF01637//PF01695//PF13304//PF01372//PF01926//PF00664//PF00931//PF01580//PF02367//PF06414//PF03205 Type II/IV secretion system protein//RNA helicase//Protein of unknown function, DUF258//NTPase//ABC transporter//Archaeal ATPase//IstB-like ATP binding protein//AAA domain, putative AbiEii toxin, Type IV TA system//Melittin//50S ribosome-binding GTPase//ABC transporter transmembrane region//NB-ARC domain//FtsK/SpoIIIE family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Molybdopterin guanine dinucleotide synthesis protein B GO:0055085//GO:0006810//GO:0006777//GO:0009987//GO:0045859//GO:0002949 transmembrane transport//transport//Mo-molybdopterin cofactor biosynthetic process//cellular process//regulation of protein kinase activity//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0003924//GO:0000166//GO:0016301//GO:0016887//GO:0042626//GO:0003723//GO:0004860//GO:0003677//GO:0043531//GO:0005525//GO:0003724 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//nucleotide binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//RNA binding//protein kinase inhibitor activity//DNA binding//ADP binding//GTP binding//RNA helicase activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.20479 BF_2 166.48 4.56 1816 91076740 XP_973178.1 1038 5.1e-110 PREDICTED: tetraspanin-11 [Tribolium castaneum]>gi|270001854|gb|EEZ98301.1| hypothetical protein TcasGA2_TC000754 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF00335 Oxaloacetate decarboxylase, gamma chain//Tetraspanin family GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0006090 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.20483 BF_2 115.00 2.67 2087 270013287 EFA09735.1 263 4.3e-20 hypothetical protein TcasGA2_TC011868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01857 Retinoblastoma-associated protein B domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.20484 BF_2 10.19 0.52 1107 607356865 EZA51356.1 862 8.0e-90 hypothetical protein X777_10005, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0008408//GO:0003677//GO:0000166//GO:0003887 3'-5' exonuclease activity//DNA binding//nucleotide binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.20485 BF_2 3.46 0.52 564 759051754 XP_011335000.1 460 1.7e-43 PREDICTED: uncharacterized protein LOC105277946 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20486 BF_2 24.00 2.22 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20488 BF_2 11.16 0.45 1331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20492 BF_2 75.31 7.13 729 73921480 AAZ94270.1 468 2.5e-44 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 309 2.9e-27 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00336//PF15681//PF00067 DNA polymerase (viral) C-terminal domain//Lymphocyte activation family X//Cytochrome P450 GO:0051252//GO:0055114//GO:0006955//GO:0051249 regulation of RNA metabolic process//oxidation-reduction process//immune response//regulation of lymphocyte activation GO:0005506//GO:0004523//GO:0020037//GO:0016705 iron ion binding//RNA-DNA hybrid ribonuclease activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.20493 BF_2 2.00 0.64 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20495 BF_2 99.38 2.16 2208 642938537 XP_008199832.1 1069 1.6e-113 PREDICTED: UDP-xylose and UDP-N-acetylglucosamine transporter [Tribolium castaneum]>gi|270015580|gb|EFA12028.1| hypothetical protein TcasGA2_TC001443 [Tribolium castaneum] -- -- -- -- -- K15278 SLC35B4, YEA4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 http://www.genome.jp/dbget-bin/www_bget?ko:K15278 Q9W429 876 1.6e-92 UDP-xylose and UDP-N-acetylglucosamine transporter OS=Drosophila melanogaster GN=Efr PE=2 SV=1 PF08449//PF03165//PF00892 UAA transporter family//MH1 domain//EamA-like transporter family GO:0055085//GO:0008643//GO:0015780//GO:0006355 transmembrane transport//carbohydrate transport//nucleotide-sugar transport//regulation of transcription, DNA-templated GO:0005338 nucleotide-sugar transmembrane transporter activity GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG1583 UDP-N-acetylglucosamine transporter Cluster-8309.20496 BF_2 768.74 17.18 2159 642938537 XP_008199832.1 1174 1.0e-125 PREDICTED: UDP-xylose and UDP-N-acetylglucosamine transporter [Tribolium castaneum]>gi|270015580|gb|EFA12028.1| hypothetical protein TcasGA2_TC001443 [Tribolium castaneum] -- -- -- -- -- K15278 SLC35B4, YEA4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 http://www.genome.jp/dbget-bin/www_bget?ko:K15278 Q9W429 939 7.5e-100 UDP-xylose and UDP-N-acetylglucosamine transporter OS=Drosophila melanogaster GN=Efr PE=2 SV=1 PF03165//PF08449//PF00892 MH1 domain//UAA transporter family//EamA-like transporter family GO:0008643//GO:0015780//GO:0006355//GO:0055085 carbohydrate transport//nucleotide-sugar transport//regulation of transcription, DNA-templated//transmembrane transport GO:0005338 nucleotide-sugar transmembrane transporter activity GO:0016020//GO:0005622//GO:0016021 membrane//intracellular//integral component of membrane KOG1583 UDP-N-acetylglucosamine transporter Cluster-8309.20497 BF_2 111.88 2.38 2252 642938537 XP_008199832.1 1132 8.0e-121 PREDICTED: UDP-xylose and UDP-N-acetylglucosamine transporter [Tribolium castaneum]>gi|270015580|gb|EFA12028.1| hypothetical protein TcasGA2_TC001443 [Tribolium castaneum] -- -- -- -- -- K15278 SLC35B4, YEA4 solute carrier family 35 (UDP-xylose/UDP-N-acetylglucosamine transporter), member B4 http://www.genome.jp/dbget-bin/www_bget?ko:K15278 Q9W429 890 3.8e-94 UDP-xylose and UDP-N-acetylglucosamine transporter OS=Drosophila melanogaster GN=Efr PE=2 SV=1 PF00892//PF08449//PF03165 EamA-like transporter family//UAA transporter family//MH1 domain GO:0071702//GO:0006355//GO:0044765//GO:0055085 organic substance transport//regulation of transcription, DNA-templated//single-organism transport//transmembrane transport -- -- GO:0016021//GO:0005622//GO:0016020 integral component of membrane//intracellular//membrane KOG1583 UDP-N-acetylglucosamine transporter Cluster-8309.20499 BF_2 168.93 4.68 1797 642921155 XP_975421.2 1483 1.3e-161 PREDICTED: nitrilase and fragile histidine triad fusion protein NitFhit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76464 1092 1.1e-117 Nitrilase and fragile histidine triad fusion protein NitFhit OS=Drosophila melanogaster GN=NitFhit PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0807 Carbon-nitrogen hydrolase Cluster-8309.205 BF_2 3.00 0.81 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2050 BF_2 29.00 0.38 3449 642911161 XP_008200606.1 3881 0.0e+00 PREDICTED: metabotropic glutamate receptor [Tribolium castaneum] 642911160 XM_008202384.1 684 0 PREDICTED: Tribolium castaneum metabotropic glutamate receptor (LOC661133), mRNA K04605 GRM2_3 metabotropic glutamate receptor 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K04605 P91685 3059 0.0e+00 Metabotropic glutamate receptor OS=Drosophila melanogaster GN=mGluR PE=1 SV=2 PF00003//PF02649//PF07562 7 transmembrane sweet-taste receptor of 3 GCPR//Type I GTP cyclohydrolase folE2//Nine Cysteines Domain of family 3 GPCR GO:0007186//GO:0006807 G-protein coupled receptor signaling pathway//nitrogen compound metabolic process GO:0004930//GO:0003933 G-protein coupled receptor activity//GTP cyclohydrolase activity GO:0016021 integral component of membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.20509 BF_2 89.00 8.66 717 642922973 XP_008200475.1 212 1.2e-14 PREDICTED: RNMT-activating mini protein-like [Tribolium castaneum]>gi|270006584|gb|EFA03032.1| hypothetical protein TcasGA2_TC010457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05656//PF15320 Protein of unknown function (DUF805)//mRNA cap methylation, RNMT-activating mini protein GO:0032259 methylation GO:0003723 RNA binding GO:0005845//GO:0016021 mRNA cap binding complex//integral component of membrane -- -- Cluster-8309.20513 BF_2 279.00 521.12 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20515 BF_2 20.00 0.70 1486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20517 BF_2 235.72 14.03 990 91091696 XP_972659.1 620 8.2e-62 PREDICTED: nogo-B receptor [Tribolium castaneum]>gi|270001062|gb|EEZ97509.1| hypothetical protein TcasGA2_TC011353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99LJ8 268 2.2e-22 Dehydrodolichyl diphosphate syntase complex subunit Nus1 OS=Mus musculus GN=Nus1 PE=2 SV=1 PF01255 Putative undecaprenyl diphosphate synthase -- -- GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups -- -- KOG2818 Predicted undecaprenyl diphosphate synthase Cluster-8309.20519 BF_2 34.56 0.60 2716 91085713 XP_972970.1 1384 5.8e-150 PREDICTED: cyclin-H [Tribolium castaneum]>gi|270010021|gb|EFA06469.1| hypothetical protein TcasGA2_TC009354 [Tribolium castaneum] -- -- -- -- -- K06634 CCNH cyclin H http://www.genome.jp/dbget-bin/www_bget?ko:K06634 P51946 581 3.1e-58 Cyclin-H OS=Homo sapiens GN=CCNH PE=1 SV=1 PF00382//PF01857//PF02984 Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Cyclin, C-terminal domain GO:0000079//GO:0006355//GO:0051726 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated//regulation of cell cycle GO:0017025//GO:0019901 TBP-class protein binding//protein kinase binding GO:0005675//GO:0005634 holo TFIIH complex//nucleus KOG2496 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit Cluster-8309.20521 BF_2 1278.23 8.41 6646 642922382 XP_008193134.1 7387 0.0e+00 PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|270007200|gb|EFA03648.1| hypothetical protein TcasGA2_TC013742 [Tribolium castaneum] 642922381 XM_008194912.1 96 1.30307e-39 PREDICTED: Tribolium castaneum myosin 7B (LOC662874), mRNA K10359 MYO7 myosin VII http://www.genome.jp/dbget-bin/www_bget?ko:K10359 Q29P71 5404 0.0e+00 Myosin-VIIa OS=Drosophila pseudoobscura pseudoobscura GN=ck PE=3 SV=1 PF00612//PF00784//PF00063 IQ calmodulin-binding motif//MyTH4 domain//Myosin head (motor domain) -- -- GO:0005515//GO:0003774//GO:0005524 protein binding//motor activity//ATP binding GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.20522 BF_2 171.63 1.05 7110 642922382 XP_008193134.1 7351 0.0e+00 PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|270007200|gb|EFA03648.1| hypothetical protein TcasGA2_TC013742 [Tribolium castaneum] 642922381 XM_008194912.1 96 1.39456e-39 PREDICTED: Tribolium castaneum myosin 7B (LOC662874), mRNA K10359 MYO7 myosin VII http://www.genome.jp/dbget-bin/www_bget?ko:K10359 Q17LW0 5371 0.0e+00 Myosin-VIIa OS=Aedes aegypti GN=ck PE=3 SV=1 PF00063//PF00612//PF00784 Myosin head (motor domain)//IQ calmodulin-binding motif//MyTH4 domain -- -- GO:0005515//GO:0003774//GO:0005524 protein binding//motor activity//ATP binding GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.20523 BF_2 146.00 4.47 1654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20524 BF_2 10.94 0.69 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20525 BF_2 80.64 1.31 2862 642921203 XP_008192760.1 1329 1.5e-143 PREDICTED: uncharacterized protein LOC103312841 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 P82798 286 5.2e-24 Transcriptional regulator ATRX (Fragment) OS=Macropus eugenii GN=ATRX PE=2 SV=1 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.20526 BF_2 10.00 2.28 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20528 BF_2 6.00 0.40 915 -- -- -- -- -- 525346494 KC793965.1 196 4.47222e-96 Scylla paramamosain clone Scpa73 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20529 BF_2 8.00 3.63 377 395731974 XP_002812204.2 241 2.8e-18 PREDICTED: ALK tyrosine kinase receptor, partial [Pongo abelii] 221554531 NG_009445.1 377 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 234 7.4e-19 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2053 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20530 BF_2 38.26 0.81 2258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20531 BF_2 2.41 0.47 499 642940435 XP_008194234.1 498 5.8e-48 PREDICTED: rho GTPase-activating protein 26, partial [Tribolium castaneum] -- -- -- -- -- K13736 ARHGAP10 Rho GTPase-activating protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13736 Q5U4T3 283 2.0e-24 Rho GTPase-activating protein 26 OS=Xenopus laevis GN=arhgap26 PE=2 SV=1 PF12361//PF00620 Duffy-antigen binding protein//RhoGAP domain GO:0007165 signal transduction -- -- GO:0016020 membrane KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.20535 BF_2 132.00 8.95 904 546675036 ERL86297.1 794 5.0e-82 hypothetical protein D910_03705 [Dendroctonus ponderosae] -- -- -- -- -- K02879 RP-L17, MRPL17, rplQ large subunit ribosomal protein L17 http://www.genome.jp/dbget-bin/www_bget?ko:K02879 Q9D8P4 301 3.0e-26 39S ribosomal protein L17, mitochondrial OS=Mus musculus GN=Mrpl17 PE=1 SV=1 PF01196 Ribosomal protein L17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3280 Mitochondrial/chloroplast ribosomal protein L17 Cluster-8309.20537 BF_2 87.61 0.58 6583 546680884 ERL91070.1 2441 3.8e-272 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q9NSI6 1506 4.1e-165 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens GN=BRWD1 PE=1 SV=4 PF06507//PF00439//PF02798//PF13417//PF10717//PF00400//PF13409 Auxin response factor//Bromodomain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Occlusion-derived virus envelope protein ODV-E18//WD domain, G-beta repeat//Glutathione S-transferase, N-terminal domain GO:0006355//GO:0009725 regulation of transcription, DNA-templated//response to hormone GO:0005515//GO:0003677 protein binding//DNA binding GO:0019031//GO:0005634 viral envelope//nucleus KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.20538 BF_2 8.00 5.16 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20539 BF_2 1525.00 42.62 1784 728418014 AIY68354.1 1560 1.5e-170 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01044 CES1 carboxylesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01044 B2D0J5 641 2.2e-65 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.20540 BF_2 15.00 0.62 1306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20541 BF_2 29.00 1.00 1501 270004929 EFA01377.1 1424 7.4e-155 hypothetical protein TcasGA2_TC030877 [Tribolium castaneum] -- -- -- -- -- K06827 CTGF connective tissue growth factor http://www.genome.jp/dbget-bin/www_bget?ko:K06827 O54775 456 5.3e-44 WNT1-inducible-signaling pathway protein 1 OS=Mus musculus GN=Wisp1 PE=2 SV=1 PF00093//PF00219 von Willebrand factor type C domain//Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520//GO:0005515 insulin-like growth factor binding//protein binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.20543 BF_2 46.11 0.45 4577 641658103 XP_008180598.1 728 1.1e-73 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 668 4.3e-68 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF07776//PF13912//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.20546 BF_2 47.70 0.38 5526 642914389 XP_008201657.1 245 1.4e-17 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 195 3.6e-13 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20547 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20548 BF_2 455.00 19.45 1266 584482884 AHJ09939.1 1495 3.6e-163 glycoside hydrolase family 28 [Apriona japonica] 584482883 KF724641.1 1083 0 Apriona japonica glycoside hydrolase family 28 (gh28-1) mRNA, complete cds -- -- -- -- Q9P4W4 695 8.7e-72 Endopolygalacturonase A OS=Aspergillus niger GN=pgaA PE=1 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005982//GO:0005985//GO:0005975 starch metabolic process//sucrose metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.20549 BF_2 131.88 2.90 2187 642933809 XP_008197363.1 1019 9.8e-108 PREDICTED: G-protein coupled receptor 143 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51810 280 2.0e-23 G-protein coupled receptor 143 OS=Homo sapiens GN=GPR143 PE=1 SV=2 PF00002//PF01534//PF02101 7 transmembrane receptor (Secretin family)//Frizzled/Smoothened family membrane region//Ocular albinism type 1 protein GO:0007186//GO:0007166 G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.20551 BF_2 1.00 1.91 287 123494860 XP_001326609.1 235 1.0e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 179 1.3e-12 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.20552 BF_2 2.00 1.71 328 123494860 XP_001326609.1 216 1.9e-15 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- P17221 156 7.1e-10 Sex-determining protein fem-1 OS=Caenorhabditis elegans GN=fem-1 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20554 BF_2 1.00 1.52 297 123494860 XP_001326609.1 230 4.1e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 P17221 165 5.8e-11 Sex-determining protein fem-1 OS=Caenorhabditis elegans GN=fem-1 PE=1 SV=1 PF00023//PF13606//PF04857 Ankyrin repeat//Ankyrin repeat//CAF1 family ribonuclease -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.20562 BF_2 13.00 0.82 948 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.20567 BF_2 795.11 45.26 1022 501296187 BAN20955.1 397 6.1e-36 conserved hypothetical protein [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q9VBV3 253 1.3e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20568 BF_2 22.63 5.98 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20569 BF_2 208.04 3.60 2702 163716724 ABY40586.1 193 7.3e-12 gustatory receptor [Tribolium castaneum]>gi|270006488|gb|EFA02936.1| gustatory receptor 103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20570 BF_2 155.25 6.82 1239 91089019 XP_968547.1 310 9.1e-26 PREDICTED: mitogen-activated protein kinase kinase kinase 7 [Tribolium castaneum]>gi|270012716|gb|EFA09164.1| TGF-beta activated kinase 1 [Tribolium castaneum] -- -- -- -- -- K04427 MAP3K7, TAK1 mitogen-activated protein kinase kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04427 P0C8E4 142 1.1e-07 Mitogen-activated protein kinase kinase kinase 7 OS=Rattus norvegicus GN=Map3k7 PE=2 SV=1 -- -- GO:0016310 phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.20573 BF_2 5.97 0.64 678 642925139 XP_001813550.2 274 7.4e-22 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF13912//PF13465//PF00096//PF15750 BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Ubiquitin-binding zinc-finger -- -- GO:0046872//GO:0043130//GO:0003677 metal ion binding//ubiquitin binding//DNA binding -- -- -- -- Cluster-8309.20574 BF_2 22.51 0.35 2970 642925139 XP_001813550.2 533 3.0e-51 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42282 287 4.2e-24 Protein tramtrack, alpha isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=3 PF00096//PF02892//PF00651 Zinc finger, C2H2 type//BED zinc finger//BTB/POZ domain -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.2058 BF_2 43.00 0.64 3102 642934903 XP_008197856.1 2510 1.8e-280 PREDICTED: WD repeat and HMG-box DNA-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K11274 WDHD1, CTF4 chromosome transmission fidelity protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11274 O75717 1036 6.1e-111 WD repeat and HMG-box DNA-binding protein 1 OS=Homo sapiens GN=WDHD1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1274 WD40 repeat protein Cluster-8309.20582 BF_2 10.51 0.41 1371 642913197 XP_008201432.1 479 2.5e-45 PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913199|ref|XP_008201433.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913201|ref|XP_008201434.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 281 9.5e-24 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.20584 BF_2 105.79 2.71 1921 270009743 EFA06191.1 1602 2.2e-175 hypothetical protein TcasGA2_TC009040 [Tribolium castaneum] 805761554 XM_012298644.1 131 1.30093e-59 PREDICTED: Megachile rotundata CCA tRNA nucleotidyltransferase 1, mitochondrial (LOC100882545), transcript variant X2, mRNA K00974 cca tRNA nucleotidyltransferase (CCA-adding enzyme) http://www.genome.jp/dbget-bin/www_bget?ko:K00974 Q96Q11 1074 1.5e-115 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=TRNT1 PE=1 SV=2 PF01743 Poly A polymerase head domain GO:0006396 RNA processing GO:0003723//GO:0016779 RNA binding//nucleotidyltransferase activity -- -- KOG2159 tRNA nucleotidyltransferase/poly(A) polymerase Cluster-8309.20588 BF_2 182.05 0.98 8086 642930915 XP_008196139.1 1612 6.3e-176 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 4.6e-49 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.20589 BF_2 18.94 0.49 1915 270011411 EFA07859.1 531 3.3e-51 hypothetical protein TcasGA2_TC005430 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07260 Progressive ankylosis protein (ANKH) GO:0035435//GO:0006817 phosphate ion transmembrane transport//phosphate ion transport GO:0015114 phosphate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.20590 BF_2 242.39 6.92 1752 91089285 XP_970985.1 1201 6.2e-129 PREDICTED: cytoplasmic phosphatidylinositol transfer protein 1 [Tribolium castaneum]>gi|270011448|gb|EFA07896.1| hypothetical protein TcasGA2_TC005471 [Tribolium castaneum] 572257887 XM_006607277.1 135 7.07774e-62 PREDICTED: Apis dorsata cytoplasmic phosphatidylinositol transfer protein 1-like (LOC102673968), mRNA -- -- -- -- Q9U9P7 1028 2.9e-110 Cytoplasmic phosphatidylinositol transfer protein 1 OS=Drosophila melanogaster GN=rdgBbeta PE=2 SV=1 PF02121 Phosphatidylinositol transfer protein GO:0006810 transport -- -- GO:0005622 intracellular KOG3668 Phosphatidylinositol transfer protein Cluster-8309.20591 BF_2 19.00 3.37 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20594 BF_2 95.47 0.66 6298 91094947 XP_968721.1 2301 6.2e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF16752//PF02295//PF15460//PF06815 Tubulin-specific chaperone C N-terminal domain//Adenosine deaminase z-alpha domain//Something about silencing, SAS, complex subunit 4//Reverse transcriptase connection domain GO:0006278//GO:0016573//GO:0006807 RNA-dependent DNA replication//histone acetylation//nitrogen compound metabolic process GO:0015631//GO:0003723//GO:0003964//GO:0003726 tubulin binding//RNA binding//RNA-directed DNA polymerase activity//double-stranded RNA adenosine deaminase activity GO:0045298 tubulin complex KOG2432 Uncharacterized conserved protein Cluster-8309.20595 BF_2 64.25 1.41 2195 642916064 XP_970366.3 2023 3.7e-224 PREDICTED: twinkle protein, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17680 PEO1 twinkle protein http://www.genome.jp/dbget-bin/www_bget?ko:K17680 Q96RR1 1141 2.9e-123 Twinkle protein, mitochondrial OS=Homo sapiens GN=PEO1 PE=1 SV=1 PF03193//PF00005//PF06009//PF03796//PF01637//PF00437 Protein of unknown function, DUF258//ABC transporter//Laminin Domain II//DnaB-like helicase C terminal domain//Archaeal ATPase//Type II/IV secretion system protein GO:0006810//GO:0006260//GO:0007155 transport//DNA replication//cell adhesion GO:0005524//GO:0003678//GO:0003924//GO:0016887//GO:0005525 ATP binding//DNA helicase activity//GTPase activity//ATPase activity//GTP binding GO:0005657 replication fork KOG2373 Predicted mitochondrial DNA helicase twinkle Cluster-8309.20596 BF_2 16.30 0.62 1389 91088447 XP_968769.1 788 3.8e-81 PREDICTED: PI-PLC X domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270012211|gb|EFA08659.1| hypothetical protein TcasGA2_TC006324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58EK3 449 3.2e-43 PI-PLC X domain-containing protein 3 OS=Danio rerio GN=plcxd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4306 Glycosylphosphatidylinositol-specific phospholipase C Cluster-8309.20597 BF_2 161.04 7.03 1246 91088447 XP_968769.1 946 1.6e-99 PREDICTED: PI-PLC X domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270012211|gb|EFA08659.1| hypothetical protein TcasGA2_TC006324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58EK3 556 1.1e-55 PI-PLC X domain-containing protein 3 OS=Danio rerio GN=plcxd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4306 Glycosylphosphatidylinositol-specific phospholipase C Cluster-8309.20599 BF_2 1.00 3.86 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2060 BF_2 22.05 0.31 3273 478262642 ENN81206.1 633 8.5e-63 hypothetical protein YQE_02396, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4V7Q6 369 1.4e-33 Serine/threonine-protein kinase ULK3 OS=Xenopus laevis GN=ulk3 PE=2 SV=1 PF02740//PF06293//PF00069//PF08502//PF07714//PF03829//PF05445 Colipase, C-terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//LeuA allosteric (dimerisation) domain//Protein tyrosine kinase//PTS system glucitol/sorbitol-specific IIA component//Poxvirus serine/threonine protein kinase GO:0016042//GO:0008643//GO:0006090//GO:0009401//GO:0009099//GO:0009097//GO:0009098//GO:0006468//GO:0007586 lipid catabolic process//carbohydrate transport//pyruvate metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//valine biosynthetic process//isoleucine biosynthetic process//leucine biosynthetic process//protein phosphorylation//digestion GO:0016773//GO:0008047//GO:0008982//GO:0004672//GO:0003852//GO:0005524 phosphotransferase activity, alcohol group as acceptor//enzyme activator activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase activity//2-isopropylmalate synthase activity//ATP binding GO:0005576//GO:0016020//GO:0009357//GO:0005737 extracellular region//membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//cytoplasm -- -- Cluster-8309.20601 BF_2 165.12 4.16 1946 91088343 XP_971105.1 792 1.8e-81 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 594 6.9e-60 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF08720//PF00106//PF01370//PF02558//PF02826//PF02882//PF12242 Influenza C hemagglutinin stalk//short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0015940//GO:0007165//GO:0009396//GO:0046487//GO:0055114//GO:0008152//GO:0019064 pantothenate biosynthetic process//signal transduction//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//oxidation-reduction process//metabolic process//fusion of virus membrane with host plasma membrane GO:0050662//GO:0004488//GO:0003824//GO:0016491//GO:0051287//GO:0008677//GO:0046789 coenzyme binding//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//oxidoreductase activity//NAD binding//2-dehydropantoate 2-reductase activity//host cell surface receptor binding GO:0019031//GO:0009986 viral envelope//cell surface KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.20602 BF_2 38.56 0.67 2680 642916504 XP_008191070.1 943 7.8e-99 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum]>gi|270003609|gb|EFA00057.1| hypothetical protein TcasGA2_TC002865 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 283 1.1e-23 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF05192//PF02052//PF00560//PF01484 Leucine rich repeat//MutS domain III//Gallidermin//Leucine Rich Repeat//Nematode cuticle collagen N-terminal domain GO:0006298//GO:0042742 mismatch repair//defense response to bacterium GO:0005524//GO:0030983//GO:0005515//GO:0042302 ATP binding//mismatched DNA binding//protein binding//structural constituent of cuticle GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.20605 BF_2 41.44 0.71 2736 642916504 XP_008191070.1 943 8.0e-99 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum]>gi|270003609|gb|EFA00057.1| hypothetical protein TcasGA2_TC002865 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 283 1.1e-23 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF02052//PF05192//PF13855//PF00001//PF00560//PF01484 Gallidermin//MutS domain III//Leucine rich repeat//7 transmembrane receptor (rhodopsin family)//Leucine Rich Repeat//Nematode cuticle collagen N-terminal domain GO:0042742//GO:0006298//GO:0007186 defense response to bacterium//mismatch repair//G-protein coupled receptor signaling pathway GO:0005515//GO:0042302//GO:0004930//GO:0005524//GO:0030983 protein binding//structural constituent of cuticle//G-protein coupled receptor activity//ATP binding//mismatched DNA binding GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.20609 BF_2 384.00 23.77 963 91083047 XP_966461.1 849 2.2e-88 PREDICTED: gamma-secretase subunit Aph-1 [Tribolium castaneum]>gi|270007655|gb|EFA04103.1| hypothetical protein TcasGA2_TC014338 [Tribolium castaneum] -- -- -- -- -- K06172 APH1 anterior pharynx defective 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06172 Q9VQG2 651 8.4e-67 Gamma-secretase subunit Aph-1 OS=Drosophila melanogaster GN=aph-1 PE=1 SV=1 PF06105 Aph-1 protein GO:0043085//GO:0016485 positive regulation of catalytic activity//protein processing -- -- GO:0016021 integral component of membrane KOG3972 Predicted membrane protein Cluster-8309.20611 BF_2 310.00 8.67 1783 646712116 KDR17021.1 949 1.0e-99 CRAL-TRIO domain-containing protein C3H8.02 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q10138 236 2.0e-18 CRAL-TRIO domain-containing protein C3H8.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC3H8.02 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1470 Phosphatidylinositol transfer protein PDR16 and related proteins Cluster-8309.20613 BF_2 29.74 0.89 1685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05625 PAXNEB protein -- -- -- -- GO:0033588 Elongator holoenzyme complex -- -- Cluster-8309.20614 BF_2 103.39 0.85 5377 270014663 EFA11111.1 4795 0.0e+00 hypothetical protein TcasGA2_TC004709 [Tribolium castaneum] -- -- -- -- -- K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 P31696 1106 8.1e-119 Agrin OS=Gallus gallus GN=AGRN PE=1 SV=3 PF00008//PF07648//PF00050 EGF-like domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.20615 BF_2 44.72 0.77 2720 478253744 ENN74040.1 2544 1.8e-284 hypothetical protein YQE_09365, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.20616 BF_2 34.63 0.57 2844 478253744 ENN74040.1 2298 6.3e-256 hypothetical protein YQE_09365, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00036//PF13405//PF13833//PF13499 EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.20617 BF_2 2.00 2.53 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20618 BF_2 21.00 3.99 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2062 BF_2 17.00 0.69 1324 665818199 XP_008557915.1 159 3.1e-08 PREDICTED: tigger transposable element-derived protein 4-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20620 BF_2 23.20 0.67 1732 642929239 XP_008195748.1 325 2.3e-27 PREDICTED: uncharacterized protein LOC103313667 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284//PF01914 Membrane-associating domain//MarC family integral membrane protein -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.20622 BF_2 147.29 1.26 5165 642916148 XP_008190905.1 4378 0.0e+00 PREDICTED: BAI1-associated protein 3 [Tribolium castaneum]>gi|270003708|gb|EFA00156.1| hypothetical protein TcasGA2_TC002977 [Tribolium castaneum] 642916147 XM_008192683.1 881 0 PREDICTED: Tribolium castaneum BAI1-associated protein 3 (LOC661754), mRNA K15621 BAIAP3 BAI1-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15621 O94812 1237 5.0e-134 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF08361//PF00168//PF01779 MAATS-type transcriptional repressor, C-terminal region//C2 domain//Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003677//GO:0003735//GO:0005515 DNA binding//structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.20623 BF_2 4901.00 255.05 1091 336444988 AEI58591.1 631 4.8e-63 serine protease [Eupolyphaga sinensis] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P35037 522 8.6e-52 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089//PF00706 Trypsin//Anenome neurotoxin GO:0006508//GO:0009966 proteolysis//regulation of signal transduction GO:0004252 serine-type endopeptidase activity GO:0005576 extracellular region -- -- Cluster-8309.20627 BF_2 64.90 0.49 5868 642924788 XP_008194040.1 1819 4.5e-200 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 990 2.5e-105 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF01554//PF00989//PF08447 MatE//PAS fold//PAS fold GO:0006810//GO:0006855//GO:0055085//GO:0015893//GO:0006355 transport//drug transmembrane transport//transmembrane transport//drug transport//regulation of transcription, DNA-templated GO:0015238//GO:0005515//GO:0015297 drug transmembrane transporter activity//protein binding//antiporter activity GO:0016020 membrane KOG3753 Circadian clock protein period Cluster-8309.20629 BF_2 48.16 0.77 2890 91078706 XP_971901.1 1958 1.7e-216 PREDICTED: putative RNA exonuclease NEF-sp [Tribolium castaneum]>gi|270003754|gb|EFA00202.1| hypothetical protein TcasGA2_TC003027 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q4R9F7 466 7.1e-45 Putative RNA exonuclease NEF-sp OS=Macaca fascicularis GN=QtsA-10054 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2248 3'-5' exonuclease Cluster-8309.20631 BF_2 11.00 0.63 1019 646723359 KDR23993.1 167 2.9e-09 hypothetical protein L798_07932, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20633 BF_2 1228.40 29.95 2003 270006188 EFA02636.1 1626 3.7e-178 hypothetical protein TcasGA2_TC008357 [Tribolium castaneum] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 O16098 1328 5.5e-145 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128//PF02284 Alpha amylase, catalytic domain//Cytochrome c oxidase subunit Va GO:0006123//GO:0015992//GO:0005975 mitochondrial electron transport, cytochrome c to oxygen//proton transport//carbohydrate metabolic process GO:0003824//GO:0004129//GO:0043169 catalytic activity//cytochrome-c oxidase activity//cation binding GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane -- -- Cluster-8309.20635 BF_2 12.86 0.42 1582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20636 BF_2 139.40 2.44 2680 759041178 XP_011329400.1 2003 9.5e-222 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Cerapachys biroi] 195434173 XM_002065042.1 152 3.86368e-71 Drosophila willistoni GK15268 (Dwil\GK15268), mRNA K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 1145 1.2e-123 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF02065//PF16499 Melibiase//Alpha galactosidase A GO:0006012//GO:0001575//GO:0046486//GO:0005975 galactose metabolic process//globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0004553//GO:0004557 hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-galactosidase activity -- -- KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.20641 BF_2 153.00 14.07 742 478254316 ENN74570.1 316 1.1e-26 hypothetical protein YQE_08892, partial [Dendroctonus ponderosae]>gi|546674045|gb|ERL85533.1| hypothetical protein D910_02952 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20642 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20651 BF_2 1.00 31.42 207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20653 BF_2 2.00 0.36 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20655 BF_2 36.00 1.73 1158 857971552 CEP02046.1 823 2.8e-85 hypothetical protein PBRA_002311 [Plasmodiophora brassicae] 731413796 XM_010660590.1 625 0 PREDICTED: Vitis vinifera dnaJ protein homolog (LOC100233131), transcript variant X2, mRNA K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 Q04960 1369 5.6e-150 DnaJ protein homolog OS=Cucumis sativus GN=DNAJ1 PE=2 SV=1 PF04666//PF00684//PF16685//PF01155 N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region//DnaJ central domain//zinc RING finger of MSL2//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0005975//GO:0006464 carbohydrate metabolic process//cellular protein modification process GO:0051082//GO:0061630//GO:0016151//GO:0031072//GO:0016758 unfolded protein binding//ubiquitin protein ligase activity//nickel cation binding//heat shock protein binding//transferase activity, transferring hexosyl groups GO:0016020 membrane KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.20656 BF_2 31.00 0.36 3894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20657 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20664 BF_2 32.40 0.53 2855 189235321 XP_975176.2 585 2.7e-57 PREDICTED: methyltransferase-like protein 22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1C6 182 6.0e-12 Methyltransferase-like protein 22 OS=Mus musculus GN=Mettl22 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20665 BF_2 28.30 0.95 1537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01783 Ribosomal L32p protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome -- -- Cluster-8309.20666 BF_2 502.84 17.62 1481 270007404 EFA03852.1 426 3.9e-39 hypothetical protein TcasGA2_TC013968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01402 Ribbon-helix-helix protein, copG family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.20667 BF_2 276.00 38.25 589 546684200 ERL93905.1 567 6.8e-56 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09360 Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.20669 BF_2 34.26 0.39 3925 270003759 EFA00207.1 1160 7.9e-124 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.68205e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.20671 BF_2 219.57 1.62 5959 642923511 XP_008193539.1 1818 6.0e-200 PREDICTED: pH-response transcription factor pacC/RIM101-like isoform X1 [Tribolium castaneum]>gi|270006994|gb|EFA03442.1| hypothetical protein TcasGA2_TC013432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14872 837 1.4e-87 Metal regulatory transcription factor 1 OS=Homo sapiens GN=MTF1 PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.20672 BF_2 8.01 0.39 1138 642928984 XP_008195645.1 726 4.8e-74 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 495 1.2e-48 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF00232//PF05038 Glycosyl hydrolase family 1//Cytochrome Cytochrome b558 alpha-subunit GO:0005975//GO:0008152 carbohydrate metabolic process//metabolic process GO:0020037//GO:0004553//GO:0016798 heme binding//hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity, acting on glycosyl bonds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.20673 BF_2 70.76 1.47 2306 189236990 XP_970274.2 792 2.2e-81 PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|642921800|ref|XP_008199324.1| PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|270008114|gb|EFA04562.1| hypothetical protein TcasGA2_TC010947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZS10 145 9.5e-08 C-type lectin domain family 17, member A OS=Homo sapiens GN=CLEC17A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20674 BF_2 150.92 0.71 9204 642911642 XP_008200683.1 12643 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurofibromin [Tribolium castaneum] 751776924 XM_011199144.1 429 0 PREDICTED: Bactrocera dorsalis neurofibromin (LOC105221988), mRNA K08052 NF1 neurofibromin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08052 P97526 5995 0.0e+00 Neurofibromin OS=Rattus norvegicus GN=Nf1 PE=1 SV=1 PF09090//PF00616//PF12356 MIF4G like//GTPase-activator protein for Ras-like GTPase//Protein of unknown function (DUF3643) GO:0016070//GO:0006915//GO:0032465//GO:0016567//GO:0043087 RNA metabolic process//apoptotic process//regulation of cytokinesis//protein ubiquitination//regulation of GTPase activity GO:0004842 ubiquitin-protein transferase activity -- -- KOG1826 Ras GTPase activating protein RasGAP/neurofibromin Cluster-8309.20676 BF_2 1.00 0.65 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20678 BF_2 4.10 0.48 645 642920261 XP_008192272.1 164 4.0e-09 PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920263|ref|XP_008192273.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920265|ref|XP_008192274.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920267|ref|XP_008192275.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|270005277|gb|EFA01725.1| hypothetical protein TcasGA2_TC007305 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0006811//GO:0008283//GO:0007165//GO:0040007 ion transport//cell proliferation//signal transduction//growth GO:0005216//GO:0008083 ion channel activity//growth factor activity GO:0016021 integral component of membrane -- -- Cluster-8309.20683 BF_2 34.00 2.07 975 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20687 BF_2 34.19 0.74 2210 549438519 AGX25148.1 1757 2.6e-193 beta-glucuronidase-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 883 2.4e-93 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF00703//PF02837//PF02836 Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain//Glycosyl hydrolases family 2, TIM barrel domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.20688 BF_2 43.39 2.09 1156 642928984 XP_008195645.1 1014 2.0e-107 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 710 1.4e-73 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF02226//PF00232 Picornavirus coat protein (VP4)//Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0016787//GO:0004553//GO:0005198 hydrolase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//structural molecule activity GO:0019028 viral capsid KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.20689 BF_2 44.00 1.67 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20690 BF_2 487.81 10.00 2328 91079360 XP_970234.1 2690 1.8e-301 PREDICTED: armadillo repeat-containing protein 8 [Tribolium castaneum]>gi|270004363|gb|EFA00811.1| hypothetical protein TcasGA2_TC003698 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBR3 1449 5.9e-159 Armadillo repeat-containing protein 8 OS=Mus musculus GN=Armc8 PE=2 SV=2 PF04869//PF02985//PF11698//PF00514 Uso1 / p115 like vesicle tethering protein, head region//HEAT repeat//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015991//GO:0006886//GO:0048280 ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle fusion with Golgi apparatus GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221//GO:0000139//GO:0005737 vacuolar proton-transporting V-type ATPase, V1 domain//Golgi membrane//cytoplasm -- -- Cluster-8309.20692 BF_2 11.76 0.71 984 91094721 XP_970562.1 549 1.4e-53 PREDICTED: solute carrier family 22 member 1 [Tribolium castaneum]>gi|270016527|gb|EFA12973.1| hypothetical protein TcasGA2_TC010997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75751 156 2.1e-09 Solute carrier family 22 member 3 OS=Homo sapiens GN=SLC22A3 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.20694 BF_2 109.70 2.77 1944 642920143 XP_008192222.1 2144 3.1e-238 PREDICTED: arylsulfatase B [Tribolium castaneum]>gi|270005303|gb|EFA01751.1| hypothetical protein TcasGA2_TC007349 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 Q5FYB0 906 4.6e-96 Arylsulfatase J OS=Homo sapiens GN=ARSJ PE=2 SV=1 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.20695 BF_2 55.89 1.46 1884 642920143 XP_008192222.1 2045 9.1e-227 PREDICTED: arylsulfatase B [Tribolium castaneum]>gi|270005303|gb|EFA01751.1| hypothetical protein TcasGA2_TC007349 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50429 952 2.0e-101 Arylsulfatase B OS=Mus musculus GN=Arsb PE=2 SV=3 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.20698 BF_2 1.00 1.13 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20701 BF_2 7.18 0.44 974 642914271 XP_008201616.1 451 3.2e-42 PREDICTED: sulfiredoxin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12260 SRX1 sulfiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K12260 Q9D975 333 6.3e-30 Sulfiredoxin-1 OS=Mus musculus GN=Srxn1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3388 Predicted transcription regulator/nuclease, contains ParB domain Cluster-8309.20705 BF_2 47.00 0.81 2724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20706 BF_2 500.42 15.77 1615 642924852 XP_008194066.1 1218 6.1e-131 PREDICTED: nuclear migration protein nudC [Tribolium castaneum] 642924851 XM_008195844.1 207 6.15463e-102 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- O35685 811 3.9e-85 Nuclear migration protein nudC OS=Mus musculus GN=Nudc PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.20707 BF_2 8.91 1.13 616 121531590 ABM55480.1 362 4.2e-32 digestive cysteine protease intestain [Leptinotarsa decemlineata] -- -- -- -- -- K01368 CTSS cathepsin S http://www.genome.jp/dbget-bin/www_bget?ko:K01368 O97397 305 7.1e-27 Cathepsin L-like proteinase OS=Phaedon cochleariae PE=2 SV=1 PF00112 Papain family cysteine protease GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.20709 BF_2 521.22 9.97 2473 189238821 XP_968538.2 947 2.5e-99 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|642927448|ref|XP_008195277.1| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|270010156|gb|EFA06604.1| hypothetical protein TcasGA2_TC009519 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 455 1.1e-43 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF13184//PF13014//PF00013//PF07650 NusA-like KH domain//KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.20711 BF_2 6.90 1.27 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20713 BF_2 3.00 1.04 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0055114//GO:0006570 obsolete electron transport//oxidation-reduction process//tyrosine metabolic process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.20714 BF_2 2.00 1.95 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20715 BF_2 63.00 2.16 1506 642934687 XP_008197771.1 391 4.5e-35 PREDICTED: uncharacterized protein C6orf203 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQF4 170 7.8e-11 Uncharacterized protein C6orf203 homolog OS=Mus musculus PE=1 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.20716 BF_2 22.97 0.34 3142 642920491 XP_008192374.1 1783 3.6e-196 PREDICTED: acyl-CoA synthetase family member 4 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLL0 759 8.2e-79 Acyl-CoA synthetase family member 4 homolog OS=Drosophila melanogaster GN=U26 PE=2 SV=3 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.20717 BF_2 69.00 0.81 3855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20720 BF_2 241.12 6.10 1942 546680883 ERL91069.1 1013 4.3e-107 hypothetical protein D910_08411 [Dendroctonus ponderosae] -- -- -- -- -- K14458 MOGAT1, MGAT1 2-acylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14458 Q70VZ7 706 7.1e-73 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.20721 BF_2 669.00 27.63 1300 270014250 EFA10698.1 518 7.3e-50 serine protease P128 [Tribolium castaneum] -- -- -- -- -- K01310 CTRB chymotrypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01310 Q00871 471 8.4e-46 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20727 BF_2 133.00 4.86 1432 478260798 ENN80458.1 1324 2.8e-143 hypothetical protein YQE_03115, partial [Dendroctonus ponderosae]>gi|546673402|gb|ERL85014.1| hypothetical protein D910_02437 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O95801 578 3.6e-58 Tetratricopeptide repeat protein 4 OS=Homo sapiens GN=TTC4 PE=1 SV=3 PF00515//PF13374//PF13181//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG0551 Hsp90 co-chaperone CNS1 (contains TPR repeats) Cluster-8309.20732 BF_2 2.00 0.72 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20733 BF_2 115.00 18.51 547 86279291 ABC88741.1 294 2.9e-24 putative serine proteinase [Tenebrio molitor] -- -- -- -- -- K01353 GZMB granzyme B http://www.genome.jp/dbget-bin/www_bget?ko:K01353 O97398 280 5.0e-24 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20734 BF_2 13.00 6.43 369 86279289 ABC88740.1 243 1.6e-18 putative serine proteinase [Tenebrio molitor] -- -- -- -- -- -- -- -- -- O97398 202 3.7e-15 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20736 BF_2 14.84 0.44 1683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20738 BF_2 8.00 0.45 1038 546676115 ERL87182.1 192 3.7e-12 hypothetical protein D910_04582 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20743 BF_2 11.14 0.36 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20744 BF_2 2.75 0.33 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20746 BF_2 32.64 3.21 713 -- -- -- -- -- 23495780 AP003963.3 713 0 Oryza sativa Japonica Group genomic DNA, chromosome 7, BAC clone:OJ1779_B07 -- -- -- -- Q01881 779 8.9e-82 Seed allergenic protein RA5 OS=Oryza sativa subsp. japonica GN=RA5 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20747 BF_2 74.00 9.47 614 -- -- -- -- -- 156764657 AK288042.1 611 0 Oryza sativa Japonica Group cDNA, clone: J075144H05, full insert sequence -- -- -- -- P17048 332 5.2e-30 13 kDa prolamin C OS=Oryza sativa subsp. japonica GN=PROLM25 PE=2 SV=2 PF02884 Polysaccharide lyase family 8, C-terminal beta-sandwich domain -- -- GO:0016829 lyase activity GO:0005576 extracellular region -- -- Cluster-8309.20749 BF_2 73.59 1.86 1943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20750 BF_2 115.00 3.21 1787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08273 Zinc-binding domain of primase-helicase GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896//GO:0008270//GO:0004386 DNA primase activity//zinc ion binding//helicase activity GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.20751 BF_2 152.75 2.03 3432 642931117 XP_008201668.1 644 4.7e-64 PREDICTED: autism susceptibility gene 2 protein isoform X3 [Tribolium castaneum] 642931120 XM_008203448.1 181 3.75575e-87 PREDICTED: Tribolium castaneum autism susceptibility gene 2 protein (LOC655697), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF06273 Plant specific eukaryotic initiation factor 4B GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.20753 BF_2 65.00 2146.38 206 -- -- -- -- -- 729343202 XM_010542530.1 44 2.77143e-12 PREDICTED: Tarenaya hassleriana uncharacterized LOC104814477 (LOC104814477), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20754 BF_2 1066.86 35.97 1528 748995286 AJE75665.1 1597 6.5e-175 putative glycosyl hydrolase [Chrysomela lapponica] 748995287 KP068695.1 35 2.39264e-06 Chrysomela lapponica isolate ClGH8 putative glycosyl hydrolase mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 1154 6.3e-125 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF00232//PF02788//PF00150 Glycosyl hydrolase family 1//Ribulose bisphosphate carboxylase large chain, N-terminal domain//Cellulase (glycosyl hydrolase family 5) GO:0046487//GO:0005975//GO:0015977 glyoxylate metabolic process//carbohydrate metabolic process//carbon fixation GO:0016984//GO:0004553 ribulose-bisphosphate carboxylase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009573 chloroplast ribulose bisphosphate carboxylase complex KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.2076 BF_2 29.00 0.46 2944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04902//PF01754//PF00041 Conserved region in Nab1//A20-like zinc finger//Fibronectin type III domain GO:0045892 negative regulation of transcription, DNA-templated GO:0003677//GO:0008270//GO:0005515 DNA binding//zinc ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.20760 BF_2 13.00 1.69 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20763 BF_2 7.14 0.41 1019 91092754 XP_973448.1 653 1.3e-65 PREDICTED: Werner Syndrome-like exonuclease [Tribolium castaneum]>gi|270014889|gb|EFA11337.1| hypothetical protein TcasGA2_TC010877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4PLB3 482 3.5e-47 Werner Syndrome-like exonuclease OS=Drosophila yakuba GN=WRNexo PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.20768 BF_2 664.20 3.37 8520 478256070 ENN76269.1 1358 1.9e-146 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 268 1.9e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF06220//PF06657//PF00769//PF01025//PF00866//PF03623//PF05837//PF01008//PF10473//PF04508//PF01576//PF00170//PF16331//PF07851//PF04111 U1 zinc finger//Centrosome microtubule-binding domain of Cep57//Ezrin/radixin/moesin family//GrpE//Ring hydroxylating beta subunit//Focal adhesion targeting region//Centromere protein H (CENP-H)//Initiation factor 2 subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Viral A-type inclusion protein repeat//Myosin tail//bZIP transcription factor//TolA binding protein trimerisation//TMPIT-like protein//Autophagy protein Apg6 GO:0006725//GO:0007172//GO:0016032//GO:0055114//GO:0044237//GO:0051382//GO:0006457//GO:0006355//GO:0070206//GO:0006468//GO:0006914//GO:0007165 cellular aromatic compound metabolic process//signal complex assembly//viral process//oxidation-reduction process//cellular metabolic process//kinetochore assembly//protein folding//regulation of transcription, DNA-templated//protein trimerization//protein phosphorylation//autophagy//signal transduction GO:0003774//GO:0008092//GO:0003700//GO:0051087//GO:0008134//GO:0045502//GO:0004871//GO:0008017//GO:0042803//GO:0004713//GO:0003824//GO:0000774//GO:0043565//GO:0008270 motor activity//cytoskeletal protein binding//transcription factor activity, sequence-specific DNA binding//chaperone binding//transcription factor binding//dynein binding//signal transducer activity//microtubule binding//protein homodimerization activity//protein tyrosine kinase activity//catalytic activity//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//zinc ion binding GO:0000776//GO:0005667//GO:0030286//GO:0045298//GO:0005925//GO:0019898//GO:0005737//GO:0016459//GO:0016021 kinetochore//transcription factor complex//dynein complex//tubulin complex//focal adhesion//extrinsic component of membrane//cytoplasm//myosin complex//integral component of membrane -- -- Cluster-8309.20769 BF_2 3.00 0.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20773 BF_2 15.05 0.48 1588 478249712 ENN70220.1 1482 1.5e-161 hypothetical protein YQE_13006, partial [Dendroctonus ponderosae] -- -- -- -- -- K03514 PAPD5_7, TRF4 non-canonical poly(A) RNA polymerase PAPD5/7 http://www.genome.jp/dbget-bin/www_bget?ko:K03514 Q68ED3 990 6.8e-106 Non-canonical poly(A) RNA polymerase PAPD5 OS=Mus musculus GN=Papd5 PE=1 SV=2 PF01909 Nucleotidyltransferase domain -- -- GO:0016779 nucleotidyltransferase activity -- -- KOG1906 DNA polymerase sigma Cluster-8309.20774 BF_2 320.40 7.84 1997 478249712 ENN70220.1 1666 8.5e-183 hypothetical protein YQE_13006, partial [Dendroctonus ponderosae] -- -- -- -- -- K03514 PAPD5_7, TRF4 non-canonical poly(A) RNA polymerase PAPD5/7 http://www.genome.jp/dbget-bin/www_bget?ko:K03514 Q68ED3 1086 6.3e-117 Non-canonical poly(A) RNA polymerase PAPD5 OS=Mus musculus GN=Papd5 PE=1 SV=2 PF01909 Nucleotidyltransferase domain -- -- GO:0016779 nucleotidyltransferase activity -- -- KOG1906 DNA polymerase sigma Cluster-8309.20776 BF_2 8.00 1.24 556 -- -- -- -- -- 221554531 NG_009445.1 556 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20777 BF_2 20.70 0.32 2978 189238125 XP_001814215.1 3142 0.0e+00 PREDICTED: phagocyte signaling-impaired protein [Tribolium castaneum]>gi|270008817|gb|EFA05265.1| hypothetical protein TcasGA2_TC015420 [Tribolium castaneum] 462295253 APGK01052815.1 38 1.01306e-07 Dendroctonus ponderosae Seq01052825, whole genome shotgun sequence K17973 NAA25, MDM20 N-terminal acetyltransferase B complex non-catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17973 Q17DK2 1553 6.6e-171 Phagocyte signaling-impaired protein OS=Aedes aegypti GN=psidin PE=3 SV=2 PF14863//PF13414 Alkyl sulfatase dimerisation//TPR repeat -- -- GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG2053 Mitochondrial inheritance and actin cytoskeleton organization protein Cluster-8309.2078 BF_2 4.00 0.65 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20780 BF_2 63.70 3.31 1093 642910247 XP_008198549.1 624 3.1e-62 PREDICTED: protein pygopus isoform X3 [Tribolium castaneum]>gi|270014625|gb|EFA11073.1| hypothetical protein TcasGA2_TC004669 [Tribolium castaneum] 241695262 XM_002412985.1 132 2.03164e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 427 9.0e-41 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF17123//PF00628//PF13639 RING-like zinc finger//PHD-finger//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.20781 BF_2 13.46 0.49 1429 91090526 XP_970144.1 430 1.3e-39 PREDICTED: UBX domain-containing protein 1 [Tribolium castaneum]>gi|270013875|gb|EFA10323.1| hypothetical protein TcasGA2_TC012540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GL77 271 1.4e-22 UBX domain-containing protein 1 OS=Xenopus tropicalis GN=ubxn1 PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG2689 Predicted ubiquitin regulatory protein Cluster-8309.20783 BF_2 95.00 7.83 795 675364664 KFM57566.1 422 6.0e-39 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q53H47 179 3.7e-12 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.20785 BF_2 4.00 0.44 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20786 BF_2 91.69 3.71 1320 642928238 XP_008195500.1 673 7.8e-68 PREDICTED: uncharacterized protein LOC103313603 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DCX1 129 3.9e-06 MAD2L1-binding protein OS=Mus musculus GN=Mad2l1bp PE=2 SV=2 PF06581 Mad1 and Cdc20-bound-Mad2 binding GO:0007096 regulation of exit from mitosis -- -- GO:0005634 nucleus -- -- Cluster-8309.20787 BF_2 1220.51 22.93 2514 270297172 NP_001161926.1 452 6.3e-42 peritrophic matrix protein 9 precursor [Tribolium castaneum]>gi|268309044|gb|ACY95488.1| peritrophic matrix protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W5U2 225 5.5e-17 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.20789 BF_2 138.38 7.81 1028 478257312 ENN77472.1 452 2.6e-42 hypothetical protein YQE_06000, partial [Dendroctonus ponderosae]>gi|546679541|gb|ERL89989.1| hypothetical protein D910_07348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock -- -- -- -- -- -- Cluster-8309.20790 BF_2 787.94 9.83 3640 270297184 NP_001161900.1 836 2.7e-86 cuticular protein analogous to peritrophins 1-I precursor [Tribolium castaneum]>gi|268373732|gb|ACZ04319.1| CPAP1-I [Tribolium castaneum]>gi|270014341|gb|EFA10789.1| hypothetical protein TcasGA2_TC012766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.20795 BF_2 4.00 14.96 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20796 BF_2 41.48 0.52 3615 642926822 XP_008195028.1 2075 5.8e-230 PREDICTED: pre-mRNA-processing factor 40 homolog A [Tribolium castaneum]>gi|270009175|gb|EFA05623.1| hypothetical protein TcasGA2_TC015831 [Tribolium castaneum] 642926821 XM_008196806.1 279 1.31702e-141 PREDICTED: Tribolium castaneum pre-mRNA-processing factor 40 homolog A (LOC658510), mRNA K12821 PRPF40, PRP40 pre-mRNA-processing factor 40 http://www.genome.jp/dbget-bin/www_bget?ko:K12821 Q6NWY9 1215 1.3e-131 Pre-mRNA-processing factor 40 homolog B OS=Homo sapiens GN=PRPF40B PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0152 Spliceosomal protein FBP11/Splicing factor PRP40 Cluster-8309.2080 BF_2 4.00 0.42 688 18916919 BAB85575.1 607 1.8e-60 cyclic AMP-regulated protein like protein [Marsupenaeus japonicus] -- -- -- -- -- -- -- -- -- Q2HJ57 354 1.6e-32 Coactosin-like protein OS=Bos taurus GN=COTL1 PE=2 SV=3 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular -- -- Cluster-8309.20800 BF_2 393.00 9.80 1964 642921456 XP_008192875.1 1513 4.6e-165 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VD19 713 1.1e-73 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.20801 BF_2 13.00 36.47 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20802 BF_2 162.56 4.55 1781 642937581 XP_008199107.1 1199 1.1e-128 PREDICTED: zinc finger and BTB domain-containing protein 12-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B87 360 8.6e-33 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20803 BF_2 3.00 0.58 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20805 BF_2 28.81 0.72 1957 478260139 ENN79924.1 158 6.1e-08 hypothetical protein YQE_03743, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20813 BF_2 36.66 2.08 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20816 BF_2 128.49 3.84 1687 642910324 XP_008200283.1 1126 3.0e-120 PREDICTED: serologically defined colon cancer antigen 3 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIW0 245 1.8e-19 Serologically defined colon cancer antigen 3 homolog OS=Mus musculus GN=Sdccag3 PE=2 SV=1 PF04632//PF06156//PF04111//PF06009//PF16867//PF01496 Fusaric acid resistance protein family//Protein of unknown function (DUF972)//Autophagy protein Apg6//Laminin Domain II//Dimethlysulfonioproprionate lyase//V-type ATPase 116kDa subunit family GO:0015992//GO:0007155//GO:0006260//GO:0006914//GO:0015991//GO:0006810 proton transport//cell adhesion//DNA replication//autophagy//ATP hydrolysis coupled proton transport//transport GO:0047869//GO:0015078 dimethylpropiothetin dethiomethylase activity//hydrogen ion transmembrane transporter activity GO:0033179//GO:0005886 proton-transporting V-type ATPase, V0 domain//plasma membrane -- -- Cluster-8309.20818 BF_2 124.87 3.18 1931 642914834 XP_008194983.1 1326 2.2e-143 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 91 2.25127e-37 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q9NXR8 712 1.4e-73 Inhibitor of growth protein 3 OS=Homo sapiens GN=ING3 PE=1 SV=2 PF00628//PF12090//PF03153//PF00160//PF10280 PHD-finger//Spt20 family//Transcription factor IIA, alpha/beta subunit//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Mediator complex protein GO:0006457//GO:0006357//GO:0006367//GO:0000413 protein folding//regulation of transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//protein peptidyl-prolyl isomerization GO:0001104//GO:0005515//GO:0003712//GO:0003755 RNA polymerase II transcription cofactor activity//protein binding//transcription cofactor activity//peptidyl-prolyl cis-trans isomerase activity GO:0016592//GO:0000124//GO:0005667//GO:0005672 mediator complex//SAGA complex//transcription factor complex//transcription factor TFIIA complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.20821 BF_2 450.19 10.64 2057 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03357//PF04472//PF06009//PF01442 Snf7//Protein of unknown function (DUF552)//Laminin Domain II//Apolipoprotein A1/A4/E domain GO:0042157//GO:0007155//GO:0000917//GO:0006869//GO:0007034 lipoprotein metabolic process//cell adhesion//barrier septum assembly//lipid transport//vacuolar transport GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.20822 BF_2 49.00 3.29 911 642923988 XP_008193959.1 788 2.5e-81 PREDICTED: collagen alpha-3(IX) chain-like [Tribolium castaneum] -- -- -- -- -- K08131 COL9A collagen, type IX, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08131 P20849 400 1.0e-37 Collagen alpha-1(IX) chain OS=Homo sapiens GN=COL9A1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20829 BF_2 101.72 3.59 1474 642938857 XP_008192816.1 843 1.7e-87 PREDICTED: uncharacterized protein LOC659130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.20830 BF_2 188.28 6.48 1503 91092412 XP_967539.1 1829 8.0e-202 PREDICTED: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [Tribolium castaneum]>gi|270004747|gb|EFA01195.1| hypothetical protein TcasGA2_TC010522 [Tribolium castaneum] -- -- -- -- -- K05542 DUS1 tRNA-dihydrouridine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05542 Q8C2P3 1090 1.6e-117 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Mus musculus GN=Dus1l PE=2 SV=1 PF00977//PF01207//PF03060//PF04309//PF01680 Histidine biosynthesis protein//Dihydrouridine synthase (Dus)//Nitronate monooxygenase//Glycerol-3-phosphate responsive antiterminator//SOR/SNZ family GO:0002943//GO:0006355//GO:0042823//GO:0009607//GO:0000105//GO:0006807//GO:0055114//GO:0008033//GO:0042819 tRNA dihydrouridine synthesis//regulation of transcription, DNA-templated//pyridoxal phosphate biosynthetic process//response to biotic stimulus//histidine biosynthetic process//nitrogen compound metabolic process//oxidation-reduction process//tRNA processing//vitamin B6 biosynthetic process GO:0018580//GO:0017150//GO:0050660 nitronate monooxygenase activity//tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.20834 BF_2 530.22 5.37 4416 642926793 XP_008195018.1 4263 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 87 8.69992e-35 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2549 3.2e-286 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01155//PF01068//PF00651//PF00023//PF01363//PF13606 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//ATP dependent DNA ligase domain//BTB/POZ domain//Ankyrin repeat//FYVE zinc finger//Ankyrin repeat GO:0006260//GO:0006310//GO:0006281//GO:0006464 DNA replication//DNA recombination//DNA repair//cellular protein modification process GO:0046872//GO:0003910//GO:0005515//GO:0016151//GO:0005524 metal ion binding//DNA ligase (ATP) activity//protein binding//nickel cation binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.20840 BF_2 21.00 0.35 2776 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20843 BF_2 321.00 9.01 1777 642935353 XP_008197978.1 397 1.1e-35 PREDICTED: uncharacterized protein LOC103314256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10152//PF05349 Predicted coiled-coil domain-containing protein (DUF2360)//GATA-type transcription activator, N-terminal GO:0045893 positive regulation of transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding GO:0071203//GO:0005634 WASH complex//nucleus -- -- Cluster-8309.20846 BF_2 10.00 0.55 1050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20848 BF_2 521.00 11.02 2264 758213866 AJO62246.1 1112 1.7e-118 sensory neuron membrane protein SNMP-2 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- B2RFN2 616 2.3e-62 Sensory neuron membrane protein 2 OS=Heliothis virescens GN=snmp2 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane KOG3776 Plasma membrane glycoprotein CD36 and related membrane receptors Cluster-8309.20849 BF_2 34.76 1.11 1603 332372766 AEE61525.1 557 2.7e-54 unknown [Dendroctonus ponderosae]>gi|478255682|gb|ENN75893.1| hypothetical protein YQE_07535, partial [Dendroctonus ponderosae]>gi|546684507|gb|ERL94142.1| hypothetical protein D910_11424 [Dendroctonus ponderosae] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q9HC24 355 2.9e-32 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.20851 BF_2 1767.44 56.27 1601 634006736 AHZ59647.1 1681 1.2e-184 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1211 1.6e-131 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.20858 BF_2 3409.20 96.83 1760 728418014 AIY68354.1 1624 5.6e-178 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 613 3.9e-62 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.20859 BF_2 99.79 3.97 1338 728418191 AIY68360.1 686 2.5e-69 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 469 1.5e-45 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.2086 BF_2 24.00 0.53 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06699//PF04703 GPI biosynthesis protein family Pig-F//FaeA-like protein GO:0006355//GO:0006506 regulation of transcription, DNA-templated//GPI anchor biosynthetic process -- -- GO:0009289//GO:0016021//GO:0005789 pilus//integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.20860 BF_2 749.75 20.79 1796 270007404 EFA03852.1 375 3.8e-33 hypothetical protein TcasGA2_TC013968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20862 BF_2 2274.97 61.05 1846 728418241 AIY68362.1 1300 2.2e-140 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 548 1.4e-54 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.20864 BF_2 1187.58 36.00 1667 91087441 XP_975685.1 259 1.0e-19 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27018 160 1.2e-09 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.20867 BF_2 207.37 4.30 2305 642934510 XP_008197694.1 2096 1.3e-232 PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|642934512|ref|XP_008197695.1| PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|270013512|gb|EFA09960.1| hypothetical protein TcasGA2_TC012117 [Tribolium castaneum] 827536207 XM_004921559.2 239 1.43836e-119 PREDICTED: Bombyx mori AP-1 complex subunit gamma-1 (LOC101742239), mRNA K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 1313 3.5e-143 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02883//PF08367//PF01602 Adaptin C-terminal domain//Peptidase M16C associated//Adaptin N terminal region GO:0006886//GO:0016192//GO:0006508//GO:0015031 intracellular protein transport//vesicle-mediated transport//proteolysis//protein transport GO:0008565 protein transporter activity GO:0030131//GO:0044431//GO:0030117 clathrin adaptor complex//Golgi apparatus part//membrane coat KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.20868 BF_2 8.53 0.44 1096 270004689 EFA01137.1 281 1.9e-22 hypothetical protein TcasGA2_TC010361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.20871 BF_2 52.39 0.64 3707 91091628 XP_970031.1 1240 3.9e-133 PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial [Tribolium castaneum] 780117224 XM_775688.3 40 9.77196e-09 PREDICTED: Strongylocentrotus purpuratus cathepsin L1 (LOC575275), mRNA K00254 DHODH, pyrD dihydroorotate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00254 P32748 1000 1.1e-106 Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Drosophila melanogaster GN=Dhod PE=2 SV=2 PF00112//PF01180//PF03051//PF15163//PF02144//PF04139//PF03060 Papain family cysteine protease//Dihydroorotate dehydrogenase//Peptidase C1-like family//Meiosis-expressed//Repair protein Rad1/Rec1/Rad17//Rad9//Nitronate monooxygenase GO:0006807//GO:0055114//GO:0000077//GO:0006508//GO:0006281 nitrogen compound metabolic process//oxidation-reduction process//DNA damage checkpoint//proteolysis//DNA repair GO:0004197//GO:0016627//GO:0008234//GO:0018580 cysteine-type endopeptidase activity//oxidoreductase activity, acting on the CH-CH group of donors//cysteine-type peptidase activity//nitronate monooxygenase activity GO:0005737//GO:0005634//GO:0030896 cytoplasm//nucleus//checkpoint clamp complex KOG1436 Dihydroorotate dehydrogenase Cluster-8309.20873 BF_2 21.00 0.86 1311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20875 BF_2 20.77 0.67 1578 270297198 NP_001161920.1 185 3.6e-11 peritrophic matrix protein 2-B precursor [Tribolium castaneum]>gi|268309034|gb|ACY95483.1| peritrophic matrix protein 2-B [Tribolium castaneum]>gi|270003976|gb|EFA00424.1| hypothetical protein TcasGA2_TC003275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.20876 BF_2 8.17 1.55 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20877 BF_2 2.00 66.04 206 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20878 BF_2 1151.00 23655.19 216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P13813 130 4.8e-07 110 kDa antigen (Fragment) OS=Plasmodium knowlesi PE=2 SV=1 PF01335//PF04904 Death effector domain//NAB conserved region 1 (NCD1) GO:0042981//GO:0045892 regulation of apoptotic process//negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.20884 BF_2 24.00 1.05 1239 91082383 XP_968748.1 684 3.9e-69 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 565 1.0e-56 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006810//GO:0006200//GO:0055085 transport//obsolete ATP catabolic process//transmembrane transport GO:0042626//GO:0005524//GO:0016887 ATPase activity, coupled to transmembrane movement of substances//ATP binding//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.20885 BF_2 9.00 3.19 404 478259687 ENN79531.1 466 2.4e-44 hypothetical protein YQE_03994, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 348 4.8e-32 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF08477//PF03193//PF00005//PF01926//PF00158//PF13304 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system GO:0007264//GO:0006355 small GTPase mediated signal transduction//regulation of transcription, DNA-templated GO:0005525//GO:0016887//GO:0003924//GO:0008134//GO:0005524 GTP binding//ATPase activity//GTPase activity//transcription factor binding//ATP binding GO:0005667 transcription factor complex -- -- Cluster-8309.20888 BF_2 180.00 14.16 819 189234617 XP_975233.2 454 1.2e-42 PREDICTED: U1 small nuclear ribonucleoprotein C [Tribolium castaneum]>gi|270001649|gb|EEZ98096.1| hypothetical protein TcasGA2_TC000509 [Tribolium castaneum] 768438731 XM_011562662.1 101 2.57411e-43 PREDICTED: Plutella xylostella U1 small nuclear ribonucleoprotein C (LOC105391209), mRNA K11095 SNRPC U1 small nuclear ribonucleoprotein C http://www.genome.jp/dbget-bin/www_bget?ko:K11095 Q16IW3 408 1.1e-38 U1 small nuclear ribonucleoprotein C OS=Aedes aegypti GN=AAEL013527 PE=3 SV=1 PF06220 U1 zinc finger -- -- GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus KOG3454 U1 snRNP-specific protein C Cluster-8309.20891 BF_2 461.80 394.05 328 835482914 AKM70276.1 145 3.3e-07 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20897 BF_2 42.06 0.84 2394 270002312 EEZ98759.1 468 8.4e-44 hypothetical protein TcasGA2_TC001323 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 331 2.7e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 PF07962 Replication Fork Protection Component Swi3 GO:0048478//GO:0007049//GO:0006974 replication fork protection//cell cycle//cellular response to DNA damage stimulus -- -- GO:0005634 nucleus KOG1362 Choline transporter-like protein Cluster-8309.20900 BF_2 16.00 1.57 714 741829513 AJA91072.1 557 1.2e-54 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 397 1.8e-37 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.20901 BF_2 1995.63 232.63 646 270007404 EFA03852.1 251 3.3e-19 hypothetical protein TcasGA2_TC013968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20902 BF_2 87.00 4.80 1045 584482886 AHJ09940.1 611 9.6e-61 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- Q1HAY5 416 1.6e-39 Probable endopolygalacturonase B OS=Aspergillus kawachii GN=pgaB PE=3 SV=1 PF00295//PF03211 Glycosyl hydrolases family 28//Pectate lyase GO:0005982//GO:0005985//GO:0005975 starch metabolic process//sucrose metabolic process//carbohydrate metabolic process GO:0030570//GO:0004650 pectate lyase activity//polygalacturonase activity GO:0005576 extracellular region -- -- Cluster-8309.20903 BF_2 85.78 0.63 6026 91091096 XP_968472.1 1204 9.6e-129 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H221 254 5.7e-20 ATP-binding cassette sub-family G member 8 OS=Homo sapiens GN=ABCG8 PE=1 SV=1 PF00005//PF01061 ABC transporter//ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.20904 BF_2 760.89 4.20 7862 642916033 XP_008190864.1 3059 0.0e+00 PREDICTED: lisH domain and HEAT repeat-containing protein KIAA1468 homolog [Tribolium castaneum]>gi|270003733|gb|EFA00181.1| hypothetical protein TcasGA2_TC003006 [Tribolium castaneum] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q6P6Y1 798 6.2e-83 LisH domain and HEAT repeat-containing protein KIAA1468 homolog OS=Danio rerio GN=zgc:66014 PE=2 SV=1 PF02985//PF01266//PF06156 HEAT repeat//FAD dependent oxidoreductase//Protein of unknown function (DUF972) GO:0055114//GO:0006260 oxidation-reduction process//DNA replication GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- KOG3923 D-aspartate oxidase Cluster-8309.20905 BF_2 477.15 5.61 3846 270003759 EFA00207.1 1160 7.7e-124 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.58694e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.4e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.20906 BF_2 63.97 0.74 3898 270003759 EFA00207.1 1132 1.4e-120 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.64955e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.20908 BF_2 5.00 1.41 435 260810226 XP_002599904.1 136 4.8e-06 hypothetical protein BRAFLDRAFT_155447 [Branchiostoma floridae]>gi|229285188|gb|EEN55916.1| hypothetical protein BRAFLDRAFT_155447, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.20909 BF_2 372.00 6.27 2768 224458348 NP_001138958.1 1150 8.0e-123 GPI mannosyltransferase-like [Tribolium castaneum]>gi|642924177|ref|XP_008194184.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|642924179|ref|XP_008194185.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|642924181|ref|XP_008194186.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|642924183|ref|XP_008194187.1| PREDICTED: GPI mannosyltransferase-like isoform X1 [Tribolium castaneum]>gi|163716754|gb|ABY40601.1| gustatory receptor [Tribolium castaneum]>gi|270007944|gb|EFA04392.1| hypothetical protein TcasGA2_TC014690 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q290J8 680 1.0e-69 GPI mannosyltransferase 2 OS=Drosophila pseudoobscura pseudoobscura GN=GA19757 PE=3 SV=1 PF04188 Mannosyltransferase (PIG-V) GO:0006506 GPI anchor biosynthetic process GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity GO:0000136 alpha-1,6-mannosyltransferase complex KOG2647 Predicted Dolichyl-phosphate-mannose-protein mannosyltransferase Cluster-8309.20910 BF_2 2.00 0.45 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20911 BF_2 20.71 0.47 2123 642917480 XP_008191219.1 684 6.7e-69 PREDICTED: probable RNA-binding protein 18 [Tribolium castaneum]>gi|270004407|gb|EFA00855.1| hypothetical protein TcasGA2_TC003758 [Tribolium castaneum] 642917479 XM_008192997.1 130 5.18012e-59 PREDICTED: Tribolium castaneum probable RNA-binding protein 18 (LOC103312423), mRNA -- -- -- -- Q6PBM8 234 4.2e-18 Probable RNA-binding protein 18 OS=Danio rerio GN=rbm18 PE=2 SV=1 -- -- -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- -- -- Cluster-8309.20915 BF_2 24.00 1.85 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20917 BF_2 11.00 1.66 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20920 BF_2 248.55 2.07 5318 546684811 ERL94393.1 1400 1.6e-151 hypothetical protein D910_11672, partial [Dendroctonus ponderosae] 195134144 XM_002011462.1 124 2.83565e-55 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q9VY99 962 4.0e-102 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF15050//PF04952//PF04928//PF00246 SCIMP protein//Succinylglutamate desuccinylase / Aspartoacylase family//Poly(A) polymerase central domain//Zinc carboxypeptidase GO:0006508//GO:0043631//GO:0008152 proteolysis//RNA polyadenylation//metabolic process GO:0004181//GO:0008270//GO:0004652//GO:0016788 metallocarboxypeptidase activity//zinc ion binding//polynucleotide adenylyltransferase activity//hydrolase activity, acting on ester bonds GO:0097197//GO:0001772//GO:0016021 tetraspanin-enriched microdomain//immunological synapse//integral component of membrane KOG3641 Zinc carboxypeptidase Cluster-8309.20923 BF_2 216.20 6.53 1673 642936481 XP_008198455.1 1480 2.6e-161 PREDICTED: beta-1,3-glucosyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13675 B3GALTL UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13675 Q8BHT6 1156 4.0e-125 Beta-1,3-glucosyltransferase OS=Mus musculus GN=B3galtl PE=2 SV=3 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.20926 BF_2 1.00 0.53 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20927 BF_2 4.00 0.57 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20929 BF_2 10.00 1.60 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20931 BF_2 98.12 2.33 2049 546675879 ERL86984.1 1211 5.0e-130 hypothetical protein D910_04387 [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q6QHF9 483 5.4e-47 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.20937 BF_2 497.77 6.12 3687 270001355 EEZ97802.1 3734 0.0e+00 hypothetical protein TcasGA2_TC000164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 2308 2.3e-258 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 PF03810//PF02985 Importin-beta N-terminal domain//HEAT repeat GO:0006886 intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.20939 BF_2 3.00 0.40 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20940 BF_2 4.00 0.59 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20941 BF_2 313.04 6.45 2317 478252171 ENN72599.1 2666 1.1e-298 hypothetical protein YQE_10699, partial [Dendroctonus ponderosae] 683898162 XM_009102769.1 128 7.3235e-58 PREDICTED: Serinus canaria myotubularin related protein 2 (MTMR2), mRNA K18081 MTMR1_2 myotubularin-related protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18081 Q5ZIV1 2013 2.3e-224 Myotubularin-related protein 2 OS=Gallus gallus GN=MTMR2 PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.20942 BF_2 2357.00 71.10 1674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20944 BF_2 81.26 1.07 3453 642934625 XP_972040.2 2871 0.0e+00 PREDICTED: atrial natriuretic peptide-converting enzyme isoform X1 [Tribolium castaneum] 752897157 XM_011268569.1 48 3.24838e-13 PREDICTED: Camponotus floridanus atrial natriuretic peptide-converting enzyme-like (LOC105257738), mRNA -- -- -- -- Q9Z319 394 1.9e-36 Atrial natriuretic peptide-converting enzyme OS=Mus musculus GN=Corin PE=2 SV=2 PF01392//PF00057//PF00089 Fz domain//Low-density lipoprotein receptor domain class A//Trypsin GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding -- -- -- -- Cluster-8309.20951 BF_2 1.00 17.99 219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20955 BF_2 46.00 0.35 5768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01788//PF12199 PsbJ//Extracellular fibrinogen binding protein C terminal GO:0015979 photosynthesis GO:0001848 complement binding GO:0005615//GO:0009523//GO:0009539//GO:0016020 extracellular space//photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.20956 BF_2 184.64 3.12 2762 642929013 XP_008195655.1 1308 3.8e-141 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Tribolium castaneum] 759111195 XM_011357078.1 54 1.1972e-16 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K06125 COQ2 4-hydroxybenzoate polyprenyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06125 Q16QL3 1096 6.0e-118 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Aedes aegypti GN=coq2 PE=3 SV=1 PF01040//PF02366 UbiA prenyltransferase family//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0000030//GO:0004659 mannosyltransferase activity//prenyltransferase activity GO:0016021//GO:0016020//GO:0000136 integral component of membrane//membrane//alpha-1,6-mannosyltransferase complex KOG1381 Para-hydroxybenzoate-polyprenyl transferase Cluster-8309.20958 BF_2 2768.00 197.32 874 332374188 AEE62235.1 418 1.9e-38 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 352 3.6e-32 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20959 BF_2 60.63 0.85 3256 270012054 EFA08502.1 1928 5.8e-213 hypothetical protein TcasGA2_TC006154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0PV50 383 3.4e-35 Toll-like receptor 3 OS=Boselaphus tragocamelus GN=TLR3 PE=2 SV=1 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.20961 BF_2 160.07 1.30 5448 807015446 XP_012155254.1 2244 2.2e-249 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.2e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00069//PF07714//PF00628//PF00433//PF07649//PF00130 Protein kinase domain//Protein tyrosine kinase//PHD-finger//Protein kinase C terminal domain//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0055114//GO:0006468//GO:0009069//GO:0016310 intracellular signal transduction//oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0047134//GO:0004674//GO:0005524//GO:0005515 protein kinase activity//protein-disulfide reductase activity//protein serine/threonine kinase activity//ATP binding//protein binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.20963 BF_2 126.74 1.07 5250 807015446 XP_012155254.1 2240 6.2e-249 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.1e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00069//PF07649//PF00628//PF00433//PF07714//PF00130 Protein kinase domain//C1-like domain//PHD-finger//Protein kinase C terminal domain//Protein tyrosine kinase//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556//GO:0009069//GO:0006468//GO:0016310 oxidation-reduction process//intracellular signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0047134//GO:0004674//GO:0004672//GO:0005524//GO:0005515 protein-disulfide reductase activity//protein serine/threonine kinase activity//protein kinase activity//ATP binding//protein binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.20965 BF_2 107.83 1.97 2572 642925661 XP_008194659.1 1970 6.1e-218 PREDICTED: ankyrin repeat domain-containing protein 13C [Tribolium castaneum] 170028352 XM_001842008.1 81 1.09114e-31 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8N6S4 1376 1.9e-150 Ankyrin repeat domain-containing protein 13C OS=Homo sapiens GN=ANKRD13C PE=2 SV=2 PF13606//PF01213//PF00023 Ankyrin repeat//Adenylate cyclase associated (CAP) N terminal//Ankyrin repeat GO:0007010 cytoskeleton organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG0522 Ankyrin repeat protein Cluster-8309.20966 BF_2 127.72 2.37 2546 642925661 XP_008194659.1 1970 6.1e-218 PREDICTED: ankyrin repeat domain-containing protein 13C [Tribolium castaneum] 170028352 XM_001842008.1 81 1.07996e-31 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8N6S4 1376 1.9e-150 Ankyrin repeat domain-containing protein 13C OS=Homo sapiens GN=ANKRD13C PE=2 SV=2 PF00023//PF13606//PF01213 Ankyrin repeat//Ankyrin repeat//Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG0522 Ankyrin repeat protein Cluster-8309.20967 BF_2 7.00 3.21 376 -- -- -- -- -- 31580850 AB086372.1 238 7.8218e-120 Sesbania rostrata srha1 mRNA for plasma membrane H+-ATPase, complete cds -- -- -- -- Q03194 569 1.1e-57 Plasma membrane ATPase 4 OS=Nicotiana plumbaginifolia GN=PMA4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.20972 BF_2 140.25 4.05 1736 91092400 XP_969218.1 1267 1.4e-136 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 516 6.8e-51 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.20975 BF_2 1515.10 17.45 3919 642910366 XP_008200294.1 3938 0.0e+00 PREDICTED: myosin-IB [Tribolium castaneum]>gi|270014945|gb|EFA11393.1| hypothetical protein TcasGA2_TC011553 [Tribolium castaneum] 637314166 XM_008113233.1 58 1.01911e-18 PREDICTED: Anolis carolinensis myosin ID (myo1d), transcript variant X2, mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23979 3146 0.0e+00 Myosin-IB OS=Drosophila melanogaster GN=Myo61F PE=1 SV=3 PF00612//PF07475//PF00063//PF06414//PF00437//PF00485//PF06017 IQ calmodulin-binding motif//HPr Serine kinase C-terminal domain//Myosin head (motor domain)//Zeta toxin//Type II/IV secretion system protein//Phosphoribulokinase / Uridine kinase family//Unconventional myosin tail, actin- and lipid-binding GO:0016310//GO:0006109//GO:0006810//GO:0000160//GO:0008152 phosphorylation//regulation of carbohydrate metabolic process//transport//phosphorelay signal transduction system//metabolic process GO:0004672//GO:0003774//GO:0016301//GO:0005515//GO:0000155//GO:0005524 protein kinase activity//motor activity//kinase activity//protein binding//phosphorelay sensor kinase activity//ATP binding GO:0009365//GO:0016459 protein histidine kinase complex//myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.20976 BF_2 4.00 0.56 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20979 BF_2 83.56 1.02 3730 642916189 XP_008190923.1 1780 9.6e-196 PREDICTED: guanine nucleotide-binding protein-like 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36916 1157 6.9e-125 Guanine nucleotide-binding protein-like 1 OS=Mus musculus GN=Gnl1 PE=2 SV=4 PF01926//PF08477//PF03193//PF04548//PF02421//PF06858 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//AIG1 family//Ferrous iron transport protein B//Nucleolar GTP-binding protein 1 (NOG1) GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0015093//GO:0003924 GTP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.20980 BF_2 66.54 0.72 4179 642916189 XP_008190923.1 1780 1.1e-195 PREDICTED: guanine nucleotide-binding protein-like 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36916 1157 7.7e-125 Guanine nucleotide-binding protein-like 1 OS=Mus musculus GN=Gnl1 PE=2 SV=4 PF02421//PF04548//PF06858//PF01926//PF08477//PF03193 Ferrous iron transport protein B//AIG1 family//Nucleolar GTP-binding protein 1 (NOG1)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0005525//GO:0015093//GO:0003924 GTP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.20981 BF_2 133.00 2.10 2936 765117892 XP_011472470.1 622 1.4e-61 PREDICTED: LOW QUALITY PROTEIN: gastrula zinc finger protein XlCGF26.1-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- P51523 596 6.1e-60 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF07776//PF16622//PF13912//PF07975//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.20982 BF_2 4.81 0.71 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20983 BF_2 3.00 4.67 296 642926533 XP_008194909.1 174 1.3e-10 PREDICTED: uncharacterized protein LOC103313433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20984 BF_2 35.21 0.99 1769 642915071 XP_008190398.1 1315 3.8e-142 PREDICTED: protein groucho isoform X4 [Tribolium castaneum] 836708683 XM_012933491.1 309 1.34309e-158 PREDICTED: Sorex araneus transducin-like enhancer of split 3 (TLE3), transcript variant X8, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 1281 1.4e-139 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF03920 Groucho/TLE N-terminal Q-rich domain -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.20985 BF_2 455.00 10.45 2109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10233 Uncharacterized conserved protein CG6151-P -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.20986 BF_2 567.10 15.59 1809 91077536 XP_971011.1 565 3.6e-55 PREDICTED: extensin isoform X1 [Tribolium castaneum]>gi|270002152|gb|EEZ98599.1| hypothetical protein TcasGA2_TC001118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.20987 BF_2 43.16 1.11 1917 478261514 ENN80859.1 442 7.0e-41 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 331 2.1e-29 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.20988 BF_2 5.00 2.34 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.20992 BF_2 4256.47 97.57 2112 728418413 AIY68368.1 1628 2.3e-178 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 612 6.1e-62 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.20995 BF_2 8.00 4.09 366 759058480 XP_011338475.1 141 1.1e-06 PREDICTED: uncharacterized protein LOC105280011 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00292//PF03615 'Paired box' domain//GCM motif protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.20996 BF_2 202.29 3.94 2434 270005467 EFA01915.1 1081 7.1e-115 hypothetical protein TcasGA2_TC007525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KIA3 574 1.8e-57 LIM domain only protein 3 OS=Bos taurus GN=LMO3 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.20997 BF_2 18.29 0.33 2572 270005467 EFA01915.1 1081 7.5e-115 hypothetical protein TcasGA2_TC007525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q503U0 574 1.9e-57 LIM domain only protein 3 OS=Danio rerio GN=lmo3 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.20998 BF_2 21.78 0.41 2528 270005467 EFA01915.1 1085 2.5e-115 hypothetical protein TcasGA2_TC007525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YH16 574 1.9e-57 LIM domain only protein 3 OS=Xenopus laevis GN=lmo3 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.20999 BF_2 77.64 1.48 2477 270005467 EFA01915.1 1081 7.2e-115 hypothetical protein TcasGA2_TC007525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q503U0 574 1.8e-57 LIM domain only protein 3 OS=Danio rerio GN=lmo3 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.21002 BF_2 243.00 5.12 2272 -- -- -- -- -- 642933272 XM_961737.3 55 2.73241e-17 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21004 BF_2 48.44 0.76 2959 642915507 XP_008190646.1 462 5.2e-43 PREDICTED: suppressor of cytokine signaling 6 [Tribolium castaneum]>gi|270004015|gb|EFA00463.1| hypothetical protein TcasGA2_TC003320 [Tribolium castaneum] -- -- -- -- -- K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q9JLY0 390 4.7e-36 Suppressor of cytokine signaling 6 OS=Mus musculus GN=Socs6 PE=1 SV=2 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.21006 BF_2 4.00 0.59 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21014 BF_2 209.55 1.94 4814 478250173 ENN70676.1 1254 1.2e-134 hypothetical protein YQE_12621, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q88168 578 1.2e-57 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201//PF04111//PF10152//PF03153 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Autophagy protein Apg6//Predicted coiled-coil domain-containing protein (DUF2360)//Transcription factor IIA, alpha/beta subunit GO:0006914//GO:0006367//GO:0008152 autophagy//transcription initiation from RNA polymerase II promoter//metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0071203//GO:0005672 WASH complex//transcription factor TFIIA complex -- -- Cluster-8309.21017 BF_2 35.76 0.88 1984 91092400 XP_969218.1 697 1.9e-70 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 279 2.4e-23 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21018 BF_2 8.00 1.08 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF13903//PF08395 Presenilin//PMP-22/EMP/MP20/Claudin tight junction//7tm Chemosensory receptor GO:0050909 sensory perception of taste GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.21019 BF_2 111.28 0.50 9627 270015570 EFA12018.1 3062 0.0e+00 hypothetical protein TcasGA2_TC001433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86YS7 1257 4.5e-136 C2 domain-containing protein 5 OS=Homo sapiens GN=C2CD5 PE=1 SV=1 PF00168//PF08354 C2 domain//Domain of unknown function (DUF1729) GO:0006633//GO:0055114//GO:0042967 fatty acid biosynthetic process//oxidation-reduction process//acyl-carrier-protein biosynthetic process GO:0004318//GO:0005515 enoyl-[acyl-carrier-protein] reductase (NADH) activity//protein binding GO:0005835 fatty acid synthase complex KOG1031 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.21023 BF_2 61.89 1.74 1776 189237765 XP_001812950.1 493 7.9e-47 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|642924439|ref|XP_008194298.1| PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|270006791|gb|EFA03239.1| hypothetical protein TcasGA2_TC013171 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q91X85 368 1.0e-33 Feline leukemia virus subgroup C receptor-related protein 2 OS=Mus musculus GN=Flvcr2 PE=1 SV=2 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.21024 BF_2 26.56 0.59 2160 91077604 XP_976419.1 344 1.8e-29 PREDICTED: uncharacterized protein LOC662288 [Tribolium castaneum]>gi|270001560|gb|EEZ98007.1| hypothetical protein TcasGA2_TC000406 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15384//PF09302 PAXX, PAralog of XRCC4 and XLF, also called C9orf142//XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0006302//GO:0006303//GO:0006281 double-strand break repair//double-strand break repair via nonhomologous end joining//DNA repair -- -- GO:0005634 nucleus -- -- Cluster-8309.21025 BF_2 545.81 12.58 2102 91077604 XP_976419.1 506 2.9e-48 PREDICTED: uncharacterized protein LOC662288 [Tribolium castaneum]>gi|270001560|gb|EEZ98007.1| hypothetical protein TcasGA2_TC000406 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09302//PF15384 XLF-Cernunnos, XRcc4-like factor, NHEJ component//PAXX, PAralog of XRCC4 and XLF, also called C9orf142 GO:0006303//GO:0006259//GO:0006302 double-strand break repair via nonhomologous end joining//DNA metabolic process//double-strand break repair -- -- GO:0005634 nucleus -- -- Cluster-8309.21028 BF_2 84.86 0.51 7227 642922153 XP_008193036.1 2090 2.1e-231 PREDICTED: afadin isoform X1 [Tribolium castaneum] 462316425 APGK01045079.1 64 8.71492e-22 Dendroctonus ponderosae Seq01045089, whole genome shotgun sequence K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 P55196 950 1.3e-100 Afadin OS=Homo sapiens GN=MLLT4 PE=1 SV=3 PF08272//PF00788//PF11808//PF02064//PF02096//PF00498//PF05745 Topoisomerase I zinc-ribbon-like//Ras association (RalGDS/AF-6) domain//Domain of unknown function (DUF3329)//MAS20 protein import receptor//60Kd inner membrane protein//FHA domain//Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) GO:0051205//GO:0016310//GO:0006886//GO:0007165//GO:0006605//GO:0006265 protein insertion into membrane//phosphorylation//intracellular protein transport//signal transduction//protein targeting//DNA topological change GO:0005515//GO:0003677//GO:0004673//GO:0003918 protein binding//DNA binding//protein histidine kinase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0009365//GO:0016021//GO:0019867//GO:0005742//GO:0005694 protein histidine kinase complex//integral component of membrane//outer membrane//mitochondrial outer membrane translocase complex//chromosome KOG1892 Actin filament-binding protein Afadin Cluster-8309.21029 BF_2 331.30 13.48 1315 332375422 AEE62852.1 479 2.4e-45 unknown [Dendroctonus ponderosae]>gi|478254404|gb|ENN74656.1| hypothetical protein YQE_08773, partial [Dendroctonus ponderosae]>gi|546682350|gb|ERL92298.1| hypothetical protein D910_09615 [Dendroctonus ponderosae] -- -- -- -- -- K10049 CEBPG CCAAT/enhancer binding protein (C/EBP), gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10049 P26801 250 3.6e-20 CCAAT/enhancer-binding protein gamma OS=Rattus norvegicus GN=Cebpg PE=2 SV=2 PF00170//PF07716//PF06005//PF04977 bZIP transcription factor//Basic region leucine zipper//Protein of unknown function (DUF904)//Septum formation initiator GO:0000917//GO:0043093//GO:0007049//GO:0006355 barrier septum assembly//FtsZ-dependent cytokinesis//cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG3119 Basic region leucine zipper transcription factor Cluster-8309.21030 BF_2 14.70 0.57 1364 332375422 AEE62852.1 324 2.4e-27 unknown [Dendroctonus ponderosae]>gi|478254404|gb|ENN74656.1| hypothetical protein YQE_08773, partial [Dendroctonus ponderosae]>gi|546682350|gb|ERL92298.1| hypothetical protein D910_09615 [Dendroctonus ponderosae] -- -- -- -- -- K10049 CEBPG CCAAT/enhancer binding protein (C/EBP), gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10049 P26801 185 1.3e-12 CCAAT/enhancer-binding protein gamma OS=Rattus norvegicus GN=Cebpg PE=2 SV=2 PF07716 Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.21037 BF_2 27.28 1.70 957 642921130 XP_975383.3 522 1.8e-50 PREDICTED: glutaredoxin-related protein 5, mitochondrial [Tribolium castaneum] 705677805 XM_010119203.1 44 1.46921e-11 PREDICTED: Chlamydotis macqueenii glutaredoxin 5 (GLRX5), partial mRNA K07390 grxD, GLRX5 monothiol glutaredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K07390 Q86SX6 461 8.9e-45 Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens GN=GLRX5 PE=1 SV=2 PF00462 Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG0911 Glutaredoxin-related protein Cluster-8309.21038 BF_2 45.85 3.27 873 861635019 KMQ91440.1 924 4.1e-97 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] 752860622 XM_011254593.1 184 1.9956e-89 PREDICTED: Camponotus floridanus putative uncharacterized protein FLJ37770 (LOC105249263), mRNA -- -- -- -- Q7JQ07 297 8.5e-26 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.2104 BF_2 6.00 0.35 1012 334854886 AEH05998.1 690 6.4e-70 C type lectin containing domain protein [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21040 BF_2 462.00 11.50 1968 478255490 ENN75707.1 1590 5.4e-174 hypothetical protein YQE_07668, partial [Dendroctonus ponderosae]>gi|546676746|gb|ERL87702.1| hypothetical protein D910_05092 [Dendroctonus ponderosae] 827025215 LM524981.1 45 8.55226e-12 Strongyloides venezuelensis genome assembly S_venezuelensis_HH1, scaffold SVE_scaffold0000013 K06106 CTTN, EMS1 cortactin http://www.genome.jp/dbget-bin/www_bget?ko:K06106 Q60598 989 1.1e-105 Src substrate cortactin OS=Mus musculus GN=Cttn PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3655 Drebrins and related actin binding proteins Cluster-8309.21042 BF_2 69.24 1.36 2418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21043 BF_2 263.52 6.80 1909 820805536 AKG92759.1 682 1.0e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 2.91943e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 5.1e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF00010//PF01586 Helix-loop-helix DNA-binding domain//Myogenic Basic domain GO:0007517//GO:0006355 muscle organ development//regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.21045 BF_2 1421.00 71.72 1116 642935798 XP_008198179.1 565 2.2e-55 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P27591 279 1.3e-23 23 kDa integral membrane protein OS=Schistosoma japonicum PE=2 SV=1 PF16647//PF00335 Granulocyte colony-stimulating factor//Tetraspanin family GO:0007165//GO:0006955 signal transduction//immune response GO:0005125 cytokine activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG3882 Tetraspanin family integral membrane protein Cluster-8309.21047 BF_2 65.95 0.76 3916 642925611 XP_008194640.1 2652 7.7e-297 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.7e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21048 BF_2 2.00 0.45 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21050 BF_2 67.00 5.95 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21052 BF_2 49.00 0.59 3785 242023873 XP_002432355.1 2239 5.8e-249 paramyosin, long form, putative [Pediculus humanus corporis]>gi|212517778|gb|EEB19617.1| paramyosin, long form, putative [Pediculus humanus corporis] 817211444 XM_012426436.1 154 4.23508e-72 PREDICTED: Orussus abietinus paramyosin, long form-like (LOC105700530), transcript variant X2, mRNA -- -- -- -- P35415 2151 3.8e-240 Paramyosin, long form OS=Drosophila melanogaster GN=Prm PE=1 SV=1 PF06506//PF04513//PF00038//PF01576 Propionate catabolism activator//Baculovirus polyhedron envelope protein, PEP, C terminus//Intermediate filament protein//Myosin tail GO:0000160 phosphorelay signal transduction system GO:0005524//GO:0003677//GO:0005198//GO:0000156//GO:0003774 ATP binding//DNA binding//structural molecule activity//phosphorelay response regulator activity//motor activity GO:0019028//GO:0016459//GO:0019031//GO:0005882 viral capsid//myosin complex//viral envelope//intermediate filament KOG0161 Myosin class II heavy chain Cluster-8309.21053 BF_2 19.00 0.54 1754 -- -- -- -- -- 525346472 KC793944.1 102 1.56675e-43 Scylla paramamosain clone Scpa52 microsatellite sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21054 BF_2 4.00 0.44 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21056 BF_2 71.04 0.56 5623 270010959 EFA07407.1 2176 1.7e-241 protein C kinase 98E-like protein [Tribolium castaneum] 817193422 XM_012416747.1 273 4.4503e-138 PREDICTED: Orussus abietinus protein kinase C (LOC105695297), transcript variant X5, mRNA K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 P13678 1800 2.9e-199 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF07714//PF07649//PF00628//PF00069//PF00168//PF00433//PF06293 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein tyrosine kinase//C1-like domain//PHD-finger//Protein kinase domain//C2 domain//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0006468//GO:0009069//GO:0055114//GO:0035556 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0016773//GO:0047134//GO:0004672//GO:0004674 ATP binding//protein binding//phosphotransferase activity, alcohol group as acceptor//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.21057 BF_2 9.79 0.62 945 546681999 ERL91995.1 545 3.9e-53 hypothetical protein D910_09317 [Dendroctonus ponderosae] -- -- -- -- -- K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 354 2.3e-32 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF16499//PF11910 Alpha galactosidase A//Cyanobacterial and plant NDH-1 subunit O GO:0006118//GO:0055114//GO:0005975 obsolete electron transport//oxidation-reduction process//carbohydrate metabolic process GO:0004553//GO:0016655 hydrolase activity, hydrolyzing O-glycosyl compounds//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005886 plasma membrane KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.2106 BF_2 2.00 1.00 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21061 BF_2 6.00 0.53 758 795062975 XP_011873737.1 254 1.7e-19 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Vollenhovia emeryi] 807017284 XM_012305000.1 48 6.88704e-14 PREDICTED: Ceratitis capitata RING finger protein 157 (LOC101463274), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21062 BF_2 2176.00 29.67 3355 546675975 ERL87070.1 2660 7.8e-298 hypothetical protein D910_04471 [Dendroctonus ponderosae] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 O09159 1744 5.3e-193 Lysosomal alpha-mannosidase OS=Mus musculus GN=Man2b1 PE=2 SV=4 PF07748//PF01074//PF04617//PF09261//PF06298 Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain//Hox9 activation region//Alpha mannosidase, middle domain//Photosystem II protein Y (PsbY) GO:0005975//GO:0006013//GO:0015979//GO:0006351 carbohydrate metabolic process//mannose metabolic process//photosynthesis//transcription, DNA-templated GO:0008270//GO:0015923//GO:0030145//GO:0004559//GO:0004553 zinc ion binding//mannosidase activity//manganese ion binding//alpha-mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009523//GO:0016021//GO:0005634 photosystem II//integral component of membrane//nucleus KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.21063 BF_2 9.00 0.45 1132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21066 BF_2 71.00 1.62 2119 332373476 AEE61879.1 1603 1.8e-175 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11662 ACTR6, ARP6 actin-related protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11662 Q9DEE9 1021 2.3e-109 Actin-related protein 6 OS=Gallus gallus GN=ACTR6 PE=1 SV=1 PF14659 Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677 DNA binding -- -- KOG0680 Actin-related protein - Arp6p Cluster-8309.21068 BF_2 581.63 6.66 3941 642923020 XP_008200498.1 2991 0.0e+00 PREDICTED: protein ECT2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07139 1475 9.7e-162 Protein ECT2 OS=Mus musculus GN=Ect2 PE=1 SV=2 PF00621//PF02419 RhoGEF domain//PsbL protein GO:0035023//GO:0043087//GO:0015979 regulation of Rho protein signal transduction//regulation of GTPase activity//photosynthesis GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane KOG3524 Predicted guanine nucleotide exchange factor (PEBBLE) Cluster-8309.21071 BF_2 120.68 7.83 932 91085333 XP_970254.1 821 3.8e-85 PREDICTED: translational activator of cytochrome c oxidase 1 [Tribolium castaneum]>gi|270008427|gb|EFA04875.1| hypothetical protein TcasGA2_TC014933 [Tribolium castaneum] -- -- -- -- -- K18189 TACO1 translational activator of cytochrome c oxidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18189 Q9BSH4 362 2.6e-33 Translational activator of cytochrome c oxidase 1 OS=Homo sapiens GN=TACO1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2972 Uncharacterized conserved protein Cluster-8309.21073 BF_2 11.72 0.39 1531 91088569 XP_973042.1 415 7.5e-38 PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011703|gb|EFA08151.1| hypothetical protein TcasGA2_TC005769 [Tribolium castaneum] -- -- -- -- -- K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q9WVK7 265 7.6e-22 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Hadh PE=2 SV=1 PF02737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0006552//GO:0006554//GO:0055114//GO:0006568//GO:0006631//GO:0006574//GO:0006550//GO:0006633//GO:0018874 leucine catabolic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//fatty acid metabolic process//valine catabolic process//isoleucine catabolic process//fatty acid biosynthetic process//benzoate metabolic process GO:0003857//GO:0016491//GO:0070403 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//NAD+ binding -- -- KOG2304 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.21078 BF_2 23.00 1.78 827 731272986 XP_010605639.1 421 8.2e-39 PREDICTED: RAC-alpha serine/threonine-protein kinase isoform X1 [Fukomys damarensis] 440502988 JX512440.1 827 0 Homo sapiens v-akt murine thymoma viral oncogene homolog 1 (AKT1) gene, complete cds K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 P31749 418 7.5e-40 RAC-alpha serine/threonine-protein kinase OS=Homo sapiens GN=AKT1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.21084 BF_2 18.93 1.05 1038 478257487 ENN77643.1 632 3.5e-63 hypothetical protein YQE_05937, partial [Dendroctonus ponderosae]>gi|546679880|gb|ERL90268.1| hypothetical protein D910_07620 [Dendroctonus ponderosae] -- -- -- -- -- K01326 CELA1 pancreatic elastase I http://www.genome.jp/dbget-bin/www_bget?ko:K01326 Q00871 532 5.7e-53 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21088 BF_2 82.00 685.80 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21089 BF_2 51.68 0.70 3374 602166190 AHN85842.1 1650 1.0e-180 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1288 4.0e-140 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF01769//PF00001 Divalent cation transporter//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0006812 G-protein coupled receptor signaling pathway//cation transport GO:0004930//GO:0008324 G-protein coupled receptor activity//cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.21090 BF_2 232.28 2.77 3801 602166190 AHN85842.1 1751 2.3e-192 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1334 2.1e-145 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF01769//PF00001 Divalent cation transporter//7 transmembrane receptor (rhodopsin family) GO:0006812//GO:0007186 cation transport//G-protein coupled receptor signaling pathway GO:0008324//GO:0004930 cation transmembrane transporter activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.21091 BF_2 134.09 1.68 3633 642918209 XP_008191412.1 1177 7.8e-126 PREDICTED: methyltransferase-like protein 9 isoform X1 [Tribolium castaneum]>gi|270004533|gb|EFA00981.1| hypothetical protein TcasGA2_TC003894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EPL4 639 7.8e-65 Methyltransferase-like protein 9 OS=Mus musculus GN=Mettl9 PE=2 SV=1 PF05958//PF08241//PF01234//PF04218 tRNA (Uracil-5-)-methyltransferase//Methyltransferase domain//NNMT/PNMT/TEMT family//CENP-B N-terminal DNA-binding domain GO:0006396//GO:0009451//GO:0008152 RNA processing//RNA modification//metabolic process GO:0008173//GO:0003677//GO:0008168 RNA methyltransferase activity//DNA binding//methyltransferase activity -- -- KOG3987 Uncharacterized conserved protein DREV/CGI-81 Cluster-8309.21094 BF_2 51.59 0.67 3501 642926818 XP_001810169.2 2170 5.4e-241 PREDICTED: uncharacterized protein LOC100142170 isoform X1 [Tribolium castaneum] 241559510 XM_002400536.1 97 1.90009e-40 Ixodes scapularis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF17096//PF06870//PF14719 Altered inheritance of mitochondria protein 3//A49-like RNA polymerase I associated factor//Phosphotyrosine interaction domain (PTB/PID) GO:0051016//GO:0006206//GO:0006351//GO:0006144 barbed-end actin filament capping//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005730//GO:0005634//GO:0030479 nucleolus//nucleus//actin cortical patch -- -- Cluster-8309.21095 BF_2 41.00 1.37 1542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21098 BF_2 505.00 206.06 388 748995286 AJE75665.1 447 3.7e-42 putative glycosyl hydrolase [Chrysomela lapponica] 642929886 XM_970573.2 45 1.57163e-12 PREDICTED: Tribolium castaneum myrosinase 1 (LOC664577), mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 381 6.8e-36 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21100 BF_2 979.00 30.21 1643 634006736 AHZ59647.1 1641 5.5e-180 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 1164 4.7e-126 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21101 BF_2 2775.45 107.82 1364 642928984 XP_008195645.1 1449 8.4e-158 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] 748995297 KP068700.1 43 7.6062e-11 Chrysomela lapponica isolate ClGH11 putative glycosyl hydrolase mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09848 1055 1.7e-113 Lactase-phlorizin hydrolase OS=Homo sapiens GN=LCT PE=1 SV=3 PF03491//PF00232//PF00150//PF07243 Serotonin (5-HT) neurotransmitter transporter, N-terminus//Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5)//Phlebovirus glycoprotein G1 GO:0006836//GO:0008152//GO:0005975//GO:0006812 neurotransmitter transport//metabolic process//carbohydrate metabolic process//cation transport GO:0004553//GO:0005335//GO:0016798 hydrolase activity, hydrolyzing O-glycosyl compounds//serotonin:sodium symporter activity//hydrolase activity, acting on glycosyl bonds GO:0005887//GO:0019012//GO:0016021 integral component of plasma membrane//virion//integral component of membrane KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21104 BF_2 134.00 2.98 2170 642914097 XP_008201541.1 922 1.7e-96 PREDICTED: uncharacterized serine-rich protein C215.13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21105 BF_2 24.98 0.49 2421 478263645 ENN81951.1 1325 3.6e-143 hypothetical protein YQE_01662, partial [Dendroctonus ponderosae]>gi|546676684|gb|ERL87640.1| hypothetical protein D910_05031 [Dendroctonus ponderosae] -- -- -- -- -- K08870 TWF twinfilin http://www.genome.jp/dbget-bin/www_bget?ko:K08870 Q17A58 1045 4.3e-112 Twinfilin OS=Aedes aegypti GN=twf PE=3 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein Cluster-8309.21106 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21108 BF_2 9.49 0.65 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21109 BF_2 85.00 6.00 880 642917592 XP_008191271.1 334 1.1e-28 PREDICTED: UPF0488 protein CG14286 [Tribolium castaneum]>gi|270003417|gb|EEZ99864.1| hypothetical protein TcasGA2_TC002646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VE11 233 2.2e-18 UPF0488 protein CG14286 OS=Drosophila melanogaster GN=CG14286 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21112 BF_2 191.84 10.13 1079 642916794 XP_008199506.1 692 4.0e-70 PREDICTED: transmembrane protein 70 homolog, mitochondrial [Tribolium castaneum]>gi|270003058|gb|EEZ99505.1| hypothetical protein TcasGA2_TC000082 [Tribolium castaneum] -- -- -- -- -- K17966 TMEM70 transmembrane protein 70, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17966 Q95SS8 445 7.2e-43 Transmembrane protein 70 homolog, mitochondrial OS=Drosophila melanogaster GN=CG7506 PE=2 SV=1 PF03977 Na+-transporting oxaloacetate decarboxylase beta subunit GO:0006814 sodium ion transport GO:0016829 lyase activity -- -- KOG4478 Uncharacterized membrane protein Cluster-8309.21115 BF_2 724.07 19.67 1827 727098862 AIY54293.1 2157 9.0e-240 actin 1 [Colaphellus bowringi] 727098861 KJ534552.1 411 0 Colaphellus bowringi actin 1 mRNA, complete cds K18584 ACTR3, ARP3 actin-related protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18584 P32392 2008 7.0e-224 Actin-related protein 3 OS=Drosophila melanogaster GN=Arp3 PE=2 SV=3 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0678 Actin-related protein Arp2/3 complex, subunit Arp3 Cluster-8309.21119 BF_2 57.96 1.26 2205 642937652 XP_966876.3 600 3.8e-59 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62836 366 2.1e-33 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF00096//PF13465//PF06784//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Uncharacterised protein family (UPF0240)//Zinc-finger associated domain (zf-AD) GO:0032981 mitochondrial respiratory chain complex I assembly GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.21120 BF_2 5.00 0.38 838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21121 BF_2 152.72 1.82 3788 642937407 XP_008198823.1 2845 0.0e+00 PREDICTED: dynamin isoform X2 [Tribolium castaneum] -- -- -- -- -- K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 2587 1.1e-290 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF01031//PF01926//PF02212 Dynamin central region//50S ribosome-binding GTPase//Dynamin GTPase effector domain -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.21122 BF_2 2.00 19.45 234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21123 BF_2 461.77 6.96 3063 642919204 XP_008191779.1 1144 4.4e-122 PREDICTED: POU domain protein 2 [Tribolium castaneum] 820841750 XM_012483764.1 143 4.45477e-66 PREDICTED: Apis florea POU domain protein 2, isoform A-like (LOC100872881), transcript variant X3, mRNA K09364 POU2F, OTF POU domain transcription factor, class 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09364 P31368 732 1.1e-75 Protein nubbin OS=Drosophila melanogaster GN=nub PE=2 SV=1 PF03153//PF05920//PF00157//PF00046//PF00841 Transcription factor IIA, alpha/beta subunit//Homeobox KN domain//Pou domain - N-terminal to homeobox domain//Homeobox domain//Sperm histone P2 GO:0006355//GO:0006367//GO:0007283 regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter//spermatogenesis GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0000786//GO:0005667//GO:0005672 nucleus//nucleosome//transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.21124 BF_2 161.86 1.28 5593 642935437 XP_971822.3 1690 3.9e-185 PREDICTED: pancreatic triacylglycerol lipase [Tribolium castaneum] -- -- -- -- -- K11092 SNRPA1 U2 small nuclear ribonucleoprotein A' http://www.genome.jp/dbget-bin/www_bget?ko:K11092 P09661 702 5.9e-72 U2 small nuclear ribonucleoprotein A' OS=Homo sapiens GN=SNRPA1 PE=1 SV=2 PF07714//PF00975//PF00069//PF02230//PF13855 Protein tyrosine kinase//Thioesterase domain//Protein kinase domain//Phospholipase/Carboxylesterase//Leucine rich repeat GO:0009058//GO:0006468 biosynthetic process//protein phosphorylation GO:0004672//GO:0005515//GO:0016787//GO:0005524//GO:0016788 protein kinase activity//protein binding//hydrolase activity//ATP binding//hydrolase activity, acting on ester bonds -- -- KOG1644 U2-associated snRNP A' protein Cluster-8309.21127 BF_2 4078.95 381.01 735 91078008 XP_969762.1 273 1.1e-21 PREDICTED: fatty acid-binding protein, liver [Tribolium castaneum]>gi|270002862|gb|EEZ99309.1| cellular FABP-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21128 BF_2 15.00 0.73 1152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21130 BF_2 4454.00 1566.77 405 94468538 ABF18118.1 180 3.5e-11 TIL domain-containing cysteine-rich salivary secreted peptide [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21131 BF_2 79.56 1.90 2042 91090139 XP_971650.1 1351 2.9e-146 PREDICTED: WEB family protein At3g02930, chloroplastic [Tribolium castaneum]>gi|270013743|gb|EFA10191.1| hypothetical protein TcasGA2_TC012383 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050//PF10473//PF12467//PF13851//PF05929//PF06156//PF07851//PF04111 Flagellar FliJ protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Cucumber mosaic virus 1a protein family//Growth-arrest specific micro-tubule binding//Phage capsid scaffolding protein (GPO) serine peptidase//Protein of unknown function (DUF972)//TMPIT-like protein//Autophagy protein Apg6 GO:0019069//GO:0048870//GO:0071973//GO:0006935//GO:0006260//GO:0006914 viral capsid assembly//cell motility//bacterial-type flagellum-dependent cell motility//chemotaxis//DNA replication//autophagy GO:0016817//GO:0003774//GO:0042803//GO:0008168//GO:0008134//GO:0045502 hydrolase activity, acting on acid anhydrides//motor activity//protein homodimerization activity//methyltransferase activity//transcription factor binding//dynein binding GO:0016020//GO:0005667//GO:0030286//GO:0009288//GO:0031514//GO:0016021 membrane//transcription factor complex//dynein complex//bacterial-type flagellum//motile cilium//integral component of membrane -- -- Cluster-8309.21133 BF_2 48.55 1.19 1993 270008834 EFA05282.1 970 4.3e-102 hypothetical protein TcasGA2_TC015439 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02599 388 5.4e-36 Calmodulin OS=Dictyostelium discoideum GN=calA PE=1 SV=3 PF00036//PF10591//PF13833//PF13405//PF13499//PF13202//PF12763 EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.21135 BF_2 367.45 19.29 1084 478263679 ENN81985.1 1350 2.0e-146 hypothetical protein YQE_01696, partial [Dendroctonus ponderosae]>gi|546676718|gb|ERL87674.1| hypothetical protein D910_05064 [Dendroctonus ponderosae] 557016035 XM_006008402.1 52 5.96892e-16 PREDICTED: Latimeria chalumnae unconventional myosin-Ig-like (LOC102346417), partial mRNA K10358 MYO6 myosin VI http://www.genome.jp/dbget-bin/www_bget?ko:K10358 Q01989 1088 2.0e-117 Myosin heavy chain 95F OS=Drosophila melanogaster GN=jar PE=2 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0163 Myosin class VI heavy chain Cluster-8309.21139 BF_2 25.78 0.48 2546 642918750 XP_008191568.1 609 4.0e-60 PREDICTED: palmitoyltransferase ZDHHC7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NYG2 282 1.4e-23 Palmitoyltransferase ZDHHC3 OS=Homo sapiens GN=ZDHHC3 PE=1 SV=2 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.21141 BF_2 1349.00 66.17 1140 357630586 EHJ78604.1 235 4.2e-17 intestinal mucin [Danaus plexippus] -- -- -- -- -- -- -- -- -- Q9W5U2 126 7.5e-06 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.21142 BF_2 632.99 12.61 2387 91086483 XP_970457.1 1660 5.0e-182 PREDICTED: RING finger protein nhl-1 [Tribolium castaneum]>gi|270009807|gb|EFA06255.1| hypothetical protein TcasGA2_TC009114 [Tribolium castaneum] -- -- -- -- -- K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 238 1.6e-18 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF13639//PF01436//PF00097//PF04281//PF14634 Ring finger domain//NHL repeat//Zinc finger, C3HC4 type (RING finger)//Mitochondrial import receptor subunit Tom22//zinc-RING finger domain GO:0006886 intracellular protein transport GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding GO:0005741 mitochondrial outer membrane KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.21144 BF_2 242.45 4.76 2417 478260221 ENN79984.1 223 2.2e-15 hypothetical protein YQE_03578, partial [Dendroctonus ponderosae]>gi|546675215|gb|ERL86451.1| hypothetical protein D910_03858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21146 BF_2 17.94 0.61 1526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2115 BF_2 18.00 0.45 1972 642910848 XP_008193434.1 253 5.9e-19 PREDICTED: uncharacterized protein LOC100142427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21151 BF_2 47.00 2.06 1241 546673461 ERL85059.1 703 2.4e-71 hypothetical protein D910_02482 [Dendroctonus ponderosae] -- -- -- -- -- K11666 INO80B, ZNHIT4, PAPA1 INO80 complex subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K11666 Q99PT3 194 1.1e-13 INO80 complex subunit B OS=Mus musculus GN=Ino80b PE=1 SV=2 PF04795 PAPA-1-like conserved region -- -- -- -- GO:0031011 Ino80 complex -- -- Cluster-8309.21154 BF_2 114.89 1.08 4719 642913900 XP_008201205.1 4652 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 P53995 2470 4.9e-277 Anaphase-promoting complex subunit 1 OS=Mus musculus GN=Anapc1 PE=2 SV=2 PF07475 HPr Serine kinase C-terminal domain GO:0000160//GO:0006109//GO:0016310 phosphorelay signal transduction system//regulation of carbohydrate metabolic process//phosphorylation GO:0000155//GO:0005524//GO:0004672 phosphorelay sensor kinase activity//ATP binding//protein kinase activity GO:0009365 protein histidine kinase complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.21155 BF_2 1822.92 35.70 2423 282721150 NP_001164240.1 675 8.4e-68 serine protease P38 precursor [Tribolium castaneum]>gi|270004827|gb|EFA01275.1| serine protease P38 [Tribolium castaneum] -- -- -- -- -- K01329 CMA1 chymase http://www.genome.jp/dbget-bin/www_bget?ko:K01329 P00771 454 1.5e-43 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.21156 BF_2 86.86 0.44 8528 642916934 XP_008199560.1 3515 0.0e+00 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] 642916933 XM_008201338.1 374 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase HSL1 (LOC660568), mRNA K08853 AAK AP2-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08853 F1MH24 1145 3.9e-123 AP2-associated protein kinase 1 OS=Bos taurus GN=AAK1 PE=1 SV=2 PF00069//PF07714//PF07578 Protein kinase domain//Protein tyrosine kinase//Lipid A Biosynthesis N-terminal domain GO:0006468//GO:0009245 protein phosphorylation//lipid A biosynthetic process GO:0008915//GO:0004672//GO:0005524 lipid-A-disaccharide synthase activity//protein kinase activity//ATP binding -- -- KOG1989 ARK protein kinase family Cluster-8309.21159 BF_2 42.94 0.79 2550 91088303 XP_969204.1 1591 5.4e-174 PREDICTED: limbic system-associated membrane protein [Tribolium castaneum]>gi|270012163|gb|EFA08611.1| hypothetical protein TcasGA2_TC006274 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 318 9.1e-28 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF00041//PF13895//PF04006//PF05790 Fibronectin type III domain//Immunoglobulin domain//Mpp10 protein//Immunoglobulin C2-set domain GO:0006364//GO:0007155 rRNA processing//cell adhesion GO:0005515 protein binding GO:0034457//GO:0005634//GO:0005732//GO:0016021 Mpp10 complex//nucleus//small nucleolar ribonucleoprotein complex//integral component of membrane -- -- Cluster-8309.21160 BF_2 13.09 0.34 1918 270002713 EEZ99160.1 224 1.3e-15 hypothetical protein TcasGA2_TC016159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04561 RNA polymerase Rpb2, domain 2 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.21161 BF_2 4.00 14.09 264 817060055 XP_012251562.1 266 2.4e-21 PREDICTED: alpha-amylase-like isoform X1 [Athalia rosae] -- -- -- -- -- K01176 E3.2.1.1, amyA, malS alpha-amylase http://www.genome.jp/dbget-bin/www_bget?ko:K01176 P09107 263 2.2e-22 Alpha-amylase (Fragment) OS=Tribolium castaneum PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2212 Alpha-amylase Cluster-8309.21162 BF_2 148.00 6.17 1291 4557953 1TMQ 1360 1.7e-147 Chain A, Structure Of Tenebrio Molitor Larval Alpha-Amylase In Complex With Ragi Bifunctional Inhibitor>gi|7766814|pdb|1CLV|A Chain A, Yellow Meal Worm Alpha-Amylase In Complex With The Amaranth Alpha-Amylase Inhibitor>gi|157831531|pdb|1JAE|A Chain A, Structure Of Tenebrio Molitor Larval Alpha-Amylase -- -- -- -- -- K01176 E3.2.1.1, amyA, malS alpha-amylase http://www.genome.jp/dbget-bin/www_bget?ko:K01176 P56634 1360 6.9e-149 Alpha-amylase OS=Tenebrio molitor PE=1 SV=1 PF02806//PF00128//PF07745 Alpha amylase, C-terminal all-beta domain//Alpha amylase, catalytic domain//Glycosyl hydrolase family 53 GO:0005975//GO:0008152 carbohydrate metabolic process//metabolic process GO:0015926//GO:0016798//GO:0003824//GO:0043169 glucosidase activity//hydrolase activity, acting on glycosyl bonds//catalytic activity//cation binding -- -- KOG2212 Alpha-amylase Cluster-8309.21164 BF_2 22.73 1.28 1029 478252396 ENN72822.1 955 1.2e-100 hypothetical protein YQE_10625, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R599 496 8.4e-49 Translin-associated protein X OS=Macaca fascicularis GN=TSNAX PE=2 SV=1 PF01997 Translin family -- -- GO:0043565 sequence-specific DNA binding -- -- KOG3066 Translin-associated protein X Cluster-8309.21165 BF_2 94.45 1.80 2480 642915433 XP_008190613.1 571 9.9e-56 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445//PF13673//PF13302//PF00583//PF13508//PF12142 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Polyphenol oxidase middle domain GO:0055114//GO:0006570//GO:0042967//GO:0006118 oxidation-reduction process//tyrosine metabolic process//acyl-carrier-protein biosynthetic process//obsolete electron transport GO:0008080//GO:0004097//GO:0016747 N-acetyltransferase activity//catechol oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.21167 BF_2 3.00 0.39 610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.21170 BF_2 313.12 4.45 3230 546684811 ERL94393.1 1865 1.2e-205 hypothetical protein D910_11672, partial [Dendroctonus ponderosae] 195134144 XM_002011462.1 52 1.81455e-15 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q9VY99 1021 3.5e-109 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF00246//PF04928//PF04952 Zinc carboxypeptidase//Poly(A) polymerase central domain//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0043631//GO:0008152 proteolysis//RNA polyadenylation//metabolic process GO:0016788//GO:0008270//GO:0004652//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//polynucleotide adenylyltransferase activity//metallocarboxypeptidase activity -- -- KOG3641 Zinc carboxypeptidase Cluster-8309.21173 BF_2 76.03 1.09 3199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21176 BF_2 8.00 23.07 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21177 BF_2 2.00 3.12 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21179 BF_2 70.72 0.81 3925 642914904 XP_008190437.1 1293 3.0e-139 PREDICTED: aldehyde dehydrogenase 5, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T1L0 282 2.1e-23 Aldehyde dehydrogenase family 16 member A1 OS=Rattus norvegicus GN=Aldh16a1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.2118 BF_2 2.00 0.45 473 817063364 XP_012253379.1 210 1.4e-14 PREDICTED: collagen alpha-1(XI) chain-like [Athalia rosae] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21181 BF_2 155.64 2.51 2879 332376294 AEE63287.1 1800 3.5e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 9.72065e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 6.2e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005991//GO:0005985//GO:0005982 trehalose metabolic process//sucrose metabolic process//starch metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.21182 BF_2 86.12 1.92 2164 728418332 AIY68365.1 1305 6.7e-141 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 459 3.5e-44 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF08563 alpha/beta hydrolase fold//P53 transactivation motif GO:0008152 metabolic process GO:0005515//GO:0016787 protein binding//hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.21184 BF_2 250.53 5.76 2107 478253814 ENN74106.1 498 2.5e-47 hypothetical protein YQE_09079, partial [Dendroctonus ponderosae]>gi|546684620|gb|ERL94237.1| hypothetical protein D910_11518 [Dendroctonus ponderosae] -- -- -- -- -- K03122 TFIIA1, GTF2A1, TOA1 transcription initiation factor TFIIA large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03122 P52654 272 1.6e-22 Transcription initiation factor IIA subunit 1 OS=Drosophila melanogaster GN=TfIIA-L PE=1 SV=2 PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain Cluster-8309.21185 BF_2 9.00 0.55 975 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21186 BF_2 75.66 0.71 4755 91081535 XP_974904.1 2249 5.1e-250 PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921048|ref|XP_008192670.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921050|ref|XP_008192671.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|270006169|gb|EFA02617.1| hypothetical protein TcasGA2_TC008337 [Tribolium castaneum] 642921051 XM_969811.2 41 3.49261e-09 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase Suv4-20 (LOC663776), transcript variant X3, mRNA K11429 SUV420H histone-lysine N-methyltransferase SUV420H http://www.genome.jp/dbget-bin/www_bget?ko:K11429 Q9W5E0 1092 3.0e-117 Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster GN=Hmt4-20 PE=1 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2589 Histone tail methylase Cluster-8309.21187 BF_2 219.71 6.21 1768 308191588 A2V735.1 1106 6.5e-118 RecName: Full=Tropomyosin; AltName: Full=Tropomyosin, slow-tonic isoform; Short=Tm-Chio-tonic [Chionoecetes opilio]>gi|125995167|dbj|BAF47267.1| tropomyosin slow-tonic isoform [Chionoecetes opilio] 125995170 AB270636.1 860 0 Erimacrus isenbeckii Tm-Erii-tonic mRNA for tropomyosin slow-tonic isoform, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 O44119 1115 2.4e-120 Tropomyosin OS=Homarus americanus GN=TM1 PE=1 SV=1 PF08702//PF00769//PF05557//PF07926//PF10473//PF05739//PF06160//PF06109//PF16716//PF06008//PF14073//PF07167//PF00435//PF04111//PF06009 Fibrinogen alpha/beta chain family//Ezrin/radixin/moesin family//Mitotic checkpoint protein//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Septation ring formation regulator, EzrA//Haemolysin E (HlyE)//Bone marrow stromal antigen 2//Laminin Domain I//Centrosome localisation domain of Cep57//Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus//Spectrin repeat//Autophagy protein Apg6//Laminin Domain II GO:0051607//GO:0007094//GO:0007155//GO:0030155//GO:0009405//GO:0007165//GO:0044179//GO:0030334//GO:0051258//GO:0006914//GO:0042619//GO:0000921//GO:0030168//GO:0006606//GO:0045995 defense response to virus//mitotic spindle assembly checkpoint//cell adhesion//regulation of cell adhesion//pathogenesis//signal transduction//hemolysis in other organism//regulation of cell migration//protein polymerization//autophagy//poly-hydroxybutyrate biosynthetic process//septin ring assembly//platelet activation//protein import into nucleus//regulation of embryonic development GO:0042802//GO:0005515//GO:0043015//GO:0042803//GO:0008092//GO:0030674//GO:0008134//GO:0045502//GO:0005102 identical protein binding//protein binding//gamma-tubulin binding//protein homodimerization activity//cytoskeletal protein binding//protein binding, bridging//transcription factor binding//dynein binding//receptor binding GO:0016021//GO:0005940//GO:0005737//GO:0030286//GO:0005667//GO:0019898//GO:0045298//GO:0005577 integral component of membrane//septin ring//cytoplasm//dynein complex//transcription factor complex//extrinsic component of membrane//tubulin complex//fibrinogen complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.21189 BF_2 40.31 1.26 1624 642925505 XP_008194578.1 806 3.6e-83 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 390 2.6e-36 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF06687//PF04999 SUR7/PalI family//Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.21190 BF_2 139.31 0.92 6645 642918326 XP_008199092.1 2616 2.0e-292 PREDICTED: protein Shroom [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 1.3e-33 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 PF07353 Uroplakin II GO:0061024 membrane organization -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.21195 BF_2 42.96 0.65 3071 332376975 AEE63627.1 1501 1.8e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 5.77784e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 2.5e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF04545//PF00382//PF01857//PF02984 Sigma-70, region 4//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Cyclin, C-terminal domain GO:0051726//GO:0006352//GO:0006355 regulation of cell cycle//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0017025//GO:0016987 DNA binding//transcription factor activity, sequence-specific DNA binding//TBP-class protein binding//sigma factor activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.21196 BF_2 53.86 1.26 2080 546677470 ERL88302.1 1949 1.4e-215 hypothetical protein D910_05689 [Dendroctonus ponderosae] 642912507 XM_966689.2 445 0 PREDICTED: Tribolium castaneum cyclin dependent kinase 8 (LOC660461), mRNA K02208 CDK8_11 cyclin-dependent kinase 8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K02208 Q17IE8 1791 1.2e-198 Cyclin-dependent kinase 8 OS=Aedes aegypti GN=Cdk8 PE=3 SV=2 PF02932//PF02724//PF07714//PF06213//PF04973//PF00069 Neurotransmitter-gated ion-channel transmembrane region//CDC45-like protein//Protein tyrosine kinase//Cobalamin biosynthesis protein CobT//Nicotinamide mononucleotide transporter//Protein kinase domain GO:0009236//GO:0006811//GO:0034258//GO:0006270//GO:0006468 cobalamin biosynthetic process//ion transport//nicotinamide riboside transport//DNA replication initiation//protein phosphorylation GO:0004672//GO:0034257//GO:0005524 protein kinase activity//nicotinamide riboside transmembrane transporter activity//ATP binding GO:0016020 membrane KOG0666 Cyclin C-dependent kinase CDK8 Cluster-8309.21198 BF_2 2.00 1.33 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21199 BF_2 86.72 0.90 4321 478252657 ENN73061.1 1798 9.1e-198 hypothetical protein YQE_10331, partial [Dendroctonus ponderosae] -- -- -- -- -- K10770 ALKBH8 alkylated DNA repair protein alkB homolog 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10770 Q07G10 1262 5.3e-137 Alkylated DNA repair protein alkB homolog 8 OS=Xenopus tropicalis GN=alkbh8 PE=2 SV=2 PF01209//PF04083//PF01738//PF08241//PF08168 ubiE/COQ5 methyltransferase family//Partial alpha/beta-hydrolase lipase region//Dienelactone hydrolase family//Methyltransferase domain//NUC205 domain GO:0006629//GO:0008152 lipid metabolic process//metabolic process GO:0016787//GO:0008168 hydrolase activity//methyltransferase activity GO:0005634 nucleus -- -- Cluster-8309.21200 BF_2 390.17 6.60 2762 91080721 XP_975378.1 1530 6.9e-167 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005867|gb|EFA02315.1| hypothetical protein TcasGA2_TC007981 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 Q5VXJ0 718 4.1e-74 Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2 PF01738//PF08168//PF04083 Dienelactone hydrolase family//NUC205 domain//Partial alpha/beta-hydrolase lipase region GO:0016042//GO:0006629 lipid catabolic process//lipid metabolic process GO:0016788//GO:0016787 hydrolase activity, acting on ester bonds//hydrolase activity GO:0005634 nucleus KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.21201 BF_2 66.00 2.73 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21202 BF_2 360.28 18.29 1111 741829513 AJA91072.1 945 1.9e-99 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 638 3.1e-65 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0055114//GO:0051249//GO:0006955 oxidation-reduction process//regulation of lymphocyte activation//immune response GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.21203 BF_2 90.31 2.78 1647 642925155 XP_008194449.1 1294 9.6e-140 PREDICTED: zinc finger protein 431-like [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 492 3.9e-48 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF16622//PF07776//PF13912//PF05443//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//ROS/MUCR transcriptional regulator protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.21204 BF_2 49.89 1.88 1396 91079146 XP_966535.1 641 4.3e-64 PREDICTED: ankyrin repeat domain-containing protein 49 [Tribolium castaneum]>gi|270004231|gb|EFA00679.1| hypothetical protein TcasGA2_TC003556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VE42 396 4.5e-37 Ankyrin repeat domain-containing protein 49 OS=Mus musculus GN=Ankrd49 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21210 BF_2 38.69 0.72 2534 194578879 NP_001034528.2 1164 1.7e-124 distal-less [Tribolium castaneum]>gi|270011030|gb|EFA07478.1| distal-less [Tribolium castaneum] 194578878 NM_001039439.2 508 0 Tribolium castaneum distal-less (Dll), mRNA K18488 DLX2 homeobox protein DLX2 http://www.genome.jp/dbget-bin/www_bget?ko:K18488 P20009 476 4.3e-46 Homeotic protein distal-less OS=Drosophila melanogaster GN=Dll PE=2 SV=3 PF01787//PF05920//PF00046 Ilarvirus coat protein//Homeobox KN domain//Homeobox domain GO:0006355//GO:0006413 regulation of transcription, DNA-templated//translational initiation GO:0043565//GO:0003723//GO:0003677 sequence-specific DNA binding//RNA binding//DNA binding GO:0019012 virion KOG0850 Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains Cluster-8309.21211 BF_2 198.31 3.72 2516 194578879 NP_001034528.2 1100 4.6e-117 distal-less [Tribolium castaneum]>gi|270011030|gb|EFA07478.1| distal-less [Tribolium castaneum] 194578878 NM_001039439.2 544 0 Tribolium castaneum distal-less (Dll), mRNA K18488 DLX2 homeobox protein DLX2 http://www.genome.jp/dbget-bin/www_bget?ko:K18488 P20009 476 4.3e-46 Homeotic protein distal-less OS=Drosophila melanogaster GN=Dll PE=2 SV=3 PF01787//PF05920//PF00046 Ilarvirus coat protein//Homeobox KN domain//Homeobox domain GO:0006355//GO:0006413 regulation of transcription, DNA-templated//translational initiation GO:0003723//GO:0003677 RNA binding//DNA binding GO:0019012 virion KOG0850 Transcription factor DLX and related proteins with LIM Zn-binding and HOX domains Cluster-8309.21213 BF_2 3.00 3.72 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21216 BF_2 3.00 2.78 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21217 BF_2 13.00 1.04 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21218 BF_2 1426.69 32.94 2099 642933315 XP_008197365.1 2015 3.0e-223 PREDICTED: beta-glucuronidase-like [Tribolium castaneum] -- -- -- -- -- K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P12265 1295 3.8e-141 Beta-glucuronidase OS=Mus musculus GN=Gusb PE=2 SV=2 PF02836//PF00150//PF02837//PF00703 Glycosyl hydrolases family 2, TIM barrel domain//Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolases family 2, sugar binding domain//Glycosyl hydrolases family 2 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.21220 BF_2 18.97 0.35 2531 642932825 XP_008197001.1 1339 8.9e-145 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P20735 684 3.3e-70 Gamma-glutamyltranspeptidase 1 OS=Sus scrofa GN=GGT1 PE=2 SV=1 PF01019//PF00957 Gamma-glutamyltranspeptidase//Synaptobrevin GO:0006749//GO:0006693//GO:0006691//GO:0019530//GO:0016192 glutathione metabolic process//prostaglandin metabolic process//leukotriene metabolic process//taurine metabolic process//vesicle-mediated transport GO:0003840 gamma-glutamyltransferase activity GO:0016021 integral component of membrane KOG2410 Gamma-glutamyltransferase Cluster-8309.21221 BF_2 20.00 0.59 1695 268588965 ACZ06791.1 817 2.0e-84 eukaryotic translation initiation factor 5A [Scylla paramamosain] 268588964 FJ825623.1 926 0 Scylla paramamosain eukaryotic translation initiation factor 5A mRNA, complete cds K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 P62925 595 4.6e-60 Eukaryotic translation initiation factor 5A OS=Spodoptera frugiperda GN=eIF-5A PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0045901//GO:0045905//GO:0006448//GO:0006452 positive regulation of translational elongation//positive regulation of translational termination//regulation of translational elongation//translational frameshifting GO:0003746//GO:0003723//GO:0043022 translation elongation factor activity//RNA binding//ribosome binding GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-8309.21225 BF_2 2.00 1.76 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21226 BF_2 232.10 4.66 2372 189233695 XP_001812208.1 494 8.0e-47 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 369 1.0e-33 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367//PF08777//PF00010 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif//Helix-loop-helix DNA-binding domain -- -- GO:0003676//GO:0003723//GO:0046983 nucleic acid binding//RNA binding//protein dimerization activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.21227 BF_2 18.00 0.51 1767 478257106 ENN77269.1 374 4.9e-33 hypothetical protein YQE_06097, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21230 BF_2 3.00 2.23 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09230 DNA fragmentation factor 40 kDa GO:0006309 apoptotic DNA fragmentation GO:0016787 hydrolase activity GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.21231 BF_2 10.00 0.72 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21233 BF_2 835.13 143.81 530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.21237 BF_2 2.00 0.35 525 642935142 XP_008197905.1 284 4.0e-23 PREDICTED: putative acyl-activating enzyme 19 [Tribolium castaneum]>gi|270013381|gb|EFA09829.1| hypothetical protein TcasGA2_TC011976 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.21238 BF_2 11.39 0.37 1567 805815980 XP_012148641.1 218 5.4e-15 PREDICTED: uncharacterized protein LOC105663574 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21239 BF_2 182.41 1.49 5420 642937954 XP_008199143.1 2922 0.0e+00 PREDICTED: isoleucine--tRNA ligase, mitochondrial [Tribolium castaneum] 571578376 XM_006572314.1 45 2.38132e-11 PREDICTED: Apis mellifera isoleucyl-tRNA synthetase, mitochondrial-like (LOC726483), partial mRNA K01870 IARS, ileS isoleucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01870 Q4R646 1886 2.9e-209 Isoleucine--tRNA ligase, mitochondrial (Fragment) OS=Macaca fascicularis GN=IARS2 PE=2 SV=2 PF00133//PF09334//PF08264//PF10473//PF05746 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Anticodon-binding domain of tRNA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//DALR anticodon binding domain GO:0006560//GO:0006525//GO:0006418//GO:0006420 proline metabolic process//arginine metabolic process//tRNA aminoacylation for protein translation//arginyl-tRNA aminoacylation GO:0045502//GO:0008134//GO:0004814//GO:0005524//GO:0004812//GO:0000166//GO:0042803 dynein binding//transcription factor binding//arginine-tRNA ligase activity//ATP binding//aminoacyl-tRNA ligase activity//nucleotide binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex KOG0433 Isoleucyl-tRNA synthetase Cluster-8309.21242 BF_2 57.00 2.14 1403 664818432 AIF73508.1 1407 6.4e-153 UV2 opsin, partial [Neogonodactylus oerstedii] 761599447 LC009300.1 43 7.82941e-11 Indolestes peregrinus RhSWa1 mRNA for opsin, short-wavelength sensitive type, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 O61303 1088 2.6e-117 Opsin, ultraviolet-sensitive OS=Apis mellifera GN=UVOP PE=1 SV=1 PF00001//PF02679 7 transmembrane receptor (rhodopsin family)//(2R)-phospho-3-sulfolactate synthase (ComA) GO:0019295//GO:0007186 coenzyme M biosynthetic process//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.21243 BF_2 24.00 1.60 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21244 BF_2 3.00 11.57 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21245 BF_2 67.00 0.59 5037 189237219 XP_001810222.1 4173 0.0e+00 PREDICTED: adenylate cyclase type 3 [Tribolium castaneum] 641655812 XM_001947691.3 187 2.55508e-90 PREDICTED: Acyrthosiphon pisum adenylate cyclase type 3 (LOC100163190), partial mRNA K08043 ADCY3 adenylate cyclase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08043 O60266 1830 8.5e-203 Adenylate cyclase type 3 OS=Homo sapiens GN=ADCY3 PE=2 SV=3 PF00211//PF04437//PF07701 Adenylate and Guanylate cyclase catalytic domain//RINT-1 / TIP-1 family//Heme NO binding associated GO:0006182//GO:0046039//GO:0006144//GO:0048193//GO:0035556//GO:0009190 cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process//Golgi vesicle transport//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0004383//GO:0016849 guanylate cyclase activity//phosphorus-oxygen lyase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.21250 BF_2 5.05 0.57 660 524901033 XP_005106931.1 165 3.2e-09 PREDICTED: ras-related protein Rab-1A [Aplysia californica] -- -- -- -- -- -- -- -- -- Q05974 161 3.8e-10 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF08477//PF00071 Ras of Complex, Roc, domain of DAPkinase//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.21251 BF_2 10.00 2.56 450 350578988 XP_003480495.1 349 9.9e-31 PREDICTED: dual specificity mitogen-activated protein kinase kinase 1-like [Sus scrofa] 194688128 NG_008305.1 447 0 Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), RefSeqGene (LRG_725) on chromosome 15 K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q90321 267 1.3e-22 Dual specificity mitogen-activated protein kinase kinase 2 OS=Cyprinus carpio GN=map2k2 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-8309.21254 BF_2 4.96 1.03 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21255 BF_2 289.00 15.17 1084 546683574 ERL93372.1 621 6.9e-62 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- K08666 KLK4, PRSS17 kallikrein 4 (prostase, enamel matrix, prostate) http://www.genome.jp/dbget-bin/www_bget?ko:K08666 Q00871 503 1.4e-49 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21256 BF_2 175.04 1.55 5009 642940386 XP_008200540.1 2415 3.0e-269 PREDICTED: chitin deacetylase 5 isoform X1 [Tribolium castaneum] 827560342 XM_012695639.1 311 2.97677e-159 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0005975//GO:0006807//GO:0006030 carbohydrate metabolic process//nitrogen compound metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.21257 BF_2 287.00 40.71 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21264 BF_2 23.97 0.49 2331 91080239 XP_972955.1 1621 1.6e-177 PREDICTED: TNF receptor-associated factor 6 [Tribolium castaneum]>gi|270006403|gb|EFA02851.1| TNF-receptor-associated factor 2 [Tribolium castaneum] -- -- -- -- -- K03175 TRAF6 TNF receptor-associated factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03175 A7XUJ6 378 9.2e-35 TNF receptor-associated factor 6 OS=Sus scrofa GN=TRAF6 PE=2 SV=1 PF17123//PF12678//PF14634//PF04564//PF00097//PF11789//PF02176//PF12861//PF13639//PF16685 RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//U-box domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//TRAF-type zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//zinc RING finger of MSL2 GO:0016567 protein ubiquitination GO:0008270//GO:0061630//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.21265 BF_2 11.81 0.31 1891 642910205 XP_008198403.1 238 3.1e-17 PREDICTED: NF-kappa-B-repressing factor-like [Tribolium castaneum]>gi|270014634|gb|EFA11082.1| hypothetical protein TcasGA2_TC004678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01424//PF01585 R3H domain//G-patch domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.21268 BF_2 29.80 1.29 1252 270016479 EFA12925.1 283 1.2e-22 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82596 175 1.7e-11 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21271 BF_2 18.00 0.53 1714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21277 BF_2 131.85 6.14 1185 91086847 XP_974260.1 1014 2.0e-107 PREDICTED: BSD domain-containing protein 1-B [Tribolium castaneum]>gi|270010460|gb|EFA06908.1| hypothetical protein TcasGA2_TC009857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BJ78 333 7.7e-30 BSD domain-containing protein 1 OS=Xenopus tropicalis GN=bsdc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2690 Uncharacterized conserved protein, contains BSD domain Cluster-8309.21279 BF_2 82.24 1.96 2041 642916474 XP_008191059.1 1647 1.4e-180 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270004236|gb|EFA00684.1| hypothetical protein TcasGA2_TC003561 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 829 4.1e-87 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 PF06423//PF04923 GWT1//Ninjurin GO:0042246//GO:0007155//GO:0006506 tissue regeneration//cell adhesion//GPI anchor biosynthetic process GO:0016746 transferase activity, transferring acyl groups GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG4683 Uncharacterized conserved protein Cluster-8309.21280 BF_2 93.76 2.53 1839 642916474 XP_008191059.1 1647 1.3e-180 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270004236|gb|EFA00684.1| hypothetical protein TcasGA2_TC003561 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 829 3.7e-87 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 PF04923//PF06423 Ninjurin//GWT1 GO:0006506//GO:0007155//GO:0042246 GPI anchor biosynthetic process//cell adhesion//tissue regeneration GO:0016746 transferase activity, transferring acyl groups GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG4683 Uncharacterized conserved protein Cluster-8309.21281 BF_2 380.00 282.27 337 170041612 XP_001848550.1 138 2.2e-06 conserved hypothetical protein [Culex quinquefasciatus]>gi|167865188|gb|EDS28571.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07936 Potassium-channel blocking toxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0042151 nematocyst -- -- Cluster-8309.21283 BF_2 982.00 15.73 2899 478254059 ENN74351.1 1545 1.3e-168 hypothetical protein YQE_09321, partial [Dendroctonus ponderosae]>gi|546672810|gb|ERL84566.1| hypothetical protein D910_01995 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01141 Gag polyprotein, inner coat protein p12 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.21284 BF_2 289.96 7.09 1997 642917151 XP_008191139.1 2389 1.2e-266 PREDICTED: F-box-like/WD repeat-containing protein TBL1XR1 [Tribolium castaneum]>gi|270004371|gb|EFA00819.1| hypothetical protein TcasGA2_TC003706 [Tribolium castaneum] 442624961 NM_057981.4 286 9.27654e-146 Drosophila melanogaster ebi (ebi), mRNA K04508 TBL1 transducin (beta)-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04508 Q8BHJ5 2046 3.0e-228 F-box-like/WD repeat-containing protein TBL1XR1 OS=Mus musculus GN=Tbl1xr1 PE=1 SV=1 PF01588//PF00400//PF00457//PF08513//PF04053 Putative tRNA binding domain//WD domain, G-beta repeat//Glycosyl hydrolases family 11//LisH//Coatomer WD associated region GO:0016192//GO:0006886//GO:0005975 vesicle-mediated transport//intracellular protein transport//carbohydrate metabolic process GO:0004553//GO:0005198//GO:0005515//GO:0000049 hydrolase activity, hydrolyzing O-glycosyl compounds//structural molecule activity//protein binding//tRNA binding GO:0030117 membrane coat KOG0273 Beta-transducin family (WD-40 repeat) protein Cluster-8309.21285 BF_2 182.67 3.30 2605 642938002 XP_008199166.1 582 5.5e-57 PREDICTED: uncharacterized protein LOC103314560 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 197 1.0e-13 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21292 BF_2 146.87 1.12 5780 91077028 XP_967318.1 1305 1.8e-140 PREDICTED: moesin/ezrin/radixin homolog 1 [Tribolium castaneum]>gi|270002017|gb|EEZ98464.1| hypothetical protein TcasGA2_TC000955 [Tribolium castaneum] -- -- -- -- -- K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 988 4.2e-105 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF00887//PF04281//PF05531//PF02911//PF00551//PF00769 Acyl CoA binding protein//Mitochondrial import receptor subunit Tom22//Nucleopolyhedrovirus P10 protein//Formyl transferase, C-terminal domain//Formyl transferase//Ezrin/radixin/moesin family GO:0009058//GO:0006886 biosynthetic process//intracellular protein transport GO:0016742//GO:0008092//GO:0000062 hydroxymethyl-, formyl- and related transferase activity//cytoskeletal protein binding//fatty-acyl-CoA binding GO:0005741//GO:0005737//GO:0019028//GO:0019898 mitochondrial outer membrane//cytoplasm//viral capsid//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.21293 BF_2 201.75 135.61 344 728417870 AIY68350.1 385 5.1e-35 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P35502 319 9.4e-29 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.21295 BF_2 376.04 3.25 5124 478250642 ENN71134.1 2858 0.0e+00 hypothetical protein YQE_12065, partial [Dendroctonus ponderosae]>gi|546674775|gb|ERL86072.1| hypothetical protein D910_03486 [Dendroctonus ponderosae] -- -- -- -- -- K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 Q13200 2129 1.8e-237 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 PF12937//PF00328 F-box-like//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0003993 protein binding//acid phosphatase activity -- -- KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.21296 BF_2 60.20 3.56 994 835482914 AKM70276.1 147 5.8e-07 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21297 BF_2 3.00 0.34 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21305 BF_2 61.00 6.86 659 166851830 NP_001107779.1 691 3.2e-70 bursicon precursor [Tribolium castaneum]>gi|74325216|gb|ABA03053.1| bursicon [Tribolium castaneum]>gi|270008186|gb|EFA04634.1| bursicon [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VD83 578 1.7e-58 Bursicon OS=Drosophila melanogaster GN=Burs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21306 BF_2 4118.00 113.42 1806 748995284 AJE75664.1 1834 2.5e-202 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1090 2.0e-117 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00331//PF00232//PF00150 Glycosyl hydrolase family 10//Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21307 BF_2 244.39 2.36 4628 642925855 XP_008190573.1 1955 6.1e-216 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K06171 NCSTN nicastrin http://www.genome.jp/dbget-bin/www_bget?ko:K06171 Q9VC27 1091 3.8e-117 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF00328//PF05450 Histidine phosphatase superfamily (branch 2)//Nicastrin GO:0016485//GO:0006771//GO:0019497 protein processing//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane KOG2657 Transmembrane glycoprotein nicastrin Cluster-8309.21308 BF_2 68.00 3.18 1181 642936663 XP_008198528.1 758 9.8e-78 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10859 ALKBH2 alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10859 Q6P6J4 582 1.0e-58 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 OS=Mus musculus GN=Alkbh2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2131 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21310 BF_2 297.00 4.78 2888 642937884 XP_008200340.1 2011 1.2e-222 PREDICTED: F-box/LRR-repeat protein 6 isoform X1 [Tribolium castaneum]>gi|642937886|ref|XP_008200341.1| PREDICTED: F-box/LRR-repeat protein 6 isoform X1 [Tribolium castaneum]>gi|642937890|ref|XP_008200344.1| PREDICTED: F-box/LRR-repeat protein 6 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10272 FBXL6 F-box and leucine-rich repeat protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10272 Q8N531 528 4.6e-52 F-box/LRR-repeat protein 6 OS=Homo sapiens GN=FBXL6 PE=2 SV=1 PF13855//PF12937//PF00646 Leucine rich repeat//F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.21315 BF_2 138.34 2.65 2469 189241024 XP_970684.2 1458 1.4e-158 PREDICTED: negative elongation factor A isoform X2 [Tribolium castaneum] 642935140 XM_965591.3 295 1.14271e-150 PREDICTED: Tribolium castaneum negative elongation factor A (LOC659266), transcript variant X2, mRNA K15179 WHSC2, NELFA negative elongation factor A http://www.genome.jp/dbget-bin/www_bget?ko:K15179 Q86NP2 1083 1.7e-116 Negative elongation factor A OS=Drosophila melanogaster GN=Nelf-A PE=1 SV=2 PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.21316 BF_2 51.97 0.83 2892 189241024 XP_970684.2 1019 1.3e-107 PREDICTED: negative elongation factor A isoform X2 [Tribolium castaneum] 642935140 XM_965591.3 241 1.39853e-120 PREDICTED: Tribolium castaneum negative elongation factor A (LOC659266), transcript variant X2, mRNA K15179 WHSC2, NELFA negative elongation factor A http://www.genome.jp/dbget-bin/www_bget?ko:K15179 Q86NP2 826 1.3e-86 Negative elongation factor A OS=Drosophila melanogaster GN=Nelf-A PE=1 SV=2 PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.21322 BF_2 112.48 0.93 5342 642919913 XP_008192122.1 1315 1.1e-141 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] 759081689 XM_011352406.1 129 4.73301e-58 PREDICTED: Cerapachys biroi transcription factor SOX-5 (LOC105287028), mRNA K09269 SOX5_6_13 transcription factor SOX5/6/13 (SOX group D) http://www.genome.jp/dbget-bin/www_bget?ko:K09269 P35712 523 3.2e-51 Transcription factor SOX-6 OS=Homo sapiens GN=SOX6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0528 HMG-box transcription factor SOX5 Cluster-8309.21329 BF_2 12.95 0.42 1567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21330 BF_2 24.14 0.34 3270 642933809 XP_008197363.1 653 4.1e-65 PREDICTED: G-protein coupled receptor 143 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70259 158 4.2e-09 G-protein coupled receptor 143 OS=Mus musculus GN=Gpr143 PE=2 SV=1 PF01534//PF02101 Frizzled/Smoothened family membrane region//Ocular albinism type 1 protein GO:0007166 cell surface receptor signaling pathway -- -- GO:0016020 membrane -- -- Cluster-8309.21331 BF_2 1499.40 491.16 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.21332 BF_2 468.36 7.95 2751 642911585 XP_967231.3 2292 3.0e-255 PREDICTED: glutaminase kidney isoform, mitochondrial isoform X2 [Tribolium castaneum] 766928101 XM_011497776.1 158 1.83286e-74 PREDICTED: Ceratosolen solmsi marchali glutaminase kidney isoform, mitochondrial (LOC105360775), mRNA K01425 glsA, GLS glutaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01425 P13264 1459 4.8e-160 Glutaminase kidney isoform, mitochondrial OS=Rattus norvegicus GN=Gls PE=1 SV=2 PF04960//PF13606//PF00023 Glutaminase//Ankyrin repeat//Ankyrin repeat GO:0006541 glutamine metabolic process GO:0004359//GO:0005515 glutaminase activity//protein binding -- -- KOG0506 Glutaminase (contains ankyrin repeat) Cluster-8309.21333 BF_2 37.49 0.88 2066 642911585 XP_967231.3 1719 6.3e-189 PREDICTED: glutaminase kidney isoform, mitochondrial isoform X2 [Tribolium castaneum] 766928101 XM_011497776.1 109 2.37769e-47 PREDICTED: Ceratosolen solmsi marchali glutaminase kidney isoform, mitochondrial (LOC105360775), mRNA K01425 glsA, GLS glutaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01425 Q19013 1122 4.4e-121 Putative glutaminase 2 OS=Caenorhabditis elegans GN=glna-2 PE=3 SV=2 PF04960 Glutaminase GO:0006541 glutamine metabolic process GO:0004359 glutaminase activity -- -- KOG0506 Glutaminase (contains ankyrin repeat) Cluster-8309.21334 BF_2 95.09 2.76 1727 642920590 XP_008192477.1 728 4.3e-74 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 543 5.0e-54 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.21335 BF_2 142.00 2.73 2461 91079258 XP_971676.1 1749 2.5e-192 PREDICTED: homeobox protein caupolican [Tribolium castaneum] 642916739 XM_966583.2 477 0 PREDICTED: Tribolium castaneum homeobox protein caupolican (LOC660345), mRNA -- -- -- -- P54269 540 1.6e-53 Homeobox protein caupolican OS=Drosophila melanogaster GN=caup PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.21339 BF_2 339.00 12.28 1442 332374188 AEE62235.1 613 7.8e-61 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08666 KLK4, PRSS17 kallikrein 4 (prostase, enamel matrix, prostate) http://www.genome.jp/dbget-bin/www_bget?ko:K08666 Q00871 460 1.8e-44 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21340 BF_2 110.79 2.26 2341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21344 BF_2 16.82 0.93 1044 91087535 XP_970133.1 317 1.2e-26 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] -- -- -- -- -- K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 185 9.8e-13 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 -- -- GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.21347 BF_2 58.60 0.32 7961 641658099 XP_008180596.1 937 1.2e-97 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 642920823 XM_008194352.1 45 3.50365e-11 PREDICTED: Tribolium castaneum transcription factor SPT20 homolog (LOC661459), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 886 3.9e-93 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF13912//PF12090//PF04810//PF00412//PF12833//PF02892//PF16622//PF00096 Zinc-finger double domain//C2H2-type zinc finger//Spt20 family//Sec23/Sec24 zinc finger//LIM domain//Helix-turn-helix domain//BED zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0003712//GO:0043565//GO:0003700//GO:0046872//GO:0003677 zinc ion binding//transcription cofactor activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//DNA binding GO:0030127//GO:0005667//GO:0000124 COPII vesicle coat//transcription factor complex//SAGA complex -- -- Cluster-8309.21351 BF_2 82.00 0.45 7874 607361355 EZA55644.1 805 2.3e-82 hypothetical protein X777_04316 [Cerapachys biroi] 795019032 XM_012004052.1 63 3.4165e-21 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556938 (LOC105556938), mRNA -- -- -- -- -- -- -- -- PF03175//PF03184//PF00982 DNA polymerase type B, organellar and viral//DDE superfamily endonuclease//Glycosyltransferase family 20 GO:0006260//GO:0005992 DNA replication//trehalose biosynthetic process GO:0003676//GO:0008408//GO:0000166//GO:0003677//GO:0003824//GO:0003887 nucleic acid binding//3'-5' exonuclease activity//nucleotide binding//DNA binding//catalytic activity//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.21354 BF_2 6.55 0.65 707 751241840 XP_011175043.1 271 1.7e-21 PREDICTED: uncharacterized protein LOC105207312, partial [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21355 BF_2 8.20 1.63 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21356 BF_2 3118.69 96.94 1633 642921550 XP_008192419.1 847 6.5e-88 PREDICTED: homeobox protein Nkx-2.2 isoform X2 [Tribolium castaneum] 780639346 XM_011689294.1 81 6.87283e-32 PREDICTED: Wasmannia auropunctata homeobox protein Nkx-2.5-like (LOC105449864), transcript variant X2, mRNA K08029 NKX2-2 homeobox protein Nkx-2.2 http://www.genome.jp/dbget-bin/www_bget?ko:K08029 P42587 419 1.1e-39 Homeobox protein XENK-2 OS=Xenopus laevis PE=2 SV=1 PF00046//PF03595 Homeobox domain//Voltage-dependent anion channel GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0016021 integral component of membrane KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain Cluster-8309.21357 BF_2 1521.00 78.96 1093 546685307 ERL94834.1 750 7.7e-77 hypothetical protein D910_12107 [Dendroctonus ponderosae] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q8VBX1 404 4.2e-38 Endothelial lipase OS=Rattus norvegicus GN=Lipg PE=2 SV=2 PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.21358 BF_2 2.00 2.09 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21359 BF_2 26.52 0.48 2596 91080493 XP_970962.1 1359 4.4e-147 PREDICTED: bestrophin-3 [Tribolium castaneum]>gi|270005768|gb|EFA02216.1| hypothetical protein TcasGA2_TC007875 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8BGM5 883 2.8e-93 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.21360 BF_2 66.01 0.85 3534 91090524 XP_970076.1 662 4.0e-66 PREDICTED: coenzyme Q-binding protein COQ10 homolog B, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18588 COQ10 coenzyme Q-binding protein COQ10 http://www.genome.jp/dbget-bin/www_bget?ko:K18588 Q6DFA6 448 1.1e-42 Coenzyme Q-binding protein COQ10 homolog A, mitochondrial OS=Xenopus laevis GN=coq10b-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3177 Oligoketide cyclase/lipid transport protein Cluster-8309.21361 BF_2 19.84 0.41 2300 91080493 XP_970962.1 895 2.5e-93 PREDICTED: bestrophin-3 [Tribolium castaneum]>gi|270005768|gb|EFA02216.1| hypothetical protein TcasGA2_TC007875 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8NFU1 611 8.7e-62 Bestrophin-2 OS=Homo sapiens GN=BEST2 PE=2 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.21363 BF_2 168.83 3.80 2147 91080493 XP_970962.1 1396 1.9e-151 PREDICTED: bestrophin-3 [Tribolium castaneum]>gi|270005768|gb|EFA02216.1| hypothetical protein TcasGA2_TC007875 [Tribolium castaneum] -- -- -- -- -- K13878 BEST1, VMD2 bestrophin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K13878 Q8BGM5 883 2.3e-93 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.21369 BF_2 38.44 0.38 4526 270012558 EFA09006.1 1521 1.3e-165 hypothetical protein TcasGA2_TC006714 [Tribolium castaneum] 850480667 CP011888.1 37 5.56076e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 822 5.8e-86 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF00268//PF09061 Ribonucleotide reductase, small chain//Stirrup GO:0055114//GO:0009186 oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.2137 BF_2 8.59 0.53 967 642925736 XP_008201526.1 828 6.1e-86 PREDICTED: group 3 secretory phospholipase A2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 P80003 265 4.8e-22 Acidic phospholipase A2 PA4 OS=Heloderma suspectum PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21370 BF_2 193.00 4.53 2070 189241108 XP_972242.2 1446 2.9e-157 PREDICTED: U3 small nucleolar ribonucleoprotein protein IMP4 isoform X1 [Tribolium castaneum]>gi|270013895|gb|EFA10343.1| hypothetical protein TcasGA2_TC012561 [Tribolium castaneum] -- -- -- -- -- K14561 IMP4 U3 small nucleolar ribonucleoprotein protein IMP4 http://www.genome.jp/dbget-bin/www_bget?ko:K14561 Q0VD01 906 4.9e-96 U3 small nucleolar ribonucleoprotein protein IMP4 OS=Bos taurus GN=IMP4 PE=2 SV=1 PF09360 Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG2781 U3 small nucleolar ribonucleoprotein (snoRNP) component Cluster-8309.21372 BF_2 514.00 1482.11 271 170041612 XP_001848550.1 146 2.0e-07 conserved hypothetical protein [Culex quinquefasciatus]>gi|167865188|gb|EDS28571.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21374 BF_2 17.00 0.84 1131 91076754 XP_973519.1 176 2.9e-10 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.21375 BF_2 1054.00 19.94 2498 642925444 XP_008194557.1 1690 1.8e-185 PREDICTED: uncharacterized protein LOC662547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16796 790 1.7e-82 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF00843//PF01431//PF05649 Arenavirus nucleocapsid protein//Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity GO:0019013 viral nucleocapsid KOG3624 M13 family peptidase Cluster-8309.21377 BF_2 99.00 52.96 362 195030306 XP_001988009.1 200 1.5e-13 GH10934 [Drosophila grimshawi]>gi|193904009|gb|EDW02876.1| GH10934 [Drosophila grimshawi] -- -- -- -- -- -- -- -- -- D2WKD9 164 9.3e-11 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00608//PF00106 Adenoviral fibre protein (repeat/shaft region)//short chain dehydrogenase GO:0007155//GO:0008152//GO:0009405//GO:0019062 cell adhesion//metabolic process//pathogenesis//virion attachment to host cell GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.21379 BF_2 72.67 0.36 8838 270010529 EFA06977.1 3404 0.0e+00 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929423 XM_008197612.1 78 1.75999e-29 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9UIF8 496 7.2e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF00130//PF00439//PF08926//PF06638//PF04574//PF16866//PF00628//PF01221//PF01429 Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain//Domain of unknown function (DUF1908)//Strabismus protein//Protein of unknown function (DUF592)//PHD-finger//PHD-finger//Dynein light chain type 1//Methyl-CpG binding domain GO:0007017//GO:0006355//GO:0035556//GO:0006468//GO:0009069//GO:0006807//GO:0006342//GO:0006476//GO:0007275//GO:0016310 microtubule-based process//regulation of transcription, DNA-templated//intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//nitrogen compound metabolic process//chromatin silencing//protein deacetylation//multicellular organismal development//phosphorylation GO:0008270//GO:0004674//GO:0005524//GO:0016811//GO:0017136//GO:0000287//GO:0003677//GO:0051287//GO:0005515 zinc ion binding//protein serine/threonine kinase activity//ATP binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD-dependent histone deacetylase activity//magnesium ion binding//DNA binding//NAD binding//protein binding GO:0005875//GO:0016021//GO:0000118//GO:0005634 microtubule associated complex//integral component of membrane//histone deacetylase complex//nucleus KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.21381 BF_2 164.10 1.56 4684 270014851 EFA11299.1 1946 6.8e-215 hypothetical protein TcasGA2_TC010836 [Tribolium castaneum] 642911298 XM_008201139.1 318 3.57367e-163 PREDICTED: Tribolium castaneum forkhead box protein P1-like (LOC657917), transcript variant X2, mRNA K09409 FOXP forkhead box protein P http://www.genome.jp/dbget-bin/www_bget?ko:K09409 Q5W1J5 864 8.2e-91 Forkhead box protein P1 OS=Xenopus laevis GN=foxp1 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG4385 Predicted forkhead transcription factor Cluster-8309.21382 BF_2 766.92 7.83 4382 642911299 XP_008199361.1 2649 1.9e-296 PREDICTED: forkhead box protein P1-like isoform X2 [Tribolium castaneum] 642911298 XM_008201139.1 419 0 PREDICTED: Tribolium castaneum forkhead box protein P1-like (LOC657917), transcript variant X2, mRNA K09409 FOXP forkhead box protein P http://www.genome.jp/dbget-bin/www_bget?ko:K09409 Q5W1J5 874 5.3e-92 Forkhead box protein P1 OS=Xenopus laevis GN=foxp1 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG4385 Predicted forkhead transcription factor Cluster-8309.21386 BF_2 78.00 4.63 992 758213802 AJO62214.1 422 7.5e-39 chemosensory protein CSP8 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q27377 275 3.4e-23 Putative odorant-binding protein A10 OS=Drosophila melanogaster GN=a10 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21390 BF_2 127.00 1.32 4299 563834207 AHB63234.1 4228 0.0e+00 multidrug resistance-associated protein [Phaedon cochleariae] 242021422 XM_002431099.1 37 5.27963e-07 Pediculus humanus corporis Canalicular multispecific organic anion transporter, putative, mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2560 1.6e-287 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00910//PF00664//PF02456//PF13304//PF01926//PF00005//PF03193 RNA helicase//ABC transporter transmembrane region//Adenovirus IVa2 protein//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0019083//GO:0006810 transmembrane transport//viral transcription//transport GO:0016887//GO:0005525//GO:0042626//GO:0003724//GO:0005524//GO:0003723//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//RNA helicase activity//ATP binding//RNA binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.21394 BF_2 6.00 0.83 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.21403 BF_2 23.42 0.37 2942 91085713 XP_972970.1 1384 6.3e-150 PREDICTED: cyclin-H [Tribolium castaneum]>gi|270010021|gb|EFA06469.1| hypothetical protein TcasGA2_TC009354 [Tribolium castaneum] 51776239 AK174982.1 53 4.59021e-16 Ciona intestinalis cDNA, clone:citb089b03, full insert sequence K06634 CCNH cyclin H http://www.genome.jp/dbget-bin/www_bget?ko:K06634 Q9R1A0 581 3.3e-58 Cyclin-H OS=Rattus norvegicus GN=Ccnh PE=2 SV=2 PF05920//PF06687//PF00382//PF01857//PF00046//PF02984 Homeobox KN domain//SUR7/PalI family//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Homeobox domain//Cyclin, C-terminal domain GO:0006355//GO:0000079//GO:0051726 regulation of transcription, DNA-templated//regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of cell cycle GO:0019901//GO:0017025//GO:0003677 protein kinase binding//TBP-class protein binding//DNA binding GO:0005634//GO:0005886//GO:0005675 nucleus//plasma membrane//holo TFIIH complex KOG2496 Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit Cluster-8309.21406 BF_2 6687.21 402.60 982 578359018 AHI15752.1 1281 1.8e-138 glycoside hydrolase family 45 [Apriona japonica] 578359017 KJ186854.1 964 0 Apriona japonica glycoside hydrolase family 45 (gh45-1) mRNA, complete cds -- -- -- -- O97401 746 8.2e-78 Endoglucanase OS=Phaedon cochleariae PE=2 SV=1 PF02015 Glycosyl hydrolase family 45 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.21407 BF_2 78.40 3.04 1367 642921217 XP_008192768.1 482 1.1e-45 PREDICTED: uncharacterized protein LOC656848 isoform X1 [Tribolium castaneum] 642921216 XM_008194546.1 98 2.03149e-41 PREDICTED: Tribolium castaneum uncharacterized LOC656848 (LOC656848), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF02950//PF02819//PF05039 Conotoxin//Spider toxin//Agouti protein GO:0006810//GO:0009405//GO:0009755 transport//pathogenesis//hormone-mediated signaling pathway GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21408 BF_2 151.60 6.02 1340 642921219 XP_968442.2 439 1.1e-40 PREDICTED: uncharacterized protein LOC656848 isoform X2 [Tribolium castaneum]>gi|270005083|gb|EFA01531.1| hypothetical protein TcasGA2_TC007091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02950//PF02819//PF00695//PF05039 Conotoxin//Spider toxin//Major surface antigen from hepadnavirus//Agouti protein GO:0009405//GO:0016032//GO:0009755//GO:0006810 pathogenesis//viral process//hormone-mediated signaling pathway//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21410 BF_2 154.99 6.10 1350 91083833 XP_973697.1 679 1.6e-68 PREDICTED: endocuticle structural glycoprotein SgAbd-8 [Tribolium castaneum]>gi|270006770|gb|EFA03218.1| hypothetical protein TcasGA2_TC013138 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F2 278 2.1e-23 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21412 BF_2 2.00 0.56 436 646696995 KDR08934.1 255 7.6e-20 hypothetical protein L798_01471 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21413 BF_2 171.67 3.39 2403 270009092 EFA05540.1 3503 0.0e+00 hypothetical protein TcasGA2_TC015727 [Tribolium castaneum] 642926476 XM_008193752.1 368 0 PREDICTED: Tribolium castaneum protein suppressor of forked (LOC661644), mRNA K14408 CSTF3, RNA14 cleavage stimulation factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14408 P25991 2430 1.1e-272 Protein suppressor of forked OS=Drosophila melanogaster GN=su(f) PE=1 SV=2 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG1914 mRNA cleavage and polyadenylation factor I complex, subunit RNA14 Cluster-8309.21417 BF_2 62.56 1.74 1793 642916004 XP_008190853.1 1871 1.3e-206 PREDICTED: probable ATP-dependent RNA helicase DDX52 [Tribolium castaneum] -- -- -- -- -- K14779 DDX52, ROK1 ATP-dependent RNA helicase DDX52/ROK1 http://www.genome.jp/dbget-bin/www_bget?ko:K14779 A5D7C1 1299 1.1e-141 Probable ATP-dependent RNA helicase DDX52 OS=Bos taurus GN=DDX52 PE=2 SV=1 PF00270//PF02602//PF12689//PF04851 DEAD/DEAH box helicase//Uroporphyrinogen-III synthase HemD//Acid Phosphatase//Type III restriction enzyme, res subunit GO:0015994//GO:0033014//GO:0006783 chlorophyll metabolic process//tetrapyrrole biosynthetic process//heme biosynthetic process GO:0016791//GO:0003677//GO:0016787//GO:0005524//GO:0004852//GO:0003676 phosphatase activity//DNA binding//hydrolase activity//ATP binding//uroporphyrinogen-III synthase activity//nucleic acid binding -- -- KOG0344 ATP-dependent RNA helicase Cluster-8309.21418 BF_2 21.00 3.72 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21419 BF_2 46.44 1.25 1843 270003649 EFA00097.1 1109 3.0e-118 hypothetical protein TcasGA2_TC002912 [Tribolium castaneum] -- -- -- -- -- K14779 DDX52, ROK1 ATP-dependent RNA helicase DDX52/ROK1 http://www.genome.jp/dbget-bin/www_bget?ko:K14779 A5D7C1 717 3.6e-74 Probable ATP-dependent RNA helicase DDX52 OS=Bos taurus GN=DDX52 PE=2 SV=1 PF04851//PF00270//PF07652 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0019079 viral genome replication GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0008026 ATP binding//DNA binding//hydrolase activity//nucleic acid binding//ATP-dependent helicase activity -- -- KOG0344 ATP-dependent RNA helicase Cluster-8309.21421 BF_2 119.16 3.64 1655 642932331 XP_008197068.1 394 2.2e-35 PREDICTED: uncharacterized protein LOC103314051 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07947//PF06624//PF01284 YhhN-like protein//Ribosome associated membrane protein RAMP4//Membrane-associating domain -- -- -- -- GO:0005783//GO:0016021//GO:0016020 endoplasmic reticulum//integral component of membrane//membrane -- -- Cluster-8309.21422 BF_2 189.83 4.27 2149 270006196 EFA02644.1 460 6.4e-43 hypothetical protein TcasGA2_TC008365 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21425 BF_2 72.34 0.31 9925 642935750 XP_008198157.1 2472 1.5e-275 PREDICTED: rotatin [Tribolium castaneum] -- -- -- -- -- K14301 NUP107, NUP84 nuclear pore complex protein Nup107 http://www.genome.jp/dbget-bin/www_bget?ko:K14301 Q8BH74 735 1.6e-75 Nuclear pore complex protein Nup107 OS=Mus musculus GN=Nup107 PE=2 SV=1 PF04121 Nuclear pore protein 84 / 107 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1964 Nuclear pore complex, rNup107 component (sc Nup84) Cluster-8309.21426 BF_2 3.00 4.38 299 642939494 XP_008190865.1 157 1.2e-08 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005488 binding -- -- -- -- Cluster-8309.21431 BF_2 146.17 4.15 1761 332374188 AEE62235.1 643 3.1e-64 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08666 KLK4, PRSS17 kallikrein 4 (prostase, enamel matrix, prostate) http://www.genome.jp/dbget-bin/www_bget?ko:K08666 P36178 441 3.4e-42 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21433 BF_2 4.24 0.48 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21434 BF_2 127.50 2.45 2468 91090986 XP_974863.1 2212 5.1e-246 PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936123|ref|XP_008198309.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936125|ref|XP_008198310.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|270013188|gb|EFA09636.1| hypothetical protein TcasGA2_TC011759 [Tribolium castaneum] -- -- -- -- -- K11862 ZRANB1, TRABID ubiquitin thioesterase ZRANB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11862 Q9VH90 1726 4.8e-191 Ubiquitin thioesterase trabid OS=Drosophila melanogaster GN=trbd PE=1 SV=1 -- -- -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG4345 NF-kappa B regulator AP20/Cezanne Cluster-8309.21438 BF_2 201.15 3.87 2463 642912504 XP_008200894.1 773 3.7e-79 PREDICTED: F-box/WD repeat-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P57775 425 3.4e-40 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21442 BF_2 275.24 3.99 3174 642917459 XP_008191209.1 3060 0.0e+00 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 971 2.2e-103 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00788//PF00617 Ras association (RalGDS/AF-6) domain//RasGEF domain GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.21444 BF_2 315.59 13.90 1237 91091334 XP_971825.1 811 7.3e-84 PREDICTED: signal recognition particle receptor subunit beta [Tribolium castaneum]>gi|270014143|gb|EFA10591.1| hypothetical protein TcasGA2_TC012850 [Tribolium castaneum] -- -- -- -- -- K12272 SRPRB, SRP102 signal recognition particle receptor subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12272 Q9Y5M8 470 1.0e-45 Signal recognition particle receptor subunit beta OS=Homo sapiens GN=SRPRB PE=1 SV=3 PF01926//PF08477//PF02421//PF04670//PF00025 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG0090 Signal recognition particle receptor, beta subunit (small G protein superfamily) Cluster-8309.21445 BF_2 291.00 9.72 1540 642916382 XP_008190997.1 1144 2.2e-122 PREDICTED: GPN-loop GTPase 2 [Tribolium castaneum]>gi|270003652|gb|EFA00100.1| hypothetical protein TcasGA2_TC002915 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q6PUR6 716 3.9e-74 GPN-loop GTPase 2 OS=Danio rerio GN=gpn2 PE=2 SV=1 PF01926//PF03266//PF07728//PF00448 50S ribosome-binding GTPase//NTPase//AAA domain (dynein-related subfamily)//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0016887//GO:0098519//GO:0005524//GO:0005525//GO:0000166 ATPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//GTP binding//nucleotide binding -- -- KOG1533 Predicted GTPase Cluster-8309.21446 BF_2 3.00 1.26 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21448 BF_2 148.00 6.77 1201 270010058 EFA06506.1 460 3.6e-43 hypothetical protein TcasGA2_TC009405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06839//PF02537 GRF zinc finger//CrcB-like protein, Camphor Resistance (CrcB) -- -- GO:0008270 zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.21449 BF_2 132.72 1.47 4066 642910366 XP_008200294.1 3938 0.0e+00 PREDICTED: myosin-IB [Tribolium castaneum]>gi|270014945|gb|EFA11393.1| hypothetical protein TcasGA2_TC011553 [Tribolium castaneum] 637314166 XM_008113233.1 58 1.05769e-18 PREDICTED: Anolis carolinensis myosin ID (myo1d), transcript variant X2, mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23979 3146 0.0e+00 Myosin-IB OS=Drosophila melanogaster GN=Myo61F PE=1 SV=3 PF00437//PF00485//PF06017//PF00612//PF06414//PF00063//PF07475 Type II/IV secretion system protein//Phosphoribulokinase / Uridine kinase family//Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Zeta toxin//Myosin head (motor domain)//HPr Serine kinase C-terminal domain GO:0000160//GO:0008152//GO:0006810//GO:0006109//GO:0016310 phosphorelay signal transduction system//metabolic process//transport//regulation of carbohydrate metabolic process//phosphorylation GO:0005524//GO:0000155//GO:0005515//GO:0016301//GO:0003774//GO:0004672 ATP binding//phosphorelay sensor kinase activity//protein binding//kinase activity//motor activity//protein kinase activity GO:0016459//GO:0009365 myosin complex//protein histidine kinase complex KOG0164 Myosin class I heavy chain Cluster-8309.21452 BF_2 4868.14 112.21 2102 332375851 AEE63066.1 1355 1.0e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q9UB00 931 6.2e-99 Putative glucosylceramidase 4 OS=Caenorhabditis elegans GN=gba-4 PE=3 SV=2 PF02055//PF02057 O-Glycosyl hydrolase family 30//Glycosyl hydrolase family 59 GO:0006683//GO:0006807//GO:0006665//GO:0005975//GO:0006687 galactosylceramide catabolic process//nitrogen compound metabolic process//sphingolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process GO:0004336//GO:0004348 galactosylceramidase activity//glucosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.21456 BF_2 130.00 14.90 652 642913920 XP_008201214.1 361 5.8e-32 PREDICTED: uncharacterized protein LOC103315121 [Tribolium castaneum]>gi|270001641|gb|EEZ98088.1| hypothetical protein TcasGA2_TC000501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21458 BF_2 269.84 12.38 1199 642928451 XP_972332.2 1470 2.7e-160 PREDICTED: UPF0160 protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58DG1 869 5.5e-92 UPF0160 protein MYG1, mitochondrial OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2948 Predicted metal-binding protein Cluster-8309.21460 BF_2 1246.54 38.63 1637 385199930 AFI45013.1 720 3.4e-73 cytochrome P450 CYP410a1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P29981 541 8.1e-54 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.21461 BF_2 22.64 0.40 2630 91085213 XP_972338.1 2466 1.9e-275 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009080|gb|EFA05528.1| hypothetical protein TcasGA2_TC015715 [Tribolium castaneum] 817051486 XM_012395873.1 121 6.48364e-54 PREDICTED: Athalia rosae glucose dehydrogenase [FAD, quinone] (LOC105683336), mRNA -- -- -- -- P18172 1064 2.9e-114 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05834//PF00732//PF07992//PF01266//PF05199 Lycopene cyclase protein//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase GO:0006563//GO:0006066//GO:0006566//GO:0016117//GO:0006544//GO:0055114 L-serine metabolic process//alcohol metabolic process//threonine metabolic process//carotenoid biosynthetic process//glycine metabolic process//oxidation-reduction process GO:0016614//GO:0016705//GO:0016491//GO:0008812//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.21462 BF_2 346.49 2.66 5735 156123605 ABU50692.1 1864 2.7e-205 cadherin-like protein [Diabrotica virgifera virgifera]>gi|157384055|gb|AAV88529.2| cadherin-like protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- Q9VW71 270 7.5e-22 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF06363//PF00028 Picornaviridae P3A protein//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0019012//GO:0016020 virion//membrane -- -- Cluster-8309.21465 BF_2 29.16 1.99 899 478250096 ENN70602.1 144 1.2e-06 hypothetical protein YQE_12777, partial [Dendroctonus ponderosae]>gi|546674492|gb|ERL85857.1| hypothetical protein D910_03272 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04758 Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.21466 BF_2 173.65 2.45 3253 91084843 XP_966905.1 959 1.3e-100 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 681 9.4e-70 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF03015//PF01073//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0080019//GO:0016616//GO:0003824//GO:0050662//GO:0003854 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.21468 BF_2 33.00 0.88 1856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21469 BF_2 297.05 8.41 1765 91089769 XP_967094.1 1002 7.4e-106 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 2.4e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.21470 BF_2 259.46 1.73 6543 675381743 KFM74645.1 366 1.5e-31 Zinc finger protein 729, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q05481 327 2.1e-28 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF00096//PF13912//PF04810//PF02892//PF00412//PF06305//PF13465//PF07975 Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//LIM domain//Protein of unknown function (DUF1049)//Zinc-finger double domain//TFIIH C1-like domain GO:0006886//GO:0006888//GO:0006281 intracellular protein transport//ER to Golgi vesicle-mediated transport//DNA repair GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005887//GO:0030127 integral component of plasma membrane//COPII vesicle coat -- -- Cluster-8309.21471 BF_2 35.73 0.77 2218 190702371 ACE75264.1 2131 1.1e-236 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- P10582 132 2.9e-06 DNA polymerase OS=Zea mays PE=3 SV=1 PF08509//PF03175 Adenylate cyclase G-alpha binding domain//DNA polymerase type B, organellar and viral GO:0006171//GO:0006144//GO:0006260 cAMP biosynthetic process//purine nucleobase metabolic process//DNA replication GO:0003677//GO:0003887//GO:0008408//GO:0000166//GO:0004016//GO:0000287 DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//nucleotide binding//adenylate cyclase activity//magnesium ion binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.21475 BF_2 2.00 0.44 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21477 BF_2 242.59 2.27 4763 546684811 ERL94393.1 1400 1.4e-151 hypothetical protein D910_11672, partial [Dendroctonus ponderosae] 195134144 XM_002011462.1 124 2.5377e-55 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q9VY99 962 3.6e-102 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF15050//PF04952//PF04928//PF00246 SCIMP protein//Succinylglutamate desuccinylase / Aspartoacylase family//Poly(A) polymerase central domain//Zinc carboxypeptidase GO:0008152//GO:0043631//GO:0006508 metabolic process//RNA polyadenylation//proteolysis GO:0016788//GO:0004652//GO:0004181//GO:0008270 hydrolase activity, acting on ester bonds//polynucleotide adenylyltransferase activity//metallocarboxypeptidase activity//zinc ion binding GO:0097197//GO:0016021//GO:0001772 tetraspanin-enriched microdomain//integral component of membrane//immunological synapse KOG3641 Zinc carboxypeptidase Cluster-8309.21478 BF_2 9168.19 401.67 1242 642920590 XP_008192477.1 1012 3.6e-107 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 777 2.6e-81 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.21484 BF_2 107.45 1.22 3971 642939478 XP_008197026.1 2215 3.7e-246 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 830 6.1e-87 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF04923//PF07690 Ninjurin//Major Facilitator Superfamily GO:0007155//GO:0055085//GO:0042246 cell adhesion//transmembrane transport//tissue regeneration -- -- GO:0016021 integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.21485 BF_2 90.71 3.58 1348 336444952 AEI58573.1 639 7.0e-64 serine protease [Eupolyphaga sinensis] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P35037 561 3.2e-56 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.2149 BF_2 2.00 0.68 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21491 BF_2 216.00 7.89 1433 91095011 XP_969955.1 747 2.2e-76 PREDICTED: transcription initiation factor TFIID subunit 9 [Tribolium castaneum]>gi|270015430|gb|EFA11878.1| hypothetical protein TcasGA2_TC004292 [Tribolium castaneum] -- -- -- -- -- K14535 TAF9 transcription initiation factor TFIID subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14535 Q16594 413 4.9e-39 Transcription initiation factor TFIID subunit 9 OS=Homo sapiens GN=TAF9 PE=1 SV=1 PF03510//PF02291 2C endopeptidase (C24) cysteine protease family//Transcription initiation factor IID, 31kD subunit GO:0006352//GO:0006508 DNA-templated transcription, initiation//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3334 Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) Cluster-8309.21498 BF_2 789.25 14.25 2604 268370072 NP_001161228.1 1717 1.4e-188 phosphatidylinositol glycan, class B [Tribolium castaneum] -- -- -- -- -- K05286 PIGB phosphatidylinositol glycan, class B http://www.genome.jp/dbget-bin/www_bget?ko:K05286 Q9VZM5 1277 5.8e-139 GPI mannosyltransferase 3 OS=Drosophila melanogaster GN=CG12006 PE=2 SV=2 PF10588//PF03901 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Alg9-like mannosyltransferase family GO:0055114 oxidation-reduction process GO:0016757//GO:0016491 transferase activity, transferring glycosyl groups//oxidoreductase activity -- -- KOG1771 GPI-alpha-mannosyltransferase III (GPI10/PIG-B) involved in glycosylphosphatidylinositol anchor biosynthesis Cluster-8309.21499 BF_2 59.00 8.20 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21500 BF_2 28.00 9.54 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08119 Scorpion acidic alpha-KTx toxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21501 BF_2 20716.00 717.48 1495 578359008 AHI15747.1 1704 2.5e-187 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359007 KJ186849.1 1158 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-2) mRNA, complete cds -- -- -- -- O85465 663 5.3e-68 Endoglucanase 5A OS=Bacillus agaradhaerens GN=cel5A PE=1 SV=1 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21504 BF_2 5.00 0.35 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21505 BF_2 63.00 8.21 608 194754227 XP_001959397.1 324 1.1e-27 GF12852 [Drosophila ananassae]>gi|190620695|gb|EDV36219.1| GF12852 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- Q7M4F3 269 1.0e-22 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF09462//PF00379 Mus7/MMS22 family//Insect cuticle protein GO:0006974//GO:0006281//GO:0031297 cellular response to DNA damage stimulus//DNA repair//replication fork processing GO:0042302 structural constituent of cuticle GO:0005634 nucleus -- -- Cluster-8309.21507 BF_2 2192.19 95.64 1246 748995296 AJE75670.1 1533 1.4e-167 putative glycosyl hydrolase [Chrysomela lapponica] 585688740 XM_006820670.1 36 5.39592e-07 PREDICTED: Saccoglossus kowalevskii lactase-phlorizin hydrolase-like (LOC102800751), mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 871 3.3e-92 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.2151 BF_2 2.00 0.33 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21510 BF_2 25.40 0.81 1605 642928334 XP_008195539.1 337 8.7e-29 PREDICTED: lysozyme-like [Tribolium castaneum] 332373991 BT127175.1 49 4.15108e-14 Dendroctonus ponderosae clone DPO0418_A10 unknown mRNA K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 246 1.3e-19 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.21511 BF_2 15.00 1.07 876 270013391 EFA09839.1 1453 1.9e-158 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 105 1.64999e-45 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P10079 206 3.0e-15 Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.21512 BF_2 1533.00 102.14 915 217323618 ACK38176.1 815 1.9e-84 midgut cysteine peptidase, partial [Sphenophorus levis] 501290343 AK416958.1 40 2.34664e-09 Riptortus pedestris mRNA for cathepsin L, complete cds, sequence id: Rped-0107 K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 O97397 793 2.7e-83 Cathepsin L-like proteinase OS=Phaedon cochleariae PE=2 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21513 BF_2 5125.32 151.01 1707 728418332 AIY68365.1 1553 9.2e-170 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 632 2.4e-64 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF01991//PF07859 ATP synthase (E/31 kDa) subunit//alpha/beta hydrolase fold GO:0006119//GO:0015992//GO:0015991//GO:0008152 oxidative phosphorylation//proton transport//ATP hydrolysis coupled proton transport//metabolic process GO:0046961//GO:0016787 proton-transporting ATPase activity, rotational mechanism//hydrolase activity GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.21514 BF_2 1705.61 33.96 2388 728418332 AIY68365.1 1591 5.1e-174 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 622 4.8e-63 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF08563//PF01991 alpha/beta hydrolase fold//P53 transactivation motif//ATP synthase (E/31 kDa) subunit GO:0015992//GO:0015991//GO:0006119//GO:0008152 proton transport//ATP hydrolysis coupled proton transport//oxidative phosphorylation//metabolic process GO:0046961//GO:0005515//GO:0016787 proton-transporting ATPase activity, rotational mechanism//protein binding//hydrolase activity GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.21515 BF_2 199.00 2.23 4014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21516 BF_2 34.96 0.86 1978 91087699 XP_974256.1 900 5.6e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 3.8e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.21517 BF_2 2.00 0.43 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21520 BF_2 118.24 1.93 2847 642919713 XP_008192033.1 1789 6.6e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.6e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.21522 BF_2 3.10 0.31 703 546675101 ERL86351.1 516 6.7e-50 hypothetical protein D910_03759, partial [Dendroctonus ponderosae] -- -- -- -- -- K02899 RP-L27, MRPL27, rpmA large subunit ribosomal protein L27 http://www.genome.jp/dbget-bin/www_bget?ko:K02899 Q99N92 208 1.4e-15 39S ribosomal protein L27, mitochondrial OS=Mus musculus GN=Mrpl27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4600 Mitochondrial ribosomal protein MRP7 (L2) Cluster-8309.21523 BF_2 20.00 0.87 1249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21524 BF_2 452.00 14.13 1625 -- -- -- -- -- 115445322 NM_001052976.1 1595 0 Oryza sativa Japonica Group Os02g0249800 (Os02g0249800) mRNA, complete cds -- -- -- -- P14323 2177 1.6e-243 Glutelin type-B 1 OS=Oryza sativa subsp. japonica GN=GluB1-A PE=2 SV=3 PF03079//PF00190 ARD/ARD' family//Cupin GO:0055114 oxidation-reduction process GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity -- -- -- -- Cluster-8309.21528 BF_2 164.00 3.44 2281 646718890 KDR21193.1 239 2.9e-17 putative helicase senataxin [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00498 FHA domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.2153 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21530 BF_2 103.00 3.65 1467 665806811 XP_008551661.1 539 3.0e-52 PREDICTED: uncharacterized protein LOC103574088 [Microplitis demolitor] -- -- -- -- -- K10706 SETX, ALS4 senataxin http://www.genome.jp/dbget-bin/www_bget?ko:K10706 O94387 475 3.3e-46 Uncharacterized ATP-dependent helicase C29A10.10c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC29A10.10c PE=3 SV=1 PF01443 Viral (Superfamily 1) RNA helicase -- -- GO:0005524 ATP binding -- -- KOG1801 tRNA-splicing endonuclease positive effector (SEN1) Cluster-8309.21533 BF_2 9.60 0.34 1455 332374952 AEE62617.1 620 1.2e-61 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O88994 301 4.9e-26 Mitochondrial amidoxime reducing component 2 OS=Rattus norvegicus GN=Marc2 PE=2 SV=1 PF03473 MOSC domain -- -- GO:0003824//GO:0030151//GO:0030170 catalytic activity//molybdenum ion binding//pyridoxal phosphate binding -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.21535 BF_2 45.59 1.74 1380 332374952 AEE62617.1 680 1.3e-68 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O88994 325 7.6e-29 Mitochondrial amidoxime reducing component 2 OS=Rattus norvegicus GN=Marc2 PE=2 SV=1 PF03473 MOSC domain -- -- GO:0030151//GO:0030170//GO:0003824 molybdenum ion binding//pyridoxal phosphate binding//catalytic activity -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.21536 BF_2 51.43 0.32 7076 642937185 XP_008198729.1 2693 2.5e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.80453e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.4e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF11744//PF05192//PF05033//PF00995//PF00023//PF02068//PF13606 Aluminium activated malate transporter//MutS domain III//Pre-SET motif//Sec1 family//Ankyrin repeat//Plant PEC family metallothionein//Ankyrin repeat GO:0006479//GO:0006554//GO:0006298//GO:0016192//GO:0034968//GO:0006904//GO:0015743 protein methylation//lysine catabolic process//mismatch repair//vesicle-mediated transport//histone lysine methylation//vesicle docking involved in exocytosis//malate transport GO:0030983//GO:0008270//GO:0018024//GO:0005524//GO:0005515 mismatched DNA binding//zinc ion binding//histone-lysine N-methyltransferase activity//ATP binding//protein binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.21539 BF_2 26.66 1.25 1179 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21541 BF_2 12.00 4.40 400 724828822 XP_010362764.1 447 3.8e-42 PREDICTED: uncharacterized protein LOC104663322 [Rhinopithecus roxellana] 545688942 NG_027904.2 400 0 Homo sapiens guanine nucleotide binding protein (G protein), q polypeptide (GNAQ), RefSeqGene on chromosome 9 K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P50148 331 4.4e-30 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homo sapiens GN=GNAQ PE=1 SV=4 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0004871//GO:0019001 GTPase activity//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.21542 BF_2 281.00 2.77 4528 645026360 XP_008212069.1 911 6.8e-95 PREDICTED: uncharacterized protein LOC100680303 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q9Y4A0 155 1.3e-08 Jerky protein homolog-like OS=Homo sapiens GN=JRKL PE=2 SV=2 PF03184//PF15333//PF02796//PF05225//PF07975 DDE superfamily endonuclease//TATA box-binding protein-associated factor 1D//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//TFIIH C1-like domain GO:0006281//GO:0006310//GO:0006355 DNA repair//DNA recombination//regulation of transcription, DNA-templated GO:0000150//GO:0003677//GO:0003676//GO:0008270 recombinase activity//DNA binding//nucleic acid binding//zinc ion binding GO:0005634//GO:0005668 nucleus//RNA polymerase transcription factor SL1 complex -- -- Cluster-8309.21544 BF_2 186.46 2.71 3161 546680809 ERL91015.1 1217 1.6e-130 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1134 2.7e-122 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.21546 BF_2 49.77 0.91 2587 546678697 ERL89265.1 1371 1.8e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.2e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.21547 BF_2 44.51 49.21 313 748995296 AJE75670.1 344 2.6e-30 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 229 2.3e-18 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21549 BF_2 29.16 6.89 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21550 BF_2 51.26 0.40 5697 91086191 XP_971352.1 1528 2.4e-166 PREDICTED: WD repeat-containing protein 92 [Tribolium castaneum]>gi|270010235|gb|EFA06683.1| hypothetical protein TcasGA2_TC009613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29RZ9 1178 3.9e-127 WD repeat-containing protein 92 OS=Bos taurus GN=WDR92 PE=2 SV=1 PF02391//PF00400//PF10741 MoaE protein//WD domain, G-beta repeat//Type II secretion system (T2SS), protein M subtype b GO:0006858//GO:0006777 extracellular transport//Mo-molybdopterin cofactor biosynthetic process GO:0005515 protein binding -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.21552 BF_2 47.83 1.37 1750 270009873 EFA06321.1 443 4.9e-41 hypothetical protein TcasGA2_TC009192 [Tribolium castaneum] -- -- -- -- -- K03635 MOCS2, moaE molybdopterin synthase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03635 B5FXU9 388 4.8e-36 Molybdopterin synthase catalytic subunit OS=Taeniopygia guttata GN=MOCS2 PE=2 SV=1 PF02391 MoaE protein GO:0006777 Mo-molybdopterin cofactor biosynthetic process -- -- -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.21555 BF_2 331.60 10.80 1572 546677956 ERL88689.1 466 9.4e-44 hypothetical protein D910_06072 [Dendroctonus ponderosae] -- -- -- -- -- K00310 SE pyrimidodiazepine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00310 Q9VSL3 157 2.6e-09 Pyrimidodiazepine synthase OS=Drosophila melanogaster GN=se PE=1 SV=1 PF01140//PF05485 Matrix protein (MA), p15//THAP domain -- -- GO:0005198//GO:0003676 structural molecule activity//nucleic acid binding GO:0019028 viral capsid -- -- Cluster-8309.21558 BF_2 442.08 26.85 976 748762529 AJE61312.1 726 4.1e-74 glutathione S-transeferase [Dendroctonus armandi] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VSL3 390 1.6e-36 Pyrimidodiazepine synthase OS=Drosophila melanogaster GN=se PE=1 SV=1 PF02798//PF00462//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG0406 Glutathione S-transferase Cluster-8309.21559 BF_2 12.82 0.66 1104 546672885 ERL84608.1 618 1.6e-61 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 410 8.5e-39 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF00108 Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.2156 BF_2 32.00 1.29 1327 478259952 ENN79754.1 1038 3.7e-110 hypothetical protein YQE_03810, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07168 Ureide permease GO:0071705 nitrogen compound transport -- -- -- -- -- -- Cluster-8309.21561 BF_2 30.22 0.47 2954 189235467 XP_001814003.1 660 5.6e-66 PREDICTED: chymotrypsin-1 [Tribolium castaneum]>gi|270004829|gb|EFA01277.1| serine protease P40 [Tribolium castaneum] -- -- -- -- -- K09635 TMPRSS4 transmembrane protease, serine 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09635 Q7SIG2 428 1.9e-40 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF00089//PF01446 Trypsin//Replication protein GO:0006508//GO:0006260 proteolysis//DNA replication GO:0003677//GO:0004252//GO:0008233 DNA binding//serine-type endopeptidase activity//peptidase activity GO:0005727 extrachromosomal circular DNA -- -- Cluster-8309.21562 BF_2 4.00 0.52 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21565 BF_2 70.50 1.85 1879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21574 BF_2 3.00 0.34 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21575 BF_2 27.39 1.66 979 270002260 EEZ98707.1 161 1.4e-08 hypothetical protein TcasGA2_TC001247 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21577 BF_2 7.35 0.35 1173 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01599 Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.21579 BF_2 582.91 16.47 1768 642911140 XP_008200597.1 608 3.6e-60 PREDICTED: protein phosphatase 1 regulatory subunit SDS22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IIW9 144 9.5e-08 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Xenopus tropicalis GN=lingo1 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21580 BF_2 44.02 0.63 3211 91085809 XP_974684.1 1660 6.8e-182 PREDICTED: protein Wnt-5b [Tribolium castaneum]>gi|270011028|gb|EFA07476.1| hypothetical protein TcasGA2_TC009318 [Tribolium castaneum] -- -- -- -- -- K00444 WNT5 wingless-type MMTV integration site family, member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K00444 Q5NVK2 1071 5.5e-115 Protein Wnt-5b OS=Pongo abelii GN=WNT5B PE=2 SV=1 PF00110//PF07850 wnt family//Renin receptor-like protein GO:0007275//GO:0016055//GO:0007165 multicellular organismal development//Wnt signaling pathway//signal transduction GO:0005102//GO:0004872 receptor binding//receptor activity GO:0005578//GO:0005576//GO:0016021 proteinaceous extracellular matrix//extracellular region//integral component of membrane -- -- Cluster-8309.21582 BF_2 3027.00 106.51 1476 86279353 ABC88772.1 1250 1.1e-134 putative carboxypeptidase A-like [Tenebrio molitor] -- -- -- -- -- K08779 CPA1 carboxypeptidase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K08779 O02350 904 5.9e-96 Zinc carboxypeptidase A 1 OS=Anopheles gambiae GN=AGAP009593 PE=2 SV=3 PF02244//PF00246 Carboxypeptidase activation peptide//Zinc carboxypeptidase GO:0006508 proteolysis GO:0008270//GO:0004181//GO:0004180 zinc ion binding//metallocarboxypeptidase activity//carboxypeptidase activity -- -- KOG2650 Zinc carboxypeptidase Cluster-8309.21584 BF_2 66.00 2.81 1268 91094831 XP_971314.1 1015 1.7e-107 PREDICTED: pre-mRNA-splicing factor SPF27 [Tribolium castaneum]>gi|270006573|gb|EFA03021.1| hypothetical protein TcasGA2_TC010444 [Tribolium castaneum] 571574579 XM_006563437.1 143 1.81515e-66 PREDICTED: Apis mellifera pre-mRNA-splicing factor SPF27 (Bcas2), transcript variant X2, mRNA K12861 BCAS2 pre-mRNA-splicing factor SPF27 http://www.genome.jp/dbget-bin/www_bget?ko:K12861 O75934 631 2.3e-64 Pre-mRNA-splicing factor SPF27 OS=Homo sapiens GN=BCAS2 PE=1 SV=1 PF05700//PF14073 Breast carcinoma amplified sequence 2 (BCAS2)//Centrosome localisation domain of Cep57 GO:0006397 mRNA processing GO:0043015//GO:0042802 gamma-tubulin binding//identical protein binding GO:0045298 tubulin complex KOG3096 Spliceosome-associated coiled-coil protein Cluster-8309.21586 BF_2 83.00 8.56 693 478249916 ENN70423.1 457 4.6e-43 hypothetical protein YQE_12928, partial [Dendroctonus ponderosae] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q9V4U9 432 1.5e-41 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.21587 BF_2 297.00 11.02 1415 73921480 AAZ94270.1 941 7.0e-99 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 624 1.7e-63 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0055114//GO:0006955//GO:0051249 oxidation-reduction process//immune response//regulation of lymphocyte activation GO:0046872//GO:0005506//GO:0020037//GO:0016491//GO:0016705 metal ion binding//iron ion binding//heme binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.21588 BF_2 4.00 0.40 703 326668135 XP_002663225.2 536 3.2e-52 PREDICTED: uncharacterized protein K02A2.6-like [Danio rerio] -- -- -- -- -- -- -- -- -- Q09575 383 7.3e-36 Uncharacterized protein K02A2.6 OS=Caenorhabditis elegans GN=K02A2.6 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.21589 BF_2 1020.00 40.49 1341 748995296 AJE75670.1 1541 1.8e-168 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 836 4.1e-88 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21590 BF_2 170.60 3.74 2194 270011990 EFA08438.1 525 1.9e-50 hypothetical protein TcasGA2_TC006085 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11365 Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy -- -- GO:0005615 extracellular space -- -- Cluster-8309.21591 BF_2 9351.59 590.19 950 478251182 ENN71658.1 471 1.5e-44 hypothetical protein YQE_11756, partial [Dendroctonus ponderosae]>gi|546682140|gb|ERL92121.1| hypothetical protein D910_09441 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 400 1.1e-37 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21601 BF_2 8.13 0.68 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21603 BF_2 196.35 3.09 2941 91083957 XP_975021.1 1142 7.2e-122 PREDICTED: caldesmon [Tribolium castaneum]>gi|270006722|gb|EFA03170.1| hypothetical protein TcasGA2_TC013090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09002 147 7.1e-08 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF02075//PF00836//PF01418 Crossover junction endodeoxyribonuclease RuvC//Stathmin family//Helix-turn-helix domain, rpiR family GO:0006281//GO:0006308//GO:0031110//GO:0006355//GO:0006310 DNA repair//DNA catabolic process//regulation of microtubule polymerization or depolymerization//regulation of transcription, DNA-templated//DNA recombination GO:0004520//GO:0003700 endodeoxyribonuclease activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.21606 BF_2 37.31 0.91 2001 642921550 XP_008192419.1 536 9.1e-52 PREDICTED: homeobox protein Nkx-2.2 isoform X2 [Tribolium castaneum] 780639346 XM_011689294.1 40 5.235e-09 PREDICTED: Wasmannia auropunctata homeobox protein Nkx-2.5-like (LOC105449864), transcript variant X2, mRNA K08029 NKX2-2 homeobox protein Nkx-2.2 http://www.genome.jp/dbget-bin/www_bget?ko:K08029 P42587 280 1.8e-23 Homeobox protein XENK-2 OS=Xenopus laevis PE=2 SV=1 PF03595//PF00046 Voltage-dependent anion channel//Homeobox domain GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0016021 integral component of membrane KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain Cluster-8309.21614 BF_2 198.91 3.05 3016 642938354 XP_008198798.1 565 6.0e-55 PREDICTED: peptidyl-prolyl cis-trans isomerase G [Tribolium castaneum] 645259408 XM_008237125.1 62 4.67392e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 A2AR02 457 8.2e-44 Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus GN=Ppig PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.21615 BF_2 1.00 0.40 391 645018326 XP_008205952.1 181 2.6e-11 PREDICTED: papilin [Nasonia vitripennis] -- -- -- -- -- K15619 SPINT1 Kunitz-type protease inhibitor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15619 Q868Z9 165 7.6e-11 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.21616 BF_2 12.91 0.80 959 571501399 XP_006562821.1 564 2.5e-55 PREDICTED: dipeptidase 1 isoform X1 [Apis mellifera] -- -- -- -- -- K01273 DPEP membrane dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01273 Q3SZM7 376 6.4e-35 Dipeptidase 1 OS=Bos taurus GN=DPEP1 PE=2 SV=1 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.21619 BF_2 187.00 3.81 2338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.21620 BF_2 18.00 1.00 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21623 BF_2 1173.79 27.19 2093 91077618 XP_973779.1 1931 1.7e-213 PREDICTED: protein Malvolio [Tribolium castaneum]>gi|270001554|gb|EEZ98001.1| hypothetical protein TcasGA2_TC000399 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1731 1.1e-191 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01566 Natural resistance-associated macrophage protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.21624 BF_2 370.51 34.76 733 91083431 XP_969550.1 401 1.5e-36 PREDICTED: membrane magnesium transporter 1 [Tribolium castaneum]>gi|270007793|gb|EFA04241.1| hypothetical protein TcasGA2_TC014495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28HV5 263 6.2e-22 Membrane magnesium transporter 1 OS=Xenopus tropicalis GN=mmgt1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3918 Predicted membrane protein Cluster-8309.21625 BF_2 21.03 0.41 2432 91080239 XP_972955.1 1369 2.8e-148 PREDICTED: TNF receptor-associated factor 6 [Tribolium castaneum]>gi|270006403|gb|EFA02851.1| TNF-receptor-associated factor 2 [Tribolium castaneum] -- -- -- -- -- K03175 TRAF6 TNF receptor-associated factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03175 A7XUJ6 378 9.6e-35 TNF receptor-associated factor 6 OS=Sus scrofa GN=TRAF6 PE=2 SV=1 PF11789//PF02176//PF00097//PF12678//PF17123//PF04564//PF14634//PF13639//PF01176//PF15965//PF16685//PF12861 Zinc-finger of the MIZ type in Nse subunit//TRAF-type zinc finger//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//U-box domain//zinc-RING finger domain//Ring finger domain//Translation initiation factor 1A / IF-1//TRAF-like zinc-finger//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0006446//GO:0016567//GO:0006413 regulation of translational initiation//protein ubiquitination//translational initiation GO:0003723//GO:0003743//GO:0061630//GO:0004842//GO:0005515//GO:0008270//GO:0046872 RNA binding//translation initiation factor activity//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//metal ion binding GO:0005680//GO:0005840 anaphase-promoting complex//ribosome -- -- Cluster-8309.21628 BF_2 22.81 0.50 2198 332375851 AEE63066.1 447 2.1e-41 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 G5ECR8 333 1.4e-29 Putative glucosylceramidase 3 OS=Caenorhabditis elegans GN=gba-3 PE=3 SV=1 PF02055//PF02806 O-Glycosyl hydrolase family 30//Alpha amylase, C-terminal all-beta domain GO:0006807//GO:0006665//GO:0005975//GO:0006687 nitrogen compound metabolic process//sphingolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process GO:0003824//GO:0004348//GO:0043169 catalytic activity//glucosylceramidase activity//cation binding -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.21630 BF_2 449.05 6.01 3414 642913638 XP_008201098.1 2740 4.2e-307 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 3.0e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004190//GO:0004553 aspartic-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21631 BF_2 46.51 0.42 4928 642913640 XP_008201099.1 2668 1.4e-298 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum]>gi|642913648|ref|XP_008201103.1| PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 4.3e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.21632 BF_2 71.66 0.67 4775 642913646 XP_008201102.1 2668 1.3e-298 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 4.2e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF01055//PF03539 Glycosyl hydrolases family 31//Spumavirus aspartic protease (A9) GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004190//GO:0004553 aspartic-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21633 BF_2 102.68 0.90 5069 642913640 XP_008201099.1 2668 1.4e-298 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum]>gi|642913648|ref|XP_008201103.1| PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 4.4e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF03539//PF01055 Spumavirus aspartic protease (A9)//Glycosyl hydrolases family 31 GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.21634 BF_2 219.13 2.18 4494 642926793 XP_008195018.1 3653 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 61 2.51479e-20 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2149 7.7e-240 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01068//PF00023//PF00651//PF13606 ATP dependent DNA ligase domain//Ankyrin repeat//BTB/POZ domain//Ankyrin repeat GO:0006281//GO:0006310//GO:0006260 DNA repair//DNA recombination//DNA replication GO:0003910//GO:0005515//GO:0005524 DNA ligase (ATP) activity//protein binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.21636 BF_2 38.00 1136.46 208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21637 BF_2 11511.18 1247.98 673 728418268 AIY68363.1 609 1.1e-60 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 P16854 434 8.5e-42 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.21638 BF_2 565.54 82.46 574 728417299 AIY68339.1 427 1.1e-39 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P16854 298 4.3e-26 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21639 BF_2 157.38 5.76 1431 728417299 AIY68339.1 689 1.2e-69 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 Q86GC8 258 4.6e-21 Acetylcholinesterase OS=Culex pipiens GN=ACHE1 PE=2 SV=2 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.21640 BF_2 8.28 0.68 800 761632683 AJP62542.1 345 5.1e-30 carboxylesterase [Oxya chinensis] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 Q64285 294 1.7e-25 Bile salt-activated lipase OS=Mus musculus GN=Cel PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21641 BF_2 9311.16 399.97 1261 728417299 AIY68339.1 676 3.4e-68 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P04058 222 6.1e-17 Acetylcholinesterase OS=Torpedo californica GN=ache PE=1 SV=2 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.21644 BF_2 166.00 3.40 2330 531446594 AGT57844.1 1395 2.6e-151 cytochrome P450 315a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10722 SAD, CYP315A1 ecdysteroid 2-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10722 Q9VGH1 855 4.5e-90 Cytochrome P450 315a1, mitochondrial OS=Drosophila melanogaster GN=sad PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.21645 BF_2 37.00 1.75 1172 16903179 AAK61417.1 455 1.3e-42 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21651 BF_2 14315.00 478.36 1539 546676332 ERL87359.1 234 7.3e-17 hypothetical protein D910_04754 [Dendroctonus ponderosae]>gi|546686977|gb|ERL95934.1| hypothetical protein D910_00624 [Dendroctonus ponderosae]>gi|546687061|gb|ERL95972.1| hypothetical protein D910_00716 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21652 BF_2 12.03 0.99 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21654 BF_2 576.53 5.84 4419 642923817 XP_001816010.2 2335 5.0e-260 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 1.68281e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q5RED8 1071 7.6e-115 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Pongo abelii GN=CYLD PE=2 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG3556 Familial cylindromatosis protein Cluster-8309.21656 BF_2 51.23 0.66 3530 642911317 XP_008199368.1 226 1.4e-15 PREDICTED: uncharacterized protein LOC103314647 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064//PF09508 Sleepless protein//Lacto-N-biose phosphorylase GO:0030431//GO:1903818//GO:0032222 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235//GO:0016758 GPI anchor binding//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.21657 BF_2 71.95 2.99 1295 478255254 ENN75483.1 965 1.1e-101 hypothetical protein YQE_08032, partial [Dendroctonus ponderosae]>gi|546681559|gb|ERL91630.1| hypothetical protein D910_08960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JJ06 231 5.7e-18 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Mus musculus GN=C1galt1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2246 Galactosyltransferases Cluster-8309.21658 BF_2 244.00 415.49 292 -- -- -- -- -- 51535453 AP003523.3 283 5.70099e-145 Oryza sativa Japonica Group genomic DNA, chromosome 6, PAC clone:P0416A11 -- -- -- -- -- -- -- -- PF09297 NADH pyrophosphatase zinc ribbon domain -- -- GO:0046872//GO:0016787 metal ion binding//hydrolase activity -- -- -- -- Cluster-8309.21661 BF_2 121.00 7.39 972 478256984 ENN77148.1 306 2.1e-25 hypothetical protein YQE_06287, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21662 BF_2 4908.89 200.57 1311 751657284 AJF94901.1 1074 2.5e-114 C1 family cathepsin B33 [Tenebrio molitor] 543271545 XM_005424950.1 99 5.41084e-42 PREDICTED: Geospiza fortis cathepsin B (CTSB), mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 965 4.4e-103 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF03320//PF08127//PF00112//PF03051 Bacterial fructose-1,6-bisphosphatase, glpX-encoded//Peptidase family C1 propeptide//Papain family cysteine protease//Peptidase C1-like family GO:0006508//GO:0015976//GO:0006094//GO:0006000//GO:0050790//GO:0006071//GO:0006013//GO:0006098//GO:0006096 proteolysis//carbon utilization//gluconeogenesis//fructose metabolic process//regulation of catalytic activity//glycerol metabolic process//mannose metabolic process//pentose-phosphate shunt//glycolytic process GO:0008234//GO:0004197//GO:0042132 cysteine-type peptidase activity//cysteine-type endopeptidase activity//fructose 1,6-bisphosphate 1-phosphatase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21664 BF_2 443.56 3.30 5902 642912926 XP_008201309.1 1747 1.0e-191 PREDICTED: LOW QUALITY PROTEIN: RNA polymerase II-associated factor 1 homolog [Tribolium castaneum] 808145633 XM_012318648.1 294 9.90187e-150 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K15174 PAF1 RNA polymerase II-associated factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15174 B3A0N5 1282 3.5e-139 Apyrase OS=Tabanus yao PE=1 SV=1 PF01757//PF02872//PF03985//PF00149 Acyltransferase family//5'-nucleotidase, C-terminal domain//Paf1//Calcineurin-like phosphoesterase GO:0006368//GO:0016570//GO:0009166 transcription elongation from RNA polymerase II promoter//histone modification//nucleotide catabolic process GO:0016747//GO:0016787 transferase activity, transferring acyl groups other than amino-acyl groups//hydrolase activity GO:0016593 Cdc73/Paf1 complex KOG2478 Putative RNA polymerase II regulator Cluster-8309.21666 BF_2 137.00 6.91 1116 478258240 ENN78369.1 177 2.2e-10 hypothetical protein YQE_05171, partial [Dendroctonus ponderosae]>gi|546683440|gb|ERL93246.1| hypothetical protein D910_10542 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00836//PF07464//PF00873//PF00015//PF02601//PF04513//PF00210//PF00430//PF01442//PF05929//PF00669//PF14942//PF01544//PF04614 Stathmin family//Apolipophorin-III precursor (apoLp-III)//AcrB/AcrD/AcrF family//Methyl-accepting chemotaxis protein (MCP) signalling domain//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Ferritin-like domain//ATP synthase B/B' CF(0)//Apolipoprotein A1/A4/E domain//Phage capsid scaffolding protein (GPO) serine peptidase//Bacterial flagellin N-terminal helical region//Organelle biogenesis, Muted-like protein//CorA-like Mg2+ transporter protein//Pex19 protein family GO:0007165//GO:0006879//GO:0055085//GO:0006810//GO:0031110//GO:0015992//GO:0030001//GO:0042157//GO:0071973//GO:0006869//GO:0015986//GO:0006308//GO:0019069 signal transduction//cellular iron ion homeostasis//transmembrane transport//transport//regulation of microtubule polymerization or depolymerization//proton transport//metal ion transport//lipoprotein metabolic process//bacterial-type flagellum-dependent cell motility//lipid transport//ATP synthesis coupled proton transport//DNA catabolic process//viral capsid assembly GO:0005198//GO:0008199//GO:0015078//GO:0008289//GO:0008855//GO:0005215//GO:0046873//GO:0004871 structural molecule activity//ferric iron binding//hydrogen ion transmembrane transporter activity//lipid binding//exodeoxyribonuclease VII activity//transporter activity//metal ion transmembrane transporter activity//signal transducer activity GO:0019028//GO:0009318//GO:0045263//GO:0005777//GO:0019031//GO:0005576//GO:0016020//GO:0031083//GO:0030133 viral capsid//exodeoxyribonuclease VII complex//proton-transporting ATP synthase complex, coupling factor F(o)//peroxisome//viral envelope//extracellular region//membrane//BLOC-1 complex//transport vesicle -- -- Cluster-8309.21667 BF_2 27.00 0.65 2038 642933103 XP_008197259.1 246 4.0e-18 PREDICTED: protein Gawky isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00560 Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21673 BF_2 252.78 9.43 1409 91087465 XP_967435.1 908 4.7e-95 PREDICTED: uncharacterized protein LOC655780 [Tribolium castaneum]>gi|270010660|gb|EFA07108.1| hypothetical protein TcasGA2_TC010098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21678 BF_2 3.00 0.45 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21680 BF_2 280.45 3.41 3723 91081979 XP_968359.1 3692 0.0e+00 PREDICTED: ubiquitin-protein ligase E3C [Tribolium castaneum]>gi|270007369|gb|EFA03817.1| hypothetical protein TcasGA2_TC013932 [Tribolium castaneum] -- -- -- -- -- K10589 UBE3C ubiquitin-protein ligase E3 C http://www.genome.jp/dbget-bin/www_bget?ko:K10589 Q15386 1282 2.2e-139 Ubiquitin-protein ligase E3C OS=Homo sapiens GN=UBE3C PE=1 SV=3 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.21681 BF_2 68.81 0.83 3753 91081979 XP_968359.1 3586 0.0e+00 PREDICTED: ubiquitin-protein ligase E3C [Tribolium castaneum]>gi|270007369|gb|EFA03817.1| hypothetical protein TcasGA2_TC013932 [Tribolium castaneum] -- -- -- -- -- K10589 UBE3C ubiquitin-protein ligase E3 C http://www.genome.jp/dbget-bin/www_bget?ko:K10589 Q15386 1282 2.2e-139 Ubiquitin-protein ligase E3C OS=Homo sapiens GN=UBE3C PE=1 SV=3 PF00612//PF00632 IQ calmodulin-binding motif//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.21682 BF_2 30.00 0.98 1565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21685 BF_2 71.85 0.71 4528 91080113 XP_967415.1 1588 2.1e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit I [Tribolium castaneum]>gi|270003188|gb|EEZ99635.1| hypothetical protein TcasGA2_TC002391 [Tribolium castaneum] 642918634 XM_962322.2 236 1.32385e-117 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 3 subunit I (LOC655760), mRNA K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1315 4.0e-143 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF10766//PF00400//PF10505//PF04053 Multidrug efflux pump-associated protein AcrZ//WD domain, G-beta repeat//NMDA receptor-regulated gene protein 2 C-terminus//Coatomer WD associated region GO:0015893//GO:0006855//GO:0016192//GO:0006886 drug transport//drug transmembrane transport//vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515//GO:0015238 structural molecule activity//protein binding//drug transmembrane transporter activity GO:0030117//GO:0008023//GO:0005886 membrane coat//transcription elongation factor complex//plasma membrane KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.21686 BF_2 125.98 11.51 745 91087295 XP_975560.1 596 3.8e-59 PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum]>gi|642929763|ref|XP_008195964.1| PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V968 522 5.9e-52 MIP18 family protein CG30152 OS=Drosophila melanogaster GN=CG30152 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3381 Uncharacterized conserved protein Cluster-8309.21690 BF_2 4505.07 247.05 1050 332375510 AEE62896.1 600 1.8e-59 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 474 3.1e-46 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21692 BF_2 36.72 1.24 1527 242003361 XP_002422710.1 640 6.1e-64 Lipase 3 precursor, putative [Pediculus humanus corporis]>gi|212505532|gb|EEB09972.1| Lipase 3 precursor, putative [Pediculus humanus corporis] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 500 4.3e-49 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.21693 BF_2 37.00 4.31 646 -- -- -- -- -- 255577621 XM_002529642.1 80 9.46986e-32 Ricinus communis lipid binding protein, putative, mRNA -- -- -- -- Q8W453 214 2.6e-16 Putative lipid-transfer protein DIR1 OS=Arabidopsis thaliana GN=DIR1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21694 BF_2 631.94 605.72 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451//PF08086 Scorpion short toxin, BmKK2//Ergtoxin family GO:0006810//GO:0009405 transport//pathogenesis GO:0019870//GO:0008200 potassium channel inhibitor activity//ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21696 BF_2 244.01 6.44 1871 91087581 XP_971751.1 827 1.5e-85 PREDICTED: peroxisomal membrane protein PMP34 [Tribolium castaneum]>gi|270009432|gb|EFA05880.1| hypothetical protein TcasGA2_TC008692 [Tribolium castaneum] -- -- -- -- -- K13354 SLC25A17, PMP34 solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17 http://www.genome.jp/dbget-bin/www_bget?ko:K13354 O70579 557 1.3e-55 Peroxisomal membrane protein PMP34 OS=Mus musculus GN=Slc25a17 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0769 Predicted mitochondrial carrier protein Cluster-8309.21702 BF_2 232.86 22.10 728 642928994 XP_008195648.1 438 7.7e-41 PREDICTED: eukaryotic translation elongation factor 1 epsilon-1 [Tribolium castaneum] -- -- -- -- -- K15439 EEF1E1, AIMP3 eukaryotic translation elongation factor 1 epsilon-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15439 O43324 218 1.0e-16 Eukaryotic translation elongation factor 1 epsilon-1 OS=Homo sapiens GN=EEF1E1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21703 BF_2 208.67 5.00 2033 478254824 ENN75060.1 1612 1.6e-176 hypothetical protein YQE_08373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DKP5 993 3.9e-106 WD repeat-containing protein 13 OS=Pan troglodytes GN=WDR13 PE=3 SV=1 PF00400//PF02975 WD domain, G-beta repeat//Methylamine dehydrogenase, L chain GO:0055114//GO:0009308 oxidation-reduction process//amine metabolic process GO:0005515//GO:0016638 protein binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0042597 periplasmic space KOG0266 WD40 repeat-containing protein Cluster-8309.21706 BF_2 47.00 0.43 4910 157419138 NP_005553.2 6234 0.0e+00 laminin subunit gamma-2 isoform a precursor [Homo sapiens]>gi|90185107|sp|Q13753.2|LAMC2_HUMAN RecName: Full=Laminin subunit gamma-2; AltName: Full=Cell-scattering factor 140 kDa subunit; Short=CSF 140 kDa subunit; AltName: Full=Epiligrin subunit gamma; AltName: Full=Kalinin subunit gamma; AltName: Full=Kalinin/nicein/epiligrin 100 kDa subunit; AltName: Full=Ladsin 140 kDa subunit; AltName: Full=Laminin B2t chain; AltName: Full=Laminin-5 subunit gamma; AltName: Full=Large adhesive scatter factor 140 kDa subunit; AltName: Full=Nicein subunit gamma; Flags: Precursor>gi|119611553|gb|EAW91147.1| laminin, gamma 2, isoform CRA_b [Homo sapiens] 157419137 NM_005562.2 4901 0 Homo sapiens laminin, gamma 2 (LAMC2), transcript variant 1, mRNA K06246 LAMC2 laminin, gamma 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06246 Q13753 6234 0.0e+00 Laminin subunit gamma-2 OS=Homo sapiens GN=LAMC2 PE=1 SV=2 PF05749 Rubella membrane glycoprotein E2 GO:0007155//GO:0031581//GO:0008544 cell adhesion//hemidesmosome assembly//epidermis development GO:0008201 heparin binding GO:0048471//GO:0005610//GO:0005938//GO:0005607//GO:0005615//GO:0019013//GO:0016021 perinuclear region of cytoplasm//laminin-5 complex//cell cortex//laminin-2 complex//extracellular space//viral nucleocapsid//integral component of membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.21707 BF_2 1580.87 174.10 667 634006997 AHZ59669.1 421 6.6e-39 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 289 5.5e-25 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21708 BF_2 17272.81 753.58 1246 748995296 AJE75670.1 1549 2.0e-169 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 862 3.7e-91 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21709 BF_2 253.49 99.71 392 748995296 AJE75670.1 440 2.4e-41 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 313 5.3e-28 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21710 BF_2 8537.00 234.67 1809 748995278 AJE75661.1 1584 2.5e-173 putative glycosyl hydrolase [Chrysomela lapponica] 462347637 APGK01033869.1 48 1.68699e-13 Dendroctonus ponderosae Seq01033879, whole genome shotgun sequence K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1187 1.1e-128 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00150//PF00232 Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.21711 BF_2 547.00 24.64 1216 584482884 AHJ09939.1 905 9.1e-95 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- Q9Y833 815 1.0e-85 Polygalacturonase 2 OS=Penicillium olsonii GN=PG2 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.21713 BF_2 8133.87 375.63 1193 357216861 AET71138.1 854 7.3e-89 cysteine peptidase isoform b [Sphenophorus levis] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 O97397 832 1.1e-87 Cathepsin L-like proteinase OS=Phaedon cochleariae PE=2 SV=1 PF00112//PF03051//PF02501 Papain family cysteine protease//Peptidase C1-like family//Type II secretion system (T2SS), protein I GO:0015031//GO:0006508//GO:0015628 protein transport//proteolysis//protein secretion by the type II secretion system GO:0004197//GO:0008565//GO:0008234 cysteine-type endopeptidase activity//protein transporter activity//cysteine-type peptidase activity GO:0015627 type II protein secretion system complex KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21714 BF_2 228.00 16.56 863 749779245 XP_011144213.1 387 7.5e-35 PREDICTED: trypsin-1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P35035 324 6.2e-29 Trypsin-1 OS=Anopheles gambiae GN=TRYP1 PE=2 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21715 BF_2 70.02 2.91 1292 546684136 ERL93841.1 247 1.9e-18 hypothetical protein D910_11127, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02102 Deuterolysin metalloprotease (M35) family GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.21718 BF_2 132.96 2.49 2519 642914452 XP_008201682.1 2297 7.3e-256 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RC33 721 1.7e-74 GRAM domain-containing protein 1C OS=Pongo abelii GN=GRAMD1C PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.21719 BF_2 8185.06 197.37 2022 91084843 XP_966905.1 1354 1.3e-146 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 874 2.4e-92 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF01370//PF01073//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0003824//GO:0050662//GO:0003854//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.21720 BF_2 7.00 0.39 1039 700894659 AIU99748.1 367 1.9e-32 mitochondrial cytochrome c oxidase subunit VIa precursor [Litopenaeus vannamei] -- -- -- -- -- K02266 COX6A cytochrome c oxidase subunit 6a http://www.genome.jp/dbget-bin/www_bget?ko:K02266 O13085 251 2.2e-20 Cytochrome c oxidase subunit 6A, mitochondrial OS=Oncorhynchus mykiss PE=3 SV=1 PF02046//PF04093 Cytochrome c oxidase subunit VIa//rod shape-determining protein MreD GO:0006123//GO:0015992//GO:0008360 mitochondrial electron transport, cytochrome c to oxygen//proton transport//regulation of cell shape GO:0004129 cytochrome-c oxidase activity GO:0016021//GO:0005743//GO:0045277//GO:0005751 integral component of membrane//mitochondrial inner membrane//respiratory chain complex IV//mitochondrial respiratory chain complex IV KOG3469 Cytochrome c oxidase, subunit VIa/COX13 Cluster-8309.21721 BF_2 213.22 2.44 3948 646702401 KDR11613.1 2135 7.0e-237 Mothers against decapentaplegic-like protein 4 [Zootermopsis nevadensis] 552954715 KF307635.1 131 2.69758e-59 Pinctada fucata TGF beta signaling pathway factor (smad4) mRNA, complete cds K04501 SMAD4 mothers against decapentaplegic homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04501 Q9GKQ9 1048 3.2e-112 Mothers against decapentaplegic homolog 4 OS=Sus scrofa GN=SMAD4 PE=2 SV=1 PF03165//PF03166 MH1 domain//MH2 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.21722 BF_2 69.68 0.78 4028 189234728 XP_001814259.1 801 3.4e-82 PREDICTED: ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 [Tribolium castaneum]>gi|270001556|gb|EEZ98003.1| hypothetical protein TcasGA2_TC000402 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4D7T3 263 3.4e-21 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 OS=Macropus eugenii GN=ASZ1 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21723 BF_2 95.00 7.86 793 675366016 KFM58918.1 579 3.7e-57 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q7JQ07 294 1.7e-25 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665//PF08094 Integrase core domain//Conotoxin TVIIA/GS family GO:0009405//GO:0006810//GO:0015074 pathogenesis//transport//DNA integration GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.21724 BF_2 4058.81 104.43 1913 546676332 ERL87359.1 237 4.1e-17 hypothetical protein D910_04754 [Dendroctonus ponderosae]>gi|546686977|gb|ERL95934.1| hypothetical protein D910_00624 [Dendroctonus ponderosae]>gi|546687061|gb|ERL95972.1| hypothetical protein D910_00716 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00845//PF00041 Geminivirus BL1 movement protein//Fibronectin type III domain GO:0046740 transport of virus in host, cell to cell GO:0005515//GO:0003677 protein binding//DNA binding GO:0033644 host cell membrane -- -- Cluster-8309.21726 BF_2 13.23 0.78 999 642916711 XP_008192290.1 669 1.7e-67 PREDICTED: protein bric-a-brac 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03800//PF05225 Nuf2 family//helix-turn-helix, Psq domain GO:0007067 mitotic nuclear division GO:0003677 DNA binding GO:0000775 chromosome, centromeric region -- -- Cluster-8309.21729 BF_2 2737.00 86.36 1613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21730 BF_2 11.40 0.54 1176 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21733 BF_2 447.31 2.64 7381 642929587 XP_975389.2 4308 0.0e+00 PREDICTED: uncharacterized protein LOC664289 isoform X3 [Tribolium castaneum] 642929586 XM_970296.2 70 4.11231e-25 PREDICTED: Tribolium castaneum uncharacterized LOC664289 (LOC664289), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21736 BF_2 13.26 0.77 1005 332373724 AEE62003.1 965 8.3e-102 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q60477 439 3.3e-42 Cysteine-rich secretory protein 2 OS=Cavia porcellus GN=CRISP2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21738 BF_2 51.98 0.36 6345 642930581 XP_008198224.1 2620 6.4e-293 PREDICTED: sodium/potassium/calcium exchanger Nckx30C isoform X2 [Tribolium castaneum] 642930580 XM_008200002.1 879 0 PREDICTED: Tribolium castaneum sodium/potassium/calcium exchanger Nckx30C (LOC655611), transcript variant X2, mRNA K13750 SLC24A2, NCKX2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13750 Q9U6A0 2088 1.3e-232 Sodium/potassium/calcium exchanger Nckx30C OS=Drosophila melanogaster GN=Nckx30C PE=2 SV=4 PF01699//PF05438//PF00105//PF02038 Sodium/calcium exchanger protein//Thyrotropin-releasing hormone (TRH)//Zinc finger, C4 type (two domains)//ATP1G1/PLM/MAT8 family GO:0055085//GO:0009755//GO:0006355//GO:0007218//GO:0006811 transmembrane transport//hormone-mediated signaling pathway//regulation of transcription, DNA-templated//neuropeptide signaling pathway//ion transport GO:0005184//GO:0008270//GO:0005216//GO:0043565//GO:0003700 neuropeptide hormone activity//zinc ion binding//ion channel activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005634//GO:0005667//GO:0005576//GO:0016020 integral component of membrane//nucleus//transcription factor complex//extracellular region//membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.21740 BF_2 2.00 0.33 541 546682441 ERL92374.1 145 5.4e-07 hypothetical protein D910_09688 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21741 BF_2 389.00 9.77 1952 546682441 ERL92374.1 683 8.0e-69 hypothetical protein D910_09688 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7ZYB4 220 1.6e-16 Polyadenylate-binding protein-interacting protein 1 OS=Xenopus laevis GN=paip1 PE=1 SV=1 PF02854 MIF4G domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.21744 BF_2 185.00 10.52 1023 91078208 XP_968880.1 1192 4.0e-128 PREDICTED: exosome complex component RRP4 [Tribolium castaneum]>gi|270002359|gb|EEZ98806.1| hypothetical protein TcasGA2_TC001377 [Tribolium castaneum] -- -- -- -- -- K03679 RRP4, EXOSC2 exosome complex component RRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K03679 Q2KID0 821 1.7e-86 Exosome complex component RRP4 OS=Bos taurus GN=EXOSC2 PE=2 SV=1 PF15985//PF10447 KH domain//Exosome component EXOSC1/CSL4 -- -- GO:0003723 RNA binding GO:0000178 exosome (RNase complex) KOG3013 Exosomal 3'-5' exoribonuclease complex, subunit Rrp4 Cluster-8309.21747 BF_2 1042.46 21.14 2350 642911769 XP_967219.2 2576 3.0e-288 PREDICTED: transketolase-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q9D4D4 1885 1.7e-209 Transketolase-like protein 2 OS=Mus musculus GN=Tktl2 PE=2 SV=1 PF00676//PF02780//PF02775//PF13292 Dehydrogenase E1 component//Transketolase, C-terminal domain//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//1-deoxy-D-xylulose-5-phosphate synthase GO:0006694//GO:0016114//GO:0008152 steroid biosynthetic process//terpenoid biosynthetic process//metabolic process GO:0008661//GO:0030976//GO:0016624//GO:0003824 1-deoxy-D-xylulose-5-phosphate synthase activity//thiamine pyrophosphate binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity -- -- KOG0523 Transketolase Cluster-8309.21751 BF_2 186.37 4.37 2071 478250506 ENN71001.1 872 1.0e-90 hypothetical protein YQE_12401, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4F753 368 1.2e-33 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF00326//PF07859//PF03376//PF03403//PF02230//PF01764 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Adenovirus E3B protein//Platelet-activating factor acetylhydrolase, isoform II//Phospholipase/Carboxylesterase//Lipase (class 3) GO:0016042//GO:0006508//GO:0046486//GO:0008152//GO:0006629 lipid catabolic process//proteolysis//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0008236//GO:0003847//GO:0016787 serine-type peptidase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0016020//GO:0008247 membrane//1-alkyl-2-acetylglycerophosphocholine esterase complex KOG1552 Predicted alpha/beta hydrolase Cluster-8309.21753 BF_2 6216.65 110.01 2651 642937608 XP_008199119.1 1735 1.1e-190 PREDICTED: neutral alpha-glucosidase AB-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q9FN05 1298 2.2e-141 Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.21754 BF_2 80.02 1.51 2510 642923611 XP_972526.2 1317 3.1e-142 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X1 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.07203e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 1070 5.7e-115 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.21755 BF_2 2357.00 18.09 5739 270004842 EFA01290.1 2631 3.1e-294 hypothetical protein TcasGA2_TC002984 [Tribolium castaneum] 642915987 XM_008192623.1 178 2.93443e-85 PREDICTED: Tribolium castaneum uncharacterized LOC660816 (LOC660816), mRNA -- -- -- -- P34528 699 1.4e-71 Putative serine protease K12H4.7 OS=Caenorhabditis elegans GN=K12H4.7 PE=3 SV=2 PF05577//PF15757//PF08437 Serine carboxypeptidase S28//Amelotin//Glycosyl transferase family 8 C-terminal GO:0070175//GO:0042475//GO:0009103//GO:0006508 positive regulation of enamel mineralization//odontogenesis of dentin-containing tooth//lipopolysaccharide biosynthetic process//proteolysis GO:0008918//GO:0008236 lipopolysaccharide 3-alpha-galactosyltransferase activity//serine-type peptidase activity -- -- KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.21756 BF_2 639.39 24.86 1363 15420657 AAK97411.1 350 2.3e-30 serine protease-like protein [Anthonomus grandis] -- -- -- -- -- -- -- -- -- Q17004 291 6.6e-25 Serine protease SP24D OS=Anopheles gambiae GN=Sp24D PE=2 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21757 BF_2 13.00 1.49 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21758 BF_2 12.50 0.50 1334 642916443 XP_008191029.1 902 2.2e-94 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum]>gi|642916445|ref|XP_008191030.1| PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 4.9e-41 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF08702//PF00046//PF00606//PF02184 Fibrinogen alpha/beta chain family//Homeobox domain//Herpesvirus Glycoprotein B//HAT (Half-A-TPR) repeat GO:0006396//GO:0030168//GO:0051258//GO:0007165 RNA processing//platelet activation//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0003677 receptor binding//protein binding, bridging//DNA binding GO:0005577//GO:0016020//GO:0005622 fibrinogen complex//membrane//intracellular KOG3850 Predicted membrane protein Cluster-8309.21759 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21761 BF_2 13.26 0.93 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21762 BF_2 112.56 1.91 2751 642937608 XP_008199119.1 1735 1.2e-190 PREDICTED: neutral alpha-glucosidase AB-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q9FN05 1260 5.8e-137 Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.21764 BF_2 23.54 0.40 2747 91086285 XP_967226.1 1396 2.4e-151 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01158 1013 2.5e-108 Luciferin 4-monooxygenase OS=Luciola lateralis PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.21765 BF_2 1729.00 27.68 2900 642921456 XP_008192875.1 1701 1.1e-186 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VD19 769 5.2e-80 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.21766 BF_2 990.97 30.71 1637 315570560 ADU33284.1 1742 1.1e-191 glycoside hydrolase family protein 48 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P50899 1348 2.1e-147 Exoglucanase B OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) GN=cbhB PE=1 SV=1 PF02011 Glycosyl hydrolase family 48 GO:0005985//GO:0005982//GO:0005975//GO:0030245 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process//cellulose catabolic process GO:0004553//GO:0008810 hydrolase activity, hydrolyzing O-glycosyl compounds//cellulase activity -- -- -- -- Cluster-8309.21767 BF_2 2.00 0.67 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21769 BF_2 206.80 5.08 1989 557160153 CDJ27266.1 145 2.0e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 9.0e-07 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21770 BF_2 51.43 0.84 2853 557160153 CDJ27266.1 145 2.8e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.3e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21772 BF_2 45.81 3.37 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.21773 BF_2 60.13 0.94 2968 642911573 XP_008200652.1 1470 6.7e-160 PREDICTED: receptor type guanylyl cyclase-like isoform X1 [Tribolium castaneum] 768406042 XM_011600843.1 174 2.52448e-83 PREDICTED: Aquila chrysaetos canadensis natriuretic peptide receptor 2 (NPR2), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18293 1075 1.8e-115 Atrial natriuretic peptide receptor 1 OS=Mus musculus GN=Npr1 PE=2 SV=2 PF00211//PF07714//PF07701 Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Heme NO binding associated GO:0035556//GO:0009190//GO:0006144//GO:0006468//GO:0006182//GO:0046039 intracellular signal transduction//cyclic nucleotide biosynthetic process//purine nucleobase metabolic process//protein phosphorylation//cGMP biosynthetic process//GTP metabolic process GO:0004672//GO:0016849//GO:0004383 protein kinase activity//phosphorus-oxygen lyase activity//guanylate cyclase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.21776 BF_2 3113.14 108.99 1482 642928615 XP_968715.2 754 3.6e-77 PREDICTED: uncharacterized protein LOC657146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.21777 BF_2 152.94 2.91 2482 478260242 ENN80002.1 177 4.8e-10 hypothetical protein YQE_03563, partial [Dendroctonus ponderosae]>gi|546684043|gb|ERL93766.1| hypothetical protein D910_11052 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21780 BF_2 6.00 0.73 632 -- -- -- -- -- 19919546 AF479105.1 261 2.2333e-132 Juglans nigra 26S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21781 BF_2 31.00 1.60 1099 817058348 XP_012250632.1 665 5.5e-67 PREDICTED: muscle-specific protein 20 [Athalia rosae] 817207248 XM_012424179.1 50 7.83159e-15 PREDICTED: Orussus abietinus muscle-specific protein 20 (LOC105699307), mRNA -- -- -- -- P14318 609 7.1e-62 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.21782 BF_2 144.28 1.32 4877 189236172 XP_967164.2 2056 1.2e-227 PREDICTED: WD repeat-containing and planar cell polarity effector protein fritz [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VQ36 600 3.5e-60 WD repeat-containing and planar cell polarity effector protein fritz OS=Drosophila melanogaster GN=frtz PE=2 SV=1 PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.21783 BF_2 116.78 6.72 1014 642931615 XP_008196657.1 290 1.6e-23 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC4 [Tribolium castaneum] 807033681 XM_004529871.2 62 1.53802e-21 PREDICTED: Ceratitis capitata DNA-directed RNA polymerases I, II, and III subunit RPABC4 (LOC101457024), mRNA K03009 RPB12, POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 http://www.genome.jp/dbget-bin/www_bget?ko:K03009 Q3ZBC0 236 1.2e-18 DNA-directed RNA polymerases I, II, and III subunit RPABC4 OS=Bos taurus GN=POLR2K PE=3 SV=1 PF01155//PF03604 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//DNA directed RNA polymerase, 7 kDa subunit GO:0006206//GO:0006351//GO:0006464//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//cellular protein modification process//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0016151 DNA binding//DNA-directed RNA polymerase activity//nickel cation binding GO:0005730 nucleolus KOG3507 DNA-directed RNA polymerase, subunit RPB7.0 Cluster-8309.21786 BF_2 11892.00 206.43 2697 189241705 XP_967022.2 1947 3.0e-215 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K12317 GANC neutral alpha-glucosidase C http://www.genome.jp/dbget-bin/www_bget?ko:K12317 Q94502 1311 6.9e-143 Neutral alpha-glucosidase AB OS=Dictyostelium discoideum GN=modA PE=3 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.21787 BF_2 137.00 5.38 1352 642938159 XP_008199788.1 242 7.6e-18 PREDICTED: uncharacterized protein LOC103314749 [Tribolium castaneum]>gi|270016493|gb|EFA12939.1| hypothetical protein TcasGA2_TC010486 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478//PF06156 Prominin//Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.21789 BF_2 8.00 4.77 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2179 BF_2 25.00 0.53 2262 642910937 XP_008193473.1 1977 8.3e-219 PREDICTED: oxysterol-binding protein-related protein 2 [Tribolium castaneum]>gi|642910939|ref|XP_008193474.1| PREDICTED: oxysterol-binding protein-related protein 2 [Tribolium castaneum]>gi|642910941|ref|XP_008193475.1| PREDICTED: oxysterol-binding protein-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BXW6 1220 2.1e-132 Oxysterol-binding protein-related protein 1 OS=Homo sapiens GN=OSBPL1A PE=1 SV=2 PF02837 Glycosyl hydrolases family 2, sugar binding domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21790 BF_2 6.06 0.56 736 759098812 XP_011370774.1 311 4.1e-26 PREDICTED: fibroblast growth factor receptor 1 isoform X1 [Pteropus vampyrus] 188219627 NG_007729.1 641 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P11362 311 1.7e-27 Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.21791 BF_2 22382.00 1220.98 1054 578359010 AHI15748.1 1655 8.5e-182 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359009 KJ186850.1 1018 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-3) mRNA, complete cds -- -- -- -- O85465 648 2.0e-66 Endoglucanase 5A OS=Bacillus agaradhaerens GN=cel5A PE=1 SV=1 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21792 BF_2 189.21 5.87 1635 642937407 XP_008198823.1 2267 1.4e-252 PREDICTED: dynamin isoform X2 [Tribolium castaneum] 157115705 XM_001652620.1 261 5.97352e-132 Aedes aegypti AAEL007288-RA partial mRNA K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 1899 2.7e-211 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF02212//PF01031 Dynamin GTPase effector domain//Dynamin central region -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.21796 BF_2 10271.80 186.51 2591 642937608 XP_008199119.1 1735 1.1e-190 PREDICTED: neutral alpha-glucosidase AB-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q9FN05 1298 2.1e-141 Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.21799 BF_2 1219.00 75.90 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21801 BF_2 6.71 1.00 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21802 BF_2 251.07 2.88 3933 642935202 XP_008199688.1 1886 5.2e-208 PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|642935204|ref|XP_008199689.1| PREDICTED: kelch-like ECH-associated protein 1 isoform X2 [Tribolium castaneum]>gi|270014185|gb|EFA10633.1| hypothetical protein TcasGA2_TC016270 [Tribolium castaneum] 642935203 XM_008201467.1 297 1.41389e-151 PREDICTED: Tribolium castaneum kelch-like ECH-associated protein 1 (LOC655908), transcript variant X3, mRNA K10456 KLHL19, KEAP1, INRF2 kelch-like protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10456 Q14145 967 7.8e-103 Kelch-like ECH-associated protein 1 OS=Homo sapiens GN=KEAP1 PE=1 SV=2 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21805 BF_2 136.79 0.90 6651 91094503 XP_971555.1 2926 0.0e+00 PREDICTED: tyrosine-protein kinase Fps85D isoform X2 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1542 2.8e-169 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF10541//PF09432//PF00346//PF05090//PF00069//PF07714 Nuclear envelope localisation domain//Tho complex subunit THP2//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Vitamin K-dependent gamma-carboxylase//Protein kinase domain//Protein tyrosine kinase GO:0055114//GO:0006368//GO:0006406//GO:0017187//GO:0006468 oxidation-reduction process//transcription elongation from RNA polymerase II promoter//mRNA export from nucleus//peptidyl-glutamic acid carboxylation//protein phosphorylation GO:0008488//GO:0004672//GO:0048038//GO:0005524//GO:0016651//GO:0051287 gamma-glutamyl carboxylase activity//protein kinase activity//quinone binding//ATP binding//oxidoreductase activity, acting on NAD(P)H//NAD binding GO:0000446//GO:0016021 nucleoplasmic THO complex//integral component of membrane KOG0194 Protein tyrosine kinase Cluster-8309.21806 BF_2 59.96 1.01 2762 642937838 XP_008200322.1 1804 1.2e-198 PREDICTED: tyrosine-protein kinase Fps85D isoform X1 [Tribolium castaneum]>gi|270000733|gb|EEZ97180.1| hypothetical protein TcasGA2_TC004367 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1166 4.6e-126 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF00435 Spectrin repeat GO:0006468 protein phosphorylation GO:0005515//GO:0004713//GO:0005524 protein binding//protein tyrosine kinase activity//ATP binding -- -- KOG0194 Protein tyrosine kinase Cluster-8309.21808 BF_2 11876.00 317.07 1854 478256984 ENN77148.1 429 2.2e-39 hypothetical protein YQE_06287, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02028//PF00204 BCCT, betaine/carnitine/choline family transporter//DNA gyrase B GO:0006810//GO:0006265 transport//DNA topological change GO:0005215//GO:0003918//GO:0005524//GO:0003677 transporter activity//DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding//DNA binding GO:0016020 membrane -- -- Cluster-8309.21811 BF_2 708.00 25.56 1446 91080935 XP_974194.1 892 3.5e-93 PREDICTED: CD9 antigen [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26499 166 2.2e-10 23 kDa integral membrane protein OS=Schistosoma haematobium PE=2 SV=1 PF04103//PF05767//PF00335 CD20-like family//Poxvirus virion envelope protein A14//Tetraspanin family -- -- -- -- GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-8309.21812 BF_2 4148.00 107.39 1903 332375773 AEE63027.1 1827 1.7e-201 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IW92 981 9.0e-105 Beta-galactosidase-1-like protein 2 OS=Homo sapiens GN=GLB1L2 PE=2 SV=1 PF02449 Beta-galactosidase GO:0006687//GO:0005975//GO:0046486//GO:0006027//GO:0006012 glycosphingolipid metabolic process//carbohydrate metabolic process//glycerolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process GO:0004565 beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.21814 BF_2 539.00 37.16 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21816 BF_2 13.07 0.50 1382 646708358 KDR14705.1 318 1.2e-26 Vascular endothelial growth factor receptor 2 [Zootermopsis nevadensis] -- -- -- -- -- K04363 PDGFRA platelet-derived growth factor receptor alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04363 Q8JFR5 243 2.5e-19 Mast/stem cell growth factor receptor kita OS=Danio rerio GN=kita PE=2 SV=2 PF15352//PF00069//PF07714 Susceptibility to monomelic amyotrophy//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0007052//GO:0031122//GO:0035058 protein phosphorylation//mitotic spindle organization//cytoplasmic microtubule organization//nonmotile primary cilium assembly GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0005813//GO:0097546 centrosome//ciliary base KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.21818 BF_2 820.00 21.24 1902 546680592 ERL90835.1 1450 9.0e-158 hypothetical protein D910_08180 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7Z2Q7 266 7.3e-22 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.21821 BF_2 409.62 22.85 1037 332375064 AEE62673.1 575 1.4e-56 unknown [Dendroctonus ponderosae]>gi|478249845|gb|ENN70352.1| hypothetical protein YQE_12860, partial [Dendroctonus ponderosae]>gi|546671451|gb|ERL83760.1| hypothetical protein D910_00980 [Dendroctonus ponderosae]>gi|546672508|gb|ERL84338.1| hypothetical protein D910_01758 [Dendroctonus ponderosae]>gi|546686966|gb|ERL95929.1| hypothetical protein D910_00611 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 464 4.3e-45 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21825 BF_2 660.00 35.91 1056 478251182 ENN71658.1 616 2.5e-61 hypothetical protein YQE_11756, partial [Dendroctonus ponderosae]>gi|546682140|gb|ERL92121.1| hypothetical protein D910_09441 [Dendroctonus ponderosae] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 Q00871 513 9.2e-51 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21826 BF_2 40771.38 2274.59 1037 546683574 ERL93372.1 588 4.4e-58 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 436 7.7e-42 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21827 BF_2 2.00 0.34 530 332376138 AEE63209.1 295 2.1e-24 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00871 190 1.3e-13 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21829 BF_2 5331.00 648.53 631 478251182 ENN71658.1 364 2.5e-32 hypothetical protein YQE_11756, partial [Dendroctonus ponderosae]>gi|546682140|gb|ERL92121.1| hypothetical protein D910_09441 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 270 8.3e-23 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21830 BF_2 1647.00 247.03 566 546683574 ERL93372.1 145 5.6e-07 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21831 BF_2 33.52 0.65 2459 270010746 EFA07194.1 906 1.4e-94 hypothetical protein TcasGA2_TC010200 [Tribolium castaneum] -- -- -- -- -- K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 197 9.4e-14 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21833 BF_2 41.36 1.48 1460 728418014 AIY68354.1 1140 6.1e-122 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 581 1.7e-58 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.21834 BF_2 43.61 1.02 2084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06929 Rotavirus VP3 protein GO:0016032 viral process GO:0005525 GTP binding GO:0019013 viral nucleocapsid -- -- Cluster-8309.21835 BF_2 42.00 0.88 2274 91090025 XP_967532.1 1264 4.0e-136 PREDICTED: homeobox protein slou [Tribolium castaneum]>gi|270013697|gb|EFA10145.1| hypothetical protein TcasGA2_TC012332 [Tribolium castaneum] 690022837 LM530855.1 37 2.77382e-07 Mesocestoides corti genome assembly M_corti_Specht_Voge ,scaffold MCOS_scaffold0000388 K09309 NKX1 homeobox protein Nkx-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09309 P22807 504 2.2e-49 Homeobox protein slou OS=Drosophila melanogaster GN=slou PE=2 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.21836 BF_2 11.35 5.49 371 91094083 XP_970629.1 347 1.4e-30 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270016176|gb|EFA12624.1| hypothetical protein TcasGA2_TC010257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBV9 215 1.2e-16 Dehydrogenase/reductase SDR family member 11 OS=Bos taurus GN=DHRS11 PE=2 SV=1 PF01272//PF00106//PF01073//PF01370 Transcription elongation factor, GreA/GreB, C-term//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0032784//GO:0008210//GO:0008152//GO:0055114//GO:0006694//GO:0008209//GO:0008207 regulation of DNA-templated transcription, elongation//estrogen metabolic process//metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0003677//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//DNA binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.21837 BF_2 91.63 0.93 4394 91092158 XP_967537.1 1880 2.9e-207 PREDICTED: steroid receptor seven-up, isoforms B/C [Tribolium castaneum]>gi|270015100|gb|EFA11548.1| seven up [Tribolium castaneum] 145228045 EF372598.1 535 0 Callosobruchus maculatus COUP-TF/Svp nuclear hormone receptor (Svp) mRNA, complete cds K08547 NR2F1, TFCOUP1 COUP transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08547 P16375 1629 1.5e-179 Steroid receptor seven-up, isoforms B/C OS=Drosophila melanogaster GN=svp PE=2 SV=1 PF00104//PF00105//PF14554 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains)//VEGF heparin-binding domain GO:0030522//GO:0043401//GO:0006355//GO:0007165 intracellular receptor signaling pathway//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0046872//GO:0003700//GO:0008201//GO:0043565//GO:0008270//GO:0004879//GO:0003707 metal ion binding//transcription factor activity, sequence-specific DNA binding//heparin binding//sequence-specific DNA binding//zinc ion binding//RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding//steroid hormone receptor activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.21838 BF_2 4421.00 1015.60 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07174 Fibronectin-attachment protein (FAP) -- -- GO:0050840 extracellular matrix binding GO:0005576 extracellular region -- -- Cluster-8309.21839 BF_2 577.73 19.72 1513 642928334 XP_008195539.1 512 4.2e-49 PREDICTED: lysozyme-like [Tribolium castaneum] 332373991 BT127175.1 50 1.08652e-14 Dendroctonus ponderosae clone DPO0418_A10 unknown mRNA K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 328 3.7e-29 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.21841 BF_2 7.68 0.38 1139 332374492 AEE62387.1 172 8.4e-10 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21842 BF_2 56.87 2.17 1385 332374492 AEE62387.1 680 1.3e-68 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05109 261 2.0e-21 Venom allergen 5 (Fragment) OS=Polistes annularis PE=1 SV=1 PF07782 DC-STAMP-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.21843 BF_2 226.00 4.93 2205 91090075 XP_969798.1 1544 1.3e-168 PREDICTED: glucoside xylosyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K13676 GXYLT UDP-xylose:glucoside alpha-1,3-xylosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13676 Q810K9 950 4.1e-101 Glucoside xylosyltransferase 2 OS=Mus musculus GN=Gxylt2 PE=2 SV=1 PF01501 Glycosyl transferase family 8 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.21846 BF_2 366.00 5.60 3019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21847 BF_2 9.00 4.22 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21848 BF_2 145.95 1.07 5980 642926648 XP_970736.2 988 1.1e-103 PREDICTED: elongator complex protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGK7 484 1.2e-46 Putative elongator complex protein 1 OS=Drosophila melanogaster GN=Elp1 PE=1 SV=2 PF00637 Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport -- -- -- -- KOG1920 IkappaB kinase complex, IKAP component Cluster-8309.21850 BF_2 74.07 0.75 4404 642923337 XP_008193707.1 2964 0.0e+00 PREDICTED: uncharacterized protein LOC103313102 [Tribolium castaneum]>gi|270007619|gb|EFA04067.1| hypothetical protein TcasGA2_TC014301 [Tribolium castaneum] 170035242 XM_001845428.1 49 1.15454e-13 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P22792 295 7.3e-25 Carboxypeptidase N subunit 2 OS=Homo sapiens GN=CPN2 PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.21854 BF_2 3296.60 180.31 1052 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21855 BF_2 8271.00 405.23 1141 578359014 AHI15750.1 1614 5.2e-177 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359013 KJ186852.1 1045 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-5) mRNA, complete cds -- -- -- -- P07103 592 6.9e-60 Endoglucanase Z OS=Dickeya dadantii (strain 3937) GN=celZ PE=1 SV=2 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21857 BF_2 20.46 0.45 2204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2186 BF_2 14.00 4.08 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02020 eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21861 BF_2 1670.00 50.30 1676 728418332 AIY68365.1 1569 1.3e-171 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 596 3.5e-60 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.21863 BF_2 486.00 19697.34 202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21864 BF_2 35.12 0.36 4374 642910515 XP_971774.3 2330 1.9e-259 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] 642910514 XM_966681.3 50 3.18799e-14 PREDICTED: Tribolium castaneum leucine-rich repeats and immunoglobulin-like domains protein 2 (LOC660451), transcript variant X2, mRNA -- -- -- -- Q52KR2 1432 1.0e-156 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Mus musculus GN=Lrig2 PE=1 SV=1 PF06667//PF13895//PF02924//PF05790 Phage shock protein B//Immunoglobulin domain//Bacteriophage lambda head decoration protein D//Immunoglobulin C2-set domain GO:0009271//GO:0007155//GO:0006355 phage shock//cell adhesion//regulation of transcription, DNA-templated GO:0005515 protein binding GO:0019028//GO:0016021 viral capsid//integral component of membrane -- -- Cluster-8309.21866 BF_2 38.90 0.41 4300 642910515 XP_971774.3 1378 4.5e-149 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] 642910514 XM_966681.3 50 3.13361e-14 PREDICTED: Tribolium castaneum leucine-rich repeats and immunoglobulin-like domains protein 2 (LOC660451), transcript variant X2, mRNA -- -- -- -- Q6P1C6 818 1.6e-85 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Mus musculus GN=Lrig3 PE=1 SV=1 PF05790//PF02924//PF00560//PF13855//PF06667//PF01195//PF13895 Immunoglobulin C2-set domain//Bacteriophage lambda head decoration protein D//Leucine Rich Repeat//Leucine rich repeat//Phage shock protein B//Peptidyl-tRNA hydrolase//Immunoglobulin domain GO:0009271//GO:0007155//GO:0006355 phage shock//cell adhesion//regulation of transcription, DNA-templated GO:0004045//GO:0005515 aminoacyl-tRNA hydrolase activity//protein binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG4194 Membrane glycoprotein LIG-1 Cluster-8309.21867 BF_2 4322.00 1983.61 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21871 BF_2 2371.22 27.60 3881 642924039 XP_008193981.1 2216 2.8e-246 PREDICTED: synaptic vesicle 2-related protein [Tribolium castaneum] 642924038 XM_008195759.1 395 0 PREDICTED: Tribolium castaneum synaptic vesicle 2-related protein (LOC100142592), mRNA -- -- -- -- Q9Z2I7 1305 4.9e-142 Synaptic vesicle 2-related protein OS=Rattus norvegicus GN=Svop PE=1 SV=1 PF00083//PF00701//PF07690 Sugar (and other) transporter//Dihydrodipicolinate synthetase family//Major Facilitator Superfamily GO:0008152//GO:0055085 metabolic process//transmembrane transport GO:0022857//GO:0016829 transmembrane transporter activity//lyase activity GO:0016021 integral component of membrane KOG0253 Synaptic vesicle transporter SV2 (major facilitator superfamily) Cluster-8309.21872 BF_2 367.77 2.59 6231 642924039 XP_008193981.1 2263 1.6e-251 PREDICTED: synaptic vesicle 2-related protein [Tribolium castaneum] 642924038 XM_008195759.1 402 0 PREDICTED: Tribolium castaneum synaptic vesicle 2-related protein (LOC100142592), mRNA -- -- -- -- Q9Z2I7 1317 3.2e-143 Synaptic vesicle 2-related protein OS=Rattus norvegicus GN=Svop PE=1 SV=1 PF13409//PF13417//PF00701//PF00083//PF02798//PF07690 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Dihydrodipicolinate synthetase family//Sugar (and other) transporter//Glutathione S-transferase, N-terminal domain//Major Facilitator Superfamily GO:0008152//GO:0055085 metabolic process//transmembrane transport GO:0022857//GO:0005515//GO:0016829 transmembrane transporter activity//protein binding//lyase activity GO:0016021 integral component of membrane KOG0253 Synaptic vesicle transporter SV2 (major facilitator superfamily) Cluster-8309.21874 BF_2 21087.19 1353.30 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21877 BF_2 249.18 8.99 1447 91083615 XP_969779.1 391 4.3e-35 PREDICTED: small nuclear ribonucleoprotein F [Tribolium castaneum]>gi|270007843|gb|EFA04291.1| hypothetical protein TcasGA2_TC014582 [Tribolium castaneum] -- -- -- -- -- K11098 SNRPF, SMF small nuclear ribonucleoprotein F http://www.genome.jp/dbget-bin/www_bget?ko:K11098 Q24297 341 1.1e-30 Small nuclear ribonucleoprotein F OS=Drosophila melanogaster GN=SmF PE=1 SV=2 -- -- GO:0006396 RNA processing -- -- GO:0005634 nucleus KOG3482 Small nuclear ribonucleoprotein (snRNP) SMF Cluster-8309.21880 BF_2 136.00 9.60 880 91083283 XP_974418.1 655 6.4e-66 PREDICTED: pre-rRNA-processing protein esf2 [Tribolium castaneum]>gi|270007726|gb|EFA04174.1| hypothetical protein TcasGA2_TC014423 [Tribolium castaneum] -- -- -- -- -- K14785 ESF2, ABT1 ESF2/ABP1 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K14785 O74362 312 1.6e-27 Pre-rRNA-processing protein esf2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=esf2 PE=1 SV=1 PF00076//PF05985 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ethanolamine ammonia-lyase light chain (EutC) GO:0006520 cellular amino acid metabolic process GO:0008851//GO:0000166//GO:0003676 ethanolamine ammonia-lyase activity//nucleotide binding//nucleic acid binding GO:0009350 ethanolamine ammonia-lyase complex KOG3152 TBP-binding protein, activator of basal transcription (contains rrm motif) Cluster-8309.21881 BF_2 66.00 2.94 1225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21882 BF_2 3.00 0.71 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21885 BF_2 4232.48 297.65 882 264681482 NP_001161130.1 573 2.1e-56 uncharacterized protein LOC660544 precursor [Tribolium castaneum]>gi|262316919|emb|CBC01171.1| chymotrypsin-like proteinase 6A precursor [Tribolium castaneum]>gi|270009251|gb|EFA05699.1| serine protease P155 [Tribolium castaneum] -- -- -- -- -- K09628 PRSS27 protease, serine 27 http://www.genome.jp/dbget-bin/www_bget?ko:K09628 Q2KJ63 338 1.5e-30 Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 PF00089//PF01418 Trypsin//Helix-turn-helix domain, rpiR family GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0004252//GO:0003700//GO:0016787 serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding//hydrolase activity GO:0005667 transcription factor complex -- -- Cluster-8309.21887 BF_2 23.29 0.46 2396 642933276 XP_008197354.1 990 2.5e-104 PREDICTED: cell wall protein RBR3 isoform X1 [Tribolium castaneum] 817211936 XM_012426709.1 59 1.72341e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.0e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21889 BF_2 233.47 7.90 1523 91086841 XP_974159.1 749 1.4e-76 PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum]>gi|642929084|ref|XP_008195684.1| PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum] -- -- -- -- -- K11205 GCLM glutamate--cysteine ligase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11205 P48508 336 4.4e-30 Glutamate--cysteine ligase regulatory subunit OS=Rattus norvegicus GN=Gclm PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3023 Glutamate-cysteine ligase regulatory subunit Cluster-8309.21891 BF_2 6.67 0.61 745 749773946 XP_011142301.1 194 1.5e-12 PREDICTED: uncharacterized protein LOC105184888 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21892 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21893 BF_2 256.00 15.41 982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21894 BF_2 131.64 2.40 2586 642922865 XP_008200429.1 1388 1.9e-150 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum]>gi|642922867|ref|XP_008200430.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1045 4.6e-112 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00004//PF13304//PF01926//PF00664//PF08477//PF04548//PF00236//PF03193//PF00005 ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase//AIG1 family//Glycoprotein hormone//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0007165//GO:0055085//GO:0007264 transport//signal transduction//transmembrane transport//small GTPase mediated signal transduction GO:0005179//GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887 hormone activity//GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.21896 BF_2 35.00 1.83 1088 642934666 XP_008197759.1 385 1.6e-34 PREDICTED: partitioning defective 3 homolog isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21897 BF_2 99.14 0.85 5179 642934658 XP_008197755.1 4108 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.05087e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 446 2.7e-42 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF08727//PF01702//PF00595 Poliovirus 3A protein like//Queuine tRNA-ribosyltransferase//PDZ domain (Also known as DHR or GLGF) GO:0008616//GO:0006144//GO:0006508//GO:0006400 queuosine biosynthetic process//purine nucleobase metabolic process//proteolysis//tRNA modification GO:0008479//GO:0005515//GO:0003968//GO:0004197//GO:0017111 queuine tRNA-ribosyltransferase activity//protein binding//RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.21898 BF_2 6155.00 171.33 1790 728418014 AIY68354.1 1502 7.9e-164 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 Q8QZR3 571 2.9e-57 Pyrethroid hydrolase Ces2a OS=Mus musculus GN=Ces2a PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.21900 BF_2 3203.00 71.73 2155 333470578 AEF33827.1 435 5.1e-40 chymotrypsin-like serine protease 1 [Cherax quadricarinatus] -- -- -- -- -- -- -- -- -- Q00871 426 2.3e-40 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089//PF01484 Trypsin//Nematode cuticle collagen N-terminal domain GO:0006508 proteolysis GO:0042302//GO:0004252 structural constituent of cuticle//serine-type endopeptidase activity -- -- -- -- Cluster-8309.21901 BF_2 44.00 0.97 2185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21903 BF_2 335.11 15.67 1182 751657284 AJF94901.1 1074 2.2e-114 C1 family cathepsin B33 [Tenebrio molitor] 543271545 XM_005424950.1 99 4.86382e-42 PREDICTED: Geospiza fortis cathepsin B (CTSB), mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 965 4.0e-103 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF03320//PF08127//PF00112//PF03051 Bacterial fructose-1,6-bisphosphatase, glpX-encoded//Peptidase family C1 propeptide//Papain family cysteine protease//Peptidase C1-like family GO:0006094//GO:0015976//GO:0006508//GO:0006071//GO:0050790//GO:0006013//GO:0006000//GO:0006096//GO:0006098 gluconeogenesis//carbon utilization//proteolysis//glycerol metabolic process//regulation of catalytic activity//mannose metabolic process//fructose metabolic process//glycolytic process//pentose-phosphate shunt GO:0008234//GO:0004197//GO:0042132 cysteine-type peptidase activity//cysteine-type endopeptidase activity//fructose 1,6-bisphosphate 1-phosphatase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21904 BF_2 342.00 4.75 3302 91076606 XP_968946.1 1532 4.9e-167 PREDICTED: putative maltase-glucoamylase-like protein FLJ16351 [Tribolium castaneum]>gi|270002627|gb|EEZ99074.1| hypothetical protein TcasGA2_TC004953 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M2H8 294 7.2e-25 Probable maltase-glucoamylase 2 OS=Homo sapiens GN=MGAM2 PE=2 SV=3 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21906 BF_2 165.18 1.97 3786 478251121 ENN71597.1 2600 8.0e-291 hypothetical protein YQE_11696, partial [Dendroctonus ponderosae] 543338846 XM_005516267.1 47 1.28218e-12 PREDICTED: Pseudopodoces humilis mitochondrial intermediate peptidase (MIPEP), mRNA K01410 MIPEP mitochondrial intermediate peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01410 Q99797 1794 9.5e-199 Mitochondrial intermediate peptidase OS=Homo sapiens GN=MIPEP PE=1 SV=2 PF08533//PF01432 Beta-galactosidase C-terminal domain//Peptidase family M3 GO:0006027//GO:0006012//GO:0046486//GO:0006687//GO:0006508 glycosaminoglycan catabolic process//galactose metabolic process//glycerolipid metabolic process//glycosphingolipid metabolic process//proteolysis GO:0004565//GO:0004222 beta-galactosidase activity//metalloendopeptidase activity GO:0009341 beta-galactosidase complex KOG2090 Metalloendopeptidase family - mitochondrial intermediate peptidase Cluster-8309.21908 BF_2 11121.00 158.25 3227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041//PF16656//PF01108 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Tissue factor GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.21909 BF_2 17079.12 1624.34 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21910 BF_2 152.11 3.37 2177 817076793 XP_012260690.1 1014 3.7e-107 PREDICTED: uncharacterized protein LOC105688742 [Athalia rosae] -- -- -- -- -- K01298 CPA2 carboxypeptidase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01298 P04069 758 7.4e-79 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.21913 BF_2 25.16 1.06 1284 674304042 AIL23552.1 727 4.2e-74 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q2NL00 386 6.0e-36 Glutathione S-transferase theta-1 OS=Bos taurus GN=GSTT1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0867 Glutathione S-transferase Cluster-8309.21915 BF_2 92.53 1.78 2459 642938252 XP_008198130.1 1486 7.8e-162 PREDICTED: disintegrin and metalloproteinase domain-containing protein 10 isoform X1 [Tribolium castaneum] 642938255 XM_008199910.1 227 7.19679e-113 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 Q8JIY1 635 1.5e-64 Disintegrin and metalloproteinase domain-containing protein 10 OS=Xenopus laevis GN=adam10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.21917 BF_2 7.13 0.31 1250 357216861 AET71138.1 842 1.9e-87 cysteine peptidase isoform b [Sphenophorus levis] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 O97397 802 3.4e-84 Cathepsin L-like proteinase OS=Phaedon cochleariae PE=2 SV=1 PF02501//PF03051//PF00112 Type II secretion system (T2SS), protein I//Peptidase C1-like family//Papain family cysteine protease GO:0015031//GO:0015628//GO:0006508 protein transport//protein secretion by the type II secretion system//proteolysis GO:0004197//GO:0008234//GO:0008565 cysteine-type endopeptidase activity//cysteine-type peptidase activity//protein transporter activity GO:0015627 type II protein secretion system complex KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.21919 BF_2 11511.95 937.20 801 478258771 ENN78795.1 215 6.1e-15 hypothetical protein YQE_04751, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21923 BF_2 6191.32 258.52 1289 264681482 NP_001161130.1 521 3.2e-50 uncharacterized protein LOC660544 precursor [Tribolium castaneum]>gi|262316919|emb|CBC01171.1| chymotrypsin-like proteinase 6A precursor [Tribolium castaneum]>gi|270009251|gb|EFA05699.1| serine protease P155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16651 333 8.4e-30 Prostasin OS=Homo sapiens GN=PRSS8 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0016787//GO:0004252 hydrolase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.21924 BF_2 124.56 3.01 2017 642920590 XP_008192477.1 689 1.7e-69 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 P38571 419 1.4e-39 Lysosomal acid lipase/cholesteryl ester hydrolase OS=Homo sapiens GN=LIPA PE=1 SV=2 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.21925 BF_2 176107.44 5195.93 1705 642920590 XP_008192477.1 919 3.0e-96 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 516 6.7e-51 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.21926 BF_2 42.59 0.68 2900 270003747 EFA00195.1 1464 3.3e-159 hypothetical protein TcasGA2_TC003020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 837 6.8e-88 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.21928 BF_2 32681.00 689.13 2271 546674359 ERL85746.1 647 1.4e-64 hypothetical protein D910_03161 [Dendroctonus ponderosae] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P36178 481 1.0e-46 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.21930 BF_2 5.00 0.71 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21931 BF_2 36.21 0.98 1826 642932696 XP_008196948.1 1243 8.7e-134 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10473//PF06367//PF02183//PF06371 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Diaphanous FH3 Domain//Homeobox associated leucine zipper//Diaphanous GTPase-binding Domain GO:0030036//GO:0006355//GO:0016043 actin cytoskeleton organization//regulation of transcription, DNA-templated//cellular component organization GO:0017048//GO:0003700//GO:0042803//GO:0043565//GO:0008134//GO:0003779//GO:0045502 Rho GTPase binding//transcription factor activity, sequence-specific DNA binding//protein homodimerization activity//sequence-specific DNA binding//transcription factor binding//actin binding//dynein binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.21932 BF_2 5797.00 154.48 1857 768429712 XP_011556047.1 831 5.3e-86 PREDICTED: uncharacterized protein LOC105387071 [Plutella xylostella] -- -- -- -- -- -- -- -- -- F8DVG5 691 3.7e-71 Sucrose-6-phosphate hydrolase OS=Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1) GN=sacA PE=3 SV=1 PF04616 Glycosyl hydrolases family 43 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0228 Beta-fructofuranosidase (invertase) Cluster-8309.21934 BF_2 21.24 0.42 2421 546682217 ERL92178.1 1152 4.1e-123 hypothetical protein D910_09498 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q02942 356 3.4e-32 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21935 BF_2 12.69 0.58 1200 157131660 XP_001655912.1 535 7.2e-52 AAEL012172-PA [Aedes aegypti]>gi|157131662|ref|XP_001655913.1| AAEL012179-PA [Aedes aegypti]>gi|122127167|sp|Q16MW6.1|MTAP_AEDAE RecName: Full=S-methyl-5'-thioadenosine phosphorylase; AltName: Full=5'-methylthioadenosine phosphorylase; Short=MTA phosphorylase; Short=MTAP; Short=MTAPase [Aedes aegypti]>gi|108871452|gb|EAT35677.1| AAEL012172-PA [Aedes aegypti]>gi|108871453|gb|EAT35678.1| AAEL012179-PA [Aedes aegypti] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q16MW6 535 2.9e-53 S-methyl-5'-thioadenosine phosphorylase OS=Aedes aegypti GN=AAEL012172 PE=3 SV=1 PF12422//PF01048 Condensin II non structural maintenance of chromosomes subunit//Phosphorylase superfamily GO:0043094//GO:1901566//GO:0009116//GO:0044271 cellular metabolic compound salvage//organonitrogen compound biosynthetic process//nucleoside metabolic process//cellular nitrogen compound biosynthetic process GO:0003824//GO:0016763 catalytic activity//transferase activity, transferring pentosyl groups GO:0005634//GO:0044424 nucleus//intracellular part KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.21936 BF_2 67.00 9.44 584 91088177 XP_972343.1 426 1.5e-39 PREDICTED: nuclear nucleic acid-binding protein C1D [Tribolium castaneum]>gi|270012131|gb|EFA08579.1| hypothetical protein TcasGA2_TC006234 [Tribolium castaneum] -- -- -- -- -- K12592 C1D, LRP1 exosome complex protein LRP1 http://www.genome.jp/dbget-bin/www_bget?ko:K12592 Q3KPR1 180 2.1e-12 Nuclear nucleic acid-binding protein C1D OS=Xenopus laevis GN=c1d PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21937 BF_2 38.92 1.19 1660 642915229 XP_008190531.1 1140 7.0e-122 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 676 1.8e-69 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.21938 BF_2 42.14 1.36 1588 642915229 XP_008190531.1 2008 1.5e-222 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 1135 1.0e-122 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.21940 BF_2 22.91 0.54 2073 642916810 XP_967695.2 1375 4.9e-149 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 985 3.4e-105 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0005515//GO:0042301 protein binding//phosphate ion binding GO:0009523//GO:0016020 photosystem II//membrane KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.21941 BF_2 7.00 1.89 442 821023330 XP_012358842.1 315 8.5e-27 PREDICTED: guanine nucleotide-binding protein subunit alpha-11 [Nomascus leucogenys] 583828549 NG_033852.2 335 1.11618e-173 Homo sapiens guanine nucleotide binding protein (G protein), alpha 11 (Gq class) (GNA11), RefSeqGene on chromosome 19 K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P38409 285 1.0e-24 Guanine nucleotide-binding protein subunit alpha-11 OS=Bos taurus GN=GNA11 PE=2 SV=2 PF00503 G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0019001//GO:0004871//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.21942 BF_2 416.00 194.93 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07174 Fibronectin-attachment protein (FAP) -- -- GO:0050840 extracellular matrix binding GO:0005576 extracellular region -- -- Cluster-8309.21943 BF_2 38.13 3.26 777 634006997 AHZ59669.1 398 3.6e-36 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 289 6.4e-25 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21944 BF_2 65.00 3.22 1132 642924471 XP_972019.2 684 3.6e-69 PREDICTED: SOX domain-containing protein dichaete [Tribolium castaneum] 572297918 XM_006615069.1 90 4.69057e-37 PREDICTED: Apis dorsata transcription factor Sox-21-B-like (LOC102672887), mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q24533 425 1.6e-40 SOX domain-containing protein dichaete OS=Drosophila melanogaster GN=D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.21949 BF_2 1.00 10.93 231 570341982 AHE77387.1 176 5.9e-11 heat shock protein 70, partial [Lissorhoptrus oryzophilus] 215254405 FJ177313.1 60 4.04256e-21 Aedes aegypti heat shock 70 Ca (Hsp70Ca) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 161 1.3e-10 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.2195 BF_2 17.00 0.34 2366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21950 BF_2 40.64 0.34 5251 642918446 XP_008191478.1 2992 0.0e+00 PREDICTED: protein zer-1 homolog [Tribolium castaneum]>gi|270003243|gb|EEZ99690.1| hypothetical protein TcasGA2_TC002447 [Tribolium castaneum] 749792139 XM_011150998.1 183 4.45851e-88 PREDICTED: Harpegnathos saltator cytochrome P450 6k1-like (LOC105189108), transcript variant X7, mRNA K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9W0E8 1706 2.1e-188 Protein zer-1 homolog OS=Drosophila melanogaster GN=CG12084 PE=2 SV=2 PF00514//PF13855//PF00560 Armadillo/beta-catenin-like repeat//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG4567 GTPase-activating protein Cluster-8309.21951 BF_2 64.00 7.54 642 646720800 KDR22397.1 603 5.0e-60 MORN repeat-containing protein 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q0VD26 376 4.3e-35 MORN repeat-containing protein 4 OS=Bos taurus GN=MORN4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.21952 BF_2 57.93 0.72 3676 642917889 XP_008191371.1 1627 5.2e-178 PREDICTED: regulator of chromosome condensation [Tribolium castaneum]>gi|642917891|ref|XP_008191372.1| PREDICTED: regulator of chromosome condensation [Tribolium castaneum] -- -- -- -- -- K11493 RCC1 regulator of chromosome condensation http://www.genome.jp/dbget-bin/www_bget?ko:K11493 P25183 890 6.2e-94 Regulator of chromosome condensation OS=Xenopus laevis GN=rcc1 PE=2 SV=1 PF03989//PF01405 DNA gyrase C-terminal domain, beta-propeller//Photosystem II reaction centre T protein GO:0006265//GO:0015979 DNA topological change//photosynthesis GO:0003677//GO:0005524//GO:0003916 DNA binding//ATP binding//DNA topoisomerase activity GO:0005694//GO:0016020//GO:0009539//GO:0009523 chromosome//membrane//photosystem II reaction center//photosystem II KOG1426 FOG: RCC1 domain Cluster-8309.21953 BF_2 368.00 5.81 2939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21954 BF_2 5.00 1.51 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21955 BF_2 401.00 4.35 4147 91085441 XP_969050.1 1854 2.8e-204 PREDICTED: wee1-like protein kinase [Tribolium castaneum] -- -- -- -- -- K06632 WEE1 wee1-like protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06632 P47810 1142 4.2e-123 Wee1-like protein kinase OS=Mus musculus GN=Wee1 PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0601 Cyclin-dependent kinase WEE1 Cluster-8309.21956 BF_2 3.00 0.86 432 642925809 XP_969782.3 149 1.5e-07 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21957 BF_2 105.00 3.18 1670 478252830 ENN73219.1 164 1.0e-08 hypothetical protein YQE_10116, partial [Dendroctonus ponderosae]>gi|546672035|gb|ERL84091.1| hypothetical protein D910_01428 [Dendroctonus ponderosae]>gi|546672044|gb|ERL84097.1| hypothetical protein D910_01434 [Dendroctonus ponderosae]>gi|546672161|gb|ERL84154.1| hypothetical protein D910_01520 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02059//PF07548 Interleukin-3//Chlamydia polymorphic membrane protein middle domain GO:0006955//GO:0008283//GO:0040007//GO:0007165 immune response//cell proliferation//growth//signal transduction GO:0005135//GO:0008083 interleukin-3 receptor binding//growth factor activity GO:0005894//GO:0005576//GO:0019867 interleukin-3 receptor complex//extracellular region//outer membrane -- -- Cluster-8309.21964 BF_2 8.00 1.60 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09182 Bacterial purine repressor, N-terminal GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.21965 BF_2 647.40 8.60 3438 297595480 ADI48181.1 2154 3.8e-239 membrane alanyl aminopeptidase 1 [Chrysomela tremula] 826418381 XM_012668567.1 35 5.45025e-06 PREDICTED: Monomorium pharaonis uncharacterized LOC105829585 (LOC105829585), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 Q11001 1194 3.2e-129 Membrane alanyl aminopeptidase (Fragment) OS=Manduca sexta PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.21966 BF_2 38.00 2.73 870 642910796 XP_008193415.1 564 2.3e-55 PREDICTED: homeobox protein ceh-31-like [Tribolium castaneum]>gi|270015153|gb|EFA11601.1| nk homeobox 7 [Tribolium castaneum] 780130236 XM_780913.4 57 7.89638e-19 PREDICTED: Strongylocentrotus purpuratus homeobox protein GBX-2 (LOC580883), mRNA -- -- -- -- P56407 222 4.2e-17 Homeobox protein ceh-9 OS=Caenorhabditis elegans GN=ceh-9 PE=3 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0485 Transcription factor NKX-5.1/HMX1, contains HOX domain Cluster-8309.21967 BF_2 40.00 1.81 1212 642910796 XP_008193415.1 352 1.2e-30 PREDICTED: homeobox protein ceh-31-like [Tribolium castaneum]>gi|270015153|gb|EFA11601.1| nk homeobox 7 [Tribolium castaneum] 831526486 XM_012863970.1 44 1.87293e-11 PREDICTED: Fundulus heteroclitus NK1 homeobox 2 (nkx1-2), mRNA -- -- -- -- -- -- -- -- PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.21969 BF_2 283.36 9.38 1551 91079957 XP_969398.1 796 5.0e-82 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2197 BF_2 57.02 1.27 2171 270001382 EEZ97829.1 1663 2.1e-182 hypothetical protein TcasGA2_TC000197 [Tribolium castaneum] -- -- -- -- -- K01217 IDUA L-iduronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01217 P48441 943 2.6e-100 Alpha-L-iduronidase OS=Mus musculus GN=Idua PE=1 SV=2 PF01229 Glycosyl hydrolases family 39 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.21970 BF_2 58.62 0.61 4331 642911734 XP_008200718.1 1162 5.1e-124 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC660336 [Tribolium castaneum] 462310927 APGK01047154.1 60 8.71408e-20 Dendroctonus ponderosae Seq01047164, whole genome shotgun sequence -- -- -- -- Q6PD21 334 2.2e-29 SH2 domain-containing adapter protein B OS=Mus musculus GN=Shb PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.21971 BF_2 91.20 34.02 398 530723033 AGT42325.1 611 3.6e-61 skeletal muscle actin 2 [Portunus trituberculatus] 514833854 KC795683.1 362 0 Scylla paramamosain beta-actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P53474 602 1.7e-61 Actin, cytoskeletal 3A OS=Strongylocentrotus purpuratus GN=CYIIIA PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.21973 BF_2 411.84 9.02 2198 642916176 XP_008190917.1 2385 4.0e-266 PREDICTED: transcription factor 25 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BQ70 1132 3.2e-122 Transcription factor 25 OS=Homo sapiens GN=TCF25 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2422 Uncharacterized conserved protein Cluster-8309.21978 BF_2 5.50 0.39 875 665790563 XP_008560974.1 175 2.9e-10 PREDICTED: pro-resilin [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21981 BF_2 21.68 1.24 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.21988 BF_2 23.00 26.91 310 166947671 ABZ04122.1 315 6.0e-27 putative cuticle protein CP5 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F3 258 1.0e-21 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.21989 BF_2 56.10 1.05 2517 270012119 EFA08567.1 489 3.2e-46 hypothetical protein TcasGA2_TC006222 [Tribolium castaneum] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 193 2.8e-13 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.21990 BF_2 1249.05 23.08 2551 270012119 EFA08567.1 489 3.3e-46 hypothetical protein TcasGA2_TC006222 [Tribolium castaneum] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 193 2.8e-13 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.21993 BF_2 191.45 0.69 11926 546676183 ERL87250.1 7761 0.0e+00 hypothetical protein D910_04647 [Dendroctonus ponderosae] -- -- -- -- -- K19526 VPS13B vacuolar protein sorting-associated protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K19526 Q7Z7G8 952 1.3e-100 Vacuolar protein sorting-associated protein 13B OS=Homo sapiens GN=VPS13B PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.21994 BF_2 32.16 1.40 1248 546676123 ERL87190.1 674 5.7e-68 hypothetical protein D910_04590 [Dendroctonus ponderosae] -- -- -- -- -- K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 A8XI75 460 1.5e-44 Probable histone-lysine N-methyltransferase set-23 OS=Caenorhabditis briggsae GN=set-23 PE=3 SV=1 PF03871//PF00856//PF05033 RNA polymerase Rpb5, N-terminal domain//SET domain//Pre-SET motif GO:0006351//GO:0006144//GO:0034968//GO:0006479//GO:0006206//GO:0006554 transcription, DNA-templated//purine nucleobase metabolic process//histone lysine methylation//protein methylation//pyrimidine nucleobase metabolic process//lysine catabolic process GO:0003899//GO:0003677//GO:0018024//GO:0005515//GO:0008270 DNA-directed RNA polymerase activity//DNA binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding GO:0005634//GO:0005730 nucleus//nucleolus KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing Cluster-8309.21996 BF_2 181.08 3.11 2722 766938860 XP_011501956.1 794 1.5e-81 PREDICTED: uncharacterized protein LOC105365477 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF03505 Sulfatase//Clostridium enterotoxin GO:0008152//GO:0009405 metabolic process//pathogenesis GO:0008484 sulfuric ester hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.21998 BF_2 52.76 0.39 5997 675383848 KFM76745.1 5518 0.0e+00 Myosin heavy chain, muscle, partial [Stegodyphus mimosarum] 241997621 XM_002433415.1 990 0 Ixodes scapularis myosin heavy chain, skeletal muscle or cardiac muscle, putative, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 5017 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00612//PF09728//PF00063//PF01576//PF00769//PF00038 IQ calmodulin-binding motif//Myosin-like coiled-coil protein//Myosin head (motor domain)//Myosin tail//Ezrin/radixin/moesin family//Intermediate filament protein -- -- GO:0019905//GO:0005198//GO:0005515//GO:0005524//GO:0008092//GO:0003774 syntaxin binding//structural molecule activity//protein binding//ATP binding//cytoskeletal protein binding//motor activity GO:0005882//GO:0019898//GO:0016459//GO:0005737 intermediate filament//extrinsic component of membrane//myosin complex//cytoplasm -- -- Cluster-8309.21999 BF_2 655.56 7.24 4075 478261443 ENN80813.1 1898 2.2e-209 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 140 2.76552e-64 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 1081 4.9e-116 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.22002 BF_2 99.82 2.09 2283 478259695 ENN79539.1 904 2.2e-94 hypothetical protein YQE_04002, partial [Dendroctonus ponderosae]>gi|546679825|gb|ERL90217.1| hypothetical protein D910_07570 [Dendroctonus ponderosae] -- -- -- -- -- K05995 pepE dipeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K05995 Q91642 697 9.2e-72 Alpha-aspartyl dipeptidase OS=Xenopus laevis GN=aad-a PE=1 SV=1 PF03575 Peptidase family S51 GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- -- -- Cluster-8309.22005 BF_2 256.41 10.36 1322 270011004 EFA07452.1 1004 3.3e-106 serine protease P91 [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P13582 498 6.3e-49 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.22007 BF_2 9.00 0.44 1135 861627520 KMQ89105.1 1139 6.2e-122 pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P0CT40 326 4.8e-29 Transposon Tf2-9 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-9 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.22015 BF_2 578.26 13.53 2075 571330974 AHF27419.1 1176 5.8e-126 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A5LGM7 634 1.7e-64 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.22016 BF_2 183.00 6.72 1427 270011401 EFA07849.1 710 4.3e-72 hypothetical protein TcasGA2_TC005419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22017 BF_2 40.16 0.73 2603 91081127 XP_976484.1 546 8.2e-53 PREDICTED: protein maelstrom [Tribolium castaneum]>gi|270006444|gb|EFA02892.1| maelstrom [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0W2W6 332 2.2e-29 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.22019 BF_2 8.00 0.86 677 1359436 BAA04557.1 606 2.4e-60 Mag44 [Dermatophagoides farinae] 2660867 AF034954.1 155 2.02085e-73 AF034954 Homarus americanus fast tropomyosin isoform (fTm) mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q23939 606 9.7e-62 Tropomyosin OS=Dermatophagoides farinae PE=1 SV=2 PF06009//PF05531//PF07167//PF04048//PF06008//PF01920//PF05739//PF10473//PF15964//PF02185//PF05557//PF04513//PF08702//PF15898 Laminin Domain II//Nucleopolyhedrovirus P10 protein//Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus//Sec8 exocyst complex component specific domain//Laminin Domain I//Prefoldin subunit//SNARE domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomal colon cancer autoantigen protein family//Hr1 repeat//Mitotic checkpoint protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//cGMP-dependent protein kinase interacting domain GO:0015031//GO:0045995//GO:0030334//GO:0007165//GO:0051258//GO:0030168//GO:0007094//GO:0007155//GO:0030155//GO:0042619//GO:0006457//GO:0006904//GO:0051297 protein transport//regulation of embryonic development//regulation of cell migration//signal transduction//protein polymerization//platelet activation//mitotic spindle assembly checkpoint//cell adhesion//regulation of cell adhesion//poly-hydroxybutyrate biosynthetic process//protein folding//vesicle docking involved in exocytosis//centrosome organization GO:0019901//GO:0005102//GO:0051082//GO:0045502//GO:0008134//GO:0005198//GO:0042803//GO:0030674//GO:0005515 protein kinase binding//receptor binding//unfolded protein binding//dynein binding//transcription factor binding//structural molecule activity//protein homodimerization activity//protein binding, bridging//protein binding GO:0016272//GO:0005577//GO:0019028//GO:0000145//GO:0005813//GO:0030286//GO:0005667//GO:0019031 prefoldin complex//fibrinogen complex//viral capsid//exocyst//centrosome//dynein complex//transcription factor complex//viral envelope KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.22020 BF_2 112.83 2.07 2572 478252154 ENN72582.1 1192 1.0e-127 hypothetical protein YQE_10683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01930 FPGS folylpolyglutamate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01930 P48760 845 7.1e-89 Folylpolyglutamate synthase, mitochondrial OS=Mus musculus GN=Fpgs PE=1 SV=3 PF02875//PF08245 Mur ligase family, glutamate ligase domain//Mur ligase middle domain GO:0009058 biosynthetic process GO:0005524//GO:0016874 ATP binding//ligase activity -- -- KOG2525 Folylpolyglutamate synthase Cluster-8309.22021 BF_2 4.00 0.41 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22024 BF_2 70.00 7.04 703 478259043 ENN78986.1 629 5.3e-63 hypothetical protein YQE_04537, partial [Dendroctonus ponderosae]>gi|478266116|gb|ENN82691.1| hypothetical protein YQE_00938, partial [Dendroctonus ponderosae]>gi|546678356|gb|ERL88989.1| hypothetical protein D910_06367 [Dendroctonus ponderosae] -- -- -- -- -- K13152 ZMAT5 U11/U12 small nuclear ribonucleoprotein 20 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13152 Q9CQR5 265 3.5e-22 Zinc finger matrin-type protein 5 OS=Mus musculus GN=Zmat5 PE=2 SV=1 PF00642//PF06220 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//U1 zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.22028 BF_2 105.34 1.23 3857 642938177 XP_008191025.1 440 2.4e-40 PREDICTED: G-protein coupled receptor Mth2-like isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXD9 174 6.9e-11 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF03595//PF00001//PF00002 Voltage-dependent anion channel//7 transmembrane receptor (rhodopsin family)//7 transmembrane receptor (Secretin family) GO:0007186//GO:0055085 G-protein coupled receptor signaling pathway//transmembrane transport GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22031 BF_2 29.76 2.04 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13958 Toxin ToxN, type III toxin-antitoxin system GO:0051252 regulation of RNA metabolic process GO:0004521//GO:0003723 endoribonuclease activity//RNA binding -- -- -- -- Cluster-8309.22033 BF_2 41.34 1.15 1795 91087191 XP_975444.1 735 6.9e-75 PREDICTED: SAGA-associated factor 29 homolog [Tribolium castaneum]>gi|270009566|gb|EFA06014.1| hypothetical protein TcasGA2_TC008842 [Tribolium castaneum] -- -- -- -- -- K11364 SGF29 SAGA-associated factor 29 http://www.genome.jp/dbget-bin/www_bget?ko:K11364 Q9DA08 461 1.7e-44 SAGA-associated factor 29 homolog OS=Mus musculus GN=Ccdc101 PE=2 SV=1 PF11744//PF08702//PF00631 Aluminium activated malate transporter//Fibrinogen alpha/beta chain family//GGL domain GO:0030168//GO:0007186//GO:0007165//GO:0051258//GO:0015743 platelet activation//G-protein coupled receptor signaling pathway//signal transduction//protein polymerization//malate transport GO:0005102//GO:0004871//GO:0030674 receptor binding//signal transducer activity//protein binding, bridging GO:0005577//GO:0005834 fibrinogen complex//heterotrimeric G-protein complex KOG3038 Histone acetyltransferase SAGA associated factor SGF29 Cluster-8309.22034 BF_2 11.00 13.91 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22036 BF_2 157.00 3.59 2117 642938754 XP_008199874.1 1325 3.1e-143 PREDICTED: somatostatin-like receptor F_48D10.1 [Tribolium castaneum]>gi|270015914|gb|EFA12362.1| hypothetical protein TcasGA2_TC002068 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDN6 189 6.9e-13 Neuropeptide Y receptor type 2 OS=Gallus gallus GN=NPY2R PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22037 BF_2 2.00 1.88 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22039 BF_2 11.35 0.67 992 91093871 XP_967859.1 438 1.0e-40 PREDICTED: OTU domain-containing protein 5-A [Tribolium castaneum]>gi|270014527|gb|EFA10975.1| hypothetical protein TcasGA2_TC004141 [Tribolium castaneum] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q08BW0 151 8.2e-09 OTU domain-containing protein 5-A OS=Danio rerio GN=otud5a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.22042 BF_2 1.00 0.39 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22044 BF_2 72.10 1.36 2507 91085445 XP_966423.1 602 2.5e-59 PREDICTED: peptidyl-tRNA hydrolase 2, mitochondrial [Tribolium castaneum]>gi|270009178|gb|EFA05626.1| hypothetical protein TcasGA2_TC015834 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 Q3ZBL5 274 1.1e-22 Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus GN=PTRH2 PE=2 SV=1 PF09243//PF01981//PF04434 Mitochondrial small ribosomal subunit Rsm22//Peptidyl-tRNA hydrolase PTH2//SWIM zinc finger GO:0006412 translation GO:0008168//GO:0008270//GO:0004045 methyltransferase activity//zinc ion binding//aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.22045 BF_2 67.00 7.23 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22047 BF_2 102.00 2.30 2141 91085745 XP_973735.1 1721 3.8e-189 PREDICTED: rabenosyn-5 [Tribolium castaneum]>gi|270010009|gb|EFA06457.1| hypothetical protein TcasGA2_TC009340 [Tribolium castaneum] -- -- -- -- -- K12481 ZFYVE20 rabenosyn-5 http://www.genome.jp/dbget-bin/www_bget?ko:K12481 Q80Y56 471 1.4e-45 Rabenosyn-5 OS=Mus musculus GN=Rbsn PE=2 SV=1 PF00096//PF06657//PF01363 Zinc finger, C2H2 type//Centrosome microtubule-binding domain of Cep57//FYVE zinc finger -- -- GO:0008017//GO:0008270//GO:0046872 microtubule binding//zinc ion binding//metal ion binding GO:0005622//GO:0045298 intracellular//tubulin complex KOG1842 FYVE finger-containing protein Cluster-8309.22048 BF_2 89.00 0.91 4384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22049 BF_2 231.14 2.32 4446 270005465 EFA01913.1 5364 0.0e+00 hypothetical protein TcasGA2_TC007523 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UGF1 3335 0.0e+00 WD repeat-containing protein 19 OS=Mus musculus GN=Wdr19 PE=1 SV=1 PF13181//PF06209//PF00637//PF13414 Tetratricopeptide repeat//Cofactor of BRCA1 (COBRA1)//Region in Clathrin and VPS//TPR repeat GO:0016192//GO:0006886//GO:0045892 vesicle-mediated transport//intracellular protein transport//negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG2247 WD40 repeat-containing protein Cluster-8309.22051 BF_2 601.50 2.84 9142 642929789 XP_008195977.1 2705 1.3e-302 PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Tribolium castaneum] 118150627 NM_001077805.1 77 6.54868e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1707 2.8e-188 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF05093//PF01421//PF10462//PF00413//PF01562 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Reprolysin (M12B) family zinc metalloprotease//Peptidase M66//Matrixin//Reprolysin family propeptide GO:0016226//GO:0006508 iron-sulfur cluster assembly//proteolysis GO:0051536//GO:0008270//GO:0004222 iron-sulfur cluster binding//zinc ion binding//metalloendopeptidase activity GO:0031012//GO:0005737 extracellular matrix//cytoplasm KOG2210 Oxysterol-binding protein Cluster-8309.22052 BF_2 14.00 0.35 1974 642935043 XP_969003.2 1260 1.0e-135 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [Tribolium castaneum] -- -- -- -- -- K12670 WBP1 oligosaccharyltransferase complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12670 Q24319 973 7.9e-104 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Drosophila melanogaster GN=Ost48 PE=2 SV=2 PF03345 Oligosaccharyltransferase 48 kDa subunit beta GO:0018279 protein N-linked glycosylation via asparagine -- -- GO:0005789 endoplasmic reticulum membrane KOG2754 Oligosaccharyltransferase, beta subunit Cluster-8309.22055 BF_2 32.88 0.97 1701 817202705 XP_012277149.1 284 1.3e-22 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Orussus abietinus] -- -- -- -- -- K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 219 1.8e-16 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.22058 BF_2 23.24 0.92 1345 91092208 XP_969730.1 1137 1.3e-121 PREDICTED: protein unc-50 homolog [Tribolium castaneum]>gi|270014482|gb|EFA10930.1| hypothetical protein TcasGA2_TC001757 [Tribolium castaneum] 602644740 XM_007428757.1 49 3.46364e-14 PREDICTED: Python bivittatus unc-50 homolog (C. elegans) (UNC50), transcript variant X5, mRNA -- -- -- -- Q9VHN5 860 6.8e-91 Protein unc-50 homolog OS=Drosophila melanogaster GN=CG9773 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3012 Uncharacterized conserved protein Cluster-8309.22062 BF_2 305.00 10.43 1510 642935173 XP_008199677.1 637 1.3e-63 PREDICTED: elongation of very long chain fatty acids protein 7 [Tribolium castaneum]>gi|270014194|gb|EFA10642.1| hypothetical protein TcasGA2_TC016279 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 A0JNC4 444 1.3e-42 Elongation of very long chain fatty acids protein 7 OS=Bos taurus GN=ELOVL7 PE=2 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22063 BF_2 183.65 11.86 935 642936428 XP_008198430.1 990 9.7e-105 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462294748 APGK01052997.1 59 6.57889e-20 Dendroctonus ponderosae Seq01053007, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 320 2.0e-28 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22067 BF_2 169.23 1.95 3919 91092536 XP_967769.1 2382 1.6e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.6e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004674//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.22068 BF_2 6.50 0.77 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22069 BF_2 25.45 0.44 2703 642931541 XP_008196629.1 2039 6.4e-226 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 O75460 1229 2.2e-133 Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2 PF06293//PF00069//PF07714//PF00804//PF06479 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Syntaxin//Ribonuclease 2-5A GO:0006468//GO:0006397//GO:0051252 protein phosphorylation//mRNA processing//regulation of RNA metabolic process GO:0004540//GO:0005524//GO:0004672//GO:0016772//GO:0016773 ribonuclease activity//ATP binding//protein kinase activity//transferase activity, transferring phosphorus-containing groups//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.22070 BF_2 2.00 1.53 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22074 BF_2 25.06 2.42 721 642914007 XP_008201509.1 611 6.6e-61 PREDICTED: uncharacterized protein LOC103315204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22077 BF_2 74.68 0.47 6928 102939 1510 3.6e-164 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1178 4.7e-127 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03310//PF04137//PF02966//PF00665//PF13683 Caulimovirus DNA-binding protein//Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//Mitosis protein DIM1//Integrase core domain//Integrase core domain GO:0015074//GO:0000398//GO:0055114 DNA integration//mRNA splicing, via spliceosome//oxidation-reduction process GO:0016671//GO:0003677//GO:0003756 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//DNA binding//protein disulfide isomerase activity GO:0005783//GO:0005681 endoplasmic reticulum//spliceosomal complex -- -- Cluster-8309.22078 BF_2 154.33 5.12 1548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2208 BF_2 2.00 4.66 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22081 BF_2 143.37 3.85 1845 546673262 ERL84900.1 835 1.8e-86 hypothetical protein D910_02323 [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 622 3.7e-63 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF09238//PF00287 Interleukin-4 receptor alpha chain, N-terminal//Sodium / potassium ATPase beta chain GO:0006813//GO:0007165//GO:0006814//GO:0002532 potassium ion transport//signal transduction//sodium ion transport//production of molecular mediator involved in inflammatory response GO:0004896 cytokine receptor activity GO:0016021//GO:0005890 integral component of membrane//sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.22087 BF_2 4.00 2.14 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22088 BF_2 233.18 6.51 1786 270011137 EFA07585.1 462 3.1e-43 ion transport peptide [Tribolium castaneum] 746837167 XM_011071011.1 88 9.67312e-36 PREDICTED: Acromyrmex echinatior ion transport peptide-like (LOC105155100), transcript variant X3, mRNA -- -- -- -- Q26492 414 4.7e-39 Ion transport peptide-like OS=Schistocerca gregaria PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22090 BF_2 39.00 11.22 432 642924686 XP_008194398.1 242 2.4e-18 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22091 BF_2 63.20 1.27 2371 642924686 XP_008194398.1 2209 1.1e-245 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 737 2.2e-76 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF07086//PF00999 Jagunal, ER re-organisation during oogenesis//Sodium/hydrogen exchanger family GO:0006885//GO:0055085//GO:0006812//GO:0007029 regulation of pH//transmembrane transport//cation transport//endoplasmic reticulum organization GO:0015299 solute:proton antiporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3826 Na+/H+ antiporter Cluster-8309.22092 BF_2 355.00 10.05 1765 642934073 XP_008196077.1 288 4.6e-23 PREDICTED: tetraspanin-33-like [Tribolium castaneum]>gi|270012946|gb|EFA09394.1| hypothetical protein TcasGA2_TC004312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00822//PF01529//PF13903//PF00335//PF04505//PF07690//PF02076 PMP-22/EMP/MP20/Claudin family//DHHC palmitoyltransferase//PMP-22/EMP/MP20/Claudin tight junction//Tetraspanin family//Interferon-induced transmembrane protein//Major Facilitator Superfamily//Pheromone A receptor GO:0055085//GO:0007606//GO:0019236//GO:0007186//GO:0009607 transmembrane transport//sensory perception of chemical stimulus//response to pheromone//G-protein coupled receptor signaling pathway//response to biotic stimulus GO:0004932//GO:0008270 mating-type factor pheromone receptor activity//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.22093 BF_2 33.00 0.78 2062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22094 BF_2 1.00 20.55 216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22097 BF_2 68.37 6.75 711 91077456 XP_967801.1 688 7.7e-70 PREDICTED: sine oculis-binding protein homolog [Tribolium castaneum]>gi|270002754|gb|EEZ99201.1| sine oculis-binding protein [Tribolium castaneum] 768434667 XM_011560449.1 71 1.055e-26 PREDICTED: Plutella xylostella sine oculis-binding protein homolog (LOC105389350), partial mRNA -- -- -- -- Q0P5V2 260 1.4e-21 Sine oculis-binding protein homolog OS=Mus musculus GN=Sobp PE=2 SV=1 PF03884//PF06467//PF02069 Domain of unknown function (DUF329)//MYM-type Zinc finger with FCS sequence motif//Prokaryotic metallothionein -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.22098 BF_2 73.00 4.57 955 91077456 XP_967801.1 286 4.3e-23 PREDICTED: sine oculis-binding protein homolog [Tribolium castaneum]>gi|270002754|gb|EEZ99201.1| sine oculis-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22100 BF_2 53.85 0.91 2758 642912892 XP_008201299.1 802 1.8e-82 PREDICTED: uncharacterized protein LOC660220 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22102 BF_2 42.00 0.76 2605 642910817 XP_008193421.1 1210 8.3e-130 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 1.0e-26 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22103 BF_2 12.00 1.40 645 83658844 ABC40572.1 138 4.2e-06 putative antimicrobial knottin protein Btk-4 [Bemisia tabaci] -- -- -- -- -- -- -- -- -- P83653 146 2.0e-08 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22106 BF_2 160.23 6.35 1342 332375520 AEE62901.1 477 4.3e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7ZVE6 368 7.6e-34 KDEL motif-containing protein 1 OS=Danio rerio GN=kdelc1 PE=2 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.22107 BF_2 99.66 1.85 2537 91081993 XP_969039.1 1700 1.2e-186 PREDICTED: KDEL motif-containing protein 1 [Tribolium castaneum]>gi|270007375|gb|EFA03823.1| hypothetical protein TcasGA2_TC013938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UW63 1169 1.9e-126 KDEL motif-containing protein 1 OS=Homo sapiens GN=KDELC1 PE=1 SV=1 PF05353 Delta Atracotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG4479 Transcription factor e(y)2 Cluster-8309.22108 BF_2 70.00 1.28 2580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22110 BF_2 5.00 0.45 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22111 BF_2 415.85 57.06 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22112 BF_2 11.06 1.19 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22114 BF_2 96.83 0.69 6145 642929679 XP_975498.3 2932 0.0e+00 PREDICTED: metastasis-associated protein MTA3 isoform X2 [Tribolium castaneum] 768415855 XM_011550194.1 183 5.22282e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1635 4.2e-180 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF00320//PF00096//PF01426 GATA zinc finger//Zinc finger, C2H2 type//BAH domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003682//GO:0003700//GO:0043565//GO:0008270 metal ion binding//chromatin binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0000785 transcription factor complex//chromatin KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.22116 BF_2 402.00 10.15 1944 642913803 XP_008201165.1 1411 3.1e-153 PREDICTED: alpha-2-macroglobulin receptor-associated protein [Tribolium castaneum]>gi|270002092|gb|EEZ98539.1| hypothetical protein TcasGA2_TC001043 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55302 405 5.7e-38 Alpha-2-macroglobulin receptor-associated protein OS=Mus musculus GN=Lrpap1 PE=1 SV=1 PF06401 Alpha-2-macroglobulin RAP, C-terminal domain GO:0007165 signal transduction GO:0008201//GO:0050750 heparin binding//low-density lipoprotein particle receptor binding GO:0005783 endoplasmic reticulum KOG3956 Alpha 2-macroglobulin receptor-associated protein Cluster-8309.22117 BF_2 356.06 7.61 2244 91078954 XP_974170.1 2607 7.3e-292 PREDICTED: negative elongation factor B [Tribolium castaneum]>gi|270004158|gb|EFA00606.1| hypothetical protein TcasGA2_TC003481 [Tribolium castaneum] -- -- -- -- -- K15180 COBRA1, NELFB negative elongation factor B http://www.genome.jp/dbget-bin/www_bget?ko:K15180 Q9Y113 2185 2.6e-244 Negative elongation factor B OS=Drosophila melanogaster GN=NELF-B PE=1 SV=1 PF06209//PF04997 Cofactor of BRCA1 (COBRA1)//RNA polymerase Rpb1, domain 1 GO:0006206//GO:0045892//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//negative regulation of transcription, DNA-templated//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.22118 BF_2 1.00 5.13 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22121 BF_2 46.19 2.78 982 478258940 ENN78915.1 512 2.7e-49 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 P0DKC3 244 1.3e-19 Phosphoglycolate phosphatase 1A, chloroplastic OS=Arabidopsis thaliana GN=PGLP1A PE=1 SV=1 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.22122 BF_2 544.20 8.88 2850 642910918 XP_008193464.1 1440 1.9e-156 PREDICTED: microphthalmia-associated transcription factor isoform X2 [Tribolium castaneum] 195469444 XM_002099612.1 83 9.35304e-33 Drosophila yakuba GE14571 (Dyak\GE14571), partial mRNA K09455 MITF microphthalmia-associated transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09455 O75030 326 1.2e-28 Microphthalmia-associated transcription factor OS=Homo sapiens GN=MITF PE=1 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG1318 Helix loop helix transcription factor EB Cluster-8309.22123 BF_2 199.95 4.44 2172 820805546 AKG92764.1 1085 2.2e-115 mitf [Leptinotarsa decemlineata] 820805545 KP147927.1 274 4.73429e-139 Leptinotarsa decemlineata mitf mRNA, complete cds K09455 MITF microphthalmia-associated transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09455 O75030 326 9.2e-29 Microphthalmia-associated transcription factor OS=Homo sapiens GN=MITF PE=1 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG1318 Helix loop helix transcription factor EB Cluster-8309.22126 BF_2 68.00 1.55 2118 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22127 BF_2 84.06 0.78 4779 270013169 EFA09617.1 2675 2.0e-299 hypothetical protein TcasGA2_TC011738 [Tribolium castaneum] 195495540 XM_002095275.1 180 1.8866e-86 Drosophila yakuba GE19764 (Dyak\GE19764), partial mRNA K08819 CDK12_13 cyclin-dependent kinase 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K08819 Q9VP22 1822 6.8e-202 Cyclin-dependent kinase 12 OS=Drosophila melanogaster GN=Cdk12 PE=1 SV=1 PF07714//PF00876//PF04505//PF00069//PF08272 Protein tyrosine kinase//Innexin//Interferon-induced transmembrane protein//Protein kinase domain//Topoisomerase I zinc-ribbon-like GO:0009607//GO:0006265//GO:0006468 response to biotic stimulus//DNA topological change//protein phosphorylation GO:0003918//GO:0004672//GO:0005524//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//protein kinase activity//ATP binding//DNA binding GO:0005694//GO:0005921//GO:0016021 chromosome//gap junction//integral component of membrane KOG0600 Cdc2-related protein kinase Cluster-8309.22129 BF_2 135.99 1.91 3271 642910948 XP_008193477.1 3025 0.0e+00 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 2124 4.5e-237 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0070008 serine-type peptidase activity//serine-type endopeptidase activity//serine-type exopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.2213 BF_2 14.93 0.55 1417 861649849 KMQ97012.1 643 2.5e-64 Cuticlin-1 [Lasius niger] 817183960 XM_012423831.1 174 1.19029e-83 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22130 BF_2 12.68 0.42 1542 642910948 XP_008193477.1 306 3.3e-25 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 P23687 195 1.0e-13 Prolyl endopeptidase OS=Sus scrofa GN=PREP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2237 Predicted serine protease Cluster-8309.22131 BF_2 171.87 1.34 5670 642915666 XP_008190704.1 2006 9.1e-222 PREDICTED: adenylate cyclase type 2-like, partial [Tribolium castaneum] 769847817 XM_011636959.1 159 1.0575e-74 PREDICTED: Pogonomyrmex barbatus adenylate cyclase type 2 (LOC105425936), transcript variant X4, mRNA K08042 ADCY2 adenylate cyclase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08042 Q9VW60 1167 7.2e-126 Adenylate cyclase type 2 OS=Drosophila melanogaster GN=Ac76E PE=2 SV=3 PF00211//PF06327 Adenylate and Guanylate cyclase catalytic domain//Domain of Unknown Function (DUF1053) GO:0009190//GO:0006144//GO:0035556//GO:0006171 cyclic nucleotide biosynthetic process//purine nucleobase metabolic process//intracellular signal transduction//cAMP biosynthetic process GO:0004016//GO:0016849 adenylate cyclase activity//phosphorus-oxygen lyase activity GO:0005886 plasma membrane -- -- Cluster-8309.22133 BF_2 678.90 6.17 4889 270004843 EFA01291.1 3974 0.0e+00 cubitus interruptus [Tribolium castaneum] 170028989 XM_001842325.1 250 2.35967e-125 Culex quinquefasciatus cubitus interruptus, mRNA K16799 CI transcriptional activator cubitus interruptus http://www.genome.jp/dbget-bin/www_bget?ko:K16799 P19538 1162 2.4e-125 Transcriptional activator cubitus interruptus OS=Drosophila melanogaster GN=ci PE=1 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.22135 BF_2 27.00 1.27 1175 528515089 XP_005161614.1 575 1.6e-56 PREDICTED: zinc finger MYM-type protein 1-like [Danio rerio] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07462 Merozoite surface protein 1 (MSP1) C-terminus GO:0009405 pathogenesis -- -- GO:0016020 membrane -- -- Cluster-8309.22138 BF_2 137.07 1.31 4680 642910357 XP_008200291.1 5736 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase Genghis Khan [Tribolium castaneum] 642910356 XM_008202069.1 1045 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 2058 2.9e-229 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF01291//PF08826//PF00130//PF00069//PF00433//PF07714 LIF / OSM family//DMPK coiled coil domain like//Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0007165//GO:0016310//GO:0009069//GO:0006468//GO:0006955//GO:0035556 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//immune response//intracellular signal transduction GO:0005524//GO:0005125//GO:0004672//GO:0004674 ATP binding//cytokine activity//protein kinase activity//protein serine/threonine kinase activity GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.22139 BF_2 16.00 0.78 1148 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22140 BF_2 77.21 1.56 2359 642928571 XP_008199962.1 982 2.1e-103 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q7ZV22 906 5.5e-96 S-methyl-5'-thioadenosine phosphorylase OS=Danio rerio GN=mtap PE=2 SV=2 PF01048//PF09242 Phosphorylase superfamily//Flavocytochrome c sulphide dehydrogenase, flavin-binding GO:0009116//GO:0055114 nucleoside metabolic process//oxidation-reduction process GO:0003824//GO:0050660//GO:0016491 catalytic activity//flavin adenine dinucleotide binding//oxidoreductase activity -- -- KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.22141 BF_2 5.00 3.51 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22143 BF_2 329.46 8.25 1957 332376416 AEE63348.1 742 1.2e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 8.8e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.22146 BF_2 192.93 2.10 4139 642924140 XP_008194024.1 5579 0.0e+00 PREDICTED: neural-cadherin isoform X8 [Tribolium castaneum] 642924139 XM_008195802.1 1163 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X8, mRNA -- -- -- -- O15943 4793 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF00028//PF00868//PF03222 Cadherin domain//Transglutaminase family//Tryptophan/tyrosine permease family GO:0018149//GO:0007156//GO:0003333 peptide cross-linking//homophilic cell adhesion via plasma membrane adhesion molecules//amino acid transmembrane transport GO:0005509 calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.22151 BF_2 44.29 1.66 1404 642923755 XP_008193870.1 975 8.0e-103 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0044763//GO:0050794 single-organism cellular process//regulation of cellular process -- -- -- -- -- -- Cluster-8309.22155 BF_2 1.00 0.65 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22157 BF_2 11.31 0.47 1298 642913141 XP_008201410.1 706 1.1e-71 PREDICTED: C-5 sterol desaturase erg31-like [Tribolium castaneum] -- -- -- -- -- K00227 SC5DL, ERG3 delta7-sterol 5-desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K00227 -- -- -- -- PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- -- -- Cluster-8309.22159 BF_2 333.07 3.77 3980 642911874 XP_008199002.1 3056 0.0e+00 PREDICTED: WASH complex subunit 7 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1906 1.0e-211 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.22161 BF_2 248.71 2.19 5035 642911874 XP_008199002.1 3172 0.0e+00 PREDICTED: WASH complex subunit 7 [Tribolium castaneum] -- -- -- -- -- K18465 MRT43, SWIP WASH complex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18465 Q2M389 1913 2.0e-212 WASH complex subunit 7 OS=Homo sapiens GN=KIAA1033 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3578 Uncharacterized conserved protein Cluster-8309.22162 BF_2 313.28 31.44 704 270007760 EFA04208.1 192 2.5e-12 hypothetical protein TcasGA2_TC014457, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PH91 152 4.4e-09 Single-pass membrane and coiled-coil domain-containing protein 4 homolog OS=Anopheles gambiae GN=AGAP003534 PE=3 SV=3 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22163 BF_2 76.32 1.91 1956 642927014 XP_001810799.2 847 7.7e-88 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBA6 232 6.6e-18 Peroxisomal leader peptide-processing protease OS=Mus musculus GN=Tysnd1 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.22164 BF_2 228.17 1.10 8984 642922229 XP_008193071.1 1543 7.0e-168 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] 642922228 XM_008194849.1 161 1.2978e-75 PREDICTED: Tribolium castaneum thiamine transporter 2-like (LOC661148), mRNA K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 Q22931 693 1.1e-70 Folate-like transporter 3 OS=Caenorhabditis elegans GN=folt-3 PE=3 SV=3 PF01292//PF01770//PF13145//PF01384//PF00033//PF00639 Prokaryotic cytochrome b561//Reduced folate carrier//PPIC-type PPIASE domain//Phosphate transporter family//Cytochrome b/b6/petB//PPIC-type PPIASE domain GO:0022904//GO:0006817//GO:0006810//GO:0006118 respiratory electron transport chain//phosphate ion transport//transport//obsolete electron transport GO:0005542//GO:0016853//GO:0005315//GO:0009055//GO:0008518 folic acid binding//isomerase activity//inorganic phosphate transmembrane transporter activity//electron carrier activity//reduced folate carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.22166 BF_2 130.74 1.30 4499 537136524 ERE66571.1 267 3.2e-20 zinc finger protein [Cricetulus griseus] 642937107 XM_008200472.1 160 2.32912e-75 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 49-like (LOC660399), mRNA -- -- -- -- Q14590 249 1.6e-19 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF01428//PF00651//PF02892//PF13912//PF06689//PF13465//PF00096 AN1-like Zinc finger//BTB/POZ domain//BED zinc finger//C2H2-type zinc finger//ClpX C4-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0003677//GO:0046983//GO:0005515//GO:0046872 zinc ion binding//DNA binding//protein dimerization activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.22168 BF_2 61.67 4.40 873 642931814 XP_008196744.1 595 5.8e-59 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q9VG82 369 3.8e-34 Probable cytochrome P450 9f2 OS=Drosophila melanogaster GN=Cyp9f2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.22173 BF_2 21.10 0.56 1871 478262792 ENN81309.1 291 2.2e-23 hypothetical protein YQE_02277, partial [Dendroctonus ponderosae] -- -- -- -- -- K19403 MCPH1 microcephalin http://www.genome.jp/dbget-bin/www_bget?ko:K19403 Q7TT79 134 1.4e-06 Microcephalin OS=Mus musculus GN=Mcph1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22178 BF_2 46.20 1.22 1877 478252210 ENN72638.1 1453 4.0e-158 hypothetical protein YQE_10736, partial [Dendroctonus ponderosae] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 Q9VPH2 968 2.8e-103 DNA primase large subunit OS=Drosophila melanogaster GN=DNApol-alpha60 PE=1 SV=2 PF04104//PF00542 Eukaryotic and archaeal DNA primase, large subunit//Ribosomal protein L7/L12 C-terminal domain GO:0006351//GO:0006412//GO:0006269//GO:0042254 transcription, DNA-templated//translation//DNA replication, synthesis of RNA primer//ribosome biogenesis GO:0003896//GO:0003735 DNA primase activity//structural constituent of ribosome GO:0005657//GO:0005840//GO:0005730 replication fork//ribosome//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.22183 BF_2 70.41 1.65 2069 91081013 XP_975219.1 1786 1.1e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 1.3e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.22186 BF_2 13.89 0.58 1293 478252777 ENN73170.1 209 4.9e-14 hypothetical protein YQE_10225, partial [Dendroctonus ponderosae] 642918204 XM_008193188.1 274 2.78696e-139 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22187 BF_2 16.11 0.70 1253 478252777 ENN73170.1 199 6.8e-13 hypothetical protein YQE_10225, partial [Dendroctonus ponderosae] 642918204 XM_008193188.1 274 2.69835e-139 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22189 BF_2 2.52 0.43 533 642918203 XP_008191409.1 560 4.0e-55 PREDICTED: zinc finger homeobox protein 4 isoform X2 [Tribolium castaneum] 642918204 XM_008193188.1 134 7.40045e-62 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.22190 BF_2 289.07 1.33 9398 642918201 XP_008191408.1 10448 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918206 XM_008193189.1 795 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.2e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF00096//PF00046//PF04988//PF13912//PF01435//PF05920//PF13411 Zinc finger, C2H2 type//Homeobox domain//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger//Peptidase family M48//Homeobox KN domain//MerR HTH family regulatory protein GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0046872//GO:0004222//GO:0003677 metal ion binding//metalloendopeptidase activity//DNA binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.22191 BF_2 5.24 0.42 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22193 BF_2 19.00 0.78 1307 675386024 KFM78921.1 1737 3.3e-191 60S ribosomal protein L3, partial [Stegodyphus mimosarum] 194743867 XM_001954386.1 363 0 Drosophila ananassae GF16740 (Dana\GF16740), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 1653 7.4e-183 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297//PF05662 Ribosomal protein L3//Coiled stalk of trimeric autotransporter adhesin GO:0006412//GO:0042254//GO:0009405 translation//ribosome biogenesis//pathogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0019867//GO:0005840 intracellular//outer membrane//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.22196 BF_2 137.26 1.66 3753 642924897 XP_008194088.1 3358 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P25391 1391 5.1e-152 Laminin subunit alpha-1 OS=Homo sapiens GN=LAMA1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.22197 BF_2 437.00 7.26 2805 91088529 XP_972184.1 2981 0.0e+00 PREDICTED: general vesicular transport factor p115 isoform X1 [Tribolium castaneum]>gi|270012234|gb|EFA08682.1| hypothetical protein TcasGA2_TC006352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41541 1790 2.1e-198 General vesicular transport factor p115 OS=Bos taurus GN=USO1 PE=1 SV=1 PF06009//PF04977//PF04111//PF05531//PF04869//PF13851//PF00170//PF04871//PF01496//PF10473//PF17078//PF02601 Laminin Domain II//Septum formation initiator//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein//Uso1 / p115 like vesicle tethering protein, head region//Growth-arrest specific micro-tubule binding//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//V-type ATPase 116kDa subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SWI5-dependent HO expression protein 3//Exonuclease VII, large subunit GO:0006308//GO:0007155//GO:0048309//GO:0048280//GO:0015991//GO:0048870//GO:0051028//GO:0015031//GO:0015992//GO:0007049//GO:0006355//GO:0006886//GO:0006914 DNA catabolic process//cell adhesion//endoplasmic reticulum inheritance//vesicle fusion with Golgi apparatus//ATP hydrolysis coupled proton transport//cell motility//mRNA transport//protein transport//proton transport//cell cycle//regulation of transcription, DNA-templated//intracellular protein transport//autophagy GO:0042803//GO:0008855//GO:0003700//GO:0008565//GO:0015078//GO:0043565//GO:0045502//GO:0008134 protein homodimerization activity//exodeoxyribonuclease VII activity//transcription factor activity, sequence-specific DNA binding//protein transporter activity//hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//dynein binding//transcription factor binding GO:0033179//GO:0016020//GO:0000139//GO:0005667//GO:0030286//GO:0005737//GO:0009318//GO:0031514//GO:0019028 proton-transporting V-type ATPase, V0 domain//membrane//Golgi membrane//transcription factor complex//dynein complex//cytoplasm//exodeoxyribonuclease VII complex//motile cilium//viral capsid KOG0946 ER-Golgi vesicle-tethering protein p115 Cluster-8309.22198 BF_2 161.00 2.45 3033 546671902 ERL84010.1 1764 5.6e-194 hypothetical protein D910_01329 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1133 3.4e-122 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00884//PF01676//PF01663//PF00245//PF01035 Sulfatase//Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase//Alkaline phosphatase//6-O-methylguanine DNA methyltransferase, DNA binding domain GO:0008152//GO:0006281 metabolic process//DNA repair GO:0008484//GO:0003824//GO:0046872//GO:0016791 sulfuric ester hydrolase activity//catalytic activity//metal ion binding//phosphatase activity -- -- -- -- Cluster-8309.2220 BF_2 2.00 0.44 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22203 BF_2 9.00 0.39 1261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22204 BF_2 278.68 2.94 4253 546677720 ERL88511.1 1320 2.4e-142 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 3.95258e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 977 5.8e-104 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.22206 BF_2 21.40 0.40 2502 478252719 ENN73114.1 812 1.1e-83 hypothetical protein YQE_10255, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VU84 589 3.4e-59 Drebrin-like protein OS=Drosophila melanogaster GN=Abp1 PE=1 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG3655 Drebrins and related actin binding proteins Cluster-8309.22207 BF_2 247.72 6.36 1917 546673853 ERL85383.1 1190 1.3e-127 hypothetical protein D910_02803 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GM14 706 7.0e-73 Drebrin-like protein B OS=Xenopus laevis GN=dbnl-b PE=2 SV=1 PF00241//PF00957//PF14604//PF00018 Cofilin/tropomyosin-type actin-binding protein//Synaptobrevin//Variant SH3 domain//SH3 domain GO:0016192 vesicle-mediated transport GO:0003779//GO:0005515 actin binding//protein binding GO:0016021//GO:0005622 integral component of membrane//intracellular KOG3655 Drebrins and related actin binding proteins Cluster-8309.22209 BF_2 5.00 0.48 721 795049583 XP_011869597.1 414 4.6e-38 PREDICTED: poly(A) polymerase type 3 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 P25500 354 1.7e-32 Poly(A) polymerase alpha OS=Bos taurus GN=PAPOLA PE=1 SV=3 PF04928 Poly(A) polymerase central domain GO:0043631 RNA polyadenylation GO:0004652 polynucleotide adenylyltransferase activity -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.2221 BF_2 16.00 0.82 1103 594191368 AHL84105.1 953 2.2e-100 F0-ATP synthase b-chain [Litopenaeus vannamei] 67083944 DQ066270.1 55 1.30615e-17 Ixodes scapularis isolate is-all-clu620 putative ATP synthase-like protein mRNA, complete cds K02127 ATPeF0B, ATP5F1, ATP4 F-type H+-transporting ATPase subunit b http://www.genome.jp/dbget-bin/www_bget?ko:K02127 Q94516 655 3.3e-67 ATP synthase subunit b, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-b PE=2 SV=2 PF00610//PF05405 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015986//GO:0035556//GO:0015992 ATP synthesis coupled proton transport//intracellular signal transduction//proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3976 Mitochondrial F1F0-ATP synthase, subunit b/ATP4 Cluster-8309.22212 BF_2 229.61 2.38 4321 91095023 XP_970355.1 619 4.7e-61 PREDICTED: inhibin beta chain [Tribolium castaneum]>gi|270015436|gb|EFA11884.1| dawdle [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 O61643 219 4.7e-16 Inhibin beta chain OS=Drosophila melanogaster GN=Actbeta PE=2 SV=2 PF00688//PF00019 TGF-beta propeptide//Transforming growth factor beta like domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0005576 extracellular region -- -- Cluster-8309.22213 BF_2 223.56 12.41 1041 91095023 XP_970355.1 843 1.2e-87 PREDICTED: inhibin beta chain [Tribolium castaneum]>gi|270015436|gb|EFA11884.1| dawdle [Tribolium castaneum] -- -- -- -- -- K04667 INHB inhibin, beta http://www.genome.jp/dbget-bin/www_bget?ko:K04667 O61643 277 2.1e-23 Inhibin beta chain OS=Drosophila melanogaster GN=Actbeta PE=2 SV=2 PF00019 Transforming growth factor beta like domain GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0005576 extracellular region KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.22214 BF_2 4.00 0.69 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22216 BF_2 78.16 0.41 8190 91094517 XP_971992.1 691 4.0e-69 PREDICTED: protein TEX261 isoform X2 [Tribolium castaneum] 665817572 XM_008559342.1 66 7.63938e-23 PREDICTED: Microplitis demolitor iron-sulfur cluster assembly 1 homolog, mitochondrial (LOC103578320), partial mRNA K13628 iscA, ISCA1 iron-sulfur cluster assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K13628 Q4QRC6 514 5.5e-50 Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Danio rerio GN=isca1 PE=2 SV=1 PF07882//PF12317 L-fucose isomerase, second N-terminal domain//Intraflagellar transport complex B protein 46 C terminal GO:0006013//GO:0006000//GO:0042073//GO:0006004 mannose metabolic process//fructose metabolic process//intraciliary transport//fucose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm KOG1120 Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) Cluster-8309.22217 BF_2 171.28 4.63 1836 270008020 EFA04468.1 1274 2.2e-137 hypothetical protein TcasGA2_TC014772 [Tribolium castaneum] 195493568 XM_002094438.1 148 4.40533e-69 Drosophila yakuba GE20183 (Dyak\GE20183), partial mRNA -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22218 BF_2 25.00 1.08 1256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22220 BF_2 21.01 3.22 560 642911647 XP_008200686.1 807 9.6e-84 PREDICTED: synapse-associated protein of 47 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 494 7.8e-49 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.22221 BF_2 57.16 5.32 737 642911647 XP_008200686.1 897 4.6e-94 PREDICTED: synapse-associated protein of 47 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 494 1.0e-48 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.22222 BF_2 28.31 0.83 1720 642930262 XP_971408.3 598 5.1e-59 PREDICTED: transmembrane protein 192 [Tribolium castaneum]>gi|270009437|gb|EFA05885.1| hypothetical protein TcasGA2_TC008697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NYE7 199 3.9e-14 Transmembrane protein 192 OS=Danio rerio GN=tmem192 PE=2 SV=1 PF04736 Eclosion hormone GO:0007218//GO:0018990 neuropeptide signaling pathway//ecdysis, chitin-based cuticle GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8309.22223 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22224 BF_2 14.00 0.70 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22227 BF_2 102.05 3.53 1495 91081511 XP_974643.1 958 8.0e-101 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 P70280 704 9.3e-73 Vesicle-associated membrane protein 7 OS=Mus musculus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.22228 BF_2 82.72 3.03 1428 91081511 XP_974643.1 958 7.6e-101 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 P70280 704 8.9e-73 Vesicle-associated membrane protein 7 OS=Mus musculus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.22231 BF_2 102.32 1.35 3469 642928365 XP_008192713.1 1314 9.7e-142 PREDICTED: uncharacterized protein LOC103312832 isoform X1 [Tribolium castaneum]>gi|270010785|gb|EFA07233.1| hypothetical protein TcasGA2_TC010590 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRJ8 423 8.3e-40 Protein Asterix OS=Drosophila melanogaster GN=CG10674 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3462 Predicted membrane protein Cluster-8309.22232 BF_2 98.77 1.46 3108 642935439 XP_008198009.1 2401 7.8e-268 PREDICTED: uncharacterized protein LOC100141521 [Tribolium castaneum] 642935438 XM_008199787.1 314 3.95237e-161 PREDICTED: Tribolium castaneum uncharacterized LOC100141521 (LOC100141521), mRNA K11791 DCAF15 DDB1- and CUL4-associated factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K11791 Q3SZD5 195 2.0e-13 DDB1- and CUL4-associated factor 15 OS=Bos taurus GN=DCAF15 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22234 BF_2 265.00 3.99 3063 91091862 XP_968876.1 2084 4.4e-231 PREDICTED: AP-3 complex subunit mu-1 [Tribolium castaneum]>gi|270000812|gb|EEZ97259.1| hypothetical protein TcasGA2_TC011059 [Tribolium castaneum] 665801097 XM_008550322.1 231 5.36902e-115 PREDICTED: Microplitis demolitor AP-3 complex subunit mu-1 (LOC103571962), mRNA K12398 AP3M AP-3 complex subunit mu http://www.genome.jp/dbget-bin/www_bget?ko:K12398 Q9Y2T2 1623 5.2e-179 AP-3 complex subunit mu-1 OS=Homo sapiens GN=AP3M1 PE=1 SV=1 PF06046 Exocyst complex component Sec6 GO:0016192//GO:0006886//GO:0006887 vesicle-mediated transport//intracellular protein transport//exocytosis -- -- GO:0030131//GO:0000145 clathrin adaptor complex//exocyst KOG0937 Adaptor complexes medium subunit family Cluster-8309.22236 BF_2 402.66 6.23 2990 755879427 XP_005185085.2 2139 1.8e-237 PREDICTED: pre-mRNA-splicing factor CWC22 homolog [Musca domestica] -- -- -- -- -- K13100 CWC22 pre-mRNA-splicing factor CWC22 http://www.genome.jp/dbget-bin/www_bget?ko:K13100 Q9VJ87 2106 5.0e-235 Pre-mRNA-splicing factor CWC22 homolog OS=Drosophila melanogaster GN=ncm PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2140 Uncharacterized conserved protein Cluster-8309.22240 BF_2 11.07 1.61 574 270006808 EFA03256.1 185 1.3e-11 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22241 BF_2 77.45 0.77 4478 270006808 EFA03256.1 1959 2.0e-216 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] 642924343 XM_008196035.1 453 0 PREDICTED: Tribolium castaneum voltage-gated potassium channel subunit beta-2 (LOC658668), mRNA K04883 KCNAB2 potassium voltage-gated channel Shaker-related subfamily A, beta member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04883 Q27955 988 3.3e-105 Voltage-gated potassium channel subunit beta-2 OS=Bos taurus GN=KCNAB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB Cluster-8309.22242 BF_2 39.26 0.53 3390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22244 BF_2 783.91 18.50 2060 189236562 XP_975592.2 838 9.0e-87 PREDICTED: programmed cell death protein 6 isoform X3 [Tribolium castaneum] 645007952 XM_008205559.1 80 3.13243e-31 PREDICTED: Nasonia vitripennis programmed cell death protein 6 (LOC100118174), transcript variant X2, mRNA -- -- -- -- P12815 605 3.9e-61 Programmed cell death protein 6 OS=Mus musculus GN=Pdcd6 PE=1 SV=2 PF13202//PF00036//PF10591//PF13833//PF13405//PF13499 EF hand//EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.22246 BF_2 39.56 0.57 3190 91084005 XP_975287.1 2193 1.1e-243 PREDICTED: EH domain-containing protein 1-like [Tribolium castaneum] 642924768 XM_970194.2 329 1.86142e-169 PREDICTED: Tribolium castaneum EH domain-containing protein 1-like (LOC664181), mRNA K12483 EHD1 EH domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12483 Q641Z6 1806 3.3e-200 EH domain-containing protein 1 OS=Rattus norvegicus GN=Ehd1 PE=1 SV=1 PF04670//PF13202//PF00036//PF03193//PF12763//PF01926//PF13499//PF13833//PF13405//PF08477 Gtr1/RagA G protein conserved region//EF hand//EF hand//Protein of unknown function, DUF258//Cytoskeletal-regulatory complex EF hand//50S ribosome-binding GTPase//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005509//GO:0005515//GO:0003924 GTP binding//calcium ion binding//protein binding//GTPase activity -- -- -- -- Cluster-8309.22247 BF_2 2.00 0.45 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22249 BF_2 24.01 5.05 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2225 BF_2 8.38 0.36 1256 270002172 EEZ98619.1 409 3.1e-37 hypothetical protein TcasGA2_TC001142 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 197 4.8e-14 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738//PF02230 Dienelactone hydrolase family//Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.22250 BF_2 323.21 7.42 2110 642922975 XP_008200476.1 1247 3.5e-134 PREDICTED: growth hormone-regulated TBC protein 1 [Tribolium castaneum]>gi|270006542|gb|EFA02990.1| hypothetical protein TcasGA2_TC010409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TC63 719 2.4e-74 Growth hormone-regulated TBC protein 1 OS=Homo sapiens GN=GRTP1 PE=1 SV=4 PF00947 Picornavirus core protein 2A GO:0006508//GO:0016032 proteolysis//viral process GO:0008233 peptidase activity GO:0005622 intracellular KOG2058 Ypt/Rab GTPase activating protein Cluster-8309.22251 BF_2 304.00 4.02 3447 478250321 ENN70818.1 2796 0.0e+00 hypothetical protein YQE_12483, partial [Dendroctonus ponderosae] 242015731 XM_002428456.1 231 6.05012e-115 Pediculus humanus corporis serine/threonine-protein kinase TBK1, putative, mRNA K05410 TBK1 TANK-binding kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05410 Q9WUN2 1152 2.4e-124 Serine/threonine-protein kinase TBK1 OS=Mus musculus GN=Tbk1 PE=1 SV=1 PF10104//PF07714//PF00069//PF05384 Di-sulfide bridge nucleocytoplasmic transport domain//Protein tyrosine kinase//Protein kinase domain//Sensor protein DegS GO:0006468//GO:0006611//GO:0006406//GO:0007165//GO:0006998 protein phosphorylation//protein export from nucleus//mRNA export from nucleus//signal transduction//nuclear envelope organization GO:0005524//GO:0004672//GO:0016301 ATP binding//protein kinase activity//kinase activity GO:0031965 nuclear membrane -- -- Cluster-8309.22252 BF_2 190.00 5.87 1642 642936089 XP_008198299.1 1531 3.1e-167 PREDICTED: transcription initiation factor TFIID subunit 2 [Tribolium castaneum]>gi|270013200|gb|EFA09648.1| hypothetical protein TcasGA2_TC011774 [Tribolium castaneum] -- -- -- -- -- K03128 TAF2 transcription initiation factor TFIID subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03128 Q24325 921 7.0e-98 Transcription initiation factor TFIID subunit 2 OS=Drosophila melanogaster GN=Taf2 PE=1 SV=2 PF02535//PF02985 ZIP Zinc transporter//HEAT repeat GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0005515//GO:0005488//GO:0008237//GO:0046873 protein binding//binding//metallopeptidase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG1932 TATA binding protein associated factor Cluster-8309.22253 BF_2 5.22 0.42 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22254 BF_2 331.91 2.36 6163 91077030 XP_967400.1 1924 3.2e-212 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1115 8.4e-120 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF07714//PF05028//PF03604//PF01029//PF06293//PF00069 Protein tyrosine kinase//Poly (ADP-ribose) glycohydrolase (PARG)//DNA directed RNA polymerase, 7 kDa subunit//NusB family//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0005975//GO:0006206//GO:0006355//GO:0006144//GO:0006468//GO:0006351 carbohydrate metabolic process//pyrimidine nucleobase metabolic process//regulation of transcription, DNA-templated//purine nucleobase metabolic process//protein phosphorylation//transcription, DNA-templated GO:0004672//GO:0004649//GO:0016773//GO:0003677//GO:0003723//GO:0003899//GO:0005524 protein kinase activity//poly(ADP-ribose) glycohydrolase activity//phosphotransferase activity, alcohol group as acceptor//DNA binding//RNA binding//DNA-directed RNA polymerase activity//ATP binding GO:0005730//GO:0016020 nucleolus//membrane KOG3087 Serine/threonine protein kinase Cluster-8309.22255 BF_2 275.51 4.61 2788 189237765 XP_001812950.1 1454 4.5e-158 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|642924439|ref|XP_008194298.1| PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum]>gi|270006791|gb|EFA03239.1| hypothetical protein TcasGA2_TC013171 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 O01735 1022 2.3e-109 Uncharacterized MFS-type transporter C09D4.1 OS=Caenorhabditis elegans GN=C09D4.1 PE=3 SV=2 PF00083//PF03137//PF07690 Sugar (and other) transporter//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.22256 BF_2 7.00 0.31 1230 3421457 AAC32224.1 1754 3.3e-193 cytoplasmic actin [Dreissena polymorpha] 558184753 XM_006128029.1 386 0 PREDICTED: Pelodiscus sinensis actin, cytoplasmic type 5-like (LOC102458214), mRNA K12315 ACTG2 actin, gamma-enteric smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12315 P41340 1741 4.3e-193 Actin-3 OS=Limulus polyphemus PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.22257 BF_2 235.38 4.04 2727 642933143 XP_008197274.1 3582 0.0e+00 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] 759040950 XM_011330978.1 45 1.19022e-11 PREDICTED: Cerapachys biroi UPF0378 protein KIAA0100 (LOC105274669), transcript variant X2, mRNA -- -- -- -- Q5SYL3 1445 2.0e-158 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 PF02601 Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG1910 Uncharacterized conserved protein Cluster-8309.22258 BF_2 27.62 1.34 1151 642933143 XP_008197274.1 1157 5.1e-124 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14667 550 5.1e-55 Protein KIAA0100 OS=Homo sapiens GN=KIAA0100 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1910 Uncharacterized conserved protein Cluster-8309.22260 BF_2 179.50 2.57 3213 91086355 XP_974424.1 1157 1.4e-123 PREDICTED: transcription factor TFIIIB component B'' homolog [Tribolium castaneum]>gi|270010281|gb|EFA06729.1| hypothetical protein TcasGA2_TC009660 [Tribolium castaneum] -- -- -- -- -- K15198 BDP1, TFC5 transcription factor TFIIIB component B'' http://www.genome.jp/dbget-bin/www_bget?ko:K15198 Q571C7 315 2.6e-27 Transcription factor TFIIIB component B'' homolog OS=Mus musculus GN=Bdp1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2009 Transcription initiation factor TFIIIB, Bdp1 subunit Cluster-8309.22261 BF_2 2.00 0.54 441 136032 P06708.1 600 7.6e-60 RecName: Full=Troponin C, isotype gamma [Pontastacus leptodactylus] 239949530 FJ790219.1 198 1.60159e-97 Homarus americanus troponin C isoform 2a mRNA, complete cds K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P06708 600 3.1e-61 Troponin C, isotype gamma OS=Astacus leptodactylus PE=1 SV=1 PF13202//PF03664//PF00036//PF12763//PF02881//PF13499//PF13833//PF13405 EF hand//Glycosyl hydrolase family 62//EF hand//Cytoskeletal-regulatory complex EF hand//SRP54-type protein, helical bundle domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain GO:0046373//GO:0006614//GO:0009117//GO:0005975 L-arabinose metabolic process//SRP-dependent cotranslational protein targeting to membrane//nucleotide metabolic process//carbohydrate metabolic process GO:0005515//GO:0046556//GO:0005525//GO:0005509 protein binding//alpha-L-arabinofuranosidase activity//GTP binding//calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.22262 BF_2 7.00 0.69 713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22266 BF_2 46.43 4.51 718 642930467 XP_008196414.1 664 4.7e-67 PREDICTED: exosome complex component RRP46 [Tribolium castaneum] -- -- -- -- -- K12590 RRP46, EXOSC5 exosome complex component RRP46 http://www.genome.jp/dbget-bin/www_bget?ko:K12590 Q9CRA8 416 1.1e-39 Exosome complex component RRP46 OS=Mus musculus GN=Exosc5 PE=1 SV=1 PF07827 KNTase C-terminal domain GO:0046677 response to antibiotic GO:0016779 nucleotidyltransferase activity -- -- KOG1069 Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 Cluster-8309.22267 BF_2 36.00 0.90 1960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22268 BF_2 103.56 0.96 4805 546677102 ERL88003.1 1067 5.9e-113 hypothetical protein D910_05392 [Dendroctonus ponderosae] -- -- -- -- -- K16751 C2CD3 C2 domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16751 Q4AC94 264 3.1e-21 C2 domain-containing protein 3 OS=Homo sapiens GN=C2CD3 PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22270 BF_2 35.00 1.28 1434 546681403 ERL91500.1 1175 5.3e-126 hypothetical protein D910_08830 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N5C7 425 2.0e-40 DTW domain-containing protein 1 OS=Homo sapiens GN=DTWD1 PE=1 SV=1 PF06512 Sodium ion transport-associated GO:0006814 sodium ion transport GO:0005248 voltage-gated sodium channel activity GO:0001518 voltage-gated sodium channel complex KOG3795 Uncharacterized conserved protein Cluster-8309.22272 BF_2 18.38 4.15 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22273 BF_2 68.00 0.93 3350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22274 BF_2 38.53 0.75 2426 642926835 XP_008195033.1 896 2.0e-93 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UK58 555 2.9e-55 Cyclin-L1 OS=Homo sapiens GN=CCNL1 PE=1 SV=1 PF02984 Cyclin, C-terminal domain GO:0000079//GO:0006396//GO:0006355 regulation of cyclin-dependent protein serine/threonine kinase activity//RNA processing//regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0005634 nucleus KOG0835 Cyclin L Cluster-8309.22276 BF_2 39.00 3.36 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22277 BF_2 157.72 2.13 3380 270013048 EFA09496.1 1145 3.7e-122 hypothetical protein TcasGA2_TC010990 [Tribolium castaneum] 242004796 XM_002423218.1 218 9.9956e-108 Pediculus humanus corporis RAB 3 and, putative, mRNA K07883 RAB3C Ras-related protein Rab-3C http://www.genome.jp/dbget-bin/www_bget?ko:K07883 P25228 1074 2.6e-115 Ras-related protein Rab-3 OS=Drosophila melanogaster GN=Rab3 PE=1 SV=1 PF01926//PF08477//PF02421//PF06821//PF00025//PF04451//PF03193//PF04670//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//Serine hydrolase//ADP-ribosylation factor family//Large eukaryotic DNA virus major capsid protein//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit GO:0007165//GO:0007186//GO:0015684//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//ferrous iron transport//small GTPase mediated signal transduction GO:0016787//GO:0031683//GO:0015093//GO:0003924//GO:0005198//GO:0019001//GO:0004871//GO:0005525 hydrolase activity//G-protein beta/gamma-subunit complex binding//ferrous iron transmembrane transporter activity//GTPase activity//structural molecule activity//guanyl nucleotide binding//signal transducer activity//GTP binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.22278 BF_2 31.64 0.45 3258 642934172 XP_969292.2 1143 6.1e-122 PREDICTED: ras-related protein Rab-3 isoform X1 [Tribolium castaneum] 242004796 XM_002423218.1 218 9.63092e-108 Pediculus humanus corporis RAB 3 and, putative, mRNA K07883 RAB3C Ras-related protein Rab-3C http://www.genome.jp/dbget-bin/www_bget?ko:K07883 P25228 1074 2.5e-115 Ras-related protein Rab-3 OS=Drosophila melanogaster GN=Rab3 PE=1 SV=1 PF00503//PF04670//PF00071//PF03193//PF04451//PF02421//PF06821//PF00025//PF08477//PF01926 G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family//Protein of unknown function, DUF258//Large eukaryotic DNA virus major capsid protein//Ferrous iron transport protein B//Serine hydrolase//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007165//GO:0007186//GO:0007264//GO:0015684 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0016787//GO:0031683//GO:0005198//GO:0003924//GO:0005525//GO:0019001//GO:0004871 ferrous iron transmembrane transporter activity//hydrolase activity//G-protein beta/gamma-subunit complex binding//structural molecule activity//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.2228 BF_2 2.00 0.38 507 805078 AAC47272.1 287 1.7e-23 integrase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O93209 136 2.3e-07 Pro-Pol polyprotein OS=Feline foamy virus GN=pol PE=3 SV=1 PF03089//PF00665 Recombination activating protein 2//Integrase core domain GO:0015074//GO:0006310 DNA integration//DNA recombination GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.22281 BF_2 245.29 2.81 3938 91088597 XP_973576.1 880 2.3e-91 PREDICTED: ketimine reductase mu-crystallin [Tribolium castaneum]>gi|270012255|gb|EFA08703.1| hypothetical protein TcasGA2_TC006374 [Tribolium castaneum] -- -- -- -- -- K18258 CRYM thiomorpholine-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18258 Q14894 431 1.1e-40 Ketimine reductase mu-crystallin OS=Homo sapiens GN=CRYM PE=1 SV=1 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG3007 Mu-crystallin Cluster-8309.22285 BF_2 154.00 11.55 845 270015167 EFA11615.1 402 1.3e-36 hypothetical protein TcasGA2_TC030555, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62954 266 3.2e-22 Bladder cancer-associated protein OS=Bos taurus GN=BLCAP PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4489 Uncharacterized conserved protein BC10 (implicated in bladder cancer in humans) Cluster-8309.22286 BF_2 102.00 2.71 1862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22289 BF_2 228.04 3.19 3282 642932843 XP_974466.2 2087 2.1e-231 PREDICTED: ralBP1-associated Eps domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54916 383 3.4e-35 RalBP1-associated Eps domain-containing protein 1 OS=Mus musculus GN=Reps1 PE=1 SV=2 PF13202//PF12763//PF13405//PF00036//PF13499//PF08057 EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF hand//EF-hand domain pair//Erythromycin resistance leader peptide GO:0046677 response to antibiotic GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1955 Ral-GTPase effector RALBP1 Cluster-8309.22290 BF_2 280.96 3.88 3314 642932843 XP_974466.2 2087 2.1e-231 PREDICTED: ralBP1-associated Eps domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54916 383 3.4e-35 RalBP1-associated Eps domain-containing protein 1 OS=Mus musculus GN=Reps1 PE=1 SV=2 PF12763//PF13202//PF08057//PF13499//PF13405//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//Erythromycin resistance leader peptide//EF-hand domain pair//EF-hand domain//EF hand GO:0046677 response to antibiotic GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1955 Ral-GTPase effector RALBP1 Cluster-8309.22291 BF_2 157.96 9.26 1001 642913226 XP_975254.2 542 9.2e-53 PREDICTED: protein CutA homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K03926 cutA periplasmic divalent cation tolerance protein http://www.genome.jp/dbget-bin/www_bget?ko:K03926 Q66KY3 393 7.2e-37 Protein CutA homolog OS=Xenopus laevis GN=cuta PE=2 SV=2 PF03091 CutA1 divalent ion tolerance protein GO:0010038 response to metal ion -- -- -- -- KOG3338 Divalent cation tolerance-related protein Cluster-8309.22292 BF_2 531.64 17.10 1588 642936600 XP_008198502.1 838 6.9e-87 PREDICTED: NECAP-like protein CG9132 [Tribolium castaneum]>gi|642936602|ref|XP_972648.2| PREDICTED: NECAP-like protein CG9132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXB0 698 4.9e-72 NECAP-like protein CG9132 OS=Drosophila melanogaster GN=CG9132 PE=2 SV=1 PF07933 Protein of unknown function (DUF1681) GO:0006897 endocytosis -- -- GO:0016020 membrane KOG2500 Uncharacterized conserved protein Cluster-8309.22293 BF_2 241.95 2.42 4462 642929396 XP_008195819.1 2811 0.0e+00 PREDICTED: neogenin isoform X3 [Tribolium castaneum] -- -- -- -- -- K06766 NEO1 neogenin http://www.genome.jp/dbget-bin/www_bget?ko:K06766 Q90610 1000 1.3e-106 Neogenin (Fragment) OS=Gallus gallus PE=2 SV=1 PF16656//PF00041//PF06583//PF08465//PF01108 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Neogenin C-terminus//Thymidine kinase from Herpesvirus C-terminal//Tissue factor GO:0006771//GO:0006206//GO:0006230//GO:0019497 riboflavin metabolic process//pyrimidine nucleobase metabolic process//TMP biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005524//GO:0004797//GO:0005515 acid phosphatase activity//metal ion binding//ATP binding//thymidine kinase activity//protein binding GO:0016021 integral component of membrane KOG4221 Receptor mediating netrin-dependent axon guidance Cluster-8309.22296 BF_2 3.00 1.64 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22299 BF_2 687.00 6.22 4908 91080109 XP_967250.1 2070 3.0e-229 PREDICTED: uncharacterized protein LOC655596 isoform X1 [Tribolium castaneum]>gi|270003190|gb|EEZ99637.1| hypothetical protein TcasGA2_TC002393 [Tribolium castaneum] -- -- -- -- -- K15559 RTT103 regulator of Ty1 transposition protein 103 http://www.genome.jp/dbget-bin/www_bget?ko:K15559 Q9CSU0 773 3.0e-80 Regulation of nuclear pre-mRNA domain-containing protein 1B OS=Mus musculus GN=Rprd1b PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.22302 BF_2 4.00 1.12 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22303 BF_2 104.02 2.25 2220 642910216 XP_008198443.1 2268 1.5e-252 PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum]>gi|642910218|ref|XP_967637.2| PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum] 642910217 XM_962544.2 453 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC655987), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 P49803 1449 5.7e-159 Regulator of G-protein signaling 7 OS=Rattus norvegicus GN=Rgs7 PE=2 SV=2 PF00610//PF00631 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//GGL domain GO:0035556//GO:0007186//GO:0007165 intracellular signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex KOG3589 G protein signaling regulators Cluster-8309.22313 BF_2 92.92 1.72 2553 91092388 XP_968476.1 2123 1.1e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.0984e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22314 BF_2 70.16 1.47 2283 91092388 XP_968476.1 1718 9.1e-189 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 9.80619e-22 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22315 BF_2 65.00 4.72 863 91079538 XP_970846.1 1156 5.0e-124 PREDICTED: uncharacterized protein LOC659449 [Tribolium castaneum]>gi|270003424|gb|EEZ99871.1| hypothetical protein TcasGA2_TC002653 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04144//PF11480 SCAMP family//Colicin-E5 Imm protein GO:0030153//GO:0015031 bacteriocin immunity//protein transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22318 BF_2 502.61 10.39 2310 91092760 XP_973551.1 1792 2.4e-197 PREDICTED: protein BCL9 homolog [Tribolium castaneum]>gi|270014793|gb|EFA11241.1| hypothetical protein TcasGA2_TC010773 [Tribolium castaneum] 642911481 XM_968458.3 460 0 PREDICTED: Tribolium castaneum protein BCL9 homolog (LOC662357), mRNA -- -- -- -- Q961D9 243 4.1e-19 Protein BCL9 homolog OS=Drosophila melanogaster GN=lgs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22320 BF_2 5.00 0.38 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22322 BF_2 15.00 4.12 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22327 BF_2 4.99 0.69 588 270003816 EFA00264.1 229 1.1e-16 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V5M3 128 2.2e-06 Longitudinals lacking protein, isoforms N/O/W/X/Y OS=Drosophila melanogaster GN=lola PE=1 SV=3 PF16622//PF13912//PF00301//PF02892//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Rubredoxin//BED zinc finger//Zinc finger, C2H2 type -- -- GO:0005506//GO:0046872//GO:0003677 iron ion binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.22330 BF_2 105.00 1.69 2892 557018159 XP_006009466.1 622 1.4e-61 PREDICTED: uncharacterized protein LOC102349681 isoform X1 [Latimeria chalumnae]>gi|557018161|ref|XP_006009467.1| PREDICTED: uncharacterized protein LOC102349681 isoform X2 [Latimeria chalumnae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.22331 BF_2 88.61 0.72 5456 642915644 XP_972006.3 2982 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.3e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.22340 BF_2 110.00 4.13 1401 91091400 XP_973804.1 1140 5.9e-122 PREDICTED: THO complex subunit 6 [Tribolium castaneum]>gi|270013056|gb|EFA09504.1| hypothetical protein TcasGA2_TC011605 [Tribolium castaneum] -- -- -- -- -- K13175 THOC6 THO complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13175 Q5XJS5 496 1.1e-48 THO complex subunit 6 homolog OS=Danio rerio GN=thoc6 PE=2 SV=1 PF04670//PF16906//PF00400 Gtr1/RagA G protein conserved region//Ribosomal proteins L26 eukaryotic, L24P archaeal//WD domain, G-beta repeat GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005525//GO:0003735//GO:0005515 GTP binding//structural constituent of ribosome//protein binding GO:0005840//GO:0015934 ribosome//large ribosomal subunit -- -- Cluster-8309.22341 BF_2 230.00 9.80 1269 478260562 ENN80265.1 224 8.8e-16 hypothetical protein YQE_03259, partial [Dendroctonus ponderosae]>gi|546685302|gb|ERL94829.1| hypothetical protein D910_12102 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22343 BF_2 20.36 0.69 1516 478258343 ENN78462.1 831 4.3e-86 hypothetical protein YQE_05100, partial [Dendroctonus ponderosae] -- -- -- -- -- K01389 MME neprilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01389 Q18673 411 8.9e-39 Neprilysin-1 OS=Caenorhabditis elegans GN=nep-1 PE=1 SV=3 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.22345 BF_2 31.59 0.43 3388 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.5e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22346 BF_2 20.77 0.34 2853 642912555 XP_008200909.1 728 7.1e-74 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q58DH2 407 4.9e-38 Phosphatidylserine decarboxylase proenzyme OS=Bos taurus GN=PISD PE=2 SV=1 PF02666 Phosphatidylserine decarboxylase GO:0006563//GO:0006566//GO:0006544//GO:0008654//GO:0046486 L-serine metabolic process//threonine metabolic process//glycine metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.22348 BF_2 467.01 12.02 1912 91089427 XP_974449.1 1703 4.2e-187 PREDICTED: switch-associated protein 70 [Tribolium castaneum]>gi|270012554|gb|EFA09002.1| hypothetical protein TcasGA2_TC006709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F4B2 332 1.6e-29 Switch-associated protein 70 OS=Gallus gallus GN=SWAP70 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22351 BF_2 63.21 1.27 2373 270008433 EFA04881.1 210 6.9e-14 hypothetical protein TcasGA2_TC014942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22356 BF_2 66.00 4.83 859 642928987 XP_008195646.1 730 1.3e-74 PREDICTED: WD repeat-containing protein 74 [Tribolium castaneum]>gi|270009716|gb|EFA06164.1| hypothetical protein TcasGA2_TC009011 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58D06 174 1.5e-11 WD repeat-containing protein 74 OS=Bos taurus GN=WDR74 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3881 Uncharacterized conserved protein Cluster-8309.22357 BF_2 414.45 7.50 2599 642937696 XP_008198905.1 2543 2.2e-284 PREDICTED: cysteine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270000778|gb|EEZ97225.1| hypothetical protein TcasGA2_TC011023 [Tribolium castaneum] 768412406 XM_011569978.1 130 6.36103e-59 PREDICTED: Plutella xylostella cysteine--tRNA ligase, cytoplasmic (LOC105397950), mRNA K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q7KN90 2088 5.3e-233 Cysteine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-cys PE=1 SV=1 PF13465//PF01322//PF09334//PF00133 Zinc-finger double domain//Cytochrome C'//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V) GO:0006118//GO:0006418 obsolete electron transport//tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0009055//GO:0020037//GO:0004812//GO:0005506//GO:0046872 ATP binding//nucleotide binding//electron carrier activity//heme binding//aminoacyl-tRNA ligase activity//iron ion binding//metal ion binding -- -- KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.22359 BF_2 21.83 0.44 2342 642938529 XP_967703.2 1975 1.5e-218 PREDICTED: RUN domain-containing protein 1-like [Tribolium castaneum]>gi|270015593|gb|EFA12041.1| hypothetical protein TcasGA2_TC001458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96C34 790 1.6e-82 RUN domain-containing protein 1 OS=Homo sapiens GN=RUNDC1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3759 Uncharacterized RUN domain protein Cluster-8309.22361 BF_2 47.00 0.65 3297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22362 BF_2 14.00 0.56 1338 -- -- -- -- -- 761231605 KM881639.1 1338 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q9MUY0 2152 1.0e-240 Maturase K OS=Molinia caerulea GN=matK PE=3 SV=1 PF01348 Type II intron maturase GO:0006397 mRNA processing -- -- -- -- -- -- Cluster-8309.22365 BF_2 6.00 0.33 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22369 BF_2 18.88 1.37 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22370 BF_2 145.12 15.26 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22372 BF_2 16.09 0.48 1698 332375596 AEE62939.1 305 4.7e-25 unknown [Dendroctonus ponderosae] 830186132 XM_004692871.2 69 3.35131e-25 PREDICTED: Condylura cristata vesicle-associated membrane protein 1 (synaptobrevin 1) (VAMP1), mRNA K13505 VAMP3 vesicle-associated membrane protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13505 O02495 241 5.1e-19 Synaptobrevin-1 OS=Caenorhabditis elegans GN=snb-1 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.22374 BF_2 1.00 0.57 356 270016078 EFA12526.1 298 6.4e-25 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 183 5.7e-13 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.22375 BF_2 2.00 2.92 299 270016078 EFA12526.1 341 5.6e-30 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 233 7.6e-19 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22376 BF_2 63.67 1.87 1709 478266693 ENN82870.1 1309 1.8e-141 hypothetical protein YQE_00763, partial [Dendroctonus ponderosae]>gi|546684080|gb|ERL93799.1| hypothetical protein D910_11085 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TS68 778 2.8e-81 Putative methyltransferase NSUN6 OS=Mus musculus GN=Nsun6 PE=2 SV=2 PF01728//PF01472//PF01189 FtsJ-like methyltransferase//PUA domain//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0003723//GO:0008168 RNA binding//methyltransferase activity -- -- KOG1122 tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) Cluster-8309.22377 BF_2 115.00 1.93 2779 91084311 XP_976363.1 301 2.3e-24 PREDICTED: uncharacterized protein LOC660880 [Tribolium castaneum]>gi|270008806|gb|EFA05254.1| hypothetical protein TcasGA2_TC015406 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05393 Human adenovirus early E3A glycoprotein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.2238 BF_2 4.00 0.40 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22381 BF_2 3.00 4.03 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22382 BF_2 17.10 0.52 1663 153792270 NP_001093280.1 350 2.8e-30 malate dehydrogenase [Bombyx mori]>gi|95103050|gb|ABF51466.1| malate dehydrogenase [Bombyx mori] -- -- -- -- -- K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P78715 165 3.3e-10 Malic enzyme, hydrogenosomal OS=Neocallimastix frontalis PE=1 SV=1 -- -- GO:0006108//GO:0044710//GO:0006099 malate metabolic process//single-organism metabolic process//tricarboxylic acid cycle GO:0016616//GO:0004470//GO:0000166 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//malic enzyme activity//nucleotide binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.22383 BF_2 401.90 8.83 2191 546676350 ERL87377.1 1897 1.5e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.4e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.22384 BF_2 407.00 27.12 915 642923408 XP_974329.2 491 6.9e-47 PREDICTED: small nuclear ribonucleoprotein-associated protein B [Tribolium castaneum]>gi|270008314|gb|EFA04762.1| hypothetical protein TcasGA2_TC030631 [Tribolium castaneum] 831297156 XM_012824943.1 36 3.92675e-07 PREDICTED: Clupea harengus small nuclear ribonucleoprotein polypeptides B and B1 (snrpb), mRNA K11086 SNRPB, SMB small nuclear ribonucleoprotein B and B' http://www.genome.jp/dbget-bin/www_bget?ko:K11086 Q05856 371 2.3e-34 Small nuclear ribonucleoprotein-associated protein B OS=Drosophila melanogaster GN=SmB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3168 U1 snRNP component Cluster-8309.22386 BF_2 12.61 0.68 1068 642918245 XP_008191428.1 234 5.1e-17 PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum]>gi|642918247|ref|XP_008191429.1| PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F753 159 1.0e-09 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF02230//PF00326 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.22387 BF_2 163.39 8.62 1080 642918245 XP_008191428.1 265 1.3e-20 PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum]>gi|642918247|ref|XP_008191429.1| PREDICTED: monoacylglycerol lipase ABHD12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F753 185 1.0e-12 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22388 BF_2 4.67 0.42 755 546676804 ERL87750.1 568 6.7e-56 hypothetical protein D910_05139 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 B4F753 267 2.2e-22 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF01764//PF14993//PF07859//PF02230//PF00975 Lipase (class 3)//Neuropeptide S precursor protein//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Thioesterase domain GO:0008152//GO:0007218//GO:0006629//GO:0009058 metabolic process//neuropeptide signaling pathway//lipid metabolic process//biosynthetic process GO:0016788//GO:0016787 hydrolase activity, acting on ester bonds//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.22390 BF_2 89.03 0.31 12211 270013018 EFA09466.1 6357 0.0e+00 hypothetical protein TcasGA2_TC010960 [Tribolium castaneum] 667677299 AE014296.5 67 3.17159e-23 Drosophila melanogaster chromosome 3L K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8WXX0 4321 0.0e+00 Dynein heavy chain 7, axonemal OS=Homo sapiens GN=DNAH7 PE=1 SV=2 PF05418//PF00580//PF01637//PF04851//PF00910//PF02601//PF01695//PF07728//PF00158//PF00004//PF00437//PF03028//PF07724 Apovitellenin I (Apo-VLDL-II)//UvrD/REP helicase N-terminal domain//Archaeal ATPase//Type III restriction enzyme, res subunit//RNA helicase//Exonuclease VII, large subunit//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Dynein heavy chain and region D6 of dynein motor//AAA domain (Cdc48 subfamily) GO:0006308//GO:0006629//GO:0007017//GO:0006355//GO:0006810//GO:0007018 DNA catabolic process//lipid metabolic process//microtubule-based process//regulation of transcription, DNA-templated//transport//microtubule-based movement GO:0003724//GO:0008855//GO:0004857//GO:0003777//GO:0003723//GO:0003677//GO:0016887//GO:0008134//GO:0005524//GO:0016787 RNA helicase activity//exodeoxyribonuclease VII activity//enzyme inhibitor activity//microtubule motor activity//RNA binding//DNA binding//ATPase activity//transcription factor binding//ATP binding//hydrolase activity GO:0005874//GO:0005667//GO:0030286//GO:0042627//GO:0009318 microtubule//transcription factor complex//dynein complex//chylomicron//exodeoxyribonuclease VII complex -- -- Cluster-8309.22392 BF_2 189.33 4.77 1947 91089625 XP_973443.1 740 2.0e-75 PREDICTED: tudor and KH domain-containing protein [Tribolium castaneum]>gi|270012611|gb|EFA09059.1| hypothetical protein TcasGA2_TC006774 [Tribolium castaneum] -- -- -- -- -- K18406 TDRKH, TDRD2 tudor domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18406 Q80VL1 302 5.0e-26 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF07650//PF13014//PF13184//PF00013 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.22396 BF_2 155.69 1.76 3978 642920232 XP_008192259.1 462 6.9e-43 PREDICTED: uncharacterized protein LOC103312697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09003 Bacteriophage lambda integrase, N-terminal domain GO:0015074 DNA integration GO:0003677//GO:0008907 DNA binding//integrase activity -- -- -- -- Cluster-8309.22397 BF_2 82.56 0.93 3982 91091444 XP_972566.1 1578 2.7e-172 PREDICTED: succinate-semialdehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270000977|gb|EEZ97424.1| hypothetical protein TcasGA2_TC011254 [Tribolium castaneum] -- -- -- -- -- K00139 ALDH5A1 succinate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00139 Q3MSM3 1099 3.9e-118 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Hylobates lar GN=ALDH5A1 PE=2 SV=1 PF00013//PF00171 KH domain//Aldehyde dehydrogenase family GO:0055114//GO:0006570//GO:0008152//GO:0009450 oxidation-reduction process//tyrosine metabolic process//metabolic process//gamma-aminobutyric acid catabolic process GO:0016491//GO:0009013//GO:0003723 oxidoreductase activity//succinate-semialdehyde dehydrogenase [NAD(P)+] activity//RNA binding -- -- KOG2451 Aldehyde dehydrogenase Cluster-8309.22398 BF_2 34.75 0.34 4582 270006670 EFA03118.1 666 1.8e-66 hypothetical protein TcasGA2_TC013028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205 WH2 motif -- -- GO:0003779 actin binding -- -- -- -- Cluster-8309.22402 BF_2 59.45 1.07 2614 556993813 XP_006001025.1 197 2.4e-12 PREDICTED: zinc finger protein 729-like [Latimeria chalumnae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5T619 185 2.5e-12 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1 PF13465//PF00096//PF01155//PF07975//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006281//GO:0006464 DNA repair//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.22405 BF_2 461.62 6.56 3231 642924249 XP_966647.3 2025 3.2e-224 PREDICTED: palmitoyltransferase ZDHHC18 [Tribolium castaneum] -- -- -- -- -- K16675 ZDHHC9_14_18 palmitoyltransferase ZDHHC9/14/18 http://www.genome.jp/dbget-bin/www_bget?ko:K16675 Q8BQQ1 1169 2.4e-126 Probable palmitoyltransferase ZDHHC14 OS=Mus musculus GN=Zdhhc14 PE=2 SV=1 PF13520//PF03699//PF01529//PF02419 Amino acid permease//Uncharacterised protein family (UPF0182)//DHHC palmitoyltransferase//PsbL protein GO:0006865//GO:0015979//GO:0003333 amino acid transport//photosynthesis//amino acid transmembrane transport GO:0015171//GO:0008270 amino acid transmembrane transporter activity//zinc ion binding GO:0016021//GO:0009539//GO:0009523//GO:0016020 integral component of membrane//photosystem II reaction center//photosystem II//membrane KOG1311 DHHC-type Zn-finger proteins Cluster-8309.22406 BF_2 40.05 0.46 3967 642924249 XP_966647.3 1292 3.9e-139 PREDICTED: palmitoyltransferase ZDHHC18 [Tribolium castaneum] -- -- -- -- -- K16675 ZDHHC9_14_18 palmitoyltransferase ZDHHC9/14/18 http://www.genome.jp/dbget-bin/www_bget?ko:K16675 Q8BQQ1 1009 1.1e-107 Probable palmitoyltransferase ZDHHC14 OS=Mus musculus GN=Zdhhc14 PE=2 SV=1 PF05493//PF13520//PF02419//PF03699//PF01529 ATP synthase subunit H//Amino acid permease//PsbL protein//Uncharacterised protein family (UPF0182)//DHHC palmitoyltransferase GO:0003333//GO:0015992//GO:0015979//GO:0006865//GO:0015991 amino acid transmembrane transport//proton transport//photosynthesis//amino acid transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0008270//GO:0015171 hydrogen ion transmembrane transporter activity//zinc ion binding//amino acid transmembrane transporter activity GO:0016020//GO:0009539//GO:0009523//GO:0033179//GO:0016021 membrane//photosystem II reaction center//photosystem II//proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG1311 DHHC-type Zn-finger proteins Cluster-8309.22407 BF_2 554.53 9.94 2620 330417873 NP_001193392.1 1663 2.5e-182 glutathione S-transferase C-terminal domain-containing protein [Tribolium castaneum]>gi|270010443|gb|EFA06891.1| hypothetical protein TcasGA2_TC009836 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29LT4 994 3.8e-106 Glutathione S-transferase C-terminal domain-containing protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA10313 PE=3 SV=1 PF05439//PF05206//PF02390//PF02527//PF05175//PF01135 Jumping translocation breakpoint protein (JTB)//Methyltransferase TRM13//Putative methyltransferase//rRNA small subunit methyltransferase G//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006464//GO:0046500//GO:0006396//GO:0008033//GO:0006400//GO:0000154//GO:0009451//GO:0006479//GO:0006364 cellular protein modification process//S-adenosylmethionine metabolic process//RNA processing//tRNA processing//tRNA modification//rRNA modification//RNA modification//protein methylation//rRNA processing GO:0008649//GO:0004719//GO:0008176//GO:0008168 rRNA methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm -- -- Cluster-8309.22408 BF_2 123.47 2.41 2432 330417873 NP_001193392.1 1663 2.3e-182 glutathione S-transferase C-terminal domain-containing protein [Tribolium castaneum]>gi|270010443|gb|EFA06891.1| hypothetical protein TcasGA2_TC009836 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29LT4 994 3.6e-106 Glutathione S-transferase C-terminal domain-containing protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA10313 PE=3 SV=1 PF05439//PF05206//PF02527//PF02390//PF05175//PF01135 Jumping translocation breakpoint protein (JTB)//Methyltransferase TRM13//rRNA small subunit methyltransferase G//Putative methyltransferase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006364//GO:0009451//GO:0006479//GO:0046500//GO:0006396//GO:0008033//GO:0006400//GO:0000154//GO:0006464 rRNA processing//RNA modification//protein methylation//S-adenosylmethionine metabolic process//RNA processing//tRNA processing//tRNA modification//rRNA modification//cellular protein modification process GO:0004719//GO:0008176//GO:0008168//GO:0008649 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//rRNA methyltransferase activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.22410 BF_2 10.00 1.66 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22411 BF_2 31.92 0.62 2444 91079416 XP_967408.1 1380 1.5e-149 PREDICTED: microspherule protein 1 isoform X1 [Tribolium castaneum]>gi|270004380|gb|EFA00828.1| hypothetical protein TcasGA2_TC003716 [Tribolium castaneum] -- -- -- -- -- K11674 MCRS1, INO80Q microspherule protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11674 Q96EZ8 838 4.4e-88 Microspherule protein 1 OS=Homo sapiens GN=MCRS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2293 Daxx-interacting protein MSP58/p78, contains FHA domain Cluster-8309.22412 BF_2 5.00 1.03 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22418 BF_2 31.53 1.24 1354 91080473 XP_970438.1 434 4.2e-40 PREDICTED: mitochondrial inner membrane protease subunit 1 [Tribolium castaneum]>gi|270005561|gb|EFA02009.1| hypothetical protein TcasGA2_TC007631 [Tribolium castaneum] -- -- -- -- -- K09647 IMP1 mitochondrial inner membrane protease subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09647 Q96LU5 305 1.6e-26 Mitochondrial inner membrane protease subunit 1 OS=Homo sapiens GN=IMMP1L PE=2 SV=1 -- -- GO:0006508 proteolysis GO:0008236 serine-type peptidase activity GO:0016021 integral component of membrane KOG0171 Mitochondrial inner membrane protease, subunit IMP1 Cluster-8309.22419 BF_2 2.00 0.62 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22420 BF_2 3.00 0.91 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22421 BF_2 120.11 4.75 1346 641656545 XP_008180002.1 252 5.3e-19 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 3 isoform X3 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q92626 180 4.8e-12 Peroxidasin homolog OS=Homo sapiens GN=PXDN PE=1 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22422 BF_2 6.00 2.57 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22423 BF_2 30.08 1.20 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22425 BF_2 15.72 1.53 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22428 BF_2 192.85 6.03 1624 642935048 XP_008199920.1 1059 1.7e-112 PREDICTED: polymerase delta-interacting protein 3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG81 182 3.4e-12 Polymerase delta-interacting protein 3 OS=Mus musculus GN=Poldip3 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.22430 BF_2 24.38 0.80 1567 642929649 XP_008195920.1 175 5.2e-10 PREDICTED: uncharacterized protein LOC664363 isoform X7 [Tribolium castaneum]>gi|270010570|gb|EFA07018.1| hypothetical protein TcasGA2_TC009989 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22431 BF_2 185.53 3.17 2738 642917250 XP_967285.3 1472 3.6e-160 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X2 [Tribolium castaneum] 642917249 XM_962192.3 115 1.46087e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q8BLY1 323 2.6e-28 SPARC-related modular calcium-binding protein 1 OS=Mus musculus GN=Smoc1 PE=2 SV=2 PF13405//PF00050//PF10591//PF00036//PF13499//PF07648//PF13202 EF-hand domain//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//Kazal-type serine protease inhibitor domain//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.22436 BF_2 57.94 2.92 1116 150416593 ABF60889.2 204 1.6e-13 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.22437 BF_2 209.35 4.77 2123 642939750 XP_008195710.1 1352 2.3e-146 PREDICTED: protein FAM43A, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2R8 308 1.1e-26 Protein FAM43A OS=Homo sapiens GN=FAM43A PE=2 SV=2 PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4448 Uncharacterized conserved protein, contains phosphotyrosine interaction (PI) domain Cluster-8309.22440 BF_2 13.12 0.73 1043 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05104 Ribosome receptor lysine/proline rich region GO:0015031 protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.22442 BF_2 103.03 2.91 1768 642933608 XP_008197492.1 1967 9.4e-218 PREDICTED: stress-activated protein kinase JNK isoform X1 [Tribolium castaneum] 170029895 XM_001842775.1 532 0 Culex quinquefasciatus jnk, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1693 2.3e-187 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF03708//PF06293//PF00069//PF07714 Avian retrovirus envelope protein, gp85//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0019031//GO:0016020 viral envelope//membrane -- -- Cluster-8309.22443 BF_2 253.29 4.58 2599 189237609 XP_968824.2 1850 5.1e-204 PREDICTED: sodium/potassium/calcium exchanger 3-like isoform X1 [Tribolium castaneum] 347972526 XM_563948.4 154 2.89735e-72 Anopheles gambiae str. PEST AGAP010977-PA (AgaP_AGAP010977) mRNA, partial cds K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q49SH1 712 1.9e-73 Sodium/potassium/calcium exchanger 5 OS=Danio rerio GN=slc24a5 PE=2 SV=1 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.22447 BF_2 356.02 1.75 8788 91093683 XP_970017.1 1672 7.5e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 2.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF04136//PF00115//PF01395 Acyltransferase//Sec34-like family//Cytochrome C and Quinol oxidase polypeptide I//PBP/GOBP family GO:0006118//GO:0015992//GO:0055114//GO:0009060//GO:0006123//GO:0006886//GO:0008152 obsolete electron transport//proton transport//oxidation-reduction process//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//metabolic process GO:0005506//GO:0005549//GO:0009055//GO:0020037//GO:0004129//GO:0016746 iron ion binding//odorant binding//electron carrier activity//heme binding//cytochrome-c oxidase activity//transferase activity, transferring acyl groups GO:0005801//GO:0016021//GO:0016020//GO:0045277 cis-Golgi network//integral component of membrane//membrane//respiratory chain complex IV KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.22448 BF_2 207.22 0.99 9068 91093683 XP_970017.1 1672 7.8e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 2.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF04136//PF00115//PF01395 Acyltransferase//Sec34-like family//Cytochrome C and Quinol oxidase polypeptide I//PBP/GOBP family GO:0008152//GO:0006123//GO:0009060//GO:0006886//GO:0006118//GO:0055114//GO:0015992 metabolic process//mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration//intracellular protein transport//obsolete electron transport//oxidation-reduction process//proton transport GO:0016746//GO:0009055//GO:0004129//GO:0020037//GO:0005549//GO:0005506 transferase activity, transferring acyl groups//electron carrier activity//cytochrome-c oxidase activity//heme binding//odorant binding//iron ion binding GO:0045277//GO:0016020//GO:0016021//GO:0005801 respiratory chain complex IV//membrane//integral component of membrane//cis-Golgi network KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.22449 BF_2 46.52 0.78 2796 642910948 XP_008193477.1 2947 0.0e+00 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 2067 1.6e-230 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF02897//PF00326 Prolyl oligopeptidase, N-terminal beta-propeller domain//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0070008//GO:0008236//GO:0004252 serine-type exopeptidase activity//serine-type peptidase activity//serine-type endopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.2245 BF_2 4.00 0.31 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22450 BF_2 14.00 0.99 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22452 BF_2 53.74 0.58 4185 642932116 XP_008196861.1 1357 1.2e-146 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1068 1.6e-114 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00448//PF00437//PF00004//PF04408//PF05279//PF00158//PF00931//PF00270//PF02562//PF01637//PF04851//PF00005 SRP54-type protein, GTPase domain//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Helicase associated domain (HA2)//Aspartyl beta-hydroxylase N-terminal region//Sigma-54 interaction domain//NB-ARC domain//DEAD/DEAH box helicase//PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter GO:0006355//GO:0006810//GO:0006614 regulation of transcription, DNA-templated//transport//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0003676//GO:0016887//GO:0043531//GO:0008134//GO:0005524//GO:0004386//GO:0003677//GO:0016787 GTP binding//nucleic acid binding//ATPase activity//ADP binding//transcription factor binding//ATP binding//helicase activity//DNA binding//hydrolase activity GO:0016020//GO:0005667 membrane//transcription factor complex KOG0920 ATP-dependent RNA helicase A Cluster-8309.22454 BF_2 79.35 1.29 2865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22457 BF_2 94.94 0.91 4641 270011645 EFA08093.1 206 3.9e-13 hypothetical protein TcasGA2_TC005697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009522//GO:0009579//GO:0016021 photosystem I//thylakoid//integral component of membrane -- -- Cluster-8309.22458 BF_2 199.77 2.21 4070 642932116 XP_008196861.1 2518 2.8e-281 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1875 4.1e-208 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00005//PF04851//PF02562//PF01637//PF00270//PF00931//PF14532//PF00158//PF04408//PF00437//PF00448 ABC transporter//Type III restriction enzyme, res subunit//PhoH-like protein//Archaeal ATPase//DEAD/DEAH box helicase//NB-ARC domain//Sigma-54 interaction domain//Sigma-54 interaction domain//Helicase associated domain (HA2)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006355//GO:0006810//GO:0006614 regulation of transcription, DNA-templated//transport//SRP-dependent cotranslational protein targeting to membrane GO:0016887//GO:0003676//GO:0005525//GO:0008134//GO:0043531//GO:0016787//GO:0003677//GO:0004386//GO:0005524 ATPase activity//nucleic acid binding//GTP binding//transcription factor binding//ADP binding//hydrolase activity//DNA binding//helicase activity//ATP binding GO:0005667 transcription factor complex KOG0920 ATP-dependent RNA helicase A Cluster-8309.22460 BF_2 54.78 0.67 3689 642932116 XP_008196861.1 1494 1.4e-162 PREDICTED: ATP-dependent RNA helicase DHX36 [Tribolium castaneum] -- -- -- -- -- K14442 DHX36, RHAU ATP-dependent RNA helicase DHX36 http://www.genome.jp/dbget-bin/www_bget?ko:K14442 Q8VHK9 1096 8.0e-118 ATP-dependent RNA helicase DHX36 OS=Mus musculus GN=Dhx36 PE=1 SV=2 PF00005//PF02562//PF01637//PF04851//PF00270//PF00931//PF00910//PF04408//PF05279//PF00158//PF00004//PF00437//PF00448 ABC transporter//PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//NB-ARC domain//RNA helicase//Helicase associated domain (HA2)//Aspartyl beta-hydroxylase N-terminal region//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain GO:0006614//GO:0006810//GO:0006355 SRP-dependent cotranslational protein targeting to membrane//transport//regulation of transcription, DNA-templated GO:0016787//GO:0005524//GO:0008134//GO:0016887//GO:0003677//GO:0003723//GO:0004386//GO:0043531//GO:0003676//GO:0005525//GO:0003724 hydrolase activity//ATP binding//transcription factor binding//ATPase activity//DNA binding//RNA binding//helicase activity//ADP binding//nucleic acid binding//GTP binding//RNA helicase activity GO:0005667//GO:0016020 transcription factor complex//membrane KOG0920 ATP-dependent RNA helicase A Cluster-8309.22465 BF_2 4.00 3.31 330 478252125 ENN72556.1 206 2.8e-14 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22466 BF_2 16.00 5.58 406 780705867 XP_011703203.1 222 4.8e-16 PREDICTED: fatty acid synthase [Wasmannia auropunctata]>gi|780705871|ref|XP_011703204.1| PREDICTED: fatty acid synthase [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- P12785 143 2.8e-08 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22467 BF_2 1005.98 26.89 1852 642911995 XP_969577.2 780 4.3e-80 PREDICTED: translocon-associated protein subunit beta [Tribolium castaneum] -- -- -- -- -- K13250 SSR2 translocon-associated protein subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K13250 Q9CPW5 475 4.1e-46 Translocon-associated protein subunit beta OS=Mus musculus GN=Ssr2 PE=1 SV=1 PF06481//PF11857 COX Aromatic Rich Motif//Domain of unknown function (DUF3377) GO:0055114//GO:0022900//GO:0006118 oxidation-reduction process//electron transport chain//obsolete electron transport GO:0004222//GO:0008827 metalloendopeptidase activity//cytochrome o ubiquinol oxidase activity GO:0009319//GO:0016021 cytochrome o ubiquinol oxidase complex//integral component of membrane KOG3317 Translocon-associated complex TRAP, beta subunit Cluster-8309.22469 BF_2 11.00 0.46 1277 755874668 XP_011292454.1 190 7.7e-12 PREDICTED: uncharacterized protein LOC101891872 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22470 BF_2 33.00 12.86 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.22471 BF_2 3.00 11.57 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22472 BF_2 145.74 1.36 4762 123507472 XP_001329422.1 1084 6.2e-115 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121912377|gb|EAY17199.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 881 8.9e-93 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00686//PF00910//PF03488//PF13606//PF00023 Starch binding domain//RNA helicase//Nematode insulin-related peptide beta type//Ankyrin repeat//Ankyrin repeat GO:0007165 signal transduction GO:0005179//GO:2001070//GO:0003724//GO:0005515//GO:0003723 hormone activity//starch binding//RNA helicase activity//protein binding//RNA binding GO:0005576 extracellular region -- -- Cluster-8309.22473 BF_2 53.41 0.37 6390 642917129 XP_008191127.1 2575 1.1e-287 PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917131|ref|XP_008191128.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917133|ref|XP_008191129.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|270003487|gb|EEZ99934.1| hypothetical protein TcasGA2_TC002730 [Tribolium castaneum] 642917132 XM_008192907.1 839 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X3, mRNA -- -- -- -- Q6P9K8 396 2.1e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22476 BF_2 549.71 6.32 3924 642917135 XP_008191130.1 2261 1.7e-251 PREDICTED: caskin-1 isoform X2 [Tribolium castaneum]>gi|642917145|ref|XP_008191135.1| PREDICTED: caskin-1 isoform X2 [Tribolium castaneum] 642917136 XM_008192909.1 808 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X5, mRNA -- -- -- -- Q6P9K8 396 1.3e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22477 BF_2 252.96 2.82 4037 642917137 XP_008191131.1 2292 4.4e-255 PREDICTED: caskin-1 isoform X3 [Tribolium castaneum] 642917136 XM_008192909.1 810 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X5, mRNA -- -- -- -- Q6P9K8 396 1.3e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22478 BF_2 141.37 1.36 4631 642917129 XP_008191127.1 2575 7.8e-288 PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917131|ref|XP_008191128.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|642917133|ref|XP_008191129.1| PREDICTED: caskin-1 isoform X1 [Tribolium castaneum]>gi|270003487|gb|EEZ99934.1| hypothetical protein TcasGA2_TC002730 [Tribolium castaneum] 642917132 XM_008192907.1 839 0 PREDICTED: Tribolium castaneum caskin-1 (LOC659574), transcript variant X3, mRNA -- -- -- -- Q6P9K8 396 1.5e-36 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22480 BF_2 4.29 0.47 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22482 BF_2 481.00 4.69 4576 642926401 XP_008191947.1 3150 0.0e+00 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 635 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 1612 1.5e-177 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF03846//PF00104//PF00105 Cell division inhibitor SulA//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0009432//GO:0043401//GO:0051782//GO:0006355//GO:0007165 SOS response//steroid hormone mediated signaling pathway//negative regulation of cell division//regulation of transcription, DNA-templated//signal transduction GO:0043565//GO:0008270//GO:0046872//GO:0003700//GO:0003707 sequence-specific DNA binding//zinc ion binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//steroid hormone receptor activity GO:0005634//GO:0009276//GO:0005667 nucleus//Gram-negative-bacterium-type cell wall//transcription factor complex -- -- Cluster-8309.22484 BF_2 13.11 0.95 863 478249755 ENN70263.1 495 2.2e-47 hypothetical protein YQE_13046, partial [Dendroctonus ponderosae] -- -- -- -- -- K06695 PSMC3IP 26S proteasome regulatory subunit, ATPase 3, interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K06695 Q63ZL2 310 2.6e-27 Homologous-pairing protein 2 homolog OS=Xenopus laevis GN=psmc3ip PE=2 SV=1 PF08702//PF02601//PF10186//PF03965//PF06156 Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Vacuolar sorting 38 and autophagy-related subunit 14//Penicillinase repressor//Protein of unknown function (DUF972) GO:0051258//GO:0007165//GO:0006308//GO:0010508//GO:0045892//GO:0030168//GO:0006260 protein polymerization//signal transduction//DNA catabolic process//positive regulation of autophagy//negative regulation of transcription, DNA-templated//platelet activation//DNA replication GO:0008855//GO:0003677//GO:0030674//GO:0005102 exodeoxyribonuclease VII activity//DNA binding//protein binding, bridging//receptor binding GO:0005577//GO:0009318 fibrinogen complex//exodeoxyribonuclease VII complex KOG4603 TBP-1 interacting protein Cluster-8309.22485 BF_2 2.98 0.59 499 478256535 ENN76719.1 422 3.8e-39 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86V71 265 2.5e-22 Zinc finger protein 429 OS=Homo sapiens GN=ZNF429 PE=2 SV=2 PF02892//PF00412//PF13912//PF00130//PF13465//PF00096 BED zinc finger//LIM domain//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556 intracellular signal transduction GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.22489 BF_2 298.96 4.75 2919 478262421 ENN81092.1 670 3.9e-67 hypothetical protein YQE_02460, partial [Dendroctonus ponderosae]>gi|546673642|gb|ERL85206.1| hypothetical protein D910_02627 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05261//PF05485 TraM protein, DNA-binding//THAP domain GO:0000746 conjugation GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.22492 BF_2 778.00 8.88 3951 91088785 XP_967679.1 5125 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 1A [Tribolium castaneum]>gi|270011628|gb|EFA08076.1| hypothetical protein TcasGA2_TC005672 [Tribolium castaneum] 700253021 KM397468.1 42 8.05629e-10 Dioscorea oppositifolia structural maintenance of chromosomes protein 1 mRNA, partial cds K06636 SMC1 structural maintenance of chromosome 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06636 Q9CU62 2985 0.0e+00 Structural maintenance of chromosomes protein 1A OS=Mus musculus GN=Smc1a PE=1 SV=4 PF06470//PF13304//PF02984//PF04513 SMC proteins Flexible Hinge Domain//AAA domain, putative AbiEii toxin, Type IV TA system//Cyclin, C-terminal domain//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0030261//GO:0007062//GO:0006310//GO:0006281//GO:0051276 chromosome condensation//sister chromatid cohesion//DNA recombination//DNA repair//chromosome organization GO:0005198//GO:0005515//GO:0005524 structural molecule activity//protein binding//ATP binding GO:0005694//GO:0019031//GO:0005634//GO:0019028 chromosome//viral envelope//nucleus//viral capsid KOG0018 Structural maintenance of chromosome protein 1 (sister chromatid cohesion complex Cohesin, subunit SMC1) Cluster-8309.22494 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22495 BF_2 465.09 4.55 4560 91085249 XP_973267.1 1086 3.5e-115 PREDICTED: thioredoxin-related transmembrane protein 2 homolog [Tribolium castaneum]>gi|270009096|gb|EFA05544.1| hypothetical protein TcasGA2_TC015732 [Tribolium castaneum] 815899095 XM_012394754.1 156 3.95071e-73 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 3.2e-92 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00085//PF02144//PF00149//PF04139//PF04005 Thioredoxin//Repair protein Rad1/Rec1/Rad17//Calcineurin-like phosphoesterase//Rad9//Hus1-like protein GO:0000077//GO:0006281//GO:0045454 DNA damage checkpoint//DNA repair//cell redox homeostasis GO:0016787 hydrolase activity GO:0005634//GO:0030896 nucleus//checkpoint clamp complex KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.22497 BF_2 27.00 1.34 1130 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22502 BF_2 56.81 0.90 2920 642910499 XP_008200240.1 1303 1.5e-140 PREDICTED: G protein alpha i subunit [Tribolium castaneum]>gi|270014387|gb|EFA10835.1| hypothetical protein TcasGA2_TC001612 [Tribolium castaneum] 769853321 XM_011639851.1 168 5.37507e-80 PREDICTED: Pogonomyrmex barbatus guanine nucleotide-binding protein G(i) subunit alpha (LOC105427877), mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P20353 1166 4.9e-126 G protein alpha i subunit OS=Drosophila melanogaster GN=Galphai PE=1 SV=2 PF00503//PF00025 G-protein alpha subunit//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0031683//GO:0004871//GO:0019001//GO:0003924 GTP binding//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding//GTPase activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.22503 BF_2 29.25 0.66 2130 91089077 XP_971296.1 436 3.8e-40 PREDICTED: density-regulated protein [Tribolium castaneum]>gi|270012410|gb|EFA08858.1| hypothetical protein TcasGA2_TC006559 [Tribolium castaneum] 389609388 AK401684.1 122 1.45535e-54 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 365 2.7e-33 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.22504 BF_2 87.00 1.20 3313 91090776 XP_969654.1 4098 0.0e+00 PREDICTED: glutamate [NMDA] receptor subunit 1 [Tribolium castaneum]>gi|270013267|gb|EFA09715.1| hypothetical protein TcasGA2_TC011848 [Tribolium castaneum] 516282937 KC814695.1 597 0 Apis cerana cerana NMDA receptor 1 (Nmdar1) mRNA, complete cds K05208 GRIN1 glutamate receptor ionotropic, NMDA 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05208 B3LZ39 3202 0.0e+00 Glutamate [NMDA] receptor subunit 1 OS=Drosophila ananassae GN=Nmdar1 PE=3 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0035235//GO:0006811//GO:0007165//GO:0007268 ionotropic glutamate receptor signaling pathway//ion transport//signal transduction//synaptic transmission GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0030054//GO:0016020//GO:0045211//GO:0016021//GO:0005886 cell junction//membrane//postsynaptic membrane//integral component of membrane//plasma membrane KOG4440 NMDA selective glutamate-gated ion channel receptor subunit GRIN1 Cluster-8309.22506 BF_2 49.25 0.65 3434 642933271 XP_008197352.1 668 7.8e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933272 XM_961737.3 231 6.02706e-115 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X2, mRNA -- -- -- -- Q65Z95 602 1.4e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.22508 BF_2 123.11 2.20 2630 642933271 XP_008197352.1 671 2.7e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933270 XM_008199130.1 229 5.95593e-114 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X1, mRNA -- -- -- -- Q65Z95 602 1.1e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.22509 BF_2 34.35 0.45 3475 642933271 XP_008197352.1 668 7.8e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933270 XM_008199130.1 229 7.89057e-114 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X1, mRNA -- -- -- -- Q65Z95 602 1.5e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.22511 BF_2 188.22 4.30 2117 478260638 ENN80341.1 1309 2.2e-141 hypothetical protein YQE_03333, partial [Dendroctonus ponderosae]>gi|546685233|gb|ERL94760.1| hypothetical protein D910_12034 [Dendroctonus ponderosae] -- -- -- -- -- K16723 STG M-phase inducer phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16723 P20483 654 8.3e-67 M-phase inducer phosphatase OS=Drosophila melanogaster GN=stg PE=1 SV=2 PF16093//PF00598 Proteasome assembly chaperone 4//Influenza Matrix protein (M1) GO:0043248 proteasome assembly GO:0005198//GO:0003723 structural molecule activity//RNA binding -- -- KOG3772 M-phase inducer phosphatase Cluster-8309.22512 BF_2 2.00 0.33 540 270005481 EFA01929.1 205 5.9e-14 hypothetical protein TcasGA2_TC007543 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 168 4.7e-11 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.22514 BF_2 54.16 13.08 460 91078888 XP_973143.1 409 1.1e-37 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 O55173 294 9.9e-26 3-phosphoinositide-dependent protein kinase 1 OS=Rattus norvegicus GN=Pdpk1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.22516 BF_2 1.00 0.55 359 260802021 XP_002595892.1 151 7.2e-08 hypothetical protein BRAFLDRAFT_232236 [Branchiostoma floridae]>gi|229281143|gb|EEN51904.1| hypothetical protein BRAFLDRAFT_232236 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05495//PF00096//PF13465 CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.22519 BF_2 302.85 5.82 2464 546671832 ERL83974.1 934 8.0e-98 hypothetical protein D910_01284 [Dendroctonus ponderosae]>gi|546675381|gb|ERL86589.1| hypothetical protein D910_03996 [Dendroctonus ponderosae]>gi|546677899|gb|ERL88647.1| hypothetical protein D910_06031 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q62283 386 1.1e-35 Tetraspanin-7 OS=Mus musculus GN=Tspan7 PE=2 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22521 BF_2 2.00 0.55 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22522 BF_2 52.47 0.33 7033 642925855 XP_008190573.1 1955 9.2e-216 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K06171 NCSTN nicastrin http://www.genome.jp/dbget-bin/www_bget?ko:K06171 Q9VC27 1091 5.8e-117 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF15220//PF05450//PF00328//PF03089 Hypoxia-inducible lipid droplet-associated//Nicastrin//Histidine phosphatase superfamily (branch 2)//Recombination activating protein 2 GO:0016485//GO:0019497//GO:0006771//GO:0006310//GO:0008284//GO:0001819//GO:0010884 protein processing//hexachlorocyclohexane metabolic process//riboflavin metabolic process//DNA recombination//positive regulation of cell proliferation//positive regulation of cytokine production//positive regulation of lipid storage GO:0003677//GO:0003993 DNA binding//acid phosphatase activity GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.22536 BF_2 5.00 0.73 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22541 BF_2 3.00 0.31 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22542 BF_2 90.61 0.73 5492 270007679 EFA04127.1 2228 1.6e-247 hypothetical protein TcasGA2_TC014370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH60 563 7.6e-56 Golgi-associated PDZ and coiled-coil motif-containing protein OS=Mus musculus GN=Gopc PE=1 SV=1 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22543 BF_2 104.00 6.04 1008 91085237 XP_972967.1 1029 3.1e-109 PREDICTED: NAD-dependent protein deacetylase Sirt4 [Tribolium castaneum] -- -- -- -- -- K11414 SIRT4, SIR2L4 NAD-dependent deacetylase sirtuin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11414 Q8IRR5 860 5.1e-91 NAD-dependent protein deacylase Sirt4 OS=Drosophila melanogaster GN=Sirt4 PE=2 SV=2 PF02146//PF01363//PF16671//PF05191//PF01428 Sir2 family//FYVE zinc finger//Actin cross-linking domain//Adenylate kinase, active site lid//AN1-like Zinc finger GO:0090527//GO:0006144//GO:0046034 actin filament reorganization//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0004017//GO:0046872//GO:0070403 zinc ion binding//adenylate kinase activity//metal ion binding//NAD+ binding -- -- KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.22544 BF_2 4.00 0.65 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22549 BF_2 195.48 3.13 2902 189239090 XP_968540.2 1200 1.3e-128 PREDICTED: cystathionine beta-synthase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01697 E4.2.1.22, CBS cystathionine beta-synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01697 P32232 829 5.8e-87 Cystathionine beta-synthase OS=Rattus norvegicus GN=Cbs PE=1 SV=3 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG1252 Cystathionine beta-synthase and related enzymes Cluster-8309.2255 BF_2 151.00 2.25 3099 91089471 XP_968843.1 1815 7.0e-200 PREDICTED: ankyrin repeat domain-containing protein 27 [Tribolium castaneum]>gi|270011402|gb|EFA07850.1| hypothetical protein TcasGA2_TC005420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMR0 942 4.9e-100 Ankyrin repeat domain-containing protein 27 OS=Mus musculus GN=Ankrd27 PE=1 SV=2 PF00023//PF13606//PF02260 Ankyrin repeat//Ankyrin repeat//FATC domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22550 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22551 BF_2 4.00 0.35 770 270015484 EFA11932.1 424 3.4e-39 hypothetical protein TcasGA2_TC012885 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22553 BF_2 64.70 1.32 2342 642925135 XP_008194182.1 316 3.5e-26 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22554 BF_2 14.52 0.47 1582 91087971 XP_973164.1 388 1.0e-34 PREDICTED: tektin-4 [Tribolium castaneum]>gi|270011906|gb|EFA08354.1| hypothetical protein TcasGA2_TC005997 [Tribolium castaneum] -- -- -- -- -- K18631 TEKT4 tektin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K18631 -- -- -- -- PF09239//PF04098 Topoisomerase VI B subunit, transducer//Rad52/22 family double-strand break repair protein GO:0006310//GO:0006265//GO:0006281 DNA recombination//DNA topological change//DNA repair GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity -- -- -- -- Cluster-8309.22555 BF_2 7.77 0.31 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22559 BF_2 155.41 1.52 4551 820239016 BAR72977.1 1901 1.1e-209 cytochrome P450 15A1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q6R7M4 1374 5.8e-150 Methyl farnesoate epoxidase OS=Diploptera punctata GN=CYP15A1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.22560 BF_2 55.00 11.98 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05793 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0032968//GO:0006367 positive regulation of transcription elongation from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.22561 BF_2 164.06 9.65 998 91085583 XP_968374.1 649 3.6e-65 PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|642926992|ref|XP_008195095.1| PREDICTED: 26S proteasome non-ATPase regulatory subunit 9 [Tribolium castaneum]>gi|270010071|gb|EFA06519.1| hypothetical protein TcasGA2_TC009422 [Tribolium castaneum] -- -- -- -- -- K06693 PSMD9 26S proteasome non-ATPase regulatory subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06693 Q9WTV5 456 3.5e-44 26S proteasome non-ATPase regulatory subunit 9 OS=Rattus norvegicus GN=Psmd9 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3129 26S proteasome regulatory complex, subunit PSMD9 Cluster-8309.22563 BF_2 14.00 1.44 694 158562474 ABW74143.1 323 1.6e-27 cuticular protein Ld-CP3 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F2 283 2.8e-24 Endocuticle structural glycoprotein SgAbd-8 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.22568 BF_2 29.11 1.25 1261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22572 BF_2 15.69 2.12 596 91094273 XP_970483.1 529 1.8e-51 PREDICTED: ethylmalonyl-CoA decarboxylase [Tribolium castaneum]>gi|270014393|gb|EFA10841.1| hypothetical protein TcasGA2_TC001618 [Tribolium castaneum] -- -- -- -- -- K18426 ECHDC1 ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18426 F1NB38 339 7.8e-31 Ethylmalonyl-CoA decarboxylase OS=Gallus gallus GN=ECHDC1 PE=3 SV=2 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.22573 BF_2 454.69 24.42 1066 91094273 XP_970483.1 670 1.4e-67 PREDICTED: ethylmalonyl-CoA decarboxylase [Tribolium castaneum]>gi|270014393|gb|EFA10841.1| hypothetical protein TcasGA2_TC001618 [Tribolium castaneum] -- -- -- -- -- K18426 ECHDC1 ethylmalonyl-CoA/methylmalonyl-CoA decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K18426 F1NB38 394 5.9e-37 Ethylmalonyl-CoA decarboxylase OS=Gallus gallus GN=ECHDC1 PE=3 SV=2 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0003824//GO:0016836 catalytic activity//hydro-lyase activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.22574 BF_2 247.67 8.06 1573 91078380 XP_974219.1 194 3.3e-12 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145//PF03310//PF02176 Seven in absentia protein family//Caulimovirus DNA-binding protein//TRAF-type zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0003677 zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.22580 BF_2 338.00 17.88 1078 91095293 XP_967766.1 706 9.5e-72 PREDICTED: calcyclin-binding protein [Tribolium castaneum]>gi|270017125|gb|EFA13571.1| hypothetical protein TcasGA2_TC010306 [Tribolium castaneum] 209881974 XM_002142389.1 48 9.93104e-14 Cryptosporidium muris RN66 CS domain-containing protein, mRNA K04507 CACYBP, SIP calcyclin binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04507 Q6AYK6 458 2.2e-44 Calcyclin-binding protein OS=Rattus norvegicus GN=Cacybp PE=1 SV=1 PF00831 Ribosomal L29 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3260 Calcyclin-binding protein CacyBP Cluster-8309.22581 BF_2 419.60 4.27 4402 270013073 EFA09521.1 1113 2.5e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.1e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF01674//PF00069//PF07714 Lipase (class 2)//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016787//GO:0005524 protein kinase activity//hydrolase activity//ATP binding -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.22582 BF_2 164.83 2.39 3167 260810939 XP_002600180.1 647 1.9e-64 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NN14 484 6.4e-47 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.22583 BF_2 228.48 2.14 4747 641665029 XP_008183228.1 514 7.7e-49 PREDICTED: zinc finger protein 600-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 486 5.6e-47 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00569//PF00096//PF07776//PF07975//PF13465//PF01328//PF13912//PF02892 Zinc finger, ZZ type//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//TFIIH C1-like domain//Zinc-finger double domain//Peroxidase, family 2//C2H2-type zinc finger//BED zinc finger GO:0006979//GO:0006281//GO:0006804 response to oxidative stress//DNA repair//obsolete peroxidase reaction GO:0003677//GO:0046872//GO:0004601//GO:0008270 DNA binding//metal ion binding//peroxidase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.22585 BF_2 69.75 1.03 3118 478255523 ENN75740.1 623 1.2e-61 hypothetical protein YQE_07700, partial [Dendroctonus ponderosae]>gi|546675929|gb|ERL87029.1| hypothetical protein D910_04431 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CR22 151 2.6e-08 Transmembrane protein 42 OS=Mus musculus GN=Tmem42 PE=2 SV=1 PF06974//PF00893//PF01146//PF00892 Protein of unknown function (DUF1298)//Small Multidrug Resistance protein//Caveolin//EamA-like transporter family GO:0042967//GO:0046486//GO:0070836 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process//caveola assembly GO:0004144 diacylglycerol O-acyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.22586 BF_2 27.16 0.57 2271 478255523 ENN75740.1 623 8.5e-62 hypothetical protein YQE_07700, partial [Dendroctonus ponderosae]>gi|546675929|gb|ERL87029.1| hypothetical protein D910_04431 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06974 Protein of unknown function (DUF1298) GO:0042967//GO:0046486 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.22588 BF_2 28.82 0.44 3035 642937493 XP_008198862.1 261 1.1e-19 PREDICTED: protein tramtrack, beta isoform-like isoform X23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09055 Nickel-containing superoxide dismutase GO:0006801 superoxide metabolic process GO:0004784//GO:0016151//GO:0016209 superoxide dismutase activity//nickel cation binding//antioxidant activity -- -- -- -- Cluster-8309.22591 BF_2 51.60 0.67 3496 642932987 XP_008197217.1 808 4.6e-83 PREDICTED: uncharacterized protein LOC103314091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497//PF09618//PF07074 Destabilase//CRISPR-associated protein (Cas_Csy4)//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0043571//GO:0006613//GO:0005975 maintenance of CRISPR repeat elements//cotranslational protein targeting to membrane//carbohydrate metabolic process GO:0004519//GO:0003796 endonuclease activity//lysozyme activity GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex -- -- Cluster-8309.22596 BF_2 202.10 2.02 4464 546680010 ERL90372.1 1094 4.0e-116 hypothetical protein D910_07721 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6VMQ6 269 7.7e-22 Activating transcription factor 7-interacting protein 1 OS=Homo sapiens GN=ATF7IP PE=1 SV=3 PF17060//PF16794//PF06156 Monopolar spindle protein 2//Fibronectin-III type domain//Protein of unknown function (DUF972) GO:0030474//GO:0071988//GO:0006260 spindle pole body duplication//protein localization to spindle pole body//DNA replication GO:0005515 protein binding -- -- -- -- Cluster-8309.22597 BF_2 101.00 4.45 1237 91078792 XP_969832.1 1284 1.0e-138 PREDICTED: probable ribosome production factor 1 [Tribolium castaneum]>gi|270004111|gb|EFA00559.1| hypothetical protein TcasGA2_TC003427 [Tribolium castaneum] 766930850 XM_011499278.1 140 8.23274e-65 PREDICTED: Ceratosolen solmsi marchali probable ribosome production factor 1 (LOC105361956), mRNA K14846 RPF1 ribosome production factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14846 Q9VKB4 966 3.2e-103 Probable ribosome production factor 1 OS=Drosophila melanogaster GN=CG6712 PE=2 SV=1 PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- KOG2780 Ribosome biogenesis protein RPF1, contains IMP4 domain Cluster-8309.22601 BF_2 41.25 0.52 3577 91090906 XP_973803.1 1059 3.7e-112 PREDICTED: ras-related protein Rab-37-like isoform X2 [Tribolium castaneum] 620970185 XM_001514705.3 39 3.39016e-08 PREDICTED: Ornithorhynchus anatinus ras-related protein Rab-39B (LOC100084248), mRNA K07914 RAB37 Ras-related protein Rab-37 http://www.genome.jp/dbget-bin/www_bget?ko:K07914 Q9VP48 740 1.5e-76 Ras-related protein Rab-26 OS=Drosophila melanogaster GN=Rab26 PE=2 SV=2 PF00071//PF02421//PF04670//PF00025//PF08477//PF03193//PF01926 Ras family//Ferrous iron transport protein B//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005525//GO:0003924 ferrous iron transmembrane transporter activity//GTP binding//GTPase activity GO:0016021 integral component of membrane KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.22602 BF_2 270.64 9.21 1516 642910788 XP_008193411.1 458 7.7e-43 PREDICTED: uncharacterized protein LOC658122 isoform X2 [Tribolium castaneum]>gi|270015037|gb|EFA11485.1| hypothetical protein TcasGA2_TC014197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22606 BF_2 8.34 0.58 893 546685019 ERL94584.1 166 3.3e-09 hypothetical protein D910_11861 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22607 BF_2 36.00 0.53 3113 546683517 ERL93319.1 2225 2.0e-247 hypothetical protein D910_10613 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46089 253 3.8e-20 Protein MMS22-like OS=Drosophila melanogaster GN=CG14803 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22610 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22611 BF_2 41.74 1.75 1284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22613 BF_2 96.72 1.47 3047 642937115 XP_008198698.1 1875 7.5e-207 PREDICTED: uncharacterized protein LOC103314418 [Tribolium castaneum]>gi|270000875|gb|EEZ97322.1| hypothetical protein TcasGA2_TC011133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00004//PF00580//PF07088 ATPase family associated with various cellular activities (AAA)//UvrD/REP helicase N-terminal domain//GvpD gas vesicle protein -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.22615 BF_2 42.86 1.23 1749 642937115 XP_008198698.1 719 4.8e-73 PREDICTED: uncharacterized protein LOC103314418 [Tribolium castaneum]>gi|270000875|gb|EEZ97322.1| hypothetical protein TcasGA2_TC011133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08408 DNA polymerase family B viral insert GO:0006260 DNA replication GO:0003887 DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.22621 BF_2 285.34 7.66 1845 332373514 AEE61898.1 557 3.1e-54 unknown [Dendroctonus ponderosae] 642934342 XM_008200388.1 93 1.6614e-38 PREDICTED: Tribolium castaneum uncharacterized LOC103314398 (LOC103314398), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22623 BF_2 5.00 1.58 419 390362249 XP_001190749.2 290 6.4e-24 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 227 5.3e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.22624 BF_2 8.00 0.72 753 321467243 EFX78234.1 260 3.5e-20 hypothetical protein DAPPUDRAFT_246627 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22625 BF_2 41.00 0.44 4195 390362249 XP_001190749.2 1542 4.3e-168 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q505D1 996 3.6e-106 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22628 BF_2 128.57 24.12 510 471180443 AGI05172.1 382 1.7e-34 chemosensory protein 2 [Dendroctonus ponderosae]>gi|478257979|gb|ENN78117.1| hypothetical protein YQE_05271, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 270 6.7e-23 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22630 BF_2 259.16 1.77 6397 642921412 XP_008192854.1 1114 2.8e-118 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.44674e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 791 3.2e-82 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.22637 BF_2 111.16 1.06 4673 390362249 XP_001190749.2 755 8.6e-77 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 713 2.6e-73 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.22638 BF_2 10.24 0.49 1166 270008898 EFA05346.1 765 1.5e-78 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 435 1.1e-41 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF01920//PF13851//PF07851//PF04632//PF01297//PF00038//PF02601//PF04513//PF17078//PF04728//PF07926//PF00170//PF16740//PF06156//PF02148//PF03255 Prefoldin subunit//Growth-arrest specific micro-tubule binding//TMPIT-like protein//Fusaric acid resistance protein family//Zinc-uptake complex component A periplasmic//Intermediate filament protein//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//SWI5-dependent HO expression protein 3//Lipoprotein leucine-zipper//TPR/MLP1/MLP2-like protein//bZIP transcription factor//Spindle and kinetochore-associated protein 2//Protein of unknown function (DUF972)//Zn-finger in ubiquitin-hydrolases and other protein//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GO:0006260//GO:0006090//GO:0051301//GO:0006606//GO:0048309//GO:0048870//GO:0051028//GO:0006633//GO:0006810//GO:0007059//GO:0031110//GO:0007067//GO:0006355//GO:0000090//GO:0006457//GO:0030001//GO:0006308 DNA replication//pyruvate metabolic process//cell division//protein import into nucleus//endoplasmic reticulum inheritance//cell motility//mRNA transport//fatty acid biosynthetic process//transport//chromosome segregation//regulation of microtubule polymerization or depolymerization//mitotic nuclear division//regulation of transcription, DNA-templated//mitotic anaphase//protein folding//metal ion transport//DNA catabolic process GO:0003700//GO:0051082//GO:0046872//GO:0003989//GO:0005198//GO:0008270//GO:0043565//GO:0008855//GO:0008017 transcription factor activity, sequence-specific DNA binding//unfolded protein binding//metal ion binding//acetyl-CoA carboxylase activity//structural molecule activity//zinc ion binding//sequence-specific DNA binding//exodeoxyribonuclease VII activity//microtubule binding GO:0045298//GO:0005882//GO:0019028//GO:0016272//GO:0009318//GO:0005667//GO:0031514//GO:0016021//GO:0009317//GO:0005876//GO:0019031//GO:0019867//GO:0005886//GO:0000940 tubulin complex//intermediate filament//viral capsid//prefoldin complex//exodeoxyribonuclease VII complex//transcription factor complex//motile cilium//integral component of membrane//acetyl-CoA carboxylase complex//spindle microtubule//viral envelope//outer membrane//plasma membrane//condensed chromosome outer kinetochore KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.22642 BF_2 544.00 14.47 1860 91078362 XP_973932.1 1561 1.2e-170 PREDICTED: adenosine deaminase CECR1 [Tribolium castaneum]>gi|270003977|gb|EFA00425.1| hypothetical protein TcasGA2_TC003279 [Tribolium castaneum] -- -- -- -- -- K19572 CECR1, ADA2 adenosine deaminase CECR1 http://www.genome.jp/dbget-bin/www_bget?ko:K19572 Q2VQV9 1032 1.1e-110 Adenosine deaminase CECR1 OS=Xenopus laevis GN=cecr1 PE=1 SV=1 PF00236//PF08451//PF00962 Glycoprotein hormone//Adenosine/AMP deaminase N-terminal//Adenosine/AMP deaminase GO:0007165 signal transduction GO:0005179//GO:0019239 hormone activity//deaminase activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1097 Adenine deaminase/adenosine deaminase Cluster-8309.22644 BF_2 34.77 0.77 2174 642924686 XP_008194398.1 2011 9.1e-223 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 734 4.5e-76 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF07086//PF00999 Jagunal, ER re-organisation during oogenesis//Sodium/hydrogen exchanger family GO:0006885//GO:0055085//GO:0006812//GO:0007029 regulation of pH//transmembrane transport//cation transport//endoplasmic reticulum organization GO:0015299 solute:proton antiporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3826 Na+/H+ antiporter Cluster-8309.22646 BF_2 145.00 10.78 850 478252717 ENN73112.1 459 3.3e-43 hypothetical protein YQE_10253, partial [Dendroctonus ponderosae]>gi|546673855|gb|ERL85385.1| hypothetical protein D910_02805 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22648 BF_2 15.47 0.32 2288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22649 BF_2 251.09 2.12 5233 642922353 XP_008193121.1 1173 3.3e-125 PREDICTED: male-specific lethal 1 homolog [Tribolium castaneum] -- -- -- -- -- K13163 MSL1 male-specific lethal 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13163 A9JRX0 283 2.1e-23 Male-specific lethal 1-like 1 OS=Danio rerio GN=msl1l1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22651 BF_2 573.73 23.58 1305 642918168 XP_968046.3 1065 2.7e-113 PREDICTED: delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K12663 ECH1 delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K12663 Q62651 776 3.6e-81 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial OS=Rattus norvegicus GN=Ech1 PE=1 SV=2 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1681 Enoyl-CoA isomerase Cluster-8309.22652 BF_2 26.29 0.39 3079 91083715 XP_970185.1 1197 3.2e-128 PREDICTED: RNA-binding protein 45 [Tribolium castaneum]>gi|270007883|gb|EFA04331.1| hypothetical protein TcasGA2_TC014625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUH3 567 1.5e-56 RNA-binding protein 45 OS=Homo sapiens GN=RBM45 PE=1 SV=1 PF16367//PF00076//PF08675//PF08777//PF14552 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain//RNA binding motif//Tautomerase enzyme GO:0006402//GO:0051252//GO:0006725 mRNA catabolic process//regulation of RNA metabolic process//cellular aromatic compound metabolic process GO:0016853//GO:0003723//GO:0046872//GO:0003676//GO:0004535//GO:1901363//GO:0097159 isomerase activity//RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity//heterocyclic compound binding//organic cyclic compound binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.22653 BF_2 95.56 1.25 3475 478250819 ENN71311.1 810 2.7e-83 hypothetical protein YQE_12236, partial [Dendroctonus ponderosae]>gi|546679724|gb|ERL90139.1| hypothetical protein D910_07493 [Dendroctonus ponderosae] -- -- -- -- -- K14775 UTP30, RSL1D1 ribosome biogenesis protein UTP30 http://www.genome.jp/dbget-bin/www_bget?ko:K14775 Q9VLK2 333 2.3e-29 Ribosomal L1 domain-containing protein CG13096 OS=Drosophila melanogaster GN=CG13096 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22656 BF_2 27.30 0.36 3498 642924747 XP_008194424.1 3968 0.0e+00 PREDICTED: tyrosine-protein kinase PR2 isoform X3 [Tribolium castaneum] 462376521 APGK01023661.1 50 2.54422e-14 Dendroctonus ponderosae Seq01023671, whole genome shotgun sequence -- -- -- -- Q9I7F7 1702 4.1e-188 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF14604//PF00018//PF00069//PF07714 Variant SH3 domain//SH3 domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.22658 BF_2 156.01 4.37 1779 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22659 BF_2 558.56 9.19 2831 91090602 XP_972981.1 1139 1.5e-121 PREDICTED: MOB kinase activator-like 4 [Tribolium castaneum]>gi|270013903|gb|EFA10351.1| hypothetical protein TcasGA2_TC012571 [Tribolium castaneum] 820865569 XM_003698745.2 231 4.95751e-115 PREDICTED: Apis florea MOB kinase activator-like 4 (LOC100868901), transcript variant X1, mRNA -- -- -- -- Q7K0E3 1056 2.7e-113 MOB kinase activator-like 4 OS=Drosophila melanogaster GN=Mob4 PE=2 SV=1 PF02060 Slow voltage-gated potassium channel GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0008076//GO:0016020 voltage-gated potassium channel complex//membrane KOG1852 Cell cycle-associated protein Cluster-8309.22661 BF_2 6.00 0.40 918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22663 BF_2 321.49 25.24 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22667 BF_2 6.37 1.91 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22669 BF_2 118.20 1.62 3333 270003223 EEZ99670.1 2222 4.8e-247 hypothetical protein TcasGA2_TC002427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00514//PF11698//PF00651 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//BTB/POZ domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.22670 BF_2 6.00 0.37 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11815 Domain of unknown function (DUF3336) GO:0046486//GO:0006629//GO:0016042 glycerolipid metabolic process//lipid metabolic process//lipid catabolic process GO:0004806 triglyceride lipase activity -- -- -- -- Cluster-8309.22671 BF_2 7.00 0.34 1147 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22673 BF_2 7.85 0.52 914 642910918 XP_008193464.1 251 4.7e-19 PREDICTED: microphthalmia-associated transcription factor isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00284 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit GO:0015979 photosynthesis GO:0046872 metal ion binding GO:0009523//GO:0016021 photosystem II//integral component of membrane -- -- Cluster-8309.22675 BF_2 32.07 0.88 1817 478255961 ENN76162.1 1586 1.5e-173 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 O08812 1018 4.4e-109 Cationic amino acid transporter 3 OS=Rattus norvegicus GN=Slc7a3 PE=2 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.22676 BF_2 11.52 0.97 783 91078608 XP_967155.1 398 3.6e-36 PREDICTED: mitochondrial import inner membrane translocase subunit Tim10 [Tribolium castaneum]>gi|270004056|gb|EFA00504.1| hypothetical protein TcasGA2_TC003366 [Tribolium castaneum] -- -- -- -- -- K17778 TIM10 mitochondrial import inner membrane translocase subunit TIM10 http://www.genome.jp/dbget-bin/www_bget?ko:K17778 Q9W2D6 317 3.6e-28 Mitochondrial import inner membrane translocase subunit Tim10 OS=Drosophila melanogaster GN=Tim10 PE=3 SV=1 -- -- GO:0045039 protein import into mitochondrial inner membrane GO:0046872 metal ion binding GO:0042719//GO:0005743 mitochondrial intermembrane space protein transporter complex//mitochondrial inner membrane KOG3480 Mitochondrial import inner membrane translocase, subunits TIM10/TIM12 Cluster-8309.22678 BF_2 37.00 1.21 1571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00342 Phosphoglucose isomerase GO:0005985//GO:0006094//GO:0006096//GO:0005982//GO:0006098 sucrose metabolic process//gluconeogenesis//glycolytic process//starch metabolic process//pentose-phosphate shunt GO:0004347 glucose-6-phosphate isomerase activity -- -- -- -- Cluster-8309.22679 BF_2 12.21 0.93 839 270006730 EFA03178.1 703 1.7e-71 hypothetical protein TcasGA2_TC013098 [Tribolium castaneum] 768436543 XM_011561462.1 101 2.63969e-43 PREDICTED: Plutella xylostella protein abrupt-like (LOC105390200), transcript variant X3, mRNA -- -- -- -- Q24174 498 4.0e-49 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.22681 BF_2 105.00 1.31 3643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22685 BF_2 464.30 10.49 2139 642911136 XP_008200596.1 1380 1.3e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 6.8e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22689 BF_2 78.50 1.40 2626 642920766 XP_008192551.1 1683 1.2e-184 PREDICTED: translation factor GUF1 homolog, mitochondrial isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0WXB8 1437 1.6e-157 Translation factor GUF1 homolog, mitochondrial OS=Culex quinquefasciatus GN=CPIJ012086 PE=3 SV=1 PF06377//PF03144//PF01386 Adipokinetic hormone//Elongation factor Tu domain 2//Ribosomal L25p family GO:0042254//GO:0007165//GO:0006412 ribosome biogenesis//signal transduction//translation GO:0005525//GO:0003735//GO:0008097//GO:0005179 GTP binding//structural constituent of ribosome//5S rRNA binding//hormone activity GO:0005840 ribosome KOG0462 Elongation factor-type GTP-binding protein Cluster-8309.22690 BF_2 51.92 0.62 3811 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.9e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22692 BF_2 25.45 0.32 3607 270297218 NP_001161918.1 475 2.0e-44 cuticular protein analogous to peritrophins 1-H precursor [Tribolium castaneum]>gi|642929138|ref|XP_008195708.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|642929140|ref|XP_008195709.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|268309014|gb|ACY95473.1| cuticular protein analogous to peritrophins 1-H [Tribolium castaneum]>gi|270010495|gb|EFA06943.1| hypothetical protein TcasGA2_TC009894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03110//PF10717 SBP domain//Occlusion-derived virus envelope protein ODV-E18 -- -- GO:0003677 DNA binding GO:0005634//GO:0019031 nucleus//viral envelope -- -- Cluster-8309.22694 BF_2 51.03 0.69 3366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22695 BF_2 1140.00 15.17 3431 546686193 ERL95573.1 1453 7.3e-158 hypothetical protein D910_12834 [Dendroctonus ponderosae] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 A7SMW7 1249 1.4e-135 L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Nematostella vectensis GN=v1g172254 PE=3 SV=1 PF05834//PF07992//PF01266//PF03435//PF01494//PF06039//PF02254 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//FAD binding domain//Malate:quinone oxidoreductase (Mqo)//TrkA-N domain GO:0006813//GO:0006090//GO:0016117//GO:0006099//GO:0055114 potassium ion transport//pyruvate metabolic process//carotenoid biosynthetic process//tricarboxylic acid cycle//oxidation-reduction process GO:0071949//GO:0016705//GO:0016491//GO:0008924 FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//malate dehydrogenase (quinone) activity -- -- KOG2665 Predicted FAD-dependent oxidoreductase Cluster-8309.22698 BF_2 87.50 0.59 6529 642929489 XP_008195859.1 4610 0.0e+00 PREDICTED: ADAMTS-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82987 811 1.6e-84 ADAMTS-like protein 3 OS=Homo sapiens GN=ADAMTSL3 PE=1 SV=4 PF13895//PF08686 Immunoglobulin domain//PLAC (protease and lacunin) domain -- -- GO:0008233//GO:0005515 peptidase activity//protein binding -- -- KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.22699 BF_2 47.11 2.72 1011 665794141 XP_008544754.1 671 1.0e-67 PREDICTED: pseudouridine-5'-monophosphatase isoform X1 [Microplitis demolitor] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 623 1.5e-63 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 PF12162 STAT1 TAZ2 binding domain -- -- GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.22700 BF_2 136.07 6.16 1211 270000732 EEZ97179.1 935 3.0e-98 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] -- -- -- -- -- K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 464 5.1e-45 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 PF06220//PF00096//PF03153 U1 zinc finger//Zinc finger, C2H2 type//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.22702 BF_2 153.26 0.84 7959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22710 BF_2 390.11 3.94 4424 642922521 XP_008193210.1 2802 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1116 4.6e-120 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF02985//PF00514 HEAT repeat//Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.22711 BF_2 158.09 1.98 3619 642922521 XP_008193210.1 3268 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1353 1.2e-147 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF00514//PF02985 Armadillo/beta-catenin-like repeat//HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.22713 BF_2 175.98 4.17 2052 642911136 XP_008200596.1 1383 5.7e-150 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 6.5e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22714 BF_2 9.31 0.57 968 642911138 XP_971944.3 359 1.5e-31 PREDICTED: mitochondrial folate transporter/carrier isoform X2 [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 212 6.8e-16 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22715 BF_2 173.87 3.70 2254 642911136 XP_008200596.1 1379 1.8e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 7.2e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.22716 BF_2 131.29 10.75 798 189236866 XP_001814181.1 265 9.7e-21 PREDICTED: LIRP [Tribolium castaneum]>gi|270006348|gb|EFA02796.1| insulin-like peptide [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15131 180 2.9e-12 LIRP OS=Locusta migratoria PE=1 SV=2 PF00049//PF03488 Insulin/IGF/Relaxin family//Nematode insulin-related peptide beta type GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.22720 BF_2 404.02 1.60 10854 642926389 XP_008194905.1 4857 0.0e+00 PREDICTED: citron Rho-interacting kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14578 2072 1.6e-230 Citron Rho-interacting kinase OS=Homo sapiens GN=CIT PE=1 SV=2 PF00130//PF13851//PF15367//PF00827//PF00069//PF07714//PF09377//PF00391//PF01326//PF00433 Phorbol esters/diacylglycerol binding domain (C1 domain)//Growth-arrest specific micro-tubule binding//Calcium-binding and spermatid-specific protein 1//Ribosomal L15//Protein kinase domain//Protein tyrosine kinase//SBDS protein C-terminal domain//PEP-utilising enzyme, mobile domain//Pyruvate phosphate dikinase, PEP/pyruvate binding domain//Protein kinase C terminal domain GO:0007283//GO:0042254//GO:0035556//GO:0009069//GO:0006468//GO:0048870//GO:0016310//GO:0006412 spermatogenesis//ribosome biogenesis//intracellular signal transduction//serine family amino acid metabolic process//protein phosphorylation//cell motility//phosphorylation//translation GO:0004674//GO:0016301//GO:0016772//GO:0003735//GO:0005524//GO:0004672//GO:0005509 protein serine/threonine kinase activity//kinase activity//transferase activity, transferring phosphorus-containing groups//structural constituent of ribosome//ATP binding//protein kinase activity//calcium ion binding GO:0005840//GO:0031514 ribosome//motile cilium KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.22723 BF_2 40.06 0.35 5019 478252787 ENN73180.1 1403 6.7e-152 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 5.8e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 PF03083 Sugar efflux transporter for intercellular exchange -- -- -- -- GO:0016021 integral component of membrane KOG4780 Uncharacterized conserved protein Cluster-8309.22724 BF_2 302.00 17.19 1022 270002473 EEZ98920.1 285 5.9e-23 hypothetical protein TcasGA2_TC004539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P24014 203 7.9e-15 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22725 BF_2 127.20 2.84 2162 642924692 XP_008194400.1 1129 1.7e-120 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 257 9.1e-21 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22726 BF_2 535.52 3.76 6249 373159261 AEY63780.1 2481 8.3e-277 ecdysone receptor isoform A [Monochamus alternatus] 373159260 JN616374.1 1422 0 Monochamus alternatus ecdysone receptor isoform A mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1355 1.3e-147 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.22727 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22730 BF_2 6.63 0.48 865 478258155 ENN78293.1 398 4.0e-36 hypothetical protein YQE_05443, partial [Dendroctonus ponderosae]>gi|546682829|gb|ERL92718.1| hypothetical protein D910_10028 [Dendroctonus ponderosae] -- -- -- -- -- K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 314 9.0e-28 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2037 Guanylate-binding protein Cluster-8309.22731 BF_2 315.06 9.55 1667 91090264 XP_970269.1 888 1.2e-92 PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934841|ref|XP_008197832.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934843|ref|XP_008197833.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934845|ref|XP_008197834.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|270013784|gb|EFA10232.1| hypothetical protein TcasGA2_TC012429 [Tribolium castaneum] 780638303 XM_011689036.1 101 5.34984e-43 PREDICTED: Wasmannia auropunctata E3 ubiquitin-protein ligase RNF185-like (LOC105449687), transcript variant X4, mRNA K10666 RNF5 E3 ubiquitin-protein ligase RNF5 http://www.genome.jp/dbget-bin/www_bget?ko:K10666 Q5ZIR9 677 1.4e-69 E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus GN=RNF185 PE=2 SV=1 PF13639//PF00097//PF14634//PF12861//PF12678//PF17123 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//RING-like zinc finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG0823 Predicted E3 ubiquitin ligase Cluster-8309.22734 BF_2 168.12 2.50 3096 642917468 XP_008191214.1 2797 0.0e+00 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X6 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 962 2.3e-102 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00788//PF00617 Ras association (RalGDS/AF-6) domain//RasGEF domain GO:0007165//GO:0043087//GO:0007264 signal transduction//regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.22737 BF_2 7.00 3.66 364 270009283 EFA05731.1 265 4.4e-21 cytochrome P450 6BK14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V776 149 5.1e-09 Probable cytochrome P450 317a1 OS=Drosophila melanogaster GN=Cyp317a1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22738 BF_2 6.00 80.21 226 642925882 XP_008190661.1 309 2.2e-26 PREDICTED: probable cytochrome P450 6a17 [Tribolium castaneum] 118789175 XM_001237901.1 34 1.11925e-06 Anopheles gambiae str. PEST AGAP008214-PA (AgaP_AGAP008214) mRNA, partial cds K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V770 243 4.0e-20 Probable cytochrome P450 6a17 OS=Drosophila melanogaster GN=Cyp6a17 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.22739 BF_2 15.00 29.38 286 282847465 NP_001164281.1 200 1.2e-13 cytochrome P450 CYP6BK17 [Tribolium castaneum]>gi|161344971|gb|ABX64450.1| cytochrome P450 CYP6BK17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15681 Lymphocyte activation family X GO:0051249//GO:0006955 regulation of lymphocyte activation//immune response -- -- -- -- -- -- Cluster-8309.22740 BF_2 1679.09 30.78 2569 741829513 AJA91072.1 1444 6.0e-157 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1018 6.2e-109 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.22741 BF_2 1053.37 20.21 2468 741829513 AJA91072.1 1341 5.1e-145 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 925 3.6e-98 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.22742 BF_2 2.00 0.43 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22744 BF_2 64.57 2.92 1211 780089478 XP_011673857.1 462 2.1e-43 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- K08803 DAPK death-associated protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08803 Q4UMH6 363 2.6e-33 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05396//PF08052 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein//PyrBI operon leader peptide GO:0019069//GO:0019856 viral capsid assembly//pyrimidine nucleobase biosynthetic process GO:0005515 protein binding -- -- -- -- Cluster-8309.22745 BF_2 2.00 7.26 263 -- -- -- -- -- 530723032 KC131028.1 199 2.51027e-98 Portunus trituberculatus skeletal muscle actin 2 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22746 BF_2 87.27 0.69 5560 270012402 EFA08850.1 3240 0.0e+00 hypothetical protein TcasGA2_TC006551 [Tribolium castaneum] 642932661 XM_008198715.1 84 5.10488e-33 PREDICTED: Tribolium castaneum inactive rhomboid protein 1 (LOC658816), mRNA -- -- -- -- Q76NQ1 1377 3.2e-150 Inactive rhomboid protein 1 OS=Drosophila melanogaster GN=rho-5 PE=2 SV=1 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2290 Rhomboid family proteins Cluster-8309.22747 BF_2 286.00 10.52 1424 546679385 ERL89860.1 1430 1.4e-155 hypothetical protein D910_07219 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B3NQR5 1277 3.2e-139 Probable cytosolic iron-sulfur protein assembly protein Ciao1 OS=Drosophila erecta GN=Ciao1 PE=3 SV=1 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0645 WD40 repeat protein Cluster-8309.22748 BF_2 40.94 0.44 4188 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22749 BF_2 212.54 4.17 2417 100811805 BAE94685.1 2536 1.3e-283 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 754 2.4e-78 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.22752 BF_2 12.00 2.07 529 817061123 XP_012252151.1 166 1.9e-09 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00165//PF03193 Bacterial regulatory helix-turn-helix proteins, AraC family//Protein of unknown function, DUF258 GO:0006355 regulation of transcription, DNA-templated GO:0005525//GO:0043565//GO:0003924//GO:0003700 GTP binding//sequence-specific DNA binding//GTPase activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.22755 BF_2 306.43 1.96 6835 642917395 XP_008191178.1 2504 2.0e-279 PREDICTED: DNA ligase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2125 7.1e-237 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF04679//PF04675//PF00515//PF13414//PF01331//PF13181//PF13174//PF01068 ATP dependent DNA ligase C terminal region//DNA ligase N terminus//Tetratricopeptide repeat//TPR repeat//mRNA capping enzyme, catalytic domain//Tetratricopeptide repeat//Tetratricopeptide repeat//ATP dependent DNA ligase domain GO:0006281//GO:0006397//GO:0006310//GO:0006370//GO:0006260 DNA repair//mRNA processing//DNA recombination//7-methylguanosine mRNA capping//DNA replication GO:0004484//GO:0005515//GO:0005524//GO:0003677//GO:0003910 mRNA guanylyltransferase activity//protein binding//ATP binding//DNA binding//DNA ligase (ATP) activity -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.22757 BF_2 119.16 0.76 6853 815910998 XP_012241008.1 2504 2.0e-279 PREDICTED: DNA ligase 1 isoform X2 [Bombus impatiens] -- -- -- -- -- K10747 LIG1 DNA ligase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10747 P51892 2120 2.7e-236 DNA ligase 1 OS=Xenopus laevis GN=lig1 PE=2 SV=1 PF13181//PF01068//PF13174//PF00515//PF04675//PF04679//PF13414//PF01331 Tetratricopeptide repeat//ATP dependent DNA ligase domain//Tetratricopeptide repeat//Tetratricopeptide repeat//DNA ligase N terminus//ATP dependent DNA ligase C terminal region//TPR repeat//mRNA capping enzyme, catalytic domain GO:0006370//GO:0006310//GO:0006260//GO:0006281//GO:0006397 7-methylguanosine mRNA capping//DNA recombination//DNA replication//DNA repair//mRNA processing GO:0003910//GO:0005515//GO:0004484//GO:0005524//GO:0003677 DNA ligase (ATP) activity//protein binding//mRNA guanylyltransferase activity//ATP binding//DNA binding -- -- KOG0967 ATP-dependent DNA ligase I Cluster-8309.22759 BF_2 158.98 4.19 1875 642925505 XP_008194578.1 1307 3.4e-141 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 621 4.9e-63 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF06687 SUR7/PalI family -- -- -- -- GO:0005886 plasma membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.2276 BF_2 34.00 2.25 919 321462347 EFX73371.1 879 7.1e-92 hypothetical protein DAPPUDRAFT_231352 [Daphnia pulex] 262401292 FJ774828.1 311 5.30082e-160 Scylla paramamosain ribosomal protein L7Ae mRNA, partial cds K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P46223 798 7.2e-84 60S ribosomal protein L7a OS=Drosophila melanogaster GN=RpL7A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8309.22761 BF_2 1.00 0.44 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04625 DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213 structural constituent of chorion GO:0005576//GO:0042600 extracellular region//chorion -- -- Cluster-8309.22762 BF_2 1.00 2.01 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22763 BF_2 38.00 0.80 2284 768196859 KJH52544.1 185 5.2e-11 c-terminal tandem repeated domain in type 4 procollagen [Dictyocaulus viviparus] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 P27393 171 9.1e-11 Collagen alpha-2(IV) chain OS=Ascaris suum PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.22765 BF_2 159.76 7.24 1210 91081553 XP_975065.1 969 3.4e-102 PREDICTED: RWD domain-containing protein 2A [Tribolium castaneum]>gi|270006181|gb|EFA02629.1| hypothetical protein TcasGA2_TC008349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UIY3 542 4.6e-54 RWD domain-containing protein 2A OS=Homo sapiens GN=RWDD2A PE=1 SV=1 PF05424//PF05773 Duffy binding domain//RWD domain GO:0007165//GO:0009405 signal transduction//pathogenesis GO:0005515//GO:0004872 protein binding//receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.22766 BF_2 21.12 0.41 2429 642934168 XP_008199635.1 1279 7.8e-138 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.7599e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 Q5ZKY2 815 2.0e-85 Ubiquitin-like modifier-activating enzyme ATG7 OS=Gallus gallus GN=ATG7 PE=2 SV=1 PF00899//PF02826//PF02558//PF13241 ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Ketopantoate reductase PanE/ApbA//Putative NAD(P)-binding GO:0055114//GO:0006779//GO:0019354//GO:0015940 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//pantothenate biosynthetic process GO:0008641//GO:0008677//GO:0051287//GO:0043115 small protein activating enzyme activity//2-dehydropantoate 2-reductase activity//NAD binding//precorrin-2 dehydrogenase activity -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.22768 BF_2 2.00 2.53 306 -- -- -- -- -- 543175329 CP001103.3 264 2.19207e-134 Alteromonas macleodii str. 'Deep ecotype', complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22769 BF_2 2.00 0.44 477 -- -- -- -- -- 507148294 NR_103097.1 300 3.46566e-154 Pseudoalteromonas haloplanktis strain TAC125 23S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2277 BF_2 1.00 0.46 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22770 BF_2 112.82 1.04 4808 270013073 EFA09521.1 1113 2.7e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.6e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF07714//PF01674//PF00069 Protein tyrosine kinase//Lipase (class 2)//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0016787//GO:0004672 ATP binding//hydrolase activity//protein kinase activity -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.22771 BF_2 241.38 2.52 4301 642940435 XP_008194234.1 2341 9.8e-261 PREDICTED: rho GTPase-activating protein 26, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMW5 1504 4.6e-165 Rho GTPase-activating protein 26 OS=Gallus gallus GN=ARHGAP26 PE=1 SV=2 PF03114//PF00620//PF01297//PF01956//PF03155 BAR domain//RhoGAP domain//Zinc-uptake complex component A periplasmic//Integral membrane protein DUF106//ALG6, ALG8 glycosyltransferase family GO:0007165//GO:0030001 signal transduction//metal ion transport GO:0046872//GO:0005515//GO:0016758 metal ion binding//protein binding//transferase activity, transferring hexosyl groups GO:0005737//GO:0016020//GO:0005789 cytoplasm//membrane//endoplasmic reticulum membrane KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.22775 BF_2 2.86 0.59 489 642914773 XP_008190345.1 368 6.7e-33 PREDICTED: protein SERAC1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SNQ7 185 4.6e-13 Protein SERAC1 OS=Danio rerio GN=serac1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22778 BF_2 980.53 5.96 7165 91093773 XP_966763.1 2305 2.4e-256 PREDICTED: KAT8 regulatory NSL complex subunit 1 [Tribolium castaneum]>gi|270015922|gb|EFA12370.1| hypothetical protein TcasGA2_TC002076 [Tribolium castaneum] 462418059 APGK01017125.1 89 1.09415e-35 Dendroctonus ponderosae Seq01017135, whole genome shotgun sequence K18400 KANSL1 KAT8 regulatory NSL complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18400 Q80TG1 409 7.2e-38 KAT8 regulatory NSL complex subunit 1 OS=Mus musculus GN=Kansl1 PE=2 SV=1 PF07544//PF06009//PF17064//PF08651 RNA polymerase II transcription mediator complex subunit 9//Laminin Domain II//Sleepless protein//DASH complex subunit Duo1 GO:0032222//GO:0007067//GO:0007155//GO:0006357//GO:0030431//GO:1903818 regulation of synaptic transmission, cholinergic//mitotic nuclear division//cell adhesion//regulation of transcription from RNA polymerase II promoter//sleep//positive regulation of voltage-gated potassium channel activity GO:0001104//GO:0034235 RNA polymerase II transcription cofactor activity//GPI anchor binding GO:0042729//GO:0016592//GO:0072686 DASH complex//mediator complex//mitotic spindle -- -- Cluster-8309.22779 BF_2 77.00 0.97 3621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00435//PF06368 Spectrin repeat//Methylaspartate mutase E chain (MutE) GO:0019670 anaerobic glutamate catabolic process GO:0005515//GO:0050097 protein binding//methylaspartate mutase activity -- -- -- -- Cluster-8309.2278 BF_2 10.00 0.52 1091 390335172 XP_783048.2 1328 7.2e-144 PREDICTED: phosphate carrier protein, mitochondrial [Strongylocentrotus purpuratus] 780165995 XM_777955.4 228 8.72812e-114 PREDICTED: Strongylocentrotus purpuratus phosphate carrier protein, mitochondrial (LOC577743), mRNA K15102 SLC25A3, PHC, PIC solute carrier family 25 (mitochondrial phosphate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15102 Q5R7W2 1273 7.1e-139 Phosphate carrier protein, mitochondrial OS=Pongo abelii GN=SLC25A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0767 Mitochondrial phosphate carrier protein Cluster-8309.22783 BF_2 339.05 9.40 1796 642911711 XP_970705.2 1511 7.2e-165 PREDICTED: solute carrier family 25 member 46-like [Tribolium castaneum]>gi|270014568|gb|EFA11016.1| hypothetical protein TcasGA2_TC004603 [Tribolium castaneum] -- -- -- -- -- K03454 SLC25A46 solute carrier family 25, member 46 http://www.genome.jp/dbget-bin/www_bget?ko:K03454 Q5ZIG3 713 1.0e-73 Solute carrier family 25 member 46 OS=Gallus gallus GN=SLC25A46 PE=2 SV=1 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG2954 Mitochondrial carrier protein Cluster-8309.22787 BF_2 38.00 1.01 1863 -- -- -- -- -- 392303553 JX102586.1 621 0 Scylla paramamosain microsatellite Spm15 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22788 BF_2 313.29 10.68 1514 91092262 XP_967283.1 1627 2.1e-178 PREDICTED: methionine aminopeptidase 1 [Tribolium castaneum]>gi|270001228|gb|EEZ97675.1| hypothetical protein TcasGA2_TC016220 [Tribolium castaneum] 746858202 XM_011061556.1 236 4.36016e-118 PREDICTED: Acromyrmex echinatior methionine aminopeptidase 1 (LOC105149265), transcript variant X2, mRNA K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q4QRK0 1232 5.6e-134 Methionine aminopeptidase 1 OS=Danio rerio GN=metap1 PE=2 SV=2 -- -- GO:0009987//GO:0006508 cellular process//proteolysis GO:0046872//GO:0004177//GO:0008270//GO:0008235 metal ion binding//aminopeptidase activity//zinc ion binding//metalloexopeptidase activity -- -- KOG2738 Putative methionine aminopeptidase Cluster-8309.22790 BF_2 78.00 1.30 2801 91095123 XP_970890.1 610 3.4e-60 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 461 2.6e-44 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.22791 BF_2 4.74 0.98 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22792 BF_2 10.00 9.75 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22796 BF_2 2.35 3.04 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22797 BF_2 14.27 0.80 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22798 BF_2 41.00 0.40 4629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05739//PF05399 SNARE domain//Ectropic viral integration site 2A protein (EVI2A) -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.22800 BF_2 37.90 0.98 1900 304441899 ADM34185.1 476 7.9e-45 myosin light chain [Penaeus monodon] -- -- -- -- -- K12757 MYL12 myosin regulatory light chain 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12757 Q1HPS0 442 2.8e-42 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13499//PF13833//PF13405//PF04625//PF01213//PF01299//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//DEC-1 protein, N-terminal region//Adenylate cyclase associated (CAP) N terminal//Lysosome-associated membrane glycoprotein (Lamp)//EF hand//EF hand GO:0007010//GO:0007304 cytoskeleton organization//chorion-containing eggshell formation GO:0003779//GO:0005213//GO:0005509 actin binding//structural constituent of chorion//calcium ion binding GO:0042600//GO:0016020//GO:0005576 chorion//membrane//extracellular region KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.22801 BF_2 54.20 6.27 649 642913478 XP_008201029.1 580 2.3e-57 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- K00902 E2.7.1.108 dolichol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00902 Q8R2Y3 336 1.9e-30 Dolichol kinase OS=Mus musculus GN=Dolk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2468 Dolichol kinase Cluster-8309.22802 BF_2 10.89 0.37 1516 91094103 XP_967297.1 1386 1.9e-150 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VFT9 926 1.7e-98 Trafficking protein particle complex subunit 13 OS=Xenopus tropicalis GN=trappc13 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.22804 BF_2 4.00 0.53 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22805 BF_2 58.50 1.19 2341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22806 BF_2 176.33 2.93 2801 657592270 XP_008300654.1 354 1.6e-30 PREDICTED: zinc finger protein 345-like isoform X1 [Stegastes partitus] -- -- -- -- -- -- -- -- -- Q8TC21 320 5.9e-28 Zinc finger protein 596 OS=Homo sapiens GN=ZNF596 PE=2 SV=2 PF00096//PF13465//PF07776//PF10426//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//Recombination-activating protein 1 zinc-finger domain//C2H2-type zinc finger -- -- GO:0016788//GO:0008270//GO:0016881//GO:0046872 hydrolase activity, acting on ester bonds//zinc ion binding//acid-amino acid ligase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.22807 BF_2 12.34 0.71 1010 255522809 NP_001157317.1 158 3.1e-08 longitudinals lacking isoform 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 135 6.0e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF01022//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Bacterial regulatory protein, arsR family//BED zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003700//GO:0003677 metal ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.22809 BF_2 83.17 0.94 3979 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 7.94352e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 3.6e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF05834//PF04097 Lycopene cyclase protein//Nup93/Nic96 GO:0006810//GO:0016117 transport//carotenoid biosynthetic process GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22810 BF_2 32.26 1.45 1216 642918646 XP_008200444.1 495 3.2e-47 PREDICTED: uncharacterized aarF domain-containing protein kinase 5 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q80V03 354 2.9e-32 Uncharacterized aarF domain-containing protein kinase 5 OS=Mus musculus GN=Adck5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.22811 BF_2 33.09 0.34 4394 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 8.77957e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 4.0e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF04097 Nup93/Nic96 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22813 BF_2 8.38 0.37 1233 642918646 XP_008200444.1 474 8.7e-45 PREDICTED: uncharacterized aarF domain-containing protein kinase 5 [Tribolium castaneum] -- -- -- -- -- K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 Q80V03 344 4.2e-31 Uncharacterized aarF domain-containing protein kinase 5 OS=Mus musculus GN=Adck5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1235 Predicted unusual protein kinase Cluster-8309.22814 BF_2 463.83 5.04 4138 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 8.26384e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 3.7e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF04097 Nup93/Nic96 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22815 BF_2 42.45 0.45 4194 91082499 XP_972877.1 3022 0.0e+00 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] 642922743 XM_967784.2 69 8.37665e-25 PREDICTED: Tribolium castaneum nuclear pore complex protein Nup93 (LOC661634), mRNA K14309 NUP93, NIC96 nuclear pore complex protein Nup93 http://www.genome.jp/dbget-bin/www_bget?ko:K14309 Q6NX12 1496 3.8e-164 Nuclear pore complex protein Nup93 OS=Xenopus tropicalis GN=nup93 PE=2 SV=1 PF04097 Nup93/Nic96 GO:0006810 transport -- -- GO:0005643 nuclear pore KOG1235 Predicted unusual protein kinase Cluster-8309.22818 BF_2 1.00 1.87 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22822 BF_2 12.00 1.26 687 642912924 XP_008201308.1 247 1.0e-18 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22823 BF_2 167.85 0.80 9051 642912924 XP_008201308.1 4062 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X3 [Tribolium castaneum] 194890784 XM_001977354.1 96 1.77726e-39 Drosophila erecta GG18278 (Dere\GG18278), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q09103 1946 5.4e-216 Eye-specific diacylglycerol kinase OS=Drosophila melanogaster GN=rdgA PE=2 SV=2 PF00781//PF00609//PF00130//PF00628//PF13606//PF16866//PF00023 Diacylglycerol kinase catalytic domain//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//Ankyrin repeat//PHD-finger//Ankyrin repeat GO:0007205//GO:0009395//GO:0035556//GO:0046486 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//intracellular signal transduction//glycerolipid metabolic process GO:0004143//GO:0016301//GO:0005515 diacylglycerol kinase activity//kinase activity//protein binding -- -- KOG0782 Predicted diacylglycerol kinase Cluster-8309.22825 BF_2 80.47 0.45 7847 189234316 XP_972412.2 4154 0.0e+00 PREDICTED: eye-specific diacylglycerol kinase isoform X1 [Tribolium castaneum] 808145633 XM_012318648.1 294 1.31792e-149 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q13574 1713 4.9e-189 Diacylglycerol kinase zeta OS=Homo sapiens GN=DGKZ PE=1 SV=3 PF00609//PF00130//PF00781//PF03985//PF16866//PF01757//PF00628 Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase catalytic domain//Paf1//PHD-finger//Acyltransferase family//PHD-finger GO:0046486//GO:0035556//GO:0016570//GO:0006368//GO:0007205//GO:0009395 glycerolipid metabolic process//intracellular signal transduction//histone modification//transcription elongation from RNA polymerase II promoter//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process GO:0016747//GO:0016301//GO:0005515//GO:0004143 transferase activity, transferring acyl groups other than amino-acyl groups//kinase activity//protein binding//diacylglycerol kinase activity GO:0016593 Cdc73/Paf1 complex KOG0782 Predicted diacylglycerol kinase Cluster-8309.22828 BF_2 180.52 6.52 1445 91093365 XP_969666.1 1939 1.4e-214 PREDICTED: nedd8-activating enzyme E1 catalytic subunit [Tribolium castaneum]>gi|270015296|gb|EFA11744.1| hypothetical protein TcasGA2_TC004234 [Tribolium castaneum] -- -- -- -- -- K10686 UBE1C, UBA3 ubiquitin-activating enzyme E1 C http://www.genome.jp/dbget-bin/www_bget?ko:K10686 Q7ZVX6 1606 2.3e-177 NEDD8-activating enzyme E1 catalytic subunit OS=Danio rerio GN=uba3 PE=2 SV=1 PF08825//PF00070//PF00899 E2 binding domain//Pyridine nucleotide-disulphide oxidoreductase//ThiF family GO:0055114//GO:0045116 oxidation-reduction process//protein neddylation GO:0008641//GO:0016491//GO:0005524//GO:0016881 small protein activating enzyme activity//oxidoreductase activity//ATP binding//acid-amino acid ligase activity -- -- KOG2015 NEDD8-activating complex, catalytic component UBA3 Cluster-8309.22830 BF_2 258.05 2.45 4696 91086797 XP_973406.1 1419 8.8e-154 PREDICTED: CTD small phosphatase-like protein 2 [Tribolium castaneum]>gi|270009707|gb|EFA06155.1| hypothetical protein TcasGA2_TC009000 [Tribolium castaneum] 642929007 XM_008197430.1 42 9.58935e-10 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 8 (LOC662164), mRNA K17616 CTDSPL2 CTD small phosphatase-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17616 Q08BB5 687 2.7e-70 CTD small phosphatase-like protein 2-A OS=Danio rerio GN=ctdspl2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.22831 BF_2 125.24 0.80 6805 642915750 XP_008190789.1 4165 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.93718e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.8e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.22833 BF_2 50.92 0.38 5877 270015587 EFA12035.1 2530 1.6e-282 hypothetical protein TcasGA2_TC001452 [Tribolium castaneum] 642927958 XR_511541.1 53 9.22623e-16 PREDICTED: Tribolium castaneum transcriptional adapter 2B (LOC663682), transcript variant X2, misc_RNA K11673 ACTR8, ARP8, INO80N actin-related protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11673 Q0IEG8 1666 1.0e-183 Actin-related protein 8 OS=Aedes aegypti GN=Arp8 PE=3 SV=1 PF00569//PF06723//PF04433 Zinc finger, ZZ type//MreB/Mbl protein//SWIRM domain GO:0000902 cell morphogenesis GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0797 Actin-related protein Cluster-8309.22835 BF_2 26.72 0.92 1499 189235224 XP_967725.2 1833 2.8e-202 PREDICTED: coatomer subunit delta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 1294 3.6e-141 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.22839 BF_2 475.19 9.03 2489 91084135 XP_967479.1 1350 4.6e-146 PREDICTED: porphobilinogen deaminase [Tribolium castaneum]>gi|270006650|gb|EFA03098.1| hypothetical protein TcasGA2_TC013007 [Tribolium castaneum] -- -- -- -- -- K01749 hemC, HMBS hydroxymethylbilane synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01749 Q2KIN5 699 5.9e-72 Porphobilinogen deaminase OS=Bos taurus GN=HMBS PE=2 SV=1 PF01379//PF03900 Porphobilinogen deaminase, dipyromethane cofactor binding domain//Porphobilinogen deaminase, C-terminal domain GO:0044237//GO:0033014//GO:0015994//GO:0071704 cellular metabolic process//tetrapyrrole biosynthetic process//chlorophyll metabolic process//organic substance metabolic process GO:0004418 hydroxymethylbilane synthase activity -- -- KOG2892 Porphobilinogen deaminase Cluster-8309.22840 BF_2 431.81 7.94 2563 91084135 XP_967479.1 1187 3.8e-127 PREDICTED: porphobilinogen deaminase [Tribolium castaneum]>gi|270006650|gb|EFA03098.1| hypothetical protein TcasGA2_TC013007 [Tribolium castaneum] -- -- -- -- -- K01749 hemC, HMBS hydroxymethylbilane synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01749 P22907 797 2.6e-83 Porphobilinogen deaminase OS=Mus musculus GN=Hmbs PE=1 SV=2 PF03900//PF01379 Porphobilinogen deaminase, C-terminal domain//Porphobilinogen deaminase, dipyromethane cofactor binding domain GO:0018160//GO:0015994//GO:0033014 peptidyl-pyrromethane cofactor linkage//chlorophyll metabolic process//tetrapyrrole biosynthetic process GO:0004418 hydroxymethylbilane synthase activity -- -- KOG2892 Porphobilinogen deaminase Cluster-8309.22841 BF_2 6.40 0.47 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22845 BF_2 7.20 1.19 541 270006733 EFA03181.1 151 1.1e-07 hypothetical protein TcasGA2_TC013101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22851 BF_2 23.00 0.99 1256 852808191 XP_012892241.1 180 1.1e-10 PREDICTED: zinc finger protein 180-like [Dipodomys ordii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86UE3 168 1.1e-10 Zinc finger protein 546 OS=Homo sapiens GN=ZNF546 PE=2 SV=2 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.22854 BF_2 19.00 2.56 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22856 BF_2 48.00 0.96 2370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22859 BF_2 32.00 2.92 745 91082383 XP_968748.1 213 9.6e-15 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 160 5.6e-10 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.22860 BF_2 80.26 3.12 1365 751224154 XP_011165403.1 664 9.0e-67 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22861 BF_2 452.00 6.94 3010 642912013 XP_008199060.1 659 7.5e-66 PREDICTED: uncharacterized protein LOC103314519 [Tribolium castaneum]>gi|270015103|gb|EFA11551.1| branchless [Tribolium castaneum] -- -- -- -- -- K04358 FGF fibroblast growth factor http://www.genome.jp/dbget-bin/www_bget?ko:K04358 P41444 277 6.1e-23 Fibroblast growth factor homolog OS=Autographa californica nuclear polyhedrosis virus GN=FGF PE=3 SV=1 PF15234//PF00167 Linker for activation of T-cells//Fibroblast growth factor GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.22862 BF_2 7.41 0.47 949 642937533 XP_008199086.1 233 5.9e-17 PREDICTED: F-box only protein 9 [Tribolium castaneum] -- -- -- -- -- K10295 FBXO9 F-box protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10295 Q6P3K3 155 2.7e-09 F-box only protein 9 OS=Danio rerio GN=fbxo9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.22867 BF_2 833.05 9.68 3887 478256717 ENN76898.1 281 6.6e-22 hypothetical protein YQE_06546, partial [Dendroctonus ponderosae]>gi|478266402|gb|ENN82785.1| hypothetical protein YQE_00848, partial [Dendroctonus ponderosae]>gi|546681300|gb|ERL91414.1| hypothetical protein D910_08746 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22869 BF_2 1023.67 12.63 3678 478254444 ENN74696.1 1939 3.5e-214 hypothetical protein YQE_08813, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIL5 988 2.7e-105 Beta-galactosidase-1-like protein 3 OS=Rattus norvegicus GN=Glb1l3 PE=2 SV=1 PF13855//PF00150//PF00560//PF02449 Leucine rich repeat//Cellulase (glycosyl hydrolase family 5)//Leucine Rich Repeat//Beta-galactosidase GO:0006027//GO:0006012//GO:0006687//GO:0046486//GO:0005975 glycosaminoglycan catabolic process//galactose metabolic process//glycosphingolipid metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0005515//GO:0004553//GO:0004565 protein binding//hydrolase activity, hydrolyzing O-glycosyl compounds//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.22870 BF_2 180.60 3.50 2445 642939462 XP_008200412.1 1546 8.6e-169 PREDICTED: inhibitor of nuclear factor kappa-B kinase subunit beta-like isoform X1 [Tribolium castaneum]>gi|270016524|gb|EFA12970.1| immune response deficient 5 [Tribolium castaneum] -- -- -- -- -- K07209 IKBKB, IKKB inhibitor of nuclear factor kappa-B kinase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K07209 Q6GM53 666 3.9e-68 Inhibitor of nuclear factor kappa-B kinase subunit alpha OS=Xenopus laevis GN=chuk PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.22871 BF_2 432.87 3.44 5544 291463254 NP_001167546.1 3416 0.0e+00 receptor type guanylyl cyclase-like precursor [Tribolium castaneum]>gi|270014697|gb|EFA11145.1| hypothetical protein TcasGA2_TC004747 [Tribolium castaneum] 768406042 XM_011600843.1 174 4.74244e-83 PREDICTED: Aquila chrysaetos canadensis natriuretic peptide receptor 2 (NPR2), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P46197 1837 1.4e-203 Atrial natriuretic peptide receptor 2 OS=Bos taurus GN=NPR2 PE=2 SV=1 PF00211//PF06305//PF07714//PF00069//PF14867//PF07701 Adenylate and Guanylate cyclase catalytic domain//Protein of unknown function (DUF1049)//Protein tyrosine kinase//Protein kinase domain//Lantibiotic alpha//Heme NO binding associated GO:0009190//GO:0035556//GO:0050830//GO:0006144//GO:0006468//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//defense response to Gram-positive bacterium//purine nucleobase metabolic process//protein phosphorylation//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0004672//GO:0000166//GO:0016772//GO:0004383//GO:0005524 phosphorus-oxygen lyase activity//protein kinase activity//nucleotide binding//transferase activity, transferring phosphorus-containing groups//guanylate cyclase activity//ATP binding GO:0005887 integral component of plasma membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.22873 BF_2 100.92 2.37 2065 167234445 NP_001107837.1 1320 1.2e-142 hedgehog precursor [Tribolium castaneum] -- -- -- -- -- K11988 SHH sonic hedgehog http://www.genome.jp/dbget-bin/www_bget?ko:K11988 Q90419 922 6.8e-98 Tiggy-winkle hedgehog protein OS=Danio rerio GN=shhb PE=1 SV=1 PF01079//PF01085//PF05203 Hint module//Hedgehog amino-terminal signalling domain//Hom_end-associated Hint GO:0006508//GO:0030908//GO:0007267 proteolysis//protein splicing//cell-cell signaling GO:0008233 peptidase activity -- -- KOG3638 Sonic hedgehog and related proteins Cluster-8309.22876 BF_2 1056.42 12.48 3827 642927147 XP_008195157.1 3834 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 425 5.3e-40 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.22877 BF_2 31.96 0.36 3987 270014969 EFA11417.1 3464 0.0e+00 hypothetical protein TcasGA2_TC013593 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1321 7.1e-144 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF00103//PF08123//PF02390 Somatotropin hormone family//Histone methylation protein DOT1//Putative methyltransferase GO:0006554//GO:0008033//GO:0006400//GO:0009451//GO:0006479//GO:0007165 lysine catabolic process//tRNA processing//tRNA modification//RNA modification//protein methylation//signal transduction GO:0008176//GO:0005179//GO:0018024 tRNA (guanine-N7-)-methyltransferase activity//hormone activity//histone-lysine N-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.22880 BF_2 420.63 2.09 8700 478262858 ENN81340.1 3676 0.0e+00 hypothetical protein YQE_02251, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VFB7 1853 3.2e-205 Trafficking protein particle complex subunit 10 OS=Drosophila melanogaster GN=SIDL PE=1 SV=1 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG1931 Putative transmembrane protein Cluster-8309.22884 BF_2 17.33 0.81 1185 642935340 XP_968306.2 543 8.4e-53 PREDICTED: kelch domain-containing protein 10 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZB86 344 4.1e-31 Kelch domain-containing protein 10 homolog OS=Drosophila melanogaster GN=slim PE=1 SV=1 PF01344//PF09187//PF07646 Kelch motif//Domain of unknown function(DUF1950)//Kelch motif GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.22886 BF_2 34.82 0.81 2075 642912369 XP_008199613.1 374 5.8e-33 PREDICTED: diuretic hormone class 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLK4 172 6.3e-11 Diuretic hormone class 2 OS=Drosophila melanogaster GN=Dh31 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2289 BF_2 7.00 0.33 1178 307190333 EFN74406.1 720 2.5e-73 hypothetical protein EAG_08095, partial [Camponotus floridanus] 462334478 APGK01038567.1 51 2.33622e-15 Dendroctonus ponderosae Seq01038577, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF09360//PF00703 Iron-binding zinc finger CDGSH type//Glycosyl hydrolases family 2 GO:0005975 carbohydrate metabolic process GO:0051537//GO:0004553 2 iron, 2 sulfur cluster binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.22892 BF_2 68.00 3.06 1216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.22893 BF_2 77.00 1.36 2659 478255299 ENN75525.1 179 3.0e-10 hypothetical protein YQE_07868, partial [Dendroctonus ponderosae]>gi|546683147|gb|ERL92998.1| hypothetical protein D910_10301 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22894 BF_2 69.13 0.55 5524 270016478 EFA12924.1 1944 1.4e-214 hypothetical protein TcasGA2_TC006994 [Tribolium castaneum] 827555134 XM_012693612.1 128 1.76068e-57 PREDICTED: Bombyx mori USP6 N-terminal-like protein (LOC101746723), mRNA -- -- -- -- Q80XC3 1096 1.2e-117 USP6 N-terminal-like protein OS=Mus musculus GN=Usp6nl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.22897 BF_2 356.13 10.43 1715 91087901 XP_970608.1 1202 4.6e-129 PREDICTED: protein cereblon [Tribolium castaneum]>gi|270012017|gb|EFA08465.1| hypothetical protein TcasGA2_TC006114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CF65 547 1.7e-54 Protein cereblon OS=Gallus gallus GN=CRBN PE=1 SV=1 PF02190 ATP-dependent protease La (LON) substrate-binding domain GO:0006508//GO:0006510 proteolysis//obsolete ATP-dependent proteolysis GO:0004176 ATP-dependent peptidase activity -- -- KOG1400 Predicted ATP-dependent protease PIL, contains LON domain Cluster-8309.22905 BF_2 8.00 1.81 472 641647755 XP_008179502.1 146 3.6e-07 PREDICTED: uncharacterized protein LOC103308224 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22907 BF_2 419.88 5.87 3280 642912029 XP_008199066.1 1820 1.9e-200 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 375 2.9e-34 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF02460//PF00873 Patched family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.22909 BF_2 86.95 0.64 5997 91088115 XP_969791.1 1930 6.2e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.9e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF04851//PF01105 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//emp24/gp25L/p24 family/GOLD GO:0006810 transport GO:0008026//GO:0003676//GO:0016787//GO:0003677//GO:0005524 ATP-dependent helicase activity//nucleic acid binding//hydrolase activity//DNA binding//ATP binding GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.22911 BF_2 188.24 5.29 1775 91087821 XP_966824.1 1091 3.6e-116 PREDICTED: two pore potassium channel protein sup-9 [Tribolium castaneum]>gi|270011967|gb|EFA08415.1| hypothetical protein TcasGA2_TC006062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 210 2.1e-15 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF00520//PF08586//PF01007 Ion transport protein//RSC complex, Rsc14/Ldb7 subunit//Inward rectifier potassium channel GO:0006811//GO:0043044//GO:0006813//GO:0006810//GO:0055085 ion transport//ATP-dependent chromatin remodeling//potassium ion transport//transport//transmembrane transport GO:0005216//GO:0005242 ion channel activity//inward rectifier potassium channel activity GO:0008076//GO:0016020//GO:0016021//GO:0016586 voltage-gated potassium channel complex//membrane//integral component of membrane//RSC complex -- -- Cluster-8309.22915 BF_2 68.00 3.92 1012 642929480 XP_008195856.1 759 6.4e-78 PREDICTED: HD domain-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642929482|ref|XP_008195857.1| PREDICTED: HD domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07023 K07023 putative hydrolases of HD superfamily http://www.genome.jp/dbget-bin/www_bget?ko:K07023 Q7Z4H3 423 2.4e-40 HD domain-containing protein 2 OS=Homo sapiens GN=HDDC2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3197 Predicted hydrolases of HD superfamily Cluster-8309.22919 BF_2 103.42 1.52 3128 642915391 XP_008190597.1 403 3.8e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 2.8574e-33 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 2.0e-21 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF02297//PF07393 Cytochrome oxidase c subunit VIb//Exocyst complex component Sec10 GO:0006123//GO:0048278//GO:0006887//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//vesicle docking//exocytosis//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005739//GO:0005737 respiratory chain complex IV//mitochondrion//cytoplasm KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.22920 BF_2 344.00 131.73 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF00537//PF10280 Arthropod defensin//Scorpion toxin-like domain//Mediator complex protein GO:0006357//GO:0006810//GO:0006952 regulation of transcription from RNA polymerase II promoter//transport//defense response GO:0001104//GO:0008200 RNA polymerase II transcription cofactor activity//ion channel inhibitor activity GO:0005576//GO:0016592 extracellular region//mediator complex -- -- Cluster-8309.22921 BF_2 22.00 2.52 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22923 BF_2 15.00 0.35 2064 189235084 XP_967723.2 968 7.6e-102 PREDICTED: frequenin-1 [Tribolium castaneum]>gi|270003861|gb|EFA00309.1| hypothetical protein TcasGA2_TC003144 [Tribolium castaneum] 768415624 XM_011550068.1 225 7.7926e-112 PREDICTED: Plutella xylostella frequenin-1 (LOC105380494), transcript variant X2, mRNA -- -- -- -- P37236 909 2.2e-96 Frequenin-1 OS=Drosophila melanogaster GN=Frq1 PE=2 SV=2 PF08117//PF13202//PF00036//PF12763//PF13833//PF10591//PF13405//PF13499 Ptu family//EF hand//EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair GO:0007165//GO:0009405//GO:0006810 signal transduction//pathogenesis//transport GO:0005509//GO:0019855//GO:0005515 calcium ion binding//calcium channel inhibitor activity//protein binding GO:0005578//GO:0005576 proteinaceous extracellular matrix//extracellular region KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.22925 BF_2 155.07 1.94 3631 642933999 XP_008197598.1 837 2.1e-86 PREDICTED: biorientation of chromosomes in cell division protein 1-like 1 [Tribolium castaneum]>gi|270013676|gb|EFA10124.1| hypothetical protein TcasGA2_TC012304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96IK1 368 2.1e-33 Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens GN=BOD1 PE=1 SV=2 PF08287 Spc19 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0005876//GO:0042729 spindle microtubule//DASH complex -- -- Cluster-8309.22928 BF_2 178.80 2.25 3613 642933999 XP_008197598.1 837 2.1e-86 PREDICTED: biorientation of chromosomes in cell division protein 1-like 1 [Tribolium castaneum]>gi|270013676|gb|EFA10124.1| hypothetical protein TcasGA2_TC012304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96IK1 368 2.1e-33 Biorientation of chromosomes in cell division protein 1 OS=Homo sapiens GN=BOD1 PE=1 SV=2 PF08287 Spc19 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0005876//GO:0042729 spindle microtubule//DASH complex -- -- Cluster-8309.22930 BF_2 57.66 0.61 4247 91089441 XP_967682.1 2588 2.2e-289 PREDICTED: calpain-7 [Tribolium castaneum]>gi|642933281|ref|XP_008197356.1| PREDICTED: calpain-7 [Tribolium castaneum]>gi|270012563|gb|EFA09011.1| hypothetical protein TcasGA2_TC006719 [Tribolium castaneum] -- -- -- -- -- K08576 CAPN7 calpain-7 http://www.genome.jp/dbget-bin/www_bget?ko:K08576 Q9R1S8 1801 1.6e-199 Calpain-7 OS=Mus musculus GN=Capn7 PE=2 SV=1 PF00515//PF13414//PF00648//PF13176//PF16785 Tetratricopeptide repeat//TPR repeat//Calpain family cysteine protease//Tetratricopeptide repeat//Small metal-binding protein GO:0006508 proteolysis GO:0004198//GO:0005515//GO:0046872 calcium-dependent cysteine-type endopeptidase activity//protein binding//metal ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.22931 BF_2 646.34 6.97 4164 478256753 ENN76934.1 2980 0.0e+00 hypothetical protein YQE_06581, partial [Dendroctonus ponderosae]>gi|546679210|gb|ERL89704.1| hypothetical protein D910_07067 [Dendroctonus ponderosae] -- -- -- -- -- K08576 CAPN7 calpain-7 http://www.genome.jp/dbget-bin/www_bget?ko:K08576 Q9R1S8 2025 1.7e-225 Calpain-7 OS=Mus musculus GN=Capn7 PE=2 SV=1 PF00515//PF13414//PF00648//PF13176//PF16785 Tetratricopeptide repeat//TPR repeat//Calpain family cysteine protease//Tetratricopeptide repeat//Small metal-binding protein GO:0006508 proteolysis GO:0004198//GO:0005515//GO:0046872 calcium-dependent cysteine-type endopeptidase activity//protein binding//metal ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.22933 BF_2 9.00 0.43 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22936 BF_2 4.64 0.31 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22937 BF_2 14.94 0.33 2202 642912489 XP_008200886.1 1238 4.0e-133 PREDICTED: Fanconi anemia group I protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVI1 283 9.0e-24 Fanconi anemia group I protein OS=Homo sapiens GN=FANCI PE=1 SV=4 PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- KOG4553 Uncharacterized conserved protein Cluster-8309.22938 BF_2 536.11 5.43 4415 478251697 ENN72151.1 1254 1.1e-134 hypothetical protein YQE_11208, partial [Dendroctonus ponderosae]>gi|546680949|gb|ERL91123.1| hypothetical protein D910_08464 [Dendroctonus ponderosae] 817214294 XM_012427986.1 53 6.91691e-16 PREDICTED: Orussus abietinus F-box only protein 28 (LOC105701325), transcript variant X4, mRNA K10306 FBXO28 F-box protein 28 http://www.genome.jp/dbget-bin/www_bget?ko:K10306 Q2NL16 367 3.3e-33 F-box only protein 28 OS=Bos taurus GN=FBXO28 PE=2 SV=1 PF00646//PF15966//PF02601//PF13013//PF12937//PF01702 F-box domain//F-box//Exonuclease VII, large subunit//F-box-like domain//F-box-like//Queuine tRNA-ribosyltransferase GO:0008616//GO:0006308//GO:0006400 queuosine biosynthetic process//DNA catabolic process//tRNA modification GO:0008479//GO:0008855//GO:0005515 queuine tRNA-ribosyltransferase activity//exodeoxyribonuclease VII activity//protein binding GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.22941 BF_2 205.76 1.17 7674 91091886 XP_970165.1 4070 0.0e+00 PREDICTED: protein Daple [Tribolium castaneum]>gi|270001124|gb|EEZ97571.1| hypothetical protein TcasGA2_TC011433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P219 787 1.1e-81 Protein Daple OS=Homo sapiens GN=CCDC88C PE=1 SV=3 PF01112//PF13851//PF00170 Asparaginase//Growth-arrest specific micro-tubule binding//bZIP transcription factor GO:0006355//GO:0048870 regulation of transcription, DNA-templated//cell motility GO:0043565//GO:0016787//GO:0003700 sequence-specific DNA binding//hydrolase activity//transcription factor activity, sequence-specific DNA binding GO:0031514//GO:0005667 motile cilium//transcription factor complex KOG1592 Asparaginase Cluster-8309.22943 BF_2 107.67 0.61 7621 91091886 XP_970165.1 3210 0.0e+00 PREDICTED: protein Daple [Tribolium castaneum]>gi|270001124|gb|EEZ97571.1| hypothetical protein TcasGA2_TC011433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1G1 633 8.1e-64 Threonine aspartase 1 OS=Mus musculus GN=Tasp1 PE=2 SV=1 PF01112//PF13851//PF06005//PF01075//PF00170 Asparaginase//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//Glycosyltransferase family 9 (heptosyltransferase)//bZIP transcription factor GO:0008152//GO:0048870//GO:0006355//GO:0043093//GO:0000917 metabolic process//cell motility//regulation of transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly GO:0016757//GO:0016787//GO:0043565//GO:0003700 transferase activity, transferring glycosyl groups//hydrolase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0031514//GO:0005667//GO:0005737 motile cilium//transcription factor complex//cytoplasm KOG1592 Asparaginase Cluster-8309.22949 BF_2 19.00 4.93 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22953 BF_2 562.00 10.76 2472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22956 BF_2 139.19 1.60 3918 642911078 XP_008200566.1 2414 3.1e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 3.5e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF07808//PF01585//PF00641//PF13442//PF11648 RED-like protein N-terminal region//G-patch domain//Zn-finger in Ran binding protein and others//Cytochrome C oxidase, cbb3-type, subunit III//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0003676//GO:0009055//GO:0008270//GO:0000166//GO:0016817//GO:0020037 nucleic acid binding//electron carrier activity//zinc ion binding//nucleotide binding//hydrolase activity, acting on acid anhydrides//heme binding GO:0005622//GO:0005634 intracellular//nucleus KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.22958 BF_2 190.00 5.91 1632 332376645 AEE63462.1 1875 4.0e-207 unknown [Dendroctonus ponderosae]>gi|478255231|gb|ENN75460.1| hypothetical protein YQE_08010, partial [Dendroctonus ponderosae]>gi|546679675|gb|ERL90102.1| hypothetical protein D910_07456 [Dendroctonus ponderosae] -- -- -- -- -- K12844 PRPF31 U4/U6 small nuclear ribonucleoprotein PRP31 http://www.genome.jp/dbget-bin/www_bget?ko:K12844 Q8WWY3 1418 1.6e-155 U4/U6 small nuclear ribonucleoprotein Prp31 OS=Homo sapiens GN=PRPF31 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2574 mRNA splicing factor PRP31 Cluster-8309.22959 BF_2 33.42 0.42 3612 332374492 AEE62387.1 263 7.5e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P81656 146 1.1e-07 Venom allergen 5 OS=Polistes dominula PE=1 SV=2 PF07782 DC-STAMP-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.22963 BF_2 29.41 0.48 2838 751225380 XP_011166071.1 214 2.8e-14 PREDICTED: uncharacterized protein LOC105200296 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.22965 BF_2 77.05 0.54 6217 91091178 XP_971714.1 1911 1.0e-210 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] 564254995 XM_006266415.1 37 7.65503e-07 PREDICTED: Alligator mississippiensis F-box protein 21 (FBXO21), mRNA K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 1219 7.4e-132 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF02770//PF00441//PF12937//PF00646//PF01756//PF08755 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//F-box-like//F-box domain//Acyl-CoA oxidase//Hemimethylated DNA-binding protein YccV like GO:0006635//GO:0006637//GO:0055114//GO:0006631//GO:0006118 fatty acid beta-oxidation//acyl-CoA metabolic process//oxidation-reduction process//fatty acid metabolic process//obsolete electron transport GO:0005515//GO:0003677//GO:0003995//GO:0016627//GO:0003997 protein binding//DNA binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.22967 BF_2 2.84 2.14 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22968 BF_2 1.29 0.38 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22969 BF_2 18.70 0.96 1098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22970 BF_2 7.00 2.73 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03334 Na+/H+ antiporter subunit GO:0015672//GO:0015992 monovalent inorganic cation transport//proton transport GO:0005451 monovalent cation:proton antiporter activity -- -- -- -- Cluster-8309.22975 BF_2 9.00 0.35 1364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22980 BF_2 35.25 0.70 2408 270005418 EFA01866.1 1232 2.2e-132 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] -- -- -- -- -- K11405 HDAC8 histone deacetylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11405 Q8VH37 824 1.8e-86 Histone deacetylase 8 OS=Mus musculus GN=Hdac8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.22981 BF_2 109.08 1.68 3006 546683595 ERL93390.1 1233 2.1e-132 hypothetical protein D910_10682 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22983 BF_2 7.25 0.36 1138 762146544 XP_011456572.1 224 7.8e-16 PREDICTED: uncharacterized protein LOC105348724 [Crassostrea gigas]>gi|405962723|gb|EKC28372.1| hypothetical protein CGI_10023755 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22986 BF_2 429.18 4.52 4258 91084345 XP_972963.1 1762 1.3e-193 PREDICTED: SH2B adapter protein 2 isoform X1 [Tribolium castaneum]>gi|270008825|gb|EFA05273.1| hypothetical protein TcasGA2_TC015430 [Tribolium castaneum] -- -- -- -- -- K12459 SH2B1_3 SH2B adaptor protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12459 Q9UQQ2 476 7.3e-46 SH2B adapter protein 3 OS=Homo sapiens GN=SH2B3 PE=1 SV=2 PF01395//PF08916//PF00583//PF13508 PBP/GOBP family//Phenylalanine zipper//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967//GO:0007165//GO:0035556 acyl-carrier-protein biosynthetic process//signal transduction//intracellular signal transduction GO:0005543//GO:0008080//GO:0005549//GO:0004871 phospholipid binding//N-acetyltransferase activity//odorant binding//signal transducer activity GO:0005622 intracellular -- -- Cluster-8309.22990 BF_2 644.70 24.21 1401 91089019 XP_968547.1 309 1.3e-25 PREDICTED: mitogen-activated protein kinase kinase kinase 7 [Tribolium castaneum]>gi|270012716|gb|EFA09164.1| TGF-beta activated kinase 1 [Tribolium castaneum] -- -- -- -- -- K04427 MAP3K7, TAK1 mitogen-activated protein kinase kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04427 Q5RFL3 139 2.8e-07 Mitogen-activated protein kinase kinase kinase 7 OS=Pongo abelii GN=MAP3K7 PE=2 SV=1 PF13931 Kinesin-associated microtubule-binding GO:0016310 phosphorylation GO:0008017//GO:0004672 microtubule binding//protein kinase activity GO:0045298 tubulin complex -- -- Cluster-8309.22991 BF_2 125.29 6.20 1133 91089011 XP_968226.1 1028 4.6e-109 PREDICTED: nuclear RNA export factor 1 [Tribolium castaneum]>gi|270011540|gb|EFA07988.1| hypothetical protein TcasGA2_TC005575 [Tribolium castaneum] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q9U1H9 574 8.3e-58 Nuclear RNA export factor 1 OS=Drosophila melanogaster GN=sbr PE=1 SV=2 PF13855//PF09162 Leucine rich repeat//Tap, RNA-binding GO:0051028//GO:0006406 mRNA transport//mRNA export from nucleus GO:0005515//GO:0003723//GO:0097159//GO:1901363 protein binding//RNA binding//organic cyclic compound binding//heterocyclic compound binding GO:0005634//GO:0005737//GO:0044424 nucleus//cytoplasm//intracellular part KOG3763 mRNA export factor TAP/MEX67 Cluster-8309.22995 BF_2 46.00 3.33 865 332372907 AEE61595.1 376 1.4e-33 unknown [Dendroctonus ponderosae]>gi|478261028|gb|ENN80606.1| hypothetical protein YQE_02971, partial [Dendroctonus ponderosae] -- -- -- -- -- K02219 CKS1 cyclin-dependent kinase regulatory subunit CKS1 http://www.genome.jp/dbget-bin/www_bget?ko:K02219 Q0P5A5 303 1.7e-26 Cyclin-dependent kinases regulatory subunit 1 OS=Bos taurus GN=CKS1B PE=3 SV=1 PF01111 Cyclin-dependent kinase regulatory subunit GO:0007049//GO:0045859 cell cycle//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG3484 Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins Cluster-8309.22998 BF_2 11.00 0.32 1711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.22999 BF_2 7.00 0.82 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23 BF_2 2.00 0.90 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23001 BF_2 2.00 0.57 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23006 BF_2 41.13 0.83 2365 642914217 XP_008201594.1 1237 5.6e-133 PREDICTED: abl interactor 2-like [Tribolium castaneum]>gi|270001565|gb|EEZ98012.1| hypothetical protein TcasGA2_TC000412 [Tribolium castaneum] -- -- -- -- -- K05751 ABI2 abl interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05751 Q9NYB9 522 1.9e-51 Abl interactor 2 OS=Homo sapiens GN=ABI2 PE=1 SV=1 PF01110//PF14604//PF00018//PF01213//PF07815//PF00031 Ciliary neurotrophic factor//Variant SH3 domain//SH3 domain//Adenylate cyclase associated (CAP) N terminal//Abl-interactor HHR//Cystatin domain GO:0040007//GO:0007010 growth//cytoskeleton organization GO:0003779//GO:0004869//GO:0005515 actin binding//cysteine-type endopeptidase inhibitor activity//protein binding GO:0005737 cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.23007 BF_2 2.18 0.63 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23010 BF_2 289.09 4.08 3250 642937140 XP_008198709.1 1559 3.5e-170 PREDICTED: MMS19 nucleotide excision repair protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BP36 629 1.0e-63 MMS19 nucleotide excision repair protein homolog OS=Bos taurus GN=MMS19 PE=2 SV=3 PF02985//PF17082//PF03274 HEAT repeat//Spindle Pole Component 29//Foamy virus BEL 1/2 protein GO:0045893//GO:0016032//GO:0030474 positive regulation of transcription, DNA-templated//viral process//spindle pole body duplication GO:0005200//GO:0005515 structural constituent of cytoskeleton//protein binding GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG1967 DNA repair/transcription protein Mms19 Cluster-8309.23012 BF_2 31.98 0.44 3336 642937140 XP_008198709.1 1534 2.9e-167 PREDICTED: MMS19 nucleotide excision repair protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BP36 627 1.8e-63 MMS19 nucleotide excision repair protein homolog OS=Bos taurus GN=MMS19 PE=2 SV=3 PF17082//PF03274//PF02985 Spindle Pole Component 29//Foamy virus BEL 1/2 protein//HEAT repeat GO:0030474//GO:0045893//GO:0016032 spindle pole body duplication//positive regulation of transcription, DNA-templated//viral process GO:0005515//GO:0005200 protein binding//structural constituent of cytoskeleton GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG1967 DNA repair/transcription protein Mms19 Cluster-8309.23017 BF_2 333.03 1.42 10106 91076250 XP_966964.1 1806 2.5e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 2.01356e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 4.6e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF00050//PF00036//PF07648//PF08527//PF16554//PF15009//PF13833//PF10591 Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain//Protein-arginine deiminase (PAD) middle domain//Dimerisation domain of d-ornithine 4,5-aminomutase//Transmembrane protein 173//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region GO:0032481//GO:0006807//GO:0002218//GO:0018101//GO:0007165 positive regulation of type I interferon production//nitrogen compound metabolic process//activation of innate immune response//protein citrullination//signal transduction GO:0004668//GO:0005509//GO:0005515//GO:0046983 protein-arginine deiminase activity//calcium ion binding//protein binding//protein dimerization activity GO:0005737//GO:0005578 cytoplasm//proteinaceous extracellular matrix KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.23020 BF_2 20.02 0.76 1385 478257766 ENN77909.1 526 9.1e-51 hypothetical protein YQE_05586, partial [Dendroctonus ponderosae] -- -- -- -- -- K19030 PFKFB4 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K19030 Q91348 319 3.8e-28 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Gallus gallus PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.23022 BF_2 22.45 1.15 1105 642937495 XP_008198863.1 197 1.0e-12 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23024 BF_2 59.13 0.86 3166 -- -- -- -- -- 301173032 NR_036303.1 37 3.87643e-07 Tribolium castaneum microRNA mir-277 (Mir277), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23026 BF_2 97.05 1.26 3497 642922142 XP_970966.2 1222 4.5e-131 PREDICTED: uncharacterized protein LOC659581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05817 Oligosaccharyltransferase subunit Ribophorin II GO:0006487 protein N-linked glycosylation -- -- GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex -- -- Cluster-8309.23027 BF_2 49.00 0.50 4356 270002498 EEZ98945.1 226 1.8e-15 hypothetical protein TcasGA2_TC004569 [Tribolium castaneum] 642912108 XM_008202587.1 94 1.10216e-38 PREDICTED: Tribolium castaneum V-type proton ATPase 116 kDa subunit a isoform 1 (LOC655096), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23028 BF_2 321.61 11.82 1425 546672777 ERL84533.1 903 1.8e-94 hypothetical protein D910_01963 [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q06AU5 721 9.4e-75 Ras-related protein Rab-32 OS=Sus scrofa GN=RAB32 PE=2 SV=1 PF08477//PF01926//PF00025//PF02367//PF00503//PF04670//PF00071//PF10662 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation GO:0007264//GO:0007186//GO:0002949//GO:0007165//GO:0006576 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification//signal transduction//cellular biogenic amine metabolic process GO:0005525//GO:0019001//GO:0004871//GO:0003924//GO:0005524//GO:0031683 GTP binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding -- -- -- -- Cluster-8309.23030 BF_2 194.97 2.63 3387 817061123 XP_012252151.1 255 5.9e-19 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23034 BF_2 8.37 0.37 1227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23036 BF_2 94.50 1.36 3199 642912647 XP_008200948.1 296 9.9e-24 PREDICTED: CREB/ATF bZIP transcription factor-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01253//PF05791//PF01166//PF00170//PF07716 Translation initiation factor SUI1//Bacillus haemolytic enterotoxin (HBL)//TSC-22/dip/bun family//bZIP transcription factor//Basic region leucine zipper GO:0006355//GO:0006413//GO:0006446//GO:0009405 regulation of transcription, DNA-templated//translational initiation//regulation of translational initiation//pathogenesis GO:0003700//GO:0043565//GO:0003743 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//translation initiation factor activity GO:0005840//GO:0016020//GO:0005667 ribosome//membrane//transcription factor complex -- -- Cluster-8309.23037 BF_2 6.00 0.97 546 478252250 ENN72678.1 171 5.2e-10 hypothetical protein YQE_10776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23038 BF_2 3.00 1.77 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23042 BF_2 97.37 1.52 2969 478250852 ENN71341.1 1034 2.4e-109 hypothetical protein YQE_11956, partial [Dendroctonus ponderosae]>gi|546678340|gb|ERL88982.1| hypothetical protein D910_06360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VPK7 587 6.8e-59 Putative tRNA pseudouridine synthase Pus10 OS=Drosophila melanogaster GN=Pus10 PE=2 SV=2 PF02058//PF01416 Guanylin precursor//tRNA pseudouridine synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0030250//GO:0009982//GO:0003723 guanylate cyclase activator activity//pseudouridine synthase activity//RNA binding GO:0005576 extracellular region KOG2364 Predicted pseudouridylate synthase Cluster-8309.23044 BF_2 22.54 0.40 2638 91085293 XP_968143.1 1111 2.5e-118 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 Q3SZA5 642 2.5e-65 Spermine synthase OS=Bos taurus GN=SMS PE=2 SV=1 PF00891//PF03602//PF05175//PF01728//PF08241//PF02390 O-methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain//FtsJ-like methyltransferase//Methyltransferase domain//Putative methyltransferase GO:0009451//GO:0008033//GO:0006597//GO:0019482//GO:0032259//GO:0006400//GO:0008152//GO:0006525//GO:0031167//GO:0006560 RNA modification//tRNA processing//spermine biosynthetic process//beta-alanine metabolic process//methylation//tRNA modification//metabolic process//arginine metabolic process//rRNA methylation//proline metabolic process GO:0016768//GO:0008176//GO:0008168//GO:0008171 spermine synthase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity//O-methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.23045 BF_2 513.57 11.29 2190 642914217 XP_008201594.1 1784 1.9e-196 PREDICTED: abl interactor 2-like [Tribolium castaneum]>gi|270001565|gb|EEZ98012.1| hypothetical protein TcasGA2_TC000412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NYB9 522 1.7e-51 Abl interactor 2 OS=Homo sapiens GN=ABI2 PE=1 SV=1 PF00031//PF07815//PF01110//PF14604//PF00018 Cystatin domain//Abl-interactor HHR//Ciliary neurotrophic factor//Variant SH3 domain//SH3 domain GO:0040007 growth GO:0004869//GO:0005515 cysteine-type endopeptidase inhibitor activity//protein binding GO:0005737 cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.23053 BF_2 255.73 3.03 3822 602166190 AHN85842.1 1751 2.3e-192 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1334 2.1e-145 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF01769//PF00001 Divalent cation transporter//7 transmembrane receptor (rhodopsin family) GO:0006812//GO:0007186 cation transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0008324 G-protein coupled receptor activity//cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.23054 BF_2 162.94 1.92 3829 602166190 AHN85842.1 1751 2.3e-192 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1334 2.1e-145 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF01769//PF00001 Divalent cation transporter//7 transmembrane receptor (rhodopsin family) GO:0006812//GO:0007186 cation transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0008324 G-protein coupled receptor activity//cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.23055 BF_2 304.00 6.15 2356 755944119 XP_011299351.1 1303 1.2e-140 PREDICTED: NADPH:adrenodoxin oxidoreductase, mitochondrial [Fopius arisanus]>gi|755944122|ref|XP_011299352.1| PREDICTED: NADPH:adrenodoxin oxidoreductase, mitochondrial [Fopius arisanus]>gi|755944125|ref|XP_011299353.1| PREDICTED: NADPH:adrenodoxin oxidoreductase, mitochondrial [Fopius arisanus] -- -- -- -- -- K18914 FDXR adrenodoxin-NADP+ reductase http://www.genome.jp/dbget-bin/www_bget?ko:K18914 Q9V3T9 1139 5.3e-123 NADPH:adrenodoxin oxidoreductase, mitochondrial OS=Drosophila melanogaster GN=dare PE=2 SV=1 PF00163//PF07992//PF06156//PF01494//PF01479 Ribosomal protein S4/S9 N-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//Protein of unknown function (DUF972)//FAD binding domain//S4 domain GO:0006260//GO:0055114 DNA replication//oxidation-reduction process GO:0019843//GO:0003723//GO:0071949//GO:0016491 rRNA binding//RNA binding//FAD binding//oxidoreductase activity GO:0005622 intracellular KOG1800 Ferredoxin/adrenodoxin reductase Cluster-8309.23057 BF_2 19.05 1.31 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23058 BF_2 93.44 1.09 3882 546682322 ERL92270.1 2218 1.6e-246 hypothetical protein D910_09587 [Dendroctonus ponderosae] 828212418 XM_004208898.2 42 7.9143e-10 PREDICTED: Hydra vulgaris protein VAC14 homolog (LOC100212842), mRNA K15305 VAC14, TAX1BP2 vacuole morphology and inheritance protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15305 Q5ZIW5 1562 7.8e-172 Protein VAC14 homolog OS=Gallus gallus GN=VAC14 PE=2 SV=1 PF02985//PF03719 HEAT repeat//Ribosomal protein S5, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0212 Uncharacterized conserved protein Cluster-8309.23059 BF_2 365.49 5.36 3138 642928829 XP_008195578.1 1400 9.3e-152 PREDICTED: protein VAC14 homolog [Tribolium castaneum] 828212418 XM_004208898.2 42 6.3833e-10 PREDICTED: Hydra vulgaris protein VAC14 homolog (LOC100212842), mRNA K15305 VAC14, TAX1BP2 vacuole morphology and inheritance protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15305 A2VE70 999 1.2e-106 Protein VAC14 homolog OS=Bos taurus GN=VAC14 PE=2 SV=1 PF07571//PF02985//PF03719 TAF6 C-terminal HEAT repeat domain//HEAT repeat//Ribosomal protein S5, C-terminal domain GO:0051090//GO:0006412//GO:0042254 regulation of sequence-specific DNA binding transcription factor activity//translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005634//GO:0005840 nucleus//ribosome KOG0212 Uncharacterized conserved protein Cluster-8309.23060 BF_2 19.28 0.35 2605 478253101 ENN73474.1 178 3.9e-10 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04508 Viral A-type inclusion protein repeat GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.23062 BF_2 431.77 22.96 1074 91079574 XP_966886.1 962 2.0e-101 PREDICTED: ubiquitin carboxyl-terminal hydrolase [Tribolium castaneum]>gi|270004456|gb|EFA00904.1| hypothetical protein TcasGA2_TC003809 [Tribolium castaneum] -- -- -- -- -- K05609 UCHL3, YUH1 ubiquitin carboxyl-terminal hydrolase L3 http://www.genome.jp/dbget-bin/www_bget?ko:K05609 P35122 640 1.8e-65 Ubiquitin carboxyl-terminal hydrolase OS=Drosophila melanogaster GN=Uch PE=2 SV=2 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006508//GO:0006511//GO:0016579 proteolysis//ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0004843//GO:0004221 ubiquitin-specific protease activity//obsolete ubiquitin thiolesterase activity GO:0005622 intracellular KOG1415 Ubiquitin C-terminal hydrolase UCHL1 Cluster-8309.23065 BF_2 15.05 0.74 1139 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23066 BF_2 20.80 0.46 2165 478261315 ENN80731.1 1229 4.3e-132 hypothetical protein YQE_02839, partial [Dendroctonus ponderosae] 391330831 XM_003739808.1 45 9.42385e-12 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 461 2.0e-44 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF01844 HNH endonuclease -- -- GO:0004519//GO:0003676 endonuclease activity//nucleic acid binding -- -- -- -- Cluster-8309.23069 BF_2 68.67 1.40 2333 642932427 XP_008197107.1 1468 9.0e-160 PREDICTED: uncharacterized protein KIAA0195 isoform X2 [Tribolium castaneum]>gi|270012352|gb|EFA08800.1| hypothetical protein TcasGA2_TC006494 [Tribolium castaneum] 391330831 XM_003739808.1 45 1.01671e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 570 5.0e-57 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF03533//PF01844//PF02313 SPO11 homologue//HNH endonuclease//Fumarate reductase subunit D GO:0006106//GO:0007131 fumarate metabolic process//reciprocal meiotic recombination GO:0003676//GO:0003677//GO:0004519 nucleic acid binding//DNA binding//endonuclease activity GO:0016020 membrane -- -- Cluster-8309.2307 BF_2 1.86 0.75 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23070 BF_2 73.87 0.77 4306 642932427 XP_008197107.1 3906 0.0e+00 PREDICTED: uncharacterized protein KIAA0195 isoform X2 [Tribolium castaneum]>gi|270012352|gb|EFA08800.1| hypothetical protein TcasGA2_TC006494 [Tribolium castaneum] 391330831 XM_003739808.1 45 1.8886e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 1284 1.5e-139 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF01567//PF01844 Hantavirus glycoprotein G1//HNH endonuclease GO:0030683 evasion or tolerance by virus of host immune response GO:0003676//GO:0004519 nucleic acid binding//endonuclease activity GO:0019012 virion KOG4383 Uncharacterized conserved protein Cluster-8309.23072 BF_2 140.21 3.03 2225 642915956 XP_008190826.1 2982 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 642915955 XM_008192604.1 551 0 PREDICTED: Tribolium castaneum protein kinase C, brain isozyme-like (LOC656250), mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 2495 2.9e-280 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF07714//PF00168//PF00628//PF07649//PF00069//PF09472//PF00130 Protein tyrosine kinase//C2 domain//PHD-finger//C1-like domain//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0055114//GO:0035556//GO:0015948//GO:0006468//GO:0046656 oxidation-reduction process//intracellular signal transduction//methanogenesis//protein phosphorylation//folic acid biosynthetic process GO:0004672//GO:0047134//GO:0005524//GO:0030269//GO:0005515 protein kinase activity//protein-disulfide reductase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity//protein binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.23076 BF_2 46.00 0.96 2293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15497//PF14620 snRNA-activating protein complex subunit 19, SNAPc subunit 19//YpeB sporulation GO:0009847//GO:0006366//GO:0006384 spore germination//transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase III promoter GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.23079 BF_2 44.00 0.71 2897 646695057 KDR08231.1 880 1.7e-91 hypothetical protein L798_01949 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9D9H8 520 3.9e-51 UPF0565 protein C2orf69 homolog OS=Mus musculus PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23081 BF_2 24.45 0.78 1602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23083 BF_2 38.26 0.74 2442 675380592 KFM73494.1 157 9.9e-08 hypothetical protein X975_07201, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23086 BF_2 23.11 1.00 1254 762146544 XP_011456572.1 230 1.7e-16 PREDICTED: uncharacterized protein LOC105348724 [Crassostrea gigas]>gi|405962723|gb|EKC28372.1| hypothetical protein CGI_10023755 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23087 BF_2 23.55 0.43 2569 675380592 KFM73494.1 157 1.0e-07 hypothetical protein X975_07201, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23089 BF_2 13.92 0.38 1813 762146544 XP_011456572.1 232 1.5e-16 PREDICTED: uncharacterized protein LOC105348724 [Crassostrea gigas]>gi|405962723|gb|EKC28372.1| hypothetical protein CGI_10023755 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23094 BF_2 204.57 4.42 2225 642921483 XP_008192888.1 2007 2.7e-222 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY0 219 2.4e-16 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.23095 BF_2 26.98 1.30 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23097 BF_2 635.18 5.27 5326 270005284 EFA01732.1 1464 6.0e-159 hypothetical protein TcasGA2_TC007325 [Tribolium castaneum] -- -- -- -- -- K05694 PTPRB, PTPB receptor-type tyrosine-protein phosphatase beta http://www.genome.jp/dbget-bin/www_bget?ko:K05694 P35992 618 3.1e-62 Tyrosine-protein phosphatase 10D OS=Drosophila melanogaster GN=Ptp10D PE=1 SV=4 PF00102//PF00041//PF00782 Protein-tyrosine phosphatase//Fibronectin type III domain//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0005515//GO:0008138//GO:0004725 protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG0791 Protein tyrosine phosphatase, contains fn3 domain Cluster-8309.23100 BF_2 73.31 0.56 5776 270008606 EFA05054.1 3313 0.0e+00 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 899 8.8e-95 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00665//PF00098//PF13683 Integrase core domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.23103 BF_2 11.89 0.59 1129 58385276 XP_313828.2 277 5.5e-22 AGAP004528-PA [Anopheles gambiae str. PEST]>gi|55240904|gb|EAA09295.2| AGAP004528-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.23106 BF_2 144.00 95.48 345 189238541 XP_001812788.1 189 2.7e-12 PREDICTED: uncharacterized protein LOC100142146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15184 Mitochondrial import receptor subunit TOM6 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.23109 BF_2 4.00 0.48 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.2311 BF_2 90.00 17.04 508 557745702 AHA33381.1 572 1.5e-56 odorant-binding protein 3 [Batocera horsfieldi] 557745701 KC461117.1 369 0 Batocera horsfieldi odorant-binding protein 3 (obp3) mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.23113 BF_2 674.40 12.42 2559 546684133 ERL93838.1 1454 4.2e-158 hypothetical protein D910_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IUS5 505 1.9e-49 Epoxide hydrolase 4 OS=Homo sapiens GN=EPHX4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4178 Soluble epoxide hydrolase Cluster-8309.23115 BF_2 50.31 1.07 2246 91089979 XP_973921.1 1248 2.8e-134 PREDICTED: uncharacterized protein LOC662748 isoform X2 [Tribolium castaneum]>gi|270013543|gb|EFA09991.1| hypothetical protein TcasGA2_TC012158 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05191 Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017 adenylate kinase activity -- -- -- -- Cluster-8309.23117 BF_2 14.00 12.14 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02939 UcrQ family GO:0015992//GO:0006119//GO:0006118 proton transport//oxidative phosphorylation//obsolete electron transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.23120 BF_2 3.00 0.73 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23121 BF_2 199.26 12.69 944 646708588 KDR14837.1 1260 4.8e-136 DNA-directed RNA polymerase II subunit RPB3 [Zootermopsis nevadensis] 751216889 XM_011163108.1 177 1.68512e-85 PREDICTED: Solenopsis invicta DNA-directed RNA polymerase II subunit RPB3 (LOC105196940), mRNA K03011 RPB3, POLR2C DNA-directed RNA polymerase II subunit RPB3 http://www.genome.jp/dbget-bin/www_bget?ko:K03011 P19387 1059 4.0e-114 DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens GN=POLR2C PE=1 SV=2 PF01000//PF01193 RNA polymerase Rpb3/RpoA insert domain//RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0046983//GO:0003899 protein dimerization activity//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG1522 RNA polymerase II, subunit POLR2C/RPB3 Cluster-8309.23123 BF_2 115.76 3.09 1856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23125 BF_2 163.83 1.11 6489 642936252 XP_008198368.1 1210 2.1e-129 PREDICTED: titin-like isoform X1 [Tribolium castaneum]>gi|642936254|ref|XP_008198369.1| PREDICTED: titin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF03606 Chitin binding Peritrophin-A domain//C4-dicarboxylate anaerobic carrier GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.23127 BF_2 10.00 1.65 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23129 BF_2 53.26 2.39 1220 270008834 EFA05282.1 836 9.1e-87 hypothetical protein TcasGA2_TC015439 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02599 388 3.3e-36 Calmodulin OS=Dictyostelium discoideum GN=calA PE=1 SV=3 PF12763//PF13202//PF13499//PF13405//PF10591//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.23130 BF_2 165.00 3.37 2335 91094371 XP_970701.1 602 2.4e-59 PREDICTED: nicotinamide riboside kinase 1 [Tribolium castaneum]>gi|270014938|gb|EFA11386.1| hypothetical protein TcasGA2_TC011546 [Tribolium castaneum] -- -- -- -- -- K10524 NRK1_2 nicotinamide/nicotinate riboside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K10524 Q9NWW6 308 1.2e-26 Nicotinamide riboside kinase 1 OS=Homo sapiens GN=NMRK1 PE=1 SV=1 PF00485//PF08303 Phosphoribulokinase / Uridine kinase family//tRNA ligase kinase domain GO:0008152//GO:0006388 metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0003972//GO:0005524//GO:0016301 RNA ligase (ATP) activity//ATP binding//kinase activity -- -- -- -- Cluster-8309.23133 BF_2 20.76 0.34 2840 91089769 XP_967094.1 1002 1.2e-105 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 3.8e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.23135 BF_2 430.74 4.70 4125 642930684 XP_008199986.1 1049 6.2e-111 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|642930686|ref|XP_008199987.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 [Tribolium castaneum]>gi|270012673|gb|EFA09121.1| hypothetical protein TcasGA2_TC015981 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AWG9 257 1.7e-20 Uncharacterized protein CG5098 OS=Drosophila melanogaster GN=CG5098 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23138 BF_2 359.38 24.37 904 91076494 XP_972946.1 288 2.4e-23 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 183 1.5e-12 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23139 BF_2 10.00 0.73 858 270001170 EEZ97617.1 138 5.5e-06 hypothetical protein TcasGA2_TC012951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2314 BF_2 15.00 0.35 2098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02472 Biopolymer transport protein ExbD/TolR GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.23140 BF_2 137.39 1.55 3998 642910771 XP_008193403.1 2225 2.6e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00620//PF10297 RhoGAP domain//Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.23141 BF_2 74.96 1.13 3058 642910771 XP_008193403.1 2110 4.3e-234 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0Q5 310 9.2e-27 Rho GTPase-activating protein 18 OS=Mus musculus GN=Arhgap18 PE=2 SV=1 PF10297//PF00620 Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.23144 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23147 BF_2 311.79 1.75 7720 642916594 XP_008191822.1 3184 0.0e+00 PREDICTED: alpha-catulin isoform X2 [Tribolium castaneum] 642916593 XM_008193600.1 726 0 PREDICTED: Tribolium castaneum alpha-catulin (LOC658111), transcript variant X2, mRNA -- -- -- -- Q9UBT7 1215 2.7e-131 Alpha-catulin OS=Homo sapiens GN=CTNNAL1 PE=1 SV=2 PF01044 Vinculin family GO:0007155 cell adhesion GO:0051015 actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.23148 BF_2 16.00 0.88 1048 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23150 BF_2 20.00 9.78 370 642937868 XP_008200332.1 147 2.2e-07 PREDICTED: uncharacterized protein LOC661294 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.23151 BF_2 157.84 2.37 3070 573875180 XP_006625928.1 321 1.2e-26 PREDICTED: serine/threonine-protein kinase Nek2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O35942 287 4.3e-24 Serine/threonine-protein kinase Nek2 OS=Mus musculus GN=Nek2 PE=1 SV=2 PF08040//PF00800//PF07714//PF00069 MNLL subunit//Prephenate dehydratase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0000162//GO:0006571//GO:0006118//GO:0009094 protein phosphorylation//tryptophan biosynthetic process//tyrosine biosynthetic process//obsolete electron transport//L-phenylalanine biosynthetic process GO:0004664//GO:0003954//GO:0005524//GO:0004672 prephenate dehydratase activity//NADH dehydrogenase activity//ATP binding//protein kinase activity GO:0005739 mitochondrion -- -- Cluster-8309.23153 BF_2 75.08 0.94 3622 478257569 ENN77723.1 263 7.5e-20 hypothetical protein YQE_05794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23154 BF_2 100.00 5.18 1094 332374870 AEE62576.1 906 6.2e-95 unknown [Dendroctonus ponderosae]>gi|478262466|gb|ENN81137.1| hypothetical protein YQE_02504, partial [Dendroctonus ponderosae]>gi|546672779|gb|ERL84535.1| hypothetical protein D910_01965 [Dendroctonus ponderosae] -- -- -- -- -- K10847 XPA DNA-repair protein complementing XP-A cells http://www.genome.jp/dbget-bin/www_bget?ko:K10847 P28518 596 2.3e-60 DNA repair protein complementing XP-A cells homolog OS=Drosophila melanogaster GN=Xpac PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4017 DNA excision repair protein XPA/XPAC/RAD14 Cluster-8309.23156 BF_2 221.00 3.34 3052 270004396 EFA00844.1 370 2.5e-32 hypothetical protein TcasGA2_TC003732 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.23157 BF_2 19.00 0.59 1642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23159 BF_2 8.90 0.32 1437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23161 BF_2 27.00 3.26 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23162 BF_2 213.97 9.06 1275 91079458 XP_966537.1 882 4.4e-92 PREDICTED: SAP30-binding protein [Tribolium castaneum]>gi|270004398|gb|EFA00846.1| hypothetical protein TcasGA2_TC003747 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02614 375 1.1e-34 SAP30-binding protein OS=Mus musculus GN=Sap30bp PE=2 SV=2 PF07818 HCNGP-like protein GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.23163 BF_2 63.00 4.00 946 642927012 XP_008195103.1 342 1.3e-29 PREDICTED: RNA polymerase II-associated protein 3 [Tribolium castaneum]>gi|270010040|gb|EFA06488.1| hypothetical protein TcasGA2_TC009385 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKQ3 201 1.2e-14 RNA polymerase II-associated protein 3 OS=Gallus gallus GN=RPAP3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23167 BF_2 258.61 2.01 5670 189237519 XP_973030.2 3595 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.3e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF05485//PF03470//PF01667//PF13465 THAP domain//XS zinc finger domain//Ribosomal protein S27//Zinc-finger double domain GO:0042254//GO:0031047//GO:0006412 ribosome biogenesis//gene silencing by RNA//translation GO:0046872//GO:0003735//GO:0003676 metal ion binding//structural constituent of ribosome//nucleic acid binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.23168 BF_2 25.12 0.41 2873 546681849 ERL91864.1 1415 1.6e-153 hypothetical protein D910_09188, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6N043 215 9.0e-16 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF01667//PF13465 Ribosomal protein S27//Zinc-finger double domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0046872//GO:0003735 metal ion binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.23169 BF_2 396.42 2.83 6141 189237519 XP_973030.2 3595 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.5e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF01667//PF03470//PF09367//PF13465//PF05485 Ribosomal protein S27//XS zinc finger domain//CpeS-like protein//Zinc-finger double domain//THAP domain GO:0031047//GO:0017009//GO:0042254//GO:0006412 gene silencing by RNA//protein-phycocyanobilin linkage//ribosome biogenesis//translation GO:0003735//GO:0003676//GO:0046872 structural constituent of ribosome//nucleic acid binding//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.23172 BF_2 102.77 4.20 1310 642932088 XP_975105.3 1247 2.1e-134 PREDICTED: acid phosphatase-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DH46 243 2.3e-19 2-phosphoxylose phosphatase 1 OS=Danio rerio GN=pxylp1 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.23173 BF_2 17.92 0.35 2410 546673515 ERL85101.1 1241 2.0e-133 hypothetical protein D910_02523 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KNA0 841 1.9e-88 Dymeclin OS=Drosophila melanogaster GN=CG8230 PE=1 SV=1 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG2225 Proteins containing regions of low-complexity Cluster-8309.23174 BF_2 131.70 0.96 6032 478255769 ENN75978.1 183 2.4e-10 hypothetical protein YQE_07511, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00816//PF04905//PF07544//PF02179//PF07517 H-NS histone family//NAB conserved region 2 (NCD2)//RNA polymerase II transcription mediator complex subunit 9//BAG domain//SecA DEAD-like domain GO:0017038//GO:0006357//GO:0045892//GO:0006355 protein import//regulation of transcription from RNA polymerase II promoter//negative regulation of transcription, DNA-templated//regulation of transcription, DNA-templated GO:0001104//GO:0003677//GO:0005524//GO:0051087 RNA polymerase II transcription cofactor activity//DNA binding//ATP binding//chaperone binding GO:0005634//GO:0016592//GO:0005622//GO:0016020 nucleus//mediator complex//intracellular//membrane -- -- Cluster-8309.23175 BF_2 43.16 1.27 1714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00260 Protamine P1 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.23177 BF_2 110.91 4.76 1261 270011665 EFA08113.1 656 7.0e-66 hypothetical protein TcasGA2_TC005717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IHQ9 220 1.0e-16 2-phosphoxylose phosphatase 1 OS=Xenopus tropicalis GN=pxylp1 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3672 Histidine acid phosphatase Cluster-8309.23182 BF_2 11.00 4.85 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23184 BF_2 15.00 0.68 1215 270015672 EFA12120.1 178 1.8e-10 hypothetical protein TcasGA2_TC002266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23185 BF_2 52.12 0.34 6700 270004778 EFA01226.1 1771 1.9e-194 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1242 1.7e-134 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683//PF06657//PF12513 Integrase core domain//Integrase core domain//Centrosome microtubule-binding domain of Cep57//Mitochondrial degradasome RNA helicase subunit C terminal GO:0015074 DNA integration GO:0016817//GO:0008017 hydrolase activity, acting on acid anhydrides//microtubule binding GO:0045298 tubulin complex KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.23187 BF_2 465.00 23.96 1099 91077040 XP_967879.1 577 8.8e-57 PREDICTED: signal recognition particle 19 kDa protein [Tribolium castaneum]>gi|270001745|gb|EEZ98192.1| hypothetical protein TcasGA2_TC000621 [Tribolium castaneum] -- -- -- -- -- K03105 SRP19 signal recognition particle subunit SRP19 http://www.genome.jp/dbget-bin/www_bget?ko:K03105 P49963 413 3.8e-39 Signal recognition particle 19 kDa protein OS=Drosophila melanogaster GN=Srp19 PE=2 SV=2 PF01922 SRP19 protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle KOG3198 Signal recognition particle, subunit Srp19 Cluster-8309.23188 BF_2 39.99 5.28 604 91078256 XP_970842.1 642 1.4e-64 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95373 394 3.3e-37 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0008536 protein transporter activity//Ran GTPase binding GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.23189 BF_2 117.48 1.71 3168 91078256 XP_970842.1 4084 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 817222787 XM_012431314.1 53 4.94719e-16 PREDICTED: Orussus abietinus importin-7 (LOC105703158), mRNA -- -- -- -- O95373 2647 9.8e-298 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008565//GO:0008536 protein transporter activity//Ran GTPase binding GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.23192 BF_2 1787.17 4.86 15660 642914247 XP_008201606.1 19704 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10506 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF00008//PF08717//PF07645 Cadherin domain//EGF-like domain//nsp8 replicase//Calcium-binding EGF domain GO:0006508//GO:0007156 proteolysis//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0004197//GO:0008242//GO:0016740//GO:0005515 calcium ion binding//cysteine-type endopeptidase activity//omega peptidase activity//transferase activity//protein binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.23195 BF_2 1.00 0.31 423 270016078 EFA12526.1 164 2.6e-09 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23199 BF_2 63.93 0.98 3025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23200 BF_2 17.00 2.16 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23201 BF_2 800.24 30.33 1391 859132824 AKO63323.1 955 1.6e-100 isopentenyl diphosphate delta isomerase [Leptinotarsa decemlineata] -- -- -- -- -- K01823 idi, IDI isopentenyl-diphosphate delta-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01823 P58044 571 2.3e-57 Isopentenyl-diphosphate Delta-isomerase 1 OS=Mus musculus GN=Idi1 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG0142 Isopentenyl pyrophosphate:dimethylallyl pyrophosphate isomerase Cluster-8309.23205 BF_2 284.00 5.88 2308 546672651 ERL84447.1 2083 4.3e-231 hypothetical protein D910_01879 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGZ1 1646 8.4e-182 CDK5RAP1-like protein OS=Drosophila melanogaster GN=CG6345 PE=2 SV=1 PF00919//PF04055 Uncharacterized protein family UPF0004//Radical SAM superfamily GO:0009451 RNA modification GO:0051539//GO:0003824//GO:0051536 4 iron, 4 sulfur cluster binding//catalytic activity//iron-sulfur cluster binding -- -- KOG2492 CDK5 activator-binding protein Cluster-8309.23208 BF_2 452.69 5.04 4041 642937864 XP_008200330.1 2824 0.0e+00 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEP1 1762 5.2e-195 Protein FAM91A1 OS=Danio rerio GN=fam91a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.23214 BF_2 2.00 2.06 317 642926860 XP_971810.2 177 6.1e-11 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17035 125 2.7e-06 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF02150//PF00130//PF13465//PF00096//PF07649 RNA polymerases M/15 Kd subunit//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type//C1-like domain GO:0006206//GO:0035556//GO:0055114//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//intracellular signal transduction//oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process GO:0046872//GO:0047134//GO:0003899//GO:0003677 metal ion binding//protein-disulfide reductase activity//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.23215 BF_2 4.00 0.62 556 260810939 XP_002600180.1 249 4.8e-19 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q8VIG1 152 3.5e-09 RE1-silencing transcription factor OS=Mus musculus GN=Rest PE=1 SV=2 PF07649//PF00628//PF00130//PF13465//PF00096 C1-like domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0047134//GO:0046872//GO:0005515 protein-disulfide reductase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.23216 BF_2 1509.72 10.52 6292 300394168 ADK11710.1 1641 2.1e-179 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P91885 919 4.6e-97 Aminopeptidase N OS=Manduca sexta GN=APN2 PE=1 SV=2 PF01433//PF03100 Peptidase family M1//CcmE GO:0017003//GO:0017004 protein-heme linkage//cytochrome complex assembly GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.23217 BF_2 47.70 0.31 6785 300394168 ADK11710.1 1641 2.3e-179 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P91885 919 4.9e-97 Aminopeptidase N OS=Manduca sexta GN=APN2 PE=1 SV=2 PF01433//PF03100 Peptidase family M1//CcmE GO:0017004//GO:0017003 cytochrome complex assembly//protein-heme linkage GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.23218 BF_2 332.58 2.38 6128 300394168 ADK11710.1 1638 4.6e-179 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P91885 919 4.5e-97 Aminopeptidase N OS=Manduca sexta GN=APN2 PE=1 SV=2 PF01433//PF03100 Peptidase family M1//CcmE GO:0017003//GO:0017004 protein-heme linkage//cytochrome complex assembly GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.23221 BF_2 28.65 0.33 3956 642920124 XP_008192216.1 1477 1.4e-160 PREDICTED: microtubule-associated protein futsch isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q869E1 146 1.2e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 PF01537 Herpesvirus glycoprotein D/GG/GX domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.23224 BF_2 87.40 3.10 1468 282165774 NP_001164128.1 1052 9.8e-112 cardiolipin synthase 1 [Tribolium castaneum] -- -- -- -- -- K08744 CRLS cardiolipin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K08744 Q8MZC4 652 9.8e-67 Probable cardiolipin synthase (CMP-forming) OS=Drosophila melanogaster GN=CLS PE=2 SV=1 PF01066//PF01896//PF01017//PF16818 CDP-alcohol phosphatidyltransferase//Eukaryotic and archaeal DNA primase small subunit//STAT protein, all-alpha domain//Protein SLM4 GO:0016237//GO:0006351//GO:0007165//GO:0008654//GO:0006269//GO:0006355 lysosomal microautophagy//transcription, DNA-templated//signal transduction//phospholipid biosynthetic process//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated GO:0003896//GO:0016780//GO:0003700//GO:0004871 DNA primase activity//phosphotransferase activity, for other substituted phosphate groups//transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005667//GO:0005657//GO:0005730//GO:0016020//GO:0034448 transcription factor complex//replication fork//nucleolus//membrane//EGO complex KOG1617 CDP-alcohol phosphatidyltransferase/Phosphatidylglycerol-phosphate synthase Cluster-8309.23225 BF_2 44.00 0.76 2704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23228 BF_2 48.06 0.32 6624 478251279 ENN71750.1 2240 7.8e-249 hypothetical protein YQE_11570, partial [Dendroctonus ponderosae]>gi|478251283|gb|ENN71754.1| hypothetical protein YQE_11574, partial [Dendroctonus ponderosae] -- -- -- -- -- K14809 DDX55, SPB4 ATP-dependent RNA helicase DDX55/SPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K14809 Q9VHU1 1497 4.6e-164 Probable ATP-dependent RNA helicase DDX55 homolog OS=Drosophila melanogaster GN=CG9630 PE=2 SV=1 PF04851//PF07544//PF00270 Type III restriction enzyme, res subunit//RNA polymerase II transcription mediator complex subunit 9//DEAD/DEAH box helicase GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0016787//GO:0003677//GO:0003676//GO:0005524 RNA polymerase II transcription cofactor activity//hydrolase activity//DNA binding//nucleic acid binding//ATP binding GO:0016592 mediator complex KOG0345 ATP-dependent RNA helicase Cluster-8309.23230 BF_2 205.94 1.39 6500 478251279 ENN71750.1 2240 7.6e-249 hypothetical protein YQE_11570, partial [Dendroctonus ponderosae]>gi|478251283|gb|ENN71754.1| hypothetical protein YQE_11574, partial [Dendroctonus ponderosae] -- -- -- -- -- K14809 DDX55, SPB4 ATP-dependent RNA helicase DDX55/SPB4 http://www.genome.jp/dbget-bin/www_bget?ko:K14809 Q9VHU1 1497 4.5e-164 Probable ATP-dependent RNA helicase DDX55 homolog OS=Drosophila melanogaster GN=CG9630 PE=2 SV=1 PF07544//PF00270//PF04851 RNA polymerase II transcription mediator complex subunit 9//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0003677//GO:0016787//GO:0003676//GO:0005524 RNA polymerase II transcription cofactor activity//DNA binding//hydrolase activity//nucleic acid binding//ATP binding GO:0016592 mediator complex KOG0345 ATP-dependent RNA helicase Cluster-8309.23233 BF_2 12.00 0.58 1150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23234 BF_2 23.24 0.43 2547 91089737 XP_975124.1 1653 3.5e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.5e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF04506//PF01384 Rft protein//Phosphate transporter family GO:0006817//GO:0006869 phosphate ion transport//lipid transport GO:0005315//GO:0005319 inorganic phosphate transmembrane transporter activity//lipid transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.23235 BF_2 16.71 0.64 1373 478251391 ENN71857.1 259 8.3e-20 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 P54726 159 1.3e-09 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 PF09280//PF00995 XPC-binding domain//Sec1 family GO:0043161//GO:0006281//GO:0016192//GO:0006289//GO:0006904 proteasome-mediated ubiquitin-dependent protein catabolic process//DNA repair//vesicle-mediated transport//nucleotide-excision repair//vesicle docking involved in exocytosis GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.23236 BF_2 12.89 3.56 438 546673559 ERL85134.1 168 9.4e-10 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23237 BF_2 6.09 1.09 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23242 BF_2 1.25 0.32 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23244 BF_2 67.00 1.82 1827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23245 BF_2 47.00 1.02 2223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23246 BF_2 745.01 7.70 4337 642924799 XP_008194045.1 2141 1.5e-237 PREDICTED: aspartate--tRNA ligase, mitochondrial [Tribolium castaneum] 701168938 CP007711.1 38 1.48102e-07 Candidatus Mycoplasma girerdii strain VCU_M1, complete genome K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 Q3KRD0 1437 2.7e-157 Aspartate--tRNA ligase, mitochondrial OS=Rattus norvegicus GN=Dars2 PE=1 SV=1 PF07500//PF01096//PF01336//PF00152//PF07700//PF01409//PF08711 Transcription factor S-II (TFIIS), central domain//Transcription factor S-II (TFIIS)//OB-fold nucleic acid binding domain//tRNA synthetases class II (D, K and N)//Haem-NO-binding//tRNA synthetases class II core domain (F)//TFIIS helical bundle-like domain GO:0006351//GO:0006418//GO:0043039 transcription, DNA-templated//tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0003677//GO:0005524//GO:0000049//GO:0003676//GO:0000166//GO:0008270//GO:0004812//GO:0020037 DNA binding//ATP binding//tRNA binding//nucleic acid binding//nucleotide binding//zinc ion binding//aminoacyl-tRNA ligase activity//heme binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG2411 Aspartyl-tRNA synthetase, mitochondrial Cluster-8309.23248 BF_2 84.67 1.40 2820 668458814 KFB46677.1 1068 2.6e-113 hypothetical protein ZHAS_00014689 [Anopheles sinensis] -- -- -- -- -- K13577 SLC25A10, DIC solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13577 Q9UBX3 826 1.2e-86 Mitochondrial dicarboxylate carrier OS=Homo sapiens GN=SLC25A10 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.23251 BF_2 33.51 0.88 1882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23252 BF_2 14.61 0.43 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23256 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23261 BF_2 205.12 3.72 2593 642935548 XP_008198054.1 622 1.3e-61 PREDICTED: caspase-7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55210 312 4.6e-27 Caspase-7 OS=Homo sapiens GN=CASP7 PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.23264 BF_2 280.06 1.71 7147 270003541 EEZ99988.1 3167 0.0e+00 hypothetical protein TcasGA2_TC002791 [Tribolium castaneum] 805798528 XM_012288489.1 131 4.90128e-59 PREDICTED: Megachile rotundata calponin homology domain-containing protein DDB_G0272472 (LOC100882081), transcript variant X2, mRNA K11478 JARID2, JMJ protein Jumonji http://www.genome.jp/dbget-bin/www_bget?ko:K11478 Q5F363 922 2.3e-97 Protein Jumonji OS=Gallus gallus GN=JARID2 PE=2 SV=1 PF02861//PF01388 Clp amino terminal domain, pathogenicity island component//ARID/BRIGHT DNA binding domain GO:0019538 protein metabolic process GO:0003677 DNA binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.23268 BF_2 3.00 4.78 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23273 BF_2 5.05 0.34 905 91084289 XP_967046.1 528 3.5e-51 PREDICTED: ras-related protein Rab-35 [Tribolium castaneum]>gi|270008813|gb|EFA05261.1| hypothetical protein TcasGA2_TC015416 [Tribolium castaneum] 765118842 XM_004068360.2 35 1.39628e-06 PREDICTED: Oryzias latipes ras-related protein Rab-8A (LOC101161304), mRNA K07876 RAB35, RAB1C Ras-related protein Rab-35 http://www.genome.jp/dbget-bin/www_bget?ko:K07876 Q15286 488 6.3e-48 Ras-related protein Rab-35 OS=Homo sapiens GN=RAB35 PE=1 SV=1 PF08477//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0000166 GTP binding//nucleotide binding -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.23274 BF_2 122.56 5.12 1289 91089157 XP_973708.1 545 5.3e-53 PREDICTED: uncharacterized protein LOC662524 [Tribolium castaneum]>gi|270012450|gb|EFA08898.1| hypothetical protein TcasGA2_TC006599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0032222//GO:1903818//GO:0030431 regulation of synaptic transmission, cholinergic//positive regulation of voltage-gated potassium channel activity//sleep GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.23275 BF_2 109.88 0.65 7354 642935211 XP_008199691.1 1937 1.2e-213 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X1 [Tribolium castaneum] 642935210 XM_008201469.1 874 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X1, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 1441 1.6e-157 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.23276 BF_2 126.89 2.66 2283 91083931 XP_974830.1 838 1.0e-86 PREDICTED: N-acetylserotonin O-methyltransferase-like protein [Tribolium castaneum]>gi|270007966|gb|EFA04414.1| hypothetical protein TcasGA2_TC014714 [Tribolium castaneum] -- -- -- -- -- K06287 maf septum formation protein http://www.genome.jp/dbget-bin/www_bget?ko:K06287 O95671 336 6.7e-30 N-acetylserotonin O-methyltransferase-like protein OS=Homo sapiens GN=ASMTL PE=1 SV=3 PF02545 Maf-like protein -- -- -- -- GO:0005737 cytoplasm KOG1509 Predicted nucleic acid-binding protein ASMTL Cluster-8309.23278 BF_2 315.58 2.56 5448 642929679 XP_975498.3 2932 0.0e+00 PREDICTED: metastasis-associated protein MTA3 isoform X2 [Tribolium castaneum] 768415855 XM_011550194.1 183 4.62693e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1635 3.8e-180 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF00096//PF01426//PF00320//PF06152 Zinc finger, C2H2 type//BAH domain//GATA zinc finger//Phage minor capsid protein 2 GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003682//GO:0003700//GO:0043565//GO:0008270//GO:0005198 metal ion binding//chromatin binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding//structural molecule activity GO:0005667//GO:0000785//GO:0019028 transcription factor complex//chromatin//viral capsid KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.2328 BF_2 6.00 0.89 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23280 BF_2 100.38 0.71 6184 642929679 XP_975498.3 2932 0.0e+00 PREDICTED: metastasis-associated protein MTA3 isoform X2 [Tribolium castaneum] 768415855 XM_011550194.1 183 5.25617e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1635 4.3e-180 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF01426//PF00096//PF00320 BAH domain//Zinc finger, C2H2 type//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0003682//GO:0003700//GO:0043565//GO:0008270 metal ion binding//chromatin binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0000785 transcription factor complex//chromatin KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.23281 BF_2 620.21 11.34 2576 270009558 EFA06006.1 3202 0.0e+00 hypothetical protein TcasGA2_TC008832 [Tribolium castaneum] 768415855 XM_011550194.1 183 2.17308e-88 PREDICTED: Plutella xylostella metastasis-associated protein MTA1 (LOC105380604), mRNA K11660 MTA metastasis-associated protein MTA http://www.genome.jp/dbget-bin/www_bget?ko:K11660 Q13330 1641 3.6e-181 Metastasis-associated protein MTA1 OS=Homo sapiens GN=MTA1 PE=1 SV=2 PF00096//PF01426//PF00320 Zinc finger, C2H2 type//BAH domain//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003682//GO:0046872//GO:0003700 zinc ion binding//sequence-specific DNA binding//chromatin binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0000785//GO:0005667 chromatin//transcription factor complex KOG3554 Histone deacetylase complex, MTA1 component Cluster-8309.23282 BF_2 94.20 1.11 3843 642932696 XP_008196948.1 1875 9.5e-207 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17085//PF10473//PF02183//PF06367//PF06371 Unique cartilage matrix associated protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Homeobox associated leucine zipper//Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0016043//GO:0045667//GO:0030036//GO:0006355 cellular component organization//regulation of osteoblast differentiation//actin cytoskeleton organization//regulation of transcription, DNA-templated GO:0003779//GO:0045502//GO:0008134//GO:0017048//GO:0003700//GO:0042803//GO:0043565 actin binding//dynein binding//transcription factor binding//Rho GTPase binding//transcription factor activity, sequence-specific DNA binding//protein homodimerization activity//sequence-specific DNA binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.23283 BF_2 11.95 0.36 1665 642918006 XP_971827.2 216 9.7e-15 PREDICTED: N-alpha-acetyltransferase 60 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX8 178 1.0e-11 N-alpha-acetyltransferase 60 OS=Drosophila melanogaster GN=Naa60 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23285 BF_2 398.05 5.77 3174 91078790 XP_969765.1 2187 5.2e-243 PREDICTED: retinoblastoma-binding protein 5 [Tribolium castaneum]>gi|270003731|gb|EFA00179.1| hypothetical protein TcasGA2_TC003004 [Tribolium castaneum] 815929092 XM_003494688.2 345 2.36202e-178 PREDICTED: Bombus impatiens retinoblastoma-binding protein 5 homolog (LOC100746759), mRNA K14961 RBBP5, SWD1, CPS50 COMPASS component SWD1 http://www.genome.jp/dbget-bin/www_bget?ko:K14961 Q9VPH8 1867 2.7e-207 Retinoblastoma-binding protein 5 homolog OS=Drosophila melanogaster GN=Rbbp5 PE=1 SV=2 PF00400//PF01239//PF01459 WD domain, G-beta repeat//Protein prenyltransferase alpha subunit repeat//Eukaryotic porin GO:0018342//GO:0055085 protein prenylation//transmembrane transport GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity GO:0005741 mitochondrial outer membrane KOG1273 WD40 repeat protein Cluster-8309.23286 BF_2 41.00 3.34 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23289 BF_2 1.00 29.91 208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23292 BF_2 6.00 2.30 395 390362249 XP_001190749.2 261 1.4e-20 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 257 1.7e-21 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05396 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.23293 BF_2 11.00 1.62 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23295 BF_2 27.77 0.45 2875 642917947 XP_008198954.1 1422 2.4e-154 PREDICTED: SNF-related serine/threonine-protein kinase [Tribolium castaneum] 828210619 XM_004208630.2 127 3.27589e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1242 7.4e-135 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG4717 Serine/threonine protein kinase Cluster-8309.23298 BF_2 118.00 6.16 1089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23300 BF_2 529.00 28.05 1076 170047211 XP_001851125.1 538 2.9e-52 adrenodoxin [Culex quinquefasciatus]>gi|167869695|gb|EDS33078.1| adrenodoxin [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- P10109 372 2.1e-34 Adrenodoxin, mitochondrial OS=Homo sapiens GN=FDX1 PE=1 SV=1 PF00111 2Fe-2S iron-sulfur cluster binding domain GO:0006118 obsolete electron transport GO:0051537//GO:0009055//GO:0051536//GO:0046872 2 iron, 2 sulfur cluster binding//electron carrier activity//iron-sulfur cluster binding//metal ion binding -- -- KOG3309 Ferredoxin Cluster-8309.23302 BF_2 386.00 3.78 4554 189236491 XP_001815774.1 2020 1.7e-223 PREDICTED: gem-associated protein 5 [Tribolium castaneum]>gi|270005977|gb|EFA02425.1| hypothetical protein TcasGA2_TC008111 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEQ6 407 7.8e-38 Gem-associated protein 5 OS=Homo sapiens GN=GEMIN5 PE=1 SV=3 PF13176//PF00400//PF05409 Tetratricopeptide repeat//WD domain, G-beta repeat//Coronavirus endopeptidase C30 GO:0019082 viral protein processing GO:0005515 protein binding -- -- -- -- Cluster-8309.23305 BF_2 9.71 0.31 1613 546672794 ERL84550.1 614 6.6e-61 hypothetical protein D910_01979 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6Q0N3 406 3.6e-38 5'-nucleotidase domain-containing protein 2 OS=Rattus norvegicus GN=Nt5dc2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2470 Similar to IMP-GMP specific 5'-nucleotidase Cluster-8309.23307 BF_2 400.00 25.55 942 478254420 ENN74672.1 768 5.4e-79 hypothetical protein YQE_08789, partial [Dendroctonus ponderosae] -- -- -- -- -- K04569 CCS copper chaperone for superoxide dismutase http://www.genome.jp/dbget-bin/www_bget?ko:K04569 Q9WU84 567 4.5e-57 Copper chaperone for superoxide dismutase OS=Mus musculus GN=Ccs PE=2 SV=1 PF00080//PF00403 Copper/zinc superoxide dismutase (SODC)//Heavy-metal-associated domain GO:0006801//GO:0030001//GO:0055114 superoxide metabolic process//metal ion transport//oxidation-reduction process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.23308 BF_2 265.98 10.22 1376 546682572 ERL92495.1 1341 2.8e-145 hypothetical protein D910_09808 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 385 8.4e-36 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23309 BF_2 63.98 1.22 2480 546682572 ERL92495.1 750 1.7e-76 hypothetical protein D910_09808 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 219 2.7e-16 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23310 BF_2 14.00 0.36 1902 91076124 XP_969821.1 1149 7.2e-123 PREDICTED: protein tipE [Tribolium castaneum]>gi|270014713|gb|EFA11161.1| hypothetical protein TcasGA2_TC004765 [Tribolium castaneum] 462311136 APGK01047078.1 38 6.4309e-08 Dendroctonus ponderosae Seq01047088, whole genome shotgun sequence -- -- -- -- P48613 210 2.3e-15 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.23313 BF_2 25.07 0.36 3169 270014279 EFA10727.1 1613 1.9e-176 cappuccino [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 781 2.3e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.23318 BF_2 15.00 4.15 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2332 BF_2 17.00 0.43 1947 642927117 XP_008195144.1 1483 1.4e-161 PREDICTED: clavesin-2 isoform X1 [Tribolium castaneum] 642927118 XM_967037.3 161 2.77519e-76 PREDICTED: Tribolium castaneum clavesin-2 (LOC660834), transcript variant X2, mRNA -- -- -- -- A6JUQ6 313 2.6e-27 Clavesin-2 OS=Rattus norvegicus GN=Clvs2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23320 BF_2 10.00 1.05 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23323 BF_2 138.07 1.99 3196 642936222 XP_008198354.1 1070 1.8e-113 PREDICTED: glutamyl aminopeptidase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LQ0 675 4.6e-69 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.23326 BF_2 2.00 1.36 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF00580//PF04815 Diaphanous GTPase-binding Domain//UvrD/REP helicase N-terminal domain//Sec23/Sec24 helical domain GO:0006888//GO:0006886//GO:0030036 ER to Golgi vesicle-mediated transport//intracellular protein transport//actin cytoskeleton organization GO:0005524//GO:0003779//GO:0017048 ATP binding//actin binding//Rho GTPase binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.23329 BF_2 135.00 3.81 1770 189242034 XP_001807841.1 819 1.2e-84 PREDICTED: STI1-like protein [Tribolium castaneum]>gi|270015919|gb|EFA12367.1| hypothetical protein TcasGA2_TC002073 [Tribolium castaneum] -- -- -- -- -- K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q8ILC1 231 7.7e-18 STI1-like protein OS=Plasmodium falciparum (isolate 3D7) GN=PF14_0324 PE=3 SV=1 PF13176//PF13414//PF00515//PF13181//PF13371 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0548 Molecular co-chaperone STI1 Cluster-8309.23333 BF_2 33.23 0.42 3609 91083441 XP_969909.1 870 3.1e-90 PREDICTED: retinal homeobox protein Rx-B [Tribolium castaneum]>gi|270008142|gb|EFA04590.1| reversed polarity [Tribolium castaneum] -- -- -- -- -- K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 O42115 247 2.2e-19 Aristaless-related homeobox protein OS=Danio rerio GN=arx PE=2 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.23334 BF_2 200.78 2.89 3192 91083441 XP_969909.1 1199 1.9e-128 PREDICTED: retinal homeobox protein Rx-B [Tribolium castaneum]>gi|270008142|gb|EFA04590.1| reversed polarity [Tribolium castaneum] 462346959 APGK01034101.1 64 3.82655e-22 Dendroctonus ponderosae Seq01034111, whole genome shotgun sequence K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 O42115 218 4.5e-16 Aristaless-related homeobox protein OS=Danio rerio GN=arx PE=2 SV=1 PF00046//PF00487//PF05920//PF05478 Homeobox domain//Fatty acid desaturase//Homeobox KN domain//Prominin GO:0006629//GO:0006355 lipid metabolic process//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0016021 integral component of membrane KOG0490 Transcription factor, contains HOX domain Cluster-8309.23337 BF_2 177.38 5.33 1679 546681837 ERL91852.1 1147 1.1e-122 hypothetical protein D910_09177 [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 745 1.8e-77 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0750 Mitochondrial solute carrier protein Cluster-8309.23338 BF_2 29.03 0.36 3691 478251486 ENN71949.1 495 9.6e-47 hypothetical protein YQE_11383, partial [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 299 2.1e-25 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 PF00519 Papillomavirus helicase GO:0006260 DNA replication GO:0003677//GO:0004003//GO:0005524 DNA binding//ATP-dependent DNA helicase activity//ATP binding GO:0005657 replication fork KOG0750 Mitochondrial solute carrier protein Cluster-8309.23339 BF_2 184.55 2.27 3691 478251486 ENN71949.1 495 9.6e-47 hypothetical protein YQE_11383, partial [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 299 2.1e-25 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 PF00519 Papillomavirus helicase GO:0006260 DNA replication GO:0005524//GO:0003677//GO:0004003 ATP binding//DNA binding//ATP-dependent DNA helicase activity GO:0005657 replication fork KOG0750 Mitochondrial solute carrier protein Cluster-8309.23341 BF_2 153.26 9.97 930 642915536 XP_008190656.1 775 8.2e-80 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] 572317138 XM_006624115.1 117 3.74726e-52 PREDICTED: Apis dorsata uncharacterized LOC102679271 (LOC102679271), transcript variant X3, mRNA -- -- -- -- Q8IQC1 557 6.4e-56 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.23342 BF_2 40.00 18.17 377 751442604 XP_011195955.1 225 2.0e-16 PREDICTED: uncharacterized protein DDB_G0290301 isoform X1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q00690 147 9.0e-09 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23344 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23346 BF_2 13.81 0.46 1530 642939160 XP_969591.2 879 1.2e-91 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 625 1.4e-63 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.23347 BF_2 9.00 0.97 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23349 BF_2 54.34 0.42 5666 642920507 XP_008192379.1 5378 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 1224 1.8e-132 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.23352 BF_2 18.28 0.60 1557 478253719 ENN74018.1 930 1.5e-97 hypothetical protein YQE_09408, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 183 2.5e-12 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0161 Myosin class II heavy chain Cluster-8309.23358 BF_2 83.71 1.10 3480 752892475 XP_011264324.1 1492 2.2e-162 PREDICTED: POU domain, class 6, transcription factor 2 isoform X2 [Camponotus floridanus] 817056495 XM_012413689.1 172 3.83588e-82 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 693 4.1e-71 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00046//PF00157 Homeobox domain//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.23363 BF_2 65.85 0.49 5942 270007165 EFA03613.1 1428 1.0e-154 hypothetical protein TcasGA2_TC013701 [Tribolium castaneum] 642922589 XM_008195018.1 320 3.51033e-164 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X6, mRNA -- -- -- -- P55197 839 8.2e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG0956 PHD finger protein AF10 Cluster-8309.23364 BF_2 66.00 4.74 870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0005102//GO:0030674 receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.23366 BF_2 94.42 1.50 2929 546680487 ERL90753.1 1413 2.7e-153 hypothetical protein D910_08100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Z136 313 4.0e-27 Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 PF06005//PF02465//PF11380 Protein of unknown function (DUF904)//Flagellar hook-associated protein 2 N-terminus//Stealth protein CR2, conserved region 2 GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0009424//GO:0005737 bacterial-type flagellum hook//cytoplasm KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.23368 BF_2 7.00 0.45 940 642923667 XP_008193834.1 746 1.9e-76 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 378 3.7e-35 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF04923//PF04159//PF05656 ABC transporter transmembrane region//Ninjurin//NB glycoprotein//Protein of unknown function (DUF805) GO:0042246//GO:0006810//GO:0007155//GO:0055085 tissue regeneration//transport//cell adhesion//transmembrane transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.23369 BF_2 14.18 0.35 1999 546673062 ERL84739.1 834 2.5e-86 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 389 4.2e-36 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF01764//PF07859//PF02230//PF10503//PF11112 Lipase (class 3)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Esterase PHB depolymerase//Pyocin activator protein PrtN GO:0006629//GO:0008152//GO:0006355 lipid metabolic process//metabolic process//regulation of transcription, DNA-templated GO:0016787 hydrolase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.23371 BF_2 5.00 1.64 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23374 BF_2 4.00 162.12 202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23376 BF_2 6.00 0.37 969 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14735 HAUS augmin-like complex subunit 4 GO:0051225 spindle assembly -- -- GO:0070652 HAUS complex -- -- Cluster-8309.23377 BF_2 25.83 1.20 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23378 BF_2 114.73 3.02 1876 91078940 XP_973987.1 1302 1.3e-140 PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|642916209|ref|XP_008190931.1| PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|270003691|gb|EFA00139.1| hypothetical protein TcasGA2_TC002960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWP6 536 3.5e-53 Motile sperm domain-containing protein 2 OS=Mus musculus GN=Mospd2 PE=1 SV=2 -- -- -- -- GO:0005198 structural molecule activity -- -- KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-8309.23379 BF_2 10.00 1.79 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23381 BF_2 10.89 0.32 1733 478255527 ENN75744.1 1035 1.1e-109 hypothetical protein YQE_07704, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23382 BF_2 12.92 0.38 1712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23385 BF_2 133.00 22.44 535 642915958 XP_008190827.1 447 5.1e-42 PREDICTED: probable small nuclear ribonucleoprotein E [Tribolium castaneum] 637295421 XM_003220319.2 80 7.75229e-32 PREDICTED: Anolis carolinensis small nuclear ribonucleoprotein polypeptide E (snrpe), mRNA K11097 SNRPE, SME small nuclear ribonucleoprotein E http://www.genome.jp/dbget-bin/www_bget?ko:K11097 Q9VLV5 390 8.5e-37 Probable small nuclear ribonucleoprotein E OS=Drosophila melanogaster GN=SmE PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1774 Small nuclear ribonucleoprotein E Cluster-8309.23395 BF_2 13.17 1.49 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23396 BF_2 6.29 0.44 879 668448475 KFB38130.1 163 7.2e-09 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23397 BF_2 63.68 0.56 5041 283046724 NP_001164308.1 1952 1.5e-215 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 751 1.1e-77 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF00023//PF13606//PF00520//PF08727 Ankyrin repeat//Ankyrin repeat//Ion transport protein//Poliovirus 3A protein like GO:0006508//GO:0006811//GO:0055085//GO:0006144 proteolysis//ion transport//transmembrane transport//purine nucleobase metabolic process GO:0005216//GO:0003968//GO:0017111//GO:0004197//GO:0005515 ion channel activity//RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//protein binding GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex -- -- Cluster-8309.23399 BF_2 4.00 2.93 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23400 BF_2 348.69 1.85 8188 817053828 XP_012264100.1 1826 9.8e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935876 XR_511652.1 647 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X4, misc_RNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 Q9UBE8 1597 1.4e-175 Serine/threonine-protein kinase NLK OS=Homo sapiens GN=NLK PE=1 SV=2 PF04505//PF07714//PF00069//PF06293 Interferon-induced transmembrane protein//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009607//GO:0006468 response to biotic stimulus//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.23402 BF_2 7.98 0.46 1009 270002181 EEZ98628.1 244 3.3e-18 hypothetical protein TcasGA2_TC001151, partial [Tribolium castaneum] -- -- -- -- -- K18168 SDHAF2, SDH5 succinate dehydrogenase assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18168 B4GDB3 209 1.6e-15 Succinate dehydrogenase assembly factor 2-A, mitochondrial OS=Drosophila persimilis GN=GL10881 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3326 Uncharacterized conserved protein Cluster-8309.23403 BF_2 913.00 25.26 1799 478255147 ENN75377.1 1545 8.2e-169 hypothetical protein YQE_08152, partial [Dendroctonus ponderosae]>gi|546680094|gb|ERL90435.1| hypothetical protein D910_07784 [Dendroctonus ponderosae] 723577947 XM_010310830.1 36 7.85995e-07 PREDICTED: Balearica regulorum gibbericeps membrane bound O-acyltransferase domain containing 2 (MBOAT2), partial mRNA K13517 MBOAT1_2 lysophospholipid acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13517 Q8BH98 887 6.7e-94 Lysophospholipid acyltransferase 1 OS=Mus musculus GN=Mboat1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2704 Predicted membrane protein Cluster-8309.23404 BF_2 162.00 3.64 2149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23405 BF_2 54.00 1.73 1593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23406 BF_2 37.83 0.35 4778 642930494 XP_008196427.1 2252 2.3e-250 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 3.7e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF01528//PF02985 Herpesvirus glycoprotein M//HEAT repeat -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.23408 BF_2 298.13 1.52 8517 642916934 XP_008199560.1 3515 0.0e+00 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] 642916933 XM_008201338.1 374 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase HSL1 (LOC660568), mRNA K08853 AAK AP2-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08853 F1MH24 1145 3.9e-123 AP2-associated protein kinase 1 OS=Bos taurus GN=AAK1 PE=1 SV=2 PF00069//PF07714//PF07578 Protein kinase domain//Protein tyrosine kinase//Lipid A Biosynthesis N-terminal domain GO:0009245//GO:0006468 lipid A biosynthetic process//protein phosphorylation GO:0005524//GO:0008915//GO:0004672 ATP binding//lipid-A-disaccharide synthase activity//protein kinase activity -- -- KOG1989 ARK protein kinase family Cluster-8309.23410 BF_2 146.00 13.17 751 91078152 XP_973842.1 707 5.1e-72 PREDICTED: histone deacetylase complex subunit SAP18 [Tribolium castaneum]>gi|270001369|gb|EEZ97816.1| hypothetical protein TcasGA2_TC000183 [Tribolium castaneum] -- -- -- -- -- K14324 SAP18 histone deacetylase complex subunit SAP18 http://www.genome.jp/dbget-bin/www_bget?ko:K14324 Q9VEX9 422 2.3e-40 Histone deacetylase complex subunit SAP18 OS=Drosophila melanogaster GN=Bin1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3391 Transcriptional co-repressor component Cluster-8309.23414 BF_2 582.15 15.17 1892 642928346 XP_008195544.1 1402 3.3e-152 PREDICTED: neuronal acetylcholine receptor subunit beta-3-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02709 243 3.4e-19 Acetylcholine receptor subunit alpha OS=Bos taurus GN=CHRNA1 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.23422 BF_2 17.98 0.32 2640 91093989 XP_970414.1 836 2.0e-86 PREDICTED: golgin-45 [Tribolium castaneum]>gi|270016104|gb|EFA12552.1| hypothetical protein TcasGA2_TC001960 [Tribolium castaneum] 801398575 XM_012204360.1 66 2.44242e-23 PREDICTED: Atta cephalotes uncharacterized LOC105622954 (LOC105622954), mRNA -- -- -- -- Q9H2G9 232 8.8e-18 Golgin-45 OS=Homo sapiens GN=BLZF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4074 Leucine zipper nuclear factor Cluster-8309.23425 BF_2 65.74 2.85 1253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23426 BF_2 286.10 3.46 3748 642921579 XP_008192431.1 1070 2.1e-113 PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum]>gi|642921581|ref|XP_008192432.1| PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum] 642921580 XM_008194210.1 260 4.98286e-131 PREDICTED: Tribolium castaneum MOB kinase activator-like 2 (LOC657020), transcript variant X2, mRNA -- -- -- -- Q2LZ59 929 1.9e-98 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.23427 BF_2 499.35 20.58 1302 237820629 NP_001153782.1 1172 1.1e-125 transmembrane protein 120B [Tribolium castaneum]>gi|270004540|gb|EFA00988.1| hypothetical protein TcasGA2_TC003901 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9U1M2 1013 1.2e-108 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane KOG4758 Predicted membrane protein Cluster-8309.23433 BF_2 12.04 0.38 1603 642923229 XP_008193666.1 370 1.3e-32 PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X2 [Tribolium castaneum] 642923230 XM_008195445.1 143 2.30831e-66 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X3, mRNA K04494 CHD8, HELSNF1 chromodomain helicase DNA binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K04494 Q9JIX5 196 8.0e-14 Chromodomain-helicase-DNA-binding protein 8 OS=Rattus norvegicus GN=Chd8 PE=1 SV=2 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0016818//GO:0005524//GO:0003676 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.23434 BF_2 2.00 0.47 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23435 BF_2 84.36 4.77 1027 270003204 EEZ99651.1 607 2.7e-60 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G3MWR8 373 1.5e-34 Protein-methionine sulfoxide oxidase MICAL3 OS=Bos taurus GN=MICAL3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23437 BF_2 64.39 0.99 3021 642927195 XP_008195175.1 2065 7.0e-229 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75445 130 6.8e-06 Usherin OS=Homo sapiens GN=USH2A PE=1 SV=3 PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23440 BF_2 215.56 1.06 8818 642916561 XP_008191701.1 2302 6.7e-256 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] 642916712 XM_001813000.2 329 5.18072e-169 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q5T2T1 1155 2.8e-124 MAGUK p55 subfamily member 7 OS=Homo sapiens GN=MPP7 PE=1 SV=1 PF00651//PF14604//PF00018//PF00595//PF05225//PF13180 BTB/POZ domain//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF)//helix-turn-helix, Psq domain//PDZ domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.23441 BF_2 91.57 0.94 4378 642914301 XP_008201628.1 179 5.0e-10 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X1 [Tribolium castaneum] 462293333 APGK01053470.1 36 1.93408e-06 Dendroctonus ponderosae Seq01053480, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02723//PF03938//PF04037//PF06374 Non-structural protein NS3/Small envelope protein E//Outer membrane protein (OmpH-like)//Domain of unknown function (DUF382)//NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006120//GO:0006744//GO:0006814//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//proton transport GO:0051082//GO:0008137 unfolded protein binding//NADH dehydrogenase (ubiquinone) activity GO:0005743//GO:0005634//GO:0016020 mitochondrial inner membrane//nucleus//membrane -- -- Cluster-8309.23442 BF_2 266.61 5.05 2497 642915726 XP_008190777.1 1386 3.1e-150 PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum]>gi|642915728|ref|XP_008190778.1| PREDICTED: uncharacterized protein LOC103312284 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 Q9NWF9 442 3.7e-42 E3 ubiquitin-protein ligase RNF216 OS=Homo sapiens GN=RNF216 PE=1 SV=3 PF03119//PF10044//PF02807 NAD-dependent DNA ligase C4 zinc finger domain//Retinal tissue protein//ATP:guanido phosphotransferase, N-terminal domain GO:0006281//GO:0006351//GO:0007049//GO:0006260 DNA repair//transcription, DNA-templated//cell cycle//DNA replication GO:0003911//GO:0016301//GO:0016772 DNA ligase (NAD+) activity//kinase activity//transferase activity, transferring phosphorus-containing groups GO:0070176 DRM complex -- -- Cluster-8309.23443 BF_2 58.00 3.55 971 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23444 BF_2 106.00 3.58 1526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23446 BF_2 107.08 2.61 2001 91085771 XP_974257.1 513 4.2e-49 PREDICTED: cyclic AMP-dependent transcription factor ATF-7 [Tribolium castaneum]>gi|270010124|gb|EFA06572.1| hypothetical protein TcasGA2_TC009483 [Tribolium castaneum] -- -- -- -- -- K04450 ATF2, CREBP1 cyclic AMP-dependent transcription factor ATF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04450 P16951 242 4.6e-19 Cyclic AMP-dependent transcription factor ATF-2 OS=Mus musculus GN=Atf2 PE=1 SV=2 PF00096//PF07716//PF00170 Zinc finger, C2H2 type//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0046872//GO:0003700 sequence-specific DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.23448 BF_2 250.22 4.02 2891 270003696 EFA00144.1 2102 3.4e-233 hypothetical protein TcasGA2_TC002965 [Tribolium castaneum] 746862194 XM_011063702.1 155 8.96717e-73 PREDICTED: Acromyrmex echinatior uncharacterized LOC105150543 (LOC105150543), mRNA K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q8VHQ2 432 6.2e-41 Suppressor of cytokine signaling 7 OS=Mus musculus GN=Socs7 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.23449 BF_2 277.49 17.92 935 332373446 AEE61864.1 813 3.2e-84 unknown [Dendroctonus ponderosae]>gi|478251984|gb|ENN72420.1| hypothetical protein YQE_10938, partial [Dendroctonus ponderosae]>gi|546677825|gb|ERL88582.1| hypothetical protein D910_05967 [Dendroctonus ponderosae] 571553273 XM_001119998.3 173 2.79191e-83 PREDICTED: Apis mellifera probable N-acetyltransferase san-like (LOC724486), mRNA -- -- -- -- Q9NHD5 717 1.8e-74 Probable N-acetyltransferase san OS=Drosophila melanogaster GN=san PE=1 SV=1 PF00583//PF13508//PF08445//PF13302//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.23453 BF_2 539.61 5.22 4610 642912808 XP_008201260.1 1904 5.0e-210 PREDICTED: neurogenic protein mastermind-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21519 206 1.6e-14 Neurogenic protein mastermind OS=Drosophila melanogaster GN=mam PE=2 SV=2 PF09596 MamL-1 domain GO:0007219//GO:0045944 Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter GO:0003713 transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex -- -- Cluster-8309.23454 BF_2 198.00 3.59 2594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23455 BF_2 25.00 0.45 2611 270004760 EFA01208.1 211 5.8e-14 hypothetical protein TcasGA2_TC010535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23456 BF_2 144.19 4.36 1669 478261323 ENN80739.1 1196 2.2e-128 hypothetical protein YQE_02847, partial [Dendroctonus ponderosae]>gi|546680358|gb|ERL90637.1| hypothetical protein D910_07984 [Dendroctonus ponderosae] -- -- -- -- -- K19373 DNAJC28 DnaJ homolog subfamily C member 28 http://www.genome.jp/dbget-bin/www_bget?ko:K19373 Q9NX36 571 2.7e-57 DnaJ homolog subfamily C member 28 OS=Homo sapiens GN=DNAJC28 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0568 Molecular chaperone (DnaJ superfamily) Cluster-8309.23457 BF_2 201.98 5.25 1898 478261323 ENN80739.1 1196 2.6e-128 hypothetical protein YQE_02847, partial [Dendroctonus ponderosae]>gi|546680358|gb|ERL90637.1| hypothetical protein D910_07984 [Dendroctonus ponderosae] -- -- -- -- -- K19373 DNAJC28 DnaJ homolog subfamily C member 28 http://www.genome.jp/dbget-bin/www_bget?ko:K19373 Q9NX36 571 3.1e-57 DnaJ homolog subfamily C member 28 OS=Homo sapiens GN=DNAJC28 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0568 Molecular chaperone (DnaJ superfamily) Cluster-8309.23458 BF_2 41.00 2.52 968 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23462 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23463 BF_2 394.05 8.40 2250 478262859 ENN81341.1 1820 1.3e-200 hypothetical protein YQE_02252, partial [Dendroctonus ponderosae] 213513283 NM_001141934.1 389 0 Tribolium castaneum estrogen-related receptor (Err), mRNA K08703 NR3BN, ERR estrogen-related receptor ERR http://www.genome.jp/dbget-bin/www_bget?ko:K08703 O95718 803 4.6e-84 Steroid hormone receptor ERR2 OS=Homo sapiens GN=ESRRB PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.23464 BF_2 246.00 4.28 2692 189236918 XP_969975.2 1307 4.9e-141 PREDICTED: pantothenate kinase 4 [Tribolium castaneum]>gi|270007346|gb|EFA03794.1| hypothetical protein TcasGA2_TC013906 [Tribolium castaneum] -- -- -- -- -- K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q4R4U1 765 1.4e-79 Pantothenate kinase 4 OS=Macaca fascicularis GN=PANK4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4584 Uncharacterized conserved protein Cluster-8309.23465 BF_2 160.93 6.35 1348 642927818 XP_008195414.1 1317 1.7e-142 PREDICTED: zinc finger FYVE domain-containing protein 19 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96K21 242 3.1e-19 Abscission/NoCut checkpoint regulator OS=Homo sapiens GN=ZFYVE19 PE=1 SV=3 PF00643//PF01363 B-box zinc finger//FYVE zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.23468 BF_2 110.44 3.57 1581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23470 BF_2 308.00 10.28 1540 780632583 XP_011685835.1 629 1.2e-62 PREDICTED: regucalcin-like isoform X1 [Wasmannia auropunctata] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6DF62 396 5.0e-37 Regucalcin OS=Xenopus tropicalis GN=rgn PE=2 SV=1 PF01731 Arylesterase -- -- GO:0004064 arylesterase activity -- -- -- -- Cluster-8309.23471 BF_2 236.24 5.93 1955 642938910 XP_008195559.1 1440 1.3e-156 PREDICTED: DENN domain-containing protein 1B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 410 1.5e-38 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.23472 BF_2 405.62 3.78 4776 91094007 XP_971310.1 2349 1.3e-261 PREDICTED: DENN domain-containing protein 1A isoform X1 [Tribolium castaneum]>gi|270016162|gb|EFA12610.1| hypothetical protein TcasGA2_TC006851 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 948 1.5e-100 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.23475 BF_2 1.00 0.32 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23482 BF_2 91.58 7.20 819 642931995 XP_008196812.1 851 1.1e-88 PREDICTED: splicing factor U2AF 50 kDa subunit [Tribolium castaneum]>gi|270011684|gb|EFA08132.1| hypothetical protein TcasGA2_TC005736 [Tribolium castaneum] 642931994 XM_008198590.1 264 6.30123e-134 PREDICTED: Tribolium castaneum splicing factor U2AF 50 kDa subunit (LOC663317), mRNA K12837 U2AF2 splicing factor U2AF 65 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12837 Q24562 724 2.4e-75 Splicing factor U2AF 50 kDa subunit OS=Drosophila melanogaster GN=U2af50 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006397 mRNA processing GO:0000166//GO:0003723//GO:0003676 nucleotide binding//RNA binding//nucleic acid binding GO:0005634 nucleus KOG0120 Splicing factor U2AF, large subunit (RRM superfamily) Cluster-8309.23483 BF_2 10.98 0.54 1133 91089925 XP_972979.1 1311 7.0e-142 PREDICTED: target of rapamycin complex subunit lst8 [Tribolium castaneum] -- -- -- -- -- K08266 GBL G protein beta subunit-like http://www.genome.jp/dbget-bin/www_bget?ko:K08266 Q803V5 1066 7.4e-115 Target of rapamycin complex subunit lst8 OS=Danio rerio GN=mlst8 PE=2 SV=1 PF00400//PF02897 WD domain, G-beta repeat//Prolyl oligopeptidase, N-terminal beta-propeller domain -- -- GO:0070008//GO:0004252//GO:0005515 serine-type exopeptidase activity//serine-type endopeptidase activity//protein binding -- -- KOG0315 G-protein beta subunit-like protein (contains WD40 repeats) Cluster-8309.23484 BF_2 99.00 6.64 911 189239493 XP_975507.2 473 8.4e-45 PREDICTED: ribosomal RNA processing protein 36 homolog [Tribolium castaneum]>gi|270009556|gb|EFA06004.1| hypothetical protein TcasGA2_TC008830 [Tribolium castaneum] -- -- -- -- -- K14795 RRP36 ribosomal RNA-processing protein 36 http://www.genome.jp/dbget-bin/www_bget?ko:K14795 A7SL20 256 5.0e-21 Ribosomal RNA processing protein 36 homolog OS=Nematostella vectensis GN=v1g245966 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3190 Uncharacterized conserved protein Cluster-8309.23486 BF_2 123.00 3.16 1916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01741 Large-conductance mechanosensitive channel, MscL GO:0006810//GO:0006811 transport//ion transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.23488 BF_2 35.56 0.65 2580 189240742 XP_001808055.1 404 2.4e-36 PREDICTED: acylphosphatase-2-like isoform X3 [Tribolium castaneum]>gi|642934133|ref|XP_008199290.1| PREDICTED: acylphosphatase-2-like isoform X3 [Tribolium castaneum]>gi|270012910|gb|EFA09358.1| hypothetical protein TcasGA2_TC001919 [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P24540 230 1.5e-17 Acylphosphatase-1 OS=Sus scrofa GN=ACYP1 PE=1 SV=2 PF08718 Glycolipid transfer protein (GLTP) GO:0006094//GO:0046836//GO:0018874//GO:0006096 gluconeogenesis//glycolipid transport//benzoate metabolic process//glycolytic process GO:0003998//GO:0051861//GO:0017089 acylphosphatase activity//glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG3221 Glycolipid transfer protein Cluster-8309.23489 BF_2 16.28 0.39 2049 189240742 XP_001808055.1 404 1.9e-36 PREDICTED: acylphosphatase-2-like isoform X3 [Tribolium castaneum]>gi|642934133|ref|XP_008199290.1| PREDICTED: acylphosphatase-2-like isoform X3 [Tribolium castaneum]>gi|270012910|gb|EFA09358.1| hypothetical protein TcasGA2_TC001919 [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P24540 230 1.2e-17 Acylphosphatase-1 OS=Sus scrofa GN=ACYP1 PE=1 SV=2 PF08718 Glycolipid transfer protein (GLTP) GO:0018874//GO:0006096//GO:0046836//GO:0006094 benzoate metabolic process//glycolytic process//glycolipid transport//gluconeogenesis GO:0017089//GO:0051861//GO:0003998 glycolipid transporter activity//glycolipid binding//acylphosphatase activity GO:0005737 cytoplasm -- -- Cluster-8309.2349 BF_2 20.78 0.59 1768 646711129 KDR16428.1 484 8.6e-46 Lipase 3 [Zootermopsis nevadensis] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 474 5.1e-46 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF02450//PF04083 Lecithin:cholesterol acyltransferase//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity -- -- -- -- Cluster-8309.23492 BF_2 78.22 2.13 1820 91077854 XP_972003.1 2194 4.6e-244 PREDICTED: tetratricopeptide repeat protein 7B [Tribolium castaneum]>gi|270002262|gb|EEZ98709.1| hypothetical protein TcasGA2_TC001250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86TV6 821 3.1e-86 Tetratricopeptide repeat protein 7B OS=Homo sapiens GN=TTC7B PE=1 SV=3 PF00515//PF13181//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG4162 Predicted calmodulin-binding protein Cluster-8309.23493 BF_2 35.64 0.37 4327 91077854 XP_972003.1 1652 7.7e-181 PREDICTED: tetratricopeptide repeat protein 7B [Tribolium castaneum]>gi|270002262|gb|EEZ98709.1| hypothetical protein TcasGA2_TC001250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86TV6 594 1.5e-59 Tetratricopeptide repeat protein 7B OS=Homo sapiens GN=TTC7B PE=1 SV=3 PF13414//PF00515//PF13374//PF13181//PF13371 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4162 Predicted calmodulin-binding protein Cluster-8309.23495 BF_2 464.81 10.12 2208 91077058 XP_968505.1 2308 3.4e-257 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 2.50819e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 Q0V7M0 1916 4.0e-213 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF00514//PF11698//PF01602//PF02985//PF16006//PF10508//PF01749 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region//HEAT repeat//Nucleolar and spindle-associated protein//Proteasome non-ATPase 26S subunit//Importin beta binding domain GO:0000281//GO:0000226//GO:0015991//GO:0040001//GO:0015031//GO:0006606//GO:0043248//GO:0006886//GO:0016192 mitotic cytokinesis//microtubule cytoskeleton organization//ATP hydrolysis coupled proton transport//establishment of mitotic spindle localization//protein transport//protein import into nucleus//proteasome assembly//intracellular protein transport//vesicle-mediated transport GO:0016820//GO:0005515//GO:0008565 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//protein transporter activity GO:0030117//GO:0005819//GO:0000221//GO:0005874//GO:0005634//GO:0005737 membrane coat//spindle//vacuolar proton-transporting V-type ATPase, V1 domain//microtubule//nucleus//cytoplasm KOG0166 Karyopherin (importin) alpha Cluster-8309.23498 BF_2 10.00 0.39 1358 478258598 ENN78648.1 594 1.2e-58 hypothetical protein YQE_04821, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P52302 157 2.3e-09 Protein lethal(3)malignant blood neoplasm 1 OS=Drosophila melanogaster GN=l(3)mbn PE=2 SV=2 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.23501 BF_2 63.58 1.13 2650 332030242 EGI70025.1 2730 4.7e-306 Kelch-like protein diablo [Acromyrmex echinatior] 642921871 XM_961984.3 369 0 PREDICTED: Tribolium castaneum kelch-like protein diablo (LOC655440), mRNA K10457 KLHL20, KLEIP kelch-like protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10457 Q16RL8 2335 1.2e-261 Kelch-like protein diablo OS=Aedes aegypti GN=dbo PE=3 SV=1 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.23503 BF_2 284.42 6.46 2129 189237009 XP_967077.2 2584 3.2e-289 PREDICTED: kelch-like protein diablo [Tribolium castaneum]>gi|270007324|gb|EFA03772.1| hypothetical protein TcasGA2_TC013883 [Tribolium castaneum] 642921871 XM_961984.3 459 0 PREDICTED: Tribolium castaneum kelch-like protein diablo (LOC655440), mRNA K10457 KLHL20, KLEIP kelch-like protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10457 Q16RL8 2470 2.2e-277 Kelch-like protein diablo OS=Aedes aegypti GN=dbo PE=3 SV=1 PF01344//PF00651//PF07646 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.23506 BF_2 189.00 8.09 1265 478250790 ENN71282.1 700 5.6e-71 hypothetical protein YQE_12207, partial [Dendroctonus ponderosae]>gi|546673012|gb|ERL84698.1| hypothetical protein D910_02123 [Dendroctonus ponderosae] -- -- -- -- -- K03681 RRP40, EXOSC3 exosome complex component RRP40 http://www.genome.jp/dbget-bin/www_bget?ko:K03681 Q3T0E1 368 7.2e-34 Exosome complex component RRP40 OS=Bos taurus GN=EXOSC3 PE=2 SV=1 PF15985//PF00575 KH domain//S1 RNA binding domain -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG1004 Exosomal 3'-5' exoribonuclease complex subunit Rrp40 Cluster-8309.23510 BF_2 7.44 0.41 1042 642937449 XP_008198840.1 293 7.2e-24 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23511 BF_2 14.69 0.71 1149 861635019 KMQ91440.1 924 5.3e-97 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] 752860622 XM_011254593.1 184 2.65207e-89 PREDICTED: Camponotus floridanus putative uncharacterized protein FLJ37770 (LOC105249263), mRNA -- -- -- -- Q7JQ07 297 1.1e-25 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.23512 BF_2 36.00 0.81 2152 642937472 XP_008198851.1 354 1.3e-30 PREDICTED: protein tramtrack, beta isoform-like isoform X13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23513 BF_2 318.23 2.41 5820 478253875 ENN74167.1 2111 6.2e-234 hypothetical protein YQE_09140, partial [Dendroctonus ponderosae] 642911731 XM_008202495.1 40 1.53966e-08 PREDICTED: Tribolium castaneum uncharacterized LOC660279 (LOC660279), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23515 BF_2 43.37 1.45 1541 642914631 XP_008190292.1 980 2.3e-103 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0016787//GO:0003676//GO:0046872 hydrolase activity//nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.23519 BF_2 2.00 0.84 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23523 BF_2 2.00 0.36 521 170063054 XP_001866937.1 173 2.9e-10 scavenger receptor cysteine-rich protein [Culex quinquefasciatus]>gi|167880823|gb|EDS44206.1| scavenger receptor cysteine-rich protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23524 BF_2 19.00 0.55 1737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23525 BF_2 138.85 3.35 2022 91076754 XP_973519.1 1366 5.3e-148 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63564 356 2.8e-32 Synaptic vesicle glycoprotein 2B OS=Rattus norvegicus GN=Sv2b PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.23526 BF_2 99.71 1.49 3086 642939345 XP_008197083.1 1546 1.1e-168 PREDICTED: uncharacterized protein LOC103314054 [Tribolium castaneum] -- -- -- -- -- K09453 SNAPC4 snRNA-activating protein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09453 Q5SXM2 386 1.4e-35 snRNA-activating protein complex subunit 4 OS=Homo sapiens GN=SNAPC4 PE=1 SV=1 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0016818//GO:0005524//GO:0003676 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//nucleic acid binding GO:0005634 nucleus KOG0049 Transcription factor, Myb superfamily Cluster-8309.23533 BF_2 5.00 0.54 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23538 BF_2 452.50 4.42 4572 546682287 ERL92245.1 3267 0.0e+00 hypothetical protein D910_09562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2073 5.1e-231 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF01926//PF00664//PF00437//PF03193//PF00005//PF06414//PF07840//PF00931 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter//Zeta toxin//FadR C-terminal domain//NB-ARC domain GO:0019217//GO:0055085//GO:0006810 regulation of fatty acid metabolic process//transmembrane transport//transport GO:0005524//GO:0000062//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626 ATP binding//fatty-acyl-CoA binding//ADP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.23539 BF_2 179.38 1.49 5340 546682287 ERL92245.1 3267 0.0e+00 hypothetical protein D910_09562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2073 6.0e-231 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF00005//PF03193//PF07840//PF06414//PF00437//PF00664//PF13304//PF01926 NB-ARC domain//ABC transporter//Protein of unknown function, DUF258//FadR C-terminal domain//Zeta toxin//Type II/IV secretion system protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0055085//GO:0019217//GO:0006810 transmembrane transport//regulation of fatty acid metabolic process//transport GO:0016301//GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0000062//GO:0003924//GO:0043531 kinase activity//ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//fatty-acyl-CoA binding//GTPase activity//ADP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.23540 BF_2 183.13 1.56 5188 546682287 ERL92245.1 3267 0.0e+00 hypothetical protein D910_09562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2073 5.8e-231 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF06414//PF07840//PF03193//PF00005//PF00437//PF01926//PF13304//PF00664 NB-ARC domain//Zeta toxin//FadR C-terminal domain//Protein of unknown function, DUF258//ABC transporter//Type II/IV secretion system protein//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0019217//GO:0055085//GO:0006810 regulation of fatty acid metabolic process//transmembrane transport//transport GO:0005525//GO:0016301//GO:0016887//GO:0042626//GO:0005524//GO:0000062//GO:0043531//GO:0003924 GTP binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//fatty-acyl-CoA binding//ADP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.23542 BF_2 78.89 1.61 2339 642915126 XP_008190421.1 935 5.8e-98 PREDICTED: polynucleotide 5'-hydroxyl-kinase NOL9 [Tribolium castaneum] -- -- -- -- -- K06947 GRC3, NOL9 polynucleotide 5'-hydroxyl-kinase GRC3/NOL9 http://www.genome.jp/dbget-bin/www_bget?ko:K06947 A1ZA92 411 1.4e-38 Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Drosophila melanogaster GN=CG8414 PE=2 SV=1 PF00005//PF01580 ABC transporter//FtsK/SpoIIIE family -- -- GO:0005524//GO:0000166//GO:0003677//GO:0016887 ATP binding//nucleotide binding//DNA binding//ATPase activity -- -- KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein Cluster-8309.23543 BF_2 7.00 3.02 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23545 BF_2 4.00 1.26 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23547 BF_2 55.00 3.37 970 321479310 EFX90266.1 1038 2.7e-110 hypothetical protein DAPPUDRAFT_299917 [Daphnia pulex] 262401288 FJ774826.1 537 0 Scylla paramamosain ribosomal protein L5 mRNA, partial cds K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 P15126 995 1.1e-106 60S ribosomal protein L5-B OS=Xenopus laevis GN=rpl5-b PE=2 SV=2 PF00861 Ribosomal L18p/L5e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0875 60S ribosomal protein L5 Cluster-8309.23548 BF_2 6.00 0.31 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23549 BF_2 16.50 0.45 1820 642911217 XP_008199631.1 1154 1.8e-123 PREDICTED: FCH domain only protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UQN2 644 1.0e-65 F-BAR domain only protein 2 OS=Mus musculus GN=Fcho2 PE=1 SV=1 PF02662 Methyl-viologen-reducing hydrogenase, delta subunit GO:0055114//GO:0015948 oxidation-reduction process//methanogenesis -- -- -- -- KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.23551 BF_2 82.00 3.93 1161 659099915 AID60336.1 629 8.7e-63 trypsin-2 [Nilaparvata lugens]>gi|659100019|gb|AID60340.1| trypsin-6 [Nilaparvata lugens] 564266055 XM_006271792.1 35 1.8045e-06 PREDICTED: Alligator mississippiensis cationic trypsin-3-like (LOC102568334), mRNA -- -- -- -- Q05319 481 5.2e-47 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23553 BF_2 153.54 4.16 1830 91084337 XP_972793.1 832 4.0e-86 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 3.39418e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 542 6.9e-54 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- -- -- GO:0005515 protein binding -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.23554 BF_2 5.00 0.74 571 170070943 XP_001869764.1 136 6.3e-06 ion channel nompc [Culex quinquefasciatus]>gi|167866876|gb|EDS30259.1| ion channel nompc [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23557 BF_2 415.09 3.34 5490 478251983 ENN72419.1 2437 9.3e-272 hypothetical protein YQE_10937, partial [Dendroctonus ponderosae]>gi|546677824|gb|ERL88581.1| hypothetical protein D910_05966 [Dendroctonus ponderosae] 571553273 XM_001119998.3 173 1.68896e-82 PREDICTED: Apis mellifera probable N-acetyltransferase san-like (LOC724486), mRNA K07188 LIPE, HSL hormone-sensitive lipase http://www.genome.jp/dbget-bin/www_bget?ko:K07188 Q68J42 803 1.1e-83 Hormone-sensitive lipase OS=Sus scrofa GN=LIPE PE=2 SV=1 PF06350//PF07859//PF13508//PF00583//PF13673//PF13302//PF08445 Hormone-sensitive lipase (HSL) N-terminus//alpha/beta hydrolase fold//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0016042//GO:0008203//GO:0042967//GO:0008152 lipid catabolic process//cholesterol metabolic process//acyl-carrier-protein biosynthetic process//metabolic process GO:0016747//GO:0016298//GO:0008080//GO:0016787 transferase activity, transferring acyl groups other than amino-acyl groups//lipase activity//N-acetyltransferase activity//hydrolase activity -- -- KOG3138 Predicted N-acetyltransferase Cluster-8309.23563 BF_2 286.07 2.07 6077 642936624 XP_008198511.1 3141 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.42689e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 8.3e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF01166//PF02346 TSC-22/dip/bun family//Chordopoxvirus multifunctional envelope protein A27 GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.23564 BF_2 2915.58 85.24 1718 549438539 AGX25158.1 707 1.2e-71 windbeutel-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K09586 ERP29 endoplasmic reticulum protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K09586 O44342 341 1.3e-30 Protein windbeutel OS=Drosophila melanogaster GN=wbl PE=1 SV=1 PF07749//PF07912 Endoplasmic reticulum protein ERp29, C-terminal domain//ERp29, N-terminal domain GO:0009306 protein secretion -- -- GO:0005788//GO:0005783 endoplasmic reticulum lumen//endoplasmic reticulum -- -- Cluster-8309.23565 BF_2 71.38 1.32 2546 91079766 XP_966799.1 1315 5.4e-142 PREDICTED: protein claret segregational [Tribolium castaneum]>gi|270003319|gb|EEZ99766.1| hypothetical protein TcasGA2_TC002539 [Tribolium castaneum] -- -- -- -- -- K10405 KIFC1 kinesin family member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K10405 P20480 987 2.4e-105 Protein claret segregational OS=Drosophila melanogaster GN=ncd PE=1 SV=1 PF04192//PF06156//PF06005//PF05524//PF16796//PF00225//PF09728//PF01087//PF01166//PF08653//PF02183 Utp21 specific WD40 associated putative domain//Protein of unknown function (DUF972)//Protein of unknown function (DUF904)//PEP-utilising enzyme, N-terminal//Microtubule binding//Kinesin motor domain//Myosin-like coiled-coil protein//Galactose-1-phosphate uridyl transferase, N-terminal domain//TSC-22/dip/bun family//DASH complex subunit Dam1//Homeobox associated leucine zipper GO:0006364//GO:0009401//GO:0006260//GO:0008608//GO:0007017//GO:0006355//GO:0009117//GO:0007018//GO:0000917//GO:0043093//GO:0006012 rRNA processing//phosphoenolpyruvate-dependent sugar phosphotransferase system//DNA replication//attachment of spindle microtubules to kinetochore//microtubule-based process//regulation of transcription, DNA-templated//nucleotide metabolic process//microtubule-based movement//barrier septum assembly//FtsZ-dependent cytokinesis//galactose metabolic process GO:0008108//GO:0003700//GO:0043565//GO:0005524//GO:0008017//GO:0003777//GO:0019905 UDP-glucose:hexose-1-phosphate uridylyltransferase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//ATP binding//microtubule binding//microtubule motor activity//syntaxin binding GO:0032040//GO:0005737//GO:0042729//GO:0045298//GO:0005667//GO:0005874//GO:0072686 small-subunit processome//cytoplasm//DASH complex//tubulin complex//transcription factor complex//microtubule//mitotic spindle KOG0239 Kinesin (KAR3 subfamily) Cluster-8309.23566 BF_2 27.62 0.54 2431 91079766 XP_966799.1 1315 5.2e-142 PREDICTED: protein claret segregational [Tribolium castaneum]>gi|270003319|gb|EEZ99766.1| hypothetical protein TcasGA2_TC002539 [Tribolium castaneum] -- -- -- -- -- K10405 KIFC1 kinesin family member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K10405 P20480 987 2.3e-105 Protein claret segregational OS=Drosophila melanogaster GN=ncd PE=1 SV=1 PF04192//PF04111//PF06156//PF06005//PF05524//PF16796//PF09728//PF00225//PF01087//PF01166//PF08653//PF02183 Utp21 specific WD40 associated putative domain//Autophagy protein Apg6//Protein of unknown function (DUF972)//Protein of unknown function (DUF904)//PEP-utilising enzyme, N-terminal//Microtubule binding//Myosin-like coiled-coil protein//Kinesin motor domain//Galactose-1-phosphate uridyl transferase, N-terminal domain//TSC-22/dip/bun family//DASH complex subunit Dam1//Homeobox associated leucine zipper GO:0006012//GO:0043093//GO:0000917//GO:0007018//GO:0009117//GO:0006914//GO:0006260//GO:0009401//GO:0006364//GO:0007017//GO:0006355//GO:0008608 galactose metabolic process//FtsZ-dependent cytokinesis//barrier septum assembly//microtubule-based movement//nucleotide metabolic process//autophagy//DNA replication//phosphoenolpyruvate-dependent sugar phosphotransferase system//rRNA processing//microtubule-based process//regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore GO:0003777//GO:0019905//GO:0008017//GO:0005524//GO:0043565//GO:0003700//GO:0008108 microtubule motor activity//syntaxin binding//microtubule binding//ATP binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0072686//GO:0005874//GO:0005667//GO:0045298//GO:0042729//GO:0032040//GO:0005737 mitotic spindle//microtubule//transcription factor complex//tubulin complex//DASH complex//small-subunit processome//cytoplasm KOG0239 Kinesin (KAR3 subfamily) Cluster-8309.23568 BF_2 79.62 0.70 5069 478256706 ENN76888.1 3154 0.0e+00 hypothetical protein YQE_06729, partial [Dendroctonus ponderosae]>gi|546685096|gb|ERL94623.1| hypothetical protein D910_11899 [Dendroctonus ponderosae] 642938565 XM_008201622.1 70 2.81914e-25 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X7, mRNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 4.2e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF09258 Glycosyl transferase family 64 domain GO:0006024//GO:0015012 glycosaminoglycan biosynthetic process//heparan sulfate proteoglycan biosynthetic process -- -- GO:0016021 integral component of membrane KOG1021 Acetylglucosaminyltransferase EXT1/exostosin 1 Cluster-8309.23569 BF_2 22.74 0.78 1512 270004583 EFA01031.1 541 1.8e-52 hypothetical protein TcasGA2_TC003947 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P35789 481 6.8e-47 Zinc finger protein 93 OS=Homo sapiens GN=ZNF93 PE=2 SV=4 PF01258//PF13912//PF13465//PF00096 Prokaryotic dksA/traR C4-type zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.23570 BF_2 668.31 11.63 2692 189240191 XP_001815657.1 2752 1.3e-308 PREDICTED: uncharacterized protein LOC100142139 [Tribolium castaneum] 642932121 XM_001815605.2 498 0 PREDICTED: Tribolium castaneum uncharacterized LOC100142139 (LOC100142139), mRNA -- -- -- -- Q18PE1 413 9.3e-39 Protein Dok-7 OS=Homo sapiens GN=DOK7 PE=1 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.23571 BF_2 3.01 0.33 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23572 BF_2 373.80 2.98 5542 642937261 XP_008198761.1 2847 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270001290|gb|EEZ97737.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70389 441 1.1e-41 Insulin-like growth factor-binding protein complex acid labile subunit OS=Mus musculus GN=Igfals PE=2 SV=1 PF13855//PF00560//PF01299//PF01080 Leucine rich repeat//Leucine Rich Repeat//Lysosome-associated membrane glycoprotein (Lamp)//Presenilin -- -- GO:0005515//GO:0004190 protein binding//aspartic-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.23575 BF_2 315.36 10.31 1567 642935999 XP_973446.3 1347 6.5e-146 PREDICTED: uncharacterized protein YJR142W [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47173 436 1.2e-41 Uncharacterized protein YJR142W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJR142W PE=1 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4313 Thiamine pyrophosphokinase Cluster-8309.23579 BF_2 8.00 1.81 472 114153284 ABI52808.1 701 1.6e-71 40S ribosomal protein S23 [Argas monolakensis]>gi|149287132|gb|ABR23465.1| 40S ribosomal protein S23 [Ornithodoros parkeri] 733926754 XM_010726086.1 139 1.08212e-64 PREDICTED: Meleagris gallopavo ribosomal protein S23 (RPS23), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q86FP7 699 1.1e-72 40S ribosomal protein S23 OS=Dermacentor variabilis GN=RpS23 PE=2 SV=1 PF00164 Ribosomal protein S12/S23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0015935//GO:0005622 ribosome//small ribosomal subunit//intracellular KOG1749 40S ribosomal protein S23 Cluster-8309.23580 BF_2 126.00 10.50 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23581 BF_2 39.39 1.09 1803 478257579 ENN77733.1 1395 2.0e-151 hypothetical protein YQE_05804, partial [Dendroctonus ponderosae] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 812 3.4e-85 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690//PF04851 Sugar (and other) transporter//Major Facilitator Superfamily//Type III restriction enzyme, res subunit GO:0055085 transmembrane transport GO:0016787//GO:0003677//GO:0022857//GO:0005524 hydrolase activity//DNA binding//transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.23582 BF_2 4.00 0.96 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23583 BF_2 45.47 1.56 1504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006813//GO:0006814 potassium ion transport//sodium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.23585 BF_2 221.24 4.23 2475 642921203 XP_008192760.1 1319 1.8e-142 PREDICTED: uncharacterized protein LOC103312841 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 P82798 286 4.5e-24 Transcriptional regulator ATRX (Fragment) OS=Macropus eugenii GN=ATRX PE=2 SV=1 PF00628//PF00539 PHD-finger//Transactivating regulatory protein (Tat) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700 protein binding//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.23586 BF_2 92.90 0.70 5859 820805554 AKG92768.1 605 2.7e-59 cropped [Leptinotarsa decemlineata] -- -- -- -- -- K09108 TFAP4 transcription factor AP-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09108 Q01664 164 1.5e-09 Transcription factor AP-4 OS=Homo sapiens GN=TFAP4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23589 BF_2 79.16 1.37 2701 642924494 XP_008194318.1 1947 3.0e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 6.8e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.23590 BF_2 3.00 1.91 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23591 BF_2 9.00 1.23 594 642928508 XP_008193820.1 223 5.4e-16 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23592 BF_2 555.25 8.65 2971 642928510 XP_008193821.1 3134 0.0e+00 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] 755894366 XM_011297040.1 39 2.80997e-08 PREDICTED: Musca domestica multiple C2 and transmembrane domain-containing protein 1 (LOC101898395), transcript variant X1, mRNA -- -- -- -- Q6DN14 1246 2.6e-135 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00168//PF00606 C2 domain//Herpesvirus Glycoprotein B -- -- GO:0005515 protein binding GO:0016020 membrane KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.23594 BF_2 72.68 0.95 3497 642919964 XP_008192146.1 1484 1.9e-161 PREDICTED: DNA repair protein XRCC1 isoform X1 [Tribolium castaneum]>gi|270005349|gb|EFA01797.1| hypothetical protein TcasGA2_TC007398 [Tribolium castaneum] -- -- -- -- -- K10803 XRCC1 DNA-repair protein XRCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K10803 Q8NCM8 667 4.2e-68 Cytoplasmic dynein 2 heavy chain 1 OS=Homo sapiens GN=DYNC2H1 PE=1 SV=4 PF03028//PF01834 Dynein heavy chain and region D6 of dynein motor//XRCC1 N terminal domain GO:0007017//GO:0000012//GO:0007018//GO:0006281 microtubule-based process//single strand break repair//microtubule-based movement//DNA repair GO:0003684//GO:0003777 damaged DNA binding//microtubule motor activity GO:0030286//GO:0005634//GO:0005874 dynein complex//nucleus//microtubule KOG3595 Dyneins, heavy chain Cluster-8309.23595 BF_2 47.00 1.98 1279 332372662 AEE61473.1 1010 6.4e-107 unknown [Dendroctonus ponderosae]>gi|478255518|gb|ENN75735.1| hypothetical protein YQE_07695, partial [Dendroctonus ponderosae]>gi|546675924|gb|ERL87024.1| hypothetical protein D910_04426 [Dendroctonus ponderosae] 815909538 XM_012384963.1 186 2.28666e-90 PREDICTED: Bombus impatiens cilia- and flagella-associated protein 20 (LOC105680695), mRNA -- -- -- -- Q6B857 946 6.9e-101 Cilia- and flagella-associated protein 20 OS=Bos taurus GN=CFAP20 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3213 Transcription factor IIB Cluster-8309.23596 BF_2 58.01 0.82 3245 642919745 XP_008192047.1 1663 3.1e-182 PREDICTED: transmembrane protein 131 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92545 416 5.0e-39 Transmembrane protein 131 OS=Homo sapiens GN=TMEM131 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3620 Uncharacterized conserved protein Cluster-8309.23597 BF_2 369.00 8.75 2051 642914087 XP_970230.2 1153 2.7e-123 PREDICTED: progestin and adipoQ receptor family member 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TCH7 592 1.2e-59 Progestin and adipoQ receptor family member 3 OS=Homo sapiens GN=PAQR3 PE=1 SV=2 PF01427//PF03006 D-ala-D-ala dipeptidase//Haemolysin-III related GO:0006508 proteolysis GO:0008237//GO:0016805 metallopeptidase activity//dipeptidase activity GO:0005618//GO:0016021 cell wall//integral component of membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.23598 BF_2 76.29 0.57 5935 642924788 XP_008194040.1 2706 6.4e-303 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 1512 7.5e-166 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF08926//PF08447//PF00516//PF01554//PF00989 Domain of unknown function (DUF1908)//PAS fold//Envelope glycoprotein GP120//MatE//PAS fold GO:0015893//GO:0006855//GO:0016310//GO:0006355//GO:0055085//GO:0009069//GO:0006468//GO:0006810 drug transport//drug transmembrane transport//phosphorylation//regulation of transcription, DNA-templated//transmembrane transport//serine family amino acid metabolic process//protein phosphorylation//transport GO:0000287//GO:0015297//GO:0005515//GO:0004674//GO:0005524//GO:0015238 magnesium ion binding//antiporter activity//protein binding//protein serine/threonine kinase activity//ATP binding//drug transmembrane transporter activity GO:0016020//GO:0019031 membrane//viral envelope KOG3753 Circadian clock protein period Cluster-8309.23604 BF_2 61.52 2.36 1380 91083111 XP_970182.1 1198 1.1e-128 PREDICTED: L-galactose dehydrogenase [Tribolium castaneum]>gi|270007677|gb|EFA04125.1| hypothetical protein TcasGA2_TC014368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O81884 513 1.2e-50 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1576 Predicted oxidoreductase Cluster-8309.23605 BF_2 27.90 0.74 1864 91093821 XP_969004.1 656 1.0e-65 PREDICTED: UDP-glucuronosyltransferase 2B9 [Tribolium castaneum]>gi|270015903|gb|EFA12351.1| hypothetical protein TcasGA2_TC002056 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9GLD9 322 2.3e-28 UDP-glucuronosyltransferase 2B33 OS=Macaca mulatta GN=UGT2B33 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.23609 BF_2 535.21 6.29 3849 189238033 XP_966902.2 1468 1.5e-159 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 242 5.19138e-121 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 844 1.4e-88 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF15048//PF02535//PF01757//PF00892 Organic solute transporter subunit beta protein//ZIP Zinc transporter//Acyltransferase family//EamA-like transporter family GO:0006810//GO:0015721//GO:0055085//GO:0030001 transport//bile acid and bile salt transport//transmembrane transport//metal ion transport GO:0046982//GO:0005215//GO:0016747//GO:0046873 protein heterodimerization activity//transporter activity//transferase activity, transferring acyl groups other than amino-acyl groups//metal ion transmembrane transporter activity GO:0005886//GO:0016021//GO:0016020 plasma membrane//integral component of membrane//membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.23613 BF_2 103.41 4.75 1198 332374344 AEE62313.1 1119 1.4e-119 unknown [Dendroctonus ponderosae]>gi|478253634|gb|ENN73938.1| hypothetical protein YQE_09440, partial [Dendroctonus ponderosae]>gi|546684541|gb|ERL94169.1| hypothetical protein D910_11451 [Dendroctonus ponderosae] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q3B7M2 897 3.1e-95 Hydroxyacylglutathione hydrolase, mitochondrial OS=Bos taurus GN=HAGH PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0813 Glyoxylase Cluster-8309.23618 BF_2 61.86 0.57 4826 91092828 XP_968011.1 2813 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 4 [Tribolium castaneum]>gi|270004790|gb|EFA01238.1| gluon [Tribolium castaneum] -- -- -- -- -- K06675 SMC4 structural maintenance of chromosome 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06675 P50532 1880 1.3e-208 Structural maintenance of chromosomes protein 4 OS=Xenopus laevis GN=smc4 PE=1 SV=1 PF06470//PF00005//PF13304//PF06160 SMC proteins Flexible Hinge Domain//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//Septation ring formation regulator, EzrA GO:0000921//GO:0051276//GO:0006259 septin ring assembly//chromosome organization//DNA metabolic process GO:0005515//GO:0005524//GO:0016887 protein binding//ATP binding//ATPase activity GO:0005940//GO:0016021//GO:0005694 septin ring//integral component of membrane//chromosome KOG0996 Structural maintenance of chromosome protein 4 (chromosome condensation complex Condensin, subunit C) Cluster-8309.23619 BF_2 155.90 22.27 580 478255411 ENN75633.1 568 5.2e-56 hypothetical protein YQE_07811, partial [Dendroctonus ponderosae] -- -- -- -- -- K02899 RP-L27, MRPL27, rpmA large subunit ribosomal protein L27 http://www.genome.jp/dbget-bin/www_bget?ko:K02899 Q99N92 235 8.7e-19 39S ribosomal protein L27, mitochondrial OS=Mus musculus GN=Mrpl27 PE=2 SV=1 PF01016 Ribosomal L27 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG4600 Mitochondrial ribosomal protein MRP7 (L2) Cluster-8309.23620 BF_2 6.00 0.35 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23621 BF_2 9.00 0.44 1147 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23623 BF_2 3.76 0.34 752 91080023 XP_972063.1 415 3.7e-38 PREDICTED: beta-1,3-glucan-binding protein isoform X1 [Tribolium castaneum]>gi|270004908|gb|EFA01356.1| Gram-negative bacteria binding protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NHA8 404 2.9e-38 Gram-negative bacteria-binding protein 3 OS=Drosophila melanogaster GN=GNBP3 PE=1 SV=2 PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.23624 BF_2 103.99 0.71 6404 478254712 ENN74953.1 1284 5.4e-138 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 1247 4.3e-135 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF00722//PF15886 Glycosyl hydrolases family 16//Carbohydrate binding domain (family 32) GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.23626 BF_2 241.59 1.70 6237 642932464 XP_008197125.1 6560 0.0e+00 PREDICTED: WD repeat-containing protein 81 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17601 WDR81 WD repeat-containing protein 81 http://www.genome.jp/dbget-bin/www_bget?ko:K17601 D4A929 968 9.5e-103 WD repeat-containing protein 81 OS=Rattus norvegicus GN=Wdr81 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.23627 BF_2 18.00 0.38 2279 7320913 CAA72032.2 1280 5.6e-138 masquerade-like protein [Pacifastacus leniusculus] 301030826 GU373915.1 560 0 Portunus trituberculatus masquerade-like protein mRNA, partial cds -- -- -- -- P26262 406 5.1e-38 Plasma kallikrein OS=Mus musculus GN=Klkb1 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23629 BF_2 18.11 0.32 2685 546681143 ERL91293.1 277 1.3e-21 hypothetical protein D910_08626 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08603 Adenylate cyclase associated (CAP) C terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.23630 BF_2 6.00 3.67 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.23631 BF_2 7.00 0.37 1079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23632 BF_2 43.00 8.45 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23633 BF_2 5.00 0.61 631 642917050 XP_008191099.1 249 5.5e-19 PREDICTED: ras-related GTP-binding protein C isoform X1 [Tribolium castaneum] -- -- -- -- -- K16186 RRAGC_D Ras-related GTP-binding protein C/D http://www.genome.jp/dbget-bin/www_bget?ko:K16186 Q9HB90 167 7.2e-11 Ras-related GTP-binding protein C OS=Homo sapiens GN=RRAGC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3887 Predicted small GTPase involved in nuclear protein import Cluster-8309.23634 BF_2 7.00 0.42 982 443724007 ELU12214.1 200 4.1e-13 hypothetical protein CAPTEDRAFT_213751 [Capitella teleta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23635 BF_2 503.89 5.63 4028 642932100 XP_008196854.1 1731 5.0e-190 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 642932099 XM_008198632.1 463 0 PREDICTED: Tribolium castaneum SPRY domain-containing SOCS box protein 1 (LOC664070), transcript variant X2, mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 5.1e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF00622//PF07525//PF01213 SPRY domain//SOCS box//Adenylate cyclase associated (CAP) N terminal GO:0035556//GO:0007010 intracellular signal transduction//cytoskeleton organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.23637 BF_2 107.44 1.36 3595 642934083 XP_008196496.1 1036 1.7e-109 PREDICTED: phosphatase and actin regulator 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.6e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0015031//GO:0016192 protein transport//vesicle-mediated transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4339 RPEL repeat-containing protein Cluster-8309.23639 BF_2 52.24 0.71 3372 642922112 XP_008193020.1 613 1.8e-60 PREDICTED: calcium channel flower isoform X2 [Tribolium castaneum]>gi|270007428|gb|EFA03876.1| hypothetical protein TcasGA2_TC014000 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 324 2.4e-28 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF03613//PF10233 PTS system mannose/fructose/sorbose family IID component//Uncharacterized conserved protein CG6151-P GO:0009401//GO:0006816//GO:0070588//GO:0048488 phosphoenolpyruvate-dependent sugar phosphotransferase system//calcium ion transport//calcium ion transmembrane transport//synaptic vesicle endocytosis GO:0005262 calcium channel activity GO:0016021//GO:0030285 integral component of membrane//integral component of synaptic vesicle membrane KOG4085 Uncharacterized conserved protein Cluster-8309.23643 BF_2 2.00 0.62 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23646 BF_2 18.15 0.42 2079 642913624 XP_008201093.1 1643 4.1e-180 PREDICTED: dopamine receptor 2 isoform X1 [Tribolium castaneum] 751447362 XM_011179515.1 81 8.79103e-32 PREDICTED: Bactrocera cucurbitae dopamine receptor 2 (LOC105209216), mRNA K04137 ADRA1D adrenergic receptor alpha-1D http://www.genome.jp/dbget-bin/www_bget?ko:K04137 Q24563 1304 3.4e-142 Dopamine receptor 2 OS=Drosophila melanogaster GN=Dop1R2 PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.23647 BF_2 3.00 0.53 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23651 BF_2 230.00 1.76 5744 91080461 XP_969971.1 2463 9.4e-275 PREDICTED: menin [Tribolium castaneum]>gi|270005763|gb|EFA02211.1| hypothetical protein TcasGA2_TC007870 [Tribolium castaneum] 642919233 XM_964878.2 122 3.96399e-54 PREDICTED: Tribolium castaneum menin (LOC658495), mRNA K14970 MEN1, MNN1 menin http://www.genome.jp/dbget-bin/www_bget?ko:K14970 O88559 1191 1.2e-128 Menin OS=Mus musculus GN=Men1 PE=1 SV=2 PF05053 Menin -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.23652 BF_2 406.59 4.64 3956 478255072 ENN75302.1 3267 0.0e+00 hypothetical protein YQE_08079, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 8.3e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.23653 BF_2 5.19 0.81 556 642910859 XP_008193438.1 517 4.1e-50 PREDICTED: mitogen-activated protein kinase 14B-like [Tribolium castaneum] 733868735 XM_003201950.2 94 1.33262e-39 PREDICTED: Meleagris gallopavo mitogen-activated protein kinase 11 (MAPK11), mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 485 8.6e-48 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0660 Mitogen-activated protein kinase Cluster-8309.23655 BF_2 16.70 0.57 1520 817076849 XP_012260720.1 342 2.2e-29 PREDICTED: beclin 1-associated autophagy-related key regulator isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10186//PF00643 Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0010508 positive regulation of autophagy GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.23657 BF_2 38.77 0.58 3085 91086917 XP_971585.1 888 2.1e-92 PREDICTED: DNA polymerase iota [Tribolium castaneum]>gi|270009670|gb|EFA06118.1| hypothetical protein TcasGA2_TC008961 [Tribolium castaneum] -- -- -- -- -- K03510 POLI DNA polymerase iota http://www.genome.jp/dbget-bin/www_bget?ko:K03510 Q6R3M4 585 1.2e-58 DNA polymerase iota OS=Mus musculus GN=Poli PE=1 SV=1 PF02245//PF11799//PF00817//PF06390 Methylpurine-DNA glycosylase (MPG)//impB/mucB/samB family C-terminal domain//impB/mucB/samB family//Neuroendocrine-specific golgi protein P55 (NESP55) GO:0006260//GO:0006281//GO:0071107//GO:0006284 DNA replication//DNA repair//response to parathyroid hormone//base-excision repair GO:0003684//GO:0003887//GO:0003905//GO:0003677 damaged DNA binding//DNA-directed DNA polymerase activity//alkylbase DNA N-glycosylase activity//DNA binding GO:0042575 DNA polymerase complex KOG2095 DNA polymerase iota/DNA damage inducible protein Cluster-8309.23658 BF_2 81.23 1.19 3140 91086917 XP_971585.1 1557 5.8e-170 PREDICTED: DNA polymerase iota [Tribolium castaneum]>gi|270009670|gb|EFA06118.1| hypothetical protein TcasGA2_TC008961 [Tribolium castaneum] -- -- -- -- -- K03510 POLI DNA polymerase iota http://www.genome.jp/dbget-bin/www_bget?ko:K03510 Q9UNA4 786 6.1e-82 DNA polymerase iota OS=Homo sapiens GN=POLI PE=1 SV=3 PF02245//PF06390//PF00817//PF11799 Methylpurine-DNA glycosylase (MPG)//Neuroendocrine-specific golgi protein P55 (NESP55)//impB/mucB/samB family//impB/mucB/samB family C-terminal domain GO:0006281//GO:0071107//GO:0006284 DNA repair//response to parathyroid hormone//base-excision repair GO:0003684//GO:0003905//GO:0003677 damaged DNA binding//alkylbase DNA N-glycosylase activity//DNA binding -- -- KOG2095 DNA polymerase iota/DNA damage inducible protein Cluster-8309.23659 BF_2 16.44 0.50 1668 332374492 AEE62387.1 813 5.8e-84 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05109 333 1.1e-29 Venom allergen 5 (Fragment) OS=Polistes annularis PE=1 SV=1 PF07782 DC-STAMP-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.23660 BF_2 592.89 19.38 1567 332374492 AEE62387.1 845 1.1e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05109 333 1.0e-29 Venom allergen 5 (Fragment) OS=Polistes annularis PE=1 SV=1 PF07782 DC-STAMP-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.23663 BF_2 260.74 2.85 4119 642933430 XP_008197415.1 3324 0.0e+00 PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 630 9.8e-64 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG4485 Uncharacterized conserved protein, contains ankyrin and FN3 repeats Cluster-8309.23666 BF_2 147.65 3.85 1893 642933420 XP_008197410.1 1668 4.7e-183 PREDICTED: ankyrin repeat and fibronectin type-III domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N957 355 3.5e-32 Ankyrin repeat and fibronectin type-III domain-containing protein 1 OS=Homo sapiens GN=ANKFN1 PE=2 SV=2 PF13606//PF12678 Ankyrin repeat//RING-H2 zinc finger -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.23667 BF_2 55.00 1.34 1998 642927673 XP_008195359.1 2978 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase 1 [Tribolium castaneum] 795069100 XM_012019555.1 194 1.28862e-94 PREDICTED: Vollenhovia emeryi diacylglycerol kinase 1 (LOC105565940), transcript variant X3, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q9Y6T7 1942 3.5e-216 Diacylglycerol kinase beta OS=Homo sapiens GN=DGKB PE=2 SV=2 PF00628//PF07649//PF07163//PF00130//PF00609//PF00036//PF13202//PF00781 PHD-finger//C1-like domain//Pex26 protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//EF hand//EF hand//Diacylglycerol kinase catalytic domain GO:0035556//GO:0055114//GO:0046486//GO:0007205//GO:0009395//GO:0045046 intracellular signal transduction//oxidation-reduction process//glycerolipid metabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//protein import into peroxisome membrane GO:0005509//GO:0016301//GO:0047134//GO:0004143//GO:0032403//GO:0005515 calcium ion binding//kinase activity//protein-disulfide reductase activity//diacylglycerol kinase activity//protein complex binding//protein binding GO:0005779 integral component of peroxisomal membrane KOG1169 Diacylglycerol kinase Cluster-8309.23672 BF_2 145.00 2.95 2343 546679056 ERL89579.1 1185 5.9e-127 hypothetical protein D910_06944 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N6Q8 485 3.6e-47 Methyltransferase-like protein 25 OS=Homo sapiens GN=METTL25 PE=2 SV=2 PF05206 Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.23674 BF_2 165.00 20.37 626 91091946 XP_967800.1 569 4.3e-56 PREDICTED: 39S ribosomal protein L30, mitochondrial [Tribolium castaneum]>gi|270001145|gb|EEZ97592.1| hypothetical protein TcasGA2_TC011456 [Tribolium castaneum] -- -- -- -- -- K02907 RP-L30, MRPL30, rpmD large subunit ribosomal protein L30 http://www.genome.jp/dbget-bin/www_bget?ko:K02907 Q4R6U7 185 5.9e-13 39S ribosomal protein L30, mitochondrial OS=Macaca fascicularis GN=MRPL30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4799 Mitochondrial ribosomal protein L30 Cluster-8309.23677 BF_2 430.28 1.93 9623 270005280 EFA01728.1 8299 0.0e+00 hypothetical protein TcasGA2_TC007308 [Tribolium castaneum] 642920256 XM_008194048.1 93 8.79348e-38 PREDICTED: Tribolium castaneum pecanex-like protein 1 (LOC664487), transcript variant X2, mRNA -- -- -- -- Q96RV3 3295 0.0e+00 Pecanex-like protein 1 OS=Homo sapiens GN=PCNX PE=1 SV=2 PF05041//PF11095//PF06753 Pecanex protein (C-terminus)//Gem-associated protein 7 (Gemin7)//Bradykinin GO:0007165//GO:0006950 signal transduction//response to stress GO:0005179 hormone activity GO:0032797//GO:0016021//GO:0005576 SMN complex//integral component of membrane//extracellular region KOG3604 Pecanex Cluster-8309.23678 BF_2 266.00 3.42 3545 642930595 XP_001807608.2 1655 2.8e-181 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05805//PF14850//PF05777//PF00240//PF14560 L6 membrane protein//DNA-binding domain of Proline dehydrogenase//Drosophila accessory gland-specific peptide 26Ab (Acp26Ab)//Ubiquitin family//Ubiquitin-like domain GO:0055114//GO:0007617//GO:0006525//GO:0006561 oxidation-reduction process//mating behavior//arginine metabolic process//proline biosynthetic process GO:0003842//GO:0005515 1-pyrroline-5-carboxylate dehydrogenase activity//protein binding GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.23679 BF_2 91.93 2.08 2140 571533289 XP_006561360.1 595 1.4e-58 PREDICTED: uncharacterized protein LOC725964 isoform X1 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88281 393 1.5e-36 Multiple epidermal growth factor-like domains protein 6 OS=Rattus norvegicus GN=Megf6 PE=1 SV=1 PF07645 Calcium-binding EGF domain -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.23681 BF_2 49.00 1.73 1470 642935669 XP_008198107.1 344 1.2e-29 PREDICTED: uncharacterized protein LOC103314279 [Tribolium castaneum]>gi|270013301|gb|EFA09749.1| hypothetical protein TcasGA2_TC011888 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23682 BF_2 5.00 2.58 365 270005445 EFA01893.1 206 3.1e-14 hypothetical protein TcasGA2_TC007503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23683 BF_2 93.36 1.48 2918 91087879 XP_969925.1 546 9.2e-53 PREDICTED: paired mesoderm homeobox protein 2 [Tribolium castaneum]>gi|270012765|gb|EFA09213.1| munster [Tribolium castaneum] 154146242 NM_001100174.1 103 7.30103e-44 Rattus norvegicus aristaless related homeobox (Arx), mRNA >gnl|BL_ORD_ID|4283590 Rattus norvegicus aristaless-related homeobox protein mRNA, complete cds K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 A6YP92 326 1.2e-28 Homeobox protein ARX OS=Rattus norvegicus GN=Arx PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.23684 BF_2 21.64 0.46 2275 826409428 XP_012532627.1 185 5.2e-11 PREDICTED: fatty acid synthase-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01098 Cell cycle protein GO:0051301 cell division -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.23687 BF_2 471.36 3.32 6235 642940402 XP_008200549.1 6889 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 752868301 XM_011252918.1 50 4.55564e-14 PREDICTED: Camponotus floridanus Down syndrome cell adhesion molecule-like protein Dscam2 (LOC105248250), mRNA -- -- -- -- Q9VS29 2959 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF03824//PF05790//PF13895//PF00041 High-affinity nickel-transport protein//Immunoglobulin C2-set domain//Immunoglobulin domain//Fibronectin type III domain GO:0007155//GO:0035444//GO:0015675 cell adhesion//nickel cation transmembrane transport//nickel cation transport GO:0015099//GO:0005515//GO:0046872 nickel cation transmembrane transporter activity//protein binding//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.23688 BF_2 10.00 0.49 1137 662212467 XP_008479970.1 181 7.6e-11 PREDICTED: zinc finger protein 425-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 140 1.8e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF16622//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.23689 BF_2 19.06 0.36 2529 642931425 XP_008196577.1 1339 8.9e-145 PREDICTED: tRNA (uracil-5-)-methyltransferase homolog A [Tribolium castaneum] -- -- -- -- -- K15332 TRMT2A tRNA (uracil-5-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15332 Q8IZ69 847 4.1e-89 tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 PF05958//PF09445//PF02384//PF05175//PF01135//PF02390//PF08241//PF00076//PF01209//PF05401//PF03602 tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//N-6 DNA Methylase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Putative methyltransferase//Methyltransferase domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ubiE/COQ5 methyltransferase family//Nodulation protein S (NodS)//Conserved hypothetical protein 95 GO:0008033//GO:0006396//GO:0009312//GO:0006464//GO:0031167//GO:0009451//GO:0006479//GO:0009877//GO:0046500//GO:0006306//GO:0006400//GO:0001510//GO:0008152//GO:0009452 tRNA processing//RNA processing//oligosaccharide biosynthetic process//cellular protein modification process//rRNA methylation//RNA modification//protein methylation//nodulation//S-adenosylmethionine metabolic process//DNA methylation//tRNA modification//RNA methylation//metabolic process//7-methylguanosine RNA capping GO:0008170//GO:0008168//GO:0008176//GO:0004719//GO:0003676//GO:0003677//GO:0008757//GO:0008173 N-methyltransferase activity//methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nucleic acid binding//DNA binding//S-adenosylmethionine-dependent methyltransferase activity//RNA methyltransferase activity -- -- KOG2187 tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes Cluster-8309.23694 BF_2 4.20 0.33 814 546686052 ERL95452.1 317 9.2e-27 hypothetical protein D910_12714 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q01842 131 1.4e-06 Ets DNA-binding protein pokkuri OS=Drosophila melanogaster GN=aop PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.23696 BF_2 378.65 2.53 6560 642918326 XP_008199092.1 2616 1.9e-292 PREDICTED: protein Shroom [Tribolium castaneum] -- -- -- -- -- K18625 SHROOM protein Shroom http://www.genome.jp/dbget-bin/www_bget?ko:K18625 Q09JY9 372 1.3e-33 Protein Shroom2 OS=Xenopus tropicalis GN=shroom2 PE=2 SV=1 PF07353 Uroplakin II GO:0061024 membrane organization -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.23697 BF_2 432.28 3.58 5344 91093220 XP_967110.1 1998 7.2e-221 PREDICTED: putative Golgi pH regulator C [Tribolium castaneum]>gi|270016591|gb|EFA13037.1| hypothetical protein TcasGA2_TC010568 [Tribolium castaneum] 170065886 XM_001868022.1 246 4.31876e-123 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA -- -- -- -- B5X1G3 1455 2.7e-159 Golgi pH regulator OS=Salmo salar GN=gpr89 PE=2 SV=1 PF06293//PF00069//PF12537//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//The Golgi pH Regulator (GPHR) Family N-terminal//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG2417 Predicted G-protein coupled receptor Cluster-8309.23698 BF_2 193.00 4.12 2245 189240491 XP_001810703.1 929 2.8e-97 PREDICTED: uncharacterized protein LOC100142309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.23699 BF_2 21.00 0.41 2453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23700 BF_2 98.87 1.08 4122 270001539 EEZ97986.1 1833 7.6e-202 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 8.92211e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 5.8e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.23703 BF_2 1.00 3.52 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23712 BF_2 6.00 0.37 959 645008379 XP_003425747.2 159 2.3e-08 PREDICTED: uncharacterized protein LOC100680211 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01025 GrpE GO:0006457 protein folding GO:0000774//GO:0051087//GO:0042803 adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity -- -- -- -- Cluster-8309.23713 BF_2 51.36 0.50 4612 642923482 XP_008193528.1 1562 2.3e-170 PREDICTED: hyccin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BYI3 417 5.5e-39 Hyccin OS=Homo sapiens GN=FAM126A PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.23714 BF_2 41.73 2.86 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23717 BF_2 422.54 1.78 10208 -- -- -- -- -- 642912856 XM_008203060.1 43 5.81746e-10 PREDICTED: Tribolium castaneum AP-1 complex subunit sigma-2 (LOC659702), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23718 BF_2 28.52 1.03 1442 332373248 AEE61765.1 735 5.5e-75 unknown [Dendroctonus ponderosae]>gi|478262478|gb|ENN81149.1| hypothetical protein YQE_02515, partial [Dendroctonus ponderosae]>gi|546672789|gb|ERL84545.1| hypothetical protein D910_01975 [Dendroctonus ponderosae] 242011937 XM_002426655.1 180 5.5983e-87 Pediculus humanus corporis clathrin coat assembly protein ap19, putative, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 Q9DB50 659 1.5e-67 AP-1 complex subunit sigma-2 OS=Mus musculus GN=Ap1s2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.23719 BF_2 21.00 1.81 772 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.23721 BF_2 231.27 5.46 2058 270006394 EFA02842.1 849 4.8e-88 hypothetical protein TcasGA2_TC007619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00214 353 6.4e-32 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.23722 BF_2 63.78 5.28 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.23725 BF_2 129.00 4.55 1474 296023724 ADG83846.1 1858 3.4e-205 serine proteinase-like protein [Scylla paramamosain] 296023723 GU250783.1 1262 0 Scylla paramamosain serine proteinase-like protein mRNA, complete cds -- -- -- -- Q05319 367 1.1e-33 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.23727 BF_2 238.45 1.57 6633 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF14249//PF00028 Tocopherol cyclase//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0009976//GO:0005509 tocopherol cyclase activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.23728 BF_2 372.00 62.02 538 642931814 XP_008196744.1 589 1.8e-58 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 482 1.8e-47 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.23731 BF_2 546.62 15.79 1735 642924825 XP_967668.2 801 1.5e-82 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03336 364 2.9e-33 Regucalcin OS=Rattus norvegicus GN=Rgn PE=1 SV=3 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23736 BF_2 828.45 31.42 1390 91091102 XP_968698.1 1218 5.3e-131 PREDICTED: PDZ domain-containing protein GIPC3 [Tribolium castaneum]>gi|270013145|gb|EFA09593.1| hypothetical protein TcasGA2_TC011711 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14908 775 5.1e-81 PDZ domain-containing protein GIPC1 OS=Homo sapiens GN=GIPC1 PE=1 SV=2 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3938 RGS-GAIP interacting protein GIPC, contains PDZ domain Cluster-8309.23739 BF_2 157.20 0.91 7545 642929737 XP_008195956.1 3594 0.0e+00 PREDICTED: zinc finger SWIM domain-containing protein 6-like isoform X3 [Tribolium castaneum] 642929732 XM_008197732.1 1138 0 PREDICTED: Tribolium castaneum zinc finger SWIM domain-containing protein 6-like (LOC664434), transcript variant X1, mRNA -- -- -- -- Q9P217 2085 3.4e-232 Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 PF04434//PF02861//PF05063//PF01189 SWIM zinc finger//Clp amino terminal domain, pathogenicity island component//MT-A70//16S rRNA methyltransferase RsmF GO:0006139//GO:0019538 nucleobase-containing compound metabolic process//protein metabolic process GO:0008168//GO:0008270 methyltransferase activity//zinc ion binding -- -- KOG3615 Uncharacterized conserved protein Cluster-8309.23741 BF_2 16.16 0.75 1192 478250650 ENN71142.1 634 2.4e-63 hypothetical protein YQE_12073, partial [Dendroctonus ponderosae] -- -- -- -- -- K00803 AGPS, agpS alkyldihydroxyacetonephosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00803 Q9V778 451 1.6e-43 Alkyldihydroxyacetonephosphate synthase OS=Drosophila melanogaster GN=CG10253 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1233 Alkyl-dihydroxyacetonephosphate synthase Cluster-8309.23742 BF_2 277.00 3.05 4084 189241592 XP_971198.2 1208 2.2e-129 PREDICTED: serine/threonine-protein kinase 11-interacting protein [Tribolium castaneum]>gi|270001054|gb|EEZ97501.1| hypothetical protein TcasGA2_TC011344 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F479 472 2.0e-45 Serine/threonine-protein kinase 11-interacting protein OS=Gallus gallus GN=STK11IP PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG1859 Leucine-rich repeat proteins Cluster-8309.23743 BF_2 69.00 1.00 3173 642912878 XP_971323.2 692 1.2e-69 PREDICTED: EP300-interacting inhibitor of differentiation 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXX6 191 6.0e-13 Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens GN=NSMCE4A PE=1 SV=2 PF00790 VHS domain GO:0006886 intracellular protein transport -- -- -- -- KOG2866 Uncharacterized conserved protein Cluster-8309.23744 BF_2 28.00 8.46 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23746 BF_2 291.00 3.02 4324 642924359 XP_008194264.1 492 2.5e-46 PREDICTED: uncharacterized protein DDB_G0274915 [Tribolium castaneum]>gi|270006806|gb|EFA03254.1| hypothetical protein TcasGA2_TC013188 [Tribolium castaneum] -- -- -- -- -- K14307 NUPL1, NUP49 nucleoporin p58/p45 http://www.genome.jp/dbget-bin/www_bget?ko:K14307 Q9VDV3 206 1.5e-14 Probable nucleoporin Nup58 OS=Drosophila melanogaster GN=Nup58 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0845 Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) Cluster-8309.23749 BF_2 1.00 1.74 291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23751 BF_2 33.24 1.06 1596 478255734 ENN75943.1 1150 4.6e-123 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 P18155 878 6.6e-93 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Mus musculus GN=Mthfd2 PE=1 SV=1 PF00763//PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0055114//GO:0009396//GO:0046487 oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.23753 BF_2 155.78 2.02 3506 642936026 XP_008198274.1 900 9.9e-94 PREDICTED: ras-related protein Rab-37-like isoform X4 [Tribolium castaneum] 620970185 XM_001514705.3 39 3.32218e-08 PREDICTED: Ornithorhynchus anatinus ras-related protein Rab-39B (LOC100084248), mRNA K07914 RAB37 Ras-related protein Rab-37 http://www.genome.jp/dbget-bin/www_bget?ko:K07914 Q96AX2 733 9.5e-76 Ras-related protein Rab-37 OS=Homo sapiens GN=RAB37 PE=1 SV=3 PF03193//PF00503//PF00071//PF04670//PF08477//PF07728//PF01926//PF07475//PF00025//PF02421 Protein of unknown function, DUF258//G-protein alpha subunit//Ras family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//HPr Serine kinase C-terminal domain//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0000160//GO:0007165//GO:0006109//GO:0007186//GO:0015684//GO:0016310//GO:0007264 phosphorelay signal transduction system//signal transduction//regulation of carbohydrate metabolic process//G-protein coupled receptor signaling pathway//ferrous iron transport//phosphorylation//small GTPase mediated signal transduction GO:0031683//GO:0000155//GO:0005524//GO:0003924//GO:0019001//GO:0016887//GO:0015093//GO:0004871//GO:0005525//GO:0004672 G-protein beta/gamma-subunit complex binding//phosphorelay sensor kinase activity//ATP binding//GTPase activity//guanyl nucleotide binding//ATPase activity//ferrous iron transmembrane transporter activity//signal transducer activity//GTP binding//protein kinase activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.23756 BF_2 403.02 11.17 1797 634006865 AHZ59658.1 1592 2.9e-174 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1121 4.9e-121 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.23758 BF_2 27.00 0.32 3793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02116 Fungal pheromone mating factor STE2 GPCR GO:0019236//GO:0007606//GO:0007186 response to pheromone//sensory perception of chemical stimulus//G-protein coupled receptor signaling pathway GO:0004932 mating-type factor pheromone receptor activity GO:0016020 membrane -- -- Cluster-8309.23760 BF_2 9.64 0.79 800 642931467 XP_966826.3 451 2.6e-42 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.23765 BF_2 7.00 1.46 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23766 BF_2 28.49 1.37 1160 270004868 EFA01316.1 280 2.6e-22 hypothetical protein TcasGA2_TC003278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55918 226 1.9e-17 Microfibril-associated glycoprotein 4 OS=Bos taurus GN=MFAP4 PE=1 SV=2 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.23767 BF_2 590.14 5.60 4698 546680189 ERL90517.1 2265 7.0e-252 hypothetical protein D910_07865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15643 640 7.7e-65 Thyroid receptor-interacting protein 11 OS=Homo sapiens GN=TRIP11 PE=1 SV=3 PF01465//PF05440 GRIP domain//Tetrahydromethanopterin S-methyltransferase subunit B GO:0015948//GO:0000042//GO:0046656 methanogenesis//protein targeting to Golgi//folic acid biosynthetic process GO:0030269//GO:0005515 tetrahydromethanopterin S-methyltransferase activity//protein binding GO:0016021 integral component of membrane KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.23768 BF_2 1986.59 17.86 4940 478263926 ENN82092.1 3330 0.0e+00 hypothetical protein YQE_01525, partial [Dendroctonus ponderosae] -- -- -- -- -- K06111 EXOC4, SEC8L1 exocyst complex component 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06111 Q96A65 1435 5.3e-157 Exocyst complex component 4 OS=Homo sapiens GN=EXOC4 PE=1 SV=1 PF00326//PF08702//PF10392//PF07859//PF04048 Prolyl oligopeptidase family//Fibrinogen alpha/beta chain family//Golgi transport complex subunit 5//alpha/beta hydrolase fold//Sec8 exocyst complex component specific domain GO:0015031//GO:0006508//GO:0030168//GO:0006904//GO:0051258//GO:0008152//GO:0007165//GO:0006891 protein transport//proteolysis//platelet activation//vesicle docking involved in exocytosis//protein polymerization//metabolic process//signal transduction//intra-Golgi vesicle-mediated transport GO:0008236//GO:0030674//GO:0005102//GO:0016787 serine-type peptidase activity//protein binding, bridging//receptor binding//hydrolase activity GO:0005577//GO:0017119//GO:0000145 fibrinogen complex//Golgi transport complex//exocyst -- -- Cluster-8309.2377 BF_2 2.00 0.35 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23771 BF_2 75.95 0.61 5464 642936176 XP_008198328.1 1213 7.8e-130 PREDICTED: fibronectin type III domain-containing protein 4 [Tribolium castaneum] 194880702 XM_001974468.1 91 6.44308e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF00041//PF16656//PF08022 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//FAD-binding domain GO:0055114//GO:0019497//GO:0006771 oxidation-reduction process//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0016491//GO:0005515//GO:0003993 metal ion binding//oxidoreductase activity//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.23772 BF_2 26.19 0.31 3839 817051906 XP_012253468.1 1791 5.2e-197 PREDICTED: autophagy-related protein 16-1 isoform X2 [Athalia rosae] -- -- -- -- -- K17890 ATG16L autophagy-related protein 16, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17890 Q676U5 920 2.1e-97 Autophagy-related protein 16-1 OS=Homo sapiens GN=ATG16L1 PE=1 SV=2 PF08702//PF00400//PF00105//PF05837 Fibrinogen alpha/beta chain family//WD domain, G-beta repeat//Zinc finger, C4 type (two domains)//Centromere protein H (CENP-H) GO:0030168//GO:0006355//GO:0051258//GO:0007165//GO:0051382 platelet activation//regulation of transcription, DNA-templated//protein polymerization//signal transduction//kinetochore assembly GO:0003700//GO:0005102//GO:0043565//GO:0030674//GO:0008270//GO:0005515 transcription factor activity, sequence-specific DNA binding//receptor binding//sequence-specific DNA binding//protein binding, bridging//zinc ion binding//protein binding GO:0005577//GO:0000776//GO:0005667//GO:0005634 fibrinogen complex//kinetochore//transcription factor complex//nucleus KOG0288 WD40 repeat protein TipD Cluster-8309.23773 BF_2 20.72 0.33 2877 642930890 XP_008196128.1 328 1.7e-27 PREDICTED: protein-methionine sulfoxide oxidase MICAL3 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 208 5.8e-15 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23775 BF_2 13.00 0.56 1267 270013601 EFA10049.1 270 4.0e-21 hypothetical protein TcasGA2_TC012223 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02455 131 2.2e-06 Protein MLP1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=MLP1 PE=1 SV=2 PF04513//PF01442 Baculovirus polyhedron envelope protein, PEP, C terminus//Apolipoprotein A1/A4/E domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005198//GO:0008289 structural molecule activity//lipid binding GO:0019031//GO:0005576//GO:0019028 viral envelope//extracellular region//viral capsid -- -- Cluster-8309.23777 BF_2 10.24 0.34 1532 642926079 XP_008194755.1 188 1.6e-11 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09003 Bacteriophage lambda integrase, N-terminal domain GO:0015074 DNA integration GO:0003677//GO:0008907 DNA binding//integrase activity -- -- -- -- Cluster-8309.23778 BF_2 112.00 2.08 2543 642935733 XP_008198149.1 467 1.2e-43 PREDICTED: proteoglycan 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03127//PF00010 GAT domain//Helix-loop-helix DNA-binding domain GO:0006886 intracellular protein transport GO:0046983 protein dimerization activity GO:0005622 intracellular -- -- Cluster-8309.23782 BF_2 72.07 1.07 3117 332376603 AEE63441.1 1462 6.0e-159 unknown [Dendroctonus ponderosae]>gi|478266236|gb|ENN82734.1| hypothetical protein YQE_00898, partial [Dendroctonus ponderosae]>gi|478269355|gb|ENN83336.1| hypothetical protein YQE_00305, partial [Dendroctonus ponderosae]>gi|546686950|gb|ERL95923.1| hypothetical protein D910_00603 [Dendroctonus ponderosae]>gi|546687121|gb|ERL96001.1| hypothetical protein D910_00781 [Dendroctonus ponderosae]>gi|546687373|gb|ERL96110.1| hypothetical protein D910_01059 [Dendroctonus ponderosae] -- -- -- -- -- K18173 COA1 cytochrome c oxidase assembly factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18173 Q49LS4 393 2.2e-36 XK-related protein 4 OS=Pan troglodytes GN=XKR4 PE=2 SV=1 PF09815//PF01964//PF08294 XK-related protein//Radical SAM ThiC family//TIM21 GO:0009228//GO:0030150 thiamine biosynthetic process//protein import into mitochondrial matrix GO:0051536 iron-sulfur cluster binding GO:0005744//GO:0016021 mitochondrial inner membrane presequence translocase complex//integral component of membrane -- -- Cluster-8309.23783 BF_2 488.82 7.06 3182 332376603 AEE63441.1 1462 6.1e-159 unknown [Dendroctonus ponderosae]>gi|478266236|gb|ENN82734.1| hypothetical protein YQE_00898, partial [Dendroctonus ponderosae]>gi|478269355|gb|ENN83336.1| hypothetical protein YQE_00305, partial [Dendroctonus ponderosae]>gi|546686950|gb|ERL95923.1| hypothetical protein D910_00603 [Dendroctonus ponderosae]>gi|546687121|gb|ERL96001.1| hypothetical protein D910_00781 [Dendroctonus ponderosae]>gi|546687373|gb|ERL96110.1| hypothetical protein D910_01059 [Dendroctonus ponderosae] -- -- -- -- -- K18173 COA1 cytochrome c oxidase assembly factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18173 Q49LS4 393 2.3e-36 XK-related protein 4 OS=Pan troglodytes GN=XKR4 PE=2 SV=1 PF09815//PF08294//PF01964 XK-related protein//TIM21//Radical SAM ThiC family GO:0009228//GO:0030150 thiamine biosynthetic process//protein import into mitochondrial matrix GO:0051536 iron-sulfur cluster binding GO:0005744//GO:0016021 mitochondrial inner membrane presequence translocase complex//integral component of membrane -- -- Cluster-8309.23786 BF_2 10.48 0.75 870 478257946 ENN78084.1 540 1.4e-52 hypothetical protein YQE_05238, partial [Dendroctonus ponderosae] 556999212 XM_006002594.1 131 5.76839e-60 PREDICTED: Latimeria chalumnae RAB2A, member RAS oncogene family (RAB2A), mRNA K07877 RAB2A Ras-related protein Rab-2A http://www.genome.jp/dbget-bin/www_bget?ko:K07877 Q90965 526 2.4e-52 Ras-related protein Rab-2A OS=Gallus gallus GN=RAB2A PE=2 SV=1 PF04670//PF00025//PF00071//PF01926//PF08477 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.23787 BF_2 1.00 0.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23791 BF_2 164.86 1.31 5571 657571509 XP_008289328.1 264 8.8e-20 PREDICTED: uncharacterized protein LOC103364096, partial [Stegastes partitus] 642937236 XM_008200529.1 145 6.29704e-67 PREDICTED: Tribolium castaneum zinc finger protein 1 (LOC100141776), transcript variant X4, mRNA K09299 ZEB1_2 zinc finger homeobox protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K09299 Q03936 256 3.1e-20 Zinc finger protein 92 OS=Homo sapiens GN=ZNF92 PE=2 SV=2 PF13912//PF05920//PF00096//PF13465//PF00046//PF01155 C2H2-type zinc finger//Homeobox KN domain//Zinc finger, C2H2 type//Zinc-finger double domain//Homeobox domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006355 cellular protein modification process//regulation of transcription, DNA-templated GO:0016151//GO:0046872//GO:0003677 nickel cation binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.23792 BF_2 31.00 2.98 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23793 BF_2 124.00 6.64 1068 642923459 XP_008193754.1 209 4.0e-14 PREDICTED: uncharacterized protein LOC100142497 isoform X1 [Tribolium castaneum]>gi|270007012|gb|EFA03460.1| hypothetical protein TcasGA2_TC013455 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23794 BF_2 152.00 6.06 1337 91092772 XP_973748.1 708 6.9e-72 PREDICTED: R3H domain-containing protein 4 [Tribolium castaneum]>gi|270014788|gb|EFA11236.1| hypothetical protein TcasGA2_TC010768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KIL7 213 7.1e-16 R3H domain-containing protein 4 OS=Bos taurus GN=R3HDM4 PE=2 SV=1 PF09171//PF01424 Domain of unknown function (DUF1886)//R3H domain GO:0006284 base-excision repair GO:0016799//GO:0003676//GO:0003906 hydrolase activity, hydrolyzing N-glycosyl compounds//nucleic acid binding//DNA-(apurinic or apyrimidinic site) lyase activity -- -- -- -- Cluster-8309.23795 BF_2 22.55 0.65 1748 642915041 XP_008190385.1 305 4.9e-25 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like [Tribolium castaneum] -- -- -- -- -- K08059 IFI30, GILT interferon, gamma-inducible protein 30 http://www.genome.jp/dbget-bin/www_bget?ko:K08059 A6QPN6 218 2.5e-16 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.23798 BF_2 165.00 10.03 975 91084821 XP_973367.1 326 1.0e-27 PREDICTED: methylated-DNA--protein-cysteine methyltransferase [Tribolium castaneum]>gi|270008961|gb|EFA05409.1| hypothetical protein TcasGA2_TC015585 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26189 247 6.0e-20 Regulatory protein ada OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=ada PE=3 SV=2 PF01035 6-O-methylguanine DNA methyltransferase, DNA binding domain GO:0006281 DNA repair GO:0003824 catalytic activity -- -- KOG4062 6-O-methylguanine-DNA methyltransferase MGMT/MGT1, involved in DNA repair Cluster-8309.23799 BF_2 352.99 11.78 1541 189241005 XP_969371.2 1128 1.6e-120 PREDICTED: polymerase delta-interacting protein 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY77 183 2.5e-12 Polymerase delta-interacting protein 3 OS=Homo sapiens GN=POLDIP3 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.23800 BF_2 503.58 6.58 3491 642924747 XP_008194424.1 4197 0.0e+00 PREDICTED: tyrosine-protein kinase PR2 isoform X3 [Tribolium castaneum] 462376521 APGK01023661.1 50 2.53908e-14 Dendroctonus ponderosae Seq01023671, whole genome shotgun sequence -- -- -- -- Q9I7F7 1702 4.1e-188 Tyrosine-protein kinase PR2 OS=Drosophila melanogaster GN=PR2 PE=1 SV=3 PF07714//PF00069//PF14604//PF00018//PF03943 Protein tyrosine kinase//Protein kinase domain//Variant SH3 domain//SH3 domain//TAP C-terminal domain GO:0051028//GO:0006468 mRNA transport//protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0005634 nucleus KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.23805 BF_2 5.00 0.70 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23808 BF_2 13.67 0.84 971 861609140 KMQ84926.1 715 7.8e-73 isoform g [Lasius niger] 268574973 XM_002642420.1 86 6.69808e-35 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 602 4.1e-61 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF01517//PF03938//PF16326//PF04111//PF00769//PF01496 Hepatitis delta virus delta antigen//Outer membrane protein (OmpH-like)//ABC transporter C-terminal domain//Autophagy protein Apg6//Ezrin/radixin/moesin family//V-type ATPase 116kDa subunit family GO:0015991//GO:0006914//GO:0015992 ATP hydrolysis coupled proton transport//autophagy//proton transport GO:0003677//GO:0003723//GO:0008092//GO:0015078//GO:0051082 DNA binding//RNA binding//cytoskeletal protein binding//hydrogen ion transmembrane transporter activity//unfolded protein binding GO:0042025//GO:0019898//GO:0005737//GO:0033179 host cell nucleus//extrinsic component of membrane//cytoplasm//proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.23809 BF_2 33.01 0.31 4684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23811 BF_2 3.00 0.67 475 332372484 AEE61384.1 647 2.9e-65 unknown [Dendroctonus ponderosae]>gi|478263185|gb|ENN81578.1| hypothetical protein YQE_02107, partial [Dendroctonus ponderosae]>gi|546681813|gb|ERL91839.1| hypothetical protein D910_09164 [Dendroctonus ponderosae] -- -- -- -- -- K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00508 545 8.1e-55 Aspartate aminotransferase, mitochondrial OS=Gallus gallus GN=GOT2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.23814 BF_2 87.00 4.40 1114 391340346 XP_003744503.1 427 2.2e-39 PREDICTED: uncharacterized protein LOC100899845 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23815 BF_2 2.00 0.50 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23816 BF_2 6868.83 34.51 8614 560135523 CDJ84245.1 2272 2.0e-252 Protein of unknown function DUF889 domain containing protein [Haemonchus contortus] -- -- -- -- -- -- -- -- -- Q7ZV90 255 6.2e-20 ATP-dependent DNA helicase PIF1 OS=Danio rerio GN=pif1 PE=2 SV=1 PF05970//PF01443//PF02689 PIF1-like helicase//Viral (Superfamily 1) RNA helicase//Helicase GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0005524//GO:0003678//GO:0004386 ATP binding//DNA helicase activity//helicase activity GO:0005657 replication fork -- -- Cluster-8309.2382 BF_2 35.00 0.95 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23820 BF_2 141.27 0.86 7140 642935193 XP_008199686.1 2675 3.0e-299 PREDICTED: ATP-dependent RNA helicase abstrakt [Tribolium castaneum] 665786806 XM_008556015.1 412 0 PREDICTED: Microplitis demolitor ATP-dependent RNA helicase abstrakt (LOC103575994), mRNA K13116 DDX41, ABS ATP-dependent RNA helicase DDX41 http://www.genome.jp/dbget-bin/www_bget?ko:K13116 Q9V3C0 2220 7.2e-248 ATP-dependent RNA helicase abstrakt OS=Drosophila melanogaster GN=abs PE=1 SV=1 PF00098//PF11789//PF00096//PF01805//PF06862//PF04851//PF06220//PF00270 Zinc knuckle//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C2H2 type//Surp module//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Type III restriction enzyme, res subunit//U1 zinc finger//DEAD/DEAH box helicase GO:0006396 RNA processing GO:0046872//GO:0008270//GO:0003676//GO:0005524//GO:0003723//GO:0016787//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//ATP binding//RNA binding//hydrolase activity//DNA binding GO:0005634 nucleus KOG0341 DEAD-box protein abstrakt Cluster-8309.23821 BF_2 774.09 4.17 8054 91080871 XP_972325.1 2663 8.4e-298 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.0e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF07645//PF00008//PF01731//PF06119 Calcium-binding EGF domain//EGF-like domain//Arylesterase//Nidogen-like GO:0007160 cell-matrix adhesion GO:0005509//GO:0004064//GO:0005515 calcium ion binding//arylesterase activity//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.23822 BF_2 96.07 0.87 4913 642916006 XP_008190854.1 2795 0.0e+00 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23824 BF_2 21.54 0.32 3066 642939434 XP_008200389.1 2831 0.0e+00 PREDICTED: pumilio homolog 2 isoform X2 [Tribolium castaneum] 795073953 XM_012020518.1 65 1.02145e-22 PREDICTED: Vollenhovia emeryi pumilio homolog 2 (LOC105566474), transcript variant X5, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 E3WDQ9 1070 6.9e-115 Pumilio homolog 2 OS=Xenopus laevis GN=pum2 PE=1 SV=1 PF00806//PF04627//PF01151 Pumilio-family RNA binding repeat//Mitochondrial ATP synthase epsilon chain//GNS1/SUR4 family GO:0015992//GO:0015986//GO:0006119 proton transport//ATP synthesis coupled proton transport//oxidative phosphorylation GO:0046933//GO:0046961//GO:0003723 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//RNA binding GO:0045259//GO:0000275//GO:0016021 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//integral component of membrane KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.23826 BF_2 39.13 0.63 2906 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03639 Glycosyl hydrolase family 81 GO:0016998 cell wall macromolecule catabolic process GO:0052862//GO:0052861 glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group//glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group -- -- -- -- Cluster-8309.23829 BF_2 6.08 0.32 1078 91083111 XP_970182.1 844 9.5e-88 PREDICTED: L-galactose dehydrogenase [Tribolium castaneum]>gi|270007677|gb|EFA04125.1| hypothetical protein TcasGA2_TC014368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O81884 390 1.7e-36 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1576 Predicted oxidoreductase Cluster-8309.23832 BF_2 198.05 14.34 865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23833 BF_2 89.00 1.95 2201 642931027 XP_008196184.1 549 3.1e-53 PREDICTED: uncharacterized protein LOC103313791 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8X679 285 5.3e-24 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF02176//PF07967//PF03145 TRAF-type zinc finger//C3HC zinc finger-like//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.23835 BF_2 114.26 1.21 4248 642919707 XP_008192031.1 344 3.6e-29 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 [Tribolium castaneum] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 312 7.5e-27 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-8309.23836 BF_2 12.05 0.52 1265 270015414 EFA11862.1 319 8.4e-27 hypothetical protein TcasGA2_TC005104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04048 Sec8 exocyst complex component specific domain GO:0006904//GO:0015031 vesicle docking involved in exocytosis//protein transport -- -- GO:0000145 exocyst -- -- Cluster-8309.23838 BF_2 39.00 1.33 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23839 BF_2 40.00 0.80 2375 288816877 ADC55251.1 2552 1.8e-285 mitochondrial ATP synthase subunit alpha precursor [Litopenaeus vannamei] 327204527 GQ848643.3 1083 0 Litopenaeus vannamei mitochondrial ATP synthase subunit alpha precursor, mRNA, complete cds; nuclear gene for mitochondrial product K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 P35381 2290 1.8e-256 ATP synthase subunit alpha, mitochondrial OS=Drosophila melanogaster GN=blw PE=1 SV=2 PF00306//PF00006//PF02874 ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta family, beta-barrel domain GO:0046034//GO:0015992//GO:0015991 ATP metabolic process//proton transport//ATP hydrolysis coupled proton transport GO:0016820//GO:0005524 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//ATP binding GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-8309.23840 BF_2 17.02 0.53 1631 728418784 AIY68381.1 302 1.0e-24 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P12992 200 2.8e-14 Juvenile hormone esterase OS=Heliothis virescens PE=1 SV=2 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.23841 BF_2 14.94 1.05 885 642924004 XP_008193965.1 253 2.6e-19 PREDICTED: WD repeat-containing protein 89 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.23842 BF_2 32.00 0.50 2946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06072//PF11815 Alphaherpesvirus tegument protein US9//Domain of unknown function (DUF3336) GO:0046486//GO:0006629//GO:0016042 glycerolipid metabolic process//lipid metabolic process//lipid catabolic process GO:0004806 triglyceride lipase activity GO:0019033 viral tegument -- -- Cluster-8309.23844 BF_2 469.67 5.60 3797 642932696 XP_008196948.1 1875 9.4e-207 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10473//PF17085//PF06371//PF06367//PF02183 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Unique cartilage matrix associated protein//Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Homeobox associated leucine zipper GO:0030036//GO:0006355//GO:0016043//GO:0045667 actin cytoskeleton organization//regulation of transcription, DNA-templated//cellular component organization//regulation of osteoblast differentiation GO:0003700//GO:0017048//GO:0042803//GO:0043565//GO:0045502//GO:0003779//GO:0008134 transcription factor activity, sequence-specific DNA binding//Rho GTPase binding//protein homodimerization activity//sequence-specific DNA binding//dynein binding//actin binding//transcription factor binding GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.23850 BF_2 41.83 7.74 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23853 BF_2 241.00 9.24 1378 733929037 XP_010725335.1 174 6.0e-10 PREDICTED: mucin-21-like [Meleagris gallopavo] -- -- -- -- -- -- -- -- -- P40954 130 3.1e-06 Chitinase 3 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=CHT3 PE=1 SV=2 PF01442//PF06426 Apolipoprotein A1/A4/E domain//Serine acetyltransferase, N-terminal GO:0042967//GO:0006534//GO:0006869//GO:0042157//GO:0006535 acyl-carrier-protein biosynthetic process//cysteine metabolic process//lipid transport//lipoprotein metabolic process//cysteine biosynthetic process from serine GO:0008289//GO:0009001 lipid binding//serine O-acetyltransferase activity GO:0005737//GO:0005576 cytoplasm//extracellular region -- -- Cluster-8309.23854 BF_2 249.00 17.11 896 332376162 AEE63221.1 792 8.4e-82 unknown [Dendroctonus ponderosae]>gi|478261356|gb|ENN80760.1| hypothetical protein YQE_02821, partial [Dendroctonus ponderosae]>gi|546678771|gb|ERL89323.1| hypothetical protein D910_06695 [Dendroctonus ponderosae] -- -- -- -- -- K05756 ARPC3 actin related protein 2/3 complex, subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05756 Q9JM76 631 1.6e-64 Actin-related protein 2/3 complex subunit 3 OS=Mus musculus GN=Arpc3 PE=1 SV=3 PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005885//GO:0005856 Arp2/3 protein complex//cytoskeleton KOG3155 Actin-related protein Arp2/3 complex, subunit ARPC3 Cluster-8309.23857 BF_2 39.54 0.98 1977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23858 BF_2 171.73 0.98 7587 189241213 XP_970686.2 2041 1.1e-225 PREDICTED: peroxisomal targeting signal 1 receptor isoform X1 [Tribolium castaneum]>gi|270013260|gb|EFA09708.1| hypothetical protein TcasGA2_TC011841 [Tribolium castaneum] 462302391 APGK01050245.1 50 5.54675e-14 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1125 7.2e-121 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF00638//PF02064//PF13181//PF13371//PF00515//PF13374//PF00400//PF13176//PF13414 RanBP1 domain//MAS20 protein import receptor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//TPR repeat GO:0006886//GO:0046907//GO:0006605 intracellular protein transport//intracellular transport//protein targeting GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.23865 BF_2 29.00 1.92 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23866 BF_2 228.92 1.67 6023 270000847 EEZ97294.1 1566 1.0e-170 hypothetical protein TcasGA2_TC011099 [Tribolium castaneum] 642937258 XM_008200538.1 171 2.39832e-81 PREDICTED: Tribolium castaneum mucin-2 (LOC657242), mRNA -- -- -- -- -- -- -- -- PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.23867 BF_2 2.00 0.37 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11857//PF11837//PF02468 Domain of unknown function (DUF3377)//Domain of unknown function (DUF3357)//Photosystem II reaction centre N protein (psbN) GO:0006012//GO:0005985//GO:0015979//GO:0005982 galactose metabolic process//sucrose metabolic process//photosynthesis//starch metabolic process GO:0004564//GO:0004575//GO:0004222 beta-fructofuranosidase activity//sucrose alpha-glucosidase activity//metalloendopeptidase activity GO:0009539//GO:0009523//GO:0016020//GO:0017177 photosystem II reaction center//photosystem II//membrane//glucosidase II complex -- -- Cluster-8309.23868 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23871 BF_2 36.17 0.40 4045 642910866 XP_001813884.2 1865 1.4e-205 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1157 7.5e-125 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF00103//PF02390//PF04977//PF08123 Somatotropin hormone family//Putative methyltransferase//Septum formation initiator//Histone methylation protein DOT1 GO:0007165//GO:0006479//GO:0009451//GO:0007049//GO:0006400//GO:0008033//GO:0006554 signal transduction//protein methylation//RNA modification//cell cycle//tRNA modification//tRNA processing//lysine catabolic process GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.23874 BF_2 81.00 4.93 975 642914664 XP_008190305.1 775 8.6e-80 PREDICTED: peptidyl-prolyl cis-trans isomerase-like 3 [Tribolium castaneum] -- -- -- -- -- K12734 PPIL3 peptidyl-prolyl cis-trans isomerase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12734 Q9H2H8 720 8.4e-75 Peptidyl-prolyl cis-trans isomerase-like 3 OS=Homo sapiens GN=PPIL3 PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0884 Similar to cyclophilin-type peptidyl-prolyl cis-trans isomerase Cluster-8309.23878 BF_2 25.63 0.57 2157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04573 Signal peptidase subunit GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.23880 BF_2 9.62 0.35 1437 270005345 EFA01793.1 658 4.7e-66 hypothetical protein TcasGA2_TC007394 [Tribolium castaneum] -- -- -- -- -- K12337 MRVI1, IRAG inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate http://www.genome.jp/dbget-bin/www_bget?ko:K12337 Q5RHB5 170 7.4e-11 Lymphoid-restricted membrane protein OS=Danio rerio GN=lrmp PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23882 BF_2 44.02 0.69 2961 478254857 ENN75093.1 225 1.6e-15 hypothetical protein YQE_08406, partial [Dendroctonus ponderosae] -- -- -- -- -- K14394 ACP1 low molecular weight phosphotyrosine protein phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14394 P82890 176 3.1e-11 Low molecular weight phosphotyrosine protein phosphatase 1 OS=Drosophila melanogaster GN=primo-1 PE=2 SV=1 PF00961 LAGLIDADG endonuclease -- -- GO:0004519 endonuclease activity -- -- KOG3217 Protein tyrosine phosphatase Cluster-8309.23883 BF_2 314.72 6.12 2437 642928421 XP_008193780.1 3184 0.0e+00 PREDICTED: probable cleavage and polyadenylation specificity factor subunit 2 [Tribolium castaneum]>gi|270010824|gb|EFA07272.1| hypothetical protein TcasGA2_TC014506 [Tribolium castaneum] 665813545 XM_008557111.1 256 5.3972e-129 PREDICTED: Microplitis demolitor probable cleavage and polyadenylation specificity factor subunit 2 (LOC103576746), mRNA K14402 CPSF2, CFT2 cleavage and polyadenylation specificity factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14402 Q9V3D6 2508 9.9e-282 Probable cleavage and polyadenylation specificity factor subunit 2 OS=Drosophila melanogaster GN=Cpsf100 PE=1 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1135 mRNA cleavage and polyadenylation factor II complex, subunit CFT2 (CPSF subunit) Cluster-8309.23884 BF_2 2.00 0.37 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23887 BF_2 308.50 5.08 2827 642934418 XP_008197653.1 541 3.4e-52 PREDICTED: transformer-2 protein homolog beta isoform X4 [Tribolium castaneum] 642934415 XM_008199430.1 258 4.84646e-130 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X3, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 2.5e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF00076//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0118 FOG: RRM domain Cluster-8309.23889 BF_2 1.00 21.50 215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05051 Cytochrome C oxidase copper chaperone (COX17) GO:0006825 copper ion transport GO:0005507//GO:0016531 copper ion binding//copper chaperone activity GO:0005758 mitochondrial intermembrane space -- -- Cluster-8309.23890 BF_2 56.14 1.16 2309 642933530 XP_008197457.1 904 2.2e-94 PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933532|ref|XP_008197458.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933534|ref|XP_008197459.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum] 462283408 APGK01056946.1 55 2.7776e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 6.6e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF07267//PF09726//PF00076 Nucleopolyhedrovirus capsid protein P87//Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4733 FOG: RRM domain Cluster-8309.23894 BF_2 2.00 0.63 419 642924469 XP_008194311.1 355 1.9e-31 PREDICTED: transcription factor Sox-2 [Tribolium castaneum]>gi|270008130|gb|EFA04578.1| Sox21b [Tribolium castaneum] 642924468 XM_008196089.1 169 2.00211e-81 PREDICTED: Tribolium castaneum transcription factor Sox-2 (LOC660661), mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q24533 177 3.3e-12 SOX domain-containing protein dichaete OS=Drosophila melanogaster GN=D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.23897 BF_2 80.11 0.59 5958 642920697 XP_008192527.1 407 2.5e-36 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06546 Vertebrate heat shock transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.23901 BF_2 351.63 3.86 4094 642911219 XP_008199637.1 1875 1.0e-206 PREDICTED: FCH domain only protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502I9 789 3.5e-82 F-BAR domain only protein 2 OS=Danio rerio GN=fcho2 PE=2 SV=1 PF02662//PF01442//PF13326//PF02050 Methyl-viologen-reducing hydrogenase, delta subunit//Apolipoprotein A1/A4/E domain//Photosystem II Pbs27//Flagellar FliJ protein GO:0055114//GO:0010207//GO:0071973//GO:0006869//GO:0015948//GO:0042157//GO:0006935 oxidation-reduction process//photosystem II assembly//bacterial-type flagellum-dependent cell motility//lipid transport//methanogenesis//lipoprotein metabolic process//chemotaxis GO:0003774//GO:0008289 motor activity//lipid binding GO:0005576//GO:0009288//GO:0016020 extracellular region//bacterial-type flagellum//membrane KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.23902 BF_2 11.12 0.52 1176 817079505 XP_012262173.1 280 2.6e-22 PREDICTED: zinc finger protein 706-like [Athalia rosae]>gi|817079507|ref|XP_012262174.1| PREDICTED: zinc finger protein 706-like [Athalia rosae] 389609616 AK401798.1 81 4.90732e-32 Papilio xuthus mRNA for similar to CG15715, complete cds, sequence id: Px-1382 -- -- -- -- Q5ZMM5 201 1.5e-14 Zinc finger protein 706 OS=Gallus gallus GN=ZNF706 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4118 Uncharacterized conserved protein Cluster-8309.23903 BF_2 6.00 1.14 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23904 BF_2 18.26 2.05 659 91076494 XP_972946.1 216 3.8e-15 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88668 135 3.9e-07 Protein CREG1 OS=Mus musculus GN=Creg1 PE=2 SV=1 -- -- GO:0055114 oxidation-reduction process GO:0010181//GO:0016491 FMN binding//oxidoreductase activity -- -- -- -- Cluster-8309.23905 BF_2 128.74 40.31 420 270011573 EFA08021.1 284 3.2e-23 hypothetical protein TcasGA2_TC005610 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23907 BF_2 259.78 6.51 1956 91088923 XP_973277.1 1071 8.2e-114 PREDICTED: lysophospholipid acyltransferase 7 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 Q5U4T9 604 4.8e-61 Lysophospholipid acyltransferase 7 OS=Xenopus laevis GN=mboat7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2706 Predicted membrane protein Cluster-8309.23909 BF_2 73.41 0.92 3618 780649216 XP_011689959.1 1077 3.1e-114 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00589 Phage integrase family GO:0015074//GO:0006310 DNA integration//DNA recombination GO:0003677 DNA binding -- -- -- -- Cluster-8309.23912 BF_2 5.00 0.67 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23913 BF_2 209.62 2.01 4651 340717680 XP_003397307.1 2904 0.0e+00 PREDICTED: protein O-GlcNAcase [Bombus terrestris] 830022072 XM_012723671.1 44 7.34144e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 2.9e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF00736//PF05418//PF09726 EF-1 guanine nucleotide exchange domain//Apovitellenin I (Apo-VLDL-II)//Transmembrane protein GO:0006414//GO:0006629//GO:0006448 translational elongation//lipid metabolic process//regulation of translational elongation GO:0003746//GO:0004857 translation elongation factor activity//enzyme inhibitor activity GO:0005840//GO:0005853//GO:0042627//GO:0016021 ribosome//eukaryotic translation elongation factor 1 complex//chylomicron//integral component of membrane KOG3698 Hyaluronoglucosaminidase Cluster-8309.23915 BF_2 42.53 0.41 4610 478251870 ENN72309.1 1219 1.3e-130 hypothetical protein YQE_11052, partial [Dendroctonus ponderosae] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 943 5.5e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF14750//PF09445//PF02086//PF02875//PF08241 Integrator complex subunit 2//RNA cap guanine-N2 methyltransferase//D12 class N6 adenine-specific DNA methyltransferase//Mur ligase family, glutamate ligase domain//Methyltransferase domain GO:0006306//GO:0009058//GO:0001510//GO:0009452//GO:0032775//GO:0008152 DNA methylation//biosynthetic process//RNA methylation//7-methylguanosine RNA capping//DNA methylation on adenine//metabolic process GO:0008168//GO:0009007//GO:0005524//GO:0016874 methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//ATP binding//ligase activity GO:0032039 integrator complex KOG2078 tRNA modification enzyme Cluster-8309.23917 BF_2 5.00 1.43 433 332374226 AEE62254.1 347 1.6e-30 unknown [Dendroctonus ponderosae]>gi|546682528|gb|ERL92451.1| hypothetical protein D910_09765 [Dendroctonus ponderosae] 346714041 AK384569.1 98 6.10441e-42 Bombyx mori mRNA, clone: fcaL28G17 K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 P48588 327 1.4e-29 40S ribosomal protein S25 OS=Drosophila melanogaster GN=RpS25 PE=1 SV=3 PF01399//PF01325 PCI domain//Iron dependent repressor, N-terminal DNA binding domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG1767 40S ribosomal protein S25 Cluster-8309.23919 BF_2 184.00 13.16 872 642919649 XP_008192006.1 626 1.5e-62 PREDICTED: breast cancer metastasis-suppressor 1-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K19196 BRMS1 breast cancer metastasis-suppressor 1 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K19196 Q5ZLL9 386 4.1e-36 Breast cancer metastasis-suppressor 1-like protein OS=Gallus gallus GN=BRMS1L PE=2 SV=1 PF04546 Sigma-70, non-essential region GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0016987 transcription factor activity, sequence-specific DNA binding//DNA binding//sigma factor activity GO:0005667 transcription factor complex -- -- Cluster-8309.23920 BF_2 21.01 0.74 1474 612063312 XP_007505910.1 496 2.9e-47 PREDICTED: zinc finger protein 420-like [Monodelphis domestica] -- -- -- -- -- -- -- -- -- Q6ZMW2 479 1.1e-46 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF04810//PF02892//PF01363//PF13912//PF01428//PF01844//PF16622//PF05191//PF10503//PF13465//PF06467//PF14528//PF00096//PF01155//PF00130 Sec23/Sec24 zinc finger//BED zinc finger//FYVE zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//HNH endonuclease//zinc-finger C2H2-type//Adenylate kinase, active site lid//Esterase PHB depolymerase//Zinc-finger double domain//MYM-type Zinc finger with FCS sequence motif//LAGLIDADG-like domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006886//GO:0006888//GO:0046034//GO:0006144//GO:0006464//GO:0035556 intracellular protein transport//ER to Golgi vesicle-mediated transport//ATP metabolic process//purine nucleobase metabolic process//cellular protein modification process//intracellular signal transduction GO:0016151//GO:0003677//GO:0004519//GO:0046872//GO:0004017//GO:0003676//GO:0008270 nickel cation binding//DNA binding//endonuclease activity//metal ion binding//adenylate kinase activity//nucleic acid binding//zinc ion binding GO:0030127//GO:0005576 COPII vesicle coat//extracellular region -- -- Cluster-8309.23922 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23925 BF_2 2.62 1.71 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23926 BF_2 48.54 4.67 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23927 BF_2 66.75 0.73 4099 91083607 XP_969406.1 899 1.5e-93 PREDICTED: solute carrier family 25 member 44 [Tribolium castaneum]>gi|270007841|gb|EFA04289.1| hypothetical protein TcasGA2_TC014580 [Tribolium castaneum] -- -- -- -- -- K15121 SLC25A44 solute carrier family 25, member 44 http://www.genome.jp/dbget-bin/www_bget?ko:K15121 Q5RD67 494 5.7e-48 Solute carrier family 25 member 44 OS=Pongo abelii GN=SLC25A44 PE=2 SV=2 PF00096 Zinc finger, C2H2 type GO:0055085 transmembrane transport GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG0765 Predicted mitochondrial carrier protein Cluster-8309.2393 BF_2 9.00 0.94 689 125629114 CAL23143.2 604 4.1e-60 gustatory receptor candidate 10 [Tribolium castaneum]>gi|157885911|emb|CAL23172.3| gustatory receptor candidate 39 [Tribolium castaneum]>gi|270011146|gb|EFA07594.1| gustatory receptor 1 [Tribolium castaneum] -- -- -- -- -- K08471 GR gustatory receptor http://www.genome.jp/dbget-bin/www_bget?ko:K08471 Q7PMG3 503 8.7e-50 Gustatory and odorant receptor 22 OS=Anopheles gambiae GN=GPRgr22 PE=2 SV=1 PF08395 7tm Chemosensory receptor GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.23930 BF_2 16.73 0.76 1204 91083635 XP_970519.1 408 3.8e-37 PREDICTED: hydroxyacid oxidase 1 [Tribolium castaneum] 462320127 APGK01043802.1 62 1.83407e-21 Dendroctonus ponderosae Seq01043812, whole genome shotgun sequence K11517 HAO (S)-2-hydroxy-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K11517 Q9UJM8 285 2.9e-24 Hydroxyacid oxidase 1 OS=Homo sapiens GN=HAO1 PE=1 SV=1 PF01070 FMN-dependent dehydrogenase -- -- GO:0016491 oxidoreductase activity -- -- KOG0538 Glycolate oxidase Cluster-8309.23931 BF_2 58.30 2.11 1444 642915229 XP_008190531.1 1280 3.5e-138 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 828 3.7e-87 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF02793//PF13895 Hormone receptor domain//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016020 membrane -- -- Cluster-8309.23933 BF_2 3.82 0.71 511 91080669 XP_975087.1 498 5.9e-48 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 749780830 XM_011146479.1 92 1.57904e-38 PREDICTED: Harpegnathos saltator vesicle-trafficking protein SEC22b (LOC105186349), transcript variant X2, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 372 1.0e-34 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 -- -- GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.23934 BF_2 42.90 0.97 2140 91078844 XP_971675.1 341 4.0e-29 PREDICTED: leucine-rich repeat-containing protein 59 [Tribolium castaneum]>gi|270003717|gb|EFA00165.1| hypothetical protein TcasGA2_TC002987 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NWG1 202 2.2e-14 Leucine-rich repeat-containing protein 59 OS=Danio rerio GN=lrrc59 PE=2 SV=1 PF15715//PF07836 PCNA-associated factor//DmpG-like communication domain GO:0006974//GO:0051726//GO:0019439 cellular response to DNA damage stimulus//regulation of cell cycle//aromatic compound catabolic process GO:0016833 oxo-acid-lyase activity -- -- -- -- Cluster-8309.23936 BF_2 461.84 8.32 2610 642915624 XP_008190712.1 2597 1.2e-290 PREDICTED: protein tramtrack, beta isoform isoform X2 [Tribolium castaneum] 642915623 XM_008192490.1 419 0 PREDICTED: Tribolium castaneum protein tramtrack, beta isoform (LOC660343), transcript variant X4, mRNA -- -- -- -- Q9W0K7 396 8.4e-37 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF05007//PF02796//PF05225//PF00651 Mannosyltransferase (PIG-M)//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//BTB/POZ domain GO:0006506//GO:0006310 GPI anchor biosynthetic process//DNA recombination GO:0005515//GO:0000150//GO:0003677//GO:0016758 protein binding//recombinase activity//DNA binding//transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane -- -- Cluster-8309.23938 BF_2 11.85 0.43 1453 546679816 ERL90208.1 553 7.1e-54 hypothetical protein D910_07562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 476 2.5e-46 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.23939 BF_2 252.00 2.12 5256 390362249 XP_001190749.2 801 4.5e-82 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 734 1.1e-75 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF06451//PF13606//PF12537//PF00023 Moricin//Ankyrin repeat//The Golgi pH Regulator (GPHR) Family N-terminal//Ankyrin repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0016020//GO:0005576 membrane//extracellular region KOG4177 Ankyrin Cluster-8309.23949 BF_2 4.00 0.42 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23951 BF_2 29.00 3.94 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23952 BF_2 7.63 0.54 876 861633341 KMQ90932.1 264 1.4e-20 transposable element tc3 transposase [Lasius niger]>gi|861638451|gb|KMQ92508.1| transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23953 BF_2 8.00 2.05 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23957 BF_2 21.00 2.86 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23960 BF_2 11.00 2.01 516 752863744 XP_011268239.1 257 5.3e-20 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23965 BF_2 16.00 4.10 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23970 BF_2 338.10 14.16 1286 91077326 XP_974776.1 1025 1.2e-108 PREDICTED: pyrroline-5-carboxylate reductase 3 [Tribolium castaneum]>gi|270001668|gb|EEZ98115.1| hypothetical protein TcasGA2_TC000533 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q5SPD7 601 7.0e-61 Pyrroline-5-carboxylate reductase 3 OS=Danio rerio GN=pycrl PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006098//GO:0006525//GO:0006561//GO:0019521//GO:0055114 pentose-phosphate shunt//arginine metabolic process//proline biosynthetic process//D-gluconate metabolic process//oxidation-reduction process GO:0004735//GO:0000166//GO:0004616 pyrroline-5-carboxylate reductase activity//nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.23971 BF_2 98.00 2.33 2046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23972 BF_2 207.00 8.53 1302 436466 CAA82360.1 299 1.8e-24 putative transposase [Drosophila hydei]>gi|743805|prf||2013359A transposase -- -- -- -- -- -- -- -- -- Q04202 140 2.0e-07 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.23974 BF_2 71.68 1.49 2296 91088003 XP_973796.1 525 2.0e-50 PREDICTED: putative RNA-binding protein Luc7-like 2 [Tribolium castaneum]>gi|270011896|gb|EFA08344.1| hypothetical protein TcasGA2_TC005987 [Tribolium castaneum] -- -- -- -- -- K13212 LUC7L2 RNA-binding protein Luc7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13212 Q9Y383 397 5.7e-37 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 PF07851//PF03194//PF01442 TMPIT-like protein//LUC7 N_terminus//Apolipoprotein A1/A4/E domain GO:0042157//GO:0006376//GO:0006869 lipoprotein metabolic process//mRNA splice site selection//lipid transport GO:0003729//GO:0008289 mRNA binding//lipid binding GO:0005576//GO:0005685//GO:0016021 extracellular region//U1 snRNP//integral component of membrane KOG0796 Spliceosome subunit Cluster-8309.23976 BF_2 1.00 1.46 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23978 BF_2 821.55 8.29 4435 642914862 XP_008195074.1 2187 7.3e-243 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q28824 825 2.6e-86 Myosin light chain kinase, smooth muscle OS=Bos taurus GN=MYLK PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.23981 BF_2 186.00 4.25 2117 91083793 XP_972792.1 560 1.6e-54 PREDICTED: pre-mRNA-splicing factor CWC25 homolog [Tribolium castaneum]>gi|270006778|gb|EFA03226.1| hypothetical protein TcasGA2_TC013151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXE8 172 6.4e-11 Pre-mRNA-splicing factor CWC25 homolog OS=Homo sapiens GN=CWC25 PE=1 SV=1 PF04211 Tetrahydromethanopterin S-methyltransferase, subunit C GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane KOG3869 Uncharacterized conserved protein Cluster-8309.23982 BF_2 10.00 0.79 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23983 BF_2 18.22 0.63 1489 642922686 XP_008193280.1 161 2.1e-08 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98165 136 6.8e-07 Very low-density lipoprotein receptor OS=Gallus gallus GN=VLDLR PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.23986 BF_2 15.00 1.72 653 675368640 KFM61542.1 773 9.8e-80 60S ribosomal protein L13a, partial [Stegodyphus mimosarum] 212527809 XM_002144026.1 52 3.51882e-16 Penicillium marneffei ATCC 18224 60S ribosomal protein L16, partial mRNA K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 P40429 714 2.8e-74 60S ribosomal protein L13a OS=Homo sapiens GN=RPL13A PE=1 SV=2 PF01729//PF00572 Quinolinate phosphoribosyl transferase, C-terminal domain//Ribosomal protein L13 GO:0042254//GO:0046497//GO:0009435//GO:0006412 ribosome biogenesis//nicotinate nucleotide metabolic process//NAD biosynthetic process//translation GO:0003735//GO:0004514 structural constituent of ribosome//nicotinate-nucleotide diphosphorylase (carboxylating) activity GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-8309.23987 BF_2 3.00 0.33 673 861594808 KMQ83108.1 278 2.5e-22 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23989 BF_2 2.00 1.36 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23992 BF_2 46.00 2.57 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23995 BF_2 805.00 11.56 3199 189238859 XP_972488.2 1594 3.0e-174 PREDICTED: regulator of gene activity isoform X1 [Tribolium castaneum] 642927573 XM_967395.3 458 0 PREDICTED: Tribolium castaneum regulator of gene activity (LOC661220), transcript variant X1, mRNA K12605 CNOT2, NOT2 CCR4-NOT transcription complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12605 Q9NZN8 867 2.5e-91 CCR4-NOT transcription complex subunit 2 OS=Homo sapiens GN=CNOT2 PE=1 SV=1 PF04153 NOT2 / NOT3 / NOT5 family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2151 Predicted transcriptional regulator Cluster-8309.23997 BF_2 13.00 0.33 1917 391326427 XP_003737718.1 516 1.8e-49 PREDICTED: uncharacterized protein LOC100899732 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.23999 BF_2 2.00 2.63 304 546680927 ERL91101.1 236 8.5e-18 hypothetical protein D910_08443 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P42260 174 5.4e-12 Glutamate receptor ionotropic, kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 PF00060 Ligand-gated ion channel GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.24005 BF_2 87.08 1.43 2841 642916191 XP_008190924.1 2242 2.0e-249 PREDICTED: uncharacterized protein LOC662537 [Tribolium castaneum] 746862194 XM_011063702.1 155 8.81013e-73 PREDICTED: Acromyrmex echinatior uncharacterized LOC105150543 (LOC105150543), mRNA K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q8VHQ2 432 6.1e-41 Suppressor of cytokine signaling 7 OS=Mus musculus GN=Socs7 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.24006 BF_2 64.04 0.71 4065 642910948 XP_008193477.1 1972 5.7e-218 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 1403 2.2e-153 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF02897//PF00326 Prolyl oligopeptidase, N-terminal beta-propeller domain//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0070008//GO:0008236//GO:0004252 serine-type exopeptidase activity//serine-type peptidase activity//serine-type endopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.24007 BF_2 12.46 0.36 1723 332376855 AEE63567.1 453 3.3e-42 unknown [Dendroctonus ponderosae]>gi|478255772|gb|ENN75981.1| hypothetical protein YQE_07514, partial [Dendroctonus ponderosae]>gi|546680379|gb|ERL90658.1| hypothetical protein D910_08005 [Dendroctonus ponderosae] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q5EAC0 288 1.9e-24 Solute carrier family 25 member 38 OS=Bos taurus GN=SLC25A38 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0766 Predicted mitochondrial carrier protein Cluster-8309.24008 BF_2 983.67 14.19 3186 189236914 XP_969111.2 2409 9.5e-269 PREDICTED: alpha-(1,6)-fucosyltransferase [Tribolium castaneum]>gi|270006336|gb|EFA02784.1| hypothetical protein TcasGA2_TC008521 [Tribolium castaneum] 170044484 XM_001849824.1 190 3.45913e-92 Culex quinquefasciatus alpha-(1,6)-fucosyltransferase, mRNA K00717 FUT8 glycoprotein 6-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00717 Q9VYV5 1615 4.6e-178 Alpha-(1,6)-fucosyltransferase OS=Drosophila melanogaster GN=FucT6 PE=1 SV=1 PF03938//PF14604//PF09807 Outer membrane protein (OmpH-like)//Variant SH3 domain//Elongation complex protein 6 -- -- GO:0005515//GO:0051082 protein binding//unfolded protein binding GO:0033588 Elongator holoenzyme complex KOG3705 Glycoprotein 6-alpha-L-fucosyltransferase Cluster-8309.24009 BF_2 137.00 2.92 2253 91084147 XP_970126.1 1360 2.9e-147 PREDICTED: decaprenyl-diphosphate synthase subunit 2 [Tribolium castaneum]>gi|642925102|ref|XP_008194170.1| PREDICTED: decaprenyl-diphosphate synthase subunit 2 [Tribolium castaneum]>gi|270008055|gb|EFA04503.1| hypothetical protein TcasGA2_TC014811 [Tribolium castaneum] -- -- -- -- -- K12505 PDSS2 decaprenyl-diphosphate synthase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12505 Q86YH6 453 1.8e-43 Decaprenyl-diphosphate synthase subunit 2 OS=Homo sapiens GN=PDSS2 PE=1 SV=2 PF00348//PF04207 Polyprenyl synthetase//Tetrahydromethanopterin S-methyltransferase, subunit D GO:0006814//GO:0008299//GO:0046656 sodium ion transport//isoprenoid biosynthetic process//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0012506//GO:0005737 vesicle membrane//cytoplasm KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.24010 BF_2 4.03 2.11 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24012 BF_2 26.54 0.59 2161 270014464 EFA10912.1 1586 1.7e-173 hypothetical protein TcasGA2_TC001738 [Tribolium castaneum] 805771594 XM_012281304.1 194 1.39562e-94 PREDICTED: Megachile rotundata casein kinase I isoform gamma-3 (LOC100876501), transcript variant X5, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q62763 1366 2.3e-149 Casein kinase I isoform gamma-3 OS=Rattus norvegicus GN=Csnk1g3 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.24014 BF_2 6.98 0.44 946 589968018 XP_006996507.1 370 7.7e-33 PREDICTED: zinc finger protein 431-like [Peromyscus maniculatus bairdii] -- -- -- -- -- -- -- -- -- Q9UJN7 344 3.3e-31 Zinc finger protein 391 OS=Homo sapiens GN=ZNF391 PE=2 SV=2 PF02892//PF13912//PF01428//PF00096//PF13465 BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.24016 BF_2 832.50 21.42 1913 189242016 XP_001807518.1 1974 1.6e-218 PREDICTED: carboxypeptidase E-like [Tribolium castaneum] 37787288 AY214171.1 41 1.39038e-09 Paralichthys olivaceus carboxypeptidase H mRNA, complete cds K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P37892 1035 4.9e-111 Carboxypeptidase E OS=Lophius americanus GN=cpe PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0004181//GO:0016788//GO:0008270 metallocarboxypeptidase activity//hydrolase activity, acting on ester bonds//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.24018 BF_2 16.14 0.43 1860 559783744 AHB18586.1 999 1.7e-105 heat shock 60 kDa protein [Leptinotarsa decemlineata] 66270661 AE017282.2 53 2.88361e-16 Methylococcus capsulatus str. Bath, complete genome K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 O02649 889 4.1e-94 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3 PF00118//PF02912//PF02872 TCP-1/cpn60 chaperonin family//Aminoacyl tRNA synthetase class II, N-terminal domain//5'-nucleotidase, C-terminal domain GO:0006432//GO:0000162//GO:0006571//GO:0009166//GO:0009094 phenylalanyl-tRNA aminoacylation//tryptophan biosynthetic process//tyrosine biosynthetic process//nucleotide catabolic process//L-phenylalanine biosynthetic process GO:0004826//GO:0016787//GO:0005524//GO:0000166 phenylalanine-tRNA ligase activity//hydrolase activity//ATP binding//nucleotide binding GO:0005737//GO:0009328 cytoplasm//phenylalanine-tRNA ligase complex KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-8309.24020 BF_2 3.00 0.94 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24021 BF_2 5.90 2.50 384 642920120 XP_008192214.1 323 8.7e-28 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24023 BF_2 21.41 0.42 2444 91082195 XP_971684.1 344 2.0e-29 PREDICTED: nipped-B-like protein B [Tribolium castaneum]>gi|270007443|gb|EFA03891.1| hypothetical protein TcasGA2_TC014015 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T200 132 3.2e-06 Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens GN=ZC3H13 PE=1 SV=1 PF00642//PF08915 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Archaea-specific editing domain of threonyl-tRNA synthetase GO:0006566//GO:0006544//GO:0006435//GO:0006563 threonine metabolic process//glycine metabolic process//threonyl-tRNA aminoacylation//L-serine metabolic process GO:0003676//GO:0008270//GO:0046872//GO:0004829//GO:0005524 nucleic acid binding//zinc ion binding//metal ion binding//threonine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.24028 BF_2 993.00 6.98 6237 478257181 ENN77344.1 2459 3.0e-274 hypothetical protein YQE_06170, partial [Dendroctonus ponderosae]>gi|546681413|gb|ERL91510.1| hypothetical protein D910_08840 [Dendroctonus ponderosae] 471419251 XM_004391060.1 39 5.93403e-08 PREDICTED: Trichechus manatus latirostris F-box and WD repeat domain containing 5 (LOC101355169), mRNA K10263 FBXW5 F-box and WD-40 domain protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10263 Q9QXW2 1187 3.8e-128 F-box/WD repeat-containing protein 5 OS=Mus musculus GN=Fbxw5 PE=1 SV=1 PF12937//PF00355//PF00400//PF00646 F-box-like//Rieske [2Fe-2S] domain//WD domain, G-beta repeat//F-box domain GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0051537 oxidoreductase activity//protein binding//2 iron, 2 sulfur cluster binding -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.24030 BF_2 53.30 0.46 5186 642928597 XP_008199971.1 3871 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q96BY7 992 1.3e-105 Autophagy-related protein 2 homolog B OS=Homo sapiens GN=ATG2B PE=1 SV=5 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.24035 BF_2 48.73 1.50 1650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24036 BF_2 45.80 2.40 1087 91085455 XP_969485.1 169 1.8e-09 PREDICTED: WASH complex subunit FAM21A [Tribolium castaneum]>gi|270009171|gb|EFA05619.1| hypothetical protein TcasGA2_TC015827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05793 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0006367//GO:0032968 transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.24037 BF_2 394.18 1.63 10419 642932470 XP_008197129.1 572 3.2e-55 PREDICTED: uncharacterized protein YKL105C-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641Q2 235 1.6e-17 WASH complex subunit FAM21A OS=Homo sapiens GN=FAM21A PE=2 SV=3 PF02724//PF09726//PF04889//PF06003//PF05132 CDC45-like protein//Transmembrane protein//Cwf15/Cwc15 cell cycle control protein//Survival motor neuron protein (SMN)//RNA polymerase III RPC4 GO:0000398//GO:0006270//GO:0006206//GO:0006144//GO:0006351//GO:0006383//GO:0006397 mRNA splicing, via spliceosome//DNA replication initiation//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//mRNA processing GO:0003899//GO:0003723//GO:0003677 DNA-directed RNA polymerase activity//RNA binding//DNA binding GO:0005737//GO:0005666//GO:0005730//GO:0016021//GO:0005681//GO:0005634 cytoplasm//DNA-directed RNA polymerase III complex//nucleolus//integral component of membrane//spliceosomal complex//nucleus -- -- Cluster-8309.24039 BF_2 321.00 3.39 4251 91081221 XP_975624.1 731 4.8e-74 PREDICTED: serine/threonine/tyrosine-interacting protein [Tribolium castaneum]>gi|270005257|gb|EFA01705.1| hypothetical protein TcasGA2_TC007281 [Tribolium castaneum] -- -- -- -- -- K18042 STYX serine/threonine/tyrosine-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K18042 Q60969 401 3.6e-37 Serine/threonine/tyrosine-interacting protein OS=Mus musculus GN=Styx PE=1 SV=2 PF00102//PF06596//PF08782//PF09034//PF04179//PF00782 Protein-tyrosine phosphatase//Photosystem II reaction centre X protein (PsbX)//c-SKI Smad4 binding domain//TRADD, N-terminal domain//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain GO:0007165//GO:0019988//GO:0006570//GO:0016311//GO:0043123//GO:0015979//GO:0006470 signal transduction//charged-tRNA amino acid modification//tyrosine metabolic process//dephosphorylation//positive regulation of I-kappaB kinase/NF-kappaB signaling//photosynthesis//protein dephosphorylation GO:0043399//GO:0005515//GO:0008138//GO:0016791//GO:0004725//GO:0004871//GO:0046332 tRNA A64-2'-O-ribosylphosphate transferase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//phosphatase activity//protein tyrosine phosphatase activity//signal transducer activity//SMAD binding GO:0016020//GO:0009523 membrane//photosystem II KOG1716 Dual specificity phosphatase Cluster-8309.24040 BF_2 40.39 3.00 851 642914372 XP_008201652.1 231 9.0e-17 PREDICTED: uncharacterized protein LOC659966 [Tribolium castaneum]>gi|270001589|gb|EEZ98036.1| hypothetical protein TcasGA2_TC000438 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.24042 BF_2 19.91 0.32 2886 546678229 ERL88905.1 201 9.2e-13 hypothetical protein D910_06287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11081 Protein of unknown function (DUF2890) GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.24043 BF_2 180.41 1.90 4269 642934852 XP_008197837.1 4830 0.0e+00 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1907 8.5e-212 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF02985//PF00069//PF00400//PF07714 HEAT repeat//Protein kinase domain//WD domain, G-beta repeat//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.24044 BF_2 357.69 21.44 985 478257549 ENN77703.1 470 2.0e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 167 1.1e-10 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.24048 BF_2 130.21 3.36 1909 270010553 EFA07001.1 1061 1.2e-112 hypothetical protein TcasGA2_TC009970 [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q5VWX1 417 2.3e-39 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Homo sapiens GN=KHDRBS2 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.24051 BF_2 155.87 1.71 4102 91081353 XP_971021.1 1303 2.2e-140 PREDICTED: protein FAM114A2 [Tribolium castaneum]>gi|270005192|gb|EFA01640.1| hypothetical protein TcasGA2_TC007210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDV3 568 1.5e-56 Probable nucleoporin Nup58 OS=Drosophila melanogaster GN=Nup58 PE=2 SV=1 PF08515//PF14620//PF00435//PF04029 Transforming growth factor beta type I GS-motif//YpeB sporulation//Spectrin repeat//2-phosphosulpholactate phosphatase GO:0009847//GO:0006468//GO:0009069//GO:0016310//GO:0007178 spore germination//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0050532//GO:0000287//GO:0004675//GO:0005515//GO:0005524 2-phosphosulfolactate phosphatase activity//magnesium ion binding//transmembrane receptor protein serine/threonine kinase activity//protein binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.24052 BF_2 4.00 0.45 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24053 BF_2 20.75 0.64 1650 642933182 XP_008197293.1 1709 7.3e-188 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933184|ref|XP_008197294.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933186|ref|XP_008197295.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933188|ref|XP_008197296.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933190|ref|XP_008197297.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933192|ref|XP_008197298.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933194|ref|XP_008197299.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933196|ref|XP_008197300.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933198|ref|XP_008197301.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933200|ref|XP_008197302.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933202|ref|XP_008197305.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933204|ref|XP_008197306.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|642933206|ref|XP_008197307.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X4 [Tribolium castaneum]>gi|270012551|gb|EFA08999.1| hypothetical protein TcasGA2_TC006706 [Tribolium castaneum] 430763429 JQ753065.1 49 4.27006e-14 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 Q63511 896 5.6e-95 G protein-activated inward rectifier potassium channel 3 OS=Rattus norvegicus GN=Kcnj9 PE=1 SV=2 PF10716//PF01007//PF00520 NADH dehydrogenase transmembrane subunit//Inward rectifier potassium channel//Ion transport protein GO:0006118//GO:0055114//GO:0034765//GO:0006811//GO:0055085//GO:0006813 obsolete electron transport//oxidation-reduction process//regulation of ion transmembrane transport//ion transport//transmembrane transport//potassium ion transport GO:0005216//GO:0016655//GO:0005242 ion channel activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//inward rectifier potassium channel activity GO:0016020//GO:0008076//GO:0016021 membrane//voltage-gated potassium channel complex//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.24054 BF_2 14.00 0.58 1293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24055 BF_2 38.04 0.72 2494 637366323 XP_008121191.1 644 3.4e-64 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Anolis carolinensis] 195570403 XM_002103161.1 85 6.32019e-34 Drosophila simulans GD19093 (Dsim\GD19093), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 590 2.6e-59 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00096//PF13465//PF11615//PF07776//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Protein of unknown function (DUF3249)//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger GO:0000266 mitochondrial fission GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634//GO:0005739 nucleus//mitochondrion -- -- Cluster-8309.24058 BF_2 171.31 1.62 4709 642923667 XP_008193834.1 3845 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2245 6.0e-251 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03193//PF00005//PF06414//PF00437//PF00735//PF01926//PF13304//PF00664 Protein of unknown function, DUF258//ABC transporter//Zeta toxin//Type II/IV secretion system protein//Septin//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0016301//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24059 BF_2 495.93 4.76 4646 642923667 XP_008193834.1 3736 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91660 2275 2.0e-254 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF06414//PF00005//PF03193//PF00664//PF13304//PF01926//PF00735//PF00437 Zeta toxin//ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Septin//Type II/IV secretion system protein GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887//GO:0016301 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24060 BF_2 100.71 1.90 2505 189233588 XP_969590.2 995 6.8e-105 PREDICTED: palmitoyl-protein thioesterase 1 [Tribolium castaneum]>gi|270014931|gb|EFA11379.1| hypothetical protein TcasGA2_TC011538 [Tribolium castaneum] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 O88531 733 6.8e-76 Palmitoyl-protein thioesterase 1 OS=Mus musculus GN=Ppt1 PE=2 SV=2 PF01674//PF02089 Lipase (class 2)//Palmitoyl protein thioesterase GO:0006464 cellular protein modification process GO:0008474//GO:0016787//GO:0098599 palmitoyl-(protein) hydrolase activity//hydrolase activity//palmitoyl hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.24063 BF_2 195.00 6.28 1587 91079302 XP_966978.1 1460 5.2e-159 PREDICTED: serine/threonine-protein kinase RIO2 [Tribolium castaneum]>gi|270004321|gb|EFA00769.1| hypothetical protein TcasGA2_TC003655 [Tribolium castaneum] -- -- -- -- -- K07179 RIOK2 RIO kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07179 Q9CQS5 1100 1.2e-118 Serine/threonine-protein kinase RIO2 OS=Mus musculus GN=Riok2 PE=2 SV=1 PF09202//PF06293 Rio2, N-terminal//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0005524//GO:0004674 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein serine/threonine kinase activity GO:0016020 membrane KOG2268 Serine/threonine protein kinase Cluster-8309.24064 BF_2 292.62 4.07 3297 546676098 ERL87165.1 3546 0.0e+00 hypothetical protein D910_04565 [Dendroctonus ponderosae] -- -- -- -- -- K08675 PRSS15, PIM1 Lon-like ATP-dependent protease http://www.genome.jp/dbget-bin/www_bget?ko:K08675 P36776 2821 0.0e+00 Lon protease homolog, mitochondrial OS=Homo sapiens GN=LONP1 PE=1 SV=2 PF02367//PF03266//PF07726//PF03193//PF00005//PF02190//PF00931//PF00910//PF05496//PF07728//PF01695//PF07724//PF06309//PF05362//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//NTPase//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//ATP-dependent protease La (LON) substrate-binding domain//NB-ARC domain//RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//Torsin//Lon protease (S16) C-terminal proteolytic domain//ATPase family associated with various cellular activities (AAA) GO:0006510//GO:0006281//GO:0002949//GO:0006310//GO:0006508 obsolete ATP-dependent proteolysis//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis GO:0004252//GO:0004176//GO:0016887//GO:0003924//GO:0005524//GO:0098519//GO:0009378//GO:0003724//GO:0005525//GO:0043531//GO:0003723 serine-type endopeptidase activity//ATP-dependent peptidase activity//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//four-way junction helicase activity//RNA helicase activity//GTP binding//ADP binding//RNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG2004 Mitochondrial ATP-dependent protease PIM1/LON Cluster-8309.24065 BF_2 346.39 4.90 3247 91077206 XP_973021.1 3441 0.0e+00 PREDICTED: lon protease homolog, mitochondrial isoform X2 [Tribolium castaneum]>gi|270001698|gb|EEZ98145.1| hypothetical protein TcasGA2_TC000570 [Tribolium castaneum] -- -- -- -- -- K08675 PRSS15, PIM1 Lon-like ATP-dependent protease http://www.genome.jp/dbget-bin/www_bget?ko:K08675 Q924S5 2806 0.0e+00 Lon protease homolog, mitochondrial OS=Rattus norvegicus GN=Lonp1 PE=2 SV=1 PF00005//PF07726//PF03266//PF03193//PF00910//PF02190//PF01443//PF05496//PF07724//PF02367//PF00931//PF01695//PF07728//PF06309//PF00004//PF05362 ABC transporter//ATPase family associated with various cellular activities (AAA)//NTPase//Protein of unknown function, DUF258//RNA helicase//ATP-dependent protease La (LON) substrate-binding domain//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (Cdc48 subfamily)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Torsin//ATPase family associated with various cellular activities (AAA)//Lon protease (S16) C-terminal proteolytic domain GO:0002949//GO:0006310//GO:0006508//GO:0006281//GO:0006510 tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis//DNA repair//obsolete ATP-dependent proteolysis GO:0043531//GO:0003723//GO:0009378//GO:0003724//GO:0005525//GO:0003924//GO:0005524//GO:0098519//GO:0004252//GO:0004176//GO:0016887 ADP binding//RNA binding//four-way junction helicase activity//RNA helicase activity//GTP binding//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//serine-type endopeptidase activity//ATP-dependent peptidase activity//ATPase activity GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG2004 Mitochondrial ATP-dependent protease PIM1/LON Cluster-8309.24067 BF_2 211.20 7.14 1524 91079782 XP_967732.1 1443 4.7e-157 PREDICTED: 39S ribosomal protein L38, mitochondrial [Tribolium castaneum]>gi|270003311|gb|EEZ99758.1| hypothetical protein TcasGA2_TC002530 [Tribolium castaneum] 170048742 XM_001870724.1 54 6.54141e-17 Culex quinquefasciatus mitochondrial ribosomal protein L38, mRNA K17419 MRPL38 large subunit ribosomal protein L38 http://www.genome.jp/dbget-bin/www_bget?ko:K17419 Q3ZBF3 787 2.2e-82 39S ribosomal protein L38, mitochondrial OS=Bos taurus GN=MRPL38 PE=1 SV=2 PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.24068 BF_2 136.00 2.66 2423 91086035 XP_973305.1 1682 1.4e-184 PREDICTED: centromere/kinetochore protein zw10 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RFM4 796 3.2e-83 Centromere/kinetochore protein zw10 homolog OS=Pongo abelii GN=ZW10 PE=2 SV=3 PF05130//PF06248//PF00439 FlgN protein//Centromere/kinetochore Zw10//Bromodomain GO:0044780//GO:0007067 bacterial-type flagellum assembly//mitotic nuclear division GO:0005515 protein binding GO:0005634//GO:0000775 nucleus//chromosome, centromeric region KOG2163 Centromere/kinetochore protein zw10 involved in mitotic chromosome segregation Cluster-8309.24070 BF_2 86.81 1.45 2788 270003257 EEZ99704.1 685 6.7e-69 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q60HE9 463 1.5e-44 Lysosomal alpha-mannosidase OS=Macaca fascicularis GN=MAN2B1 PE=2 SV=1 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923 mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.24076 BF_2 9.00 1.86 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24082 BF_2 49.88 0.98 2413 642912148 XP_008200826.1 1569 1.8e-171 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 487 2.2e-47 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.24084 BF_2 6.00 0.38 946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24085 BF_2 3.00 0.34 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24087 BF_2 103.96 6.45 961 478255204 ENN75433.1 945 1.6e-99 hypothetical protein YQE_07984, partial [Dendroctonus ponderosae] -- -- -- -- -- K15447 TRM44, METTL19 tRNASer (uridine44-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15447 Q9VHB9 569 2.7e-57 Probable tRNA (uracil-O(2)-)-methyltransferase OS=Drosophila melanogaster GN=trmt44 PE=2 SV=2 PF01544//PF07757 CorA-like Mg2+ transporter protein//Predicted AdoMet-dependent methyltransferase GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873//GO:0008168 metal ion transmembrane transporter activity//methyltransferase activity GO:0016020 membrane KOG3790 Uncharacterized conserved protein Cluster-8309.24088 BF_2 95.36 4.51 1171 189241264 XP_974292.2 754 2.8e-77 PREDICTED: probable tRNA (uracil-O(2)-)-methyltransferase [Tribolium castaneum]>gi|642936064|ref|XP_008198287.1| PREDICTED: probable tRNA (uracil-O(2)-)-methyltransferase [Tribolium castaneum]>gi|270013210|gb|EFA09658.1| hypothetical protein TcasGA2_TC011784 [Tribolium castaneum] -- -- -- -- -- K15447 TRM44, METTL19 tRNASer (uridine44-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15447 Q4KLT3 243 2.1e-19 Probable tRNA (uracil-O(2)-)-methyltransferase OS=Xenopus laevis GN=trmt44 PE=2 SV=1 PF07757 Predicted AdoMet-dependent methyltransferase -- -- GO:0008168 methyltransferase activity -- -- KOG3790 Uncharacterized conserved protein Cluster-8309.24091 BF_2 35.69 0.49 3343 642927688 XP_008196543.1 663 2.9e-66 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 1.6e-27 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF13855//PF00128 Leucine rich repeat//Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824//GO:0005515 cation binding//catalytic activity//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.24096 BF_2 208.00 8.11 1360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11057 Cortexin of kidney -- -- -- -- GO:0031224 intrinsic component of membrane -- -- Cluster-8309.24098 BF_2 22.68 0.31 3336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2410 BF_2 11.00 0.40 1430 270015520 EFA11968.1 335 1.3e-28 hypothetical protein TcasGA2_TC004049 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05870//PF08219//PF01355//PF00665//PF05038 Phenolic acid decarboxylase (PAD)//Outer membrane protein TOM13//High potential iron-sulfur protein//Integrase core domain//Cytochrome Cytochrome b558 alpha-subunit GO:0006118//GO:0019646//GO:0015074 obsolete electron transport//aerobic electron transport chain//DNA integration GO:0009055//GO:0016831//GO:0020037 electron carrier activity//carboxy-lyase activity//heme binding GO:0005741 mitochondrial outer membrane -- -- Cluster-8309.24100 BF_2 37.44 0.89 2039 642933664 XP_008197512.1 883 5.4e-92 PREDICTED: bifunctional coenzyme A synthase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K02318 COASY phosphopantetheine adenylyltransferase / dephospho-CoA kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02318 Q8MIR4 528 3.2e-52 Bifunctional coenzyme A synthase OS=Sus scrofa GN=COASY PE=1 SV=1 PF01467//PF03861//PF01121 Cytidylyltransferase-like//ANTAR domain//Dephospho-CoA kinase GO:0015940//GO:0009058//GO:0015937 pantothenate biosynthetic process//biosynthetic process//coenzyme A biosynthetic process GO:0003723//GO:0003824//GO:0005524//GO:0004140 RNA binding//catalytic activity//ATP binding//dephospho-CoA kinase activity -- -- KOG3351 Predicted nucleotidyltransferase Cluster-8309.24101 BF_2 37.12 0.44 3845 189240717 XP_974290.2 881 1.7e-91 PREDICTED: polycomb group protein Pc isoform X3 [Tribolium castaneum]>gi|270014283|gb|EFA10731.1| polycomb [Tribolium castaneum] -- -- -- -- -- K11454 CBX7 chromobox protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11454 P26017 232 1.3e-17 Polycomb group protein Pc OS=Drosophila melanogaster GN=Pc PE=1 SV=1 PF00437 Type II/IV secretion system protein GO:0006810 transport GO:0005524 ATP binding -- -- KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.24102 BF_2 61.63 0.81 3465 642926801 XP_969339.3 2072 1.2e-229 PREDICTED: histone-lysine N-methyltransferase SETD1B [Tribolium castaneum] 768423227 XM_011554208.1 242 4.66856e-121 PREDICTED: Plutella xylostella histone-lysine N-methyltransferase SETD1-like (LOC105384048), mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 1105 6.8e-119 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856//PF03490 SET domain//Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0005515//GO:0047396 protein binding//glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.24103 BF_2 12.00 1.74 576 478257476 ENN77632.1 238 9.4e-18 hypothetical protein YQE_05926, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24104 BF_2 899.44 9.37 4302 91093869 XP_967782.1 6308 0.0e+00 PREDICTED: cytoplasmic FMR1-interacting protein [Tribolium castaneum]>gi|270014526|gb|EFA10974.1| hypothetical protein TcasGA2_TC004140 [Tribolium castaneum] 572271770 XM_006613756.1 1177 0 PREDICTED: Apis dorsata cytoplasmic FMR1-interacting protein-like (LOC102675501), mRNA K05749 CYFIP cytoplasmic FMR1 interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05749 Q9VF87 5574 0.0e+00 Cytoplasmic FMR1-interacting protein OS=Drosophila melanogaster GN=Sra-1 PE=1 SV=1 -- -- -- -- -- -- GO:0005737 cytoplasm KOG3534 p53 inducible protein PIR121 Cluster-8309.24105 BF_2 623.03 6.42 4344 642936074 XP_008198292.1 3618 0.0e+00 PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum]>gi|642936076|ref|XP_008198293.1| PREDICTED: telomerase-binding protein EST1A [Tribolium castaneum] 617356403 XM_007554354.1 36 1.91894e-06 PREDICTED: Poecilia formosa SMG6 nonsense mediated mRNA decay factor (smg6), transcript variant X2, mRNA K11124 SMG6, EST1A protein SMG6 http://www.genome.jp/dbget-bin/www_bget?ko:K11124 Q5RAK6 1366 4.7e-149 Telomerase-binding protein EST1A OS=Pongo abelii GN=SMG6 PE=2 SV=1 PF01805//PF00282 Surp module//Pyridoxal-dependent decarboxylase conserved domain GO:0019752//GO:0006396 carboxylic acid metabolic process//RNA processing GO:0030170//GO:0016831//GO:0003723 pyridoxal phosphate binding//carboxy-lyase activity//RNA binding -- -- KOG2162 Nonsense-mediated mRNA decay protein Cluster-8309.2411 BF_2 12.00 0.83 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24111 BF_2 347.00 10.83 1627 642920461 XP_008192360.1 249 1.4e-18 PREDICTED: CREB-binding protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24114 BF_2 3.00 0.53 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24116 BF_2 25.02 0.34 3344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24120 BF_2 31.41 2.04 931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24122 BF_2 75.50 0.40 8121 478251011 ENN71492.1 1218 3.1e-130 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q91YE3 670 4.4e-68 Egl nine homolog 1 OS=Mus musculus GN=Egln1 PE=2 SV=2 PF01254//PF13640//PF03117 Nuclear transition protein 2//2OG-Fe(II) oxygenase superfamily//UL49 family GO:0016032//GO:0007283//GO:0055114 viral process//spermatogenesis//oxidation-reduction process GO:0003677//GO:0016491 DNA binding//oxidoreductase activity GO:0000786//GO:0005634//GO:0019033 nucleosome//nucleus//viral tegument KOG3710 EGL-Nine (EGLN) protein Cluster-8309.24126 BF_2 501.47 2.92 7473 546683888 ERL93636.1 918 1.7e-95 hypothetical protein D910_10924 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NZM4 177 6.0e-11 Glioma tumor suppressor candidate region gene 1 protein OS=Homo sapiens GN=GLTSCR1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24128 BF_2 368.16 12.80 1490 91077766 XP_968426.1 1334 2.0e-144 PREDICTED: WD repeat domain phosphoinositide-interacting protein 4 [Tribolium castaneum]>gi|270002238|gb|EEZ98685.1| hypothetical protein TcasGA2_TC001220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCV0 1088 2.7e-117 WD repeat domain phosphoinositide-interacting protein 4 OS=Xenopus laevis GN=wdr45 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0005634 nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.24129 BF_2 9.00 0.36 1322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2413 BF_2 1.00 0.85 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24130 BF_2 4.84 0.42 767 91089745 XP_975162.1 391 2.3e-35 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q1RMT7 308 3.9e-27 Serine/threonine-protein kinase RIO3 OS=Bos taurus GN=RIOK3 PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.24134 BF_2 146.53 4.86 1549 668447779 KFB37519.1 608 3.2e-60 AGAP011148-PA-like protein [Anopheles sinensis] 645021074 XM_008209220.1 57 1.42959e-18 PREDICTED: Nasonia vitripennis 39S ribosomal protein L14, mitochondrial (LOC100115115), transcript variant X3, mRNA K11188 PRDX6 peroxiredoxin 6, 1-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11188 O08709 435 1.5e-41 Peroxiredoxin-6 OS=Mus musculus GN=Prdx6 PE=1 SV=3 PF00238//PF08534//PF00578 Ribosomal protein L14p/L23e//Redoxin//AhpC/TSA family GO:0006412//GO:0042254//GO:0055114 translation//ribosome biogenesis//oxidation-reduction process GO:0016209//GO:0003735//GO:0016491 antioxidant activity//structural constituent of ribosome//oxidoreductase activity GO:0005840 ribosome KOG0854 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.24135 BF_2 35.33 0.66 2530 134131322 BAF49604.1 1050 2.9e-111 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 531 1.8e-52 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF00089 Glycosyl hydrolases family 18//Trypsin GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0004553 serine-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.24137 BF_2 8.55 0.33 1379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24138 BF_2 20.62 0.65 1624 123482337 XP_001323756.1 242 9.1e-18 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q9EP71 189 5.3e-13 Ankycorbin OS=Mus musculus GN=Rai14 PE=1 SV=1 PF13606//PF00340//PF00023 Ankyrin repeat//Interleukin-1 / 18//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005615 extracellular space KOG4177 Ankyrin Cluster-8309.24139 BF_2 15.85 0.62 1356 546684831 ERL94413.1 492 7.8e-47 hypothetical protein D910_11691 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P10746 248 6.3e-20 Uroporphyrinogen-III synthase OS=Homo sapiens GN=UROS PE=1 SV=1 PF02602 Uroporphyrinogen-III synthase HemD GO:0006783//GO:0033014//GO:0015994 heme biosynthetic process//tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0004852 uroporphyrinogen-III synthase activity -- -- -- -- Cluster-8309.24142 BF_2 22.46 0.34 3019 91080721 XP_975378.1 1530 7.6e-167 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005867|gb|EFA02315.1| hypothetical protein TcasGA2_TC007981 [Tribolium castaneum] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 Q5VXJ0 718 4.5e-74 Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2 PF08168//PF08241//PF01738//PF04083 NUC205 domain//Methyltransferase domain//Dienelactone hydrolase family//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0016042//GO:0008152 lipid metabolic process//lipid catabolic process//metabolic process GO:0016787//GO:0016788//GO:0008168 hydrolase activity//hydrolase activity, acting on ester bonds//methyltransferase activity GO:0005634 nucleus KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.24144 BF_2 13.00 0.41 1625 241780604 XP_002400201.1 633 4.2e-63 E3 ubiquitin ligase, putative [Ixodes scapularis]>gi|215510686|gb|EEC20139.1| E3 ubiquitin ligase, putative [Ixodes scapularis] -- -- -- -- -- K09250 CNBP cellular nucleic acid-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09250 Q04832 426 1.7e-40 DNA-binding protein HEXBP OS=Leishmania major GN=HEXBP PE=3 SV=1 PF04565//PF00098 RNA polymerase Rpb2, domain 3//Zinc knuckle GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0008270//GO:0043169//GO:0003676//GO:0003899//GO:0003824//GO:0003677 zinc ion binding//cation binding//nucleic acid binding//DNA-directed RNA polymerase activity//catalytic activity//DNA binding GO:0005730 nucleolus KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.24146 BF_2 296.77 3.63 3709 478250611 ENN71103.1 1166 1.5e-124 hypothetical protein YQE_12036, partial [Dendroctonus ponderosae]>gi|546673105|gb|ERL84774.1| hypothetical protein D910_02199 [Dendroctonus ponderosae] -- -- -- -- -- K12195 CHMP6, VPS20 charged multivesicular body protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12195 O18391 805 4.5e-84 Probable serine hydrolase OS=Drosophila melanogaster GN=kraken PE=2 SV=1 PF01674//PF00975//PF01764//PF01063//PF03357//PF07819 Lipase (class 2)//Thioesterase domain//Lipase (class 3)//Amino-transferase class IV//Snf7//PGAP1-like protein GO:0006505//GO:0008152//GO:0006629//GO:0006886//GO:0007034//GO:0009058 GPI anchor metabolic process//metabolic process//lipid metabolic process//intracellular protein transport//vacuolar transport//biosynthetic process GO:0003824//GO:0016788//GO:0016787 catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- -- -- Cluster-8309.24149 BF_2 55.12 1.06 2453 332374680 AEE62481.1 1921 2.8e-212 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 P83740 1379 8.2e-151 Putative sodium-dependent multivitamin transporter OS=Drosophila melanogaster GN=CG32669 PE=2 SV=1 PF01781//PF00474 Ribosomal L38e protein family//Sodium:solute symporter family GO:0042254//GO:0006810//GO:0006412//GO:0055085 ribosome biogenesis//transport//translation//transmembrane transport GO:0003735//GO:0005215 structural constituent of ribosome//transporter activity GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular -- -- Cluster-8309.24150 BF_2 103.03 0.33 13273 642930187 XP_008196292.1 2642 3.8e-295 PREDICTED: spatacsin [Tribolium castaneum]>gi|270009457|gb|EFA05905.1| hypothetical protein TcasGA2_TC008718 [Tribolium castaneum] 195121589 XM_002005267.1 94 3.37585e-38 Drosophila mojavensis GI20407 (Dmoj\GI20407), mRNA K07832 RIT1 Ras-like without CAAX 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07832 P70426 634 1.1e-63 GTP-binding protein Rit1 OS=Mus musculus GN=Rit1 PE=1 SV=1 PF08533//PF00025//PF03015//PF01979//PF08477//PF00071//PF03193//PF00962//PF02459 Beta-galactosidase C-terminal domain//ADP-ribosylation factor family//Male sterility protein//Amidohydrolase family//Ras of Complex, Roc, domain of DAPkinase//Ras family//Protein of unknown function, DUF258//Adenosine/AMP deaminase//Adenoviral DNA terminal protein GO:0006260//GO:0046486//GO:0006687//GO:0007264//GO:0006012//GO:0006027 DNA replication//glycerolipid metabolic process//glycosphingolipid metabolic process//small GTPase mediated signal transduction//galactose metabolic process//glycosaminoglycan catabolic process GO:0080019//GO:0005525//GO:0016787//GO:0004565//GO:0003677//GO:0003924//GO:0019239 fatty-acyl-CoA reductase (alcohol-forming) activity//GTP binding//hydrolase activity//beta-galactosidase activity//DNA binding//GTPase activity//deaminase activity GO:0009341 beta-galactosidase complex KOG0395 Ras-related GTPase Cluster-8309.24151 BF_2 45.44 1.34 1707 94469232 ABF18465.1 458 8.7e-43 hypothetical protein [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24153 BF_2 203.00 1.81 4977 91082041 XP_970854.1 1810 4.2e-199 PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|642921977|ref|XP_008192967.1| PREDICTED: transcriptional regulator CRZ1 [Tribolium castaneum]>gi|270007300|gb|EFA03748.1| hypothetical protein TcasGA2_TC013857 [Tribolium castaneum] -- -- -- -- -- K10519 ZBTB48, HKR3 zinc finger and BTB domain-containing protein 48 http://www.genome.jp/dbget-bin/www_bget?ko:K10519 Q5R4K8 177 4.0e-11 Zinc finger protein 615 OS=Pongo abelii GN=ZNF615 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.24157 BF_2 359.00 12.71 1469 642934522 XP_001812598.2 826 1.6e-85 PREDICTED: O-acetyl-ADP-ribose deacetylase MACROD2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PAV8 609 9.5e-62 O-acetyl-ADP-ribose deacetylase MACROD2 OS=Xenopus laevis GN=macrod2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.24158 BF_2 2.00 0.42 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2416 BF_2 8.00 0.42 1081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24160 BF_2 165.00 3.49 2265 91092880 XP_970276.1 1691 1.2e-185 PREDICTED: glucose-fructose oxidoreductase domain-containing protein 2 [Tribolium castaneum]>gi|270003088|gb|EEZ99535.1| hypothetical protein TcasGA2_TC000117 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3B7J2 877 1.2e-92 Glucose-fructose oxidoreductase domain-containing protein 2 OS=Homo sapiens GN=GFOD2 PE=2 SV=1 PF03447//PF01408 Homoserine dehydrogenase, NAD binding domain//Oxidoreductase family, NAD-binding Rossmann fold GO:0055114 oxidation-reduction process GO:0016491//GO:0000166//GO:0050661 oxidoreductase activity//nucleotide binding//NADP binding -- -- KOG2742 Predicted oxidoreductase Cluster-8309.24162 BF_2 107.75 1.14 4230 478255350 ENN75576.1 1484 2.3e-161 hypothetical protein YQE_07919, partial [Dendroctonus ponderosae] -- -- -- -- -- K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q9VSD7 1226 7.8e-133 Lariat debranching enzyme OS=Drosophila melanogaster GN=ldbr PE=1 SV=1 PF00149//PF05011//PF01507 Calcineurin-like phosphoesterase//Lariat debranching enzyme, C-terminal domain//Phosphoadenosine phosphosulfate reductase family GO:0006397//GO:0008152 mRNA processing//metabolic process GO:0016787//GO:0016788//GO:0003824 hydrolase activity//hydrolase activity, acting on ester bonds//catalytic activity -- -- KOG2863 RNA lariat debranching enzyme Cluster-8309.24165 BF_2 126.20 8.16 934 642936409 XP_008198421.1 466 5.6e-44 PREDICTED: APOPT family protein CG14806, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q148E1 284 2.9e-24 Apoptogenic protein 1, mitochondrial OS=Bos taurus GN=APOPT1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4094 Uncharacterized conserved protein Cluster-8309.24171 BF_2 17.00 1.20 881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13762 Mitochondrial splicing apparatus component GO:0000372 Group I intron splicing -- -- GO:0030529 intracellular ribonucleoprotein complex -- -- Cluster-8309.24172 BF_2 130.42 4.58 1478 91087441 XP_975685.1 259 8.9e-20 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27018 161 8.5e-10 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF16049//PF01395 Frog antimicrobial peptide//PBP/GOBP family GO:0006952 defense response GO:0005549 odorant binding GO:0005576 extracellular region -- -- Cluster-8309.2418 BF_2 2.00 0.35 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24182 BF_2 176.41 9.75 1044 91085093 XP_967751.1 626 1.7e-62 PREDICTED: uridine diphosphate glucose pyrophosphatase [Tribolium castaneum]>gi|270008500|gb|EFA04948.1| hypothetical protein TcasGA2_TC015015 [Tribolium castaneum] -- -- -- -- -- K08077 NUDT14 UDP-sugar diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K08077 Q05B60 266 4.0e-22 Uridine diphosphate glucose pyrophosphatase OS=Bos taurus GN=NUDT14 PE=2 SV=1 PF09008//PF00293 Head binding//NUDIX domain GO:0009405 pathogenesis GO:0016787 hydrolase activity -- -- KOG4432 Uncharacterized NUDIX family hydrolase Cluster-8309.24183 BF_2 428.57 1.61 11454 642933099 XP_973043.3 3576 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.4e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF08587//PF14572//PF00076 Phosphoribosyl transferase domain//Ubiquitin associated domain (UBA)//Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006098//GO:0009069//GO:0006144//GO:0009165//GO:0016310//GO:0009116 pentose-phosphate shunt//serine family amino acid metabolic process//purine nucleobase metabolic process//nucleotide biosynthetic process//phosphorylation//nucleoside metabolic process GO:0003676//GO:0004749//GO:0000287//GO:0004674 nucleic acid binding//ribose phosphate diphosphokinase activity//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.24185 BF_2 39.00 2.57 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24187 BF_2 7.00 0.68 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24191 BF_2 368.00 4.25 3913 478257482 ENN77638.1 992 2.4e-104 hypothetical protein YQE_05932, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q29116 187 2.2e-12 Tenascin OS=Sus scrofa GN=TNC PE=1 SV=1 PF00731 AIR carboxylase GO:0006189 'de novo' IMP biosynthetic process -- -- -- -- -- -- Cluster-8309.24192 BF_2 229.66 8.05 1481 642911532 XP_008199462.1 1573 3.8e-172 PREDICTED: protein eva-1 homolog C isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58659 355 2.7e-32 Protein eva-1 homolog C OS=Mus musculus GN=Eva1c PE=2 SV=2 PF02140 Galactose binding lectin domain -- -- GO:0030246 carbohydrate binding -- -- KOG4729 Galactoside-binding lectin Cluster-8309.24194 BF_2 221.74 2.76 3643 189234810 XP_969391.2 1486 1.2e-161 PREDICTED: monocarboxylate transporter 10 [Tribolium castaneum] -- -- -- -- -- K08187 SLC16A10 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K08187 Q91Y77 932 8.3e-99 Monocarboxylate transporter 10 OS=Rattus norvegicus GN=Slc16a10 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.24195 BF_2 125.00 3.19 1927 642931695 XP_008196691.1 404 1.8e-36 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24201 BF_2 579.02 16.38 1766 642914906 XP_008190438.1 1619 2.1e-177 PREDICTED: cytochrome c oxidase assembly protein COX15 homolog [Tribolium castaneum]>gi|642914908|ref|XP_971726.3| PREDICTED: cytochrome c oxidase assembly protein COX15 homolog [Tribolium castaneum]>gi|270001402|gb|EEZ97849.1| hypothetical protein TcasGA2_TC000219 [Tribolium castaneum] 768916438 XR_964517.1 62 2.7158e-21 PREDICTED: Takifugu rubripes cytochrome c oxidase assembly protein COX15 homolog (LOC101068591), transcript variant X2, misc_RNA K02259 COX15 cytochrome c oxidase assembly protein subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K02259 Q8BJ03 1028 3.0e-110 Cytochrome c oxidase assembly protein COX15 homolog OS=Mus musculus GN=Cox15 PE=2 SV=1 PF02628//PF00944 Cytochrome oxidase assembly protein//Alphavirus core protein GO:0006508//GO:0006784//GO:0055114 proteolysis//heme a biosynthetic process//oxidation-reduction process GO:0016627//GO:0004252 oxidoreductase activity, acting on the CH-CH group of donors//serine-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2725 Cytochrome oxidase assembly factor COX15 Cluster-8309.24203 BF_2 656.71 39.59 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24206 BF_2 108.00 3.45 1597 546682882 ERL92768.1 424 7.1e-39 hypothetical protein D910_10076 [Dendroctonus ponderosae] -- -- -- -- -- K18710 SLBP histone RNA hairpin-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K18710 Q9VAN6 266 6.1e-22 Histone RNA hairpin-binding protein OS=Drosophila melanogaster GN=Slbp PE=1 SV=1 PF15247 Histone RNA hairpin-binding protein RNA-binding domain -- -- GO:0003723 RNA binding -- -- KOG3934 Histone mRNA stem-loop binding protein Cluster-8309.24208 BF_2 133.00 2.74 2315 226968621 YP_002808570.1 1527 1.3e-166 NADH dehydrogenase subunit 4 [Scylla paramamosain]>gi|225697857|gb|ACO07224.1| NADH dehydrogenase subunit 4 [Scylla paramamosain]>gi|403311096|gb|AFR34055.1| NADH dehydrogenase subunit 4 (mitochondrion) [Scylla paramamosain] 225697849 FJ827761.1 2315 0 Scylla paramamosain mitochondrion, complete genome K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P07707 884 1.9e-93 NADH-ubiquinone oxidoreductase chain 4 OS=Drosophila yakuba GN=mt:ND4 PE=3 SV=1 PF00420 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GO:0042773//GO:0055114 ATP synthesis coupled electron transport//oxidation-reduction process GO:0016491//GO:0016651 oxidoreductase activity//oxidoreductase activity, acting on NAD(P)H GO:0044425//GO:0005739 membrane part//mitochondrion KOG4845 NADH dehydrogenase, subunit 4 Cluster-8309.24209 BF_2 3.00 0.48 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24210 BF_2 25.00 3.61 577 356483027 CCE46016.1 681 4.0e-69 putative 40S ribosomal protein S12 [Nephrops norvegicus] 356483026 HE608882.1 285 9.23677e-146 Nephrops norvegicus mRNA for putative 40S ribosomal protein S12 (rpS12 gene) K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P84175 511 8.5e-51 40S ribosomal protein S12 OS=Gallus gallus GN=RPS12 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.24212 BF_2 31.65 0.58 2587 260799997 XP_002594923.1 439 2.1e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- O62836 323 2.4e-28 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF02150//PF00096//PF13465//PF07649 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain GO:0006351//GO:0006144//GO:0006206//GO:0055114 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0003899//GO:0003677//GO:0046872//GO:0047134 DNA-directed RNA polymerase activity//DNA binding//metal ion binding//protein-disulfide reductase activity GO:0005730 nucleolus -- -- Cluster-8309.24213 BF_2 52.36 1.01 2447 260799997 XP_002594923.1 439 2.0e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17010 323 2.3e-28 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF02150//PF00096//PF13465//PF07649 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain GO:0055114//GO:0006206//GO:0006144//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0047134//GO:0003677//GO:0003899 metal ion binding//protein-disulfide reductase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.24215 BF_2 4.00 0.36 752 390470016 XP_003734218.1 860 9.2e-90 PREDICTED: 40S ribosomal protein S3 [Callithrix jacchus] 677995389 XM_009077871.1 94 1.83299e-39 PREDICTED: Acanthisitta chloris ribosomal protein S3 (RPS3), mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 Q0Z8U2 858 6.5e-91 40S ribosomal protein S3 OS=Sus scrofa GN=RPS3 PE=1 SV=1 PF07650 KH domain -- -- GO:0003723 RNA binding -- -- KOG3181 40S ribosomal protein S3 Cluster-8309.24216 BF_2 42.27 0.78 2552 546677972 ERL88701.1 1744 9.8e-192 hypothetical protein D910_06083 [Dendroctonus ponderosae] 768424815 XM_011555075.1 112 6.33341e-49 PREDICTED: Plutella xylostella cytoplasmic protein NCK2 (LOC105384796), mRNA K07365 NCK NCK adaptor protein http://www.genome.jp/dbget-bin/www_bget?ko:K07365 P16333 853 8.4e-90 Cytoplasmic protein NCK1 OS=Homo sapiens GN=NCK1 PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains Cluster-8309.24217 BF_2 625.73 10.85 2700 189237088 XP_969702.2 1855 1.4e-204 PREDICTED: cytoplasmic protein NCK1 isoform X2 [Tribolium castaneum] 768424815 XM_011555075.1 112 6.70119e-49 PREDICTED: Plutella xylostella cytoplasmic protein NCK2 (LOC105384796), mRNA K07365 NCK NCK adaptor protein http://www.genome.jp/dbget-bin/www_bget?ko:K07365 P16333 853 8.9e-90 Cytoplasmic protein NCK1 OS=Homo sapiens GN=NCK1 PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4226 Adaptor protein NCK/Dock, contains SH2 and SH3 domains Cluster-8309.24218 BF_2 34.00 3.40 705 642928694 XP_008199741.1 207 4.5e-14 PREDICTED: microtubule-actin cross-linking factor 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24222 BF_2 3.00 0.43 576 478259891 ENN79701.1 213 7.5e-15 hypothetical protein YQE_03854, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q10258 138 1.5e-07 Methylenetetrahydrofolate reductase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=met9 PE=1 SV=1 PF02219 Methylenetetrahydrofolate reductase GO:0046653//GO:0006555//GO:0055114 tetrahydrofolate metabolic process//methionine metabolic process//oxidation-reduction process GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity -- -- KOG0564 5,10-methylenetetrahydrofolate reductase Cluster-8309.24223 BF_2 4.00 0.77 504 478259891 ENN79701.1 136 5.5e-06 hypothetical protein YQE_03854, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02219 Methylenetetrahydrofolate reductase GO:0055114//GO:0006555//GO:0046653 oxidation-reduction process//methionine metabolic process//tetrahydrofolate metabolic process GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity -- -- -- -- Cluster-8309.24224 BF_2 218.00 3.10 3228 546674737 ERL86046.1 987 7.5e-104 hypothetical protein D910_03460 [Dendroctonus ponderosae] -- -- -- -- -- K09572 FKBP6 FK506-binding protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09572 Q9W1I9 409 3.2e-38 Inactive peptidyl-prolyl cis-trans isomerase shutdown OS=Drosophila melanogaster GN=shu PE=1 SV=1 PF13414//PF00254 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.24225 BF_2 1.00 1.63 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24229 BF_2 40.16 0.65 2876 190702371 ACE75264.1 1977 1.1e-218 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24230 BF_2 67.86 0.53 5610 815769669 XP_012234959.1 1559 6.1e-170 PREDICTED: uncharacterized protein LOC105679478 [Linepithema humile] -- -- -- -- -- -- -- -- -- P34457 321 9.0e-28 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00503//PF02888//PF01580//PF13683//PF08398//PF00665 G-protein alpha subunit//Calmodulin binding domain//FtsK/SpoIIIE family//Integrase core domain//Parvovirus coat protein VP1//Integrase core domain GO:0006813//GO:0015074//GO:0007165//GO:0007186 potassium ion transport//DNA integration//signal transduction//G-protein coupled receptor signaling pathway GO:0003677//GO:0004871//GO:0005516//GO:0005524//GO:0031683//GO:0005198//GO:0003924//GO:0015269//GO:0000166//GO:0019001 DNA binding//signal transducer activity//calmodulin binding//ATP binding//G-protein beta/gamma-subunit complex binding//structural molecule activity//GTPase activity//calcium-activated potassium channel activity//nucleotide binding//guanyl nucleotide binding GO:0016021//GO:0019028 integral component of membrane//viral capsid -- -- Cluster-8309.24231 BF_2 4.00 2.89 339 780642694 XP_011688399.1 203 6.3e-14 PREDICTED: uncharacterized protein LOC105450313 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24232 BF_2 33.65 0.54 2883 190702371 ACE75264.1 1967 1.5e-217 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.24235 BF_2 1.00 1.91 287 607355635 EZA50197.1 133 7.0e-06 hypothetical protein X777_11336 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24236 BF_2 107.15 0.45 10283 759070124 XP_011344632.1 2644 1.7e-295 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08398//PF01637//PF13912//PF00910//PF02913 Parvovirus coat protein VP1//Archaeal ATPase//C2H2-type zinc finger//RNA helicase//FAD linked oxidases, C-terminal domain -- -- GO:0003724//GO:0046872//GO:0050660//GO:0005198//GO:0003824//GO:0005524//GO:0003723 RNA helicase activity//metal ion binding//flavin adenine dinucleotide binding//structural molecule activity//catalytic activity//ATP binding//RNA binding GO:0019028 viral capsid -- -- Cluster-8309.24237 BF_2 4.00 0.98 458 815765017 XP_012214528.1 528 1.8e-51 PREDICTED: uncharacterized protein LOC105667333, partial [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.24239 BF_2 241.85 1.02 10233 759070124 XP_011344632.1 2644 1.7e-295 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00910//PF02913//PF01637//PF13912//PF08398 RNA helicase//FAD linked oxidases, C-terminal domain//Archaeal ATPase//C2H2-type zinc finger//Parvovirus coat protein VP1 -- -- GO:0050660//GO:0046872//GO:0003724//GO:0005524//GO:0003824//GO:0003723//GO:0005198 flavin adenine dinucleotide binding//metal ion binding//RNA helicase activity//ATP binding//catalytic activity//RNA binding//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.24243 BF_2 1.23 0.44 403 478256356 ENN76546.1 245 1.0e-18 hypothetical protein YQE_06997, partial [Dendroctonus ponderosae]>gi|546680785|gb|ERL90991.1| hypothetical protein D910_08333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P17789 160 3.0e-10 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24244 BF_2 232.58 3.62 2973 642923235 XP_008193669.1 421 2.9e-38 PREDICTED: folliculin-interacting protein 1 [Tribolium castaneum]>gi|270007081|gb|EFA03529.1| hypothetical protein TcasGA2_TC013532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80TD3 192 4.3e-13 Folliculin-interacting protein 2 OS=Mus musculus GN=Fnip2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24245 BF_2 49.28 1.33 1834 675366016 KFM58918.1 273 2.6e-21 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24247 BF_2 154.01 2.83 2563 542218021 XP_005449110.1 167 7.2e-09 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like [Oreochromis niloticus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07710 P53 tetramerisation motif GO:0051262 protein tetramerization -- -- -- -- -- -- Cluster-8309.24248 BF_2 24.90 0.40 2911 542218021 XP_005449110.1 167 8.2e-09 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like [Oreochromis niloticus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03502 Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279 cell outer membrane -- -- Cluster-8309.24249 BF_2 7.50 0.32 1273 675366016 KFM58918.1 246 2.5e-18 Histone-lysine N-methyltransferase SETMAR, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24252 BF_2 165.00 5.39 1568 642926562 XP_008194921.1 614 6.5e-61 PREDICTED: fasciclin-1-like [Tribolium castaneum]>gi|270009110|gb|EFA05558.1| hypothetical protein TcasGA2_TC015746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 347 2.4e-31 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24254 BF_2 7.00 0.41 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24256 BF_2 26.33 0.85 1578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24260 BF_2 314.02 15.48 1136 270010525 EFA06973.1 213 1.5e-14 hypothetical protein TcasGA2_TC009933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24261 BF_2 36.00 1.06 1708 91079871 XP_967413.1 2343 2.3e-261 PREDICTED: tryptophan 5-hydroxylase 1 [Tribolium castaneum]>gi|270004554|gb|EFA01002.1| hypothetical protein TcasGA2_TC003915 [Tribolium castaneum] -- -- -- -- -- K00502 TPH1_2 tryptophan 5-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00502 P70080 1445 1.3e-158 Tryptophan 5-hydroxylase 1 OS=Gallus gallus GN=TPH1 PE=1 SV=1 PF01842//PF00351 ACT domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0055114//GO:0006568//GO:0009072//GO:0042427//GO:0008152 oxidation-reduction process//tryptophan metabolic process//aromatic amino acid family metabolic process//serotonin biosynthetic process//metabolic process GO:0005506//GO:0004510//GO:0016597//GO:0016714 iron ion binding//tryptophan 5-monooxygenase activity//amino acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.24263 BF_2 27.14 1.32 1145 270013391 EFA09839.1 1829 6.1e-202 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 199 1.21219e-97 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P0C6B8 206 4.0e-15 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.24265 BF_2 765.00 3.62 9117 642915919 XP_008190810.1 5228 0.0e+00 PREDICTED: protein retinal degeneration B isoform X2 [Tribolium castaneum] 642915918 XM_008192588.1 901 0 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X4, mRNA -- -- -- -- P43125 3836 0.0e+00 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF02480//PF03767//PF07354//PF13895//PF02121//PF02862 Alphaherpesvirus glycoprotein E//HAD superfamily, subfamily IIIB (Acid phosphatase)//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Phosphatidylinositol transfer protein//DDHD domain GO:0006810//GO:0019497//GO:0007339//GO:0006771 transport//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0016020//GO:0005622//GO:0005576 membrane//intracellular//extracellular region KOG3668 Phosphatidylinositol transfer protein Cluster-8309.24267 BF_2 198.69 2.33 3847 91084681 XP_968452.1 2285 2.7e-254 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925779|ref|XP_008201721.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925781|ref|XP_008201727.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925783|ref|XP_008190266.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|270008928|gb|EFA05376.1| hypothetical protein TcasGA2_TC015542 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 9.6e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0044765//GO:0008272 single-organism transport//sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.24269 BF_2 25.72 0.44 2728 91090278 XP_970876.1 767 2.0e-78 PREDICTED: cell division control protein 42 homolog [Tribolium castaneum]>gi|270014293|gb|EFA10741.1| hypothetical protein TcasGA2_TC012434 [Tribolium castaneum] -- -- -- -- -- K07865 RHOU, WRCH1 Ras homolog gene family, member U http://www.genome.jp/dbget-bin/www_bget?ko:K07865 Q9EQT3 457 7.4e-44 Rho-related GTP-binding protein RhoU OS=Mus musculus GN=Rhou PE=2 SV=1 PF08477//PF03193//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020//GO:0005622 membrane//intracellular KOG0393 Ras-related small GTPase, Rho type Cluster-8309.24271 BF_2 9.00 0.47 1088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24273 BF_2 98.59 1.62 2831 642916439 XP_008191027.1 1004 7.0e-106 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 1.0e-40 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF08702//PF02601//PF09392//PF09036//PF02184//PF01496//PF05478//PF05929//PF00606//PF00046//PF11744//PF05073//PF04111//PF06814//PF08651//PF10459 Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Bcr-Abl oncoprotein oligomerisation domain//HAT (Half-A-TPR) repeat//V-type ATPase 116kDa subunit family//Prominin//Phage capsid scaffolding protein (GPO) serine peptidase//Herpesvirus Glycoprotein B//Homeobox domain//Aluminium activated malate transporter//Baculovirus P24 capsid protein//Autophagy protein Apg6//Lung seven transmembrane receptor//DASH complex subunit Duo1//Peptidase S46 GO:0006914//GO:0009069//GO:0051258//GO:0006468//GO:0009405//GO:0007165//GO:0015031//GO:0007067//GO:0015743//GO:0015991//GO:0006308//GO:0019069//GO:0015992//GO:0006396//GO:0016310//GO:0030168 autophagy//serine family amino acid metabolic process//protein polymerization//protein phosphorylation//pathogenesis//signal transduction//protein transport//mitotic nuclear division//malate transport//ATP hydrolysis coupled proton transport//DNA catabolic process//viral capsid assembly//proton transport//RNA processing//phosphorylation//platelet activation GO:0005096//GO:0070009//GO:0015078//GO:0008855//GO:0003677//GO:0004674//GO:0005102//GO:0008239//GO:0030674 GTPase activator activity//serine-type aminopeptidase activity//hydrogen ion transmembrane transporter activity//exodeoxyribonuclease VII activity//DNA binding//protein serine/threonine kinase activity//receptor binding//dipeptidyl-peptidase activity//protein binding, bridging GO:0016021//GO:0042729//GO:0005622//GO:0033179//GO:0016020//GO:0019028//GO:0005577//GO:0009318//GO:0072686 integral component of membrane//DASH complex//intracellular//proton-transporting V-type ATPase, V0 domain//membrane//viral capsid//fibrinogen complex//exodeoxyribonuclease VII complex//mitotic spindle KOG3850 Predicted membrane protein Cluster-8309.24274 BF_2 2.00 0.35 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24275 BF_2 28.46 0.46 2891 642916441 XP_008191028.1 1909 8.2e-211 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 810 9.2e-85 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF02601//PF08702//PF02184//PF01496//PF05073//PF05531//PF05929//PF05478 Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//HAT (Half-A-TPR) repeat//V-type ATPase 116kDa subunit family//Baculovirus P24 capsid protein//Nucleopolyhedrovirus P10 protein//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin GO:0019069//GO:0006308//GO:0030168//GO:0015991//GO:0006396//GO:0015992//GO:0051258//GO:0007165 viral capsid assembly//DNA catabolic process//platelet activation//ATP hydrolysis coupled proton transport//RNA processing//proton transport//protein polymerization//signal transduction GO:0030674//GO:0008855//GO:0015078//GO:0005102 protein binding, bridging//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//receptor binding GO:0033179//GO:0005577//GO:0005622//GO:0009318//GO:0019028//GO:0016021 proton-transporting V-type ATPase, V0 domain//fibrinogen complex//intracellular//exodeoxyribonuclease VII complex//viral capsid//integral component of membrane KOG3850 Predicted membrane protein Cluster-8309.24276 BF_2 193.67 4.53 2074 642916441 XP_008191028.1 188 2.1e-11 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24277 BF_2 20.91 0.98 1180 642916447 XP_008191031.1 858 2.5e-89 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 4.3e-41 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF13184//PF12919//PF00606//PF00046//PF08702 NusA-like KH domain//TcdA/TcdB catalytic glycosyltransferase domain//Herpesvirus Glycoprotein B//Homeobox domain//Fibrinogen alpha/beta chain family GO:0030168//GO:0007165//GO:0051258 platelet activation//signal transduction//protein polymerization GO:0005102//GO:0030674//GO:0003677//GO:0003723//GO:0016757 receptor binding//protein binding, bridging//DNA binding//RNA binding//transferase activity, transferring glycosyl groups GO:0016020//GO:0005577 membrane//fibrinogen complex KOG3850 Predicted membrane protein Cluster-8309.24279 BF_2 14.00 0.39 1784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24283 BF_2 26.00 0.66 1938 642923802 XP_008193889.1 267 1.4e-20 PREDICTED: uncharacterized protein LOC103313152 [Tribolium castaneum]>gi|270006930|gb|EFA03378.1| hypothetical protein TcasGA2_TC013364 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24284 BF_2 266.39 6.68 1955 91083321 XP_974829.1 1054 7.7e-112 PREDICTED: neuroguidin [Tribolium castaneum]>gi|270007746|gb|EFA04194.1| hypothetical protein TcasGA2_TC014443 [Tribolium castaneum] -- -- -- -- -- K14765 NGDN, LCP5 U3 small nucleolar ribonucleoprotein protein LCP5 http://www.genome.jp/dbget-bin/www_bget?ko:K14765 Q8NEJ9 463 1.1e-44 Neuroguidin OS=Homo sapiens GN=NGDN PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3117 Protein involved in rRNA processing Cluster-8309.24286 BF_2 202.00 3.54 2676 270001924 EEZ98371.1 967 1.3e-101 hypothetical protein TcasGA2_TC000830 [Tribolium castaneum] 194742811 XM_001953858.1 123 5.10101e-55 Drosophila ananassae GF17008 (Dana\GF17008), mRNA -- -- -- -- Q68DU8 428 1.7e-40 BTB/POZ domain-containing protein KCTD16 OS=Homo sapiens GN=KCTD16 PE=2 SV=1 PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- KOG2723 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.24287 BF_2 140.00 3.43 1996 478250794 ENN71286.1 2217 1.1e-246 hypothetical protein YQE_12211, partial [Dendroctonus ponderosae] 590705143 XM_007047292.1 35 3.14265e-06 Theobroma cacao Mediator complex, subunit Med10 isoform 4 (TCM_000672) mRNA, complete cds K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 Q960Z0 1397 5.4e-153 Kinesin-like protein Klp10A OS=Drosophila melanogaster GN=Klp10A PE=1 SV=1 PF00225//PF01857 Kinesin motor domain//Retinoblastoma-associated protein B domain GO:0007017//GO:0051726//GO:0007018 microtubule-based process//regulation of cell cycle//microtubule-based movement GO:0008017//GO:0003777//GO:0005524 microtubule binding//microtubule motor activity//ATP binding GO:0005874//GO:0045298//GO:0005634 microtubule//tubulin complex//nucleus KOG0246 Kinesin-like protein Cluster-8309.24288 BF_2 2.00 2.13 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24289 BF_2 83.51 1.57 2511 91076692 XP_971784.1 851 3.4e-88 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 [Tribolium castaneum]>gi|270001889|gb|EEZ98336.1| hypothetical protein TcasGA2_TC000790 [Tribolium castaneum] -- -- -- -- -- K10768 ALKBH6 alkylated DNA repair protein alkB homolog 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10768 Q6IQE9 559 1.0e-55 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 6 OS=Danio rerio GN=alkbh6 PE=2 SV=1 PF05615//PF03171//PF07361 Tho complex subunit 7//2OG-Fe(II) oxygenase superfamily//Cytochrome b562 GO:0055114//GO:0006118//GO:0022900//GO:0006397 oxidation-reduction process//obsolete electron transport//electron transport chain//mRNA processing GO:0020037//GO:0005506//GO:0016706//GO:0009055//GO:0016491 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//electron carrier activity//oxidoreductase activity GO:0000445//GO:0042597 THO complex part of transcription export complex//periplasmic space KOG3200 Uncharacterized conserved protein Cluster-8309.24290 BF_2 10.00 0.56 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24292 BF_2 984.03 12.21 3659 91079660 XP_966451.1 3241 0.0e+00 PREDICTED: ubiquitin conjugation factor E4 A [Tribolium castaneum]>gi|270003363|gb|EEZ99810.1| hypothetical protein TcasGA2_TC002590 [Tribolium castaneum] -- -- -- -- -- K10596 UBE4A ubiquitin conjugation factor E4 A http://www.genome.jp/dbget-bin/www_bget?ko:K10596 A5PKG6 1540 2.6e-169 Ubiquitin conjugation factor E4 A OS=Bos taurus GN=UBE4A PE=2 SV=1 PF04564//PF10408 U-box domain//Ubiquitin elongating factor core GO:0006511//GO:0044267//GO:0016567 ubiquitin-dependent protein catabolic process//cellular protein metabolic process//protein ubiquitination GO:0034450//GO:0004842 ubiquitin-ubiquitin ligase activity//ubiquitin-protein transferase activity GO:0000151 ubiquitin ligase complex KOG2042 Ubiquitin fusion degradation protein-2 Cluster-8309.24297 BF_2 3.00 0.52 528 871211389 XP_012945364.1 255 9.3e-20 PREDICTED: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial-like [Aplysia californica] -- -- -- -- -- K00167 BCKDHB, bkdA2 2-oxoisovalerate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00167 P21839 225 1.1e-17 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Bos taurus GN=BCKDHB PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0525 Branched chain alpha-keto acid dehydrogenase E1, beta subunit Cluster-8309.24299 BF_2 393.00 14.96 1386 642921679 XP_969670.3 1346 7.5e-146 PREDICTED: sulfatase-modifying factor 1 [Tribolium castaneum] -- -- -- -- -- K13444 SUMF1, FGE sulfatase modifying factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13444 Q8R0F3 923 3.5e-98 Sulfatase-modifying factor 1 OS=Mus musculus GN=Sumf1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2430 BF_2 1.00 1.22 308 -- -- -- -- -- 195493434 XM_002094379.1 36 1.2261e-07 Drosophila yakuba GE21813 (Dyak\GE21813), partial mRNA -- -- -- -- -- -- -- -- PF00869 Flavivirus glycoprotein, central and dimerisation domains -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.24300 BF_2 56.00 1.92 1507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24304 BF_2 172.63 1.96 3970 642916252 XP_008190947.1 2331 1.3e-259 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 94 1.00368e-38 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 582 3.5e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF13405//PF00036//PF00018//PF13499//PF14604//PF12763 EF-hand domain//EF hand//SH3 domain//EF-hand domain pair//Variant SH3 domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.24305 BF_2 602.19 8.10 3399 642932050 XP_008196838.1 1190 2.3e-127 PREDICTED: DCN1-like protein 3 [Tribolium castaneum] 817192303 XM_012416161.1 170 4.84532e-81 PREDICTED: Orussus abietinus DCN1-like protein 3 (LOC105694968), transcript variant X3, mRNA K17823 DCUN1D3 DCN1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17823 Q5E9V1 594 1.2e-59 DCN1-like protein 3 OS=Bos taurus GN=DCUN1D3 PE=2 SV=1 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3077 Uncharacterized conserved protein Cluster-8309.24306 BF_2 136.81 1.80 3466 642932050 XP_008196838.1 1190 2.3e-127 PREDICTED: DCN1-like protein 3 [Tribolium castaneum] 817192303 XM_012416161.1 170 4.94185e-81 PREDICTED: Orussus abietinus DCN1-like protein 3 (LOC105694968), transcript variant X3, mRNA K17823 DCUN1D3 DCN1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17823 Q5E9V1 594 1.2e-59 DCN1-like protein 3 OS=Bos taurus GN=DCUN1D3 PE=2 SV=1 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3077 Uncharacterized conserved protein Cluster-8309.24308 BF_2 146.97 16.23 666 478254922 ENN75156.1 707 4.5e-72 hypothetical protein YQE_08269, partial [Dendroctonus ponderosae]>gi|546673353|gb|ERL84979.1| hypothetical protein D910_02402 [Dendroctonus ponderosae] -- -- -- -- -- K17783 ERV1, GFER, ALR mitochondrial FAD-linked sulfhydryl oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K17783 P55789 414 1.7e-39 FAD-linked sulfhydryl oxidase ALR OS=Homo sapiens GN=GFER PE=1 SV=2 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3355 Mitochondrial sulfhydryl oxidase involved in the biogenesis of cytosolic Fe/S proteins Cluster-8309.24310 BF_2 866.79 14.89 2722 478256708 ENN76890.1 2386 3.8e-266 hypothetical protein YQE_06731, partial [Dendroctonus ponderosae] -- -- -- -- -- K08766 CPT2 carnitine O-palmitoyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08766 Q5U3U3 1611 1.1e-177 Carnitine O-palmitoyltransferase 2, mitochondrial OS=Danio rerio GN=cpt2 PE=2 SV=2 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3719 Carnitine O-acyltransferase CPT2/YAT1 Cluster-8309.24311 BF_2 275.00 14.56 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24315 BF_2 84.95 1.14 3400 478256893 ENN77062.1 359 5.2e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 5.3e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF07975//PF00096//PF13465 HNH endonuclease//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0003676//GO:0004519//GO:0008270//GO:0046872 nucleic acid binding//endonuclease activity//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.24319 BF_2 129.48 0.79 7148 642911198 XP_008199568.1 2708 4.5e-303 PREDICTED: solute carrier family 12 member 4 isoform X2 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.32958e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2008 2.8e-223 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF13520//PF05038//PF03522//PF00324 Amino acid permease//Cytochrome Cytochrome b558 alpha-subunit//Solute carrier family 12//Amino acid permease GO:0003333//GO:0006811//GO:0006865//GO:0055085//GO:0006810 amino acid transmembrane transport//ion transport//amino acid transport//transmembrane transport//transport GO:0020037//GO:0015171//GO:0005215 heme binding//amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.24320 BF_2 63.36 1.20 2493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24322 BF_2 5.00 1.46 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24324 BF_2 86.69 1.29 3094 546672114 ERL84135.1 1143 5.8e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.2e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.24325 BF_2 39.81 0.63 2929 546672114 ERL84135.1 1143 5.5e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.1e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24326 BF_2 248.00 9.94 1331 91091486 XP_968262.1 699 7.6e-71 PREDICTED: phospholipase A1 [Tribolium castaneum]>gi|270000939|gb|EEZ97386.1| hypothetical protein TcasGA2_TC011212 [Tribolium castaneum] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q6Q252 289 1.1e-24 Phospholipase A1 1 OS=Polistes dominula PE=2 SV=1 PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.24327 BF_2 150.41 10.85 867 642934204 XP_008199651.1 677 1.8e-68 PREDICTED: gem-associated protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O42260 301 2.9e-26 Gem-associated protein 2 OS=Xenopus laevis GN=gemin2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24329 BF_2 930.61 12.79 3331 270008598 EFA05046.1 3334 0.0e+00 hypothetical protein TcasGA2_TC015138 [Tribolium castaneum] 795332906 XM_012072956.1 377 0 PREDICTED: Cercocebus atys adaptor-related protein complex 3, delta 1 subunit (AP3D1), mRNA K12396 AP3D1 AP-3 complex subunit delta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12396 P54362 2553 8.2e-287 AP-3 complex subunit delta OS=Drosophila melanogaster GN=g PE=1 SV=4 PF02985//PF01602//PF11698 HEAT repeat//Adaptin N terminal region//V-ATPase subunit H GO:0006886//GO:0015991//GO:0016192 intracellular protein transport//ATP hydrolysis coupled proton transport//vesicle-mediated transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG1059 Vesicle coat complex AP-3, delta subunit Cluster-8309.24336 BF_2 84.88 2.71 1596 478259274 ENN79176.1 252 6.2e-19 hypothetical protein YQE_04360, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24337 BF_2 10.64 0.35 1552 642929392 XP_008195817.1 488 2.6e-46 PREDICTED: neogenin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06583 Neogenin C-terminus -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.24338 BF_2 249.40 1.21 8903 546685536 ERL95023.1 2501 5.7e-279 hypothetical protein D910_12293 [Dendroctonus ponderosae] 780637936 XM_011688946.1 160 4.62547e-75 PREDICTED: Wasmannia auropunctata LIM domain kinase 1 (LOC105449641), transcript variant X2, mRNA K05743 LIMK1 LIM domain kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05743 Q8IR79 1419 6.8e-155 LIM domain kinase 1 OS=Drosophila melanogaster GN=LIMK1 PE=1 SV=1 PF16740//PF00170//PF04871//PF00069//PF07714//PF07544//PF08289//PF06293//PF06160//PF10473//PF10392//PF05929//PF05478//PF00595//PF05531//PF07851//PF06009//PF16331//PF02601//PF04513//PF04728//PF01621//PF00412 Spindle and kinetochore-associated protein 2//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//Protein kinase domain//Protein tyrosine kinase//RNA polymerase II transcription mediator complex subunit 9//Influenza Matrix protein (M1) C-terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Golgi transport complex subunit 5//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin//PDZ domain (Also known as DHR or GLGF)//Nucleopolyhedrovirus P10 protein//TMPIT-like protein//Laminin Domain II//TolA binding protein trimerisation//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Lipoprotein leucine-zipper//Cell fusion glycoprotein K//LIM domain GO:0007155//GO:0006308//GO:0019069//GO:0070206//GO:0006886//GO:0006468//GO:0031110//GO:0007067//GO:0006355//GO:0000090//GO:0015031//GO:0007059//GO:0006891//GO:0000921//GO:0051301//GO:0006357 cell adhesion//DNA catabolic process//viral capsid assembly//protein trimerization//intracellular protein transport//protein phosphorylation//regulation of microtubule polymerization or depolymerization//mitotic nuclear division//regulation of transcription, DNA-templated//mitotic anaphase//protein transport//chromosome segregation//intra-Golgi vesicle-mediated transport//septin ring assembly//cell division//regulation of transcription from RNA polymerase II promoter GO:0003723//GO:0005515//GO:0008855//GO:0008017//GO:0042803//GO:0005198//GO:0008565//GO:0008270//GO:0043565//GO:0001104//GO:0016773//GO:0004672//GO:0005524//GO:0045502//GO:0008134//GO:0003700 RNA binding//protein binding//exodeoxyribonuclease VII activity//microtubule binding//protein homodimerization activity//structural molecule activity//protein transporter activity//zinc ion binding//sequence-specific DNA binding//RNA polymerase II transcription cofactor activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding GO:0019867//GO:0019031//GO:0016020//GO:0000940//GO:0017119//GO:0016021//GO:0005940//GO:0005876//GO:0005737//GO:0030286//GO:0016592//GO:0005667//GO:0019028//GO:0045298//GO:0009318 outer membrane//viral envelope//membrane//condensed chromosome outer kinetochore//Golgi transport complex//integral component of membrane//septin ring//spindle microtubule//cytoplasm//dynein complex//mediator complex//transcription factor complex//viral capsid//tubulin complex//exodeoxyribonuclease VII complex -- -- Cluster-8309.24339 BF_2 350.00 6.76 2454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24342 BF_2 44.93 0.35 5587 270014870 EFA11318.1 336 4.0e-28 hypothetical protein TcasGA2_TC010857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24343 BF_2 140.03 1.18 5271 270014870 EFA11318.1 339 1.7e-28 hypothetical protein TcasGA2_TC010857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24344 BF_2 82.80 0.76 4871 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01635 Coronavirus M matrix/glycoprotein GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.24345 BF_2 130.28 2.91 2163 189235172 XP_001811552.1 2109 3.9e-234 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum]>gi|270003118|gb|EEZ99565.1| hypothetical protein TcasGA2_TC001549 [Tribolium castaneum] 749791080 XM_011150425.1 87 4.22814e-35 PREDICTED: Harpegnathos saltator discoidin domain-containing receptor 2-like (LOC105188791), transcript variant X2, mRNA K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 687 1.3e-70 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF02480 Alphaherpesvirus glycoprotein E GO:0007155 cell adhesion -- -- GO:0016020 membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.24346 BF_2 19.76 0.37 2515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24347 BF_2 220.00 3.17 3186 478253879 ENN74171.1 189 2.5e-11 hypothetical protein YQE_09144, partial [Dendroctonus ponderosae]>gi|546684688|gb|ERL94305.1| hypothetical protein D910_11586 [Dendroctonus ponderosae] 642939598 XM_008196266.1 61 1.77694e-20 PREDICTED: Tribolium castaneum uncharacterized LOC103313285 (LOC103313285), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF04771 Chicken anaemia virus VP-3 protein GO:0019051 induction by virus of host apoptotic process -- -- GO:0042025 host cell nucleus -- -- Cluster-8309.24351 BF_2 6.00 0.44 860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.24352 BF_2 1281.66 19.65 3015 546678907 ERL89445.1 1619 3.6e-177 hypothetical protein D910_06812 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 875 2.8e-92 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF06756//PF00033//PF01073//PF01370 Male sterility protein//Chorion protein S19 C-terminal//Cytochrome b/b6/petB//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0022904//GO:0008210//GO:0007275 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//respiratory electron transport chain//estrogen metabolic process//multicellular organismal development GO:0080019//GO:0003824//GO:0050662//GO:0003854//GO:0016616 fatty-acyl-CoA reductase (alcohol-forming) activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016020//GO:0042600 membrane//chorion KOG1221 Acyl-CoA reductase Cluster-8309.24357 BF_2 700.16 5.60 5514 91092132 XP_975744.1 4022 0.0e+00 PREDICTED: transportin-1 [Tribolium castaneum] 805820211 XM_012294805.1 405 0 PREDICTED: Megachile rotundata transportin-1 (LOC100876705), transcript variant X3, mRNA K18752 TNPO1 transportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18752 Q8BFY9 3552 0.0e+00 Transportin-1 OS=Mus musculus GN=Tnpo1 PE=1 SV=2 PF01602//PF00514//PF03810//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//Importin-beta N-terminal domain//HEAT repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding GO:0030117 membrane coat KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.24368 BF_2 26.87 3.16 643 91083149 XP_971578.1 482 5.4e-46 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 209 1.0e-15 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF05271 Trypsin//Tobravirus 2B protein GO:0019089//GO:0006508 transmission of virus//proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.24371 BF_2 60.07 0.92 3020 642921355 XP_008192834.1 1707 2.3e-187 PREDICTED: uncharacterized protein LOC658985 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G5E8K6 233 7.7e-18 Monocarboxylate transporter 6 OS=Mus musculus GN=Slc16a5 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.24374 BF_2 69.35 0.81 3857 270003223 EEZ99670.1 2222 5.5e-247 hypothetical protein TcasGA2_TC002427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00514//PF11698//PF00651 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//BTB/POZ domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.24376 BF_2 188.00 19.47 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24377 BF_2 122.98 1.59 3533 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.25685e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1903 2.0e-211 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.24378 BF_2 95.62 1.25 3478 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.17417e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1917 4.8e-213 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.24379 BF_2 1197.23 13.61 3968 91090312 XP_972241.1 1990 4.5e-220 PREDICTED: C-terminal-binding protein isoform X2 [Tribolium castaneum]>gi|270013805|gb|EFA10253.1| hypothetical protein TcasGA2_TC012453 [Tribolium castaneum] 642934911 XM_967148.3 534 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K04496 CTBP C-terminal binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04496 O46036 1752 7.4e-194 C-terminal-binding protein OS=Drosophila melanogaster GN=CtBP PE=1 SV=3 PF02826//PF03446//PF00389//PF03493 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit GO:0019521//GO:0055114//GO:0006098//GO:0008152//GO:0006813 D-gluconate metabolic process//oxidation-reduction process//pentose-phosphate shunt//metabolic process//potassium ion transport GO:0004616//GO:0016616//GO:0051287//GO:0015269 phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//calcium-activated potassium channel activity GO:0016020 membrane KOG0067 Transcription factor CtBP Cluster-8309.24380 BF_2 28.38 0.33 3866 642929562 XP_008195885.1 3634 0.0e+00 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] -- -- -- -- -- K11967 ANKIB1 ankyrin repeat and IBR domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11967 Q6ZPS6 1901 3.8e-211 Ankyrin repeat and IBR domain-containing protein 1 OS=Mus musculus GN=Ankib1 PE=1 SV=2 PF00097//PF00023//PF14634//PF13606//PF13639 Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//zinc-RING finger domain//Ankyrin repeat//Ring finger domain -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.24383 BF_2 20.25 0.51 1960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.24384 BF_2 22.53 0.44 2438 795011494 XP_011872774.1 369 2.6e-32 PREDICTED: uncharacterized protein LOC105564750, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.24387 BF_2 147.62 1.14 5720 270008864 EFA05312.1 1750 4.4e-192 hypothetical protein TcasGA2_TC015470 [Tribolium castaneum] 642937640 XM_965135.3 331 2.59324e-170 PREDICTED: Tribolium castaneum inverted formin-2 (LOC658775), mRNA -- -- -- -- Q9C0D6 714 2.5e-73 FH2 domain-containing protein 1 OS=Homo sapiens GN=FHDC1 PE=1 SV=2 PF06367//PF06371 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0016043//GO:0030036 cellular component organization//actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.24388 BF_2 40.03 0.77 2452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24389 BF_2 7.00 0.59 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24391 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24392 BF_2 94.25 1.09 3912 642910837 XP_971522.2 2303 2.3e-256 PREDICTED: probable DNA mismatch repair protein Msh6 [Tribolium castaneum] -- -- -- -- -- K08737 MSH6 DNA mismatch repair protein MSH6 http://www.genome.jp/dbget-bin/www_bget?ko:K08737 Q9VUM0 1519 7.6e-167 Probable DNA mismatch repair protein Msh6 OS=Drosophila melanogaster GN=Msh6 PE=1 SV=2 PF00488//PF01624//PF05190//PF00004//PF00995//PF00910//PF05192//PF05188 MutS domain V//MutS domain I//MutS family domain IV//ATPase family associated with various cellular activities (AAA)//Sec1 family//RNA helicase//MutS domain III//MutS domain II GO:0006904//GO:0016192//GO:0006298 vesicle docking involved in exocytosis//vesicle-mediated transport//mismatch repair GO:0003724//GO:0003723//GO:0005524//GO:0030983 RNA helicase activity//RNA binding//ATP binding//mismatched DNA binding -- -- KOG0217 Mismatch repair ATPase MSH6 (MutS family) Cluster-8309.24393 BF_2 65.00 2.13 1564 546679520 ERL89975.1 244 5.2e-18 hypothetical protein D910_07334 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24394 BF_2 31.85 0.37 3899 642934988 XP_967114.2 1320 2.2e-142 PREDICTED: protein fem-1 homolog CG6966 [Tribolium castaneum] 242011328 XM_002426360.1 61 2.17915e-20 Pediculus humanus corporis Sex-determining protein fem-1, putative, mRNA -- -- -- -- Q2T9K6 431 1.1e-40 Protein fem-1 homolog C OS=Xenopus laevis GN=fem1c PE=2 SV=1 PF05397//PF00023//PF01363//PF13606 Mediator complex subunit 15//Ankyrin repeat//FYVE zinc finger//Ankyrin repeat GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0005515//GO:0046872 RNA polymerase II transcription cofactor activity//protein binding//metal ion binding GO:0016592 mediator complex KOG0508 Ankyrin repeat protein Cluster-8309.24395 BF_2 310.15 4.92 2923 642934988 XP_967114.2 2574 6.4e-288 PREDICTED: protein fem-1 homolog CG6966 [Tribolium castaneum] 242011328 XM_002426360.1 61 1.62858e-20 Pediculus humanus corporis Sex-determining protein fem-1, putative, mRNA -- -- -- -- Q2T9K6 812 5.4e-85 Protein fem-1 homolog C OS=Xenopus laevis GN=fem1c PE=2 SV=1 PF05397//PF00023//PF13606//PF01363 Mediator complex subunit 15//Ankyrin repeat//Ankyrin repeat//FYVE zinc finger GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0005515//GO:0046872 RNA polymerase II transcription cofactor activity//protein binding//metal ion binding GO:0016592 mediator complex KOG0508 Ankyrin repeat protein Cluster-8309.24399 BF_2 15.00 0.62 1294 642913330 XP_008195282.1 1258 1.1e-135 PREDICTED: origin recognition complex subunit 2 [Tribolium castaneum]>gi|270001754|gb|EEZ98201.1| hypothetical protein TcasGA2_TC000631 [Tribolium castaneum] -- -- -- -- -- K02604 ORC2 origin recognition complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02604 Q24168 1015 7.0e-109 Origin recognition complex subunit 2 OS=Drosophila melanogaster GN=Orc2 PE=1 SV=2 PF04084 Origin recognition complex subunit 2 GO:0006260 DNA replication -- -- GO:0000808//GO:0005634 origin recognition complex//nucleus KOG2928 Origin recognition complex, subunit 2 Cluster-8309.24401 BF_2 65.00 5.80 756 91089859 XP_971110.1 584 9.4e-58 PREDICTED: B-cell CLL/lymphoma 7 protein family member A [Tribolium castaneum]>gi|270013648|gb|EFA10096.1| hypothetical protein TcasGA2_TC012275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XFY4 261 1.1e-21 B-cell CLL/lymphoma 7 protein family member A OS=Danio rerio GN=bcl7a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4095 Uncharacterized conserved protein (tumor-specific protein BCL7 in humans) Cluster-8309.24402 BF_2 66.50 2.15 1578 189234531 XP_967948.2 1282 2.3e-138 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K14425 SLC12A1, NKCC2 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14425 Q25479 1019 2.9e-109 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0055085//GO:0006810//GO:0006811 transmembrane transport//transport//ion transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.24404 BF_2 219.00 2.89 3454 -- -- -- -- -- 642934703 XM_008199556.1 74 1.14412e-27 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24405 BF_2 538.56 15.58 1733 642933086 XP_008197254.1 1515 2.4e-165 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1020 2.5e-109 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133//PF03171 Tubulin-tyrosine ligase family//2OG-Fe(II) oxygenase superfamily GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.24407 BF_2 16.58 0.33 2376 91094819 XP_970889.1 1558 3.4e-170 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13949//PF16331 ALIX V-shaped domain binding to HIV//TolA binding protein trimerisation GO:0070206 protein trimerization GO:0005515 protein binding -- -- -- -- Cluster-8309.24409 BF_2 115.98 4.58 1347 727098876 AIY54294.1 1603 1.2e-175 actin 2 [Colaphellus bowringi] 605059338 KJ187399.1 192 1.11412e-93 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1508 4.9e-166 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.24410 BF_2 478.52 4.71 4537 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.54418e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 1.9e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF00278//PF10186 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.24412 BF_2 143.58 0.48 12829 642926088 XP_008194761.1 1377 1.8e-148 PREDICTED: uncharacterized protein LOC103313398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 153 6.2e-08 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF01222//PF06957//PF15220//PF02990 Ergosterol biosynthesis ERG4/ERG24 family//Coatomer (COPI) alpha subunit C-terminus//Hypoxia-inducible lipid droplet-associated//Endomembrane protein 70 GO:0016192//GO:0006886//GO:0008284//GO:0001819//GO:0010884 vesicle-mediated transport//intracellular protein transport//positive regulation of cell proliferation//positive regulation of cytokine production//positive regulation of lipid storage GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0016021//GO:0030126//GO:0016020 integral component of membrane//COPI vesicle coat//membrane -- -- Cluster-8309.24413 BF_2 3.00 23.31 240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24414 BF_2 89.00 2.83 1604 189235800 XP_001808901.1 1195 2.8e-128 PREDICTED: RNA-binding protein 40 [Tribolium castaneum]>gi|270004699|gb|EFA01147.1| hypothetical protein TcasGA2_TC010372 [Tribolium castaneum] -- -- -- -- -- K13157 RNPC3 U11/U12 small nuclear ribonucleoprotein 65 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13157 Q3UZ01 593 7.4e-60 RNA-binding protein 40 OS=Mus musculus GN=Rnpc3 PE=2 SV=2 PF00076//PF02205 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//WH2 motif -- -- GO:0003779//GO:0003676 actin binding//nucleic acid binding -- -- KOG4206 Spliceosomal protein snRNP-U1A/U2B Cluster-8309.24417 BF_2 363.31 3.75 4335 91090274 XP_970683.1 4971 0.0e+00 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1913 1.7e-212 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF07714//PF00400//PF02985//PF00069 Protein tyrosine kinase//WD domain, G-beta repeat//HEAT repeat//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.24418 BF_2 57.00 1.99 1483 688607278 XP_009294113.1 340 3.6e-29 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 721 [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 O88553 330 2.1e-29 Zinc finger protein 37 OS=Rattus norvegicus GN=Zfp37 PE=2 SV=1 PF13465//PF00096//PF04218//PF13912//PF07776//PF00320 Zinc-finger double domain//Zinc finger, C2H2 type//CENP-B N-terminal DNA-binding domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046872//GO:0008270//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//metal ion binding//zinc ion binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.24424 BF_2 13.87 0.57 1304 642934311 XP_008198594.1 632 4.4e-63 PREDICTED: E3 ubiquitin-protein ligase MARCH2-like [Tribolium castaneum]>gi|270012899|gb|EFA09347.1| hypothetical protein TcasGA2_TC001673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD3 219 1.4e-16 E3 ubiquitin-protein ligase MARCH3 OS=Homo sapiens GN=MARCH3 PE=2 SV=1 PF12906 RING-variant domain -- -- GO:0008270 zinc ion binding -- -- KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.24425 BF_2 131.13 5.67 1254 642934311 XP_008198594.1 769 5.5e-79 PREDICTED: E3 ubiquitin-protein ligase MARCH2-like [Tribolium castaneum]>gi|270012899|gb|EFA09347.1| hypothetical protein TcasGA2_TC001673 [Tribolium castaneum] -- -- -- -- -- K10658 MARCH3 E3 ubiquitin-protein ligase MARCH3 http://www.genome.jp/dbget-bin/www_bget?ko:K10658 Q86UD3 293 3.6e-25 E3 ubiquitin-protein ligase MARCH3 OS=Homo sapiens GN=MARCH3 PE=2 SV=1 PF00097//PF02511//PF12906//PF01363//PF05495//PF13639 Zinc finger, C3HC4 type (RING finger)//Thymidylate synthase complementing protein//RING-variant domain//FYVE zinc finger//CHY zinc finger//Ring finger domain GO:0006206//GO:0006231 pyrimidine nucleobase metabolic process//dTMP biosynthetic process GO:0050660//GO:0050797//GO:0008270//GO:0005515//GO:0046872 flavin adenine dinucleotide binding//thymidylate synthase (FAD) activity//zinc ion binding//protein binding//metal ion binding -- -- KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.24427 BF_2 487.58 8.77 2614 198475573 XP_002132955.1 673 1.6e-67 GA26108 [Drosophila pseudoobscura pseudoobscura]>gi|198138883|gb|EDY70357.1| GA26108 [Drosophila pseudoobscura pseudoobscura] 194893319 XM_001977817.1 90 1.10138e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- Q8R4Y4 198 7.7e-14 Stabilin-1 OS=Mus musculus GN=Stab1 PE=1 SV=1 PF07527//PF00558//PF00008//PF04882 Hairy Orange//Vpu protein//EGF-like domain//Peroxin-3 GO:0032801//GO:0006812//GO:0006355//GO:0019076//GO:0007031 receptor catabolic process//cation transport//regulation of transcription, DNA-templated//viral release from host cell//peroxisome organization GO:0005261//GO:0005515//GO:0003677 cation channel activity//protein binding//DNA binding GO:0005779//GO:0033644 integral component of peroxisomal membrane//host cell membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.24430 BF_2 73.05 1.11 3044 -- -- -- -- -- 462464129 APGK01005035.1 75 2.79951e-28 Dendroctonus ponderosae Seq01005037, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24431 BF_2 115.00 14.81 612 478253785 ENN74077.1 553 3.0e-54 hypothetical protein YQE_09050, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0V207 125 5.2e-06 FTS and Hook-interacting protein homolog OS=Danio rerio GN=fam160a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24434 BF_2 2.00 1.79 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24437 BF_2 57.50 0.74 3527 546676485 ERL87486.1 443 9.8e-41 hypothetical protein D910_04878 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03213 Poxvirus P35 protein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.24438 BF_2 45.59 0.56 3674 546676485 ERL87486.1 295 1.5e-23 hypothetical protein D910_04878 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24439 BF_2 17.82 0.40 2144 642917250 XP_967285.3 1408 7.5e-153 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X2 [Tribolium castaneum] 642917249 XM_962192.3 115 1.14062e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q9H4F8 312 3.8e-27 SPARC-related modular calcium-binding protein 1 OS=Homo sapiens GN=SMOC1 PE=1 SV=1 PF04347//PF13405//PF10591//PF13499//PF13202//PF00036//PF00050//PF07648 Flagellar biosynthesis protein, FliO//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF hand//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0007165//GO:0044781 signal transduction//bacterial-type flagellum organization GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016021//GO:0005578 integral component of membrane//proteinaceous extracellular matrix KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.24440 BF_2 1386.64 12.21 5037 748995296 AJE75670.1 1570 2.9e-171 putative glycosyl hydrolase [Chrysomela lapponica] 642917249 XM_962192.3 115 2.70386e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1035 1.3e-110 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF13499//PF00506//PF13405//PF10591//PF00232//PF01977//PF00036//PF09398 EF-hand domain pair//Influenza virus nucleoprotein//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//Glycosyl hydrolase family 1//3-octaprenyl-4-hydroxybenzoate carboxy-lyase//EF hand//FOP N terminal dimerisation domain GO:0007165//GO:0034453//GO:0006744//GO:0005975 signal transduction//microtubule anchoring//ubiquinone biosynthetic process//carbohydrate metabolic process GO:0016831//GO:0004553//GO:0005198//GO:0005509 carboxy-lyase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//structural molecule activity//calcium ion binding GO:0005815//GO:0005886//GO:0005578 microtubule organizing center//plasma membrane//proteinaceous extracellular matrix KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.24441 BF_2 18.93 0.44 2102 642917250 XP_967285.3 1439 1.9e-156 PREDICTED: SPARC-related modular calcium-binding protein 2 isoform X2 [Tribolium castaneum] 642917249 XM_962192.3 115 1.1179e-50 PREDICTED: Tribolium castaneum SPARC-related modular calcium-binding protein 2 (LOC655633), transcript variant X2, mRNA -- -- -- -- Q9H4F8 316 1.3e-27 SPARC-related modular calcium-binding protein 1 OS=Homo sapiens GN=SMOC1 PE=1 SV=1 PF04347//PF13499//PF13405//PF10591//PF13202//PF07648//PF00036//PF00050 Flagellar biosynthesis protein, FliO//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain GO:0007165//GO:0044781 signal transduction//bacterial-type flagellum organization GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016021//GO:0005578 integral component of membrane//proteinaceous extracellular matrix KOG4578 Uncharacterized conserved protein, contains KAZAL and TY domains Cluster-8309.24442 BF_2 12.00 0.45 1411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24443 BF_2 331.92 6.07 2576 642919719 XP_008192036.1 1193 7.7e-128 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9VNL4 798 2.0e-83 Glutaredoxin domain-containing cysteine-rich protein CG31559 OS=Drosophila melanogaster GN=CG31559 PE=1 SV=2 PF00684//PF00462//PF03334 DnaJ central domain//Glutaredoxin//Na+/H+ antiporter subunit GO:0015672//GO:0015992//GO:0045454//GO:0006118 monovalent inorganic cation transport//proton transport//cell redox homeostasis//obsolete electron transport GO:0031072//GO:0051082//GO:0009055//GO:0005451//GO:0015035 heat shock protein binding//unfolded protein binding//electron carrier activity//monovalent cation:proton antiporter activity//protein disulfide oxidoreductase activity -- -- KOG2824 Glutaredoxin-related protein Cluster-8309.24445 BF_2 82.43 5.59 904 153792270 NP_001093280.1 350 1.5e-30 malate dehydrogenase [Bombyx mori]>gi|95103050|gb|ABF51466.1| malate dehydrogenase [Bombyx mori] -- -- -- -- -- K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P78715 165 1.8e-10 Malic enzyme, hydrogenosomal OS=Neocallimastix frontalis PE=1 SV=1 -- -- GO:0044710//GO:0006099//GO:0006108 single-organism metabolic process//tricarboxylic acid cycle//malate metabolic process GO:0004470//GO:0000166//GO:0016616 malic enzyme activity//nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.24449 BF_2 121.14 10.79 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24450 BF_2 138.86 1.49 4176 642931762 XP_008196718.1 2808 0.0e+00 PREDICTED: exocyst complex component 7 [Tribolium castaneum]>gi|270011742|gb|EFA08190.1| hypothetical protein TcasGA2_TC005817 [Tribolium castaneum] -- -- -- -- -- K07195 EXOC7, EXO70 exocyst complex component 7 http://www.genome.jp/dbget-bin/www_bget?ko:K07195 Q9VSJ8 1391 5.6e-152 Exocyst complex component 7 OS=Drosophila melanogaster GN=exo70 PE=1 SV=2 PF00700//PF10392//PF02214//PF03081 Bacterial flagellin C-terminal helical region//Golgi transport complex subunit 5//BTB/POZ domain//Exo70 exocyst complex subunit GO:0006891//GO:0006887//GO:0051260//GO:0071973 intra-Golgi vesicle-mediated transport//exocytosis//protein homooligomerization//bacterial-type flagellum-dependent cell motility GO:0005198 structural molecule activity GO:0000145//GO:0017119 exocyst//Golgi transport complex KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.24452 BF_2 26.89 1.87 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24456 BF_2 4.00 0.66 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24458 BF_2 766.03 7.03 4845 546675277 ERL86513.1 2764 9.9e-310 hypothetical protein D910_03917 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PD19 1667 6.5e-184 UPF0668 protein C10orf76 homolog OS=Mus musculus PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG4654 Uncharacterized conserved protein Cluster-8309.24460 BF_2 44.85 1.09 2008 546683711 ERL93489.1 1520 7.3e-166 hypothetical protein D910_10779 [Dendroctonus ponderosae] -- -- -- -- -- K11314 TADA2A, ADA2 transcriptional adapter 2-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11314 Q6AYE3 647 5.1e-66 Transcriptional adapter 2-alpha OS=Rattus norvegicus GN=Tada2a PE=2 SV=1 PF04433//PF00643 SWIRM domain//B-box zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005622 intracellular KOG0457 Histone acetyltransferase complex SAGA/ADA, subunit ADA2 Cluster-8309.24466 BF_2 342.02 11.58 1523 642926165 XP_008194811.1 1671 1.7e-183 PREDICTED: vinculin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 960 2.0e-102 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF01442//PF06009 Vinculin family//Apolipoprotein A1/A4/E domain//Laminin Domain II GO:0042157//GO:0007155//GO:0006869 lipoprotein metabolic process//cell adhesion//lipid transport GO:0051015//GO:0008289 actin filament binding//lipid binding GO:0005576 extracellular region KOG3681 Alpha-catenin Cluster-8309.24467 BF_2 9.00 0.56 956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24469 BF_2 421.40 12.23 1728 642914239 XP_008201604.1 450 7.4e-42 PREDICTED: cytochrome b561 domain-containing protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E965 167 2.0e-10 Cytochrome b561 domain-containing protein 2 OS=Bos taurus GN=CYB561D2 PE=2 SV=1 PF07690//PF03188//PF00672//PF02038 Major Facilitator Superfamily//Eukaryotic cytochrome b561//HAMP domain//ATP1G1/PLM/MAT8 family GO:0006811//GO:0007165//GO:0055085 ion transport//signal transduction//transmembrane transport GO:0005216//GO:0004871 ion channel activity//signal transducer activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.24474 BF_2 109.47 0.94 5145 91088827 XP_970265.1 2242 3.5e-249 PREDICTED: THO complex subunit 1 [Tribolium castaneum]>gi|270012332|gb|EFA08780.1| hypothetical protein TcasGA2_TC006470 [Tribolium castaneum] 805773091 XM_003701730.2 90 2.18115e-36 PREDICTED: Megachile rotundata THO complex subunit 1 (LOC100880227), mRNA K12878 THOC1 THO complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12878 Q96FV9 1053 1.1e-112 THO complex subunit 1 OS=Homo sapiens GN=THOC1 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2491 Nuclear matrix protein Cluster-8309.24475 BF_2 178.76 2.01 4011 270297184 NP_001161900.1 704 6.1e-71 cuticular protein analogous to peritrophins 1-I precursor [Tribolium castaneum]>gi|268373732|gb|ACZ04319.1| CPAP1-I [Tribolium castaneum]>gi|270014341|gb|EFA10789.1| hypothetical protein TcasGA2_TC012766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05412 Equine arterivirus Nsp2-type cysteine proteinase GO:0016032//GO:0019082 viral process//viral protein processing -- -- -- -- -- -- Cluster-8309.24482 BF_2 768.86 6.99 4888 91094031 XP_967783.1 1988 9.6e-220 PREDICTED: protein germ cell-less [Tribolium castaneum]>gi|270004797|gb|EFA01245.1| germ cell-less [Tribolium castaneum] -- -- -- -- -- K10485 BTBD13, GMCL1, GCL BTB/POZ domain-containing protein 13 (germ cell-less protein-like 1) http://www.genome.jp/dbget-bin/www_bget?ko:K10485 Q01820 1009 1.3e-107 Protein germ cell-less OS=Drosophila melanogaster GN=gcl PE=2 SV=1 PF00651//PF02096 BTB/POZ domain//60Kd inner membrane protein GO:0051205 protein insertion into membrane GO:0005515 protein binding GO:0016021 integral component of membrane KOG1239 Inner membrane protein translocase involved in respiratory chain assembly Cluster-8309.24483 BF_2 603.53 7.63 3597 270002066 EEZ98513.1 3770 0.0e+00 hypothetical protein TcasGA2_TC001014 [Tribolium castaneum] -- -- -- -- -- K08626 ADAMTS12 a disintegrin and metalloproteinase with thrombospondin motifs 12 http://www.genome.jp/dbget-bin/www_bget?ko:K08626 Q9UKP4 1763 3.6e-195 A disintegrin and metalloproteinase with thrombospondin motifs 7 OS=Homo sapiens GN=ADAMTS7 PE=1 SV=2 PF10462//PF00413//PF05986//PF01562//PF01421 Peptidase M66//Matrixin//ADAM-TS Spacer 1//Reprolysin family propeptide//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.24486 BF_2 168.03 1.38 5366 91077932 XP_974190.1 2678 1.0e-299 PREDICTED: conserved oligomeric Golgi complex subunit 7 [Tribolium castaneum] 820862785 XM_003697932.2 121 1.33129e-53 PREDICTED: Apis florea U4/U6 small nuclear ribonucleoprotein Prp4 (LOC100870360), mRNA K12662 PRPF4, PRP4 U4/U6 small nuclear ribonucleoprotein PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K12662 Q3MHE2 1614 1.0e-177 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus GN=PRPF4 PE=2 SV=1 PF10191//PF10392//PF00400//PF02468 Golgi complex component 7 (COG7)//Golgi transport complex subunit 5//WD domain, G-beta repeat//Photosystem II reaction centre N protein (psbN) GO:0006891//GO:0015979//GO:0006886 intra-Golgi vesicle-mediated transport//photosynthesis//intracellular protein transport GO:0005515 protein binding GO:0016020//GO:0017119//GO:0009523//GO:0009539 membrane//Golgi transport complex//photosystem II//photosystem II reaction center KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) Cluster-8309.24488 BF_2 413.33 4.33 4282 189238033 XP_966902.2 1468 1.7e-159 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 242 5.78091e-121 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 844 1.6e-88 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF02535//PF15048//PF01757//PF00892 ZIP Zinc transporter//Organic solute transporter subunit beta protein//Acyltransferase family//EamA-like transporter family GO:0006810//GO:0015721//GO:0030001//GO:0055085 transport//bile acid and bile salt transport//metal ion transport//transmembrane transport GO:0005215//GO:0046982//GO:0016747//GO:0046873 transporter activity//protein heterodimerization activity//transferase activity, transferring acyl groups other than amino-acyl groups//metal ion transmembrane transporter activity GO:0016021//GO:0005886//GO:0016020 integral component of membrane//plasma membrane//membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.24491 BF_2 12.84 0.42 1570 642914654 XP_008190301.1 630 9.0e-63 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24492 BF_2 30.98 0.57 2579 749789601 XP_011148114.1 396 2.0e-35 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Harpegnathos saltator] 168488035 EU365789.1 205 1.28191e-100 Drosophila yakuba strain CY27 tan gene, 5' upstream region -- -- -- -- -- -- -- -- PF08408//PF04545//PF00658 DNA polymerase family B viral insert//Sigma-70, region 4//Poly-adenylate binding protein, unique domain GO:0006352//GO:0006355//GO:0006260 DNA-templated transcription, initiation//regulation of transcription, DNA-templated//DNA replication GO:0003887//GO:0003723//GO:0003677//GO:0003700//GO:0016987 DNA-directed DNA polymerase activity//RNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667//GO:0042575 transcription factor complex//DNA polymerase complex -- -- Cluster-8309.24494 BF_2 878.12 10.79 3691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00839 Cysteine rich repeat -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.24495 BF_2 200.00 14.66 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24497 BF_2 100.00 2.38 2042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24501 BF_2 82.00 5.49 912 270015247 EFA11695.1 556 2.0e-54 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24502 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24503 BF_2 32.91 0.57 2689 642939351 XP_008197109.1 760 1.3e-77 PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum]>gi|642939353|ref|XP_008197119.1| PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24505 BF_2 167.12 4.51 1837 642937544 XP_008199089.1 1005 3.5e-106 PREDICTED: major facilitator superfamily domain-containing protein 9-like isoform X2 [Tribolium castaneum]>gi|270001229|gb|EEZ97676.1| hypothetical protein TcasGA2_TC016221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0T7 460 2.2e-44 Major facilitator superfamily domain-containing protein 9 OS=Mus musculus GN=Mfsd9 PE=2 SV=1 PF00083//PF05121//PF07690 Sugar (and other) transporter//Gas vesicle protein K//Major Facilitator Superfamily GO:0031412//GO:0055085 gas vesicle organization//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.24509 BF_2 241.25 5.83 2017 642929605 XP_008195901.1 899 7.5e-94 PREDICTED: polyadenylate-binding protein 2 isoform X1 [Tribolium castaneum]>gi|270010566|gb|EFA07014.1| hypothetical protein TcasGA2_TC009984 [Tribolium castaneum] 196012775 XM_002116214.1 70 1.11053e-25 Trichoplax adhaerens hypothetical protein, mRNA K14396 PABPN1, PABP2 polyadenylate-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14396 Q28ZX3 645 8.7e-66 Polyadenylate-binding protein 2 OS=Drosophila pseudoobscura pseudoobscura GN=Pabp2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.24510 BF_2 172.50 5.55 1588 189239479 XP_975440.2 899 5.9e-94 PREDICTED: polyadenylate-binding protein 2 isoform X2 [Tribolium castaneum] 196012775 XM_002116214.1 70 8.70155e-26 Trichoplax adhaerens hypothetical protein, mRNA K14396 PABPN1, PABP2 polyadenylate-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14396 Q28ZX3 645 6.8e-66 Polyadenylate-binding protein 2 OS=Drosophila pseudoobscura pseudoobscura GN=Pabp2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.24511 BF_2 39.33 0.57 3182 91080725 XP_975392.1 1688 3.8e-185 PREDICTED: arginine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270005463|gb|EFA01911.1| hypothetical protein TcasGA2_TC007521 [Tribolium castaneum] 306980173 CP002198.1 65 1.06055e-22 Cyanothece sp. PCC 7822, complete genome K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 A7YW98 1354 8.4e-148 Arginine--tRNA ligase, cytoplasmic OS=Bos taurus GN=RARS PE=2 SV=1 PF00133//PF09334//PF03485//PF00750//PF07062//PF05746 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Arginyl tRNA synthetase N terminal domain//tRNA synthetases class I (R)//Clc-like//DALR anticodon binding domain GO:0006525//GO:0006560//GO:0006420//GO:0006418 arginine metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005524//GO:0004814//GO:0000166//GO:0004812 ATP binding//arginine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG4426 Arginyl-tRNA synthetase Cluster-8309.24513 BF_2 51.88 0.57 4067 642934848 XP_008197836.1 1120 3.6e-119 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 3.47073e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA K10423 CLIP3_4 CAP-Gly domain-containing linker protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10423 B9EHT4 189 1.3e-12 CAP-Gly domain-containing linker protein 3 OS=Mus musculus GN=Clip3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4568 Cytoskeleton-associated protein and related proteins Cluster-8309.24514 BF_2 1333.44 29.33 2189 642923298 XP_008193694.1 1320 1.2e-142 PREDICTED: presenilins-associated rhomboid-like protein, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 B0BNE5 821 3.7e-86 S-formylglutathione hydrolase OS=Rattus norvegicus GN=Esd PE=2 SV=1 PF07224//PF07578//PF00326//PF07819//PF10503//PF01764//PF04612//PF12740//PF01694 Chlorophyllase//Lipid A Biosynthesis N-terminal domain//Prolyl oligopeptidase family//PGAP1-like protein//Esterase PHB depolymerase//Lipase (class 3)//Type II secretion system (T2SS), protein M//Chlorophyllase enzyme//Rhomboid family GO:0006508//GO:0006858//GO:0006505//GO:0009245//GO:0015996//GO:0015994//GO:0006886//GO:0006629 proteolysis//extracellular transport//GPI anchor metabolic process//lipid A biosynthetic process//chlorophyll catabolic process//chlorophyll metabolic process//intracellular protein transport//lipid metabolic process GO:0008236//GO:0008915//GO:0004252//GO:0016788//GO:0047746 serine-type peptidase activity//lipid-A-disaccharide synthase activity//serine-type endopeptidase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3101 Esterase D Cluster-8309.24515 BF_2 101.42 0.93 4860 478251097 ENN71573.1 1384 1.0e-149 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9WU40 209 7.6e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.24516 BF_2 47.37 0.45 4732 642937864 XP_008200330.1 1951 1.8e-215 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVG3 1152 3.3e-124 Protein FAM91A1 OS=Mus musculus GN=Fam91a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.24517 BF_2 696.24 16.80 2021 91089077 XP_971296.1 743 9.2e-76 PREDICTED: density-regulated protein [Tribolium castaneum]>gi|270012410|gb|EFA08858.1| hypothetical protein TcasGA2_TC006559 [Tribolium castaneum] 389609388 AK401684.1 173 6.15205e-83 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 667 2.5e-68 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.24518 BF_2 58.59 0.81 3320 612342210 AHW99830.1 4282 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] -- -- -- -- -- K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 3114 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.24520 BF_2 22.55 0.64 1765 270007787 EFA04235.1 1057 3.1e-112 hypothetical protein TcasGA2_TC014488 [Tribolium castaneum] -- -- -- -- -- K13751 SLC24A3, NCKX3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13751 Q9HC58 492 4.2e-48 Sodium/potassium/calcium exchanger 3 OS=Homo sapiens GN=SLC24A3 PE=2 SV=4 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.24521 BF_2 52.08 0.46 4993 642927107 XP_008195140.1 5178 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] 642927106 XM_008196918.1 219 4.11969e-108 PREDICTED: Tribolium castaneum sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (LOC660611), mRNA -- -- -- -- Q22328 693 5.9e-71 Protein lev-9 OS=Caenorhabditis elegans GN=lev-9 PE=1 SV=3 PF02793//PF00095 Hormone receptor domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0007186 G-protein coupled receptor signaling pathway GO:0030414//GO:0004930 peptidase inhibitor activity//G-protein coupled receptor activity GO:0005576//GO:0016020 extracellular region//membrane KOG4297 C-type lectin Cluster-8309.24522 BF_2 12.00 0.35 1728 625256567 XP_007619640.1 546 5.5e-53 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like, partial [Cricetulus griseus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q61116 513 1.5e-50 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF00096//PF13465//PF07649//PF13912//PF02892//PF04810 Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888//GO:0055114 intracellular protein transport//ER to Golgi vesicle-mediated transport//oxidation-reduction process GO:0003677//GO:0046872//GO:0047134//GO:0008270 DNA binding//metal ion binding//protein-disulfide reductase activity//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.24523 BF_2 116.00 1.46 3600 850315944 XP_012863126.1 259 2.2e-19 PREDICTED: zinc finger protein 709-like [Echinops telfairi] -- -- -- -- -- K04462 EVI1 ecotropic virus integration site 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04462 A2T812 249 1.3e-19 Zinc finger protein 287 OS=Pongo pygmaeus GN=ZNF287 PE=3 SV=1 PF02892//PF13912//PF01428//PF16622//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.24526 BF_2 164.69 1.78 4158 642917767 XP_008191359.1 1275 3.9e-137 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 512 4.7e-50 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05834//PF07992//PF00732//PF01266//PF05199//PF02254 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0055114//GO:0016117//GO:0006813//GO:0044710 oxidation-reduction process//carotenoid biosynthetic process//potassium ion transport//single-organism metabolic process GO:0050660//GO:0016491//GO:0016705//GO:0016614 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.24527 BF_2 63.21 0.96 3034 91090484 XP_968697.1 513 6.4e-49 PREDICTED: DNA-directed RNA polymerase III subunit RPC4 [Tribolium castaneum]>gi|270013359|gb|EFA09807.1| hypothetical protein TcasGA2_TC011952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05423 164 7.8e-10 DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens GN=POLR3D PE=1 SV=2 PF05132 RNA polymerase III RPC4 GO:0006206//GO:0006144//GO:0006383//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005666 nucleolus//DNA-directed RNA polymerase III complex -- -- Cluster-8309.24528 BF_2 2048.74 8.49 10383 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.6e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF01155//PF00632//PF02891//PF00397//PF00168//PF05430 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//HECT-domain (ubiquitin-transferase)//MIZ/SP-RING zinc finger//WW domain//C2 domain//S-adenosyl-L-methionine-dependent methyltransferase GO:0055114//GO:0006464//GO:0016567 oxidation-reduction process//cellular protein modification process//protein ubiquitination GO:0008270//GO:0016645//GO:0016151//GO:0004842//GO:0005515 zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors//nickel cation binding//ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.24529 BF_2 2.00 73.08 204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24530 BF_2 266.71 0.96 11958 189235646 XP_968349.2 3078 0.0e+00 PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Tribolium castaneum] 642917490 XM_963256.3 740 0 PREDICTED: Tribolium castaneum peripheral plasma membrane protein CASK (LOC656749), transcript variant X4, mRNA K06103 CASK calcium/calmodulin-dependent serine protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06103 Q24210 2193 1.6e-244 Peripheral plasma membrane protein CASK OS=Drosophila melanogaster GN=CASK PE=1 SV=4 PF13180//PF00018//PF14604//PF01003//PF00570//PF07714//PF00069//PF00595//PF01502 PDZ domain//SH3 domain//Variant SH3 domain//Flavivirus capsid protein C//HRDC domain//Protein tyrosine kinase//Protein kinase domain//PDZ domain (Also known as DHR or GLGF)//Phosphoribosyl-AMP cyclohydrolase GO:0006468//GO:0000105//GO:0006547 protein phosphorylation//histidine biosynthetic process//histidine metabolic process GO:0005198//GO:0005515//GO:0005524//GO:0004672//GO:0004635//GO:0003676 structural molecule activity//protein binding//ATP binding//protein kinase activity//phosphoribosyl-AMP cyclohydrolase activity//nucleic acid binding GO:0019028//GO:0005622 viral capsid//intracellular KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.24531 BF_2 268.00 72.66 441 642926629 XP_008194947.1 203 8.3e-14 PREDICTED: uncharacterized protein LOC103313441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16497//PF01064 MHC-I family domain//Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0006955//GO:0007178 phosphorylation//serine family amino acid metabolic process//immune response//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.24532 BF_2 138.71 1.90 3348 189242339 XP_967217.2 1417 1.1e-153 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|642939487|ref|XP_008190837.1| PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016564|gb|EFA13010.1| hypothetical protein TcasGA2_TC001975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 292 1.2e-24 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF01238//PF00560 Leucine rich repeat//Phosphomannose isomerase type I//Leucine Rich Repeat GO:0005975//GO:0006000//GO:0006013 carbohydrate metabolic process//fructose metabolic process//mannose metabolic process GO:0008270//GO:0005515//GO:0004476 zinc ion binding//protein binding//mannose-6-phosphate isomerase activity -- -- -- -- Cluster-8309.24533 BF_2 3.52 0.43 629 642924167 XP_008194036.1 525 5.4e-51 PREDICTED: secernin-3 isoform X1 [Tribolium castaneum]>gi|270007848|gb|EFA04296.1| hypothetical protein TcasGA2_TC014587 [Tribolium castaneum] -- -- -- -- -- K14358 SCRN secernin http://www.genome.jp/dbget-bin/www_bget?ko:K14358 Q803W1 320 1.3e-28 Secernin-3 OS=Danio rerio GN=scrn3 PE=2 SV=1 -- -- GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.24534 BF_2 483.48 9.69 2374 642924167 XP_008194036.1 1755 4.8e-193 PREDICTED: secernin-3 isoform X1 [Tribolium castaneum]>gi|270007848|gb|EFA04296.1| hypothetical protein TcasGA2_TC014587 [Tribolium castaneum] -- -- -- -- -- K14358 SCRN secernin http://www.genome.jp/dbget-bin/www_bget?ko:K14358 Q803W1 906 5.6e-96 Secernin-3 OS=Danio rerio GN=scrn3 PE=2 SV=1 PF03577 Peptidase family C69 GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.24536 BF_2 460.08 3.91 5207 189237519 XP_973030.2 3459 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.1e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF03470//PF01667//PF13465 XS zinc finger domain//Ribosomal protein S27//Zinc-finger double domain GO:0031047//GO:0006412//GO:0042254 gene silencing by RNA//translation//ribosome biogenesis GO:0003735//GO:0046872 structural constituent of ribosome//metal ion binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.24538 BF_2 415.39 7.10 2733 270004255 EFA00703.1 1234 1.4e-132 hypothetical protein TcasGA2_TC003582 [Tribolium castaneum] 746868949 XM_011067317.1 84 2.49237e-33 PREDICTED: Acromyrmex echinatior IWS1-like protein (LOC105152830), mRNA K17498 SPN1, IWS1 transcription factor SPN1 http://www.genome.jp/dbget-bin/www_bget?ko:K17498 Q3SWT4 759 7.1e-79 Protein IWS1 homolog OS=Rattus norvegicus GN=Iws1 PE=2 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG1793 Uncharacterized conserved protein Cluster-8309.24539 BF_2 269.01 5.65 2280 642916576 XP_969029.3 1234 1.2e-132 PREDICTED: protein IWS1 homolog isoform X1 [Tribolium castaneum] 746868949 XM_011067317.1 84 2.07532e-33 PREDICTED: Acromyrmex echinatior IWS1-like protein (LOC105152830), mRNA K17498 SPN1, IWS1 transcription factor SPN1 http://www.genome.jp/dbget-bin/www_bget?ko:K17498 Q3SWT4 759 5.9e-79 Protein IWS1 homolog OS=Rattus norvegicus GN=Iws1 PE=2 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG1793 Uncharacterized conserved protein Cluster-8309.24542 BF_2 6.00 0.52 766 817061123 XP_012252151.1 314 1.9e-26 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17047//PF01673 Synaptotagmin-like mitochondrial-lipid-binding domain//Herpesvirus putative major envelope glycoprotein -- -- GO:0008289 lipid binding GO:0019031 viral envelope -- -- Cluster-8309.24547 BF_2 42.00 2.84 905 344250492 EGW06596.1 1125 2.1e-120 Elongation factor 1-alpha 1 [Cricetulus griseus] 767942081 XM_011535514.1 905 0 PREDICTED: Homo sapiens eukaryotic translation elongation factor 1 alpha 1 (EEF1A1), transcript variant X1, mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P17507 855 1.7e-90 Elongation factor 1-alpha, oocyte form OS=Xenopus laevis GN=eef1ao PE=1 SV=1 PF02774//PF03144 Semialdehyde dehydrogenase, dimerisation domain//Elongation factor Tu domain 2 GO:0055114//GO:0008652//GO:0000051 oxidation-reduction process//cellular amino acid biosynthetic process//obsolete urea cycle intermediate metabolic process GO:0016620//GO:0005525//GO:0003942//GO:0046983 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//GTP binding//N-acetyl-gamma-glutamyl-phosphate reductase activity//protein dimerization activity GO:0005737 cytoplasm -- -- Cluster-8309.24549 BF_2 283.48 1.17 10466 642910592 XP_008200017.1 2262 3.5e-251 PREDICTED: uncharacterized protein LOC103314818 isoform X2 [Tribolium castaneum] 642910591 XM_008201795.1 107 1.57837e-45 PREDICTED: Tribolium castaneum uncharacterized LOC103314818 (LOC103314818), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07359//PF08272 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)//Topoisomerase I zinc-ribbon-like GO:0042742//GO:0006265 defense response to bacterium//DNA topological change GO:0003918//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding GO:0005694 chromosome -- -- Cluster-8309.24550 BF_2 250.89 1.55 7057 332376376 AEE63328.1 726 3.0e-73 unknown [Dendroctonus ponderosae]>gi|546675031|gb|ERL86292.1| hypothetical protein D910_03700 [Dendroctonus ponderosae] -- -- -- -- -- K01493 comEB dCMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01493 P32321 580 1.0e-57 Deoxycytidylate deaminase OS=Homo sapiens GN=DCTD PE=1 SV=2 PF04934//PF09726//PF03261//PF00383 MED6 mediator sub complex component//Transmembrane protein//Cyclin-dependent kinase 5 activator protein//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0045859//GO:0006357 regulation of protein kinase activity//regulation of transcription from RNA polymerase II promoter GO:0016534//GO:0001104//GO:0008270 cyclin-dependent protein kinase 5 activator activity//RNA polymerase II transcription cofactor activity//zinc ion binding GO:0016533//GO:0016021//GO:0016592 cyclin-dependent protein kinase 5 holoenzyme complex//integral component of membrane//mediator complex KOG3127 Deoxycytidylate deaminase Cluster-8309.24552 BF_2 11.00 2.29 488 556774071 XP_005982177.1 160 8.8e-09 PREDICTED: actin, cytoplasmic 1 isoform X1 [Pantholops hodgsonii]>gi|556774073|ref|XP_005982178.1| PREDICTED: actin, cytoplasmic 1 isoform X2 [Pantholops hodgsonii] 164690869 AK309997.1 487 0 Homo sapiens cDNA, FLJ17039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24560 BF_2 11.88 1.87 553 270002932 EEZ99379.1 233 3.4e-17 serine protease H47 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P16295 133 5.6e-07 Coagulation factor IX (Fragment) OS=Cavia porcellus GN=F9 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.24561 BF_2 8.00 0.37 1202 291170322 ADD82417.1 255 2.1e-19 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 119 3.77178e-53 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- PF03278 IpaB/EvcA family GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.24564 BF_2 159.19 2.79 2674 728417168 AIY68335.1 1661 4.3e-182 esterase, partial [Leptinotarsa decemlineata] 801385926 XM_012200861.1 84 2.43954e-33 PREDICTED: Atta cephalotes transcription initiation factor IIE subunit beta (LOC105619342), mRNA -- -- -- -- Q8R0W5 391 3.3e-36 Carboxylesterase 4A OS=Mus musculus GN=Ces4a PE=2 SV=2 PF02186//PF02230//PF07859//PF01764 TFIIE beta subunit core domain//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Lipase (class 3) GO:0006629//GO:0006367//GO:0008152 lipid metabolic process//transcription initiation from RNA polymerase II promoter//metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.24565 BF_2 561.44 4.57 5426 91091178 XP_971714.1 2347 2.5e-261 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] 564254995 XM_006266415.1 37 6.67539e-07 PREDICTED: Alligator mississippiensis F-box protein 21 (FBXO21), mRNA K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q63448 1376 4.0e-150 Peroxisomal acyl-coenzyme A oxidase 3 OS=Rattus norvegicus GN=Acox3 PE=1 SV=1 PF12937//PF02770//PF00441//PF00646//PF08755//PF01756 F-box-like//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//F-box domain//Hemimethylated DNA-binding protein YccV like//Acyl-CoA oxidase GO:0055114//GO:0006118//GO:0006631//GO:0006635//GO:0006637 oxidation-reduction process//obsolete electron transport//fatty acid metabolic process//fatty acid beta-oxidation//acyl-CoA metabolic process GO:0016627//GO:0003997//GO:0005515//GO:0003995//GO:0003677 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA oxidase activity//protein binding//acyl-CoA dehydrogenase activity//DNA binding GO:0005777 peroxisome KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.24566 BF_2 66.93 0.37 7836 642927844 XP_008195423.1 1234 4.1e-132 PREDICTED: INO80 complex subunit D-B-like [Tribolium castaneum]>gi|270010242|gb|EFA06690.1| hypothetical protein TcasGA2_TC009621 [Tribolium castaneum] -- -- -- -- -- K11668 INO80D INO80 complex subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K11668 Q66JY2 239 4.1e-18 INO80 complex subunit D OS=Mus musculus GN=Ino80d PE=2 SV=3 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24567 BF_2 1.00 1.40 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24569 BF_2 173.86 1.57 4926 270004778 EFA01226.1 1385 8.0e-150 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] 5815422 AF177773.1 73 5.88718e-27 Lymantria dispar Lydia retrotransposon, complete sequence -- -- -- -- P04323 1086 1.6e-116 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF04108//PF10044//PF05791//PF06009//PF04750//PF01105//PF08651 Autophagy protein Apg17//Retinal tissue protein//Bacillus haemolytic enterotoxin (HBL)//Laminin Domain II//FAR-17a/AIG1-like protein//emp24/gp25L/p24 family/GOLD//DASH complex subunit Duo1 GO:0006810//GO:0006914//GO:0009405//GO:0006351//GO:0007049//GO:0007155//GO:0007067 transport//autophagy//pathogenesis//transcription, DNA-templated//cell cycle//cell adhesion//mitotic nuclear division -- -- GO:0072686//GO:0016021//GO:0070176//GO:0016020//GO:0042729 mitotic spindle//integral component of membrane//DRM complex//membrane//DASH complex -- -- Cluster-8309.24571 BF_2 171.62 2.11 3697 478255182 ENN75411.1 3024 0.0e+00 hypothetical protein YQE_07962, partial [Dendroctonus ponderosae]>gi|546672240|gb|ERL84192.1| hypothetical protein D910_01568 [Dendroctonus ponderosae]>gi|546682608|gb|ERL92525.1| hypothetical protein D910_09838 [Dendroctonus ponderosae] -- -- -- -- -- K18727 TNPO2 transportin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K18727 Q99LG2 1567 2.0e-172 Transportin-2 OS=Mus musculus GN=Tnpo2 PE=2 SV=1 PF00514//PF07571//PF03810//PF02985 Armadillo/beta-catenin-like repeat//TAF6 C-terminal HEAT repeat domain//Importin-beta N-terminal domain//HEAT repeat GO:0051090//GO:0006886 regulation of sequence-specific DNA binding transcription factor activity//intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding GO:0005634 nucleus KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.24572 BF_2 243.48 5.19 2250 91084649 XP_966904.1 1039 4.9e-110 PREDICTED: spermidine synthase [Tribolium castaneum]>gi|270008634|gb|EFA05082.1| hypothetical protein TcasGA2_TC015179 [Tribolium castaneum] -- -- -- -- -- K00797 speE, SRM spermidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00797 Q64674 898 4.5e-95 Spermidine synthase OS=Mus musculus GN=Srm PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0016740 transferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.24573 BF_2 53.36 1.67 1622 642916569 XP_008191733.1 301 1.3e-24 PREDICTED: uncharacterized protein LOC103312564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24574 BF_2 13.92 0.34 1984 642916569 XP_008191733.1 301 1.6e-24 PREDICTED: uncharacterized protein LOC103312564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24580 BF_2 3.00 0.36 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24581 BF_2 232.00 24.64 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24583 BF_2 176.00 6.15 1484 91089517 XP_970614.1 942 5.7e-99 PREDICTED: thioredoxin domain-containing protein 9 [Tribolium castaneum]>gi|270011387|gb|EFA07835.1| hypothetical protein TcasGA2_TC005404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14530 549 8.7e-55 Thioredoxin domain-containing protein 9 OS=Homo sapiens GN=TXNDC9 PE=1 SV=2 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG1672 ATP binding protein Cluster-8309.24586 BF_2 9.00 2.72 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03324 Herpesvirus DNA helicase/primase complex associated protein GO:0019079 viral genome replication -- -- -- -- -- -- Cluster-8309.24588 BF_2 567.34 4.47 5596 642933274 XP_008197353.1 2916 0.0e+00 PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 [Tribolium castaneum] 850480667 CP011888.1 37 6.88593e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 1635 3.9e-180 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF01612//PF03798//PF00443//PF09061 3'-5' exonuclease//TLC domain//Ubiquitin carboxyl-terminal hydrolase//Stirrup GO:0016579//GO:0006139 protein deubiquitination//nucleobase-containing compound metabolic process GO:0003676//GO:0008408//GO:0016788//GO:0036459 nucleic acid binding//3'-5' exonuclease activity//hydrolase activity, acting on ester bonds//ubiquitinyl hydrolase activity GO:0016021 integral component of membrane KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.24589 BF_2 73.07 0.88 3762 478251138 ENN71614.1 1171 4.0e-125 hypothetical protein YQE_11713, partial [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q91XA9 609 2.4e-61 Acidic mammalian chitinase OS=Mus musculus GN=Chia PE=1 SV=2 PF00704//PF00839 Glycosyl hydrolases family 18//Cysteine rich repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016020 membrane -- -- Cluster-8309.24591 BF_2 428.08 11.37 1862 91079416 XP_967408.1 1829 1.0e-201 PREDICTED: microspherule protein 1 isoform X1 [Tribolium castaneum]>gi|270004380|gb|EFA00828.1| hypothetical protein TcasGA2_TC003716 [Tribolium castaneum] -- -- -- -- -- K11674 MCRS1, INO80Q microspherule protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11674 Q99L90 1057 1.4e-113 Microspherule protein 1 OS=Mus musculus GN=Mcrs1 PE=1 SV=1 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- KOG2293 Daxx-interacting protein MSP58/p78, contains FHA domain Cluster-8309.24595 BF_2 610.00 37.21 973 91095221 XP_969957.1 950 4.4e-100 PREDICTED: peptidyl-prolyl cis-trans isomerase H [Tribolium castaneum]>gi|270016016|gb|EFA12464.1| hypothetical protein TcasGA2_TC010612 [Tribolium castaneum] 242004769 XM_002423206.1 262 9.75024e-133 Pediculus humanus corporis peptidyl-prolyl cis-trans isomerase H, putative, mRNA K09567 PPIH, CYPH peptidyl-prolyl isomerase H (cyclophilin H) http://www.genome.jp/dbget-bin/www_bget?ko:K09567 O43447 770 1.3e-80 Peptidyl-prolyl cis-trans isomerase H OS=Homo sapiens GN=PPIH PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0879 U-snRNP-associated cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.24596 BF_2 4.00 0.51 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24598 BF_2 63.40 1.78 1775 189238236 XP_972123.2 372 8.4e-33 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Tribolium castaneum]>gi|270008671|gb|EFA05119.1| hypothetical protein TcasGA2_TC015232 [Tribolium castaneum] 743280388 KM065747.1 140 1.19176e-64 Culex quinquefasciatus clone C2B G-protein gamma-subunit mRNA, complete cds K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ3 335 6.8e-30 Guanine nucleotide-binding protein subunit gamma-e OS=Drosophila melanogaster GN=Ggamma30A PE=1 SV=1 PF00631//PF02501 GGL domain//Type II secretion system (T2SS), protein I GO:0015031//GO:0015628//GO:0007186//GO:0007165 protein transport//protein secretion by the type II secretion system//G-protein coupled receptor signaling pathway//signal transduction GO:0008565//GO:0004871 protein transporter activity//signal transducer activity GO:0015627//GO:0005834 type II protein secretion system complex//heterotrimeric G-protein complex KOG4119 G protein gamma subunit Cluster-8309.24603 BF_2 657.87 10.33 2950 91076316 XP_969753.1 1900 9.2e-210 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 O75191 1384 2.6e-151 Xylulose kinase OS=Homo sapiens GN=XYLB PE=1 SV=3 PF00370//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.24605 BF_2 215.00 3.43 2906 642935278 XP_008197945.1 2812 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase 4 [Tribolium castaneum] -- -- -- -- -- K12353 SMPD4 sphingomyelin phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12353 Q5XHG1 708 6.2e-73 Sphingomyelin phosphodiesterase 4 OS=Xenopus laevis GN=smpd4 PE=2 SV=2 PF14724 Mitochondrial-associated sphingomyelin phosphodiesterase GO:0006687 glycosphingolipid metabolic process GO:0050290 sphingomyelin phosphodiesterase D activity -- -- -- -- Cluster-8309.24606 BF_2 22.00 2.30 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24608 BF_2 5.77 1.31 471 332376935 AEE63607.1 134 8.8e-06 unknown [Dendroctonus ponderosae]>gi|478259710|gb|ENN79554.1| hypothetical protein YQE_04016, partial [Dendroctonus ponderosae]>gi|546676265|gb|ERL87311.1| hypothetical protein D910_04706 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24609 BF_2 585.58 13.90 2049 646717950 KDR20605.1 2455 2.8e-274 Elongator complex protein 3 [Zootermopsis nevadensis] 766940529 XM_011504565.1 409 0 PREDICTED: Ceratosolen solmsi marchali probable elongator complex protein 3 (LOC105366209), transcript variant X1, mRNA K07739 ELP3, KAT9 elongator complex protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07739 Q9VQZ6 2407 4.3e-270 Probable elongator complex protein 3 OS=Drosophila melanogaster GN=Elp3 PE=2 SV=1 PF13508//PF00583//PF04055 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Radical SAM superfamily GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0051536//GO:0003824 N-acetyltransferase activity//iron-sulfur cluster binding//catalytic activity -- -- KOG2535 RNA polymerase II elongator complex, subunit ELP3/histone acetyltransferase Cluster-8309.24614 BF_2 141.66 6.60 1185 817052027 XP_012254097.1 381 5.1e-34 PREDICTED: coiled-coil domain-containing protein 12 [Athalia rosae] -- -- -- -- -- K12871 CCDC12 coiled-coil domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12871 Q8WUD4 288 1.3e-24 Coiled-coil domain-containing protein 12 OS=Homo sapiens GN=CCDC12 PE=1 SV=1 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0000166//GO:0004814 ATP binding//nucleotide binding//arginine-tRNA ligase activity GO:0005737 cytoplasm KOG3407 Uncharacterized conserved protein Cluster-8309.24616 BF_2 18.59 0.55 1709 91079360 XP_970234.1 1401 3.9e-152 PREDICTED: armadillo repeat-containing protein 8 [Tribolium castaneum]>gi|270004363|gb|EFA00811.1| hypothetical protein TcasGA2_TC003698 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBR3 967 3.4e-103 Armadillo repeat-containing protein 8 OS=Mus musculus GN=Armc8 PE=2 SV=2 PF02985//PF01602//PF00514 HEAT repeat//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat -- -- Cluster-8309.24618 BF_2 17.40 0.62 1461 642914466 XP_008201689.1 1114 6.3e-119 PREDICTED: uncharacterized protein LOC100142496 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24624 BF_2 565.99 6.03 4216 91083325 XP_974870.1 5054 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB1 [Tribolium castaneum] 749796549 XM_011153388.1 449 0 PREDICTED: Harpegnathos saltator E3 ubiquitin-protein ligase MIB1 (LOC105190589), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q86YT6 3873 0.0e+00 E3 ubiquitin-protein ligase MIB1 OS=Homo sapiens GN=MIB1 PE=1 SV=1 PF13639//PF06701//PF00023//PF07664//PF00569//PF00097//PF14634//PF13606 Ring finger domain//Mib_herc2//Ankyrin repeat//Ferrous iron transport protein B C terminus//Zinc finger, ZZ type//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ankyrin repeat GO:0016567//GO:0015684 protein ubiquitination//ferrous iron transport GO:0005515//GO:0004842//GO:0015093//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//ferrous iron transmembrane transporter activity//metal ion binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.24625 BF_2 89.87 1.67 2532 390198530 AFL70632.1 2679 3.7e-300 putative hypoxia-inducible factor 1 beta [Callosobruchus maculatus] 820805517 KP147913.1 493 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1779 3.5e-197 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.24630 BF_2 49.21 0.78 2923 270015294 EFA11742.1 905 2.2e-94 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06350//PF11435 Hormone-sensitive lipase (HSL) N-terminus//RNA binding protein She2p GO:0016042//GO:0008203 lipid catabolic process//cholesterol metabolic process GO:0016298//GO:0003723 lipase activity//RNA binding -- -- -- -- Cluster-8309.24631 BF_2 0.79 1.27 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24634 BF_2 173.54 2.02 3887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- -- -- Cluster-8309.24635 BF_2 153.80 1.97 3555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- -- -- Cluster-8309.24636 BF_2 147.65 1.98 3408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- -- -- Cluster-8309.24637 BF_2 33.00 1.46 1232 233957366 ACQ91223.1 1752 5.6e-193 ribosomal protein L3 [Penaeus monodon] 699671850 XM_009902564.1 288 4.37509e-147 PREDICTED: Picoides pubescens ribosomal protein L3 (RPL3), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 1636 6.5e-181 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.24639 BF_2 30.00 0.67 2154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24643 BF_2 139.04 0.88 6904 642923353 XP_008193715.1 2309 8.1e-257 PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q80VJ4 828 1.8e-86 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Rattus norvegicus GN=Gpcpd1 PE=2 SV=1 PF03009//PF00686 Glycerophosphoryl diester phosphodiesterase family//Starch binding domain GO:0006629 lipid metabolic process GO:0008081//GO:2001070 phosphoric diester hydrolase activity//starch binding -- -- KOG2421 Predicted starch-binding protein Cluster-8309.24645 BF_2 20.00 0.56 1772 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24647 BF_2 12.84 0.71 1045 332376342 AEE63311.1 757 1.1e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01443 nagA, AMDHD2 N-acetylglucosamine-6-phosphate deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K01443 Q9VR81 709 1.7e-73 Putative N-acetylglucosamine-6-phosphate deacetylase OS=Drosophila melanogaster GN=CG17065 PE=2 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3892 N-acetyl-glucosamine-6-phosphate deacetylase Cluster-8309.24648 BF_2 58.43 1.78 1658 642916321 XP_008190972.1 316 2.5e-26 PREDICTED: uncharacterized protein LOC103312341 [Tribolium castaneum] 642916320 XM_008192750.1 163 1.82108e-77 PREDICTED: Tribolium castaneum uncharacterized LOC103312341 (LOC103312341), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24649 BF_2 15.86 0.55 1494 571330980 AHF27422.1 279 4.3e-22 putative sugar transporter 16 [Phaedon cochleariae] 642916327 XM_008192753.1 93 1.33922e-38 PREDICTED: Tribolium castaneum glucose transporter type 1 (LOC663886), transcript variant X2, mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 Q8IRI6 237 1.3e-18 Glucose transporter type 1 OS=Drosophila melanogaster GN=Glut1 PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24652 BF_2 80.21 1.02 3578 642927427 XP_008195268.1 1097 1.5e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF16622 Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.24653 BF_2 96.79 2.19 2137 270006196 EFA02644.1 460 6.3e-43 hypothetical protein TcasGA2_TC008365 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24654 BF_2 42.32 0.67 2930 91081873 XP_968521.1 958 1.6e-100 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 2.73179e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF00612//PF05531 IQ calmodulin-binding motif//Nucleopolyhedrovirus P10 protein -- -- GO:0005515 protein binding GO:0019028 viral capsid -- -- Cluster-8309.24655 BF_2 316.75 8.92 1772 642939029 XP_008200194.1 621 1.1e-61 PREDICTED: uncharacterized protein LOC103314860 [Tribolium castaneum]>gi|270016275|gb|EFA12721.1| hypothetical protein TcasGA2_TC002356 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D722 128 6.8e-06 Oxidative stress-responsive serine-rich protein 1 OS=Mus musculus GN=Oser1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24657 BF_2 248.36 4.73 2483 195126088 XP_002007506.1 1447 2.6e-157 GI12352 [Drosophila mojavensis]>gi|193919115|gb|EDW17982.1| GI12352 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- P51523 666 3.9e-68 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF05645//PF13912//PF13465//PF00096 RNA polymerase III subunit RPC82//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0005488//GO:0046872//GO:0003899//GO:0003677 binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.24660 BF_2 601.88 4.31 6134 189242026 XP_968092.2 2096 3.6e-232 PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938706|ref|XP_008196798.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938708|ref|XP_008196803.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938710|ref|XP_008196809.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938712|ref|XP_008196813.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938715|ref|XP_008196822.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|270015800|gb|EFA12248.1| hypothetical protein TcasGA2_TC016108 [Tribolium castaneum] 675175042 XM_008898158.1 35 9.76943e-06 Phytophthora parasitica INRA-310 hypothetical protein mRNA -- -- -- -- Q96NB2 1019 1.1e-108 Sideroflexin-2 OS=Homo sapiens GN=SFXN2 PE=1 SV=2 PF03820 Tricarboxylate carrier GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.24661 BF_2 235.13 1.55 6621 642931369 XP_008196550.1 7264 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931364 XM_008198326.1 1384 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X4, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q7PHR1 5861 0.0e+00 Kinesin-like protein unc-104 OS=Anopheles gambiae GN=unc-104 PE=3 SV=3 PF00225//PF06414//PF10390//PF00498//PF00959//PF07353//PF05171//PF05014 Kinesin motor domain//Zeta toxin//RNA polymerase II elongation factor ELL//FHA domain//Phage lysozyme//Uroplakin II//Haemin-degrading HemS.ChuX domain//Nucleoside 2-deoxyribosyltransferase GO:0006368//GO:0016998//GO:0006206//GO:0007018//GO:0009159//GO:0009253//GO:0061024//GO:0007017//GO:0005975//GO:0006826 transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//pyrimidine nucleobase metabolic process//microtubule-based movement//deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process//membrane organization//microtubule-based process//carbohydrate metabolic process//iron ion transport GO:0003777//GO:0005515//GO:0003796//GO:0070694//GO:0008017//GO:0005524//GO:0050144//GO:0016301 microtubule motor activity//protein binding//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule binding//ATP binding//nucleoside deoxyribosyltransferase activity//kinase activity GO:0030176//GO:0008023//GO:0005874//GO:0045298 integral component of endoplasmic reticulum membrane//transcription elongation factor complex//microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.24662 BF_2 11.00 1.35 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05112 Baculovirus P47 protein GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.24663 BF_2 1350.30 24.53 2590 282158099 NP_001164093.1 2349 7.0e-262 SNF1A/AMP-activated protein kinase [Tribolium castaneum]>gi|270010962|gb|EFA07410.1| SNF1A/AMP-activated protein kinase [Tribolium castaneum] 815926247 XM_012392281.1 380 0 PREDICTED: Bombus impatiens 5'-AMP-activated protein kinase catalytic subunit alpha-2 (LOC100744469), transcript variant X4, mRNA K07198 PRKAA, AMPK 5'-AMP-activated protein kinase, catalytic alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07198 Q28948 1757 1.3e-194 5'-AMP-activated protein kinase catalytic subunit alpha-2 OS=Sus scrofa GN=PRKAA2 PE=2 SV=2 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-8309.24669 BF_2 418.00 20.48 1141 91079008 XP_974790.1 790 1.8e-81 PREDICTED: ubiquitin-conjugating enzyme E2 W [Tribolium castaneum]>gi|642916289|ref|XP_008190962.1| PREDICTED: ubiquitin-conjugating enzyme E2 W [Tribolium castaneum]>gi|270003673|gb|EFA00121.1| hypothetical protein TcasGA2_TC002937 [Tribolium castaneum] 642916290 XM_969697.2 241 5.42417e-121 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2 W (LOC663661), transcript variant X2, mRNA K10688 UBE2W, UBC16 ubiquitin-conjugating enzyme E2 W http://www.genome.jp/dbget-bin/www_bget?ko:K10688 Q28FC1 646 3.8e-66 Ubiquitin-conjugating enzyme E2 W OS=Xenopus tropicalis GN=ube2w PE=2 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0016881//GO:0005515 acid-amino acid ligase activity//protein binding -- -- KOG0427 Ubiquitin conjugating enzyme Cluster-8309.24671 BF_2 36.75 3.16 773 642927957 XP_008195462.1 274 8.5e-22 PREDICTED: transcriptional adapter 2B [Tribolium castaneum]>gi|270009831|gb|EFA06279.1| hypothetical protein TcasGA2_TC009145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04433 SWIRM domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.24673 BF_2 288.02 5.79 2369 91093989 XP_970414.1 1011 9.0e-107 PREDICTED: golgin-45 [Tribolium castaneum]>gi|270016104|gb|EFA12552.1| hypothetical protein TcasGA2_TC001960 [Tribolium castaneum] 801398575 XM_012204360.1 66 2.18834e-23 PREDICTED: Atta cephalotes uncharacterized LOC105622954 (LOC105622954), mRNA -- -- -- -- Q9H2G9 263 2.0e-21 Golgin-45 OS=Homo sapiens GN=BLZF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4074 Leucine zipper nuclear factor Cluster-8309.24681 BF_2 419.16 6.81 2861 91088445 XP_968690.1 1260 1.5e-135 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 857 3.2e-90 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF07497//PF00515//PF13371//PF04658//PF13176//PF00520//PF13414//PF13181//PF04564//PF02465 Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TAFII55 protein conserved region//Tetratricopeptide repeat//Ion transport protein//TPR repeat//Tetratricopeptide repeat//U-box domain//Flagellar hook-associated protein 2 N-terminus GO:0055085//GO:0016567//GO:0006353//GO:0006367//GO:0006811 transmembrane transport//protein ubiquitination//DNA-templated transcription, termination//transcription initiation from RNA polymerase II promoter//ion transport GO:0003723//GO:0004842//GO:0005515//GO:0005216 RNA binding//ubiquitin-protein transferase activity//protein binding//ion channel activity GO:0000151//GO:0016020//GO:0009424//GO:0005669 ubiquitin ligase complex//membrane//bacterial-type flagellum hook//transcription factor TFIID complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.24683 BF_2 177.76 1.58 5003 642919183 XP_008191772.1 3011 0.0e+00 PREDICTED: uncharacterized protein LOC103312580 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24685 BF_2 165.00 7.27 1236 270011155 EFA07603.1 173 7.0e-10 gustatory receptor 106 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.24686 BF_2 61.12 3.45 1029 225543108 NP_001139415.1 219 2.7e-15 sex lethal [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.24688 BF_2 577.88 12.33 2248 91077894 XP_973141.1 1322 7.4e-143 PREDICTED: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [Tribolium castaneum]>gi|270001465|gb|EEZ97912.1| hypothetical protein TcasGA2_TC000297 [Tribolium castaneum] 704568790 XM_010186488.1 35 3.5465e-06 PREDICTED: Mesitornis unicolor farnesyltransferase, CAAX box, alpha (FNTA), partial mRNA K05955 FNTA protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05955 P29702 867 1.8e-91 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Bos taurus GN=FNTA PE=2 SV=2 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- KOG0530 Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit Cluster-8309.24692 BF_2 215.20 5.03 2078 642938569 XP_968860.2 1706 2.0e-187 PREDICTED: ceramide glucosyltransferase-B [Tribolium castaneum] -- -- -- -- -- K00720 UGCG ceramide glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00720 Q16739 1082 1.9e-116 Ceramide glucosyltransferase OS=Homo sapiens GN=UGCG PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2547 Ceramide glucosyltransferase Cluster-8309.24696 BF_2 793.00 21.34 1842 189237781 XP_972376.2 1047 4.7e-111 PREDICTED: ras-related and estrogen-regulated growth inhibitor-like protein [Tribolium castaneum]>gi|270006779|gb|EFA03227.1| hypothetical protein TcasGA2_TC013156 [Tribolium castaneum] -- -- -- -- -- K17198 RERGL Ras-related and estrogen-regulated growth inhibitor-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17198 Q6DGN0 351 9.8e-32 Ras-related and estrogen-regulated growth inhibitor-like protein OS=Danio rerio GN=rergl PE=2 SV=1 PF01926//PF08477//PF03193//PF00071//PF00025 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ras family//ADP-ribosylation factor family GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.24699 BF_2 153.00 8.34 1055 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16818 Protein SLM4 GO:0016237//GO:0007165 lysosomal microautophagy//signal transduction -- -- GO:0034448 EGO complex -- -- Cluster-8309.24702 BF_2 97.00 1.66 2738 546677053 ERL87962.1 2168 7.2e-241 hypothetical protein D910_05350 [Dendroctonus ponderosae] 734644669 XM_010753083.1 119 8.73021e-53 PREDICTED: Larimichthys crocea frizzled-7-A-like (LOC104936971), mRNA K02432 FZD1_7, fz frizzled 1/7 http://www.genome.jp/dbget-bin/www_bget?ko:K02432 Q9I9M5 1670 1.6e-184 Frizzled-1 OS=Xenopus laevis GN=fzd1 PE=2 SV=1 PF01392//PF01534//PF05923 Fz domain//Frizzled/Smoothened family membrane region//APC cysteine-rich region GO:0007166//GO:0016055 cell surface receptor signaling pathway//Wnt signaling pathway GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.24704 BF_2 1047.31 8.29 5571 189241139 XP_973746.2 1033 6.0e-109 PREDICTED: mitoferrin-1 [Tribolium castaneum] -- -- -- -- -- K15113 SLC25A28_37, MFRN solute carrier family 25 (mitochondrial iron transporter), member 28/37 http://www.genome.jp/dbget-bin/www_bget?ko:K15113 Q9VAY3 718 8.2e-74 Mitoferrin OS=Drosophila melanogaster GN=mfrn PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0760 Mitochondrial carrier protein MRS3/4 Cluster-8309.24705 BF_2 45.46 0.68 3103 189234994 XP_969025.2 1345 2.2e-145 PREDICTED: protein SMG7-like [Tribolium castaneum] -- -- -- -- -- K14409 SMG7, EST1C protein SMG7 http://www.genome.jp/dbget-bin/www_bget?ko:K14409 Q92540 346 6.3e-31 Protein SMG7 OS=Homo sapiens GN=SMG7 PE=1 SV=2 PF13176//PF07776 Tetratricopeptide repeat//Zinc-finger associated domain (zf-AD) -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.24706 BF_2 26.48 0.38 3175 300394168 ADK11710.1 671 3.2e-67 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q32LQ0 512 3.6e-50 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.24708 BF_2 185.61 0.70 11411 642929737 XP_008195956.1 3594 0.0e+00 PREDICTED: zinc finger SWIM domain-containing protein 6-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P217 2085 5.2e-232 Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 PF04851//PF02892//PF02724//PF02861//PF00570//PF01189//PF00270//PF05063//PF09382 Type III restriction enzyme, res subunit//BED zinc finger//CDC45-like protein//Clp amino terminal domain, pathogenicity island component//HRDC domain//16S rRNA methyltransferase RsmF//DEAD/DEAH box helicase//MT-A70//RQC domain GO:0006270//GO:0006139//GO:0006281//GO:0019538//GO:0006260 DNA replication initiation//nucleobase-containing compound metabolic process//DNA repair//protein metabolic process//DNA replication GO:0005524//GO:0003677//GO:0016787//GO:0043140//GO:0008168//GO:0003676 ATP binding//DNA binding//hydrolase activity//ATP-dependent 3'-5' DNA helicase activity//methyltransferase activity//nucleic acid binding GO:0005657//GO:0005622 replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.24712 BF_2 114.77 5.11 1226 478250773 ENN71265.1 427 2.4e-39 hypothetical protein YQE_12191, partial [Dendroctonus ponderosae]>gi|546673029|gb|ERL84715.1| hypothetical protein D910_02140 [Dendroctonus ponderosae] -- -- -- -- -- K14294 WIBG, PYM partner of Y14 and mago http://www.genome.jp/dbget-bin/www_bget?ko:K14294 Q2F5J3 285 2.9e-24 Partner of Y14 and mago OS=Bombyx mori GN=wibg PE=2 SV=1 PF07966//PF09317//PF09268 A1 Propeptide//Domain of unknown function (DUF1974)//Clathrin, heavy-chain linker GO:0006118//GO:0006508//GO:0055114//GO:0033539//GO:0016192//GO:0006886 obsolete electron transport//proteolysis//oxidation-reduction process//fatty acid beta-oxidation using acyl-CoA dehydrogenase//vesicle-mediated transport//intracellular protein transport GO:0003995//GO:0004190//GO:0005198 acyl-CoA dehydrogenase activity//aspartic-type endopeptidase activity//structural molecule activity GO:0030130//GO:0030132 clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit KOG4325 Uncharacterized conserved protein Cluster-8309.24713 BF_2 636.00 25.91 1314 91076078 XP_967638.1 641 4.0e-64 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|642911608|ref|XP_008200670.1| PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|642911610|ref|XP_008200671.1| PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|642911612|ref|XP_008200672.1| PREDICTED: gamma-interferon-inducible lysosomal thiol reductase [Tribolium castaneum]>gi|270014694|gb|EFA11142.1| hypothetical protein TcasGA2_TC004743 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QPN6 237 1.2e-18 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.24714 BF_2 157.38 5.48 1489 642917191 XP_975978.2 154 1.3e-07 PREDICTED: active regulator of SIRT1-like [Tribolium castaneum]>gi|270004376|gb|EFA00824.1| hypothetical protein TcasGA2_TC003712 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529//PF00665 DHHC palmitoyltransferase//Integrase core domain GO:0015074 DNA integration GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.24717 BF_2 35.03 0.50 3226 270002464 EEZ98911.1 1451 1.2e-157 hypothetical protein TcasGA2_TC004530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60299 397 8.0e-37 Leucine zipper putative tumor suppressor 3 OS=Homo sapiens GN=LZTS3 PE=2 SV=1 PF00769//PF10288//PF01008 Ezrin/radixin/moesin family//Cytoplasmic tRNA 2-thiolation protein 2//Initiation factor 2 subunit family GO:0034227//GO:0002098//GO:0044237 tRNA thio-modification//tRNA wobble uridine modification//cellular metabolic process GO:0008092//GO:0000049 cytoskeletal protein binding//tRNA binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm -- -- Cluster-8309.24719 BF_2 554.07 6.43 3891 506969311 AGM32999.1 970 8.4e-102 thioredoxin domain-containing protein, partial [Coptotermes formosanus] -- -- -- -- -- K02606 ORC4 origin recognition complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02606 O43929 581 4.4e-58 Origin recognition complex subunit 4 OS=Homo sapiens GN=ORC4 PE=1 SV=2 PF04517//PF05496//PF00437//PF00448//PF00005//PF13676//PF03266//PF03193//PF01637//PF07728//PF00085//PF00004//PF03205//PF02367//PF00503//PF00931//PF00578 Microvirus lysis protein (E), C terminus//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//ABC transporter//TIR domain//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//AAA domain (dynein-related subfamily)//Thioredoxin//ATPase family associated with various cellular activities (AAA)//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//G-protein alpha subunit//NB-ARC domain//AhpC/TSA family GO:0055114//GO:0007186//GO:0006777//GO:0006281//GO:0006810//GO:0006614//GO:0007165//GO:0045454//GO:0006310//GO:0002949//GO:0019054 oxidation-reduction process//G-protein coupled receptor signaling pathway//Mo-molybdopterin cofactor biosynthetic process//DNA repair//transport//SRP-dependent cotranslational protein targeting to membrane//signal transduction//cell redox homeostasis//DNA recombination//tRNA threonylcarbamoyladenosine modification//modulation by virus of host process GO:0019001//GO:0016209//GO:0016887//GO:0003924//GO:0005524//GO:0098519//GO:0031683//GO:0009378//GO:0005525//GO:0004871//GO:0004857//GO:0043531//GO:0005515//GO:0016491 guanyl nucleotide binding//antioxidant activity//ATPase activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//G-protein beta/gamma-subunit complex binding//four-way junction helicase activity//GTP binding//signal transducer activity//enzyme inhibitor activity//ADP binding//protein binding//oxidoreductase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG2228 Origin recognition complex, subunit 4 Cluster-8309.24724 BF_2 184.00 5.29 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24727 BF_2 42.53 1.44 1521 780616929 XP_011698547.1 138 9.8e-06 PREDICTED: zinc finger BED domain-containing protein RICESLEEPER 2-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24731 BF_2 1815.59 54.26 1687 642931134 XP_008196457.1 1421 1.8e-154 PREDICTED: yellow-e3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17060 491 5.2e-48 Major royal jelly protein 3 OS=Apis mellifera GN=MRJP3 PE=1 SV=1 PF02978 Signal peptide binding domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500 signal recognition particle -- -- Cluster-8309.24733 BF_2 100.05 2.88 1740 531443907 AGT57833.1 1731 2.1e-190 cytochrome P450 306a1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K10720 PHM CYP306A1; ecdysteroid 25-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10720 Q9VWR5 907 3.1e-96 Cytochrome P450 306a1 OS=Drosophila melanogaster GN=phm PE=1 SV=1 PF00067//PF00407 Cytochrome P450//Pathogenesis-related protein Bet v I family GO:0055114//GO:0006952//GO:0009607 oxidation-reduction process//defense response//response to biotic stimulus GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.24734 BF_2 36.84 0.66 2610 642927837 XP_008195420.1 541 3.1e-52 PREDICTED: HSPB1-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q96EW2 249 9.3e-20 HSPB1-associated protein 1 OS=Homo sapiens GN=HSPBAP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.24736 BF_2 60.44 0.81 3403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24737 BF_2 47.31 0.94 2402 546678378 ERL89011.1 667 7.1e-67 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 497 1.5e-48 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3936 Nitroreductases Cluster-8309.24739 BF_2 20.00 1.77 760 270012421 EFA08869.1 260 3.5e-20 hypothetical protein TcasGA2_TC006570 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.24740 BF_2 57.00 2.78 1146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24743 BF_2 43.00 1.22 1760 642929939 XP_008196034.1 980 2.6e-103 PREDICTED: nucleolar protein 4-like isoform X2 [Tribolium castaneum] 642929940 XM_008197813.1 280 1.76546e-142 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X3, mRNA -- -- -- -- O94818 393 1.3e-36 Nucleolar protein 4 OS=Homo sapiens GN=NOL4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24744 BF_2 173.21 2.33 3395 642929937 XP_008196033.1 1684 1.2e-184 PREDICTED: nucleolar protein 4-like isoform X1 [Tribolium castaneum] 642929936 XM_008197811.1 374 0 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X1, mRNA -- -- -- -- Q96MY1 448 1.0e-42 Nucleolar protein 4-like OS=Homo sapiens GN=NOL4L PE=1 SV=2 PF09026//PF03607 Centromere protein B dimerisation domain//Doublecortin GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0003682 DNA binding//chromatin binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region -- -- Cluster-8309.24748 BF_2 32.32 0.76 2066 91088421 XP_967011.1 289 4.1e-23 PREDICTED: activated RNA polymerase II transcriptional coactivator p15 [Tribolium castaneum]>gi|270012200|gb|EFA08648.1| hypothetical protein TcasGA2_TC006312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11031 175 2.8e-11 Activated RNA polymerase II transcriptional coactivator p15 OS=Mus musculus GN=Sub1 PE=1 SV=3 PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003713//GO:0003677 transcription coactivator activity//DNA binding GO:0005667 transcription factor complex KOG2712 Transcriptional coactivator Cluster-8309.24751 BF_2 364.25 6.16 2760 91088433 XP_967839.1 919 4.9e-96 PREDICTED: BTB/POZ domain-containing protein KCTD5 [Tribolium castaneum]>gi|270012205|gb|EFA08653.1| hypothetical protein TcasGA2_TC006318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5PKG7 639 5.9e-65 BTB/POZ domain-containing protein KCTD5 OS=Bos taurus GN=KCTD5 PE=2 SV=1 PF02214//PF00651 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG2715 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.24752 BF_2 653.91 21.52 1558 91091360 XP_972551.1 1160 3.1e-124 PREDICTED: 26S protease regulatory subunit 8 [Tribolium castaneum] 242005916 XM_002423761.1 299 4.27294e-153 Pediculus humanus corporis 26S protease regulatory subunit, putative, mRNA K03066 PSMC5, RPT6 26S proteasome regulatory subunit T6 http://www.genome.jp/dbget-bin/www_bget?ko:K03066 O18413 1102 6.8e-119 26S protease regulatory subunit 8 OS=Drosophila melanogaster GN=Rpt6 PE=1 SV=2 PF00910//PF06414//PF02367//PF02562//PF07726//PF07724//PF00004//PF06009//PF06068//PF00158//PF05496//PF01057//PF07728//PF01383//PF01695 RNA helicase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Laminin Domain II//TIP49 C-terminus//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//Parvovirus non-structural protein NS1//AAA domain (dynein-related subfamily)//CpcD/allophycocyanin linker domain//IstB-like ATP binding protein GO:0006355//GO:0019079//GO:0006281//GO:0002949//GO:0007155//GO:0006310 regulation of transcription, DNA-templated//viral genome replication//DNA repair//tRNA threonylcarbamoyladenosine modification//cell adhesion//DNA recombination GO:0016301//GO:0016887//GO:0005524//GO:0008134//GO:0009378//GO:0003724//GO:0003678//GO:0003723 kinase activity//ATPase activity//ATP binding//transcription factor binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding GO:0030089//GO:0009379//GO:0005657//GO:0005667 phycobilisome//Holliday junction helicase complex//replication fork//transcription factor complex KOG0728 26S proteasome regulatory complex, ATPase RPT6 Cluster-8309.24754 BF_2 404.37 2.76 6405 546680884 ERL91070.1 2675 2.7e-299 hypothetical protein D910_08412 [Dendroctonus ponderosae] -- -- -- -- -- K11798 BRWD1_3 bromodomain and WD repeat domain containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11798 Q9NSI6 1521 7.3e-167 Bromodomain and WD repeat-containing protein 1 OS=Homo sapiens GN=BRWD1 PE=1 SV=4 PF13409//PF00400//PF10717//PF13417//PF02798//PF00439//PF06507 Glutathione S-transferase, N-terminal domain//WD domain, G-beta repeat//Occlusion-derived virus envelope protein ODV-E18//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Bromodomain//Auxin response factor GO:0009725//GO:0006355 response to hormone//regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634//GO:0019031 nucleus//viral envelope KOG0644 Uncharacterized conserved protein, contains WD40 repeat and BROMO domains Cluster-8309.24755 BF_2 35.14 1.51 1263 189239014 XP_974755.2 532 1.7e-51 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 212 8.8e-16 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24759 BF_2 13.00 2.33 520 188572397 ACD65105.1 459 2.0e-43 putative 40S ribosomal protein RPS20 [Novocrania anomala] 342356368 JF265012.1 80 7.52019e-32 Heliconius melpomene cythera ribosomal protein S20 (RpS20) mRNA, complete cds K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P23403 454 3.1e-44 40S ribosomal protein S20 OS=Xenopus laevis GN=rps20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.24762 BF_2 70.68 1.71 2015 449083364 NP_001263355.1 852 2.1e-88 dehydrogenase/reductase SDR family member 4 [Tribolium castaneum]>gi|270003836|gb|EFA00284.1| hypothetical protein TcasGA2_TC003117 [Tribolium castaneum] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 601 1.1e-60 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.24764 BF_2 672.90 8.94 3435 642928838 XP_008195583.1 3915 0.0e+00 PREDICTED: uncharacterized protein LOC656400 [Tribolium castaneum] 642928837 XM_008197361.1 741 0 PREDICTED: Tribolium castaneum uncharacterized LOC656400 (LOC656400), mRNA -- -- -- -- Q8NBH2 372 6.7e-34 Kyphoscoliosis peptidase OS=Homo sapiens GN=KY PE=1 SV=2 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.24765 BF_2 5.74 0.37 940 751224154 XP_011165403.1 664 6.2e-67 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24766 BF_2 158.08 9.02 1020 478250011 ENN70517.1 712 1.8e-72 hypothetical protein YQE_12693, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 333 6.6e-30 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF01318//PF07809 Bromovirus coat protein//RTP801 C-terminal region GO:0009968 negative regulation of signal transduction GO:0005198 structural molecule activity GO:0019028//GO:0005737 viral capsid//cytoplasm -- -- Cluster-8309.24767 BF_2 203.78 5.31 1894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24768 BF_2 284.75 3.52 3671 91084037 XP_966813.1 440 2.3e-40 PREDICTED: putative defense protein Hdd11 [Tribolium castaneum]>gi|642924804|ref|XP_008194048.1| PREDICTED: putative defense protein Hdd11 [Tribolium castaneum]>gi|270006698|gb|EFA03146.1| hypothetical protein TcasGA2_TC013059 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q008X1 248 1.7e-19 Putative defense protein OS=Bombyx mori PE=2 SV=1 PF00864 ATP P2X receptor GO:0006812//GO:0007165//GO:0098655//GO:0033198 cation transport//signal transduction//cation transmembrane transport//response to ATP GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.24771 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24774 BF_2 18.03 0.54 1696 642916998 XP_001812033.2 195 2.7e-12 PREDICTED: uncharacterized protein LOC100142249 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24775 BF_2 26.00 1.43 1049 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24776 BF_2 55.76 0.48 5113 642915698 XP_008190764.1 2683 2.6e-300 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X2 [Tribolium castaneum] 642915699 XM_008192543.1 222 9.06905e-110 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 7.8e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.24781 BF_2 48.86 0.41 5331 91081873 XP_968521.1 1429 6.9e-155 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 4.99822e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence K16717 CEP97 centrosomal protein CEP97 http://www.genome.jp/dbget-bin/www_bget?ko:K16717 Q8IW35 304 8.0e-26 Centrosomal protein of 97 kDa OS=Homo sapiens GN=CEP97 PE=1 SV=1 PF00560//PF00612//PF05531//PF13855 Leucine Rich Repeat//IQ calmodulin-binding motif//Nucleopolyhedrovirus P10 protein//Leucine rich repeat -- -- GO:0005515 protein binding GO:0019028 viral capsid -- -- Cluster-8309.24784 BF_2 3.00 0.49 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24787 BF_2 14.69 0.44 1680 332373512 AEE61897.1 845 1.1e-87 unknown [Dendroctonus ponderosae]>gi|478261742|gb|ENN80889.1| hypothetical protein YQE_02678, partial [Dendroctonus ponderosae]>gi|546674326|gb|ERL85730.1| hypothetical protein D910_03145 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 Q9VKH6 666 2.7e-68 Lysosomal thioesterase PPT2 homolog OS=Drosophila melanogaster GN=Ppt2 PE=2 SV=1 PF02089 Palmitoyl protein thioesterase -- -- GO:0098599 palmitoyl hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.24790 BF_2 354.06 3.55 4465 546686163 ERL95549.1 2201 1.7e-244 hypothetical protein D910_12810 [Dendroctonus ponderosae] -- -- -- -- -- K10273 FBXL7 F-box and leucine-rich repeat protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10273 Q5BJ29 991 1.5e-105 F-box/LRR-repeat protein 7 OS=Mus musculus GN=Fbxl7 PE=1 SV=1 PF00560//PF00481//PF00646//PF09029//PF15966//PF13516//PF12937 Leucine Rich Repeat//Protein phosphatase 2C//F-box domain//5-aminolevulinate synthase presequence//F-box//Leucine Rich repeat//F-box-like GO:0042967//GO:0006563//GO:0006544//GO:0006783//GO:0006778//GO:0006566 acyl-carrier-protein biosynthetic process//L-serine metabolic process//glycine metabolic process//heme biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process GO:0003870//GO:0005515//GO:0030170//GO:0003824 5-aminolevulinate synthase activity//protein binding//pyridoxal phosphate binding//catalytic activity GO:0005759 mitochondrial matrix KOG1323 Serine/threonine phosphatase Cluster-8309.24794 BF_2 107.16 0.72 6536 642938278 XP_008192712.1 3281 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 958 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.4e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF12142//PF00069//PF07714 Polyphenol oxidase middle domain//Protein kinase domain//Protein tyrosine kinase GO:0055114//GO:0006468//GO:0006570//GO:0006118 oxidation-reduction process//protein phosphorylation//tyrosine metabolic process//obsolete electron transport GO:0004097//GO:0004672//GO:0005524 catechol oxidase activity//protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.24795 BF_2 224.42 1.69 5837 642938278 XP_008192712.1 3480 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 1092 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 Q9UKI8 1880 1.6e-208 Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens GN=TLK1 PE=1 SV=2 PF12142//PF07714//PF00069 Polyphenol oxidase middle domain//Protein tyrosine kinase//Protein kinase domain GO:0006570//GO:0006468//GO:0055114//GO:0006118 tyrosine metabolic process//protein phosphorylation//oxidation-reduction process//obsolete electron transport GO:0004097//GO:0004672//GO:0005524 catechol oxidase activity//protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.24796 BF_2 90.43 0.57 6935 -- -- -- -- -- 642938285 XM_008194514.1 89 1.05885e-35 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF09477 Bacterial type II secretion system chaperone protein (type_III_yscG) GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.24807 BF_2 71.00 2.43 1507 478257104 ENN77267.1 658 4.9e-66 hypothetical protein YQE_06095, partial [Dendroctonus ponderosae]>gi|546683359|gb|ERL93181.1| hypothetical protein D910_10478 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 131 2.6e-06 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.24809 BF_2 72.10 1.37 2483 91076754 XP_973519.1 1358 5.5e-147 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63564 356 3.5e-32 Synaptic vesicle glycoprotein 2B OS=Rattus norvegicus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.24812 BF_2 11.00 0.53 1160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24813 BF_2 40.26 0.35 5134 478251476 ENN71939.1 1895 6.1e-209 hypothetical protein YQE_11373, partial [Dendroctonus ponderosae] 642917170 XM_966698.2 42 1.04907e-09 PREDICTED: Tribolium castaneum centrosomin (LOC660470), transcript variant X2, mRNA -- -- -- -- P54623 285 1.2e-23 Centrosomin OS=Drosophila melanogaster GN=cnn PE=1 SV=3 PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.24814 BF_2 551.60 4.84 5056 478251476 ENN71939.1 1947 5.6e-215 hypothetical protein YQE_11373, partial [Dendroctonus ponderosae] 642917170 XM_966698.2 42 1.03302e-09 PREDICTED: Tribolium castaneum centrosomin (LOC660470), transcript variant X2, mRNA -- -- -- -- P54623 285 1.2e-23 Centrosomin OS=Drosophila melanogaster GN=cnn PE=1 SV=3 PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.24815 BF_2 154.00 12.27 812 91087357 XP_975625.1 881 3.7e-92 PREDICTED: ADP-ribosylation factor-like protein 2 [Tribolium castaneum]>gi|270010616|gb|EFA07064.1| hypothetical protein TcasGA2_TC010041 [Tribolium castaneum] -- -- -- -- -- K07943 ARL2 ADP-ribosylation factor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07943 P36404 783 3.5e-82 ADP-ribosylation factor-like protein 2 OS=Homo sapiens GN=ARL2 PE=1 SV=4 PF00503//PF04670//PF00025//PF00071//PF08477//PF01926 G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0019001//GO:0004871//GO:0005525//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//GTP binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0005622 intracellular KOG0073 GTP-binding ADP-ribosylation factor-like protein ARL2 Cluster-8309.24816 BF_2 3605.00 82.28 2120 91078182 XP_967647.1 1947 2.4e-215 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IW92 1064 2.4e-114 Beta-galactosidase-1-like protein 2 OS=Homo sapiens GN=GLB1L2 PE=2 SV=1 PF02449//PF05924 Beta-galactosidase//SAMP Motif GO:0046486//GO:0005975//GO:0006687//GO:0008152//GO:0006012//GO:0016055//GO:0006027 glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//metabolic process//galactose metabolic process//Wnt signaling pathway//glycosaminoglycan catabolic process GO:0008013//GO:0004565//GO:0004553 beta-catenin binding//beta-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016342//GO:0009341 catenin complex//beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.24820 BF_2 4.87 12.59 275 478250401 ENN70896.1 215 2.1e-15 hypothetical protein YQE_12301, partial [Dendroctonus ponderosae]>gi|546672892|gb|ERL84615.1| hypothetical protein D910_02043 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24821 BF_2 667.93 24.15 1444 91079768 XP_966889.1 821 5.9e-85 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 310 4.4e-27 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166//GO:0003824//GO:0050662 oxidoreductase activity//nucleotide binding//catalytic activity//coenzyme binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.24826 BF_2 35.46 0.55 2972 91082057 XP_971798.1 1924 1.5e-212 PREDICTED: mitochondrial chaperone BCS1 [Tribolium castaneum]>gi|270007281|gb|EFA03729.1| hypothetical protein TcasGA2_TC013838 [Tribolium castaneum] 815794844 XM_012362642.1 161 4.26014e-76 PREDICTED: Linepithema humile mitochondrial chaperone BCS1 (LOC105669594), mRNA K08900 BCS1 mitochondrial chaperone BCS1 http://www.genome.jp/dbget-bin/www_bget?ko:K08900 Q7ZV60 1367 2.4e-149 Mitochondrial chaperone BCS1 OS=Danio rerio GN=bcs1l PE=2 SV=2 PF06431//PF00910//PF00004//PF07728//PF00005 Polyomavirus large T antigen C-terminus//RNA helicase//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//ABC transporter GO:0006260 DNA replication GO:0003724//GO:0017111//GO:0016887//GO:0003677//GO:0003723//GO:0005524 RNA helicase activity//nucleoside-triphosphatase activity//ATPase activity//DNA binding//RNA binding//ATP binding -- -- KOG0743 AAA+-type ATPase Cluster-8309.24828 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24829 BF_2 4.00 5.97 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24830 BF_2 2.00 5.31 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF12356//PF04506//PF06784 Zinc-finger associated domain (zf-AD)//Protein of unknown function (DUF3643)//Rft protein//Uncharacterised protein family (UPF0240) GO:0006869//GO:0032465//GO:0016567//GO:0006915//GO:0032981 lipid transport//regulation of cytokinesis//protein ubiquitination//apoptotic process//mitochondrial respiratory chain complex I assembly GO:0005319//GO:0004842//GO:0008270 lipid transporter activity//ubiquitin-protein transferase activity//zinc ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.24833 BF_2 343.64 3.06 4979 546678097 ERL88806.1 2073 1.4e-229 hypothetical protein D910_06188 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.24836 BF_2 92.93 1.50 2887 642917459 XP_008191209.1 2783 0.0e+00 PREDICTED: ral guanine nucleotide dissociation stimulator-like 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17635 RGL1, RGL ral guanine nucleotide dissociation stimulator-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17635 Q9NZL6 962 2.2e-102 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00617//PF04604//PF00788 RasGEF domain//Type-A lantibiotic//Ras association (RalGDS/AF-6) domain GO:0007264//GO:0043087//GO:0042742//GO:0007165 small GTPase mediated signal transduction//regulation of GTPase activity//defense response to bacterium//signal transduction GO:0005085 guanyl-nucleotide exchange factor activity GO:0005576 extracellular region KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.24838 BF_2 19.95 0.41 2324 642921260 XP_008192789.1 1024 2.7e-108 PREDICTED: serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X2 [Tribolium castaneum] 573910381 XM_006642846.1 228 1.88954e-113 PREDICTED: Lepisosteus oculatus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC102696354), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q5I085 969 2.7e-103 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Xenopus tropicalis GN=ppp1cb PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.24840 BF_2 232.02 15.39 918 91078504 XP_969393.1 768 5.2e-79 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X2 [Tribolium castaneum] 572317140 XM_006624116.1 117 3.69707e-52 PREDICTED: Apis dorsata uncharacterized LOC102679271 (LOC102679271), transcript variant X4, mRNA -- -- -- -- Q8IQC1 545 1.6e-54 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.24841 BF_2 13.17 0.57 1251 91087585 XP_971866.1 401 2.6e-36 PREDICTED: signal peptidase complex subunit 1 [Tribolium castaneum]>gi|270010698|gb|EFA07146.1| hypothetical protein TcasGA2_TC010137 [Tribolium castaneum] -- -- -- -- -- K12946 SPCS1 signal peptidase complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12946 Q9VAL0 285 3.0e-24 Signal peptidase complex subunit 1 OS=Drosophila melanogaster GN=Spase12 PE=1 SV=2 PF06645 Microsomal signal peptidase 12 kDa subunit (SPC12) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane KOG4112 Signal peptidase subunit Cluster-8309.24844 BF_2 140.83 5.01 1463 478254261 ENN74515.1 701 4.9e-71 hypothetical protein YQE_08839, partial [Dendroctonus ponderosae] -- -- -- -- -- K01080 PPAP2 phosphatidate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01080 Q61469 247 8.9e-20 Lipid phosphate phosphohydrolase 1 OS=Mus musculus GN=Ppap2a PE=1 SV=1 PF03600 Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family Cluster-8309.24846 BF_2 155.56 1.10 6209 642910889 XP_008193451.1 3859 0.0e+00 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] 805778458 XM_012283126.1 285 1.04941e-144 PREDICTED: Megachile rotundata SLIT-ROBO Rho GTPase-activating protein 1 (LOC100883803), transcript variant X1, mRNA K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 Q7Z6B7 1641 8.6e-181 SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens GN=SRGAP1 PE=1 SV=1 PF02321//PF16740//PF14604//PF00018//PF00620 Outer membrane efflux protein//Spindle and kinetochore-associated protein 2//Variant SH3 domain//SH3 domain//RhoGAP domain GO:0007165//GO:0006810//GO:0007067//GO:0000090//GO:0031110//GO:0051301//GO:0007059 signal transduction//transport//mitotic nuclear division//mitotic anaphase//regulation of microtubule polymerization or depolymerization//cell division//chromosome segregation GO:0005215//GO:0005515//GO:0008017 transporter activity//protein binding//microtubule binding GO:0045298//GO:0000940//GO:0005876 tubulin complex//condensed chromosome outer kinetochore//spindle microtubule -- -- Cluster-8309.24847 BF_2 92.51 2.16 2078 91089077 XP_971296.1 743 9.4e-76 PREDICTED: density-regulated protein [Tribolium castaneum]>gi|270012410|gb|EFA08858.1| hypothetical protein TcasGA2_TC006559 [Tribolium castaneum] 389609388 AK401684.1 173 6.32862e-83 Papilio xuthus mRNA for similar to CG9099, complete cds, sequence id: Px-1124 -- -- -- -- Q9VX98 667 2.5e-68 Density-regulated protein homolog OS=Drosophila melanogaster GN=DENR PE=1 SV=3 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG3239 Density-regulated protein related to translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.24850 BF_2 333.59 7.00 2280 546675694 ERL86836.1 2045 1.1e-226 hypothetical protein D910_04239 [Dendroctonus ponderosae] -- -- -- -- -- K15865 CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15865 Q291H5 1851 1.4e-205 Threonylcarbamoyladenosine tRNA methylthiotransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA19679 PE=3 SV=1 PF06444//PF04055//PF02627//PF00919 NADH dehydrogenase subunit 2 C-terminus//Radical SAM superfamily//Carboxymuconolactone decarboxylase family//Uncharacterized protein family UPF0004 GO:0006120//GO:0006814//GO:0006744//GO:0009451//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//ubiquinone biosynthetic process//RNA modification//proton transport//oxidation-reduction process GO:0003824//GO:0051920//GO:0051536//GO:0051539//GO:0008137 catalytic activity//peroxiredoxin activity//iron-sulfur cluster binding//4 iron, 4 sulfur cluster binding//NADH dehydrogenase (ubiquinone) activity -- -- KOG2492 CDK5 activator-binding protein Cluster-8309.24853 BF_2 15.00 0.45 1677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24858 BF_2 162.63 7.48 1197 642925663 XP_008194660.1 1300 1.4e-140 PREDICTED: BRCA1-associated protein [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 616 1.2e-62 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF02148//PF12678//PF17123//PF00628//PF14634//PF00097//PF13639//PF12861 Zn-finger in ubiquitin-hydrolases and other protein//RING-H2 zinc finger//RING-like zinc finger//PHD-finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.24859 BF_2 147.14 7.62 1095 270008898 EFA05346.1 849 2.5e-88 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 450 1.9e-43 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF17078//PF04513//PF02601//PF07926//PF04728//PF16740//PF13851//PF06005//PF00170//PF01297//PF04632//PF02148//PF06156//PF04111//PF07851 SWI5-dependent HO expression protein 3//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein//Lipoprotein leucine-zipper//Spindle and kinetochore-associated protein 2//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//bZIP transcription factor//Zinc-uptake complex component A periplasmic//Fusaric acid resistance protein family//Zn-finger in ubiquitin-hydrolases and other protein//Protein of unknown function (DUF972)//Autophagy protein Apg6//TMPIT-like protein GO:0006810//GO:0006914//GO:0031110//GO:0006355//GO:0007067//GO:0000090//GO:0007059//GO:0030001//GO:0043093//GO:0000917//GO:0006308//GO:0006260//GO:0051301//GO:0006606//GO:0048309//GO:0048870//GO:0051028 transport//autophagy//regulation of microtubule polymerization or depolymerization//regulation of transcription, DNA-templated//mitotic nuclear division//mitotic anaphase//chromosome segregation//metal ion transport//FtsZ-dependent cytokinesis//barrier septum assembly//DNA catabolic process//DNA replication//cell division//protein import into nucleus//endoplasmic reticulum inheritance//cell motility//mRNA transport GO:0005198//GO:0008270//GO:0043565//GO:0008855//GO:0008017//GO:0003700//GO:0046872 structural molecule activity//zinc ion binding//sequence-specific DNA binding//exodeoxyribonuclease VII activity//microtubule binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0031514//GO:0016021//GO:0005737//GO:0005876//GO:0005886//GO:0019867//GO:0019031//GO:0000940//GO:0019028//GO:0045298//GO:0009318//GO:0005667 motile cilium//integral component of membrane//cytoplasm//spindle microtubule//plasma membrane//outer membrane//viral envelope//condensed chromosome outer kinetochore//viral capsid//tubulin complex//exodeoxyribonuclease VII complex//transcription factor complex KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.24861 BF_2 1735.27 15.51 4967 642925075 XP_008194159.1 2846 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X3 [Tribolium castaneum] 642925074 XM_008195937.1 248 3.10148e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 215 1.6e-15 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF05792//PF04988//PF00096//PF13465 Candida agglutinin-like (ALS)//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007155 cell adhesion GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.24863 BF_2 10.00 0.37 1426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06971 Putative DNA-binding protein N-terminus GO:0051775//GO:0045892 response to redox state//negative regulation of transcription, DNA-templated -- -- GO:0005737 cytoplasm -- -- Cluster-8309.24866 BF_2 394.02 4.04 4372 91095259 XP_973683.1 817 5.2e-84 PREDICTED: senecionine N-oxygenase [Tribolium castaneum]>gi|270017047|gb|EFA13493.1| hypothetical protein TcasGA2_TC016303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MP06 380 1.0e-34 Senecionine N-oxygenase OS=Tyria jacobaeae GN=sno1 PE=1 SV=1 PF01494//PF00743//PF07992//PF01593//PF02789//PF05834//PF01266//PF00070 FAD binding domain//Flavin-binding monooxygenase-like//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//Cytosol aminopeptidase family, N-terminal domain//Lycopene cyclase protein//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0016117//GO:0006508 oxidation-reduction process//carotenoid biosynthetic process//proteolysis GO:0050660//GO:0004177//GO:0016491//GO:0050661//GO:0071949//GO:0004499//GO:0016705 flavin adenine dinucleotide binding//aminopeptidase activity//oxidoreductase activity//NADP binding//FAD binding//N,N-dimethylaniline monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005622 intracellular -- -- Cluster-8309.24869 BF_2 1.00 2.52 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24870 BF_2 63.00 6.46 695 817061123 XP_012252151.1 207 4.5e-14 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00448//PF00004//PF00437 SRP54-type protein, GTPase domain//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006810//GO:0006614 transport//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0005524 GTP binding//ATP binding -- -- -- -- Cluster-8309.24871 BF_2 7.00 1.99 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24872 BF_2 1.00 2.11 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24874 BF_2 15.00 0.40 1838 642925828 XP_008190476.1 269 7.7e-21 PREDICTED: uncharacterized protein LOC103312202 isoform X1 [Tribolium castaneum]>gi|270008942|gb|EFA05390.1| hypothetical protein TcasGA2_TC015562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01920//PF03462//PF07926//PF05531//PF16326 Prefoldin subunit//PCRF domain//TPR/MLP1/MLP2-like protein//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain GO:0006449//GO:0006457//GO:0006606//GO:0006415 regulation of translational termination//protein folding//protein import into nucleus//translational termination GO:0016149//GO:0003677//GO:0051082 translation release factor activity, codon specific//DNA binding//unfolded protein binding GO:0019028//GO:0018444//GO:0005737//GO:0016272//GO:0005840 viral capsid//translation release factor complex//cytoplasm//prefoldin complex//ribosome -- -- Cluster-8309.24875 BF_2 40.48 0.31 5737 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.43406e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.8e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24876 BF_2 244.96 1.97 5483 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.37017e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.7e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00439//PF00628 Bromodomain//PHD-finger -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24877 BF_2 79.61 0.65 5398 642930804 XP_008196097.1 3880 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: peregrin [Tribolium castaneum] 751215996 XM_011162629.1 112 1.34879e-48 PREDICTED: Solenopsis invicta peregrin-like (LOC105196610), partial mRNA K11348 BRPF1 bromodomain and PHD finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11348 O95696 1550 2.7e-170 Bromodomain-containing protein 1 OS=Homo sapiens GN=BRD1 PE=1 SV=1 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG0955 PHD finger protein BR140/LIN-49 Cluster-8309.24880 BF_2 318.74 19.05 987 332373724 AEE62003.1 982 8.7e-104 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q60477 456 3.5e-44 Cysteine-rich secretory protein 2 OS=Cavia porcellus GN=CRISP2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24881 BF_2 95.78 4.60 1159 478262391 ENN81062.1 221 1.8e-15 hypothetical protein YQE_02431, partial [Dendroctonus ponderosae]>gi|546673611|gb|ERL85175.1| hypothetical protein D910_02597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09830 ATP adenylyltransferase GO:0006144 purine nucleobase metabolic process GO:0003877 ATP adenylyltransferase activity -- -- -- -- Cluster-8309.24883 BF_2 87.53 1.47 2777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01342 SAND domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.24886 BF_2 2.00 0.79 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24887 BF_2 159.10 2.98 2519 642928838 XP_008195583.1 3456 0.0e+00 PREDICTED: uncharacterized protein LOC656400 [Tribolium castaneum] 642928837 XM_008197361.1 669 0 PREDICTED: Tribolium castaneum uncharacterized LOC656400 (LOC656400), mRNA -- -- -- -- Q8C8H8 337 5.6e-30 Kyphoscoliosis peptidase OS=Mus musculus GN=Ky PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.24889 BF_2 2.00 0.95 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24891 BF_2 148.58 2.01 3386 642931832 XP_008196749.1 2114 1.6e-234 PREDICTED: GPI inositol-deacylase [Tribolium castaneum]>gi|270011727|gb|EFA08175.1| hypothetical protein TcasGA2_TC005802 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q75T13 826 1.5e-86 GPI inositol-deacylase OS=Homo sapiens GN=PGAP1 PE=1 SV=1 PF07074//PF01764//PF07819 Translocon-associated protein, gamma subunit (TRAP-gamma)//Lipase (class 3)//PGAP1-like protein GO:0009987//GO:0006886//GO:0006629//GO:0006613//GO:0006505 cellular process//intracellular protein transport//lipid metabolic process//cotranslational protein targeting to membrane//GPI anchor metabolic process GO:0016788 hydrolase activity, acting on ester bonds GO:0005784//GO:0030176 Sec61 translocon complex//integral component of endoplasmic reticulum membrane KOG3724 Negative regulator of COPII vesicle formation Cluster-8309.24892 BF_2 329.06 4.79 3159 91089165 XP_973951.1 493 1.4e-46 PREDICTED: H/ACA ribonucleoprotein complex non-core subunit NAF1 [Tribolium castaneum]>gi|270011488|gb|EFA07936.1| hypothetical protein TcasGA2_TC005517 [Tribolium castaneum] -- -- -- -- -- K14763 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 http://www.genome.jp/dbget-bin/www_bget?ko:K14763 Q9VJ62 316 1.9e-27 H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Drosophila melanogaster GN=CG10341 PE=1 SV=2 PF04889//PF04410 Cwf15/Cwc15 cell cycle control protein//Gar1/Naf1 RNA binding region GO:0000398//GO:0042254//GO:0001522 mRNA splicing, via spliceosome//ribosome biogenesis//pseudouridine synthesis -- -- GO:0005681 spliceosomal complex KOG2236 Uncharacterized conserved protein Cluster-8309.24893 BF_2 421.00 15.20 1446 91090760 XP_968849.1 975 8.2e-103 PREDICTED: serine--pyruvate aminotransferase [Tribolium castaneum]>gi|270013274|gb|EFA09722.1| hypothetical protein TcasGA2_TC011855 [Tribolium castaneum] -- -- -- -- -- K00830 AGXT alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00830 P21549 710 1.8e-73 Serine--pyruvate aminotransferase OS=Homo sapiens GN=AGXT PE=1 SV=1 PF00282 Pyridoxal-dependent decarboxylase conserved domain GO:0019752 carboxylic acid metabolic process GO:0016831//GO:0030170 carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG2862 Alanine-glyoxylate aminotransferase AGT1 Cluster-8309.24896 BF_2 232.10 3.43 3117 642933797 XP_008197328.1 3837 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q8CG09 2264 2.5e-253 Multidrug resistance-associated protein 1 OS=Rattus norvegicus GN=Abcc1 PE=1 SV=2 PF00437//PF00005//PF17001//PF03193//PF00664//PF13304//PF01926 Type II/IV secretion system protein//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0009306//GO:0006810//GO:0055085 protein secretion//transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24898 BF_2 139.90 1.83 3477 478260834 ENN80486.1 1767 2.9e-194 hypothetical protein YQE_03090, partial [Dendroctonus ponderosae] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 1522 3.0e-167 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF01926//PF13304//PF00664//PF03193//PF00005 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.24899 BF_2 335.00 27.65 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2490 BF_2 18.00 0.40 2192 225382096 ACN89260.1 2005 4.6e-222 protein disulfide isomerase [Litopenaeus vannamei] 338224486 HM217893.1 387 0 Scylla paramamosain calsequestrin-1 precursor, mRNA, partial cds K09580 PDIA1, P4HB protein disulfide-isomerase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K09580 P54399 1497 1.5e-164 Protein disulfide-isomerase OS=Drosophila melanogaster GN=Pdi PE=2 SV=1 PF00462//PF00578//PF00085//PF08534//PF01216//PF07912 Glutaredoxin//AhpC/TSA family//Thioredoxin//Redoxin//Calsequestrin//ERp29, N-terminal domain GO:0006118//GO:0045454//GO:0055114//GO:0009306 obsolete electron transport//cell redox homeostasis//oxidation-reduction process//protein secretion GO:0015035//GO:0016209//GO:0005509//GO:0009055//GO:0016491 protein disulfide oxidoreductase activity//antioxidant activity//calcium ion binding//electron carrier activity//oxidoreductase activity GO:0005788 endoplasmic reticulum lumen KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.24900 BF_2 145.00 2.98 2324 270002785 EEZ99232.1 503 7.1e-48 brinker [Tribolium castaneum] 642913018 XM_001815577.2 47 7.8289e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142498 (LOC100142498), mRNA -- -- -- -- -- -- -- -- PF00253//PF04218//PF01527//PF01381//PF04145//PF02954 Ribosomal protein S14p/S29e//CENP-B N-terminal DNA-binding domain//Transposase//Helix-turn-helix//Ctr copper transporter family//Bacterial regulatory protein, Fis family GO:0042254//GO:0035434//GO:0006412//GO:0006313//GO:0006825 ribosome biogenesis//copper ion transmembrane transport//translation//transposition, DNA-mediated//copper ion transport GO:0004803//GO:0005375//GO:0003735//GO:0043565//GO:0003677 transposase activity//copper ion transmembrane transporter activity//structural constituent of ribosome//sequence-specific DNA binding//DNA binding GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane -- -- Cluster-8309.24901 BF_2 154.66 7.28 1176 642928718 XP_008199753.1 1287 4.4e-139 PREDICTED: fatty acid 2-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2LAM0 658 1.6e-67 Fatty acid 2-hydroxylase OS=Rattus norvegicus GN=Fa2h PE=1 SV=2 PF12822//PF04116 Protein of unknown function (DUF3816)//Fatty acid hydroxylase superfamily GO:0055114//GO:0006810//GO:0006633 oxidation-reduction process//transport//fatty acid biosynthetic process GO:0005215//GO:0016491//GO:0005506 transporter activity//oxidoreductase activity//iron ion binding -- -- KOG0539 Sphingolipid fatty acid hydroxylase Cluster-8309.24904 BF_2 8.00 0.51 937 123507540 XP_001329437.1 251 4.8e-19 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121912392|gb|EAY17214.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15503 ANKRD44 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K15503 Q4UMH6 225 2.0e-17 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF05396//PF13606//PF00023 Phage T7 capsid assembly protein//Ankyrin repeat//Ankyrin repeat GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- -- -- Cluster-8309.24908 BF_2 45.00 1.13 1949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01983//PF01063 Guanylyl transferase CofC like//Amino-transferase class IV GO:0008152 metabolic process GO:0016779//GO:0003824 nucleotidyltransferase activity//catalytic activity -- -- -- -- Cluster-8309.24911 BF_2 352.90 23.63 912 125629055 CAL23192.2 278 3.4e-22 gustatory receptor candidate 59 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24913 BF_2 95.60 2.64 1804 86515328 NP_001034489.1 2103 1.6e-233 homothorax [Tribolium castaneum]>gi|38490517|emb|CAD57735.1| homothorax [Tribolium castaneum]>gi|270010957|gb|EFA07405.1| hypothetical protein TcasGA2_TC008629 [Tribolium castaneum] 642930025 XM_008197995.1 420 0 PREDICTED: Tribolium castaneum homothorax (Hth), transcript variant X1, mRNA K16672 HTH homeobox protein homothorax http://www.genome.jp/dbget-bin/www_bget?ko:K16672 O46339 1303 3.9e-142 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.24915 BF_2 28.27 0.55 2456 478253032 ENN73412.1 227 7.6e-16 hypothetical protein YQE_09974, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P93748 186 1.8e-12 Putative E3 ubiquitin-protein ligase SINAT1 OS=Arabidopsis thaliana GN=SINAT1 PE=3 SV=1 PF05353//PF03145//PF02176 Delta Atracotoxin//Seven in absentia protein family//TRAF-type zinc finger GO:0009405//GO:0007275//GO:0006810//GO:0006511 pathogenesis//multicellular organismal development//transport//ubiquitin-dependent protein catabolic process GO:0008270//GO:0019871 zinc ion binding//sodium channel inhibitor activity GO:0005634//GO:0005576 nucleus//extracellular region -- -- Cluster-8309.24916 BF_2 790.00 17.46 2180 189236353 XP_001807129.1 2395 2.7e-267 PREDICTED: signal recognition particle receptor subunit alpha homolog [Tribolium castaneum]>gi|270005877|gb|EFA02325.1| hypothetical protein TcasGA2_TC007993 [Tribolium castaneum] 720030593 XM_010267260.1 42 4.41537e-10 PREDICTED: Nelumbo nucifera signal recognition particle receptor subunit alpha-like (LOC104603264), transcript variant X4, mRNA K13431 SRPR signal recognition particle receptor subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13431 Q9U5L1 1446 1.2e-158 Signal recognition particle receptor subunit alpha homolog OS=Drosophila melanogaster GN=Gtp-bp PE=1 SV=2 PF00448//PF02881//PF04086//PF01926//PF03266 SRP54-type protein, GTPase domain//SRP54-type protein, helical bundle domain//Signal recognition particle, alpha subunit, N-terminal//50S ribosome-binding GTPase//NTPase GO:0006614//GO:0006886//GO:0006184 SRP-dependent cotranslational protein targeting to membrane//intracellular protein transport//obsolete GTP catabolic process GO:0098519//GO:0003924//GO:0005047//GO:0005525 nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//signal recognition particle binding//GTP binding GO:0005786//GO:0005785 signal recognition particle, endoplasmic reticulum targeting//signal recognition particle receptor complex KOG0781 Signal recognition particle receptor, alpha subunit Cluster-8309.24918 BF_2 415.94 3.51 5249 270015427 EFA11875.1 4216 0.0e+00 hypothetical protein TcasGA2_TC004289 [Tribolium castaneum] 642939802 XM_008195501.1 487 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase 69D (LOC659057), mRNA K01104 E3.1.3.48 protein-tyrosine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01104 P16620 1984 1.2e-220 Tyrosine-protein phosphatase 69D OS=Drosophila melanogaster GN=Ptp69D PE=1 SV=2 PF00102//PF16656//PF00041//PF13895//PF01108//PF00782 Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//Tissue factor//Dual specificity phosphatase, catalytic domain GO:0006771//GO:0006570//GO:0006470//GO:0019497 riboflavin metabolic process//tyrosine metabolic process//protein dephosphorylation//hexachlorocyclohexane metabolic process GO:0046872//GO:0003993//GO:0008138//GO:0005515//GO:0004725 metal ion binding//acid phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.24919 BF_2 128.06 1.09 5180 270015427 EFA11875.1 4216 0.0e+00 hypothetical protein TcasGA2_TC004289 [Tribolium castaneum] 642939802 XM_008195501.1 487 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase 69D (LOC659057), mRNA K01104 E3.1.3.48 protein-tyrosine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01104 P16620 1984 1.2e-220 Tyrosine-protein phosphatase 69D OS=Drosophila melanogaster GN=Ptp69D PE=1 SV=2 PF00782//PF01108//PF13895//PF00041//PF16656//PF00102 Dual specificity phosphatase, catalytic domain//Tissue factor//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Protein-tyrosine phosphatase GO:0006771//GO:0006570//GO:0006470//GO:0019497 riboflavin metabolic process//tyrosine metabolic process//protein dephosphorylation//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0008138//GO:0005515//GO:0004725 acid phosphatase activity//metal ion binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.24920 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24921 BF_2 67.00 2.34 1485 546682551 ERL92474.1 957 1.0e-100 hypothetical protein D910_09787 [Dendroctonus ponderosae] -- -- -- -- -- K15442 TAD3, ADAT3 tRNA-specific adenosine deaminase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15442 Q8JFW4 445 1.0e-42 Probable inactive tRNA-specific adenosine deaminase-like protein 3 OS=Danio rerio GN=adat3 PE=2 SV=2 PF00383 Cytidine and deoxycytidylate deaminase zinc-binding region -- -- GO:0008270 zinc ion binding -- -- KOG2771 Subunit of tRNA-specific adenosine-34 deaminase Cluster-8309.24922 BF_2 9.00 0.63 888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24923 BF_2 22.00 0.49 2160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24929 BF_2 89.73 0.90 4456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24931 BF_2 8.25 1.70 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24932 BF_2 252.96 3.49 3318 642919196 XP_008191777.1 1380 2.1e-149 PREDICTED: beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase [Tribolium castaneum] -- -- -- -- -- K01001 ALG7 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01001 Q9H3H5 694 3.0e-71 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase OS=Homo sapiens GN=DPAGT1 PE=1 SV=2 PF04724//PF04410//PF00953//PF02706 Glycosyltransferase family 17//Gar1/Naf1 RNA binding region//Glycosyl transferase family 4//Chain length determinant protein GO:0009103//GO:0006487//GO:0006629//GO:0042254//GO:0001522//GO:0009252 lipopolysaccharide biosynthetic process//protein N-linked glycosylation//lipid metabolic process//ribosome biogenesis//pseudouridine synthesis//peptidoglycan biosynthetic process GO:0008963//GO:0003830 phospho-N-acetylmuramoyl-pentapeptide-transferase activity//beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2788 Glycosyltransferase Cluster-8309.24934 BF_2 17.50 0.69 1342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24935 BF_2 439.76 4.62 4270 642912951 XP_008201321.1 1057 7.5e-112 PREDICTED: uncharacterized protein LOC103315151 isoform X2 [Tribolium castaneum] -- -- -- -- -- K18407 TDRD5 tudor domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18407 Q4R3G4 152 2.7e-08 RING finger protein 17 OS=Macaca fascicularis GN=RNF17 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.24936 BF_2 58.38 0.58 4527 642916563 XP_008191711.1 329 2.1e-27 PREDICTED: uncharacterized protein LOC660226 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NEL2 162 2.0e-09 Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens GN=SOWAHB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.24937 BF_2 19.61 0.78 1341 642916731 XP_008192389.1 555 3.8e-54 PREDICTED: uncharacterized protein LOC103312734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24938 BF_2 1.00 0.70 341 557765715 XP_005182555.1 543 2.4e-53 PREDICTED: actin-5, muscle-specific [Musca domestica] 294714398 GU931401.1 137 9.82096e-64 Drosophila mauritiana actin 79B (Act79B) gene, partial cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P02574 542 1.3e-54 Actin, larval muscle OS=Drosophila melanogaster GN=Act79B PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.24940 BF_2 70.59 0.69 4567 642910521 XP_008200247.1 918 1.1e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24942 BF_2 70.83 1.17 2818 546684003 ERL93732.1 2078 2.0e-230 hypothetical protein D910_11018 [Dendroctonus ponderosae] 642929691 XM_970420.3 420 0 PREDICTED: Tribolium castaneum splicing factor 3B subunit 2 (LOC664413), transcript variant X2, mRNA K12829 SF3B2, SAP145, CUS1 splicing factor 3B subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12829 Q13435 1529 3.8e-168 Splicing factor 3B subunit 2 OS=Homo sapiens GN=SF3B2 PE=1 SV=2 PF04998//PF04037 RNA polymerase Rpb1, domain 5//Domain of unknown function (DUF382) GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus KOG2330 Splicing factor 3b, subunit 2 Cluster-8309.24944 BF_2 281.61 7.15 1934 546673062 ERL84739.1 834 2.5e-86 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 389 4.0e-36 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF01764//PF10503//PF07859//PF02230//PF11112 Lipase (class 3)//Esterase PHB depolymerase//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Pyocin activator protein PrtN GO:0006629//GO:0006355//GO:0008152 lipid metabolic process//regulation of transcription, DNA-templated//metabolic process GO:0016787 hydrolase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.24945 BF_2 8.00 1.21 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24947 BF_2 26.38 4.60 527 91085843 XP_974961.1 163 4.3e-09 PREDICTED: protein lunapark [Tribolium castaneum]>gi|270010140|gb|EFA06588.1| hypothetical protein TcasGA2_TC009502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24949 BF_2 21.68 2.21 698 531450771 AGT57862.1 376 1.1e-33 cytochrome P450 347c1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964R1 240 2.8e-19 Cytochrome P450 6j1 OS=Blattella germanica GN=CYP6J1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.2495 BF_2 23.00 1.19 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14098 Small, acid-soluble spore protein I GO:0030436 asexual sporulation -- -- -- -- -- -- Cluster-8309.24958 BF_2 27.26 0.67 1990 546672990 ERL84684.1 1209 8.3e-130 hypothetical protein D910_02111 [Dendroctonus ponderosae] 820858830 XM_003696915.2 86 1.39708e-34 PREDICTED: Apis florea pyruvate dehydrogenase E1 component subunit beta, mitochondrial (LOC100863907), mRNA K00162 PDHB, pdhB pyruvate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00162 O44451 997 1.3e-106 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Caenorhabditis elegans GN=pdhb-1 PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.24959 BF_2 140.00 1.86 3439 642917388 XP_008199670.1 586 2.5e-57 PREDICTED: slit homolog 1 protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TF66 218 4.8e-16 Leucine-rich repeat-containing protein 15 OS=Homo sapiens GN=LRRC15 PE=2 SV=2 PF07062//PF13855//PF00560 Clc-like//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.24960 BF_2 41.15 0.49 3776 91077034 XP_967567.1 1173 2.4e-125 PREDICTED: cysteine and histidine-rich domain-containing protein [Tribolium castaneum]>gi|270001750|gb|EEZ98197.1| hypothetical protein TcasGA2_TC000627 [Tribolium castaneum] -- -- -- -- -- K16729 CHORDC1, CHP1 cysteine and histidine-rich domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16729 Q9VCC0 980 2.3e-104 Cysteine and histidine-rich domain-containing protein OS=Drosophila melanogaster GN=CHORD PE=1 SV=1 PF00779//PF01082//PF03473 BTK motif//Copper type II ascorbate-dependent monooxygenase, N-terminal domain//MOSC domain GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0016715//GO:0030151//GO:0004497//GO:0030170//GO:0005507//GO:0003824 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//molybdenum ion binding//monooxygenase activity//pyridoxal phosphate binding//copper ion binding//catalytic activity -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.24964 BF_2 4.00 0.43 679 91089745 XP_975162.1 179 7.7e-11 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q57886 126 4.4e-06 RIO-type serine/threonine-protein kinase Rio1 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=rio1 PE=3 SV=1 -- -- GO:0008152//GO:0009069//GO:0016310 metabolic process//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.24965 BF_2 24.28 2.25 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24967 BF_2 9.00 5.37 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24972 BF_2 64.08 1.16 2604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24974 BF_2 815.81 10.22 3626 478255515 ENN75732.1 1353 3.0e-146 hypothetical protein YQE_07692, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P97943 477 4.7e-46 Scavenger receptor class B member 1 OS=Rattus norvegicus GN=Scarb1 PE=1 SV=1 PF00089//PF01130 Trypsin//CD36 family GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.24975 BF_2 44.80 1.14 1924 478263436 ENN81797.1 233 1.2e-16 hypothetical protein YQE_01804, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q90WD8 166 2.9e-10 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.24979 BF_2 68.90 0.46 6615 91082903 XP_972273.1 1150 1.9e-122 PREDICTED: uncharacterized protein LOC660988 isoform X1 [Tribolium castaneum]>gi|270007611|gb|EFA04059.1| hypothetical protein TcasGA2_TC014292 [Tribolium castaneum] -- -- -- -- -- K16731 GOLGA1 golgin subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16731 Q92805 295 1.1e-24 Golgin subfamily A member 1 OS=Homo sapiens GN=GOLGA1 PE=1 SV=3 PF06273//PF09497//PF04871//PF04111//PF06156//PF10018//PF08988//PF01166//PF06810//PF08066//PF01496//PF05529//PF05929//PF00038//PF02601//PF08702//PF01465//PF05837 Plant specific eukaryotic initiation factor 4B//Transcription mediator complex subunit Med12//Uso1 / p115 like vesicle tethering protein, C terminal region//Autophagy protein Apg6//Protein of unknown function (DUF972)//Vitamin-D-receptor interacting Mediator subunit 4//Type III secretion system, cytoplasmic E component of needle//TSC-22/dip/bun family//Phage minor structural protein GP20//PMC2NT (NUC016) domain//V-type ATPase 116kDa subunit family//B-cell receptor-associated protein 31-like//Phage capsid scaffolding protein (GPO) serine peptidase//Intermediate filament protein//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//GRIP domain//Centromere protein H (CENP-H) GO:0015991//GO:0019069//GO:0006308//GO:0000042//GO:0051258//GO:0006914//GO:0006886//GO:0007165//GO:0009405//GO:0015031//GO:0006355//GO:0006446//GO:0030168//GO:0051382//GO:0015992//GO:0006396//GO:0006357//GO:0006260 ATP hydrolysis coupled proton transport//viral capsid assembly//DNA catabolic process//protein targeting to Golgi//protein polymerization//autophagy//intracellular protein transport//signal transduction//pathogenesis//protein transport//regulation of transcription, DNA-templated//regulation of translational initiation//platelet activation//kinetochore assembly//proton transport//RNA processing//regulation of transcription from RNA polymerase II promoter//DNA replication GO:0008855//GO:0005515//GO:0005198//GO:0015078//GO:0008565//GO:0001104//GO:0030674//GO:0003743//GO:0003700//GO:0005102 exodeoxyribonuclease VII activity//protein binding//structural molecule activity//hydrogen ion transmembrane transporter activity//protein transporter activity//RNA polymerase II transcription cofactor activity//protein binding, bridging//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//receptor binding GO:0000176//GO:0005783//GO:0033179//GO:0016020//GO:0016021//GO:0005737//GO:0005840//GO:0005667//GO:0016592//GO:0000776//GO:0005882//GO:0005577//GO:0009318 nuclear exosome (RNase complex)//endoplasmic reticulum//proton-transporting V-type ATPase, V0 domain//membrane//integral component of membrane//cytoplasm//ribosome//transcription factor complex//mediator complex//kinetochore//intermediate filament//fibrinogen complex//exodeoxyribonuclease VII complex -- -- Cluster-8309.24981 BF_2 176.69 1.60 4915 91082903 XP_972273.1 1219 1.4e-130 PREDICTED: uncharacterized protein LOC660988 isoform X1 [Tribolium castaneum]>gi|270007611|gb|EFA04059.1| hypothetical protein TcasGA2_TC014292 [Tribolium castaneum] -- -- -- -- -- K16731 GOLGA1 golgin subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16731 Q92805 295 8.2e-25 Golgin subfamily A member 1 OS=Homo sapiens GN=GOLGA1 PE=1 SV=3 PF01166//PF05837//PF08988//PF01465//PF10018//PF08702//PF02601//PF06156//PF04111//PF05929//PF04871//PF08066//PF09497//PF06273 TSC-22/dip/bun family//Centromere protein H (CENP-H)//Type III secretion system, cytoplasmic E component of needle//GRIP domain//Vitamin-D-receptor interacting Mediator subunit 4//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Protein of unknown function (DUF972)//Autophagy protein Apg6//Phage capsid scaffolding protein (GPO) serine peptidase//Uso1 / p115 like vesicle tethering protein, C terminal region//PMC2NT (NUC016) domain//Transcription mediator complex subunit Med12//Plant specific eukaryotic initiation factor 4B GO:0015031//GO:0006355//GO:0051258//GO:0006914//GO:0006886//GO:0009405//GO:0007165//GO:0019069//GO:0006308//GO:0000042//GO:0006396//GO:0006357//GO:0006260//GO:0051382//GO:0030168//GO:0006446 protein transport//regulation of transcription, DNA-templated//protein polymerization//autophagy//intracellular protein transport//pathogenesis//signal transduction//viral capsid assembly//DNA catabolic process//protein targeting to Golgi//RNA processing//regulation of transcription from RNA polymerase II promoter//DNA replication//kinetochore assembly//platelet activation//regulation of translational initiation GO:0008565//GO:0008855//GO:0005515//GO:0003700//GO:0005102//GO:0003743//GO:0030674//GO:0001104 protein transporter activity//exodeoxyribonuclease VII activity//protein binding//transcription factor activity, sequence-specific DNA binding//receptor binding//translation initiation factor activity//protein binding, bridging//RNA polymerase II transcription cofactor activity GO:0005737//GO:0005840//GO:0016020//GO:0000176//GO:0005577//GO:0009318//GO:0000776//GO:0005667//GO:0016592 cytoplasm//ribosome//membrane//nuclear exosome (RNase complex)//fibrinogen complex//exodeoxyribonuclease VII complex//kinetochore//transcription factor complex//mediator complex -- -- Cluster-8309.24987 BF_2 9.00 0.64 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.24988 BF_2 163.60 2.79 2742 642925940 XP_008194704.1 1419 5.1e-154 PREDICTED: alpha-1D adrenergic receptor [Tribolium castaneum]>gi|270009238|gb|EFA05686.1| hypothetical protein TcasGA2_TC015120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TTM9 138 7.3e-07 Alpha-1D adrenergic receptor OS=Sus scrofa GN=ADRA1D PE=3 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.24989 BF_2 51.56 0.33 6876 546675629 ERL86779.1 7341 0.0e+00 hypothetical protein D910_04185 [Dendroctonus ponderosae] 705688754 XM_010123154.1 36 3.04538e-06 PREDICTED: Chlamydotis macqueenii activating signal cointegrator 1 complex subunit 3 (ASCC3), partial mRNA K18663 ASCC3 activating signal cointegrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18663 F1NTD6 3950 0.0e+00 Activating signal cointegrator 1 complex subunit 3 OS=Gallus gallus GN=ascc3 PE=3 SV=2 PF02562//PF00098//PF04851//PF00176//PF03051//PF00580//PF00270 PhoH-like protein//Zinc knuckle//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//Peptidase C1-like family//UvrD/REP helicase N-terminal domain//DEAD/DEAH box helicase GO:0006508 proteolysis GO:0005524//GO:0008270//GO:0016787//GO:0003677//GO:0003676//GO:0004197 ATP binding//zinc ion binding//hydrolase activity//DNA binding//nucleic acid binding//cysteine-type endopeptidase activity -- -- KOG0952 DNA/RNA helicase MER3/SLH1, DEAD-box superfamily Cluster-8309.24990 BF_2 4.11 0.70 533 817061123 XP_012252151.1 148 2.4e-07 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.24991 BF_2 78.32 0.48 7110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04494//PF00096 WD40 associated region in TFIID subunit, NTD2 domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872 metal ion binding GO:0005634 nucleus -- -- Cluster-8309.24992 BF_2 799.02 10.66 3424 546671730 ERL83919.1 584 4.3e-57 hypothetical protein D910_01211 [Dendroctonus ponderosae]>gi|546677087|gb|ERL87993.1| hypothetical protein D910_05382 [Dendroctonus ponderosae] -- -- -- -- -- K03122 TFIIA1, GTF2A1, TOA1 transcription initiation factor TFIIA large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03122 P52654 196 1.7e-13 Transcription initiation factor IIA subunit 1 OS=Drosophila melanogaster GN=TfIIA-L PE=1 SV=2 PF05365//PF03153//PF02535 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Transcription factor IIA, alpha/beta subunit//ZIP Zinc transporter GO:0006367//GO:0055085//GO:0006122//GO:0030001 transcription initiation from RNA polymerase II promoter//transmembrane transport//mitochondrial electron transport, ubiquinol to cytochrome c//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005672//GO:0005743//GO:0005750 membrane//transcription factor TFIIA complex//mitochondrial inner membrane//mitochondrial respiratory chain complex III KOG2652 RNA polymerase II transcription initiation factor TFIIA, large chain Cluster-8309.24994 BF_2 1001.92 12.82 3556 642932215 XP_008194626.1 1886 4.7e-208 PREDICTED: protein spinster isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GQQ0 1341 3.0e-146 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 PF00083//PF03137//PF07690 Sugar (and other) transporter//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.24996 BF_2 289.73 3.62 3634 642932215 XP_008194626.1 1851 5.5e-204 PREDICTED: protein spinster isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GQQ0 1391 4.9e-152 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 PF00335//PF00083//PF07690//PF03137 Tetraspanin family//Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.250 BF_2 2.00 0.32 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25001 BF_2 63.63 0.93 3148 642936917 XP_008194457.1 672 2.4e-67 PREDICTED: uncharacterized protein LOC103313294 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13516//PF12937//PF00646 Leucine Rich repeat//F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25005 BF_2 13.14 0.34 1903 91087901 XP_970608.1 819 1.3e-84 PREDICTED: protein cereblon [Tribolium castaneum]>gi|270012017|gb|EFA08465.1| hypothetical protein TcasGA2_TC006114 [Tribolium castaneum] -- -- -- -- -- K11793 CRBN cereblon http://www.genome.jp/dbget-bin/www_bget?ko:K11793 Q56AP7 279 2.3e-23 Protein cereblon OS=Rattus norvegicus GN=Crbn PE=1 SV=1 PF02190//PF02202 ATP-dependent protease La (LON) substrate-binding domain//Tachykinin family GO:0006508//GO:0006510//GO:0007268//GO:0007217 proteolysis//obsolete ATP-dependent proteolysis//synaptic transmission//tachykinin receptor signaling pathway GO:0004176 ATP-dependent peptidase activity -- -- KOG1400 Predicted ATP-dependent protease PIL, contains LON domain Cluster-8309.25008 BF_2 703.00 76.22 673 478251326 ENN71794.1 228 1.6e-16 hypothetical protein YQE_11528, partial [Dendroctonus ponderosae]>gi|546685642|gb|ERL95114.1| hypothetical protein D910_12384 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08133 Anticodon nuclease activator family GO:0050792 regulation of viral process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.25013 BF_2 76.12 3.67 1154 642926608 XP_969412.2 604 6.9e-60 PREDICTED: histone-lysine N-methyltransferase pr-set7 [Tribolium castaneum] -- -- -- -- -- K11428 SETD8 histone-lysine N-methyltransferase SETD8 http://www.genome.jp/dbget-bin/www_bget?ko:K11428 Q9VFK6 526 3.1e-52 Histone-lysine N-methyltransferase pr-set7 OS=Drosophila melanogaster GN=pr-set7 PE=1 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1085 Predicted methyltransferase (contains a SET domain) Cluster-8309.25016 BF_2 385.56 1.66 9982 91088841 XP_970807.1 2162 1.3e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.25477e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 5.7e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF01853//PF01160//PF06431//PF13508 MOZ/SAS family//Vertebrate endogenous opioids neuropeptide//Polyomavirus large T antigen C-terminus//Acetyltransferase (GNAT) domain GO:0006355//GO:0007218//GO:0006260//GO:0042967 regulation of transcription, DNA-templated//neuropeptide signaling pathway//DNA replication//acyl-carrier-protein biosynthetic process GO:0005488//GO:0016747//GO:0005524//GO:0003677//GO:0008080 binding//transferase activity, transferring acyl groups other than amino-acyl groups//ATP binding//DNA binding//N-acetyltransferase activity -- -- KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.25018 BF_2 27816.00 999.80 1451 584482886 AHJ09940.1 900 4.1e-94 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- O93883 833 9.9e-88 Polygalacturonase OS=Penicillium griseoroseum GN=PGG1 PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.25019 BF_2 15.78 0.35 2200 478260638 ENN80341.1 953 4.4e-100 hypothetical protein YQE_03333, partial [Dendroctonus ponderosae]>gi|546685233|gb|ERL94760.1| hypothetical protein D910_12034 [Dendroctonus ponderosae] -- -- -- -- -- K16723 STG M-phase inducer phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16723 P20483 438 9.5e-42 M-phase inducer phosphatase OS=Drosophila melanogaster GN=stg PE=1 SV=2 PF00598 Influenza Matrix protein (M1) -- -- GO:0003723//GO:0005198 RNA binding//structural molecule activity -- -- KOG3772 M-phase inducer phosphatase Cluster-8309.25020 BF_2 303.20 3.53 3882 642931678 XP_008196684.1 193 1.1e-11 PREDICTED: neurofilament heavy polypeptide-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25022 BF_2 891.00 8.06 4911 642917526 XP_008191240.1 3541 0.0e+00 PREDICTED: WD repeat-containing protein 44 [Tribolium castaneum]>gi|642917528|ref|XP_008191241.1| PREDICTED: WD repeat-containing protein 44 [Tribolium castaneum]>gi|270003437|gb|EEZ99884.1| hypothetical protein TcasGA2_TC002668 [Tribolium castaneum] 815811139 XM_012371063.1 236 1.43672e-117 PREDICTED: Linepithema humile WD repeat-containing protein 44 (LOC105674607), mRNA -- -- -- -- Q6NVE8 1709 8.9e-189 WD repeat-containing protein 44 OS=Mus musculus GN=Wdr44 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0283 WD40 repeat-containing protein Cluster-8309.25026 BF_2 580.34 13.87 2037 91084815 XP_973232.1 1336 1.6e-144 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|642925910|ref|XP_008194692.1| PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008959|gb|EFA05407.1| hypothetical protein TcasGA2_TC015583 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 314 2.1e-27 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.25028 BF_2 1732.80 38.25 2182 91088333 XP_970609.1 1524 2.7e-166 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12302 SLC17A6_7_8 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12302 Q9V7S5 854 5.5e-90 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF06444//PF07690//PF00083 NADH dehydrogenase subunit 2 C-terminus//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006120//GO:0006814//GO:0006744//GO:0015992//GO:0055114 transmembrane transport//mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//ubiquinone biosynthetic process//proton transport//oxidation-reduction process GO:0022857//GO:0008137 transmembrane transporter activity//NADH dehydrogenase (ubiquinone) activity GO:0016021 integral component of membrane -- -- Cluster-8309.25031 BF_2 3.31 0.35 688 270012263 EFA08711.1 248 7.8e-19 hypothetical protein TcasGA2_TC006382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2A2 138 1.8e-07 tRNA-splicing endonuclease subunit Sen54 OS=Mus musculus GN=Tsen54 PE=2 SV=2 PF02778 tRNA intron endonuclease, N-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213 tRNA-intron endonuclease activity GO:0000214 tRNA-intron endonuclease complex -- -- Cluster-8309.25033 BF_2 34.47 3.92 655 565318244 ETE69548.1 148 2.9e-07 Histone-lysine N-methyltransferase, H3 lysine-79 specific, partial [Ophiophagus hannah] -- -- -- -- -- -- -- -- -- Q8H0U8 138 1.7e-07 DEAD-box ATP-dependent RNA helicase 42 OS=Arabidopsis thaliana GN=RH42 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25034 BF_2 65.51 2.38 1439 642927776 XP_008195401.1 190 8.7e-12 PREDICTED: receptor-type tyrosine-protein phosphatase F-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25037 BF_2 346.26 8.46 1999 91089769 XP_967094.1 1002 8.4e-106 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013610|gb|EFA10058.1| hypothetical protein TcasGA2_TC012232 [Tribolium castaneum] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 B4MYA4 520 2.7e-51 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.25039 BF_2 25.12 0.31 3701 642936562 XP_008198486.1 1449 2.3e-157 PREDICTED: somatostatin receptor type 2 isoform X1 [Tribolium castaneum] 462360042 APGK01029530.1 119 1.18417e-52 Dendroctonus ponderosae Seq01029540, whole genome shotgun sequence K04218 SSTR2 somatostatin receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04218 P30874 580 5.5e-58 Somatostatin receptor type 2 OS=Homo sapiens GN=SSTR2 PE=1 SV=1 PF13994//PF00001 PgaD-like protein//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0042710 G-protein coupled receptor signaling pathway//biofilm formation GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.25040 BF_2 203.50 5.61 1805 642928556 XP_008195374.1 1034 1.5e-109 PREDICTED: serine protease easter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 570 3.9e-57 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25042 BF_2 300.53 2.31 5732 642922377 XP_008193132.1 2202 1.7e-244 PREDICTED: insulin-like growth factor 2 mRNA-binding protein 1 isoform X4 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.64343e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 O88477 955 2.8e-101 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Mus musculus GN=Igf2bp1 PE=1 SV=1 PF00013//PF13184//PF13014//PF00076//PF04061//PF07650 KH domain//NusA-like KH domain//KH domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ORMDL family//KH domain -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.25045 BF_2 494.23 7.95 2888 642921567 XP_008192427.1 3430 0.0e+00 PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921569|ref|XP_008192428.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|642921571|ref|XP_008192429.1| PREDICTED: vam6/Vps39-like protein [Tribolium castaneum]>gi|270005017|gb|EFA01465.1| hypothetical protein TcasGA2_TC007012 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5L3 1665 6.6e-184 Vam6/Vps39-like protein OS=Mus musculus GN=Vps39 PE=2 SV=1 PF13181//PF02891//PF13374//PF00515//PF06464//PF13176//PF00637 Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//Tetratricopeptide repeat//DMAP1-binding Domain//Tetratricopeptide repeat//Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0005515//GO:0008134 zinc ion binding//protein binding//transcription factor binding GO:0005622//GO:0005667//GO:0005634 intracellular//transcription factor complex//nucleus KOG2063 Vacuolar assembly/sorting proteins VPS39/VAM6/VPS3 Cluster-8309.25046 BF_2 54.68 1.67 1653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25047 BF_2 3.00 0.93 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25051 BF_2 80.51 4.58 1022 478256925 ENN77094.1 666 3.9e-67 hypothetical protein YQE_06429, partial [Dendroctonus ponderosae]>gi|546683033|gb|ERL92899.1| hypothetical protein D910_10204 [Dendroctonus ponderosae] -- -- -- -- -- K06963 TAN1, THUMPD1 tRNA acetyltransferase TAN1 http://www.genome.jp/dbget-bin/www_bget?ko:K06963 Q9VZD8 442 1.5e-42 THUMP domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG15014 PE=1 SV=2 PF03526//PF02926 Colicin E1 (microcin) immunity protein//THUMP domain GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0003723//GO:0015643 RNA binding//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.25053 BF_2 69.95 0.62 5039 91081535 XP_974904.1 2249 5.4e-250 PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921048|ref|XP_008192670.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|642921050|ref|XP_008192671.1| PREDICTED: histone-lysine N-methyltransferase Suv4-20 [Tribolium castaneum]>gi|270006169|gb|EFA02617.1| hypothetical protein TcasGA2_TC008337 [Tribolium castaneum] 642921051 XM_969811.2 41 3.7028e-09 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase Suv4-20 (LOC663776), transcript variant X3, mRNA K11429 SUV420H histone-lysine N-methyltransferase SUV420H http://www.genome.jp/dbget-bin/www_bget?ko:K11429 Q9W5E0 1092 3.2e-117 Histone-lysine N-methyltransferase Suv4-20 OS=Drosophila melanogaster GN=Hmt4-20 PE=1 SV=1 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2589 Histone tail methylase Cluster-8309.25057 BF_2 15.46 0.66 1263 189233697 XP_966459.2 603 9.8e-60 PREDICTED: uncharacterized protein C17orf59 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66H43 128 4.9e-06 Uncharacterized protein C17orf59 homolog OS=Rattus norvegicus PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25058 BF_2 8.62 0.31 1466 642919467 XP_008191881.1 808 1.9e-83 PREDICTED: polyprenol reductase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 526 4.0e-52 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0005737//GO:0016021 cytoplasm//integral component of membrane KOG1640 Predicted steroid reductase Cluster-8309.25066 BF_2 479.96 17.06 1464 91080041 XP_972705.1 1298 2.9e-140 PREDICTED: tumor susceptibility gene 101 protein [Tribolium castaneum]>gi|270003221|gb|EEZ99668.1| hypothetical protein TcasGA2_TC002425 [Tribolium castaneum] -- -- -- -- -- K12183 TSG101, STP22, VPS23 ESCRT-I complex subunit TSG101 http://www.genome.jp/dbget-bin/www_bget?ko:K12183 Q61187 450 2.6e-43 Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2 PF02601//PF09177//PF03938//PF01496//PF05743//PF01763//PF04977//PF04111 Exonuclease VII, large subunit//Syntaxin 6, N-terminal//Outer membrane protein (OmpH-like)//V-type ATPase 116kDa subunit family//UEV domain//Herpesvirus UL6 like//Septum formation initiator//Autophagy protein Apg6 GO:0006464//GO:0015991//GO:0048193//GO:0006914//GO:0015031//GO:0006323//GO:0007049//GO:0015992//GO:0006308 cellular protein modification process//ATP hydrolysis coupled proton transport//Golgi vesicle transport//autophagy//protein transport//DNA packaging//cell cycle//proton transport//DNA catabolic process GO:0008855//GO:0015078//GO:0051082 exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//unfolded protein binding GO:0016020//GO:0009318//GO:0033179 membrane//exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain KOG2391 Vacuolar sorting protein/ubiquitin receptor VPS23 Cluster-8309.25071 BF_2 148.18 1.86 3625 642921203 XP_008192760.1 1312 1.7e-141 PREDICTED: uncharacterized protein LOC103312841 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 P82798 286 6.6e-24 Transcriptional regulator ATRX (Fragment) OS=Macropus eugenii GN=ATRX PE=2 SV=1 PF00539//PF00628//PF01152 Transactivating regulatory protein (Tat)//PHD-finger//Bacterial-like globin GO:0006355 regulation of transcription, DNA-templated GO:0019825//GO:0005515//GO:0003700 oxygen binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.25072 BF_2 148.00 4.12 1790 91091998 XP_969961.1 992 1.1e-104 PREDICTED: syntaxin-18 [Tribolium castaneum]>gi|642937771|ref|XP_008198938.1| PREDICTED: syntaxin-18 [Tribolium castaneum]>gi|270001158|gb|EEZ97605.1| hypothetical protein TcasGA2_TC011475 [Tribolium castaneum] -- -- -- -- -- K08492 STX18 syntaxin 18 http://www.genome.jp/dbget-bin/www_bget?ko:K08492 Q8VDS8 557 1.2e-55 Syntaxin-18 OS=Mus musculus GN=Stx18 PE=2 SV=2 PF05739//PF07851//PF07998//PF00170 SNARE domain//TMPIT-like protein//Peptidase family M54//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0005515//GO:0003700 zinc ion binding//sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG3894 SNARE protein Syntaxin 18/UFE1 Cluster-8309.25074 BF_2 100.00 5.07 1112 189241033 XP_971712.2 357 2.9e-31 PREDICTED: probable peptide chain release factor C12orf65, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5WUX7 273 6.6e-23 Probable peptide chain release factor C12orf65 homolog, mitochondrial OS=Danio rerio GN=si:ch211-275j6.5 PE=3 SV=1 PF00472 RF-1 domain GO:0006449//GO:0006415 regulation of translational termination//translational termination GO:0003747 translation release factor activity GO:0005840//GO:0018444 ribosome//translation release factor complex KOG2726 Mitochondrial polypeptide chain release factor Cluster-8309.25076 BF_2 24.58 0.43 2653 642912009 XP_008199058.1 513 5.6e-49 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X1 [Tribolium castaneum]>gi|270014484|gb|EFA10932.1| hypothetical protein TcasGA2_TC001759 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PE2 329 5.0e-29 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 -- -- GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005622 intracellular KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.25077 BF_2 16.72 0.63 1404 270008898 EFA05346.1 296 4.3e-24 hypothetical protein TcasGA2_TC015510 [Tribolium castaneum] -- -- -- -- -- K10632 BRAP BRCA1-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K10632 Q7Z569 170 7.3e-11 BRCA1-associated protein OS=Homo sapiens GN=BRAP PE=1 SV=2 PF02148 Zn-finger in ubiquitin-hydrolases and other protein -- -- GO:0008270 zinc ion binding -- -- KOG0804 Cytoplasmic Zn-finger protein BRAP2 (BRCA1 associated protein) Cluster-8309.25078 BF_2 40.18 2.18 1058 642925667 XP_008194662.1 631 4.7e-63 PREDICTED: uncharacterized protein LOC663019 isoform X2 [Tribolium castaneum]>gi|270008899|gb|EFA05347.1| hypothetical protein TcasGA2_TC015511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25080 BF_2 20.41 0.64 1624 546684909 ERL94491.1 1492 1.0e-162 hypothetical protein D910_11768 [Dendroctonus ponderosae] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 822 2.1e-86 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.25081 BF_2 481.46 5.16 4187 642934418 XP_008197653.1 541 5.0e-52 PREDICTED: transformer-2 protein homolog beta isoform X4 [Tribolium castaneum] 642934413 XM_008199429.1 299 1.16424e-152 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X2, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 3.7e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF00076//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.25082 BF_2 560.28 8.53 3035 642920248 XP_008192267.1 1434 1.0e-155 PREDICTED: probable cytochrome P450 6a14 [Tribolium castaneum]>gi|270006371|gb|EFA02819.1| cytochrome P450 6BQ5 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 994 4.4e-106 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF03776//PF00893//PF00067 Septum formation topological specificity factor MinE//Small Multidrug Resistance protein//Cytochrome P450 GO:0055114//GO:0032955//GO:0051301 oxidation-reduction process//regulation of barrier septum assembly//cell division GO:0020037//GO:0005506//GO:0005488//GO:0016491//GO:0016705 heme binding//iron ion binding//binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016021 integral component of membrane -- -- Cluster-8309.25086 BF_2 359.88 4.72 3479 642931826 XP_971415.2 1148 1.7e-122 PREDICTED: runt-related transcription factor 3 [Tribolium castaneum] 768414739 XM_011549587.1 112 8.66073e-49 PREDICTED: Plutella xylostella runt-related transcription factor 3 (LOC105380090), mRNA K08367 RUNX1, AML1 runt-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08367 Q9W349 529 4.2e-52 Protein lozenge OS=Drosophila melanogaster GN=lz PE=2 SV=2 PF15800//PF00853 Clock interacting protein circadian//Runt domain GO:0045892//GO:0006355//GO:0042754 negative regulation of transcription, DNA-templated//regulation of transcription, DNA-templated//negative regulation of circadian rhythm GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3982 Runt and related transcription factors Cluster-8309.25091 BF_2 40.89 0.51 3609 478250074 ENN70580.1 978 9.2e-103 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 98 5.44763e-41 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.5e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF08030//PF00175 Ferric reductase NAD binding domain//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.25092 BF_2 114.00 3.69 1579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04053 Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198 structural molecule activity GO:0030117 membrane coat -- -- Cluster-8309.25093 BF_2 547.97 6.81 3655 642924025 XP_008193975.1 1924 1.9e-212 PREDICTED: WD repeat-containing protein 37 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DDF0 1066 2.4e-114 WD repeat-containing protein 37 OS=Xenopus laevis GN=wdr37 PE=2 SV=1 PF15898//PF02183//PF00400 cGMP-dependent protein kinase interacting domain//Homeobox associated leucine zipper//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0019901//GO:0043565//GO:0005515//GO:0003700 protein kinase binding//sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG0300 WD40 repeat-containing protein Cluster-8309.25094 BF_2 270.03 3.37 3639 642924025 XP_008193975.1 1823 9.7e-201 PREDICTED: WD repeat-containing protein 37 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R650 1015 2.0e-108 WD repeat-containing protein 37 OS=Pongo abelii GN=WDR37 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0300 WD40 repeat-containing protein Cluster-8309.25095 BF_2 18.00 1.76 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25096 BF_2 137.97 1.53 4069 642936958 XP_008198629.1 569 2.8e-55 PREDICTED: bromodomain-containing protein 4-like [Tribolium castaneum]>gi|270001028|gb|EEZ97475.1| hypothetical protein TcasGA2_TC011309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25097 BF_2 298.00 5.55 2532 91084817 XP_973265.1 2979 0.0e+00 PREDICTED: ribosome biogenesis protein BOP1 homolog [Tribolium castaneum]>gi|270008960|gb|EFA05408.1| hypothetical protein TcasGA2_TC015584 [Tribolium castaneum] 571500889 XM_006561925.1 119 8.07038e-53 PREDICTED: Apis mellifera ribosome biogenesis protein BOP1 homolog (LOC551531), mRNA K14824 ERB1, BOP1 ribosome biogenesis protein ERB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14824 Q17LZ2 2486 3.6e-279 Ribosome biogenesis protein BOP1 homolog OS=Aedes aegypti GN=AAEL001169 PE=3 SV=1 PF01643//PF15957//PF00400//PF00335//PF08145 Acyl-ACP thioesterase//Commissureless//WD domain, G-beta repeat//Tetraspanin family//BOP1NT (NUC169) domain GO:0006364//GO:0006633//GO:0007411//GO:0051726 rRNA processing//fatty acid biosynthetic process//axon guidance//regulation of cell cycle GO:0016790//GO:0005515 thiolester hydrolase activity//protein binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0650 WD40 repeat nucleolar protein Bop1, involved in ribosome biogenesis Cluster-8309.25098 BF_2 982.85 9.62 4561 728418761 AIY68380.1 1519 2.2e-165 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 709 7.5e-73 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF12763//PF08115//PF13499//PF01153//PF13833//PF13405//PF00326//PF07859//PF13202//PF00036//PF03874 Cytoskeletal-regulatory complex EF hand//SFI toxin family//EF-hand domain pair//Glypican//EF-hand domain pair//EF-hand domain//Prolyl oligopeptidase family//alpha/beta hydrolase fold//EF hand//EF hand//RNA polymerase Rpb4 GO:0006351//GO:0008152//GO:0006144//GO:0006508//GO:0006206//GO:0009405 transcription, DNA-templated//metabolic process//purine nucleobase metabolic process//proteolysis//pyrimidine nucleobase metabolic process//pathogenesis GO:0005515//GO:0005509//GO:0043395//GO:0016787//GO:0003899//GO:0008236 protein binding//calcium ion binding//heparan sulfate proteoglycan binding//hydrolase activity//DNA-directed RNA polymerase activity//serine-type peptidase activity GO:0016020//GO:0005576//GO:0005578//GO:0005730 membrane//extracellular region//proteinaceous extracellular matrix//nucleolus -- -- Cluster-8309.25099 BF_2 525.67 4.44 5239 728418761 AIY68380.1 1520 1.9e-165 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 711 5.0e-73 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF07859//PF13202//PF00326//PF03874//PF00036//PF08463//PF08115//PF12763//PF13405//PF13833//PF13499//PF01153 alpha/beta hydrolase fold//EF hand//Prolyl oligopeptidase family//RNA polymerase Rpb4//EF hand//EcoEI R protein C-terminal//SFI toxin family//Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF-hand domain pair//EF-hand domain pair//Glypican GO:0006206//GO:0006508//GO:0006351//GO:0008152//GO:0006144//GO:0006304//GO:0009405 pyrimidine nucleobase metabolic process//proteolysis//transcription, DNA-templated//metabolic process//purine nucleobase metabolic process//DNA modification//pathogenesis GO:0005509//GO:0003677//GO:0003824//GO:0005515//GO:0008236//GO:0043395//GO:0016787//GO:0003899 calcium ion binding//DNA binding//catalytic activity//protein binding//serine-type peptidase activity//heparan sulfate proteoglycan binding//hydrolase activity//DNA-directed RNA polymerase activity GO:0016020//GO:0005576//GO:0005578//GO:0005730 membrane//extracellular region//proteinaceous extracellular matrix//nucleolus -- -- Cluster-8309.251 BF_2 18.00 0.57 1605 642933863 XP_008197542.1 1136 2.0e-121 PREDICTED: 5-hydroxytryptamine receptor-like [Tribolium castaneum] 768430080 XM_011557948.1 176 1.04532e-84 PREDICTED: Plutella xylostella 5-hydroxytryptamine receptor-like (LOC105387247), partial mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q17239 906 3.8e-96 5-hydroxytryptamine receptor OS=Bombyx mori PE=2 SV=1 PF00001//PF03821 7 transmembrane receptor (rhodopsin family)//Golgi 4-transmembrane spanning transporter GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.25100 BF_2 100.00 4.27 1267 -- -- -- -- -- 462346509 APGK01034266.1 92 4.06727e-38 Dendroctonus ponderosae Seq01034276, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25102 BF_2 5.18 1.45 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25103 BF_2 110.50 1.86 2776 642923711 XP_974199.2 2950 0.0e+00 PREDICTED: protein smg8 [Tribolium castaneum] -- -- -- -- -- K18734 SMG8 protein SMG8 http://www.genome.jp/dbget-bin/www_bget?ko:K18734 B0W730 645 1.2e-65 Protein SMG8 OS=Culex quinquefasciatus GN=CPIJ003128 PE=3 SV=1 PF10220//PF08653 Uncharacterized conserved protein (DUF2146)//DASH complex subunit Dam1 GO:0000184//GO:0008608 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG3692 Uncharacterized conserved protein Cluster-8309.25105 BF_2 83.24 1.15 3314 91081621 XP_966892.1 1552 2.3e-169 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O24145 893 2.5e-94 4-coumarate--CoA ligase 1 OS=Nicotiana tabacum GN=4CL1 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.25106 BF_2 1.00 11.84 229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25107 BF_2 331.45 2.38 6124 91076220 XP_972698.1 2878 0.0e+00 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 212 3.93912e-104 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q9H2Y9 912 2.9e-96 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF03137//PF07690//PF00050//PF07648 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0006810//GO:0055085 transport//transmembrane transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.25112 BF_2 238.00 6.68 1777 332372967 AEE61625.1 1127 2.4e-120 unknown [Dendroctonus ponderosae]>gi|546687201|gb|ERL96033.1| hypothetical protein D910_00850 [Dendroctonus ponderosae] 332372966 BT126662.1 195 3.17948e-95 Dendroctonus ponderosae clone DPO112_K06 unknown mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 512 2.0e-50 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.25113 BF_2 155.51 4.89 1617 91076712 XP_972315.1 865 5.2e-90 PREDICTED: protein MAK16 homolog [Tribolium castaneum]>gi|270001893|gb|EEZ98340.1| hypothetical protein TcasGA2_TC000795 [Tribolium castaneum] 676494334 XM_009068281.1 96 3.12113e-40 Lottia gigantea hypothetical protein mRNA K14831 MAK16 protein MAK16 http://www.genome.jp/dbget-bin/www_bget?ko:K14831 Q66L33 628 6.5e-64 Protein MAK16 homolog A OS=Xenopus laevis GN=mak16-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3064 RNA-binding nuclear protein (MAK16) containing a distinct C4 Zn-finger Cluster-8309.25114 BF_2 11.00 1.96 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25115 BF_2 65.00 5.34 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.25117 BF_2 380.41 7.42 2432 642922652 XP_008193262.1 1670 3.6e-183 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 757 1.1e-78 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF02172//PF09606 KIX domain//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005667 mediator complex//transcription factor complex -- -- Cluster-8309.25118 BF_2 39.88 0.40 4426 642922652 XP_008193262.1 1318 4.2e-142 PREDICTED: mediator of RNA polymerase II transcription subunit 15-like [Tribolium castaneum]>gi|270007150|gb|EFA03598.1| hypothetical protein TcasGA2_TC013685 [Tribolium castaneum] -- -- -- -- -- K15157 MED15 mediator of RNA polymerase II transcription subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K15157 Q17BA4 758 1.5e-78 Mediator of RNA polymerase II transcription subunit 15 OS=Aedes aegypti GN=MED15 PE=3 SV=1 PF09606//PF02172//PF16987 ARC105 or Med15 subunit of Mediator complex non-fungal//KIX domain//KIX domain GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003712//GO:0001104 transcription cofactor activity//RNA polymerase II transcription cofactor activity GO:0005667//GO:0016592 transcription factor complex//mediator complex -- -- Cluster-8309.25119 BF_2 789.03 6.19 5617 189241815 XP_971376.2 4256 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1079 1.1e-115 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF13180//PF00397//PF00595 PDZ domain//WW domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.25120 BF_2 3.00 8.65 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25121 BF_2 16.96 13.80 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25122 BF_2 267.39 5.57 2294 270014969 EFA11417.1 762 6.5e-78 hypothetical protein TcasGA2_TC013593 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25123 BF_2 22.28 0.46 2294 270014969 EFA11417.1 762 6.5e-78 hypothetical protein TcasGA2_TC013593 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25127 BF_2 25.00 1.74 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25133 BF_2 3.12 1.29 387 606236564 AHW40461.1 605 1.8e-60 actin, partial [Zygaena filipendulae] 530723032 KC131028.1 252 1.33186e-127 Portunus trituberculatus skeletal muscle actin 2 mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P10987 596 8.0e-61 Actin-5C OS=Drosophila melanogaster GN=Act5C PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25134 BF_2 1.00 0.65 346 768189842 KJH46221.1 451 1.1e-42 Actin [Dictyocaulus viviparus] 338224304 HM217789.1 236 9.23317e-119 Scylla paramamosain isolate 1 cytoplasmic type actin-like mRNA, partial sequence K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P12431 442 5.2e-43 Actin, muscle OS=Strongylocentrotus purpuratus PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25135 BF_2 722.88 8.19 3979 189237657 XP_001812177.1 794 2.2e-81 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 352 1.6e-31 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428//PF01536 AN1-like Zinc finger//Adenosylmethionine decarboxylase GO:0006525//GO:0006560//GO:0008295//GO:0006597 arginine metabolic process//proline metabolic process//spermidine biosynthetic process//spermine biosynthetic process GO:0008270//GO:0004014 zinc ion binding//adenosylmethionine decarboxylase activity -- -- KOG3183 Predicted Zn-finger protein Cluster-8309.25136 BF_2 81.82 2.59 1611 189237657 XP_001812177.1 383 4.1e-34 PREDICTED: AN1-type zinc finger protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TCF1 204 9.5e-15 AN1-type zinc finger protein 1 OS=Homo sapiens GN=ZFAND1 PE=1 SV=1 PF01428 AN1-like Zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.25138 BF_2 123.97 1.09 5025 642914078 XP_969963.3 2060 4.4e-228 PREDICTED: uncharacterized protein LOC658486 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05529//PF15898//PF17078//PF15177 B-cell receptor-associated protein 31-like//cGMP-dependent protein kinase interacting domain//SWI5-dependent HO expression protein 3//Interleukin-28A GO:0007165//GO:0007259//GO:0051028//GO:0051607//GO:0050778//GO:0006886//GO:0048309 signal transduction//JAK-STAT cascade//mRNA transport//defense response to virus//positive regulation of immune response//intracellular protein transport//endoplasmic reticulum inheritance GO:0019901//GO:0005125 protein kinase binding//cytokine activity GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.25140 BF_2 52.23 4.70 752 91086459 XP_969641.1 393 1.3e-35 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 O62515 236 8.6e-19 Probable phytanoyl-CoA dioxygenase OS=Caenorhabditis elegans GN=ZK550.6 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25145 BF_2 19.00 0.47 1977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25146 BF_2 458.92 8.53 2538 229892267 NP_001153545.1 2079 1.4e-230 uncharacterized MFS-type transporter [Tribolium castaneum]>gi|270007334|gb|EFA03782.1| hypothetical protein TcasGA2_TC013893 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NT16 648 4.9e-66 MFS-type transporter SLC18B1 OS=Homo sapiens GN=SLC18B1 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.25147 BF_2 38.67 0.70 2608 189235703 XP_001807591.1 2643 5.7e-296 PREDICTED: CAS1 domain-containing protein 1 [Tribolium castaneum] 642917634 XM_001807539.2 82 3.07682e-32 PREDICTED: Tribolium castaneum CAS1 domain-containing protein 1 (LOC655926), mRNA -- -- -- -- Q7TN73 1227 3.7e-133 CAS1 domain-containing protein 1 OS=Mus musculus GN=Casd1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1699 O-acetyltransferase Cluster-8309.25148 BF_2 13.61 0.31 2133 189233648 XP_972556.2 1826 2.5e-201 PREDICTED: beta-arrestin-1 isoform X4 [Tribolium castaneum] 642910565 XM_967463.3 515 0 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 Q4R562 1154 8.7e-125 Beta-arrestin-1 OS=Macaca fascicularis GN=ARRB1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.25149 BF_2 5.00 9.12 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25154 BF_2 32.31 0.45 3302 646702398 KDR11610.1 703 6.5e-71 GTP-binding protein Rheb-like protein [Zootermopsis nevadensis] 556946329 XM_005986343.1 39 3.12687e-08 PREDICTED: Latimeria chalumnae GTP-binding protein Rheb-like (LOC102353752), mRNA K07208 RHEB Ras homolog enriched in brain http://www.genome.jp/dbget-bin/www_bget?ko:K07208 Q9VND8 622 6.6e-63 GTP-binding protein Rheb homolog OS=Drosophila melanogaster GN=Rheb PE=2 SV=1 PF03193//PF08477//PF01637//PF01926//PF00025//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//Archaeal ATPase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.25156 BF_2 126.40 1.56 3686 91091602 XP_975764.1 2842 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X7 [Tribolium castaneum] 642937044 XM_970671.2 557 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X7, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 1982 1.5e-220 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400//PF09266//PF11540 WD domain, G-beta repeat//Viral DNA topoisomerase I, N-terminal//Cytoplasmic dynein 1 intermediate chain 2 GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0003916//GO:0005515//GO:0003677 DNA topoisomerase activity//protein binding//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.25157 BF_2 80.49 1.20 3093 642937041 XP_008198664.1 1343 3.7e-145 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X5 [Tribolium castaneum] 501300159 AK418404.1 77 2.19941e-29 Riptortus pedestris mRNA for cytoplasmic dynein intermediate chain, partial cds, sequence id: Rped-0877, expressed in midgut K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 O88487 947 1.3e-100 Cytoplasmic dynein 1 intermediate chain 2 OS=Mus musculus GN=Dync1i2 PE=1 SV=1 PF00400//PF02742 WD domain, G-beta repeat//Iron dependent repressor, metal binding and dimerisation domain -- -- GO:0046914//GO:0046983//GO:0005515 transition metal ion binding//protein dimerization activity//protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.25160 BF_2 297.59 3.71 3646 642938137 XP_008199781.1 1838 1.8e-202 PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|642938140|ref|XP_008199782.1| PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|270016485|gb|EFA12931.1| hypothetical protein TcasGA2_TC010477 [Tribolium castaneum] 194750862 XM_001957713.1 248 2.2706e-124 Drosophila ananassae GF10569 (Dana\GF10569), mRNA K08827 PRPF4B serine/threonine-protein kinase PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K08827 Q13523 1338 6.9e-146 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens GN=PRPF4B PE=1 SV=3 PF05445//PF07714//PF00069 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0670 U4/U6-associated splicing factor PRP4 Cluster-8309.25161 BF_2 179.91 2.40 3425 642938137 XP_008199781.1 1838 1.7e-202 PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|642938140|ref|XP_008199782.1| PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|270016485|gb|EFA12931.1| hypothetical protein TcasGA2_TC010477 [Tribolium castaneum] 194750862 XM_001957713.1 248 2.1316e-124 Drosophila ananassae GF10569 (Dana\GF10569), mRNA K08827 PRPF4B serine/threonine-protein kinase PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K08827 Q13523 1338 6.5e-146 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens GN=PRPF4B PE=1 SV=3 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0670 U4/U6-associated splicing factor PRP4 Cluster-8309.25162 BF_2 40.18 0.97 2023 642924858 XP_008194069.1 1120 1.8e-119 PREDICTED: uncharacterized protein LOC103313199 [Tribolium castaneum]>gi|270006682|gb|EFA03130.1| hypothetical protein TcasGA2_TC013041 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04333//PF00168 MlaA lipoprotein//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.25168 BF_2 5.00 0.44 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06221 Putative zinc finger motif, C2HC5-type GO:0006355 regulation of transcription, DNA-templated GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25169 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25170 BF_2 280.27 1.87 6541 835482914 AKM70276.1 219 1.7e-14 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25171 BF_2 151.97 1.01 6556 835482914 AKM70276.1 219 1.7e-14 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25172 BF_2 405.62 5.36 3452 642924116 XP_008194013.1 1767 2.9e-194 PREDICTED: growth factor receptor-bound protein 14-like isoform X3 [Tribolium castaneum] 642924115 XM_008195791.1 53 5.39579e-16 PREDICTED: Tribolium castaneum growth factor receptor-bound protein 14-like (LOC657107), transcript variant X3, mRNA -- -- -- -- Q5ICW4 730 2.1e-75 Growth factor receptor-bound protein 14 OS=Bos taurus GN=GRB14 PE=1 SV=1 PF05356//PF00788 Phage Coat protein B//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0019028 viral capsid KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.25173 BF_2 396.00 3.02 5773 91076464 XP_971999.1 5711 0.0e+00 PREDICTED: slit homolog 2 protein [Tribolium castaneum]>gi|270002905|gb|EEZ99352.1| toll-6 [Tribolium castaneum] 817193060 XM_012416560.1 120 5.15379e-53 PREDICTED: Orussus abietinus protein toll-like (LOC105695206), mRNA -- -- -- -- O75094 422 1.8e-39 Slit homolog 3 protein OS=Homo sapiens GN=SLIT3 PE=2 SV=3 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165//GO:0045087 signal transduction//innate immune response GO:0004888//GO:0005515 transmembrane signaling receptor activity//protein binding GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.25175 BF_2 119.02 1.47 3674 642917307 XP_008199245.1 5410 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X6 [Tribolium castaneum] 665815961 XM_008558446.1 642 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3654 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF00501//PF06464//PF17096 AMP-binding enzyme//DMAP1-binding Domain//Altered inheritance of mitochondria protein 3 GO:0008152//GO:0051016 metabolic process//barbed-end actin filament capping GO:0003824//GO:0008134 catalytic activity//transcription factor binding GO:0005634//GO:0030479//GO:0005667 nucleus//actin cortical patch//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.25179 BF_2 1538.61 5.46 12078 642931485 XP_008196605.1 917 3.7e-95 PREDICTED: insulin receptor substrate 1 isoform X9 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 1.5e-48 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF02174//PF12814 PTB domain (IRS-1 type)//Meiotic cell cortex C-terminal pleckstrin homology GO:0032065//GO:0007165 cortical protein anchoring//signal transduction GO:0005158//GO:0005543//GO:0005515 insulin receptor binding//phospholipid binding//protein binding GO:0005938//GO:0005899 cell cortex//insulin receptor complex -- -- Cluster-8309.25180 BF_2 79.23 2.22 1779 642911571 XP_008199480.1 1974 1.5e-218 PREDICTED: solute carrier family 41 member 1-like [Tribolium castaneum] 642911570 XM_008201258.1 420 0 PREDICTED: Tribolium castaneum solute carrier family 41 member 1-like (LOC662863), mRNA K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1136 8.9e-123 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF04093 Divalent cation transporter//rod shape-determining protein MreD GO:0008360//GO:0006812 regulation of cell shape//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3788 Predicted divalent cation transporter Cluster-8309.25183 BF_2 368.37 3.31 4945 478254843 ENN75079.1 2366 1.4e-263 hypothetical protein YQE_08392, partial [Dendroctonus ponderosae]>gi|546676933|gb|ERL87857.1| hypothetical protein D910_05245 [Dendroctonus ponderosae] 611988503 XM_007481079.1 72 2.12563e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 1364 9.0e-149 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF13180//PF00595//PF08001//PF00610//PF02273 PDZ domain//PDZ domain (Also known as DHR or GLGF)//CMV US//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Acyl transferase GO:0006631//GO:0030683//GO:0035556 fatty acid metabolic process//evasion or tolerance by virus of host immune response//intracellular signal transduction GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0044386 integral to host endoplasmic reticulum membrane KOG3571 Dishevelled 3 and related proteins Cluster-8309.25184 BF_2 62.13 0.56 4966 642926739 XP_008194992.1 2365 1.9e-263 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X2 [Tribolium castaneum] 611988503 XM_007481079.1 71 7.67784e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 1368 3.1e-149 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF02273//PF00610//PF08001//PF00595//PF13180 Acyl transferase//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//CMV US//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006631//GO:0030683//GO:0035556 fatty acid metabolic process//evasion or tolerance by virus of host immune response//intracellular signal transduction GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0044386 integral to host endoplasmic reticulum membrane KOG3571 Dishevelled 3 and related proteins Cluster-8309.25186 BF_2 295.32 4.10 3299 91084581 XP_973970.1 1723 3.5e-189 PREDICTED: signal peptide peptidase-like 3 isoform X1 [Tribolium castaneum]>gi|270008893|gb|EFA05341.1| hypothetical protein TcasGA2_TC015505 [Tribolium castaneum] 27820031 BT003288.1 200 9.89246e-98 Drosophila melanogaster GM06145 full insert cDNA K09598 SPPL3 signal peptide peptidase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09598 Q9CUS9 1217 6.7e-132 Signal peptide peptidase-like 3 OS=Mus musculus GN=Sppl3 PE=1 SV=3 PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.25188 BF_2 8.17 0.60 856 282158097 NP_001164092.1 284 6.5e-23 quaking related [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02289 Cyclohydrolase (MCH) GO:0006730//GO:0006807//GO:0046656 one-carbon metabolic process//nitrogen compound metabolic process//folic acid biosynthetic process GO:0018759 methenyltetrahydromethanopterin cyclohydrolase activity -- -- -- -- Cluster-8309.25189 BF_2 272.72 6.34 2087 91077770 XP_968734.1 884 4.2e-92 PREDICTED: phospholipase B1, membrane-associated [Tribolium castaneum]>gi|270001499|gb|EEZ97946.1| hypothetical protein TcasGA2_TC000336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q06HQ7 466 5.1e-45 Phospholipase B1, membrane-associated OS=Monodelphis domestica GN=PLB1 PE=2 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.2519 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25191 BF_2 86.59 1.23 3223 546681602 ERL91666.1 610 3.9e-60 hypothetical protein D910_08994 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZLX5 417 3.8e-39 Zinc finger Ran-binding domain-containing protein 2 OS=Gallus gallus GN=ZRANB2 PE=2 SV=1 PF02535//PF00641//PF00628//PF01080 ZIP Zinc transporter//Zn-finger in Ran binding protein and others//PHD-finger//Presenilin GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0008270//GO:0046873//GO:0004190//GO:0005515 zinc ion binding//metal ion transmembrane transporter activity//aspartic-type endopeptidase activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1995 Conserved Zn-finger protein Cluster-8309.25192 BF_2 358.41 5.58 2976 546681602 ERL91666.1 610 3.6e-60 hypothetical protein D910_08994 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZLX5 417 3.5e-39 Zinc finger Ran-binding domain-containing protein 2 OS=Gallus gallus GN=ZRANB2 PE=2 SV=1 PF01080//PF00628//PF00641//PF02535 Presenilin//PHD-finger//Zn-finger in Ran binding protein and others//ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0004190//GO:0005515//GO:0046873//GO:0008270 aspartic-type endopeptidase activity//protein binding//metal ion transmembrane transporter activity//zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1995 Conserved Zn-finger protein Cluster-8309.25193 BF_2 215.00 9.17 1268 91076844 XP_974775.1 912 1.5e-95 PREDICTED: probable enoyl-CoA hydratase, mitochondrial [Tribolium castaneum]>gi|270001819|gb|EEZ98266.1| hypothetical protein TcasGA2_TC000708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1ZXF1 301 4.2e-26 Probable enoyl-CoA hydratase, mitochondrial OS=Dictyostelium discoideum GN=echs1 PE=3 SV=1 PF00378//PF16113//PF11429//PF01343 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//Colicin D//Peptidase family S49 GO:0008152//GO:0006508//GO:0051252 metabolic process//proteolysis//regulation of RNA metabolic process GO:0003824//GO:0016836//GO:0008233//GO:0004540 catalytic activity//hydro-lyase activity//peptidase activity//ribonuclease activity -- -- KOG1680 Enoyl-CoA hydratase Cluster-8309.25196 BF_2 197.22 2.39 3742 270001216 EEZ97663.1 4142 0.0e+00 hypothetical protein TcasGA2_TC016208 [Tribolium castaneum] 820865686 XM_012493878.1 479 0 PREDICTED: Apis florea ribonuclease 3 (LOC100863432), mRNA K03685 rnc, DROSHA, RNT1 ribonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K03685 Q9NRR4 2614 7.8e-294 Ribonuclease 3 OS=Homo sapiens GN=DROSHA PE=1 SV=2 PF00636//PF14622 Ribonuclease III domain//Ribonuclease-III-like GO:0051252//GO:0006396 regulation of RNA metabolic process//RNA processing GO:0003723//GO:0004525 RNA binding//ribonuclease III activity -- -- KOG1817 Ribonuclease Cluster-8309.25197 BF_2 92.18 1.39 3070 189233949 XP_001815164.1 2337 2.0e-260 PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911540|ref|XP_008199465.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911543|ref|XP_008199466.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum] 808116654 XM_012320378.1 112 7.63191e-49 PREDICTED: Bombus terrestris striatin-interacting protein 1 (LOC100642989), transcript variant X2, mRNA -- -- -- -- Q0P5J8 1890 5.7e-210 Striatin-interacting protein 1 OS=Bos taurus GN=STRIP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3680 Uncharacterized conserved protein Cluster-8309.25199 BF_2 335.07 4.42 3458 91090880 XP_973129.1 851 4.7e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.25200 BF_2 113.17 1.46 3527 91090880 XP_973129.1 851 4.8e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.25203 BF_2 57.53 1.18 2333 91091704 XP_972821.1 1621 1.6e-177 PREDICTED: phosphatidylinositol 4-kinase beta [Tribolium castaneum]>gi|270001265|gb|EEZ97712.1| four wheel drive [Tribolium castaneum] 156717327 NM_001102734.1 64 2.78713e-22 Xenopus (Silurana) tropicalis phosphatidylinositol 4-kinase, catalytic, beta (pi4kb), mRNA >gnl|BL_ORD_ID|3952838 Xenopus tropicalis phosphatidylinositol 4-kinase, catalytic, beta, mRNA (cDNA clone MGC:122410 IMAGE:7649711), complete cds K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 B4UT09 690 6.1e-71 Phosphatidylinositol 4-kinase beta OS=Otolemur garnettii GN=PI4KB PE=3 SV=1 PF08288//PF07415 PIGA (GPI anchor biosynthesis)//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042//GO:0006506//GO:0006796 viral latency//GPI anchor biosynthetic process//phosphate-containing compound metabolic process GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0033644 host cell membrane KOG0903 Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion Cluster-8309.25205 BF_2 64.79 2.37 1431 642914885 XP_008190430.1 598 4.2e-59 PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914887|ref|XP_008190431.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914889|ref|XP_008190432.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 333 9.3e-30 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25206 BF_2 2.41 0.36 568 478259535 ENN79399.1 204 8.1e-14 hypothetical protein YQE_04149, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07962 Replication Fork Protection Component Swi3 GO:0007049//GO:0006974//GO:0048478 cell cycle//cellular response to DNA damage stimulus//replication fork protection -- -- GO:0005634 nucleus -- -- Cluster-8309.25207 BF_2 111.33 3.36 1673 189234930 XP_971266.2 529 5.0e-51 PREDICTED: CTL-like protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 331 1.9e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25208 BF_2 14.00 1.23 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25209 BF_2 160.69 2.34 3160 642914891 XP_008190433.1 1677 7.1e-184 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] 620966641 XM_007658441.1 44 4.96959e-11 PREDICTED: Ornithorhynchus anatinus choline transporter-like protein 2 (LOC100086451), mRNA K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 1269 6.0e-138 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25210 BF_2 20.82 1.83 762 642914891 XP_008190433.1 586 5.5e-58 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 337 1.7e-30 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25211 BF_2 5.90 0.39 913 642914885 XP_008190430.1 598 2.7e-59 PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914887|ref|XP_008190431.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum]>gi|642914889|ref|XP_008190432.1| PREDICTED: CTL-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 333 5.9e-30 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25212 BF_2 43.93 0.73 2789 642914891 XP_008190433.1 1675 1.1e-183 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] 620966641 XM_007658441.1 44 4.37941e-11 PREDICTED: Ornithorhynchus anatinus choline transporter-like protein 2 (LOC100086451), mRNA K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 1269 5.3e-138 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.25213 BF_2 33.69 0.66 2410 270002312 EEZ98759.1 468 8.5e-44 hypothetical protein TcasGA2_TC001323 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 331 2.7e-29 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 PF07962 Replication Fork Protection Component Swi3 GO:0007049//GO:0006974//GO:0048478 cell cycle//cellular response to DNA damage stimulus//replication fork protection -- -- GO:0005634 nucleus KOG1362 Choline transporter-like protein Cluster-8309.25217 BF_2 151.62 1.55 4392 642936679 XP_008198534.1 629 3.3e-62 PREDICTED: protein rhomboid isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20350 202 4.4e-14 Protein rhomboid OS=Drosophila melanogaster GN=rho PE=1 SV=2 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.2522 BF_2 50.00 2.70 1062 751441644 XP_011195425.1 150 2.8e-07 PREDICTED: extensin [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25221 BF_2 61.46 0.63 4362 817324046 XP_012332723.1 243 1.9e-17 PREDICTED: zinc finger protein 808, partial [Aotus nancymaae] 642918101 XM_008195799.1 403 0 PREDICTED: Tribolium castaneum Krueppel-like factor 6 (LOC103313193), transcript variant X1, mRNA K09206 KLF5 krueppel-like factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09206 Q5VIY5 232 1.5e-17 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13465//PF00096//PF13912//PF15060//PF10232//PF00471 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Differentiation and proliferation regulator//Mediator of RNA polymerase II transcription complex subunit 8//Ribosomal protein L33 GO:0030154//GO:0006357//GO:0042254//GO:0007275//GO:0006412 cell differentiation//regulation of transcription from RNA polymerase II promoter//ribosome biogenesis//multicellular organismal development//translation GO:0003735//GO:0046872//GO:0001104 structural constituent of ribosome//metal ion binding//RNA polymerase II transcription cofactor activity GO:0005622//GO:0005840//GO:0016592 intracellular//ribosome//mediator complex -- -- Cluster-8309.25227 BF_2 20.00 0.70 1484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00148//PF02075//PF06756 Nitrogenase component 1 type Oxidoreductase//Crossover junction endodeoxyribonuclease RuvC//Chorion protein S19 C-terminal GO:0006308//GO:0055114//GO:0006310//GO:0006281//GO:0007275 DNA catabolic process//oxidation-reduction process//DNA recombination//DNA repair//multicellular organismal development GO:0004520//GO:0016491 endodeoxyribonuclease activity//oxidoreductase activity GO:0042600 chorion -- -- Cluster-8309.25228 BF_2 26.86 5.46 493 478258085 ENN78223.1 250 3.3e-19 hypothetical protein YQE_05375, partial [Dendroctonus ponderosae]>gi|546682769|gb|ERL92658.1| hypothetical protein D910_09971 [Dendroctonus ponderosae] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 Q9WUB4 207 1.3e-15 Dynactin subunit 6 OS=Mus musculus GN=Dctn6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25229 BF_2 195.00 7.09 1437 270009554 EFA06002.1 908 4.8e-95 hypothetical protein TcasGA2_TC008828 [Tribolium castaneum] -- -- -- -- -- K08742 SIAH2 E3 ubiquitin-protein ligase SIAH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08742 A8X679 283 5.9e-24 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF00097//PF03145//PF02891//PF14634//PF15965 Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//MIZ/SP-RING zinc finger//zinc-RING finger domain//TRAF-like zinc-finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.25232 BF_2 637.23 10.73 2772 640802703 XP_008057688.1 799 4.0e-82 PREDICTED: zinc finger protein 658B-like [Tarsius syrichta] -- -- -- -- -- -- -- -- -- Q14590 778 4.5e-81 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF07776//PF16622//PF13912//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25234 BF_2 476.74 9.13 2472 332375390 AEE62836.1 714 2.6e-72 unknown [Dendroctonus ponderosae]>gi|478257091|gb|ENN77254.1| hypothetical protein YQE_06083, partial [Dendroctonus ponderosae] -- -- -- -- -- K07860 RAC2 Ras-related C3 botulinum toxin substrate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07860 Q24192 512 2.8e-50 Ras-like GTP-binding protein RhoL OS=Drosophila melanogaster GN=RhoL PE=2 SV=1 PF07361//PF00071//PF04210//PF04513//PF08653//PF03205//PF00025//PF08477//PF01926 Cytochrome b562//Ras family//Tetrahydromethanopterin S-methyltransferase, subunit G//Baculovirus polyhedron envelope protein, PEP, C terminus//DASH complex subunit Dam1//Molybdopterin guanine dinucleotide synthesis protein B//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0046656//GO:0008608//GO:0022900//GO:0006118//GO:0006777//GO:0015948//GO:0007264 folic acid biosynthetic process//attachment of spindle microtubules to kinetochore//electron transport chain//obsolete electron transport//Mo-molybdopterin cofactor biosynthetic process//methanogenesis//small GTPase mediated signal transduction GO:0030269//GO:0005198//GO:0005506//GO:0009055//GO:0005525//GO:0020037 tetrahydromethanopterin S-methyltransferase activity//structural molecule activity//iron ion binding//electron carrier activity//GTP binding//heme binding GO:0019028//GO:0016021//GO:0042729//GO:0042597//GO:0072686//GO:0019031 viral capsid//integral component of membrane//DASH complex//periplasmic space//mitotic spindle//viral envelope KOG0393 Ras-related small GTPase, Rho type Cluster-8309.25239 BF_2 244.22 2.70 4078 642920177 XP_008192234.1 3447 0.0e+00 PREDICTED: echinoderm microtubule-associated protein-like 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K18595 EML1_2 echinoderm microtubule-associated protein-like 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18595 Q4V8C3 1933 7.8e-215 Echinoderm microtubule-associated protein-like 1 OS=Rattus norvegicus GN=Eml1 PE=2 SV=2 PF00930//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains Cluster-8309.25243 BF_2 17.32 0.35 2357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25245 BF_2 17.30 0.73 1275 91080995 XP_975051.1 207 8.2e-14 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 611973182 XM_007473479.1 35 1.98719e-06 PREDICTED: Monodelphis domestica tudor domain containing 9 (TDRD9), mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 -- -- -- -- -- -- GO:0006457 protein folding GO:0005509//GO:0051082 calcium ion binding//unfolded protein binding GO:0005783 endoplasmic reticulum -- -- Cluster-8309.25247 BF_2 130.16 4.38 1531 642911933 XP_008199027.1 769 6.7e-79 PREDICTED: transmembrane protein 199 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N511 221 9.7e-17 Transmembrane protein 199 OS=Homo sapiens GN=TMEM199 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25249 BF_2 92.27 1.23 3435 642930234 XP_008196310.1 630 2.0e-62 PREDICTED: unc-112-related protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 369 1.5e-33 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.2525 BF_2 27.24 0.44 2874 642923363 XP_008193718.1 2243 1.5e-249 PREDICTED: kinesin-like protein KIF14 [Tribolium castaneum]>gi|270008161|gb|EFA04609.1| nebbish [Tribolium castaneum] -- -- -- -- -- K17915 KIF14 kinesin family member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K17915 L0N7N1 920 1.6e-97 Kinesin-like protein KIF14 OS=Mus musculus GN=Kif14 PE=1 SV=1 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0003777//GO:0005524//GO:0000166//GO:0008017 microtubule motor activity//ATP binding//nucleotide binding//microtubule binding GO:0005874//GO:0044430//GO:0015630//GO:0045298//GO:0043234 microtubule//cytoskeletal part//microtubule cytoskeleton//tubulin complex//protein complex KOG0241 Kinesin-like protein Cluster-8309.25251 BF_2 22.33 3.91 526 675878356 XP_009024738.1 727 1.7e-74 hypothetical protein HELRODRAFT_155129 [Helobdella robusta]>gi|675883990|ref|XP_009027497.1| hypothetical protein HELRODRAFT_185105 [Helobdella robusta]>gi|675883992|ref|XP_009027498.1| hypothetical protein HELRODRAFT_185110 [Helobdella robusta]>gi|555691200|gb|ESN94432.1| hypothetical protein HELRODRAFT_185105 [Helobdella robusta]>gi|555691201|gb|ESN94433.1| hypothetical protein HELRODRAFT_185110 [Helobdella robusta]>gi|555694029|gb|ESN97261.1| hypothetical protein HELRODRAFT_155129 [Helobdella robusta] 823672677 KR711168.1 297 1.78617e-152 Synthetic construct Homo sapiens clone CCSBHm_00020922 ACTG1 (ACTG1) mRNA, encodes complete protein K12315 ACTG2 actin, gamma-enteric smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12315 Q964E0 724 1.6e-75 Actin, cytoplasmic OS=Biomphalaria tenagophila PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.25255 BF_2 121.75 1.46 3774 91081335 XP_967042.1 5001 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X2 [Tribolium castaneum]>gi|270005182|gb|EFA01630.1| hypothetical protein TcasGA2_TC007200 [Tribolium castaneum] 820837636 XM_012494483.1 538 0 PREDICTED: Apis florea probable phosphorylase b kinase regulatory subunit alpha (LOC100865608), transcript variant X3, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 4145 0.0e+00 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 PF07525 SOCS box GO:0005977//GO:0005975//GO:0035556 glycogen metabolic process//carbohydrate metabolic process//intracellular signal transduction GO:0004553//GO:0005516 hydrolase activity, hydrolyzing O-glycosyl compounds//calmodulin binding -- -- KOG3635 Phosphorylase kinase Cluster-8309.25258 BF_2 319.80 4.01 3626 642935103 XP_008197888.1 1698 3.0e-186 PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935105|ref|XP_008197889.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935107|ref|XP_008197890.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935109|ref|XP_008197891.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935111|ref|XP_008197892.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.25259 BF_2 217.71 9.11 1287 642929434 XP_008195838.1 963 1.8e-101 PREDICTED: transcription initiation factor TFIID subunit 8-like [Tribolium castaneum]>gi|270010530|gb|EFA06978.1| hypothetical protein TcasGA2_TC009938 [Tribolium castaneum] -- -- -- -- -- K14649 TAF8 transcription initiation factor TFIID subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14649 Q9VWY6 520 1.7e-51 Transcription initiation factor TFIID subunit 8 OS=Drosophila melanogaster GN=Taf8 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25260 BF_2 145.46 2.59 2636 189235061 XP_001814285.1 1484 1.4e-161 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1YF12 319 7.2e-28 Zinc finger protein 16 OS=Gorilla gorilla gorilla GN=ZNF16 PE=3 SV=1 PF13465//PF00096//PF10588 Zinc-finger double domain//Zinc finger, C2H2 type//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114 oxidation-reduction process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.25263 BF_2 20.00 7.80 393 524993224 XP_005044453.1 145 3.9e-07 PREDICTED: sperm acrosomal protein FSA-ACR.1-like [Ficedula albicollis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06379//PF06403 L-rhamnose-proton symport protein (RhaT)//Lamprin GO:0015762//GO:0008645 rhamnose transport//hexose transport GO:0015153//GO:0005198 rhamnose transmembrane transporter activity//structural molecule activity GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane -- -- Cluster-8309.25266 BF_2 773.00 28.70 1414 270010967 EFA07415.1 1039 3.0e-110 brain peptide ITGQGNRIF-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P85828 675 2.0e-69 Prohormone-3 OS=Apis mellifera PE=1 SV=1 PF04706//PF07740 Dickkopf N-terminal cysteine-rich region//Ion channel inhibitory toxin GO:0006810//GO:0007275//GO:0030178//GO:0009405 transport//multicellular organismal development//negative regulation of Wnt signaling pathway//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.25267 BF_2 130.09 1.59 3715 642934618 XP_008197739.1 2979 0.0e+00 PREDICTED: zinc finger protein 62-like [Tribolium castaneum]>gi|270013744|gb|EFA10192.1| hypothetical protein TcasGA2_TC012384 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05481 443 4.2e-42 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25269 BF_2 128.35 5.29 1303 642911417 XP_008199414.1 1498 1.7e-163 PREDICTED: arrestin domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911416 XM_008201192.1 317 3.50753e-163 PREDICTED: Tribolium castaneum arrestin domain-containing protein 2 (LOC661443), transcript variant X1, mRNA -- -- -- -- Q8TBH0 268 2.9e-22 Arrestin domain-containing protein 2 OS=Homo sapiens GN=ARRDC2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.25270 BF_2 334.36 11.97 1456 270297178 NP_001161915.1 962 2.7e-101 cuticular protein analogous to peritrophins 3-E [Tribolium castaneum]>gi|268309024|gb|ACY95478.1| cuticular protein analogous to peritrophins 3-E [Tribolium castaneum]>gi|270001058|gb|EEZ97505.1| hypothetical protein TcasGA2_TC011349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8XWX5 163 4.9e-10 Chondroitin proteoglycan 2 OS=Caenorhabditis briggsae GN=cpg-2 PE=3 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.25272 BF_2 27.38 0.62 2128 642920497 XP_008192376.1 2163 2.1e-240 PREDICTED: head-specific guanylate cyclase [Tribolium castaneum]>gi|270005900|gb|EFA02348.1| hypothetical protein TcasGA2_TC008018 [Tribolium castaneum] 755945261 XM_011301432.1 167 1.40343e-79 PREDICTED: Fopius arisanus head-specific guanylate cyclase (LOC105264506), mRNA K12318 GUCY1A guanylate cyclase soluble subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K12318 Q07093 1582 2.0e-174 Head-specific guanylate cyclase OS=Drosophila melanogaster GN=Gycalpha99B PE=2 SV=2 PF07700//PF00211//PF07701//PF00522 Haem-NO-binding//Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated//VPR/VPX protein GO:0009190//GO:0035556//GO:0019058//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//viral life cycle//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0020037//GO:0004383//GO:0000166 phosphorus-oxygen lyase activity//heme binding//guanylate cyclase activity//nucleotide binding GO:0005622//GO:0042025 intracellular//host cell nucleus KOG4171 Adenylate/guanylate kinase Cluster-8309.25275 BF_2 38.79 0.63 2870 91094595 XP_970633.1 778 1.1e-79 PREDICTED: cytochrome P450 6k1 [Tribolium castaneum]>gi|270016411|gb|EFA12857.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q964R0 481 1.3e-46 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0005488//GO:0016705 heme binding//oxidoreductase activity//iron ion binding//binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.25279 BF_2 289.17 3.39 3852 478254444 ENN74696.1 1939 3.6e-214 hypothetical protein YQE_08813, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIL5 988 2.8e-105 Beta-galactosidase-1-like protein 3 OS=Rattus norvegicus GN=Glb1l3 PE=2 SV=1 PF00560//PF02449//PF13855//PF00150 Leucine Rich Repeat//Beta-galactosidase//Leucine rich repeat//Cellulase (glycosyl hydrolase family 5) GO:0006027//GO:0006012//GO:0046486//GO:0005975//GO:0006687 glycosaminoglycan catabolic process//galactose metabolic process//glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process GO:0005515//GO:0004565//GO:0004553 protein binding//beta-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.2528 BF_2 41.00 1.21 1705 478253720 ENN74019.1 1319 1.3e-142 hypothetical protein YQE_09409, partial [Dendroctonus ponderosae]>gi|546685011|gb|ERL94576.1| hypothetical protein D910_11853 [Dendroctonus ponderosae] -- -- -- -- -- K15102 SLC25A3, PHC, PIC solute carrier family 25 (mitochondrial phosphate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15102 P12234 1093 8.3e-118 Phosphate carrier protein, mitochondrial OS=Bos taurus GN=SLC25A3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0767 Mitochondrial phosphate carrier protein Cluster-8309.25280 BF_2 129.74 1.40 4177 546679018 ERL89541.1 1939 3.9e-214 hypothetical protein D910_06906 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIL5 988 3.0e-105 Beta-galactosidase-1-like protein 3 OS=Rattus norvegicus GN=Glb1l3 PE=2 SV=1 PF00150//PF13855//PF02449//PF00560 Cellulase (glycosyl hydrolase family 5)//Leucine rich repeat//Beta-galactosidase//Leucine Rich Repeat GO:0005975//GO:0046486//GO:0006687//GO:0006027//GO:0006012 carbohydrate metabolic process//glycerolipid metabolic process//glycosphingolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process GO:0005515//GO:0004565//GO:0004553 protein binding//beta-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.25281 BF_2 736.72 15.40 2288 642920410 XP_008192336.1 513 4.9e-49 PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum]>gi|642920412|ref|XP_008192337.1| PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum]>gi|642920414|ref|XP_008192338.1| PREDICTED: DNA-directed RNA polymerase I subunit rpa1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25285 BF_2 59.97 0.40 6628 675379920 KFM72822.1 1258 5.8e-135 Transposable element P transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF08558//PF07967 THAP domain//Telomere repeat binding factor (TRF)//C3HC zinc finger-like -- -- GO:0042162//GO:0003676//GO:0042803//GO:0008270 telomeric DNA binding//nucleic acid binding//protein homodimerization activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25286 BF_2 223.00 36.59 542 642920788 XP_008192561.1 402 8.5e-37 PREDICTED: cholinephosphotransferase 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q4KLV1 262 6.0e-22 Cholinephosphotransferase 1 OS=Xenopus laevis GN=chpt1 PE=2 SV=1 PF01066 CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.25289 BF_2 99.08 2.05 2306 642928571 XP_008199962.1 982 2.0e-103 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q7ZV22 906 5.4e-96 S-methyl-5'-thioadenosine phosphorylase OS=Danio rerio GN=mtap PE=2 SV=2 PF09242//PF01048 Flavocytochrome c sulphide dehydrogenase, flavin-binding//Phosphorylase superfamily GO:0055114//GO:0009116 oxidation-reduction process//nucleoside metabolic process GO:0016491//GO:0003824//GO:0050660 oxidoreductase activity//catalytic activity//flavin adenine dinucleotide binding -- -- KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.25291 BF_2 30.88 0.60 2457 91087699 XP_974256.1 900 6.9e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 4.8e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417//GO:0016740 fucosyltransferase activity//transferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.25292 BF_2 128.17 1.56 3725 270001422 EEZ97869.1 1064 1.0e-112 hypothetical protein TcasGA2_TC000244 [Tribolium castaneum] 642914786 XM_008192130.1 634 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 O43679 846 7.9e-89 LIM domain-binding protein 2 OS=Homo sapiens GN=LDB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.25293 BF_2 263.00 8.52 1578 646696178 KDR08625.1 1853 1.4e-204 LIM domain-binding protein 2, partial [Zootermopsis nevadensis] 642914784 XM_008192129.1 618 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X6, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 Q9W676 1343 7.9e-147 LIM domain-binding protein 2 OS=Gallus gallus GN=LDB2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.25299 BF_2 220.91 5.86 1863 642927330 XP_008195223.1 1284 1.6e-138 PREDICTED: STE20-related kinase adapter protein alpha [Tribolium castaneum] -- -- -- -- -- K08271 STRADA, LYK5 STE20-related kinase adapter protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08271 Q5ZK47 623 2.9e-63 STE20-related kinase adapter protein alpha OS=Gallus gallus GN=STRADA PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0582 Ste20-like serine/threonine protein kinase Cluster-8309.25300 BF_2 24.72 0.31 3645 91085763 XP_974155.1 1774 4.7e-195 PREDICTED: polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270009999|gb|EFA06447.1| hypothetical protein TcasGA2_TC009329 [Tribolium castaneum] -- -- -- -- -- K00962 pnp, PNPT1 polyribonucleotide nucleotidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00962 Q8K1R3 1204 2.4e-130 Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Mus musculus GN=Pnpt1 PE=1 SV=1 PF00013//PF00575//PF03726//PF03171 KH domain//S1 RNA binding domain//Polyribonucleotide nucleotidyltransferase, RNA binding domain//2OG-Fe(II) oxygenase superfamily GO:0006402//GO:0006144//GO:0006206//GO:0051252//GO:0006396//GO:0055114 mRNA catabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//regulation of RNA metabolic process//RNA processing//oxidation-reduction process GO:0000175//GO:0003723//GO:0004654//GO:0016491//GO:0003676 3'-5'-exoribonuclease activity//RNA binding//polyribonucleotide nucleotidyltransferase activity//oxidoreductase activity//nucleic acid binding -- -- KOG1067 Predicted RNA-binding polyribonucleotide nucleotidyltransferase Cluster-8309.25302 BF_2 446.07 4.74 4227 642918990 XP_008191687.1 2720 1.1e-304 PREDICTED: tyrosine-protein kinase Btk29A isoform X1 [Tribolium castaneum]>gi|270005708|gb|EFA02156.1| hypothetical protein TcasGA2_TC007809 [Tribolium castaneum] 642918993 XM_008193468.1 431 0 PREDICTED: Tribolium castaneum tyrosine-protein kinase Btk29A (LOC663266), transcript variant X3, mRNA K07364 TEC tyrosine-protein kinase Tec http://www.genome.jp/dbget-bin/www_bget?ko:K07364 P08630 1986 5.8e-221 Tyrosine-protein kinase Btk29A OS=Drosophila melanogaster GN=Btk29A PE=2 SV=2 PF00779//PF00069//PF14604//PF00018//PF07714 BTK motif//Protein kinase domain//Variant SH3 domain//SH3 domain//Protein tyrosine kinase GO:0006468//GO:0035556 protein phosphorylation//intracellular signal transduction GO:0004713//GO:0005524//GO:0005543//GO:0005515//GO:0004672 protein tyrosine kinase activity//ATP binding//phospholipid binding//protein binding//protein kinase activity GO:0005622 intracellular -- -- Cluster-8309.25303 BF_2 4.01 0.81 494 270015441 EFA11889.1 233 3.1e-17 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25306 BF_2 49.19 1.45 1702 642910205 XP_008198403.1 352 1.7e-30 PREDICTED: NF-kappa-B-repressing factor-like [Tribolium castaneum]>gi|270014634|gb|EFA11082.1| hypothetical protein TcasGA2_TC004678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15226 145 7.0e-08 NF-kappa-B-repressing factor OS=Homo sapiens GN=NKRF PE=1 SV=2 PF01585//PF01424 G-patch domain//R3H domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.25307 BF_2 11.00 0.53 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25309 BF_2 23.28 1.99 776 332373772 AEE62027.1 692 2.9e-70 unknown [Dendroctonus ponderosae]>gi|478252497|gb|ENN72919.1| hypothetical protein YQE_10486, partial [Dendroctonus ponderosae]>gi|546679961|gb|ERL90331.1| hypothetical protein D910_07680 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16326//PF05531//PF04353//PF05837//PF08702 ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family GO:0006355//GO:0030168//GO:0007165//GO:0051382//GO:0051258 regulation of transcription, DNA-templated//platelet activation//signal transduction//kinetochore assembly//protein polymerization GO:0030674//GO:0005102//GO:0003677 protein binding, bridging//receptor binding//DNA binding GO:0000776//GO:0005577//GO:0019028 kinetochore//fibrinogen complex//viral capsid -- -- Cluster-8309.25310 BF_2 253.72 24.92 713 332373772 AEE62027.1 664 4.7e-67 unknown [Dendroctonus ponderosae]>gi|478252497|gb|ENN72919.1| hypothetical protein YQE_10486, partial [Dendroctonus ponderosae]>gi|546679961|gb|ERL90331.1| hypothetical protein D910_07680 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702//PF04353//PF05837//PF05531//PF16326 Fibrinogen alpha/beta chain family//Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ//Centromere protein H (CENP-H)//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain GO:0007165//GO:0051382//GO:0051258//GO:0030168//GO:0006355 signal transduction//kinetochore assembly//protein polymerization//platelet activation//regulation of transcription, DNA-templated GO:0003677//GO:0005102//GO:0030674 DNA binding//receptor binding//protein binding, bridging GO:0019028//GO:0000776//GO:0005577 viral capsid//kinetochore//fibrinogen complex -- -- Cluster-8309.25314 BF_2 561.56 6.27 4033 642936684 XP_001807897.2 1937 6.5e-214 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] 755863466 XM_005179480.2 52 2.27074e-15 PREDICTED: Musca domestica uncharacterized LOC101889854 (LOC101889854), mRNA -- -- -- -- Q23435 273 2.4e-22 TWiK family of potassium channels protein 9 OS=Caenorhabditis elegans GN=twk-9 PE=2 SV=2 PF01007//PF00520 Inward rectifier potassium channel//Ion transport protein GO:0055085//GO:0006813//GO:0006811 transmembrane transport//potassium ion transport//ion transport GO:0005242//GO:0005216 inward rectifier potassium channel activity//ion channel activity GO:0016021//GO:0016020//GO:0008076 integral component of membrane//membrane//voltage-gated potassium channel complex -- -- Cluster-8309.25315 BF_2 161.67 9.99 964 270013109 EFA09557.1 373 3.5e-33 hypothetical protein TcasGA2_TC011669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02059 Interleukin-3 GO:0006955//GO:0008283//GO:0040007//GO:0007165 immune response//cell proliferation//growth//signal transduction GO:0005135//GO:0008083 interleukin-3 receptor binding//growth factor activity GO:0005576//GO:0005894 extracellular region//interleukin-3 receptor complex -- -- Cluster-8309.25316 BF_2 418.53 10.25 1995 332375789 AEE63035.1 1293 1.5e-139 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DJ55 342 1.2e-30 Protein TBRG4 OS=Xenopus tropicalis GN=tbrg4 PE=2 SV=2 PF06743 FAST kinase-like protein, subdomain 1 -- -- GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.25317 BF_2 189.12 5.96 1615 642936684 XP_001807897.2 994 5.8e-105 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] 755863466 XM_005179480.2 52 8.97899e-16 PREDICTED: Musca domestica uncharacterized LOC101889854 (LOC101889854), mRNA -- -- -- -- Q18120 259 4.0e-21 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF01007//PF00060//PF00520 Inward rectifier potassium channel//Ligand-gated ion channel//Ion transport protein GO:0007268//GO:0006813//GO:0007165//GO:0055085//GO:0006811 synaptic transmission//potassium ion transport//signal transduction//transmembrane transport//ion transport GO:0005242//GO:0004970//GO:0005216 inward rectifier potassium channel activity//ionotropic glutamate receptor activity//ion channel activity GO:0016021//GO:0008076//GO:0016020 integral component of membrane//voltage-gated potassium channel complex//membrane -- -- Cluster-8309.25318 BF_2 183.47 4.67 1932 332375789 AEE63035.1 1290 3.3e-139 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DJ55 342 1.1e-30 Protein TBRG4 OS=Xenopus tropicalis GN=tbrg4 PE=2 SV=2 PF06743 FAST kinase-like protein, subdomain 1 -- -- GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.25319 BF_2 408.42 4.87 3795 91079026 XP_974912.1 1817 5.0e-200 PREDICTED: rap1 GTPase-GDP dissociation stimulator 1-B [Tribolium castaneum]>gi|270003670|gb|EFA00118.1| hypothetical protein TcasGA2_TC002934 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52306 590 3.9e-59 Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens GN=RAP1GDS1 PE=1 SV=3 PF00514//PF11698 Armadillo/beta-catenin-like repeat//V-ATPase subunit H GO:0015991 ATP hydrolysis coupled proton transport GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.25322 BF_2 102.00 5.74 1031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25323 BF_2 51.99 1.14 2198 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25324 BF_2 32.05 1.45 1215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25326 BF_2 8.00 2.14 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25327 BF_2 2.92 6.15 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25328 BF_2 10.00 0.33 1551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25330 BF_2 105.27 5.10 1151 478252954 ENN73338.1 702 3.0e-71 hypothetical protein YQE_10099, partial [Dendroctonus ponderosae]>gi|546679636|gb|ERL90067.1| hypothetical protein D910_07423 [Dendroctonus ponderosae] -- -- -- -- -- K09341 MSX homeobox protein MSX http://www.genome.jp/dbget-bin/www_bget?ko:K09341 Q03372 379 3.5e-35 Muscle segmentation homeobox OS=Drosophila melanogaster GN=Dr PE=2 SV=2 PF00046//PF10538//PF05920//PF03896 Homeobox domain//Immunoreceptor tyrosine-based activation motif//Homeobox KN domain//Translocon-associated protein (TRAP), alpha subunit GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005789 endoplasmic reticulum membrane KOG0492 Transcription factor MSH, contains HOX domain Cluster-8309.25331 BF_2 586.28 6.58 4013 91082903 XP_972273.1 1219 1.2e-130 PREDICTED: uncharacterized protein LOC660988 isoform X1 [Tribolium castaneum]>gi|270007611|gb|EFA04059.1| hypothetical protein TcasGA2_TC014292 [Tribolium castaneum] -- -- -- -- -- K16731 GOLGA1 golgin subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16731 Q92805 321 6.4e-28 Golgin subfamily A member 1 OS=Homo sapiens GN=GOLGA1 PE=1 SV=3 PF01465//PF04111//PF08988 GRIP domain//Autophagy protein Apg6//Type III secretion system, cytoplasmic E component of needle GO:0006914//GO:0000042//GO:0009405 autophagy//protein targeting to Golgi//pathogenesis GO:0005515 protein binding -- -- -- -- Cluster-8309.25334 BF_2 38.51 1.13 1711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25337 BF_2 18.16 0.46 1927 642923162 XP_968605.2 1657 9.1e-182 PREDICTED: O-glucosyltransferase rumi homolog [Tribolium castaneum]>gi|270007100|gb|EFA03548.1| hypothetical protein TcasGA2_TC013552 [Tribolium castaneum] -- -- -- -- -- K13667 RUMI, KTELC1 protein glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13667 Q16QY8 1268 4.8e-138 O-glucosyltransferase rumi homolog OS=Aedes aegypti GN=AAEL011121 PE=3 SV=1 PF08152 GUCT (NUC152) domain -- -- GO:0005524//GO:0004386//GO:0003723 ATP binding//helicase activity//RNA binding GO:0005634 nucleus KOG2458 Endoplasmic reticulum protein EP58, contains filamin rod domain and KDEL motif Cluster-8309.2534 BF_2 4.00 0.47 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25341 BF_2 8.87 1.66 511 189239014 XP_974755.2 425 1.7e-39 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 178 3.1e-12 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25347 BF_2 247.34 0.97 10920 642930915 XP_008196139.1 1612 8.5e-176 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 6.2e-49 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.25351 BF_2 6.00 0.94 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25352 BF_2 1.00 2.59 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25353 BF_2 65.24 1.54 2061 642919443 XP_974536.2 1684 7.2e-185 PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum]>gi|642919445|ref|XP_008191871.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum] 158299880 XM_319893.4 393 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1509 5.8e-166 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF06221//PF08168//PF00270 Putative zinc finger motif, C2HC5-type//NUC205 domain//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0005524//GO:0003676 zinc ion binding//ATP binding//nucleic acid binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.25354 BF_2 17.63 0.54 1647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25358 BF_2 13.30 0.36 1837 270004588 EFA01036.1 633 4.7e-63 hypothetical protein TcasGA2_TC003952 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 525 6.5e-52 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25361 BF_2 133.96 1.02 5761 478261413 ENN80790.1 311 3.2e-25 hypothetical protein YQE_02799, partial [Dendroctonus ponderosae]>gi|546680986|gb|ERL91160.1| hypothetical protein D910_08500 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14895//PF07578 Protein phosphatase 1 inhibitor//Lipid A Biosynthesis N-terminal domain GO:0009245//GO:0010923 lipid A biosynthetic process//negative regulation of phosphatase activity GO:0008915//GO:0019902 lipid-A-disaccharide synthase activity//phosphatase binding -- -- -- -- Cluster-8309.25365 BF_2 26.12 1.88 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25367 BF_2 85.51 0.81 4706 642934737 XP_008197792.1 1348 1.5e-145 PREDICTED: uncharacterized protein LOC103314212 [Tribolium castaneum] 768447197 XM_011567278.1 52 2.65308e-15 PREDICTED: Plutella xylostella vegetative cell wall protein gp1 (LOC105395329), mRNA -- -- -- -- -- -- -- -- PF00057//PF00599 Low-density lipoprotein receptor domain class A//Influenza Matrix protein (M2) GO:0015992 proton transport GO:0005515//GO:0015078 protein binding//hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.25368 BF_2 34.06 0.65 2474 270013447 EFA09895.1 493 1.1e-46 hypothetical protein TcasGA2_TC012045 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00599 Influenza Matrix protein (M2) GO:0015992 proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0055036//GO:0033644 virion membrane//host cell membrane -- -- Cluster-8309.25370 BF_2 149.32 38.04 451 546683852 ERL93605.1 483 2.9e-46 hypothetical protein D910_10893 [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 433 7.4e-42 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 PF05531//PF00312 Nucleopolyhedrovirus P10 protein//Ribosomal protein S15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0019028//GO:0005840 intracellular//viral capsid//ribosome -- -- Cluster-8309.25372 BF_2 10.00 0.63 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25375 BF_2 74.53 1.17 2956 642933785 XP_008197283.1 3611 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933787|ref|XP_008197292.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933789|ref|XP_008197304.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2199 8.1e-246 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF00437//PF03193//PF00005//PF13304//PF01926//PF00664//PF01637 Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Archaeal ATPase GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0005525//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.25377 BF_2 173.69 1.03 7375 642929299 XP_008195778.1 5901 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 4266 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF00647//PF10152//PF00223//PF08040 Elongation factor 1 gamma, conserved domain//Predicted coiled-coil domain-containing protein (DUF2360)//Photosystem I psaA/psaB protein//MNLL subunit GO:0006118//GO:0006448//GO:0006414//GO:0015979 obsolete electron transport//regulation of translational elongation//translational elongation//photosynthesis GO:0003746//GO:0003954 translation elongation factor activity//NADH dehydrogenase activity GO:0071203//GO:0009579//GO:0005739//GO:0005840//GO:0009522//GO:0016021 WASH complex//thylakoid//mitochondrion//ribosome//photosystem I//integral component of membrane KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.25378 BF_2 147.00 35.51 460 546678420 ERL89043.1 260 2.1e-20 hypothetical protein D910_06421 [Dendroctonus ponderosae] -- -- -- -- -- K17436 MRPL55 large subunit ribosomal protein L55 http://www.genome.jp/dbget-bin/www_bget?ko:K17436 Q9VE04 194 3.9e-14 39S ribosomal protein L55, mitochondrial OS=Drosophila melanogaster GN=mRpL55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25382 BF_2 14.34 0.32 2167 91092792 XP_974059.1 1716 1.5e-188 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|642911515|ref|XP_008199454.1| PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|270014784|gb|EFA11232.1| hypothetical protein TcasGA2_TC010764 [Tribolium castaneum] 462386156 APGK01020335.1 242 2.90362e-121 Dendroctonus ponderosae Seq01020345, whole genome shotgun sequence K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1089 3.1e-117 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF02949//PF00515//PF13414//PF01769 7tm Odorant receptor//Tetratricopeptide repeat//TPR repeat//Divalent cation transporter GO:0007187//GO:0006812//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//cation transport//sensory perception of smell GO:0005549//GO:0005515//GO:0008324//GO:0004984 odorant binding//protein binding//cation transmembrane transporter activity//olfactory receptor activity GO:0016020 membrane KOG3788 Predicted divalent cation transporter Cluster-8309.25385 BF_2 238.00 21.56 749 642912599 XP_008200927.1 269 3.1e-21 PREDICTED: anaphase-promoting complex subunit 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9JSB3 173 1.7e-11 Anaphase-promoting complex subunit 15 OS=Xenopus tropicalis GN=anapc15 PE=2 SV=1 PF06213//PF02724//PF09421//PF15243//PF01080//PF04889//PF06524//PF04147//PF06512//PF04931 Cobalamin biosynthesis protein CobT//CDC45-like protein//Frequency clock protein//Anaphase-promoting complex subunit 15//Presenilin//Cwf15/Cwc15 cell cycle control protein//NOA36 protein//Nop14-like family//Sodium ion transport-associated//DNA polymerase phi GO:0006351//GO:0007623//GO:0006270//GO:0090266//GO:0009236//GO:0000398//GO:0006355//GO:0006814//GO:0006260 transcription, DNA-templated//circadian rhythm//DNA replication initiation//regulation of mitotic cell cycle spindle assembly checkpoint//cobalamin biosynthetic process//mRNA splicing, via spliceosome//regulation of transcription, DNA-templated//sodium ion transport//DNA replication GO:0003887//GO:0005248//GO:0003677//GO:0004190//GO:0008270 DNA-directed DNA polymerase activity//voltage-gated sodium channel activity//DNA binding//aspartic-type endopeptidase activity//zinc ion binding GO:0005681//GO:0005680//GO:0005634//GO:0042575//GO:0001518//GO:0016021//GO:0032040//GO:0005737 spliceosomal complex//anaphase-promoting complex//nucleus//DNA polymerase complex//voltage-gated sodium channel complex//integral component of membrane//small-subunit processome//cytoplasm -- -- Cluster-8309.25387 BF_2 183.00 4.96 1831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25389 BF_2 93.20 1.80 2448 270003145 EEZ99592.1 3383 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.0e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.25391 BF_2 143.61 8.93 960 478255404 ENN75626.1 421 9.5e-39 hypothetical protein YQE_07804, partial [Dendroctonus ponderosae]>gi|546675096|gb|ERL86346.1| hypothetical protein D910_03754 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 Q05713 241 2.9e-19 Alpha-crystallin B chain OS=Gallus gallus GN=CRYAB PE=2 SV=2 PF00692 dUTPase GO:0046080 dUTP metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.25392 BF_2 127.39 7.75 975 478255404 ENN75626.1 417 2.8e-38 hypothetical protein YQE_07804, partial [Dendroctonus ponderosae]>gi|546675096|gb|ERL86346.1| hypothetical protein D910_03754 [Dendroctonus ponderosae] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 Q05713 241 2.9e-19 Alpha-crystallin B chain OS=Gallus gallus GN=CRYAB PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25395 BF_2 7.00 0.32 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25397 BF_2 31.74 0.50 2928 270005301 EFA01749.1 1244 1.1e-133 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.254 BF_2 1.00 11.84 229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25404 BF_2 146.41 4.64 1608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00260 Protamine P1 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.25405 BF_2 145.78 7.98 1051 642939916 XP_973092.3 910 2.1e-95 PREDICTED: trafficking protein particle complex subunit 5 [Tribolium castaneum]>gi|270015732|gb|EFA12180.1| hypothetical protein TcasGA2_TC002333 [Tribolium castaneum] 815792880 XM_012361625.1 95 7.2187e-40 PREDICTED: Linepithema humile trafficking protein particle complex subunit 5 (LOC105668927), mRNA -- -- -- -- Q5F359 610 5.2e-62 Trafficking protein particle complex subunit 5 OS=Gallus gallus GN=TRAPPC5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3315 Transport protein particle (TRAPP) complex subunit Cluster-8309.25406 BF_2 1063.45 59.17 1039 642931405 XP_008196566.1 536 4.7e-52 PREDICTED: uncharacterized protein LOC660374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 168 9.2e-11 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25408 BF_2 341.35 9.19 1841 546673062 ERL84739.1 1005 3.5e-106 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 464 7.7e-45 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF07859//PF02230//PF00326//PF01764//PF11112//PF03583 alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3)//Pyocin activator protein PrtN//Secretory lipase GO:0046486//GO:0016042//GO:0006508//GO:0006355//GO:0006629//GO:0008152 glycerolipid metabolic process//lipid catabolic process//proteolysis//regulation of transcription, DNA-templated//lipid metabolic process//metabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.25413 BF_2 275.25 7.56 1811 642917373 XP_001806886.2 862 1.3e-89 PREDICTED: N-alpha-acetyltransferase 10 [Tribolium castaneum]>gi|270003017|gb|EEZ99464.1| hypothetical protein TcasGA2_TC000030 [Tribolium castaneum] 675300535 KM377395.1 146 5.61955e-68 Pauropsalta sp. 8 CLO-2014 acetyltransferase (ARD1) gene, partial cds K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 P41227 699 4.3e-72 N-alpha-acetyltransferase 10 OS=Homo sapiens GN=NAA10 PE=1 SV=1 PF12568//PF00583//PF13508//PF08445//PF13302//PF13673 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3235 Subunit of the major N alpha-acetyltransferase Cluster-8309.25421 BF_2 30.00 19.10 348 817061123 XP_012252151.1 212 5.9e-15 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25423 BF_2 75.00 5.47 861 154414548 XP_001580301.1 329 4.0e-28 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121914517|gb|EAY19315.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 270 1.1e-22 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.25424 BF_2 2.00 1.12 358 817061123 XP_012252151.1 200 1.5e-13 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09508 Lacto-N-biose phosphorylase -- -- GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.25425 BF_2 5.00 1.03 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25426 BF_2 35.00 3.31 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25427 BF_2 8.00 15.67 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25429 BF_2 19.63 1.47 847 668448475 KFB38130.1 166 3.1e-09 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25430 BF_2 26.00 1.43 1048 817061123 XP_012252151.1 383 2.6e-34 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03193//PF00437 Protein of unknown function, DUF258//Type II/IV secretion system protein GO:0006810 transport GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- -- -- Cluster-8309.25431 BF_2 51.00 1.32 1903 817061123 XP_012252151.1 278 7.2e-22 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00004 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.25435 BF_2 7.00 0.64 746 157106769 XP_001649474.1 200 3.1e-13 AAEL014742-PA, partial [Aedes aegypti]>gi|108868779|gb|EAT33004.1| AAEL014742-PA, partial [Aedes aegypti] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q8NB46 162 3.3e-10 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens GN=ANKRD52 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.25436 BF_2 7.00 0.55 818 123471666 XP_001319031.1 245 2.1e-18 inversin protein alternative isoform [Trichomonas vaginalis G3]>gi|121901805|gb|EAY06808.1| inversin protein alternative isoform, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q8NB46 186 5.9e-13 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Homo sapiens GN=ANKRD52 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25437 BF_2 33.89 1.69 1126 123389586 XP_001299746.1 398 5.2e-36 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121880660|gb|EAX86816.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 P16157 323 1.1e-28 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.25438 BF_2 32.00 4.07 616 817061123 XP_012252151.1 236 1.7e-17 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25439 BF_2 26.50 4.18 552 123494860 XP_001326609.1 280 1.2e-22 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q5UPA0 203 4.3e-15 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.25440 BF_2 55.39 0.59 4209 642918801 XP_008191591.1 1379 3.4e-149 PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [Tribolium castaneum]>gi|270005684|gb|EFA02132.1| hypothetical protein TcasGA2_TC007781 [Tribolium castaneum] -- -- -- -- -- K13514 LPGAT1 lysophosphatidylglycerol acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13514 Q92604 758 1.4e-78 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Homo sapiens GN=LPGAT1 PE=1 SV=1 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.25443 BF_2 16.53 0.32 2478 642928954 XP_008195631.1 832 5.4e-86 PREDICTED: checkpoint protein HUS1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H0R3 570 5.3e-57 Transmembrane protein 222 OS=Homo sapiens GN=TMEM222 PE=1 SV=2 PF04005 Hus1-like protein GO:0006281//GO:0000077 DNA repair//DNA damage checkpoint -- -- GO:0030896 checkpoint clamp complex KOG3150 Uncharacterized conserved protein Cluster-8309.25444 BF_2 53.00 2.53 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25445 BF_2 4.00 0.32 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25449 BF_2 19.00 0.45 2045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25456 BF_2 410.99 16.31 1341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25457 BF_2 771.00 7.32 4693 270007647 EFA04095.1 2932 0.0e+00 hypothetical protein TcasGA2_TC014330 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NP60 1712 3.8e-189 MOXD1 homolog 2 OS=Drosophila melanogaster GN=olf413 PE=2 SV=1 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114 oxidation-reduction process GO:0004497//GO:0016715//GO:0005507 monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-8309.25458 BF_2 465.44 38.11 798 -- -- -- -- -- 642938590 XM_008201633.1 47 2.61387e-13 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.25460 BF_2 212.90 3.10 3157 642932004 XP_008196815.1 2760 1.9e-309 PREDICTED: transducin beta-like protein 3 [Tribolium castaneum]>gi|270012271|gb|EFA08719.1| hypothetical protein TcasGA2_TC006390 [Tribolium castaneum] -- -- -- -- -- K14555 UTP13, TBL3 U3 small nucleolar RNA-associated protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14555 Q5U2W5 1299 2.0e-141 Transducin beta-like protein 3 OS=Rattus norvegicus GN=Tbl3 PE=2 SV=1 PF08625//PF07569//PF00400 Utp13 specific WD40 associated domain//TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006364//GO:0006355 rRNA processing//regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0032040 nucleus//small-subunit processome KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.25461 BF_2 203.10 3.04 3085 642932004 XP_008196815.1 2720 7.9e-305 PREDICTED: transducin beta-like protein 3 [Tribolium castaneum]>gi|270012271|gb|EFA08719.1| hypothetical protein TcasGA2_TC006390 [Tribolium castaneum] -- -- -- -- -- K14555 UTP13, TBL3 U3 small nucleolar RNA-associated protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14555 Q5U2W5 1298 2.5e-141 Transducin beta-like protein 3 OS=Rattus norvegicus GN=Tbl3 PE=2 SV=1 PF08625//PF07569//PF00400 Utp13 specific WD40 associated domain//TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006355//GO:0006364 regulation of transcription, DNA-templated//rRNA processing GO:0005515 protein binding GO:0005634//GO:0032040 nucleus//small-subunit processome KOG0319 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.25462 BF_2 37.13 0.37 4482 642925980 XP_008194717.1 1157 2.0e-123 PREDICTED: sugar phosphate exchanger 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 695 3.1e-71 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF03137//PF07690//PF02293 Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily//AmiS/UreI family transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25464 BF_2 435.32 4.52 4313 642925980 XP_008194717.1 1157 1.9e-123 PREDICTED: sugar phosphate exchanger 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 695 3.0e-71 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF02293//PF07690//PF03137 AmiS/UreI family transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25465 BF_2 291.12 6.35 2205 642925982 XP_968141.3 966 1.4e-101 PREDICTED: sugar phosphate exchanger 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 608 1.9e-61 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF02293//PF07690 AmiS/UreI family transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.25467 BF_2 45.07 0.47 4335 642931340 XP_008196537.1 877 5.7e-91 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X2 [Tribolium castaneum] 645002817 XM_008209793.1 78 8.59965e-30 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 702 4.6e-72 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.25471 BF_2 7.00 0.85 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25472 BF_2 45.00 1.17 1902 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08302 Fungal tRNA ligase phosphodiesterase domain GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation GO:0005524//GO:0003972 ATP binding//RNA ligase (ATP) activity -- -- -- -- Cluster-8309.25476 BF_2 191.12 4.00 2286 91090334 XP_966832.1 1009 1.5e-106 PREDICTED: uncharacterized protein LOC655224 [Tribolium castaneum]>gi|642934945|ref|XP_008195892.1| PREDICTED: uncharacterized protein LOC655224 [Tribolium castaneum]>gi|270013818|gb|EFA10266.1| hypothetical protein TcasGA2_TC012466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25480 BF_2 149.00 11.44 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25481 BF_2 99.41 1.10 4056 91079124 XP_975420.1 615 1.3e-60 PREDICTED: proteasome assembly chaperone 2 [Tribolium castaneum]>gi|270003633|gb|EFA00081.1| hypothetical protein TcasGA2_TC002896 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF08052//PF00096//PF07975//PF14735//PF13912//PF07776 Zinc-finger double domain//PyrBI operon leader peptide//Zinc finger, C2H2 type//TFIIH C1-like domain//HAUS augmin-like complex subunit 4//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) GO:0006281//GO:0019856//GO:0051225 DNA repair//pyrimidine nucleobase biosynthetic process//spindle assembly GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0070652//GO:0005634 HAUS complex//nucleus -- -- Cluster-8309.25484 BF_2 2.99 0.60 494 270015441 EFA11889.1 209 1.9e-14 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25485 BF_2 33.61 1.37 1317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25488 BF_2 280.00 3.13 4029 -- -- -- -- -- 642922128 XM_008194807.1 86 2.85258e-34 PREDICTED: Tribolium castaneum broad-complex core protein isoforms 1/2/3/4/5 (LOC658867), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF00951 Arterivirus GL envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.25489 BF_2 55.32 1.53 1799 91081761 XP_973104.1 642 4.2e-64 PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X1 [Tribolium castaneum]>gi|642921381|ref|XP_008192843.1| PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X1 [Tribolium castaneum]>gi|642921383|ref|XP_008192844.1| PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X1 [Tribolium castaneum]>gi|270006272|gb|EFA02720.1| hypothetical protein TcasGA2_TC008444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25490 BF_2 99.71 1.48 3101 688549951 XP_009298913.1 991 2.5e-104 PREDICTED: zinc finger protein 721-like, partial [Danio rerio] 847046770 XM_012952304.1 39 2.93444e-08 PREDICTED: Jaculus jaculus zinc finger protein 791-like (LOC101594745), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 920 1.7e-97 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF03153//PF16622//PF02487//PF01586//PF00096//PF13465 C2H2-type zinc finger//Transcription factor IIA, alpha/beta subunit//zinc-finger C2H2-type//CLN3 protein//Myogenic Basic domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007517//GO:0006355//GO:0006367 muscle organ development//regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634//GO:0016020//GO:0005672 nucleus//membrane//transcription factor TFIIA complex -- -- Cluster-8309.25491 BF_2 17.68 0.44 1977 642921385 XP_008192845.1 434 6.1e-40 PREDICTED: gastrula zinc finger protein XlCGF57.1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04989 Cephalosporin hydroxylase GO:0008610 lipid biosynthetic process GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.25492 BF_2 54.96 1.73 1614 642922123 XP_008193025.1 1626 3.0e-178 PREDICTED: broad-complex core protein isoforms 1/2/3/4/5 isoform X1 [Tribolium castaneum] 642922122 XM_008194803.1 235 1.67422e-117 PREDICTED: Tribolium castaneum broad-complex core protein isoforms 1/2/3/4/5 (LOC658867), transcript variant X1, mRNA -- -- -- -- Q9W0K7 295 2.7e-25 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF02892//PF13912//PF00651//PF01775//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//BTB/POZ domain//Ribosomal L18ae/LX protein domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003677//GO:0046872//GO:0005515 structural constituent of ribosome//DNA binding//metal ion binding//protein binding GO:0005840 ribosome -- -- Cluster-8309.25493 BF_2 116.96 3.24 1798 270008183 EFA04631.1 1602 2.0e-175 chronologically inappropriate morphogenesis [Tribolium castaneum] 642922128 XM_008194807.1 222 3.15024e-110 PREDICTED: Tribolium castaneum broad-complex core protein isoforms 1/2/3/4/5 (LOC658867), transcript variant X4, mRNA -- -- -- -- Q9W0K7 295 3.0e-25 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF00651//PF13912//PF02892//PF00096//PF13465 BTB/POZ domain//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.25494 BF_2 405.57 8.80 2216 642933721 XP_967531.2 1101 3.1e-117 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY3 673 5.4e-69 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.25497 BF_2 307.80 2.46 5523 270016078 EFA12526.1 1426 1.6e-154 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] 118441617 CR925768.9 53 8.66706e-16 Zebrafish DNA sequence from clone DKEY-20L4 in linkage group 12, complete sequence -- -- -- -- P0CT34 848 6.9e-89 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF00665//PF02793 Integrase core domain//Hormone receptor domain GO:0015074//GO:0007186 DNA integration//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.25498 BF_2 18.74 0.63 1537 642930251 XP_971223.2 984 7.9e-104 PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 132 2.0e-06 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25500 BF_2 600.00 14.27 2046 91087775 XP_976468.1 584 2.5e-57 PREDICTED: uncharacterized protein LOC663962 [Tribolium castaneum]>gi|642930537|ref|XP_008196446.1| PREDICTED: uncharacterized protein LOC663962 [Tribolium castaneum]>gi|642930539|ref|XP_008196447.1| PREDICTED: uncharacterized protein LOC663962 [Tribolium castaneum]>gi|270010748|gb|EFA07196.1| hypothetical protein TcasGA2_TC010202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25502 BF_2 27.00 2.59 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25503 BF_2 38.46 0.33 5159 478250642 ENN71134.1 2677 1.3e-299 hypothetical protein YQE_12065, partial [Dendroctonus ponderosae]>gi|546674775|gb|ERL86072.1| hypothetical protein D910_03486 [Dendroctonus ponderosae] -- -- -- -- -- K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 Q13200 1987 5.4e-221 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 PF12937//PF00328 F-box-like//Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515 acid phosphatase activity//protein binding -- -- KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.25504 BF_2 14.00 0.50 1447 662191266 XP_008468441.1 664 9.5e-67 PREDICTED: transposable element P transposase [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7M3K2 345 3.8e-31 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.25506 BF_2 83.30 0.98 3830 307170013 EFN62483.1 873 1.5e-90 Transposable element P transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q7M3K2 459 6.1e-44 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25509 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25514 BF_2 1.02 0.62 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25516 BF_2 160.16 1.34 5294 642936096 XP_008198301.1 3129 0.0e+00 PREDICTED: PR domain zinc finger protein 10-like isoform X2 [Tribolium castaneum] 780701311 XM_011703805.1 79 2.9244e-30 PREDICTED: Wasmannia auropunctata PR domain zinc finger protein 10-like (LOC105458476), transcript variant X2, mRNA -- -- -- -- Q5RAX9 917 6.6e-97 PR domain zinc finger protein 10 OS=Pongo abelii GN=PRDM10 PE=2 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25519 BF_2 93.24 0.80 5167 642930342 XP_008196356.1 1185 1.3e-126 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 374 0 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- Q8IUD2 301 1.7e-25 ELKS/Rab6-interacting/CAST family member 1 OS=Homo sapiens GN=ERC1 PE=1 SV=1 PF06156//PF16331//PF05550//PF00901//PF10174//PF07195//PF10473//PF07989//PF03836//PF08657 Protein of unknown function (DUF972)//TolA binding protein trimerisation//Pestivirus Npro endopeptidase C53//Orbivirus outer capsid protein VP5//RIM-binding protein of the cytomatrix active zone//Flagellar hook-associated protein 2 C-terminus//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//RasGAP C-terminus//DASH complex subunit Spc34 GO:0007155//GO:0007264//GO:0016032//GO:0008608//GO:0019082//GO:0006260//GO:0070206 cell adhesion//small GTPase mediated signal transduction//viral process//attachment of spindle microtubules to kinetochore//viral protein processing//DNA replication//protein trimerization GO:0042803//GO:0005096//GO:0005198//GO:0008134//GO:0045502 protein homodimerization activity//GTPase activator activity//structural molecule activity//transcription factor binding//dynein binding GO:0030286//GO:0005667//GO:0042729//GO:0009288//GO:0048786//GO:0005876//GO:0019028//GO:0005815 dynein complex//transcription factor complex//DASH complex//bacterial-type flagellum//presynaptic active zone//spindle microtubule//viral capsid//microtubule organizing center KOG4809 Rab6 GTPase-interacting protein involved in endosome-to-TGN transport Cluster-8309.25520 BF_2 993.00 25.10 1942 478257731 ENN77874.1 295 7.8e-24 hypothetical protein YQE_05552, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25526 BF_2 4.00 3.11 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25527 BF_2 255.26 1.53 7248 478254018 ENN74310.1 6609 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 242005974 XM_002423790.1 223 3.58028e-110 Pediculus humanus corporis jumonji/arid domain-containing protein, putative, mRNA K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3573 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF08429//PF01388//PF00628 PLU-1-like protein//ARID/BRIGHT DNA binding domain//PHD-finger GO:0055114 oxidation-reduction process GO:0016706//GO:0003677//GO:0005515 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//DNA binding//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.25529 BF_2 53.97 0.45 5356 642929251 XP_008195755.1 2394 8.7e-267 PREDICTED: uncharacterized protein LOC100141810 isoform X2 [Tribolium castaneum] 642929250 XM_008197533.1 85 1.36693e-33 PREDICTED: Tribolium castaneum uncharacterized LOC100141810 (LOC100141810), transcript variant X2, mRNA -- -- -- -- Q2KHR2 365 6.8e-33 DNA-binding protein RFX7 OS=Homo sapiens GN=RFX7 PE=1 SV=1 PF08917//PF06305//PF11857//PF02257 Transforming growth factor beta receptor 2 ectodomain//Protein of unknown function (DUF1049)//Domain of unknown function (DUF3377)//RFX DNA-binding domain GO:0009069//GO:0006468//GO:0016310//GO:0007178//GO:0006355 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0004222//GO:0003677//GO:0046872//GO:0005026 ATP binding//metalloendopeptidase activity//DNA binding//metal ion binding//transforming growth factor beta receptor activity, type II GO:0005887//GO:0016020 integral component of plasma membrane//membrane KOG3712 RFX family transcription factor Cluster-8309.2553 BF_2 17.44 0.54 1647 769831193 XP_011634997.1 1714 1.9e-188 PREDICTED: synaptotagmin-7 isoform X1 [Pogonomyrmex barbatus] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 5.8e-92 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.25530 BF_2 491.35 3.96 5472 642929251 XP_008195755.1 2394 8.9e-267 PREDICTED: uncharacterized protein LOC100141810 isoform X2 [Tribolium castaneum] 642929250 XM_008197533.1 85 1.39674e-33 PREDICTED: Tribolium castaneum uncharacterized LOC100141810 (LOC100141810), transcript variant X2, mRNA -- -- -- -- Q2KHR2 365 6.9e-33 DNA-binding protein RFX7 OS=Homo sapiens GN=RFX7 PE=1 SV=1 PF08917//PF11857//PF06305//PF02257 Transforming growth factor beta receptor 2 ectodomain//Domain of unknown function (DUF3377)//Protein of unknown function (DUF1049)//RFX DNA-binding domain GO:0009069//GO:0006468//GO:0016310//GO:0007178//GO:0006355 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0004222//GO:0003677//GO:0046872//GO:0005026 ATP binding//metalloendopeptidase activity//DNA binding//metal ion binding//transforming growth factor beta receptor activity, type II GO:0005887//GO:0016020 integral component of plasma membrane//membrane KOG3712 RFX family transcription factor Cluster-8309.25531 BF_2 38.68 0.44 4003 642929251 XP_008195755.1 992 2.4e-104 PREDICTED: uncharacterized protein LOC100141810 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305//PF11857//PF08917 Protein of unknown function (DUF1049)//Domain of unknown function (DUF3377)//Transforming growth factor beta receptor 2 ectodomain GO:0016310//GO:0009069//GO:0006468//GO:0007178 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0005524//GO:0004222//GO:0046872//GO:0005026 ATP binding//metalloendopeptidase activity//metal ion binding//transforming growth factor beta receptor activity, type II GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.25532 BF_2 156.00 3.16 2350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25533 BF_2 14.59 0.46 1610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25535 BF_2 34.71 0.32 4817 270297228 NP_001161905.1 496 9.6e-47 cuticular protein analogous to peritrophins 1-C precursor [Tribolium castaneum]>gi|268309004|gb|ACY95468.1| cuticular protein analogous to peritrophins 1-C [Tribolium castaneum]>gi|270001482|gb|EEZ97929.1| hypothetical protein TcasGA2_TC000316 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.25536 BF_2 44.20 5.82 605 91087535 XP_970133.1 624 1.7e-62 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] 642930219 XM_965040.2 160 2.98177e-76 PREDICTED: Tribolium castaneum DNA-directed RNA polymerases I, II, and III subunit RPABC3 (LOC658676), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 435 5.8e-42 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.25538 BF_2 120.94 2.86 2054 91077698 XP_974838.1 822 6.4e-85 PREDICTED: D-aspartate oxidase [Tribolium castaneum]>gi|270002204|gb|EEZ98651.1| hypothetical protein TcasGA2_TC001179 [Tribolium castaneum] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q922Z0 511 3.1e-50 D-aspartate oxidase OS=Mus musculus GN=Ddo PE=2 SV=1 PF01266//PF07992//PF00070 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.25539 BF_2 208.47 4.61 2177 91077698 XP_974838.1 822 6.8e-85 PREDICTED: D-aspartate oxidase [Tribolium castaneum]>gi|270002204|gb|EEZ98651.1| hypothetical protein TcasGA2_TC001179 [Tribolium castaneum] -- -- -- -- -- K00273 DAO, aao D-amino-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00273 Q922Z0 511 3.2e-50 D-aspartate oxidase OS=Mus musculus GN=Ddo PE=2 SV=1 PF00070//PF01266//PF07992 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.25540 BF_2 1.00 1.63 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25541 BF_2 57.01 0.38 6503 642924251 XP_008194216.1 4280 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] 755881777 XM_005185855.2 54 2.83883e-16 PREDICTED: Musca domestica N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (LOC101896829), transcript variant X1, mRNA K03857 PIGA, GPI3 phosphatidylinositol glycan, class A http://www.genome.jp/dbget-bin/www_bget?ko:K03857 Q64323 859 4.3e-90 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein OS=Mus musculus GN=Piga PE=2 SV=1 PF03790//PF08288//PF05112//PF02196//PF00621 KNOX1 domain//PIGA (GPI anchor biosynthesis)//Baculovirus P47 protein//Raf-like Ras-binding domain//RhoGEF domain GO:0035023//GO:0007165//GO:0046782//GO:0006506//GO:0043087 regulation of Rho protein signal transduction//signal transduction//regulation of viral transcription//GPI anchor biosynthetic process//regulation of GTPase activity GO:0005057//GO:0003677//GO:0005089 receptor signaling protein activity//DNA binding//Rho guanyl-nucleotide exchange factor activity GO:0005634 nucleus KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase Cluster-8309.25545 BF_2 16.00 0.95 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25546 BF_2 16.39 0.62 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25547 BF_2 19.49 0.58 1699 642923216 XP_008193659.1 707 1.2e-71 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K05123 ROR2, NTRKR2 receptor tyrosine kinase-like orphan receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05123 Q24488 194 1.5e-13 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.25548 BF_2 14.43 0.42 1713 642923214 XP_008193658.1 489 2.2e-46 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24488 181 4.7e-12 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25550 BF_2 620.81 6.37 4366 91092696 XP_971938.1 4030 0.0e+00 PREDICTED: trafficking protein particle complex subunit 8 [Tribolium castaneum]>gi|270014865|gb|EFA11313.1| hypothetical protein TcasGA2_TC010852 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2L5 1751 1.1e-193 Trafficking protein particle complex subunit 8 OS=Homo sapiens GN=TRAPPC8 PE=1 SV=2 PF13414//PF00515//PF00377//PF13181 TPR repeat//Tetratricopeptide repeat//Prion/Doppel alpha-helical domain//Tetratricopeptide repeat GO:0051260 protein homooligomerization GO:0005515 protein binding GO:0016020 membrane KOG1938 Protein with predicted involvement in meiosis (GSG1) Cluster-8309.25559 BF_2 547.15 5.50 4450 91082383 XP_968748.1 4004 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P91660 2692 8.3e-303 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00004//PF09329//PF01695//PF00664//PF00158//PF13304//PF01926//PF01580//PF00931//PF03205//PF02367//PF06414//PF00437//PF00005//PF03193//PF03266//PF01637 ATPase family associated with various cellular activities (AAA)//Primase zinc finger//IstB-like ATP binding protein//ABC transporter transmembrane region//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//FtsK/SpoIIIE family//NB-ARC domain//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Type II/IV secretion system protein//ABC transporter//Protein of unknown function, DUF258//NTPase//Archaeal ATPase GO:0002949//GO:0055085//GO:0006810//GO:0006260//GO:0006777//GO:0006355//GO:0009987 tRNA threonylcarbamoyladenosine modification//transmembrane transport//transport//DNA replication//Mo-molybdopterin cofactor biosynthetic process//regulation of transcription, DNA-templated//cellular process GO:0003677//GO:0043531//GO:0005525//GO:0098519//GO:0005524//GO:0008134//GO:0003924//GO:0016301//GO:0016887//GO:0000166//GO:0042626 DNA binding//ADP binding//GTP binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//transcription factor binding//GTPase activity//kinase activity//ATPase activity//nucleotide binding//ATPase activity, coupled to transmembrane movement of substances GO:0005634//GO:0005667//GO:0016021 nucleus//transcription factor complex//integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.25560 BF_2 49.00 3.91 812 478259687 ENN79531.1 1023 1.3e-108 hypothetical protein YQE_03994, partial [Dendroctonus ponderosae] 755689104 XM_011281044.1 39 7.45326e-09 PREDICTED: Felis catus ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 877 4.4e-93 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF04851//PF01926//PF16647//PF03193//PF00005//PF01695 AAA domain, putative AbiEii toxin, Type IV TA system//Type III restriction enzyme, res subunit//50S ribosome-binding GTPase//Granulocyte colony-stimulating factor//Protein of unknown function, DUF258//ABC transporter//IstB-like ATP binding protein GO:0007165//GO:0006955 signal transduction//immune response GO:0003677//GO:0016787//GO:0005524//GO:0003924//GO:0005125//GO:0016887//GO:0005525 DNA binding//hydrolase activity//ATP binding//GTPase activity//cytokine activity//ATPase activity//GTP binding GO:0005576 extracellular region -- -- Cluster-8309.25563 BF_2 14.00 1.72 628 478257268 ENN77431.1 317 7.1e-27 hypothetical protein YQE_06255, partial [Dendroctonus ponderosae] 744564954 XM_010980230.1 50 4.36804e-15 PREDICTED: Camelus dromedarius ATP-binding cassette, sub-family C (CFTR/MRP), member 4 (ABCC4), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 278 9.7e-24 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter -- -- GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- -- -- Cluster-8309.25564 BF_2 19.00 1.75 742 478258345 ENN78464.1 623 2.8e-62 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 388 2.0e-36 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00437//PF00931//PF00005//PF03193//PF01637//PF01926//PF02367 Type II/IV secretion system protein//NB-ARC domain//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//50S ribosome-binding GTPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0002949//GO:0006810 tRNA threonylcarbamoyladenosine modification//transport GO:0016887//GO:0005524//GO:0005525//GO:0003924//GO:0043531 ATPase activity//ATP binding//GTP binding//GTPase activity//ADP binding -- -- -- -- Cluster-8309.25565 BF_2 61.31 0.73 3803 91082383 XP_968748.1 909 9.7e-95 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 721 2.5e-74 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF13304//PF01926//PF00664 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region GO:0006810//GO:0055085//GO:0009987 transport//transmembrane transport//cellular process GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0000166//GO:0016887 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//nucleotide binding//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.25567 BF_2 16.00 4.76 427 478259687 ENN79531.1 503 1.3e-48 hypothetical protein YQE_03994, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 413 1.5e-39 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF01926//PF03193//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Protein of unknown function, DUF258//ABC transporter -- -- GO:0005525//GO:0005524//GO:0016887//GO:0003924 GTP binding//ATP binding//ATPase activity//GTPase activity -- -- -- -- Cluster-8309.25568 BF_2 30.87 0.36 3908 478258345 ENN78464.1 1662 4.8e-182 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1145 1.8e-123 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF02367//PF00931//PF13304//PF01926//PF00664//PF00004//PF00437 Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006810//GO:0055085//GO:0002949 transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0043531//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.2557 BF_2 2.00 0.66 413 411013040 AFV99179.1 616 9.9e-62 autophagy-related protein 8 [Litopenaeus vannamei]>gi|411013042|gb|AFV99180.1| autophagy-related protein 8 [Penaeus monodon] 332348471 HM149771.1 156 3.32158e-74 Eriocheir sinensis gamma-aminobutyric acid receptor associated protein mRNA, complete cds K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 Q8MK68 580 6.1e-59 Gamma-aminobutyric acid receptor-associated protein OS=Oryctolagus cuniculus GN=GABARAP PE=3 SV=1 PF04110 Ubiquitin-like autophagy protein Apg12 GO:0000045 autophagosome assembly -- -- GO:0005737 cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-8309.25571 BF_2 65.75 0.69 4254 478258345 ENN78464.1 1662 5.3e-182 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1145 1.9e-123 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF02367//PF00931//PF13304//PF01926//PF00664//PF00004//PF00437 Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006810//GO:0055085//GO:0002949 transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0043531//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.25572 BF_2 18.76 0.41 2182 642910256 XP_008198577.1 1549 3.4e-169 PREDICTED: protein capicua homolog isoform X3 [Tribolium castaneum] 642910255 XM_008200355.1 135 8.85027e-62 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X3, mRNA -- -- -- -- Q924A2 321 3.5e-28 Protein capicua homolog OS=Mus musculus GN=Cic PE=1 SV=2 PF02687 FtsX-like permease family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.25574 BF_2 158.23 1.51 4659 642929546 XP_008195880.1 448 3.4e-41 PREDICTED: KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock -- -- -- -- -- -- Cluster-8309.25577 BF_2 162.78 1.62 4485 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.45702e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 1.9e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.25578 BF_2 10.39 4.28 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25579 BF_2 125.31 1.04 5324 835482914 AKM70276.1 219 1.4e-14 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25583 BF_2 318.73 2.90 4886 642911445 XP_008199426.1 2416 2.2e-269 PREDICTED: gamma-1-syntrophin isoform X1 [Tribolium castaneum] 642911446 XM_001815874.2 550 0 PREDICTED: Tribolium castaneum gamma-1-syntrophin (LOC659142), transcript variant X2, mRNA -- -- -- -- Q9NSN8 885 3.1e-93 Gamma-1-syntrophin OS=Homo sapiens GN=SNTG1 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3549 Syntrophins (type gamma) Cluster-8309.25584 BF_2 477.74 5.28 4071 642927132 XP_008195151.1 2005 8.5e-222 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 2.30861e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 1.0e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF07650//PF00013//PF13014//PF03400//PF13184 KH domain//KH domain//KH domain//IS1 transposase//NusA-like KH domain GO:0006313 transposition, DNA-mediated GO:0003723//GO:0003677//GO:0004803 RNA binding//DNA binding//transposase activity -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.25585 BF_2 51.39 4.87 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25589 BF_2 89.08 0.84 4748 546673579 ERL85150.1 2351 7.5e-262 hypothetical protein D910_02572 [Dendroctonus ponderosae] 381143842 JN171289.1 206 6.5995e-101 Bembidion scopulinum voucher DRMaddison:DNA1282 topoisomerase I gene, partial cds K03163 TOP1 DNA topoisomerase I http://www.genome.jp/dbget-bin/www_bget?ko:K03163 P30189 1983 1.5e-220 DNA topoisomerase 1 OS=Drosophila melanogaster GN=Top1 PE=1 SV=1 PF04659//PF01028//PF02919 Archaeal flagella protein//Eukaryotic DNA topoisomerase I, catalytic core//Eukaryotic DNA topoisomerase I, DNA binding fragment GO:0006265//GO:0097588 DNA topological change//archaeal or bacterial-type flagellum-dependent cell motility GO:0003918//GO:0003917//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA topoisomerase type I activity//DNA binding GO:0005694 chromosome KOG0981 DNA topoisomerase I Cluster-8309.25591 BF_2 187.14 4.27 2122 91088121 XP_970262.1 1059 2.2e-112 PREDICTED: ADP-ribose pyrophosphatase, mitochondrial [Tribolium castaneum]>gi|270011859|gb|EFA08307.1| hypothetical protein TcasGA2_TC005943 [Tribolium castaneum] 462283694 APGK01056848.1 68 1.51266e-24 Dendroctonus ponderosae Seq01056858, whole genome shotgun sequence K13988 NUDT9 ADP-ribose pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13988 Q8BVU5 847 3.5e-89 ADP-ribose pyrophosphatase, mitochondrial OS=Mus musculus GN=Nudt9 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4195 Transient receptor potential-related channel 7 Cluster-8309.25595 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25596 BF_2 27.00 0.70 1911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25597 BF_2 74.69 1.03 3324 270009903 EFA06351.1 581 9.2e-57 hypothetical protein TcasGA2_TC009226 [Tribolium castaneum] 759079745 XM_011351395.1 136 3.76724e-62 PREDICTED: Cerapachys biroi protein quiver (LOC105286442), transcript variant X2, mRNA -- -- -- -- B5A5T4 523 2.0e-51 Protein quiver OS=Drosophila melanogaster GN=qvr PE=1 SV=2 PF17064//PF01064 Sleepless protein//Activin types I and II receptor domain GO:0032222//GO:0030431//GO:1903818//GO:0009069//GO:0016310//GO:0007178 regulation of synaptic transmission, cholinergic//sleep//positive regulation of voltage-gated potassium channel activity//serine family amino acid metabolic process//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.25600 BF_2 310.00 6.69 2227 642929895 XP_008196017.1 1798 4.7e-198 PREDICTED: nucleolar protein 9 [Tribolium castaneum]>gi|270010631|gb|EFA07079.1| hypothetical protein TcasGA2_TC010059 [Tribolium castaneum] -- -- -- -- -- K14790 NOP9 nucleolar protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14790 Q86U38 417 2.6e-39 Nucleolar protein 9 OS=Homo sapiens GN=NOP9 PE=1 SV=1 PF07425//PF00806 Pardaxin//Pumilio-family RNA binding repeat -- -- GO:0003723 RNA binding GO:0005576 extracellular region KOG2188 Predicted RNA-binding protein, contains Pumilio domains Cluster-8309.25601 BF_2 111.43 4.03 1443 195376525 XP_002047047.1 303 6.9e-25 GJ12142 [Drosophila virilis]>gi|194154205|gb|EDW69389.1| GJ12142 [Drosophila virilis] -- -- -- -- -- -- -- -- -- Q61830 238 9.7e-19 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- KOG4297 C-type lectin Cluster-8309.25602 BF_2 341.02 8.04 2061 91078172 XP_967060.1 1201 7.3e-129 PREDICTED: sorting nexin-27 [Tribolium castaneum]>gi|270001364|gb|EEZ97811.1| hypothetical protein TcasGA2_TC000177 [Tribolium castaneum] -- -- -- -- -- K17936 SNX27 sorting nexin-27 http://www.genome.jp/dbget-bin/www_bget?ko:K17936 Q96L92 734 4.3e-76 Sorting nexin-27 OS=Homo sapiens GN=SNX27 PE=1 SV=2 PF00788//PF03145//PF03219 Ras association (RalGDS/AF-6) domain//Seven in absentia protein family//TLC ATP/ADP transporter GO:0006810//GO:0007165//GO:0007275//GO:0006511 transport//signal transduction//multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0035091//GO:0005524//GO:0005471 phosphatidylinositol binding//ATP binding//ATP:ADP antiporter activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG3784 Sorting nexin protein SNX27 Cluster-8309.25605 BF_2 142.49 4.14 1727 189239711 XP_966387.2 1319 1.3e-142 PREDICTED: carbohydrate sulfotransferase 11 [Tribolium castaneum]>gi|270009383|gb|EFA05831.1| hypothetical protein TcasGA2_TC008615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P69478 307 1.2e-26 Carbohydrate sulfotransferase 11 OS=Rattus norvegicus GN=Chst11 PE=1 SV=1 PF03567 Sulfotransferase family -- -- GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.25606 BF_2 28.00 2.35 785 751442604 XP_011195955.1 226 3.2e-16 PREDICTED: uncharacterized protein DDB_G0290301 isoform X1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q00690 131 1.4e-06 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25607 BF_2 2.00 17.36 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25610 BF_2 471.00 5.96 3592 91094115 XP_968023.1 4146 0.0e+00 PREDICTED: exportin-2 [Tribolium castaneum]>gi|270010891|gb|EFA07339.1| hypothetical protein TcasGA2_TC015935 [Tribolium castaneum] 746860322 XM_011062696.1 135 1.46538e-61 PREDICTED: Acromyrmex echinatior exportin-2 (LOC105149943), mRNA K18423 CSE1, CAS, XPO2 exportin-2 (importin alpha re-exporter) http://www.genome.jp/dbget-bin/www_bget?ko:K18423 Q8AY73 3056 0.0e+00 Exportin-2 OS=Oreochromis niloticus GN=cse1l PE=2 SV=1 PF00514//PF08506//PF03378//PF03810//PF08064 Armadillo/beta-catenin-like repeat//Cse1//CAS/CSE protein, C-terminus//Importin-beta N-terminal domain//UME (NUC010) domain GO:0006886//GO:0016310//GO:0009069//GO:0015031 intracellular protein transport//phosphorylation//serine family amino acid metabolic process//protein transport GO:0005515//GO:0008536//GO:0008565//GO:0004674 protein binding//Ran GTPase binding//protein transporter activity//protein serine/threonine kinase activity GO:0005643 nuclear pore KOG1992 Nuclear export receptor CSE1/CAS (importin beta superfamily) Cluster-8309.25611 BF_2 259.00 5.52 2251 91094243 XP_968493.1 2462 4.8e-275 PREDICTED: gastrulation defective protein 1 homolog [Tribolium castaneum]>gi|270016277|gb|EFA12723.1| hypothetical protein TcasGA2_TC002358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W1J3 1682 5.5e-186 Gastrulation defective protein 1 homolog OS=Drosophila melanogaster GN=CG5543 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0772 Uncharacterized conserved protein, contains WD40 repeat Cluster-8309.25614 BF_2 1538.00 28.22 2567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02123 Viral RNA-directed RNA-polymerase GO:0006351//GO:0006144 transcription, DNA-templated//purine nucleobase metabolic process GO:0003968//GO:0003723 RNA-directed RNA polymerase activity//RNA binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.25615 BF_2 7.00 1.27 518 56199560 AAV84269.1 248 5.9e-19 ribosomal protein P2-like [Culicoides sonorensis] 242002645 XM_002435921.1 51 9.89575e-16 Ixodes scapularis hypothetical protein, mRNA K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P05389 206 1.8e-15 60S acidic ribosomal protein P2 OS=Drosophila melanogaster GN=RpLP2 PE=1 SV=1 PF16320//PF05456 Ribosomal protein L7/L12 dimerisation domain//Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) GO:0042254//GO:0006412//GO:0045947 ribosome biogenesis//translation//negative regulation of translational initiation GO:0008190//GO:0003735 eukaryotic initiation factor 4E binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3449 60S acidic ribosomal protein P2 Cluster-8309.25617 BF_2 34.12 0.42 3704 270001943 EEZ98390.1 619 4.0e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 1.39837e-116 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 1.7e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.25618 BF_2 42.07 0.39 4825 642912765 XP_008201238.1 1139 2.6e-121 PREDICTED: transcription factor deformed isoform X1 [Tribolium castaneum] 676432024 XM_009048192.1 82 5.72494e-32 Lottia gigantea hypothetical protein partial mRNA K09304 HOX_4 homeobox protein HoxA/B/C/D4 http://www.genome.jp/dbget-bin/www_bget?ko:K09304 P07548 480 2.8e-46 Homeotic protein deformed OS=Drosophila melanogaster GN=Dfd PE=1 SV=2 PF07244//PF00046 Surface antigen variable number repeat//Homeobox domain -- -- GO:0003677 DNA binding GO:0019867 outer membrane -- -- Cluster-8309.25621 BF_2 36.93 2.55 892 642936262 XP_008198373.1 1063 3.2e-113 PREDICTED: bifunctional protein NCOAT isoform X1 [Tribolium castaneum]>gi|270014068|gb|EFA10516.1| hypothetical protein TcasGA2_TC012768 [Tribolium castaneum] 830022072 XM_012723671.1 44 1.36574e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 694 8.0e-72 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3698 Hyaluronoglucosaminidase Cluster-8309.25622 BF_2 388.86 1.53 10924 571541195 XP_006569521.1 5346 0.0e+00 PREDICTED: small subunit processome component 20 homolog, partial [Apis mellifera] -- -- -- -- -- K14772 UTP20 U3 small nucleolar RNA-associated protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K14772 Q5XG71 1869 5.5e-207 Small subunit processome component 20 homolog OS=Mus musculus GN=Utp20 PE=2 SV=2 PF02152//PF02985//PF01701//PF07647 Dihydroneopterin aldolase//HEAT repeat//Photosystem I reaction centre subunit IX / PsaJ//SAM domain (Sterile alpha motif) GO:0006760//GO:0046656//GO:0015979 folic acid-containing compound metabolic process//folic acid biosynthetic process//photosynthesis GO:0004150//GO:0005515 dihydroneopterin aldolase activity//protein binding GO:0009522 photosystem I KOG1823 DRIM (Down-regulated in metastasis)-like proteins Cluster-8309.25625 BF_2 121.32 0.84 6341 642920112 XP_008192210.1 1223 6.3e-131 PREDICTED: E3 ubiquitin-protein ligase SH3RF1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.3e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF13912//PF02892//PF09360//PF16622//PF14604//PF00018//PF13465//PF13639//PF14634//PF17123//PF00097//PF00096 C2H2-type zinc finger//BED zinc finger//Iron-binding zinc finger CDGSH type//zinc-finger C2H2-type//Variant SH3 domain//SH3 domain//Zinc-finger double domain//Ring finger domain//zinc-RING finger domain//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type -- -- GO:0005515//GO:0046872//GO:0003677//GO:0008270//GO:0051537 protein binding//metal ion binding//DNA binding//zinc ion binding//2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.25627 BF_2 274.32 9.52 1493 642929611 XP_975458.3 1430 1.5e-155 PREDICTED: lanC-like protein 3 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y0Y7 888 4.3e-94 LanC-like protein 3 homolog OS=Drosophila melanogaster GN=CG2061 PE=2 SV=1 PF04911//PF06662 ATP synthase j chain//D-glucuronyl C5-epimerase C-terminus GO:0015992//GO:0006024//GO:0015986 proton transport//glycosaminoglycan biosynthetic process//ATP synthesis coupled proton transport GO:0016857//GO:0015078 racemase and epimerase activity, acting on carbohydrates and derivatives//hydrogen ion transmembrane transporter activity GO:0045263//GO:0016021 proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane KOG2787 Lanthionine synthetase C-like protein 1 Cluster-8309.25629 BF_2 244.89 3.58 3151 -- -- -- -- -- 642922625 XM_008195033.1 61 1.75719e-20 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF08001 CMV US GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0044386 integral to host endoplasmic reticulum membrane -- -- Cluster-8309.25632 BF_2 3.00 0.95 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25634 BF_2 376.56 2.94 5652 642928644 XP_008199718.1 1825 8.8e-201 PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZF3 1247 3.8e-135 Oxysterol-binding protein-related protein 6 OS=Homo sapiens GN=OSBPL6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25636 BF_2 419.00 44.39 682 546682766 ERL92655.1 361 6.1e-32 hypothetical protein D910_09968 [Dendroctonus ponderosae] -- -- -- -- -- K00020 E1.1.1.31, mmsB 3-hydroxyisobutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00020 Q9L7S0 244 9.3e-20 3-sulfolactaldehyde reductase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=yihU PE=3 SV=1 PF03720//PF03446//PF02826//PF01210//PF02737 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0046168//GO:0006633//GO:0006098//GO:0018874//GO:0006631//GO:0006552//GO:0006574//GO:0006550//GO:0006568//GO:0019521//GO:0006554//GO:0055114 glycerol-3-phosphate catabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//fatty acid metabolic process//leucine catabolic process//valine catabolic process//isoleucine catabolic process//tryptophan metabolic process//D-gluconate metabolic process//lysine catabolic process//oxidation-reduction process GO:0016491//GO:0051287//GO:0016616//GO:0003857//GO:0004616 oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG0409 Predicted dehydrogenase Cluster-8309.25638 BF_2 103.43 1.97 2481 332373480 AEE61881.1 672 1.9e-67 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00798 MMAB, pduO cob(I)alamin adenosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00798 Q96EY8 328 6.1e-29 Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial OS=Homo sapiens GN=MMAB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25641 BF_2 26.01 0.71 1830 642931814 XP_008196744.1 320 9.3e-27 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 276 4.8e-23 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.25645 BF_2 3.00 2.64 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25647 BF_2 114.55 1.52 3439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651//PF04573 BTB/POZ domain//Signal peptidase subunit GO:0006465 signal peptide processing GO:0005515//GO:0008233 protein binding//peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.2565 BF_2 80.34 1.02 3591 91090914 XP_974006.1 2359 6.7e-263 PREDICTED: NCK-interacting protein with SH3 domain [Tribolium castaneum]>gi|270013220|gb|EFA09668.1| hypothetical protein TcasGA2_TC011794 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESJ4 877 1.9e-92 NCK-interacting protein with SH3 domain OS=Mus musculus GN=Nckipsd PE=2 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover Cluster-8309.25650 BF_2 45.02 0.59 3500 642912878 XP_971323.2 657 1.5e-65 PREDICTED: EP300-interacting inhibitor of differentiation 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXX6 190 8.7e-13 Non-structural maintenance of chromosomes element 4 homolog A OS=Homo sapiens GN=NSMCE4A PE=1 SV=2 PF00790//PF01405 VHS domain//Photosystem II reaction centre T protein GO:0006886//GO:0015979 intracellular protein transport//photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane KOG2866 Uncharacterized conserved protein Cluster-8309.25651 BF_2 305.57 3.16 4336 642919915 XP_008192123.1 1850 8.5e-204 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9K8 222 2.1e-16 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0507 CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain Cluster-8309.25653 BF_2 19.00 4.10 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25654 BF_2 93.00 1.76 2502 478260545 ENN80248.1 1811 1.6e-199 hypothetical protein YQE_03243, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AW46 520 3.4e-51 Carboxylesterase 5A OS=Mus musculus GN=Ces5a PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.25656 BF_2 114.64 0.96 5306 546678750 ERL89302.1 1238 9.6e-133 hypothetical protein D910_06674 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05656//PF12106 Protein of unknown function (DUF805)//Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.25657 BF_2 489.83 11.45 2077 546676934 ERL87858.1 1197 2.1e-128 hypothetical protein D910_05246 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26422 380 4.8e-35 Limulus clotting factor C OS=Carcinoscorpius rotundicauda PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25658 BF_2 62.28 0.87 3289 478253154 ENN73525.1 1577 2.9e-172 hypothetical protein YQE_09776, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 854 8.3e-90 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF06756//PF01370//PF01073 Male sterility protein//Chorion protein S19 C-terminal//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0008210//GO:0007275 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//estrogen metabolic process//multicellular organismal development GO:0080019//GO:0016616//GO:0003824//GO:0050662//GO:0003854 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity GO:0042600 chorion KOG1221 Acyl-CoA reductase Cluster-8309.25659 BF_2 26.11 1.06 1315 817202705 XP_012277149.1 284 1.0e-22 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Orussus abietinus] -- -- -- -- -- K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 219 1.4e-16 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.25660 BF_2 15.00 4.02 443 642920118 XP_008192213.1 262 1.2e-20 PREDICTED: microtubule-associated protein futsch isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25661 BF_2 5.00 0.80 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25663 BF_2 106.61 3.29 1643 642937136 XP_008198708.1 276 1.1e-21 PREDICTED: arginine/serine-rich protein PNISR [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04441 Poxvirus early transcription factor (VETF), large subunit GO:0045893 positive regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.25664 BF_2 26.66 0.80 1673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25667 BF_2 152.66 1.78 3869 642922614 XP_008193249.1 1384 8.2e-150 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25668 BF_2 280.00 8.96 1595 642913239 XP_008201452.1 1470 3.6e-160 PREDICTED: WD repeat-containing protein 61 [Tribolium castaneum]>gi|270001971|gb|EEZ98418.1| hypothetical protein TcasGA2_TC000886 [Tribolium castaneum] 780072616 XM_791333.4 58 4.09556e-19 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 61-like (LOC591782), mRNA K12602 WDR61, REC14, SKI8 WD repeat-containing protein 61 http://www.genome.jp/dbget-bin/www_bget?ko:K12602 Q6P5M2 1052 4.4e-113 WD repeat-containing protein 61 OS=Danio rerio GN=wdr61 PE=2 SV=1 PF02897//PF04053//PF00400 Prolyl oligopeptidase, N-terminal beta-propeller domain//Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0070008//GO:0004252//GO:0005515//GO:0005198 serine-type exopeptidase activity//serine-type endopeptidase activity//protein binding//structural molecule activity GO:0030117 membrane coat KOG4155 FOG: WD40 repeat Cluster-8309.25669 BF_2 4.00 2.89 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2567 BF_2 4.00 0.64 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25670 BF_2 129.86 2.57 2405 91076548 XP_966358.1 499 2.1e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.6e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF00010//PF05093 Helix-loop-helix DNA-binding domain//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226 iron-sulfur cluster assembly GO:0046983//GO:0051536 protein dimerization activity//iron-sulfur cluster binding GO:0005737 cytoplasm KOG4020 Protein DRE2, required for cell viability Cluster-8309.25674 BF_2 15.13 0.34 2172 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.25676 BF_2 168.89 1.32 5644 642927663 XP_008195354.1 1282 8.1e-138 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 Q9Y2K5 394 3.1e-36 R3H domain-containing protein 2 OS=Homo sapiens GN=R3HDM2 PE=1 SV=3 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.25678 BF_2 118.00 6.02 1107 766938885 XP_011501969.1 577 8.9e-57 PREDICTED: troponin T, skeletal muscle isoform X1 [Ceratosolen solmsi marchali] -- -- -- -- -- K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 Q9XZ71 491 3.4e-48 Troponin T OS=Periplaneta americana GN=TNT PE=2 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3634 Troponin Cluster-8309.25679 BF_2 13.00 0.42 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25680 BF_2 2.02 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25685 BF_2 179.59 0.97 8050 546671878 ERL83997.1 3669 0.0e+00 hypothetical protein D910_01313 [Dendroctonus ponderosae]>gi|546679661|gb|ERL90088.1| hypothetical protein D910_07442 [Dendroctonus ponderosae] -- -- -- -- -- K17935 SNX29 sorting nexin-29 http://www.genome.jp/dbget-bin/www_bget?ko:K17935 Q9VKB9 1409 8.9e-154 Rab3 GTPase-activating protein regulatory subunit OS=Drosophila melanogaster GN=rab3-GAP PE=1 SV=2 PF00787//PF04977//PF00957 PX domain//Septum formation initiator//Synaptobrevin GO:0007049//GO:0016192 cell cycle//vesicle-mediated transport GO:0035091 phosphatidylinositol binding GO:0016021 integral component of membrane KOG2727 Rab3 GTPase-activating protein, non-catalytic subunit Cluster-8309.25688 BF_2 165.84 2.13 3547 91094433 XP_969675.1 2027 2.1e-224 PREDICTED: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X2 [Tribolium castaneum] 752875257 XM_011256672.1 68 2.54398e-24 PREDICTED: Camponotus floridanus alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC105250520), transcript variant X5, mRNA K00736 MGAT2 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00736 Q921V5 959 6.0e-102 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat2 PE=2 SV=1 PF00437//PF06414//PF02367//PF01121//PF05060 Type II/IV secretion system protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dephospho-CoA kinase//N-acetylglucosaminyltransferase II (MGAT2) GO:0015937//GO:0002949//GO:0006810//GO:0009312//GO:0015940 coenzyme A biosynthetic process//tRNA threonylcarbamoyladenosine modification//transport//oligosaccharide biosynthetic process//pantothenate biosynthetic process GO:0004140//GO:0016301//GO:0008455//GO:0005524 dephospho-CoA kinase activity//kinase activity//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//ATP binding GO:0005795//GO:0016021 Golgi stack//integral component of membrane KOG2791 N-acetylglucosaminyltransferase Cluster-8309.25689 BF_2 17.31 0.32 2524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25691 BF_2 875.99 10.95 3634 642930006 XP_008196062.1 305 1.0e-24 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 1.1e-18 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25692 BF_2 14.00 7.00 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25693 BF_2 5.81 3.75 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00020//PF06784 Zinc-finger associated domain (zf-AD)//TNFR/NGFR cysteine-rich region//Uncharacterised protein family (UPF0240) GO:0032981 mitochondrial respiratory chain complex I assembly GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25696 BF_2 13.00 8.62 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25697 BF_2 3.00 0.89 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25698 BF_2 17.38 0.32 2530 642924692 XP_008194400.1 996 5.3e-105 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 265 1.3e-21 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.25699 BF_2 9.00 0.47 1089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25701 BF_2 10.00 0.82 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25703 BF_2 219.44 1.10 8639 642913355 XP_008195386.1 6061 0.0e+00 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K11757 PBRM1, PB1 protein polybromo-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11757 Q86U86 1886 4.7e-209 Protein polybromo-1 OS=Homo sapiens GN=PBRM1 PE=1 SV=1 PF07728//PF10505//PF07726//PF01580//PF01426//PF00493//PF00439 AAA domain (dynein-related subfamily)//NMDA receptor-regulated gene protein 2 C-terminus//ATPase family associated with various cellular activities (AAA)//FtsK/SpoIIIE family//BAH domain//MCM2/3/5 family//Bromodomain GO:0006260 DNA replication GO:0005515//GO:0003677//GO:0005524//GO:0003682//GO:0016887//GO:0000166 protein binding//DNA binding//ATP binding//chromatin binding//ATPase activity//nucleotide binding GO:0000785//GO:0008023 chromatin//transcription elongation factor complex KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.25706 BF_2 34.80 0.82 2052 642915551 XP_008190663.1 1004 5.1e-106 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 70 1.13014e-25 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 353 6.4e-32 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.25708 BF_2 30.05 2.31 831 642915056 XP_008190391.1 278 3.1e-22 PREDICTED: uncharacterized protein LOC103312182 [Tribolium castaneum]>gi|270001357|gb|EEZ97804.1| hypothetical protein TcasGA2_TC000168 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25710 BF_2 15.23 0.93 975 499140776 AGL76355.1 265 1.2e-20 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 241 3.0e-19 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05529//PF05531//PF03998 B-cell receptor-associated protein 31-like//Nucleopolyhedrovirus P10 protein//Utp11 protein GO:0006364//GO:0006886 rRNA processing//intracellular protein transport -- -- GO:0019028//GO:0016021//GO:0005783//GO:0032040 viral capsid//integral component of membrane//endoplasmic reticulum//small-subunit processome -- -- Cluster-8309.25711 BF_2 16.69 0.45 1824 642917000 XP_008199589.1 600 3.2e-59 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 238 1.2e-18 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.25712 BF_2 305.60 2.04 6561 642921466 XP_008192880.1 4105 0.0e+00 PREDICTED: transient receptor potential-gamma protein [Tribolium castaneum] 194884299 XM_001976197.1 386 0 Drosophila erecta GG20120 (Dere\GG20120), mRNA K05328 TRPCN transient receptor potential cation channel subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05328 Q9VJJ7 3423 0.0e+00 Transient receptor potential-gamma protein OS=Drosophila melanogaster GN=Trpgamma PE=1 SV=2 PF04692//PF09726//PF13606//PF00520 Platelet-derived growth factor, N terminal region//Transmembrane protein//Ankyrin repeat//Ion transport protein GO:0006811//GO:0008283//GO:0055085//GO:0040007//GO:0007165 ion transport//cell proliferation//transmembrane transport//growth//signal transduction GO:0005216//GO:0005515//GO:0008083 ion channel activity//protein binding//growth factor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.25715 BF_2 71.57 3.99 1038 642919467 XP_008191881.1 746 2.1e-76 PREDICTED: polyprenol reductase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 473 3.9e-46 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1640 Predicted steroid reductase Cluster-8309.25716 BF_2 396.49 5.57 3267 189238741 XP_972079.2 3168 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927110|ref|XP_008195141.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927112|ref|XP_008195142.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927115|ref|XP_008195143.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum] 699256288 XM_009863644.1 39 3.09336e-08 PREDICTED: Ciona intestinalis ubiquitin carboxyl-terminal hydrolase 20-like (LOC100184024), mRNA K11848 USP20_33 ubiquitin carboxyl-terminal hydrolase 20/33 http://www.genome.jp/dbget-bin/www_bget?ko:K11848 A0JM59 1233 9.3e-134 Ubiquitin carboxyl-terminal hydrolase 20 OS=Xenopus tropicalis GN=usp20 PE=2 SV=1 PF00443//PF06337//PF17001//PF02148 Ubiquitin carboxyl-terminal hydrolase//DUSP domain//Type III secretion basal body protein I, YscI, HrpB, PscI//Zn-finger in ubiquitin-hydrolases and other protein GO:0006508//GO:0016579//GO:0009306 proteolysis//protein deubiquitination//protein secretion GO:0004843//GO:0008270//GO:0036459 ubiquitin-specific protease activity//zinc ion binding//ubiquitinyl hydrolase activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.25719 BF_2 271.77 3.77 3306 478259275 ENN79177.1 371 2.1e-32 hypothetical protein YQE_04361, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25720 BF_2 412.35 8.99 2206 189238996 XP_974023.2 1856 8.7e-205 PREDICTED: E3 SUMO-protein ligase PIAS2 [Tribolium castaneum]>gi|270010268|gb|EFA06716.1| hypothetical protein TcasGA2_TC009647 [Tribolium castaneum] -- -- -- -- -- K04706 PIAS1 E3 SUMO-protein ligase PIAS1 http://www.genome.jp/dbget-bin/www_bget?ko:K04706 O70260 1111 8.8e-120 E3 SUMO-protein ligase PIAS3 OS=Rattus norvegicus GN=Pias3 PE=1 SV=2 PF13639//PF11789//PF00097//PF02891 Ring finger domain//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger -- -- GO:0008270//GO:0005488//GO:0005515//GO:0046872 zinc ion binding//binding//protein binding//metal ion binding -- -- KOG2169 Zn-finger transcription factor Cluster-8309.25721 BF_2 45.92 1.22 1860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25722 BF_2 74.00 5.95 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25723 BF_2 8.00 1.07 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25725 BF_2 61.00 8.45 589 642912278 XP_967486.2 173 3.3e-10 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25727 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12833//PF05392 Helix-turn-helix domain//Cytochrome C oxidase chain VIIB GO:0006123//GO:0015992//GO:0006355 mitochondrial electron transport, cytochrome c to oxygen//proton transport//regulation of transcription, DNA-templated GO:0004129//GO:0003700//GO:0043565 cytochrome-c oxidase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0045277//GO:0005746//GO:0005667 respiratory chain complex IV//mitochondrial respiratory chain//transcription factor complex -- -- Cluster-8309.25728 BF_2 22.17 0.48 2204 642912272 XP_008200632.1 843 2.5e-87 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 298 1.6e-25 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF05392//PF00089 Cytochrome C oxidase chain VIIB//Trypsin GO:0015992//GO:0006508//GO:0006123 proton transport//proteolysis//mitochondrial electron transport, cytochrome c to oxygen GO:0004252//GO:0004129 serine-type endopeptidase activity//cytochrome-c oxidase activity GO:0005746//GO:0045277 mitochondrial respiratory chain//respiratory chain complex IV -- -- Cluster-8309.25729 BF_2 4.00 0.63 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25730 BF_2 19.03 0.40 2272 642912272 XP_008200632.1 761 8.4e-78 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 288 2.4e-24 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF05392 Trypsin//Cytochrome C oxidase chain VIIB GO:0006508//GO:0006123//GO:0015992 proteolysis//mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004252//GO:0004129 serine-type endopeptidase activity//cytochrome-c oxidase activity GO:0045277//GO:0005746 respiratory chain complex IV//mitochondrial respiratory chain -- -- Cluster-8309.25731 BF_2 46.14 1.73 1402 642912272 XP_008200632.1 540 2.2e-52 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66TN7 173 3.3e-11 Ovochymase-2 OS=Rhinella arenarum GN=OVCH2 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25732 BF_2 254.63 1.54 7200 642927083 XP_008195130.1 5762 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927082 XM_008196908.1 520 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X1, mRNA -- -- -- -- Q9ULI1 411 4.2e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF07728//PF00004//PF01637//PF03193//PF00005//PF00400//PF00931//PF00910 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//WD domain, G-beta repeat//NB-ARC domain//RNA helicase -- -- GO:0043531//GO:0005515//GO:0003924//GO:0005524//GO:0003723//GO:0003724//GO:0005525//GO:0016887 ADP binding//protein binding//GTPase activity//ATP binding//RNA binding//RNA helicase activity//GTP binding//ATPase activity -- -- -- -- Cluster-8309.25733 BF_2 155.00 5.92 1383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25737 BF_2 397.03 2.45 7067 91085635 XP_970327.1 2265 1.0e-251 PREDICTED: uncharacterized protein LOC658883 [Tribolium castaneum]>gi|270010087|gb|EFA06535.1| hypothetical protein TcasGA2_TC009439 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00705 Proliferating cell nuclear antigen, N-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding -- -- -- -- Cluster-8309.25741 BF_2 306.00 21.67 878 642933127 XP_008197269.1 697 8.6e-71 PREDICTED: charged multivesicular body protein 2b [Tribolium castaneum]>gi|270011429|gb|EFA07877.1| hypothetical protein TcasGA2_TC005451 [Tribolium castaneum] -- -- -- -- -- K12192 CHMP2B charged multivesicular body protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K12192 Q66IV6 388 2.4e-36 Charged multivesicular body protein 2b-B OS=Xenopus laevis GN=chmp2b-b PE=2 SV=1 PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.25742 BF_2 299.34 1.93 6771 820864069 XP_012348652.1 1708 3.9e-187 PREDICTED: LOW QUALITY PROTEIN: mucin-5AC [Apis florea] -- -- -- -- -- -- -- -- -- Q6W2J9 449 1.6e-42 BCL-6 corepressor OS=Homo sapiens GN=BCOR PE=1 SV=1 PF13606//PF00023//PF01361 Ankyrin repeat//Ankyrin repeat//Tautomerase enzyme GO:0006725 cellular aromatic compound metabolic process GO:0016853//GO:0005515 isomerase activity//protein binding -- -- -- -- Cluster-8309.25744 BF_2 501.26 10.73 2242 642914102 XP_008201543.1 1509 1.5e-164 PREDICTED: ras-interacting protein RIP3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379//PF06371//PF00916 Insect cuticle protein//Diaphanous GTPase-binding Domain//Sulfate permease family GO:0008272//GO:0030036 sulfate transport//actin cytoskeleton organization GO:0015116//GO:0042302//GO:0017048//GO:0003779 sulfate transmembrane transporter activity//structural constituent of cuticle//Rho GTPase binding//actin binding GO:0016021 integral component of membrane -- -- Cluster-8309.25747 BF_2 27.87 0.53 2486 642919661 XP_008192012.1 202 6.1e-13 PREDICTED: kinesin light chain isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25748 BF_2 80.09 2.49 1634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01446 Replication protein GO:0006260 DNA replication GO:0003677 DNA binding GO:0005727 extrachromosomal circular DNA -- -- Cluster-8309.25749 BF_2 106.76 3.33 1629 91076220 XP_972698.1 1772 3.5e-195 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 206 2.23321e-101 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q99N01 455 7.6e-44 Solute carrier organic anion transporter family member 4A1 OS=Rattus norvegicus GN=Slco4a1 PE=2 SV=1 PF07690//PF03137 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3626 Organic anion transporter Cluster-8309.25753 BF_2 8.00 0.61 839 478250393 ENN70888.1 799 1.2e-82 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] 532094238 XM_005332740.1 34 4.64138e-06 PREDICTED: Spermophilus tridecemlineatus fatty acid synthase (Fasn), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 682 1.9e-70 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.25754 BF_2 6.00 0.56 738 546672885 ERL84608.1 714 7.7e-73 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 617 5.6e-63 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107//PF00106 Zinc-binding dehydrogenase//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.25756 BF_2 145.99 4.49 1646 332375332 AEE62807.1 1414 1.2e-153 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 464 6.9e-45 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00098//PF00852 Zinc knuckle//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417//GO:0003676//GO:0008270 fucosyltransferase activity//nucleic acid binding//zinc ion binding GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.25757 BF_2 1364.98 64.46 1173 459485591 AGG68958.1 1339 4.1e-145 prohibitin-1 [Leptinotarsa decemlineata] 459485590 JX275964.1 294 1.92156e-150 Leptinotarsa decemlineata prohibitin-1 mRNA, complete cds K17080 PHB1 prohibitin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17080 P24156 1162 5.7e-126 Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc PE=2 SV=2 PF03242 Late embryogenesis abundant protein GO:0006950 response to stress -- -- -- -- KOG3083 Prohibitin Cluster-8309.25758 BF_2 11.00 31.72 271 91094083 XP_970629.1 248 3.1e-19 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270016176|gb|EFA12624.1| hypothetical protein TcasGA2_TC010257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 200 4.6e-15 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF02882//PF00106//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0055114//GO:0009396//GO:0046487//GO:0008152 oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process GO:0000166//GO:0016491//GO:0004488//GO:0003824//GO:0050662 nucleotide binding//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.25759 BF_2 2.00 10.96 250 642925814 XP_970128.3 322 7.4e-28 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 215 7.8e-17 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.25760 BF_2 62.11 0.91 3154 91094507 XP_971663.1 1499 3.1e-163 PREDICTED: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270000751|gb|EEZ97198.1| hypothetical protein TcasGA2_TC004386 [Tribolium castaneum] -- -- -- -- -- K00166 BCKDHA, bkdA1 2-oxoisovalerate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00166 Q8HXY4 1341 2.7e-146 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Macaca fascicularis GN=BCKDHA PE=2 SV=1 PF13292//PF01553//PF02775//PF00676 1-deoxy-D-xylulose-5-phosphate synthase//Acyltransferase//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Dehydrogenase E1 component GO:0008152//GO:0016114//GO:0006694 metabolic process//terpenoid biosynthetic process//steroid biosynthetic process GO:0016624//GO:0003824//GO:0016746//GO:0030976//GO:0008661 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity//transferase activity, transferring acyl groups//thiamine pyrophosphate binding//1-deoxy-D-xylulose-5-phosphate synthase activity -- -- KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.25763 BF_2 301.31 3.04 4431 642923468 XP_008193757.1 632 1.5e-62 PREDICTED: glia maturation factor beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49858 447 1.7e-42 Protein cornichon OS=Drosophila melanogaster GN=cni PE=1 SV=1 PF03311//PF00241 Cornichon protein//Cofilin/tropomyosin-type actin-binding protein GO:0035556 intracellular signal transduction GO:0003779 actin binding GO:0016020//GO:0005622 membrane//intracellular KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.25765 BF_2 171.51 1.59 4796 270004497 EFA00945.1 1275 4.5e-137 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q2KHZ2 863 1.1e-90 HBS1-like protein OS=Bos taurus GN=HBS1L PE=2 SV=1 PF08477//PF01926//PF05773 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//RWD domain GO:0007264 small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.25768 BF_2 55.00 0.64 3859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25769 BF_2 21.69 0.62 1739 478258496 ENN78571.1 1784 1.5e-196 hypothetical protein YQE_04939, partial [Dendroctonus ponderosae]>gi|546677392|gb|ERL88238.1| hypothetical protein D910_05626 [Dendroctonus ponderosae] 768436038 XM_011561181.1 53 2.69242e-16 PREDICTED: Plutella xylostella PRKCA-binding protein-like (LOC105389970), mRNA -- -- -- -- Q5REH1 1186 1.4e-128 PRKCA-binding protein OS=Pongo abelii GN=PICK1 PE=2 SV=1 PF00595//PF06456//PF13180 PDZ domain (Also known as DHR or GLGF)//Arfaptin-like domain//PDZ domain -- -- GO:0019904//GO:0005515 protein domain specific binding//protein binding -- -- KOG3651 Protein kinase C, alpha binding protein Cluster-8309.25770 BF_2 163.32 1.33 5434 478255001 ENN75234.1 3133 0.0e+00 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1964 2.7e-218 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00437//PF13304//PF01926//PF00664//PF01580//PF06414//PF01637//PF03193//PF00005 Type II/IV secretion system protein//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//FtsK/SpoIIIE family//Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0016301//GO:0000166//GO:0005525//GO:0042626//GO:0003677//GO:0005524//GO:0003924 ATPase activity//kinase activity//nucleotide binding//GTP binding//ATPase activity, coupled to transmembrane movement of substances//DNA binding//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.25771 BF_2 288.00 6.30 2200 642936940 XP_008198620.1 198 1.6e-12 PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum]>gi|642936942|ref|XP_008198621.1| PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25773 BF_2 15.00 0.74 1140 546677187 ERL88072.1 235 4.2e-17 hypothetical protein D910_05461, partial [Dendroctonus ponderosae] 642936943 XM_008200400.1 88 6.11184e-36 PREDICTED: Tribolium castaneum angiomotin-like protein 1 (LOC654850), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25774 BF_2 744.62 11.01 3116 642936944 XP_008198622.1 2562 1.7e-286 PREDICTED: angiomotin-like 2a isoform X2 [Tribolium castaneum] -- -- -- -- -- K16819 AMOT angiomotin http://www.genome.jp/dbget-bin/www_bget?ko:K16819 Q4VCS5 521 3.2e-51 Angiomotin OS=Homo sapiens GN=AMOT PE=1 SV=1 PF05531 Nucleopolyhedrovirus P10 protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.25775 BF_2 14.58 0.43 1694 478253593 ENN73901.1 295 6.8e-24 hypothetical protein YQE_09500, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25776 BF_2 88.79 1.02 3918 642936946 XP_008198623.1 2270 1.5e-252 PREDICTED: angiomotin-like protein 1 isoform X3 [Tribolium castaneum] 642936945 XM_008200401.1 387 0 PREDICTED: Tribolium castaneum angiomotin-like protein 1 (LOC654850), transcript variant X4, mRNA K16819 AMOT angiomotin http://www.genome.jp/dbget-bin/www_bget?ko:K16819 Q4VCS5 521 4.0e-51 Angiomotin OS=Homo sapiens GN=AMOT PE=1 SV=1 PF05531 Nucleopolyhedrovirus P10 protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.25778 BF_2 45.70 1.65 1443 642919030 XP_008191704.1 876 2.5e-91 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 194893660 XM_001977880.1 36 6.2737e-07 Drosophila erecta GG19306 (Dere\GG19306), mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 -- -- -- -- PF10458//PF12920 Valyl tRNA synthetase tRNA binding arm//TcdA/TcdB pore forming domain GO:0009099//GO:0009098//GO:0006438//GO:0009405//GO:0009097 valine biosynthetic process//leucine biosynthetic process//valyl-tRNA aminoacylation//pathogenesis//isoleucine biosynthetic process GO:0000166//GO:0004832//GO:0005524 nucleotide binding//valine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.25782 BF_2 13.02 1.07 794 91093363 XP_969584.1 622 3.9e-62 PREDICTED: proliferation-associated protein 2G4 [Tribolium castaneum]>gi|270015297|gb|EFA11745.1| hypothetical protein TcasGA2_TC004235 [Tribolium castaneum] 112420264 BT027081.1 59 5.54934e-20 Gasterosteus aculeatus clone CFW165-G07 mRNA sequence -- -- -- -- P50580 412 3.6e-39 Proliferation-associated protein 2G4 OS=Mus musculus GN=Pa2g4 PE=1 SV=3 PF01781 Ribosomal L38e protein family GO:0042254//GO:0006412//GO:0009987 ribosome biogenesis//translation//cellular process GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2776 Metallopeptidase Cluster-8309.25784 BF_2 74.29 0.63 5198 642936907 XP_008194437.1 1988 1.0e-219 PREDICTED: fasciclin-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 1347 8.9e-147 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 PF15427//PF04433 S100P-binding protein//SWIRM domain -- -- GO:0048306//GO:0005515 calcium-dependent protein binding//protein binding -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.25791 BF_2 29.67 0.72 2012 642935785 XP_008198173.1 306 4.3e-25 PREDICTED: uncharacterized protein LOC655305 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.25792 BF_2 5.00 3.32 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25795 BF_2 467.21 7.97 2738 646702398 KDR11610.1 798 5.2e-82 GTP-binding protein Rheb-like protein [Zootermopsis nevadensis] 556946329 XM_005986343.1 39 2.5869e-08 PREDICTED: Latimeria chalumnae GTP-binding protein Rheb-like (LOC102353752), mRNA K07208 RHEB Ras homolog enriched in brain http://www.genome.jp/dbget-bin/www_bget?ko:K07208 Q9VND8 698 8.4e-72 GTP-binding protein Rheb homolog OS=Drosophila melanogaster GN=Rheb PE=2 SV=1 PF01926//PF01637//PF08477//PF03193//PF00071//PF00025 50S ribosome-binding GTPase//Archaeal ATPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.25798 BF_2 911.68 11.52 3597 332374232 AEE62257.1 402 5.7e-36 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VBV3 253 4.4e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25799 BF_2 318.00 9.70 1658 478249792 ENN70299.1 375 3.5e-33 hypothetical protein YQE_12810, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08918 PhoQ Sensor GO:0018106//GO:0016310//GO:0000160 peptidyl-histidine phosphorylation//phosphorylation//phosphorelay signal transduction system GO:0046872//GO:0004673//GO:0005524 metal ion binding//protein histidine kinase activity//ATP binding GO:0016020//GO:0009365 membrane//protein histidine kinase complex -- -- Cluster-8309.25800 BF_2 30.00 1.10 1429 758375335 AJO70008.1 1904 1.5e-210 sarco/endoplasmic reticulum calcium-ATPase isoform 3 [Cherax destructor] 768415454 XM_011549976.1 557 0 PREDICTED: Plutella xylostella calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC105380420), transcript variant X5, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 1714 6.8e-190 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.25801 BF_2 69.74 1.01 3183 546684480 ERL94119.1 710 9.7e-72 hypothetical protein D910_11401 [Dendroctonus ponderosae] -- -- -- -- -- K18407 TDRD5 tudor domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18407 Q4R3G4 152 2.0e-08 RING finger protein 17 OS=Macaca fascicularis GN=RNF17 PE=2 SV=2 PF15151 Response gene to complement 32 protein family GO:0051726 regulation of cell cycle -- -- -- -- -- -- Cluster-8309.25802 BF_2 105.33 2.01 2480 642916810 XP_967695.2 1570 1.4e-171 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 1086 7.8e-117 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00737//PF00307 Photosystem II 10 kDa phosphoprotein//Calponin homology (CH) domain GO:0050821//GO:0015979 protein stabilization//photosynthesis GO:0005515//GO:0042301 protein binding//phosphate ion binding GO:0009523//GO:0016020 photosystem II//membrane KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.25806 BF_2 277.58 8.88 1595 642922477 XP_973426.2 500 1.1e-47 PREDICTED: uncharacterized protein LOC662220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76879 176 1.7e-11 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25808 BF_2 260.14 5.18 2387 642928048 XP_008200135.1 818 2.2e-84 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 2.2e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04508//PF00038//PF04986//PF09392//PF10473//PF01008 Viral A-type inclusion protein repeat//Intermediate filament protein//Putative transposase//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Initiation factor 2 subunit family GO:0006313//GO:0044237//GO:0009405//GO:0016032//GO:0015031 transposition, DNA-mediated//cellular metabolic process//pathogenesis//viral process//protein transport GO:0005198//GO:0045502//GO:0008134//GO:0003677//GO:0004803//GO:0042803 structural molecule activity//dynein binding//transcription factor binding//DNA binding//transposase activity//protein homodimerization activity GO:0005882//GO:0005667//GO:0030286 intermediate filament//transcription factor complex//dynein complex -- -- Cluster-8309.25811 BF_2 248.00 13.55 1053 91077606 XP_973520.1 636 1.2e-63 PREDICTED: LDLR chaperone boca [Tribolium castaneum]>gi|270001559|gb|EEZ98006.1| hypothetical protein TcasGA2_TC000405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T9B6 585 4.1e-59 LDLR chaperone boca OS=Drosophila melanogaster GN=boca PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4357 Uncharacterized conserved protein (involved in mesoderm differentiation in humans) Cluster-8309.25812 BF_2 736.18 8.20 4043 642915003 XP_008190478.1 1917 1.4e-211 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915005|ref|XP_008190479.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915007|ref|XP_008190480.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|270002347|gb|EEZ98794.1| hypothetical protein TcasGA2_TC001358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 985 6.6e-105 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF07147//PF00501 Mitochondrial 28S ribosomal protein S30 (PDCD9)//AMP-binding enzyme GO:0042254//GO:0006412//GO:0008152 ribosome biogenesis//translation//metabolic process GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005739//GO:0005840 mitochondrion//ribosome KOG1176 Acyl-CoA synthetase Cluster-8309.25814 BF_2 76.38 0.84 4113 642915003 XP_008190478.1 1917 1.4e-211 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915005|ref|XP_008190479.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|642915007|ref|XP_008190480.1| PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum]>gi|270002347|gb|EEZ98794.1| hypothetical protein TcasGA2_TC001358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 985 6.7e-105 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501//PF07147 AMP-binding enzyme//Mitochondrial 28S ribosomal protein S30 (PDCD9) GO:0008152//GO:0042254//GO:0006412 metabolic process//ribosome biogenesis//translation GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0005840//GO:0005739 ribosome//mitochondrion KOG1176 Acyl-CoA synthetase Cluster-8309.25815 BF_2 194.97 1.26 6780 642916006 XP_008190854.1 2795 0.0e+00 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96923 134 5.3e-06 Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum GN=gnrA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25817 BF_2 1367.00 50.61 1417 332372854 AEE61569.1 1719 4.3e-189 unknown [Dendroctonus ponderosae] 815766998 XM_012367995.1 243 5.23315e-122 PREDICTED: Linepithema humile obg-like ATPase 1 (LOC105672805), transcript variant X4, mRNA K06942 K06942 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06942 Q8SWU7 1511 2.3e-166 Obg-like ATPase 1 OS=Drosophila melanogaster GN=CG1354 PE=1 SV=1 PF02421//PF01926//PF08477 Ferrous iron transport protein B//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG1491 Predicted GTP-binding protein (ODN superfamily) Cluster-8309.25821 BF_2 601.81 12.43 2313 642914581 XP_008190273.1 1779 7.8e-196 PREDICTED: uncharacterized protein LOC660922 isoform X1 [Tribolium castaneum] 642914580 XM_008192051.1 302 1.37369e-154 PREDICTED: Tribolium castaneum uncharacterized LOC660922 (LOC660922), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25826 BF_2 65.00 0.74 3940 642936940 XP_008198620.1 2491 3.6e-278 PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum]>gi|642936942|ref|XP_008198621.1| PREDICTED: angiomotin-like 2a isoform X1 [Tribolium castaneum] 642936943 XM_008200400.1 409 0 PREDICTED: Tribolium castaneum angiomotin-like protein 1 (LOC654850), transcript variant X3, mRNA K16819 AMOT angiomotin http://www.genome.jp/dbget-bin/www_bget?ko:K16819 Q4VCS5 521 4.1e-51 Angiomotin OS=Homo sapiens GN=AMOT PE=1 SV=1 PF05531 Nucleopolyhedrovirus P10 protein -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.25828 BF_2 6.00 1.24 489 73921480 AAZ94270.1 147 2.9e-07 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.2583 BF_2 5.00 1.24 456 641649131 XP_008184869.1 307 7.4e-26 PREDICTED: uncharacterized protein LOC103309922 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25830 BF_2 80.00 7.39 740 73921480 AAZ94270.1 589 2.4e-58 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 488 5.1e-48 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005488//GO:0020037//GO:0005506//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding//heme binding//iron ion binding//oxidoreductase activity -- -- -- -- Cluster-8309.25831 BF_2 434.50 33.18 835 91094063 XP_969813.1 573 2.0e-56 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016180|gb|EFA12628.1| cytochrome P450 6BR2 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 401 7.1e-38 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF15014//PF00067//PF15681 Ceroid-lipofuscinosis neuronal protein 5//Cytochrome P450//Lymphocyte activation family X GO:0051249//GO:0006955//GO:0055114//GO:0022008 regulation of lymphocyte activation//immune response//oxidation-reduction process//neurogenesis GO:0005488//GO:0020037//GO:0005506//GO:0016705//GO:0016491 binding//heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity GO:0005764 lysosome -- -- Cluster-8309.25833 BF_2 112.98 2.55 2144 73921480 AAZ94270.1 1305 6.6e-141 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 925 3.1e-98 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0055114//GO:0006955//GO:0051249 oxidation-reduction process//immune response//regulation of lymphocyte activation GO:0016491//GO:0016705//GO:0005506//GO:0020037//GO:0005488 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding//binding -- -- -- -- Cluster-8309.25834 BF_2 80.00 10.63 602 642925882 XP_008190661.1 403 7.3e-37 PREDICTED: probable cytochrome P450 6a17 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 362 1.7e-33 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067//PF05902 Cytochrome P450//4.1 protein C-terminal domain (CTD) GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005198//GO:0003779//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//structural molecule activity//actin binding//iron ion binding GO:0005856 cytoskeleton -- -- Cluster-8309.25835 BF_2 12.92 1.15 758 91094063 XP_969813.1 558 9.7e-55 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016180|gb|EFA12628.1| cytochrome P450 6BR2 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 416 1.2e-39 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005488//GO:0016705//GO:0005506//GO:0016491//GO:0020037 binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-8309.25836 BF_2 159.08 3.45 2214 73921480 AAZ94270.1 1269 1.0e-136 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 977 3.0e-104 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005488//GO:0016705//GO:0005506//GO:0016491//GO:0020037 binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-8309.25837 BF_2 8.51 0.51 985 91087165 XP_975370.1 471 1.5e-44 PREDICTED: protein max isoform X3 [Tribolium castaneum] -- -- -- -- -- K04453 MAX Max protein http://www.genome.jp/dbget-bin/www_bget?ko:K04453 P52162 242 2.3e-19 Protein max OS=Gallus gallus GN=MAX PE=3 SV=1 PF07716//PF00010//PF11095 Basic region leucine zipper//Helix-loop-helix DNA-binding domain//Gem-associated protein 7 (Gemin7) GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046983//GO:0043565 transcription factor activity, sequence-specific DNA binding//protein dimerization activity//sequence-specific DNA binding GO:0032797//GO:0005667 SMN complex//transcription factor complex KOG2483 Upstream transcription factor 2/L-myc-2 protein Cluster-8309.25839 BF_2 35.64 0.41 3967 642914301 XP_008201628.1 191 1.8e-11 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X1 [Tribolium castaneum] 462293333 APGK01053470.1 36 1.75101e-06 Dendroctonus ponderosae Seq01053480, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02723//PF03938//PF04037 Non-structural protein NS3/Small envelope protein E//Outer membrane protein (OmpH-like)//Domain of unknown function (DUF382) -- -- GO:0051082 unfolded protein binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.25841 BF_2 15.00 0.69 1198 546686406 ERL95679.1 603 9.3e-60 hypothetical protein D910_00109, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF01047 Transposase//MarR family GO:0006355//GO:0006313//GO:0015074 regulation of transcription, DNA-templated//transposition, DNA-mediated//DNA integration GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.25844 BF_2 5.00 4.27 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25845 BF_2 186.92 1.92 4359 91091668 XP_971563.1 1101 6.1e-117 PREDICTED: docking protein 2 [Tribolium castaneum]>gi|270001055|gb|EEZ97502.1| hypothetical protein TcasGA2_TC011346 [Tribolium castaneum] -- -- -- -- -- K17808 ZIM17, DNLZ, Tim15 mitochondrial protein import protein ZIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17808 A1L1P7 281 3.0e-23 DNL-type zinc finger protein OS=Danio rerio GN=dnlz PE=2 SV=1 PF05180//PF02174 DNL zinc finger//PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0008270//GO:0005158 zinc ion binding//insulin receptor binding GO:0005899 insulin receptor complex KOG3277 Uncharacterized conserved protein Cluster-8309.25849 BF_2 58.00 5.30 745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03325 Herpesvirus polymerase accessory protein GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337 DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.25852 BF_2 126.91 1.41 4053 642910771 XP_008193403.1 2110 5.7e-234 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00620//PF10297 RhoGAP domain//Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.25853 BF_2 58.00 6.11 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25855 BF_2 249.00 10.19 1309 189241734 XP_966970.2 661 1.9e-66 PREDICTED: ubiquinol-cytochrome-c reductase complex assembly factor 1 [Tribolium castaneum]>gi|270001140|gb|EEZ97587.1| hypothetical protein TcasGA2_TC011450 [Tribolium castaneum] -- -- -- -- -- K17662 CBP3, UQCC cytochrome b pre-mRNA-processing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17662 Q9W6I0 321 2.1e-28 Ubiquinol-cytochrome-c reductase complex assembly factor 1 OS=Xenopus laevis GN=uqcc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2873 Ubiquinol cytochrome c reductase assembly protein CBP3 Cluster-8309.25857 BF_2 9.00 0.60 915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25858 BF_2 291.00 6.78 2082 91084059 XP_967515.1 2369 2.7e-264 PREDICTED: nucleolar GTP-binding protein 2 [Tribolium castaneum]>gi|270008006|gb|EFA04454.1| hypothetical protein TcasGA2_TC014758 [Tribolium castaneum] -- -- -- -- -- K14537 NUG2, GNL2 nuclear GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14537 Q99LH1 1447 9.0e-159 Nucleolar GTP-binding protein 2 OS=Mus musculus GN=Gnl2 PE=2 SV=2 PF01926//PF03193//PF02421//PF00025 50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ferrous iron transport protein B//ADP-ribosylation factor family GO:0015684 ferrous iron transport GO:0015093//GO:0005525//GO:0003924 ferrous iron transmembrane transporter activity//GTP binding//GTPase activity GO:0016021//GO:0005730 integral component of membrane//nucleolus KOG2423 Nucleolar GTPase Cluster-8309.25859 BF_2 164.46 5.11 1633 385199930 AFI45013.1 718 5.9e-73 cytochrome P450 CYP410a1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P29981 565 1.3e-56 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.25860 BF_2 1002.99 81.97 799 817086814 XP_012266154.1 332 1.6e-28 PREDICTED: protein transport protein Sec61 subunit beta [Athalia rosae] 762139005 XM_011454539.1 79 4.25746e-31 PREDICTED: Crassostrea gigas protein transport protein Sec61 subunit beta-like (LOC105346081), mRNA K09481 SEC61B, SBH2 protein transport protein SEC61 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K09481 P60467 284 2.5e-24 Protein transport protein Sec61 subunit beta OS=Canis familiaris GN=SEC61B PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3457 Sec61 protein translocation complex, beta subunit Cluster-8309.25862 BF_2 1129.11 10.16 4935 189240067 XP_970199.2 2407 2.5e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.25876e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 4.9e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF05480//PF00083//PF08040//PF07690 Staphylococcus haemolytic protein//Sugar (and other) transporter//MNLL subunit//Major Facilitator Superfamily GO:0055085//GO:0006118//GO:0009405 transmembrane transport//obsolete electron transport//pathogenesis GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.25863 BF_2 7.00 0.72 696 -- -- -- -- -- 291170321 GU584934.1 46 8.14603e-13 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- PF08219 Outer membrane protein TOM13 -- -- -- -- GO:0005741 mitochondrial outer membrane -- -- Cluster-8309.25865 BF_2 21.48 0.49 2137 91092436 XP_968632.1 1512 6.5e-165 PREDICTED: laminin subunit gamma-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 1094 7.9e-118 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.25867 BF_2 234.58 10.08 1261 642937435 XP_008198833.1 676 3.4e-68 PREDICTED: STAGA complex 65 subunit gamma-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O94864 197 4.8e-14 STAGA complex 65 subunit gamma OS=Homo sapiens GN=SUPT7L PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.25868 BF_2 21.44 0.88 1304 91089157 XP_973708.1 545 5.4e-53 PREDICTED: uncharacterized protein LOC662524 [Tribolium castaneum]>gi|270012450|gb|EFA08898.1| hypothetical protein TcasGA2_TC006599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0032222//GO:1903818//GO:0030431 regulation of synaptic transmission, cholinergic//positive regulation of voltage-gated potassium channel activity//sleep GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.25869 BF_2 318.00 6.15 2450 642923389 XP_008193727.1 498 2.9e-47 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum]>gi|270007632|gb|EFA04080.1| hypothetical protein TcasGA2_TC014314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08678 184 3.0e-12 Adenylate cyclase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYR1 PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.25872 BF_2 1.00 0.93 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25874 BF_2 30.00 2.16 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25877 BF_2 677.00 7.67 3981 642935391 XP_008197992.1 3335 0.0e+00 PREDICTED: protein expanded [Tribolium castaneum]>gi|270013880|gb|EFA10328.1| hypothetical protein TcasGA2_TC012545 [Tribolium castaneum] 642935390 XM_008199770.1 356 0 PREDICTED: Tribolium castaneum protein expanded (LOC659267), mRNA K16683 EX protein expanded http://www.genome.jp/dbget-bin/www_bget?ko:K16683 Q07436 508 1.3e-49 Protein expanded OS=Drosophila melanogaster GN=ex PE=1 SV=3 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG4371 Membrane-associated protein tyrosine phosphatase PTP-BAS and related proteins, contain FERM domain Cluster-8309.25878 BF_2 286.28 9.57 1538 642928832 XP_008195580.1 1542 1.6e-168 PREDICTED: activating signal cointegrator 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15650 461 1.4e-44 Activating signal cointegrator 1 OS=Homo sapiens GN=TRIP4 PE=1 SV=4 PF06221 Putative zinc finger motif, C2HC5-type GO:0006355 regulation of transcription, DNA-templated GO:0008270 zinc ion binding GO:0005634 nucleus KOG2845 Activating signal cointegrator 1 Cluster-8309.25880 BF_2 7.00 0.83 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25882 BF_2 545.28 9.55 2675 642919741 XP_970851.2 1511 1.1e-164 PREDICTED: protein daughter of sevenless [Tribolium castaneum]>gi|270005903|gb|EFA02351.1| hypothetical protein TcasGA2_TC008021 [Tribolium castaneum] -- -- -- -- -- K09593 GAB1 GRB2-associated-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09593 Q9VZZ9 380 6.2e-35 Protein daughter of sevenless OS=Drosophila melanogaster GN=dos PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25883 BF_2 100.00 5.74 1016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25884 BF_2 109.93 3.14 1750 546681944 ERL91940.1 595 1.2e-58 hypothetical protein D910_09263, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0030431//GO:1903818//GO:0032222//GO:0016310//GO:0009069//GO:0007178 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic//phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.25886 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25887 BF_2 20.65 0.34 2861 91095137 XP_972151.1 803 1.4e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.4152e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 6.1e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.2589 BF_2 6.00 0.32 1068 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25892 BF_2 92.16 0.98 4227 478252787 ENN73180.1 1403 5.6e-152 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 4.8e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4780 Uncharacterized conserved protein Cluster-8309.25893 BF_2 9.02 0.42 1196 751781448 XP_011199893.1 357 3.1e-31 PREDICTED: trypsin-1-like [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q9JHJ7 223 4.4e-17 Testisin OS=Mus musculus GN=Prss21 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.25895 BF_2 8.00 0.97 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25898 BF_2 640.18 10.62 2809 642925510 XP_008194580.1 2213 4.5e-246 PREDICTED: proton-coupled folate transporter [Tribolium castaneum]>gi|270008860|gb|EFA05308.1| hypothetical protein TcasGA2_TC015466 [Tribolium castaneum] 749780227 XM_011146261.1 51 5.66605e-15 PREDICTED: Harpegnathos saltator solute carrier family 46 member 3-like (LOC105186216), mRNA K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6DCX5 259 7.0e-21 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.25902 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25906 BF_2 805.77 3.49 9946 642922511 XP_008193204.1 9536 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X3 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.54524e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1775 4.0e-196 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF00658//PF04625//PF00632//PF11547 Poly-adenylate binding protein, unique domain//DEC-1 protein, N-terminal region//HECT-domain (ubiquitin-transferase)//E3 ubiquitin ligase EDD GO:0016567//GO:0007304 protein ubiquitination//chorion-containing eggshell formation GO:0004842//GO:0043130//GO:0005213//GO:0003723 ubiquitin-protein transferase activity//ubiquitin binding//structural constituent of chorion//RNA binding GO:0042600//GO:0005576 chorion//extracellular region KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.25909 BF_2 26.49 5.77 479 642912272 XP_008200632.1 161 6.6e-09 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25911 BF_2 12.00 21.39 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25914 BF_2 925.99 27.15 1714 642933377 XP_008197391.1 1114 7.4e-119 PREDICTED: uncharacterized protein LOC660130 isoform X2 [Tribolium castaneum] 642933376 XM_008199169.1 245 4.91487e-123 PREDICTED: Tribolium castaneum uncharacterized LOC660130 (LOC660130), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00822//PF06687//PF13903//PF00335//PF03419 PMP-22/EMP/MP20/Claudin family//SUR7/PalI family//PMP-22/EMP/MP20/Claudin tight junction//Tetraspanin family//Sporulation factor SpoIIGA GO:0030436//GO:0006508 asexual sporulation//proteolysis GO:0004190 aspartic-type endopeptidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.25916 BF_2 56.87 3.00 1080 674304006 AIL23534.1 424 4.8e-39 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 286 2.0e-24 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.25919 BF_2 331.93 5.17 2974 91086799 XP_973439.1 2962 0.0e+00 PREDICTED: protein O-mannosyl-transferase 2 [Tribolium castaneum] 759111195 XM_011357078.1 54 1.2903e-16 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q29IL2 2307 2.4e-258 Protein O-mannosyl-transferase 2 OS=Drosophila pseudoobscura pseudoobscura GN=tw PE=3 SV=1 PF15886//PF02366//PF02815 Carbohydrate binding domain (family 32)//Dolichyl-phosphate-mannose-protein mannosyltransferase//MIR domain GO:0006493 protein O-linked glycosylation GO:0030246//GO:0000030 carbohydrate binding//mannosyltransferase activity GO:0016020//GO:0000136 membrane//alpha-1,6-mannosyltransferase complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.25920 BF_2 193.60 3.40 2666 642924514 XP_008194327.1 920 3.6e-96 PREDICTED: nuclear fragile X mental retardation-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXX8 333 1.7e-29 Nuclear fragile X mental retardation-interacting protein 1 OS=Mus musculus GN=Nufip1 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.25921 BF_2 48.56 1.28 1870 91086799 XP_973439.1 1673 1.2e-183 PREDICTED: protein O-mannosyl-transferase 2 [Tribolium castaneum] -- -- -- -- -- K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q29IL2 1218 2.9e-132 Protein O-mannosyl-transferase 2 OS=Drosophila pseudoobscura pseudoobscura GN=tw PE=3 SV=1 PF02815//PF02366 MIR domain//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0000030 mannosyltransferase activity GO:0016020//GO:0000136 membrane//alpha-1,6-mannosyltransferase complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.25922 BF_2 102.65 1.37 3423 270000870 EEZ97317.1 1789 8.0e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.4026e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.5e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.25924 BF_2 3030.16 70.19 2093 642919219 XP_969254.2 711 4.9e-72 PREDICTED: peroxiredoxin-5, mitochondrial [Tribolium castaneum] -- -- -- -- -- K11187 PRDX5 peroxiredoxin 5, atypical 2-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11187 Q9GLW9 460 2.6e-44 Peroxiredoxin-5, mitochondrial OS=Papio hamadryas GN=PRDX5 PE=2 SV=1 PF00578//PF00076//PF16367//PF08534 AhpC/TSA family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Redoxin GO:0055114 oxidation-reduction process GO:0016491//GO:0003676//GO:0016209 oxidoreductase activity//nucleic acid binding//antioxidant activity -- -- KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin Cluster-8309.25928 BF_2 34.99 2.07 996 478249796 ENN70303.1 448 7.3e-42 hypothetical protein YQE_12814, partial [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q8CF89 139 2.0e-07 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Mus musculus GN=Tab1 PE=1 SV=2 PF08119 Scorpion acidic alpha-KTx toxin family GO:0006810//GO:0009405 transport//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.25929 BF_2 49.01 3.28 913 478249796 ENN70303.1 508 7.4e-49 hypothetical protein YQE_12814, partial [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q8CF89 154 3.4e-09 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Mus musculus GN=Tab1 PE=1 SV=2 PF08119 Scorpion acidic alpha-KTx toxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.2593 BF_2 65.00 2.71 1290 642929176 XP_008195725.1 1199 7.8e-129 PREDICTED: syntaxin-16 [Tribolium castaneum] -- -- -- -- -- K08489 STX16 syntaxin 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08489 Q8BVI5 576 5.6e-58 Syntaxin-16 OS=Mus musculus GN=Stx16 PE=1 SV=3 PF00804//PF05739//PF00957 Syntaxin//SNARE domain//Synaptobrevin GO:0016192 vesicle-mediated transport GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0809 SNARE protein TLG2/Syntaxin 16 Cluster-8309.25930 BF_2 149.00 4.47 1681 332372540 AEE61412.1 1212 3.2e-130 unknown [Dendroctonus ponderosae] -- -- -- -- -- K04403 MAP3K7IP1, TAB1 TAK1-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04403 Q15750 641 2.1e-65 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 OS=Homo sapiens GN=TAB1 PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.25931 BF_2 51.00 1.90 1408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25934 BF_2 19.75 0.59 1680 642913250 XP_008201456.1 1439 1.5e-156 PREDICTED: probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum] 585692231 XM_006821346.1 56 5.58661e-18 PREDICTED: Saccoglossus kowalevskii probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase-like (LOC102807371), mRNA K03849 ALG8 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03849 Q9BVK2 1060 5.5e-114 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Homo sapiens GN=ALG8 PE=1 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG2576 Glucosyltransferase - Alg8p Cluster-8309.25935 BF_2 70.02 0.87 3638 91077034 XP_967567.1 1173 2.3e-125 PREDICTED: cysteine and histidine-rich domain-containing protein [Tribolium castaneum]>gi|270001750|gb|EEZ98197.1| hypothetical protein TcasGA2_TC000627 [Tribolium castaneum] -- -- -- -- -- K16729 CHORDC1, CHP1 cysteine and histidine-rich domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16729 Q9VCC0 980 2.2e-104 Cysteine and histidine-rich domain-containing protein OS=Drosophila melanogaster GN=CHORD PE=1 SV=1 PF03473//PF01082//PF00779 MOSC domain//Copper type II ascorbate-dependent monooxygenase, N-terminal domain//BTK motif GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0016715//GO:0003824//GO:0005507//GO:0004497//GO:0030170//GO:0030151 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//catalytic activity//copper ion binding//monooxygenase activity//pyridoxal phosphate binding//molybdenum ion binding -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.25939 BF_2 611.82 4.35 6168 91094947 XP_968721.1 2301 6.1e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.25944 BF_2 400.00 26.32 923 91079624 XP_967576.1 777 4.8e-80 PREDICTED: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Tribolium castaneum]>gi|642917723|ref|XP_008191346.1| PREDICTED: peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Tribolium castaneum]>gi|270004471|gb|EFA00919.1| hypothetical protein TcasGA2_TC003825 [Tribolium castaneum] -- -- -- -- -- K09578 PIN1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09578 P54353 517 2.8e-51 Putative peptidyl-prolyl cis-trans isomerase dodo OS=Drosophila melanogaster GN=dod PE=2 SV=3 PF13145//PF00639//PF00397 PPIC-type PPIASE domain//PPIC-type PPIASE domain//WW domain GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755//GO:0016853//GO:0005515 peptidyl-prolyl cis-trans isomerase activity//isomerase activity//protein binding -- -- KOG3259 Peptidyl-prolyl cis-trans isomerase Cluster-8309.25946 BF_2 113.91 1.04 4885 270014603 EFA11051.1 3565 0.0e+00 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 1.22841e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2408 7.8e-270 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00041//PF00102//PF00782 Fibronectin type III domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0008138 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.25949 BF_2 44.26 1.55 1479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25951 BF_2 56.65 0.94 2809 478253744 ENN74040.1 2544 1.9e-284 hypothetical protein YQE_09365, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13499//PF13833//PF13405//PF00036 EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.25952 BF_2 340.56 4.05 3802 642932100 XP_008196854.1 1534 3.3e-167 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.25173e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.9e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF07525//PF00622//PF01213 SOCS box//SPRY domain//Adenylate cyclase associated (CAP) N terminal GO:0035556//GO:0007010 intracellular signal transduction//cytoskeleton organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.25954 BF_2 0.83 6.00 242 642924598 XP_008194358.1 345 1.5e-30 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] -- -- -- -- -- K17388 ROCK2 Rho-associated protein kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17388 M3TYT0 189 7.8e-14 Rho-associated protein kinase 2 OS=Sus scrofa GN=ROCK2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.25958 BF_2 28.76 0.52 2616 91087855 XP_968688.1 2489 4.1e-278 PREDICTED: vacuolar protein sorting-associated protein 33A [Tribolium castaneum]>gi|270012007|gb|EFA08455.1| hypothetical protein TcasGA2_TC006102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63615 1434 3.7e-157 Vacuolar protein sorting-associated protein 33A OS=Rattus norvegicus GN=Vps33a PE=1 SV=1 PF00995//PF00895 Sec1 family//ATP synthase protein 8 GO:0015986//GO:0015992//GO:0006904//GO:0016192 ATP synthesis coupled proton transport//proton transport//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.25959 BF_2 19.00 12.77 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25960 BF_2 28.91 0.38 3448 642923271 XP_008193684.1 2245 1.1e-249 PREDICTED: protein FAN-like [Tribolium castaneum]>gi|642923273|ref|XP_008193685.1| PREDICTED: protein FAN-like [Tribolium castaneum] -- -- -- -- -- K18953 NSMAF, FAN factor associated with neutral sphingomyelinase activation http://www.genome.jp/dbget-bin/www_bget?ko:K18953 Q92636 1089 4.9e-117 Protein FAN OS=Homo sapiens GN=NSMAF PE=1 SV=2 PF11605//PF00400//PF16836//PF07569//PF08728 Vacuolar protein sorting protein 36 Vps36//WD domain, G-beta repeat//Shu complex component Psy3, DNA-binding description//TUP1-like enhancer of split//CRT10 GO:0000725//GO:0006355//GO:0006357 recombinational repair//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0043130//GO:0032266 protein binding//ubiquitin binding//phosphatidylinositol-3-phosphate binding GO:0005634//GO:0097196 nucleus//Shu complex KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.25967 BF_2 75.65 1.08 3216 91078858 XP_972061.1 1822 1.1e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 8.28718e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.4e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF05577//PF09138 Serine carboxypeptidase S28//Urm1 (Ubiquitin related modifier) GO:0006508//GO:0034227 proteolysis//tRNA thio-modification GO:0008236 serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.25970 BF_2 2.00 0.38 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25972 BF_2 225.00 2.02 4948 642919861 XP_008192099.1 1398 2.5e-151 PREDICTED: protein cramped isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRH6 770 6.8e-80 Translation factor waclaw, mitochondrial OS=Drosophila melanogaster GN=waw PE=3 SV=2 PF01926//PF00735//PF08477//PF00025//PF10662//PF00071//PF09589 50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//Ras family//HrpA pilus formation protein GO:0006576//GO:0009405//GO:0007264 cellular biogenic amine metabolic process//pathogenesis//small GTPase mediated signal transduction GO:0005525//GO:0005524 GTP binding//ATP binding GO:0005615 extracellular space KOG0462 Elongation factor-type GTP-binding protein Cluster-8309.25973 BF_2 196.15 3.48 2646 642920764 XP_008192550.1 1683 1.2e-184 PREDICTED: translation factor GUF1 homolog, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0WXB8 1437 1.7e-157 Translation factor GUF1 homolog, mitochondrial OS=Culex quinquefasciatus GN=CPIJ012086 PE=3 SV=1 PF01386//PF03144//PF06377 Ribosomal L25p family//Elongation factor Tu domain 2//Adipokinetic hormone GO:0042254//GO:0006412//GO:0007165 ribosome biogenesis//translation//signal transduction GO:0005525//GO:0003735//GO:0005179//GO:0008097 GTP binding//structural constituent of ribosome//hormone activity//5S rRNA binding GO:0005840 ribosome KOG0462 Elongation factor-type GTP-binding protein Cluster-8309.25974 BF_2 723.12 13.18 2583 642912647 XP_008200948.1 315 5.0e-26 PREDICTED: CREB/ATF bZIP transcription factor-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05791//PF01166//PF13631//PF01253//PF07716//PF00170 Bacillus haemolytic enterotoxin (HBL)//TSC-22/dip/bun family//Cytochrome b(N-terminal)/b6/petB//Translation initiation factor SUI1//Basic region leucine zipper//bZIP transcription factor GO:0006413//GO:0006118//GO:0006355//GO:0009405//GO:0006446 translational initiation//obsolete electron transport//regulation of transcription, DNA-templated//pathogenesis//regulation of translational initiation GO:0043565//GO:0009055//GO:0003700//GO:0003743//GO:0016491 sequence-specific DNA binding//electron carrier activity//transcription factor activity, sequence-specific DNA binding//translation initiation factor activity//oxidoreductase activity GO:0016020//GO:0005840//GO:0005667 membrane//ribosome//transcription factor complex -- -- Cluster-8309.25975 BF_2 2.00 0.56 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.25976 BF_2 36.88 1.09 1700 642940380 XP_008190315.1 501 8.9e-48 PREDICTED: uncharacterized protein LOC103312157, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.25979 BF_2 104.93 1.72 2842 91079112 XP_975371.1 1029 8.9e-109 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 1.3e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF04879//PF03370//PF03423//PF16760 Molybdopterin oxidoreductase Fe4S4 domain//Carbohydrate/starch-binding module (family 21)//Carbohydrate binding domain (family 25)//Starch/carbohydrate-binding module (family 53) GO:0055114 oxidation-reduction process GO:2001070//GO:0005515//GO:0016491 starch binding//protein binding//oxidoreductase activity -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.25980 BF_2 410.00 5.83 3231 642936791 XP_008198583.1 2256 5.3e-251 PREDICTED: parafibromin [Tribolium castaneum] 242014564 XM_002427912.1 162 1.28897e-76 Pediculus humanus corporis parafibromin, putative, mRNA K15175 CDC73 parafibromin http://www.genome.jp/dbget-bin/www_bget?ko:K15175 Q5ZLM0 1548 2.7e-170 Parafibromin OS=Gallus gallus GN=CDC73 PE=2 SV=1 PF00740 Parvovirus coat protein VP2 -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid KOG3786 RNA polymerase II assessory factor Cdc73p Cluster-8309.25982 BF_2 328.31 8.74 1859 270009743 EFA06191.1 1602 2.1e-175 hypothetical protein TcasGA2_TC009040 [Tribolium castaneum] 805761554 XM_012298644.1 131 1.25816e-59 PREDICTED: Megachile rotundata CCA tRNA nucleotidyltransferase 1, mitochondrial (LOC100882545), transcript variant X2, mRNA K00974 cca tRNA nucleotidyltransferase (CCA-adding enzyme) http://www.genome.jp/dbget-bin/www_bget?ko:K00974 Q96Q11 1074 1.4e-115 CCA tRNA nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=TRNT1 PE=1 SV=2 PF01743 Poly A polymerase head domain GO:0006396 RNA processing GO:0016779//GO:0003723 nucleotidyltransferase activity//RNA binding -- -- KOG2159 tRNA nucleotidyltransferase/poly(A) polymerase Cluster-8309.25986 BF_2 532.47 12.47 2073 332374952 AEE62617.1 1251 1.2e-134 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CW42 421 8.4e-40 Mitochondrial amidoxime-reducing component 1 OS=Mus musculus GN=Marc1 PE=1 SV=2 PF03473 MOSC domain -- -- GO:0030151//GO:0030170//GO:0003824 molybdenum ion binding//pyridoxal phosphate binding//catalytic activity -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.25989 BF_2 114.15 6.46 1026 568255492 ETN64256.1 282 1.3e-22 hypothetical protein AND_003999 [Anopheles darlingi] -- -- -- -- -- -- -- -- -- P82596 163 3.4e-10 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4297 C-type lectin Cluster-8309.25996 BF_2 380.89 3.77 4511 642912125 XP_008200817.1 1775 4.4e-195 PREDICTED: cell division cycle and apoptosis regulator protein 1-like [Tribolium castaneum] 572309672 XM_006620560.1 86 3.19692e-34 PREDICTED: Apis dorsata cell division cycle and apoptosis regulator protein 1-like (LOC102677857), transcript variant X2, mRNA -- -- -- -- Q8CH18 1238 3.4e-134 Cell division cycle and apoptosis regulator protein 1 OS=Mus musculus GN=Ccar1 PE=1 SV=1 PF01247 Ribosomal protein L35Ae GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG4246 Predicted DNA-binding protein, contains SAP domain Cluster-8309.25997 BF_2 84.06 0.38 9657 642918833 XP_008191605.1 8600 0.0e+00 PREDICTED: myotubularin-related protein 13 isoform X4 [Tribolium castaneum]>gi|270005687|gb|EFA02135.1| hypothetical protein TcasGA2_TC007785 [Tribolium castaneum] 642918832 XM_008193383.1 1529 0 PREDICTED: Tribolium castaneum myotubularin-related protein 13 (LOC659622), transcript variant X4, mRNA K18061 SBF1_2, MTMR5_13 myotubularin-related protein 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K18061 Q86WG5 3609 0.0e+00 Myotubularin-related protein 13 OS=Homo sapiens GN=SBF2 PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016311//GO:0035556 dephosphorylation//intracellular signal transduction GO:0005543//GO:0046872//GO:0016791 phospholipid binding//metal ion binding//phosphatase activity GO:0005622 intracellular KOG1090 Predicted dual-specificity phosphatase Cluster-8309.25999 BF_2 771.60 3.35 9932 642918833 XP_008191605.1 8700 0.0e+00 PREDICTED: myotubularin-related protein 13 isoform X4 [Tribolium castaneum]>gi|270005687|gb|EFA02135.1| hypothetical protein TcasGA2_TC007785 [Tribolium castaneum] 642918832 XM_008193383.1 1567 0 PREDICTED: Tribolium castaneum myotubularin-related protein 13 (LOC659622), transcript variant X4, mRNA K18061 SBF1_2, MTMR5_13 myotubularin-related protein 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K18061 Q86WG5 3686 0.0e+00 Myotubularin-related protein 13 OS=Homo sapiens GN=SBF2 PE=1 SV=1 PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016311//GO:0035556 dephosphorylation//intracellular signal transduction GO:0005543//GO:0046872//GO:0016791 phospholipid binding//metal ion binding//phosphatase activity GO:0005622 intracellular KOG1090 Predicted dual-specificity phosphatase Cluster-8309.2600 BF_2 31.00 4.73 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26003 BF_2 349.43 9.17 1881 189240485 XP_967921.2 1677 4.2e-184 PREDICTED: poly(A)-specific ribonuclease PARN [Tribolium castaneum]>gi|270011407|gb|EFA07855.1| hypothetical protein TcasGA2_TC005425 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 P69341 1069 5.5e-115 Poly(A)-specific ribonuclease PARN OS=Bos taurus GN=PARN PE=1 SV=2 PF01424//PF05669//PF08675//PF04857//PF14993 R3H domain//SOH1//RNA binding domain//CAF1 family ribonuclease//Neuropeptide S precursor protein GO:0007218//GO:0006355//GO:0051252//GO:0006402 neuropeptide signaling pathway//regulation of transcription, DNA-templated//regulation of RNA metabolic process//mRNA catabolic process GO:1901363//GO:0004535//GO:0003676//GO:0097159//GO:0046872//GO:0001104//GO:0003723 heterocyclic compound binding//poly(A)-specific ribonuclease activity//nucleic acid binding//organic cyclic compound binding//metal ion binding//RNA polymerase II transcription cofactor activity//RNA binding GO:0005576//GO:0005737//GO:0005634//GO:0016592 extracellular region//cytoplasm//nucleus//mediator complex KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.26004 BF_2 15.00 0.56 1403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26005 BF_2 3.00 2.52 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26006 BF_2 90.04 1.20 3426 642915779 XP_008200075.1 2130 2.3e-236 PREDICTED: uncharacterized protein LOC103314829 [Tribolium castaneum]>gi|270003127|gb|EEZ99574.1| hypothetical protein TcasGA2_TC001560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02525 135 2.0e-06 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13912//PF07776//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.26007 BF_2 35.31 0.94 1854 270003550 EEZ99997.1 666 7.1e-67 hypothetical protein TcasGA2_TC002800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NEL2 155 5.3e-09 Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens GN=SOWAHB PE=1 SV=1 PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.26008 BF_2 9.00 1.33 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26011 BF_2 799.55 52.36 926 642922849 XP_008200420.1 1108 2.0e-118 PREDICTED: C-type lectin isoform X1 [Tribolium castaneum] 815810415 XM_012370684.1 201 7.52364e-99 PREDICTED: Linepithema humile uncharacterized LOC105674405 (LOC105674405), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26012 BF_2 781.47 14.16 2596 642917050 XP_008191099.1 1801 2.4e-198 PREDICTED: ras-related GTP-binding protein C isoform X1 [Tribolium castaneum] 675669405 XM_002750631.3 99 1.08598e-41 PREDICTED: Callithrix jacchus Ras-related GTP binding C (RRAGC), mRNA K16186 RRAGC_D Ras-related GTP-binding protein C/D http://www.genome.jp/dbget-bin/www_bget?ko:K16186 Q99K70 1344 9.9e-147 Ras-related GTP-binding protein C OS=Mus musculus GN=Rragc PE=1 SV=1 PF00071//PF00025//PF04670//PF08477//PF01926 Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG3887 Predicted small GTPase involved in nuclear protein import Cluster-8309.26014 BF_2 915.68 63.54 890 189234762 XP_001814757.1 989 1.2e-104 PREDICTED: transmembrane emp24 domain-containing protein eca [Tribolium castaneum]>gi|270001537|gb|EEZ97984.1| hypothetical protein TcasGA2_TC000379 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4GMC3 915 1.9e-97 Transmembrane emp24 domain-containing protein eca OS=Drosophila persimilis GN=eca PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1690 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.26015 BF_2 233.00 11.12 1164 332375120 AEE62701.1 1211 2.8e-130 unknown [Dendroctonus ponderosae]>gi|546671559|gb|ERL83821.1| hypothetical protein D910_01073 [Dendroctonus ponderosae]>gi|546683663|gb|ERL93441.1| hypothetical protein D910_10733 [Dendroctonus ponderosae] -- -- -- -- -- K02906 RP-L3, MRPL3, rplC large subunit ribosomal protein L3 http://www.genome.jp/dbget-bin/www_bget?ko:K02906 Q99N95 592 7.0e-60 39S ribosomal protein L3, mitochondrial OS=Mus musculus GN=Mrpl3 PE=2 SV=1 PF00297//PF12937 Ribosomal protein L3//F-box-like GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3141 Mitochondrial/chloroplast ribosomal protein L3 Cluster-8309.26016 BF_2 122.00 12.04 711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26017 BF_2 65.00 1.50 2102 189237118 XP_972118.2 2235 9.4e-249 PREDICTED: serine/threonine-protein kinase polo [Tribolium castaneum]>gi|270008199|gb|EFA04647.1| polo [Tribolium castaneum] -- -- -- -- -- K06631 PLK1 polo-like kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06631 P52304 1705 1.1e-188 Serine/threonine-protein kinase polo OS=Drosophila melanogaster GN=polo PE=1 SV=2 PF00659//PF00069//PF07714 POLO box duplicated region//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005515//GO:0004672//GO:0004674//GO:0005524 protein binding//protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.26018 BF_2 481.20 8.99 2526 478249742 ENN70250.1 587 1.4e-57 hypothetical protein YQE_13033, partial [Dendroctonus ponderosae] -- -- -- -- -- K15455 KTI11, DPH3 diphthamide biosynthesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15455 Q9VGQ9 220 2.1e-16 DPH3 homolog OS=Drosophila melanogaster GN=CG14701 PE=3 SV=1 PF11705 DNA-directed RNA polymerase III subunit Rpc31 GO:0006359 regulation of transcription from RNA polymerase III promoter -- -- -- -- KOG2923 Uncharacterized conserved protein Cluster-8309.26022 BF_2 17.00 3.68 480 270015440 EFA11888.1 215 3.7e-15 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26024 BF_2 14.00 0.75 1072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26025 BF_2 138.63 2.64 2484 642937356 XP_008198803.1 3064 0.0e+00 PREDICTED: raf homolog serine/threonine-protein kinase phl [Tribolium castaneum] 195447877 XM_002071375.1 63 1.0683e-21 Drosophila willistoni GK25150 (Dwil\GK25150), mRNA K02644 PHL pole hole http://www.genome.jp/dbget-bin/www_bget?ko:K02644 P11346 1860 1.4e-206 Raf homolog serine/threonine-protein kinase phl OS=Drosophila melanogaster GN=phl PE=1 SV=6 PF13949//PF00130//PF07649//PF04111//PF16326//PF07714//PF00069//PF02196//PF06293 ALIX V-shaped domain binding to HIV//Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain//Autophagy protein Apg6//ABC transporter C-terminal domain//Protein tyrosine kinase//Protein kinase domain//Raf-like Ras-binding domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0055114//GO:0035556//GO:0007165//GO:0006468//GO:0006914 oxidation-reduction process//intracellular signal transduction//signal transduction//protein phosphorylation//autophagy GO:0016773//GO:0004672//GO:0047134//GO:0005057//GO:0003677//GO:0005524//GO:0005515 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity//receptor signaling protein activity//DNA binding//ATP binding//protein binding GO:0016020 membrane KOG0193 Serine/threonine protein kinase RAF Cluster-8309.26026 BF_2 267.89 9.39 1480 91079010 XP_974804.1 837 8.5e-87 PREDICTED: putative inositol monophosphatase 3 [Tribolium castaneum]>gi|270004173|gb|EFA00621.1| hypothetical protein TcasGA2_TC003497 [Tribolium castaneum] -- -- -- -- -- K15759 IMPAD1, IMPA3 inositol monophosphatase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15759 Q29JH0 568 5.4e-57 Putative inositol monophosphatase 3 OS=Drosophila pseudoobscura pseudoobscura GN=GA13929 PE=3 SV=2 PF04843//PF00459 Herpesvirus tegument protein, N-terminal conserved region//Inositol monophosphatase family GO:0006508//GO:0046854 proteolysis//phosphatidylinositol phosphorylation GO:0008233 peptidase activity -- -- KOG3853 Inositol monophosphatase Cluster-8309.26029 BF_2 478.10 8.89 2537 642912116 XP_008200813.1 1247 4.2e-134 PREDICTED: inorganic pyrophosphatase isoform X1 [Tribolium castaneum] 755993244 XM_011315162.1 85 6.43071e-34 PREDICTED: Fopius arisanus inorganic pyrophosphatase (LOC105272929), mRNA K01507 ppa inorganic pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01507 O77460 949 6.1e-101 Inorganic pyrophosphatase OS=Drosophila melanogaster GN=Nurf-38 PE=1 SV=3 PF00719 Inorganic pyrophosphatase GO:0006796//GO:0006119 phosphate-containing compound metabolic process//oxidative phosphorylation GO:0004427//GO:0000287 inorganic diphosphatase activity//magnesium ion binding GO:0005737 cytoplasm KOG1626 Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 Cluster-8309.26031 BF_2 25.22 1.17 1187 642931814 XP_008196744.1 595 7.8e-59 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q9VG82 369 5.2e-34 Probable cytochrome P450 9f2 OS=Drosophila melanogaster GN=Cyp9f2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.26034 BF_2 72.03 0.94 3483 189237997 XP_001812912.1 1051 3.0e-111 PREDICTED: dehydrogenase/reductase SDR family protein 7-like [Tribolium castaneum]>gi|270006651|gb|EFA03099.1| hypothetical protein TcasGA2_TC013008 [Tribolium castaneum] -- -- -- -- -- K11166 DHRS7B dehydrogenase/reductase SDR family member 7B http://www.genome.jp/dbget-bin/www_bget?ko:K11166 Q7Q732 796 4.6e-83 Dehydrogenase/reductase SDR family protein 7-like OS=Anopheles gambiae GN=AGAP005532 PE=3 SV=3 PF14972//PF01370//PF00106//PF02882//PF12242//PF02558 Mitochondrial morphogenesis regulator//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Ketopantoate reductase PanE/ApbA GO:0046487//GO:0009396//GO:0015940//GO:0008152//GO:0055114//GO:0007005 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//pantothenate biosynthetic process//metabolic process//oxidation-reduction process//mitochondrion organization GO:0004488//GO:0016491//GO:0003824//GO:0050662//GO:0008677 methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//catalytic activity//coenzyme binding//2-dehydropantoate 2-reductase activity GO:0031305 integral component of mitochondrial inner membrane KOG1205 Predicted dehydrogenase Cluster-8309.26035 BF_2 32.29 0.45 3321 189242339 XP_967217.2 1417 1.1e-153 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|642939487|ref|XP_008190837.1| PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016564|gb|EFA13010.1| hypothetical protein TcasGA2_TC001975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 292 1.2e-24 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF01238//PF00560 Leucine rich repeat//Phosphomannose isomerase type I//Leucine Rich Repeat GO:0005975//GO:0006000//GO:0006013 carbohydrate metabolic process//fructose metabolic process//mannose metabolic process GO:0005515//GO:0004476//GO:0008270 protein binding//mannose-6-phosphate isomerase activity//zinc ion binding -- -- -- -- Cluster-8309.26038 BF_2 15.04 4.16 438 478256019 ENN76218.1 261 1.5e-20 hypothetical protein YQE_07185, partial [Dendroctonus ponderosae] -- -- -- -- -- K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q148N0 128 1.7e-06 2-oxoglutarate dehydrogenase, mitochondrial OS=Bos taurus GN=OGDH PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.26041 BF_2 30.73 4.71 560 642925742 XP_008201567.1 355 2.5e-31 PREDICTED: LOW QUALITY PROTEIN: protein strawberry notch [Tribolium castaneum] 642925741 XM_008203345.1 56 1.78692e-18 PREDICTED: Tribolium castaneum protein strawberry notch (LOC655369), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26044 BF_2 81.64 1.06 3513 270015833 EFA12281.1 427 7.0e-39 hypothetical protein TcasGA2_TC005266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01637//PF00665//PF13304//PF08651//PF00910//PF07962 Archaeal ATPase//Integrase core domain//AAA domain, putative AbiEii toxin, Type IV TA system//DASH complex subunit Duo1//RNA helicase//Replication Fork Protection Component Swi3 GO:0006974//GO:0007067//GO:0007049//GO:0048478//GO:0015074 cellular response to DNA damage stimulus//mitotic nuclear division//cell cycle//replication fork protection//DNA integration GO:0005524//GO:0003723//GO:0003724 ATP binding//RNA binding//RNA helicase activity GO:0005634//GO:0072686//GO:0042729 nucleus//mitotic spindle//DASH complex -- -- Cluster-8309.26046 BF_2 4.94 1.23 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26047 BF_2 16.77 0.32 2510 91076548 XP_966358.1 499 2.2e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.7e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF04977//PF05093//PF07716//PF11095 Septum formation initiator//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Basic region leucine zipper//Gem-associated protein 7 (Gemin7) GO:0016226//GO:0006355//GO:0007049 iron-sulfur cluster assembly//regulation of transcription, DNA-templated//cell cycle GO:0051536//GO:0043565//GO:0003700 iron-sulfur cluster binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0032797//GO:0005737 transcription factor complex//SMN complex//cytoplasm KOG4020 Protein DRE2, required for cell viability Cluster-8309.26048 BF_2 27.99 1.96 886 501293239 BAN20577.1 242 5.0e-18 lipase 1 precursor [Riptortus pedestris] -- -- -- -- -- -- -- -- -- O46108 195 5.8e-14 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF01083 Cutinase GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.26051 BF_2 113.00 3.92 1493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26055 BF_2 58.76 1.01 2721 189237939 XP_001813105.1 493 1.2e-46 PREDICTED: ras-related protein Rab-5B [Tribolium castaneum]>gi|270008253|gb|EFA04701.1| Rab-protein 5 [Tribolium castaneum] 589949458 XM_006987325.1 126 1.11431e-56 PREDICTED: Peromyscus maniculatus bairdii RAB5B, member RAS oncogene family (Rab5b), mRNA K07888 RAB5B Ras-related protein Rab-5B http://www.genome.jp/dbget-bin/www_bget?ko:K07888 P61021 453 2.2e-43 Ras-related protein Rab-5B OS=Mus musculus GN=Rab5b PE=1 SV=1 PF00025//PF00071//PF16094//PF08477 ADP-ribosylation factor family//Ras family//Proteasome assembly chaperone 4//Ras of Complex, Roc, domain of DAPkinase GO:0043248//GO:0015031//GO:0007264 proteasome assembly//protein transport//small GTPase mediated signal transduction GO:0005525 GTP binding GO:0005783 endoplasmic reticulum KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.26057 BF_2 590.60 8.12 3330 189239692 XP_967139.2 1433 1.5e-155 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 65 1.11045e-22 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 929 1.7e-98 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF03293//PF00957//PF01080 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Synaptobrevin//Presenilin GO:0006351//GO:0019083//GO:0006144//GO:0016192//GO:0006206 transcription, DNA-templated//viral transcription//purine nucleobase metabolic process//vesicle-mediated transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0016021//GO:0005730 integral component of membrane//nucleolus KOG2736 Presenilin Cluster-8309.26058 BF_2 25.00 1.49 989 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26060 BF_2 33.52 1.11 1545 91083015 XP_974607.1 469 4.1e-44 PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|642923430|ref|XP_008193741.1| PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|270007020|gb|EFA03468.1| hypothetical protein TcasGA2_TC013464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 211 1.4e-15 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.26061 BF_2 268.28 4.26 2920 91078738 XP_967649.1 1032 4.1e-109 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] 195153530 XM_002017643.1 69 5.81007e-25 Drosophila persimilis GL17308 (Dper\GL17308), mRNA -- -- -- -- Q6DC39 632 4.0e-64 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.26062 BF_2 41.68 0.33 5647 478250909 ENN71394.1 603 4.4e-59 hypothetical protein YQE_11898, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9QX47 328 1.4e-28 Protein SON OS=Mus musculus GN=Son PE=1 SV=2 PF01585//PF05493 G-patch domain//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0003676//GO:0015078 nucleic acid binding//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.26065 BF_2 70.00 5.15 856 861633328 KMQ90923.1 323 1.9e-27 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.26066 BF_2 104.00 20.43 500 759051026 XP_011334612.1 563 1.7e-55 PREDICTED: uncharacterized protein LOC105277723 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26067 BF_2 235.31 4.57 2443 642910774 XP_008193404.1 944 5.5e-99 PREDICTED: ralA-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08773 RALBP1 RalA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08773 Q9VDG2 598 3.0e-60 RalA-binding protein 1 OS=Drosophila melanogaster GN=Rlip PE=1 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.26068 BF_2 5.00 0.35 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.26070 BF_2 17.00 0.56 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26071 BF_2 265.57 1.84 6320 780669505 XP_011694873.1 1341 1.3e-144 PREDICTED: methylcytosine dioxygenase TET2 isoform X2 [Wasmannia auropunctata] 642922119 XM_008194802.1 71 9.78189e-26 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 1073 6.4e-115 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26074 BF_2 21.00 2.10 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26075 BF_2 20.29 0.59 1715 478251138 ENN71614.1 811 1.0e-83 hypothetical protein YQE_11713, partial [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q6RY07 418 1.6e-39 Acidic mammalian chitinase OS=Rattus norvegicus GN=Chia PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.26076 BF_2 387.00 4.64 3779 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- -- -- Cluster-8309.26077 BF_2 5.42 0.66 631 642913478 XP_008201029.1 479 1.2e-45 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- K00902 E2.7.1.108 dolichol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00902 Q8R2Y3 278 9.7e-24 Dolichol kinase OS=Mus musculus GN=Dolk PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2468 Dolichol kinase Cluster-8309.26081 BF_2 440.74 4.67 4239 478253799 ENN74091.1 4823 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 2726 9.1e-307 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.26083 BF_2 82.00 7.24 761 642933223 XP_008197314.1 386 8.6e-35 PREDICTED: uncharacterized protein LOC103314104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TYJ0 178 4.6e-12 General odorant-binding protein 71 OS=Anopheles gambiae GN=Obp71 PE=3 SV=4 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.26084 BF_2 1724.92 12.88 5890 642939380 XP_008193163.1 2477 2.3e-276 PREDICTED: hemicentin-1 isoform X3 [Tribolium castaneum] 642939379 XM_008194941.1 105 1.14643e-44 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X3, mRNA -- -- -- -- Q8WZ42 332 5.0e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF00895//PF05510//PF00558//PF06377//PF13895//PF00957 ATP synthase protein 8//Sarcoglycan alpha/epsilon//Vpu protein//Adipokinetic hormone//Immunoglobulin domain//Synaptobrevin GO:0019076//GO:0016192//GO:0007165//GO:0015992//GO:0032801//GO:0015986//GO:0006812 viral release from host cell//vesicle-mediated transport//signal transduction//proton transport//receptor catabolic process//ATP synthesis coupled proton transport//cation transport GO:0005515//GO:0005179//GO:0005261//GO:0015078 protein binding//hormone activity//cation channel activity//hydrogen ion transmembrane transporter activity GO:0016021//GO:0016012//GO:0033644//GO:0000276 integral component of membrane//sarcoglycan complex//host cell membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.26087 BF_2 6.00 1.28 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26090 BF_2 295.06 4.86 2829 270013097 EFA09545.1 3781 0.0e+00 hypothetical protein TcasGA2_TC011654 [Tribolium castaneum] 194740873 XM_001952880.1 419 0 Drosophila ananassae GF17478 (Dana\GF17478), mRNA K13763 PDE6N cGMP-specific 3',5'-cyclic phosphodiesterase, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K13763 B4K9L4 3078 0.0e+00 cGMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila mojavensis GN=Pde6 PE=3 SV=1 PF13185//PF00233//PF01590//PF04542//PF13492 GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//Sigma-70 region 2//GAF domain GO:0006355//GO:0006352//GO:0007165//GO:0006144 regulation of transcription, DNA-templated//DNA-templated transcription, initiation//signal transduction//purine nucleobase metabolic process GO:0016987//GO:0003700//GO:0004114//GO:0003677//GO:0005515 sigma factor activity//transcription factor activity, sequence-specific DNA binding//3',5'-cyclic-nucleotide phosphodiesterase activity//DNA binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.26091 BF_2 48.67 0.70 3192 91094219 XP_973249.1 584 4.0e-57 PREDICTED: uncharacterized protein C9orf85 homolog isoform X2 [Tribolium castaneum]>gi|270016216|gb|EFA12662.1| hypothetical protein TcasGA2_TC002245 [Tribolium castaneum] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q5TZ51 297 3.1e-25 Protein Mpv17 OS=Danio rerio GN=mpv17 PE=2 SV=1 PF01990//PF04117 ATP synthase (F/14-kDa) subunit//Mpv17 / PMP22 family GO:0034220 ion transmembrane transport -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.26092 BF_2 5.00 0.41 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26093 BF_2 302.62 2.88 4686 546674891 ERL86177.1 2545 2.4e-284 hypothetical protein D910_03590 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R3L5 704 2.9e-72 Solute carrier organic anion transporter family member 3A1 OS=Mus musculus GN=Slco3a1 PE=2 SV=1 PF00050//PF07648//PF09446//PF03137//PF07690 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//VMA21-like domain//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0070072//GO:0055085//GO:0006810 vacuolar proton-transporting V-type ATPase complex assembly//transmembrane transport//transport GO:0005215//GO:0005515 transporter activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG3626 Organic anion transporter Cluster-8309.26094 BF_2 6.00 17.79 270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26096 BF_2 300.86 8.92 1698 576251521 AHH29345.1 433 6.8e-40 vacuolar H[+]-ATPase E subunit [Leptinotarsa decemlineata] -- -- -- -- -- K02150 ATPeV1E, ATP6E V-type H+-transporting ATPase subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K02150 P31402 292 6.3e-25 V-type proton ATPase subunit E OS=Manduca sexta GN=VHA26 PE=2 SV=1 PF01991 ATP synthase (E/31 kDa) subunit GO:0015992//GO:0006119//GO:0015991 proton transport//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961 proton-transporting ATPase activity, rotational mechanism GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1664 Vacuolar H+-ATPase V1 sector, subunit E Cluster-8309.26099 BF_2 119.00 10.51 761 91082423 XP_970313.1 900 2.1e-94 PREDICTED: DNA-directed RNA polymerase II subunit RPB7 [Tribolium castaneum]>gi|270007516|gb|EFA03964.1| hypothetical protein TcasGA2_TC014109 [Tribolium castaneum] -- -- -- -- -- K03015 RPB7, POLR2G DNA-directed RNA polymerase II subunit RPB7 http://www.genome.jp/dbget-bin/www_bget?ko:K03015 P62488 748 3.7e-78 DNA-directed RNA polymerase II subunit RPB7 OS=Mus musculus GN=Polr2g PE=2 SV=1 PF03876//PF00575 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//S1 RNA binding domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003676//GO:0003723//GO:0003899 nucleic acid binding//RNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3298 DNA-directed RNA polymerase subunit E' Cluster-8309.26101 BF_2 336.94 6.40 2489 642916262 XP_008190953.1 1208 1.4e-129 PREDICTED: thyrotropin-releasing hormone receptor isoform X3 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.7e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.26102 BF_2 1082.09 17.14 2928 478257160 ENN77323.1 1838 1.4e-202 hypothetical protein YQE_06149, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IVI9 340 2.9e-30 Nostrin OS=Homo sapiens GN=NOSTRIN PE=1 SV=2 PF02185 Hr1 repeat GO:0007165 signal transduction -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.26104 BF_2 30.53 0.50 2849 478253990 ENN74282.1 1734 1.6e-190 hypothetical protein YQE_09254, partial [Dendroctonus ponderosae]>gi|546673736|gb|ERL85292.1| hypothetical protein D910_02713 [Dendroctonus ponderosae] -- -- -- -- -- K06639 CDC14 cell division cycle 14 http://www.genome.jp/dbget-bin/www_bget?ko:K06639 Q6GQT0 1212 2.2e-131 Dual specificity protein phosphatase CDC14A OS=Mus musculus GN=Cdc14a PE=2 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.26105 BF_2 284.09 5.53 2436 91082801 XP_967900.1 2758 2.5e-309 PREDICTED: PAX3- and PAX7-binding protein 1 [Tribolium castaneum]>gi|270007581|gb|EFA04029.1| hypothetical protein TcasGA2_TC014258 [Tribolium castaneum] -- -- -- -- -- K13211 GCFC GC-rich sequence DNA-binding factor http://www.genome.jp/dbget-bin/www_bget?ko:K13211 P58501 803 5.0e-84 PAX3- and PAX7-binding protein 1 OS=Mus musculus GN=Paxbp1 PE=1 SV=3 PF07842 GC-rich sequence DNA-binding factor-like protein GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2136 Transcriptional regulators binding to the GC-rich sequences Cluster-8309.26108 BF_2 87.00 1.19 3354 642922843 XP_008193348.1 2882 0.0e+00 PREDICTED: sodium- and chloride-dependent GABA transporter 1 [Tribolium castaneum]>gi|642922845|ref|XP_008193349.1| PREDICTED: sodium- and chloride-dependent GABA transporter 1 [Tribolium castaneum]>gi|270007115|gb|EFA03563.1| hypothetical protein TcasGA2_TC013646 [Tribolium castaneum] 808123449 XM_012309570.1 161 4.81442e-76 PREDICTED: Bombus terrestris sodium- and chloride-dependent GABA transporter 1-like (LOC100648748), mRNA K05034 SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA) member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05034 P30531 1767 1.1e-195 Sodium- and chloride-dependent GABA transporter 1 OS=Homo sapiens GN=SLC6A1 PE=2 SV=2 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3660 Sodium-neurotransmitter symporter Cluster-8309.26110 BF_2 102.00 5.85 1016 304367616 ADM26622.1 870 8.6e-91 ferritin [Scylla paramamosain] 304367615 HM150719.1 748 0 Scylla paramamosain ferritin mRNA, complete cds K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 Q26061 681 2.9e-70 Ferritin OS=Pacifastacus leniusculus PE=1 SV=1 PF02915//PF00210 Rubrerythrin//Ferritin-like domain GO:0006879//GO:0055114 cellular iron ion homeostasis//oxidation-reduction process GO:0008199//GO:0046872//GO:0016491 ferric iron binding//metal ion binding//oxidoreductase activity -- -- KOG2332 Ferritin Cluster-8309.26111 BF_2 57.88 0.67 3920 546682290 ERL92248.1 263 8.1e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 3.0e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.26113 BF_2 326.63 1.16 12086 642913340 XP_008195316.1 9080 0.0e+00 PREDICTED: WD repeat and FYVE domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270002019|gb|EEZ98466.1| hypothetical protein TcasGA2_TC000957 [Tribolium castaneum] 572266379 XM_006611237.1 593 0 PREDICTED: Apis dorsata WD repeat and FYVE domain-containing protein 3-like (LOC102679853), mRNA -- -- -- -- Q6VNB8 2989 0.0e+00 WD repeat and FYVE domain-containing protein 3 OS=Mus musculus GN=Wdfy3 PE=1 SV=1 PF01363//PF13742//PF00400 FYVE zinc finger//OB-fold nucleic acid binding domain//WD domain, G-beta repeat -- -- GO:0003676//GO:0005515//GO:0046872 nucleic acid binding//protein binding//metal ion binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.26118 BF_2 212.87 14.92 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26120 BF_2 89.76 0.59 6639 642923720 XP_008193855.1 1439 5.9e-156 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0FGR8 565 5.4e-56 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.26122 BF_2 100.22 0.66 6642 270006670 EFA03118.1 666 2.6e-66 hypothetical protein TcasGA2_TC013028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01349//PF02205 Flavivirus non-structural protein NS4B//WH2 motif GO:0006396//GO:0006370//GO:0009451//GO:0006144 RNA processing//7-methylguanosine mRNA capping//RNA modification//purine nucleobase metabolic process GO:0004483//GO:0017111//GO:0004252//GO:0016817//GO:0003968//GO:0070008//GO:0003779//GO:0004482 mRNA (nucleoside-2'-O-)-methyltransferase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//RNA-directed RNA polymerase activity//serine-type exopeptidase activity//actin binding//mRNA (guanine-N7-)-methyltransferase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.26128 BF_2 12.39 1.17 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26129 BF_2 2984.87 18.79 6931 270013942 EFA10390.1 1611 7.0e-176 hypothetical protein TcasGA2_TC012621 [Tribolium castaneum] 642935672 XM_969594.3 364 0 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 11 (LOC663555), mRNA K03036 PSMD11, RPN6 26S proteasome regulatory subunit N6 http://www.genome.jp/dbget-bin/www_bget?ko:K03036 Q7KLV9 1341 5.9e-146 26S proteasome non-ATPase regulatory subunit 11 OS=Drosophila melanogaster GN=Rpn6 PE=1 SV=1 PF01399//PF05823//PF05524 PCI domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//PEP-utilising enzyme, N-terminal GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.2613 BF_2 15.00 1.11 853 642934279 XP_008200904.1 323 1.9e-27 PREDICTED: centromere protein S-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D084 168 7.5e-11 Centromere protein S OS=Mus musculus GN=Apitd1 PE=2 SV=1 PF02969//PF00125//PF02291//PF04628 TATA box binding protein associated factor (TAF)//Core histone H2A/H2B/H3/H4//Transcription initiation factor IID, 31kD subunit//Sedlin, N-terminal conserved region GO:0006352//GO:0006888 DNA-templated transcription, initiation//ER to Golgi vesicle-mediated transport GO:0003677 DNA binding GO:0005634//GO:0005622 nucleus//intracellular -- -- Cluster-8309.26130 BF_2 158.57 2.80 2654 642919741 XP_970851.2 1468 1.0e-159 PREDICTED: protein daughter of sevenless [Tribolium castaneum]>gi|270005903|gb|EFA02351.1| hypothetical protein TcasGA2_TC008021 [Tribolium castaneum] -- -- -- -- -- K09593 GAB1 GRB2-associated-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09593 Q9VZZ9 369 1.2e-33 Protein daughter of sevenless OS=Drosophila melanogaster GN=dos PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26131 BF_2 323.00 33.13 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26133 BF_2 307.16 10.85 1471 478260052 ENN79837.1 816 2.3e-84 hypothetical protein YQE_03659, partial [Dendroctonus ponderosae]>gi|546676810|gb|ERL87756.1| hypothetical protein D910_05145 [Dendroctonus ponderosae] 556754727 XM_005972665.1 93 1.31811e-38 PREDICTED: Pantholops hodgsonii TRK-fused gene (TFG), mRNA K09292 TFG protein TFG http://www.genome.jp/dbget-bin/www_bget?ko:K09292 Q92734 475 3.3e-46 Protein TFG OS=Homo sapiens GN=TFG PE=1 SV=2 PF00564 PB1 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26134 BF_2 3.00 1.86 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26136 BF_2 190.00 5.13 1836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26143 BF_2 100.10 4.62 1194 91079286 XP_972784.1 697 1.2e-70 PREDICTED: syntaxin-17 [Tribolium castaneum]>gi|270004314|gb|EFA00762.1| hypothetical protein TcasGA2_TC003648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D0I4 179 5.6e-12 Syntaxin-17 OS=Mus musculus GN=Stx17 PE=1 SV=1 PF04728//PF05531//PF06009//PF05739//PF03462 Lipoprotein leucine-zipper//Nucleopolyhedrovirus P10 protein//Laminin Domain II//SNARE domain//PCRF domain GO:0007155//GO:0006415//GO:0006449 cell adhesion//translational termination//regulation of translational termination GO:0005515//GO:0016149 protein binding//translation release factor activity, codon specific GO:0018444//GO:0005737//GO:0005840//GO:0019028//GO:0019867 translation release factor complex//cytoplasm//ribosome//viral capsid//outer membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.26144 BF_2 26.91 0.32 3775 676472292 XP_009059444.1 402 6.0e-36 hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea]>gi|556101324|gb|ESO89976.1| hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q5MCW4 395 1.6e-36 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF00096//PF02892//PF01527//PF13912//PF04218//PF16622//PF02701//PF13465//PF05443//PF15898 Zinc finger, C2H2 type//BED zinc finger//Transposase//C2H2-type zinc finger//CENP-B N-terminal DNA-binding domain//zinc-finger C2H2-type//Dof domain, zinc finger//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//cGMP-dependent protein kinase interacting domain GO:0006355//GO:0006313 regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0008270//GO:0019901//GO:0003677//GO:0046872//GO:0004803 zinc ion binding//protein kinase binding//DNA binding//metal ion binding//transposase activity -- -- -- -- Cluster-8309.26146 BF_2 27.00 1.53 1023 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26147 BF_2 29.15 0.36 3655 642923758 XP_008193872.1 668 8.3e-67 PREDICTED: activating signal cointegrator 1 complex subunit 1-like [Tribolium castaneum]>gi|270006936|gb|EFA03384.1| hypothetical protein TcasGA2_TC013370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLU6 316 2.2e-27 Succinate dehydrogenase assembly factor 4, mitochondrial OS=Drosophila melanogaster GN=Sirup PE=3 SV=2 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG2814 Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) Cluster-8309.26149 BF_2 21.62 0.32 3142 270003908 EFA00356.1 178 4.7e-10 hypothetical protein TcasGA2_TC003198 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54HA4 138 8.4e-07 GATA zinc finger domain-containing protein 15 (Fragment) OS=Dictyostelium discoideum GN=gtaO PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26150 BF_2 58.79 0.93 2920 91075962 XP_969092.1 1413 2.7e-153 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1185 3.0e-128 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF09177//PF04851//PF07517//PF00270 Syntaxin 6, N-terminal//Type III restriction enzyme, res subunit//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.26151 BF_2 41.53 0.92 2172 91075962 XP_969092.1 1385 3.5e-150 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1157 4.0e-125 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF07517//PF10473//PF09177//PF04851//PF00270 SecA DEAD-like domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0042803//GO:0003676//GO:0045502//GO:0008134//GO:0005524//GO:0003677//GO:0016787 protein homodimerization activity//nucleic acid binding//dynein binding//transcription factor binding//ATP binding//DNA binding//hydrolase activity GO:0016020//GO:0005667//GO:0030286 membrane//transcription factor complex//dynein complex KOG0351 ATP-dependent DNA helicase Cluster-8309.26153 BF_2 40.36 0.63 2987 242022338 XP_002431597.1 899 1.1e-93 ATP-dependent DNA helicase Q1, putative [Pediculus humanus corporis]>gi|212516905|gb|EEB18859.1| ATP-dependent DNA helicase Q1, putative [Pediculus humanus corporis] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 Q6AYJ1 798 2.3e-83 ATP-dependent DNA helicase Q1 OS=Rattus norvegicus GN=Recql PE=2 SV=1 PF04851//PF10473//PF09177//PF07517//PF00270 Type III restriction enzyme, res subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0008134//GO:0045502//GO:0016787//GO:0003677//GO:0005524//GO:0003676//GO:0042803 transcription factor binding//dynein binding//hydrolase activity//DNA binding//ATP binding//nucleic acid binding//protein homodimerization activity GO:0005667//GO:0030286//GO:0016020 transcription factor complex//dynein complex//membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.26154 BF_2 68.72 1.43 2298 91075962 XP_969092.1 1413 2.1e-153 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1185 2.4e-128 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF04851//PF09177//PF07517//PF00270 Type III restriction enzyme, res subunit//Syntaxin 6, N-terminal//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.26155 BF_2 10.38 0.82 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26156 BF_2 1069.48 36.03 1529 646700412 KDR10573.1 1620 1.4e-177 Adenylosuccinate synthetase [Zootermopsis nevadensis] -- -- -- -- -- K01939 purA, ADSS adenylosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01939 Q17G75 1578 4.3e-174 Adenylosuccinate synthetase OS=Aedes aegypti GN=AAEL003161 PE=3 SV=1 PF01640//PF00709 Peptidase C10 family//Adenylosuccinate synthetase GO:0006508//GO:0006522//GO:0006164//GO:0006531//GO:0006144 proteolysis//alanine metabolic process//purine nucleotide biosynthetic process//aspartate metabolic process//purine nucleobase metabolic process GO:0004019//GO:0005525//GO:0008234 adenylosuccinate synthase activity//GTP binding//cysteine-type peptidase activity -- -- KOG1355 Adenylosuccinate synthase Cluster-8309.26158 BF_2 226.83 10.05 1231 91090510 XP_969573.1 1112 9.1e-119 PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum]>gi|642935364|ref|XP_008197982.1| PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q8IYP9 225 2.7e-17 Palmitoyltransferase ZDHHC23 OS=Homo sapiens GN=ZDHHC23 PE=1 SV=3 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.26159 BF_2 9.37 0.37 1345 332372842 AEE61563.1 742 8.0e-76 unknown [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q8IYP9 225 2.9e-17 Palmitoyltransferase ZDHHC23 OS=Homo sapiens GN=ZDHHC23 PE=1 SV=3 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.26160 BF_2 36.00 0.70 2444 270015620 EFA12068.1 149 8.4e-07 hypothetical protein TcasGA2_TC005201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26162 BF_2 32.15 0.34 4274 270004253 EFA00701.1 1707 3.2e-187 hypothetical protein TcasGA2_TC003580 [Tribolium castaneum] 642916514 XM_008192851.1 777 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X3, mRNA K04874 KCNA1 potassium voltage-gated channel Shaker-related subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04874 P08510 1533 2.0e-168 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.26164 BF_2 15.00 0.57 1395 646717332 KDR20226.1 380 7.8e-34 hypothetical protein L798_05535, partial [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 370 4.6e-34 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF06467//PF05495//PF02176//PF00096//PF16622//PF00412//PF02892//PF13912//PF13465 MYM-type Zinc finger with FCS sequence motif//CHY zinc finger//TRAF-type zinc finger//Zinc finger, C2H2 type//zinc-finger C2H2-type//LIM domain//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.26165 BF_2 212.63 28.61 598 91093076 XP_968784.1 693 1.7e-70 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 584 3.1e-59 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26166 BF_2 2.02 0.40 496 91080431 XP_968599.1 211 1.1e-14 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26168 BF_2 564.10 12.54 2169 642910961 XP_008193484.1 1080 8.2e-115 PREDICTED: leukocyte elastase inhibitor-like [Tribolium castaneum]>gi|642910963|ref|XP_008193485.1| PREDICTED: leukocyte elastase inhibitor-like [Tribolium castaneum]>gi|642910965|ref|XP_008193486.1| PREDICTED: leukocyte elastase inhibitor-like [Tribolium castaneum]>gi|270015161|gb|EFA11609.1| serpin peptidase inhibitor 30 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TMP0 477 2.8e-46 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 PF05188 MutS domain II GO:0006298 mismatch repair GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- -- -- Cluster-8309.26171 BF_2 11.41 0.65 1017 -- -- -- -- -- 820855726 XM_012489619.1 67 2.56334e-24 PREDICTED: Apis florea hepatic leukemia factor (LOC100863581), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26173 BF_2 895.55 17.35 2447 478263594 ENN81908.1 2296 9.2e-256 hypothetical protein YQE_01712, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- D2XV59 1841 2.2e-204 GTP-binding protein 1 OS=Rattus norvegicus GN=Gtpbp1 PE=1 SV=1 PF00005//PF03144//PF01926//PF10662 ABC transporter//Elongation factor Tu domain 2//50S ribosome-binding GTPase//Ethanolamine utilisation - propanediol utilisation GO:0006576 cellular biogenic amine metabolic process GO:0005525//GO:0005524//GO:0016887 GTP binding//ATP binding//ATPase activity -- -- KOG1143 Predicted translation elongation factor Cluster-8309.26174 BF_2 189.17 2.49 3460 478250812 ENN71304.1 2971 0.0e+00 hypothetical protein YQE_12229, partial [Dendroctonus ponderosae] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1638 1.1e-180 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF07648//PF00050//PF00093//PF05375 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) -- -- GO:0005515//GO:0030414 protein binding//peptidase inhibitor activity -- -- -- -- Cluster-8309.26175 BF_2 278.33 3.26 3856 642931832 XP_008196749.1 1219 1.1e-130 PREDICTED: GPI inositol-deacylase [Tribolium castaneum]>gi|270011727|gb|EFA08175.1| hypothetical protein TcasGA2_TC005802 [Tribolium castaneum] -- -- -- -- -- K05294 PGAP1 glycosylphosphatidylinositol deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K05294 Q75T13 633 4.1e-64 GPI inositol-deacylase OS=Homo sapiens GN=PGAP1 PE=1 SV=1 PF07819//PF07859//PF07074//PF01764 PGAP1-like protein//alpha/beta hydrolase fold//Translocon-associated protein, gamma subunit (TRAP-gamma)//Lipase (class 3) GO:0009987//GO:0006505//GO:0008152//GO:0006613//GO:0006886//GO:0006629 cellular process//GPI anchor metabolic process//metabolic process//cotranslational protein targeting to membrane//intracellular protein transport//lipid metabolic process GO:0016787//GO:0016788 hydrolase activity//hydrolase activity, acting on ester bonds GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG3724 Negative regulator of COPII vesicle formation Cluster-8309.26176 BF_2 6.00 0.40 916 642935576 XP_008198066.1 241 6.7e-18 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.26179 BF_2 17.36 0.50 1731 801399331 XP_012060168.1 186 3.0e-11 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2618 BF_2 11.00 0.34 1640 649572209 NP_001280511.1 1387 1.6e-150 tachykinin-like peptides receptor 86C [Tribolium castaneum]>gi|530445637|gb|AGT29556.1| natalisin receptor [Tribolium castaneum] -- -- -- -- -- K04225 TAKR tachykinin-like receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04225 P30974 915 3.5e-97 Tachykinin-like peptides receptor 86C OS=Drosophila melanogaster GN=TkR86C PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4219 G protein-coupled receptor Cluster-8309.26180 BF_2 79.99 2.44 1660 642930894 XP_008196130.1 351 2.1e-30 PREDICTED: protein phosphatase inhibitor 2-like [Tribolium castaneum]>gi|270011942|gb|EFA08390.1| hypothetical protein TcasGA2_TC006037 [Tribolium castaneum] -- -- -- -- -- K16833 PPP1R2, IPP2 protein phosphatase inhibitor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16833 P11845 205 7.5e-15 Protein phosphatase inhibitor 2 OS=Oryctolagus cuniculus GN=PPP1R2 PE=1 SV=3 PF04979//PF04272 Protein phosphatase inhibitor 2 (IPP-2)//Phospholamban GO:0009966//GO:0006816//GO:0050794//GO:0006810//GO:0043666 regulation of signal transduction//calcium ion transport//regulation of cellular process//transport//regulation of phosphoprotein phosphatase activity GO:0004864//GO:0005246//GO:0042030 protein phosphatase inhibitor activity//calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane KOG4041 Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 Cluster-8309.26181 BF_2 1.00 0.36 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26182 BF_2 52.50 0.55 4300 270003696 EFA00144.1 1416 1.8e-153 hypothetical protein TcasGA2_TC002965 [Tribolium castaneum] 746862194 XM_011063702.1 155 1.33927e-72 PREDICTED: Acromyrmex echinatior uncharacterized LOC105150543 (LOC105150543), mRNA K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q8VHQ2 432 9.3e-41 Suppressor of cytokine signaling 7 OS=Mus musculus GN=Socs7 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.26186 BF_2 825.22 51.31 960 189234193 XP_970277.2 759 6.1e-78 PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [Tribolium castaneum]>gi|270002697|gb|EEZ99144.1| hypothetical protein TcasGA2_TC012925 [Tribolium castaneum] -- -- -- -- -- K08967 mtnD, mtnZ, ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K08967 E0W481 669 6.8e-69 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Pediculus humanus subsp. corporis GN=Phum_PHUM616140 PE=3 SV=1 PF02311//PF00190//PF03079 AraC-like ligand binding domain//Cupin//ARD/ARD' family GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity GO:0005634 nucleus KOG2107 Uncharacterized conserved protein, contains double-stranded beta-helix domain Cluster-8309.26187 BF_2 3.00 0.60 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26188 BF_2 32.05 1.32 1306 642932344 XP_008197074.1 164 8.2e-09 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26189 BF_2 17.10 0.61 1451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2619 BF_2 5.33 0.37 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02096 60Kd inner membrane protein GO:0051205 protein insertion into membrane -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26190 BF_2 1992.28 53.46 1846 189240395 XP_967842.2 1994 7.3e-221 PREDICTED: lissencephaly-1 homolog [Tribolium castaneum] 195056833 XM_001995131.1 111 1.63896e-48 Drosophila grimshawi GH22777 (Dgri\GH22777), mRNA K16794 PAFAH1B1, LIS1 platelet-activating factor acetylhydrolase IB subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16794 Q7KNS3 1842 1.3e-204 Lissencephaly-1 homolog OS=Drosophila melanogaster GN=Lis-1 PE=1 SV=2 PF08513//PF00400//PF04508 LisH//WD domain, G-beta repeat//Viral A-type inclusion protein repeat GO:0016032 viral process GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.26191 BF_2 128.47 1.71 3426 642927012 XP_008195103.1 743 1.6e-75 PREDICTED: RNA polymerase II-associated protein 3 [Tribolium castaneum]>gi|270010040|gb|EFA06488.1| hypothetical protein TcasGA2_TC009385 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6T3 334 1.7e-29 RNA polymerase II-associated protein 3 OS=Homo sapiens GN=RPAP3 PE=1 SV=2 PF13174//PF13181//PF00435//PF05363//PF13176//PF13414//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Spectrin repeat//Herpesvirus US12 family//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019049 evasion or tolerance of host defenses by virus GO:0005515 protein binding -- -- KOG4648 Uncharacterized conserved protein, contains LRR repeats Cluster-8309.26195 BF_2 471.00 19.28 1309 189234542 XP_973179.2 994 4.7e-105 PREDICTED: ubiquitin-like protein 7 [Tribolium castaneum]>gi|270001695|gb|EEZ98142.1| hypothetical protein TcasGA2_TC000567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S82 190 3.3e-13 Ubiquitin-like protein 7 OS=Homo sapiens GN=UBL7 PE=1 SV=2 PF00240//PF14560//PF00920 Ubiquitin family//Ubiquitin-like domain//Dehydratase family GO:0008152 metabolic process GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG0010 Ubiquitin-like protein Cluster-8309.26196 BF_2 43.72 0.81 2539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.26197 BF_2 2059.00 61.01 1699 91095077 XP_972905.1 1653 2.3e-181 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 [Tribolium castaneum]>gi|270014775|gb|EFA11223.1| hypothetical protein TcasGA2_TC005188 [Tribolium castaneum] -- -- -- -- -- K12666 OST1, RPN1 oligosaccharyltransferase complex subunit alpha (ribophorin I) http://www.genome.jp/dbget-bin/www_bget?ko:K12666 Q9GMB0 1030 1.7e-110 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 OS=Sus scrofa GN=RPN1 PE=1 SV=1 PF04597 Ribophorin I GO:0018279//GO:0006486 protein N-linked glycosylation via asparagine//protein glycosylation GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0005783//GO:0008250//GO:0016021 endoplasmic reticulum//oligosaccharyltransferase complex//integral component of membrane KOG2291 Oligosaccharyltransferase, alpha subunit (ribophorin I) Cluster-8309.26198 BF_2 119.44 0.72 7189 546685185 ERL94712.1 386 8.1e-34 hypothetical protein D910_11986, partial [Dendroctonus ponderosae] 642911550 XM_008201248.1 169 3.70496e-80 PREDICTED: Tribolium castaneum forkhead box protein P3-like (LOC103314669), mRNA K09409 FOXP forkhead box protein P http://www.genome.jp/dbget-bin/www_bget?ko:K09409 P58462 274 3.2e-22 Forkhead box protein P1 OS=Mus musculus GN=Foxp1 PE=1 SV=1 PF00250//PF02178//PF02973 Forkhead domain//AT hook motif//Sialidase, N-terminal domain GO:0006355//GO:0005975//GO:0006687 regulation of transcription, DNA-templated//carbohydrate metabolic process//glycosphingolipid metabolic process GO:0043565//GO:0003700//GO:0003677//GO:0004308 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//exo-alpha-sialidase activity GO:0005667 transcription factor complex KOG4385 Predicted forkhead transcription factor Cluster-8309.26200 BF_2 9.35 0.61 931 91078698 XP_971450.1 646 7.5e-65 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 538 1.0e-53 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 -- -- GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.26202 BF_2 76.42 2.28 1688 478258657 ENN78707.1 927 3.5e-97 hypothetical protein YQE_04879, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26206 BF_2 87.00 2.35 1836 546674929 ERL86206.1 678 2.9e-68 hypothetical protein D910_03617 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26207 BF_2 144.75 14.56 703 189239148 XP_001807448.1 460 2.1e-43 PREDICTED: protein doublesex [Tribolium castaneum]>gi|402535157|gb|AFQ62105.1| male-specific doublesex isoform m [Tribolium castaneum] 642928399 XR_511419.1 167 4.4873e-80 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 1.3e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF00751 DM DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.26212 BF_2 198.00 4.79 2016 91080721 XP_975378.1 1456 1.9e-158 PREDICTED: lipase 3 [Tribolium castaneum]>gi|270005867|gb|EFA02315.1| hypothetical protein TcasGA2_TC007981 [Tribolium castaneum] -- -- -- -- -- K14452 LIPF gastric triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14452 P80035 701 2.8e-72 Gastric triacylglycerol lipase OS=Canis familiaris GN=LIPF PE=1 SV=2 PF04083//PF07850//PF01738 Partial alpha/beta-hydrolase lipase region//Renin receptor-like protein//Dienelactone hydrolase family GO:0006629//GO:0016042//GO:0007165 lipid metabolic process//lipid catabolic process//signal transduction GO:0004872//GO:0016787//GO:0016788 receptor activity//hydrolase activity//hydrolase activity, acting on ester bonds GO:0016021 integral component of membrane KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.26213 BF_2 98.54 0.95 4616 478250628 ENN71120.1 3290 0.0e+00 hypothetical protein YQE_12053, partial [Dendroctonus ponderosae]>gi|546679527|gb|ERL89982.1| hypothetical protein D910_07341 [Dendroctonus ponderosae] 542217355 XM_003439025.2 116 6.88487e-51 PREDICTED: Oreochromis niloticus pre-mRNA-processing factor 6-like (LOC100696507), mRNA K12855 PRPF6, PRP6 pre-mRNA-processing factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12855 O94906 2718 8.3e-306 Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 PE=1 SV=1 PF13414//PF01267//PF01115//PF02915//PF13371//PF00515//PF02259//PF05843//PF02099//PF06424//PF13181 TPR repeat//F-actin capping protein alpha subunit//F-actin capping protein, beta subunit//Rubrerythrin//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Suppressor of forked protein (Suf)//Josephin//PRP1 splicing factor, N-terminal//Tetratricopeptide repeat GO:0006397//GO:0051016//GO:0000398//GO:0055114 mRNA processing//barbed-end actin filament capping//mRNA splicing, via spliceosome//oxidation-reduction process GO:0008242//GO:0016491//GO:0005515//GO:0046872 omega peptidase activity//oxidoreductase activity//protein binding//metal ion binding GO:0005634//GO:0008290 nucleus//F-actin capping protein complex KOG0495 HAT repeat protein Cluster-8309.26214 BF_2 1.00 1.32 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26216 BF_2 1569.99 23.49 3083 642920970 XP_974457.2 2338 1.6e-260 PREDICTED: serine palmitoyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K00654 SPT serine palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00654 P97363 1348 4.0e-147 Serine palmitoyltransferase 2 OS=Mus musculus GN=Sptlc2 PE=2 SV=2 PF01212//PF04805//PF00155 Beta-eliminating lyase//E10-like protein conserved region//Aminotransferase class I and II GO:0055114//GO:0006520//GO:0009058 oxidation-reduction process//cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016972//GO:0016829 pyridoxal phosphate binding//thiol oxidase activity//lyase activity -- -- KOG1357 Serine palmitoyltransferase Cluster-8309.26219 BF_2 595.86 12.68 2253 642910317 XP_008200281.1 1312 1.1e-141 PREDICTED: dimethyladenosine transferase 1, mitochondrial [Tribolium castaneum] -- -- -- -- -- K15266 TFB1M dimethyladenosine transferase 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K15266 Q7T0W5 857 2.5e-90 Dimethyladenosine transferase 1, mitochondrial OS=Xenopus laevis GN=tfb1m PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.26220 BF_2 110.02 2.21 2374 642933337 XP_008197372.1 841 4.7e-87 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Tribolium castaneum]>gi|270012581|gb|EFA09029.1| hypothetical protein TcasGA2_TC006740 [Tribolium castaneum] 807039743 XM_004534931.2 43 1.33867e-10 PREDICTED: Ceratitis capitata INO80 complex subunit E (In80e), mRNA K11669 INO80E INO80 complex subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K11669 P61092 293 6.7e-25 E3 ubiquitin-protein ligase SIAH1A OS=Mus musculus GN=Siah1a PE=1 SV=1 PF13639//PF00097//PF03145//PF09726//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//Transmembrane protein//zinc-RING finger domain GO:0044267//GO:0006511//GO:0007275 cellular protein metabolic process//ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0046872//GO:0043169//GO:0008270//GO:0005515 metal ion binding//cation binding//zinc ion binding//protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3002 Zn finger protein Cluster-8309.26221 BF_2 26.85 0.68 1944 91082925 XP_972790.1 599 4.4e-59 PREDICTED: mitochondrial import inner membrane translocase subunit Tim21 [Tribolium castaneum]>gi|270007057|gb|EFA03505.1| hypothetical protein TcasGA2_TC013506 [Tribolium castaneum] -- -- -- -- -- K17796 TIM21 mitochondrial import inner membrane translocase subunit TIM21 http://www.genome.jp/dbget-bin/www_bget?ko:K17796 Q3SZV6 346 3.9e-31 Mitochondrial import inner membrane translocase subunit Tim21 OS=Bos taurus GN=TIMM21 PE=2 SV=1 PF08294 TIM21 GO:0030150 protein import into mitochondrial matrix -- -- GO:0005744 mitochondrial inner membrane presequence translocase complex KOG4836 Uncharacterized conserved protein Cluster-8309.26223 BF_2 972.00 176.82 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26224 BF_2 58.91 0.94 2919 642931178 XP_001810533.2 1458 1.6e-158 PREDICTED: general transcription factor 3C polypeptide 3 [Tribolium castaneum]>gi|270011861|gb|EFA08309.1| hypothetical protein TcasGA2_TC005945 [Tribolium castaneum] -- -- -- -- -- K15201 GTP3C3, TFC4 general transcription factor 3C polypeptide 3 (transcription factor C subunit 4) http://www.genome.jp/dbget-bin/www_bget?ko:K15201 Q9Y5Q9 580 4.3e-58 General transcription factor 3C polypeptide 3 OS=Homo sapiens GN=GTF3C3 PE=1 SV=1 PF08631//PF13181//PF13174//PF16045//PF13374//PF00515//PF13371//PF13414//PF13176 Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat//LisH//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0051321 meiotic cell cycle GO:0005515 protein binding -- -- KOG2076 RNA polymerase III transcription factor TFIIIC Cluster-8309.26226 BF_2 20.08 0.63 1620 91077766 XP_968426.1 1023 2.5e-108 PREDICTED: WD repeat domain phosphoinositide-interacting protein 4 [Tribolium castaneum]>gi|270002238|gb|EEZ98685.1| hypothetical protein TcasGA2_TC001220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCV0 778 2.6e-81 WD repeat domain phosphoinositide-interacting protein 4 OS=Xenopus laevis GN=wdr45 PE=2 SV=1 PF08053 Tryptophanase operon leader peptide GO:0031556//GO:0031554 transcriptional attenuation by ribosome//regulation of DNA-templated transcription, termination -- -- -- -- KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.26228 BF_2 31.65 1.00 1616 291170322 ADD82417.1 229 2.9e-16 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 117 6.61e-52 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26230 BF_2 46.49 0.54 3859 270009970 EFA06418.1 1149 1.5e-122 hypothetical protein TcasGA2_TC009297 [Tribolium castaneum] 642927421 XM_962345.3 269 5.09569e-136 PREDICTED: Tribolium castaneum uncharacterized LOC655783 (LOC655783), mRNA -- -- -- -- -- -- -- -- PF06736 Protein of unknown function (DUF1211) GO:0006813 potassium ion transport GO:0005267 potassium channel activity -- -- -- -- Cluster-8309.26231 BF_2 419.45 16.76 1334 642913025 XP_008201356.1 142 3.0e-06 PREDICTED: RING finger protein 165-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130//PF11789//PF17122//PF00097//PF12678//PF12906//PF17123//PF14634//PF13639//PF03854//PF12861 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger of the MIZ type in Nse subunit//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-variant domain//RING-like zinc finger//zinc-RING finger domain//Ring finger domain//P-11 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0035556//GO:0016567 intracellular signal transduction//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding//RNA binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.26232 BF_2 54.55 2.08 1384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26233 BF_2 9.00 0.49 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26234 BF_2 45.00 4.96 667 328899820 AEB54650.1 916 2.6e-96 ribosomal protein S7 [Procambarus clarkii] -- -- -- -- -- K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 P62083 684 8.6e-71 40S ribosomal protein S7 OS=Rattus norvegicus GN=Rps7 PE=1 SV=1 PF02882//PF01251 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Ribosomal protein S7e GO:0055114//GO:0042254//GO:0006412//GO:0046487//GO:0009396 oxidation-reduction process//ribosome biogenesis//translation//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0003735//GO:0004488//GO:0003824 structural constituent of ribosome//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG3320 40S ribosomal protein S7 Cluster-8309.26238 BF_2 17.00 0.72 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26239 BF_2 6.96 0.60 772 642935715 XP_008198140.1 269 3.2e-21 PREDICTED: beclin 1-associated autophagy-related key regulator [Tribolium castaneum] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26242 BF_2 31.19 0.76 2008 642919747 XP_008192048.1 1894 3.1e-209 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 825 1.2e-86 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 PF02822 Antistasin family -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3620 Uncharacterized conserved protein Cluster-8309.26244 BF_2 410.00 5.68 3308 478253220 ENN73591.1 1325 4.9e-143 hypothetical protein YQE_09838, partial [Dendroctonus ponderosae]>gi|546671454|gb|ERL83761.1| hypothetical protein D910_00981 [Dendroctonus ponderosae]>gi|546674153|gb|ERL85609.1| hypothetical protein D910_03028 [Dendroctonus ponderosae]>gi|546685850|gb|ERL95285.1| hypothetical protein D910_12551 [Dendroctonus ponderosae] -- -- -- -- -- K15281 SLC35D solute carrier family 35 http://www.genome.jp/dbget-bin/www_bget?ko:K15281 Q95YI5 1107 3.8e-119 UDP-sugar transporter UST74c OS=Drosophila melanogaster GN=frc PE=1 SV=2 PF09472 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) GO:0015948//GO:0046656 methanogenesis//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane KOG1444 Nucleotide-sugar transporter VRG4/SQV-7 Cluster-8309.26246 BF_2 171.00 1.95 3950 642916131 XP_008190899.1 1951 1.5e-215 PREDICTED: RNA exonuclease 1 homolog [Tribolium castaneum]>gi|270003711|gb|EFA00159.1| hypothetical protein TcasGA2_TC002980 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q8N1G1 794 9.0e-83 RNA exonuclease 1 homolog OS=Homo sapiens GN=REXO1 PE=1 SV=3 PF03854//PF05656 P-11 zinc finger//Protein of unknown function (DUF805) -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding GO:0016021 integral component of membrane KOG2248 3'-5' exonuclease Cluster-8309.26247 BF_2 269.76 1.74 6771 820805554 AKG92768.1 605 3.1e-59 cropped [Leptinotarsa decemlineata] 462279222 APGK01058391.1 41 4.98238e-09 Dendroctonus ponderosae Seq01058401, whole genome shotgun sequence K09108 TFAP4 transcription factor AP-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09108 Q01664 164 1.7e-09 Transcription factor AP-4 OS=Homo sapiens GN=TFAP4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26248 BF_2 763.68 13.19 2710 642919713 XP_008192033.1 1789 6.3e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.4e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.26251 BF_2 429.84 5.67 3456 189235376 XP_968738.2 1786 1.8e-196 PREDICTED: neutral alpha-glucosidase AB isoform X2 [Tribolium castaneum]>gi|270003604|gb|EFA00052.1| hypothetical protein TcasGA2_TC002860 [Tribolium castaneum] 745752852 XM_002174403.2 36 1.52339e-06 Schizosaccharomyces japonicus yFS275 glucosidase II Gls2 mRNA K12317 GANC neutral alpha-glucosidase C http://www.genome.jp/dbget-bin/www_bget?ko:K12317 Q8BVW0 1574 2.8e-173 Neutral alpha-glucosidase C OS=Mus musculus GN=Ganc PE=2 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.26252 BF_2 20.16 0.62 1648 189241705 XP_967022.2 406 8.9e-37 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q8BHN3 300 7.2e-26 Neutral alpha-glucosidase AB OS=Mus musculus GN=Ganab PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.26253 BF_2 660.86 7.18 4135 478251184 ENN71660.1 1199 2.5e-128 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K14410 ACP2 lysosomal acid phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14410 P11117 621 1.1e-62 Lysosomal acid phosphatase OS=Homo sapiens GN=ACP2 PE=1 SV=3 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.26256 BF_2 156.77 6.75 1259 91083895 XP_974479.1 951 4.3e-100 PREDICTED: ATPase family AAA domain-containing protein 3 [Tribolium castaneum]>gi|270007948|gb|EFA04396.1| hypothetical protein TcasGA2_TC014695 [Tribolium castaneum] -- -- -- -- -- K17681 ATAD3A_B ATPase family AAA domain-containing protein 3A/B http://www.genome.jp/dbget-bin/www_bget?ko:K17681 Q6PAX2 653 6.4e-67 ATPase family AAA domain-containing protein 3-B OS=Xenopus laevis GN=atad3-b PE=2 SV=1 -- -- -- -- GO:0005524//GO:0017111 ATP binding//nucleoside-triphosphatase activity -- -- KOG0742 AAA+-type ATPase Cluster-8309.26258 BF_2 235.90 3.11 3462 642922614 XP_008193249.1 1447 3.7e-157 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26259 BF_2 27.92 0.45 2884 642922614 XP_008193249.1 884 5.8e-92 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2626 BF_2 4.00 0.41 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26261 BF_2 112.36 1.59 3247 642922614 XP_008193249.1 1387 3.1e-150 PREDICTED: uncharacterized protein LOC659172 isoform X1 [Tribolium castaneum]>gi|270007519|gb|EFA03967.1| hypothetical protein TcasGA2_TC014112 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26262 BF_2 29.00 1.45 1121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26264 BF_2 11.99 0.33 1799 270005507 EFA01955.1 223 1.6e-15 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 193 2.0e-13 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF02798 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26266 BF_2 520.07 14.17 1822 91080137 XP_968355.1 2213 2.9e-246 PREDICTED: T-complex protein 1 subunit epsilon [Tribolium castaneum]>gi|270005652|gb|EFA02100.1| hypothetical protein TcasGA2_TC007744 [Tribolium castaneum] 769836104 XM_011649878.1 157 4.34027e-74 PREDICTED: Pogonomyrmex barbatus T-complex protein 1 subunit epsilon (LOC105434223), mRNA K09497 CCT5 T-complex protein 1 subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09497 Q4R6V2 1803 4.1e-200 T-complex protein 1 subunit epsilon OS=Macaca fascicularis GN=CCT5 PE=2 SV=1 PF07546//PF00118 EMI domain//TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005515//GO:0051082//GO:0005524 protein binding//unfolded protein binding//ATP binding GO:0005737 cytoplasm KOG0357 Chaperonin complex component, TCP-1 epsilon subunit (CCT5) Cluster-8309.26270 BF_2 3.03 0.35 646 270004092 EFA00540.1 407 2.7e-37 hypothetical protein TcasGA2_TC003405 [Tribolium castaneum] 827544782 XM_012689556.1 56 2.07908e-18 PREDICTED: Bombyx mori inorganic phosphate co-transporter (LOC100500932), transcript variant X2, mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 326 2.7e-29 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26271 BF_2 287.58 3.85 3410 642929686 XP_008195936.1 1180 3.3e-126 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] 462360465 APGK01029384.1 79 1.87656e-30 Dendroctonus ponderosae Seq01029394, whole genome shotgun sequence K06064 HAIRLESS hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06064 Q02308 257 1.4e-20 Protein hairless OS=Drosophila melanogaster GN=H PE=1 SV=2 PF07706 Aminotransferase ubiquitination site GO:0006536//GO:0009821//GO:0009074//GO:0006571//GO:0000162//GO:0006103//GO:0009094 glutamate metabolic process//alkaloid biosynthetic process//aromatic amino acid family catabolic process//tyrosine biosynthetic process//tryptophan biosynthetic process//2-oxoglutarate metabolic process//L-phenylalanine biosynthetic process GO:0030170//GO:0004838 pyridoxal phosphate binding//L-tyrosine:2-oxoglutarate aminotransferase activity -- -- -- -- Cluster-8309.26273 BF_2 197.39 1.33 6518 642921466 XP_008192880.1 4009 0.0e+00 PREDICTED: transient receptor potential-gamma protein [Tribolium castaneum] 194884299 XM_001976197.1 386 0 Drosophila erecta GG20120 (Dere\GG20120), mRNA K05328 TRPCN transient receptor potential cation channel subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05328 Q9VJJ7 3341 0.0e+00 Transient receptor potential-gamma protein OS=Drosophila melanogaster GN=Trpgamma PE=1 SV=2 PF00520//PF09726//PF04692//PF13606 Ion transport protein//Transmembrane protein//Platelet-derived growth factor, N terminal region//Ankyrin repeat GO:0006811//GO:0055085//GO:0040007//GO:0007165//GO:0008283 ion transport//transmembrane transport//growth//signal transduction//cell proliferation GO:0005216//GO:0008083//GO:0005515 ion channel activity//growth factor activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.26277 BF_2 501.51 7.30 3161 91091700 XP_972740.1 3069 0.0e+00 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 F4HTM3 1598 4.2e-176 Mannosyl-oligosaccharide glucosidase GCS1 OS=Arabidopsis thaliana GN=GCS1 PE=1 SV=1 -- -- GO:0009311 oligosaccharide metabolic process GO:0004573 mannosyl-oligosaccharide glucosidase activity -- -- KOG2161 Glucosidase I Cluster-8309.26280 BF_2 2055.83 17.39 5232 646699278 KDR09984.1 1811 3.4e-199 Ribosomal protein S6 kinase beta-1 [Zootermopsis nevadensis] 645004372 XM_008210703.1 188 7.38108e-91 PREDICTED: Nasonia vitripennis ribosomal protein S6 kinase beta-1-like (LOC100115857), transcript variant X3, mRNA K04688 RPS6KB p70 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04688 P67998 1466 1.4e-160 Ribosomal protein S6 kinase beta-1 OS=Oryctolagus cuniculus GN=RPS6KB1 PE=2 SV=1 PF05180//PF07714//PF00433//PF00069//PF06293 DNL zinc finger//Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0016773//GO:0008270//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//zinc ion binding//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.26282 BF_2 188.37 1.58 5262 665804096 XP_008550173.1 2041 7.4e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 189008483 EU616810.1 323 6.67626e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 3.8e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF02214//PF00060//PF00520//PF01092//PF13374 BTB/POZ domain//Ligand-gated ion channel//Ion transport protein//Ribosomal protein S6e//Tetratricopeptide repeat GO:0007165//GO:0055085//GO:0051260//GO:0007268//GO:0006412//GO:0042254//GO:0006811 signal transduction//transmembrane transport//protein homooligomerization//synaptic transmission//translation//ribosome biogenesis//ion transport GO:0005515//GO:0004970//GO:0005216//GO:0003735 protein binding//ionotropic glutamate receptor activity//ion channel activity//structural constituent of ribosome GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular -- -- Cluster-8309.26283 BF_2 478.93 11.79 1987 642921348 XP_008192831.1 2198 1.7e-244 PREDICTED: uncharacterized protein LOC658985 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G5E8K6 233 5.1e-18 Monocarboxylate transporter 6 OS=Mus musculus GN=Slc16a5 PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26284 BF_2 236.90 3.67 2987 91077436 XP_966791.1 3598 0.0e+00 PREDICTED: WD repeat-containing protein 36 [Tribolium castaneum]>gi|270001624|gb|EEZ98071.1| hypothetical protein TcasGA2_TC000478 [Tribolium castaneum] -- -- -- -- -- K14554 UTP21, WDR36 U3 small nucleolar RNA-associated protein 21 http://www.genome.jp/dbget-bin/www_bget?ko:K14554 Q8NI36 2029 4.2e-226 WD repeat-containing protein 36 OS=Homo sapiens GN=WDR36 PE=1 SV=1 PF00400//PF04192//PF00355 WD domain, G-beta repeat//Utp21 specific WD40 associated putative domain//Rieske [2Fe-2S] domain GO:0006364//GO:0055114 rRNA processing//oxidation-reduction process GO:0051537//GO:0016491//GO:0005515 2 iron, 2 sulfur cluster binding//oxidoreductase activity//protein binding GO:0032040 small-subunit processome KOG1539 WD repeat protein Cluster-8309.26286 BF_2 142.00 5.72 1326 478253141 ENN73512.1 1034 1.1e-109 hypothetical protein YQE_09763, partial [Dendroctonus ponderosae]>gi|546678893|gb|ERL89431.1| hypothetical protein D910_06798 [Dendroctonus ponderosae] -- -- -- -- -- K11152 RDH11 retinol dehydrogenase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11152 Q8TC12 513 1.2e-50 Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1 SV=2 PF13520//PF02882//PF00106//PF03435//PF01370 Amino acid permease//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//short chain dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0003333//GO:0055114//GO:0006865//GO:0008152//GO:0009396//GO:0046487 amino acid transmembrane transport//oxidation-reduction process//amino acid transport//metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process GO:0015171//GO:0003824//GO:0050662//GO:0016491//GO:0004488 amino acid transmembrane transporter activity//catalytic activity//coenzyme binding//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity GO:0016020 membrane -- -- Cluster-8309.26289 BF_2 73.58 6.26 779 270001906 EEZ98353.1 159 1.8e-08 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26290 BF_2 12.00 9.61 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15307 Sperm acrosome-associated protein 7 -- -- -- -- GO:0001669 acrosomal vesicle -- -- Cluster-8309.26291 BF_2 191.73 1.32 6384 642921412 XP_008192854.1 1114 2.8e-118 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.43765e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 791 3.2e-82 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF05648//PF00937 Peroxisomal biogenesis factor 11 (PEX11)//Coronavirus nucleocapsid protein GO:0016559 peroxisome fission -- -- GO:0005779//GO:0019013 integral component of peroxisomal membrane//viral nucleocapsid -- -- Cluster-8309.26292 BF_2 37.81 1.75 1193 642926579 XP_008194928.1 228 2.8e-16 PREDICTED: transcription factor 15 isoform X1 [Tribolium castaneum] 564234777 XM_006274259.1 76 2.99745e-29 PREDICTED: Alligator mississippiensis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q7RTU7 190 3.0e-13 Basic helix-loop-helix transcription factor scleraxis OS=Homo sapiens GN=SCX PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26293 BF_2 351.00 7.11 2352 642927551 XP_008195312.1 585 2.2e-57 PREDICTED: protein HEXIM [Tribolium castaneum]>gi|270009936|gb|EFA06384.1| hypothetical protein TcasGA2_TC009262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0X0C4 192 3.4e-13 Protein HEXIM1 OS=Bos taurus GN=HEXIM1 PE=2 SV=1 PF04799//PF15313//PF01166//PF06156//PF04977//PF06005//PF09798//PF01496 fzo-like conserved region//Hexamethylene bis-acetamide-inducible protein//TSC-22/dip/bun family//Protein of unknown function (DUF972)//Septum formation initiator//Protein of unknown function (DUF904)//DNA damage checkpoint protein//V-type ATPase 116kDa subunit family GO:0015992//GO:0007049//GO:0006355//GO:0006260//GO:0000077//GO:0007050//GO:0045859//GO:0015991//GO:0043093//GO:0000917//GO:0008053//GO:0000122 proton transport//cell cycle//regulation of transcription, DNA-templated//DNA replication//DNA damage checkpoint//cell cycle arrest//regulation of protein kinase activity//ATP hydrolysis coupled proton transport//FtsZ-dependent cytokinesis//barrier septum assembly//mitochondrial fusion//negative regulation of transcription from RNA polymerase II promoter GO:0003924//GO:0003700//GO:0015078//GO:0004861//GO:0017069 GTPase activity//transcription factor activity, sequence-specific DNA binding//hydrogen ion transmembrane transporter activity//cyclin-dependent protein serine/threonine kinase inhibitor activity//snRNA binding GO:0016021//GO:0005737//GO:0005667//GO:0005634//GO:0033179//GO:0005741 integral component of membrane//cytoplasm//transcription factor complex//nucleus//proton-transporting V-type ATPase, V0 domain//mitochondrial outer membrane -- -- Cluster-8309.26295 BF_2 60.00 1.41 2065 642936365 XP_008198409.1 151 4.2e-07 PREDICTED: uncharacterized protein LOC103314354 [Tribolium castaneum]>gi|642936367|ref|XP_008198410.1| PREDICTED: uncharacterized protein LOC103314354 [Tribolium castaneum]>gi|270013126|gb|EFA09574.1| hypothetical protein TcasGA2_TC011688 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26298 BF_2 279.50 1.75 6973 642926768 XP_008195006.1 4299 0.0e+00 PREDICTED: copper-transporting ATPase 1 isoform X2 [Tribolium castaneum] 827557043 XM_012694365.1 41 5.13184e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2570 1.8e-288 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF01529//PF00122//PF05138//PF00403 DHHC palmitoyltransferase//E1-E2 ATPase//Phenylacetic acid catabolic protein//Heavy-metal-associated domain GO:0010124//GO:0030001 phenylacetate catabolic process//metal ion transport GO:0046872//GO:0000166//GO:0008270 metal ion binding//nucleotide binding//zinc ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.26299 BF_2 271.74 3.61 3435 642932705 XP_008196952.1 1577 3.1e-172 PREDICTED: HEAT repeat-containing protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R5R2 919 2.5e-97 HEAT repeat-containing protein 6 OS=Pongo abelii GN=HEATR6 PE=2 SV=1 PF00514//PF01667//PF01106//PF02985 Armadillo/beta-catenin-like repeat//Ribosomal protein S27//NifU-like domain//HEAT repeat GO:0042254//GO:0016226//GO:0006412 ribosome biogenesis//iron-sulfur cluster assembly//translation GO:0051536//GO:0003735//GO:0005506//GO:0005515 iron-sulfur cluster binding//structural constituent of ribosome//iron ion binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.26300 BF_2 8.00 1.24 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26303 BF_2 14.00 0.86 970 229891596 A6NA00.1 885 1.5e-92 RecName: Full=40S ribosomal protein SA [Ornithodoros parkeri]>gi|149287168|gb|ABR23483.1| 40S ribosomal protein SA [Ornithodoros parkeri] -- -- -- -- -- K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 A6NA00 885 6.2e-94 40S ribosomal protein SA OS=Ornithodoros parkeri PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.26304 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08918 PhoQ Sensor GO:0016310//GO:0000160//GO:0018106 phosphorylation//phosphorelay signal transduction system//peptidyl-histidine phosphorylation GO:0005524//GO:0046872//GO:0004673 ATP binding//metal ion binding//protein histidine kinase activity GO:0009365//GO:0016020 protein histidine kinase complex//membrane -- -- Cluster-8309.26306 BF_2 125.12 2.63 2276 642915333 XP_008190576.1 634 4.5e-63 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 473 8.6e-46 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26307 BF_2 109.00 3.15 1735 546681812 ERL91838.1 1796 6.2e-198 hypothetical protein D910_09163 [Dendroctonus ponderosae] -- -- -- -- -- K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1756 1.1e-194 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.26308 BF_2 297.87 5.06 2749 642924494 XP_008194318.1 1947 3.1e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 6.9e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.26310 BF_2 101.47 2.71 1854 91088619 XP_974054.1 1761 7.6e-194 PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [Tribolium castaneum]>gi|270011691|gb|EFA08139.1| hypothetical protein TcasGA2_TC005756 [Tribolium castaneum] -- -- -- -- -- K00995 pgsA, PGS1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00995 Q32NB8 953 1.5e-101 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Homo sapiens GN=PGS1 PE=2 SV=1 PF00614 Phospholipase D Active site motif GO:0008654 phospholipid biosynthetic process GO:0003824//GO:0016780 catalytic activity//phosphotransferase activity, for other substituted phosphate groups -- -- KOG3964 Phosphatidylglycerolphosphate synthase Cluster-8309.26312 BF_2 1.00 4.65 255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26317 BF_2 23.00 2.73 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02975 Methylamine dehydrogenase, L chain GO:0055114//GO:0009308 oxidation-reduction process//amine metabolic process GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0042597 periplasmic space -- -- Cluster-8309.26318 BF_2 259.00 3.45 3432 478254021 ENN74313.1 3107 0.0e+00 hypothetical protein YQE_09284, partial [Dendroctonus ponderosae] 642910778 XM_008195184.1 354 0 PREDICTED: Tribolium castaneum membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (LOC657569), mRNA K05629 AIP1 atrophin-1 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05629 O88382 888 9.8e-94 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Magi2 PE=1 SV=1 PF01165//PF00595//PF07782//PF13180//PF00397 Ribosomal protein S21//PDZ domain (Also known as DHR or GLGF)//DC-STAMP-like protein//PDZ domain//WW domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0016021//GO:0005840 integral component of membrane//ribosome KOG3209 WW domain-containing protein Cluster-8309.26319 BF_2 67.00 1.34 2385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26320 BF_2 102.86 1.11 4175 642937253 XP_008198758.1 2387 4.4e-266 PREDICTED: probable ATP-dependent RNA helicase YTHDC2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6S0 1644 2.6e-181 Probable ATP-dependent RNA helicase YTHDC2 OS=Homo sapiens GN=YTHDC2 PE=1 SV=2 PF04408//PF02562//PF00023//PF01424//PF00437//PF02386//PF00270 Helicase associated domain (HA2)//PhoH-like protein//Ankyrin repeat//R3H domain//Type II/IV secretion system protein//Cation transport protein//DEAD/DEAH box helicase GO:0006810//GO:0055085//GO:0006812 transport//transmembrane transport//cation transport GO:0005515//GO:0005524//GO:0004386//GO:0008324//GO:0003676 protein binding//ATP binding//helicase activity//cation transmembrane transporter activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.26321 BF_2 515.09 4.16 5470 642937251 XP_008198757.1 2387 5.8e-266 PREDICTED: probable ATP-dependent RNA helicase YTHDC2 isoform X1 [Tribolium castaneum]>gi|270001262|gb|EEZ97709.1| benign gonial cell neoplasm [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6S0 1644 3.4e-181 Probable ATP-dependent RNA helicase YTHDC2 OS=Homo sapiens GN=YTHDC2 PE=1 SV=2 PF00437//PF00270//PF02386//PF00023//PF01424//PF02562//PF04408 Type II/IV secretion system protein//DEAD/DEAH box helicase//Cation transport protein//Ankyrin repeat//R3H domain//PhoH-like protein//Helicase associated domain (HA2) GO:0055085//GO:0006810//GO:0006812 transmembrane transport//transport//cation transport GO:0005524//GO:0004386//GO:0016787//GO:0005515//GO:0008324//GO:0097159//GO:0003676//GO:1901363 ATP binding//helicase activity//hydrolase activity//protein binding//cation transmembrane transporter activity//organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.26325 BF_2 141.00 8.56 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26327 BF_2 20.00 0.97 1150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26330 BF_2 14.71 0.33 2136 332376807 AEE63543.1 981 2.4e-103 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 691 4.3e-71 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF01053//PF00155 Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.26331 BF_2 22.65 0.76 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26334 BF_2 175.00 2.49 3225 820805516 AKG92749.1 2092 5.5e-232 clock [Leptinotarsa decemlineata] 805825616 XM_012297303.1 135 1.31414e-61 PREDICTED: Megachile rotundata circadian locomoter output cycles protein kaput (LOC100878984), transcript variant X3, mRNA K02223 CLOCK, KAT13D circadian locomoter output cycles kaput protein http://www.genome.jp/dbget-bin/www_bget?ko:K02223 O61735 1157 5.9e-125 Circadian locomoter output cycles protein kaput OS=Drosophila melanogaster GN=Clk PE=1 SV=3 PF08447//PF00010//PF00989//PF00523 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold//Fusion glycoprotein F0 GO:0006355//GO:0006948 regulation of transcription, DNA-templated//induction by virus of host cell-cell fusion GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.26336 BF_2 317.32 5.59 2662 642921119 XP_975344.2 2182 1.7e-242 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum]>gi|270006197|gb|EFA02645.1| hypothetical protein TcasGA2_TC008366 [Tribolium castaneum] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q0VD19 1129 8.7e-122 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.26339 BF_2 478.17 5.55 3894 91081997 XP_969187.1 2758 3.9e-309 PREDICTED: pre-mRNA 3' end processing protein WDR33 [Tribolium castaneum]>gi|270007376|gb|EFA03824.1| hypothetical protein TcasGA2_TC013939 [Tribolium castaneum] 556962117 XM_005991191.1 147 3.39303e-68 PREDICTED: Latimeria chalumnae WD repeat domain 33 (WDR33), mRNA K15542 PFS2 polyadenylation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15542 Q8K4P0 1664 1.2e-183 pre-mRNA 3' end processing protein WDR33 OS=Mus musculus GN=Wdr33 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0284 Polyadenylation factor I complex, subunit PFS2 Cluster-8309.26340 BF_2 6.75 0.49 866 817072391 XP_012258295.1 1284 7.3e-139 PREDICTED: tubulin alpha-1 chain-like [Athalia rosae] 195498861 XM_002096671.1 477 0 Drosophila yakuba alphaTub84B (Dyak\alphaTub84B), partial mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P06603 1290 6.0e-141 Tubulin alpha-1 chain OS=Drosophila melanogaster GN=alphaTub84B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1376 Alpha tubulin Cluster-8309.26342 BF_2 440.63 5.32 3752 642931340 XP_008196537.1 2722 5.7e-305 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X2 [Tribolium castaneum] 645002817 XM_008209793.1 317 1.02759e-162 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 2212 3.2e-247 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.26344 BF_2 6.68 0.57 777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26345 BF_2 137.49 1.35 4548 642925191 XP_008194463.1 3204 0.0e+00 PREDICTED: myelin regulatory factor isoform X4 [Tribolium castaneum]>gi|270008766|gb|EFA05214.1| hypothetical protein TcasGA2_TC015354 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.20062e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1228 4.9e-133 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF05224//PF10152 NDT80 / PhoG like DNA-binding family//Predicted coiled-coil domain-containing protein (DUF2360) -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.26346 BF_2 225.94 2.19 4602 642925191 XP_008194463.1 3144 0.0e+00 PREDICTED: myelin regulatory factor isoform X4 [Tribolium castaneum]>gi|270008766|gb|EFA05214.1| hypothetical protein TcasGA2_TC015354 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.23893e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1205 2.3e-130 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF10152//PF05224 Predicted coiled-coil domain-containing protein (DUF2360)//NDT80 / PhoG like DNA-binding family -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.26347 BF_2 6.00 0.89 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26348 BF_2 730.32 13.88 2489 91092950 XP_972452.1 3109 0.0e+00 PREDICTED: probable glutamine--tRNA ligase [Tribolium castaneum]>gi|270003024|gb|EEZ99471.1| hypothetical protein TcasGA2_TC000042 [Tribolium castaneum] 815821208 XM_012376424.1 182 7.54819e-88 PREDICTED: Linepithema humile probable glutamine--tRNA ligase (LOC105677665), mRNA K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 2657 5.3e-299 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF04558//PF04557//PF00749//PF03950 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetases class I (E and Q), anti-codon binding domain GO:0006425//GO:0043039//GO:0006418 glutaminyl-tRNA aminoacylation//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005524//GO:0016876//GO:0004812//GO:0000166//GO:0004819 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity//nucleotide binding//glutamine-tRNA ligase activity GO:0005737 cytoplasm KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.26350 BF_2 188.00 10.72 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26351 BF_2 207.22 2.88 3295 642930462 XP_008196413.1 2488 6.8e-278 PREDICTED: phosphofurin acidic cluster sorting protein 1 [Tribolium castaneum]>gi|270009398|gb|EFA05846.1| hypothetical protein TcasGA2_TC008635 [Tribolium castaneum] 558214452 XM_006108296.1 57 3.07633e-18 PREDICTED: Myotis lucifugus phosphofurin acidic cluster sorting protein 2 (PACS2), partial mRNA -- -- -- -- Q6VY07 416 5.1e-39 Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens GN=PACS1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3709 PACS-1 cytosolic sorting protein Cluster-8309.26352 BF_2 105.00 2.56 2004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26353 BF_2 147.14 1.33 4906 642915162 XP_008190500.1 1220 1.1e-130 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07283 146 1.5e-07 Trichohyalin OS=Homo sapiens GN=TCHH PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26354 BF_2 40.69 0.47 3901 642927147 XP_008195157.1 3612 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 425 5.5e-40 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.26357 BF_2 26.01 0.32 3650 642936562 XP_008198486.1 1449 2.3e-157 PREDICTED: somatostatin receptor type 2 isoform X1 [Tribolium castaneum] 462360042 APGK01029530.1 119 1.16769e-52 Dendroctonus ponderosae Seq01029540, whole genome shotgun sequence K04218 SSTR2 somatostatin receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04218 P30874 580 5.4e-58 Somatostatin receptor type 2 OS=Homo sapiens GN=SSTR2 PE=1 SV=1 PF00001//PF13994 7 transmembrane receptor (rhodopsin family)//PgaD-like protein GO:0007186//GO:0042710 G-protein coupled receptor signaling pathway//biofilm formation GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.26358 BF_2 8.49 2.76 415 241238985 XP_002401441.1 205 4.6e-14 52 kD repressor of inhibitor of protein kinase, putative [Ixodes scapularis]>gi|215496163|gb|EEC05804.1| 52 kD repressor of inhibitor of protein kinase, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- O43422 189 1.3e-13 52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens GN=PRKRIR PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.26359 BF_2 11.95 0.41 1518 642937480 XP_008198856.1 184 4.5e-11 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26360 BF_2 2.00 0.39 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26361 BF_2 161.29 8.02 1128 270015869 EFA12317.1 327 8.8e-28 hypothetical protein TcasGA2_TC004218 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01184 GPR1/FUN34/yaaH family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.26362 BF_2 28.52 0.87 1653 478251391 ENN71857.1 312 7.1e-26 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 P54726 202 1.7e-14 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 PF09280//PF00995 XPC-binding domain//Sec1 family GO:0006289//GO:0006904//GO:0016192//GO:0006281//GO:0043161 nucleotide-excision repair//vesicle docking involved in exocytosis//vesicle-mediated transport//DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.26363 BF_2 216.98 5.89 1829 91087253 XP_975524.1 1311 1.1e-141 PREDICTED: uncharacterized protein LOC664424 [Tribolium castaneum]>gi|270009552|gb|EFA06000.1| hypothetical protein TcasGA2_TC008826 [Tribolium castaneum] 820857889 XM_012490556.1 37 2.22253e-07 PREDICTED: Apis florea uncharacterized LOC100871900 (LOC100871900), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26366 BF_2 2.00 0.77 395 861594808 KMQ83108.1 340 9.6e-30 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26367 BF_2 2.00 2.98 298 795023964 XP_011861119.1 137 2.5e-06 PREDICTED: uncharacterized protein LOC105558173 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26368 BF_2 5.00 0.99 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2637 BF_2 3.17 0.50 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26370 BF_2 11.00 0.42 1377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26371 BF_2 98.45 1.12 3965 642910771 XP_008193403.1 2225 2.6e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.0e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00620//PF10297//PF00150 RhoGAP domain//Minimal binding motif of Hap4 for binding to Hap2/3/5//Cellulase (glycosyl hydrolase family 5) GO:0006355//GO:0007165//GO:0005975 regulation of transcription, DNA-templated//signal transduction//carbohydrate metabolic process GO:0004553//GO:0003677 hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.26372 BF_2 532.91 3.53 6594 91086487 XP_970606.1 1037 2.4e-109 PREDICTED: putative Rab-43-like protein ENSP00000330714 [Tribolium castaneum]>gi|270009806|gb|EFA06254.1| hypothetical protein TcasGA2_TC009113 [Tribolium castaneum] -- -- -- -- -- K07930 RAB43 Ras-related protein Rab-43 http://www.genome.jp/dbget-bin/www_bget?ko:K07930 Q86YS6 619 2.9e-62 Ras-related protein Rab-43 OS=Homo sapiens GN=RAB43 PE=1 SV=1 PF00096//PF00025//PF14991//PF08477//PF08513//PF01926//PF08710//PF00071//PF10662//PF04670//PF02367 Zinc finger, C2H2 type//ADP-ribosylation factor family//Protein melan-A//Ras of Complex, Roc, domain of DAPkinase//LisH//50S ribosome-binding GTPase//nsp9 replicase//Ras family//Ethanolamine utilisation - propanediol utilisation//Gtr1/RagA G protein conserved region//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0019079//GO:0006576//GO:0007264//GO:0015031//GO:0002949 viral genome replication//cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport//tRNA threonylcarbamoyladenosine modification GO:0005515//GO:0003723//GO:0005524//GO:0046872//GO:0005525 protein binding//RNA binding//ATP binding//metal ion binding//GTP binding GO:0042470 melanosome KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.26376 BF_2 132.40 2.67 2358 478255293 ENN75519.1 1952 6.9e-216 hypothetical protein YQE_07863, partial [Dendroctonus ponderosae]>gi|546683153|gb|ERL93004.1| hypothetical protein D910_10306 [Dendroctonus ponderosae] 572269069 XM_006612496.1 54 1.02053e-16 PREDICTED: Apis dorsata PAB-dependent poly(A)-specific ribonuclease subunit 3-like (LOC102671478), mRNA K12572 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12572 Q95RR8 1315 2.1e-143 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Drosophila melanogaster GN=CG11486 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3741 Poly(A) ribonuclease subunit Cluster-8309.26377 BF_2 294.89 6.13 2301 478255293 ENN75519.1 1952 6.7e-216 hypothetical protein YQE_07863, partial [Dendroctonus ponderosae]>gi|546683153|gb|ERL93004.1| hypothetical protein D910_10306 [Dendroctonus ponderosae] 572269069 XM_006612496.1 54 9.95489e-17 PREDICTED: Apis dorsata PAB-dependent poly(A)-specific ribonuclease subunit 3-like (LOC102671478), mRNA K12572 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12572 Q95RR8 1315 2.0e-143 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Drosophila melanogaster GN=CG11486 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3741 Poly(A) ribonuclease subunit Cluster-8309.26378 BF_2 540.00 34.39 944 91088997 XP_967529.1 296 2.9e-24 PREDICTED: cytochrome c oxidase copper chaperone [Tribolium castaneum]>gi|642932591|ref|XP_008196914.1| PREDICTED: cytochrome c oxidase copper chaperone [Tribolium castaneum]>gi|270012381|gb|EFA08829.1| hypothetical protein TcasGA2_TC006526 [Tribolium castaneum] -- -- -- -- -- K02260 COX17 cytochrome c oxidase assembly protein subunit 17 http://www.genome.jp/dbget-bin/www_bget?ko:K02260 Q6J3Q7 218 1.3e-16 Cytochrome c oxidase copper chaperone OS=Canis familiaris GN=COX17 PE=3 SV=3 PF00693//PF11095//PF05051 Thymidine kinase from herpesvirus//Gem-associated protein 7 (Gemin7)//Cytochrome C oxidase copper chaperone (COX17) GO:0006230//GO:0006825//GO:0006206 TMP biosynthetic process//copper ion transport//pyrimidine nucleobase metabolic process GO:0004797//GO:0005507//GO:0016531//GO:0005524 thymidine kinase activity//copper ion binding//copper chaperone activity//ATP binding GO:0032797//GO:0005758 SMN complex//mitochondrial intermembrane space KOG3496 Cytochrome c oxidase assembly protein/Cu2+ chaperone COX17 Cluster-8309.26381 BF_2 905.00 5.35 7369 189237589 XP_975112.2 10593 0.0e+00 PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|642923840|ref|XP_008193901.1| PREDICTED: myosin-VIIa [Tribolium castaneum]>gi|270006913|gb|EFA03361.1| hypothetical protein TcasGA2_TC013346 [Tribolium castaneum] 642923841 XM_970019.3 1900 0 PREDICTED: Tribolium castaneum myosin 7A (LOC663995), transcript variant X2, mRNA K10359 MYO7 myosin VII http://www.genome.jp/dbget-bin/www_bget?ko:K10359 Q17LW0 9910 0.0e+00 Myosin-VIIa OS=Aedes aegypti GN=ck PE=3 SV=1 PF00788//PF00640//PF02367//PF00018//PF00005//PF00784//PF00063//PF00612 Ras association (RalGDS/AF-6) domain//Phosphotyrosine interaction domain (PTB/PID)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//SH3 domain//ABC transporter//MyTH4 domain//Myosin head (motor domain)//IQ calmodulin-binding motif GO:0007165//GO:0002949 signal transduction//tRNA threonylcarbamoyladenosine modification GO:0005515//GO:0005524//GO:0016887//GO:0003774 protein binding//ATP binding//ATPase activity//motor activity GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.26383 BF_2 41.95 0.80 2480 91076548 XP_966358.1 499 2.2e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.7e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF05093 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226 iron-sulfur cluster assembly GO:0051536 iron-sulfur cluster binding GO:0005737 cytoplasm KOG4020 Protein DRE2, required for cell viability Cluster-8309.26384 BF_2 554.46 5.23 4724 478251184 ENN71660.1 1199 2.9e-128 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K02330 POLB DNA polymerase beta http://www.genome.jp/dbget-bin/www_bget?ko:K02330 O57383 972 2.5e-103 DNA polymerase beta OS=Xenopus laevis GN=polb PE=1 SV=3 PF00328//PF10391//PF00633//PF01367//PF01909 Histidine phosphatase superfamily (branch 2)//Fingers domain of DNA polymerase lambda//Helix-hairpin-helix motif//5'-3' exonuclease, C-terminal SAM fold//Nucleotidyltransferase domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0016779//GO:0003993//GO:0034061//GO:0003824//GO:0003677 nucleotidyltransferase activity//acid phosphatase activity//DNA polymerase activity//catalytic activity//DNA binding GO:0005634 nucleus -- -- Cluster-8309.26386 BF_2 463.19 6.33 3349 478257725 ENN77868.1 1833 6.2e-202 hypothetical protein YQE_05546, partial [Dendroctonus ponderosae]>gi|546677692|gb|ERL88486.1| hypothetical protein D910_05872 [Dendroctonus ponderosae] -- -- -- -- -- K13578 BMPR1B, ALK6 bone morphogenetic protein receptor type-1B http://www.genome.jp/dbget-bin/www_bget?ko:K13578 O00238 1361 1.4e-148 Bone morphogenetic protein receptor type-1B OS=Homo sapiens GN=BMPR1B PE=1 SV=1 PF08515//PF01064//PF15048//PF08091//PF06293//PF00069//PF07714 Transforming growth factor beta type I GS-motif//Activin types I and II receptor domain//Organic solute transporter subunit beta protein//Spider insecticidal peptide//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468//GO:0015721//GO:0006810//GO:0007178//GO:0009405 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//bile acid and bile salt transport//transport//transmembrane receptor protein serine/threonine kinase signaling pathway//pathogenesis GO:0004672//GO:0016773//GO:0004675//GO:0005215//GO:0046982//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein serine/threonine kinase activity//transporter activity//protein heterodimerization activity//ATP binding GO:0005576//GO:0016020//GO:0005886 extracellular region//membrane//plasma membrane -- -- Cluster-8309.26387 BF_2 484.52 7.61 2952 91088837 XP_970678.1 1873 1.2e-206 PREDICTED: bone morphogenetic protein receptor type-1B isoform X1 [Tribolium castaneum] -- -- -- -- -- K13578 BMPR1B, ALK6 bone morphogenetic protein receptor type-1B http://www.genome.jp/dbget-bin/www_bget?ko:K13578 O00238 1358 2.7e-148 Bone morphogenetic protein receptor type-1B OS=Homo sapiens GN=BMPR1B PE=1 SV=1 PF07714//PF08091//PF00069//PF06293//PF15048//PF01064//PF08515 Protein tyrosine kinase//Spider insecticidal peptide//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Organic solute transporter subunit beta protein//Activin types I and II receptor domain//Transforming growth factor beta type I GS-motif GO:0016310//GO:0009405//GO:0007178//GO:0006810//GO:0015721//GO:0006468//GO:0009069 phosphorylation//pathogenesis//transmembrane receptor protein serine/threonine kinase signaling pathway//transport//bile acid and bile salt transport//protein phosphorylation//serine family amino acid metabolic process GO:0046982//GO:0005215//GO:0004675//GO:0016773//GO:0004672//GO:0005524 protein heterodimerization activity//transporter activity//transmembrane receptor protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding GO:0005886//GO:0016020//GO:0005576 plasma membrane//membrane//extracellular region -- -- Cluster-8309.26388 BF_2 14.00 0.35 1958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00837 Iodothyronine deiodinase GO:0055114 oxidation-reduction process GO:0004800 thyroxine 5'-deiodinase activity -- -- -- -- Cluster-8309.26389 BF_2 113.49 1.73 3028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.26395 BF_2 862.88 5.63 6695 270014943 EFA11391.1 6889 0.0e+00 hypothetical protein TcasGA2_TC011551 [Tribolium castaneum] 642910356 XM_008202069.1 1139 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Genghis Khan (LOC660018), mRNA K16307 CDC42BP serine/threonine-protein kinase MRCK http://www.genome.jp/dbget-bin/www_bget?ko:K16307 Q9W1B0 2612 2.4e-293 Serine/threonine-protein kinase Genghis Khan OS=Drosophila melanogaster GN=gek PE=1 SV=1 PF07714//PF00433//PF00069//PF08826//PF00130//PF01291 Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//DMPK coiled coil domain like//Phorbol esters/diacylglycerol binding domain (C1 domain)//LIF / OSM family GO:0007165//GO:0009069//GO:0006468//GO:0016310//GO:0006955//GO:0035556 signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation//immune response//intracellular signal transduction GO:0005524//GO:0005125//GO:0004672//GO:0004674 ATP binding//cytokine activity//protein kinase activity//protein serine/threonine kinase activity GO:0005576 extracellular region KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.26396 BF_2 67.67 0.83 3692 642928441 XP_008193786.1 222 4.3e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26399 BF_2 107.73 0.86 5528 642934848 XP_008197836.1 2701 2.3e-302 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.72866e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA K10423 CLIP3_4 CAP-Gly domain-containing linker protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10423 Q5JR59 251 1.2e-19 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26400 BF_2 66.79 0.91 3372 91085925 XP_969990.1 570 1.8e-55 PREDICTED: charged multivesicular body protein 4b [Tribolium castaneum]>gi|270009953|gb|EFA06401.1| hypothetical protein TcasGA2_TC009279 [Tribolium castaneum] 827540193 XM_004923412.2 101 1.09323e-42 PREDICTED: Bombyx mori charged multivesicular body protein 4b (LOC101737568), mRNA K12194 CHMP4, SNF7, VPS32 charged multivesicular body protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12194 Q6IQ73 457 9.2e-44 Charged multivesicular body protein 4c OS=Danio rerio GN=chmp4c PE=2 SV=1 PF00293//PF02993//PF08707//PF03357//PF04053//PF02347 NUDIX domain//Minor capsid protein VI//Primase C terminal 2 (PriCT-2)//Snf7//Coatomer WD associated region//Glycine cleavage system P-protein GO:0006886//GO:0016192//GO:0006563//GO:0006544//GO:0055114//GO:0006546//GO:0007034//GO:0006566 intracellular protein transport//vesicle-mediated transport//L-serine metabolic process//glycine metabolic process//oxidation-reduction process//glycine catabolic process//vacuolar transport//threonine metabolic process GO:0005198//GO:0016787//GO:0016817//GO:0004375 structural molecule activity//hydrolase activity//hydrolase activity, acting on acid anhydrides//glycine dehydrogenase (decarboxylating) activity GO:0019028//GO:0030117 viral capsid//membrane coat KOG1656 Protein involved in glucose derepression and pre-vacuolar endosome protein sorting Cluster-8309.26402 BF_2 12.00 5.40 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26403 BF_2 15.53 0.61 1354 642918274 XP_008191440.1 1070 7.4e-114 PREDICTED: purine nucleoside phosphorylase isoform X1 [Tribolium castaneum] 327297537 XM_003233415.1 34 7.60256e-06 Trichophyton rubrum CBS 118892 purine nucleoside phosphorylase (TERG_06452) mRNA, complete cds K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P55859 754 1.3e-78 Purine nucleoside phosphorylase OS=Bos taurus GN=PNP PE=1 SV=3 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.26404 BF_2 146.00 1.32 4917 646707954 KDR14467.1 1794 3.0e-197 Beta-1-syntrophin [Zootermopsis nevadensis] 742230363 XM_010902633.1 54 2.14363e-16 PREDICTED: Esox lucius syntrophin, alpha 1 (snta1), transcript variant X2, mRNA -- -- -- -- Q13884 1059 2.1e-113 Beta-1-syntrophin OS=Homo sapiens GN=SNTB1 PE=1 SV=3 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3551 Syntrophins (type beta) Cluster-8309.26405 BF_2 25.35 0.96 1390 478257982 ENN78120.1 192 4.9e-12 hypothetical protein YQE_05274, partial [Dendroctonus ponderosae]>gi|546682483|gb|ERL92406.1| hypothetical protein D910_09720 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14991 Protein melan-A -- -- -- -- GO:0042470 melanosome -- -- Cluster-8309.26406 BF_2 15.78 0.34 2243 270009832 EFA06280.1 2878 0.0e+00 hypothetical protein TcasGA2_TC009146 [Tribolium castaneum] 686484113 KM036513.1 190 2.42545e-92 Locusta migratoria Mcm5 mRNA, complete cds K02209 MCM5, CDC46 DNA replication licensing factor MCM5 http://www.genome.jp/dbget-bin/www_bget?ko:K02209 Q9VGW6 2630 6.5e-296 DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 PF07728//PF07726//PF00158//PF00493 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//MCM2/3/5 family GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0005524//GO:0003677//GO:0016887//GO:0008134 ATP binding//DNA binding//ATPase activity//transcription factor binding GO:0005667 transcription factor complex KOG0481 DNA replication licensing factor, MCM5 component Cluster-8309.26409 BF_2 11.41 1.82 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26411 BF_2 141.00 7.41 1083 91080835 XP_970786.1 1073 2.7e-114 PREDICTED: vacuolar-sorting protein SNF8 [Tribolium castaneum]>gi|642919734|ref|XP_008192042.1| PREDICTED: vacuolar-sorting protein SNF8 [Tribolium castaneum]>gi|270005419|gb|EFA01867.1| hypothetical protein TcasGA2_TC007472 [Tribolium castaneum] 820834273 XM_012495487.1 105 2.05563e-45 PREDICTED: Apis florea vacuolar-sorting protein SNF8 (LOC100864896), transcript variant X1, mRNA K12188 SNF8, EAP30 ESCRT-II complex subunit VPS22 http://www.genome.jp/dbget-bin/www_bget?ko:K12188 Q9CZ28 770 1.5e-80 Vacuolar-sorting protein SNF8 OS=Mus musculus GN=Snf8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3341 RNA polymerase II transcription factor complex subunit Cluster-8309.26412 BF_2 45.00 0.92 2336 805784346 XP_012140054.1 665 1.2e-66 PREDICTED: DNA primase large subunit-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q84WJ2 335 8.9e-30 Probable DNA primase large subunit OS=Arabidopsis thaliana GN=At1g67320 PE=2 SV=2 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.26414 BF_2 27.76 0.67 2021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.26415 BF_2 296.94 12.42 1287 332374970 AEE62626.1 877 1.7e-91 unknown [Dendroctonus ponderosae] 826311409 XM_012650547.1 81 5.38472e-32 PREDICTED: Propithecus coquereli anti-silencing function 1A histone chaperone (ASF1A), mRNA K10753 ASF1 histone chaperone ASF1 http://www.genome.jp/dbget-bin/www_bget?ko:K10753 Q9V464 699 3.0e-72 Histone chaperone asf1 OS=Drosophila melanogaster GN=asf1 PE=1 SV=1 PF04729 ASF1 like histone chaperone GO:0006333 chromatin assembly or disassembly -- -- GO:0005634 nucleus KOG3265 Histone chaperone involved in gene silencing Cluster-8309.26417 BF_2 132.73 1.39 4292 546677720 ERL88511.1 1320 2.4e-142 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 3.98913e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 977 5.9e-104 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.26418 BF_2 48.33 0.50 4358 546677720 ERL88511.1 1304 1.8e-140 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 4.05099e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 964 1.9e-102 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.26419 BF_2 129.91 3.04 2075 546677720 ERL88511.1 930 1.9e-97 hypothetical protein D910_05897 [Dendroctonus ponderosae] 779993624 XM_011673730.1 66 1.91268e-23 PREDICTED: Strongylocentrotus purpuratus phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (LOC580595), mRNA K00920 PIP4K2 1-phosphatidylinositol-5-phosphate 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00920 P48426 571 3.4e-57 Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha OS=Homo sapiens GN=PIP4K2A PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.26421 BF_2 269.00 7.02 1889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26422 BF_2 580.65 11.72 2360 478256027 ENN76226.1 1030 5.6e-109 hypothetical protein YQE_07193, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26423 BF_2 11.04 0.80 862 270003399 EEZ99846.1 252 3.4e-19 hypothetical protein TcasGA2_TC002628 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 166 1.3e-10 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.26425 BF_2 275.52 2.46 4967 270007830 EFA04278.1 3072 0.0e+00 hypothetical protein TcasGA2_TC014568 [Tribolium castaneum] 642924109 XM_008195787.1 569 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1466 1.4e-160 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF07714//PF00069//PF06293//PF07463 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//NUMOD4 motif GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0016788//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//hydrolase activity, acting on ester bonds//protein kinase activity GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.26426 BF_2 29.23 0.34 3880 270010719 EFA07167.1 1207 2.8e-129 hypothetical protein TcasGA2_TC010166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U584 455 1.8e-43 SH3 domain-binding protein 5-like OS=Xenopus laevis GN=sh3bp5l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.26430 BF_2 104.23 1.06 4384 642918597 XP_008197482.1 3546 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 4B-like [Tribolium castaneum] 642918596 XM_008199260.1 294 7.33947e-150 PREDICTED: Tribolium castaneum pleckstrin homology domain-containing family G member 4B-like (LOC656506), mRNA -- -- -- -- Q58EX7 915 9.3e-97 Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1 PF00739//PF00621 Trans-activation protein X//RhoGEF domain GO:0019079//GO:0035023//GO:0043087 viral genome replication//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.26431 BF_2 223.50 2.29 4372 642918597 XP_008197482.1 3555 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 4B-like [Tribolium castaneum] 642918596 XM_008199260.1 294 7.31921e-150 PREDICTED: Tribolium castaneum pleckstrin homology domain-containing family G member 4B-like (LOC656506), mRNA -- -- -- -- Q58EX7 915 9.3e-97 Puratrophin-1 OS=Homo sapiens GN=PLEKHG4 PE=1 SV=1 PF00745//PF00739//PF00621 Glutamyl-tRNAGlu reductase, dimerisation domain//Trans-activation protein X//RhoGEF domain GO:0035023//GO:0019079//GO:0033014//GO:0043087//GO:0055114 regulation of Rho protein signal transduction//viral genome replication//tetrapyrrole biosynthetic process//regulation of GTPase activity//oxidation-reduction process GO:0008883//GO:0050661//GO:0005089 glutamyl-tRNA reductase activity//NADP binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.26435 BF_2 559.60 43.04 831 91088191 XP_972764.1 470 1.7e-44 PREDICTED: ribonuclease UK114 [Tribolium castaneum]>gi|270012137|gb|EFA08585.1| hypothetical protein TcasGA2_TC006240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52758 383 8.6e-36 Ribonuclease UK114 OS=Homo sapiens GN=HRSP12 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2317 Putative translation initiation inhibitor UK114/IBM1 Cluster-8309.26440 BF_2 10.47 0.71 908 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03975 CheD chemotactic sensory transduction GO:0006935//GO:0006807 chemotaxis//nitrogen compound metabolic process GO:0050568 protein-glutamine glutaminase activity -- -- -- -- Cluster-8309.26441 BF_2 12.89 0.51 1339 478250947 ENN71431.1 845 9.0e-88 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] 642939405 XM_008195063.1 207 5.07952e-102 PREDICTED: Tribolium castaneum uncharacterized LOC661130 (LOC661130), mRNA -- -- -- -- Q61830 178 8.2e-12 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26446 BF_2 7.00 0.36 1098 642938300 XP_008192786.1 431 7.5e-40 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X1 [Tribolium castaneum]>gi|642938302|ref|XP_008192794.1| PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X1 [Tribolium castaneum] 642938313 XM_008194605.1 195 1.94261e-95 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X8, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26447 BF_2 912.10 9.16 4453 478252002 ENN72437.1 1467 2.3e-159 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 158 2.98185e-74 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 1027 9.7e-110 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF16588//PF00275//PF13014//PF00098//PF08273//PF03604//PF00013 C2H2 zinc-finger//EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)//KH domain//Zinc knuckle//Zinc-binding domain of primase-helicase//DNA directed RNA polymerase, 7 kDa subunit//KH domain GO:0006144//GO:0006351//GO:0006206//GO:0006269 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//DNA replication, synthesis of RNA primer GO:0003896//GO:0003677//GO:0003723//GO:0004386//GO:0003899//GO:0016765//GO:0003676//GO:0008270 DNA primase activity//DNA binding//RNA binding//helicase activity//DNA-directed RNA polymerase activity//transferase activity, transferring alkyl or aryl (other than methyl) groups//nucleic acid binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.26448 BF_2 6.00 26.18 257 478252002 ENN72437.1 265 3.1e-21 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] -- -- -- -- -- K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q15637 170 1.3e-11 Splicing factor 1 OS=Homo sapiens GN=SF1 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.26451 BF_2 315.32 1.59 8570 642934826 XP_008197826.1 4064 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61460 1854 2.4e-205 DEP domain-containing protein 5 OS=Mus musculus GN=Depdc5 PE=1 SV=2 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.26452 BF_2 328.14 3.37 4356 642910567 XP_008200269.1 3542 0.0e+00 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 O55164 1058 2.4e-113 Multiple PDZ domain protein OS=Rattus norvegicus GN=Mpdz PE=1 SV=1 PF05965//PF00595//PF13180 F/Y rich C-terminus//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG3528 FOG: PDZ domain Cluster-8309.26453 BF_2 12.00 0.45 1395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26457 BF_2 264.91 4.43 2787 642937990 XP_008199160.1 1379 2.3e-149 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum]>gi|642937992|ref|XP_008199161.1| PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643 B-box zinc finger -- -- GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.26458 BF_2 166.55 0.56 12762 642926088 XP_008194761.1 1377 1.8e-148 PREDICTED: uncharacterized protein LOC103313398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 153 6.2e-08 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF01222//PF02990//PF15220 Ergosterol biosynthesis ERG4/ERG24 family//Endomembrane protein 70//Hypoxia-inducible lipid droplet-associated GO:0008284//GO:0010884//GO:0001819 positive regulation of cell proliferation//positive regulation of lipid storage//positive regulation of cytokine production -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.26459 BF_2 163.17 1.75 4184 189238206 XP_969047.2 3357 0.0e+00 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum] 512920866 XM_004929683.1 38 1.42833e-07 PREDICTED: Bombyx mori bumetanide-sensitive sodium-(potassium)-chloride cotransporter-like (LOC101736988), partial mRNA K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 2236 5.9e-250 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522//PF00895//PF13520 Amino acid permease//Solute carrier family 12//ATP synthase protein 8//Amino acid permease GO:0006811//GO:0015992//GO:0003333//GO:0015986//GO:0006810//GO:0055085//GO:0006865 ion transport//proton transport//amino acid transmembrane transport//ATP synthesis coupled proton transport//transport//transmembrane transport//amino acid transport GO:0015078//GO:0005215//GO:0015171 hydrogen ion transmembrane transporter activity//transporter activity//amino acid transmembrane transporter activity GO:0016020//GO:0000276 membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2083 Na+/K+ symporter Cluster-8309.26462 BF_2 89.22 2.18 1997 546676934 ERL87858.1 1197 2.1e-128 hypothetical protein D910_05246 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26422 380 4.6e-35 Limulus clotting factor C OS=Carcinoscorpius rotundicauda PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.26464 BF_2 23.39 1.16 1134 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26466 BF_2 3.00 0.45 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26473 BF_2 29.94 1.81 978 189236224 XP_972065.2 518 5.5e-50 PREDICTED: Golgi resident protein GCP60 [Tribolium castaneum]>gi|270005782|gb|EFA02230.1| hypothetical protein TcasGA2_TC007892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H3P7 246 7.8e-20 Golgi resident protein GCP60 OS=Homo sapiens GN=ACBD3 PE=1 SV=4 PF05672//PF00887 MAP7 (E-MAP-115) family//Acyl CoA binding protein GO:0006810//GO:0000226 transport//microtubule cytoskeleton organization GO:0000062 fatty-acyl-CoA binding GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane KOG3878 Protein involved in maintenance of Golgi structure and ER-Golgi transport Cluster-8309.26475 BF_2 4.00 1.15 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26479 BF_2 1.00 0.72 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26481 BF_2 830.40 7.48 4934 642920972 XP_008192636.1 5689 0.0e+00 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12879 THOC2 THO complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12879 B0KWH8 2984 0.0e+00 THO complex subunit 2 OS=Callithrix jacchus GN=THOC2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1874 KEKE-like motif-containing transcription regulator (Rlr1)/suppressor of sin4 Cluster-8309.26484 BF_2 115.36 2.43 2277 642920972 XP_008192636.1 276 1.5e-21 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF01608//PF15741 Outer membrane protein (OmpH-like)//I/LWEQ domain//Ligand-dependent nuclear receptor-interacting factor 1 GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003779//GO:0042974//GO:0051082 actin binding//retinoic acid receptor binding//unfolded protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.26485 BF_2 47.23 1.62 1509 642920972 XP_008192636.1 269 6.3e-21 PREDICTED: THO complex subunit 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15741 Ligand-dependent nuclear receptor-interacting factor 1 GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0042974 retinoic acid receptor binding GO:0005667 transcription factor complex -- -- Cluster-8309.26487 BF_2 36.96 1.95 1078 478260397 ENN80137.1 655 7.8e-66 hypothetical protein YQE_03429, partial [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P20432 578 2.7e-58 Glutathione S-transferase 1-1 OS=Drosophila melanogaster GN=GstD1 PE=1 SV=1 PF04371//PF13409//PF13417//PF02798 Porphyromonas-type peptidyl-arginine deiminase//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006807//GO:0009446 nitrogen compound metabolic process//putrescine biosynthetic process GO:0004668//GO:0005515 protein-arginine deiminase activity//protein binding -- -- -- -- Cluster-8309.26488 BF_2 194.08 4.53 2079 642929027 XP_973541.3 829 1.0e-85 PREDICTED: probable maleylacetoacetate isomerase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9VHD2 786 4.0e-82 Probable maleylacetoacetate isomerase 2 OS=Drosophila melanogaster GN=GstZ2 PE=1 SV=1 PF13409//PF02798//PF00462//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0015035//GO:0009055 protein binding//protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG0868 Glutathione S-transferase Cluster-8309.26489 BF_2 885.13 14.43 2853 189240369 XP_973831.2 1066 4.6e-113 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X4 [Tribolium castaneum] 642932786 XM_968738.3 205 1.41902e-100 PREDICTED: Tribolium castaneum dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (LOC662654), transcript variant X8, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 849 2.7e-89 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26491 BF_2 11.00 0.32 1735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26493 BF_2 20.23 0.48 2044 91087311 XP_975575.1 1011 7.8e-107 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.7e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF01287//PF09415 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//CENP-S associating Centromere protein X GO:0006281//GO:0006448//GO:0006452//GO:0051382//GO:0045901//GO:0045905 DNA repair//regulation of translational elongation//translational frameshifting//kinetochore assembly//positive regulation of translational elongation//positive regulation of translational termination GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.26496 BF_2 26.98 0.32 3812 755959126 XP_011304294.1 2062 2.0e-228 PREDICTED: eukaryotic peptide chain release factor subunit 1 isoform X2 [Fopius arisanus] 642912506 XM_966575.3 578 0 PREDICTED: Tribolium castaneum eukaryotic peptide chain release factor subunit 1 (LOC660337), mRNA K03265 ETF1, ERF1 peptide chain release factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03265 Q9VPH7 2033 1.9e-226 Eukaryotic peptide chain release factor subunit 1 OS=Drosophila melanogaster GN=eRF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0688 Peptide chain release factor 1 (eRF1) Cluster-8309.26499 BF_2 103.58 2.93 1767 642918788 XP_008191584.1 2478 5.2e-277 PREDICTED: uncharacterized protein LOC660407 isoform X1 [Tribolium castaneum] 642918789 XM_008193363.1 545 0 PREDICTED: Tribolium castaneum uncharacterized LOC660407 (LOC660407), transcript variant X2, mRNA -- -- -- -- P47736 647 4.5e-66 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF02145//PF02724 Rap/ran-GAP//CDC45-like protein GO:0051056//GO:0006270 regulation of small GTPase mediated signal transduction//DNA replication initiation GO:0005096 GTPase activator activity -- -- KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.26500 BF_2 142.81 2.07 3180 642917169 XP_008191148.1 800 3.5e-82 PREDICTED: centrosomin isoform X1 [Tribolium castaneum]>gi|270004823|gb|EFA01271.1| centrosomin [Tribolium castaneum] -- -- -- -- -- K16542 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16542 Q9BE52 240 1.3e-18 CDK5 regulatory subunit-associated protein 2 OS=Macaca fascicularis GN=CDK5RAP2 PE=2 SV=1 PF07989//PF02183//PF00769 Centrosomin N-terminal motif 1//Homeobox associated leucine zipper//Ezrin/radixin/moesin family GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0008092 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//cytoskeletal protein binding GO:0005737//GO:0019898//GO:0005815//GO:0005667 cytoplasm//extrinsic component of membrane//microtubule organizing center//transcription factor complex -- -- Cluster-8309.26501 BF_2 739.61 15.55 2277 646691019 KDR07011.1 2372 1.3e-264 WD40 repeat-containing protein SMU1 [Zootermopsis nevadensis] 332372781 BT126569.1 448 0 Dendroctonus ponderosae clone DPO1120_B10 unknown mRNA K13111 SMU1 WD40 repeat-containing protein SMU1 http://www.genome.jp/dbget-bin/www_bget?ko:K13111 Q5ZME8 2226 4.6e-249 WD40 repeat-containing protein SMU1 OS=Gallus gallus GN=SMU1 PE=2 SV=1 PF07569//PF00400 TUP1-like enhancer of split//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0275 Conserved WD40 repeat-containing protein Cluster-8309.26502 BF_2 41.54 0.68 2843 642939366 XP_008193122.1 459 1.1e-42 PREDICTED: uncharacterized protein LOC103312950 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04442//PF13895//PF09085 Cytochrome c oxidase assembly protein CtaG/Cox11//Immunoglobulin domain//Adhesion molecule, immunoglobulin-like GO:0007155 cell adhesion GO:0005507//GO:0005515 copper ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.26503 BF_2 46.58 0.99 2246 642939368 XP_008193127.1 459 8.7e-43 PREDICTED: uncharacterized protein LOC103312950 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09085//PF04442//PF13895 Adhesion molecule, immunoglobulin-like//Cytochrome c oxidase assembly protein CtaG/Cox11//Immunoglobulin domain GO:0007155 cell adhesion GO:0005515//GO:0005507 protein binding//copper ion binding GO:0016020 membrane -- -- Cluster-8309.26504 BF_2 1035.71 22.56 2208 642939368 XP_008193127.1 467 1.0e-43 PREDICTED: uncharacterized protein LOC103312950 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04442//PF13895//PF09085 Cytochrome c oxidase assembly protein CtaG/Cox11//Immunoglobulin domain//Adhesion molecule, immunoglobulin-like GO:0007155 cell adhesion GO:0005515//GO:0005507 protein binding//copper ion binding GO:0016020 membrane -- -- Cluster-8309.26505 BF_2 1182.00 31.86 1839 91077822 XP_970776.1 1374 5.7e-149 PREDICTED: uncharacterized protein LOC659370 [Tribolium castaneum]>gi|642914539|ref|XP_008201719.1| PREDICTED: uncharacterized protein LOC659370 [Tribolium castaneum]>gi|270001483|gb|EEZ97930.1| hypothetical protein TcasGA2_TC000317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01073//PF01370//PF03435//PF00056 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008210//GO:0044237//GO:0008207//GO:0008209//GO:0006694//GO:0055114 estrogen metabolic process//cellular metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0016491//GO:0000166 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.26506 BF_2 1185.69 13.44 3977 91092680 XP_971368.1 4473 0.0e+00 PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911362|ref|XP_008199390.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911364|ref|XP_008199391.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911366|ref|XP_008199393.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|270014815|gb|EFA11263.1| hypothetical protein TcasGA2_TC010798 [Tribolium castaneum] 815809952 XM_012370439.1 590 0 PREDICTED: Linepithema humile AP-2 complex subunit alpha (LOC105674243), transcript variant X2, mRNA K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q7QG73 3987 0.0e+00 AP-2 complex subunit alpha OS=Anopheles gambiae GN=alpha-Adaptin PE=3 SV=4 PF01602//PF02296//PF09090//PF02985//PF02883 Adaptin N terminal region//Alpha adaptin AP2, C-terminal domain//MIF4G like//HEAT repeat//Adaptin C-terminal domain GO:0015031//GO:0006886//GO:0016192//GO:0016070 protein transport//intracellular protein transport//vesicle-mediated transport//RNA metabolic process GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.26507 BF_2 213.52 2.35 4083 91092680 XP_971368.1 3269 0.0e+00 PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911362|ref|XP_008199390.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911364|ref|XP_008199391.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911366|ref|XP_008199393.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|270014815|gb|EFA11263.1| hypothetical protein TcasGA2_TC010798 [Tribolium castaneum] 826423166 XM_012671160.1 402 0 PREDICTED: Monomorium pharaonis AP-2 complex subunit alpha (LOC105831182), mRNA K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q7QG73 2831 0.0e+00 AP-2 complex subunit alpha OS=Anopheles gambiae GN=alpha-Adaptin PE=3 SV=4 PF02296//PF01347//PF02985//PF09090//PF02883//PF01602 Alpha adaptin AP2, C-terminal domain//Lipoprotein amino terminal region//HEAT repeat//MIF4G like//Adaptin C-terminal domain//Adaptin N terminal region GO:0015031//GO:0016192//GO:0006886//GO:0016070//GO:0006869 protein transport//vesicle-mediated transport//intracellular protein transport//RNA metabolic process//lipid transport GO:0008565//GO:0005515//GO:0005319 protein transporter activity//protein binding//lipid transporter activity GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.26508 BF_2 49.82 1.44 1733 478253848 ENN74140.1 681 1.2e-68 hypothetical protein YQE_09113, partial [Dendroctonus ponderosae]>gi|546684654|gb|ERL94271.1| hypothetical protein D910_11552 [Dendroctonus ponderosae] -- -- -- -- -- K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q29N38 565 1.4e-56 AP-2 complex subunit alpha OS=Drosophila pseudoobscura pseudoobscura GN=alpha-Adaptin PE=3 SV=1 PF02296//PF09066//PF02883 Alpha adaptin AP2, C-terminal domain//Beta2-adaptin appendage, C-terminal sub-domain//Adaptin C-terminal domain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- GO:0030131 clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.26513 BF_2 2.90 1.02 405 642918318 XP_008191457.1 463 5.4e-44 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642918317 XM_008193235.1 137 1.18617e-63 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC656006), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 218 5.7e-17 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26514 BF_2 466.22 3.43 5965 478257810 ENN77953.1 2106 2.4e-233 hypothetical protein YQE_05630, partial [Dendroctonus ponderosae] -- -- -- -- -- K14833 NOC2 nucleolar complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14833 Q9VIF0 1452 6.8e-159 Nucleolar complex protein 2 homolog OS=Drosophila melanogaster GN=CG9246 PE=1 SV=1 PF01292//PF00083//PF07690 Prokaryotic cytochrome b561//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006118 transmembrane transport//obsolete electron transport GO:0022857//GO:0009055 transmembrane transporter activity//electron carrier activity GO:0016021 integral component of membrane KOG2256 Predicted protein involved in nuclear export of pre-ribosomes Cluster-8309.26516 BF_2 5.00 1.07 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26518 BF_2 450.05 8.53 2494 91094127 XP_968492.1 2115 9.2e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 4.0e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0030145//GO:0008235//GO:0004177 manganese ion binding//metalloexopeptidase activity//aminopeptidase activity GO:0005737//GO:0005622 cytoplasm//intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.26521 BF_2 181.26 2.16 3796 270010886 EFA07334.1 2927 0.0e+00 hypothetical protein TcasGA2_TC015930 [Tribolium castaneum] -- -- -- -- -- K05288 PIGO phosphatidylinositol glycan, class O http://www.genome.jp/dbget-bin/www_bget?ko:K05288 Q8TEQ8 805 4.6e-84 GPI ethanolamine phosphate transferase 3 OS=Homo sapiens GN=PIGO PE=1 SV=3 PF01676//PF01663//PF00884 Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824//GO:0046872 sulfuric ester hydrolase activity//catalytic activity//metal ion binding -- -- KOG2125 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.26522 BF_2 209.33 2.53 3748 270010886 EFA07334.1 2927 0.0e+00 hypothetical protein TcasGA2_TC015930 [Tribolium castaneum] -- -- -- -- -- K05288 PIGO phosphatidylinositol glycan, class O http://www.genome.jp/dbget-bin/www_bget?ko:K05288 Q8TEQ8 805 4.5e-84 GPI ethanolamine phosphate transferase 3 OS=Homo sapiens GN=PIGO PE=1 SV=3 PF01676//PF01663//PF00884 Metalloenzyme superfamily//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824//GO:0046872 sulfuric ester hydrolase activity//catalytic activity//metal ion binding -- -- KOG2125 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.26527 BF_2 68.31 0.90 3457 91085733 XP_973505.1 2855 0.0e+00 PREDICTED: tRNA (cytosine(34)-C(5))-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15335 NSUN2 tRNA (cytosine34-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15335 Q9W4M9 1723 1.5e-190 tRNA (cytosine(34)-C(5))-methyltransferase OS=Drosophila melanogaster GN=Nsun2 PE=2 SV=1 PF01728//PF01189 FtsJ-like methyltransferase//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.26530 BF_2 206.61 1.16 7763 642935642 XP_008198095.1 2468 3.3e-275 PREDICTED: rho GTPase-activating protein 21-B isoform X4 [Tribolium castaneum] 642935647 XM_008199876.1 210 6.46452e-103 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.3e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF11973//PF13180//PF00620//PF00595 Glycolipid transfer protein (GLTP)//NQRA C-terminal domain//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0055114//GO:0006118//GO:0046836//GO:0007165 oxidation-reduction process//obsolete electron transport//glycolipid transport//signal transduction GO:0016655//GO:0051861//GO:0005515//GO:0017089 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//glycolipid binding//protein binding//glycolipid transporter activity GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.26532 BF_2 107.00 2.87 1849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26534 BF_2 65.57 2.13 1572 91076494 XP_972946.1 556 3.4e-54 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 339 2.1e-30 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 PF01243 Pyridoxamine 5'-phosphate oxidase GO:0008615//GO:0055114 pyridoxine biosynthetic process//oxidation-reduction process GO:0010181//GO:0016491//GO:0004733 FMN binding//oxidoreductase activity//pyridoxamine-phosphate oxidase activity -- -- KOG3374 Cellular repressor of transcription Cluster-8309.26537 BF_2 335.42 1.52 9517 91089789 XP_968303.1 3082 0.0e+00 PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|642933751|ref|XP_008191514.1| PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|642933753|ref|XP_008191521.1| PREDICTED: activated CDC42 kinase 1 [Tribolium castaneum]>gi|270013600|gb|EFA10048.1| hypothetical protein TcasGA2_TC012222 [Tribolium castaneum] -- -- -- -- -- K08886 TNK2, ACK1 activated CDC42 kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08886 Q07912 1421 4.3e-155 Activated CDC42 kinase 1 OS=Homo sapiens GN=TNK2 PE=1 SV=3 PF00018//PF02845//PF02535//PF03153//PF05365//PF08115//PF00069//PF07714 SH3 domain//CUE domain//ZIP Zinc transporter//Transcription factor IIA, alpha/beta subunit//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//SFI toxin family//Protein kinase domain//Protein tyrosine kinase GO:0055085//GO:0009405//GO:0006468//GO:0006367//GO:0030001//GO:0006122 transmembrane transport//pathogenesis//protein phosphorylation//transcription initiation from RNA polymerase II promoter//metal ion transport//mitochondrial electron transport, ubiquinol to cytochrome c GO:0016301//GO:0005524//GO:0046873//GO:0004672//GO:0005515 kinase activity//ATP binding//metal ion transmembrane transporter activity//protein kinase activity//protein binding GO:0016020//GO:0005672//GO:0005576//GO:0005743//GO:0005750 membrane//transcription factor TFIIA complex//extracellular region//mitochondrial inner membrane//mitochondrial respiratory chain complex III KOG0199 ACK and related non-receptor tyrosine kinases Cluster-8309.26540 BF_2 2.00 4.78 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26542 BF_2 3.00 0.93 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26543 BF_2 151.00 2.89 2472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26544 BF_2 3.00 7.17 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26545 BF_2 216.62 1.68 5671 195381919 XP_002049680.1 2495 1.8e-278 GJ20621 [Drosophila virilis]>gi|194144477|gb|EDW60873.1| GJ20621 [Drosophila virilis] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2489 3.7e-279 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF07714//PF00628//PF00433//PF07649//PF00069//PF00564//PF00130 Protein tyrosine kinase//PHD-finger//Protein kinase C terminal domain//C1-like domain//Protein kinase domain//PB1 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016310//GO:0009069//GO:0006468//GO:0055114//GO:0035556 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0008270//GO:0046872//GO:0047134//GO:0004672//GO:0004674 ATP binding//protein binding//zinc ion binding//metal ion binding//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity GO:0005622 intracellular KOG0694 Serine/threonine protein kinase Cluster-8309.26546 BF_2 112.67 0.88 5653 807015446 XP_012155254.1 2269 2.9e-252 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101458667 [Ceratitis capitata] 194753270 XM_001958904.1 363 0 Drosophila ananassae GF12632 (Dana\GF12632), mRNA K06069 PRKCI atypical protein kinase C iota type http://www.genome.jp/dbget-bin/www_bget?ko:K06069 A1Z9X0 2189 2.2e-244 Atypical protein kinase C OS=Drosophila melanogaster GN=aPKC PE=1 SV=1 PF00130//PF00069//PF00628//PF07649//PF00433//PF07714 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase domain//PHD-finger//C1-like domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0055114//GO:0035556//GO:0009069//GO:0006468//GO:0016310 oxidation-reduction process//intracellular signal transduction//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0047134//GO:0005515//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//protein-disulfide reductase activity//protein binding//ATP binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.26548 BF_2 36.34 0.34 4814 642920287 XP_008192284.1 3601 0.0e+00 PREDICTED: N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1 [Tribolium castaneum]>gi|642920289|ref|XP_008192285.1| PREDICTED: N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X1 [Tribolium castaneum] 642920290 XM_970509.2 763 0 PREDICTED: Tribolium castaneum N-alpha-acetyltransferase 16, NatA auxiliary subunit (LOC664508), transcript variant X3, mRNA K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 Q5R4J9 2436 4.4e-273 N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Pongo abelii GN=NAA15 PE=2 SV=1 PF13174//PF03601//PF13181//PF13414//PF06552//PF13176//PF00515//PF13371 Tetratricopeptide repeat//Conserved hypothetical protein 698//Tetratricopeptide repeat//TPR repeat//Plant specific mitochondrial import receptor subunit TOM20//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0045040 protein import into mitochondrial outer membrane GO:0005515 protein binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane KOG1156 N-terminal acetyltransferase Cluster-8309.26551 BF_2 786.00 22.28 1763 332374070 AEE62176.1 1141 5.7e-122 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9SU79 466 4.3e-45 Probable polyamine oxidase 5 OS=Arabidopsis thaliana GN=PAO5 PE=2 SV=1 PF01593//PF12831//PF07992//PF01266 Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.26553 BF_2 8.69 0.35 1317 270008369 EFA04817.1 339 4.2e-29 hypothetical protein TcasGA2_TC014867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NPA5 233 3.4e-18 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF04988//PF13465//PF00096//PF06397 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain -- -- GO:0003677//GO:0046872//GO:0005506 DNA binding//metal ion binding//iron ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.26554 BF_2 380.51 3.25 5178 642922636 XP_971090.3 2313 2.1e-257 PREDICTED: uncharacterized protein LOC659719 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 Q6P7W0 366 5.0e-33 Sentrin-specific protease 6 OS=Mus musculus GN=Senp6 PE=2 SV=3 PF02902//PF02944 Ulp1 protease family, C-terminal catalytic domain//BESS motif GO:0006508 proteolysis GO:0008234//GO:0003677 cysteine-type peptidase activity//DNA binding -- -- KOG0779 Protease, Ulp1 family Cluster-8309.26557 BF_2 17.22 0.69 1325 642925105 XP_008194171.1 777 6.9e-80 PREDICTED: decaprenyl-diphosphate synthase subunit 2-like [Tribolium castaneum]>gi|270008056|gb|EFA04504.1| hypothetical protein TcasGA2_TC014812 [Tribolium castaneum] -- -- -- -- -- K12505 PDSS2 decaprenyl-diphosphate synthase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12505 Q5U2R1 373 2.0e-34 Decaprenyl-diphosphate synthase subunit 2 OS=Rattus norvegicus GN=Pdss2 PE=2 SV=1 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.26558 BF_2 470.78 13.10 1790 642925105 XP_008194171.1 1052 1.2e-111 PREDICTED: decaprenyl-diphosphate synthase subunit 2-like [Tribolium castaneum]>gi|270008056|gb|EFA04504.1| hypothetical protein TcasGA2_TC014812 [Tribolium castaneum] -- -- -- -- -- K12505 PDSS2 decaprenyl-diphosphate synthase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12505 Q33DR3 506 1.0e-49 Decaprenyl-diphosphate synthase subunit 2 OS=Mus musculus GN=Pdss2 PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.26559 BF_2 43.00 3.16 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26560 BF_2 517.35 45.77 760 242017482 XP_002429217.1 419 1.3e-38 myotrophin, putative [Pediculus humanus corporis]>gi|212514106|gb|EEB16479.1| myotrophin, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q7T2B9 295 1.3e-25 Myotrophin OS=Danio rerio GN=mtpn PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26561 BF_2 280.67 4.01 3214 478251696 ENN72150.1 1468 1.2e-159 hypothetical protein YQE_11207, partial [Dendroctonus ponderosae]>gi|546680948|gb|ERL91122.1| hypothetical protein D910_08463 [Dendroctonus ponderosae] -- -- -- -- -- K14308 NUP54, NUP57 nuclear pore complex protein Nup54 http://www.genome.jp/dbget-bin/www_bget?ko:K14308 Q8BTS4 726 5.6e-75 Nuclear pore complex protein Nup54 OS=Mus musculus GN=Nup54 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3091 Nuclear pore complex, p54 component (sc Nup57) Cluster-8309.26562 BF_2 188.69 5.32 1770 642912671 XP_969018.2 897 1.1e-93 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 P28039 495 1.9e-48 Acyloxyacyl hydrolase OS=Homo sapiens GN=AOAH PE=1 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26563 BF_2 71.60 1.97 1811 642912671 XP_969018.2 897 1.1e-93 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 O35298 533 7.6e-53 Acyloxyacyl hydrolase OS=Mus musculus GN=Aoah PE=2 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26564 BF_2 23.63 0.41 2725 642921021 XP_974765.2 814 7.2e-84 PREDICTED: uncharacterized protein LOC663634 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00930 Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508 proteolysis -- -- -- -- -- -- Cluster-8309.26565 BF_2 24.33 0.94 1375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26569 BF_2 174.62 6.24 1458 91088189 XP_972722.1 975 8.3e-103 PREDICTED: dehydrodolichyl diphosphate synthase [Tribolium castaneum]>gi|270012136|gb|EFA08584.1| hypothetical protein TcasGA2_TC006239 [Tribolium castaneum] -- -- -- -- -- K11778 DHDDS, RER2, SRT1 ditrans,polycis-polyprenyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K11778 Q86SQ9 744 2.1e-77 Dehydrodolichyl diphosphate syntase complex subunit DHDDS OS=Homo sapiens GN=DHDDS PE=1 SV=3 PF01255//PF01991 Putative undecaprenyl diphosphate synthase//ATP synthase (E/31 kDa) subunit GO:0015991//GO:0015992//GO:0006119 ATP hydrolysis coupled proton transport//proton transport//oxidative phosphorylation GO:0046961//GO:0016765//GO:0016740 proton-transporting ATPase activity, rotational mechanism//transferase activity, transferring alkyl or aryl (other than methyl) groups//transferase activity GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1602 Cis-prenyltransferase Cluster-8309.26577 BF_2 69.00 0.41 7251 270013629 EFA10077.1 304 2.6e-24 hypothetical protein TcasGA2_TC012253 [Tribolium castaneum] -- -- -- -- -- K05668 ABCC5 ATP-binding cassette, subfamily C (CFTR/MRP), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05668 Q9R1X5 168 6.4e-10 Multidrug resistance-associated protein 5 OS=Mus musculus GN=Abcc5 PE=1 SV=2 PF00664//PF01799 ABC transporter transmembrane region//[2Fe-2S] binding domain GO:0055085//GO:0006810//GO:0055114 transmembrane transport//transport//oxidation-reduction process GO:0005524//GO:0016491//GO:0046872//GO:0042626 ATP binding//oxidoreductase activity//metal ion binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.26578 BF_2 606.75 8.70 3204 642933785 XP_008197283.1 3849 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933787|ref|XP_008197292.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum]>gi|642933789|ref|XP_008197304.1| PREDICTED: multidrug resistance-associated protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2326 1.6e-260 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF00437//PF00664//PF13304//PF01926//PF00005//PF17001//PF03193 Type II/IV secretion system protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Protein of unknown function, DUF258 GO:0055085//GO:0009306//GO:0006810 transmembrane transport//protein secretion//transport GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.26579 BF_2 66.29 0.36 8026 642918353 XP_008199964.1 4724 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1M386 2376 6.6e-266 Rap guanine nucleotide exchange factor 2 OS=Rattus norvegicus GN=Rapgef2 PE=1 SV=2 PF00788//PF13180//PF00617//PF00595 Ras association (RalGDS/AF-6) domain//PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF) GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.26583 BF_2 91.14 1.20 3452 642914124 XP_008201554.1 3454 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum]>gi|642914126|ref|XP_008201555.1| PREDICTED: colorectal mutant cancer protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 590 3.6e-59 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26584 BF_2 5.00 2.25 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26586 BF_2 85.86 0.67 5611 642921234 XP_008192774.1 1587 3.5e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921235 XM_008194553.1 286 2.63509e-145 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 677 4.7e-69 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF13606//PF06971//PF14604//PF00023//PF00018 Ankyrin repeat//Putative DNA-binding protein N-terminus//Variant SH3 domain//Ankyrin repeat//SH3 domain GO:0045892//GO:0051775 negative regulation of transcription, DNA-templated//response to redox state GO:0005515 protein binding GO:0005737 cytoplasm KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.26587 BF_2 27.00 1.65 973 820805570 AKG92776.1 824 1.8e-85 enhancer of split mgamma protein 3 [Leptinotarsa decemlineata] 642932734 XM_967400.3 155 2.95113e-73 PREDICTED: Tribolium castaneum enhancer of split mgamma protein (LOC661225), mRNA K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 Q01069 345 2.6e-31 Enhancer of split mbeta protein OS=Drosophila melanogaster GN=HLHmbeta PE=2 SV=2 PF07527//PF00010 Hairy Orange//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.26588 BF_2 32.48 1.39 1268 642926860 XP_971810.2 262 3.4e-20 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20662 142 1.2e-07 Zinc finger Y-chromosomal protein 2 OS=Mus musculus GN=Zfy2 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.26589 BF_2 5.00 0.39 820 478251273 ENN71744.1 194 1.7e-12 hypothetical protein YQE_11564, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NPA5 134 6.3e-07 Zinc finger protein 64 homolog, isoforms 1 and 2 OS=Homo sapiens GN=ZFP64 PE=1 SV=3 PF16622//PF03367//PF00096//PF13465//PF01155//PF06397//PF02150 zinc-finger C2H2-type//ZPR1 zinc-finger domain//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//RNA polymerases M/15 Kd subunit GO:0006144//GO:0006464//GO:0006351//GO:0006206 purine nucleobase metabolic process//cellular protein modification process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0016151//GO:0003899//GO:0003677//GO:0046872//GO:0005506//GO:0008270 nickel cation binding//DNA-directed RNA polymerase activity//DNA binding//metal ion binding//iron ion binding//zinc ion binding GO:0005730 nucleolus -- -- Cluster-8309.26590 BF_2 12.48 0.36 1757 307166389 EFN60526.1 163 1.4e-08 Protein hunchback [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26595 BF_2 888.00 21.27 2034 91085957 XP_971290.1 2324 4.3e-259 PREDICTED: phosphatidylinositide phosphatase SAC1 [Tribolium castaneum]>gi|270009938|gb|EFA06386.1| hypothetical protein TcasGA2_TC009264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0I6 1474 6.5e-162 Phosphatidylinositide phosphatase SAC1 OS=Drosophila melanogaster GN=Sac1 PE=2 SV=1 PF02383 SacI homology domain -- -- GO:0042578 phosphoric ester hydrolase activity -- -- KOG1889 Putative phosphoinositide phosphatase Cluster-8309.26598 BF_2 78.00 3.90 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01787 Ilarvirus coat protein GO:0006413 translational initiation GO:0003723 RNA binding GO:0019012 virion -- -- Cluster-8309.26599 BF_2 61.57 1.28 2292 642938614 XP_008199866.1 926 6.3e-97 PREDICTED: WAS protein family homolog 1 [Tribolium castaneum] -- -- -- -- -- K18461 WASH1 WAS protein family homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18461 A4IG59 527 4.8e-52 WAS protein family homolog 1 OS=Danio rerio GN=Wash1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26600 BF_2 24.00 0.58 2011 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26601 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26603 BF_2 1.00 12.83 227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26604 BF_2 58.14 0.51 5010 189238721 XP_970605.2 2192 2.2e-243 PREDICTED: collagen type IV alpha-3-binding protein isoform X1 [Tribolium castaneum]>gi|270010089|gb|EFA06537.1| hypothetical protein TcasGA2_TC009441 [Tribolium castaneum] 194753683 XM_001959104.1 36 2.2156e-06 Drosophila ananassae GF12210 (Dana\GF12210), mRNA K08283 COL4A3BP collagen type IV alpha-3-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08283 Q6VVX2 1273 3.3e-138 Collagen type IV alpha-3-binding protein OS=Cricetulus griseus GN=COL4A3BP PE=1 SV=1 PF01852 START domain -- -- GO:0005543//GO:0008289 phospholipid binding//lipid binding -- -- KOG1739 Serine/threonine protein kinase GPBP Cluster-8309.26605 BF_2 16.16 0.93 1012 546672885 ERL84608.1 887 9.2e-93 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 694 9.1e-72 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.26607 BF_2 65.00 1.59 1997 478250939 ENN71423.1 362 1.4e-31 hypothetical protein YQE_11843, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7U0 148 3.7e-08 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26608 BF_2 96.56 1.15 3795 642918758 XP_008191571.1 825 5.3e-85 PREDICTED: ras association domain-containing protein 8 [Tribolium castaneum]>gi|270005673|gb|EFA02121.1| hypothetical protein TcasGA2_TC007768 [Tribolium castaneum] -- -- -- -- -- K09855 RASSF7_8 Ras association domain-containing protein 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K09855 Q8CJ96 306 3.3e-26 Ras association domain-containing protein 8 OS=Mus musculus GN=Rassf8 PE=2 SV=1 PF10186//PF00788//PF07851//PF10473 Vacuolar sorting 38 and autophagy-related subunit 14//Ras association (RalGDS/AF-6) domain//TMPIT-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0010508//GO:0007165 positive regulation of autophagy//signal transduction GO:0042803//GO:0008134//GO:0045502 protein homodimerization activity//transcription factor binding//dynein binding GO:0016021//GO:0030286//GO:0005667 integral component of membrane//dynein complex//transcription factor complex KOG1574 Predicted cell growth/differentiation regulator, contains RA domain Cluster-8309.26609 BF_2 75.58 1.00 3457 642918758 XP_008191571.1 1330 1.3e-143 PREDICTED: ras association domain-containing protein 8 [Tribolium castaneum]>gi|270005673|gb|EFA02121.1| hypothetical protein TcasGA2_TC007768 [Tribolium castaneum] -- -- -- -- -- K09855 RASSF7_8 Ras association domain-containing protein 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K09855 Q8CJ96 186 2.5e-12 Ras association domain-containing protein 8 OS=Mus musculus GN=Rassf8 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1574 Predicted cell growth/differentiation regulator, contains RA domain Cluster-8309.26610 BF_2 308.00 7.30 2052 642924686 XP_008194398.1 1528 8.8e-167 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 514 1.4e-50 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF00999//PF09515//PF11770 Sodium/hydrogen exchanger family//Thiamine transporter protein (Thia_YuaJ)//GRB2-binding adapter (GAPT) GO:0015888//GO:0006812//GO:0006885//GO:0055085 thiamine transport//cation transport//regulation of pH//transmembrane transport GO:0015299//GO:0015234 solute:proton antiporter activity//thiamine transmembrane transporter activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.26614 BF_2 75.01 0.41 7925 91093409 XP_967547.1 277 3.9e-21 PREDICTED: sarcoplasmic calcium-binding protein 1 isoform X2 [Tribolium castaneum]>gi|270015413|gb|EFA11861.1| hypothetical protein TcasGA2_TC005103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05946 200 1.4e-13 Sarcoplasmic calcium-binding protein 1 OS=Astacus leptodactylus PE=1 SV=1 -- -- -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.26616 BF_2 434.15 6.48 3088 549438529 AGX25153.1 1932 1.9e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q6AX23 834 1.6e-87 Sulfhydryl oxidase 2 OS=Xenopus laevis GN=qsox2 PE=2 SV=1 PF04777//PF00085 Erv1 / Alr family//Thioredoxin GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.26617 BF_2 111.00 2.38 2239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26619 BF_2 21.85 1.07 1141 642931814 XP_008196744.1 1205 1.4e-129 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 865 1.5e-91 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF06584 Cytochrome P450//DIRP GO:0055114//GO:0007049//GO:0006351 oxidation-reduction process//cell cycle//transcription, DNA-templated GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0017053 transcriptional repressor complex -- -- Cluster-8309.26620 BF_2 32.89 0.62 2497 642922682 XP_008193278.1 585 2.4e-57 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X10 [Tribolium castaneum] -- -- -- -- -- K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 Q9JI18 507 1.1e-49 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.26623 BF_2 14.81 0.80 1057 332372985 AEE61634.1 1287 4.0e-139 unknown [Dendroctonus ponderosae] 642937798 XM_008202083.1 221 6.57658e-110 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8HXM1 717 2.0e-74 Cleavage stimulation factor subunit 2 OS=Bos taurus GN=CSTF2 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.26624 BF_2 19.66 0.60 1648 270000744 EEZ97191.1 1343 2.0e-145 hypothetical protein TcasGA2_TC004378 [Tribolium castaneum] 642937798 XM_008202083.1 221 1.03663e-109 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8BIQ5 711 1.6e-73 Cleavage stimulation factor subunit 2 OS=Mus musculus GN=Cstf2 PE=1 SV=2 PF16367//PF00076//PF14304 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transcription termination and cleavage factor C-terminal GO:0031124 mRNA 3'-end processing GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.26628 BF_2 67.53 0.31 9462 91090153 XP_972190.1 8603 0.0e+00 PREDICTED: CAD protein [Tribolium castaneum]>gi|270013749|gb|EFA10197.1| hypothetical protein TcasGA2_TC012392 [Tribolium castaneum] 218526269 EU860157.1 823 0 Strangalia bicolor carbamoyl-phosphate synthase (CAD) gene, partial cds K11540 CAD carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase http://www.genome.jp/dbget-bin/www_bget?ko:K11540 P05990 7138 0.0e+00 CAD protein OS=Drosophila melanogaster GN=r PE=1 SV=3 PF07722//PF00185//PF00113//PF02655//PF02786//PF01979//PF07478//PF02729 Peptidase C26//Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain//Enolase, C-terminal TIM barrel domain//ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//Amidohydrolase family//D-ala D-ala ligase C-terminus//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0009094//GO:0006206//GO:0006522//GO:0006807//GO:0000162//GO:0006543//GO:0009252//GO:0006520//GO:0070409//GO:0046436//GO:0006531//GO:0006094//GO:0006571//GO:0006541//GO:0006096//GO:0006207 L-phenylalanine biosynthetic process//pyrimidine nucleobase metabolic process//alanine metabolic process//nitrogen compound metabolic process//tryptophan biosynthetic process//glutamine catabolic process//peptidoglycan biosynthetic process//cellular amino acid metabolic process//carbamoyl phosphate biosynthetic process//D-alanine metabolic process//aspartate metabolic process//gluconeogenesis//tyrosine biosynthetic process//glutamine metabolic process//glycolytic process//'de novo' pyrimidine nucleobase biosynthetic process GO:0016597//GO:0016812//GO:0008716//GO:0046872//GO:0004070//GO:0000287//GO:0016743//GO:0005524//GO:0016787//GO:0004634 amino acid binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides//D-alanine-D-alanine ligase activity//metal ion binding//aspartate carbamoyltransferase activity//magnesium ion binding//carboxyl- or carbamoyltransferase activity//ATP binding//hydrolase activity//phosphopyruvate hydratase activity GO:0000015//GO:0009347 phosphopyruvate hydratase complex//aspartate carbamoyltransferase complex KOG0370 Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) Cluster-8309.26631 BF_2 11.11 0.69 961 642922720 XP_008193296.1 145 9.6e-07 PREDICTED: LIM domain transcription factor LMO4.1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05063 MT-A70 GO:0006139 nucleobase-containing compound metabolic process GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.26633 BF_2 150.48 10.27 900 642922720 XP_008193296.1 744 3.1e-76 PREDICTED: LIM domain transcription factor LMO4.1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61968 471 5.8e-46 LIM domain transcription factor LMO4 OS=Homo sapiens GN=LMO4 PE=1 SV=1 PF01258//PF00412 Prokaryotic dksA/traR C4-type zinc finger//LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.26634 BF_2 37.28 3.82 695 642922720 XP_008193296.1 145 6.9e-07 PREDICTED: LIM domain transcription factor LMO4.1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05063 MT-A70 GO:0006139 nucleobase-containing compound metabolic process GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.26638 BF_2 8.16 0.44 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26639 BF_2 185.70 3.44 2543 642932775 XP_008196978.1 1066 4.1e-113 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X2 [Tribolium castaneum] 642932786 XM_968738.3 205 1.26377e-100 PREDICTED: Tribolium castaneum dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (LOC662654), transcript variant X8, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 849 2.4e-89 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26640 BF_2 156.61 2.39 3031 642932773 XP_008196977.1 3190 0.0e+00 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 759067243 XM_011344784.1 294 5.05559e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 6.2e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF13492//PF00233//PF01590//PF07533//PF13185 GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//BRK domain//GAF domain GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114//GO:0005515//GO:0016817 3',5'-cyclic-nucleotide phosphodiesterase activity//protein binding//hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.26641 BF_2 2.00 1.11 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26642 BF_2 275.16 4.28 2977 642932773 XP_008196977.1 1066 4.7e-113 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 642932786 XM_968738.3 205 1.48149e-100 PREDICTED: Tribolium castaneum dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 (LOC662654), transcript variant X8, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 849 2.8e-89 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26643 BF_2 90.68 1.43 2941 642932773 XP_008196977.1 3190 0.0e+00 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 759067243 XM_011344784.1 294 4.90367e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 6.0e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF13185//PF07533//PF00233//PF01590//PF13492 GAF domain//BRK domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005515//GO:0016817//GO:0004114 protein binding//hydrolase activity, acting on acid anhydrides//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.26647 BF_2 74.68 0.72 4642 546676723 ERL87679.1 1323 1.2e-142 hypothetical protein D910_05069 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24478 594 1.6e-59 Centrosome-associated zinc finger protein CP190 OS=Drosophila melanogaster GN=Cp190 PE=1 SV=2 PF00096//PF16622//PF00651 Zinc finger, C2H2 type//zinc-finger C2H2-type//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.26650 BF_2 655.53 79.98 630 270015668 EFA12116.1 328 3.8e-28 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11162 RDH14 retinol dehydrogenase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11162 Q9HBH5 206 2.2e-15 Retinol dehydrogenase 14 OS=Homo sapiens GN=RDH14 PE=1 SV=1 PF00106//PF01733 short chain dehydrogenase//Nucleoside transporter GO:0015858//GO:0008152//GO:0006810 nucleoside transport//metabolic process//transport GO:0016491//GO:0005337 oxidoreductase activity//nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.26652 BF_2 32.20 8.25 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26654 BF_2 108.47 0.43 10795 642940144 XP_008200104.1 3309 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 1673 2.9e-184 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 PF04841//PF04840 Vps16, N-terminal region//Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.26658 BF_2 168.10 2.07 3687 642936562 XP_008198486.1 1449 2.3e-157 PREDICTED: somatostatin receptor type 2 isoform X1 [Tribolium castaneum] 462360042 APGK01029530.1 119 1.17964e-52 Dendroctonus ponderosae Seq01029540, whole genome shotgun sequence K04218 SSTR2 somatostatin receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04218 P30874 580 5.5e-58 Somatostatin receptor type 2 OS=Homo sapiens GN=SSTR2 PE=1 SV=1 PF00001//PF13994 7 transmembrane receptor (rhodopsin family)//PgaD-like protein GO:0007186//GO:0042710 G-protein coupled receptor signaling pathway//biofilm formation GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.2666 BF_2 3.00 0.90 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26660 BF_2 285.17 9.60 1530 91089889 XP_966960.1 1779 5.1e-196 PREDICTED: actin-like protein 6B [Tribolium castaneum]>gi|270013557|gb|EFA10005.1| hypothetical protein TcasGA2_TC012175 [Tribolium castaneum] 676438341 XM_009050250.1 51 3.05568e-15 Lottia gigantea hypothetical protein mRNA K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 P86173 1118 9.4e-121 Actin-like protein 6B OS=Rattus norvegicus GN=Actl6b PE=1 SV=2 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0679 Actin-related protein - Arp4p/Act3p Cluster-8309.26662 BF_2 165.55 3.32 2370 270004866 EFA01314.1 634 4.7e-63 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 473 9.0e-46 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26663 BF_2 224.81 2.28 4414 332376575 AEE63427.1 1298 8.8e-140 unknown [Dendroctonus ponderosae]>gi|546673735|gb|ERL85291.1| hypothetical protein D910_02712 [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5FWL7 827 1.5e-86 Palmitoyltransferase ZDHHC15 OS=Xenopus laevis GN=zdhhc15 PE=2 SV=1 PF00219//PF01529//PF02714//PF01309 Insulin-like growth factor binding protein//DHHC palmitoyltransferase//Calcium-dependent channel, 7TM region, putative phosphate//Equine arteritis virus small envelope glycoprotein GO:0001558 regulation of cell growth GO:0005520//GO:0008270 insulin-like growth factor binding//zinc ion binding GO:0005576//GO:0016020//GO:0019031//GO:0016942 extracellular region//membrane//viral envelope//insulin-like growth factor binding protein complex KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.26664 BF_2 3.00 0.46 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26667 BF_2 141.68 1.49 4253 642935245 XP_008197928.1 4434 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 727 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1745 5.1e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF16656//PF13895//PF00041//PF05506 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//Domain of unknown function (DUF756) GO:0016042//GO:0006771//GO:0009395//GO:0019497 lipid catabolic process//riboflavin metabolic process//phospholipid catabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0004629//GO:0005515 acid phosphatase activity//metal ion binding//phospholipase C activity//protein binding -- -- -- -- Cluster-8309.26668 BF_2 2.00 0.37 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26670 BF_2 741.70 5.57 5854 91094283 XP_970886.1 3594 0.0e+00 PREDICTED: BTB/POZ domain-containing protein 7 [Tribolium castaneum]>gi|270014398|gb|EFA10846.1| hypothetical protein TcasGA2_TC001623 [Tribolium castaneum] -- -- -- -- -- K10479 BTBD7 BTB/POZ domain-containing protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10479 Q9P203 1428 4.1e-156 BTB/POZ domain-containing protein 7 OS=Homo sapiens GN=BTBD7 PE=1 SV=3 PF07127//PF00651 Late nodulin protein//BTB/POZ domain GO:0009878 nodule morphogenesis GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG2838 Uncharacterized conserved protein, contains BTB/POZ domain Cluster-8309.26671 BF_2 15.47 1.51 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26672 BF_2 844.00 27.57 1568 91078056 XP_971325.1 1674 7.9e-184 PREDICTED: endoplasmic reticulum lectin 1 [Tribolium castaneum]>gi|270001404|gb|EEZ97851.1| hypothetical protein TcasGA2_TC000223 [Tribolium castaneum] -- -- -- -- -- K14008 ERLEC1, XTP3B endoplasmic reticulum lectin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14008 Q5R8S4 957 4.5e-102 Endoplasmic reticulum lectin 1 OS=Pongo abelii GN=ERLEC1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3394 Protein OS-9 Cluster-8309.26673 BF_2 35.29 1.03 1721 270010103 EFA06551.1 421 1.7e-38 hypothetical protein TcasGA2_TC009460 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5HZY0 235 2.6e-18 UBX domain-containing protein 4 OS=Rattus norvegicus GN=Ubxn4 PE=2 SV=1 PF05279//PF00789//PF05602 Aspartyl beta-hydroxylase N-terminal region//UBX domain//Cleft lip and palate transmembrane protein 1 (CLPTM1) -- -- GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains Cluster-8309.26675 BF_2 41.00 1.90 1190 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26676 BF_2 1.00 7.23 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26678 BF_2 3.00 2.52 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.26679 BF_2 2.00 34.42 220 768410654 XP_011559576.1 236 6.1e-18 PREDICTED: embryonic polarity protein dorsal-like isoform X1 [Plutella xylostella] -- -- -- -- -- K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 206 7.6e-16 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.26682 BF_2 1199.79 13.04 4135 642938616 XP_008199867.1 2131 2.1e-236 PREDICTED: epidermal growth factor receptor kinase substrate 8 [Tribolium castaneum] -- -- -- -- -- K17277 EPS8 epidermal growth factor receptor kinase substrate 8 http://www.genome.jp/dbget-bin/www_bget?ko:K17277 Q9H6S3 571 6.8e-57 Epidermal growth factor receptor kinase substrate 8-like protein 2 OS=Homo sapiens GN=EPS8L2 PE=1 SV=2 PF00536//PF08416//PF14604//PF00018//PF02198 SAM domain (Sterile alpha motif)//Phosphotyrosine-binding domain//Variant SH3 domain//SH3 domain//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus KOG3557 Epidermal growth factor receptor kinase substrate Cluster-8309.26684 BF_2 63.61 3.92 966 91077764 XP_968340.1 874 2.8e-91 PREDICTED: semaphorin-2A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XZC8 664 2.6e-68 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.26687 BF_2 27.55 0.31 3991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26689 BF_2 56.10 0.94 2783 189236857 XP_974302.2 1085 2.8e-115 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum] 541975047 XM_005440594.1 35 4.40089e-06 PREDICTED: Falco cherrug solute carrier family 36 (proton/amino acid symporter), member 1 (SLC36A1), mRNA K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 435 2.7e-41 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2669 BF_2 6.00 0.64 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26690 BF_2 62.94 0.54 5134 546687608 ERL96229.1 1696 7.3e-186 hypothetical protein D910_01506 [Dendroctonus ponderosae]>gi|546687612|gb|ERL96230.1| hypothetical protein D910_01507 [Dendroctonus ponderosae] 817204838 XM_012422887.1 468 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X5, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1555 6.7e-171 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.26691 BF_2 22.09 0.61 1802 642938452 XP_008199809.1 408 5.7e-37 PREDICTED: sarcoplasmic calcium-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02635 221 1.1e-16 Sarcoplasmic calcium-binding protein, beta chain OS=Penaeus sp. PE=1 SV=1 PF13202//PF09298//PF00036//PF13833//PF13405//PF13499 EF hand//Fumarylacetoacetase N-terminal//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0042207//GO:0006570//GO:0009072 styrene catabolic process//tyrosine metabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005509 fumarylacetoacetase activity//calcium ion binding -- -- -- -- Cluster-8309.26693 BF_2 280.94 12.83 1203 91092692 XP_971829.1 397 7.2e-36 PREDICTED: uncharacterized protein LOC660509 [Tribolium castaneum]>gi|642911393|ref|XP_008199405.1| PREDICTED: uncharacterized protein LOC660509 [Tribolium castaneum]>gi|270015139|gb|EFA11587.1| immune deficiency [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00531//PF10541 Death domain//Nuclear envelope localisation domain GO:0007165 signal transduction GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.26695 BF_2 276.59 6.73 2007 270010378 EFA06826.1 2294 1.3e-255 hypothetical protein TcasGA2_TC009768 [Tribolium castaneum] 642928761 XM_008201551.1 641 0 PREDICTED: Tribolium castaneum nephrin (LOC663236), mRNA -- -- -- -- Q9R044 217 3.7e-16 Nephrin OS=Rattus norvegicus GN=Nphs1 PE=1 SV=2 PF04850//PF00041//PF13895 Baculovirus E66 occlusion-derived virus envelope protein//Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules Cluster-8309.26698 BF_2 31.75 0.34 4248 642938759 XP_008199876.1 658 1.4e-65 PREDICTED: protein transport protein Sec16B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26699 BF_2 71.32 0.65 4855 546681199 ERL91334.1 423 2.8e-38 hypothetical protein D910_08666 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04145 Ctr copper transporter family GO:0035434//GO:0006825 copper ion transmembrane transport//copper ion transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.2670 BF_2 14.00 0.93 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26701 BF_2 16.91 0.56 1543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26702 BF_2 7.90 0.50 943 478263116 ENN81509.1 304 3.4e-25 hypothetical protein YQE_02038, partial [Dendroctonus ponderosae]>gi|546672296|gb|ERL84223.1| hypothetical protein D910_01601 [Dendroctonus ponderosae]>gi|546675497|gb|ERL86682.1| hypothetical protein D910_04088 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 222 4.5e-17 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.26703 BF_2 550.00 19.19 1486 91078538 XP_970648.1 1187 2.2e-127 PREDICTED: FIT family protein CG10671 [Tribolium castaneum]>gi|270003835|gb|EFA00283.1| hypothetical protein TcasGA2_TC003116 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRJ2 826 6.6e-87 FIT family protein CG10671 OS=Drosophila melanogaster GN=CG10671 PE=1 SV=1 PF10261 Inositol phospholipid synthesis and fat-storage-inducing TM GO:0019915 lipid storage -- -- GO:0005789 endoplasmic reticulum membrane KOG3750 Inositol phospholipid synthesis protein, Scs3p Cluster-8309.26704 BF_2 48.30 12.30 451 332376915 AEE63597.1 286 2.0e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 224 1.3e-17 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26705 BF_2 11.72 2.87 458 478261416 ENN80793.1 162 4.9e-09 hypothetical protein YQE_02802, partial [Dendroctonus ponderosae]>gi|546680989|gb|ERL91163.1| hypothetical protein D910_08503 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- -- -- Cluster-8309.26706 BF_2 161.00 25.33 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26709 BF_2 33.39 0.34 4429 642934390 XP_008197640.1 2987 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 7.0379e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.3e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553//PF00620 Acyltransferase//RhoGAP domain GO:0007165//GO:0008152 signal transduction//metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.2671 BF_2 4.00 0.42 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26710 BF_2 3.00 13.09 257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26713 BF_2 7.61 0.48 955 31202411 XP_310154.1 242 5.4e-18 AGAP009537-PA [Anopheles gambiae str. PEST]>gi|30178199|gb|EAA05914.2| AGAP009537-PA [Anopheles gambiae str. PEST] 662193578 XM_008471481.1 65 3.10675e-23 PREDICTED: Diaphorina citri cytochrome c (LOC103507048), transcript variant X2, mRNA K08738 CYC cytochrome c http://www.genome.jp/dbget-bin/www_bget?ko:K08738 P84030 238 6.4e-19 Cytochrome c-2 OS=Ceratitis capitata PE=1 SV=2 PF06817 Reverse transcriptase thumb domain GO:0006118//GO:0022900//GO:0006278 obsolete electron transport//electron transport chain//RNA-dependent DNA replication GO:0009055//GO:0005506//GO:0020037//GO:0003964 electron carrier activity//iron ion binding//heme binding//RNA-directed DNA polymerase activity GO:0005739//GO:0070469 mitochondrion//respiratory chain KOG3453 Cytochrome c Cluster-8309.26714 BF_2 1606.95 31.41 2427 642930397 XP_008196382.1 1651 5.7e-181 PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930399|ref|XP_008196383.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930401|ref|XP_008196384.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|270010720|gb|EFA07168.1| hypothetical protein TcasGA2_TC010167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7JUY7 659 2.5e-67 PTB domain-containing adapter protein ced-6 OS=Drosophila melanogaster GN=ced-6 PE=1 SV=1 PF14719//PF00640//PF08416 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG3536 Adaptor protein CED-6, contains PTB domain Cluster-8309.26717 BF_2 342.00 5.25 3014 817080920 XP_012262945.1 3395 0.0e+00 PREDICTED: DNA excision repair protein haywire [Athalia rosae] 242005968 XM_002423787.1 471 0 Pediculus humanus corporis DNA excision repair protein haywire, putative, mRNA K10843 ERCC3, XPB DNA excision repair protein ERCC-3 http://www.genome.jp/dbget-bin/www_bget?ko:K10843 Q02870 3254 0.0e+00 DNA excision repair protein haywire OS=Drosophila melanogaster GN=hay PE=1 SV=2 PF00270//PF00176//PF04851 DEAD/DEAH box helicase//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG1123 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 3'-5' helicase subunit SSL2 Cluster-8309.26718 BF_2 14.10 3.33 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26720 BF_2 13.00 1.30 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02902 Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- -- -- Cluster-8309.26721 BF_2 62.31 0.73 3869 642938137 XP_008199781.1 1838 1.9e-202 PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|642938140|ref|XP_008199782.1| PREDICTED: serine/threonine-protein kinase PRP4 homolog [Tribolium castaneum]>gi|270016485|gb|EFA12931.1| hypothetical protein TcasGA2_TC010477 [Tribolium castaneum] 194750862 XM_001957713.1 248 2.41087e-124 Drosophila ananassae GF10569 (Dana\GF10569), mRNA K08827 PRPF4B serine/threonine-protein kinase PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K08827 Q13523 1338 7.3e-146 Serine/threonine-protein kinase PRP4 homolog OS=Homo sapiens GN=PRPF4B PE=1 SV=3 PF05445//PF07714//PF00069 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0670 U4/U6-associated splicing factor PRP4 Cluster-8309.26727 BF_2 67.00 1.94 1731 642938732 XP_966846.2 813 6.0e-84 PREDICTED: methionine synthase reductase [Tribolium castaneum] -- -- -- -- -- K00597 MTRR methionine synthase reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00597 Q498R1 684 2.2e-70 Methionine synthase reductase OS=Rattus norvegicus GN=Mtrr PE=2 SV=2 PF00175//PF08030//PF00667 Oxidoreductase NAD-binding domain//Ferric reductase NAD binding domain//FAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.26728 BF_2 39.95 1.43 1458 478250608 ENN71100.1 1368 2.2e-148 hypothetical protein YQE_12033, partial [Dendroctonus ponderosae] -- -- -- -- -- K02328 POLD2 DNA polymerase delta subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02328 Q9W088 829 2.9e-87 DNA polymerase delta small subunit OS=Drosophila melanogaster GN=CG12018 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG2732 DNA polymerase delta, regulatory subunit 55 Cluster-8309.26730 BF_2 4.00 0.62 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26731 BF_2 337.05 4.75 3258 642932825 XP_008197001.1 2058 4.9e-228 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 1083 2.3e-116 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019//PF00957 Gamma-glutamyltranspeptidase//Synaptobrevin GO:0006693//GO:0006749//GO:0006691//GO:0019530//GO:0016192 prostaglandin metabolic process//glutathione metabolic process//leukotriene metabolic process//taurine metabolic process//vesicle-mediated transport GO:0003840 gamma-glutamyltransferase activity GO:0016021 integral component of membrane KOG2410 Gamma-glutamyltransferase Cluster-8309.26732 BF_2 25.59 0.33 3491 91089189 XP_974407.1 2024 4.6e-224 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 1083 2.4e-116 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019 Gamma-glutamyltranspeptidase GO:0019530//GO:0006691//GO:0006749//GO:0006693 taurine metabolic process//leukotriene metabolic process//glutathione metabolic process//prostaglandin metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.26735 BF_2 159.22 2.53 2916 546682502 ERL92425.1 1115 9.7e-119 hypothetical protein D910_09739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3T8J9 203 2.3e-14 GON-4-like protein OS=Homo sapiens GN=GON4L PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26736 BF_2 5.07 0.50 708 270015041 EFA11489.1 391 2.1e-35 hypothetical protein TcasGA2_TC014202 [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 Q9V9S8 357 7.6e-33 Ferrochelatase, mitochondrial OS=Drosophila melanogaster GN=FeCh PE=2 SV=1 PF09117//PF00762 MiAMP1//Ferrochelatase GO:0015994//GO:0006783//GO:0006952//GO:0045926 chlorophyll metabolic process//heme biosynthetic process//defense response//negative regulation of growth GO:0004325 ferrochelatase activity -- -- KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26737 BF_2 27.76 2.46 759 478256641 ENN76823.1 351 9.8e-31 hypothetical protein YQE_06664, partial [Dendroctonus ponderosae]>gi|546685160|gb|ERL94687.1| hypothetical protein D910_11962 [Dendroctonus ponderosae] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 P22315 290 4.8e-25 Ferrochelatase, mitochondrial OS=Mus musculus GN=Fech PE=1 SV=2 PF00762 Ferrochelatase GO:0006783//GO:0015994 heme biosynthetic process//chlorophyll metabolic process GO:0004325 ferrochelatase activity -- -- KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26738 BF_2 296.17 16.63 1032 642910800 XP_008193416.1 984 5.3e-104 PREDICTED: ferrochelatase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 Q9V9S8 824 7.8e-87 Ferrochelatase, mitochondrial OS=Drosophila melanogaster GN=FeCh PE=2 SV=1 PF09117//PF00762 MiAMP1//Ferrochelatase GO:0045926//GO:0015994//GO:0006952//GO:0006783 negative regulation of growth//chlorophyll metabolic process//defense response//heme biosynthetic process GO:0004325 ferrochelatase activity -- -- KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26739 BF_2 322.03 1.27 10888 270000947 EEZ97394.1 648 5.1e-64 hypothetical protein TcasGA2_TC011220 [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 P10394 426 1.2e-39 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF13639//PF02861//PF01105//PF06988//PF04108//PF00762//PF08651//PF00209//PF05791 Ring finger domain//Clp amino terminal domain, pathogenicity island component//emp24/gp25L/p24 family/GOLD//NifT/FixU protein//Autophagy protein Apg17//Ferrochelatase//DASH complex subunit Duo1//Sodium:neurotransmitter symporter family//Bacillus haemolytic enterotoxin (HBL) GO:0006836//GO:0015994//GO:0006783//GO:0009399//GO:0009405//GO:0006810//GO:0006914//GO:0007067//GO:0006812//GO:0019538 neurotransmitter transport//chlorophyll metabolic process//heme biosynthetic process//nitrogen fixation//pathogenesis//transport//autophagy//mitotic nuclear division//cation transport//protein metabolic process GO:0004325//GO:0005515//GO:0005328//GO:0008270 ferrochelatase activity//protein binding//neurotransmitter:sodium symporter activity//zinc ion binding GO:0072686//GO:0016020//GO:0016021//GO:0042729 mitotic spindle//membrane//integral component of membrane//DASH complex KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26740 BF_2 47.00 0.70 3091 91076270 XP_967714.1 583 5.0e-57 PREDICTED: uncharacterized protein LOC656069 [Tribolium castaneum]>gi|270002519|gb|EEZ98966.1| hypothetical protein TcasGA2_TC004821 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26741 BF_2 141.11 0.56 10903 270000947 EEZ97394.1 627 1.4e-61 hypothetical protein TcasGA2_TC011220 [Tribolium castaneum] -- -- -- -- -- K01772 hemH, FECH ferrochelatase http://www.genome.jp/dbget-bin/www_bget?ko:K01772 P10394 439 3.6e-41 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF05791//PF00209//PF06009//PF00762//PF08651//PF04108//PF06988//PF10044//PF01105//PF13639 Bacillus haemolytic enterotoxin (HBL)//Sodium:neurotransmitter symporter family//Laminin Domain II//Ferrochelatase//DASH complex subunit Duo1//Autophagy protein Apg17//NifT/FixU protein//Retinal tissue protein//emp24/gp25L/p24 family/GOLD//Ring finger domain GO:0006351//GO:0006836//GO:0015994//GO:0007155//GO:0006783//GO:0009399//GO:0009405//GO:0006914//GO:0006810//GO:0007067//GO:0006812//GO:0007049 transcription, DNA-templated//neurotransmitter transport//chlorophyll metabolic process//cell adhesion//heme biosynthetic process//nitrogen fixation//pathogenesis//autophagy//transport//mitotic nuclear division//cation transport//cell cycle GO:0004325//GO:0005515//GO:0005328//GO:0008270 ferrochelatase activity//protein binding//neurotransmitter:sodium symporter activity//zinc ion binding GO:0072686//GO:0016020//GO:0070176//GO:0016021//GO:0042729 mitotic spindle//membrane//DRM complex//integral component of membrane//DASH complex KOG1321 Protoheme ferro-lyase (ferrochelatase) Cluster-8309.26743 BF_2 960.47 29.99 1627 189237343 XP_001813445.1 1160 3.3e-124 PREDICTED: uncharacterized protein LOC100142172 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26744 BF_2 6.00 3.77 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26745 BF_2 11.90 0.56 1171 91079286 XP_972784.1 634 2.3e-63 PREDICTED: syntaxin-17 [Tribolium castaneum]>gi|270004314|gb|EFA00762.1| hypothetical protein TcasGA2_TC003648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D0I4 166 1.8e-10 Syntaxin-17 OS=Mus musculus GN=Stx17 PE=1 SV=1 PF04728//PF05531//PF06009//PF05739//PF00804//PF00816//PF03462 Lipoprotein leucine-zipper//Nucleopolyhedrovirus P10 protein//Laminin Domain II//SNARE domain//Syntaxin//H-NS histone family//PCRF domain GO:0006415//GO:0006355//GO:0007155//GO:0006449 translational termination//regulation of transcription, DNA-templated//cell adhesion//regulation of translational termination GO:0003677//GO:0016149//GO:0005515 DNA binding//translation release factor activity, codon specific//protein binding GO:0005622//GO:0016020//GO:0005840//GO:0005737//GO:0018444//GO:0019867//GO:0019028 intracellular//membrane//ribosome//cytoplasm//translation release factor complex//outer membrane//viral capsid -- -- Cluster-8309.26746 BF_2 8.00 69.44 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26748 BF_2 140.89 1.10 5635 642914535 XP_008201718.1 2050 7.1e-227 PREDICTED: Hermansky-Pudlak syndrome 1 protein homolog isoform X1 [Tribolium castaneum] 701432439 XM_010006117.1 50 4.1147e-14 PREDICTED: Chaetura pelagica kelch-like family member 5 (KLHL5), transcript variant X3, mRNA K10442 KLHL1_4_5 kelch-like protein 1/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10442 Q96PQ7 872 1.2e-91 Kelch-like protein 5 OS=Homo sapiens GN=KLHL5 PE=2 SV=3 PF07646//PF00651//PF10576//PF01344//PF03931 Kelch motif//BTB/POZ domain//Iron-sulfur binding domain of endonuclease III//Kelch motif//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0051539//GO:0005515 4 iron, 4 sulfur cluster binding//protein binding -- -- -- -- Cluster-8309.26753 BF_2 780.65 20.66 1868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26755 BF_2 1213.32 9.91 5411 642936846 XP_008197874.1 4246 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase listerin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1C231 1009 1.4e-107 E3 ubiquitin-protein ligase listerin OS=Gallus gallus GN=LTN1 PE=3 SV=1 PF12861//PF13639//PF00097//PF12906//PF12678//PF00628//PF05225//PF07022//PF00130 Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-H2 zinc finger//PHD-finger//helix-turn-helix, Psq domain//Bacteriophage CI repressor helix-turn-helix domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0016567//GO:0045892//GO:0035556 protein ubiquitination//negative regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0005515//GO:0004842//GO:0008270//GO:0046872 DNA binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0005680 anaphase-promoting complex KOG0803 Predicted E3 ubiquitin ligase Cluster-8309.26756 BF_2 446.00 5.13 3925 642916707 XP_008192271.1 5016 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C6B8 862 1.2e-90 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Rattus norvegicus GN=Svep1 PE=1 SV=1 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.26758 BF_2 316.79 7.16 2137 91089541 XP_971419.1 817 2.5e-84 PREDICTED: protein canopy 4 [Tribolium castaneum]>gi|270012595|gb|EFA09043.1| hypothetical protein TcasGA2_TC006756 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2L6K8 521 2.2e-51 Protein canopy 4 OS=Danio rerio GN=cnpy4 PE=2 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- KOG4052 Uncharacterized conserved protein Cluster-8309.26760 BF_2 118.03 2.47 2289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26761 BF_2 173.61 1.90 4118 91078812 XP_970578.1 598 1.2e-58 PREDICTED: phytanoyl-CoA dioxygenase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270004117|gb|EFA00565.1| hypothetical protein TcasGA2_TC003435 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRE7 351 2.2e-31 Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Homo sapiens GN=PHYHD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.26762 BF_2 1603.00 51.39 1592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26763 BF_2 16.00 0.82 1105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26766 BF_2 15.00 1.31 765 571524111 XP_006562788.1 196 9.3e-13 PREDICTED: uncharacterized protein LOC724604 [Apis mellifera] 642918390 XM_008201903.1 49 1.93337e-14 PREDICTED: Tribolium castaneum zinc finger protein 271-like (LOC656007), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P52737 174 1.4e-11 Zinc finger protein 136 OS=Homo sapiens GN=ZNF136 PE=1 SV=1 PF00096//PF13465//PF15926//PF01780//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//E3 ubiquitin-protein ligase RNF220//Ribosomal L37ae protein family//BED zinc finger//C2H2-type zinc finger GO:0016567//GO:0006412//GO:0090263//GO:0042254 protein ubiquitination//translation//positive regulation of canonical Wnt signaling pathway//ribosome biogenesis GO:0003677//GO:0046872//GO:0003735 DNA binding//metal ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.26769 BF_2 71.45 0.65 4857 478257240 ENN77403.1 2157 2.4e-239 hypothetical protein YQE_06228, partial [Dendroctonus ponderosae] 768451728 XM_011569773.1 111 4.36166e-48 PREDICTED: Plutella xylostella GTPase-activating protein-like (LOC105397755), partial mRNA K12380 RASA3 Ras GTPase-activating protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12380 P48423 1378 2.1e-150 GTPase-activating protein OS=Drosophila melanogaster GN=RasGAP1 PE=1 SV=2 PF00779//PF00616//PF00168 BTK motif//GTPase-activator protein for Ras-like GTPase//C2 domain GO:0043087//GO:0035556 regulation of GTPase activity//intracellular signal transduction GO:0005515 protein binding -- -- KOG2059 Ras GTPase-activating protein Cluster-8309.26772 BF_2 12.77 0.36 1752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26773 BF_2 62.68 1.11 2648 642912820 XP_008201266.1 496 5.3e-47 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 289 2.2e-24 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 PF01825 GPCR proteolysis site, GPS, motif -- -- -- -- GO:0016020 membrane KOG4320 Uncharacterized conserved protein Cluster-8309.26774 BF_2 54.58 0.95 2692 642912820 XP_008201266.1 496 5.4e-47 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 289 2.2e-24 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-8309.26775 BF_2 17.36 0.47 1818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26779 BF_2 20.23 0.50 1973 642919618 XP_008191942.1 572 6.0e-56 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 76 5.01646e-29 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q9DDA9 294 4.3e-25 Protein kinase C and casein kinase substrate in neurons protein 2 OS=Xenopus laevis GN=pacsin2 PE=2 SV=1 PF15460//PF01786 Something about silencing, SAS, complex subunit 4//Alternative oxidase GO:0016573//GO:0006118//GO:0055114 histone acetylation//obsolete electron transport//oxidation-reduction process GO:0009916 alternative oxidase activity -- -- KOG2856 Adaptor protein PACSIN Cluster-8309.2678 BF_2 31.00 2.90 734 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26784 BF_2 11.00 0.32 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26785 BF_2 28.00 2.13 836 184198734 ACC76803.1 697 8.2e-71 Lit v 3 allergen myosin light chain [Litopenaeus vannamei] 184198733 EU449515.1 263 2.31541e-133 Litopenaeus vannamei Lit v 3 allergen myosin light chain mRNA, complete cds K10351 MYL2 myosin regulatory light chain 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10351 Q1HPS0 502 1.4e-49 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF01342//PF13499//PF13833//PF13405//PF00036//PF13202 SAND domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//EF hand -- -- GO:0005509//GO:0003677 calcium ion binding//DNA binding -- -- -- -- Cluster-8309.26786 BF_2 2.00 0.86 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26787 BF_2 402.18 3.25 5467 91086191 XP_971352.1 1528 2.3e-166 PREDICTED: WD repeat-containing protein 92 [Tribolium castaneum]>gi|270010235|gb|EFA06683.1| hypothetical protein TcasGA2_TC009613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29RZ9 1178 3.7e-127 WD repeat-containing protein 92 OS=Bos taurus GN=WDR92 PE=2 SV=1 PF00400//PF02391//PF10741 WD domain, G-beta repeat//MoaE protein//Type II secretion system (T2SS), protein M subtype b GO:0006858//GO:0006777 extracellular transport//Mo-molybdopterin cofactor biosynthetic process GO:0005515 protein binding -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.26792 BF_2 1.32 0.34 449 282720995 NP_001164248.1 369 4.7e-33 cytochrome P450 9Z4 [Tribolium castaneum]>gi|270012794|gb|EFA09242.1| cytochrome P450 9Z4 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 263 3.8e-22 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005506//GO:0004497//GO:0020037//GO:0016705//GO:0009055 iron ion binding//monooxygenase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- -- -- Cluster-8309.26794 BF_2 16.62 0.68 1306 189240985 XP_001808932.1 867 2.5e-90 PREDICTED: probable cytosolic Fe-S cluster assembly factor CPIJ010948 [Tribolium castaneum]>gi|270012992|gb|EFA09440.1| hypothetical protein TcasGA2_TC010652 [Tribolium castaneum] 462325677 APGK01041744.1 51 2.59784e-15 Dendroctonus ponderosae Seq01041754, whole genome shotgun sequence -- -- -- -- B4MUM8 561 3.1e-56 Probable cytosolic Fe-S cluster assembly factor GK14772 OS=Drosophila willistoni GN=GK14772 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2439 Nuclear architecture related protein Cluster-8309.26795 BF_2 201.04 1.23 7107 642916946 XP_008199566.1 487 1.6e-45 PREDICTED: FGFR1 oncogene partner [Tribolium castaneum] 242023379 XM_002432067.1 93 6.48549e-38 Pediculus humanus corporis mitochondrial import inner membrane translocase subunit TIM13, putative, mRNA K17781 TIM13 mitochondrial import inner membrane translocase subunit TIM13 http://www.genome.jp/dbget-bin/www_bget?ko:K17781 Q8AVK1 314 7.4e-27 Mitochondrial import inner membrane translocase subunit Tim13-B OS=Xenopus laevis GN=timm13-b PE=3 SV=1 PF09398//PF01468//PF16045 FOP N terminal dimerisation domain//GA module//LisH GO:0009405//GO:0034453 pathogenesis//microtubule anchoring GO:0005515 protein binding GO:0005815 microtubule organizing center KOG1733 Mitochondrial import inner membrane translocase, subunit TIM13 Cluster-8309.26796 BF_2 13.00 1.34 692 642099317 CDQ77565.1 170 8.7e-10 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26797 BF_2 27.67 0.34 3698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26798 BF_2 11.87 0.71 982 270010105 EFA06553.1 766 9.6e-79 hypothetical protein TcasGA2_TC009462 [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 356 1.4e-32 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF08477//PF00071//PF00025//PF04042 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family//DNA polymerase alpha/epsilon subunit B GO:0007264//GO:0006260 small GTPase mediated signal transduction//DNA replication GO:0003887//GO:0003677//GO:0005525 DNA-directed DNA polymerase activity//DNA binding//GTP binding GO:0042575 DNA polymerase complex KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.26799 BF_2 162.07 8.62 1074 91085709 XP_972846.1 843 1.2e-87 PREDICTED: ras-related protein RABF2b [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 383 1.1e-35 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF04670//PF00025//PF00071//PF01637//PF01926//PF03193//PF08477 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//Archaeal ATPase//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.26800 BF_2 45.88 0.38 5278 270007560 EFA04008.1 685 1.3e-68 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 408 6.9e-38 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26803 BF_2 151.00 2.73 2600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26807 BF_2 299.92 10.67 1463 91079170 XP_967650.1 875 3.3e-91 PREDICTED: viral IAP-associated factor homolog [Tribolium castaneum]>gi|270004241|gb|EFA00689.1| hypothetical protein TcasGA2_TC003566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MR62 659 1.5e-67 Viral IAP-associated factor homolog OS=Drosophila melanogaster GN=viaf PE=1 SV=1 PF00445//PF04104 Ribonuclease T2 family//Eukaryotic and archaeal DNA primase, large subunit GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0033897//GO:0003896//GO:0003723 ribonuclease T2 activity//DNA primase activity//RNA binding GO:0005730//GO:0005657 nucleolus//replication fork KOG3170 Conserved phosducin-like protein Cluster-8309.26811 BF_2 603.00 9.27 3009 91090594 XP_972814.1 2987 0.0e+00 PREDICTED: ATP-binding cassette sub-family F member 3 [Tribolium castaneum]>gi|270013337|gb|EFA09785.1| hypothetical protein TcasGA2_TC011927 [Tribolium castaneum] 755851249 XM_005175430.2 126 1.23383e-56 PREDICTED: Musca domestica ATP-binding cassette sub-family F member 3 (LOC101901338), mRNA K06158 ABCF3 ATP-binding cassette, subfamily F, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06158 Q8K268 2195 2.4e-245 ATP-binding cassette sub-family F member 3 OS=Mus musculus GN=Abcf3 PE=1 SV=1 PF00004//PF01926//PF13304//PF08477//PF00910//PF02601//PF10662//PF03205//PF02367//PF00005//PF03266//PF03193 ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//RNA helicase//Exonuclease VII, large subunit//Ethanolamine utilisation - propanediol utilisation//Molybdopterin guanine dinucleotide synthesis protein B//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//NTPase//Protein of unknown function, DUF258 GO:0006308//GO:0007264//GO:0006777//GO:0002949//GO:0006200//GO:0006576 DNA catabolic process//small GTPase mediated signal transduction//Mo-molybdopterin cofactor biosynthetic process//tRNA threonylcarbamoyladenosine modification//obsolete ATP catabolic process//cellular biogenic amine metabolic process GO:0003724//GO:0016887//GO:0005525//GO:0003924//GO:0008855//GO:0098519//GO:0005524//GO:0003723 RNA helicase activity//ATPase activity//GTP binding//GTPase activity//exodeoxyribonuclease VII activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//RNA binding GO:0009318 exodeoxyribonuclease VII complex KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b Cluster-8309.26812 BF_2 291.65 2.90 4498 642931322 XP_008196531.1 3232 0.0e+00 PREDICTED: kinase suppressor of Ras 2 isoform X2 [Tribolium castaneum] 642931321 XM_008198309.1 207 1.73755e-101 PREDICTED: Tribolium castaneum kinase suppressor of Ras 2 (LOC661985), transcript variant X2, mRNA K18529 KSR2 kinase suppressor of Ras 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18529 Q6VAB6 900 5.2e-95 Kinase suppressor of Ras 2 OS=Homo sapiens GN=KSR2 PE=1 SV=2 PF00069//PF06293//PF07714//PF07649//PF00130//PF01146 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Caveolin GO:0006468//GO:0070836//GO:0055114//GO:0035556 protein phosphorylation//caveola assembly//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0016773//GO:0004672//GO:0047134 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity GO:0016020 membrane KOG0193 Serine/threonine protein kinase RAF Cluster-8309.26813 BF_2 874.00 30.91 1470 91095001 XP_969305.1 1437 2.2e-156 PREDICTED: E3 ubiquitin-protein ligase RNF13 [Tribolium castaneum]>gi|270015391|gb|EFA11839.1| hypothetical protein TcasGA2_TC002100 [Tribolium castaneum] -- -- -- -- -- K15692 RNF13, RZF E3 ubiquitin-protein ligase RNF13 http://www.genome.jp/dbget-bin/www_bget?ko:K15692 Q5RCV8 568 5.4e-57 E3 ubiquitin-protein ligase RNF13 OS=Pongo abelii GN=RNF13 PE=2 SV=1 PF17122//PF00097//PF12906//PF12678//PF17123//PF00628//PF14634//PF11789//PF12861//PF13639 Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-H2 zinc finger//RING-like zinc finger//PHD-finger//zinc-RING finger domain//Zinc-finger of the MIZ type in Nse subunit//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.26814 BF_2 54.00 15.33 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26816 BF_2 149.45 5.33 1460 724970788 XP_010357705.1 656 8.1e-66 PREDICTED: myosin light chain alkali-like [Rhinopithecus roxellana] 724970787 XM_010359403.1 392 0 PREDICTED: Rhinopithecus roxellana myosin light chain alkali-like (LOC104659290), mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24756 393 1.0e-36 Myosin light chain alkali OS=Drosophila virilis GN=Mlc1 PE=3 SV=1 PF13499//PF00036//PF13405 EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.26819 BF_2 6.32 0.40 947 189234762 XP_001814757.1 959 3.9e-101 PREDICTED: transmembrane emp24 domain-containing protein eca [Tribolium castaneum]>gi|270001537|gb|EEZ97984.1| hypothetical protein TcasGA2_TC000379 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4GMC3 885 6.0e-94 Transmembrane emp24 domain-containing protein eca OS=Drosophila persimilis GN=eca PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1690 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.26820 BF_2 245.00 8.97 1430 91090790 XP_970204.1 1502 6.3e-164 PREDICTED: transmembrane protein 115 [Tribolium castaneum]>gi|270013973|gb|EFA10421.1| hypothetical protein TcasGA2_TC012661 [Tribolium castaneum] 665805825 XM_008552904.1 76 3.61092e-29 PREDICTED: Microplitis demolitor transmembrane protein 115 (LOC103573716), mRNA -- -- -- -- Q9WUH1 715 4.7e-74 Transmembrane protein 115 OS=Mus musculus GN=Tmem115 PE=1 SV=1 PF08551//PF01694 Eukaryotic integral membrane protein (DUF1751)//Rhomboid family GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2890 Predicted membrane protein Cluster-8309.26821 BF_2 1885.62 50.86 1838 546676408 ERL87426.1 767 1.4e-78 hypothetical protein D910_04820 [Dendroctonus ponderosae] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8VHB5 330 2.7e-29 Carbonic anhydrase 9 OS=Mus musculus GN=Ca9 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26822 BF_2 22.88 0.49 2221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03248//PF00584 Rer1 family//SecE/Sec61-gamma subunits of protein translocation complex GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.26823 BF_2 3.00 1.68 358 829084927 XP_012648878.1 442 1.3e-41 uncharacterized protein [Babesia microti strain RI]>gi|399217583|emb|CCF74470.1| unnamed protein product [Babesia microti strain RI] 308512649 HM449082.1 215 4.52403e-107 Eriocheir sinensis ubiquitin b mRNA, complete cds K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH07 433 5.9e-42 Ubiquitin-60S ribosomal protein L40 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=uep1 PE=1 SV=1 PF00240//PF01020 Ubiquitin family//Ribosomal L40e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-8309.26824 BF_2 38.00 7.07 512 617378910 XP_007545873.1 393 8.9e-36 PREDICTED: polyubiquitin-B isoform X4 [Poecilia formosa] 260766534 GQ903729.1 508 0 Scylla paramamosain ubiquitin mRNA, complete cds K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 Q63429 385 3.1e-36 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560//PF01599 Ubiquitin family//Ubiquitin-like domain//Ribosomal protein S27a GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.26826 BF_2 5.90 0.33 1025 642929994 XP_008196057.1 217 4.6e-15 PREDICTED: uncharacterized protein LOC664557 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26829 BF_2 11.50 0.46 1338 91094063 XP_969813.1 573 3.1e-56 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016180|gb|EFA12628.1| cytochrome P450 6BR2 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 401 1.1e-37 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF15014//PF15681//PF00067 Ceroid-lipofuscinosis neuronal protein 5//Lymphocyte activation family X//Cytochrome P450 GO:0051249//GO:0006955//GO:0055114//GO:0022008 regulation of lymphocyte activation//immune response//oxidation-reduction process//neurogenesis GO:0005488//GO:0020037//GO:0005506//GO:0016705//GO:0016491 binding//heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity GO:0005764 lysosome -- -- Cluster-8309.26830 BF_2 5.00 0.55 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08126 Propeptide_C25 GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.26831 BF_2 464.00 6.26 3387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04810 Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.26833 BF_2 35.78 0.40 4069 642929105 XP_001810643.2 647 2.5e-64 PREDICTED: uncharacterized protein LOC100142047 [Tribolium castaneum] -- -- -- -- -- K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 Q63ZW7 319 1.1e-27 InaD-like protein OS=Mus musculus GN=Inadl PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.26837 BF_2 593.63 2.60 9829 642929105 XP_001810643.2 3947 0.0e+00 PREDICTED: uncharacterized protein LOC100142047 [Tribolium castaneum] 642929104 XM_001810591.2 336 7.4206e-173 PREDICTED: Tribolium castaneum uncharacterized LOC100142047 (LOC100142047), mRNA K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 Q9NB04 802 2.6e-83 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF05965//PF13180//PF00595 F/Y rich C-terminus//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding GO:0005634 nucleus KOG3528 FOG: PDZ domain Cluster-8309.26838 BF_2 44.54 2.55 1017 642929105 XP_001810643.2 611 9.3e-61 PREDICTED: uncharacterized protein LOC100142047 [Tribolium castaneum] -- -- -- -- -- K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 O75970 285 2.4e-24 Multiple PDZ domain protein OS=Homo sapiens GN=MPDZ PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.26841 BF_2 113.00 3.04 1841 642936415 XP_972550.2 310 1.4e-25 PREDICTED: suppression of tumorigenicity 5 protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0006570//GO:0055114 obsolete electron transport//tyrosine metabolic process//oxidation-reduction process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.26844 BF_2 3.00 1.64 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26845 BF_2 24.21 1.36 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26848 BF_2 67.63 1.36 2367 642922580 XP_008193235.1 1409 6.4e-153 PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922582|ref|XP_008193236.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922584|ref|XP_008193237.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922586|ref|XP_008193238.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34447 225 5.1e-17 Uncharacterized protein F54F2.2, isoform a OS=Caenorhabditis elegans GN=F54F2.2/F54F2.3/F54F2.4 PE=3 SV=2 PF05405 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG0956 PHD finger protein AF10 Cluster-8309.26851 BF_2 18.55 0.57 1660 332374670 AEE62476.1 724 1.2e-73 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9LZG0 383 1.7e-35 Adenosine kinase 2 OS=Arabidopsis thaliana GN=ADK2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.26852 BF_2 100.84 1.56 2996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26854 BF_2 1774.37 13.69 5709 642928646 XP_008199719.1 1825 8.9e-201 PREDICTED: oxysterol-binding protein-related protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZF3 1247 3.9e-135 Oxysterol-binding protein-related protein 6 OS=Homo sapiens GN=OSBPL6 PE=1 SV=1 PF03623 Focal adhesion targeting region GO:0007172//GO:0006468//GO:0007165 signal complex assembly//protein phosphorylation//signal transduction GO:0004871//GO:0004713 signal transducer activity//protein tyrosine kinase activity GO:0005925 focal adhesion -- -- Cluster-8309.26855 BF_2 48.63 0.48 4547 642917767 XP_008191359.1 927 9.5e-97 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 371 1.2e-33 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF07992//PF05834//PF00732//PF02558//PF02254//PF05199 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//Ketopantoate reductase PanE/ApbA//TrkA-N domain//GMC oxidoreductase GO:0015940//GO:0044710//GO:0006813//GO:0016117//GO:0055114 pantothenate biosynthetic process//single-organism metabolic process//potassium ion transport//carotenoid biosynthetic process//oxidation-reduction process GO:0016614//GO:0016705//GO:0016491//GO:0050660//GO:0008677 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity -- -- -- -- Cluster-8309.26859 BF_2 129.88 4.94 1386 91087295 XP_975560.1 596 7.0e-59 PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum]>gi|642929763|ref|XP_008195964.1| PREDICTED: MIP18 family protein CG30152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V968 522 1.1e-51 MIP18 family protein CG30152 OS=Drosophila melanogaster GN=CG30152 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3381 Uncharacterized conserved protein Cluster-8309.26860 BF_2 1619.51 13.65 5250 817211042 XP_012281638.1 3987 0.0e+00 PREDICTED: catenin alpha [Orussus abietinus]>gi|817211044|ref|XP_012281639.1| PREDICTED: catenin alpha [Orussus abietinus]>gi|817211046|ref|XP_012281640.1| PREDICTED: catenin alpha [Orussus abietinus] 642911688 XM_008202480.1 947 0 PREDICTED: Tribolium castaneum catenin alpha (LOC658703), transcript variant X3, mRNA K05691 CTNNA catenin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05691 P35220 3588 0.0e+00 Catenin alpha OS=Drosophila melanogaster GN=alpha-Cat PE=1 SV=2 PF00328//PF00639//PF03223//PF01044//PF03938//PF08919//PF00435//PF01608//PF04632 Histidine phosphatase superfamily (branch 2)//PPIC-type PPIASE domain//V-ATPase subunit C//Vinculin family//Outer membrane protein (OmpH-like)//F-actin binding//Spectrin repeat//I/LWEQ domain//Fusaric acid resistance protein family GO:0019497//GO:0006810//GO:0006468//GO:0015992//GO:0015991//GO:0006771//GO:0007155 hexachlorocyclohexane metabolic process//transport//protein phosphorylation//proton transport//ATP hydrolysis coupled proton transport//riboflavin metabolic process//cell adhesion GO:0005524//GO:0003779//GO:0015078//GO:0003993//GO:0051015//GO:0051082//GO:0004715//GO:0005515//GO:0016853 ATP binding//actin binding//hydrogen ion transmembrane transporter activity//acid phosphatase activity//actin filament binding//unfolded protein binding//non-membrane spanning protein tyrosine kinase activity//protein binding//isomerase activity GO:0033180//GO:0005886 proton-transporting V-type ATPase, V1 domain//plasma membrane KOG3681 Alpha-catenin Cluster-8309.26861 BF_2 386.23 19.31 1124 91084595 XP_974201.1 812 5.1e-84 PREDICTED: 39S ribosomal protein L44, mitochondrial [Tribolium castaneum]>gi|270008900|gb|EFA05348.1| hypothetical protein TcasGA2_TC015512 [Tribolium castaneum] -- -- -- -- -- K17425 MRPL44 large subunit ribosomal protein L44 http://www.genome.jp/dbget-bin/www_bget?ko:K17425 Q2KIS2 377 5.8e-35 39S ribosomal protein L44, mitochondrial OS=Bos taurus GN=MRPL44 PE=2 SV=1 PF14622 Ribonuclease-III-like GO:0006396//GO:0051252 RNA processing//regulation of RNA metabolic process GO:0004525//GO:0003723 ribonuclease III activity//RNA binding -- -- KOG3769 Ribonuclease III domain proteins Cluster-8309.26864 BF_2 222.41 22.81 695 478254757 ENN74994.1 180 6.0e-11 hypothetical protein YQE_08451, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PSY2 164 1.8e-10 UPF0729 protein AGAP000931 OS=Anopheles gambiae GN=AGAP000931 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26866 BF_2 306.40 7.59 1977 478252561 ENN72974.1 1491 1.7e-162 hypothetical protein YQE_10405, partial [Dendroctonus ponderosae] 827562517 XM_004933295.2 39 1.85986e-08 PREDICTED: Bombyx mori probable chitinase 2 (LOC101744821), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 1062 3.8e-114 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.26869 BF_2 104.90 2.66 1938 642923549 XP_008193554.1 1209 8.1e-130 PREDICTED: zinc finger and SCAN domain-containing protein 2-like isoform X2 [Tribolium castaneum] 642923548 XM_008195332.1 36 8.4793e-07 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5VIY5 333 1.3e-29 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF07776//PF02178//PF00096//PF13465//PF00960//PF00982 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//AT hook motif//Zinc finger, C2H2 type//Zinc-finger double domain//Neocarzinostatin family//Glycosyltransferase family 20 GO:0006952//GO:0005992 defense response//trehalose biosynthetic process GO:0046872//GO:0003824//GO:0008270//GO:0003677 metal ion binding//catalytic activity//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.26870 BF_2 193.00 8.47 1240 392499121 AFM75821.1 535 7.4e-52 myosin light chain 2 [Procambarus clarkii] 392499120 JX013934.1 281 3.42893e-143 Procambarus clarkii myosin light chain 2 mRNA, complete cds K12757 MYL12 myosin regulatory light chain 12 http://www.genome.jp/dbget-bin/www_bget?ko:K12757 Q1HPS0 372 2.4e-34 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13202//PF03121//PF13405//PF00036//PF13833//PF13499 EF hand//Herpesviridae UL52/UL70 DNA primase//EF-hand domain//EF hand//EF-hand domain pair//EF-hand domain pair GO:0006269//GO:0006260//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated GO:0003896//GO:0005509 DNA primase activity//calcium ion binding GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.26871 BF_2 24.00 6.27 447 270013462 EFA09910.1 287 1.5e-23 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26872 BF_2 10.00 1.74 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26873 BF_2 453.10 15.08 1544 546682476 ERL92399.1 1061 9.4e-113 hypothetical protein D910_09713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 589 2.1e-59 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.26875 BF_2 1.59 0.46 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26876 BF_2 31.33 1.39 1233 478264795 ENN82329.1 823 3.0e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 5.2e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.26877 BF_2 566.82 28.57 1117 189233768 XP_001814337.1 800 1.2e-82 PREDICTED: protein jagunal [Tribolium castaneum]>gi|270015057|gb|EFA11505.1| hypothetical protein TcasGA2_TC014219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q297K8 581 1.3e-58 Protein jagunal OS=Drosophila pseudoobscura pseudoobscura GN=jagn PE=3 SV=1 PF07086 Jagunal, ER re-organisation during oogenesis GO:0007029 endoplasmic reticulum organization -- -- GO:0005789 endoplasmic reticulum membrane KOG4054 Uncharacterized conserved protein Cluster-8309.26878 BF_2 310.38 6.35 2332 546683161 ERL93009.1 929 2.9e-97 hypothetical protein D910_10311 [Dendroctonus ponderosae] -- -- -- -- -- K04729 MYD88 myeloid differentiation primary response protein MyD88 http://www.genome.jp/dbget-bin/www_bget?ko:K04729 A8QMS7 316 1.4e-27 Myeloid differentiation primary response protein MyD88 OS=Takifugu rubripes GN=myd88 PE=2 SV=1 PF13676//PF01582//PF00531 TIR domain//TIR domain//Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.26880 BF_2 268.89 5.82 2219 270014769 EFA11217.1 676 5.9e-68 hypothetical protein TcasGA2_TC005181 [Tribolium castaneum] 158299715 XM_319761.3 56 7.41712e-18 Anopheles gambiae str. PEST AGAP009016-PA (AgaP_AGAP009016) mRNA, complete cds K16673 LIX1L LIX1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K16673 Q8IVB5 542 8.4e-54 LIX1-like protein OS=Homo sapiens GN=LIX1L PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26884 BF_2 260.10 5.11 2418 642929003 XP_973340.3 1849 6.2e-204 PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|642929005|ref|XP_008195651.1| PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum] 642929004 XM_008197429.1 222 4.25809e-110 PREDICTED: Tribolium castaneum alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC662130), transcript variant X2, mRNA K00726 MGAT1 alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00726 P27808 1188 1.1e-128 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat1 PE=2 SV=1 PF03071 GNT-I family GO:0006486 protein glycosylation GO:0008375 acetylglucosaminyltransferase activity -- -- KOG1413 N-acetylglucosaminyltransferase I Cluster-8309.26886 BF_2 19.00 0.79 1289 642923174 XP_008193640.1 910 2.5e-95 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- K10402 KIF20 kinesin family member 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10402 O95235 401 1.1e-37 Kinesin-like protein KIF20A OS=Homo sapiens GN=KIF20A PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0247 Kinesin-like protein Cluster-8309.26887 BF_2 730.01 10.83 3106 642930988 XP_008196167.1 1409 8.4e-153 PREDICTED: multiple inositol polyphosphate phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K03103 MINPP1 multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K03103 Q5R890 341 2.4e-30 Multiple inositol polyphosphate phosphatase 1 OS=Pongo abelii GN=MINPP1 PE=2 SV=1 PF00328//PF01529 Histidine phosphatase superfamily (branch 2)//DHHC palmitoyltransferase GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0008270 acid phosphatase activity//zinc ion binding -- -- KOG1382 Multiple inositol polyphosphate phosphatase Cluster-8309.26888 BF_2 633.00 22.65 1456 332375995 AEE63138.1 541 1.7e-52 unknown [Dendroctonus ponderosae]>gi|546680455|gb|ERL90721.1| hypothetical protein D910_08069 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6NYP0 324 1.0e-28 Transmembrane protein 208 OS=Danio rerio GN=tmem208 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3269 Predicted membrane protein Cluster-8309.26889 BF_2 710.00 12.61 2642 642913655 XP_008201106.1 3667 0.0e+00 PREDICTED: nuclear cap-binding protein subunit 1 [Tribolium castaneum] 665389593 NM_080011.3 260 3.50065e-131 Drosophila melanogaster cap binding protein 80 (Cbp80), transcript variant B, mRNA K12882 NCBP1, CBP80 nuclear cap-binding protein subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12882 Q7K4N3 3195 0.0e+00 Nuclear cap-binding protein subunit 1 OS=Drosophila melanogaster GN=Cbp80 PE=1 SV=1 PF00558//PF02854//PF09088//PF09090 Vpu protein//MIF4G domain//MIF4G like//MIF4G like GO:0006812//GO:0032801//GO:0016070//GO:0019076 cation transport//receptor catabolic process//RNA metabolic process//viral release from host cell GO:0003723//GO:0005261//GO:0005515 RNA binding//cation channel activity//protein binding GO:0033644 host cell membrane KOG1104 Nuclear cap-binding complex, subunit NCBP1/CBP80 Cluster-8309.26891 BF_2 79.20 0.91 3945 91094219 XP_973249.1 584 4.9e-57 PREDICTED: uncharacterized protein C9orf85 homolog isoform X2 [Tribolium castaneum]>gi|270016216|gb|EFA12662.1| hypothetical protein TcasGA2_TC002245 [Tribolium castaneum] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q5TZ51 379 1.2e-34 Protein Mpv17 OS=Danio rerio GN=mpv17 PE=2 SV=1 PF04117//PF01990 Mpv17 / PMP22 family//ATP synthase (F/14-kDa) subunit GO:0034220 ion transmembrane transport -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.26896 BF_2 1458.05 17.27 3818 91081335 XP_967042.1 5400 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X2 [Tribolium castaneum]>gi|270005182|gb|EFA01630.1| hypothetical protein TcasGA2_TC007200 [Tribolium castaneum] 820837636 XM_012494483.1 538 0 PREDICTED: Apis florea probable phosphorylase b kinase regulatory subunit alpha (LOC100865608), transcript variant X3, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 4434 0.0e+00 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 PF07525 SOCS box GO:0005975//GO:0035556//GO:0005977 carbohydrate metabolic process//intracellular signal transduction//glycogen metabolic process GO:0004553//GO:0005516 hydrolase activity, hydrolyzing O-glycosyl compounds//calmodulin binding -- -- KOG3635 Phosphorylase kinase Cluster-8309.26898 BF_2 42.00 4.32 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12125 D domain of beta-TrCP -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.26900 BF_2 285.84 1.01 12079 546675663 ERL86811.1 3043 0.0e+00 hypothetical protein D910_04215 [Dendroctonus ponderosae] -- -- -- -- -- K10848 ERCC4, XPF DNA excision repair protein ERCC-4 http://www.genome.jp/dbget-bin/www_bget?ko:K10848 P15215 2067 6.7e-230 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 PF06008//PF00927//PF02732//PF08496 Laminin Domain I//Transglutaminase family, C-terminal ig like domain//ERCC4 domain//Peptidase family S49 N-terminal GO:0018149//GO:0007165//GO:0030334//GO:0045995//GO:0030155 peptide cross-linking//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of cell adhesion GO:0003677//GO:0004252//GO:0004518//GO:0005102//GO:0003810 DNA binding//serine-type endopeptidase activity//nuclease activity//receptor binding//protein-glutamine gamma-glutamyltransferase activity GO:0005886 plasma membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.26902 BF_2 4.00 0.42 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26906 BF_2 499.28 9.49 2489 332377021 AEE63650.1 2446 3.8e-273 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01303 APEH acylaminoacyl-peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01303 P13676 1008 8.7e-108 Acylamino-acid-releasing enzyme OS=Rattus norvegicus GN=Apeh PE=1 SV=1 PF00326//PF07859//PF02129 Prolyl oligopeptidase family//alpha/beta hydrolase fold//X-Pro dipeptidyl-peptidase (S15 family) GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.26907 BF_2 40.03 0.59 3121 642929021 XP_008195658.1 1369 3.7e-148 PREDICTED: RNA-binding protein Nova-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14944 NOVA RNA-binding protein Nova http://www.genome.jp/dbget-bin/www_bget?ko:K14944 Q2PFW9 486 3.7e-47 RNA-binding protein Nova-1 OS=Macaca fascicularis GN=NOVA1 PE=2 SV=1 PF13014//PF13184//PF00013//PF07650 KH domain//NusA-like KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2191 RNA-binding protein NOVA1/PASILLA and related KH domain proteins Cluster-8309.26908 BF_2 32.00 0.77 2015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26910 BF_2 98.00 5.08 1094 91095123 XP_970890.1 603 8.5e-60 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 421 4.4e-40 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01370//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.26911 BF_2 839.25 22.00 1883 91076690 XP_971724.1 1361 1.9e-147 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 126 7.67183e-57 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 A2APY7 818 7.1e-86 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Mus musculus GN=Ndufaf5 PE=2 SV=1 PF05175//PF08241//PF03492//PF01209 Methyltransferase small domain//Methyltransferase domain//SAM dependent carboxyl methyltransferase//ubiE/COQ5 methyltransferase family GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG2940 Predicted methyltransferase Cluster-8309.26912 BF_2 261.13 1.40 8111 642935644 XP_008198096.1 4262 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X5 [Tribolium castaneum] 642935647 XM_008199876.1 244 8.49522e-122 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.4e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00595//PF00620//PF08718 PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//Glycolipid transfer protein (GLTP) GO:0046836//GO:0007165 glycolipid transport//signal transduction GO:0005515//GO:0017089//GO:0051861 protein binding//glycolipid transporter activity//glycolipid binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.26913 BF_2 51.40 0.48 4757 270013936 EFA10384.1 2301 4.7e-256 hypothetical protein TcasGA2_TC012615 [Tribolium castaneum] 642935647 XM_008199876.1 190 5.18431e-92 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 726 8.3e-75 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.26914 BF_2 378.44 16.09 1271 478257005 ENN77169.1 372 6.0e-33 hypothetical protein YQE_06307, partial [Dendroctonus ponderosae]>gi|546683319|gb|ERL93146.1| hypothetical protein D910_10445 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00003//PF00520 7 transmembrane sweet-taste receptor of 3 GCPR//Ion transport protein GO:0006811//GO:0055085//GO:0007186 ion transport//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0005216 G-protein coupled receptor activity//ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.26915 BF_2 455.29 8.71 2474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26917 BF_2 23.11 0.43 2519 861626561 KMQ88832.1 210 7.3e-14 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26919 BF_2 14.00 0.52 1408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2692 BF_2 4.71 0.31 932 189241899 XP_967370.2 347 3.5e-30 PREDICTED: TP53-regulated inhibitor of apoptosis 1-like [Tribolium castaneum] -- -- -- -- -- K17968 TRIAP1, MDM35 TRIAP1/MDM35 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K17968 O43715 224 2.6e-17 TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens GN=TRIAP1 PE=1 SV=1 PF05051//PF11093//PF06305 Cytochrome C oxidase copper chaperone (COX17)//Mitochondrial export protein Som1//Protein of unknown function (DUF1049) GO:0006825 copper ion transport GO:0016531//GO:0005507 copper chaperone activity//copper ion binding GO:0042720//GO:0005887//GO:0005758 mitochondrial inner membrane peptidase complex//integral component of plasma membrane//mitochondrial intermembrane space KOG3481 Uncharacterized conserved protein Cluster-8309.26920 BF_2 256.73 2.60 4417 642921248 XP_969543.2 924 2.1e-96 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 Q7KQM6 245 4.6e-19 PERQ amino acid-rich with GYF domain-containing protein CG11148 OS=Drosophila melanogaster GN=CG11148 PE=1 SV=2 PF02213 GYF domain -- -- GO:0005515 protein binding -- -- KOG1862 GYF domain containing proteins Cluster-8309.26928 BF_2 31.00 1.65 1072 158301484 XP_321166.4 221 1.6e-15 AGAP001899-PA [Anopheles gambiae str. PEST]>gi|157012493|gb|EAA01044.4| AGAP001899-PA [Anopheles gambiae str. PEST] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 164 2.7e-10 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- GO:0003824 catalytic activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.26931 BF_2 2.00 0.57 433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26933 BF_2 40.30 0.58 3191 546672885 ERL84608.1 1433 1.4e-155 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1101 1.8e-118 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0008152//GO:0006633//GO:0042967 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.26934 BF_2 303.31 5.90 2439 642928086 XP_008200150.1 3289 0.0e+00 PREDICTED: cleavage and polyadenylation specificity factor 73 [Tribolium castaneum] 642928085 XM_008201928.1 582 0 PREDICTED: Tribolium castaneum cleavage and polyadenylation specificity factor 73 (LOC103314846), mRNA K14403 CPSF3, YSH1 cleavage and polyadenylation specificity factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14403 Q9VE51 2622 6.0e-295 Cleavage and polyadenylation specificity factor 73 OS=Drosophila melanogaster GN=Cpsf73 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1137 mRNA cleavage and polyadenylation factor II complex, BRR5 (CPSF subunit) Cluster-8309.26937 BF_2 134.12 1.36 4399 642921365 XP_972788.2 3505 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 2.2931e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1306 4.3e-142 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF13639//PF12861//PF12678//PF00787//PF00097 Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//PX domain//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0035091//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//metal ion binding//phosphatidylinositol binding//protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.26938 BF_2 10.96 32.49 270 642923229 XP_008193666.1 440 1.7e-41 PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X2 [Tribolium castaneum] 642923230 XM_008195445.1 162 9.57036e-78 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X3, mRNA K14438 CHD9 chromodomain-helicase-DNA-binding protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14438 Q8BYH8 209 4.2e-16 Chromodomain-helicase-DNA-binding protein 9 OS=Mus musculus GN=Chd9 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26939 BF_2 8.00 0.54 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26940 BF_2 55.42 1.19 2235 749779658 XP_011144362.1 243 9.7e-18 PREDICTED: gamma-glutamyltranspeptidase 1-like isoform X2 [Harpegnathos saltator] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 205 1.0e-14 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019//PF13691 Gamma-glutamyltranspeptidase//tRNase Z endonuclease GO:0019530//GO:0008033//GO:0006691//GO:0006693//GO:0006749 taurine metabolic process//tRNA processing//leukotriene metabolic process//prostaglandin metabolic process//glutathione metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.26941 BF_2 64.00 1.44 2145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01194 RNA polymerases N / 8 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.26945 BF_2 34.69 1.01 1719 642912671 XP_969018.2 897 1.1e-93 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 O35298 829 3.4e-87 Acyloxyacyl hydrolase OS=Mus musculus GN=Aoah PE=2 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26946 BF_2 33.41 0.68 2351 642912671 XP_969018.2 1524 2.9e-166 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 P28039 932 5.3e-99 Acyloxyacyl hydrolase OS=Homo sapiens GN=AOAH PE=1 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.26948 BF_2 183.00 11.46 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26949 BF_2 1789.00 55.24 1642 91089913 XP_972686.1 1198 1.3e-128 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933954|ref|XP_008197580.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933957|ref|XP_008197581.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013662|gb|EFA10110.1| hypothetical protein TcasGA2_TC012289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 338 2.8e-30 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.26950 BF_2 278.16 5.53 2391 642916580 XP_008191778.1 2115 8.8e-235 PREDICTED: heterogeneous nuclear ribonucleoprotein L [Tribolium castaneum] 642916579 XM_008193556.1 484 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA K13159 HNRNPL heterogeneous nuclear ribonucleoprotein L http://www.genome.jp/dbget-bin/www_bget?ko:K13159 Q8R081 799 1.4e-83 Heterogeneous nuclear ribonucleoprotein L OS=Mus musculus GN=Hnrnpl PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1456 Heterogeneous nuclear ribonucleoprotein L (contains RRM repeats) Cluster-8309.26952 BF_2 27.00 0.92 1514 817190070 XP_012270387.1 169 2.5e-09 PREDICTED: longitudinals lacking protein, isoform G isoform X41 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q06730 134 1.2e-06 Zinc finger protein 33A OS=Homo sapiens GN=ZNF33A PE=1 SV=3 PF16622//PF01428//PF02892//PF00096//PF13465 zinc-finger C2H2-type//AN1-like Zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.26954 BF_2 565.88 11.29 2384 642930094 XP_008196249.1 3166 0.0e+00 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 179 1.1e-11 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00095//PF01424//PF02822//PF12740 WAP-type (Whey Acidic Protein) 'four-disulfide core'//R3H domain//Antistasin family//Chlorophyllase enzyme GO:0015994//GO:0015996 chlorophyll metabolic process//chlorophyll catabolic process GO:0030414//GO:0004867//GO:0047746//GO:0003676 peptidase inhibitor activity//serine-type endopeptidase inhibitor activity//chlorophyllase activity//nucleic acid binding GO:0005576 extracellular region KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.26955 BF_2 566.58 13.00 2110 642930094 XP_008196249.1 2451 8.4e-274 PREDICTED: uncharacterized protein LOC655867 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03610 212 1.5e-15 Uncharacterized protein ZC84.1 OS=Caenorhabditis elegans GN=ZC84.1 PE=3 SV=6 PF00014//PF02822 Kunitz/Bovine pancreatic trypsin inhibitor domain//Antistasin family -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.26958 BF_2 337.00 7.22 2240 642929069 XP_974078.2 1137 2.1e-121 PREDICTED: RING finger and CHY zinc finger domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K10144 RCHY1, PIRH2 RING finger and CHY zinc finger domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10144 Q9CR50 729 1.8e-75 RING finger and CHY zinc finger domain-containing protein 1 OS=Mus musculus GN=Rchy1 PE=1 SV=1 PF14634//PF13639//PF05495 zinc-RING finger domain//Ring finger domain//CHY zinc finger -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1940 Zn-finger protein Cluster-8309.26959 BF_2 5.00 4.20 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2696 BF_2 18.00 1.52 781 91090688 XP_974634.1 437 1.1e-40 PREDICTED: ribonuclease P/MRP protein subunit POP5 [Tribolium castaneum]>gi|270013940|gb|EFA10388.1| hypothetical protein TcasGA2_TC012619 [Tribolium castaneum] -- -- -- -- -- K03537 POP5 ribonuclease P/MRP protein subunit POP5 http://www.genome.jp/dbget-bin/www_bget?ko:K03537 Q5BJI6 191 1.5e-13 Ribonuclease P/MRP protein subunit POP5 OS=Danio rerio GN=pop5 PE=2 SV=1 PF01900 Rpp14/Pop5 family GO:0016070//GO:0051252//GO:0008033 RNA metabolic process//regulation of RNA metabolic process//tRNA processing GO:0004540 ribonuclease activity -- -- -- -- Cluster-8309.26964 BF_2 116.80 6.75 1011 332373824 AEE62053.1 803 5.1e-83 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q08623 577 3.3e-58 Pseudouridine-5'-phosphatase OS=Homo sapiens GN=HDHD1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.26966 BF_2 268.00 19.44 864 91078414 XP_974638.1 508 7.0e-49 PREDICTED: huntingtin-interacting protein K [Tribolium castaneum]>gi|270004001|gb|EFA00449.1| hypothetical protein TcasGA2_TC003305 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2PFU1 328 2.1e-29 Huntingtin-interacting protein K OS=Macaca fascicularis GN=HYPK PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3450 Huntingtin interacting protein HYPK Cluster-8309.26969 BF_2 286.28 3.08 4178 642913613 XP_008201088.1 4144 0.0e+00 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X3 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 2368 2.9e-265 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0941 E3 ubiquitin protein ligase Cluster-8309.26971 BF_2 91.40 1.03 3991 642939478 XP_008197026.1 2215 3.7e-246 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 830 6.1e-87 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF04923//PF07690 Ninjurin//Major Facilitator Superfamily GO:0042246//GO:0007155//GO:0055085 tissue regeneration//cell adhesion//transmembrane transport -- -- GO:0016021 integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.26972 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26975 BF_2 437.96 3.52 5494 91075990 XP_970704.1 2621 4.3e-293 PREDICTED: synaptojanin-1 isoform X1 [Tribolium castaneum]>gi|270014666|gb|EFA11114.1| hypothetical protein TcasGA2_TC004712 [Tribolium castaneum] 642910454 XM_008192523.1 588 0 PREDICTED: Tribolium castaneum synaptojanin-1 (LOC659292), transcript variant X2, mRNA K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 O43426 1661 3.7e-183 Synaptojanin-1 OS=Homo sapiens GN=SYNJ1 PE=1 SV=2 PF02383 SacI homology domain GO:0046854 phosphatidylinositol phosphorylation GO:0042578//GO:0000166 phosphoric ester hydrolase activity//nucleotide binding -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.26976 BF_2 5.00 0.55 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26979 BF_2 201.02 19.21 725 270007276 EFA03724.1 319 4.8e-27 hypothetical protein TcasGA2_TC013829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22978 229 5.4e-18 Heat shock protein 67B2 OS=Drosophila melanogaster GN=Hsp67Bb PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1530 Rhodanese-related sulfurtransferase Cluster-8309.26980 BF_2 25.02 1.89 841 270007276 EFA03724.1 142 1.9e-06 hypothetical protein TcasGA2_TC013829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26981 BF_2 235.00 13.22 1031 478261905 ENN80963.1 428 1.6e-39 hypothetical protein YQE_02626, partial [Dendroctonus ponderosae]>gi|546681991|gb|ERL91987.1| hypothetical protein D910_09310 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BRJ6 148 1.9e-08 Uncharacterized protein C7orf50 OS=Homo sapiens GN=C7orf50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.26983 BF_2 267.16 2.17 5430 642939323 XP_969087.2 928 8.7e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.68035e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01588//PF03876 Putative tRNA binding domain//SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0000049 DNA-directed RNA polymerase activity//tRNA binding GO:0005730 nucleolus KOG2241 tRNA-binding protein Cluster-8309.26986 BF_2 2020.59 23.99 3810 478255919 ENN76121.1 2740 4.7e-307 hypothetical protein YQE_07341, partial [Dendroctonus ponderosae]>gi|546676534|gb|ERL87528.1| hypothetical protein D910_04919 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26988 BF_2 1054.38 6.19 7408 478253975 ENN74267.1 3685 0.0e+00 hypothetical protein YQE_09239, partial [Dendroctonus ponderosae] 642910904 XM_008195237.1 248 4.63473e-124 PREDICTED: Tribolium castaneum trithorax group protein osa (LOC100141527), mRNA K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 1475 1.8e-161 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 PF01388//PF00375//PF12031//PF15750 ARID/BRIGHT DNA binding domain//Sodium:dicarboxylate symporter family//Domain of unknown function (DUF3518)//Ubiquitin-binding zinc-finger GO:0006812//GO:0006835//GO:0006820//GO:0006338 cation transport//dicarboxylic acid transport//anion transport//chromatin remodeling GO:0017153//GO:0003677//GO:0043130 sodium:dicarboxylate symporter activity//DNA binding//ubiquitin binding GO:0090544//GO:0016020 BAF-type complex//membrane KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-8309.26992 BF_2 215.11 1.90 5011 91085785 XP_974463.1 2481 6.7e-277 PREDICTED: glutamate decarboxylase [Tribolium castaneum]>gi|270009994|gb|EFA06442.1| hypothetical protein TcasGA2_TC009324 [Tribolium castaneum] 801384371 XM_012200006.1 259 2.40193e-130 PREDICTED: Atta cephalotes glutamate decarboxylase (LOC105618472), mRNA K01580 E4.1.1.15, gadB, gadA, GAD glutamate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01580 P20228 2105 1.1e-234 Glutamate decarboxylase OS=Drosophila melanogaster GN=Gad1 PE=2 SV=2 PF01276//PF00155//PF00282//PF01212//PF05889 Orn/Lys/Arg decarboxylase, major domain//Aminotransferase class I and II//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GO:0019752//GO:0006520//GO:0009058 carboxylic acid metabolic process//cellular amino acid metabolic process//biosynthetic process GO:0016831//GO:0016740//GO:0003824//GO:0030170//GO:0016829 carboxy-lyase activity//transferase activity//catalytic activity//pyridoxal phosphate binding//lyase activity -- -- KOG0629 Glutamate decarboxylase and related proteins Cluster-8309.26994 BF_2 110.49 4.35 1349 478256925 ENN77094.1 666 5.2e-67 hypothetical protein YQE_06429, partial [Dendroctonus ponderosae]>gi|546683033|gb|ERL92899.1| hypothetical protein D910_10204 [Dendroctonus ponderosae] -- -- -- -- -- K06963 TAN1, THUMPD1 tRNA acetyltransferase TAN1 http://www.genome.jp/dbget-bin/www_bget?ko:K06963 Q9VZD8 442 2.0e-42 THUMP domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG15014 PE=1 SV=2 PF02926//PF03526 THUMP domain//Colicin E1 (microcin) immunity protein GO:0030153//GO:0006955 bacteriocin immunity//immune response GO:0003723//GO:0015643 RNA binding//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.26995 BF_2 2.00 0.52 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.26997 BF_2 57.19 0.83 3153 642939454 XP_008200409.1 1501 1.8e-163 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|270016515|gb|EFA12961.1| hypothetical protein TcasGA2_TC001412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 689 1.1e-70 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.26999 BF_2 12.00 0.32 1836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2700 BF_2 15.00 3.25 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09496 Cenp-O kinetochore centromere component GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-8309.27000 BF_2 220.51 4.13 2519 642918373 XP_008200053.1 3550 0.0e+00 PREDICTED: ankyrin-3-like isoform X4 [Tribolium castaneum] 462367530 APGK01026876.1 85 6.38444e-34 Dendroctonus ponderosae Seq01026886, whole genome shotgun sequence K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q01484 2610 1.5e-293 Ankyrin-2 OS=Homo sapiens GN=ANK2 PE=1 SV=4 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27008 BF_2 6.75 0.45 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27010 BF_2 47.00 2.95 954 -- -- -- -- -- 642924012 XM_970745.2 91 1.09273e-37 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27015 BF_2 484.81 7.90 2853 91087855 XP_968688.1 2489 4.5e-278 PREDICTED: vacuolar protein sorting-associated protein 33A [Tribolium castaneum]>gi|270012007|gb|EFA08455.1| hypothetical protein TcasGA2_TC006102 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63615 1434 4.0e-157 Vacuolar protein sorting-associated protein 33A OS=Rattus norvegicus GN=Vps33a PE=1 SV=1 PF00995 Sec1 family GO:0006904//GO:0016192 vesicle docking involved in exocytosis//vesicle-mediated transport -- -- -- -- KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.27017 BF_2 2052.00 74.59 1438 646714197 KDR18262.1 1480 2.3e-161 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Zootermopsis nevadensis] 768953916 XM_011617434.1 209 4.22483e-103 PREDICTED: Takifugu rubripes STT3A, subunit of the oligosaccharyltransferase complex (catalytic) (stt3a), transcript variant X2, mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 P46977 1382 2.1e-151 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Homo sapiens GN=STT3A PE=1 SV=2 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016020 oligosaccharyltransferase complex//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.27018 BF_2 14.18 0.65 1198 642922873 XP_008200433.1 1207 8.5e-130 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Tribolium castaneum]>gi|270006562|gb|EFA03010.1| hypothetical protein TcasGA2_TC010433 [Tribolium castaneum] 195346084 XM_002039563.1 222 2.07812e-110 Drosophila sechellia GM22642 (Dsec\GM22642), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q5RCE2 1030 1.2e-110 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Pongo abelii GN=STT3A PE=2 SV=1 PF02516//PF10034 Oligosaccharyl transferase STT3 subunit//Q-cell neuroblast polarisation GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016021//GO:0016020 oligosaccharyltransferase complex//integral component of membrane//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.27020 BF_2 35.00 6.81 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27021 BF_2 193.39 2.84 3140 270004099 EFA00547.1 894 4.4e-93 hypothetical protein TcasGA2_TC003413 [Tribolium castaneum] 442633737 NM_176374.2 163 3.48173e-77 Drosophila melanogaster knirps-like (knrl), mRNA K08706 NR0AN, kni nuclear receptor subfamily 0 group A http://www.genome.jp/dbget-bin/www_bget?ko:K08706 P13054 507 1.4e-49 Knirps-related protein OS=Drosophila melanogaster GN=knrl PE=2 SV=1 PF00105//PF00645 Zinc finger, C4 type (two domains)//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0008270//GO:0003700 DNA binding//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.27022 BF_2 19.00 0.74 1355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.27028 BF_2 33.37 0.58 2714 -- -- -- -- -- 642914349 XM_008203421.1 47 9.15649e-13 PREDICTED: Tribolium castaneum inhibitor of apoptosis 1 (LOC663941), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27029 BF_2 7.19 0.32 1232 264681482 NP_001161130.1 576 1.3e-56 uncharacterized protein LOC660544 precursor [Tribolium castaneum]>gi|262316919|emb|CBC01171.1| chymotrypsin-like proteinase 6A precursor [Tribolium castaneum]>gi|270009251|gb|EFA05699.1| serine protease P155 [Tribolium castaneum] -- -- -- -- -- K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 Q2KJ63 354 2.9e-32 Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 PF00089//PF01418 Trypsin//Helix-turn-helix domain, rpiR family GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0004252//GO:0003700//GO:0016787 serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding//hydrolase activity GO:0005667 transcription factor complex -- -- Cluster-8309.2703 BF_2 1.00 0.72 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27030 BF_2 16.72 0.33 2404 642938298 XP_008192776.1 1719 7.3e-189 PREDICTED: late secretory pathway protein AVL9 homolog [Tribolium castaneum] 820839237 XM_012495150.1 168 4.41663e-80 PREDICTED: Apis florea late secretory pathway protein AVL9 homolog (LOC100871294), mRNA -- -- -- -- Q8NBF6 938 1.1e-99 Late secretory pathway protein AVL9 homolog OS=Homo sapiens GN=AVL9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3823 Uncharacterized conserved protein Cluster-8309.27032 BF_2 153.83 3.55 2101 91092806 XP_967025.1 2066 3.7e-229 PREDICTED: protein henna [Tribolium castaneum]>gi|270003060|gb|EEZ99507.1| hypothetical protein TcasGA2_TC000087 [Tribolium castaneum] -- -- -- -- -- K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1713 1.3e-189 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF01842//PF00351 ACT domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0008152//GO:0006559//GO:0009094//GO:0055114//GO:0006571//GO:0000162 metabolic process//L-phenylalanine catabolic process//L-phenylalanine biosynthetic process//oxidation-reduction process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0016714//GO:0016597//GO:0005506//GO:0004505 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//amino acid binding//iron ion binding//phenylalanine 4-monooxygenase activity -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.27035 BF_2 33.00 2.50 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27036 BF_2 70.24 2.55 1441 642928783 XP_966475.2 657 6.1e-66 PREDICTED: uncharacterized protein LOC654941 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27037 BF_2 14.69 0.40 1824 270008771 EFA05219.1 1061 1.1e-112 hypothetical protein TcasGA2_TC015360 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51814 395 7.7e-37 Zinc finger protein 41 OS=Homo sapiens GN=ZNF41 PE=1 SV=2 PF13912//PF02892//PF16622//PF07776//PF13465//PF00096//PF05443 C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//ROS/MUCR transcriptional regulator protein GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.27038 BF_2 30.89 0.41 3454 805774445 XP_012137479.1 442 1.3e-40 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27039 BF_2 56.79 1.04 2576 642933271 XP_008197352.1 668 5.8e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933270 XM_008199130.1 229 5.83199e-114 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X1, mRNA -- -- -- -- Q65Z95 602 1.1e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.27043 BF_2 6.00 0.70 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27052 BF_2 33.80 2.90 774 189236834 XP_001812569.1 702 2.0e-71 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270005053|gb|EFA01501.1| hypothetical protein TcasGA2_TC007057 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0005488//GO:0008270//GO:0046872 binding//zinc ion binding//metal ion binding GO:0005634//GO:0005622 nucleus//intracellular -- -- Cluster-8309.27053 BF_2 679.01 4.59 6479 642918446 XP_008191478.1 2992 0.0e+00 PREDICTED: protein zer-1 homolog [Tribolium castaneum]>gi|270003243|gb|EEZ99690.1| hypothetical protein TcasGA2_TC002447 [Tribolium castaneum] 769838188 XM_011631947.1 151 3.38471e-70 PREDICTED: Pogonomyrmex barbatus probable deoxyhypusine synthase (LOC105422536), transcript variant X6, mRNA K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q9W0E8 1706 2.6e-188 Protein zer-1 homolog OS=Drosophila melanogaster GN=CG12084 PE=2 SV=2 PF01916//PF13855//PF00514//PF03792//PF00560 Deoxyhypusine synthase//Leucine rich repeat//Armadillo/beta-catenin-like repeat//PBC domain//Leucine Rich Repeat GO:0008612 peptidyl-lysine modification to peptidyl-hypusine GO:0003700//GO:0005515 transcription factor activity, sequence-specific DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2924 Deoxyhypusine synthase Cluster-8309.27054 BF_2 24.89 1.36 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27057 BF_2 19.53 0.53 1840 546679701 ERL90124.1 140 7.0e-06 hypothetical protein D910_07478 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27058 BF_2 491.24 7.47 3037 642910587 XP_008200015.1 1547 8.1e-169 PREDICTED: cap-n-collar isoform X6 [Tribolium castaneum] -- -- -- -- -- K09040 NFE2L1_3 nuclear factor erythroid 2-related factor 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09040 P20482 736 3.7e-76 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF03126//PF03131//PF07716//PF00170 Plus-3 domain//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3863 bZIP transcription factor NRF1 Cluster-8309.27059 BF_2 22.93 0.46 2381 642910579 XP_008200011.1 220 4.8e-15 PREDICTED: cap-n-collar isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27060 BF_2 6.94 9.33 303 546676979 ERL87903.1 240 2.9e-18 hypothetical protein D910_05291 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 160 2.3e-10 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27062 BF_2 365.46 2.84 5679 642933274 XP_008197353.1 3621 0.0e+00 PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 [Tribolium castaneum] 850480667 CP011888.1 37 6.98873e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 1848 7.8e-205 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF00443//PF09061//PF01612//PF03798//PF05868 Ubiquitin carboxyl-terminal hydrolase//Stirrup//3'-5' exonuclease//TLC domain//Rotavirus major outer capsid protein VP7 GO:0016579//GO:0006139 protein deubiquitination//nucleobase-containing compound metabolic process GO:0008408//GO:0003676//GO:0036459//GO:0016788 3'-5' exonuclease activity//nucleic acid binding//ubiquitinyl hydrolase activity//hydrolase activity, acting on ester bonds GO:0019012//GO:0016021 virion//integral component of membrane KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.27063 BF_2 710.54 13.63 2468 189233973 XP_975713.2 2235 1.1e-248 PREDICTED: serine/threonine-protein kinase 3 [Tribolium castaneum]>gi|270014571|gb|EFA11019.1| hypothetical protein TcasGA2_TC004606 [Tribolium castaneum] 156389256 XM_001634858.1 179 3.48178e-86 Nematostella vectensis predicted protein (NEMVEDRAFT_v1g241948) partial mRNA K04412 STK3, MST2 serine/threonine kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04412 Q6IP06 1497 1.7e-164 Serine/threonine-protein kinase 3 OS=Xenopus laevis GN=stk3 PE=2 SV=1 PF00069//PF07714//PF11629//PF16517 Protein kinase domain//Protein tyrosine kinase//C terminal SARAH domain of Mst1//Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain GO:0007165//GO:0006468//GO:0009069//GO:0016310 signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0574 STE20-like serine/threonine kinase MST Cluster-8309.27064 BF_2 1.00 3.32 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27065 BF_2 24.67 0.35 3200 270012872 EFA09320.1 264 5.1e-20 hypothetical protein TcasGA2_TC001646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10394 Histone acetyl transferase HAT1 N-terminus GO:0042967//GO:0016568 acyl-carrier-protein biosynthetic process//chromatin modification GO:0004402 histone acetyltransferase activity GO:0000123 histone acetyltransferase complex -- -- Cluster-8309.27066 BF_2 3148.70 52.33 2804 642930412 XP_008196389.1 2518 1.9e-281 PREDICTED: beta-mannosidase-like [Tribolium castaneum] 537740069 HG315671.1 48 2.63141e-13 Formosa agariphila KMM 3901, complete genome K01192 E3.2.1.25, MANBA, manB beta-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01192 Q95327 1676 3.4e-185 Beta-mannosidase OS=Capra hircus GN=MANBA PE=2 SV=1 PF02837//PF00703//PF07527//PF02836 Glycosyl hydrolases family 2, sugar binding domain//Glycosyl hydrolases family 2//Hairy Orange//Glycosyl hydrolases family 2, TIM barrel domain GO:0006355//GO:0005975 regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0003677//GO:0004553 DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2230 Predicted beta-mannosidase Cluster-8309.27068 BF_2 174.05 2.93 2768 478256149 ENN76347.1 3557 0.0e+00 hypothetical protein YQE_07124, partial [Dendroctonus ponderosae] 817202050 XM_012421374.1 256 6.13677e-129 PREDICTED: Orussus abietinus DNA replication licensing factor Mcm2 (LOC105697752), mRNA K02540 MCM2 DNA replication licensing factor MCM2 http://www.genome.jp/dbget-bin/www_bget?ko:K02540 P49735 3053 0.0e+00 DNA replication licensing factor Mcm2 OS=Drosophila melanogaster GN=Mcm2 PE=1 SV=1 PF00493//PF00004//PF12619//PF07728//PF07726//PF00158 MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//Mini-chromosome maintenance protein 2//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain GO:0006270//GO:0006355//GO:0006260 DNA replication initiation//regulation of transcription, DNA-templated//DNA replication GO:0003678//GO:0005524//GO:0003677//GO:0008134//GO:0016887 DNA helicase activity//ATP binding//DNA binding//transcription factor binding//ATPase activity GO:0005634//GO:0005657//GO:0005667//GO:0042555 nucleus//replication fork//transcription factor complex//MCM complex KOG0477 DNA replication licensing factor, MCM2 component Cluster-8309.27070 BF_2 37.09 0.38 4374 642933797 XP_008197328.1 2022 9.8e-224 PREDICTED: multidrug resistance-associated protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q8HXQ5 1232 1.6e-133 Multidrug resistance-associated protein 1 OS=Bos taurus GN=ABCC1 PE=2 SV=1 PF13304//PF01926//PF00664//PF03193//PF00005//PF17001//PF06414//PF09547//PF01637//PF08603 AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Zeta toxin//Stage IV sporulation protein A (spore_IV_A)//Archaeal ATPase//Adenylate cyclase associated (CAP) C terminal GO:0009306//GO:0007010//GO:0006810//GO:0055085//GO:0043934 protein secretion//cytoskeleton organization//transport//transmembrane transport//sporulation GO:0003924//GO:0003779//GO:0005524//GO:0042626//GO:0005525//GO:0016887//GO:0016301 GTPase activity//actin binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.27073 BF_2 124.77 1.04 5318 91076774 XP_973840.1 1189 4.6e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.78062e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 6.0e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF07728//PF04106//PF16094//PF06309//PF03135 AAA domain (dynein-related subfamily)//Autophagy protein Apg5//Proteasome assembly chaperone 4//Torsin//CagE, TrbE, VirB family, component of type IV transporter system GO:0043248//GO:0006914 proteasome assembly//autophagy GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0005737//GO:0005783 cytoplasm//endoplasmic reticulum KOG2170 ATPase of the AAA+ superfamily Cluster-8309.27075 BF_2 274.88 3.87 3257 91085763 XP_974155.1 2794 0.0e+00 PREDICTED: polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270009999|gb|EFA06447.1| hypothetical protein TcasGA2_TC009329 [Tribolium castaneum] -- -- -- -- -- K00962 pnp, PNPT1 polyribonucleotide nucleotidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00962 Q8TCS8 2002 6.2e-223 Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Homo sapiens GN=PNPT1 PE=1 SV=2 PF03726//PF00013//PF00575 Polyribonucleotide nucleotidyltransferase, RNA binding domain//KH domain//S1 RNA binding domain GO:0006206//GO:0006396//GO:0051252//GO:0006402//GO:0006144 pyrimidine nucleobase metabolic process//RNA processing//regulation of RNA metabolic process//mRNA catabolic process//purine nucleobase metabolic process GO:0003676//GO:0003723//GO:0004654//GO:0000175 nucleic acid binding//RNA binding//polyribonucleotide nucleotidyltransferase activity//3'-5'-exoribonuclease activity -- -- KOG1067 Predicted RNA-binding polyribonucleotide nucleotidyltransferase Cluster-8309.27076 BF_2 1.70 0.31 513 478256535 ENN76719.1 418 1.1e-38 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8NB50 265 2.5e-22 Zinc finger protein 62 homolog OS=Homo sapiens GN=ZFP62 PE=2 SV=3 PF13465//PF00096//PF13912//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.27077 BF_2 114.32 2.93 1918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27078 BF_2 60.00 3.23 1065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27080 BF_2 777.90 11.19 3196 642918916 XP_008191654.1 4256 0.0e+00 PREDICTED: apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1 [Tribolium castaneum] 194759777 XM_001962088.1 63 1.37802e-21 Drosophila ananassae GF14596 (Dana\GF14596), mRNA -- -- -- -- O15033 1602 1.5e-176 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Homo sapiens GN=AREL1 PE=1 SV=3 PF00632//PF00536//PF07647 HECT-domain (ubiquitin-transferase)//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.27081 BF_2 29.29 0.60 2342 642918918 XP_008191656.1 1771 6.7e-195 PREDICTED: apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X2 [Tribolium castaneum] 194759777 XM_001962088.1 63 1.00636e-21 Drosophila ananassae GF14596 (Dana\GF14596), mRNA -- -- -- -- Q8CHG5 397 5.8e-37 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Mus musculus GN=Arel1 PE=2 SV=2 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27082 BF_2 15.00 0.41 1815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27084 BF_2 61.73 0.57 4816 642931607 XP_008196654.1 2938 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 639 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 2276 1.6e-254 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF02170//PF02171//PF04810 PAZ domain//Piwi domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0005515 nucleic acid binding//zinc ion binding//protein binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.27085 BF_2 21.19 0.66 1640 642930414 XP_008196390.1 488 2.8e-46 PREDICTED: BAG family molecular chaperone regulator 2 [Tribolium castaneum]>gi|270009406|gb|EFA05854.1| hypothetical protein TcasGA2_TC008649 [Tribolium castaneum] -- -- -- -- -- K09556 BAG2 BCL2-associated athanogene 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09556 Q91YN9 217 3.0e-16 BAG family molecular chaperone regulator 2 OS=Mus musculus GN=Bag2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3633 BAG family molecular chaperone regulator 2 Cluster-8309.27086 BF_2 835.70 17.77 2255 478255733 ENN75942.1 1756 3.5e-193 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 789 2.0e-82 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF08119//PF00097 Scorpion acidic alpha-KTx toxin family//Zinc finger, C3HC4 type (RING finger) GO:0009405//GO:0006810 pathogenesis//transport GO:0046872//GO:0019870 metal ion binding//potassium channel inhibitor activity GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.27087 BF_2 7.05 0.51 865 190702371 ACE75264.1 758 7.2e-78 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27089 BF_2 155.01 2.29 3121 642935794 XP_008198177.1 372 1.5e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03823//PF00335//PF01694 Neurokinin B//Tetraspanin family//Rhomboid family GO:0007217 tachykinin receptor signaling pathway GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.27090 BF_2 33.00 1.00 1661 642937618 XP_008199124.1 681 1.2e-68 PREDICTED: barH-like 1 homeobox protein [Tribolium castaneum] 345483554 XM_003424793.1 113 1.13757e-49 PREDICTED: Nasonia vitripennis homeobox protein B-H2-like (LOC100679231), mRNA K09360 BARHL BarH-like http://www.genome.jp/dbget-bin/www_bget?ko:K09360 Q24255 513 1.4e-50 Homeobox protein B-H1 OS=Drosophila melanogaster GN=B-H1 PE=2 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0488 Transcription factor BarH and related HOX domain proteins Cluster-8309.27091 BF_2 4.02 3.79 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27092 BF_2 244.04 29.26 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27093 BF_2 20.96 1.74 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27094 BF_2 151.14 2.33 3001 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27095 BF_2 64.61 0.38 7372 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 8.7e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF08477//PF03810//PF01926//PF07817//PF02421//PF03193//PF00071//PF04548 Ras of Complex, Roc, domain of DAPkinase//Importin-beta N-terminal domain//50S ribosome-binding GTPase//GLE1-like protein//Ferrous iron transport protein B//Protein of unknown function, DUF258//Ras family//AIG1 family GO:0016973//GO:0006886//GO:0015031//GO:0015684//GO:0007264 poly(A)+ mRNA export from nucleus//intracellular protein transport//protein transport//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0008536//GO:0015093//GO:0008565//GO:0005525 GTPase activity//Ran GTPase binding//ferrous iron transmembrane transporter activity//protein transporter activity//GTP binding GO:0016021//GO:0005643 integral component of membrane//nuclear pore KOG3068 mRNA splicing factor Cluster-8309.27096 BF_2 56.10 0.31 7743 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.2e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF00071//PF02421//PF08477//PF03810//PF03193//PF01926//PF07817 Ras family//Ferrous iron transport protein B//Ras of Complex, Roc, domain of DAPkinase//Importin-beta N-terminal domain//Protein of unknown function, DUF258//50S ribosome-binding GTPase//GLE1-like protein GO:0007264//GO:0015031//GO:0015684//GO:0006886//GO:0016973 small GTPase mediated signal transduction//protein transport//ferrous iron transport//intracellular protein transport//poly(A)+ mRNA export from nucleus GO:0005525//GO:0008565//GO:0008536//GO:0003924//GO:0015093 GTP binding//protein transporter activity//Ran GTPase binding//GTPase activity//ferrous iron transmembrane transporter activity GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.27097 BF_2 6.00 2.47 387 123423385 XP_001306365.1 235 1.4e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121887935|gb|EAX93435.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 230 2.2e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27098 BF_2 2.00 0.51 452 780175874 XP_011661330.1 234 2.1e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q8ZWC4 220 3.7e-17 Putative ankyrin repeat protein PAE1861 OS=Pyrobaculum aerophilum (strain ATCC 51768 / IM2 / DSM 7523 / JCM 9630 / NBRC 100827) GN=PAE1861 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27099 BF_2 1.00 0.84 329 642934266 XP_008200866.1 158 1.0e-08 PREDICTED: uncharacterized protein LOC103314998 isoform X26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2RXR6 147 7.9e-09 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Mus musculus GN=Ankrd44 PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27102 BF_2 4.00 0.45 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27103 BF_2 22.26 1.34 982 270004583 EFA01031.1 541 1.2e-52 hypothetical protein TcasGA2_TC003947 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P35789 481 4.4e-47 Zinc finger protein 93 OS=Homo sapiens GN=ZNF93 PE=2 SV=4 PF00096//PF13465//PF13912//PF01258 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.27104 BF_2 18.19 2.40 604 642920011 XP_008192166.1 546 1.9e-53 PREDICTED: stromal interaction molecule homolog isoform X4 [Tribolium castaneum] -- -- -- -- -- K18196 STIM2 stromal interaction molecule 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18196 P83094 503 7.6e-50 Stromal interaction molecule homolog OS=Drosophila melanogaster GN=Stim PE=1 SV=1 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- KOG4403 Cell surface glycoprotein STIM, contains SAM domain Cluster-8309.27105 BF_2 459.00 20.11 1242 91084417 XP_967827.1 582 2.6e-57 PREDICTED: chromobox protein homolog 3 [Tribolium castaneum]>gi|270008703|gb|EFA05151.1| hypothetical protein TcasGA2_TC015268 [Tribolium castaneum] -- -- -- -- -- K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 P83917 433 2.1e-41 Chromobox protein homolog 1 OS=Mus musculus GN=Cbx1 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.27107 BF_2 103.01 0.95 4838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27110 BF_2 7.00 0.84 635 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27116 BF_2 492.36 7.65 2979 91086463 XP_969857.1 1953 6.7e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 3.8e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.27118 BF_2 169.85 2.27 3417 546685535 ERL95022.1 492 2.0e-46 hypothetical protein D910_12292 [Dendroctonus ponderosae] 449102215 JX081307.1 150 6.39115e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 1.1e-44 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.27121 BF_2 2.27 0.34 565 642932174 XP_008196886.1 179 6.4e-11 PREDICTED: RE1-silencing transcription factor B-like [Tribolium castaneum]>gi|270011690|gb|EFA08138.1| hypothetical protein TcasGA2_TC005755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54963 160 4.2e-10 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.27123 BF_2 460.38 4.37 4690 546678980 ERL89513.1 1263 1.1e-135 hypothetical protein D910_06879 [Dendroctonus ponderosae] 850318596 XM_013007893.1 39 4.45575e-08 PREDICTED: Echinops telfairi L-lactate dehydrogenase A chain-like (LOC101645051), mRNA K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1195 3.4e-129 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF00056//PF03721//PF02427//PF02737//PF02866 lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Photosystem I reaction centre subunit IV / PsaE//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0006552//GO:0006631//GO:0015979//GO:0018874//GO:0006633//GO:0006554//GO:0055114//GO:0006568//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//photosynthesis//benzoate metabolic process//fatty acid biosynthetic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//valine catabolic process//isoleucine catabolic process GO:0016491//GO:0051287//GO:0003857//GO:0016616 oxidoreductase activity//NAD binding//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0009538//GO:0009522 photosystem I reaction center//photosystem I KOG1495 Lactate dehydrogenase Cluster-8309.27124 BF_2 95.62 0.63 6607 642921412 XP_008192854.1 1035 4.1e-109 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.59356e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 747 4.2e-77 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.27125 BF_2 163.00 6.31 1368 642931070 XP_008196199.1 579 6.4e-57 PREDICTED: uncharacterized protein LOC103313796 [Tribolium castaneum]>gi|270012066|gb|EFA08514.1| hypothetical protein TcasGA2_TC006167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27126 BF_2 76.66 3.90 1110 817079505 XP_012262173.1 280 2.5e-22 PREDICTED: zinc finger protein 706-like [Athalia rosae]>gi|817079507|ref|XP_012262174.1| PREDICTED: zinc finger protein 706-like [Athalia rosae] 389609616 AK401798.1 81 4.62922e-32 Papilio xuthus mRNA for similar to CG15715, complete cds, sequence id: Px-1382 -- -- -- -- Q5ZMM5 201 1.5e-14 Zinc finger protein 706 OS=Gallus gallus GN=ZNF706 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4118 Uncharacterized conserved protein Cluster-8309.27127 BF_2 183.97 6.14 1540 332372985 AEE61634.1 1497 2.6e-163 unknown [Dendroctonus ponderosae] 642937798 XM_008202083.1 221 9.67218e-110 PREDICTED: Tribolium castaneum cleavage stimulation factor subunit 2 tau variant (LOC659353), mRNA K14407 CSTF2, RNA15 cleavage stimulation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14407 Q8HXM1 717 3.0e-74 Cleavage stimulation factor subunit 2 OS=Bos taurus GN=CSTF2 PE=2 SV=1 PF00076//PF16367//PF14304 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Transcription termination and cleavage factor C-terminal GO:0031124 mRNA 3'-end processing GO:0003676 nucleic acid binding -- -- KOG0108 mRNA cleavage and polyadenylation factor I complex, subunit RNA15 Cluster-8309.27129 BF_2 735.21 13.35 2591 642922164 XP_008193042.1 3107 0.0e+00 PREDICTED: glycine--tRNA ligase [Tribolium castaneum] 170050074 XM_001859151.1 174 2.20143e-83 Culex quinquefasciatus glycyl-tRNA synthetase, mRNA K01880 GARS, glyS1 glycyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01880 Q04451 2649 4.7e-298 Glycine--tRNA ligase OS=Bombyx mori PE=1 SV=2 PF00458//PF00587 WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding -- -- KOG2298 Glycyl-tRNA synthetase and related class II tRNA synthetase Cluster-8309.27130 BF_2 702.64 5.34 5793 478255041 ENN75273.1 1173 3.6e-125 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 658861642 XM_008415365.1 133 3.06887e-60 PREDICTED: Poecilia reticulata phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 1058 3.2e-113 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF01409//PF00520//PF15461 tRNA synthetases class II core domain (F)//Ion transport protein//Beta-carotene 15,15'-dioxygenase GO:0055085//GO:0006811//GO:0055114//GO:0043039//GO:0006418 transmembrane transport//ion transport//oxidation-reduction process//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0016702//GO:0005524//GO:0004812//GO:0005216 tRNA binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//ATP binding//aminoacyl-tRNA ligase activity//ion channel activity GO:0005737//GO:0016020 cytoplasm//membrane KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.27134 BF_2 16.50 0.84 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.27139 BF_2 22.69 1.07 1172 332376146 AEE63213.1 517 8.5e-50 unknown [Dendroctonus ponderosae]>gi|478259623|gb|ENN79476.1| hypothetical protein YQE_04120, partial [Dendroctonus ponderosae]>gi|546679426|gb|ERL89890.1| hypothetical protein D910_07249 [Dendroctonus ponderosae] 815793034 XM_012361708.1 80 1.7588e-31 PREDICTED: Linepithema humile proteasome subunit alpha type-4 (LOC105668977), mRNA K02728 PSMA4 20S proteasome subunit alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02728 P21670 448 3.5e-43 Proteasome subunit alpha type-4 OS=Rattus norvegicus GN=Psma4 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0178 20S proteasome, regulatory subunit alpha type PSMA4/PRE9 Cluster-8309.27141 BF_2 70.99 0.98 3309 642920248 XP_008192267.1 972 4.2e-102 PREDICTED: probable cytochrome P450 6a14 [Tribolium castaneum]>gi|270006371|gb|EFA02819.1| cytochrome P450 6BQ5 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 744 4.7e-77 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067//PF00893//PF03776 Cytochrome P450//Small Multidrug Resistance protein//Septum formation topological specificity factor MinE GO:0032955//GO:0055114//GO:0051301 regulation of barrier septum assembly//oxidation-reduction process//cell division GO:0020037//GO:0005506//GO:0046872//GO:0016491//GO:0016705 heme binding//iron ion binding//metal ion binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016021 integral component of membrane -- -- Cluster-8309.27143 BF_2 119.00 6.63 1038 91079592 XP_967810.1 678 1.6e-68 PREDICTED: transmembrane protein 223 [Tribolium castaneum]>gi|270003397|gb|EEZ99844.1| hypothetical protein TcasGA2_TC002625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC58 304 1.6e-26 Transmembrane protein 223 OS=Danio rerio GN=tmem223 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27145 BF_2 808.00 8.11 4457 642920612 XP_008192488.1 986 1.3e-103 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08777//PF02214 RNA binding motif//BTB/POZ domain GO:0051260 protein homooligomerization GO:0003723 RNA binding -- -- -- -- Cluster-8309.27147 BF_2 62.99 0.58 4857 -- -- -- -- -- 642912444 XM_008202641.1 328 1.02333e-168 PREDICTED: Tribolium castaneum serum response factor (Srf), transcript variant X1, mRNA K04378 SRF serum response factor http://www.genome.jp/dbget-bin/www_bget?ko:K04378 Q3SXZ3 139 9.9e-07 Zinc finger protein 718 OS=Homo sapiens GN=ZNF718 PE=2 SV=1 PF13912//PF00319//PF00096//PF13465 C2H2-type zinc finger//SRF-type transcription factor (DNA-binding and dimerisation domain)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0046983//GO:0003677 metal ion binding//protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.27150 BF_2 232.00 6.07 1886 91080201 XP_971515.1 1535 1.2e-167 PREDICTED: serine/threonine-protein kinase RIO1 [Tribolium castaneum]>gi|270005675|gb|EFA02123.1| hypothetical protein TcasGA2_TC007772 [Tribolium castaneum] 765148024 XM_004078884.2 59 1.35113e-19 PREDICTED: Oryzias latipes RIO kinase 1 (riok1), mRNA K07178 RIOK1 RIO kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07178 Q9BRS2 1042 7.5e-112 Serine/threonine-protein kinase RIO1 OS=Homo sapiens GN=RIOK1 PE=1 SV=2 PF09266 Viral DNA topoisomerase I, N-terminal GO:0006265 DNA topological change GO:0016301//GO:0003677//GO:0000166//GO:0003916 kinase activity//DNA binding//nucleotide binding//DNA topoisomerase activity -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.27151 BF_2 58.60 1.88 1594 642929512 XP_975068.2 1055 4.8e-112 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Tribolium castaneum] 727003473 XM_010393578.1 39 1.49306e-08 PREDICTED: Corvus cornix cornix 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 O95861 725 3.6e-75 3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens GN=BPNT1 PE=1 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.27154 BF_2 2.00 0.45 472 642914485 XP_008201694.1 168 1.0e-09 PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|642914487|ref|XP_008201695.1| PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|270001489|gb|EEZ97936.1| hypothetical protein TcasGA2_TC000324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27155 BF_2 594.84 11.42 2466 642914485 XP_008201694.1 673 1.5e-67 PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|642914487|ref|XP_008201695.1| PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|270001489|gb|EEZ97936.1| hypothetical protein TcasGA2_TC000324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BL31 320 5.2e-28 Uncharacterized protein C6orf106 homolog OS=Danio rerio GN=zgc:101577 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27156 BF_2 85.10 28.76 410 642914485 XP_008201694.1 317 4.6e-27 PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|642914487|ref|XP_008201695.1| PREDICTED: uncharacterized protein C6orf106 homolog isoform X1 [Tribolium castaneum]>gi|270001489|gb|EEZ97936.1| hypothetical protein TcasGA2_TC000324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BL31 177 3.3e-12 Uncharacterized protein C6orf106 homolog OS=Danio rerio GN=zgc:101577 PE=2 SV=1 PF03943 TAP C-terminal domain GO:0051028 mRNA transport -- -- GO:0005634 nucleus -- -- Cluster-8309.27160 BF_2 118.00 2.49 2271 642920486 XP_008192371.1 1180 2.2e-126 PREDICTED: testis-specific serine/threonine-protein kinase 1-like [Tribolium castaneum]>gi|270005224|gb|EFA01672.1| hypothetical protein TcasGA2_TC007244 [Tribolium castaneum] -- -- -- -- -- K08811 TSSK, STK22 testis-specific serine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08811 Q3SZW1 562 4.1e-56 Testis-specific serine/threonine-protein kinase 1 OS=Bos taurus GN=TSSK1B PE=2 SV=1 PF01193//PF06293//PF00069//PF07714 RNA polymerase Rpb3/Rpb11 dimerisation domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0006351 protein phosphorylation//transcription, DNA-templated GO:0046983//GO:0004672//GO:0005524//GO:0016773 protein dimerization activity//protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0583 Serine/threonine protein kinase Cluster-8309.27163 BF_2 1097.24 14.13 3535 91090842 XP_972243.1 1069 2.5e-113 PREDICTED: large neutral amino acids transporter small subunit 1 [Tribolium castaneum]>gi|270013246|gb|EFA09694.1| hypothetical protein TcasGA2_TC011826 [Tribolium castaneum] 642935933 XM_967150.2 311 2.09446e-159 PREDICTED: Tribolium castaneum large neutral amino acids transporter small subunit 1 (LOC660956), mRNA K03450 SLC7A solute carrier family 7 (L-type amino acid transporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K03450 Q7YQK4 638 9.9e-65 Large neutral amino acids transporter small subunit 1 OS=Oryctolagus cuniculus GN=SLC7A5 PE=1 SV=1 PF00324//PF13520//PF04116//PF01384 Amino acid permease//Amino acid permease//Fatty acid hydroxylase superfamily//Phosphate transporter family GO:0006865//GO:0006633//GO:0055085//GO:0006817//GO:0006810//GO:0003333//GO:0055114 amino acid transport//fatty acid biosynthetic process//transmembrane transport//phosphate ion transport//transport//amino acid transmembrane transport//oxidation-reduction process GO:0015171//GO:0016491//GO:0005315//GO:0005506 amino acid transmembrane transporter activity//oxidoreductase activity//inorganic phosphate transmembrane transporter activity//iron ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1287 Amino acid transporters Cluster-8309.27170 BF_2 97.84 2.60 1862 642911933 XP_008199027.1 769 8.2e-79 PREDICTED: transmembrane protein 199 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N511 221 1.2e-16 Transmembrane protein 199 OS=Homo sapiens GN=TMEM199 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27171 BF_2 28.00 20.80 337 642911935 XP_008199028.1 315 6.5e-27 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 5-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZK77 131 5.8e-07 Biogenesis of lysosome-related organelles complex 1 subunit 5 OS=Gallus gallus GN=BLOC1S5 PE=2 SV=1 PF00558//PF14942 Vpu protein//Organelle biogenesis, Muted-like protein GO:0032801//GO:0019076//GO:0006812 receptor catabolic process//viral release from host cell//cation transport GO:0005261 cation channel activity GO:0031083//GO:0033644//GO:0030133 BLOC-1 complex//host cell membrane//transport vesicle -- -- Cluster-8309.27174 BF_2 55.26 1.89 1511 270009554 EFA06002.1 986 4.6e-104 hypothetical protein TcasGA2_TC008828 [Tribolium castaneum] -- -- -- -- -- K08742 SIAH2 E3 ubiquitin-protein ligase SIAH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08742 A8X679 278 2.3e-23 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF15965//PF00097//PF02891//PF03145 TRAF-like zinc-finger//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.27175 BF_2 72.38 1.23 2753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27176 BF_2 103.39 26.02 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27177 BF_2 237.00 6.25 1873 642912716 XP_008200973.1 517 1.4e-49 PREDICTED: uncharacterized protein LOC103315050 [Tribolium castaneum]>gi|270002368|gb|EEZ98815.1| hypothetical protein TcasGA2_TC004421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27179 BF_2 109.07 5.33 1143 642934633 XP_008197745.1 633 2.9e-63 PREDICTED: syntaxin-1A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24547 317 5.3e-28 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF05531//PF04111//PF00435//PF03811//PF07463//PF00804//PF00512//PF05008//PF05739 Nucleopolyhedrovirus P10 protein//Autophagy protein Apg6//Spectrin repeat//InsA N-terminal domain//NUMOD4 motif//Syntaxin//His Kinase A (phospho-acceptor) domain//Vesicle transport v-SNARE protein N-terminus//SNARE domain GO:0006914//GO:0006313//GO:0016310//GO:0006886//GO:0007165//GO:0000160 autophagy//transposition, DNA-mediated//phosphorylation//intracellular protein transport//signal transduction//phosphorelay signal transduction system GO:0005515//GO:0000155//GO:0016788 protein binding//phosphorelay sensor kinase activity//hydrolase activity, acting on ester bonds GO:0016020//GO:0009365//GO:0019028 membrane//protein histidine kinase complex//viral capsid KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.27181 BF_2 551.42 13.37 2012 478262704 ENN81251.1 2158 7.6e-240 hypothetical protein YQE_02345, partial [Dendroctonus ponderosae]>gi|546679053|gb|ERL89576.1| hypothetical protein D910_06941 [Dendroctonus ponderosae] 759080227 XM_011351649.1 232 9.75278e-116 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X5, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1209 3.5e-131 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.27185 BF_2 401.62 25.27 952 91078236 XP_966494.1 759 6.0e-78 PREDICTED: ras-related protein Rab-21 [Tribolium castaneum]>gi|270003941|gb|EFA00389.1| hypothetical protein TcasGA2_TC003235 [Tribolium castaneum] -- -- -- -- -- K07890 RAB21 Ras-related protein Rab-21 http://www.genome.jp/dbget-bin/www_bget?ko:K07890 P55745 689 3.2e-71 Ras-related protein Rab-21 OS=Canis familiaris GN=RAB21 PE=3 SV=3 PF03193//PF00107//PF04670//PF10662//PF00071//PF08477//PF01926//PF00025 Protein of unknown function, DUF258//Zinc-binding dehydrogenase//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family GO:0007264//GO:0055114//GO:0015031//GO:0006576 small GTPase mediated signal transduction//oxidation-reduction process//protein transport//cellular biogenic amine metabolic process GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.27188 BF_2 3.00 0.80 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27190 BF_2 3.00 0.54 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27192 BF_2 15.54 0.39 1935 -- -- -- -- -- 462313076 APGK01046348.1 42 3.91105e-10 Dendroctonus ponderosae Seq01046358, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27193 BF_2 20.13 0.59 1726 -- -- -- -- -- 462313076 APGK01046348.1 42 3.48083e-10 Dendroctonus ponderosae Seq01046358, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27196 BF_2 276.11 2.13 5708 642914968 XP_008190463.1 2570 3.6e-287 PREDICTED: kelch-like protein 5 [Tribolium castaneum] 701432439 XM_010006117.1 50 4.16835e-14 PREDICTED: Chaetura pelagica kelch-like family member 5 (KLHL5), transcript variant X3, mRNA K10442 KLHL1_4_5 kelch-like protein 1/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10442 Q96PQ7 1663 2.2e-183 Kelch-like protein 5 OS=Homo sapiens GN=KLHL5 PE=2 SV=3 PF03931//PF01344//PF10576//PF07646//PF00651 Skp1 family, tetramerisation domain//Kelch motif//Iron-sulfur binding domain of endonuclease III//Kelch motif//BTB/POZ domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515//GO:0051539 protein binding//4 iron, 4 sulfur cluster binding -- -- -- -- Cluster-8309.27197 BF_2 556.69 4.76 5177 478255922 ENN76124.1 725 2.9e-73 hypothetical protein YQE_07344, partial [Dendroctonus ponderosae]>gi|546676530|gb|ERL87524.1| hypothetical protein D910_04916 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46108 605 9.7e-61 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083//PF00837 Partial alpha/beta-hydrolase lipase region//Iodothyronine deiodinase GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process GO:0004800 thyroxine 5'-deiodinase activity -- -- -- -- Cluster-8309.27200 BF_2 143.14 1.24 5117 546676531 ERL87525.1 725 2.8e-73 hypothetical protein D910_04916 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46108 605 9.6e-61 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF00837//PF04083 Iodothyronine deiodinase//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process GO:0004800 thyroxine 5'-deiodinase activity -- -- -- -- Cluster-8309.27202 BF_2 294.00 3.30 4017 91079024 XP_974902.1 614 1.7e-60 PREDICTED: methyltransferase-like protein 10 [Tribolium castaneum]>gi|642916302|ref|XP_008190967.1| PREDICTED: methyltransferase-like protein 10 [Tribolium castaneum]>gi|642916304|ref|XP_008190968.1| PREDICTED: methyltransferase-like protein 10 [Tribolium castaneum]>gi|270004177|gb|EFA00625.1| hypothetical protein TcasGA2_TC003501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D853 438 1.7e-41 Protein-lysine N-methyltransferase Mettl10 OS=Mus musculus GN=Mettl10 PE=2 SV=1 PF05958//PF02005//PF01234//PF08241//PF02390//PF05724//PF01135//PF05175//PF05401//PF07757 tRNA (Uracil-5-)-methyltransferase//N2,N2-dimethylguanosine tRNA methyltransferase//NNMT/PNMT/TEMT family//Methyltransferase domain//Putative methyltransferase//Thiopurine S-methyltransferase (TPMT)//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Nodulation protein S (NodS)//Predicted AdoMet-dependent methyltransferase GO:0008033//GO:0006396//GO:0009312//GO:0006464//GO:0046500//GO:0006400//GO:0006479//GO:0009451//GO:0009877//GO:0008152 tRNA processing//RNA processing//oligosaccharide biosynthetic process//cellular protein modification process//S-adenosylmethionine metabolic process//tRNA modification//protein methylation//RNA modification//nodulation//metabolic process GO:0004809//GO:0008168//GO:0004719//GO:0008176//GO:0008173//GO:0008757//GO:0003723 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//RNA methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//RNA binding -- -- KOG1271 Methyltransferases Cluster-8309.27203 BF_2 41.81 2.32 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27204 BF_2 778.36 8.17 4274 282158073 NP_001164080.1 2197 4.9e-244 saxophone precursor [Tribolium castaneum] -- -- -- -- -- K04675 ACVR1, ALK2 activin receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04675 P80201 1388 1.3e-151 Activin receptor type-1 OS=Rattus norvegicus GN=Acvr1 PE=2 SV=1 PF07714//PF01064//PF00069//PF08515//PF00087 Protein tyrosine kinase//Activin types I and II receptor domain//Protein kinase domain//Transforming growth factor beta type I GS-motif//Snake toxin GO:0007178//GO:0009405//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//pathogenesis//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004675//GO:0004672 ATP binding//transmembrane receptor protein serine/threonine kinase activity//protein kinase activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.27208 BF_2 91.51 3.69 1325 270008647 EFA05095.1 862 9.5e-90 hypothetical protein TcasGA2_TC015194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 286 2.4e-24 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27209 BF_2 146.38 2.64 2611 270008906 EFA05354.1 2417 9.2e-270 hypothetical protein TcasGA2_TC015519 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2057 2.1e-229 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654//PF00087//PF02934 Voltage gated chloride channel//Snake toxin//GatB/GatE catalytic domain GO:0006821//GO:0009405//GO:0055085 chloride transport//pathogenesis//transmembrane transport GO:0016874//GO:0005247 ligase activity//voltage-gated chloride channel activity GO:0005576//GO:0016020 extracellular region//membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.27210 BF_2 169.52 1.25 5957 642920179 XP_008192235.1 324 1.0e-26 PREDICTED: uncharacterized protein LOC103312687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04976//PF14972 DMSO reductase anchor subunit (DmsC)//Mitochondrial morphogenesis regulator GO:0019645//GO:0007005 anaerobic electron transport chain//mitochondrion organization -- -- GO:0016021//GO:0031305 integral component of membrane//integral component of mitochondrial inner membrane -- -- Cluster-8309.27212 BF_2 94.33 1.76 2534 642931119 XP_008201669.1 700 1.1e-70 PREDICTED: autism susceptibility gene 2 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00376 MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.27214 BF_2 143.94 1.35 4748 642923524 XP_008193545.1 3325 0.0e+00 PREDICTED: anoctamin-5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q32M45 1455 2.4e-159 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.27215 BF_2 3003.00 38.15 3580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27217 BF_2 392.00 44.46 656 91088959 XP_973975.1 325 8.8e-28 PREDICTED: ragulator complex protein LAMTOR4 homolog [Tribolium castaneum]>gi|270012374|gb|EFA08822.1| hypothetical protein TcasGA2_TC006518 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VZL6 218 9.2e-17 Ragulator complex protein LAMTOR4 homolog OS=Drosophila melanogaster GN=CG14977 PE=1 SV=2 PF16672 Ragulator complex protein LAMTOR5 GO:0043154//GO:0043066//GO:0019079 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//negative regulation of apoptotic process//viral genome replication -- -- GO:0005737//GO:0071986 cytoplasm//Ragulator complex -- -- Cluster-8309.27218 BF_2 13.53 1.01 850 817208021 XP_012280005.1 250 5.6e-19 PREDICTED: ethanolamine kinase isoform X1 [Orussus abietinus]>gi|817208023|ref|XP_012280006.1| PREDICTED: ethanolamine kinase isoform X1 [Orussus abietinus]>gi|817208025|ref|XP_012280007.1| PREDICTED: ethanolamine kinase isoform X1 [Orussus abietinus]>gi|817208027|ref|XP_012280008.1| PREDICTED: ethanolamine kinase isoform X1 [Orussus abietinus] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 230 4.8e-18 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 PF17049//PF06008 ATPase expression protein 1//Laminin Domain I GO:0007165//GO:0030155//GO:0030334//GO:0006417//GO:0045995 signal transduction//regulation of cell adhesion//regulation of cell migration//regulation of translation//regulation of embryonic development GO:0005102//GO:0045182 receptor binding//translation regulator activity -- -- KOG4720 Ethanolamine kinase Cluster-8309.27220 BF_2 1101.40 18.80 2738 189237377 XP_971339.2 1363 1.6e-147 PREDICTED: X-linked interleukin-1 receptor accessory protein-like 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13591 158 3.5e-09 Neural cell adhesion molecule 1 OS=Homo sapiens GN=NCAM1 PE=1 SV=3 PF01582//PF13676//PF13895 TIR domain//TIR domain//Immunoglobulin domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.27221 BF_2 186.23 3.79 2345 270001585 EEZ98032.1 339 7.5e-29 hypothetical protein TcasGA2_TC000433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27222 BF_2 116.85 1.46 3635 642919133 XP_008191750.1 205 4.0e-13 PREDICTED: tetratricopeptide repeat protein 18-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03176//PF13414//PF02780//PF13181//PF12235 MMPL family//TPR repeat//Transketolase, C-terminal domain//Tetratricopeptide repeat//Fragile X-related 1 protein core C terminal GO:0008152 metabolic process GO:0005515//GO:0003723//GO:0003824 protein binding//RNA binding//catalytic activity GO:0016020 membrane -- -- Cluster-8309.27223 BF_2 214.98 3.25 3056 642919133 XP_008191750.1 395 3.1e-35 PREDICTED: tetratricopeptide repeat protein 18-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T0N1 173 7.1e-11 Cilia- and flagella-associated protein 70 OS=Homo sapiens GN=CFAP70 PE=2 SV=3 PF13414//PF03176//PF12235//PF02780//PF00515//PF13181 TPR repeat//MMPL family//Fragile X-related 1 protein core C terminal//Transketolase, C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0008152 metabolic process GO:0005515//GO:0003824//GO:0003723 protein binding//catalytic activity//RNA binding GO:0016020 membrane -- -- Cluster-8309.27226 BF_2 236.28 1.56 6627 642935213 XP_008199692.1 1371 4.5e-148 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X2 [Tribolium castaneum] 642935212 XM_008201470.1 619 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X2, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 1020 9.4e-109 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.27227 BF_2 512.96 3.10 7204 642935221 XP_008199697.1 1816 1.2e-199 PREDICTED: RNA-binding protein Musashi homolog Rbp6 isoform X6 [Tribolium castaneum] 642935220 XM_008201475.1 846 0 PREDICTED: Tribolium castaneum RNA-binding protein Musashi homolog Rbp6 (LOC656553), transcript variant X6, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 Q9VVE5 1513 7.0e-166 RNA-binding protein Musashi homolog Rbp6 OS=Drosophila melanogaster GN=Rbp6 PE=2 SV=3 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.27228 BF_2 81.14 0.59 5998 91078256 XP_970842.1 3273 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 558207907 XM_006132981.1 93 5.47081e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2064 7.4e-230 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF08506//PF05743//PF03810//PF05773 Cse1//UEV domain//Importin-beta N-terminal domain//RWD domain GO:0006886//GO:0015031//GO:0006464 intracellular protein transport//protein transport//cellular protein modification process GO:0008536//GO:0005515//GO:0008565 Ran GTPase binding//protein binding//protein transporter activity GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.27229 BF_2 644.75 5.09 5584 91078256 XP_970842.1 4504 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 558207907 XM_006132981.1 93 5.09092e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2891 0.0e+00 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF05743//PF05773//PF03810 UEV domain//RWD domain//Importin-beta N-terminal domain GO:0006886//GO:0015031//GO:0006464 intracellular protein transport//protein transport//cellular protein modification process GO:0005515//GO:0008536//GO:0008565 protein binding//Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.27230 BF_2 371.02 49.92 598 478257606 ENN77758.1 155 4.1e-08 hypothetical protein YQE_05730, partial [Dendroctonus ponderosae]>gi|546677510|gb|ERL88336.1| hypothetical protein D910_05723 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27233 BF_2 124.34 1.58 3582 642922865 XP_008200429.1 2031 7.2e-225 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum]>gi|642922867|ref|XP_008200430.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1465 1.3e-160 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF01926//PF13304//PF00664//PF12844//PF00236 Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Helix-turn-helix domain//Glycoprotein hormone GO:0055085//GO:0007165//GO:0006810 transmembrane transport//signal transduction//transport GO:0016887//GO:0043565//GO:0005525//GO:0042626//GO:0005524//GO:0003924//GO:0005179 ATPase activity//sequence-specific DNA binding//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.27237 BF_2 3.00 0.96 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27238 BF_2 43.83 0.72 2822 817087360 XP_012266451.1 2016 3.1e-223 PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae]>gi|817087362|ref|XP_012266452.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae] 158299880 XM_319893.4 460 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1902 2.1e-211 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF00270//PF00096//PF08168//PF06221//PF08057 DEAD/DEAH box helicase//Zinc finger, C2H2 type//NUC205 domain//Putative zinc finger motif, C2HC5-type//Erythromycin resistance leader peptide GO:0046677//GO:0006355 response to antibiotic//regulation of transcription, DNA-templated GO:0046872//GO:0003676//GO:0005524//GO:0008270 metal ion binding//nucleic acid binding//ATP binding//zinc ion binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.27239 BF_2 327.14 3.62 4072 642931762 XP_008196718.1 2808 0.0e+00 PREDICTED: exocyst complex component 7 [Tribolium castaneum]>gi|270011742|gb|EFA08190.1| hypothetical protein TcasGA2_TC005817 [Tribolium castaneum] -- -- -- -- -- K07195 EXOC7, EXO70 exocyst complex component 7 http://www.genome.jp/dbget-bin/www_bget?ko:K07195 Q9VSJ8 1391 5.5e-152 Exocyst complex component 7 OS=Drosophila melanogaster GN=exo70 PE=1 SV=2 PF00700//PF03081//PF02214//PF10392 Bacterial flagellin C-terminal helical region//Exo70 exocyst complex subunit//BTB/POZ domain//Golgi transport complex subunit 5 GO:0051260//GO:0071973//GO:0006891//GO:0006887 protein homooligomerization//bacterial-type flagellum-dependent cell motility//intra-Golgi vesicle-mediated transport//exocytosis GO:0005198 structural molecule activity GO:0000145//GO:0017119 exocyst//Golgi transport complex KOG1294 Apurinic/apyrimidinic endonuclease and related enzymes Cluster-8309.27240 BF_2 2.00 0.87 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27241 BF_2 131.52 4.60 1482 91078514 XP_969613.1 1034 1.2e-109 PREDICTED: mediator of RNA polymerase II transcription subunit 24 [Tribolium castaneum]>gi|270004025|gb|EFA00473.1| hypothetical protein TcasGA2_TC003332 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16X15 218 2.1e-16 Mediator of RNA polymerase II transcription subunit 24 OS=Aedes aegypti GN=MED24 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27245 BF_2 404.12 6.24 2997 478256729 ENN76910.1 1408 1.1e-152 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 436 2.2e-41 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF00083//PF04848 Major Facilitator Superfamily//Sugar (and other) transporter//Poxvirus A22 protein GO:0006310//GO:0006281//GO:0055085 DNA recombination//DNA repair//transmembrane transport GO:0000287//GO:0016788//GO:0022857//GO:0000400 magnesium ion binding//hydrolase activity, acting on ester bonds//transmembrane transporter activity//four-way junction DNA binding GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.27246 BF_2 1.00 6.07 247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27249 BF_2 2.00 0.53 446 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27250 BF_2 160.91 4.07 1943 642915754 XP_008200067.1 463 2.6e-43 PREDICTED: sprouty-related protein with EVH-1 domain isoform X1 [Tribolium castaneum] 642915753 XM_008201845.1 203 1.24369e-99 PREDICTED: Tribolium castaneum sprouty-related protein with EVH-1 domain (Spred), transcript variant X1, mRNA K04703 SPRED sprouty-related, EVH1 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04703 Q66JG9 272 1.5e-22 Sprouty-related, EVH1 domain-containing protein 1 OS=Xenopus tropicalis GN=spred1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27251 BF_2 97.00 3.90 1327 -- -- -- -- -- 689566069 LM032164.1 34 7.44694e-06 Soboliphyme baturini genome assembly S_baturini_Dall_Island ,scaffold SBAD_contig0003591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27252 BF_2 756.00 36.70 1149 91083777 XP_972333.1 572 3.5e-56 PREDICTED: mitochondrial fission 1 protein [Tribolium castaneum]>gi|270007915|gb|EFA04363.1| hypothetical protein TcasGA2_TC014659 [Tribolium castaneum] -- -- -- -- -- K17969 FIS1, TTC11, MDV2 mitochondrial fission 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K17969 Q9Y3D6 315 9.1e-28 Mitochondrial fission 1 protein OS=Homo sapiens GN=FIS1 PE=1 SV=2 PF09111 SLIDE GO:0006338 chromatin remodeling GO:0016818//GO:0005524//GO:0003676 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//nucleic acid binding GO:0005634 nucleus KOG3364 Membrane protein involved in organellar division Cluster-8309.27253 BF_2 17.77 0.99 1039 91090728 XP_966926.1 287 3.5e-23 PREDICTED: uncharacterized protein LOC655305 isoform X2 [Tribolium castaneum]>gi|270013951|gb|EFA10399.1| hypothetical protein TcasGA2_TC012638 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.27254 BF_2 157.56 7.96 1115 91090728 XP_966926.1 405 7.9e-37 PREDICTED: uncharacterized protein LOC655305 isoform X2 [Tribolium castaneum]>gi|270013951|gb|EFA10399.1| hypothetical protein TcasGA2_TC012638 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.27259 BF_2 117.12 16.90 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27261 BF_2 16.00 1.59 708 240999693 XP_002404773.1 836 5.3e-87 60S ribosomal protein L10A, putative [Ixodes scapularis]>gi|215491656|gb|EEC01297.1| 60S ribosomal protein L10A, putative [Ixodes scapularis] 195493604 XM_002094453.1 171 2.70166e-82 Drosophila yakuba GE21853 (Dyak\GE21853), partial mRNA K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q9VTP4 809 2.9e-85 60S ribosomal protein L10a-2 OS=Drosophila melanogaster GN=RpL10Ab PE=1 SV=2 PF08032 RNA 2'-O ribose methyltransferase substrate binding GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008168//GO:0003723//GO:0003735 methyltransferase activity//RNA binding//structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG1570 60S ribosomal protein L10A Cluster-8309.27264 BF_2 1291.46 8.25 6835 642935636 XP_008198092.1 4462 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 5.45165e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.0e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF00595//PF00620//PF13180//PF08718 PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//PDZ domain//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0051861//GO:0017089//GO:0005515 glycolipid binding//glycolipid transporter activity//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.27265 BF_2 371.66 12.21 1561 270001097 EEZ97544.1 1487 3.8e-162 hypothetical protein TcasGA2_TC011394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27267 BF_2 28.49 1.55 1058 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27268 BF_2 2.00 0.49 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27271 BF_2 5.70 0.35 968 189240236 XP_001811057.1 779 2.9e-80 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 53 1.47624e-16 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q7ZYD5 532 5.3e-53 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Xenopus laevis GN=slc25a25 PE=2 SV=1 PF00451 Scorpion short toxin, BmKK2 GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region KOG0036 Predicted mitochondrial carrier protein Cluster-8309.27273 BF_2 11.05 0.92 790 568259248 ETN67215.1 402 1.2e-36 hypothetical protein AND_000981 [Anopheles darlingi] 551493589 XM_005798306.1 116 1.13717e-51 PREDICTED: Xiphophorus maculatus calmodulin-like (LOC102227246), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 Q95NR9 369 3.4e-34 Calmodulin OS=Metridium senile PE=1 SV=3 PF12763//PF10591//PF13405//PF13833//PF13499//PF02627//PF13202//PF00036 Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF-hand domain pair//Carboxymuconolactone decarboxylase family//EF hand//EF hand GO:0055114//GO:0007165 oxidation-reduction process//signal transduction GO:0005515//GO:0051920//GO:0005509 protein binding//peroxiredoxin activity//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.27274 BF_2 24.00 0.71 1698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27277 BF_2 1.00 2.39 278 642919167 XP_008191765.1 166 1.0e-09 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27278 BF_2 1179.00 23.79 2360 91079354 XP_969967.1 2114 1.1e-234 PREDICTED: eukaryotic translation initiation factor 3 subunit E [Tribolium castaneum]>gi|270003495|gb|EEZ99942.1| hypothetical protein TcasGA2_TC002738 [Tribolium castaneum] 820854748 XM_012489206.1 281 6.61599e-143 PREDICTED: Apis florea eukaryotic translation initiation factor 3 subunit E (LOC100869754), transcript variant X2, mRNA K03250 EIF3E, INT6 translation initiation factor 3 subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K03250 Q2F5R8 1688 1.2e-186 Eukaryotic translation initiation factor 3 subunit E OS=Bombyx mori GN=eIF3-S6 PE=2 SV=1 PF01399 PCI domain GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003743 protein binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG2758 Translation initiation factor 3, subunit e (eIF-3e) Cluster-8309.27280 BF_2 27.32 0.64 2063 332376539 AEE63409.1 826 2.2e-85 unknown [Dendroctonus ponderosae]>gi|546672850|gb|ERL84577.1| hypothetical protein D910_02006 [Dendroctonus ponderosae] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 574 1.5e-57 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.27281 BF_2 78.00 7.45 725 817201979 XP_012276758.1 512 2.0e-49 PREDICTED: acyl-CoA Delta(11) desaturase-like isoform X2 [Orussus abietinus]>gi|817201981|ref|XP_012276759.1| PREDICTED: acyl-CoA Delta(11) desaturase-like isoform X2 [Orussus abietinus] -- -- -- -- -- K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q2KIA4 391 8.9e-37 Stearoyl-CoA desaturase 5 OS=Bos taurus GN=SCD5 PE=2 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-8309.27285 BF_2 1276.89 31.19 2000 91079642 XP_968121.1 1922 1.8e-212 PREDICTED: vacuolar protein sorting-associated protein 4B [Tribolium castaneum]>gi|270004475|gb|EFA00923.1| hypothetical protein TcasGA2_TC003829 [Tribolium castaneum] 346710885 AK385938.1 304 9.1602e-156 Bombyx mori mRNA, clone: fphe14F12 K12196 VPS4 vacuolar protein-sorting-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12196 Q9UN37 1614 3.7e-178 Vacuolar protein sorting-associated protein 4A OS=Homo sapiens GN=VPS4A PE=1 SV=1 PF07724//PF00004//PF04889//PF05496//PF00158//PF13304//PF06068//PF01695//PF14532//PF07728//PF00910//PF13414//PF02562//PF01637 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Cwf15/Cwc15 cell cycle control protein//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//TIP49 C-terminus//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//RNA helicase//TPR repeat//PhoH-like protein//Archaeal ATPase GO:0006310//GO:0006281//GO:0000398//GO:0006355 DNA recombination//DNA repair//mRNA splicing, via spliceosome//regulation of transcription, DNA-templated GO:0005515//GO:0003678//GO:0003723//GO:0017111//GO:0009378//GO:0003724//GO:0008134//GO:0005524//GO:0016887 protein binding//DNA helicase activity//RNA binding//nucleoside-triphosphatase activity//four-way junction helicase activity//RNA helicase activity//transcription factor binding//ATP binding//ATPase activity GO:0005681//GO:0005667//GO:0005657//GO:0009379 spliceosomal complex//transcription factor complex//replication fork//Holliday junction helicase complex KOG0739 AAA+-type ATPase Cluster-8309.27287 BF_2 1332.51 24.61 2552 270013489 EFA09937.1 457 1.7e-42 hypothetical protein TcasGA2_TC012090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02687//PF01284 FtsX-like permease family//Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.27288 BF_2 297.74 8.12 1822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27289 BF_2 43.02 0.50 3900 91079999 XP_966589.1 1804 1.7e-198 PREDICTED: kelch domain-containing protein 4 [Tribolium castaneum]>gi|270003222|gb|EEZ99669.1| hypothetical protein TcasGA2_TC002426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q921I2 1056 3.7e-113 Kelch domain-containing protein 4 OS=Mus musculus GN=Klhdc4 PE=2 SV=2 PF01344//PF00096//PF13465//PF07646//PF13912 Kelch motif//Zinc finger, C2H2 type//Zinc-finger double domain//Kelch motif//C2H2-type zinc finger -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- KOG1230 Protein containing repeated kelch motifs Cluster-8309.27290 BF_2 180.04 3.35 2535 642933271 XP_008197352.1 668 5.7e-67 PREDICTED: protein yippee-like 2 isoform X1 [Tribolium castaneum] 642933272 XM_961737.3 247 5.65728e-124 PREDICTED: Tribolium castaneum protein yippee-like 2 (LOC655221), transcript variant X2, mRNA -- -- -- -- Q65Z95 602 1.1e-60 Protein yippee-like 2 OS=Mus musculus GN=Ypel2 PE=2 SV=1 PF04777 Erv1 / Alr family GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.27292 BF_2 865.11 6.04 6283 189241493 XP_967027.2 4503 0.0e+00 PREDICTED: ras GTPase-activating protein 1 [Tribolium castaneum]>gi|270001192|gb|EEZ97639.1| hypothetical protein TcasGA2_TC016087 [Tribolium castaneum] -- -- -- -- -- K04352 RASA1, RASGAP Ras GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04352 P50904 2049 4.3e-228 Ras GTPase-activating protein 1 OS=Rattus norvegicus GN=Rasa1 PE=3 SV=1 PF14604//PF00018//PF00168//PF00616 Variant SH3 domain//SH3 domain//C2 domain//GTPase-activator protein for Ras-like GTPase GO:0051056//GO:0043547//GO:0043087 regulation of small GTPase mediated signal transduction//positive regulation of GTPase activity//regulation of GTPase activity GO:0005096//GO:0005543//GO:0005515 GTPase activator activity//phospholipid binding//protein binding GO:0005622 intracellular KOG3508 GTPase-activating protein Cluster-8309.27295 BF_2 1081.69 16.39 3048 642928336 XP_008195540.1 2691 1.8e-301 PREDICTED: slit homolog 1 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 294 6.6e-25 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27296 BF_2 8.00 1.59 498 -- -- -- -- -- 195964838 EU676338.1 96 9.17974e-41 Ocypode quadrata myosin heavy chain isoform 3 mRNA, partial cds -- -- -- -- -- -- -- -- PF00957//PF01576 Synaptobrevin//Myosin tail GO:0016192 vesicle-mediated transport GO:0003774 motor activity GO:0016021//GO:0016459 integral component of membrane//myosin complex -- -- Cluster-8309.27297 BF_2 85.51 0.93 4118 410509308 BAM65720.1 3886 0.0e+00 myosin heavy chain type 2 [Penaeus monodon] 343183154 AB613206.1 738 0 Marsupenaeus japonicus MYHb mRNA for myosin heavy chain type b, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 3776 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00612//PF01576//PF16716//PF00038 IQ calmodulin-binding motif//Myosin tail//Bone marrow stromal antigen 2//Intermediate filament protein GO:0051607 defense response to virus GO:0003774//GO:0005198//GO:0005515 motor activity//structural molecule activity//protein binding GO:0016459//GO:0005882 myosin complex//intermediate filament -- -- Cluster-8309.27298 BF_2 105.68 1.22 3898 410509308 BAM65720.1 3449 0.0e+00 myosin heavy chain type 2 [Penaeus monodon] 343183154 AB613206.1 552 0 Marsupenaeus japonicus MYHb mRNA for myosin heavy chain type b, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 3214 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF08702//PF00038//PF01576//PF00612//PF07926 Fibrinogen alpha/beta chain family//Intermediate filament protein//Myosin tail//IQ calmodulin-binding motif//TPR/MLP1/MLP2-like protein GO:0007165//GO:0051258//GO:0030168//GO:0006606 signal transduction//protein polymerization//platelet activation//protein import into nucleus GO:0005515//GO:0005198//GO:0003774//GO:0005102//GO:0030674 protein binding//structural molecule activity//motor activity//receptor binding//protein binding, bridging GO:0016459//GO:0005882//GO:0005577 myosin complex//intermediate filament//fibrinogen complex -- -- Cluster-8309.27299 BF_2 32.69 0.81 1981 410509312 BAM65722.1 1804 8.4e-199 myosin heavy chain type 2 [Litopenaeus vannamei] 37925238 AY232598.1 500 0 Homarus americanus slow muscle myosin S1 heavy chain mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1694 2.0e-187 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF06160//PF00523//PF08702//PF00038//PF04508//PF01576 Septation ring formation regulator, EzrA//Fusion glycoprotein F0//Fibrinogen alpha/beta chain family//Intermediate filament protein//Viral A-type inclusion protein repeat//Myosin tail GO:0000921//GO:0051258//GO:0016032//GO:0007165//GO:0006948//GO:0030168 septin ring assembly//protein polymerization//viral process//signal transduction//induction by virus of host cell-cell fusion//platelet activation GO:0005198//GO:0005102//GO:0003774//GO:0030674 structural molecule activity//receptor binding//motor activity//protein binding, bridging GO:0005940//GO:0005882//GO:0016459//GO:0016021//GO:0005577 septin ring//intermediate filament//myosin complex//integral component of membrane//fibrinogen complex -- -- Cluster-8309.27301 BF_2 27.45 0.41 3071 410509306 BAM65719.1 3021 0.0e+00 myosin heavy chain type 1 [Penaeus monodon] 37925238 AY232598.1 476 0 Homarus americanus slow muscle myosin S1 heavy chain mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2828 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF10473//PF12844//PF01576//PF00038 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Helix-turn-helix domain//Myosin tail//Intermediate filament protein -- -- GO:0003774//GO:0043565//GO:0042803//GO:0045502//GO:0008134//GO:0005198 motor activity//sequence-specific DNA binding//protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity GO:0005882//GO:0005667//GO:0030286//GO:0016459 intermediate filament//transcription factor complex//dynein complex//myosin complex -- -- Cluster-8309.27302 BF_2 36.54 0.55 3058 410509306 BAM65719.1 2901 0.0e+00 myosin heavy chain type 1 [Penaeus monodon] 107098391 DQ534441.1 268 1.44874e-135 Ocypode quadrata myosin heavy chain isoform 2 mRNA, partial cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2731 1.7e-307 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00038//PF05046//PF16716//PF01576//PF06160//PF10473//PF07926 Intermediate filament protein//Mitochondrial large subunit ribosomal protein (Img2)//Bone marrow stromal antigen 2//Myosin tail//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein GO:0006412//GO:0000921//GO:0051607//GO:0042254//GO:0006606 translation//septin ring assembly//defense response to virus//ribosome biogenesis//protein import into nucleus GO:0003774//GO:0042803//GO:0045502//GO:0008134//GO:0005198//GO:0003735 motor activity//protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity//structural constituent of ribosome GO:0005667//GO:0030286//GO:0005940//GO:0005882//GO:0016459//GO:0016021//GO:0005622//GO:0005840 transcription factor complex//dynein complex//septin ring//intermediate filament//myosin complex//integral component of membrane//intracellular//ribosome -- -- Cluster-8309.27306 BF_2 16.00 0.98 973 641672855 XP_008186090.1 179 1.1e-10 PREDICTED: transcription factor IIIA-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02701//PF13465//PF00096//PF05191 Dof domain, zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate kinase, active site lid GO:0006144//GO:0046034//GO:0006355 purine nucleobase metabolic process//ATP metabolic process//regulation of transcription, DNA-templated GO:0004017//GO:0046872//GO:0003677 adenylate kinase activity//metal ion binding//DNA binding -- -- -- -- Cluster-8309.27307 BF_2 907.44 38.39 1276 478262967 ENN81373.1 902 2.1e-94 hypothetical protein YQE_02190, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O16098 167 1.5e-10 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128 Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169 catalytic activity//cation binding -- -- -- -- Cluster-8309.2731 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27310 BF_2 684.00 28.00 1309 91080019 XP_971957.1 514 2.1e-49 PREDICTED: uncharacterized protein LOC660651 isoform X1 [Tribolium castaneum]>gi|270003229|gb|EEZ99676.1| hypothetical protein TcasGA2_TC002433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00669//PF05051 Bacterial flagellin N-terminal helical region//Cytochrome C oxidase copper chaperone (COX17) GO:0006825//GO:0071973 copper ion transport//bacterial-type flagellum-dependent cell motility GO:0005198//GO:0016531//GO:0005507 structural molecule activity//copper chaperone activity//copper ion binding GO:0005758 mitochondrial intermembrane space -- -- Cluster-8309.27312 BF_2 33.43 0.70 2281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27314 BF_2 129.05 0.94 6042 642911239 XP_008199721.1 3695 0.0e+00 PREDICTED: IQ motif and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 641661643 XM_001945108.3 182 1.84679e-87 PREDICTED: Acyrthosiphon pisum IQ motif and SEC7 domain-containing protein 1 (LOC100162626), transcript variant X2, mRNA K12495 IQSEC IQ motif and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12495 Q6DN90 1182 1.4e-127 IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens GN=IQSEC1 PE=1 SV=1 PF01369//PF00612 Sec7 domain//IQ calmodulin-binding motif GO:0043087//GO:0032012 regulation of GTPase activity//regulation of ARF protein signal transduction GO:0005515//GO:0005086 protein binding//ARF guanyl-nucleotide exchange factor activity -- -- KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain Cluster-8309.27320 BF_2 423.00 7.65 2599 642933929 XP_008197571.1 903 3.3e-94 PREDICTED: nucleotide exchange factor SIL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUA7 500 7.3e-49 Nucleotide exchange factor SIL1 OS=Xenopus laevis GN=sil1 PE=2 SV=1 PF12422//PF10389//PF11698//PF05479 Condensin II non structural maintenance of chromosomes subunit//Bacteriophage coat protein B//V-ATPase subunit H//Photosystem I reaction centre subunit N (PSAN or PSI-N) GO:0015979//GO:0015991 photosynthesis//ATP hydrolysis coupled proton transport GO:0005516//GO:0016820 calmodulin binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0019028//GO:0005634//GO:0042651//GO:0009522//GO:0000221 viral capsid//nucleus//thylakoid membrane//photosystem I//vacuolar proton-transporting V-type ATPase, V1 domain KOG2160 Armadillo/beta-catenin-like repeat-containing protein Cluster-8309.27323 BF_2 596.54 11.98 2370 817084932 XP_012265132.1 661 3.5e-66 PREDICTED: protein SPT2 homolog [Athalia rosae] -- -- -- -- -- K15193 SPTY2D1, SPT2 protein SPT2 http://www.genome.jp/dbget-bin/www_bget?ko:K15193 Q8IMP6 227 3.0e-17 Protein SPT2 homolog OS=Drosophila melanogaster GN=CG5815 PE=1 SV=1 PF11648 C-terminal domain of RIG-I -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.27325 BF_2 15.41 0.70 1208 91092542 XP_968010.1 1126 2.1e-120 PREDICTED: nucleoporin Nup43 [Tribolium castaneum]>gi|270006621|gb|EFA03069.1| hypothetical protein TcasGA2_TC010925 [Tribolium castaneum] -- -- -- -- -- K14305 NUP43 nuclear pore complex protein Nup43 http://www.genome.jp/dbget-bin/www_bget?ko:K14305 Q8NFH3 546 1.6e-54 Nucleoporin Nup43 OS=Homo sapiens GN=NUP43 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27327 BF_2 28.14 1.13 1328 91093034 XP_970412.1 832 2.9e-86 PREDICTED: transmembrane protein 183 [Tribolium castaneum]>gi|270002700|gb|EEZ99147.1| hypothetical protein TcasGA2_TC012928 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXX5 362 3.7e-33 Transmembrane protein 183A OS=Homo sapiens GN=TMEM183A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27330 BF_2 242.01 7.61 1617 478257843 ENN77986.1 1014 2.8e-107 hypothetical protein YQE_05661, partial [Dendroctonus ponderosae] -- -- -- -- -- K00683 QPCT glutaminyl-peptide cyclotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00683 Q28120 632 2.2e-64 Glutaminyl-peptide cyclotransferase OS=Bos taurus GN=QPCT PE=1 SV=1 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG3946 Glutaminyl cyclase Cluster-8309.27331 BF_2 450.13 11.31 1952 478257843 ENN77986.1 1016 2.0e-107 hypothetical protein YQE_05661, partial [Dendroctonus ponderosae] -- -- -- -- -- K00683 QPCT glutaminyl-peptide cyclotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00683 Q28120 632 2.7e-64 Glutaminyl-peptide cyclotransferase OS=Bos taurus GN=QPCT PE=1 SV=1 PF05450 Nicastrin GO:0016485 protein processing -- -- GO:0016021 integral component of membrane KOG3946 Glutaminyl cyclase Cluster-8309.27335 BF_2 69.52 0.52 5844 350414142 XP_003490218.1 2125 1.5e-235 PREDICTED: protein O-GlcNAcase isoform X3 [Bombus impatiens] 830022072 XM_012723671.1 44 9.23924e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 3.7e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF05418//PF09726//PF00736//PF06331//PF13673 Apovitellenin I (Apo-VLDL-II)//Transmembrane protein//EF-1 guanine nucleotide exchange domain//Transcription factor TFIIH complex subunit Tfb5//Acetyltransferase (GNAT) domain GO:0006355//GO:0006289//GO:0006414//GO:0006448//GO:0042967//GO:0006629 regulation of transcription, DNA-templated//nucleotide-excision repair//translational elongation//regulation of translational elongation//acyl-carrier-protein biosynthetic process//lipid metabolic process GO:0003746//GO:0008080//GO:0004857 translation elongation factor activity//N-acetyltransferase activity//enzyme inhibitor activity GO:0005853//GO:0005840//GO:0042627//GO:0000439//GO:0016021 eukaryotic translation elongation factor 1 complex//ribosome//chylomicron//core TFIIH complex//integral component of membrane KOG3698 Hyaluronoglucosaminidase Cluster-8309.27337 BF_2 66.75 1.53 2117 642920122 XP_008192215.1 371 1.3e-32 PREDICTED: microtubule-associated protein futsch isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00444 Ribosomal protein L36 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.27339 BF_2 201.00 5.18 1909 642924770 XP_008194433.1 1820 1.1e-200 PREDICTED: netrin receptor UNC5C isoform X1 [Tribolium castaneum] -- -- -- -- -- K07521 UNC5 netrin receptor unc-5 http://www.genome.jp/dbget-bin/www_bget?ko:K07521 Q8K1S4 563 2.7e-56 Netrin receptor UNC5A OS=Mus musculus GN=Unc5a PE=2 SV=1 PF01754//PF00531 A20-like zinc finger//Death domain GO:0007165 signal transduction GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding -- -- KOG1480 Netrin transmembrane receptor unc-5 Cluster-8309.27342 BF_2 21.86 0.33 3065 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.27343 BF_2 369.78 3.92 4229 91079776 XP_967502.1 1323 1.1e-142 PREDICTED: coiled-coil domain-containing protein 50 [Tribolium castaneum]>gi|270004516|gb|EFA00964.1| hypothetical protein TcasGA2_TC003874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IVM0 183 6.8e-12 Coiled-coil domain-containing protein 50 OS=Homo sapiens GN=CCDC50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27345 BF_2 9.26 0.64 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27346 BF_2 3.05 0.31 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27347 BF_2 55.01 1.02 2539 642927010 XP_008195102.1 614 1.0e-60 PREDICTED: calcium-independent phospholipase A2-gamma-like [Tribolium castaneum] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q9NP80 359 1.6e-32 Calcium-independent phospholipase A2-gamma OS=Homo sapiens GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.27348 BF_2 156.44 6.00 1378 642926052 XP_970129.2 648 6.5e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 207 3.7e-15 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27352 BF_2 24.00 0.79 1558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27355 BF_2 1087.33 32.24 1698 91081049 XP_976170.1 580 6.1e-57 PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920368|ref|XP_008192316.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920370|ref|XP_008192317.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920372|ref|XP_008192318.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|642920374|ref|XP_008192319.1| PREDICTED: uncharacterized protein LOC664274 [Tribolium castaneum]>gi|270005238|gb|EFA01686.1| hypothetical protein TcasGA2_TC007261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27356 BF_2 35.00 1.08 1644 642930560 XP_008198137.1 285 9.6e-23 PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930562|ref|XP_008198139.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930564|ref|XP_008198145.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930566|ref|XP_008198152.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum]>gi|642930568|ref|XP_008198158.1| PREDICTED: uncharacterized protein LOC103314287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27357 BF_2 21.82 1.01 1190 270006529 EFA02977.1 744 4.1e-76 hypothetical protein TcasGA2_TC030780 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64676 214 4.9e-16 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Mus musculus GN=Ugt8 PE=2 SV=2 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.27359 BF_2 987.04 29.25 1699 568599608 AHE13799.1 269 7.1e-21 odorant binding protein [Lissorhoptrus oryzophilus] -- -- -- -- -- -- -- -- -- Q27017 158 2.2e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.27360 BF_2 124.00 35.43 433 363498188 AEW24506.1 149 1.5e-07 Kazal-type protease inhibitor [Eriocheir sinensis] -- -- -- -- -- -- -- -- -- P0DKT1 145 1.8e-08 Turripeptide Pal9.2 OS=Polystira albida PE=2 SV=1 PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27361 BF_2 25.98 0.45 2729 91089737 XP_975124.1 1653 3.7e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.6e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF04506//PF01384 Rft protein//Phosphate transporter family GO:0006869//GO:0006817 lipid transport//phosphate ion transport GO:0005315//GO:0005319 inorganic phosphate transmembrane transporter activity//lipid transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.27363 BF_2 27.47 0.48 2671 478257449 ENN77605.1 1171 2.8e-125 hypothetical protein YQE_05900, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 553 5.4e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228 Stage II sporulation protein E (SpoIIE) -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.27365 BF_2 4.23 0.42 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27366 BF_2 46.27 1.44 1633 642939355 XP_008197126.1 746 3.3e-76 PREDICTED: N(6)-adenine-specific DNA methyltransferase 2 [Tribolium castaneum]>gi|270016449|gb|EFA12895.1| hypothetical protein TcasGA2_TC004409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKT6 583 1.1e-58 Protein-lysine N-methyltransferase N6AMT2 OS=Gallus gallus GN=N6AMT2 PE=2 SV=1 PF10237//PF03602 Probable N6-adenine methyltransferase//Conserved hypothetical protein 95 GO:0031167//GO:0032259 rRNA methylation//methylation GO:0003676//GO:0008168 nucleic acid binding//methyltransferase activity -- -- KOG3350 Uncharacterized conserved protein Cluster-8309.27367 BF_2 281.09 6.39 2128 642939351 XP_008197109.1 761 7.9e-78 PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum]>gi|642939353|ref|XP_008197119.1| PREDICTED: uncharacterized protein LOC103314056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27368 BF_2 106.00 3.33 1619 642937257 XP_008198759.1 1340 4.4e-145 PREDICTED: serine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270001083|gb|EEZ97530.1| hypothetical protein TcasGA2_TC011377 [Tribolium castaneum] -- -- -- -- -- K01875 SARS, serS seryl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01875 Q9NP81 816 1.0e-85 Serine--tRNA ligase, mitochondrial OS=Homo sapiens GN=SARS2 PE=1 SV=1 PF00587//PF03260 tRNA synthetase class II core domain (G, H, P, S and T)//Lepidopteran low molecular weight (30 kD) lipoprotein GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding GO:0005576 extracellular region KOG2509 Seryl-tRNA synthetase Cluster-8309.27370 BF_2 1032.00 27.71 1845 91085765 XP_974179.1 1335 1.9e-144 PREDICTED: F-actin-capping protein subunit alpha [Tribolium castaneum]>gi|270009998|gb|EFA06446.1| hypothetical protein TcasGA2_TC009328 [Tribolium castaneum] -- -- -- -- -- K10364 CAPZA capping protein (actin filament) muscle Z-line, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10364 Q9W2N0 1129 6.0e-122 F-actin-capping protein subunit alpha OS=Drosophila melanogaster GN=cpa PE=2 SV=1 PF01267 F-actin capping protein alpha subunit GO:0051016//GO:0030036 barbed-end actin filament capping//actin cytoskeleton organization GO:0003779 actin binding GO:0008290 F-actin capping protein complex KOG0836 F-actin capping protein, alpha subunit Cluster-8309.27371 BF_2 14.00 1.25 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27372 BF_2 154.63 1.26 5401 642935917 XP_008198228.1 1808 7.9e-199 PREDICTED: dual specificity protein phosphatase Mpk3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9VVW5 860 2.7e-90 Dual specificity protein phosphatase Mpk3 OS=Drosophila melanogaster GN=Mkp3 PE=1 SV=2 PF04179//PF00782//PF05706//PF00102 Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0019988//GO:0006570//GO:0006470 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0004721//GO:0008138//GO:0043399 protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity -- -- KOG1717 Dual specificity phosphatase Cluster-8309.27374 BF_2 1996.66 11.79 7373 642929628 XP_008195910.1 1232 6.6e-132 PREDICTED: integrin alpha-X-like [Tribolium castaneum] -- -- -- -- -- K06585 ITGA9 integrin alpha 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06585 O44386 633 7.8e-64 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.27376 BF_2 118.39 2.64 2164 642911000 XP_008193502.1 296 6.7e-24 PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum]>gi|642911002|ref|XP_008193503.1| PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05019//PF00191//PF16113 Coenzyme Q (ubiquinone) biosynthesis protein Coq4//Annexin//Enoyl-CoA hydratase/isomerase GO:0006744 ubiquinone biosynthetic process GO:0005544//GO:0016836//GO:0005509 calcium-dependent phospholipid binding//hydro-lyase activity//calcium ion binding -- -- -- -- Cluster-8309.27377 BF_2 912.44 13.97 3019 646694595 KDR08043.1 2640 1.5e-295 hypothetical protein L798_02197 [Zootermopsis nevadensis] 808134796 XM_003399528.2 277 1.41996e-140 PREDICTED: Bombus terrestris uncharacterized LOC100647816 (LOC100647816), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27379 BF_2 119.36 35.30 428 817055776 XP_012268719.1 727 1.4e-74 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X2 [Athalia rosae] 665820405 XM_008560879.1 158 2.6691e-75 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 580 6.3e-59 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27380 BF_2 30.60 1.73 1026 746851175 XP_011056100.1 720 2.2e-73 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X4 [Acromyrmex echinatior] 268574973 XM_002642420.1 87 1.97163e-35 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 601 5.6e-61 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01517//PF16326//PF04111//PF01496//PF00769 Hepatitis delta virus delta antigen//ABC transporter C-terminal domain//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Ezrin/radixin/moesin family GO:0015992//GO:0015991//GO:0006914 proton transport//ATP hydrolysis coupled proton transport//autophagy GO:0015078//GO:0003677//GO:0003723//GO:0008092 hydrogen ion transmembrane transporter activity//DNA binding//RNA binding//cytoskeletal protein binding GO:0005737//GO:0033179//GO:0042025//GO:0019898 cytoplasm//proton-transporting V-type ATPase, V0 domain//host cell nucleus//extrinsic component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27381 BF_2 1566.96 42.49 1830 546681043 ERL91208.1 2252 8.7e-251 hypothetical protein D910_08546 [Dendroctonus ponderosae] 820861306 XM_012491990.1 156 1.56803e-73 PREDICTED: Apis florea V-type proton ATPase 116 kDa subunit a isoform 1-like (LOC100868664), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q29466 1515 1.0e-166 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Bos taurus GN=ATP6V0A1 PE=2 SV=1 PF01496 V-type ATPase 116kDa subunit family GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27382 BF_2 70.88 0.74 4309 642912101 XP_008200805.1 862 3.1e-89 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [Tribolium castaneum] 665820405 XM_008560879.1 190 4.69234e-92 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 604 1.1e-60 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27383 BF_2 4.23 0.78 513 768421708 XP_011551676.1 702 1.3e-71 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1-like [Plutella xylostella] 665820405 XM_008560879.1 157 1.16376e-74 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 561 1.2e-56 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27384 BF_2 57.84 0.47 5382 512921142 XP_004929807.1 2290 1.0e-254 PREDICTED: bestrophin-4 isoform X2 [Bombyx mori] 644995962 XM_001603356.3 234 2.03808e-116 PREDICTED: Nasonia vitripennis putative lysozyme-like protein (LOC100119673), transcript variant X1, mRNA -- -- -- -- Q6H1V1 898 1.1e-94 Bestrophin-3 OS=Mus musculus GN=Best3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.27385 BF_2 317.05 15.16 1162 749733307 XP_011145187.1 1537 4.5e-168 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X3 [Harpegnathos saltator] 665820405 XM_008560879.1 345 8.48578e-179 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 1199 2.9e-130 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF04111//PF03938//PF01517//PF01496 Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Hepatitis delta virus delta antigen//V-type ATPase 116kDa subunit family GO:0006914//GO:0015991//GO:0015992 autophagy//ATP hydrolysis coupled proton transport//proton transport GO:0003723//GO:0051082//GO:0015078 RNA binding//unfolded protein binding//hydrogen ion transmembrane transporter activity GO:0042025//GO:0033179 host cell nucleus//proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27387 BF_2 41.59 12.30 428 332374848 AEE62565.1 739 5.6e-76 unknown [Dendroctonus ponderosae] 665820405 XM_008560879.1 157 9.59979e-75 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 561 1.0e-56 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.27388 BF_2 68.39 0.49 6069 373159261 AEY63780.1 2465 5.8e-275 ecdysone receptor isoform A [Monochamus alternatus] 373159260 JN616374.1 1387 0 Monochamus alternatus ecdysone receptor isoform A mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1354 1.6e-147 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.27390 BF_2 573.27 14.47 1944 91077186 XP_972614.1 1315 4.2e-142 PREDICTED: cyclin-K [Tribolium castaneum]>gi|270001704|gb|EEZ98151.1| hypothetical protein TcasGA2_TC000577 [Tribolium castaneum] 766919740 XM_011506006.1 277 9.09003e-141 PREDICTED: Ceratosolen solmsi marchali cyclin-K (LOC105367338), transcript variant X2, mRNA -- -- -- -- O75909 990 8.3e-106 Cyclin-K OS=Homo sapiens GN=CCNK PE=1 SV=2 PF02984 Cyclin, C-terminal domain GO:0000079//GO:0006355 regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0005634 nucleus KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.27394 BF_2 8.90 0.35 1353 91077326 XP_974776.1 962 2.5e-101 PREDICTED: pyrroline-5-carboxylate reductase 3 [Tribolium castaneum]>gi|270001668|gb|EEZ98115.1| hypothetical protein TcasGA2_TC000533 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q5SPD7 558 7.1e-56 Pyrroline-5-carboxylate reductase 3 OS=Danio rerio GN=pycrl PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0019521//GO:0006561//GO:0006098//GO:0006525 oxidation-reduction process//D-gluconate metabolic process//proline biosynthetic process//pentose-phosphate shunt//arginine metabolic process GO:0000166//GO:0004616//GO:0004735 nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity//pyrroline-5-carboxylate reductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.27395 BF_2 623.67 15.34 1988 91091868 XP_969098.1 1588 9.4e-174 PREDICTED: 26S proteasome non-ATPase regulatory subunit 5 [Tribolium castaneum]>gi|270001117|gb|EEZ97564.1| hypothetical protein TcasGA2_TC011419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16401 742 4.8e-77 26S proteasome non-ATPase regulatory subunit 5 OS=Homo sapiens GN=PSMD5 PE=1 SV=3 PF02985//PF10508//PF11698//PF00514 HEAT repeat//Proteasome non-ATPase 26S subunit//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015991//GO:0043248 ATP hydrolysis coupled proton transport//proteasome assembly GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.27398 BF_2 91.97 0.70 5792 642918795 XP_008191588.1 293 4.0e-23 PREDICTED: uncharacterized protein LOC103312529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27399 BF_2 21.59 0.42 2438 642936610 XP_008198505.1 266 2.3e-20 PREDICTED: uncharacterized protein LOC661523 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27401 BF_2 385.00 25.17 927 91077738 XP_975157.1 534 7.2e-52 PREDICTED: prefoldin subunit 2 [Tribolium castaneum]>gi|270001520|gb|EEZ97967.1| hypothetical protein TcasGA2_TC000359 [Tribolium castaneum] -- -- -- -- -- K09549 PFDN2 prefoldin subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09549 A1A4P5 349 8.4e-32 Prefoldin subunit 2 OS=Bos taurus GN=PFDN2 PE=2 SV=1 PF01920 Prefoldin subunit GO:0006457 protein folding GO:0051082 unfolded protein binding GO:0016272 prefoldin complex KOG4098 Molecular chaperone Prefoldin, subunit 2 Cluster-8309.27402 BF_2 20.87 0.50 2020 91086011 XP_972761.1 2152 3.8e-239 PREDICTED: uncharacterized protein LOC661513 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.27404 BF_2 594.55 36.91 961 642939160 XP_969591.2 809 9.7e-84 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 624 1.1e-63 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.27405 BF_2 149.34 0.65 9956 478250015 ENN70521.1 4003 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 573901209 XM_006638269.1 121 2.47672e-53 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2864 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF06414//PF00063//PF00612//PF06017//PF00437 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0005524//GO:0003774//GO:0016301//GO:0005515 ATP binding//motor activity//kinase activity//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.27406 BF_2 1104.91 4.84 9845 478250015 ENN70521.1 4003 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 573901209 XM_006638269.1 121 2.449e-53 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2864 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF06414//PF00063//PF00612//PF06017//PF00437 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0005515//GO:0016301//GO:0003774//GO:0005524 protein binding//kinase activity//motor activity//ATP binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.27408 BF_2 68.10 0.98 3209 546682308 ERL92261.1 525 2.8e-50 hypothetical protein D910_09578, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y530 373 4.8e-34 O-acetyl-ADP-ribose deacetylase 1 OS=Homo sapiens GN=OARD1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27409 BF_2 851.02 4.56 8086 642936743 XP_008198562.1 5262 0.0e+00 PREDICTED: neurexin-4 isoform X1 [Tribolium castaneum] 662206951 XM_008478733.1 135 3.31584e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 4430 0.0e+00 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF03079//PF01106//PF00008//PF01648 ARD/ARD' family//NifU-like domain//EGF-like domain//4'-phosphopantetheinyl transferase superfamily GO:0055114//GO:0015940//GO:0016226 oxidation-reduction process//pantothenate biosynthetic process//iron-sulfur cluster assembly GO:0005506//GO:0000287//GO:0051536//GO:0008897//GO:0005515//GO:0010309 iron ion binding//magnesium ion binding//iron-sulfur cluster binding//holo-[acyl-carrier-protein] synthase activity//protein binding//acireductone dioxygenase [iron(II)-requiring] activity -- -- -- -- Cluster-8309.27413 BF_2 9.40 0.51 1059 270001667 EEZ98114.1 763 2.3e-78 hypothetical protein TcasGA2_TC000532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15757 Amelotin GO:0070175//GO:0042475 positive regulation of enamel mineralization//odontogenesis of dentin-containing tooth -- -- -- -- -- -- Cluster-8309.27414 BF_2 17.61 0.64 1437 91081511 XP_974643.1 780 3.3e-80 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 Q9JHW5 613 3.2e-62 Vesicle-associated membrane protein 7 OS=Rattus norvegicus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.27415 BF_2 23.00 1.41 968 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27416 BF_2 102.74 2.82 1813 642938101 XP_008199656.1 197 1.7e-12 PREDICTED: THAP domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.27417 BF_2 607.54 11.92 2419 100811805 BAE94685.1 2512 8.2e-281 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 754 2.4e-78 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.27418 BF_2 76.00 0.75 4546 805752828 XP_012154051.1 3786 0.0e+00 PREDICTED: alpha-actinin, sarcomeric isoform X2 [Megachile rotundata] 442614869 NM_001201604.2 882 0 Drosophila melanogaster alpha actinin (Actn), transcript variant I, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 3704 0.0e+00 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 PF00307//PF07934//PF13499//PF00296//PF00036//PF13405//PF00435 Calponin homology (CH) domain//8-oxoguanine DNA glycosylase, N-terminal domain//EF-hand domain pair//Luciferase-like monooxygenase//EF hand//EF-hand domain//Spectrin repeat GO:0006308//GO:0006289//GO:0055114//GO:0006285//GO:0006281 DNA catabolic process//nucleotide-excision repair//oxidation-reduction process//base-excision repair, AP site formation//DNA repair GO:0003684//GO:0008534//GO:0005509//GO:0005515//GO:0016705 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//calcium ion binding//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.27419 BF_2 239.98 2.61 4138 642922642 XP_008193259.1 3159 0.0e+00 PREDICTED: zinc finger protein ush isoform X1 [Tribolium castaneum] -- -- -- -- -- K17441 ZFPM1, FOG1 zinc finger protein ZFPM1 http://www.genome.jp/dbget-bin/www_bget?ko:K17441 Q9VPQ6 831 4.8e-87 Zinc finger protein ush OS=Drosophila melanogaster GN=ush PE=1 SV=2 PF05221//PF16622//PF00096//PF13465 S-adenosyl-L-homocysteine hydrolase//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006555//GO:0006730 methionine metabolic process//one-carbon metabolic process GO:0004013//GO:0046872 adenosylhomocysteinase activity//metal ion binding -- -- -- -- Cluster-8309.27420 BF_2 547.00 18.50 1524 642928714 XP_973858.2 1169 2.8e-125 PREDICTED: venom serine protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQS8 716 3.8e-74 Venom serine protease 34 OS=Apis mellifera PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.27422 BF_2 32.00 3.70 649 459353537 AGG55290.1 798 1.2e-82 ribosomal protein L18 [Litopenaeus vannamei] 612061316 XM_007506695.1 40 1.63812e-09 PREDICTED: Monodelphis domestica ribosomal protein L18 (RPL18), mRNA K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q4GXG7 731 3.0e-76 60S ribosomal protein L18 OS=Timarcha balearica GN=RpL18 PE=2 SV=1 PF05039 Agouti protein GO:0009755 hormone-mediated signaling pathway -- -- GO:0005576 extracellular region KOG1714 60s ribosomal protein L18 Cluster-8309.27423 BF_2 277.42 2.22 5526 642935794 XP_008198177.1 369 5.9e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335//PF00864 Tetraspanin family//ATP P2X receptor GO:0007165//GO:0098655//GO:0033198//GO:0006812 signal transduction//cation transmembrane transport//response to ATP//cation transport GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane -- -- Cluster-8309.27425 BF_2 139.88 7.33 1085 91093429 XP_968933.1 554 4.1e-54 PREDICTED: uncharacterized protein LOC657376 [Tribolium castaneum]>gi|270015461|gb|EFA11909.1| hypothetical protein TcasGA2_TC004066 [Tribolium castaneum] -- -- -- -- -- K18157 TMEM126A transmembrane protein 126A http://www.genome.jp/dbget-bin/www_bget?ko:K18157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27426 BF_2 63.76 0.53 5363 546678750 ERL89302.1 1357 1.5e-146 hypothetical protein D910_06674 [Dendroctonus ponderosae] -- -- -- -- -- K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 -- -- -- -- PF12106//PF05656 Colicin C terminal ribonuclease domain//Protein of unknown function (DUF805) GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.27430 BF_2 1.91 0.41 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27431 BF_2 6.00 0.88 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27433 BF_2 43.82 0.57 3506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04573//PF00651 Signal peptidase subunit//BTB/POZ domain GO:0006465 signal peptide processing GO:0008233//GO:0005515 peptidase activity//protein binding GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.27434 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27435 BF_2 1088.88 33.16 1661 642930353 XP_008196361.1 1876 3.1e-207 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] 642930352 XM_008198139.1 476 0 PREDICTED: Tribolium castaneum protein 4.1 homolog (LOC662229), transcript variant X3, mRNA K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1380 4.2e-151 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27437 BF_2 13.71 0.34 1996 478255350 ENN75576.1 697 2.0e-70 hypothetical protein YQE_07919, partial [Dendroctonus ponderosae] -- -- -- -- -- K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q9VSD7 509 5.1e-50 Lariat debranching enzyme OS=Drosophila melanogaster GN=ldbr PE=1 SV=1 PF05011 Lariat debranching enzyme, C-terminal domain GO:0006397 mRNA processing GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2863 RNA lariat debranching enzyme Cluster-8309.27438 BF_2 348.92 2.35 6501 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.27441 BF_2 10.00 0.48 1154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27442 BF_2 45.39 0.39 5190 642920483 XP_008192370.1 2537 2.2e-283 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 3.3e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF02601//PF01496//PF07647//PF00536//PF02198//PF01763 Exonuclease VII, large subunit//V-type ATPase 116kDa subunit family//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain//Herpesvirus UL6 like GO:0006308//GO:0015992//GO:0006323//GO:0015991 DNA catabolic process//proton transport//DNA packaging//ATP hydrolysis coupled proton transport GO:0015078//GO:0043565//GO:0005515//GO:0008855 hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0033179//GO:0005634 exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.27449 BF_2 133.65 3.31 1977 91094295 XP_971662.1 1667 6.4e-183 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 1449 5.0e-159 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF00441//PF02770//PF02771 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0006118//GO:0008152 oxidation-reduction process//obsolete electron transport//metabolic process GO:0016627//GO:0003995//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.27452 BF_2 145.00 3.40 2069 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27455 BF_2 49.45 0.49 4504 780649216 XP_011689959.1 1096 2.4e-116 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00589 Phage integrase family GO:0015074//GO:0006310 DNA integration//DNA recombination GO:0003677 DNA binding -- -- -- -- Cluster-8309.27462 BF_2 233.00 2.46 4254 821489447 XP_012407072.1 842 6.4e-87 PREDICTED: zinc finger protein 420-like [Sarcophilus harrisii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZN57 809 1.8e-84 Zinc finger protein 2 homolog OS=Homo sapiens GN=ZFP2 PE=1 SV=1 PF00076//PF13465//PF16622//PF00641//PF13912//PF00096//PF07776//PF01585 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc-finger double domain//zinc-finger C2H2-type//Zn-finger in Ran binding protein and others//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//G-patch domain -- -- GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.27463 BF_2 130.00 2.50 2464 571032322 AHF21599.1 687 3.5e-69 NADH dehydrogenase subunit 1 (mitochondrion) [Allothyrus sp. LamingtonNP-QMS95173] 255959120 FJ802461.1 117 1.01554e-51 Thrinaconyx fumosus isolate MN046 NADH dehydrogenase subunit 4 (ND4) gene, partial cds; mitochondrial >gnl|BL_ORD_ID|8200935 Thrinaconyx fumosus isolate MN086 NADH dehydrogenase subunit 4 (ND4) gene, partial cds; mitochondrial K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 B0FWD8 608 2.1e-61 NADH-ubiquinone oxidoreductase chain 1 OS=Aedes aegypti GN=mt:ND1 PE=3 SV=1 PF01059//PF00420//PF00146 NADH-ubiquinone oxidoreductase chain 4, amino terminus//NADH-ubiquinone/plastoquinone oxidoreductase chain 4L//NADH dehydrogenase GO:0042773//GO:0006120//GO:0055114 ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0016020 membrane KOG4845 NADH dehydrogenase, subunit 4 Cluster-8309.27465 BF_2 40.34 0.44 4166 642914654 XP_008190301.1 994 1.5e-104 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 8.49872e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 3.7e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170//PF03131 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.27466 BF_2 163.18 1.93 3828 91082137 XP_966595.1 1646 3.4e-180 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 178 1.95114e-85 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1351 2.3e-147 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.27469 BF_2 924.83 8.41 4888 270003267 EEZ99714.1 1734 2.7e-190 hypothetical protein TcasGA2_TC002475 [Tribolium castaneum] 642918335 XM_008198635.1 172 5.40409e-82 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tricorner (LOC655192), mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q2LZZ7 1573 5.2e-173 Serine/threonine-protein kinase tricorner OS=Drosophila pseudoobscura pseudoobscura GN=trc PE=3 SV=1 PF07714//PF04096//PF00433//PF06293//PF00069//PF04998 Protein tyrosine kinase//Nucleoporin autopeptidase//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//RNA polymerase Rpb1, domain 5 GO:0006206//GO:0006351//GO:0016310//GO:0006144//GO:0006810//GO:0006468//GO:0009069 pyrimidine nucleobase metabolic process//transcription, DNA-templated//phosphorylation//purine nucleobase metabolic process//transport//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004672//GO:0003677//GO:0004674//GO:0003899//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//DNA binding//protein serine/threonine kinase activity//DNA-directed RNA polymerase activity//ATP binding GO:0016020//GO:0005643//GO:0005730 membrane//nuclear pore//nucleolus KOG0605 NDR and related serine/threonine kinases Cluster-8309.27470 BF_2 118.79 3.04 1922 236468408 NP_001153625.1 896 1.6e-93 spaetzle 3 [Tribolium castaneum] 817194790 XM_012417488.1 155 5.92868e-73 PREDICTED: Orussus abietinus uncharacterized LOC105695690 (LOC105695690), mRNA -- -- -- -- -- -- -- -- PF02035 Coagulin GO:0042381 hemolymph coagulation -- -- GO:0005576 extracellular region -- -- Cluster-8309.27473 BF_2 39.95 0.35 5127 91089951 XP_973444.1 1186 1.0e-126 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013551|gb|EFA09999.1| hypothetical protein TcasGA2_TC012169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 440 1.3e-41 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF01061//PF13304//PF00005 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter -- -- GO:0016887//GO:0005524//GO:0017111 ATPase activity//ATP binding//nucleoside-triphosphatase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.27474 BF_2 65.37 1.18 2607 270003794 EFA00242.1 795 1.1e-81 hypothetical protein TcasGA2_TC003070 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01105//PF04992//PF06156 emp24/gp25L/p24 family/GOLD//RNA polymerase Rpb1, domain 6//Protein of unknown function (DUF972) GO:0006351//GO:0006810//GO:0006144//GO:0006260//GO:0006206 transcription, DNA-templated//transport//purine nucleobase metabolic process//DNA replication//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0016021//GO:0005730 integral component of membrane//nucleolus -- -- Cluster-8309.27475 BF_2 288.00 7.39 1917 91084359 XP_973264.1 1545 8.7e-169 PREDICTED: facilitated trehalose transporter Tret1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY3 534 6.1e-53 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF02200 Sugar (and other) transporter//Major Facilitator Superfamily//STE like transcription factor GO:0055085//GO:0006355 transmembrane transport//regulation of transcription, DNA-templated GO:0022857//GO:0003700 transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0016021//GO:0005667 nucleus//integral component of membrane//transcription factor complex KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.27477 BF_2 84.34 2.09 1979 642922261 XP_008193083.1 175 6.6e-10 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27478 BF_2 121.62 2.68 2185 642915291 XP_008190557.1 1450 1.0e-157 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 678 1.4e-69 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.27479 BF_2 190.05 5.78 1663 478255105 ENN75335.1 993 7.7e-105 hypothetical protein YQE_08111, partial [Dendroctonus ponderosae]>gi|546680135|gb|ERL90476.1| hypothetical protein D910_07825 [Dendroctonus ponderosae] 766923225 XM_011507925.1 101 5.33672e-43 PREDICTED: Ceratosolen solmsi marchali uracil phosphoribosyltransferase homolog (LOC105368798), transcript variant X2, mRNA K00761 upp, UPRT uracil phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00761 Q5ZIJ8 706 6.1e-73 Uracil phosphoribosyltransferase homolog OS=Gallus gallus GN=UPRT PE=2 SV=1 PF00156 Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process -- -- -- -- KOG1017 Predicted uracil phosphoribosyltransferase Cluster-8309.2748 BF_2 2.00 0.48 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27480 BF_2 317.33 2.71 5189 91084319 XP_972276.1 1874 1.7e-206 PREDICTED: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum]>gi|270008807|gb|EFA05255.1| hypothetical protein TcasGA2_TC015407 [Tribolium castaneum] -- -- -- -- -- K03848 ALG6 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03848 Q802T2 1115 7.1e-120 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Gallus gallus GN=ALG6 PE=2 SV=1 PF00288//PF03155//PF04055 GHMP kinases N terminal domain//ALG6, ALG8 glycosyltransferase family//Radical SAM superfamily -- -- GO:0016758//GO:0005524//GO:0003824//GO:0051536 transferase activity, transferring hexosyl groups//ATP binding//catalytic activity//iron-sulfur cluster binding GO:0005789 endoplasmic reticulum membrane KOG2575 Glucosyltransferase - Alg6p Cluster-8309.27481 BF_2 433.13 6.59 3038 189238741 XP_972079.2 2951 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927110|ref|XP_008195141.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927112|ref|XP_008195142.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927115|ref|XP_008195143.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum] 699256288 XM_009863644.1 39 2.87412e-08 PREDICTED: Ciona intestinalis ubiquitin carboxyl-terminal hydrolase 20-like (LOC100184024), mRNA K11848 USP20_33 ubiquitin carboxyl-terminal hydrolase 20/33 http://www.genome.jp/dbget-bin/www_bget?ko:K11848 A0JM59 1233 8.6e-134 Ubiquitin carboxyl-terminal hydrolase 20 OS=Xenopus tropicalis GN=usp20 PE=2 SV=1 PF00443//PF17001//PF06337//PF02148 Ubiquitin carboxyl-terminal hydrolase//Type III secretion basal body protein I, YscI, HrpB, PscI//DUSP domain//Zn-finger in ubiquitin-hydrolases and other protein GO:0009306//GO:0016579//GO:0006508 protein secretion//protein deubiquitination//proteolysis GO:0036459//GO:0008270//GO:0004843 ubiquitinyl hydrolase activity//zinc ion binding//ubiquitin-specific protease activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.27482 BF_2 20.96 0.74 1467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27483 BF_2 46.00 1.32 1747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27487 BF_2 157.83 1.09 6354 642912779 XP_008201247.1 4214 0.0e+00 PREDICTED: chaoptin isoform X1 [Tribolium castaneum] 759065584 XM_011343927.1 47 2.1592e-12 PREDICTED: Cerapachys biroi homeobox protein Hox-B1a-like (LOC105282160), mRNA -- -- -- -- P12024 2995 0.0e+00 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF13855//PF00046 Leucine Rich Repeat//Leucine rich repeat//Homeobox domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.27488 BF_2 88.95 2.34 1878 270002810 EEZ99257.1 859 3.0e-89 labial [Tribolium castaneum] 641679658 XM_008190431.1 60 3.74042e-20 PREDICTED: Acyrthosiphon pisum homeobox protein Hox-A1-like (LOC103310939), mRNA K09301 HOX_1 homeobox protein HoxA/B/D1 http://www.genome.jp/dbget-bin/www_bget?ko:K09301 Q28IU6 252 3.0e-20 Homeobox protein Hox-D1 OS=Xenopus tropicalis GN=hoxd1 PE=2 SV=1 PF00046//PF02325 Homeobox domain//YGGT family -- -- GO:0003677 DNA binding GO:0016020 membrane KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.27490 BF_2 86.00 1.52 2654 123227460 CAM27169.1 868 3.9e-90 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] 741950160 XM_010812049.1 36 1.16696e-06 PREDICTED: Bos taurus zinc finger and SCAN domain-containing protein 5B-like (LOC790324), partial mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8N8J6 853 8.7e-90 Zinc finger protein 615 OS=Homo sapiens GN=ZNF615 PE=2 SV=2 PF07776//PF13912//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.27491 BF_2 130.00 2.22 2735 642916469 XP_008191039.1 2873 0.0e+00 PREDICTED: anaphase-promoting complex subunit 2 [Tribolium castaneum]>gi|270003625|gb|EFA00073.1| hypothetical protein TcasGA2_TC002887 [Tribolium castaneum] -- -- -- -- -- K03349 APC2 anaphase-promoting complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03349 Q9UJX6 1367 2.2e-149 Anaphase-promoting complex subunit 2 OS=Homo sapiens GN=ANAPC2 PE=1 SV=1 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2165 Anaphase-promoting complex (APC), subunit 2 Cluster-8309.27492 BF_2 31.29 0.35 4049 642914581 XP_008190273.1 930 3.8e-97 PREDICTED: uncharacterized protein LOC660922 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02568 Thiamine biosynthesis protein (ThiI) GO:0008033 tRNA processing GO:0004810 tRNA adenylyltransferase activity -- -- -- -- Cluster-8309.27493 BF_2 82.00 3.80 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646 F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27494 BF_2 164.48 1.93 3847 270006887 EFA03335.1 1380 2.4e-149 hypothetical protein TcasGA2_TC013312 [Tribolium castaneum] -- -- -- -- -- K00968 PCYT1 choline-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00968 Q9Y5K3 807 2.7e-84 Choline-phosphate cytidylyltransferase B OS=Homo sapiens GN=PCYT1B PE=1 SV=1 PF01467//PF12326//PF01733//PF00600 Cytidylyltransferase-like//N-glycosylation protein//Nucleoside transporter//Influenza non-structural protein (NS1) GO:0015858//GO:0006810//GO:0034599//GO:0009058 nucleoside transport//transport//cellular response to oxidative stress//biosynthetic process GO:0003723//GO:0003824//GO:0005337 RNA binding//catalytic activity//nucleoside transmembrane transporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.27495 BF_2 3.50 0.57 543 91087023 XP_974255.1 468 1.9e-44 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q17QM4 295 9.0e-26 Ethanolaminephosphotransferase 1 OS=Bos taurus GN=EPT1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.27496 BF_2 44.50 0.95 2252 332372732 AEE61508.1 1086 1.7e-115 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 735 3.6e-76 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191//PF08294//PF00802 Annexin//TIM21//Pneumovirus attachment glycoprotein G GO:0030150 protein import into mitochondrial matrix GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding GO:0055036//GO:0005744 virion membrane//mitochondrial inner membrane presequence translocase complex KOG0819 Annexin Cluster-8309.27497 BF_2 7.92 0.35 1230 91078976 XP_974454.1 397 7.4e-36 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27499 BF_2 14.00 1.98 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2750 BF_2 20.00 0.65 1572 642914257 XP_008201609.1 2342 2.7e-261 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UV71 790 1.0e-82 Transmembrane and TPR repeat-containing protein 1 OS=Mus musculus GN=Tmtc1 PE=2 SV=2 PF13414//PF13174//PF13176//PF00515//PF13374//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1124 FOG: TPR repeat Cluster-8309.27501 BF_2 620.17 7.40 3791 91082211 XP_972371.1 1201 1.3e-128 PREDICTED: caspase-8 [Tribolium castaneum]>gi|270008200|gb|EFA04648.1| death related ced-3/Nedd2-like protein [Tribolium castaneum] -- -- -- -- -- K15275 SLC35B1 solute carrier family 35 (UDP-galactose transporter), member B1 http://www.genome.jp/dbget-bin/www_bget?ko:K15275 Q9VDD7 776 1.1e-80 Solute carrier family 35 member B1 homolog OS=Drosophila melanogaster GN=meigo PE=2 SV=1 PF08449//PF00656//PF00892 UAA transporter family//Caspase domain//EamA-like transporter family GO:0055085//GO:0006508 transmembrane transport//proteolysis GO:0004197 cysteine-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1581 UDP-galactose transporter related protein Cluster-8309.27502 BF_2 405.00 12.33 1661 264667473 ACY71322.1 543 1.2e-52 non-histone chromosome protein 2 [Chrysomela tremula] 689542333 LL999135.1 61 9.17526e-21 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_contig0000068 K12845 SNU13, NHP2L U4/U6 small nuclear ribonucleoprotein SNU13 http://www.genome.jp/dbget-bin/www_bget?ko:K12845 Q5XH16 475 3.7e-46 NHP2-like protein 1 OS=Xenopus laevis GN=nhp2l1 PE=2 SV=1 PF07180 Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- -- -- KOG3387 60S ribosomal protein 15.5kD/SNU13, NHP2/L7A family (includes ribonuclease P subunit p38), involved in splicing Cluster-8309.27506 BF_2 18.09 0.46 1928 642934605 XP_971300.2 424 8.6e-39 PREDICTED: CD63 antigen [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q9XSK2 188 8.2e-13 CD63 antigen OS=Bos taurus GN=CD63 PE=2 SV=4 PF00115//PF03390//PF05149//PF00335 Cytochrome C and Quinol oxidase polypeptide I//2-hydroxycarboxylate transporter family//Paraflagellar rod protein//Tetraspanin family GO:0009060//GO:0006123//GO:0015992//GO:0055114//GO:0006118//GO:0015711 aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen//proton transport//oxidation-reduction process//obsolete electron transport//organic anion transport GO:0005516//GO:0005506//GO:0004129//GO:0020037//GO:0008514//GO:0009055 calmodulin binding//iron ion binding//cytochrome-c oxidase activity//heme binding//organic anion transmembrane transporter activity//electron carrier activity GO:0045277//GO:0031514//GO:0016021 respiratory chain complex IV//motile cilium//integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.27507 BF_2 64.00 1.03 2877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00672//PF08783 HAMP domain//DWNN domain GO:0007165 signal transduction GO:0004871//GO:0008270 signal transducer activity//zinc ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.27509 BF_2 651.67 12.62 2447 91080725 XP_975392.1 2452 7.5e-274 PREDICTED: arginine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270005463|gb|EFA01911.1| hypothetical protein TcasGA2_TC007521 [Tribolium castaneum] 306980173 CP002198.1 65 8.13369e-23 Cyanothece sp. PCC 7822, complete genome K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 Q5ZM11 1964 1.2e-218 Arginine--tRNA ligase, cytoplasmic OS=Gallus gallus GN=RARS PE=2 SV=1 PF05746//PF00133//PF09334//PF03485//PF00750//PF07062 DALR anticodon binding domain//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Arginyl tRNA synthetase N terminal domain//tRNA synthetases class I (R)//Clc-like GO:0006525//GO:0006560//GO:0006420//GO:0006418 arginine metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0005524//GO:0004814//GO:0000166//GO:0004812 ATP binding//arginine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG4426 Arginyl-tRNA synthetase Cluster-8309.2751 BF_2 12.00 0.81 908 642914257 XP_008201609.1 192 3.2e-12 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27513 BF_2 838.78 9.13 4130 91086685 XP_969056.1 2107 1.3e-233 PREDICTED: ubiquitin carboxyl-terminal hydrolase 14 [Tribolium castaneum]>gi|270009745|gb|EFA06193.1| hypothetical protein TcasGA2_TC009042 [Tribolium castaneum] 871234385 XM_013082848.1 61 2.30945e-20 PREDICTED: Aplysia californica ubiquitin carboxyl-terminal hydrolase 14-like (LOC101847343), mRNA K11843 USP14, UBP6 ubiquitin carboxyl-terminal hydrolase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11843 Q9JMA1 1512 5.2e-166 Ubiquitin carboxyl-terminal hydrolase 14 OS=Mus musculus GN=Usp14 PE=1 SV=3 PF00240//PF15499//PF00443 Ubiquitin family//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006511//GO:0006508 protein deubiquitination//ubiquitin-dependent protein catabolic process//proteolysis GO:0008234//GO:0004221//GO:0005515//GO:0036459//GO:0032183//GO:0070140 cysteine-type peptidase activity//obsolete ubiquitin thiolesterase activity//protein binding//ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity -- -- KOG1872 Ubiquitin-specific protease Cluster-8309.27514 BF_2 28.01 0.66 2073 189235221 XP_967494.2 169 3.4e-09 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27516 BF_2 10.39 0.60 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27518 BF_2 1170.21 7.71 6634 642919747 XP_008192048.1 4344 0.0e+00 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 1423 1.7e-155 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3321 Mitochondrial ribosomal protein S10 Cluster-8309.2752 BF_2 32.11 1.75 1053 642914257 XP_008201609.1 655 7.6e-66 PREDICTED: transmembrane and TPR repeat-containing protein 1-like [Tribolium castaneum]>gi|270001551|gb|EEZ97998.1| hypothetical protein TcasGA2_TC000396 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BRH0 351 5.6e-32 Transmembrane and TPR repeat-containing protein 3 OS=Mus musculus GN=Tmtc3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27523 BF_2 18.00 2.86 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27526 BF_2 17.43 0.69 1348 270015220 EFA11668.1 1513 3.2e-165 hypothetical protein TcasGA2_TC008532 [Tribolium castaneum] -- -- -- -- -- K01755 argH, ASL argininosuccinate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01755 P51464 1179 7.0e-128 Argininosuccinate lyase OS=Lithobates catesbeiana GN=ASL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1316 Argininosuccinate lyase Cluster-8309.27528 BF_2 370.09 8.87 2033 642917706 XP_008191338.1 1628 2.2e-178 PREDICTED: WD repeat-containing protein 43 [Tribolium castaneum] -- -- -- -- -- K14546 UTP5, WDR43 U3 small nucleolar RNA-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K14546 Q15061 707 5.7e-73 WD repeat-containing protein 43 OS=Homo sapiens GN=WDR43 PE=1 SV=3 PF09384//PF00400 UTP15 C terminal//WD domain, G-beta repeat GO:0006364 rRNA processing GO:0005515 protein binding GO:0005730 nucleolus KOG4547 WD40 repeat-containing protein Cluster-8309.27532 BF_2 40.00 3.85 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27534 BF_2 338.00 4.25 3617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02786 Carbamoyl-phosphate synthase L chain, ATP binding domain -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.27535 BF_2 120.62 1.12 4788 642915090 XP_008190408.1 1130 2.9e-120 PREDICTED: probable uridine-cytidine kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 910 3.9e-96 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF03810//PF02224//PF00437//PF07690//PF00083//PF09547//PF06414//PF01121//PF00485 Importin-beta N-terminal domain//Cytidylate kinase//Type II/IV secretion system protein//Major Facilitator Superfamily//Sugar (and other) transporter//Stage IV sporulation protein A (spore_IV_A)//Zeta toxin//Dephospho-CoA kinase//Phosphoribulokinase / Uridine kinase family GO:0006206//GO:0043934//GO:0008152//GO:0015937//GO:0015940//GO:0055085//GO:0006886//GO:0006139//GO:0006810 pyrimidine nucleobase metabolic process//sporulation//metabolic process//coenzyme A biosynthetic process//pantothenate biosynthetic process//transmembrane transport//intracellular protein transport//nucleobase-containing compound metabolic process//transport GO:0004140//GO:0022857//GO:0008536//GO:0016887//GO:0004127//GO:0016301//GO:0005524 dephospho-CoA kinase activity//transmembrane transporter activity//Ran GTPase binding//ATPase activity//cytidylate kinase activity//kinase activity//ATP binding GO:0016021 integral component of membrane KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.27536 BF_2 21.69 1.03 1169 642915092 XP_969315.3 409 2.8e-37 PREDICTED: probable uridine-cytidine kinase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 369 5.1e-34 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF00485 Phosphoribulokinase / Uridine kinase family GO:0008152 metabolic process GO:0016301//GO:0005524 kinase activity//ATP binding -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.27537 BF_2 253.73 3.21 3590 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.27539 BF_2 766.00 15.81 2314 86515348 NP_001034501.1 1526 1.7e-166 extradenticle [Tribolium castaneum]>gi|38490515|emb|CAD57734.1| extradenticle [Tribolium castaneum] 332672665 HM157269.1 87 4.52816e-35 Sepia officinalis pre-B-cell leukemia transcription factor 1 (PBX1) mRNA, partial cds K09355 PBX1 pre-B-cell leukemia transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09355 P40427 1323 2.4e-144 Homeobox protein extradenticle OS=Drosophila melanogaster GN=exd PE=1 SV=1 PF04218//PF03792//PF01381//PF12844//PF05920//PF00046//PF00443//PF13443 CENP-B N-terminal DNA-binding domain//PBC domain//Helix-turn-helix//Helix-turn-helix domain//Homeobox KN domain//Homeobox domain//Ubiquitin carboxyl-terminal hydrolase//Cro/C1-type HTH DNA-binding domain GO:0006355//GO:0016579 regulation of transcription, DNA-templated//protein deubiquitination GO:0043565//GO:0003700//GO:0003677//GO:0036459 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//ubiquitinyl hydrolase activity GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0774 Transcription factor PBX and related HOX domain proteins Cluster-8309.27540 BF_2 43.57 0.40 4857 270005503 EFA01951.1 635 7.4e-63 hypothetical protein TcasGA2_TC007566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09197//PF04272 Rap1, DNA-binding//Phospholamban GO:0006810//GO:0006816 transport//calcium ion transport GO:0042030//GO:0003677//GO:0005246 ATPase inhibitor activity//DNA binding//calcium channel regulator activity GO:0016020 membrane -- -- Cluster-8309.27541 BF_2 323.30 3.34 4337 189237077 XP_968819.2 4221 0.0e+00 PREDICTED: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase [Tribolium castaneum]>gi|642922088|ref|XP_008193012.1| PREDICTED: bifunctional heparan sulfate N-deacetylase/N-sulfotransferase [Tribolium castaneum]>gi|270007422|gb|EFA03870.1| hypothetical protein TcasGA2_TC013993 [Tribolium castaneum] -- -- -- -- -- K02577 NDST2 heparan sulfate N-deacetylase/N-sulfotransferase NDST2 http://www.genome.jp/dbget-bin/www_bget?ko:K02577 Q9V3L1 3430 0.0e+00 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase OS=Drosophila melanogaster GN=sfl PE=1 SV=1 PF12062//PF00685 heparan sulfate-N-deacetylase//Sulfotransferase domain -- -- GO:0008146//GO:0016787//GO:0015016 sulfotransferase activity//hydrolase activity//[heparan sulfate]-glucosamine N-sulfotransferase activity -- -- KOG3703 Heparan sulfate N-deacetylase/N-sulfotransferase Cluster-8309.27542 BF_2 254.45 3.29 3527 642922624 XP_008193254.1 3543 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27543 BF_2 35.00 3.09 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27544 BF_2 64.75 2.61 1325 642913536 XP_008201054.1 326 1.4e-27 PREDICTED: uncharacterized protein C1orf131 [Tribolium castaneum]>gi|270002041|gb|EEZ98488.1| hypothetical protein TcasGA2_TC000985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15064 Cation channel sperm-associated protein subunit gamma -- -- -- -- GO:0036128//GO:0097228 CatSper complex//sperm principal piece -- -- Cluster-8309.27545 BF_2 58.25 2.18 1405 642913536 XP_008201054.1 326 1.4e-27 PREDICTED: uncharacterized protein C1orf131 [Tribolium castaneum]>gi|270002041|gb|EEZ98488.1| hypothetical protein TcasGA2_TC000985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15064 Cation channel sperm-associated protein subunit gamma -- -- -- -- GO:0097228//GO:0036128 sperm principal piece//CatSper complex -- -- Cluster-8309.27550 BF_2 9.00 0.38 1280 795538217 XP_011716060.1 1306 3.0e-141 PREDICTED: myosin-11 [Macaca nemestrina] 767987245 XM_011522502.1 871 0 PREDICTED: Homo sapiens myosin, heavy chain 11, smooth muscle (MYH11), transcript variant X1, mRNA >gnl|BL_ORD_ID|28067655 PREDICTED: Homo sapiens myosin, heavy chain 11, smooth muscle (MYH11), transcript variant X1, mRNA K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 P35749 1306 1.2e-142 Myosin-11 OS=Homo sapiens GN=MYH11 PE=1 SV=3 PF01601//PF06009//PF04111//PF13851//PF01576//PF04871//PF09177//PF06160//PF00769//PF00038 Coronavirus S2 glycoprotein//Laminin Domain II//Autophagy protein Apg6//Growth-arrest specific micro-tubule binding//Myosin tail//Uso1 / p115 like vesicle tethering protein, C terminal region//Syntaxin 6, N-terminal//Septation ring formation regulator, EzrA//Ezrin/radixin/moesin family//Intermediate filament protein GO:0046813//GO:0007155//GO:0061025//GO:0000921//GO:0048870//GO:0048193//GO:0015031//GO:0006914//GO:0006886 receptor-mediated virion attachment to host cell//cell adhesion//membrane fusion//septin ring assembly//cell motility//Golgi vesicle transport//protein transport//autophagy//intracellular protein transport GO:0003774//GO:0008092//GO:0008565//GO:0005198 motor activity//cytoskeletal protein binding//protein transporter activity//structural molecule activity GO:0016020//GO:0019031//GO:0005737//GO:0005882//GO:0005940//GO:0016021//GO:0019898//GO:0016459//GO:0031514 membrane//viral envelope//cytoplasm//intermediate filament//septin ring//integral component of membrane//extrinsic component of membrane//myosin complex//motile cilium KOG0161 Myosin class II heavy chain Cluster-8309.27551 BF_2 100.72 12.73 618 332375664 AEE62973.1 288 1.6e-23 unknown [Dendroctonus ponderosae]>gi|478254613|gb|ENN74856.1| hypothetical protein YQE_08626, partial [Dendroctonus ponderosae]>gi|546673364|gb|ERL84987.1| hypothetical protein D910_02410 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZC48 229 4.6e-18 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-8309.27552 BF_2 163.79 4.40 1846 91089167 XP_974028.1 1509 1.3e-164 PREDICTED: DNA-directed RNA polymerase III subunit RPC5 [Tribolium castaneum]>gi|270011487|gb|EFA07935.1| hypothetical protein TcasGA2_TC005516 [Tribolium castaneum] -- -- -- -- -- K14721 RPC5, POLR3E DNA-directed RNA polymerase III subunit RPC5 http://www.genome.jp/dbget-bin/www_bget?ko:K14721 Q9NVU0 686 1.4e-70 DNA-directed RNA polymerase III subunit RPC5 OS=Homo sapiens GN=POLR3E PE=1 SV=1 PF05132//PF04801 RNA polymerase III RPC4//Sin-like protein conserved region GO:0006206//GO:0006351//GO:0006383//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005666//GO:0005730//GO:0005634 DNA-directed RNA polymerase III complex//nucleolus//nucleus KOG2354 RNA Polymerase C (III) 37 kDa subunit Cluster-8309.27553 BF_2 165.67 7.74 1182 91079136 XP_975456.1 331 3.2e-28 PREDICTED: uncharacterized protein LOC664352 [Tribolium castaneum]>gi|270003627|gb|EFA00075.1| hypothetical protein TcasGA2_TC002890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27556 BF_2 584.48 15.20 1896 642919850 XP_008192095.1 1809 2.1e-199 PREDICTED: protein tumorous imaginal discs, mitochondrial isoform X1 [Tribolium castaneum] 642919851 XM_968364.3 179 2.66321e-86 PREDICTED: Tribolium castaneum protein tumorous imaginal discs, mitochondrial (LOC662253), transcript variant X2, mRNA K09504 DNAJA3 DnaJ homolog subfamily A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09504 Q24331 1402 1.4e-153 Protein tumorous imaginal discs, mitochondrial OS=Drosophila virilis GN=l(2)tid PE=2 SV=1 PF00684 DnaJ central domain -- -- GO:0051082//GO:0031072 unfolded protein binding//heat shock protein binding -- -- KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.27560 BF_2 3.00 0.67 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27562 BF_2 4.47 0.34 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27564 BF_2 378.45 15.79 1290 270011668 EFA08116.1 382 4.2e-34 hypothetical protein TcasGA2_TC005720 [Tribolium castaneum] -- -- -- -- -- K14325 RNPS1 RNA-binding protein with serine-rich domain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14325 Q3KPW1 288 1.4e-24 RNA-binding protein with serine-rich domain 1-B OS=Xenopus laevis GN=rnps1-b PE=2 SV=1 PF09726//PF00076//PF16367 Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.27565 BF_2 66.71 2.82 1278 270011668 EFA08116.1 382 4.2e-34 hypothetical protein TcasGA2_TC005720 [Tribolium castaneum] -- -- -- -- -- K14325 RNPS1 RNA-binding protein with serine-rich domain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14325 Q3KPW1 288 1.4e-24 RNA-binding protein with serine-rich domain 1-B OS=Xenopus laevis GN=rnps1-b PE=2 SV=1 PF10486//PF16367//PF00076//PF09726 Phosphoinositide 3-kinase gamma adapter protein p101 subunit//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein -- -- GO:0003676//GO:0046935 nucleic acid binding//1-phosphatidylinositol-3-kinase regulator activity GO:0005944//GO:0016021 phosphatidylinositol 3-kinase complex, class IB//integral component of membrane KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.27566 BF_2 16.28 0.61 1402 270011668 EFA08116.1 382 4.6e-34 hypothetical protein TcasGA2_TC005720 [Tribolium castaneum] -- -- -- -- -- K14325 RNPS1 RNA-binding protein with serine-rich domain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14325 Q3KPW1 288 1.5e-24 RNA-binding protein with serine-rich domain 1-B OS=Xenopus laevis GN=rnps1-b PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4209 Splicing factor RNPS1, SR protein superfamily Cluster-8309.27567 BF_2 65.34 0.66 4424 642937862 XP_008200329.1 2459 2.1e-274 PREDICTED: PHD finger protein 19 [Tribolium castaneum]>gi|270000755|gb|EEZ97202.1| hypothetical protein TcasGA2_TC004391 [Tribolium castaneum] -- -- -- -- -- K11485 MTF2, PCL2 polycomb-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11485 Q9Y483 739 2.4e-76 Metal-response element-binding transcription factor 2 OS=Homo sapiens GN=MTF2 PE=1 SV=2 PF00130//PF00628//PF05191 Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//Adenylate kinase, active site lid GO:0006144//GO:0035556//GO:0046034 purine nucleobase metabolic process//intracellular signal transduction//ATP metabolic process GO:0004017//GO:0005515 adenylate kinase activity//protein binding -- -- -- -- Cluster-8309.2757 BF_2 4.00 0.76 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27571 BF_2 438.61 21.87 1126 189233795 XP_973362.2 594 9.7e-59 PREDICTED: FUN14 domain-containing protein 1-like isoform X1 [Tribolium castaneum]>gi|642910988|ref|XP_008193497.1| PREDICTED: FUN14 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17986 FUNDC1 FUN14 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17986 Q4RY26 198 3.3e-14 FUN14 domain-containing protein 1 OS=Tetraodon nigroviridis GN=fundc1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4099 Predicted membrane protein Cluster-8309.27573 BF_2 283.81 2.18 5736 91084319 XP_972276.1 1874 1.9e-206 PREDICTED: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum]>gi|270008807|gb|EFA05255.1| hypothetical protein TcasGA2_TC015407 [Tribolium castaneum] -- -- -- -- -- K03848 ALG6 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03848 Q802T2 1115 7.8e-120 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Gallus gallus GN=ALG6 PE=2 SV=1 PF00288//PF03155//PF05480//PF04055 GHMP kinases N terminal domain//ALG6, ALG8 glycosyltransferase family//Staphylococcus haemolytic protein//Radical SAM superfamily GO:0009405 pathogenesis GO:0005524//GO:0051536//GO:0016758//GO:0003824 ATP binding//iron-sulfur cluster binding//transferase activity, transferring hexosyl groups//catalytic activity GO:0005789 endoplasmic reticulum membrane KOG2575 Glucosyltransferase - Alg6p Cluster-8309.27574 BF_2 55.09 1.54 1780 189240485 XP_967921.2 1610 2.4e-176 PREDICTED: poly(A)-specific ribonuclease PARN [Tribolium castaneum]>gi|270011407|gb|EFA07855.1| hypothetical protein TcasGA2_TC005425 [Tribolium castaneum] -- -- -- -- -- K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 P69341 1069 5.2e-115 Poly(A)-specific ribonuclease PARN OS=Bos taurus GN=PARN PE=1 SV=2 PF14993//PF04857//PF08675//PF05669//PF01424 Neuropeptide S precursor protein//CAF1 family ribonuclease//RNA binding domain//SOH1//R3H domain GO:0051252//GO:0006355//GO:0007218//GO:0006402 regulation of RNA metabolic process//regulation of transcription, DNA-templated//neuropeptide signaling pathway//mRNA catabolic process GO:0046872//GO:0003676//GO:0004535//GO:0003723//GO:0001104 metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity//RNA binding//RNA polymerase II transcription cofactor activity GO:0005737//GO:0005576//GO:0044424//GO:0016592//GO:0005634 cytoplasm//extracellular region//intracellular part//mediator complex//nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.27582 BF_2 677.05 25.47 1399 91095059 XP_972457.1 1421 1.5e-154 PREDICTED: uroporphyrinogen decarboxylase [Tribolium castaneum] -- -- -- -- -- K01599 hemE, UROD uroporphyrinogen decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01599 Q9V595 1159 1.5e-125 Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 PF01208 Uroporphyrinogen decarboxylase (URO-D) GO:0015994//GO:0006779 chlorophyll metabolic process//porphyrin-containing compound biosynthetic process GO:0004853 uroporphyrinogen decarboxylase activity -- -- KOG2872 Uroporphyrinogen decarboxylase Cluster-8309.27589 BF_2 81.56 2.69 1557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27590 BF_2 20.00 0.63 1614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27591 BF_2 539.39 37.74 885 642921732 XP_008199304.1 654 8.4e-66 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 488 6.1e-48 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.27592 BF_2 47.65 4.07 777 91083773 XP_972220.1 272 1.5e-21 PREDICTED: uncharacterized protein LOC660933 [Tribolium castaneum]>gi|270006783|gb|EFA03231.1| hypothetical protein TcasGA2_TC013160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27593 BF_2 294.00 25.90 762 91086169 XP_970456.1 741 5.9e-76 PREDICTED: nucleolysin TIAR [Tribolium castaneum]>gi|270010230|gb|EFA06678.1| hypothetical protein TcasGA2_TC009608 [Tribolium castaneum] 642927790 XM_965363.2 109 8.52536e-48 PREDICTED: Tribolium castaneum nucleolysin TIAR (LOC659024), mRNA K13201 TIA1, TIAL1 nucleolysin TIA-1/TIAR http://www.genome.jp/dbget-bin/www_bget?ko:K13201 Q01085 451 1.0e-43 Nucleolysin TIAR OS=Homo sapiens GN=TIAL1 PE=1 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) Cluster-8309.27595 BF_2 8.00 2.75 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27596 BF_2 492.18 2.88 7438 189241728 XP_966529.2 2295 3.7e-255 PREDICTED: polycomb protein Scm [Tribolium castaneum] 817209209 XM_012425227.1 101 2.42459e-42 PREDICTED: Orussus abietinus polycomb protein Scm-like (LOC105699853), transcript variant X3, mRNA K11461 SCMH1 polycomb protein SCMH1 http://www.genome.jp/dbget-bin/www_bget?ko:K11461 Q9VHA0 1384 6.5e-151 Polycomb protein Scm OS=Drosophila melanogaster GN=Scm PE=1 SV=2 PF07647//PF00536//PF02069//PF02820//PF03145//PF06467 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Prokaryotic metallothionein//mbt repeat//Seven in absentia protein family//MYM-type Zinc finger with FCS sequence motif GO:0006511//GO:0006355//GO:0007275 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated//multicellular organismal development GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.27597 BF_2 7.00 1.18 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27599 BF_2 21.54 0.32 3110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27600 BF_2 42.67 0.42 4555 642934618 XP_008197739.1 2862 0.0e+00 PREDICTED: zinc finger protein 62-like [Tribolium castaneum]>gi|270013744|gb|EFA10192.1| hypothetical protein TcasGA2_TC012384 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05481 443 5.2e-42 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096//PF07776//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.27602 BF_2 279.79 3.05 4129 270001519 EEZ97966.1 2063 1.6e-228 hypothetical protein TcasGA2_TC000358 [Tribolium castaneum] 462381540 APGK01021978.1 59 2.98674e-19 Dendroctonus ponderosae Seq01021988, whole genome shotgun sequence K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 571 6.8e-57 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF07926//PF00005//PF08702//PF13851//PF06810//PF06160//PF10473//PF11365//PF00769//PF05557//PF06220//PF02050//PF04111//PF09730//PF13443//PF01576 TPR/MLP1/MLP2-like protein//ABC transporter//Fibrinogen alpha/beta chain family//Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Mitotic checkpoint protein//U1 zinc finger//Flagellar FliJ protein//Autophagy protein Apg6//Microtubule-associated protein Bicaudal-D//Cro/C1-type HTH DNA-binding domain//Myosin tail GO:0030168//GO:0006935//GO:0048870//GO:0000921//GO:0071973//GO:0006606//GO:0010506//GO:0007094//GO:0007165//GO:0006810//GO:0006914//GO:0051258 platelet activation//chemotaxis//cell motility//septin ring assembly//bacterial-type flagellum-dependent cell motility//protein import into nucleus//regulation of autophagy//mitotic spindle assembly checkpoint//signal transduction//transport//autophagy//protein polymerization GO:0003774//GO:0030674//GO:0008092//GO:0016887//GO:0005102//GO:0005524//GO:0045502//GO:0008134//GO:0042803//GO:0008270//GO:0043565//GO:0005198 motor activity//protein binding, bridging//cytoskeletal protein binding//ATPase activity//receptor binding//ATP binding//dynein binding//transcription factor binding//protein homodimerization activity//zinc ion binding//sequence-specific DNA binding//structural molecule activity GO:0030286//GO:0005667//GO:0009288//GO:0005577//GO:0005615//GO:0019898//GO:0005794//GO:0016020//GO:0005737//GO:0016459//GO:0031514//GO:0016021//GO:0005940 dynein complex//transcription factor complex//bacterial-type flagellum//fibrinogen complex//extracellular space//extrinsic component of membrane//Golgi apparatus//membrane//cytoplasm//myosin complex//motile cilium//integral component of membrane//septin ring -- -- Cluster-8309.27606 BF_2 118.20 2.36 2386 483524390 EOB08387.1 722 3.0e-73 Aldose reductase, partial [Anas platyrhynchos] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q6AZW2 504 2.3e-49 Alcohol dehydrogenase [NADP(+)] A OS=Danio rerio GN=akr1a1a PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.27609 BF_2 683.87 14.64 2241 546681042 ERL91207.1 2449 1.5e-273 hypothetical protein D910_08545 [Dendroctonus ponderosae] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10714 1662 1.1e-183 Angiotensin-converting enzyme OS=Drosophila melanogaster GN=Ance PE=1 SV=3 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.27610 BF_2 1159.21 12.02 4323 91076900 XP_975025.1 1414 3.1e-153 PREDICTED: Y+L amino acid transporter 2 [Tribolium castaneum] 817087970 XM_012411364.1 68 3.10625e-24 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q8BGK6 858 3.7e-90 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF00324//PF01424//PF01990//PF13520 Amino acid permease//R3H domain//ATP synthase (F/14-kDa) subunit//Amino acid permease GO:0034220//GO:0006810//GO:0055085//GO:0006865//GO:0003333 ion transmembrane transport//transport//transmembrane transport//amino acid transport//amino acid transmembrane transport GO:0015171//GO:0003676 amino acid transmembrane transporter activity//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.27611 BF_2 1301.42 8.97 6355 189237853 XP_974947.2 2561 4.5e-286 PREDICTED: protein abrupt isoform X1 [Tribolium castaneum]>gi|642924667|ref|XP_008194388.1| PREDICTED: protein abrupt isoform X1 [Tribolium castaneum]>gi|642924669|ref|XP_008194389.1| PREDICTED: protein abrupt isoform X1 [Tribolium castaneum]>gi|642924671|ref|XP_008194390.1| PREDICTED: protein abrupt isoform X1 [Tribolium castaneum] 642924672 XM_969854.3 737 0 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X4, mRNA -- -- -- -- Q24174 724 1.9e-74 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF00651//PF02892//PF00096 BTB/POZ domain//BED zinc finger//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0003677 metal ion binding//protein binding//DNA binding -- -- -- -- Cluster-8309.27612 BF_2 5.00 0.46 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27613 BF_2 530.31 16.41 1639 642912019 XP_008199062.1 1896 1.5e-209 PREDICTED: calcium uptake protein 3, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86XE3 901 1.5e-95 Calcium uptake protein 3, mitochondrial OS=Homo sapiens GN=MICU3 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202//PF12763 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27616 BF_2 252.37 1.61 6842 546681938 ERL91934.1 5335 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF06320//PF02244//PF12859//PF00057 GCN5-like protein 1 (GCN5L1)//Carboxypeptidase activation peptide//Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A GO:0006508 proteolysis GO:0004180//GO:0005515 carboxypeptidase activity//protein binding GO:0031083//GO:0005680 BLOC-1 complex//anaphase-promoting complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.27617 BF_2 1.00 0.31 422 270011242 EFA07690.1 224 2.9e-16 hypothetical protein TcasGA2_TC030763, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27618 BF_2 45.56 3.49 833 -- -- -- -- -- 642938590 XM_008201633.1 47 2.73362e-13 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X8, mRNA -- -- -- -- -- -- -- -- PF06459//PF15785 Ryanodine Receptor TM 4-6//Serine/threonine-protein kinase smg-1 GO:0016310//GO:0000184//GO:0009069//GO:0006816//GO:0006874 phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//serine family amino acid metabolic process//calcium ion transport//cellular calcium ion homeostasis GO:0005219//GO:0004674 ryanodine-sensitive calcium-release channel activity//protein serine/threonine kinase activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.27619 BF_2 52.00 1.75 1530 478257211 ENN77374.1 627 2.0e-62 hypothetical protein YQE_06199, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6NRD5 176 1.6e-11 Exonuclease 3'-5' domain-containing protein 1 OS=Xenopus laevis GN=exd1 PE=2 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding -- -- -- -- Cluster-8309.27620 BF_2 171.87 2.88 2780 646702398 KDR11610.1 775 2.5e-79 GTP-binding protein Rheb-like protein [Zootermopsis nevadensis] 556946329 XM_005986343.1 39 2.62711e-08 PREDICTED: Latimeria chalumnae GTP-binding protein Rheb-like (LOC102353752), mRNA K07208 RHEB Ras homolog enriched in brain http://www.genome.jp/dbget-bin/www_bget?ko:K07208 Q9VND8 675 4.0e-69 GTP-binding protein Rheb homolog OS=Drosophila melanogaster GN=Rheb PE=2 SV=1 PF00071//PF00025//PF01926//PF01637//PF08477//PF03193 Ras family//ADP-ribosylation factor family//50S ribosome-binding GTPase//Archaeal ATPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.27621 BF_2 356.29 5.64 2932 328722814 XP_001942735.2 1153 3.8e-123 PREDICTED: endothelin-converting enzyme 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P42893 533 1.2e-52 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.27622 BF_2 266.85 4.03 3054 328722814 XP_001942735.2 1153 4.0e-123 PREDICTED: endothelin-converting enzyme 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P42893 533 1.3e-52 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.27623 BF_2 11.37 0.74 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27624 BF_2 73.04 1.81 1972 676472292 XP_009059444.1 402 3.1e-36 hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea]>gi|556101324|gb|ESO89976.1| hypothetical protein LOTGIDRAFT_234081 [Lottia gigantea] -- -- -- -- -- -- -- -- -- Q5MCW4 395 8.3e-37 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF00096//PF13465//PF05443//PF13912//PF02892//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//C2H2-type zinc finger//BED zinc finger//zinc-finger C2H2-type GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.27625 BF_2 7.23 0.35 1159 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15704 Mitochondrial ATP synthase subunit GO:0009555 pollen development -- -- -- -- -- -- Cluster-8309.27626 BF_2 260.32 1.37 8262 270016796 EFA13242.1 3554 0.0e+00 hypothetical protein TcasGA2_TC001512 [Tribolium castaneum] 642938255 XM_008199910.1 478 0 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 1514 6.1e-166 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 PF01562//PF07988//PF01421 Reprolysin family propeptide//LMSTEN motif//Reprolysin (M12B) family zinc metalloprotease GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.27628 BF_2 100.00 20.71 489 642925814 XP_970128.3 398 2.2e-36 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 223 1.8e-17 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01073//PF00106//PF01370//PF12242 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0008210//GO:0008152 C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//estrogen metabolic process//metabolic process GO:0003854//GO:0003824//GO:0050662//GO:0016491//GO:0016616 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- -- -- Cluster-8309.27630 BF_2 19.02 0.88 1192 91095123 XP_970890.1 476 4.9e-45 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 333 7.8e-30 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF03857//PF00106 Colicin immunity protein//short chain dehydrogenase GO:0006955//GO:0030153//GO:0008152 immune response//bacteriocin immunity//metabolic process GO:0016491//GO:0015643 oxidoreductase activity//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.27632 BF_2 1721.18 30.80 2625 642925731 XP_008201510.1 490 2.6e-46 PREDICTED: snRNA-activating protein complex subunit 1-like [Tribolium castaneum]>gi|270008917|gb|EFA05365.1| hypothetical protein TcasGA2_TC015530 [Tribolium castaneum] 830186132 XM_004692871.2 69 5.21942e-25 PREDICTED: Condylura cristata vesicle-associated membrane protein 1 (synaptobrevin 1) (VAMP1), mRNA K13505 VAMP3 vesicle-associated membrane protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13505 O02495 252 4.2e-20 Synaptobrevin-1 OS=Caenorhabditis elegans GN=snb-1 PE=1 SV=1 PF01555//PF10717//PF00957 DNA methylase//Occlusion-derived virus envelope protein ODV-E18//Synaptobrevin GO:0016192//GO:0006306 vesicle-mediated transport//DNA methylation GO:0003677//GO:0008170 DNA binding//N-methyltransferase activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.27633 BF_2 106.25 2.00 2513 91082929 XP_972879.1 1013 5.6e-107 PREDICTED: ubiquitin-conjugating enzyme E2Q-like protein CG4502 [Tribolium castaneum]>gi|270007616|gb|EFA04064.1| hypothetical protein TcasGA2_TC014298 [Tribolium castaneum] 195117381 XM_002003190.1 85 6.36902e-34 Drosophila mojavensis GI17799 (Dmoj\GI17799), mRNA K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q9VM35 678 1.6e-69 Ubiquitin-conjugating enzyme E2Q-like protein CG4502 OS=Drosophila melanogaster GN=CG4502 PE=2 SV=1 PF05997 Nucleolar protein,Nop52 GO:0006364 rRNA processing GO:0016881 acid-amino acid ligase activity GO:0030688 preribosome, small subunit precursor KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.27634 BF_2 114.75 1.97 2727 91082929 XP_972879.1 1013 6.1e-107 PREDICTED: ubiquitin-conjugating enzyme E2Q-like protein CG4502 [Tribolium castaneum]>gi|270007616|gb|EFA04064.1| hypothetical protein TcasGA2_TC014298 [Tribolium castaneum] 195117381 XM_002003190.1 85 6.91431e-34 Drosophila mojavensis GI17799 (Dmoj\GI17799), mRNA K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q9VM35 678 1.8e-69 Ubiquitin-conjugating enzyme E2Q-like protein CG4502 OS=Drosophila melanogaster GN=CG4502 PE=2 SV=1 PF05997 Nucleolar protein,Nop52 GO:0006364 rRNA processing GO:0016881 acid-amino acid ligase activity GO:0030688 preribosome, small subunit precursor KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.27636 BF_2 1.00 2.88 271 642938419 XP_008199794.1 234 1.3e-17 PREDICTED: coleoptericin-like [Tribolium castaneum]>gi|270015406|gb|EFA11854.1| hypothetical protein TcasGA2_TC005096 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81592 444 2.4e-43 Acaloleptin A OS=Acalolepta luxuriosa PE=1 SV=2 PF06286 Coleoptericin GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-8309.27639 BF_2 16.00 0.36 2121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2764 BF_2 1.00 0.49 369 765144722 XP_011483321.1 251 1.9e-19 PREDICTED: transposase isoform X1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- Q9UJ78 202 3.7e-15 Zinc finger MYM-type protein 5 OS=Homo sapiens GN=ZMYM5 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27640 BF_2 245.09 1.78 6037 642915750 XP_008190789.1 4116 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.37904e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.6e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.27642 BF_2 97.65 9.31 726 642922287 XP_008193094.1 465 5.7e-44 PREDICTED: calcium uptake protein 1 homolog, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VEI2 313 9.8e-28 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27643 BF_2 462.68 4.57 4522 642922287 XP_008193094.1 1398 2.3e-151 PREDICTED: calcium uptake protein 1 homolog, mitochondrial isoform X2 [Tribolium castaneum] 827547479 XM_004926405.2 135 1.84862e-61 PREDICTED: Bombyx mori calcium uptake protein 1 homolog, mitochondrial-like (LOC101741664), mRNA -- -- -- -- A2VEI2 1235 7.5e-134 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 PF13202//PF03854//PF00036//PF12763//PF10591//PF13833//PF13405//PF13499 EF hand//P-11 zinc finger//EF hand//Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0008270//GO:0005509//GO:0003723//GO:0005515 zinc ion binding//calcium ion binding//RNA binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.27648 BF_2 62.67 0.93 3104 91076992 XP_975474.1 1215 2.6e-130 PREDICTED: ras-like protein 3 [Tribolium castaneum]>gi|270001761|gb|EEZ98208.1| hypothetical protein TcasGA2_TC000640 [Tribolium castaneum] 195387773 XM_002052531.1 54 1.3474e-16 Drosophila virilis GJ17614 (Dvir\GJ17614), mRNA K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 F1NHE9 771 3.3e-80 ATP-sensitive inward rectifier potassium channel 12 OS=Gallus gallus GN=KCNJ12 PE=1 SV=1 PF00071//PF01007//PF00025//PF00503//PF01926//PF08477//PF03193 Ras family//Inward rectifier potassium channel//ADP-ribosylation factor family//G-protein alpha subunit//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0006813//GO:0007165//GO:0007264//GO:0006184//GO:0007186 potassium ion transport//signal transduction//small GTPase mediated signal transduction//obsolete GTP catabolic process//G-protein coupled receptor signaling pathway GO:0003924//GO:0005242//GO:0031683//GO:0019001//GO:0004871//GO:0005525 GTPase activity//inward rectifier potassium channel activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTP binding GO:0016021//GO:0008076//GO:0016020 integral component of membrane//voltage-gated potassium channel complex//membrane KOG3827 Inward rectifier K+ channel Cluster-8309.27649 BF_2 551.64 10.67 2450 642912453 XP_008200868.1 2147 1.7e-238 PREDICTED: transferrin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02942 730 1.5e-75 Transferrin OS=Blaberus discoidalis PE=1 SV=1 PF09445 RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.27653 BF_2 169.89 1.35 5538 189241624 XP_001807794.1 2521 1.7e-281 PREDICTED: chondroitin sulfate synthase 1 isoform X2 [Tribolium castaneum] 194768964 XM_001966545.1 131 3.79399e-59 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1685 6.1e-186 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF13506//PF05679//PF01762//PF02434 Glycosyl transferase family 21//Chondroitin N-acetylgalactosaminyltransferase//Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0008376//GO:0016757 galactosyltransferase activity//acetylgalactosaminyltransferase activity//transferase activity, transferring glycosyl groups GO:0032580//GO:0016020 Golgi cisterna membrane//membrane KOG3588 Chondroitin synthase 1 Cluster-8309.27654 BF_2 91.49 1.13 3684 270003083 EEZ99530.1 2054 1.6e-227 hypothetical protein TcasGA2_TC000112 [Tribolium castaneum] -- -- -- -- -- K13117 DHX35 ATP-dependent RNA helicase DDX35 http://www.genome.jp/dbget-bin/www_bget?ko:K13117 Q9H5Z1 1282 2.2e-139 Probable ATP-dependent RNA helicase DHX35 OS=Homo sapiens GN=DHX35 PE=1 SV=2 PF00400//PF04408//PF01436 WD domain, G-beta repeat//Helicase associated domain (HA2)//NHL repeat -- -- GO:0005515//GO:0004386 protein binding//helicase activity -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.27660 BF_2 10.68 0.63 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27661 BF_2 703.17 6.43 4864 91090284 XP_971237.1 1565 1.1e-170 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 500 1.4e-48 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.27662 BF_2 32.00 1.01 1616 642935122 XP_008197897.1 2599 4.5e-291 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 224 2.18388e-111 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 332 1.4e-29 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.27665 BF_2 90.90 0.72 5539 270007176 EFA03624.1 2170 8.5e-241 hypothetical protein TcasGA2_TC013717 [Tribolium castaneum] 642922446 XM_008194952.1 244 5.79191e-122 PREDICTED: Tribolium castaneum titin-like (LOC655359), mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 1.2e-117 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF08172//PF00621 CASP C terminal//RhoGEF domain GO:0043087//GO:0035023//GO:0006891 regulation of GTPase activity//regulation of Rho protein signal transduction//intra-Golgi vesicle-mediated transport GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane KOG3531 Rho guanine nucleotide exchange factor CDEP Cluster-8309.27668 BF_2 1327.19 6.96 8259 270002738 EEZ99185.1 1670 1.2e-182 serine protease H6 [Tribolium castaneum] 462358611 APGK01030035.1 93 7.54224e-38 Dendroctonus ponderosae Seq01030045, whole genome shotgun sequence -- -- -- -- E1BLP6 751 1.8e-77 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 PF01388//PF04926//PF06090 ARID/BRIGHT DNA binding domain//Poly(A) polymerase predicted RNA binding domain//Inositol-pentakisphosphate 2-kinase GO:0043631 RNA polyadenylation GO:0003677//GO:0005524//GO:0003723//GO:0035299 DNA binding//ATP binding//RNA binding//inositol pentakisphosphate 2-kinase activity -- -- KOG2744 DNA-binding proteins Bright/BRCAA1/RBP1 and related proteins containing BRIGHT domain Cluster-8309.27669 BF_2 13.56 0.40 1721 478258940 ENN78915.1 687 2.4e-69 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q5F4B1 410 1.3e-38 Phosphoglycolate phosphatase OS=Gallus gallus GN=PGP PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.27671 BF_2 287.15 5.09 2647 189239598 XP_967831.2 1055 8.0e-112 PREDICTED: CAAX prenyl protease 2 [Tribolium castaneum] -- -- -- -- -- K08658 RCE1, FACE2 prenyl protein peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08658 Q9U1H8 668 2.5e-68 CAAX prenyl protease 2 OS=Drosophila melanogaster GN=Sras PE=2 SV=3 PF02517 CAAX protease self-immunity -- -- -- -- GO:0016020 membrane KOG4130 Prenyl protein protease Cluster-8309.27676 BF_2 12.44 0.55 1226 91090662 XP_974317.1 957 8.5e-101 PREDICTED: ubiquitin-like domain-containing CTD phosphatase 1 [Tribolium castaneum] -- -- -- -- -- K17618 UBLCP1 ubiquitin-like domain-containing CTD phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17618 Q6DI37 704 7.6e-73 Ubiquitin-like domain-containing CTD phosphatase 1 OS=Danio rerio GN=ublcp1 PE=2 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG1872 Ubiquitin-specific protease Cluster-8309.27678 BF_2 25.21 0.39 2996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27680 BF_2 279.45 3.84 3328 91091390 XP_973483.1 1946 4.8e-215 PREDICTED: gametogenetin-binding protein 2-like [Tribolium castaneum]>gi|270014166|gb|EFA10614.1| hypothetical protein TcasGA2_TC012875 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNG1 907 6.0e-96 Gametogenetin-binding protein 2-like OS=Drosophila melanogaster GN=CG2182 PE=2 SV=3 PF15337 Vascular protein family Vasculin-like 1 GO:0006351//GO:0045893 transcription, DNA-templated//positive regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.27681 BF_2 2.00 0.67 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27682 BF_2 730.31 12.48 2735 642929623 XP_008195908.1 441 1.3e-40 PREDICTED: vegetative cell wall protein gp1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01132 Elongation factor P (EF-P) OB domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.27683 BF_2 47.38 0.78 2822 91078176 XP_967241.1 2271 8.4e-253 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1711 3.0e-189 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006804//GO:0055114//GO:0006979 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- -- -- Cluster-8309.27684 BF_2 33.33 0.56 2776 242018392 XP_002429661.1 545 1.1e-52 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] 688552082 XM_009300990.1 38 9.43499e-08 PREDICTED: Danio rerio zinc finger protein 420-like (LOC100537687), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 O75373 527 5.8e-52 Zinc finger protein 737 OS=Homo sapiens GN=ZNF737 PE=2 SV=3 PF00096//PF13465//PF06467//PF13912//PF04810//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//MYM-type Zinc finger with FCS sequence motif//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.27685 BF_2 12.14 1.33 670 189237508 XP_972374.2 291 7.8e-24 PREDICTED: protein D2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P31729 247 4.1e-20 OV-16 antigen OS=Onchocerca volvulus GN=OV16 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.27687 BF_2 24.00 4.76 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01779 Ribosomal L29e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.27688 BF_2 28.61 2.04 874 642914372 XP_008201652.1 231 9.3e-17 PREDICTED: uncharacterized protein LOC659966 [Tribolium castaneum]>gi|270001589|gb|EEZ98036.1| hypothetical protein TcasGA2_TC000438 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27690 BF_2 245.84 8.69 1470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27693 BF_2 7.00 0.70 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27695 BF_2 18.92 0.45 2064 91089627 XP_973479.1 2254 5.8e-251 PREDICTED: histone-binding protein RBBP4 [Tribolium castaneum]>gi|270012612|gb|EFA09060.1| hypothetical protein TcasGA2_TC006775 [Tribolium castaneum] 820847485 XM_003693377.2 567 0 PREDICTED: Apis florea probable histone-binding protein Caf1 (LOC100871885), mRNA K10752 RBBP4, HAT2, CAF1, MIS16 histone-binding protein RBBP4 http://www.genome.jp/dbget-bin/www_bget?ko:K10752 Q24572 2171 1.0e-242 Probable histone-binding protein Caf1 OS=Drosophila melanogaster GN=Caf1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding GO:0005634 nucleus KOG0264 Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 Cluster-8309.27697 BF_2 837.04 8.47 4421 189240990 XP_968175.2 1469 1.3e-159 PREDICTED: serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform [Tribolium castaneum]>gi|270012986|gb|EFA09434.1| hypothetical protein TcasGA2_TC010646 [Tribolium castaneum] -- -- -- -- -- K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 P30153 728 4.5e-75 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Homo sapiens GN=PPP2R1A PE=1 SV=4 PF01365//PF06616//PF02985//PF03147 RIH domain//BsuBI/PstI restriction endonuclease C-terminus//HEAT repeat//Ferredoxin-fold anticodon binding domain GO:0006816//GO:0070588//GO:0009307//GO:0006571//GO:0008033//GO:0006432//GO:0009094//GO:0000162//GO:0006308 calcium ion transport//calcium ion transmembrane transport//DNA restriction-modification system//tyrosine biosynthetic process//tRNA processing//phenylalanyl-tRNA aminoacylation//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//DNA catabolic process GO:0005524//GO:0005262//GO:0009036//GO:0003677//GO:0005515//GO:0000049//GO:0004826//GO:0000287 ATP binding//calcium channel activity//Type II site-specific deoxyribonuclease activity//DNA binding//protein binding//tRNA binding//phenylalanine-tRNA ligase activity//magnesium ion binding GO:0009328//GO:0009359//GO:0016020 phenylalanine-tRNA ligase complex//Type II site-specific deoxyribonuclease complex//membrane KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.27698 BF_2 12.62 0.40 1605 642936948 XP_008198624.1 1442 6.4e-157 PREDICTED: transmembrane protein 39A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNY8 647 4.1e-66 Transmembrane protein 39A-B OS=Xenopus laevis GN=tmem39a-b PE=2 SV=1 PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- KOG3828 Uncharacterized conserved protein Cluster-8309.27699 BF_2 68.00 2.90 1268 91091556 XP_966788.1 1132 4.5e-121 PREDICTED: coiled-coil domain-containing protein 130 homolog [Tribolium castaneum]>gi|270000917|gb|EEZ97364.1| hypothetical protein TcasGA2_TC011186 [Tribolium castaneum] -- -- -- -- -- K13115 CCDC130 coiled-coil domain-containing protein 130 http://www.genome.jp/dbget-bin/www_bget?ko:K13115 Q7K0F0 926 1.4e-98 Coiled-coil domain-containing protein 130 homolog OS=Drosophila melanogaster GN=CG15084 PE=2 SV=1 PF00569 Zinc finger, ZZ type -- -- GO:0008270 zinc ion binding -- -- KOG2990 C2C2-type Zn-finger protein Cluster-8309.27702 BF_2 71.56 1.31 2568 642927029 XP_008195110.1 1077 2.2e-114 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U182 182 5.4e-12 CREB-regulated transcription coactivator 2 OS=Mus musculus GN=Crtc2 PE=1 SV=2 PF00170//PF12884 bZIP transcription factor//Transducer of regulated CREB activity, N terminus GO:0051289//GO:0006355 protein homotetramerization//regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0008140 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//cAMP response element binding protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.27704 BF_2 133.00 15.77 640 478259232 ENN79134.1 381 2.7e-34 hypothetical protein YQE_04320, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27706 BF_2 395.23 5.02 3580 642935662 XP_008198105.1 869 4.0e-90 PREDICTED: cytochrome b reductase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 2.7e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF01292//PF03188//PF00033 Prokaryotic cytochrome b561//Eukaryotic cytochrome b561//Cytochrome b/b6/petB GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0009055 electron carrier activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.27707 BF_2 2.00 1.60 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27710 BF_2 58.61 1.55 1869 282158077 NP_001164082.1 1654 2.0e-181 spatzle 6 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27711 BF_2 51.61 1.27 1993 642914252 XP_008201607.1 1658 7.2e-182 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|270001550|gb|EEZ97997.1| hypothetical protein TcasGA2_TC000395 [Tribolium castaneum] -- -- -- -- -- K00741 B3GNT1, B3GNT2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00741 O43505 417 2.4e-39 Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens GN=B4GAT1 PE=1 SV=1 PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.27712 BF_2 145.98 11.93 799 91094239 XP_968325.1 484 3.9e-46 PREDICTED: ragulator complex protein LAMTOR3 [Tribolium castaneum]>gi|270016276|gb|EFA12722.1| hypothetical protein TcasGA2_TC002357 [Tribolium castaneum] -- -- -- -- -- K04370 MP1, MAP2K1IP1 mitogen-activated protein kinase kinase 1 interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04370 Q7T0V2 349 7.3e-32 Ragulator complex protein LAMTOR3-A OS=Xenopus laevis GN=lamtor3-a PE=2 SV=1 PF08923 Mitogen-activated protein kinase kinase 1 interacting GO:0032006 regulation of TOR signaling -- -- -- -- -- -- Cluster-8309.27713 BF_2 41.27 1.48 1455 646713645 KDR17927.1 356 5.0e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 6.0e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27714 BF_2 39.14 0.56 3191 642928441 XP_008193786.1 274 3.5e-21 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27715 BF_2 12.00 0.39 1583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27717 BF_2 586.93 8.27 3255 332375404 AEE62843.1 1194 7.5e-128 unknown [Dendroctonus ponderosae] 642934692 XM_008199551.1 353 0 PREDICTED: Tribolium castaneum CUGBP Elav-like family member 1 (LOC660275), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q9IBD0 376 2.2e-34 CUGBP Elav-like family member 1 OS=Danio rerio GN=celf1 PE=1 SV=1 PF16367//PF08675//PF00076 RNA recognition motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0003676//GO:0004535//GO:0046872//GO:0003723 nucleic acid binding//poly(A)-specific ribonuclease activity//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.27719 BF_2 323.67 7.32 2137 642930395 XP_008196381.1 2106 8.7e-234 PREDICTED: SH3 domain-binding protein 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH82 583 1.4e-58 SH3 domain-binding protein 5-like OS=Xenopus tropicalis GN=sh3bp5l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.27720 BF_2 644.00 10.93 2753 642938847 XP_008200089.1 2696 4.3e-302 PREDICTED: pre-rRNA-processing protein TSR1 homolog [Tribolium castaneum]>gi|270016043|gb|EFA12491.1| hypothetical protein TcasGA2_TC012891 [Tribolium castaneum] 525018632 XM_005056799.1 48 2.58292e-13 PREDICTED: Ficedula albicollis TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) (TSR1), transcript variant X2, mRNA K14799 TSR1 pre-rRNA-processing protein TSR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14799 Q2NL82 1661 1.8e-183 Pre-rRNA-processing protein TSR1 homolog OS=Homo sapiens GN=TSR1 PE=1 SV=1 PF08142//PF01749 AARP2CN (NUC121) domain//Importin beta binding domain GO:0042254//GO:0015031//GO:0006606 ribosome biogenesis//protein transport//protein import into nucleus GO:0008565 protein transporter activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG1980 Uncharacterized conserved protein Cluster-8309.27722 BF_2 159.28 1.92 3760 478253990 ENN74282.1 1734 2.1e-190 hypothetical protein YQE_09254, partial [Dendroctonus ponderosae]>gi|546673736|gb|ERL85292.1| hypothetical protein D910_02713 [Dendroctonus ponderosae] -- -- -- -- -- K06639 CDC14 cell division cycle 14 http://www.genome.jp/dbget-bin/www_bget?ko:K06639 Q6GQT0 1212 2.9e-131 Dual specificity protein phosphatase CDC14A OS=Mus musculus GN=Cdc14a PE=2 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.27727 BF_2 28.09 0.34 3787 478253154 ENN73525.1 1577 3.4e-172 hypothetical protein YQE_09776, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 854 9.5e-90 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01370//PF06756//PF03015 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Chorion protein S19 C-terminal//Male sterility protein GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0007275//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//multicellular organismal development//estrogen metabolic process GO:0080019//GO:0016616//GO:0003854//GO:0003824//GO:0050662 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding GO:0042600 chorion KOG1221 Acyl-CoA reductase Cluster-8309.27728 BF_2 316.10 10.31 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27730 BF_2 16.96 0.75 1233 91091818 XP_966528.1 682 6.6e-69 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 434 1.6e-41 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF00060 Ligand-gated ion channel GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0004970//GO:0005216 ionotropic glutamate receptor activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.27731 BF_2 1269.41 19.15 3060 270006239 EFA02687.1 3258 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1457 9.2e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02180//PF02854//PF02020 Bcl-2 homology region 4//MIF4G domain//eIF4-gamma/eIF5/eIF2-epsilon GO:0042981 regulation of apoptotic process GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.27733 BF_2 723.34 16.92 2075 478257813 ENN77956.1 1793 1.7e-197 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 1.1e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27734 BF_2 146.95 1.46 4498 642937240 XP_008198752.1 2109 8.2e-234 PREDICTED: chondroitin sulfate synthase 1 isoform X1 [Tribolium castaneum] 194768964 XM_001966545.1 122 3.09869e-54 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1272 3.8e-138 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF02434//PF01762//PF05679//PF13506 Fringe-like//Galactosyltransferase//Chondroitin N-acetylgalactosaminyltransferase//Glycosyl transferase family 21 GO:0006486 protein glycosylation GO:0008378//GO:0008376//GO:0016757 galactosyltransferase activity//acetylgalactosaminyltransferase activity//transferase activity, transferring glycosyl groups GO:0032580//GO:0016020 Golgi cisterna membrane//membrane KOG3588 Chondroitin synthase 1 Cluster-8309.27736 BF_2 147.00 13.95 728 751795220 XP_011207369.1 345 4.7e-30 PREDICTED: uncharacterized protein LOC105229022 [Bactrocera dorsalis] -- -- -- -- -- K06560 MRC mannose receptor, C type http://www.genome.jp/dbget-bin/www_bget?ko:K06560 P22897 178 4.4e-12 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27737 BF_2 420.00 33.48 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27738 BF_2 22.55 0.78 1497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27739 BF_2 9.00 0.88 713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27742 BF_2 324.37 2.16 6568 642923720 XP_008193855.1 1439 5.9e-156 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0FGR8 565 5.4e-56 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.27746 BF_2 312.52 7.86 1951 546682805 ERL92694.1 1690 1.4e-185 hypothetical protein D910_10005 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01939 866 2.0e-91 Protein misato OS=Drosophila melanogaster GN=mst PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG2530 Members of tubulin/FtsZ family Cluster-8309.27747 BF_2 78.00 4.56 1003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27748 BF_2 1.04 0.31 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11789 Zinc-finger of the MIZ type in Nse subunit -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.2775 BF_2 29.00 0.45 2996 642912280 XP_967562.2 1318 2.9e-142 PREDICTED: galactoside 2-alpha-L-fucosyltransferase 3-like [Tribolium castaneum] 642912279 XM_962469.2 221 1.90171e-109 PREDICTED: Tribolium castaneum galactoside 2-alpha-L-fucosyltransferase 3-like (LOC655912), mRNA K00718 FUT1_2 galactoside 2-L-fucosyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00718 P97353 305 3.4e-26 Galactoside 2-alpha-L-fucosyltransferase 3 OS=Mus musculus GN=Sec1 PE=2 SV=1 PF01531//PF05024 Glycosyl transferase family 11//N-acetylglucosaminyl transferase component (Gpi1) GO:0009247//GO:0006506//GO:0005975//GO:0001575 glycolipid biosynthetic process//GPI anchor biosynthetic process//carbohydrate metabolic process//globoside metabolic process GO:0017176//GO:0008107 phosphatidylinositol N-acetylglucosaminyltransferase activity//galactoside 2-alpha-L-fucosyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.27750 BF_2 3.00 2.60 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27751 BF_2 369.20 4.50 3719 642930416 XP_008196392.1 1551 3.4e-169 PREDICTED: stAR-related lipid transfer protein 3 [Tribolium castaneum]>gi|270011106|gb|EFA07554.1| Start1 [Tribolium castaneum] 768450242 XM_011568950.1 44 5.85883e-11 PREDICTED: Plutella xylostella MLN64 N-terminal domain homolog (LOC105396938), mRNA -- -- -- -- Q9DFS4 623 5.7e-63 StAR-related lipid transfer protein 3 OS=Danio rerio GN=stard3 PE=2 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG3845 MLN, STAR and related lipid-binding proteins Cluster-8309.27752 BF_2 1.02 0.45 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04824 Conserved region of Rad21 / Rec8 like protein -- -- -- -- GO:0000228 nuclear chromosome -- -- Cluster-8309.27753 BF_2 38.00 2.86 843 321473458 EFX84425.1 547 2.0e-53 hypothetical protein DAPPUDRAFT_230610 [Daphnia pulex] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P29522 499 3.1e-49 Elongation factor 1-beta' OS=Bombyx mori PE=1 SV=2 PF00736 EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.27754 BF_2 260.00 9.08 1485 644993225 XP_008203138.1 149 5.1e-07 PREDICTED: mucin-12 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- P35074 133 1.5e-06 DNA-directed RNA polymerase II subunit RPB1 OS=Caenorhabditis briggsae GN=rpb-1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27755 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27758 BF_2 684.00 7.62 4040 546681035 ERL91200.1 1188 4.6e-127 hypothetical protein D910_08539 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8K1A0 628 1.6e-63 Methyltransferase-like protein 5 OS=Mus musculus GN=Mettl5 PE=2 SV=2 PF05175//PF02390//PF00628//PF15925//PF03602//PF02384//PF09445 Methyltransferase small domain//Putative methyltransferase//PHD-finger//SOSS complex subunit C//Conserved hypothetical protein 95//N-6 DNA Methylase//RNA cap guanine-N2 methyltransferase GO:0009451//GO:0006400//GO:0006306//GO:0009452//GO:0001510//GO:0008033//GO:0006974//GO:0031167//GO:0006281 RNA modification//tRNA modification//DNA methylation//7-methylguanosine RNA capping//RNA methylation//tRNA processing//cellular response to DNA damage stimulus//rRNA methylation//DNA repair GO:0008176//GO:0003677//GO:0005515//GO:0008168//GO:0008170 tRNA (guanine-N7-)-methyltransferase activity//DNA binding//protein binding//methyltransferase activity//N-methyltransferase activity GO:0005634//GO:0070876 nucleus//SOSS complex KOG3420 Predicted RNA methylase Cluster-8309.2776 BF_2 2.00 0.73 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27761 BF_2 3.00 0.54 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27762 BF_2 9.10 0.81 759 91090714 XP_975034.1 255 1.3e-19 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 229 5.6e-18 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27763 BF_2 410.00 10.56 1912 478257020 ENN77184.1 774 2.2e-79 hypothetical protein YQE_06322, partial [Dendroctonus ponderosae]>gi|546673257|gb|ERL84895.1| hypothetical protein D910_02318 [Dendroctonus ponderosae] -- -- -- -- -- K10580 UBE2N, BLU, UBC13 ubiquitin-conjugating enzyme E2 N http://www.genome.jp/dbget-bin/www_bget?ko:K10580 P35128 591 1.5e-59 Ubiquitin-conjugating enzyme E2 N OS=Drosophila melanogaster GN=ben PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.27764 BF_2 23.61 7.92 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27767 BF_2 3.58 0.31 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27769 BF_2 47.00 6.90 572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04851 Type III restriction enzyme, res subunit -- -- GO:0016787//GO:0003677//GO:0005524 hydrolase activity//DNA binding//ATP binding -- -- -- -- Cluster-8309.27772 BF_2 127.58 1.58 3675 642916459 XP_008191036.1 2113 2.3e-234 PREDICTED: sestrin homolog [Tribolium castaneum]>gi|642916461|ref|XP_008191037.1| PREDICTED: sestrin homolog [Tribolium castaneum] 642916460 XM_008192815.1 526 0 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58003 755 2.8e-78 Sestrin-1 OS=Xenopus laevis GN=sesn1 PE=2 SV=1 PF04636 PA26 p53-induced protein (sestrin) GO:1901031 regulation of response to reactive oxygen species -- -- GO:0005634 nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.27773 BF_2 9490.42 136.67 3192 478254444 ENN74696.1 1939 3.0e-214 hypothetical protein YQE_08813, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIL5 988 2.3e-105 Beta-galactosidase-1-like protein 3 OS=Rattus norvegicus GN=Glb1l3 PE=2 SV=1 PF00560//PF02449//PF13855//PF00150 Leucine Rich Repeat//Beta-galactosidase//Leucine rich repeat//Cellulase (glycosyl hydrolase family 5) GO:0006687//GO:0046486//GO:0005975//GO:0006012//GO:0006027 glycosphingolipid metabolic process//glycerolipid metabolic process//carbohydrate metabolic process//galactose metabolic process//glycosaminoglycan catabolic process GO:0004553//GO:0004565//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//beta-galactosidase activity//protein binding GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.27774 BF_2 9.00 0.39 1258 82795527 ABB91677.1 647 7.7e-65 arthrodial cuticle protein AMP16.5 [Callinectes sapidus] 82795526 DQ288152.1 467 0 Callinectes sapidus arthrodial cuticle protein AMP16.5 mRNA, complete cds -- -- -- -- P81577 303 2.5e-26 Cuticle protein AM1199 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.27775 BF_2 50.00 5.54 665 -- -- -- -- -- 392303562 JX102595.1 278 8.35657e-142 Scylla paramamosain microsatellite Spm24 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27776 BF_2 97.31 0.98 4421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27778 BF_2 120.00 3.45 1744 170051568 XP_001861822.1 233 1.1e-16 predicted protein [Culex quinquefasciatus]>gi|167872759|gb|EDS36142.1| predicted protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.27779 BF_2 914.40 17.98 2415 91077394 XP_975293.1 2103 2.2e-233 PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|642913902|ref|XP_008201207.1| PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|270001645|gb|EEZ98092.1| hypothetical protein TcasGA2_TC000505 [Tribolium castaneum] -- -- -- -- -- K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 P52170 1420 1.4e-155 Importin subunit alpha-5 OS=Xenopus laevis GN=kpna1 PE=1 SV=2 PF11698//PF00514//PF01602//PF02985//PF01749//PF10508 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//HEAT repeat//Importin beta binding domain//Proteasome non-ATPase 26S subunit GO:0043248//GO:0006606//GO:0015031//GO:0006886//GO:0015991//GO:0016192 proteasome assembly//protein import into nucleus//protein transport//intracellular protein transport//ATP hydrolysis coupled proton transport//vesicle-mediated transport GO:0008565//GO:0016820//GO:0005515 protein transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005737//GO:0030117//GO:0005634//GO:0000221 cytoplasm//membrane coat//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain KOG0166 Karyopherin (importin) alpha Cluster-8309.2778 BF_2 20.00 0.74 1416 642919725 XP_008192040.1 958 7.5e-101 PREDICTED: uncharacterized protein LOC103312654 [Tribolium castaneum]>gi|270005899|gb|EFA02347.1| hypothetical protein TcasGA2_TC008017 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05393//PF07525 Human adenovirus early E3A glycoprotein//SOCS box GO:0035556 intracellular signal transduction -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27785 BF_2 80.20 0.99 3681 642928441 XP_008193786.1 225 1.9e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02148 Zn-finger in ubiquitin-hydrolases and other protein -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.27787 BF_2 45.00 1.43 1604 768956561 XP_003977419.2 688 1.7e-69 PREDICTED: LOW QUALITY PROTEIN: histone H3.3 [Takifugu rubripes] 835961372 XM_012922313.1 242 2.13686e-121 PREDICTED: Maylandia zebra histone H3.3 (LOC101481297), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P84249 676 1.8e-69 Histone H3.3 OS=Drosophila melanogaster GN=His3.3A PE=1 SV=2 PF00125//PF15715 Core histone H2A/H2B/H3/H4//PCNA-associated factor GO:0006974//GO:0051726 cellular response to DNA damage stimulus//regulation of cell cycle GO:0003677 DNA binding -- -- KOG1745 Histones H3 and H4 Cluster-8309.27791 BF_2 266.68 3.44 3529 546685279 ERL94806.1 3262 0.0e+00 hypothetical protein D910_12080 [Dendroctonus ponderosae] 815898007 XM_003485762.2 360 0 PREDICTED: Bombus impatiens cullin-4A (LOC100740815), mRNA K10609 CUL4 cullin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10609 A2A432 2575 2.4e-289 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 PF00888//PF07516 Cullin family//SecA Wing and Scaffold domain GO:0017038//GO:0006511 protein import//ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0016020 membrane KOG2166 Cullins Cluster-8309.27792 BF_2 323.12 4.12 3568 546685279 ERL94806.1 3262 0.0e+00 hypothetical protein D910_12080 [Dendroctonus ponderosae] 815898007 XM_003485762.2 360 0 PREDICTED: Bombus impatiens cullin-4A (LOC100740815), mRNA K10609 CUL4 cullin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10609 A2A432 2575 2.5e-289 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 PF07516//PF00888 SecA Wing and Scaffold domain//Cullin family GO:0006511//GO:0017038 ubiquitin-dependent protein catabolic process//protein import GO:0031625 ubiquitin protein ligase binding GO:0016020 membrane KOG2166 Cullins Cluster-8309.27793 BF_2 6.83 0.62 749 270001539 EEZ97986.1 181 5.0e-11 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] -- -- -- -- -- K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 -- -- -- -- -- -- -- -- -- -- -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.27794 BF_2 46.43 2.35 1114 871263751 XP_012943684.1 152 1.7e-07 PREDICTED: cell wall protein IFF6-like isoform X2 [Aplysia californica] -- -- -- -- -- -- -- -- -- O85467 132 1.5e-06 Spore germination protein GerIA OS=Bacillus cereus GN=gerIA PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27795 BF_2 2903.94 41.18 3237 289474530 ADC97876.1 1920 4.9e-212 glycoside hydrolase family 31 [Chrysomela tremula] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 891 4.2e-94 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.27796 BF_2 128186.57 6938.54 1060 871263751 XP_012943684.1 152 1.6e-07 PREDICTED: cell wall protein IFF6-like isoform X2 [Aplysia californica] -- -- -- -- -- -- -- -- -- O85467 132 1.4e-06 Spore germination protein GerIA OS=Bacillus cereus GN=gerIA PE=3 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27797 BF_2 51.91 0.34 6644 642925075 XP_008194159.1 1794 4.1e-197 PREDICTED: uncharacterized protein LOC658431 isoform X3 [Tribolium castaneum] 462390187 APGK01018906.1 55 8.06512e-17 Dendroctonus ponderosae Seq01018916, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF04512//PF04988//PF13465 Baculovirus polyhedron envelope protein, PEP, N terminus//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain -- -- GO:0046872//GO:0005198//GO:0003677 metal ion binding//structural molecule activity//DNA binding GO:0019031//GO:0019028//GO:0005634 viral envelope//viral capsid//nucleus -- -- Cluster-8309.27802 BF_2 253.10 10.74 1273 91084021 XP_975350.1 307 2.1e-25 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 820852256 XM_003694739.2 73 1.49092e-27 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX23 (LOC100863532), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q5RC67 212 8.9e-16 Probable ATP-dependent RNA helicase DDX23 OS=Pongo abelii GN=DDX23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.27803 BF_2 131.00 8.41 939 91082839 XP_969776.1 693 2.7e-70 PREDICTED: 39S ribosomal protein L10, mitochondrial [Tribolium castaneum]>gi|270007593|gb|EFA04041.1| hypothetical protein TcasGA2_TC014272 [Tribolium castaneum] -- -- -- -- -- K02864 RP-L10, MRPL10, rplJ large subunit ribosomal protein L10 http://www.genome.jp/dbget-bin/www_bget?ko:K02864 Q29NV5 473 3.6e-46 39S ribosomal protein L10, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL10 PE=3 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular -- -- Cluster-8309.27805 BF_2 245.35 11.04 1217 189234118 XP_001811130.1 610 1.5e-60 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] 153907106 AK262902.1 41 8.75093e-10 Gryllus bimaculatus mRNA, GBcontig09763 -- -- -- -- -- -- -- -- PF05757 Oxygen evolving enhancer protein 3 (PsbQ) GO:0015979 photosynthesis GO:0005509 calcium ion binding GO:0009654//GO:0019898//GO:0009523 photosystem II oxygen evolving complex//extrinsic component of membrane//photosystem II -- -- Cluster-8309.27806 BF_2 65.38 0.86 3476 332373510 AEE61896.1 429 4.1e-39 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4QBN3 168 3.1e-10 Facilitated trehalose transporter Tret1-2 homolog OS=Drosophila simulans GN=Tret1-2 PE=3 SV=1 PF00636//PF08120//PF00083 Ribonuclease III domain//Tamulustoxin family//Sugar (and other) transporter GO:0055085//GO:0009405//GO:0006810//GO:0051252//GO:0006396 transmembrane transport//pathogenesis//transport//regulation of RNA metabolic process//RNA processing GO:0022857//GO:0003723//GO:0019870//GO:0004525 transmembrane transporter activity//RNA binding//potassium channel inhibitor activity//ribonuclease III activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.27807 BF_2 750.68 5.77 5732 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.23384e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 D3YZP9 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Mus musculus GN=Ccdc6 PE=1 SV=1 PF04434//PF04551//PF04647 SWIM zinc finger//GcpE protein//Accessory gene regulator B GO:0009372//GO:0055114//GO:0009405//GO:0016114 quorum sensing//oxidation-reduction process//pathogenesis//terpenoid biosynthetic process GO:0008270//GO:0008233//GO:0046429 zinc ion binding//peptidase activity//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.27808 BF_2 45.00 68.59 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27809 BF_2 52.97 5.67 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27810 BF_2 157.87 1.34 5217 642916067 XP_970503.2 1479 1.1e-160 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270004116|gb|EFA00564.1| hypothetical protein TcasGA2_TC003434 [Tribolium castaneum] -- -- -- -- -- K14856 SDA1, SDAD1 protein SDA1 http://www.genome.jp/dbget-bin/www_bget?ko:K14856 Q7KKH3 1106 7.9e-119 Protein SDA1 homolog OS=Drosophila melanogaster GN=Mys45A PE=1 SV=1 PF07690//PF06839//PF01733//PF01306 Major Facilitator Superfamily//GRF zinc finger//Nucleoside transporter//LacY proton/sugar symporter GO:0055085//GO:0015858//GO:0006810 transmembrane transport//nucleoside transport//transport GO:0008270//GO:0005337 zinc ion binding//nucleoside transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2229 Protein required for actin cytoskeleton organization and cell cycle progression Cluster-8309.27814 BF_2 335.52 6.43 2469 642920044 XP_008192181.1 163 2.0e-08 PREDICTED: uncharacterized protein LOC103312680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.27819 BF_2 43.02 1.81 1284 459485591 AGG68958.1 1339 4.5e-145 prohibitin-1 [Leptinotarsa decemlineata] 459485590 JX275964.1 294 2.10899e-150 Leptinotarsa decemlineata prohibitin-1 mRNA, complete cds K17080 PHB1 prohibitin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17080 P24156 1162 6.2e-126 Protein l(2)37Cc OS=Drosophila melanogaster GN=l(2)37Cc PE=2 SV=2 PF03242 Late embryogenesis abundant protein GO:0006950 response to stress -- -- -- -- KOG3083 Prohibitin Cluster-8309.27820 BF_2 111.00 5.06 1204 620695583 AHY22513.1 779 3.7e-80 ubiquitin C, partial [Dastarcus helophoroides] -- -- -- -- -- K06688 UBE2C, UBC11 ubiquitin-conjugating enzyme E2 C http://www.genome.jp/dbget-bin/www_bget?ko:K06688 Q9VTY6 588 2.1e-59 Ubiquitin-conjugating enzyme E2 C OS=Drosophila melanogaster GN=vih PE=1 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005515 protein binding -- -- KOG0421 Ubiquitin-protein ligase Cluster-8309.27821 BF_2 57.97 0.64 4087 91080341 XP_974659.1 822 1.3e-84 PREDICTED: ADP-ribosylation factor GTPase-activating protein 2 [Tribolium castaneum]>gi|270005715|gb|EFA02163.1| hypothetical protein TcasGA2_TC007817 [Tribolium castaneum] -- -- -- -- -- K12493 ARFGAP2_3 ADP-ribosylation factor GTPase-activating protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12493 Q4R4C9 536 7.7e-53 ADP-ribosylation factor GTPase-activating protein 3 OS=Macaca fascicularis GN=ARFGAP3 PE=2 SV=1 PF01412//PF02130 Putative GTPase activating protein for Arf//Uncharacterized protein family UPF0054 GO:0006364 rRNA processing GO:0004222//GO:0005096 metalloendopeptidase activity//GTPase activator activity -- -- KOG0706 Predicted GTPase-activating protein Cluster-8309.27822 BF_2 134.00 6.78 1114 642923812 XP_974895.2 1188 1.3e-127 PREDICTED: probable tRNA(His) guanylyltransferase [Tribolium castaneum] -- -- -- -- -- K10761 THG1 tRNA(His) guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10761 Q9V3N8 855 2.1e-90 Probable tRNA(His) guanylyltransferase OS=Drosophila melanogaster GN=l(2)35Bc PE=2 SV=1 PF04446 tRNAHis guanylyltransferase GO:0006400 tRNA modification GO:0008193//GO:0000287 tRNA guanylyltransferase activity//magnesium ion binding -- -- KOG2721 Uncharacterized conserved protein Cluster-8309.27824 BF_2 427.48 15.33 1454 642932836 XP_008197006.1 1295 6.5e-140 PREDICTED: uncharacterized protein LOC663161 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27827 BF_2 109.20 0.70 6831 642931369 XP_008196550.1 7220 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931368 XM_008198328.1 1020 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X6, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5900 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF07353//PF10390//PF05014//PF05171//PF00498//PF00225//PF00959 Uroplakin II//RNA polymerase II elongation factor ELL//Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//FHA domain//Kinesin motor domain//Phage lysozyme GO:0005975//GO:0006826//GO:0007017//GO:0061024//GO:0009159//GO:0009253//GO:0007018//GO:0006206//GO:0006368//GO:0016998 carbohydrate metabolic process//iron ion transport//microtubule-based process//membrane organization//deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process//microtubule-based movement//pyrimidine nucleobase metabolic process//transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process GO:0050144//GO:0005524//GO:0008017//GO:0005515//GO:0003777//GO:0003796//GO:0070694 nucleoside deoxyribosyltransferase activity//ATP binding//microtubule binding//protein binding//microtubule motor activity//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity GO:0045298//GO:0005874//GO:0030176//GO:0008023 tubulin complex//microtubule//integral component of endoplasmic reticulum membrane//transcription elongation factor complex KOG0245 Kinesin-like protein Cluster-8309.27829 BF_2 2599.35 17.46 6515 91091256 XP_968850.1 1918 1.7e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.3e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF01398//PF00180//PF04117 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Isocitrate/isopropylmalate dehydrogenase//Mpv17 / PMP22 family GO:0006749//GO:0006102//GO:0019643//GO:0006099//GO:0055114 glutathione metabolic process//isocitrate metabolic process//reductive tricarboxylic acid cycle//tricarboxylic acid cycle//oxidation-reduction process GO:0005515//GO:0016616//GO:0051287//GO:0000287//GO:0004450 protein binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//magnesium ion binding//isocitrate dehydrogenase (NADP+) activity GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.27830 BF_2 213.00 12.08 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27838 BF_2 466.23 6.08 3496 642927860 XP_008195428.1 2686 7.9e-301 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X1 [Tribolium castaneum] 662183442 XM_008489250.1 117 1.44614e-51 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA K13297 PTPRT receptor-type tyrosine-protein phosphatase T http://www.genome.jp/dbget-bin/www_bget?ko:K13297 Q99M80 1000 1.0e-106 Receptor-type tyrosine-protein phosphatase T OS=Mus musculus GN=Ptprt PE=2 SV=2 PF00102//PF00041//PF00782//PF00641 Protein-tyrosine phosphatase//Fibronectin type III domain//Dual specificity phosphatase, catalytic domain//Zn-finger in Ran binding protein and others GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0005515//GO:0008138//GO:0004725 zinc ion binding//protein binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.27840 BF_2 1476.97 51.93 1477 270009427 EFA05875.1 831 4.2e-86 hypothetical protein TcasGA2_TC008684 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48815 257 6.2e-21 Alcohol dehydrogenase 2 OS=Ceratitis capitata GN=ADH2 PE=3 SV=1 PF01370//PF00106//PF01073 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008152//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.27841 BF_2 23.35 0.37 2908 642929814 XP_008195987.1 526 1.9e-50 PREDICTED: E3 ubiquitin-protein ligase Topors-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10631 TOPORS E3 ubiquitin-protein ligase Topors http://www.genome.jp/dbget-bin/www_bget?ko:K10631 Q80Z37 199 6.5e-14 E3 ubiquitin-protein ligase Topors OS=Mus musculus GN=Topors PE=1 SV=1 PF05793//PF00257//PF01480 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Dehydrin//PWI domain GO:0009415//GO:0006367//GO:0032968//GO:0006397//GO:0006950 response to water//transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter//mRNA processing//response to stress GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.27845 BF_2 87.43 5.46 957 478252070 ENN72501.1 747 1.5e-76 hypothetical protein YQE_10842, partial [Dendroctonus ponderosae] 831293719 XM_012823057.1 42 1.90054e-10 PREDICTED: Clupea harengus cullin 2 (cul2), mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 553 1.9e-55 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.27851 BF_2 5.00 1.14 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27852 BF_2 3.00 0.89 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27853 BF_2 23.75 0.43 2623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27855 BF_2 7.68 0.38 1135 730049052 AIZ08896.1 464 1.2e-43 takeout, partial [Locusta migratoria] -- -- -- -- -- -- -- -- -- Q9VBV3 236 1.3e-18 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.27856 BF_2 41.00 0.95 2096 815923661 XP_012246577.1 144 2.7e-06 PREDICTED: piggyBac transposable element-derived protein 4-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27857 BF_2 44.96 0.82 2595 189238410 XP_001813192.1 388 1.7e-34 PREDICTED: uncharacterized protein LOC100141684 [Tribolium castaneum]>gi|270008536|gb|EFA04984.1| hypothetical protein TcasGA2_TC015062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.27859 BF_2 357.84 3.45 4622 642923482 XP_008193528.1 1562 2.3e-170 PREDICTED: hyccin [Tribolium castaneum] 642923486 XM_008195309.1 166 1.10565e-78 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA -- -- -- -- Q9BYI3 417 5.5e-39 Hyccin OS=Homo sapiens GN=FAM126A PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.27861 BF_2 6.00 4.39 338 123494860 XP_001326609.1 231 3.6e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121909526|gb|EAY14386.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 189 1.1e-13 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27862 BF_2 10.86 0.31 1758 91093675 XP_969585.1 280 3.9e-22 PREDICTED: traB domain-containing protein [Tribolium castaneum]>gi|270008075|gb|EFA04523.1| hypothetical protein TcasGA2_TC016318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27866 BF_2 395.91 2.60 6650 642915750 XP_008190789.1 4165 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.82411e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.8e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.27867 BF_2 218.00 12.26 1031 478255767 ENN75976.1 230 1.4e-16 hypothetical protein YQE_07509, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27869 BF_2 4.00 0.45 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.27872 BF_2 1535.85 16.08 4282 91089973 XP_973833.1 4993 0.0e+00 PREDICTED: exportin-1 [Tribolium castaneum]>gi|270013547|gb|EFA09995.1| hypothetical protein TcasGA2_TC012162 [Tribolium castaneum] 462343018 APGK01035523.1 865 0 Dendroctonus ponderosae Seq01035533, whole genome shotgun sequence K14290 XPO1, CRM1 exportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14290 Q80U96 4220 0.0e+00 Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008536//GO:0008565 Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.27873 BF_2 736.47 6.53 5004 642939010 XP_008197770.1 3998 0.0e+00 PREDICTED: exportin-4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0E2 1978 5.8e-220 Exportin-4 OS=Homo sapiens GN=XPO4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily) Cluster-8309.27874 BF_2 52.31 0.83 2930 478261784 ENN80919.1 1237 6.9e-133 hypothetical protein YQE_02668, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IUS5 436 2.2e-41 Epoxide hydrolase 4 OS=Homo sapiens GN=EPHX4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4178 Soluble epoxide hydrolase Cluster-8309.27878 BF_2 2.00 0.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27880 BF_2 155.72 14.58 734 642921130 XP_975383.3 522 1.4e-50 PREDICTED: glutaredoxin-related protein 5, mitochondrial [Tribolium castaneum] 705677805 XM_010119203.1 44 1.11424e-11 PREDICTED: Chlamydotis macqueenii glutaredoxin 5 (GLRX5), partial mRNA K07390 grxD, GLRX5 monothiol glutaredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K07390 Q86SX6 461 6.9e-45 Glutaredoxin-related protein 5, mitochondrial OS=Homo sapiens GN=GLRX5 PE=1 SV=2 PF00462 Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG0911 Glutaredoxin-related protein Cluster-8309.27881 BF_2 436.00 10.59 2009 780074942 XP_011672046.1 260 9.3e-20 PREDICTED: ankyrin repeat domain-containing protein 17-like [Strongylocentrotus purpuratus] -- -- -- -- -- K09454 GABPB GA-binding protein transcription factor, beta http://www.genome.jp/dbget-bin/www_bget?ko:K09454 Q4UMH6 215 6.3e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27882 BF_2 43.00 11.58 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27884 BF_2 76.19 5.35 883 91082383 XP_968748.1 728 2.2e-74 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 469 9.8e-46 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF10766//PF00664 Multidrug efflux pump-associated protein AcrZ//ABC transporter transmembrane region GO:0006810//GO:0006855//GO:0055085//GO:0015893 transport//drug transmembrane transport//transmembrane transport//drug transport GO:0015238//GO:0005524//GO:0017111//GO:0042626 drug transmembrane transporter activity//ATP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.27885 BF_2 52.40 0.88 2782 91082383 XP_968748.1 1577 2.5e-172 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1057 2.0e-113 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF10598//PF00437//PF00004//PF13304//PF00664//PF00931//PF02367//PF03193//PF00005 RNA recognition motif of the spliceosomal PrP8//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085//GO:0002949 transport//transmembrane transport//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0043531//GO:0005524//GO:0003723//GO:0017111//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//RNA binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.27888 BF_2 294.87 16.04 1056 546676952 ERL87876.1 1259 7.0e-136 hypothetical protein D910_05264 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 629 3.3e-64 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01700//PF01073//PF01370 Orbivirus VP3 (T2) protein//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008210 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//estrogen metabolic process GO:0003854//GO:0003824//GO:0050662//GO:0016616//GO:0005198 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural molecule activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.27891 BF_2 1224.47 26.99 2185 859132801 AKO63316.1 1777 1.3e-195 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 1402 1.6e-153 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF00108//PF02803 Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.27892 BF_2 1.00 6.28 246 340385288 XP_003391142.1 196 3.0e-13 PREDICTED: ankyrin-1-like [Amphimedon queenslandica] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 168 2.2e-11 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.27893 BF_2 74.90 0.79 4240 642927970 XP_972030.2 2630 3.0e-294 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 255552749 XM_002517372.1 35 6.73511e-06 Ricinus communis mannosidase alpha class 2a, putative, mRNA K01231 MAN2 alpha-mannosidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01231 Q24451 1715 1.5e-189 Alpha-mannosidase 2 OS=Drosophila melanogaster GN=alpha-Man-II PE=1 SV=2 PF09261//PF01074//PF08053//PF07748 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Tryptophanase operon leader peptide//Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975//GO:0031556//GO:0031554 mannose metabolic process//carbohydrate metabolic process//transcriptional attenuation by ribosome//regulation of DNA-templated transcription, termination GO:0008270//GO:0004559//GO:0015923//GO:0004553 zinc ion binding//alpha-mannosidase activity//mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.27897 BF_2 116.46 3.82 1561 189242434 XP_967120.2 498 1.8e-47 PREDICTED: thioredoxin domain-containing protein 17-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DBT3 289 1.3e-24 Thioredoxin domain-containing protein 17 OS=Danio rerio GN=txndc17 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3425 Uncharacterized conserved protein Cluster-8309.27898 BF_2 80.22 1.65 2316 189240973 XP_967534.2 2131 1.2e-236 PREDICTED: TNF receptor-associated factor 4 isoform X1 [Tribolium castaneum] 817199300 XM_012419904.1 272 6.53686e-138 PREDICTED: Orussus abietinus TNF receptor-associated factor 4 (LOC105696990), transcript variant X2, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 1116 2.4e-120 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF02176//PF00096//PF15965//PF03145 TRAF-type zinc finger//Zinc finger, C2H2 type//TRAF-like zinc-finger//Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG0297 TNF receptor-associated factor Cluster-8309.27900 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27901 BF_2 46.38 1.49 1591 91092778 XP_973837.1 342 2.3e-29 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.27903 BF_2 1575.41 9.50 7224 546685128 ERL94655.1 4086 0.0e+00 hypothetical protein D910_11930, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24298 2999 0.0e+00 DE-cadherin OS=Drosophila melanogaster GN=shg PE=1 SV=2 PF00028//PF01049//PF00008 Cadherin domain//Cadherin cytoplasmic region//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.27905 BF_2 13.77 0.36 1900 270005690 EFA02138.1 363 1.0e-31 hypothetical protein TcasGA2_TC007788 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 209 3.0e-15 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 PF00895//PF02310 ATP synthase protein 8//B12 binding domain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0031419//GO:0015078//GO:0046872 cobalamin binding//hydrogen ion transmembrane transporter activity//metal ion binding GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2882 p-Nitrophenyl phosphatase Cluster-8309.27908 BF_2 203.22 0.91 9637 91086935 XP_972534.1 3774 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2369 5.1e-265 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13958//PF14719//PF00664//PF13304//PF01926//PF00437//PF00005//PF05209//PF03193//PF02724//PF00640//PF00931 Toxin ToxN, type III toxin-antitoxin system//Phosphotyrosine interaction domain (PTB/PID)//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein//ABC transporter//Septum formation inhibitor MinC, N-terminal domain//Protein of unknown function, DUF258//CDC45-like protein//Phosphotyrosine interaction domain (PTB/PID)//NB-ARC domain GO:0051252//GO:0009987//GO:0051302//GO:0055085//GO:0006270//GO:0006810 regulation of RNA metabolic process//cellular process//regulation of cell division//transmembrane transport//DNA replication initiation//transport GO:0000166//GO:0016887//GO:0042626//GO:0005524//GO:0003924//GO:0004521//GO:0005525//GO:0003723//GO:0043531//GO:0005515 nucleotide binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//endoribonuclease activity//GTP binding//RNA binding//ADP binding//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.27909 BF_2 74.08 1.18 2906 642927029 XP_008195110.1 1013 6.5e-107 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AY04 189 9.4e-13 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Rattus norvegicus PE=2 SV=1 PF07961//PF00170//PF12884 MBA1-like protein//bZIP transcription factor//Transducer of regulated CREB activity, N terminus GO:0051289//GO:0032979//GO:0006355 protein homotetramerization//protein insertion into mitochondrial membrane from inner side//regulation of transcription, DNA-templated GO:0008140//GO:0043565//GO:0003700 cAMP response element binding protein binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005743//GO:0005667 mitochondrial inner membrane//transcription factor complex -- -- Cluster-8309.2791 BF_2 28.42 0.88 1644 321465971 EFX76969.1 1014 2.8e-107 hypothetical protein DAPPUDRAFT_321849 [Daphnia pulex] -- -- -- -- -- -- -- -- -- O02485 764 1.1e-79 Uncharacterized protein ZK1073.1 OS=Caenorhabditis elegans GN=ZK1073.1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.27911 BF_2 511.70 4.85 4697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27915 BF_2 141.70 1.29 4865 642912121 XP_008200815.1 1300 5.7e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1R3 469 5.4e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF01134//PF01852//PF07664//PF00070//PF00899//PF01266//PF00965//PF01593//PF12831//PF01494//PF07992//PF09452 Glucose inhibited division protein A//START domain//Ferrous iron transport protein B C terminus//Pyridine nucleotide-disulphide oxidoreductase//ThiF family//FAD dependent oxidoreductase//Tissue inhibitor of metalloproteinase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//ESCRT-I subunit Mvb12 GO:0032509//GO:0015684//GO:0008033//GO:0055114 endosome transport via multivesicular body sorting pathway//ferrous iron transport//tRNA processing//oxidation-reduction process GO:0008191//GO:0071949//GO:0043130//GO:0008289//GO:0015093//GO:0016491//GO:0050660//GO:0008641 metalloendopeptidase inhibitor activity//FAD binding//ubiquitin binding//lipid binding//ferrous iron transmembrane transporter activity//oxidoreductase activity//flavin adenine dinucleotide binding//small protein activating enzyme activity GO:0016021//GO:0000813 integral component of membrane//ESCRT I complex -- -- Cluster-8309.27916 BF_2 35.30 0.64 2582 642912121 XP_008200815.1 1300 3.0e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 414 6.8e-39 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01266//PF01134//PF00899//PF07664//PF00070//PF01494//PF07992//PF02740//PF01593//PF12831 FAD dependent oxidoreductase//Glucose inhibited division protein A//ThiF family//Ferrous iron transport protein B C terminus//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Colipase, C-terminal domain//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase GO:0016042//GO:0008033//GO:0015684//GO:0055114//GO:0007586 lipid catabolic process//tRNA processing//ferrous iron transport//oxidation-reduction process//digestion GO:0050660//GO:0008047//GO:0008641//GO:0071949//GO:0015093//GO:0016491 flavin adenine dinucleotide binding//enzyme activator activity//small protein activating enzyme activity//FAD binding//ferrous iron transmembrane transporter activity//oxidoreductase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.27917 BF_2 3.00 0.32 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27918 BF_2 975.00 15.42 2933 91077792 XP_969461.1 2655 2.6e-297 PREDICTED: E3 UFM1-protein ligase 1 homolog [Tribolium castaneum]>gi|270001494|gb|EEZ97941.1| hypothetical protein TcasGA2_TC000331 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IG18 1620 1.1e-178 E3 UFM1-protein ligase 1 homolog OS=Aedes aegypti GN=AAEL003536 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2235 Uncharacterized conserved protein Cluster-8309.27920 BF_2 2.00 0.42 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27923 BF_2 30.16 0.81 1852 91079957 XP_969398.1 796 6.0e-82 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27924 BF_2 28.37 0.77 1831 91079957 XP_969398.1 796 5.9e-82 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27926 BF_2 198.51 0.68 12521 642937614 XP_008199122.1 11693 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 491 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 3271 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF07236//PF02898//PF00569//PF06701 Phytoreovirus S7 protein//Nitric oxide synthase, oxygenase domain//Zinc finger, ZZ type//Mib_herc2 GO:0055114//GO:0016567//GO:0006809 oxidation-reduction process//protein ubiquitination//nitric oxide biosynthetic process GO:0046872//GO:0008270//GO:0004842//GO:0004517 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//nitric-oxide synthase activity GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.27928 BF_2 35.24 1.34 1387 91079768 XP_966889.1 455 1.6e-42 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 P15428 253 1.7e-20 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Homo sapiens GN=HPGD PE=1 SV=1 PF00899//PF01370//PF01073//PF13912//PF00106 ThiF family//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//C2H2-type zinc finger//short chain dehydrogenase GO:0008152//GO:0008210//GO:0008207//GO:0055114//GO:0006694//GO:0008209 metabolic process//estrogen metabolic process//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0016616//GO:0016491//GO:0000166//GO:0046872//GO:0008641 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//nucleotide binding//metal ion binding//small protein activating enzyme activity -- -- -- -- Cluster-8309.27930 BF_2 32.56 0.93 1745 642920133 XP_975457.2 643 3.1e-64 PREDICTED: NEDD4 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NV92 274 7.9e-23 NEDD4 family-interacting protein 2 OS=Homo sapiens GN=NDFIP2 PE=1 SV=2 PF10176//PF04479 Protein of unknown function (DUF2370)//RTA1 like protein GO:0006950//GO:0030001//GO:0007034 response to stress//metal ion transport//vacuolar transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.27931 BF_2 480.73 23.25 1152 642920133 XP_975457.2 825 1.6e-85 PREDICTED: NEDD4 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91ZP6 287 1.6e-24 NEDD4 family-interacting protein 2 (Fragment) OS=Mus musculus GN=Ndfip2 PE=1 SV=2 PF10176 Protein of unknown function (DUF2370) GO:0030001//GO:0007034 metal ion transport//vacuolar transport -- -- -- -- -- -- Cluster-8309.27934 BF_2 1578.21 61.25 1365 91087659 XP_973571.1 948 1.1e-99 PREDICTED: proteasome subunit beta type-6 [Tribolium castaneum]>gi|270009417|gb|EFA05865.1| hypothetical protein TcasGA2_TC008665 [Tribolium castaneum] -- -- -- -- -- K02738 PSMB6 20S proteasome subunit beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02738 Q3MHN0 713 7.7e-74 Proteasome subunit beta type-6 OS=Bos taurus GN=PSMB6 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839//GO:0005634//GO:0005737 proteasome core complex//nucleus//cytoplasm KOG0174 20S proteasome, regulatory subunit beta type PSMB6/PSMB9/PRE3 Cluster-8309.27936 BF_2 4.70 2.48 363 642914190 XP_008201582.1 181 2.4e-11 PREDICTED: uncharacterized protein LOC661670 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27937 BF_2 57.00 6.45 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O81338 138 1.7e-07 Antimicrobial peptide 1 OS=Mesembryanthemum crystallinum PE=3 SV=1 PF08116 PhTx neurotoxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.27939 BF_2 315.00 8.95 1760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27943 BF_2 55.00 2.56 1185 642937675 XP_008198897.1 227 3.7e-16 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC655743 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus -- -- Cluster-8309.27945 BF_2 94.62 3.69 1361 91087735 XP_974721.1 297 3.2e-24 PREDICTED: synaptosomal-associated protein 25 isoform X3 [Tribolium castaneum] 827536800 XM_012689330.1 106 7.22236e-46 PREDICTED: Bombyx mori synaptosomal-associated protein 25 (LOC101739206), transcript variant X1, mRNA K08508 SNAP23 synaptosomal-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K08508 P36975 253 1.7e-20 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 PF05739 SNARE domain -- -- GO:0005515 protein binding -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.27946 BF_2 189.58 2.24 3824 642924301 XP_008194238.1 2952 0.0e+00 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924303|ref|XP_008194239.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924305|ref|XP_008194240.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 2140 7.3e-239 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF12831//PF13202//PF07992//PF00036//PF02976//PF01134//PF12632//PF13499//PF01266//PF13833//PF13405 FAD dependent oxidoreductase//EF hand//Pyridine nucleotide-disulphide oxidoreductase//EF hand//DNA mismatch repair enzyme MutH//Glucose inhibited division protein A//Mysoin-binding motif of peroxisomes//EF-hand domain pair//FAD dependent oxidoreductase//EF-hand domain pair//EF-hand domain GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0016491//GO:0004519//GO:0003677//GO:0005509//GO:0050660//GO:0017022 oxidoreductase activity//endonuclease activity//DNA binding//calcium ion binding//flavin adenine dinucleotide binding//myosin binding GO:0016459 myosin complex KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.27947 BF_2 291.17 7.78 1853 478261514 ENN80859.1 712 3.3e-72 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 P13582 486 2.2e-47 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.27948 BF_2 676.00 21.51 1602 91085959 XP_971351.1 940 1.0e-98 PREDICTED: RNA-binding protein pno1 [Tribolium castaneum]>gi|270010173|gb|EFA06621.1| hypothetical protein TcasGA2_TC009539 [Tribolium castaneum] 754410228 XM_011276050.1 55 1.91403e-17 Wickerhamomyces ciferrii Pre-rRNA-processing protein partial mRNA K11884 PNO1, DIM2 RNA-binding protein PNO1 http://www.genome.jp/dbget-bin/www_bget?ko:K11884 Q29IG6 762 1.9e-79 RNA-binding protein pno1 OS=Drosophila pseudoobscura pseudoobscura GN=l(1)G0004 PE=3 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG3273 Predicted RNA-binding protein Pno1p interacting with Nob1p and involved in 26S proteasome assembly Cluster-8309.27949 BF_2 33.69 0.74 2191 642922855 XP_008200424.1 1554 9.1e-170 PREDICTED: mRNA cap guanine-N7 methyltransferase [Tribolium castaneum] -- -- -- -- -- K00565 RNMT mRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00565 Q9VJQ4 976 3.9e-104 mRNA cap guanine-N7 methyltransferase OS=Drosophila melanogaster GN=l(2)35Bd PE=1 SV=2 PF09807//PF08241 Elongation complex protein 6//Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity GO:0033588 Elongator holoenzyme complex KOG1975 mRNA cap methyltransferase Cluster-8309.27950 BF_2 367.31 8.99 1997 642922855 XP_008200424.1 1554 8.2e-170 PREDICTED: mRNA cap guanine-N7 methyltransferase [Tribolium castaneum] -- -- -- -- -- K00565 RNMT mRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00565 Q9VJQ4 976 3.6e-104 mRNA cap guanine-N7 methyltransferase OS=Drosophila melanogaster GN=l(2)35Bd PE=1 SV=2 PF09807//PF08241 Elongation complex protein 6//Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity GO:0033588 Elongator holoenzyme complex KOG1975 mRNA cap methyltransferase Cluster-8309.27952 BF_2 196.31 8.15 1295 91094189 XP_971060.1 879 1.0e-91 PREDICTED: G protein pathway suppressor 2 isoform X1 [Tribolium castaneum]>gi|270010855|gb|EFA07303.1| hypothetical protein TcasGA2_TC015893 [Tribolium castaneum] -- -- -- -- -- K15307 GPS2 G protein pathway suppressor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15307 Q13227 149 1.8e-08 G protein pathway suppressor 2 OS=Homo sapiens GN=GPS2 PE=1 SV=3 PF15048 Organic solute transporter subunit beta protein GO:0015721//GO:0006810 bile acid and bile salt transport//transport GO:0046982//GO:0005215 protein heterodimerization activity//transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.27956 BF_2 351.86 6.52 2544 546672885 ERL84608.1 1321 1.1e-142 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 947 1.1e-100 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00067//PF15681//PF00108//PF08545 Cytochrome P450//Lymphocyte activation family X//Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0042967//GO:0008152//GO:0006633//GO:0055114//GO:0006955//GO:0051249 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process//oxidation-reduction process//immune response//regulation of lymphocyte activation GO:0004315//GO:0016705//GO:0016747//GO:0005506//GO:0020037 3-oxoacyl-[acyl-carrier-protein] synthase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//transferase activity, transferring acyl groups other than amino-acyl groups//iron ion binding//heme binding GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.27958 BF_2 200.12 13.42 911 478256130 ENN76329.1 942 3.5e-99 hypothetical protein YQE_07292, partial [Dendroctonus ponderosae]>gi|546675872|gb|ERL86977.1| hypothetical protein D910_04380 [Dendroctonus ponderosae] -- -- -- -- -- K07556 ATPeAF2, ATPAF2, ATP12 ATP synthase mitochondrial F1 complex assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07556 Q1LZ96 580 1.4e-58 ATP synthase mitochondrial F1 complex assembly factor 2 OS=Bos taurus GN=ATPAF2 PE=2 SV=1 PF07542 ATP12 chaperone protein GO:0043461 proton-transporting ATP synthase complex assembly -- -- -- -- KOG3015 F1-ATP synthase assembly protein Cluster-8309.27960 BF_2 237.62 9.02 1389 91081511 XP_974643.1 958 7.4e-101 PREDICTED: vesicle-associated membrane protein 7 [Tribolium castaneum]>gi|270006153|gb|EFA02601.1| hypothetical protein TcasGA2_TC008320 [Tribolium castaneum] -- -- -- -- -- K08515 VAMP7 vesicle-associated membrane protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08515 P70280 704 8.6e-73 Vesicle-associated membrane protein 7 OS=Mus musculus GN=Vamp7 PE=1 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0859 Synaptobrevin/VAMP-like protein Cluster-8309.27961 BF_2 58.08 0.67 3934 91077466 XP_968191.1 636 4.6e-63 PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|642914015|ref|XP_008201511.1| PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|270002138|gb|EEZ98585.1| hypothetical protein TcasGA2_TC001099 [Tribolium castaneum] -- -- -- -- -- K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 Q5EB97 167 4.5e-10 Zinc finger CCHC domain-containing protein 10 OS=Rattus norvegicus GN=Zcchc10 PE=2 SV=2 PF02190//PF09726//PF04889//PF00098 ATP-dependent protease La (LON) substrate-binding domain//Transmembrane protein//Cwf15/Cwc15 cell cycle control protein//Zinc knuckle GO:0000398//GO:0006510//GO:0006508 mRNA splicing, via spliceosome//obsolete ATP-dependent proteolysis//proteolysis GO:0003676//GO:0004176//GO:0008270 nucleic acid binding//ATP-dependent peptidase activity//zinc ion binding GO:0005681//GO:0016021 spliceosomal complex//integral component of membrane KOG3116 Predicted C3H1-type Zn-finger protein Cluster-8309.27963 BF_2 90.10 2.79 1640 283046732 NP_001164313.1 1426 4.7e-155 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 1.7e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.27966 BF_2 39.21 0.58 3114 642917502 XP_008191229.1 1994 1.2e-220 PREDICTED: uncharacterized protein LOC657403 [Tribolium castaneum] 642917501 XM_008193007.1 460 0 PREDICTED: Tribolium castaneum uncharacterized LOC657403 (LOC657403), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27967 BF_2 421.00 36.32 772 91089671 XP_974390.1 493 3.4e-47 PREDICTED: protein lethal(2)essential for life [Tribolium castaneum]>gi|270012628|gb|EFA09076.1| hypothetical protein TcasGA2_TC006793 [Tribolium castaneum] 817189789 XM_012414812.1 41 5.46549e-10 PREDICTED: Orussus abietinus protein lethal(2)essential for life-like (LOC105694292), mRNA K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 280 7.0e-24 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.27968 BF_2 51.73 0.46 5013 270012482 EFA08930.1 2066 8.8e-229 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 992 1.3e-105 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.27970 BF_2 14.07 0.35 1957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02121 Phosphatidylinositol transfer protein GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.27971 BF_2 745.44 19.60 1878 751799211 XP_011209556.1 688 2.0e-69 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 4.7e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF16367//PF00076//PF06839//PF13606//PF00887//PF00023 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//GRF zinc finger//Ankyrin repeat//Acyl CoA binding protein//Ankyrin repeat -- -- GO:0005515//GO:0003676//GO:0008270//GO:0000062 protein binding//nucleic acid binding//zinc ion binding//fatty-acyl-CoA binding -- -- -- -- Cluster-8309.27973 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27976 BF_2 39.72 1.87 1175 -- -- -- -- -- 462299627 APGK01051253.1 52 6.47851e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27980 BF_2 120.56 1.18 4552 727098876 AIY54294.1 1897 3.2e-209 actin 2 [Colaphellus bowringi] 605059338 KJ187399.1 270 1.67362e-136 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1829 1.0e-202 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.27981 BF_2 194.56 1.28 6649 478258659 ENN78709.1 2012 2.1e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.27608e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 770 9.2e-80 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07500//PF00628//PF07533//PF06427 Transcription factor S-II (TFIIS), central domain//PHD-finger//BRK domain//UDP-glucose:Glycoprotein Glucosyltransferase GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0016817//GO:0003980//GO:0005515 hydrolase activity, acting on acid anhydrides//UDP-glucose:glycoprotein glucosyltransferase activity//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.27983 BF_2 153.06 1.82 3811 642933538 XP_008197461.1 1923 2.6e-212 PREDICTED: tyrosine-protein phosphatase non-receptor type 4 [Tribolium castaneum]>gi|270011334|gb|EFA07782.1| hypothetical protein TcasGA2_TC005339 [Tribolium castaneum] 817186761 XM_012432473.1 151 1.98406e-70 PREDICTED: Orussus abietinus tyrosine-protein phosphatase non-receptor type 4 (LOC105703795), transcript variant X5, mRNA K18037 PTPN4, MEG tyrosine-protein phosphatase non-receptor type 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18037 Q9WU22 988 2.8e-105 Tyrosine-protein phosphatase non-receptor type 4 OS=Mus musculus GN=Ptpn4 PE=1 SV=2 PF00102//PF05891//PF00782 Protein-tyrosine phosphatase//AdoMet dependent proline di-methyltransferase//Dual specificity phosphatase, catalytic domain GO:0035335//GO:0006480//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//N-terminal protein amino acid methylation//protein dephosphorylation//tyrosine metabolic process GO:0008168//GO:0004725//GO:0008138 methyltransferase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005856 cytoskeleton KOG0792 Protein tyrosine phosphatase PTPMEG, contains FERM domain Cluster-8309.27985 BF_2 14.28 0.48 1529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27986 BF_2 59.52 0.64 4172 642916513 XP_008191072.1 1511 1.7e-164 PREDICTED: potassium voltage-gated channel protein Shaker isoform X2 [Tribolium castaneum] 642916518 XM_008192853.1 708 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X5, mRNA K05318 KCNAN potassium voltage-gated channel Shaker-related subfamily A, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05318 P08510 1356 6.5e-148 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.27987 BF_2 420.40 5.01 3796 189236660 XP_970787.2 998 4.7e-105 PREDICTED: ras-related protein Rab-30 [Tribolium castaneum] 755966246 XM_011307137.1 176 2.50266e-84 PREDICTED: Fopius arisanus ras-related protein Rab-30 (LOC105267941), mRNA K07917 RAB30 Ras-related protein Rab-30 http://www.genome.jp/dbget-bin/www_bget?ko:K07917 Q17QB7 701 5.3e-72 Ras-related protein Rab-30 OS=Bos taurus GN=RAB30 PE=2 SV=1 PF04670//PF00071//PF02367//PF03193//PF00176//PF00025//PF02421//PF00004//PF01926//PF08477//PF07728 Gtr1/RagA G protein conserved region//Ras family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//SNF2 family N-terminal domain//ADP-ribosylation factor family//Ferrous iron transport protein B//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily) GO:0002949//GO:0007264//GO:0015684 tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0016887//GO:0015093//GO:0005524//GO:0003924 GTP binding//ATPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0095 GTPase Rab30, small G protein superfamily Cluster-8309.27991 BF_2 781.74 14.54 2536 642929814 XP_008195987.1 1125 5.8e-120 PREDICTED: E3 ubiquitin-protein ligase Topors-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10631 TOPORS E3 ubiquitin-protein ligase Topors http://www.genome.jp/dbget-bin/www_bget?ko:K10631 Q9V8P9 487 2.3e-47 E3 ubiquitin-protein ligase Topors OS=Drosophila melanogaster GN=Topors PE=1 SV=1 PF01480//PF13639//PF16685//PF12678//PF14634//PF12861//PF00097 PWI domain//Ring finger domain//zinc RING finger of MSL2//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger) GO:0006397//GO:0016567 mRNA processing//protein ubiquitination GO:0008270//GO:0046872//GO:0061630//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG4430 Topoisomerase I-binding arginine-serine-rich protein Cluster-8309.27994 BF_2 309.75 1.69 7955 642926648 XP_970736.2 988 1.4e-103 PREDICTED: elongator complex protein 1 [Tribolium castaneum] 642911902 XM_008200793.1 91 9.39577e-37 PREDICTED: Tribolium castaneum heat shock factor protein-like (LOC103314511), transcript variant X4, mRNA K09418 HSFN heat shock transcription factor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09418 Q9VGK7 484 1.6e-46 Putative elongator complex protein 1 OS=Drosophila melanogaster GN=Elp1 PE=1 SV=2 PF00447//PF00637 HSF-type DNA-binding//Region in Clathrin and VPS GO:0006355//GO:0006886//GO:0016192 regulation of transcription, DNA-templated//intracellular protein transport//vesicle-mediated transport GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0627 Heat shock transcription factor Cluster-8309.27995 BF_2 6.00 52.08 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27996 BF_2 62.00 29.67 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.27999 BF_2 232.00 2.90 3632 642928127 XP_970826.2 344 3.0e-29 PREDICTED: uncharacterized protein LOC659425 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03598 CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0006084//GO:0015947 acetyl-CoA metabolic process//methane metabolic process GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity -- -- -- -- Cluster-8309.280 BF_2 6.00 0.50 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28000 BF_2 93.00 3.97 1268 91079036 XP_974974.1 1426 3.6e-155 PREDICTED: mediator of RNA polymerase II transcription subunit 27 [Tribolium castaneum]>gi|270003666|gb|EFA00114.1| hypothetical protein TcasGA2_TC002930 [Tribolium castaneum] -- -- -- -- -- K15170 MED27 mediator of RNA polymerase II transcription subunit 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15170 Q7QCJ9 854 3.2e-90 Mediator of RNA polymerase II transcription subunit 27 OS=Anopheles gambiae GN=MED27 PE=3 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28002 BF_2 2.00 0.46 468 260815961 XP_002602741.1 139 2.3e-06 hypothetical protein BRAFLDRAFT_233840 [Branchiostoma floridae]>gi|229288052|gb|EEN58753.1| hypothetical protein BRAFLDRAFT_233840, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04988//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.28003 BF_2 33.10 1.07 1587 546673009 ERL84695.1 199 8.7e-13 hypothetical protein D910_02121 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- C3XVM1 144 8.5e-08 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Branchiostoma floridae GN=BRAFLDRAFT_270748 PE=3 SV=1 PF02686 Glu-tRNAGln amidotransferase C subunit GO:0006450 regulation of translational fidelity -- -- -- -- -- -- Cluster-8309.28006 BF_2 165.03 1.55 4738 642931654 XP_008196673.1 2461 1.3e-274 PREDICTED: rap1 GTPase-activating protein 1 isoform X1 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.55181e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.2e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF02188//PF07836//PF02145//PF13851 GoLoco motif//DmpG-like communication domain//Rap/ran-GAP//Growth-arrest specific micro-tubule binding GO:0048870//GO:0051056//GO:0019439 cell motility//regulation of small GTPase mediated signal transduction//aromatic compound catabolic process GO:0016833//GO:0005096//GO:0030695 oxo-acid-lyase activity//GTPase activator activity//GTPase regulator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.28008 BF_2 633.62 77.99 627 478254316 ENN74570.1 289 1.3e-23 hypothetical protein YQE_08892, partial [Dendroctonus ponderosae]>gi|546674045|gb|ERL85533.1| hypothetical protein D910_02952 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2801 BF_2 24.11 0.36 3105 270004597 EFA01045.1 342 4.4e-29 hypothetical protein TcasGA2_TC003961 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28013 BF_2 874.14 6.23 6152 642936704 XP_008198546.1 1663 5.8e-182 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 158 7.9e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF13895//PF02793//PF00008 Immunoglobulin domain//Hormone receptor domain//EGF-like domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.28014 BF_2 24.00 1.28 1072 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02118 Srg family chemoreceptor GO:0007165//GO:0007606 signal transduction//sensory perception of chemical stimulus GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.28016 BF_2 539.60 10.68 2401 642916627 XP_008191963.1 1621 1.7e-177 PREDICTED: GPI mannosyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K05284 PIGM phosphatidylinositol glycan, class M http://www.genome.jp/dbget-bin/www_bget?ko:K05284 Q7S4Z3 538 2.6e-53 GPI mannosyltransferase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gim-1 PE=3 SV=1 PF16622//PF05051//PF06728//PF05007 zinc-finger C2H2-type//Cytochrome C oxidase copper chaperone (COX17)//GPI transamidase subunit PIG-U//Mannosyltransferase (PIG-M) GO:0006825//GO:0006506 copper ion transport//GPI anchor biosynthetic process GO:0005507//GO:0016531//GO:0016758//GO:0046872 copper ion binding//copper chaperone activity//transferase activity, transferring hexosyl groups//metal ion binding GO:0016021//GO:0005758 integral component of membrane//mitochondrial intermembrane space KOG3893 Mannosyltransferase Cluster-8309.28017 BF_2 215.40 4.44 2317 642916627 XP_008191963.1 1621 1.6e-177 PREDICTED: GPI mannosyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K05284 PIGM phosphatidylinositol glycan, class M http://www.genome.jp/dbget-bin/www_bget?ko:K05284 Q7S4Z3 538 2.6e-53 GPI mannosyltransferase 1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gim-1 PE=3 SV=1 PF06728//PF05051//PF16622//PF05007 GPI transamidase subunit PIG-U//Cytochrome C oxidase copper chaperone (COX17)//zinc-finger C2H2-type//Mannosyltransferase (PIG-M) GO:0006825//GO:0006506 copper ion transport//GPI anchor biosynthetic process GO:0005507//GO:0016531//GO:0016758//GO:0046872 copper ion binding//copper chaperone activity//transferase activity, transferring hexosyl groups//metal ion binding GO:0016021//GO:0005758 integral component of membrane//mitochondrial intermembrane space KOG3893 Mannosyltransferase Cluster-8309.28019 BF_2 690.78 9.62 3292 270008994 EFA05442.1 170 4.1e-09 hypothetical protein TcasGA2_TC015621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF08038 Ligand-gated ion channel//TOM7 family GO:0007165//GO:0007268//GO:0030150//GO:0006811 signal transduction//synaptic transmission//protein import into mitochondrial matrix//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016020//GO:0005742 membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.28020 BF_2 79.53 0.77 4580 189238821 XP_968538.2 715 3.7e-72 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|642927448|ref|XP_008195277.1| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|270010156|gb|EFA06604.1| hypothetical protein TcasGA2_TC009519 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 360 2.2e-32 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF13184//PF13014//PF00013//PF07650 NusA-like KH domain//KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.28021 BF_2 38.51 1.21 1617 546678918 ERL89456.1 328 9.7e-28 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 97 8.6779e-41 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q7KQZ4 197 6.2e-14 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28022 BF_2 139.39 6.62 1168 642929008 XP_008195652.1 996 2.4e-105 PREDICTED: mediator of RNA polymerase II transcription subunit 8 [Tribolium castaneum]>gi|270010446|gb|EFA06894.1| hypothetical protein TcasGA2_TC009839 [Tribolium castaneum] -- -- -- -- -- K15129 MED8 mediator of RNA polymerase II transcription subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K15129 Q16RR7 652 7.8e-67 Mediator of RNA polymerase II transcription subunit 8 OS=Aedes aegypti GN=MED8 PE=3 SV=1 PF10232//PF16969 Mediator of RNA polymerase II transcription complex subunit 8//RNA-binding signal recognition particle 68 GO:0006614//GO:0006357 SRP-dependent cotranslational protein targeting to membrane//regulation of transcription from RNA polymerase II promoter GO:0030942//GO:0001104//GO:0008312//GO:0005047 endoplasmic reticulum signal peptide binding//RNA polymerase II transcription cofactor activity//7S RNA binding//signal recognition particle binding GO:0016592//GO:0005786 mediator complex//signal recognition particle, endoplasmic reticulum targeting KOG3583 Uncharacterized conserved protein Cluster-8309.28023 BF_2 16.59 1.06 942 91085093 XP_967751.1 409 2.3e-37 PREDICTED: uridine diphosphate glucose pyrophosphatase [Tribolium castaneum]>gi|270008500|gb|EFA04948.1| hypothetical protein TcasGA2_TC015015 [Tribolium castaneum] -- -- -- -- -- K08077 NUDT14 UDP-sugar diphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K08077 Q05B60 139 1.9e-07 Uridine diphosphate glucose pyrophosphatase OS=Bos taurus GN=NUDT14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4432 Uncharacterized NUDIX family hydrolase Cluster-8309.28027 BF_2 8.00 0.78 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28029 BF_2 93.66 2.48 1870 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07726 ATPase family associated with various cellular activities (AAA) -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- -- -- Cluster-8309.28030 BF_2 357.51 6.57 2563 478249755 ENN70263.1 495 6.7e-47 hypothetical protein YQE_13046, partial [Dendroctonus ponderosae] -- -- -- -- -- K06695 PSMC3IP 26S proteasome regulatory subunit, ATPase 3, interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K06695 Q63ZL2 310 7.7e-27 Homologous-pairing protein 2 homolog OS=Xenopus laevis GN=psmc3ip PE=2 SV=1 PF03647//PF03965//PF06156//PF08702//PF02601//PF10186 Transmembrane proteins 14C//Penicillinase repressor//Protein of unknown function (DUF972)//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006308//GO:0010508//GO:0030168//GO:0006260//GO:0045892//GO:0051258//GO:0007165 DNA catabolic process//positive regulation of autophagy//platelet activation//DNA replication//negative regulation of transcription, DNA-templated//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0008855//GO:0003677 receptor binding//protein binding, bridging//exodeoxyribonuclease VII activity//DNA binding GO:0005577//GO:0016020//GO:0009318 fibrinogen complex//membrane//exodeoxyribonuclease VII complex KOG4603 TBP-1 interacting protein Cluster-8309.28031 BF_2 730.00 21.22 1726 478250897 ENN71383.1 1324 3.3e-143 hypothetical protein YQE_11930, partial [Dendroctonus ponderosae]>gi|546671861|gb|ERL83988.1| hypothetical protein D910_01304 [Dendroctonus ponderosae]>gi|546671866|gb|ERL83991.1| hypothetical protein D910_01307 [Dendroctonus ponderosae]>gi|546678247|gb|ERL88919.1| hypothetical protein D910_06297 [Dendroctonus ponderosae] 751451367 XM_011181705.1 63 7.37645e-22 PREDICTED: Bactrocera cucurbitae partitioning defective protein 6 (LOC105210628), mRNA K06093 PARD6 partitioning defective protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06093 Q9JK83 737 1.6e-76 Partitioning defective 6 homolog beta OS=Mus musculus GN=Pard6b PE=1 SV=2 PF00595//PF13180//PF00564 PDZ domain (Also known as DHR or GLGF)//PDZ domain//PB1 domain -- -- GO:0005515 protein binding -- -- KOG3606 Cell polarity protein PAR6 Cluster-8309.28032 BF_2 134.25 1.19 4999 642931932 XP_973544.3 1710 1.7e-187 PREDICTED: structural maintenance of chromosomes protein 6 [Tribolium castaneum]>gi|270012741|gb|EFA09189.1| structural maintenance of chromosomes 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q924W5 677 4.2e-69 Structural maintenance of chromosomes protein 6 OS=Mus musculus GN=Smc6 PE=2 SV=1 PF09036//PF07926//PF00038//PF02601//PF07851//PF04632//PF13851//PF10473//PF01008//PF00015//PF04136//PF01580//PF04111//PF04048//PF04108//PF08925//PF16716//PF10186//PF04799//PF08702//PF04513//PF01146//PF06009//PF04336//PF06008//PF01544//PF06160//PF05557//PF00769//PF13304//PF00430//PF06667 Bcr-Abl oncoprotein oligomerisation domain//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Exonuclease VII, large subunit//TMPIT-like protein//Fusaric acid resistance protein family//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Initiation factor 2 subunit family//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family//FtsK/SpoIIIE family//Autophagy protein Apg6//Sec8 exocyst complex component specific domain//Autophagy protein Apg17//Domain of Unknown Function (DUF1907)//Bone marrow stromal antigen 2//Vacuolar sorting 38 and autophagy-related subunit 14//fzo-like conserved region//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Caveolin//Laminin Domain II//Protein of unknown function, DUF479//Laminin Domain I//CorA-like Mg2+ transporter protein//Septation ring formation regulator, EzrA//Mitotic checkpoint protein//Ezrin/radixin/moesin family//AAA domain, putative AbiEii toxin, Type IV TA system//ATP synthase B/B' CF(0)//Phage shock protein B GO:0006904//GO:0016310//GO:0000921//GO:0008053//GO:0044237//GO:0045995//GO:0006606//GO:0051607//GO:0030001//GO:0006308//GO:0030155//GO:0007155//GO:0051258//GO:0006468//GO:0030334//GO:0015940//GO:0006355//GO:0048870//GO:0006633//GO:0030168//GO:0055085//GO:0015992//GO:0070836//GO:0007094//GO:0015986//GO:0009069//GO:0006914//GO:0006886//GO:0006810//GO:0007165//GO:0009271//GO:0010508//GO:0015031 vesicle docking involved in exocytosis//phosphorylation//septin ring assembly//mitochondrial fusion//cellular metabolic process//regulation of embryonic development//protein import into nucleus//defense response to virus//metal ion transport//DNA catabolic process//regulation of cell adhesion//cell adhesion//protein polymerization//protein phosphorylation//regulation of cell migration//pantothenate biosynthetic process//regulation of transcription, DNA-templated//cell motility//fatty acid biosynthetic process//platelet activation//transmembrane transport//proton transport//caveola assembly//mitotic spindle assembly checkpoint//ATP synthesis coupled proton transport//serine family amino acid metabolic process//autophagy//intracellular protein transport//transport//signal transduction//phage shock//positive regulation of autophagy//protein transport GO:0008092//GO:0046873//GO:0008134//GO:0004674//GO:0008855//GO:0003677//GO:0004871//GO:0005198//GO:0005096//GO:0008770//GO:0030674//GO:0003924//GO:0045502//GO:0005524//GO:0005102//GO:0042803//GO:0000166//GO:0015078 cytoskeletal protein binding//metal ion transmembrane transporter activity//transcription factor binding//protein serine/threonine kinase activity//exodeoxyribonuclease VII activity//DNA binding//signal transducer activity//structural molecule activity//GTPase activator activity//[acyl-carrier-protein] phosphodiesterase activity//protein binding, bridging//GTPase activity//dynein binding//ATP binding//receptor binding//protein homodimerization activity//nucleotide binding//hydrogen ion transmembrane transporter activity GO:0030286//GO:0005882//GO:0019898//GO:0005577//GO:0009318//GO:0019031//GO:0000145//GO:0005940//GO:0016021//GO:0005737//GO:0045263//GO:0005667//GO:0019028//GO:0005634//GO:0005886//GO:0005741//GO:0016020//GO:0031514//GO:0005801 dynein complex//intermediate filament//extrinsic component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//viral envelope//exocyst//septin ring//integral component of membrane//cytoplasm//proton-transporting ATP synthase complex, coupling factor F(o)//transcription factor complex//viral capsid//nucleus//plasma membrane//mitochondrial outer membrane//membrane//motile cilium//cis-Golgi network KOG0250 DNA repair protein RAD18 (SMC family protein) Cluster-8309.28034 BF_2 31.96 0.35 4147 642910771 XP_008193403.1 2110 5.8e-234 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 1.1e-57 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF10297//PF00620 Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003677 DNA binding GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.28035 BF_2 793.54 9.22 3889 642910771 XP_008193403.1 2225 2.5e-247 PREDICTED: rho GTPase-activating protein 18 [Tribolium castaneum] -- -- -- -- -- K01816 hyi, gip hydroxypyruvate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01816 Q5T013 578 9.9e-58 Putative hydroxypyruvate isomerase OS=Homo sapiens GN=HYI PE=1 SV=2 PF00150//PF10297//PF00620 Cellulase (glycosyl hydrolase family 5)//Minimal binding motif of Hap4 for binding to Hap2/3/5//RhoGAP domain GO:0007165//GO:0006355//GO:0005975 signal transduction//regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0003677//GO:0004553 DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005634 nucleus KOG4518 Hydroxypyruvate isomerase Cluster-8309.28038 BF_2 313.00 22.47 870 91087931 XP_971703.1 683 3.6e-69 PREDICTED: suppressor of G2 allele of SKP1 homolog [Tribolium castaneum]>gi|270012029|gb|EFA08477.1| hypothetical protein TcasGA2_TC006127 [Tribolium castaneum] -- -- -- -- -- K12795 SUGT1, SGT1 suppressor of G2 allele of SKP1 http://www.genome.jp/dbget-bin/www_bget?ko:K12795 B0BN85 468 1.3e-45 Protein SGT1 homolog OS=Rattus norvegicus GN=Sugt1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1309 Suppressor of G2 allele of skp1 Cluster-8309.28040 BF_2 566.98 12.31 2214 478251133 ENN71609.1 2456 2.3e-274 hypothetical protein YQE_11708, partial [Dendroctonus ponderosae]>gi|546680326|gb|ERL90612.1| hypothetical protein D910_07959 [Dendroctonus ponderosae] 769832105 XM_011642084.1 121 5.44426e-54 PREDICTED: Pogonomyrmex barbatus SUMO-activating enzyme subunit 2 (LOC105429240), mRNA K10685 UBLE1B, SAE2, UBA2 ubiquitin-like 1-activating enzyme E1 B http://www.genome.jp/dbget-bin/www_bget?ko:K10685 Q28GH3 1625 2.2e-179 SUMO-activating enzyme subunit 2 OS=Xenopus tropicalis GN=uba2 PE=2 SV=1 PF13241//PF03435//PF07818//PF00899 Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//HCNGP-like protein//ThiF family GO:0055114//GO:0006779//GO:0019354//GO:0006355 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//regulation of transcription, DNA-templated GO:0016491//GO:0008641//GO:0043115 oxidoreductase activity//small protein activating enzyme activity//precorrin-2 dehydrogenase activity -- -- KOG2013 SMT3/SUMO-activating complex, catalytic component UBA2 Cluster-8309.28044 BF_2 286.95 29.36 696 642912103 XP_008200806.1 754 1.7e-77 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X2 [Tribolium castaneum] 268574973 XM_002642420.1 89 1.01713e-36 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 600 5.0e-61 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF16326//PF04111//PF03938//PF01517//PF00769//PF01496 ABC transporter C-terminal domain//Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Hepatitis delta virus delta antigen//Ezrin/radixin/moesin family//V-type ATPase 116kDa subunit family GO:0015992//GO:0015991//GO:0006914 proton transport//ATP hydrolysis coupled proton transport//autophagy GO:0015078//GO:0051082//GO:0003677//GO:0003723//GO:0008092 hydrogen ion transmembrane transporter activity//unfolded protein binding//DNA binding//RNA binding//cytoskeletal protein binding GO:0005737//GO:0033179//GO:0042025//GO:0019898 cytoplasm//proton-transporting V-type ATPase, V0 domain//host cell nucleus//extrinsic component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.28045 BF_2 266.76 3.33 3641 91089205 XP_966919.1 864 1.5e-89 PREDICTED: SPRY domain-containing SOCS box protein 3 [Tribolium castaneum]>gi|270012469|gb|EFA08917.1| hypothetical protein TcasGA2_TC006623 [Tribolium castaneum] -- -- -- -- -- K10345 SPSB3, SSB3 SPRY domain-containing SOCS box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10345 Q6PJ21 421 1.5e-39 SPRY domain-containing SOCS box protein 3 OS=Homo sapiens GN=SPSB3 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28049 BF_2 2.00 7.95 260 330902886 AEC48652.1 429 3.0e-40 actin, partial [Cochliopodium larifeili]>gi|330902888|gb|AEC48653.1| actin, partial [Cochliopodium larifeili]>gi|330902890|gb|AEC48654.1| actin, partial [Cochliopodium larifeili] 158292552 XM_313971.4 160 1.18577e-76 Anopheles gambiae str. PEST AGAP005095-PA (AgaP_AGAP005095) mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 Q71FK5 426 2.8e-41 Actin, cytoplasmic 1 OS=Cavia porcellus GN=ACTB PE=2 SV=1 -- -- -- -- GO:0005524 ATP binding GO:0005737//GO:0005856 cytoplasm//cytoskeleton KOG0676 Actin and related proteins Cluster-8309.28051 BF_2 16.00 0.86 1066 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28052 BF_2 13.07 0.33 1942 642919171 XP_967331.2 613 1.0e-60 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q5RFL4 454 1.2e-43 Zinc finger FYVE domain-containing protein 1 OS=Pongo abelii GN=ZFYVE1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.28053 BF_2 46.00 1.04 2146 86515330 NP_001034490.1 285 1.2e-22 pangolin [Tribolium castaneum]>gi|55832420|gb|AAV66724.1| pangolin [Tribolium castaneum] 55832417 AY800246.1 158 1.42555e-74 Tribolium castaneum pangolin gene, partial cds K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 Q9NQB0 206 7.4e-15 Transcription factor 7-like 2 OS=Homo sapiens GN=TCF7L2 PE=1 SV=2 -- -- GO:0016055 Wnt signaling pathway -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.28056 BF_2 82.25 1.04 3603 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28057 BF_2 425.12 5.32 3629 91091508 XP_969167.1 1943 1.2e-214 PREDICTED: protein LMBR1L isoform X2 [Tribolium castaneum]>gi|270000933|gb|EEZ97380.1| hypothetical protein TcasGA2_TC011205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 905 1.1e-95 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28058 BF_2 353.70 7.58 2238 642936854 XP_008197915.1 1215 1.9e-130 PREDICTED: protein LMBR1L isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UX01 579 4.3e-58 Protein LMBR1L OS=Homo sapiens GN=LMBR1L PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3722 Lipocalin-interacting membrane receptor (LIMR) Cluster-8309.28059 BF_2 41.11 0.45 4067 546676181 ERL87248.1 2281 8.4e-254 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9J0 409 4.1e-38 Mycosubtilin synthase subunit B OS=Bacillus subtilis GN=mycB PE=3 SV=1 PF00501//PF02733 AMP-binding enzyme//Dak1 domain GO:0008152//GO:0006071//GO:0046486 metabolic process//glycerol metabolic process//glycerolipid metabolic process GO:0003824//GO:0004371 catalytic activity//glycerone kinase activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.2806 BF_2 22.19 0.53 2023 270003309 EEZ99756.1 654 1.9e-65 hypothetical protein TcasGA2_TC002528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ46 362 5.7e-33 EF-hand calcium-binding domain-containing protein 2 OS=Mus musculus GN=Efcab2 PE=2 SV=1 PF03982//PF03145//PF00036//PF13405//PF13499 Diacylglycerol acyltransferase//Seven in absentia protein family//EF hand//EF-hand domain//EF-hand domain pair GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0005509//GO:0016747 calcium ion binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005634 nucleus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.28063 BF_2 235.00 17.50 849 546685100 ERL94627.1 290 1.3e-23 hypothetical protein D910_11902 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28064 BF_2 263.90 11.48 1249 270006897 EFA03345.1 533 1.3e-51 hypothetical protein TcasGA2_TC013325 [Tribolium castaneum] -- -- -- -- -- K18732 SARNP, CIP29, THO1 SAP domain-containing ribonucleoprotein http://www.genome.jp/dbget-bin/www_bget?ko:K18732 Q498U4 223 4.6e-17 SAP domain-containing ribonucleoprotein OS=Rattus norvegicus GN=Sarnp PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4259 Putative nucleic acid-binding protein Hcc-1/proliferation associated cytokine-inducible protein, contains SAP domain Cluster-8309.28066 BF_2 254.90 6.25 1992 642915192 XP_008190512.1 1457 1.5e-158 PREDICTED: protein phosphatase 1 regulatory subunit 12B-like isoform X2 [Tribolium castaneum]>gi|270003919|gb|EFA00367.1| hypothetical protein TcasGA2_TC003209 [Tribolium castaneum] 242023035 XM_002431897.1 52 1.11214e-15 Pediculus humanus corporis protein phosphatase 1 regulatory subunit 12B, putative, mRNA K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q90623 954 1.3e-101 Protein phosphatase 1 regulatory subunit 12A OS=Gallus gallus GN=PPP1R12A PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.28069 BF_2 14.82 1.14 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28070 BF_2 54.23 1.53 1771 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28071 BF_2 260.72 2.99 3931 546676985 ERL87909.1 599 8.9e-59 hypothetical protein D910_05297 [Dendroctonus ponderosae] -- -- -- -- -- K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 O61374 367 2.9e-33 Sex-lethal homolog OS=Ceratitis capitata GN=SXL PE=2 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.28073 BF_2 11.92 0.85 871 642931828 XP_971231.2 517 6.4e-50 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q8BH70 191 1.7e-13 F-box/LRR-repeat protein 4 OS=Mus musculus GN=Fbxl4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28083 BF_2 88.61 0.58 6645 642928921 XP_008195617.1 7734 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] 642928920 XM_008197395.1 1208 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4429 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF11744//PF00443//PF05395//PF01080//PF02724//PF02985 Aluminium activated malate transporter//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32//Presenilin//CDC45-like protein//HEAT repeat GO:0016579//GO:0015743//GO:0006270//GO:0007165 protein deubiquitination//malate transport//DNA replication initiation//signal transduction GO:0005515//GO:0004864//GO:0036459//GO:0004190 protein binding//protein phosphatase inhibitor activity//ubiquitinyl hydrolase activity//aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28085 BF_2 48.71 0.33 6510 270010424 EFA06872.1 8859 0.0e+00 hypothetical protein TcasGA2_TC009817 [Tribolium castaneum] 642928920 XM_008197395.1 1370 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4828 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF01080//PF02985//PF00443//PF05395 Presenilin//HEAT repeat//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32 GO:0016579//GO:0007165 protein deubiquitination//signal transduction GO:0005515//GO:0036459//GO:0004864//GO:0004190 protein binding//ubiquitinyl hydrolase activity//protein phosphatase inhibitor activity//aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28087 BF_2 28.97 0.33 3976 642928921 XP_008195617.1 5039 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1091 3.3e-117 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.28092 BF_2 729.31 13.61 2529 642923214 XP_008193658.1 1853 2.2e-204 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04360 NTRK2, TRKB neurotrophic tyrosine kinase receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04360 Q24488 711 2.4e-73 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.28093 BF_2 16.56 0.91 1050 478256643 ENN76825.1 205 1.2e-13 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N3L3 145 4.3e-08 Beta-taxilin OS=Homo sapiens GN=TXLNB PE=1 SV=3 PF09728//PF00548 Myosin-like coiled-coil protein//3C cysteine protease (picornain 3C) GO:0006508 proteolysis GO:0019905//GO:0004197 syntaxin binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.28094 BF_2 15.21 2.60 532 91088585 XP_973408.1 185 1.2e-11 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase [Tribolium castaneum]>gi|270012251|gb|EFA08699.1| hypothetical protein TcasGA2_TC006370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01591//PF00004//PF01583//PF07728//PF01926//PF00910//PF00005//PF06414 6-phosphofructo-2-kinase//ATPase family associated with various cellular activities (AAA)//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//RNA helicase//ABC transporter//Zeta toxin GO:0006013//GO:0006000//GO:0006144//GO:0000103//GO:0006003 mannose metabolic process//fructose metabolic process//purine nucleobase metabolic process//sulfate assimilation//fructose 2,6-bisphosphate metabolic process GO:0003724//GO:0005525//GO:0016301//GO:0016887//GO:0003873//GO:0004020//GO:0005524//GO:0003723//GO:0004331 RNA helicase activity//GTP binding//kinase activity//ATPase activity//6-phosphofructo-2-kinase activity//adenylylsulfate kinase activity//ATP binding//RNA binding//fructose-2,6-bisphosphate 2-phosphatase activity -- -- -- -- Cluster-8309.28095 BF_2 351.00 9.18 1887 646708450 KDR14762.1 1095 1.3e-116 60S acidic ribosomal protein P0 [Zootermopsis nevadensis] 262401274 FJ774819.1 384 0 Scylla paramamosain acidic p0 ribosomal protein mRNA, partial cds K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 P47826 1060 6.1e-114 60S acidic ribosomal protein P0 OS=Gallus gallus GN=RPLP0 PE=2 SV=1 PF00637//PF09507//PF00466//PF02932//PF06459//PF02724 Region in Clathrin and VPS//DNA polymerase subunit Cdc27//Ribosomal protein L10//Neurotransmitter-gated ion-channel transmembrane region//Ryanodine Receptor TM 4-6//CDC45-like protein GO:0042254//GO:0006811//GO:0006874//GO:0006260//GO:0006886//GO:0006270//GO:0016192//GO:0006816 ribosome biogenesis//ion transport//cellular calcium ion homeostasis//DNA replication//intracellular protein transport//DNA replication initiation//vesicle-mediated transport//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016020//GO:0005634//GO:0016021 intracellular//membrane//nucleus//integral component of membrane KOG0815 60S acidic ribosomal protein P0 Cluster-8309.28096 BF_2 10.14 1.82 520 478269658 ENN83378.1 269 2.2e-21 hypothetical protein YQE_00263, partial [Dendroctonus ponderosae] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 134 4.0e-07 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862 DDHD domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28098 BF_2 22.36 0.39 2710 642934951 XP_008195932.1 1438 3.2e-156 PREDICTED: protein MTO1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03495 gidA, mnmG, MTO1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K03495 Q4R4P6 1045 4.8e-112 Protein MTO1 homolog, mitochondrial OS=Macaca fascicularis GN=MTO1 PE=2 SV=1 PF01059//PF01134//PF12831//PF00070//PF01494//PF05834//PF07992 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Glucose inhibited division protein A//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0008033//GO:0016117//GO:0006120 oxidation-reduction process//tRNA processing//carotenoid biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0050660//GO:0016491//GO:0016705//GO:0071949 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding -- -- KOG2311 NAD/FAD-utilizing protein possibly involved in translation Cluster-8309.28099 BF_2 25.00 0.44 2678 391339389 XP_003744034.1 2486 9.4e-278 PREDICTED: phosphoenolpyruvate carboxykinase, cytosolic [GTP]-like [Metaseiulus occidentalis] 767270364 KJ957751.1 276 4.52327e-140 Rousettus leschenaultii soluble phosphoenolpyruvate carboxykinase 1 (Pck1) mRNA, partial cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 Q5R5J1 2230 1.9e-249 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] OS=Pongo abelii GN=PCK1 PE=2 SV=1 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.281 BF_2 3.00 0.60 497 83628250 ABC26005.1 455 5.6e-43 arthrodial cuticle protein AMP16.3 [Callinectes sapidus] 83628249 DQ310582.1 343 4.52223e-178 Callinectes sapidus arthrodial cuticle protein AMP16.3 mRNA, complete cds -- -- -- -- P81384 236 5.7e-19 Cuticle protein AMP1A OS=Homarus americanus PE=1 SV=1 PF03869//PF00379 Arc-like DNA binding domain//Insect cuticle protein -- -- GO:0042302//GO:0003677 structural constituent of cuticle//DNA binding -- -- -- -- Cluster-8309.2810 BF_2 6.00 0.52 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04147 Nop14-like family -- -- -- -- GO:0032040 small-subunit processome -- -- Cluster-8309.28101 BF_2 50.59 1.33 1873 642932331 XP_008197068.1 394 2.5e-35 PREDICTED: uncharacterized protein LOC103314051 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06624//PF01284//PF07947 Ribosome associated membrane protein RAMP4//Membrane-associating domain//YhhN-like protein -- -- -- -- GO:0005783//GO:0016020//GO:0016021 endoplasmic reticulum//membrane//integral component of membrane -- -- Cluster-8309.28102 BF_2 9.00 3.81 384 270015682 EFA12130.1 539 7.8e-53 hypothetical protein TcasGA2_TC002276 [Tribolium castaneum] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 303 7.5e-27 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF01384 Phosphate transporter family GO:0006817 phosphate ion transport GO:0005315 inorganic phosphate transmembrane transporter activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28103 BF_2 430.93 10.46 2011 642937978 XP_008199153.1 1992 1.4e-220 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.16669e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 1002 3.5e-107 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304 AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28104 BF_2 57.50 0.44 5784 642937978 XP_008199153.1 5108 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 81 2.47138e-31 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2838 0.0e+00 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF11080//PF13304//PF06414//PF00005//PF03193//PF04310//PF00448 Protein of unknown function (DUF2622)//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//MukB N-terminal//SRP54-type protein, GTPase domain GO:0006614//GO:0007059//GO:0051252//GO:0030261 SRP-dependent cotranslational protein targeting to membrane//chromosome segregation//regulation of RNA metabolic process//chromosome condensation GO:0003924//GO:0004521//GO:0005524//GO:0003677//GO:0005525//GO:0016887//GO:0016301 GTPase activity//endoribonuclease activity//ATP binding//DNA binding//GTP binding//ATPase activity//kinase activity GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28107 BF_2 32.79 4.92 566 642937978 XP_008199153.1 278 2.1e-22 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28109 BF_2 30.02 0.71 2066 642937972 XP_008199150.1 1486 6.5e-162 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X3 [Tribolium castaneum] 827549661 XM_012691461.1 35 3.25483e-06 PREDICTED: Bombyx mori ATP-binding cassette sub-family A member 1-like (LOC101740368), transcript variant X2, mRNA K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 758 7.0e-79 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304 AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28110 BF_2 356.70 2.68 5862 642937978 XP_008199153.1 5110 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 76 1.50757e-28 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2835 0.0e+00 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00448//PF06414//PF13304//PF00005//PF04310//PF03193 SRP54-type protein, GTPase domain//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//MukB N-terminal//Protein of unknown function, DUF258 GO:0007059//GO:0030261//GO:0006614 chromosome segregation//chromosome condensation//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0016887//GO:0016301//GO:0005524//GO:0003677//GO:0003924 GTP binding//ATPase activity//kinase activity//ATP binding//DNA binding//GTPase activity GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.28112 BF_2 13.00 5.62 382 780089478 XP_011673857.1 240 3.7e-18 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- K15503 ANKRD44 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K15503 Q4UMH6 234 7.5e-19 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28114 BF_2 74.57 0.65 5121 282403503 NP_001164147.1 540 8.1e-52 fumble isoform 1 [Tribolium castaneum]>gi|642912441|ref|XP_008200861.1| PREDICTED: fumble isoform X1 [Tribolium castaneum] 746854770 XM_011059724.1 35 8.14653e-06 PREDICTED: Acromyrmex echinatior pantothenate kinase 3 (LOC105148170), transcript variant X9, mRNA K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q9BZ23 398 9.7e-37 Pantothenate kinase 2, mitochondrial OS=Homo sapiens GN=PANK2 PE=1 SV=3 PF00588//PF04433//PF03630 SpoU rRNA Methylase family//SWIRM domain//Fumble GO:0015937//GO:0006396//GO:0009451//GO:0015940 coenzyme A biosynthetic process//RNA processing//RNA modification//pantothenate biosynthetic process GO:0005515//GO:0008173//GO:0005524//GO:0004594//GO:0003723 protein binding//RNA methyltransferase activity//ATP binding//pantothenate kinase activity//RNA binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.28115 BF_2 1.00 0.98 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28116 BF_2 5.00 0.87 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28120 BF_2 1.52 1.26 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28121 BF_2 203.02 5.64 1794 332374190 AEE62236.1 1090 4.7e-116 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11165 DHRS7 dehydrogenase/reductase SDR family member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11165 Q9Y394 508 5.9e-50 Dehydrogenase/reductase SDR family member 7 OS=Homo sapiens GN=DHRS7 PE=1 SV=1 PF02558//PF01370//PF00106 Ketopantoate reductase PanE/ApbA//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152//GO:0015940 oxidation-reduction process//metabolic process//pantothenate biosynthetic process GO:0016491//GO:0050662//GO:0003824//GO:0008677 oxidoreductase activity//coenzyme binding//catalytic activity//2-dehydropantoate 2-reductase activity -- -- KOG1205 Predicted dehydrogenase Cluster-8309.28124 BF_2 241.62 3.98 2824 668449787 KFB39135.1 3530 0.0e+00 ATP-dependent RNA helicase [Anopheles sinensis] 572262617 XM_006609496.1 638 0 PREDICTED: Apis dorsata putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16-like (LOC102678016), mRNA K12813 DHX16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 http://www.genome.jp/dbget-bin/www_bget?ko:K12813 Q767K6 2853 0.0e+00 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 OS=Sus scrofa GN=DHX16 PE=3 SV=1 PF04408//PF14532//PF00448//PF07652//PF00437//PF00270 Helicase associated domain (HA2)//Sigma-54 interaction domain//SRP54-type protein, GTPase domain//Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase GO:0006355//GO:0006810//GO:0019079//GO:0006614 regulation of transcription, DNA-templated//transport//viral genome replication//SRP-dependent cotranslational protein targeting to membrane GO:0003676//GO:0005525//GO:0008134//GO:0008026//GO:0004386//GO:0005524 nucleic acid binding//GTP binding//transcription factor binding//ATP-dependent helicase activity//helicase activity//ATP binding GO:0005667 transcription factor complex KOG0923 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.28127 BF_2 68.64 1.12 2854 237681162 NP_001153726.1 892 6.8e-93 glyoxylate reductase/hydroxypyruvate reductase-like [Tribolium castaneum]>gi|270012386|gb|EFA08834.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC006532 [Tribolium castaneum] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 506 1.6e-49 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF03435//PF00389//PF03446//PF02826 Saccharopine dehydrogenase NADP binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0019521//GO:0055114//GO:0006098//GO:0008152 D-gluconate metabolic process//oxidation-reduction process//pentose-phosphate shunt//metabolic process GO:0004616//GO:0016616//GO:0051287//GO:0016491 phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.28129 BF_2 78.69 0.83 4271 642916479 XP_008191061.1 1715 3.8e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 2.2e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 -- -- -- -- GO:0000166 nucleotide binding -- -- KOG2295 C2H2 Zn-finger protein Cluster-8309.28130 BF_2 707.43 9.42 3428 642937035 XP_008198661.1 2836 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X2 [Tribolium castaneum] 642937034 XM_008200439.1 587 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X2, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 2028 6.3e-226 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF00400//PF09266//PF11540 WD domain, G-beta repeat//Viral DNA topoisomerase I, N-terminal//Cytoplasmic dynein 1 intermediate chain 2 GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0003916//GO:0005515//GO:0003677 DNA topoisomerase activity//protein binding//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.28131 BF_2 438.00 10.25 2075 642920385 XP_008192323.1 2134 4.8e-237 PREDICTED: UDP-glucuronosyltransferase 2C1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36514 641 2.6e-65 UDP-glucuronosyltransferase 2C1 (Fragment) OS=Oryctolagus cuniculus GN=UGT2C1 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.28132 BF_2 321.28 4.84 3063 642929465 XP_974907.2 1251 1.7e-134 PREDICTED: armadillo repeat-containing protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K486 859 2.0e-90 Armadillo repeat-containing protein 6 homolog OS=Drosophila melanogaster GN=CG5721 PE=1 SV=1 PF00514//PF02671 Armadillo/beta-catenin-like repeat//Paired amphipathic helix repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- KOG4199 Uncharacterized conserved protein Cluster-8309.28133 BF_2 243.00 10.18 1286 642932624 XP_008196925.1 916 5.1e-96 PREDICTED: prohormone-2-like [Tribolium castaneum]>gi|270012715|gb|EFA09163.1| NVP-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28135 BF_2 73.23 1.44 2411 91078618 XP_967724.1 1494 9.0e-163 PREDICTED: cytochrome P450 4d2 [Tribolium castaneum]>gi|270004875|gb|EFA01323.1| cytochrome P450 4BR3 [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 877 1.3e-92 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0016491//GO:0046872//GO:0020037//GO:0016705 iron ion binding//oxidoreductase activity//metal ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.28136 BF_2 73.21 3.00 1308 91086913 XP_971407.1 729 2.5e-74 PREDICTED: serine/threonine-protein phosphatase 5 [Tribolium castaneum]>gi|270009672|gb|EFA06120.1| hypothetical protein TcasGA2_TC008963 [Tribolium castaneum] 817223205 XM_012431486.1 112 3.20319e-49 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 622 2.6e-63 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF00149 Calcineurin-like phosphoesterase GO:0006470 protein dephosphorylation GO:0004721//GO:0046872//GO:0016787 phosphoprotein phosphatase activity//metal ion binding//hydrolase activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.28140 BF_2 14.52 0.69 1169 642932818 XP_008196998.1 1242 7.3e-134 PREDICTED: protein CLEC16A isoform X6 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 981 5.5e-105 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2219 Uncharacterized conserved protein Cluster-8309.28143 BF_2 7.82 0.56 876 546682133 ERL92114.1 299 1.2e-24 hypothetical protein D910_09435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28144 BF_2 435.33 3.23 5924 642926198 XP_008194826.1 5083 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein castor homolog 1-like [Tribolium castaneum] 645021609 XM_008209379.1 386 0 PREDICTED: Nasonia vitripennis zinc finger protein castor homolog 1-like (LOC100116283), partial mRNA -- -- -- -- Q7M3M8 884 4.9e-93 Transcription factor castor OS=Drosophila melanogaster GN=cas PE=1 SV=2 PF09026//PF06734//PF02178 Centromere protein B dimerisation domain//UL97//AT hook motif GO:0016032//GO:0006355 viral process//regulation of transcription, DNA-templated GO:0005524//GO:0003677//GO:0003682//GO:0004672 ATP binding//DNA binding//chromatin binding//protein kinase activity GO:0005634//GO:0000785//GO:0000775 nucleus//chromatin//chromosome, centromeric region -- -- Cluster-8309.28149 BF_2 582.78 4.67 5503 642927663 XP_008195354.1 1331 1.6e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.3e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.28151 BF_2 617.37 4.51 6009 189241444 XP_972982.2 3186 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X1 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.3658e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 8.2e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF02346//PF01166 Chordopoxvirus multifunctional envelope protein A27//TSC-22/dip/bun family GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0019031//GO:0005667 viral envelope//transcription factor complex -- -- Cluster-8309.28155 BF_2 201.48 2.97 3129 642927580 XP_008195323.1 2471 6.0e-276 PREDICTED: uncharacterized protein LOC661513 isoform X1 [Tribolium castaneum]>gi|642927582|ref|XP_008195324.1| PREDICTED: uncharacterized protein LOC661513 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08622 Svf1-like GO:0006979 response to oxidative stress -- -- -- -- -- -- Cluster-8309.28157 BF_2 88.00 2.26 1917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28158 BF_2 34.00 2.29 909 546672885 ERL84608.1 796 2.9e-82 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 564 9.7e-57 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00108//PF08545 Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0042967//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.28159 BF_2 758.00 33.17 1243 332375697 AEE62989.1 772 2.4e-79 unknown [Dendroctonus ponderosae] -- -- -- -- -- K04448 JUN transcription factor AP-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04448 P18289 373 1.9e-34 Transcription factor AP-1 OS=Drosophila melanogaster GN=Jra PE=1 SV=2 PF02544//PF03131//PF07716//PF00170//PF05853 3-oxo-5-alpha-steroid 4-dehydrogenase//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor//3-keto-5-aminohexanoate cleavage enzyme GO:0019475//GO:0006629//GO:0006355 L-lysine catabolic process to acetate//lipid metabolic process//regulation of transcription, DNA-templated GO:0016740//GO:0003677//GO:0043565//GO:0003700//GO:0016627 transferase activity//DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005634//GO:0005667//GO:0005737 integral component of membrane//nucleus//transcription factor complex//cytoplasm KOG0837 Transcriptional activator of the JUN family Cluster-8309.28162 BF_2 23.78 0.31 3499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05241 Emopamil binding protein GO:0016125//GO:0006694 sterol metabolic process//steroid biosynthetic process GO:0047750 cholestenol delta-isomerase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28164 BF_2 475.05 13.96 1711 57791222 AAW56441.1 199 9.3e-13 PR-5-like protein [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q9FSG7 165 3.4e-10 Thaumatin-like protein 1a OS=Malus domestica GN=TL1 PE=1 SV=1 PF05241 Emopamil binding protein GO:0006694//GO:0016125 steroid biosynthetic process//sterol metabolic process GO:0047750 cholestenol delta-isomerase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28166 BF_2 250.82 8.62 1504 478257322 ENN77482.1 595 9.9e-59 hypothetical protein YQE_06010, partial [Dendroctonus ponderosae]>gi|546679551|gb|ERL89999.1| hypothetical protein D910_07358 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VCG3 471 9.7e-46 Putative OPA3-like protein CG13603 OS=Drosophila melanogaster GN=CG13601 PE=2 SV=1 PF09429//PF05443//PF04218 WW domain binding protein 11//ROS/MUCR transcriptional regulator protein//CENP-B N-terminal DNA-binding domain GO:0006396//GO:0006355 RNA processing//regulation of transcription, DNA-templated GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG3335 Predicted coiled-coil protein Cluster-8309.28167 BF_2 16.48 0.86 1090 270005091 EFA01539.1 167 3.1e-09 hypothetical protein TcasGA2_TC007099 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28168 BF_2 7.33 0.42 1013 478251777 ENN72223.1 502 4.1e-48 hypothetical protein YQE_11086, partial [Dendroctonus ponderosae]>gi|546674687|gb|ERL86009.1| hypothetical protein D910_03423 [Dendroctonus ponderosae] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 309 4.0e-27 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF06574//PF01467 FAD synthetase//Cytidylyltransferase-like GO:0006771//GO:0009231//GO:0009058 riboflavin metabolic process//riboflavin biosynthetic process//biosynthetic process GO:0003824//GO:0003919 catalytic activity//FMN adenylyltransferase activity -- -- KOG2803 Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase Cluster-8309.28169 BF_2 424.14 5.94 3272 91083107 XP_969706.1 1373 1.3e-148 PREDICTED: mitochondrial translocator assembly and maintenance protein 41 homolog [Tribolium castaneum] -- -- -- -- -- K17807 TAM41, MMP37 mitochondrial translocator assembly and maintenance protein 41 http://www.genome.jp/dbget-bin/www_bget?ko:K17807 Q3B7H2 731 1.5e-75 Phosphatidate cytidylyltransferase, mitochondrial OS=Danio rerio GN=tamm41 PE=2 SV=1 PF06687//PF06638 SUR7/PalI family//Strabismus protein GO:0007275 multicellular organismal development -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2986 Uncharacterized conserved protein Cluster-8309.28170 BF_2 229.14 3.02 3462 642911313 XP_008199366.1 1106 1.3e-117 PREDICTED: ubiquitin carboxyl-terminal hydrolase 8-like isoform X1 [Tribolium castaneum]>gi|270014853|gb|EFA11301.1| hypothetical protein TcasGA2_TC010838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O57429 296 4.4e-25 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF00443//PF04805 Ubiquitin carboxyl-terminal hydrolase//E10-like protein conserved region GO:0055114//GO:0016579 oxidation-reduction process//protein deubiquitination GO:0016972//GO:0036459 thiol oxidase activity//ubiquitinyl hydrolase activity -- -- KOG1868 Ubiquitin C-terminal hydrolase Cluster-8309.28172 BF_2 82.88 0.74 4945 642922648 XP_008193260.1 1997 8.7e-221 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1387 1.9e-151 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF00711//PF04097 C2 domain//Beta defensin//Nup93/Nic96 GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005576//GO:0005643 extracellular region//nuclear pore KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.28173 BF_2 641.45 9.78 3031 571522843 XP_006560646.1 2547 9.0e-285 PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X1 [Apis mellifera]>gi|571522847|ref|XP_006560647.1| PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X2 [Apis mellifera]>gi|572299841|ref|XP_006616036.1| PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X1 [Apis dorsata]>gi|820834520|ref|XP_012348758.1| PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X1 [Apis florea]>gi|820834522|ref|XP_012348809.1| PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X1 [Apis florea] 642937303 XM_008200556.1 590 0 PREDICTED: Tribolium castaneum zinc finger SWIM domain-containing protein 8 (LOC659149), mRNA -- -- -- -- A7E2V4 1570 7.2e-173 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- KOG3615 Uncharacterized conserved protein Cluster-8309.28174 BF_2 1276.50 6.43 8586 642937304 XP_008198778.1 1898 4.6e-209 PREDICTED: zinc finger SWIM domain-containing protein 8 [Tribolium castaneum] 194892748 XM_001977686.1 154 9.6544e-72 Drosophila erecta GG19197 (Dere\GG19197), mRNA -- -- -- -- A7E2V4 868 5.1e-91 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 PF06554//PF02024 Olfactory marker protein//Leptin GO:0007165//GO:0007608 signal transduction//sensory perception of smell GO:0004871//GO:0005179 signal transducer activity//hormone activity GO:0005576 extracellular region KOG3615 Uncharacterized conserved protein Cluster-8309.28175 BF_2 811.22 6.40 5587 646717479 KDR20323.1 3194 0.0e+00 Adenylate cyclase type 2 [Zootermopsis nevadensis] 769847817 XM_011636959.1 159 1.04192e-74 PREDICTED: Pogonomyrmex barbatus adenylate cyclase type 2 (LOC105425936), transcript variant X4, mRNA K08042 ADCY2 adenylate cyclase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08042 Q08462 1839 8.5e-204 Adenylate cyclase type 2 OS=Homo sapiens GN=ADCY2 PE=1 SV=5 PF00211//PF07701//PF06327 Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated//Domain of Unknown Function (DUF1053) GO:0009190//GO:0035556//GO:0006171//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//cAMP biosynthetic process//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0004016//GO:0016849//GO:0004383 adenylate cyclase activity//phosphorus-oxygen lyase activity//guanylate cyclase activity GO:0005886 plasma membrane -- -- Cluster-8309.28176 BF_2 2228.29 18.63 5291 642918882 XP_008191626.1 2269 2.7e-252 PREDICTED: E3 ubiquitin-protein ligase TRIM33-like [Tribolium castaneum] 817217743 XM_012429361.1 488 0 PREDICTED: Orussus abietinus serine/threonine-protein kinase minibrain (LOC105702083), transcript variant X2, mRNA K08825 DYRK1 dual specificity tyrosine-phosphorylation-regulated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08825 P49657 1844 2.1e-204 Serine/threonine-protein kinase minibrain OS=Drosophila melanogaster GN=mnb PE=2 SV=2 PF07714//PF06180//PF01399//PF00069 Protein tyrosine kinase//Cobalt chelatase (CbiK)//PCI domain//Protein kinase domain GO:0006468//GO:0006783//GO:0019251 protein phosphorylation//heme biosynthetic process//anaerobic cobalamin biosynthetic process GO:0004672//GO:0005515//GO:0016852//GO:0005524 protein kinase activity//protein binding//sirohydrochlorin cobaltochelatase activity//ATP binding -- -- KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.28180 BF_2 1076.14 15.59 3175 91087645 XP_973337.1 857 8.7e-89 PREDICTED: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein [Tribolium castaneum]>gi|270010715|gb|EFA07163.1| hypothetical protein TcasGA2_TC010160 [Tribolium castaneum] -- -- -- -- -- K10904 TIPIN TIMELESS-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K10904 Q9BSE4 309 1.3e-26 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein OS=Homo sapiens GN=HERPUD2 PE=1 SV=2 PF03153//PF03623//PF00240//PF04513//PF05238//PF07962 Transcription factor IIA, alpha/beta subunit//Focal adhesion targeting region//Ubiquitin family//Baculovirus polyhedron envelope protein, PEP, C terminus//Kinetochore protein CHL4 like//Replication Fork Protection Component Swi3 GO:0007172//GO:0006367//GO:0007165//GO:0006468//GO:0006974//GO:0034508//GO:0007049//GO:0007059//GO:0048478 signal complex assembly//transcription initiation from RNA polymerase II promoter//signal transduction//protein phosphorylation//cellular response to DNA damage stimulus//centromere complex assembly//cell cycle//chromosome segregation//replication fork protection GO:0004713//GO:0005515//GO:0004871//GO:0005198 protein tyrosine kinase activity//protein binding//signal transducer activity//structural molecule activity GO:0005634//GO:0019031//GO:0005672//GO:0019028//GO:0005925 nucleus//viral envelope//transcription factor TFIIA complex//viral capsid//focal adhesion KOG3004 Meiotic chromosome segregation protein Cluster-8309.28181 BF_2 44.15 0.93 2271 642927745 XP_008195389.1 592 3.3e-58 PREDICTED: trafficking protein particle complex subunit 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXJ6 389 4.7e-36 Trafficking protein particle complex subunit 2-like protein OS=Taeniopygia guttata GN=TRAPPC2L PE=2 SV=1 PF13506//PF04628//PF04099 Glycosyl transferase family 21//Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport GO:0016757 transferase activity, transferring glycosyl groups GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3444 Uncharacterized conserved protein Cluster-8309.28182 BF_2 270.63 6.61 2000 642927745 XP_008195389.1 646 1.6e-64 PREDICTED: trafficking protein particle complex subunit 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXJ6 429 9.6e-41 Trafficking protein particle complex subunit 2-like protein OS=Taeniopygia guttata GN=TRAPPC2L PE=2 SV=1 PF04099//PF04628 Sybindin-like family//Sedlin, N-terminal conserved region GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3444 Uncharacterized conserved protein Cluster-8309.28183 BF_2 8.22 1.06 612 642927745 XP_008195389.1 204 8.8e-14 PREDICTED: trafficking protein particle complex subunit 2-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5FXJ6 132 8.1e-07 Trafficking protein particle complex subunit 2-like protein OS=Taeniopygia guttata GN=TRAPPC2L PE=2 SV=1 PF04099//PF04628 Sybindin-like family//Sedlin, N-terminal conserved region GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular -- -- Cluster-8309.28184 BF_2 284.28 2.76 4593 642938167 XP_008190994.1 397 2.8e-35 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04644//PF00002 Motilin/ghrelin//7 transmembrane receptor (Secretin family) GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005179//GO:0004930 hormone activity//G-protein coupled receptor activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.28185 BF_2 344.64 8.59 1965 91080393 XP_966637.1 1661 3.2e-182 PREDICTED: rab proteins geranylgeranyltransferase component A 1 [Tribolium castaneum]>gi|270005742|gb|EFA02190.1| hypothetical protein TcasGA2_TC007846 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V8W3 797 2.0e-83 Rab proteins geranylgeranyltransferase component A OS=Drosophila melanogaster GN=Rep PE=2 SV=1 PF12831 FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG4405 GDP dissociation inhibitor Cluster-8309.28186 BF_2 109.09 0.86 5616 373159261 AEY63780.1 1981 7.1e-219 ecdysone receptor isoform A [Monochamus alternatus] 373159260 JN616374.1 1051 0 Monochamus alternatus ecdysone receptor isoform A mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1313 8.4e-143 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.28187 BF_2 370.56 2.93 5586 373159263 AEY63781.1 2431 4.7e-271 ecdysone receptor isoform B [Monochamus alternatus] 373159262 JN616375.1 1222 0 Monochamus alternatus ecdysone receptor isoform B mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 O18531 1337 1.4e-145 Ecdysone receptor OS=Lucilia cuprina GN=EcR PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.28191 BF_2 34.50 0.53 3024 642929609 XP_008195902.1 1940 2.2e-214 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] 642929608 XM_008197680.1 49 7.89779e-14 PREDICTED: Tribolium castaneum FAS-associated factor 1 (LOC664346), mRNA -- -- -- -- Q9UNN5 797 3.1e-83 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF00240//PF09226 Ubiquitin family//Restriction endonuclease HincII GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0009036//GO:0003677//GO:0005515 Type II site-specific deoxyribonuclease activity//DNA binding//protein binding GO:0009359 Type II site-specific deoxyribonuclease complex KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.28193 BF_2 11.00 0.52 1167 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28194 BF_2 23.13 0.34 3121 642913640 XP_008201099.1 2668 8.6e-299 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum]>gi|642913648|ref|XP_008201103.1| PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 2.7e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF03539//PF01055 Spumavirus aspartic protease (A9)//Glycosyl hydrolases family 31 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004553//GO:0004190 hydrolase activity, hydrolyzing O-glycosyl compounds//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.28195 BF_2 9.00 0.75 788 91081147 XP_975562.1 188 8.1e-12 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270006377|gb|EFA02825.1| cytochrome P450 6BQ12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4U9 129 2.3e-06 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0004497//GO:0020037//GO:0005506 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//monooxygenase activity//heme binding//iron ion binding -- -- -- -- Cluster-8309.28196 BF_2 57.14 0.49 5136 642912135 XP_008200821.1 2369 6.6e-264 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3-like [Tribolium castaneum] -- -- -- -- -- K08619 ADAMTS3 a disintegrin and metalloproteinase with thrombospondin motifs 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08619 O95450 1169 3.8e-126 A disintegrin and metalloproteinase with thrombospondin motifs 2 OS=Homo sapiens GN=ADAMTS2 PE=2 SV=2 PF05372//PF01421//PF08686 Delta lysin family//Reprolysin (M12B) family zinc metalloprotease//PLAC (protease and lacunin) domain GO:0019836//GO:0006508 hemolysis by symbiont of host erythrocytes//proteolysis GO:0004222//GO:0008233 metalloendopeptidase activity//peptidase activity GO:0005576 extracellular region -- -- Cluster-8309.282 BF_2 1.00 11.84 229 83628250 ABC26005.1 159 5.3e-09 arthrodial cuticle protein AMP16.3 [Callinectes sapidus] 83628249 DQ310582.1 115 1.06644e-51 Callinectes sapidus arthrodial cuticle protein AMP16.3 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28201 BF_2 1056.57 4.26 10665 478253985 ENN74277.1 1873 4.5e-206 hypothetical protein YQE_09249, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7Z026 362 3.0e-32 Protein phosphatase 1 regulatory subunit 37 OS=Bos taurus GN=PPP1R37 PE=2 SV=1 PF07123//PF13855//PF13516//PF14604//PF00560//PF00018 Photosystem II reaction centre W protein (PsbW)//Leucine rich repeat//Leucine Rich repeat//Variant SH3 domain//Leucine Rich Repeat//SH3 domain GO:0015979 photosynthesis GO:0005515 protein binding GO:0009523//GO:0009507 photosystem II//chloroplast -- -- Cluster-8309.28203 BF_2 11.69 0.66 1023 282158105 NP_001164096.1 374 2.9e-33 diuretic hormone 37 like protein [Tribolium castaneum]>gi|270016218|gb|EFA12664.1| diuretic hormone 37 like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00473 Corticotropin-releasing factor family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.28204 BF_2 35.00 0.47 3414 270004166 EFA00614.1 166 1.3e-08 hypothetical protein TcasGA2_TC003489 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28210 BF_2 135.00 34.39 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28213 BF_2 739.00 18.23 1983 91081015 XP_975227.1 621 1.3e-61 PREDICTED: uncharacterized protein LOC664119 [Tribolium castaneum]>gi|270005332|gb|EFA01780.1| hypothetical protein TcasGA2_TC007381 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00020//PF03839 TNFR/NGFR cysteine-rich region//Translocation protein Sec62 GO:0015031 protein transport GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28217 BF_2 843.60 2.66 13544 189234010 XP_972656.2 5202 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2428 1.0e-271 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF08926//PF00069//PF06293//PF00595//PF00412//PF07714//PF13180 Domain of unknown function (DUF1908)//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain (Also known as DHR or GLGF)//LIM domain//Protein tyrosine kinase//PDZ domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0004674//GO:0000287//GO:0008270//GO:0016773 protein binding//ATP binding//protein kinase activity//protein serine/threonine kinase activity//magnesium ion binding//zinc ion binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.28219 BF_2 4.00 0.47 643 91089927 XP_973012.1 170 8.1e-10 PREDICTED: uncharacterized protein LOC661778 [Tribolium castaneum]>gi|270013560|gb|EFA10008.1| hypothetical protein TcasGA2_TC012178 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01542 Hepatitis C virus core protein -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.28221 BF_2 12.21 1.17 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28222 BF_2 45.16 5.03 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28223 BF_2 85.21 1.45 2738 642935026 XP_008199911.1 218 9.4e-15 PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|642935028|ref|XP_008199912.1| PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|270012981|gb|EFA09429.1| hypothetical protein TcasGA2_TC010640 [Tribolium castaneum] -- -- -- -- -- K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q3T106 141 3.3e-07 Serine/arginine-rich splicing factor 7 OS=Bos taurus GN=SRSF7 PE=2 SV=1 PF01080//PF00098 Presenilin//Zinc knuckle -- -- GO:0005488//GO:0008270//GO:0003676//GO:0004190 binding//zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.28224 BF_2 219.09 10.24 1182 642936522 XP_008198471.1 738 2.0e-75 PREDICTED: BRCA1-A complex subunit BRE-like [Tribolium castaneum]>gi|270014127|gb|EFA10575.1| hypothetical protein TcasGA2_TC012831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6SP92 375 1.0e-34 BRCA1-A complex subunit BRE OS=Mesocricetus auratus GN=Bre PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28225 BF_2 690.93 8.90 3535 642923099 XP_008193609.1 2159 1.0e-239 PREDICTED: STE20/SPS1-related proline-alanine-rich protein kinase [Tribolium castaneum] 826417085 XM_012667875.1 233 4.79769e-116 PREDICTED: Monomorium pharaonis serine/threonine-protein kinase OSR1 (LOC105829196), transcript variant X2, mRNA K08835 OXSR1, STK39 serine/threonine-protein kinase OSR1/STK39 http://www.genome.jp/dbget-bin/www_bget?ko:K08835 Q863I2 1131 6.7e-122 Serine/threonine-protein kinase OSR1 OS=Sus scrofa GN=OXSR1 PE=2 SV=1 PF00069//PF07714//PF12202 Protein kinase domain//Protein tyrosine kinase//Oxidative-stress-responsive kinase 1 C terminal GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0582 Ste20-like serine/threonine protein kinase Cluster-8309.28228 BF_2 147.52 0.92 7030 91078242 XP_970298.1 3559 0.0e+00 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 642939064 XM_008201985.1 402 0 PREDICTED: Tribolium castaneum xenotropic and polytropic retrovirus receptor 1 (LOC100142189), transcript variant X2, mRNA -- -- -- -- Q9UBH6 1815 6.5e-201 Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens GN=XPR1 PE=1 SV=1 PF01504//PF03124 Phosphatidylinositol-4-phosphate 5-Kinase//EXS family GO:0046488 phosphatidylinositol metabolic process GO:0043167//GO:0016307 ion binding//phosphatidylinositol phosphate kinase activity GO:0016021 integral component of membrane KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.2823 BF_2 2.89 0.65 474 642928441 XP_008193786.1 251 2.4e-19 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28233 BF_2 13.00 3.23 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28234 BF_2 1656.26 25.83 2970 642916978 XP_008199580.1 1215 2.5e-130 PREDICTED: leukocyte receptor cluster member 8 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32NW2 800 1.4e-83 Leukocyte receptor cluster member 8 homolog OS=Xenopus laevis GN=leng8 PE=2 SV=1 PF01785//PF02978 Closterovirus coat protein//Signal peptide binding domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500//GO:0019012 signal recognition particle//virion KOG1861 Leucine permease transcriptional regulator Cluster-8309.28237 BF_2 1237.71 10.71 5121 642916974 XP_008199578.1 1043 3.8e-110 PREDICTED: leukocyte receptor cluster member 8 homolog isoform X1 [Tribolium castaneum]>gi|642916976|ref|XP_008199579.1| PREDICTED: leukocyte receptor cluster member 8 homolog isoform X1 [Tribolium castaneum]>gi|270003023|gb|EEZ99470.1| hypothetical protein TcasGA2_TC000041 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CBY3 733 1.4e-75 Leukocyte receptor cluster member 8 homolog OS=Mus musculus GN=Leng8 PE=1 SV=1 PF02978//PF01785 Signal peptide binding domain//Closterovirus coat protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0048500//GO:0019012 signal recognition particle//virion KOG1861 Leucine permease transcriptional regulator Cluster-8309.28238 BF_2 93.00 1.40 3058 642919488 XP_008191892.1 765 3.9e-78 PREDICTED: neuroglobin [Tribolium castaneum] 642919487 XM_008193670.1 226 3.22598e-112 PREDICTED: Tribolium castaneum neuroglobin (LOC663615), mRNA -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.2824 BF_2 7.87 0.55 885 642928441 XP_008193786.1 414 5.7e-38 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28240 BF_2 176.70 5.96 1527 91094389 XP_971252.1 775 1.4e-79 PREDICTED: DNA polymerase epsilon subunit C [Tribolium castaneum] 642910354 XM_966159.2 148 3.6495e-69 PREDICTED: Tribolium castaneum DNA polymerase epsilon subunit C (LOC659892), mRNA -- -- -- -- Q2YDP3 375 1.3e-34 Dr1-associated corepressor OS=Bos taurus GN=DRAP1 PE=2 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1659 Class 2 transcription repressor NC2, alpha subunit (DRAP1) Cluster-8309.28242 BF_2 83.00 1.11 3410 642912548 XP_008200908.1 187 4.6e-11 PREDICTED: collagen and calcium-binding EGF domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28243 BF_2 109.37 3.67 1533 270004866 EFA01314.1 291 1.8e-23 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K05465 ANGPT1 angiopoietin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05465 O18920 240 6.1e-19 Angiopoietin-1 OS=Bos taurus GN=ANGPT1 PE=2 SV=3 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.28245 BF_2 856.56 6.65 5678 478257634 ENN77786.1 3093 0.0e+00 hypothetical protein YQE_05757, partial [Dendroctonus ponderosae] -- -- -- -- -- K16602 TTLL5, TTLL10 tubulin polyglutamylase TTLL5 http://www.genome.jp/dbget-bin/www_bget?ko:K16602 Q8CHB8 1216 1.5e-131 Tubulin polyglutamylase TTLL5 OS=Mus musculus GN=Ttll5 PE=2 SV=3 PF02655//PF03133 ATP-grasp domain//Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process GO:0046872//GO:0005524 metal ion binding//ATP binding -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.28246 BF_2 66.01 0.50 5816 478257634 ENN77786.1 3093 0.0e+00 hypothetical protein YQE_05757, partial [Dendroctonus ponderosae] -- -- -- -- -- K16602 TTLL5, TTLL10 tubulin polyglutamylase TTLL5 http://www.genome.jp/dbget-bin/www_bget?ko:K16602 Q8CHB8 1216 1.5e-131 Tubulin polyglutamylase TTLL5 OS=Mus musculus GN=Ttll5 PE=2 SV=3 PF02655//PF03133 ATP-grasp domain//Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process GO:0046872//GO:0005524 metal ion binding//ATP binding -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.28249 BF_2 327.00 6.61 2358 86515378 NP_001034514.1 2289 5.8e-255 laccase 1 [Tribolium castaneum]>gi|642912767|ref|XP_008201239.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|642912769|ref|XP_008201241.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|642912771|ref|XP_008201242.1| PREDICTED: laccase 1 isoform X1 [Tribolium castaneum]>gi|68137818|gb|AAX84206.1| laccase 1 [Tribolium castaneum]>gi|270001917|gb|EEZ98364.1| hypothetical protein TcasGA2_TC000821 [Tribolium castaneum] 645006023 XM_008206069.1 60 4.71459e-20 PREDICTED: Nasonia vitripennis L-ascorbate oxidase-like (LOC100121373), mRNA -- -- -- -- Q96WM9 432 5.1e-41 Laccase-2 OS=Botryotinia fuckeliana GN=lcc2 PE=2 SV=1 PF07731//PF07732//PF00394 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0005507 metal ion binding//oxidoreductase activity//copper ion binding -- -- KOG1263 Multicopper oxidases Cluster-8309.2825 BF_2 20.24 1.38 900 642928441 XP_008193786.1 414 5.8e-38 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28255 BF_2 296.20 2.03 6387 642926766 XP_008195005.1 4458 0.0e+00 PREDICTED: copper-transporting ATPase 1 isoform X1 [Tribolium castaneum] 827557043 XM_012694365.1 41 4.69827e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2576 3.4e-289 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF05138//PF00122//PF01529//PF00403 Phenylacetic acid catabolic protein//E1-E2 ATPase//DHHC palmitoyltransferase//Heavy-metal-associated domain GO:0010124//GO:0030001 phenylacetate catabolic process//metal ion transport GO:0046872//GO:0008270//GO:0000166 metal ion binding//zinc ion binding//nucleotide binding -- -- KOG0207 Cation transport ATPase Cluster-8309.28256 BF_2 1.06 1.17 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28257 BF_2 16.00 0.83 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.28260 BF_2 255.42 6.24 2000 91078258 XP_970899.1 1875 5.0e-207 PREDICTED: conserved oligomeric Golgi complex subunit 6 [Tribolium castaneum]>gi|270003921|gb|EFA00369.1| hypothetical protein TcasGA2_TC003211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V564 1377 1.1e-150 Conserved oligomeric Golgi complex subunit 6 OS=Drosophila melanogaster GN=CG1968 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3758 Uncharacterized conserved protein Cluster-8309.28262 BF_2 296.00 6.37 2232 642910457 XP_008190746.1 2112 1.8e-234 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum]>gi|642910459|ref|XP_008190747.1| PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum] 462340826 APGK01036266.1 75 2.04536e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q09147 1216 5.9e-132 Fibroblast growth factor receptor homolog 2 OS=Drosophila melanogaster GN=btl PE=2 SV=3 PF13895//PF02313//PF00069//PF06305//PF07714 Immunoglobulin domain//Fumarate reductase subunit D//Protein kinase domain//Protein of unknown function (DUF1049)//Protein tyrosine kinase GO:0006106//GO:0006468 fumarate metabolic process//protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity GO:0016020//GO:0005887 membrane//integral component of plasma membrane -- -- Cluster-8309.28263 BF_2 146.07 7.10 1148 642910457 XP_008190746.1 468 4.0e-44 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum]>gi|642910459|ref|XP_008190747.1| PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 268 2.6e-22 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28264 BF_2 20.19 0.31 3002 642910461 XP_008190748.1 2005 6.3e-222 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] 462340826 APGK01036266.1 75 2.76042e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1199 7.5e-130 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF02313//PF00069//PF07714//PF06305 Fumarate reductase subunit D//Protein kinase domain//Protein tyrosine kinase//Protein of unknown function (DUF1049) GO:0006106//GO:0006468 fumarate metabolic process//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.28266 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28267 BF_2 3.00 0.79 445 270015126 EFA11574.1 153 5.2e-08 heartless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28269 BF_2 103.00 2.27 2186 91081337 XP_970723.1 999 2.0e-105 PREDICTED: retinol dehydrogenase 12 [Tribolium castaneum]>gi|270006107|gb|EFA02555.1| hypothetical protein TcasGA2_TC008262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5I4 408 2.9e-38 Dehydrogenase/reductase SDR family member on chromosome X OS=Homo sapiens GN=DHRSX PE=2 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.28270 BF_2 1012.00 70.23 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28271 BF_2 213.72 2.09 4561 642910521 XP_008200247.1 918 1.1e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28273 BF_2 219.82 3.75 2737 91088333 XP_970609.1 1155 2.1e-123 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 706 1.0e-72 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00083//PF15281 Major Facilitator Superfamily//Sugar (and other) transporter//Consortin C-terminus GO:0042998//GO:0055085 positive regulation of Golgi to plasma membrane protein transport//transmembrane transport GO:0071253//GO:0022857 connexin binding//transmembrane transporter activity GO:0005802//GO:0016021 trans-Golgi network//integral component of membrane -- -- Cluster-8309.2828 BF_2 2.00 0.56 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28281 BF_2 113.48 5.88 1094 642919584 XP_975311.2 687 1.5e-69 PREDICTED: probable trafficking protein particle complex subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUZ1 531 7.8e-53 Probable trafficking protein particle complex subunit 2 OS=Drosophila melanogaster GN=Trs20 PE=2 SV=2 PF04628//PF04099 Sedlin, N-terminal conserved region//Sybindin-like family GO:0006888 ER to Golgi vesicle-mediated transport -- -- GO:0005801//GO:0005622 cis-Golgi network//intracellular KOG3487 TRAPP 20 K subunit Cluster-8309.28282 BF_2 44.58 0.76 2757 91085407 XP_967344.1 1098 8.6e-117 PREDICTED: peroxisome assembly protein 12 [Tribolium castaneum] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 2.0e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF07685//PF13639//PF12678//PF00097 CobB/CobQ-like glutamine amidotransferase domain//Ring finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0046872//GO:0008270//GO:0003824 protein binding//metal ion binding//zinc ion binding//catalytic activity -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.28285 BF_2 27.95 0.52 2536 189240740 XP_968238.2 521 6.4e-50 PREDICTED: phospholipase A-2-activating protein [Tribolium castaneum] -- -- -- -- -- K03963 NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03963 Q02368 265 1.3e-21 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 OS=Bos taurus GN=NDUFB7 PE=1 SV=2 PF05676 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0006118//GO:0006814//GO:0006744//GO:0015992//GO:0006120 obsolete electron transport//sodium ion transport//ubiquinone biosynthetic process//proton transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003954 NADH dehydrogenase (ubiquinone) activity//NADH dehydrogenase activity GO:0005739 mitochondrion KOG3468 NADH:ubiquinone oxidoreductase, NDUFB7/B18 subunit Cluster-8309.28286 BF_2 30.04 0.35 3892 642925008 XP_008194132.1 2136 5.2e-237 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X2 [Tribolium castaneum] 687916150 LK995546.1 47 1.31843e-12 Rhabditophanes sp. KR3021 genome assembly Rhabditophanes_sp_KR3021 ,scaffold RSKR_scaffold0000001 K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 1763 3.9e-195 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03485//PF05236//PF15014//PF03540 Arginyl tRNA synthetase N terminal domain//Transcription initiation factor TFIID component TAF4 family//Ceroid-lipofuscinosis neuronal protein 5//Transcription initiation factor TFIID 23-30kDa subunit GO:0006352//GO:0006420//GO:0006560//GO:0022008//GO:0006525 DNA-templated transcription, initiation//arginyl-tRNA aminoacylation//proline metabolic process//neurogenesis//arginine metabolic process GO:0000166//GO:0004814//GO:0005524 nucleotide binding//arginine-tRNA ligase activity//ATP binding GO:0005737//GO:0005669//GO:0005764//GO:0005634 cytoplasm//transcription factor TFIID complex//lysosome//nucleus KOG3635 Phosphorylase kinase Cluster-8309.28287 BF_2 149.00 2.05 3332 642929247 XP_008195752.1 173 1.9e-09 PREDICTED: uncharacterized protein LOC103313669 [Tribolium castaneum]>gi|270010484|gb|EFA06932.1| hypothetical protein TcasGA2_TC009882 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09788 Transmembrane protein 55A GO:0046856 phosphatidylinositol dephosphorylation GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity -- -- -- -- Cluster-8309.28288 BF_2 1301.53 14.01 4174 642925626 XP_008194646.1 3000 0.0e+00 PREDICTED: endothelin-converting enzyme 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P42893 1657 8.1e-183 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01447//PF01431 Peptidase family M13//Thermolysin metallopeptidase, catalytic domain//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.28290 BF_2 870.04 8.70 4471 642912875 XP_008201292.1 4481 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1050 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1712 3.6e-189 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00609//PF00788//PF00076//PF00781 Diacylglycerol kinase accessory domain//Ras association (RalGDS/AF-6) domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase catalytic domain GO:0009395//GO:0007205//GO:0007165//GO:0046486//GO:0035556 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//signal transduction//glycerolipid metabolic process//intracellular signal transduction GO:0004143//GO:0046872//GO:0003676//GO:0016301//GO:0000166 diacylglycerol kinase activity//metal ion binding//nucleic acid binding//kinase activity//nucleotide binding GO:0005622 intracellular KOG1169 Diacylglycerol kinase Cluster-8309.28291 BF_2 28.00 0.88 1614 391339548 XP_003744110.1 2305 5.5e-257 PREDICTED: elongation factor 2-like [Metaseiulus occidentalis] 195384729 XM_002051029.1 482 0 Drosophila virilis GJ14167 (Dvir\GJ14167), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 P13060 2140 3.1e-239 Elongation factor 2 OS=Drosophila melanogaster GN=EF2 PE=1 SV=4 PF03144//PF01926 Elongation factor Tu domain 2//50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.28292 BF_2 12.00 0.49 1302 442565874 AGC56217.1 1579 6.8e-173 translation elongation factor 2, partial [Dermatophagoides farinae] 170029843 XM_001842749.1 337 2.67128e-174 Culex quinquefasciatus elongation factor 2, mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q90705 1468 2.1e-161 Elongation factor 2 OS=Gallus gallus GN=EEF2 PE=1 SV=3 PF03764//PF03139 Elongation factor G, domain IV//Vanadium/alternative nitrogenase delta subunit GO:0019337//GO:0009399//GO:0006807//GO:0055114 tetrachloroethylene catabolic process//nitrogen fixation//nitrogen compound metabolic process//oxidation-reduction process GO:0005525//GO:0016163 GTP binding//nitrogenase activity GO:0016610 nitrogenase complex KOG0469 Elongation factor 2 Cluster-8309.28293 BF_2 206.12 2.80 3363 642926733 XP_008194990.1 2284 3.1e-254 PREDICTED: protein Malvolio isoform X2 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.9e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01566//PF08089//PF15168 Natural resistance-associated macrophage protein//Huwentoxin-II family//Triple QxxK/R motif-containing protein family GO:0009405//GO:0006810 pathogenesis//transport GO:0005215 transporter activity GO:0005576//GO:0016020//GO:0005789 extracellular region//membrane//endoplasmic reticulum membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.28294 BF_2 39.00 3.70 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28295 BF_2 47.61 3.12 926 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28296 BF_2 312.87 1.82 7482 91081101 XP_975504.1 3888 0.0e+00 PREDICTED: DNA topoisomerase 3-beta-1 [Tribolium castaneum]>gi|270005298|gb|EFA01746.1| hypothetical protein TcasGA2_TC007344 [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 O95985 2923 0.0e+00 DNA topoisomerase 3-beta-1 OS=Homo sapiens GN=TOP3B PE=1 SV=1 PF13855//PF04421//PF01131//PF00560 Leucine rich repeat//Mss4 protein//DNA topoisomerase//Leucine Rich Repeat GO:0006265//GO:0007264//GO:0043087 DNA topological change//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005515//GO:0003916//GO:0003677//GO:0003917//GO:0005085 protein binding//DNA topoisomerase activity//DNA binding//DNA topoisomerase type I activity//guanyl-nucleotide exchange factor activity GO:0005694 chromosome KOG1956 DNA topoisomerase III alpha Cluster-8309.28298 BF_2 9.11 4.82 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28299 BF_2 19.29 0.67 1496 820805576 AKG92779.1 314 3.8e-26 dimmed [Leptinotarsa decemlineata] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 200 2.6e-14 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.28300 BF_2 36.20 0.63 2684 270012119 EFA08567.1 489 3.5e-46 hypothetical protein TcasGA2_TC006222 [Tribolium castaneum] -- -- -- -- -- K08040 BHLHB8, MIST1 class B basic helix-loop-helix protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08040 B6VQA1 193 3.0e-13 Protein dimmed OS=Drosophila melanogaster GN=dimm PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.28301 BF_2 297.82 9.93 1542 91094739 XP_971002.1 702 4.0e-71 PREDICTED: uncharacterized protein LOC659618 [Tribolium castaneum]>gi|270010786|gb|EFA07234.1| hypothetical protein TcasGA2_TC010591 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BN57 213 8.3e-16 Protein C3orf33 homolog OS=Mus musculus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28302 BF_2 2.00 0.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28304 BF_2 285.98 4.22 3119 546679851 ERL90239.1 1039 6.7e-110 hypothetical protein D910_07592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83548 613 6.9e-62 Vanin-like protein 3 OS=Drosophila melanogaster GN=CG32750 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.28305 BF_2 160.53 2.48 2994 270007326 EFA03774.1 1530 7.5e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 843 1.4e-88 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF02456//PF01612//PF08066 Adenovirus IVa2 protein//3'-5' exonuclease//PMC2NT (NUC016) domain GO:0006139//GO:0006396//GO:0019083 nucleobase-containing compound metabolic process//RNA processing//viral transcription GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.28306 BF_2 42.87 0.43 4485 189237458 XP_967667.2 1458 2.5e-158 PREDICTED: solute carrier family 35 member E2-like [Tribolium castaneum] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 857 5.1e-90 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.28308 BF_2 1.10 2.32 283 642935116 XP_008197894.1 328 1.7e-28 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 261 4.1e-22 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.28311 BF_2 313.02 2.06 6637 675379920 KFM72822.1 1258 5.8e-135 Transposable element P transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07967 THAP domain//C3HC zinc finger-like -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28313 BF_2 271.90 1.75 6798 546680752 ERL90967.1 872 3.4e-90 hypothetical protein D910_08309 [Dendroctonus ponderosae] 225543471 NM_001145912.1 198 2.65067e-96 Tribolium castaneum synaptotagmin 1 (Syt1), mRNA K15290 SYT1 synaptotagmin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15290 P21521 764 4.7e-79 Synaptotagmin 1 OS=Drosophila melanogaster GN=Syt1 PE=1 SV=3 PF03821//PF05478//PF00168 Golgi 4-transmembrane spanning transporter//Prominin//C2 domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.28314 BF_2 305.00 4.88 2904 332374358 AEE62320.1 1962 5.9e-217 unknown [Dendroctonus ponderosae]>gi|478257144|gb|ENN77307.1| hypothetical protein YQE_06133, partial [Dendroctonus ponderosae]>gi|546681450|gb|ERL91547.1| hypothetical protein D910_08877 [Dendroctonus ponderosae] -- -- -- -- -- K14406 CSTF1 cleavage stimulation factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14406 Q05048 1272 2.5e-138 Cleavage stimulation factor subunit 1 OS=Homo sapiens GN=CSTF1 PE=1 SV=1 PF00578//PF00085//PF02532//PF01323//PF00400//PF01400 AhpC/TSA family//Thioredoxin//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//DSBA-like thioredoxin domain//WD domain, G-beta repeat//Astacin (Peptidase family M12A) GO:0015979//GO:0006118//GO:0006508//GO:0055114//GO:0045454 photosynthesis//obsolete electron transport//proteolysis//oxidation-reduction process//cell redox homeostasis GO:0004222//GO:0005515//GO:0016491//GO:0016209//GO:0015035 metalloendopeptidase activity//protein binding//oxidoreductase activity//antioxidant activity//protein disulfide oxidoreductase activity GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center KOG0640 mRNA cleavage stimulating factor complex; subunit 1 Cluster-8309.28315 BF_2 194.00 6.21 1594 795014013 XP_011883732.1 194 3.3e-12 PREDICTED: uncharacterized protein LOC105570890 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q9SDW0 127 8.0e-06 Trihelix transcription factor GT-3a OS=Arabidopsis thaliana GN=GT-3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28319 BF_2 142.80 1.04 6034 270011049 EFA07497.1 1806 1.5e-198 schnurri [Tribolium castaneum] -- -- -- -- -- K09239 HIVEP human immunodeficiency virus type I enhancer-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09239 A2A884 339 7.9e-30 Transcription factor HIVEP3 OS=Mus musculus GN=Hivep3 PE=1 SV=1 PF00096//PF13465//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- -- -- Cluster-8309.28320 BF_2 505.18 10.89 2228 820805528 AKG92755.1 1053 1.1e-111 hairy [Leptinotarsa decemlineata] 529156840 KC999046.1 46 2.69768e-12 Platynereis dumerilii hairy enhancer of split 8 (Hes8) mRNA, complete cds K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 P14003 574 1.6e-57 Protein hairy OS=Drosophila melanogaster GN=h PE=1 SV=2 PF00010//PF07527 Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.28323 BF_2 20.39 0.48 2050 91094295 XP_971662.1 1658 7.4e-182 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 1449 5.2e-159 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF02770//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.28324 BF_2 29.00 0.50 2694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01254//PF06495//PF04940 Nuclear transition protein 2//Fruit fly transformer protein//Sensors of blue-light using FAD GO:0007283//GO:0046660//GO:0006397//GO:0007165 spermatogenesis//female sex differentiation//mRNA processing//signal transduction GO:0071949//GO:0003677//GO:0009882 FAD binding//DNA binding//blue light photoreceptor activity GO:0000786//GO:0005634 nucleosome//nucleus -- -- Cluster-8309.28325 BF_2 323.00 86.46 443 270016365 EFA12811.1 175 1.5e-10 hypothetical protein TcasGA2_TC001876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28327 BF_2 406.00 12.49 1647 91079450 XP_969249.1 1799 2.7e-198 PREDICTED: venom serine carboxypeptidase [Tribolium castaneum]>gi|270016070|gb|EFA12518.1| hypothetical protein TcasGA2_TC002692 [Tribolium castaneum] -- -- -- -- -- K09645 CPVL vitellogenic carboxypeptidase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K09645 C9WMM5 1369 7.9e-150 Venom serine carboxypeptidase OS=Apis mellifera PE=2 SV=1 PF00450 Serine carboxypeptidase GO:0006508 proteolysis GO:0004185 serine-type carboxypeptidase activity -- -- KOG1282 Serine carboxypeptidases (lysosomal cathepsin A) Cluster-8309.28329 BF_2 261.70 1.74 6590 768438384 XP_011560772.1 315 1.3e-25 PREDICTED: transient receptor potential cation channel protein painless [Plutella xylostella]>gi|768438386|ref|XP_011560773.1| PREDICTED: transient receptor potential cation channel protein painless [Plutella xylostella] -- -- -- -- -- -- -- -- -- O90760 163 2.2e-09 Putative ankyrin repeat protein FPV031 OS=Fowlpox virus (strain NVSL) GN=ANK3 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28330 BF_2 163.30 1.11 6466 768438384 XP_011560772.1 315 1.3e-25 PREDICTED: transient receptor potential cation channel protein painless [Plutella xylostella]>gi|768438386|ref|XP_011560773.1| PREDICTED: transient receptor potential cation channel protein painless [Plutella xylostella] -- -- -- -- -- -- -- -- -- O90760 163 2.2e-09 Putative ankyrin repeat protein FPV031 OS=Fowlpox virus (strain NVSL) GN=ANK3 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28332 BF_2 334.28 4.25 3579 642918959 XP_008191673.1 1817 4.7e-200 PREDICTED: NEDD8 ultimate buster 1-like [Tribolium castaneum]>gi|270005608|gb|EFA02056.1| hypothetical protein TcasGA2_TC007685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54729 611 1.4e-61 NEDD8 ultimate buster 1 OS=Mus musculus GN=Nub1 PE=1 SV=2 PF13374//PF00240//PF17050//PF13414//PF03711 Tetratricopeptide repeat//Ubiquitin family//Altered inheritance of mitochondria 5//TPR repeat//Orn/Lys/Arg decarboxylase, C-terminal domain GO:0042407 cristae formation GO:0003824//GO:0005515 catalytic activity//protein binding GO:0061617//GO:0044284 MICOS complex//mitochondrial crista junction KOG2561 Adaptor protein NUB1, contains UBA domain Cluster-8309.28333 BF_2 25.00 8.38 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28334 BF_2 7.00 0.90 611 -- -- -- -- -- 359318420 JN968463.2 38 1.98811e-08 Dugesia japonica glucose-regulated protein 78 (grp78) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28335 BF_2 6.76 1.54 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28336 BF_2 209.94 2.06 4541 478251870 ENN72309.1 1219 1.3e-130 hypothetical protein YQE_11052, partial [Dendroctonus ponderosae] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 943 5.5e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF08241//PF08245//PF09445//PF14750//PF02875//PF02086 Methyltransferase domain//Mur ligase middle domain//RNA cap guanine-N2 methyltransferase//Integrator complex subunit 2//Mur ligase family, glutamate ligase domain//D12 class N6 adenine-specific DNA methyltransferase GO:0001510//GO:0009452//GO:0032775//GO:0008152//GO:0006306//GO:0009058 RNA methylation//7-methylguanosine RNA capping//DNA methylation on adenine//metabolic process//DNA methylation//biosynthetic process GO:0005524//GO:0016874//GO:0008168//GO:0009007 ATP binding//ligase activity//methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity GO:0032039 integrator complex KOG2525 Folylpolyglutamate synthase Cluster-8309.28337 BF_2 74.86 0.72 4621 478251870 ENN72309.1 1219 1.3e-130 hypothetical protein YQE_11052, partial [Dendroctonus ponderosae] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 943 5.6e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF08241//PF08245//PF14750//PF09445//PF02086//PF02875 Methyltransferase domain//Mur ligase middle domain//Integrator complex subunit 2//RNA cap guanine-N2 methyltransferase//D12 class N6 adenine-specific DNA methyltransferase//Mur ligase family, glutamate ligase domain GO:0008152//GO:0032775//GO:0009452//GO:0001510//GO:0009058//GO:0006306 metabolic process//DNA methylation on adenine//7-methylguanosine RNA capping//RNA methylation//biosynthetic process//DNA methylation GO:0016874//GO:0005524//GO:0009007//GO:0008168 ligase activity//ATP binding//site-specific DNA-methyltransferase (adenine-specific) activity//methyltransferase activity GO:0032039 integrator complex KOG2525 Folylpolyglutamate synthase Cluster-8309.28338 BF_2 81.47 0.50 7076 349584988 BAL03254.1 992 4.3e-104 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P80229 426 7.6e-40 Leukocyte elastase inhibitor OS=Sus scrofa GN=SERPINB1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28342 BF_2 149.00 4.83 1578 642926531 XP_008194908.1 868 2.3e-90 PREDICTED: facilitated trehalose transporter Tret1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z8N1 403 7.8e-38 Facilitated trehalose transporter Tret1-1 OS=Drosophila melanogaster GN=Tret1-1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28345 BF_2 13.07 0.74 1023 546674012 ERL85505.1 1218 3.9e-131 hypothetical protein D910_02924 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q961G1 865 1.4e-91 Conserved oligomeric Golgi complex subunit 3 OS=Drosophila melanogaster GN=Cog3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2604 Subunit of cis-Golgi transport vesicle tethering complex - Sec34p Cluster-8309.28346 BF_2 1182.26 8.02 6455 546682046 ERL92032.1 1889 3.8e-208 hypothetical protein D910_09354, partial [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.29464e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.8e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF00400//PF01435//PF03650//PF06784//PF03598//PF12317 WD domain, G-beta repeat//Peptidase family M48//Uncharacterised protein family (UPF0041)//Uncharacterised protein family (UPF0240)//CO dehydrogenase/acetyl-CoA synthase complex beta subunit//Intraflagellar transport complex B protein 46 C terminal GO:0006508//GO:0032981//GO:0042073//GO:0015947//GO:0006084//GO:0006850 proteolysis//mitochondrial respiratory chain complex I assembly//intraciliary transport//methane metabolic process//acetyl-CoA metabolic process//mitochondrial pyruvate transport GO:0018492//GO:0004222//GO:0005515 carbon-monoxide dehydrogenase (acceptor) activity//metalloendopeptidase activity//protein binding GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.28349 BF_2 149.48 1.02 6396 478255559 ENN75776.1 1889 3.8e-208 hypothetical protein YQE_07733, partial [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.24597e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.8e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF06784//PF12317//PF03598//PF00400//PF03650//PF01435 Uncharacterised protein family (UPF0240)//Intraflagellar transport complex B protein 46 C terminal//CO dehydrogenase/acetyl-CoA synthase complex beta subunit//WD domain, G-beta repeat//Uncharacterised protein family (UPF0041)//Peptidase family M48 GO:0006084//GO:0015947//GO:0006850//GO:0032981//GO:0006508//GO:0042073 acetyl-CoA metabolic process//methane metabolic process//mitochondrial pyruvate transport//mitochondrial respiratory chain complex I assembly//proteolysis//intraciliary transport GO:0004222//GO:0005515//GO:0018492 metalloendopeptidase activity//protein binding//carbon-monoxide dehydrogenase (acceptor) activity GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.28351 BF_2 419.56 7.00 2794 642914462 XP_008201687.1 952 7.4e-100 PREDICTED: potassium channel subfamily K member 6-like isoform X1 [Tribolium castaneum]>gi|270001497|gb|EEZ97944.1| hypothetical protein TcasGA2_TC000334 [Tribolium castaneum] -- -- -- -- -- K04912 KCNK1 potassium channel subfamily K member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04912 O00180 470 2.4e-45 Potassium channel subfamily K member 1 OS=Homo sapiens GN=KCNK1 PE=1 SV=1 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.28352 BF_2 2.00 0.71 404 91094043 XP_968570.1 145 4.0e-07 PREDICTED: peroxidasin [Tribolium castaneum]>gi|270004795|gb|EFA01243.1| peroxidasin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0055114//GO:0006804//GO:0006979 oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress GO:0020037//GO:0004601 heme binding//peroxidase activity -- -- -- -- Cluster-8309.28353 BF_2 10.01 0.48 1164 642914151 XP_008201566.1 657 5.0e-66 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 O35099 157 1.9e-09 Mitogen-activated protein kinase kinase kinase 5 OS=Mus musculus GN=Map3k5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28355 BF_2 212.92 0.77 11906 642937629 XP_008198876.1 4353 0.0e+00 PREDICTED: tubby-related protein 4 [Tribolium castaneum] 462288762 APGK01055065.1 72 5.13775e-26 Dendroctonus ponderosae Seq01055075, whole genome shotgun sequence -- -- -- -- Q9JIL5 1348 1.6e-146 Tubby-related protein 4 OS=Mus musculus GN=Tulp4 PE=2 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.28358 BF_2 2.00 3.65 289 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.2836 BF_2 38.47 0.59 3027 642927347 XP_008195231.1 726 1.3e-73 PREDICTED: uncharacterized protein C1orf112 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NSG2 157 5.0e-09 Uncharacterized protein C1orf112 OS=Homo sapiens GN=C1orf112 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28360 BF_2 7.00 1.85 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28361 BF_2 2.00 5.61 272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28364 BF_2 112.88 8.73 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF06784 Zinc-finger associated domain (zf-AD)//Uncharacterised protein family (UPF0240) GO:0032981 mitochondrial respiratory chain complex I assembly GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28367 BF_2 12.28 0.46 1399 642930375 XP_008196372.1 617 2.6e-61 PREDICTED: myosin-2 essential light chain isoform X1 [Tribolium castaneum] 389608774 AK401377.1 83 4.53502e-33 Papilio xuthus mRNA for myosin light chain cytoplasmic, complete cds, sequence id: Px-0488 K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 P54357 466 3.4e-45 Myosin-2 essential light chain OS=Drosophila melanogaster GN=Mlc-c PE=1 SV=1 PF13202//PF13833//PF13405//PF00036//PF13499 EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.28368 BF_2 567.05 12.40 2200 160333785 NP_001103903.1 2227 8.3e-248 chitin deacetylase 4 precursor [Tribolium castaneum]>gi|158562480|gb|ABW74146.1| chitin deacetylase 4 [Tribolium castaneum]>gi|270005565|gb|EFA02013.1| hypothetical protein TcasGA2_TC007635 [Tribolium castaneum] 645033089 XM_001607939.3 188 3.07641e-91 PREDICTED: Nasonia vitripennis uncharacterized LOC100123586 (LOC100123586), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0005975//GO:0006807//GO:0006030 carbohydrate metabolic process//nitrogen compound metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.28369 BF_2 1.00 14.52 224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28370 BF_2 43.67 6.07 588 546685505 ERL95003.1 282 7.6e-23 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836 RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.28371 BF_2 108.33 15.96 571 546685505 ERL95003.1 252 2.2e-19 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836 RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.28372 BF_2 116.00 11.24 719 546685504 ERL95002.1 335 6.7e-29 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03836 RasGAP C-terminus GO:0007264 small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.28374 BF_2 60.47 0.55 4926 642912875 XP_008201292.1 4481 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1049 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1713 3.1e-189 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00781//PF00076//PF00130//PF00788//PF00609//PF07649 Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase accessory domain//C1-like domain GO:0046486//GO:0035556//GO:0055114//GO:0007205//GO:0009395//GO:0007165 glycerolipid metabolic process//intracellular signal transduction//oxidation-reduction process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//signal transduction GO:0003676//GO:0016301//GO:0000166//GO:0047134//GO:0046872//GO:0004143 nucleic acid binding//kinase activity//nucleotide binding//protein-disulfide reductase activity//metal ion binding//diacylglycerol kinase activity GO:0005622 intracellular KOG1169 Diacylglycerol kinase Cluster-8309.28375 BF_2 262.67 3.52 3412 91082935 XP_973029.1 2245 1.1e-249 PREDICTED: probable G-protein coupled receptor 158 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BBQ2 593 1.6e-59 Probable G-protein coupled receptor 158 OS=Bos taurus GN=GPR158 PE=3 SV=2 PF03188//PF11057//PF00003//PF06070//PF02780 Eukaryotic cytochrome b561//Cortexin of kidney//7 transmembrane sweet-taste receptor of 3 GCPR//Herpesvirus large structural phosphoprotein UL32//Transketolase, C-terminal domain GO:0007186//GO:0008152 G-protein coupled receptor signaling pathway//metabolic process GO:0003824//GO:0004930//GO:0005198 catalytic activity//G-protein coupled receptor activity//structural molecule activity GO:0016021//GO:0031224 integral component of membrane//intrinsic component of membrane KOG4418 Predicted membrane protein Cluster-8309.28376 BF_2 4.58 1.14 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28378 BF_2 26.00 1.06 1316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28379 BF_2 1.00 0.90 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28381 BF_2 70.88 0.66 4776 642928567 XP_008199961.1 759 3.0e-77 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 580 7.1e-58 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067//PF09520//PF05316 Cytochrome P450//Type II restriction endonuclease, TdeIII//Mitochondrial ribosomal protein (VAR1) GO:0006412//GO:0055114//GO:0006308//GO:0042254//GO:0009307 translation//oxidation-reduction process//DNA catabolic process//ribosome biogenesis//DNA restriction-modification system GO:0016705//GO:0003677//GO:0009036//GO:0020037//GO:0005506//GO:0003735 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//DNA binding//Type II site-specific deoxyribonuclease activity//heme binding//iron ion binding//structural constituent of ribosome GO:0009359//GO:0005840//GO:0005761 Type II site-specific deoxyribonuclease complex//ribosome//mitochondrial ribosome -- -- Cluster-8309.28383 BF_2 17.53 0.66 1406 642928567 XP_008199961.1 796 4.6e-82 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 531 1.0e-52 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.28385 BF_2 45.00 3.48 828 642927254 XP_008195196.1 383 2.1e-34 PREDICTED: protein ACN9 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SZ16 295 1.4e-25 Succinate dehydrogenase assembly factor 3, mitochondrial OS=Drosophila melanogaster GN=Sdhaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4100 Uncharacterized conserved protein Cluster-8309.28386 BF_2 40.69 2.38 1002 288860140 NP_001165842.1 638 6.8e-64 uracil-DNA degrading factor [Tribolium castaneum]>gi|270002992|gb|EEZ99439.1| hypothetical protein TcasGA2_TC030651 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28387 BF_2 13.00 0.49 1399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28389 BF_2 3.00 0.41 591 724798404 XP_010364899.1 158 1.8e-08 PREDICTED: sorting nexin-6 isoform X2 [Rhinopithecus roxellana] -- -- -- -- -- -- -- -- -- Q9UNH7 145 2.4e-08 Sorting nexin-6 OS=Homo sapiens GN=SNX6 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.28391 BF_2 40.87 0.40 4597 91092640 XP_969145.1 2776 3.6e-311 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1131 8.8e-122 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 -- -- -- -- GO:0043169 cation binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.28394 BF_2 219.18 0.90 10524 91088841 XP_970807.1 2162 1.4e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.65015e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 6.1e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF01853//PF00538//PF00628//PF13508//PF01160//PF06431 MOZ/SAS family//linker histone H1 and H5 family//PHD-finger//Acetyltransferase (GNAT) domain//Vertebrate endogenous opioids neuropeptide//Polyomavirus large T antigen C-terminus GO:0042967//GO:0006334//GO:0006260//GO:0007218//GO:0006355 acyl-carrier-protein biosynthetic process//nucleosome assembly//DNA replication//neuropeptide signaling pathway//regulation of transcription, DNA-templated GO:0005515//GO:0008080//GO:0003677//GO:0005524//GO:0016747//GO:0005488 protein binding//N-acetyltransferase activity//DNA binding//ATP binding//transferase activity, transferring acyl groups other than amino-acyl groups//binding GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.28396 BF_2 71.00 2.30 1579 195470156 XP_002087374.1 190 9.5e-12 GE16582 [Drosophila yakuba]>gi|194173475|gb|EDW87086.1| GE16582 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- P18298 145 6.5e-08 S-adenosylmethionine synthase isoform type-2 OS=Rattus norvegicus GN=Mat2a PE=1 SV=1 -- -- GO:0006556//GO:0006730//GO:0015948//GO:0006555 S-adenosylmethionine biosynthetic process//one-carbon metabolic process//methanogenesis//methionine metabolic process GO:0004478//GO:0005524//GO:0046872 methionine adenosyltransferase activity//ATP binding//metal ion binding -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8309.28397 BF_2 258.97 4.33 2787 642926864 XP_008195044.1 2346 1.7e-261 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum] 748585115 LC002996.1 39 2.63381e-08 Ostrinia furnacalis gene for hypothetical protein, partial cds, note: entry16 -- -- -- -- O18824 615 3.6e-62 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.28398 BF_2 17.00 5.93 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.284 BF_2 19.95 0.63 1608 642925556 XP_971635.2 488 2.7e-46 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75897 274 7.3e-23 Sulfotransferase 1C4 OS=Homo sapiens GN=SULT1C4 PE=1 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.28400 BF_2 67.00 1.42 2266 270006529 EFA02977.1 1090 6.0e-116 hypothetical protein TcasGA2_TC030780 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O77649 291 1.1e-24 UDP-glucuronosyltransferase 2B20 OS=Macaca fascicularis GN=UGT2B20 PE=1 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.28401 BF_2 74.89 0.48 6824 546681968 ERL91964.1 676 1.8e-67 hypothetical protein D910_09287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 139 1.4e-06 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF09472//PF04838 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Baculoviridae late expression factor 5 GO:0046656//GO:0015948//GO:0006355 folic acid biosynthetic process//methanogenesis//regulation of transcription, DNA-templated GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.28403 BF_2 236.95 3.63 3021 270014969 EFA11417.1 3432 0.0e+00 hypothetical protein TcasGA2_TC013593 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1262 3.7e-137 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF00103//PF08123//PF02390 Somatotropin hormone family//Histone methylation protein DOT1//Putative methyltransferase GO:0007165//GO:0009451//GO:0006479//GO:0006400//GO:0008033//GO:0006554 signal transduction//RNA modification//protein methylation//tRNA modification//tRNA processing//lysine catabolic process GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.28404 BF_2 227.00 18.48 801 642917175 XP_008191150.1 821 3.3e-85 PREDICTED: pangolin isoform X2 [Tribolium castaneum] 642917174 XM_008192928.1 309 5.94277e-159 PREDICTED: Tribolium castaneum pangolin (Pan), transcript variant X2, mRNA K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 P91943 438 3.5e-42 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28406 BF_2 48.15 0.45 4719 642932794 XP_974082.2 1528 2.0e-166 PREDICTED: dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [Tribolium castaneum] 755973707 XM_011308799.1 131 3.22924e-59 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 1129 1.5e-121 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF04196//PF00069//PF07714 Bunyavirus RNA dependent RNA polymerase//Protein kinase domain//Protein tyrosine kinase GO:0006351//GO:0019079//GO:0006468//GO:0006144 transcription, DNA-templated//viral genome replication//protein phosphorylation//purine nucleobase metabolic process GO:0005524//GO:0003968//GO:0004672 ATP binding//RNA-directed RNA polymerase activity//protein kinase activity GO:0031379 RNA-directed RNA polymerase complex KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4 Cluster-8309.28407 BF_2 560.17 7.52 3405 91078826 XP_971080.1 2362 2.9e-263 PREDICTED: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [Tribolium castaneum]>gi|270003721|gb|EFA00169.1| hypothetical protein TcasGA2_TC002991 [Tribolium castaneum] 347970839 XM_308110.5 56 1.14379e-17 Anopheles gambiae str. PEST AGAP003884-PA (AgaP_AGAP003884) mRNA, complete cds K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 Q9UKM7 1389 7.9e-152 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Homo sapiens GN=MAN1B1 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2431 1, 2-alpha-mannosidase Cluster-8309.28408 BF_2 105.00 8.20 823 332376336 AEE63308.1 495 2.1e-47 unknown [Dendroctonus ponderosae]>gi|478250761|gb|ENN71253.1| hypothetical protein YQE_12180, partial [Dendroctonus ponderosae]>gi|546671401|gb|ERL83726.1| hypothetical protein D910_00939 [Dendroctonus ponderosae]>gi|546673039|gb|ERL84725.1| hypothetical protein D910_02150 [Dendroctonus ponderosae]>gi|546675545|gb|ERL86718.1| hypothetical protein D910_04124 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y6G5 212 5.7e-16 COMM domain-containing protein 10 OS=Homo sapiens GN=COMMD10 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28409 BF_2 21.00 0.87 1299 123445779 XP_001311646.1 205 1.4e-13 hypothetical protein [Trichomonas vaginalis G3]>gi|121893464|gb|EAX98716.1| hypothetical protein TVAG_480920 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54J55 170 6.7e-11 Myb-like protein X OS=Dictyostelium discoideum GN=mybX PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28415 BF_2 74.00 2.22 1681 478251541 ENN72003.1 878 1.7e-91 hypothetical protein YQE_11294, partial [Dendroctonus ponderosae]>gi|546681207|gb|ERL91342.1| hypothetical protein D910_08674 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q98943 360 8.1e-33 Caspase-2 OS=Gallus gallus GN=CASP2 PE=2 SV=2 PF00656//PF02735//PF00619 Caspase domain//Ku70/Ku80 beta-barrel domain//Caspase recruitment domain GO:0006303//GO:0042981//GO:0006508 double-strand break repair via nonhomologous end joining//regulation of apoptotic process//proteolysis GO:0004197//GO:0003677 cysteine-type endopeptidase activity//DNA binding -- -- KOG3573 Caspase, apoptotic cysteine protease Cluster-8309.28417 BF_2 3766.70 24.58 6698 642934517 XP_008197696.1 5483 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X1 [Tribolium castaneum]>gi|270013510|gb|EFA09958.1| hypothetical protein TcasGA2_TC012115 [Tribolium castaneum] 815926192 XM_012392264.1 601 0 PREDICTED: Bombus impatiens chromodomain-helicase-DNA-binding protein Mi-2 homolog (LOC100740721), transcript variant X10, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 4696 0.0e+00 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF08074//PF00270//PF04851//PF00641//PF00176//PF08073//PF00130//PF00628//PF00001//PF06357 CHDCT2 (NUC038) domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Zn-finger in Ran binding protein and others//SNF2 family N-terminal domain//CHDNT (NUC034) domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//7 transmembrane receptor (rhodopsin family)//Omega-atracotoxin GO:0006952//GO:0006810//GO:0009405//GO:0035556//GO:0006355//GO:0007186 defense response//transport//pathogenesis//intracellular signal transduction//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway GO:0005524//GO:0016787//GO:0019855//GO:0016818//GO:0008270//GO:0005515//GO:0004386//GO:0004930//GO:0003677//GO:0043169//GO:0003676 ATP binding//hydrolase activity//calcium channel inhibitor activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//protein binding//helicase activity//G-protein coupled receptor activity//DNA binding//cation binding//nucleic acid binding GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG0383 Predicted helicase Cluster-8309.28420 BF_2 474.00 12.20 1913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02740 Colipase, C-terminal domain GO:0016042//GO:0007586 lipid catabolic process//digestion GO:0008047 enzyme activator activity GO:0005576 extracellular region -- -- Cluster-8309.28421 BF_2 7.09 0.37 1100 478253832 ENN74124.1 234 5.2e-17 hypothetical protein YQE_09097, partial [Dendroctonus ponderosae]>gi|546684638|gb|ERL94255.1| hypothetical protein D910_11536 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28423 BF_2 271.65 15.68 1012 189235321 XP_975176.2 857 2.8e-89 PREDICTED: methyltransferase-like protein 22 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUU2 221 6.4e-17 Methyltransferase-like protein 22 OS=Homo sapiens GN=METTL22 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28426 BF_2 584.52 16.74 1748 642914052 XP_969243.3 1720 4.1e-189 PREDICTED: sorting nexin-6 isoform X2 [Tribolium castaneum]>gi|270001606|gb|EEZ98053.1| hypothetical protein TcasGA2_TC000458 [Tribolium castaneum] 697469095 XM_009669926.1 81 7.36744e-32 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 1053 3.7e-113 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF04632//PF00787 Fusaric acid resistance protein family//PX domain GO:0007154//GO:0006810 cell communication//transport GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.28428 BF_2 142.46 3.57 1955 189237918 XP_001811805.1 2173 1.3e-241 PREDICTED: transcription initiation factor TFIID subunit 6 [Tribolium castaneum]>gi|270006675|gb|EFA03123.1| hypothetical protein TcasGA2_TC013033 [Tribolium castaneum] 762091727 XM_011429969.1 66 1.80017e-23 PREDICTED: Crassostrea gigas transcription initiation factor TFIID subunit 6-like (LOC105328924), mRNA K03131 TAF6 transcription initiation factor TFIID subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03131 P49847 1567 1.0e-172 Transcription initiation factor TFIID subunit 6 OS=Drosophila melanogaster GN=Taf6 PE=1 SV=2 PF02969//PF07571//PF08769//PF00125 TATA box binding protein associated factor (TAF)//TAF6 C-terminal HEAT repeat domain//Sporulation initiation factor Spo0A C terminal//Core histone H2A/H2B/H3/H4 GO:0006355//GO:0042173//GO:0006352//GO:0051090 regulation of transcription, DNA-templated//regulation of sporulation resulting in formation of a cellular spore//DNA-templated transcription, initiation//regulation of sequence-specific DNA binding transcription factor activity GO:0005509//GO:0003700//GO:0003677//GO:0046982 calcium ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding//protein heterodimerization activity GO:0005737//GO:0005634//GO:0005667 cytoplasm//nucleus//transcription factor complex KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.28429 BF_2 18.31 1.04 1024 546681137 ERL91287.1 264 1.6e-20 hypothetical protein D910_08620 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28430 BF_2 3.00 0.40 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28432 BF_2 21.89 0.31 3205 91081871 XP_968443.1 1004 7.9e-106 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q9UL12 746 2.7e-77 Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1 PF01494//PF07992//PF11501//PF12831//PF01266//PF13241//PF05834//PF02558//PF01134//PF00070 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Non structural protein Nsp1//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Lycopene cyclase protein//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase GO:0016117//GO:0006508//GO:0019354//GO:0055114//GO:0006779//GO:0008033//GO:0015940 carotenoid biosynthetic process//proteolysis//siroheme biosynthetic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//tRNA processing//pantothenate biosynthetic process GO:0004197//GO:0016817//GO:0050660//GO:0008677//GO:0016491//GO:0016788//GO:0016705//GO:0008242//GO:0043115//GO:0071949//GO:0016740 cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity//hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//omega peptidase activity//precorrin-2 dehydrogenase activity//FAD binding//transferase activity -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.28433 BF_2 208.06 15.04 866 642912857 XP_008201282.1 795 3.7e-82 PREDICTED: AP-1 complex subunit sigma-2 isoform X2 [Tribolium castaneum] 642912856 XM_008203060.1 207 3.24194e-102 PREDICTED: Tribolium castaneum AP-1 complex subunit sigma-2 (LOC659702), transcript variant X2, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 Q3ZBS3 673 2.1e-69 AP-1 complex subunit sigma-2 OS=Bos taurus GN=AP1S2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.28435 BF_2 13.00 0.73 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28436 BF_2 3.00 0.35 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28437 BF_2 619.75 12.47 2366 189235165 XP_968097.2 1371 1.6e-148 PREDICTED: RNA polymerase-associated protein Rtf1 [Tribolium castaneum] -- -- -- -- -- K15178 RTF1 RNA polymerase-associated protein RTF1 http://www.genome.jp/dbget-bin/www_bget?ko:K15178 Q9W261 946 1.3e-100 RNA polymerase-associated protein Rtf1 OS=Drosophila melanogaster GN=Rtf1 PE=1 SV=1 PF03126 Plus-3 domain -- -- GO:0003677 DNA binding -- -- KOG2402 Paf1/RNA polymerase II complex, RTF1 component (involved in regulation of TATA box-binding protein) Cluster-8309.28438 BF_2 1.00 1.56 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28439 BF_2 247.13 3.72 3065 91092584 XP_969806.1 1985 1.3e-219 PREDICTED: F-box only protein 42 [Tribolium castaneum] 642921791 XM_964713.2 183 2.58961e-88 PREDICTED: Tribolium castaneum F-box only protein 42 (LOC658311), mRNA K10317 FBXO42 F-box protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K10317 Q6PDJ6 755 2.3e-78 F-box only protein 42 OS=Mus musculus GN=Fbxo42 PE=2 SV=1 PF12937//PF01344//PF07646//PF00646 F-box-like//Kelch motif//Kelch motif//F-box domain -- -- GO:0005515 protein binding -- -- KOG0379 Kelch repeat-containing proteins Cluster-8309.28441 BF_2 385.02 7.52 2429 189236145 XP_974763.2 2325 4.0e-259 PREDICTED: diphthine--ammonia ligase [Tribolium castaneum]>gi|270005602|gb|EFA02050.1| hypothetical protein TcasGA2_TC007678 [Tribolium castaneum] -- -- -- -- -- K06927 DPH6 diphthine-ammonia ligase http://www.genome.jp/dbget-bin/www_bget?ko:K06927 Q9USQ7 917 3.0e-97 Diphthine--ammonia ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mug71 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2316 Predicted ATPase (PP-loop superfamily) Cluster-8309.28444 BF_2 22.44 0.82 1438 642929416 XP_008195830.1 398 6.6e-36 PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929418|ref|XP_008195831.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929420|ref|XP_008195832.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI6 267 4.2e-22 Transcription factor CP2-like protein 1 OS=Homo sapiens GN=TFCP2L1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.28446 BF_2 69.00 3.56 1098 91077690 XP_974728.1 1017 8.4e-108 PREDICTED: transcriptional adapter 1 [Tribolium castaneum]>gi|270001530|gb|EEZ97977.1| hypothetical protein TcasGA2_TC000372 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99LM9 254 1.0e-20 Transcriptional adapter 1 OS=Mus musculus GN=Tada1 PE=2 SV=1 PF12767//PF05236 Transcriptional regulator of RNA polII, SAGA, subunit//Transcription initiation factor TFIID component TAF4 family GO:0006352 DNA-templated transcription, initiation -- -- GO:0070461//GO:0005669 SAGA-type complex//transcription factor TFIID complex -- -- Cluster-8309.28447 BF_2 120.00 3.43 1750 642918336 XP_008196857.1 262 4.7e-20 PREDICTED: serine/threonine-protein kinase tricorner [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28449 BF_2 85.64 2.36 1802 478254833 ENN75069.1 881 8.1e-92 hypothetical protein YQE_08382, partial [Dendroctonus ponderosae] -- -- -- -- -- K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P85973 738 1.3e-76 Purine nucleoside phosphorylase OS=Rattus norvegicus GN=Pnp PE=1 SV=1 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.28452 BF_2 77.97 0.80 4349 270011364 EFA07812.1 378 4.2e-33 hypothetical protein TcasGA2_TC005373 [Tribolium castaneum] -- -- -- -- -- K12811 DDX46, PRP5 ATP-dependent RNA helicase DDX46/PRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K12811 Q7L014 269 7.5e-22 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens GN=DDX46 PE=1 SV=2 PF12179 I-kappa-kinase-beta NEMO binding domain GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0008384 IkappaB kinase activity GO:0008385 IkappaB kinase complex KOG0334 RNA helicase Cluster-8309.28453 BF_2 225.02 1.47 6709 270001519 EEZ97966.1 3745 0.0e+00 hypothetical protein TcasGA2_TC000358 [Tribolium castaneum] 462381540 APGK01021978.1 59 4.86715e-19 Dendroctonus ponderosae Seq01021988, whole genome shotgun sequence K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 1088 1.2e-116 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF04111//PF10473//PF16331//PF11365 Autophagy protein Apg6//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TolA binding protein trimerisation//Protein of unknown function (DUF3166) GO:0006914//GO:0070206//GO:0010506 autophagy//protein trimerization//regulation of autophagy GO:0042803//GO:0045502//GO:0008134 protein homodimerization activity//dynein binding//transcription factor binding GO:0005615//GO:0005667//GO:0030286 extracellular space//transcription factor complex//dynein complex -- -- Cluster-8309.28456 BF_2 13.00 2.00 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28457 BF_2 247.00 46.76 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28461 BF_2 9.14 0.40 1233 642938308 XP_008192812.1 431 8.4e-40 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X4 [Tribolium castaneum] 642938313 XM_008194605.1 103 3.03587e-44 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X8, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28462 BF_2 546.26 2.70 8741 270014238 EFA10686.1 640 3.5e-63 Syntaxin 1A [Tribolium castaneum] 820846584 XM_012485784.1 129 7.76162e-58 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X4, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 565 7.1e-56 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF15898//PF04136//PF04799//PF01499//PF09003//PF05739//PF09177//PF00804//PF11744//PF00443//PF04632//PF05478//PF02485//PF07851//PF04111 cGMP-dependent protein kinase interacting domain//Sec34-like family//fzo-like conserved region//Herpesvirus UL25 family//Bacteriophage lambda integrase, N-terminal domain//SNARE domain//Syntaxin 6, N-terminal//Syntaxin//Aluminium activated malate transporter//Ubiquitin carboxyl-terminal hydrolase//Fusaric acid resistance protein family//Prominin//Core-2/I-Branching enzyme//TMPIT-like protein//Autophagy protein Apg6 GO:0006886//GO:0006810//GO:0006914//GO:0019072//GO:0016579//GO:0048193//GO:0015743//GO:0015074//GO:0008053 intracellular protein transport//transport//autophagy//viral genome packaging//protein deubiquitination//Golgi vesicle transport//malate transport//DNA integration//mitochondrial fusion GO:0003924//GO:0008375//GO:0036459//GO:0019901//GO:0005515//GO:0003677//GO:0008907 GTPase activity//acetylglucosaminyltransferase activity//ubiquitinyl hydrolase activity//protein kinase binding//protein binding//DNA binding//integrase activity GO:0042025//GO:0016021//GO:0005801//GO:0005886//GO:0016020//GO:0005741 host cell nucleus//integral component of membrane//cis-Golgi network//plasma membrane//membrane//mitochondrial outer membrane KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.28463 BF_2 15.99 0.97 976 270010211 EFA06659.1 300 1.0e-24 hypothetical protein TcasGA2_TC009585 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28464 BF_2 114.36 0.74 6760 642916006 XP_008190854.1 2795 0.0e+00 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96923 134 5.2e-06 Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum GN=gnrA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28467 BF_2 11.93 0.33 1794 91079210 XP_966588.1 978 4.6e-103 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [Tribolium castaneum]>gi|270004834|gb|EFA01282.1| hypothetical protein TcasGA2_TC002817 [Tribolium castaneum] 699239055 XM_002131725.3 75 1.6376e-28 PREDICTED: Ciona intestinalis NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (LOC100183052), mRNA K03936 NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03936 P23709 791 9.1e-83 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Bos taurus GN=NDUFS3 PE=1 SV=1 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit GO:0006814//GO:0006120//GO:0006744//GO:0015992//GO:0055114 sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//proton transport//oxidation-reduction process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG1713 NADH-ubiquinone oxidoreductase, NDUFS3/30 kDa subunit Cluster-8309.28469 BF_2 373.22 9.45 1940 270003897 EFA00345.1 2375 5.1e-265 hypothetical protein TcasGA2_TC003184 [Tribolium castaneum] 766920220 XM_011506269.1 107 2.88492e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1725 4.9e-191 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF00270//PF00437//PF03060//PF03368 DEAD/DEAH box helicase//Type II/IV secretion system protein//Nitronate monooxygenase//Dicer dimerisation domain GO:0006810//GO:0006807//GO:0055114//GO:0051252 transport//nitrogen compound metabolic process//oxidation-reduction process//regulation of RNA metabolic process GO:0018580//GO:0005524//GO:0016891//GO:0003676 nitronate monooxygenase activity//ATP binding//endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.28471 BF_2 387.91 5.47 3255 91082551 XP_973940.1 2212 6.8e-246 PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|642922810|ref|XP_008193334.1| PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|642922812|ref|XP_008193335.1| PREDICTED: putative tyrosine-protein kinase Wsck [Tribolium castaneum]>gi|270007563|gb|EFA04011.1| hypothetical protein TcasGA2_TC014160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83097 782 1.8e-81 Putative tyrosine-protein kinase Wsck OS=Drosophila melanogaster GN=Wsck PE=2 SV=2 PF00069//PF07714//PF00041 Protein kinase domain//Protein tyrosine kinase//Fibronectin type III domain GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.28472 BF_2 213.36 0.80 11384 642923391 XP_008193728.1 8407 0.0e+00 PREDICTED: protein still life, isoform SIF type 1 [Tribolium castaneum] 642923390 XM_008195506.1 1824 0 PREDICTED: Tribolium castaneum protein still life, isoform SIF type 1 (LOC662876), mRNA -- -- -- -- P91621 6459 0.0e+00 Protein still life, isoform SIF type 1 OS=Drosophila melanogaster GN=sif PE=2 SV=2 PF00595//PF00621//PF02724//PF13180//PF02196//PF05453 PDZ domain (Also known as DHR or GLGF)//RhoGEF domain//CDC45-like protein//PDZ domain//Raf-like Ras-binding domain//BmTXKS1/BmP02 toxin family GO:0035023//GO:0007165//GO:0009405//GO:0006270//GO:0006810//GO:0043087 regulation of Rho protein signal transduction//signal transduction//pathogenesis//DNA replication initiation//transport//regulation of GTPase activity GO:0008200//GO:0005057//GO:0005515//GO:0005089 ion channel inhibitor activity//receptor signaling protein activity//protein binding//Rho guanyl-nucleotide exchange factor activity GO:0005576 extracellular region KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases Cluster-8309.28476 BF_2 1029.91 14.21 3320 91085411 XP_967521.1 2312 1.7e-257 PREDICTED: protein Malvolio isoform X1 [Tribolium castaneum]>gi|270008404|gb|EFA04852.1| hypothetical protein TcasGA2_TC014904 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.8e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF08089//PF15168//PF01566 Huwentoxin-II family//Triple QxxK/R motif-containing protein family//Natural resistance-associated macrophage protein GO:0009405//GO:0006810 pathogenesis//transport GO:0005215 transporter activity GO:0005789//GO:0016020//GO:0005576 endoplasmic reticulum membrane//membrane//extracellular region KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.28478 BF_2 11.00 0.60 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28480 BF_2 39.23 0.78 2402 478264640 ENN82297.1 626 4.0e-62 hypothetical protein YQE_01327, partial [Dendroctonus ponderosae] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 299 1.4e-25 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553//PF02563 Acyltransferase//Polysaccharide biosynthesis/export protein GO:0015774//GO:0008152 polysaccharide transport//metabolic process GO:0016746//GO:0015159 transferase activity, transferring acyl groups//polysaccharide transmembrane transporter activity GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.28481 BF_2 58.51 2.19 1404 642937410 XP_008198824.1 862 1.0e-89 PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|642937412|ref|XP_008198826.1| PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|270000810|gb|EEZ97257.1| hypothetical protein TcasGA2_TC011057 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 380 3.2e-35 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152//GO:0008654//GO:0046486//GO:0042967 metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.28482 BF_2 445.16 33.56 842 642923289 XP_008193692.1 459 3.3e-43 PREDICTED: uncharacterized protein LOC103313098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28484 BF_2 11.00 2.17 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28486 BF_2 61.77 3.56 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28487 BF_2 275.06 5.60 2341 642924686 XP_008194398.1 2217 1.3e-246 PREDICTED: mitochondrial sodium/hydrogen exchanger 9B2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UD5 734 4.8e-76 Mitochondrial sodium/hydrogen exchanger 9B2 OS=Homo sapiens GN=SLC9B2 PE=1 SV=2 PF00999//PF07086 Sodium/hydrogen exchanger family//Jagunal, ER re-organisation during oogenesis GO:0006885//GO:0055085//GO:0006812//GO:0007029 regulation of pH//transmembrane transport//cation transport//endoplasmic reticulum organization GO:0015299 solute:proton antiporter activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3826 Na+/H+ antiporter Cluster-8309.28489 BF_2 613.48 26.09 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28491 BF_2 5.05 0.79 556 546684786 ERL94381.1 354 3.2e-31 hypothetical protein D910_11660 [Dendroctonus ponderosae] 414073107 JQ885989.1 96 1.03018e-40 Misgurnus anguillicaudatus HSC70 mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 350 3.9e-32 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.28493 BF_2 63.89 7.29 654 189241548 XP_971070.2 353 4.9e-31 PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|642936933|ref|XP_008194513.1| PREDICTED: GA-binding protein subunit beta-1 [Tribolium castaneum]>gi|270001278|gb|EEZ97725.1| spatzle 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28495 BF_2 67.85 2.42 1459 642918268 XP_008191439.1 1176 4.1e-126 PREDICTED: methoprene-tolerant isoform X1 [Tribolium castaneum]>gi|207367000|dbj|BAG71980.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97460 221 9.2e-17 Neuronal PAS domain-containing protein 2 OS=Mus musculus GN=Npas2 PE=1 SV=1 PF00989//PF08447 PAS fold//PAS fold GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0046983//GO:0004871//GO:0003700 DNA binding//protein binding//protein dimerization activity//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.28496 BF_2 70.92 1.11 2953 642914975 XP_008190466.1 1090 7.8e-116 PREDICTED: sialic acid synthase [Tribolium castaneum]>gi|270001379|gb|EEZ97826.1| hypothetical protein TcasGA2_TC000193 [Tribolium castaneum] -- -- -- -- -- K05304 NANS, SAS sialic acid synthase http://www.genome.jp/dbget-bin/www_bget?ko:K05304 Q9NR45 957 8.5e-102 Sialic acid synthase OS=Homo sapiens GN=NANS PE=1 SV=2 PF03102//PF03998 NeuB family//Utp11 protein GO:0016051//GO:0006364 carbohydrate biosynthetic process//rRNA processing -- -- GO:0032040 small-subunit processome KOG3237 Uncharacterized conserved protein Cluster-8309.28497 BF_2 286.08 4.92 2722 642914975 XP_008190466.1 1090 7.2e-116 PREDICTED: sialic acid synthase [Tribolium castaneum]>gi|270001379|gb|EEZ97826.1| hypothetical protein TcasGA2_TC000193 [Tribolium castaneum] -- -- -- -- -- K05304 NANS, SAS sialic acid synthase http://www.genome.jp/dbget-bin/www_bget?ko:K05304 Q9NR45 957 7.8e-102 Sialic acid synthase OS=Homo sapiens GN=NANS PE=1 SV=2 PF03102//PF03998 NeuB family//Utp11 protein GO:0016051//GO:0006364 carbohydrate biosynthetic process//rRNA processing -- -- GO:0032040 small-subunit processome KOG3237 Uncharacterized conserved protein Cluster-8309.28498 BF_2 17.23 0.35 2360 478255545 ENN75762.1 1819 1.8e-200 hypothetical protein YQE_07721, partial [Dendroctonus ponderosae] 665793581 XM_008546222.1 67 6.06093e-24 PREDICTED: Microplitis demolitor proton-associated sugar transporter A-like (LOC103569108), mRNA K15378 SLC45A1_2_4 solute carrier family 45, member 1/2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15378 Q9UMX9 636 1.1e-64 Membrane-associated transporter protein OS=Homo sapiens GN=SLC45A2 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0637 Sucrose transporter and related proteins Cluster-8309.285 BF_2 17.16 0.53 1650 642925556 XP_971635.2 589 5.4e-58 PREDICTED: estrogen sulfotransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WUW9 347 2.6e-31 Sulfotransferase 1C2A OS=Rattus norvegicus GN=Sult1c2a PE=2 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.28500 BF_2 141.01 6.16 1245 642933391 XP_008197397.1 350 2.1e-30 PREDICTED: cyclin-dependent kinase 2-associated protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49119 216 3.0e-16 Cyclin-dependent kinase 2-associated protein 1 OS=Mesocricetus auratus GN=CDK2AP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4713 Cyclin-dependent kinase 2-associated protein Cluster-8309.28502 BF_2 23.95 0.57 2053 478256565 ENN76749.1 468 7.2e-44 hypothetical protein YQE_06814, partial [Dendroctonus ponderosae] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q4R4D5 335 7.8e-30 Glycerol kinase 2 OS=Macaca fascicularis GN=GK2 PE=2 SV=1 PF02782 FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.28505 BF_2 17.67 3.20 518 642938802 XP_008199892.1 355 2.3e-31 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- K09641 TMPRSS11D transmembrane protease, serine 11D http://www.genome.jp/dbget-bin/www_bget?ko:K09641 P05049 305 5.9e-27 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.28506 BF_2 636.00 7.08 4045 91086457 XP_969562.1 2035 2.8e-225 PREDICTED: vacuolar fusion protein MON1 homolog A [Tribolium castaneum]>gi|270009814|gb|EFA06262.1| hypothetical protein TcasGA2_TC009122 [Tribolium castaneum] 820858498 XM_003696673.2 207 1.56115e-101 PREDICTED: Apis florea pre-mRNA-splicing factor 38A (LOC100871075), mRNA -- -- -- -- Q5ZIH2 1009 1.1e-107 Vacuolar fusion protein MON1 homolog A OS=Gallus gallus GN=MON1A PE=2 SV=1 PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG0997 Uncharacterized conserved protein Sand Cluster-8309.28507 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28508 BF_2 29.14 0.33 3934 642937864 XP_008200330.1 2824 0.0e+00 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEP1 1762 5.1e-195 Protein FAM91A1 OS=Danio rerio GN=fam91a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.2851 BF_2 1.00 0.35 407 795056175 XP_011871767.1 189 3.2e-12 PREDICTED: uncharacterized protein LOC105564172 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28511 BF_2 91.46 1.69 2548 642931147 XP_008196461.1 1360 3.3e-147 PREDICTED: arginyl-tRNA--protein transferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00685 ATE1, ate1 arginine-tRNA-protein transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00685 Q9Z2A5 968 3.9e-103 Arginyl-tRNA--protein transferase 1 OS=Mus musculus GN=Ate1 PE=1 SV=2 PF04376//PF04377 Arginine-tRNA-protein transferase, N terminus//Arginine-tRNA-protein transferase, C terminus GO:0016598 protein arginylation GO:0004057 arginyltransferase activity -- -- KOG1193 Arginyl-tRNA-protein transferase Cluster-8309.28513 BF_2 89.86 1.92 2244 91088073 XP_968074.1 1399 8.7e-152 PREDICTED: arginyl-tRNA--protein transferase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00685 ATE1, ate1 arginine-tRNA-protein transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00685 Q9Z2A5 1028 3.8e-110 Arginyl-tRNA--protein transferase 1 OS=Mus musculus GN=Ate1 PE=1 SV=2 PF04377//PF04376 Arginine-tRNA-protein transferase, C terminus//Arginine-tRNA-protein transferase, N terminus GO:0016598 protein arginylation GO:0004057 arginyltransferase activity -- -- KOG1193 Arginyl-tRNA-protein transferase Cluster-8309.28514 BF_2 11.00 1.39 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28516 BF_2 602.48 9.22 3021 642932072 XP_008196845.1 1734 1.7e-190 PREDICTED: thioredoxin domain-containing protein 11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4FUW8 385 1.8e-35 Thioredoxin domain-containing protein 11 OS=Bos taurus GN=TXNDC11 PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- -- -- Cluster-8309.28517 BF_2 186.80 3.57 2473 642914301 XP_008201628.1 200 1.0e-12 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X1 [Tribolium castaneum] 462293333 APGK01053470.1 36 1.08631e-06 Dendroctonus ponderosae Seq01053480, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF06888//PF02723//PF03153//PF03938 Putative Phosphatase//Non-structural protein NS3/Small envelope protein E//Transcription factor IIA, alpha/beta subunit//Outer membrane protein (OmpH-like) GO:0006367//GO:0008152 transcription initiation from RNA polymerase II promoter//metabolic process GO:0016791//GO:0051082 phosphatase activity//unfolded protein binding GO:0005672//GO:0016020 transcription factor TFIIA complex//membrane -- -- Cluster-8309.28519 BF_2 127.00 19.54 559 642914303 XP_001815546.2 567 6.5e-56 PREDICTED: mediator of RNA polymerase II transcription subunit 28 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15141 MED28 mediator of RNA polymerase II transcription subunit 28 http://www.genome.jp/dbget-bin/www_bget?ko:K15141 Q17P98 351 3.0e-32 Mediator of RNA polymerase II transcription subunit 28 OS=Aedes aegypti GN=MED28 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2852 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28520 BF_2 53.29 3.29 964 546684237 ERL93942.1 434 3.0e-40 hypothetical protein D910_11228 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28521 BF_2 74.86 3.70 1134 642928615 XP_968715.2 625 2.5e-62 PREDICTED: uncharacterized protein LOC657146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.28523 BF_2 345.00 9.83 1755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28524 BF_2 810.83 12.42 3019 642933781 XP_008197271.1 3154 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 16 isoform X2 [Tribolium castaneum]>gi|270013594|gb|EFA10042.1| hypothetical protein TcasGA2_TC012214 [Tribolium castaneum] -- -- -- -- -- K09536 DNAJC16 DnaJ homolog subfamily C member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K09536 Q5RCM7 839 4.2e-88 DnaJ homolog subfamily C member 16 OS=Pongo abelii GN=DNAJC16 PE=2 SV=1 PF02180//PF08534//PF00085//PF00578 Bcl-2 homology region 4//Redoxin//Thioredoxin//AhpC/TSA family GO:0006457//GO:0055114//GO:0045454//GO:0042981 protein folding//oxidation-reduction process//cell redox homeostasis//regulation of apoptotic process GO:0031072//GO:0016491//GO:0051082//GO:0016209 heat shock protein binding//oxidoreductase activity//unfolded protein binding//antioxidant activity -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.28527 BF_2 41.00 0.44 4156 642913636 XP_008201097.1 3169 0.0e+00 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum]>gi|270002053|gb|EEZ98500.1| hypothetical protein TcasGA2_TC001001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W596 1752 7.8e-194 Microtubule-associated protein futsch OS=Drosophila melanogaster GN=futsch PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28531 BF_2 87.27 1.54 2662 91078216 XP_969175.1 1172 2.2e-125 PREDICTED: surfeit locus protein 4 homolog [Tribolium castaneum]>gi|270001352|gb|EEZ97799.1| hypothetical protein TcasGA2_TC000161 [Tribolium castaneum] 225718617 BT080731.1 73 3.1637e-27 Caligus clemensi clone ccle-evs-519-002 Surfeit locus protein 4 homolog putative mRNA, complete cds K03593 mrp, NUBPL ATP-binding protein involved in chromosome partitioning http://www.genome.jp/dbget-bin/www_bget?ko:K03593 O18405 988 1.9e-105 Surfeit locus protein 4 homolog OS=Drosophila melanogaster GN=Surf4 PE=2 SV=1 PF03419//PF02077 Sporulation factor SpoIIGA//SURF4 family GO:0006508//GO:0030436 proteolysis//asexual sporulation GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.28532 BF_2 90.00 3.35 1412 270007275 EFA03723.1 344 1.2e-29 hypothetical protein TcasGA2_TC013828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 363 3.0e-33 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.28534 BF_2 3.67 0.48 609 189237918 XP_001811805.1 225 3.2e-16 PREDICTED: transcription initiation factor TFIID subunit 6 [Tribolium castaneum]>gi|270006675|gb|EFA03123.1| hypothetical protein TcasGA2_TC013033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28538 BF_2 15.24 0.54 1458 478254871 ENN75107.1 500 9.9e-48 hypothetical protein YQE_08420, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D3D0 152 9.2e-09 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28539 BF_2 128.56 5.58 1251 332372700 AEE61492.1 947 1.3e-99 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7QBJ0 606 1.8e-61 UPF0483 protein AGAP003155 OS=Anopheles gambiae GN=AGAP003155 PE=3 SV=3 PF02230//PF06821 Phospholipase/Carboxylesterase//Serine hydrolase -- -- GO:0016787 hydrolase activity -- -- KOG2551 Phospholipase/carboxyhydrolase Cluster-8309.28541 BF_2 37.27 0.34 4898 642914971 XP_008190464.1 1011 1.9e-106 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 2.10528e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 392 4.6e-36 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF01585//PF00322//PF05680//PF06703 G-patch domain//Endothelin family//ATP synthase E chain//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465//GO:0019229//GO:0015992//GO:0015986 signal peptide processing//regulation of vasoconstriction//proton transport//ATP synthesis coupled proton transport GO:0008233//GO:0015078//GO:0003676 peptidase activity//hydrogen ion transmembrane transporter activity//nucleic acid binding GO:0016021//GO:0005787//GO:0000276//GO:0005576 integral component of membrane//signal peptidase complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//extracellular region -- -- Cluster-8309.28543 BF_2 52.00 1.14 2188 321458007 EFX69083.1 2650 7.4e-297 hypothetical protein DAPPUDRAFT_329474 [Daphnia pulex] 657566975 XM_008288631.1 186 3.95753e-90 PREDICTED: Stegastes partitus glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 (LOC103362312), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 2266 1.0e-253 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF13580//PF01380 SIS domain//SIS domain GO:0005975 carbohydrate metabolic process GO:0030246 carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.28544 BF_2 44.00 1.03 2074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28545 BF_2 1.00 0.33 413 240849643 NP_001155867.1 196 5.0e-13 translocase of outer mitochondrial membrane 7 homolog [Nasonia vitripennis]>gi|645004190|ref|XP_008208148.1| PREDICTED: translocase of outer mitochondrial membrane 7 homolog isoform X1 [Nasonia vitripennis]>gi|645004192|ref|XP_008208152.1| PREDICTED: translocase of outer mitochondrial membrane 7 homolog isoform X1 [Nasonia vitripennis]>gi|645004194|ref|XP_008208156.1| PREDICTED: translocase of outer mitochondrial membrane 7 homolog isoform X1 [Nasonia vitripennis] -- -- -- -- -- K17771 TOM7 mitochondrial import receptor subunit TOM7 http://www.genome.jp/dbget-bin/www_bget?ko:K17771 Q2KI08 158 5.2e-10 Mitochondrial import receptor subunit TOM7 homolog OS=Bos taurus GN=TOMM7 PE=3 SV=1 PF08038 TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005742 mitochondrial outer membrane translocase complex KOG4449 Translocase of outer mitochondrial membrane complex, subunit TOM7 Cluster-8309.28547 BF_2 462.17 1.95 10227 270008428 EFA04876.1 9007 0.0e+00 hypothetical protein TcasGA2_TC014935 [Tribolium castaneum] -- -- -- -- -- K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 P42356 4980 0.0e+00 Phosphatidylinositol 4-kinase alpha OS=Homo sapiens GN=PI4KA PE=1 SV=3 PF07721//PF13181//PF00899//PF00454//PF08240//PF00515//PF13374//PF00106//PF00107//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//ThiF family//Phosphatidylinositol 3- and 4-kinase//Alcohol dehydrogenase GroES-like domain//Tetratricopeptide repeat//Tetratricopeptide repeat//short chain dehydrogenase//Zinc-binding dehydrogenase//TPR repeat GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0005515//GO:0008641//GO:0042802//GO:0016773 oxidoreductase activity//protein binding//small protein activating enzyme activity//identical protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0902 Phosphatidylinositol 4-kinase Cluster-8309.28550 BF_2 190.91 3.18 2800 270003257 EEZ99704.1 685 6.8e-69 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q60HE9 463 1.5e-44 Lysosomal alpha-mannosidase OS=Macaca fascicularis GN=MAN2B1 PE=2 SV=1 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0015923 mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.28552 BF_2 19.84 0.79 1336 189240443 XP_972854.2 423 7.7e-39 PREDICTED: lysosomal-associated transmembrane protein 4B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00599 Influenza Matrix protein (M2) GO:0015992 proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.28553 BF_2 602.93 7.98 3449 91078712 XP_966534.1 1635 5.8e-179 PREDICTED: ethanolamine-phosphate cytidylyltransferase [Tribolium castaneum]>gi|270003752|gb|EFA00200.1| hypothetical protein TcasGA2_TC003025 [Tribolium castaneum] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 1228 3.7e-133 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF01467//PF06574//PF00154//PF02569 Cytidylyltransferase-like//FAD synthetase//recA bacterial DNA recombination protein//Pantoate-beta-alanine ligase GO:0019482//GO:0009058//GO:0006771//GO:0009432//GO:0009231//GO:0006281//GO:0015940 beta-alanine metabolic process//biosynthetic process//riboflavin metabolic process//SOS response//riboflavin biosynthetic process//DNA repair//pantothenate biosynthetic process GO:0016779//GO:0003919//GO:0004592//GO:0005524//GO:0003824//GO:0003697 nucleotidyltransferase activity//FMN adenylyltransferase activity//pantoate-beta-alanine ligase activity//ATP binding//catalytic activity//single-stranded DNA binding -- -- KOG2803 Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase Cluster-8309.28554 BF_2 574.15 5.12 4979 270005907 EFA02355.1 4597 0.0e+00 hypothetical protein TcasGA2_TC008027 [Tribolium castaneum] 665808556 XM_008554384.1 193 1.16669e-93 PREDICTED: Microplitis demolitor 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase-like (LOC103574835), mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 P13217 3579 0.0e+00 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster GN=norpA PE=1 SV=4 PF00387//PF00168 Phosphatidylinositol-specific phospholipase C, Y domain//C2 domain GO:0006629//GO:0035556//GO:0009395//GO:0046339//GO:0007165 lipid metabolic process//intracellular signal transduction//phospholipid catabolic process//diacylglycerol metabolic process//signal transduction GO:0005515//GO:0004435 protein binding//phosphatidylinositol phospholipase C activity -- -- KOG1265 Phospholipase C Cluster-8309.28555 BF_2 41.06 0.56 3363 189236409 XP_001812701.1 2221 6.3e-247 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform X1 [Tribolium castaneum] 665808556 XM_008554384.1 189 1.31403e-91 PREDICTED: Microplitis demolitor 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase-like (LOC103574835), mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 P13217 1745 4.1e-193 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster GN=norpA PE=1 SV=4 PF00168//PF00387 C2 domain//Phosphatidylinositol-specific phospholipase C, Y domain GO:0006629//GO:0035556//GO:0009395//GO:0007165//GO:0046339 lipid metabolic process//intracellular signal transduction//phospholipid catabolic process//signal transduction//diacylglycerol metabolic process GO:0005515//GO:0004435 protein binding//phosphatidylinositol phospholipase C activity -- -- KOG1265 Phospholipase C Cluster-8309.28556 BF_2 730.79 6.87 4738 189236409 XP_001812701.1 4597 0.0e+00 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase isoform X1 [Tribolium castaneum] 665808556 XM_008554384.1 193 1.10981e-93 PREDICTED: Microplitis demolitor 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase-like (LOC103574835), mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 P13217 3579 0.0e+00 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase OS=Drosophila melanogaster GN=norpA PE=1 SV=4 PF00387//PF00168 Phosphatidylinositol-specific phospholipase C, Y domain//C2 domain GO:0007165//GO:0046339//GO:0009395//GO:0035556//GO:0006629 signal transduction//diacylglycerol metabolic process//phospholipid catabolic process//intracellular signal transduction//lipid metabolic process GO:0004435//GO:0005515 phosphatidylinositol phospholipase C activity//protein binding -- -- KOG1265 Phospholipase C Cluster-8309.28562 BF_2 547.38 10.30 2510 546681672 ERL91720.1 1516 2.6e-165 hypothetical protein D910_09047 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF01465//PF05478//PF02041 Leucine rich repeat//GRIP domain//Prominin//Auxin binding protein GO:0007165//GO:0000042 signal transduction//protein targeting to Golgi GO:0004872//GO:0005515 receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.28564 BF_2 619.99 83.43 598 91078074 XP_971898.1 262 1.6e-20 PREDICTED: V-type proton ATPase subunit e 2 [Tribolium castaneum] -- -- -- -- -- K02153 ATPeV0E, ATP6H V-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02153 Q20591 156 1.3e-09 V-type proton ATPase subunit e OS=Caenorhabditis elegans GN=vha-17 PE=3 SV=2 PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG3500 Vacuolar H+-ATPase V0 sector, subunit M9.7 (M9.2) Cluster-8309.28565 BF_2 55.60 2.45 1238 642931814 XP_008196744.1 782 1.7e-80 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 565 1.0e-56 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF06584 Cytochrome P450//DIRP GO:0007049//GO:0055114//GO:0006351 cell cycle//oxidation-reduction process//transcription, DNA-templated GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0017053 transcriptional repressor complex -- -- Cluster-8309.28568 BF_2 1.00 33.02 206 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28571 BF_2 34.82 0.36 4303 642923337 XP_008193707.1 2548 9.7e-285 PREDICTED: uncharacterized protein LOC103313102 [Tribolium castaneum]>gi|270007619|gb|EFA04067.1| hypothetical protein TcasGA2_TC014301 [Tribolium castaneum] 170035242 XM_001845428.1 49 1.12784e-13 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P22792 295 7.1e-25 Carboxypeptidase N subunit 2 OS=Homo sapiens GN=CPN2 PE=1 SV=3 PF00560//PF14999//PF13855 Leucine Rich Repeat//Shadow of prion protein, neuroprotective//Leucine rich repeat -- -- GO:0005515 protein binding GO:0031225 anchored component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.28572 BF_2 53.00 20.48 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28573 BF_2 158.00 3.33 2272 221061293 XP_002262216.1 142 5.0e-06 hypothetical protein, conserved in Plasmodium species [Plasmodium knowlesi strain H]>gi|193811366|emb|CAQ42094.1| hypothetical protein, conserved in Plasmodium species [Plasmodium knowlesi strain H] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28575 BF_2 447.40 5.37 3773 642935735 XP_008198150.1 3183 0.0e+00 PREDICTED: RNA polymerase II-associated protein 1 [Tribolium castaneum]>gi|270013972|gb|EFA10420.1| hypothetical protein TcasGA2_TC012660 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JN53 513 3.3e-50 RNA polymerase II-associated protein 1 OS=Bos taurus GN=RPAP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4732 Uncharacterized conserved protein Cluster-8309.28576 BF_2 57.87 2.74 1170 805773862 XP_012137327.1 692 4.4e-70 PREDICTED: papilin isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q868Z9 605 2.2e-61 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.28577 BF_2 179.00 6.10 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28578 BF_2 971.00 22.39 2101 478251367 ENN71833.1 848 6.4e-88 hypothetical protein YQE_11453, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P4W3 355 3.8e-32 Regulator of microtubule dynamics protein 2 OS=Xenopus tropicalis GN=rmdn2 PE=2 SV=1 PF13414//PF16740 TPR repeat//Spindle and kinetochore-associated protein 2 GO:0031110//GO:0051301//GO:0007067//GO:0000090//GO:0007059 regulation of microtubule polymerization or depolymerization//cell division//mitotic nuclear division//mitotic anaphase//chromosome segregation GO:0008017//GO:0005515 microtubule binding//protein binding GO:0000940//GO:0005876//GO:0045298 condensed chromosome outer kinetochore//spindle microtubule//tubulin complex -- -- Cluster-8309.28579 BF_2 926.15 10.51 3975 91093345 XP_967700.1 926 1.1e-96 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X9 [Tribolium castaneum] 642938317 XM_962607.3 325 3.89006e-167 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 P81269 205 1.8e-14 Cyclic AMP-dependent transcription factor ATF-1 OS=Mus musculus GN=Atf1 PE=1 SV=1 PF00170//PF07716//PF02173//PF03131 bZIP transcription factor//Basic region leucine zipper//pKID domain//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0005515//GO:0003700 DNA binding//sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.28586 BF_2 8.59 0.34 1355 546677930 ERL88668.1 547 3.3e-53 hypothetical protein D910_06052, partial [Dendroctonus ponderosae] -- -- -- -- -- K08495 GOSR1, GOS1 golgi SNAP receptor complex member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08495 Q9VE50 294 2.9e-25 Golgi SNAP receptor complex member 1 OS=Drosophila melanogaster GN=Gos28 PE=2 SV=1 PF08912//PF10384//PF04632 Rho Binding//Centromere protein Scm3//Fusaric acid resistance protein family GO:0006810 transport GO:0017048//GO:0042393 Rho GTPase binding//histone binding GO:0005886//GO:0005634 plasma membrane//nucleus KOG3208 SNARE protein GS28 Cluster-8309.28587 BF_2 201.41 8.30 1302 91084689 XP_968899.1 885 2.0e-92 PREDICTED: Golgi SNAP receptor complex member 1 [Tribolium castaneum]>gi|270008620|gb|EFA05068.1| hypothetical protein TcasGA2_TC015165 [Tribolium castaneum] -- -- -- -- -- K08495 GOSR1, GOS1 golgi SNAP receptor complex member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08495 Q9VE50 576 5.6e-58 Golgi SNAP receptor complex member 1 OS=Drosophila melanogaster GN=Gos28 PE=2 SV=1 PF08912//PF04632 Rho Binding//Fusaric acid resistance protein family GO:0006888//GO:0006810//GO:0015031 ER to Golgi vesicle-mediated transport//transport//protein transport GO:0017048 Rho GTPase binding GO:0005886//GO:0016021//GO:0005801//GO:0000139 plasma membrane//integral component of membrane//cis-Golgi network//Golgi membrane KOG3208 SNARE protein GS28 Cluster-8309.28590 BF_2 992.40 36.04 1439 546681363 ERL91473.1 1521 4.0e-166 hypothetical protein D910_08803 [Dendroctonus ponderosae] 817195914 XM_012418095.1 260 1.88527e-131 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1373 2.4e-150 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.28591 BF_2 238.35 1.51 6887 270012867 EFA09315.1 1048 1.3e-110 hypothetical protein TcasGA2_TC030748 [Tribolium castaneum] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 532 3.8e-52 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 PF04420//PF08288//PF07830 CHD5-like protein//PIGA (GPI anchor biosynthesis)//Protein serine/threonine phosphatase 2C, C-terminal domain GO:0006506//GO:0071816//GO:0006470 GPI anchor biosynthetic process//tail-anchored membrane protein insertion into ER membrane//protein dephosphorylation GO:0000287//GO:0004721//GO:0030145 magnesium ion binding//phosphoprotein phosphatase activity//manganese ion binding -- -- KOG2687 Spindle pole body protein, contains UNC-84 domain Cluster-8309.28593 BF_2 21.77 0.34 2932 642928862 XP_008195593.1 1089 1.0e-115 PREDICTED: probable ATP-dependent RNA helicase DDX43 [Tribolium castaneum] -- -- -- -- -- K17043 DDX43 ATP-dependent RNA helicase DDX43 http://www.genome.jp/dbget-bin/www_bget?ko:K17043 Q9NXZ2 762 3.4e-79 Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens GN=DDX43 PE=2 SV=2 PF07650//PF00270//PF04851//PF13014//PF00176//PF02730//PF00013 KH domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//KH domain//SNF2 family N-terminal domain//Aldehyde ferredoxin oxidoreductase, N-terminal domain//KH domain GO:0055114 oxidation-reduction process GO:0016491//GO:0003723//GO:0005524//GO:0003677//GO:0016787//GO:0016625//GO:0051536//GO:0003676 oxidoreductase activity//RNA binding//ATP binding//DNA binding//hydrolase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//iron-sulfur cluster binding//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.28595 BF_2 25.25 0.55 2222 642914654 XP_008190301.1 668 5.0e-67 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28596 BF_2 537.99 5.02 4769 642914654 XP_008190301.1 1656 2.9e-181 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.73957e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF00170//PF07716 bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.28597 BF_2 5.00 0.59 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2860 BF_2 7.00 0.76 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28600 BF_2 695.33 7.95 3948 642919036 XP_008191706.1 1793 3.2e-197 PREDICTED: uncharacterized protein LOC663686 isoform X2 [Tribolium castaneum] 749755207 XM_011141773.1 86 2.79471e-34 PREDICTED: Harpegnathos saltator uncharacterized LOC105183546 (LOC105183546), mRNA -- -- -- -- -- -- -- -- PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.28602 BF_2 118.41 2.59 2199 665820747 XP_008559286.1 1602 2.5e-175 PREDICTED: guanine nucleotide-binding protein subunit beta-5 [Microplitis demolitor] 807025222 XM_004523529.2 192 1.83762e-93 PREDICTED: Ceratitis capitata guanine nucleotide-binding protein subunit beta-5 (LOC101456443), mRNA K04539 GNB5 guanine nucleotide-binding protein subunit beta-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04539 Q6PNB6 1309 9.6e-143 Guanine nucleotide-binding protein subunit beta-5 OS=Oryctolagus cuniculus GN=GNB5 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.28606 BF_2 34.84 1.26 1444 642936242 XP_008198362.1 1627 2.0e-178 PREDICTED: polypyrimidine tract-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 781 1.1e-81 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.28609 BF_2 1177.91 8.87 5844 642939380 XP_008193163.1 2484 3.5e-277 PREDICTED: hemicentin-1 isoform X3 [Tribolium castaneum] 642939379 XM_008194941.1 107 8.79284e-46 PREDICTED: Tribolium castaneum hemicentin-1 (LOC660515), transcript variant X3, mRNA -- -- -- -- Q8WZ42 332 5.0e-29 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF00558//PF00895//PF05510//PF13895//PF06377//PF00957 Vpu protein//ATP synthase protein 8//Sarcoglycan alpha/epsilon//Immunoglobulin domain//Adipokinetic hormone//Synaptobrevin GO:0015992//GO:0032801//GO:0006812//GO:0015986//GO:0016192//GO:0019076//GO:0007165 proton transport//receptor catabolic process//cation transport//ATP synthesis coupled proton transport//vesicle-mediated transport//viral release from host cell//signal transduction GO:0015078//GO:0005179//GO:0005261//GO:0005515 hydrogen ion transmembrane transporter activity//hormone activity//cation channel activity//protein binding GO:0033644//GO:0016012//GO:0000276//GO:0016021 host cell membrane//sarcoglycan complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.28610 BF_2 1505.15 18.08 3770 189242341 XP_001807206.1 2621 2.9e-293 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270016565|gb|EFA13011.1| hypothetical protein TcasGA2_TC001976 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 314 3.9e-27 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28612 BF_2 38.11 0.31 5366 642939012 XP_008197805.1 3065 0.0e+00 PREDICTED: exportin-4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0E2 1558 3.1e-171 Exportin-4 OS=Homo sapiens GN=XPO4 PE=1 SV=2 PF03810 Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0008536 Ran GTPase binding -- -- KOG4541 Nuclear transport receptor exportin 4 (importin beta superfamily) Cluster-8309.28613 BF_2 92.94 2.52 1830 478263026 ENN81426.1 1545 8.4e-169 hypothetical protein YQE_02120, partial [Dendroctonus ponderosae]>gi|546686068|gb|ERL95468.1| hypothetical protein D910_12730 [Dendroctonus ponderosae] 56251666 CR676700.2 57 1.69492e-18 Tetraodon nigroviridis full-length cDNA K10755 RFC2_4 replication factor C subunit 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10755 P53033 1260 3.8e-137 Replication factor C subunit 2 OS=Gallus gallus GN=RFC2 PE=2 SV=1 PF07728//PF05496//PF01443//PF00004//PF06144//PF07726//PF03266//PF00005//PF00270//PF00910 AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//ATPase family associated with various cellular activities (AAA)//DNA polymerase III, delta subunit//ATPase family associated with various cellular activities (AAA)//NTPase//ABC transporter//DEAD/DEAH box helicase//RNA helicase GO:0006310//GO:0006281//GO:0006260 DNA recombination//DNA repair//DNA replication GO:0003723//GO:0003677//GO:0003887//GO:0003676//GO:0009378//GO:0003724//GO:0005524//GO:0098519//GO:0016887 RNA binding//DNA binding//DNA-directed DNA polymerase activity//nucleic acid binding//four-way junction helicase activity//RNA helicase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//ATPase activity GO:0005657//GO:0009360//GO:0009379//GO:0042575 replication fork//DNA polymerase III complex//Holliday junction helicase complex//DNA polymerase complex KOG0991 Replication factor C, subunit RFC2 Cluster-8309.28615 BF_2 418.64 5.56 3439 91078790 XP_969765.1 2074 7.2e-230 PREDICTED: retinoblastoma-binding protein 5 [Tribolium castaneum]>gi|270003731|gb|EFA00179.1| hypothetical protein TcasGA2_TC003004 [Tribolium castaneum] 815929092 XM_003494688.2 345 2.56149e-178 PREDICTED: Bombus impatiens retinoblastoma-binding protein 5 homolog (LOC100746759), mRNA K14961 RBBP5, SWD1, CPS50 COMPASS component SWD1 http://www.genome.jp/dbget-bin/www_bget?ko:K14961 Q9VPH8 1792 1.5e-198 Retinoblastoma-binding protein 5 homolog OS=Drosophila melanogaster GN=Rbbp5 PE=1 SV=2 PF01459//PF01239//PF00400 Eukaryotic porin//Protein prenyltransferase alpha subunit repeat//WD domain, G-beta repeat GO:0018342//GO:0055085 protein prenylation//transmembrane transport GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity GO:0005741 mitochondrial outer membrane KOG1273 WD40 repeat protein Cluster-8309.28619 BF_2 83.10 2.31 1795 546681897 ERL91906.1 877 2.4e-91 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 468 2.6e-45 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.28620 BF_2 8.00 3.39 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28622 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28624 BF_2 1.00 0.35 405 478252918 ENN73302.1 158 1.2e-08 hypothetical protein YQE_10066, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03504 Chlamydia cysteine-rich outer membrane protein 6 -- -- GO:0005201 extracellular matrix structural constituent GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.28627 BF_2 39.09 1.69 1256 827552646 XP_012548082.1 534 9.8e-52 PREDICTED: LOW QUALITY PROTEIN: p270 isoform X1 [Bombyx mori] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 432 2.7e-41 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00106//PF00107 short chain dehydrogenase//Zinc-binding dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.28629 BF_2 74.81 3.40 1207 546683825 ERL93578.1 502 4.8e-48 hypothetical protein D910_10866 [Dendroctonus ponderosae] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q06190 158 1.5e-09 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens GN=PPP2R3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28630 BF_2 13.00 0.55 1274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28631 BF_2 251.16 3.89 2988 573875180 XP_006625928.1 321 1.2e-26 PREDICTED: serine/threonine-protein kinase Nek2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O35942 287 4.2e-24 Serine/threonine-protein kinase Nek2 OS=Mus musculus GN=Nek2 PE=1 SV=2 PF08040//PF00800//PF07714//PF00069 MNLL subunit//Prephenate dehydratase//Protein tyrosine kinase//Protein kinase domain GO:0006118//GO:0009094//GO:0000162//GO:0006571//GO:0006468 obsolete electron transport//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//tyrosine biosynthetic process//protein phosphorylation GO:0004672//GO:0005524//GO:0004664//GO:0003954 protein kinase activity//ATP binding//prephenate dehydratase activity//NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-8309.28634 BF_2 208.44 1.89 4892 642921170 XP_008192744.1 2383 1.5e-265 PREDICTED: ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K05657 ABCB10 ATP-binding cassette, subfamily B (MDR/TAP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05657 Q9NRK6 1543 1.6e-169 ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens GN=ABCB10 PE=1 SV=2 PF14991//PF00005//PF03193//PF07728//PF00664//PF06414//PF13304 Protein melan-A//ABC transporter//Protein of unknown function, DUF258//AAA domain (dynein-related subfamily)//ABC transporter transmembrane region//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626 ATP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0042470 integral component of membrane//melanosome KOG0058 Peptide exporter, ABC superfamily Cluster-8309.28636 BF_2 1122.59 29.10 1901 270013779 EFA10227.1 582 4.0e-57 hypothetical protein TcasGA2_TC012423 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20241 232 6.4e-18 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- KOG3513 Neural cell adhesion molecule L1 Cluster-8309.28637 BF_2 16.98 4.25 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01095 Pectinesterase GO:0005985//GO:0005982//GO:0042545 sucrose metabolic process//starch metabolic process//cell wall modification GO:0030599 pectinesterase activity GO:0005618 cell wall -- -- Cluster-8309.28640 BF_2 5.87 3.50 353 270011968 EFA08416.1 262 9.5e-21 hypothetical protein TcasGA2_TC006063 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28643 BF_2 776.31 8.55 4087 189241411 XP_970340.2 5384 0.0e+00 PREDICTED: attractin-like protein 1 [Tribolium castaneum]>gi|270014130|gb|EFA10578.1| hypothetical protein TcasGA2_TC012834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6A051 1305 5.2e-142 Attractin-like protein 1 OS=Mus musculus GN=Atrnl1 PE=1 SV=2 PF01344//PF01437//PF07646 Kelch motif//Plexin repeat//Kelch motif -- -- GO:0005515 protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1388 Attractin and platelet-activating factor acetylhydrolase Cluster-8309.28644 BF_2 46.69 0.36 5654 189241411 XP_970340.2 4840 0.0e+00 PREDICTED: attractin-like protein 1 [Tribolium castaneum]>gi|270014130|gb|EFA10578.1| hypothetical protein TcasGA2_TC012834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6A051 1305 7.2e-142 Attractin-like protein 1 OS=Mus musculus GN=Atrnl1 PE=1 SV=2 PF07646//PF01344//PF01437 Kelch motif//Kelch motif//Plexin repeat -- -- GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1388 Attractin and platelet-activating factor acetylhydrolase Cluster-8309.28645 BF_2 83.52 0.44 8151 642920053 XP_008192184.1 1927 1.9e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 2.75388e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 2.7e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF08159//PF03822//PF08445//PF13508//PF00583//PF02297//PF03396//PF13673//PF00159 NUC153 domain//NAF domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Cytochrome oxidase c subunit VIb//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide GO:0019083//GO:0007165//GO:0006123//GO:0042967//GO:0015992//GO:0006351//GO:0006144//GO:0006206 viral transcription//signal transduction//mitochondrial electron transport, cytochrome c to oxygen//acyl-carrier-protein biosynthetic process//proton transport//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005179//GO:0008080//GO:0016747//GO:0004129 DNA-directed RNA polymerase activity//DNA binding//hormone activity//N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity GO:0005739//GO:0005730//GO:0005634//GO:0045277//GO:0005576 mitochondrion//nucleolus//nucleus//respiratory chain complex IV//extracellular region KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.28647 BF_2 124.62 1.23 4519 478261514 ENN80859.1 815 9.2e-84 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K08648 HABP2 hyaluronan binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08648 P13582 508 1.5e-49 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.28649 BF_2 53.00 2.00 1393 642927692 XP_008196560.1 758 1.2e-77 PREDICTED: DNA-directed RNA polymerase I subunit RPA49-like [Tribolium castaneum]>gi|270009901|gb|EFA06349.1| hypothetical protein TcasGA2_TC009224 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06870 A49-like RNA polymerase I associated factor GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.28653 BF_2 723.51 3.60 8705 189233577 XP_968497.2 1756 1.4e-192 PREDICTED: protein capicua homolog isoform X1 [Tribolium castaneum]>gi|270015125|gb|EFA11573.1| capicua [Tribolium castaneum] 642910253 XM_008200351.1 160 4.52217e-75 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X2, mRNA -- -- -- -- Q96RK0 381 1.5e-34 Protein capicua homolog OS=Homo sapiens GN=CIC PE=1 SV=2 PF08288 PIGA (GPI anchor biosynthesis) GO:0006506 GPI anchor biosynthetic process -- -- -- -- KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.28654 BF_2 1227.97 28.67 2079 478250009 ENN70515.1 538 5.6e-52 hypothetical protein YQE_12691, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 332 1.8e-29 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.28658 BF_2 51.16 0.80 2958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28659 BF_2 932.55 21.73 2082 270014846 EFA11294.1 1705 2.7e-187 hypothetical protein TcasGA2_TC010831 [Tribolium castaneum] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 P41239 1033 9.2e-111 Tyrosine-protein kinase CSK OS=Gallus gallus GN=CSK PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.28661 BF_2 87.87 1.31 3088 91075916 XP_966441.1 3317 0.0e+00 PREDICTED: exocyst complex component 2 [Tribolium castaneum]>gi|270014638|gb|EFA11086.1| hypothetical protein TcasGA2_TC004683 [Tribolium castaneum] -- -- -- -- -- K17637 EXOC2, SEC5 exocyst complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17637 Q9VQQ9 1888 9.8e-210 Exocyst complex component 2 OS=Drosophila melanogaster GN=sec5 PE=2 SV=1 PF04437//PF01833 RINT-1 / TIP-1 family//IPT/TIG domain GO:0048193 Golgi vesicle transport GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG2347 Sec5 subunit of exocyst complex Cluster-8309.28662 BF_2 112.06 1.42 3587 642936999 XP_968421.2 962 6.6e-101 PREDICTED: 60 kDa SS-A/Ro ribonucleoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42700 346 7.3e-31 60 kDa SS-A/Ro ribonucleoprotein OS=Xenopus laevis GN=trove2 PE=1 SV=1 PF02285//PF05731 Cytochrome oxidase c subunit VIII//TROVE domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003723 cytochrome-c oxidase activity//RNA binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.28666 BF_2 164.54 1.60 4588 270005308 EFA01756.1 572 1.4e-55 hypothetical protein TcasGA2_TC007354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- -- -- Cluster-8309.28670 BF_2 303.23 4.55 3078 91088947 XP_973771.1 2772 7.2e-311 PREDICTED: exocyst complex component 3 [Tribolium castaneum]>gi|270012371|gb|EFA08819.1| hypothetical protein TcasGA2_TC006514 [Tribolium castaneum] -- -- -- -- -- K06110 EXOC3, SEC6L1 exocyst complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06110 Q9V8K2 1730 2.0e-191 Exocyst complex component 3 OS=Drosophila melanogaster GN=sec6 PE=2 SV=2 PF05192//PF03283//PF06046 MutS domain III//Pectinacetylesterase//Exocyst complex component Sec6 GO:0006887//GO:0006298 exocytosis//mismatch repair GO:0016787//GO:0030983//GO:0005524 hydrolase activity//mismatched DNA binding//ATP binding GO:0000145 exocyst KOG2286 Exocyst complex subunit SEC6 Cluster-8309.28672 BF_2 21.72 1.14 1083 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28675 BF_2 518.84 5.42 4294 189241218 XP_971240.2 3957 0.0e+00 PREDICTED: trafficking protein particle complex subunit 11 isoform X1 [Tribolium castaneum] 805824905 XM_003708183.2 71 6.63129e-26 PREDICTED: Megachile rotundata trafficking protein particle complex subunit 11 (LOC100881733), mRNA -- -- -- -- Q7Z392 2179 2.5e-243 Trafficking protein particle complex subunit 11 OS=Homo sapiens GN=TRAPPC11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4386 Uncharacterized conserved protein Cluster-8309.28676 BF_2 164.64 8.76 1073 91090510 XP_969573.1 1015 1.4e-107 PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum]>gi|642935364|ref|XP_008197982.1| PREDICTED: palmitoyltransferase ZDHHC23 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q8IYP9 147 2.6e-08 Palmitoyltransferase ZDHHC23 OS=Homo sapiens GN=ZDHHC23 PE=1 SV=3 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.28678 BF_2 46.02 0.76 2805 91078996 XP_974675.1 283 2.8e-22 PREDICTED: zinc transporter ZIP1 [Tribolium castaneum]>gi|270003679|gb|EFA00127.1| hypothetical protein TcasGA2_TC002943 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 -- -- -- -- PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.28680 BF_2 1137.22 13.86 3719 546684921 ERL94503.1 2397 2.7e-267 hypothetical protein D910_11780 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96MT7 747 2.4e-77 Cilia- and flagella-associated protein 44 OS=Homo sapiens GN=CFAP44 PE=1 SV=1 PF00400//PF00591 WD domain, G-beta repeat//Glycosyl transferase family, a/b domain GO:0008152 metabolic process GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.28681 BF_2 188.23 2.67 3233 642924596 XP_008194357.1 2788 0.0e+00 PREDICTED: putative ATP-dependent RNA helicase DHX33 [Tribolium castaneum]>gi|270006741|gb|EFA03189.1| hypothetical protein TcasGA2_TC013109 [Tribolium castaneum] -- -- -- -- -- K17820 DHX33 ATP-dependent RNA helicase DHX33 http://www.genome.jp/dbget-bin/www_bget?ko:K17820 Q80VY9 1714 1.5e-189 Putative ATP-dependent RNA helicase DHX33 OS=Mus musculus GN=Dhx33 PE=1 SV=1 PF04408//PF01637//PF04851//PF00005//PF07652//PF00270//PF00437 Helicase associated domain (HA2)//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter//Flavivirus DEAD domain//DEAD/DEAH box helicase//Type II/IV secretion system protein GO:0006810//GO:0019079 transport//viral genome replication GO:0008026//GO:0005524//GO:0004386//GO:0016787//GO:0003677//GO:0003676//GO:0016887 ATP-dependent helicase activity//ATP binding//helicase activity//hydrolase activity//DNA binding//nucleic acid binding//ATPase activity -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.28682 BF_2 194.93 4.24 2209 332373870 AEE62076.1 1566 3.7e-171 unknown [Dendroctonus ponderosae] 198456406 XM_001360273.2 35 3.484e-06 Drosophila pseudoobscura pseudoobscura GA13487 (Dpse\GA13487), partial mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 909 2.3e-96 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28684 BF_2 438.15 8.39 2472 91088333 XP_970609.1 1016 2.5e-107 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011789|gb|EFA08237.1| hypothetical protein TcasGA2_TC005865 [Tribolium castaneum] -- -- -- -- -- K12302 SLC17A6_7_8 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12302 Q9V7S5 552 6.5e-55 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28685 BF_2 205.74 3.53 2722 91083281 XP_974400.1 2330 1.2e-259 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|270007725|gb|EFA04173.1| hypothetical protein TcasGA2_TC014422 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.28686 BF_2 34.51 0.57 2817 270004278 EFA00726.1 299 3.9e-24 hypothetical protein TcasGA2_TC003607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28687 BF_2 121.51 1.38 3973 642916650 XP_008192038.1 229 7.2e-16 PREDICTED: uncharacterized protein LOC103312652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28689 BF_2 29.77 0.76 1925 478257887 ENN78028.1 1256 2.9e-135 hypothetical protein YQE_05513, partial [Dendroctonus ponderosae] 768417656 XM_011551174.1 320 1.12371e-164 PREDICTED: Plutella xylostella exportin-1 (LOC105381447), mRNA K14290 XPO1, CRM1 exportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14290 Q80U96 1011 3.0e-108 Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.28691 BF_2 840.10 24.32 1732 642917767 XP_008191359.1 1648 9.0e-181 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 588 3.0e-59 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF01266//PF07992//PF05834//PF00732 GMC oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0055114//GO:0016117//GO:0044710 oxidation-reduction process//carotenoid biosynthetic process//single-organism metabolic process GO:0016491//GO:0016705//GO:0016614//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.28692 BF_2 303.94 4.07 3408 270297180 NP_001161912.1 858 7.2e-89 cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|268309002|gb|ACY95467.1| cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|270001714|gb|EEZ98161.1| hypothetical protein TcasGA2_TC000587 [Tribolium castaneum] 817213894 XM_012427772.1 132 6.46497e-60 PREDICTED: Orussus abietinus uncharacterized LOC105701218 (LOC105701218), mRNA -- -- -- -- -- -- -- -- PF01607//PF02975 Chitin binding Peritrophin-A domain//Methylamine dehydrogenase, L chain GO:0006030//GO:0009308//GO:0055114 chitin metabolic process//amine metabolic process//oxidation-reduction process GO:0008061//GO:0016638 chitin binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0005576//GO:0042597 extracellular region//periplasmic space -- -- Cluster-8309.28693 BF_2 854.52 11.34 3439 189237964 XP_001813896.1 3338 0.0e+00 PREDICTED: Golgi apparatus protein 1 [Tribolium castaneum]>gi|270006658|gb|EFA03106.1| hypothetical protein TcasGA2_TC013016 [Tribolium castaneum] -- -- -- -- -- K06816 GLG1, ESL1 golgi apparatus protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06816 Q02391 2052 1.0e-228 Golgi apparatus protein 1 OS=Gallus gallus GN=GLG1 PE=1 SV=1 PF00839 Cysteine rich repeat -- -- -- -- GO:0016020 membrane KOG3648 Golgi apparatus protein (cysteine-rich fibroblast growth factor receptor) Cluster-8309.28696 BF_2 32.00 2.57 809 641647727 XP_008179395.1 242 4.6e-18 PREDICTED: jerky protein homolog-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF05720 helix-turn-helix, Psq domain//Cell-cell adhesion domain GO:0007155 cell adhesion GO:0003677 DNA binding -- -- -- -- Cluster-8309.28697 BF_2 914.74 27.79 1664 270009554 EFA06002.1 986 5.0e-104 hypothetical protein TcasGA2_TC008828 [Tribolium castaneum] -- -- -- -- -- K08742 SIAH2 E3 ubiquitin-protein ligase SIAH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08742 A8X679 278 2.6e-23 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis briggsae GN=siah-1 PE=3 SV=2 PF15965//PF00097//PF03145//PF02891 TRAF-like zinc-finger//Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//MIZ/SP-RING zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.28698 BF_2 248.49 2.47 4500 642930899 XP_008196132.1 1295 2.0e-139 PREDICTED: protein suppressor of sable isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22293 356 6.3e-32 Protein suppressor of sable OS=Drosophila melanogaster GN=su(s) PE=1 SV=2 PF00642//PF06440 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DNA polymerase III, theta subunit GO:0006260 DNA replication GO:0003887//GO:0046872//GO:0003677 DNA-directed DNA polymerase activity//metal ion binding//DNA binding GO:0042575 DNA polymerase complex KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.28699 BF_2 84.30 1.00 3822 649572255 NP_001280540.1 1336 3.0e-144 FMRFamide receptor [Tribolium castaneum]>gi|91078222|ref|XP_969392.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915085|ref|XP_008190406.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915087|ref|XP_008190407.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|270002872|gb|EEZ99319.1| hypothetical protein TcasGA2_TC001381 [Tribolium castaneum]>gi|485836781|tpg|DAA64478.1| TPA_inf: FMRFamide-like G protein-coupled receptor [Tribolium castaneum] 158301538 XM_321207.2 76 9.79689e-29 Anopheles gambiae str. PEST AGAP001862-PA (GPRNNA1) mRNA, complete cds -- -- -- -- Q9VZW5 891 4.9e-94 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.28700 BF_2 15.28 0.38 1981 642915929 XP_008190815.1 150 5.2e-07 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05531//PF16331 Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation GO:0070206 protein trimerization -- -- GO:0019028 viral capsid -- -- Cluster-8309.28701 BF_2 118.00 9.53 805 270009937 EFA06385.1 346 4.0e-30 hypothetical protein TcasGA2_TC009263 [Tribolium castaneum] -- -- -- -- -- K08493 VTI1 vesicle transport through interaction with t-SNAREs 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08493 Q9UEU0 192 1.2e-13 Vesicle transport through interaction with t-SNAREs homolog 1B OS=Homo sapiens GN=VTI1B PE=1 SV=3 PF00523 Fusion glycoprotein F0 GO:0006948 induction by virus of host cell-cell fusion -- -- -- -- KOG1666 V-SNARE Cluster-8309.28706 BF_2 58.04 0.39 6542 642924126 XP_008194016.1 8939 0.0e+00 PREDICTED: neural-cadherin isoform X1 [Tribolium castaneum] 642924129 XM_008195796.1 2108 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X3, mRNA -- -- -- -- O15943 8312 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF01049//PF00028//PF00008 Cadherin cytoplasmic region//Cadherin domain//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.28707 BF_2 700.63 4.69 6542 642924132 XP_008194019.1 8991 0.0e+00 PREDICTED: neural-cadherin isoform X4 [Tribolium castaneum] 642924131 XM_008195797.1 2150 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X4, mRNA -- -- -- -- O15943 8442 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF00008//PF01049//PF00028 EGF-like domain//Cadherin cytoplasmic region//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.28712 BF_2 521.10 7.48 3201 91078858 XP_972061.1 1822 1.1e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 8.24809e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.3e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF02080//PF05577//PF09138 TrkA-C domain//Serine carboxypeptidase S28//Urm1 (Ubiquitin related modifier) GO:0034227//GO:0006508//GO:0006812//GO:0006813 tRNA thio-modification//proteolysis//cation transport//potassium ion transport GO:0008324//GO:0008236 cation transmembrane transporter activity//serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.28713 BF_2 37.26 9.16 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28715 BF_2 532.64 10.60 2390 642939327 XP_008200406.1 1139 1.3e-121 PREDICTED: DCN1-like protein 4 [Tribolium castaneum] 642939326 XM_008202184.1 281 6.70136e-143 PREDICTED: Tribolium castaneum DCN1-like protein 4 (LOC657768), mRNA K17824 DCUN1D4_5 DCN1-like protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K17824 Q5RHX6 783 1.0e-81 DCN1-like protein 4 OS=Danio rerio GN=dcun1d4 PE=3 SV=2 PF06268 Fascin domain -- -- GO:0051015//GO:0030674 actin filament binding//protein binding, bridging -- -- KOG3962 Predicted actin-bundling protein Cluster-8309.28716 BF_2 92.00 8.35 748 478254809 ENN75045.1 438 7.9e-41 hypothetical protein YQE_08360, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1LZ79 159 7.3e-10 Gem-associated protein 8 OS=Bos taurus GN=GEMIN8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28717 BF_2 631.39 4.20 6578 589060792 AHK26789.1 2872 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 2.58262e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2262 8.9e-253 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF02786//PF07478//PF02655//PF05896//PF00682 Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//ATP-grasp domain//Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//HMGL-like GO:0009252//GO:0055114//GO:0006814//GO:0006118//GO:0046436 peptidoglycan biosynthetic process//oxidation-reduction process//sodium ion transport//obsolete electron transport//D-alanine metabolic process GO:0046872//GO:0008716//GO:0016655//GO:0003824//GO:0005524 metal ion binding//D-alanine-D-alanine ligase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//catalytic activity//ATP binding -- -- KOG0369 Pyruvate carboxylase Cluster-8309.28718 BF_2 218.01 2.18 4480 642916588 XP_008191804.1 545 1.9e-52 PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum]>gi|642916590|ref|XP_008191810.1| PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12597 AIR1_2 protein AIR1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12597 A1L2T6 239 2.3e-18 Zinc finger CCHC domain-containing protein 7 OS=Xenopus laevis GN=zcchc7 PE=2 SV=2 PF06331 Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated -- -- GO:0000439 core TFIIH complex KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.28719 BF_2 112.00 3.40 1666 642916638 XP_970958.2 1851 2.5e-204 PREDICTED: glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02434 gatB, PET112 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02434 B0W3H3 1386 8.6e-152 Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial OS=Culex quinquefasciatus GN=CPIJ001717 PE=3 SV=1 PF02637//PF02934 GatB domain//GatB/GatE catalytic domain -- -- GO:0016884//GO:0016874 carbon-nitrogen ligase activity, with glutamine as amido-N-donor//ligase activity -- -- KOG2438 Glutamyl-tRNA amidotransferase subunit B Cluster-8309.28721 BF_2 89.00 0.92 4326 642919375 XP_008191845.1 3442 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 5.1e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF07714//PF00069//PF01325//PF13895//PF02480 Protein tyrosine kinase//Protein kinase domain//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0006468 protein phosphorylation GO:0005524//GO:0003677//GO:0005515//GO:0004672 ATP binding//DNA binding//protein binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.28722 BF_2 24.21 1.12 1192 270004583 EFA01031.1 622 5.8e-62 hypothetical protein TcasGA2_TC003947 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 503 1.5e-49 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.28726 BF_2 38.11 1.17 1651 815820103 XP_012231256.1 188 1.7e-11 PREDICTED: THAP domain-containing protein 5-like [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13851//PF05485//PF04977 Growth-arrest specific micro-tubule binding//THAP domain//Septum formation initiator GO:0007049//GO:0048870 cell cycle//cell motility GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.28729 BF_2 790.23 8.87 4016 270012816 EFA09264.1 1894 6.2e-209 matrix metalloproteinase 2 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q3U435 485 6.2e-47 Matrix metalloproteinase-25 OS=Mus musculus GN=Mmp25 PE=2 SV=1 PF02691//PF00413//PF10462//PF07998//PF01400 Vacuolating cyotoxin//Matrixin//Peptidase M66//Peptidase family M54//Astacin (Peptidase family M12A) GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012//GO:0005576 extracellular matrix//extracellular region -- -- Cluster-8309.28730 BF_2 9.00 0.31 1507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28731 BF_2 72.00 7.93 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28732 BF_2 301.51 5.32 2660 642914785 XP_008190351.1 1898 1.4e-209 PREDICTED: LIM domain-binding protein 2 isoform X6 [Tribolium castaneum] 642914784 XM_008192129.1 927 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X6, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 Q9W676 1309 1.2e-142 LIM domain-binding protein 2 OS=Gallus gallus GN=LDB2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.28733 BF_2 85.23 1.15 3400 642914785 XP_008190351.1 1898 1.8e-209 PREDICTED: LIM domain-binding protein 2 isoform X6 [Tribolium castaneum] 642914784 XM_008192129.1 947 0 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X6, mRNA K15617 LDB1 LIM domain-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15617 Q9W676 1309 1.5e-142 LIM domain-binding protein 2 OS=Gallus gallus GN=LDB2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2181 LIM domain binding protein LDB1/NLI/CLIM Cluster-8309.28734 BF_2 481.13 3.21 6562 91077990 XP_968879.1 2384 1.5e-265 PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp3 [Tribolium castaneum]>gi|270001423|gb|EEZ97870.1| hypothetical protein TcasGA2_TC000245 [Tribolium castaneum] 642914786 XM_008192130.1 262 6.76895e-132 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K12843 PRPF3, PRP3 U4/U6 small nuclear ribonucleoprotein PRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K12843 Q922U1 1295 1.2e-140 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Mus musculus GN=Prpf3 PE=2 SV=1 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2769 Putative u4/u6 small nuclear ribonucleoprotein Cluster-8309.28737 BF_2 17.78 0.62 1481 642930342 XP_008196356.1 862 1.1e-89 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 273 1.15217e-138 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- Q6PH08 136 6.7e-07 ERC protein 2 OS=Mus musculus GN=Erc2 PE=2 SV=2 PF10473//PF10174 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//RIM-binding protein of the cytomatrix active zone -- -- GO:0042803//GO:0045502//GO:0008134 protein homodimerization activity//dynein binding//transcription factor binding GO:0030286//GO:0048786//GO:0005667 dynein complex//presynaptic active zone//transcription factor complex -- -- Cluster-8309.28738 BF_2 4.00 0.63 552 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28739 BF_2 726.71 16.64 2114 646700389 KDR10550.1 1766 2.3e-194 V-type proton ATPase subunit C [Zootermopsis nevadensis] 571527272 XM_006562096.1 219 1.72837e-108 PREDICTED: Apis mellifera vacuolar H[+] ATPase 44kD C subunit (Vha44), transcript variant X2, mRNA K02148 ATPeV1C, ATP6C V-type H+-transporting ATPase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02148 Q9U5N1 1628 9.4e-180 V-type proton ATPase subunit C OS=Manduca sexta PE=2 SV=1 PF04513//PF03223//PF04799 Baculovirus polyhedron envelope protein, PEP, C terminus//V-ATPase subunit C//fzo-like conserved region GO:0015991//GO:0015992//GO:0008053 ATP hydrolysis coupled proton transport//proton transport//mitochondrial fusion GO:0003924//GO:0005198//GO:0015078 GTPase activity//structural molecule activity//hydrogen ion transmembrane transporter activity GO:0019031//GO:0033180//GO:0019028//GO:0016021//GO:0005741 viral envelope//proton-transporting V-type ATPase, V1 domain//viral capsid//integral component of membrane//mitochondrial outer membrane KOG2909 Vacuolar H+-ATPase V1 sector, subunit C Cluster-8309.28740 BF_2 20.65 0.38 2563 270007381 EFA03829.1 1855 1.3e-204 hypothetical protein TcasGA2_TC013944 [Tribolium castaneum] -- -- -- -- -- K19192 SAP130 histone deacetylase complex subunit SAP130 http://www.genome.jp/dbget-bin/www_bget?ko:K19192 Q8BIH0 293 7.2e-25 Histone deacetylase complex subunit SAP130 OS=Mus musculus GN=Sap130 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28742 BF_2 19.69 0.45 2124 642918767 XP_008191575.1 728 5.3e-74 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 380 4.9e-35 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.28743 BF_2 502.62 15.41 1652 91090466 XP_966605.1 1746 3.7e-192 PREDICTED: macrophage erythroblast attacher [Tribolium castaneum] -- -- -- -- -- K18624 MAEA, EMP macrophage erythroblast attacher http://www.genome.jp/dbget-bin/www_bget?ko:K18624 Q5F398 1163 6.1e-126 Macrophage erythroblast attacher OS=Gallus gallus GN=MAEA PE=2 SV=1 PF08513//PF06291 LisH//Bor protein -- -- GO:0005515 protein binding GO:0009279 cell outer membrane KOG0396 Uncharacterized conserved protein Cluster-8309.28745 BF_2 5.64 23.84 258 642913374 XP_008195452.1 423 1.5e-39 PREDICTED: uncharacterized protein LOC657396 isoform X1 [Tribolium castaneum]>gi|642913376|ref|XP_008195457.1| PREDICTED: uncharacterized protein LOC657396 isoform X1 [Tribolium castaneum] 195480065 XM_002101088.1 121 5.62518e-55 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.28746 BF_2 52.92 0.35 6542 642921466 XP_008192880.1 3990 0.0e+00 PREDICTED: transient receptor potential-gamma protein [Tribolium castaneum] 194884299 XM_001976197.1 386 0 Drosophila erecta GG20120 (Dere\GG20120), mRNA K05328 TRPCN transient receptor potential cation channel subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05328 Q9VJJ7 3322 0.0e+00 Transient receptor potential-gamma protein OS=Drosophila melanogaster GN=Trpgamma PE=1 SV=2 PF13606//PF09726//PF04692//PF00520 Ankyrin repeat//Transmembrane protein//Platelet-derived growth factor, N terminal region//Ion transport protein GO:0006811//GO:0007165//GO:0040007//GO:0055085//GO:0008283 ion transport//signal transduction//growth//transmembrane transport//cell proliferation GO:0005216//GO:0008083//GO:0005515 ion channel activity//growth factor activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.28747 BF_2 461.00 8.40 2582 642920873 XP_008192595.1 2587 1.8e-289 PREDICTED: protein turtle isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q967D7 903 1.3e-95 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF16656//PF00041//PF13895 Tissue factor//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.28750 BF_2 3.00 1.35 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28752 BF_2 408.82 9.48 2091 478262708 ENN81255.1 592 3.1e-58 hypothetical protein YQE_02349, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1KKR9 422 6.5e-40 Protein lunapark-B OS=Takifugu rubripes GN=lnpb PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2846 Predicted membrane protein Cluster-8309.28753 BF_2 1.00 6.28 246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28755 BF_2 1248.85 36.44 1721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28756 BF_2 33.99 1.31 1370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28760 BF_2 74.81 0.93 3636 642924494 XP_008194318.1 1947 4.0e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 9.1e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.28761 BF_2 37.11 0.49 3453 642924494 XP_008194318.1 1947 3.8e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 8.6e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.28762 BF_2 819.39 15.78 2460 731275672 XP_010606850.1 328 1.5e-27 PREDICTED: macrophage mannose receptor 1-like [Fukomys damarensis]>gi|676265405|gb|KFO21624.1| Macrophage mannose receptor 1 [Fukomys damarensis] -- -- -- -- -- -- -- -- -- P22897 252 4.0e-20 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF02944//PF07740 BESS motif//Ion channel inhibitory toxin GO:0006810//GO:0009405 transport//pathogenesis GO:0003677//GO:0008200 DNA binding//ion channel inhibitor activity GO:0005576 extracellular region KOG4297 C-type lectin Cluster-8309.28763 BF_2 105.87 0.91 5166 642934648 XP_972393.2 2127 7.7e-236 PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934650|ref|XP_008197751.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934652|ref|XP_008197752.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96NJ5 550 2.3e-54 Kelch-like protein 32 OS=Homo sapiens GN=KLHL32 PE=2 SV=2 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28766 BF_2 143.64 2.07 3193 91088135 XP_970927.1 2643 7.0e-296 PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum]>gi|642931216|ref|XP_008196487.1| PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum] -- -- -- -- -- K14015 NPLOC4, NPL4 nuclear protein localization protein 4 homolog http://www.genome.jp/dbget-bin/www_bget?ko:K14015 Q9VBP9 1974 1.1e-219 Nuclear protein localization protein 4 homolog OS=Drosophila melanogaster GN=Npl4 PE=1 SV=3 PF02565//PF15957//PF00641 Recombination protein O C terminal//Commissureless//Zn-finger in Ran binding protein and others GO:0006310//GO:0007411//GO:0006281 DNA recombination//axon guidance//DNA repair GO:0008270 zinc ion binding -- -- KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4) Cluster-8309.28769 BF_2 156.00 6.53 1286 91085985 XP_972080.1 729 2.5e-74 PREDICTED: RNA-binding motif protein, X-linked 2 [Tribolium castaneum]>gi|270010180|gb|EFA06628.1| hypothetical protein TcasGA2_TC009547 [Tribolium castaneum] -- -- -- -- -- K13107 RBMX2, IST3 RNA-binding motif protein, X-linked 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13107 B0BN49 523 7.8e-52 RNA-binding motif protein, X-linked 2 OS=Rattus norvegicus GN=Rbmx2 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0126 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.28773 BF_2 23.00 0.43 2503 189233729 XP_970857.2 1013 5.6e-107 PREDICTED: protein giant-lens [Tribolium castaneum] -- -- -- -- -- K02104 ARGOS giant-lens protein precursor (argos protein) http://www.genome.jp/dbget-bin/www_bget?ko:K02104 Q00805 564 2.7e-56 Protein giant-lens OS=Drosophila melanogaster GN=aos PE=1 SV=2 PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.28774 BF_2 6974.25 212.83 1658 91095259 XP_973683.1 1207 1.2e-129 PREDICTED: senecionine N-oxygenase [Tribolium castaneum]>gi|270017047|gb|EFA13493.1| hypothetical protein TcasGA2_TC016303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MP06 524 7.7e-52 Senecionine N-oxygenase OS=Tyria jacobaeae GN=sno1 PE=1 SV=1 PF01266//PF05834//PF00070//PF01210//PF01134//PF00743//PF07992//PF01494//PF02789//PF01593 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Glucose inhibited division protein A//Flavin-binding monooxygenase-like//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Cytosol aminopeptidase family, N-terminal domain//Flavin containing amine oxidoreductase GO:0046168//GO:0006508//GO:0016117//GO:0008033//GO:0055114 glycerol-3-phosphate catabolic process//proteolysis//carotenoid biosynthetic process//tRNA processing//oxidation-reduction process GO:0004499//GO:0050661//GO:0071949//GO:0016705//GO:0016491//GO:0016616//GO:0051287//GO:0050660//GO:0004177 N,N-dimethylaniline monooxygenase activity//NADP binding//FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//flavin adenine dinucleotide binding//aminopeptidase activity GO:0005622 intracellular -- -- Cluster-8309.28775 BF_2 5074.70 62.64 3676 91095259 XP_973683.1 1213 5.3e-130 PREDICTED: senecionine N-oxygenase [Tribolium castaneum]>gi|270017047|gb|EFA13493.1| hypothetical protein TcasGA2_TC016303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MP06 479 2.8e-46 Senecionine N-oxygenase OS=Tyria jacobaeae GN=sno1 PE=1 SV=1 PF02789//PF00070//PF01593//PF01266//PF00743//PF05834//PF07992 Cytosol aminopeptidase family, N-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Flavin-binding monooxygenase-like//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0006508//GO:0016117 oxidation-reduction process//proteolysis//carotenoid biosynthetic process GO:0050660//GO:0004177//GO:0016491//GO:0004499//GO:0050661//GO:0016705 flavin adenine dinucleotide binding//aminopeptidase activity//oxidoreductase activity//N,N-dimethylaniline monooxygenase activity//NADP binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005622 intracellular -- -- Cluster-8309.28776 BF_2 74.00 8.55 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28777 BF_2 6.00 1.48 456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28779 BF_2 921.93 18.19 2407 91076592 XP_968333.1 932 1.3e-97 PREDICTED: charged multivesicular body protein 5 [Tribolium castaneum]>gi|270002380|gb|EEZ98827.1| hypothetical protein TcasGA2_TC004434 [Tribolium castaneum] 642912650 XM_963240.2 181 2.6241e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K12198 CHMP5, VPS60 charged multivesicular body protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12198 Q9VVI9 706 8.8e-73 Charged multivesicular body protein 5 OS=Drosophila melanogaster GN=Vps60 PE=1 SV=2 PF07544//PF00462//PF01920//PF03357//PF04871//PF04632//PF16326//PF04111//PF05531 RNA polymerase II transcription mediator complex subunit 9//Glutaredoxin//Prefoldin subunit//Snf7//Uso1 / p115 like vesicle tethering protein, C terminal region//Fusaric acid resistance protein family//ABC transporter C-terminal domain//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein GO:0006810//GO:0006886//GO:0006914//GO:0006357//GO:0006118//GO:0015031//GO:0007034//GO:0006457//GO:0045454 transport//intracellular protein transport//autophagy//regulation of transcription from RNA polymerase II promoter//obsolete electron transport//protein transport//vacuolar transport//protein folding//cell redox homeostasis GO:0008565//GO:0051082//GO:0003677//GO:0001104//GO:0015035//GO:0009055 protein transporter activity//unfolded protein binding//DNA binding//RNA polymerase II transcription cofactor activity//protein disulfide oxidoreductase activity//electron carrier activity GO:0019028//GO:0016272//GO:0005737//GO:0005886//GO:0016592//GO:0016020 viral capsid//prefoldin complex//cytoplasm//plasma membrane//mediator complex//membrane KOG1655 Protein involved in vacuolar protein sorting Cluster-8309.28782 BF_2 85.10 1.68 2405 189242134 XP_968235.2 1493 1.2e-162 PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 7.3e-112 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF00515//PF05118//PF13176//PF13414//PF04812//PF13181//PF05470//PF04147//PF04557//PF13174 Tetratricopeptide repeat//Aspartyl/Asparaginyl beta-hydroxylase//Tetratricopeptide repeat//TPR repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//Tetratricopeptide repeat//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Nop14-like family//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//Tetratricopeptide repeat GO:0045893//GO:0006425//GO:0006413//GO:0018193//GO:0006446 positive regulation of transcription, DNA-templated//glutaminyl-tRNA aminoacylation//translational initiation//peptidyl-amino acid modification//regulation of translational initiation GO:0000166//GO:0003743//GO:0005524//GO:0004819//GO:0031369//GO:0005515 nucleotide binding//translation initiation factor activity//ATP binding//glutamine-tRNA ligase activity//translation initiation factor binding//protein binding GO:0005737//GO:0032040//GO:0005840//GO:0005852//GO:0005634 cytoplasm//small-subunit processome//ribosome//eukaryotic translation initiation factor 3 complex//nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.28784 BF_2 7.01 2.41 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28785 BF_2 226.00 11.16 1134 91082333 XP_974678.1 805 3.3e-83 PREDICTED: sugar transporter SWEET1 [Tribolium castaneum]>gi|270008305|gb|EFA04753.1| hypothetical protein TcasGA2_TC030574 [Tribolium castaneum] -- -- -- -- -- K15382 SLC50A, SWEET solute carrier family 50 (sugar transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K15382 Q7JVE7 590 1.2e-59 Sugar transporter SWEET1 OS=Drosophila melanogaster GN=slv PE=1 SV=1 PF03083//PF02293 Sugar efflux transporter for intercellular exchange//AmiS/UreI family transporter GO:0006310//GO:0006810//GO:0008643 DNA recombination//transport//carbohydrate transport -- -- GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane KOG1623 Multitransmembrane protein Cluster-8309.28787 BF_2 429.76 8.49 2404 642915809 XP_008200087.1 1148 1.2e-122 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 466 5.9e-45 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.28789 BF_2 33.15 2.96 756 91092902 XP_971056.1 742 4.5e-76 PREDICTED: N-acetyltransferase 9-like protein [Tribolium castaneum]>gi|270003097|gb|EEZ99544.1| hypothetical protein TcasGA2_TC000126 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SLC8 468 1.1e-45 N-acetyltransferase 9-like protein OS=Nematostella vectensis GN=nat9 PE=3 SV=1 PF13302 Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG4135 Predicted phosphoglucosamine acetyltransferase Cluster-8309.2879 BF_2 13.09 1.51 649 546677206 ERL88085.1 201 2.1e-13 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28792 BF_2 271.03 7.57 1785 91081985 XP_968673.1 604 1.1e-59 PREDICTED: protein LZIC [Tribolium castaneum]>gi|270007372|gb|EFA03820.1| hypothetical protein TcasGA2_TC013935 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DHH7 386 8.3e-36 Protein LZIC OS=Danio rerio GN=lzic PE=1 SV=1 PF06384//PF04632 Beta-catenin-interacting protein ICAT//Fusaric acid resistance protein family GO:0006810 transport GO:0008013 beta-catenin binding GO:0005886//GO:0016342 plasma membrane//catenin complex -- -- Cluster-8309.28795 BF_2 16.21 0.42 1885 478263077 ENN81477.1 469 5.1e-44 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10729 Cell division activator CedA GO:0051301 cell division GO:0003677 DNA binding -- -- -- -- Cluster-8309.28800 BF_2 5.02 0.68 596 642933931 XP_008197572.1 383 1.5e-34 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 141 7.1e-08 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28803 BF_2 4.00 0.70 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28805 BF_2 366.69 13.21 1448 642931814 XP_008196744.1 1106 5.3e-118 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 804 2.3e-84 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.28806 BF_2 997.00 33.03 1550 91095041 XP_971778.1 1382 5.6e-150 PREDICTED: cysteine-rich with EGF-like domain protein 2 [Tribolium castaneum]>gi|270014762|gb|EFA11210.1| hypothetical protein TcasGA2_TC005174 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXF6 729 1.2e-75 Cysteine-rich with EGF-like domain protein 2 OS=Danio rerio GN=creld2 PE=2 SV=2 PF07645//PF06298 Calcium-binding EGF domain//Photosystem II protein Y (PsbY) GO:0015979 photosynthesis GO:0005509//GO:0030145 calcium ion binding//manganese ion binding GO:0016021//GO:0009523 integral component of membrane//photosystem II KOG4260 Uncharacterized conserved protein Cluster-8309.28807 BF_2 11.59 0.41 1463 91078688 XP_971079.1 929 1.8e-97 PREDICTED: pentatricopeptide repeat-containing protein 1, mitochondrial [Tribolium castaneum]>gi|270004076|gb|EFA00524.1| hypothetical protein TcasGA2_TC003389 [Tribolium castaneum] -- -- -- -- -- K17710 PTCD1 pentatricopeptide repeat domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17710 O75127 465 4.7e-45 Pentatricopeptide repeat-containing protein 1, mitochondrial OS=Homo sapiens GN=PTCD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4197 FOG: PPR repeat Cluster-8309.28808 BF_2 8.00 0.39 1143 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28809 BF_2 280.94 3.24 3912 478251380 ENN71846.1 1036 1.9e-109 hypothetical protein YQE_11464, partial [Dendroctonus ponderosae] -- -- -- -- -- K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 Q7ZXE9 429 1.9e-40 Testin OS=Xenopus laevis GN=tes PE=2 SV=1 PF00412//PF06297 LIM domain//PET Domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.28812 BF_2 40.00 5.75 578 -- -- -- -- -- 642914215 XM_968004.2 43 3.11443e-11 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC661872), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28813 BF_2 2139.38 46.79 2200 269995911 NP_001161778.1 1536 1.1e-167 yellow-c precursor [Tribolium castaneum]>gi|270014214|gb|EFA10662.1| hypothetical protein TcasGA2_TC016299 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02437 819 6.3e-86 Protein yellow OS=Drosophila subobscura GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28817 BF_2 189.57 36.55 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28818 BF_2 765.57 5.80 5812 478257262 ENN77425.1 4009 0.0e+00 hypothetical protein YQE_06250, partial [Dendroctonus ponderosae]>gi|546683816|gb|ERL93569.1| hypothetical protein D910_10857 [Dendroctonus ponderosae] 801384853 XM_012200272.1 35 9.25356e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.4e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF13949//PF00102//PF00782//PF04632 ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Fusaric acid resistance protein family GO:0006570//GO:0006810//GO:0006470 tyrosine metabolic process//transport//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding GO:0005886 plasma membrane KOG2220 Predicted signal transduction protein Cluster-8309.28819 BF_2 108.68 0.83 5791 478257262 ENN77425.1 4013 0.0e+00 hypothetical protein YQE_06250, partial [Dendroctonus ponderosae]>gi|546683816|gb|ERL93569.1| hypothetical protein D910_10857 [Dendroctonus ponderosae] 801384853 XM_012200272.1 35 9.21992e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.4e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF04632//PF00782//PF13949//PF00102 Fusaric acid resistance protein family//Dual specificity phosphatase, catalytic domain//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase GO:0006470//GO:0006570//GO:0006810 protein dephosphorylation//tyrosine metabolic process//transport GO:0008138//GO:0005515//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity GO:0005886 plasma membrane KOG2220 Predicted signal transduction protein Cluster-8309.2882 BF_2 2.00 0.35 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.28820 BF_2 529.36 8.38 2929 332374228 AEE62255.1 922 2.3e-96 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D3D0 225 6.4e-17 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28822 BF_2 131.21 0.55 10328 642935247 XP_008197929.1 5669 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 1017 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1750 3.3e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05506//PF13443//PF16656//PF00041//PF13895 Domain of unknown function (DUF756)//Cro/C1-type HTH DNA-binding domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0016042//GO:0006771//GO:0009395//GO:0019497 lipid catabolic process//riboflavin metabolic process//phospholipid catabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0043565//GO:0004629//GO:0046872//GO:0005515 acid phosphatase activity//sequence-specific DNA binding//phospholipase C activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.28823 BF_2 224.11 5.26 2069 546671283 ERL83661.1 930 1.9e-97 hypothetical protein D910_00828 [Dendroctonus ponderosae]>gi|546671285|gb|ERL83662.1| hypothetical protein D910_00829 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00637 Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- -- -- -- -- Cluster-8309.28826 BF_2 289.69 8.95 1641 91088651 XP_974484.1 1325 2.4e-143 PREDICTED: beta-1,4-galactosyltransferase 4 [Tribolium castaneum]>gi|270012269|gb|EFA08717.1| hypothetical protein TcasGA2_TC006388 [Tribolium castaneum] -- -- -- -- -- K07968 B4GALT3 beta-1,4-galactosyltransferase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07968 Q9GUM2 694 1.5e-71 Beta-1,4-N-acetylgalactosaminyltransferase bre-4 OS=Caenorhabditis elegans GN=bre-4 PE=1 SV=1 PF04421 Mss4 protein GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.28827 BF_2 227.25 2.49 4100 91077400 XP_975316.1 3136 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X2 [Tribolium castaneum]>gi|270002116|gb|EEZ98563.1| hypothetical protein TcasGA2_TC001074 [Tribolium castaneum] 755870656 XM_005181954.2 137 1.29464e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 Q63531 2117 3.6e-236 Ribosomal protein S6 kinase alpha-1 OS=Rattus norvegicus GN=Rps6ka1 PE=1 SV=1 PF07714//PF00433//PF00069//PF06293 Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0000287//GO:0004672//GO:0004674//GO:0016773 ATP binding//magnesium ion binding//protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.28828 BF_2 549.24 7.03 3556 817209795 XP_012280960.1 2388 2.9e-266 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Orussus abietinus] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q6WQJ1 1365 5.0e-149 Sn1-specific diacylglycerol lipase alpha OS=Mus musculus GN=Dagla PE=1 SV=2 PF02411//PF01764//PF07168 MerT mercuric transport protein//Lipase (class 3)//Ureide permease GO:0071705//GO:0015694//GO:0006629 nitrogen compound transport//mercury ion transport//lipid metabolic process GO:0015097 mercury ion transmembrane transporter activity GO:0016020 membrane KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.28829 BF_2 108.41 1.34 3660 -- -- -- -- -- 642912790 XM_008203032.1 91 4.30171e-37 PREDICTED: Tribolium castaneum max-interacting protein 1-like (LOC100142502), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2883 BF_2 12.68 0.92 865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.28830 BF_2 31.65 0.42 3445 817209795 XP_012280960.1 2392 9.6e-267 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Orussus abietinus] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q6WQJ1 1369 1.7e-149 Sn1-specific diacylglycerol lipase alpha OS=Mus musculus GN=Dagla PE=1 SV=2 PF02411//PF01764//PF07168 MerT mercuric transport protein//Lipase (class 3)//Ureide permease GO:0006629//GO:0015694//GO:0071705 lipid metabolic process//mercury ion transport//nitrogen compound transport GO:0015097 mercury ion transmembrane transporter activity GO:0016020 membrane KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.28831 BF_2 34.57 0.54 2978 817209795 XP_012280960.1 2209 1.4e-245 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Orussus abietinus] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q6WQJ1 1261 4.8e-137 Sn1-specific diacylglycerol lipase alpha OS=Mus musculus GN=Dagla PE=1 SV=2 PF02411//PF01764//PF07168 MerT mercuric transport protein//Lipase (class 3)//Ureide permease GO:0006629//GO:0071705//GO:0015694 lipid metabolic process//nitrogen compound transport//mercury ion transport GO:0015097 mercury ion transmembrane transporter activity GO:0016020 membrane KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.28834 BF_2 252.37 1.96 5675 91091388 XP_973447.1 1899 2.3e-209 PREDICTED: sorting nexin-29 isoform X1 [Tribolium castaneum]>gi|270014165|gb|EFA10613.1| hypothetical protein TcasGA2_TC012874 [Tribolium castaneum] -- -- -- -- -- K17935 SNX29 sorting nexin-29 http://www.genome.jp/dbget-bin/www_bget?ko:K17935 Q08DX0 463 3.1e-44 Sorting nexin-29 OS=Bos taurus GN=SNX29 PE=2 SV=1 PF00957//PF04977//PF00787 Synaptobrevin//Septum formation initiator//PX domain GO:0007049//GO:0016192 cell cycle//vesicle-mediated transport GO:0035091 phosphatidylinositol binding GO:0016021 integral component of membrane KOG4381 RUN domain-containing protein Cluster-8309.28838 BF_2 104.29 2.18 2288 642938529 XP_967703.2 2004 6.2e-222 PREDICTED: RUN domain-containing protein 1-like [Tribolium castaneum]>gi|270015593|gb|EFA12041.1| hypothetical protein TcasGA2_TC001458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96C34 819 6.6e-86 RUN domain-containing protein 1 OS=Homo sapiens GN=RUNDC1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3759 Uncharacterized RUN domain protein Cluster-8309.28839 BF_2 100.67 4.55 1212 91086565 XP_967047.1 816 1.9e-84 PREDICTED: zinc finger protein-like 1 [Tribolium castaneum]>gi|270009770|gb|EFA06218.1| hypothetical protein TcasGA2_TC009067 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VFM0 368 6.9e-34 Zinc finger protein-like 1 OS=Xenopus tropicalis GN=zfpl1 PE=2 SV=1 PF13639//PF00628//PF00643 Ring finger domain//PHD-finger//B-box zinc finger -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005622 intracellular KOG3970 Predicted E3 ubiquitin ligase Cluster-8309.28841 BF_2 31.00 1.70 1052 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28842 BF_2 236.00 10.31 1245 91089781 XP_967683.1 889 6.6e-93 PREDICTED: 39S ribosomal protein L16, mitochondrial [Tribolium castaneum]>gi|91094701|ref|XP_969519.1| PREDICTED: 39S ribosomal protein L16, mitochondrial [Tribolium castaneum]>gi|270013618|gb|EFA10066.1| hypothetical protein TcasGA2_TC012240 [Tribolium castaneum]>gi|270016519|gb|EFA12965.1| hypothetical protein TcasGA2_TC001416 [Tribolium castaneum] -- -- -- -- -- K02878 RP-L16, MRPL16, rplP large subunit ribosomal protein L16 http://www.genome.jp/dbget-bin/www_bget?ko:K02878 Q9NX20 493 2.3e-48 39S ribosomal protein L16, mitochondrial OS=Homo sapiens GN=MRPL16 PE=1 SV=1 PF00252//PF02297 Ribosomal protein L16p/L10e//Cytochrome oxidase c subunit VIb GO:0006412//GO:0006123//GO:0042254//GO:0015992 translation//mitochondrial electron transport, cytochrome c to oxygen//ribosome biogenesis//proton transport GO:0004129//GO:0019843//GO:0003735 cytochrome-c oxidase activity//rRNA binding//structural constituent of ribosome GO:0045277//GO:0005739//GO:0005840 respiratory chain complex IV//mitochondrion//ribosome KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.28845 BF_2 168.00 13.76 798 91080375 XP_975028.1 563 2.7e-55 PREDICTED: single-stranded DNA-binding protein, mitochondrial [Tribolium castaneum]>gi|270005728|gb|EFA02176.1| hypothetical protein TcasGA2_TC007832 [Tribolium castaneum] -- -- -- -- -- K03111 ssb single-strand DNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03111 P54622 407 1.4e-38 Single-stranded DNA-binding protein, mitochondrial OS=Drosophila melanogaster GN=mtSSB PE=1 SV=2 PF00436 Single-strand binding protein family GO:0006260 DNA replication GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.28852 BF_2 5.00 0.50 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28854 BF_2 136.73 5.20 1388 642911402 XP_972355.3 1344 1.3e-145 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKA4 347 2.1e-31 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.28855 BF_2 75.34 1.21 2892 338224398 AEI88080.1 332 6.0e-28 midline fasciclin [Scylla paramamosain] 338224397 HM217842.1 193 6.741e-94 Scylla paramamosain isolate 1 midline fasciclin mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28856 BF_2 82.86 0.46 7799 642935646 XP_008198097.1 2607 2.5e-291 PREDICTED: rho GTPase-activating protein 21-B isoform X6 [Tribolium castaneum] 642935647 XM_008199876.1 234 2.95821e-116 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.3e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF11973//PF00595//PF00620//PF13180 Glycolipid transfer protein (GLTP)//NQRA C-terminal domain//PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//PDZ domain GO:0046836//GO:0007165//GO:0055114//GO:0006118 glycolipid transport//signal transduction//oxidation-reduction process//obsolete electron transport GO:0005515//GO:0017089//GO:0016655//GO:0051861 protein binding//glycolipid transporter activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//glycolipid binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.28858 BF_2 58.82 11.29 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2886 BF_2 9.06 0.40 1224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF07776 FYVE zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.28860 BF_2 127.16 2.45 2462 642919569 XP_008191926.1 1099 5.9e-117 PREDICTED: protein angel homolog 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 613 5.5e-62 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.28862 BF_2 46.83 0.76 2878 478251404 ENN71870.1 492 1.7e-46 hypothetical protein YQE_11485, partial [Dendroctonus ponderosae] 449102215 JX081307.1 150 5.37227e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 9.3e-45 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.28864 BF_2 1935.92 84.90 1241 91081359 XP_971395.1 1355 6.1e-147 PREDICTED: tumor suppressor candidate 3 [Tribolium castaneum]>gi|270005188|gb|EFA01636.1| hypothetical protein TcasGA2_TC007206 [Tribolium castaneum] 571501133 XM_395605.5 180 4.79855e-87 PREDICTED: Apis mellifera magnesium transporter protein 1-like (LOC412141), mRNA K12669 OST3, OST6 oligosaccharyltransferase complex subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K12669 Q8BTV1 1013 1.1e-108 Tumor suppressor candidate 3 OS=Mus musculus GN=Tusc3 PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2603 Oligosaccharyltransferase, gamma subunit Cluster-8309.28866 BF_2 247.81 4.93 2392 270001539 EEZ97986.1 2022 5.3e-224 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 5.14831e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1093 1.2e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.28868 BF_2 6.53 3.23 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28869 BF_2 5.47 2.56 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28871 BF_2 426.70 2.82 6611 642919657 XP_008192010.1 2486 2.3e-277 PREDICTED: kinesin light chain isoform X2 [Tribolium castaneum]>gi|270005876|gb|EFA02324.1| hypothetical protein TcasGA2_TC007992 [Tribolium castaneum] 817205684 XM_012423337.1 333 2.31786e-171 PREDICTED: Orussus abietinus kinesin light chain (LOC105698786), transcript variant X2, mRNA K10407 KLC kinesin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10407 P46824 1708 1.6e-188 Kinesin light chain OS=Drosophila melanogaster GN=Klc PE=1 SV=1 PF00637//PF13414//PF11365//PF13176//PF03836//PF00515//PF13374//PF13174//PF01239//PF13181//PF06156 Region in Clathrin and VPS//TPR repeat//Protein of unknown function (DUF3166)//Tetratricopeptide repeat//RasGAP C-terminus//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Protein prenyltransferase alpha subunit repeat//Tetratricopeptide repeat//Protein of unknown function (DUF972) GO:0007264//GO:0006260//GO:0007017//GO:0006886//GO:0016192//GO:0018342//GO:0010506 small GTPase mediated signal transduction//DNA replication//microtubule-based process//intracellular protein transport//vesicle-mediated transport//protein prenylation//regulation of autophagy GO:0008318//GO:0003777//GO:0005515//GO:0005096 protein prenyltransferase activity//microtubule motor activity//protein binding//GTPase activator activity GO:0005615//GO:0005871//GO:0005874 extracellular space//kinesin complex//microtubule KOG1840 Kinesin light chain Cluster-8309.28873 BF_2 1975.84 10.80 7941 642924213 XP_972838.2 5278 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum] 807042282 XM_004536355.2 42 1.62597e-09 PREDICTED: Ceratitis capitata GPI transamidase component PIG-T (LOC101449963), mRNA K06530 CD109 CD109 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06530 Q6YHK3 1504 8.5e-165 CD109 antigen OS=Homo sapiens GN=CD109 PE=1 SV=2 PF04113//PF00432//PF00207//PF07678//PF06756//PF01835//PF07677 Gpi16 subunit, GPI transamidase component//Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//A-macroglobulin complement component//Chorion protein S19 C-terminal//MG2 domain//A-macroglobulin receptor GO:0016255//GO:0007275 attachment of GPI anchor to protein//multicellular organismal development GO:0004866//GO:0003824 endopeptidase inhibitor activity//catalytic activity GO:0042600//GO:0042765//GO:0005615//GO:0005576 chorion//GPI-anchor transamidase complex//extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.28875 BF_2 158.07 3.03 2467 642919825 XP_008192085.1 297 5.8e-24 PREDICTED: uncharacterized protein LOC103312661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.28876 BF_2 384.23 4.51 3854 642922650 XP_008193261.1 2300 5.0e-256 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X2 [Tribolium castaneum]>gi|270007151|gb|EFA03599.1| hypothetical protein TcasGA2_TC013686 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1660 3.3e-183 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF04097//PF00711 C2 domain//Nup93/Nic96//Beta defensin GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005576//GO:0005643 extracellular region//nuclear pore KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.28877 BF_2 191.52 1.24 6759 642932607 XP_008196920.1 1408 2.4e-152 PREDICTED: slowpoke-binding protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q8IPH9 476 1.2e-45 Slowpoke-binding protein OS=Drosophila melanogaster GN=Slob PE=1 SV=2 PF01799 [2Fe-2S] binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.28878 BF_2 192.16 6.27 1570 642932605 XP_008196919.1 1550 1.9e-169 PREDICTED: slowpoke-binding protein isoform X3 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q8IPH9 524 7.3e-52 Slowpoke-binding protein OS=Drosophila melanogaster GN=Slob PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28881 BF_2 82.43 9.22 661 91089491 XP_969723.1 538 1.8e-52 PREDICTED: U6 snRNA-associated Sm-like protein LSm7 [Tribolium castaneum] -- -- -- -- -- K12626 LSM7 U6 snRNA-associated Sm-like protein LSm7 http://www.genome.jp/dbget-bin/www_bget?ko:K12626 Q9UK45 433 1.1e-41 U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens GN=LSM7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1781 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.28882 BF_2 35.90 0.37 4384 642931601 XP_008196651.1 2197 5.0e-244 PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum]>gi|642931603|ref|XP_008196652.1| PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum] 170039524 XM_001847530.1 513 0 Culex quinquefasciatus eukaryotic translation initiation factor 2C 2, mRNA K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 1775 1.8e-196 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF03554//PF04810//PF02171 UL73 viral envelope glycoprotein//Sec23/Sec24 zinc finger//Piwi domain GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0030127//GO:0019031 COPII vesicle coat//viral envelope KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.28883 BF_2 3.00 0.84 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.28884 BF_2 521.00 10.67 2330 91076160 XP_966582.1 1288 6.7e-139 PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911736|ref|XP_008200719.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911739|ref|XP_008200720.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911741|ref|XP_008200721.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|270014726|gb|EFA11174.1| hypothetical protein TcasGA2_TC004781 [Tribolium castaneum] -- -- -- -- -- K04523 UBQLN, DSK2 ubiquilin http://www.genome.jp/dbget-bin/www_bget?ko:K04523 Q8R317 668 2.2e-68 Ubiquilin-1 OS=Mus musculus GN=Ubqln1 PE=1 SV=1 PF00240//PF03710//PF06559 Ubiquitin family//Glutamate-ammonia ligase adenylyltransferase//2'-deoxycytidine 5'-triphosphate deaminase (DCD) GO:0006206//GO:0006807//GO:0009394 pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//2'-deoxyribonucleotide metabolic process GO:0008829//GO:0008882//GO:0005515 dCTP deaminase activity//[glutamate-ammonia-ligase] adenylyltransferase activity//protein binding -- -- KOG0010 Ubiquitin-like protein Cluster-8309.28886 BF_2 405.43 4.44 4104 642911589 XP_008200663.1 794 2.3e-81 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 415 8.3e-39 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28887 BF_2 157.54 1.59 4439 642911589 XP_008200663.1 794 2.5e-81 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] 462386057 APGK01020367.1 60 8.9332e-20 Dendroctonus ponderosae Seq01020377, whole genome shotgun sequence -- -- -- -- A6MHQ4 362 1.3e-32 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28888 BF_2 237.91 2.22 4777 270010132 EFA06580.1 1966 3.3e-217 hypothetical protein TcasGA2_TC009492 [Tribolium castaneum] 795059302 XM_012017418.1 258 8.23256e-130 PREDICTED: Vollenhovia emeryi F-box/LRR-repeat protein 14 (LOC105564772), mRNA K10280 FBXL14 F-box and leucine-rich repeat protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K10280 Q8N1E6 1336 1.5e-145 F-box/LRR-repeat protein 14 OS=Homo sapiens GN=FBXL14 PE=1 SV=1 PF04091//PF00646//PF00560//PF01529//PF13516//PF13855//PF12937 Exocyst complex subunit Sec15-like//F-box domain//Leucine Rich Repeat//DHHC palmitoyltransferase//Leucine Rich repeat//Leucine rich repeat//F-box-like GO:0006904 vesicle docking involved in exocytosis GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0000145 exocyst KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.28891 BF_2 78.61 0.60 5734 642927195 XP_008195175.1 1633 1.6e-178 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28894 BF_2 409.55 1.74 10119 642938167 XP_008190994.1 245 2.6e-17 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0007186//GO:0006950 G-protein coupled receptor signaling pathway//response to stress GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.28895 BF_2 2.00 0.37 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28896 BF_2 1415.64 26.21 2547 91081197 XP_975607.1 1380 1.6e-149 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270005269|gb|EFA01717.1| hypothetical protein TcasGA2_TC007297 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 504 2.5e-49 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.28897 BF_2 89.00 6.14 894 642922166 XP_008193043.1 323 2.0e-27 PREDICTED: uncharacterized protein LOC103312926 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00258 134 6.9e-07 Tail-anchored protein insertion receptor WRB OS=Homo sapiens GN=WRB PE=1 SV=2 PF04420 CHD5-like protein GO:0071816 tail-anchored membrane protein insertion into ER membrane -- -- -- -- -- -- Cluster-8309.28899 BF_2 4.00 1.63 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28900 BF_2 315.80 8.46 1848 478257549 ENN77703.1 470 3.8e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 169 1.2e-10 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.28903 BF_2 2.00 0.66 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28904 BF_2 603.09 24.67 1310 642931818 XP_008196746.1 1127 1.8e-120 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] 551546037 XM_005760895.1 51 2.60602e-15 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 861 5.1e-91 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF00733//PF01507//PF00764//PF07722//PF02568 Asparagine synthase//Phosphoadenosine phosphosulfate reductase family//Arginosuccinate synthase//Peptidase C26//Thiamine biosynthesis protein (ThiI) GO:0006522//GO:0006541//GO:0008033//GO:0006526//GO:0008152//GO:0006529//GO:0006531//GO:0006560 alanine metabolic process//glutamine metabolic process//tRNA processing//arginine biosynthetic process//metabolic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process GO:0004066//GO:0003824//GO:0005524//GO:0004810//GO:0016787//GO:0004055 asparagine synthase (glutamine-hydrolyzing) activity//catalytic activity//ATP binding//tRNA adenylyltransferase activity//hydrolase activity//argininosuccinate synthase activity -- -- KOG1622 GMP synthase Cluster-8309.28907 BF_2 100.92 1.78 2661 270002150 EEZ98597.1 1422 2.2e-154 hypothetical protein TcasGA2_TC001116 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 955 1.3e-101 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728//PF13465 Glycosyl hydrolase family 20, catalytic domain//Zinc-finger double domain GO:0005975 carbohydrate metabolic process GO:0046872//GO:0004553 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.28908 BF_2 156.30 1.58 4427 642929609 XP_008195902.1 1940 3.2e-214 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UNN5 797 4.5e-83 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF00240//PF09230//PF09226 Ubiquitin family//DNA fragmentation factor 40 kDa//Restriction endonuclease HincII GO:0006309//GO:0006308//GO:0009307 apoptotic DNA fragmentation//DNA catabolic process//DNA restriction-modification system GO:0005515//GO:0009036//GO:0003677//GO:0016787 protein binding//Type II site-specific deoxyribonuclease activity//DNA binding//hydrolase activity GO:0005634//GO:0005737//GO:0009359 nucleus//cytoplasm//Type II site-specific deoxyribonuclease complex KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.28909 BF_2 203.93 7.92 1364 546682999 ERL92871.1 737 3.1e-75 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28910 BF_2 271.34 2.23 5380 642920483 XP_008192370.1 2715 5.3e-304 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K03680 EIF2B4 translation initiation factor eIF-2B subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K03680 Q63186 925 7.9e-98 Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1 PF00536//PF02601//PF01496//PF07647//PF01763//PF01008//PF02198 SAM domain (Sterile alpha motif)//Exonuclease VII, large subunit//V-type ATPase 116kDa subunit family//SAM domain (Sterile alpha motif)//Herpesvirus UL6 like//Initiation factor 2 subunit family//Sterile alpha motif (SAM)/Pointed domain GO:0006323//GO:0015992//GO:0006308//GO:0015991//GO:0044237 DNA packaging//proton transport//DNA catabolic process//ATP hydrolysis coupled proton transport//cellular metabolic process GO:0043565//GO:0015078//GO:0008855//GO:0005515 sequence-specific DNA binding//hydrogen ion transmembrane transporter activity//exodeoxyribonuclease VII activity//protein binding GO:0033179//GO:0009318//GO:0005634 proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex//nucleus KOG1467 Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) Cluster-8309.28911 BF_2 21.07 0.35 2824 546682999 ERL92871.1 726 1.2e-73 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28912 BF_2 42.44 0.31 6035 91088309 XP_969421.1 1779 2.0e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 808 3.3e-84 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF02254//PF05199//PF01266//PF07992//PF00732//PF05834 TrkA-N domain//GMC oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein GO:0006813//GO:0055114//GO:0016117 potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016705//GO:0016614 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.28913 BF_2 31.20 0.49 2935 189238157 XP_976123.2 1140 1.2e-121 PREDICTED: adiponectin receptor protein isoform X2 [Tribolium castaneum] 462291785 APGK01053980.1 177 5.36494e-85 Dendroctonus ponderosae Seq01053990, whole genome shotgun sequence K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 933 5.1e-99 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.28915 BF_2 199.00 3.20 2890 642920354 XP_008192311.1 338 1.2e-28 PREDICTED: uncharacterized protein LOC103312712 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28919 BF_2 23.00 0.50 2230 642936500 XP_008198463.1 455 2.5e-42 PREDICTED: uncharacterized protein LOC103312129 [Tribolium castaneum]>gi|270014115|gb|EFA10563.1| hypothetical protein TcasGA2_TC012819 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28920 BF_2 21.74 0.37 2750 478259251 ENN79153.1 288 7.2e-23 hypothetical protein YQE_04339, partial [Dendroctonus ponderosae]>gi|546678413|gb|ERL89036.1| hypothetical protein D910_06414 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02284 Cytochrome c oxidase subunit Va GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane -- -- Cluster-8309.28922 BF_2 437.00 10.42 2041 478259251 ENN79153.1 1512 6.3e-165 hypothetical protein YQE_04339, partial [Dendroctonus ponderosae]>gi|546678413|gb|ERL89036.1| hypothetical protein D910_06414 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B3N9E4 1018 4.9e-109 Protein kintoun OS=Drosophila erecta GN=Ppi20 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28925 BF_2 9.47 0.41 1251 270004137 EFA00585.1 432 6.5e-40 hypothetical protein TcasGA2_TC003455 [Tribolium castaneum] -- -- -- -- -- K14206 SLC15A1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14206 P36836 262 1.4e-21 Solute carrier family 15 member 1 OS=Oryctolagus cuniculus GN=SLC15A1 PE=2 SV=1 PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1237 H+/oligopeptide symporter Cluster-8309.28928 BF_2 1.00 4.96 253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28930 BF_2 203.00 2.29 3992 642925248 XP_008194481.1 1349 9.7e-146 PREDICTED: lysocardiolipin acyltransferase 1-like [Tribolium castaneum] -- -- -- -- -- K13513 LCLAT1, AGPAT8 lysocardiolipin and lysophospholipid acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13513 Q6UWP7 634 3.2e-64 Lysocardiolipin acyltransferase 1 OS=Homo sapiens GN=LCLAT1 PE=1 SV=1 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.28932 BF_2 15.74 8.94 357 189238225 XP_970862.2 257 3.7e-20 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414 TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.28933 BF_2 43.54 2.39 1050 189238225 XP_970862.2 508 8.5e-49 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- K11291 NASP nuclear autoantigenic sperm protein http://www.genome.jp/dbget-bin/www_bget?ko:K11291 Q02508 290 6.6e-25 Protein HGV2 OS=Halocynthia roretzi GN=HGV2 PE=2 SV=1 PF08631//PF01080//PF13181//PF13174//PF00515//PF02724//PF13414//PF13176 Meiosis protein SPO22/ZIP4 like//Presenilin//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//CDC45-like protein//TPR repeat//Tetratricopeptide repeat GO:0051321//GO:0006270 meiotic cell cycle//DNA replication initiation GO:0005515//GO:0004190 protein binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG4563 Cell cycle-regulated histone H1-binding protein Cluster-8309.28934 BF_2 124.46 3.35 1843 189238225 XP_970862.2 533 1.9e-51 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- K11291 NASP nuclear autoantigenic sperm protein http://www.genome.jp/dbget-bin/www_bget?ko:K11291 Q02508 290 1.2e-24 Protein HGV2 OS=Halocynthia roretzi GN=HGV2 PE=2 SV=1 PF00515//PF13181//PF13414//PF13174//PF13176//PF08702 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0030168 protein polymerization//signal transduction//platelet activation GO:0005515//GO:0030674//GO:0005102 protein binding//protein binding, bridging//receptor binding GO:0005577 fibrinogen complex KOG4563 Cell cycle-regulated histone H1-binding protein Cluster-8309.28937 BF_2 12.09 0.65 1064 546685593 ERL95080.1 545 4.4e-53 hypothetical protein D910_12350 [Dendroctonus ponderosae] 831293719 XM_012823057.1 42 2.12087e-10 PREDICTED: Clupea harengus cullin 2 (cul2), mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q5RCF3 413 3.7e-39 Cullin-2 OS=Pongo abelii GN=CUL2 PE=2 SV=1 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.28941 BF_2 131.16 1.56 3810 270012902 EFA09350.1 371 2.4e-32 hypothetical protein TcasGA2_TC001676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28942 BF_2 30.96 0.40 3487 642934319 XP_008198599.1 370 2.8e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28943 BF_2 40.10 0.69 2728 270007535 EFA03983.1 1973 2.9e-218 hypothetical protein TcasGA2_TC014132 [Tribolium castaneum] 823397955 XM_004395671.2 39 2.57732e-08 PREDICTED: Odobenus rosmarus divergens solute carrier family 6 (neurotransmitter transporter), member 6 (SLC6A6), mRNA K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 P48067 1203 2.3e-130 Sodium- and chloride-dependent glycine transporter 1 OS=Homo sapiens GN=SLC6A9 PE=2 SV=3 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.28944 BF_2 69.00 8.65 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28945 BF_2 29.68 1.09 1428 91089983 XP_974005.1 1138 1.0e-121 PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934014|ref|XP_008197604.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934016|ref|XP_008197605.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|270013684|gb|EFA10132.1| hypothetical protein TcasGA2_TC012312 [Tribolium castaneum] -- -- -- -- -- K15779 PGM2 phosphoglucomutase / phosphopentomutase http://www.genome.jp/dbget-bin/www_bget?ko:K15779 Q96G03 877 7.7e-93 Phosphoglucomutase-2 OS=Homo sapiens GN=PGM2 PE=1 SV=4 PF02880//PF02879//PF00408 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, C-terminal domain GO:0005975//GO:0071704 carbohydrate metabolic process//organic substance metabolic process GO:0046872//GO:0016868 metal ion binding//intramolecular transferase activity, phosphotransferases -- -- KOG1220 Phosphoglucomutase/phosphomannomutase Cluster-8309.28947 BF_2 765.55 5.36 6260 642918509 XP_008191502.1 7202 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 [Tribolium castaneum]>gi|270003219|gb|EEZ99666.1| hypothetical protein TcasGA2_TC002423 [Tribolium castaneum] 585685897 XM_006820162.1 110 2.0243e-47 PREDICTED: Saccoglossus kowalevskii brefeldin A-inhibited guanine nucleotide-exchange protein 1-like (LOC100366823), mRNA K18442 ARFGEF, BIG brefeldin A-inhibited guanine nucleotide-exchange protein http://www.genome.jp/dbget-bin/www_bget?ko:K18442 Q9Y6D5 5314 0.0e+00 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens GN=ARFGEF2 PE=1 SV=3 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity GO:0005622 intracellular KOG0929 Guanine nucleotide exchange factor Cluster-8309.28948 BF_2 354.00 14.80 1288 91078278 XP_971673.1 1321 5.5e-143 PREDICTED: probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial [Tribolium castaneum]>gi|270003914|gb|EFA00362.1| hypothetical protein TcasGA2_TC003204 [Tribolium castaneum] -- -- -- -- -- K00645 fabD http://www.genome.jp/dbget-bin/www_bget?ko:K00645 Q8T3L6 936 1.0e-99 Probable malonyl-CoA-acyl carrier protein transacylase, mitochondrial OS=Drosophila melanogaster GN=beg PE=2 SV=2 PF02617 ATP-dependent Clp protease adaptor protein ClpS GO:0030163//GO:0008152 protein catabolic process//metabolic process GO:0016740 transferase activity -- -- KOG2926 Malonyl-CoA:ACP transacylase Cluster-8309.2895 BF_2 4.00 1.42 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28950 BF_2 14.00 0.43 1656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28951 BF_2 24.83 0.33 3455 91075960 XP_969014.1 220 6.9e-15 PREDICTED: sarcalumenin [Tribolium castaneum]>gi|270014655|gb|EFA11103.1| hypothetical protein TcasGA2_TC004701 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28952 BF_2 859.15 5.85 6434 642928921 XP_008195617.1 9069 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] 642928920 XM_008197395.1 1391 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4872 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF01080//PF02985//PF00443//PF05395 Presenilin//HEAT repeat//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32 GO:0007165//GO:0016579 signal transduction//protein deubiquitination GO:0004190//GO:0004864//GO:0036459//GO:0005515 aspartic-type endopeptidase activity//protein phosphatase inhibitor activity//ubiquitinyl hydrolase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.28953 BF_2 162.94 1.09 6567 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.28954 BF_2 612.84 30.86 1118 91090252 XP_969934.1 425 3.8e-39 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 1.3e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.28956 BF_2 5.19 0.40 826 91087755 XP_974940.1 633 2.1e-63 PREDICTED: protein FAM50 homolog [Tribolium castaneum]>gi|270009391|gb|EFA05839.1| hypothetical protein TcasGA2_TC008623 [Tribolium castaneum] -- -- -- -- -- K13119 FAM50, XAP5 protein FAM50 http://www.genome.jp/dbget-bin/www_bget?ko:K13119 Q299F9 492 2.0e-48 Protein FAM50 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA11514 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2894 Uncharacterized conserved protein XAP-5 Cluster-8309.28959 BF_2 84.87 1.31 2997 91085405 XP_967263.1 739 4.0e-75 PREDICTED: serine/arginine-rich splicing factor 1A [Tribolium castaneum]>gi|270009156|gb|EFA05604.1| hypothetical protein TcasGA2_TC015810 [Tribolium castaneum] -- -- -- -- -- K12890 SFRS1_9 splicing factor, arginine/serine-rich 1/9 http://www.genome.jp/dbget-bin/www_bget?ko:K12890 Q5ZML3 597 4.8e-60 Serine/arginine-rich splicing factor 1 OS=Gallus gallus GN=SRSF1 PE=1 SV=3 PF00076//PF06929//PF08675//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Rotavirus VP3 protein//RNA binding domain//RNA recognition motif//RNA binding motif GO:0016032//GO:0006402//GO:0051252 viral process//mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0005525//GO:0000166//GO:0003676//GO:0004535//GO:0046872 RNA binding//GTP binding//nucleotide binding//nucleic acid binding//poly(A)-specific ribonuclease activity//metal ion binding GO:0005634//GO:0019013//GO:0005737 nucleus//viral nucleocapsid//cytoplasm KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily) Cluster-8309.28960 BF_2 975.13 17.65 2598 91085405 XP_967263.1 788 7.1e-81 PREDICTED: serine/arginine-rich splicing factor 1A [Tribolium castaneum]>gi|270009156|gb|EFA05604.1| hypothetical protein TcasGA2_TC015810 [Tribolium castaneum] -- -- -- -- -- K12890 SFRS1_9 splicing factor, arginine/serine-rich 1/9 http://www.genome.jp/dbget-bin/www_bget?ko:K12890 Q5ZML3 634 2.1e-64 Serine/arginine-rich splicing factor 1 OS=Gallus gallus GN=SRSF1 PE=1 SV=3 PF16367//PF06929//PF00076//PF08777 RNA recognition motif//Rotavirus VP3 protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0016032 viral process GO:0005525//GO:0000166//GO:0003723//GO:0003676 GTP binding//nucleotide binding//RNA binding//nucleic acid binding GO:0019013 viral nucleocapsid KOG0105 Alternative splicing factor ASF/SF2 (RRM superfamily) Cluster-8309.28961 BF_2 8.00 0.61 840 91084049 XP_967339.1 202 2.1e-13 PREDICTED: 40S ribosomal protein S8 [Tribolium castaneum]>gi|270008005|gb|EFA04453.1| hypothetical protein TcasGA2_TC014757 [Tribolium castaneum] 70909496 AM048935.1 55 9.84806e-18 Agriotes lineatus mRNA for ribosomal protein S8e (rpS8e gene) K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 Q8WQI5 183 1.3e-12 40S ribosomal protein S8 OS=Spodoptera frugiperda GN=RpS8 PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3283 40S ribosomal protein S8 Cluster-8309.28962 BF_2 173.32 4.02 2089 270013707 EFA10155.1 2383 6.4e-266 hypothetical protein TcasGA2_TC012343 [Tribolium castaneum] -- -- -- -- -- K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 1696 1.2e-187 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 PF10662//PF00071//PF04670//PF00910//PF07231//PF03193//PF00005//PF13202//PF02367//PF00036//PF00025//PF00004//PF01926//PF07475//PF08477//PF13405//PF00735//PF07728//PF01695//PF13499 Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//RNA helicase//Hs1pro-1 N-terminus//Protein of unknown function, DUF258//ABC transporter//EF hand//Threonylcarbamoyl adenosine biosynthesis protein TsaE//EF hand//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//HPr Serine kinase C-terminal domain//Ras of Complex, Roc, domain of DAPkinase//EF-hand domain//Septin//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//EF-hand domain pair GO:0006952//GO:0006109//GO:0000160//GO:0007264//GO:0002949//GO:0016310//GO:0006576 defense response//regulation of carbohydrate metabolic process//phosphorelay signal transduction system//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//phosphorylation//cellular biogenic amine metabolic process GO:0016887//GO:0003924//GO:0005524//GO:0000155//GO:0004672//GO:0003724//GO:0005525//GO:0005509//GO:0003723 ATPase activity//GTPase activity//ATP binding//phosphorelay sensor kinase activity//protein kinase activity//RNA helicase activity//GTP binding//calcium ion binding//RNA binding GO:0009365 protein histidine kinase complex KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.28965 BF_2 36.35 0.58 2890 642934418 XP_008197653.1 541 3.5e-52 PREDICTED: transformer-2 protein homolog beta isoform X4 [Tribolium castaneum] 642934411 XM_008199428.1 282 2.25732e-143 PREDICTED: Tribolium castaneum transformer-2 protein homolog beta (LOC656964), transcript variant X1, mRNA K12897 TRA2 transformer-2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12897 Q6PFR5 375 2.5e-34 Transformer-2 protein homolog alpha OS=Mus musculus GN=Tra2a PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.28966 BF_2 527.35 3.14 7314 642910921 XP_008193465.1 2693 2.5e-301 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha [Tribolium castaneum] -- -- -- -- -- K02649 PIK3R phosphoinositide-3-kinase, regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02649 Q63787 1128 3.1e-121 Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Rattus norvegicus GN=Pik3r1 PE=1 SV=1 PF07647//PF00536//PF00130//PF02198//PF02631//PF06815//PF14604//PF00620//PF00018 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Sterile alpha motif (SAM)/Pointed domain//RecX family//Reverse transcriptase connection domain//Variant SH3 domain//RhoGAP domain//SH3 domain GO:0035556//GO:0006278//GO:0007165//GO:0006282 intracellular signal transduction//RNA-dependent DNA replication//signal transduction//regulation of DNA repair GO:0043565//GO:0005515//GO:0003964 sequence-specific DNA binding//protein binding//RNA-directed DNA polymerase activity GO:0005634 nucleus KOG4637 Adaptor for phosphoinositide 3-kinase Cluster-8309.28967 BF_2 760.65 4.33 7632 642910921 XP_008193465.1 2830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase regulatory subunit alpha [Tribolium castaneum] -- -- -- -- -- K02649 PIK3R phosphoinositide-3-kinase, regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02649 Q63787 1128 3.2e-121 Phosphatidylinositol 3-kinase regulatory subunit alpha OS=Rattus norvegicus GN=Pik3r1 PE=1 SV=1 PF02198//PF02631//PF00620//PF07647//PF06815//PF00130//PF00536 Sterile alpha motif (SAM)/Pointed domain//RecX family//RhoGAP domain//SAM domain (Sterile alpha motif)//Reverse transcriptase connection domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif) GO:0035556//GO:0007165//GO:0006282//GO:0006278 intracellular signal transduction//signal transduction//regulation of DNA repair//RNA-dependent DNA replication GO:0043565//GO:0003964//GO:0005515 sequence-specific DNA binding//RNA-directed DNA polymerase activity//protein binding GO:0005634 nucleus KOG4637 Adaptor for phosphoinositide 3-kinase Cluster-8309.28968 BF_2 25.49 0.40 2958 478253953 ENN74245.1 1772 6.4e-195 hypothetical protein YQE_09217, partial [Dendroctonus ponderosae]>gi|546674841|gb|ERL86127.1| hypothetical protein D910_03541 [Dendroctonus ponderosae] 150013142 CP000743.1 37 3.61883e-07 Methanococcus aeolicus Nankai-3, complete genome K07767 KATNA1 katanin p60 ATPase-containing subunit A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07767 B4USW8 1439 1.1e-157 Katanin p60 ATPase-containing subunit A-like 1 OS=Otolemur garnettii GN=KATNAL1 PE=3 SV=1 PF02367//PF02562//PF00910//PF01080//PF06068//PF05496//PF07728//PF01695//PF07724//PF03286//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//RNA helicase//Presenilin//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//Pox virus Ag35 surface protein//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0002949//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0005524//GO:0003678//GO:0004190 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//ATP binding//DNA helicase activity//aspartic-type endopeptidase activity GO:0005657//GO:0009379//GO:0016021//GO:0019031 replication fork//Holliday junction helicase complex//integral component of membrane//viral envelope KOG0738 AAA+-type ATPase Cluster-8309.28969 BF_2 34.40 0.79 2109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.28970 BF_2 200.40 1.56 5662 189240823 XP_001811917.1 3289 0.0e+00 PREDICTED: ATP-dependent RNA helicase SUV3 homolog, mitochondrial [Tribolium castaneum]>gi|270013711|gb|EFA10159.1| hypothetical protein TcasGA2_TC012348 [Tribolium castaneum] 755880618 XM_005185469.2 352 0 PREDICTED: Musca domestica ATP-dependent RNA helicase SUV3 homolog, mitochondrial (LOC101900390), mRNA K17675 SUPV3L1, SUV3 ATP-dependent RNA helicase SUPV3L1/SUV3 http://www.genome.jp/dbget-bin/www_bget?ko:K17675 Q9VN03 2699 1.6e-303 ATP-dependent RNA helicase SUV3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG9791 PE=2 SV=3 PF12513//PF11965//PF00001 Mitochondrial degradasome RNA helicase subunit C terminal//Domain of unknown function (DUF3479)//7 transmembrane receptor (rhodopsin family) GO:0015994//GO:0007186 chlorophyll metabolic process//G-protein coupled receptor signaling pathway GO:0004930//GO:0004386//GO:0005524//GO:0003676//GO:0016817//GO:0016851 G-protein coupled receptor activity//helicase activity//ATP binding//nucleic acid binding//hydrolase activity, acting on acid anhydrides//magnesium chelatase activity GO:0010007//GO:0016021 magnesium chelatase complex//integral component of membrane KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily Cluster-8309.28972 BF_2 38.98 11.14 433 642930589 XP_008198247.1 314 1.1e-26 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum] -- -- -- -- -- K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q3ZBV8 204 2.6e-15 Threonine--tRNA ligase, cytoplasmic OS=Bos taurus GN=TARS PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.28973 BF_2 30.43 0.85 1786 642912959 XP_008201326.1 1150 5.2e-123 PREDICTED: programmed cell death 6-interacting protein [Tribolium castaneum]>gi|270001905|gb|EEZ98352.1| hypothetical protein TcasGA2_TC000807 [Tribolium castaneum] -- -- -- -- -- K12200 PDCD6IP, ALIX, RIM20 programmed cell death 6-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12200 Q9WU78 559 7.2e-56 Programmed cell death 6-interacting protein OS=Mus musculus GN=Pdcd6ip PE=1 SV=3 PF13949//PF06005//PF03462//PF14817//PF04111//PF17082//PF07926//PF10473//PF03938 ALIX V-shaped domain binding to HIV//Protein of unknown function (DUF904)//PCRF domain//HAUS augmin-like complex subunit 5//Autophagy protein Apg6//Spindle Pole Component 29//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Outer membrane protein (OmpH-like) GO:0006914//GO:0006606//GO:0006415//GO:0051225//GO:0006449//GO:0030474//GO:0000917//GO:0043093 autophagy//protein import into nucleus//translational termination//spindle assembly//regulation of translational termination//spindle pole body duplication//barrier septum assembly//FtsZ-dependent cytokinesis GO:0008134//GO:0045502//GO:0005200//GO:0051082//GO:0005515//GO:0016149//GO:0042803 transcription factor binding//dynein binding//structural constituent of cytoskeleton//unfolded protein binding//protein binding//translation release factor activity, codon specific//protein homodimerization activity GO:0005840//GO:0005823//GO:0018444//GO:0005737//GO:0070652//GO:0005856//GO:0030286//GO:0005667 ribosome//central plaque of spindle pole body//translation release factor complex//cytoplasm//HAUS complex//cytoskeleton//dynein complex//transcription factor complex KOG2220 Predicted signal transduction protein Cluster-8309.28975 BF_2 128.96 2.58 2375 546678596 ERL89178.1 1501 1.4e-163 hypothetical protein D910_06552 [Dendroctonus ponderosae] -- -- -- -- -- K14440 SMARCAL1, HARP SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14440 Q8MNV7 943 2.9e-100 Putative SMARCAL1-like protein OS=Caenorhabditis elegans GN=C16A3.1 PE=3 SV=1 PF00270//PF13949//PF01291//PF00176//PF04851 DEAD/DEAH box helicase//ALIX V-shaped domain binding to HIV//LIF / OSM family//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0007165//GO:0006955 signal transduction//immune response GO:0005515//GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0005125 protein binding//ATP binding//DNA binding//hydrolase activity//nucleic acid binding//cytokine activity GO:0005576 extracellular region KOG1000 Chromatin remodeling protein HARP/SMARCAL1, DEAD-box superfamily Cluster-8309.28977 BF_2 432.70 2.26 8286 642934565 XP_008197717.1 3886 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF01533//PF07714//PF06293//PF00069 Tospovirus nucleocapsid protein//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0016772//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//transferase activity, transferring phosphorus-containing groups//protein kinase activity GO:0016020//GO:0019013 membrane//viral nucleocapsid KOG0611 Predicted serine/threonine protein kinase Cluster-8309.28978 BF_2 629.57 4.62 5982 642923453 XP_008193751.1 4355 0.0e+00 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1597 1.1e-175 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF00400//PF02460 WD domain, G-beta repeat//Patched family GO:0007165 signal transduction GO:0005515//GO:0008158 protein binding//hedgehog receptor activity GO:0016020 membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.28980 BF_2 73.32 0.40 7876 189241335 XP_001809545.1 1176 2.2e-125 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 154 8.8526e-72 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 794 1.8e-82 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF00876//PF06662//PF01292 Innexin//D-glucuronyl C5-epimerase C-terminus//Prokaryotic cytochrome b561 GO:0006118//GO:0006024 obsolete electron transport//glycosaminoglycan biosynthetic process GO:0016857//GO:0009055 racemase and epimerase activity, acting on carbohydrates and derivatives//electron carrier activity GO:0005921//GO:0016021 gap junction//integral component of membrane -- -- Cluster-8309.28982 BF_2 8.71 0.40 1193 91087501 XP_968536.1 559 1.2e-54 PREDICTED: DNA replication complex GINS protein PSF3 [Tribolium castaneum]>gi|270010665|gb|EFA07113.1| hypothetical protein TcasGA2_TC010104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDV0 242 2.8e-19 DNA replication complex GINS protein PSF3 OS=Pongo abelii GN=GINS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.28987 BF_2 77.64 1.14 3138 270012872 EFA09320.1 264 5.0e-20 hypothetical protein TcasGA2_TC001646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10394 Histone acetyl transferase HAT1 N-terminus GO:0016568//GO:0042967 chromatin modification//acyl-carrier-protein biosynthetic process GO:0004402 histone acetyltransferase activity GO:0000123 histone acetyltransferase complex -- -- Cluster-8309.28989 BF_2 68.28 0.61 4958 91093137 XP_969665.1 1842 8.2e-203 PREDICTED: breast cancer anti-estrogen resistance protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16832 NEDD9, HEF1, CASL enhancer of filamentation 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16832 Q61140 506 2.8e-49 Breast cancer anti-estrogen resistance protein 1 OS=Mus musculus GN=Bcar1 PE=1 SV=2 PF09726//PF01282 Transmembrane protein//Ribosomal protein S24e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular -- -- Cluster-8309.28994 BF_2 3478.57 104.25 1683 478260112 ENN79897.1 1512 5.2e-165 hypothetical protein YQE_03716, partial [Dendroctonus ponderosae]>gi|546679495|gb|ERL89954.1| hypothetical protein D910_07313 [Dendroctonus ponderosae] -- -- -- -- -- K00415 QCR2, UQCRC2 ubiquinol-cytochrome c reductase core subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K00415 Q9DB77 705 8.0e-73 Cytochrome b-c1 complex subunit 2, mitochondrial OS=Mus musculus GN=Uqcrc2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2583 Ubiquinol cytochrome c reductase, subunit QCR2 Cluster-8309.28996 BF_2 19.49 0.59 1670 642914748 XP_008190336.1 1749 1.7e-192 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 474 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04947 KCNT2 potassium channel subfamily T member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04947 Q6UVM4 500 4.7e-49 Potassium channel subfamily T member 2 OS=Rattus norvegicus GN=Kcnt2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3193 K+ channel subunit Cluster-8309.28998 BF_2 948.79 43.67 1196 91084843 XP_966905.1 737 2.7e-75 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 531 8.5e-53 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF01073//PF01118//PF01370//PF03435 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0016491//GO:0051287//GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.28999 BF_2 12.15 0.37 1653 91084843 XP_966905.1 274 1.8e-21 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 153 8.0e-09 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF07962 Male sterility protein//Replication Fork Protection Component Swi3 GO:0048478//GO:0006974//GO:0007049 replication fork protection//cellular response to DNA damage stimulus//cell cycle GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity GO:0005634 nucleus -- -- Cluster-8309.29000 BF_2 15.42 0.45 1727 642914803 XP_008190360.1 247 2.6e-18 PREDICTED: poly(rC)-binding protein 3 isoform X2 [Tribolium castaneum] 642914804 XM_964518.3 182 5.20438e-88 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29002 BF_2 23.84 1.20 1121 91081971 XP_967978.1 860 1.4e-89 PREDICTED: plexin domain-containing protein 2 [Tribolium castaneum]>gi|270007319|gb|EFA03767.1| hypothetical protein TcasGA2_TC013878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DC11 499 4.1e-49 Plexin domain-containing protein 2 OS=Mus musculus GN=Plxdc2 PE=1 SV=1 PF01437 Plexin repeat -- -- -- -- GO:0016020 membrane KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-8309.29003 BF_2 82.03 1.04 3597 642922441 XP_008193170.1 2357 1.1e-262 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922836 XM_008195125.1 329 2.10162e-169 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X1, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1929 2.0e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF00180//PF02781//PF00479 Isocitrate/isopropylmalate dehydrogenase//Glucose-6-phosphate dehydrogenase, C-terminal domain//Glucose-6-phosphate dehydrogenase, NAD binding domain GO:0006006//GO:0006749//GO:0006098//GO:0055114 glucose metabolic process//glutathione metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0016616//GO:0004345 NADP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.29004 BF_2 80.22 0.62 5734 642927663 XP_008195354.1 1331 1.7e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.4e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.29008 BF_2 21.00 0.46 2179 546682094 ERL92080.1 359 3.3e-31 hypothetical protein D910_09402, partial [Dendroctonus ponderosae] -- -- -- -- -- K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 P48809 324 1.6e-28 Heterogeneous nuclear ribonucleoprotein 27C OS=Drosophila melanogaster GN=Hrb27C PE=1 SV=2 PF00076//PF16367//PF15150 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Phorbol-12-myristate-13-acetate-induced GO:0006919//GO:0006915//GO:0006974//GO:0001836 activation of cysteine-type endopeptidase activity involved in apoptotic process//apoptotic process//cellular response to DNA damage stimulus//release of cytochrome c from mitochondria GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.29012 BF_2 10.00 0.71 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29014 BF_2 24.13 0.52 2213 478253168 ENN73539.1 316 3.3e-26 hypothetical protein YQE_09790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q867Z4 288 2.4e-24 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01155//PF00096//PF13465//PF01428//PF16622//PF02892//PF01363 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain//AN1-like Zinc finger//zinc-finger C2H2-type//BED zinc finger//FYVE zinc finger GO:0006464 cellular protein modification process GO:0008270//GO:0003677//GO:0016151//GO:0046872 zinc ion binding//DNA binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.29015 BF_2 11.00 0.93 782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29018 BF_2 240.00 24.50 697 642927242 XP_008195193.1 154 6.3e-08 PREDICTED: uncharacterized protein LOC103313523 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29020 BF_2 93.13 1.02 4110 642912971 XP_008201333.1 1018 2.4e-107 PREDICTED: claspin homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29021 BF_2 86.87 1.01 3881 642912965 XP_008201330.1 1050 4.4e-111 PREDICTED: claspin homolog isoform X1 [Tribolium castaneum]>gi|642912967|ref|XP_008201331.1| PREDICTED: claspin homolog isoform X1 [Tribolium castaneum]>gi|642912969|ref|XP_008201332.1| PREDICTED: claspin homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29023 BF_2 546.35 6.12 4020 189236877 XP_974696.2 4794 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1864 7.7e-207 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF05236//PF03810//PF00822 Transcription initiation factor TFIID component TAF4 family//Importin-beta N-terminal domain//PMP-22/EMP/MP20/Claudin family GO:0006352//GO:0006886 DNA-templated transcription, initiation//intracellular protein transport GO:0008536 Ran GTPase binding GO:0016021//GO:0005669 integral component of membrane//transcription factor TFIID complex KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.29025 BF_2 756.45 19.40 1918 642919394 XP_008191854.1 1370 1.7e-148 PREDICTED: apoptosis inhibitor 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35841 852 8.2e-90 Apoptosis inhibitor 5 OS=Mus musculus GN=Api5 PE=1 SV=2 PF01031//PF00714 Dynamin central region//Interferon gamma GO:0007165//GO:0006955 signal transduction//immune response GO:0005133//GO:0005525 interferon-gamma receptor binding//GTP binding GO:0005576 extracellular region KOG2213 Apoptosis inhibitor 5/fibroblast growth factor 2-interacting factor 2, and related proteins Cluster-8309.29032 BF_2 7.00 18.11 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29033 BF_2 322.13 8.02 1968 751230832 XP_011168942.1 177 3.8e-10 PREDICTED: vascular endothelial growth factor A-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.29034 BF_2 5121.96 87.85 2726 91094851 XP_972051.1 2113 1.7e-234 PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating [Tribolium castaneum]>gi|270006577|gb|EFA03025.1| hypothetical protein TcasGA2_TC010448 [Tribolium castaneum] 808352053 KR024162.1 90 1.14842e-36 Drosophila melanogaster strain ZK398 ph-p-RA (ph-p) gene, partial sequence; CG3835 (CG3835) and Pgd (Pgd) genes, complete cds, alternatively spliced; bcn92-RA (bcn92) gene, complete cds; wapl (wapl) and Cyp4d1 (Cyp4d1) genes, complete cds, alternatively spliced; and CG3630-RD (CG3630) gene, partial sequence K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P41570 1734 6.2e-192 6-phosphogluconate dehydrogenase, decarboxylating OS=Ceratitis capitata GN=Pgd PE=2 SV=1 PF14833//PF03446//PF00393 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase//6-phosphogluconate dehydrogenase, C-terminal domain GO:0019521//GO:0006098//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0004616//GO:0051287 NADP binding//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-8309.29035 BF_2 173.45 3.28 2496 91083363 XP_975142.1 1914 1.9e-211 PREDICTED: diacylglycerol O-acyltransferase 1 [Tribolium castaneum]>gi|270007773|gb|EFA04221.1| hypothetical protein TcasGA2_TC014471 [Tribolium castaneum] -- -- -- -- -- K11155 DGAT1 diacylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11155 Q9Z2A7 996 2.1e-106 Diacylglycerol O-acyltransferase 1 OS=Mus musculus GN=Dgat1 PE=1 SV=1 -- -- GO:0042967 acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase Cluster-8309.29036 BF_2 32.00 8.46 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29038 BF_2 33.49 0.49 3143 829834995 XP_012634098.1 661 4.6e-66 PREDICTED: zinc finger MYM-type protein 2 isoform X2 [Microcebus murinus] -- -- -- -- -- -- -- -- -- Q96DM1 321 5.0e-28 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01609//PF08188 Transposase DDE domain//Spermatozal protamine family GO:0035092//GO:0006313 sperm chromatin condensation//transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity GO:0000228 nuclear chromosome -- -- Cluster-8309.29040 BF_2 1283.78 18.53 3186 91088135 XP_970927.1 2676 1.0e-299 PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum]>gi|642931216|ref|XP_008196487.1| PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum] -- -- -- -- -- K14015 NPLOC4, NPL4 nuclear protein localization protein 4 homolog http://www.genome.jp/dbget-bin/www_bget?ko:K14015 Q9VBP9 1976 6.3e-220 Nuclear protein localization protein 4 homolog OS=Drosophila melanogaster GN=Npl4 PE=1 SV=3 PF02565//PF15957//PF00641 Recombination protein O C terminal//Commissureless//Zn-finger in Ran binding protein and others GO:0007411//GO:0006310//GO:0006281 axon guidance//DNA recombination//DNA repair GO:0008270 zinc ion binding -- -- KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4) Cluster-8309.29041 BF_2 23.00 1.87 803 57868645 AAW57431.1 376 1.3e-33 10G08 [Ips pini] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29046 BF_2 314.68 3.28 4299 642912121 XP_008200815.1 1303 2.3e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R1R3 469 4.7e-45 StAR-related lipid transfer protein 7, mitochondrial OS=Mus musculus GN=Stard7 PE=2 SV=2 PF01593//PF12831//PF07992//PF09452//PF01494//PF08264//PF01852//PF01134//PF01266//PF00965 Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//ESCRT-I subunit Mvb12//FAD binding domain//Anticodon-binding domain of tRNA//START domain//Glucose inhibited division protein A//FAD dependent oxidoreductase//Tissue inhibitor of metalloproteinase GO:0006418//GO:0055114//GO:0008033//GO:0032509 tRNA aminoacylation for protein translation//oxidation-reduction process//tRNA processing//endosome transport via multivesicular body sorting pathway GO:0000166//GO:0050660//GO:0043130//GO:0008289//GO:0008191//GO:0071949//GO:0016491 nucleotide binding//flavin adenine dinucleotide binding//ubiquitin binding//lipid binding//metalloendopeptidase inhibitor activity//FAD binding//oxidoreductase activity GO:0000813 ESCRT I complex KOG0685 Flavin-containing amine oxidase Cluster-8309.29048 BF_2 100.46 1.14 3981 642928280 XP_008195517.1 1862 3.2e-205 PREDICTED: uncharacterized protein LOC658443 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12737 SDCCAG10 peptidyl-prolyl cis-trans isomerase SDCCAG10 http://www.genome.jp/dbget-bin/www_bget?ko:K12737 Q6UX04 626 2.7e-63 Peptidyl-prolyl cis-trans isomerase CWC27 homolog OS=Homo sapiens GN=CWC27 PE=1 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0885 Peptidyl-prolyl cis-trans isomerase Cluster-8309.29049 BF_2 589.75 12.58 2249 91079304 XP_966317.1 1435 5.8e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 4.4e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.29052 BF_2 98.86 6.40 933 546676446 ERL87451.1 215 7.1e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29054 BF_2 4.68 6.69 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29055 BF_2 272.01 3.81 3271 642932518 XP_008197147.1 3114 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X3 [Tribolium castaneum] 642932517 XM_008198925.1 692 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 2566 2.5e-288 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 PF07714//PF00069//PF17082 Protein tyrosine kinase//Protein kinase domain//Spindle Pole Component 29 GO:0030474//GO:0006468 spindle pole body duplication//protein phosphorylation GO:0004672//GO:0005524//GO:0005200 protein kinase activity//ATP binding//structural constituent of cytoskeleton GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG0614 cGMP-dependent protein kinase Cluster-8309.29057 BF_2 851.76 13.02 3023 478252036 ENN72467.1 917 9.1e-96 hypothetical protein YQE_10809, partial [Dendroctonus ponderosae] 586460488 XM_006860838.1 137 9.51545e-63 PREDICTED: Chrysochloris asiatica NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (NDUFS8), mRNA K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 P42028 772 2.4e-80 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Bos taurus GN=NDUFS8 PE=1 SV=1 PF08782//PF05187//PF03194 c-SKI Smad4 binding domain//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S//LUC7 N_terminus GO:0006376//GO:0055114 mRNA splice site selection//oxidation-reduction process GO:0004174//GO:0046332//GO:0003729 electron-transferring-flavoprotein dehydrogenase activity//SMAD binding//mRNA binding GO:0005685 U1 snRNP KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit Cluster-8309.29058 BF_2 3.05 1.19 393 546682595 ERL92514.1 286 1.7e-23 hypothetical protein D910_09827 [Dendroctonus ponderosae] 318037409 NM_001201142.1 52 2.04713e-16 Ictalurus punctatus serine/threonine-protein phosphatase 2a regulatory subunit b' (ptpa), mRNA >gnl|BL_ORD_ID|9527029 Ictalurus punctatus clone CBPN47522 serine/threonine-protein phosphatase 2a regulatory subunit b' (PTPA) mRNA, complete cds K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 223 1.4e-17 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF03095 Phosphotyrosyl phosphate activator (PTPA) protein -- -- GO:0019211 phosphatase activator activity -- -- KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.29059 BF_2 303.45 2.36 5670 642922255 XP_008193081.1 3697 0.0e+00 PREDICTED: sodium bicarbonate cotransporter 3 isoform X2 [Tribolium castaneum] 642922254 XM_008194859.1 405 0 PREDICTED: Tribolium castaneum sodium bicarbonate cotransporter 3 (LOC661759), transcript variant X4, mRNA -- -- -- -- Q32LP4 2294 1.5e-256 Sodium-driven chloride bicarbonate exchanger OS=Bos taurus GN=SLC4A10 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.29063 BF_2 486.06 6.31 3511 91088615 XP_974002.1 834 4.5e-86 PREDICTED: sepiapterin reductase [Tribolium castaneum]>gi|270012265|gb|EFA08713.1| hypothetical protein TcasGA2_TC006384 [Tribolium castaneum] -- -- -- -- -- K00072 SPR sepiapterin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00072 P35270 313 4.8e-27 Sepiapterin reductase OS=Homo sapiens GN=SPR PE=1 SV=1 PF00769//PF05130//PF12242//PF00106 Ezrin/radixin/moesin family//FlgN protein//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase GO:0055114//GO:0008152//GO:0044780 oxidation-reduction process//metabolic process//bacterial-type flagellum assembly GO:0016491//GO:0008092 oxidoreductase activity//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG1204 Predicted dehydrogenase Cluster-8309.29065 BF_2 62.00 0.65 4267 478253167 ENN73538.1 399 1.5e-35 hypothetical protein YQE_09789, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y2L8 139 8.7e-07 Zinc finger protein with KRAB and SCAN domains 5 OS=Homo sapiens GN=ZKSCAN5 PE=1 SV=1 PF13465//PF00096//PF05191//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate kinase, active site lid//C2H2-type zinc finger GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.29066 BF_2 20.00 4.33 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29069 BF_2 22.99 0.45 2405 815806339 XP_012223941.1 320 1.2e-26 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105673125 [Linepithema humile] 642916990 XM_967678.2 157 5.75626e-74 PREDICTED: Tribolium castaneum protein translation factor SUI1 homolog (LOC661525), mRNA K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 P42678 292 8.9e-25 Protein translation factor SUI1 homolog OS=Anopheles gambiae GN=AGAP006459 PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.29070 BF_2 64.15 1.87 1720 642921367 XP_008192837.1 1077 1.5e-114 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K12375 ARSI_J arylsulfatase I/J http://www.genome.jp/dbget-bin/www_bget?ko:K12375 Q5FYB1 296 2.2e-25 Arylsulfatase I OS=Homo sapiens GN=ARSI PE=1 SV=1 PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- KOG3867 Sulfatase Cluster-8309.29072 BF_2 5.00 0.43 770 642922682 XP_008193278.1 183 3.0e-11 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IIH7 124 8.6e-06 Suppressor of tumorigenicity 14 protein homolog OS=Bos taurus GN=ST14 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.29074 BF_2 31.00 1.92 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29075 BF_2 341.83 13.25 1366 642921592 XP_008192437.1 1154 1.4e-123 PREDICTED: peptidyl-prolyl cis-trans isomerase D [Tribolium castaneum]>gi|270005014|gb|EFA01462.1| hypothetical protein TcasGA2_TC007008 [Tribolium castaneum] -- -- -- -- -- K05864 PPID, CYPD peptidyl-prolyl isomerase D http://www.genome.jp/dbget-bin/www_bget?ko:K05864 Q9CR16 774 6.5e-81 Peptidyl-prolyl cis-trans isomerase D OS=Mus musculus GN=Ppid PE=1 SV=3 PF13181//PF00515//PF13371//PF00160//PF13174//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Tetratricopeptide repeat//TPR repeat GO:0044267//GO:0000413//GO:0006457 cellular protein metabolic process//protein peptidyl-prolyl isomerization//protein folding GO:0005515//GO:0016853//GO:0003755 protein binding//isomerase activity//peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.29078 BF_2 11.73 1.43 630 642920229 XP_008192257.1 441 3.0e-41 PREDICTED: 60S ribosomal protein L10a isoform X1 [Tribolium castaneum] 315115352 HQ424705.1 140 4.0834e-65 Euphydryas aurinia ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 404 2.4e-38 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00468 Ribosomal protein L34 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1570 60S ribosomal protein L10A Cluster-8309.29083 BF_2 1635.00 18.67 3951 768431235 XP_011556884.1 5698 0.0e+00 PREDICTED: DNA-directed RNA polymerase II subunit RPB2 [Plutella xylostella] 324120671 AB597621.1 1401 0 Lucidina biplagiata RPB2 mRNA for RNA polymerase II second largest subunit, complete cds, isolate: E-19 K03010 RPB2, POLR2B DNA-directed RNA polymerase II subunit RPB2 http://www.genome.jp/dbget-bin/www_bget?ko:K03010 P30876 5320 0.0e+00 DNA-directed RNA polymerase II subunit RPB2 OS=Homo sapiens GN=POLR2B PE=1 SV=1 PF04563//PF00562//PF04560//PF04566//PF04565//PF04561//PF04567 RNA polymerase beta subunit//RNA polymerase Rpb2, domain 6//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 4//RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 2//RNA polymerase Rpb2, domain 5 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG0214 RNA polymerase II, second largest subunit Cluster-8309.29084 BF_2 29.77 0.56 2512 189238013 XP_001813375.1 1533 2.8e-167 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 52 1.40766e-15 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1144 1.5e-123 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF03193//PF07728//PF00005//PF06414//PF13304//PF00664//PF00437 Protein of unknown function, DUF258//AAA domain (dynein-related subfamily)//ABC transporter//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0006200//GO:0006810//GO:0055085 obsolete ATP catabolic process//transport//transmembrane transport GO:0042626//GO:0016887//GO:0016301//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.29085 BF_2 383.90 7.81 2343 91094449 XP_966613.1 1311 1.5e-141 PREDICTED: 8-oxo-dGDP phosphatase NUDT18 [Tribolium castaneum]>gi|270000740|gb|EEZ97187.1| hypothetical protein TcasGA2_TC004374 [Tribolium castaneum] -- -- -- -- -- K17817 NUDT18, MTH3 8-oxo-dGDP phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17817 Q6ZVK8 397 5.8e-37 8-oxo-dGDP phosphatase NUDT18 OS=Homo sapiens GN=NUDT18 PE=1 SV=3 PF00293//PF13869 NUDIX domain//Nucleotide hydrolase GO:0006378 mRNA polyadenylation GO:0003729//GO:0016787 mRNA binding//hydrolase activity GO:0005849 mRNA cleavage factor complex KOG0648 Predicted NUDIX hydrolase FGF-2 and related proteins Cluster-8309.29087 BF_2 218.00 15.95 859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29088 BF_2 542.39 16.44 1667 642923490 XP_008193532.1 1769 8.1e-195 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 75 1.51936e-28 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 1234 3.6e-134 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00159//PF00852 Pancreatic hormone peptide//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486//GO:0007165 protein glycosylation//signal transduction GO:0008417//GO:0005179 fucosyltransferase activity//hormone activity GO:0005576//GO:0016020 extracellular region//membrane KOG2619 Fucosyltransferase Cluster-8309.29089 BF_2 117.00 12.46 680 -- -- -- -- -- 642923232 XM_008195446.1 143 9.51301e-67 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29092 BF_2 1358.00 42.15 1635 91083571 XP_967903.1 1714 1.9e-188 PREDICTED: bystin [Tribolium castaneum]>gi|270006847|gb|EFA03295.1| hypothetical protein TcasGA2_TC013235 [Tribolium castaneum] 749731347 XM_011156599.1 191 4.8867e-93 PREDICTED: Harpegnathos saltator bystin (LOC105192443), mRNA K14797 ENP1, BYSL essential nuclear protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14797 Q5E9N0 1252 2.9e-136 Bystin OS=Bos taurus GN=BYSL PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3871 Cell adhesion complex protein bystin Cluster-8309.29093 BF_2 173.28 2.02 3884 546682290 ERL92248.1 263 8.0e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 3.0e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.29094 BF_2 159.57 1.87 3866 478255594 ENN75808.1 263 8.0e-20 hypothetical protein YQE_07644, partial [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 3.0e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.29095 BF_2 15.83 0.31 2451 749749994 XP_011137233.1 350 4.1e-30 PREDICTED: ninjurin-1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P70617 178 1.5e-11 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF01080//PF06424//PF02724 Ninjurin//Presenilin//PRP1 splicing factor, N-terminal//CDC45-like protein GO:0007155//GO:0000398//GO:0006270//GO:0042246 cell adhesion//mRNA splicing, via spliceosome//DNA replication initiation//tissue regeneration GO:0004190 aspartic-type endopeptidase activity GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.29097 BF_2 1481.71 36.75 1974 270009512 EFA05960.1 1428 3.3e-155 hypothetical protein TcasGA2_TC008778 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P20060 1177 1.7e-127 Beta-hexosaminidase subunit beta OS=Mus musculus GN=Hexb PE=2 SV=2 PF09328//PF08013//PF00728//PF08085 Domain of unknown function (DUF1984)//Tagatose 6 phosphate kinase//Glycosyl hydrolase family 20, catalytic domain//Entericidin EcnA/B family GO:0010038//GO:0009636//GO:0019402//GO:0005975//GO:0046938 response to metal ion//response to toxic substance//galactitol metabolic process//carbohydrate metabolic process//phytochelatin biosynthetic process GO:0004553//GO:0016756//GO:0046872 hydrolase activity, hydrolyzing O-glycosyl compounds//glutathione gamma-glutamylcysteinyltransferase activity//metal ion binding GO:0016020 membrane KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.291 BF_2 5.00 0.39 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29101 BF_2 97.00 4.60 1169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29106 BF_2 24.39 0.31 3603 642939073 XP_008200211.1 1985 1.6e-219 PREDICTED: DEAD-box ATP-dependent RNA helicase 20-like isoform X2 [Tribolium castaneum] 158300605 XM_320481.4 215 4.96062e-106 Anopheles gambiae str. PEST AGAP012045-PA (AgaP_AGAP012045) mRNA, complete cds K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1374 4.6e-150 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF04851//PF03328//PF00816//PF00270 Type III restriction enzyme, res subunit//HpcH/HpaI aldolase/citrate lyase family//H-NS histone family//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0016787//GO:0003677//GO:0003676//GO:0005524//GO:0003824 hydrolase activity//DNA binding//nucleic acid binding//ATP binding//catalytic activity GO:0005622 intracellular KOG0331 ATP-dependent RNA helicase Cluster-8309.29107 BF_2 5.00 0.38 841 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02148 Zn-finger in ubiquitin-hydrolases and other protein -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.29109 BF_2 1.00 0.59 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29112 BF_2 17.11 0.87 1106 478252538 ENN72954.1 1071 4.6e-114 hypothetical protein YQE_10425, partial [Dendroctonus ponderosae] 642913068 XM_008203154.1 168 1.9992e-80 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 670 6.0e-69 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.29120 BF_2 364.00 16.41 1215 270006529 EFA02977.1 1107 3.4e-118 hypothetical protein TcasGA2_TC030780 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64676 327 3.9e-29 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Mus musculus GN=Ugt8 PE=2 SV=2 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.29124 BF_2 5.44 19.16 264 189234439 XP_966311.2 450 1.1e-42 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [Tribolium castaneum] 642913316 XM_961218.3 120 2.07713e-54 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(q) subunit alpha (LOC654901), transcript variant X2, mRNA K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P91950 443 3.0e-43 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homarus americanus PE=2 SV=1 PF00503//PF00025 G-protein alpha subunit//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0031683//GO:0004871//GO:0019001//GO:0003924 GTP binding//G-protein beta/gamma-subunit complex binding//signal transducer activity//guanyl nucleotide binding//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.29125 BF_2 3541.27 33.55 4703 189237690 XP_969477.2 3405 0.0e+00 PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|642924144|ref|XP_008194025.1| PREDICTED: signal transducer and activator of transcription 5B isoform X1 [Tribolium castaneum]>gi|270008133|gb|EFA04581.1| signal-transducer and activator of transcription protein [Tribolium castaneum] 642924143 XM_008195803.1 434 0 PREDICTED: Tribolium castaneum signal-transducer and activator of transcription protein (LOC657965), transcript variant X2, mRNA K11224 STAT5B signal transducer and activator of transcription 5B http://www.genome.jp/dbget-bin/www_bget?ko:K11224 Q9TUZ0 1741 1.7e-192 Signal transducer and activator of transcription 5B OS=Sus scrofa GN=STAT5B PE=2 SV=1 PF01017//PF02865//PF02864 STAT protein, all-alpha domain//STAT protein, protein interaction domain//STAT protein, DNA binding domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0004871//GO:0005509//GO:0003700 signal transducer activity//calcium ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.29126 BF_2 2.00 30.29 223 478251023 ENN71504.1 389 1.1e-35 hypothetical protein YQE_11797, partial [Dendroctonus ponderosae] 725566855 XM_010338088.1 145 2.17569e-68 PREDICTED: Saimiri boliviensis boliviensis tubulin beta chain-like (LOC101051381), mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P08841 380 5.1e-36 Tubulin beta-3 chain OS=Drosophila melanogaster GN=betaTub60D PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1375 Beta tubulin Cluster-8309.29127 BF_2 168.92 4.74 1778 189237989 XP_001812744.1 753 5.6e-77 PREDICTED: ceramide-1-phosphate transfer protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DBQ8 353 5.5e-32 Ceramide-1-phosphate transfer protein OS=Danio rerio GN=cptp PE=2 SV=1 PF13603//PF08718 Leucyl-tRNA synthetase, Domain 2//Glycolipid transfer protein (GLTP) GO:0006418//GO:0046836 tRNA aminoacylation for protein translation//glycolipid transport GO:0051861//GO:0017089//GO:0002161 glycolipid binding//glycolipid transporter activity//aminoacyl-tRNA editing activity GO:0005737 cytoplasm KOG4189 Uncharacterized conserved protein Cluster-8309.29129 BF_2 53.29 3.29 964 546684237 ERL93942.1 434 3.0e-40 hypothetical protein D910_11228 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29130 BF_2 27.74 1.79 937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29131 BF_2 73.91 1.01 3353 478254650 ENN74891.1 1311 2.1e-141 hypothetical protein YQE_08470, partial [Dendroctonus ponderosae] 195480065 XM_002101088.1 119 1.07173e-52 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.29133 BF_2 27.15 0.70 1920 270007709 EFA04157.1 1872 1.1e-206 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 994 2.8e-106 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF13304//PF01926//PF00664 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.29135 BF_2 39.00 0.61 2959 91089793 XP_968467.1 2220 7.2e-247 PREDICTED: hexosaminidase D isoform X1 [Tribolium castaneum]>gi|270013626|gb|EFA10074.1| hypothetical protein TcasGA2_TC012248 [Tribolium castaneum] 642933757 XM_008193321.1 239 1.85155e-119 PREDICTED: Tribolium castaneum hexosaminidase D (LOC656874), transcript variant X2, mRNA K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q3U4H6 819 8.5e-86 Hexosaminidase D OS=Mus musculus GN=Hexdc PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0006355//GO:0005975 regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0004553//GO:0043169//GO:0043565//GO:0003700 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.29137 BF_2 352.60 10.74 1661 642920923 XP_008192617.1 1079 8.2e-115 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q5ZK84 582 1.4e-58 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.29138 BF_2 325.00 30.70 730 91093647 XP_967704.1 765 9.3e-79 PREDICTED: protein mago nashi [Tribolium castaneum]>gi|270015823|gb|EFA12271.1| mago nashi [Tribolium castaneum] -- -- -- -- -- K12877 MAGOH protein mago nashi http://www.genome.jp/dbget-bin/www_bget?ko:K12877 P49028 716 1.8e-74 Protein mago nashi OS=Drosophila melanogaster GN=mago PE=1 SV=1 PF02792 Mago nashi protein -- -- -- -- GO:0005634 nucleus KOG3392 Exon-exon junction complex, Magoh component Cluster-8309.29139 BF_2 16.32 0.72 1235 332372492 AEE61388.1 440 7.6e-41 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PHE8 302 3.2e-26 Coiled-coil domain-containing protein 124 OS=Danio rerio GN=ccdc124 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3223 Uncharacterized conserved protein Cluster-8309.29140 BF_2 827.74 5.81 6250 270005549 EFA01997.1 4656 0.0e+00 hypothetical protein TcasGA2_TC007618 [Tribolium castaneum] 642919307 XM_008193597.1 101 2.0354e-42 PREDICTED: Tribolium castaneum signal-induced proliferation-associated 1-like protein 2 (LOC660473), transcript variant X2, mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q80TE4 1803 1.4e-199 Signal-induced proliferation-associated 1-like protein 2 OS=Mus musculus GN=Sipa1l2 PE=1 SV=3 PF06005//PF00595//PF04799//PF06221//PF02145 Protein of unknown function (DUF904)//PDZ domain (Also known as DHR or GLGF)//fzo-like conserved region//Putative zinc finger motif, C2HC5-type//Rap/ran-GAP GO:0051056//GO:0006355//GO:0008053//GO:0000917//GO:0043093 regulation of small GTPase mediated signal transduction//regulation of transcription, DNA-templated//mitochondrial fusion//barrier septum assembly//FtsZ-dependent cytokinesis GO:0005096//GO:0003924//GO:0005515//GO:0008270 GTPase activator activity//GTPase activity//protein binding//zinc ion binding GO:0005634//GO:0016021//GO:0005741//GO:0005737 nucleus//integral component of membrane//mitochondrial outer membrane//cytoplasm KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.29142 BF_2 8.11 0.31 1365 642911443 XP_008199425.1 1196 1.8e-128 PREDICTED: hydroxymethylglutaryl-CoA lyase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01640 E4.1.3.4, HMGCL, hmgL hydroxymethylglutaryl-CoA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01640 D4A5C3 941 2.8e-100 3-hydroxymethyl-3-methylglutaryl-CoA lyase, cytoplasmic OS=Rattus norvegicus GN=Hmgcll1 PE=1 SV=1 PF00682 HMGL-like -- -- GO:0003824 catalytic activity -- -- KOG2368 Hydroxymethylglutaryl-CoA lyase Cluster-8309.29143 BF_2 118.70 1.04 5051 546681087 ERL91243.1 3068 0.0e+00 hypothetical protein D910_08578 [Dendroctonus ponderosae] -- -- -- -- -- K16685 WWC1 protein KIBRA http://www.genome.jp/dbget-bin/www_bget?ko:K16685 B4K6I9 1037 7.6e-111 Protein kibra OS=Drosophila mojavensis GN=Kibra PE=3 SV=1 PF05180//PF00168//PF00397//PF01253 DNL zinc finger//C2 domain//WW domain//Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003743//GO:0008270 protein binding//translation initiation factor activity//zinc ion binding GO:0005840 ribosome -- -- Cluster-8309.29144 BF_2 100.16 0.72 6076 642925611 XP_008194640.1 2652 1.2e-296 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 2.6e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29145 BF_2 45.23 0.42 4747 642926029 XP_969555.3 1919 9.3e-212 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 3.46211e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 2.9e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29147 BF_2 6.88 0.59 776 478250454 ENN70949.1 316 1.1e-26 hypothetical protein YQE_12350, partial [Dendroctonus ponderosae]>gi|546677323|gb|ERL88180.1| hypothetical protein D910_05568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29150 BF_2 65.06 0.31 9041 642920053 XP_008192184.1 1927 2.1e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.05594e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.0e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03396//PF02297//PF13673//PF00159//PF08159//PF03822//PF13508//PF00583//PF08445 Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Cytochrome oxidase c subunit VIb//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide//NUC153 domain//NAF domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein GO:0015992//GO:0019083//GO:0006123//GO:0007165//GO:0042967//GO:0006206//GO:0006351//GO:0006144 proton transport//viral transcription//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//acyl-carrier-protein biosynthetic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0016747//GO:0004129//GO:0003677//GO:0008080//GO:0005179 DNA-directed RNA polymerase activity//transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity//DNA binding//N-acetyltransferase activity//hormone activity GO:0005730//GO:0005739//GO:0005576//GO:0005634//GO:0045277 nucleolus//mitochondrion//extracellular region//nucleus//respiratory chain complex IV KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.29151 BF_2 216.72 1.17 8068 642920053 XP_008192184.1 2013 2.0e-222 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 2.72571e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 2.7e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF00159//PF13673//PF03396//PF02297//PF08112//PF00583//PF13508//PF13302//PF08445//PF08159//PF03822 Pancreatic hormone peptide//Acetyltransferase (GNAT) domain//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Cytochrome oxidase c subunit VIb//ATP synthase epsilon subunit//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//NUC153 domain//NAF domain GO:0015992//GO:0042967//GO:0006810//GO:0006123//GO:0007165//GO:0019083//GO:0006206//GO:0015986//GO:0006144//GO:0006351 proton transport//acyl-carrier-protein biosynthetic process//transport//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//viral transcription//pyrimidine nucleobase metabolic process//ATP synthesis coupled proton transport//purine nucleobase metabolic process//transcription, DNA-templated GO:0042626//GO:0003899//GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0003677 ATPase activity, coupled to transmembrane movement of substances//DNA-directed RNA polymerase activity//cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//DNA binding GO:0005730//GO:0005739//GO:0033178//GO:0005576//GO:0045277//GO:0005634 nucleolus//mitochondrion//proton-transporting two-sector ATPase complex, catalytic domain//extracellular region//respiratory chain complex IV//nucleus KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.29153 BF_2 81.16 0.90 4043 642917906 XP_970904.3 3304 0.0e+00 PREDICTED: probable 3',5'-cyclic phosphodiesterase pde-5 isoform X1 [Tribolium castaneum]>gi|270003323|gb|EEZ99770.1| hypothetical protein TcasGA2_TC002545 [Tribolium castaneum] -- -- -- -- -- K18438 PDE10 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18438 P91119 1631 8.1e-180 Probable 3',5'-cyclic phosphodiesterase pde-5 OS=Caenorhabditis elegans GN=pde-5 PE=3 SV=3 PF01590//PF00233//PF13492//PF13185 GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain GO:0006144//GO:0008152//GO:0007165 purine nucleobase metabolic process//metabolic process//signal transduction GO:0046872//GO:0005515//GO:0004114 metal ion binding//protein binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.29157 BF_2 1093.98 79.34 864 332374938 AEE62610.1 1083 1.5e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03943 NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03943 Q0MQI8 808 4.7e-85 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Gorilla gorilla gorilla GN=NDUFV2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3196 NADH:ubiquinone oxidoreductase, NDUFV2/24 kD subunit Cluster-8309.2916 BF_2 13.00 0.60 1193 189239958 XP_973407.2 1376 2.2e-149 PREDICTED: carboxypeptidase B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04069 758 4.1e-79 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF04952//PF02244//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Carboxypeptidase activation peptide//Zinc carboxypeptidase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004180//GO:0004181//GO:0008270//GO:0016788 carboxypeptidase activity//metallocarboxypeptidase activity//zinc ion binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.29160 BF_2 1107.92 56.81 1103 91080511 XP_975872.1 992 6.7e-105 PREDICTED: V-type proton ATPase subunit D [Tribolium castaneum]>gi|270005793|gb|EFA02241.1| hypothetical protein TcasGA2_TC007903 [Tribolium castaneum] 571550213 XM_394769.5 200 3.24293e-98 PREDICTED: Apis mellifera v-type proton ATPase subunit D 1-like (LOC411295), transcript variant 1, mRNA K02149 ATPeV1D, ATP6M V-type H+-transporting ATPase subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K02149 Q9V7D2 962 8.3e-103 V-type proton ATPase subunit D 1 OS=Drosophila melanogaster GN=Vha36-1 PE=2 SV=1 PF01813//PF05261//PF00542 ATP synthase subunit D//TraM protein, DNA-binding//Ribosomal protein L7/L12 C-terminal domain GO:0006810//GO:0006412//GO:0042254//GO:0000746 transport//translation//ribosome biogenesis//conjugation GO:0003677//GO:0003735//GO:0042626 DNA binding//structural constituent of ribosome//ATPase activity, coupled to transmembrane movement of substances GO:0005840 ribosome KOG1647 Vacuolar H+-ATPase V1 sector, subunit D Cluster-8309.29161 BF_2 881.92 16.64 2504 91092348 XP_971306.1 1591 5.3e-174 PREDICTED: uncharacterized protein LOC659947 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0061025//GO:0046813 membrane fusion//receptor-mediated virion attachment to host cell -- -- GO:0016021//GO:0019031 integral component of membrane//viral envelope -- -- Cluster-8309.29162 BF_2 47.38 0.58 3679 642927357 XP_008195235.1 881 1.7e-91 PREDICTED: glutamate receptor ionotropic, kainate 2-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007268//GO:0006811//GO:0007165 synaptic transmission//ion transport//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.29163 BF_2 193.50 3.81 2411 642937453 XP_008198842.1 569 1.6e-55 PREDICTED: protein tramtrack, beta isoform-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29165 BF_2 12.00 0.49 1316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29168 BF_2 87.00 3.40 1357 91083243 XP_973851.1 1583 2.4e-173 PREDICTED: guanine nucleotide-binding protein subunit beta-2 [Tribolium castaneum]>gi|270007716|gb|EFA04164.1| hypothetical protein TcasGA2_TC014410 [Tribolium castaneum] -- -- -- -- -- K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 P29829 1209 2.3e-131 Guanine nucleotide-binding protein subunit beta-2 OS=Drosophila melanogaster GN=Gbeta76C PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.29169 BF_2 4.00 0.48 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29171 BF_2 99.81 1.08 4150 675381743 KFM74645.1 366 9.8e-32 Zinc finger protein 729, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A0JNB1 314 4.3e-27 Zinc finger protein 227 OS=Bos taurus GN=ZNF227 PE=2 SV=1 PF13465//PF00096//PF07975//PF13912//PF04810//PF00412//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain//C2H2-type zinc finger//Sec23/Sec24 zinc finger//LIM domain//BED zinc finger GO:0006281//GO:0006888//GO:0006886 DNA repair//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.29172 BF_2 66.21 2.11 1600 642936826 XP_008197806.1 1259 1.1e-135 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [Tribolium castaneum]>gi|270000937|gb|EEZ97384.1| hypothetical protein TcasGA2_TC011210 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 1045 2.9e-112 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.29173 BF_2 23.00 16.36 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29176 BF_2 938.00 15.09 2888 -- -- -- -- -- 642937526 XM_008200861.1 124 1.5311e-55 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF09462 Mus7/MMS22 family GO:0031297//GO:0006281//GO:0006974 replication fork processing//DNA repair//cellular response to DNA damage stimulus -- -- GO:0005634 nucleus -- -- Cluster-8309.29179 BF_2 160.73 2.90 2602 642917903 XP_008191376.1 1043 1.9e-110 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 270 3.4e-22 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29181 BF_2 2.00 0.54 442 795111383 XP_011882465.1 178 6.5e-11 PREDICTED: gastrula zinc finger protein xFG20-1-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7KQZ4 133 4.4e-07 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF03470//PF07975 Zinc finger, C2H2 type//Zinc-finger double domain//XS zinc finger domain//TFIIH C1-like domain GO:0006281//GO:0031047 DNA repair//gene silencing by RNA GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.29183 BF_2 6.79 0.87 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29185 BF_2 107.33 2.85 1862 478252475 ENN72897.1 849 4.3e-88 hypothetical protein YQE_10467, partial [Dendroctonus ponderosae] 318037409 NM_001201142.1 54 8.02629e-17 Ictalurus punctatus serine/threonine-protein phosphatase 2a regulatory subunit b' (ptpa), mRNA >gnl|BL_ORD_ID|9527029 Ictalurus punctatus clone CBPN47522 serine/threonine-protein phosphatase 2a regulatory subunit b' (PTPA) mRNA, complete cds K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 651 1.6e-66 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF03095 Phosphotyrosyl phosphate activator (PTPA) protein -- -- GO:0019211 phosphatase activator activity -- -- KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.29186 BF_2 173.83 1.55 4983 688550711 XP_009299041.1 812 2.3e-83 PREDICTED: gastrula zinc finger protein XlCGF57.1-like, partial [Danio rerio] -- -- -- -- -- -- -- -- -- P52742 790 3.3e-82 Zinc finger protein 135 OS=Homo sapiens GN=ZNF135 PE=2 SV=3 PF07776//PF04931//PF06524//PF00096//PF16622//PF13912//PF12131//PF02178//PF13465 Zinc-finger associated domain (zf-AD)//DNA polymerase phi//NOA36 protein//Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger//Protein of unknown function (DUF3586)//AT hook motif//Zinc-finger double domain GO:0006351//GO:0006508//GO:0006260 transcription, DNA-templated//proteolysis//DNA replication GO:0003887//GO:0003677//GO:0004197//GO:0046872//GO:0008270 DNA-directed DNA polymerase activity//DNA binding//cysteine-type endopeptidase activity//metal ion binding//zinc ion binding GO:0042575//GO:0005634 DNA polymerase complex//nucleus -- -- Cluster-8309.29187 BF_2 468.83 8.01 2737 332375098 AEE62690.1 1294 1.6e-139 unknown [Dendroctonus ponderosae]>gi|478257120|gb|ENN77283.1| hypothetical protein YQE_06109, partial [Dendroctonus ponderosae]>gi|546683344|gb|ERL93166.1| hypothetical protein D910_10463 [Dendroctonus ponderosae] -- -- -- -- -- K08343 ATG3 ubiquitin-like-conjugating enzyme ATG3 http://www.genome.jp/dbget-bin/www_bget?ko:K08343 Q6PFS7 1020 3.9e-109 Ubiquitin-like-conjugating enzyme ATG3 OS=Danio rerio GN=atg3 PE=2 SV=1 PF06524//PF12131//PF04931 NOA36 protein//Protein of unknown function (DUF3586)//DNA polymerase phi GO:0006260//GO:0006508//GO:0006351 DNA replication//proteolysis//transcription, DNA-templated GO:0004197//GO:0008270//GO:0003887//GO:0003677 cysteine-type endopeptidase activity//zinc ion binding//DNA-directed DNA polymerase activity//DNA binding GO:0042575//GO:0005634 DNA polymerase complex//nucleus KOG2981 Protein involved in autophagocytosis during starvation Cluster-8309.29188 BF_2 977.51 34.57 1470 642916772 XP_008192547.1 685 3.5e-69 PREDICTED: peptidoglycan-recognition protein LE-like [Tribolium castaneum]>gi|270004832|gb|EFA01280.1| hypothetical protein TcasGA2_TC002790 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9VXN9 410 1.1e-38 Peptidoglycan-recognition protein LE OS=Drosophila melanogaster GN=PGRP-LE PE=1 SV=1 PF01510//PF05093 N-acetylmuramoyl-L-alanine amidase//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0009252//GO:0006807//GO:0009253//GO:0016226 peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process//iron-sulfur cluster assembly GO:0051536//GO:0008745 iron-sulfur cluster binding//N-acetylmuramoyl-L-alanine amidase activity GO:0005737 cytoplasm -- -- Cluster-8309.29189 BF_2 176.82 1.36 5714 91077022 XP_976032.1 550 6.2e-53 PREDICTED: uncharacterized protein LOC655336 [Tribolium castaneum]>gi|270001753|gb|EEZ98200.1| hypothetical protein TcasGA2_TC000630 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00779//PF08064 BTK motif//UME (NUC010) domain GO:0016310//GO:0035556//GO:0009069 phosphorylation//intracellular signal transduction//serine family amino acid metabolic process GO:0004674 protein serine/threonine kinase activity -- -- -- -- Cluster-8309.29191 BF_2 50.13 0.71 3238 642916369 XP_008190992.1 1504 8.4e-164 PREDICTED: TOM1-like protein 2 isoform X1 [Tribolium castaneum]>gi|270004201|gb|EFA00649.1| hypothetical protein TcasGA2_TC003525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRX1 828 8.4e-87 TOM1-like protein 2 OS=Mus musculus GN=Tom1l2 PE=2 SV=1 PF00790//PF03127 VHS domain//GAT domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular KOG1087 Cytosolic sorting protein GGA2/TOM1 Cluster-8309.29194 BF_2 72.00 0.67 4769 189240067 XP_970199.2 2407 2.4e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.21611e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 4.8e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690//PF08040//PF00083//PF05480 Major Facilitator Superfamily//MNLL subunit//Sugar (and other) transporter//Staphylococcus haemolytic protein GO:0006118//GO:0009405//GO:0055085 obsolete electron transport//pathogenesis//transmembrane transport GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.29196 BF_2 239.40 2.34 4564 332375078 AEE62680.1 1122 2.3e-119 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14458 MOGAT1, MGAT1 2-acylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14458 Q70VZ7 706 1.7e-72 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.29199 BF_2 115.69 0.71 7113 332375078 AEE62680.1 1234 3.8e-132 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14458 MOGAT1, MGAT1 2-acylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14458 Q70VZ7 706 2.6e-72 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982//PF01781 Diacylglycerol acyltransferase//Ribosomal L38e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0016747//GO:0003735 transferase activity, transferring acyl groups other than amino-acyl groups//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.29200 BF_2 132.98 3.26 1992 642923366 XP_973695.2 1701 7.4e-187 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.29201 BF_2 37.84 0.85 2155 642923366 XP_973695.2 486 6.2e-46 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29202 BF_2 104.04 2.93 1774 642920753 XP_008192548.1 1472 2.4e-160 PREDICTED: probable asparagine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270005193|gb|EFA01641.1| hypothetical protein TcasGA2_TC007211 [Tribolium castaneum] -- -- -- -- -- K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q96I59 1088 3.3e-117 Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens GN=NARS2 PE=1 SV=3 PF01336//PF01409//PF00152 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N) GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0003676//GO:0000166//GO:0004812//GO:0005524//GO:0000049 nucleic acid binding//nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//tRNA binding GO:0005737 cytoplasm KOG0554 Asparaginyl-tRNA synthetase (mitochondrial) Cluster-8309.29203 BF_2 301.61 8.18 1830 546684751 ERL94361.1 1480 2.9e-161 hypothetical protein D910_11641 [Dendroctonus ponderosae] 462299794 APGK01051198.1 45 7.9417e-12 Dendroctonus ponderosae Seq01051208, whole genome shotgun sequence -- -- -- -- Q7PIR5 662 8.4e-68 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083//PF05770 Major Facilitator Superfamily//Sugar (and other) transporter//Inositol 1, 3, 4-trisphosphate 5/6-kinase GO:0055085//GO:0032957 transmembrane transport//inositol trisphosphate metabolic process GO:0022857//GO:0052726//GO:0005524//GO:0047325//GO:0052725//GO:0000287 transmembrane transporter activity//inositol-1,3,4-trisphosphate 5-kinase activity//ATP binding//inositol tetrakisphosphate 1-kinase activity//inositol-1,3,4-trisphosphate 6-kinase activity//magnesium ion binding GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.29204 BF_2 18.58 1.18 946 270008326 EFA04774.1 241 7.0e-18 hypothetical protein TcasGA2_TC030735 [Tribolium castaneum] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 Q9JI18 189 3.1e-13 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.29211 BF_2 118.08 1.61 3363 91080709 XP_975318.1 1500 2.5e-163 PREDICTED: protein sly1 homolog [Tribolium castaneum]>gi|270005472|gb|EFA01920.1| hypothetical protein TcasGA2_TC007530 [Tribolium castaneum] 820837626 XM_003690680.2 92 1.09802e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 1253 4.6e-136 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF16519//PF00804//PF00995//PF05739//PF00992 Tetramerisation domain of TRPM//Syntaxin//Sec1 family//SNARE domain//Troponin GO:0051262//GO:0006904//GO:0016192 protein tetramerization//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0005861 membrane//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.29215 BF_2 20.00 6.13 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29217 BF_2 126.00 4.22 1535 546673846 ERL85378.1 536 7.0e-52 hypothetical protein D910_02798 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09239 Topoisomerase VI B subunit, transducer GO:0006265 DNA topological change GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity -- -- -- -- Cluster-8309.29220 BF_2 35.43 0.50 3268 642932613 XP_968153.2 4055 0.0e+00 PREDICTED: uncharacterized protein LOC656535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.29222 BF_2 166.00 1.84 4053 642915933 XP_008190817.1 1231 4.8e-132 PREDICTED: ras-related protein Rap-2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96D21 358 3.3e-32 GTP-binding protein Rhes OS=Homo sapiens GN=RASD2 PE=1 SV=1 PF00071//PF00025//PF04670//PF00503//PF01926//PF03193//PF08477 Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0395 Ras-related GTPase Cluster-8309.29223 BF_2 263.73 2.21 5273 91078468 XP_967964.1 2089 2.0e-231 PREDICTED: integral membrane protein GPR180 isoform X1 [Tribolium castaneum]>gi|270003859|gb|EFA00307.1| hypothetical protein TcasGA2_TC003142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q976I0 277 1.1e-22 Peptidyl-tRNA hydrolase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=pth PE=3 SV=1 PF10192//PF01981//PF02891//PF05051 Rhodopsin-like GPCR transmembrane domain//Peptidyl-tRNA hydrolase PTH2//MIZ/SP-RING zinc finger//Cytochrome C oxidase copper chaperone (COX17) GO:0006825//GO:0007186//GO:0019236 copper ion transport//G-protein coupled receptor signaling pathway//response to pheromone GO:0016531//GO:0005507//GO:0004045//GO:0008270 copper chaperone activity//copper ion binding//aminoacyl-tRNA hydrolase activity//zinc ion binding GO:0005758 mitochondrial intermembrane space KOG3282 Uncharacterized conserved protein Cluster-8309.29225 BF_2 18.30 0.64 1483 91078618 XP_967724.1 587 8.3e-58 PREDICTED: cytochrome P450 4d2 [Tribolium castaneum]>gi|270004875|gb|EFA01323.1| cytochrome P450 4BR3 [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 338 2.5e-30 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0005506//GO:0020037//GO:0004497//GO:0016705//GO:0009055 iron ion binding//heme binding//monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- -- -- Cluster-8309.29226 BF_2 81.00 3.88 1161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16557 CUT1-like DNA-binding domain of SATB -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.29227 BF_2 103.82 1.55 3097 270009865 EFA06313.1 1914 2.3e-211 hypothetical protein TcasGA2_TC009182 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REG1 740 1.3e-76 Squamous cell carcinoma antigen recognized by T-cells 3 OS=Pongo abelii GN=SART3 PE=2 SV=1 PF12052//PF05843//PF00076//PF16367//PF13174//PF08777 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Suppressor of forked protein (Suf)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Tetratricopeptide repeat//RNA binding motif GO:0006397//GO:0006816//GO:0070588 mRNA processing//calcium ion transport//calcium ion transmembrane transport GO:0003723//GO:0005515//GO:0003676//GO:0005245 RNA binding//protein binding//nucleic acid binding//voltage-gated calcium channel activity GO:0005634//GO:0005891 nucleus//voltage-gated calcium channel complex KOG0128 RNA-binding protein SART3 (RRM superfamily) Cluster-8309.29229 BF_2 67.00 3.66 1053 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.2923 BF_2 16.00 0.39 2015 833654169 AKM28424.1 1420 2.9e-154 fatty acid synthase 2 [Aphis gossypii] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 974 6.2e-104 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00975//PF00106 Thioesterase domain//short chain dehydrogenase GO:0008152//GO:0009058 metabolic process//biosynthetic process GO:0016788//GO:0016491 hydrolase activity, acting on ester bonds//oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.29238 BF_2 7.55 0.34 1225 332372870 AEE61577.1 251 6.2e-19 unknown [Dendroctonus ponderosae]>gi|478256263|gb|ENN76453.1| hypothetical protein YQE_06907, partial [Dendroctonus ponderosae]>gi|546679245|gb|ERL89739.1| hypothetical protein D910_07100 [Dendroctonus ponderosae] -- -- -- -- -- K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q9D1L0 166 1.8e-10 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Mus musculus GN=Chchd2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4090 Uncharacterized conserved protein Cluster-8309.29239 BF_2 83.28 0.67 5503 642929544 XP_975258.3 1001 3.0e-105 PREDICTED: KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q5VWX1 417 6.5e-39 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Homo sapiens GN=KHDRBS2 PE=1 SV=1 PF00013//PF13014//PF06667 KH domain//KH domain//Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated GO:0003723 RNA binding -- -- -- -- Cluster-8309.29241 BF_2 345.41 2.26 6677 642910859 XP_008193438.1 1525 6.4e-166 PREDICTED: mitogen-activated protein kinase 14B-like [Tribolium castaneum] 749732005 XM_011139608.1 229 1.52303e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 4.8e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF06293//PF00069//PF02434//PF01762//PF07714//PF13414 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Fringe-like//Galactosyltransferase//Protein tyrosine kinase//TPR repeat GO:0006486//GO:0006468 protein glycosylation//protein phosphorylation GO:0016773//GO:0008378//GO:0004672//GO:0005524//GO:0016757//GO:0005515 phosphotransferase activity, alcohol group as acceptor//galactosyltransferase activity//protein kinase activity//ATP binding//transferase activity, transferring glycosyl groups//protein binding GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.29242 BF_2 163.38 0.93 7662 642911971 XP_008199044.1 6534 0.0e+00 PREDICTED: endoribonuclease Dcr-1 [Tribolium castaneum]>gi|642911973|ref|XP_008199045.1| PREDICTED: endoribonuclease Dcr-1 [Tribolium castaneum] 755864608 XM_005179866.2 182 2.34388e-87 PREDICTED: Musca domestica endoribonuclease Dcr-1 (LOC101896691), mRNA K11592 DICER1, DCR1 endoribonuclease Dicer http://www.genome.jp/dbget-bin/www_bget?ko:K11592 Q9VCU9 1952 9.2e-217 Endoribonuclease Dcr-1 OS=Drosophila melanogaster GN=Dcr-1 PE=1 SV=1 PF00636//PF02723//PF03368//PF02170//PF14622 Ribonuclease III domain//Non-structural protein NS3/Small envelope protein E//Dicer dimerisation domain//PAZ domain//Ribonuclease-III-like GO:0051252//GO:0006396 regulation of RNA metabolic process//RNA processing GO:0005515//GO:0016891//GO:0003723//GO:0004525 protein binding//endoribonuclease activity, producing 5'-phosphomonoesters//RNA binding//ribonuclease III activity GO:0016020 membrane KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.29243 BF_2 6026.69 78.81 3486 91088287 XP_968620.1 2906 0.0e+00 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [Tribolium castaneum]>gi|270012778|gb|EFA09226.1| hypothetical protein TcasGA2_TC006271 [Tribolium castaneum] 830244945 XM_012734906.1 514 0 PREDICTED: Condylura cristata succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), mRNA K00234 SDHA, SDH1 succinate dehydrogenase (ubiquinone) flavoprotein subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00234 Q9YHT1 2618 2.5e-294 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Gallus gallus GN=SDHA PE=1 SV=2 PF01494//PF02910//PF07992//PF01266//PF01134 FAD binding domain//Fumarate reductase flavoprotein C-term//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Glucose inhibited division protein A GO:0008033//GO:0055114//GO:0022900//GO:0006099 tRNA processing//oxidation-reduction process//electron transport chain//tricarboxylic acid cycle GO:0016491//GO:0071949//GO:0016627//GO:0050660 oxidoreductase activity//FAD binding//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding -- -- KOG2403 Succinate dehydrogenase, flavoprotein subunit Cluster-8309.29244 BF_2 314.06 2.77 5023 642938700 XP_008196774.1 1653 6.9e-181 PREDICTED: PWWP domain-containing protein 2A-like isoform X1 [Tribolium castaneum]>gi|270015802|gb|EFA12250.1| hypothetical protein TcasGA2_TC016110 [Tribolium castaneum] -- -- -- -- -- K10732 GINS1, PSF1 GINS complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10732 Q14691 515 2.6e-50 DNA replication complex GINS protein PSF1 OS=Homo sapiens GN=GINS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3303 Predicted alpha-helical protein, potentially involved in replication/repair Cluster-8309.29245 BF_2 273.39 3.59 3472 478252986 ENN73368.1 2585 4.0e-289 hypothetical protein YQE_10018, partial [Dendroctonus ponderosae] 847107195 XM_012958238.1 37 4.25541e-07 PREDICTED: Xenopus (Silurana) tropicalis piwi-like RNA-mediated gene silencing 4 (piwil4), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 Q7PLK0 1621 1.0e-178 Protein argonaute-3 OS=Drosophila melanogaster GN=AGO3 PE=1 SV=3 PF02171//PF02170 Piwi domain//PAZ domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.29246 BF_2 681.51 7.14 4280 642911817 XP_008200757.1 2677 1.1e-299 PREDICTED: histone-arginine methyltransferase CARMER isoform X1 [Tribolium castaneum]>gi|270014548|gb|EFA10996.1| hypothetical protein TcasGA2_TC004581 [Tribolium castaneum] -- -- -- -- -- K05931 CARM1, PRMT4 histone-arginine methyltransferase CARM1 http://www.genome.jp/dbget-bin/www_bget?ko:K05931 Q174R2 1725 1.1e-190 Histone-arginine methyltransferase CARMER OS=Aedes aegypti GN=CARM1 PE=3 SV=1 PF08241//PF05175//PF03602//PF05185 Methyltransferase domain//Methyltransferase small domain//Conserved hypothetical protein 95//PRMT5 arginine-N-methyltransferase GO:0008152//GO:0006479//GO:0031167 metabolic process//protein methylation//rRNA methylation GO:0008168 methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.29247 BF_2 1.00 0.60 353 531445261 AGT57839.1 220 7.0e-16 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 177 2.8e-12 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29248 BF_2 146.45 0.96 6661 478256920 ENN77089.1 1979 1.4e-218 hypothetical protein YQE_06424, partial [Dendroctonus ponderosae] -- -- -- -- -- K09257 NFKBIL2 NF-kappa-B inhibitor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09257 Q9VSA4 748 3.3e-77 Tonsoku-like protein OS=Drosophila melanogaster GN=CG7457 PE=1 SV=1 PF13174//PF13181//PF13606//PF13176//PF13414//PF00515//PF13374//PF02827//PF00023 Tetratricopeptide repeat//Tetratricopeptide repeat//Ankyrin repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Ankyrin repeat GO:0045859//GO:0006469 regulation of protein kinase activity//negative regulation of protein kinase activity GO:0005515//GO:0004862 protein binding//cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG4177 Ankyrin Cluster-8309.29253 BF_2 18.00 0.90 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29254 BF_2 567.13 6.23 4095 642913301 XP_008201476.1 1372 2.2e-148 PREDICTED: chymotrypsin-like elastase family member 2A isoform X2 [Tribolium castaneum]>gi|270002775|gb|EEZ99222.1| serine protease P16 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18824 474 1.2e-45 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130//PF00089 CD36 family//Trypsin GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.29256 BF_2 101.00 6.35 953 91092096 XP_971769.1 652 1.5e-65 PREDICTED: ribosomal RNA-processing protein 7 homolog A [Tribolium castaneum]>gi|270004673|gb|EFA01121.1| hypothetical protein TcasGA2_TC010334 [Tribolium castaneum] -- -- -- -- -- K14545 RRP7 ribosomal RNA-processing protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14545 Q5RA17 435 9.2e-42 Ribosomal RNA-processing protein 7 homolog A OS=Pongo abelii GN=RRP7A PE=2 SV=1 PF00076//PF04928 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Poly(A) polymerase central domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003676 polynucleotide adenylyltransferase activity//nucleic acid binding -- -- KOG4008 rRNA processing protein RRP7 Cluster-8309.29257 BF_2 302.56 8.34 1804 478257213 ENN77376.1 2060 1.6e-228 hypothetical protein YQE_06201, partial [Dendroctonus ponderosae] -- -- -- -- -- K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q6TGS6 1969 2.3e-219 Tyrosine--tRNA ligase, cytoplasmic OS=Danio rerio GN=yars PE=2 SV=2 PF01588//PF00579//PF08039 Putative tRNA binding domain//tRNA synthetases class I (W and Y)//Mitochondrial proteolipid GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000049//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//tRNA binding//nucleotide binding//ATP binding GO:0005739 mitochondrion KOG2144 Tyrosyl-tRNA synthetase, cytoplasmic Cluster-8309.29259 BF_2 191.84 2.49 3510 642915779 XP_008200075.1 2249 3.7e-250 PREDICTED: uncharacterized protein LOC103314829 [Tribolium castaneum]>gi|270003127|gb|EEZ99574.1| hypothetical protein TcasGA2_TC001560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02525 135 2.1e-06 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00096//PF13912//PF07776 Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.2926 BF_2 2.00 0.35 523 220172363 ACL79884.1 357 1.4e-31 putative articulin p60 [Rimicaris exoculata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29260 BF_2 109.86 0.76 6316 91083737 XP_970914.1 1523 1.0e-165 PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|642924379|ref|XP_008194272.1| PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|270007890|gb|EFA04338.1| hypothetical protein TcasGA2_TC014632 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 721 4.2e-74 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF00155//PF08115//PF11095//PF02854//PF04834 Aminotransferase class I and II//SFI toxin family//Gem-associated protein 7 (Gemin7)//MIF4G domain//Early E3 14.5 kDa protein GO:0016070//GO:0009405//GO:0009966//GO:0009058 RNA metabolic process//pathogenesis//regulation of signal transduction//biosynthetic process GO:0030170//GO:0005515//GO:0003723//GO:0003677 pyridoxal phosphate binding//protein binding//RNA binding//DNA binding GO:0016021//GO:0032797//GO:0005576 integral component of membrane//SMN complex//extracellular region KOG0259 Tyrosine aminotransferase Cluster-8309.29261 BF_2 5.00 1.48 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02477 Nucleocapsid N protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.29262 BF_2 595.00 44.30 849 91087541 XP_970326.1 181 5.7e-11 PREDICTED: V-type proton ATPase subunit G [Tribolium castaneum]>gi|270009446|gb|EFA05894.1| hypothetical protein TcasGA2_TC008706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XZH6 132 1.1e-06 V-type proton ATPase subunit G OS=Drosophila melanogaster GN=Vha13 PE=3 SV=1 PF03938//PF04111//PF01086//PF03040//PF01442//PF00833 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//Clathrin light chain//CemA family//Apolipoprotein A1/A4/E domain//Ribosomal S17 GO:0042157//GO:0006869//GO:0006412//GO:0042254//GO:0006914//GO:0016192//GO:0006886 lipoprotein metabolic process//lipid transport//translation//ribosome biogenesis//autophagy//vesicle-mediated transport//intracellular protein transport GO:0008289//GO:0003735//GO:0051082//GO:0005198 lipid binding//structural constituent of ribosome//unfolded protein binding//structural molecule activity GO:0005576//GO:0005840//GO:0005622//GO:0030130//GO:0016021//GO:0030132 extracellular region//ribosome//intracellular//clathrin coat of trans-Golgi network vesicle//integral component of membrane//clathrin coat of coated pit -- -- Cluster-8309.29263 BF_2 2.63 0.38 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03396 Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0019083//GO:0006206//GO:0006351//GO:0006144 viral transcription//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.29265 BF_2 1120.09 13.90 3657 189234163 XP_967233.2 958 1.9e-100 PREDICTED: receptor expression-enhancing protein 4-like [Tribolium castaneum] 482684005 XM_001361907.3 101 1.18662e-42 Drosophila pseudoobscura pseudoobscura GA30269, transcript variant B (Dpse\GA30269), mRNA K17338 REEP1_2_3_4 receptor expression-enhancing protein 1/2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17338 Q8VCD6 543 1.1e-53 Receptor expression-enhancing protein 2 OS=Mus musculus GN=Reep2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.29266 BF_2 90.14 15.21 535 91089079 XP_971357.1 280 1.2e-22 PREDICTED: DNA-directed RNA polymerase III subunit RPC9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VHM6 126 3.5e-06 DNA-directed RNA polymerase III subunit RPC9 OS=Rattus norvegicus GN=Crcp PE=2 SV=1 PF03874 RNA polymerase Rpb4 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.29268 BF_2 505.23 12.69 1953 642925360 XP_008194517.1 1929 2.6e-213 PREDICTED: adiponectin receptor protein isoform X1 [Tribolium castaneum]>gi|642925362|ref|XP_008194518.1| PREDICTED: adiponectin receptor protein isoform X1 [Tribolium castaneum]>gi|270008824|gb|EFA05272.1| hypothetical protein TcasGA2_TC015429 [Tribolium castaneum] 332372817 BT126587.1 431 0 Dendroctonus ponderosae clone DPO1421_D03 unknown mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 1453 1.7e-159 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF00060//PF03006 Ligand-gated ion channel//Haemolysin-III related GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.29269 BF_2 1086.45 28.68 1872 546680534 ERL90794.1 1833 3.4e-202 hypothetical protein D910_08140 [Dendroctonus ponderosae] 332372817 BT126587.1 453 0 Dendroctonus ponderosae clone DPO1421_D03 unknown mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 1470 1.7e-161 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF00060//PF03006 Ligand-gated ion channel//Haemolysin-III related GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.29270 BF_2 20.91 0.84 1331 478259433 ENN79323.1 390 5.2e-35 hypothetical protein YQE_04232, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N2E2 151 1.1e-08 von Willebrand factor D and EGF domain-containing protein OS=Homo sapiens GN=VWDE PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29271 BF_2 231.85 2.01 5114 91084209 XP_968139.1 2200 2.6e-244 PREDICTED: uncharacterized protein LOC656520 [Tribolium castaneum]>gi|642925194|ref|XP_008194464.1| PREDICTED: uncharacterized protein LOC656520 [Tribolium castaneum]>gi|270008783|gb|EFA05231.1| hypothetical protein TcasGA2_TC015377 [Tribolium castaneum] -- -- -- -- -- K04458 PTPRR receptor-type tyrosine-protein phosphatase R http://www.genome.jp/dbget-bin/www_bget?ko:K04458 P54829 272 3.9e-22 Tyrosine-protein phosphatase non-receptor type 5 OS=Homo sapiens GN=PTPN5 PE=1 SV=4 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.29272 BF_2 98.00 2.72 1796 642940140 XP_008192185.1 221 2.8e-15 PREDICTED: uncharacterized protein LOC103312673 [Tribolium castaneum]>gi|270017232|gb|EFA13678.1| hypothetical protein TcasGA2_TC001394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29273 BF_2 116.63 0.97 5312 270012222 EFA08670.1 2246 1.3e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06974//PF03007 Protein of unknown function (DUF1298)//Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0046486//GO:0042967//GO:0045017 glycerolipid metabolic process//acyl-carrier-protein biosynthetic process//glycerolipid biosynthetic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.29274 BF_2 955.70 5.39 7701 642923476 XP_008193526.1 2358 1.9e-262 PREDICTED: nuclear pore complex protein Nup214 [Tribolium castaneum] -- -- -- -- -- K14863 YTM1, WDR12 ribosome biogenesis protein YTM1 http://www.genome.jp/dbget-bin/www_bget?ko:K14863 Q17BB0 1090 8.3e-117 Ribosome biogenesis protein WDR12 homolog OS=Aedes aegypti GN=AAEL005041 PE=3 SV=1 PF00400//PF08024 WD domain, G-beta repeat//Ant antimicrobial peptide GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515 protein binding GO:0005576 extracellular region KOG0313 Microtubule binding protein YTM1 (contains WD40 repeats) Cluster-8309.29277 BF_2 16.47 0.32 2442 91083611 XP_969629.1 775 2.2e-79 PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|642924148|ref|XP_008194028.1| PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|270006834|gb|EFA03282.1| hypothetical protein TcasGA2_TC013217 [Tribolium castaneum] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 512 2.8e-50 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.29278 BF_2 19.22 0.41 2269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29280 BF_2 4.03 1.23 424 659495114 AID66668.1 354 2.5e-31 short-chain specific acyl-CoA dehydrogenase [Agrotis segetum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q07417 290 2.7e-25 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 PF00441 Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.29281 BF_2 29.52 0.40 3386 546685504 ERL95002.1 827 2.8e-85 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29283 BF_2 173.29 1.16 6515 642936804 XP_008199623.1 6018 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.3e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF00307//PF00910//PF08702//PF07926//PF10473//PF06160//PF13851//PF00004//PF16716//PF01832//PF07728//PF01695//PF04111 Calponin homology (CH) domain//RNA helicase//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Growth-arrest specific micro-tubule binding//ATPase family associated with various cellular activities (AAA)//Bone marrow stromal antigen 2//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Autophagy protein Apg6 GO:0006525//GO:0007165//GO:0051258//GO:0006914//GO:0006606//GO:0006568//GO:0006558//GO:0042207//GO:0018874//GO:0051607//GO:0000921//GO:0048870//GO:0006560//GO:0030168 arginine metabolic process//signal transduction//protein polymerization//autophagy//protein import into nucleus//tryptophan metabolic process//L-phenylalanine metabolic process//styrene catabolic process//benzoate metabolic process//defense response to virus//septin ring assembly//cell motility//proline metabolic process//platelet activation GO:0005524//GO:0008134//GO:0045502//GO:0016887//GO:0005102//GO:0003723//GO:0004040//GO:0005515//GO:0030674//GO:0042803//GO:0003724 ATP binding//transcription factor binding//dynein binding//ATPase activity//receptor binding//RNA binding//amidase activity//protein binding//protein binding, bridging//protein homodimerization activity//RNA helicase activity GO:0016021//GO:0031514//GO:0005940//GO:0005577//GO:0030286//GO:0005667 integral component of membrane//motile cilium//septin ring//fibrinogen complex//dynein complex//transcription factor complex -- -- Cluster-8309.29285 BF_2 10.84 0.66 970 546681721 ERL91758.1 188 1.0e-11 hypothetical protein D910_09084, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29286 BF_2 194.14 7.58 1358 91078340 XP_973522.1 1336 1.1e-144 PREDICTED: palmitoyltransferase ZDHHC3 [Tribolium castaneum]>gi|270003971|gb|EFA00419.1| hypothetical protein TcasGA2_TC003270 [Tribolium castaneum] 808125672 XM_012310529.1 179 1.8933e-86 PREDICTED: Bombus terrestris palmitoyltransferase ZDHHC3 (LOC100642519), mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9NYG2 863 3.1e-91 Palmitoyltransferase ZDHHC3 OS=Homo sapiens GN=ZDHHC3 PE=1 SV=2 PF01529//PF03600 DHHC palmitoyltransferase//Citrate transporter GO:0055085 transmembrane transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0016021 integral component of membrane KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.29289 BF_2 18.00 31.36 291 226968624 YP_002808573.1 474 2.1e-45 cytochrome b [Scylla paramamosain]>gi|225697860|gb|ACO07227.1| cytochrome b [Scylla paramamosain]>gi|403311099|gb|AFR34058.1| cytochrome b (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 291 2.02812e-149 Scylla paramamosain mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 Q9MDZ9 396 9.4e-38 Cytochrome b OS=Drosophila simulans GN=mt:Cyt-b PE=3 SV=1 -- -- GO:0022904//GO:0006118 respiratory electron transport chain//obsolete electron transport GO:0016491//GO:0046872//GO:0009055 oxidoreductase activity//metal ion binding//electron carrier activity GO:0016021//GO:0070469//GO:0005739 integral component of membrane//respiratory chain//mitochondrion KOG4663 Cytochrome b Cluster-8309.29290 BF_2 3933.22 46.88 3797 646712353 KDR17135.1 1800 4.7e-198 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial [Zootermopsis nevadensis] 755992161 XM_011314822.1 149 2.55702e-69 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 1401 3.6e-153 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00549 CoA-ligase GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.29291 BF_2 17.85 0.55 1647 642918534 XP_008191512.1 363 8.6e-32 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 82 1.92765e-32 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- O01761 139 3.4e-07 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF02570 Immunoglobulin domain//Precorrin-8X methylmutase GO:0009236//GO:0015994 cobalamin biosynthetic process//chlorophyll metabolic process GO:0005515//GO:0016993 protein binding//precorrin-8X methylmutase activity -- -- -- -- Cluster-8309.29293 BF_2 383.00 5.17 3388 642910465 XP_008200225.1 441 1.6e-40 PREDICTED: uncharacterized protein LOC103314871 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03810 Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0008536 Ran GTPase binding -- -- -- -- Cluster-8309.29294 BF_2 873.44 15.66 2621 642916167 XP_008190914.1 944 5.9e-99 PREDICTED: uncharacterized protein LOC103312328 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29295 BF_2 105.48 1.65 2969 270014518 EFA10966.1 358 5.9e-31 hypothetical protein TcasGA2_TC004128 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.29296 BF_2 78.57 1.97 1955 642930026 XP_008196217.1 1535 1.3e-167 PREDICTED: homothorax isoform X1 [Tribolium castaneum] 675893071 XM_009033790.1 110 6.24956e-48 Helobdella robusta hypothetical protein mRNA K15613 MEIS1 homeobox protein Meis1 http://www.genome.jp/dbget-bin/www_bget?ko:K15613 O46339 1130 4.9e-122 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.293 BF_2 4.00 0.66 540 701335820 XP_009980506.1 243 2.3e-18 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial, partial [Tauraco erythrolophus] 761231940 KM881643.1 540 0 Oryza officinalis chloroplast, complete genome K03940 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03940 Q6ENH0 484 1.1e-47 NAD(P)H-quinone oxidoreductase subunit K, chloroplastic OS=Oryza nivara GN=ndhK PE=3 SV=2 PF00507//PF03661 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3//Uncharacterised protein family (UPF0121) GO:0006120//GO:0006744//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//proton transport//oxidation-reduction process GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016021 integral component of membrane KOG1687 NADH-ubiquinone oxidoreductase, NUFS7/PSST/20 kDa subunit Cluster-8309.29301 BF_2 21.88 1.11 1110 546680487 ERL90753.1 191 5.1e-12 hypothetical protein D910_08100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29302 BF_2 505.45 17.10 1524 478259251 ENN79153.1 428 2.3e-39 hypothetical protein YQE_04339, partial [Dendroctonus ponderosae]>gi|546678413|gb|ERL89036.1| hypothetical protein D910_06414 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4MPK3 202 1.5e-14 Protein kintoun OS=Drosophila willistoni GN=Ppi20 PE=3 SV=1 PF03286 Pox virus Ag35 surface protein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.29304 BF_2 14.26 1.73 632 642919827 XP_001814264.2 241 4.6e-18 PREDICTED: vascular endothelial growth factor A-A-like [Tribolium castaneum]>gi|270005397|gb|EFA01845.1| hypothetical protein TcasGA2_TC007448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.29307 BF_2 101.02 0.90 4991 642937100 XP_008198691.1 1294 2.9e-139 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 759 1.3e-78 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.29308 BF_2 91.76 0.87 4698 642920993 XP_008192643.1 2739 7.6e-307 PREDICTED: otopetrin-2 isoform X1 [Tribolium castaneum]>gi|270006154|gb|EFA02602.1| hypothetical protein TcasGA2_TC008321 [Tribolium castaneum] 768413017 XM_011570309.1 246 3.79315e-123 PREDICTED: Plutella xylostella otopetrin-2 (LOC105398248), mRNA -- -- -- -- Q7RTS6 203 3.6e-14 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF06783//PF04689 Uncharacterised protein family (UPF0239)//DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.29309 BF_2 48.00 2.68 1037 194320502 ACF48469.1 684 3.3e-69 cathepsin L [Triatoma brasiliensis] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 624 1.2e-63 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.2931 BF_2 7.00 0.34 1137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29316 BF_2 401.19 18.41 1199 91082061 XP_972013.1 763 2.6e-78 PREDICTED: nucleoporin NUP53 [Tribolium castaneum]>gi|270007411|gb|EFA03859.1| hypothetical protein TcasGA2_TC013975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFH5 259 3.0e-21 Nucleoporin NUP53 OS=Homo sapiens GN=NUP35 PE=1 SV=1 PF02458 Transferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG4285 Mitotic phosphoprotein Cluster-8309.29317 BF_2 24.00 4.71 500 -- -- -- -- -- 380041533 JQ407437.1 281 1.32972e-143 Austinograea rodriguezensis 28S large subunit ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29318 BF_2 162.00 22.90 583 270010451 EFA06899.1 789 1.2e-81 hypothetical protein TcasGA2_TC009846 [Tribolium castaneum] 801393574 XM_012202706.1 111 4.97004e-49 PREDICTED: Atta cephalotes 5'-3' exoribonuclease 2 homolog (LOC105621236), mRNA K12619 XRN2, RAT1 5'-3' exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12619 Q9DBR1 671 2.4e-69 5'-3' exoribonuclease 2 OS=Mus musculus GN=Xrn2 PE=1 SV=1 PF03615//PF03159 GCM motif protein//XRN 5'-3' exonuclease N-terminus GO:0006355 regulation of transcription, DNA-templated GO:0004527//GO:0003676//GO:0003677 exonuclease activity//nucleic acid binding//DNA binding -- -- KOG2044 5'-3' exonuclease HKE1/RAT1 Cluster-8309.29319 BF_2 58.00 6.01 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29320 BF_2 536.07 3.31 7059 642939955 XP_008200728.1 3180 0.0e+00 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.4e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF02214//PF00617//PF04900 BTB/POZ domain//RasGEF domain//Fcf1 GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085 guanyl-nucleotide exchange factor activity GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29321 BF_2 288.50 1.66 7566 642939957 XP_008200788.1 3180 0.0e+00 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939959|ref|XP_008200850.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939961|ref|XP_008200899.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939963|ref|XP_008200939.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939965|ref|XP_008200984.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939967|ref|XP_008201036.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.5e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF04900//PF00617//PF00536//PF02214//PF07647 Fcf1//RasGEF domain//SAM domain (Sterile alpha motif)//BTB/POZ domain//SAM domain (Sterile alpha motif) GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29325 BF_2 83.62 0.48 7537 642939957 XP_008200788.1 3180 0.0e+00 PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939959|ref|XP_008200850.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939961|ref|XP_008200899.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939963|ref|XP_008200939.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939965|ref|XP_008200984.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum]>gi|642939967|ref|XP_008201036.1| PREDICTED: breast cancer anti-estrogen resistance protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 484 1.5e-46 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF07647//PF00536//PF02214//PF00617//PF04900 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//BTB/POZ domain//RasGEF domain//Fcf1 GO:0043087//GO:0007264//GO:0051260 regulation of GTPase activity//small GTPase mediated signal transduction//protein homooligomerization GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.29326 BF_2 115.44 6.22 1063 642936884 XP_969823.3 473 9.8e-45 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 214 4.4e-16 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29327 BF_2 21.66 0.85 1359 270001017 EEZ97464.1 324 2.4e-27 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 258 4.4e-21 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137//PF07964 Adenosine-deaminase (editase) domain//Rec10 / Red1 GO:0006144//GO:0051598//GO:0007131//GO:0006807//GO:0006396 purine nucleobase metabolic process//meiotic recombination checkpoint//reciprocal meiotic recombination//nitrogen compound metabolic process//RNA processing GO:0003723//GO:0005198//GO:0004000 RNA binding//structural molecule activity//adenosine deaminase activity -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.29329 BF_2 24.75 0.43 2716 642923611 XP_972526.2 825 3.8e-85 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X1 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.16046e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 625 2.4e-63 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.29330 BF_2 177.00 6.09 1503 642922640 XP_008193258.1 720 3.2e-73 PREDICTED: probable RNA polymerase II nuclear localization protein SLC7A6OS isoform X2 [Tribolium castaneum]>gi|270007526|gb|EFA03974.1| hypothetical protein TcasGA2_TC014121 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2BDB7 163 5.0e-10 Probable RNA polymerase II nuclear localization protein SLC7A6OS OS=Xenopus laevis GN=slc7a6os PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29332 BF_2 54.43 0.47 5112 642938910 XP_008195559.1 1869 6.3e-206 PREDICTED: DENN domain-containing protein 1B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 912 2.4e-96 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.29334 BF_2 26.03 1.19 1204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29335 BF_2 134.65 1.69 3621 478251486 ENN71949.1 495 9.4e-47 hypothetical protein YQE_11383, partial [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q08DK4 299 2.1e-25 Mitochondrial glutamate carrier 1 OS=Bos taurus GN=SLC25A22 PE=2 SV=1 PF00519 Papillomavirus helicase GO:0006260 DNA replication GO:0004003//GO:0003677//GO:0005524 ATP-dependent DNA helicase activity//DNA binding//ATP binding GO:0005657 replication fork KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.29338 BF_2 889.00 37.01 1292 -- -- -- -- -- 462473955 APGK01001494.1 40 3.3471e-09 Dendroctonus ponderosae Seq01001494, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29339 BF_2 192.28 1.66 5134 642930106 XP_008196254.1 1363 3.0e-147 PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum]>gi|642930108|ref|XP_008196255.1| PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q5R7H0 1005 4.0e-107 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Pongo abelii GN=DHTKD1 PE=2 SV=1 PF00676//PF09412 Dehydrogenase E1 component//Endoribonuclease XendoU GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.29342 BF_2 1.00 2.73 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29343 BF_2 66.35 0.56 5281 270008951 EFA05399.1 702 1.4e-70 hypothetical protein TcasGA2_TC015571 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 409 5.3e-38 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29344 BF_2 57.75 0.81 3271 270008949 EFA05397.1 1203 6.8e-129 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97279 642 3.1e-65 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Mesocricetus auratus GN=ITIH2 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29347 BF_2 44.87 0.34 5772 270008949 EFA05397.1 1318 5.5e-142 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 704 3.6e-72 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF13855//PF06385 Leucine rich repeat//Baculovirus LEF-11 protein GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-8309.29349 BF_2 85.74 1.48 2714 270008949 EFA05397.1 1205 3.3e-129 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 630 6.4e-64 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29351 BF_2 16.00 1.98 625 391340837 XP_003744742.1 438 6.6e-41 PREDICTED: muscle LIM protein Mlp84B-like [Metaseiulus occidentalis] -- -- -- -- -- K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 P53777 330 9.1e-30 Muscle LIM protein 1 OS=Drosophila melanogaster GN=Mlp60A PE=2 SV=1 PF00412//PF05502 LIM domain//Dynactin p62 family -- -- GO:0008270 zinc ion binding GO:0005869 dynactin complex KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.29352 BF_2 1100.07 24.47 2168 646682520 KDR02319.1 1568 2.1e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.51483e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.0e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00937//PF07714//PF00069 Coronavirus nucleocapsid protein//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.29354 BF_2 136.16 0.76 7780 270009468 EFA05916.1 2024 1.0e-223 hypothetical protein TcasGA2_TC008732 [Tribolium castaneum] 686207191 AP014521.1 40 2.06049e-08 Candidatus Tachikawaea gelatinosa DNA, complete genome K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q96HY7 1540 5.6e-169 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Homo sapiens GN=DHTKD1 PE=1 SV=2 PF00676//PF09412 Dehydrogenase E1 component//Endoribonuclease XendoU GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.29366 BF_2 21.24 0.84 1339 852805968 XP_012891429.1 277 6.6e-22 PREDICTED: zinc finger protein 33B-like [Dipodomys ordii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q32M78 277 2.7e-23 Zinc finger protein 699 OS=Homo sapiens GN=ZNF699 PE=1 SV=1 PF05443//PF13465//PF00096//PF02146//PF16622//PF13912 ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//Zinc finger, C2H2 type//Sir2 family//zinc-finger C2H2-type//C2H2-type zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0070403//GO:0003677//GO:0008270 metal ion binding//NAD+ binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.29368 BF_2 123.35 1.01 5381 642929988 XP_008196055.1 1781 1.1e-195 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K06095 MPDZ, MUPP1, Patj multiple PDZ domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K06095 Q9NB04 727 7.2e-75 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.29370 BF_2 18.73 0.34 2565 642917183 XP_008191154.1 360 3.0e-31 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05140 133 2.6e-06 Clathrin coat assembly protein AP180 OS=Rattus norvegicus GN=Snap91 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29371 BF_2 35.00 2.15 968 478256533 ENN76717.1 813 3.4e-84 hypothetical protein YQE_06782, partial [Dendroctonus ponderosae]>gi|546679994|gb|ERL90356.1| hypothetical protein D910_07705 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q14588 289 8.0e-25 Zinc finger protein 234 OS=Homo sapiens GN=ZNF234 PE=2 SV=3 PF06467//PF03067//PF00830//PF00096//PF05180//PF13912//PF02892//PF04810//PF00301//PF13465 MYM-type Zinc finger with FCS sequence motif//Chitin binding domain//Ribosomal L28 family//Zinc finger, C2H2 type//DNL zinc finger//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger//Rubredoxin//Zinc-finger double domain GO:0042254//GO:0006888//GO:0006886 ribosome biogenesis//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0005506//GO:0003735//GO:0008270//GO:0003677 metal ion binding//iron ion binding//structural constituent of ribosome//zinc ion binding//DNA binding GO:0005840//GO:0019028//GO:0030127 ribosome//viral capsid//COPII vesicle coat -- -- Cluster-8309.29372 BF_2 953.44 44.32 1187 91076410 XP_969526.1 1356 4.5e-147 PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002563|gb|EEZ99010.1| hypothetical protein TcasGA2_TC004878 [Tribolium castaneum] 731510745 XM_010600440.1 62 1.8074e-21 PREDICTED: Loxodonta africana aldose reductase-related protein 2-like (LOC100673621), mRNA K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15122 972 6.2e-104 Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.29376 BF_2 6342.16 88.94 3270 332375923 AEE63102.1 1088 1.5e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17711 PTCD2 pentatricopeptide repeat domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17711 Q3SZ55 339 4.3e-30 Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus GN=PTCD2 PE=2 SV=1 PF05049//PF11380//PF04750 Interferon-inducible GTPase (IIGP)//Stealth protein CR2, conserved region 2//FAR-17a/AIG1-like protein -- -- GO:0016772//GO:0005525 transferase activity, transferring phosphorus-containing groups//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.29377 BF_2 126.36 1.32 4287 91085875 XP_966911.1 1172 3.5e-125 PREDICTED: pentatricopeptide repeat-containing protein 2, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ55 357 4.6e-32 Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus GN=PTCD2 PE=2 SV=1 PF04750//PF11380//PF05049 FAR-17a/AIG1-like protein//Stealth protein CR2, conserved region 2//Interferon-inducible GTPase (IIGP) -- -- GO:0005525//GO:0016772 GTP binding//transferase activity, transferring phosphorus-containing groups GO:0016021//GO:0016020 integral component of membrane//membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.29380 BF_2 18.72 0.39 2310 189239809 XP_970870.2 956 2.1e-100 PREDICTED: transmembrane protease serine 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 361 8.5e-33 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.29382 BF_2 1.00 5.48 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29383 BF_2 117.00 1.62 3315 546672912 ERL84628.1 663 2.8e-66 hypothetical protein D910_02056 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35416 300 1.4e-25 Paramyosin, short form OS=Drosophila melanogaster GN=Prm PE=2 SV=2 PF15745//PF12678 AP-1 complex-associated regulatory protein//RING-H2 zinc finger GO:1900025//GO:2000146//GO:0048203//GO:0034315 negative regulation of substrate adhesion-dependent cell spreading//negative regulation of cell motility//vesicle targeting, trans-Golgi to endosome//regulation of Arp2/3 complex-mediated actin nucleation GO:0008270//GO:0035650 zinc ion binding//AP-1 adaptor complex binding -- -- -- -- Cluster-8309.29384 BF_2 35.71 0.61 2745 91087957 XP_972849.1 2550 3.6e-285 PREDICTED: eukaryotic translation initiation factor 3 subunit B [Tribolium castaneum]>gi|270011918|gb|EFA08366.1| hypothetical protein TcasGA2_TC006009 [Tribolium castaneum] 759033163 XM_011349720.1 153 1.10066e-71 PREDICTED: Cerapachys biroi eukaryotic translation initiation factor 3 subunit B (LOC105285460), mRNA K03253 EIF3B translation initiation factor 3 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K03253 Q1HDZ5 2003 4.0e-223 Eukaryotic translation initiation factor 3 subunit B OS=Bombyx mori GN=eIF3-S9 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0000166//GO:0003676//GO:0003743 nucleotide binding//nucleic acid binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG2314 Translation initiation factor 3, subunit b (eIF-3b) Cluster-8309.29385 BF_2 54.45 0.44 5512 189236448 XP_973457.2 1718 2.2e-188 PREDICTED: protein tumorous imaginal discs, mitochondrial isoform X2 [Tribolium castaneum]>gi|270005934|gb|EFA02382.1| hypothetical protein TcasGA2_TC008059 [Tribolium castaneum] 642919851 XM_968364.3 179 7.83405e-86 PREDICTED: Tribolium castaneum protein tumorous imaginal discs, mitochondrial (LOC662253), transcript variant X2, mRNA K09504 DNAJA3 DnaJ homolog subfamily A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09504 Q24331 1392 5.7e-152 Protein tumorous imaginal discs, mitochondrial OS=Drosophila virilis GN=l(2)tid PE=2 SV=1 PF00684 DnaJ central domain GO:0006457//GO:0009408//GO:0006260 protein folding//response to heat//DNA replication GO:0005524//GO:0031072//GO:0051082//GO:0046872 ATP binding//heat shock protein binding//unfolded protein binding//metal ion binding GO:0005737 cytoplasm KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.29386 BF_2 1355.64 18.78 3307 91087179 XP_975411.1 869 3.7e-90 PREDICTED: flavin reductase (NADPH) [Tribolium castaneum]>gi|270010563|gb|EFA07011.1| hypothetical protein TcasGA2_TC009981 [Tribolium castaneum] -- -- -- -- -- K05901 BLVRB biliverdin reductase / flavin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K05901 P30043 441 6.5e-42 Flavin reductase (NADPH) OS=Homo sapiens GN=BLVRB PE=1 SV=3 PF13508//PF00583//PF13302//PF13673//PF01370 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//NAD dependent epimerase/dehydratase family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0000166//GO:0003824//GO:0050662 N-acetyltransferase activity//nucleotide binding//catalytic activity//coenzyme binding -- -- KOG3397 Acetyltransferases Cluster-8309.29389 BF_2 148.20 1.36 4846 91090806 XP_970749.1 3178 0.0e+00 PREDICTED: ubiquitin-protein ligase E3B [Tribolium castaneum]>gi|270013259|gb|EFA09707.1| hypothetical protein TcasGA2_TC011840 [Tribolium castaneum] 642935863 XM_965656.2 317 1.33012e-162 PREDICTED: Tribolium castaneum ubiquitin-protein ligase E3B (LOC659339), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q08CZ0 1607 5.9e-177 Ubiquitin-protein ligase E3B OS=Xenopus tropicalis GN=ube3b PE=2 SV=1 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.29390 BF_2 25.26 0.47 2548 91091700 XP_972740.1 2485 1.2e-277 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 F4HTM3 1377 1.4e-150 Mannosyl-oligosaccharide glucosidase GCS1 OS=Arabidopsis thaliana GN=GCS1 PE=1 SV=1 -- -- GO:0009311 oligosaccharide metabolic process GO:0004573 mannosyl-oligosaccharide glucosidase activity -- -- KOG2161 Glucosidase I Cluster-8309.29393 BF_2 309.25 10.66 1501 642917757 XP_008191356.1 636 1.7e-63 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 92 4.83979e-38 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.29394 BF_2 290.00 11.40 1351 642934996 XP_008199899.1 498 1.6e-47 PREDICTED: pre-mRNA-splicing ATP-dependent RNA helicase PRP28-like [Tribolium castaneum]>gi|642934998|ref|XP_008199900.1| PREDICTED: pre-mRNA-splicing ATP-dependent RNA helicase PRP28-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29395 BF_2 137.00 10.70 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29396 BF_2 43.45 0.42 4566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14634 zinc-RING finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.29397 BF_2 8.00 0.63 822 121485025 ABM54577.1 979 1.6e-103 Hsp90 [Penaeus monodon] 675888733 XM_009031621.1 191 2.40746e-93 Helobdella robusta hypothetical protein partial mRNA K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 P30946 939 2.9e-100 Heat shock protein HSP 90-alpha OS=Oryctolagus cuniculus GN=HSP90AA1 PE=1 SV=2 PF00183 Hsp90 protein GO:0006950//GO:0006457 response to stress//protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.294 BF_2 11.00 0.56 1115 556769596 XP_005980003.1 267 7.9e-21 PREDICTED: NAD(P)H-quinone oxidoreductase subunit K, chloroplastic-like [Pantholops hodgsonii] 761231856 KM881642.1 1109 0 Oryza longistaminata isolate 81953 chloroplast, complete genome K03940 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03940 P0C340 876 7.9e-93 NAD(P)H-quinone oxidoreductase subunit J, chloroplastic OS=Oryza sativa subsp. japonica GN=ndhJ PE=3 SV=1 PF01058//PF00329 NADH ubiquinone oxidoreductase, 20 Kd subunit//Respiratory-chain NADH dehydrogenase, 30 Kd subunit GO:0006744//GO:0006120//GO:0006814//GO:0055114//GO:0015992 ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//oxidation-reduction process//proton transport GO:0051536//GO:0008137 iron-sulfur cluster binding//NADH dehydrogenase (ubiquinone) activity -- -- KOG1713 NADH-ubiquinone oxidoreductase, NDUFS3/30 kDa subunit Cluster-8309.29400 BF_2 18.00 0.43 2040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06058 Dcp1-like decapping family GO:0043085//GO:0000290 positive regulation of catalytic activity//deadenylation-dependent decapping of nuclear-transcribed mRNA GO:0008047 enzyme activator activity -- -- -- -- Cluster-8309.29401 BF_2 2407.58 19.46 5463 189242442 XP_001807060.1 1958 3.2e-216 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- K19599 DOME cytokine receptor domeless http://www.genome.jp/dbget-bin/www_bget?ko:K19599 Q9VWE0 500 1.5e-48 Cytokine receptor OS=Drosophila melanogaster GN=dome PE=1 SV=1 PF00041//PF16794 Fibronectin type III domain//Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29402 BF_2 1314.91 378.29 432 91094205 XP_971661.1 161 6.0e-09 PREDICTED: cytochrome c oxidase subunit 7A1, mitochondrial [Tribolium castaneum]>gi|270011120|gb|EFA07568.1| hypothetical protein TcasGA2_TC015888 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VHS2 122 8.2e-06 Probable cytochrome c oxidase subunit 7A, mitochondrial OS=Drosophila melanogaster GN=CG9603 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29403 BF_2 35.00 0.65 2523 768411468 XP_011563896.1 145 2.5e-06 PREDICTED: mucin-6-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- P0DM55 132 3.3e-06 Venom peptide SjAPI OS=Scorpiops jendeki PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29404 BF_2 171.00 8.33 1146 91080179 XP_970720.1 1130 6.9e-121 PREDICTED: inhibitor of growth protein 1 [Tribolium castaneum]>gi|270005646|gb|EFA02094.1| hypothetical protein TcasGA2_TC007731 [Tribolium castaneum] -- -- -- -- -- K19197 ING1 inhibitor of growth protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19197 Q9QXV3 463 6.3e-45 Inhibitor of growth protein 1 OS=Mus musculus GN=Ing1 PE=2 SV=1 PF00628 PHD-finger -- -- GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.29408 BF_2 479.58 11.43 2043 332376384 AEE63332.1 290 3.1e-23 unknown [Dendroctonus ponderosae]>gi|478255402|gb|ENN75624.1| hypothetical protein YQE_07802, partial [Dendroctonus ponderosae]>gi|546675094|gb|ERL86344.1| hypothetical protein D910_03752 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00307//PF05497 Calponin homology (CH) domain//Destabilase GO:0005975 carbohydrate metabolic process GO:0005515//GO:0003796 protein binding//lysozyme activity -- -- -- -- Cluster-8309.29409 BF_2 1.00 0.37 400 -- -- -- -- -- 571553487 XM_006564465.1 153 1.49251e-72 PREDICTED: Apis mellifera uncharacterized LOC102654086 (LOC102654086), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29411 BF_2 438.93 11.06 1947 642920590 XP_008192477.1 784 1.6e-80 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 642 1.9e-65 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083//PF00326//PF01738//PF01083 Partial alpha/beta-hydrolase lipase region//Prolyl oligopeptidase family//Dienelactone hydrolase family//Cutinase GO:0006629//GO:0006508//GO:0008152 lipid metabolic process//proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.29412 BF_2 188.00 7.17 1384 91081317 XP_969842.1 1282 2.0e-138 PREDICTED: KRR1 small subunit processome component homolog [Tribolium castaneum] 769851452 XM_011638863.1 153 5.48266e-72 PREDICTED: Pogonomyrmex barbatus KRR1 small subunit processome component homolog (LOC105427209), mRNA K06961 KRR1 ribosomal RNA assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K06961 B4N0P7 1070 3.1e-115 KRR1 small subunit processome component homolog OS=Drosophila willistoni GN=dbe PE=3 SV=1 PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2874 rRNA processing protein Cluster-8309.29413 BF_2 485.02 4.66 4640 573884393 XP_006630279.1 261 1.6e-19 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 729-like [Lepisosteus oculatus] 642937236 XM_008200529.1 145 5.23786e-67 PREDICTED: Tribolium castaneum zinc finger protein 1 (LOC100141776), transcript variant X4, mRNA K09299 ZEB1_2 zinc finger homeobox protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K09299 Q03936 256 2.6e-20 Zinc finger protein 92 OS=Homo sapiens GN=ZNF92 PE=2 SV=2 PF00046//PF00096//PF13465//PF01155//PF05920//PF13912 Homeobox domain//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Homeobox KN domain//C2H2-type zinc finger GO:0006355//GO:0006464 regulation of transcription, DNA-templated//cellular protein modification process GO:0003677//GO:0046872//GO:0016151 DNA binding//metal ion binding//nickel cation binding -- -- -- -- Cluster-8309.29417 BF_2 17.00 1.70 705 478255334 ENN75560.1 258 5.6e-20 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29418 BF_2 778.00 49.55 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29419 BF_2 220.64 5.61 1932 478259274 ENN79176.1 258 1.5e-19 hypothetical protein YQE_04360, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.29424 BF_2 12.00 0.68 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29428 BF_2 33.39 0.41 3661 642936574 XP_008198491.1 1031 6.7e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 3.2e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF10590//PF01243//PF12766//PF02252//PF05175//PF02251 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Proteasome activator pa28 beta subunit//Methyltransferase small domain//Proteasome activator pa28 alpha subunit GO:0008615//GO:0055114 pyridoxine biosynthetic process//oxidation-reduction process GO:0008168//GO:0010181//GO:0004733//GO:0016638 methyltransferase activity//FMN binding//pyridoxamine-phosphate oxidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.29429 BF_2 405.31 5.09 3619 642936574 XP_008198491.1 1031 6.6e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 3.1e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF10590//PF02252//PF12766//PF01243//PF05175//PF02251 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Proteasome activator pa28 beta subunit//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Methyltransferase small domain//Proteasome activator pa28 alpha subunit GO:0008615//GO:0055114 pyridoxine biosynthetic process//oxidation-reduction process GO:0010181//GO:0008168//GO:0004733//GO:0016638 FMN binding//methyltransferase activity//pyridoxamine-phosphate oxidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.29430 BF_2 38.00 2.42 945 72008176 XP_780713.1 1033 1.0e-109 PREDICTED: cathepsin L1 [Strongylocentrotus purpuratus]>gi|780117232|ref|XP_011677394.1| PREDICTED: cathepsin L1 [Strongylocentrotus purpuratus] 391328504 XM_003738681.1 74 3.05135e-28 PREDICTED: Metaseiulus occidentalis cathepsin L-like (LOC100898915), mRNA K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 P25975 818 3.5e-86 Cathepsin L1 OS=Bos taurus GN=CTSL PE=1 SV=3 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.29432 BF_2 44.99 1.03 2115 642914509 XP_008201706.1 571 8.4e-56 PREDICTED: transcriptional enhancer factor TEF-1 isoform X1 [Tribolium castaneum] 768436108 XM_011561220.1 138 1.84288e-63 PREDICTED: Plutella xylostella protein scalloped (LOC105390007), transcript variant X4, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P30052 502 3.5e-49 Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1 PF01285//PF00424 TEA/ATTS domain family//REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005634//GO:0005667 host cell nucleus//nucleus//transcription factor complex KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.29433 BF_2 125.48 2.36 2513 642919790 XP_008192068.1 687 3.6e-69 PREDICTED: uncharacterized protein LOC661416 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12162 UFM1 ubiquitin-fold modifier 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12162 Q7PXE2 221 1.6e-16 Ubiquitin-fold modifier 1 OS=Anopheles gambiae GN=AGAP001364 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3483 Uncharacterized conserved protein Cluster-8309.29434 BF_2 781.09 8.74 4026 820805540 AKG92761.1 526 2.7e-50 mnt2 [Leptinotarsa decemlineata] 642912790 XM_008203032.1 213 7.17794e-105 PREDICTED: Tribolium castaneum max-interacting protein 1-like (LOC100142502), mRNA K09114 MXD, MAD MAX dimerization protein http://www.genome.jp/dbget-bin/www_bget?ko:K09114 P50538 270 5.3e-22 Max dimerization protein 1 OS=Mus musculus GN=Mxd1 PE=1 SV=2 PF00010//PF07448 Helix-loop-helix DNA-binding domain//Secreted phosphoprotein 24 (Spp-24) GO:0046849 bone remodeling GO:0046983 protein dimerization activity GO:0005576 extracellular region KOG2483 Upstream transcription factor 2/L-myc-2 protein Cluster-8309.29436 BF_2 17.00 0.34 2350 512921334 XP_004929851.1 1800 2.9e-198 PREDICTED: probable citrate synthase 2, mitochondrial [Bombyx mori] 729734967 XM_010565183.1 411 0 PREDICTED: Haliaeetus leucocephalus citrate synthase (CS), mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q17GM7 1795 4.5e-199 Probable citrate synthase 1, mitochondrial OS=Aedes aegypti GN=AAEL002956 PE=3 SV=1 PF00285 Citrate synthase -- -- GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer -- -- KOG2617 Citrate synthase Cluster-8309.29438 BF_2 364.00 7.68 2269 224922687 BAH28836.1 2193 7.5e-244 elongation factor 1-alpha [Marsupenaeus japonicus] 393395825 JQ824130.1 1499 0 Scylla paramamosain elongation factor 1A mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P29520 1911 1.5e-212 Elongation factor 1-alpha OS=Bombyx mori PE=2 SV=1 PF04670//PF01926//PF03144 Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.29440 BF_2 838.60 15.88 2496 546676129 ERL87196.1 501 1.3e-47 hypothetical protein D910_04595 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.29442 BF_2 329.00 3.36 4383 642937102 XP_008198692.1 879 3.4e-91 PREDICTED: uncharacterized protein LOC659902 [Tribolium castaneum]>gi|642937104|ref|XP_008198693.1| PREDICTED: uncharacterized protein LOC659902 [Tribolium castaneum]>gi|270000885|gb|EEZ97332.1| hypothetical protein TcasGA2_TC011144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DIJ5 210 5.2e-15 High mobility group protein 20A OS=Xenopus tropicalis GN=hmg20a PE=2 SV=1 PF09726//PF00628//PF04111//PF06220 Transmembrane protein//PHD-finger//Autophagy protein Apg6//U1 zinc finger GO:0006914 autophagy GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.29446 BF_2 93.89 2.85 1666 478255527 ENN75744.1 1324 3.2e-143 hypothetical protein YQE_07704, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29449 BF_2 5.07 0.47 742 530233677 NP_001268819.1 222 8.7e-16 lipase 3-like precursor [Bombyx mori]>gi|511636164|gb|AGN90923.1| acid lipase-2 [Bombyx mori] -- -- -- -- -- K19406 LIPM lipase-like abhydrolase domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K19406 O46108 145 3.0e-08 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF02129 X-Pro dipeptidyl-peptidase (S15 family) -- -- GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.29450 BF_2 339.15 1.86 7920 91091444 XP_972566.1 1855 4.1e-204 PREDICTED: succinate-semialdehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270000977|gb|EEZ97424.1| hypothetical protein TcasGA2_TC011254 [Tribolium castaneum] -- -- -- -- -- K00139 ALDH5A1 succinate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00139 Q3MSM3 1320 1.8e-143 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Hylobates lar GN=ALDH5A1 PE=2 SV=1 PF00171//PF00013 Aldehyde dehydrogenase family//KH domain GO:0006570//GO:0055114//GO:0009450//GO:0008152 tyrosine metabolic process//oxidation-reduction process//gamma-aminobutyric acid catabolic process//metabolic process GO:0016491//GO:0009013//GO:0003723 oxidoreductase activity//succinate-semialdehyde dehydrogenase [NAD(P)+] activity//RNA binding -- -- KOG2451 Aldehyde dehydrogenase Cluster-8309.29452 BF_2 400.41 11.63 1728 91084999 XP_973197.1 1693 5.4e-186 PREDICTED: TBC1 domain family member 10A [Tribolium castaneum]>gi|270009019|gb|EFA05467.1| hypothetical protein TcasGA2_TC015650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHL3 888 4.9e-94 TBC1 domain family member 10B OS=Mus musculus GN=Tbc1d10b PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634//GO:0005622 nucleus//intracellular KOG2221 PDZ-domain interacting protein EPI64, contains TBC domain Cluster-8309.29453 BF_2 25.40 0.36 3213 642917564 XP_008191258.1 2410 7.3e-269 PREDICTED: NF-X1-type zinc finger protein NFXL1 [Tribolium castaneum] -- -- -- -- -- K15683 NFXL1, OZFP NF-X1-type zinc finger protein NFXL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15683 Q6ZNB6 1650 4.0e-182 NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens GN=NFXL1 PE=1 SV=2 PF08771//PF01422 Rapamycin binding domain//NF-X1 type zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008144//GO:0008270 transcription factor activity, sequence-specific DNA binding//drug binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.29455 BF_2 1569.31 35.95 2113 91078976 XP_974454.1 2314 6.5e-258 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 1006 1.3e-107 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4683 Uncharacterized conserved protein Cluster-8309.29456 BF_2 12.50 1.33 679 91078976 XP_974454.1 619 7.4e-62 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- K10532 HGSNAT heparan-alpha-glucosaminide N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10532 Q3UDW8 339 8.9e-31 Heparan-alpha-glucosaminide N-acetyltransferase OS=Mus musculus GN=Hgsnat PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4683 Uncharacterized conserved protein Cluster-8309.29457 BF_2 19.47 0.37 2465 642911299 XP_008199361.1 709 9.8e-72 PREDICTED: forkhead box protein P1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29458 BF_2 1710.96 45.68 1854 91083699 XP_969478.1 1354 1.2e-146 PREDICTED: periostin [Tribolium castaneum]>gi|270007879|gb|EFA04327.1| hypothetical protein TcasGA2_TC014621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O11780 130 4.2e-06 Transforming growth factor-beta-induced protein ig-h3 OS=Sus scrofa GN=TGFBI PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29460 BF_2 83.56 2.45 1712 642938573 XP_969296.2 662 1.9e-66 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum]>gi|642938575|ref|XP_008199847.1| PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 469 1.9e-45 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.29464 BF_2 55.50 0.97 2675 531447909 AGT57849.1 1450 1.3e-157 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 913 9.7e-97 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.29465 BF_2 390.68 5.64 3185 531447909 AGT57849.1 1618 5.0e-177 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 1015 1.7e-108 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.29467 BF_2 71.00 4.94 888 642923631 XP_008193582.1 1061 5.4e-113 PREDICTED: aromatic-L-amino-acid decarboxylase-like [Tribolium castaneum]>gi|270006966|gb|EFA03414.1| hypothetical protein TcasGA2_TC013401 [Tribolium castaneum] 158451428 EU032808.1 73 1.02879e-27 Erythromeris flexilineata voucher Eflex putative dopa decarboxylase protein mRNA, partial cds K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 O96571 808 4.8e-85 Aromatic-L-amino-acid decarboxylase (Fragment) OS=Drosophila lebanonensis GN=Ddc PE=3 SV=1 PF05889//PF00155//PF00282//PF01212 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Aminotransferase class I and II//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase GO:0019752//GO:0009058//GO:0006520 carboxylic acid metabolic process//biosynthetic process//cellular amino acid metabolic process GO:0016831//GO:0016740//GO:0016829//GO:0030170 carboxy-lyase activity//transferase activity//lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.29468 BF_2 117.83 9.86 787 478256140 ENN76339.1 720 1.7e-73 hypothetical protein YQE_07302, partial [Dendroctonus ponderosae] -- -- -- -- -- K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P18486 564 8.3e-57 Alpha-methyldopa hypersensitive protein OS=Drosophila melanogaster GN=amd PE=2 SV=2 PF00282 Pyridoxal-dependent decarboxylase conserved domain GO:0019752 carboxylic acid metabolic process GO:0016831//GO:0030170 carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.29471 BF_2 623.46 3.80 7147 642929299 XP_008195778.1 9649 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 6488 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF00223//PF10152//PF00647//PF08040//PF00514 Photosystem I psaA/psaB protein//Predicted coiled-coil domain-containing protein (DUF2360)//Elongation factor 1 gamma, conserved domain//MNLL subunit//Armadillo/beta-catenin-like repeat GO:0006414//GO:0015979//GO:0006448//GO:0006118 translational elongation//photosynthesis//regulation of translational elongation//obsolete electron transport GO:0005515//GO:0003954//GO:0003746 protein binding//NADH dehydrogenase activity//translation elongation factor activity GO:0016021//GO:0009522//GO:0005840//GO:0071203//GO:0009579//GO:0005739 integral component of membrane//photosystem I//ribosome//WASH complex//thylakoid//mitochondrion KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.29474 BF_2 42.00 2.13 1113 241671010 XP_002399960.1 527 5.6e-51 60S ribosomal protein L23, putative [Ixodes scapularis]>gi|215506218|gb|EEC15712.1| 60S ribosomal protein L23, putative [Ixodes scapularis] 821485126 XM_003770029.2 91 1.28159e-37 PREDICTED: Sarcophilus harrisii ribosomal protein L23a (RPL23A), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 495 1.2e-48 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0000166 structural constituent of ribosome//nucleotide binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.29475 BF_2 19.00 73.25 261 642938945 XP_008200098.1 272 4.9e-22 PREDICTED: probable cytochrome P450 6a23, partial [Tribolium castaneum]>gi|270016185|gb|EFA12633.1| cytochrome P450 6BK5, partial [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 213 1.4e-16 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0046872//GO:0005506//GO:0016491//GO:0016705 heme binding//metal ion binding//iron ion binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.29477 BF_2 27.77 0.48 2721 189240236 XP_001811057.1 1062 1.3e-112 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 55 3.27859e-17 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q7ZYD5 739 1.5e-76 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Xenopus laevis GN=slc25a25 PE=2 SV=1 PF03832 WSK motif GO:0007165//GO:0006605 signal transduction//protein targeting -- -- -- -- KOG0036 Predicted mitochondrial carrier protein Cluster-8309.29479 BF_2 451.52 7.25 2892 91076992 XP_975474.1 1215 2.4e-130 PREDICTED: ras-like protein 3 [Tribolium castaneum]>gi|270001761|gb|EEZ98208.1| hypothetical protein TcasGA2_TC000640 [Tribolium castaneum] 195387773 XM_002052531.1 54 1.25429e-16 Drosophila virilis GJ17614 (Dvir\GJ17614), mRNA K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 F1NHE9 770 4.0e-80 ATP-sensitive inward rectifier potassium channel 12 OS=Gallus gallus GN=KCNJ12 PE=1 SV=1 PF08477//PF03193//PF01926//PF00503//PF00025//PF00071//PF01007 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//G-protein alpha subunit//ADP-ribosylation factor family//Ras family//Inward rectifier potassium channel GO:0007264//GO:0007186//GO:0006184//GO:0006813//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//obsolete GTP catabolic process//potassium ion transport//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0005242//GO:0003924//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//inward rectifier potassium channel activity//GTPase activity//G-protein beta/gamma-subunit complex binding GO:0008076//GO:0016020//GO:0016021 voltage-gated potassium channel complex//membrane//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.29481 BF_2 129.98 3.40 1888 91091366 XP_972690.1 965 1.6e-101 PREDICTED: tRNA methyltransferase 10 homolog A [Tribolium castaneum]>gi|270014152|gb|EFA10600.1| hypothetical protein TcasGA2_TC012861 [Tribolium castaneum] -- -- -- -- -- K15445 TRMT10A, TRM10, RG9MTD2 tRNA (guanine9-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15445 Q8TBZ6 466 4.6e-45 tRNA methyltransferase 10 homolog A OS=Homo sapiens GN=TRMT10A PE=1 SV=1 -- -- GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2967 Uncharacterized conserved protein Cluster-8309.29483 BF_2 586.16 3.39 7516 642939434 XP_008200389.1 4154 0.0e+00 PREDICTED: pumilio homolog 2 isoform X2 [Tribolium castaneum] 642939433 XM_008202167.1 727 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806//PF02422 CPL (NUC119) domain//Pumilio-family RNA binding repeat//Keratin -- -- GO:0003723//GO:0005200 RNA binding//structural constituent of cytoskeleton GO:0005882//GO:0005856 intermediate filament//cytoskeleton KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.29484 BF_2 101.00 23.46 467 16226511 AAL16187.1 447 4.4e-42 larval cuticle protein precursor [Apriona germari] 16226510 AF428097.1 245 1.27123e-123 Apriona germari larval cuticle protein precursor (LCP10.7) mRNA, complete cds -- -- -- -- P45589 303 9.1e-27 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF13545//PF00379 Crp-like helix-turn-helix domain//Insect cuticle protein GO:0006355 regulation of transcription, DNA-templated GO:0042302//GO:0003677 structural constituent of cuticle//DNA binding -- -- -- -- Cluster-8309.29485 BF_2 20.00 0.54 1850 749745308 XP_011155190.1 179 2.1e-10 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29486 BF_2 95.80 2.17 2138 642921732 XP_008199304.1 436 3.9e-40 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 338 3.7e-30 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.29489 BF_2 67.00 3.51 1086 751461201 XP_011185396.1 178 1.6e-10 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- D2WKD9 130 2.4e-06 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29490 BF_2 689.73 33.21 1156 642926052 XP_970129.2 670 1.5e-67 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 222 5.6e-17 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29491 BF_2 7.87 0.95 635 270004614 EFA01062.1 289 1.3e-23 hypothetical protein TcasGA2_TC003980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76LL6 171 2.5e-11 FH1/FH2 domain-containing protein 3 OS=Mus musculus GN=Fhod3 PE=1 SV=1 PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family -- -- GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1925 Rac1 GTPase effector FHOS Cluster-8309.29492 BF_2 143.55 2.15 3084 478263298 ENN81679.1 668 7.0e-67 hypothetical protein YQE_01931, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF10717//PF03110 Chitin binding Peritrophin-A domain//Occlusion-derived virus envelope protein ODV-E18//SBP domain GO:0006030 chitin metabolic process GO:0008061//GO:0003677 chitin binding//DNA binding GO:0019031//GO:0005634//GO:0005576 viral envelope//nucleus//extracellular region -- -- Cluster-8309.29493 BF_2 43.97 3.30 845 270297218 NP_001161918.1 687 1.2e-69 cuticular protein analogous to peritrophins 1-H precursor [Tribolium castaneum]>gi|642929138|ref|XP_008195708.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|642929140|ref|XP_008195709.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|268309014|gb|ACY95473.1| cuticular protein analogous to peritrophins 1-H [Tribolium castaneum]>gi|270010495|gb|EFA06943.1| hypothetical protein TcasGA2_TC009894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.29497 BF_2 20.71 0.36 2668 332376210 AEE63245.1 1392 6.7e-151 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XJP1 724 8.0e-75 Protein TSSC1 OS=Danio rerio GN=tssc1 PE=2 SV=1 PF03121//PF00400//PF01215 Herpesviridae UL52/UL70 DNA primase//WD domain, G-beta repeat//Cytochrome c oxidase subunit Vb GO:0015992//GO:0006269//GO:0006260//GO:0006123//GO:0006351 proton transport//DNA replication, synthesis of RNA primer//DNA replication//mitochondrial electron transport, cytochrome c to oxygen//transcription, DNA-templated GO:0004129//GO:0005515//GO:0003896 cytochrome-c oxidase activity//protein binding//DNA primase activity GO:0005730//GO:0005740//GO:0045277//GO:0005657 nucleolus//mitochondrial envelope//respiratory chain complex IV//replication fork KOG1007 WD repeat protein TSSC1, WD repeat superfamily Cluster-8309.29498 BF_2 666.81 12.34 2547 332376210 AEE63245.1 1539 5.8e-168 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XJP1 844 9.2e-89 Protein TSSC1 OS=Danio rerio GN=tssc1 PE=2 SV=1 PF00400//PF01215 WD domain, G-beta repeat//Cytochrome c oxidase subunit Vb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0005515 cytochrome-c oxidase activity//protein binding GO:0045277//GO:0005740 respiratory chain complex IV//mitochondrial envelope KOG1007 WD repeat protein TSSC1, WD repeat superfamily Cluster-8309.29500 BF_2 9.00 0.88 713 642931274 XP_008196509.1 326 7.3e-28 PREDICTED: myosin heavy chain, muscle isoform X3 [Tribolium castaneum] 755853805 XM_011297467.1 128 2.17976e-58 PREDICTED: Musca domestica myosin heavy chain, muscle (LOC101893508), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 309 2.8e-27 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0161 Myosin class II heavy chain Cluster-8309.29502 BF_2 927.70 9.20 4506 642916693 XP_008192186.1 4445 0.0e+00 PREDICTED: membrane-bound transcription factor site-1 protease isoform X2 [Tribolium castaneum] 768954933 XM_003976835.2 102 4.07281e-43 PREDICTED: Takifugu rubripes membrane-bound transcription factor site-1 protease-like (LOC101078346), partial mRNA K08653 MBTPS1 membrane-bound transcription factor site-1 protease http://www.genome.jp/dbget-bin/www_bget?ko:K08653 Q9Z2A8 3338 0.0e+00 Membrane-bound transcription factor site-1 protease OS=Cricetulus griseus GN=MBTPS1 PE=1 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.29504 BF_2 175.34 2.06 3853 189240839 XP_001812334.1 2667 1.4e-298 PREDICTED: SWI/SNF complex subunit SMARCC2 [Tribolium castaneum]>gi|270013718|gb|EFA10166.1| hypothetical protein TcasGA2_TC012356 [Tribolium castaneum] 585702584 XM_006897683.1 41 2.82503e-09 PREDICTED: Elephantulus edwardii SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), mRNA K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q92922 1625 3.8e-179 SWI/SNF complex subunit SMARCC1 OS=Homo sapiens GN=SMARCC1 PE=1 SV=3 PF04433 SWIRM domain -- -- GO:0005488//GO:0005515 binding//protein binding -- -- KOG1279 Chromatin remodeling factor subunit and related transcription factors Cluster-8309.29505 BF_2 82.82 0.89 4169 189239379 XP_971918.2 485 1.6e-45 PREDICTED: receptor expression-enhancing protein 5 [Tribolium castaneum]>gi|270009667|gb|EFA06115.1| hypothetical protein TcasGA2_TC008958 [Tribolium castaneum] 667676433 AE013599.5 78 8.26759e-30 Drosophila melanogaster chromosome 2R K17279 REEP5_6 receptor expression-enhancing protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K17279 Q9V6Y3 444 3.7e-42 Probable 28S ribosomal protein S16, mitochondrial OS=Drosophila melanogaster GN=mRpS16 PE=2 SV=1 PF00886 Ribosomal protein S16 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.29506 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29510 BF_2 6.26 0.86 593 189238225 XP_970862.2 257 6.1e-20 PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum]>gi|642925540|ref|XP_008194592.1| PREDICTED: nuclear autoantigenic sperm protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414 TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29511 BF_2 610.20 6.93 3972 546685279 ERL94806.1 3262 0.0e+00 hypothetical protein D910_12080 [Dendroctonus ponderosae] 815898007 XM_003485762.2 360 0 PREDICTED: Bombus impatiens cullin-4A (LOC100740815), mRNA K10609 CUL4 cullin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10609 A2A432 2575 2.7e-289 Cullin-4B OS=Mus musculus GN=Cul4b PE=1 SV=1 PF00888//PF07516 Cullin family//SecA Wing and Scaffold domain GO:0006511//GO:0017038 ubiquitin-dependent protein catabolic process//protein import GO:0031625 ubiquitin protein ligase binding GO:0016020 membrane KOG2166 Cullins Cluster-8309.29512 BF_2 27.85 0.48 2728 642932076 XP_008196848.1 1166 1.1e-124 PREDICTED: pre-mRNA-splicing regulator female-lethal(2)D [Tribolium castaneum]>gi|270011667|gb|EFA08115.1| hypothetical protein TcasGA2_TC005719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y091 702 2.9e-72 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila melanogaster GN=fl(2)d PE=1 SV=2 PF02932//PF05791//PF17098//PF03233//PF09298//PF07361//PF02050//PF09177 Neurotransmitter-gated ion-channel transmembrane region//Bacillus haemolytic enterotoxin (HBL)//Pre-mRNA-splicing regulator WTAP//Aphid transmission protein//Fumarylacetoacetase N-terminal//Cytochrome b562//Flagellar FliJ protein//Syntaxin 6, N-terminal GO:0006570//GO:0009405//GO:0042207//GO:0022900//GO:0006118//GO:0009072//GO:0071973//GO:0048193//GO:0019089//GO:0006935//GO:0006811//GO:0048024 tyrosine metabolic process//pathogenesis//styrene catabolic process//electron transport chain//obsolete electron transport//aromatic amino acid family metabolic process//bacterial-type flagellum-dependent cell motility//Golgi vesicle transport//transmission of virus//chemotaxis//ion transport//regulation of mRNA splicing, via spliceosome GO:0005506//GO:0020037//GO:0004334//GO:0009055//GO:0003774 iron ion binding//heme binding//fumarylacetoacetase activity//electron carrier activity//motor activity GO:0042597//GO:0009288//GO:0005634//GO:0016020 periplasmic space//bacterial-type flagellum//nucleus//membrane KOG2991 Splicing regulator Cluster-8309.29513 BF_2 144.57 2.00 3305 478257765 ENN77908.1 1133 9.0e-121 hypothetical protein YQE_05585, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y091 696 1.7e-71 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila melanogaster GN=fl(2)d PE=1 SV=2 PF17098//PF04977//PF05791//PF06156//PF01496//PF11744//PF06005//PF09177//PF04799 Pre-mRNA-splicing regulator WTAP//Septum formation initiator//Bacillus haemolytic enterotoxin (HBL)//Protein of unknown function (DUF972)//V-type ATPase 116kDa subunit family//Aluminium activated malate transporter//Protein of unknown function (DUF904)//Syntaxin 6, N-terminal//fzo-like conserved region GO:0015991//GO:0048193//GO:0015743//GO:0000917//GO:0043093//GO:0048024//GO:0008053//GO:0009405//GO:0007049//GO:0015992//GO:0006260 ATP hydrolysis coupled proton transport//Golgi vesicle transport//malate transport//barrier septum assembly//FtsZ-dependent cytokinesis//regulation of mRNA splicing, via spliceosome//mitochondrial fusion//pathogenesis//cell cycle//proton transport//DNA replication GO:0003924//GO:0015078 GTPase activity//hydrogen ion transmembrane transporter activity GO:0005634//GO:0033179//GO:0016020//GO:0005741//GO:0016021//GO:0005737 nucleus//proton-transporting V-type ATPase, V0 domain//membrane//mitochondrial outer membrane//integral component of membrane//cytoplasm KOG2991 Splicing regulator Cluster-8309.29514 BF_2 4086.32 163.29 1334 264667437 ACY71304.1 658 4.3e-66 ribosomal protein S17 [Chrysomela tremula] 780657916 XM_011693770.1 153 5.27945e-72 PREDICTED: Wasmannia auropunctata 40S ribosomal protein S17 (LOC105452559), mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q962R2 595 3.6e-60 40S ribosomal protein S17 OS=Spodoptera frugiperda GN=RpS17 PE=2 SV=3 PF02175//PF00833 Serpentine type 7TM GPCR chemoreceptor Srb//Ribosomal S17 GO:0007606//GO:0042254//GO:0007165//GO:0006412 sensory perception of chemical stimulus//ribosome biogenesis//signal transduction//translation GO:0003735//GO:0004888 structural constituent of ribosome//transmembrane signaling receptor activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG0187 40S ribosomal protein S17 Cluster-8309.29517 BF_2 8.89 0.36 1329 642927976 XP_008195469.1 559 1.3e-54 PREDICTED: leptin receptor gene-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3Y064 375 1.2e-34 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 PF07440//PF07155 Caerin 1 protein//ECF-type riboflavin transporter, S component -- -- -- -- GO:0016020//GO:0005576 membrane//extracellular region KOG2174 Leptin receptor gene-related protein Cluster-8309.29518 BF_2 965.58 9.41 4580 91094045 XP_968644.1 1387 4.4e-150 PREDICTED: RNA-binding protein 12 [Tribolium castaneum]>gi|270003124|gb|EEZ99571.1| hypothetical protein TcasGA2_TC001555 [Tribolium castaneum] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 Q9VHR6 650 5.2e-66 Autophagy-related protein 13 homolog OS=Drosophila melanogaster GN=Atg13 PE=1 SV=1 PF06459//PF00076//PF08777 Ryanodine Receptor TM 4-6//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219//GO:0003723//GO:0003676 ryanodine-sensitive calcium-release channel activity//RNA binding//nucleic acid binding GO:0016021//GO:0005622 integral component of membrane//intracellular KOG4307 RNA binding protein RBM12/SWAN Cluster-8309.29521 BF_2 50.74 5.60 666 642939867 XP_969882.2 715 5.3e-73 PREDICTED: alpha-aminoadipic semialdehyde dehydrogenase [Tribolium castaneum] -- -- -- -- -- K14085 ALDH7A1 aldehyde dehydrogenase family 7 member A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14085 P46562 537 9.6e-54 Putative aldehyde dehydrogenase family 7 member A1 homolog OS=Caenorhabditis elegans GN=alh-9 PE=3 SV=2 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2453 Aldehyde dehydrogenase Cluster-8309.29524 BF_2 259.00 53.11 491 642915198 XP_008190515.1 286 2.2e-23 PREDICTED: protein phosphatase 1 regulatory subunit 12B-like isoform X5 [Tribolium castaneum] 642915197 XM_008192293.1 159 8.60471e-76 PREDICTED: Tribolium castaneum protein phosphatase 1 regulatory subunit 12B-like (LOC659634), transcript variant X5, mRNA K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 O60237 160 3.7e-10 Protein phosphatase 1 regulatory subunit 12B OS=Homo sapiens GN=PPP1R12B PE=1 SV=2 PF04612//PF15898//PF03462//PF06495//PF06156//PF04111//PF02183//PF08912//PF05837//PF03938//PF03480//PF08172//PF16326//PF04977//PF05478//PF02662 Type II secretion system (T2SS), protein M//cGMP-dependent protein kinase interacting domain//PCRF domain//Fruit fly transformer protein//Protein of unknown function (DUF972)//Autophagy protein Apg6//Homeobox associated leucine zipper//Rho Binding//Centromere protein H (CENP-H)//Outer membrane protein (OmpH-like)//Bacterial extracellular solute-binding protein, family 7//CASP C terminal//ABC transporter C-terminal domain//Septum formation initiator//Prominin//Methyl-viologen-reducing hydrogenase, delta subunit GO:0006891//GO:0006397//GO:0015948//GO:0006449//GO:0051382//GO:0006810//GO:0006914//GO:0006260//GO:0006415//GO:0006355//GO:0006858//GO:0007049//GO:0055114//GO:0046660 intra-Golgi vesicle-mediated transport//mRNA processing//methanogenesis//regulation of translational termination//kinetochore assembly//transport//autophagy//DNA replication//translational termination//regulation of transcription, DNA-templated//extracellular transport//cell cycle//oxidation-reduction process//female sex differentiation GO:0003677//GO:0016149//GO:0017048//GO:0019901//GO:0043565//GO:0051082//GO:0003700 DNA binding//translation release factor activity, codon specific//Rho GTPase binding//protein kinase binding//sequence-specific DNA binding//unfolded protein binding//transcription factor activity, sequence-specific DNA binding GO:0030288//GO:0005634//GO:0005667//GO:0030173//GO:0000776//GO:0016021//GO:0005840//GO:0005737//GO:0018444 outer membrane-bounded periplasmic space//nucleus//transcription factor complex//integral component of Golgi membrane//kinetochore//integral component of membrane//ribosome//cytoplasm//translation release factor complex KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.29525 BF_2 307.00 43.85 580 665788819 XP_008560020.1 135 8.3e-06 PREDICTED: protein phosphatase 1 regulatory subunit 12A-like isoform X4 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29526 BF_2 281.78 1.71 7162 91087897 XP_970459.1 859 1.2e-88 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270012016|gb|EFA08464.1| hypothetical protein TcasGA2_TC006113 [Tribolium castaneum] 642930872 XM_965366.2 96 1.40481e-39 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 1.6e-16 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF05495//PF11808 CHY zinc finger//Domain of unknown function (DUF3329) GO:0016310 phosphorylation GO:0008270//GO:0004673 zinc ion binding//protein histidine kinase activity GO:0009365 protein histidine kinase complex -- -- Cluster-8309.29527 BF_2 239.41 5.15 2230 478258110 ENN78248.1 2252 1.1e-250 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] -- -- -- -- -- K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 Q6S9C8 1436 1.8e-157 Leukotriene A-4 hydrolase OS=Chinchilla lanigera GN=LTA4H PE=2 SV=3 PF09127//PF01433//PF01435 Leukotriene A4 hydrolase, C-terminal//Peptidase family M1//Peptidase family M48 GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0004222//GO:0008270//GO:0008237 metalloendopeptidase activity//zinc ion binding//metallopeptidase activity -- -- KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.29528 BF_2 220.59 4.18 2493 189233588 XP_969590.2 995 6.8e-105 PREDICTED: palmitoyl-protein thioesterase 1 [Tribolium castaneum]>gi|270014931|gb|EFA11379.1| hypothetical protein TcasGA2_TC011538 [Tribolium castaneum] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 O88531 733 6.7e-76 Palmitoyl-protein thioesterase 1 OS=Mus musculus GN=Ppt1 PE=2 SV=2 PF01674//PF02089 Lipase (class 2)//Palmitoyl protein thioesterase GO:0006464 cellular protein modification process GO:0098599//GO:0008474//GO:0016787 palmitoyl hydrolase activity//palmitoyl-(protein) hydrolase activity//hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.29529 BF_2 93.41 0.92 4512 478258110 ENN78248.1 2446 6.9e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 3.64182e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.6e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF09127//PF01433//PF01435//PF00400//PF08063 Leukotriene A4 hydrolase, C-terminal//Peptidase family M1//Peptidase family M48//WD domain, G-beta repeat//PADR1 (NUC008) domain GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008270//GO:0008237 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//zinc ion binding//metallopeptidase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.2953 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29534 BF_2 102.51 3.28 1595 642922837 XP_008193347.1 1287 6.0e-139 PREDICTED: isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like isoform X1 [Tribolium castaneum]>gi|270007569|gb|EFA04017.1| hypothetical protein TcasGA2_TC014166 [Tribolium castaneum] 642922838 XM_968977.2 264 1.25183e-133 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X2, mRNA K00030 IDH3 isocitrate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00030 P41565 732 5.6e-76 Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial OS=Rattus norvegicus GN=Idh3g PE=2 SV=2 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0055114//GO:0006099 oxidation-reduction process//tricarboxylic acid cycle GO:0000287//GO:0004449//GO:0016616//GO:0051287 magnesium ion binding//isocitrate dehydrogenase (NAD+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG0784 Isocitrate dehydrogenase, gamma subunit Cluster-8309.29536 BF_2 11.04 1.14 694 270008922 EFA05370.1 299 9.6e-25 hypothetical protein TcasGA2_TC015536 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 P61291 132 9.2e-07 Proteasome activator complex subunit 3 OS=Sus scrofa GN=PSME3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29541 BF_2 137.03 1.61 3839 642932262 XP_008197037.1 3943 0.0e+00 PREDICTED: exosome complex exonuclease RRP44 [Tribolium castaneum]>gi|270012315|gb|EFA08763.1| hypothetical protein TcasGA2_TC006450 [Tribolium castaneum] 642932261 XM_008198815.1 549 0 PREDICTED: Tribolium castaneum exosome complex exonuclease RRP44 (LOC655788), mRNA K12585 DIS3, RRP44 exosome complex exonuclease DIS3/RRP44 http://www.genome.jp/dbget-bin/www_bget?ko:K12585 Q9Y2L1 2571 7.7e-289 Exosome complex exonuclease RRP44 OS=Homo sapiens GN=DIS3 PE=1 SV=2 -- -- GO:0051252 regulation of RNA metabolic process GO:0003723//GO:0004540 RNA binding//ribonuclease activity -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.29542 BF_2 18.54 5.30 433 332374764 AEE62523.1 261 1.5e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06126 COQ6 ubiquinone biosynthesis monooxygenase Coq6 http://www.genome.jp/dbget-bin/www_bget?ko:K06126 Q6DF46 185 4.1e-13 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Xenopus tropicalis GN=coq6 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3855 Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis Cluster-8309.29544 BF_2 88.71 1.07 3745 859132811 AKO63319.1 3478 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2391 5.6e-268 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF00368//PF00487//PF02460 Hydroxymethylglutaryl-coenzyme A reductase//Fatty acid desaturase//Patched family GO:0007165//GO:0006629//GO:0006694//GO:0055114//GO:0015936 signal transduction//lipid metabolic process//steroid biosynthetic process//oxidation-reduction process//coenzyme A metabolic process GO:0050662//GO:0008158//GO:0004420 coenzyme binding//hedgehog receptor activity//hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0016020 membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.29545 BF_2 22.33 0.53 2058 642914174 XP_008201575.1 477 6.5e-45 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15182 Otospiralin GO:0007605 sensory perception of sound -- -- -- -- -- -- Cluster-8309.29546 BF_2 269.41 1.40 8345 642911905 XP_008199016.1 3231 0.0e+00 PREDICTED: protein pigeon isoform X1 [Tribolium castaneum] -- -- -- -- -- K01581 E4.1.1.17, ODC1, speC, speF ornithine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01581 Q24118 1736 1.1e-191 Protein pigeon OS=Drosophila melanogaster GN=pigeon PE=2 SV=2 PF03374//PF00278//PF15494//PF02784 Phage antirepressor protein KilAC domain//Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Scavenger receptor cysteine-rich domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain -- -- GO:0003824//GO:0003677 catalytic activity//DNA binding GO:0016020 membrane KOG0622 Ornithine decarboxylase Cluster-8309.29547 BF_2 1065.21 11.84 4050 642938314 XP_008192827.1 891 1.3e-92 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X7 [Tribolium castaneum] 642938313 XM_008194605.1 199 4.37685e-97 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X8, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 Q9VWW0 282 2.2e-23 Cyclic AMP response element-binding protein B OS=Drosophila melanogaster GN=CrebB PE=1 SV=1 PF02173//PF00170//PF07716//PF03131 pKID domain//bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700//GO:0005515 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.29550 BF_2 1427.32 11.11 5662 642934494 XP_008197688.1 6774 0.0e+00 PREDICTED: proteasome-associated protein ECM29 homolog [Tribolium castaneum] -- -- -- -- -- K11886 ECM29 proteasome component ECM29 http://www.genome.jp/dbget-bin/www_bget?ko:K11886 Q5VYK3 3099 0.0e+00 Proteasome-associated protein ECM29 homolog OS=Homo sapiens GN=ECM29 PE=1 SV=2 PF08064//PF02985 UME (NUC010) domain//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0005515 protein serine/threonine kinase activity//protein binding -- -- KOG0915 Uncharacterized conserved protein Cluster-8309.29553 BF_2 23.63 0.42 2647 91092388 XP_968476.1 2123 1.1e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.1394e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29557 BF_2 59.01 1.21 2334 478259929 ENN79731.1 755 4.3e-77 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 408 3.1e-38 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.29559 BF_2 197.26 2.39 3743 91090802 XP_970620.1 877 4.9e-91 PREDICTED: ran-binding protein 3 isoform X1 [Tribolium castaneum]>gi|270013975|gb|EFA10423.1| hypothetical protein TcasGA2_TC012664 [Tribolium castaneum] -- -- -- -- -- K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 Q5ZMQ9 522 3.0e-51 Peroxisomal targeting signal 1 receptor OS=Gallus gallus GN=PEX5 PE=2 SV=1 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG1125 TPR repeat-containing protein Cluster-8309.29564 BF_2 173.16 2.28 3466 478254798 ENN75034.1 1443 1.1e-156 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 167 2.29922e-79 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 980 2.1e-104 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.29565 BF_2 353.28 6.13 2697 383864945 XP_003707938.1 1685 7.2e-185 PREDICTED: guanine nucleotide-binding protein G(i) subunit alpha [Megachile rotundata] 766921600 XM_011507026.1 214 1.33099e-105 PREDICTED: Ceratosolen solmsi marchali guanine nucleotide-binding protein G(i) subunit alpha-like (LOC105368111), mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 P41776 1581 3.4e-174 Guanine nucleotide-binding protein G(i) subunit alpha OS=Homarus americanus PE=2 SV=2 PF00503//PF00025//PF04670//PF08477 G-protein alpha subunit//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0019001//GO:0004871//GO:0005525//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//GTP binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.29566 BF_2 2.00 0.50 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29571 BF_2 104.14 0.48 9291 91076206 XP_972459.1 2316 1.7e-257 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 5.18182e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 3.3e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF15182//PF00628//PF07649//PF13606//PF00130//PF13939//PF00023//PF15898//PF01300 Otospiralin//PHD-finger//C1-like domain//Ankyrin repeat//Phorbol esters/diacylglycerol binding domain (C1 domain)//Toxin TisB, type I toxin-antitoxin system//Ankyrin repeat//cGMP-dependent protein kinase interacting domain//Telomere recombination GO:0007605//GO:0009432//GO:0006820//GO:0022611//GO:0055114//GO:0035556 sensory perception of sound//SOS response//anion transport//dormancy process//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0019901//GO:0005253//GO:0047134//GO:0003725 protein binding//protein kinase binding//anion channel activity//protein-disulfide reductase activity//double-stranded RNA binding GO:0005887 integral component of plasma membrane KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.29574 BF_2 376.03 13.00 1497 91083613 XP_969708.1 722 1.8e-73 PREDICTED: calmodulin [Tribolium castaneum]>gi|270007842|gb|EFA04290.1| hypothetical protein TcasGA2_TC014581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T0E8 267 4.4e-22 Calmodulin-like protein 4 OS=Bos taurus GN=CALML4 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.29576 BF_2 429.33 1.92 9624 642911194 XP_008199555.1 11323 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X2 [Tribolium castaneum] 805816096 XM_012293285.1 501 0 PREDICTED: Megachile rotundata inositol 1,4,5-trisphosphate receptor (LOC100879087), transcript variant X4, mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 8649 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF00520//PF01365//PF02815 Ion transport protein//RIH domain//MIR domain GO:0070588//GO:0006811//GO:0006816//GO:0055085 calcium ion transmembrane transport//ion transport//calcium ion transport//transmembrane transport GO:0005216//GO:0005262 ion channel activity//calcium channel activity GO:0016020 membrane KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.29577 BF_2 181.44 1.37 5831 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29579 BF_2 132.00 2.48 2518 642918788 XP_008191584.1 2363 1.6e-263 PREDICTED: uncharacterized protein LOC660407 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61366 230 1.4e-17 Serine-enriched protein OS=Drosophila melanogaster GN=gprs PE=3 SV=3 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.29580 BF_2 17.00 1.17 895 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29581 BF_2 477.35 5.33 4032 817086017 XP_012265717.1 142 9.0e-06 PREDICTED: uncharacterized protein LOC105691660 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.29582 BF_2 95.00 12.62 602 762081924 XP_011422687.1 142 1.3e-06 PREDICTED: nidogen-2-like [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region -- -- Cluster-8309.29583 BF_2 248.35 1.38 7831 546684330 ERL94035.1 2717 4.5e-304 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R189 532 4.3e-52 Protein unc-13 homolog D OS=Rattus norvegicus GN=Unc13d PE=2 SV=1 PF00168//PF01688//PF08392 C2 domain//Alphaherpesvirus glycoprotein I//FAE1/Type III polyketide synthase-like protein GO:0006633 fatty acid biosynthetic process GO:0016747//GO:0005515 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding GO:0043657//GO:0016020 host cell//membrane KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.29585 BF_2 59.04 0.68 3929 91091444 XP_972566.1 1578 2.7e-172 PREDICTED: succinate-semialdehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270000977|gb|EEZ97424.1| hypothetical protein TcasGA2_TC011254 [Tribolium castaneum] -- -- -- -- -- K00139 ALDH5A1 succinate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00139 Q3MSM3 1099 3.8e-118 Succinate-semialdehyde dehydrogenase, mitochondrial OS=Hylobates lar GN=ALDH5A1 PE=2 SV=1 PF00171//PF00013 Aldehyde dehydrogenase family//KH domain GO:0009450//GO:0008152//GO:0006570//GO:0055114 gamma-aminobutyric acid catabolic process//metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0009013//GO:0003723//GO:0016491 succinate-semialdehyde dehydrogenase [NAD(P)+] activity//RNA binding//oxidoreductase activity -- -- KOG2451 Aldehyde dehydrogenase Cluster-8309.29587 BF_2 825.86 3.76 9470 546684330 ERL94035.1 3979 0.0e+00 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O94812 756 5.5e-78 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF02947//PF00168//PF08392//PF01688 flt3 ligand//C2 domain//FAE1/Type III polyketide synthase-like protein//Alphaherpesvirus glycoprotein I GO:0007165//GO:0006633 signal transduction//fatty acid biosynthetic process GO:0005125//GO:0016747//GO:0005515 cytokine activity//transferase activity, transferring acyl groups other than amino-acyl groups//protein binding GO:0016020//GO:0043657 membrane//host cell KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.29588 BF_2 2.00 0.92 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29589 BF_2 87.94 0.43 8933 546684330 ERL94035.1 3510 0.0e+00 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O94812 595 2.4e-59 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF01688//PF08392//PF00168 Alphaherpesvirus glycoprotein I//FAE1/Type III polyketide synthase-like protein//C2 domain GO:0006633 fatty acid biosynthetic process GO:0005515//GO:0016747 protein binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0043657//GO:0016020 host cell//membrane KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.29591 BF_2 9.11 0.50 1050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29592 BF_2 21.69 2.26 688 741829858 AJA91073.1 505 1.2e-48 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 407 1.2e-38 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.29594 BF_2 443.35 6.49 3145 91088147 XP_971356.1 1233 2.2e-132 PREDICTED: platelet-activating factor acetylhydrolase [Tribolium castaneum]>gi|270012120|gb|EFA08568.1| hypothetical protein TcasGA2_TC006223 [Tribolium castaneum] -- -- -- -- -- K05961 dnk deoxynucleoside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05961 P70683 551 1.1e-54 Platelet-activating factor acetylhydrolase OS=Cavia porcellus GN=PLA2G7 PE=2 SV=1 PF03403//PF00005//PF01121//PF02367 Platelet-activating factor acetylhydrolase, isoform II//ABC transporter//Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0015940//GO:0015937//GO:0046486//GO:0002949//GO:0016042 pantothenate biosynthetic process//coenzyme A biosynthetic process//glycerolipid metabolic process//tRNA threonylcarbamoyladenosine modification//lipid catabolic process GO:0005524//GO:0003847//GO:0004140//GO:0016887 ATP binding//1-alkyl-2-acetylglycerophosphocholine esterase activity//dephospho-CoA kinase activity//ATPase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4235 Mitochondrial thymidine kinase 2/deoxyguanosine kinase Cluster-8309.29595 BF_2 134.14 0.87 6738 270012147 EFA08595.1 7412 0.0e+00 hypothetical protein TcasGA2_TC006253 [Tribolium castaneum] 665401438 NM_166190.4 299 1.87886e-152 Drosophila melanogaster unc-104 ortholog (unc-104), transcript variant C, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5457 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF00959//PF00498//PF00225//PF05014//PF05171//PF10390//PF07353 Phage lysozyme//FHA domain//Kinesin motor domain//Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//RNA polymerase II elongation factor ELL//Uroplakin II GO:0006206//GO:0006368//GO:0016998//GO:0007017//GO:0061024//GO:0005975//GO:0006826//GO:0007018//GO:0009159//GO:0009253 pyrimidine nucleobase metabolic process//transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//microtubule-based process//membrane organization//carbohydrate metabolic process//iron ion transport//microtubule-based movement//deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process GO:0008017//GO:0003777//GO:0005515//GO:0003796//GO:0070694//GO:0005524//GO:0050144 microtubule binding//microtubule motor activity//protein binding//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//ATP binding//nucleoside deoxyribosyltransferase activity GO:0030176//GO:0008023//GO:0005874//GO:0045298 integral component of endoplasmic reticulum membrane//transcription elongation factor complex//microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.29596 BF_2 10.13 0.49 1155 332375791 AEE63036.1 260 5.3e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 156 2.5e-09 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.29598 BF_2 10.12 0.38 1403 270002027 EEZ98474.1 424 6.2e-39 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02176 TRAF-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.29602 BF_2 630.11 8.13 3531 91078836 XP_971451.1 1905 2.9e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 1.86307e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.4e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01120//PF01546 Alpha-L-fucosidase//Peptidase family M20/M25/M40 GO:0005975//GO:0006508//GO:0008152 carbohydrate metabolic process//proteolysis//metabolic process GO:0016805//GO:0008237//GO:0034701//GO:0004560//GO:0016787 dipeptidase activity//metallopeptidase activity//tripeptidase activity//alpha-L-fucosidase activity//hydrolase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.29603 BF_2 137.15 2.33 2749 91077022 XP_976032.1 152 4.2e-07 PREDICTED: uncharacterized protein LOC655336 [Tribolium castaneum]>gi|270001753|gb|EEZ98200.1| hypothetical protein TcasGA2_TC000630 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29604 BF_2 79.84 1.69 2261 642923289 XP_008193692.1 459 8.8e-43 PREDICTED: uncharacterized protein LOC103313098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.29605 BF_2 31.00 1.61 1095 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29606 BF_2 286.69 3.13 4124 642921841 XP_008199342.1 4742 0.0e+00 PREDICTED: adenylate cyclase type 6 [Tribolium castaneum] 195135626 XM_002012198.1 231 7.25092e-115 Drosophila mojavensis GI16861 (Dmoj\GI16861), mRNA K08045 ADCY5 adenylate cyclase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08045 P40144 2163 1.7e-241 Adenylate cyclase type 5 OS=Oryctolagus cuniculus GN=ADCY5 PE=1 SV=1 PF00211//PF07086//PF06327//PF07701 Adenylate and Guanylate cyclase catalytic domain//Jagunal, ER re-organisation during oogenesis//Domain of Unknown Function (DUF1053)//Heme NO binding associated GO:0009190//GO:0035556//GO:0006171//GO:0007029//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//cAMP biosynthetic process//endoplasmic reticulum organization//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0004016//GO:0004383 phosphorus-oxygen lyase activity//adenylate cyclase activity//guanylate cyclase activity GO:0005886//GO:0005789 plasma membrane//endoplasmic reticulum membrane KOG3619 Adenylate/guanylate cyclase Cluster-8309.29609 BF_2 2.00 0.60 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29611 BF_2 123.00 8.48 894 91086395 XP_974833.1 474 6.3e-45 PREDICTED: THAP domain-containing protein 4 [Tribolium castaneum]>gi|270009830|gb|EFA06278.1| hypothetical protein TcasGA2_TC009144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q642B6 320 1.9e-28 THAP domain-containing protein 4 OS=Rattus norvegicus GN=Thap4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29612 BF_2 175.60 10.76 970 766935896 XP_011500333.1 177 1.9e-10 PREDICTED: THAP domain-containing protein 1 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02344//PF10186//PF05485//PF14817 Myc leucine zipper domain//Vacuolar sorting 38 and autophagy-related subunit 14//THAP domain//HAUS augmin-like complex subunit 5 GO:0010508//GO:0006355//GO:0051225 positive regulation of autophagy//regulation of transcription, DNA-templated//spindle assembly GO:0003700//GO:0003676 transcription factor activity, sequence-specific DNA binding//nucleic acid binding GO:0070652//GO:0005667//GO:0005634 HAUS complex//transcription factor complex//nucleus -- -- Cluster-8309.29614 BF_2 33.23 0.68 2324 91076316 XP_969753.1 1330 9.0e-144 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 O75191 1006 1.4e-107 Xylulose kinase OS=Homo sapiens GN=XYLB PE=1 SV=3 PF02782//PF08114//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//ATPase proteolipid family//FGGY family of carbohydrate kinases, N-terminal domain GO:0005975//GO:0050790 carbohydrate metabolic process//regulation of catalytic activity GO:0016773//GO:0030234 phosphotransferase activity, alcohol group as acceptor//enzyme regulator activity -- -- KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.29615 BF_2 23.32 0.34 3165 91076316 XP_969753.1 1206 2.9e-129 PREDICTED: xylulose kinase [Tribolium castaneum]>gi|270002483|gb|EEZ98930.1| hypothetical protein TcasGA2_TC004550 [Tribolium castaneum] -- -- -- -- -- K00854 xylB, XYLB xylulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00854 Q3MIF4 905 9.7e-96 Xylulose kinase OS=Rattus norvegicus GN=Xylb PE=2 SV=1 PF02782//PF08114//PF00370//PF02723 FGGY family of carbohydrate kinases, C-terminal domain//ATPase proteolipid family//FGGY family of carbohydrate kinases, N-terminal domain//Non-structural protein NS3/Small envelope protein E GO:0005975//GO:0050790 carbohydrate metabolic process//regulation of catalytic activity GO:0030234//GO:0016773 enzyme regulator activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG2531 Sugar (pentulose and hexulose) kinases Cluster-8309.29616 BF_2 39.00 1.39 1462 607361803 EZA56073.1 149 5.0e-07 hypothetical protein X777_03918 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.29617 BF_2 3640.20 58.21 2903 270001368 EEZ97815.1 2124 9.6e-236 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 142 1.51753e-65 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 948 9.2e-101 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.29620 BF_2 205.00 5.83 1759 642911670 XP_008200694.1 402 2.8e-36 PREDICTED: chondroitin sulfate proteoglycan 4 isoform X2 [Tribolium castaneum]>gi|642911672|ref|XP_008200695.1| PREDICTED: chondroitin sulfate proteoglycan 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29621 BF_2 76.74 1.27 2818 642934752 XP_008197796.1 1204 4.5e-129 PREDICTED: transmembrane protein 129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IJ33 690 7.4e-71 E3 ubiquitin-protein ligase TM129 OS=Xenopus tropicalis GN=tmem129 PE=2 SV=1 PF00181//PF05203 Ribosomal Proteins L2, RNA binding domain//Hom_end-associated Hint GO:0006412//GO:0030908//GO:0042254 translation//protein splicing//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.29622 BF_2 691.33 60.14 768 478250587 ENN71079.1 424 3.4e-39 hypothetical protein YQE_12013, partial [Dendroctonus ponderosae]>gi|546672941|gb|ERL84649.1| hypothetical protein D910_02077 [Dendroctonus ponderosae] -- -- -- -- -- K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q8LFQ6 270 1.0e-22 Glutaredoxin-C4 OS=Arabidopsis thaliana GN=GRXC4 PE=2 SV=2 PF00462//PF00085//PF01323 Glutaredoxin//Thioredoxin//DSBA-like thioredoxin domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG1752 Glutaredoxin and related proteins Cluster-8309.29625 BF_2 686.05 12.46 2590 642921119 XP_975344.2 2219 8.3e-247 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum]>gi|270006197|gb|EFA02645.1| hypothetical protein TcasGA2_TC008366 [Tribolium castaneum] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q0VD19 1161 1.6e-125 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.29632 BF_2 160.17 2.32 3178 642934019 XP_008197606.1 669 5.5e-67 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 149 2.13618e-69 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9Y365 309 1.3e-26 PCTP-like protein OS=Homo sapiens GN=STARD10 PE=1 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.29637 BF_2 5.00 0.60 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29639 BF_2 541.76 9.74 2614 189233731 XP_971025.2 2325 4.3e-259 PREDICTED: kinesin-like protein KIF3A [Tribolium castaneum]>gi|270015046|gb|EFA11494.1| hypothetical protein TcasGA2_TC014207 [Tribolium castaneum] -- -- -- -- -- K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q9Y496 1393 2.1e-152 Kinesin-like protein KIF3A OS=Homo sapiens GN=KIF3A PE=1 SV=4 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0005875//GO:0005874//GO:0045298 microtubule associated complex//microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.2964 BF_2 15.91 0.38 2036 642928441 XP_008193786.1 225 1.1e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29640 BF_2 55.24 0.97 2672 189233731 XP_971025.2 2325 4.4e-259 PREDICTED: kinesin-like protein KIF3A [Tribolium castaneum]>gi|270015046|gb|EFA11494.1| hypothetical protein TcasGA2_TC014207 [Tribolium castaneum] -- -- -- -- -- K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q9Y496 1393 2.1e-152 Kinesin-like protein KIF3A OS=Homo sapiens GN=KIF3A PE=1 SV=4 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0003777//GO:0008017 ATP binding//microtubule motor activity//microtubule binding GO:0005875//GO:0005874//GO:0045298 microtubule associated complex//microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.29641 BF_2 489.00 9.57 2425 270001693 EEZ98140.1 1845 1.8e-203 hypothetical protein TcasGA2_TC000565 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLI3 832 2.2e-87 Membrane metallo-endopeptidase-like 1 OS=Mus musculus GN=Mmel1 PE=1 SV=1 PF01431//PF00233//PF05649 Peptidase family M13//3'5'-cyclic nucleotide phosphodiesterase//Peptidase family M13 GO:0006144//GO:0007165//GO:0006508 purine nucleobase metabolic process//signal transduction//proteolysis GO:0004114//GO:0004222 3',5'-cyclic-nucleotide phosphodiesterase activity//metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.29645 BF_2 7.60 0.50 923 646713645 KDR17927.1 356 3.1e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 3.8e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29646 BF_2 77.59 2.57 1550 91092160 XP_967690.1 701 5.2e-71 PREDICTED: RNA-binding protein 24-B [Tribolium castaneum]>gi|270014448|gb|EFA10896.1| hypothetical protein TcasGA2_TC001720 [Tribolium castaneum] 462310806 APGK01047199.1 66 1.42045e-23 Dendroctonus ponderosae Seq01047209, whole genome shotgun sequence -- -- -- -- Q9I8B3 420 8.2e-40 RNA-binding protein 24-B OS=Xenopus laevis GN=rbm24-b PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily) Cluster-8309.29647 BF_2 83.88 5.47 929 91093429 XP_968933.1 257 9.5e-20 PREDICTED: uncharacterized protein LOC657376 [Tribolium castaneum]>gi|270015461|gb|EFA11909.1| hypothetical protein TcasGA2_TC004066 [Tribolium castaneum] -- -- -- -- -- K18157 TMEM126A transmembrane protein 126A http://www.genome.jp/dbget-bin/www_bget?ko:K18157 -- -- -- -- PF03554 UL73 viral envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.29648 BF_2 413.07 5.41 3482 91092160 XP_967690.1 781 6.2e-80 PREDICTED: RNA-binding protein 24-B [Tribolium castaneum]>gi|270014448|gb|EFA10896.1| hypothetical protein TcasGA2_TC001720 [Tribolium castaneum] 645005484 XM_001606127.3 58 9.04415e-19 PREDICTED: Nasonia vitripennis RNA-binding protein 24-A-like (LOC100122565), transcript variant X3, mRNA -- -- -- -- Q9I8B3 420 1.8e-39 RNA-binding protein 24-B OS=Xenopus laevis GN=rbm24-b PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily) Cluster-8309.29649 BF_2 1051.31 16.96 2881 478258529 ENN78604.1 491 2.2e-46 hypothetical protein YQE_04971, partial [Dendroctonus ponderosae] -- -- -- -- -- K10694 ZNRF1_2 E3 ubiquitin-protein ligase ZNRF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10694 F7EP40 390 4.6e-36 E3 ubiquitin-protein ligase znrf1 OS=Xenopus tropicalis GN=znrf1 PE=3 SV=1 PF00097//PF12678//PF08120//PF17123//PF12906//PF14634//PF13639//PF15926//PF01612 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//Tamulustoxin family//RING-like zinc finger//RING-variant domain//zinc-RING finger domain//Ring finger domain//E3 ubiquitin-protein ligase RNF220//3'-5' exonuclease GO:0006810//GO:0016567//GO:0006139//GO:0090263//GO:0009405 transport//protein ubiquitination//nucleobase-containing compound metabolic process//positive regulation of canonical Wnt signaling pathway//pathogenesis GO:0005515//GO:0019870//GO:0046872//GO:0008408//GO:0003676//GO:0008270 protein binding//potassium channel inhibitor activity//metal ion binding//3'-5' exonuclease activity//nucleic acid binding//zinc ion binding GO:0005576 extracellular region KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.29652 BF_2 39.93 1.56 1361 642931818 XP_008196746.1 1472 1.8e-160 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q5RA96 1114 2.4e-120 GMP synthase [glutamine-hydrolyzing] OS=Pongo abelii GN=GMPS PE=2 SV=1 PF00958 GMP synthase C terminal domain GO:0006536//GO:0006144//GO:0006164//GO:0006177 glutamate metabolic process//purine nucleobase metabolic process//purine nucleotide biosynthetic process//GMP biosynthetic process GO:0003922//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//ATP binding -- -- KOG1622 GMP synthase Cluster-8309.29653 BF_2 938.65 6.99 5904 189233727 XP_970593.2 2892 0.0e+00 PREDICTED: AP-3 complex subunit beta-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12397 AP3B AP-3 complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12397 Q13367 2115 8.9e-236 AP-3 complex subunit beta-2 OS=Homo sapiens GN=AP3B2 PE=1 SV=2 PF13181//PF08492//PF13174//PF01602//PF02985//PF02535//PF00330//PF13371//PF13374//PF00515//PF09726//PF02862//PF13414//PF02486 Tetratricopeptide repeat//SRP72 RNA-binding domain//Tetratricopeptide repeat//Adaptin N terminal region//HEAT repeat//ZIP Zinc transporter//Aconitase family (aconitate hydratase)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Transmembrane protein//DDHD domain//TPR repeat//Replication initiation factor GO:0030001//GO:0008152//GO:0006265//GO:0055085//GO:0006614//GO:0006270//GO:0016192//GO:0006886 metal ion transport//metabolic process//DNA topological change//transmembrane transport//SRP-dependent cotranslational protein targeting to membrane//DNA replication initiation//vesicle-mediated transport//intracellular protein transport GO:0046873//GO:0008312//GO:0046872//GO:0003677//GO:0005515//GO:0003916 metal ion transmembrane transporter activity//7S RNA binding//metal ion binding//DNA binding//protein binding//DNA topoisomerase activity GO:0016020//GO:0030117//GO:0016021//GO:0048500 membrane//membrane coat//integral component of membrane//signal recognition particle KOG1060 Vesicle coat complex AP-3, beta subunit Cluster-8309.29654 BF_2 265.12 3.29 3659 642912135 XP_008200821.1 3329 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 3-like [Tribolium castaneum] -- -- -- -- -- K08628 ADAMTS14 a disintegrin and metalloproteinase with thrombospondin motifs 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08628 Q8WXS8 1504 3.9e-165 A disintegrin and metalloproteinase with thrombospondin motifs 14 OS=Homo sapiens GN=ADAMTS14 PE=2 SV=2 PF08686//PF01421//PF05372//PF00413 PLAC (protease and lacunin) domain//Reprolysin (M12B) family zinc metalloprotease//Delta lysin family//Matrixin GO:0019836//GO:0006508 hemolysis by symbiont of host erythrocytes//proteolysis GO:0008270//GO:0004222//GO:0008233 zinc ion binding//metalloendopeptidase activity//peptidase activity GO:0031012//GO:0005576 extracellular matrix//extracellular region -- -- Cluster-8309.29657 BF_2 3.77 0.56 567 662207644 XP_008477334.1 178 8.4e-11 PREDICTED: zinc finger protein 721-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7KQZ4 160 4.2e-10 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.29658 BF_2 194.59 1.59 5416 546678611 ERL89193.1 1404 5.5e-152 hypothetical protein D910_06567 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U481 630 1.3e-63 Major facilitator superfamily domain-containing protein 12 OS=Mus musculus GN=Mfsd12 PE=1 SV=1 PF07690//PF00171//PF04827 Major Facilitator Superfamily//Aldehyde dehydrogenase family//Plant transposon protein GO:0008152//GO:0055085//GO:0055114 metabolic process//transmembrane transport//oxidation-reduction process GO:0016788//GO:0016491 hydrolase activity, acting on ester bonds//oxidoreductase activity GO:0016021 integral component of membrane KOG4830 Predicted sugar transporter Cluster-8309.29659 BF_2 15.75 0.69 1247 665785084 XP_008545278.1 755 2.3e-77 PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring isoform X3 [Microplitis demolitor]>gi|665785086|ref|XP_008545282.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring isoform X3 [Microplitis demolitor] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P51648 694 1.1e-71 Fatty aldehyde dehydrogenase OS=Homo sapiens GN=ALDH3A2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.29661 BF_2 925.98 5.75 7023 642926249 XP_974073.3 1626 1.3e-177 PREDICTED: mannose-1-phosphate guanyltransferase beta [Tribolium castaneum]>gi|270009027|gb|EFA05475.1| hypothetical protein TcasGA2_TC015659 [Tribolium castaneum] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q295Y7 1534 2.5e-168 Mannose-1-phosphate guanyltransferase beta OS=Drosophila pseudoobscura pseudoobscura GN=GA10892 PE=3 SV=1 PF09270//PF01128//PF02932//PF00483//PF08671//PF06459//PF07959//PF00076 Beta-trefoil DNA-binding domain//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//Neurotransmitter-gated ion-channel transmembrane region//Nucleotidyl transferase//Anti-repressor SinI//Ryanodine Receptor TM 4-6//L-fucokinase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006816//GO:0008299//GO:0006355//GO:0006694//GO:0006874//GO:0009058//GO:0006811 calcium ion transport//isoprenoid biosynthetic process//regulation of transcription, DNA-templated//steroid biosynthetic process//cellular calcium ion homeostasis//biosynthetic process//ion transport GO:0000982//GO:0016772//GO:0000978//GO:0016779//GO:0050518//GO:0046983//GO:0005219//GO:0003676 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//transferase activity, transferring phosphorus-containing groups//RNA polymerase II core promoter proximal region sequence-specific DNA binding//nucleotidyltransferase activity//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//protein dimerization activity//ryanodine-sensitive calcium-release channel activity//nucleic acid binding GO:0016021//GO:0005622//GO:0005634//GO:0016020 integral component of membrane//intracellular//nucleus//membrane KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.29665 BF_2 209.02 1.42 6428 642928935 XP_008195623.1 3946 0.0e+00 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K17426 MRPL45 large subunit ribosomal protein L45 http://www.genome.jp/dbget-bin/www_bget?ko:K17426 Q9VCX1 1021 7.0e-109 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF00595//PF02188//PF13180//PF07961//PF02196 PDZ domain (Also known as DHR or GLGF)//GoLoco motif//PDZ domain//MBA1-like protein//Raf-like Ras-binding domain GO:0032979//GO:0007165 protein insertion into mitochondrial membrane from inner side//signal transduction GO:0005515//GO:0030695//GO:0005057 protein binding//GTPase regulator activity//receptor signaling protein activity GO:0005743 mitochondrial inner membrane KOG4599 Putative mitochondrial/chloroplast ribosomal protein L45 Cluster-8309.29667 BF_2 227.00 7.31 1586 332373850 AEE62066.1 699 9.1e-71 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13239 PECI peroxisomal 3,2-trans-enoyl-CoA isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K13239 Q5XIC0 481 7.1e-47 Enoyl-CoA delta isomerase 2, mitochondrial OS=Rattus norvegicus GN=Eci2 PE=1 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG0016 Enoyl-CoA hydratase/isomerase Cluster-8309.29668 BF_2 120.20 2.63 2198 478254032 ENN74324.1 1869 2.7e-206 hypothetical protein YQE_09295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29674 BF_2 2498.72 13.83 7846 642910328 XP_008200285.1 9638 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270014917|gb|EFA11365.1| hypothetical protein TcasGA2_TC011522 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 2979 0.0e+00 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF08545//PF00108//PF00107//PF02052//PF00975//PF00106 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain//Zinc-binding dehydrogenase//Gallidermin//Thioesterase domain//short chain dehydrogenase GO:0008152//GO:0006633//GO:0009058//GO:0055114//GO:0042742//GO:0042967 metabolic process//fatty acid biosynthetic process//biosynthetic process//oxidation-reduction process//defense response to bacterium//acyl-carrier-protein biosynthetic process GO:0004316//GO:0016747//GO:0004319//GO:0016788//GO:0004320//GO:0016491//GO:0016295//GO:0000166//GO:0008270//GO:0016296//GO:0004314//GO:0004313//GO:0004315//GO:0004317 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity//transferase activity, transferring acyl groups other than amino-acyl groups//enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity//hydrolase activity, acting on ester bonds//oleoyl-[acyl-carrier-protein] hydrolase activity//oxidoreductase activity//myristoyl-[acyl-carrier-protein] hydrolase activity//nucleotide binding//zinc ion binding//palmitoyl-[acyl-carrier-protein] hydrolase activity//[acyl-carrier-protein] S-malonyltransferase activity//[acyl-carrier-protein] S-acetyltransferase activity//3-oxoacyl-[acyl-carrier-protein] synthase activity//3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity GO:0005576//GO:0005835 extracellular region//fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.29677 BF_2 655.37 5.37 5389 642935919 XP_008198229.1 1824 1.1e-200 PREDICTED: dual specificity protein phosphatase Mpk3 isoform X2 [Tribolium castaneum]>gi|270013985|gb|EFA10433.1| hypothetical protein TcasGA2_TC012676 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9VVW5 864 9.4e-91 Dual specificity protein phosphatase Mpk3 OS=Drosophila melanogaster GN=Mkp3 PE=1 SV=2 PF05706//PF00102//PF04179//PF00782//PF00020 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain//TNFR/NGFR cysteine-rich region GO:0019988//GO:0006570//GO:0006470//GO:0035335 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation//peptidyl-tyrosine dephosphorylation GO:0004725//GO:0005515//GO:0008138//GO:0017017//GO:0043399//GO:0004721 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//MAP kinase tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//phosphoprotein phosphatase activity -- -- KOG1717 Dual specificity phosphatase Cluster-8309.29679 BF_2 135.59 1.35 4498 546676381 ERL87403.1 602 4.6e-59 hypothetical protein D910_04798 [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 359 2.8e-32 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF00155//PF01212 Aminotransferase class I and II//Beta-eliminating lyase GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG1368 Threonine aldolase Cluster-8309.29680 BF_2 441.14 9.10 2315 642910317 XP_008200281.1 1312 1.1e-141 PREDICTED: dimethyladenosine transferase 1, mitochondrial [Tribolium castaneum] -- -- -- -- -- K15266 TFB1M dimethyladenosine transferase 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K15266 Q7T0W5 857 2.6e-90 Dimethyladenosine transferase 1, mitochondrial OS=Xenopus laevis GN=tfb1m PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.29683 BF_2 280.74 1.22 9907 478250015 ENN70521.1 4003 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 573901209 XM_006638269.1 121 2.46448e-53 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2864 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF00612//PF06414//PF00063//PF00437//PF06017 IQ calmodulin-binding motif//Zeta toxin//Myosin head (motor domain)//Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding GO:0006810 transport GO:0005515//GO:0005524//GO:0016301//GO:0003774 protein binding//ATP binding//kinase activity//motor activity GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.29684 BF_2 73.00 2.69 1424 270006713 EFA03161.1 906 8.1e-95 hypothetical protein TcasGA2_TC013080 [Tribolium castaneum] -- -- -- -- -- K06054 HES1 hairy and enhancer of split 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06054 P35428 315 1.1e-27 Transcription factor HES-1 OS=Mus musculus GN=Hes1 PE=1 SV=1 PF07527//PF00010 Hairy Orange//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- KOG4304 Transcriptional repressors of the hairy/E(spl) family (contains HLH) Cluster-8309.29685 BF_2 586.30 29.27 1125 642937160 XP_969386.2 1065 2.3e-113 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] -- -- -- -- -- K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 Q1RMU3 561 2.7e-56 Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus GN=P4HA1 PE=1 SV=1 PF08336 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0018401//GO:0006525//GO:0006560//GO:0055114 peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//proline metabolic process//oxidation-reduction process GO:0004656//GO:0016702 procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005783 endoplasmic reticulum KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.29686 BF_2 1430.00 38.15 1855 91084199 XP_967748.1 2385 3.3e-266 PREDICTED: T-complex protein 1 subunit zeta [Tribolium castaneum]>gi|270009362|gb|EFA05810.1| hypothetical protein TcasGA2_TC030760 [Tribolium castaneum] 242013594 XM_002427443.1 191 5.55863e-93 Pediculus humanus corporis T-complex protein 1 subunit zeta, putative, mRNA K09498 CCT6 T-complex protein 1 subunit zeta http://www.genome.jp/dbget-bin/www_bget?ko:K09498 P80317 1984 4.3e-221 T-complex protein 1 subunit zeta OS=Mus musculus GN=Cct6a PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0359 Chaperonin complex component, TCP-1 zeta subunit (CCT6) Cluster-8309.29687 BF_2 1215.81 22.31 2567 91086165 XP_970259.1 2753 9.8e-309 PREDICTED: ATP-dependent zinc metalloprotease YME1 homolog [Tribolium castaneum]>gi|270009883|gb|EFA06331.1| hypothetical protein TcasGA2_TC009202 [Tribolium castaneum] 759074133 XM_011348443.1 98 3.86167e-41 PREDICTED: Cerapachys biroi ATP-dependent zinc metalloprotease YME1 homolog (LOC105284713), transcript variant X3, mRNA K08955 YME1 ATP-dependent metalloprotease http://www.genome.jp/dbget-bin/www_bget?ko:K08955 P54813 1417 3.4e-155 ATP-dependent zinc metalloprotease YME1 homolog OS=Caenorhabditis elegans GN=ymel-1 PE=3 SV=2 PF00004//PF01434//PF05496//PF00158//PF06068//PF01695//PF07728//PF02562//PF06414//PF02367 ATPase family associated with various cellular activities (AAA)//Peptidase family M41//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006355//GO:0006281//GO:0030163//GO:0002949//GO:0006310//GO:0006508 regulation of transcription, DNA-templated//DNA repair//protein catabolic process//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis GO:0016301//GO:0016887//GO:0008134//GO:0005524//GO:0004222//GO:0009378//GO:0017111//GO:0003678 kinase activity//ATPase activity//transcription factor binding//ATP binding//metalloendopeptidase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//DNA helicase activity GO:0009379//GO:0016020//GO:0005667//GO:0005657 Holliday junction helicase complex//membrane//transcription factor complex//replication fork KOG0734 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.29690 BF_2 330.33 5.13 2980 478251696 ENN72150.1 1472 4.0e-160 hypothetical protein YQE_11207, partial [Dendroctonus ponderosae]>gi|546680948|gb|ERL91122.1| hypothetical protein D910_08463 [Dendroctonus ponderosae] -- -- -- -- -- K14308 NUP54, NUP57 nuclear pore complex protein Nup54 http://www.genome.jp/dbget-bin/www_bget?ko:K14308 Q8BTS4 726 5.2e-75 Nuclear pore complex protein Nup54 OS=Mus musculus GN=Nup54 PE=1 SV=1 PF00969 Class II histocompatibility antigen, beta domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG3091 Nuclear pore complex, p54 component (sc Nup57) Cluster-8309.29691 BF_2 158.00 3.82 2019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00951 Arterivirus GL envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.29692 BF_2 332.81 5.64 2754 91092022 XP_970951.1 743 1.2e-75 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 629 8.5e-64 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.29695 BF_2 433.00 12.63 1721 91085067 XP_966737.1 821 7.0e-85 PREDICTED: actin-related protein 2/3 complex subunit 4 [Tribolium castaneum]>gi|270009038|gb|EFA05486.1| hypothetical protein TcasGA2_TC015671 [Tribolium castaneum] 241714781 XM_002413479.1 117 7.04899e-52 Ixodes scapularis conserved hypothetical protein, mRNA K05755 ARPC4 actin related protein 2/3 complex, subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05755 Q148J6 749 6.5e-78 Actin-related protein 2/3 complex subunit 4 OS=Bos taurus GN=ARPC4 PE=1 SV=3 PF04114//PF05856 Gaa1-like, GPI transamidase component//ARP2/3 complex 20 kDa subunit (ARPC4) GO:0030041//GO:0034314 actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0016021//GO:0015629//GO:0005885//GO:0005856//GO:0042765 integral component of membrane//actin cytoskeleton//Arp2/3 protein complex//cytoskeleton//GPI-anchor transamidase complex KOG1876 Actin-related protein Arp2/3 complex, subunit ARPC4 Cluster-8309.29697 BF_2 75.86 1.42 2521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.29700 BF_2 7.00 0.58 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29701 BF_2 125.75 1.12 4981 642933730 XP_008197339.1 4432 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 6.9e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.29702 BF_2 529.26 14.17 1850 91076404 XP_969308.1 1708 1.1e-187 PREDICTED: protein RMD5 homolog A [Tribolium castaneum]>gi|270002561|gb|EEZ99008.1| hypothetical protein TcasGA2_TC004876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H871 1091 1.5e-117 Protein RMD5 homolog A OS=Homo sapiens GN=RMND5A PE=1 SV=1 PF16740//PF07352//PF07926//PF04977//PF09177//PF10473 Spindle and kinetochore-associated protein 2//Bacteriophage Mu Gam like protein//TPR/MLP1/MLP2-like protein//Septum formation initiator//Syntaxin 6, N-terminal//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0048193//GO:0042262//GO:0007049//GO:0007059//GO:0007067//GO:0006606//GO:0000090//GO:0031110//GO:0051301 Golgi vesicle transport//DNA protection//cell cycle//chromosome segregation//mitotic nuclear division//protein import into nucleus//mitotic anaphase//regulation of microtubule polymerization or depolymerization//cell division GO:0003690//GO:0042803//GO:0008017//GO:0045502//GO:0008134 double-stranded DNA binding//protein homodimerization activity//microtubule binding//dynein binding//transcription factor binding GO:0005667//GO:0030286//GO:0016020//GO:0000940//GO:0045298//GO:0005876 transcription factor complex//dynein complex//membrane//condensed chromosome outer kinetochore//tubulin complex//spindle microtubule KOG2817 Predicted E3 ubiquitin ligase Cluster-8309.29703 BF_2 205.00 3.65 2639 91076500 XP_973094.1 2588 1.4e-289 PREDICTED: alkaline phosphatase-like [Tribolium castaneum] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 Q92058 1041 1.4e-111 Alkaline phosphatase, tissue-nonspecific isozyme OS=Gallus gallus GN=ALPL PE=2 SV=1 PF08170//PF01676//PF00549//PF00245 POPLD (NUC188) domain//Metalloenzyme superfamily//CoA-ligase//Alkaline phosphatase GO:0008152//GO:0051252//GO:0006396//GO:0008033 metabolic process//regulation of RNA metabolic process//RNA processing//tRNA processing GO:0003824//GO:0016791//GO:0004526//GO:0046872 catalytic activity//phosphatase activity//ribonuclease P activity//metal ion binding GO:0030677 ribonuclease P complex -- -- Cluster-8309.29705 BF_2 413.60 3.11 5850 642917952 XP_008198956.1 1655 4.7e-181 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 728 6.0e-75 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.29707 BF_2 24.57 0.48 2421 642938930 XP_008200093.1 1123 9.5e-120 PREDICTED: LOW QUALITY PROTEIN: probable cytochrome P450 6a23 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 849 2.3e-89 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067//PF15681//PF00876 Cytochrome P450//Lymphocyte activation family X//Innexin GO:0055114//GO:0051249//GO:0006955 oxidation-reduction process//regulation of lymphocyte activation//immune response GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005921 gap junction -- -- Cluster-8309.29709 BF_2 227.00 7.45 1562 91076846 XP_974788.1 2012 5.0e-223 PREDICTED: DDB1- and CUL4-associated factor 13 [Tribolium castaneum]>gi|270001818|gb|EEZ98265.1| hypothetical protein TcasGA2_TC000707 [Tribolium castaneum] -- -- -- -- -- K11806 WDSOF1 WD repeat and SOF domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11806 Q5ZLK1 1550 7.7e-171 DDB1- and CUL4-associated factor 13 OS=Gallus gallus GN=DCAF13 PE=2 SV=1 PF00400//PF08023//PF04053 WD domain, G-beta repeat//Frog antimicrobial peptide//Coatomer WD associated region GO:0006886//GO:0016192//GO:0006952 intracellular protein transport//vesicle-mediated transport//defense response GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0005576//GO:0030117 extracellular region//membrane coat KOG0268 Sof1-like rRNA processing protein (contains WD40 repeats) Cluster-8309.29710 BF_2 1590.90 13.33 5278 91082499 XP_972877.1 1497 8.9e-163 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU29 852 2.3e-89 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF00637//PF06701//PF16276//PF02066//PF04121//PF00569//PF04097 Region in Clathrin and VPS//Mib_herc2//Nucleophosmin C-terminal domain//Metallothionein family 11//Nuclear pore protein 84 / 107//Zinc finger, ZZ type//Nup93/Nic96 GO:0016567//GO:0006810//GO:0016192//GO:0006886 protein ubiquitination//transport//vesicle-mediated transport//intracellular protein transport GO:0004842//GO:0005507//GO:0046872//GO:0003676//GO:0008270 ubiquitin-protein transferase activity//copper ion binding//metal ion binding//nucleic acid binding//zinc ion binding GO:0005643 nuclear pore -- -- Cluster-8309.29712 BF_2 3.00 0.77 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29714 BF_2 8.00 1.10 591 91081147 XP_975562.1 188 6.1e-12 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270006377|gb|EFA02825.1| cytochrome P450 6BQ12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4U9 129 1.7e-06 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0016705//GO:0009055//GO:0005506//GO:0004497//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity//iron ion binding//monooxygenase activity//heme binding -- -- -- -- Cluster-8309.29715 BF_2 17.90 1.67 735 332372714 AEE61499.1 236 2.1e-17 unknown [Dendroctonus ponderosae]>gi|478259035|gb|ENN78981.1| hypothetical protein YQE_04565, partial [Dendroctonus ponderosae]>gi|546684157|gb|ERL93862.1| hypothetical protein D910_11148 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.29716 BF_2 868.96 20.03 2102 189234482 XP_970034.2 1101 2.9e-117 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270001732|gb|EEZ98179.1| hypothetical protein TcasGA2_TC000608 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8UWA5 340 2.1e-30 Carbonic anhydrase 2 OS=Tribolodon hakonensis GN=ca2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29718 BF_2 158.85 0.88 7814 642929402 XP_008195823.1 7372 0.0e+00 PREDICTED: unconventional myosin-Va isoform X2 [Tribolium castaneum] 766917087 XM_011503499.1 99 3.29574e-41 PREDICTED: Ceratosolen solmsi marchali unconventional myosin-Va (LOC105365325), mRNA K10357 MYO5 myosin V http://www.genome.jp/dbget-bin/www_bget?ko:K10357 Q9QYF3 4233 0.0e+00 Unconventional myosin-Va OS=Rattus norvegicus GN=Myo5a PE=1 SV=1 PF05902//PF01890//PF00612//PF11857//PF08437//PF00063 4.1 protein C-terminal domain (CTD)//Cobalamin synthesis G C-terminus//IQ calmodulin-binding motif//Domain of unknown function (DUF3377)//Glycosyl transferase family 8 C-terminal//Myosin head (motor domain) GO:0009103//GO:0009236 lipopolysaccharide biosynthetic process//cobalamin biosynthetic process GO:0005524//GO:0004222//GO:0005198//GO:0005515//GO:0003779//GO:0003774//GO:0008918 ATP binding//metalloendopeptidase activity//structural molecule activity//protein binding//actin binding//motor activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG0160 Myosin class V heavy chain Cluster-8309.29719 BF_2 9.00 2.24 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29722 BF_2 29.00 1.99 898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29723 BF_2 219.42 9.78 1226 189235746 XP_967247.2 407 5.1e-37 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 287 1.7e-24 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137 Adenosine-deaminase (editase) domain GO:0006807//GO:0006144//GO:0006396 nitrogen compound metabolic process//purine nucleobase metabolic process//RNA processing GO:0003723//GO:0004000 RNA binding//adenosine deaminase activity -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.29725 BF_2 36.40 0.43 3853 91083301 XP_974629.1 1378 4.1e-149 PREDICTED: alpha-methylacyl-CoA racemase [Tribolium castaneum]>gi|270007738|gb|EFA04186.1| hypothetical protein TcasGA2_TC014435 [Tribolium castaneum] -- -- -- -- -- K01796 E5.1.99.4, AMACR, mcr alpha-methylacyl-CoA racemase http://www.genome.jp/dbget-bin/www_bget?ko:K01796 O09174 1099 3.8e-118 Alpha-methylacyl-CoA racemase OS=Mus musculus GN=Amacr PE=1 SV=4 PF00536//PF04178//PF07647//PF02515 SAM domain (Sterile alpha motif)//Got1/Sft2-like family//SAM domain (Sterile alpha motif)//CoA-transferase family III GO:0008152//GO:0016192 metabolic process//vesicle-mediated transport GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.29726 BF_2 37.65 2.67 877 237820629 NP_001153782.1 889 4.7e-93 transmembrane protein 120B [Tribolium castaneum]>gi|270004540|gb|EFA00988.1| hypothetical protein TcasGA2_TC003901 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9U1M2 770 1.2e-80 Transmembrane protein 120 homolog OS=Drosophila melanogaster GN=CG32795 PE=1 SV=1 PF07851//PF16326 TMPIT-like protein//ABC transporter C-terminal domain -- -- GO:0003677 DNA binding GO:0016021 integral component of membrane KOG4758 Predicted membrane protein Cluster-8309.29727 BF_2 19.15 0.86 1221 91076494 XP_972946.1 372 5.8e-33 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 277 2.5e-23 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.2973 BF_2 5.00 0.97 502 642915881 XP_008196364.1 178 7.5e-11 PREDICTED: cuticle protein 65-like [Tribolium castaneum]>gi|270004064|gb|EFA00512.1| hypothetical protein TcasGA2_TC003376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29730 BF_2 117.01 1.97 2770 91076494 XP_972946.1 289 5.5e-23 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 221 1.8e-16 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29731 BF_2 552.14 6.30 3953 642921132 XP_008192700.1 4757 0.0e+00 PREDICTED: leucine--tRNA ligase, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270006203|gb|EFA02651.1| hypothetical protein TcasGA2_TC008372 [Tribolium castaneum] 684411112 XM_009178024.1 39 3.75014e-08 Opisthorchis viverrini hypothetical protein partial mRNA K01869 LARS, leuS leucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01869 Q9P2J5 3732 0.0e+00 Leucine--tRNA ligase, cytoplasmic OS=Homo sapiens GN=LARS PE=1 SV=2 PF08264//PF00133//PF09334 Anticodon-binding domain of tRNA//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0009098//GO:0009097//GO:0006418//GO:0006429//GO:0006450//GO:0009099 leucine biosynthetic process//isoleucine biosynthetic process//tRNA aminoacylation for protein translation//leucyl-tRNA aminoacylation//regulation of translational fidelity//valine biosynthetic process GO:0005524//GO:0004823//GO:0000166//GO:0004812//GO:0002161 ATP binding//leucine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity GO:0005737 cytoplasm KOG0437 Leucyl-tRNA synthetase Cluster-8309.29732 BF_2 89.67 1.88 2279 642927675 XP_008195360.1 1255 4.4e-135 PREDICTED: NAD kinase 2, mitochondrial, partial [Tribolium castaneum] -- -- -- -- -- K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 Q1HCL7 635 1.4e-64 NAD kinase 2, mitochondrial OS=Rattus norvegicus GN=Nadk2 PE=2 SV=1 PF03575//PF01513//PF00781 Peptidase family S51//ATP-NAD kinase//Diacylglycerol kinase catalytic domain GO:0008152//GO:0046497//GO:0006741//GO:0006508//GO:0006769 metabolic process//nicotinate nucleotide metabolic process//NADP biosynthetic process//proteolysis//nicotinamide metabolic process GO:0003951//GO:0016301//GO:0008236 NAD+ kinase activity//kinase activity//serine-type peptidase activity -- -- KOG4180 Predicted kinase Cluster-8309.29733 BF_2 136.01 6.63 1145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29736 BF_2 173.00 20.86 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29737 BF_2 53.00 25.92 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29738 BF_2 15.67 0.75 1161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29740 BF_2 1127.23 16.38 3166 270012489 EFA08937.1 358 6.3e-31 hypothetical protein TcasGA2_TC006644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JMD0 137 1.1e-06 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Mus musculus GN=Znf207 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29741 BF_2 986.65 8.82 4967 642932977 XP_008197213.1 329 2.3e-27 PREDICTED: BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JMD0 137 1.7e-06 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Mus musculus GN=Znf207 PE=2 SV=1 PF06003//PF10403 Survival motor neuron protein (SMN)//Rad4 beta-hairpin domain 1 GO:0006397 mRNA processing GO:0003677//GO:0003723 DNA binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.29745 BF_2 13.27 0.41 1641 478259624 ENN79477.1 917 5.0e-96 hypothetical protein YQE_04121, partial [Dendroctonus ponderosae] -- -- -- -- -- K13982 DDX4, VASA probable ATP-dependent RNA helicase DDX4 http://www.genome.jp/dbget-bin/www_bget?ko:K13982 P09052 699 3.9e-72 ATP-dependent RNA helicase vasa, isoform A OS=Drosophila melanogaster GN=vas PE=1 SV=3 PF06862//PF01297 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Zinc-uptake complex component A periplasmic GO:0030001 metal ion transport GO:0046872 metal ion binding GO:0005634 nucleus KOG0335 ATP-dependent RNA helicase Cluster-8309.29747 BF_2 308.45 5.72 2544 189238410 XP_001813192.1 393 4.4e-35 PREDICTED: uncharacterized protein LOC100141684 [Tribolium castaneum]>gi|270008536|gb|EFA04984.1| hypothetical protein TcasGA2_TC015062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29750 BF_2 24.79 0.54 2219 646711129 KDR16428.1 939 1.9e-98 Lipase 3 [Zootermopsis nevadensis] -- -- -- -- -- K14452 LIPF gastric triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14452 O46108 804 3.5e-84 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.29753 BF_2 348.00 8.39 2023 749786148 XP_011146725.1 471 3.2e-44 PREDICTED: vesicle transport protein SFT2B isoform X2 [Harpegnathos saltator]>gi|307199039|gb|EFN79763.1| Vesicle transport protein SFT2B [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- Q5SSN7 349 1.8e-31 Vesicle transport protein SFT2A OS=Mus musculus GN=Sft2d1 PE=1 SV=1 PF04178 Got1/Sft2-like family GO:0016192 vesicle-mediated transport -- -- -- -- KOG2887 Membrane protein involved in ER to Golgi transport Cluster-8309.29755 BF_2 6.84 0.39 1026 91089873 XP_971596.1 949 6.0e-100 PREDICTED: ruvB-like helicase 1 [Tribolium castaneum]>gi|270014274|gb|EFA10722.1| pontin [Tribolium castaneum] 552828675 XM_005847470.1 59 7.24335e-20 Chlorella variabilis hypothetical protein (CHLNCDRAFT_48800) mRNA, complete cds K04499 RUVBL1, RVB1, INO80H RuvB-like protein 1 (pontin 52) http://www.genome.jp/dbget-bin/www_bget?ko:K04499 Q0IFL2 827 3.5e-87 RuvB-like helicase 1 OS=Aedes aegypti GN=pont PE=3 SV=1 PF06068//PF05496//PF00004 TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0032508//GO:0006281 DNA recombination//DNA duplex unwinding//DNA repair GO:0009378//GO:0005524//GO:0003678 four-way junction helicase activity//ATP binding//DNA helicase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG1942 DNA helicase, TBP-interacting protein Cluster-8309.29757 BF_2 1702.12 16.18 4688 91089655 XP_974084.1 2180 5.0e-242 PREDICTED: protein wntless [Tribolium castaneum]>gi|270011339|gb|EFA07787.1| hypothetical protein TcasGA2_TC005345 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4LC58 1542 2.0e-169 Protein wntless OS=Drosophila virilis GN=wls PE=3 SV=1 PF00651 BTB/POZ domain GO:0016055 Wnt signaling pathway GO:0017147//GO:0005515 Wnt-protein binding//protein binding -- -- -- -- Cluster-8309.29761 BF_2 3372.68 37.66 4033 91094941 XP_967472.1 5527 0.0e+00 PREDICTED: coatomer subunit alpha [Tribolium castaneum]>gi|270016760|gb|EFA13206.1| hypothetical protein TcasGA2_TC016033 [Tribolium castaneum] 642939609 XM_962379.3 577 0 PREDICTED: Tribolium castaneum coatomer subunit alpha (LOC655819), mRNA K05236 COPA coatomer protein complex, subunit alpha (xenin) http://www.genome.jp/dbget-bin/www_bget?ko:K05236 P53621 4596 0.0e+00 Coatomer subunit alpha OS=Homo sapiens GN=COPA PE=1 SV=2 PF00400//PF06957//PF13414//PF04053 WD domain, G-beta repeat//Coatomer (COPI) alpha subunit C-terminus//TPR repeat//Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG0292 Vesicle coat complex COPI, alpha subunit Cluster-8309.29762 BF_2 878.13 7.95 4909 642914151 XP_008201566.1 5261 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 Q6ZN16 2572 7.5e-289 Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens GN=MAP3K15 PE=1 SV=2 PF07647//PF07714//PF00069 SAM domain (Sterile alpha motif)//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG4279 Serine/threonine protein kinase Cluster-8309.29765 BF_2 27.56 0.64 2097 478254618 ENN74861.1 748 2.5e-76 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 9.5e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF07043//PF06687//PF00230//PF05094 Protein of unknown function (DUF1328)//SUR7/PalI family//Major intrinsic protein//Late expression factor 9 (LEF-9) GO:0006810//GO:0019083 transport//viral transcription GO:0005215 transporter activity GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8309.29768 BF_2 1357.54 69.02 1110 91087325 XP_975591.1 403 1.3e-36 PREDICTED: ribonuclease kappa [Tribolium castaneum]>gi|270009525|gb|EFA05973.1| hypothetical protein TcasGA2_TC008797 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSF5 312 2.0e-27 Ribonuclease kappa OS=Drosophila melanogaster GN=CG40127 PE=3 SV=1 PF00649 Copper fist DNA binding domain GO:0009303//GO:0006355//GO:0051252 rRNA transcription//regulation of transcription, DNA-templated//regulation of RNA metabolic process GO:0003677//GO:0005507//GO:0004521//GO:0003700 DNA binding//copper ion binding//endoribonuclease activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.29770 BF_2 54.00 26.12 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29772 BF_2 331.67 6.95 2284 189240899 XP_972980.2 1372 1.2e-148 PREDICTED: protein numb isoform X1 [Tribolium castaneum] 642934703 XM_008199556.1 373 0 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X2, mRNA K06057 NUMBL numb http://www.genome.jp/dbget-bin/www_bget?ko:K06057 P16554 1074 1.8e-115 Protein numb OS=Drosophila melanogaster GN=numb PE=1 SV=2 PF07353//PF00640//PF14719//PF08168 Uroplakin II//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID)//NUC205 domain GO:0061024 membrane organization GO:0005515 protein binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG3537 Adaptor protein NUMB Cluster-8309.29773 BF_2 120.00 2.25 2520 189238529 XP_972715.2 1384 5.4e-150 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009088|gb|EFA05536.1| hypothetical protein TcasGA2_TC015723 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 749 9.5e-78 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF01266//PF00732//PF07992//PF05834//PF05199 FAD dependent oxidoreductase//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.29774 BF_2 321.00 7.01 2203 91094133 XP_966520.1 2156 1.4e-239 PREDICTED: delta(24)-sterol reductase [Tribolium castaneum]>gi|270010866|gb|EFA07314.1| hypothetical protein TcasGA2_TC015907 [Tribolium castaneum] -- -- -- -- -- K09828 DHCR24 delta24-sterol reductase http://www.genome.jp/dbget-bin/www_bget?ko:K09828 Q15392 917 2.7e-97 Delta(24)-sterol reductase OS=Homo sapiens GN=DHCR24 PE=1 SV=2 PF01565 FAD binding domain GO:0006040//GO:0055114 amino sugar metabolic process//oxidation-reduction process GO:0050660//GO:0008762//GO:0016491 flavin adenine dinucleotide binding//UDP-N-acetylmuramate dehydrogenase activity//oxidoreductase activity -- -- KOG1262 FAD-binding protein DIMINUTO Cluster-8309.29775 BF_2 24.98 0.50 2396 478253990 ENN74282.1 275 2.0e-21 hypothetical protein YQE_09254, partial [Dendroctonus ponderosae]>gi|546673736|gb|ERL85292.1| hypothetical protein D910_02713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29777 BF_2 232.22 3.89 2784 642939522 XP_008190961.1 1874 9.0e-207 PREDICTED: dual specificity protein phosphatase CDC14B isoform X1 [Tribolium castaneum]>gi|642939524|ref|XP_008190966.1| PREDICTED: dual specificity protein phosphatase CDC14B isoform X1 [Tribolium castaneum] -- -- -- -- -- K06639 CDC14 cell division cycle 14 http://www.genome.jp/dbget-bin/www_bget?ko:K06639 Q6GQT0 1212 2.1e-131 Dual specificity protein phosphatase CDC14A OS=Mus musculus GN=Cdc14a PE=2 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.29778 BF_2 7.68 0.57 853 478251481 ENN71944.1 320 4.3e-27 hypothetical protein YQE_11378, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29780 BF_2 774.63 15.25 2412 642927926 XP_001814448.2 1898 1.3e-209 PREDICTED: LOW QUALITY PROTEIN: membralin [Tribolium castaneum] 642927925 XM_001814396.2 309 1.84114e-158 PREDICTED: Tribolium castaneum membralin (LOC663408), mRNA -- -- -- -- Q4ZIN3 1161 1.5e-125 Membralin OS=Homo sapiens GN=TMEM259 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2092 Uncharacterized conserved protein Cluster-8309.29781 BF_2 48.65 6.92 581 642935129 XP_008197899.1 152 8.9e-08 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29782 BF_2 1400.91 9.53 6436 642938747 XP_008199872.1 2423 4.6e-270 PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Tribolium castaneum] 41393060 NM_201427.1 39 6.12449e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1766 2.9e-195 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.29785 BF_2 1641.00 20.13 3697 189233949 XP_001815164.1 3461 0.0e+00 PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911540|ref|XP_008199465.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum]>gi|642911543|ref|XP_008199466.1| PREDICTED: striatin-interacting protein 1 isoform X1 [Tribolium castaneum] 801398844 XM_012204509.1 230 2.33549e-114 PREDICTED: Atta cephalotes striatin-interacting protein 1 (LOC105623108), mRNA -- -- -- -- Q5VSL9 2171 1.8e-242 Striatin-interacting protein 1 OS=Homo sapiens GN=STRIP1 PE=1 SV=1 PF07462//PF02428 Merozoite surface protein 1 (MSP1) C-terminus//Potato type II proteinase inhibitor family GO:0009405 pathogenesis GO:0004867 serine-type endopeptidase inhibitor activity GO:0016020 membrane KOG3680 Uncharacterized conserved protein Cluster-8309.29787 BF_2 12.13 0.34 1771 642924529 XP_008194333.1 1090 4.7e-116 PREDICTED: kinesin-like protein Klp10A [Tribolium castaneum] -- -- -- -- -- K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 P28740 768 4.2e-80 Kinesin-like protein KIF2A OS=Mus musculus GN=Kif2a PE=1 SV=2 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0246 Kinesin-like protein Cluster-8309.29789 BF_2 2731.91 64.57 2057 91088839 XP_970745.1 1383 5.7e-150 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] 642932363 XM_965652.3 444 0 PREDICTED: Tribolium castaneum RNA-binding protein lark (LOC659335), mRNA K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 914 5.7e-97 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF00098//PF08777//PF00076//PF01788//PF16367 Zinc knuckle//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PsbJ//RNA recognition motif GO:0015979 photosynthesis GO:0003723//GO:0000166//GO:0008270//GO:0003676//GO:0046872 RNA binding//nucleotide binding//zinc ion binding//nucleic acid binding//metal ion binding GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-8309.29790 BF_2 1121.45 46.46 1297 478256475 ENN76660.1 1125 3.0e-120 hypothetical protein YQE_06839, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C854 499 4.7e-49 Myelin expression factor 2 OS=Mus musculus GN=Myef2 PE=1 SV=1 PF03468//PF00076 XS domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0031047 gene silencing by RNA GO:0003676 nucleic acid binding -- -- KOG4212 RNA-binding protein hnRNP-M Cluster-8309.29791 BF_2 20.01 0.32 2913 -- -- -- -- -- 462391749 APGK01018334.1 54 1.26351e-16 Dendroctonus ponderosae Seq01018344, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29792 BF_2 61.58 1.24 2364 91081249 XP_975650.1 377 3.0e-33 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q5XIU9 280 2.2e-23 Membrane-associated progesterone receptor component 2 OS=Rattus norvegicus GN=Pgrmc2 PE=2 SV=1 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.29793 BF_2 35.00 66.94 287 108794573 ABG20822.1 339 9.1e-30 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 273 1.7e-23 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.29795 BF_2 285.82 11.85 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.29797 BF_2 267.55 2.32 5107 91078490 XP_968588.1 2030 1.3e-224 PREDICTED: COP9 signalosome complex subunit 1 [Tribolium castaneum]>gi|270004016|gb|EFA00464.1| hypothetical protein TcasGA2_TC003322 [Tribolium castaneum] 642915516 XM_963495.3 360 0 PREDICTED: Tribolium castaneum COP9 signalosome complex subunit 1 (LOC657006), mRNA K12175 GPS1, COPS1, CSN1 COP9 signalosome complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12175 Q99LD4 1580 8.4e-174 COP9 signalosome complex subunit 1 OS=Mus musculus GN=Gps1 PE=1 SV=1 PF00515//PF01399//PF13414 Tetratricopeptide repeat//PCI domain//TPR repeat -- -- GO:0005515 protein binding -- -- KOG0686 COP9 signalosome, subunit CSN1 Cluster-8309.29799 BF_2 2076.00 15.31 5958 642932582 XP_008196911.1 6827 0.0e+00 PREDICTED: transcription elongation factor SPT6 isoform X1 [Tribolium castaneum]>gi|270011547|gb|EFA07995.1| hypothetical protein TcasGA2_TC005584 [Tribolium castaneum] 571562785 XM_006570424.1 121 1.47915e-53 PREDICTED: Apis mellifera transcription elongation factor SPT6-like (LOC410274), mRNA K11292 SUPT6H, SPT6 transcription elongation factor SPT6 http://www.genome.jp/dbget-bin/www_bget?ko:K11292 Q9W420 4243 0.0e+00 Transcription elongation factor SPT6 OS=Drosophila melanogaster GN=Spt6 PE=1 SV=1 PF00575//PF14641 S1 RNA binding domain//Helix-turn-helix DNA-binding domain of SPT6 GO:0006357//GO:0032784 regulation of transcription from RNA polymerase II promoter//regulation of DNA-templated transcription, elongation GO:0016788//GO:0003723//GO:0003676//GO:0003677 hydrolase activity, acting on ester bonds//RNA binding//nucleic acid binding//DNA binding -- -- KOG1856 Transcription elongation factor SPT6 Cluster-8309.29800 BF_2 7.87 0.39 1131 642922682 XP_008193278.1 379 8.3e-34 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X10 [Tribolium castaneum] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 Q9JI18 301 3.8e-26 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29803 BF_2 25.62 0.83 1581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.29805 BF_2 237.00 7.43 1622 478251321 ENN71789.1 1307 2.9e-141 hypothetical protein YQE_11523, partial [Dendroctonus ponderosae]>gi|546673509|gb|ERL85095.1| hypothetical protein D910_02517 [Dendroctonus ponderosae] -- -- -- -- -- K09521 DNAJC1 DnaJ homolog subfamily C member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09521 Q61712 496 1.3e-48 DnaJ homolog subfamily C member 1 OS=Mus musculus GN=Dnajc1 PE=1 SV=1 PF07074 Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006613 cotranslational protein targeting to membrane -- -- GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG0724 Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains Cluster-8309.29806 BF_2 600.22 14.67 1999 91076860 XP_974922.1 944 4.5e-99 PREDICTED: zinc finger protein Noc [Tribolium castaneum]>gi|270002778|gb|EEZ99225.1| no ocelli [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24423 499 7.3e-49 Zinc finger protein Noc OS=Drosophila melanogaster GN=noc PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.29808 BF_2 129.59 1.30 4468 642919809 XP_008192077.1 4552 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X2 [Tribolium castaneum] 642919808 XM_008193855.1 741 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X2, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1839 6.8e-204 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF05445//PF07714//PF00069//PF06293 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.29809 BF_2 3.00 18.84 246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29810 BF_2 47.14 1.30 1800 642911285 XP_008199356.1 1588 8.5e-174 PREDICTED: tyrosine-protein kinase CSK isoform X1 [Tribolium castaneum] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 P41239 1015 9.7e-109 Tyrosine-protein kinase CSK OS=Gallus gallus GN=CSK PE=2 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.29811 BF_2 45.27 0.50 4086 91077926 XP_974115.1 1002 1.7e-105 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] 689542246 LL999048.1 56 1.375e-17 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_scaffold0000001 -- -- -- -- Q9X248 335 1.6e-29 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=fabG PE=3 SV=1 PF12242//PF01370//PF05889//PF07684//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//NOTCH protein//short chain dehydrogenase GO:0030154//GO:0055114//GO:0007275//GO:0008152//GO:0007219 cell differentiation//oxidation-reduction process//multicellular organismal development//metabolic process//Notch signaling pathway GO:0000166//GO:0016740//GO:0050662//GO:0003824//GO:0016491 nucleotide binding//transferase activity//coenzyme binding//catalytic activity//oxidoreductase activity GO:0016021 integral component of membrane -- -- Cluster-8309.29812 BF_2 776.55 18.54 2039 91081755 XP_972918.1 2214 2.5e-246 PREDICTED: translation initiation factor eIF-2B subunit epsilon isoform X1 [Tribolium castaneum]>gi|270006269|gb|EFA02717.1| hypothetical protein TcasGA2_TC008441 [Tribolium castaneum] -- -- -- -- -- K03240 EIF2B5 translation initiation factor eIF-2B subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K03240 Q13144 922 6.7e-98 Translation initiation factor eIF-2B subunit epsilon OS=Homo sapiens GN=EIF2B5 PE=1 SV=3 PF02020//PF07959//PF00483 eIF4-gamma/eIF5/eIF2-epsilon//L-fucokinase//Nucleotidyl transferase GO:0016070//GO:0009058 RNA metabolic process//biosynthetic process GO:0016772//GO:0016740//GO:0016779//GO:0005515 transferase activity, transferring phosphorus-containing groups//transferase activity//nucleotidyltransferase activity//protein binding -- -- KOG1461 Translation initiation factor 2B, epsilon subunit (eIF-2Bepsilon/GCD6) Cluster-8309.29814 BF_2 46.94 0.91 2436 189238186 XP_966734.2 1514 4.4e-165 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 827552986 XM_012692757.1 245 7.02835e-123 PREDICTED: Bombyx mori coronin-6 (LOC101745724), transcript variant X2, mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q9ULV4 983 6.7e-105 Coronin-1C OS=Homo sapiens GN=CORO1C PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.29815 BF_2 82.00 3.54 1257 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29816 BF_2 103.18 4.13 1331 91087465 XP_967435.1 911 2.0e-95 PREDICTED: uncharacterized protein LOC655780 [Tribolium castaneum]>gi|270010660|gb|EFA07108.1| hypothetical protein TcasGA2_TC010098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29819 BF_2 3.32 0.39 644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29822 BF_2 64.47 0.58 4946 642928077 XP_008200146.1 1753 1.7e-192 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 Q9QWW1 681 1.4e-69 Homer protein homolog 2 OS=Mus musculus GN=Homer2 PE=1 SV=1 PF16716//PF06703//PF13851//PF06810//PF10473//PF07989//PF03938//PF07926//PF00038//PF16940//PF15898 Bone marrow stromal antigen 2//Microsomal signal peptidase 25 kDa subunit (SPC25)//Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Chloroplast envelope transporter//cGMP-dependent protein kinase interacting domain GO:0051607//GO:0006465//GO:0048870//GO:0006606 defense response to virus//signal peptide processing//cell motility//protein import into nucleus GO:0042803//GO:0051082//GO:0019901//GO:0008233//GO:0005198//GO:0045502//GO:0008134 protein homodimerization activity//unfolded protein binding//protein kinase binding//peptidase activity//structural molecule activity//dynein binding//transcription factor binding GO:0030286//GO:0005667//GO:0009507//GO:0005787//GO:0016021//GO:0005815//GO:0031514//GO:0005882 dynein complex//transcription factor complex//chloroplast//signal peptidase complex//integral component of membrane//microtubule organizing center//motile cilium//intermediate filament -- -- Cluster-8309.29824 BF_2 45.79 0.88 2472 642916843 XP_008199526.1 668 5.6e-67 PREDICTED: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [Tribolium castaneum]>gi|270003073|gb|EEZ99520.1| hypothetical protein TcasGA2_TC000101 [Tribolium castaneum] -- -- -- -- -- K01482 DDAH, ddaH dimethylargininase http://www.genome.jp/dbget-bin/www_bget?ko:K01482 O08557 304 3.7e-26 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Rattus norvegicus GN=Ddah1 PE=1 SV=3 -- -- GO:0006807 nitrogen compound metabolic process GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0005737 cytoplasm -- -- Cluster-8309.29826 BF_2 39.00 0.77 2393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00695 Major surface antigen from hepadnavirus GO:0016032 viral process -- -- -- -- -- -- Cluster-8309.29828 BF_2 2.00 59.81 208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29829 BF_2 18.95 0.60 1608 642935990 XP_008198259.1 455 1.8e-42 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 390 2.6e-36 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.29830 BF_2 108.00 9.80 748 478250947 ENN71431.1 331 2.0e-28 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MHZ9 133 7.6e-07 Collectin-46 OS=Bos taurus GN=CL46 PE=2 SV=1 PF04166//PF00211 Pyridoxal phosphate biosynthetic protein PdxA//Adenylate and Guanylate cyclase catalytic domain GO:0008615//GO:0035556//GO:0055114//GO:0009190//GO:0042816 pyridoxine biosynthetic process//intracellular signal transduction//oxidation-reduction process//cyclic nucleotide biosynthetic process//vitamin B6 metabolic process GO:0050570//GO:0016849//GO:0051287 4-hydroxythreonine-4-phosphate dehydrogenase activity//phosphorus-oxygen lyase activity//NAD binding -- -- -- -- Cluster-8309.29831 BF_2 333.00 6.12 2565 189239691 XP_974700.2 1611 2.6e-176 PREDICTED: probable phenylalanine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270010728|gb|EFA07176.1| hypothetical protein TcasGA2_TC010176 [Tribolium castaneum] -- -- -- -- -- K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 O16129 1377 1.5e-150 Probable phenylalanine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-phe PE=2 SV=3 PF01409//PF00152//PF03147 tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N)//Ferredoxin-fold anticodon binding domain GO:0043039//GO:0006571//GO:0000162//GO:0008033//GO:0009094//GO:0006418//GO:0006432 tRNA aminoacylation//tyrosine biosynthetic process//tryptophan biosynthetic process//tRNA processing//L-phenylalanine biosynthetic process//tRNA aminoacylation for protein translation//phenylalanyl-tRNA aminoacylation GO:0004812//GO:0000287//GO:0000166//GO:0004826//GO:0000049//GO:0005524 aminoacyl-tRNA ligase activity//magnesium ion binding//nucleotide binding//phenylalanine-tRNA ligase activity//tRNA binding//ATP binding GO:0005737//GO:0009328 cytoplasm//phenylalanine-tRNA ligase complex KOG2783 Phenylalanyl-tRNA synthetase Cluster-8309.29832 BF_2 70.00 1.83 1890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29833 BF_2 412.86 2.76 6540 91085969 XP_971641.1 2307 1.3e-256 PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927542|ref|XP_008195309.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927544|ref|XP_008195310.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927547|ref|XP_008195311.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum] -- -- -- -- -- K09239 HIVEP human immunodeficiency virus type I enhancer-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09239 A2A884 339 8.6e-30 Transcription factor HIVEP3 OS=Mus musculus GN=Hivep3 PE=1 SV=1 PF00651//PF00320//PF13465//PF00096 BTB/POZ domain//GATA zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0005515//GO:0003700//GO:0043565//GO:0008270 metal ion binding//protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667 transcription factor complex KOG1721 FOG: Zn-finger Cluster-8309.29834 BF_2 237.12 1.70 6125 91085969 XP_971641.1 2307 1.2e-256 PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927542|ref|XP_008195309.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927544|ref|XP_008195310.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum]>gi|642927547|ref|XP_008195311.1| PREDICTED: uncharacterized protein LOC660305 [Tribolium castaneum] -- -- -- -- -- K09239 HIVEP human immunodeficiency virus type I enhancer-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09239 A2A884 339 8.0e-30 Transcription factor HIVEP3 OS=Mus musculus GN=Hivep3 PE=1 SV=1 PF00096//PF13465//PF00651 Zinc finger, C2H2 type//Zinc-finger double domain//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.29837 BF_2 23.29 0.73 1617 642928886 XP_008195603.1 400 4.3e-36 PREDICTED: junctional adhesion molecule B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29838 BF_2 332.02 8.23 1974 332375851 AEE63066.1 1156 1.2e-123 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 P17439 819 5.7e-86 Glucosylceramidase OS=Mus musculus GN=Gba PE=1 SV=1 PF02806//PF02055 Alpha amylase, C-terminal all-beta domain//O-Glycosyl hydrolase family 30 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348//GO:0043169//GO:0003824 glucosylceramidase activity//cation binding//catalytic activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.29842 BF_2 56.00 1.91 1512 332374088 AEE62185.1 881 6.8e-92 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CAK1 377 7.8e-35 Putative transferase CAF17 homolog, mitochondrial OS=Mus musculus GN=Iba57 PE=1 SV=1 PF09128//PF04053 Regulator of G protein signalling-like domain//Coatomer WD associated region GO:0043087//GO:0016192//GO:0006886 regulation of GTPase activity//vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005089 structural molecule activity//Rho guanyl-nucleotide exchange factor activity GO:0030117//GO:0005737 membrane coat//cytoplasm KOG2929 Transcription factor, component of CCR4 transcriptional complex Cluster-8309.29844 BF_2 291.18 4.36 3083 642929332 XP_973791.2 2166 1.4e-240 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum]>gi|270010511|gb|EFA06959.1| hypothetical protein TcasGA2_TC009917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.29847 BF_2 636.08 13.35 2280 91084407 XP_967001.1 633 5.9e-63 PREDICTED: uncharacterized protein LOC655368 [Tribolium castaneum]>gi|270008706|gb|EFA05154.1| hypothetical protein TcasGA2_TC015272 [Tribolium castaneum] 797056887 HG313992.1 77 1.61571e-29 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 14 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29848 BF_2 58.00 3.17 1053 642911178 XP_008200613.1 269 4.4e-21 PREDICTED: DNA-directed RNA polymerase II subunit GRINL1A [Tribolium castaneum]>gi|270014682|gb|EFA11130.1| hypothetical protein TcasGA2_TC004731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15328//PF00527 Putative GRINL1B complex locus protein 2//E7 protein, Early protein GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0016591 transcription factor complex//DNA-directed RNA polymerase II, holoenzyme -- -- Cluster-8309.29850 BF_2 49.99 11.36 471 642930498 XP_008196429.1 461 1.1e-43 PREDICTED: CLIP-associating protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q9NBD7 274 2.1e-23 CLIP-associating protein OS=Drosophila melanogaster GN=chb PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29852 BF_2 350.12 11.14 1602 642925526 XP_008194587.1 1323 4.0e-143 PREDICTED: probable low-specificity L-threonine aldolase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 727 2.1e-75 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF01053//PF01212//PF00155 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG1368 Threonine aldolase Cluster-8309.29855 BF_2 131.29 0.99 5819 478257810 ENN77953.1 2106 2.4e-233 hypothetical protein YQE_05630, partial [Dendroctonus ponderosae] -- -- -- -- -- K14833 NOC2 nucleolar complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14833 Q9VIF0 1452 6.7e-159 Nucleolar complex protein 2 homolog OS=Drosophila melanogaster GN=CG9246 PE=1 SV=1 PF07690//PF00083//PF01292 Major Facilitator Superfamily//Sugar (and other) transporter//Prokaryotic cytochrome b561 GO:0006118//GO:0055085 obsolete electron transport//transmembrane transport GO:0009055//GO:0022857 electron carrier activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG2256 Predicted protein involved in nuclear export of pre-ribosomes Cluster-8309.29857 BF_2 105.49 0.58 7897 642910328 XP_008200285.1 9610 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270014917|gb|EFA11365.1| hypothetical protein TcasGA2_TC011522 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 2979 0.0e+00 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF00975//PF00106//PF00107//PF00108//PF08545//PF02052 Thioesterase domain//short chain dehydrogenase//Zinc-binding dehydrogenase//Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Gallidermin GO:0006633//GO:0008152//GO:0042742//GO:0042967//GO:0055114//GO:0009058 fatty acid biosynthetic process//metabolic process//defense response to bacterium//acyl-carrier-protein biosynthetic process//oxidation-reduction process//biosynthetic process GO:0016788//GO:0004319//GO:0016491//GO:0016295//GO:0004320//GO:0004316//GO:0016747//GO:0004314//GO:0004313//GO:0004317//GO:0004315//GO:0008270//GO:0000166//GO:0016296 hydrolase activity, acting on ester bonds//enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity//oxidoreductase activity//myristoyl-[acyl-carrier-protein] hydrolase activity//oleoyl-[acyl-carrier-protein] hydrolase activity//3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity//transferase activity, transferring acyl groups other than amino-acyl groups//[acyl-carrier-protein] S-malonyltransferase activity//[acyl-carrier-protein] S-acetyltransferase activity//3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity//3-oxoacyl-[acyl-carrier-protein] synthase activity//zinc ion binding//nucleotide binding//palmitoyl-[acyl-carrier-protein] hydrolase activity GO:0005835//GO:0005576 fatty acid synthase complex//extracellular region KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.29859 BF_2 207.92 15.10 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29860 BF_2 21.45 0.59 1810 270007657 EFA04105.1 866 4.5e-90 hypothetical protein TcasGA2_TC014342 [Tribolium castaneum] -- -- -- -- -- K11406 HDAC4_5 histone deacetylase 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11406 Q9Z2V6 180 6.5e-12 Histone deacetylase 5 OS=Mus musculus GN=Hdac5 PE=1 SV=2 PF12899//PF00481//PF04216 Alkaline and neutral invertase//Protein phosphatase 2C//Protein involved in formate dehydrogenase formation -- -- GO:0033926//GO:0003824 glycopeptide alpha-N-acetylgalactosaminidase activity//catalytic activity GO:0005737 cytoplasm -- -- Cluster-8309.29861 BF_2 1653.55 23.14 3276 270007657 EFA04105.1 3170 0.0e+00 hypothetical protein TcasGA2_TC014342 [Tribolium castaneum] 642923488 XM_962332.3 720 0 PREDICTED: Tribolium castaneum histone deacetylase 7 (LOC655770), mRNA K11406 HDAC4_5 histone deacetylase 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11406 Q9Z2V6 1410 2.8e-154 Histone deacetylase 5 OS=Mus musculus GN=Hdac5 PE=1 SV=2 PF12899//PF00481 Alkaline and neutral invertase//Protein phosphatase 2C -- -- GO:0033926//GO:0003824 glycopeptide alpha-N-acetylgalactosaminidase activity//catalytic activity -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.29862 BF_2 2934.73 18.67 6864 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 5.6e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF01480//PF03015//PF01370//PF00076//PF00309//PF01400//PF01429//PF00642//PF01073 PWI domain//Male sterility protein//NAD dependent epimerase/dehydratase family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sigma-54 factor, Activator interacting domain (AID)//Astacin (Peptidase family M12A)//Methyl-CpG binding domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0006206//GO:0006508//GO:0006352//GO:0006351//GO:0006397//GO:0008210//GO:0006144//GO:0006355//GO:0008207//GO:0055114//GO:0006694//GO:0008209 pyrimidine nucleobase metabolic process//proteolysis//DNA-templated transcription, initiation//transcription, DNA-templated//mRNA processing//estrogen metabolic process//purine nucleobase metabolic process//regulation of transcription, DNA-templated//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003676//GO:0016987//GO:0046872//GO:0003824//GO:0003677//GO:0080019//GO:0003700//GO:0004222//GO:0003854//GO:0003899//GO:0050662//GO:0016616 nucleic acid binding//sigma factor activity//metal ion binding//catalytic activity//DNA binding//fatty-acyl-CoA reductase (alcohol-forming) activity//transcription factor activity, sequence-specific DNA binding//metalloendopeptidase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//DNA-directed RNA polymerase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005634//GO:0005667//GO:0005730 nucleus//transcription factor complex//nucleolus KOG1221 Acyl-CoA reductase Cluster-8309.29863 BF_2 227.83 1.44 6920 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 5.7e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF00076//PF01429//PF01400//PF01073//PF00642//PF03015//PF01480//PF01370 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Methyl-CpG binding domain//Astacin (Peptidase family M12A)//3-beta hydroxysteroid dehydrogenase/isomerase family//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Male sterility protein//PWI domain//NAD dependent epimerase/dehydratase family GO:0006508//GO:0008210//GO:0006397//GO:0008209//GO:0006694//GO:0055114//GO:0008207 proteolysis//estrogen metabolic process//mRNA processing//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0046872//GO:0003676//GO:0003677//GO:0003824//GO:0080019//GO:0016616//GO:0050662//GO:0003854//GO:0004222 metal ion binding//nucleic acid binding//DNA binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//metalloendopeptidase activity GO:0005634 nucleus KOG1221 Acyl-CoA reductase Cluster-8309.29864 BF_2 16.03 1.49 738 157138609 XP_001664277.1 519 3.1e-50 AAEL003891-PA [Aedes aegypti]>gi|108880565|gb|EAT44790.1| AAEL003891-PA [Aedes aegypti] -- -- -- -- -- K06515 SLC44A1, CDW92 solute carrier family 44 (choline transporter-like protein), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06515 Q54I48 333 4.8e-30 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.29865 BF_2 277.00 7.01 1941 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29866 BF_2 362.60 4.18 3912 642922441 XP_008193170.1 2349 1.1e-261 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922836 XM_008195125.1 330 6.36018e-170 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X1, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1931 1.3e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF00479//PF02781//PF00180//PF10538 Glucose-6-phosphate dehydrogenase, NAD binding domain//Glucose-6-phosphate dehydrogenase, C-terminal domain//Isocitrate/isopropylmalate dehydrogenase//Immunoreceptor tyrosine-based activation motif GO:0006006//GO:0006749//GO:0006098//GO:0007165//GO:0055114 glucose metabolic process//glutathione metabolic process//pentose-phosphate shunt//signal transduction//oxidation-reduction process GO:0050661//GO:0016616//GO:0004345 NADP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.29867 BF_2 68.36 0.50 6046 546675274 ERL86510.1 3789 0.0e+00 hypothetical protein D910_03914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR5 714 2.6e-73 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 PF00616//PF02881 GTPase-activator protein for Ras-like GTPase//SRP54-type protein, helical bundle domain GO:0043087//GO:0006614 regulation of GTPase activity//SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.29869 BF_2 9.00 1.03 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29871 BF_2 75.76 1.68 2170 642917912 XP_008191379.1 1038 6.1e-110 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 569 6.1e-57 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.29872 BF_2 34.00 1.72 1116 642928708 XP_008199749.1 260 5.1e-20 PREDICTED: uncharacterized protein LOC662585 isoform X11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29873 BF_2 67.00 3.58 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29876 BF_2 59.21 0.50 5209 642912009 XP_008199058.1 1160 1.0e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X1 [Tribolium castaneum]>gi|270014484|gb|EFA10932.1| hypothetical protein TcasGA2_TC001759 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29877 BF_2 110.56 1.60 3183 91092214 XP_969938.1 2127 4.7e-236 PREDICTED: uncharacterized protein LOC658457 [Tribolium castaneum]>gi|270014434|gb|EFA10882.1| hypothetical protein TcasGA2_TC001706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48613 198 9.3e-14 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.29878 BF_2 6.75 1.27 509 357606614 EHJ65136.1 469 1.4e-44 hypothetical protein KGM_05509 [Danaus plexippus] 795059903 XM_012017609.1 129 4.24997e-59 PREDICTED: Vollenhovia emeryi uncharacterized LOC105564872 (LOC105564872), mRNA -- -- -- -- A1ZA47 426 5.4e-41 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.29879 BF_2 17.88 0.59 1561 642913680 XP_008201115.1 852 1.6e-88 PREDICTED: protein amalgam-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29882 BF_2 196.00 6.02 1649 546681591 ERL91655.1 1100 3.0e-117 hypothetical protein D910_08983, partial [Dendroctonus ponderosae] 642917222 XM_963027.2 298 1.62865e-152 PREDICTED: Tribolium castaneum splicing factor 3B subunit 4 (LOC656501), mRNA K12831 SF3B4, SAP49 splicing factor 3B subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12831 Q15427 1030 1.6e-110 Splicing factor 3B subunit 4 OS=Homo sapiens GN=SF3B4 PE=1 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0131 Splicing factor 3b, subunit 4 Cluster-8309.29884 BF_2 1886.66 50.60 1847 478251864 ENN72303.1 1127 2.5e-120 hypothetical protein YQE_11046, partial [Dendroctonus ponderosae]>gi|546674377|gb|ERL85764.1| hypothetical protein D910_03179 [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 1.2e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.29887 BF_2 13181.61 202.44 3011 478250663 ENN71155.1 1488 5.6e-162 hypothetical protein YQE_12086, partial [Dendroctonus ponderosae]>gi|546677247|gb|ERL88116.1| hypothetical protein D910_05505 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 801 1.1e-83 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF00487//PF08320 Fatty acid desaturase//PIG-X / PBN1 GO:0006506//GO:0006629 GPI anchor biosynthetic process//lipid metabolic process -- -- GO:0005789 endoplasmic reticulum membrane KOG0537 Cytochrome b5 Cluster-8309.29888 BF_2 245.60 1.91 5657 642933837 XP_008197529.1 1903 7.9e-210 PREDICTED: epsin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 1185 5.9e-128 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF02376//PF05557 CUT domain//Mitotic checkpoint protein GO:0007094 mitotic spindle assembly checkpoint GO:0003677 DNA binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-8309.29891 BF_2 409.74 6.33 2995 642925692 XP_008194672.1 1905 2.5e-210 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 4.51149e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q9NP58 1393 2.4e-152 ATP-binding cassette sub-family B member 6, mitochondrial OS=Homo sapiens GN=ABCB6 PE=1 SV=1 PF00503//PF00005//PF03193//PF06414//PF00004//PF02224//PF01583//PF07728//PF00664//PF13304//PF01926 G-protein alpha subunit//ABC transporter//Protein of unknown function, DUF258//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0007165//GO:0055085//GO:0006139//GO:0006810//GO:0006200//GO:0007186//GO:0006144//GO:0000103//GO:0006206 signal transduction//transmembrane transport//nucleobase-containing compound metabolic process//transport//obsolete ATP catabolic process//G-protein coupled receptor signaling pathway//purine nucleobase metabolic process//sulfate assimilation//pyrimidine nucleobase metabolic process GO:0005524//GO:0031683//GO:0003924//GO:0004127//GO:0019001//GO:0016887//GO:0016301//GO:0042626//GO:0004020//GO:0005525//GO:0004871 ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//cytidylate kinase activity//guanyl nucleotide binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//adenylylsulfate kinase activity//GTP binding//signal transducer activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29892 BF_2 1748.76 67.37 1373 332374126 AEE62204.1 1134 2.9e-121 unknown [Dendroctonus ponderosae]>gi|478256630|gb|ENN76812.1| hypothetical protein YQE_06653, partial [Dendroctonus ponderosae]>gi|546685174|gb|ERL94701.1| hypothetical protein D910_11975 [Dendroctonus ponderosae] -- -- -- -- -- K10258 TER, TSC13, CER10 very-long-chain enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10258 Q9N5Y2 847 2.2e-89 Probable very-long-chain enoyl-CoA reductase art-1 OS=Caenorhabditis elegans GN=art-1 PE=3 SV=1 PF00240//PF02544 Ubiquitin family//3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627//GO:0005515 oxidoreductase activity, acting on the CH-CH group of donors//protein binding GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1639 Steroid reductase required for elongation of the very long chain fatty acids Cluster-8309.29893 BF_2 161.92 7.99 1135 642925692 XP_008194672.1 736 3.3e-75 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] -- -- -- -- -- K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 561 2.7e-56 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF00005 ABC transporter GO:0006200//GO:0006810//GO:0055085 obsolete ATP catabolic process//transport//transmembrane transport GO:0042626//GO:0005524//GO:0016887 ATPase activity, coupled to transmembrane movement of substances//ATP binding//ATPase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29894 BF_2 821.83 11.50 3277 642925692 XP_008194672.1 3452 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 4.94144e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 2168 3.5e-242 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF00005//PF03193//PF06414//PF07728//PF01583//PF00664//PF01926//PF13304//PF00004//PF02224 ABC transporter//Protein of unknown function, DUF258//Zeta toxin//AAA domain (dynein-related subfamily)//Adenylylsulphate kinase//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase GO:0006206//GO:0000103//GO:0006144//GO:0055085//GO:0006139//GO:0006200//GO:0006810 pyrimidine nucleobase metabolic process//sulfate assimilation//purine nucleobase metabolic process//transmembrane transport//nucleobase-containing compound metabolic process//obsolete ATP catabolic process//transport GO:0005525//GO:0004020//GO:0016301//GO:0016887//GO:0004127//GO:0042626//GO:0005524//GO:0003924 GTP binding//adenylylsulfate kinase activity//kinase activity//ATPase activity//cytidylate kinase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29895 BF_2 42.14 0.58 3331 642925692 XP_008194672.1 3452 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 5.02378e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 2168 3.6e-242 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF02224//PF00004//PF01583//PF07728//PF01926//PF13304//PF00664//PF03193//PF00005//PF06414 Cytidylate kinase//ATPase family associated with various cellular activities (AAA)//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter//Zeta toxin GO:0006144//GO:0000103//GO:0006206//GO:0006810//GO:0006139//GO:0006200//GO:0055085 purine nucleobase metabolic process//sulfate assimilation//pyrimidine nucleobase metabolic process//transport//nucleobase-containing compound metabolic process//obsolete ATP catabolic process//transmembrane transport GO:0004020//GO:0005525//GO:0003924//GO:0005524//GO:0042626//GO:0016301//GO:0004127//GO:0016887 adenylylsulfate kinase activity//GTP binding//GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//kinase activity//cytidylate kinase activity//ATPase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29896 BF_2 1501.37 23.74 2933 642925692 XP_008194672.1 3452 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 6, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008646|gb|EFA05094.1| hypothetical protein TcasGA2_TC015192 [Tribolium castaneum] 42764716 AY439686.1 98 4.41696e-41 Armigeres subalbatus ASAP ID: 43930 ATP-binding cassette transporter mRNA sequence K05663 ABC.ATM mitochondrial ABC transporter ATM http://www.genome.jp/dbget-bin/www_bget?ko:K05663 Q08D64 2168 3.2e-242 ATP-binding cassette sub-family B member 6, mitochondrial OS=Xenopus tropicalis GN=abcb6 PE=2 SV=1 PF00664//PF13304//PF01926//PF01583//PF07728//PF00004//PF02224//PF06414//PF00005//PF03193 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Cytidylate kinase//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0006139//GO:0006200//GO:0055085//GO:0006206//GO:0006144//GO:0000103 transport//nucleobase-containing compound metabolic process//obsolete ATP catabolic process//transmembrane transport//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//sulfate assimilation GO:0042626//GO:0016887//GO:0004127//GO:0016301//GO:0003924//GO:0005524//GO:0005525//GO:0004020 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//cytidylate kinase activity//kinase activity//GTPase activity//ATP binding//GTP binding//adenylylsulfate kinase activity GO:0016021 integral component of membrane KOG0056 Heavy metal exporter HMT1, ABC superfamily Cluster-8309.29898 BF_2 204.00 10.35 1112 332372905 AEE61594.1 639 5.8e-64 unknown [Dendroctonus ponderosae]>gi|546674532|gb|ERL85892.1| hypothetical protein D910_03307 [Dendroctonus ponderosae] -- -- -- -- -- K17412 MRPS34 small subunit ribosomal protein S34 http://www.genome.jp/dbget-bin/www_bget?ko:K17412 P82929 157 1.9e-09 28S ribosomal protein S34, mitochondrial OS=Bos taurus GN=MRPS34 PE=1 SV=2 PF16053 Mitochondrial 28S ribosomal protein S34 GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0005739 ribosome//mitochondrion -- -- Cluster-8309.29900 BF_2 1181.00 5.73 8903 642937796 XP_008200304.1 11335 0.0e+00 PREDICTED: notch isoform X1 [Tribolium castaneum] 665794822 XM_008546906.1 396 0 PREDICTED: Microplitis demolitor neurogenic locus Notch protein (LOC103569561), transcript variant X2, mRNA K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 P07207 7969 0.0e+00 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF00023//PF07684//PF13606//PF00008//PF06816//PF07645 Ankyrin repeat//NOTCH protein//Ankyrin repeat//EGF-like domain//NOTCH protein//Calcium-binding EGF domain GO:0007275//GO:0030154//GO:0007219 multicellular organismal development//cell differentiation//Notch signaling pathway GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.29901 BF_2 247.00 5.59 2136 91085389 XP_966562.1 1515 2.9e-165 PREDICTED: solute carrier family 35 member G1 [Tribolium castaneum]>gi|270009150|gb|EFA05598.1| hypothetical protein TcasGA2_TC015802 [Tribolium castaneum] 815768624 XM_012376721.1 50 1.54451e-14 PREDICTED: Linepithema humile solute carrier family 35 member G1-like (LOC105677844), mRNA -- -- -- -- Q2M3R5 586 6.4e-59 Solute carrier family 35 member G1 OS=Homo sapiens GN=SLC35G1 PE=1 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4510 Permease of the drug/metabolite transporter (DMT) superfamily Cluster-8309.29902 BF_2 42.11 1.33 1612 332374466 AEE62374.1 463 2.1e-43 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01310 CTRB chymotrypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01310 O97398 331 1.8e-29 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.29903 BF_2 119.00 3.25 1820 642928295 XP_008195522.1 628 1.8e-62 PREDICTED: calponin homology domain-containing protein DDB_G0272472-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29904 BF_2 10.45 0.36 1490 546680624 ERL90862.1 233 9.3e-17 hypothetical protein D910_08207 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF01663//PF00539 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Transactivating regulatory protein (Tat) GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0008484//GO:0003824 transcription factor activity, sequence-specific DNA binding//sulfuric ester hydrolase activity//catalytic activity GO:0005667//GO:0042025 transcription factor complex//host cell nucleus -- -- Cluster-8309.29907 BF_2 369.00 42.31 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29908 BF_2 145.85 2.43 2799 478263484 ENN81839.1 260 1.3e-19 hypothetical protein YQE_01778, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29909 BF_2 175.12 13.98 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29910 BF_2 41.50 0.42 4385 642926721 XP_008194985.1 1671 4.9e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.2e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.29912 BF_2 68.29 1.87 1814 642928919 XP_008195616.1 1164 1.3e-124 PREDICTED: beclin-1-like protein [Tribolium castaneum] 831317244 XM_012835846.1 40 4.73707e-09 PREDICTED: Clupea harengus beclin 1, autophagy related (becn1), transcript variant X2, mRNA K08334 BECN1, VPS30, ATG6 beclin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08334 Q9VCE1 897 4.7e-95 Beclin-1-like protein OS=Drosophila melanogaster GN=Atg6 PE=2 SV=1 PF04420//PF04111//PF07851//PF06156 CHD5-like protein//Autophagy protein Apg6//TMPIT-like protein//Protein of unknown function (DUF972) GO:0006914//GO:0071816//GO:0006260 autophagy//tail-anchored membrane protein insertion into ER membrane//DNA replication -- -- GO:0016021 integral component of membrane KOG2751 Beclin-like protein Cluster-8309.29917 BF_2 8.62 0.32 1406 646682520 KDR02319.1 404 1.3e-36 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] -- -- -- -- -- K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 O88831 191 2.7e-13 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Rattus norvegicus GN=Camkk2 PE=1 SV=1 PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.29918 BF_2 277.92 6.20 2162 646682520 KDR02319.1 1568 2.1e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.50775e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.0e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00937//PF07714//PF00069 Coronavirus nucleocapsid protein//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.29919 BF_2 1016.19 12.21 3770 270014920 EFA11368.1 3829 0.0e+00 hypothetical protein TcasGA2_TC011526 [Tribolium castaneum] 701357390 XM_010007485.1 90 1.59413e-36 PREDICTED: Chaetura pelagica ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), mRNA K01537 E3.6.3.8 Ca2+-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01537 Q80XR2 2536 8.7e-285 Calcium-transporting ATPase type 2C member 1 OS=Mus musculus GN=Atp2c1 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.29921 BF_2 748.14 7.62 4394 642935654 XP_008198101.1 3404 0.0e+00 PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935656|ref|XP_008198102.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935658|ref|XP_008198103.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum] 817215019 XM_012428261.1 140 2.98394e-64 PREDICTED: Orussus abietinus uncharacterized LOC105701487 (LOC105701487), mRNA K07817 PTPRN receptor-type tyrosine-protein phosphatase N http://www.genome.jp/dbget-bin/www_bget?ko:K07817 O02695 1329 9.2e-145 Receptor-type tyrosine-protein phosphatase N2 OS=Macaca nemestrina GN=PTPRN2 PE=2 SV=1 PF00782//PF00102//PF10590 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region GO:0006570//GO:0006470//GO:0055114 tyrosine metabolic process//protein dephosphorylation//oxidation-reduction process GO:0004725//GO:0016638//GO:0008138 protein tyrosine phosphatase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//protein tyrosine/serine/threonine phosphatase activity -- -- KOG0793 Protein tyrosine phosphatase Cluster-8309.29922 BF_2 5.00 7.15 300 -- -- -- -- -- 642935657 XM_008199881.1 66 2.50494e-24 PREDICTED: Tribolium castaneum receptor-type tyrosine-protein phosphatase N2 (LOC663427), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29923 BF_2 806.93 7.22 4963 642917633 XP_008193409.1 5050 0.0e+00 PREDICTED: DNA topoisomerase 2 [Tribolium castaneum] 158299571 XM_319665.4 602 0 Anopheles gambiae str. PEST AGAP008917-PA (AgaP_AGAP008917) mRNA, partial cds K03164 TOP2 DNA topoisomerase II http://www.genome.jp/dbget-bin/www_bget?ko:K03164 O16140 4530 0.0e+00 DNA topoisomerase 2 OS=Bombyx mori GN=TOP2 PE=2 SV=1 PF00204//PF02969//PF00521 DNA gyrase B//TATA box binding protein associated factor (TAF)//DNA gyrase/topoisomerase IV, subunit A GO:0006265//GO:0006352 DNA topological change//DNA-templated transcription, initiation GO:0003677//GO:0003918//GO:0005524 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding GO:0005634 nucleus KOG0355 DNA topoisomerase type II Cluster-8309.29926 BF_2 379.23 2.56 6485 478255038 ENN75270.1 2558 1.0e-285 hypothetical protein YQE_08186, partial [Dendroctonus ponderosae]>gi|546673325|gb|ERL84953.1| hypothetical protein D910_02376 [Dendroctonus ponderosae] -- -- -- -- -- K14301 NUP107, NUP84 nuclear pore complex protein Nup107 http://www.genome.jp/dbget-bin/www_bget?ko:K14301 Q8BH74 1282 3.8e-139 Nuclear pore complex protein Nup107 OS=Mus musculus GN=Nup107 PE=2 SV=1 PF00514//PF04121//PF01465 Armadillo/beta-catenin-like repeat//Nuclear pore protein 84 / 107//GRIP domain GO:0006810//GO:0000042 transport//protein targeting to Golgi GO:0005515 protein binding GO:0005643 nuclear pore KOG1964 Nuclear pore complex, rNup107 component (sc Nup84) Cluster-8309.29927 BF_2 528.68 7.97 3063 642934707 XP_973046.2 3089 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 54 [Tribolium castaneum] -- -- -- -- -- K17600 VPS54 vacuolar protein sorting-associated protein 54 http://www.genome.jp/dbget-bin/www_bget?ko:K17600 Q9VLC0 1746 2.8e-193 Vacuolar protein sorting-associated protein 54 OS=Drosophila melanogaster GN=scat PE=1 SV=1 PF07928//PF04048 Vps54-like protein//Sec8 exocyst complex component specific domain GO:0006904//GO:0015031//GO:0042147 vesicle docking involved in exocytosis//protein transport//retrograde transport, endosome to Golgi -- -- GO:0000145 exocyst KOG2115 Vacuolar sorting protein VPS45 Cluster-8309.29928 BF_2 29.32 0.46 2971 642934707 XP_973046.2 3085 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 54 [Tribolium castaneum] -- -- -- -- -- K17600 VPS54 vacuolar protein sorting-associated protein 54 http://www.genome.jp/dbget-bin/www_bget?ko:K17600 Q9VLC0 1746 2.7e-193 Vacuolar protein sorting-associated protein 54 OS=Drosophila melanogaster GN=scat PE=1 SV=1 PF04048//PF07928 Sec8 exocyst complex component specific domain//Vps54-like protein GO:0006904//GO:0042147//GO:0015031 vesicle docking involved in exocytosis//retrograde transport, endosome to Golgi//protein transport -- -- GO:0000145 exocyst KOG2115 Vacuolar sorting protein VPS45 Cluster-8309.29929 BF_2 1297.96 20.16 2980 546678277 ERL88938.1 2764 6.1e-310 hypothetical protein D910_06316 [Dendroctonus ponderosae] 676485074 XM_009065298.1 66 2.7594e-23 Lottia gigantea hypothetical protein partial mRNA K11141 ENPEP glutamyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11141 Q07075 1739 1.8e-192 Glutamyl aminopeptidase OS=Homo sapiens GN=ENPEP PE=1 SV=3 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.29932 BF_2 703.33 15.85 2143 642916941 XP_008199564.1 845 1.4e-87 PREDICTED: mitochondrial import inner membrane translocase subunit Tim23 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q9WTQ8 390 3.4e-36 Mitochondrial import inner membrane translocase subunit Tim23 OS=Mus musculus GN=Timm23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3324 Mitochondrial import inner membrane translocase, subunit TIM23 Cluster-8309.29934 BF_2 20.67 1.22 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29935 BF_2 203.00 4.77 2069 478255559 ENN75776.1 567 2.4e-55 hypothetical protein YQE_07733, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VB74 523 1.3e-51 UPF0396 protein CG6066 OS=Drosophila melanogaster GN=CG6066 PE=1 SV=1 PF08290 Hepatitis core protein, putative zinc finger GO:0009405 pathogenesis GO:0005198 structural molecule activity -- -- KOG2812 Uncharacterized conserved protein Cluster-8309.29936 BF_2 139.00 1.00 6125 826464184 XP_012534808.1 1355 3.0e-146 PREDICTED: titin [Monomorium pharaonis] 642936078 XM_008200072.1 229 1.39708e-113 PREDICTED: Tribolium castaneum titin (LOC663321), transcript variant X2, mRNA -- -- -- -- Q9I7U4 184 7.6e-12 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.29937 BF_2 41.00 7.24 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29939 BF_2 82.37 2.52 1652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29940 BF_2 120.63 3.57 1702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29941 BF_2 1541.00 14.69 4675 189233655 XP_967467.2 2575 7.8e-288 PREDICTED: potassium voltage-gated channel protein Shal [Tribolium castaneum]>gi|270014520|gb|EFA10968.1| hypothetical protein TcasGA2_TC004130 [Tribolium castaneum] 642910598 XM_962374.3 735 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shal (LOC655814), mRNA K05321 KCNDN potassium voltage-gated channel Shal-related subfamily D, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05321 P17971 2411 3.4e-270 Potassium voltage-gated channel protein Shal OS=Drosophila melanogaster GN=Shal PE=1 SV=2 PF00520//PF02214 Ion transport protein//BTB/POZ domain GO:0055085//GO:0071805//GO:0051260//GO:0006813//GO:0006811//GO:0034765 transmembrane transport//potassium ion transmembrane transport//protein homooligomerization//potassium ion transport//ion transport//regulation of ion transmembrane transport GO:0005216//GO:0005249 ion channel activity//voltage-gated potassium channel activity GO:0016020//GO:0008076 membrane//voltage-gated potassium channel complex KOG4390 Voltage-gated A-type K+ channel KCND Cluster-8309.29942 BF_2 24.42 1.70 889 642934609 XP_008197736.1 681 6.2e-69 PREDICTED: corepressor interacting with RBPJ 1 [Tribolium castaneum]>gi|270013741|gb|EFA10189.1| hypothetical protein TcasGA2_TC012381 [Tribolium castaneum] 815894066 XM_012381482.1 149 5.81661e-70 PREDICTED: Bombus impatiens corepressor interacting with RBPJ 1 (LOC100748315), mRNA K06066 CIR CBF1 interacting corepressor http://www.genome.jp/dbget-bin/www_bget?ko:K06066 Q5ZI03 430 3.3e-41 Corepressor interacting with RBPJ 1 OS=Gallus gallus GN=CIR1 PE=2 SV=1 PF07496 CW-type Zinc Finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG3794 CBF1-interacting corepressor CIR and related proteins Cluster-8309.29946 BF_2 784.00 21.82 1790 642911762 XP_008200730.1 1745 5.3e-192 PREDICTED: major facilitator superfamily domain-containing protein 12-like isoform X1 [Tribolium castaneum]>gi|270014551|gb|EFA10999.1| hypothetical protein TcasGA2_TC004584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUT3 833 1.2e-87 Major facilitator superfamily domain-containing protein 12 OS=Homo sapiens GN=MFSD12 PE=1 SV=2 PF02674//PF00083//PF07690 Colicin V production protein//Sugar (and other) transporter//Major Facilitator Superfamily GO:0009403//GO:0055085 toxin biosynthetic process//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG4830 Predicted sugar transporter Cluster-8309.29949 BF_2 45.22 0.74 2839 642927274 XP_008195202.1 896 2.3e-93 PREDICTED: protein N-terminal glutamine amidohydrolase isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q968 652 1.9e-66 Protein N-terminal glutamine amidohydrolase OS=Anopheles gambiae GN=tun PE=3 SV=3 PF09764 N-terminal glutamine amidase GO:0006807 nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides -- -- KOG3261 Uncharacterized conserved protein Cluster-8309.29950 BF_2 10.55 0.37 1476 91083261 XP_966859.1 720 3.1e-73 PREDICTED: uncharacterized protein LOC663006 [Tribolium castaneum]>gi|270007764|gb|EFA04212.1| hypothetical protein TcasGA2_TC014461 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF00822//PF13903//PF05039 Clc-like//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction//Agouti protein GO:0009755 hormone-mediated signaling pathway -- -- GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.29951 BF_2 744.45 27.47 1421 332375068 AEE62675.1 1019 6.4e-108 unknown [Dendroctonus ponderosae]>gi|478252468|gb|ENN72890.1| hypothetical protein YQE_10460, partial [Dendroctonus ponderosae]>gi|546682586|gb|ERL92505.1| hypothetical protein D910_09818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF13903//PF05039 Clc-like//PMP-22/EMP/MP20/Claudin tight junction//Agouti protein GO:0009755 hormone-mediated signaling pathway -- -- GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.29952 BF_2 66.89 0.64 4662 642914151 XP_008201566.1 5110 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 Q6ZN16 2507 2.5e-281 Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens GN=MAP3K15 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG4279 Serine/threonine protein kinase Cluster-8309.29953 BF_2 8.00 1.44 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29956 BF_2 163.53 2.18 3420 478257812 ENN77955.1 340 8.3e-29 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0042254//GO:0001522 cellular protein modification process//ribosome biogenesis//pseudouridine synthesis GO:0030515//GO:0016151 snoRNA binding//nickel cation binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.29957 BF_2 536.61 5.60 4294 642912192 XP_008200846.1 742 2.5e-75 PREDICTED: transmembrane protein 127-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGP5 217 7.9e-16 Transmembrane protein 127 OS=Mus musculus GN=Tmem127 PE=2 SV=1 PF00515//PF04799 Tetratricopeptide repeat//fzo-like conserved region GO:0008053 mitochondrial fusion GO:0005515//GO:0003924 protein binding//GTPase activity GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane -- -- Cluster-8309.29961 BF_2 15.00 0.85 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29962 BF_2 21.05 0.81 1375 478257926 ENN78065.1 145 1.4e-06 hypothetical protein YQE_05459, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29965 BF_2 402.17 3.27 5428 612342210 AHW99830.1 7820 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1024 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 6693 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00487//PF01365 Fatty acid desaturase//RIH domain GO:0006629//GO:0070588//GO:0006816 lipid metabolic process//calcium ion transmembrane transport//calcium ion transport GO:0005262 calcium channel activity GO:0016020 membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.29966 BF_2 136.03 4.46 1563 728416984 AIY68330.1 1381 7.4e-150 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 621 4.1e-63 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.29967 BF_2 650.41 26.17 1327 403234001 AFR31785.1 1037 4.9e-110 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P08836 486 1.6e-47 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.29968 BF_2 13.10 0.45 1498 270007934 EFA04382.1 1466 9.9e-160 hypothetical protein TcasGA2_TC014680 [Tribolium castaneum] 689427973 LL903388.1 36 6.51877e-07 Schistocephalus solidus genome assembly S_solidus_NST_G2 ,scaffold SSLN_scaffold0003160 K07515 HADHA enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07515 Q29554 1075 8.9e-116 Trifunctional enzyme subunit alpha, mitochondrial OS=Sus scrofa GN=HADHA PE=1 SV=1 PF01048//PF02529//PF02737//PF03446//PF02826//PF00725 Phosphorylase superfamily//Cytochrome B6-F complex subunit 5//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO:0006550//GO:0006574//GO:0019521//GO:0006568//GO:0009116//GO:0055114//GO:0006554//GO:0006098//GO:0018874//GO:0006633//GO:0006631//GO:0006552 isoleucine catabolic process//valine catabolic process//D-gluconate metabolic process//tryptophan metabolic process//nucleoside metabolic process//oxidation-reduction process//lysine catabolic process//pentose-phosphate shunt//benzoate metabolic process//fatty acid biosynthetic process//fatty acid metabolic process//leucine catabolic process GO:0004616//GO:0003857//GO:0003824//GO:0051287//GO:0016491 phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//catalytic activity//NAD binding//oxidoreductase activity GO:0009512 cytochrome b6f complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.29969 BF_2 62.84 1.69 1846 546686194 ERL95574.1 592 2.7e-58 hypothetical protein D910_12835 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 242 4.3e-19 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF07776//PF06467//PF11648//PF00096//PF16622//PF01428//PF01844//PF13912//PF02892//PF00412//PF07975//PF13465 Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//C-terminal domain of RIG-I//Zinc finger, C2H2 type//zinc-finger C2H2-type//AN1-like Zinc finger//HNH endonuclease//C2H2-type zinc finger//BED zinc finger//LIM domain//TFIIH C1-like domain//Zinc-finger double domain GO:0006281 DNA repair GO:0003677//GO:0004519//GO:0003676//GO:0008270//GO:0046872//GO:0016817 DNA binding//endonuclease activity//nucleic acid binding//zinc ion binding//metal ion binding//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus -- -- Cluster-8309.29970 BF_2 248.07 0.88 12081 642920697 XP_008192527.1 625 2.6e-61 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202//PF04443//PF09726 Adipogenin//Acyl-protein synthetase, LuxE//Transmembrane protein GO:0008218//GO:0045444 bioluminescence//fat cell differentiation GO:0047474 long-chain fatty acid luciferin component ligase activity GO:0016021 integral component of membrane -- -- Cluster-8309.29971 BF_2 20.42 0.33 2885 189238011 XP_001813334.1 378 2.8e-33 PREDICTED: SH3 domain-binding glutamic acid-rich protein homolog [Tribolium castaneum]>gi|270008052|gb|EFA04500.1| hypothetical protein TcasGA2_TC014808 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NFP5 353 9.0e-32 SH3 domain-binding glutamic acid-rich protein homolog OS=Drosophila melanogaster GN=Sh3beta PE=1 SV=2 PF02798//PF00462 Glutathione S-transferase, N-terminal domain//Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG4023 Uncharacterized conserved protein Cluster-8309.29972 BF_2 7.00 1.46 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29973 BF_2 118.63 0.76 6814 642921666 XP_008192914.1 2161 1.2e-239 PREDICTED: polycomb protein Asx isoform X1 [Tribolium castaneum]>gi|270007351|gb|EFA03799.1| hypothetical protein TcasGA2_TC013912 [Tribolium castaneum] -- -- -- -- -- K11471 ASXL additional sex combs-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11471 Q9V727 566 4.3e-56 Polycomb protein Asx OS=Drosophila melanogaster GN=Asx PE=1 SV=1 PF13922//PF12515 PHD domain of transcriptional enhancer, Asx//Ca2+-ATPase N terminal autoinhibitory domain -- -- GO:0005516//GO:0003677 calmodulin binding//DNA binding -- -- -- -- Cluster-8309.29974 BF_2 43.55 0.57 3485 642915698 XP_008190764.1 3282 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X2 [Tribolium castaneum] 642915697 XM_008192542.1 550 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X2, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 5.3e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.29977 BF_2 596.00 40.75 899 282158103 NP_001164095.1 377 1.1e-33 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 P19109 273 5.3e-23 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.29978 BF_2 1.00 1.49 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29980 BF_2 268.63 3.20 3794 91083631 XP_970382.1 3795 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.50541e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2955 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF00005//PF02233//PF00107//PF07074//PF00205//PF02826//PF03188//PF01752 ABC transporter//NAD(P) transhydrogenase beta subunit//Zinc-binding dehydrogenase//Translocon-associated protein, gamma subunit (TRAP-gamma)//Thiamine pyrophosphate enzyme, central domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Collagenase GO:0006508//GO:0015992//GO:0006769//GO:0055114//GO:0006613//GO:0046497 proteolysis//proton transport//nicotinamide metabolic process//oxidation-reduction process//cotranslational protein targeting to membrane//nicotinate nucleotide metabolic process GO:0030976//GO:0000287//GO:0050661//GO:0051287//GO:0008270//GO:0016887//GO:0004252//GO:0005524//GO:0008750 thiamine pyrophosphate binding//magnesium ion binding//NADP binding//NAD binding//zinc ion binding//ATPase activity//serine-type endopeptidase activity//ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity GO:0005576//GO:0030176//GO:0005784//GO:0016021 extracellular region//integral component of endoplasmic reticulum membrane//Sec61 translocon complex//integral component of membrane -- -- Cluster-8309.29982 BF_2 920.75 75.11 800 91086587 XP_973540.1 618 1.1e-61 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 [Tribolium castaneum]>gi|270011002|gb|EFA07450.1| hypothetical protein TcasGA2_TC009080 [Tribolium castaneum] -- -- -- -- -- K03965 NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03965 Q9CQJ8 339 1.0e-30 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 OS=Mus musculus GN=Ndufb9 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3466 NADH:ubiquinone oxidoreductase, NDUFB9/B22 subunit Cluster-8309.29985 BF_2 132.28 2.00 3051 91079394 XP_971791.1 765 3.9e-78 PREDICTED: centrosomin isoform X2 [Tribolium castaneum] -- -- -- -- -- K16542 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16542 Q9BE52 259 7.6e-21 CDK5 regulatory subunit-associated protein 2 OS=Macaca fascicularis GN=CDK5RAP2 PE=2 SV=1 PF01221//PF07989//PF00769//PF02183 Dynein light chain type 1//Centrosomin N-terminal motif 1//Ezrin/radixin/moesin family//Homeobox associated leucine zipper GO:0006355//GO:0007017 regulation of transcription, DNA-templated//microtubule-based process GO:0008092//GO:0043565//GO:0003700 cytoskeletal protein binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0019898//GO:0005875//GO:0005815//GO:0005667//GO:0005737 extrinsic component of membrane//microtubule associated complex//microtubule organizing center//transcription factor complex//cytoplasm -- -- Cluster-8309.29986 BF_2 615.44 16.28 1869 817216800 XP_012284405.1 719 5.2e-73 PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus]>gi|817216802|ref|XP_012284407.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q9TU03 480 1.1e-46 Rho GDP-dissociation inhibitor 2 OS=Bos taurus GN=ARHGDIB PE=2 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.29987 BF_2 2.00 0.49 459 270013854 EFA10302.1 256 6.2e-20 hypothetical protein TcasGA2_TC012517 [Tribolium castaneum] 642935324 XM_008199747.1 86 3.04619e-35 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 163 1.5e-10 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF13639//PF00097//PF14634//PF17123 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger -- -- GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.29988 BF_2 8.10 0.42 1097 270006897 EFA03345.1 204 1.6e-13 hypothetical protein TcasGA2_TC013325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82979 130 2.5e-06 SAP domain-containing ribonucleoprotein OS=Homo sapiens GN=SARNP PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29989 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.29993 BF_2 497.14 7.60 3025 91082539 XP_973726.1 1448 2.4e-157 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 800 1.4e-83 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.29996 BF_2 1002.25 10.59 4245 642911211 XP_008199614.1 1434 1.4e-155 PREDICTED: LIX1-like protein [Tribolium castaneum] 158299715 XM_319761.3 144 1.72224e-66 Anopheles gambiae str. PEST AGAP009016-PA (AgaP_AGAP009016) mRNA, complete cds K16673 LIX1L LIX1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K16673 Q8IVB5 1016 1.8e-108 LIX1-like protein OS=Homo sapiens GN=LIX1L PE=2 SV=1 PF03368//PF05887 Dicer dimerisation domain//Procyclic acidic repetitive protein (PARP) GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters GO:0016020 membrane -- -- Cluster-8309.29998 BF_2 308.00 3.06 4498 546681097 ERL91253.1 2497 8.4e-279 hypothetical protein D910_08588 [Dendroctonus ponderosae] 820837626 XM_003690680.2 92 1.4726e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 2001 1.1e-222 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF00995//PF00992//PF08131//PF05739//PF16519//PF00804 Sec1 family//Troponin//Defensin-like peptide family//SNARE domain//Tetramerisation domain of TRPM//Syntaxin GO:0051262//GO:0016192//GO:0006904 protein tetramerization//vesicle-mediated transport//vesicle docking involved in exocytosis GO:0005515 protein binding GO:0016020//GO:0005576//GO:0005861 membrane//extracellular region//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.30000 BF_2 2.00 0.44 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30001 BF_2 40.57 2.45 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05281 Neuroendocrine protein 7B2 precursor (Secretogranin V) GO:0007218 neuropeptide signaling pathway -- -- GO:0030141 secretory granule -- -- Cluster-8309.30004 BF_2 13.00 1.42 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30005 BF_2 167.10 1.12 6513 646700010 KDR10365.1 926 1.8e-96 Angiopoietin-related protein 1 [Zootermopsis nevadensis] 578359011 KJ186851.1 44 1.02986e-10 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- Q9UKU9 544 1.4e-53 Angiopoietin-related protein 2 OS=Homo sapiens GN=ANGPTL2 PE=2 SV=1 PF04513//PF01607//PF04136//PF06009 Baculovirus polyhedron envelope protein, PEP, C terminus//Chitin binding Peritrophin-A domain//Sec34-like family//Laminin Domain II GO:0006886//GO:0006030//GO:0007155 intracellular protein transport//chitin metabolic process//cell adhesion GO:0005198//GO:0008061 structural molecule activity//chitin binding GO:0019031//GO:0019028//GO:0016020//GO:0005801//GO:0005576 viral envelope//viral capsid//membrane//cis-Golgi network//extracellular region -- -- Cluster-8309.30006 BF_2 56.00 2.80 1125 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30007 BF_2 137.34 4.84 1474 642915333 XP_008190576.1 324 2.6e-27 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K03904 FGB fibrinogen beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K03904 O95841 230 8.4e-18 Angiopoietin-related protein 1 OS=Homo sapiens GN=ANGPTL1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30008 BF_2 2040.64 15.11 5936 646700010 KDR10365.1 926 1.6e-96 Angiopoietin-related protein 1 [Zootermopsis nevadensis] 578359011 KJ186851.1 49 1.55947e-13 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- Q9UKU9 544 1.3e-53 Angiopoietin-related protein 2 OS=Homo sapiens GN=ANGPTL2 PE=2 SV=1 PF04136//PF01607//PF06009//PF04513 Sec34-like family//Chitin binding Peritrophin-A domain//Laminin Domain II//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007155//GO:0006886//GO:0006030 cell adhesion//intracellular protein transport//chitin metabolic process GO:0008061//GO:0005198 chitin binding//structural molecule activity GO:0005576//GO:0016020//GO:0005801//GO:0019031//GO:0019028 extracellular region//membrane//cis-Golgi network//viral envelope//viral capsid -- -- Cluster-8309.30010 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30012 BF_2 109.16 1.17 4186 642933107 XP_008197261.1 1670 6.1e-183 PREDICTED: prominin-like protein isoform X1 [Tribolium castaneum]>gi|270011437|gb|EFA07885.1| hypothetical protein TcasGA2_TC005459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 530 3.9e-52 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF05356//PF01442//PF05478//PF02417//PF13903//PF07464//PF07926//PF04513 Phage Coat protein B//Apolipoprotein A1/A4/E domain//Prominin//Chromate transporter//PMP-22/EMP/MP20/Claudin tight junction//Apolipophorin-III precursor (apoLp-III)//TPR/MLP1/MLP2-like protein//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006606//GO:0006869//GO:0015703//GO:0042157 protein import into nucleus//lipid transport//chromate transport//lipoprotein metabolic process GO:0015109//GO:0005198//GO:0008289 chromate transmembrane transporter activity//structural molecule activity//lipid binding GO:0005576//GO:0019031//GO:0016021//GO:0019028 extracellular region//viral envelope//integral component of membrane//viral capsid KOG4331 Polytopic membrane protein Prominin Cluster-8309.30013 BF_2 486.85 5.32 4118 642928027 XP_008200126.1 1921 4.7e-212 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.91441e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 993 7.9e-106 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF13202//PF04728//PF03836//PF00036//PF12763//PF10186//PF01920//PF07851//PF16326//PF04111//PF05531//PF13499//PF13833//PF13405 EF hand//Lipoprotein leucine-zipper//RasGAP C-terminus//EF hand//Cytoskeletal-regulatory complex EF hand//Vacuolar sorting 38 and autophagy-related subunit 14//Prefoldin subunit//TMPIT-like protein//ABC transporter C-terminal domain//Autophagy protein Apg6//Nucleopolyhedrovirus P10 protein//EF-hand domain pair//EF-hand domain pair//EF-hand domain GO:0006914//GO:0006457//GO:0010508//GO:0007264 autophagy//protein folding//positive regulation of autophagy//small GTPase mediated signal transduction GO:0005515//GO:0003677//GO:0005096//GO:0051082//GO:0005509 protein binding//DNA binding//GTPase activator activity//unfolded protein binding//calcium ion binding GO:0019028//GO:0016021//GO:0019867//GO:0016272 viral capsid//integral component of membrane//outer membrane//prefoldin complex KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.30014 BF_2 151.27 2.34 2987 332373138 AEE61710.1 919 5.3e-96 unknown [Dendroctonus ponderosae] 374719504 JN671475.1 88 1.62972e-35 Buccinum sp. JV-2012 catalase (cat) gene, partial cds K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 838 5.4e-88 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF03188//PF00199 Eukaryotic cytochrome b561//Catalase GO:0006568//GO:0055114//GO:0015947//GO:0006979//GO:0006804 tryptophan metabolic process//oxidation-reduction process//methane metabolic process//response to oxidative stress//obsolete peroxidase reaction GO:0020037//GO:0004096 heme binding//catalase activity GO:0016021 integral component of membrane KOG0047 Catalase Cluster-8309.30015 BF_2 64.00 0.82 3545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.30016 BF_2 50.78 0.89 2684 642929001 XP_008195650.1 2028 1.2e-224 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 845 7.5e-89 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF08686//PF05986 PLAC (protease and lacunin) domain//ADAM-TS Spacer 1 -- -- GO:0008233//GO:0004222 peptidase activity//metalloendopeptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.30019 BF_2 362.85 4.93 3365 91093116 XP_967543.1 2214 4.1e-246 PREDICTED: serine/threonine-protein kinase GL21140 [Tribolium castaneum]>gi|270001184|gb|EEZ97631.1| hypothetical protein TcasGA2_TC016079 [Tribolium castaneum] -- -- -- -- -- K08805 DCLK1_2 doublecortin-like kinase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08805 B4IT27 1235 5.6e-134 Serine/threonine-protein kinase GE16371 OS=Drosophila yakuba GN=GE16371 PE=3 SV=2 PF06293//PF00069//PF07714//PF03607//PF00292 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Doublecortin//'Paired box' domain GO:0006355//GO:0035556//GO:0006468//GO:0009069//GO:0016310 regulation of transcription, DNA-templated//intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0004674//GO:0004672//GO:0005524//GO:0003677 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding//DNA binding GO:0005622//GO:0016020 intracellular//membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.30024 BF_2 1924.84 30.58 2920 91076148 XP_970492.1 943 8.5e-99 PREDICTED: yorkie homolog isoform X1 [Tribolium castaneum]>gi|270014715|gb|EFA11163.1| hypothetical protein TcasGA2_TC004769 [Tribolium castaneum] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q45VV3 309 1.2e-26 Transcriptional coactivator yorkie OS=Drosophila melanogaster GN=yki PE=1 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.30025 BF_2 750.29 16.25 2219 478250226 ENN70727.1 932 1.2e-97 hypothetical protein YQE_12557, partial [Dendroctonus ponderosae]>gi|478270147|gb|ENN83468.1| hypothetical protein YQE_00176, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RBL0 456 7.9e-44 Protein YIPF1 OS=Pongo abelii GN=YIPF1 PE=2 SV=1 PF04893//PF15454//PF13291 Yip1 domain//Late endosomal/lysosomal adaptor and MAPK and MTOR activator//ACT domain GO:0001919//GO:0042632//GO:0043410//GO:0007040//GO:0032439//GO:0008152//GO:0071230//GO:0032008 regulation of receptor recycling//cholesterol homeostasis//positive regulation of MAPK cascade//lysosome organization//endosome localization//metabolic process//cellular response to amino acid stimulus//positive regulation of TOR signaling GO:0016597 amino acid binding GO:0045121//GO:0016020//GO:0031902//GO:0071986 membrane raft//membrane//late endosome membrane//Ragulator complex KOG3114 Uncharacterized conserved protein Cluster-8309.30026 BF_2 128.71 2.89 2149 478250226 ENN70727.1 932 1.2e-97 hypothetical protein YQE_12557, partial [Dendroctonus ponderosae]>gi|478270147|gb|ENN83468.1| hypothetical protein YQE_00176, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RBL0 456 7.6e-44 Protein YIPF1 OS=Pongo abelii GN=YIPF1 PE=2 SV=1 PF04893//PF15454//PF13291 Yip1 domain//Late endosomal/lysosomal adaptor and MAPK and MTOR activator//ACT domain GO:0042632//GO:0001919//GO:0043410//GO:0007040//GO:0071230//GO:0008152//GO:0032008//GO:0032439 cholesterol homeostasis//regulation of receptor recycling//positive regulation of MAPK cascade//lysosome organization//cellular response to amino acid stimulus//metabolic process//positive regulation of TOR signaling//endosome localization GO:0016597 amino acid binding GO:0045121//GO:0016020//GO:0031902//GO:0071986 membrane raft//membrane//late endosome membrane//Ragulator complex KOG3114 Uncharacterized conserved protein Cluster-8309.30030 BF_2 238.60 2.34 4551 642928153 XP_008200179.1 3557 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 1A isoform X2 [Tribolium castaneum] -- -- -- -- -- K11655 BAZ1A, ACF1 bromodomain adjacent to zinc finger domain protein 1A http://www.genome.jp/dbget-bin/www_bget?ko:K11655 Q9NRL2 535 1.1e-52 Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens GN=BAZ1A PE=1 SV=2 PF00628//PF00439 PHD-finger//Bromodomain -- -- GO:0005515 protein binding -- -- KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.30031 BF_2 960.50 22.21 2096 91083309 XP_974698.1 2406 1.4e-268 PREDICTED: xaa-Pro aminopeptidase 1 [Tribolium castaneum]>gi|270007740|gb|EFA04188.1| hypothetical protein TcasGA2_TC014437 [Tribolium castaneum] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q9NQW7 1788 2.6e-198 Xaa-Pro aminopeptidase 1 OS=Homo sapiens GN=XPNPEP1 PE=1 SV=3 PF01321 Creatinase/Prolidase N-terminal domain GO:0009987 cellular process GO:0016787//GO:0046872 hydrolase activity//metal ion binding -- -- KOG2413 Xaa-Pro aminopeptidase Cluster-8309.30032 BF_2 306.50 7.31 2041 91083309 XP_974698.1 2406 1.4e-268 PREDICTED: xaa-Pro aminopeptidase 1 [Tribolium castaneum]>gi|270007740|gb|EFA04188.1| hypothetical protein TcasGA2_TC014437 [Tribolium castaneum] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q9NQW7 1788 2.5e-198 Xaa-Pro aminopeptidase 1 OS=Homo sapiens GN=XPNPEP1 PE=1 SV=3 PF01321 Creatinase/Prolidase N-terminal domain GO:0009987 cellular process GO:0046872//GO:0016787 metal ion binding//hydrolase activity -- -- KOG2413 Xaa-Pro aminopeptidase Cluster-8309.30033 BF_2 111.77 0.56 8606 642923695 XP_008193847.1 5437 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1636 4.5e-180 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF15723 Motility quorum-sensing regulator, toxin of MqsA GO:0009372//GO:0017148//GO:0042710 quorum sensing//negative regulation of translation//biofilm formation -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.30035 BF_2 1302.46 6.78 8329 642923693 XP_008193845.1 4235 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 2136 4.6e-238 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF15723//PF03361 Motility quorum-sensing regulator, toxin of MqsA//Herpes virus intermediate/early protein 2/3 GO:0017148//GO:0042710//GO:0009372//GO:0006355 negative regulation of translation//biofilm formation//quorum sensing//regulation of transcription, DNA-templated -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.30036 BF_2 2085.09 10.57 8536 642923695 XP_008193847.1 6957 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 2117 7.6e-236 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF05927//PF03361//PF15723 Penaeidin//Herpes virus intermediate/early protein 2/3//Motility quorum-sensing regulator, toxin of MqsA GO:0009372//GO:0042710//GO:0017148//GO:0006355 quorum sensing//biofilm formation//negative regulation of translation//regulation of transcription, DNA-templated GO:0008061 chitin binding GO:0005737 cytoplasm KOG1893 Uncharacterized conserved protein Cluster-8309.30039 BF_2 645.18 13.66 2263 91077058 XP_968505.1 2308 3.5e-257 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 2.57167e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 Q0V7M0 1916 4.1e-213 Importin subunit alpha-7 OS=Bos taurus GN=KPNA6 PE=2 SV=1 PF02985//PF01749//PF16006//PF10508//PF11698//PF00514//PF01602 HEAT repeat//Importin beta binding domain//Nucleolar and spindle-associated protein//Proteasome non-ATPase 26S subunit//V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region GO:0043248//GO:0006606//GO:0015031//GO:0016192//GO:0006886//GO:0000281//GO:0000226//GO:0040001//GO:0015991 proteasome assembly//protein import into nucleus//protein transport//vesicle-mediated transport//intracellular protein transport//mitotic cytokinesis//microtubule cytoskeleton organization//establishment of mitotic spindle localization//ATP hydrolysis coupled proton transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0005737//GO:0030117//GO:0005819//GO:0005634//GO:0005874//GO:0000221 cytoplasm//membrane coat//spindle//nucleus//microtubule//vacuolar proton-transporting V-type ATPase, V1 domain KOG0166 Karyopherin (importin) alpha Cluster-8309.30040 BF_2 30.76 0.86 1792 91090512 XP_969653.1 670 2.4e-67 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BPE4 262 2.0e-21 Transmembrane protein 177 OS=Mus musculus GN=Tmem177 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30041 BF_2 33.15 1.10 1547 91090512 XP_969653.1 798 2.9e-82 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q53S58 308 8.0e-27 Transmembrane protein 177 OS=Homo sapiens GN=TMEM177 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30043 BF_2 539.00 15.30 1761 332376999 AEE63639.1 902 2.9e-94 unknown [Dendroctonus ponderosae]>gi|478256765|gb|ENN76946.1| hypothetical protein YQE_06591, partial [Dendroctonus ponderosae]>gi|546679224|gb|ERL89718.1| hypothetical protein D910_07079 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2KIB0 682 3.9e-70 Fumarylacetoacetate hydrolase domain-containing protein 2 OS=Bos taurus GN=FAHD2 PE=2 SV=1 PF01557 Fumarylacetoacetate (FAA) hydrolase family GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1535 Predicted fumarylacetoacetate hydralase Cluster-8309.30044 BF_2 8.01 1.05 606 642928380 XP_008192720.1 226 2.4e-16 PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|642928382|ref|XP_008192721.1| PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|270010784|gb|EFA07232.1| hypothetical protein TcasGA2_TC010589 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30045 BF_2 118.90 1.79 3064 91076900 XP_975025.1 1726 1.4e-189 PREDICTED: Y+L amino acid transporter 2 [Tribolium castaneum] 817087970 XM_012411364.1 77 2.17854e-29 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q9UHI5 1043 9.3e-112 Large neutral amino acids transporter small subunit 2 OS=Homo sapiens GN=SLC7A8 PE=1 SV=1 PF01424//PF00324//PF13520//PF01990 R3H domain//Amino acid permease//Amino acid permease//ATP synthase (F/14-kDa) subunit GO:0003333//GO:0006865//GO:0055085//GO:0034220//GO:0006810 amino acid transmembrane transport//amino acid transport//transmembrane transport//ion transmembrane transport//transport GO:0003676//GO:0015171 nucleic acid binding//amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30046 BF_2 769.00 25.66 1541 91084671 XP_966504.1 1152 2.6e-123 PREDICTED: lambda-crystallin [Tribolium castaneum]>gi|270008625|gb|EFA05073.1| hypothetical protein TcasGA2_TC015170 [Tribolium castaneum] -- -- -- -- -- K13247 CRYL1 L-gulonate 3-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K13247 Q811X6 803 3.2e-84 Lambda-crystallin homolog OS=Rattus norvegicus GN=Cryl1 PE=2 SV=3 PF00725//PF07992//PF02737//PF00056//PF02826//PF03446//PF03721//PF02558//PF01210 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Ketopantoate reductase PanE/ApbA//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GO:0046168//GO:0018874//GO:0006098//GO:0006633//GO:0006552//GO:0006631//GO:0006550//GO:0006574//GO:0015940//GO:0006554//GO:0055114//GO:0019521//GO:0006568 glycerol-3-phosphate catabolic process//benzoate metabolic process//pentose-phosphate shunt//fatty acid biosynthetic process//leucine catabolic process//fatty acid metabolic process//isoleucine catabolic process//valine catabolic process//pantothenate biosynthetic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process GO:0016491//GO:0070403//GO:0051287//GO:0008677//GO:0016616//GO:0003857//GO:0004616 oxidoreductase activity//NAD+ binding//NAD binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG2304 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.30050 BF_2 587.05 4.27 6045 642936704 XP_008198546.1 2616 1.8e-292 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 158 7.7e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF00008//PF02793//PF13895 EGF-like domain//Hormone receptor domain//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.30051 BF_2 18.00 0.36 2352 270004837 EFA01285.1 1617 4.8e-177 hypothetical protein TcasGA2_TC002917 [Tribolium castaneum] 751780154 XM_011200889.1 36 1.0324e-06 PREDICTED: Bactrocera dorsalis probable G-protein coupled receptor 139 (LOC105223237), mRNA -- -- -- -- Q8SWR3 1176 2.7e-127 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF00001//PF15491 7 transmembrane receptor (rhodopsin family)//CST, telomere maintenance, complex subunit CTC1 GO:0007186//GO:0000723 G-protein coupled receptor signaling pathway//telomere maintenance GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.30053 BF_2 10.16 0.32 1602 817194717 XP_012272871.1 927 3.4e-97 PREDICTED: guanine nucleotide-binding protein subunit alpha homolog [Orussus abietinus] -- -- -- -- -- K04346 GNA12 guanine nucleotide-binding protein subunit alpha-12 http://www.genome.jp/dbget-bin/www_bget?ko:K04346 P25157 795 2.8e-83 Guanine nucleotide-binding protein subunit alpha homolog OS=Drosophila melanogaster GN=cta PE=2 SV=1 PF00503//PF00025 G-protein alpha subunit//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0003924//GO:0005525//GO:0004871//GO:0019001//GO:0031683 GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.30054 BF_2 178.84 4.61 1909 642935937 XP_008198237.1 1534 1.6e-167 PREDICTED: guanine nucleotide-binding protein subunit alpha homolog [Tribolium castaneum] -- -- -- -- -- K04346 GNA12 guanine nucleotide-binding protein subunit alpha-12 http://www.genome.jp/dbget-bin/www_bget?ko:K04346 P25157 1248 9.8e-136 Guanine nucleotide-binding protein subunit alpha homolog OS=Drosophila melanogaster GN=cta PE=2 SV=1 PF00503//PF00025//PF01580//PF04670//PF08477//PF01926 G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family//Gtr1/RagA G protein conserved region//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003677//GO:0005524//GO:0003924//GO:0019001//GO:0004871//GO:0000166//GO:0005525 G-protein beta/gamma-subunit complex binding//DNA binding//ATP binding//GTPase activity//guanyl nucleotide binding//signal transducer activity//nucleotide binding//GTP binding -- -- -- -- Cluster-8309.30056 BF_2 166.00 26.72 547 478254770 ENN75006.1 233 3.4e-17 hypothetical protein YQE_08323, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30057 BF_2 513.18 24.46 1165 -- -- -- -- -- 642917523 XM_008193017.1 66 1.05948e-23 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03964 Chorion family 2 GO:0007275 multicellular organismal development -- -- GO:0042600 chorion -- -- Cluster-8309.30058 BF_2 9.41 0.38 1319 817193593 XP_012272264.1 146 1.0e-06 PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193595|ref|XP_012272265.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193597|ref|XP_012272266.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.30059 BF_2 1040.62 6.74 6744 642928254 XP_008195509.1 3216 0.0e+00 PREDICTED: bifunctional glutamate/proline--tRNA ligase [Tribolium castaneum] 170063636 XM_001867153.1 194 4.40008e-94 Culex quinquefasciatus bifunctional aminoacyl-tRNA synthetase, mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 2719 9.3e-306 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF00992//PF00749//PF00587//PF02146//PF00458//PF09180//PF03012//PF03950 Troponin//tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetase class II core domain (G, H, P, S and T)//Sir2 family//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Phosphoprotein//tRNA synthetases class I (E and Q), anti-codon binding domain GO:0019083//GO:0006525//GO:0006433//GO:0006418//GO:0043039//GO:0006560//GO:0006144 viral transcription//arginine metabolic process//prolyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//tRNA aminoacylation//proline metabolic process//purine nucleobase metabolic process GO:0000166//GO:0016876//GO:0004812//GO:0005524//GO:0004827//GO:0003968//GO:0070403 nucleotide binding//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity//ATP binding//proline-tRNA ligase activity//RNA-directed RNA polymerase activity//NAD+ binding GO:0005737//GO:0031379//GO:0005861 cytoplasm//RNA-directed RNA polymerase complex//troponin complex KOG4163 Prolyl-tRNA synthetase Cluster-8309.30060 BF_2 15.21 0.39 1908 546686114 ERL95506.1 352 1.9e-30 hypothetical protein D910_12768 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5EB30 165 3.8e-10 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30062 BF_2 174.61 4.64 1860 642910469 XP_008200226.1 1071 7.8e-114 PREDICTED: uncharacterized protein LOC659133 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 242 4.3e-19 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.30064 BF_2 1.00 20.55 216 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30065 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30069 BF_2 72.63 3.71 1107 478262394 ENN81065.1 271 2.7e-21 hypothetical protein YQE_02434, partial [Dendroctonus ponderosae]>gi|546673614|gb|ERL85178.1| hypothetical protein D910_02600 [Dendroctonus ponderosae] -- -- -- -- -- K16365 SGTA small glutamine-rich tetratricopeptide repeat-containing protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16365 O43765 144 5.9e-08 Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens GN=SGTA PE=1 SV=1 PF13414//PF00515 TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0553 TPR repeat-containing protein Cluster-8309.30070 BF_2 209.24 7.71 1423 91095123 XP_970890.1 564 3.7e-55 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 430 5.2e-41 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF02229 short chain dehydrogenase//Transcriptional Coactivator p15 (PC4) GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated GO:0003677//GO:0003713//GO:0016491 DNA binding//transcription coactivator activity//oxidoreductase activity GO:0005667 transcription factor complex -- -- Cluster-8309.30072 BF_2 200.11 2.88 3191 642917789 XP_008191287.1 901 6.9e-94 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X1 [Tribolium castaneum] 403179775 XM_003338024.2 42 6.49236e-10 Puccinia graminis f. sp. tritici CRL 75-36-700-3 glucosamine-fructose-6-phosphate aminotransferase (PGTG_19602), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 P47856 629 9.9e-64 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 OS=Mus musculus GN=Gfpt1 PE=1 SV=3 PF11593 Mediator complex subunit 3 fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.30073 BF_2 146.25 1.04 6154 642917793 XP_008191289.1 2136 8.3e-237 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X3 [Tribolium castaneum] 768412757 XM_011570168.1 425 0 PREDICTED: Plutella xylostella glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like (LOC105398114), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 1723 2.6e-190 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF11593//PF13580//PF01380 Mediator complex subunit 3 fungal//SIS domain//SIS domain GO:0005975//GO:0006357 carbohydrate metabolic process//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0030246 RNA polymerase II transcription cofactor activity//carbohydrate binding GO:0016592 mediator complex KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.30074 BF_2 460.23 6.53 3234 642928365 XP_008192713.1 1314 9.0e-142 PREDICTED: uncharacterized protein LOC103312832 isoform X1 [Tribolium castaneum]>gi|270010785|gb|EFA07233.1| hypothetical protein TcasGA2_TC010590 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VRJ8 423 7.7e-40 Protein Asterix OS=Drosophila melanogaster GN=CG10674 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3462 Predicted membrane protein Cluster-8309.30076 BF_2 424.57 4.07 4652 642928280 XP_008195517.1 1862 3.7e-205 PREDICTED: uncharacterized protein LOC658443 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12737 SDCCAG10 peptidyl-prolyl cis-trans isomerase SDCCAG10 http://www.genome.jp/dbget-bin/www_bget?ko:K12737 Q6UX04 644 2.6e-65 Peptidyl-prolyl cis-trans isomerase CWC27 homolog OS=Homo sapiens GN=CWC27 PE=1 SV=1 PF00160//PF02601 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Exonuclease VII, large subunit GO:0006457//GO:0006308//GO:0000413 protein folding//DNA catabolic process//protein peptidyl-prolyl isomerization GO:0003755//GO:0008855 peptidyl-prolyl cis-trans isomerase activity//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG0885 Peptidyl-prolyl cis-trans isomerase Cluster-8309.30077 BF_2 177.38 3.07 2704 642928762 XP_008199773.1 2901 0.0e+00 PREDICTED: nephrin [Tribolium castaneum] 642928761 XM_008201551.1 611 0 PREDICTED: Tribolium castaneum nephrin (LOC663236), mRNA -- -- -- -- Q8WZ42 241 8.2e-19 Titin OS=Homo sapiens GN=TTN PE=1 SV=4 PF13895//PF04850//PF00041 Immunoglobulin domain//Baculovirus E66 occlusion-derived virus envelope protein//Fibronectin type III domain -- -- GO:0005515 protein binding GO:0019031 viral envelope -- -- Cluster-8309.30078 BF_2 457.18 8.47 2546 642927700 XP_008196611.1 1675 9.8e-184 PREDICTED: LOW QUALITY PROTEIN: oxidative stress-induced growth inhibitor 2-like [Tribolium castaneum] 642927699 XM_008198389.1 99 1.06478e-41 PREDICTED: Tribolium castaneum oxidative stress-induced growth inhibitor 2-like (LOC655536), mRNA -- -- -- -- Q9UJX0 433 4.2e-41 Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=1 SV=3 PF07992//PF01494//PF00070 Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491//GO:0071949 oxidoreductase activity//FAD binding -- -- -- -- Cluster-8309.30079 BF_2 55.75 0.71 3570 91083575 XP_968060.1 685 8.6e-69 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q28GD9 228 3.5e-17 Ribonuclease H2 subunit B OS=Xenopus tropicalis GN=rnaseh2b PE=2 SV=1 PF01786 Alternative oxidase GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009916 alternative oxidase activity GO:0005634 nucleus -- -- Cluster-8309.30080 BF_2 37.06 0.34 4834 332374250 AEE62266.1 1780 1.2e-195 unknown [Dendroctonus ponderosae]>gi|478251803|gb|ENN72249.1| hypothetical protein YQE_11112, partial [Dendroctonus ponderosae]>gi|546684740|gb|ERL94350.1| hypothetical protein D910_11631 [Dendroctonus ponderosae] -- -- -- -- -- K01102 PDP pyruvate dehydrogenase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01102 Q3UV70 957 1.4e-101 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Mus musculus GN=Pdp1 PE=2 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0700 Protein phosphatase 2C/pyruvate dehydrogenase (lipoamide) phosphatase Cluster-8309.30083 BF_2 10.14 0.33 1571 589094703 AHK59785.1 521 3.9e-50 major facilitator superfamily protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.30085 BF_2 14.35 0.41 1765 91076836 XP_974707.1 821 7.2e-85 PREDICTED: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [Tribolium castaneum]>gi|270001821|gb|EEZ98268.1| hypothetical protein TcasGA2_TC000711 [Tribolium castaneum] 462377192 APGK01023399.1 60 3.51108e-20 Dendroctonus ponderosae Seq01023409, whole genome shotgun sequence K00167 BCKDHB, bkdA2 2-oxoisovalerate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00167 P21839 705 8.4e-73 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Bos taurus GN=BCKDHB PE=1 SV=2 PF02780//PF00199 Transketolase, C-terminal domain//Catalase GO:0015947//GO:0008152//GO:0006804//GO:0006979//GO:0006568//GO:0055114 methane metabolic process//metabolic process//obsolete peroxidase reaction//response to oxidative stress//tryptophan metabolic process//oxidation-reduction process GO:0004096//GO:0003824//GO:0020037 catalase activity//catalytic activity//heme binding -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.30087 BF_2 209.00 3.68 2661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30089 BF_2 66.03 0.54 5405 827548948 XP_012546635.1 2755 1.2e-308 PREDICTED: von Willebrand factor A domain-containing protein 8 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q8CC88 2294 1.4e-256 von Willebrand factor A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=2 SV=2 PF02562//PF00421//PF00004//PF00158//PF01926//PF07728//PF08477//PF01695//PF00910//PF00493//PF00006//PF01637//PF03193//PF07726//PF00005//PF07724//PF01443 PhoH-like protein//Photosystem II protein//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//IstB-like ATP binding protein//RNA helicase//MCM2/3/5 family//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//AAA domain (Cdc48 subfamily)//Viral (Superfamily 1) RNA helicase GO:0009767//GO:0007264//GO:0006355//GO:0006260//GO:0019684 photosynthetic electron transport chain//small GTPase mediated signal transduction//regulation of transcription, DNA-templated//DNA replication//photosynthesis, light reaction GO:0003723//GO:0003677//GO:0005525//GO:0003724//GO:0005524//GO:0016168//GO:0008134//GO:0003924//GO:0016887 RNA binding//DNA binding//GTP binding//RNA helicase activity//ATP binding//chlorophyll binding//transcription factor binding//GTPase activity//ATPase activity GO:0005667//GO:0016020//GO:0009521 transcription factor complex//membrane//photosystem KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.30091 BF_2 543.58 2.40 9748 642928397 XP_008192729.1 3555 0.0e+00 PREDICTED: homeobox protein prospero isoform X3 [Tribolium castaneum] 642928396 XM_008194507.1 1300 0 PREDICTED: Tribolium castaneum homeobox protein prospero (LOC660328), transcript variant X4, mRNA -- -- -- -- P29617 965 3.3e-102 Homeobox protein prospero OS=Drosophila melanogaster GN=pros PE=1 SV=3 PF15556//PF13855//PF00560//PF05044 ZW10 interactor//Leucine rich repeat//Leucine Rich Repeat//Homeo-prospero domain GO:0007093 mitotic cell cycle checkpoint GO:0003677//GO:0005515 DNA binding//protein binding GO:0000776 kinetochore KOG3779 Homeobox transcription factor prospero Cluster-8309.30095 BF_2 85.00 5.88 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30097 BF_2 56.00 4.17 849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30098 BF_2 65.95 1.29 2431 478257402 ENN77558.1 757 2.6e-77 hypothetical protein YQE_05854, partial [Dendroctonus ponderosae] -- -- -- -- -- K17757 CARKD ATP-dependent NAD(P)H-hydrate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K17757 E3XDZ8 539 2.0e-53 ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Anopheles darlingi GN=AND_21715 PE=3 SV=1 PF01256 Carbohydrate kinase -- -- GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity -- -- KOG3974 Predicted sugar kinase Cluster-8309.30099 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30103 BF_2 790.34 3.98 8585 642931063 XP_008196196.1 1688 1.0e-184 PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|642931065|ref|XP_008196197.1| PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|270011892|gb|EFA08340.1| hypothetical protein TcasGA2_TC005983 [Tribolium castaneum] 195484142 XM_002090535.1 90 3.6482e-36 Drosophila yakuba RpS26 (Dyak\RpS26), partial mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 Q9GT45 503 1.1e-48 40S ribosomal protein S26 OS=Anopheles gambiae GN=RpS26 PE=3 SV=2 PF15473//PF01283 PEST, proteolytic signal-containing nuclear protein family//Ribosomal protein S26e GO:0042254//GO:0016567//GO:0006412 ribosome biogenesis//protein ubiquitination//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-8309.30104 BF_2 1667.77 5.73 12458 270006541 EFA02989.1 7387 0.0e+00 hypothetical protein TcasGA2_TC010408 [Tribolium castaneum] 642922985 XM_008202260.1 1251 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase TRIP12 (LOC658915), transcript variant X4, mRNA K10590 TRIP12 E3 ubiquitin-protein ligase TRIP12 http://www.genome.jp/dbget-bin/www_bget?ko:K10590 G5E870 4375 0.0e+00 E3 ubiquitin-protein ligase TRIP12 OS=Mus musculus GN=Trip12 PE=1 SV=1 PF13174//PF00632//PF00514//PF04049//PF12470//PF13181//PF13414//PF13176//PF13374//PF00515//PF13371 Tetratricopeptide repeat//HECT-domain (ubiquitin-transferase)//Armadillo/beta-catenin-like repeat//Anaphase promoting complex subunit 8 / Cdc23//Suppressor of Fused Gli/Ci N terminal binding domain//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0016567//GO:0030071 protein ubiquitination//regulation of mitotic metaphase/anaphase transition GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0170 E3 ubiquitin protein ligase Cluster-8309.30106 BF_2 28.58 1.68 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30107 BF_2 20.14 106.70 251 642932342 XP_008197073.1 182 1.3e-11 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30108 BF_2 49.30 1.20 2005 270001371 EEZ97818.1 1190 1.3e-127 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914994 XM_008192253.1 391 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X5, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 O60506 769 3.6e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens GN=SYNCRIP PE=1 SV=2 PF16622//PF00076//PF16367 zinc-finger C2H2-type//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.30109 BF_2 151.00 7.92 1085 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30112 BF_2 576.58 14.44 1957 546686493 ERL95715.1 920 2.7e-96 hypothetical protein D910_00153 [Dendroctonus ponderosae]>gi|546687391|gb|ERL96116.1| hypothetical protein D910_01091 [Dendroctonus ponderosae] 665801637 XM_008550618.1 178 9.89258e-86 PREDICTED: Microplitis demolitor corepressor interacting with RBPJ 1 (LOC103572157), mRNA K06066 CIR CBF1 interacting corepressor http://www.genome.jp/dbget-bin/www_bget?ko:K06066 Q86X95 503 2.5e-49 Corepressor interacting with RBPJ 1 OS=Homo sapiens GN=CIR1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3794 CBF1-interacting corepressor CIR and related proteins Cluster-8309.30113 BF_2 274.88 6.88 1959 642933417 XP_008197409.1 1572 6.6e-172 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1066 1.3e-114 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.30114 BF_2 47.92 1.34 1781 642933417 XP_008197409.1 1625 4.3e-178 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1073 1.8e-115 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30115 BF_2 1246.36 33.36 1850 642933417 XP_008197409.1 1607 5.5e-176 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1081 2.2e-116 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30116 BF_2 15.84 0.43 1811 642933417 XP_008197409.1 1406 1.1e-152 PREDICTED: cytochrome P450 9e2-like [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 942 2.8e-100 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.30117 BF_2 454.48 2.36 8355 91082665 XP_971149.1 1312 4.0e-141 PREDICTED: lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial [Tribolium castaneum]>gi|270015048|gb|EFA11496.1| hypothetical protein TcasGA2_TC014209 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q920M9 1094 3.1e-117 E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2 PF03145//PF02817//PF05191//PF00097//PF00198//PF02224 Seven in absentia protein family//e3 binding domain//Adenylate kinase, active site lid//Zinc finger, C3HC4 type (RING finger)//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Cytidylate kinase GO:0006511//GO:0006206//GO:0008152//GO:0007275//GO:0006144//GO:0046034//GO:0006139 ubiquitin-dependent protein catabolic process//pyrimidine nucleobase metabolic process//metabolic process//multicellular organismal development//purine nucleobase metabolic process//ATP metabolic process//nucleobase-containing compound metabolic process GO:0004127//GO:0004017//GO:0046872//GO:0005524//GO:0016746 cytidylate kinase activity//adenylate kinase activity//metal ion binding//ATP binding//transferase activity, transferring acyl groups GO:0005634 nucleus KOG0558 Dihydrolipoamide transacylase (alpha-keto acid dehydrogenase E2 subunit) Cluster-8309.30120 BF_2 54.34 1.45 1858 189237581 XP_974946.2 1126 3.3e-120 PREDICTED: glypican-6 [Tribolium castaneum] -- -- -- -- -- K08110 GPC4 glypican 4 (K-glypican) http://www.genome.jp/dbget-bin/www_bget?ko:K08110 Q5RE54 627 9.8e-64 Glypican-6 OS=Pongo abelii GN=GPC6 PE=2 SV=1 PF01153 Glypican -- -- GO:0043395 heparan sulfate proteoglycan binding GO:0005578//GO:0016020 proteinaceous extracellular matrix//membrane KOG3821 Heparin sulfate cell surface proteoglycan Cluster-8309.30121 BF_2 526.96 3.47 6641 91076250 XP_966964.1 1806 1.6e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 1.32064e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 3.0e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF15009//PF07648//PF08527//PF00050//PF13833//PF00036//PF10591 Transmembrane protein 173//Kazal-type serine protease inhibitor domain//Protein-arginine deiminase (PAD) middle domain//Kazal-type serine protease inhibitor domain//EF-hand domain pair//EF hand//Secreted protein acidic and rich in cysteine Ca binding region GO:0007165//GO:0018101//GO:0002218//GO:0006807//GO:0032481 signal transduction//protein citrullination//activation of innate immune response//nitrogen compound metabolic process//positive regulation of type I interferon production GO:0005515//GO:0005509//GO:0004668 protein binding//calcium ion binding//protein-arginine deiminase activity GO:0005578//GO:0005737 proteinaceous extracellular matrix//cytoplasm KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.30122 BF_2 29.33 1.04 1467 646713645 KDR17927.1 356 5.0e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 6.0e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30123 BF_2 14.82 2.13 578 282165788 NP_001164133.1 263 1.2e-20 scavenger receptor protein [Tribolium castaneum]>gi|270009221|gb|EFA05669.1| hypothetical protein TcasGA2_TC014951 [Tribolium castaneum] -- -- -- -- -- K13885 SCARB1 scavenger receptor class B, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13885 Q61009 162 2.5e-10 Scavenger receptor class B member 1 OS=Mus musculus GN=Scarb1 PE=1 SV=1 PF01130//PF04790 CD36 family//Sarcoglycan complex subunit protein GO:0007155 cell adhesion -- -- GO:0016020//GO:0016021//GO:0016012 membrane//integral component of membrane//sarcoglycan complex -- -- Cluster-8309.30125 BF_2 147.71 3.45 2079 478255293 ENN75519.1 1572 7.0e-172 hypothetical protein YQE_07863, partial [Dendroctonus ponderosae]>gi|546683153|gb|ERL93004.1| hypothetical protein D910_10306 [Dendroctonus ponderosae] 820848257 XM_012486488.1 41 1.51327e-09 PREDICTED: Apis florea PAB-dependent poly(A)-specific ribonuclease subunit PAN3 (LOC100865909), transcript variant X4, mRNA K12572 PAN3 PAB-dependent poly(A)-specific ribonuclease subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12572 Q95RR8 1019 3.8e-109 PAB-dependent poly(A)-specific ribonuclease subunit PAN3 OS=Drosophila melanogaster GN=CG11486 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG3741 Poly(A) ribonuclease subunit Cluster-8309.30126 BF_2 57.00 8.77 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30127 BF_2 79.00 4.19 1076 91080531 XP_966681.1 1492 6.9e-163 PREDICTED: protein mab-21 [Tribolium castaneum]>gi|270005805|gb|EFA02253.1| hypothetical protein TcasGA2_TC007916 [Tribolium castaneum] 805787052 XM_003703263.2 308 2.90374e-158 PREDICTED: Megachile rotundata protein mab-21 (LOC100883216), mRNA -- -- -- -- Q5TW90 1384 9.4e-152 Protein mab-21 OS=Anopheles gambiae GN=mab-21 PE=3 SV=3 -- -- GO:0045165 cell fate commitment -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.30130 BF_2 311.00 18.38 995 478254655 ENN74896.1 171 9.6e-10 hypothetical protein YQE_08474, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02133//PF05454//PF00335 Permease for cytosine/purines, uracil, thiamine, allantoin//Dystroglycan (Dystrophin-associated glycoprotein 1)//Tetraspanin family GO:0007016//GO:0055085//GO:0006810 cytoskeletal anchoring at plasma membrane//transmembrane transport//transport GO:0005215 transporter activity GO:0016021//GO:0016010//GO:0016020 integral component of membrane//dystrophin-associated glycoprotein complex//membrane -- -- Cluster-8309.30131 BF_2 568.84 7.83 3327 642910948 XP_008193477.1 3019 0.0e+00 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 2124 4.5e-237 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0070008//GO:0004252//GO:0008236 serine-type exopeptidase activity//serine-type endopeptidase activity//serine-type peptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.30132 BF_2 47.34 0.52 4113 642910948 XP_008193477.1 1972 5.8e-218 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 1403 2.3e-153 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0070008 serine-type peptidase activity//serine-type endopeptidase activity//serine-type exopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.30134 BF_2 182.00 3.27 2619 -- -- -- -- -- 642929258 XM_008197536.1 81 1.11135e-31 PREDICTED: Tribolium castaneum translin (LOC103313671), mRNA -- -- -- -- -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.30136 BF_2 2.00 0.52 448 642915333 XP_008190576.1 137 3.8e-06 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30138 BF_2 157.00 12.73 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30140 BF_2 42.43 0.41 4589 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.63133e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 2.0e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186//PF00278 Vacuolar sorting 38 and autophagy-related subunit 14//Pyridoxal-dependent decarboxylase, C-terminal sheet domain GO:0010508 positive regulation of autophagy GO:0003824 catalytic activity -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.30141 BF_2 98.50 2.63 1854 270012020 EFA08468.1 340 4.5e-29 hypothetical protein TcasGA2_TC006118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32P12 204 1.1e-14 Uncharacterized protein C17orf53 homolog OS=Mus musculus PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30145 BF_2 40.74 1.06 1894 642923143 XP_008193628.1 241 1.4e-17 PREDICTED: nuclear receptor coactivator 3 isoform X7 [Tribolium castaneum] 642923146 XM_008195408.1 242 2.53181e-121 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30146 BF_2 209.25 2.22 4232 642938764 XP_008199878.1 658 1.4e-65 PREDICTED: uncharacterized protein LOC656472 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30147 BF_2 628.88 14.41 2113 642921500 XP_001811085.2 1096 1.1e-116 PREDICTED: venom acid phosphatase Acph-1-like [Tribolium castaneum]>gi|270006248|gb|EFA02696.1| hypothetical protein TcasGA2_TC008418 [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q5BLY5 645 9.1e-66 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.30148 BF_2 44.61 0.52 3904 642930728 XP_008200003.1 1104 2.4e-117 PREDICTED: sorting nexin-8 [Tribolium castaneum] -- -- -- -- -- K17922 SNX8, MVP1 sorting nexin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K17922 Q2KHV6 543 1.1e-53 Sorting nexin-8 OS=Bos taurus GN=SNX8 PE=2 SV=1 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- -- -- Cluster-8309.30150 BF_2 2064.28 30.66 3104 91082031 XP_970514.1 1373 1.2e-148 PREDICTED: elongation of very long chain fatty acids protein 6 [Tribolium castaneum]>gi|270007304|gb|EFA03752.1| hypothetical protein TcasGA2_TC013861 [Tribolium castaneum] 642921969 XM_965421.3 282 2.42658e-143 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein 6 (LOC659089), mRNA K10203 ELOVL6 elongation of very long chain fatty acids protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10203 Q5ZJR8 682 6.9e-70 Elongation of very long chain fatty acids protein 6 OS=Gallus gallus GN=ELOVL6 PE=2 SV=1 PF08273//PF01151 Zinc-binding domain of primase-helicase//GNS1/SUR4 family GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0008270//GO:0003896//GO:0004386 zinc ion binding//DNA primase activity//helicase activity GO:0005730//GO:0005657//GO:0016021 nucleolus//replication fork//integral component of membrane KOG3072 Long chain fatty acid elongase Cluster-8309.30151 BF_2 37.72 0.93 1990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30154 BF_2 35.86 0.58 2853 557332086 XP_006038864.1 379 2.1e-33 PREDICTED: zinc finger protein 850-like [Alligator sinensis] -- -- -- -- -- K09229 ZKSCAN KRAB and SCAN domains-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09229 Q9EQB9 365 3.6e-33 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF07975//PF13465//PF02701//PF16622//PF02892//PF13912//PF01155//PF02772//PF00096 TFIIH C1-like domain//Zinc-finger double domain//Dof domain, zinc finger//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//S-adenosylmethionine synthetase, central domain//Zinc finger, C2H2 type GO:0006464//GO:0006281//GO:0006355//GO:0006556//GO:0006555 cellular protein modification process//DNA repair//regulation of transcription, DNA-templated//S-adenosylmethionine biosynthetic process//methionine metabolic process GO:0003677//GO:0004478//GO:0016151//GO:0008270//GO:0046872 DNA binding//methionine adenosyltransferase activity//nickel cation binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.30155 BF_2 8.90 0.35 1350 309318773 BAJ23047.1 281 2.3e-22 peptidoglycan-recognition protein-SC2 [Tenebrio molitor] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V4X2 182 2.8e-12 Peptidoglycan-recognition protein SC2 OS=Drosophila melanogaster GN=PGRP-SC2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30156 BF_2 172.23 7.31 1273 91086137 XP_968906.1 154 1.1e-07 PREDICTED: sister chromatid cohesion protein PDS5 homolog B isoform X1 [Tribolium castaneum]>gi|270010223|gb|EFA06671.1| hypothetical protein TcasGA2_TC009599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30158 BF_2 3.00 0.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30159 BF_2 9.00 0.86 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3016 BF_2 12.00 0.70 1009 755756742 XP_011283311.1 1453 2.1e-158 PREDICTED: 60S ribosomal protein L5 [Felis catus] 71772259 NM_000969.3 1009 0 Homo sapiens ribosomal protein L5 (RPL5), mRNA K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 P46777 1447 4.4e-159 60S ribosomal protein L5 OS=Homo sapiens GN=RPL5 PE=1 SV=3 PF00861 Ribosomal L18p/L5e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0875 60S ribosomal protein L5 Cluster-8309.30161 BF_2 826.00 18.66 2139 568253343 ETN62507.1 1616 5.7e-177 GTP-binding protein alpha subunit, gna [Anopheles darlingi] 662190831 XM_008469977.1 185 1.39099e-89 PREDICTED: Diaphorina citri guanine nucleotide-binding protein G(s) subunit alpha (LOC103505624), mRNA K04632 GNAS guanine nucleotide-binding protein G(s) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04632 Q7PD79 1612 6.8e-178 Guanine nucleotide-binding protein G(s) subunit alpha OS=Anopheles gambiae GN=G-s-alpha-60A PE=2 SV=1 PF04670//PF00025//PF00503//PF08477 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//G-protein alpha subunit//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003924//GO:0005525//GO:0004871//GO:0019001 G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0099 G protein subunit Galphas, small G protein superfamily Cluster-8309.30162 BF_2 88.86 3.08 1495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30164 BF_2 103.24 1.04 4452 221115973 XP_002165005.1 1003 1.4e-105 PREDICTED: uncharacterized protein LOC100209733 [Hydra vulgaris] -- -- -- -- -- -- -- -- -- Q52V16 273 2.6e-22 Zinc finger Y-chromosomal protein OS=Gorilla gorilla gorilla GN=ZFY PE=3 SV=1 PF02150//PF06397//PF00096//PF13465//PF03184 RNA polymerases M/15 Kd subunit//Desulfoferrodoxin, N-terminal domain//Zinc finger, C2H2 type//Zinc-finger double domain//DDE superfamily endonuclease GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0003676//GO:0005506//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//nucleic acid binding//iron ion binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.30165 BF_2 118.49 1.85 2962 642913109 XP_008201396.1 1484 1.6e-161 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 5.37674e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 926 3.3e-98 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.30166 BF_2 110.96 3.04 1812 91093218 XP_967029.1 379 1.3e-33 PREDICTED: GTP cyclohydrolase 1 isoform X1 [Tribolium castaneum]>gi|270016588|gb|EFA13034.1| hypothetical protein TcasGA2_TC010564 [Tribolium castaneum] 241989293 AK336271.1 118 2.06566e-52 Triticum aestivum cDNA, clone: SET3_K11, cultivar: Chinese Spring -- -- -- -- P48596 277 3.7e-23 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2698 GTP cyclohydrolase I Cluster-8309.30168 BF_2 12.15 0.68 1039 270010086 EFA06534.1 506 1.4e-48 hypothetical protein TcasGA2_TC009438 [Tribolium castaneum] 312094587 XM_003148025.1 56 3.41417e-18 Loa loa 40S ribosomal protein S11 (LOAG_12512) mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P62282 485 1.6e-47 40S ribosomal protein S11 OS=Rattus norvegicus GN=Rps11 PE=1 SV=3 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.30169 BF_2 599.87 4.71 5615 91081723 XP_971735.1 1723 5.9e-189 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005067|gb|EFA01515.1| hypothetical protein TcasGA2_TC007074 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 1039 5.0e-111 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF08031//PF01061//PF13304//PF00005//PF03193 Berberine and berberine like//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0055114 oxidation-reduction process GO:0017111//GO:0005525//GO:0000166//GO:0016887//GO:0050660//GO:0003924//GO:0016491//GO:0005524 nucleoside-triphosphatase activity//GTP binding//nucleotide binding//ATPase activity//flavin adenine dinucleotide binding//GTPase activity//oxidoreductase activity//ATP binding GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.30170 BF_2 1187.86 7.06 7327 332375100 AEE62691.1 2046 2.7e-226 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 1064 8.2e-114 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01695//PF00005//PF03193//PF01061//PF13304//PF01926//PF08031 IstB-like ATP binding protein//ABC transporter//Protein of unknown function, DUF258//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Berberine and berberine like GO:0055114 oxidation-reduction process GO:0005524//GO:0003924//GO:0016491//GO:0016887//GO:0050660//GO:0005525 ATP binding//GTPase activity//oxidoreductase activity//ATPase activity//flavin adenine dinucleotide binding//GTP binding GO:0016020 membrane -- -- Cluster-8309.30173 BF_2 67.21 0.37 7806 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.3e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF01926//PF08477//PF03193//PF03810//PF00071//PF02421 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Importin-beta N-terminal domain//Ras family//Ferrous iron transport protein B GO:0015684//GO:0015031//GO:0007264//GO:0006886 ferrous iron transport//protein transport//small GTPase mediated signal transduction//intracellular protein transport GO:0008565//GO:0005525//GO:0015093//GO:0003924//GO:0008536 protein transporter activity//GTP binding//ferrous iron transmembrane transporter activity//GTPase activity//Ran GTPase binding GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.30174 BF_2 688.06 18.41 1851 642910658 XP_008200046.1 2157 9.1e-240 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7TMY8 1827 6.9e-203 E3 ubiquitin-protein ligase HUWE1 OS=Mus musculus GN=Huwe1 PE=1 SV=5 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30175 BF_2 460.81 1.70 11655 642910658 XP_008200046.1 10432 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3569 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30176 BF_2 61.12 1.37 2159 642910658 XP_008200046.1 1974 1.8e-218 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 1692 3.7e-187 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30178 BF_2 97.69 0.35 11947 642910658 XP_008200046.1 8538 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.30179 BF_2 123.00 1.36 4071 91090296 XP_971651.1 1831 1.3e-201 PREDICTED: nitric oxide-associated protein 1 [Tribolium castaneum]>gi|270013800|gb|EFA10248.1| hypothetical protein TcasGA2_TC012448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NC60 908 5.6e-96 Nitric oxide-associated protein 1 OS=Homo sapiens GN=NOA1 PE=1 SV=2 PF08477//PF03193//PF01926//PF07817//PF00071//PF02421 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//GLE1-like protein//Ras family//Ferrous iron transport protein B GO:0007264//GO:0015684//GO:0016973 small GTPase mediated signal transduction//ferrous iron transport//poly(A)+ mRNA export from nucleus GO:0005525//GO:0003924//GO:0015093 GTP binding//GTPase activity//ferrous iron transmembrane transporter activity GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.30181 BF_2 322.49 2.87 4982 189241194 XP_969137.2 697 4.9e-70 PREDICTED: transmembrane protein 47 [Tribolium castaneum] 642935837 XM_964044.3 167 3.31543e-79 PREDICTED: Tribolium castaneum transmembrane protein 47 (LOC657593), mRNA -- -- -- -- -- -- -- -- PF00517//PF00822//PF00957//PF13903 Retroviral envelope protein//PMP-22/EMP/MP20/Claudin family//Synaptobrevin//PMP-22/EMP/MP20/Claudin tight junction GO:0016192 vesicle-mediated transport GO:0005198 structural molecule activity GO:0016021//GO:0019031 integral component of membrane//viral envelope KOG4671 Brain cell membrane protein 1 (BCMP1) Cluster-8309.30182 BF_2 343.74 3.13 4877 270013966 EFA10414.1 684 1.5e-68 hypothetical protein TcasGA2_TC012654 [Tribolium castaneum] 642935837 XM_964044.3 164 1.50977e-77 PREDICTED: Tribolium castaneum transmembrane protein 47 (LOC657593), mRNA -- -- -- -- -- -- -- -- PF00517//PF06687//PF13903//PF06072//PF00957//PF00822 Retroviral envelope protein//SUR7/PalI family//PMP-22/EMP/MP20/Claudin tight junction//Alphaherpesvirus tegument protein US9//Synaptobrevin//PMP-22/EMP/MP20/Claudin family GO:0016192 vesicle-mediated transport GO:0005198 structural molecule activity GO:0005886//GO:0016021//GO:0019033//GO:0019031 plasma membrane//integral component of membrane//viral tegument//viral envelope KOG4671 Brain cell membrane protein 1 (BCMP1) Cluster-8309.30185 BF_2 357.40 2.46 6363 642934045 XP_008197618.1 1078 4.1e-114 PREDICTED: kelch-like protein 38 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 237 5.6e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF01344//PF00023//PF01370//PF00651//PF07992//PF07646//PF13606 Kelch motif//Ankyrin repeat//NAD dependent epimerase/dehydratase family//BTB/POZ domain//Pyridine nucleotide-disulphide oxidoreductase//Kelch motif//Ankyrin repeat GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0003824//GO:0050662 oxidoreductase activity//protein binding//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.30186 BF_2 386.21 5.94 3007 642917749 XP_008191355.1 3019 0.0e+00 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q179T2 933 5.2e-99 Exonuclease mut-7 homolog OS=Aedes aegypti GN=AAEL005527 PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- KOG4373 Predicted 3'-5' exonuclease Cluster-8309.30189 BF_2 11.63 0.74 948 100811805 BAE94685.1 1081 2.8e-115 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 402 6.1e-38 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00740//PF00326//PF07859 Parvovirus coat protein VP2//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0005198//GO:0016787 serine-type peptidase activity//structural molecule activity//hydrolase activity GO:0019028 viral capsid -- -- Cluster-8309.30190 BF_2 169.53 2.58 3040 642913836 XP_001815393.2 1519 1.4e-165 PREDICTED: engulfment and cell motility protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92556 411 1.8e-38 Engulfment and cell motility protein 1 OS=Homo sapiens GN=ELMO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30192 BF_2 178.90 6.15 1505 546681897 ERL91906.1 877 2.0e-91 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 468 2.2e-45 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.30196 BF_2 167.09 1.33 5562 642924920 XP_008194097.1 1312 2.6e-141 PREDICTED: microtubule-associated protein futsch isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMF0 209 8.7e-15 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 PF02205//PF02196 WH2 motif//Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057//GO:0003779 receptor signaling protein activity//actin binding -- -- -- -- Cluster-8309.30199 BF_2 16.61 0.44 1882 546672758 ERL84523.1 2050 2.4e-227 hypothetical protein D910_01953 [Dendroctonus ponderosae] 642928406 XM_966741.2 233 2.53333e-116 PREDICTED: Tribolium castaneum cysteine sulfinic acid decarboxylase-like (LOC660516), mRNA K01580 E4.1.1.15, gadB, gadA, GAD glutamate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01580 Q0VCA1 1242 4.8e-135 Glutamate decarboxylase 1 OS=Bos taurus GN=GAD1 PE=2 SV=1 PF05889//PF01212//PF00282//PF00155//PF01276 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain//Aminotransferase class I and II//Orn/Lys/Arg decarboxylase, major domain GO:0019752//GO:0009058//GO:0006520 carboxylic acid metabolic process//biosynthetic process//cellular amino acid metabolic process GO:0016740//GO:0016831//GO:0003824//GO:0030170//GO:0016829 transferase activity//carboxy-lyase activity//catalytic activity//pyridoxal phosphate binding//lyase activity -- -- KOG0629 Glutamate decarboxylase and related proteins Cluster-8309.30201 BF_2 20.31 0.34 2800 91084625 XP_974579.1 1191 1.4e-127 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 638 7.8e-65 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.30204 BF_2 969.29 5.31 7924 546681997 ERL91993.1 4107 0.0e+00 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2242 2.2e-250 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF09026//PF05456//PF06701 Centromere protein B dimerisation domain//Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Mib_herc2 GO:0016567//GO:0045947//GO:0006355 protein ubiquitination//negative regulation of translational initiation//regulation of transcription, DNA-templated GO:0004842//GO:0003677//GO:0008190//GO:0003682//GO:0046872 ubiquitin-protein transferase activity//DNA binding//eukaryotic initiation factor 4E binding//chromatin binding//metal ion binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region KOG4276 Predicted hormone receptor interactor Cluster-8309.30205 BF_2 72.69 1.23 2757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10538 Immunoreceptor tyrosine-based activation motif GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.30208 BF_2 216.81 0.92 10111 642933099 XP_973043.3 2910 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.2e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF14572//PF08587 Phosphoribosyl transferase domain//Phosphoribosyl synthetase-associated domain//Ubiquitin associated domain (UBA) GO:0009116//GO:0009069//GO:0006144//GO:0009165//GO:0016310//GO:0006098 nucleoside metabolic process//serine family amino acid metabolic process//purine nucleobase metabolic process//nucleotide biosynthetic process//phosphorylation//pentose-phosphate shunt GO:0004749//GO:0000287//GO:0004674 ribose phosphate diphosphokinase activity//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30211 BF_2 704.33 2.69 11237 642933099 XP_973043.3 3459 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.3e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF08587//PF14572//PF00076 Phosphoribosyl transferase domain//Ubiquitin associated domain (UBA)//Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0009116//GO:0006144//GO:0009069//GO:0009165//GO:0016310//GO:0006098 nucleoside metabolic process//purine nucleobase metabolic process//serine family amino acid metabolic process//nucleotide biosynthetic process//phosphorylation//pentose-phosphate shunt GO:0004749//GO:0004674//GO:0000287//GO:0003676 ribose phosphate diphosphokinase activity//protein serine/threonine kinase activity//magnesium ion binding//nucleic acid binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30213 BF_2 740.53 2.72 11659 642933099 XP_973043.3 2372 6.8e-264 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA -- -- -- -- Q5ZL26 1288 1.4e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF14572//PF00076//PF08587//PF00156 Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ubiquitin associated domain (UBA)//Phosphoribosyl transferase domain GO:0016310//GO:0009165//GO:0009069//GO:0006144//GO:0006098//GO:0009116 phosphorylation//nucleotide biosynthetic process//serine family amino acid metabolic process//purine nucleobase metabolic process//pentose-phosphate shunt//nucleoside metabolic process GO:0000287//GO:0004674//GO:0004749//GO:0003676 magnesium ion binding//protein serine/threonine kinase activity//ribose phosphate diphosphokinase activity//nucleic acid binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.30215 BF_2 2294.76 61.27 1854 91077396 XP_975299.1 2446 2.8e-273 PREDICTED: T-complex protein 1 subunit theta [Tribolium castaneum]>gi|270002115|gb|EEZ98562.1| hypothetical protein TcasGA2_TC001073 [Tribolium castaneum] -- -- -- -- -- K09500 CCT8 T-complex protein 1 subunit theta http://www.genome.jp/dbget-bin/www_bget?ko:K09500 Q6EE31 1813 2.9e-201 T-complex protein 1 subunit theta OS=Gallus gallus GN=CCT8 PE=1 SV=3 PF00118//PF06389 TCP-1/cpn60 chaperonin family//Filovirus membrane-associated protein VP24 GO:0006457//GO:0016032 protein folding//viral process GO:0005198//GO:0005524//GO:0051082 structural molecule activity//ATP binding//unfolded protein binding GO:0005737//GO:0016020 cytoplasm//membrane KOG0362 Chaperonin complex component, TCP-1 theta subunit (CCT8) Cluster-8309.30216 BF_2 108.02 3.64 1527 91091700 XP_972740.1 779 4.6e-80 PREDICTED: mannosyl-oligosaccharide glucosidase [Tribolium castaneum]>gi|270001063|gb|EEZ97510.1| hypothetical protein TcasGA2_TC011354 [Tribolium castaneum] -- -- -- -- -- K01228 GCS1 mannosyl-oligosaccharide glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01228 Q13724 349 1.4e-31 Mannosyl-oligosaccharide glucosidase OS=Homo sapiens GN=MOGS PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2161 Glucosidase I Cluster-8309.30218 BF_2 3854.17 134.04 1490 189235746 XP_967247.2 727 4.8e-74 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 395 6.3e-37 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137 Adenosine-deaminase (editase) domain GO:0006396//GO:0006144//GO:0006807 RNA processing//purine nucleobase metabolic process//nitrogen compound metabolic process GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.30219 BF_2 1218.58 47.56 1359 91082701 XP_971906.1 1077 1.1e-114 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] 332375702 BT128031.1 171 5.30546e-82 Dendroctonus ponderosae clone DPO089_M20 unknown mRNA -- -- -- -- O15126 498 6.5e-49 Secretory carrier-associated membrane protein 1 OS=Homo sapiens GN=SCAMP1 PE=1 SV=2 PF04144//PF00049 SCAMP family//Insulin/IGF/Relaxin family GO:0007165//GO:0015031 signal transduction//protein transport GO:0005179 hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3088 Secretory carrier membrane protein Cluster-8309.30220 BF_2 14.48 0.50 1488 91082701 XP_971906.1 687 2.1e-69 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] 332375702 BT128031.1 143 2.13902e-66 Dendroctonus ponderosae clone DPO089_M20 unknown mRNA -- -- -- -- O15126 337 3.3e-30 Secretory carrier-associated membrane protein 1 OS=Homo sapiens GN=SCAMP1 PE=1 SV=2 PF00049//PF04144 Insulin/IGF/Relaxin family//SCAMP family GO:0015031//GO:0007165 protein transport//signal transduction GO:0005179 hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG3088 Secretory carrier membrane protein Cluster-8309.30221 BF_2 18.25 1.15 953 91082701 XP_971906.1 216 5.6e-15 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28F21 162 4.2e-10 Secretory carrier-associated membrane protein 5 OS=Xenopus tropicalis GN=scamp5 PE=2 SV=1 PF04144 SCAMP family GO:0015031 protein transport -- -- GO:0016021 integral component of membrane KOG3088 Secretory carrier membrane protein Cluster-8309.30225 BF_2 237.92 1.23 8363 642930342 XP_008196356.1 4733 0.0e+00 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 986 0 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- P35580 408 1.1e-37 Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 PF08702//PF02183//PF10473//PF07989//PF09730//PF10174//PF05550//PF05531//PF06156//PF04111//PF04048 Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Microtubule-associated protein Bicaudal-D//RIM-binding protein of the cytomatrix active zone//Pestivirus Npro endopeptidase C53//Nucleopolyhedrovirus P10 protein//Protein of unknown function (DUF972)//Autophagy protein Apg6//Sec8 exocyst complex component specific domain GO:0007165//GO:0051258//GO:0006914//GO:0006810//GO:0019082//GO:0006355//GO:0006260//GO:0015031//GO:0016032//GO:0006904//GO:0030168 signal transduction//protein polymerization//autophagy//transport//viral protein processing//regulation of transcription, DNA-templated//DNA replication//protein transport//viral process//vesicle docking involved in exocytosis//platelet activation GO:0008134//GO:0045502//GO:0043565//GO:0005102//GO:0003700//GO:0030674//GO:0042803 transcription factor binding//dynein binding//sequence-specific DNA binding//receptor binding//transcription factor activity, sequence-specific DNA binding//protein binding, bridging//protein homodimerization activity GO:0005815//GO:0019028//GO:0005794//GO:0048786//GO:0005577//GO:0030286//GO:0005667//GO:0000145 microtubule organizing center//viral capsid//Golgi apparatus//presynaptic active zone//fibrinogen complex//dynein complex//transcription factor complex//exocyst -- -- Cluster-8309.30226 BF_2 9.00 0.64 877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30227 BF_2 62.04 0.51 5351 642918584 XP_966986.2 1643 1.1e-179 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVD5 252 8.6e-20 Leucine-rich repeat-containing G-protein coupled receptor 6 OS=Mus musculus GN=Lgr6 PE=2 SV=1 PF07926//PF00560//PF16331//PF04977//PF13855//PF06005//PF10392 TPR/MLP1/MLP2-like protein//Leucine Rich Repeat//TolA binding protein trimerisation//Septum formation initiator//Leucine rich repeat//Protein of unknown function (DUF904)//Golgi transport complex subunit 5 GO:0006606//GO:0007049//GO:0000917//GO:0043093//GO:0006891//GO:0070206 protein import into nucleus//cell cycle//barrier septum assembly//FtsZ-dependent cytokinesis//intra-Golgi vesicle-mediated transport//protein trimerization GO:0005515 protein binding GO:0017119//GO:0005737 Golgi transport complex//cytoplasm KOG0619 FOG: Leucine rich repeat Cluster-8309.30230 BF_2 14.13 0.35 1977 642936794 XP_008199618.1 252 7.7e-19 PREDICTED: protein kish-A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWH8 231 8.7e-18 Protein kish OS=Drosophila melanogaster GN=ksh PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30231 BF_2 50.00 3.09 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30232 BF_2 172.11 3.43 2385 189233695 XP_001812208.1 494 8.1e-47 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 369 1.0e-33 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF16367//PF00076//PF08777//PF00010 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif//Helix-loop-helix DNA-binding domain -- -- GO:0003723//GO:0003676//GO:0046983 RNA binding//nucleic acid binding//protein dimerization activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.30233 BF_2 581.00 17.69 1661 91076616 XP_969309.1 1481 2.0e-161 PREDICTED: uncharacterized protein LOC657780 [Tribolium castaneum]>gi|270002630|gb|EEZ99077.1| hypothetical protein TcasGA2_TC004956 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30234 BF_2 523.87 3.54 6486 189240413 XP_969795.2 2244 2.6e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.34924e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.4e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00498//PF00250 FHA domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0005515 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005667 transcription factor complex -- -- Cluster-8309.30235 BF_2 380.36 2.54 6553 189240413 XP_969795.2 2244 2.6e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.36326e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.4e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0005515//GO:0003700 sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.30237 BF_2 146.26 1.59 4133 270013705 EFA10153.1 426 1.1e-38 hypothetical protein TcasGA2_TC012341 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205//PF01213//PF02861 WH2 motif//Adenylate cyclase associated (CAP) N terminal//Clp amino terminal domain, pathogenicity island component GO:0007010//GO:0019538 cytoskeleton organization//protein metabolic process GO:0003779 actin binding -- -- -- -- Cluster-8309.30241 BF_2 111.80 0.69 7112 642931401 XP_008196564.1 7544 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 [Tribolium castaneum] 170051315 XM_001861674.1 59 5.16114e-19 Culex quinquefasciatus BIG3, mRNA K17572 ARFGEF3, KEPI brefeldin A-inhibited guanine nucleotide-exchange protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17572 Q3UGY8 1258 2.5e-136 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Mus musculus GN=Arfgef3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.30246 BF_2 9.00 0.67 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30247 BF_2 110.50 4.85 1241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17097 Spindle pole body component -- -- -- -- GO:0000775 chromosome, centromeric region -- -- Cluster-8309.30248 BF_2 375.06 4.19 4032 189240877 XP_971050.2 855 1.9e-88 PREDICTED: leucine-rich repeat flightless-interacting protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4V7E8 407 6.9e-38 Leucine-rich repeat flightless-interacting protein 2 OS=Rattus norvegicus GN=Lrrfip2 PE=2 SV=1 PF05557//PF00769 Mitotic checkpoint protein//Ezrin/radixin/moesin family GO:0007094 mitotic spindle assembly checkpoint GO:0008092 cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG2010 Double stranded RNA binding protein Cluster-8309.3025 BF_2 48.92 1.20 1996 -- -- -- -- -- 642915699 XM_008192543.1 136 2.24753e-62 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF05210 Sprouty protein (Spry) GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development -- -- GO:0016020 membrane -- -- Cluster-8309.30253 BF_2 7.12 0.32 1220 741829513 AJA91072.1 893 2.2e-93 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 614 2.1e-62 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067//PF04608 Cytochrome P450//Phosphatidylglycerophosphatase A GO:0055114//GO:0006629//GO:0046486 oxidation-reduction process//lipid metabolic process//glycerolipid metabolic process GO:0020037//GO:0008962//GO:0005506//GO:0016705 heme binding//phosphatidylglycerophosphatase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30256 BF_2 222.03 6.42 1733 642922662 XP_008193267.1 1328 1.2e-143 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] 198470107 XM_002133335.1 46 2.08876e-12 Drosophila pseudoobscura pseudoobscura GA22859 (Dpse\GA22859), partial mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 934 2.3e-99 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0046872//GO:0005506//GO:0016491//GO:0016705 heme binding//metal ion binding//iron ion binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30257 BF_2 871.60 19.41 2166 817063934 XP_012253687.1 2161 3.7e-240 PREDICTED: histone deacetylase Rpd3 [Athalia rosae] 642917923 XM_961540.2 542 0 PREDICTED: Tribolium castaneum histone deacetylase Rpd3 (LOC655044), mRNA K06067 HDAC1_2 histone deacetylase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06067 Q94517 2126 1.7e-237 Histone deacetylase Rpd3 OS=Drosophila melanogaster GN=Rpd3 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.30259 BF_2 212.91 4.62 2216 861650871 KMQ97471.1 2131 1.1e-236 histone deacetylase rpd3 [Lasius niger] 642917923 XM_961540.2 542 0 PREDICTED: Tribolium castaneum histone deacetylase Rpd3 (LOC655044), mRNA K06067 HDAC1_2 histone deacetylase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06067 Q94517 2124 3.0e-237 Histone deacetylase Rpd3 OS=Drosophila melanogaster GN=Rpd3 PE=1 SV=2 PF13691 tRNase Z endonuclease GO:0008033 tRNA processing -- -- -- -- KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.30260 BF_2 9.00 1.20 601 241781846 XP_002400305.1 325 8.0e-28 fatty acid-binding protein FABP, putative [Ixodes scapularis]>gi|215510729|gb|EEC20182.1| fatty acid-binding protein FABP, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- Q17284 169 4.0e-11 Fatty acid-binding protein OS=Blomia tropicalis PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.30262 BF_2 17.09 0.54 1618 642923453 XP_008193751.1 1009 1.1e-106 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QM06 393 1.2e-36 Sterol regulatory element-binding protein cleavage-activating protein OS=Bos taurus GN=SCAP PE=2 SV=1 PF00400//PF07569//PF01437 WD domain, G-beta repeat//TUP1-like enhancer of split//Plexin repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020//GO:0005634 membrane//nucleus KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.30264 BF_2 37.00 2.69 862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30265 BF_2 20.12 0.41 2361 91079020 XP_974879.1 654 2.2e-65 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q7ZT42 387 8.4e-36 Staphylococcal nuclease domain-containing protein 1 OS=Danio rerio GN=snd1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.30266 BF_2 1351.00 24.11 2631 91083669 XP_968061.1 2736 9.4e-307 PREDICTED: transmembrane 9 superfamily member 4 [Tribolium castaneum]>gi|642924284|ref|XP_008194231.1| PREDICTED: transmembrane 9 superfamily member 4 [Tribolium castaneum] -- -- -- -- -- K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q5RDY2 1922 9.5e-214 Transmembrane 9 superfamily member 4 OS=Pongo abelii GN=TM9SF4 PE=2 SV=1 PF01445//PF02990 Viral small hydrophobic protein//Endomembrane protein 70 -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.30267 BF_2 41.04 0.52 3610 91088055 XP_967186.1 1525 3.4e-166 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 111 3.23347e-48 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q2NL29 1296 5.1e-141 Inositol-3-phosphate synthase 1 OS=Bos taurus GN=ISYNA1 PE=2 SV=1 PF13912//PF07994//PF13762 C2H2-type zinc finger//Myo-inositol-1-phosphate synthase//Mitochondrial splicing apparatus component GO:0006021//GO:0000372//GO:0019872//GO:0008654 inositol biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//phospholipid biosynthetic process GO:0046872//GO:0004512//GO:0000166 metal ion binding//inositol-3-phosphate synthase activity//nucleotide binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.30268 BF_2 2875.12 43.93 3025 91088055 XP_967186.1 2083 5.7e-231 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 138 2.64742e-63 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q7ZXY0 1709 5.5e-189 Inositol-3-phosphate synthase 1-A OS=Xenopus laevis GN=isyna1-a PE=2 SV=1 PF13762//PF07994//PF13912 Mitochondrial splicing apparatus component//Myo-inositol-1-phosphate synthase//C2H2-type zinc finger GO:0008654//GO:0000372//GO:0019872//GO:0006021 phospholipid biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//inositol biosynthetic process GO:0000166//GO:0004512//GO:0046872 nucleotide binding//inositol-3-phosphate synthase activity//metal ion binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.30271 BF_2 1723.04 4.36 16820 270001730 EEZ98177.1 6767 0.0e+00 hypothetical protein TcasGA2_TC000606 [Tribolium castaneum] 807039419 XM_004534701.2 145 1.90805e-66 PREDICTED: Ceratitis capitata histone-lysine N-methyltransferase trr (LOC101450744), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1972 9.7e-219 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF00856//PF05965//PF00628//PF07155//PF05964 SET domain//F/Y rich C-terminus//PHD-finger//ECF-type riboflavin transporter, S component//F/Y-rich N-terminus -- -- GO:0005515 protein binding GO:0016020//GO:0005634 membrane//nucleus KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.30272 BF_2 1513.00 24.93 2826 642933328 XP_969796.2 1081 8.2e-115 PREDICTED: glucose-induced degradation protein 4 homolog [Tribolium castaneum] 170048717 XM_001870712.1 115 1.50845e-50 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8IVV7 887 1.1e-93 Glucose-induced degradation protein 4 homolog OS=Homo sapiens GN=GID4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4635 Vacuolar import and degradation protein Cluster-8309.30274 BF_2 3.00 0.32 677 642927984 XP_008195472.1 338 2.8e-29 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30279 BF_2 743.00 14.14 2485 91095021 XP_970287.1 743 1.1e-75 PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|642939790|ref|XP_008193677.1| PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|642939793|ref|XP_008193686.1| PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|642939795|ref|XP_008193689.1| PREDICTED: RING finger protein 11 [Tribolium castaneum]>gi|270015434|gb|EFA11882.1| hypothetical protein TcasGA2_TC004296 [Tribolium castaneum] -- -- -- -- -- K11980 RNF11 E3 ubiquitin-protein ligase RNF11 http://www.genome.jp/dbget-bin/www_bget?ko:K11980 Q08DI6 520 3.3e-51 RING finger protein 11 OS=Bos taurus GN=RNF11 PE=2 SV=1 PF13639//PF00097//PF01021//PF12861//PF14634//PF12678//PF17123 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//TYA transposon protein//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//RING-H2 zinc finger//RING-like zinc finger GO:0016567 protein ubiquitination GO:0003723//GO:0004842//GO:0005515//GO:0008270//GO:0046872 RNA binding//ubiquitin-protein transferase activity//protein binding//zinc ion binding//metal ion binding GO:0005680//GO:0005737 anaphase-promoting complex//cytoplasm KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.30280 BF_2 15.22 0.34 2185 156553608 XP_001599867.1 425 7.4e-39 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Nasonia vitripennis] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q9D2Y9 316 1.3e-27 Elongation of very long chain fatty acids protein 7 OS=Mus musculus GN=Elovl7 PE=2 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.30281 BF_2 1184.37 18.19 3011 478263377 ENN81749.1 1019 1.4e-107 hypothetical protein YQE_01842, partial [Dendroctonus ponderosae] 642918138 XM_008193161.1 274 6.58872e-139 PREDICTED: Tribolium castaneum hepatic leukemia factor-like (LOC655431), partial mRNA K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 418 2.7e-39 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF09726//PF03131//PF00170//PF07716 Transmembrane protein//bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634//GO:0016021 transcription factor complex//nucleus//integral component of membrane KOG3119 Basic region leucine zipper transcription factor Cluster-8309.30284 BF_2 367.58 57.83 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30286 BF_2 12.25 1.01 793 642931489 XP_008196607.1 358 1.6e-31 PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931491|ref|XP_967441.2| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931493|ref|XP_008196608.1| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum] 572309161 XM_006620318.1 61 4.28426e-21 PREDICTED: Apis dorsata nitrogen permease regulator 2-like protein-like (LOC102670637), transcript variant X2, mRNA -- -- -- -- Q9WUE4 206 2.7e-15 Nitrogen permease regulator 2-like protein OS=Mus musculus GN=Nprl2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30287 BF_2 166.65 5.03 1673 642931489 XP_008196607.1 1654 1.8e-181 PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931491|ref|XP_967441.2| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum]>gi|642931493|ref|XP_008196608.1| PREDICTED: nitrogen permease regulator 2-like protein [Tribolium castaneum] 572309161 XM_006620318.1 113 1.14596e-49 PREDICTED: Apis dorsata nitrogen permease regulator 2-like protein-like (LOC102670637), transcript variant X2, mRNA -- -- -- -- Q5E9U9 960 2.1e-102 Nitrogen permease regulator 2-like protein OS=Bos taurus GN=NPRL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3789 Nitrogen permease regulator NLRG/NPR2 Cluster-8309.30288 BF_2 11.00 2.29 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30290 BF_2 20.81 0.35 2782 546671642 ERL83869.1 240 2.7e-17 hypothetical protein D910_01137 [Dendroctonus ponderosae]>gi|546671873|gb|ERL83994.1| hypothetical protein D910_01311 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09293 T4 RNase H, C terminal -- -- GO:0003677//GO:0003824 DNA binding//catalytic activity -- -- -- -- Cluster-8309.30292 BF_2 815.12 3.49 10071 642912009 XP_008199058.1 2159 2.9e-239 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X1 [Tribolium castaneum]>gi|270014484|gb|EFA10932.1| hypothetical protein TcasGA2_TC001759 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PE2 1043 3.1e-111 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 PF03185//PF01020//PF00621//PF01007 Calcium-activated potassium channel, beta subunit//Ribosomal L40e family//RhoGEF domain//Inward rectifier potassium channel GO:0043087//GO:0042254//GO:0035023//GO:0006813//GO:0006412 regulation of GTPase activity//ribosome biogenesis//regulation of Rho protein signal transduction//potassium ion transport//translation GO:0003735//GO:0005089//GO:0005242//GO:0015269 structural constituent of ribosome//Rho guanyl-nucleotide exchange factor activity//inward rectifier potassium channel activity//calcium-activated potassium channel activity GO:0005840//GO:0016020//GO:0005622//GO:0008076//GO:0016021 ribosome//membrane//intracellular//voltage-gated potassium channel complex//integral component of membrane KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.30294 BF_2 94.12 0.78 5366 642912011 XP_008199059.1 1160 1.1e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05373//PF02892 L-proline 3-hydroxylase, C-terminal//BED zinc finger GO:0055114 oxidation-reduction process GO:0016706//GO:0003677 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//DNA binding -- -- -- -- Cluster-8309.30298 BF_2 273.05 35.71 607 194889650 XP_001977128.1 676 1.6e-68 GG18414 [Drosophila erecta]>gi|190648777|gb|EDV46055.1| GG18414 [Drosophila erecta] 755966671 XM_011307276.1 101 1.87893e-43 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X10, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 552 1.6e-55 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.30299 BF_2 223.00 5.53 1975 546673345 ERL84971.1 868 2.9e-90 hypothetical protein D910_02394 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q91W39 329 3.7e-29 Nuclear receptor coactivator 5 OS=Mus musculus GN=Ncoa5 PE=1 SV=1 PF00076//PF08675 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0046872//GO:0003676//GO:0004535 RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.303 BF_2 17.00 0.41 2018 766932491 XP_011498465.1 280 4.5e-22 PREDICTED: probable cyclin-dependent serine/threonine-protein kinase DDB_G0292550 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.30300 BF_2 78.00 0.93 3791 642923421 XP_008193737.1 1737 9.4e-191 PREDICTED: uncharacterized protein LOC103313112 [Tribolium castaneum]>gi|270008224|gb|EFA04672.1| hypothetical protein TcasGA2_TC014328 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06308 23S rRNA methylase leader peptide (ErmC) GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.30302 BF_2 1.00 0.93 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30303 BF_2 218.43 7.41 1520 642931807 XP_008196739.1 1528 6.5e-167 PREDICTED: uncharacterized protein LOC658297 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCX1 145 6.2e-08 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30304 BF_2 1.00 5.30 251 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30305 BF_2 426.84 3.76 5033 642917385 XP_008199669.1 1771 1.4e-194 PREDICTED: uncharacterized protein LOC658463 [Tribolium castaneum]>gi|270003013|gb|EEZ99460.1| hypothetical protein TcasGA2_TC000026 [Tribolium castaneum] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 8.0e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF05271//PF05019 Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006744//GO:0019089 ubiquinone biosynthetic process//transmission of virus -- -- -- -- KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.30306 BF_2 19.00 3.01 551 817078679 XP_012261722.1 184 1.6e-11 PREDICTED: longitudinals lacking protein, isoform G isoform X25 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF01428 Zinc finger, C2H2 type//Zinc-finger double domain//AN1-like Zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.30307 BF_2 50.94 1.22 2028 91089699 XP_974834.1 1182 1.1e-126 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum]>gi|270011321|gb|EFA07769.1| hypothetical protein TcasGA2_TC005323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 173 4.7e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF00856//PF13414 SET domain//TPR repeat -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.30308 BF_2 3.00 0.93 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30309 BF_2 799.99 7.68 4643 91081241 XP_975643.1 1992 3.1e-220 PREDICTED: interference hedgehog-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 861 1.8e-90 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF13895//PF00041//PF16656//PF02480 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0016020 membrane -- -- Cluster-8309.3031 BF_2 8.00 0.36 1217 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30311 BF_2 28.04 0.43 3037 478262421 ENN81092.1 670 4.0e-67 hypothetical protein YQE_02460, partial [Dendroctonus ponderosae]>gi|546673642|gb|ERL85206.1| hypothetical protein D910_02627 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF05261 THAP domain//TraM protein, DNA-binding GO:0000746 conjugation GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.30313 BF_2 432.00 15.81 1430 642911124 XP_008200590.1 706 1.3e-71 PREDICTED: peflin [Tribolium castaneum]>gi|270014674|gb|EFA11122.1| hypothetical protein TcasGA2_TC004722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UBV8 385 8.7e-36 Peflin OS=Homo sapiens GN=PEF1 PE=1 SV=1 PF13202//PF13499//PF13405//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.30315 BF_2 606.00 7.05 3883 91093266 XP_971119.1 4978 0.0e+00 PREDICTED: membrane-associated protein Hem [Tribolium castaneum]>gi|270016828|gb|EFA13274.1| Hem [Tribolium castaneum] 462292279 APGK01053803.1 446 0 Dendroctonus ponderosae Seq01053813, whole genome shotgun sequence K05750 NCKAP1, NAP125 NCK-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05750 P55162 4212 0.0e+00 Membrane-associated protein Hem OS=Drosophila melanogaster GN=Hem PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1917 Membrane-associated hematopoietic protein Cluster-8309.30317 BF_2 304.57 3.36 4083 149588751 NP_001092296.1 2699 2.9e-302 fused lobes [Tribolium castaneum]>gi|642928772|ref|XP_008195555.1| PREDICTED: fused lobes isoform X1 [Tribolium castaneum]>gi|148611482|gb|ABQ95985.1| beta-N-acetylglucosaminidase FDL [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 1351 2.4e-147 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0001575//GO:0006027//GO:0005975//GO:0006040 globoside metabolic process//glycosaminoglycan catabolic process//carbohydrate metabolic process//amino sugar metabolic process GO:0004553//GO:0043169//GO:0004563 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//beta-N-acetylhexosaminidase activity -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.30318 BF_2 893.18 11.56 3518 91087975 XP_973241.1 1156 2.1e-123 PREDICTED: wiskott-Aldrich syndrome protein family member 3 [Tribolium castaneum]>gi|270012052|gb|EFA08500.1| hypothetical protein TcasGA2_TC006152 [Tribolium castaneum] -- -- -- -- -- K06220 WASF WAS protein family http://www.genome.jp/dbget-bin/www_bget?ko:K06220 Q9UPY6 478 3.5e-46 Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens GN=WASF3 PE=1 SV=2 PF03358//PF02205//PF07415 NADPH-dependent FMN reductase//WH2 motif//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0003779//GO:0016491 actin binding//oxidoreductase activity GO:0033644 host cell membrane KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.30319 BF_2 2535.00 37.94 3082 642916521 XP_008191077.1 3677 0.0e+00 PREDICTED: neutral alpha-glucosidase AB isoform X1 [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q8BHN3 2247 2.3e-251 Neutral alpha-glucosidase AB OS=Mus musculus GN=Ganab PE=1 SV=1 PF04049//PF01055 Anaphase promoting complex subunit 8 / Cdc23//Glycosyl hydrolases family 31 GO:0005975//GO:0030071 carbohydrate metabolic process//regulation of mitotic metaphase/anaphase transition GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005680 anaphase-promoting complex KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.30320 BF_2 87.10 1.88 2230 270014846 EFA11294.1 1725 1.4e-189 hypothetical protein TcasGA2_TC010831 [Tribolium castaneum] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 P41239 1033 9.8e-111 Tyrosine-protein kinase CSK OS=Gallus gallus GN=CSK PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.30322 BF_2 1565.73 37.86 2017 270013857 EFA10305.1 162 2.2e-08 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03529 Otx1 transcription factor GO:0007275 multicellular organismal development GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.30324 BF_2 4.00 0.75 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30328 BF_2 10.00 1.98 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30329 BF_2 54.63 0.96 2664 270001480 EEZ97927.1 1023 4.1e-108 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M3K2 412 1.2e-38 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF01025 GrpE GO:0006457 protein folding GO:0000774//GO:0042803//GO:0051087 adenyl-nucleotide exchange factor activity//protein homodimerization activity//chaperone binding -- -- -- -- Cluster-8309.30330 BF_2 51.65 0.98 2494 795029505 XP_011862965.1 792 2.4e-81 PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi]>gi|795029508|ref|XP_011862966.1| PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi]>gi|795029511|ref|XP_011862967.1| PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi]>gi|795029514|ref|XP_011862968.1| PREDICTED: uncharacterized protein LOC105559356 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 232 8.3e-18 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30331 BF_2 54.91 2.17 1347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30332 BF_2 6.09 0.34 1028 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30334 BF_2 139.25 2.75 2408 531445261 AGT57839.1 675 8.4e-68 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 388 6.6e-36 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.30335 BF_2 26.00 19.31 337 531445261 AGT57839.1 323 7.7e-28 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V6D6 273 2.0e-23 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.30336 BF_2 329.88 6.24 2497 531445261 AGT57839.1 756 3.5e-77 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 Q9VE01 534 8.0e-53 Probable cytochrome P450 12a5, mitochondrial OS=Drosophila melanogaster GN=Cyp12a5 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.30337 BF_2 116.04 12.78 667 642928567 XP_008199961.1 583 1.1e-57 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 478 6.7e-47 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30342 BF_2 468.38 11.51 1989 189236494 XP_001816015.1 970 4.3e-102 PREDICTED: uncharacterized protein LOC100142441 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12337 MRVI1, IRAG inositol 1,4,5-triphosphate receptor-associated cGMP kinase substrate http://www.genome.jp/dbget-bin/www_bget?ko:K12337 Q5RHB5 170 1.0e-10 Lymphoid-restricted membrane protein OS=Danio rerio GN=lrmp PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30344 BF_2 7.00 0.77 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30345 BF_2 47.05 0.32 6400 478256055 ENN76254.1 1530 1.6e-166 hypothetical protein YQE_07219, partial [Dendroctonus ponderosae] -- -- -- -- -- K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 412 2.9e-38 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF17095 Spectrin-binding region of Ca2+-Calmodulin GO:0031175 neuron projection development GO:0005516//GO:0030507 calmodulin binding//spectrin binding GO:0008091 spectrin -- -- Cluster-8309.30346 BF_2 820.24 29.84 1437 642916928 XP_008199558.1 1741 1.2e-191 PREDICTED: actin-related protein 2/3 complex subunit 1A isoform X2 [Tribolium castaneum] 332376918 BT128642.1 178 7.21613e-86 Dendroctonus ponderosae clone DPO1115_K05 unknown mRNA K05757 ARPC1A_B actin related protein 2/3 complex, subunit 1A/1B http://www.genome.jp/dbget-bin/www_bget?ko:K05757 Q9R0Q6 1232 5.3e-134 Actin-related protein 2/3 complex subunit 1A OS=Mus musculus GN=Arpc1a PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1523 Actin-related protein Arp2/3 complex, subunit ARPC1/p41-ARC Cluster-8309.30348 BF_2 989.49 12.50 3598 642931661 XP_008196677.1 2801 0.0e+00 PREDICTED: rap1 GTPase-activating protein 1 isoform X5 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.17558e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 3.2e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF09726//PF07836//PF02145 Transmembrane protein//DmpG-like communication domain//Rap/ran-GAP GO:0019439//GO:0051056 aromatic compound catabolic process//regulation of small GTPase mediated signal transduction GO:0016833//GO:0005096 oxo-acid-lyase activity//GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.30349 BF_2 90.51 1.80 2389 270001544 EEZ97991.1 156 1.3e-07 hypothetical protein TcasGA2_TC000388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30350 BF_2 517.95 2.07 10756 642914280 XP_008201619.1 1367 2.1e-147 PREDICTED: cyclic AMP-dependent transcription factor ATF-6 beta [Tribolium castaneum] 332375533 BT127946.1 81 4.60724e-31 Dendroctonus ponderosae clone DPO1025_H21 unknown mRNA K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q6GM78 703 8.7e-72 Isoaspartyl peptidase/L-asparaginase OS=Xenopus laevis GN=asrgl1 PE=2 SV=1 PF04977//PF04275//PF16866//PF07776//PF14861//PF01112//PF13465//PF03453//PF06156//PF03604//PF00170//PF00096//PF06005//PF01363//PF13912//PF03131//PF01166//PF07716//PF12356//PF07975 Septum formation initiator//Phosphomevalonate kinase//PHD-finger//Zinc-finger associated domain (zf-AD)//Plant antimicrobial peptide//Asparaginase//Zinc-finger double domain//MoeA N-terminal region (domain I and II)//Protein of unknown function (DUF972)//DNA directed RNA polymerase, 7 kDa subunit//bZIP transcription factor//Zinc finger, C2H2 type//Protein of unknown function (DUF904)//FYVE zinc finger//C2H2-type zinc finger//bZIP Maf transcription factor//TSC-22/dip/bun family//Basic region leucine zipper//Protein of unknown function (DUF3643)//TFIIH C1-like domain GO:0006144//GO:0016567//GO:0006351//GO:0032324//GO:0006695//GO:0000917//GO:0043093//GO:0006206//GO:0032465//GO:0006281//GO:0050832//GO:0007049//GO:0006694//GO:0006915//GO:0006355//GO:0006260 purine nucleobase metabolic process//protein ubiquitination//transcription, DNA-templated//molybdopterin cofactor biosynthetic process//cholesterol biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//pyrimidine nucleobase metabolic process//regulation of cytokinesis//DNA repair//defense response to fungus//cell cycle//steroid biosynthetic process//apoptotic process//regulation of transcription, DNA-templated//DNA replication GO:0004842//GO:0005515//GO:0003677//GO:0046872//GO:0003899//GO:0016787//GO:0003700//GO:0004631//GO:0043565//GO:0008270 ubiquitin-protein transferase activity//protein binding//DNA binding//metal ion binding//DNA-directed RNA polymerase activity//hydrolase activity//transcription factor activity, sequence-specific DNA binding//phosphomevalonate kinase activity//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634//GO:0005737//GO:0005730 transcription factor complex//nucleus//cytoplasm//nucleolus KOG1592 Asparaginase Cluster-8309.30354 BF_2 325.28 3.41 4272 755874784 XP_011292472.1 2373 1.9e-264 PREDICTED: E3 ubiquitin-protein ligase Nedd-4 isoform X4 [Musca domestica] -- -- -- -- -- K10591 NEDD4, RSP5 E3 ubiquitin-protein ligase NEDD4 http://www.genome.jp/dbget-bin/www_bget?ko:K10591 Q9VVI3 2157 8.7e-241 E3 ubiquitin-protein ligase Nedd-4 OS=Drosophila melanogaster GN=Nedd4 PE=1 SV=2 PF00632//PF00397//PF00168 HECT-domain (ubiquitin-transferase)//WW domain//C2 domain GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.30355 BF_2 145.00 8.72 983 478261092 ENN80647.1 349 2.2e-30 hypothetical protein YQE_02934, partial [Dendroctonus ponderosae]>gi|546679162|gb|ERL89664.1| hypothetical protein D910_07027 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14978//PF01612 Mitochondrial ribosome protein 63//3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding GO:0005761 mitochondrial ribosome -- -- Cluster-8309.30358 BF_2 5.93 0.40 915 780114121 XP_011676955.1 368 1.3e-32 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 328 2.3e-29 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF08052 Ankyrin repeat//Ankyrin repeat//PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process GO:0005515 protein binding -- -- -- -- Cluster-8309.30359 BF_2 4.00 1.17 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30360 BF_2 218.69 2.89 3458 270007492 EFA03940.1 4135 0.0e+00 hypothetical protein TcasGA2_TC014081 [Tribolium castaneum] -- -- -- -- -- K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1972 2.0e-219 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF04625//PF11547 DEC-1 protein, N-terminal region//E3 ubiquitin ligase EDD GO:0007304 chorion-containing eggshell formation GO:0005213//GO:0043130 structural constituent of chorion//ubiquitin binding GO:0005576//GO:0042600 extracellular region//chorion KOG0943 Predicted ubiquitin-protein ligase/hyperplastic discs protein, HECT superfamily Cluster-8309.30361 BF_2 21.00 1.51 870 270004579 EFA01027.1 154 7.9e-08 hypothetical protein TcasGA2_TC003942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30362 BF_2 370.00 17.86 1154 189239253 XP_001807041.1 810 8.9e-84 PREDICTED: uncharacterized protein LOC100141764 [Tribolium castaneum]>gi|270010382|gb|EFA06830.1| hypothetical protein TcasGA2_TC009773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30364 BF_2 74.31 0.55 5988 642932082 XP_008196850.1 2434 2.2e-271 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 1037 9.1e-111 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 PF13912//PF08465//PF00096//PF13465 C2H2-type zinc finger//Thymidine kinase from Herpesvirus C-terminal//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006230 pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0005524//GO:0004797//GO:0046872 ATP binding//thymidine kinase activity//metal ion binding -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.30367 BF_2 224.93 0.89 10903 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.3037 BF_2 4.58 1.46 418 642933160 XP_008197281.1 357 1.1e-31 PREDICTED: ubiquitin carboxyl-terminal hydrolase nonstop isoform X1 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q6GNI6 248 1.9e-20 Ubiquitin carboxyl-terminal hydrolase 22-A OS=Xenopus laevis GN=usp22-a PE=2 SV=1 PF15499//PF00443 Ubiquitin-specific peptidase-like, SUMO isopeptidase//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0070140//GO:0032183//GO:0036459 SUMO-specific isopeptidase activity//SUMO binding//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.30370 BF_2 8.93 0.43 1151 642931035 XP_008196187.1 199 6.3e-13 PREDICTED: uncharacterized protein LOC103313793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00520//PF06305 Ion transport protein//Protein of unknown function (DUF1049) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.30371 BF_2 6.00 0.31 1097 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30373 BF_2 35.00 0.32 4920 642926858 XP_008195042.1 222 5.8e-15 PREDICTED: RIMS-binding protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09606 ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.30376 BF_2 3320.53 48.52 3150 283046718 NP_001164305.1 2081 1.0e-230 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 432 0 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q91YT0 1897 9.0e-211 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 PF10589 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GO:0006120//GO:0006744//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//proton transport//oxidation-reduction process GO:0010181//GO:0051287//GO:0008137//GO:0051539 FMN binding//NAD binding//NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.30377 BF_2 602.39 4.82 5517 283046718 NP_001164305.1 2081 1.8e-230 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 432 0 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q91YT0 1897 1.6e-210 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 PF04177//PF10589 TAP42-like family//NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GO:0006120//GO:0009966//GO:0006744//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//regulation of signal transduction//ubiquinone biosynthetic process//sodium ion transport//proton transport//oxidation-reduction process GO:0010181//GO:0051287//GO:0008137//GO:0051539 FMN binding//NAD binding//NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.30378 BF_2 33.41 1.76 1081 91094163 XP_970089.1 440 6.7e-41 PREDICTED: neuralized-like protein 2 [Tribolium castaneum]>gi|270010902|gb|EFA07350.1| hypothetical protein TcasGA2_TC015949 [Tribolium castaneum] -- -- -- -- -- K16782 NEURL2 neuralized-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16782 Q9D0S4 188 4.6e-13 Neuralized-like protein 2 OS=Mus musculus GN=Neurl2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- GO:0005622 intracellular -- -- Cluster-8309.30379 BF_2 85.89 2.56 1692 332374134 AEE62208.1 733 1.1e-74 unknown [Dendroctonus ponderosae]>gi|478257958|gb|ENN78096.1| hypothetical protein YQE_05250, partial [Dendroctonus ponderosae]>gi|546676502|gb|ERL87500.1| hypothetical protein D910_04892 [Dendroctonus ponderosae] -- -- -- -- -- K16782 NEURL2 neuralized-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16782 Q9D0S4 382 2.3e-35 Neuralized-like protein 2 OS=Mus musculus GN=Neurl2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.30380 BF_2 13.68 0.38 1806 642924614 XP_008194364.1 608 3.7e-60 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30386 BF_2 14.00 1.23 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30387 BF_2 59.32 0.82 3323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30388 BF_2 152.00 2.02 3429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30390 BF_2 483.00 11.60 2029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane -- -- Cluster-8309.30391 BF_2 365.56 21.13 1011 642911665 XP_969599.2 616 2.4e-61 PREDICTED: uncharacterized protein C45G9.7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09506 313 1.4e-27 Uncharacterized protein C45G9.7 OS=Caenorhabditis elegans GN=C45G9.7 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3553 Tax interaction protein TIP1 Cluster-8309.30392 BF_2 18.56 0.62 1539 642911665 XP_969599.2 311 8.6e-26 PREDICTED: uncharacterized protein C45G9.7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09506 182 3.2e-12 Uncharacterized protein C45G9.7 OS=Caenorhabditis elegans GN=C45G9.7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3553 Tax interaction protein TIP1 Cluster-8309.30393 BF_2 285.00 10.73 1398 478252105 ENN72536.1 459 5.4e-43 hypothetical protein YQE_10876, partial [Dendroctonus ponderosae]>gi|546683902|gb|ERL93650.1| hypothetical protein D910_10938 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30395 BF_2 99.00 3.64 1426 642922021 XP_008192988.1 358 2.8e-31 PREDICTED: adult-specific cuticular protein ACP-20-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26967 360 6.9e-33 Adult-specific cuticular protein ACP-20 OS=Tenebrio molitor GN=ACP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30396 BF_2 687.16 5.57 5446 642927078 XP_008195127.1 1453 1.2e-157 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 1038 6.3e-111 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF00001//PF02742//PF00002 7 transmembrane receptor (rhodopsin family)//Iron dependent repressor, metal binding and dimerisation domain//7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0046914//GO:0046983 G-protein coupled receptor activity//transition metal ion binding//protein dimerization activity GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.30398 BF_2 1111.33 52.96 1165 91094297 XP_971720.1 1187 1.7e-127 PREDICTED: estradiol 17-beta-dehydrogenase 12 [Tribolium castaneum]>gi|270014405|gb|EFA10853.1| hypothetical protein TcasGA2_TC001630 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q28IU1 690 3.0e-71 Very-long-chain 3-oxoacyl-CoA reductase OS=Xenopus tropicalis GN=hsd17b12 PE=2 SV=1 PF02882//PF00106//PF02737//PF03435//PF01370 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0046487//GO:0009396//GO:0006574//GO:0006550//GO:0055114//GO:0006554//GO:0006568//GO:0008152//GO:0006633//GO:0018874//GO:0006552//GO:0006631 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//valine catabolic process//isoleucine catabolic process//oxidation-reduction process//lysine catabolic process//tryptophan metabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process GO:0004488//GO:0050662//GO:0003857//GO:0000166//GO:0016491//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//coenzyme binding//3-hydroxyacyl-CoA dehydrogenase activity//nucleotide binding//oxidoreductase activity//catalytic activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.30399 BF_2 335.21 13.12 1356 91089719 XP_974982.1 1687 2.1e-185 PREDICTED: methyltransferase-like protein 14 homolog [Tribolium castaneum]>gi|270012642|gb|EFA09090.1| hypothetical protein TcasGA2_TC006811 [Tribolium castaneum] 768446739 XM_011567022.1 116 1.98641e-51 PREDICTED: Plutella xylostella methyltransferase-like protein 14 homolog (LOC105395098), mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q9VLP7 1399 2.2e-153 Methyltransferase-like protein 14 homolog OS=Drosophila melanogaster GN=CG7818 PE=2 SV=1 PF05063 MT-A70 GO:0032259//GO:0006139 methylation//nucleobase-containing compound metabolic process GO:0008168 methyltransferase activity -- -- KOG2097 Predicted N6-adenine methylase involved in transcription regulation Cluster-8309.30400 BF_2 59.00 30.50 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30401 BF_2 27.97 1.26 1213 642922794 XP_008193328.1 508 9.8e-49 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 1.9e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF08612//PF00322 TATA-binding related factor (TRF) of subunit 20 of Mediator complex//Endothelin family GO:0019229//GO:0006357 regulation of vasoconstriction//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005576 mediator complex//extracellular region -- -- Cluster-8309.30402 BF_2 535.00 9.75 2583 478251189 ENN71665.1 2418 6.9e-270 hypothetical protein YQE_11763, partial [Dendroctonus ponderosae] -- -- -- -- -- K03419 CHPF2 chondroitin polymerizing factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03419 Q6IQX7 665 5.3e-68 Chondroitin sulfate synthase 2 OS=Mus musculus GN=Chpf PE=1 SV=1 PF05679//PF03526 Chondroitin N-acetylgalactosaminyltransferase//Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0008376//GO:0015643 acetylgalactosaminyltransferase activity//toxic substance binding GO:0019814//GO:0032580 immunoglobulin complex//Golgi cisterna membrane KOG3708 Uncharacterized conserved protein Cluster-8309.30403 BF_2 176.00 6.45 1429 91080237 XP_972872.1 450 6.1e-42 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30406 BF_2 11.70 0.49 1281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30408 BF_2 15.00 0.36 2028 817062861 XP_012253104.1 1124 6.1e-120 PREDICTED: protein gustavus [Athalia rosae] 395519288 XM_003763735.1 113 1.39433e-49 PREDICTED: Sarcophilus harrisii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1058 1.1e-113 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF00622//PF07525 SPRY domain//SOCS box GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.30409 BF_2 1553.00 83.74 1063 91095009 XP_969881.1 670 1.4e-67 PREDICTED: translocon-associated protein subunit gamma [Tribolium castaneum]>gi|270015431|gb|EFA11879.1| hypothetical protein TcasGA2_TC004293 [Tribolium castaneum] 769843857 XM_011634857.1 98 1.56987e-41 PREDICTED: Pogonomyrmex barbatus translocon-associated protein subunit gamma (LOC105424561), mRNA K13251 SSR3 translocon-associated protein subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K13251 Q9UNL2 502 1.8e-49 Translocon-associated protein subunit gamma OS=Homo sapiens GN=SSR3 PE=1 SV=1 PF05298//PF15048//PF07074 Bombinin//Organic solute transporter subunit beta protein//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006810//GO:0015721//GO:0006613//GO:0042742 transport//bile acid and bile salt transport//cotranslational protein targeting to membrane//defense response to bacterium GO:0005215//GO:0046982 transporter activity//protein heterodimerization activity GO:0005784//GO:0030176//GO:0005886//GO:0005576 Sec61 translocon complex//integral component of endoplasmic reticulum membrane//plasma membrane//extracellular region KOG4490 Translocon-associated complex TRAP, gamma subunit Cluster-8309.30410 BF_2 186.75 1.09 7457 642939202 XP_008200380.1 3478 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 167 4.97226e-79 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1288 8.9e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF00002//PF02617//PF02140//PF01825//PF02793 Membrane transport protein//7 transmembrane receptor (Secretin family)//ATP-dependent Clp protease adaptor protein ClpS//Galactose binding lectin domain//GPCR proteolysis site, GPS, motif//Hormone receptor domain GO:0030163//GO:0007186//GO:0055085 protein catabolic process//G-protein coupled receptor signaling pathway//transmembrane transport GO:0030246//GO:0004930 carbohydrate binding//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG4193 G protein-coupled receptors Cluster-8309.30411 BF_2 30.10 0.52 2694 270007885 EFA04333.1 652 4.4e-65 hypothetical protein TcasGA2_TC014627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7K0 382 3.6e-35 Inactive hydroxysteroid dehydrogenase-like protein 1 OS=Pongo abelii GN=HSDL1 PE=2 SV=1 PF00709//PF00106//PF02737//PF01356//PF12242 Adenylosuccinate synthetase//short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Alpha amylase inhibitor//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0006531//GO:0006144//GO:0018874//GO:0006633//GO:0008152//GO:0006552//GO:0006522//GO:0006631//GO:0006164//GO:0006550//GO:0006574//GO:0055114//GO:0006554//GO:0006568 aspartate metabolic process//purine nucleobase metabolic process//benzoate metabolic process//fatty acid biosynthetic process//metabolic process//leucine catabolic process//alanine metabolic process//fatty acid metabolic process//purine nucleotide biosynthetic process//isoleucine catabolic process//valine catabolic process//oxidation-reduction process//lysine catabolic process//tryptophan metabolic process GO:0016491//GO:0005525//GO:0004019//GO:0003857//GO:0015066 oxidoreductase activity//GTP binding//adenylosuccinate synthase activity//3-hydroxyacyl-CoA dehydrogenase activity//alpha-amylase inhibitor activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.30412 BF_2 499.12 17.89 1454 478259232 ENN79134.1 2074 3.0e-230 hypothetical protein YQE_04320, partial [Dendroctonus ponderosae] 462360259 APGK01029452.1 244 1.49397e-122 Dendroctonus ponderosae Seq01029462, whole genome shotgun sequence K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 Q95ZS2 1542 6.1e-170 Tyrosine decarboxylase OS=Caenorhabditis elegans GN=tdc-1 PE=2 SV=1 PF04655//PF00282 Aminoglycoside/hydroxyurea antibiotic resistance kinase//Pyridoxal-dependent decarboxylase conserved domain GO:0019748//GO:0006468//GO:0019752 secondary metabolic process//protein phosphorylation//carboxylic acid metabolic process GO:0016773//GO:0016831//GO:0030170 phosphotransferase activity, alcohol group as acceptor//carboxy-lyase activity//pyridoxal phosphate binding -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.30413 BF_2 52.00 0.42 5435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30417 BF_2 5772.74 70.28 3723 546673598 ERL85162.1 1169 6.8e-125 hypothetical protein D910_02584, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 279 4.4e-23 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30418 BF_2 1442.19 26.24 2586 91087843 XP_968073.1 1529 8.5e-167 PREDICTED: ceramide synthase 6-like [Tribolium castaneum] 347966517 XM_321321.5 153 1.03679e-71 Anopheles gambiae str. PEST AGAP001761-PA (AgaP_AGAP001761) mRNA, complete cds K04710 CERS ceramide synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K04710 Q8C172 760 5.2e-79 Ceramide synthase 6 OS=Mus musculus GN=Cers6 PE=1 SV=1 PF03798//PF12766//PF00046 TLC domain//Pyridoxamine 5'-phosphate oxidase//Homeobox domain -- -- GO:0003677//GO:0010181 DNA binding//FMN binding GO:0016021 integral component of membrane KOG1607 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.30419 BF_2 427.00 6.51 3030 189233641 XP_001814986.1 2204 5.3e-245 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 817217362 XM_012429207.1 113 2.09398e-49 PREDICTED: Orussus abietinus nicotinate phosphoribosyltransferase (LOC105702012), transcript variant X3, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2042 1.3e-227 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF02749 Quinolinate phosphoribosyl transferase, N-terminal domain -- -- GO:0016763 transferase activity, transferring pentosyl groups -- -- KOG2511 Nicotinic acid phosphoribosyltransferase Cluster-8309.30420 BF_2 33.78 0.46 3379 642927450 XP_008195278.1 715 2.7e-72 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X2 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 360 1.6e-32 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF07650//PF00013//PF13184//PF13014 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.30422 BF_2 1178.92 14.57 3671 642911714 XP_008200711.1 876 6.3e-91 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 704 2.3e-72 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.30423 BF_2 1256.00 14.00 4041 91083057 XP_966898.1 5003 0.0e+00 PREDICTED: cohesin subunit SA-1 [Tribolium castaneum] 815802185 XM_012366342.1 297 1.45307e-151 PREDICTED: Linepithema humile cohesin subunit SA-2 (LOC105671847), mRNA K06671 STAG1_2, SCC3, IRR1 cohesin complex subunit SA-1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K06671 Q8WVM7 2531 3.5e-284 Cohesin subunit SA-1 OS=Homo sapiens GN=STAG1 PE=1 SV=3 PF09236//PF00858 Alpha-haemoglobin stabilising protein//Amiloride-sensitive sodium channel GO:0006814//GO:0020027//GO:0030097//GO:0006457//GO:0050821 sodium ion transport//hemoglobin metabolic process//hemopoiesis//protein folding//protein stabilization GO:0005272//GO:0030492 sodium channel activity//hemoglobin binding GO:0016020//GO:0005833 membrane//hemoglobin complex KOG2011 Sister chromatid cohesion complex Cohesin, subunit STAG/IRR1/SCC3 Cluster-8309.30424 BF_2 16.72 0.70 1290 91078580 XP_971846.1 727 4.2e-74 PREDICTED: UDP-N-acetylglucosamine transferase subunit ALG14 homolog [Tribolium castaneum]>gi|270004042|gb|EFA00490.1| hypothetical protein TcasGA2_TC003350 [Tribolium castaneum] -- -- -- -- -- K07441 ALG14 beta-1,4-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07441 Q9D081 457 3.5e-44 UDP-N-acetylglucosamine transferase subunit ALG14 homolog OS=Mus musculus GN=Alg14 PE=2 SV=1 PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0005634//GO:0000775 nucleus//chromosome, centromeric region KOG3339 Predicted glycosyltransferase Cluster-8309.30426 BF_2 14.48 0.33 2133 642937495 XP_008198863.1 171 2.1e-09 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30427 BF_2 252.00 4.95 2415 189238877 XP_973702.2 2065 5.6e-229 PREDICTED: transcription factor IIIB 90 kDa subunit [Tribolium castaneum] 645033290 XM_008216720.1 92 7.85724e-38 PREDICTED: Nasonia vitripennis transcription factor IIIB 90 kDa subunit (LOC100123706), transcript variant X4, mRNA K15196 BRF1, GTF3B transcription factor IIIB 90 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15196 Q8CFK2 1199 6.0e-130 Transcription factor IIIB 90 kDa subunit OS=Mus musculus GN=Brf1 PE=2 SV=1 PF00382 Transcription factor TFIIB repeat -- -- GO:0017025 TBP-class protein binding -- -- KOG1598 Transcription initiation factor TFIIIB, Brf1 subunit Cluster-8309.30429 BF_2 33.40 0.80 2028 91088191 XP_972764.1 335 1.9e-28 PREDICTED: ribonuclease UK114 [Tribolium castaneum]>gi|270012137|gb|EFA08585.1| hypothetical protein TcasGA2_TC006240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52759 285 4.9e-24 Ribonuclease UK114 OS=Rattus norvegicus GN=Hrsp12 PE=1 SV=3 PF08675 RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0046872//GO:0003723//GO:0004535 metal ion binding//RNA binding//poly(A)-specific ribonuclease activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG2317 Putative translation initiation inhibitor UK114/IBM1 Cluster-8309.30430 BF_2 72.04 0.76 4238 642913457 XP_008201020.1 3244 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.3e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00784//PF00023 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.30431 BF_2 72.70 0.77 4222 91093345 XP_967700.1 926 1.2e-96 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X9 [Tribolium castaneum] 642938317 XM_962607.3 231 7.42474e-115 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 P81269 205 1.9e-14 Cyclic AMP-dependent transcription factor ATF-1 OS=Mus musculus GN=Atf1 PE=1 SV=1 PF03131//PF00170//PF07716//PF02173 bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper//pKID domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700//GO:0005515 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding//protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.30432 BF_2 1.00 0.67 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30433 BF_2 2684.16 12.33 9392 642937160 XP_969386.2 1135 1.5e-120 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] 242018355 XM_002429598.1 78 1.87077e-29 Pediculus humanus corporis Prolyl 4-hydroxylase alpha-1 subunit precursor, putative, mRNA K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 Q5RAG8 833 6.4e-87 Prolyl 4-hydroxylase subunit alpha-1 OS=Pongo abelii GN=P4HA1 PE=2 SV=1 PF08476//PF08336//PF13640//PF03171//PF00312 Viral D10 N-terminal//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//2OG-Fe(II) oxygenase superfamily//2OG-Fe(II) oxygenase superfamily//Ribosomal protein S15 GO:0006412//GO:0006560//GO:0006525//GO:0018401//GO:0055114//GO:0042254 translation//proline metabolic process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//oxidation-reduction process//ribosome biogenesis GO:0016702//GO:0016791//GO:0016491//GO:0004656//GO:0003735 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//phosphatase activity//oxidoreductase activity//procollagen-proline 4-dioxygenase activity//structural constituent of ribosome GO:0005783//GO:0005840//GO:0005622 endoplasmic reticulum//ribosome//intracellular KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.30434 BF_2 101.96 0.44 10023 642937160 XP_969386.2 1135 1.6e-120 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] 242018355 XM_002429598.1 78 1.99696e-29 Pediculus humanus corporis Prolyl 4-hydroxylase alpha-1 subunit precursor, putative, mRNA K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 P13674 833 6.9e-87 Prolyl 4-hydroxylase subunit alpha-1 OS=Homo sapiens GN=P4HA1 PE=1 SV=2 PF03171//PF08336//PF08476//PF13640 2OG-Fe(II) oxygenase superfamily//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Viral D10 N-terminal//2OG-Fe(II) oxygenase superfamily GO:0006560//GO:0006525//GO:0018401//GO:0055114 proline metabolic process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//oxidation-reduction process GO:0016702//GO:0016791//GO:0016491//GO:0004656 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//phosphatase activity//oxidoreductase activity//procollagen-proline 4-dioxygenase activity GO:0005783 endoplasmic reticulum KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.30437 BF_2 695.78 3.63 8306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05399//PF04805 Ectropic viral integration site 2A protein (EVI2A)//E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30438 BF_2 77.22 0.40 8291 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05399//PF04805 Ectropic viral integration site 2A protein (EVI2A)//E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30439 BF_2 89.00 2.26 1935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30441 BF_2 433.01 11.78 1825 801404410 XP_012061865.1 1863 1.1e-205 PREDICTED: 26S protease regulatory subunit 6B [Atta cephalotes] 194762611 XM_001963392.1 392 0 Drosophila ananassae GF20295 (Dana\GF20295), mRNA K03063 PSMC4, RPT3 26S proteasome regulatory subunit T3 http://www.genome.jp/dbget-bin/www_bget?ko:K03063 P46507 1847 3.3e-205 26S protease regulatory subunit 6B OS=Manduca sexta PE=2 SV=1 PF05496//PF06068//PF07724//PF00005//PF03266//PF07726//PF01637//PF00910//PF01695//PF07728//PF01057//PF00158//PF00004//PF02367//PF06414//PF00931 Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//AAA domain (Cdc48 subfamily)//ABC transporter//NTPase//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//NB-ARC domain GO:0019079//GO:0006281//GO:0006355//GO:0006310//GO:0002949 viral genome replication//DNA repair//regulation of transcription, DNA-templated//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0008134//GO:0016887//GO:0016301//GO:0003723//GO:0003678//GO:0043531//GO:0003724//GO:0009378 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//ATPase activity//kinase activity//RNA binding//DNA helicase activity//ADP binding//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0727 26S proteasome regulatory complex, ATPase RPT3 Cluster-8309.30447 BF_2 120.18 1.87 2978 270009865 EFA06313.1 2023 5.1e-224 hypothetical protein TcasGA2_TC009182 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REG1 838 5.4e-88 Squamous cell carcinoma antigen recognized by T-cells 3 OS=Pongo abelii GN=SART3 PE=2 SV=1 PF13174//PF16367//PF13414//PF00076//PF05843//PF08777 Tetratricopeptide repeat//RNA recognition motif//TPR repeat//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Suppressor of forked protein (Suf)//RNA binding motif GO:0006397 mRNA processing GO:0005515//GO:0003723//GO:0003676 protein binding//RNA binding//nucleic acid binding GO:0005634 nucleus KOG0128 RNA-binding protein SART3 (RRM superfamily) Cluster-8309.30451 BF_2 130.72 0.97 5914 91088827 XP_970265.1 2242 4.1e-249 PREDICTED: THO complex subunit 1 [Tribolium castaneum]>gi|270012332|gb|EFA08780.1| hypothetical protein TcasGA2_TC006470 [Tribolium castaneum] 805773091 XM_003701730.2 90 2.50946e-36 PREDICTED: Megachile rotundata THO complex subunit 1 (LOC100880227), mRNA K12878 THOC1 THO complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12878 Q96FV9 1053 1.2e-112 THO complex subunit 1 OS=Homo sapiens GN=THOC1 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2491 Nuclear matrix protein Cluster-8309.30452 BF_2 122.81 0.91 5932 91088827 XP_970265.1 2242 4.1e-249 PREDICTED: THO complex subunit 1 [Tribolium castaneum]>gi|270012332|gb|EFA08780.1| hypothetical protein TcasGA2_TC006470 [Tribolium castaneum] 805773091 XM_003701730.2 90 2.51714e-36 PREDICTED: Megachile rotundata THO complex subunit 1 (LOC100880227), mRNA K12878 THOC1 THO complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12878 Q96FV9 1053 1.3e-112 THO complex subunit 1 OS=Homo sapiens GN=THOC1 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2491 Nuclear matrix protein Cluster-8309.30454 BF_2 210.75 12.49 993 189234193 XP_970277.2 759 6.3e-78 PREDICTED: 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase [Tribolium castaneum]>gi|270002697|gb|EEZ99144.1| hypothetical protein TcasGA2_TC012925 [Tribolium castaneum] -- -- -- -- -- K08967 mtnD, mtnZ, ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K08967 E0W481 669 7.0e-69 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Pediculus humanus subsp. corporis GN=Phum_PHUM616140 PE=3 SV=1 PF00190//PF02311//PF03079 Cupin//AraC-like ligand binding domain//ARD/ARD' family GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0045735//GO:0010309 nutrient reservoir activity//acireductone dioxygenase [iron(II)-requiring] activity GO:0005634 nucleus KOG2107 Uncharacterized conserved protein, contains double-stranded beta-helix domain Cluster-8309.30455 BF_2 450.78 8.13 2607 91083569 XP_967824.1 831 7.4e-86 PREDICTED: transport and Golgi organization protein 11 [Tribolium castaneum]>gi|270007821|gb|EFA04269.1| hypothetical protein TcasGA2_TC014559 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q961C9 347 4.0e-31 Transport and Golgi organization protein 11 OS=Drosophila melanogaster GN=Tango11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30456 BF_2 28.06 0.37 3448 546678918 ERL89456.1 350 5.8e-30 hypothetical protein D910_06823 [Dendroctonus ponderosae] 462304277 APGK01049550.1 107 5.16549e-46 Dendroctonus ponderosae Seq01049560, whole genome shotgun sequence -- -- -- -- Q867Z4 288 3.7e-24 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00444//PF16622//PF01428//PF04926//PF02892//PF01155//PF00096 Zinc-finger double domain//Ribosomal protein L36//zinc-finger C2H2-type//AN1-like Zinc finger//Poly(A) polymerase predicted RNA binding domain//BED zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type GO:0042254//GO:0006412//GO:0006464//GO:0043631 ribosome biogenesis//translation//cellular protein modification process//RNA polyadenylation GO:0046872//GO:0003735//GO:0008270//GO:0016151//GO:0003723//GO:0003677 metal ion binding//structural constituent of ribosome//zinc ion binding//nickel cation binding//RNA binding//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.30458 BF_2 99.36 1.27 3561 642935103 XP_008197888.1 1698 3.0e-186 PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935105|ref|XP_008197889.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935107|ref|XP_008197890.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935109|ref|XP_008197891.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum]>gi|642935111|ref|XP_008197892.1| PREDICTED: uncharacterized protein LOC103314234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.30459 BF_2 149.13 4.72 1610 478250982 ENN71466.1 427 3.2e-39 hypothetical protein YQE_11883, partial [Dendroctonus ponderosae]>gi|546682648|gb|ERL92560.1| hypothetical protein D910_09873 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3046 BF_2 2.00 0.90 378 270002721 EEZ99168.1 148 1.7e-07 hypothetical protein TcasGA2_TC016167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30461 BF_2 612.76 6.05 4523 91079298 XP_966796.1 1790 8.1e-197 PREDICTED: putative sodium-coupled neutral amino acid transporter 10 [Tribolium castaneum]>gi|270004319|gb|EFA00767.1| hypothetical protein TcasGA2_TC003653 [Tribolium castaneum] -- -- -- -- -- K14996 SLC38A10 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14996 Q6PCF9 774 2.1e-80 Putative sodium-coupled neutral amino acid transporter 10 OS=Xenopus laevis GN=slc38a10 PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1305 Amino acid transporter protein Cluster-8309.30465 BF_2 124.93 5.19 1295 642925464 XP_008194565.1 397 7.8e-36 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.30468 BF_2 223.71 1.74 5666 642913872 XP_008201198.1 1400 1.7e-151 PREDICTED: SH3 domain-containing kinase-binding protein 1 isoform X2 [Tribolium castaneum] 23589286 AK116679.1 38 1.93865e-07 Ciona intestinalis cDNA, clone:cieg003e24, full insert sequence K12470 SH3KBP1, CIN85 SH3 domain-containing kinase-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12470 Q925Q9 306 5.0e-26 SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus GN=Sh3kbp1 PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG4348 Adaptor protein CMS/SETA Cluster-8309.30469 BF_2 83.65 0.65 5650 642913872 XP_008201198.1 1400 1.7e-151 PREDICTED: SH3 domain-containing kinase-binding protein 1 isoform X2 [Tribolium castaneum] 23589286 AK116679.1 38 1.93314e-07 Ciona intestinalis cDNA, clone:cieg003e24, full insert sequence K12470 SH3KBP1, CIN85 SH3 domain-containing kinase-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12470 Q925Q9 306 5.0e-26 SH3 domain-containing kinase-binding protein 1 OS=Rattus norvegicus GN=Sh3kbp1 PE=1 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4348 Adaptor protein CMS/SETA Cluster-8309.30471 BF_2 4.07 0.37 749 91087023 XP_974255.1 711 1.7e-72 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q9C0D9 423 1.8e-40 Ethanolaminephosphotransferase 1 OS=Homo sapiens GN=EPT1 PE=1 SV=3 PF01066//PF01545 CDP-alcohol phosphatidyltransferase//Cation efflux family GO:0006812//GO:0055085//GO:0008654 cation transport//transmembrane transport//phospholipid biosynthetic process GO:0016780//GO:0008324 phosphotransferase activity, for other substituted phosphate groups//cation transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.30472 BF_2 297.92 70.36 464 91080431 XP_968599.1 326 4.7e-28 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30473 BF_2 520.35 14.33 1806 91094379 XP_970941.1 1077 1.5e-114 PREDICTED: 39S ribosomal protein L4, mitochondrial [Tribolium castaneum]>gi|270014913|gb|EFA11361.1| hypothetical protein TcasGA2_TC011518 [Tribolium castaneum] -- -- -- -- -- K02926 RP-L4, MRPL4, rplD large subunit ribosomal protein L4 http://www.genome.jp/dbget-bin/www_bget?ko:K02926 Q32PI6 676 2.0e-69 39S ribosomal protein L4, mitochondrial OS=Bos taurus GN=MRPL4 PE=1 SV=1 PF00573//PF03497//PF01084 Ribosomal protein L4/L1 family//Anthrax toxin LF subunit//Ribosomal protein S18 GO:0042254//GO:0006171//GO:0006412//GO:0009405 ribosome biogenesis//cAMP biosynthetic process//translation//pathogenesis GO:0003735//GO:0008294 structural constituent of ribosome//calcium- and calmodulin-responsive adenylate cyclase activity GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1624 Mitochondrial/chloroplast ribosomal protein L4 Cluster-8309.30475 BF_2 28.05 0.50 2611 270007965 EFA04413.1 1862 2.1e-205 hypothetical protein TcasGA2_TC014713 [Tribolium castaneum] 642924630 XM_008196149.1 178 1.32587e-85 PREDICTED: Tribolium castaneum uncharacterized LOC663690 (LOC663690), transcript variant X3, mRNA K17494 CSRNP cysteine/serine-rich nuclear protein http://www.genome.jp/dbget-bin/www_bget?ko:K17494 Q8WYN3 588 4.6e-59 Cysteine/serine-rich nuclear protein 3 OS=Homo sapiens GN=CSRNP3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30478 BF_2 37.18 0.41 4089 91094941 XP_967472.1 2771 1.3e-310 PREDICTED: coatomer subunit alpha [Tribolium castaneum]>gi|270016760|gb|EFA13206.1| hypothetical protein TcasGA2_TC016033 [Tribolium castaneum] 817054142 XM_012410510.1 255 3.2744e-128 PREDICTED: Athalia rosae coatomer subunit alpha (LOC105691786), mRNA K05236 COPA coatomer protein complex, subunit alpha (xenin) http://www.genome.jp/dbget-bin/www_bget?ko:K05236 Q8CIE6 2469 5.5e-277 Coatomer subunit alpha OS=Mus musculus GN=Copa PE=1 SV=2 PF06957//PF00400//PF04053//PF13414 Coatomer (COPI) alpha subunit C-terminus//WD domain, G-beta repeat//Coatomer WD associated region//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG0292 Vesicle coat complex COPI, alpha subunit Cluster-8309.30479 BF_2 589.35 11.75 2386 270015207 EFA11655.1 939 2.0e-98 hypothetical protein TcasGA2_TC004080 [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 A6QNP3 340 2.4e-30 Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus GN=PPP1R3B PE=2 SV=1 PF16760//PF03370 Starch/carbohydrate-binding module (family 53)//Carbohydrate/starch-binding module (family 21) -- -- GO:0005515//GO:2001070 protein binding//starch binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.30480 BF_2 32.66 0.69 2275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30484 BF_2 88.65 3.22 1440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.30485 BF_2 2009.28 46.67 2088 478255296 ENN75522.1 1701 7.8e-187 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 1.4e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.30489 BF_2 42.57 1.49 1486 399108175 AFP20535.1 597 5.7e-59 splicing factor 3b subunit 1 [Rhyzopertha dominica] 642934611 XM_008199516.1 94 3.70311e-39 PREDICTED: Tribolium castaneum splicing factor 3B subunit 1 (LOC660131), transcript variant X2, mRNA K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O57683 368 8.4e-34 Splicing factor 3B subunit 1 OS=Xenopus laevis GN=sf3b1 PE=2 SV=1 PF04162 Gyrovirus capsid protein (VP1) -- -- -- -- GO:0019028 viral capsid KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.30492 BF_2 648.51 6.97 4181 478257956 ENN78094.1 1229 8.4e-132 hypothetical protein YQE_05248, partial [Dendroctonus ponderosae]>gi|546676500|gb|ERL87498.1| hypothetical protein D910_04890, partial [Dendroctonus ponderosae] -- -- -- -- -- K04640 GNA guanine nucleotide-binding protein subunit alpha, other http://www.genome.jp/dbget-bin/www_bget?ko:K04640 Q05337 799 2.5e-83 Guanine nucleotide-binding protein G(f) subunit alpha OS=Drosophila melanogaster GN=Galphaf PE=2 SV=1 PF00503//PF00025//PF04670//PF07992//PF08477 G-protein alpha subunit//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Pyridine nucleotide-disulphide oxidoreductase//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0007264//GO:0055114//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//oxidation-reduction process//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0031683//GO:0016491//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//G-protein beta/gamma-subunit complex binding//oxidoreductase activity//GTPase activity -- -- KOG0099 G protein subunit Galphas, small G protein superfamily Cluster-8309.30493 BF_2 1.00 1.63 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30495 BF_2 4.00 3.47 327 91078028 XP_970713.1 272 6.1e-22 PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914852|ref|XP_008195047.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914854|ref|XP_008195052.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|270002305|gb|EEZ98752.1| hypothetical protein TcasGA2_TC001316 [Tribolium castaneum] -- -- -- -- -- K17218 sqr sulfide:quinone oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K17218 Q9Y6N5 205 1.5e-15 Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1 PF03402 Vomeronasal organ pheromone receptor family, V1R GO:0007186//GO:0055114//GO:0007606//GO:0019236 G-protein coupled receptor signaling pathway//oxidation-reduction process//sensory perception of chemical stimulus//response to pheromone GO:0016503//GO:0016491 pheromone receptor activity//oxidoreductase activity GO:0016021 integral component of membrane KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein Cluster-8309.30497 BF_2 105.32 1.29 3702 478257956 ENN78094.1 665 1.9e-66 hypothetical protein YQE_05248, partial [Dendroctonus ponderosae]>gi|546676500|gb|ERL87498.1| hypothetical protein D910_04890, partial [Dendroctonus ponderosae] -- -- -- -- -- K17218 sqr sulfide:quinone oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K17218 Q9R112 486 4.4e-47 Sulfide:quinone oxidoreductase, mitochondrial OS=Mus musculus GN=Sqrdl PE=1 SV=3 PF10662//PF00025//PF00503//PF08477//PF07992 Ethanolamine utilisation - propanediol utilisation//ADP-ribosylation factor family//G-protein alpha subunit//Ras of Complex, Roc, domain of DAPkinase//Pyridine nucleotide-disulphide oxidoreductase GO:0007264//GO:0055114//GO:0007186//GO:0006576//GO:0007165 small GTPase mediated signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway//cellular biogenic amine metabolic process//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0016491//GO:0003924//GO:0005524//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//oxidoreductase activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding -- -- KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein Cluster-8309.30498 BF_2 334.00 12.73 1385 91078028 XP_970713.1 951 4.8e-100 PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914852|ref|XP_008195047.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|642914854|ref|XP_008195052.1| PREDICTED: sulfide:quinone oxidoreductase, mitochondrial [Tribolium castaneum]>gi|270002305|gb|EEZ98752.1| hypothetical protein TcasGA2_TC001316 [Tribolium castaneum] -- -- -- -- -- K17218 sqr sulfide:quinone oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K17218 Q9Y6N5 677 1.2e-69 Sulfide:quinone oxidoreductase, mitochondrial OS=Homo sapiens GN=SQRDL PE=1 SV=1 PF03402//PF01266//PF05834//PF07992//PF03521//PF03529//PF00070 Vomeronasal organ pheromone receptor family, V1R//FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Kv2 voltage-gated K+ channel//Otx1 transcription factor//Pyridine nucleotide-disulphide oxidoreductase GO:0006813//GO:0007275//GO:0019236//GO:0016117//GO:0007606//GO:0055114//GO:0007186 potassium ion transport//multicellular organismal development//response to pheromone//carotenoid biosynthetic process//sensory perception of chemical stimulus//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0016491//GO:0016705//GO:0016503//GO:0005249//GO:0003700 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//pheromone receptor activity//voltage-gated potassium channel activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016021//GO:0008076 transcription factor complex//nucleus//integral component of membrane//voltage-gated potassium channel complex KOG3851 Sulfide:quinone oxidoreductase/flavo-binding protein Cluster-8309.30499 BF_2 35.02 0.33 4769 91086719 XP_970742.1 874 1.4e-90 PREDICTED: guanine nucleotide-binding protein G(f) subunit alpha [Tribolium castaneum] -- -- -- -- -- K04640 GNA guanine nucleotide-binding protein subunit alpha, other http://www.genome.jp/dbget-bin/www_bget?ko:K04640 Q05337 596 9.9e-60 Guanine nucleotide-binding protein G(f) subunit alpha OS=Drosophila melanogaster GN=Galphaf PE=2 SV=1 PF07992//PF08477//PF00503//PF00025 Pyridine nucleotide-disulphide oxidoreductase//Ras of Complex, Roc, domain of DAPkinase//G-protein alpha subunit//ADP-ribosylation factor family GO:0007264//GO:0055114//GO:0007186//GO:0007165 small GTPase mediated signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0019001//GO:0004871//GO:0016491//GO:0003924//GO:0031683 GTP binding//guanyl nucleotide binding//signal transducer activity//oxidoreductase activity//GTPase activity//G-protein beta/gamma-subunit complex binding -- -- KOG0099 G protein subunit Galphas, small G protein superfamily Cluster-8309.30502 BF_2 10.39 0.66 948 158562470 ABW74141.1 463 1.3e-43 cuticular protein Ld-CP1v2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30503 BF_2 191.61 32.99 530 158562470 ABW74141.1 451 1.7e-42 cuticular protein Ld-CP1v2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q8T635 124 5.9e-06 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30505 BF_2 1923.00 33.17 2712 332373700 AEE61991.1 1453 5.8e-158 unknown [Dendroctonus ponderosae]>gi|478250001|gb|ENN70507.1| hypothetical protein YQE_12683, partial [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 732 9.5e-76 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF01053//PF01212//PF00155 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG1368 Threonine aldolase Cluster-8309.30507 BF_2 263.95 3.10 3846 642925796 XP_008190317.1 3356 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1706 1.5e-188 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.30509 BF_2 375.71 23.39 959 642936307 XP_008198389.1 517 7.0e-50 PREDICTED: protein FAM107B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI00 145 3.9e-08 Protein FAM107B OS=Bos taurus GN=FAM107B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30511 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- A2VDP4 123 5.7e-06 Zinc finger protein 567 OS=Bos taurus GN=ZNF567 PE=2 SV=1 PF16622//PF13912//PF00130//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0035556 intracellular signal transduction GO:0046872 metal ion binding -- -- -- -- Cluster-8309.30512 BF_2 39.89 0.65 2836 91091236 XP_967765.1 504 6.7e-48 PREDICTED: golgin subfamily A member 7 [Tribolium castaneum]>gi|642936471|ref|XP_008198449.1| PREDICTED: golgin subfamily A member 7 [Tribolium castaneum]>gi|270014108|gb|EFA10556.1| hypothetical protein TcasGA2_TC012812 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2TAP0 291 1.4e-24 Golgin subfamily A member 7B OS=Homo sapiens GN=GOLGA7B PE=2 SV=2 PF03650 Uncharacterised protein family (UPF0041) GO:0006850 mitochondrial pyruvate transport -- -- GO:0005743 mitochondrial inner membrane KOG4069 Uncharacterized conserved protein Cluster-8309.30513 BF_2 147.75 2.24 3042 86515428 NP_001034540.1 994 1.1e-104 protein decapentaplegic precursor [Tribolium castaneum]>gi|642921157|ref|XP_008192737.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921159|ref|XP_008192738.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921161|ref|XP_008192739.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|2501171|sp|Q26974.1|DECA_TRICA RecName: Full=Protein decapentaplegic; Flags: Precursor>gi|1458196|gb|AAB38392.1| decapentaplegic protein [Tribolium castaneum]>gi|270006465|gb|EFA02913.1| decapentaplegic [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 Q26974 994 4.5e-106 Protein decapentaplegic OS=Tribolium castaneum GN=dpp PE=3 SV=1 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.30514 BF_2 112.66 1.76 2965 91081321 XP_969973.1 585 2.8e-57 PREDICTED: CD2 antigen cytoplasmic tail-binding protein 2 homolog [Tribolium castaneum]>gi|270005202|gb|EFA01650.1| hypothetical protein TcasGA2_TC007221 [Tribolium castaneum] -- -- -- -- -- K13099 CD2BP2, PPP1R59 CD2 antigen cytoplasmic tail-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13099 Q9VKV5 482 1.0e-46 CD2 antigen cytoplasmic tail-binding protein 2 homolog OS=Drosophila melanogaster GN=holn1 PE=1 SV=1 PF02213 GYF domain -- -- GO:0005515 protein binding -- -- KOG2950 Uncharacterized protein involved in protein-protein interaction, contains polyproline-binding GYF domain Cluster-8309.30515 BF_2 432.88 11.10 1918 91078380 XP_974219.1 322 5.7e-27 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q7ZVG6 204 1.1e-14 E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1 PE=2 SV=2 PF03145 Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.30519 BF_2 3.02 0.34 658 189234413 XP_975276.2 271 1.6e-21 PREDICTED: uncharacterized protein LOC664170 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30522 BF_2 381.79 10.43 1819 649572303 NP_001280516.1 2217 9.9e-247 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 649572302 NM_001293587.1 425 0 Tribolium castaneum V-type proton ATPase subunit H (VhaSFD), mRNA >gnl|BL_ORD_ID|19160614 Tribolium castaneum strain Georgia-1 V-type proton ATPase subunit H variant-2 (VhaSFD) mRNA, complete cds, alternatively spliced K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1591 1.6e-175 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF11698//PF00514//PF01602//PF02985 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//HEAT repeat GO:0015992//GO:0006119//GO:0015991//GO:0006886//GO:0016192 proton transport//oxidative phosphorylation//ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle-mediated transport GO:0046961//GO:0016820//GO:0005515 proton-transporting ATPase activity, rotational mechanism//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.30523 BF_2 784.71 27.02 1502 91092262 XP_967283.1 1903 2.1e-210 PREDICTED: methionine aminopeptidase 1 [Tribolium castaneum]>gi|270001228|gb|EEZ97675.1| hypothetical protein TcasGA2_TC016220 [Tribolium castaneum] 746858202 XM_011061556.1 236 4.32478e-118 PREDICTED: Acromyrmex echinatior methionine aminopeptidase 1 (LOC105149265), transcript variant X2, mRNA K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q4QRK0 1429 8.0e-157 Methionine aminopeptidase 1 OS=Danio rerio GN=metap1 PE=2 SV=2 -- -- GO:0009987//GO:0006508 cellular process//proteolysis GO:0046872//GO:0004177//GO:0008270//GO:0008235 metal ion binding//aminopeptidase activity//zinc ion binding//metalloexopeptidase activity -- -- KOG2738 Putative methionine aminopeptidase Cluster-8309.30524 BF_2 87.63 0.60 6372 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.3e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF00023//PF13606//PF09266//PF01331//PF01279 Ankyrin repeat//Ankyrin repeat//Viral DNA topoisomerase I, N-terminal//mRNA capping enzyme, catalytic domain//Parathyroid hormone family GO:0006265//GO:0006370//GO:0007165//GO:0006397 DNA topological change//7-methylguanosine mRNA capping//signal transduction//mRNA processing GO:0005179//GO:0003916//GO:0004484//GO:0005515//GO:0003677 hormone activity//DNA topoisomerase activity//mRNA guanylyltransferase activity//protein binding//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.30527 BF_2 5.00 0.31 966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30529 BF_2 100.74 12.55 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30530 BF_2 17.89 0.34 2507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30531 BF_2 20.38 1.03 1112 642939241 XP_008194774.1 1159 2.9e-124 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q4JM44 411 6.5e-39 Phosphatidylcholine:ceramide cholinephosphotransferase 2 OS=Rattus norvegicus GN=Sgms2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.30533 BF_2 239.31 1.71 6153 91090886 XP_973247.1 4721 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X1 [Tribolium castaneum]>gi|270013232|gb|EFA09680.1| hypothetical protein TcasGA2_TC011808 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 2203 5.8e-246 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006464 protein ubiquitination//cellular protein modification process GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.30534 BF_2 23.05 0.45 2434 642919790 XP_008192068.1 687 3.4e-69 PREDICTED: uncharacterized protein LOC661416 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12162 UFM1 ubiquitin-fold modifier 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12162 Q7PXE2 319 6.7e-28 Ubiquitin-fold modifier 1 OS=Anopheles gambiae GN=AGAP001364 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3483 Uncharacterized conserved protein Cluster-8309.30536 BF_2 1.00 0.36 402 3915093 Q94571.1 451 1.3e-42 RecName: Full=Tubulin beta-2 chain; AltName: Full=Beta-II tubulin [Homarus americanus]>gi|1519336|gb|AAB07482.1| beta-II tubulin [Homarus americanus] 836713074 XM_012935056.1 80 5.71156e-32 PREDICTED: Sorex araneus tubulin, beta 2B class IIb (TUBB2B), transcript variant X2, mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q94571 451 5.4e-44 Tubulin beta-2 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- -- -- Cluster-8309.30537 BF_2 16.71 1.03 963 3915087 Q25009.1 1516 1.0e-165 RecName: Full=Tubulin beta-1 chain; AltName: Full=Beta-I tubulin [Homarus americanus]>gi|1272242|gb|AAC47306.1| beta-I tubulin [Homarus americanus] 1272241 U41811.1 454 0 HAU41811 Homarus americanus beta-I tubulin mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q25009 1516 4.2e-167 Tubulin beta-1 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- -- -- Cluster-8309.30539 BF_2 265.00 12.88 1148 642927632 XP_008195342.1 379 8.4e-34 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q6NT99 230 6.6e-18 Dual specificity protein phosphatase 23 OS=Mus musculus GN=Dusp23 PE=2 SV=1 PF00782//PF00102//PF05706 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004721//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1720 Protein tyrosine phosphatase CDC14 Cluster-8309.30542 BF_2 261.00 2.88 4077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30544 BF_2 272.00 15.59 1017 91079114 XP_975377.1 393 1.8e-35 PREDICTED: protein lethal(2)essential for life [Tribolium castaneum]>gi|270004217|gb|EFA00665.1| hypothetical protein TcasGA2_TC003541 [Tribolium castaneum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P02517 226 1.7e-17 Heat shock protein 26 OS=Drosophila melanogaster GN=Hsp26 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.30545 BF_2 663.96 11.57 2687 642914966 XP_008190462.1 1488 5.0e-162 PREDICTED: putative ATPase N2B [Tribolium castaneum]>gi|270002336|gb|EEZ98783.1| hypothetical protein TcasGA2_TC001347 [Tribolium castaneum] 807020276 XM_004520531.2 44 4.21715e-11 PREDICTED: Ceratitis capitata putative ATPase N2B (LOC101449143), mRNA K18798 AFG1, LACE1 protein AFG1 http://www.genome.jp/dbget-bin/www_bget?ko:K18798 P46441 1116 2.8e-120 Putative ATPase N2B OS=Haematobia irritans PE=2 SV=1 PF03969//PF00004//PF00400 AFG1-like ATPase//ATPase family associated with various cellular activities (AAA)//WD domain, G-beta repeat -- -- GO:0005524//GO:0005515 ATP binding//protein binding -- -- KOG0271 Notchless-like WD40 repeat-containing protein Cluster-8309.30546 BF_2 87.00 4.52 1092 801383453 XP_012054888.1 296 3.4e-24 PREDICTED: tubulin alpha-1 chain-like [Atta cephalotes] 837820915 XM_012928918.1 142 5.60361e-66 PREDICTED: Ochotona princeps tubulin alpha chain, testis-specific-like (LOC101519453), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q68FR8 296 1.4e-25 Tubulin alpha-3 chain OS=Rattus norvegicus GN=Tuba3a PE=2 SV=1 PF13545 Crp-like helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG1376 Alpha tubulin Cluster-8309.30547 BF_2 1028.62 53.00 1099 478252683 ENN73079.1 193 3.0e-12 hypothetical protein YQE_10283, partial [Dendroctonus ponderosae]>gi|546682842|gb|ERL92731.1| hypothetical protein D910_10041 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30548 BF_2 7.00 0.97 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30549 BF_2 260.73 5.09 2429 478257813 ENN77956.1 1797 6.7e-198 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 1.3e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30550 BF_2 7.38 0.53 874 91094895 XP_973250.1 718 3.1e-73 PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923028|ref|XP_008200501.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923030|ref|XP_008200502.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- H3BPM6 258 2.8e-21 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.30552 BF_2 656.06 2.84 9945 642926098 XP_008194783.1 5687 0.0e+00 PREDICTED: uncharacterized protein KIAA1109 [Tribolium castaneum] 755951836 XM_011303587.1 50 7.2791e-14 PREDICTED: Fopius arisanus uncharacterized protein KIAA1109 (LOC105265834), transcript variant X9, mRNA -- -- -- -- A2AAE1 1928 7.2e-214 Uncharacterized protein KIAA1109 OS=Mus musculus GN=Kiaa1109 PE=1 SV=4 PF08093 Magi 5 toxic peptide family GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG3596 Uncharacterized conserved protein Cluster-8309.30553 BF_2 13.00 0.51 1348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30554 BF_2 10.00 54.79 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30556 BF_2 437.25 22.50 1100 478260763 ENN80436.1 851 1.5e-88 hypothetical protein YQE_03140, partial [Dendroctonus ponderosae]>gi|546683758|gb|ERL93523.1| hypothetical protein D910_10812 [Dendroctonus ponderosae] 685042175 LN590700.1 37 1.32105e-07 Cyprinus carpio genome assembly common carp genome ,scaffold LG10 K12165 UFC1 ufm1-conjugating enzyme 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12165 Q178A5 815 9.2e-86 Ubiquitin-fold modifier-conjugating enzyme 1 OS=Aedes aegypti GN=AAEL005968 PE=3 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG3357 Uncharacterized conserved protein Cluster-8309.30558 BF_2 38.02 0.93 1998 642923366 XP_973695.2 1695 3.7e-186 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.30559 BF_2 516.47 11.10 2234 642918250 XP_008191430.1 2398 1.3e-267 PREDICTED: CCR4-NOT transcription complex subunit 3 [Tribolium castaneum] 780625043 XM_011709899.1 203 1.43337e-99 PREDICTED: Wasmannia auropunctata CCR4-NOT transcription complex subunit 3 (LOC105462953), mRNA K12580 CNOT3, NOT3 CCR4-NOT transcription complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12580 O75175 858 1.9e-90 CCR4-NOT transcription complex subunit 3 OS=Homo sapiens GN=CNOT3 PE=1 SV=1 PF04153//PF07352//PF04065 NOT2 / NOT3 / NOT5 family//Bacteriophage Mu Gam like protein//Not1 N-terminal domain, CCR4-Not complex component GO:0006355//GO:0042262 regulation of transcription, DNA-templated//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG2150 CCR4-NOT transcriptional regulation complex, NOT5 subunit Cluster-8309.30560 BF_2 364.88 5.68 2974 478256729 ENN76910.1 1408 1.0e-152 hypothetical protein YQE_06557, partial [Dendroctonus ponderosae]>gi|546672603|gb|ERL84404.1| hypothetical protein D910_01837 [Dendroctonus ponderosae] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 436 2.2e-41 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF04848//PF00083 Major Facilitator Superfamily//Poxvirus A22 protein//Sugar (and other) transporter GO:0006310//GO:0006281//GO:0055085 DNA recombination//DNA repair//transmembrane transport GO:0000287//GO:0016788//GO:0000400//GO:0022857 magnesium ion binding//hydrolase activity, acting on ester bonds//four-way junction DNA binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.30562 BF_2 691.92 8.09 3866 91077466 XP_968191.1 636 4.5e-63 PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|642914015|ref|XP_008201511.1| PREDICTED: uncharacterized protein LOC656577 [Tribolium castaneum]>gi|270002138|gb|EEZ98585.1| hypothetical protein TcasGA2_TC001099 [Tribolium castaneum] -- -- -- -- -- K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 Q5EB97 167 4.5e-10 Zinc finger CCHC domain-containing protein 10 OS=Rattus norvegicus GN=Zcchc10 PE=2 SV=2 PF04889//PF09726//PF00098//PF02190 Cwf15/Cwc15 cell cycle control protein//Transmembrane protein//Zinc knuckle//ATP-dependent protease La (LON) substrate-binding domain GO:0006508//GO:0006510//GO:0000398 proteolysis//obsolete ATP-dependent proteolysis//mRNA splicing, via spliceosome GO:0008270//GO:0004176//GO:0003676 zinc ion binding//ATP-dependent peptidase activity//nucleic acid binding GO:0016021//GO:0005681 integral component of membrane//spliceosomal complex KOG3116 Predicted C3H1-type Zn-finger protein Cluster-8309.30564 BF_2 247.89 3.33 3401 91094595 XP_970633.1 1466 2.2e-159 PREDICTED: cytochrome P450 6k1 [Tribolium castaneum]>gi|270016411|gb|EFA12857.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 966 8.8e-103 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0046872//GO:0016705 heme binding//iron ion binding//oxidoreductase activity//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30565 BF_2 1489.53 44.64 1683 91085589 XP_968685.1 1955 2.2e-216 PREDICTED: selenide, water dikinase [Tribolium castaneum]>gi|270010074|gb|EFA06522.1| hypothetical protein TcasGA2_TC009425 [Tribolium castaneum] -- -- -- -- -- K01008 selD, SEPHS selenide, water dikinase http://www.genome.jp/dbget-bin/www_bget?ko:K01008 O18373 1747 1.2e-193 Selenide, water dikinase OS=Drosophila melanogaster GN=SelD PE=2 SV=1 -- -- GO:0008152 metabolic process GO:0005524//GO:0004756 ATP binding//selenide, water dikinase activity -- -- KOG3939 Selenophosphate synthetase Cluster-8309.30566 BF_2 1779.22 24.24 3358 91085219 XP_972532.1 2370 3.3e-264 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009084|gb|EFA05532.1| hypothetical protein TcasGA2_TC015719 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 1008 1.2e-107 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05834//PF07992//PF00732//PF01266//PF05199//PF02254 Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0006813//GO:0006066//GO:0006563//GO:0055114//GO:0006544//GO:0006566//GO:0016117 potassium ion transport//alcohol metabolic process//L-serine metabolic process//oxidation-reduction process//glycine metabolic process//threonine metabolic process//carotenoid biosynthetic process GO:0016491//GO:0016614//GO:0016705//GO:0050660//GO:0008812 oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding//choline dehydrogenase activity -- -- -- -- Cluster-8309.30567 BF_2 16.16 0.38 2062 478270254 ENN83480.1 344 1.7e-29 hypothetical protein YQE_00162, partial [Dendroctonus ponderosae] -- -- -- -- -- K08370 CYBRD1 cytochrome b reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08370 Q6DDR3 159 2.0e-09 Cytochrome b reductase 1 OS=Xenopus laevis GN=cybrd1 PE=2 SV=2 PF00033//PF03188 Cytochrome b/b6/petB//Eukaryotic cytochrome b561 GO:0022904 respiratory electron transport chain -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.30568 BF_2 29.96 3.92 607 332375664 AEE62973.1 154 5.5e-08 unknown [Dendroctonus ponderosae]>gi|478254613|gb|ENN74856.1| hypothetical protein YQE_08626, partial [Dendroctonus ponderosae]>gi|546673364|gb|ERL84987.1| hypothetical protein D910_02410 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30570 BF_2 74.00 18.97 450 741829858 AJA91073.1 280 9.9e-23 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 243 7.9e-20 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30571 BF_2 15.90 1.30 797 91091114 XP_966512.1 704 1.2e-71 PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|91091116|ref|XP_975893.1| PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|270014090|gb|EFA10538.1| hypothetical protein TcasGA2_TC012793 [Tribolium castaneum] 768428971 XM_011557345.1 151 4.01268e-71 PREDICTED: Plutella xylostella GTP-binding nuclear protein Ran (LOC105386728), mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q9VZ23 681 2.3e-70 GTP-binding nuclear protein Ran OS=Drosophila melanogaster GN=ran PE=1 SV=1 PF01926//PF08477//PF00025//PF02367//PF00071//PF00910//PF04670//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Ras family//RNA helicase//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0002949//GO:0007186//GO:0006184//GO:0007264//GO:0007165//GO:0006913//GO:0006886 tRNA threonylcarbamoyladenosine modification//G-protein coupled receptor signaling pathway//obsolete GTP catabolic process//small GTPase mediated signal transduction//signal transduction//nucleocytoplasmic transport//intracellular protein transport GO:0005525//GO:0004871//GO:0019001//GO:0003724//GO:0003723//GO:0031683//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//RNA helicase activity//RNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0005622 intracellular KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-8309.30572 BF_2 510.00 99.70 501 91091114 XP_966512.1 340 1.2e-29 PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|91091116|ref|XP_975893.1| PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|270014090|gb|EFA10538.1| hypothetical protein TcasGA2_TC012793 [Tribolium castaneum] 645014666 XM_008205354.1 95 3.32292e-40 PREDICTED: Nasonia vitripennis GTP-binding nuclear protein Ran (LOC100114116), transcript variant X4, mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q9VZ23 295 8.3e-26 GTP-binding nuclear protein Ran OS=Drosophila melanogaster GN=ran PE=1 SV=1 -- -- GO:0006184//GO:0006913//GO:0006886//GO:0007264 obsolete GTP catabolic process//nucleocytoplasmic transport//intracellular protein transport//small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005622 intracellular KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-8309.30573 BF_2 665.68 10.41 2961 189234074 XP_970690.2 1301 2.7e-140 PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum]>gi|642912025|ref|XP_008199064.1| PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01785 galM, GALM aldose 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01785 Q66HG4 743 5.5e-77 Aldose 1-epimerase OS=Rattus norvegicus GN=Galm PE=1 SV=1 PF01263//PF05365 Aldose 1-epimerase//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0005975//GO:0006122 carbohydrate metabolic process//mitochondrial electron transport, ubiquinol to cytochrome c GO:0016853 isomerase activity GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane KOG1604 Predicted mutarotase Cluster-8309.30574 BF_2 447.03 13.42 1681 91081119 XP_975527.1 1499 1.7e-163 PREDICTED: lipoyl synthase, mitochondrial [Tribolium castaneum]>gi|270006027|gb|EFA02475.1| hypothetical protein TcasGA2_TC008166 [Tribolium castaneum] 675228061 LK023128.1 51 3.36432e-15 Plasmodium berghei ANKA genome assembly PBANKA01, chromosome : 13 K03644 lipA lipoic acid synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K03644 B4KYY0 1406 4.1e-154 Lipoyl synthase, mitochondrial OS=Drosophila mojavensis GN=Las PE=3 SV=1 PF04055 Radical SAM superfamily GO:0009107//GO:0009249 lipoate biosynthetic process//protein lipoylation GO:0003824//GO:0051536//GO:0016992//GO:0051539//GO:0046872 catalytic activity//iron-sulfur cluster binding//lipoate synthase activity//4 iron, 4 sulfur cluster binding//metal ion binding GO:0005739 mitochondrion KOG2672 Lipoate synthase Cluster-8309.30575 BF_2 16.97 0.49 1733 270014888 EFA11336.1 180 1.5e-10 hypothetical protein TcasGA2_TC010876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30576 BF_2 326.00 3.57 4112 641732547 XP_008156641.1 410 7.7e-37 PREDICTED: zinc finger protein 226-like [Eptesicus fuscus] -- -- -- -- -- K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q6ZR52 402 2.7e-37 Zinc finger protein 493 OS=Homo sapiens GN=ZNF493 PE=2 SV=3 PF01428//PF13912//PF10588//PF07975//PF00096//PF13465 AN1-like Zinc finger//C2H2-type zinc finger//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281//GO:0055114 DNA repair//oxidation-reduction process GO:0008270//GO:0016491//GO:0046872 zinc ion binding//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.30577 BF_2 486.48 11.92 1995 91076406 XP_969383.1 1230 3.1e-132 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 768 4.7e-80 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.30578 BF_2 641.52 11.83 2555 91076406 XP_969383.1 1230 3.9e-132 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 768 6.0e-80 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.30582 BF_2 56.60 0.76 3405 642920934 XP_001814127.2 1388 2.5e-150 PREDICTED: yemanuclein-alpha isoform X2 [Tribolium castaneum] -- -- -- -- -- K17492 UBN ubinuclein http://www.genome.jp/dbget-bin/www_bget?ko:K17492 Q80WC1 453 2.7e-43 Ubinuclein-2 OS=Mus musculus GN=Ubn2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30589 BF_2 36.25 1.23 1520 189234116 XP_968417.2 1175 5.6e-126 PREDICTED: uridine phosphorylase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 627 8.0e-64 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3728 Uridine phosphorylase Cluster-8309.30591 BF_2 346.68 16.21 1182 332372492 AEE61388.1 524 1.3e-50 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D8X2 376 7.9e-35 Coiled-coil domain-containing protein 124 OS=Mus musculus GN=Ccdc124 PE=2 SV=1 PF03552 Cellulose synthase GO:0030244//GO:0005985//GO:0005982//GO:0006011 cellulose biosynthetic process//sucrose metabolic process//starch metabolic process//UDP-glucose metabolic process GO:0016760 cellulose synthase (UDP-forming) activity GO:0016020 membrane KOG3223 Uncharacterized conserved protein Cluster-8309.30592 BF_2 308.70 3.75 3728 642929673 XP_008195930.1 1810 3.2e-199 PREDICTED: DNA methyltransferase 1-associated protein 1 [Tribolium castaneum] -- -- -- -- -- K11324 DMAP1, SWC4, EAF2 DNA methyltransferase 1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11324 Q9JI44 1178 2.5e-127 DNA methyltransferase 1-associated protein 1 OS=Mus musculus GN=Dmap1 PE=1 SV=1 PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2656 DNA methyltransferase 1-associated protein-1 Cluster-8309.30593 BF_2 247.00 6.26 1939 642931132 XP_008201675.1 792 1.8e-81 PREDICTED: uncharacterized protein DDB_G0286299-like [Tribolium castaneum]>gi|270011877|gb|EFA08325.1| hypothetical protein TcasGA2_TC005967 [Tribolium castaneum] -- -- -- -- -- K17578 ZCCHC9 zinc finger CCHC domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K17578 Q8N567 323 1.8e-28 Zinc finger CCHC domain-containing protein 9 OS=Homo sapiens GN=ZCCHC9 PE=2 SV=2 PF00098 Zinc knuckle -- -- GO:0003676//GO:0005488//GO:0008270 nucleic acid binding//binding//zinc ion binding -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.30595 BF_2 380.32 24.18 945 91095123 XP_970890.1 871 6.1e-91 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 646 3.1e-66 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106//PF01073//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008210//GO:0008152 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0000166//GO:0016491//GO:0016616//GO:0003824//GO:0050662//GO:0003854 nucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.30596 BF_2 12.68 0.61 1159 91095123 XP_970890.1 826 1.2e-85 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 601 6.3e-61 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01073//PF01370//PF12242 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008152//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//metabolic process//estrogen metabolic process GO:0000166//GO:0016616//GO:0016491//GO:0003824//GO:0050662//GO:0003854 nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.30598 BF_2 1562.85 8.19 8270 546680590 ERL90833.1 6072 0.0e+00 hypothetical protein D910_08178 [Dendroctonus ponderosae] 642925848 XM_008192328.1 61 4.64283e-20 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- Q6DFF9 2133 1.0e-237 Mitogen-activated protein kinase-binding protein 1 OS=Xenopus laevis GN=mapkbp1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1408 WD40 repeat protein Cluster-8309.30601 BF_2 1.00 1.13 312 91083531 XP_973193.1 391 9.3e-36 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q28960 152 2.0e-09 Carbonyl reductase [NADPH] 1 OS=Sus scrofa GN=CBR1 PE=1 SV=3 PF00106 short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.30603 BF_2 139.44 2.99 2238 478255296 ENN75522.1 1701 8.3e-187 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 1.5e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.30604 BF_2 65.97 1.05 2914 478255296 ENN75522.1 1701 1.1e-186 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 1.9e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.30605 BF_2 92.00 8.33 749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30607 BF_2 58.00 2.34 1326 91076178 XP_971722.1 1024 1.6e-108 PREDICTED: uncharacterized protein LOC660398 [Tribolium castaneum]>gi|270014727|gb|EFA11175.1| hypothetical protein TcasGA2_TC004782 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- -- -- Cluster-8309.30608 BF_2 6.00 0.84 587 270015462 EFA11910.1 268 3.2e-21 hypothetical protein TcasGA2_TC004067 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060 Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.30609 BF_2 391.15 10.44 1854 91084337 XP_972793.1 863 1.0e-89 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 3.43956e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 559 7.5e-56 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- -- -- GO:0005515 protein binding -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.30610 BF_2 16.80 0.87 1097 642926860 XP_971810.2 259 6.6e-20 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20662 157 1.8e-09 Zinc finger Y-chromosomal protein 2 OS=Mus musculus GN=Zfy2 PE=2 SV=2 PF02150//PF13465//PF00096 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//metal ion binding GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.30615 BF_2 103.05 1.32 3558 642932799 XP_008196988.1 3582 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X2 [Tribolium castaneum]>gi|270012453|gb|EFA08901.1| hypothetical protein TcasGA2_TC006604 [Tribolium castaneum] 642932798 XM_008198766.1 304 1.64133e-155 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1786 7.6e-198 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF13639//PF00637//PF14634//PF17123//PF17122//PF00097 Ring finger domain//Region in Clathrin and VPS//zinc-RING finger domain//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger) GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005622 intracellular KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.30616 BF_2 570.30 3.35 7403 642914685 XP_008190314.1 6201 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.1714e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08941 2043 2.5e-227 Proto-oncogene tyrosine-protein kinase ROS OS=Gallus gallus GN=ROS1 PE=1 SV=3 PF16656//PF00041//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0019497//GO:0006771 protein phosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0005524//GO:0046872//GO:0004672//GO:0003993 protein binding//ATP binding//metal ion binding//protein kinase activity//acid phosphatase activity -- -- -- -- Cluster-8309.30617 BF_2 570.23 17.25 1670 189237651 XP_001813448.1 675 5.8e-68 PREDICTED: N-acetylneuraminate lyase-like [Tribolium castaneum] -- -- -- -- -- K01639 E4.1.3.3, nanA, NPL N-acetylneuraminate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01639 Q5RDY1 336 4.9e-30 N-acetylneuraminate lyase OS=Pongo abelii GN=NPL PE=2 SV=1 PF00959//PF00701 Phage lysozyme//Dihydrodipicolinate synthetase family GO:0016998//GO:0009253//GO:0005975//GO:0008152 cell wall macromolecule catabolic process//peptidoglycan catabolic process//carbohydrate metabolic process//metabolic process GO:0003796//GO:0016829 lysozyme activity//lyase activity -- -- -- -- Cluster-8309.30618 BF_2 28.00 9.17 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30619 BF_2 35.00 8.97 450 478256535 ENN76719.1 477 1.4e-45 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NK53 223 1.7e-17 Zinc finger protein 233 OS=Homo sapiens GN=ZNF233 PE=2 SV=3 PF13895//PF13465//PF00096//PF06397//PF00628//PF04810 Immunoglobulin domain//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain//PHD-finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0005506//GO:0005515//GO:0008270 metal ion binding//iron ion binding//protein binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.30620 BF_2 264.56 1.27 8987 642911702 XP_008200708.1 4760 0.0e+00 PREDICTED: histone-lysine N-methyltransferase trithorax [Tribolium castaneum] -- -- -- -- -- K09186 MLL1 histone-lysine N-methyltransferase MLL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09186 Q24742 1546 1.3e-169 Histone-lysine N-methyltransferase trithorax OS=Drosophila virilis GN=trx PE=3 SV=1 PF05001//PF00856//PF06221//PF00628//PF16866//PF05964//PF05965//PF00439 RNA polymerase Rpb1 C-terminal repeat//SET domain//Putative zinc finger motif, C2HC5-type//PHD-finger//PHD-finger//F/Y-rich N-terminus//F/Y rich C-terminus//Bromodomain GO:0006366//GO:0006355 transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0008270 protein binding//DNA binding//zinc ion binding GO:0005665//GO:0005634 DNA-directed RNA polymerase II, core complex//nucleus KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.30622 BF_2 32.72 0.93 1765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01701//PF01578//PF13520//PF12199 Photosystem I reaction centre subunit IX / PsaJ//Cytochrome C assembly protein//Amino acid permease//Extracellular fibrinogen binding protein C terminal GO:0017004//GO:0003333//GO:0006865//GO:0015979 cytochrome complex assembly//amino acid transmembrane transport//amino acid transport//photosynthesis GO:0020037//GO:0001848//GO:0015171 heme binding//complement binding//amino acid transmembrane transporter activity GO:0005615//GO:0016020//GO:0009522 extracellular space//membrane//photosystem I -- -- Cluster-8309.30623 BF_2 494.00 7.37 3090 328719107 XP_003246665.1 255 5.4e-19 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 462318967 APGK01044227.1 110 9.93758e-48 Dendroctonus ponderosae Seq01044237, whole genome shotgun sequence K15605 KLF3 krueppel-like factor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15605 P15620 221 2.0e-16 Zinc finger protein 271 OS=Mus musculus GN=Znf271 PE=2 SV=1 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.30626 BF_2 504.53 16.75 1547 189234028 XP_973216.2 1787 6.1e-197 PREDICTED: dual specificity mitogen-activated protein kinase kinase dSOR1 [Tribolium castaneum]>gi|270014747|gb|EFA11195.1| hypothetical protein TcasGA2_TC004803 [Tribolium castaneum] -- -- -- -- -- K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q24324 1479 1.3e-162 Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster GN=Dsor1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-8309.30629 BF_2 15.64 0.36 2129 751799211 XP_011209556.1 692 7.9e-70 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 5.3e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF06839//PF00076//PF16367//PF00023//PF13606//PF00887 GRF zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Ankyrin repeat//Ankyrin repeat//Acyl CoA binding protein -- -- GO:0005515//GO:0008270//GO:0000062//GO:0003676 protein binding//zinc ion binding//fatty-acyl-CoA binding//nucleic acid binding -- -- -- -- Cluster-8309.30630 BF_2 2.00 0.69 407 642917800 XP_008191291.1 276 2.6e-22 PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|642917802|ref|XP_008191292.1| PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|270004486|gb|EFA00934.1| hypothetical protein TcasGA2_TC003840 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0PGJ6 151 3.4e-09 Aldo-keto reductase family 4 member C9 OS=Arabidopsis thaliana GN=AKR4C9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.30632 BF_2 4.74 14.87 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30635 BF_2 26.37 0.84 1601 91086669 XP_968223.1 832 3.5e-86 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K2G1 548 1.2e-54 Proteasomal ubiquitin receptor ADRM1 homolog OS=Drosophila melanogaster GN=Rpn13 PE=1 SV=1 PF04683//PF09026//PF03999//PF05460 Proteasome complex subunit Rpn13 ubiquitin receptor//Centromere protein B dimerisation domain//Microtubule associated protein (MAP65/ASE1 family)//Origin recognition complex subunit 6 (ORC6) GO:0000226//GO:0006355//GO:0006260//GO:0000910 microtubule cytoskeleton organization//regulation of transcription, DNA-templated//DNA replication//cytokinesis GO:0003682//GO:0008017//GO:0003677 chromatin binding//microtubule binding//DNA binding GO:0005737//GO:0000775//GO:0045298//GO:0005664//GO:0000785//GO:0005634 cytoplasm//chromosome, centromeric region//tubulin complex//nuclear origin of replication recognition complex//chromatin//nucleus KOG3037 Cell membrane glycoprotein Cluster-8309.30636 BF_2 698.90 5.99 5167 817052050 XP_012254225.1 1951 2.0e-215 PREDICTED: cGMP-dependent 3',5'-cyclic phosphodiesterase-like isoform X2 [Athalia rosae] -- -- -- -- -- K18283 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K18283 P14099 1564 6.1e-172 cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Bos taurus GN=PDE2A PE=1 SV=2 PF05699//PF11590//PF13185//PF00494//PF00233//PF01590//PF13492 hAT family C-terminal dimerisation region//DNA polymerase catalytic subunit Pol//GAF domain//Squalene/phytoene synthase//3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain GO:0007165//GO:0006144//GO:0006260//GO:0009058//GO:0051252 signal transduction//purine nucleobase metabolic process//DNA replication//biosynthetic process//regulation of RNA metabolic process GO:0016740//GO:0004114//GO:0005515//GO:0003887//GO:0046983//GO:0004523 transferase activity//3',5'-cyclic-nucleotide phosphodiesterase activity//protein binding//DNA-directed DNA polymerase activity//protein dimerization activity//RNA-DNA hybrid ribonuclease activity GO:0042575 DNA polymerase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.30639 BF_2 192.70 1.97 4377 478251314 ENN71782.1 3517 0.0e+00 hypothetical protein YQE_11516, partial [Dendroctonus ponderosae]>gi|546673516|gb|ERL85102.1| hypothetical protein D910_02524 [Dendroctonus ponderosae] -- -- -- -- -- K14569 BMS1 ribosome biogenesis protein BMS1 http://www.genome.jp/dbget-bin/www_bget?ko:K14569 Q14692 1364 8.0e-149 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens GN=BMS1 PE=1 SV=1 PF00910//PF10662//PF00004//PF01926//PF08142 RNA helicase//Ethanolamine utilisation - propanediol utilisation//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AARP2CN (NUC121) domain GO:0006576//GO:0042254 cellular biogenic amine metabolic process//ribosome biogenesis GO:0005524//GO:0005525//GO:0003723//GO:0003724 ATP binding//GTP binding//RNA binding//RNA helicase activity GO:0005634 nucleus KOG1951 GTP-binding protein AARP2 involved in 40S ribosome biogenesis Cluster-8309.30640 BF_2 174.73 1.81 4318 478251314 ENN71782.1 3517 0.0e+00 hypothetical protein YQE_11516, partial [Dendroctonus ponderosae]>gi|546673516|gb|ERL85102.1| hypothetical protein D910_02524 [Dendroctonus ponderosae] -- -- -- -- -- K14569 BMS1 ribosome biogenesis protein BMS1 http://www.genome.jp/dbget-bin/www_bget?ko:K14569 Q14692 1364 7.9e-149 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens GN=BMS1 PE=1 SV=1 PF00910//PF10662//PF00004//PF01926//PF08142 RNA helicase//Ethanolamine utilisation - propanediol utilisation//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AARP2CN (NUC121) domain GO:0006576//GO:0042254 cellular biogenic amine metabolic process//ribosome biogenesis GO:0003723//GO:0005525//GO:0005524//GO:0003724 RNA binding//GTP binding//ATP binding//RNA helicase activity GO:0005634 nucleus KOG1951 GTP-binding protein AARP2 involved in 40S ribosome biogenesis Cluster-8309.30641 BF_2 3.00 3.14 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30642 BF_2 8.96 0.46 1110 642935348 XP_008197977.1 417 3.2e-38 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q02157 259 2.7e-21 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30644 BF_2 21.17 0.88 1293 642927027 XP_008195109.1 719 3.6e-73 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170 bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.30646 BF_2 311.82 5.32 2741 642927029 XP_008195110.1 1072 8.8e-114 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AY04 189 8.9e-13 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Rattus norvegicus PE=2 SV=1 PF07961//PF12884//PF00170 MBA1-like protein//Transducer of regulated CREB activity, N terminus//bZIP transcription factor GO:0032979//GO:0051289//GO:0006355 protein insertion into mitochondrial membrane from inner side//protein homotetramerization//regulation of transcription, DNA-templated GO:0008140//GO:0003700//GO:0043565 cAMP response element binding protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005743 transcription factor complex//mitochondrial inner membrane -- -- Cluster-8309.30647 BF_2 319.30 3.04 4683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30648 BF_2 106.47 1.09 4361 642918051 XP_972552.3 3722 0.0e+00 PREDICTED: uncharacterized protein LOC661288 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CXE0 285 1.0e-23 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.30651 BF_2 10.00 1.26 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30654 BF_2 2.00 0.68 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30655 BF_2 1262.67 77.70 967 546682783 ERL92672.1 487 2.1e-46 hypothetical protein D910_09984 [Dendroctonus ponderosae] 642927307 XM_008196993.1 99 3.9576e-42 PREDICTED: Tribolium castaneum hydroxysteroid (17-beta) dehydrogenase 4 (LOC663655), transcript variant X2, mRNA K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 P97852 207 2.6e-15 Peroxisomal multifunctional enzyme type 2 OS=Rattus norvegicus GN=Hsd17b4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4170 2-enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/Peroxisomal 3-ketoacyl-CoA-thiolase, sterol-binding domain and related enzymes Cluster-8309.30656 BF_2 633.13 8.42 3431 91075916 XP_966441.1 3317 0.0e+00 PREDICTED: exocyst complex component 2 [Tribolium castaneum]>gi|270014638|gb|EFA11086.1| hypothetical protein TcasGA2_TC004683 [Tribolium castaneum] -- -- -- -- -- K17637 EXOC2, SEC5 exocyst complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17637 Q9VQQ9 1888 1.1e-209 Exocyst complex component 2 OS=Drosophila melanogaster GN=sec5 PE=2 SV=1 PF04437//PF01833 RINT-1 / TIP-1 family//IPT/TIG domain GO:0048193 Golgi vesicle transport GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG2347 Sec5 subunit of exocyst complex Cluster-8309.30657 BF_2 64.44 0.39 7241 642911196 XP_008199563.1 2708 4.6e-303 PREDICTED: solute carrier family 12 member 4 isoform X1 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.36005e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q63632 2008 2.8e-223 Solute carrier family 12 member 4 OS=Rattus norvegicus GN=Slc12a4 PE=1 SV=1 PF05038//PF00324//PF03522//PF13520 Cytochrome Cytochrome b558 alpha-subunit//Amino acid permease//Solute carrier family 12//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0003333//GO:0006811 transmembrane transport//amino acid transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215//GO:0020037 amino acid transmembrane transporter activity//transporter activity//heme binding GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.30658 BF_2 297.17 15.92 1068 478251086 ENN71562.1 770 3.6e-79 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K04552 UBE2L3, UBCH7 ubiquitin-conjugating enzyme E2 L3 http://www.genome.jp/dbget-bin/www_bget?ko:K04552 Q3MHP1 685 1.1e-70 Ubiquitin-conjugating enzyme E2 L3 OS=Bos taurus GN=UBE2L3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0422 Ubiquitin-protein ligase Cluster-8309.30659 BF_2 713.83 47.49 916 478251087 ENN71563.1 809 9.2e-84 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K04552 UBE2L3, UBCH7 ubiquitin-conjugating enzyme E2 L3 http://www.genome.jp/dbget-bin/www_bget?ko:K04552 P68036 711 8.8e-74 Ubiquitin-conjugating enzyme E2 L3 OS=Homo sapiens GN=UBE2L3 PE=1 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG0422 Ubiquitin-protein ligase Cluster-8309.30660 BF_2 108.00 6.73 958 642921952 XP_008192957.1 501 5.0e-48 PREDICTED: uncharacterized protein LOC103312899 [Tribolium castaneum]>gi|642921954|ref|XP_008192958.1| PREDICTED: uncharacterized protein LOC103312899 [Tribolium castaneum]>gi|270007380|gb|EFA03828.1| hypothetical protein TcasGA2_TC013943 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30663 BF_2 1554.67 12.91 5324 642935831 XP_008198194.1 4497 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 3.7e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00360//PF00621 Phytochrome region//RhoGEF domain GO:0043087//GO:0035023//GO:0009584//GO:0018298//GO:0006355 regulation of GTPase activity//regulation of Rho protein signal transduction//detection of visible light//protein-chromophore linkage//regulation of transcription, DNA-templated GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.30664 BF_2 1242.26 35.84 1737 478263397 ENN81769.1 863 9.6e-90 hypothetical protein YQE_01862, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q26474 259 4.3e-21 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF00041//PF13895//PF16656//PF01108 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Tissue factor GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.30665 BF_2 6.52 0.33 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30666 BF_2 239.00 16.18 905 91077864 XP_972466.1 754 2.2e-77 PREDICTED: glutaredoxin-3 [Tribolium castaneum]>gi|270001471|gb|EEZ97918.1| hypothetical protein TcasGA2_TC000304 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28ID3 534 2.9e-53 Glutaredoxin-3 OS=Xenopus tropicalis GN=glrx3 PE=2 SV=2 PF02966//PF05183//PF00462//PF00085 Mitosis protein DIM1//RNA dependent RNA polymerase//Glutaredoxin//Thioredoxin GO:0000398//GO:0045454//GO:0006118//GO:0006144 mRNA splicing, via spliceosome//cell redox homeostasis//obsolete electron transport//purine nucleobase metabolic process GO:0015035//GO:0009055//GO:0003968 protein disulfide oxidoreductase activity//electron carrier activity//RNA-directed RNA polymerase activity GO:0031379//GO:0005681 RNA-directed RNA polymerase complex//spliceosomal complex KOG0911 Glutaredoxin-related protein Cluster-8309.30669 BF_2 465.06 4.63 4488 91090558 XP_971487.1 1772 9.8e-195 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 751447204 XM_011179427.1 197 6.27962e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1017 1.4e-108 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01128//PF01151//PF07959//PF00483 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//GNS1/SUR4 family//L-fucokinase//Nucleotidyl transferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0050518//GO:0016779//GO:0016772 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups GO:0016021 integral component of membrane -- -- Cluster-8309.30670 BF_2 2.58 0.36 583 332375022 AEE62652.1 276 3.7e-22 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q94519 131 1.0e-06 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-8309.30672 BF_2 307.48 3.97 3524 646706689 KDR13796.1 370 2.9e-32 PDZ domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O54824 231 1.5e-17 Pro-interleukin-16 OS=Mus musculus GN=Il16 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.30673 BF_2 152.00 7.77 1105 642920140 XP_001816345.2 346 5.4e-30 PREDICTED: uncharacterized protein LOC100141670 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03376 139 2.3e-07 Balbiani ring protein 3 OS=Chironomus tentans GN=BR3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30675 BF_2 583.00 17.09 1714 189234686 XP_001811600.1 344 1.4e-29 PREDICTED: regulator of nonsense transcripts 1 [Tribolium castaneum]>gi|270002149|gb|EEZ98596.1| hypothetical protein TcasGA2_TC001115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30677 BF_2 89.91 0.61 6494 332376178 AEE63229.1 915 3.4e-95 unknown [Dendroctonus ponderosae] 642924593 XM_008196134.1 241 3.16087e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.2e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.30678 BF_2 172.26 1.44 5291 642918584 XP_966986.2 1643 1.0e-179 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UVD5 252 8.5e-20 Leucine-rich repeat-containing G-protein coupled receptor 6 OS=Mus musculus GN=Lgr6 PE=2 SV=1 PF07926//PF00560//PF04977//PF16331//PF10392//PF00892//PF13855//PF06005 TPR/MLP1/MLP2-like protein//Leucine Rich Repeat//Septum formation initiator//TolA binding protein trimerisation//Golgi transport complex subunit 5//EamA-like transporter family//Leucine rich repeat//Protein of unknown function (DUF904) GO:0007049//GO:0000917//GO:0043093//GO:0006606//GO:0070206//GO:0006891 cell cycle//barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//protein trimerization//intra-Golgi vesicle-mediated transport GO:0005515 protein binding GO:0005737//GO:0017119//GO:0016020//GO:0016021 cytoplasm//Golgi transport complex//membrane//integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.30680 BF_2 217.62 3.33 3025 642916733 XP_008192400.1 1772 6.6e-195 PREDICTED: homeobox protein araucan isoform X1 [Tribolium castaneum] 642916732 XM_008194178.1 767 0 PREDICTED: Tribolium castaneum homeobox protein araucan (LOC652944), transcript variant X1, mRNA -- -- -- -- Q24248 725 6.9e-75 Homeobox protein araucan OS=Drosophila melanogaster GN=ara PE=1 SV=2 PF00046//PF05920//PF00335//PF04931 Homeobox domain//Homeobox KN domain//Tetraspanin family//DNA polymerase phi GO:0006260//GO:0006351//GO:0006355 DNA replication//transcription, DNA-templated//regulation of transcription, DNA-templated GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.30682 BF_2 42.79 0.47 4093 189235133 XP_966882.2 2395 5.1e-267 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.1e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF00307//PF05366 Calponin homology (CH) domain//Sarcolipin -- -- GO:0005515//GO:0030234 protein binding//enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.30683 BF_2 333.71 24.54 856 642921730 XP_008199303.1 710 2.6e-72 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 540 5.5e-54 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.30685 BF_2 132.15 2.14 2876 642917429 XP_008191194.1 977 9.6e-103 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P84850 780 2.8e-81 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=D2hgdh PE=3 SV=1 PF01565//PF08558//PF02913 FAD binding domain//Telomere repeat binding factor (TRF)//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0042162//GO:0003824//GO:0042803//GO:0050660 oxidoreductase activity//telomeric DNA binding//catalytic activity//protein homodimerization activity//flavin adenine dinucleotide binding -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.30687 BF_2 6.00 1.55 449 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30689 BF_2 77.00 1.90 1982 270009630 EFA06078.1 601 2.6e-59 hypothetical protein TcasGA2_TC008914 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P5N6 237 1.7e-18 ADP-ribosylation factor-like protein 16 OS=Homo sapiens GN=ARL16 PE=1 SV=1 PF08477//PF03193//PF12317//PF11403//PF00025//PF06858//PF00503 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Intraflagellar transport complex B protein 46 C terminal//Yeast metallothionein//ADP-ribosylation factor family//Nucleolar GTP-binding protein 1 (NOG1)//G-protein alpha subunit GO:0007186//GO:0042073//GO:0007264//GO:0010273//GO:0007165//GO:0071585 G-protein coupled receptor signaling pathway//intraciliary transport//small GTPase mediated signal transduction//detoxification of copper ion//signal transduction//detoxification of cadmium ion GO:0004871//GO:0019001//GO:0005525//GO:0046870//GO:0031683//GO:0005507//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//cadmium ion binding//G-protein beta/gamma-subunit complex binding//copper ion binding//GTPase activity -- -- KOG0072 GTP-binding ADP-ribosylation factor-like protein ARL1 Cluster-8309.30691 BF_2 344.00 6.46 2515 91089527 XP_971048.1 1743 1.3e-191 PREDICTED: protein penguin [Tribolium castaneum]>gi|270012590|gb|EFA09038.1| hypothetical protein TcasGA2_TC006751 [Tribolium castaneum] -- -- -- -- -- K14844 PUF6 pumilio homology domain family member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14844 O61345 780 2.4e-81 Protein penguin OS=Drosophila melanogaster GN=pen PE=2 SV=1 PF00651//PF08144//PF00806 BTB/POZ domain//CPL (NUC119) domain//Pumilio-family RNA binding repeat -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2050 Puf family RNA-binding protein Cluster-8309.30692 BF_2 134.09 1.42 4230 728416984 AIY68330.1 1038 1.2e-109 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 450 7.5e-43 Esterase FE4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30694 BF_2 231.77 4.36 2513 91076424 XP_976077.1 2690 1.9e-301 PREDICTED: exostosin-2 [Tribolium castaneum]>gi|270002589|gb|EEZ99036.1| hypothetical protein TcasGA2_TC004910 [Tribolium castaneum] 795266858 XM_012001352.1 75 2.30697e-28 PREDICTED: Mandrillus leucophaeus exostosin glycosyltransferase 2 (EXT2), transcript variant X2, mRNA K02367 EXT2 glucuronyl/N-acetylglucosaminyl transferase EXT2 http://www.genome.jp/dbget-bin/www_bget?ko:K02367 Q9Y169 1909 2.9e-212 Exostosin-2 OS=Drosophila melanogaster GN=Ext2 PE=1 SV=1 PF09258//PF02891 Glycosyl transferase family 64 domain//MIZ/SP-RING zinc finger GO:0015012//GO:0006024 heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process GO:0008270//GO:0016758 zinc ion binding//transferase activity, transferring hexosyl groups GO:0031227//GO:0016021 intrinsic component of endoplasmic reticulum membrane//integral component of membrane KOG1021 Acetylglucosaminyltransferase EXT1/exostosin 1 Cluster-8309.30695 BF_2 3.00 0.79 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30702 BF_2 765.69 5.64 5963 642917952 XP_008198956.1 1655 4.8e-181 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 728 6.1e-75 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.30703 BF_2 76.00 2.49 1564 270015258 EFA11706.1 147 9.1e-07 hypothetical protein TcasGA2_TC001793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01159 Ribosomal protein L6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.30706 BF_2 252.94 4.02 2918 642938573 XP_969296.2 1835 3.1e-202 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum]>gi|642938575|ref|XP_008199847.1| PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum] 195573452 XM_002104672.1 41 2.13302e-09 Drosophila simulans GD21091 (Dsim\GD21091), mRNA K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 1436 2.4e-157 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.30711 BF_2 391.42 1.47 11441 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.70168e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF01059//PF00128//PF00069//PF04043//PF07714//PF09162 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Alpha amylase, catalytic domain//Protein kinase domain//Plant invertase/pectin methylesterase inhibitor//Protein tyrosine kinase//Tap, RNA-binding GO:0005975//GO:0055114//GO:0006120//GO:0006406//GO:0006468 carbohydrate metabolic process//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone//mRNA export from nucleus//protein phosphorylation GO:0043169//GO:0004672//GO:0005524//GO:0003824//GO:0003723//GO:0004857 cation binding//protein kinase activity//ATP binding//catalytic activity//RNA binding//enzyme inhibitor activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG3625 Alpha amylase Cluster-8309.30713 BF_2 93.94 0.52 7817 642919612 XP_008191939.1 2017 6.6e-223 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X4 [Tribolium castaneum] 642919611 XM_008193717.1 171 3.1156e-81 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.6e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF01388//PF12031//PF02257 ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518)//RFX DNA-binding domain GO:0006338//GO:0006355 chromatin remodeling//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0090544 BAF-type complex -- -- Cluster-8309.30714 BF_2 357.52 5.54 2986 189240234 XP_968546.2 3226 0.0e+00 PREDICTED: roquin-1 [Tribolium castaneum] 571504095 XM_006569527.1 254 8.57185e-128 PREDICTED: Apis mellifera roquin (roq), mRNA K15690 RC3H RING finger and CCCH-type zinc finger domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K15690 Q4VGL6 1584 1.7e-174 Roquin-1 OS=Mus musculus GN=Rc3h1 PE=1 SV=1 PF16685//PF13639//PF00097//PF05138//PF14634//PF00642 zinc RING finger of MSL2//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Phenylacetic acid catabolic protein//zinc-RING finger domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0010124 phenylacetate catabolic process GO:0008270//GO:0061630//GO:0046872//GO:0005515 zinc ion binding//ubiquitin protein ligase activity//metal ion binding//protein binding -- -- KOG3161 Predicted E3 ubiquitin ligase Cluster-8309.30716 BF_2 113.00 7.17 946 642931814 XP_008196744.1 982 8.3e-104 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 761 1.4e-79 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30717 BF_2 146.93 1.36 4792 86604731 NP_001034510.1 1110 6.0e-118 transcription factor deformed [Tribolium castaneum]>gi|13241682|gb|AAK16423.1|AF321227_3 Dfd [Tribolium castaneum]>gi|1754686|gb|AAB39355.1| transcription factor Deformed [Tribolium castaneum]>gi|270002806|gb|EEZ99253.1| deformed [Tribolium castaneum] 676432024 XM_009048192.1 82 5.68549e-32 Lottia gigantea hypothetical protein partial mRNA K09304 HOX_4 homeobox protein HoxA/B/C/D4 http://www.genome.jp/dbget-bin/www_bget?ko:K09304 P07548 503 6.0e-49 Homeotic protein deformed OS=Drosophila melanogaster GN=Dfd PE=1 SV=2 PF07244//PF00046 Surface antigen variable number repeat//Homeobox domain -- -- GO:0003677 DNA binding GO:0019867 outer membrane -- -- Cluster-8309.30719 BF_2 1314.00 60.02 1203 642913811 XP_008201169.1 727 3.9e-74 PREDICTED: paired mesoderm homeobox protein 2 [Tribolium castaneum]>gi|270002762|gb|EEZ99209.1| hypothetical protein TcasGA2_TC000527 [Tribolium castaneum] -- -- -- -- -- K09329 PRRX, PMX paired mesoderm homeobox protein http://www.genome.jp/dbget-bin/www_bget?ko:K09329 P54821 294 2.6e-25 Paired mesoderm homeobox protein 1 OS=Homo sapiens GN=PRRX1 PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.30720 BF_2 221.00 35.57 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30721 BF_2 1143.00 47.92 1285 642932726 XP_971981.2 749 1.2e-76 PREDICTED: EF-hand domain-containing protein D2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJ26 523 7.8e-52 EF-hand domain-containing protein D2 homolog OS=Drosophila melanogaster GN=Swip-1 PE=2 SV=1 PF12763//PF13202//PF13499//PF10591//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0041 Predicted Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.30722 BF_2 50.12 0.83 2800 642911817 XP_008200757.1 2573 8.0e-288 PREDICTED: histone-arginine methyltransferase CARMER isoform X1 [Tribolium castaneum]>gi|270014548|gb|EFA10996.1| hypothetical protein TcasGA2_TC004581 [Tribolium castaneum] -- -- -- -- -- K05931 CARM1, PRMT4 histone-arginine methyltransferase CARM1 http://www.genome.jp/dbget-bin/www_bget?ko:K05931 Q174R2 1725 7.1e-191 Histone-arginine methyltransferase CARMER OS=Aedes aegypti GN=CARM1 PE=3 SV=1 PF06484//PF05175//PF08241//PF02932//PF03602//PF03153//PF09606//PF05185 Teneurin Intracellular Region//Methyltransferase small domain//Methyltransferase domain//Neurotransmitter-gated ion-channel transmembrane region//Conserved hypothetical protein 95//Transcription factor IIA, alpha/beta subunit//ARC105 or Med15 subunit of Mediator complex non-fungal//PRMT5 arginine-N-methyltransferase GO:0008152//GO:0007165//GO:0031167//GO:0006479//GO:0006357//GO:0006811//GO:0006367 metabolic process//signal transduction//rRNA methylation//protein methylation//regulation of transcription from RNA polymerase II promoter//ion transport//transcription initiation from RNA polymerase II promoter GO:0001104//GO:0008168 RNA polymerase II transcription cofactor activity//methyltransferase activity GO:0016021//GO:0016592//GO:0016020//GO:0005672 integral component of membrane//mediator complex//membrane//transcription factor TFIIA complex KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.30730 BF_2 12.59 0.96 838 642915229 XP_008190531.1 250 5.6e-19 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 158 1.1e-09 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30732 BF_2 56.26 1.83 1575 91087093 XP_975012.1 944 3.5e-99 PREDICTED: hydroxylysine kinase [Tribolium castaneum]>gi|270009602|gb|EFA06050.1| hypothetical protein TcasGA2_TC008883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RU49 521 1.6e-51 Hydroxylysine kinase OS=Homo sapiens GN=HYKK PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.30733 BF_2 793.74 28.85 1438 91087093 XP_975012.1 944 3.2e-99 PREDICTED: hydroxylysine kinase [Tribolium castaneum]>gi|270009602|gb|EFA06050.1| hypothetical protein TcasGA2_TC008883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RU49 521 1.5e-51 Hydroxylysine kinase OS=Homo sapiens GN=HYKK PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.30737 BF_2 16.00 0.34 2284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3074 BF_2 20.00 0.46 2090 270015748 EFA12196.1 166 7.7e-09 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30740 BF_2 88.00 3.33 1392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30744 BF_2 29.49 1.11 1394 478250865 ENN71354.1 245 3.5e-18 hypothetical protein YQE_11969, partial [Dendroctonus ponderosae] -- -- -- -- -- K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 Q29I35 212 9.7e-16 Armadillo segment polarity protein OS=Drosophila pseudoobscura pseudoobscura GN=arm PE=3 SV=2 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.30745 BF_2 23.35 1.11 1168 189238926 XP_001811313.1 334 1.4e-28 PREDICTED: acyl-CoA-binding domain-containing protein 5A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09177//PF04728 Syntaxin 6, N-terminal//Lipoprotein leucine-zipper GO:0048193 Golgi vesicle transport -- -- GO:0019867//GO:0016020 outer membrane//membrane -- -- Cluster-8309.30746 BF_2 511.03 26.83 1084 642931814 XP_008196744.1 1235 4.4e-133 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 884 9.0e-94 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF06584//PF00067 DIRP//Cytochrome P450 GO:0006351//GO:0055114//GO:0007049 transcription, DNA-templated//oxidation-reduction process//cell cycle GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding GO:0017053 transcriptional repressor complex -- -- Cluster-8309.30747 BF_2 1114.70 7.73 6321 780653487 XP_011691003.1 1653 8.7e-181 PREDICTED: pescadillo homolog [Wasmannia auropunctata] 704508966 XM_010081703.1 86 4.48784e-34 PREDICTED: Pterocles gutturalis pelota homolog (Drosophila) (PELO), mRNA K06965 PELO, DOM34, pelA protein pelota http://www.genome.jp/dbget-bin/www_bget?ko:K06965 P48612 1549 4.1e-170 Protein pelota OS=Drosophila melanogaster GN=pelo PE=2 SV=2 PF06732 Pescadillo N-terminus GO:0042254 ribosome biogenesis -- -- GO:0005730 nucleolus KOG2869 Meiotic cell division protein Pelota/DOM34 Cluster-8309.30748 BF_2 367.13 2.78 5816 546671147 ERL83597.1 1894 9.0e-209 hypothetical protein D910_00703 [Dendroctonus ponderosae]>gi|546674557|gb|ERL85913.1| hypothetical protein D910_03328 [Dendroctonus ponderosae] 704508966 XM_010081703.1 62 9.06551e-21 PREDICTED: Pterocles gutturalis pelota homolog (Drosophila) (PELO), mRNA K14843 PES1, NOP7 pescadillo http://www.genome.jp/dbget-bin/www_bget?ko:K14843 B4KID9 1462 4.6e-160 Pescadillo homolog OS=Drosophila mojavensis GN=GI18209 PE=3 SV=1 PF06732 Pescadillo N-terminus GO:0042254 ribosome biogenesis -- -- GO:0005730 nucleolus KOG2481 Protein required for normal rRNA processing Cluster-8309.30749 BF_2 74.34 0.95 3549 91084469 XP_970666.1 1416 1.5e-153 PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925528|ref|XP_008194588.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925531|ref|XP_008194589.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum] 817200928 XM_012420774.1 171 1.40727e-81 PREDICTED: Orussus abietinus transcription factor Sp1-like (LOC105697447), transcript variant X5, mRNA -- -- -- -- P18722 282 1.9e-23 Gastrula zinc finger protein XlCGF46.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF00096//PF13465//PF13912//PF05191 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Adenylate kinase, active site lid GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0046872//GO:0004017 metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.30750 BF_2 15.00 2.18 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30752 BF_2 26.41 0.65 1984 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05493 ATP synthase subunit H GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.30753 BF_2 28.46 0.51 2607 300303952 ADJ97385.1 1183 1.1e-126 star [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42519 539 2.2e-53 Protein Star OS=Drosophila melanogaster GN=S PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30754 BF_2 728.58 26.98 1417 642923427 XP_008193740.1 1289 3.1e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6JFQ6 393 1.0e-36 Clavesin-1 OS=Rattus norvegicus GN=Clvs1 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.30755 BF_2 811.70 59.07 862 211939884 ACJ13424.1 598 2.5e-59 serpin [Sphenophorus levis] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 426 9.2e-41 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.30756 BF_2 188.30 8.31 1235 211939884 ACJ13424.1 598 3.6e-59 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- P22922 426 1.3e-40 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.30759 BF_2 877.16 13.36 3033 134131322 BAF49604.1 893 5.6e-93 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 490 1.2e-47 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0004553 serine-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.30760 BF_2 4.95 0.51 696 642912323 XP_969456.2 539 1.4e-52 PREDICTED: aldose reductase [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 397 1.7e-37 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30763 BF_2 435.72 6.58 3059 91079058 XP_975148.1 1112 2.3e-118 PREDICTED: ubiquitin domain-containing protein UBFD1 isoform X2 [Tribolium castaneum]>gi|270004196|gb|EFA00644.1| hypothetical protein TcasGA2_TC003520 [Tribolium castaneum] 769860810 XM_011643855.1 58 7.93397e-19 PREDICTED: Pogonomyrmex barbatus ubiquitin domain-containing protein UBFD1-like (LOC105430337), transcript variant X3, mRNA -- -- -- -- Q78JW9 727 4.1e-75 Ubiquitin domain-containing protein UBFD1 OS=Mus musculus GN=Ubfd1 PE=1 SV=2 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG3289 Uncharacterized conserved protein encoded by sequence overlapping the COX4 gene Cluster-8309.30767 BF_2 51.62 3.73 866 4102791 AAD01586.1 136 9.5e-06 TFPIbeta [Mus musculus] -- -- -- -- -- -- -- -- -- O54819 136 3.9e-07 Tissue factor pathway inhibitor OS=Mus musculus GN=Tfpi PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.30768 BF_2 49.00 4.72 721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3077 BF_2 46.62 1.39 1695 642936411 XP_972396.2 620 1.4e-61 PREDICTED: zinc finger protein 714 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2VDP4 326 7.1e-29 Zinc finger protein 567 OS=Bos taurus GN=ZNF567 PE=2 SV=1 PF00649//PF07776//PF00096//PF13912//PF04810//PF02892//PF16622//PF13465 Copper fist DNA binding domain//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//C2H2-type zinc finger//Sec23/Sec24 zinc finger//BED zinc finger//zinc-finger C2H2-type//Zinc-finger double domain GO:0006355//GO:0006888//GO:0006886 regulation of transcription, DNA-templated//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0003700//GO:0046872//GO:0003677//GO:0005507 zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//DNA binding//copper ion binding GO:0005634//GO:0030127//GO:0005667 nucleus//COPII vesicle coat//transcription factor complex -- -- Cluster-8309.30771 BF_2 24.02 0.45 2528 478260276 ENN80028.1 271 6.2e-21 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2EI20 183 4.1e-12 RE1-silencing transcription factor OS=Danio rerio GN=rest PE=2 SV=1 PF02150//PF00096//PF13465//PF04988//PF03348//PF06309//PF07649 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//Serine incorporator (Serinc)//Torsin//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0005524//GO:0003899//GO:0003677//GO:0046872//GO:0047134 ATP binding//DNA-directed RNA polymerase activity//DNA binding//metal ion binding//protein-disulfide reductase activity GO:0005634//GO:0005730//GO:0016020 nucleus//nucleolus//membrane KOG1721 FOG: Zn-finger Cluster-8309.30772 BF_2 373.00 8.92 2036 332372963 AEE61623.1 1106 7.5e-118 unknown [Dendroctonus ponderosae]>gi|478254924|gb|ENN75158.1| hypothetical protein YQE_08271, partial [Dendroctonus ponderosae]>gi|546673351|gb|ERL84977.1| hypothetical protein D910_02400 [Dendroctonus ponderosae] 195122951 XM_002005938.1 132 3.83762e-60 Drosophila mojavensis GI20775 (Dmoj\GI20775), mRNA -- -- -- -- Q28Y69 882 2.9e-93 Zinc finger CCCH domain-containing protein 15 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA21225 PE=3 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- KOG1763 Uncharacterized conserved protein, contains CCCH-type Zn-finger Cluster-8309.30773 BF_2 63.00 2.93 1188 478255831 ENN76039.1 889 6.3e-93 hypothetical protein YQE_07412, partial [Dendroctonus ponderosae] -- -- -- -- -- K15456 KTI12 protein KTI12 http://www.genome.jp/dbget-bin/www_bget?ko:K15456 Q0P457 497 7.4e-49 Protein KTI12 homolog OS=Danio rerio GN=kti12 PE=2 SV=2 PF00437//PF01591//PF01583 Type II/IV secretion system protein//6-phosphofructo-2-kinase//Adenylylsulphate kinase GO:0006144//GO:0000103//GO:0006810//GO:0006013//GO:0006000 purine nucleobase metabolic process//sulfate assimilation//transport//mannose metabolic process//fructose metabolic process GO:0005524//GO:0003873//GO:0004020 ATP binding//6-phosphofructo-2-kinase activity//adenylylsulfate kinase activity -- -- KOG3062 RNA polymerase II elongator associated protein Cluster-8309.30774 BF_2 243.00 9.56 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30775 BF_2 223.86 2.01 4946 270007830 EFA04278.1 3034 0.0e+00 hypothetical protein TcasGA2_TC014568 [Tribolium castaneum] 642924109 XM_008195787.1 538 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1466 1.3e-160 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF07714//PF00069//PF06293//PF07463 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//NUMOD4 motif GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016788//GO:0016773 protein kinase activity//ATP binding//hydrolase activity, acting on ester bonds//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.30778 BF_2 1818.12 8.70 9033 270006069 EFA02517.1 3497 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 703 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2346 2.2e-262 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF02135//PF09030//PF08214//PF16987//PF02172//PF06371//PF09468//PF00569//PF07711//PF12437//PF00439 TAZ zinc finger//Creb binding//Histone acetylation protein//KIX domain//KIX domain//Diaphanous GTPase-binding Domain//Ydr279p protein family (RNase H2 complex component)//Zinc finger, ZZ type//Rab geranylgeranyl transferase alpha-subunit, insert domain//Glutamine synthetase type III N terminal//Bromodomain GO:0009252//GO:0006807//GO:0030036//GO:0006355//GO:0042967//GO:0016573 peptidoglycan biosynthetic process//nitrogen compound metabolic process//actin cytoskeleton organization//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//histone acetylation GO:0017048//GO:0004402//GO:0005515//GO:0003713//GO:0004356//GO:0004663//GO:0003712//GO:0008270//GO:0003779 Rho GTPase binding//histone acetyltransferase activity//protein binding//transcription coactivator activity//glutamate-ammonia ligase activity//Rab geranylgeranyltransferase activity//transcription cofactor activity//zinc ion binding//actin binding GO:0000123//GO:0005968//GO:0005667//GO:0005634 histone acetyltransferase complex//Rab-protein geranylgeranyltransferase complex//transcription factor complex//nucleus KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.30780 BF_2 8046.25 106.86 3437 91078836 XP_971451.1 1905 2.8e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 1.81296e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.4e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0005975//GO:0006508//GO:0008152 carbohydrate metabolic process//proteolysis//metabolic process GO:0016805//GO:0008237//GO:0034701//GO:0016787//GO:0004560 dipeptidase activity//metallopeptidase activity//tripeptidase activity//hydrolase activity//alpha-L-fucosidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.30784 BF_2 38.64 0.82 2266 662618229 BAP15928.1 851 3.1e-88 ultraspiracle 1 isoform [Henosepilachna vigintioctopunctata] 662618236 AB506667.1 134 3.30766e-61 Harmonia axyridis HaUSP-1 mRNA for ultraspiracle 1 isoform, complete cds K14030 NR2B4, usp nuclear receptor subfamily 2 group B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14030 P54779 451 3.1e-43 Protein ultraspiracle homolog OS=Manduca sexta GN=USP PE=2 SV=1 PF00105 Zinc finger, C4 type (two domains) GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.30785 BF_2 9.00 2.50 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30786 BF_2 96.14 0.83 5129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30788 BF_2 8.00 4.66 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30791 BF_2 15.00 0.39 1907 568260112 ETN67895.1 170 2.4e-09 hypothetical protein AND_000276 [Anopheles darlingi] -- -- -- -- -- -- -- -- -- Q9GPH3 163 6.4e-10 Activating transcription factor of chaperone OS=Bombyx mori GN=ATFC PE=2 SV=1 PF00170//PF07716//PF16752 bZIP transcription factor//Basic region leucine zipper//Tubulin-specific chaperone C N-terminal domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0015631 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//tubulin binding GO:0005667//GO:0045298 transcription factor complex//tubulin complex KOG4571 Activating transcription factor 4 Cluster-8309.30792 BF_2 1143.40 9.15 5515 478258247 ENN78376.1 8921 0.0e+00 hypothetical protein YQE_05177, partial [Dendroctonus ponderosae] 642938178 XM_961838.2 1843 0 PREDICTED: Tribolium castaneum pre-mRNA-processing-splicing factor 8 (LOC655310), mRNA K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12856 Q6P2Q9 8605 0.0e+00 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 PF01398//PF08083//PF10596//PF10147//PF10597//PF10598 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//PROCN (NUC071) domain//U6-snRNA interacting domain of PrP8//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//U5-snRNA binding site 2 of PrP8//RNA recognition motif of the spliceosomal PrP8 GO:0007049//GO:0000398 cell cycle//mRNA splicing, via spliceosome GO:0003723//GO:0017070//GO:0030623//GO:0005515 RNA binding//U6 snRNA binding//U5 snRNA binding//protein binding GO:0005634 nucleus KOG1795 U5 snRNP spliceosome subunit Cluster-8309.30793 BF_2 137.02 2.37 2707 91084685 XP_968610.1 2003 9.6e-222 PREDICTED: uncharacterized protein CG3556 [Tribolium castaneum]>gi|270008929|gb|EFA05377.1| hypothetical protein TcasGA2_TC015544 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W4K2 1115 3.7e-120 Uncharacterized protein CG3556 OS=Drosophila melanogaster GN=CG3556 PE=2 SV=1 PF07678//PF00983//PF01122//PF00432 A-macroglobulin complement component//Tymovirus coat protein//Eukaryotic cobalamin-binding protein//Prenyltransferase and squalene oxidase repeat GO:0015889 cobalamin transport GO:0003824//GO:0031419//GO:0005198 catalytic activity//cobalamin binding//structural molecule activity GO:0019028//GO:0005615 viral capsid//extracellular space -- -- Cluster-8309.30794 BF_2 20.98 1.21 1010 91084685 XP_968610.1 1182 5.7e-127 PREDICTED: uncharacterized protein CG3556 [Tribolium castaneum]>gi|270008929|gb|EFA05377.1| hypothetical protein TcasGA2_TC015544 [Tribolium castaneum] -- -- -- -- -- K14615 GIF, IF gastric intrinsic factor http://www.genome.jp/dbget-bin/www_bget?ko:K14615 Q9W4K2 600 7.2e-61 Uncharacterized protein CG3556 OS=Drosophila melanogaster GN=CG3556 PE=2 SV=1 PF07678//PF00983//PF00432//PF01122 A-macroglobulin complement component//Tymovirus coat protein//Prenyltransferase and squalene oxidase repeat//Eukaryotic cobalamin-binding protein GO:0015889 cobalamin transport GO:0005198//GO:0031419//GO:0003824 structural molecule activity//cobalamin binding//catalytic activity GO:0005615//GO:0019028 extracellular space//viral capsid -- -- Cluster-8309.30795 BF_2 360.17 4.86 3390 642914172 XP_008201574.1 2030 8.9e-225 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 826 1.5e-86 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF15182//PF01738 Otospiralin//Dienelactone hydrolase family GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.30796 BF_2 31.54 0.50 2903 642914172 XP_008201574.1 1663 2.8e-182 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 574 2.1e-57 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF15182//PF01738 Otospiralin//Dienelactone hydrolase family GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.30798 BF_2 95.18 1.05 4068 820805580 AKG92781.1 3212 0.0e+00 trachealess [Leptinotarsa decemlineata] 820805579 KP147944.1 644 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1107 4.7e-119 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00010//PF04551//PF08447//PF00989 Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold//PAS fold GO:0006355//GO:0016114//GO:0055114 regulation of transcription, DNA-templated//terpenoid biosynthetic process//oxidation-reduction process GO:0046983//GO:0005515//GO:0046429 protein dimerization activity//protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.3080 BF_2 9.00 0.32 1473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30804 BF_2 419.40 3.36 5510 642918562 XP_008199292.1 1526 4.0e-166 PREDICTED: large proline-rich protein BAG6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH17 362 1.6e-32 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF07469//PF00240//PF14560 Domain of unknown function (DUF1518)//Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4248 Ubiquitin-like protein, regulator of apoptosis Cluster-8309.30807 BF_2 36.78 0.37 4407 91093869 XP_967782.1 5988 0.0e+00 PREDICTED: cytoplasmic FMR1-interacting protein [Tribolium castaneum]>gi|270014526|gb|EFA10974.1| hypothetical protein TcasGA2_TC004140 [Tribolium castaneum] 817207709 XM_012424413.1 589 0 PREDICTED: Orussus abietinus cytoplasmic FMR1-interacting protein (LOC105699430), transcript variant X3, mRNA K05749 CYFIP cytoplasmic FMR1 interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05749 Q9VF87 5266 0.0e+00 Cytoplasmic FMR1-interacting protein OS=Drosophila melanogaster GN=Sra-1 PE=1 SV=1 -- -- -- -- -- -- GO:0005737 cytoplasm KOG3534 p53 inducible protein PIR121 Cluster-8309.30808 BF_2 812.00 14.22 2676 826136069 AKJ26288.1 1814 7.8e-200 hunchback [Diabrotica virgifera virgifera] 113206057 NM_001044628.1 45 1.16847e-11 Tribolium castaneum hunchback (Hb), mRNA K09213 HB hunchback http://www.genome.jp/dbget-bin/www_bget?ko:K09213 Q01791 1360 1.4e-148 Protein hunchback OS=Tribolium castaneum GN=hb PE=3 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.30809 BF_2 234.95 3.62 3006 -- -- -- -- -- 462464129 APGK01005035.1 75 2.76414e-28 Dendroctonus ponderosae Seq01005037, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30810 BF_2 65.87 0.75 3958 91078836 XP_971451.1 1905 3.3e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 2.09069e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.6e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0006508//GO:0005975//GO:0008152 proteolysis//carbohydrate metabolic process//metabolic process GO:0008237//GO:0016805//GO:0004560//GO:0016787//GO:0034701 metallopeptidase activity//dipeptidase activity//alpha-L-fucosidase activity//hydrolase activity//tripeptidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.30811 BF_2 516.00 37.62 861 91087767 XP_975031.1 1032 1.2e-109 PREDICTED: vacuolar protein sorting-associated protein 28 homolog [Tribolium castaneum]>gi|270010745|gb|EFA07193.1| hypothetical protein TcasGA2_TC010199 [Tribolium castaneum] -- -- -- -- -- K12184 VPS28 ESCRT-I complex subunit VPS28 http://www.genome.jp/dbget-bin/www_bget?ko:K12184 Q9V359 850 6.3e-90 Vacuolar protein sorting-associated protein 28 homolog OS=Drosophila melanogaster GN=Vps28 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3284 Vacuolar sorting protein VPS28 Cluster-8309.30814 BF_2 210.47 4.58 2210 731286412 XP_010611509.1 690 1.4e-69 PREDICTED: LOW QUALITY PROTEIN: histone H3.3 [Fukomys damarensis] 805824145 XM_003708049.2 153 8.83973e-72 PREDICTED: Megachile rotundata histone H3.3 (LOC100883938), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 Q6P823 676 2.4e-69 Histone H3.3 OS=Xenopus tropicalis GN=TGas113e22.1 PE=1 SV=3 PF00125//PF15715//PF08219 Core histone H2A/H2B/H3/H4//PCNA-associated factor//Outer membrane protein TOM13 GO:0006974//GO:0051726 cellular response to DNA damage stimulus//regulation of cell cycle GO:0003677 DNA binding GO:0005741 mitochondrial outer membrane KOG1745 Histones H3 and H4 Cluster-8309.30815 BF_2 455.66 37.17 800 642931814 XP_008196744.1 829 3.9e-86 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 546 1.0e-54 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.30816 BF_2 56.54 2.59 1200 741829858 AJA91073.1 806 2.7e-83 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 517 3.6e-51 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF08127 Cytochrome P450//Peptidase family C1 propeptide GO:0050790//GO:0055114//GO:0006508 regulation of catalytic activity//oxidation-reduction process//proteolysis GO:0005506//GO:0004197//GO:0020037//GO:0016705 iron ion binding//cysteine-type endopeptidase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.30817 BF_2 530.15 29.26 1045 189236526 XP_975464.2 474 7.4e-45 PREDICTED: spondin-1 [Tribolium castaneum]>gi|270005305|gb|EFA01753.1| hypothetical protein TcasGA2_TC007351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 143 7.3e-08 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 -- -- -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.30819 BF_2 113.46 1.41 3644 478252006 ENN72441.1 2780 0.0e+00 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1406 9.0e-154 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF05173//PF01433 Dihydrodipicolinate reductase, C-terminus//Peptidase family M1 GO:0055114//GO:0009085//GO:0009089 oxidation-reduction process//lysine biosynthetic process//lysine biosynthetic process via diaminopimelate GO:0008270//GO:0008237//GO:0008839 zinc ion binding//metallopeptidase activity//4-hydroxy-tetrahydrodipicolinate reductase -- -- -- -- Cluster-8309.30820 BF_2 165.92 2.29 3313 642929984 XP_008196053.1 2642 9.5e-296 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 317 9.06196e-163 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1596 7.6e-176 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF00211//PF07714//PF00069//PF06330//PF07701 Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Protein kinase domain//Trichodiene synthase (TRI5)//Heme NO binding associated GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0016114//GO:0006144//GO:0006468//GO:0016106 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//terpenoid biosynthetic process//purine nucleobase metabolic process//protein phosphorylation//sesquiterpenoid biosynthetic process GO:0004383//GO:0016849//GO:0004672//GO:0045482//GO:0005524 guanylate cyclase activity//phosphorus-oxygen lyase activity//protein kinase activity//trichodiene synthase activity//ATP binding -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30821 BF_2 51.00 0.93 2591 270009782 EFA06230.1 311 1.5e-25 hypothetical protein TcasGA2_TC009079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.30823 BF_2 101.00 3.57 1470 21218350 AAM44045.1 2268 9.8e-253 arylphorin-like hexamerin [Apriona germari] 21218349 AF509880.1 841 0 Apriona germari arylphorin-like hexamerin mRNA, complete cds -- -- -- -- Q25641 812 2.7e-85 Allergen Cr-PI OS=Periplaneta americana PE=1 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-8309.30824 BF_2 429.33 9.24 2230 642913109 XP_008201396.1 803 1.1e-82 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 167 1.47183e-79 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 651 1.9e-66 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4406 CDC42 Rho GTPase-activating protein Cluster-8309.30825 BF_2 217.75 2.85 3482 642913109 XP_008201396.1 2378 4.1e-265 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 6.33227e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 1430 1.4e-156 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.30826 BF_2 221.90 3.03 3350 642913109 XP_008201396.1 2378 3.9e-265 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 6.08971e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 1430 1.4e-156 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.30827 BF_2 7.07 0.33 1195 642912555 XP_008200909.1 310 8.8e-26 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q8BSF4 184 1.5e-12 Phosphatidylserine decarboxylase proenzyme OS=Mus musculus GN=Pisd PE=2 SV=1 -- -- GO:0008654//GO:0046486//GO:0006544//GO:0006563//GO:0006566 phospholipid biosynthetic process//glycerolipid metabolic process//glycine metabolic process//L-serine metabolic process//threonine metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.30828 BF_2 1160.76 32.10 1800 642927471 XP_008195286.1 1450 8.5e-158 PREDICTED: peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K18200 PAL peptidylamidoglycolate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K18200 Q9W1L5 1013 1.7e-108 Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 OS=Drosophila melanogaster GN=Pal2 PE=1 SV=2 PF11837//PF01436//PF01983 Domain of unknown function (DUF3357)//NHL repeat//Guanylyl transferase CofC like GO:0006012//GO:0005985//GO:0005982 galactose metabolic process//sucrose metabolic process//starch metabolic process GO:0004564//GO:0016779//GO:0005515//GO:0004575 beta-fructofuranosidase activity//nucleotidyltransferase activity//protein binding//sucrose alpha-glucosidase activity GO:0017177 glucosidase II complex KOG3567 Peptidylglycine alpha-amidating monooxygenase Cluster-8309.30829 BF_2 13.00 1.50 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3083 BF_2 3.00 1.75 355 194374393 BAG57092.1 435 8.3e-41 unnamed protein product [Homo sapiens] 223890142 NG_005980.3 355 0 Homo sapiens ribosomal protein S28 pseudogene 7 (RPS28P7) on chromosome 11 K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 Q6QAT1 276 9.4e-24 40S ribosomal protein S28 OS=Sus scrofa GN=RPS28 PE=1 SV=2 PF01200 Ribosomal protein S28e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-8309.30830 BF_2 75.50 0.77 4376 642930372 XP_008196370.1 2316 7.9e-258 PREDICTED: mothers against decapentaplegic homolog 3 [Tribolium castaneum] 705688348 XM_010123009.1 125 6.47809e-56 PREDICTED: Chlamydotis macqueenii SMAD family member 2 (SMAD2), transcript variant X2, mRNA K04500 SMAD2_3 mothers against decapentaplegic homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K04500 P84024 1609 3.1e-177 Mothers against decapentaplegic homolog 3 OS=Sus scrofa GN=SMAD3 PE=2 SV=1 PF10401//PF03166//PF03165 Interferon-regulatory factor 3//MH2 domain//MH1 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.30835 BF_2 264.43 2.24 5228 642918984 XP_008191685.1 4728 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X6 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.63074e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122//PF05109 E1-E2 ATPase//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.30836 BF_2 9.74 0.35 1464 642936428 XP_008198430.1 773 2.2e-79 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462294748 APGK01052997.1 59 1.0431e-19 Dendroctonus ponderosae Seq01053007, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 246 1.2e-19 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.30837 BF_2 112.63 2.79 1974 642923135 XP_008193624.1 380 1.1e-33 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Tribolium castaneum] 642923144 XM_008195407.1 257 1.21137e-129 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X8, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30838 BF_2 58.73 0.39 6552 642914795 XP_008190356.1 5242 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 1776 2.0e-196 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF00107//PF00975 Zinc-binding dehydrogenase//Thioesterase domain GO:0055114//GO:0009058 oxidation-reduction process//biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.30839 BF_2 976.12 9.53 4570 642925855 XP_008190573.1 1956 4.6e-216 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K06171 NCSTN nicastrin http://www.genome.jp/dbget-bin/www_bget?ko:K06171 Q9VC27 1092 2.9e-117 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF05450//PF00328 Nicastrin//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0016485//GO:0006771 hexachlorocyclohexane metabolic process//protein processing//riboflavin metabolic process GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30841 BF_2 1523.00 13.50 5008 270010959 EFA07407.1 3013 0.0e+00 protein C kinase 98E-like protein [Tribolium castaneum] 817193422 XM_012416747.1 273 3.96043e-138 PREDICTED: Orussus abietinus protein kinase C (LOC105695297), transcript variant X5, mRNA K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 Q16975 2286 1.1e-255 Calcium-independent protein kinase C OS=Aplysia californica GN=PRKC2 PE=1 SV=1 PF00130//PF00069//PF06293//PF00433//PF00628//PF07714//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//PHD-finger//Protein tyrosine kinase//C2 domain GO:0035556//GO:0016310//GO:0006468//GO:0009069 intracellular signal transduction//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0004672//GO:0016773//GO:0005515//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.30843 BF_2 1948.50 53.00 1825 478249999 ENN70505.1 1859 3.2e-205 hypothetical protein YQE_12681, partial [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 761 2.8e-79 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.30845 BF_2 41.00 3.46 783 642922790 XP_008193326.1 136 8.6e-06 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06357 Omega-atracotoxin GO:0009405//GO:0006952//GO:0006810 pathogenesis//defense response//transport GO:0019855 calcium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.30846 BF_2 12.08 0.55 1209 478255595 ENN75809.1 687 1.7e-69 hypothetical protein YQE_07645, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.30847 BF_2 22.58 0.84 1418 270009017 EFA05465.1 753 4.5e-77 hypothetical protein TcasGA2_TC015648 [Tribolium castaneum] 462343094 APGK01035499.1 48 1.31516e-13 Dendroctonus ponderosae Seq01035509, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02284 Cytochrome c oxidase subunit Va GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane -- -- Cluster-8309.30848 BF_2 4.65 1.38 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- -- -- Cluster-8309.30849 BF_2 19.36 0.69 1462 642937919 XP_008199130.1 1072 4.7e-114 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9B9 311 3.4e-27 Choline transporter-like protein 1 OS=Torpedo marmorata GN=slc44a1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.30854 BF_2 9.91 0.37 1401 662195663 XP_008470831.1 715 1.1e-72 PREDICTED: ubiquitin-conjugating enzyme E2-22 kDa [Diaphorina citri] 642916082 XM_966235.3 157 3.31774e-74 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2-22 kDa (LOC659971), mRNA K04649 HIP2, UBC1 ubiquitin-conjugating enzyme (huntingtin interacting protein 2) http://www.genome.jp/dbget-bin/www_bget?ko:K04649 P52486 646 4.6e-66 Ubiquitin-conjugating enzyme E2-22 kDa OS=Drosophila melanogaster GN=UbcD4 PE=1 SV=2 PF05773//PF15461//PF05743 RWD domain//Beta-carotene 15,15'-dioxygenase//UEV domain GO:0015031//GO:0055114//GO:0006464 protein transport//oxidation-reduction process//cellular protein modification process GO:0005515//GO:0016702 protein binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen -- -- KOG0418 Ubiquitin-protein ligase Cluster-8309.30855 BF_2 409.27 5.28 3527 478258440 ENN78530.1 845 2.4e-87 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q55BM1 131 6.1e-06 Probable inactive protein kinase DDB_G0270444 OS=Dictyostelium discoideum GN=DDB_G0270444 PE=1 SV=1 PF07851//PF05279//PF01442//PF05478//PF01496//PF03938//PF07464//PF08030//PF02601//PF08702 TMPIT-like protein//Aspartyl beta-hydroxylase N-terminal region//Apolipoprotein A1/A4/E domain//Prominin//V-type ATPase 116kDa subunit family//Outer membrane protein (OmpH-like)//Apolipophorin-III precursor (apoLp-III)//Ferric reductase NAD binding domain//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0055114//GO:0015992//GO:0006869//GO:0015991//GO:0042157//GO:0006308//GO:0030168 protein polymerization//signal transduction//oxidation-reduction process//proton transport//lipid transport//ATP hydrolysis coupled proton transport//lipoprotein metabolic process//DNA catabolic process//platelet activation GO:0051082//GO:0015078//GO:0005102//GO:0008855//GO:0016491//GO:0008289//GO:0030674 unfolded protein binding//hydrogen ion transmembrane transporter activity//receptor binding//exodeoxyribonuclease VII activity//oxidoreductase activity//lipid binding//protein binding, bridging GO:0016021//GO:0005577//GO:0009318//GO:0033179//GO:0005576//GO:0016020 integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//proton-transporting V-type ATPase, V0 domain//extracellular region//membrane -- -- Cluster-8309.30857 BF_2 349.44 3.60 4351 607367304 EZA61451.1 490 4.3e-46 Serine/arginine-rich splicing factor, partial [Cerapachys biroi] 195401199 XM_002059166.1 102 3.93159e-43 Drosophila virilis GJ16161 (Dvir\GJ16161), mRNA K12891 SFRS2 splicing factor, arginine/serine-rich 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12891 Q06A98 418 3.9e-39 Serine/arginine-rich splicing factor 2 OS=Sus scrofa GN=SRSF2 PE=2 SV=1 PF00076//PF03106//PF00042//PF04805//PF06495//PF05001 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//WRKY DNA -binding domain//Globin//E10-like protein conserved region//Fruit fly transformer protein//RNA polymerase Rpb1 C-terminal repeat GO:0006355//GO:0055114//GO:0046660//GO:0006397//GO:0006366 regulation of transcription, DNA-templated//oxidation-reduction process//female sex differentiation//mRNA processing//transcription from RNA polymerase II promoter GO:0003676//GO:0043565//GO:0016972//GO:0003700//GO:0020037//GO:0003677//GO:0019825 nucleic acid binding//sequence-specific DNA binding//thiol oxidase activity//transcription factor activity, sequence-specific DNA binding//heme binding//DNA binding//oxygen binding GO:0005634//GO:0005665//GO:0005667 nucleus//DNA-directed RNA polymerase II, core complex//transcription factor complex KOG4207 Predicted splicing factor, SR protein superfamily Cluster-8309.30858 BF_2 77.55 0.67 5121 546671618 ERL83852.1 1520 1.9e-165 hypothetical protein D910_01119, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30859 BF_2 189.50 3.38 2631 642918375 XP_008200060.1 2382 1.1e-265 PREDICTED: ankyrin-2-like isoform X5 [Tribolium castaneum] 836709203 XM_012933675.1 92 8.57033e-38 PREDICTED: Sorex araneus ankyrin 2, neuronal (ANK2), mRNA K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 G5E8K5 1191 5.5e-129 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF00531//PF04281 Death domain//Mitochondrial import receptor subunit Tom22 GO:0006886//GO:0007165 intracellular protein transport//signal transduction GO:0005515 protein binding GO:0005741 mitochondrial outer membrane KOG4177 Ankyrin Cluster-8309.30861 BF_2 662.33 2.75 10346 642928433 XP_008193783.1 6548 0.0e+00 PREDICTED: proteasome activator complex subunit 4 [Tribolium castaneum]>gi|270010813|gb|EFA07261.1| hypothetical protein TcasGA2_TC013292 [Tribolium castaneum] -- -- -- -- -- K06699 PSME4 proteasome activator subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06699 Q14997 3168 0.0e+00 Proteasome activator complex subunit 4 OS=Homo sapiens GN=PSME4 PE=1 SV=2 PF02985//PF01193//PF06743//PF01000 HEAT repeat//RNA polymerase Rpb3/Rpb11 dimerisation domain//FAST kinase-like protein, subdomain 1//RNA polymerase Rpb3/RpoA insert domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0004672//GO:0003899//GO:0046983//GO:0005515 protein kinase activity//DNA-directed RNA polymerase activity//protein dimerization activity//protein binding GO:0005730 nucleolus KOG1521 RNA polymerase I and III, subunit RPA40/RPC40 Cluster-8309.30862 BF_2 1.05 0.88 329 332372889 AEE61586.1 201 1.0e-13 unknown [Dendroctonus ponderosae]>gi|478253022|gb|ENN73402.1| hypothetical protein YQE_09964, partial [Dendroctonus ponderosae] -- -- -- -- -- K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q99437 176 3.4e-12 V-type proton ATPase 21 kDa proteolipid subunit OS=Homo sapiens GN=ATP6V0B PE=2 SV=1 PF00137//PF00771 ATP synthase subunit C//FHIPEP family GO:0015991//GO:0009306//GO:0015992 ATP hydrolysis coupled proton transport//protein secretion//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016020//GO:0033177 membrane//proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.30864 BF_2 342.32 3.19 4772 478256425 ENN76612.1 690 3.0e-69 hypothetical protein YQE_06869, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1LWH4 352 1.9e-31 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF00829//PF08774 Ribosomal prokaryotic L21 protein//VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds GO:0005840 ribosome KOG2143 Uncharacterized conserved protein Cluster-8309.30865 BF_2 326.50 52.35 548 642920083 XP_008192197.1 437 7.5e-41 PREDICTED: glycogen synthase kinase-3 beta isoform X2 [Tribolium castaneum] 645029971 XM_008210300.1 55 6.28028e-18 PREDICTED: Nasonia vitripennis glycogen synthase kinase-3 beta (LOC100117808), transcript variant X7, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P49841 319 1.5e-28 Glycogen synthase kinase-3 beta OS=Homo sapiens GN=GSK3B PE=1 SV=2 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0658 Glycogen synthase kinase-3 Cluster-8309.30867 BF_2 1483.43 14.92 4445 91081429 XP_973458.1 2939 0.0e+00 PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|642920877|ref|XP_008192597.1| PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|270006127|gb|EFA02575.1| hypothetical protein TcasGA2_TC008293 [Tribolium castaneum] 749790449 XM_011150162.1 133 2.35029e-60 PREDICTED: Harpegnathos saltator ATP-binding cassette sub-family G member 4 (LOC105188614), mRNA K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 1631 8.9e-180 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 PF03193//PF00005//PF13304//PF01926//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0016887//GO:0005525//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.30868 BF_2 346.00 5.67 2841 91095245 XP_970564.1 805 8.3e-83 PREDICTED: E3 ubiquitin-protein ligase RING1 [Tribolium castaneum]>gi|270017230|gb|EFA13676.1| hypothetical protein TcasGA2_TC001392 [Tribolium castaneum] 560952652 XM_006198790.1 113 1.9618e-49 PREDICTED: Vicugna pacos ring finger protein 2 (RNF2), mRNA K10695 RNF1_2 E3 ubiquitin-protein ligase RNF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10695 Q66J69 674 5.3e-69 E3 ubiquitin-protein ligase RING2-A OS=Xenopus laevis GN=rnf2-a PE=2 SV=1 PF02891//PF01396//PF06624//PF13639//PF17123//PF12678//PF14634//PF14372//PF17121//PF00097//PF11789 MIZ/SP-RING zinc finger//Topoisomerase DNA binding C4 zinc finger//Ribosome associated membrane protein RAMP4//Ring finger domain//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Domain of unknown function (DUF4413)//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit GO:0006265 DNA topological change GO:0008270//GO:0046872//GO:0003677//GO:0005515//GO:0003916 zinc ion binding//metal ion binding//DNA binding//protein binding//DNA topoisomerase activity GO:0005694//GO:0005783 chromosome//endoplasmic reticulum KOG0311 Predicted E3 ubiquitin ligase Cluster-8309.30869 BF_2 321.19 3.11 4612 255918127 NP_001157610.1 1687 7.2e-185 tramtrack [Tribolium castaneum]>gi|642921896|ref|XP_008192935.1| PREDICTED: tramtrack isoform X1 [Tribolium castaneum] 751794272 XR_852685.1 49 1.20951e-13 PREDICTED: Bactrocera dorsalis polyhomeotic-proximal chromatin protein-like (LOC105228656), transcript variant X5, misc_RNA K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 578 1.2e-57 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF13912//PF02178//PF13465//PF00096 BTB/POZ domain//C2H2-type zinc finger//AT hook motif//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.30870 BF_2 429.77 2.38 7849 270000975 EEZ97422.1 5016 0.0e+00 hypothetical protein TcasGA2_TC011252 [Tribolium castaneum] 662206951 XM_008478733.1 135 3.21821e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 4249 0.0e+00 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF03079//PF01648//PF00008//PF01106 ARD/ARD' family//4'-phosphopantetheinyl transferase superfamily//EGF-like domain//NifU-like domain GO:0015940//GO:0016226//GO:0055114 pantothenate biosynthetic process//iron-sulfur cluster assembly//oxidation-reduction process GO:0008897//GO:0005515//GO:0010309//GO:0005506//GO:0000287//GO:0051536 holo-[acyl-carrier-protein] synthase activity//protein binding//acireductone dioxygenase [iron(II)-requiring] activity//iron ion binding//magnesium ion binding//iron-sulfur cluster binding -- -- -- -- Cluster-8309.30871 BF_2 1430.51 16.01 4024 642936745 XP_008198563.1 3125 0.0e+00 PREDICTED: neurexin-4 isoform X2 [Tribolium castaneum] 662206951 XM_008478733.1 135 1.6434e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 2433 8.1e-273 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF00008//PF00190//PF01106//PF03079 EGF-like domain//Cupin//NifU-like domain//ARD/ARD' family GO:0016226//GO:0055114 iron-sulfur cluster assembly//oxidation-reduction process GO:0051536//GO:0045735//GO:0010309//GO:0005506//GO:0005515 iron-sulfur cluster binding//nutrient reservoir activity//acireductone dioxygenase [iron(II)-requiring] activity//iron ion binding//protein binding -- -- -- -- Cluster-8309.30872 BF_2 200.68 8.66 1257 642933598 XP_008197488.1 929 1.5e-97 PREDICTED: NFU1 iron-sulfur cluster scaffold homolog, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4IMF6 780 1.2e-81 NFU1 iron-sulfur cluster scaffold homolog, mitochondrial OS=Drosophila sechellia GN=GM13534 PE=3 SV=1 PF01106 NifU-like domain GO:0016226 iron-sulfur cluster assembly GO:0051536//GO:0005506 iron-sulfur cluster binding//iron ion binding -- -- KOG2358 NifU-like domain-containing proteins Cluster-8309.30873 BF_2 152.00 65.04 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15178 Mitochondrial import receptor subunit TOM5 homolog -- -- -- -- GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.30876 BF_2 406.99 31.95 820 546681029 ERL91194.1 353 6.2e-31 hypothetical protein D910_08533 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P26352 128 3.1e-06 Thymosin beta-12 OS=Oncorhynchus mykiss PE=1 SV=2 PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- KOG4794 Thymosin beta Cluster-8309.30878 BF_2 27.97 1.76 951 642932789 XP_008196985.1 513 2.0e-49 PREDICTED: fibroblast growth factor 1-like [Tribolium castaneum]>gi|270012810|gb|EFA09258.1| fibroblast growth factor 1 [Tribolium castaneum] -- -- -- -- -- K18496 FGF1 fibroblast growth factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18496 P61148 227 1.2e-17 Fibroblast growth factor 1 OS=Mus musculus GN=Fgf1 PE=2 SV=1 PF06268//PF00167 Fascin domain//Fibroblast growth factor GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083//GO:0051015//GO:0030674 growth factor activity//actin filament binding//protein binding, bridging -- -- -- -- Cluster-8309.30880 BF_2 755.73 21.75 1741 189234116 XP_968417.2 1151 3.9e-123 PREDICTED: uridine phosphorylase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 626 1.2e-63 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3728 Uridine phosphorylase Cluster-8309.30881 BF_2 11.00 0.58 1084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30884 BF_2 301.79 2.33 5700 642936624 XP_008198511.1 2726 3.0e-305 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.08822e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.8e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF01166//PF02346 TSC-22/dip/bun family//Chordopoxvirus multifunctional envelope protein A27 GO:0006355//GO:0019064 regulation of transcription, DNA-templated//fusion of virus membrane with host plasma membrane GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.30885 BF_2 48.90 1.28 1882 642927984 XP_008195472.1 735 7.2e-75 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30886 BF_2 490.60 13.44 1814 642927984 XP_008195472.1 735 7.0e-75 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30887 BF_2 10.35 0.81 820 642930121 XP_008196261.1 257 8.4e-20 PREDICTED: acylphosphatase-1-like [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 P56544 204 4.8e-15 Acylphosphatase-1 OS=Drosophila melanogaster GN=Acyp PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30888 BF_2 1347.28 13.40 4494 91088575 XP_973165.1 4337 0.0e+00 PREDICTED: ubiquitin conjugation factor E4 B [Tribolium castaneum]>gi|270011701|gb|EFA08149.1| hypothetical protein TcasGA2_TC005767 [Tribolium castaneum] -- -- -- -- -- K10597 UBE4B, UFD2 ubiquitin conjugation factor E4 B http://www.genome.jp/dbget-bin/www_bget?ko:K10597 Q9ES00 2276 1.5e-254 Ubiquitin conjugation factor E4 B OS=Mus musculus GN=Ube4b PE=1 SV=3 PF04564//PF10408 U-box domain//Ubiquitin elongating factor core GO:0006511//GO:0016567 ubiquitin-dependent protein catabolic process//protein ubiquitination GO:0004842//GO:0034450 ubiquitin-protein transferase activity//ubiquitin-ubiquitin ligase activity GO:0000151 ubiquitin ligase complex KOG2042 Ubiquitin fusion degradation protein-2 Cluster-8309.30890 BF_2 688.47 5.49 5537 642937775 XP_008198940.1 5800 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X2 [Tribolium castaneum] 665815760 XM_008558331.1 166 1.32625e-78 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 3294 0.0e+00 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0206 P-type ATPase Cluster-8309.30891 BF_2 4.00 1.32 413 157129974 XP_001655497.1 154 3.7e-08 AAEL000375-PA [Aedes aegypti]>gi|108884380|gb|EAT48605.1| AAEL000375-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- P0DM55 124 4.6e-06 Venom peptide SjAPI OS=Scorpiops jendeki PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30893 BF_2 45.28 1.10 2004 91095219 XP_969883.1 641 6.1e-64 PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940081|ref|XP_008192927.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940083|ref|XP_008192931.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|270016019|gb|EFA12467.1| hypothetical protein TcasGA2_TC010611 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q765P3 488 1.4e-47 Peptidoglycan-recognition protein 2 OS=Holotrichia diomphalia GN=PGRP-2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30894 BF_2 144.08 3.12 2217 91086813 XP_973672.1 221 3.4e-15 PREDICTED: neutral and basic amino acid transport protein rBAT [Tribolium castaneum]>gi|270010450|gb|EFA06898.1| hypothetical protein TcasGA2_TC009845 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30895 BF_2 860.93 7.37 5174 642928927 XP_008195620.1 2199 3.5e-244 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 282 4.0638e-143 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 559 2.1e-55 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30897 BF_2 86.21 0.92 4202 642932106 XP_008196856.1 1545 1.9e-168 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X5 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.38468e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 5.4e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF01213//PF07525//PF00622 Adenylate cyclase associated (CAP) N terminal//SOCS box//SPRY domain GO:0035556//GO:0007010 intracellular signal transduction//cytoskeleton organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.30899 BF_2 6.14 0.61 708 270016290 EFA12736.1 180 6.2e-11 hypothetical protein TcasGA2_TC002373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30900 BF_2 600.74 6.37 4235 158299912 XP_319921.4 2480 7.4e-277 AGAP009160-PA [Anopheles gambiae str. PEST]>gi|157013746|gb|EAA14733.4| AGAP009160-PA [Anopheles gambiae str. PEST] 701339117 XM_009982980.1 98 6.40207e-41 PREDICTED: Tauraco erythrolophus arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like (LOC104376406), partial mRNA K12491 AGAP1_3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12491 Q9NGC3 1460 5.7e-160 Centaurin-gamma-1A OS=Drosophila melanogaster GN=CenG1A PE=2 SV=2 PF00071//PF01412//PF13606//PF08477//PF00023 Ras family//Putative GTPase activating protein for Arf//Ankyrin repeat//Ras of Complex, Roc, domain of DAPkinase//Ankyrin repeat GO:0007264//GO:0050794 small GTPase mediated signal transduction//regulation of cellular process GO:0005515//GO:0005488//GO:0005525//GO:0005096 protein binding//binding//GTP binding//GTPase activator activity -- -- KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains) Cluster-8309.30901 BF_2 28.00 4.13 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30903 BF_2 24.54 0.37 3072 642937652 XP_966876.3 559 3.0e-54 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N4W9 383 3.2e-35 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF00096//PF13465//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.30907 BF_2 274.00 5.47 2381 478256547 ENN76731.1 2406 1.6e-268 hypothetical protein YQE_06796, partial [Dendroctonus ponderosae] -- -- -- -- -- K11438 PRMT7 protein arginine N-methyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11438 Q16NS8 1542 1.0e-169 Protein arginine N-methyltransferase 7 OS=Aedes aegypti GN=Art7 PE=3 SV=1 PF08241//PF02390//PF00965//PF05175//PF03602 Methyltransferase domain//Putative methyltransferase//Tissue inhibitor of metalloproteinase//Methyltransferase small domain//Conserved hypothetical protein 95 GO:0008152//GO:0031167//GO:0009451//GO:0008033//GO:0006400 metabolic process//rRNA methylation//RNA modification//tRNA processing//tRNA modification GO:0008191//GO:0008176//GO:0008168 metalloendopeptidase inhibitor activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.3091 BF_2 4.00 0.92 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30910 BF_2 50.06 0.36 6045 91078794 XP_970038.1 3616 0.0e+00 PREDICTED: WD repeat-containing protein 3 [Tribolium castaneum]>gi|270003730|gb|EFA00178.1| hypothetical protein TcasGA2_TC003001 [Tribolium castaneum] 642916054 XM_008192652.1 69 1.21057e-24 PREDICTED: Tribolium castaneum uncharacterized LOC100141824 (LOC100141824), transcript variant X3, mRNA K14556 DIP2, UTP12, WDR3 U3 small nucleolar RNA-associated protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14556 Q9UNX4 2070 1.5e-230 WD repeat-containing protein 3 OS=Homo sapiens GN=WDR3 PE=1 SV=1 PF00400//PF04494 WD domain, G-beta repeat//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.30911 BF_2 2.00 0.99 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30912 BF_2 61.18 0.46 5833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.30913 BF_2 13.00 0.62 1169 270016897 EFA13343.1 199 6.4e-13 hypothetical protein TcasGA2_TC005298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- -- -- Cluster-8309.30916 BF_2 1237.36 7.65 7057 642935775 XP_008198168.1 1750 5.5e-192 PREDICTED: integrin alpha-PS3-like [Tribolium castaneum] -- -- -- -- -- K17595 SPATA2 spermatogenesis-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17595 O44386 660 5.5e-67 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 PF00641//PF08516 Zn-finger in Ran binding protein and others//ADAM cysteine-rich GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.30917 BF_2 380.00 68.24 520 642919151 XP_008191758.1 268 2.8e-21 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95209 122 9.9e-06 Sortilin-related receptor OS=Oryctolagus cuniculus GN=SORL1 PE=2 SV=1 PF00866 Ring hydroxylating beta subunit GO:0055114//GO:0006725 oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.30918 BF_2 1531.61 8.23 8070 768420852 XP_011551210.1 1115 2.7e-118 PREDICTED: E3 ubiquitin-protein ligase SIAH1-like [Plutella xylostella] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q920M9 1094 3.0e-117 E3 ubiquitin-protein ligase SIAH1 OS=Rattus norvegicus GN=Siah1 PE=1 SV=2 PF00198//PF05191//PF00097//PF03145//PF02817 2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Adenylate kinase, active site lid//Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//e3 binding domain GO:0006511//GO:0008152//GO:0007275//GO:0006144//GO:0046034 ubiquitin-dependent protein catabolic process//metabolic process//multicellular organismal development//purine nucleobase metabolic process//ATP metabolic process GO:0004017//GO:0046872//GO:0016746 adenylate kinase activity//metal ion binding//transferase activity, transferring acyl groups GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.30919 BF_2 128.31 1.55 3747 642932076 XP_008196848.1 834 4.8e-86 PREDICTED: pre-mRNA-splicing regulator female-lethal(2)D [Tribolium castaneum]>gi|270011667|gb|EFA08115.1| hypothetical protein TcasGA2_TC005719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28XY0 591 3.0e-59 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila pseudoobscura pseudoobscura GN=fl(2)d PE=3 SV=2 PF04799//PF09177//PF04977//PF06156//PF05791//PF17098//PF06005//PF11744//PF01496 fzo-like conserved region//Syntaxin 6, N-terminal//Septum formation initiator//Protein of unknown function (DUF972)//Bacillus haemolytic enterotoxin (HBL)//Pre-mRNA-splicing regulator WTAP//Protein of unknown function (DUF904)//Aluminium activated malate transporter//V-type ATPase 116kDa subunit family GO:0048024//GO:0008053//GO:0043093//GO:0000917//GO:0048193//GO:0015991//GO:0015743//GO:0006260//GO:0015992//GO:0007049//GO:0009405 regulation of mRNA splicing, via spliceosome//mitochondrial fusion//FtsZ-dependent cytokinesis//barrier septum assembly//Golgi vesicle transport//ATP hydrolysis coupled proton transport//malate transport//DNA replication//proton transport//cell cycle//pathogenesis GO:0015078//GO:0003924 hydrogen ion transmembrane transporter activity//GTPase activity GO:0016020//GO:0005741//GO:0033179//GO:0005634//GO:0005737//GO:0016021 membrane//mitochondrial outer membrane//proton-transporting V-type ATPase, V0 domain//nucleus//cytoplasm//integral component of membrane KOG2991 Splicing regulator Cluster-8309.30920 BF_2 1.00 0.94 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30921 BF_2 126.06 1.41 4018 642932892 XP_008197175.1 730 5.9e-74 PREDICTED: uncharacterized protein LOC103314074 [Tribolium castaneum]>gi|270011476|gb|EFA07924.1| hypothetical protein TcasGA2_TC005502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30922 BF_2 128.00 107.49 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30924 BF_2 223.79 16.54 853 642913424 XP_008201005.1 193 2.3e-12 PREDICTED: calcium-binding mitochondrial carrier protein Aralar1 [Tribolium castaneum] -- -- -- -- -- K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q21153 156 1.8e-09 Probable calcium-binding mitochondrial carrier K02F3.2 OS=Caenorhabditis elegans GN=K02F3.2 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.30929 BF_2 174.67 7.39 1276 91081235 XP_975638.1 1065 2.7e-113 PREDICTED: ubiquitin thioesterase otubain-like [Tribolium castaneum]>gi|270006065|gb|EFA02513.1| hypothetical protein TcasGA2_TC008217 [Tribolium castaneum] -- -- -- -- -- K09602 OTUB1 ubiquitin thioesterase protein OTUB1 http://www.genome.jp/dbget-bin/www_bget?ko:K09602 Q9VL00 739 6.9e-77 Ubiquitin thioesterase otubain-like OS=Drosophila melanogaster GN=CG4968 PE=2 SV=1 -- -- GO:0019538 protein metabolic process GO:0008242 omega peptidase activity -- -- KOG3991 Uncharacterized conserved protein Cluster-8309.30931 BF_2 11.12 1.58 582 270002107 EEZ98554.1 153 6.9e-08 hypothetical protein TcasGA2_TC001061 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30932 BF_2 43.00 4.86 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30935 BF_2 20.53 0.31 3072 546684665 ERL94282.1 285 1.8e-22 hypothetical protein D910_11563 [Dendroctonus ponderosae] -- -- -- -- -- K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 A4QNI8 198 9.0e-14 ELAV-like protein 4 OS=Xenopus tropicalis GN=elavl4 PE=2 SV=1 PF00076//PF01534 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Frizzled/Smoothened family membrane region GO:0007166 cell surface receptor signaling pathway GO:0003676 nucleic acid binding GO:0016020 membrane KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.30937 BF_2 578.55 30.26 1087 91080235 XP_972829.1 191 5.0e-12 PREDICTED: caprin homolog [Tribolium castaneum]>gi|270005626|gb|EFA02074.1| hypothetical protein TcasGA2_TC007709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0006865//GO:0003333 amino acid transport//amino acid transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30938 BF_2 1136.00 11.85 4296 237681147 NP_001153720.1 2487 1.2e-277 semaphorin-1a [Tribolium castaneum]>gi|270015157|gb|EFA11605.1| semaphorin-1a-like protein [Tribolium castaneum] -- -- -- -- -- K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q26972 2358 4.3e-264 Semaphorin-1A OS=Tribolium confusum GN=SEMA-1A PE=2 SV=1 PF01403//PF01437 Sema domain//Plexin repeat GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0005515//GO:0004872 protein binding//receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG3611 Semaphorins Cluster-8309.30939 BF_2 72.07 2.03 1771 642936923 XP_970894.2 1001 9.7e-106 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 264 1.2e-21 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF03776//PF13606//PF00023//PF09494 Septum formation topological specificity factor MinE//Ankyrin repeat//Ankyrin repeat//Slx4 endonuclease GO:0051301//GO:0006260//GO:0032955//GO:0006308//GO:0006281 cell division//DNA replication//regulation of barrier septum assembly//DNA catabolic process//DNA repair GO:0005515//GO:0017108 protein binding//5'-flap endonuclease activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus -- -- Cluster-8309.30941 BF_2 1292.68 11.27 5086 91089275 XP_970398.1 2665 3.1e-298 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X1 [Tribolium castaneum] 642933027 XM_965305.2 493 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2186 4.5e-244 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.30942 BF_2 545.28 12.37 2131 189237581 XP_974946.2 1234 1.1e-132 PREDICTED: glypican-6 [Tribolium castaneum] -- -- -- -- -- K08110 GPC4 glypican 4 (K-glypican) http://www.genome.jp/dbget-bin/www_bget?ko:K08110 Q5RE54 675 3.0e-69 Glypican-6 OS=Pongo abelii GN=GPC6 PE=2 SV=1 PF12906//PF01153//PF02404 RING-variant domain//Glypican//Stem cell factor GO:0007165//GO:0007155 signal transduction//cell adhesion GO:0005173//GO:0008270//GO:0043395 stem cell factor receptor binding//zinc ion binding//heparan sulfate proteoglycan binding GO:0016020//GO:0005578 membrane//proteinaceous extracellular matrix KOG3821 Heparin sulfate cell surface proteoglycan Cluster-8309.30943 BF_2 80.29 1.56 2437 642918231 XP_008191422.1 1667 7.9e-183 PREDICTED: uncharacterized protein LOC100141757 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30944 BF_2 471.49 20.44 1252 189235871 XP_001811450.1 819 8.7e-85 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30946 BF_2 3.00 5.74 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30947 BF_2 321.88 2.18 6460 270014138 EFA10586.1 5229 0.0e+00 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936567 XM_008200267.1 595 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X1, mRNA -- -- -- -- Q07553 1915 1.5e-212 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00069//PF00211//PF07714//PF00558//PF07701 Protein kinase domain//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Vpu protein//Heme NO binding associated GO:0006812//GO:0032801//GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0019076//GO:0006144//GO:0006468 cation transport//receptor catabolic process//cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//viral release from host cell//purine nucleobase metabolic process//protein phosphorylation GO:0004383//GO:0016849//GO:0004672//GO:0005524//GO:0005261 guanylate cyclase activity//phosphorus-oxygen lyase activity//protein kinase activity//ATP binding//cation channel activity GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30948 BF_2 555.84 2.61 9198 270014138 EFA10586.1 4698 0.0e+00 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936567 XM_008200267.1 579 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X1, mRNA -- -- -- -- Q07553 1915 2.2e-212 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF15427//PF01073//PF07701//PF00558//PF07714//PF00211//PF02866//PF00069//PF00056 S100P-binding protein//3-beta hydroxysteroid dehydrogenase/isomerase family//Heme NO binding associated//Vpu protein//Protein tyrosine kinase//Adenylate and Guanylate cyclase catalytic domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Protein kinase domain//lactate/malate dehydrogenase, NAD binding domain GO:0006182//GO:0008210//GO:0006144//GO:0019076//GO:0032801//GO:0046039//GO:0006468//GO:0006812//GO:0008207//GO:0035556//GO:0006694//GO:0055114//GO:0008209//GO:0009190 cGMP biosynthetic process//estrogen metabolic process//purine nucleobase metabolic process//viral release from host cell//receptor catabolic process//GTP metabolic process//protein phosphorylation//cation transport//C21-steroid hormone metabolic process//intracellular signal transduction//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//cyclic nucleotide biosynthetic process GO:0016491//GO:0004672//GO:0016849//GO:0003854//GO:0005524//GO:0005261//GO:0016616//GO:0004383//GO:0048306 oxidoreductase activity//protein kinase activity//phosphorus-oxygen lyase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//cation channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//guanylate cyclase activity//calcium-dependent protein binding GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30949 BF_2 475.69 3.89 5398 270014138 EFA10586.1 2956 0.0e+00 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936569 XM_008200268.1 293 3.25536e-149 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X2, mRNA -- -- -- -- Q07553 1001 1.2e-106 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00558//PF07701//PF00211//PF07714//PF00069 Vpu protein//Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase//Protein kinase domain GO:0006182//GO:0046039//GO:0019076//GO:0006144//GO:0006468//GO:0006812//GO:0035556//GO:0032801//GO:0009190 cGMP biosynthetic process//GTP metabolic process//viral release from host cell//purine nucleobase metabolic process//protein phosphorylation//cation transport//intracellular signal transduction//receptor catabolic process//cyclic nucleotide biosynthetic process GO:0005524//GO:0005261//GO:0004383//GO:0004672//GO:0016849 ATP binding//cation channel activity//guanylate cyclase activity//protein kinase activity//phosphorus-oxygen lyase activity GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.30953 BF_2 3.63 0.31 776 91077456 XP_967801.1 471 1.2e-44 PREDICTED: sine oculis-binding protein homolog [Tribolium castaneum]>gi|270002754|gb|EEZ99201.1| sine oculis-binding protein [Tribolium castaneum] 768434667 XM_011560449.1 63 3.23776e-22 PREDICTED: Plutella xylostella sine oculis-binding protein homolog (LOC105389350), partial mRNA -- -- -- -- Q0P5V2 130 1.7e-06 Sine oculis-binding protein homolog OS=Mus musculus GN=Sobp PE=2 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.30954 BF_2 422.97 7.41 2676 662209763 XP_008478495.1 561 1.5e-54 PREDICTED: uncharacterized protein LOC103515333 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.30962 BF_2 1366.05 6.15 9580 546684972 ERL94546.1 4054 0.0e+00 hypothetical protein D910_11823 [Dendroctonus ponderosae] 768442001 XM_011564452.1 512 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q9Z1N3 1894 6.1e-210 Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1 PF00437//PF00130//PF15177//PF00612//PF12678//PF00628//PF07649//PF00063//PF00788//PF02954//PF09280//PF00620 Type II/IV secretion system protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Interleukin-28A//IQ calmodulin-binding motif//RING-H2 zinc finger//PHD-finger//C1-like domain//Myosin head (motor domain)//Ras association (RalGDS/AF-6) domain//Bacterial regulatory protein, Fis family//XPC-binding domain//RhoGAP domain GO:0006281//GO:0006810//GO:0007165//GO:0055114//GO:0035556//GO:0051607//GO:0050778//GO:0007259//GO:0043161//GO:0006289 DNA repair//transport//signal transduction//oxidation-reduction process//intracellular signal transduction//defense response to virus//positive regulation of immune response//JAK-STAT cascade//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair GO:0005524//GO:0047134//GO:0005125//GO:0043565//GO:0008270//GO:0005515//GO:0003684//GO:0003774 ATP binding//protein-disulfide reductase activity//cytokine activity//sequence-specific DNA binding//zinc ion binding//protein binding//damaged DNA binding//motor activity GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.30963 BF_2 64.00 1.51 2059 332373882 AEE62082.1 167 5.8e-09 unknown [Dendroctonus ponderosae]>gi|478268586|gb|ENN83219.1| hypothetical protein YQE_00422, partial [Dendroctonus ponderosae]>gi|478268588|gb|ENN83220.1| hypothetical protein YQE_00421, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30964 BF_2 3.00 0.51 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30966 BF_2 222.21 1.50 6471 642922445 XP_008193172.1 5199 0.0e+00 PREDICTED: uncharacterized protein LOC655273 [Tribolium castaneum] 665794170 XM_008546548.1 48 6.11458e-13 PREDICTED: Microplitis demolitor adenylate cyclase type 8 (LOC103569316), transcript variant X1, mRNA K08048 ADCY8 adenylate cyclase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08048 P40145 1239 3.7e-134 Adenylate cyclase type 8 OS=Homo sapiens GN=ADCY8 PE=1 SV=1 PF06327//PF07701//PF00211 Domain of Unknown Function (DUF1053)//Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain GO:0046039//GO:0006182//GO:0006144//GO:0006171//GO:0009190//GO:0035556 GTP metabolic process//cGMP biosynthetic process//purine nucleobase metabolic process//cAMP biosynthetic process//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0004383//GO:0004016//GO:0016849 guanylate cyclase activity//adenylate cyclase activity//phosphorus-oxygen lyase activity GO:0005886 plasma membrane -- -- Cluster-8309.30970 BF_2 101.01 0.91 4908 91086115 XP_968072.1 1323 1.2e-142 PREDICTED: sister chromatid cohesion protein DCC1 [Tribolium castaneum] -- -- -- -- -- K11271 DSCC1, DCC1 sister chromatid cohesion protein DCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K11271 Q6GMB0 633 5.2e-64 Sister chromatid cohesion protein DCC1 OS=Xenopus laevis GN=dscc1 PE=2 SV=1 PF00018//PF14604//PF04088//PF04421 SH3 domain//Variant SH3 domain//Peroxin 13, N-terminal region//Mss4 protein GO:0007264//GO:0016560//GO:0043087 small GTPase mediated signal transduction//protein import into peroxisome matrix, docking//regulation of GTPase activity GO:0005515//GO:0005085 protein binding//guanyl-nucleotide exchange factor activity GO:0005777//GO:0016021 peroxisome//integral component of membrane KOG3875 Peroxisomal biogenesis protein peroxin Cluster-8309.30973 BF_2 98.14 2.16 2191 546684096 ERL93815.1 355 9.7e-31 hypothetical protein D910_11101 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P49096 197 8.4e-14 Cytochrome b5 OS=Musca domestica GN=Cyt-b5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0537 Cytochrome b5 Cluster-8309.30975 BF_2 298.83 11.56 1369 642913555 XP_008201060.1 1209 5.7e-130 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X1 [Tribolium castaneum] 642913554 XM_008202838.1 344 3.61261e-178 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X1, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 649 2.0e-66 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF03222//PF00324//PF04544//PF13520 Tryptophan/tyrosine permease family//Amino acid permease//Herpesvirus egress protein UL20//Amino acid permease GO:0003333//GO:0055085//GO:0006865//GO:0006810//GO:0019058 amino acid transmembrane transport//transmembrane transport//amino acid transport//transport//viral life cycle GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.30976 BF_2 124.98 6.17 1135 642936307 XP_008198389.1 509 7.0e-49 PREDICTED: protein FAM107B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI00 145 4.6e-08 Protein FAM107B OS=Bos taurus GN=FAM107B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.30977 BF_2 483.82 4.66 4627 189241000 XP_968712.2 3471 0.0e+00 PREDICTED: protein Skeletor, isoforms B/C isoform X1 [Tribolium castaneum]>gi|557470278|gb|AHA05989.1| knickkopf 3 [Tribolium castaneum] 642935031 XM_008201691.1 245 1.34348e-122 PREDICTED: Tribolium castaneum knickkopf 3 (LOC657143), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 2281 3.9e-255 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.30978 BF_2 27.00 3.17 643 642928696 XP_008199742.1 450 2.8e-42 PREDICTED: uncharacterized protein LOC662585 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30979 BF_2 4.00 0.41 692 557745700 AHA33380.1 732 5.9e-75 odorant-binding protein 2 [Batocera horsfieldi] 557745699 KC461116.1 405 0 Batocera horsfieldi odorant-binding protein 2 (obp2) mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.30980 BF_2 237.17 2.94 3667 765527265 AJS10721.1 581 1.0e-56 14-3-3 epsilon [Tenebrio molitor] 346713643 AK386529.1 218 1.08535e-107 Bombyx mori mRNA, clone: fprW12H08 K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 P62262 573 3.5e-57 14-3-3 protein epsilon OS=Ovis aries GN=YWHAE PE=1 SV=1 PF00060//PF08038 Ligand-gated ion channel//TOM7 family GO:0006811//GO:0030150//GO:0007268//GO:0007165 ion transport//protein import into mitochondrial matrix//synaptic transmission//signal transduction GO:0004970 ionotropic glutamate receptor activity GO:0005742//GO:0016020 mitochondrial outer membrane translocase complex//membrane KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.30984 BF_2 132.44 2.61 2406 478263070 ENN81470.1 1555 7.6e-170 hypothetical protein YQE_02162, partial [Dendroctonus ponderosae]>gi|546686023|gb|ERL95423.1| hypothetical protein D910_12687 [Dendroctonus ponderosae] 620970074 XM_001518444.3 46 2.91664e-12 PREDICTED: Ornithorhynchus anatinus carbohydrate sulfotransferase 13-like (LOC100088952), partial mRNA K01017 CHST11 chondroitin 4-sulfotransferase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K01017 Q7T3S3 541 1.2e-53 Carbohydrate sulfotransferase 11 OS=Danio rerio GN=chst11 PE=2 SV=1 PF00240//PF03567 Ubiquitin family//Sulfotransferase family -- -- GO:0005515//GO:0008146 protein binding//sulfotransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.30986 BF_2 382.56 7.95 2299 478263070 ENN81470.1 1555 7.3e-170 hypothetical protein YQE_02162, partial [Dendroctonus ponderosae]>gi|546686023|gb|ERL95423.1| hypothetical protein D910_12687 [Dendroctonus ponderosae] 620970074 XM_001518444.3 46 2.78502e-12 PREDICTED: Ornithorhynchus anatinus carbohydrate sulfotransferase 13-like (LOC100088952), partial mRNA K01017 CHST11 chondroitin 4-sulfotransferase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K01017 Q7T3S3 541 1.1e-53 Carbohydrate sulfotransferase 11 OS=Danio rerio GN=chst11 PE=2 SV=1 PF03567//PF00240 Sulfotransferase family//Ubiquitin family -- -- GO:0008146//GO:0005515 sulfotransferase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.30987 BF_2 52.43 1.21 2101 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03851 UV-endonuclease UvdE GO:0006289//GO:0009411 nucleotide-excision repair//response to UV GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.30988 BF_2 33.65 0.80 2056 91082695 XP_971685.1 967 9.9e-102 PREDICTED: protein disulfide-isomerase A3 [Tribolium castaneum]>gi|270014973|gb|EFA11421.1| hypothetical protein TcasGA2_TC013598 [Tribolium castaneum] 354548260 HE605209.1 38 6.96135e-08 Candida parapsilosis strain CDC317 annotated contig 006110 K08056 PDIA3, GRP58 protein disulfide isomerase family A, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08056 Q8JG64 501 4.4e-49 Protein disulfide-isomerase A3 OS=Gallus gallus GN=PDIA3 PE=2 SV=1 PF00085//PF00578 Thioredoxin//AhpC/TSA family GO:0006662//GO:0006118//GO:0045454//GO:0055114 glycerol ether metabolic process//obsolete electron transport//cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0016853//GO:0015035//GO:0016209//GO:0009055 oxidoreductase activity//isomerase activity//protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity GO:0005783 endoplasmic reticulum KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.30989 BF_2 5553.35 105.03 2499 91082695 XP_971685.1 2147 1.8e-238 PREDICTED: protein disulfide-isomerase A3 [Tribolium castaneum]>gi|270014973|gb|EFA11421.1| hypothetical protein TcasGA2_TC013598 [Tribolium castaneum] 354548260 HE605209.1 38 8.48727e-08 Candida parapsilosis strain CDC317 annotated contig 006110 K08056 PDIA3, GRP58 protein disulfide isomerase family A, member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08056 Q8JG64 1232 9.2e-134 Protein disulfide-isomerase A3 OS=Gallus gallus GN=PDIA3 PE=2 SV=1 PF08534//PF00085//PF00462//PF00578 Redoxin//Thioredoxin//Glutaredoxin//AhpC/TSA family GO:0006118//GO:0055114//GO:0045454//GO:0006662 obsolete electron transport//oxidation-reduction process//cell redox homeostasis//glycerol ether metabolic process GO:0009055//GO:0016209//GO:0015035//GO:0016853//GO:0016491 electron carrier activity//antioxidant activity//protein disulfide oxidoreductase activity//isomerase activity//oxidoreductase activity GO:0005783 endoplasmic reticulum KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.30990 BF_2 192.71 2.05 4214 478255672 ENN75884.1 2568 4.6e-287 hypothetical protein YQE_07613, partial [Dendroctonus ponderosae]>gi|546678103|gb|ERL88812.1| hypothetical protein D910_06194 [Dendroctonus ponderosae]>gi|546687720|gb|ERL96280.1| hypothetical protein D910_01703 [Dendroctonus ponderosae] -- -- -- -- -- K06515 SLC44A1, CDW92 solute carrier family 44 (choline transporter-like protein), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06515 Q9VZE7 1555 5.5e-171 CTL-like protein 1 OS=Drosophila melanogaster GN=CG1311 PE=2 SV=1 PF02112 cAMP phosphodiesterases class-II GO:0006198 cAMP catabolic process GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity -- -- KOG1362 Choline transporter-like protein Cluster-8309.30991 BF_2 682.29 5.93 5103 478255672 ENN75884.1 2568 5.5e-287 hypothetical protein YQE_07613, partial [Dendroctonus ponderosae]>gi|546678103|gb|ERL88812.1| hypothetical protein D910_06194 [Dendroctonus ponderosae]>gi|546687720|gb|ERL96280.1| hypothetical protein D910_01703 [Dendroctonus ponderosae] -- -- -- -- -- K06515 SLC44A1, CDW92 solute carrier family 44 (choline transporter-like protein), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06515 Q9VZE7 1555 6.6e-171 CTL-like protein 1 OS=Drosophila melanogaster GN=CG1311 PE=2 SV=1 PF02112 cAMP phosphodiesterases class-II GO:0006198 cAMP catabolic process GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity -- -- KOG2971 RNA-binding protein required for biogenesis of the ribosomal 60S subunit Cluster-8309.30993 BF_2 141.80 0.96 6438 642929205 XP_008195735.1 3696 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 554 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 1822 9.2e-202 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF00784//PF00400//PF01506//PF07569 MyTH4 domain//WD domain, G-beta repeat//Hepatitis C virus non-structural 5a protein membrane anchor//TUP1-like enhancer of split GO:0006355//GO:0006508//GO:0006144 regulation of transcription, DNA-templated//proteolysis//purine nucleobase metabolic process GO:0004197//GO:0017111//GO:0004252//GO:0003968//GO:0005515 cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//RNA-directed RNA polymerase activity//protein binding GO:0031379//GO:0005634//GO:0005856 RNA-directed RNA polymerase complex//nucleus//cytoskeleton KOG4155 FOG: WD40 repeat Cluster-8309.30994 BF_2 8.00 0.47 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.30996 BF_2 1131.74 18.96 2784 91089337 XP_972494.1 2610 4.1e-292 PREDICTED: protein singed [Tribolium castaneum]>gi|270012518|gb|EFA08966.1| hypothetical protein TcasGA2_TC006673 [Tribolium castaneum] 642933078 XM_967401.2 574 0 PREDICTED: Tribolium castaneum protein singed (LOC661226), mRNA K17455 FSCN1_2 fascin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17455 Q24524 1954 2.0e-217 Protein singed OS=Drosophila melanogaster GN=sn PE=3 SV=1 PF00167//PF06268//PF01529//PF01786 Fibroblast growth factor//Fascin domain//DHHC palmitoyltransferase//Alternative oxidase GO:0040007//GO:0007165//GO:0008283//GO:0006118//GO:0055114 growth//signal transduction//cell proliferation//obsolete electron transport//oxidation-reduction process GO:0008083//GO:0009916//GO:0051015//GO:0008270//GO:0030674 growth factor activity//alternative oxidase activity//actin filament binding//zinc ion binding//protein binding, bridging -- -- -- -- Cluster-8309.30997 BF_2 5.25 0.64 630 478255100 ENN75330.1 460 1.9e-43 hypothetical protein YQE_08107, partial [Dendroctonus ponderosae] -- -- -- -- -- K01890 FARSB, pheT phenylalanyl-tRNA synthetase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01890 Q9VCA5 399 9.1e-38 Phenylalanine--tRNA ligase beta subunit OS=Drosophila melanogaster GN=beta-PheRS PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2472 Phenylalanyl-tRNA synthetase beta subunit Cluster-8309.30999 BF_2 516.19 5.65 4112 546676782 ERL87728.1 270 1.3e-20 hypothetical protein D910_05118 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31 BF_2 12.00 0.37 1628 831314739 XP_012689951.1 272 3.0e-21 PREDICTED: protein-tyrosine kinase 6-like [Clupea harengus] -- -- -- -- -- -- -- -- -- O08680 258 5.3e-21 Ephrin type-A receptor 3 OS=Rattus norvegicus GN=Epha3 PE=2 SV=1 PF07714//PF00069//PF01007 Protein tyrosine kinase//Protein kinase domain//Inward rectifier potassium channel GO:0006468//GO:0006813 protein phosphorylation//potassium ion transport GO:0005524//GO:0005242//GO:0004672 ATP binding//inward rectifier potassium channel activity//protein kinase activity GO:0016021//GO:0008076 integral component of membrane//voltage-gated potassium channel complex -- -- Cluster-8309.31000 BF_2 111.96 3.32 1699 91087061 XP_974794.1 923 1.0e-96 PREDICTED: retrograde Golgi transport protein RGP1 homolog [Tribolium castaneum]>gi|270010531|gb|EFA06979.1| hypothetical protein TcasGA2_TC009939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9P3 346 3.4e-31 RAB6A-GEF complex partner protein 2 OS=Bos taurus GN=RGP1 PE=2 SV=1 PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm -- -- Cluster-8309.31001 BF_2 46.00 1.23 1855 642910336 XP_008200288.1 2075 3.0e-230 PREDICTED: equilibrative nucleoside transporter 4 [Tribolium castaneum]>gi|270014915|gb|EFA11363.1| hypothetical protein TcasGA2_TC011520 [Tribolium castaneum] -- -- -- -- -- K03323 SLC29A4, ENT4 solute carrier family 29 (equilibrative nucleoside transporter), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03323 A1L272 877 1.0e-92 Equilibrative nucleoside transporter 4 OS=Danio rerio GN=slc29a4 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.31002 BF_2 3435.68 44.73 3500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00977 Histidine biosynthesis protein GO:0000105 histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.31004 BF_2 3188.66 21.41 6516 642932520 XP_008197148.1 1026 4.5e-108 PREDICTED: LOW QUALITY PROTEIN: dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00627 DLAT, aceF, pdhC pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00627 P08461 786 1.3e-81 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial OS=Rattus norvegicus GN=Dlat PE=1 SV=3 PF06314//PF00198//PF01588//PF02817 Acetoacetate decarboxylase (ADC)//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Putative tRNA binding domain//e3 binding domain GO:0008152 metabolic process GO:0000049//GO:0016829//GO:0016746 tRNA binding//lyase activity//transferase activity, transferring acyl groups -- -- KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.31005 BF_2 1.00 2.01 285 641649148 XP_008184923.1 135 4.1e-06 PREDICTED: uncharacterized protein K02A2.6-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31006 BF_2 33.39 0.69 2324 26324131 AAN77377.1 2702 7.3e-303 smooth endoplasmic reticulum calcium ATPase [Porcellio scaber] 378947922 JN986572.1 801 0 Litopenaeus vannamei sarco/endoplasmic reticulum Ca2+-ATPase mRNA, complete cds K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2456 1.0e-275 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.31008 BF_2 134.31 0.65 8901 617652370 XP_007534385.1 565 1.8e-54 PREDICTED: zinc finger protein 14-like [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- Q03938 512 1.0e-49 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF16622//PF07776//PF13912//PF00230//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Major intrinsic protein//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006810 transport GO:0008270//GO:0046872//GO:0005215 zinc ion binding//metal ion binding//transporter activity GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.31009 BF_2 378.97 4.78 3603 189237997 XP_001812912.1 1051 3.2e-111 PREDICTED: dehydrogenase/reductase SDR family protein 7-like [Tribolium castaneum]>gi|270006651|gb|EFA03099.1| hypothetical protein TcasGA2_TC013008 [Tribolium castaneum] -- -- -- -- -- K11166 DHRS7B dehydrogenase/reductase SDR family member 7B http://www.genome.jp/dbget-bin/www_bget?ko:K11166 Q7Q732 796 4.8e-83 Dehydrogenase/reductase SDR family protein 7-like OS=Anopheles gambiae GN=AGAP005532 PE=3 SV=3 PF14972//PF01370//PF00106//PF02882//PF12242//PF02558 Mitochondrial morphogenesis regulator//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Ketopantoate reductase PanE/ApbA GO:0007005//GO:0055114//GO:0009396//GO:0046487//GO:0008152//GO:0015940 mitochondrion organization//oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process//pantothenate biosynthetic process GO:0008677//GO:0016491//GO:0004488//GO:0050662//GO:0003824 2-dehydropantoate 2-reductase activity//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//coenzyme binding//catalytic activity GO:0031305 integral component of mitochondrial inner membrane KOG1205 Predicted dehydrogenase Cluster-8309.31011 BF_2 67.54 1.07 2916 91092242 XP_971366.1 1543 2.3e-168 PREDICTED: protein ariadne-2 [Tribolium castaneum]>gi|270014427|gb|EFA10875.1| hypothetical protein TcasGA2_TC001697 [Tribolium castaneum] 462373241 APGK01024814.1 149 1.95805e-69 Dendroctonus ponderosae Seq01024824, whole genome shotgun sequence K11969 ARIH2 ariadne-2 http://www.genome.jp/dbget-bin/www_bget?ko:K11969 O76924 1271 3.2e-138 Protein ariadne-2 OS=Drosophila melanogaster GN=ari-2 PE=2 SV=1 PF00097//PF09749//PF14634//PF13639 Zinc finger, C3HC4 type (RING finger)//Uncharacterised conserved protein//zinc-RING finger domain//Ring finger domain GO:0034477 U6 snRNA 3'-end processing GO:0008270//GO:0004518//GO:0046872//GO:0005515 zinc ion binding//nuclease activity//metal ion binding//protein binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.31012 BF_2 759.62 5.06 6572 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 3.1e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF03193//PF00005//PF02367//PF13304//PF01926 SRP54-type protein, GTPase domain//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006614//GO:0002949//GO:0006200 SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification//obsolete ATP catabolic process GO:0016887//GO:0005525//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATP binding//GTPase activity -- -- -- -- Cluster-8309.31013 BF_2 60.44 0.39 6853 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 3.2e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF02367//PF01926//PF13304//PF03193//PF00005 SRP54-type protein, GTPase domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function, DUF258//ABC transporter GO:0002949//GO:0006614//GO:0006200 tRNA threonylcarbamoyladenosine modification//SRP-dependent cotranslational protein targeting to membrane//obsolete ATP catabolic process GO:0016887//GO:0005524//GO:0005525//GO:0003924 ATPase activity//ATP binding//GTP binding//GTPase activity -- -- -- -- Cluster-8309.31014 BF_2 560.79 3.79 6477 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 3.0e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF13304//PF02367//PF01926//PF03193//PF00005//PF00448 AAA domain, putative AbiEii toxin, Type IV TA system//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//Protein of unknown function, DUF258//ABC transporter//SRP54-type protein, GTPase domain GO:0006200//GO:0006614//GO:0002949 obsolete ATP catabolic process//SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005525//GO:0005524//GO:0016887 GTPase activity//GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.31015 BF_2 340.99 2.48 6032 642923453 XP_008193751.1 3987 0.0e+00 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1409 6.7e-154 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF00400//PF02460 WD domain, G-beta repeat//Patched family GO:0007165 signal transduction GO:0005515//GO:0008158 protein binding//hedgehog receptor activity GO:0016020 membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.31016 BF_2 1082.83 24.19 2160 478257576 ENN77730.1 2153 3.1e-239 hypothetical protein YQE_05801, partial [Dendroctonus ponderosae] -- -- -- -- -- K12261 HACL1 2-hydroxyacyl-CoA lyase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12261 Q8CHM7 1444 2.1e-158 2-hydroxyacyl-CoA lyase 1 OS=Rattus norvegicus GN=Hacl1 PE=1 SV=1 PF02776//PF02775//PF00205//PF02552 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Thiamine pyrophosphate enzyme, central domain//CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit GO:0019385 methanogenesis, from acetate GO:0030976//GO:0000287//GO:0003824 thiamine pyrophosphate binding//magnesium ion binding//catalytic activity -- -- KOG1185 Thiamine pyrophosphate-requiring enzyme Cluster-8309.31017 BF_2 49.74 0.37 5895 91082033 XP_970590.1 2741 5.6e-307 PREDICTED: tyrosine-protein phosphatase non-receptor type 23 [Tribolium castaneum]>gi|642921972|ref|XP_008192966.1| PREDICTED: tyrosine-protein phosphatase non-receptor type 23 [Tribolium castaneum] 801384853 XM_012200272.1 35 9.38654e-06 PREDICTED: Atta cephalotes tyrosine-protein phosphatase non-receptor type 23 (LOC105618741), mRNA K18040 PTPN23 tyrosine-protein phosphatase non-receptor type 23 http://www.genome.jp/dbget-bin/www_bget?ko:K18040 Q6PB44 1409 6.5e-154 Tyrosine-protein phosphatase non-receptor type 23 OS=Mus musculus GN=Ptpn23 PE=1 SV=2 PF00102//PF13949//PF00782 Protein-tyrosine phosphatase//ALIX V-shaped domain binding to HIV//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- KOG2220 Predicted signal transduction protein Cluster-8309.31020 BF_2 240.63 3.50 3161 642926739 XP_008194992.1 1564 9.0e-171 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X2 [Tribolium castaneum] 611988503 XM_007481079.1 71 4.86678e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 960 4.1e-102 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF13180//PF00595//PF00610 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3571 Dishevelled 3 and related proteins Cluster-8309.31021 BF_2 148.00 2.51 2753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31025 BF_2 57.91 1.63 1774 642938573 XP_969296.2 970 3.8e-102 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum]>gi|642938575|ref|XP_008199847.1| PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 720 1.5e-74 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.31026 BF_2 17.06 0.35 2352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31027 BF_2 4.00 0.63 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31028 BF_2 157.23 1.51 4637 817068525 XP_012256206.1 1118 6.9e-119 PREDICTED: matrix metalloproteinase-25-like [Athalia rosae] -- -- -- -- -- K07997 MMP17 matrix metalloproteinase-17 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07997 Q3U435 412 2.1e-38 Matrix metalloproteinase-25 OS=Mus musculus GN=Mmp25 PE=2 SV=1 PF10462//PF00413//PF01400 Peptidase M66//Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.31029 BF_2 29.00 0.53 2571 642917332 XP_008199257.1 1708 1.5e-187 PREDICTED: rac GTPase-activating protein 1 [Tribolium castaneum]>gi|642917334|ref|XP_008199258.1| PREDICTED: rac GTPase-activating protein 1 [Tribolium castaneum] -- -- -- -- -- K16733 RACGAP1, Tum Rac GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16733 Q9H0H5 913 9.3e-97 Rac GTPase-activating protein 1 OS=Homo sapiens GN=RACGAP1 PE=1 SV=1 PF00620//PF00130//PF15898 RhoGAP domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//cGMP-dependent protein kinase interacting domain GO:0035556//GO:0007165 intracellular signal transduction//signal transduction GO:0019901 protein kinase binding -- -- KOG3564 GTPase-activating protein Cluster-8309.31030 BF_2 45.53 0.66 3178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31033 BF_2 49.00 1.30 1862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31035 BF_2 545.00 12.48 2114 642922153 XP_008193036.1 996 4.4e-105 PREDICTED: afadin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31036 BF_2 124.41 1.50 3765 642922155 XP_008193037.1 3957 0.0e+00 PREDICTED: afadin isoform X2 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1341 3.2e-146 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF00595//PF00498//PF13180//PF16011 PDZ domain (Also known as DHR or GLGF)//FHA domain//PDZ domain//Carbohydrate-binding family 9 GO:0005975//GO:0016052 carbohydrate metabolic process//carbohydrate catabolic process GO:0005515//GO:0030246//GO:0004553 protein binding//carbohydrate binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.31037 BF_2 38.90 0.39 4468 642922153 XP_008193036.1 4275 0.0e+00 PREDICTED: afadin isoform X1 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1399 7.1e-153 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF13180//PF00595//PF00498//PF16011 PDZ domain//PDZ domain (Also known as DHR or GLGF)//FHA domain//Carbohydrate-binding family 9 GO:0016052//GO:0005975 carbohydrate catabolic process//carbohydrate metabolic process GO:0004553//GO:0030246//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding//protein binding -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.31038 BF_2 556.80 3.67 6638 642922153 XP_008193036.1 5647 0.0e+00 PREDICTED: afadin isoform X1 [Tribolium castaneum] 462316425 APGK01045079.1 64 8.001e-22 Dendroctonus ponderosae Seq01045089, whole genome shotgun sequence K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 P55196 2099 7.2e-234 Afadin OS=Homo sapiens GN=MLLT4 PE=1 SV=3 PF16011//PF00788//PF08272//PF00595//PF00498//PF13180//PF04977 Carbohydrate-binding family 9//Ras association (RalGDS/AF-6) domain//Topoisomerase I zinc-ribbon-like//PDZ domain (Also known as DHR or GLGF)//FHA domain//PDZ domain//Septum formation initiator GO:0016052//GO:0007049//GO:0006265//GO:0005975//GO:0007165 carbohydrate catabolic process//cell cycle//DNA topological change//carbohydrate metabolic process//signal transduction GO:0003918//GO:0030246//GO:0005515//GO:0004553//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//carbohydrate binding//protein binding//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding GO:0005694 chromosome KOG1892 Actin filament-binding protein Afadin Cluster-8309.3104 BF_2 16.00 0.83 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31043 BF_2 18.00 0.67 1406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31045 BF_2 628.51 7.13 3976 189242201 XP_972508.2 887 3.6e-92 PREDICTED: protein suppressor of white apricot, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12297 432 8.6e-41 Protein suppressor of white apricot OS=Drosophila melanogaster GN=su(w[a]) PE=1 SV=3 PF01805//PF04277//PF07127 Surp module//Oxaloacetate decarboxylase, gamma chain//Late nodulin protein GO:0006525//GO:0006560//GO:0006090//GO:0009878//GO:0071436//GO:0006814//GO:0006396 arginine metabolic process//proline metabolic process//pyruvate metabolic process//nodule morphogenesis//sodium ion export//sodium ion transport//RNA processing GO:0003723//GO:0008948//GO:0046872//GO:0015081 RNA binding//oxaloacetate decarboxylase activity//metal ion binding//sodium ion transmembrane transporter activity GO:0016020 membrane KOG1847 mRNA splicing factor Cluster-8309.31046 BF_2 31.11 977.32 207 302393781 P62976.2 342 2.9e-30 RecName: Full=Polyubiquitin; Contains: RecName: Full=Ubiquitin; Contains: RecName: Full=Ubiquitin-related 1; Contains: RecName: Full=Ubiquitin-related 2; Flags: Precursor [Cricetulus griseus]>gi|940395|dbj|BAA09853.1| polyubiquitin [Cricetulus sp.] 827025200 LM524971.1 107 2.65268e-47 Strongyloides venezuelensis genome assembly S_venezuelensis_HH1, scaffold SVE_scaffold0000003 K04551 UBB ubiquitin B http://www.genome.jp/dbget-bin/www_bget?ko:K04551 P0CG65 342 1.2e-31 Polyubiquitin-B OS=Pan troglodytes GN=UBB PE=3 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.31049 BF_2 50.00 2.45 1142 270001371 EEZ97818.1 226 4.6e-16 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914994 XM_008192253.1 106 6.03687e-46 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X5, mRNA -- -- -- -- Q7TMK9 139 2.3e-07 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.31050 BF_2 788.58 10.72 3363 91093162 XP_967461.1 1758 3.1e-193 PREDICTED: nucleolar complex protein 4 homolog B [Tribolium castaneum]>gi|270012948|gb|EFA09396.1| hypothetical protein TcasGA2_TC004314 [Tribolium castaneum] -- -- -- -- -- K14771 NOC4, UTP19 U3 small nucleolar RNA-associated protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K14771 Q6NRQ2 650 3.8e-66 Nucleolar complex protein 4 homolog A OS=Xenopus laevis GN=noc4l-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2154 Predicted nucleolar protein involved in ribosome biogenesis Cluster-8309.31051 BF_2 47.64 0.56 3875 91082907 XP_972373.1 1236 1.2e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.9e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF12740//PF00326//PF10503//PF00787//PF07224 Chlorophyllase enzyme//Prolyl oligopeptidase family//Esterase PHB depolymerase//PX domain//Chlorophyllase GO:0006508//GO:0046294//GO:0015994//GO:0015996//GO:0015947 proteolysis//formaldehyde catabolic process//chlorophyll metabolic process//chlorophyll catabolic process//methane metabolic process GO:0008236//GO:0018738//GO:0035091//GO:0047746 serine-type peptidase activity//S-formylglutathione hydrolase activity//phosphatidylinositol binding//chlorophyllase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.31055 BF_2 154.91 15.15 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31057 BF_2 6.00 58.35 234 642922790 XP_008193326.1 181 1.5e-11 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19015 ITIH2, SHAP inter-alpha-trypsin inhibitor heavy chain H2 http://www.genome.jp/dbget-bin/www_bget?ko:K19015 P19823 178 1.4e-12 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens GN=ITIH2 PE=1 SV=2 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.31060 BF_2 1235.61 45.19 1431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03286//PF02178 Pox virus Ag35 surface protein//AT hook motif -- -- GO:0003677 DNA binding GO:0019031 viral envelope -- -- Cluster-8309.31062 BF_2 649.00 29.81 1198 873236768 CEL98446.1 637 1.1e-63 unnamed protein product [Vitrella brassicaformis CCMP3155] 70909910 AM049142.1 149 7.90946e-70 Carabus granulatus mRNA for ribosomal protein Ubq/L40e (ubiquitin/rpL40e gene) K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH06 621 3.1e-63 Ubiquitin-60S ribosomal protein L40 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubi1 PE=1 SV=1 PF01020//PF14560//PF00240 Ribosomal L40e family//Ubiquitin-like domain//Ubiquitin family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-8309.31064 BF_2 9.00 0.38 1275 270009427 EFA05875.1 139 6.3e-06 hypothetical protein TcasGA2_TC008684 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31065 BF_2 41.81 0.69 2821 91080457 XP_969840.1 1905 2.3e-210 PREDICTED: TBC1 domain family member 15 [Tribolium castaneum]>gi|270005762|gb|EFA02210.1| hypothetical protein TcasGA2_TC007868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CXF4 982 1.0e-104 TBC1 domain family member 15 OS=Mus musculus GN=Tbc1d15 PE=1 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.31066 BF_2 172.11 5.41 1619 478250454 ENN70949.1 770 5.4e-79 hypothetical protein YQE_12350, partial [Dendroctonus ponderosae]>gi|546677323|gb|ERL88180.1| hypothetical protein D910_05568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31067 BF_2 12.02 0.80 912 478250454 ENN70949.1 223 8.2e-16 hypothetical protein YQE_12350, partial [Dendroctonus ponderosae]>gi|546677323|gb|ERL88180.1| hypothetical protein D910_05568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31070 BF_2 37.42 1.83 1142 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.31071 BF_2 71.00 5.85 795 642927986 XP_008195473.1 293 5.5e-24 PREDICTED: uncharacterized protein LOC103313592 [Tribolium castaneum]>gi|270010273|gb|EFA06721.1| hypothetical protein TcasGA2_TC009652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31072 BF_2 118.00 5.35 1210 478257154 ENN77317.1 341 2.3e-29 hypothetical protein YQE_06143, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31074 BF_2 28.79 0.67 2079 642915202 XP_008190517.1 275 1.7e-21 PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum]>gi|642915204|ref|XP_008190519.1| PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31075 BF_2 454.00 63.54 586 91078158 XP_973931.1 545 2.4e-53 PREDICTED: 14 kDa phosphohistidine phosphatase [Tribolium castaneum]>gi|270002348|gb|EEZ98795.1| hypothetical protein TcasGA2_TC001359 [Tribolium castaneum] -- -- -- -- -- K01112 PHPT1 phosphohistidine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01112 Q32PA4 311 1.4e-27 14 kDa phosphohistidine phosphatase OS=Bos taurus GN=PHPT1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31076 BF_2 153.68 3.25 2265 478262409 ENN81080.1 851 3.1e-88 hypothetical protein YQE_02449, partial [Dendroctonus ponderosae] -- -- -- -- -- K06633 PKMYT membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06633 Q9NI63 527 4.7e-52 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase OS=Drosophila melanogaster GN=Myt1 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0601 Cyclin-dependent kinase WEE1 Cluster-8309.31077 BF_2 111.32 1.95 2671 478262409 ENN81080.1 851 3.6e-88 hypothetical protein YQE_02449, partial [Dendroctonus ponderosae] -- -- -- -- -- K06633 PKMYT membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06633 Q9NI63 527 5.5e-52 Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase OS=Drosophila melanogaster GN=Myt1 PE=1 SV=2 PF00069//PF08138//PF07714 Protein kinase domain//Sex peptide (SP) family//Protein tyrosine kinase GO:0006468//GO:0046008//GO:0007165 protein phosphorylation//regulation of female receptivity, post-mating//signal transduction GO:0004672//GO:0005179//GO:0005524 protein kinase activity//hormone activity//ATP binding GO:0005576 extracellular region KOG0601 Cyclin-dependent kinase WEE1 Cluster-8309.31078 BF_2 83.55 2.96 1466 724970788 XP_010357705.1 695 2.4e-70 PREDICTED: myosin light chain alkali-like [Rhinopithecus roxellana] 724970787 XM_010359403.1 423 0 PREDICTED: Rhinopithecus roxellana myosin light chain alkali-like (LOC104659290), mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24756 399 2.1e-37 Myosin light chain alkali OS=Drosophila virilis GN=Mlc1 PE=3 SV=1 PF00036//PF13405//PF13499 EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.31079 BF_2 668.56 14.96 2157 642931776 XP_008196723.1 2390 1.0e-266 PREDICTED: alkyldihydroxyacetonephosphate synthase [Tribolium castaneum]>gi|270012218|gb|EFA08666.1| hypothetical protein TcasGA2_TC006332 [Tribolium castaneum] -- -- -- -- -- K00803 AGPS, agpS alkyldihydroxyacetonephosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00803 Q9V778 1848 3.0e-205 Alkyldihydroxyacetonephosphate synthase OS=Drosophila melanogaster GN=CG10253 PE=2 SV=1 PF02913//PF01565 FAD linked oxidases, C-terminal domain//FAD binding domain GO:0046486//GO:0055114//GO:0008610//GO:0006040 glycerolipid metabolic process//oxidation-reduction process//lipid biosynthetic process//amino sugar metabolic process GO:0050660//GO:0008762//GO:0016491//GO:0008609//GO:0003824 flavin adenine dinucleotide binding//UDP-N-acetylmuramate dehydrogenase activity//oxidoreductase activity//alkylglycerone-phosphate synthase activity//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.3108 BF_2 17.00 0.70 1304 642914631 XP_008190292.1 393 2.3e-35 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0003676//GO:0016787 metal ion binding//nucleic acid binding//hydrolase activity -- -- -- -- Cluster-8309.31081 BF_2 42.12 7.13 534 642912272 XP_008200632.1 255 9.3e-20 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 130 1.2e-06 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31082 BF_2 1.00 13.37 226 546677957 ERL88690.1 143 3.8e-07 hypothetical protein D910_06073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31083 BF_2 391.05 5.85 3083 642912272 XP_008200632.1 657 1.3e-65 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 279 3.7e-23 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF00757 Trypsin//Furin-like cysteine rich region GO:0006508//GO:0006468//GO:0007169 proteolysis//protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0004252//GO:0004714 ATP binding//serine-type endopeptidase activity//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane -- -- Cluster-8309.31085 BF_2 2.00 0.72 403 170321839 BAG14264.1 168 8.6e-10 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31086 BF_2 71.18 3.21 1216 150416593 ABF60889.2 189 9.6e-12 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31087 BF_2 204.64 1.00 8874 642918656 XP_008191524.1 2201 3.5e-244 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 1975 2.3e-219 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00069//PF07714//PF00433//PF01799//PF06220//PF07535//PF00463 Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain//[2Fe-2S] binding domain//U1 zinc finger//DBF zinc finger//Isocitrate lyase family GO:0055114//GO:0006097//GO:0009069//GO:0006468//GO:0016310//GO:0019752 oxidation-reduction process//glyoxylate cycle//serine family amino acid metabolic process//protein phosphorylation//phosphorylation//carboxylic acid metabolic process GO:0004672//GO:0046872//GO:0004674//GO:0008270//GO:0003676//GO:0005543//GO:0004451//GO:0016491//GO:0005524 protein kinase activity//metal ion binding//protein serine/threonine kinase activity//zinc ion binding//nucleic acid binding//phospholipid binding//isocitrate lyase activity//oxidoreductase activity//ATP binding -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.31089 BF_2 248.83 1.38 7852 642918656 XP_008191524.1 2229 1.7e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.2e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00069//PF01799//PF00433//PF07714//PF07535//PF06220//PF00463 Protein kinase domain//[2Fe-2S] binding domain//Protein kinase C terminal domain//Protein tyrosine kinase//DBF zinc finger//U1 zinc finger//Isocitrate lyase family GO:0006097//GO:0055114//GO:0006468//GO:0009069//GO:0016310//GO:0019752 glyoxylate cycle//oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//carboxylic acid metabolic process GO:0008270//GO:0003676//GO:0046872//GO:0004674//GO:0004672//GO:0005524//GO:0005543//GO:0016491//GO:0004451 zinc ion binding//nucleic acid binding//metal ion binding//protein serine/threonine kinase activity//protein kinase activity//ATP binding//phospholipid binding//oxidoreductase activity//isocitrate lyase activity -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.31091 BF_2 151.38 5.35 1470 820848889 XP_012342205.1 150 3.9e-07 PREDICTED: LOW QUALITY PROTEIN: thyroid transcription factor 1-associated protein 26 [Apis florea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31096 BF_2 221.00 7.40 1536 642935236 XP_968858.3 1047 3.9e-111 PREDICTED: RNA methyltransferase-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q566V3 473 5.8e-46 rRNA methyltransferase 3A, mitochondrial OS=Danio rerio GN=rnmtl1a PE=2 SV=1 PF08032//PF00588 RNA 2'-O ribose methyltransferase substrate binding//SpoU rRNA Methylase family GO:0006396//GO:0009451 RNA processing//RNA modification GO:0008173//GO:0003723//GO:0008168 RNA methyltransferase activity//RNA binding//methyltransferase activity -- -- -- -- Cluster-8309.31098 BF_2 111.29 0.91 5400 270015831 EFA12279.1 790 8.7e-81 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09106//PF08398 Elongation factor SelB, winged helix//Parvovirus coat protein VP1 GO:0006448//GO:0001514 regulation of translational elongation//selenocysteine incorporation GO:0005198//GO:0003723//GO:0003746//GO:0005525 structural molecule activity//RNA binding//translation elongation factor activity//GTP binding GO:0019028//GO:0005737//GO:0005840 viral capsid//cytoplasm//ribosome -- -- Cluster-8309.31099 BF_2 16.92 0.49 1724 642927770 XP_008195398.1 656 9.6e-66 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 7.1e-08 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.31100 BF_2 129.01 3.92 1664 642927770 XP_008195398.1 685 4.0e-69 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 6.8e-08 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.31101 BF_2 113.45 0.85 5857 642927862 XP_008195429.1 2663 6.1e-298 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X2 [Tribolium castaneum]>gi|270009857|gb|EFA06305.1| hypothetical protein TcasGA2_TC009173 [Tribolium castaneum] 662183442 XM_008489250.1 153 2.36505e-71 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA K13297 PTPRT receptor-type tyrosine-protein phosphatase T http://www.genome.jp/dbget-bin/www_bget?ko:K13297 Q99M80 957 1.7e-101 Receptor-type tyrosine-protein phosphatase T OS=Mus musculus GN=Ptprt PE=2 SV=2 PF00041//PF00102//PF07973//PF00641//PF00782 Fibronectin type III domain//Protein-tyrosine phosphatase//Threonyl and Alanyl tRNA synthetase second additional domain//Zn-finger in Ran binding protein and others//Dual specificity phosphatase, catalytic domain GO:0035335//GO:0043039//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//tRNA aminoacylation//protein dephosphorylation//tyrosine metabolic process GO:0016876//GO:0008270//GO:0004725//GO:0008138//GO:0005515//GO:0005524 ligase activity, forming aminoacyl-tRNA and related compounds//zinc ion binding//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//ATP binding -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.31103 BF_2 589.00 16.57 1774 91079690 XP_968122.1 1780 4.6e-196 PREDICTED: CDK5 regulatory subunit-associated protein 3 [Tribolium castaneum]>gi|270004493|gb|EFA00941.1| hypothetical protein TcasGA2_TC003848 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLH7 991 5.8e-106 CDK5 regulatory subunit-associated protein 3 OS=Rattus norvegicus GN=Cdk5rap3 PE=1 SV=1 PF10018//PF04152//PF04977 Vitamin-D-receptor interacting Mediator subunit 4//Mre11 DNA-binding presumed domain//Septum formation initiator GO:0007049//GO:0006302//GO:0006357 cell cycle//double-strand break repair//regulation of transcription from RNA polymerase II promoter GO:0030145//GO:0004519//GO:0001104 manganese ion binding//endonuclease activity//RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592 nucleus//mediator complex KOG2607 CDK5 activator-binding protein Cluster-8309.31104 BF_2 49.00 10.05 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31106 BF_2 1485.94 32.86 2179 170321839 BAG14264.1 720 4.6e-73 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8CFG8 240 8.6e-19 Complement C1s-B subcomponent OS=Mus musculus GN=C1sb PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31107 BF_2 32.00 6.44 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03609 PTS system sorbose-specific iic component GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31108 BF_2 164.64 4.42 1846 642916020 XP_008190860.1 1276 1.3e-137 PREDICTED: GTP-binding protein GEM [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55040 254 1.7e-20 GTP-binding protein GEM OS=Homo sapiens GN=GEM PE=1 SV=1 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.31109 BF_2 448.26 10.51 2071 741829513 AJA91072.1 1520 7.5e-166 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1033 9.1e-111 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.31111 BF_2 124.36 4.14 1543 642916020 XP_008190860.1 1254 3.9e-135 PREDICTED: GTP-binding protein GEM [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55040 254 1.5e-20 GTP-binding protein GEM OS=Homo sapiens GN=GEM PE=1 SV=1 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0395 Ras-related GTPase Cluster-8309.31112 BF_2 9.50 0.42 1230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31113 BF_2 103.71 3.64 1480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0016567//GO:0072519 protein ubiquitination//parasitism GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.31114 BF_2 144.29 6.82 1172 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0016567//GO:0072519 protein ubiquitination//parasitism GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.31115 BF_2 8.00 1.01 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02038 ATP1G1/PLM/MAT8 family GO:0006811 ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.31116 BF_2 9.00 13.43 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31117 BF_2 4074.57 92.19 2136 385845164 AFI81409.1 1440 1.5e-156 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 57 1.98386e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 586 6.4e-59 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF08127//PF03099 Peptidase family C1 propeptide//Biotin/lipoate A/B protein ligase family GO:0006464//GO:0006508//GO:0050790 cellular protein modification process//proteolysis//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.31118 BF_2 21.00 1.08 1104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31120 BF_2 557.07 10.01 2615 546683891 ERL93639.1 1009 1.7e-106 hypothetical protein D910_10927 [Dendroctonus ponderosae] -- -- -- -- -- K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 Q9NZR2 179 1.2e-11 Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens GN=LRP1B PE=1 SV=2 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.31121 BF_2 117.91 1.26 4191 270010219 EFA06667.1 2551 4.3e-285 hypothetical protein TcasGA2_TC009594 [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 951 5.9e-101 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.31124 BF_2 229.00 1.40 7141 102939 2519 3.7e-281 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1517 2.4e-166 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF03539 Integrase core domain//Spumavirus aspartic protease (A9) GO:0006508//GO:0015074 proteolysis//DNA integration GO:0004190 aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.31125 BF_2 168.02 2.16 3539 91092208 XP_969730.1 777 1.8e-79 PREDICTED: protein unc-50 homolog [Tribolium castaneum]>gi|270014482|gb|EFA10930.1| hypothetical protein TcasGA2_TC001757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VHN5 706 1.3e-72 Protein unc-50 homolog OS=Drosophila melanogaster GN=CG9773 PE=1 SV=1 PF02703 Early E1A protein GO:0019048//GO:0006355 modulation by virus of host morphology or physiology//regulation of transcription, DNA-templated -- -- -- -- KOG3012 Uncharacterized conserved protein Cluster-8309.31126 BF_2 1193.26 27.16 2125 91090858 XP_967143.1 786 1.0e-80 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 603 6.8e-61 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF04546//PF00191 Sigma-70, non-essential region//Annexin GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0016987//GO:0005509//GO:0003700//GO:0005544//GO:0003677 sigma factor activity//calcium ion binding//transcription factor activity, sequence-specific DNA binding//calcium-dependent phospholipid binding//DNA binding GO:0005667 transcription factor complex KOG0819 Annexin Cluster-8309.31127 BF_2 245.21 7.71 1618 91078920 XP_973689.1 883 4.3e-92 PREDICTED: ubiquitin-conjugating enzyme E2 G2 [Tribolium castaneum]>gi|270004881|gb|EFA01329.1| courtless [Tribolium castaneum] 827562182 XM_004933089.2 186 2.90979e-90 PREDICTED: Bombyx mori ubiquitin-conjugating enzyme E2 G2 (LOC101745353), mRNA K04555 UBE2G2, UBC7 ubiquitin-conjugating enzyme E2 G2 http://www.genome.jp/dbget-bin/www_bget?ko:K04555 Q5RF84 769 2.9e-80 Ubiquitin-conjugating enzyme E2 G2 OS=Pongo abelii GN=UBE2G2 PE=2 SV=1 PF05615 Tho complex subunit 7 GO:0006397 mRNA processing GO:0005524//GO:0016881 ATP binding//acid-amino acid ligase activity GO:0000445 THO complex part of transcription export complex KOG0426 Ubiquitin-protein ligase Cluster-8309.31128 BF_2 1199.00 13.20 4086 291463256 NP_001167547.1 3312 0.0e+00 uncharacterized protein LOC100381254 precursor [Tribolium castaneum]>gi|270014696|gb|EFA11144.1| hypothetical protein TcasGA2_TC004746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GQT9 1063 6.0e-114 Nodal modulator 1 OS=Mus musculus GN=Nomo1 PE=1 SV=1 PF00041//PF00775//PF01105 Fibronectin type III domain//Dioxygenase//emp24/gp25L/p24 family/GOLD GO:0055114//GO:0006725//GO:0006810 oxidation-reduction process//cellular aromatic compound metabolic process//transport GO:0005515//GO:0008199//GO:0003824 protein binding//ferric iron binding//catalytic activity GO:0016021 integral component of membrane KOG1948 Metalloproteinase-related collagenase pM5 Cluster-8309.31134 BF_2 2.00 0.44 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31135 BF_2 27.00 225.81 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31137 BF_2 250.01 3.21 3546 642936430 XP_008198431.1 1069 2.5e-113 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X3 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.17492e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 447 1.4e-42 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31138 BF_2 1382.84 22.83 2821 91094821 XP_971003.1 1193 8.5e-128 PREDICTED: proteasome subunit beta type-7 [Tribolium castaneum]>gi|270006571|gb|EFA03019.1| hypothetical protein TcasGA2_TC010442 [Tribolium castaneum] 847169839 XM_002938748.3 97 1.5272e-40 PREDICTED: Xenopus (Silurana) tropicalis proteasome (prosome, macropain) subunit, beta type, 7 (psmb7), mRNA K02739 PSMB7 20S proteasome subunit beta 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02739 Q9JHW0 923 7.1e-98 Proteasome subunit beta type-7 OS=Rattus norvegicus GN=Psmb7 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839 cytoplasm//nucleus//proteasome core complex KOG0173 20S proteasome, regulatory subunit beta type PSMB7/PSMB10/PUP1 Cluster-8309.31139 BF_2 130.00 1.80 3309 189240813 XP_001811587.1 1811 2.2e-199 PREDICTED: 4-aminobutyrate aminotransferase, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 P61922 1303 7.2e-142 4-aminobutyrate aminotransferase, mitochondrial OS=Mus musculus GN=Abat PE=1 SV=1 PF01335//PF00202//PF00155 Death effector domain//Aminotransferase class-III//Aminotransferase class I and II GO:0009058//GO:0042981 biosynthetic process//regulation of apoptotic process GO:0005515//GO:0008483//GO:0030170 protein binding//transaminase activity//pyridoxal phosphate binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.3114 BF_2 5.00 1.01 494 803217189 XP_011968949.1 768 2.8e-79 PREDICTED: 40S ribosomal protein S23 isoform X2 [Ovis aries musimon] 426349371 XM_004042233.1 494 0 PREDICTED: Gorilla gorilla gorilla ribosomal protein S23 (RPS23), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 P62298 745 5.4e-78 40S ribosomal protein S23 OS=Chinchilla lanigera GN=RPS23 PE=2 SV=1 PF00164 Ribosomal protein S12/S23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1749 40S ribosomal protein S23 Cluster-8309.31140 BF_2 414.81 2.14 8409 91085437 XP_968834.1 1867 1.8e-205 PREDICTED: protein zyg-11 homolog [Tribolium castaneum]>gi|270009168|gb|EFA05616.1| hypothetical protein TcasGA2_TC015823 [Tribolium castaneum] 462389525 APGK01019132.1 136 9.58924e-62 Dendroctonus ponderosae Seq01019142, whole genome shotgun sequence K10350 ZYG11 Zyg-11 protein homolog http://www.genome.jp/dbget-bin/www_bget?ko:K10350 Q3UFS0 750 2.4e-77 Protein zyg-11 homolog B OS=Mus musculus GN=Zyg11b PE=2 SV=2 PF13855//PF00073//PF02985//PF08711 Leucine rich repeat//picornavirus capsid protein//HEAT repeat//TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677//GO:0005515//GO:0005198 DNA binding//protein binding//structural molecule activity GO:0005634//GO:0019028 nucleus//viral capsid KOG3665 ZYG-1-like serine/threonine protein kinases Cluster-8309.31143 BF_2 921.87 13.90 3061 270016487 EFA12933.1 2989 0.0e+00 hypothetical protein TcasGA2_TC010479 [Tribolium castaneum] 551663104 XM_005834260.1 42 6.22485e-10 Guillardia theta CCMP2712 hypothetical protein (GUITHDRAFT_157624) mRNA, complete cds K01895 ACSS, acs acetyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01895 Q9VP61 2713 2.1e-305 Acetyl-coenzyme A synthetase OS=Drosophila melanogaster GN=AcCoAS PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.31144 BF_2 714.55 3.96 7840 642930792 XP_008196093.1 1558 1.1e-169 PREDICTED: ski oncogene [Tribolium castaneum] 759170310 XM_011377342.1 126 3.23732e-56 PREDICTED: Pteropus vampyrus SKI proto-oncogene (SKI), partial mRNA -- -- -- -- P49140 698 2.4e-71 Ski oncogene OS=Gallus gallus GN=SKI PE=1 SV=1 PF11365//PF08782 Protein of unknown function (DUF3166)//c-SKI Smad4 binding domain GO:0010506 regulation of autophagy GO:0046332 SMAD binding GO:0005615 extracellular space -- -- Cluster-8309.31145 BF_2 253.00 8.54 1527 546676940 ERL87864.1 798 2.9e-82 hypothetical protein D910_05252 [Dendroctonus ponderosae] -- -- -- -- -- K08509 SNAP29 synaptosomal-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K08509 Q9ERB0 266 5.8e-22 Synaptosomal-associated protein 29 OS=Mus musculus GN=Snap29 PE=2 SV=1 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.31148 BF_2 2334.00 148.42 945 91083623 XP_970124.1 998 1.2e-105 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] -- -- -- -- -- K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q16P20 888 2.7e-94 Probable citrate synthase 2, mitochondrial OS=Aedes aegypti GN=AAEL011789 PE=3 SV=1 PF00285 Citrate synthase GO:0006099//GO:0044262//GO:0046487 tricarboxylic acid cycle//cellular carbohydrate metabolic process//glyoxylate metabolic process GO:0046912//GO:0004108 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//citrate (Si)-synthase activity -- -- KOG2617 Citrate synthase Cluster-8309.31149 BF_2 609.16 3.74 7093 478254018 ENN74310.1 6609 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 242005974 XM_002423790.1 223 3.50332e-110 Pediculus humanus corporis jumonji/arid domain-containing protein, putative, mRNA K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3573 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF08429//PF01388//PF00628 PLU-1-like protein//ARID/BRIGHT DNA binding domain//PHD-finger GO:0055114 oxidation-reduction process GO:0003677//GO:0016706//GO:0005515 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.3115 BF_2 1.00 1.46 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31151 BF_2 298.85 3.04 4403 91093481 XP_968172.1 1641 1.5e-179 PREDICTED: WD repeat domain phosphoinositide-interacting protein 3 [Tribolium castaneum]>gi|270012665|gb|EFA09113.1| hypothetical protein TcasGA2_TC015973 [Tribolium castaneum] 766932181 XM_011500000.1 121 1.09076e-53 PREDICTED: Ceratosolen solmsi marchali WD repeat domain phosphoinositide-interacting protein 3 (LOC105362539), mRNA -- -- -- -- Q9CR39 1375 4.3e-150 WD repeat domain phosphoinositide-interacting protein 3 OS=Mus musculus GN=Wdr45b PE=2 SV=2 PF04584//PF00240//PF03178//PF14560//PF00400 Poxvirus A28 family//Ubiquitin family//CPSF A subunit region//Ubiquitin-like domain//WD domain, G-beta repeat GO:0016032 viral process GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0019031//GO:0005634 viral envelope//nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.31152 BF_2 709.00 38.33 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31153 BF_2 2.00 0.39 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31155 BF_2 9.00 3.71 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31159 BF_2 44.86 3.20 874 91087735 XP_974721.1 500 6.0e-48 PREDICTED: synaptosomal-associated protein 25 isoform X3 [Tribolium castaneum] 642930445 XM_969628.2 155 2.63998e-73 PREDICTED: Tribolium castaneum synaptosomal-associated protein 25 (LOC663588), transcript variant X3, mRNA K18211 SNAP25 synaptosomal-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K18211 P36975 377 4.5e-35 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 PF02321//PF05739 Outer membrane efflux protein//SNARE domain GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.31160 BF_2 61.10 1.58 1901 91087735 XP_974721.1 286 8.5e-23 PREDICTED: synaptosomal-associated protein 25 isoform X3 [Tribolium castaneum] 642930445 XM_969628.2 92 6.16034e-38 PREDICTED: Tribolium castaneum synaptosomal-associated protein 25 (LOC663588), transcript variant X3, mRNA K18211 SNAP25 synaptosomal-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K18211 P36975 178 1.2e-11 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.31161 BF_2 232.25 1.48 6867 91077500 XP_969314.1 3473 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.04841e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2093 3.7e-233 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF00588//PF07544 SpoU rRNA Methylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0009451//GO:0006357//GO:0006396 RNA modification//regulation of transcription from RNA polymerase II promoter//RNA processing GO:0001104//GO:0003723//GO:0008173 RNA polymerase II transcription cofactor activity//RNA binding//RNA methyltransferase activity GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.31162 BF_2 62.35 1.40 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31163 BF_2 1017.14 6.06 7305 270008334 EFA04782.1 2089 2.8e-231 hypothetical protein TcasGA2_TC030779 [Tribolium castaneum] -- -- -- -- -- K10630 RBCK1, HOIL1 RanBP-type and C3HC4-type zinc finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10630 E6ZIJ1 896 2.5e-94 RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Dicentrarchus labrax GN=rbck1 PE=3 SV=1 PF13639//PF09174//PF00641//PF14634//PF00240//PF00097 Ring finger domain//Maf1 regulator//Zn-finger in Ran binding protein and others//zinc-RING finger domain//Ubiquitin family//Zinc finger, C3HC4 type (RING finger) GO:0016480 negative regulation of transcription from RNA polymerase III promoter GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.31164 BF_2 325.68 6.03 2547 91085733 XP_973505.1 2855 0.0e+00 PREDICTED: tRNA (cytosine(34)-C(5))-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15335 NSUN2 tRNA (cytosine34-C5)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15335 Q9W4M9 1723 1.1e-190 tRNA (cytosine(34)-C(5))-methyltransferase OS=Drosophila melanogaster GN=Nsun2 PE=2 SV=1 PF01728//PF01189 FtsJ-like methyltransferase//16S rRNA methyltransferase RsmF GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG2198 tRNA cytosine-5-methylases and related enzymes of the NOL1/NOP2/sun superfamily Cluster-8309.31165 BF_2 178.15 14.12 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31167 BF_2 10.00 0.74 852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31168 BF_2 43.00 1.93 1221 332374600 AEE62441.1 441 5.8e-41 unknown [Dendroctonus ponderosae]>gi|478260324|gb|ENN80075.1| hypothetical protein YQE_03491, partial [Dendroctonus ponderosae] 723569508 XM_010306612.1 99 5.0292e-42 PREDICTED: Balearica regulorum gibbericeps protein mab-21-like 2 (LOC104638742), mRNA -- -- -- -- Q5TW90 402 7.9e-38 Protein mab-21 OS=Anopheles gambiae GN=mab-21 PE=3 SV=3 PF08476 Viral D10 N-terminal -- -- GO:0016791 phosphatase activity -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.31169 BF_2 39.01 0.82 2271 91088603 XP_973741.1 1088 1.0e-115 PREDICTED: sodium-dependent nutrient amino acid transporter 1 [Tribolium castaneum]>gi|642931940|ref|XP_008196786.1| PREDICTED: sodium-dependent nutrient amino acid transporter 1 [Tribolium castaneum]>gi|270012259|gb|EFA08707.1| hypothetical protein TcasGA2_TC006378 [Tribolium castaneum] 602654660 XM_007433088.1 38 7.70192e-08 PREDICTED: Python bivittatus solute carrier family 6 (neurotransmitter transporter), member 2 (SLC6A2), mRNA K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 B4MEG2 791 1.2e-82 Sodium-dependent nutrient amino acid transporter 1 OS=Drosophila virilis GN=NAAT1 PE=3 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.31170 BF_2 635.16 33.56 1079 91079744 XP_970506.1 444 2.3e-41 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 170043821 XM_001849518.1 105 2.04779e-45 Culex quinquefasciatus acyl-coa dehydrogenase, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 404 4.1e-38 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF00441 Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.31174 BF_2 2551.70 36.71 3195 642939454 XP_008200409.1 1602 3.6e-175 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|270016515|gb|EFA12961.1| hypothetical protein TcasGA2_TC001412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 697 1.3e-71 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.31175 BF_2 278.00 23.04 792 -- -- -- -- -- 642938586 XM_008201631.1 46 9.32733e-13 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31176 BF_2 1098.11 23.79 2218 642938587 XP_008199853.1 2711 6.3e-304 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 642938586 XM_008201631.1 732 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X6, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 Q16720 1836 7.5e-204 Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens GN=ATP2B3 PE=1 SV=3 PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0005388 calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.31179 BF_2 144.21 3.42 2052 642933218 XP_008197312.1 1186 4.0e-127 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61369 762 2.4e-79 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.31180 BF_2 57.63 0.76 3480 642938000 XP_008199165.1 535 2.1e-51 PREDICTED: uncharacterized protein LOC103314560 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 197 1.3e-13 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31181 BF_2 188.88 3.89 2316 642938000 XP_008199165.1 624 6.6e-62 PREDICTED: uncharacterized protein LOC103314560 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 197 8.9e-14 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31183 BF_2 1516.64 7.72 8506 270012222 EFA08670.1 2246 2.0e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 413 2.9e-38 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF06974//PF03376//PF00083//PF01277//PF04661//PF07690//PF03007 Protein of unknown function (DUF1298)//Adenovirus E3B protein//Sugar (and other) transporter//Oleosin//Poxvirus I3 ssDNA-binding protein//Major Facilitator Superfamily//Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0045017//GO:0055085//GO:0042967//GO:0046486 glycerolipid biosynthetic process//transmembrane transport//acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0003697//GO:0022857//GO:0004144 single-stranded DNA binding//transmembrane transporter activity//diacylglycerol O-acyltransferase activity GO:0016021//GO:0012511//GO:0016020 integral component of membrane//monolayer-surrounded lipid storage body//membrane KOG2504 Monocarboxylate transporter Cluster-8309.31184 BF_2 17.38 0.36 2306 642925628 XP_008194647.1 253 6.9e-19 PREDICTED: endothelin-converting enzyme 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P97739 194 2.0e-13 Endothelin-converting enzyme 1 OS=Cavia porcellus GN=ECE1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3624 M13 family peptidase Cluster-8309.31187 BF_2 559.00 15.04 1842 91087867 XP_969419.1 2113 1.2e-234 PREDICTED: histone deacetylase 3 [Tribolium castaneum]>gi|270012009|gb|EFA08457.1| hypothetical protein TcasGA2_TC006104 [Tribolium castaneum] 195568433 XM_002102185.1 244 1.90246e-122 Drosophila simulans GD19615 (Dsim\GD19615), mRNA K11404 HDAC3 histone deacetylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11404 Q28DV3 1671 8.5e-185 Histone deacetylase 3 OS=Xenopus tropicalis GN=hdac3 PE=2 SV=1 -- -- GO:0070933//GO:0070932//GO:0006807//GO:0006355 histone H4 deacetylation//histone H3 deacetylation//nitrogen compound metabolic process//regulation of transcription, DNA-templated GO:0032041//GO:0046970//GO:0046969//GO:0097372 NAD-dependent histone deacetylase activity (H3-K14 specific)//NAD-dependent histone deacetylase activity (H4-K16 specific)//NAD-dependent histone deacetylase activity (H3-K9 specific)//NAD-dependent histone deacetylase activity (H3-K18 specific) GO:0005634//GO:0000118 nucleus//histone deacetylase complex KOG1342 Histone deacetylase complex, catalytic component RPD3 Cluster-8309.31189 BF_2 734.23 37.65 1103 642915807 XP_008200086.1 1563 4.1e-171 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 210 8.95299e-104 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- Q8CGF6 945 7.8e-101 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.31191 BF_2 847.21 5.95 6240 642923135 XP_008193624.1 2610 9.2e-292 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Tribolium castaneum] 642923146 XM_008195408.1 389 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.2e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- -- -- Cluster-8309.31192 BF_2 22.50 0.33 3102 642910837 XP_971522.2 2676 1.0e-299 PREDICTED: probable DNA mismatch repair protein Msh6 [Tribolium castaneum] -- -- -- -- -- K08737 MSH6 DNA mismatch repair protein MSH6 http://www.genome.jp/dbget-bin/www_bget?ko:K08737 Q9VUM0 1766 1.4e-195 Probable DNA mismatch repair protein Msh6 OS=Drosophila melanogaster GN=Msh6 PE=1 SV=2 PF00995//PF00488//PF05188//PF05190//PF05192//PF01624 Sec1 family//MutS domain V//MutS domain II//MutS family domain IV//MutS domain III//MutS domain I GO:0006298//GO:0006904//GO:0016192 mismatch repair//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- KOG0217 Mismatch repair ATPase MSH6 (MutS family) Cluster-8309.31193 BF_2 1313.39 21.05 2897 264667471 ACY71321.1 794 1.6e-81 ribosomal biogenesis protein RLP24 [Chrysomela tremula] -- -- -- -- -- K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q9VGN9 595 7.8e-60 Probable ribosome biogenesis protein RLP24 OS=Drosophila melanogaster GN=RpL24-like PE=1 SV=1 PF06177//PF06305//PF02535 QueT transporter//Protein of unknown function (DUF1049)//ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0005887//GO:0005886//GO:0016020 integral component of plasma membrane//plasma membrane//membrane KOG1723 60s ribosomal protein L30 isolog Cluster-8309.31195 BF_2 223.21 1.85 5344 91078510 XP_969463.1 3397 0.0e+00 PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|642915541|ref|XP_008190658.1| PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|270003849|gb|EFA00297.1| hypothetical protein TcasGA2_TC003130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82094 856 7.9e-90 TATA element modulatory factor OS=Homo sapiens GN=TMF1 PE=1 SV=2 PF03376 Adenovirus E3B protein -- -- -- -- GO:0016020 membrane KOG4673 Transcription factor TMF, TATA element modulatory factor Cluster-8309.31196 BF_2 3328.00 9335.46 272 699254676 XP_009861483.1 224 1.9e-16 PREDICTED: uncharacterized protein LOC100178305 [Ciona intestinalis] -- -- -- -- -- -- -- -- -- P27951 188 1.1e-13 IgA FC receptor OS=Streptococcus agalactiae GN=bag PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31197 BF_2 5.00 0.74 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31198 BF_2 441.00 40.83 739 332377007 AEE63643.1 578 4.6e-57 unknown [Dendroctonus ponderosae]>gi|478257397|gb|ENN77553.1| hypothetical protein YQE_05849, partial [Dendroctonus ponderosae]>gi|546677759|gb|ERL88538.1| hypothetical protein D910_05923 [Dendroctonus ponderosae] 61651649 AB207213.1 74 2.36136e-28 Gastrophysa atrocyanea hsp 21 mRNA for small heat shock protein 21, complete cds K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 250 2.0e-20 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0006413//GO:0006446//GO:0007423 translational initiation//regulation of translational initiation//sensory organ development GO:0003743//GO:0005212 translation initiation factor activity//structural constituent of eye lens GO:0005840 ribosome -- -- Cluster-8309.31200 BF_2 201.88 2.52 3644 741829513 AJA91072.1 1393 7.0e-151 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 937 2.2e-99 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF15681//PF00067 Lymphocyte activation family X//Cytochrome P450 GO:0055114//GO:0051249//GO:0006955 oxidation-reduction process//regulation of lymphocyte activation//immune response GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.31201 BF_2 43.10 0.45 4250 642936481 XP_008198455.1 1005 8.0e-106 PREDICTED: beta-1,3-glucosyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K13675 B3GALTL UDP-glucose:O-linked fucose beta-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13675 Q8BHT6 785 1.1e-81 Beta-1,3-glucosyltransferase OS=Mus musculus GN=B3galtl PE=2 SV=3 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.31202 BF_2 596.21 7.50 3611 642919917 XP_008192124.1 1147 2.3e-122 PREDICTED: transmembrane 7 superfamily member 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS93 526 9.8e-52 Transmembrane 7 superfamily member 3 OS=Homo sapiens GN=TM7SF3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31203 BF_2 290.82 8.13 1783 478251095 ENN71571.1 2088 8.8e-232 hypothetical protein YQE_11671, partial [Dendroctonus ponderosae]>gi|546683211|gb|ERL93051.1| hypothetical protein D910_10353 [Dendroctonus ponderosae] 795042442 XM_012011877.1 144 7.15473e-67 PREDICTED: Vollenhovia emeryi CXXC-type zinc finger protein 1-like (LOC105561680), transcript variant X2, mRNA K14960 CXXC1, SPP1, CPS40 COMPASS component SPP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14960 Q9W352 1023 1.1e-109 CXXC-type zinc finger protein 1 OS=Drosophila melanogaster GN=Cfp1 PE=1 SV=1 PF00628//PF02008 PHD-finger//CXXC zinc finger domain -- -- GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding -- -- KOG1632 Uncharacterized PHD Zn-finger protein Cluster-8309.31204 BF_2 81.12 1.08 3435 91081375 XP_972116.1 4324 0.0e+00 PREDICTED: chromatin-remodeling complex ATPase chain Iswi [Tribolium castaneum]>gi|270005181|gb|EFA01629.1| hypothetical protein TcasGA2_TC007199 [Tribolium castaneum] 815799995 XR_001100589.1 645 0 PREDICTED: Linepithema humile chromatin-remodeling complex ATPase chain Iswi (LOC105671246), transcript variant X2, misc_RNA K11654 SMARCA5, SNF2H, ISWI SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11654 Q24368 3747 0.0e+00 Chromatin-remodeling complex ATPase chain Iswi OS=Drosophila melanogaster GN=Iswi PE=1 SV=1 PF09111//PF04851//PF05416//PF06422//PF00176//PF09110//PF13892//PF00270 SLIDE//Type III restriction enzyme, res subunit//Southampton virus-type processing peptidase//CDR ABC transporter//SNF2 family N-terminal domain//HAND//DNA-binding domain//DEAD/DEAH box helicase GO:0006508//GO:0043044//GO:0006810//GO:0006338 proteolysis//ATP-dependent chromatin remodeling//transport//chromatin remodeling GO:0003676//GO:0004197//GO:0003677//GO:0004386//GO:0031491//GO:0042626//GO:0016818//GO:0016787//GO:0005524 nucleic acid binding//cysteine-type endopeptidase activity//DNA binding//helicase activity//nucleosome binding//ATPase activity, coupled to transmembrane movement of substances//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrolase activity//ATP binding GO:0000785//GO:0005634//GO:0016021//GO:0016585 chromatin//nucleus//integral component of membrane//obsolete chromatin remodeling complex KOG0385 Chromatin remodeling complex WSTF-ISWI, small subunit Cluster-8309.31206 BF_2 1568.56 26.26 2786 189235208 XP_001808961.1 811 1.6e-83 PREDICTED: BTB/POZ domain-containing protein 2 [Tribolium castaneum]>gi|270003755|gb|EFA00203.1| hypothetical protein TcasGA2_TC003028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TZE1 140 4.3e-07 BTB/POZ domain-containing protein 6-B OS=Danio rerio GN=btbd6b PE=2 SV=1 PF15171 Neuropeptide secretory protein family, NPQ, spexin GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity -- -- -- -- Cluster-8309.31209 BF_2 353.68 10.43 1706 642923918 XP_969405.2 1124 5.1e-120 PREDICTED: serine/threonine-protein phosphatase 2A activator [Tribolium castaneum] 318037409 NM_001201142.1 54 7.34096e-17 Ictalurus punctatus serine/threonine-protein phosphatase 2a regulatory subunit b' (ptpa), mRNA >gnl|BL_ORD_ID|9527029 Ictalurus punctatus clone CBPN47522 serine/threonine-protein phosphatase 2a regulatory subunit b' (PTPA) mRNA, complete cds K17605 PPP2R4, PTPA serine/threonine-protein phosphatase 2A activator http://www.genome.jp/dbget-bin/www_bget?ko:K17605 Q2KJ44 899 2.6e-95 Serine/threonine-protein phosphatase 2A activator OS=Bos taurus GN=PPP2R4 PE=2 SV=1 PF03095 Phosphotyrosyl phosphate activator (PTPA) protein -- -- GO:0019211 phosphatase activator activity -- -- KOG2867 Phosphotyrosyl phosphatase activator Cluster-8309.31210 BF_2 183.25 4.65 1935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31213 BF_2 4.42 0.32 865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03069 Acetamidase/Formamidase family GO:0006807 nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides -- -- -- -- Cluster-8309.31215 BF_2 39.49 0.73 2553 332375851 AEE63066.1 1129 2.0e-120 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 P17439 807 1.8e-84 Glucosylceramidase OS=Mus musculus GN=Gba PE=1 SV=1 PF02055 O-Glycosyl hydrolase family 30 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.31216 BF_2 19.16 0.54 1763 91086851 XP_974311.1 638 1.2e-63 PREDICTED: vacuolar protein-sorting-associated protein 25 [Tribolium castaneum]>gi|270010461|gb|EFA06909.1| hypothetical protein TcasGA2_TC009858 [Tribolium castaneum] -- -- -- -- -- K12189 VPS25, EAP20 ESCRT-II complex subunit VPS25 http://www.genome.jp/dbget-bin/www_bget?ko:K12189 Q6NWF4 431 5.0e-41 Vacuolar protein-sorting-associated protein 25 OS=Danio rerio GN=vps25 PE=2 SV=2 PF07749 Endoplasmic reticulum protein ERp29, C-terminal domain -- -- -- -- GO:0005783 endoplasmic reticulum KOG4068 Uncharacterized conserved protein Cluster-8309.31217 BF_2 229.00 2.74 3786 270009782 EFA06230.1 221 5.8e-15 hypothetical protein TcasGA2_TC009079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.31218 BF_2 125.54 2.10 2788 189239253 XP_001807041.1 343 3.1e-29 PREDICTED: uncharacterized protein LOC100141764 [Tribolium castaneum]>gi|270010382|gb|EFA06830.1| hypothetical protein TcasGA2_TC009773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08299//PF15178//PF05028 Bacterial dnaA protein helix-turn-helix//Mitochondrial import receptor subunit TOM5 homolog//Poly (ADP-ribose) glycohydrolase (PARG) GO:0006275//GO:0006270//GO:0005975 regulation of DNA replication//DNA replication initiation//carbohydrate metabolic process GO:0005524//GO:0043565//GO:0004649 ATP binding//sequence-specific DNA binding//poly(ADP-ribose) glycohydrolase activity GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.31220 BF_2 93.45 9.56 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31222 BF_2 4.00 0.85 483 270297202 NP_001161902.1 680 4.4e-69 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 519 8.5e-52 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.31223 BF_2 24.16 0.34 3280 157126475 XP_001660898.1 773 4.9e-79 AAEL010538-PA [Aedes aegypti]>gi|108873249|gb|EAT37474.1| AAEL010538-PA [Aedes aegypti] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q9VU70 394 1.8e-36 Tetratricopeptide repeat protein 36 homolog OS=Drosophila melanogaster GN=CG14105 PE=1 SV=1 PF03169//PF05132//PF13181//PF03839//PF13414//PF13371//PF00515//PF13374 OPT oligopeptide transporter protein//RNA polymerase III RPC4//Tetratricopeptide repeat//Translocation protein Sec62//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006144//GO:0055085//GO:0006383//GO:0006351//GO:0015031//GO:0006206 purine nucleobase metabolic process//transmembrane transport//transcription from RNA polymerase III promoter//transcription, DNA-templated//protein transport//pyrimidine nucleobase metabolic process GO:0005515//GO:0003677//GO:0003899//GO:0008565 protein binding//DNA binding//DNA-directed RNA polymerase activity//protein transporter activity GO:0016021//GO:0005730//GO:0005666 integral component of membrane//nucleolus//DNA-directed RNA polymerase III complex KOG2927 Membrane component of ER protein translocation complex Cluster-8309.31224 BF_2 55.74 0.59 4222 478263721 ENN82024.1 902 7.0e-94 hypothetical protein YQE_01599, partial [Dendroctonus ponderosae]>gi|546679404|gb|ERL89875.1| hypothetical protein D910_07234, partial [Dendroctonus ponderosae] -- -- -- -- -- K00826 E2.6.1.42, ilvE branched-chain amino acid aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00826 A7SLW1 600 3.0e-60 Branched-chain-amino-acid aminotransferase OS=Nematostella vectensis GN=v1g246094 PE=3 SV=1 PF01063 Amino-transferase class IV GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0975 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily Cluster-8309.31228 BF_2 176.00 7.78 1233 189235480 XP_967613.2 643 2.2e-64 PREDICTED: nucleolar protein 16 [Tribolium castaneum]>gi|270003065|gb|EEZ99512.1| hypothetical protein TcasGA2_TC000093 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CPT5 297 1.2e-25 Nucleolar protein 16 OS=Mus musculus GN=Nop16 PE=2 SV=1 PF10176 Protein of unknown function (DUF2370) GO:0030001//GO:0007034 metal ion transport//vacuolar transport -- -- -- -- KOG4706 Uncharacterized conserved protein Cluster-8309.31229 BF_2 73.00 1.88 1914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.31230 BF_2 109.43 1.14 4301 642931657 XP_008196674.1 2456 4.5e-274 PREDICTED: rap1 GTPase-activating protein 1 isoform X3 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.40759e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 3.8e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF13851//PF07836//PF02145//PF02188 Growth-arrest specific micro-tubule binding//DmpG-like communication domain//Rap/ran-GAP//GoLoco motif GO:0048870//GO:0051056//GO:0019439 cell motility//regulation of small GTPase mediated signal transduction//aromatic compound catabolic process GO:0016833//GO:0005096//GO:0030695 oxo-acid-lyase activity//GTPase activator activity//GTPase regulator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.31231 BF_2 25.14 0.47 2514 91088273 XP_967838.1 497 3.8e-47 PREDICTED: protein scylla [Tribolium castaneum]>gi|270012158|gb|EFA08606.1| hypothetical protein TcasGA2_TC006266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTH4 254 2.4e-20 Protein scylla OS=Drosophila melanogaster GN=scyl PE=2 SV=1 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.31232 BF_2 333.21 12.25 1425 642922280 XP_008193091.1 142 3.2e-06 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31233 BF_2 99.88 2.43 2004 642922278 XP_008193090.1 283 2.0e-22 PREDICTED: UPF0544 protein C5orf45 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32PP1 197 7.7e-14 UPF0544 protein C5orf45 homolog OS=Danio rerio GN=zgc:123335 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31234 BF_2 75.65 0.44 7468 642915750 XP_008190789.1 4116 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 768311758 CP010986.1 610 0 Verticillium dahliae VdLs.17 chromosome 7, complete sequence K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 2.0e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.31235 BF_2 168.72 2.81 2802 546676927 ERL87851.1 1793 2.2e-197 hypothetical protein D910_05239 [Dendroctonus ponderosae] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.9e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.31237 BF_2 426.54 8.80 2314 91090858 XP_967143.1 1222 3.0e-131 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 912 1.1e-96 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.31238 BF_2 24.00 6.59 439 4506605 NP_000969.1 610 5.3e-61 60S ribosomal protein L23 [Homo sapiens]>gi|12584986|ref|NP_075029.1| 60S ribosomal protein L23 [Mus musculus]>gi|56090279|ref|NP_001007600.1| 60S ribosomal protein L23 [Rattus norvegicus]>gi|58332166|ref|NP_001011231.1| 60S ribosomal protein L23 [Xenopus (Silurana) tropicalis]>gi|194018720|ref|NP_001123427.1| 60S ribosomal protein L23 [Sus scrofa]>gi|318760126|ref|NP_001187049.1| 60S ribosomal protein L23 [Ictalurus punctatus]>gi|388490440|ref|NP_001253138.1| 60S ribosomal protein L23 [Macaca mulatta]>gi|756140997|ref|NP_001291852.1| ribosomal protein L23 [Ailuropoda melanoleuca]>gi|114667757|ref|XP_511444.2| PREDICTED: 60S ribosomal protein L23 [Pan troglodytes]>gi|126308182|ref|XP_001366590.1| PREDICTED: 60S ribosomal protein L23 [Monodelphis domestica]>gi|296202685|ref|XP_002748553.1| PREDICTED: 60S ribosomal protein L23 [Callithrix jacchus]>gi|327275650|ref|XP_003222586.1| PREDICTED: 60S ribosomal protein L23 [Anolis carolinensis]>gi|332258346|ref|XP_003278259.1| PREDICTED: 60S ribosomal protein L23 [Nomascus leucogenys]>gi|332258358|ref|XP_003278265.1| PREDICTED: 60S ribosomal protein L23 [Nomascus leucogenys]>gi|338710897|ref|XP_003362441.1| PREDICTED: 60S ribosomal protein L23 [Equus caballus]>gi|344285963|ref|XP_003414729.1| PREDICTED: 60S ribosomal protein L23 [Loxodonta africana]>gi|345319092|ref|XP_001509789.2| PREDICTED: 60S ribosomal protein L23 [Ornithorhynchus anatinus]>gi|348517843|ref|XP_003446442.1| PREDICTED: 60S ribosomal protein L23-like [Oreochromis niloticus]>gi|348562313|ref|XP_003466955.1| PREDICTED: 60S ribosomal protein L23 [Cavia porcellus]>gi|354474813|ref|XP_003499624.1| PREDICTED: 60S ribosomal protein L23 [Cricetulus griseus]>gi|363743473|ref|XP_418122.3| PREDICTED: 60S ribosomal protein L23 isoformX2 [Gallus gallus]>gi|377837128|ref|XP_003688806.1| PREDICTED: 60S ribosomal protein L23 [Mus musculus]>gi|377837258|ref|XP_003689266.1| PREDICTED: 60S ribosomal protein L23 isoform X2 [Mus musculus]>gi|395532530|ref|XP_003768323.1| PREDICTED: 60S ribosomal protein L23 [Sarcophilus harrisii]>gi|395826550|ref|XP_003786480.1| PREDICTED: 60S ribosomal protein L23 [Otolemur garnettii]>gi|397477028|ref|XP_003809888.1| PREDICTED: 60S ribosomal protein L23 [Pan paniscus]>gi|402855371|ref|XP_003892299.1| PREDICTED: 60S ribosomal protein L23 [Papio anubis]>gi|402899985|ref|XP_003912963.1| PREDICTED: 60S ribosomal protein L23 [Papio anubis]>gi|410980905|ref|XP_003996814.1| PREDICTED: 60S ribosomal protein L23 [Felis catus]>gi|426348537|ref|XP_004041890.1| PREDICTED: 60S ribosomal protein L23 [Gorilla gorilla gorilla]>gi|432960814|ref|XP_004086478.1| PREDICTED: 60S ribosomal protein L23 [Oryzias latipes]>gi|471380551|ref|XP_004378071.1| PREDICTED: 60S ribosomal protein L23 [Trichechus manatus latirostris]>gi|472350883|ref|XP_004395126.1| PREDICTED: 60S ribosomal protein L23 [Odobenus rosmarus divergens]>gi|478520865|ref|XP_004434646.1| PREDICTED: 60S ribosomal protein L23 [Ceratotherium simum simum]>gi|488526322|ref|XP_004454995.1| PREDICTED: 60S ribosomal protein L23 [Dasypus novemcinctus]>gi|499035979|ref|XP_004568658.1| PREDICTED: 60S ribosomal protein L23 [Maylandia zebra]>gi|504159898|ref|XP_004591186.1| PREDICTED: 60S ribosomal protein L23 [Ochotona princeps]>gi|505802875|ref|XP_004608777.1| PREDICTED: 60S ribosomal protein L23 [Sorex araneus]>gi|507543109|ref|XP_004655546.1| PREDICTED: 60S ribosomal protein L23 [Jaculus jaculus]>gi|507664755|ref|XP_004707161.1| PREDICTED: 60S ribosomal protein L23 [Echinops telfairi]>gi|507952684|ref|XP_004684321.1| PREDICTED: 60S ribosomal protein L23 [Condylura cristata]>gi|511890070|ref|XP_004764745.1| PREDICTED: 60S ribosomal protein L23 [Mustela putorius furo]>gi|512995994|ref|XP_004859587.1| PREDICTED: 60S ribosomal protein L23 [Heterocephalus glaber]>gi|524951944|ref|XP_005075973.1| PREDICTED: 60S ribosomal protein L23 [Mesocricetus auratus]>gi|527244975|ref|XP_005140830.1| PREDICTED: 60S ribosomal protein L23 [Melopsittacus undulatus]>gi|530624681|ref|XP_005301894.1| PREDICTED: 60S ribosomal protein L23 [Chrysemys picta bellii]>gi|532071999|ref|XP_005321819.1| PREDICTED: 60S ribosomal protein L23 [Ictidomys tridecemlineatus]>gi|533160995|ref|XP_005394345.1| PREDICTED: 60S ribosomal protein L23 [Chinchilla lanigera]>gi|543376513|ref|XP_005531465.1| PREDICTED: 60S ribosomal protein L23 [Pseudopodoces humilis]>gi|543734608|ref|XP_005508298.1| PREDICTED: 60S ribosomal protein L23 [Columba livia]>gi|548539238|ref|XP_005752845.1| PREDICTED: 60S ribosomal protein L23-like [Pundamilia nyererei]>gi|551531771|ref|XP_005817333.1| PREDICTED: 60S ribosomal protein L23-like [Xiphophorus maculatus]>gi|554880449|ref|XP_005950010.1| PREDICTED: 60S ribosomal protein L23-like [Haplochromis burtoni]>gi|555972075|ref|XP_005898045.1| PREDICTED: 60S ribosomal protein L23 [Bos mutus]>gi|556738430|ref|XP_005964788.1| PREDICTED: 60S ribosomal protein L23 [Pantholops hodgsonii]>gi|557279173|ref|XP_006022629.1| PREDICTED: 60S ribosomal protein L23 [Alligator sinensis]>gi|558215710|ref|XP_006108626.1| PREDICTED: 60S ribosomal protein L23-like [Myotis lucifugus]>gi|560900027|ref|XP_006176435.1| PREDICTED: 60S ribosomal protein L23 [Camelus ferus]>gi|560984157|ref|XP_006214292.1| PREDICTED: 60S ribosomal protein L23 [Vicugna pacos]>gi|562854662|ref|XP_006155929.1| PREDICTED: 60S ribosomal protein L23 [Tupaia chinensis]>gi|564236289|ref|XP_006275052.1| PREDICTED: 60S ribosomal protein L23 [Alligator mississippiensis]>gi|573901345|ref|XP_006638399.1| PREDICTED: 60S ribosomal protein L23-like [Lepisosteus oculatus]>gi|584023253|ref|XP_006806271.1| PREDICTED: 60S ribosomal protein L23-like [Neolamprologus brichardi]>gi|584059750|ref|XP_006774353.1| PREDICTED: 60S ribosomal protein L23 [Myotis davidii]>gi|585183569|ref|XP_006743370.1| PREDICTED: 60S ribosomal protein L23 [Leptonychotes weddellii]>gi|585671995|ref|XP_006889432.1| PREDICTED: 60S ribosomal protein L23 [Elephantulus edwardii]>gi|586448839|ref|XP_006832600.1| PREDICTED: 60S ribosomal protein L23 [Chrysochloris asiatica]>gi|586539893|ref|XP_006924783.1| PREDICTED: 60S ribosomal protein L23 [Pteropus alecto]>gi|589917216|ref|XP_006971922.1| PREDICTED: 60S ribosomal protein L23 [Peromyscus maniculatus bairdii]>gi|591319181|ref|XP_007085828.1| PREDICTED: 60S ribosomal protein L23 [Panthera tigris altaica]>gi|591374654|ref|XP_007062013.1| PREDICTED: 60S ribosomal protein L23 [Chelonia mydas]>gi|593734344|ref|XP_007112625.1| PREDICTED: 60S ribosomal protein L23 [Physeter catodon]>gi|594042833|ref|XP_006045943.1| PREDICTED: 60S ribosomal protein L23 [Bubalus bubalis]>gi|594658549|ref|XP_007177585.1| PREDICTED: 60S ribosomal protein L23 [Balaenoptera acutorostrata scammoni]>gi|602646944|ref|XP_007429902.1| PREDICTED: 60S ribosomal protein L23 [Python bivittatus]>gi|602709914|ref|XP_007465209.1| PREDICTED: 60S ribosomal protein L23 [Lipotes vexillifer]>gi|617471823|ref|XP_007575658.1| PREDICTED: 60S ribosomal protein L23 [Poecilia formosa]>gi|617524455|ref|XP_007544921.1| PREDICTED: 60S ribosomal protein L23 [Poecilia formosa]>gi|617637767|ref|XP_007530989.1| PREDICTED: 60S ribosomal protein L23 [Erinaceus europaeus]>gi|625248473|ref|XP_007615524.1| PREDICTED: 60S ribosomal protein L23 [Cricetulus griseus]>gi|634851396|ref|XP_007940203.1| PREDICTED: 60S ribosomal protein L23 [Orycteropus afer afer]>gi|640813814|ref|XP_008063617.1| PREDICTED: 60S ribosomal protein L23 [Tarsius syrichta]>gi|641724256|ref|XP_008152011.1| PREDICTED: 60S ribosomal protein L23 [Eptesicus fuscus]>gi|657596416|ref|XP_008302910.1| PREDICTED: 60S ribosomal protein L23 [Stegastes partitus]>gi|657803419|ref|XP_008328798.1| PREDICTED: 60S ribosomal protein L23 [Cynoglossus semilaevis]>gi|658861016|ref|XP_008413270.1| PREDICTED: 60S ribosomal protein L23 [Poecilia reticulata]>gi|664728631|ref|XP_008521501.1| PREDICTED: 60S ribosomal protein L23 [Equus przewalskii]>gi|670977783|ref|XP_008687238.1| PREDICTED: 60S ribosomal protein L23 [Ursus maritimus]>gi|674072617|ref|XP_008843500.1| PREDICTED: 60S ribosomal protein L23 [Nannospalax galili]>gi|699674330|ref|XP_009885393.1| PREDICTED: 60S ribosomal protein L23 [Charadrius vociferus]>gi|724903239|ref|XP_010377635.1| PREDICTED: 60S ribosomal protein L23 [Rhinopithecus roxellana]>gi|729725815|ref|XP_010583836.1| PREDICTED: 60S ribosomal protein L23 [Haliaeetus leucocephalus]>gi|734629155|ref|XP_010742852.1| PREDICTED: 60S ribosomal protein L23 [Larimichthys crocea]>gi|742135727|ref|XP_010840991.1| PREDICTED: 60S ribosomal protein L23 [Bison bison bison]>gi|742149732|ref|XP_010844046.1| PREDICTED: 60S ribosomal protein L23 [Bison bison bison]>gi|743729410|ref|XP_010958797.1| PREDICTED: 60S ribosomal protein L23 [Camelus bactrianus]>gi|744599820|ref|XP_010990145.1| PREDICTED: 60S ribosomal protein L23 [Camelus dromedarius]>gi|759190308|ref|XP_011382607.1| PREDICTED: 60S ribosomal protein L23 [Pteropus vampyrus]>gi|768393400|ref|XP_011592359.1| PREDICTED: 60S ribosomal protein L23 [Aquila chrysaetos canadensis]>gi|795158697|ref|XP_011840103.1| PREDICTED: 60S ribosomal protein L23 [Mandrillus leucophaeus]>gi|795295577|ref|XP_011815217.1| PREDICTED: 60S ribosomal protein L23 [Colobus angolensis palliatus]>gi|795295584|ref|XP_011815218.1| PREDICTED: 60S ribosomal protein L23 [Colobus angolensis palliatus]>gi|795526735|ref|XP_011901790.1| PREDICTED: 60S ribosomal protein L23 isoform X2 [Cercocebus atys]>gi|795582893|ref|XP_011723658.1| PREDICTED: 60S ribosomal protein L23 [Macaca nemestrina]>gi|803120744|ref|XP_012041406.1| PREDICTED: 60S ribosomal protein L23 [Ovis aries]>gi|803275253|ref|XP_011997302.1| PREDICTED: 60S ribosomal protein L23 [Ovis aries musimon]>gi|817274545|ref|XP_012307344.1| PREDICTED: 60S ribosomal protein L23 [Aotus nancymaae]>gi|826272564|ref|XP_012517968.1| PREDICTED: 60S ribosomal protein L23 [Propithecus coquereli]>gi|826293327|ref|XP_012499631.1| PREDICTED: 60S ribosomal protein L23 [Propithecus coquereli]>gi|829772259|ref|XP_012621394.1| PREDICTED: 60S ribosomal protein L23 [Microcebus murinus]>gi|852733226|ref|XP_012893563.1| PREDICTED: 60S ribosomal protein L23 [Dipodomys ordii]>gi|46577102|sp|Q90YU5.2|RL23_ICTPU RecName: Full=60S ribosomal protein L23 [Ictalurus punctatus]>gi|51338616|sp|P62831.1|RL23_PIG RecName: Full=60S ribosomal protein L23; AltName: Full=Ribosomal protein L17>gi|51338617|sp|P62832.1|RL23_RAT RecName: Full=60S ribosomal protein L23>gi|51338639|sp|P62829.1|RL23_HUMAN RecName: Full=60S ribosomal protein L23; AltName: Full=60S ribosomal protein L17>gi|51338640|sp|P62830.1|RL23_MOUSE RecName: Full=60S ribosomal protein L23>gi|190356062|sp|Q3T057.2|RL23_BOVIN RecName: Full=60S ribosomal protein L23>gi|187609309|pdb|2ZKR|KK Chain k, Structure Of A Mammalian Ribosomal 60s Subunit Within An 80s Complex Obtained By Docking Homology Models Of The Rna And Proteins Into An 8.7 A Cryo-em Map>gi|485601426|pdb|3J3B|V Chain V, Structure Of The Human 60s Ribosomal Proteins>gi|665764279|pdb|4CXD|V Chain V, Regulation Of The Mammalian Elongation Cycle By 40s Subunit Rolling: A Eukaryotic-specific Ribosome Rearrangement>gi|672884396|pdb|4UPX|V Chain V, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Pre-like State>gi|672884448|pdb|4UQ1|V Chain V, Mammalian 80s Hcv-ires Initiation Complex With Eif5b Post-like State>gi|675970148|pdb|4W20|V Chain V, Structure Of The Mammalian 60s Ribosomal Subunit (this Entry Contains The Large Ribosomal Proteins)>gi|675970199|pdb|4W22|V Chain V, Structure Of The 80s Mammalian Ribosome Bound To Eef2 (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970290|pdb|4W25|V Chain V, Structure Of The Idle Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|675970343|pdb|4W27|V Chain V, Structure Of The Translating Mammalian Ribosome-sec61 Complex (this Entry Contains The Large Ribosomal Subunit Proteins)>gi|5354205|gb|AAD42413.1|AF158022_1 ribosomal protein L23 [Mus musculus]>gi|9502282|gb|AAF88071.1|AF287271_1 ribosomal protein L23 [Mus musculus]>gi|24762286|gb|AAK95149.2|AF401577_1 ribosomal protein L23 [Ictalurus punctatus]>gi|34194|emb|CAA39417.1| HL23 ribosomal protein [Homo sapiens]>gi|36126|emb|CAA37023.1| ribosomal protein L17 [Homo sapiens]>gi|57688|emb|CAA41177.1| ribosomal protein L23 [Rattus rattus]>gi|12846298|dbj|BAB27112.1| unnamed protein product [Mus musculus]>gi|12858591|dbj|BAB31373.1| unnamed protein product [Mus musculus]>gi|14603313|gb|AAH10114.1| Ribosomal protein L23 [Homo sapiens]>gi|17932948|dbj|BAB79465.1| ribosomal protein L23 [Homo sapiens]>gi|19484155|gb|AAH25918.1| Ribosomal protein L23 [Mus musculus]>gi|37231757|gb|AAH58500.1| Ribosomal protein L23 [Rattus norvegicus]>gi|51980397|gb|AAH81448.1| Ribosomal protein L23 [Mus musculus]>gi|56611168|gb|AAH87796.1| ribosomal protein L23 [Xenopus (Silurana) tropicalis]>gi|74177908|dbj|BAE29753.1| unnamed protein product [Mus musculus]>gi|74207716|dbj|BAE40102.1| unnamed protein product [Mus musculus]>gi|74356227|gb|AAI04652.1| Ribosomal protein L23 [Homo sapiens]>gi|76780073|gb|AAI06062.1| RPL23 protein [Homo sapiens]>gi|89268196|emb|CAJ82654.1| ribosomal protein L23 [Xenopus (Silurana) tropicalis]>gi|117661026|gb|ABK55650.1| RPL23 [Sus scrofa]>gi|119580944|gb|EAW60540.1| ribosomal protein L23, isoform CRA_b [Homo sapiens]>gi|119580945|gb|EAW60541.1| ribosomal protein L23, isoform CRA_b [Homo sapiens]>gi|123993085|gb|ABM84144.1| ribosomal protein L23 [synthetic construct]>gi|124000075|gb|ABM87546.1| ribosomal protein L23 [synthetic construct]>gi|148684153|gb|EDL16100.1| ribosomal protein L23, isoform CRA_b [Mus musculus]>gi|149054067|gb|EDM05884.1| rCG34264, isoform CRA_b [Rattus norvegicus]>gi|151556408|gb|AAI48015.1| Ribosomal protein L23 [Bos taurus]>gi|164690981|dbj|BAF98673.1| ribosomal protein L23 [Solea senegalensis]>gi|206558008|gb|ACI12870.1| ribosomal protein L23 [Gillichthys mirabilis]>gi|261860426|dbj|BAI46735.1| ribosomal protein L23 [synthetic construct]>gi|296476465|tpg|DAA18580.1| TPA: 60S ribosomal protein L23 [Bos taurus]>gi|327239298|gb|AEA39516.1| ribosomal protein L23 [Ailuropoda melanoleuca]>gi|327239400|gb|AEA39567.1| ribosomal protein L23 [Ailuropoda melanoleuca]>gi|344249178|gb|EGW05282.1| 60S ribosomal protein L23 [Cricetulus griseus]>gi|351706759|gb|EHB09678.1| 60S ribosomal protein L23 [Heterocephalus glaber]>gi|444713983|gb|ELW54871.1| 60S ribosomal protein L23 [Tupaia chinensis]>gi|465974411|gb|EMP33812.1| 60S ribosomal protein L23 [Chelonia mydas]>gi|649105273|gb|AIC50337.1| RPL23, partial [synthetic construct]>gi|808848118|gb|KKF09104.1| 60S ribosomal protein L23 [Larimichthys crocea] 694833446 XM_009475846.1 159 7.62775e-76 PREDICTED: Nipponia nippon ribosomal protein L23 (RPL23), mRNA K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P62832 610 2.2e-62 60S ribosomal protein L23 OS=Rattus norvegicus GN=Rpl23 PE=2 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0042254//GO:0006415//GO:0006413//GO:0000184//GO:0006412//GO:0006414//GO:0006614//GO:0006610//GO:0019083 ribosome biogenesis//translational termination//translational initiation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//translation//translational elongation//SRP-dependent cotranslational protein targeting to membrane//ribosomal protein import into nucleus//viral transcription GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005730//GO:0005840//GO:0022625 nucleolus//ribosome//cytosolic large ribosomal subunit KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.31239 BF_2 137.40 4.90 1459 443725752 ELU13203.1 1077 1.2e-114 hypothetical protein CAPTEDRAFT_149382 [Capitella teleta] -- -- -- -- -- K01805 xylA xylose isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01805 Q9FKK7 810 4.6e-85 Xylose isomerase OS=Arabidopsis thaliana GN=XYLA PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31243 BF_2 95.02 8.86 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31245 BF_2 242.44 7.99 1556 -- -- -- -- -- 642928448 XM_008195568.1 132 2.91705e-60 PREDICTED: Tribolium castaneum transcriptional-regulating factor 1 (LOC103313127), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31250 BF_2 568.00 14.19 1962 642940045 XP_972775.2 1228 5.1e-132 PREDICTED: ankyrin repeat and MYND domain-containing protein 2 [Tribolium castaneum]>gi|270015900|gb|EFA12348.1| hypothetical protein TcasGA2_TC004088 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMD2 678 1.3e-69 Ankyrin repeat and MYND domain-containing protein 2 OS=Gallus gallus GN=ANKMY2 PE=2 SV=1 PF13597//PF13606//PF00023 Anaerobic ribonucleoside-triphosphate reductase//Ankyrin repeat//Ankyrin repeat GO:0055114//GO:0006206//GO:0006260 oxidation-reduction process//pyrimidine nucleobase metabolic process//DNA replication GO:0016491//GO:0005515//GO:0043169//GO:0008998 oxidoreductase activity//protein binding//cation binding//ribonucleoside-triphosphate reductase activity -- -- KOG1710 MYND Zn-finger and ankyrin repeat protein Cluster-8309.31254 BF_2 333.29 2.26 6449 91085823 XP_974821.1 3077 0.0e+00 PREDICTED: bone morphogenetic protein receptor type-2 [Tribolium castaneum]>gi|270011027|gb|EFA07475.1| wishful thinking [Tribolium castaneum] -- -- -- -- -- K04671 BMPR2 bone morphogenetic protein receptor type-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04671 O35607 801 2.3e-83 Bone morphogenetic protein receptor type-2 OS=Mus musculus GN=Bmpr2 PE=1 SV=1 PF03829//PF06221//PF07714//PF00069//PF01064//PF03460 PTS system glucitol/sorbitol-specific IIA component//Putative zinc finger motif, C2HC5-type//Protein tyrosine kinase//Protein kinase domain//Activin types I and II receptor domain//Nitrite/Sulfite reductase ferredoxin-like half domain GO:0016310//GO:0008643//GO:0023014//GO:0009069//GO:0006468//GO:0007178//GO:0055114//GO:0006355//GO:0009401 phosphorylation//carbohydrate transport//signal transduction by protein phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//oxidation-reduction process//regulation of transcription, DNA-templated//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0016491//GO:0004672//GO:0005024//GO:0008982//GO:0004675//GO:0004702//GO:0005524//GO:0008270 oxidoreductase activity//protein kinase activity//transforming growth factor beta-activated receptor activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//transmembrane receptor protein serine/threonine kinase activity//receptor signaling protein serine/threonine kinase activity//ATP binding//zinc ion binding GO:0005634//GO:0016020//GO:0005737//GO:0009357 nucleus//membrane//cytoplasm//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.31255 BF_2 574.66 8.02 3284 91086089 XP_967008.1 1467 1.7e-159 PREDICTED: XK-related protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q49LS8 310 9.9e-27 XK-related protein 6 OS=Tetraodon nigroviridis GN=xkr6 PE=2 SV=1 PF03694//PF09815 Erg28 like protein//XK-related protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31256 BF_2 139.00 7.07 1110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31260 BF_2 98.00 1.26 3532 642933227 XP_008197316.1 2898 0.0e+00 PREDICTED: uncharacterized protein LOC103314106 [Tribolium castaneum]>gi|270011449|gb|EFA07897.1| hypothetical protein TcasGA2_TC005472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31263 BF_2 1292.38 6.35 8801 478262399 ENN81070.1 2351 1.4e-261 hypothetical protein YQE_02439, partial [Dendroctonus ponderosae]>gi|546673619|gb|ERL85183.1| hypothetical protein D910_02605 [Dendroctonus ponderosae] 830109730 XM_012729993.1 95 6.21486e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1140 1.5e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.31264 BF_2 53.72 1.35 1954 642915929 XP_008190815.1 330 6.9e-28 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050//PF01920//PF02895//PF01025//PF10473//PF05531//PF03938 Flagellar FliJ protein//Prefoldin subunit//Signal transducing histidine kinase, homodimeric domain//GrpE//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Nucleopolyhedrovirus P10 protein//Outer membrane protein (OmpH-like) GO:0000160//GO:0006457//GO:0006935//GO:0071973//GO:0016310 phosphorelay signal transduction system//protein folding//chemotaxis//bacterial-type flagellum-dependent cell motility//phosphorylation GO:0051087//GO:0051082//GO:0004673//GO:0000774//GO:0000155//GO:0008134//GO:0045502//GO:0042803//GO:0003774 chaperone binding//unfolded protein binding//protein histidine kinase activity//adenyl-nucleotide exchange factor activity//phosphorelay sensor kinase activity//transcription factor binding//dynein binding//protein homodimerization activity//motor activity GO:0009288//GO:0005737//GO:0016272//GO:0019028//GO:0016020//GO:0030286//GO:0005667//GO:0009365 bacterial-type flagellum//cytoplasm//prefoldin complex//viral capsid//membrane//dynein complex//transcription factor complex//protein histidine kinase complex -- -- Cluster-8309.31265 BF_2 74.00 2.19 1700 91083889 XP_974460.1 1221 2.9e-131 PREDICTED: UPF0553 protein C9orf64 homolog [Tribolium castaneum]>gi|270006749|gb|EFA03197.1| hypothetical protein TcasGA2_TC013117 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1JP73 727 2.3e-75 UPF0553 protein C9orf64 homolog OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2524 Cobyrinic acid a,c-diamide synthase Cluster-8309.31266 BF_2 299.17 13.82 1193 91077852 XP_971951.1 372 5.7e-33 PREDICTED: uncharacterized protein LOC660645 [Tribolium castaneum]>gi|270002261|gb|EEZ98708.1| hypothetical protein TcasGA2_TC001249 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06910 Male enhanced antigen 1 (MEA1) GO:0007283 spermatogenesis -- -- -- -- -- -- Cluster-8309.31267 BF_2 160.57 5.34 1544 546680604 ERL90847.1 772 3.0e-79 hypothetical protein D910_08192 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8GXK5 203 1.2e-14 Sugar transporter ERD6-like 14 OS=Arabidopsis thaliana GN=At4g04750 PE=2 SV=2 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.31269 BF_2 76.25 3.49 1202 642919747 XP_008192048.1 231 1.3e-16 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31270 BF_2 1.00 1.19 309 270004868 EFA01316.1 209 1.2e-14 hypothetical protein TcasGA2_TC003278 [Tribolium castaneum] -- -- -- -- -- K05465 ANGPT1 angiopoietin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05465 Q9WVH6 162 1.3e-10 Angiopoietin-4 OS=Mus musculus GN=Angpt4 PE=1 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- -- -- Cluster-8309.31271 BF_2 64.98 1.67 1912 189234413 XP_975276.2 833 3.2e-86 PREDICTED: uncharacterized protein LOC664170 isoform X1 [Tribolium castaneum] 642913234 XM_008203228.1 83 6.24065e-33 PREDICTED: Tribolium castaneum uncharacterized LOC664170 (LOC664170), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31273 BF_2 203.07 14.26 883 270001970 EEZ98417.1 662 9.9e-67 hypothetical protein TcasGA2_TC000885 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31276 BF_2 165.30 10.32 957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31277 BF_2 1242.26 35.77 1740 642939867 XP_969882.2 2279 6.1e-254 PREDICTED: alpha-aminoadipic semialdehyde dehydrogenase [Tribolium castaneum] -- -- -- -- -- K14085 ALDH7A1 aldehyde dehydrogenase family 7 member A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14085 Q2KJC9 1753 2.5e-194 Alpha-aminoadipic semialdehyde dehydrogenase OS=Bos taurus GN=ALDH7A1 PE=2 SV=4 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.31279 BF_2 526.46 7.81 3106 270003083 EEZ99530.1 2513 8.1e-281 hypothetical protein TcasGA2_TC000112 [Tribolium castaneum] -- -- -- -- -- K13117 DHX35 ATP-dependent RNA helicase DDX35 http://www.genome.jp/dbget-bin/www_bget?ko:K13117 Q9H5Z1 1590 3.5e-175 Probable ATP-dependent RNA helicase DHX35 OS=Homo sapiens GN=DHX35 PE=1 SV=2 PF04408//PF00400//PF01436 Helicase associated domain (HA2)//WD domain, G-beta repeat//NHL repeat -- -- GO:0005515//GO:0004386 protein binding//helicase activity -- -- KOG0922 DEAH-box RNA helicase Cluster-8309.31280 BF_2 185.77 4.54 1997 642911571 XP_008199480.1 1995 6.0e-221 PREDICTED: solute carrier family 41 member 1-like [Tribolium castaneum] 642911570 XM_008201258.1 432 0 PREDICTED: Tribolium castaneum solute carrier family 41 member 1-like (LOC662863), mRNA K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1136 1.0e-122 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF04093 Divalent cation transporter//rod shape-determining protein MreD GO:0008360//GO:0006812 regulation of cell shape//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG3788 Predicted divalent cation transporter Cluster-8309.31281 BF_2 138.00 32.41 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.31282 BF_2 274.65 13.21 1157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31283 BF_2 7.05 0.35 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31285 BF_2 129.32 2.77 2237 91085939 XP_970530.1 645 2.3e-64 PREDICTED: longitudinals lacking protein-like [Tribolium castaneum]>gi|270010169|gb|EFA06617.1| hypothetical protein TcasGA2_TC009535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 601 1.2e-60 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31287 BF_2 1173.00 31.91 1825 91076154 XP_970766.1 1141 5.9e-122 PREDICTED: venom protease [Tribolium castaneum]>gi|270015133|gb|EFA11581.1| serine protease P55 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5U2W0 758 6.2e-79 Venom serine protease Bi-VSP OS=Bombus ignitus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008236 serine-type endopeptidase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.31290 BF_2 39.00 3.63 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31291 BF_2 17.99 1.08 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31292 BF_2 303.34 5.81 2472 546685044 ERL94598.1 1467 1.3e-159 hypothetical protein D910_11875 [Dendroctonus ponderosae] 768419811 XM_011552337.1 173 7.54912e-83 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P06801 1037 3.7e-111 NADP-dependent malic enzyme OS=Mus musculus GN=Me1 PE=1 SV=2 PF00390//PF03949//PF01420 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain//Type I restriction modification DNA specificity domain GO:0006090//GO:0006099//GO:0015976//GO:0006108//GO:0006304//GO:0055114 pyruvate metabolic process//tricarboxylic acid cycle//carbon utilization//malate metabolic process//DNA modification//oxidation-reduction process GO:0003677//GO:0051287//GO:0004471 DNA binding//NAD binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.31294 BF_2 581.08 12.99 2158 91089627 XP_973479.1 2276 1.7e-253 PREDICTED: histone-binding protein RBBP4 [Tribolium castaneum]>gi|270012612|gb|EFA09060.1| hypothetical protein TcasGA2_TC006775 [Tribolium castaneum] 820847485 XM_003693377.2 567 0 PREDICTED: Apis florea probable histone-binding protein Caf1 (LOC100871885), mRNA K10752 RBBP4, HAT2, CAF1, MIS16 histone-binding protein RBBP4 http://www.genome.jp/dbget-bin/www_bget?ko:K10752 Q24572 2179 1.2e-243 Probable histone-binding protein Caf1 OS=Drosophila melanogaster GN=Caf1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding GO:0005634 nucleus KOG0264 Nucleosome remodeling factor, subunit CAF1/NURF55/MSI1 Cluster-8309.31296 BF_2 50.52 1.62 1594 189234066 XP_970272.2 1824 3.2e-201 PREDICTED: calcium uptake protein 3, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CD10 707 4.4e-73 Calcium uptake protein 2, mitochondrial OS=Mus musculus GN=Micu2 PE=1 SV=2 PF12763//PF13202//PF13499//PF00036//PF13405//PF13833 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.31297 BF_2 179.00 1.83 4371 270009864 EFA06312.1 3062 0.0e+00 hypothetical protein TcasGA2_TC009181 [Tribolium castaneum] 755980909 XM_011311102.1 314 5.57732e-161 PREDICTED: Fopius arisanus neuroendocrine convertase 2 (LOC105270270), mRNA K01360 PCSK2 proprotein convertase subtilisin/kexin type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K01360 P28841 1959 8.1e-218 Neuroendocrine convertase 2 OS=Rattus norvegicus GN=Pcsk2 PE=1 SV=1 PF01483//PF00082 Proprotein convertase P-domain//Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3526 Subtilisin-like proprotein convertase Cluster-8309.31298 BF_2 99.70 1.97 2399 332372937 AEE61610.1 1260 1.2e-135 unknown [Dendroctonus ponderosae]>gi|546684868|gb|ERL94450.1| hypothetical protein D910_11727 [Dendroctonus ponderosae] 758277713 KP113812.1 111 2.13943e-48 Acraea encedon voucher fj55_3 cytosolic malate dehydrogenase (Cmdh) gene, partial cds K00025 MDH1 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00025 Q5ZME2 1033 1.1e-110 Malate dehydrogenase, cytoplasmic OS=Gallus gallus GN=MDH1 PE=2 SV=1 PF00056//PF02866 lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114 oxidation-reduction process GO:0016616//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1496 Malate dehydrogenase Cluster-8309.31299 BF_2 413.73 12.65 1655 91090526 XP_970144.1 693 4.7e-70 PREDICTED: UBX domain-containing protein 1 [Tribolium castaneum]>gi|270013875|gb|EFA10323.1| hypothetical protein TcasGA2_TC012540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GL77 271 1.7e-22 UBX domain-containing protein 1 OS=Xenopus tropicalis GN=ubxn1 PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG2689 Predicted ubiquitin regulatory protein Cluster-8309.31300 BF_2 25.26 1.01 1334 642917749 XP_008191355.1 1095 9.2e-117 PREDICTED: exonuclease mut-7 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N9H8 421 5.4e-40 Exonuclease mut-7 homolog OS=Homo sapiens GN=EXD3 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2207 Predicted 3'-5' exonuclease Cluster-8309.31304 BF_2 132.13 1.10 5329 270005044 EFA01492.1 6586 0.0e+00 hypothetical protein TcasGA2_TC007046 [Tribolium castaneum] 884965815 XM_010892944.2 162 2.13537e-76 PREDICTED: Esox lucius HECT domain containing E3 ubiquitin protein ligase 1 (hectd1), transcript variant X6, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 4691 0.0e+00 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF00023//PF13606//PF06701 Ankyrin repeat//Ankyrin repeat//Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872 ubiquitin-protein transferase activity//protein binding//metal ion binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.31307 BF_2 62.22 1.26 2357 91084421 XP_968215.1 911 3.5e-95 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 P35502 652 1.6e-66 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06467//PF07425//PF00326//PF07859 MYM-type Zinc finger with FCS sequence motif//Pardaxin//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0008270//GO:0016787 serine-type peptidase activity//zinc ion binding//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.31308 BF_2 21.30 0.54 1950 189238236 XP_972123.2 193 5.3e-12 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Tribolium castaneum]>gi|270008671|gb|EFA05119.1| hypothetical protein TcasGA2_TC015232 [Tribolium castaneum] 743280388 KM065747.1 90 8.17816e-37 Culex quinquefasciatus clone C2B G-protein gamma-subunit mRNA, complete cds K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ2 179 9.1e-12 Guanine nucleotide-binding protein subunit gamma-e OS=Calliphora vicina PE=3 SV=1 PF00631 GGL domain GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-8309.31309 BF_2 213.17 1.08 8510 86515334 NP_001034492.1 4335 0.0e+00 chitin synthase 2 [Tribolium castaneum]>gi|33867321|gb|AAQ55061.1| chitin synthase CHS2 [Tribolium castaneum]>gi|34148365|gb|AAQ62692.1| chitin synthase [Tribolium castaneum]>gi|270014271|gb|EFA10719.1| chitin synthase 2 [Tribolium castaneum] -- -- -- -- -- K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q9H3F6 946 4.6e-100 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens GN=KCTD10 PE=1 SV=1 PF03233//PF02214//PF02186//PF00651 Aphid transmission protein//BTB/POZ domain//TFIIE beta subunit core domain//BTB/POZ domain GO:0051260//GO:0006367//GO:0019089 protein homooligomerization//transcription initiation from RNA polymerase II promoter//transmission of virus GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- KOG2716 Polymerase delta-interacting protein PDIP1 and related proteins, contain BTB/POZ domain Cluster-8309.31310 BF_2 29.14 0.46 2917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.31312 BF_2 98.64 1.23 3645 642922869 XP_008200431.1 2031 7.4e-225 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1465 1.3e-160 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF00664//PF01926//PF13304//PF12844//PF00236 ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Helix-turn-helix domain//Glycoprotein hormone GO:0007165//GO:0055085//GO:0006810 signal transduction//transmembrane transport//transport GO:0005525//GO:0043565//GO:0016887//GO:0042626//GO:0005524//GO:0005179//GO:0003924 GTP binding//sequence-specific DNA binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//hormone activity//GTPase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.31313 BF_2 53.98 0.62 3912 642922869 XP_008200431.1 2781 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] 768439826 XM_011563263.1 40 1.03177e-08 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1410 3.3e-154 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF00664//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//ABC transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.31314 BF_2 14.00 0.93 919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31315 BF_2 74.91 3.19 1268 642920261 XP_008192272.1 619 1.4e-61 PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920263|ref|XP_008192273.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920265|ref|XP_008192274.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|642920267|ref|XP_008192275.1| PREDICTED: anoctamin-1-like isoform X1 [Tribolium castaneum]>gi|270005277|gb|EFA01725.1| hypothetical protein TcasGA2_TC007305 [Tribolium castaneum] -- -- -- -- -- K19480 ANO5, GDD1, TMEM16E anoctamin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K19480 Q75V66 183 2.0e-12 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF01091//PF16178 PTN/MK heparin-binding protein family, C-terminal domain//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0008283//GO:0007165//GO:0040007//GO:0006811 cell proliferation//signal transduction//growth//ion transport GO:0046983//GO:0008083//GO:0005216 protein dimerization activity//growth factor activity//ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.31317 BF_2 112.56 4.21 1406 270009583 EFA06031.1 842 2.1e-87 hypothetical protein TcasGA2_TC008861 [Tribolium castaneum] -- -- -- -- -- K09646 SCPEP1 serine carboxypeptidase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09646 Q920A6 646 4.6e-66 Retinoid-inducible serine carboxypeptidase OS=Rattus norvegicus GN=Scpep1 PE=2 SV=1 PF00450 Serine carboxypeptidase GO:0006508 proteolysis GO:0004185 serine-type carboxypeptidase activity -- -- KOG1283 Serine carboxypeptidases Cluster-8309.31318 BF_2 188.32 1.48 5626 478257589 ENN77743.1 1238 1.0e-132 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 792 2.2e-82 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF02254//PF00389//PF00899//PF03446//PF02826//PF08783//PF15453//PF03435//PF02325//PF13241//PF01408 TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//DWNN domain//Protein incorporated later into Tight Junctions//Saccharopine dehydrogenase NADP binding domain//YGGT family//Putative NAD(P)-binding//Oxidoreductase family, NAD-binding Rossmann fold GO:0055114//GO:0006779//GO:0019521//GO:0006813//GO:0006098//GO:0008152//GO:0019354 oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process//potassium ion transport//pentose-phosphate shunt//metabolic process//siroheme biosynthetic process GO:0016616//GO:0004616//GO:0008270//GO:0051287//GO:0016491//GO:0043115//GO:0008641 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//zinc ion binding//NAD binding//oxidoreductase activity//precorrin-2 dehydrogenase activity//small protein activating enzyme activity GO:0005923//GO:0005634//GO:0016020 bicellular tight junction//nucleus//membrane -- -- Cluster-8309.31320 BF_2 5.00 0.42 784 641672832 XP_008186080.1 171 7.5e-10 PREDICTED: longitudinals lacking protein, isoforms N/O/W/X/Y-like isoform X2 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q867Z4 141 9.3e-08 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF01155//PF06524//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//NOA36 protein//BED zinc finger GO:0006464 cellular protein modification process GO:0046872//GO:0016151//GO:0003677//GO:0008270 metal ion binding//nickel cation binding//DNA binding//zinc ion binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.31321 BF_2 67.52 1.07 2916 668458814 KFB46677.1 1068 2.7e-113 hypothetical protein ZHAS_00014689 [Anopheles sinensis] -- -- -- -- -- K13577 SLC25A10, DIC solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13577 Q9UBX3 826 1.3e-86 Mitochondrial dicarboxylate carrier OS=Homo sapiens GN=SLC25A10 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.31322 BF_2 186.40 4.50 2021 642934979 XP_008199895.1 798 3.8e-82 PREDICTED: disintegrin and metalloproteinase domain-containing protein 12 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31323 BF_2 120.32 2.63 2201 270012994 EFA09442.1 809 2.2e-83 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] 690066085 LM584766.1 40 5.76756e-09 Haemonchus placei genome assembly H_placei_MHpl1 ,scaffold HPLM_scaffold0001704 K06834 ADAM9 disintegrin and metalloproteinase domain-containing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06834 Q61072 287 3.1e-24 Disintegrin and metalloproteinase domain-containing protein 9 OS=Mus musculus GN=Adam9 PE=1 SV=2 PF06701 Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0046872 ubiquitin-protein transferase activity//metal ion binding -- -- KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family Cluster-8309.31324 BF_2 43.00 156.08 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31325 BF_2 28.00 2.72 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31327 BF_2 2346.18 39.34 2782 189239791 XP_001811527.1 2811 0.0e+00 PREDICTED: oxysterol-binding protein 1 isoform X2 [Tribolium castaneum] 642930859 XM_001811475.2 237 2.2501e-118 PREDICTED: Tribolium castaneum oxysterol-binding protein 1 (LOC657071), transcript variant X2, mRNA -- -- -- -- P22059 1739 1.7e-192 Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1 SV=1 PF05854//PF02371 Non-histone chromosomal protein MC1//Transposase IS116/IS110/IS902 family GO:0042262//GO:0006313 DNA protection//transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.31328 BF_2 34.23 0.52 3030 270003538 EEZ99985.1 2520 1.2e-281 hypothetical protein TcasGA2_TC002784 [Tribolium castaneum] 124087411 XM_001346809.1 35 4.7966e-06 Paramecium tetraurelia strain d4-2 >gnl|BL_ORD_ID|3811472 Paramecium tetraurelia hypothetical protein (GSPATT00000539001) partial mRNA K14571 RIX7, NVL ribosome biogenesis ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14571 O15381 1068 1.2e-114 Nuclear valosin-containing protein-like OS=Homo sapiens GN=NVL PE=1 SV=1 PF00910//PF10662//PF00005//PF07726//PF01118//PF01637//PF00437//PF07724//PF14532//PF05496//PF01443//PF06068//PF00931//PF02562//PF06414//PF02367//PF00004//PF01695//PF07728//PF01057//PF00158 RNA helicase//Ethanolamine utilisation - propanediol utilisation//ABC transporter//ATPase family associated with various cellular activities (AAA)//Semialdehyde dehydrogenase, NAD binding domain//Archaeal ATPase//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//TIP49 C-terminus//NB-ARC domain//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain GO:0006281//GO:0006810//GO:0019079//GO:0055114//GO:0006355//GO:0006576//GO:0006310//GO:0002949 DNA repair//transport//viral genome replication//oxidation-reduction process//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0005524//GO:0016620//GO:0016887//GO:0016301//GO:0043531//GO:0051287//GO:0003723//GO:0003678//GO:0003724//GO:0009378 transcription factor binding//ATP binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//ATPase activity//kinase activity//ADP binding//NAD binding//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005667//GO:0005657 Holliday junction helicase complex//transcription factor complex//replication fork KOG0733 Nuclear AAA ATPase (VCP subfamily) Cluster-8309.31329 BF_2 2.00 1.40 341 270004866 EFA01314.1 291 4.0e-24 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K06252 TN tenascin http://www.genome.jp/dbget-bin/www_bget?ko:K06252 A2AV25 217 6.2e-17 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31330 BF_2 495.00 19.91 1327 189235591 XP_968043.2 925 4.7e-97 PREDICTED: uncharacterized protein LOC656417 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31332 BF_2 3133.70 20.83 6581 478260541 ENN80244.1 792 6.2e-81 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 1.30864e-29 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q93096 517 2.0e-50 Protein tyrosine phosphatase type IVA 1 OS=Homo sapiens GN=PTP4A1 PE=1 SV=2 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.31333 BF_2 874.50 27.34 1625 270008621 EFA05069.1 151 3.3e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.31334 BF_2 201.17 1.56 5692 642919375 XP_008191845.1 1782 8.6e-196 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P35969 566 3.6e-56 Vascular endothelial growth factor receptor 1 OS=Mus musculus GN=Flt1 PE=1 SV=1 PF07714//PF06293//PF00069//PF01325//PF13895//PF02480 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0006468 protein phosphorylation GO:0003677//GO:0005524//GO:0016773//GO:0004672//GO:0005515 DNA binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.31335 BF_2 136.06 1.43 4264 642919375 XP_008191845.1 3290 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 5.0e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF02480//PF13895//PF01325//PF00069//PF07714 Alphaherpesvirus glycoprotein E//Immunoglobulin domain//Iron dependent repressor, N-terminal DNA binding domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0003677//GO:0005524//GO:0005515//GO:0004672 DNA binding//ATP binding//protein binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.31336 BF_2 18.27 1.22 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31337 BF_2 116.00 11.73 701 642940094 XP_008192960.1 524 7.9e-51 PREDICTED: paxillin isoform X5 [Tribolium castaneum] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8VI36 430 2.6e-41 Paxillin OS=Mus musculus GN=Pxn PE=1 SV=1 PF00412//PF00097 LIM domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.31338 BF_2 951.93 8.23 5128 546676645 ERL87609.1 2223 5.6e-247 hypothetical protein D910_05000, partial [Dendroctonus ponderosae] -- -- -- -- -- K04659 THBS2S thrombospondin 2/3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04659 P49747 1725 1.3e-190 Cartilage oligomeric matrix protein OS=Homo sapiens GN=COMP PE=1 SV=2 PF07645//PF00008//PF02412//PF05735 Calcium-binding EGF domain//EGF-like domain//Thrombospondin type 3 repeat//Thrombospondin C-terminal region GO:0007155 cell adhesion GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.31340 BF_2 599.92 11.84 2406 573896974 XP_006636225.1 151 4.8e-07 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- C0HJF3 141 2.9e-07 Analgesic polypeptide HC3 OS=Heteractis crispa PE=1 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.31342 BF_2 155.45 2.30 3112 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31344 BF_2 2551.57 22.67 4995 749735952 XP_011154160.1 3469 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X1 [Harpegnathos saltator]>gi|307212553|gb|EFN88276.1| Armadillo segment polarity protein [Harpegnathos saltator] 642934620 XM_008199519.1 694 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 3286 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF07646//PF02985//PF10508//PF01344//PF00514//PF01602 Kelch motif//HEAT repeat//Proteasome non-ATPase 26S subunit//Kelch motif//Armadillo/beta-catenin-like repeat//Adaptin N terminal region GO:0043248//GO:0016192//GO:0006886 proteasome assembly//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.31346 BF_2 48.00 2.68 1036 699253217 XP_009861051.1 140 3.9e-06 PREDICTED: ovochymase-1-like [Ciona intestinalis] -- -- -- -- -- -- -- -- -- Q90WD8 138 2.7e-07 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.31347 BF_2 422.14 33.08 821 642931082 XP_008196202.1 474 5.8e-45 PREDICTED: aquaporin-12 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31348 BF_2 282.95 29.02 695 270012071 EFA08519.1 525 6.0e-51 hypothetical protein TcasGA2_TC006172 [Tribolium castaneum] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.31349 BF_2 258.81 5.11 2404 332373408 AEE61845.1 1537 9.3e-168 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 563 3.3e-56 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31350 BF_2 40.05 1.08 1834 270012071 EFA08519.1 269 7.7e-21 hypothetical protein TcasGA2_TC006172 [Tribolium castaneum] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF01914//PF01967 MarC family integral membrane protein//MoaC family GO:0006777 Mo-molybdopterin cofactor biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31354 BF_2 214.98 8.50 1345 478251082 ENN71558.1 897 8.5e-94 hypothetical protein YQE_11660, partial [Dendroctonus ponderosae]>gi|546671909|gb|ERL84016.1| hypothetical protein D910_01335 [Dendroctonus ponderosae]>gi|546671968|gb|ERL84050.1| hypothetical protein D910_01379 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P04572 289 1.1e-24 Sarcoplasmic calcium-binding protein OS=Perinereis vancaurica tetradentata PE=1 SV=1 PF13499//PF05983//PF10591//PF13833//PF00036//PF13405//PF13202 EF-hand domain pair//MED7 protein//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF hand GO:0007165//GO:0006357 signal transduction//regulation of transcription from RNA polymerase II promoter GO:0005509//GO:0001104 calcium ion binding//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005578 mediator complex//proteinaceous extracellular matrix -- -- Cluster-8309.31357 BF_2 452.94 34.15 842 642919270 XP_008191803.1 234 4.0e-17 PREDICTED: copper transport protein ATOX1 [Tribolium castaneum] -- -- -- -- -- K07213 ATOX1, ATX1, copZ, golB copper chaperone http://www.genome.jp/dbget-bin/www_bget?ko:K07213 Q94BT9 163 2.8e-10 Copper transport protein ATX1 OS=Arabidopsis thaliana GN=ATX1 PE=1 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG1603 Copper chaperone Cluster-8309.31359 BF_2 114.24 1.37 3770 642911061 XP_008200558.1 3118 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 524 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2476 7.8e-278 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF02535//PF00520//PF05887 ZIP Zinc transporter//Ion transport protein//Procyclic acidic repetitive protein (PARP) GO:0030001//GO:0055085//GO:0006811 metal ion transport//transmembrane transport//ion transport GO:0005216//GO:0046873 ion channel activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.31362 BF_2 105.00 6.74 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31363 BF_2 72.85 3.11 1267 642913478 XP_008201029.1 407 5.2e-37 PREDICTED: dolichol kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31365 BF_2 70.00 1.39 2387 641661214 XP_008181794.1 635 3.6e-63 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q03923 613 5.3e-62 Zinc finger protein 85 OS=Homo sapiens GN=ZNF85 PE=1 SV=3 PF13465//PF00096//PF13912//PF00999//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Sodium/hydrogen exchanger family//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0055085//GO:0006885//GO:0006812 transmembrane transport//regulation of pH//cation transport GO:0015299//GO:0008270//GO:0046872 solute:proton antiporter activity//zinc ion binding//metal ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.31369 BF_2 236.83 3.33 3266 642935994 XP_008198261.1 2201 1.3e-244 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X4 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1685 3.6e-186 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.31371 BF_2 63.87 0.81 3606 642928339 XP_008195541.1 1614 1.6e-176 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog-like isoform X1 [Tribolium castaneum] 571531697 XM_006570187.1 76 9.23795e-29 PREDICTED: Apis mellifera synaptic vesicle membrane protein VAT-1 homolog-like (LOC409207), mRNA -- -- -- -- Q9HCJ6 992 9.0e-106 Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens GN=VAT1L PE=1 SV=2 PF10152//PF08240//PF00951//PF02862//PF01118//PF02724//PF06459//PF00107 Predicted coiled-coil domain-containing protein (DUF2360)//Alcohol dehydrogenase GroES-like domain//Arterivirus GL envelope glycoprotein//DDHD domain//Semialdehyde dehydrogenase, NAD binding domain//CDC45-like protein//Ryanodine Receptor TM 4-6//Zinc-binding dehydrogenase GO:0055114//GO:0006874//GO:0006270//GO:0006816 oxidation-reduction process//cellular calcium ion homeostasis//DNA replication initiation//calcium ion transport GO:0046872//GO:0016620//GO:0051287//GO:0005219 metal ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding//ryanodine-sensitive calcium-release channel activity GO:0071203//GO:0005622//GO:0019031//GO:0016021 WASH complex//intracellular//viral envelope//integral component of membrane KOG1197 Predicted quinone oxidoreductase Cluster-8309.31373 BF_2 451.79 5.16 3953 642918588 XP_008197437.1 1427 8.7e-155 PREDICTED: RNA-binding Raly-like protein [Tribolium castaneum] 642918587 XM_008199215.1 344 1.06043e-177 PREDICTED: Tribolium castaneum RNA-binding Raly-like protein (LOC103314137), mRNA -- -- -- -- P19600 314 4.1e-27 Heterogeneous nuclear ribonucleoprotein C OS=Xenopus laevis GN=hnrnpc PE=2 SV=1 PF00096//PF00076 Zinc finger, C2H2 type//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0046872 nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.31374 BF_2 480.16 12.66 1874 478255055 ENN75285.1 838 8.2e-87 hypothetical protein YQE_08062, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31377 BF_2 526.19 1.96 11524 642928433 XP_008193783.1 6548 0.0e+00 PREDICTED: proteasome activator complex subunit 4 [Tribolium castaneum]>gi|270010813|gb|EFA07261.1| hypothetical protein TcasGA2_TC013292 [Tribolium castaneum] -- -- -- -- -- K06699 PSME4 proteasome activator subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06699 Q14997 3168 0.0e+00 Proteasome activator complex subunit 4 OS=Homo sapiens GN=PSME4 PE=1 SV=2 PF01000//PF06743//PF00590//PF01193//PF02985 RNA polymerase Rpb3/RpoA insert domain//FAST kinase-like protein, subdomain 1//Tetrapyrrole (Corrin/Porphyrin) Methylases//RNA polymerase Rpb3/Rpb11 dimerisation domain//HEAT repeat GO:0006206//GO:0006144//GO:0008152//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//metabolic process//transcription, DNA-templated GO:0004672//GO:0008168//GO:0046983//GO:0005515//GO:0003899 protein kinase activity//methyltransferase activity//protein dimerization activity//protein binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG1521 RNA polymerase I and III, subunit RPA40/RPC40 Cluster-8309.31378 BF_2 77.56 0.88 3962 546673279 ERL84915.1 371 2.5e-32 hypothetical protein D910_02338 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.31381 BF_2 58.56 0.32 7904 642913878 XP_975183.2 7115 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X1 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.54017e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q96C24 760 1.6e-78 Synaptotagmin-like protein 4 OS=Homo sapiens GN=SYTL4 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.31382 BF_2 537.64 2.37 9766 642929667 XP_008195928.1 6968 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X1 [Tribolium castaneum] 642929668 XM_970393.2 238 2.21583e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 2114 1.9e-235 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF02145//PF03367//PF04135//PF03110//PF00130//PF01155 Rap/ran-GAP//ZPR1 zinc-finger domain//Nucleolar RNA-binding protein, Nop10p family//SBP domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0042254//GO:0035556//GO:0001522//GO:0051056 cellular protein modification process//ribosome biogenesis//intracellular signal transduction//pseudouridine synthesis//regulation of small GTPase mediated signal transduction GO:0016151//GO:0030515//GO:0005096//GO:0003677//GO:0008270 nickel cation binding//snoRNA binding//GTPase activator activity//DNA binding//zinc ion binding GO:0005634//GO:0072588 nucleus//box H/ACA RNP complex KOG2703 C4-type Zn-finger protein Cluster-8309.31383 BF_2 572.69 1.44 16960 270012570 EFA09018.1 2931 0.0e+00 hypothetical protein TcasGA2_TC006727 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07929 194 1.4e-12 63 kDa sperm flagellar membrane protein OS=Strongylocentrotus purpuratus PE=2 SV=1 PF00008//PF00335//PF07645 EGF-like domain//Tetraspanin family//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021 integral component of membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.31386 BF_2 138.00 5.63 1313 189235452 XP_971512.2 1546 4.6e-169 PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum]>gi|642916717|ref|XP_008192324.1| PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum] 831223446 XM_012804270.1 56 4.34024e-18 PREDICTED: Otolemur garnettii coiled-coil domain containing 102B (CCDC102B), mRNA K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q6NZW0 743 2.4e-77 Coiled-coil domain-containing protein 102A OS=Danio rerio GN=ccdc102a PE=2 SV=1 PF04513//PF00038//PF04111 Baculovirus polyhedron envelope protein, PEP, C terminus//Intermediate filament protein//Autophagy protein Apg6 GO:0006914 autophagy GO:0005198 structural molecule activity GO:0019028//GO:0005882//GO:0019031 viral capsid//intermediate filament//viral envelope -- -- Cluster-8309.31387 BF_2 299.72 1.16 11099 642918318 XP_008191457.1 7327 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 195492470 XM_002093969.1 257 6.90652e-129 Drosophila yakuba GE20438 (Dyak\GE20438), partial mRNA -- -- -- -- Q9VS29 6236 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF04120//PF00041//PF16656//PF07749 Immunoglobulin domain//Low affinity iron permease//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0019497//GO:0055085//GO:0006771 hexachlorocyclohexane metabolic process//transmembrane transport//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.31388 BF_2 1156.74 6.55 7677 91082255 XP_973064.1 2364 3.8e-263 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62046 915 1.6e-96 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus GN=Lrch1 PE=1 SV=2 PF00307//PF13855//PF00560 Calponin homology (CH) domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.31392 BF_2 101.04 5.41 1069 642913226 XP_975254.2 496 2.1e-47 PREDICTED: protein CutA homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K03926 cutA periplasmic divalent cation tolerance protein http://www.genome.jp/dbget-bin/www_bget?ko:K03926 Q66KY3 390 1.7e-36 Protein CutA homolog OS=Xenopus laevis GN=cuta PE=2 SV=2 PF03091 CutA1 divalent ion tolerance protein GO:0010038 response to metal ion -- -- -- -- KOG3338 Divalent cation tolerance-related protein Cluster-8309.31393 BF_2 467.48 2.78 7327 91085649 XP_970922.1 6731 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R422 759 1.9e-78 CD109 antigen OS=Mus musculus GN=Cd109 PE=2 SV=1 PF00057//PF00432//PF00207//PF07678//PF01835//PF06617//PF07677 Low-density lipoprotein receptor domain class A//Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//A-macroglobulin complement component//MG2 domain//M-phase inducer phosphatase//A-macroglobulin receptor GO:0010951//GO:0006570//GO:0000087//GO:0006470 negative regulation of endopeptidase activity//tyrosine metabolic process//mitotic M phase//protein dephosphorylation GO:0003824//GO:0004866//GO:0005515//GO:0004725 catalytic activity//endopeptidase inhibitor activity//protein binding//protein tyrosine phosphatase activity GO:0005576//GO:0005622//GO:0005615 extracellular region//intracellular//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.31395 BF_2 54.00 1.76 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31397 BF_2 84.00 2.13 1936 91081383 XP_972269.1 910 3.8e-95 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 1 [Tribolium castaneum]>gi|642920804|ref|XP_008192568.1| PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 1 [Tribolium castaneum]>gi|642920806|ref|XP_008192569.1| PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 1 [Tribolium castaneum]>gi|270006117|gb|EFA02565.1| hypothetical protein TcasGA2_TC008275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 264 1.3e-21 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.31398 BF_2 283.00 26.85 728 91080781 XP_968744.1 585 6.9e-58 PREDICTED: 40S ribosomal protein S12, mitochondrial [Tribolium castaneum]>gi|270005434|gb|EFA01882.1| hypothetical protein TcasGA2_TC007491 [Tribolium castaneum] -- -- -- -- -- K02950 RP-S12, MRPS12, rpsL small subunit ribosomal protein S12 http://www.genome.jp/dbget-bin/www_bget?ko:K02950 P10735 447 2.9e-43 40S ribosomal protein S12, mitochondrial OS=Drosophila melanogaster GN=tko PE=1 SV=1 PF00164 Ribosomal protein S12/S23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0015935//GO:0005840 intracellular//small ribosomal subunit//ribosome KOG1750 Mitochondrial/chloroplast ribosomal protein S12 Cluster-8309.31399 BF_2 187.76 3.00 2904 189238197 XP_001807880.1 2962 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|642925484|ref|XP_008194570.1| PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|270008848|gb|EFA05296.1| hypothetical protein TcasGA2_TC015453 [Tribolium castaneum] 755988497 XM_011313566.1 279 1.05538e-141 PREDICTED: Fopius arisanus eukaryotic translation initiation factor 3 subunit C (LOC105271805), mRNA K03252 EIF3C translation initiation factor 3 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K03252 Q17Q06 2380 8.2e-267 Eukaryotic translation initiation factor 3 subunit C OS=Aedes aegypti GN=eIF3-S8 PE=3 SV=1 PF05470//PF01399 Eukaryotic translation initiation factor 3 subunit 8 N-terminus//PCI domain GO:0006446//GO:0006412//GO:0006413 regulation of translational initiation//translation//translational initiation GO:0003743//GO:0005515//GO:0031369 translation initiation factor activity//protein binding//translation initiation factor binding GO:0005840//GO:0005852//GO:0005737 ribosome//eukaryotic translation initiation factor 3 complex//cytoplasm KOG1076 Translation initiation factor 3, subunit c (eIF-3c) Cluster-8309.31401 BF_2 45.46 0.49 4138 282165788 NP_001164133.1 939 3.5e-98 scavenger receptor protein [Tribolium castaneum]>gi|270009221|gb|EFA05669.1| hypothetical protein TcasGA2_TC014951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61009 458 8.6e-44 Scavenger receptor class B member 1 OS=Mus musculus GN=Scarb1 PE=1 SV=1 PF01130//PF04790 CD36 family//Sarcoglycan complex subunit protein GO:0007155 cell adhesion -- -- GO:0016012//GO:0016021//GO:0016020 sarcoglycan complex//integral component of membrane//membrane -- -- Cluster-8309.31403 BF_2 366.00 45.58 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- O81338 132 8.2e-07 Antimicrobial peptide 1 OS=Mesembryanthemum crystallinum PE=3 SV=1 PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31407 BF_2 10.63 0.92 770 642923248 XP_008193675.1 225 4.1e-16 PREDICTED: aquaporin AQPcic [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.31408 BF_2 121.75 1.18 4608 546684929 ERL94511.1 246 8.9e-18 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF01363 Zinc-finger associated domain (zf-AD)//FYVE zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.31410 BF_2 285.31 27.70 718 91083623 XP_970124.1 965 5.9e-102 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] 755984491 XM_011312239.1 134 1.01441e-61 PREDICTED: Fopius arisanus probable citrate synthase 2, mitochondrial (LOC105270973), transcript variant X2, mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q16P20 896 2.4e-95 Probable citrate synthase 2, mitochondrial OS=Aedes aegypti GN=AAEL011789 PE=3 SV=1 PF00285 Citrate synthase GO:0046487//GO:0006099//GO:0044262 glyoxylate metabolic process//tricarboxylic acid cycle//cellular carbohydrate metabolic process GO:0004108//GO:0046912 citrate (Si)-synthase activity//transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer -- -- KOG2617 Citrate synthase Cluster-8309.31411 BF_2 5514.60 80.78 3143 91083623 XP_970124.1 1221 5.3e-131 PREDICTED: probable citrate synthase 2, mitochondrial [Tribolium castaneum]>gi|270006831|gb|EFA03279.1| hypothetical protein TcasGA2_TC013214 [Tribolium castaneum] 332373859 BT127109.1 235 3.29333e-117 Dendroctonus ponderosae clone DPO016_K18 unknown mRNA K01647 CS, gltA citrate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01647 Q17GM7 1151 2.9e-124 Probable citrate synthase 1, mitochondrial OS=Aedes aegypti GN=AAEL002956 PE=3 SV=1 PF00285//PF02892//PF16622//PF01429//PF00320//PF00096//PF13465 Citrate synthase//BED zinc finger//zinc-finger C2H2-type//Methyl-CpG binding domain//GATA zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006099//GO:0006355//GO:0044262//GO:0046487 tricarboxylic acid cycle//regulation of transcription, DNA-templated//cellular carbohydrate metabolic process//glyoxylate metabolic process GO:0008270//GO:0043565//GO:0004108//GO:0003700//GO:0046872//GO:0046912//GO:0003677 zinc ion binding//sequence-specific DNA binding//citrate (Si)-synthase activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG2617 Citrate synthase Cluster-8309.31412 BF_2 66.00 1.38 2290 642937652 XP_966876.3 580 8.3e-57 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17010 364 3.8e-33 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF07776//PF02751//PF05401//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Transcription initiation factor IIA, gamma subunit//Nodulation protein S (NodS)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0009877//GO:0006367//GO:0009312 nodulation//transcription initiation from RNA polymerase II promoter//oligosaccharide biosynthetic process GO:0008270//GO:0046872//GO:0008757 zinc ion binding//metal ion binding//S-adenosylmethionine-dependent methyltransferase activity GO:0005672//GO:0005634 transcription factor TFIIA complex//nucleus -- -- Cluster-8309.31414 BF_2 85.00 12.52 571 642920639 XP_008192499.1 329 2.6e-28 PREDICTED: uncharacterized protein LOC103312788 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31417 BF_2 14.00 0.86 970 780089478 XP_011673857.1 343 1.1e-29 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 249 3.5e-20 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31418 BF_2 2.00 23.67 229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31419 BF_2 36.00 3.80 683 780089478 XP_011673857.1 246 1.3e-18 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q8N8A2 204 4.0e-15 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31420 BF_2 10.00 1.59 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31421 BF_2 2663.19 48.00 2608 91078216 XP_969175.1 1172 2.1e-125 PREDICTED: surfeit locus protein 4 homolog [Tribolium castaneum]>gi|270001352|gb|EEZ97799.1| hypothetical protein TcasGA2_TC000161 [Tribolium castaneum] 225718617 BT080731.1 73 3.09866e-27 Caligus clemensi clone ccle-evs-519-002 Surfeit locus protein 4 homolog putative mRNA, complete cds K03593 mrp, NUBPL ATP-binding protein involved in chromosome partitioning http://www.genome.jp/dbget-bin/www_bget?ko:K03593 O18405 988 1.9e-105 Surfeit locus protein 4 homolog OS=Drosophila melanogaster GN=Surf4 PE=2 SV=1 PF02077//PF03419 SURF4 family//Sporulation factor SpoIIGA GO:0030436//GO:0006508 asexual sporulation//proteolysis GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.31423 BF_2 370.00 255.74 342 501298484 BAN21346.1 219 8.9e-16 unkown protein [Riptortus pedestris] -- -- -- -- -- K00419 QCR9, UCRC ubiquinol-cytochrome c reductase subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K00419 P00130 178 2.1e-12 Cytochrome b-c1 complex subunit 9 OS=Bos taurus GN=UQCR10 PE=1 SV=3 PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005743//GO:0005750 mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-8309.31424 BF_2 223.91 3.89 2697 91089013 XP_968301.1 2664 2.2e-298 PREDICTED: RINT1-like protein [Tribolium castaneum]>gi|270011539|gb|EFA07987.1| hypothetical protein TcasGA2_TC005574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NUQ1 1052 7.4e-113 RAD50-interacting protein 1 OS=Homo sapiens GN=RINT1 PE=1 SV=1 PF08702//PF04437//PF05384//PF06008 Fibrinogen alpha/beta chain family//RINT-1 / TIP-1 family//Sensor protein DegS//Laminin Domain I GO:0051258//GO:0048193//GO:0007165//GO:0030334//GO:0045995//GO:0030155//GO:0030168 protein polymerization//Golgi vesicle transport//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of cell adhesion//platelet activation GO:0030674//GO:0005102//GO:0016301 protein binding, bridging//receptor binding//kinase activity GO:0005783//GO:0005577 endoplasmic reticulum//fibrinogen complex -- -- Cluster-8309.31425 BF_2 80.28 7.09 761 91080601 XP_974038.1 569 5.2e-56 PREDICTED: mediator of RNA polymerase II transcription subunit 7 [Tribolium castaneum]>gi|270005511|gb|EFA01959.1| hypothetical protein TcasGA2_TC007575 [Tribolium castaneum] -- -- -- -- -- K15148 MED7 mediator of RNA polymerase II transcription subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15148 Q7PR68 365 9.6e-34 Mediator of RNA polymerase II transcription subunit 7 OS=Anopheles gambiae GN=MED7 PE=3 SV=2 PF00042 Globin GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0020037//GO:0001104//GO:0019825 heme binding//RNA polymerase II transcription cofactor activity//oxygen binding GO:0016592 mediator complex KOG0570 Transcriptional coactivator Cluster-8309.31426 BF_2 205.36 1.35 6663 817053828 XP_012264100.1 1826 7.9e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935876 XR_511652.1 647 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X4, misc_RNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 Q9UBE8 1597 1.2e-175 Serine/threonine-protein kinase NLK OS=Homo sapiens GN=NLK PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.31428 BF_2 40.25 1.33 1552 642928886 XP_008195603.1 400 4.2e-36 PREDICTED: junctional adhesion molecule B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31430 BF_2 19.37 0.40 2326 91083613 XP_969708.1 722 2.9e-73 PREDICTED: calmodulin [Tribolium castaneum]>gi|270007842|gb|EFA04290.1| hypothetical protein TcasGA2_TC014581 [Tribolium castaneum] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 407 4.0e-38 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.31432 BF_2 84.41 1.87 2173 91083611 XP_969629.1 878 2.2e-91 PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|642924148|ref|XP_008194028.1| PREDICTED: mitochondrial coenzyme A transporter SLC25A42 [Tribolium castaneum]>gi|270006834|gb|EFA03282.1| hypothetical protein TcasGA2_TC013217 [Tribolium castaneum] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 558 1.1e-55 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 -- -- GO:0006810 transport -- -- GO:0016020 membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.31435 BF_2 124.00 2.57 2305 91091370 XP_972940.1 1297 6.0e-140 PREDICTED: radical S-adenosyl methionine domain-containing protein 2 [Tribolium castaneum]>gi|270013064|gb|EFA09512.1| hypothetical protein TcasGA2_TC011614 [Tribolium castaneum] -- -- -- -- -- K15045 RSAD2 radical S-adenosyl methionine domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15045 Q2HJF9 1128 9.8e-122 Radical S-adenosyl methionine domain-containing protein 2 OS=Bos taurus GN=RSAD2 PE=2 SV=1 PF04055 Radical SAM superfamily GO:0008152//GO:0051607 metabolic process//defense response to virus GO:0051536//GO:0003824 iron-sulfur cluster binding//catalytic activity GO:0005789//GO:0005811 endoplasmic reticulum membrane//lipid particle -- -- Cluster-8309.31436 BF_2 1814.00 136.28 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31438 BF_2 584.09 3.71 6877 349584988 BAL03254.1 1867 1.4e-205 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8TMP0 426 7.4e-40 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31439 BF_2 20.53 0.81 1351 270002027 EEZ98474.1 452 3.4e-42 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWD0 135 8.0e-07 Gametocyte-specific factor 1-like OS=Mus musculus GN=Gtsf1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4376 Uncharacterized conserved protein Cluster-8309.31440 BF_2 1060.16 5.79 7948 642911937 XP_008199029.1 3496 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 610 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1868 5.3e-207 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF03114//PF14604//PF00023//PF00018//PF08397//PF07043//PF00885//PF13606//PF00465//PF01412 BAR domain//Variant SH3 domain//Ankyrin repeat//SH3 domain//IRSp53/MIM homology domain//Protein of unknown function (DUF1328)//6,7-dimethyl-8-ribityllumazine synthase//Ankyrin repeat//Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf GO:0009231//GO:0007009//GO:0055114 riboflavin biosynthetic process//plasma membrane organization//oxidation-reduction process GO:0005096//GO:0005515//GO:0016491//GO:0046872 GTPase activator activity//protein binding//oxidoreductase activity//metal ion binding GO:0005886//GO:0009349//GO:0005737 plasma membrane//riboflavin synthase complex//cytoplasm KOG3857 Alcohol dehydrogenase, class IV Cluster-8309.31442 BF_2 534.45 3.07 7568 642917303 XP_008199243.1 7219 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X4 [Tribolium castaneum] 642917302 XM_008201021.1 1251 0 PREDICTED: Tribolium castaneum disco-interacting protein 2 (LOC657292), transcript variant X4, mRNA -- -- -- -- Q9W0S9 5111 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF17096//PF06464//PF00501 Altered inheritance of mitochondria protein 3//DMAP1-binding Domain//AMP-binding enzyme GO:0051016//GO:0008152 barbed-end actin filament capping//metabolic process GO:0003824//GO:0008134 catalytic activity//transcription factor binding GO:0030479//GO:0005634//GO:0005667 actin cortical patch//nucleus//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.31443 BF_2 1316.00 42.71 1576 189239379 XP_971918.2 694 3.4e-70 PREDICTED: receptor expression-enhancing protein 5 [Tribolium castaneum]>gi|270009667|gb|EFA06115.1| hypothetical protein TcasGA2_TC008958 [Tribolium castaneum] -- -- -- -- -- K17279 REEP5_6 receptor expression-enhancing protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K17279 Q5RE33 493 2.9e-48 Receptor expression-enhancing protein 5 OS=Pongo abelii GN=REEP5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.31446 BF_2 164.59 0.79 8953 642917303 XP_008199243.1 7005 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X4 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3668 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF02710//PF02784//PF00501 DMAP1-binding Domain//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//Pyridoxal-dependent decarboxylase, pyridoxal binding domain//AMP-binding enzyme GO:0007165//GO:0008152//GO:0019064 signal transduction//metabolic process//fusion of virus membrane with host plasma membrane GO:0046789//GO:0003824//GO:0016788//GO:0008134 host cell surface receptor binding//catalytic activity//hydrolase activity, acting on ester bonds//transcription factor binding GO:0009986//GO:0005634//GO:0005667//GO:0019031 cell surface//nucleus//transcription factor complex//viral envelope KOG3628 Predicted AMP-binding protein Cluster-8309.31448 BF_2 558.26 24.28 1249 91083635 XP_970519.1 1462 2.4e-159 PREDICTED: hydroxyacid oxidase 1 [Tribolium castaneum] -- -- -- -- -- K11517 HAO (S)-2-hydroxy-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K11517 Q9UJM8 1028 2.1e-110 Hydroxyacid oxidase 1 OS=Homo sapiens GN=HAO1 PE=1 SV=1 PF00977//PF00478//PF03060//PF04309//PF01070//PF01645//PF01180 Histidine biosynthesis protein//IMP dehydrogenase / GMP reductase domain//Nitronate monooxygenase//Glycerol-3-phosphate responsive antiterminator//FMN-dependent dehydrogenase//Conserved region in glutamate synthase//Dihydroorotate dehydrogenase GO:0009607//GO:0006355//GO:0000105//GO:0006807//GO:0055114//GO:0006537 response to biotic stimulus//regulation of transcription, DNA-templated//histidine biosynthetic process//nitrogen compound metabolic process//oxidation-reduction process//glutamate biosynthetic process GO:0016638//GO:0015930//GO:0016627//GO:0018580//GO:0003824//GO:0016491 oxidoreductase activity, acting on the CH-NH2 group of donors//glutamate synthase activity//oxidoreductase activity, acting on the CH-CH group of donors//nitronate monooxygenase activity//catalytic activity//oxidoreductase activity GO:0005737 cytoplasm KOG0538 Glycolate oxidase Cluster-8309.31449 BF_2 322.00 3.07 4677 189234745 XP_974217.2 4064 0.0e+00 PREDICTED: tetratricopeptide repeat protein 21B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z4L5 2203 4.4e-246 Tetratricopeptide repeat protein 21B OS=Homo sapiens GN=TTC21B PE=1 SV=2 PF13414//PF13174//PF13176//PF13371//PF00515//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31450 BF_2 645.74 18.92 1715 270004718 EFA01166.1 2156 1.1e-239 hypothetical protein TcasGA2_TC010489 [Tribolium castaneum] 156481745 EU093075.1 889 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 1.0e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF00394//PF07732//PF07731 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- KOG1263 Multicopper oxidases Cluster-8309.31451 BF_2 16.10 0.40 1969 91076790 XP_974060.1 878 2.0e-91 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9H8 465 6.3e-45 Apoptotic protease-activating factor 1 OS=Danio rerio GN=apaf1 PE=2 SV=1 PF00931//PF02020 NB-ARC domain//eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515//GO:0043531 protein binding//ADP binding -- -- -- -- Cluster-8309.31452 BF_2 86.05 2.75 1597 270012861 EFA09309.1 929 2.0e-97 hypothetical protein TcasGA2_TC030652 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q80UG8 659 1.6e-67 Tubulin polyglutamylase TTLL4 OS=Mus musculus GN=Ttll4 PE=2 SV=3 PF03171//PF03133 2OG-Fe(II) oxygenase superfamily//Tubulin-tyrosine ligase family GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31455 BF_2 10.71 0.31 1737 642933082 XP_008197252.1 1235 7.0e-133 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q80UG8 881 3.2e-93 Tubulin polyglutamylase TTLL4 OS=Mus musculus GN=Ttll4 PE=2 SV=3 PF03133//PF03171 Tubulin-tyrosine ligase family//2OG-Fe(II) oxygenase superfamily GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31456 BF_2 26.16 0.72 1813 642933086 XP_008197254.1 1513 4.3e-165 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1020 2.6e-109 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133//PF03171//PF02655 Tubulin-tyrosine ligase family//2OG-Fe(II) oxygenase superfamily//ATP-grasp domain GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0005524//GO:0016491//GO:0046872 ATP binding//oxidoreductase activity//metal ion binding -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31457 BF_2 20.24 0.40 2417 546673099 ERL84768.1 749 2.2e-76 hypothetical protein D910_02193 [Dendroctonus ponderosae] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 311 5.6e-27 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.31458 BF_2 188.27 7.68 1312 642933084 XP_008197253.1 1531 2.5e-167 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1005 1.0e-107 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03171//PF03133 2OG-Fe(II) oxygenase superfamily//Tubulin-tyrosine ligase family GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31459 BF_2 632.25 40.58 939 478250603 ENN71095.1 798 1.8e-82 hypothetical protein YQE_12028, partial [Dendroctonus ponderosae] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 311 2.2e-27 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.31460 BF_2 34.83 0.64 2562 546673099 ERL84768.1 749 2.3e-76 hypothetical protein D910_02193 [Dendroctonus ponderosae] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 311 5.9e-27 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.31462 BF_2 441.76 8.13 2561 285403695 NP_001164137.1 1348 8.2e-146 Wnt6 protein precursor [Tribolium castaneum] -- -- -- -- -- K00445 WNT6 wingless-type MMTV integration site family, member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00445 Q9Y6F9 924 4.9e-98 Protein Wnt-6 OS=Homo sapiens GN=WNT6 PE=1 SV=2 PF00110 wnt family GO:0007275//GO:0016055//GO:0007165 multicellular organismal development//Wnt signaling pathway//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.31463 BF_2 323.24 6.09 2507 285403695 NP_001164137.1 1348 8.0e-146 Wnt6 protein precursor [Tribolium castaneum] -- -- -- -- -- K00445 WNT6 wingless-type MMTV integration site family, member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K00445 Q9Y6F9 924 4.8e-98 Protein Wnt-6 OS=Homo sapiens GN=WNT6 PE=1 SV=2 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.31464 BF_2 72.00 6.28 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31465 BF_2 445.20 6.46 3172 642928263 XP_001812997.2 1813 1.2e-199 PREDICTED: cyclin-T [Tribolium castaneum] -- -- -- -- -- K15188 CCNT cyclin T http://www.genome.jp/dbget-bin/www_bget?ko:K15188 O96433 749 1.2e-77 Cyclin-T OS=Drosophila melanogaster GN=CycT PE=1 SV=2 PF00528//PF02317 Binding-protein-dependent transport system inner membrane component//NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain GO:0055114//GO:0006810 oxidation-reduction process//transport GO:0016491//GO:0050662 oxidoreductase activity//coenzyme binding GO:0016020 membrane KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.31468 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31473 BF_2 617.81 4.41 6147 642935193 XP_008199686.1 2675 2.6e-299 PREDICTED: ATP-dependent RNA helicase abstrakt [Tribolium castaneum] 665786806 XM_008556015.1 412 0 PREDICTED: Microplitis demolitor ATP-dependent RNA helicase abstrakt (LOC103575994), mRNA K13116 DDX41, ABS ATP-dependent RNA helicase DDX41 http://www.genome.jp/dbget-bin/www_bget?ko:K13116 Q9V3C0 2220 6.2e-248 ATP-dependent RNA helicase abstrakt OS=Drosophila melanogaster GN=abs PE=1 SV=1 PF04851//PF00098//PF06862//PF01805//PF00096//PF06220//PF00270 Type III restriction enzyme, res subunit//Zinc knuckle//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//Surp module//Zinc finger, C2H2 type//U1 zinc finger//DEAD/DEAH box helicase GO:0006396 RNA processing GO:0008270//GO:0003676//GO:0046872//GO:0005524//GO:0003723//GO:0003677//GO:0016787 zinc ion binding//nucleic acid binding//metal ion binding//ATP binding//RNA binding//DNA binding//hydrolase activity GO:0005634 nucleus KOG0341 DEAD-box protein abstrakt Cluster-8309.31474 BF_2 186.00 11.53 962 -- -- -- -- -- 826416851 XM_012667750.1 40 2.47183e-09 PREDICTED: Monomorium pharaonis tubulin beta chain (LOC105829097), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31475 BF_2 918.88 26.60 1732 91079210 XP_966588.1 982 1.5e-103 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial [Tribolium castaneum]>gi|270004834|gb|EFA01282.1| hypothetical protein TcasGA2_TC002817 [Tribolium castaneum] 699239055 XM_002131725.3 75 1.57987e-28 PREDICTED: Ciona intestinalis NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (LOC100183052), mRNA K03936 NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03936 P23709 791 8.8e-83 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial OS=Bos taurus GN=NDUFS3 PE=1 SV=1 PF00329 Respiratory-chain NADH dehydrogenase, 30 Kd subunit GO:0015992//GO:0055114//GO:0006814//GO:0006120//GO:0006744 proton transport//oxidation-reduction process//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG1713 NADH-ubiquinone oxidoreductase, NDUFS3/30 kDa subunit Cluster-8309.31476 BF_2 203.19 5.62 1799 546686189 ERL95569.1 1395 2.0e-151 hypothetical protein D910_12830 [Dendroctonus ponderosae] -- -- -- -- -- K09881 AGK acylglycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09881 Q53H12 619 8.0e-63 Acylglycerol kinase, mitochondrial OS=Homo sapiens GN=AGK PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain -- -- GO:0016301 kinase activity -- -- KOG4435 Predicted lipid kinase Cluster-8309.31479 BF_2 1402.15 35.00 1963 91082963 XP_973727.1 1606 7.6e-176 PREDICTED: dnaJ homolog subfamily B member 11 [Tribolium castaneum] 820854133 XM_003695391.2 191 5.88848e-93 PREDICTED: Apis florea dnaJ homolog subfamily B member 11 (LOC100870508), mRNA K09517 DNAJB11 DnaJ homolog subfamily B member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09517 Q5RAJ6 1131 3.7e-122 DnaJ homolog subfamily B member 11 OS=Pongo abelii GN=DNAJB11 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.31482 BF_2 169.82 2.15 3589 642918856 XP_008191616.1 1737 8.9e-191 PREDICTED: pericentriolar material 1 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76329 142 3.3e-07 Interaptin OS=Dictyostelium discoideum GN=abpD PE=1 SV=1 PF01414//PF04434 Delta serrate ligand//SWIM zinc finger GO:0007154 cell communication GO:0008270 zinc ion binding GO:0016020 membrane -- -- Cluster-8309.31483 BF_2 72.00 1.55 2231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31484 BF_2 52.00 11.69 473 642913166 XP_008201418.1 283 4.7e-23 PREDICTED: 39S ribosomal protein L33, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02913 RP-L33, MRPL33, rpmG large subunit ribosomal protein L33 http://www.genome.jp/dbget-bin/www_bget?ko:K02913 Q7PYH1 243 8.4e-20 39S ribosomal protein L33, mitochondrial OS=Anopheles gambiae GN=mRpL33 PE=3 SV=2 PF00471 Ribosomal protein L33 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.31487 BF_2 342.98 2.61 5784 642921963 XP_008192963.1 2834 0.0e+00 PREDICTED: uncharacterized protein LOC658725 [Tribolium castaneum]>gi|270007382|gb|EFA03830.1| hypothetical protein TcasGA2_TC013946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.31488 BF_2 831.56 24.57 1703 91088443 XP_968621.1 1541 2.3e-168 PREDICTED: coiled-coil domain-containing protein 47 [Tribolium castaneum]>gi|270011745|gb|EFA08193.1| hypothetical protein TcasGA2_TC005820 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC50 931 5.0e-99 Coiled-coil domain-containing protein 47 OS=Bos taurus GN=CCDC47 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2357 Uncharacterized conserved protein Cluster-8309.31489 BF_2 1185.94 33.12 1785 478251900 ENN72338.1 2230 3.0e-248 hypothetical protein YQE_10973, partial [Dendroctonus ponderosae]>gi|546680877|gb|ERL91063.1| hypothetical protein D910_08405 [Dendroctonus ponderosae] 170071688 XM_001869946.1 223 8.69425e-111 Culex quinquefasciatus dihydrolipoamide dehydrogenase, mRNA K00382 DLD, lpd, pdhD dihydrolipoamide dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00382 P09623 1847 3.2e-205 Dihydrolipoyl dehydrogenase, mitochondrial OS=Sus scrofa GN=DLD PE=1 SV=1 PF02852//PF07992//PF01494//PF00070 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0071949//GO:0016491 FAD binding//oxidoreductase activity -- -- KOG1335 Dihydrolipoamide dehydrogenase Cluster-8309.31490 BF_2 874.13 45.55 1090 91077352 XP_975026.1 692 4.0e-70 PREDICTED: V-type proton ATPase 21 kDa proteolipid subunit [Tribolium castaneum]>gi|642913832|ref|XP_008201179.1| PREDICTED: V-type proton ATPase 21 kDa proteolipid subunit [Tribolium castaneum]>gi|270002761|gb|EEZ99208.1| VhaPPA1-1 [Tribolium castaneum] -- -- -- -- -- K03661 ATPeV0B, ATP6F V-type H+-transporting ATPase 21kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03661 Q91V37 478 1.1e-46 V-type proton ATPase 21 kDa proteolipid subunit OS=Mus musculus GN=Atp6v0b PE=1 SV=1 PF00137 ATP synthase subunit C GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.31493 BF_2 52.59 0.62 3819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm -- -- Cluster-8309.31494 BF_2 8.00 1.20 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31497 BF_2 96.24 0.71 5971 642938278 XP_008192712.1 3281 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 958 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.3e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF12142//PF00069//PF07714 Polyphenol oxidase middle domain//Protein kinase domain//Protein tyrosine kinase GO:0006118//GO:0006570//GO:0055114//GO:0006468 obsolete electron transport//tyrosine metabolic process//oxidation-reduction process//protein phosphorylation GO:0005524//GO:0004672//GO:0004097 ATP binding//protein kinase activity//catechol oxidase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.31498 BF_2 4.00 0.34 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31499 BF_2 41.53 1.15 1794 554879053 XP_005949345.1 151 3.6e-07 PREDICTED: low-density lipoprotein receptor-related protein 2-like [Haplochromis burtoni] -- -- -- -- -- -- -- -- -- P98164 140 2.8e-07 Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens GN=LRP2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.31500 BF_2 542.00 33.25 969 91078296 XP_972110.1 751 5.2e-77 PREDICTED: presqualene diphosphate phosphatase [Tribolium castaneum]>gi|270003950|gb|EFA00398.1| hypothetical protein TcasGA2_TC003248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TZ07 224 2.7e-17 Presqualene diphosphate phosphatase OS=Danio rerio GN=ppapdc2 PE=2 SV=1 PF01899 Na+/H+ ion antiporter subunit GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG4268 Uncharacterized conserved protein containing PAP2 domain Cluster-8309.31501 BF_2 301.73 13.21 1243 478259624 ENN79477.1 979 2.4e-103 hypothetical protein YQE_04121, partial [Dendroctonus ponderosae] -- -- -- -- -- K13982 DDX4, VASA probable ATP-dependent RNA helicase DDX4 http://www.genome.jp/dbget-bin/www_bget?ko:K13982 P09052 700 2.2e-72 ATP-dependent RNA helicase vasa, isoform A OS=Drosophila melanogaster GN=vas PE=1 SV=3 PF01297//PF06862 Zinc-uptake complex component A periplasmic//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 GO:0030001 metal ion transport GO:0046872 metal ion binding GO:0005634 nucleus KOG0335 ATP-dependent RNA helicase Cluster-8309.31504 BF_2 1612.39 22.25 3319 478256311 ENN76501.1 492 1.9e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31505 BF_2 5.00 0.49 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31506 BF_2 28.84 0.34 3873 642921818 XP_008199331.1 2491 3.6e-278 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] 665798678 XM_008549002.1 56 1.30268e-17 PREDICTED: Microplitis demolitor vitamin K-dependent gamma-carboxylase (LOC103571031), transcript variant X3, mRNA K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 1371 1.1e-149 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.31510 BF_2 3.94 1.43 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31511 BF_2 343.00 26.38 831 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31512 BF_2 41.06 2.67 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31513 BF_2 1060.55 14.01 3454 642935527 XP_973346.2 2065 8.0e-229 PREDICTED: phosphoacetylglucosamine mutase [Tribolium castaneum] 629692694 XM_007813448.1 35 5.47588e-06 Metarhizium acridum CQMa 102 N-acetylglucosamine-phosphate mutase partial mRNA K01836 E5.4.2.3 phosphoacetylglucosamine mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01836 O95394 1416 5.9e-155 Phosphoacetylglucosamine mutase OS=Homo sapiens GN=PGM3 PE=1 SV=1 PF00408//PF02879//PF02878//PF02880//PF05698 Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Bacterial trigger factor protein (TF) C-terminus GO:0015031//GO:0005975//GO:0006457//GO:0071704 protein transport//carbohydrate metabolic process//protein folding//organic substance metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG2537 Phosphoglucomutase/phosphomannomutase Cluster-8309.31519 BF_2 2387.00 12.82 8077 546673207 ERL84861.1 1263 1.8e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.2e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF04632//PF01066//PF05529//PF00437//PF07989//PF03193//PF00005//PF04548//PF02183//PF15458//PF17078//PF06156//PF04111//PF06005//PF01166//PF03824//PF00503 Fusaric acid resistance protein family//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like//Type II/IV secretion system protein//Centrosomin N-terminal motif 1//Protein of unknown function, DUF258//ABC transporter//AIG1 family//Homeobox associated leucine zipper//Nineteen complex-related protein 2//SWI5-dependent HO expression protein 3//Protein of unknown function (DUF972)//Autophagy protein Apg6//Protein of unknown function (DUF904)//TSC-22/dip/bun family//High-affinity nickel-transport protein//G-protein alpha subunit GO:0000917//GO:0008654//GO:0043093//GO:0007165//GO:0006914//GO:0006886//GO:0006810//GO:0007186//GO:0000390//GO:0006355//GO:0015675//GO:0051028//GO:0048309//GO:0035444//GO:0006260 barrier septum assembly//phospholipid biosynthetic process//FtsZ-dependent cytokinesis//signal transduction//autophagy//intracellular protein transport//transport//G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//regulation of transcription, DNA-templated//nickel cation transport//mRNA transport//endoplasmic reticulum inheritance//nickel cation transmembrane transport//DNA replication GO:0016780//GO:0015099//GO:0005525//GO:0004871//GO:0043565//GO:0046872//GO:0005524//GO:0031683//GO:0003924//GO:0019001//GO:0016887//GO:0003700 phosphotransferase activity, for other substituted phosphate groups//nickel cation transmembrane transporter activity//GTP binding//signal transducer activity//sequence-specific DNA binding//metal ion binding//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//guanyl nucleotide binding//ATPase activity//transcription factor activity, sequence-specific DNA binding GO:0005886//GO:0005783//GO:0016020//GO:0005815//GO:0016021//GO:0005737//GO:0071008//GO:0005667 plasma membrane//endoplasmic reticulum//membrane//microtubule organizing center//integral component of membrane//cytoplasm//U2-type post-mRNA release spliceosomal complex//transcription factor complex KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.31521 BF_2 2206.01 27.72 3616 91093755 XP_969513.1 2176 1.1e-241 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270012977|gb|EFA09425.1| hypothetical protein TcasGA2_TC010636 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 O15254 1461 3.7e-160 Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens GN=ACOX3 PE=1 SV=2 PF01756//PF00107//PF07716//PF05139//PF00441//PF07544//PF02770 Acyl-CoA oxidase//Zinc-binding dehydrogenase//Basic region leucine zipper//Erythromycin esterase//Acyl-CoA dehydrogenase, C-terminal domain//RNA polymerase II transcription mediator complex subunit 9//Acyl-CoA dehydrogenase, middle domain GO:0006637//GO:0055114//GO:0006355//GO:0006118//GO:0006357//GO:0006635//GO:0046677//GO:0006631 acyl-CoA metabolic process//oxidation-reduction process//regulation of transcription, DNA-templated//obsolete electron transport//regulation of transcription from RNA polymerase II promoter//fatty acid beta-oxidation//response to antibiotic//fatty acid metabolic process GO:0003995//GO:0003700//GO:0016627//GO:0043565//GO:0001104//GO:0003997 acyl-CoA dehydrogenase activity//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//sequence-specific DNA binding//RNA polymerase II transcription cofactor activity//acyl-CoA oxidase activity GO:0005667//GO:0005777//GO:0016592 transcription factor complex//peroxisome//mediator complex KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.31524 BF_2 163.00 1.45 4999 642921594 XP_008192439.1 1804 2.1e-198 PREDICTED: protein xmas-2 [Tribolium castaneum]>gi|270006333|gb|EFA02781.1| hypothetical protein TcasGA2_TC008518 [Tribolium castaneum] 170067749 XM_001868570.1 97 2.72155e-40 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q9U3V9 1089 7.1e-117 Protein xmas-2 OS=Drosophila melanogaster GN=xmas-2 PE=1 SV=3 PF09468 Ydr279p protein family (RNase H2 complex component) -- -- -- -- GO:0005634 nucleus KOG1860 Nuclear protein export factor Cluster-8309.31525 BF_2 512.32 15.31 1687 642918520 XP_008191507.1 692 6.3e-70 PREDICTED: uncharacterized protein CG1161 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNA4 351 9.0e-32 Uncharacterized protein CG1161 OS=Drosophila melanogaster GN=CG1161 PE=3 SV=1 PF01708//PF05434 Geminivirus putative movement protein//TMEM9 GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane KOG4007 Uncharacterized conserved protein Cluster-8309.31529 BF_2 34.27 1.10 1593 546681588 ERL91652.1 2048 3.4e-227 hypothetical protein D910_08980 [Dendroctonus ponderosae] 642933909 XM_966503.2 333 5.49665e-172 PREDICTED: Tribolium castaneum pontin (LOC660254), mRNA K04499 RUVBL1, RVB1, INO80H RuvB-like protein 1 (pontin 52) http://www.genome.jp/dbget-bin/www_bget?ko:K04499 Q0IFL2 1858 1.5e-206 RuvB-like helicase 1 OS=Aedes aegypti GN=pont PE=3 SV=1 PF00004//PF00158//PF06068//PF01057//PF05496//PF03796//PF07728//PF14532//PF01695//PF00910//PF02367//PF04851//PF06414//PF02562 ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//DnaB-like helicase C terminal domain//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//RNA helicase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Type III restriction enzyme, res subunit//Zeta toxin//PhoH-like protein GO:0002949//GO:0006310//GO:0006281//GO:0019079//GO:0006260//GO:0006355 tRNA threonylcarbamoyladenosine modification//DNA recombination//DNA repair//viral genome replication//DNA replication//regulation of transcription, DNA-templated GO:0003677//GO:0003678//GO:0003723//GO:0009378//GO:0003724//GO:0008134//GO:0016787//GO:0005524//GO:0016301//GO:0016887 DNA binding//DNA helicase activity//RNA binding//four-way junction helicase activity//RNA helicase activity//transcription factor binding//hydrolase activity//ATP binding//kinase activity//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG1942 DNA helicase, TBP-interacting protein Cluster-8309.3153 BF_2 108.05 0.52 9055 642911448 XP_008199427.1 3581 0.0e+00 PREDICTED: atrial natriuretic peptide-converting enzyme-like [Tribolium castaneum] 642911447 XM_008201205.1 584 0 PREDICTED: Tribolium castaneum atrial natriuretic peptide-converting enzyme-like (LOC661781), mRNA K09614 CORIN corin http://www.genome.jp/dbget-bin/www_bget?ko:K09614 P98073 535 2.2e-52 Enteropeptidase OS=Homo sapiens GN=TMPRSS15 PE=1 SV=3 PF00057//PF01392//PF00089//PF15494 Low-density lipoprotein receptor domain class A//Fz domain//Trypsin//Scavenger receptor cysteine-rich domain GO:0006508 proteolysis GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.31530 BF_2 1517.66 31.09 2329 189238821 XP_968538.2 947 2.3e-99 PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|642927448|ref|XP_008195277.1| PREDICTED: heterogeneous nuclear ribonucleoprotein K isoform X1 [Tribolium castaneum]>gi|270010156|gb|EFA06604.1| hypothetical protein TcasGA2_TC009519 [Tribolium castaneum] -- -- -- -- -- K12886 HNRNPK heterogeneous nuclear ribonucleoprotein K http://www.genome.jp/dbget-bin/www_bget?ko:K12886 Q5ZIQ3 455 1.1e-43 Heterogeneous nuclear ribonucleoprotein K OS=Gallus gallus GN=HNRNPK PE=2 SV=1 PF07650//PF13184//PF13014//PF00013 KH domain//NusA-like KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2192 PolyC-binding hnRNP-K protein HRB57A/hnRNP, contains KH domain Cluster-8309.31532 BF_2 618.43 25.64 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31537 BF_2 100.00 4.90 1141 478263036 ENN81436.1 706 1.0e-71 hypothetical protein YQE_02129, partial [Dendroctonus ponderosae] -- -- -- -- -- K13154 ZCRB1 U11/U12 small nuclear ribonucleoprotein 31 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13154 Q6DJI9 532 6.2e-53 Zinc finger CCHC-type and RNA-binding motif-containing protein 1 OS=Xenopus laevis GN=zcrb1 PE=2 SV=1 PF00076//PF16367//PF00098 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG0118 FOG: RRM domain Cluster-8309.31538 BF_2 26.78 0.35 3484 642931800 XP_008196735.1 1799 5.6e-198 PREDICTED: probable tRNA (guanine(26)-N(2))-dimethyltransferase [Tribolium castaneum] 805826840 XM_012297893.1 36 1.53586e-06 PREDICTED: Megachile rotundata probable tRNA (guanine(26)-N(2))-dimethyltransferase (LOC105664233), mRNA K00555 TRMT1, trm1 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00555 Q9VK89 1497 2.4e-164 Probable tRNA (guanine(26)-N(2))-dimethyltransferase OS=Drosophila melanogaster GN=CG6388 PE=2 SV=1 PF02005//PF05958//PF03602//PF05175 N2,N2-dimethylguanosine tRNA methyltransferase//tRNA (Uracil-5-)-methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain GO:0008033//GO:0006396//GO:0009451//GO:0031167 tRNA processing//RNA processing//RNA modification//rRNA methylation GO:0004809//GO:0008168//GO:0008173//GO:0003723 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//RNA methyltransferase activity//RNA binding -- -- KOG1253 tRNA methyltransferase Cluster-8309.31539 BF_2 557.00 113.66 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31540 BF_2 1880.77 34.22 2586 642928778 XP_008195558.1 2110 3.6e-234 PREDICTED: hexosaminidase 1 isoform X2 [Tribolium castaneum] 462295813 APGK01052604.1 77 1.83594e-29 Dendroctonus ponderosae Seq01052614, whole genome shotgun sequence K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49010 1696 1.5e-187 Chitooligosaccharidolytic beta-N-acetylglucosaminidase OS=Bombyx mori PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.31541 BF_2 1062.57 10.86 4382 91095065 XP_972609.1 4037 0.0e+00 PREDICTED: IQ motif and SEC7 domain-containing protein 1 isoform X2 [Tribolium castaneum]>gi|270014755|gb|EFA11203.1| hypothetical protein TcasGA2_TC005167 [Tribolium castaneum] 641661643 XM_001945108.3 182 1.33636e-87 PREDICTED: Acyrthosiphon pisum IQ motif and SEC7 domain-containing protein 1 (LOC100162626), transcript variant X2, mRNA K12495 IQSEC IQ motif and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12495 Q6DN90 1206 1.7e-130 IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens GN=IQSEC1 PE=1 SV=1 PF01369//PF04977//PF00612 Sec7 domain//Septum formation initiator//IQ calmodulin-binding motif GO:0007049//GO:0043087//GO:0032012 cell cycle//regulation of GTPase activity//regulation of ARF protein signal transduction GO:0005515//GO:0005086//GO:0005543 protein binding//ARF guanyl-nucleotide exchange factor activity//phospholipid binding GO:0005622 intracellular KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain Cluster-8309.31542 BF_2 250.69 5.82 2089 189241787 XP_969759.2 2313 8.4e-258 PREDICTED: cell division cycle protein 16 homolog [Tribolium castaneum] -- -- -- -- -- K03353 APC6, CDC16 anaphase-promoting complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03353 Q13042 1075 1.2e-115 Cell division cycle protein 16 homolog OS=Homo sapiens GN=CDC16 PE=1 SV=2 PF04097//PF13181//PF13174//PF04049//PF13374//PF00515//PF13371//PF13414//PF13176 Nup93/Nic96//Tetratricopeptide repeat//Tetratricopeptide repeat//Anaphase promoting complex subunit 8 / Cdc23//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006810//GO:0030071 transport//regulation of mitotic metaphase/anaphase transition GO:0005515 protein binding GO:0005680//GO:0005643 anaphase-promoting complex//nuclear pore KOG1173 Anaphase-promoting complex (APC), Cdc16 subunit Cluster-8309.31544 BF_2 4.44 0.52 644 642932806 XP_008196991.1 535 3.8e-52 PREDICTED: myosin heavy chain, non-muscle isoform X2 [Tribolium castaneum] -- -- -- -- -- K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q61879 419 4.5e-40 Myosin-10 OS=Mus musculus GN=Myh10 PE=1 SV=2 PF00063//PF02736 Myosin head (motor domain)//Myosin N-terminal SH3-like domain -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.31546 BF_2 33.30 0.94 1764 642925135 XP_008194182.1 316 2.6e-26 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31548 BF_2 56.55 0.34 7145 270008035 EFA04483.1 2949 0.0e+00 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 909 7.5e-96 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF10280//PF00621//PF14604//PF00018 Mediator complex protein//RhoGEF domain//Variant SH3 domain//SH3 domain GO:0006357//GO:0035023//GO:0043087 regulation of transcription from RNA polymerase II promoter//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515//GO:0001104 Rho guanyl-nucleotide exchange factor activity//protein binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2070 Guanine nucleotide exchange factor Cluster-8309.31549 BF_2 12.91 0.34 1860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.31551 BF_2 1200.82 9.35 5657 478252773 ENN73166.1 3703 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1864 1.1e-206 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31552 BF_2 1799.14 9.37 8318 478252773 ENN73166.1 3703 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1864 1.6e-206 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF16965//PF02209 Ceramide synthase regulator//Villin headpiece domain GO:0007010//GO:0006874 cytoskeleton organization//cellular calcium ion homeostasis GO:0003779//GO:0030234 actin binding//enzyme regulator activity GO:0030176 integral component of endoplasmic reticulum membrane KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31554 BF_2 80.41 0.37 9444 478252773 ENN73166.1 3484 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1831 1.2e-202 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31555 BF_2 782.42 6.84 5072 478252773 ENN73166.1 3672 0.0e+00 hypothetical protein YQE_10221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10369 SVIL supervillin http://www.genome.jp/dbget-bin/www_bget?ko:K10369 Q8K4L3 1864 9.8e-207 Supervillin OS=Mus musculus GN=Svil PE=1 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG0445 Actin regulatory protein supervillin (gelsolin/villin family) Cluster-8309.31556 BF_2 56.00 0.63 4018 270297188 NP_001161909.1 1041 5.1e-110 cuticular protein analogous to peritrophins 3-A2 precursor [Tribolium castaneum]>gi|268309020|gb|ACY95476.1| cuticular protein analogous to peritrophins 3-A2 [Tribolium castaneum]>gi|270000883|gb|EEZ97330.1| hypothetical protein TcasGA2_TC011141 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76217 139 8.2e-07 Peritrophin-1 OS=Anopheles gambiae GN=Aper1 PE=2 SV=2 PF06941//PF01607 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)//Chitin binding Peritrophin-A domain GO:0009264//GO:0006030 deoxyribonucleotide catabolic process//chitin metabolic process GO:0008253//GO:0008061 5'-nucleotidase activity//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.31558 BF_2 8955.84 56.67 6898 270008035 EFA04483.1 2949 0.0e+00 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 909 7.3e-96 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF10280//PF00621//PF14604//PF00018 Mediator complex protein//RhoGEF domain//Variant SH3 domain//SH3 domain GO:0043087//GO:0035023//GO:0006357 regulation of GTPase activity//regulation of Rho protein signal transduction//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0005089//GO:0001104 protein binding//Rho guanyl-nucleotide exchange factor activity//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2070 Guanine nucleotide exchange factor Cluster-8309.31559 BF_2 1018.15 6.21 7148 642927132 XP_008195151.1 2005 1.5e-221 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 4.06725e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 1.8e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF13014//PF13184//PF00013//PF07650//PF10192 KH domain//NusA-like KH domain//KH domain//KH domain//Rhodopsin-like GPCR transmembrane domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.31560 BF_2 17.00 10.54 350 642925135 XP_008194182.1 228 8.3e-17 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31562 BF_2 173.18 3.08 2643 91081187 XP_975598.1 1544 1.6e-168 PREDICTED: GAS2-like protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43903 349 2.4e-31 Growth arrest-specific protein 2 OS=Homo sapiens GN=GAS2 PE=1 SV=1 PF00307//PF02187 Calponin homology (CH) domain//Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.31566 BF_2 228.15 20.75 747 642920229 XP_008192257.1 440 4.6e-41 PREDICTED: 60S ribosomal protein L10a isoform X1 [Tribolium castaneum] 315115352 HQ424705.1 140 4.88501e-65 Euphydryas aurinia ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 403 3.7e-38 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00468 Ribosomal protein L34 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1570 60S ribosomal protein L10A Cluster-8309.31568 BF_2 1399.60 16.27 3886 189240214 XP_001807190.1 826 4.2e-85 PREDICTED: uncharacterized protein LOC100142448 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01445//PF08826//PF01166 Viral small hydrophobic protein//DMPK coiled coil domain like//TSC-22/dip/bun family GO:0006355//GO:0016310//GO:0009069//GO:0006468 regulation of transcription, DNA-templated//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004674//GO:0003700//GO:0005524 protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//ATP binding GO:0016020//GO:0005667 membrane//transcription factor complex -- -- Cluster-8309.3157 BF_2 103.29 1.18 3963 642910681 XP_008200058.1 923 2.4e-96 PREDICTED: Kv channel-interacting protein 4-like isoform X2 [Tribolium castaneum] 642910680 XM_008201836.1 229 9.01025e-114 PREDICTED: Tribolium castaneum Kv channel-interacting protein 4-like (LOC657688), transcript variant X2, mRNA -- -- -- -- Q99MG9 580 5.9e-58 Kv channel-interacting protein 4 OS=Rattus norvegicus GN=Kcnip4 PE=1 SV=1 PF12763//PF10591//PF13833//PF13405//PF03802//PF13499//PF13202//PF13762//PF00036 Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase//EF-hand domain pair//EF hand//Mitochondrial splicing apparatus component//EF hand GO:0051191//GO:0000372//GO:0007165 prosthetic group biosynthetic process//Group I intron splicing//signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0030529//GO:0005578 intracellular ribonucleoprotein complex//proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.31570 BF_2 491.00 22.83 1187 478254407 ENN74659.1 543 8.4e-53 hypothetical protein YQE_08776, partial [Dendroctonus ponderosae]>gi|546682348|gb|ERL92296.1| hypothetical protein D910_09613 [Dendroctonus ponderosae] -- -- -- -- -- K07554 ATPeF0S, ATP5S ATP synthase, H+ transporting, mitochondrial F0 complex, subunit s http://www.genome.jp/dbget-bin/www_bget?ko:K07554 P22027 343 5.3e-31 ATP synthase subunit s, mitochondrial OS=Bos taurus GN=ATP5S PE=1 SV=2 PF10152 Predicted coiled-coil domain-containing protein (DUF2360) -- -- -- -- GO:0071203 WASH complex KOG3864 Uncharacterized conserved protein Cluster-8309.31572 BF_2 563.58 9.20 2849 642934752 XP_008197796.1 1257 3.2e-135 PREDICTED: transmembrane protein 129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IJ33 730 1.7e-75 E3 ubiquitin-protein ligase TM129 OS=Xenopus tropicalis GN=tmem129 PE=2 SV=1 PF00181//PF05203 Ribosomal Proteins L2, RNA binding domain//Hom_end-associated Hint GO:0042254//GO:0006412//GO:0030908 ribosome biogenesis//translation//protein splicing GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.31574 BF_2 3161.07 74.34 2066 642937320 XP_008198786.1 1306 4.9e-141 PREDICTED: venom carboxylesterase-6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 970 1.8e-103 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.31576 BF_2 621.12 5.30 5189 642919375 XP_008191845.1 3545 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 6.1e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF02480//PF01325//PF13895//PF00069//PF07714 Alphaherpesvirus glycoprotein E//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0003677//GO:0005524 protein kinase activity//protein binding//DNA binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.31577 BF_2 19.00 1.01 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00387 Phosphatidylinositol-specific phospholipase C, Y domain GO:0035556//GO:0006629//GO:0007165//GO:0046339//GO:0009395 intracellular signal transduction//lipid metabolic process//signal transduction//diacylglycerol metabolic process//phospholipid catabolic process GO:0004435 phosphatidylinositol phospholipase C activity -- -- -- -- Cluster-8309.31578 BF_2 547.00 73.37 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31583 BF_2 1800.17 21.51 3788 478260934 ENN80551.1 251 1.9e-18 hypothetical protein YQE_03030, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09807//PF02234 Elongation complex protein 6//Cyclin-dependent kinase inhibitor GO:0045859//GO:0007050 regulation of protein kinase activity//cell cycle arrest GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634//GO:0033588 nucleus//Elongator holoenzyme complex -- -- Cluster-8309.31586 BF_2 252.91 3.53 3285 642921092 XP_008192688.1 1903 4.6e-210 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q9VDR1 538 3.6e-53 Mediator of RNA polymerase II transcription subunit 25 OS=Drosophila melanogaster GN=MED25 PE=2 SV=1 PF00643//PF09398 B-box zinc finger//FOP N terminal dimerisation domain GO:0034453 microtubule anchoring GO:0008270 zinc ion binding GO:0005622//GO:0005815 intracellular//microtubule organizing center -- -- Cluster-8309.31589 BF_2 977.11 38.79 1341 189237761 XP_001812872.1 1398 6.8e-152 PREDICTED: probable tubulin polyglutamylase TTLL2 [Tribolium castaneum] -- -- -- -- -- K16600 TTLL2 tubulin polyglutamylase TTLL2 http://www.genome.jp/dbget-bin/www_bget?ko:K16600 Q9BWV7 553 2.7e-55 Probable tubulin polyglutamylase TTLL2 OS=Homo sapiens GN=TTLL2 PE=5 SV=3 PF01430//PF03133 Hsp33 protein//Tubulin-tyrosine ligase family GO:0006464//GO:0006457 cellular protein modification process//protein folding GO:0051082 unfolded protein binding GO:0005737 cytoplasm KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.31592 BF_2 40.14 0.39 4617 189239736 XP_001809239.1 672 3.6e-67 PREDICTED: uncharacterized protein LOC100141683 [Tribolium castaneum]>gi|270011260|gb|EFA07708.1| hypothetical protein TcasGA2_TC002185 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31593 BF_2 161.95 3.52 2214 189239736 XP_001809239.1 869 2.5e-90 PREDICTED: uncharacterized protein LOC100141683 [Tribolium castaneum]>gi|270011260|gb|EFA07708.1| hypothetical protein TcasGA2_TC002185 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31596 BF_2 345.42 8.08 2076 91082807 XP_968134.1 1136 2.5e-121 PREDICTED: general transcription factor IIF subunit 2 [Tribolium castaneum]>gi|270007102|gb|EFA03550.1| hypothetical protein TcasGA2_TC013555 [Tribolium castaneum] 755881816 XM_005185870.2 95 1.44825e-39 PREDICTED: Musca domestica general transcription factor IIF subunit 2 (LOC101901202), mRNA K03139 TFIIF2, GTF2F2, TFG2 transcription initiation factor TFIIF subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03139 P41900 871 5.6e-92 General transcription factor IIF subunit 2 OS=Drosophila melanogaster GN=TfIIFbeta PE=2 SV=2 PF02270 Transcription initiation factor IIF, beta subunit GO:0006367//GO:0006366 transcription initiation from RNA polymerase II promoter//transcription from RNA polymerase II promoter GO:0005524//GO:0003824 ATP binding//catalytic activity GO:0005674 transcription factor TFIIF complex KOG2905 Transcription initiation factor IIF, small subunit (RAP30) Cluster-8309.31597 BF_2 235.11 0.94 10735 642938167 XP_008190994.1 245 2.7e-17 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652//PF13414//PF00802 Methuselah N-terminus//TPR repeat//Pneumovirus attachment glycoprotein G GO:0007186//GO:0006950 G-protein coupled receptor signaling pathway//response to stress GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0055036 virion membrane -- -- Cluster-8309.31598 BF_2 749.36 2.80 11488 642938167 XP_008190994.1 647 7.1e-64 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NQ0 322 1.4e-27 G-protein coupled receptor Mth2 OS=Drosophila simulans GN=mth2 PE=3 SV=1 PF00001//PF13414//PF00802//PF00002 7 transmembrane receptor (rhodopsin family)//TPR repeat//Pneumovirus attachment glycoprotein G//7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016021//GO:0055036 integral component of membrane//virion membrane -- -- Cluster-8309.31599 BF_2 203.20 2.57 3590 242018392 XP_002429661.1 645 3.8e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 4.4e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.3160 BF_2 2.00 0.36 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31604 BF_2 35.42 1.01 1760 642929787 XP_008195976.1 628 1.7e-62 PREDICTED: elongation of very long chain fatty acids protein AAEL008004-like [Tribolium castaneum]>gi|270009529|gb|EFA05977.1| hypothetical protein TcasGA2_TC008803 [Tribolium castaneum] -- -- -- -- -- K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 Q1HRV8 462 1.3e-44 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.31605 BF_2 347.50 7.66 2184 642937984 XP_008199157.1 325 2.9e-27 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.31606 BF_2 22.47 0.78 1499 546676446 ERL87451.1 220 3.0e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.31607 BF_2 199.03 7.12 1457 642921101 XP_975194.2 1033 1.6e-109 PREDICTED: something about silencing protein 10 [Tribolium castaneum] -- -- -- -- -- K14767 UTP3, SAS10 U3 small nucleolar RNA-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14767 Q9I7W5 561 3.5e-56 Something about silencing protein 10 OS=Drosophila melanogaster GN=Sas10 PE=1 SV=2 PF03165 MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3118 Disrupter of silencing SAS10 Cluster-8309.31608 BF_2 110.12 1.60 3175 642924616 XP_008194365.1 1944 7.8e-215 PREDICTED: uncharacterized protein LOC663601 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 4.4e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.31611 BF_2 65.05 0.82 3605 91089287 XP_971047.1 591 6.9e-58 PREDICTED: derlin-2 [Tribolium castaneum]>gi|270012498|gb|EFA08946.1| hypothetical protein TcasGA2_TC006653 [Tribolium castaneum] 762105781 XR_901040.1 39 3.41697e-08 PREDICTED: Crassostrea gigas derlin-2-like (LOC105333927), transcript variant X2, misc_RNA K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q8BNI4 530 3.4e-52 Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.31612 BF_2 80.37 2.80 1490 642925464 XP_008194565.1 397 8.9e-36 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome -- -- Cluster-8309.31613 BF_2 21.70 0.31 3228 642919300 XP_008191816.1 1453 6.9e-158 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64634 648 6.3e-66 UDP-glucuronosyltransferase 1-8 OS=Rattus norvegicus GN=Ugt1a8 PE=2 SV=1 PF04101//PF00201//PF02419//PF13409 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//PsbL protein//Glutathione S-transferase, N-terminal domain GO:0015979//GO:0008152 photosynthesis//metabolic process GO:0005515//GO:0016758 protein binding//transferase activity, transferring hexosyl groups GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.31616 BF_2 203.88 18.23 755 642925667 XP_008194662.1 866 1.9e-90 PREDICTED: uncharacterized protein LOC663019 isoform X2 [Tribolium castaneum]>gi|270008899|gb|EFA05347.1| hypothetical protein TcasGA2_TC015511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31618 BF_2 64.26 3.22 1123 642925667 XP_008194662.1 838 4.9e-87 PREDICTED: uncharacterized protein LOC663019 isoform X2 [Tribolium castaneum]>gi|270008899|gb|EFA05347.1| hypothetical protein TcasGA2_TC015511 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3162 BF_2 3.00 1.34 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31620 BF_2 464.30 1.84 10864 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.61558e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF00069//PF09162//PF07714//PF04043//PF01059 Protein kinase domain//Tap, RNA-binding//Protein tyrosine kinase//Plant invertase/pectin methylesterase inhibitor//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006120//GO:0006468//GO:0006406//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//protein phosphorylation//mRNA export from nucleus//oxidation-reduction process GO:0003723//GO:0005524//GO:0004857//GO:0004672 RNA binding//ATP binding//enzyme inhibitor activity//protein kinase activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG3625 Alpha amylase Cluster-8309.31621 BF_2 4467.37 20.78 9280 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.37922e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF09162//PF04043 Tap, RNA-binding//Plant invertase/pectin methylesterase inhibitor GO:0006406 mRNA export from nucleus GO:0003723//GO:0004857 RNA binding//enzyme inhibitor activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG3625 Alpha amylase Cluster-8309.31622 BF_2 2058.52 30.54 3107 264667361 ACY71266.1 379 2.3e-33 ribosomal protein S25 [Chrysomela tremula] 525546292 KC480143.1 89 4.71549e-36 Dolomedes mizhoanus isolate DM-283 putative 40S ribosomal protein S25 gene, complete cds K02975 RP-S25e, RPS25 small subunit ribosomal protein S25e http://www.genome.jp/dbget-bin/www_bget?ko:K02975 Q962Q5 344 1.1e-30 40S ribosomal protein S25 OS=Spodoptera frugiperda GN=RpS25 PE=3 SV=1 PF15050//PF06632//PF09302 SCIMP protein//DNA double-strand break repair and V(D)J recombination protein XRCC4//XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0006302//GO:0006310 double-strand break repair//DNA recombination GO:0003677 DNA binding GO:0097197//GO:0016021//GO:0005634//GO:0001772 tetraspanin-enriched microdomain//integral component of membrane//nucleus//immunological synapse KOG1767 40S ribosomal protein S25 Cluster-8309.31623 BF_2 26.69 0.54 2354 478260742 ENN80421.1 1508 2.1e-164 hypothetical protein YQE_03169, partial [Dendroctonus ponderosae] 751463391 XM_011188291.1 142 1.22785e-65 PREDICTED: Bactrocera cucurbitae DNA-directed RNA polymerase II subunit RPB9 (LOC105214718), mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 744 3.4e-77 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF01096//PF06367//PF01667//PF06371//PF02150//PF06839//PF10508 Transcription factor S-II (TFIIS)//Diaphanous FH3 Domain//Ribosomal protein S27//Diaphanous GTPase-binding Domain//RNA polymerases M/15 Kd subunit//GRF zinc finger//Proteasome non-ATPase 26S subunit GO:0043248//GO:0042254//GO:0030036//GO:0006206//GO:0006351//GO:0016043//GO:0006144//GO:0006412 proteasome assembly//ribosome biogenesis//actin cytoskeleton organization//pyrimidine nucleobase metabolic process//transcription, DNA-templated//cellular component organization//purine nucleobase metabolic process//translation GO:0008270//GO:0003735//GO:0003899//GO:0003779//GO:0003676//GO:0017048//GO:0003677 zinc ion binding//structural constituent of ribosome//DNA-directed RNA polymerase activity//actin binding//nucleic acid binding//Rho GTPase binding//DNA binding GO:0005840//GO:0005622//GO:0005730 ribosome//intracellular//nucleolus KOG2691 RNA polymerase II subunit 9 Cluster-8309.31624 BF_2 558.57 9.54 2737 478249731 ENN70239.1 482 2.3e-45 hypothetical protein YQE_13023, partial [Dendroctonus ponderosae]>gi|546677413|gb|ERL88250.1| hypothetical protein D910_05638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y639 172 8.3e-11 Neuroplastin OS=Homo sapiens GN=NPTN PE=1 SV=2 PF13895//PF08120 Immunoglobulin domain//Tamulustoxin family GO:0009405//GO:0006810 pathogenesis//transport GO:0019870//GO:0005515 potassium channel inhibitor activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.31625 BF_2 5.00 2.27 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31626 BF_2 1986.63 12.37 7003 150170685 NP_001092812.1 1789 1.6e-196 methoprene-tolerant [Tribolium castaneum]>gi|149384881|gb|ABR25244.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- K13125 NOSIP nitric oxide synthase-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K13125 Q9VWV8 928 4.6e-98 Nitric oxide synthase-interacting protein homolog OS=Drosophila melanogaster GN=CG6179 PE=3 SV=1 PF00989//PF04564//PF00010//PF11789//PF08447 PAS fold//U-box domain//Helix-loop-helix DNA-binding domain//Zinc-finger of the MIZ type in Nse subunit//PAS fold GO:0016567//GO:0007165//GO:0006355 protein ubiquitination//signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0004842//GO:0046983//GO:0003677//GO:0003700//GO:0004871//GO:0008270 protein binding//ubiquitin-protein transferase activity//protein dimerization activity//DNA binding//transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm KOG3039 Uncharacterized conserved protein Cluster-8309.31629 BF_2 555.46 3.39 7145 150170685 NP_001092812.1 1789 1.7e-196 methoprene-tolerant [Tribolium castaneum]>gi|149384881|gb|ABR25244.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- K13125 NOSIP nitric oxide synthase-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K13125 Q9VWV8 589 9.6e-59 Nitric oxide synthase-interacting protein homolog OS=Drosophila melanogaster GN=CG6179 PE=3 SV=1 PF00010//PF11789//PF08447//PF04564//PF00989 Helix-loop-helix DNA-binding domain//Zinc-finger of the MIZ type in Nse subunit//PAS fold//U-box domain//PAS fold GO:0006355//GO:0016567//GO:0007165 regulation of transcription, DNA-templated//protein ubiquitination//signal transduction GO:0003700//GO:0004871//GO:0008270//GO:0005515//GO:0046983//GO:0004842//GO:0003677 transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding//protein binding//protein dimerization activity//ubiquitin-protein transferase activity//DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG3039 Uncharacterized conserved protein Cluster-8309.31632 BF_2 655.69 8.76 3418 332373100 AEE61691.1 1619 4.1e-177 unknown [Dendroctonus ponderosae] 632980128 XM_007908668.1 273 2.69392e-138 PREDICTED: Callorhinchus milii casein kinase 2, alpha 1 polypeptide (csnk2a1), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 3.1e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.31633 BF_2 66.81 0.85 3593 332373100 AEE61691.1 1682 2.1e-184 unknown [Dendroctonus ponderosae] 642911564 XM_008201254.1 402 0 PREDICTED: Tribolium castaneum casein kinase II subunit alpha-like (LOC660746), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 3.2e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.31634 BF_2 495.39 10.01 2358 91089723 XP_975024.1 1451 8.6e-158 PREDICTED: ATPase family AAA domain-containing protein 1-B [Tribolium castaneum]>gi|270011311|gb|EFA07759.1| hypothetical protein TcasGA2_TC005313 [Tribolium castaneum] 768421023 XM_011553001.1 182 7.14525e-88 PREDICTED: Plutella xylostella ATPase family AAA domain-containing protein 1-A (LOC105383005), mRNA -- -- -- -- Q503W7 1051 8.5e-113 ATPase family AAA domain-containing protein 1-B OS=Danio rerio GN=atad1b PE=2 SV=2 PF00910//PF02562//PF06414//PF02367//PF00004//PF07724//PF01695//PF07728//PF05496//PF06068//PF00158 RNA helicase//PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain GO:0006310//GO:0002949//GO:0006355//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair GO:0003724//GO:0009378//GO:0017111//GO:0003723//GO:0003678//GO:0016887//GO:0016301//GO:0005524//GO:0008134 RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//RNA binding//DNA helicase activity//ATPase activity//kinase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0737 AAA+-type ATPase Cluster-8309.31638 BF_2 24.03 0.45 2500 642914452 XP_008201682.1 1236 7.7e-133 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR37 322 3.1e-28 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31639 BF_2 219.93 3.09 3267 646710326 KDR15870.1 2260 1.8e-251 Dual serine/threonine and tyrosine protein kinase, partial [Zootermopsis nevadensis] -- -- -- -- -- K16288 RIPK5, DSTYK receptor-interacting serine/threonine-protein kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16288 Q1L6Q1 2010 7.4e-224 Dual serine/threonine and tyrosine protein kinase OS=Apis mellifera GN=DSTYK PE=2 SV=1 PF07714//PF06293//PF01442//PF00069//PF04614 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Apolipoprotein A1/A4/E domain//Protein kinase domain//Pex19 protein family GO:0042157//GO:0006869//GO:0006468 lipoprotein metabolic process//lipid transport//protein phosphorylation GO:0008289//GO:0005524//GO:0016773//GO:0004672 lipid binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0005777//GO:0016020//GO:0005576 peroxisome//membrane//extracellular region -- -- Cluster-8309.31642 BF_2 138.15 1.31 4686 -- -- -- -- -- 86515329 NM_001039401.1 63 2.02778e-21 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.31645 BF_2 142.99 2.05 3209 149588751 NP_001092296.1 2699 2.3e-302 fused lobes [Tribolium castaneum]>gi|642928772|ref|XP_008195555.1| PREDICTED: fused lobes isoform X1 [Tribolium castaneum]>gi|148611482|gb|ABQ95985.1| beta-N-acetylglucosaminidase FDL [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 1351 1.9e-147 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975//GO:0006027//GO:0001575//GO:0006040 carbohydrate metabolic process//glycosaminoglycan catabolic process//globoside metabolic process//amino sugar metabolic process GO:0004563//GO:0004553//GO:0043169 beta-N-acetylhexosaminidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.31646 BF_2 6310.05 42.59 6485 546685142 ERL94669.1 5047 0.0e+00 hypothetical protein D910_11944 [Dendroctonus ponderosae] 665804316 XM_008552072.1 92 2.12738e-37 PREDICTED: Microplitis demolitor neuroglian (LOC103573142), mRNA -- -- -- -- P20241 3670 0.0e+00 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF16656//PF02979//PF00041//PF13895//PF01108 Purple acid Phosphatase, N-terminal domain//Nitrile hydratase, alpha chain//Fibronectin type III domain//Immunoglobulin domain//Tissue factor GO:0019497//GO:0006771//GO:0006807 hexachlorocyclohexane metabolic process//riboflavin metabolic process//nitrogen compound metabolic process GO:0046914//GO:0003824//GO:0005515//GO:0003993//GO:0046872 transition metal ion binding//catalytic activity//protein binding//acid phosphatase activity//metal ion binding -- -- KOG3513 Neural cell adhesion molecule L1 Cluster-8309.31649 BF_2 61.84 0.74 3769 270002548 EEZ98995.1 917 1.1e-95 hypothetical protein TcasGA2_TC004856 [Tribolium castaneum] 482684012 XM_004444488.1 108 1.57132e-46 Drosophila pseudoobscura pseudoobscura GA30269, transcript variant G (Dpse\GA30269), partial mRNA K17338 REEP1_2_3_4 receptor expression-enhancing protein 1/2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17338 Q4KMI4 510 7.3e-50 Receptor expression-enhancing protein 2 OS=Danio rerio GN=reep2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.31651 BF_2 20.67 0.46 2173 478250135 ENN70638.1 167 6.1e-09 hypothetical protein YQE_12583, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31653 BF_2 682.36 14.21 2296 645001540 XP_008209577.1 493 1.0e-46 PREDICTED: uncharacterized protein LOC100119670 isoform X2 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q0P5B9 259 5.7e-21 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF00023//PF13606//PF06399 Ankyrin repeat//Ankyrin repeat//GTP cyclohydrolase I feedback regulatory protein (GFRP) GO:0009890 negative regulation of biosynthetic process GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.31655 BF_2 109.32 4.36 1336 642913826 XP_008201176.1 1005 2.5e-106 PREDICTED: microtubule-associated protein tau isoform X2 [Tribolium castaneum] -- -- -- -- -- K04380 MAPT, TAU microtubule-associated protein tau http://www.genome.jp/dbget-bin/www_bget?ko:K04380 P15146 324 9.6e-29 Microtubule-associated protein 2 OS=Rattus norvegicus GN=Map2 PE=1 SV=3 PF00418 Tau and MAP protein, tubulin-binding repeat -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex KOG2418 Microtubule-associated protein TAU Cluster-8309.31656 BF_2 90.00 1.90 2266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31657 BF_2 554.85 3.71 6538 332372760 AEE61522.1 509 4.0e-48 unknown [Dendroctonus ponderosae]>gi|478251664|gb|ENN72118.1| hypothetical protein YQE_11177, partial [Dendroctonus ponderosae]>gi|478262743|gb|ENN81274.1| hypothetical protein YQE_02310, partial [Dendroctonus ponderosae]>gi|546680918|gb|ERL91092.1| hypothetical protein D910_08434 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38718 366 6.3e-33 Mitochondrial pyruvate carrier 2 OS=Rattus norvegicus GN=Mpc2 PE=2 SV=1 PF02790//PF03650 Cytochrome C oxidase subunit II, transmembrane domain//Uncharacterised protein family (UPF0041) GO:0022900//GO:0006850 electron transport chain//mitochondrial pyruvate transport -- -- GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG1589 Uncharacterized conserved protein Cluster-8309.31658 BF_2 640.27 18.15 1763 478250970 ENN71454.1 937 2.6e-98 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 539 1.5e-53 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF04546//PF03153 Sigma-70, non-essential region//Transcription factor IIA, alpha/beta subunit GO:0006367//GO:0006352//GO:0006355 transcription initiation from RNA polymerase II promoter//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0016987//GO:0003677 transcription factor activity, sequence-specific DNA binding//sigma factor activity//DNA binding GO:0005672//GO:0005667 transcription factor TFIIA complex//transcription factor complex -- -- Cluster-8309.31660 BF_2 67.15 2.12 1614 91094373 XP_970761.1 1477 5.7e-161 PREDICTED: COP9 signalosome complex subunit 3 [Tribolium castaneum]>gi|270014914|gb|EFA11362.1| hypothetical protein TcasGA2_TC011519 [Tribolium castaneum] -- -- -- -- -- K12177 COPS3, CSN3 COP9 signalosome complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12177 Q6P2U9 1059 6.9e-114 COP9 signalosome complex subunit 3 OS=Danio rerio GN=cops3 PE=2 SV=1 PF01399//PF03791 PCI domain//KNOX2 domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus KOG2582 COP9 signalosome, subunit CSN3 Cluster-8309.31662 BF_2 1281.75 6.49 8554 642911061 XP_008200558.1 3598 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2982 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00813//PF00520 FliP family//Ion transport protein GO:0006811//GO:0009306//GO:0055085 ion transport//protein secretion//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.31663 BF_2 9.00 8.63 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11057 Cortexin of kidney -- -- -- -- GO:0031224 intrinsic component of membrane -- -- Cluster-8309.31665 BF_2 58.00 3.77 930 189237799 XP_001814012.1 437 1.3e-40 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 35A [Tribolium castaneum]>gi|270008127|gb|EFA04575.1| PNR-like protein [Tribolium castaneum] -- -- -- -- -- K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MVS5 256 5.1e-21 Polypeptide N-acetylgalactosaminyltransferase 35A OS=Drosophila melanogaster GN=Pgant35A PE=1 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus -- -- Cluster-8309.31666 BF_2 18.65 0.45 2003 478262459 ENN81130.1 869 2.2e-90 hypothetical protein YQE_02498, partial [Dendroctonus ponderosae]>gi|546672773|gb|ERL84529.1| hypothetical protein D910_01959 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T8L8 489 1.1e-47 Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Drosophila melanogaster GN=Alg10 PE=2 SV=1 PF04922 DIE2/ALG10 family GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0005789 endoplasmic reticulum membrane KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator Cluster-8309.31667 BF_2 437.93 11.37 1899 478262459 ENN81130.1 1176 5.3e-126 hypothetical protein YQE_02498, partial [Dendroctonus ponderosae]>gi|546672773|gb|ERL84529.1| hypothetical protein D910_01959 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T8L8 664 5.1e-68 Putative Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase OS=Drosophila melanogaster GN=Alg10 PE=2 SV=1 PF04922 DIE2/ALG10 family GO:0006488 dolichol-linked oligosaccharide biosynthetic process GO:0004583 dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity GO:0005789 endoplasmic reticulum membrane KOG2642 Alpha-1,2 glucosyltransferase/transcriptional activator Cluster-8309.31668 BF_2 280.48 13.38 1164 642920521 XP_008192385.1 794 6.4e-82 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] 195134144 XM_002011462.1 111 1.02175e-48 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q9VY99 582 1.0e-58 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF04952//PF07988//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//LMSTEN motif//Zinc carboxypeptidase GO:0006508//GO:0008152//GO:0006355 proteolysis//metabolic process//regulation of transcription, DNA-templated GO:0008270//GO:0016788//GO:0004181 zinc ion binding//hydrolase activity, acting on ester bonds//metallocarboxypeptidase activity -- -- KOG3641 Zinc carboxypeptidase Cluster-8309.31669 BF_2 86.95 5.58 939 642920521 XP_008192385.1 517 6.8e-50 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VY99 330 1.4e-29 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF07988 LMSTEN motif GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.31670 BF_2 315.85 4.03 3564 270011486 EFA07934.1 1655 2.9e-181 hypothetical protein TcasGA2_TC005515 [Tribolium castaneum] 755973707 XM_011308799.1 131 2.43279e-59 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 1129 1.2e-121 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF07714//PF00069//PF04196 Protein tyrosine kinase//Protein kinase domain//Bunyavirus RNA dependent RNA polymerase GO:0006468//GO:0006144//GO:0006351//GO:0019079 protein phosphorylation//purine nucleobase metabolic process//transcription, DNA-templated//viral genome replication GO:0004672//GO:0003968//GO:0005524 protein kinase activity//RNA-directed RNA polymerase activity//ATP binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.31671 BF_2 972.16 33.92 1486 642935823 XP_008198190.1 1395 1.7e-151 PREDICTED: serine--pyruvate aminotransferase, mitochondrial [Tribolium castaneum]>gi|270013276|gb|EFA09724.1| hypothetical protein TcasGA2_TC011857 [Tribolium castaneum] -- -- -- -- -- K00830 AGXT alanine-glyoxylate transaminase / serine-glyoxylate transaminase / serine-pyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00830 P31029 1051 5.4e-113 Serine--pyruvate aminotransferase, mitochondrial OS=Callithrix jacchus GN=AGXT PE=2 SV=1 PF01053//PF00282//PF04083 Cys/Met metabolism PLP-dependent enzyme//Pyridoxal-dependent decarboxylase conserved domain//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0019752//GO:0008152 lipid metabolic process//carboxylic acid metabolic process//metabolic process GO:0030170//GO:0003824//GO:0016831 pyridoxal phosphate binding//catalytic activity//carboxy-lyase activity -- -- KOG2862 Alanine-glyoxylate aminotransferase AGT1 Cluster-8309.31673 BF_2 544.25 9.64 2650 270014262 EFA10710.1 1378 2.8e-149 domino [Tribolium castaneum] 760445496 XM_011401515.1 99 1.10888e-41 Auxenochlorella protothecoides Helicase swr1 partial mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 667 3.2e-68 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.31675 BF_2 1339.01 6.97 8329 642930614 XP_008199194.1 1174 4.0e-125 PREDICTED: protein winged eye isoform X1 [Tribolium castaneum]>gi|642930616|ref|XP_967104.2| PREDICTED: protein winged eye isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3LHL9 631 1.5e-63 Protein winged eye OS=Drosophila melanogaster GN=wge PE=1 SV=1 PF13181//PF01426 Tetratricopeptide repeat//BAH domain -- -- GO:0005515//GO:0003682 protein binding//chromatin binding GO:0000785 chromatin -- -- Cluster-8309.31677 BF_2 1958.82 12.78 6700 642922229 XP_008193071.1 1543 5.2e-168 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] 642922228 XM_008194849.1 161 9.66499e-76 PREDICTED: Tribolium castaneum thiamine transporter 2-like (LOC661148), mRNA K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 Q22931 693 7.9e-71 Folate-like transporter 3 OS=Caenorhabditis elegans GN=folt-3 PE=3 SV=3 PF01770//PF00639//PF13145//PF01384 Reduced folate carrier//PPIC-type PPIASE domain//PPIC-type PPIASE domain//Phosphate transporter family GO:0006817//GO:0006810 phosphate ion transport//transport GO:0008518//GO:0016853//GO:0005542//GO:0005315 reduced folate carrier activity//isomerase activity//folic acid binding//inorganic phosphate transmembrane transporter activity GO:0016020 membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.31678 BF_2 794.00 18.93 2042 642925653 XP_008194657.1 238 3.3e-17 PREDICTED: uncharacterized protein LOC662907 [Tribolium castaneum]>gi|270008896|gb|EFA05344.1| hypothetical protein TcasGA2_TC015508 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31681 BF_2 974.00 15.46 2923 332376234 AEE63257.1 1256 4.3e-135 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02867 RP-L11, MRPL11, rplK large subunit ribosomal protein L11 http://www.genome.jp/dbget-bin/www_bget?ko:K02867 Q9VFJ2 460 3.6e-44 39S ribosomal protein L11, mitochondrial OS=Drosophila melanogaster GN=mRpL11 PE=1 SV=1 PF00298//PF01064//PF00106 Ribosomal protein L11, RNA binding domain//Activin types I and II receptor domain//short chain dehydrogenase GO:0006412//GO:0016310//GO:0009069//GO:0008152//GO:0007178//GO:0042254 translation//phosphorylation//serine family amino acid metabolic process//metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway//ribosome biogenesis GO:0016491//GO:0004675//GO:0003735 oxidoreductase activity//transmembrane receptor protein serine/threonine kinase activity//structural constituent of ribosome GO:0016020//GO:0005840 membrane//ribosome KOG3257 Mitochondrial/chloroplast ribosomal protein L11 Cluster-8309.31682 BF_2 107.00 54.68 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31683 BF_2 43.68 0.43 4519 642932410 XP_008197100.1 2437 7.6e-272 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AK53 362 1.3e-32 Espin OS=Homo sapiens GN=ESPN PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31684 BF_2 1120.40 17.92 2902 642923207 XP_969908.2 1738 5.5e-191 PREDICTED: dnaJ homolog subfamily C member 7 [Tribolium castaneum] -- -- -- -- -- K09527 DNAJC7 DnaJ homolog subfamily C member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09527 Q99615 1231 1.4e-133 DnaJ homolog subfamily C member 7 OS=Homo sapiens GN=DNAJC7 PE=1 SV=2 PF13174//PF13181//PF14863//PF06061//PF04196//PF13176//PF13414//PF13374//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Alkyl sulfatase dimerisation//Baculoviridae ME53//Bunyavirus RNA dependent RNA polymerase//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019079//GO:0006351//GO:0006144 viral genome replication//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0046983//GO:0005515//GO:0008270//GO:0003968 DNA binding//protein dimerization activity//protein binding//zinc ion binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG0550 Molecular chaperone (DnaJ superfamily) Cluster-8309.31685 BF_2 21.00 3.90 512 167444206 ABZ80664.1 379 3.7e-34 c-type lysozyme [Sitophilus zeamais] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 P12067 290 3.2e-25 Lysozyme C-1 OS=Sus scrofa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31688 BF_2 435.99 39.40 750 332374164 AEE62223.1 605 3.4e-60 unknown [Dendroctonus ponderosae] 821464696 XM_003759701.2 149 4.87098e-70 PREDICTED: Sarcophilus harrisii transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1), transcript variant X2, mRNA K03872 TCEB1 transcription elongation factor B, polypeptide 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03872 Q2KII4 552 2.0e-55 Transcription elongation factor B polypeptide 1 OS=Bos taurus GN=TCEB1 PE=3 SV=1 PF03931 Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process -- -- -- -- KOG3473 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin C Cluster-8309.31689 BF_2 117.92 0.96 5442 642912602 XP_008200928.1 1127 7.3e-120 PREDICTED: poly(A) RNA polymerase gld-2 homolog A-like [Tribolium castaneum]>gi|270002400|gb|EEZ98847.1| hypothetical protein TcasGA2_TC004457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW4 846 1.2e-88 ER membrane protein complex subunit 3 OS=Danio rerio GN=emc3 PE=2 SV=1 PF01956//PF06596//PF01909 Integral membrane protein DUF106//Photosystem II reaction centre X protein (PsbX)//Nucleotidyltransferase domain GO:0015979 photosynthesis GO:0016779 nucleotidyltransferase activity GO:0009523//GO:0016020 photosystem II//membrane KOG3188 Uncharacterized conserved protein Cluster-8309.31691 BF_2 2.00 0.79 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31692 BF_2 283.77 5.13 2601 478260742 ENN80421.1 1508 2.3e-164 hypothetical protein YQE_03169, partial [Dendroctonus ponderosae] 751463391 XM_011188291.1 154 2.89961e-72 PREDICTED: Bactrocera cucurbitae DNA-directed RNA polymerase II subunit RPB9 (LOC105214718), mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 744 3.7e-77 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF01396//PF10508//PF01096//PF01667//PF06371//PF02150//PF06367//PF00130 Topoisomerase DNA binding C4 zinc finger//Proteasome non-ATPase 26S subunit//Transcription factor S-II (TFIIS)//Ribosomal protein S27//Diaphanous GTPase-binding Domain//RNA polymerases M/15 Kd subunit//Diaphanous FH3 Domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006144//GO:0016043//GO:0006412//GO:0006351//GO:0006206//GO:0035556//GO:0042254//GO:0006265//GO:0030036//GO:0043248 purine nucleobase metabolic process//cellular component organization//translation//transcription, DNA-templated//pyrimidine nucleobase metabolic process//intracellular signal transduction//ribosome biogenesis//DNA topological change//actin cytoskeleton organization//proteasome assembly GO:0003916//GO:0003677//GO:0017048//GO:0003676//GO:0003779//GO:0003899//GO:0003735//GO:0008270 DNA topoisomerase activity//DNA binding//Rho GTPase binding//nucleic acid binding//actin binding//DNA-directed RNA polymerase activity//structural constituent of ribosome//zinc ion binding GO:0005694//GO:0005730//GO:0005840//GO:0005622 chromosome//nucleolus//ribosome//intracellular KOG2691 RNA polymerase II subunit 9 Cluster-8309.31693 BF_2 85.38 0.69 5457 665804096 XP_008550173.1 2041 7.6e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 189008483 EU616810.1 323 6.92538e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 4.0e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF00520//PF00060//PF02214//PF13374 Ion transport protein//Ligand-gated ion channel//BTB/POZ domain//Tetratricopeptide repeat GO:0006811//GO:0007165//GO:0055085//GO:0051260//GO:0007268 ion transport//signal transduction//transmembrane transport//protein homooligomerization//synaptic transmission GO:0005216//GO:0005515//GO:0004970 ion channel activity//protein binding//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.31694 BF_2 1829.71 11.44 6979 91091256 XP_968850.1 1918 1.8e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.6e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF04117//PF00180//PF01398 Mpv17 / PMP22 family//Isocitrate/isopropylmalate dehydrogenase//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006099//GO:0055114//GO:0006102//GO:0006749//GO:0019643 tricarboxylic acid cycle//oxidation-reduction process//isocitrate metabolic process//glutathione metabolic process//reductive tricarboxylic acid cycle GO:0000287//GO:0004450//GO:0016616//GO:0051287//GO:0005515 magnesium ion binding//isocitrate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//protein binding GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.31699 BF_2 2.00 0.63 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.317 BF_2 2.00 0.60 427 270017192 EFA13638.1 209 1.6e-14 hypothetical protein TcasGA2_TC005207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3170 BF_2 5.91 2.86 371 270003038 EEZ99485.1 382 1.2e-34 hypothetical protein TcasGA2_TC000060 [Tribolium castaneum] -- -- -- -- -- K00791 miaA, TRIT1 tRNA dimethylallyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00791 Q9H3H1 274 1.7e-23 tRNA dimethylallyltransferase, mitochondrial OS=Homo sapiens GN=TRIT1 PE=1 SV=1 PF01715 IPP transferase GO:0008033 tRNA processing -- -- -- -- KOG1384 tRNA delta(2)-isopentenylpyrophosphate transferase Cluster-8309.31702 BF_2 504.55 34.95 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31704 BF_2 367.00 19.22 1086 91086169 XP_970456.1 653 1.3e-65 PREDICTED: nucleolysin TIAR [Tribolium castaneum]>gi|270010230|gb|EFA06678.1| hypothetical protein TcasGA2_TC009608 [Tribolium castaneum] 759044574 XM_011332906.1 67 2.74327e-24 PREDICTED: Cerapachys biroi nucleolysin TIAR (LOC105275801), mRNA K13201 TIA1, TIAL1 nucleolysin TIA-1/TIAR http://www.genome.jp/dbget-bin/www_bget?ko:K13201 P31483 418 9.8e-40 Nucleolysin TIA-1 isoform p40 OS=Homo sapiens GN=TIA1 PE=1 SV=3 PF04995//PF08777//PF00076 Heme exporter protein D (CcmD)//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0017004//GO:0015886 cytochrome complex assembly//heme transport GO:0003723//GO:0000166//GO:0003676 RNA binding//nucleotide binding//nucleic acid binding GO:0016021 integral component of membrane KOG0148 Apoptosis-promoting RNA-binding protein TIA-1/TIAR (RRM superfamily) Cluster-8309.31705 BF_2 4620.47 58.59 3586 577754854 AHH86056.1 1979 7.8e-219 glycoside hydrolase family 31 [Phaedon cochleariae] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 875 3.3e-92 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055//PF01607 Glycosyl hydrolases family 31//Chitin binding Peritrophin-A domain GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding GO:0005576 extracellular region KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.31707 BF_2 3.00 0.45 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31708 BF_2 125.52 0.88 6239 189242464 XP_968866.2 873 2.4e-90 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|642939237|ref|XP_008194772.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|642939239|ref|XP_008194773.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|270016396|gb|EFA12842.1| hypothetical protein TcasGA2_TC006942 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7TSX5 552 1.6e-54 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Rattus norvegicus GN=Sgms1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.31709 BF_2 1292.98 9.17 6183 189242464 XP_968866.2 1250 4.6e-134 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|642939237|ref|XP_008194772.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|642939239|ref|XP_008194773.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X2 [Tribolium castaneum]>gi|270016396|gb|EFA12842.1| hypothetical protein TcasGA2_TC006942 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7T3T4 694 5.6e-71 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Gallus gallus GN=SGMS1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.31710 BF_2 246.60 2.49 4429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31712 BF_2 46.65 0.86 2545 642927489 XP_008195288.1 1569 1.9e-171 PREDICTED: neuropilin and tolloid-like protein 1 [Tribolium castaneum] 642927488 XM_008197066.1 249 4.39084e-125 PREDICTED: Tribolium castaneum neuropilin and tolloid-like protein 1 (LOC658952), mRNA -- -- -- -- Q8NC67 400 2.8e-37 Neuropilin and tolloid-like protein 2 OS=Homo sapiens GN=NETO2 PE=1 SV=1 PF02535//PF00057//PF00430//PF01956 ZIP Zinc transporter//Low-density lipoprotein receptor domain class A//ATP synthase B/B' CF(0)//Integral membrane protein DUF106 GO:0055085//GO:0030001//GO:0015992//GO:0015986 transmembrane transport//metal ion transport//proton transport//ATP synthesis coupled proton transport GO:0005515//GO:0046873//GO:0015078 protein binding//metal ion transmembrane transporter activity//hydrogen ion transmembrane transporter activity GO:0016020//GO:0045263 membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.31716 BF_2 129.02 2.96 2110 642915291 XP_008190557.1 1179 2.7e-126 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 605 4.0e-61 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.31717 BF_2 19832.00 911.83 1197 578359016 AHI15751.1 1717 6.2e-189 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359015 KJ186853.1 1076 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-6) mRNA, complete cds -- -- -- -- P07103 637 4.4e-65 Endoglucanase Z OS=Dickeya dadantii (strain 3937) GN=celZ PE=1 SV=2 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.31718 BF_2 23.47 0.40 2712 728416984 AIY68330.1 1206 2.5e-129 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 580 4.0e-58 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.31719 BF_2 92.41 3.39 1428 478254827 ENN75063.1 680 1.3e-68 hypothetical protein YQE_08376, partial [Dendroctonus ponderosae] -- -- -- -- -- K15700 RNF146 E3 ubiquitin-protein ligase RNF146 http://www.genome.jp/dbget-bin/www_bget?ko:K15700 Q2PFU6 451 1.9e-43 E3 ubiquitin-protein ligase RNF146 OS=Macaca fascicularis GN=RNF146 PE=2 SV=1 PF14634//PF12678//PF00097//PF16685//PF13639 zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//zinc RING finger of MSL2//Ring finger domain -- -- GO:0061630//GO:0046872//GO:0005515//GO:0008270 ubiquitin protein ligase activity//metal ion binding//protein binding//zinc ion binding -- -- KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein Cluster-8309.31722 BF_2 887.46 8.40 4705 91084835 XP_966560.1 1369 5.5e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 6.7e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00892//PF13895//PF00114//PF06027//PF08449//PF04142//PF00893 EamA-like transporter family//Immunoglobulin domain//Pilin (bacterial filament)//Solute carrier family 35//UAA transporter family//Nucleotide-sugar transporter//Small Multidrug Resistance protein GO:0055085//GO:0006810//GO:0007155//GO:0008643 transmembrane transport//transport//cell adhesion//carbohydrate transport GO:0005351//GO:0005515 sugar:proton symporter activity//protein binding GO:0016021//GO:0009289//GO:0016020//GO:0000139 integral component of membrane//pilus//membrane//Golgi membrane KOG3912 Predicted integral membrane protein Cluster-8309.31724 BF_2 49.52 1.12 2137 91076522 XP_973518.1 1440 1.5e-156 PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|642912580|ref|XP_008200918.1| PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|270002610|gb|EEZ99057.1| hypothetical protein TcasGA2_TC004932 [Tribolium castaneum] 669193686 KF516645.1 38 7.24036e-08 Paracyclopina nana programmed cell death protein 4 mRNA, partial cds K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 606 3.1e-61 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.31725 BF_2 3456.93 98.05 1762 91076522 XP_973518.1 1440 1.2e-156 PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|642912580|ref|XP_008200918.1| PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|270002610|gb|EEZ99057.1| hypothetical protein TcasGA2_TC004932 [Tribolium castaneum] 669193686 KF516645.1 38 5.94867e-08 Paracyclopina nana programmed cell death protein 4 mRNA, partial cds K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 606 2.5e-61 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.31728 BF_2 321.00 12.74 1341 156547143 XP_001603315.1 923 8.2e-97 PREDICTED: etoposide-induced protein 2.4 homolog [Nasonia vitripennis] -- -- -- -- -- K10134 EI24 etoposide-induced 2.4 mRNA http://www.genome.jp/dbget-bin/www_bget?ko:K10134 Q08DE5 659 1.4e-67 Etoposide-induced protein 2.4 homolog OS=Bos taurus GN=EI24 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3966 p53-mediated apoptosis protein EI24/PIG8 Cluster-8309.31729 BF_2 306.28 13.57 1231 91078580 XP_971846.1 727 4.0e-74 PREDICTED: UDP-N-acetylglucosamine transferase subunit ALG14 homolog [Tribolium castaneum]>gi|270004042|gb|EFA00490.1| hypothetical protein TcasGA2_TC003350 [Tribolium castaneum] -- -- -- -- -- K07441 ALG14 beta-1,4-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07441 Q9D081 457 3.3e-44 UDP-N-acetylglucosamine transferase subunit ALG14 homolog OS=Mus musculus GN=Alg14 PE=2 SV=1 PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0000775//GO:0005634 chromosome, centromeric region//nucleus KOG3339 Predicted glycosyltransferase Cluster-8309.3173 BF_2 25.00 0.58 2097 642928198 XP_008195486.1 1277 1.1e-137 PREDICTED: thyrotropin receptor-like [Tribolium castaneum] -- -- -- -- -- K04248 LHCGR luteinizing hormone/choriogonadotropin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04248 P30730 915 4.5e-97 Lutropin-choriogonadotropic hormone receptor OS=Mus musculus GN=Lhcgr PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG2087 Glycoprotein hormone receptor Cluster-8309.31732 BF_2 45.52 0.73 2910 91078706 XP_971901.1 1904 3.1e-210 PREDICTED: putative RNA exonuclease NEF-sp [Tribolium castaneum]>gi|270003754|gb|EFA00202.1| hypothetical protein TcasGA2_TC003027 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q4R9F7 466 7.2e-45 Putative RNA exonuclease NEF-sp OS=Macaca fascicularis GN=QtsA-10054 PE=2 SV=1 -- -- -- -- GO:0003676//GO:0004527 nucleic acid binding//exonuclease activity GO:0005622 intracellular KOG2248 3'-5' exonuclease Cluster-8309.31733 BF_2 397.30 6.19 2970 91078706 XP_971901.1 1958 1.7e-216 PREDICTED: putative RNA exonuclease NEF-sp [Tribolium castaneum]>gi|270003754|gb|EFA00202.1| hypothetical protein TcasGA2_TC003027 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q4R9F7 466 7.3e-45 Putative RNA exonuclease NEF-sp OS=Macaca fascicularis GN=QtsA-10054 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2248 3'-5' exonuclease Cluster-8309.31735 BF_2 356.06 7.44 2290 642920207 XP_008192249.1 940 1.5e-98 PREDICTED: plancitoxin-1 [Tribolium castaneum] -- -- -- -- -- K01158 DNASE2 deoxyribonuclease II http://www.genome.jp/dbget-bin/www_bget?ko:K01158 Q75WF2 570 4.9e-57 Plancitoxin-1 OS=Acanthaster planci PE=1 SV=1 PF03265//PF15880 Deoxyribonuclease II//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial GO:0006308//GO:0006259 DNA catabolic process//DNA metabolic process GO:0004531 deoxyribonuclease II activity GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG3825 Deoxyribonuclease II Cluster-8309.31736 BF_2 370.88 2.39 6789 642929749 XP_008195960.1 2170 1.0e-240 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.32427e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05887//PF05433//PF03067//PF09172 Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain//Chitin binding domain//Domain of unknown function (DUF1943) GO:0006869 lipid transport GO:0005319 lipid transporter activity GO:0016020//GO:0019867//GO:0019028 membrane//outer membrane//viral capsid -- -- Cluster-8309.31737 BF_2 683.83 9.26 3378 91078826 XP_971080.1 2362 2.8e-263 PREDICTED: endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase [Tribolium castaneum]>gi|270003721|gb|EFA00169.1| hypothetical protein TcasGA2_TC002991 [Tribolium castaneum] 347970839 XM_308110.5 56 1.13463e-17 Anopheles gambiae str. PEST AGAP003884-PA (AgaP_AGAP003884) mRNA, complete cds K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 Q9UKM7 1389 7.8e-152 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase OS=Homo sapiens GN=MAN1B1 PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2431 1, 2-alpha-mannosidase Cluster-8309.31740 BF_2 87.10 1.13 3516 189240719 XP_974316.2 757 3.8e-77 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z1A9 220 2.9e-16 TBC1 domain family member 8 OS=Mus musculus GN=Tbc1d8 PE=2 SV=2 PF01213//PF10637 Adenylate cyclase associated (CAP) N terminal//Oxoglutarate and iron-dependent oxygenase degradation C-term GO:0055114//GO:0007010 oxidation-reduction process//cytoskeleton organization GO:0005506//GO:0003779//GO:0031418//GO:0016706 iron ion binding//actin binding//L-ascorbic acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.31744 BF_2 66.65 3.10 1186 270004586 EFA01034.1 632 4.0e-63 hypothetical protein TcasGA2_TC003950 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q4V348 548 9.1e-55 Zinc finger protein 658B OS=Homo sapiens GN=ZNF658B PE=2 SV=1 PF02892//PF13912//PF16622//PF00096//PF13465 BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.31745 BF_2 2208.58 14.74 6553 642914575 XP_971897.2 4166 0.0e+00 PREDICTED: insulin-degrading enzyme [Tribolium castaneum] -- -- -- -- -- K01408 IDE, ide insulysin http://www.genome.jp/dbget-bin/www_bget?ko:K01408 Q24K02 2825 0.0e+00 Insulin-degrading enzyme OS=Bos taurus GN=IDE PE=2 SV=1 PF14560 Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.31746 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31747 BF_2 341.99 16.24 1168 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3175 BF_2 10.00 0.37 1422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31750 BF_2 2130.32 82.91 1362 91079082 XP_975256.1 821 5.6e-85 PREDICTED: translocon-associated protein subunit alpha [Tribolium castaneum]>gi|270004205|gb|EFA00653.1| hypothetical protein TcasGA2_TC003529 [Tribolium castaneum] -- -- -- -- -- K13249 SSR1 translocon-associated protein subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13249 Q9CY50 444 1.2e-42 Translocon-associated protein subunit alpha OS=Mus musculus GN=Ssr1 PE=1 SV=1 PF03896 Translocon-associated protein (TRAP), alpha subunit -- -- -- -- GO:0005783//GO:0005789 endoplasmic reticulum//endoplasmic reticulum membrane KOG1631 Translocon-associated complex TRAP, alpha subunit Cluster-8309.31751 BF_2 135.38 4.45 1561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.31752 BF_2 84.94 0.99 3872 189240740 XP_968238.2 2467 2.2e-275 PREDICTED: phospholipase A-2-activating protein [Tribolium castaneum] -- -- -- -- -- K14018 PLAA, DOA1, UFD3 phospholipase A-2-activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K14018 Q9Y263 1082 3.5e-116 Phospholipase A-2-activating protein OS=Homo sapiens GN=PLAA PE=1 SV=2 PF00400//PF05676 WD domain, G-beta repeat//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0006120//GO:0015992//GO:0006744//GO:0006814//GO:0006118 mitochondrial electron transport, NADH to ubiquinone//proton transport//ubiquinone biosynthetic process//sodium ion transport//obsolete electron transport GO:0003954//GO:0005515//GO:0008137 NADH dehydrogenase activity//protein binding//NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion KOG0301 Phospholipase A2-activating protein (contains WD40 repeats) Cluster-8309.31755 BF_2 472.35 13.07 1799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31756 BF_2 63.33 1.31 2315 752899225 XP_011267995.1 654 2.2e-65 PREDICTED: coatomer subunit zeta-1 [Camponotus floridanus] 346709586 AK384066.1 60 4.62732e-20 Bombyx mori mRNA, clone: fcaL06G10 K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 536 4.4e-53 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG3343 Vesicle coat complex COPI, zeta subunit Cluster-8309.31757 BF_2 140.57 2.97 2266 270009732 EFA06180.1 698 1.7e-70 hypothetical protein TcasGA2_TC009027 [Tribolium castaneum] 346709586 AK384066.1 60 4.52787e-20 Bombyx mori mRNA, clone: fcaL06G10 K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 536 4.3e-53 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG3343 Vesicle coat complex COPI, zeta subunit Cluster-8309.31759 BF_2 81.14 0.41 8524 478256345 ENN76535.1 247 1.3e-17 hypothetical protein YQE_06986, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05859//PF07464//PF04623//PF01442 Mis12 protein//Apolipophorin-III precursor (apoLp-III)//Adenovirus E1B protein N-terminus//Apolipoprotein A1/A4/E domain GO:0007067//GO:0007049//GO:0009605//GO:0042157//GO:0006869 mitotic nuclear division//cell cycle//response to external stimulus//lipoprotein metabolic process//lipid transport GO:0008289 lipid binding GO:0000775//GO:0005576//GO:0005634 chromosome, centromeric region//extracellular region//nucleus -- -- Cluster-8309.31761 BF_2 695.75 4.81 6335 642921944 XP_008192953.1 8292 0.0e+00 PREDICTED: dedicator of cytokinesis protein 7 [Tribolium castaneum] 769853772 XM_011640095.1 123 1.21568e-54 PREDICTED: Pogonomyrmex barbatus dedicator of cytokinesis protein 7 (LOC105428043), mRNA -- -- -- -- Q96N67 4645 0.0e+00 Dedicator of cytokinesis protein 7 OS=Homo sapiens GN=DOCK7 PE=1 SV=4 PF05412 Equine arterivirus Nsp2-type cysteine proteinase GO:0019082//GO:0016032 viral protein processing//viral process -- -- -- -- KOG1997 PH domain-containing protein Cluster-8309.31762 BF_2 597.14 7.22 3746 91089675 XP_974428.1 1381 1.8e-149 PREDICTED: probable trans-2-enoyl-CoA reductase, mitochondrial [Tribolium castaneum]>gi|270012629|gb|EFA09077.1| hypothetical protein TcasGA2_TC006794 [Tribolium castaneum] -- -- -- -- -- K07512 MECR, NRBF1 mitochondrial trans-2-enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07512 Q9V6U9 1031 2.8e-110 Probable trans-2-enoyl-CoA reductase, mitochondrial OS=Drosophila melanogaster GN=CG16935 PE=3 SV=2 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0000166//GO:0008270//GO:0016491 nucleotide binding//zinc ion binding//oxidoreductase activity -- -- KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) Cluster-8309.31765 BF_2 312.07 1.98 6885 549438529 AGX25153.1 1932 4.2e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- O61491 815 5.8e-85 Flotillin-1 OS=Drosophila melanogaster GN=Flo-1 PE=2 SV=1 PF01743//PF00085//PF04777 Poly A polymerase head domain//Thioredoxin//Erv1 / Alr family GO:0045454//GO:0055114//GO:0006396 cell redox homeostasis//oxidation-reduction process//RNA processing GO:0016779//GO:0016972//GO:0003723 nucleotidyltransferase activity//thiol oxidase activity//RNA binding -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.31767 BF_2 1998.14 16.52 5348 549438529 AGX25153.1 1932 3.3e-213 sulfhydryl oxidase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61491 1566 3.7e-172 Flotillin-1 OS=Drosophila melanogaster GN=Flo-1 PE=2 SV=1 PF01743//PF04777//PF00085 Poly A polymerase head domain//Erv1 / Alr family//Thioredoxin GO:0006396//GO:0045454//GO:0055114 RNA processing//cell redox homeostasis//oxidation-reduction process GO:0016972//GO:0016779//GO:0003723 thiol oxidase activity//nucleotidyltransferase activity//RNA binding -- -- KOG1731 FAD-dependent sulfhydryl oxidase/quiescin and related proteins Cluster-8309.31769 BF_2 181.89 5.03 1799 91093509 XP_969295.1 1113 1.0e-118 PREDICTED: ras-related protein Rab-39B [Tribolium castaneum]>gi|270002676|gb|EEZ99123.1| hypothetical protein TcasGA2_TC005229 [Tribolium castaneum] -- -- -- -- -- K07925 RAB39B Ras-related protein Rab-39B http://www.genome.jp/dbget-bin/www_bget?ko:K07925 Q8BHD0 613 4.0e-62 Ras-related protein Rab-39A OS=Mus musculus GN=Rab39a PE=1 SV=1 PF08477//PF03193//PF01926//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0015031//GO:0007264 protein transport//small GTPase mediated signal transduction GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.31771 BF_2 137.01 4.72 1502 478254830 ENN75066.1 466 9.0e-44 hypothetical protein YQE_08379, partial [Dendroctonus ponderosae] -- -- -- -- -- K16833 PPP1R2, IPP2 protein phosphatase inhibitor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16833 P11845 230 8.6e-18 Protein phosphatase inhibitor 2 OS=Oryctolagus cuniculus GN=PPP1R2 PE=1 SV=3 PF04979//PF04272 Protein phosphatase inhibitor 2 (IPP-2)//Phospholamban GO:0043666//GO:0006816//GO:0009966//GO:0006810 regulation of phosphoprotein phosphatase activity//calcium ion transport//regulation of signal transduction//transport GO:0005246//GO:0004864//GO:0042030 calcium channel regulator activity//protein phosphatase inhibitor activity//ATPase inhibitor activity GO:0016020 membrane KOG4041 Protein phosphatase 1, regulatory (inhibitor) subunit PPP1R2 Cluster-8309.31772 BF_2 60.32 2.02 1534 642918287 XP_008191445.1 486 4.4e-46 PREDICTED: uncharacterized protein LOC655985 isoform X1 [Tribolium castaneum]>gi|270003276|gb|EEZ99723.1| hypothetical protein TcasGA2_TC002488 [Tribolium castaneum] -- -- -- -- -- K07127 uraH, pucM, hiuH 5-hydroxyisourate hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07127 Q9CRB3 246 1.2e-19 5-hydroxyisourate hydrolase OS=Mus musculus GN=Urah PE=1 SV=1 PF01060 Transthyretin-like family GO:0006144//GO:0006810 purine nucleobase metabolic process//transport GO:0033971 hydroxyisourate hydrolase activity GO:0005615 extracellular space KOG3006 Transthyretin and related proteins Cluster-8309.31774 BF_2 819.54 25.70 1621 546683249 ERL93081.1 583 2.6e-57 hypothetical protein D910_10383 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q71RG4 208 3.3e-15 Transmembrane and ubiquitin-like domain-containing protein 2 OS=Homo sapiens GN=TMUB2 PE=1 SV=2 PF00240//PF00032 Ubiquitin family//Cytochrome b(C-terminal)/b6/petD GO:0006118 obsolete electron transport GO:0005515//GO:0016491//GO:0009055 protein binding//oxidoreductase activity//electron carrier activity GO:0016020 membrane -- -- Cluster-8309.31775 BF_2 23.00 4.08 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31777 BF_2 398.27 12.22 1650 642922919 XP_008200452.1 634 3.3e-63 PREDICTED: uncharacterized protein LOC103314926 [Tribolium castaneum] -- -- -- -- -- K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9BX70 222 8.0e-17 BTB/POZ domain-containing protein 2 OS=Homo sapiens GN=BTBD2 PE=1 SV=1 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.3178 BF_2 27.00 0.57 2270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31780 BF_2 767.00 97.27 617 -- -- -- -- -- 820857101 XM_003696473.2 71 9.08518e-27 PREDICTED: Apis florea 26S proteasome complex subunit DSS1 (LOC100863585), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31782 BF_2 289.67 21.19 859 642915202 XP_008190517.1 420 1.1e-38 PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum]>gi|642915204|ref|XP_008190519.1| PREDICTED: gelsolin-related protein of 125 kDa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31783 BF_2 162.55 2.95 2590 642915200 XP_008190516.1 1322 8.5e-143 PREDICTED: myb-like protein X isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULV3 169 1.8e-10 Cip1-interacting zinc finger protein OS=Homo sapiens GN=CIZ1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31784 BF_2 39.00 8.45 480 197927108 NP_001128195.1 164 3.0e-09 dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 [Tribolium castaneum]>gi|642929132|ref|XP_008195704.1| PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3MFK1 124 5.4e-06 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4 OS=Drosophila ananassae GN=GF13081 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31786 BF_2 673.94 8.52 3598 91085981 XP_971976.1 3595 0.0e+00 PREDICTED: cullin-1 [Tribolium castaneum]>gi|642927556|ref|XP_008195314.1| PREDICTED: cullin-1 [Tribolium castaneum] -- -- -- -- -- K03347 CUL1, CDC53 cullin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03347 Q9WTX6 3029 0.0e+00 Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 PF00888//PF03965 Cullin family//Penicillinase repressor GO:0045892//GO:0006511 negative regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0003677 ubiquitin protein ligase binding//DNA binding -- -- KOG2166 Cullins Cluster-8309.31787 BF_2 15.00 0.55 1424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31788 BF_2 5.61 0.93 540 385199976 AFI45036.1 161 7.5e-09 cytochrome P450 CYP6DG1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.31790 BF_2 63.12 0.80 3603 189237709 XP_001810287.1 1203 7.5e-129 PREDICTED: protein brambleberry-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I6V1W0 541 1.8e-53 Protein brambleberry OS=Danio rerio GN=bmb PE=2 SV=1 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.31791 BF_2 154.88 1.78 3935 642924296 XP_008194236.1 1397 2.6e-151 PREDICTED: protein brambleberry-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I6V1W0 604 9.6e-61 Protein brambleberry OS=Danio rerio GN=bmb PE=2 SV=1 PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.31792 BF_2 46.28 1.11 2032 270014557 EFA11005.1 293 1.4e-23 hypothetical protein TcasGA2_TC004590 [Tribolium castaneum] 642911747 XM_008202503.1 179 2.85784e-86 PREDICTED: Tribolium castaneum 14-3-3 protein zeta (LOC660150), mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 260 3.9e-21 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.31795 BF_2 723.70 22.05 1660 642937984 XP_008199157.1 397 1.0e-35 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5PK40 281 1.2e-23 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.31796 BF_2 1519.96 19.39 3567 91089279 XP_970539.1 2343 4.8e-261 PREDICTED: serine/threonine-protein kinase unc-51 isoform X1 [Tribolium castaneum]>gi|270011454|gb|EFA07902.1| hypothetical protein TcasGA2_TC005477 [Tribolium castaneum] 820865549 XM_003698790.2 61 1.99186e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 967 7.1e-103 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF07714//PF12063//PF06293//PF00069 Protein tyrosine kinase//Domain of unknown function (DUF3543)//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0000166//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//nucleotide binding//ATP binding GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.31798 BF_2 1265.17 11.47 4903 189236467 XP_974325.2 3327 0.0e+00 PREDICTED: protein transport protein Sec24A [Tribolium castaneum]>gi|642919906|ref|XP_008192119.1| PREDICTED: protein transport protein Sec24A [Tribolium castaneum]>gi|270005372|gb|EFA01820.1| hypothetical protein TcasGA2_TC007422 [Tribolium castaneum] -- -- -- -- -- K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 O95487 2150 6.5e-240 Protein transport protein Sec24B OS=Homo sapiens GN=SEC24B PE=1 SV=2 PF04811//PF04810//PF04815 Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1985 Vesicle coat complex COPII, subunit SEC24/subunit SFB2 Cluster-8309.31799 BF_2 279.83 2.29 5403 189236467 XP_974325.2 3328 0.0e+00 PREDICTED: protein transport protein Sec24A [Tribolium castaneum]>gi|642919906|ref|XP_008192119.1| PREDICTED: protein transport protein Sec24A [Tribolium castaneum]>gi|270005372|gb|EFA01820.1| hypothetical protein TcasGA2_TC007422 [Tribolium castaneum] -- -- -- -- -- K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 O95487 2151 5.5e-240 Protein transport protein Sec24B OS=Homo sapiens GN=SEC24B PE=1 SV=2 PF04815//PF04811//PF04810 Sec23/Sec24 helical domain//Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1985 Vesicle coat complex COPII, subunit SEC24/subunit SFB2 Cluster-8309.31800 BF_2 1766.11 20.92 3818 189240740 XP_968238.2 2495 1.2e-278 PREDICTED: phospholipase A-2-activating protein [Tribolium castaneum] -- -- -- -- -- K14018 PLAA, DOA1, UFD3 phospholipase A-2-activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K14018 Q9Y263 1106 5.8e-119 Phospholipase A-2-activating protein OS=Homo sapiens GN=PLAA PE=1 SV=2 PF05676//PF00400 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//WD domain, G-beta repeat GO:0006120//GO:0006744//GO:0006814//GO:0006118//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//obsolete electron transport//proton transport GO:0003954//GO:0005515//GO:0008137 NADH dehydrogenase activity//protein binding//NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion KOG0301 Phospholipase A2-activating protein (contains WD40 repeats) Cluster-8309.31804 BF_2 190.92 5.83 1656 340711564 XP_003394345.1 1024 2.0e-108 PREDICTED: zinc finger CCCH-type with G patch domain-containing protein [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q17CQ8 998 8.3e-107 Zinc finger CCCH-type with G patch domain-containing protein OS=Aedes aegypti GN=AAEL004458 PE=3 SV=1 PF01585//PF00642 G-patch domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0003676//GO:0046872 nucleic acid binding//metal ion binding -- -- KOG2185 Predicted RNA-processing protein, contains G-patch domain Cluster-8309.31805 BF_2 92.47 2.85 1644 270014745 EFA11193.1 194 3.4e-12 hypothetical protein TcasGA2_TC004801 [Tribolium castaneum] -- -- -- -- -- K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I1A6 171 6.5e-11 Endophilin-A OS=Drosophila willistoni GN=endoA PE=3 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.31806 BF_2 192.98 1.93 4470 189234578 XP_974655.2 1464 5.0e-159 PREDICTED: glucosidase 2 subunit beta [Tribolium castaneum] 760445822 XM_011401678.1 38 1.52682e-07 Auxenochlorella protothecoides Protein disulfide-isomerase 1 partial mRNA K08288 PRKCSH protein kinase C substrate 80K-H http://www.genome.jp/dbget-bin/www_bget?ko:K08288 O08795 931 1.3e-98 Glucosidase 2 subunit beta OS=Mus musculus GN=Prkcsh PE=1 SV=1 PF13499//PF04147//PF13833//PF13405//PF00057//PF04111//PF00085//PF03015//PF00036//PF13202 EF-hand domain pair//Nop14-like family//EF-hand domain pair//EF-hand domain//Low-density lipoprotein receptor domain class A//Autophagy protein Apg6//Thioredoxin//Male sterility protein//EF hand//EF hand GO:0045454//GO:0006914 cell redox homeostasis//autophagy GO:0005515//GO:0080019//GO:0005509 protein binding//fatty-acyl-CoA reductase (alcohol-forming) activity//calcium ion binding GO:0032040 small-subunit processome KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.31809 BF_2 34.44 0.56 2869 332372580 AEE61432.1 600 5.0e-59 unknown [Dendroctonus ponderosae]>gi|478260722|gb|ENN80403.1| hypothetical protein YQE_03175, partial [Dendroctonus ponderosae] -- -- -- -- -- K00825 AADAT, KAT2 kynurenine/2-aminoadipate aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00825 Q8N5Z0 303 5.6e-26 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial OS=Homo sapiens GN=AADAT PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0634 Aromatic amino acid aminotransferase and related proteins Cluster-8309.31811 BF_2 5334.73 82.11 3005 91081871 XP_968443.1 3058 0.0e+00 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q9UL12 1899 5.0e-211 Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1 PF12831//PF01134//PF01266//PF07992//PF11501//PF13241//PF01494 FAD dependent oxidoreductase//Glucose inhibited division protein A//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Non structural protein Nsp1//Putative NAD(P)-binding//FAD binding domain GO:0044710//GO:0019354//GO:0006508//GO:0008033//GO:0006779//GO:0055114 single-organism metabolic process//siroheme biosynthetic process//proteolysis//tRNA processing//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0016491//GO:0043115//GO:0008242//GO:0003824//GO:0016788//GO:0016817//GO:0004197//GO:0050660//GO:0016740//GO:0071949 oxidoreductase activity//precorrin-2 dehydrogenase activity//omega peptidase activity//catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//flavin adenine dinucleotide binding//transferase activity//FAD binding -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.31814 BF_2 636.67 7.01 4084 546676948 ERL87872.1 1823 1.1e-200 hypothetical protein D910_05260 [Dendroctonus ponderosae] -- -- -- -- -- K10416 DYNC1LI, DNCLI dynein light intermediate chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10416 O43237 989 2.3e-105 Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens GN=DYNC1LI2 PE=1 SV=1 PF00005//PF08477//PF02892//PF00503//PF00025//PF10662//PF13465 ABC transporter//Ras of Complex, Roc, domain of DAPkinase//BED zinc finger//G-protein alpha subunit//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//Zinc-finger double domain GO:0007165//GO:0006576//GO:0007186//GO:0007264 signal transduction//cellular biogenic amine metabolic process//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0003677//GO:0031683//GO:0005524//GO:0003924//GO:0016887//GO:0019001//GO:0004871//GO:0005525//GO:0046872 DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//ATPase activity//guanyl nucleotide binding//signal transducer activity//GTP binding//metal ion binding -- -- KOG2482 Predicted C2H2-type Zn-finger protein Cluster-8309.31815 BF_2 228.46 4.84 2261 642940150 XP_008194838.1 698 1.7e-70 PREDICTED: protein SPT2 homolog [Tribolium castaneum]>gi|270016871|gb|EFA13317.1| hypothetical protein TcasGA2_TC006901 [Tribolium castaneum] -- -- -- -- -- K15193 SPTY2D1, SPT2 protein SPT2 http://www.genome.jp/dbget-bin/www_bget?ko:K15193 Q8IMP6 253 2.8e-20 Protein SPT2 homolog OS=Drosophila melanogaster GN=CG5815 PE=1 SV=1 PF13971 Meiosis-specific protein Mei4 GO:0006310//GO:0042138 DNA recombination//meiotic DNA double-strand break formation -- -- -- -- -- -- Cluster-8309.31818 BF_2 333.00 68.95 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31819 BF_2 852.56 56.09 923 189235487 XP_968396.2 1031 1.7e-109 PREDICTED: failed axon connections isoform X1 [Tribolium castaneum] 645031495 XM_008211925.1 220 2.05553e-109 PREDICTED: Nasonia vitripennis failed axon connections (LOC100123191), transcript variant X3, mRNA -- -- -- -- Q95RI5 877 5.0e-93 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF13417 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG4244 Failed axon connections (fax) protein/glutathione S-transferase-like protein Cluster-8309.31820 BF_2 1615.60 19.89 3685 642920513 XP_008192381.1 2781 0.0e+00 PREDICTED: eukaryotic translation initiation factor 5B [Tribolium castaneum] 665796798 XM_008547981.1 498 0 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5B (LOC103570285), mRNA K03243 EIF5B translation initiation factor 5B http://www.genome.jp/dbget-bin/www_bget?ko:K03243 O60841 2249 1.6e-251 Eukaryotic translation initiation factor 5B OS=Homo sapiens GN=EIF5B PE=1 SV=4 PF01926//PF03144//PF08477//PF03376 50S ribosome-binding GTPase//Elongation factor Tu domain 2//Ras of Complex, Roc, domain of DAPkinase//Adenovirus E3B protein GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0016020 membrane KOG1144 Translation initiation factor 5B (eIF-5B) Cluster-8309.31826 BF_2 891.79 12.28 3326 668458814 KFB46677.1 1068 3.1e-113 hypothetical protein ZHAS_00014689 [Anopheles sinensis] -- -- -- -- -- K13577 SLC25A10, DIC solute carrier family 25 (mitochondrial dicarboxylate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13577 Q9UBX3 826 1.5e-86 Mitochondrial dicarboxylate carrier OS=Homo sapiens GN=SLC25A10 PE=1 SV=2 PF10483//PF09807 Elongator subunit Iki1//Elongation complex protein 6 -- -- -- -- GO:0033588 Elongator holoenzyme complex KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.31830 BF_2 1456.23 64.68 1229 291170322 ADD82417.1 552 7.8e-54 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 321 1.97378e-165 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.31832 BF_2 147.72 1.85 3628 91089961 XP_973612.1 1197 3.7e-128 PREDICTED: beta-1,4-galactosyltransferase 7 [Tribolium castaneum]>gi|270013550|gb|EFA09998.1| hypothetical protein TcasGA2_TC012167 [Tribolium castaneum] -- -- -- -- -- K00733 B4GALT7 xylosylprotein 4-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00733 Q8R087 728 3.7e-75 Beta-1,4-galactosyltransferase 7 OS=Mus musculus GN=B4galt7 PE=2 SV=1 -- -- GO:0005975 carbohydrate metabolic process GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.31833 BF_2 1471.46 12.86 5073 546675851 ERL86956.1 2661 9.1e-298 hypothetical protein D910_04359 [Dendroctonus ponderosae] 676491074 XM_009067230.1 96 9.93438e-40 Lottia gigantea hypothetical protein mRNA K12179 COPS6, CSN6 COP9 signalosome complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12179 Q9VCY3 1146 1.8e-123 COP9 signalosome complex subunit 6 OS=Drosophila melanogaster GN=CSN6 PE=1 SV=1 PF05028//PF01398//PF00848 Poly (ADP-ribose) glycohydrolase (PARG)//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Ring hydroxylating alpha subunit (catalytic domain) GO:0019439//GO:0005975//GO:0055114 aromatic compound catabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0051537//GO:0005515//GO:0016708//GO:0005506//GO:0004649 2 iron, 2 sulfur cluster binding//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor//iron ion binding//poly(ADP-ribose) glycohydrolase activity -- -- KOG3050 COP9 signalosome, subunit CSN6 Cluster-8309.31834 BF_2 42.00 1.38 1557 748995290 AJE75667.1 1477 5.5e-161 putative glycosyl hydrolase [Chrysomela lapponica] 634006789 KF377833.1 35 2.43912e-06 Phyllotreta striolata myrosinase mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1192 2.5e-129 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.31836 BF_2 2581.33 65.45 1937 91089983 XP_974005.1 2115 7.1e-235 PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934014|ref|XP_008197604.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|642934016|ref|XP_008197605.1| PREDICTED: phosphoglucomutase-2 [Tribolium castaneum]>gi|270013684|gb|EFA10132.1| hypothetical protein TcasGA2_TC012312 [Tribolium castaneum] -- -- -- -- -- K15779 PGM2 phosphoglucomutase / phosphopentomutase http://www.genome.jp/dbget-bin/www_bget?ko:K15779 Q96G03 1526 5.8e-168 Phosphoglucomutase-2 OS=Homo sapiens GN=PGM2 PE=1 SV=4 PF02878//PF00408//PF02879//PF02880 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III GO:0071704//GO:0005975 organic substance metabolic process//carbohydrate metabolic process GO:0016868//GO:0000287 intramolecular transferase activity, phosphotransferases//magnesium ion binding -- -- KOG1220 Phosphoglucomutase/phosphomannomutase Cluster-8309.31837 BF_2 1417.94 15.34 4154 642913764 XP_008201151.1 5037 0.0e+00 PREDICTED: neuropathy target esterase sws isoform X3 [Tribolium castaneum] -- -- -- -- -- K14676 NTE, NRE lysophospholipid hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14676 B4IL64 3174 0.0e+00 Neuropathy target esterase sws OS=Drosophila sechellia GN=sws PE=3 SV=1 PF12387//PF01734 Pestivirus NS2 peptidase//Patatin-like phospholipase GO:0006508//GO:0006629//GO:0006144 proteolysis//lipid metabolic process//purine nucleobase metabolic process GO:0017111//GO:0004252//GO:0016817//GO:0004197//GO:0070008//GO:0003968 nucleoside-triphosphatase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//serine-type exopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG2968 Predicted esterase of the alpha-beta hydrolase superfamily (Neuropathy target esterase), contains cAMP-binding domains Cluster-8309.31838 BF_2 2.00 1.11 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31840 BF_2 89.20 1.30 3151 642928441 XP_008193786.1 274 3.5e-21 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31842 BF_2 382.11 2.31 7212 642935013 XP_008199906.1 2171 8.5e-241 PREDICTED: helicase ARIP4 isoform X1 [Tribolium castaneum] 751217932 XM_011163680.1 98 1.0936e-40 PREDICTED: Solenopsis invicta uncharacterized LOC105197370 (LOC105197370), transcript variant X2, mRNA K10876 RAD54L2 RAD54-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10876 A4IHD2 1326 3.4e-144 Helicase ARIP4 OS=Xenopus tropicalis GN=rad54l2 PE=2 SV=1 PF01284//PF04851//PF00176 Membrane-associating domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0005524//GO:0016787//GO:0003677 ATP binding//hydrolase activity//DNA binding GO:0016020 membrane KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.31843 BF_2 368.69 2.22 7224 642935013 XP_008199906.1 2193 2.4e-243 PREDICTED: helicase ARIP4 isoform X1 [Tribolium castaneum] 751217932 XM_011163680.1 98 1.09543e-40 PREDICTED: Solenopsis invicta uncharacterized LOC105197370 (LOC105197370), transcript variant X2, mRNA K10876 RAD54L2 RAD54-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10876 A4IHD2 1326 3.4e-144 Helicase ARIP4 OS=Xenopus tropicalis GN=rad54l2 PE=2 SV=1 PF01284//PF04851//PF00176 Membrane-associating domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding GO:0016020 membrane KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.31844 BF_2 54.15 0.35 6682 189241560 XP_001809966.1 1592 1.1e-173 PREDICTED: rab GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ17 914 1.9e-96 Rab GTPase-activating protein 1-like OS=Gallus gallus GN=RABGAP1L PE=2 SV=1 PF07776//PF14719//PF00096//PF07660//PF16622//PF02892//PF13912//PF05443//PF00640//PF13465 Zinc-finger associated domain (zf-AD)//Phosphotyrosine interaction domain (PTB/PID)//Zinc finger, C2H2 type//Secretin and TonB N terminus short domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//ROS/MUCR transcriptional regulator protein//Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0005515//GO:0003677//GO:0008270 metal ion binding//protein binding//DNA binding//zinc ion binding GO:0019867//GO:0005634 outer membrane//nucleus -- -- Cluster-8309.31845 BF_2 20.14 0.62 1635 270004594 EFA01042.1 1514 2.9e-165 hypothetical protein TcasGA2_TC003958 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q80W31 563 2.3e-56 Zinc finger protein 569 OS=Mus musculus GN=Znf569 PE=2 SV=2 PF13465//PF00096//PF01155//PF13912//PF01363 Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//C2H2-type zinc finger//FYVE zinc finger GO:0006464 cellular protein modification process GO:0016151//GO:0046872 nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.31846 BF_2 230.00 9.94 1255 332373030 AEE61656.1 476 5.2e-45 unknown [Dendroctonus ponderosae]>gi|478251479|gb|ENN71942.1| hypothetical protein YQE_11376, partial [Dendroctonus ponderosae]>gi|546681844|gb|ERL91859.1| hypothetical protein D910_09183 [Dendroctonus ponderosae] -- -- -- -- -- K10419 DYNLRB, DNCL2 dynein light chain roadblock-type http://www.genome.jp/dbget-bin/www_bget?ko:K10419 Q32P85 391 1.5e-36 Dynein light chain roadblock-type 2 OS=Bos taurus GN=DYNLRB2 PE=3 SV=1 PF16672 Ragulator complex protein LAMTOR5 GO:0019079//GO:0043066//GO:0043154 viral genome replication//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process -- -- GO:0071986//GO:0005737 Ragulator complex//cytoplasm KOG4115 Dynein-associated protein Roadblock Cluster-8309.31847 BF_2 857.22 47.57 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31849 BF_2 151.09 2.62 2700 478251931 ENN72369.1 3261 0.0e+00 hypothetical protein YQE_11004, partial [Dendroctonus ponderosae] 195498296 XM_002096426.1 190 2.92544e-92 Drosophila yakuba GE25042 (Dyak\GE25042), partial mRNA -- -- -- -- Q8C419 156 5.9e-09 Probable G-protein coupled receptor 158 OS=Mus musculus GN=Gpr158 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.31850 BF_2 142.92 0.86 7269 91075968 XP_969381.1 1380 4.5e-149 PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|642910393|ref|XP_008190714.1| PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|270014619|gb|EFA11067.1| hypothetical protein TcasGA2_TC004663 [Tribolium castaneum] -- -- -- -- -- K03522 fixB, etfA electron transfer flavoprotein alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03522 P13803 751 1.6e-77 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Rattus norvegicus GN=Etfa PE=1 SV=4 PF04083//PF12740//PF16987//PF03403//PF00326//PF07819//PF07224//PF02230//PF06821//PF15453 Partial alpha/beta-hydrolase lipase region//Chlorophyllase enzyme//KIX domain//Platelet-activating factor acetylhydrolase, isoform II//Prolyl oligopeptidase family//PGAP1-like protein//Chlorophyllase//Phospholipase/Carboxylesterase//Serine hydrolase//Protein incorporated later into Tight Junctions GO:0006508//GO:0016042//GO:0006629//GO:0015994//GO:0006355//GO:0046486//GO:0015996//GO:0006505//GO:0006886 proteolysis//lipid catabolic process//lipid metabolic process//chlorophyll metabolic process//regulation of transcription, DNA-templated//glycerolipid metabolic process//chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport GO:0016788//GO:0047746//GO:0003712//GO:0008236//GO:0003847//GO:0016787 hydrolase activity, acting on ester bonds//chlorophyllase activity//transcription cofactor activity//serine-type peptidase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247//GO:0005667//GO:0005923 1-alkyl-2-acetylglycerophosphocholine esterase complex//transcription factor complex//bicellular tight junction KOG3954 Electron transfer flavoprotein, alpha subunit Cluster-8309.31851 BF_2 3287.00 371.77 657 91081217 XP_975622.1 483 4.2e-46 PREDICTED: ecdysteroid-regulated 16 kDa protein [Tribolium castaneum]>gi|270006449|gb|EFA02897.1| hypothetical protein TcasGA2_TC008202 [Tribolium castaneum] -- -- -- -- -- K13443 NPC2 Niemann-Pick C2 protein http://www.genome.jp/dbget-bin/www_bget?ko:K13443 Q9VQ62 378 2.6e-35 Protein NPC2 homolog OS=Drosophila melanogaster GN=Npc2a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31855 BF_2 750.30 10.02 3420 546682487 ERL92410.1 2376 6.8e-265 hypothetical protein D910_09724 [Dendroctonus ponderosae] 198451987 XM_001358537.2 567 0 Drosophila pseudoobscura pseudoobscura GA21805 (Dpse\GA21805), partial mRNA K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q86XK2 2044 8.8e-228 F-box only protein 11 OS=Homo sapiens GN=FBXO11 PE=1 SV=3 PF03284//PF02207 Phenazine biosynthesis protein A/B//Putative zinc finger in N-recognin (UBR box) GO:0017000 antibiotic biosynthetic process GO:0008270 zinc ion binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.31856 BF_2 301.15 2.97 4534 270010664 EFA07112.1 2150 1.5e-238 hypothetical protein TcasGA2_TC010102 [Tribolium castaneum] -- -- -- -- -- K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q7TPD1 1170 2.6e-126 F-box only protein 11 OS=Mus musculus GN=Fbxo11 PE=1 SV=3 PF12937//PF00646//PF15966 F-box-like//F-box domain//F-box -- -- GO:0005515 protein binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.31857 BF_2 422.30 4.65 4086 546682487 ERL92410.1 2376 8.2e-265 hypothetical protein D910_09724 [Dendroctonus ponderosae] 198451987 XM_001358537.2 567 0 Drosophila pseudoobscura pseudoobscura GA21805 (Dpse\GA21805), partial mRNA K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q86XK2 2044 1.1e-227 F-box only protein 11 OS=Homo sapiens GN=FBXO11 PE=1 SV=3 PF03284//PF02207//PF07839 Phenazine biosynthesis protein A/B//Putative zinc finger in N-recognin (UBR box)//Plant calmodulin-binding domain GO:0017000 antibiotic biosynthetic process GO:0008270//GO:0005516 zinc ion binding//calmodulin binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.31858 BF_2 5.49 0.43 817 270005507 EFA01955.1 248 9.3e-19 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P30104 170 4.2e-11 Glutathione S-transferase 1-1 OS=Drosophila erecta GN=GstD1 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31859 BF_2 201.99 2.20 4121 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31860 BF_2 152.00 14.10 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31861 BF_2 24.90 1.12 1217 91084021 XP_975350.1 307 2.0e-25 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 820852256 XM_003694739.2 73 1.42348e-27 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX23 (LOC100863532), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q5RC67 212 8.5e-16 Probable ATP-dependent RNA helicase DDX23 OS=Pongo abelii GN=DDX23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.31862 BF_2 57.58 0.33 7639 642928815 XP_967995.2 622 3.7e-61 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 159 7.5e-09 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31864 BF_2 1585.71 21.80 3330 91089287 XP_971047.1 1012 9.7e-107 PREDICTED: derlin-2 [Tribolium castaneum]>gi|270012498|gb|EFA08946.1| hypothetical protein TcasGA2_TC006653 [Tribolium castaneum] 762105781 XR_901040.1 45 1.45692e-11 PREDICTED: Crassostrea gigas derlin-2-like (LOC105333927), transcript variant X2, misc_RNA K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q8BNI4 871 8.9e-92 Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 PF01694//PF01277 Rhomboid family//Oleosin -- -- GO:0004252 serine-type endopeptidase activity GO:0016021//GO:0012511 integral component of membrane//monolayer-surrounded lipid storage body KOG0858 Predicted membrane protein Cluster-8309.31865 BF_2 49.72 0.68 3361 270014633 EFA11081.1 1997 5.9e-221 hypothetical protein TcasGA2_TC004677 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 245 3.5e-19 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31866 BF_2 233.39 2.05 5044 546674614 ERL85963.1 835 4.9e-86 hypothetical protein D910_03378 [Dendroctonus ponderosae] 597798758 XM_007260859.1 49 1.3237e-13 PREDICTED: Astyanax mexicanus superoxide dismutase 2, mitochondrial (sod2), mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 P31161 726 8.8e-75 Superoxide dismutase [Mn] 1, mitochondrial OS=Caenorhabditis elegans GN=sod-2 PE=1 SV=1 PF02777//PF02285//PF04506//PF16672//PF00081 Iron/manganese superoxide dismutases, C-terminal domain//Cytochrome oxidase c subunit VIII//Rft protein//Ragulator complex protein LAMTOR5//Iron/manganese superoxide dismutases, alpha-hairpin domain GO:0019079//GO:0006123//GO:0055114//GO:0015992//GO:0006869//GO:0043066//GO:0043154//GO:0006801 viral genome replication//mitochondrial electron transport, cytochrome c to oxygen//oxidation-reduction process//proton transport//lipid transport//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//superoxide metabolic process GO:0004784//GO:0005319//GO:0046872//GO:0004129 superoxide dismutase activity//lipid transporter activity//metal ion binding//cytochrome-c oxidase activity GO:0016021//GO:0005737//GO:0045277//GO:0071986 integral component of membrane//cytoplasm//respiratory chain complex IV//Ragulator complex KOG0876 Manganese superoxide dismutase Cluster-8309.31867 BF_2 2379.61 25.47 4196 546674614 ERL85963.1 835 4.1e-86 hypothetical protein D910_03378 [Dendroctonus ponderosae] 597798758 XM_007260859.1 49 1.09956e-13 PREDICTED: Astyanax mexicanus superoxide dismutase 2, mitochondrial (sod2), mRNA K04564 SOD2 superoxide dismutase, Fe-Mn family http://www.genome.jp/dbget-bin/www_bget?ko:K04564 P31161 726 7.3e-75 Superoxide dismutase [Mn] 1, mitochondrial OS=Caenorhabditis elegans GN=sod-2 PE=1 SV=1 PF16672//PF00081//PF04923//PF02777//PF04506 Ragulator complex protein LAMTOR5//Iron/manganese superoxide dismutases, alpha-hairpin domain//Ninjurin//Iron/manganese superoxide dismutases, C-terminal domain//Rft protein GO:0006801//GO:0007155//GO:0055114//GO:0043154//GO:0019079//GO:0006869//GO:0043066//GO:0042246 superoxide metabolic process//cell adhesion//oxidation-reduction process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//viral genome replication//lipid transport//negative regulation of apoptotic process//tissue regeneration GO:0046872//GO:0005319//GO:0004784 metal ion binding//lipid transporter activity//superoxide dismutase activity GO:0005737//GO:0016021//GO:0071986 cytoplasm//integral component of membrane//Ragulator complex KOG0876 Manganese superoxide dismutase Cluster-8309.31868 BF_2 40.46 0.33 5362 158148985 BAF82026.1 144 7.0e-06 piggyBac transposase Uribo2 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31869 BF_2 480.98 39.31 799 332372879 AEE61581.1 508 6.4e-49 unknown [Dendroctonus ponderosae]>gi|478254197|gb|ENN74466.1| hypothetical protein YQE_08957, partial [Dendroctonus ponderosae] 665790676 XM_008562812.1 141 1.45727e-65 PREDICTED: Microplitis demolitor histone H2A.V (LOC103580890), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P08991 492 1.9e-48 Histone H2A.V (Fragment) OS=Strongylocentrotus purpuratus GN=H2A.F/Z PE=1 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1757 Histone 2A Cluster-8309.3187 BF_2 17.92 0.39 2219 642931828 XP_971231.2 1133 6.0e-121 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q0VD31 378 8.7e-35 F-box/LRR-repeat protein 4 OS=Bos taurus GN=FBXL4 PE=2 SV=1 PF15966//PF00646//PF00560//PF12937//PF13516 F-box//F-box domain//Leucine Rich Repeat//F-box-like//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.31871 BF_2 266.00 5.27 2398 642929315 XP_008195783.1 1357 6.9e-147 PREDICTED: uncharacterized protein LOC103312132 [Tribolium castaneum]>gi|270009640|gb|EFA06088.1| hypothetical protein TcasGA2_TC008925 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31872 BF_2 1441.41 13.49 4758 642932256 XP_008197035.1 1291 6.2e-139 PREDICTED: uncharacterized protein CG7065 homolog isoform X2 [Tribolium castaneum] 805785462 XM_012284975.1 63 2.05918e-21 PREDICTED: Megachile rotundata uncharacterized protein CG7065-like (LOC100874663), transcript variant X3, mRNA -- -- -- -- Q7YZA2 382 6.4e-35 Uncharacterized protein CG7065 OS=Drosophila melanogaster GN=CG7065 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31874 BF_2 12.70 0.60 1180 704178438 XP_010134461.1 314 3.0e-26 PREDICTED: ras-related protein Rab-2A isoform X2 [Buceros rhinoceros silvestris] -- -- -- -- -- K07877 RAB2A Ras-related protein Rab-2A http://www.genome.jp/dbget-bin/www_bget?ko:K07877 P53994 301 3.9e-26 Ras-related protein Rab-2A OS=Mus musculus GN=Rab2a PE=1 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.31875 BF_2 70.16 0.58 5377 642940400 XP_008200547.1 1877 7.8e-207 PREDICTED: chitin deacetylase 5 isoform X8 [Tribolium castaneum] 827560342 XM_012695639.1 297 1.93779e-151 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0006807//GO:0005975//GO:0006030 nitrogen compound metabolic process//carbohydrate metabolic process//chitin metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.31876 BF_2 248.35 1.46 7426 642932804 XP_008196990.1 7051 0.0e+00 PREDICTED: myosin heavy chain, non-muscle isoform X1 [Tribolium castaneum] 462326123 APGK01041549.1 824 0 Dendroctonus ponderosae Seq01041559, whole genome shotgun sequence K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 5930 0.0e+00 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF08471//PF01576//PF00612//PF00063 Class II vitamin B12-dependent ribonucleotide reductase//Myosin tail//IQ calmodulin-binding motif//Myosin head (motor domain) GO:0006206//GO:0055114//GO:0009186//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0003774//GO:0050897//GO:0005524//GO:0004748//GO:0005515 motor activity//cobalt ion binding//ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//protein binding GO:0016459//GO:0005971 myosin complex//ribonucleoside-diphosphate reductase complex KOG0161 Myosin class II heavy chain Cluster-8309.31877 BF_2 57.00 0.59 4314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31878 BF_2 551.00 37.86 896 91077462 XP_968036.1 713 1.2e-72 PREDICTED: prefoldin subunit 3 [Tribolium castaneum]>gi|270002137|gb|EEZ98584.1| hypothetical protein TcasGA2_TC001098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGP6 476 1.5e-46 Prefoldin subunit 3 OS=Drosophila melanogaster GN=mgr PE=1 SV=3 PF01920//PF12761 Prefoldin subunit//Actin cytoskeleton-regulatory complex protein END3 GO:0006897//GO:0007015//GO:0006457 endocytosis//actin filament organization//protein folding GO:0051082 unfolded protein binding GO:0016272 prefoldin complex KOG3313 Molecular chaperone Prefoldin, subunit 3 Cluster-8309.3188 BF_2 7.00 0.47 914 642923095 XP_008193607.1 302 5.7e-25 PREDICTED: uncharacterized protein LOC103313077 [Tribolium castaneum]>gi|270007636|gb|EFA04084.1| hypothetical protein TcasGA2_TC014318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31880 BF_2 148.00 3.49 2061 91087075 XP_974896.1 1525 2.0e-166 PREDICTED: nucleoporin GLE1 [Tribolium castaneum]>gi|642929462|ref|XP_008195850.1| PREDICTED: nucleoporin GLE1 [Tribolium castaneum]>gi|270009615|gb|EFA06063.1| hypothetical protein TcasGA2_TC008898 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4W1 583 1.4e-58 Nucleoporin GLE1 OS=Drosophila melanogaster GN=GLE1 PE=2 SV=1 PF07817 GLE1-like protein GO:0016973 poly(A)+ mRNA export from nucleus -- -- GO:0005643 nuclear pore KOG2412 Nuclear-export-signal (NES)-containing protein/polyadenylated-RNA export factor Cluster-8309.31881 BF_2 5.53 0.70 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31882 BF_2 263.77 20.18 834 91076494 XP_972946.1 541 1.0e-52 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 394 4.6e-37 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.31886 BF_2 872.16 14.31 2837 91092168 XP_968081.1 571 1.1e-55 PREDICTED: uncharacterized protein LOC656458 [Tribolium castaneum]>gi|270014443|gb|EFA10891.1| hypothetical protein TcasGA2_TC001715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.31887 BF_2 791.56 22.41 1765 91090488 XP_968919.1 1931 1.4e-213 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X2 [Tribolium castaneum]>gi|270013864|gb|EFA10312.1| hypothetical protein TcasGA2_TC012528 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q02157 633 1.9e-64 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- GO:0016042//GO:0046486//GO:0006629 lipid catabolic process//glycerolipid metabolic process//lipid metabolic process GO:0004806 triglyceride lipase activity GO:0005576 extracellular region -- -- Cluster-8309.31889 BF_2 40.14 0.36 4900 642934565 XP_008197717.1 3673 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 7.0e-93 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF00069//PF06293//PF04265//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Thiamin pyrophosphokinase, vitamin B1 binding domain//Protein tyrosine kinase GO:0009229//GO:0006468 thiamine diphosphate biosynthetic process//protein phosphorylation GO:0000166//GO:0016773//GO:0004672//GO:0030975//GO:0005524 nucleotide binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//thiamine binding//ATP binding GO:0016020 membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.31890 BF_2 686.25 4.72 6370 91078794 XP_970038.1 3616 0.0e+00 PREDICTED: WD repeat-containing protein 3 [Tribolium castaneum]>gi|270003730|gb|EFA00178.1| hypothetical protein TcasGA2_TC003001 [Tribolium castaneum] 642916053 XR_511345.1 322 2.90894e-165 PREDICTED: Tribolium castaneum uncharacterized LOC100141824 (LOC100141824), transcript variant X2, misc_RNA K14556 DIP2, UTP12, WDR3 U3 small nucleolar RNA-associated protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14556 Q9UNX4 2070 1.6e-230 WD repeat-containing protein 3 OS=Homo sapiens GN=WDR3 PE=1 SV=1 PF00400//PF00008//PF04494 WD domain, G-beta repeat//EGF-like domain//WD40 associated region in TFIID subunit, NTD2 domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0306 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.31891 BF_2 59.00 0.90 3034 254939725 ACT88125.1 765 3.9e-78 AT15141p [Drosophila melanogaster] 427776119 JX855312.1 1811 0 Portunus trituberculatus calmodulin (CaM) mRNA, complete cds K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P62153 758 1.0e-78 Calmodulin-A OS=Halocynthia roretzi PE=1 SV=2 PF02627//PF13499//PF13833//PF10591//PF13405//PF12763//PF02563//PF00036//PF03874//PF13202 Carboxymuconolactone decarboxylase family//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Cytoskeletal-regulatory complex EF hand//Polysaccharide biosynthesis/export protein//EF hand//RNA polymerase Rpb4//EF hand GO:0007165//GO:0006351//GO:0015774//GO:0006144//GO:0006206//GO:0055114 signal transduction//transcription, DNA-templated//polysaccharide transport//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0051920//GO:0003899//GO:0005515//GO:0015159//GO:0005509 peroxiredoxin activity//DNA-directed RNA polymerase activity//protein binding//polysaccharide transmembrane transporter activity//calcium ion binding GO:0016020//GO:0005578//GO:0005730 membrane//proteinaceous extracellular matrix//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.31892 BF_2 702.00 12.94 2556 332372973 AEE61628.1 1568 2.5e-171 unknown [Dendroctonus ponderosae]>gi|478253498|gb|ENN73825.1| hypothetical protein YQE_09603, partial [Dendroctonus ponderosae]>gi|546679120|gb|ERL89625.1| hypothetical protein D910_06990 [Dendroctonus ponderosae] 815776040 XM_012358994.1 116 3.79087e-51 PREDICTED: Linepithema humile innexin inx1 (LOC105680188), mRNA -- -- -- -- Q9XYN0 1453 2.2e-159 Innexin inx1 OS=Schistocerca americana GN=inx1 PE=1 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.31895 BF_2 14.00 0.95 902 195131405 XP_002010141.1 220 1.8e-15 GI15765 [Drosophila mojavensis]>gi|193908591|gb|EDW07458.1| GI15765 [Drosophila mojavensis] -- -- -- -- -- K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 -- -- -- -- PF03051 Peptidase C1-like family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.31898 BF_2 96.72 3.26 1528 189240395 XP_967842.2 1865 5.5e-206 PREDICTED: lissencephaly-1 homolog [Tribolium castaneum] 195056833 XM_001995131.1 83 4.96392e-33 Drosophila grimshawi GH22777 (Dgri\GH22777), mRNA K16794 PAFAH1B1, LIS1 platelet-activating factor acetylhydrolase IB subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16794 Q7KNS3 1709 2.8e-189 Lissencephaly-1 homolog OS=Drosophila melanogaster GN=Lis-1 PE=1 SV=2 PF04508//PF08513//PF00400 Viral A-type inclusion protein repeat//LisH//WD domain, G-beta repeat GO:0016032 viral process GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.31899 BF_2 1217.30 25.88 2255 332372580 AEE61432.1 1838 1.1e-202 unknown [Dendroctonus ponderosae]>gi|478260722|gb|ENN80403.1| hypothetical protein YQE_03175, partial [Dendroctonus ponderosae] -- -- -- -- -- K00825 AADAT, KAT2 kynurenine/2-aminoadipate aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00825 Q5E9N4 891 2.9e-94 Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial OS=Bos taurus GN=AADAT PE=2 SV=1 PF00155//PF01212//PF01053 Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0634 Aromatic amino acid aminotransferase and related proteins Cluster-8309.31901 BF_2 35.69 0.36 4395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02901 Pyruvate formate lyase-like -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.31902 BF_2 188.85 7.28 1373 642925464 XP_008194565.1 397 8.2e-36 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.31905 BF_2 4546.00 3279.52 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31906 BF_2 680.11 5.80 5192 642918013 XP_008198979.1 1028 2.1e-108 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 744 7.4e-77 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF00034//PF02167//PF13442 Cytochrome c//Cytochrome C1 family//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0005488//GO:0009055//GO:0020037 binding//electron carrier activity//heme binding -- -- KOG3052 Cytochrome c1 Cluster-8309.31907 BF_2 199.07 4.68 2065 642923805 XP_008193890.1 1839 7.6e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 4.0e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.31908 BF_2 43.84 1.02 2093 642913503 XP_008201041.1 960 6.5e-101 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 Q91YJ2 499 7.7e-49 Sorting nexin-4 OS=Mus musculus GN=Snx4 PE=2 SV=1 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.31909 BF_2 334.09 1.97 7388 642918367 XP_008200036.1 2521 2.3e-281 PREDICTED: titin-like isoform X1 [Tribolium castaneum] 462348959 APGK01033436.1 65 2.47733e-22 Dendroctonus ponderosae Seq01033446, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31914 BF_2 793.82 30.53 1375 741829289 AJA91071.1 1024 1.6e-108 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 734 2.8e-76 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.31915 BF_2 5.29 0.48 753 478255840 ENN76048.1 275 6.3e-22 hypothetical protein YQE_07421, partial [Dendroctonus ponderosae]>gi|546680467|gb|ERL90733.1| hypothetical protein D910_08080 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16692 Folliculin C-terminal domain GO:0043087 regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.31917 BF_2 35.85 0.42 3826 91083817 XP_973463.1 602 3.9e-59 PREDICTED: large neutral amino acids transporter small subunit 2 [Tribolium castaneum]>gi|270006773|gb|EFA03221.1| hypothetical protein TcasGA2_TC013142 [Tribolium castaneum] -- -- -- -- -- K13780 SLC7A5, LAT1 solute carrier family 7 (L-type amino acid transporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13780 Q01650 398 7.2e-37 Large neutral amino acids transporter small subunit 1 OS=Homo sapiens GN=SLC7A5 PE=1 SV=2 PF13520//PF03222//PF00324 Amino acid permease//Tryptophan/tyrosine permease family//Amino acid permease GO:0006865//GO:0055085//GO:0003333//GO:0006810 amino acid transport//transmembrane transport//amino acid transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1287 Amino acid transporters Cluster-8309.31919 BF_2 46.50 26.08 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00719 Inorganic pyrophosphatase GO:0006796//GO:0006119 phosphate-containing compound metabolic process//oxidative phosphorylation GO:0004427//GO:0000287 inorganic diphosphatase activity//magnesium ion binding GO:0005737 cytoplasm -- -- Cluster-8309.31920 BF_2 10.58 0.35 1544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31923 BF_2 389.28 2.17 7788 189241335 XP_001809545.1 1796 2.8e-197 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 416 0 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 1318 3.1e-143 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF06662//PF01292//PF00876 D-glucuronyl C5-epimerase C-terminus//Prokaryotic cytochrome b561//Innexin GO:0006024//GO:0006118 glycosaminoglycan biosynthetic process//obsolete electron transport GO:0016857//GO:0009055 racemase and epimerase activity, acting on carbohydrates and derivatives//electron carrier activity GO:0005921//GO:0016021 gap junction//integral component of membrane -- -- Cluster-8309.31924 BF_2 585.95 7.68 3478 642938660 XP_972301.2 1732 3.3e-190 PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum]>gi|642938662|ref|XP_008197697.1| PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum]>gi|642938664|ref|XP_008197706.1| PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00819 rocD, OAT ornithine--oxo-acid transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00819 Q9VW26 1401 3.3e-153 Ornithine aminotransferase, mitochondrial OS=Drosophila melanogaster GN=Oat PE=2 SV=1 PF00202 Aminotransferase class-III -- -- GO:0008483//GO:0030170 transaminase activity//pyridoxal phosphate binding -- -- KOG1402 Ornithine aminotransferase Cluster-8309.31925 BF_2 399.47 7.18 2616 189238377 XP_001808976.1 1154 2.6e-123 PREDICTED: uncharacterized protein LOC100141756 [Tribolium castaneum]>gi|270008562|gb|EFA05010.1| hypothetical protein TcasGA2_TC015091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31926 BF_2 244.77 2.17 4995 91084129 XP_969781.1 3731 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 75 4.61528e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1271 5.6e-138 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF01926//PF13304//PF07728//PF02456//PF00005//PF03193//PF06552 ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//AAA domain (dynein-related subfamily)//Adenovirus IVa2 protein//ABC transporter//Protein of unknown function, DUF258//Plant specific mitochondrial import receptor subunit TOM20 GO:0045040//GO:0009987//GO:0019083//GO:0055085//GO:0006810 protein import into mitochondrial outer membrane//cellular process//viral transcription//transmembrane transport//transport GO:0005525//GO:0000166//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//nucleotide binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane -- -- Cluster-8309.31927 BF_2 13.65 0.43 1627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3193 BF_2 6.51 0.36 1046 270007707 EFA04155.1 1393 2.0e-151 hypothetical protein TcasGA2_TC014400 [Tribolium castaneum] 170055942 XM_001863773.1 170 1.45898e-81 Culex quinquefasciatus lim homeobox protein, mRNA K09374 LHX3_4 LIM homeobox protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K09374 P36200 845 2.9e-89 LIM/homeobox protein Lhx3 OS=Xenopus laevis GN=lhx3 PE=1 SV=1 PF00046//PF00412//PF05920 Homeobox domain//LIM domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.31932 BF_2 68.48 0.40 7452 642917231 XP_008191173.1 2074 1.6e-229 PREDICTED: thioredoxin reductase 2, mitochondrial isoform X2 [Tribolium castaneum] 195396538 XM_002056853.1 42 1.52538e-09 Drosophila virilis GJ16646 (Dvir\GJ16646), mRNA K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 P91938 1574 6.1e-173 Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 PE=1 SV=2 PF12831//PF00106//PF01494//PF02852//PF07992//PF01296//PF01134//PF02558//PF04369//PF00070//PF06268//PF01979//PF03435//PF01266//PF05699 FAD dependent oxidoreductase//short chain dehydrogenase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase//Galanin//Glucose inhibited division protein A//Ketopantoate reductase PanE/ApbA//Lactococcin-like family//Pyridine nucleotide-disulphide oxidoreductase//Fascin domain//Amidohydrolase family//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//hAT family C-terminal dimerisation region GO:0055114//GO:0008033//GO:0007165//GO:0015940//GO:0042742//GO:0045454//GO:0008152 oxidation-reduction process//tRNA processing//signal transduction//pantothenate biosynthetic process//defense response to bacterium//cell redox homeostasis//metabolic process GO:0051015//GO:0071949//GO:0016787//GO:0030674//GO:0050660//GO:0008677//GO:0046983//GO:0005179//GO:0016491 actin filament binding//FAD binding//hydrolase activity//protein binding, bridging//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//protein dimerization activity//hormone activity//oxidoreductase activity GO:0005576 extracellular region KOG4716 Thioredoxin reductase Cluster-8309.31936 BF_2 380.06 3.81 4457 546681097 ERL91253.1 2497 8.3e-279 hypothetical protein D910_08588 [Dendroctonus ponderosae] 820837626 XM_003690680.2 92 1.45907e-37 PREDICTED: Apis florea syntaxin-5 (LOC100868396), mRNA -- -- -- -- Q24179 2001 1.1e-222 Protein sly1 homolog OS=Drosophila melanogaster GN=Slh PE=2 SV=4 PF16519//PF00804//PF00995//PF05739//PF08131//PF00992 Tetramerisation domain of TRPM//Syntaxin//Sec1 family//SNARE domain//Defensin-like peptide family//Troponin GO:0051262//GO:0016192//GO:0006904 protein tetramerization//vesicle-mediated transport//vesicle docking involved in exocytosis GO:0005515 protein binding GO:0016020//GO:0005576//GO:0005861 membrane//extracellular region//troponin complex KOG1301 Vesicle trafficking protein Sly1 (Sec1 family) Cluster-8309.31937 BF_2 422.26 4.63 4102 642925014 XP_008194135.1 4669 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X5 [Tribolium castaneum] 759033714 XM_011331771.1 146 1.28614e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X2, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3858 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03293//PF15014//PF03485//PF05236//PF03540 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Ceroid-lipofuscinosis neuronal protein 5//Arginyl tRNA synthetase N terminal domain//Transcription initiation factor TFIID component TAF4 family//Transcription initiation factor TFIID 23-30kDa subunit GO:0006420//GO:0006525//GO:0019083//GO:0022008//GO:0006206//GO:0006352//GO:0006351//GO:0006144//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//viral transcription//neurogenesis//pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation//transcription, DNA-templated//purine nucleobase metabolic process//proline metabolic process GO:0000166//GO:0005524//GO:0003899//GO:0003677//GO:0004814 nucleotide binding//ATP binding//DNA-directed RNA polymerase activity//DNA binding//arginine-tRNA ligase activity GO:0005764//GO:0005669//GO:0005730//GO:0005737//GO:0005634 lysosome//transcription factor TFIID complex//nucleolus//cytoplasm//nucleus KOG3635 Phosphorylase kinase Cluster-8309.31939 BF_2 1063.00 19.03 2624 91078628 XP_966496.1 2433 1.3e-271 PREDICTED: septin-7 [Tribolium castaneum]>gi|270004061|gb|EFA00509.1| hypothetical protein TcasGA2_TC003373 [Tribolium castaneum] 508228 U08103.1 245 7.57868e-123 DMU08103 Drosophila melanogaster Peanut (pnut) mRNA, complete cds K16944 SEPT7, CDC3 septin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K16944 P40797 1589 3.9e-175 Protein peanut OS=Drosophila melanogaster GN=pnut PE=1 SV=2 PF03193//PF00735//PF00005//PF01926//PF10186//PF04548//PF00071 Protein of unknown function, DUF258//Septin//ABC transporter//50S ribosome-binding GTPase//Vacuolar sorting 38 and autophagy-related subunit 14//AIG1 family//Ras family GO:0010508//GO:0007264//GO:0007049 positive regulation of autophagy//small GTPase mediated signal transduction//cell cycle GO:0003924//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ATP binding//GTP binding//ATPase activity -- -- KOG2655 Septin family protein (P-loop GTPase) Cluster-8309.31942 BF_2 295.46 2.75 4786 189237113 XP_971629.2 1209 2.0e-129 PREDICTED: xyloside xylosyltransferase 1 [Tribolium castaneum]>gi|270007231|gb|EFA03679.1| hypothetical protein TcasGA2_TC013781 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBI6 600 3.4e-60 Xyloside xylosyltransferase 1 OS=Homo sapiens GN=XXYLT1 PE=1 SV=1 PF13499//PF13405//PF13833//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0016757//GO:0005509//GO:0005515 transferase activity, transferring glycosyl groups//calcium ion binding//protein binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.31943 BF_2 44.17 0.38 5126 91091688 XP_972411.1 1271 1.4e-136 PREDICTED: carbohydrate sulfotransferase 5 [Tribolium castaneum]>gi|270001059|gb|EEZ97506.1| hypothetical protein TcasGA2_TC011350 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QUP4 261 7.5e-21 Carbohydrate sulfotransferase 5 OS=Mus musculus GN=Chst5 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.31944 BF_2 11.00 1.34 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.31946 BF_2 452.00 10.49 2089 189233943 XP_974086.2 1977 7.7e-219 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R5X9 220 1.7e-16 SET and MYND domain-containing protein 4 OS=Pongo abelii GN=SMYD4 PE=2 SV=1 PF00856//PF13414//PF13181 SET domain//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.31947 BF_2 75.36 1.90 1946 189236857 XP_974302.2 547 4.7e-53 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 243 3.5e-19 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 PF03222 Tryptophan/tyrosine permease family GO:0003333 amino acid transmembrane transport -- -- -- -- -- -- Cluster-8309.31948 BF_2 271.23 6.33 2081 478256367 ENN76557.1 2591 4.9e-290 hypothetical protein YQE_07008, partial [Dendroctonus ponderosae] -- -- -- -- -- K10455 KLHL18 kelch-like protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K10455 O94889 1471 1.5e-161 Kelch-like protein 18 OS=Homo sapiens GN=KLHL18 PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.31949 BF_2 195.21 2.46 3611 642936594 XP_008198499.1 1421 3.9e-154 PREDICTED: solute carrier family 2, facilitated glucose transporter member 1-like isoform X2 [Tribolium castaneum]>gi|270014149|gb|EFA10597.1| hypothetical protein TcasGA2_TC012857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13355 670 2.0e-68 Solute carrier family 2, facilitated glucose transporter member 1 OS=Oryctolagus cuniculus GN=SLC2A1 PE=2 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.31950 BF_2 174.06 2.08 3783 91079768 XP_966889.1 792 3.6e-81 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 385 2.3e-35 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF01073//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0055114//GO:0006694//GO:0008209//GO:0008207//GO:0008210//GO:0008152 oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0016491//GO:0016616//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.31951 BF_2 63.29 6.19 715 642922046 XP_008192998.1 213 9.3e-15 PREDICTED: lysosome-associated membrane glycoprotein 1, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11857//PF01299 Domain of unknown function (DUF3377)//Lysosome-associated membrane glycoprotein (Lamp) -- -- GO:0004222 metalloendopeptidase activity GO:0016020 membrane -- -- Cluster-8309.31955 BF_2 56.97 0.82 3193 546681102 ERL91258.1 1088 1.4e-115 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P34410 177 2.6e-11 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF01573 Bromovirus movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0044156 host cell junction -- -- Cluster-8309.31957 BF_2 266.78 3.53 3447 642933985 XP_008197592.1 1968 1.4e-217 PREDICTED: histone acetyltransferase KAT6A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3YXK1 194 2.9e-13 Atherin OS=Mus musculus GN=Samd1 PE=1 SV=1 PF00628//PF16866//PF02198//PF05715//PF13639//PF00536 PHD-finger//PHD-finger//Sterile alpha motif (SAM)/Pointed domain//Piccolo Zn-finger//Ring finger domain//SAM domain (Sterile alpha motif) -- -- GO:0043565//GO:0008270//GO:0046872//GO:0005515 sequence-specific DNA binding//zinc ion binding//metal ion binding//protein binding GO:0005634//GO:0045202 nucleus//synapse -- -- Cluster-8309.31958 BF_2 270.77 2.28 5256 642914506 XP_008201705.1 1739 7.7e-191 PREDICTED: protein RUFY3 isoform X4 [Tribolium castaneum]>gi|270001486|gb|EEZ97933.1| hypothetical protein TcasGA2_TC000321 [Tribolium castaneum] 749749484 XM_011138657.1 86 3.72914e-34 PREDICTED: Harpegnathos saltator protein RUFY3 (LOC105181701), transcript variant X2, mRNA -- -- -- -- Q5R5R4 925 7.7e-98 RUN and FYVE domain-containing protein 2 OS=Pongo abelii GN=RUFY2 PE=2 SV=1 PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.31961 BF_2 108.49 5.12 1173 642927772 XP_008195399.1 282 1.5e-22 PREDICTED: receptor-type tyrosine-protein phosphatase F-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MBJ4 165 2.3e-10 Receptor-type tyrosine-protein phosphatase F OS=Bos taurus GN=PTPRF PE=2 SV=1 PF16656//PF00041//PF03425 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Carbohydrate binding domain (family 11) GO:0019497//GO:0005982//GO:0005985//GO:0030245//GO:0006771 hexachlorocyclohexane metabolic process//starch metabolic process//sucrose metabolic process//cellulose catabolic process//riboflavin metabolic process GO:0005515//GO:0008810//GO:0046872//GO:0003993 protein binding//cellulase activity//metal ion binding//acid phosphatase activity -- -- -- -- Cluster-8309.31962 BF_2 3.00 0.74 457 642927770 XP_008195398.1 146 3.5e-07 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31963 BF_2 221.24 1.85 5278 665804096 XP_008550173.1 2041 7.4e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 189008483 EU616810.1 323 6.6967e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 3.9e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF13374//PF01092//PF00520//PF00060//PF02214 Tetratricopeptide repeat//Ribosomal protein S6e//Ion transport protein//Ligand-gated ion channel//BTB/POZ domain GO:0055085//GO:0007165//GO:0006412//GO:0051260//GO:0007268//GO:0006811//GO:0042254 transmembrane transport//signal transduction//translation//protein homooligomerization//synaptic transmission//ion transport//ribosome biogenesis GO:0005515//GO:0004970//GO:0005216//GO:0003735 protein binding//ionotropic glutamate receptor activity//ion channel activity//structural constituent of ribosome GO:0016020//GO:0005622//GO:0005840 membrane//intracellular//ribosome -- -- Cluster-8309.31964 BF_2 69.26 0.41 7388 189236205 XP_970721.2 1656 4.5e-181 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 71 1.14446e-25 Manduca sexta adipose triglyceride lipase mRNA, complete cds -- -- -- -- Q91WW7 416 1.1e-38 Patatin-like phospholipase domain-containing protein 3 OS=Mus musculus GN=Pnpla3 PE=2 SV=1 PF01734//PF00274 Patatin-like phospholipase//Fructose-bisphosphate aldolase class-I GO:0006098//GO:0006096//GO:0006020//GO:0006629//GO:0015976//GO:0006094//GO:0006000//GO:0006013 pentose-phosphate shunt//glycolytic process//inositol metabolic process//lipid metabolic process//carbon utilization//gluconeogenesis//fructose metabolic process//mannose metabolic process GO:0016787//GO:0004332 hydrolase activity//fructose-bisphosphate aldolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.31965 BF_2 59.67 0.35 7352 189236205 XP_970721.2 1656 4.5e-181 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 71 1.13886e-25 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q91WW7 415 1.5e-38 Patatin-like phospholipase domain-containing protein 3 OS=Mus musculus GN=Pnpla3 PE=2 SV=1 PF01734//PF00274 Patatin-like phospholipase//Fructose-bisphosphate aldolase class-I GO:0006013//GO:0006000//GO:0006094//GO:0015976//GO:0006629//GO:0006020//GO:0006096//GO:0006098 mannose metabolic process//fructose metabolic process//gluconeogenesis//carbon utilization//lipid metabolic process//inositol metabolic process//glycolytic process//pentose-phosphate shunt GO:0004332//GO:0016787 fructose-bisphosphate aldolase activity//hydrolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.31966 BF_2 291.00 7.04 2017 91086887 XP_970325.1 1279 6.4e-138 PREDICTED: dnaJ homolog subfamily C member 21 [Tribolium castaneum]>gi|270010477|gb|EFA06925.1| hypothetical protein TcasGA2_TC009874 [Tribolium castaneum] 690018598 LM525836.1 44 3.15391e-11 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_contig0000215 K09506 DNAJA5 DnaJ homolog subfamily A member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09506 Q5F1R6 873 3.2e-92 DnaJ homolog subfamily C member 21 OS=Homo sapiens GN=DNAJC21 PE=1 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- KOG0717 Molecular chaperone (DnaJ superfamily) Cluster-8309.31967 BF_2 2817.54 50.70 2612 91085817 XP_974784.1 2646 2.6e-296 PREDICTED: peroxisomal multifunctional enzyme type 2 isoform X1 [Tribolium castaneum]>gi|270011047|gb|EFA07495.1| hydroxysteroid (17-beta) dehydrogenase 4 [Tribolium castaneum] 642927307 XM_008196993.1 99 1.09277e-41 PREDICTED: Tribolium castaneum hydroxysteroid (17-beta) dehydrogenase 4 (LOC663655), transcript variant X2, mRNA K12405 HSD17B4 3-hydroxyacyl-CoA dehydrogenase / 3a,7a,12a-trihydroxy-5b-cholest-24-enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K12405 Q9VXJ0 1734 6.0e-192 Peroxisomal multifunctional enzyme type 2 OS=Drosophila melanogaster GN=Mfe2 PE=1 SV=1 PF02737//PF00106 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//short chain dehydrogenase GO:0006568//GO:0006631//GO:0006552//GO:0006554//GO:0055114//GO:0006574//GO:0006550//GO:0008152//GO:0018874//GO:0006633 tryptophan metabolic process//fatty acid metabolic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process//valine catabolic process//isoleucine catabolic process//metabolic process//benzoate metabolic process//fatty acid biosynthetic process GO:0003857//GO:0000166//GO:0032934//GO:0016491 3-hydroxyacyl-CoA dehydrogenase activity//nucleotide binding//sterol binding//oxidoreductase activity -- -- KOG1206 Peroxisomal multifunctional beta-oxidation protein and related enzymes Cluster-8309.31968 BF_2 783.63 8.04 4363 642921136 XP_008192702.1 1068 4.1e-113 PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921138|ref|XP_008192703.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921140|ref|XP_008192704.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921142|ref|XP_008192706.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921144|ref|XP_008192707.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921146|ref|XP_008192708.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921148|ref|XP_008192709.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921150|ref|XP_008192710.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WVB4 224 1.2e-16 Slit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2 PF13895//PF14991//PF15050//PF13855 Immunoglobulin domain//Protein melan-A//SCIMP protein//Leucine rich repeat -- -- GO:0005515 protein binding GO:0016021//GO:0001772//GO:0042470//GO:0097197 integral component of membrane//immunological synapse//melanosome//tetraspanin-enriched microdomain -- -- Cluster-8309.31969 BF_2 70.56 0.36 8483 478254915 ENN75149.1 2582 2.2e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.76705e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.7e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF00665//PF01392//PF13683//PF01534//PF08465 Integrase core domain//Fz domain//Integrase core domain//Frizzled/Smoothened family membrane region//Thymidine kinase from Herpesvirus C-terminal GO:0007166//GO:0015074//GO:0006206//GO:0006230 cell surface receptor signaling pathway//DNA integration//pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0005515//GO:0005524//GO:0004797 protein binding//ATP binding//thymidine kinase activity GO:0016020 membrane -- -- Cluster-8309.31970 BF_2 67.80 0.36 8131 478254915 ENN75149.1 2582 2.1e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.69341e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.7e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF08465//PF01392//PF01534//PF13683//PF00665 Thymidine kinase from Herpesvirus C-terminal//Fz domain//Frizzled/Smoothened family membrane region//Integrase core domain//Integrase core domain GO:0007166//GO:0015074//GO:0006206//GO:0006230 cell surface receptor signaling pathway//DNA integration//pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0005515//GO:0004797//GO:0005524 protein binding//thymidine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.31971 BF_2 616.33 5.03 5408 91094249 XP_968795.1 1078 3.5e-114 PREDICTED: neurofilament heavy polypeptide [Tribolium castaneum]>gi|270016266|gb|EFA12712.1| hypothetical protein TcasGA2_TC002346 [Tribolium castaneum] -- -- -- -- -- K00653 CDY chromodomain protein Y http://www.genome.jp/dbget-bin/www_bget?ko:K00653 Q9D5D8 286 9.9e-24 Chromodomain Y-like protein 2 OS=Mus musculus GN=Cdyl2 PE=1 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG0016 Enoyl-CoA hydratase/isomerase Cluster-8309.31972 BF_2 141.00 3.41 2017 478254874 ENN75110.1 805 5.9e-83 hypothetical protein YQE_08423, partial [Dendroctonus ponderosae] -- -- -- -- -- K07573 CSL4, EXOSC1 exosome complex component CSL4 http://www.genome.jp/dbget-bin/www_bget?ko:K07573 Q9DAA6 489 1.1e-47 Exosome complex component CSL4 OS=Mus musculus GN=Exosc1 PE=2 SV=1 PF10447 Exosome component EXOSC1/CSL4 -- -- GO:0003723 RNA binding GO:0000178 exosome (RNase complex) KOG3409 Exosomal 3'-5' exoribonuclease complex, subunit ski4 (Csl4) Cluster-8309.31974 BF_2 12.00 0.53 1236 241729762 XP_002413810.1 1601 1.8e-175 F0F1-type ATP synthase, beta subunit, putative [Ixodes scapularis]>gi|215507626|gb|EEC17118.1| F0F1-type ATP synthase, beta subunit, putative [Ixodes scapularis] 195450699 XM_002072559.1 396 0 Drosophila willistoni GK13685 (Dwil\GK13685), mRNA K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q5ZLC5 1537 2.0e-169 ATP synthase subunit beta, mitochondrial OS=Gallus gallus GN=ATP5B PE=1 SV=1 PF01637//PF00006//PF00005//PF03193//PF00931//PF02874 Archaeal ATPase//ATP synthase alpha/beta family, nucleotide-binding domain//ABC transporter//Protein of unknown function, DUF258//NB-ARC domain//ATP synthase alpha/beta family, beta-barrel domain GO:0006119//GO:0046034//GO:0015991//GO:0015992//GO:0015986 oxidative phosphorylation//ATP metabolic process//ATP hydrolysis coupled proton transport//proton transport//ATP synthesis coupled proton transport GO:0043531//GO:0003924//GO:0005524//GO:0046933//GO:0008553//GO:0005525//GO:0016887 ADP binding//GTPase activity//ATP binding//proton-transporting ATP synthase activity, rotational mechanism//hydrogen-exporting ATPase activity, phosphorylative mechanism//GTP binding//ATPase activity GO:0045261//GO:0045259 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex KOG1350 F0F1-type ATP synthase, beta subunit Cluster-8309.31975 BF_2 774.82 8.98 3896 642921248 XP_969543.2 1439 3.5e-156 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 O75420 250 1.1e-19 PERQ amino acid-rich with GYF domain-containing protein 1 OS=Homo sapiens GN=GIGYF1 PE=1 SV=2 PF02213 GYF domain -- -- GO:0005515 protein binding -- -- KOG1862 GYF domain containing proteins Cluster-8309.31977 BF_2 28.87 0.53 2565 270003285 EEZ99732.1 1425 9.6e-155 hypothetical protein TcasGA2_TC002501 [Tribolium castaneum] 780625043 XM_011709899.1 203 1.64912e-99 PREDICTED: Wasmannia auropunctata CCR4-NOT transcription complex subunit 3 (LOC105462953), mRNA K12580 CNOT3, NOT3 CCR4-NOT transcription complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12580 O75175 858 2.2e-90 CCR4-NOT transcription complex subunit 3 OS=Homo sapiens GN=CNOT3 PE=1 SV=1 PF04065//PF07352//PF04153 Not1 N-terminal domain, CCR4-Not complex component//Bacteriophage Mu Gam like protein//NOT2 / NOT3 / NOT5 family GO:0006355//GO:0042262 regulation of transcription, DNA-templated//DNA protection GO:0003690 double-stranded DNA binding GO:0005634 nucleus KOG2150 CCR4-NOT transcriptional regulation complex, NOT5 subunit Cluster-8309.31978 BF_2 526.81 8.83 2784 270012236 EFA08684.1 956 2.5e-100 hypothetical protein TcasGA2_TC006354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVV5 418 2.5e-39 Androgen-induced gene 1 protein OS=Homo sapiens GN=AIG1 PE=1 SV=2 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.31979 BF_2 991.32 26.98 1824 91088493 XP_975965.1 800 2.0e-82 PREDICTED: androgen-induced gene 1 protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVV5 420 9.7e-40 Androgen-induced gene 1 protein OS=Homo sapiens GN=AIG1 PE=1 SV=2 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.31980 BF_2 377.64 14.13 1405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04210 Tetrahydromethanopterin S-methyltransferase, subunit G GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.31981 BF_2 120.00 6.61 1047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31983 BF_2 496.35 8.10 2851 642937018 XP_008198655.1 2482 2.9e-277 PREDICTED: neutral ceramidase-like [Tribolium castaneum] -- -- -- -- -- K12349 ASAH2 neutral ceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K12349 Q9VA70 1845 8.8e-205 Neutral ceramidase OS=Drosophila melanogaster GN=CDase PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2232 Ceramidases Cluster-8309.31986 BF_2 200.00 7.30 1434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31987 BF_2 213.00 12.14 1021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31988 BF_2 186.72 0.99 8204 817053828 XP_012264100.1 1826 9.8e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935876 XR_511652.1 647 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X4, misc_RNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 Q9UBE8 1597 1.4e-175 Serine/threonine-protein kinase NLK OS=Homo sapiens GN=NLK PE=1 SV=2 PF06293//PF00069//PF07714//PF04505 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Interferon-induced transmembrane protein GO:0009607//GO:0006468 response to biotic stimulus//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.31991 BF_2 3608.00 33.42 4803 91084227 XP_969046.1 2331 1.6e-259 PREDICTED: uncharacterized protein LOC657496 [Tribolium castaneum]>gi|270009271|gb|EFA05719.1| egalitarian [Tribolium castaneum] 391343176 XM_003745841.1 42 9.80954e-10 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100902998 (LOC100902998), mRNA K18740 EXD1, EGL exonuclease 3'-5' domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18740 Q6NRD5 136 2.2e-06 Exonuclease 3'-5' domain-containing protein 1 OS=Xenopus laevis GN=exd1 PE=2 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- KOG2405 Predicted 3'-5' exonuclease Cluster-8309.31992 BF_2 2388.21 54.45 2122 91087227 XP_975491.1 2614 1.1e-292 PREDICTED: probable nucleolar GTP-binding protein 1 [Tribolium castaneum]>gi|270009559|gb|EFA06007.1| hypothetical protein TcasGA2_TC008833 [Tribolium castaneum] 820858813 XM_012490940.1 361 0 PREDICTED: Apis florea probable nucleolar GTP-binding protein 1 (LOC100863188), transcript variant X2, mRNA K06943 NOG1 nucleolar GTP-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K06943 Q9V411 2299 1.5e-257 Probable nucleolar GTP-binding protein 1 OS=Drosophila melanogaster GN=CG8801 PE=2 SV=1 PF02421//PF04548//PF06858//PF01926//PF08063//PF03193//PF08477 Ferrous iron transport protein B//AIG1 family//Nucleolar GTP-binding protein 1 (NOG1)//50S ribosome-binding GTPase//PADR1 (NUC008) domain//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0042254//GO:0007264//GO:0015684 ribosome biogenesis//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0003950//GO:0015093//GO:0003924 GTP binding//NAD+ ADP-ribosyltransferase activity//ferrous iron transmembrane transporter activity//GTPase activity GO:0005730//GO:0016021//GO:0005634 nucleolus//integral component of membrane//nucleus KOG1490 GTP-binding protein CRFG/NOG1 (ODN superfamily) Cluster-8309.31993 BF_2 1049.26 10.29 4554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31994 BF_2 540.74 11.64 2231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31995 BF_2 538.58 18.94 1477 189238011 XP_001813334.1 454 2.2e-42 PREDICTED: SH3 domain-binding glutamic acid-rich protein homolog [Tribolium castaneum]>gi|270008052|gb|EFA04500.1| hypothetical protein TcasGA2_TC014808 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NFP5 386 6.9e-36 SH3 domain-binding glutamic acid-rich protein homolog OS=Drosophila melanogaster GN=Sh3beta PE=1 SV=2 PF02932//PF00462 Neurotransmitter-gated ion-channel transmembrane region//Glutaredoxin GO:0006118//GO:0045454//GO:0006811 obsolete electron transport//cell redox homeostasis//ion transport GO:0009055//GO:0015035 electron carrier activity//protein disulfide oxidoreductase activity GO:0016020 membrane KOG4023 Uncharacterized conserved protein Cluster-8309.31996 BF_2 1008.08 11.33 4008 642930846 XP_008196111.1 677 8.2e-68 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.31997 BF_2 108.47 5.11 1176 270015668 EFA12116.1 318 1.0e-26 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11162 RDH14 retinol dehydrogenase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11162 Q9HBH5 203 9.1e-15 Retinol dehydrogenase 14 OS=Homo sapiens GN=RDH14 PE=1 SV=1 PF00106//PF01733 short chain dehydrogenase//Nucleoside transporter GO:0006810//GO:0008152//GO:0015858 transport//metabolic process//nucleoside transport GO:0005337//GO:0016491 nucleoside transmembrane transporter activity//oxidoreductase activity GO:0016021 integral component of membrane KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.31999 BF_2 47.00 1.35 1746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32000 BF_2 76.00 0.87 3926 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32001 BF_2 25.10 0.59 2064 546677893 ERL88643.1 988 3.6e-104 hypothetical protein D910_06027 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P37709 169 1.4e-10 Trichohyalin OS=Oryctolagus cuniculus GN=TCHH PE=2 SV=1 PF01983 Guanylyl transferase CofC like -- -- GO:0016779 nucleotidyltransferase activity -- -- -- -- Cluster-8309.32002 BF_2 91.23 1.56 2729 642934848 XP_008197836.1 1564 7.8e-171 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 239 1.4e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32005 BF_2 154.00 4.09 1861 642917912 XP_008191379.1 813 6.4e-84 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GLD9 394 1.0e-36 UDP-glucuronosyltransferase 2B33 OS=Macaca mulatta GN=UGT2B33 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.32007 BF_2 532.81 14.84 1789 332374316 AEE62299.1 1062 8.3e-113 unknown [Dendroctonus ponderosae]>gi|478255157|gb|ENN75386.1| hypothetical protein YQE_07938, partial [Dendroctonus ponderosae]>gi|546677194|gb|ERL88076.1| hypothetical protein D910_05465 [Dendroctonus ponderosae] 820849703 XM_003694070.2 155 5.51081e-73 PREDICTED: Apis florea cytochrome c-type heme lyase (LOC100866108), mRNA K01764 E4.4.1.17 cytochrome c heme-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01764 Q5F339 774 8.5e-81 Cytochrome c-type heme lyase OS=Gallus gallus GN=HCCS PE=2 SV=1 PF01265 Cytochrome c/c1 heme lyase GO:0015994 chlorophyll metabolic process GO:0004408 holocytochrome-c synthase activity GO:0005739 mitochondrion KOG3996 Holocytochrome c synthase/heme-lyase Cluster-8309.32008 BF_2 644.00 13.94 2220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32009 BF_2 1159.73 11.59 4473 189235133 XP_966882.2 3252 0.0e+00 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.5e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF05366//PF00307 Sarcolipin//Calponin homology (CH) domain -- -- GO:0005515//GO:0030234 protein binding//enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.32011 BF_2 60.70 0.97 2907 642934675 XP_008197763.1 2080 1.2e-230 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 556762122 XM_005976302.1 125 4.28539e-56 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1448 9.7e-159 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556 cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.32013 BF_2 4.89 0.59 635 642937495 XP_008198863.1 180 5.5e-11 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32014 BF_2 411.00 8.97 2203 642921888 XP_008192930.1 829 1.1e-85 PREDICTED: exosome component 10 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 367 1.6e-33 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF00570 HRDC domain -- -- GO:0003676 nucleic acid binding GO:0005622 intracellular KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.32016 BF_2 685.81 12.71 2544 390198530 AFL70632.1 2664 2.0e-298 putative hypoxia-inducible factor 1 beta [Callosobruchus maculatus] 820805517 KP147913.1 529 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1818 1.1e-201 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF00989//PF00010//PF08447 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.32017 BF_2 96.87 2.15 2175 91090182 XP_966481.1 1041 2.8e-110 PREDICTED: methenyltetrahydrofolate synthase domain-containing protein [Tribolium castaneum]>gi|270013764|gb|EFA10212.1| hypothetical protein TcasGA2_TC012407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M296 578 5.5e-58 Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens GN=MTHFSD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4410 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.32018 BF_2 449.00 4.56 4409 270014232 EFA10680.1 1855 2.3e-204 hypothetical protein TcasGA2_TC011653 [Tribolium castaneum] 642936472 XM_008200228.1 150 8.26635e-70 PREDICTED: Tribolium castaneum lysyl oxidase homolog 3 (LOC656295), mRNA K00280 LOXL2_3_4 lysyl oxidase-like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00280 Q9Z175 939 1.5e-99 Lysyl oxidase homolog 3 OS=Mus musculus GN=Loxl3 PE=2 SV=2 PF00111//PF01186//PF15494//PF00530 2Fe-2S iron-sulfur cluster binding domain//Lysyl oxidase//Scavenger receptor cysteine-rich domain//Scavenger receptor cysteine-rich domain GO:0055114//GO:0006118//GO:0007165 oxidation-reduction process//obsolete electron transport//signal transduction GO:0009055//GO:0051536//GO:0016641//GO:0005044//GO:0005507 electron carrier activity//iron-sulfur cluster binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//scavenger receptor activity//copper ion binding GO:0016020 membrane -- -- Cluster-8309.32019 BF_2 548.86 6.90 3616 642925776 XP_008201712.1 2315 8.5e-258 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 9.1e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.32021 BF_2 383.69 4.64 3745 642910971 XP_008193488.1 686 6.9e-69 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O75410 289 3.1e-24 Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens GN=TACC1 PE=1 SV=2 PF07224//PF08702//PF12740 Chlorophyllase//Fibrinogen alpha/beta chain family//Chlorophyllase enzyme GO:0030168//GO:0051258//GO:0015994//GO:0015996//GO:0007165 platelet activation//protein polymerization//chlorophyll metabolic process//chlorophyll catabolic process//signal transduction GO:0005102//GO:0030674//GO:0047746 receptor binding//protein binding, bridging//chlorophyllase activity GO:0005577 fibrinogen complex -- -- Cluster-8309.32022 BF_2 20.85 0.48 2092 546685583 ERL95070.1 2353 1.9e-262 hypothetical protein D910_12340 [Dendroctonus ponderosae] 766942063 XM_011505379.1 266 1.27603e-134 PREDICTED: Ceratosolen solmsi marchali ubiquitin-like modifier-activating enzyme 1 (LOC105366815), mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 A3KMV5 1955 1.1e-217 Ubiquitin-like modifier-activating enzyme 1 OS=Bos taurus GN=UBA1 PE=2 SV=1 PF00899//PF02170//PF09162 ThiF family//PAZ domain//Tap, RNA-binding GO:0006406 mRNA export from nucleus GO:0008641//GO:0005515//GO:0003723 small protein activating enzyme activity//protein binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.32024 BF_2 477.00 19.66 1302 332373766 AEE62024.1 978 3.3e-103 unknown [Dendroctonus ponderosae]>gi|546680371|gb|ERL90650.1| hypothetical protein D910_07997 [Dendroctonus ponderosae] -- -- -- -- -- K08964 mtnB methylthioribulose-1-phosphate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K08964 Q6NU29 827 4.4e-87 Methylthioribulose-1-phosphate dehydratase OS=Xenopus laevis GN=apip PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2631 Class II aldolase/adducin N-terminal domain protein Cluster-8309.32025 BF_2 335.06 3.23 4620 91077318 XP_974708.1 1200 2.1e-128 PREDICTED: mitochondrial folate transporter/carrier [Tribolium castaneum]>gi|270002089|gb|EEZ98536.1| hypothetical protein TcasGA2_TC001040 [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q95J75 880 1.1e-92 Mitochondrial folate transporter/carrier OS=Macaca fascicularis GN=SLC25A32 PE=2 SV=1 PF01150//PF04194 GDA1/CD39 (nucleoside phosphatase) family//Programmed cell death protein 2, C-terminal putative domain GO:0055085 transmembrane transport GO:0016787 hydrolase activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG0764 Mitochondrial FAD carrier protein Cluster-8309.32026 BF_2 601.82 6.82 3978 546680604 ERL90847.1 1793 3.2e-197 hypothetical protein D910_08192 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0WC46 526 1.1e-51 Facilitated trehalose transporter Tret1 OS=Culex quinquefasciatus GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.32028 BF_2 377.69 3.51 4790 332374190 AEE62236.1 1087 2.8e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02967 RP-S2, MRPS2, rpsB small subunit ribosomal protein S2 http://www.genome.jp/dbget-bin/www_bget?ko:K02967 Q9Y399 684 6.2e-70 28S ribosomal protein S2, mitochondrial OS=Homo sapiens GN=MRPS2 PE=1 SV=1 PF00318//PF02558//PF01370//PF00106 Ribosomal protein S2//Ketopantoate reductase PanE/ApbA//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0042254//GO:0055114//GO:0015940//GO:0008152//GO:0006412 ribosome biogenesis//oxidation-reduction process//pantothenate biosynthetic process//metabolic process//translation GO:0008677//GO:0003735//GO:0003824//GO:0050662//GO:0016491 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//catalytic activity//coenzyme binding//oxidoreductase activity GO:0005622//GO:0005840 intracellular//ribosome KOG1205 Predicted dehydrogenase Cluster-8309.32029 BF_2 48.16 0.36 5949 546679118 ERL89623.1 1554 2.5e-169 hypothetical protein D910_06988 [Dendroctonus ponderosae] 195146567 XM_002014220.1 154 6.67966e-72 Drosophila persimilis gpdh (Dper\Gpdh), mRNA K00006 GPD1 glycerol-3-phosphate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00006 O97463 1388 1.8e-151 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Drosophila kanekoi GN=Gpdh1 PE=3 SV=3 PF03798//PF07479//PF01210//PF02258 TLC domain//NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Shiga-like toxin beta subunit GO:0005975//GO:0046486//GO:0055114//GO:0019836//GO:0046168//GO:0006072 carbohydrate metabolic process//glycerolipid metabolic process//oxidation-reduction process//hemolysis by symbiont of host erythrocytes//glycerol-3-phosphate catabolic process//glycerol-3-phosphate metabolic process GO:0004367//GO:0051287//GO:0016616 glycerol-3-phosphate dehydrogenase [NAD+] activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0009331//GO:0005576//GO:0016021 glycerol-3-phosphate dehydrogenase complex//extracellular region//integral component of membrane KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase Cluster-8309.32030 BF_2 37.87 0.79 2288 642931433 XP_008196581.1 268 1.2e-20 PREDICTED: uncharacterized protein LOC662685 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00036//PF13833//PF05497 EF hand//EF-hand domain pair//Destabilase GO:0005975 carbohydrate metabolic process GO:0003796//GO:0005509 lysozyme activity//calcium ion binding -- -- -- -- Cluster-8309.32031 BF_2 169.00 3.00 2644 478252395 ENN72821.1 871 1.7e-90 hypothetical protein YQE_10624, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWD4 350 1.8e-31 Probable RNA-binding protein CG14230 OS=Drosophila melanogaster GN=CG14230 PE=1 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.32032 BF_2 79.00 4.87 966 642921958 XP_008192961.1 701 3.2e-71 PREDICTED: histone deacetylase complex subunit SAP130 [Tribolium castaneum]>gi|642921960|ref|XP_008192962.1| PREDICTED: histone deacetylase complex subunit SAP130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32035 BF_2 90.15 1.06 3829 642922280 XP_008193091.1 2505 8.4e-280 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.7e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.32038 BF_2 68.01 0.90 3443 307173098 EFN64217.1 811 2.0e-83 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 428 2.2e-40 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF04977//PF05485//PF13851//PF00619 Septum formation initiator//THAP domain//Growth-arrest specific micro-tubule binding//Caspase recruitment domain GO:0007049//GO:0042981//GO:0048870 cell cycle//regulation of apoptotic process//cell motility GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.32039 BF_2 2582.45 25.09 4593 307173098 EFN64217.1 1138 3.3e-121 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 568 1.7e-56 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF05485//PF04977//PF13851 THAP domain//Septum formation initiator//Growth-arrest specific micro-tubule binding GO:0048870//GO:0007049 cell motility//cell cycle GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.32040 BF_2 17.00 3.88 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32043 BF_2 94.00 3.38 1451 347962987 XP_311155.4 166 5.3e-09 AGAP000005-PA [Anopheles gambiae str. PEST]>gi|333467412|gb|EAA06432.5| AGAP000005-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03153 Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.32045 BF_2 873.81 8.14 4777 642919809 XP_008192077.1 4749 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X2 [Tribolium castaneum] 642919808 XM_008193855.1 775 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X2, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1894 3.1e-210 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF07714//PF00069//PF06293//PF05445 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.32046 BF_2 223.44 2.24 4456 642919813 XP_008192079.1 4516 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Tribolium castaneum] 642919812 XM_008193857.1 725 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X4, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1839 6.8e-204 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF07714//PF00069//PF06293//PF05445 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.32049 BF_2 277.10 2.69 4598 607362259 EZA56517.1 336 3.3e-28 hypothetical protein X777_03552 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32050 BF_2 122.67 3.20 1892 91079236 XP_970901.1 1361 1.9e-147 PREDICTED: tubulin-specific chaperone E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KS0 795 3.3e-83 Tubulin-specific chaperone E OS=Bos taurus GN=TBCE PE=2 SV=1 PF00564//PF13855 PB1 domain//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.32051 BF_2 5440.80 364.84 911 332375248 AEE62765.1 1172 7.4e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q5ZK84 896 3.1e-95 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.32055 BF_2 754.48 12.23 2867 642914025 XP_968806.3 3744 0.0e+00 PREDICTED: cullin-5 [Tribolium castaneum] 642914024 XM_963713.3 763 0 PREDICTED: Tribolium castaneum cullin-5 (LOC657244), mRNA K10612 CUL5 cullin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10612 Q93034 2839 0.0e+00 Cullin-5 OS=Homo sapiens GN=CUL5 PE=1 SV=4 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.32056 BF_2 23.00 3.80 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32057 BF_2 130.00 5.39 1296 443732396 ELU17138.1 187 1.7e-11 hypothetical protein CAPTEDRAFT_92072 [Capitella teleta] -- -- -- -- -- -- -- -- -- O70210 198 3.8e-14 Chondroadherin OS=Rattus norvegicus GN=Chad PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.32058 BF_2 69.31 1.40 2363 91087517 XP_969270.1 1320 1.3e-142 PREDICTED: phosphatidylinositol glycan anchor biosynthesis class U protein [Tribolium castaneum]>gi|270010669|gb|EFA07117.1| hypothetical protein TcasGA2_TC010108 [Tribolium castaneum] -- -- -- -- -- K05293 PIGU phosphatidylinositol glycan, class U http://www.genome.jp/dbget-bin/www_bget?ko:K05293 Q9H490 702 2.5e-72 Phosphatidylinositol glycan anchor biosynthesis class U protein OS=Homo sapiens GN=PIGU PE=1 SV=3 PF06728 GPI transamidase subunit PIG-U GO:0006506 GPI anchor biosynthetic process -- -- GO:0044425//GO:0016021 membrane part//integral component of membrane KOG2552 Major facilitator superfamily permease - Cdc91p Cluster-8309.32060 BF_2 330.26 17.74 1066 546684932 ERL94514.1 976 4.6e-103 hypothetical protein D910_11791 [Dendroctonus ponderosae] -- -- -- -- -- K02884 RP-L19, MRPL19, rplS large subunit ribosomal protein L19 http://www.genome.jp/dbget-bin/www_bget?ko:K02884 Q9VHN6 822 1.4e-86 39S ribosomal protein L19, mitochondrial OS=Drosophila melanogaster GN=mRpL19 PE=2 SV=1 PF01245 Ribosomal protein L19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1698 Mitochondrial/chloroplast ribosomal protein L19 Cluster-8309.32061 BF_2 1990.62 38.66 2441 91088839 XP_970745.1 1385 4.0e-150 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] 642932363 XM_965652.3 445 0 PREDICTED: Tribolium castaneum RNA-binding protein lark (LOC659335), mRNA K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 914 6.8e-97 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF08777//PF16367//PF00076//PF00098 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc knuckle -- -- GO:0043169//GO:0003676//GO:1901363//GO:0008270//GO:0003723//GO:0097159 cation binding//nucleic acid binding//heterocyclic compound binding//zinc ion binding//RNA binding//organic cyclic compound binding -- -- KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-8309.32063 BF_2 1023.16 11.38 4049 642920320 XP_008192298.1 2616 1.2e-292 PREDICTED: uncharacterized protein LOC664527 isoform X2 [Tribolium castaneum]>gi|270005259|gb|EFA01707.1| hypothetical protein TcasGA2_TC007283 [Tribolium castaneum] 642920319 XM_008194076.1 157 9.74372e-74 PREDICTED: Tribolium castaneum uncharacterized LOC664527 (LOC664527), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00646//PF01429//PF12937//PF00130 F-box domain//Methyl-CpG binding domain//F-box-like//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.32064 BF_2 16.94 0.70 1304 642922198 XP_008193058.1 965 1.1e-101 PREDICTED: patronin isoform X5 [Tribolium castaneum] -- -- -- -- -- K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 656 3.0e-67 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex KOG3654 Uncharacterized CH domain protein Cluster-8309.32066 BF_2 521.27 13.18 1942 189237080 XP_969040.2 1869 2.4e-206 PREDICTED: E3 ubiquitin-protein ligase parkin [Tribolium castaneum] -- -- -- -- -- K04556 PARK2 parkin http://www.genome.jp/dbget-bin/www_bget?ko:K04556 Q9JK66 1007 8.8e-108 E3 ubiquitin-protein ligase parkin OS=Rattus norvegicus GN=Park2 PE=1 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0006 E3 ubiquitin-protein ligase (Parkin protein) Cluster-8309.32067 BF_2 1026.91 12.80 3644 297139749 NP_001171929.1 2729 8.5e-306 LMBR1 domain-containing protein 2 homolog [Tribolium castaneum]>gi|270013548|gb|EFA09996.1| hypothetical protein TcasGA2_TC012164 [Tribolium castaneum] 815824957 XM_012378416.1 68 2.61426e-24 PREDICTED: Linepithema humile LMBR1 domain-containing protein 2 homolog (LOC105678779), mRNA -- -- -- -- Q8MRQ4 1775 1.5e-196 LMBR1 domain-containing protein 2 homolog OS=Drosophila melanogaster GN=CG8135 PE=2 SV=2 PF14777//PF01852 Cilia BBSome complex subunit 10//START domain GO:0042384 cilium assembly GO:0008289 lipid binding GO:0016021//GO:0034464 integral component of membrane//BBSome KOG2296 Integral membrane protein Cluster-8309.32068 BF_2 2214.00 42.84 2449 270006421 EFA02869.1 1344 2.3e-145 serpin peptidase inhibitor 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2I7M9 309 9.7e-27 Serpin A3-2 OS=Bos taurus GN=SERPINA3-2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32069 BF_2 188.00 174.17 323 546686467 ERL95704.1 334 3.9e-29 hypothetical protein D910_00138, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 270 4.2e-23 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32070 BF_2 244.00 6.36 1891 91084843 XP_966905.1 779 5.7e-80 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 501 4.1e-49 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01118 Male sterility protein//Semialdehyde dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0080019//GO:0016620//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- -- -- Cluster-8309.32071 BF_2 10.00 0.35 1491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32072 BF_2 979.15 58.20 991 644997795 XP_008212002.1 655 7.2e-66 PREDICTED: putative fatty acyl-CoA reductase CG5065 isoform X1 [Nasonia vitripennis] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 400 1.1e-37 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.32073 BF_2 145.33 1.99 3348 270001532 EEZ97979.1 2452 1.0e-273 hypothetical protein TcasGA2_TC000374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61627 319 9.2e-28 Glutamate receptor ionotropic, delta-1 OS=Mus musculus GN=Grid1 PE=1 SV=2 PF07826//PF10613//PF00060 IMP cyclohydrolase-like protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006807//GO:0006811//GO:0007165//GO:0006188//GO:0006144//GO:0007268//GO:0006164 nitrogen compound metabolic process//ion transport//signal transduction//IMP biosynthetic process//purine nucleobase metabolic process//synaptic transmission//purine nucleotide biosynthetic process GO:0003937//GO:0005234//GO:0004970 IMP cyclohydrolase activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0042720//GO:0016020 mitochondrial inner membrane peptidase complex//membrane -- -- Cluster-8309.32074 BF_2 1273.00 91.84 867 91085133 XP_969714.1 636 1.0e-63 PREDICTED: probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 [Tribolium castaneum]>gi|270009297|gb|EFA05745.1| hypothetical protein TcasGA2_TC015691 [Tribolium castaneum] 815819816 XM_012375678.1 42 1.71522e-10 PREDICTED: Linepithema humile probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (LOC105677223), transcript variant X2, mRNA K11352 NDUFA12 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11352 Q9N2W7 347 1.3e-31 Probable NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 OS=Caenorhabditis elegans GN=Y94H6A.8 PE=3 SV=2 PF05071//PF00387 NADH ubiquinone oxidoreductase subunit NDUFA12//Phosphatidylinositol-specific phospholipase C, Y domain GO:0006629//GO:0007165//GO:0046339//GO:0006120//GO:0009395//GO:0015992//GO:0035556//GO:0006118//GO:0006814//GO:0006744 lipid metabolic process//signal transduction//diacylglycerol metabolic process//mitochondrial electron transport, NADH to ubiquinone//phospholipid catabolic process//proton transport//intracellular signal transduction//obsolete electron transport//sodium ion transport//ubiquinone biosynthetic process GO:0004435//GO:0008137//GO:0009055 phosphatidylinositol phospholipase C activity//NADH dehydrogenase (ubiquinone) activity//electron carrier activity GO:0016020 membrane KOG3382 NADH:ubiquinone oxidoreductase, B17.2 subunit Cluster-8309.32075 BF_2 1833.15 14.80 5468 642913773 XP_008201155.1 5985 0.0e+00 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6H8H2 2020 8.6e-225 DENN domain-containing protein 4C OS=Mus musculus GN=Dennd4c PE=1 SV=1 PF02055//PF02861 O-Glycosyl hydrolase family 30//Clp amino terminal domain, pathogenicity island component GO:0006687//GO:0019538//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//protein metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity -- -- KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.32077 BF_2 24.71 1.01 1314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32078 BF_2 2750.19 48.48 2660 728418853 AIY68384.1 1994 1.0e-220 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 678 1.7e-69 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.32079 BF_2 348.15 6.07 2687 642913197 XP_008201432.1 1434 9.1e-156 PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913199|ref|XP_008201433.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913201|ref|XP_008201434.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 790 1.8e-82 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 PF00207 Alpha-2-macroglobulin family -- -- GO:0004866 endopeptidase inhibitor activity -- -- KOG1212 Amidases Cluster-8309.3208 BF_2 7.00 1.26 519 859746458 XP_004737878.2 755 9.5e-78 PREDICTED: 40S ribosomal protein S14 [Mustela putorius furo] 675791485 XM_003829021.2 519 0 PREDICTED: Pan paniscus ribosomal protein S14 (RPS14), transcript variant X1, mRNA >gnl|BL_ORD_ID|21104180 PREDICTED: Pan troglodytes ribosomal protein S14 (RPS14), mRNA K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P62263 710 6.5e-74 40S ribosomal protein S14 OS=Homo sapiens GN=RPS14 PE=1 SV=3 PF03423//PF00411 Carbohydrate binding domain (family 25)//Ribosomal protein S11 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.32080 BF_2 72.79 0.86 3848 728418853 AIY68384.1 614 1.6e-60 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35501 301 1.3e-25 Esterase E4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32081 BF_2 47.00 5.60 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32082 BF_2 586.79 8.52 3167 91087321 XP_975587.1 918 7.3e-96 PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|642929809|ref|XP_008195985.1| PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|270009526|gb|EFA05974.1| hypothetical protein TcasGA2_TC008799 [Tribolium castaneum] 186969251 EU616728.1 55 3.82319e-17 Kryptolebias marmoratus R-ras3 mRNA, complete cds K07830 RRAS2, TC21 Ras-related protein R-Ras2 http://www.genome.jp/dbget-bin/www_bget?ko:K07830 P04388 727 4.2e-75 Ras-like protein 2 OS=Drosophila melanogaster GN=Ras64B PE=1 SV=2 PF08477//PF01926//PF02421//PF00025//PF03193//PF08469//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ferrous iron transport protein B//ADP-ribosylation factor family//Protein of unknown function, DUF258//Nucleoside triphosphatase I C-terminal//Gtr1/RagA G protein conserved region//Ras family GO:0006351//GO:0015684//GO:0007264//GO:0006184 transcription, DNA-templated//ferrous iron transport//small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005524//GO:0015093//GO:0017111//GO:0005525 GTPase activity//ATP binding//ferrous iron transmembrane transporter activity//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0395 Ras-related GTPase Cluster-8309.32083 BF_2 115.32 1.80 2962 91087321 XP_975587.1 825 4.2e-85 PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|642929809|ref|XP_008195985.1| PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|270009526|gb|EFA05974.1| hypothetical protein TcasGA2_TC008799 [Tribolium castaneum] 186969251 EU616728.1 55 3.57287e-17 Kryptolebias marmoratus R-ras3 mRNA, complete cds K07830 RRAS2, TC21 Ras-related protein R-Ras2 http://www.genome.jp/dbget-bin/www_bget?ko:K07830 P04388 659 3.0e-67 Ras-like protein 2 OS=Drosophila melanogaster GN=Ras64B PE=1 SV=2 PF08477//PF00071//PF00025//PF08469 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family//Nucleoside triphosphatase I C-terminal GO:0007264//GO:0006184//GO:0006351 small GTPase mediated signal transduction//obsolete GTP catabolic process//transcription, DNA-templated GO:0017111//GO:0005525//GO:0003924//GO:0005524 nucleoside-triphosphatase activity//GTP binding//GTPase activity//ATP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.32084 BF_2 550.74 4.48 5424 91092978 XP_967458.1 1021 1.4e-107 PREDICTED: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [Tribolium castaneum]>gi|270004800|gb|EFA01248.1| hypothetical protein TcasGA2_TC002125 [Tribolium castaneum] 827558552 XM_012694950.1 58 1.4141e-18 PREDICTED: Bombyx mori TPPP family protein CG45057-like (LOC101741645), transcript variant X2, mRNA K13084 TMEM55 phosphatidylinositol-4,5-bisphosphate 4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13084 Q4R6W2 542 2.1e-53 Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Macaca fascicularis GN=TMEM55B PE=2 SV=1 PF13903//PF02892//PF09788 PMP-22/EMP/MP20/Claudin tight junction//BED zinc finger//Transmembrane protein 55A GO:0046856 phosphatidylinositol dephosphorylation GO:0034597//GO:0003677 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//DNA binding GO:0016021 integral component of membrane KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger Cluster-8309.32086 BF_2 41.00 7.80 507 270007709 EFA04157.1 494 1.7e-47 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 365 6.4e-34 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF02456//PF13304//PF01926//PF00005//PF00735//PF03193//PF00931 Adenovirus IVa2 protein//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Septin//Protein of unknown function, DUF258//NB-ARC domain GO:0019083 viral transcription GO:0016887//GO:0005525//GO:0005524//GO:0003924//GO:0043531 ATPase activity//GTP binding//ATP binding//GTPase activity//ADP binding -- -- -- -- Cluster-8309.32088 BF_2 26.07 2.19 786 835482914 AKM70276.1 143 1.3e-06 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06974 Protein of unknown function (DUF1298) GO:0042967//GO:0046486 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.32089 BF_2 10.00 6.63 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32090 BF_2 9.00 10.73 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32091 BF_2 110.27 0.48 9809 270017072 EFA13518.1 1224 7.5e-131 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1016 4.0e-108 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF00098//PF09207 Integrase core domain//Zinc knuckle//Yeast killer toxin GO:0015074//GO:0008219//GO:0009405 DNA integration//cell death//pathogenesis GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.32094 BF_2 36.29 0.36 4526 91078836 XP_971451.1 1852 5.2e-204 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 2.39347e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1521 5.2e-167 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0005975//GO:0006508//GO:0008152 carbohydrate metabolic process//proteolysis//metabolic process GO:0016805//GO:0008237//GO:0034701//GO:0016787//GO:0004560 dipeptidase activity//metallopeptidase activity//tripeptidase activity//hydrolase activity//alpha-L-fucosidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.32095 BF_2 40.94 0.46 4015 91078836 XP_971451.1 1831 1.3e-201 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 2.12107e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1501 9.5e-165 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01120//PF01546 Alpha-L-fucosidase//Peptidase family M20/M25/M40 GO:0006508//GO:0005975//GO:0008152 proteolysis//carbohydrate metabolic process//metabolic process GO:0008237//GO:0016805//GO:0016787//GO:0004560//GO:0034701 metallopeptidase activity//dipeptidase activity//hydrolase activity//alpha-L-fucosidase activity//tripeptidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.32096 BF_2 31.53 0.34 4143 557876145 AHA39267.1 247 6.1e-18 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395//PF02522//PF02391 PBP/GOBP family//Aminoglycoside 3-N-acetyltransferase//MoaE protein GO:0046677//GO:0006777//GO:0042967 response to antibiotic//Mo-molybdopterin cofactor biosynthetic process//acyl-carrier-protein biosynthetic process GO:0046353//GO:0005549 aminoglycoside 3-N-acetyltransferase activity//odorant binding -- -- -- -- Cluster-8309.32097 BF_2 45.35 0.68 3087 642934677 XP_008197764.1 2325 5.0e-259 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X3 [Tribolium castaneum] 556762122 XM_005976302.1 125 4.55407e-56 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1565 2.8e-172 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.32098 BF_2 806.35 9.58 3808 642934673 XP_008197762.1 915 2.0e-95 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X1 [Tribolium castaneum] 642934684 XM_008199547.1 208 4.08398e-102 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 220 3.1e-16 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF03594 Benzoate membrane transport protein GO:0042919//GO:0006810 benzoate transport//transport GO:0042925 benzoate transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.32099 BF_2 164.45 0.98 7327 642934675 XP_008197763.1 4436 0.0e+00 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 642934684 XM_008199547.1 110 2.37139e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1584 4.1e-174 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0016114 cyclic nucleotide biosynthetic process//intracellular signal transduction//terpenoid biosynthetic process GO:0016849//GO:0008685 phosphorus-oxygen lyase activity//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity -- -- -- -- Cluster-8309.3210 BF_2 42.00 0.76 2596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32104 BF_2 854.00 18.82 2185 91076782 XP_967792.1 2163 2.2e-240 PREDICTED: sphingosine-1-phosphate lyase [Tribolium castaneum]>gi|270001960|gb|EEZ98407.1| hypothetical protein TcasGA2_TC000875 [Tribolium castaneum] -- -- -- -- -- K01634 SGPL1, DPL1 sphinganine-1-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01634 Q9V7Y2 1803 5.0e-200 Sphingosine-1-phosphate lyase OS=Drosophila melanogaster GN=Sply PE=2 SV=1 PF01053//PF01212//PF00282//PF00155//PF05889//PF04099//PF07497 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Pyridoxal-dependent decarboxylase conserved domain//Aminotransferase class I and II//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Sybindin-like family//Rho termination factor, RNA-binding domain GO:0019752//GO:0006888//GO:0006520//GO:0009058//GO:0006353 carboxylic acid metabolic process//ER to Golgi vesicle-mediated transport//cellular amino acid metabolic process//biosynthetic process//DNA-templated transcription, termination GO:0030170//GO:0003723//GO:0016831//GO:0016740//GO:0016829 pyridoxal phosphate binding//RNA binding//carboxy-lyase activity//transferase activity//lyase activity GO:0005801 cis-Golgi network KOG1383 Glutamate decarboxylase/sphingosine phosphate lyase Cluster-8309.32105 BF_2 1440.61 169.35 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32107 BF_2 391.43 4.92 3613 380024529 XP_003696047.1 1619 4.3e-177 PREDICTED: glycerol-3-phosphate acyltransferase 4 isoform X1 [Apis florea] 545878863 XM_005672663.1 101 1.1722e-42 PREDICTED: Sus scrofa 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (AGPAT6), transcript variant X2, mRNA K13506 GPAT3_4, AGPAT9, AGPAT6 glycerol-3-phosphate O-acyltransferase 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13506 A3KGT9 943 4.3e-100 Glycerol-3-phosphate acyltransferase 3-like OS=Danio rerio GN=agpat9l PE=3 SV=1 PF01553//PF02812//PF00481 Acyltransferase//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain//Protein phosphatase 2C GO:0008152//GO:0055114//GO:0006520 metabolic process//oxidation-reduction process//cellular amino acid metabolic process GO:0003824//GO:0016746//GO:0016491 catalytic activity//transferase activity, transferring acyl groups//oxidoreductase activity -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.32108 BF_2 1661.37 22.43 3385 642912309 XP_008200644.1 1969 1.1e-217 PREDICTED: glycerol-3-phosphate acyltransferase 4 isoform X2 [Tribolium castaneum] 545878863 XM_005672663.1 113 2.34226e-49 PREDICTED: Sus scrofa 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (AGPAT6), transcript variant X2, mRNA K13506 GPAT3_4, AGPAT9, AGPAT6 glycerol-3-phosphate O-acyltransferase 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13506 Q8K2C8 1146 1.2e-123 Glycerol-3-phosphate acyltransferase 4 OS=Mus musculus GN=Agpat6 PE=2 SV=1 PF01553//PF00481 Acyltransferase//Protein phosphatase 2C GO:0008152 metabolic process GO:0003824//GO:0016746 catalytic activity//transferase activity, transferring acyl groups -- -- KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.32110 BF_2 12.46 0.35 1778 642915553 XP_008190664.1 1295 7.9e-140 PREDICTED: RNA-binding protein 25 isoform X3 [Tribolium castaneum] 564267634 XM_006272560.1 54 7.65727e-17 PREDICTED: Alligator mississippiensis RNA binding motif protein 25 (RBM25), mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 1.4e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.32111 BF_2 645.71 4.00 7036 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 4.89351e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.6e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13895//PF13855//PF03526//PF00560 Immunoglobulin domain//Leucine rich repeat//Colicin E1 (microcin) immunity protein//Leucine Rich Repeat GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.32112 BF_2 68.98 0.84 3715 642915551 XP_008190663.1 1295 1.7e-139 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 71 5.72957e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 2.9e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.32114 BF_2 42.33 0.34 5519 642930620 XP_008199196.1 655 4.0e-65 PREDICTED: protein winged eye isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3LHL9 463 3.0e-44 Protein winged eye OS=Drosophila melanogaster GN=wge PE=1 SV=1 PF01426//PF05297//PF13181 BAH domain//Herpesvirus latent membrane protein 1 (LMP1)//Tetratricopeptide repeat GO:0019087 transformation of host cell by virus GO:0003682//GO:0005515 chromatin binding//protein binding GO:0000785//GO:0016021 chromatin//integral component of membrane -- -- Cluster-8309.32115 BF_2 527.00 9.53 2601 642923875 XP_966553.2 1626 4.8e-178 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC654991 [Tribolium castaneum] -- -- -- -- -- K06129 LYPLA3 lysophospholipase III http://www.genome.jp/dbget-bin/www_bget?ko:K06129 Q8NCC3 1002 4.5e-107 Group XV phospholipase A2 OS=Homo sapiens GN=PLA2G15 PE=1 SV=2 PF01674//PF02450//PF07819 Lipase (class 2)//Lecithin:cholesterol acyltransferase//PGAP1-like protein GO:0042967//GO:0006886//GO:0006629//GO:0006505 acyl-carrier-protein biosynthetic process//intracellular protein transport//lipid metabolic process//GPI anchor metabolic process GO:0008374//GO:0016787//GO:0016788 O-acyltransferase activity//hydrolase activity//hydrolase activity, acting on ester bonds -- -- KOG2369 Lecithin:cholesterol acyltransferase (LCAT)/Acyl-ceramide synthase Cluster-8309.32117 BF_2 552.65 14.81 1848 546685827 ERL95270.1 1821 8.4e-201 hypothetical protein D910_12536 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 656 4.2e-67 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32120 BF_2 1188.00 22.09 2537 91076230 XP_972985.1 678 4.0e-68 PREDICTED: synaptoporin [Tribolium castaneum]>gi|642911829|ref|XP_008200762.1| PREDICTED: synaptoporin [Tribolium castaneum]>gi|270014547|gb|EFA10995.1| hypothetical protein TcasGA2_TC004580 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5YJC1 397 6.3e-37 Synaptophysin OS=Spermophilus citellus GN=SYP PE=2 SV=1 PF01284//PF00654 Membrane-associating domain//Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane -- -- Cluster-8309.32122 BF_2 833.29 20.58 1981 91085293 XP_968143.1 1388 1.5e-150 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 P52788 700 3.6e-72 Spermine synthase OS=Homo sapiens GN=SMS PE=1 SV=2 PF00891//PF03602//PF05175//PF02390//PF08241 O-methyltransferase//Conserved hypothetical protein 95//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain GO:0006400//GO:0019482//GO:0006597//GO:0008033//GO:0009451//GO:0006560//GO:0031167//GO:0006525//GO:0008152 tRNA modification//beta-alanine metabolic process//spermine biosynthetic process//tRNA processing//RNA modification//proline metabolic process//rRNA methylation//arginine metabolic process//metabolic process GO:0008168//GO:0008176//GO:0016768//GO:0008171 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//spermine synthase activity//O-methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.32123 BF_2 48.54 1.16 2042 91085293 XP_968143.1 1224 1.6e-131 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 P52788 627 1.1e-63 Spermine synthase OS=Homo sapiens GN=SMS PE=1 SV=2 PF08241//PF01728//PF02390//PF05175//PF03602//PF00891 Methyltransferase domain//FtsJ-like methyltransferase//Putative methyltransferase//Methyltransferase small domain//Conserved hypothetical protein 95//O-methyltransferase GO:0006525//GO:0008152//GO:0031167//GO:0006560//GO:0009451//GO:0006597//GO:0008033//GO:0019482//GO:0032259//GO:0006400 arginine metabolic process//metabolic process//rRNA methylation//proline metabolic process//RNA modification//spermine biosynthetic process//tRNA processing//beta-alanine metabolic process//methylation//tRNA modification GO:0008171//GO:0016768//GO:0008176//GO:0008168 O-methyltransferase activity//spermine synthase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.32124 BF_2 76.63 1.20 2956 91085293 XP_968143.1 1025 2.7e-108 PREDICTED: spermine synthase [Tribolium castaneum]>gi|270009119|gb|EFA05567.1| hypothetical protein TcasGA2_TC015756 [Tribolium castaneum] -- -- -- -- -- K00802 SMS spermine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00802 P52788 607 3.3e-61 Spermine synthase OS=Homo sapiens GN=SMS PE=1 SV=2 PF00891//PF05175//PF01728//PF02390//PF08241//PF03602 O-methyltransferase//Methyltransferase small domain//FtsJ-like methyltransferase//Putative methyltransferase//Methyltransferase domain//Conserved hypothetical protein 95 GO:0031167//GO:0006560//GO:0008152//GO:0006525//GO:0019482//GO:0032259//GO:0006400//GO:0006597//GO:0008033//GO:0009451 rRNA methylation//proline metabolic process//metabolic process//arginine metabolic process//beta-alanine metabolic process//methylation//tRNA modification//spermine biosynthetic process//tRNA processing//RNA modification GO:0008171//GO:0008168//GO:0016768//GO:0008176 O-methyltransferase activity//methyltransferase activity//spermine synthase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG1562 Spermidine synthase Cluster-8309.32127 BF_2 29.00 0.87 1674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF01777//PF13912//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Ribosomal L27e protein family//C2H2-type zinc finger//BED zinc finger GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0046872//GO:0003735//GO:0003677 metal ion binding//structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.32129 BF_2 45.06 0.71 2951 861626561 KMQ88832.1 811 1.7e-83 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225 DDE superfamily endonuclease//helix-turn-helix, Psq domain -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.32132 BF_2 249.54 1.74 6280 642912787 XP_008201252.1 1303 3.3e-140 PREDICTED: uncharacterized protein LOC663557 isoform X2 [Tribolium castaneum] 795034384 XM_012009201.1 239 3.95334e-119 PREDICTED: Vollenhovia emeryi protein FAM46C (LOC105560258), transcript variant X3, mRNA -- -- -- -- Q7ZUP1 787 9.3e-82 Protein FAM46C OS=Danio rerio GN=fam46c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3852 Uncharacterized conserved protein Cluster-8309.32133 BF_2 9.55 0.90 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32134 BF_2 127.15 1.82 3202 642921094 XP_008192689.1 2519 1.7e-281 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q6GP15 789 2.8e-82 Mediator of RNA polymerase II transcription subunit 25 OS=Xenopus laevis GN=med25 PE=2 SV=1 PF09398//PF00643 FOP N terminal dimerisation domain//B-box zinc finger GO:0034453 microtubule anchoring GO:0008270 zinc ion binding GO:0005815//GO:0005622 microtubule organizing center//intracellular -- -- Cluster-8309.32136 BF_2 2622.54 14.92 7642 642916293 XP_008190963.1 10096 0.0e+00 PREDICTED: CCR4-NOT transcription complex subunit 1 isoform X1 [Tribolium castaneum]>gi|270004176|gb|EFA00624.1| hypothetical protein TcasGA2_TC003500 [Tribolium castaneum] 642916292 XM_008192741.1 1474 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 1 (LOC663739), transcript variant X1, mRNA K12604 CNOT1, NOT1 CCR4-NOT transcription complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12604 Q6ZQ08 6499 0.0e+00 CCR4-NOT transcription complex subunit 1 OS=Mus musculus GN=Cnot1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1831 Negative regulator of transcription Cluster-8309.32137 BF_2 62.22 2.73 1240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02346 Chordopoxvirus multifunctional envelope protein A27 GO:0019064 fusion of virus membrane with host plasma membrane -- -- GO:0019031 viral envelope -- -- Cluster-8309.32138 BF_2 88.83 7.33 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03419 Sporulation factor SpoIIGA GO:0030436//GO:0006508 asexual sporulation//proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.32139 BF_2 14.00 2.75 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32140 BF_2 42.00 121.11 271 291170322 ADD82417.1 305 7.5e-26 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 135 9.81689e-63 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32141 BF_2 6681.50 832.18 623 91078856 XP_972007.1 532 8.3e-52 PREDICTED: 60S ribosomal protein L36 [Tribolium castaneum]>gi|270003715|gb|EFA00163.1| hypothetical protein TcasGA2_TC002985 [Tribolium castaneum] -- -- -- -- -- K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 P49630 426 6.6e-41 60S ribosomal protein L36 OS=Drosophila melanogaster GN=RpL36 PE=1 SV=1 PF01158 Ribosomal protein L36e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3452 60S ribosomal protein L36 Cluster-8309.32142 BF_2 16.93 0.38 2167 642931828 XP_971231.2 1513 5.1e-165 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q8BH70 551 7.4e-55 F-box/LRR-repeat protein 4 OS=Mus musculus GN=Fbxl4 PE=2 SV=1 PF12937//PF13516//PF15966//PF00560//PF00646 F-box-like//Leucine Rich repeat//F-box//Leucine Rich Repeat//F-box domain -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.32144 BF_2 6.07 0.54 755 646703952 KDR12362.1 358 1.5e-31 Superoxide dismutase [Cu-Zn] [Zootermopsis nevadensis] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P41973 326 3.2e-29 Superoxide dismutase [Cu-Zn] OS=Drosophila willistoni GN=Sod PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.32146 BF_2 1478.84 22.18 3076 91078182 XP_967647.1 2377 4.7e-265 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCI6 1013 2.8e-108 Beta-galactosidase-1-like protein 3 OS=Homo sapiens GN=GLB1L3 PE=2 SV=3 PF02449 Beta-galactosidase GO:0006687//GO:0005975//GO:0046486//GO:0006027//GO:0006012 glycosphingolipid metabolic process//carbohydrate metabolic process//glycerolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process GO:0043169//GO:0004565 cation binding//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.32147 BF_2 79.58 1.02 3545 642922441 XP_008193170.1 2357 1.1e-262 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922836 XM_008195125.1 330 5.75796e-170 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X1, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1929 2.0e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF00479//PF02781//PF00180 Glucose-6-phosphate dehydrogenase, NAD binding domain//Glucose-6-phosphate dehydrogenase, C-terminal domain//Isocitrate/isopropylmalate dehydrogenase GO:0006749//GO:0006006//GO:0006098//GO:0055114 glutathione metabolic process//glucose metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0004345//GO:0016616 NADP binding//glucose-6-phosphate dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.32149 BF_2 127.50 1.26 4523 642911078 XP_008200566.1 2414 3.5e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 4.1e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF00076//PF11648//PF01585//PF01080//PF07808//PF00641//PF13442 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C-terminal domain of RIG-I//G-patch domain//Presenilin//RED-like protein N-terminal region//Zn-finger in Ran binding protein and others//Cytochrome C oxidase, cbb3-type, subunit III GO:0006118 obsolete electron transport GO:0004190//GO:0003676//GO:0009055//GO:0008270//GO:0000166//GO:0016817//GO:0020037 aspartic-type endopeptidase activity//nucleic acid binding//electron carrier activity//zinc ion binding//nucleotide binding//hydrolase activity, acting on acid anhydrides//heme binding GO:0005634//GO:0016021//GO:0005622 nucleus//integral component of membrane//intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32150 BF_2 179.57 2.96 2827 642914797 XP_008190357.1 1046 9.4e-111 PREDICTED: poly(rC)-binding protein 3 isoform X1 [Tribolium castaneum]>gi|642914799|ref|XP_008190358.1| PREDICTED: poly(rC)-binding protein 3 isoform X1 [Tribolium castaneum]>gi|642914801|ref|XP_008190359.1| PREDICTED: poly(rC)-binding protein 3 isoform X1 [Tribolium castaneum] 642914800 XM_008192137.1 406 0 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X3, mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57721 738 2.0e-76 Poly(rC)-binding protein 3 OS=Homo sapiens GN=PCBP3 PE=2 SV=2 PF07650//PF06326//PF00013//PF13184//PF13014 KH domain//Vesiculovirus matrix protein//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723//GO:0005198 RNA binding//structural molecule activity GO:0019031 viral envelope KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.32152 BF_2 21.00 8.57 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32153 BF_2 475.00 15.78 1546 189239344 XP_973859.2 1727 5.6e-190 PREDICTED: 28S ribosomal protein S5, mitochondrial [Tribolium castaneum]>gi|270010452|gb|EFA06900.1| hypothetical protein TcasGA2_TC009847 [Tribolium castaneum] -- -- -- -- -- K02988 RP-S5, MRPS5, rpsE small subunit ribosomal protein S5 http://www.genome.jp/dbget-bin/www_bget?ko:K02988 Q2KID9 705 7.4e-73 28S ribosomal protein S5, mitochondrial OS=Bos taurus GN=MRPS5 PE=1 SV=1 PF03719//PF00333 Ribosomal protein S5, C-terminal domain//Ribosomal protein S5, N-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG2646 Ribosomal protein S5 Cluster-8309.32154 BF_2 712.00 13.82 2442 642910741 XP_008193389.1 2229 5.4e-248 PREDICTED: UPF0518 protein AGAP011705 [Tribolium castaneum]>gi|270015022|gb|EFA11470.1| hypothetical protein TcasGA2_TC014180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PZ36 1341 2.1e-146 UPF0518 protein AGAP011705 OS=Anopheles gambiae GN=AGAP011705 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG3695 Uncharacterized conserved protein Cluster-8309.32156 BF_2 29.95 0.67 2155 270014168 EFA10616.1 232 1.8e-16 hypothetical protein TcasGA2_TC012878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32158 BF_2 21.00 0.76 1447 556728350 XP_005959908.1 524 1.6e-50 PREDICTED: zinc finger protein 836-like [Pantholops hodgsonii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 489 7.7e-48 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF13465//PF00096//PF13912//PF02892//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.32159 BF_2 34.59 1.38 1336 642930127 XP_008196262.1 430 1.2e-39 PREDICTED: protein lethal(2)essential for life isoform X1 [Tribolium castaneum] 805772113 XM_003701659.2 53 2.05566e-16 PREDICTED: Megachile rotundata protein lethal(2)essential for life-like (LOC100881460), mRNA K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 348 1.6e-31 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525 Alpha crystallin A chain, N terminal GO:0007423 sensory organ development GO:0005212 structural constituent of eye lens -- -- -- -- Cluster-8309.32160 BF_2 790.43 26.73 1524 642928886 XP_008195603.1 400 4.1e-36 PREDICTED: junctional adhesion molecule B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32161 BF_2 62.03 2.87 1191 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32162 BF_2 47.00 2.95 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32163 BF_2 1537.70 46.89 1659 91091550 XP_971130.1 810 1.3e-83 PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|270000919|gb|EEZ97366.1| hypothetical protein TcasGA2_TC011188 [Tribolium castaneum]>gi|332373990|gb|AEE62136.1| unknown [Dendroctonus ponderosae]>gi|546685461|gb|ERL94965.1| hypothetical protein D910_12237 [Dendroctonus ponderosae] 657798762 XM_008328253.1 115 8.78313e-51 PREDICTED: Cynoglossus semilaevis ubiquitin-conjugating enzyme E2 A (LOC103391826), mRNA K10573 UBE2A, UBC2, RAD6A ubiquitin-conjugating enzyme E2 A http://www.genome.jp/dbget-bin/www_bget?ko:K10573 P25153 791 8.4e-83 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=UbcD6 PE=2 SV=2 PF05773//PF05743 RWD domain//UEV domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005524//GO:0016881//GO:0005515 ATP binding//acid-amino acid ligase activity//protein binding -- -- KOG0419 Ubiquitin-protein ligase Cluster-8309.32166 BF_2 1153.78 75.55 926 91079212 XP_966680.1 897 5.8e-94 PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|642916704|ref|XP_008192258.1| PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|270004989|gb|EFA01437.1| hypothetical protein TcasGA2_TC030667 [Tribolium castaneum] 665815702 XM_008558299.1 225 3.4269e-112 PREDICTED: Microplitis demolitor myosin regulatory light chain sqh (LOC103577593), mRNA K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 P40423 847 1.5e-89 Myosin regulatory light chain sqh OS=Drosophila melanogaster GN=sqh PE=1 SV=1 PF13499//PF13833//PF10591//PF13405//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.32167 BF_2 29.00 16.47 357 91094065 XP_969875.1 240 3.4e-18 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016181|gb|EFA12629.1| cytochrome P450 6BR1 [Tribolium castaneum] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964R1 200 6.1e-15 Cytochrome P450 6j1 OS=Blattella germanica GN=CYP6J1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506//GO:0016491//GO:0046872 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.32168 BF_2 384.18 12.84 1539 73921480 AAZ94270.1 1112 1.1e-118 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 698 4.7e-72 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005488//GO:0016705//GO:0016491//GO:0005506//GO:0020037 binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//iron ion binding//heme binding -- -- -- -- Cluster-8309.32169 BF_2 499.00 24.62 1135 -- -- -- -- -- 642934086 XM_008198387.1 57 1.03994e-18 PREDICTED: Tribolium castaneum phosphatase and actin regulator 1 (LOC656132), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32172 BF_2 1590.53 16.38 4348 91083141 XP_971340.1 615 1.4e-60 PREDICTED: akirin [Tribolium castaneum]>gi|270007685|gb|EFA04133.1| hypothetical protein TcasGA2_TC014377 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS59 340 4.4e-30 Akirin OS=Drosophila melanogaster GN=akirin PE=1 SV=1 PF00056 lactate/malate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG4330 Uncharacterized conserved protein Cluster-8309.32174 BF_2 18.30 0.37 2372 573896974 XP_006636225.1 161 3.3e-08 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O54819 145 9.7e-08 Tissue factor pathway inhibitor OS=Mus musculus GN=Tfpi PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.32175 BF_2 165.00 6.38 1369 642939095 XP_008200219.1 1259 9.1e-136 PREDICTED: AH receptor-interacting protein [Tribolium castaneum]>gi|270016257|gb|EFA12703.1| hypothetical protein TcasGA2_TC002337 [Tribolium castaneum] -- -- -- -- -- K17767 AIP, XAP2 AH receptor-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17767 O00170 685 1.4e-70 AH receptor-interacting protein OS=Homo sapiens GN=AIP PE=1 SV=2 PF13414//PF00254//PF08631//PF00515//PF13181 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0051321//GO:0006457 meiotic cell cycle//protein folding GO:0005515 protein binding -- -- KOG0545 Aryl-hydrocarbon receptor-interacting protein Cluster-8309.32177 BF_2 374.24 8.62 2103 642915809 XP_008200087.1 1148 1.0e-122 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 475 4.7e-46 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.32178 BF_2 633.20 15.73 1971 642937291 XP_008198773.1 2091 4.4e-232 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X2 [Tribolium castaneum]>gi|270000838|gb|EEZ97285.1| hypothetical protein TcasGA2_TC011089 [Tribolium castaneum] 195481875 XM_002101781.1 176 1.28901e-84 Drosophila yakuba GE15405 (Dyak\GE15405), partial mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1700 3.9e-188 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.32179 BF_2 854.00 31.48 1422 478250943 ENN71427.1 497 2.2e-47 hypothetical protein YQE_11846, partial [Dendroctonus ponderosae]>gi|546682689|gb|ERL92601.1| hypothetical protein D910_09914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVA0 347 2.2e-31 Cold shock domain-containing protein CG9705 OS=Drosophila melanogaster GN=CG9705 PE=1 SV=1 PF00313 'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.32180 BF_2 80.55 0.96 3795 642939400 XP_008193248.1 252 1.5e-18 PREDICTED: uncharacterized protein LOC103312106 [Tribolium castaneum]>gi|270016475|gb|EFA12921.1| hypothetical protein TcasGA2_TC006991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32183 BF_2 1415.51 38.03 1844 478258843 ENN78848.1 421 1.8e-38 hypothetical protein YQE_04696, partial [Dendroctonus ponderosae]>gi|546684143|gb|ERL93848.1| hypothetical protein D910_11134 [Dendroctonus ponderosae] -- -- -- -- -- K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P38410 396 5.9e-37 Guanine nucleotide-binding protein G(q) subunit alpha OS=Xenopus laevis GN=gnaq PE=2 SV=2 PF00503 G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0031683//GO:0019001//GO:0004871//GO:0003924 G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32184 BF_2 15.22 0.31 2324 815825480 XP_012234117.1 752 9.5e-77 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X5 [Linepithema humile] 768434415 XM_011560315.1 190 2.51443e-92 PREDICTED: Plutella xylostella guanine nucleotide-binding protein G(q) subunit alpha (LOC105389225), transcript variant X4, mRNA K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P23625 678 1.5e-69 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 PF00503//PF00025 G-protein alpha subunit//ADP-ribosylation factor family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0031683//GO:0019001//GO:0004871//GO:0003924 GTP binding//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32185 BF_2 1629.75 60.40 1416 642913315 XP_008195239.1 1358 3.1e-147 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X1 [Tribolium castaneum] 462426418 APGK01016400.1 327 1.05465e-168 Dendroctonus ponderosae Seq01016410, whole genome shotgun sequence K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P23625 1246 1.2e-135 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 PF01926//PF08477//PF00025//PF04670//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0031683//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32186 BF_2 7.00 0.50 869 815825474 XP_012234113.1 291 1.0e-23 PREDICTED: guanine nucleotide-binding protein G(q) subunit alpha isoform X2 [Linepithema humile] -- -- -- -- -- K04634 GNAQ guanine nucleotide-binding protein G(q) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04634 P50148 278 1.3e-23 Guanine nucleotide-binding protein G(q) subunit alpha OS=Homo sapiens GN=GNAQ PE=1 SV=4 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0019001//GO:0004871//GO:0031683//GO:0003924 guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.32187 BF_2 128.97 0.78 7211 478256710 ENN76892.1 1622 3.9e-177 hypothetical protein YQE_06733, partial [Dendroctonus ponderosae]>gi|546685091|gb|ERL94618.1| hypothetical protein D910_11895 [Dendroctonus ponderosae] 749732005 XM_011139608.1 229 1.64551e-113 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1333 5.2e-145 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF13414//PF06293//PF02434//PF00069//PF07714//PF01762 TPR repeat//Lipopolysaccharide kinase (Kdo/WaaP) family//Fringe-like//Protein kinase domain//Protein tyrosine kinase//Galactosyltransferase GO:0006468//GO:0006486 protein phosphorylation//protein glycosylation GO:0005524//GO:0016757//GO:0005515//GO:0016773//GO:0008378//GO:0004672 ATP binding//transferase activity, transferring glycosyl groups//protein binding//phosphotransferase activity, alcohol group as acceptor//galactosyltransferase activity//protein kinase activity GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.32188 BF_2 14.64 0.43 1697 831573204 XP_012735619.1 786 7.9e-81 PREDICTED: glycogenin-1 isoform X2 [Fundulus heteroclitus] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 Q9R062 740 7.1e-77 Glycogenin-1 OS=Mus musculus GN=Gyg1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.32189 BF_2 114.39 1.32 3903 642928336 XP_008195540.1 2691 2.3e-301 PREDICTED: slit homolog 1 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70193 294 8.5e-25 Leucine-rich repeats and immunoglobulin-like domains protein 1 OS=Mus musculus GN=Lrig1 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32193 BF_2 381.52 7.02 2560 642911289 XP_008199357.1 1942 1.1e-214 PREDICTED: uncharacterized protein LOC657053 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10401//PF03166 Interferon-regulatory factor 3//MH2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex -- -- Cluster-8309.32195 BF_2 248.46 6.10 1992 642916772 XP_008192547.1 853 1.6e-88 PREDICTED: peptidoglycan-recognition protein LE-like [Tribolium castaneum]>gi|270004832|gb|EFA01280.1| hypothetical protein TcasGA2_TC002790 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9VXN9 410 1.5e-38 Peptidoglycan-recognition protein LE OS=Drosophila melanogaster GN=PGRP-LE PE=1 SV=1 PF05093//PF01510 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//N-acetylmuramoyl-L-alanine amidase GO:0016226//GO:0009252//GO:0006807//GO:0009253 iron-sulfur cluster assembly//peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0051536//GO:0008745 iron-sulfur cluster binding//N-acetylmuramoyl-L-alanine amidase activity GO:0005737 cytoplasm -- -- Cluster-8309.32197 BF_2 23.88 0.85 1456 642914834 XP_008194983.1 729 2.8e-74 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 91 1.68727e-37 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q8VEK6 331 1.6e-29 Inhibitor of growth protein 3 OS=Mus musculus GN=Ing3 PE=1 SV=2 PF00628//PF12090 PHD-finger//Spt20 family -- -- GO:0005515//GO:0003712 protein binding//transcription cofactor activity GO:0005667//GO:0000124 transcription factor complex//SAGA complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.3220 BF_2 9.31 0.40 1250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.32200 BF_2 198.80 2.59 3492 642916254 XP_008190948.1 1579 1.8e-172 PREDICTED: intersectin-2-like isoform X2 [Tribolium castaneum] 746842857 XM_011053352.1 94 8.81731e-39 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- O42287 496 2.9e-48 Intersectin-1 OS=Xenopus laevis GN=itsn1 PE=1 SV=1 PF12763//PF13499//PF14604//PF00018//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Variant SH3 domain//SH3 domain//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.32203 BF_2 700.31 10.23 3151 642939797 XP_970220.2 1795 1.5e-197 PREDICTED: uncharacterized protein LOC658765 [Tribolium castaneum] 642939796 XM_965127.2 668 0 PREDICTED: Tribolium castaneum uncharacterized LOC658765 (LOC658765), mRNA K03649 MUG, TDG TDG/mug DNA glycosylase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03649 Q13569 615 4.1e-62 G/T mismatch-specific thymine DNA glycosylase OS=Homo sapiens GN=TDG PE=1 SV=2 PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- KOG4120 G/T mismatch-specific thymine DNA glycosylase Cluster-8309.32204 BF_2 2132.97 29.12 3351 823397613 XP_012412169.1 387 2.9e-34 PREDICTED: macrophage mannose receptor 1 [Trichechus manatus latirostris] -- -- -- -- -- -- -- -- -- P22897 349 3.0e-31 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03791//PF07840 KNOX2 domain//FadR C-terminal domain GO:0019217 regulation of fatty acid metabolic process GO:0003677//GO:0000062 DNA binding//fatty-acyl-CoA binding GO:0005634 nucleus KOG4297 C-type lectin Cluster-8309.32205 BF_2 79.21 1.02 3533 823397613 XP_012412169.1 387 3.1e-34 PREDICTED: macrophage mannose receptor 1 [Trichechus manatus latirostris] -- -- -- -- -- -- -- -- -- P22897 349 3.2e-31 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03791//PF07840 KNOX2 domain//FadR C-terminal domain GO:0019217 regulation of fatty acid metabolic process GO:0003677//GO:0000062 DNA binding//fatty-acyl-CoA binding GO:0005634 nucleus KOG4297 C-type lectin Cluster-8309.32206 BF_2 220.43 22.55 696 642922790 XP_008193326.1 171 6.7e-10 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32208 BF_2 27.90 0.38 3332 270009742 EFA06190.1 1089 1.1e-115 hypothetical protein TcasGA2_TC009039 [Tribolium castaneum] -- -- -- -- -- K17043 DDX43 ATP-dependent RNA helicase DDX43 http://www.genome.jp/dbget-bin/www_bget?ko:K17043 Q9NXZ2 762 3.9e-79 Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens GN=DDX43 PE=2 SV=2 PF00270//PF07650//PF00013//PF02730//PF04851//PF13014 DEAD/DEAH box helicase//KH domain//KH domain//Aldehyde ferredoxin oxidoreductase, N-terminal domain//Type III restriction enzyme, res subunit//KH domain GO:0055114 oxidation-reduction process GO:0005524//GO:0003723//GO:0016625//GO:0003677//GO:0016787//GO:0016491//GO:0051536//GO:0003676 ATP binding//RNA binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//DNA binding//hydrolase activity//oxidoreductase activity//iron-sulfur cluster binding//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.32209 BF_2 48.14 0.63 3486 189235651 XP_969031.2 2273 6.1e-253 PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917505|ref|XP_008191230.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917507|ref|XP_008191231.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum]>gi|642917509|ref|XP_008191232.1| PREDICTED: uncharacterized protein LOC657480 [Tribolium castaneum] 389611492 AK402738.1 219 2.86724e-108 Papilio xuthus mRNA for dusky, partial cds, sequence id: Px-0224, expressed in epidermis -- -- -- -- O59832 460 4.3e-44 Uncharacterized dipeptidase C965.12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC965.12 PE=3 SV=1 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.32210 BF_2 2027.96 11.50 7666 533200262 XP_005412710.1 597 3.0e-58 PREDICTED: zinc finger protein 347-like isoform X2 [Chinchilla lanigera] 642926231 XM_008196617.1 95 5.40999e-39 PREDICTED: Tribolium castaneum transcriptional activator protein Pur-alpha (LOC662482), transcript variant X2, mRNA -- -- -- -- A6NK75 565 6.3e-56 Zinc finger protein 98 OS=Homo sapiens GN=ZNF98 PE=2 SV=4 PF13912//PF03248//PF16622//PF00096//PF13465 C2H2-type zinc finger//Rer1 family//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.32213 BF_2 673.80 4.29 6864 349584988 BAL03254.1 1877 1.0e-206 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8TMP0 426 7.3e-40 Uncharacterized serpin-like protein MA_2613/MA_2612 OS=Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) GN=MA_2613/MA_2612 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32214 BF_2 130.41 3.35 1916 270013779 EFA10227.1 582 4.1e-57 hypothetical protein TcasGA2_TC012423 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20241 222 9.3e-17 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.32217 BF_2 42.00 2.19 1088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32218 BF_2 11.06 0.64 1006 157114447 XP_001652275.1 848 3.0e-88 AAEL006866-PA [Aedes aegypti]>gi|108877265|gb|EAT41490.1| AAEL006866-PA [Aedes aegypti] 229608898 NM_001159998.1 46 1.19606e-12 Nasonia vitripennis muscle LIM protein (LOC100122977), transcript variant 2, mRNA K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 771 1.1e-80 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412//PF09297 LIM domain//NADH pyrophosphatase zinc ribbon domain -- -- GO:0046872//GO:0008270//GO:0016787 metal ion binding//zinc ion binding//hydrolase activity -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.32219 BF_2 56.62 0.60 4262 91084191 XP_967340.1 2840 0.0e+00 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270008779|gb|EFA05227.1| hypothetical protein TcasGA2_TC015371 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 2117 3.8e-236 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF10399//PF07992//PF05834//PF00732 GMC oxidoreductase//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase GO:0006119//GO:0006066//GO:0006563//GO:0015992//GO:0006544//GO:0055114//GO:0006118//GO:0006566//GO:0016117 oxidative phosphorylation//alcohol metabolic process//L-serine metabolic process//proton transport//glycine metabolic process//oxidation-reduction process//obsolete electron transport//threonine metabolic process//carotenoid biosynthetic process GO:0008121//GO:0016491//GO:0016705//GO:0016614//GO:0008812//GO:0050660 ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.32220 BF_2 825.07 57.83 884 642920912 XP_008192612.1 980 1.3e-103 PREDICTED: outer dense fiber protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8AVY1 287 1.2e-24 Outer dense fiber protein 3 OS=Xenopus laevis GN=odf3 PE=2 SV=1 PF05953 Allatostatin GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity -- -- -- -- Cluster-8309.32221 BF_2 20.98 0.80 1381 642920916 XP_008192614.1 292 1.2e-23 PREDICTED: outer dense fiber protein 3 isoform X3 [Tribolium castaneum] 462345164 APGK01034774.1 40 3.58409e-09 Dendroctonus ponderosae Seq01034784, whole genome shotgun sequence -- -- -- -- Q5EB30 133 1.4e-06 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32222 BF_2 5.07 0.37 861 642920912 XP_008192612.1 717 4.0e-73 PREDICTED: outer dense fiber protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 274 3.9e-23 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32224 BF_2 570.64 23.27 1313 91086893 XP_970527.1 602 1.3e-59 PREDICTED: protein CDV3 homolog isoform X2 [Tribolium castaneum]>gi|270009679|gb|EFA06127.1| hypothetical protein TcasGA2_TC008970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16053 153 6.4e-09 Protein CDV3 homolog OS=Drosophila yakuba GN=GE14456 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32225 BF_2 815.03 29.78 1432 820841547 XP_012339133.1 508 1.2e-48 PREDICTED: LOW QUALITY PROTEIN: tryptase-2-like [Apis florea] -- -- -- -- -- -- -- -- -- P00750 272 1.1e-22 Tissue-type plasminogen activator OS=Homo sapiens GN=PLAT PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32229 BF_2 99.00 26.67 442 828177632 AKK25139.1 192 1.6e-12 odorant binding protein 15 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.32230 BF_2 72.84 0.77 4257 642931082 XP_008196202.1 271 1.0e-20 PREDICTED: aquaporin-12 [Tribolium castaneum] -- -- -- -- -- K08596 SENP7 sentrin-specific protease 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08596 -- -- -- -- PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32231 BF_2 2525.19 45.89 2589 332373408 AEE61845.1 1534 2.2e-167 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 563 3.6e-56 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32235 BF_2 40.68 1.14 1785 642940077 XP_008192917.1 1067 2.2e-113 PREDICTED: UPF0489 protein C5orf22 homolog isoform X1 [Tribolium castaneum]>gi|270016013|gb|EFA12461.1| hypothetical protein TcasGA2_TC010608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PAE6 584 9.1e-59 UPF0489 protein C5orf22 homolog OS=Xenopus laevis PE=2 SV=1 PF01668 SmpB protein -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.32236 BF_2 418.57 3.98 4685 283046738 NP_001164316.1 954 7.3e-100 TAK1-associated binding protein 2 isoform A [Tribolium castaneum]>gi|270012754|gb|EFA09202.1| Tab2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K90 180 1.7e-11 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Mus musculus GN=Tab2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.32237 BF_2 766.16 4.91 6814 546681938 ERL91934.1 5306 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF06320//PF02244//PF12859//PF00057 GCN5-like protein 1 (GCN5L1)//Carboxypeptidase activation peptide//Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A GO:0006508 proteolysis GO:0005515//GO:0004180 protein binding//carboxypeptidase activity GO:0005680//GO:0031083 anaphase-promoting complex//BLOC-1 complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.32239 BF_2 135.13 2.83 2288 546681042 ERL91207.1 2449 1.6e-273 hypothetical protein D910_08545 [Dendroctonus ponderosae] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10714 1662 1.2e-183 Angiotensin-converting enzyme OS=Drosophila melanogaster GN=Ance PE=1 SV=3 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.32240 BF_2 2075.06 56.56 1822 642912940 XP_008201316.1 860 2.2e-89 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80034 565 1.5e-56 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32242 BF_2 18.00 0.42 2069 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32243 BF_2 145.38 4.29 1706 91080051 XP_973222.1 891 5.3e-93 PREDICTED: protein lin-7 homolog C [Tribolium castaneum]>gi|270003212|gb|EEZ99659.1| hypothetical protein TcasGA2_TC002416 [Tribolium castaneum] 805812653 XM_012292327.1 199 1.82262e-97 PREDICTED: Megachile rotundata protein lin-7 homolog C (LOC100884077), transcript variant X5, mRNA -- -- -- -- Q5F425 746 1.4e-77 Protein lin-7 homolog C OS=Gallus gallus GN=LIN7C PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.32244 BF_2 1979.00 49.52 1959 332374712 AEE62497.1 1511 7.8e-165 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O02437 716 4.9e-74 Protein yellow OS=Drosophila subobscura GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32245 BF_2 15.63 0.52 1545 189235643 XP_967729.2 1430 1.5e-155 PREDICTED: metallophosphoesterase 1 [Tribolium castaneum]>gi|270004406|gb|EFA00854.1| hypothetical protein TcasGA2_TC003757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZK82 748 7.6e-78 Metallophosphoesterase 1 OS=Gallus gallus GN=MPPE1 PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3662 Cell division control protein/predicted DNA repair exonuclease Cluster-8309.32246 BF_2 913.66 25.18 1805 91092240 XP_971305.1 1651 4.2e-181 PREDICTED: lysosomal Pro-X carboxypeptidase [Tribolium castaneum]>gi|270014428|gb|EFA10876.1| hypothetical protein TcasGA2_TC001698 [Tribolium castaneum] -- -- -- -- -- K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q2TA14 1163 6.7e-126 Lysosomal Pro-X carboxypeptidase OS=Bos taurus GN=PRCP PE=2 SV=1 PF05577//PF10403//PF00326 Serine carboxypeptidase S28//Rad4 beta-hairpin domain 1//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236//GO:0003677 serine-type peptidase activity//DNA binding -- -- KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.32249 BF_2 913.00 107.63 642 189240098 XP_972684.2 717 3.0e-73 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 [Tribolium castaneum]>gi|270012783|gb|EFA09231.1| hypothetical protein TcasGA2_TC006357 [Tribolium castaneum] -- -- -- -- -- K03966 NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03966 Q1HPL8 531 4.6e-53 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4009 NADH-ubiquinone oxidoreductase, subunit NDUFB10/PDSW Cluster-8309.32250 BF_2 8.00 3.15 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32253 BF_2 912.83 25.70 1773 642937779 XP_008198942.1 1221 3.0e-131 PREDICTED: 26S proteasome non-ATPase regulatory subunit 4 isoform X1 [Tribolium castaneum] 642937778 XM_008200720.1 197 2.45225e-96 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 4 (LOC658092), transcript variant X1, mRNA K03029 PSMD4, RPN10 26S proteasome regulatory subunit N10 http://www.genome.jp/dbget-bin/www_bget?ko:K03029 Q58DA0 880 4.3e-93 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus GN=PSMD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2884 26S proteasome regulatory complex, subunit RPN10/PSMD4 Cluster-8309.32256 BF_2 16.97 0.39 2092 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32257 BF_2 452.93 1.92 10170 642927132 XP_008195151.1 2005 2.1e-221 PREDICTED: far upstream element-binding protein 1 isoform X2 [Tribolium castaneum] 755783784 XM_006939555.2 43 5.79573e-10 PREDICTED: Felis catus far upstream element (FUSE) binding protein 3 (FUBP3), transcript variant X2, mRNA K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 2.6e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF13014//PF13184//PF00013//PF08053//PF07650//PF10192 KH domain//NusA-like KH domain//KH domain//Tryptophanase operon leader peptide//KH domain//Rhodopsin-like GPCR transmembrane domain GO:0019236//GO:0031554//GO:0007186//GO:0031556 response to pheromone//regulation of DNA-templated transcription, termination//G-protein coupled receptor signaling pathway//transcriptional attenuation by ribosome GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.32258 BF_2 470.59 13.13 1787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.32259 BF_2 41.16 6.92 536 642920087 XP_008192199.1 416 2.0e-38 PREDICTED: glycogen synthase kinase-3 beta isoform X4 [Tribolium castaneum]>gi|346654995|gb|AEO44887.1| shaggy [Tribolium castaneum] 645029971 XM_008210300.1 65 1.69336e-23 PREDICTED: Nasonia vitripennis glycogen synthase kinase-3 beta (LOC100117808), transcript variant X7, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 334 2.7e-30 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF00069 Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0658 Glycogen synthase kinase-3 Cluster-8309.3226 BF_2 67.00 3.62 1061 642926497 XP_008191980.1 643 1.9e-64 PREDICTED: iron-sulfur cluster co-chaperone protein HscB, mitochondrial [Tribolium castaneum]>gi|270008449|gb|EFA04897.1| hypothetical protein TcasGA2_TC014961 [Tribolium castaneum] -- -- -- -- -- K04082 hscB, HSCB, HSC20 molecular chaperone HscB http://www.genome.jp/dbget-bin/www_bget?ko:K04082 Q8IWL3 305 1.2e-26 Iron-sulfur cluster co-chaperone protein HscB, mitochondrial OS=Homo sapiens GN=HSCB PE=1 SV=3 PF07743//PF03965 HSCB C-terminal oligomerisation domain//Penicillinase repressor GO:0051259//GO:0045892 protein oligomerization//negative regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG3192 Mitochondrial J-type chaperone Cluster-8309.32260 BF_2 220.25 3.33 3053 86515428 NP_001034540.1 994 1.1e-104 protein decapentaplegic precursor [Tribolium castaneum]>gi|642921157|ref|XP_008192737.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921159|ref|XP_008192738.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|642921161|ref|XP_008192739.1| PREDICTED: protein decapentaplegic isoform X1 [Tribolium castaneum]>gi|2501171|sp|Q26974.1|DECA_TRICA RecName: Full=Protein decapentaplegic; Flags: Precursor>gi|1458196|gb|AAB38392.1| decapentaplegic protein [Tribolium castaneum]>gi|270006465|gb|EFA02913.1| decapentaplegic [Tribolium castaneum] -- -- -- -- -- K04662 BMP2_4 bone morphogenetic protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K04662 Q26974 994 4.5e-106 Protein decapentaplegic OS=Tribolium castaneum GN=dpp PE=3 SV=1 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.32261 BF_2 12.13 1.14 732 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32262 BF_2 1465.58 103.07 882 642914766 XP_008190343.1 385 1.3e-34 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P19236 194 7.5e-14 Mastin OS=Canis familiaris PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32263 BF_2 43.73 0.63 3181 817058472 XP_012250699.1 325 4.3e-27 PREDICTED: tryptase beta-2-like [Athalia rosae] -- -- -- -- -- K01340 E3.4.21.59 tryptase http://www.genome.jp/dbget-bin/www_bget?ko:K01340 P19236 175 4.3e-11 Mastin OS=Canis familiaris PE=1 SV=2 PF00089//PF00647//PF03609 Trypsin//Elongation factor 1 gamma, conserved domain//PTS system sorbose-specific iic component GO:0006508//GO:0009401//GO:0006448//GO:0006414 proteolysis//phosphoenolpyruvate-dependent sugar phosphotransferase system//regulation of translational elongation//translational elongation GO:0004252//GO:0003746 serine-type endopeptidase activity//translation elongation factor activity GO:0005840//GO:0016021 ribosome//integral component of membrane -- -- Cluster-8309.32266 BF_2 207.27 2.41 3889 189235515 XP_970821.2 1626 7.2e-178 PREDICTED: G patch domain-containing protein 1 [Tribolium castaneum]>gi|270003037|gb|EEZ99484.1| hypothetical protein TcasGA2_TC000059 [Tribolium castaneum] -- -- -- -- -- K13123 GPATCH1 G patch domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13123 Q9VUA0 503 4.9e-49 G patch domain-containing protein 1 homolog OS=Drosophila melanogaster GN=CG8833 PE=2 SV=1 PF00462//PF07689//PF00085//PF08534//PF02966//PF01323 Glutaredoxin//KaiB domain//Thioredoxin//Redoxin//Mitosis protein DIM1//DSBA-like thioredoxin domain GO:0048511//GO:0000398//GO:0045454//GO:0006118 rhythmic process//mRNA splicing, via spliceosome//cell redox homeostasis//obsolete electron transport GO:0016491//GO:0015035//GO:0009055 oxidoreductase activity//protein disulfide oxidoreductase activity//electron carrier activity GO:0005681 spliceosomal complex KOG2138 Predicted RNA binding protein, contains G-patch domain Cluster-8309.32268 BF_2 93.53 3.34 1458 91082161 XP_970591.1 962 2.7e-101 PREDICTED: reticulocalbin-2 [Tribolium castaneum]>gi|270007433|gb|EFA03881.1| hypothetical protein TcasGA2_TC014005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X186 396 4.7e-37 Calumenin-A OS=Salmo salar GN=calua PE=2 SV=1 PF13202//PF13499//PF10591//PF00036//PF13833//PF13405 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//EF-hand domain GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.32270 BF_2 1022.00 14.59 3217 91080073 XP_967657.1 2374 1.1e-264 PREDICTED: ER membrane protein complex subunit 1 [Tribolium castaneum]>gi|270003203|gb|EEZ99650.1| hypothetical protein TcasGA2_TC002407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N766 1029 4.1e-110 ER membrane protein complex subunit 1 OS=Homo sapiens GN=EMC1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2103 Uncharacterized conserved protein Cluster-8309.32271 BF_2 955.76 7.06 5950 642933239 XP_008197324.1 860 7.3e-89 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32272 BF_2 67.00 16.47 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32273 BF_2 16.00 0.65 1319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32274 BF_2 35.22 0.53 3076 642913408 XP_008200998.1 193 8.3e-12 PREDICTED: fruitless isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32276 BF_2 44.42 0.75 2768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32277 BF_2 92.53 1.17 3599 577754854 AHH86056.1 1979 7.8e-219 glycoside hydrolase family 31 [Phaedon cochleariae] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 875 3.3e-92 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.32279 BF_2 1017.85 98.83 718 332373648 AEE61965.1 531 1.2e-51 unknown [Dendroctonus ponderosae]>gi|478253491|gb|ENN73818.1| hypothetical protein YQE_09596, partial [Dendroctonus ponderosae]>gi|546679126|gb|ERL89631.1| hypothetical protein D910_06996 [Dendroctonus ponderosae] -- -- -- -- -- K00236 SDHC, SDH3 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00236 Q99643 268 1.6e-22 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Homo sapiens GN=SDHC PE=1 SV=1 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0449 Succinate dehydrogenase, cytochrome b subunit Cluster-8309.32280 BF_2 90.94 9.19 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32281 BF_2 241.54 26.81 664 642930496 XP_008196428.1 735 2.5e-75 PREDICTED: CLIP-associating protein isoform X3 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q9NBD7 466 1.6e-45 CLIP-associating protein OS=Drosophila melanogaster GN=chb PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32284 BF_2 316.55 7.93 1956 546679304 ERL89791.1 641 6.0e-64 hypothetical protein D910_07152 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03188 Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32285 BF_2 27.11 0.45 2795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10220//PF07225 Uncharacterized conserved protein (DUF2146)//NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0006120//GO:0006744//GO:0006814//GO:0000184//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//sodium ion transport//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion -- -- Cluster-8309.32287 BF_2 12.15 0.40 1555 642929303 XP_008195780.1 1194 3.6e-128 PREDICTED: neural cell adhesion molecule 2-like [Tribolium castaneum] 642929302 XM_008197558.1 252 5.71513e-127 PREDICTED: Tribolium castaneum neural cell adhesion molecule 2-like (LOC662052), mRNA -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32288 BF_2 1684.22 25.00 3105 642919756 XP_008192053.1 2379 2.8e-265 PREDICTED: ATP-binding cassette sub-family G member 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 1126 2.2e-121 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01061//PF01926//PF13304//PF00437//PF01079//PF00005//PF03193//PF01637//PF06414 ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Type II/IV secretion system protein//Hint module//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin GO:0006508//GO:0006810 proteolysis//transport GO:0005525//GO:0016887//GO:0016301//GO:0008233//GO:0005524//GO:0003924 GTP binding//ATPase activity//kinase activity//peptidase activity//ATP binding//GTPase activity GO:0016020 membrane -- -- Cluster-8309.32290 BF_2 5.00 0.50 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32291 BF_2 424.44 1.95 9402 642935331 XP_008197971.1 2533 1.2e-282 PREDICTED: regulator of G-protein signaling 7 isoform X2 [Tribolium castaneum] 642935330 XM_008199749.1 821 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC656292), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q80ZD1 950 1.7e-100 Regulator of G-protein signaling 9 OS=Tamias striatus PE=1 SV=1 PF00424//PF00631//PF00610//PF09128 REV protein (anti-repression trans-activator protein)//GGL domain//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Regulator of G protein signalling-like domain GO:0035556//GO:0043087//GO:0007186//GO:0006355//GO:0007165 intracellular signal transduction//regulation of GTPase activity//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0005089//GO:0003700//GO:0004871 Rho guanyl-nucleotide exchange factor activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005737//GO:0005667//GO:0005834//GO:0042025 cytoplasm//transcription factor complex//heterotrimeric G-protein complex//host cell nucleus KOG3589 G protein signaling regulators Cluster-8309.32292 BF_2 1547.66 37.21 2027 642935114 XP_008197893.1 1585 2.1e-173 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X2 [Tribolium castaneum] 830148945 XM_012731330.1 72 8.62821e-27 PREDICTED: Condylura cristata 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), transcript variant X2, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 918 1.9e-97 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF06414//PF01591 Zeta toxin//6-phosphofructo-2-kinase GO:0006000//GO:0006013 fructose metabolic process//mannose metabolic process GO:0016301//GO:0005524//GO:0003873 kinase activity//ATP binding//6-phosphofructo-2-kinase activity -- -- KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.32293 BF_2 2516.64 30.92 3692 91090748 XP_967687.1 314 9.3e-26 PREDICTED: tetraspanin-8 [Tribolium castaneum]>gi|270013954|gb|EFA10402.1| hypothetical protein TcasGA2_TC012641 [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q26499 193 4.1e-13 23 kDa integral membrane protein OS=Schistosoma haematobium PE=2 SV=1 PF02076//PF01757//PF04144//PF00335 Pheromone A receptor//Acyltransferase family//SCAMP family//Tetraspanin family GO:0007606//GO:0015031//GO:0019236//GO:0007186 sensory perception of chemical stimulus//protein transport//response to pheromone//G-protein coupled receptor signaling pathway GO:0016747//GO:0004932 transferase activity, transferring acyl groups other than amino-acyl groups//mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.32294 BF_2 276.91 1.71 7062 91083759 XP_971689.1 2098 2.4e-232 PREDICTED: translocation protein SEC63 homolog [Tribolium castaneum] 241591921 XM_002403988.1 183 6.00406e-88 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 1435 7.6e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF00973//PF01591//PF05470//PF06414 Paramyxovirus nucleocapsid protein//6-phosphofructo-2-kinase//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Zeta toxin GO:0006446//GO:0006413//GO:0006013//GO:0006000 regulation of translational initiation//translational initiation//mannose metabolic process//fructose metabolic process GO:0005524//GO:0003743//GO:0003873//GO:0005198//GO:0031369//GO:0016301 ATP binding//translation initiation factor activity//6-phosphofructo-2-kinase activity//structural molecule activity//translation initiation factor binding//kinase activity GO:0005840//GO:0019013//GO:0005852 ribosome//viral nucleocapsid//eukaryotic translation initiation factor 3 complex KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.32295 BF_2 57.00 3.17 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32296 BF_2 5816.61 13.35 18519 612342210 AHW99830.1 23517 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 2506 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 19821 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00622//PF01365//PF13499//PF13833//PF02815//PF00520//PF00487//PF06423//PF06459 SPRY domain//RIH domain//EF-hand domain pair//EF-hand domain pair//MIR domain//Ion transport protein//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6 GO:0006629//GO:0006811//GO:0006506//GO:0070588//GO:0055085//GO:0006816//GO:0006874 lipid metabolic process//ion transport//GPI anchor biosynthetic process//calcium ion transmembrane transport//transmembrane transport//calcium ion transport//cellular calcium ion homeostasis GO:0016746//GO:0005219//GO:0005515//GO:0005262//GO:0005509//GO:0005216 transferase activity, transferring acyl groups//ryanodine-sensitive calcium-release channel activity//protein binding//calcium channel activity//calcium ion binding//ion channel activity GO:0005789//GO:0016020//GO:0016021//GO:0005622 endoplasmic reticulum membrane//membrane//integral component of membrane//intracellular KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.32297 BF_2 143.20 9.60 911 226968624 YP_002808573.1 942 3.5e-99 cytochrome b [Scylla paramamosain]>gi|225697860|gb|ACO07227.1| cytochrome b [Scylla paramamosain]>gi|403311099|gb|AFR34058.1| cytochrome b (mitochondrion) [Scylla paramamosain] 225697849 FJ827761.1 911 0 Scylla paramamosain mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 B0FWD7 792 3.5e-83 Cytochrome b OS=Aedes aegypti GN=mt:Cyt-b PE=3 SV=1 -- -- -- -- -- -- GO:0016020 membrane KOG4663 Cytochrome b Cluster-8309.32299 BF_2 4.13 0.32 830 642935430 XP_008198007.1 515 1.0e-49 PREDICTED: LOW QUALITY PROTEIN: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 388 2.3e-36 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32302 BF_2 77.17 2.19 1758 225543476 NP_001139385.1 1555 5.6e-170 ventral vein lacking [Tribolium castaneum]>gi|270008227|gb|EFA04675.1| ventral veins lacking [Tribolium castaneum] 225543475 NM_001145913.1 483 0 Tribolium castaneum ventral vein lacking (Vvl), mRNA K09365 POU3F, OTF POU domain transcription factor, class 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09365 P16241 1007 8.0e-108 POU domain protein CF1A OS=Drosophila melanogaster GN=vvl PE=2 SV=5 PF05920//PF00157//PF00046 Homeobox KN domain//Pou domain - N-terminal to homeobox domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.32304 BF_2 119.10 13.29 662 478263116 ENN81509.1 307 1.1e-25 hypothetical protein YQE_02038, partial [Dendroctonus ponderosae]>gi|546672296|gb|ERL84223.1| hypothetical protein D910_01601 [Dendroctonus ponderosae]>gi|546675497|gb|ERL86682.1| hypothetical protein D910_04088 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 225 1.4e-17 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.32306 BF_2 183.18 0.54 14435 642916328 XP_008190975.1 1331 4.3e-143 PREDICTED: glucose transporter type 1 isoform X2 [Tribolium castaneum] 642916327 XM_008192753.1 491 0 PREDICTED: Tribolium castaneum glucose transporter type 1 (LOC663886), transcript variant X2, mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 Q8IRI6 1268 3.6e-137 Glucose transporter type 1 OS=Drosophila melanogaster GN=Glut1 PE=2 SV=4 PF07690//PF00083//PF04440 Major Facilitator Superfamily//Sugar (and other) transporter//Dysbindin (Dystrobrevin binding protein 1) GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG0569 Permease of the major facilitator superfamily Cluster-8309.32307 BF_2 451.39 2.34 8369 270012359 EFA08807.1 1914 6.2e-211 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.2e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF00198//PF13639//PF04564//PF00098//PF14634//PF02817//PF00097//PF01588//PF08783 2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Ring finger domain//U-box domain//Zinc knuckle//zinc-RING finger domain//e3 binding domain//Zinc finger, C3HC4 type (RING finger)//Putative tRNA binding domain//DWNN domain GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0016746//GO:0004842//GO:0000049//GO:0005515//GO:0008270//GO:0003676//GO:0046872 transferase activity, transferring acyl groups//ubiquitin-protein transferase activity//tRNA binding//protein binding//zinc ion binding//nucleic acid binding//metal ion binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.32308 BF_2 12.00 1.76 573 817061123 XP_012252151.1 259 3.4e-20 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.32309 BF_2 59.12 0.33 7743 642928597 XP_008199971.1 5478 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q80XK6 1977 1.2e-219 Autophagy-related protein 2 homolog B OS=Mus musculus GN=Atg2b PE=1 SV=3 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.32310 BF_2 26.22 1.00 1383 91083531 XP_973193.1 367 2.5e-32 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q8K354 165 2.7e-10 Carbonyl reductase [NADPH] 3 OS=Mus musculus GN=Cbr3 PE=2 SV=1 PF06112 Gammaherpesvirus capsid protein GO:0055114 oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity GO:0019028 viral capsid -- -- Cluster-8309.32312 BF_2 4235.55 28.68 6465 642924534 XP_008194335.1 2139 3.9e-237 PREDICTED: junctophilin-1 isoform X2 [Tribolium castaneum] 642924533 XM_008196113.1 493 0 PREDICTED: Tribolium castaneum junctophilin-1 (LOC662408), transcript variant X2, mRNA K19530 JPH junctophilin http://www.genome.jp/dbget-bin/www_bget?ko:K19530 Q9ET80 1235 1.1e-133 Junctophilin-1 OS=Mus musculus GN=Jph1 PE=2 SV=1 PF06112//PF04072//PF01022 Gammaherpesvirus capsid protein//Leucine carboxyl methyltransferase//Bacterial regulatory protein, arsR family GO:0006355//GO:0032259 regulation of transcription, DNA-templated//methylation GO:0008168//GO:0003700 methyltransferase activity//transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0005667 viral capsid//transcription factor complex KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.32313 BF_2 1354.97 126.28 736 478251713 ENN72167.1 337 4.0e-29 hypothetical protein YQE_11223, partial [Dendroctonus ponderosae]>gi|546680962|gb|ERL91136.1| hypothetical protein D910_08476 [Dendroctonus ponderosae] -- -- -- -- -- K03960 NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03960 -- -- -- -- PF07225 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0015992//GO:0006814//GO:0006744//GO:0006120 proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005739 mitochondrion -- -- Cluster-8309.32316 BF_2 1017.43 78.12 832 759040576 XP_011329079.1 207 5.4e-14 PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi]>gi|759040578|ref|XP_011329080.1| PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi]>gi|759040580|ref|XP_011329081.1| PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi]>gi|759040582|ref|XP_011329082.1| PREDICTED: AN1-type zinc finger protein 6 isoform X1 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- O76080 130 1.9e-06 AN1-type zinc finger protein 5 OS=Homo sapiens GN=ZFAND5 PE=1 SV=1 PF01754 A20-like zinc finger -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- KOG3173 Predicted Zn-finger protein Cluster-8309.32317 BF_2 79.21 0.39 8880 478261064 ENN80628.1 201 2.8e-12 hypothetical protein YQE_02949, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00097//PF01754 Zinc finger, C3HC4 type (RING finger)//A20-like zinc finger -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.32319 BF_2 1.00 11.37 230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32321 BF_2 359.00 5.88 2843 642940062 XP_967869.2 1528 1.2e-166 PREDICTED: synembryn-A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29IC2 762 3.3e-79 Synembryn OS=Drosophila pseudoobscura pseudoobscura GN=ric8a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4464 Signaling protein RIC-8/synembryn (regulates neurotransmitter secretion) Cluster-8309.32322 BF_2 151.25 4.26 1773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32324 BF_2 92.46 2.20 2044 332374554 AEE62418.1 1390 8.8e-151 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 853 6.7e-90 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.32327 BF_2 52.00 1.55 1695 -- -- -- -- -- 642931318 XM_008198308.1 34 9.56805e-06 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X30, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32328 BF_2 1206.98 13.96 3904 91095209 XP_968413.1 1384 8.3e-150 PREDICTED: mitochondrial inner membrane protein OXA1L [Tribolium castaneum]>gi|270015977|gb|EFA12425.1| hypothetical protein TcasGA2_TC001816 [Tribolium castaneum] -- -- -- -- -- K03217 yidC, spoIIIJ, OXA1 YidC/Oxa1 family membrane protein insertase http://www.genome.jp/dbget-bin/www_bget?ko:K03217 Q8BGA9 736 4.7e-76 Mitochondrial inner membrane protein OXA1L OS=Mus musculus GN=Oxa1l PE=2 SV=1 PF02096//PF02703 60Kd inner membrane protein//Early E1A protein GO:0006355//GO:0051205//GO:0019048 regulation of transcription, DNA-templated//protein insertion into membrane//modulation by virus of host morphology or physiology -- -- GO:0016021 integral component of membrane KOG3012 Uncharacterized conserved protein Cluster-8309.3233 BF_2 99.00 1.22 3678 91092448 XP_969433.1 4557 0.0e+00 PREDICTED: unconventional myosin-IXa [Tribolium castaneum] 665794026 XM_008546468.1 291 2.86026e-148 PREDICTED: Microplitis demolitor unconventional myosin-IXb (LOC103569255), transcript variant X2, mRNA K16677 DACHS dachs http://www.genome.jp/dbget-bin/www_bget?ko:K16677 O43795 598 4.5e-60 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF00063//PF06414//PF00612 Myosin head (motor domain)//Zeta toxin//IQ calmodulin-binding motif -- -- GO:0003774//GO:0016301//GO:0005524//GO:0005515 motor activity//kinase activity//ATP binding//protein binding GO:0016459 myosin complex KOG0160 Myosin class V heavy chain Cluster-8309.32330 BF_2 1223.38 10.43 5195 91084663 XP_967750.1 2228 1.5e-247 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 6.34426e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 O57429 1001 1.2e-106 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF15957//PF12422//PF05427//PF00443 Commissureless//Condensin II non structural maintenance of chromosomes subunit//Acidic fibroblast growth factor binding (FIBP)//Ubiquitin carboxyl-terminal hydrolase GO:0007411//GO:0016579 axon guidance//protein deubiquitination GO:0036459//GO:0017134//GO:0016787 ubiquitinyl hydrolase activity//fibroblast growth factor binding//hydrolase activity GO:0005634 nucleus -- -- Cluster-8309.32331 BF_2 351.69 2.70 5730 642925017 XP_008194137.1 3852 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X1 [Tribolium castaneum] 462328174 APGK01040787.1 46 7.00218e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.9e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.32332 BF_2 327.11 3.95 3751 91077138 XP_971446.1 1025 3.4e-108 PREDICTED: dnaJ homolog subfamily A member 1 [Tribolium castaneum]>gi|270001716|gb|EEZ98163.1| hypothetical protein TcasGA2_TC000590 [Tribolium castaneum] 817197334 XM_012418859.1 104 2.61669e-44 PREDICTED: Orussus abietinus dnaJ homolog subfamily A member 1 (LOC105696421), transcript variant X2, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 P63037 769 6.8e-80 DnaJ homolog subfamily A member 1 OS=Mus musculus GN=Dnaja1 PE=1 SV=1 PF00684//PF01155//PF16685//PF05209//PF00018 DnaJ central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//zinc RING finger of MSL2//Septum formation inhibitor MinC, N-terminal domain//SH3 domain GO:0006260//GO:0009408//GO:0006464//GO:0006457//GO:0051302 DNA replication//response to heat//cellular protein modification process//protein folding//regulation of cell division GO:0046872//GO:0051082//GO:0061630//GO:0016151//GO:0005515//GO:0005524//GO:0031072 metal ion binding//unfolded protein binding//ubiquitin protein ligase activity//nickel cation binding//protein binding//ATP binding//heat shock protein binding GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.32333 BF_2 937.28 34.61 1420 91088847 XP_970872.1 1342 2.2e-145 PREDICTED: adenosine kinase [Tribolium castaneum]>gi|270011602|gb|EFA08050.1| hypothetical protein TcasGA2_TC005644 [Tribolium castaneum] -- -- -- -- -- K00856 E2.7.1.20, ADK adenosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00856 P55264 930 5.5e-99 Adenosine kinase OS=Mus musculus GN=Adk PE=1 SV=2 PF00113 Enolase, C-terminal TIM barrel domain GO:0006096//GO:0006144//GO:0006167//GO:0006166//GO:0006094//GO:0009094//GO:0006571//GO:0000162 glycolytic process//purine nucleobase metabolic process//AMP biosynthetic process//purine ribonucleoside salvage//gluconeogenesis//L-phenylalanine biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0004001//GO:0004634//GO:0016773//GO:0000287 adenosine kinase activity//phosphopyruvate hydratase activity//phosphotransferase activity, alcohol group as acceptor//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.32334 BF_2 20.15 0.61 1677 91089445 XP_966341.1 696 2.1e-70 PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|91089447|ref|XP_975797.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|270012573|gb|EFA09021.1| hypothetical protein TcasGA2_TC006730 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q99PT1 419 1.2e-39 Rho GDP-dissociation inhibitor 1 OS=Mus musculus GN=Arhgdia PE=1 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.32335 BF_2 20.31 1.42 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.32339 BF_2 290.78 3.92 3393 642929984 XP_008196053.1 2642 9.7e-296 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 317 9.28318e-163 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1596 7.8e-176 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF07701//PF06330//PF00069//PF07714//PF00211 Heme NO binding associated//Trichodiene synthase (TRI5)//Protein kinase domain//Protein tyrosine kinase//Adenylate and Guanylate cyclase catalytic domain GO:0046039//GO:0006182//GO:0016114//GO:0006144//GO:0006468//GO:0016106//GO:0009190//GO:0035556 GTP metabolic process//cGMP biosynthetic process//terpenoid biosynthetic process//purine nucleobase metabolic process//protein phosphorylation//sesquiterpenoid biosynthetic process//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0005524//GO:0004383//GO:0016849//GO:0045482//GO:0004672 ATP binding//guanylate cyclase activity//phosphorus-oxygen lyase activity//trichodiene synthase activity//protein kinase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.32340 BF_2 1178.04 28.49 2017 270011245 EFA07693.1 1446 2.8e-157 hypothetical protein TcasGA2_TC030782, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZIF1 469 2.2e-45 Adipocyte plasma membrane-associated protein OS=Gallus gallus GN=APMAP PE=2 SV=1 PF01731//PF01436//PF03088 Arylesterase//NHL repeat//Strictosidine synthase GO:0016114//GO:0009058//GO:0042432 terpenoid biosynthetic process//biosynthetic process//indole biosynthetic process GO:0016844//GO:0004064//GO:0005515 strictosidine synthase activity//arylesterase activity//protein binding -- -- KOG1520 Predicted alkaloid synthase/Surface mucin Hemomucin Cluster-8309.32341 BF_2 1485.87 4.72 13468 189234010 XP_972656.2 5133 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2424 3.0e-271 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF08926//PF00412//PF07714//PF13180//PF00069//PF06293//PF00595 Domain of unknown function (DUF1908)//LIM domain//Protein tyrosine kinase//PDZ domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain (Also known as DHR or GLGF) GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0008270//GO:0016773//GO:0000287//GO:0004674//GO:0004672//GO:0005524//GO:0005515 zinc ion binding//phosphotransferase activity, alcohol group as acceptor//magnesium ion binding//protein serine/threonine kinase activity//protein kinase activity//ATP binding//protein binding GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.32344 BF_2 738.00 19.39 1879 470011979 AGI03845.1 1469 5.6e-160 cytochrome P450 6BQ9 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1008 6.6e-108 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.32345 BF_2 109.82 13.72 622 642933218 XP_008197312.1 483 4.0e-46 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 269 1.1e-22 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00083//PF05363 Major Facilitator Superfamily//Sugar (and other) transporter//Herpesvirus US12 family GO:0055085//GO:0019049 transmembrane transport//evasion or tolerance of host defenses by virus GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.32346 BF_2 619.14 4.53 6007 642911031 XP_008193516.1 826 6.5e-85 PREDICTED: cytoplasmic polyadenylation element-binding protein 2 [Tribolium castaneum] 462332955 APGK01039143.1 249 1.0442e-124 Dendroctonus ponderosae Seq01039153, whole genome shotgun sequence K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q9VSR3 737 5.6e-76 Probable RNA-binding protein orb2 OS=Drosophila melanogaster GN=orb2 PE=1 SV=1 PF00643//PF16367//PF00076 B-box zinc finger//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.32347 BF_2 64.62 0.86 3415 642923285 XP_008193690.1 1709 1.5e-187 PREDICTED: venom dipeptidyl peptidase 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 953 2.8e-101 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF00326//PF02129//PF03583//PF00930 Prolyl oligopeptidase family//X-Pro dipeptidyl-peptidase (S15 family)//Secretory lipase//Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508//GO:0016042//GO:0046486 proteolysis//lipid catabolic process//glycerolipid metabolic process GO:0016787//GO:0008236//GO:0004806 hydrolase activity//serine-type peptidase activity//triglyceride lipase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.32348 BF_2 33.68 0.48 3217 283046730 NP_001164311.1 1663 3.0e-182 tyramine/octopamine receptor [Tribolium castaneum]>gi|289191348|ref|NP_001164312.1| tyramine/octopamine receptor [Tribolium castaneum]>gi|642912074|ref|XP_008200790.1| PREDICTED: tyramine/octopamine receptor isoform X1 [Tribolium castaneum]>gi|270002886|gb|EEZ99333.1| hypothetical protein TcasGA2_TC004545 [Tribolium castaneum]>gi|485836728|tpg|DAA64498.1| TPA_inf: putative octopamine/tyramine receptor [Tribolium castaneum] 118782661 XM_312420.3 177 5.88682e-85 Anopheles gambiae str. PEST AGAP002519-PA (GPRTYR) mRNA, complete cds K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25188 1303 7.0e-142 Octopamine receptor OS=Heliothis virescens PE=2 SV=1 PF00001//PF01496//PF08496//PF02480 7 transmembrane receptor (rhodopsin family)//V-type ATPase 116kDa subunit family//Peptidase family S49 N-terminal//Alphaherpesvirus glycoprotein E GO:0007187//GO:0015991//GO:0007186//GO:0015992 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//ATP hydrolysis coupled proton transport//G-protein coupled receptor signaling pathway//proton transport GO:0004930//GO:0004989//GO:0015078//GO:0004252 G-protein coupled receptor activity//octopamine receptor activity//hydrogen ion transmembrane transporter activity//serine-type endopeptidase activity GO:0005886//GO:0016021//GO:0016020//GO:0033179 plasma membrane//integral component of membrane//membrane//proton-transporting V-type ATPase, V0 domain KOG3656 FOG: 7 transmembrane receptor Cluster-8309.32350 BF_2 199.00 12.48 954 91078168 XP_966793.1 719 2.6e-73 PREDICTED: J domain-containing protein CG6693 [Tribolium castaneum]>gi|270002352|gb|EEZ98799.1| hypothetical protein TcasGA2_TC001365 [Tribolium castaneum] -- -- -- -- -- K09529 DNAJC9 DnaJ homolog subfamily C member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09529 Q8WXX5 426 1.0e-40 DnaJ homolog subfamily C member 9 OS=Homo sapiens GN=DNAJC9 PE=1 SV=1 PF03461 TRCF domain GO:0006281 DNA repair -- -- -- -- KOG0719 Molecular chaperone (DnaJ superfamily) Cluster-8309.32351 BF_2 113.00 5.82 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32354 BF_2 535.00 5.65 4245 642913805 XP_008201166.1 2763 1.1e-309 PREDICTED: protein wings apart-like isoform X1 [Tribolium castaneum]>gi|270002763|gb|EEZ99210.1| wings apart-like protein [Tribolium castaneum] 662196926 XM_008473295.1 131 2.90238e-59 PREDICTED: Diaphorina citri protein wings apart-like (LOC103508723), mRNA -- -- -- -- Q9W517 1304 7.0e-142 Protein wings apart-like OS=Drosophila melanogaster GN=wapl PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2152 Sister chromatid cohesion protein Cluster-8309.32355 BF_2 1635.84 15.12 4814 642924809 XP_008194049.1 4188 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X1 [Tribolium castaneum] 749755570 XM_011141969.1 132 9.16063e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 6.0e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.32359 BF_2 433.32 4.01 4802 546676723 ERL87679.1 1323 1.2e-142 hypothetical protein D910_05069 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24478 594 1.7e-59 Centrosome-associated zinc finger protein CP190 OS=Drosophila melanogaster GN=Cp190 PE=1 SV=2 PF16622//PF00651//PF00096 zinc-finger C2H2-type//BTB/POZ domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.32360 BF_2 312.36 1.61 8408 189233577 XP_968497.2 1756 1.3e-192 PREDICTED: protein capicua homolog isoform X1 [Tribolium castaneum]>gi|270015125|gb|EFA11573.1| capicua [Tribolium castaneum] 642910253 XM_008200351.1 160 4.36723e-75 PREDICTED: Tribolium castaneum capicua (LOC656907), transcript variant X2, mRNA -- -- -- -- Q96RK0 381 1.5e-34 Protein capicua homolog OS=Homo sapiens GN=CIC PE=1 SV=2 PF08288 PIGA (GPI anchor biosynthesis) GO:0006506 GPI anchor biosynthetic process -- -- -- -- KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.32362 BF_2 26.35 0.66 1970 642928376 XP_008192718.1 941 9.8e-99 PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X2 [Tribolium castaneum] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 852 8.4e-90 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF02882//PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0009396//GO:0046487//GO:0055114 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//oxidation-reduction process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.32363 BF_2 3345.00 61.89 2548 332376402 AEE63341.1 2678 4.9e-300 unknown [Dendroctonus ponderosae] 642915759 XM_962024.2 567 0 PREDICTED: Tribolium castaneum transmembrane 9 superfamily member 3 (LOC655481), mRNA K17087 TM9SF3 transmembrane 9 superfamily member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17087 Q9ET30 2315 2.5e-259 Transmembrane 9 superfamily member 3 OS=Mus musculus GN=Tm9sf3 PE=1 SV=1 PF02990//PF12297 Endomembrane protein 70//Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- GO:0016021 integral component of membrane KOG1277 Endosomal membrane proteins, EMP70 Cluster-8309.32364 BF_2 64.69 0.71 4098 189235374 XP_001809693.1 1695 7.6e-186 PREDICTED: potassium voltage-gated channel protein Shaker isoform X1 [Tribolium castaneum] 642916511 XM_001809641.2 818 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X1, mRNA K04874 KCNA1 potassium voltage-gated channel Shaker-related subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04874 P08510 1552 1.2e-170 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.32365 BF_2 26.00 0.57 2180 478256535 ENN76719.1 356 7.4e-31 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 573890600 XM_006632998.1 35 3.43752e-06 PREDICTED: Lepisosteus oculatus zinc finger protein ZIC 5-like (LOC102698757), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 296 2.8e-25 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF02892//PF13912//PF00096//PF02176//PF13465//PF00130 BED zinc finger//C2H2-type zinc finger//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.32366 BF_2 93.25 0.68 6048 642929749 XP_008195960.1 2131 3.1e-236 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.07019e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF00008//PF06112//PF03067//PF09172//PF05887//PF05433 EGF-like domain//Gammaherpesvirus capsid protein//Chitin binding domain//Domain of unknown function (DUF1943)//Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain GO:0006869 lipid transport GO:0005319//GO:0005515 lipid transporter activity//protein binding GO:0019028//GO:0016020//GO:0019867 viral capsid//membrane//outer membrane -- -- Cluster-8309.32367 BF_2 669.33 14.89 2167 642915291 XP_008190557.1 1455 2.7e-158 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 676 2.4e-69 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.32368 BF_2 326.78 4.39 3404 642922826 XP_008193342.1 988 6.0e-104 PREDICTED: rhodopsin, GQ-coupled isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P43119 167 3.9e-10 Prostacyclin receptor OS=Homo sapiens GN=PTGIR PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.32374 BF_2 313.00 41.58 602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32378 BF_2 830.39 2.00 17666 270010335 EFA06783.1 17262 0.0e+00 hypothetical protein TcasGA2_TC009719 [Tribolium castaneum] 620960012 XM_007666944.1 166 4.2473e-78 PREDICTED: Ornithorhynchus anatinus dynein, axonemal, heavy chain 10 (DNAH10), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8IVF4 11107 0.0e+00 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 PF03028//PF05197//PF02877//PF00004//PF02602//PF07728//PF15957//PF02562 Dynein heavy chain and region D6 of dynein motor//TRIC channel//Poly(ADP-ribose) polymerase, regulatory domain//ATPase family associated with various cellular activities (AAA)//Uroporphyrinogen-III synthase HemD//AAA domain (dynein-related subfamily)//Commissureless//PhoH-like protein GO:0006812//GO:0007017//GO:0015672//GO:0007018//GO:0007411//GO:0006471//GO:0006783//GO:0033014//GO:0015994 cation transport//microtubule-based process//monovalent inorganic cation transport//microtubule-based movement//axon guidance//protein ADP-ribosylation//heme biosynthetic process//tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0016887//GO:0004852//GO:0005524//GO:0005261//GO:0003950//GO:0003777 ATPase activity//uroporphyrinogen-III synthase activity//ATP binding//cation channel activity//NAD+ ADP-ribosyltransferase activity//microtubule motor activity GO:0016020//GO:0030286//GO:0005874 membrane//dynein complex//microtubule -- -- Cluster-8309.32383 BF_2 1204.27 61.60 1105 736247237 XP_010786870.1 142 2.4e-06 PREDICTED: golgin subfamily A member 6-like protein 22 [Notothenia coriiceps] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32384 BF_2 87.05 0.80 4813 728417168 AIY68335.1 1997 8.5e-221 esterase, partial [Leptinotarsa decemlineata] 801385926 XM_012200861.1 84 4.41456e-33 PREDICTED: Atta cephalotes transcription initiation factor IIE subunit beta (LOC105619342), mRNA -- -- -- -- Q8R0W5 424 8.8e-40 Carboxylesterase 4A OS=Mus musculus GN=Ces4a PE=2 SV=2 PF07859//PF02230//PF01764//PF02186//PF04636 alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Lipase (class 3)//TFIIE beta subunit core domain//PA26 p53-induced protein (sestrin) GO:0008152//GO:0006629//GO:0006367//GO:1901031 metabolic process//lipid metabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species GO:0016787 hydrolase activity GO:0005634 nucleus KOG1516 Carboxylesterase and related proteins Cluster-8309.32385 BF_2 96.84 0.80 5334 390362249 XP_001190749.2 755 9.8e-77 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 713 3.0e-73 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.32386 BF_2 85.60 65.51 335 91083251 XP_974045.1 525 2.9e-51 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 780659103 XM_011694063.1 116 4.54408e-52 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 471 2.2e-46 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF00270 DEAD/DEAH box helicase -- -- GO:0003676//GO:0005524//GO:0008026 nucleic acid binding//ATP binding//ATP-dependent helicase activity -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.32387 BF_2 173.85 13.50 826 332376787 AEE63533.1 838 3.6e-87 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 617645164 XM_007532444.1 182 2.43686e-88 PREDICTED: Erinaceus europaeus DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (DDX39A), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 804 1.3e-84 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.32388 BF_2 109.09 5.63 1098 332376787 AEE63533.1 700 4.8e-71 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 617645164 XM_007532444.1 165 9.23197e-79 PREDICTED: Erinaceus europaeus DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (DDX39A), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 666 1.7e-68 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.32389 BF_2 433.46 29.40 904 478254618 ENN74861.1 748 1.1e-76 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 341 6.9e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF07043//PF06687//PF00230 Protein of unknown function (DUF1328)//SUR7/PalI family//Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8309.32390 BF_2 10.34 0.87 785 91086139 XP_968980.1 363 4.1e-32 PREDICTED: uncharacterized protein LOC657426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02952 L-fucose isomerase, C-terminal domain GO:0006004//GO:0006000//GO:0006013 fucose metabolic process//fructose metabolic process//mannose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm -- -- Cluster-8309.32391 BF_2 56.66 4.33 835 91086139 XP_968980.1 363 4.4e-32 PREDICTED: uncharacterized protein LOC657426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02952 L-fucose isomerase, C-terminal domain GO:0006000//GO:0006013//GO:0006004 fructose metabolic process//mannose metabolic process//fucose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm -- -- Cluster-8309.32395 BF_2 56.00 0.80 3214 546684320 ERL94025.1 191 1.5e-11 hypothetical protein D910_11309 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32396 BF_2 708.62 8.60 3733 546679118 ERL89623.1 1551 3.4e-169 hypothetical protein D910_06988 [Dendroctonus ponderosae] 195146567 XM_002014220.1 155 1.16118e-72 Drosophila persimilis gpdh (Dper\Gpdh), mRNA K00006 GPD1 glycerol-3-phosphate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00006 O97463 1392 3.9e-152 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Drosophila kanekoi GN=Gpdh1 PE=3 SV=3 PF01210//PF07479//PF12153//PF03523 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus//LPS binding domain of CAP18 (C terminal)//Macrophage scavenger receptor GO:0046486//GO:0005975//GO:0055114//GO:0042742//GO:0046168//GO:0007165//GO:0006072//GO:0006898 glycerolipid metabolic process//carbohydrate metabolic process//oxidation-reduction process//defense response to bacterium//glycerol-3-phosphate catabolic process//signal transduction//glycerol-3-phosphate metabolic process//receptor-mediated endocytosis GO:0004367//GO:0005044//GO:0051287//GO:0016616 glycerol-3-phosphate dehydrogenase [NAD+] activity//scavenger receptor activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0009331//GO:0016020 glycerol-3-phosphate dehydrogenase complex//membrane KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase Cluster-8309.32398 BF_2 54.91 1.27 2098 332375618 AEE62950.1 1358 4.6e-147 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02175 BRN putative enzyme (brainiac) http://www.genome.jp/dbget-bin/www_bget?ko:K02175 Q24157 635 1.3e-64 Beta-1,3-galactosyltransferase brn OS=Drosophila melanogaster GN=brn PE=2 SV=2 PF12919//PF01762//PF02434//PF11365 TcdA/TcdB catalytic glycosyltransferase domain//Galactosyltransferase//Fringe-like//Protein of unknown function (DUF3166) GO:0006486//GO:0010506 protein glycosylation//regulation of autophagy GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020//GO:0005615 membrane//extracellular space -- -- Cluster-8309.32399 BF_2 994.63 6.27 6927 91091256 XP_968850.1 1918 1.8e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.6e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF00180//PF04117//PF01398 Isocitrate/isopropylmalate dehydrogenase//Mpv17 / PMP22 family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006102//GO:0006749//GO:0019643//GO:0006099//GO:0055114 isocitrate metabolic process//glutathione metabolic process//reductive tricarboxylic acid cycle//tricarboxylic acid cycle//oxidation-reduction process GO:0016616//GO:0051287//GO:0005515//GO:0004450//GO:0000287 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//protein binding//isocitrate dehydrogenase (NADP+) activity//magnesium ion binding GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.32400 BF_2 8.41 1.56 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32402 BF_2 2654.31 83.50 1617 663070911 NP_001284604.1 1060 1.3e-112 ras-related protein Rab-7a [Tribolium castaneum]>gi|642930896|ref|XP_008196131.1| PREDICTED: ras-related protein Rab-7a [Tribolium castaneum]>gi|629511287|gb|AHY84717.1| ras-related protein Rab-7a [Tribolium castaneum] -- -- -- -- -- K07897 RAB7A Ras-related protein Rab-7A http://www.genome.jp/dbget-bin/www_bget?ko:K07897 P09527 880 3.9e-93 Ras-related protein Rab-7a OS=Rattus norvegicus GN=Rab7a PE=1 SV=2 PF03193//PF01637//PF04670//PF00071//PF00735//PF08477//PF01926//PF00025 Protein of unknown function, DUF258//Archaeal ATPase//Gtr1/RagA G protein conserved region//Ras family//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0394 Ras-related GTPase Cluster-8309.32403 BF_2 194.00 9.58 1134 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32404 BF_2 213.81 29.73 588 91090444 XP_966925.1 587 3.3e-58 PREDICTED: DNA-directed RNA polymerase II subunit RPB11 [Tribolium castaneum]>gi|270013848|gb|EFA10296.1| hypothetical protein TcasGA2_TC012511 [Tribolium castaneum] -- -- -- -- -- K03008 RPB11, POLR2J DNA-directed RNA polymerase II subunit RPB11 http://www.genome.jp/dbget-bin/www_bget?ko:K03008 Q9VJE4 549 3.4e-55 DNA-directed RNA polymerase II subunit RPB11 OS=Drosophila melanogaster GN=Rpb11 PE=3 SV=1 PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046983 DNA binding//DNA-directed RNA polymerase activity//protein dimerization activity GO:0005730 nucleolus KOG4392 RNA polymerase, subunit L Cluster-8309.32405 BF_2 3.19 1.01 418 332374220 AEE62251.1 467 1.9e-44 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03008 RPB11, POLR2J DNA-directed RNA polymerase II subunit RPB11 http://www.genome.jp/dbget-bin/www_bget?ko:K03008 Q9VJE4 442 6.2e-43 DNA-directed RNA polymerase II subunit RPB11 OS=Drosophila melanogaster GN=Rpb11 PE=3 SV=1 PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006351 transcription, DNA-templated GO:0046983 protein dimerization activity -- -- KOG4392 RNA polymerase, subunit L Cluster-8309.32406 BF_2 1156.70 58.66 1112 674304018 AIL23540.1 547 2.7e-53 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 408 1.5e-38 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF02798//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32408 BF_2 7.31 0.33 1201 91090714 XP_975034.1 170 1.5e-09 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32409 BF_2 415.00 9.44 2127 478253644 ENN73948.1 447 2.0e-41 hypothetical protein YQE_09450, partial [Dendroctonus ponderosae]>gi|546684551|gb|ERL94179.1| hypothetical protein D910_11461 [Dendroctonus ponderosae] -- -- -- -- -- K14527 RPP20, POP7 ribonuclease P/MRP protein subunit RPP20 http://www.genome.jp/dbget-bin/www_bget?ko:K14527 Q969S6 233 5.5e-18 Transmembrane protein 203 OS=Homo sapiens GN=TMEM203 PE=2 SV=1 PF12861//PF12328//PF04564//PF02891//PF11789//PF01918 Anaphase-promoting complex subunit 11 RING-H2 finger//Rpp20 subunit of nuclear RNase MRP and P//U-box domain//MIZ/SP-RING zinc finger//Zinc-finger of the MIZ type in Nse subunit//Alba GO:0051252//GO:0008033//GO:0016567 regulation of RNA metabolic process//tRNA processing//protein ubiquitination GO:0003676//GO:0008270//GO:0004842//GO:0004526 nucleic acid binding//zinc ion binding//ubiquitin-protein transferase activity//ribonuclease P activity GO:0005680//GO:0030677//GO:0005634 anaphase-promoting complex//ribonuclease P complex//nucleus KOG2979 Protein involved in DNA repair Cluster-8309.32410 BF_2 402.50 3.67 4875 642935314 XP_008197964.1 2079 2.7e-230 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X13 [Tribolium castaneum] 780158183 XM_011684374.1 51 9.8875e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 O42184 1135 3.2e-122 CAP-Gly domain-containing linker protein 1 OS=Gallus gallus GN=CLIP1 PE=2 SV=1 PF00038//PF10186 Intermediate filament protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy GO:0005198 structural molecule activity GO:0005882 intermediate filament -- -- Cluster-8309.32411 BF_2 2054.00 36.04 2671 91091768 XP_969459.1 560 2.0e-54 PREDICTED: CDGSH iron-sulfur domain-containing protein 2 homolog [Tribolium castaneum]>gi|270001086|gb|EEZ97533.1| hypothetical protein TcasGA2_TC011381 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JYJ2 499 9.8e-49 CDGSH iron-sulfur domain-containing protein 2 homolog OS=Drosophila grimshawi GN=GH14305 PE=3 SV=1 PF10660//PF09360 Iron-containing outer mitochondrial membrane protein N-terminus//Iron-binding zinc finger CDGSH type -- -- GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG3461 CDGSH-type Zn-finger containing protein Cluster-8309.32413 BF_2 287.38 40.09 587 546677100 ERL88001.1 626 9.8e-63 hypothetical protein D910_05390 [Dendroctonus ponderosae] 641661239 XM_008183586.1 194 3.63134e-95 PREDICTED: Acyrthosiphon pisum chromatin modifying protein 2A (Chmp2a), transcript variant X7, mRNA K12191 CHMP2A charged multivesicular body protein 2A http://www.genome.jp/dbget-bin/www_bget?ko:K12191 Q6IP52 544 1.3e-54 Charged multivesicular body protein 2a OS=Xenopus laevis GN=chmp2a PE=2 SV=1 PF01346//PF03357//PF11698 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Snf7//V-ATPase subunit H GO:0007034//GO:0015991//GO:0006457 vacuolar transport//ATP hydrolysis coupled proton transport//protein folding GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.32414 BF_2 134.11 1.12 5314 769848297 XP_011635512.1 1496 1.2e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.8e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF03006//PF02421//PF03193//PF00176//PF01926 Haemolysin-III related//Ferrous iron transport protein B//Protein of unknown function, DUF258//SNF2 family N-terminal domain//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0003924//GO:0005525//GO:0005524//GO:0015093 GTPase activity//GTP binding//ATP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.32416 BF_2 12.20 0.41 1531 642933527 XP_008197456.1 898 7.4e-94 PREDICTED: protein alan shepard isoform X3 [Tribolium castaneum] 462283408 APGK01056946.1 55 1.82731e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 4.4e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF00076//PF09726//PF01080//PF07267 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein//Presenilin//Nucleopolyhedrovirus capsid protein P87 -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4733 FOG: RRM domain Cluster-8309.32420 BF_2 5537.13 190.98 1500 91093044 XP_966517.1 1581 4.6e-173 PREDICTED: lysosomal aspartic protease [Tribolium castaneum]>gi|270002651|gb|EEZ99098.1| hypothetical protein TcasGA2_TC004989 [Tribolium castaneum] 17981529 AF454831.1 697 0 AF454831 Apriona germari cathepsin D mRNA, complete cds K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 1436 1.2e-157 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF07966//PF00026 A1 Propeptide//Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-8309.32421 BF_2 55.46 1.45 1891 329754204 AEC03508.1 1158 6.5e-124 cathepsin-D [Polyrhachis vicina] 17981529 AF454831.1 494 0 AF454831 Apriona germari cathepsin D mRNA, complete cds K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 1096 4.1e-118 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF07966//PF00026 A1 Propeptide//Eukaryotic aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG1339 Aspartyl protease Cluster-8309.32423 BF_2 17.98 0.31 2710 642921119 XP_975344.2 2119 3.4e-235 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum]>gi|270006197|gb|EFA02645.1| hypothetical protein TcasGA2_TC008366 [Tribolium castaneum] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q04519 1105 5.3e-119 Sphingomyelin phosphodiesterase OS=Mus musculus GN=Smpd1 PE=2 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.32425 BF_2 403.00 68.00 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09604//PF01741 F subunit of K+-transporting ATPase (Potass_KdpF)//Large-conductance mechanosensitive channel, MscL GO:0006813//GO:0006810//GO:0043462//GO:0006811 potassium ion transport//transport//regulation of ATPase activity//ion transport GO:0008556//GO:0005216 potassium-transporting ATPase activity//ion channel activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.32426 BF_2 4010.43 41.67 4313 91094647 XP_971886.1 3678 0.0e+00 PREDICTED: protein transport protein Sec24C [Tribolium castaneum]>gi|270016466|gb|EFA12912.1| hypothetical protein TcasGA2_TC006982 [Tribolium castaneum] 751205538 XM_011178054.1 47 1.46237e-12 PREDICTED: Solenopsis invicta protein transport protein Sec24C (LOC105208248), mRNA K14007 SEC24 protein transport protein SEC24 http://www.genome.jp/dbget-bin/www_bget?ko:K14007 P53992 2462 3.8e-276 Protein transport protein Sec24C OS=Homo sapiens GN=SEC24C PE=1 SV=3 PF04811//PF04810//PF04815 Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1984 Vesicle coat complex COPII, subunit SFB3 Cluster-8309.32428 BF_2 1225.00 14.51 3820 478256803 ENN76978.1 958 2.0e-100 hypothetical protein YQE_06473, partial [Dendroctonus ponderosae]>gi|546673971|gb|ERL85479.1| hypothetical protein D910_02898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZJH7 413 1.3e-38 Protein CNPPD1 OS=Gallus gallus GN=CNPPD1 PE=2 SV=1 PF05504//PF08613 Spore germination B3/ GerAC like, C-terminal//Cyclin GO:0009847//GO:0000079 spore germination//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901 protein kinase binding GO:0016020 membrane -- -- Cluster-8309.32432 BF_2 344.00 6.87 2382 546671969 ERL84051.1 1670 3.5e-183 hypothetical protein D910_01380 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9GYU8 747 1.5e-77 Nuclear pore complex protein Nup88 OS=Drosophila melanogaster GN=mbo PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32433 BF_2 641.11 23.14 1446 817065788 XP_012254705.1 1861 1.5e-205 PREDICTED: eukaryotic initiation factor 4A-III [Athalia rosae] 642929692 XM_970418.2 426 0 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4A-III (LOC664411), mRNA K13025 EIF4A3, FAL1 ATP-dependent RNA helicase http://www.genome.jp/dbget-bin/www_bget?ko:K13025 A6M931 1772 1.3e-196 Eukaryotic initiation factor 4A-III OS=Sus scrofa GN=EIF4A3 PE=2 SV=1 PF06862//PF00270//PF04851//PF00580 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//UvrD/REP helicase N-terminal domain -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding GO:0005634 nucleus KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.32434 BF_2 66.00 16.92 450 -- -- -- -- -- 778682640 XM_004148526.2 56 1.41707e-18 PREDICTED: Cucumis sativus eukaryotic initiation factor 4A-3 (LOC101222664), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32435 BF_2 41.04 0.61 3084 642915951 XP_008190823.1 974 2.3e-102 PREDICTED: protein halfway isoform X2 [Tribolium castaneum]>gi|270004091|gb|EFA00539.1| hypothetical protein TcasGA2_TC003404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 475 6.9e-46 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32436 BF_2 2.75 0.34 623 642937505 XP_008198869.1 223 5.6e-16 PREDICTED: protein tramtrack, beta isoform-like isoform X29 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32437 BF_2 28.28 1.15 1313 642935018 XP_968403.2 1137 1.2e-121 PREDICTED: WD repeat-containing protein 91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZLL7 523 7.9e-52 WD repeat-containing protein 91 OS=Gallus gallus GN=WDR91 PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.32439 BF_2 105.90 1.23 3889 642926882 XP_008195051.1 2942 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 isoform X3 [Tribolium castaneum] 759064686 XM_011343453.1 68 2.79178e-24 PREDICTED: Cerapachys biroi probable cation-transporting ATPase 13A3 (LOC105281898), transcript variant X2, mRNA K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 1454 2.6e-159 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF00122 P5-type ATPase cation transporter//E1-E2 ATPase GO:0006812 cation transport GO:0046872//GO:0000166//GO:0016887 metal ion binding//nucleotide binding//ATPase activity GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.32441 BF_2 314.00 17.92 1020 91083327 XP_974883.1 1200 4.7e-129 PREDICTED: 39S ribosomal protein L15, mitochondrial [Tribolium castaneum]>gi|270007756|gb|EFA04204.1| hypothetical protein TcasGA2_TC014453 [Tribolium castaneum] 820844262 XM_003692379.2 89 1.51494e-36 PREDICTED: Apis florea 39S ribosomal protein L15, mitochondrial (LOC100868950), mRNA K02876 RP-L15, MRPL15, rplO large subunit ribosomal protein L15 http://www.genome.jp/dbget-bin/www_bget?ko:K02876 Q5ZKT8 755 7.7e-79 39S ribosomal protein L15, mitochondrial OS=Gallus gallus GN=MRPL15 PE=2 SV=1 -- -- GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG0846 Mitochondrial/chloroplast ribosomal protein L15/L10 Cluster-8309.32443 BF_2 263.52 13.50 1104 642912944 XP_008201318.1 277 5.4e-22 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63969 158 1.4e-09 Alpha-1-antiproteinase OS=Mus saxicola GN=Serpina1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32444 BF_2 180.25 5.73 1603 642926100 XP_008194784.1 875 3.6e-91 PREDICTED: polycomb complex protein BMI-1-A [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q91648 604 3.9e-61 Polycomb complex protein BMI-1-A OS=Xenopus laevis GN=bmi1a PE=1 SV=1 PF13639//PF03315//PF03854//PF01213//PF10099//PF03341//PF11789//PF00097//PF12678//PF14634 Ring finger domain//Serine dehydratase beta chain//P-11 zinc finger//Adenylate cyclase associated (CAP) N terminal//Anti-sigma-K factor rskA//Poxvirus mRNA capping enzyme, small subunit//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0006094//GO:0006566//GO:0006534//GO:0007010//GO:0006563//GO:0006544//GO:0006370//GO:0009451 gluconeogenesis//threonine metabolic process//cysteine metabolic process//cytoskeleton organization//L-serine metabolic process//glycine metabolic process//7-methylguanosine mRNA capping//RNA modification GO:0051539//GO:0003941//GO:0008270//GO:0003779//GO:0046872//GO:0005515//GO:0003723//GO:0004482 4 iron, 4 sulfur cluster binding//L-serine ammonia-lyase activity//zinc ion binding//actin binding//metal ion binding//protein binding//RNA binding//mRNA (guanine-N7-)-methyltransferase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2660 Locus-specific chromosome binding proteins Cluster-8309.32445 BF_2 52.74 1.67 1607 642928322 XP_008195533.1 577 1.3e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.3e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.32446 BF_2 69.69 1.83 1876 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32449 BF_2 652.34 4.16 6846 332376224 AEE63252.1 1345 4.9e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.0e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF01612//PF00930//PF00400 3'-5' exonuclease//Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006139//GO:0006508 nucleobase-containing compound metabolic process//proteolysis GO:0005515//GO:0008408//GO:0003676 protein binding//3'-5' exonuclease activity//nucleic acid binding -- -- KOG2248 3'-5' exonuclease Cluster-8309.32450 BF_2 654.29 6.41 4555 642920007 XP_975159.2 1845 3.4e-203 PREDICTED: stromal interaction molecule homolog isoform X2 [Tribolium castaneum]>gi|270005983|gb|EFA02431.1| hypothetical protein TcasGA2_TC008118 [Tribolium castaneum] -- -- -- -- -- K16059 STIM1 stromal interaction molecule 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16059 P83094 1377 2.6e-150 Stromal interaction molecule homolog OS=Drosophila melanogaster GN=Stim PE=1 SV=1 PF05478//PF02203//PF15291//PF00536//PF07647//PF05384//PF07926//PF10473 Prominin//Tar ligand binding domain homologue//Dermcidin, antibiotic peptide//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sensor protein DegS//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006935//GO:0006606//GO:0031640//GO:0007165 chemotaxis//protein import into nucleus//killing of cells of other organism//signal transduction GO:0042803//GO:0004888//GO:0005515//GO:0016301//GO:0008233//GO:0008134//GO:0045502 protein homodimerization activity//transmembrane signaling receptor activity//protein binding//kinase activity//peptidase activity//transcription factor binding//dynein binding GO:0016020//GO:0005576//GO:0030286//GO:0005667//GO:0016021 membrane//extracellular region//dynein complex//transcription factor complex//integral component of membrane KOG4403 Cell surface glycoprotein STIM, contains SAM domain Cluster-8309.32451 BF_2 619.12 6.47 4289 642920003 XP_008192163.1 334 5.2e-28 PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum]>gi|642920005|ref|XP_008192164.1| PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32452 BF_2 37.82 2.13 1030 642930199 XP_969558.2 351 1.3e-30 PREDICTED: uncharacterized protein LOC658052 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17122//PF06807 Zinc-finger//Pre-mRNA cleavage complex II protein Clp1 GO:0031124 mRNA 3'-end processing GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.32455 BF_2 49.85 2.66 1072 242117923 NP_001155992.1 154 9.7e-08 uncharacterized protein LOC100142219 [Tribolium castaneum]>gi|642936417|ref|XP_008198424.1| PREDICTED: uncharacterized protein LOC100142219 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32456 BF_2 28.58 3.13 669 642931818 XP_008196746.1 346 3.3e-30 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 282 3.6e-24 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF00958 GMP synthase C terminal domain GO:0006164//GO:0006144//GO:0006536//GO:0006177 purine nucleotide biosynthetic process//purine nucleobase metabolic process//glutamate metabolic process//GMP biosynthetic process GO:0005524//GO:0003922 ATP binding//GMP synthase (glutamine-hydrolyzing) activity -- -- KOG1622 GMP synthase Cluster-8309.32459 BF_2 654.00 7.41 3978 478257031 ENN77195.1 1576 4.6e-172 hypothetical protein YQE_06333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q08379 338 6.8e-30 Golgin subfamily A member 2 OS=Homo sapiens GN=GOLGA2 PE=1 SV=3 PF06422//PF04508//PF15070 CDR ABC transporter//Viral A-type inclusion protein repeat//Putative golgin subfamily A member 2-like protein 5 GO:0006810//GO:0016032 transport//viral process GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG4725 Uncharacterized conserved protein Cluster-8309.32461 BF_2 15.85 0.31 2447 170060164 XP_001865682.1 188 2.5e-11 galactose-specific C-type lectin [Culex quinquefasciatus]>gi|167878689|gb|EDS42072.1| galactose-specific C-type lectin [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32462 BF_2 723.31 19.74 1820 642937660 XP_008198889.1 867 3.5e-90 PREDICTED: tetraspanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17353 TSPAN18 tetraspanin-18 http://www.genome.jp/dbget-bin/www_bget?ko:K17353 Q6AYR9 287 2.6e-24 Tetraspanin-1 OS=Rattus norvegicus GN=Tspan1 PE=2 SV=1 PF01788//PF00335 PsbJ//Tetraspanin family GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020//GO:0016021 photosystem II//photosystem II reaction center//membrane//integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.32463 BF_2 154.00 2.56 2799 270012323 EFA08771.1 360 3.3e-31 hypothetical protein TcasGA2_TC006460 [Tribolium castaneum] -- -- -- -- -- K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q19529 245 2.9e-19 Probable calcium-binding mitochondrial carrier F17E5.2 OS=Caenorhabditis elegans GN=F17E5.2 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG0036 Predicted mitochondrial carrier protein Cluster-8309.32464 BF_2 93.50 2.55 1824 642923711 XP_974199.2 2254 5.1e-251 PREDICTED: protein smg8 [Tribolium castaneum] -- -- -- -- -- K18734 SMG8 protein SMG8 http://www.genome.jp/dbget-bin/www_bget?ko:K18734 B0W730 645 7.9e-66 Protein SMG8 OS=Culex quinquefasciatus GN=CPIJ003128 PE=3 SV=1 PF08653//PF10220 DASH complex subunit Dam1//Uncharacterized conserved protein (DUF2146) GO:0008608//GO:0000184 attachment of spindle microtubules to kinetochore//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex KOG3692 Uncharacterized conserved protein Cluster-8309.32466 BF_2 1329.53 67.27 1114 270297210 NP_001161910.1 1080 4.2e-115 cuticular protein analogous to peritrophins 3-A1 precursor [Tribolium castaneum]>gi|268309018|gb|ACY95475.1| cuticular protein analogous to peritrophins 3-A1 [Tribolium castaneum]>gi|270000882|gb|EEZ97329.1| hypothetical protein TcasGA2_TC011140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.32468 BF_2 1149.00 213.66 512 642929535 XP_008195878.1 435 1.2e-40 PREDICTED: cytochrome b-c1 complex subunit 7 [Tribolium castaneum]>gi|270011087|gb|EFA07535.1| hypothetical protein TcasGA2_TC009966 [Tribolium castaneum] -- -- -- -- -- K00417 QCR7, UQCRB ubiquinol-cytochrome c reductase subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K00417 Q5RC24 317 2.4e-28 Cytochrome b-c1 complex subunit 7 OS=Pongo abelii GN=UQCRB PE=3 SV=3 PF02271 Ubiquinol-cytochrome C reductase complex 14kD subunit GO:0006122//GO:0006118//GO:0015992//GO:0006119 mitochondrial electron transport, ubiquinol to cytochrome c//obsolete electron transport//proton transport//oxidative phosphorylation GO:0008121 ubiquinol-cytochrome-c reductase activity GO:0005750 mitochondrial respiratory chain complex III KOG3440 Ubiquinol cytochrome c reductase, subunit QCR7 Cluster-8309.32469 BF_2 87.71 1.15 3478 91088287 XP_968620.1 2906 0.0e+00 PREDICTED: succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial isoform X1 [Tribolium castaneum]>gi|270012778|gb|EFA09226.1| hypothetical protein TcasGA2_TC006271 [Tribolium castaneum] 830244945 XM_012734906.1 514 0 PREDICTED: Condylura cristata succinate dehydrogenase complex, subunit A, flavoprotein (Fp) (SDHA), mRNA K00234 SDHA, SDH1 succinate dehydrogenase (ubiquinone) flavoprotein subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00234 Q9YHT1 2618 2.5e-294 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial OS=Gallus gallus GN=SDHA PE=1 SV=2 PF07992//PF01266//PF01494//PF02910//PF01134 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//FAD binding domain//Fumarate reductase flavoprotein C-term//Glucose inhibited division protein A GO:0008033//GO:0055114//GO:0006099//GO:0022900 tRNA processing//oxidation-reduction process//tricarboxylic acid cycle//electron transport chain GO:0016627//GO:0050660//GO:0016491//GO:0071949 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity//FAD binding -- -- KOG2403 Succinate dehydrogenase, flavoprotein subunit Cluster-8309.32470 BF_2 422.47 9.97 2059 642915063 XP_008190394.1 1382 7.5e-150 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 631 3.7e-64 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF00441//PF02771//PF02770//PF09057 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Second Mitochondria-derived Activator of Caspases GO:0008152//GO:0055114//GO:0006915//GO:0006919//GO:0006118 metabolic process//oxidation-reduction process//apoptotic process//activation of cysteine-type endopeptidase activity involved in apoptotic process//obsolete electron transport GO:0003995//GO:0016627//GO:0050660 acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding GO:0005739 mitochondrion KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.32471 BF_2 1167.00 9.65 5348 91079092 XP_975294.1 3398 0.0e+00 PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916387|ref|XP_008191000.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916389|ref|XP_008191001.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916391|ref|XP_008191002.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|642916393|ref|XP_008191003.1| PREDICTED: irregular chiasm C-roughest protein isoform X1 [Tribolium castaneum]>gi|270003651|gb|EFA00099.1| hypothetical protein TcasGA2_TC002914 [Tribolium castaneum] 642916394 XM_970201.3 683 0 PREDICTED: Tribolium castaneum irregular chiasm C-roughest protein (LOC664188), transcript variant X5, mRNA -- -- -- -- Q08180 1769 1.1e-195 Irregular chiasm C-roughest protein OS=Drosophila melanogaster GN=rst PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.32472 BF_2 12899.49 384.66 1690 332375414 AEE62848.1 1924 8.7e-213 unknown [Dendroctonus ponderosae]>gi|478252245|gb|ENN72673.1| hypothetical protein YQE_10771, partial [Dendroctonus ponderosae]>gi|546675733|gb|ERL86865.1| hypothetical protein D910_04268 [Dendroctonus ponderosae] 751469686 XM_011191737.1 379 0 PREDICTED: Bactrocera cucurbitae enolase (LOC105216959), mRNA K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 P15007 1744 2.7e-193 Enolase OS=Drosophila melanogaster GN=Eno PE=1 SV=2 PF00113//PF03952//PF00817 Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain//impB/mucB/samB family GO:0006096//GO:0006281//GO:0006094//GO:0009094//GO:0000162//GO:0006571 glycolytic process//DNA repair//gluconeogenesis//L-phenylalanine biosynthetic process//tryptophan biosynthetic process//tyrosine biosynthetic process GO:0004634//GO:0000287 phosphopyruvate hydratase activity//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-8309.32475 BF_2 9.01 0.31 1489 861652644 KMQ98436.1 372 7.1e-33 60s ribosomal protein l3 [Lasius niger] 268306351 GU084264.1 102 1.32522e-43 Manduca sexta ribosomal protein L3 (rpl3) mRNA, complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 359 9.4e-33 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF10389//PF00297 Bacteriophage coat protein B//Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0019028 intracellular//ribosome//viral capsid KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.32476 BF_2 64.44 0.73 3999 646696398 KDR08721.1 1292 4.0e-139 Nucleolar protein 14 [Zootermopsis nevadensis] -- -- -- -- -- K14766 NOP14, UTP2 nucleolar protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K14766 Q9VEJ2 921 1.7e-97 Nucleolar protein 14 homolog OS=Drosophila melanogaster GN=l(3)07882 PE=2 SV=2 PF15549//PF04147//PF05859//PF08361 PGC7/Stella/Dppa3 domain//Nop14-like family//Mis12 protein//MAATS-type transcriptional repressor, C-terminal region GO:0007067//GO:0007049 mitotic nuclear division//cell cycle GO:0003677//GO:0035064 DNA binding//methylated histone binding GO:0005634//GO:0000775//GO:0032040 nucleus//chromosome, centromeric region//small-subunit processome KOG2147 Nucleolar protein involved in 40S ribosome biogenesis Cluster-8309.32477 BF_2 459.00 13.70 1689 91092926 XP_971772.1 204 2.4e-13 PREDICTED: brain protein I3 [Tribolium castaneum]>gi|270003102|gb|EEZ99549.1| hypothetical protein TcasGA2_TC000131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28662 128 6.5e-06 Brain protein I3 OS=Mus musculus GN=Bri3 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32478 BF_2 322.00 13.37 1295 332375134 AEE62708.1 547 3.1e-53 unknown [Dendroctonus ponderosae]>gi|478270808|gb|ENN83562.1| hypothetical protein YQE_00085, partial [Dendroctonus ponderosae]>gi|546673460|gb|ERL85058.1| hypothetical protein D910_02481 [Dendroctonus ponderosae] 805798271 XM_012288404.1 100 1.48555e-42 PREDICTED: Megachile rotundata dynein light chain Tctex-type 1 (LOC100879789), transcript variant X2, mRNA K10420 DYNLT dynein light chain Tctex-type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10420 Q94524 440 3.3e-42 Dynein light chain Tctex-type OS=Drosophila melanogaster GN=Dlc90F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4081 Dynein light chain Cluster-8309.32479 BF_2 499.67 4.86 4584 642923911 XP_008193924.1 2383 1.4e-265 PREDICTED: nucleolar protein 10 [Tribolium castaneum]>gi|270007790|gb|EFA04238.1| hypothetical protein TcasGA2_TC014492 [Tribolium castaneum] 817185075 XM_012429433.1 102 4.14388e-43 PREDICTED: Orussus abietinus nucleolar protein 10 (LOC105702116), transcript variant X1, mRNA K14788 NOL10, ENP2 ribosome biogenesis protein ENP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14788 Q7T0Q5 1808 2.7e-200 Nucleolar protein 10 OS=Xenopus laevis GN=nol10 PE=2 SV=1 PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus KOG2321 WD40 repeat protein Cluster-8309.32481 BF_2 363.10 9.42 1900 642919169 XP_008191766.1 1427 4.2e-155 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q810J8 982 6.9e-105 Zinc finger FYVE domain-containing protein 1 OS=Mus musculus GN=Zfyve1 PE=2 SV=2 PF02263//PF04548//PF01926 Guanylate-binding protein, N-terminal domain//AIG1 family//50S ribosome-binding GTPase -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- -- -- Cluster-8309.32482 BF_2 709.93 27.89 1352 642919171 XP_967331.2 660 2.6e-66 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q5RFL4 488 9.3e-48 Zinc finger FYVE domain-containing protein 1 OS=Pongo abelii GN=ZFYVE1 PE=2 SV=1 PF01667//PF01363//PF08782//PF12678 Ribosomal protein S27//FYVE zinc finger//c-SKI Smad4 binding domain//RING-H2 zinc finger GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008270//GO:0003735//GO:0046332//GO:0046872 zinc ion binding//structural constituent of ribosome//SMAD binding//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.32483 BF_2 132.00 2.31 2679 478254828 ENN75064.1 3423 0.0e+00 hypothetical protein YQE_08377, partial [Dendroctonus ponderosae] 195469995 XM_002099885.1 153 1.07384e-71 Drosophila yakuba GE16763 (Dyak\GE16763), partial mRNA K02542 MCM6 DNA replication licensing factor MCM6 http://www.genome.jp/dbget-bin/www_bget?ko:K02542 Q29JI9 2972 0.0e+00 DNA replication licensing factor Mcm6 OS=Drosophila pseudoobscura pseudoobscura GN=Mcm6 PE=3 SV=1 PF07726//PF07728//PF00158//PF00493//PF05184 ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//MCM2/3/5 family//Saposin-like type B, region 1 GO:0006260//GO:0006355//GO:0006629 DNA replication//regulation of transcription, DNA-templated//lipid metabolic process GO:0016887//GO:0003677//GO:0005524//GO:0008134 ATPase activity//DNA binding//ATP binding//transcription factor binding GO:0005667 transcription factor complex KOG0480 DNA replication licensing factor, MCM6 component Cluster-8309.32484 BF_2 3.08 0.48 558 91080821 XP_966682.1 208 2.7e-14 PREDICTED: uncharacterized protein LOC658984 [Tribolium castaneum]>gi|270005906|gb|EFA02354.1| hypothetical protein TcasGA2_TC008024 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32485 BF_2 1049.26 9.42 4949 642930728 XP_008200003.1 1770 1.8e-194 PREDICTED: sorting nexin-8 [Tribolium castaneum] -- -- -- -- -- K17922 SNX8, MVP1 sorting nexin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K17922 Q2KHV6 733 1.3e-75 Sorting nexin-8 OS=Bos taurus GN=SNX8 PE=2 SV=1 PF00107//PF00787//PF01118 Zinc-binding dehydrogenase//PX domain//Semialdehyde dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620//GO:0035091//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//phosphatidylinositol binding//NAD binding -- -- KOG1196 Predicted NAD-dependent oxidoreductase Cluster-8309.32486 BF_2 437.37 7.79 2635 642918946 XP_008191669.1 594 2.3e-58 PREDICTED: transcriptional regulator ATRX homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0006468//GO:0009069//GO:0016310//GO:0007165 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//signal transduction GO:0004674//GO:0005096 protein serine/threonine kinase activity//GTPase activator activity -- -- -- -- Cluster-8309.32488 BF_2 889.53 9.72 4117 642925010 XP_008194133.1 4674 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X3 [Tribolium castaneum] 759033712 XM_011331767.1 146 1.29089e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X1, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3842 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF15014//PF03485//PF05236//PF03540//PF03293 Ceroid-lipofuscinosis neuronal protein 5//Arginyl tRNA synthetase N terminal domain//Transcription initiation factor TFIID component TAF4 family//Transcription initiation factor TFIID 23-30kDa subunit//Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0019083//GO:0006525//GO:0022008//GO:0006420//GO:0006351//GO:0006560//GO:0006144//GO:0006206//GO:0006352 viral transcription//arginine metabolic process//neurogenesis//arginyl-tRNA aminoacylation//transcription, DNA-templated//proline metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation GO:0003899//GO:0005524//GO:0000166//GO:0003677//GO:0004814 DNA-directed RNA polymerase activity//ATP binding//nucleotide binding//DNA binding//arginine-tRNA ligase activity GO:0005764//GO:0005737//GO:0005730//GO:0005669//GO:0005634 lysosome//cytoplasm//nucleolus//transcription factor TFIID complex//nucleus KOG3635 Phosphorylase kinase Cluster-8309.32490 BF_2 283.08 0.94 12890 255522799 NP_001157312.1 417 3.7e-37 longitudinals lacking isoform 3 [Tribolium castaneum] 805821658 XM_012295481.1 73 1.54691e-26 PREDICTED: Megachile rotundata zinc finger protein OZF-like (LOC105663827), mRNA -- -- -- -- Q7KQZ4 215 4.0e-15 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF02176//PF00096//PF13465//PF04988 TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.32492 BF_2 468.00 3.04 6724 478259590 ENN79443.1 1869 8.3e-206 hypothetical protein YQE_04087, partial [Dendroctonus ponderosae] 471223427 XM_004030445.1 37 8.2791e-07 Ichthyophthirius multifiliis hypothetical protein (IMG5_159830) mRNA, complete cds K10901 BLM, RECQL3, SGS1 bloom syndrome protein http://www.genome.jp/dbget-bin/www_bget?ko:K10901 Q9VGI8 1306 6.5e-142 Bloom syndrome protein homolog OS=Drosophila melanogaster GN=Blm PE=1 SV=1 PF00270//PF00570//PF09382//PF08503//PF00069//PF07714//PF04851 DEAD/DEAH box helicase//HRDC domain//RQC domain//Tetrahydrodipicolinate succinyltransferase N-terminal//Protein kinase domain//Protein tyrosine kinase//Type III restriction enzyme, res subunit GO:0006281//GO:0042967//GO:0006531//GO:0006468//GO:0006260//GO:0006522 DNA repair//acyl-carrier-protein biosynthetic process//aspartate metabolic process//protein phosphorylation//DNA replication//alanine metabolic process GO:0003677//GO:0016787//GO:0047200//GO:0005524//GO:0003676//GO:0004672//GO:0043140 DNA binding//hydrolase activity//tetrahydrodipicolinate N-acetyltransferase activity//ATP binding//nucleic acid binding//protein kinase activity//ATP-dependent 3'-5' DNA helicase activity GO:0005657//GO:0005622 replication fork//intracellular KOG0351 ATP-dependent DNA helicase Cluster-8309.32493 BF_2 1165.15 11.06 4693 642920083 XP_008192197.1 1427 1.0e-154 PREDICTED: glycogen synthase kinase-3 beta isoform X2 [Tribolium castaneum] 642920086 XM_008193977.1 296 6.07698e-151 PREDICTED: Tribolium castaneum shaggy (LOC664299), transcript variant X4, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 1208 1.1e-130 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF06293//PF00069//PF07714//PF14552 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Tautomerase enzyme GO:0006725//GO:0006468 cellular aromatic compound metabolic process//protein phosphorylation GO:0004672//GO:0016853//GO:0005524//GO:0016773 protein kinase activity//isomerase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0658 Glycogen synthase kinase-3 Cluster-8309.32494 BF_2 1327.67 22.45 2761 91083595 XP_968896.1 1885 4.7e-208 PREDICTED: autophagy-related protein 9A [Tribolium castaneum]>gi|270006840|gb|EFA03288.1| hypothetical protein TcasGA2_TC013228 [Tribolium castaneum] 642924119 XM_963803.2 67 7.10144e-24 PREDICTED: Tribolium castaneum autophagy-related protein 9A (LOC657338), mRNA K17907 ATG9 autophagy-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K17907 Q3T904 1464 1.3e-160 Autophagy-related protein 9A OS=Bos taurus GN=ATG9A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2173 Integral membrane protein Cluster-8309.32495 BF_2 82.00 19.37 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32496 BF_2 144.15 4.48 1634 642915402 XP_008190599.1 1563 6.1e-171 PREDICTED: nocturnin isoform X1 [Tribolium castaneum] -- -- -- -- -- K18764 CCRN4L nocturnin http://www.genome.jp/dbget-bin/www_bget?ko:K18764 Q9UK39 750 4.7e-78 Nocturnin OS=Homo sapiens GN=CCRN4L PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.32498 BF_2 688.56 25.07 1436 91081785 XP_973657.1 1265 1.9e-136 PREDICTED: putative E3 ubiquitin-protein ligase UBR7 [Tribolium castaneum]>gi|270005043|gb|EFA01491.1| hypothetical protein TcasGA2_TC007045 [Tribolium castaneum] -- -- -- -- -- K11979 UBR7 E3 ubiquitin-protein ligase UBR7 http://www.genome.jp/dbget-bin/www_bget?ko:K11979 Q8BU04 682 3.2e-70 Putative E3 ubiquitin-protein ligase UBR7 OS=Mus musculus GN=Ubr7 PE=1 SV=1 PF02207//PF00628 Putative zinc finger in N-recognin (UBR box)//PHD-finger GO:0016567 protein ubiquitination GO:0008270//GO:0005515//GO:0046872//GO:0004842 zinc ion binding//protein binding//metal ion binding//ubiquitin-protein transferase activity -- -- KOG2752 Uncharacterized conserved protein, contains N-recognin-type Zn-finger Cluster-8309.32499 BF_2 9.21 0.37 1333 642925292 XP_001814214.2 352 1.3e-30 PREDICTED: uncharacterized protein LOC100142468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32500 BF_2 500.05 10.51 2277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32502 BF_2 436.08 34.50 816 642937737 XP_008198926.1 722 1.0e-73 PREDICTED: tropomyosin-1, isoforms 9A/A/B isoform X19 [Tribolium castaneum] 780660612 XM_011694428.1 172 8.71527e-83 PREDICTED: Wasmannia auropunctata tropomyosin (LOC105452880), transcript variant X18, mRNA K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 P06754 566 5.1e-57 Tropomyosin-1, isoforms 9A/A/B OS=Drosophila melanogaster GN=Tm1 PE=2 SV=2 PF06009//PF02185//PF14073//PF02601//PF16716//PF00769//PF10186 Laminin Domain II//Hr1 repeat//Centrosome localisation domain of Cep57//Exonuclease VII, large subunit//Bone marrow stromal antigen 2//Ezrin/radixin/moesin family//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006308//GO:0010508//GO:0007155//GO:0051607//GO:0007165 DNA catabolic process//positive regulation of autophagy//cell adhesion//defense response to virus//signal transduction GO:0043015//GO:0008855//GO:0008092//GO:0042802 gamma-tubulin binding//exodeoxyribonuclease VII activity//cytoskeletal protein binding//identical protein binding GO:0005737//GO:0009318//GO:0045298//GO:0019898 cytoplasm//exodeoxyribonuclease VII complex//tubulin complex//extrinsic component of membrane KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.32503 BF_2 674.65 10.16 3066 642932293 XP_008197052.1 806 6.9e-83 PREDICTED: epidermal growth factor-like protein 8 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9Y5W5 249 1.1e-19 Wnt inhibitory factor 1 OS=Homo sapiens GN=WIF1 PE=1 SV=3 PF11698//PF05531//PF16326//PF07645//PF00008 V-ATPase subunit H//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Calcium-binding EGF domain//EGF-like domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820//GO:0005515//GO:0005509//GO:0003677 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//calcium ion binding//DNA binding GO:0000221//GO:0019028 vacuolar proton-transporting V-type ATPase, V1 domain//viral capsid KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.32505 BF_2 597.83 5.19 5107 270004497 EFA00945.1 2146 4.8e-238 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q69ZS7 1399 8.2e-153 HBS1-like protein OS=Mus musculus GN=Hbs1l PE=1 SV=2 PF01926//PF05773//PF03144//PF13495 50S ribosome-binding GTPase//RWD domain//Elongation factor Tu domain 2//Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677//GO:0005525//GO:0005515 DNA binding//GTP binding//protein binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.32507 BF_2 395.49 7.01 2646 91088147 XP_971356.1 1186 5.1e-127 PREDICTED: platelet-activating factor acetylhydrolase [Tribolium castaneum]>gi|270012120|gb|EFA08568.1| hypothetical protein TcasGA2_TC006223 [Tribolium castaneum] -- -- -- -- -- K05961 dnk deoxynucleoside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05961 P70683 536 5.0e-53 Platelet-activating factor acetylhydrolase OS=Cavia porcellus GN=PLA2G7 PE=2 SV=1 PF03403//PF00005//PF01121//PF02367 Platelet-activating factor acetylhydrolase, isoform II//ABC transporter//Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0016042//GO:0002949//GO:0046486//GO:0015937//GO:0015940 lipid catabolic process//tRNA threonylcarbamoyladenosine modification//glycerolipid metabolic process//coenzyme A biosynthetic process//pantothenate biosynthetic process GO:0016887//GO:0004140//GO:0003847//GO:0005524 ATPase activity//dephospho-CoA kinase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//ATP binding GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4235 Mitochondrial thymidine kinase 2/deoxyguanosine kinase Cluster-8309.32508 BF_2 69.95 1.81 1902 270010983 EFA07431.1 1357 5.5e-147 cactin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUQ7 873 3.0e-92 Cactin OS=Homo sapiens GN=CACTIN PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2370 Cactin Cluster-8309.32511 BF_2 948.00 74.71 818 478253481 ENN73808.1 879 6.3e-92 hypothetical protein YQE_09586, partial [Dendroctonus ponderosae]>gi|546679135|gb|ERL89640.1| hypothetical protein D910_07005 [Dendroctonus ponderosae] -- -- -- -- -- K13280 SEC11, sipW signal peptidase, endoplasmic reticulum-type http://www.genome.jp/dbget-bin/www_bget?ko:K13280 Q5R9C7 750 2.4e-78 Signal peptidase complex catalytic subunit SEC11A OS=Pongo abelii GN=SEC11A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3342 Signal peptidase I Cluster-8309.32512 BF_2 895.44 6.52 6033 91093431 XP_969079.1 1185 1.5e-126 PREDICTED: AMMECR1-like protein [Tribolium castaneum]>gi|270015455|gb|EFA11903.1| hypothetical protein TcasGA2_TC004060 [Tribolium castaneum] 880861289 XM_005065312.2 74 2.00741e-27 PREDICTED: Mesocricetus auratus AMMECR1-like (Ammecr1l), transcript variant X3, mRNA -- -- -- -- Q5RAS7 774 2.9e-80 AMME syndrome candidate gene 1 protein homolog OS=Pongo abelii GN=AMMECR1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3274 Uncharacterized conserved protein, AMMECR1 Cluster-8309.32515 BF_2 41.00 0.38 4818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32516 BF_2 190.95 8.25 1255 820836809 XP_012347035.1 266 1.2e-20 PREDICTED: multiple coagulation factor deficiency protein 2 homolog [Apis florea] 820836808 XM_012491581.1 84 1.12779e-33 PREDICTED: Apis florea multiple coagulation factor deficiency protein 2 homolog (LOC100872590), mRNA -- -- -- -- Q8NI22 133 1.3e-06 Multiple coagulation factor deficiency protein 2 OS=Homo sapiens GN=MCFD2 PE=1 SV=1 PF03133//PF13405//PF00036//PF13499 Tubulin-tyrosine ligase family//EF-hand domain//EF hand//EF-hand domain pair GO:0006464 cellular protein modification process GO:0005509 calcium ion binding -- -- KOG4065 Uncharacterized conserved protein Cluster-8309.32517 BF_2 3.00 0.57 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32519 BF_2 262.62 6.21 2055 91089555 XP_971709.1 365 6.3e-32 PREDICTED: uncharacterized protein LOC660380 [Tribolium castaneum]>gi|270011380|gb|EFA07828.1| hypothetical protein TcasGA2_TC005397 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32520 BF_2 103.85 2.62 1945 91083175 XP_972331.1 975 1.1e-102 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 633 2.1e-64 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 PF15182 Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.32521 BF_2 383.89 2.38 7043 91087491 XP_968373.1 1498 9.1e-163 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 1.43108e-14 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1147 1.9e-123 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF02803//PF00108//PF05699 Thiolase, C-terminal domain//Thiolase, N-terminal domain//hAT family C-terminal dimerisation region GO:0008152 metabolic process GO:0016747//GO:0046983 transferase activity, transferring acyl groups other than amino-acyl groups//protein dimerization activity -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.32522 BF_2 254.73 5.15 2355 642916843 XP_008199526.1 1297 6.1e-140 PREDICTED: N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 [Tribolium castaneum]>gi|270003073|gb|EEZ99520.1| hypothetical protein TcasGA2_TC000101 [Tribolium castaneum] 642916842 XM_008201304.1 269 3.09331e-136 PREDICTED: Tribolium castaneum N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (LOC656887), mRNA K01482 DDAH, ddaH dimethylargininase http://www.genome.jp/dbget-bin/www_bget?ko:K01482 O94760 569 6.6e-57 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 OS=Homo sapiens GN=DDAH1 PE=1 SV=3 PF03808 Glycosyl transferase WecB/TagA/CpsF family GO:0006807//GO:0009058 nitrogen compound metabolic process//biosynthetic process GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0005737 cytoplasm -- -- Cluster-8309.32525 BF_2 592.00 266.21 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32526 BF_2 797.65 90.71 655 478251510 ENN71973.1 414 4.2e-38 hypothetical protein YQE_11406, partial [Dendroctonus ponderosae]>gi|546670932|gb|ERL83482.1| hypothetical protein D910_00493 [Dendroctonus ponderosae]>gi|546672184|gb|ERL84166.1| hypothetical protein D910_01539 [Dendroctonus ponderosae]>gi|546673231|gb|ERL84880.1| hypothetical protein D910_02303 [Dendroctonus ponderosae]>gi|546679973|gb|ERL90339.1| hypothetical protein D910_07688 [Dendroctonus ponderosae] -- -- -- -- -- K04078 groES, HSPE1 chaperonin GroES http://www.genome.jp/dbget-bin/www_bget?ko:K04078 Q5DC69 321 1.0e-28 10 kDa heat shock protein, mitochondrial OS=Schistosoma japonicum GN=SJCHGC01960 PE=3 SV=2 PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm KOG1641 Mitochondrial chaperonin Cluster-8309.32529 BF_2 22.40 0.41 2592 642927860 XP_008195428.1 1738 4.9e-191 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X1 [Tribolium castaneum] 662183442 XM_008489250.1 116 3.84501e-51 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA K13297 PTPRT receptor-type tyrosine-protein phosphatase T http://www.genome.jp/dbget-bin/www_bget?ko:K13297 Q99M80 837 6.1e-88 Receptor-type tyrosine-protein phosphatase T OS=Mus musculus GN=Ptprt PE=2 SV=2 PF00102 Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725 protein tyrosine phosphatase activity -- -- KOG4228 Protein tyrosine phosphatase Cluster-8309.32530 BF_2 26.00 0.66 1929 557765835 XP_005182615.1 1540 3.3e-168 PREDICTED: fructose-bisphosphate aldolase isoform X2 [Musca domestica]>gi|755904857|ref|XP_011295962.1| PREDICTED: fructose-bisphosphate aldolase isoform X2 [Musca domestica] 659114129 KJ686589.1 557 0 Fenneropenaeus chinensis fructose 1,6-biphosphate-aldolase A mRNA, complete cds K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P05065 1259 5.3e-137 Fructose-bisphosphate aldolase A OS=Rattus norvegicus GN=Aldoa PE=1 SV=2 PF01545//PF00274 Cation efflux family//Fructose-bisphosphate aldolase class-I GO:0006020//GO:0006096//GO:0006098//GO:0055085//GO:0006013//GO:0006000//GO:0006812//GO:0006094//GO:0015976 inositol metabolic process//glycolytic process//pentose-phosphate shunt//transmembrane transport//mannose metabolic process//fructose metabolic process//cation transport//gluconeogenesis//carbon utilization GO:0004332//GO:0008324 fructose-bisphosphate aldolase activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1557 Fructose-biphosphate aldolase Cluster-8309.32531 BF_2 1385.54 7.12 8425 820805550 AKG92766.1 2666 4.0e-298 Mlx interactor [Leptinotarsa decemlineata] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 Q9HAP2 562 1.5e-55 MLX-interacting protein OS=Homo sapiens GN=MLXIP PE=1 SV=2 PF13180//PF00595//PF00010//PF06005 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Helix-loop-helix DNA-binding domain//Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly GO:0046983//GO:0005515 protein dimerization activity//protein binding GO:0005737 cytoplasm KOG3582 Mlx interactors and related transcription factors Cluster-8309.32534 BF_2 369.99 43.62 642 646705170 KDR13037.1 288 1.7e-23 hypothetical protein L798_13305 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W3T5 273 3.8e-23 Small integral membrane protein 4 OS=Drosophila melanogaster GN=CG32736 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32538 BF_2 2248.60 34.11 3045 189236779 XP_967166.2 953 6.2e-100 PREDICTED: reticulon-1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 482 1.0e-46 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF01442//PF00834 Apolipoprotein A1/A4/E domain//Ribulose-phosphate 3 epimerase family GO:0006869//GO:0005975//GO:0042157 lipid transport//carbohydrate metabolic process//lipoprotein metabolic process GO:0008289//GO:0016857 lipid binding//racemase and epimerase activity, acting on carbohydrates and derivatives GO:0005576 extracellular region KOG1792 Reticulon Cluster-8309.32539 BF_2 184.77 3.60 2432 546683583 ERL93378.1 1257 2.8e-135 hypothetical protein D910_10670 [Dendroctonus ponderosae] 631238985 XM_007916224.1 78 4.79643e-30 Togninia minima UCRPA7 putative casein kinase ii subunit alpha protein mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 P21868 991 7.9e-106 Casein kinase II subunit alpha OS=Gallus gallus GN=CSNK2A1 PE=2 SV=1 PF00075//PF06293//PF00069//PF07714 RNase H//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0051252//GO:0006468 regulation of RNA metabolic process//protein phosphorylation GO:0004523//GO:0004672//GO:0016773//GO:0003676//GO:0005524 RNA-DNA hybrid ribonuclease activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//nucleic acid binding//ATP binding GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.32540 BF_2 41.03 0.48 3880 642930226 XP_008196308.1 864 1.6e-89 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 333 2.5e-29 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- KOG1250 Threonine/serine dehydratases Cluster-8309.32541 BF_2 269.44 7.72 1747 642930226 XP_008196308.1 1679 2.3e-184 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 606 2.5e-61 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- KOG1250 Threonine/serine dehydratases Cluster-8309.32542 BF_2 820.00 35.08 1265 91085651 XP_970979.1 693 3.6e-70 PREDICTED: ER membrane protein complex subunit 7 homolog [Tribolium castaneum]>gi|270010092|gb|EFA06540.1| hypothetical protein TcasGA2_TC009444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R5V2 373 1.9e-34 ER membrane protein complex subunit 7 OS=Macaca fascicularis GN=EMC7 PE=2 SV=1 PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region KOG3306 Predicted membrane protein Cluster-8309.32543 BF_2 119.38 2.00 2784 478256531 ENN76715.1 706 2.5e-71 hypothetical protein YQE_06780, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R8X1 405 8.1e-38 Zinc finger protein 665 OS=Pongo abelii GN=ZNF665 PE=2 SV=1 PF16622//PF13912//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.32546 BF_2 43.87 0.61 3313 147902182 NP_001079763.1 447 3.2e-41 ER lumen protein-retaining receptor 3 [Xenopus laevis]>gi|6685399|sp|O42580.1|ERD23_XENLA RecName: Full=ER lumen protein-retaining receptor 3; AltName: Full=KDEL endoplasmic reticulum protein retention receptor 3; Short=KDEL receptor 3 [Xenopus laevis]>gi|2467290|emb|CAA04817.1| KDEL receptor [Xenopus laevis]>gi|32450093|gb|AAH54181.1| MGC64313 protein [Xenopus laevis] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 Q66JF2 456 1.2e-43 ER lumen protein-retaining receptor 3 OS=Xenopus tropicalis GN=kdelr3 PE=2 SV=1 PF15050//PF05297//PF00810 SCIMP protein//Herpesvirus latent membrane protein 1 (LMP1)//ER lumen protein retaining receptor GO:0019087//GO:0006621 transformation of host cell by virus//protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0097197//GO:0005783//GO:0001772//GO:0016021 tetraspanin-enriched microdomain//endoplasmic reticulum//immunological synapse//integral component of membrane KOG3106 ER lumen protein retaining receptor Cluster-8309.32547 BF_2 1.00 0.51 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32548 BF_2 13.44 0.40 1693 642928387 XP_008192723.1 425 5.8e-39 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00658 DLST, sucB 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00658 P36957 267 5.0e-22 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial OS=Homo sapiens GN=DLST PE=1 SV=4 PF01213//PF07831 Adenylate cyclase associated (CAP) N terminal//Pyrimidine nucleoside phosphorylase C-terminal domain GO:0007010//GO:0006213 cytoskeleton organization//pyrimidine nucleoside metabolic process GO:0016763//GO:0003779 transferase activity, transferring pentosyl groups//actin binding -- -- KOG0559 Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) Cluster-8309.32549 BF_2 149.22 1.46 4564 91091214 XP_966756.1 1621 3.2e-177 PREDICTED: WD repeat-containing protein 24 [Tribolium castaneum]>gi|270014105|gb|EFA10553.1| hypothetical protein TcasGA2_TC012809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZX22 770 6.3e-80 WD repeat-containing protein 24 OS=Xenopus laevis GN=wdr24 PE=2 SV=1 PF00628//PF00400 PHD-finger//WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0269 WD40 repeat-containing protein Cluster-8309.32550 BF_2 115.17 3.65 1606 91079260 XP_971902.1 1542 1.6e-168 PREDICTED: N-acetylgalactosamine kinase [Tribolium castaneum]>gi|270004305|gb|EFA00753.1| hypothetical protein TcasGA2_TC003637 [Tribolium castaneum] -- -- -- -- -- K18674 GALK2 N-acetylgalactosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K18674 Q68FH4 976 2.9e-104 N-acetylgalactosamine kinase OS=Mus musculus GN=Galk2 PE=1 SV=1 PF00288 GHMP kinases N terminal domain GO:0046835//GO:0006012 carbohydrate phosphorylation//galactose metabolic process GO:0005524//GO:0004335 ATP binding//galactokinase activity GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.32551 BF_2 17.27 0.39 2137 642918890 XP_973456.3 989 2.9e-104 PREDICTED: persulfide dioxygenase ETHE1, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17725 ETHE1 sulfur dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K17725 Q9DCM0 746 1.8e-77 Persulfide dioxygenase ETHE1, mitochondrial OS=Mus musculus GN=Ethe1 PE=1 SV=2 PF15221 Lens epithelial cell protein LEP503 GO:0007275 multicellular organismal development -- -- -- -- KOG0813 Glyoxylase Cluster-8309.32552 BF_2 1611.82 79.15 1139 642922873 XP_008200433.1 1743 5.7e-192 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A [Tribolium castaneum]>gi|270006562|gb|EFA03010.1| hypothetical protein TcasGA2_TC010433 [Tribolium castaneum] 195346084 XM_002039563.1 309 8.56162e-159 Drosophila sechellia GM22642 (Dsec\GM22642), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q5RCE2 1485 1.9e-163 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A OS=Pongo abelii GN=STT3A PE=2 SV=1 PF10034//PF02516 Q-cell neuroblast polarisation//Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016021//GO:0016020//GO:0008250 integral component of membrane//membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.32553 BF_2 1035.56 26.15 1944 478251087 ENN71563.1 634 3.8e-63 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.4e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF08465//PF07685 Thymidine kinase from Herpesvirus C-terminal//CobB/CobQ-like glutamine amidotransferase domain GO:0006230//GO:0006206//GO:0009236 TMP biosynthetic process//pyrimidine nucleobase metabolic process//cobalamin biosynthetic process GO:0004797//GO:0003824//GO:0005524 thymidine kinase activity//catalytic activity//ATP binding -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.32554 BF_2 21.63 0.39 2589 91081127 XP_976484.1 546 8.2e-53 PREDICTED: protein maelstrom [Tribolium castaneum]>gi|270006444|gb|EFA02892.1| maelstrom [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0W2W6 332 2.2e-29 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.32556 BF_2 54.00 8.10 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32557 BF_2 365.41 13.03 1460 642922684 XP_008193279.1 482 1.2e-45 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X11 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 224 4.1e-17 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF10717//PF00057 Occlusion-derived virus envelope protein ODV-E18//Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.32559 BF_2 67.95 1.24 2574 642918045 XP_008198993.1 330 9.1e-28 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5PK40 259 6.4e-21 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.32560 BF_2 81.87 5.12 956 546672885 ERL84608.1 427 1.9e-39 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 Q71SP7 341 7.3e-31 Fatty acid synthase OS=Bos taurus GN=FASN PE=2 SV=1 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.32561 BF_2 33.49 0.52 3006 768418017 XP_011549676.1 411 4.3e-37 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial isoform X5 [Plutella xylostella] 768418016 XM_011551374.1 83 9.87155e-33 PREDICTED: Plutella xylostella probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial (LOC105381602), transcript variant X5, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 392 2.8e-36 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF02771 Acyl-CoA dehydrogenase, N-terminal domain GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050660//GO:0016627 flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.32564 BF_2 106.23 2.10 2405 478253016 ENN73396.1 2434 9.0e-272 hypothetical protein YQE_09958, partial [Dendroctonus ponderosae] 346709294 AK382373.1 419 0 Bombyx mori mRNA, clone: fdpe16B03 K11968 ARIH1 ariadne-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11968 Q94981 1973 1.1e-219 Protein ariadne-1 OS=Drosophila melanogaster GN=ari-1 PE=1 SV=2 PF14634//PF17123//PF00097//PF13639 zinc-RING finger domain//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.32565 BF_2 193.77 3.76 2444 478253016 ENN73396.1 2434 9.2e-272 hypothetical protein YQE_09958, partial [Dendroctonus ponderosae] 346709294 AK382373.1 419 0 Bombyx mori mRNA, clone: fdpe16B03 K11968 ARIH1 ariadne-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11968 Q94981 1973 1.1e-219 Protein ariadne-1 OS=Drosophila melanogaster GN=ari-1 PE=1 SV=2 PF00097//PF17123//PF14634//PF13639 Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//zinc-RING finger domain//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.32566 BF_2 65.19 1.17 2625 332376294 AEE63287.1 1800 3.2e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 8.85839e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 5.6e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.32567 BF_2 553.67 9.23 2796 332376294 AEE63287.1 1800 3.4e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 9.43686e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 6.0e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005991//GO:0005985//GO:0005982 trehalose metabolic process//sucrose metabolic process//starch metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.32568 BF_2 30.93 0.43 3319 91081621 XP_966892.1 951 1.1e-99 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P31684 456 1.2e-43 4-coumarate--CoA ligase 1 OS=Solanum tuberosum GN=4CL1 PE=3 SV=1 PF15151//PF03144//PF00501 Response gene to complement 32 protein family//Elongation factor Tu domain 2//AMP-binding enzyme GO:0051726//GO:0008152 regulation of cell cycle//metabolic process GO:0003824//GO:0005525 catalytic activity//GTP binding -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.32569 BF_2 1687.26 15.40 4871 91094409 XP_967943.1 1484 2.6e-161 PREDICTED: acyl-CoA Delta(11) desaturase [Tribolium castaneum]>gi|270016351|gb|EFA12797.1| hypothetical protein TcasGA2_TC014819 [Tribolium castaneum]>gi|576636744|gb|AHH30814.1| fatty acid desaturase D7 [Tribolium castaneum] 817052910 XM_012403667.1 98 7.37176e-41 PREDICTED: Athalia rosae acyl-CoA Delta(11) desaturase (LOC105687776), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 902 3.3e-95 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 PF00487//PF00096 Fatty acid desaturase//Zinc finger, C2H2 type GO:0006633//GO:0006629//GO:0055114 fatty acid biosynthetic process//lipid metabolic process//oxidation-reduction process GO:0046872//GO:0016717 metal ion binding//oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016021 integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.3257 BF_2 2.00 0.40 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32570 BF_2 216.00 6.39 1701 91088695 XP_975014.1 1682 1.0e-184 PREDICTED: pre-mRNA-splicing factor RBM22 [Tribolium castaneum]>gi|270012288|gb|EFA08736.1| hypothetical protein TcasGA2_TC006411 [Tribolium castaneum] 768442180 XM_011564550.1 131 1.14918e-59 PREDICTED: Plutella xylostella pre-mRNA-splicing factor RBM22 (LOC105392866), mRNA K12872 RBM22, SLT11 pre-mRNA-splicing factor RBM22/SLT11 http://www.genome.jp/dbget-bin/www_bget?ko:K12872 Q8BHS3 1371 4.8e-150 Pre-mRNA-splicing factor RBM22 OS=Mus musculus GN=Rbm22 PE=1 SV=1 PF00076//PF08777//PF01363//PF00642 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif//FYVE zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0003723//GO:0008270//GO:0000166//GO:0003676 metal ion binding//RNA binding//zinc ion binding//nucleotide binding//nucleic acid binding -- -- KOG0153 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.32571 BF_2 2804.46 138.70 1133 546683906 ERL93654.1 312 4.9e-26 hypothetical protein D910_10942 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32572 BF_2 541.27 16.00 1702 642929992 XP_975639.2 782 2.3e-80 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QQM4 345 4.5e-31 Zinc finger protein 474 OS=Bos taurus GN=ZNF474 PE=2 SV=1 PF13465//PF00096//PF08782 Zinc-finger double domain//Zinc finger, C2H2 type//c-SKI Smad4 binding domain -- -- GO:0046872//GO:0046332 metal ion binding//SMAD binding -- -- -- -- Cluster-8309.32573 BF_2 12.00 1.06 761 345452847 AEN94575.1 803 3.8e-83 cyclophilin A [Scylla paramamosain]>gi|402536590|gb|AFQ62796.1| cyclophilin A [Scylla paramamosain] 345452846 HQ260921.1 757 0 Scylla paramamosain cyclophilin A mRNA, complete cds K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P25007 648 1.5e-66 Peptidyl-prolyl cis-trans isomerase OS=Drosophila melanogaster GN=Cyp1 PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.32576 BF_2 52.17 0.59 3958 642916252 XP_008190947.1 2331 1.3e-259 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 86 2.80185e-34 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 582 3.4e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF13499//PF14604//PF00018//PF00036//PF13405//PF12763 EF-hand domain pair//Variant SH3 domain//SH3 domain//EF hand//EF-hand domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.32577 BF_2 11.00 0.80 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32578 BF_2 48.84 0.31 6953 270005904 EFA02352.1 2947 0.0e+00 hypothetical protein TcasGA2_TC008022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 754 6.9e-78 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3321 Mitochondrial ribosomal protein S10 Cluster-8309.32579 BF_2 44.82 4.47 707 642919747 XP_008192048.1 232 5.7e-17 PREDICTED: transmembrane protein 131 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32581 BF_2 21.00 1.83 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32582 BF_2 62.35 2.32 1411 270005904 EFA02352.1 233 8.8e-17 hypothetical protein TcasGA2_TC008022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32584 BF_2 155.00 24.02 557 91085371 XP_971695.1 382 1.8e-34 PREDICTED: mitochondrial import inner membrane translocase subunit TIM16 [Tribolium castaneum]>gi|270009135|gb|EFA05583.1| hypothetical protein TcasGA2_TC015786 [Tribolium castaneum] -- -- -- -- -- K17805 PAM16, TIM16 mitochondrial import inner membrane translocase subunit TIM16 http://www.genome.jp/dbget-bin/www_bget?ko:K17805 Q6PBL0 276 1.5e-23 Mitochondrial import inner membrane translocase subunit tim16 OS=Danio rerio GN=pam16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3442 Uncharacterized conserved protein Cluster-8309.32585 BF_2 1456.83 33.43 2110 642933468 XP_973513.2 1908 7.8e-211 PREDICTED: homogentisate 1,2-dioxygenase [Tribolium castaneum] 687022014 LM523162.1 170 2.99054e-81 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000005 K00451 HGD, hmgA homogentisate 1,2-dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00451 O09173 1652 1.6e-182 Homogentisate 1,2-dioxygenase OS=Mus musculus GN=Hgd PE=1 SV=2 PF04209 homogentisate 1,2-dioxygenase GO:0006559//GO:0006570//GO:0055114//GO:0042207 L-phenylalanine catabolic process//tyrosine metabolic process//oxidation-reduction process//styrene catabolic process GO:0004411 homogentisate 1,2-dioxygenase activity -- -- KOG1417 Homogentisate 1,2-dioxygenase Cluster-8309.32586 BF_2 19.00 0.64 1521 795010007 XP_011864749.1 696 1.9e-70 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32588 BF_2 98.58 5.44 1045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32591 BF_2 44.55 0.52 3873 642916252 XP_008190947.1 2337 2.6e-260 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 94 9.78936e-39 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 580 5.8e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF00036//PF13405//PF13499//PF14604//PF00018//PF12763 EF hand//EF-hand domain//EF-hand domain pair//Variant SH3 domain//SH3 domain//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.32593 BF_2 220.07 1.97 4968 270004168 EFA00616.1 1791 6.8e-197 hypothetical protein TcasGA2_TC003491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15811 853 1.6e-89 Intersectin-1 OS=Homo sapiens GN=ITSN1 PE=1 SV=3 PF13181//PF00168//PF00621 Tetratricopeptide repeat//C2 domain//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.32594 BF_2 25.23 0.42 2803 91086121 XP_968297.1 555 8.0e-54 PREDICTED: adenine phosphoribosyltransferase [Tribolium castaneum]>gi|270010221|gb|EFA06669.1| hypothetical protein TcasGA2_TC009597 [Tribolium castaneum] -- -- -- -- -- K00759 APRT, apt adenine phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00759 P54363 472 1.4e-45 Adenine phosphoribosyltransferase OS=Drosophila pseudoobscura pseudoobscura GN=Aprt PE=3 SV=1 PF06689//PF03310//PF02465//PF04977//PF04799//PF00156 ClpX C4-type zinc finger//Caulimovirus DNA-binding protein//Flagellar hook-associated protein 2 N-terminus//Septum formation initiator//fzo-like conserved region//Phosphoribosyl transferase domain GO:1901564//GO:0055086//GO:0007049//GO:0009116//GO:0008053 organonitrogen compound metabolic process//nucleobase-containing small molecule metabolic process//cell cycle//nucleoside metabolic process//mitochondrial fusion GO:0008270//GO:0003924//GO:0046983//GO:0003677//GO:0016740 zinc ion binding//GTPase activity//protein dimerization activity//DNA binding//transferase activity GO:0009424//GO:0005741//GO:0016021 bacterial-type flagellum hook//mitochondrial outer membrane//integral component of membrane KOG1712 Adenine phosphoribosyl transferases Cluster-8309.32595 BF_2 332.70 1.91 7591 91076690 XP_971724.1 388 5.0e-34 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] -- -- -- -- -- K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 A3KP37 217 1.4e-15 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Danio rerio GN=ndufaf5 PE=2 SV=1 PF04690 YABBY protein GO:0007275 multicellular organismal development -- -- -- -- KOG2940 Predicted methyltransferase Cluster-8309.32596 BF_2 4.61 0.41 760 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32597 BF_2 15.00 1.35 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32598 BF_2 22.00 1.11 1114 546682135 ERL92116.1 910 2.2e-95 hypothetical protein D910_09436, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A6MFK7 297 1.1e-25 Venom prothrombin activator vestarin-D1 OS=Demansia vestigiata PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32601 BF_2 76.89 0.47 7089 642915712 XP_008190771.1 2157 3.5e-239 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 2.3e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF02454//PF00621 Sigma 1s protein//RhoGEF domain GO:0043087//GO:0035023//GO:0019048 regulation of GTPase activity//regulation of Rho protein signal transduction//modulation by virus of host morphology or physiology GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.32602 BF_2 90.97 2.75 1672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32604 BF_2 736.91 14.39 2429 91076548 XP_966358.1 499 2.2e-47 PREDICTED: anamorsin homolog [Tribolium castaneum]>gi|270002616|gb|EEZ99063.1| hypothetical protein TcasGA2_TC004939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17L24 426 2.6e-40 Anamorsin homolog OS=Aedes aegypti GN=AAEL001501 PE=3 SV=1 PF11095//PF07716//PF00010//PF05093 Gem-associated protein 7 (Gemin7)//Basic region leucine zipper//Helix-loop-helix DNA-binding domain//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0006355//GO:0016226 regulation of transcription, DNA-templated//iron-sulfur cluster assembly GO:0003700//GO:0043565//GO:0051536//GO:0046983 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//iron-sulfur cluster binding//protein dimerization activity GO:0032797//GO:0005737//GO:0005667 SMN complex//cytoplasm//transcription factor complex KOG4020 Protein DRE2, required for cell viability Cluster-8309.32606 BF_2 163.28 2.10 3545 642923805 XP_008193890.1 1839 1.3e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 6.9e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0003723//GO:0000166 nucleic acid binding//RNA binding//nucleotide binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.32607 BF_2 204.77 1.60 5631 91092490 XP_968084.1 602 5.7e-59 PREDICTED: protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [Tribolium castaneum]>gi|270012934|gb|EFA09382.1| hypothetical protein TcasGA2_TC001944 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMR3 558 3.0e-55 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 OS=Gallus gallus GN=PCMTD1 PE=2 SV=1 PF07664//PF07525//PF08704//PF01135//PF08123 Ferrous iron transport protein B C terminus//SOCS box//tRNA methyltransferase complex GCD14 subunit//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Histone methylation protein DOT1 GO:0030488//GO:0006464//GO:0006554//GO:0015684//GO:0008033//GO:0046500//GO:0035556//GO:0006479//GO:0009451 tRNA methylation//cellular protein modification process//lysine catabolic process//ferrous iron transport//tRNA processing//S-adenosylmethionine metabolic process//intracellular signal transduction//protein methylation//RNA modification GO:0016429//GO:0018024//GO:0015093//GO:0004719 tRNA (adenine-N1-)-methyltransferase activity//histone-lysine N-methyltransferase activity//ferrous iron transmembrane transporter activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0016021//GO:0031515 integral component of membrane//tRNA (m1A) methyltransferase complex KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.32608 BF_2 14.85 0.57 1377 332376847 AEE63563.1 1353 1.2e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01555 FAH, fahA fumarylacetoacetase http://www.genome.jp/dbget-bin/www_bget?ko:K01555 A5PKH3 1077 4.8e-116 Fumarylacetoacetase OS=Bos taurus GN=FAH PE=2 SV=1 PF01557//PF09298 Fumarylacetoacetate (FAA) hydrolase family//Fumarylacetoacetase N-terminal GO:0009072//GO:0008152//GO:0006570//GO:0042207 aromatic amino acid family metabolic process//metabolic process//tyrosine metabolic process//styrene catabolic process GO:0003824//GO:0004334 catalytic activity//fumarylacetoacetase activity -- -- KOG2843 Fumarylacetoacetase Cluster-8309.32609 BF_2 762.43 29.90 1354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3261 BF_2 8.00 0.76 729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32610 BF_2 18.00 0.36 2356 815810143 XP_012225962.1 189 1.9e-11 PREDICTED: zinc finger protein 467-like [Linepithema humile] -- -- -- -- -- -- -- -- -- Q7KQZ4 162 1.0e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF06467//PF01155//PF02150//PF13465//PF00096 MYM-type Zinc finger with FCS sequence motif//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006144//GO:0006351//GO:0006464 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//cellular protein modification process GO:0046872//GO:0008270//GO:0016151//GO:0003677//GO:0003899 metal ion binding//zinc ion binding//nickel cation binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG1721 FOG: Zn-finger Cluster-8309.32612 BF_2 16.30 0.37 2141 91091550 XP_971130.1 599 4.8e-59 PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|270000919|gb|EEZ97366.1| hypothetical protein TcasGA2_TC011188 [Tribolium castaneum]>gi|332373990|gb|AEE62136.1| unknown [Dendroctonus ponderosae]>gi|546685461|gb|ERL94965.1| hypothetical protein D910_12237 [Dendroctonus ponderosae] 657798762 XM_008328253.1 115 1.13899e-50 PREDICTED: Cynoglossus semilaevis ubiquitin-conjugating enzyme E2 A (LOC103391826), mRNA K10573 UBE2A, UBC2, RAD6A ubiquitin-conjugating enzyme E2 A http://www.genome.jp/dbget-bin/www_bget?ko:K10573 P25153 586 6.4e-59 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=UbcD6 PE=2 SV=2 PF05773 RWD domain -- -- GO:0005515//GO:0016881//GO:0005524 protein binding//acid-amino acid ligase activity//ATP binding -- -- KOG0419 Ubiquitin-protein ligase Cluster-8309.32613 BF_2 749.24 13.47 2614 642927700 XP_008196611.1 1675 1.0e-183 PREDICTED: LOW QUALITY PROTEIN: oxidative stress-induced growth inhibitor 2-like [Tribolium castaneum] 642927699 XM_008198389.1 99 1.09362e-41 PREDICTED: Tribolium castaneum oxidative stress-induced growth inhibitor 2-like (LOC655536), mRNA -- -- -- -- Q9UJX0 433 4.3e-41 Oxidative stress-induced growth inhibitor 1 OS=Homo sapiens GN=OSGIN1 PE=1 SV=3 PF07992//PF01494//PF00070 Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491//GO:0071949 oxidoreductase activity//FAD binding -- -- -- -- Cluster-8309.32614 BF_2 2543.39 57.36 2142 91085703 XP_972591.1 1384 4.6e-150 PREDICTED: uncharacterized protein LOC661334 isoform X2 [Tribolium castaneum]>gi|270010100|gb|EFA06548.1| hypothetical protein TcasGA2_TC009456 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11890 Domain of unknown function (DUF3410) -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.32616 BF_2 2679.63 44.13 2827 478256813 ENN76988.1 1692 1.2e-185 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] 195439161 XM_002067464.1 61 1.57442e-20 Drosophila willistoni GK16160 (Dwil\GK16160), mRNA K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 Q9NFT7 1051 1.0e-112 Hexokinase type 2 OS=Drosophila melanogaster GN=Hex-t2 PE=2 SV=4 PF00349//PF03727 Hexokinase//Hexokinase GO:0005975 carbohydrate metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG1369 Hexokinase Cluster-8309.32617 BF_2 54.71 0.44 5444 478256813 ENN76988.1 971 9.0e-102 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] 195439161 XM_002067464.1 46 6.65047e-12 Drosophila willistoni GK16160 (Dwil\GK16160), mRNA K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 Q9NFT7 577 1.8e-57 Hexokinase type 2 OS=Drosophila melanogaster GN=Hex-t2 PE=2 SV=4 PF03727//PF00349 Hexokinase//Hexokinase GO:0005975 carbohydrate metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG1369 Hexokinase Cluster-8309.32618 BF_2 59.67 0.66 4042 478256813 ENN76988.1 226 1.6e-15 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] -- -- -- -- -- K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 -- -- -- -- PF00349 Hexokinase GO:0005975 carbohydrate metabolic process GO:0005524//GO:0016773 ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.32619 BF_2 86.33 0.92 4211 478256813 ENN76988.1 271 1.0e-20 hypothetical protein YQE_06482, partial [Dendroctonus ponderosae]>gi|546673962|gb|ERL85470.1| hypothetical protein D910_02889 [Dendroctonus ponderosae] -- -- -- -- -- K00844 HK hexokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00844 -- -- -- -- PF00349 Hexokinase GO:0005975 carbohydrate metabolic process GO:0016773//GO:0005524 phosphotransferase activity, alcohol group as acceptor//ATP binding -- -- -- -- Cluster-8309.32620 BF_2 1344.15 17.41 3516 91082907 XP_972373.1 1236 1.1e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.6e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF07224//PF00787//PF00326//PF10503//PF12740 Chlorophyllase//PX domain//Prolyl oligopeptidase family//Esterase PHB depolymerase//Chlorophyllase enzyme GO:0006508//GO:0015996//GO:0015947//GO:0046294//GO:0015994 proteolysis//chlorophyll catabolic process//methane metabolic process//formaldehyde catabolic process//chlorophyll metabolic process GO:0008236//GO:0018738//GO:0035091//GO:0047746 serine-type peptidase activity//S-formylglutathione hydrolase activity//phosphatidylinositol binding//chlorophyllase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.32621 BF_2 849.61 11.00 3518 91082907 XP_972373.1 1236 1.1e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.6e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF12740//PF10503//PF00326//PF00787//PF07224 Chlorophyllase enzyme//Esterase PHB depolymerase//Prolyl oligopeptidase family//PX domain//Chlorophyllase GO:0015947//GO:0015996//GO:0015994//GO:0046294//GO:0006508 methane metabolic process//chlorophyll catabolic process//chlorophyll metabolic process//formaldehyde catabolic process//proteolysis GO:0035091//GO:0047746//GO:0018738//GO:0008236 phosphatidylinositol binding//chlorophyllase activity//S-formylglutathione hydrolase activity//serine-type peptidase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.32622 BF_2 1307.49 47.90 1429 91090428 XP_971598.1 650 3.9e-65 PREDICTED: THO complex subunit 4 [Tribolium castaneum]>gi|270013379|gb|EFA09827.1| hypothetical protein TcasGA2_TC011974 [Tribolium castaneum] -- -- -- -- -- K12881 THOC4, ALY THO complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12881 Q58EA2 383 1.5e-35 THO complex subunit 4-A OS=Xenopus laevis GN=alyref-a PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.32623 BF_2 1865.96 32.38 2698 91080851 XP_971681.1 2083 5.1e-231 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 1203 2.3e-130 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF13304//PF01637//PF01061//PF03193//PF00005//PF00004 AAA domain, putative AbiEii toxin, Type IV TA system//Archaeal ATPase//ABC-2 type transporter//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA) -- -- GO:0016887//GO:0005525//GO:0005524//GO:0000166//GO:0017111//GO:0003924 ATPase activity//GTP binding//ATP binding//nucleotide binding//nucleoside-triphosphatase activity//GTPase activity GO:0016020 membrane -- -- Cluster-8309.32625 BF_2 244.00 5.26 2226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32626 BF_2 6.09 0.84 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32627 BF_2 3.91 0.73 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32629 BF_2 15.33 0.38 1957 270004866 EFA01314.1 659 4.9e-66 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 484 3.9e-47 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0020037//GO:0009055 heme binding//electron carrier activity -- -- -- -- Cluster-8309.32632 BF_2 54.22 1.03 2488 478256780 ENN76958.1 397 1.5e-35 hypothetical protein YQE_06526, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00727 Interleukin 4 GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0008083//GO:0005136 growth factor activity//interleukin-4 receptor binding GO:0005576//GO:0016516 extracellular region//interleukin-4 receptor complex -- -- Cluster-8309.32633 BF_2 1316.24 14.11 4189 91084825 XP_973466.1 1748 5.5e-192 PREDICTED: GAS2-like protein 2 [Tribolium castaneum]>gi|642925938|ref|XP_008194703.1| PREDICTED: GAS2-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZP9 712 3.1e-73 GAS2-like protein 1 OS=Mus musculus GN=Gas2l1 PE=2 SV=1 PF02187//PF00307 Growth-Arrest-Specific Protein 2 Domain//Calponin homology (CH) domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.32634 BF_2 79.18 2.52 1601 189235746 XP_967247.2 510 7.6e-49 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 307 1.1e-26 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137//PF08117 Adenosine-deaminase (editase) domain//Ptu family GO:0006810//GO:0006144//GO:0009405//GO:0006396//GO:0006807 transport//purine nucleobase metabolic process//pathogenesis//RNA processing//nitrogen compound metabolic process GO:0004000//GO:0003723//GO:0019855 adenosine deaminase activity//RNA binding//calcium channel inhibitor activity GO:0005576 extracellular region KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.32635 BF_2 367.17 3.38 4826 270006379 EFA02827.1 1550 5.8e-169 plenty of SH3s [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.0e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF17123//PF14634//PF00097//PF02891//PF09360//PF14604//PF00018//PF13639//PF16685 RING-like zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//Iron-binding zinc finger CDGSH type//Variant SH3 domain//SH3 domain//Ring finger domain//zinc RING finger of MSL2 -- -- GO:0046872//GO:0005515//GO:0061630//GO:0051537//GO:0008270 metal ion binding//protein binding//ubiquitin protein ligase activity//2 iron, 2 sulfur cluster binding//zinc ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.32636 BF_2 281.00 11.21 1336 270007614 EFA04062.1 1060 1.1e-112 hypothetical protein TcasGA2_TC014295 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5HZI9 647 3.4e-66 Solute carrier family 25 member 51 OS=Mus musculus GN=Slc25a51 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1519 Predicted mitochondrial carrier protein Cluster-8309.32638 BF_2 158.94 0.76 9026 642923445 XP_008193747.1 789 1.9e-80 PREDICTED: COP9 signalosome complex subunit 8 [Tribolium castaneum]>gi|270008317|gb|EFA04765.1| hypothetical protein TcasGA2_TC030655 [Tribolium castaneum] -- -- -- -- -- K12181 COPS8, CSN8 COP9 signalosome complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12181 Q6GQA6 469 1.0e-44 COP9 signalosome complex subunit 8 OS=Xenopus laevis GN=csn8 PE=2 SV=2 PF04069//PF01399 Substrate binding domain of ABC-type glycine betaine transport system//PCI domain GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity -- -- -- -- Cluster-8309.32639 BF_2 2119.47 34.54 2854 642915300 XP_008190561.1 2869 0.0e+00 PREDICTED: JNK-interacting protein 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29EP6 1279 3.7e-139 JNK-interacting protein 3 OS=Drosophila pseudoobscura pseudoobscura GN=syd PE=3 SV=2 PF10186//PF04508//PF01763 Vacuolar sorting 38 and autophagy-related subunit 14//Viral A-type inclusion protein repeat//Herpesvirus UL6 like GO:0016032//GO:0006323//GO:0010508 viral process//DNA packaging//positive regulation of autophagy -- -- -- -- KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.3264 BF_2 6.00 0.46 836 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32640 BF_2 90.25 4.47 1131 478251739 ENN72191.1 347 4.3e-30 hypothetical protein YQE_11151, partial [Dendroctonus ponderosae]>gi|546670640|gb|ERL83324.1| hypothetical protein D910_00219 [Dendroctonus ponderosae]>gi|546672556|gb|ERL84373.1| hypothetical protein D910_01801 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32641 BF_2 12.00 1.15 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32644 BF_2 81.00 3.11 1378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32649 BF_2 25.37 0.41 2865 642919713 XP_008192033.1 1789 6.7e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.6e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.3265 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32650 BF_2 234.30 1.50 6803 642914427 XP_008201492.1 5265 0.0e+00 PREDICTED: rootletin [Tribolium castaneum] 462381540 APGK01021978.1 59 4.93573e-19 Dendroctonus ponderosae Seq01021988, whole genome shotgun sequence K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 1416 1.2e-154 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF16331//PF10473//PF07851//PF16326//PF04111//PF07926 TolA binding protein trimerisation//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TMPIT-like protein//ABC transporter C-terminal domain//Autophagy protein Apg6//TPR/MLP1/MLP2-like protein GO:0070206//GO:0006914//GO:0006606 protein trimerization//autophagy//protein import into nucleus GO:0003677//GO:0045502//GO:0008134//GO:0042803 DNA binding//dynein binding//transcription factor binding//protein homodimerization activity GO:0030286//GO:0016021//GO:0005667 dynein complex//integral component of membrane//transcription factor complex -- -- Cluster-8309.32651 BF_2 1050.53 19.85 2501 546682338 ERL92286.1 1156 1.5e-123 hypothetical protein D910_09603 [Dendroctonus ponderosae] -- -- -- -- -- K15728 LPIN phosphatidate phosphatase LPIN http://www.genome.jp/dbget-bin/www_bget?ko:K15728 Q99PI4 385 1.5e-35 Phosphatidate phosphatase LPIN3 OS=Mus musculus GN=Lpin3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2116 Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism Cluster-8309.32655 BF_2 48.41 0.75 2985 270006239 EFA02687.1 3258 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1457 9.0e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02020//PF02854//PF02180 eIF4-gamma/eIF5/eIF2-epsilon//MIF4G domain//Bcl-2 homology region 4 GO:0042981 regulation of apoptotic process GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.32656 BF_2 30.00 3.42 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32657 BF_2 470.80 7.79 2816 270006239 EFA02687.1 3258 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1457 8.5e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02854//PF02020 MIF4G domain//eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.32658 BF_2 92.37 1.40 3048 270006239 EFA02687.1 3303 0.0e+00 hypothetical protein TcasGA2_TC008408 [Tribolium castaneum] -- -- -- -- -- K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 P79398 1459 5.4e-160 Eukaryotic translation initiation factor 4 gamma 2 OS=Oryctolagus cuniculus GN=EIF4G2 PE=2 SV=1 PF02854//PF02180//PF02020//PF00763 MIF4G domain//Bcl-2 homology region 4//eIF4-gamma/eIF5/eIF2-epsilon//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0046487//GO:0009396//GO:0055114//GO:0042981 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process//regulation of apoptotic process GO:0004488//GO:0005515//GO:0003723//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//protein binding//RNA binding//catalytic activity -- -- KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.32659 BF_2 28.00 13.26 373 734614522 XP_010734822.1 217 1.7e-15 PREDICTED: polyubiquitin-B isoform X6 [Larimichthys crocea] 462370374 APGK01025878.1 75 3.16732e-29 Dendroctonus ponderosae Seq01025888, whole genome shotgun sequence K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 212 2.6e-16 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.32660 BF_2 26.89 0.31 3933 642911078 XP_008200566.1 2414 3.1e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 3.5e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF00641//PF07808//PF01585//PF13442//PF11648 Zn-finger in Ran binding protein and others//RED-like protein N-terminal region//G-patch domain//Cytochrome C oxidase, cbb3-type, subunit III//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0008270//GO:0000166//GO:0009055//GO:0003676//GO:0020037//GO:0016817 zinc ion binding//nucleotide binding//electron carrier activity//nucleic acid binding//heme binding//hydrolase activity, acting on acid anhydrides GO:0005634//GO:0005622 nucleus//intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32663 BF_2 2.00 4.11 284 642939656 XP_008194276.1 230 3.9e-17 PREDICTED: serine protease snake-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 159 2.8e-10 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32664 BF_2 8.00 0.64 808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32666 BF_2 683.10 4.47 6680 642916405 XP_008191009.1 2357 2.1e-262 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.7e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF00018//PF14604//PF09360//PF03114 IRSp53/MIM homology domain//SH3 domain//Variant SH3 domain//Iron-binding zinc finger CDGSH type//BAR domain GO:0007009 plasma membrane organization GO:0005515//GO:0051537 protein binding//2 iron, 2 sulfur cluster binding GO:0005737//GO:0043231 cytoplasm//intracellular membrane-bounded organelle -- -- Cluster-8309.32667 BF_2 61.35 2.72 1232 478256542 ENN76726.1 203 2.3e-13 hypothetical protein YQE_06791, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q52KB5 152 7.8e-09 Zinc finger and BTB domain-containing protein 24 OS=Danio rerio GN=zbtb24 PE=2 SV=1 PF16622//PF00096 zinc-finger C2H2-type//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.3267 BF_2 18.00 3.06 533 241998774 XP_002434030.1 750 3.7e-77 ribosomal protein L12, putative [Ixodes scapularis]>gi|67083811|gb|AAY66840.1| ribosomal protein L12 [Ixodes scapularis]>gi|215495789|gb|EEC05430.1| ribosomal protein L12, putative [Ixodes scapularis] 548348113 XM_005726377.1 104 3.51695e-45 PREDICTED: Pundamilia nyererei 60S ribosomal protein L12-like (LOC102216198), mRNA K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61284 683 9.0e-71 60S ribosomal protein L12 OS=Bos taurus GN=RPL12 PE=2 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-8309.32670 BF_2 233.00 36.11 557 332373602 AEE61942.1 475 3.0e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm -- -- Cluster-8309.32672 BF_2 21.00 0.61 1723 642918391 XP_008200125.1 965 1.4e-101 PREDICTED: zinc finger protein 271-like [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q61116 507 7.5e-50 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF01155//PF13465//PF00096//PF04810//PF01584//PF13912 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type//Sec23/Sec24 zinc finger//CheW-like domain//C2H2-type zinc finger GO:0006888//GO:0006886//GO:0006935//GO:0006464//GO:0007165 ER to Golgi vesicle-mediated transport//intracellular protein transport//chemotaxis//cellular protein modification process//signal transduction GO:0016151//GO:0046872//GO:0004871//GO:0008270 nickel cation binding//metal ion binding//signal transducer activity//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.32673 BF_2 64.00 1.48 2098 471396316 XP_004381787.1 595 1.4e-58 PREDICTED: zinc finger protein 615 isoform X1 [Trichechus manatus latirostris] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 554 3.2e-55 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF01197//PF13465//PF00096//PF16622//PF02350//PF13912 Ribosomal protein L31//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//UDP-N-acetylglucosamine 2-epimerase//C2H2-type zinc finger GO:0006047//GO:0042254//GO:0006412 UDP-N-acetylglucosamine metabolic process//ribosome biogenesis//translation GO:0003735//GO:0046872 structural constituent of ribosome//metal ion binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.32675 BF_2 23.00 3.40 570 478256535 ENN76719.1 425 1.9e-39 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6QLU5 201 7.5e-15 Zinc finger protein 184 OS=Bos taurus GN=ZNF184 PE=2 SV=1 PF13465//PF00096//PF07535//PF01363//PF04810 Zinc-finger double domain//Zinc finger, C2H2 type//DBF zinc finger//FYVE zinc finger//Sec23/Sec24 zinc finger GO:0006886//GO:0006888 intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.32677 BF_2 505.29 2.90 7570 478256535 ENN76719.1 1038 2.1e-109 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 683942502 XM_009101103.1 36 3.35441e-06 PREDICTED: Serinus canaria zinc finger protein 329-like (LOC103825865), partial mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 629 2.3e-63 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF12142//PF07975//PF04810//PF13912//PF01428//PF16622//PF05191//PF00096//PF00130//PF01155//PF06397//PF04889//PF07776 Zinc-finger double domain//Polyphenol oxidase middle domain//TFIIH C1-like domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//Cwf15/Cwc15 cell cycle control protein//Zinc-finger associated domain (zf-AD) GO:0006464//GO:0006570//GO:0006281//GO:0006886//GO:0046034//GO:0006118//GO:0000398//GO:0035556//GO:0055114//GO:0006888//GO:0006144 cellular protein modification process//tyrosine metabolic process//DNA repair//intracellular protein transport//ATP metabolic process//obsolete electron transport//mRNA splicing, via spliceosome//intracellular signal transduction//oxidation-reduction process//ER to Golgi vesicle-mediated transport//purine nucleobase metabolic process GO:0004097//GO:0008270//GO:0005506//GO:0004017//GO:0016151//GO:0046872 catechol oxidase activity//zinc ion binding//iron ion binding//adenylate kinase activity//nickel cation binding//metal ion binding GO:0030127//GO:0005634//GO:0005681 COPII vesicle coat//nucleus//spliceosomal complex -- -- Cluster-8309.32681 BF_2 41.90 0.95 2139 524894604 XP_005103798.1 196 2.6e-12 PREDICTED: zinc finger protein 431-like [Aplysia californica] -- -- -- -- -- -- -- -- -- Q08876 138 5.7e-07 Protein suppressor of hairy wing OS=Drosophila virilis GN=su(Hw) PE=2 SV=1 PF13912//PF02290//PF00096//PF13465 C2H2-type zinc finger//Signal recognition particle 14kD protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0046872//GO:0008312//GO:0030942 metal ion binding//7S RNA binding//endoplasmic reticulum signal peptide binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting -- -- Cluster-8309.32682 BF_2 253.56 3.47 3344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32683 BF_2 936.24 3.98 10127 478256535 ENN76719.1 1015 1.3e-106 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86WZ6 552 2.7e-54 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF07776//PF01256//PF00412//PF13912//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Carbohydrate kinase//LIM domain//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0052855//GO:0008270//GO:0046872 ADP-dependent NAD(P)H-hydrate dehydratase activity//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.32686 BF_2 4436.41 221.77 1124 189236533 XP_975493.2 1064 3.1e-113 PREDICTED: triosephosphate isomerase [Tribolium castaneum]>gi|270005300|gb|EFA01748.1| hypothetical protein TcasGA2_TC007346 [Tribolium castaneum] 440200132 JQ784063.1 57 1.02955e-18 Eriocraniella aurosparsella voucher Erau triosephosphate isomerase mRNA, partial cds K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P30741 972 5.9e-104 Triosephosphate isomerase OS=Culex tarsalis GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006094//GO:0015976//GO:0046486//GO:0006000//GO:0006013//GO:0008152//GO:0006096//GO:0006020 gluconeogenesis//carbon utilization//glycerolipid metabolic process//fructose metabolic process//mannose metabolic process//metabolic process//glycolytic process//inositol metabolic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.32687 BF_2 46.14 0.32 6313 642917185 XP_966369.3 1730 1.0e-189 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 944 5.8e-100 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.32690 BF_2 462.14 20.14 1247 189238165 XP_973195.2 697 1.2e-70 PREDICTED: serine protease gd-like [Tribolium castaneum]>gi|642925379|ref|XP_008194524.1| PREDICTED: serine protease gd-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 493 2.3e-48 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32692 BF_2 40.99 0.40 4626 642932474 XP_008197131.1 1119 5.3e-119 PREDICTED: uncharacterized protein LOC662025 isoform X1 [Tribolium castaneum] 642932473 XM_008198909.1 192 3.89651e-93 PREDICTED: Tribolium castaneum uncharacterized LOC662025 (LOC662025), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32693 BF_2 29.00 0.42 3157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32694 BF_2 211.72 30.03 582 741829858 AJA91073.1 625 1.3e-62 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 500 1.6e-49 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.32695 BF_2 8.22 0.57 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32696 BF_2 219.66 2.12 4614 332373726 AEE62004.1 428 7.0e-39 unknown [Dendroctonus ponderosae]>gi|478250918|gb|ENN71403.1| hypothetical protein YQE_11907, partial [Dendroctonus ponderosae]>gi|546684873|gb|ERL94455.1| hypothetical protein D910_11732 [Dendroctonus ponderosae] -- -- -- -- -- K03873 TCEB2 transcription elongation factor B, polypeptide 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03873 P62870 254 4.3e-20 Transcription elongation factor B polypeptide 2 OS=Rattus norvegicus GN=Tceb2 PE=1 SV=1 PF00046//PF05920//PF00240//PF14560 Homeobox domain//Homeobox KN domain//Ubiquitin family//Ubiquitin-like domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0483 Transcription factor HEX, contains HOX and HALZ domains Cluster-8309.32697 BF_2 101.02 2.18 2223 642911484 XP_008199443.1 1321 9.6e-143 PREDICTED: uncharacterized protein LOC662426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15599 151 1.8e-08 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens GN=SLC9A3R2 PE=1 SV=2 PF00595//PF13180//PF03145//PF14634//PF13639 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Seven in absentia protein family//zinc-RING finger domain//Ring finger domain GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.32698 BF_2 58.90 1.50 1934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3270 BF_2 62.18 4.81 828 91092914 XP_971430.1 888 5.8e-93 PREDICTED: DNA-directed RNA polymerase III subunit RPC8 [Tribolium castaneum]>gi|642916922|ref|XP_008199556.1| PREDICTED: DNA-directed RNA polymerase III subunit RPC8 [Tribolium castaneum]>gi|270003098|gb|EEZ99545.1| hypothetical protein TcasGA2_TC000127 [Tribolium castaneum] -- -- -- -- -- K03022 RPC8, POLR3H DNA-directed RNA polymerase III subunit RPC8 http://www.genome.jp/dbget-bin/www_bget?ko:K03022 Q9D2C6 642 7.9e-66 DNA-directed RNA polymerase III subunit RPC8 OS=Mus musculus GN=Polr3h PE=2 SV=2 PF03876 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3297 DNA-directed RNA polymerase subunit E' Cluster-8309.32702 BF_2 66.84 0.75 4020 642912996 XP_008201344.1 1501 2.3e-163 PREDICTED: synaptic vesicle glycoprotein 2C-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 445 2.7e-42 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.32703 BF_2 578.35 3.79 6674 91090320 XP_972446.1 3083 0.0e+00 PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|642934930|ref|XP_008197867.1| PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|270013809|gb|EFA10257.1| hypothetical protein TcasGA2_TC012457 [Tribolium castaneum] 642934932 XM_967353.2 859 0 PREDICTED: Tribolium castaneum rho-related BTB domain-containing protein 2 (LOC661174), transcript variant X3, mRNA K07868 RHOBTB1_2 Rho-related BTB domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07868 Q9DAK3 1118 4.1e-120 Rho-related BTB domain-containing protein 1 OS=Mus musculus GN=Rhobtb1 PE=1 SV=2 PF00071//PF08477//PF00651 Ras family//Ras of Complex, Roc, domain of DAPkinase//BTB/POZ domain GO:0007264 small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding GO:0005622 intracellular -- -- Cluster-8309.32708 BF_2 223.00 14.60 926 642925814 XP_970128.3 386 1.0e-34 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 227 1.2e-17 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01370//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.32709 BF_2 638.30 7.21 3992 91081955 XP_967420.1 3702 0.0e+00 PREDICTED: cullin-3 [Tribolium castaneum]>gi|270007361|gb|EFA03809.1| hypothetical protein TcasGA2_TC013922 [Tribolium castaneum] 755982854 XM_011311736.1 344 1.07099e-177 PREDICTED: Fopius arisanus cullin-3 (LOC105270650), mRNA K03869 CUL3 cullin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03869 B5DF89 3025 0.0e+00 Cullin-3 OS=Rattus norvegicus GN=Cul3 PE=1 SV=2 PF02023//PF00888//PF12422 SCAN domain//Cullin family//Condensin II non structural maintenance of chromosomes subunit GO:0006511//GO:0006355 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0031625 transcription factor activity, sequence-specific DNA binding//ubiquitin protein ligase binding GO:0005667//GO:0005634//GO:0031461 transcription factor complex//nucleus//cullin-RING ubiquitin ligase complex KOG2166 Cullins Cluster-8309.32712 BF_2 14.85 0.63 1271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32714 BF_2 1.00 14.52 224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32715 BF_2 37.33 1.49 1336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32716 BF_2 14.00 27.42 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32717 BF_2 803.89 18.55 2100 91076586 XP_968109.1 1304 8.5e-141 PREDICTED: ras suppressor protein 1 [Tribolium castaneum] 642912649 XM_963016.3 201 1.74119e-98 PREDICTED: Tribolium castaneum ras suppressor protein 1 (LOC656490), mRNA -- -- -- -- Q5E9C0 888 6.0e-94 Ras suppressor protein 1 OS=Bos taurus GN=RSU1 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.32720 BF_2 8.00 4.71 354 642937488 XP_008198860.1 261 1.2e-20 PREDICTED: protein tramtrack, beta isoform-like isoform X21 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32721 BF_2 1101.27 39.18 1463 91081331 XP_970657.1 1014 2.5e-107 PREDICTED: Krueppel homolog 2 [Tribolium castaneum]>gi|270005195|gb|EFA01643.1| hypothetical protein TcasGA2_TC007213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V447 663 5.2e-68 Krueppel homolog 2 OS=Drosophila melanogaster GN=Kr-h2 PE=1 SV=1 PF03661 Uncharacterised protein family (UPF0121) -- -- -- -- GO:0016021 integral component of membrane KOG4002 Uncharacterized integral membrane protein Cluster-8309.32722 BF_2 883.12 60.78 895 91083773 XP_972220.1 361 8.0e-32 PREDICTED: uncharacterized protein LOC660933 [Tribolium castaneum]>gi|270006783|gb|EFA03231.1| hypothetical protein TcasGA2_TC013160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01084//PF01395//PF00335 Ribosomal protein S18//PBP/GOBP family//Tetraspanin family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005549 structural constituent of ribosome//odorant binding GO:0005840//GO:0016021//GO:0005622 ribosome//integral component of membrane//intracellular -- -- Cluster-8309.32724 BF_2 756.00 11.04 3152 546678469 ERL89077.1 1054 1.2e-111 hypothetical protein D910_06454 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF06881 F-box domain//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.32725 BF_2 662.90 5.15 5673 642927080 XP_008195128.1 5567 0.0e+00 PREDICTED: intron-binding protein aquarius [Tribolium castaneum] 602701425 XM_007462507.1 236 1.66129e-117 PREDICTED: Lipotes vexillifer aquarius intron-binding spliceosomal factor (AQR), mRNA K12874 AQR intron-binding protein aquarius http://www.genome.jp/dbget-bin/www_bget?ko:K12874 O60306 4522 0.0e+00 Intron-binding protein aquarius OS=Homo sapiens GN=AQR PE=1 SV=4 PF00004//PF00154//PF07728//PF03796//PF01057//PF00270//PF02337//PF00580//PF02562//PF04851//PF06414 ATPase family associated with various cellular activities (AAA)//recA bacterial DNA recombination protein//AAA domain (dynein-related subfamily)//DnaB-like helicase C terminal domain//Parvovirus non-structural protein NS1//DEAD/DEAH box helicase//Retroviral GAG p10 protein//UvrD/REP helicase N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit//Zeta toxin GO:0009432//GO:0006260//GO:0006281//GO:0019079 SOS response//DNA replication//DNA repair//viral genome replication GO:0016887//GO:0016301//GO:0003676//GO:0005198//GO:0003678//GO:0005524//GO:0016787//GO:0003677//GO:0003697 ATPase activity//kinase activity//nucleic acid binding//structural molecule activity//DNA helicase activity//ATP binding//hydrolase activity//DNA binding//single-stranded DNA binding GO:0005657//GO:0019028 replication fork//viral capsid KOG1806 DEAD box containing helicases Cluster-8309.32726 BF_2 74.10 1.24 2778 642927080 XP_008195128.1 3495 0.0e+00 PREDICTED: intron-binding protein aquarius [Tribolium castaneum] 564234202 XM_006273981.1 149 1.86423e-69 PREDICTED: Alligator mississippiensis aquarius intron-binding spliceosomal factor (AQR), mRNA K12874 AQR intron-binding protein aquarius http://www.genome.jp/dbget-bin/www_bget?ko:K12874 O60306 2535 8.3e-285 Intron-binding protein aquarius OS=Homo sapiens GN=AQR PE=1 SV=4 PF00270//PF00910//PF02337//PF00580//PF02456//PF02562//PF06414//PF04851//PF00004//PF07728//PF01057//PF05496//PF03796//PF06068 DEAD/DEAH box helicase//RNA helicase//Retroviral GAG p10 protein//UvrD/REP helicase N-terminal domain//Adenovirus IVa2 protein//PhoH-like protein//Zeta toxin//Type III restriction enzyme, res subunit//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//DnaB-like helicase C terminal domain//TIP49 C-terminus GO:0006310//GO:0006260//GO:0019079//GO:0019083//GO:0006281 DNA recombination//DNA replication//viral genome replication//viral transcription//DNA repair GO:0003676//GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0003677//GO:0016301//GO:0016887//GO:0005524//GO:0016787//GO:0005198 nucleic acid binding//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//DNA binding//kinase activity//ATPase activity//ATP binding//hydrolase activity//structural molecule activity GO:0005657//GO:0009379//GO:0019028 replication fork//Holliday junction helicase complex//viral capsid KOG1806 DEAD box containing helicases Cluster-8309.32727 BF_2 108.00 456.72 258 332376611 AEE63445.1 154 2.3e-08 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32728 BF_2 237.69 4.12 2701 642928332 XP_008195538.1 754 6.5e-77 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 P81139 302 6.9e-26 Pancreatic lipase-related protein 2 OS=Cavia porcellus GN=PNLIPRP2 PE=1 SV=1 PF01764//PF12740//PF07859//PF07819//PF00326//PF06821//PF00975 Lipase (class 3)//Chlorophyllase enzyme//alpha/beta hydrolase fold//PGAP1-like protein//Prolyl oligopeptidase family//Serine hydrolase//Thioesterase domain GO:0008152//GO:0006505//GO:0015996//GO:0015994//GO:0006886//GO:0006629//GO:0006508//GO:0009058 metabolic process//GPI anchor metabolic process//chlorophyll catabolic process//chlorophyll metabolic process//intracellular protein transport//lipid metabolic process//proteolysis//biosynthetic process GO:0016788//GO:0016787//GO:0047746//GO:0008236 hydrolase activity, acting on ester bonds//hydrolase activity//chlorophyllase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.32729 BF_2 67.61 1.74 1909 332373514 AEE61898.1 538 5.1e-52 unknown [Dendroctonus ponderosae] 642934342 XM_008200388.1 93 1.72015e-38 PREDICTED: Tribolium castaneum uncharacterized LOC103314398 (LOC103314398), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32731 BF_2 16.00 0.96 988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32732 BF_2 1164.96 13.21 3977 146411532 ABQ39970.1 2297 1.1e-255 heat shock protein 70 [Anatolica polita borealis] 645000994 XM_001599723.3 308 1.09755e-157 PREDICTED: Nasonia vitripennis heat shock protein 68-like (LOC100114907), mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P41825 2118 2.7e-236 Heat shock protein 70 A1 OS=Anopheles albimanus GN=HSP70A1 PE=3 SV=1 PF01968//PF00560//PF02782//PF13855//PF06723 Hydantoinase/oxoprolinase//Leucine Rich Repeat//FGGY family of carbohydrate kinases, C-terminal domain//Leucine rich repeat//MreB/Mbl protein GO:0000902//GO:0005975 cell morphogenesis//carbohydrate metabolic process GO:0016787//GO:0016773//GO:0005515 hydrolase activity//phosphotransferase activity, alcohol group as acceptor//protein binding -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.32733 BF_2 1033.78 7.58 5989 642936804 XP_008199623.1 5539 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 6.7e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF07926//PF10473//PF06160//PF08702//PF00910//PF01695//PF07728//PF04111//PF16326//PF00004//PF13851//PF16716//PF01832 TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Fibrinogen alpha/beta chain family//RNA helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Autophagy protein Apg6//ABC transporter C-terminal domain//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//Bone marrow stromal antigen 2//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase GO:0030168//GO:0018874//GO:0048870//GO:0000921//GO:0006560//GO:0051607//GO:0006568//GO:0006558//GO:0006606//GO:0042207//GO:0006525//GO:0007165//GO:0051258//GO:0006914 platelet activation//benzoate metabolic process//cell motility//septin ring assembly//proline metabolic process//defense response to virus//tryptophan metabolic process//L-phenylalanine metabolic process//protein import into nucleus//styrene catabolic process//arginine metabolic process//signal transduction//protein polymerization//autophagy GO:0030674//GO:0042803//GO:0003724//GO:0003677//GO:0003723//GO:0004040//GO:0005102//GO:0016887//GO:0005524//GO:0008134//GO:0045502 protein binding, bridging//protein homodimerization activity//RNA helicase activity//DNA binding//RNA binding//amidase activity//receptor binding//ATPase activity//ATP binding//transcription factor binding//dynein binding GO:0030286//GO:0005667//GO:0005577//GO:0031514//GO:0016021//GO:0005940 dynein complex//transcription factor complex//fibrinogen complex//motile cilium//integral component of membrane//septin ring -- -- Cluster-8309.32734 BF_2 1012.31 13.20 3495 642920452 XP_008192356.1 1383 9.7e-150 PREDICTED: protein croquemort isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 956 1.3e-101 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.32735 BF_2 743.85 14.22 2476 642920452 XP_008192356.1 1383 6.9e-150 PREDICTED: protein croquemort isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 956 9.3e-102 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.32736 BF_2 72.63 2.94 1322 91085965 XP_971530.1 1204 2.1e-129 PREDICTED: protein ERGIC-53 [Tribolium castaneum]>gi|270010174|gb|EFA06622.1| hypothetical protein TcasGA2_TC009540 [Tribolium castaneum] -- -- -- -- -- K10080 LMAN1, ERGIC53 lectin, mannose-binding 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10080 Q62902 838 2.4e-88 Protein ERGIC-53 OS=Rattus norvegicus GN=Lman1 PE=1 SV=1 PF03388//PF00139 Legume-like lectin family//Legume lectin domain -- -- GO:0030246 carbohydrate binding GO:0016020 membrane KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.32737 BF_2 801.91 47.59 992 817194376 XP_012272686.1 1072 3.2e-114 PREDICTED: 40S ribosomal protein S4 [Orussus abietinus] 264667394 GU120433.1 298 9.66998e-153 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 1090 1.1e-117 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.32738 BF_2 357.45 2.88 5478 688589261 XP_009290233.1 275 4.6e-21 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 150 1.02871e-69 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q99676 246 4.4e-19 Zinc finger protein 184 OS=Homo sapiens GN=ZNF184 PE=1 SV=4 PF13465//PF00076//PF16367//PF13912//PF02892//PF00096//PF05495//PF03868//PF02207//PF05478 Zinc-finger double domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//CHY zinc finger//Ribosomal protein L6, N-terminal domain//Putative zinc finger in N-recognin (UBR box)//Prominin GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735//GO:0003676//GO:0046872//GO:0003677 zinc ion binding//structural constituent of ribosome//nucleic acid binding//metal ion binding//DNA binding GO:0005840//GO:0005622//GO:0016021 ribosome//intracellular//integral component of membrane -- -- Cluster-8309.32740 BF_2 47.22 1.95 1298 478252683 ENN73079.1 193 3.5e-12 hypothetical protein YQE_10283, partial [Dendroctonus ponderosae]>gi|546682842|gb|ERL92731.1| hypothetical protein D910_10041 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32741 BF_2 1435.41 105.38 857 264667363 ACY71267.1 534 6.7e-52 ribosomal protein S24 [Chrysomela tremula] 642917806 XM_962484.3 218 2.46159e-108 PREDICTED: Tribolium castaneum 40S ribosomal protein S24 (LOC655928), mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 511 1.3e-50 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282//PF00276 Ribosomal protein S24e//Ribosomal protein L23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-8309.32742 BF_2 1805.76 9.83 7971 642926973 XP_008195085.1 3274 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 8.7e-77 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF00130//PF05529//PF00621//PF03650//PF07649//PF05791//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//B-cell receptor-associated protein 31-like//RhoGEF domain//Uncharacterised protein family (UPF0041)//C1-like domain//Bacillus haemolytic enterotoxin (HBL)//PHD-finger GO:0006850//GO:0006886//GO:0009405//GO:0035023//GO:0055114//GO:0035556//GO:0043087 mitochondrial pyruvate transport//intracellular protein transport//pathogenesis//regulation of Rho protein signal transduction//oxidation-reduction process//intracellular signal transduction//regulation of GTPase activity GO:0005515//GO:0005089//GO:0047134 protein binding//Rho guanyl-nucleotide exchange factor activity//protein-disulfide reductase activity GO:0005783//GO:0016021//GO:0005743//GO:0016020 endoplasmic reticulum//integral component of membrane//mitochondrial inner membrane//membrane -- -- Cluster-8309.32743 BF_2 139.42 3.63 1896 642921071 XP_008192680.1 188 2.0e-11 PREDICTED: muscle LIM protein Mlp84B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24400 137 6.6e-07 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32744 BF_2 375.18 1.71 9449 642926969 XP_008195083.1 2249 1.0e-249 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X1 [Tribolium castaneum]>gi|642926971|ref|XP_008195084.1| PREDICTED: rho guanine nucleotide exchange factor 18 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.0e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF06206//PF00621//PF05791//PF03650//PF10186//PF08031 CpeT/CpcT family (DUF1001)//RhoGEF domain//Bacillus haemolytic enterotoxin (HBL)//Uncharacterised protein family (UPF0041)//Vacuolar sorting 38 and autophagy-related subunit 14//Berberine and berberine like GO:0055114//GO:0017009//GO:0010508//GO:0043087//GO:0006850//GO:0035023//GO:0009405 oxidation-reduction process//protein-phycocyanobilin linkage//positive regulation of autophagy//regulation of GTPase activity//mitochondrial pyruvate transport//regulation of Rho protein signal transduction//pathogenesis GO:0005089//GO:0050660//GO:0016491 Rho guanyl-nucleotide exchange factor activity//flavin adenine dinucleotide binding//oxidoreductase activity GO:0016020//GO:0005743 membrane//mitochondrial inner membrane -- -- Cluster-8309.32746 BF_2 72.32 2.13 1705 91084999 XP_973197.1 1693 5.4e-186 PREDICTED: TBC1 domain family member 10A [Tribolium castaneum]>gi|270009019|gb|EFA05467.1| hypothetical protein TcasGA2_TC015650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BHL3 888 4.9e-94 TBC1 domain family member 10B OS=Mus musculus GN=Tbc1d10b PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634//GO:0005622 nucleus//intracellular KOG2221 PDZ-domain interacting protein EPI64, contains TBC domain Cluster-8309.32747 BF_2 1126.38 27.90 1976 642916102 XP_971729.2 1781 3.9e-196 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5E9I8 1238 1.5e-134 DDB1- and CUL4-associated factor 11 OS=Bos taurus GN=DCAF11 PE=2 SV=1 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0266 WD40 repeat-containing protein Cluster-8309.32748 BF_2 656.00 59.81 746 91077450 XP_967239.1 323 1.7e-27 PREDICTED: guanine nucleotide-binding protein subunit gamma-1 [Tribolium castaneum]>gi|270002133|gb|EEZ98580.1| hypothetical protein TcasGA2_TC001094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P38040 231 3.3e-18 Guanine nucleotide-binding protein subunit gamma-1 OS=Drosophila melanogaster GN=Ggamma1 PE=2 SV=1 PF00631 GGL domain GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-8309.32751 BF_2 279.93 2.68 4653 270012482 EFA08930.1 2066 8.2e-229 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 992 1.2e-105 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.32752 BF_2 44.01 0.39 5009 270012482 EFA08930.1 2066 8.8e-229 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 992 1.3e-105 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.32753 BF_2 332.29 6.24 2515 642935097 XP_008197884.1 1820 1.5e-200 PREDICTED: probable RNA methyltransferase bin3 isoform X1 [Tribolium castaneum]>gi|270013396|gb|EFA09844.1| hypothetical protein TcasGA2_TC011992 [Tribolium castaneum] -- -- -- -- -- K15190 MEPCE, BCDIN3 7SK snRNA methylphosphate capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15190 Q8K3A9 597 4.0e-60 7SK snRNA methylphosphate capping enzyme OS=Mus musculus GN=Mepce PE=1 SV=2 PF05958//PF08241//PF02390//PF05175//PF03810//PF01135//PF08123//PF05401//PF06859 tRNA (Uracil-5-)-methyltransferase//Methyltransferase domain//Putative methyltransferase//Methyltransferase small domain//Importin-beta N-terminal domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Histone methylation protein DOT1//Nodulation protein S (NodS)//Bicoid-interacting protein 3 (Bin3) GO:0009877//GO:0009451//GO:0006479//GO:0006400//GO:0046500//GO:0008152//GO:0008033//GO:0006396//GO:0006554//GO:0006464//GO:0009312//GO:0006886 nodulation//RNA modification//protein methylation//tRNA modification//S-adenosylmethionine metabolic process//metabolic process//tRNA processing//RNA processing//lysine catabolic process//cellular protein modification process//oligosaccharide biosynthetic process//intracellular protein transport GO:0008176//GO:0004719//GO:0018024//GO:0008757//GO:0008536//GO:0008173//GO:0008168 tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//histone-lysine N-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//Ran GTPase binding//RNA methyltransferase activity//methyltransferase activity -- -- KOG2899 Predicted methyltransferase Cluster-8309.32754 BF_2 160.00 5.68 1466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32755 BF_2 698.00 15.36 2188 546676390 ERL87412.1 1604 1.4e-175 hypothetical protein D910_04807 [Dendroctonus ponderosae] -- -- -- -- -- K18726 FAF2, UBXD8 FAS-associated factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18726 Q28BP9 840 2.3e-88 FAS-associated factor 2 OS=Xenopus tropicalis GN=faf2 PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.32756 BF_2 3916.94 27.79 6183 642911068 XP_008200561.1 1643 1.2e-179 PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum]>gi|642911070|ref|XP_008200562.1| PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum] 642911069 XM_008202340.1 599 0 PREDICTED: Tribolium castaneum ELAV-like protein 4 (LOC659897), transcript variant X2, mRNA K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 Q28GD4 1057 4.5e-113 ELAV-like protein 2 OS=Xenopus tropicalis GN=elavl2 PE=2 SV=2 PF08675//PF00076//PF16367//PF08777 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.32761 BF_2 3020.07 12.45 10435 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436//PF07442 NHL repeat//Ponericin -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.32764 BF_2 983.15 33.31 1522 478251030 ENN71511.1 1526 1.1e-166 hypothetical protein YQE_11804, partial [Dendroctonus ponderosae]>gi|546679470|gb|ERL89934.1| hypothetical protein D910_07293 [Dendroctonus ponderosae] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q9NP80 974 4.7e-104 Calcium-independent phospholipase A2-gamma OS=Homo sapiens GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.32766 BF_2 766.00 38.34 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32767 BF_2 384.82 4.78 3654 91084659 XP_967590.1 881 1.7e-91 PREDICTED: protein GUCD1 isoform X2 [Tribolium castaneum]>gi|270008923|gb|EFA05371.1| hypothetical protein TcasGA2_TC015537 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 1.5e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284//PF03412 Cytochrome c oxidase subunit Va//Peptidase C39 family GO:0006123//GO:0015992//GO:0006508 mitochondrial electron transport, cytochrome c to oxygen//proton transport//proteolysis GO:0005524//GO:0008233//GO:0004129 ATP binding//peptidase activity//cytochrome-c oxidase activity GO:0045277//GO:0005743//GO:0016021 respiratory chain complex IV//mitochondrial inner membrane//integral component of membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.32769 BF_2 4.00 1.98 369 390369787 XP_003731711.1 236 1.0e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 198 1.1e-14 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.32770 BF_2 760.13 27.02 1464 91093034 XP_970412.1 1010 7.3e-107 PREDICTED: transmembrane protein 183 [Tribolium castaneum]>gi|270002700|gb|EEZ99147.1| hypothetical protein TcasGA2_TC012928 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R8D5 475 3.3e-46 Transmembrane protein 183 OS=Pongo abelii GN=TMEM183 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32774 BF_2 911.33 6.00 6640 270007202 EFA03650.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013744 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.90452e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 O88477 954 4.2e-101 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Mus musculus GN=Igf2bp1 PE=1 SV=1 PF00076//PF07650//PF04061//PF00013//PF13014//PF13184 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//KH domain//ORMDL family//KH domain//KH domain//NusA-like KH domain -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.32778 BF_2 348.05 5.56 2906 270004742 EFA01190.1 2041 4.1e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 9.6e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006525//GO:0006560//GO:0071436//GO:0006090//GO:0006814 arginine metabolic process//proline metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.32779 BF_2 118.46 2.15 2591 91092388 XP_968476.1 2123 1.1e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.11497e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32781 BF_2 49.15 0.81 2840 642927136 XP_972282.2 1000 2.0e-105 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 273 1.7e-22 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593//PF00858 Flavin containing amine oxidoreductase//Amiloride-sensitive sodium channel GO:0006814//GO:0055114 sodium ion transport//oxidation-reduction process GO:0005272//GO:0016491 sodium channel activity//oxidoreductase activity GO:0016020 membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.32783 BF_2 46.39 0.52 4029 270007709 EFA04157.1 2799 0.0e+00 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1117 3.2e-120 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF13304//PF00664//PF03193//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.32787 BF_2 398.84 13.71 1504 91086851 XP_974311.1 638 1.0e-63 PREDICTED: vacuolar protein-sorting-associated protein 25 [Tribolium castaneum]>gi|270010461|gb|EFA06909.1| hypothetical protein TcasGA2_TC009858 [Tribolium castaneum] -- -- -- -- -- K12189 VPS25, EAP20 ESCRT-II complex subunit VPS25 http://www.genome.jp/dbget-bin/www_bget?ko:K12189 Q6NWF4 431 4.2e-41 Vacuolar protein-sorting-associated protein 25 OS=Danio rerio GN=vps25 PE=2 SV=2 PF07749 Endoplasmic reticulum protein ERp29, C-terminal domain -- -- -- -- GO:0005783 endoplasmic reticulum KOG4068 Uncharacterized conserved protein Cluster-8309.32790 BF_2 97.98 1.00 4398 270014340 EFA10788.1 1021 1.2e-107 hypothetical protein TcasGA2_TC012758 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 444 3.8e-42 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.32791 BF_2 672.79 8.07 3776 512892422 XP_004922927.1 1009 2.5e-106 PREDICTED: uncharacterized protein LOC101739908 [Bombyx mori] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 388 1.0e-35 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.32792 BF_2 178.00 5.61 1615 91083221 XP_973529.1 638 1.1e-63 PREDICTED: DNA replication complex GINS protein SLD5 [Tribolium castaneum]>gi|270006961|gb|EFA03409.1| hypothetical protein TcasGA2_TC013396 [Tribolium castaneum] -- -- -- -- -- K10735 GINS4, SLD5 GINS complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10735 Q99LZ3 407 2.8e-38 DNA replication complex GINS protein SLD5 OS=Mus musculus GN=Gins4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3176 Predicted alpha-helical protein, potentially involved in replication/repair Cluster-8309.32793 BF_2 792.28 6.47 5409 642929544 XP_975258.3 1155 4.1e-123 PREDICTED: KH domain-containing, RNA-binding, signal transduction-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q5VWX1 417 6.4e-39 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Homo sapiens GN=KHDRBS2 PE=1 SV=1 PF13014//PF00013//PF06667 KH domain//KH domain//Phage shock protein B GO:0006355//GO:0009271 regulation of transcription, DNA-templated//phage shock GO:0003723 RNA binding -- -- -- -- Cluster-8309.32794 BF_2 114.71 3.27 1754 478250772 ENN71264.1 1759 1.2e-193 hypothetical protein YQE_12190, partial [Dendroctonus ponderosae] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1207 5.1e-131 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0339 ATP-dependent RNA helicase Cluster-8309.32795 BF_2 211.92 2.08 4549 642910503 XP_008200242.1 2679 6.6e-300 PREDICTED: phospholipase DDHD2 isoform X1 [Tribolium castaneum] 826487484 XM_012683938.1 80 6.97887e-31 PREDICTED: Monomorium pharaonis SEC23-interacting protein-like (LOC105838396), transcript variant X4, mRNA -- -- -- -- Q9Y6Y8 1018 1.1e-108 SEC23-interacting protein OS=Homo sapiens GN=SEC23IP PE=1 SV=1 PF13724//PF02862 DNA-binding domain//DDHD domain -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.32796 BF_2 1584.61 37.35 2062 91092312 XP_969869.1 565 4.1e-55 PREDICTED: transcriptional regulator DEF1 [Tribolium castaneum]>gi|270015692|gb|EFA12140.1| hypothetical protein TcasGA2_TC002287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32797 BF_2 291.62 7.50 1914 91081331 XP_970657.1 567 2.2e-55 PREDICTED: Krueppel homolog 2 [Tribolium castaneum]>gi|270005195|gb|EFA01643.1| hypothetical protein TcasGA2_TC007213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V447 370 6.4e-34 Krueppel homolog 2 OS=Drosophila melanogaster GN=Kr-h2 PE=1 SV=1 PF03661 Uncharacterised protein family (UPF0121) -- -- -- -- GO:0016021 integral component of membrane KOG4002 Uncharacterized integral membrane protein Cluster-8309.32798 BF_2 12.00 0.76 948 241616200 XP_002407917.1 688 1.0e-69 cyclophilin A, putative [Ixodes scapularis]>gi|215502877|gb|EEC12371.1| cyclophilin A, putative [Ixodes scapularis] 657815018 XM_008336453.1 131 6.30659e-60 PREDICTED: Cynoglossus semilaevis peptidyl-prolyl cis-trans isomerase-like (LOC103397984), mRNA K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P25007 651 8.2e-67 Peptidyl-prolyl cis-trans isomerase OS=Drosophila melanogaster GN=Cyp1 PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.328 BF_2 9.69 0.54 1034 270007707 EFA04155.1 1408 3.6e-153 hypothetical protein TcasGA2_TC014400 [Tribolium castaneum] 170055942 XM_001863773.1 194 6.56661e-95 Culex quinquefasciatus lim homeobox protein, mRNA K09374 LHX3_4 LIM homeobox protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K09374 Q90421 860 5.2e-91 LIM/homeobox protein Lhx3 OS=Danio rerio GN=lhx3 PE=2 SV=1 PF00046//PF05920//PF00412 Homeobox domain//Homeobox KN domain//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.3280 BF_2 2.00 0.35 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32801 BF_2 434.81 2.18 8629 270011427 EFA07875.1 6305 0.0e+00 hypothetical protein TcasGA2_TC005449 [Tribolium castaneum] 642933139 XM_008199051.1 245 2.51352e-122 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 3.2e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF06333//PF14672//PF02671 Mediator complex subunit 13 C-terminal//Late cornified envelope//Paired amphipathic helix repeat GO:0008544//GO:0006355//GO:0006357 epidermis development//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.32804 BF_2 44.43 0.77 2686 642935171 XP_008199676.1 280 5.9e-22 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q9JLJ5 169 1.8e-10 Elongation of very long chain fatty acids protein 1 OS=Mus musculus GN=Elovl1 PE=2 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32805 BF_2 922.79 11.89 3534 389611375 BAM19299.1 995 9.6e-105 elongase [Papilio polytes] 642935170 XM_008201454.1 67 9.1159e-24 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein AAEL008004 (LOC655397), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 726 6.2e-75 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32806 BF_2 159.71 0.97 7150 642933564 XP_008197473.1 1589 2.6e-173 PREDICTED: serine-enriched protein isoform X6 [Tribolium castaneum] 749773347 XM_011143789.1 272 2.03716e-137 PREDICTED: Harpegnathos saltator serine-enriched protein-like (LOC105184770), partial mRNA -- -- -- -- O61366 1396 2.5e-152 Serine-enriched protein OS=Drosophila melanogaster GN=gprs PE=3 SV=3 PF00651//PF02214 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.32807 BF_2 750.00 31.13 1295 91091954 XP_968265.1 1695 2.4e-186 PREDICTED: eukaryotic translation initiation factor 3 subunit M [Tribolium castaneum]>gi|270000777|gb|EEZ97224.1| hypothetical protein TcasGA2_TC011022 [Tribolium castaneum] 766938025 XM_011503194.1 111 1.14031e-48 PREDICTED: Ceratosolen solmsi marchali eukaryotic translation initiation factor 3 subunit M (LOC105365102), mRNA K15030 EIF3M translation initiation factor 3 subunit M http://www.genome.jp/dbget-bin/www_bget?ko:K15030 Q17D30 1397 3.5e-153 Eukaryotic translation initiation factor 3 subunit M OS=Aedes aegypti GN=AAEL004347 PE=3 SV=1 PF02637//PF01399 GatB domain//PCI domain -- -- GO:0016884//GO:0005515 carbon-nitrogen ligase activity, with glutamine as amido-N-donor//protein binding -- -- KOG2753 Uncharacterized conserved protein, contains PCI domain Cluster-8309.32808 BF_2 31.33 0.42 3434 642935023 XP_008199910.1 1215 2.9e-130 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 770 4.7e-80 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF08925//PF16367//PF11547//PF00076 Domain of Unknown Function (DUF1907)//RNA recognition motif//E3 ubiquitin ligase EDD//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0043130 nucleic acid binding//ubiquitin binding GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.32809 BF_2 237.99 8.87 1410 237681162 NP_001153726.1 927 2.9e-97 glyoxylate reductase/hydroxypyruvate reductase-like [Tribolium castaneum]>gi|270012386|gb|EFA08834.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC006532 [Tribolium castaneum] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q91Z53 551 4.8e-55 Glyoxylate reductase/hydroxypyruvate reductase OS=Mus musculus GN=Grhpr PE=1 SV=1 PF03446//PF00899//PF02826//PF00389 NAD binding domain of 6-phosphogluconate dehydrogenase//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain GO:0055114//GO:0019521//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//metabolic process//pentose-phosphate shunt GO:0048037//GO:0008641//GO:0004616//GO:0000166//GO:0051287//GO:0016616 cofactor binding//small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.32811 BF_2 333.03 17.18 1098 642913868 XP_008201196.1 827 9.0e-86 PREDICTED: leucine-rich repeat-containing protein C10orf11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D9B4 539 9.2e-54 Leucine-rich repeat-containing protein C10orf11 homolog OS=Mus musculus PE=2 SV=1 PF02963//PF13855//PF05955//PF00560 Restriction endonuclease EcoRI//Leucine rich repeat//Equine herpesvirus glycoprotein gp2//Leucine Rich Repeat GO:0006308//GO:0009307//GO:0016032 DNA catabolic process//DNA restriction-modification system//viral process GO:0000287//GO:0005515//GO:0003677//GO:0009036 magnesium ion binding//protein binding//DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359//GO:0016021 Type II site-specific deoxyribonuclease complex//integral component of membrane KOG1644 U2-associated snRNP A' protein Cluster-8309.32812 BF_2 702.40 5.62 5514 91092090 XP_971602.1 1246 1.2e-133 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 Q0P678 341 4.2e-30 Zinc finger CCCH domain-containing protein 18 OS=Mus musculus GN=Zc3h18 PE=1 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.32814 BF_2 127.47 4.02 1613 478249963 ENN70470.1 498 1.9e-47 hypothetical protein YQE_12973, partial [Dendroctonus ponderosae] -- -- -- -- -- K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q9H000 401 1.4e-37 Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens GN=MKRN2 PE=1 SV=2 PF14634//PF08152//PF15332//PF17123//PF12678//PF00097//PF13639//PF12861//PF00642 zinc-RING finger domain//GUCT (NUC152) domain//Lck-interacting transmembrane adapter 1//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0050853//GO:0050852//GO:0016567 B cell receptor signaling pathway//T cell receptor signaling pathway//protein ubiquitination GO:0008270//GO:0046872//GO:0005524//GO:0003723//GO:0004386//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ATP binding//RNA binding//helicase activity//ubiquitin-protein transferase activity//protein binding GO:0005634//GO:0005680 nucleus//anaphase-promoting complex -- -- Cluster-8309.32817 BF_2 230.00 6.20 1839 642935974 XP_008198253.1 1686 3.8e-185 PREDICTED: inositol-trisphosphate 3-kinase A isoform X2 [Tribolium castaneum]>gi|270013997|gb|EFA10445.1| hypothetical protein TcasGA2_TC012691 [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P17105 586 5.5e-59 Inositol-trisphosphate 3-kinase A OS=Rattus norvegicus GN=Itpka PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.32819 BF_2 1000.51 22.05 2185 642918045 XP_008198993.1 696 2.8e-70 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9B9 423 5.2e-40 Choline transporter-like protein 1 OS=Torpedo marmorata GN=slc44a1 PE=1 SV=1 PF05786//PF06350 Condensin complex subunit 2//Hormone-sensitive lipase (HSL) N-terminus GO:0016042//GO:0007076//GO:0008203 lipid catabolic process//mitotic chromosome condensation//cholesterol metabolic process GO:0016298 lipase activity GO:0000796 condensin complex KOG1362 Choline transporter-like protein Cluster-8309.32822 BF_2 25.73 0.47 2574 546684338 ERL94043.1 1089 8.8e-116 hypothetical protein D910_11326 [Dendroctonus ponderosae] -- -- -- -- -- K00008 SORD, gutB L-iditol 2-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00008 Q64442 730 1.5e-75 Sorbitol dehydrogenase OS=Mus musculus GN=Sord PE=1 SV=3 PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG0024 Sorbitol dehydrogenase Cluster-8309.32823 BF_2 30.00 2.70 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32826 BF_2 91.00 4.80 1080 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32828 BF_2 675.36 13.89 2321 642919704 XP_008192030.1 434 7.1e-40 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15925 SOSS complex subunit C GO:0006974//GO:0006281 cellular response to DNA damage stimulus//DNA repair GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0005634//GO:0070876 nucleus//SOSS complex -- -- Cluster-8309.32829 BF_2 30.36 0.50 2836 91081249 XP_975650.1 638 1.9e-63 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q5ZKN2 387 1.0e-35 Membrane-associated progesterone receptor component 1 OS=Gallus gallus GN=PGRMC1 PE=2 SV=3 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.32830 BF_2 123.64 1.55 3629 755951729 XP_011301857.1 550 3.9e-53 PREDICTED: guanine nucleotide-binding protein subunit beta-like protein isoform X2 [Fopius arisanus] -- -- -- -- -- K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 502 6.0e-49 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.32834 BF_2 371.00 7.89 2255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32835 BF_2 38.26 0.47 3722 642939572 XP_008200536.1 588 1.6e-57 PREDICTED: uncharacterized protein LOC103314960 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32836 BF_2 255.56 8.05 1615 91085165 XP_970735.1 1533 1.8e-167 PREDICTED: septin-1 [Tribolium castaneum]>gi|270008471|gb|EFA04919.1| hypothetical protein TcasGA2_TC014984 [Tribolium castaneum] 213514885 NM_001140440.1 121 3.94765e-54 Salmo salar septin 2 (sept2), mRNA >gnl|BL_ORD_ID|5992956 Salmo salar clone ssal-rgf-535-071 Septin-2 putative mRNA, complete cds K16942 SEPT2 septin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16942 P42207 1401 1.5e-153 Septin-1 OS=Drosophila melanogaster GN=Sep1 PE=1 SV=1 PF00005//PF03193//PF04670//PF01580//PF04548//PF00071//PF08477//PF00735//PF01926//PF05049 ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//FtsK/SpoIIIE family//AIG1 family//Ras family//Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//Interferon-inducible GTPase (IIGP) GO:0007264//GO:0007049 small GTPase mediated signal transduction//cell cycle GO:0005525//GO:0000166//GO:0016887//GO:0003924//GO:0005524//GO:0003677 GTP binding//nucleotide binding//ATPase activity//GTPase activity//ATP binding//DNA binding GO:0031105//GO:0016020 septin complex//membrane -- -- Cluster-8309.32838 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32839 BF_2 239.07 4.93 2315 91083675 XP_968367.1 1831 7.3e-202 PREDICTED: serine/threonine-protein kinase PINK1, mitochondrial [Tribolium castaneum]>gi|270006820|gb|EFA03268.1| hypothetical protein TcasGA2_TC013202 [Tribolium castaneum] -- -- -- -- -- K05688 PINK1 PTEN induced putative kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05688 Q9BXM7 729 1.8e-75 Serine/threonine-protein kinase PINK1, mitochondrial OS=Homo sapiens GN=PINK1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG4158 BRPK/PTEN-induced protein kinase Cluster-8309.32840 BF_2 99.30 0.43 10005 642918656 XP_008191524.1 2229 2.2e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.5e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF07535//PF06220//PF00433//PF13520//PF00463//PF01799//PF07714//PF00069 DBF zinc finger//U1 zinc finger//Protein kinase C terminal domain//Amino acid permease//Isocitrate lyase family//[2Fe-2S] binding domain//Protein tyrosine kinase//Protein kinase domain GO:0003333//GO:0006865//GO:0019752//GO:0016310//GO:0006097//GO:0055114//GO:0009069//GO:0006468 amino acid transmembrane transport//amino acid transport//carboxylic acid metabolic process//phosphorylation//glyoxylate cycle//oxidation-reduction process//serine family amino acid metabolic process//protein phosphorylation GO:0003676//GO:0004672//GO:0046872//GO:0016491//GO:0004451//GO:0005543//GO:0008270//GO:0004674//GO:0015171//GO:0005524 nucleic acid binding//protein kinase activity//metal ion binding//oxidoreductase activity//isocitrate lyase activity//phospholipid binding//zinc ion binding//protein serine/threonine kinase activity//amino acid transmembrane transporter activity//ATP binding GO:0016020 membrane KOG0690 Serine/threonine protein kinase Cluster-8309.32842 BF_2 14.98 0.47 1625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08107 Pleurocidin family GO:0042742 defense response to bacterium -- -- -- -- -- -- Cluster-8309.32843 BF_2 324.40 19.31 990 642931867 XP_008196761.1 474 7.0e-45 PREDICTED: 46 kDa FK506-binding nuclear protein [Tribolium castaneum]>gi|270011711|gb|EFA08159.1| hypothetical protein TcasGA2_TC005779 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q26486 441 1.9e-42 46 kDa FK506-binding nuclear protein OS=Spodoptera frugiperda GN=FKBP46 PE=2 SV=1 PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase GO:0000412//GO:0006457 histone peptidyl-prolyl isomerization//protein folding GO:0005528//GO:0003755 FK506 binding//peptidyl-prolyl cis-trans isomerase activity GO:0005730 nucleolus KOG0552 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.32844 BF_2 248.21 5.66 2121 91089541 XP_971419.1 818 1.9e-84 PREDICTED: protein canopy 4 [Tribolium castaneum]>gi|270012595|gb|EFA09043.1| hypothetical protein TcasGA2_TC006756 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2L6K8 520 2.9e-51 Protein canopy 4 OS=Danio rerio GN=cnpy4 PE=2 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- KOG4052 Uncharacterized conserved protein Cluster-8309.32845 BF_2 204.79 3.04 3101 751797551 XP_011208646.1 373 1.1e-32 PREDICTED: 39 kDa FK506-binding nuclear protein [Bactrocera dorsalis] -- -- -- -- -- K14826 FPR3_4 FK506-binding nuclear protein http://www.genome.jp/dbget-bin/www_bget?ko:K14826 Q26486 368 1.8e-33 46 kDa FK506-binding nuclear protein OS=Spodoptera frugiperda GN=FKBP46 PE=2 SV=1 PF08052//PF00254 PyrBI operon leader peptide//FKBP-type peptidyl-prolyl cis-trans isomerase GO:0019856//GO:0006457 pyrimidine nucleobase biosynthetic process//protein folding -- -- -- -- KOG0552 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.32846 BF_2 473.80 3.56 5859 642914541 XP_008201720.1 2081 1.9e-230 PREDICTED: organic cation transporter protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 857 6.6e-90 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083//PF04847 Major Facilitator Superfamily//Sugar (and other) transporter//Calcipressin GO:0055085//GO:0019722 transmembrane transport//calcium-mediated signaling GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.32847 BF_2 78.39 3.77 1157 91093175 XP_968014.1 866 2.9e-90 PREDICTED: ankyrin repeat domain-containing protein 29 [Tribolium castaneum]>gi|270012951|gb|EFA09399.1| hypothetical protein TcasGA2_TC004317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502M6 439 3.8e-42 Ankyrin repeat domain-containing protein 29 OS=Danio rerio GN=ankrd29 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32848 BF_2 55.00 7.91 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32850 BF_2 517.27 7.06 3353 91093162 XP_967461.1 1758 3.1e-193 PREDICTED: nucleolar complex protein 4 homolog B [Tribolium castaneum]>gi|270012948|gb|EFA09396.1| hypothetical protein TcasGA2_TC004314 [Tribolium castaneum] -- -- -- -- -- K14771 NOC4, UTP19 U3 small nucleolar RNA-associated protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K14771 Q6NRQ2 650 3.8e-66 Nucleolar complex protein 4 homolog A OS=Xenopus laevis GN=noc4l-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2154 Predicted nucleolar protein involved in ribosome biogenesis Cluster-8309.32851 BF_2 1683.94 27.23 2874 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08127 Peptidase family C1 propeptide GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.32852 BF_2 532.00 17.47 1561 189235436 XP_001812776.1 872 7.8e-91 PREDICTED: protein twisted gastrulation [Tribolium castaneum]>gi|270004290|gb|EFA00738.1| hypothetical protein TcasGA2_TC003620 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54356 495 1.7e-48 Protein twisted gastrulation OS=Drosophila melanogaster GN=tsg PE=1 SV=1 PF03627 PapG carbohydrate binding domain GO:0007155 cell adhesion GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.32853 BF_2 14.38 2.39 539 642915809 XP_008200087.1 163 4.4e-09 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.32854 BF_2 8.88 0.58 924 478262344 ENN81050.1 347 3.5e-30 hypothetical protein YQE_02544, partial [Dendroctonus ponderosae]>gi|546686568|gb|ERL95746.1| hypothetical protein D910_00204 [Dendroctonus ponderosae]>gi|546687019|gb|ERL95951.1| hypothetical protein D910_00665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P2X9 154 3.4e-09 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32855 BF_2 1834.60 33.96 2547 189234663 XP_969172.2 1961 6.7e-217 PREDICTED: monocarboxylate transporter 10 [Tribolium castaneum]>gi|642914047|ref|XP_008201523.1| PREDICTED: monocarboxylate transporter 10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K1C7 300 1.1e-25 Monocarboxylate transporter 14 OS=Mus musculus GN=Slc16a14 PE=2 SV=1 PF02308//PF07690 MgtC family//Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.32856 BF_2 112.17 6.57 1001 91090398 XP_970402.1 897 6.3e-94 PREDICTED: mediator of RNA polymerase II transcription subunit 19 [Tribolium castaneum]>gi|270013384|gb|EFA09832.1| hypothetical protein TcasGA2_TC011979 [Tribolium castaneum] 665785746 XM_008550626.1 219 8.04164e-109 PREDICTED: Microplitis demolitor mediator of RNA polymerase II transcription subunit 19 (LOC103572159), mRNA K15137 MED19 mediator of RNA polymerase II transcription subunit 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15137 Q174D3 697 4.0e-72 Mediator of RNA polymerase II transcription subunit 19 OS=Aedes aegypti GN=MED19 PE=3 SV=1 PF06459//PF10278//PF02932 Ryanodine Receptor TM 4-6//Mediator of RNA pol II transcription subunit 19//Neurotransmitter-gated ion-channel transmembrane region GO:0006357//GO:0006874//GO:0006811//GO:0006816 regulation of transcription from RNA polymerase II promoter//cellular calcium ion homeostasis//ion transport//calcium ion transport GO:0001104//GO:0005219 RNA polymerase II transcription cofactor activity//ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016020//GO:0016592//GO:0016021 intracellular//membrane//mediator complex//integral component of membrane -- -- Cluster-8309.32859 BF_2 40.97 0.75 2577 91079134 XP_975446.1 905 1.9e-94 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|642916464|ref|XP_008191038.1| PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270004224|gb|EFA00672.1| hypothetical protein TcasGA2_TC003549 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q58DT4 469 2.8e-45 Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Bos taurus GN=PYCR1 PE=2 SV=1 PF03446//PF01408 NAD binding domain of 6-phosphogluconate dehydrogenase//Oxidoreductase family, NAD-binding Rossmann fold GO:0055114//GO:0019521//GO:0006561//GO:0006098//GO:0055129//GO:0006525 oxidation-reduction process//D-gluconate metabolic process//proline biosynthetic process//pentose-phosphate shunt//L-proline biosynthetic process//arginine metabolic process GO:0004616//GO:0000166//GO:0016491//GO:0004735 phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding//oxidoreductase activity//pyrroline-5-carboxylate reductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.32860 BF_2 2328.25 60.02 1910 332374070 AEE62176.1 1079 9.5e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9SU79 406 4.3e-38 Probable polyamine oxidase 5 OS=Arabidopsis thaliana GN=PAO5 PE=2 SV=1 PF07992//PF12831//PF01593 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.32861 BF_2 722.71 17.84 1982 332374070 AEE62176.1 1079 9.8e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9SU79 406 4.4e-38 Probable polyamine oxidase 5 OS=Arabidopsis thaliana GN=PAO5 PE=2 SV=1 PF01593//PF12831//PF07992 Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.32862 BF_2 214.72 1.29 7243 91076984 XP_975463.1 1357 2.1e-146 PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913260|ref|XP_008201461.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913262|ref|XP_008201462.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|270001993|gb|EEZ98440.1| hypothetical protein TcasGA2_TC000929 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97379 370 2.4e-33 Ras GTPase-activating protein-binding protein 2 OS=Mus musculus GN=G3bp2 PE=1 SV=2 PF00076//PF15886//PF16367//PF02136 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Carbohydrate binding domain (family 32)//RNA recognition motif//Nuclear transport factor 2 (NTF2) domain GO:0006810 transport GO:0003676//GO:0030246 nucleic acid binding//carbohydrate binding GO:0005622 intracellular KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains Cluster-8309.32864 BF_2 44.04 1.42 1581 642927136 XP_972282.2 850 2.8e-88 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9SU79 285 3.8e-24 Probable polyamine oxidase 5 OS=Arabidopsis thaliana GN=PAO5 PE=2 SV=1 PF07992//PF01593//PF12831 Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.32865 BF_2 172.86 7.18 1294 642924152 XP_008194029.1 432 6.8e-40 PREDICTED: endothelin-converting enzyme-like 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.32866 BF_2 111.50 3.30 1702 134131322 BAF49604.1 483 1.1e-45 chitinase [Monochamus alternatus] -- -- -- -- -- K17523 CHI3L1_2 chitinase-3-like protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17523 P36362 245 1.8e-19 Endochitinase OS=Manduca sexta PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.32867 BF_2 353.93 9.26 1886 170321839 BAG14264.1 714 2.0e-72 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8CFG8 240 7.5e-19 Complement C1s-B subcomponent OS=Mus musculus GN=C1sb PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.32869 BF_2 65.56 1.01 2991 642924917 XP_008194096.1 3268 0.0e+00 PREDICTED: neprilysin-2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08635 MMEL1 membrane metallo-endopeptidase-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08635 O16796 1289 2.7e-140 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.32870 BF_2 543.37 7.48 3328 282720985 NP_001164243.1 2817 0.0e+00 angiotensin-converting enzyme 3 precursor [Tribolium castaneum]>gi|270015941|gb|EFA12389.1| Ance-3 [Tribolium castaneum] -- -- -- -- -- K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 1438 1.6e-157 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.32873 BF_2 155.00 2.28 3129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32874 BF_2 58.67 0.39 6546 91082437 XP_970911.1 820 3.5e-84 PREDICTED: tribbles homolog 2 [Tribolium castaneum] 645019257 XM_001600513.3 42 1.339e-09 PREDICTED: Nasonia vitripennis tribbles homolog 2-like (LOC100115993), mRNA K08814 TRIB1_2 tribbles homolog 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08814 Q5R669 460 8.0e-44 Tribbles homolog 2 OS=Pongo abelii GN=TRIB2 PE=2 SV=1 PF00069//PF07714//PF08755//PF03283//PF00539 Protein kinase domain//Protein tyrosine kinase//Hemimethylated DNA-binding protein YccV like//Pectinacetylesterase//Transactivating regulatory protein (Tat) GO:0006468//GO:0006355 protein phosphorylation//regulation of transcription, DNA-templated GO:0005524//GO:0016787//GO:0003677//GO:0003700//GO:0004672 ATP binding//hydrolase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//protein kinase activity GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG0583 Serine/threonine protein kinase Cluster-8309.32875 BF_2 1155.75 4.69 10603 270014310 EFA10758.1 3865 0.0e+00 starry night [Tribolium castaneum] 332376259 BT128312.1 203 6.88289e-99 Dendroctonus ponderosae clone DPO105_N17 unknown mRNA K04600 CELSR1 cadherin EGF LAG seven-pass G-type receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04600 Q9V5N8 1132 1.5e-121 Protocadherin-like wing polarity protein stan OS=Drosophila melanogaster GN=stan PE=1 SV=4 PF00002//PF07732//PF03348//PF02421//PF00025//PF08477//PF01926//PF01825//PF02793//PF00071//PF04670//PF03193//PF00837 7 transmembrane receptor (Secretin family)//Multicopper oxidase//Serine incorporator (Serinc)//Ferrous iron transport protein B//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//GPCR proteolysis site, GPS, motif//Hormone receptor domain//Ras family//Gtr1/RagA G protein conserved region//Protein of unknown function, DUF258//Iodothyronine deiodinase GO:0015684//GO:0055114//GO:0007264//GO:0007186 ferrous iron transport//oxidation-reduction process//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0004930//GO:0005507//GO:0015093//GO:0004800//GO:0005525 GTPase activity//G-protein coupled receptor activity//copper ion binding//ferrous iron transmembrane transporter activity//thyroxine 5'-deiodinase activity//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0395 Ras-related GTPase Cluster-8309.32876 BF_2 191.00 1.94 4415 91076474 XP_972312.1 5444 0.0e+00 PREDICTED: protein toll [Tribolium castaneum]>gi|270002908|gb|EEZ99355.1| toll-7-like protein [Tribolium castaneum] 642912519 XM_967219.2 872 0 PREDICTED: Tribolium castaneum toll-7-like protein (LOC661030), mRNA -- -- -- -- O75094 449 1.0e-42 Slit homolog 3 protein OS=Homo sapiens GN=SLIT3 PE=2 SV=3 PF13855//PF01582//PF00560//PF13676 Leucine rich repeat//TIR domain//Leucine Rich Repeat//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.32877 BF_2 671.14 27.69 1301 642932482 XP_008197132.1 902 2.2e-94 PREDICTED: nucleoside diphosphate-linked moiety X motif 6 isoform X2 [Tribolium castaneum]>gi|642932484|ref|XP_008197133.1| PREDICTED: nucleoside diphosphate-linked moiety X motif 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8L7W2 380 3.0e-35 Nudix hydrolase 8 OS=Arabidopsis thaliana GN=NUDT8 PE=2 SV=2 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG0648 Predicted NUDIX hydrolase FGF-2 and related proteins Cluster-8309.32878 BF_2 110.34 3.79 1506 642932480 XP_973309.2 914 1.0e-95 PREDICTED: nudix hydrolase 8 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8L7W2 380 3.5e-35 Nudix hydrolase 8 OS=Arabidopsis thaliana GN=NUDT8 PE=2 SV=2 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG0648 Predicted NUDIX hydrolase FGF-2 and related proteins Cluster-8309.32884 BF_2 576.05 6.87 3796 642911078 XP_008200566.1 2414 3.0e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 3.4e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF13442//PF01585//PF07808//PF00641//PF00076//PF11648 Cytochrome C oxidase, cbb3-type, subunit III//G-patch domain//RED-like protein N-terminal region//Zn-finger in Ran binding protein and others//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C-terminal domain of RIG-I GO:0006118 obsolete electron transport GO:0020037//GO:0016817//GO:0008270//GO:0000166//GO:0009055//GO:0003676 heme binding//hydrolase activity, acting on acid anhydrides//zinc ion binding//nucleotide binding//electron carrier activity//nucleic acid binding GO:0005622//GO:0005634 intracellular//nucleus KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.32885 BF_2 1132.71 15.01 3443 546672307 ERL84230.1 1819 2.7e-200 hypothetical protein D910_01607 [Dendroctonus ponderosae]>gi|546672574|gb|ERL84383.1| hypothetical protein D910_01813 [Dendroctonus ponderosae] 642933834 XM_008192574.1 146 1.07769e-67 PREDICTED: Tribolium castaneum leucine-rich repeat-containing protein let-4 (LOC659033), mRNA -- -- -- -- Q8R5M3 339 4.5e-30 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF00322//PF00560//PF13855 Endothelin family//Leucine Rich Repeat//Leucine rich repeat GO:0019229 regulation of vasoconstriction GO:0005515 protein binding GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.32886 BF_2 640.69 7.23 3992 546672307 ERL84230.1 1819 3.1e-200 hypothetical protein D910_01607 [Dendroctonus ponderosae]>gi|546672574|gb|ERL84383.1| hypothetical protein D910_01813 [Dendroctonus ponderosae] 642933834 XM_008192574.1 146 1.25135e-67 PREDICTED: Tribolium castaneum leucine-rich repeat-containing protein let-4 (LOC659033), mRNA -- -- -- -- Q8R5M3 339 5.2e-30 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF00560//PF00322//PF13855 Leucine Rich Repeat//Endothelin family//Leucine rich repeat GO:0019229 regulation of vasoconstriction GO:0005515 protein binding GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.32887 BF_2 1726.67 20.10 3881 642931167 XP_969130.2 3383 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 31 [Tribolium castaneum] 194757190 XM_001960812.1 46 4.72837e-12 Drosophila ananassae GF13568 (Dana\GF13568), mRNA K11852 USP31 ubiquitin carboxyl-terminal hydrolase 31 http://www.genome.jp/dbget-bin/www_bget?ko:K11852 Q8BUM9 1056 3.7e-113 Ubiquitin carboxyl-terminal hydrolase 43 OS=Mus musculus GN=Usp43 PE=2 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.32888 BF_2 108.33 1.09 4439 642931167 XP_969130.2 3325 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 31 [Tribolium castaneum] 194757190 XM_001960812.1 46 5.41457e-12 Drosophila ananassae GF13568 (Dana\GF13568), mRNA K11852 USP31 ubiquitin carboxyl-terminal hydrolase 31 http://www.genome.jp/dbget-bin/www_bget?ko:K11852 Q8BUM9 1044 1.0e-111 Ubiquitin carboxyl-terminal hydrolase 43 OS=Mus musculus GN=Usp43 PE=2 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.32890 BF_2 32.08 0.78 2010 642936612 XP_008198506.1 556 4.4e-54 PREDICTED: uncharacterized protein LOC661523 isoform X2 [Tribolium castaneum]>gi|270013067|gb|EFA09515.1| hypothetical protein TcasGA2_TC011617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32891 BF_2 575.71 15.08 1884 642926542 XP_008194914.1 1316 3.1e-142 PREDICTED: LOW QUALITY PROTEIN: arginine-glutamic acid dipeptide repeats protein [Tribolium castaneum] 766941684 XM_011505186.1 56 6.27942e-18 PREDICTED: Ceratosolen solmsi marchali arginine-glutamic acid dipeptide repeats protein (LOC105366667), mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q80TZ9 151 1.6e-08 Arginine-glutamic acid dipeptide repeats protein OS=Mus musculus GN=Rere PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32892 BF_2 90.00 3.49 1367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32893 BF_2 79.32 1.94 2001 642926542 XP_008194914.1 1288 5.8e-139 PREDICTED: LOW QUALITY PROTEIN: arginine-glutamic acid dipeptide repeats protein [Tribolium castaneum] 766941684 XM_011505186.1 56 6.67676e-18 PREDICTED: Ceratosolen solmsi marchali arginine-glutamic acid dipeptide repeats protein (LOC105366667), mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q80TZ9 151 1.7e-08 Arginine-glutamic acid dipeptide repeats protein OS=Mus musculus GN=Rere PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32895 BF_2 397.00 7.27 2571 478253235 ENN73606.1 1674 1.3e-183 hypothetical protein YQE_09853, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SSM3 743 4.8e-77 Rho GTPase-activating protein 44 OS=Mus musculus GN=Arhgap44 PE=1 SV=1 PF03114//PF00620 BAR domain//RhoGAP domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005737 cytoplasm KOG4270 GTPase-activator protein Cluster-8309.32897 BF_2 41.00 4.26 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32899 BF_2 3181.26 19.31 7180 546676276 ERL87322.1 1518 4.4e-165 hypothetical protein D910_04717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGU5 692 1.1e-70 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF13414//PF13176//PF08515//PF07688//PF13371//PF03145//PF13374//PF00515//PF13174//PF13181 TPR repeat//Tetratricopeptide repeat//Transforming growth factor beta type I GS-motif//KaiA domain//Tetratricopeptide repeat//Seven in absentia protein family//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0016310//GO:0006468//GO:0009069//GO:0007623//GO:0007275//GO:0007178//GO:0006511 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//circadian rhythm//multicellular organismal development//transmembrane receptor protein serine/threonine kinase signaling pathway//ubiquitin-dependent protein catabolic process GO:0005515//GO:0005524//GO:0004675 protein binding//ATP binding//transmembrane receptor protein serine/threonine kinase activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.32900 BF_2 633.78 10.30 2860 91092242 XP_971366.1 2149 1.2e-238 PREDICTED: protein ariadne-2 [Tribolium castaneum]>gi|270014427|gb|EFA10875.1| hypothetical protein TcasGA2_TC001697 [Tribolium castaneum] 462373241 APGK01024814.1 200 8.56154e-98 Dendroctonus ponderosae Seq01024824, whole genome shotgun sequence K11969 ARIH2 ariadne-2 http://www.genome.jp/dbget-bin/www_bget?ko:K11969 O76924 1831 3.7e-203 Protein ariadne-2 OS=Drosophila melanogaster GN=ari-2 PE=2 SV=1 PF00097//PF14634//PF09749//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Uncharacterised conserved protein//Ring finger domain GO:0034477 U6 snRNA 3'-end processing GO:0004518//GO:0005515//GO:0046872//GO:0008270 nuclease activity//protein binding//metal ion binding//zinc ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.32902 BF_2 2095.55 80.81 1372 642914160 XP_008201571.1 601 1.8e-59 PREDICTED: muscle-specific protein 20 isoform X3 [Tribolium castaneum] 780694807 XM_011702209.1 83 4.44525e-33 PREDICTED: Wasmannia auropunctata muscle-specific protein 20-like (LOC105457507), transcript variant X2, mRNA -- -- -- -- P14318 464 5.8e-45 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.32903 BF_2 1061.75 20.32 2473 546680452 ERL90718.1 1948 2.1e-215 hypothetical protein D910_08065 [Dendroctonus ponderosae] -- -- -- -- -- K11854 USP35_38 ubiquitin carboxyl-terminal hydrolase 35/38 http://www.genome.jp/dbget-bin/www_bget?ko:K11854 Q8NB14 527 5.1e-52 Ubiquitin carboxyl-terminal hydrolase 38 OS=Homo sapiens GN=USP38 PE=1 SV=2 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.32904 BF_2 78.39 5.43 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32905 BF_2 1365.96 5.54 10602 817185266 XP_012285919.1 6615 0.0e+00 PREDICTED: neurobeachin isoform X10 [Orussus abietinus] 642919353 XM_008193614.1 1061 0 PREDICTED: Tribolium castaneum neurobeachin (LOC662147), transcript variant X2, mRNA -- -- -- -- Q9W4E2 4768 0.0e+00 Neurobeachin OS=Drosophila melanogaster GN=rg PE=1 SV=3 PF07127//PF10508//PF00400//PF15088 Late nodulin protein//Proteasome non-ATPase 26S subunit//WD domain, G-beta repeat//NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial GO:0009878//GO:0043248 nodule morphogenesis//proteasome assembly GO:0046872//GO:0005515 metal ion binding//protein binding GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.32906 BF_2 127.15 0.51 10632 817185266 XP_012285919.1 6615 0.0e+00 PREDICTED: neurobeachin isoform X10 [Orussus abietinus] 642919353 XM_008193614.1 1061 0 PREDICTED: Tribolium castaneum neurobeachin (LOC662147), transcript variant X2, mRNA -- -- -- -- Q9W4E2 4768 0.0e+00 Neurobeachin OS=Drosophila melanogaster GN=rg PE=1 SV=3 PF15088//PF00400//PF07127//PF10508 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial//WD domain, G-beta repeat//Late nodulin protein//Proteasome non-ATPase 26S subunit GO:0009878//GO:0043248 nodule morphogenesis//proteasome assembly GO:0046872//GO:0005515 metal ion binding//protein binding GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.32907 BF_2 708.06 2.95 10339 189238427 XP_973569.2 3930 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase DHX34 [Tribolium castaneum]>gi|270008523|gb|EFA04971.1| hypothetical protein TcasGA2_TC015049 [Tribolium castaneum] 642925354 XM_008196294.1 497 0 PREDICTED: Tribolium castaneum integrator complex subunit 2 (LOC661595), mRNA K13139 INTS2 integrator complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13139 Q14147 2048 9.2e-228 Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens GN=DHX34 PE=1 SV=2 PF00023//PF04851//PF03391//PF07527//PF14750//PF00270//PF04857//PF04408//PF13606//PF02399 Ankyrin repeat//Type III restriction enzyme, res subunit//Nepovirus coat protein, central domain//Hairy Orange//Integrator complex subunit 2//DEAD/DEAH box helicase//CAF1 family ribonuclease//Helicase associated domain (HA2)//Ankyrin repeat//Origin of replication binding protein GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003676//GO:0005515//GO:0008026//GO:0005198//GO:0016787//GO:0003677//GO:0003688//GO:0004386//GO:0005524 nucleic acid binding//protein binding//ATP-dependent helicase activity//structural molecule activity//hydrolase activity//DNA binding//DNA replication origin binding//helicase activity//ATP binding GO:0046809//GO:0032039//GO:0005634//GO:0019028 replication compartment//integrator complex//nucleus//viral capsid KOG4177 Ankyrin Cluster-8309.32910 BF_2 270.58 2.52 4787 642913783 XP_008201159.1 1925 1.9e-212 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.59033e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 1739 2.9e-192 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF04750//PF01562//PF10462//PF00413 FAR-17a/AIG1-like protein//Reprolysin family propeptide//Peptidase M66//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0016021//GO:0031012 integral component of membrane//extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.32911 BF_2 73.00 3.99 1053 478252267 ENN72695.1 178 1.6e-10 hypothetical protein YQE_10790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V7U0 155 3.0e-09 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32912 BF_2 97.53 0.92 4726 478252002 ENN72437.1 1353 4.0e-146 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 143 6.90217e-66 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 919 3.4e-97 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF00098//PF13014//PF00013//PF08273 Zinc knuckle//KH domain//KH domain//Zinc-binding domain of primase-helicase GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896//GO:0004386//GO:0003723//GO:0003676//GO:0008270 DNA primase activity//helicase activity//RNA binding//nucleic acid binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.32913 BF_2 957.74 28.87 1675 478252002 ENN72437.1 1609 2.9e-176 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 143 2.41431e-66 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 1084 9.0e-117 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF13014//PF00098//PF08273//PF00013 KH domain//Zinc knuckle//Zinc-binding domain of primase-helicase//KH domain GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896//GO:0003723//GO:0004386//GO:0003676//GO:0008270 DNA primase activity//RNA binding//helicase activity//nucleic acid binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.32914 BF_2 34.00 0.88 1900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02421//PF01926 Ferrous iron transport protein B//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.32918 BF_2 1191.51 54.42 1203 478254782 ENN75018.1 768 6.9e-79 hypothetical protein YQE_08333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BTX7 163 4.0e-10 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32919 BF_2 1729.59 220.67 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.32920 BF_2 36.04 0.48 3419 332375592 AEE62937.1 892 8.2e-93 unknown [Dendroctonus ponderosae]>gi|478256607|gb|ENN76789.1| hypothetical protein YQE_06630, partial [Dendroctonus ponderosae]>gi|546685197|gb|ERL94724.1| hypothetical protein D910_11998 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.32923 BF_2 413.54 15.59 1397 761901546 XP_011404925.1 340 3.4e-29 PREDICTED: uncharacterized protein LOC100639010 [Amphimedon queenslandica] -- -- -- -- -- -- -- -- -- Q1RK13 304 2.1e-26 Putative ankyrin repeat protein RBE_0220 OS=Rickettsia bellii (strain RML369-C) GN=RBE_0220 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.32924 BF_2 6333.65 99.20 2958 91077984 XP_968658.1 1421 3.2e-154 PREDICTED: serine protease 42 [Tribolium castaneum]>gi|270002734|gb|EEZ99181.1| serine protease H2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 440 7.5e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.32925 BF_2 3779.67 87.07 2103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32929 BF_2 15.05 0.38 1939 755929777 XP_011311847.1 286 8.6e-23 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Fopius arisanus] -- -- -- -- -- K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 Q3T0R7 237 1.7e-18 3-ketoacyl-CoA thiolase, mitochondrial OS=Bos taurus GN=ACAA2 PE=2 SV=1 PF02803 Thiolase, C-terminal domain GO:0008152 metabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1391 Acetyl-CoA acetyltransferase Cluster-8309.3293 BF_2 2.00 0.31 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32930 BF_2 83.05 0.33 10855 642911435 XP_008199422.1 2576 1.4e-287 PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911437|ref|XP_008199423.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911439|ref|XP_008199424.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum] -- -- -- -- -- K01349 FURIN, PCSK3 furin http://www.genome.jp/dbget-bin/www_bget?ko:K01349 P30430 1965 4.1e-218 Furin-like protease 1, isoform 1-CRR OS=Drosophila melanogaster GN=Fur1 PE=2 SV=2 PF00082//PF08496//PF01483//PF09458 Subtilase family//Peptidase family S49 N-terminal//Proprotein convertase P-domain//H-type lectin domain GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252//GO:0030246 serine-type endopeptidase activity//carbohydrate binding GO:0005886 plasma membrane KOG3525 Subtilisin-like proprotein convertase Cluster-8309.32931 BF_2 119.42 3.57 1688 642913141 XP_008201410.1 1406 1.0e-152 PREDICTED: C-5 sterol desaturase erg31-like [Tribolium castaneum] -- -- -- -- -- K00227 SC5DL, ERG3 delta7-sterol 5-desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K00227 Q7SBB6 242 3.9e-19 Probable C-5 sterol desaturase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=NCU06207 PE=3 SV=1 PF03419//PF04116 Sporulation factor SpoIIGA//Fatty acid hydroxylase superfamily GO:0055114//GO:0006508//GO:0030436//GO:0006633 oxidation-reduction process//proteolysis//asexual sporulation//fatty acid biosynthetic process GO:0016491//GO:0005506//GO:0004190 oxidoreductase activity//iron ion binding//aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.32932 BF_2 2.00 1.92 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32935 BF_2 997.69 41.83 1285 134131322 BAF49604.1 829 6.2e-86 chitinase [Monochamus alternatus] -- -- -- -- -- -- -- -- -- P36362 460 1.6e-44 Endochitinase OS=Manduca sexta PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.32936 BF_2 1786.00 2664.26 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32937 BF_2 23.82 1.47 965 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83652 196 4.8e-14 Antimicrobial peptide Alo-2 OS=Acrocinus longimanus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32940 BF_2 14.33 0.37 1897 270007545 EFA03993.1 1194 4.4e-128 hypothetical protein TcasGA2_TC014142 [Tribolium castaneum] 749793824 XM_011151919.1 98 2.83982e-41 PREDICTED: Harpegnathos saltator RNA pseudouridylate synthase domain-containing protein 2-like (LOC105189658), transcript variant X5, mRNA -- -- -- -- Q8IZ73 689 6.5e-71 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF13895//PF00849 Immunoglobulin domain//RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0005515//GO:0003723//GO:0009982 protein binding//RNA binding//pseudouridine synthase activity -- -- KOG1919 RNA pseudouridylate synthases Cluster-8309.32941 BF_2 26.00 5.15 498 38114661 AAH08955.2 233 3.1e-17 UBC protein, partial [Homo sapiens] 168028715 XM_001766821.1 87 9.24492e-36 Physcomitrella patens subsp. patens predicted protein (PHYPADRAFT_80683) mRNA, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 219 5.4e-17 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF14560//PF00240 Ubiquitin-like domain//Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.32942 BF_2 243.60 6.90 1765 642928919 XP_008195616.1 1705 2.3e-187 PREDICTED: beclin-1-like protein [Tribolium castaneum] 831317244 XM_012835846.1 40 4.60659e-09 PREDICTED: Clupea harengus beclin 1, autophagy related (becn1), transcript variant X2, mRNA K08334 BECN1, VPS30, ATG6 beclin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08334 Q9VCE1 1285 4.7e-140 Beclin-1-like protein OS=Drosophila melanogaster GN=Atg6 PE=2 SV=1 PF04111//PF07851//PF04420 Autophagy protein Apg6//TMPIT-like protein//CHD5-like protein GO:0006914//GO:0071816 autophagy//tail-anchored membrane protein insertion into ER membrane -- -- GO:0016021 integral component of membrane KOG2751 Beclin-like protein Cluster-8309.32945 BF_2 37.00 0.76 2323 642917850 XP_008191312.1 286 1.0e-22 PREDICTED: serine/threonine-protein kinase MARK2 isoform X10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32946 BF_2 37.70 0.35 4781 270013073 EFA09521.1 1113 2.7e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.6e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF00069//PF01674//PF07714 Protein kinase domain//Lipase (class 2)//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016787//GO:0004672 ATP binding//hydrolase activity//protein kinase activity -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.32947 BF_2 850.97 9.28 4124 820805532 AKG92757.1 3460 0.0e+00 helix loop helix protein 106 [Leptinotarsa decemlineata] -- -- -- -- -- K07197 SREBP1, SREBF1 sterol regulatory element-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07197 Q60416 1235 6.9e-134 Sterol regulatory element-binding protein 1 OS=Cricetulus griseus GN=SREBF1 PE=2 SV=1 PF00010//PF15898//PF01166 Helix-loop-helix DNA-binding domain//cGMP-dependent protein kinase interacting domain//TSC-22/dip/bun family GO:0006355 regulation of transcription, DNA-templated GO:0019901//GO:0003700//GO:0046983 protein kinase binding//transcription factor activity, sequence-specific DNA binding//protein dimerization activity GO:0005667 transcription factor complex KOG2588 Predicted DNA-binding protein Cluster-8309.32949 BF_2 27.69 0.34 3694 663070911 NP_001284604.1 627 4.7e-62 ras-related protein Rab-7a [Tribolium castaneum]>gi|642930896|ref|XP_008196131.1| PREDICTED: ras-related protein Rab-7a [Tribolium castaneum]>gi|629511287|gb|AHY84717.1| ras-related protein Rab-7a [Tribolium castaneum] -- -- -- -- -- K07897 RAB7A Ras-related protein Rab-7A http://www.genome.jp/dbget-bin/www_bget?ko:K07897 P09527 466 9.1e-45 Ras-related protein Rab-7a OS=Rattus norvegicus GN=Rab7a PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0394 Ras-related GTPase Cluster-8309.32950 BF_2 732.64 4.38 7285 478252889 ENN73274.1 3683 0.0e+00 hypothetical protein YQE_10104, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.8e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.32953 BF_2 1685.54 15.75 4763 642924809 XP_008194049.1 4060 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X1 [Tribolium castaneum] 749755570 XM_011141969.1 132 9.06285e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 6.0e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.32954 BF_2 543.64 3.94 6063 827549501 XP_012546855.1 724 4.4e-73 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.32955 BF_2 52.30 0.84 2904 91083299 XP_974608.1 2229 6.4e-248 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 7.1e-194 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2558 Negative regulator of histones Cluster-8309.32956 BF_2 188.68 4.88 1905 283046732 NP_001164313.1 1426 5.5e-155 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 2.0e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.32958 BF_2 37.74 0.71 2502 642923214 XP_008193658.1 1854 1.7e-204 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04360 NTRK2, TRKB neurotrophic tyrosine kinase receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04360 Q24488 711 2.4e-73 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.32959 BF_2 245.92 6.21 1945 270007066 EFA03514.1 1118 2.9e-119 hypothetical protein TcasGA2_TC013516 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 B0BNE5 821 3.3e-86 S-formylglutathione hydrolase OS=Rattus norvegicus GN=Esd PE=2 SV=1 PF12740//PF01764//PF01694//PF07819//PF00326//PF10503//PF07578//PF07224 Chlorophyllase enzyme//Lipase (class 3)//Rhomboid family//PGAP1-like protein//Prolyl oligopeptidase family//Esterase PHB depolymerase//Lipid A Biosynthesis N-terminal domain//Chlorophyllase GO:0006508//GO:0009245//GO:0015996//GO:0006505//GO:0006886//GO:0006629//GO:0015994 proteolysis//lipid A biosynthetic process//chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport//lipid metabolic process//chlorophyll metabolic process GO:0008236//GO:0008915//GO:0004252//GO:0016788//GO:0047746 serine-type peptidase activity//lipid-A-disaccharide synthase activity//serine-type endopeptidase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3101 Esterase D Cluster-8309.32960 BF_2 16.41 0.72 1237 270297202 NP_001161902.1 677 2.5e-68 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 485 1.9e-47 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.32961 BF_2 18.76 0.39 2309 91091818 XP_966528.1 932 1.3e-97 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 Q38PU3 681 6.7e-70 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007268//GO:0006810//GO:0007165//GO:0006811//GO:0044699 synaptic transmission//transport//signal transduction//ion transport//single-organism process GO:0005234//GO:0004970//GO:0004872//GO:0005230 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//receptor activity//extracellular ligand-gated ion channel activity GO:0071944//GO:0045202//GO:0016020 cell periphery//synapse//membrane -- -- Cluster-8309.32962 BF_2 1.00 17.22 220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32964 BF_2 36.00 7.84 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32965 BF_2 265.62 13.41 1116 642921560 XP_008192424.1 280 2.5e-22 PREDICTED: RISC-loading complex subunit tarbp2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09239//PF04098 Topoisomerase VI B subunit, transducer//Rad52/22 family double-strand break repair protein GO:0006310//GO:0006281//GO:0006265 DNA recombination//DNA repair//DNA topological change GO:0003918//GO:0003677 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding -- -- -- -- Cluster-8309.32966 BF_2 210.00 38.04 518 270003494 EEZ99941.1 251 2.6e-19 hypothetical protein TcasGA2_TC002737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.32967 BF_2 2812.34 29.49 4277 91077758 XP_967802.1 1416 1.8e-153 PREDICTED: fructose-1,6-bisphosphatase 1 [Tribolium castaneum]>gi|270002228|gb|EEZ98675.1| hypothetical protein TcasGA2_TC001209 [Tribolium castaneum] 229367525 BT083036.1 55 5.17859e-17 Anoplopoma fimbria clone afim-evh-526-250 Fructose-1,6-bisphosphatase 1 putative mRNA, complete cds K03841 FBP, fbp fructose-1,6-bisphosphatase I http://www.genome.jp/dbget-bin/www_bget?ko:K03841 Q3SZB7 1017 1.3e-108 Fructose-1,6-bisphosphatase 1 OS=Bos taurus GN=FBP1 PE=2 SV=3 PF13181//PF00515//PF00459//PF00316//PF13174//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Inositol monophosphatase family//Fructose-1-6-bisphosphatase//Tetratricopeptide repeat//TPR repeat GO:0006098//GO:0006096//GO:0005975//GO:0006000//GO:0046854//GO:0006013//GO:0015976//GO:0006094 pentose-phosphate shunt//glycolytic process//carbohydrate metabolic process//fructose metabolic process//phosphatidylinositol phosphorylation//mannose metabolic process//carbon utilization//gluconeogenesis GO:0042132//GO:0005515//GO:0042578 fructose 1,6-bisphosphate 1-phosphatase activity//protein binding//phosphoric ester hydrolase activity -- -- KOG1458 Fructose-1,6-bisphosphatase Cluster-8309.32968 BF_2 362.01 5.29 3151 91078902 XP_973455.1 1013 7.0e-107 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 504 3.0e-49 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF05739//PF00015//PF00804//PF08597//PF00957//PF05531//PF02561//PF04632 SNARE domain//Methyl-accepting chemotaxis protein (MCP) signalling domain//Syntaxin//Translation initiation factor eIF3 subunit//Synaptobrevin//Nucleopolyhedrovirus P10 protein//Flagellar protein FliS//Fusaric acid resistance protein family GO:0006446//GO:0016192//GO:0006810//GO:0007165 regulation of translational initiation//vesicle-mediated transport//transport//signal transduction GO:0004871//GO:0005515//GO:0003743 signal transducer activity//protein binding//translation initiation factor activity GO:0005852//GO:0005737//GO:0009288//GO:0005840//GO:0016020//GO:0016021//GO:0019028//GO:0005886 eukaryotic translation initiation factor 3 complex//cytoplasm//bacterial-type flagellum//ribosome//membrane//integral component of membrane//viral capsid//plasma membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.32972 BF_2 110.00 1.45 3467 270014909 EFA11357.1 2170 5.3e-241 hypothetical protein TcasGA2_TC011514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4Z9 1089 4.9e-117 Protein lines OS=Drosophila melanogaster GN=lin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32973 BF_2 6.00 0.47 825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.32974 BF_2 1160.04 10.25 5020 332373494 AEE61888.1 1056 1.2e-111 unknown [Dendroctonus ponderosae] -- -- -- -- -- K07855 RERG Ras-related and estrogen-regulated growth inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K07855 Q8R367 325 2.8e-28 Ras-related and estrogen-regulated growth inhibitor OS=Mus musculus GN=Rerg PE=2 SV=1 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG0395 Ras-related GTPase Cluster-8309.32975 BF_2 244.34 2.60 4222 642921287 XP_008192801.1 4438 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X1 [Tribolium castaneum] 642921292 XM_008194582.1 488 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X4, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 2.0e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF06371//PF06367//PF01763//PF04561 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Herpesvirus UL6 like//RNA polymerase Rpb2, domain 2 GO:0006351//GO:0006144//GO:0016043//GO:0006206//GO:0006323//GO:0030036 transcription, DNA-templated//purine nucleobase metabolic process//cellular component organization//pyrimidine nucleobase metabolic process//DNA packaging//actin cytoskeleton organization GO:0003899//GO:0003677//GO:0003779//GO:0017048 DNA-directed RNA polymerase activity//DNA binding//actin binding//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.32976 BF_2 51.00 3.18 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.32977 BF_2 20.12 0.33 2874 642911947 XP_008199033.1 1143 5.4e-122 PREDICTED: phospholipid scramblase 2 isoform X1 [Tribolium castaneum] 462310482 APGK01047306.1 73 3.41673e-27 Dendroctonus ponderosae Seq01047316, whole genome shotgun sequence -- -- -- -- O15162 767 8.9e-80 Phospholipid scramblase 1 OS=Homo sapiens GN=PLSCR1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0621 Phospholipid scramblase Cluster-8309.32980 BF_2 70.79 3.79 1069 642935026 XP_008199911.1 274 1.2e-21 PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|642935028|ref|XP_008199912.1| PREDICTED: serine/arginine-rich splicing factor 7-like [Tribolium castaneum]>gi|270012981|gb|EFA09429.1| hypothetical protein TcasGA2_TC010640 [Tribolium castaneum] -- -- -- -- -- K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q3T106 166 1.6e-10 Serine/arginine-rich splicing factor 7 OS=Bos taurus GN=SRSF7 PE=2 SV=1 PF00098 Zinc knuckle -- -- GO:1901363//GO:0043169//GO:0003676//GO:0097159//GO:0008270 heterocyclic compound binding//cation binding//nucleic acid binding//organic cyclic compound binding//zinc ion binding -- -- -- -- Cluster-8309.32984 BF_2 3.92 0.45 652 817088791 XP_012267229.1 139 3.2e-06 PREDICTED: cAMP-dependent protein kinase type I regulatory subunit isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- P16905 132 8.6e-07 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.32985 BF_2 451.65 2.29 8544 642935636 XP_008198092.1 4543 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 6.82218e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.5e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00595//PF00620//PF08718 PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGAP domain//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0051861//GO:0017089//GO:0005515 glycolipid binding//glycolipid transporter activity//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.32986 BF_2 147.18 0.78 8195 642935638 XP_008198093.1 4403 0.0e+00 PREDICTED: rho GTPase-activating protein 21 isoform X2 [Tribolium castaneum] 642935637 XM_008199871.1 245 2.38656e-122 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X2, mRNA -- -- -- -- Q71M21 793 2.4e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00620//PF00595//PF08718 PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF)//Glycolipid transfer protein (GLTP) GO:0046836//GO:0007165 glycolipid transport//signal transduction GO:0005515//GO:0051861//GO:0017089 protein binding//glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.32987 BF_2 211.39 4.55 2230 642913773 XP_008201155.1 1695 4.1e-186 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z401 330 3.2e-29 C-myc promoter-binding protein OS=Homo sapiens GN=DENND4A PE=1 SV=2 PF02055//PF01844//PF02861 O-Glycosyl hydrolase family 30//HNH endonuclease//Clp amino terminal domain, pathogenicity island component GO:0019538//GO:0006687//GO:0005975//GO:0006807//GO:0006665 protein metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process//sphingolipid metabolic process GO:0003676//GO:0004348//GO:0004519 nucleic acid binding//glucosylceramidase activity//endonuclease activity -- -- KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.32991 BF_2 244.08 2.80 3928 546678692 ERL89260.1 3267 0.0e+00 hypothetical protein D910_06633, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 8.2e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.32992 BF_2 1409.67 20.30 3192 642910776 XP_008193405.1 2509 2.4e-280 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 2.23873e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1134 2.7e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.32993 BF_2 468.92 2.85 7164 642910776 XP_008193405.1 2410 1.6e-268 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 5.05401e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1140 1.2e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.32996 BF_2 31.61 0.45 3195 642929093 XP_008195688.1 609 5.0e-60 PREDICTED: uncharacterized protein LOC103313644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00598//PF05372//PF07757 Influenza Matrix protein (M1)//Delta lysin family//Predicted AdoMet-dependent methyltransferase GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005198//GO:0008168//GO:0003723 structural molecule activity//methyltransferase activity//RNA binding GO:0005576 extracellular region -- -- Cluster-8309.32999 BF_2 362.51 3.22 4998 478260665 ENN80362.1 1376 9.0e-149 hypothetical protein YQE_03221, partial [Dendroctonus ponderosae]>gi|478269621|gb|ENN83368.1| hypothetical protein YQE_00276, partial [Dendroctonus ponderosae]>gi|546683697|gb|ERL93475.1| hypothetical protein D910_10766 [Dendroctonus ponderosae] -- -- -- -- -- K08592 SENP1 sentrin-specific protease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08592 Q9VXP4 724 1.5e-74 Platelet-activating factor acetylhydrolase IB subunit beta homolog OS=Drosophila melanogaster GN=Paf-AHalpha PE=1 SV=1 PF02902//PF00657//PF00770 Ulp1 protease family, C-terminal catalytic domain//GDSL-like Lipase/Acylhydrolase//Adenovirus endoprotease GO:0006508 proteolysis GO:0008234//GO:0016788//GO:0004197 cysteine-type peptidase activity//hydrolase activity, acting on ester bonds//cysteine-type endopeptidase activity -- -- KOG0778 Protease, Ulp1 family Cluster-8309.33001 BF_2 7144.46 149.97 2280 546674950 ERL86223.1 2254 6.4e-251 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 8.62217e-112 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1691 5.0e-187 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006108//GO:0055114//GO:0015976//GO:0006099//GO:0006090 malate metabolic process//oxidation-reduction process//carbon utilization//tricarboxylic acid cycle//pyruvate metabolic process GO:0051287//GO:0004471 NAD binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.33005 BF_2 28.69 0.47 2821 91078042 XP_966587.1 612 2.0e-60 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCI3 419 2.0e-39 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33006 BF_2 1472.00 17.86 3734 642928515 XP_008193823.1 150 9.8e-07 PREDICTED: protein C-ets-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.33008 BF_2 209.15 8.15 1361 91088839 XP_970745.1 252 5.3e-19 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01788 PsbJ GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.33011 BF_2 97.53 5.68 1005 189238660 XP_972432.2 1257 1.1e-135 PREDICTED: ribosome biogenesis methyltransferase WBSCR22 [Tribolium castaneum]>gi|270008360|gb|EFA04808.1| hypothetical protein TcasGA2_TC014857 [Tribolium castaneum] -- -- -- -- -- K19306 BUD23 18S rRNA (guanine1575-N7)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19306 Q9CY21 913 3.6e-97 Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Mus musculus GN=Wbscr22 PE=2 SV=1 PF01555//PF08241//PF07757 DNA methylase//Methyltransferase domain//Predicted AdoMet-dependent methyltransferase GO:0008152//GO:0032259//GO:0006306 metabolic process//methylation//DNA methylation GO:0008168//GO:0008170//GO:0003677 methyltransferase activity//N-methyltransferase activity//DNA binding -- -- KOG1541 Predicted protein carboxyl methylase Cluster-8309.33012 BF_2 227.89 2.65 3882 642920301 XP_008192289.1 526 2.6e-50 PREDICTED: interferon regulatory factor 2-binding protein 2 isoform X3 [Tribolium castaneum] 642920300 XM_008194067.1 94 9.81232e-39 PREDICTED: Tribolium castaneum interferon regulatory factor 2-binding protein 2 (LOC664517), transcript variant X3, mRNA -- -- -- -- Q7Z5L9 405 1.1e-37 Interferon regulatory factor 2-binding protein 2 OS=Homo sapiens GN=IRF2BP2 PE=1 SV=2 PF00097//PF02778 Zinc finger, C3HC4 type (RING finger)//tRNA intron endonuclease, N-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213//GO:0046872 tRNA-intron endonuclease activity//metal ion binding GO:0000214 tRNA-intron endonuclease complex KOG3579 Predicted E3 ubiquitin ligase Cluster-8309.33013 BF_2 66.51 0.78 3866 642936487 XP_008198457.1 1993 2.0e-220 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.74337e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1098 4.9e-118 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF05699//PF10613//PF00060//PF01699 hAT family C-terminal dimerisation region//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Sodium/calcium exchanger protein GO:0044699//GO:0006811//GO:0055085//GO:0007165//GO:0006810//GO:0007268 single-organism process//ion transport//transmembrane transport//signal transduction//transport//synaptic transmission GO:0005230//GO:0005234//GO:0004970//GO:0004872//GO:0046983 extracellular ligand-gated ion channel activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//receptor activity//protein dimerization activity GO:0016020//GO:0045202//GO:0071944//GO:0016021 membrane//synapse//cell periphery//integral component of membrane -- -- Cluster-8309.33014 BF_2 27.78 0.45 2846 642932067 XP_008196844.1 2471 5.5e-276 PREDICTED: actin-interacting protein 1 [Tribolium castaneum]>gi|270011670|gb|EFA08118.1| hypothetical protein TcasGA2_TC005722 [Tribolium castaneum] 755951689 XM_011303542.1 201 2.36863e-98 PREDICTED: Fopius arisanus actin-interacting protein 1 (LOC105265810), mRNA -- -- -- -- Q9VU68 2024 1.5e-225 Actin-interacting protein 1 OS=Drosophila melanogaster GN=flr PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0318 WD40 repeat stress protein/actin interacting protein Cluster-8309.33017 BF_2 1269.34 5.87 9328 642938737 XP_008199868.1 1649 3.7e-180 PREDICTED: RNA polymerase II elongation factor ELL [Tribolium castaneum] 642938736 XM_008201646.1 257 5.8008e-129 PREDICTED: Tribolium castaneum RNA polymerase II elongation factor ELL (LOC655479), mRNA K15183 ELL RNA polymerase II elongation factor ELL http://www.genome.jp/dbget-bin/www_bget?ko:K15183 O08856 320 2.0e-27 RNA polymerase II elongation factor ELL OS=Mus musculus GN=Ell PE=2 SV=2 PF10390//PF05732 RNA polymerase II elongation factor ELL//Firmicute plasmid replication protein (RepL) GO:0006260//GO:0006276//GO:0006368 DNA replication//plasmid maintenance//transcription elongation from RNA polymerase II promoter -- -- GO:0008023 transcription elongation factor complex -- -- Cluster-8309.33021 BF_2 885.26 13.59 3012 768419593 XP_011550521.1 1889 1.8e-208 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [Plutella xylostella] 695538883 XM_009544325.1 56 1.01037e-17 Heterobasidion irregulare TC 32-1 hypothetical protein mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 A4FV68 1632 4.6e-180 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Bos taurus GN=PPP2R5E PE=1 SV=1 PF01603 Protein phosphatase 2A regulatory B subunit (B56 family) GO:0007165 signal transduction GO:0008601 protein phosphatase type 2A regulator activity GO:0000159 protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.33022 BF_2 221.55 2.73 3685 642930462 XP_008196413.1 2488 7.6e-278 PREDICTED: phosphofurin acidic cluster sorting protein 1 [Tribolium castaneum]>gi|270009398|gb|EFA05846.1| hypothetical protein TcasGA2_TC008635 [Tribolium castaneum] 558214452 XM_006108296.1 57 3.44448e-18 PREDICTED: Myotis lucifugus phosphofurin acidic cluster sorting protein 2 (PACS2), partial mRNA -- -- -- -- Q9NP66 503 4.6e-49 High mobility group protein 20A OS=Homo sapiens GN=HMG20A PE=1 SV=1 PF07851//PF01166//PF01496 TMPIT-like protein//TSC-22/dip/bun family//V-type ATPase 116kDa subunit family GO:0015991//GO:0006355//GO:0015992 ATP hydrolysis coupled proton transport//regulation of transcription, DNA-templated//proton transport GO:0015078//GO:0003700 hydrogen ion transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667//GO:0033179 integral component of membrane//transcription factor complex//proton-transporting V-type ATPase, V0 domain KOG0381 HMG box-containing protein Cluster-8309.33024 BF_2 53.00 1.61 1666 391344579 XP_003746573.1 477 5.3e-45 PREDICTED: uncharacterized protein LOC100897996 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- Q9W0K4 427 1.4e-40 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF00651//PF10660 BTB/POZ domain//Iron-containing outer mitochondrial membrane protein N-terminus -- -- GO:0005515//GO:0051537 protein binding//2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.33025 BF_2 1936.64 43.75 2139 642910530 XP_008200251.1 1534 1.8e-167 PREDICTED: adenylyl cyclase-associated protein 1 isoform X1 [Tribolium castaneum] 332373619 BT126989.1 136 2.41142e-62 Dendroctonus ponderosae clone DPO019_B13 unknown mRNA K17261 CAP1_2, SRV2 adenylyl cyclase-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17261 P40123 1019 4.0e-109 Adenylyl cyclase-associated protein 2 OS=Homo sapiens GN=CAP2 PE=1 SV=1 PF01213//PF02205//PF08603 Adenylate cyclase associated (CAP) N terminal//WH2 motif//Adenylate cyclase associated (CAP) C terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.33026 BF_2 1041.92 12.84 3681 642936428 XP_008198430.1 1447 3.9e-157 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.22011e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 535 9.0e-53 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.33028 BF_2 1034.95 17.13 2814 270007965 EFA04413.1 1862 2.2e-205 hypothetical protein TcasGA2_TC014713 [Tribolium castaneum] 642924630 XM_008196149.1 178 1.42939e-85 PREDICTED: Tribolium castaneum uncharacterized LOC663690 (LOC663690), transcript variant X3, mRNA K17494 CSRNP cysteine/serine-rich nuclear protein http://www.genome.jp/dbget-bin/www_bget?ko:K17494 Q8WYN3 588 4.9e-59 Cysteine/serine-rich nuclear protein 3 OS=Homo sapiens GN=CSRNP3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33032 BF_2 890.39 38.85 1246 642921313 XP_008192815.1 504 2.9e-48 PREDICTED: proteasome maturation protein [Tribolium castaneum] -- -- -- -- -- K11599 POMP, UMP1 proteasome maturation protein http://www.genome.jp/dbget-bin/www_bget?ko:K11599 Q5R9L9 288 1.3e-24 Proteasome maturation protein OS=Pongo abelii GN=POMP PE=2 SV=1 PF02230//PF00326//PF03583//PF01738 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Secretory lipase//Dienelactone hydrolase family GO:0046486//GO:0006508//GO:0016042 glycerolipid metabolic process//proteolysis//lipid catabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG2112 Lysophospholipase Cluster-8309.33033 BF_2 29.40 0.99 1527 91094775 XP_968026.1 488 2.6e-46 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9I1 145 6.3e-08 Cyclin-G1 OS=Bos taurus GN=CCNG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33037 BF_2 43.59 2.43 1038 149675209 ABR27686.1 1018 6.1e-108 cuticle proprotein proCP5.1 [Callinectes sapidus] 149675208 EF639838.1 359 0 Callinectes sapidus cuticle proprotein proCP5.1 mRNA, complete cds -- -- -- -- P81582 356 1.5e-32 Cuticle protein CP1246 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.33039 BF_2 57.88 0.40 6277 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.23032e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 2.7e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF10417//PF03099//PF01496 C-terminal domain of 1-Cys peroxiredoxin//Biotin/lipoate A/B protein ligase family//V-type ATPase 116kDa subunit family GO:0015992//GO:0055114//GO:0015991//GO:0006464 proton transport//oxidation-reduction process//ATP hydrolysis coupled proton transport//cellular protein modification process GO:0051920//GO:0015078 peroxiredoxin activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.33042 BF_2 73.06 0.64 5060 642932233 XP_008194634.1 902 8.4e-94 PREDICTED: centrosomal protein of 290 kDa-like isoform X1 [Tribolium castaneum]>gi|642932235|ref|XP_008194635.1| PREDICTED: centrosomal protein of 290 kDa-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01445//PF01166 Viral small hydrophobic protein//TSC-22/dip/bun family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0016020 transcription factor complex//membrane -- -- Cluster-8309.33045 BF_2 19.33 0.49 1940 642916102 XP_971729.2 801 1.7e-82 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5E9I8 522 1.5e-51 DDB1- and CUL4-associated factor 11 OS=Bos taurus GN=DCAF11 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.33046 BF_2 229.43 3.06 3425 91078224 XP_969612.1 1164 2.4e-124 PREDICTED: cell division cycle protein 20 homolog [Tribolium castaneum]>gi|270002363|gb|EEZ98810.1| hypothetical protein TcasGA2_TC001383 [Tribolium castaneum] -- -- -- -- -- K03363 CDC20 cell division cycle 20, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03363 Q62623 887 1.3e-93 Cell division cycle protein 20 homolog OS=Rattus norvegicus GN=Cdc20 PE=1 SV=2 PF00498//PF00400 FHA domain//WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.33048 BF_2 913.53 27.94 1655 478249963 ENN70470.1 498 1.9e-47 hypothetical protein YQE_12973, partial [Dendroctonus ponderosae] -- -- -- -- -- K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q9H000 401 1.4e-37 Probable E3 ubiquitin-protein ligase makorin-2 OS=Homo sapiens GN=MKRN2 PE=1 SV=2 PF00097//PF15332//PF17123//PF12678//PF14634//PF08152//PF13639//PF00642//PF12861 Zinc finger, C3HC4 type (RING finger)//Lck-interacting transmembrane adapter 1//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//GUCT (NUC152) domain//Ring finger domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0050853//GO:0016567//GO:0050852 B cell receptor signaling pathway//protein ubiquitination//T cell receptor signaling pathway GO:0008270//GO:0046872//GO:0005524//GO:0004386//GO:0003723//GO:0005515//GO:0004842 zinc ion binding//metal ion binding//ATP binding//helicase activity//RNA binding//protein binding//ubiquitin-protein transferase activity GO:0005634//GO:0005680 nucleus//anaphase-promoting complex -- -- Cluster-8309.33049 BF_2 41.16 1.42 1497 642926721 XP_008194985.1 1279 4.8e-138 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4J913 413 5.1e-39 Facilitated trehalose transporter Tret1 OS=Drosophila grimshawi GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33052 BF_2 187.36 1.82 4582 642910971 XP_008193488.1 686 8.5e-69 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O75410 289 3.8e-24 Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens GN=TACC1 PE=1 SV=2 PF10186//PF12740//PF13851//PF00038//PF08702//PF01509//PF07224 Vacuolar sorting 38 and autophagy-related subunit 14//Chlorophyllase enzyme//Growth-arrest specific micro-tubule binding//Intermediate filament protein//Fibrinogen alpha/beta chain family//TruB family pseudouridylate synthase (N terminal domain)//Chlorophyllase GO:0030168//GO:0010508//GO:0006396//GO:0007165//GO:0015996//GO:0015994//GO:0051258//GO:0048870 platelet activation//positive regulation of autophagy//RNA processing//signal transduction//chlorophyll catabolic process//chlorophyll metabolic process//protein polymerization//cell motility GO:0030674//GO:0005102//GO:0005198//GO:0047746 protein binding, bridging//receptor binding//structural molecule activity//chlorophyllase activity GO:0005577//GO:0031514//GO:0005882 fibrinogen complex//motile cilium//intermediate filament -- -- Cluster-8309.33054 BF_2 30.91 0.37 3794 189241141 XP_973953.2 1608 8.6e-176 PREDICTED: probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [Tribolium castaneum]>gi|270013913|gb|EFA10361.1| hypothetical protein TcasGA2_TC012587 [Tribolium castaneum] 768410303 XM_011559102.1 284 2.29774e-144 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67827 1103 1.3e-118 Casein kinase I isoform alpha OS=Bos taurus GN=CSNK1A1 PE=1 SV=1 PF07850//PF05445//PF00180//PF07714//PF00069 Renin receptor-like protein//Poxvirus serine/threonine protein kinase//Isocitrate/isopropylmalate dehydrogenase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0007165//GO:0055114//GO:0006099 protein phosphorylation//signal transduction//oxidation-reduction process//tricarboxylic acid cycle GO:0016616//GO:0051287//GO:0004872//GO:0005524//GO:0000287//GO:0004449//GO:0004672 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//receptor activity//ATP binding//magnesium ion binding//isocitrate dehydrogenase (NAD+) activity//protein kinase activity GO:0016021 integral component of membrane KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.33055 BF_2 20.00 1.80 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33056 BF_2 31.00 1.27 1310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07716 Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.33057 BF_2 6.29 0.40 949 546677394 ERL88240.1 141 2.7e-06 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03811//PF01007 InsA N-terminal domain//Inward rectifier potassium channel GO:0006813//GO:0006313 potassium ion transport//transposition, DNA-mediated GO:0005242 inward rectifier potassium channel activity GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane -- -- Cluster-8309.33058 BF_2 693.91 24.54 1470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33059 BF_2 919.94 33.53 1435 546677394 ERL88240.1 324 2.5e-27 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- K19363 LITAF lipopolysaccharide-induced tumor necrosis factor-alpha factor http://www.genome.jp/dbget-bin/www_bget?ko:K19363 Q99732 176 1.5e-11 Lipopolysaccharide-induced tumor necrosis factor-alpha factor OS=Homo sapiens GN=LITAF PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33061 BF_2 932.74 15.91 2740 642924917 XP_008194096.1 3260 0.0e+00 PREDICTED: neprilysin-2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08635 MMEL1 membrane metallo-endopeptidase-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08635 O16796 1280 2.8e-139 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.33065 BF_2 741.00 38.61 1090 332376859 AEE63569.1 795 4.6e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K07555 ATPeAF1, ATPAF1, ATP11 ATP synthase mitochondrial F1 complex assembly factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07555 Q1L987 410 8.3e-39 ATP synthase mitochondrial F1 complex assembly factor 1 OS=Danio rerio GN=atpaf1 PE=2 SV=2 PF03717//PF06644 Penicillin-binding Protein dimerisation domain//ATP11 protein GO:0006461 protein complex assembly GO:0008658 penicillin binding GO:0005739 mitochondrion -- -- Cluster-8309.33066 BF_2 1062.62 11.75 4070 478262631 ENN81195.1 1169 7.4e-125 hypothetical protein YQE_02385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 279 4.8e-23 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33067 BF_2 593.86 8.75 3127 642923201 XP_008193653.1 960 9.8e-101 PREDICTED: apoptotic chromatin condensation inducer in the nucleus [Tribolium castaneum]>gi|270007592|gb|EFA04040.1| hypothetical protein TcasGA2_TC014271 [Tribolium castaneum] -- -- -- -- -- K12875 ACIN1, ACINUS apoptotic chromatin condensation inducer in the nucleus http://www.genome.jp/dbget-bin/www_bget?ko:K12875 Q9JIX8 284 9.8e-24 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus GN=Acin1 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2416 Acinus (induces apoptotic chromatin condensation) Cluster-8309.33069 BF_2 5.00 1.12 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33070 BF_2 783.00 8.74 4036 642926470 XP_008191971.1 1644 6.1e-180 PREDICTED: flotillin-2 isoform X1 [Tribolium castaneum] 645037638 XM_008207769.1 344 1.0829e-177 PREDICTED: Nasonia vitripennis flotillin-2 (LOC103316081), mRNA K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61492 1513 3.9e-166 Flotillin-2 OS=Drosophila melanogaster GN=Flo-2 PE=2 SV=3 PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005245 voltage-gated calcium channel activity GO:0005891 voltage-gated calcium channel complex -- -- Cluster-8309.33075 BF_2 25569.00 489.11 2474 642924825 XP_967668.2 889 1.3e-92 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I922 428 1.6e-40 Regucalcin OS=Xenopus laevis GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33076 BF_2 5.00 0.77 558 780637233 XP_011687047.1 166 2.0e-09 PREDICTED: zinc finger protein 90-like [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04988//PF13465//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.33077 BF_2 280.19 2.75 4544 332374512 AEE62397.1 1661 7.4e-182 unknown [Dendroctonus ponderosae]>gi|478256842|gb|ENN77017.1| hypothetical protein YQE_06511, partial [Dendroctonus ponderosae]>gi|546673798|gb|ERL85342.1| hypothetical protein D910_02762 [Dendroctonus ponderosae] 557020770 XM_006010638.1 35 7.22214e-06 PREDICTED: Latimeria chalumnae alcohol dehydrogenase class-3-like (LOC102353852), mRNA K00121 frmA, ADH5, adhC S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00121 P79896 1475 1.1e-161 Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1 PF02826//PF09174//PF03721//PF00107//PF00637//PF08240//PF08097 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Maf1 regulator//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Zinc-binding dehydrogenase//Region in Clathrin and VPS//Alcohol dehydrogenase GroES-like domain//Conotoxin T-superfamily GO:0006886//GO:0016480//GO:0016192//GO:0055114 intracellular protein transport//negative regulation of transcription from RNA polymerase III promoter//vesicle-mediated transport//oxidation-reduction process GO:0051287//GO:0016616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005576 extracellular region KOG0022 Alcohol dehydrogenase, class III Cluster-8309.33078 BF_2 569.00 15.17 1856 91082011 XP_969843.1 1533 2.1e-167 PREDICTED: aladin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NRG9 609 1.2e-61 Aladin OS=Homo sapiens GN=AAAS PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33080 BF_2 184.39 29.34 550 478263054 ENN81454.1 250 3.7e-19 hypothetical protein YQE_02147, partial [Dendroctonus ponderosae]>gi|546686038|gb|ERL95438.1| hypothetical protein D910_12701 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09074//PF01255 Mer2//Putative undecaprenyl diphosphate synthase GO:0007131 reciprocal meiotic recombination GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0000794 condensed nuclear chromosome -- -- Cluster-8309.33081 BF_2 8.61 2.76 417 557771946 XP_005185631.1 158 1.3e-08 PREDICTED: uncharacterized protein LOC101888893 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33083 BF_2 5.60 0.67 637 270011805 EFA08253.1 223 5.7e-16 hypothetical protein TcasGA2_TC005881 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.33085 BF_2 5873.00 194.55 1550 91078136 XP_973521.1 1959 7.0e-217 PREDICTED: heat shock 70 kDa protein cognate 2 [Tribolium castaneum]>gi|270001374|gb|EEZ97821.1| hypothetical protein TcasGA2_TC000188 [Tribolium castaneum] 254578007 XM_002494945.1 143 2.23029e-66 Zygosaccharomyces rouxii hypothetical protein (ZYRO0B00836g) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11146 1746 1.4e-193 Heat shock 70 kDa protein cognate 2 OS=Drosophila melanogaster GN=Hsc70-2 PE=1 SV=2 PF06723//PF02782//PF01968 MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//Hydantoinase/oxoprolinase GO:0005975//GO:0000902 carbohydrate metabolic process//cell morphogenesis GO:0005524//GO:0016773//GO:0016787 ATP binding//phosphotransferase activity, alcohol group as acceptor//hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.33086 BF_2 217.23 1.43 6643 478260037 ENN79822.1 3053 0.0e+00 hypothetical protein YQE_03645, partial [Dendroctonus ponderosae] 642918140 XM_008193162.1 208 7.15013e-102 PREDICTED: Tribolium castaneum ATP-dependent DNA helicase Q4 (LOC655929), mRNA K10730 RECQL4 ATP-dependent DNA helicase Q4 http://www.genome.jp/dbget-bin/www_bget?ko:K10730 Q75NR7 1484 1.5e-162 ATP-dependent DNA helicase Q4 OS=Mus musculus GN=Recql4 PE=2 SV=2 PF00503//PF00485//PF00270//PF03193//PF02367//PF06414//PF00437//PF00098 G-protein alpha subunit//Phosphoribulokinase / Uridine kinase family//DEAD/DEAH box helicase//Protein of unknown function, DUF258//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Type II/IV secretion system protein//Zinc knuckle GO:0002949//GO:0007186//GO:0008152//GO:0007165//GO:0006810 tRNA threonylcarbamoyladenosine modification//G-protein coupled receptor signaling pathway//metabolic process//signal transduction//transport GO:0003676//GO:0016301//GO:0019001//GO:0004871//GO:0005525//GO:0008270//GO:0031683//GO:0005524//GO:0003924 nucleic acid binding//kinase activity//guanyl nucleotide binding//signal transducer activity//GTP binding//zinc ion binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity -- -- KOG0351 ATP-dependent DNA helicase Cluster-8309.33088 BF_2 1381.52 18.73 3373 91078144 XP_973718.1 3646 0.0e+00 PREDICTED: uncharacterized protein LOC662535 [Tribolium castaneum]>gi|270002344|gb|EEZ98791.1| hypothetical protein TcasGA2_TC001355 [Tribolium castaneum] 195498296 XM_002096426.1 190 3.66448e-92 Drosophila yakuba GE25042 (Dyak\GE25042), partial mRNA -- -- -- -- Q8C419 198 9.9e-14 Probable G-protein coupled receptor 158 OS=Mus musculus GN=Gpr158 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.33089 BF_2 187.39 3.51 2521 478251931 ENN72369.1 1766 2.7e-194 hypothetical protein YQE_11004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C419 198 7.4e-14 Probable G-protein coupled receptor 158 OS=Mus musculus GN=Gpr158 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.33090 BF_2 312.61 5.13 2835 478258160 ENN78298.1 1141 9.1e-122 hypothetical protein YQE_05448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZV5 894 1.6e-94 Cysteine and histidine-rich protein 1 homolog OS=Drosophila melanogaster GN=CG32486 PE=2 SV=2 PF02176//PF14634//PF03145 TRAF-type zinc finger//zinc-RING finger domain//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.33091 BF_2 326.99 3.55 4137 270007410 EFA03858.1 1820 2.4e-200 hypothetical protein TcasGA2_TC013974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33092 BF_2 94.91 1.40 3113 134131322 BAF49604.1 893 5.7e-93 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 490 1.3e-47 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004252 hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type endopeptidase activity -- -- KOG2806 Chitinase Cluster-8309.33093 BF_2 59.00 3.62 969 91084011 XP_975320.1 961 2.3e-101 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|270008251|gb|EFA04699.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5M3 303 1.9e-26 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33094 BF_2 306.76 3.76 3704 91084469 XP_970666.1 1691 2.0e-185 PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925528|ref|XP_008194588.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925531|ref|XP_008194589.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum] 817200928 XM_012420774.1 171 1.46936e-81 PREDICTED: Orussus abietinus transcription factor Sp1-like (LOC105697447), transcript variant X5, mRNA -- -- -- -- P18722 282 2.0e-23 Gastrula zinc finger protein XlCGF46.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF05191//PF13465//PF00096 Adenylate kinase, active site lid//Zinc-finger double domain//Zinc finger, C2H2 type GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.33095 BF_2 1450.33 11.60 5519 664763595 XP_008539455.1 327 4.3e-27 PREDICTED: macrophage mannose receptor 1 [Equus przewalskii] -- -- -- -- -- -- -- -- -- P22897 311 1.3e-26 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03161//PF03791 LAGLIDADG DNA endonuclease family//KNOX2 domain -- -- GO:0004519//GO:0003677 endonuclease activity//DNA binding GO:0005634 nucleus -- -- Cluster-8309.33096 BF_2 682.00 53.85 817 674304034 AIL23548.1 633 2.1e-63 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 568 3.0e-57 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.33099 BF_2 28.00 2.31 795 546684965 ERL94539.1 362 5.4e-32 hypothetical protein D910_11816 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q17015 270 1.0e-22 Cuticle protein OS=Anopheles gambiae GN=Ccp84Ab PE=2 SV=3 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.33101 BF_2 29.99 0.35 3837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33102 BF_2 3168.19 186.45 998 332374430 AEE62356.1 617 1.8e-61 unknown [Dendroctonus ponderosae] 347967155 XM_003435977.1 105 1.88906e-45 Anopheles gambiae str. PEST AGAP002085-PC (AgaP_AGAP002085) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33103 BF_2 62.53 0.57 4837 642916719 XP_008192331.1 730 7.1e-74 PREDICTED: coiled-coil domain-containing protein 102A isoform X2 [Tribolium castaneum] -- -- -- -- -- K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q96A19 384 3.8e-35 Coiled-coil domain-containing protein 102A OS=Homo sapiens GN=CCDC102A PE=1 SV=2 PF03938//PF04728//PF07926//PF09728//PF03233//PF11403//PF02601//PF00038//PF07851//PF05478//PF08287//PF04632//PF07058//PF10392//PF13851//PF01920//PF10473//PF00015//PF04136//PF02050//PF04111//PF04048//PF01576//PF06005//PF07989//PF03836//PF04799//PF04513//PF08702//PF16331//PF06009//PF04977//PF06008//PF04508//PF06810//PF00509//PF10174//PF06160//PF11365//PF00769//PF05557//PF04871 Outer membrane protein (OmpH-like)//Lipoprotein leucine-zipper//TPR/MLP1/MLP2-like protein//Myosin-like coiled-coil protein//Aphid transmission protein//Yeast metallothionein//Exonuclease VII, large subunit//Intermediate filament protein//TMPIT-like protein//Prominin//Spc19//Fusaric acid resistance protein family//Microtubule-associated protein 70//Golgi transport complex subunit 5//Growth-arrest specific micro-tubule binding//Prefoldin subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family//Flagellar FliJ protein//Autophagy protein Apg6//Sec8 exocyst complex component specific domain//Myosin tail//Protein of unknown function (DUF904)//Centrosomin N-terminal motif 1//RasGAP C-terminus//fzo-like conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//TolA binding protein trimerisation//Laminin Domain II//Septum formation initiator//Laminin Domain I//Viral A-type inclusion protein repeat//Phage minor structural protein GP20//Haemagglutinin//RIM-binding protein of the cytomatrix active zone//Septation ring formation regulator, EzrA//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Mitotic checkpoint protein//Uso1 / p115 like vesicle tethering protein, C terminal region GO:0010506//GO:0008608//GO:0016032//GO:0006891//GO:0048870//GO:0019089//GO:0030168//GO:0007264//GO:0007165//GO:0006914//GO:0006886//GO:0006810//GO:0007010//GO:0070206//GO:0007049//GO:0015031//GO:0006457//GO:0019064//GO:0007094//GO:0000917//GO:0043093//GO:0006606//GO:0045995//GO:0006935//GO:0071973//GO:0006904//GO:0000921//GO:0008053//GO:0030334//GO:0051258//GO:0071585//GO:0010273//GO:0030155//GO:0007155//GO:0006308 regulation of autophagy//attachment of spindle microtubules to kinetochore//viral process//intra-Golgi vesicle-mediated transport//cell motility//transmission of virus//platelet activation//small GTPase mediated signal transduction//signal transduction//autophagy//intracellular protein transport//transport//cytoskeleton organization//protein trimerization//cell cycle//protein transport//protein folding//fusion of virus membrane with host plasma membrane//mitotic spindle assembly checkpoint//barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of embryonic development//chemotaxis//bacterial-type flagellum-dependent cell motility//vesicle docking involved in exocytosis//septin ring assembly//mitochondrial fusion//regulation of cell migration//protein polymerization//detoxification of cadmium ion//detoxification of copper ion//regulation of cell adhesion//cell adhesion//DNA catabolic process GO:0003924//GO:0045502//GO:0051082//GO:0005102//GO:0046870//GO:0019905//GO:0030674//GO:0003774//GO:0008565//GO:0042803//GO:0008017//GO:0008134//GO:0008092//GO:0005096//GO:0005198//GO:0005507//GO:0008855//GO:0004871//GO:0046789 GTPase activity//dynein binding//unfolded protein binding//receptor binding//cadmium ion binding//syntaxin binding//protein binding, bridging//motor activity//protein transporter activity//protein homodimerization activity//microtubule binding//transcription factor binding//cytoskeletal protein binding//GTPase activator activity//structural molecule activity//copper ion binding//exodeoxyribonuclease VII activity//signal transducer activity//host cell surface receptor binding GO:0019028//GO:0045298//GO:0009288//GO:0005615//GO:0016272//GO:0005667//GO:0031514//GO:0005801//GO:0019867//GO:0005886//GO:0005741//GO:0017119//GO:0016020//GO:0019898//GO:0005882//GO:0009318//GO:0048786//GO:0005577//GO:0030286//GO:0009986//GO:0005815//GO:0016021//GO:0016459//GO:0005940//GO:0042729//GO:0005737//GO:0005876//GO:0019031//GO:0000145 viral capsid//tubulin complex//bacterial-type flagellum//extracellular space//prefoldin complex//transcription factor complex//motile cilium//cis-Golgi network//outer membrane//plasma membrane//mitochondrial outer membrane//Golgi transport complex//membrane//extrinsic component of membrane//intermediate filament//exodeoxyribonuclease VII complex//presynaptic active zone//fibrinogen complex//dynein complex//cell surface//microtubule organizing center//integral component of membrane//myosin complex//septin ring//DASH complex//cytoplasm//spindle microtubule//viral envelope//exocyst -- -- Cluster-8309.33104 BF_2 703.66 26.01 1419 332375458 AEE62870.1 1441 7.4e-157 unknown [Dendroctonus ponderosae]>gi|478250250|gb|ENN70750.1| hypothetical protein YQE_12539, partial [Dendroctonus ponderosae]>gi|546685945|gb|ERL95359.1| hypothetical protein D910_12624 [Dendroctonus ponderosae] -- -- -- -- -- K10424 DCTN2 dynactin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10424 Q1HQF2 837 3.3e-88 Probable dynactin subunit 2 OS=Aedes aegypti GN=Dmn PE=2 SV=2 PF07536//PF01544//PF04513//PF15724//PF08702 HWE histidine kinase//CorA-like Mg2+ transporter protein//Baculovirus polyhedron envelope protein, PEP, C terminus//TMEM119 family//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0001503//GO:0055085//GO:0030168//GO:0016310//GO:0030001 protein polymerization//signal transduction//ossification//transmembrane transport//platelet activation//phosphorylation//metal ion transport GO:0004673//GO:0005102//GO:0005198//GO:0030674//GO:0046873 protein histidine kinase activity//receptor binding//structural molecule activity//protein binding, bridging//metal ion transmembrane transporter activity GO:0005577//GO:0019028//GO:0016020//GO:0019031//GO:0009365 fibrinogen complex//viral capsid//membrane//viral envelope//protein histidine kinase complex KOG3958 Putative dynamitin Cluster-8309.33105 BF_2 81.16 0.60 5953 91088115 XP_969791.1 1930 6.2e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.9e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF04851//PF01105//PF00270 Type III restriction enzyme, res subunit//emp24/gp25L/p24 family/GOLD//DEAD/DEAH box helicase GO:0006810 transport GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0008026 ATP binding//nucleic acid binding//DNA binding//hydrolase activity//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.33106 BF_2 831.53 9.67 3885 646705667 KDR13254.1 541 4.7e-52 hypothetical protein L798_12642, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- B4DXR9 470 3.3e-45 Zinc finger protein 732 OS=Homo sapiens GN=ZNF732 PE=2 SV=1 PF13465//PF16622//PF00122//PF13912//PF07664//PF00096//PF01077//PF07776 Zinc-finger double domain//zinc-finger C2H2-type//E1-E2 ATPase//C2H2-type zinc finger//Ferrous iron transport protein B C terminus//Zinc finger, C2H2 type//Nitrite and sulphite reductase 4Fe-4S domain//Zinc-finger associated domain (zf-AD) GO:0055114//GO:0015684 oxidation-reduction process//ferrous iron transport GO:0015093//GO:0016491//GO:0051536//GO:0000166//GO:0008270//GO:0020037//GO:0046872 ferrous iron transmembrane transporter activity//oxidoreductase activity//iron-sulfur cluster binding//nucleotide binding//zinc ion binding//heme binding//metal ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.33108 BF_2 628.44 18.86 1681 91085165 XP_970735.1 1565 3.7e-171 PREDICTED: septin-1 [Tribolium castaneum]>gi|270008471|gb|EFA04919.1| hypothetical protein TcasGA2_TC014984 [Tribolium castaneum] 213514885 NM_001140440.1 121 4.11255e-54 Salmo salar septin 2 (sept2), mRNA >gnl|BL_ORD_ID|5992956 Salmo salar clone ssal-rgf-535-071 Septin-2 putative mRNA, complete cds K16942 SEPT2 septin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16942 P42207 1406 4.1e-154 Septin-1 OS=Drosophila melanogaster GN=Sep1 PE=1 SV=1 PF03193//PF00005//PF04548//PF00071//PF04670//PF00735//PF08477//PF01926//PF05049 Protein of unknown function, DUF258//ABC transporter//AIG1 family//Ras family//Gtr1/RagA G protein conserved region//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Interferon-inducible GTPase (IIGP) GO:0007049//GO:0007264 cell cycle//small GTPase mediated signal transduction GO:0005524//GO:0003924//GO:0005525//GO:0016887 ATP binding//GTPase activity//GTP binding//ATPase activity GO:0031105//GO:0016020 septin complex//membrane -- -- Cluster-8309.33110 BF_2 741.00 25.62 1497 189238926 XP_001811313.1 931 1.1e-97 PREDICTED: acyl-CoA-binding domain-containing protein 5A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641E3 357 1.6e-32 Acyl-CoA-binding domain-containing protein 5 OS=Xenopus laevis GN=acbd5 PE=2 SV=1 PF00887//PF09177//PF04728 Acyl CoA binding protein//Syntaxin 6, N-terminal//Lipoprotein leucine-zipper GO:0048193 Golgi vesicle transport GO:0000062 fatty-acyl-CoA binding GO:0019867//GO:0016020 outer membrane//membrane KOG0817 Acyl-CoA-binding protein Cluster-8309.33111 BF_2 961.66 15.30 2917 91086235 XP_966692.1 3186 0.0e+00 PREDICTED: transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum]>gi|270011017|gb|EFA07465.1| transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum] 817081112 XM_012407627.1 596 0 PREDICTED: Athalia rosae transitional endoplasmic reticulum ATPase TER94 (LOC105690094), transcript variant X2, mRNA K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7KN62 2968 0.0e+00 Transitional endoplasmic reticulum ATPase TER94 OS=Drosophila melanogaster GN=TER94 PE=1 SV=1 PF07728//PF01695//PF00158//PF01057//PF00004//PF02367//PF06414//PF02562//PF00931//PF14532//PF06068//PF01443//PF05496//PF00437//PF07724//PF07726//PF03266//PF00005//PF04851//PF01637//PF02456//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein//NB-ARC domain//Sigma-54 interaction domain//TIP49 C-terminus//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//NTPase//ABC transporter//Type III restriction enzyme, res subunit//Archaeal ATPase//Adenovirus IVa2 protein//RNA helicase GO:0006310//GO:0002949//GO:0006355//GO:0006281//GO:0006810//GO:0019079//GO:0019083 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair//transport//viral genome replication//viral transcription GO:0003724//GO:0017111//GO:0009378//GO:0043531//GO:0003723//GO:0003678//GO:0003677//GO:0016887//GO:0016301//GO:0008134//GO:0005524//GO:0016787//GO:0098519 RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//ADP binding//RNA binding//DNA helicase activity//DNA binding//ATPase activity//kinase activity//transcription factor binding//ATP binding//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0730 AAA+-type ATPase Cluster-8309.33112 BF_2 242.35 1.60 6604 189237519 XP_973030.2 3420 0.0e+00 PREDICTED: uncharacterized protein LOC661798 [Tribolium castaneum]>gi|270007705|gb|EFA04153.1| hypothetical protein TcasGA2_TC014398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6N043 283 2.7e-23 Zinc finger protein 280D OS=Homo sapiens GN=ZNF280D PE=1 SV=3 PF05485//PF03470//PF01667//PF13465//PF09367 THAP domain//XS zinc finger domain//Ribosomal protein S27//Zinc-finger double domain//CpeS-like protein GO:0017009//GO:0042254//GO:0031047//GO:0006412 protein-phycocyanobilin linkage//ribosome biogenesis//gene silencing by RNA//translation GO:0046872//GO:0003735//GO:0003676 metal ion binding//structural constituent of ribosome//nucleic acid binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.33113 BF_2 53.85 0.43 5519 478262467 ENN81138.1 1903 7.7e-210 hypothetical protein YQE_02505, partial [Dendroctonus ponderosae] -- -- -- -- -- K14258 TRET1 facilitated trehalose transporter http://www.genome.jp/dbget-bin/www_bget?ko:K14258 Q17NV8 1407 1.0e-153 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33116 BF_2 10.76 0.48 1228 642937482 XP_008198857.1 257 1.3e-19 PREDICTED: protein tramtrack, beta isoform-like isoform X18 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33117 BF_2 230.00 3.12 3374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33118 BF_2 172.13 2.84 2819 189238157 XP_976123.2 1599 7.0e-175 PREDICTED: adiponectin receptor protein isoform X2 [Tribolium castaneum] 332372817 BT126587.1 395 0 Dendroctonus ponderosae clone DPO1421_D03 unknown mRNA K07297 ADIPOR adiponectin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K07297 Q9VCY8 1306 2.7e-142 Adiponectin receptor protein OS=Drosophila melanogaster GN=AdipoR PE=1 SV=2 PF03006//PF00060 Haemolysin-III related//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0748 Predicted membrane proteins, contain hemolysin III domain Cluster-8309.33120 BF_2 2137.66 31.61 3116 270000732 EEZ97179.1 2876 0.0e+00 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] 642937909 XM_008202132.1 344 8.33833e-178 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 1179 1.6e-127 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 PF06220//PF00096 U1 zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.33122 BF_2 1022.91 27.72 1831 642937320 XP_008198786.1 1339 6.5e-145 PREDICTED: venom carboxylesterase-6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 942 2.9e-100 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.33124 BF_2 688.67 8.01 3885 642917882 XP_008191369.1 1010 1.9e-106 PREDICTED: uncharacterized protein LOC103312469 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64322 300 1.7e-25 Neural proliferation differentiation and control protein 1 OS=Mus musculus GN=Npdc1 PE=2 SV=2 PF06809 Neural proliferation differentiation control-1 protein (NPDC1) -- -- -- -- GO:0016021 integral component of membrane KOG3884 Neural proliferation, differentiation and control protein Cluster-8309.33126 BF_2 131.00 2.88 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03094 Mlo family GO:0006952 defense response -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33128 BF_2 262.70 6.52 1973 642934812 XP_008197820.1 552 1.3e-53 PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934814|ref|XP_008197821.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934816|ref|XP_008197822.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934818|ref|XP_008197823.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum] -- -- -- -- -- K17555 PPP1R14B protein phosphatase 1 regulatory subunit 14B http://www.genome.jp/dbget-bin/www_bget?ko:K17555 -- -- -- -- PF05361 PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation -- -- GO:0005737 cytoplasm -- -- Cluster-8309.33132 BF_2 59.99 0.48 5463 642927835 XP_972081.2 781 9.7e-80 PREDICTED: LOW QUALITY PROTEIN: probable glucosamine 6-phosphate N-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00621 GNPNAT1, GNA1 glucosamine-phosphate N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00621 Q9VAI0 611 2.1e-61 Probable glucosamine 6-phosphate N-acetyltransferase OS=Drosophila melanogaster GN=CG1969 PE=2 SV=1 PF00583//PF13508//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3396 Glucosamine-phosphate N-acetyltransferase Cluster-8309.33134 BF_2 930.00 21.05 2135 91087123 XP_975206.1 1775 2.1e-195 PREDICTED: mRNA export factor [Tribolium castaneum]>gi|270011088|gb|EFA07536.1| RAE1 RNA export 1 homolog [Tribolium castaneum] 807019675 XM_004520208.2 175 5.02882e-84 PREDICTED: Ceratitis capitata mRNA export factor (LOC101455898), mRNA K14298 RAE1, GLE2 mRNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14298 Q7ZWF0 1424 4.3e-156 mRNA export factor OS=Danio rerio GN=rae1 PE=2 SV=2 PF08122//PF00400 NADH-ubiquinone oxidoreductase B12 subunit family//WD domain, G-beta repeat GO:0022900 electron transport chain GO:0005515 protein binding GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG0647 mRNA export protein (contains WD40 repeats) Cluster-8309.33135 BF_2 278.40 3.28 3834 402535161 AFQ62107.1 809 3.9e-83 female-specific doublesex isoform f2 [Tribolium castaneum] 642928399 XR_511419.1 167 2.5459e-79 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 7.3e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF00751//PF01104 DM DNA binding domain//Bunyavirus non-structural protein NS-s GO:0006355//GO:0016032 regulation of transcription, DNA-templated//viral process GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.33136 BF_2 1908.92 13.90 6030 642929745 XP_008195958.1 2579 3.5e-288 PREDICTED: uncharacterized protein LOC664426 isoform X1 [Tribolium castaneum]>gi|270010581|gb|EFA07029.1| hypothetical protein TcasGA2_TC010001 [Tribolium castaneum] 242020070 XM_002430435.1 44 9.53512e-11 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF00008//PF06112//PF03067//PF09172//PF05887//PF05433 EGF-like domain//Gammaherpesvirus capsid protein//Chitin binding domain//Domain of unknown function (DUF1943)//Procyclic acidic repetitive protein (PARP)//Glycine zipper 2TM domain GO:0006869 lipid transport GO:0005515//GO:0005319 protein binding//lipid transporter activity GO:0019867//GO:0016020//GO:0019028 outer membrane//membrane//viral capsid -- -- Cluster-8309.33141 BF_2 115.00 6.31 1050 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33142 BF_2 383.72 7.36 2468 91085407 XP_967344.1 1098 7.7e-117 PREDICTED: peroxisome assembly protein 12 [Tribolium castaneum] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.8e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF07685//PF13639//PF12678//PF00097 CobB/CobQ-like glutamine amidotransferase domain//Ring finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0046872//GO:0003824//GO:0008270 protein binding//metal ion binding//catalytic activity//zinc ion binding -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.33143 BF_2 271.64 2.50 4828 478263554 ENN81890.1 1552 3.4e-169 hypothetical protein YQE_01728, partial [Dendroctonus ponderosae] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9XZ43 1076 2.2e-115 Protein 5NUC OS=Lutzomyia longipalpis GN=5NUC PE=1 SV=1 PF02872//PF00149//PF03615 5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase//GCM motif protein GO:0009166//GO:0006355 nucleotide catabolic process//regulation of transcription, DNA-templated GO:0016787//GO:0003677 hydrolase activity//DNA binding -- -- -- -- Cluster-8309.33144 BF_2 3341.26 42.20 3599 642933582 XP_008197481.1 1654 3.8e-181 PREDICTED: protein 5NUC-like [Tribolium castaneum]>gi|270011322|gb|EFA07770.1| hypothetical protein TcasGA2_TC005324 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9XZ43 1159 3.9e-125 Protein 5NUC OS=Lutzomyia longipalpis GN=5NUC PE=1 SV=1 PF03615//PF00149//PF02872 GCM motif protein//Calcineurin-like phosphoesterase//5'-nucleotidase, C-terminal domain GO:0006355//GO:0009166 regulation of transcription, DNA-templated//nucleotide catabolic process GO:0005488//GO:0003677//GO:0016787 binding//DNA binding//hydrolase activity -- -- -- -- Cluster-8309.33146 BF_2 24.00 10.47 381 546677957 ERL88690.1 200 1.6e-13 hypothetical protein D910_06073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33147 BF_2 203.00 11.76 1009 170321839 BAG14264.1 383 2.5e-34 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P16295 155 2.9e-09 Coagulation factor IX (Fragment) OS=Cavia porcellus GN=F9 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33148 BF_2 3.00 1.81 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33149 BF_2 34.38 0.76 2181 642912278 XP_967486.2 462 3.8e-43 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BJR6 139 4.4e-07 Serine protease 27 OS=Mus musculus GN=Prss27 PE=2 SV=1 PF00757//PF00089//PF00296 Furin-like cysteine rich region//Trypsin//Luciferase-like monooxygenase GO:0006468//GO:0007169//GO:0055114//GO:0006508 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway//oxidation-reduction process//proteolysis GO:0016705//GO:0005524//GO:0004714//GO:0004252 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ATP binding//transmembrane receptor protein tyrosine kinase activity//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.3315 BF_2 3.00 0.57 507 874446720 XP_012955380.1 646 4.1e-65 PREDICTED: LOW QUALITY PROTEIN: 60S ribosomal protein L23a [Anas platyrhynchos] 694967839 XM_511361.4 507 0 PREDICTED: Pan troglodytes ribosomal protein L23a (RPL23A), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62750 646 1.7e-66 60S ribosomal protein L23a OS=Homo sapiens GN=RPL23A PE=1 SV=1 PF00276//PF00347 Ribosomal protein L23//Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.33150 BF_2 298.66 5.68 2485 642919219 XP_969254.2 711 5.8e-72 PREDICTED: peroxiredoxin-5, mitochondrial [Tribolium castaneum] -- -- -- -- -- K11187 PRDX5 peroxiredoxin 5, atypical 2-Cys peroxiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K11187 Q9GLW9 460 3.0e-44 Peroxiredoxin-5, mitochondrial OS=Papio hamadryas GN=PRDX5 PE=2 SV=1 PF00578//PF16367//PF08534//PF01848//PF00076 AhpC/TSA family//RNA recognition motif//Redoxin//Hok/gef family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0055114 oxidation-reduction process GO:0016209//GO:0003676//GO:0016491 antioxidant activity//nucleic acid binding//oxidoreductase activity GO:0016020 membrane KOG0541 Alkyl hydroperoxide reductase/peroxiredoxin Cluster-8309.33152 BF_2 179.32 2.33 3513 478251301 ENN71769.1 1449 2.2e-157 hypothetical protein YQE_11504, partial [Dendroctonus ponderosae] -- -- -- -- -- K01487 E3.5.4.3, guaD guanine deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01487 Q9WTT6 937 2.1e-99 Guanine deaminase OS=Rattus norvegicus GN=Gda PE=1 SV=1 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3968 Atrazine chlorohydrolase/guanine deaminase Cluster-8309.33154 BF_2 754.85 17.00 2145 642939420 XP_008200384.1 2172 1.9e-241 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha isoform X1 [Tribolium castaneum]>gi|270016503|gb|EFA12949.1| hypothetical protein TcasGA2_TC005069 [Tribolium castaneum] 801401384 XM_012205696.1 102 1.92312e-43 PREDICTED: Atta cephalotes phosphatidylinositol 4-kinase type 2-alpha (LOC105624338), mRNA K13711 PI4K2 phosphatidylinositol 4-kinase type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13711 Q6DCQ8 1416 3.7e-155 Phosphatidylinositol 4-kinase type 2-beta OS=Xenopus laevis GN=pi4k2b PE=2 SV=1 PF07945//PF14987//PF00454//PF17050 Janus-atracotoxin//NADH dehydrogenase 1 alpha subcomplex subunit 3//Phosphatidylinositol 3- and 4-kinase//Altered inheritance of mitochondria 5 GO:0042407//GO:0009405 cristae formation//pathogenesis GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0005576//GO:0005747//GO:0061617//GO:0005743//GO:0044284 extracellular region//mitochondrial respiratory chain complex I//MICOS complex//mitochondrial inner membrane//mitochondrial crista junction KOG2381 Phosphatidylinositol 4-kinase Cluster-8309.33155 BF_2 1856.23 33.76 2587 283046740 NP_001164317.1 1036 1.2e-109 TAK1-associated binding protein 2 isoform B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K90 180 9.3e-12 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Mus musculus GN=Tab2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.33157 BF_2 635.00 9.73 3017 270014262 EFA10710.1 289 6.0e-23 domino [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33158 BF_2 934.00 77.86 789 546674022 ERL85515.1 346 3.9e-30 hypothetical protein D910_02934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15330 126 5.2e-06 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF02909 Tetracyclin repressor, C-terminal all-alpha domain GO:0045892 negative regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.33159 BF_2 2474.00 702.22 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33162 BF_2 1070.46 10.46 4570 91088509 XP_971592.1 4199 0.0e+00 PREDICTED: pre-mRNA-processing factor 6 [Tribolium castaneum]>gi|270011722|gb|EFA08170.1| hypothetical protein TcasGA2_TC005794 [Tribolium castaneum] 542217355 XM_003439025.2 118 5.26887e-52 PREDICTED: Oreochromis niloticus pre-mRNA-processing factor 6-like (LOC100696507), mRNA K12855 PRPF6, PRP6 pre-mRNA-processing factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12855 O94906 3341 0.0e+00 Pre-mRNA-processing factor 6 OS=Homo sapiens GN=PRPF6 PE=1 SV=1 PF13414//PF01267//PF01115//PF13371//PF00515//PF02259//PF05843//PF02099//PF13181//PF06424 TPR repeat//F-actin capping protein alpha subunit//F-actin capping protein, beta subunit//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Suppressor of forked protein (Suf)//Josephin//Tetratricopeptide repeat//PRP1 splicing factor, N-terminal GO:0000398//GO:0051016//GO:0006397 mRNA splicing, via spliceosome//barbed-end actin filament capping//mRNA processing GO:0005515//GO:0008242 protein binding//omega peptidase activity GO:0008290//GO:0005634 F-actin capping protein complex//nucleus KOG0495 HAT repeat protein Cluster-8309.33164 BF_2 951.62 20.25 2253 642919440 XP_008191870.1 2286 1.2e-254 PREDICTED: striatin-3 [Tribolium castaneum] 768432640 XM_011559352.1 116 3.33525e-51 PREDICTED: Plutella xylostella striatin-3 (LOC105388449), mRNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q13033 782 1.3e-81 Striatin-3 OS=Homo sapiens GN=STRN3 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0642 Cell-cycle nuclear protein, contains WD-40 repeats Cluster-8309.33165 BF_2 133.06 3.05 2113 546678779 ERL89331.1 640 8.4e-64 hypothetical protein D910_06703 [Dendroctonus ponderosae] 291201233 FP340408.1 101 6.81186e-43 33G08_SfBAC_fin, Spodoptera frugiperda BAC, egg DNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q9ERG2 549 1.2e-54 Striatin-3 OS=Mus musculus GN=Strn3 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0295 WD40 repeat-containing protein Cluster-8309.33166 BF_2 279.39 6.45 2098 546678779 ERL89331.1 640 8.4e-64 hypothetical protein D910_06703 [Dendroctonus ponderosae] 291201233 FP340408.1 101 6.76269e-43 33G08_SfBAC_fin, Spodoptera frugiperda BAC, egg DNA K17608 STRN1_3_4 striatin 1/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17608 Q9ERG2 549 1.2e-54 Striatin-3 OS=Mus musculus GN=Strn3 PE=1 SV=1 PF00400//PF14304 WD domain, G-beta repeat//Transcription termination and cleavage factor C-terminal GO:0031124 mRNA 3'-end processing GO:0005515 protein binding -- -- KOG0295 WD40 repeat-containing protein Cluster-8309.33169 BF_2 630.08 13.76 2203 478251878 ENN72317.1 1686 4.5e-185 hypothetical protein YQE_11060, partial [Dendroctonus ponderosae] -- -- -- -- -- K02216 CHK1 serine/threonine-protein kinase Chk1 http://www.genome.jp/dbget-bin/www_bget?ko:K02216 O61661 1014 1.5e-108 Serine/threonine-protein kinase grp OS=Drosophila melanogaster GN=grp PE=1 SV=2 PF00069//PF07714//PF00924 Protein kinase domain//Protein tyrosine kinase//Mechanosensitive ion channel GO:0055085//GO:0006468 transmembrane transport//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0016020 membrane KOG0590 Checkpoint kinase and related serine/threonine protein kinases Cluster-8309.33171 BF_2 89.08 4.01 1217 91083379 XP_967173.1 375 2.6e-33 PREDICTED: heat shock factor-binding protein 1 [Tribolium castaneum]>gi|270007782|gb|EFA04230.1| hypothetical protein TcasGA2_TC014481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDI2 225 2.6e-17 Heat shock factor-binding protein 1 OS=Pongo abelii GN=HSBP1 PE=3 SV=1 PF02865//PF04513//PF00103//PF06152//PF05478//PF06008 STAT protein, protein interaction domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Somatotropin hormone family//Phage minor capsid protein 2//Prominin//Laminin Domain I GO:0007165//GO:0030334//GO:0045995//GO:0006355//GO:0030155 signal transduction//regulation of cell migration//regulation of embryonic development//regulation of transcription, DNA-templated//regulation of cell adhesion GO:0005179//GO:0005198//GO:0003700//GO:0004871//GO:0005102 hormone activity//structural molecule activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity//receptor binding GO:0005667//GO:0019031//GO:0019028//GO:0016021//GO:0005576 transcription factor complex//viral envelope//viral capsid//integral component of membrane//extracellular region KOG4117 Heat shock factor binding protein Cluster-8309.33172 BF_2 100.00 1.87 2528 91087217 XP_975478.1 949 1.5e-99 PREDICTED: paired box pox-meso protein [Tribolium castaneum] 9967368 AB039660.1 138 2.2088e-63 Lethenteron camtschaticum Pax-9 mRNA for paired box protein, complete cds K09382 PAX1_9 paired box protein 1/9 http://www.genome.jp/dbget-bin/www_bget?ko:K09382 P23757 650 2.9e-66 Paired box pox-meso protein OS=Drosophila melanogaster GN=Poxm PE=2 SV=3 PF02751//PF00292 Transcription initiation factor IIA, gamma subunit//'Paired box' domain GO:0006355//GO:0006367 regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex KOG3517 Transcription factor PAX1/9 Cluster-8309.33174 BF_2 1847.84 17.09 4811 478254660 ENN74901.1 1230 7.4e-132 hypothetical protein YQE_08479, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12109 CXCR4 Chemokine receptor N terminal -- -- GO:0019955 cytokine binding -- -- -- -- Cluster-8309.33175 BF_2 40.38 1.07 1867 478259677 ENN79521.1 367 3.4e-32 hypothetical protein YQE_03984, partial [Dendroctonus ponderosae]>gi|546682947|gb|ERL92826.1| hypothetical protein D910_10134 [Dendroctonus ponderosae] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 O17040 224 5.3e-17 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 OS=Caenorhabditis elegans GN=hpo-8 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.33179 BF_2 115.44 5.87 1110 642931814 XP_008196744.1 1242 6.9e-134 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 894 6.4e-95 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF06584//PF00067 DIRP//Cytochrome P450 GO:0006351//GO:0007049//GO:0055114 transcription, DNA-templated//cell cycle//oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding GO:0017053 transcriptional repressor complex -- -- Cluster-8309.33180 BF_2 1029.21 38.83 1396 642930414 XP_008196390.1 760 6.8e-78 PREDICTED: BAG family molecular chaperone regulator 2 [Tribolium castaneum]>gi|270009406|gb|EFA05854.1| hypothetical protein TcasGA2_TC008649 [Tribolium castaneum] -- -- -- -- -- K09556 BAG2 BCL2-associated athanogene 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09556 Q91YN9 304 2.1e-26 BAG family molecular chaperone regulator 2 OS=Mus musculus GN=Bag2 PE=1 SV=1 PF06005 Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737 cytoplasm KOG3633 BAG family molecular chaperone regulator 2 Cluster-8309.33181 BF_2 71.60 2.65 1417 642930414 XP_008196390.1 488 2.4e-46 PREDICTED: BAG family molecular chaperone regulator 2 [Tribolium castaneum]>gi|270009406|gb|EFA05854.1| hypothetical protein TcasGA2_TC008649 [Tribolium castaneum] -- -- -- -- -- K09556 BAG2 BCL2-associated athanogene 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09556 Q91YN9 217 2.6e-16 BAG family molecular chaperone regulator 2 OS=Mus musculus GN=Bag2 PE=1 SV=1 PF01544 CorA-like Mg2+ transporter protein GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG3633 BAG family molecular chaperone regulator 2 Cluster-8309.33182 BF_2 549.24 2.47 9602 91091742 XP_966408.1 1295 4.3e-139 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 953 8.0e-101 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF03431//PF02424//PF05372//PF00202 RNA replicase, beta-chain//ApbE family//Delta lysin family//Aminotransferase class-III GO:0006144//GO:0019079//GO:0008152//GO:0017013//GO:0019836 purine nucleobase metabolic process//viral genome replication//metabolic process//protein flavinylation//hemolysis by symbiont of host erythrocytes GO:0030170//GO:0008483//GO:0003968 pyridoxal phosphate binding//transaminase activity//RNA-directed RNA polymerase activity GO:0031379//GO:0005576 RNA-directed RNA polymerase complex//extracellular region KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.33183 BF_2 78.79 0.47 7311 642911280 XP_008199354.1 1164 5.1e-124 PREDICTED: glutamate-gated chloride channel isoform X4 [Tribolium castaneum] 462373324 APGK01024787.1 67 1.89503e-23 Dendroctonus ponderosae Seq01024797, whole genome shotgun sequence K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1000 2.2e-106 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.33185 BF_2 8.00 0.54 910 -- -- -- -- -- 817197946 XM_012419174.1 34 5.05075e-06 PREDICTED: Orussus abietinus eukaryotic initiation factor 4A-I (LOC105696595), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33186 BF_2 421.79 8.10 2465 91094219 XP_973249.1 584 3.1e-57 PREDICTED: uncharacterized protein C9orf85 homolog isoform X2 [Tribolium castaneum]>gi|270016216|gb|EFA12662.1| hypothetical protein TcasGA2_TC002245 [Tribolium castaneum] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q5TZ51 297 2.4e-25 Protein Mpv17 OS=Danio rerio GN=mpv17 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.33187 BF_2 2682.00 12.00 9636 642913145 XP_008201411.1 14553 0.0e+00 PREDICTED: uncharacterized protein LOC663838 isoform X1 [Tribolium castaneum] 642913144 XM_008203189.1 1767 0 PREDICTED: Tribolium castaneum uncharacterized LOC663838 (LOC663838), transcript variant X1, mRNA -- -- -- -- P10079 1340 1.1e-145 Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.33188 BF_2 101.00 9.17 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33189 BF_2 214.00 7.96 1412 642913147 XP_008201412.1 1842 2.3e-203 PREDICTED: uncharacterized protein LOC663838 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB4 254 1.3e-20 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF03146//PF00057 Agrin NtA domain//Low-density lipoprotein receptor domain class A GO:0043113//GO:0007213 receptor clustering//G-protein coupled acetylcholine receptor signaling pathway GO:0043236//GO:0005515 laminin binding//protein binding -- -- -- -- Cluster-8309.33191 BF_2 147.00 3.11 2263 642919122 XP_972010.2 1641 7.6e-180 PREDICTED: uncharacterized protein LOC660708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXT5 1126 1.6e-121 CWF19-like protein 2 homolog OS=Drosophila melanogaster GN=CG9213 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2477 Uncharacterized conserved protein Cluster-8309.33193 BF_2 2257.14 16.14 6137 91088413 XP_966659.1 6133 0.0e+00 PREDICTED: TATA-binding protein-associated factor 172 [Tribolium castaneum]>gi|270011757|gb|EFA08205.1| hypothetical protein TcasGA2_TC005832 [Tribolium castaneum] 347966666 XM_321235.5 345 4.59232e-178 Anopheles gambiae str. PEST AGAP001820-PA (AgaP_AGAP001820) mRNA, complete cds K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 3145 0.0e+00 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF00176//PF02985//PF02262//PF15247 SNF2 family N-terminal domain//HEAT repeat//CBL proto-oncogene N-terminal domain 1//Histone RNA hairpin-binding protein RNA-binding domain GO:0007166//GO:0007165 cell surface receptor signaling pathway//signal transduction GO:0004871//GO:0005515//GO:0003677//GO:0005524//GO:0003723//GO:0004386 signal transducer activity//protein binding//DNA binding//ATP binding//RNA binding//helicase activity GO:0005634 nucleus KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.33194 BF_2 266.84 1.43 8079 91085649 XP_970922.1 6731 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R422 759 2.1e-78 CD109 antigen OS=Mus musculus GN=Cd109 PE=2 SV=1 PF07678//PF13639//PF01835//PF00432//PF02033//PF07677//PF00057//PF00207 A-macroglobulin complement component//Ring finger domain//MG2 domain//Prenyltransferase and squalene oxidase repeat//Ribosome-binding factor A//A-macroglobulin receptor//Low-density lipoprotein receptor domain class A//Alpha-2-macroglobulin family GO:0006364//GO:0010951 rRNA processing//negative regulation of endopeptidase activity GO:0008270//GO:0004866//GO:0005515//GO:0003824 zinc ion binding//endopeptidase inhibitor activity//protein binding//catalytic activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.33195 BF_2 350.53 2.33 6571 91088413 XP_966659.1 4714 0.0e+00 PREDICTED: TATA-binding protein-associated factor 172 [Tribolium castaneum]>gi|270011757|gb|EFA08205.1| hypothetical protein TcasGA2_TC005832 [Tribolium castaneum] 831521961 XM_012862362.1 239 4.13761e-119 PREDICTED: Fundulus heteroclitus BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (btaf1), mRNA K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 2080 1.1e-231 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF00176//PF02985//PF07571//PF02262 SNF2 family N-terminal domain//HEAT repeat//TAF6 C-terminal HEAT repeat domain//CBL proto-oncogene N-terminal domain 1 GO:0007166//GO:0051090//GO:0007165 cell surface receptor signaling pathway//regulation of sequence-specific DNA binding transcription factor activity//signal transduction GO:0004871//GO:0005515//GO:0003677//GO:0005524//GO:0004386 signal transducer activity//protein binding//DNA binding//ATP binding//helicase activity GO:0005634 nucleus KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.33197 BF_2 508.89 4.10 5484 642933562 XP_008197472.1 1789 1.3e-196 PREDICTED: serine-enriched protein isoform X5 [Tribolium castaneum] 642933561 XM_008199250.1 510 0 PREDICTED: Tribolium castaneum serine-enriched protein (LOC100142243), transcript variant X5, mRNA -- -- -- -- O61366 1469 6.7e-161 Serine-enriched protein OS=Drosophila melanogaster GN=gprs PE=3 SV=3 PF02214//PF00651 BTB/POZ domain//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- -- -- Cluster-8309.33199 BF_2 494.61 14.20 1744 646716704 KDR19844.1 661 2.6e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.1e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33201 BF_2 65.75 0.32 8842 642917305 XP_008199244.1 6926 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X5 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3643 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF02710//PF02784//PF00501 DMAP1-binding Domain//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//Pyridoxal-dependent decarboxylase, pyridoxal binding domain//AMP-binding enzyme GO:0019064//GO:0007165//GO:0008152 fusion of virus membrane with host plasma membrane//signal transduction//metabolic process GO:0008134//GO:0003824//GO:0016788//GO:0046789 transcription factor binding//catalytic activity//hydrolase activity, acting on ester bonds//host cell surface receptor binding GO:0005667//GO:0019031//GO:0005634//GO:0009986 transcription factor complex//viral envelope//nucleus//cell surface KOG3628 Predicted AMP-binding protein Cluster-8309.33202 BF_2 2078.85 23.42 4001 642911681 XP_008200699.1 3110 0.0e+00 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1160 3.3e-125 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF03121//PF00620//PF07647//PF01852 Herpesviridae UL52/UL70 DNA primase//RhoGAP domain//SAM domain (Sterile alpha motif)//START domain GO:0006351//GO:0007165//GO:0006269//GO:0006260 transcription, DNA-templated//signal transduction//DNA replication, synthesis of RNA primer//DNA replication GO:0008289//GO:0003896//GO:0005515 lipid binding//DNA primase activity//protein binding GO:0005657//GO:0005730 replication fork//nucleolus KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.33203 BF_2 662.00 17.08 1909 642912793 XP_972568.2 1791 2.6e-197 PREDICTED: uncharacterized protein LOC661310 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 B3A0N5 1334 1.1e-145 Apyrase OS=Tabanus yao PE=1 SV=1 PF00149//PF02872 Calcineurin-like phosphoesterase//5'-nucleotidase, C-terminal domain GO:0009166 nucleotide catabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.33208 BF_2 887.87 33.62 1392 91079436 XP_968348.1 1081 4.0e-115 PREDICTED: solute carrier family 25 member 35 [Tribolium castaneum]>gi|270004397|gb|EFA00845.1| hypothetical protein TcasGA2_TC003733 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 A3KPP4 787 2.1e-82 Solute carrier family 25 member 35 OS=Danio rerio GN=slc25a35 PE=2 SV=1 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.33212 BF_2 769.94 6.86 4983 349584990 BAL03255.1 1077 4.2e-114 93 kDa serpin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JJ64 477 6.5e-46 Uncharacterized serpin-like protein TK1782 OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=TK1782 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33216 BF_2 2672.92 72.38 1832 91084843 XP_966905.1 1225 1.1e-131 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 840 1.9e-88 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01073//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0003854//GO:0050662//GO:0003824//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.33218 BF_2 1940.13 15.64 5477 642926494 XP_008191978.1 1005 1.0e-105 PREDICTED: ribosomal RNA processing protein 1 homolog [Tribolium castaneum] -- -- -- -- -- K14849 RRP1 ribosomal RNA-processing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14849 Q9VJZ7 595 1.5e-59 Ribosomal RNA processing protein 1 homolog OS=Drosophila melanogaster GN=Nnp-1 PE=1 SV=1 PF02865//PF04614//PF05997//PF01347//PF00435 STAT protein, protein interaction domain//Pex19 protein family//Nucleolar protein,Nop52//Lipoprotein amino terminal region//Spectrin repeat GO:0006364//GO:0006355//GO:0007165//GO:0006869 rRNA processing//regulation of transcription, DNA-templated//signal transduction//lipid transport GO:0004871//GO:0003700//GO:0005515//GO:0005319 signal transducer activity//transcription factor activity, sequence-specific DNA binding//protein binding//lipid transporter activity GO:0030688//GO:0005667//GO:0005777 preribosome, small subunit precursor//transcription factor complex//peroxisome KOG3911 Nucleolar protein NOP52/RRP1 Cluster-8309.33219 BF_2 153.67 1.51 4552 642939310 XP_008200401.1 1203 9.4e-129 PREDICTED: tRNA (guanine(37)-N1)-methyltransferase [Tribolium castaneum] -- -- -- -- -- K15429 TRM5, TRMT5 tRNA (guanine37-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15429 Q8IRE4 942 7.1e-100 tRNA (guanine(37)-N1)-methyltransferase OS=Drosophila melanogaster GN=CG32281 PE=2 SV=2 PF08241//PF08245//PF14750//PF09445//PF02875//PF02086 Methyltransferase domain//Mur ligase middle domain//Integrator complex subunit 2//RNA cap guanine-N2 methyltransferase//Mur ligase family, glutamate ligase domain//D12 class N6 adenine-specific DNA methyltransferase GO:0006306//GO:0009058//GO:0001510//GO:0032775//GO:0009452//GO:0008152 DNA methylation//biosynthetic process//RNA methylation//DNA methylation on adenine//7-methylguanosine RNA capping//metabolic process GO:0008168//GO:0009007//GO:0005524//GO:0016874 methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//ATP binding//ligase activity GO:0032039 integrator complex KOG2525 Folylpolyglutamate synthase Cluster-8309.33220 BF_2 901.00 6.69 5922 91079969 XP_969838.1 970 1.3e-101 PREDICTED: beta-1,3-galactosyltransferase 5 [Tribolium castaneum]>gi|270004605|gb|EFA01053.1| hypothetical protein TcasGA2_TC003969 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N293 329 1.1e-28 Beta-1,3-galactosyltransferase 5 (Fragment) OS=Gorilla gorilla gorilla GN=B3GALT5 PE=3 SV=2 PF00119//PF13762//PF01762 ATP synthase A chain//Mitochondrial splicing apparatus component//Galactosyltransferase GO:0000372//GO:0006486//GO:0015986//GO:0015992 Group I intron splicing//protein glycosylation//ATP synthesis coupled proton transport//proton transport GO:0016740//GO:0015078//GO:0008378 transferase activity//hydrogen ion transmembrane transporter activity//galactosyltransferase activity GO:0030529//GO:0016020 intracellular ribonucleoprotein complex//membrane -- -- Cluster-8309.33221 BF_2 555.94 31.65 1022 546676446 ERL87451.1 215 7.8e-15 hypothetical protein D910_04843 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33222 BF_2 420.63 4.97 3828 642937984 XP_008199157.1 261 1.4e-19 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 178 2.3e-11 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 PF00957//PF07535//PF08294 Synaptobrevin//DBF zinc finger//TIM21 GO:0030150//GO:0016192 protein import into mitochondrial matrix//vesicle-mediated transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005744//GO:0016021 mitochondrial inner membrane presequence translocase complex//integral component of membrane KOG1362 Choline transporter-like protein Cluster-8309.33223 BF_2 887.34 21.77 1992 642937984 XP_008199157.1 347 7.5e-30 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 161 1.1e-09 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33225 BF_2 62.46 0.78 3643 347966510 XP_321327.5 366 8.6e-32 AGAP001756-PA [Anopheles gambiae str. PEST]>gi|333470028|gb|EAA01239.5| AGAP001756-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- A5PK40 287 5.1e-24 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.33228 BF_2 558.40 10.55 2501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33229 BF_2 106.00 2.35 2178 270001300 EEZ97747.1 413 1.8e-37 nimrod A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 214 8.9e-16 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF07546 EMI domain -- -- GO:0005515 protein binding -- -- KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.33230 BF_2 2795.00 37.60 3397 91086973 XP_973336.1 1777 1.9e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 1048 2.7e-112 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF05199//PF02254//PF00732//PF07992//PF05834 GMC oxidoreductase//TrkA-N domain//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein GO:0006813//GO:0055114//GO:0016117 potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016705//GO:0016614 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.33231 BF_2 26.23 0.63 2042 572316441 XP_006623846.1 472 2.5e-44 PREDICTED: serine proteinase stubble-like isoform X1 [Apis dorsata]>gi|572316443|ref|XP_006623847.1| PREDICTED: serine proteinase stubble-like isoform X2 [Apis dorsata] -- -- -- -- -- -- -- -- -- Q2KJ63 275 7.1e-23 Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33232 BF_2 10.00 1.53 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33233 BF_2 366.19 2.41 6638 91090320 XP_972446.1 2561 4.7e-286 PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|642934930|ref|XP_008197867.1| PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|270013809|gb|EFA10257.1| hypothetical protein TcasGA2_TC012457 [Tribolium castaneum] 642934931 XR_511636.1 696 0 PREDICTED: Tribolium castaneum rho-related BTB domain-containing protein 2 (LOC661174), transcript variant X2, misc_RNA K07868 RHOBTB1_2 Rho-related BTB domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07868 Q9DAK3 906 1.6e-95 Rho-related BTB domain-containing protein 1 OS=Mus musculus GN=Rhobtb1 PE=1 SV=2 PF08477//PF00651//PF00071 Ras of Complex, Roc, domain of DAPkinase//BTB/POZ domain//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005515//GO:0005525 protein binding//GTP binding GO:0005622 intracellular -- -- Cluster-8309.33235 BF_2 61.00 2.97 1145 7271959 AAF44709.1 458 5.8e-43 acyl-CoA delta-9 desaturase [Argyrotaenia velutinana] -- -- -- -- -- K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q6US81 381 2.0e-35 Acyl-CoA Delta(11) desaturase OS=Spodoptera littoralis PE=1 SV=1 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-8309.3324 BF_2 3.00 0.83 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33240 BF_2 446.64 11.10 1970 572316441 XP_006623846.1 481 2.1e-45 PREDICTED: serine proteinase stubble-like isoform X1 [Apis dorsata]>gi|572316443|ref|XP_006623847.1| PREDICTED: serine proteinase stubble-like isoform X2 [Apis dorsata] -- -- -- -- -- -- -- -- -- Q2KJ63 275 6.8e-23 Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33241 BF_2 401.10 5.05 3607 546679553 ERL90001.1 1213 5.2e-130 hypothetical protein D910_07360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08283 Geminivirus rep protein central domain GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.33244 BF_2 58.86 0.37 6966 642916405 XP_008191009.1 2357 2.2e-262 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.8e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF03114//PF09360//PF00018//PF14604 IRSp53/MIM homology domain//BAR domain//Iron-binding zinc finger CDGSH type//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515//GO:0051537 protein binding//2 iron, 2 sulfur cluster binding GO:0005737//GO:0043231 cytoplasm//intracellular membrane-bounded organelle -- -- Cluster-8309.33246 BF_2 364.60 1.73 9111 642911061 XP_008200558.1 3908 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 575 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2828 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520//PF00813//PF00057 Ion transport protein//FliP family//Low-density lipoprotein receptor domain class A GO:0055085//GO:0009306//GO:0006811 transmembrane transport//protein secretion//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.33247 BF_2 5.54 0.55 706 642935430 XP_008198007.1 515 8.7e-50 PREDICTED: LOW QUALITY PROTEIN: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 388 1.9e-36 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33248 BF_2 1219.98 33.85 1795 91090210 XP_967762.1 1509 1.2e-164 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9XT55 625 1.6e-63 UDP-glucuronosyltransferase 2B19 OS=Macaca fascicularis GN=UGT2B19 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016740//GO:0016758 transferase activity//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.33251 BF_2 286.10 1.41 8789 817054227 XP_012266426.1 1648 4.6e-180 PREDICTED: phosphoribosyl pyrophosphate synthase-associated protein 2 isoform X1 [Athalia rosae] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA -- -- -- -- Q5ZL26 1288 1.0e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF14572//PF00156 Phosphoribosyl synthetase-associated domain//Phosphoribosyl transferase domain GO:0006098//GO:0009116//GO:0006144//GO:0009165 pentose-phosphate shunt//nucleoside metabolic process//purine nucleobase metabolic process//nucleotide biosynthetic process GO:0004749//GO:0000287 ribose phosphate diphosphokinase activity//magnesium ion binding -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.33253 BF_2 816.21 13.04 2906 642913255 XP_008201459.1 819 2.0e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 6.87057e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.3e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.33254 BF_2 3.00 0.48 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33258 BF_2 11.00 5.10 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33259 BF_2 164.63 1.27 5703 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.22246e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 Q16204 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Homo sapiens GN=CCDC6 PE=1 SV=2 PF04434//PF04551//PF04647 SWIM zinc finger//GcpE protein//Accessory gene regulator B GO:0055114//GO:0009372//GO:0009405//GO:0016114 oxidation-reduction process//quorum sensing//pathogenesis//terpenoid biosynthetic process GO:0008270//GO:0008233//GO:0046429 zinc ion binding//peptidase activity//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.33260 BF_2 190.55 2.48 3507 642933032 XP_008197237.1 2247 6.4e-250 PREDICTED: serine/threonine-protein kinase unc-51 isoform X2 [Tribolium castaneum] 820865549 XM_003698790.2 61 1.95802e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 913 1.3e-96 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF00069//PF06293//PF07714//PF12063 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Domain of unknown function (DUF3543) GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.33261 BF_2 594.94 33.78 1024 91090900 XP_973581.1 767 7.7e-79 PREDICTED: peroxisomal membrane protein PMP22 [Tribolium castaneum]>gi|270013225|gb|EFA09673.1| hypothetical protein TcasGA2_TC011801 [Tribolium castaneum] -- -- -- -- -- K13347 PXMP2, PMP22 peroxisomal membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13347 Q9ZS51 231 4.5e-18 Peroxisomal membrane protein PMP22 OS=Arabidopsis thaliana GN=PMP22 PE=1 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.33263 BF_2 57.04 2.99 1086 270012506 EFA08954.1 1063 3.9e-113 hypothetical protein TcasGA2_TC006661 [Tribolium castaneum] 768434472 XM_011560346.1 38 3.62476e-08 PREDICTED: Plutella xylostella atrial natriuretic peptide receptor 1 (LOC105389255), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P16066 622 2.2e-63 Atrial natriuretic peptide receptor 1 OS=Homo sapiens GN=NPR1 PE=1 SV=1 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.33264 BF_2 3080.22 59.66 2447 642932067 XP_008196844.1 2877 0.0e+00 PREDICTED: actin-interacting protein 1 [Tribolium castaneum]>gi|270011670|gb|EFA08118.1| hypothetical protein TcasGA2_TC005722 [Tribolium castaneum] 755951689 XM_011303542.1 201 2.03378e-98 PREDICTED: Fopius arisanus actin-interacting protein 1 (LOC105265810), mRNA -- -- -- -- Q9VU68 2356 4.2e-264 Actin-interacting protein 1 OS=Drosophila melanogaster GN=flr PE=2 SV=1 PF04053//PF03178//PF00400 Coatomer WD associated region//CPSF A subunit region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198//GO:0003676 protein binding//structural molecule activity//nucleic acid binding GO:0030117//GO:0005634 membrane coat//nucleus KOG0318 WD40 repeat stress protein/actin interacting protein Cluster-8309.33265 BF_2 290.97 5.20 2630 91089737 XP_975124.1 1653 3.6e-181 PREDICTED: protein RFT1 homolog [Tribolium castaneum]>gi|270011306|gb|EFA07754.1| hypothetical protein TcasGA2_TC005308 [Tribolium castaneum] -- -- -- -- -- K06316 RFT1 oligosaccharide translocation protein RFT1 http://www.genome.jp/dbget-bin/www_bget?ko:K06316 Q9Y123 1075 1.6e-115 Protein RFT1 homolog OS=Drosophila melanogaster GN=CG3149 PE=2 SV=1 PF01384//PF04506 Phosphate transporter family//Rft protein GO:0006817//GO:0006869 phosphate ion transport//lipid transport GO:0005319//GO:0005315 lipid transporter activity//inorganic phosphate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.33266 BF_2 1394.00 21.37 3016 644993549 XP_008213019.1 157 1.2e-07 PREDICTED: probable phospholipid-transporting ATPase IA isoform X3 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33268 BF_2 69.26 0.63 4888 642931172 XP_008196469.1 2267 4.3e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33269 BF_2 749.92 5.65 5842 642931172 XP_008196469.1 2267 5.1e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33270 BF_2 460.27 6.79 3123 478250396 ENN70891.1 1074 5.9e-114 hypothetical protein YQE_12296, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8AWW5 248 1.5e-19 Cysteine-rich motor neuron 1 protein OS=Gallus gallus GN=CRIM1 PE=2 SV=1 PF02822//PF00093 Antistasin family//von Willebrand factor type C domain -- -- GO:0004867//GO:0005515 serine-type endopeptidase inhibitor activity//protein binding -- -- KOG1216 von Willebrand factor and related coagulation proteins Cluster-8309.33272 BF_2 359.02 3.11 5112 642921170 XP_008192744.1 2383 1.6e-265 PREDICTED: ATP-binding cassette sub-family B member 10, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K05657 ABCB10 ATP-binding cassette, subfamily B (MDR/TAP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05657 Q9NRK6 1543 1.6e-169 ATP-binding cassette sub-family B member 10, mitochondrial OS=Homo sapiens GN=ABCB10 PE=1 SV=2 PF14991//PF07728//PF13304//PF00664//PF03193//PF10288//PF00005//PF06414 Protein melan-A//AAA domain (dynein-related subfamily)//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//Cytoplasmic tRNA 2-thiolation protein 2//ABC transporter//Zeta toxin GO:0006810//GO:0002098//GO:0055085//GO:0034227 transport//tRNA wobble uridine modification//transmembrane transport//tRNA thio-modification GO:0042626//GO:0016301//GO:0016887//GO:0005525//GO:0000049//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//GTP binding//tRNA binding//GTPase activity//ATP binding GO:0042470//GO:0016021 melanosome//integral component of membrane KOG0058 Peptide exporter, ABC superfamily Cluster-8309.33274 BF_2 334.74 2.42 6079 642914773 XP_008190345.1 1450 2.9e-157 PREDICTED: protein SERAC1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SNQ7 389 1.3e-35 Protein SERAC1 OS=Danio rerio GN=serac1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33275 BF_2 9325.52 84.85 4885 24646906 NP_731941.1 804 1.9e-82 effete, isoform A [Drosophila melanogaster]>gi|187117170|ref|NP_001119686.1| effete [Acyrthosiphon pisum]>gi|442619106|ref|NP_001262578.1| effete, isoform B [Drosophila melanogaster]>gi|442619108|ref|NP_001262579.1| effete, isoform C [Drosophila melanogaster]>gi|58381090|ref|XP_310998.2| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|91077526|ref|XP_970430.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|156550189|ref|XP_001605481.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Nasonia vitripennis]>gi|157134117|ref|XP_001663154.1| AAEL003103-PA [Aedes aegypti]>gi|194743322|ref|XP_001954149.1| GF18131 [Drosophila ananassae]>gi|194900836|ref|XP_001979961.1| GG21088 [Drosophila erecta]>gi|195061220|ref|XP_001995948.1| GH14086 [Drosophila grimshawi]>gi|195113175|ref|XP_002001144.1| GI10619 [Drosophila mojavensis]>gi|195143851|ref|XP_002012910.1| GL23670 [Drosophila persimilis]>gi|195328929|ref|XP_002031164.1| GM25828 [Drosophila sechellia]>gi|195390905|ref|XP_002054107.1| GJ22971 [Drosophila virilis]>gi|195444200|ref|XP_002069759.1| GK11688 [Drosophila willistoni]>gi|195501528|ref|XP_002097834.1| eff [Drosophila yakuba]>gi|195570846|ref|XP_002103415.1| GD20402 [Drosophila simulans]>gi|198451027|ref|XP_002137205.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|498939690|ref|XP_004521259.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|498939696|ref|XP_004521261.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|557775059|ref|XP_005187176.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Musca domestica]>gi|746860060|ref|XP_011060857.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Acromyrmex echinatior]>gi|749733753|ref|XP_011147642.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Harpegnathos saltator]>gi|751469127|ref|XP_011189731.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera cucurbitae]>gi|751776279|ref|XP_011214825.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|751776281|ref|XP_011214826.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|755991226|ref|XP_011312803.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Fopius arisanus]>gi|759038025|ref|XP_011351525.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Cerapachys biroi]>gi|766937511|ref|XP_011501212.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratosolen solmsi marchali]>gi|769846059|ref|XP_011634316.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Pogonomyrmex barbatus]>gi|780635308|ref|XP_011686505.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Wasmannia auropunctata]>gi|795091706|ref|XP_011879556.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Vollenhovia emeryi]>gi|801395562|ref|XP_012058392.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Atta cephalotes]>gi|815791114|ref|XP_012216125.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Linepithema humile]>gi|817074138|ref|XP_012259245.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Athalia rosae]>gi|817201924|ref|XP_012276729.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Orussus abietinus]>gi|826426802|ref|XP_012527496.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Monomorium pharaonis]>gi|136643|sp|P25867.1|UBCD1_DROME RecName: Full=Ubiquitin-conjugating enzyme E2-17 kDa; AltName: Full=Protein effete; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-protein ligase>gi|8783|emb|CAA44453.1| ubiquitin-conjugating enzyme [Drosophila melanogaster]>gi|7299919|gb|AAF55093.1| effete, isoform A [Drosophila melanogaster]>gi|16648156|gb|AAL25343.1| GH14739p [Drosophila melanogaster]>gi|46561756|gb|AAT01083.1| putative ubiquitin-conjugating enzyme [Homalodisca vitripennis]>gi|55243675|gb|EAA06420.3| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|89473748|gb|ABD72686.1| putative ubiquitin-conjugating enzyme [Acyrthosiphon pisum]>gi|94468952|gb|ABF18325.1| ubiquitin-conjugating enzyme [Aedes aegypti]>gi|108881406|gb|EAT45631.1| AAEL003103-PA [Aedes aegypti]>gi|190627186|gb|EDV42710.1| GF18131 [Drosophila ananassae]>gi|190651664|gb|EDV48919.1| GG21088 [Drosophila erecta]>gi|193891740|gb|EDV90606.1| GH14086 [Drosophila grimshawi]>gi|193917738|gb|EDW16605.1| GI10619 [Drosophila mojavensis]>gi|194101853|gb|EDW23896.1| GL23670 [Drosophila persimilis]>gi|194120107|gb|EDW42150.1| GM25828 [Drosophila sechellia]>gi|194152193|gb|EDW67627.1| GJ22971 [Drosophila virilis]>gi|194165844|gb|EDW80745.1| GK11688 [Drosophila willistoni]>gi|194183935|gb|EDW97546.1| eff [Drosophila yakuba]>gi|194199342|gb|EDX12918.1| GD20402 [Drosophila simulans]>gi|198131302|gb|EDY67763.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|220945198|gb|ACL85142.1| eff-PA, partial [synthetic construct]>gi|220955014|gb|ACL90050.1| eff-PA [synthetic construct]>gi|239791033|dbj|BAH72034.1| ACYPI000078 [Acyrthosiphon pisum]>gi|270002752|gb|EEZ99199.1| effete [Tribolium castaneum]>gi|332375666|gb|AEE62974.1| unknown [Dendroctonus ponderosae]>gi|440217433|gb|AGB95959.1| effete, isoform B [Drosophila melanogaster]>gi|440217434|gb|AGB95960.1| effete, isoform C [Drosophila melanogaster]>gi|478262539|gb|ENN81177.1| hypothetical protein YQE_02422, partial [Dendroctonus ponderosae]>gi|546683237|gb|ERL93069.1| hypothetical protein D910_10371 [Dendroctonus ponderosae]>gi|646714335|gb|KDR18345.1| Ubiquitin-conjugating enzyme E2-17 kDa [Zootermopsis nevadensis]>gi|861642908|gb|KMQ94120.1| ubiquitin-conjugating enzyme [Lasius niger]>gi|900914055|gb|KMZ03557.1| uncharacterized protein Dsimw501_GD20402 [Drosophila simulans] 642914089 XM_965337.3 556 0 PREDICTED: Tribolium castaneum effete (LOC658996), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P25867 804 7.7e-84 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=eff PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0015031//GO:0007067//GO:0007140//GO:0030718//GO:0045676//GO:0048132//GO:0006464//GO:0016322//GO:0031647//GO:0007286//GO:0008054//GO:0016567//GO:0051276 protein transport//mitotic nuclear division//male meiosis//germ-line stem cell population maintenance//regulation of R7 cell differentiation//female germ-line stem cell asymmetric division//cellular protein modification process//neuron remodeling//regulation of protein stability//spermatid development//negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation//protein ubiquitination//chromosome organization GO:0005524//GO:0004842//GO:0005515 ATP binding//ubiquitin-protein transferase activity//protein binding GO:0005875 microtubule associated complex KOG0417 Ubiquitin-protein ligase Cluster-8309.33276 BF_2 12.77 0.67 1082 189239183 XP_966847.2 761 4.0e-78 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q7KT91 626 7.4e-64 Non-lysosomal glucosylceramidase OS=Drosophila melanogaster GN=CG33090 PE=1 SV=1 PF01204//PF04685 Trehalase//Protein of unknown function, DUF608 GO:0005991//GO:0006665//GO:0005985//GO:0005982//GO:0005975//GO:0006687//GO:0006680//GO:0006807 trehalose metabolic process//sphingolipid metabolic process//sucrose metabolic process//starch metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//glucosylceramide catabolic process//nitrogen compound metabolic process GO:0004555//GO:0004348 alpha,alpha-trehalase activity//glucosylceramidase activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.33277 BF_2 81.38 1.57 2457 123227460 CAM27169.1 250 1.6e-18 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] -- -- -- -- -- K09194 SP4 transcription factor Sp4 http://www.genome.jp/dbget-bin/www_bget?ko:K09194 Q8TC21 239 1.3e-18 Zinc finger protein 596 OS=Homo sapiens GN=ZNF596 PE=2 SV=2 PF13465//PF00096//PF00993//PF01644//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Class II histocompatibility antigen, alpha domain//Chitin synthase//C2H2-type zinc finger GO:0006031//GO:0019882//GO:0006955 chitin biosynthetic process//antigen processing and presentation//immune response GO:0046872//GO:0004100 metal ion binding//chitin synthase activity GO:0042613//GO:0016020 MHC class II protein complex//membrane -- -- Cluster-8309.33278 BF_2 1994.14 46.27 2090 91089709 XP_974931.1 354 1.2e-30 PREDICTED: eukaryotic translation initiation factor 4E-binding protein 2 [Tribolium castaneum]>gi|270012640|gb|EFA09088.1| hypothetical protein TcasGA2_TC006808 [Tribolium castaneum] -- -- -- -- -- K18644 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18644 P56649 235 3.1e-18 Glyceraldehyde-3-phosphate dehydrogenase OS=Panulirus versicolor PE=1 SV=1 PF05456//PF02800//PF02768//PF09771//PF00044 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//DNA polymerase III beta subunit, C-terminal domain//Transmembrane protein 188//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0035307//GO:0045947//GO:0006260//GO:0055114 positive regulation of protein dephosphorylation//negative regulation of translational initiation//DNA replication//oxidation-reduction process GO:0003677//GO:0003887//GO:0008408//GO:0016620//GO:0008190 DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//eukaryotic initiation factor 4E binding GO:0009360//GO:0042575//GO:0071595 DNA polymerase III complex//DNA polymerase complex//Nem1-Spo7 phosphatase complex KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.33279 BF_2 292.98 6.18 2269 91079828 XP_970042.1 661 3.3e-66 PREDICTED: aprataxin [Tribolium castaneum]>gi|642918234|ref|XP_008191423.1| PREDICTED: aprataxin [Tribolium castaneum]>gi|270004538|gb|EFA00986.1| hypothetical protein TcasGA2_TC003899 [Tribolium castaneum] -- -- -- -- -- K10863 APTX aprataxin http://www.genome.jp/dbget-bin/www_bget?ko:K10863 P61799 437 1.3e-41 Aprataxin OS=Danio rerio GN=aptx PE=2 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG0562 Predicted hydrolase (HIT family) Cluster-8309.3328 BF_2 2.00 0.46 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33280 BF_2 1442.00 31.14 2224 91083597 XP_968968.1 941 1.1e-98 PREDICTED: Golgi reassembly-stacking protein 2 [Tribolium castaneum]>gi|270007834|gb|EFA04282.1| hypothetical protein TcasGA2_TC014572 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99JX3 799 1.3e-83 Golgi reassembly-stacking protein 2 OS=Mus musculus GN=Gorasp2 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3834 Golgi reassembly stacking protein GRASP65, contains PDZ domain Cluster-8309.33281 BF_2 755.48 5.44 6100 546675274 ERL86510.1 3807 0.0e+00 hypothetical protein D910_03914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR5 714 2.6e-73 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 PF02881//PF00616 SRP54-type protein, helical bundle domain//GTPase-activator protein for Ras-like GTPase GO:0043087//GO:0006614 regulation of GTPase activity//SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.33282 BF_2 40.04 0.45 4035 642913258 XP_008201460.1 819 2.8e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 175 9.57331e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 1.0e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.33283 BF_2 2399.87 39.28 2843 642913255 XP_008201459.1 819 2.0e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 6.71975e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.2e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF01024//PF16367//PF00076 Colicin pore forming domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding GO:0016021 integral component of membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.33286 BF_2 73.30 1.24 2767 478260541 ENN80244.1 467 1.3e-43 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 5.46305e-30 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q12974 310 8.4e-27 Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens GN=PTP4A2 PE=1 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.33287 BF_2 299.10 5.23 2680 91095137 XP_972151.1 803 1.3e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.26046e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.7e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.33288 BF_2 1479.00 24.20 2844 91081701 XP_970909.1 655 2.1e-65 PREDICTED: uncharacterized protein LOC659516 [Tribolium castaneum]>gi|642921305|ref|XP_008192810.1| PREDICTED: uncharacterized protein LOC659516 [Tribolium castaneum]>gi|642921307|ref|XP_008192811.1| PREDICTED: uncharacterized protein LOC659516 [Tribolium castaneum]>gi|270006461|gb|EFA02909.1| PDGF- and VEGF-related factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- C0K3N1 137 9.9e-07 Snake venom vascular endothelial growth factor toxin barietin OS=Bitis arietans PE=1 SV=1 PF00341 PDGF/VEGF domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.33292 BF_2 2360.51 18.69 5571 642922760 XP_008193313.1 2754 1.6e-308 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X2 [Tribolium castaneum] 751220523 XM_011165095.1 223 2.749e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 1040 3.8e-111 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF00849//PF00951//PF13895 RNA pseudouridylate synthase//Arterivirus GL envelope glycoprotein//Immunoglobulin domain GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982//GO:0005515 RNA binding//pseudouridine synthase activity//protein binding GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.33293 BF_2 6551.46 60.02 4853 642913622 XP_008201092.1 2545 2.5e-284 PREDICTED: moesin/ezrin/radixin homolog 1 isoform X3 [Tribolium castaneum] 347964053 XM_003436981.1 595 0 Anopheles gambiae str. PEST AGAP000562-PB (MOEH_ANOGA) mRNA, complete cds K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 2316 3.6e-259 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF06456//PF03114//PF14604//PF00018//PF00769//PF02255//PF00887//PF05531 Arfaptin-like domain//BAR domain//Variant SH3 domain//SH3 domain//Ezrin/radixin/moesin family//PTS system, Lactose/Cellobiose specific IIA subunit//Acyl CoA binding protein//Nucleopolyhedrovirus P10 protein GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0000062//GO:0019904//GO:0008092//GO:0005515 fatty-acyl-CoA binding//protein domain specific binding//cytoskeletal protein binding//protein binding GO:0005737//GO:0019898//GO:0019028 cytoplasm//extrinsic component of membrane//viral capsid KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.33294 BF_2 56.11 0.45 5523 642913622 XP_008201092.1 2545 2.8e-284 PREDICTED: moesin/ezrin/radixin homolog 1 isoform X3 [Tribolium castaneum] 347964053 XM_003436981.1 592 0 Anopheles gambiae str. PEST AGAP000562-PB (MOEH_ANOGA) mRNA, complete cds K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 2316 4.1e-259 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF05531//PF00887//PF03114//PF06456//PF14604//PF00018//PF02255//PF00769 Nucleopolyhedrovirus P10 protein//Acyl CoA binding protein//BAR domain//Arfaptin-like domain//Variant SH3 domain//SH3 domain//PTS system, Lactose/Cellobiose specific IIA subunit//Ezrin/radixin/moesin family GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0019904//GO:0008092//GO:0000062 protein binding//protein domain specific binding//cytoskeletal protein binding//fatty-acyl-CoA binding GO:0005737//GO:0019028//GO:0019898 cytoplasm//viral capsid//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.33295 BF_2 372.01 5.02 3389 546682082 ERL92068.1 2477 1.3e-276 hypothetical protein D910_09390 [Dendroctonus ponderosae] -- -- -- -- -- K12487 GIT2 G protein-coupled receptor kinase interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12487 Q14161 1018 8.2e-109 ARF GTPase-activating protein GIT2 OS=Homo sapiens GN=GIT2 PE=1 SV=2 PF06005//PF01412//PF13851//PF10392//PF06156//PF13606//PF03836//PF00023//PF01166 Protein of unknown function (DUF904)//Putative GTPase activating protein for Arf//Growth-arrest specific micro-tubule binding//Golgi transport complex subunit 5//Protein of unknown function (DUF972)//Ankyrin repeat//RasGAP C-terminus//Ankyrin repeat//TSC-22/dip/bun family GO:0048870//GO:0006891//GO:0007264//GO:0043093//GO:0000917//GO:0006355//GO:0006260 cell motility//intra-Golgi vesicle-mediated transport//small GTPase mediated signal transduction//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription, DNA-templated//DNA replication GO:0005515//GO:0005096//GO:0003700 protein binding//GTPase activator activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0031514//GO:0005737//GO:0017119 transcription factor complex//motile cilium//cytoplasm//Golgi transport complex KOG0818 GTPase-activating proteins of the GIT family Cluster-8309.33297 BF_2 2235.12 25.64 3934 91078996 XP_974675.1 1185 1.0e-126 PREDICTED: zinc transporter ZIP1 [Tribolium castaneum]>gi|270003679|gb|EFA00127.1| hypothetical protein TcasGA2_TC002943 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 P59889 292 1.5e-24 Zinc transporter ZIP1 OS=Danio rerio GN=slc39a1 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0044765//GO:0055085 metal ion transport//single-organism transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.33298 BF_2 262.29 1.76 6512 642924598 XP_008194358.1 2023 1.1e-223 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] 827557233 XM_012694434.1 87 1.28571e-34 PREDICTED: Bombyx mori Rho-associated protein kinase (rock1), transcript variant X1, mRNA K17388 ROCK2 Rho-associated protein kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17388 M3TYT0 1033 2.9e-110 Rho-associated protein kinase 2 OS=Sus scrofa GN=ROCK2 PE=1 SV=1 PF08912//PF00130//PF01420//PF00769//PF04513 Rho Binding//Phorbol esters/diacylglycerol binding domain (C1 domain)//Type I restriction modification DNA specificity domain//Ezrin/radixin/moesin family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006304//GO:0035556 DNA modification//intracellular signal transduction GO:0017048//GO:0005198//GO:0003677//GO:0008092 Rho GTPase binding//structural molecule activity//DNA binding//cytoskeletal protein binding GO:0005737//GO:0019031//GO:0019898//GO:0019028 cytoplasm//viral envelope//extrinsic component of membrane//viral capsid KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.33299 BF_2 399.00 3.62 4901 642921392 XP_008192848.1 1098 1.5e-116 PREDICTED: cell adhesion molecule 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03490//PF13895 Variant-surface-glycoprotein phospholipase C//Immunoglobulin domain GO:0006650 glycerophospholipid metabolic process GO:0005515//GO:0047396 protein binding//glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.33301 BF_2 453.11 4.27 4722 91084835 XP_966560.1 1369 5.5e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 6.8e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00114//PF04142//PF08449//PF06027//PF00893//PF00892//PF13895 Pilin (bacterial filament)//Nucleotide-sugar transporter//UAA transporter family//Solute carrier family 35//Small Multidrug Resistance protein//EamA-like transporter family//Immunoglobulin domain GO:0008643//GO:0007155//GO:0006810//GO:0055085 carbohydrate transport//cell adhesion//transport//transmembrane transport GO:0005515//GO:0005351 protein binding//sugar:proton symporter activity GO:0016020//GO:0000139//GO:0009289//GO:0016021 membrane//Golgi membrane//pilus//integral component of membrane KOG3912 Predicted integral membrane protein Cluster-8309.33305 BF_2 1156.99 66.32 1017 549438521 AGX25149.1 1278 4.2e-138 purple acid phosphatase-like protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- A5D6U8 929 5.1e-99 Iron/zinc purple acid phosphatase-like protein OS=Danio rerio GN=papl PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG1378 Purple acid phosphatase Cluster-8309.33306 BF_2 12.01 0.59 1143 549438521 AGX25149.1 295 4.6e-24 purple acid phosphatase-like protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q8BX37 196 5.7e-14 Iron/zinc purple acid phosphatase-like protein OS=Mus musculus GN=Papl PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1378 Purple acid phosphatase Cluster-8309.33307 BF_2 32.91 0.39 3847 546677672 ERL88466.1 763 8.4e-78 hypothetical protein D910_05852, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5REC0 135 2.3e-06 Zinc finger C2HC domain-containing protein 1A OS=Pongo abelii GN=ZC2HC1A PE=2 SV=1 PF02964//PF04690//PF01155 Methane monooxygenase, hydrolase gamma chain//YABBY protein//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0007275//GO:0006118//GO:0015947//GO:0006464 multicellular organismal development//obsolete electron transport//methane metabolic process//cellular protein modification process GO:0015049//GO:0016151 methane monooxygenase activity//nickel cation binding GO:0015050 methane monooxygenase complex -- -- Cluster-8309.33308 BF_2 3.00 0.43 581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33311 BF_2 756.88 146.60 503 157112956 XP_001657696.1 485 1.9e-46 AAEL000138-PA [Aedes aegypti]>gi|108884662|gb|EAT48887.1| AAEL000138-PA [Aedes aegypti] -- -- -- -- -- K03950 NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03950 Q02366 311 1.2e-27 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 OS=Bos taurus GN=NDUFA6 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3426 NADH:ubiquinone oxidoreductase, NDUFA6/B14 subunit Cluster-8309.33312 BF_2 70.84 0.53 5925 546676645 ERL87609.1 2223 6.5e-247 hypothetical protein D910_05000, partial [Dendroctonus ponderosae] -- -- -- -- -- K04659 THBS2S thrombospondin 2/3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04659 P49747 1725 1.5e-190 Cartilage oligomeric matrix protein OS=Homo sapiens GN=COMP PE=1 SV=2 PF00008//PF07645//PF05735//PF02412 EGF-like domain//Calcium-binding EGF domain//Thrombospondin C-terminal region//Thrombospondin type 3 repeat GO:0007155 cell adhesion GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.33314 BF_2 1548.57 11.45 5944 642926801 XP_969339.3 2263 1.5e-251 PREDICTED: histone-lysine N-methyltransferase SETD1B [Tribolium castaneum] 768423227 XM_011554208.1 242 8.04371e-121 PREDICTED: Plutella xylostella histone-lysine N-methyltransferase SETD1-like (LOC105384048), mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 1105 1.2e-118 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856//PF00076//PF03490 SET domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0003676//GO:0005515//GO:0047396 nucleic acid binding//protein binding//glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.33315 BF_2 307.74 15.29 1129 91089683 XP_974633.1 613 6.1e-61 PREDICTED: survival of motor neuron-related-splicing factor 30 [Tribolium castaneum]>gi|270011328|gb|EFA07776.1| hypothetical protein TcasGA2_TC005331 [Tribolium castaneum] -- -- -- -- -- K12839 SMNDC1, SPF30 survival of motor neuron-related-splicing factor 30 http://www.genome.jp/dbget-bin/www_bget?ko:K12839 Q7ZV80 181 3.1e-12 Survival of motor neuron-related-splicing factor 30 OS=Danio rerio GN=smndc1 PE=2 SV=1 PF06003 Survival motor neuron protein (SMN) GO:0006397 mRNA processing GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG3026 Splicing factor SPF30 Cluster-8309.33317 BF_2 564.60 9.76 2707 478258665 ENN78715.1 1719 8.2e-189 hypothetical protein YQE_04887, partial [Dendroctonus ponderosae]>gi|546674937|gb|ERL86214.1| hypothetical protein D910_03625 [Dendroctonus ponderosae] -- -- -- -- -- K09527 DNAJC7 DnaJ homolog subfamily C member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09527 Q99615 1161 1.7e-125 DnaJ homolog subfamily C member 7 OS=Homo sapiens GN=DNAJC7 PE=1 SV=2 PF04196//PF13181//PF13174//PF13371//PF00515//PF13374//PF13414//PF13176 Bunyavirus RNA dependent RNA polymerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006351//GO:0019079//GO:0006144 transcription, DNA-templated//viral genome replication//purine nucleobase metabolic process GO:0003968//GO:0005515 RNA-directed RNA polymerase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex KOG0550 Molecular chaperone (DnaJ superfamily) Cluster-8309.33319 BF_2 2158.26 42.81 2396 189238404 XP_001812043.1 1142 5.9e-122 PREDICTED: uncharacterized protein LOC100142307 [Tribolium castaneum]>gi|270009293|gb|EFA05741.1| hypothetical protein TcasGA2_TC015640 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3EWZ6 361 8.8e-33 MAM and LDL-receptor class A domain-containing protein 2 (Fragment) OS=Acropora millepora PE=1 SV=1 PF01033//PF00629 Somatomedin B domain//MAM domain, meprin/A5/mu GO:0006955//GO:0007165 immune response//signal transduction GO:0030247//GO:0005044 polysaccharide binding//scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.33321 BF_2 238.41 2.55 4197 270009832 EFA06280.1 3210 0.0e+00 hypothetical protein TcasGA2_TC009146 [Tribolium castaneum] 686484113 KM036513.1 210 3.4827e-103 Locusta migratoria Mcm5 mRNA, complete cds K02209 MCM5, CDC46 DNA replication licensing factor MCM5 http://www.genome.jp/dbget-bin/www_bget?ko:K02209 Q9VGW6 2924 0.0e+00 DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 PF00493//PF07728//PF07726//PF00158 MCM2/3/5 family//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003677//GO:0016887//GO:0005524//GO:0008134 DNA binding//ATPase activity//ATP binding//transcription factor binding GO:0005667 transcription factor complex KOG0481 DNA replication licensing factor, MCM5 component Cluster-8309.33322 BF_2 70.00 1.77 1946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33323 BF_2 223.00 34.56 557 -- -- -- -- -- 642939072 XM_008201989.1 71 8.15017e-27 PREDICTED: Tribolium castaneum DEAD-box ATP-dependent RNA helicase 20-like (LOC103312134), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33324 BF_2 177.54 1.18 6571 642939071 XP_008200210.1 2224 5.5e-247 PREDICTED: DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [Tribolium castaneum] 158300605 XM_320481.4 215 9.08398e-106 Anopheles gambiae str. PEST AGAP012045-PA (AgaP_AGAP012045) mRNA, complete cds K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1374 8.3e-150 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF00270//PF00816//PF03328//PF04851 DEAD/DEAH box helicase//H-NS histone family//HpcH/HpaI aldolase/citrate lyase family//Type III restriction enzyme, res subunit GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0003824//GO:0003676//GO:0003677//GO:0016787 ATP binding//catalytic activity//nucleic acid binding//DNA binding//hydrolase activity GO:0005622 intracellular KOG0331 ATP-dependent RNA helicase Cluster-8309.33325 BF_2 854.06 7.23 5231 270016924 EFA13370.1 2629 4.8e-294 hypothetical protein TcasGA2_TC001907 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMW5 1504 5.6e-165 Rho GTPase-activating protein 26 OS=Gallus gallus GN=ARHGAP26 PE=1 SV=2 PF03114//PF01297//PF00018//PF14604//PF00620//PF01956//PF03155 BAR domain//Zinc-uptake complex component A periplasmic//SH3 domain//Variant SH3 domain//RhoGAP domain//Integral membrane protein DUF106//ALG6, ALG8 glycosyltransferase family GO:0030001//GO:0007165 metal ion transport//signal transduction GO:0016758//GO:0005515//GO:0046872 transferase activity, transferring hexosyl groups//protein binding//metal ion binding GO:0005789//GO:0016020//GO:0005737 endoplasmic reticulum membrane//membrane//cytoplasm KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.33327 BF_2 28.88 1.13 1359 91076690 XP_971724.1 912 1.6e-95 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 [Tribolium castaneum]>gi|270001870|gb|EEZ98317.1| hypothetical protein TcasGA2_TC000771 [Tribolium castaneum] 645024302 XM_001601194.3 110 4.30959e-48 PREDICTED: Nasonia vitripennis NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 (LOC100116856), mRNA K18162 NDUFAF5 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18162 B2GV71 595 3.7e-60 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5 OS=Rattus norvegicus GN=Ndufaf5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2940 Predicted methyltransferase Cluster-8309.33329 BF_2 927.00 6.76 6023 91093752 XP_969444.1 1063 2.1e-112 PREDICTED: glyoxalase domain-containing protein 4 [Tribolium castaneum]>gi|270013016|gb|EFA09464.1| hypothetical protein TcasGA2_TC010680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5I0D1 786 1.2e-81 Glyoxalase domain-containing protein 4 OS=Rattus norvegicus GN=Glod4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2943 Predicted glyoxalase Cluster-8309.33330 BF_2 24.00 1.01 1282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33332 BF_2 23.20 0.65 1779 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33334 BF_2 501.00 23.24 1189 -- -- -- -- -- 642938152 XM_964275.2 92 3.80977e-38 PREDICTED: Tribolium castaneum neurocalcin homolog (LOC657840), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33336 BF_2 63.54 1.37 2225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33338 BF_2 148.56 7.18 1153 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33339 BF_2 81.33 0.46 7746 642918353 XP_008199964.1 4772 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1PBJ0 2374 1.1e-265 Rap guanine nucleotide exchange factor 2 OS=Canis familiaris GN=RAPGEF2 PE=1 SV=2 PF00788//PF13180//PF00617//PF00595 Ras association (RalGDS/AF-6) domain//PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF) GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.3334 BF_2 3.00 0.47 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33340 BF_2 41.23 1.41 1508 642918353 XP_008199964.1 209 5.7e-14 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33341 BF_2 54.18 0.50 4798 642913175 XP_008201423.1 537 1.7e-51 PREDICTED: uncharacterized protein LOC663955 isoform X2 [Tribolium castaneum] 642913177 XM_008203202.1 165 4.12923e-78 PREDICTED: Tribolium castaneum uncharacterized LOC663955 (LOC663955), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF10384 Centromere protein Scm3 -- -- GO:0042393 histone binding GO:0005634 nucleus -- -- Cluster-8309.33342 BF_2 19.44 0.35 2608 546678936 ERL89474.1 1255 5.1e-135 hypothetical protein D910_06840 [Dendroctonus ponderosae] 462304202 APGK01049574.1 91 3.05513e-37 Dendroctonus ponderosae Seq01049584, whole genome shotgun sequence K14206 SLC15A1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14206 P91679 673 6.4e-69 Peptide transporter family 1 OS=Drosophila melanogaster GN=yin PE=1 SV=2 PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1237 H+/oligopeptide symporter Cluster-8309.33344 BF_2 1361.25 14.77 4143 642924817 XP_008194053.1 3651 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X5 [Tribolium castaneum] 749755570 XM_011141969.1 132 7.87415e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.2e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.33345 BF_2 134.40 1.56 3897 642924813 XP_008194051.1 3162 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X3 [Tribolium castaneum] 749755570 XM_011141969.1 132 7.40251e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 4.9e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.33347 BF_2 107.82 1.55 3198 642926068 XP_008194752.1 3795 0.0e+00 PREDICTED: calsyntenin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V498 1582 3.1e-174 Calsyntenin-1 OS=Drosophila melanogaster GN=Cals PE=1 SV=2 PF07953//PF00722//PF00028 Clostridium neurotoxin, N-terminal receptor binding//Glycosyl hydrolases family 16//Cadherin domain GO:0005975//GO:0051609//GO:0007165//GO:0009405//GO:0007156 carbohydrate metabolic process//inhibition of neurotransmitter uptake//signal transduction//pathogenesis//homophilic cell adhesion via plasma membrane adhesion molecules GO:0050827//GO:0005509//GO:0004222//GO:0004553 toxin receptor binding//calcium ion binding//metalloendopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576//GO:0016020 extracellular region//membrane KOG1834 Calsyntenin Cluster-8309.33349 BF_2 38.76 0.44 3981 642921429 XP_974248.2 1025 3.6e-108 PREDICTED: uncharacterized protein LOC663094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4KMD7 279 4.7e-23 Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Danio rerio GN=tut1 PE=2 SV=1 PF08039//PF09128 Mitochondrial proteolipid//Regulator of G protein signalling-like domain GO:0043087 regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0005739//GO:0005737 mitochondrion//cytoplasm KOG2277 S-M checkpoint control protein CID1 and related nucleotidyltransferases Cluster-8309.33350 BF_2 375.49 10.53 1779 270014882 EFA11330.1 1355 8.7e-147 hypothetical protein TcasGA2_TC010869 [Tribolium castaneum] -- -- -- -- -- K01349 FURIN, PCSK3 furin http://www.genome.jp/dbget-bin/www_bget?ko:K01349 P26016 1028 3.0e-110 Furin-like protease 1, isoforms 1/1-X/2 OS=Drosophila melanogaster GN=Fur1 PE=2 SV=2 PF01483//PF00082 Proprotein convertase P-domain//Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3525 Subtilisin-like proprotein convertase Cluster-8309.33351 BF_2 100.50 27.96 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33352 BF_2 2936.00 78.09 1860 332374558 AEE62420.1 2409 5.5e-269 unknown [Dendroctonus ponderosae] 871221006 XM_013080402.1 252 6.86192e-127 PREDICTED: Aplysia californica T-complex protein 1 subunit alpha-like (LOC101853150), mRNA K09493 CCT1, TCP1 T-complex protein 1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09493 P12613 2275 7.8e-255 T-complex protein 1 subunit alpha OS=Drosophila melanogaster GN=T-cp1 PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0360 Chaperonin complex component, TCP-1 alpha subunit (CCT1) Cluster-8309.33353 BF_2 55.47 2.19 1349 270008843 EFA05291.1 961 3.2e-101 hypothetical protein TcasGA2_TC015448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 260 2.6e-21 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33355 BF_2 743.08 26.39 1465 91076380 XP_968185.1 1749 1.5e-192 PREDICTED: interleukin enhancer-binding factor 2 homolog [Tribolium castaneum]>gi|270002554|gb|EEZ99001.1| hypothetical protein TcasGA2_TC004865 [Tribolium castaneum] 332373637 BT126998.1 276 2.44902e-140 Dendroctonus ponderosae clone DPO1124_K05 unknown mRNA K13089 ILF2 interleukin enhancer-binding factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13089 Q9VG73 1299 9.2e-142 Interleukin enhancer-binding factor 2 homolog OS=Drosophila melanogaster GN=CG5641 PE=2 SV=1 -- -- GO:0006955 immune response GO:0016740//GO:0003723//GO:0005524 transferase activity//RNA binding//ATP binding -- -- KOG3793 Transcription factor NFAT, subunit NF45 Cluster-8309.33356 BF_2 137.55 3.72 1832 91090252 XP_969934.1 425 6.2e-39 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 2.1e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.33360 BF_2 264.02 3.78 3206 642911078 XP_008200566.1 2414 2.5e-269 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 763 2.9e-79 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF13442//PF00641//PF01585//PF07808//PF11648//PF00076 Cytochrome C oxidase, cbb3-type, subunit III//Zn-finger in Ran binding protein and others//G-patch domain//RED-like protein N-terminal region//C-terminal domain of RIG-I//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006118 obsolete electron transport GO:0003676//GO:0000166//GO:0008270//GO:0009055//GO:0016817//GO:0020037 nucleic acid binding//nucleotide binding//zinc ion binding//electron carrier activity//hydrolase activity, acting on acid anhydrides//heme binding GO:0005634//GO:0005622 nucleus//intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.33362 BF_2 92.00 5.44 995 801370811 XP_012060089.1 150 2.6e-07 PREDICTED: uncharacterized protein LOC105623298 [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33364 BF_2 173.63 2.12 3716 270010575 EFA07023.1 1789 8.6e-197 hypothetical protein TcasGA2_TC009994 [Tribolium castaneum] -- -- -- -- -- K11324 DMAP1, SWC4, EAF2 DNA methyltransferase 1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11324 Q9JI44 1182 8.6e-128 DNA methyltransferase 1-associated protein 1 OS=Mus musculus GN=Dmap1 PE=1 SV=1 PF05499 DNA methyltransferase 1-associated protein 1 (DMAP1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2656 DNA methyltransferase 1-associated protein-1 Cluster-8309.33367 BF_2 2080.65 63.12 1666 332374052 AEE62167.1 903 2.1e-94 unknown [Dendroctonus ponderosae]>gi|478263264|gb|ENN81648.1| hypothetical protein YQE_01946, partial [Dendroctonus ponderosae]>gi|546673295|gb|ERL84927.1| hypothetical protein D910_02350 [Dendroctonus ponderosae] 551506028 XM_005804490.1 134 2.41811e-61 PREDICTED: Xiphophorus maculatus ubiquitin-conjugating enzyme E2 E2-like (LOC102229941), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P52485 836 5.1e-88 Ubiquitin-conjugating enzyme E2-24 kDa OS=Drosophila melanogaster GN=UbcD2 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.33370 BF_2 95.00 3.27 1501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33371 BF_2 23.61 0.55 2079 91094295 XP_971662.1 1530 5.2e-167 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 P81140 1353 7.2e-148 Glutaryl-CoA dehydrogenase, mitochondrial (Fragment) OS=Sus scrofa GN=GCDH PE=1 SV=1 PF00441//PF07180//PF02771//PF02770 Acyl-CoA dehydrogenase, C-terminal domain//Protein of unknown function (DUF1401)//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0006118//GO:0006351//GO:0008152//GO:0055114 obsolete electron transport//transcription, DNA-templated//metabolic process//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.33372 BF_2 353.34 11.18 1609 91094295 XP_971662.1 1667 5.2e-183 PREDICTED: glutaryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014404|gb|EFA10852.1| hypothetical protein TcasGA2_TC001629 [Tribolium castaneum] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 1449 4.1e-159 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.33374 BF_2 1.00 16.49 221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33378 BF_2 1459.39 5.55 11294 642936312 XP_008198391.1 8183 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 9.75812e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3630 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF14604//PF00018//PF01608//PF07651//PF03822 Variant SH3 domain//SH3 domain//I/LWEQ domain//ANTH domain//NAF domain GO:0007165 signal transduction GO:0003779//GO:0005515//GO:0005543 actin binding//protein binding//phospholipid binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.33379 BF_2 339.76 1.48 9873 642936312 XP_008198391.1 6193 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 8.52633e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 2619 5.4e-294 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF07651//PF01608//PF03822 ANTH domain//I/LWEQ domain//NAF domain GO:0007165 signal transduction GO:0005543//GO:0003779 phospholipid binding//actin binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.33380 BF_2 1015.61 13.90 3343 642916840 XP_008199525.1 1090 8.8e-116 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X3 [Tribolium castaneum] 170068311 XM_001868784.1 204 5.99147e-100 Culex quinquefasciatus serine/threonine-protein phosphatase 2B catalytic subunit 2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 933 5.8e-99 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.33381 BF_2 323.40 6.71 2303 642916834 XP_008199522.1 590 5.8e-58 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum]>gi|642916836|ref|XP_008199523.1| PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum] 642916835 XM_008201301.1 191 6.9269e-93 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2B catalytic subunit 2-like (LOC657135), transcript variant X2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 460 2.8e-44 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.33383 BF_2 206.52 5.79 1780 642923490 XP_008193532.1 1769 8.6e-195 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 75 1.62456e-28 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 1234 3.9e-134 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0008417 fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.33385 BF_2 2323.17 18.22 5620 642924099 XP_008194004.1 1477 2.0e-160 PREDICTED: division abnormally delayed protein [Tribolium castaneum] 642924098 XM_008195782.1 56 1.8958e-17 PREDICTED: Tribolium castaneum division abnormally delayed protein (LOC656854), mRNA K02306 DALLY dally http://www.genome.jp/dbget-bin/www_bget?ko:K02306 Q24114 730 3.4e-75 Division abnormally delayed protein OS=Drosophila melanogaster GN=dally PE=1 SV=1 PF07657//PF01392//PF01153 N terminus of Notch ligand//Fz domain//Glypican GO:0007219//GO:0007275 Notch signaling pathway//multicellular organismal development GO:0005515//GO:0043395 protein binding//heparan sulfate proteoglycan binding GO:0016021//GO:0005578//GO:0016020 integral component of membrane//proteinaceous extracellular matrix//membrane -- -- Cluster-8309.33387 BF_2 444.00 6.73 3045 642922001 XP_008192976.1 1182 1.7e-126 PREDICTED: homeobox protein SIX2 [Tribolium castaneum] 699693291 XM_009891221.1 243 1.13905e-121 PREDICTED: Charadrius vociferus SIX homeobox 1 (SIX1), partial mRNA K15614 SIX1 homeobox protein SIX1 http://www.genome.jp/dbget-bin/www_bget?ko:K15614 Q27350 935 3.1e-99 Protein sine oculis OS=Drosophila melanogaster GN=so PE=2 SV=1 PF05920//PF02159//PF01381//PF00046//PF03964 Homeobox KN domain//Oestrogen receptor//Helix-turn-helix//Homeobox domain//Chorion family 2 GO:0007165//GO:0007275//GO:0006355//GO:0043401 signal transduction//multicellular organismal development//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003677//GO:0005496//GO:0030284//GO:0043565 DNA binding//steroid binding//estrogen receptor activity//sequence-specific DNA binding GO:0005634//GO:0042600 nucleus//chorion KOG0775 Transcription factor SIX and related HOX domain proteins Cluster-8309.33388 BF_2 22.85 0.49 2258 91087901 XP_970608.1 817 2.7e-84 PREDICTED: protein cereblon [Tribolium castaneum]>gi|270012017|gb|EFA08465.1| hypothetical protein TcasGA2_TC006114 [Tribolium castaneum] -- -- -- -- -- K11793 CRBN cereblon http://www.genome.jp/dbget-bin/www_bget?ko:K11793 P0CF65 275 7.8e-23 Protein cereblon OS=Gallus gallus GN=CRBN PE=1 SV=1 PF02190//PF02202 ATP-dependent protease La (LON) substrate-binding domain//Tachykinin family GO:0006508//GO:0007217//GO:0007268//GO:0006510 proteolysis//tachykinin receptor signaling pathway//synaptic transmission//obsolete ATP-dependent proteolysis GO:0004176 ATP-dependent peptidase activity -- -- KOG1400 Predicted ATP-dependent protease PIL, contains LON domain Cluster-8309.33392 BF_2 129.39 38.53 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33393 BF_2 325.63 3.89 3791 642924780 XP_975331.2 997 6.1e-105 PREDICTED: protein FAM122A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZLN7 147 9.1e-08 Protein FAM122A OS=Gallus gallus GN=FAM122A PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33395 BF_2 1810.68 63.82 1474 91091796 XP_970426.1 890 6.0e-93 PREDICTED: dynactin subunit 4 [Tribolium castaneum]>gi|270001091|gb|EEZ97538.1| hypothetical protein TcasGA2_TC011388 [Tribolium castaneum] -- -- -- -- -- K10426 DCTN4 dynactin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10426 Q9QUR2 319 4.0e-28 Dynactin subunit 4 OS=Rattus norvegicus GN=Dctn4 PE=1 SV=1 PF02529 Cytochrome B6-F complex subunit 5 -- -- -- -- GO:0009512 cytochrome b6f complex -- -- Cluster-8309.33397 BF_2 672.15 25.24 1401 642937984 XP_008199157.1 229 2.5e-16 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33398 BF_2 484.08 14.07 1726 642930472 XP_008196416.1 937 2.5e-98 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 777 3.7e-81 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.33399 BF_2 103.87 2.22 2244 642922794 XP_008193328.1 1279 7.2e-138 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 723 8.7e-75 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.334 BF_2 2.13 0.54 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33400 BF_2 12.59 0.48 1389 642930472 XP_008196416.1 644 1.9e-64 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 548 1.1e-54 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.33402 BF_2 748.80 3.02 10649 642911064 XP_008200559.1 6648 0.0e+00 PREDICTED: nipped-B-like protein isoform X1 [Tribolium castaneum]>gi|270014671|gb|EFA11119.1| hypothetical protein TcasGA2_TC004719 [Tribolium castaneum] 766925181 XM_011496172.1 131 7.31538e-59 PREDICTED: Ceratosolen solmsi marchali nipped-B-like protein A (LOC105359557), mRNA K06672 SCC2, NIPBL cohesin loading factor subunit SCC2 http://www.genome.jp/dbget-bin/www_bget?ko:K06672 Q6KC79 3335 0.0e+00 Nipped-B-like protein OS=Homo sapiens GN=NIPBL PE=1 SV=2 PF02985//PF05875//PF02532 HEAT repeat//Ceramidase//Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979//GO:0006672//GO:0006807 photosynthesis//ceramide metabolic process//nitrogen compound metabolic process GO:0016811//GO:0005515 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//protein binding GO:0016021//GO:0016020//GO:0009523//GO:0009539 integral component of membrane//membrane//photosystem II//photosystem II reaction center KOG1020 Sister chromatid cohesion protein SCC2/Nipped-B Cluster-8309.33403 BF_2 283.21 0.90 13408 642911254 XP_008199787.1 11406 0.0e+00 PREDICTED: filamin-A isoform X1 [Tribolium castaneum] 642911253 XM_008201565.1 2003 0 PREDICTED: Tribolium castaneum filamin-A (LOC661488), transcript variant X1, mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q9VEN1 5214 0.0e+00 Filamin-A OS=Drosophila melanogaster GN=cher PE=1 SV=2 PF00307//PF00688//PF01105 Calponin homology (CH) domain//TGF-beta propeptide//emp24/gp25L/p24 family/GOLD GO:0006810//GO:0008283//GO:0040007//GO:0007165 transport//cell proliferation//growth//signal transduction GO:0005515//GO:0008083 protein binding//growth factor activity GO:0016021 integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.33404 BF_2 384.59 24.68 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33407 BF_2 1970.00 62.34 1609 642912027 XP_008199065.1 1139 8.8e-122 PREDICTED: aldose 1-epimerase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K01785 galM, GALM aldose 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01785 Q5EA79 798 1.3e-83 Aldose 1-epimerase OS=Bos taurus GN=GALM PE=2 SV=1 PF01263 Aldose 1-epimerase GO:0005975 carbohydrate metabolic process GO:0016853 isomerase activity -- -- KOG1604 Predicted mutarotase Cluster-8309.33410 BF_2 4599.48 103.79 2141 91085815 XP_974770.1 1408 7.5e-153 PREDICTED: maternal protein exuperantia-1 [Tribolium castaneum]>gi|270011046|gb|EFA07494.1| exuperantia [Tribolium castaneum] -- -- -- -- -- K18745 EXU maternal protein exuperantia http://www.genome.jp/dbget-bin/www_bget?ko:K18745 Q24747 596 4.4e-60 Maternal protein exuperantia OS=Drosophila virilis GN=exu PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33412 BF_2 12.00 0.59 1144 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33415 BF_2 45.90 0.42 4862 91092640 XP_969145.1 2951 0.0e+00 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.3e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0043169//GO:0005515 cation binding//protein binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.33417 BF_2 243.46 2.59 4214 170032167 XP_001843954.1 913 3.7e-95 conserved hypothetical protein [Culex quinquefasciatus]>gi|167871903|gb|EDS35286.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P30839 745 4.6e-77 Fatty aldehyde dehydrogenase OS=Rattus norvegicus GN=Aldh3a2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0006570//GO:0006081//GO:0008152//GO:0006096//GO:0055114//GO:0006547//GO:0006094//GO:0006558 tyrosine metabolic process//cellular aldehyde metabolic process//metabolic process//glycolytic process//oxidation-reduction process//histidine metabolic process//gluconeogenesis//L-phenylalanine metabolic process GO:0016491//GO:0004030 oxidoreductase activity//aldehyde dehydrogenase [NAD(P)+] activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.33418 BF_2 18.16 0.42 2091 642930433 XP_008196400.1 386 2.4e-34 PREDICTED: death-associated protein 1 [Tribolium castaneum]>gi|270010727|gb|EFA07175.1| hypothetical protein TcasGA2_TC010175 [Tribolium castaneum] -- -- -- -- -- K03104 SRP14 signal recognition particle subunit SRP14 http://www.genome.jp/dbget-bin/www_bget?ko:K03104 A6QQL9 236 2.4e-18 Signal recognition particle 14 kDa protein OS=Bos taurus GN=SRP14 PE=3 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942 7S RNA binding//endoplasmic reticulum signal peptide binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG1761 Signal recognition particle, subunit Srp14 Cluster-8309.33419 BF_2 1971.22 62.20 1613 642930433 XP_008196400.1 445 2.6e-41 PREDICTED: death-associated protein 1 [Tribolium castaneum]>gi|270010727|gb|EFA07175.1| hypothetical protein TcasGA2_TC010175 [Tribolium castaneum] -- -- -- -- -- K03104 SRP14 signal recognition particle subunit SRP14 http://www.genome.jp/dbget-bin/www_bget?ko:K03104 A6QQL9 236 1.9e-18 Signal recognition particle 14 kDa protein OS=Bos taurus GN=SRP14 PE=3 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0030942//GO:0008312 endoplasmic reticulum signal peptide binding//7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG1761 Signal recognition particle, subunit Srp14 Cluster-8309.33420 BF_2 27.22 0.71 1892 642930433 XP_008196400.1 445 3.1e-41 PREDICTED: death-associated protein 1 [Tribolium castaneum]>gi|270010727|gb|EFA07175.1| hypothetical protein TcasGA2_TC010175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51397 178 1.2e-11 Death-associated protein 1 OS=Homo sapiens GN=DAP PE=1 SV=3 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942 7S RNA binding//endoplasmic reticulum signal peptide binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting -- -- Cluster-8309.33421 BF_2 5.82 0.45 828 805784468 XP_003703131.2 617 1.5e-61 PREDICTED: 60S ribosomal protein L9 [Megachile rotundata] 264667320 GU120396.1 153 3.22802e-72 Chrysomela tremulae ribosomal protein L9 (RpL9) mRNA, complete cds K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 Q963B7 568 3.0e-57 60S ribosomal protein L9 OS=Spodoptera frugiperda GN=RpL9 PE=2 SV=1 PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-8309.33422 BF_2 24.00 0.34 3241 478253163 ENN73534.1 191 1.5e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF13912//PF16622//PF13465//PF02701//PF07503//PF03811//PF00096//PF02176//PF05495 BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Dof domain, zinc finger//HypF finger//InsA N-terminal domain//Zinc finger, C2H2 type//TRAF-type zinc finger//CHY zinc finger GO:0006355//GO:0006313 regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.33425 BF_2 340.05 4.04 3805 270010190 EFA06638.1 2387 4.0e-266 hypothetical protein TcasGA2_TC009560, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UH06 502 6.3e-49 Ras-responsive element-binding protein 1 OS=Mus musculus GN=Rreb1 PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.33428 BF_2 352.00 7.68 2205 642912957 XP_008201325.1 377 2.8e-33 PREDICTED: leucine-rich repeat-containing protein let-4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TJ59 205 1.0e-14 Toll-like receptor 3 OS=Bos taurus GN=TLR3 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33430 BF_2 96.25 2.08 2225 642925464 XP_008194565.1 397 1.3e-35 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.33433 BF_2 16.04 0.34 2266 478252289 ENN72716.1 268 1.2e-20 hypothetical protein YQE_10654, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7M4F1 184 2.8e-12 Endocuticle structural glycoprotein SgAbd-4 OS=Schistocerca gregaria PE=1 SV=1 PF13184 NusA-like KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.33434 BF_2 1730.00 46.91 1830 91078026 XP_970646.1 2311 1.3e-257 PREDICTED: T-complex protein 1 subunit beta [Tribolium castaneum]>gi|270001410|gb|EEZ97857.1| hypothetical protein TcasGA2_TC000229 [Tribolium castaneum] 167526083 XM_001747324.1 111 1.62448e-48 Monosiga brevicollis MX1 predicted protein MONBRDRAFT_33089 mRNA, complete cds K09494 CCT2 T-complex protein 1 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K09494 Q3ZBH0 1941 4.1e-216 T-complex protein 1 subunit beta OS=Bos taurus GN=CCT2 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0005737 cytoplasm KOG0363 Chaperonin complex component, TCP-1 beta subunit (CCT2) Cluster-8309.33435 BF_2 7.31 0.37 1117 478250090 ENN70596.1 718 4.0e-73 hypothetical protein YQE_12771, partial [Dendroctonus ponderosae] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 O97758 168 9.8e-11 Tight junction protein ZO-1 OS=Canis familiaris GN=TJP1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33437 BF_2 943.00 21.74 2102 91094301 XP_971831.1 650 5.8e-65 PREDICTED: uncharacterized protein LOC660513 [Tribolium castaneum]>gi|270014382|gb|EFA10830.1| hypothetical protein TcasGA2_TC001606 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33438 BF_2 15.00 0.40 1842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33440 BF_2 2096.45 122.68 1002 332372870 AEE61577.1 250 6.7e-19 unknown [Dendroctonus ponderosae]>gi|478256263|gb|ENN76453.1| hypothetical protein YQE_06907, partial [Dendroctonus ponderosae]>gi|546679245|gb|ERL89739.1| hypothetical protein D910_07100 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D1L0 168 8.8e-11 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 OS=Mus musculus GN=Chchd2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4090 Uncharacterized conserved protein Cluster-8309.33441 BF_2 255.38 6.58 1910 189239542 XP_001816493.1 505 3.4e-48 PREDICTED: uncharacterized protein LOC100141605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33443 BF_2 270.99 6.46 2043 642912011 XP_008199059.1 951 7.0e-100 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PE2 530 1.9e-52 Rho guanine nucleotide exchange factor 17 OS=Homo sapiens GN=ARHGEF17 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.33444 BF_2 6421.19 98.47 3015 478262467 ENN81138.1 1903 4.2e-210 hypothetical protein YQE_02505, partial [Dendroctonus ponderosae] -- -- -- -- -- K14258 TRET1 facilitated trehalose transporter http://www.genome.jp/dbget-bin/www_bget?ko:K14258 Q17NV8 1407 5.7e-154 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF00083//PF07690//PF06849 Sugar (and other) transporter//Major Facilitator Superfamily//Protein of unknown function (DUF1246) GO:0006188//GO:0055085 IMP biosynthetic process//transmembrane transport GO:0000287//GO:0016879//GO:0022857//GO:0005524 magnesium ion binding//ligase activity, forming carbon-nitrogen bonds//transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33447 BF_2 2592.34 30.88 3799 91079594 XP_967887.1 1746 8.6e-192 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.51812e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 5.3e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.33448 BF_2 163.57 1.96 3774 91079594 XP_967887.1 1746 8.5e-192 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] 194884182 XM_001976139.1 162 1.50803e-76 Drosophila erecta GG22721 (Dere\GG22721), mRNA K11975 RNF144 E3 ubiquitin-protein ligase RNF144 http://www.genome.jp/dbget-bin/www_bget?ko:K11975 Q925F3 770 5.2e-80 E3 ubiquitin-protein ligase RNF144A OS=Mus musculus GN=Rnf144a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.33451 BF_2 920.93 6.57 6155 478252889 ENN73274.1 3178 0.0e+00 hypothetical protein YQE_10104, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 6.6e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.33452 BF_2 41.63 0.70 2760 270004742 EFA01190.1 2041 3.9e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 9.1e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0006090 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.33455 BF_2 84.44 2.49 1707 478250970 ENN71454.1 937 2.5e-98 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 539 1.4e-53 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF03153//PF04546 Transcription factor IIA, alpha/beta subunit//Sigma-70, non-essential region GO:0006355//GO:0006367//GO:0006352 regulation of transcription, DNA-templated//transcription initiation from RNA polymerase II promoter//DNA-templated transcription, initiation GO:0003677//GO:0016987//GO:0003700 DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005672 transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.33456 BF_2 1036.00 14.21 3338 642927268 XP_008195200.1 1817 4.4e-200 PREDICTED: poly(A) RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270009992|gb|EFA06440.1| hypothetical protein TcasGA2_TC009322 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDN6 793 9.9e-83 Thioredoxin-like protein 1 OS=Mus musculus GN=Txnl1 PE=2 SV=3 PF01909//PF00085//PF00578 Nucleotidyltransferase domain//Thioredoxin//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0016491//GO:0016779 antioxidant activity//oxidoreductase activity//nucleotidyltransferase activity -- -- KOG0908 Thioredoxin-like protein Cluster-8309.33457 BF_2 979.58 19.66 2371 91092940 XP_972197.1 1829 1.3e-201 PREDICTED: ubiquitin carboxyl-terminal hydrolase 10 [Tribolium castaneum]>gi|270004786|gb|EFA01234.1| ubiquitin-specific protease [Tribolium castaneum] 769845732 XM_011635837.1 42 4.80853e-10 PREDICTED: Pogonomyrmex barbatus ubiquitin carboxyl-terminal hydrolase 10 (LOC105425187), mRNA K11841 USP10, UBP3 ubiquitin carboxyl-terminal hydrolase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K11841 Q5ZJN4 889 5.2e-94 Ubiquitin carboxyl-terminal hydrolase 10 OS=Gallus gallus GN=USP10 PE=2 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0006511//GO:0016579 ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0036459//GO:0004221//GO:0008233 ubiquitinyl hydrolase activity//obsolete ubiquitin thiolesterase activity//peptidase activity -- -- KOG1871 Ubiquitin-specific protease Cluster-8309.33458 BF_2 37.02 0.61 2833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33459 BF_2 520.16 19.38 1410 642922794 XP_008193328.1 1036 6.8e-110 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 572 1.8e-57 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.33460 BF_2 79.36 2.05 1908 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33463 BF_2 1820.19 23.13 3579 91082533 XP_973629.1 1814 1.0e-199 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X1 [Tribolium castaneum]>gi|270007557|gb|EFA04005.1| hypothetical protein TcasGA2_TC014154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 879 1.1e-92 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.33464 BF_2 146.82 1.49 4423 478251314 ENN71782.1 3494 0.0e+00 hypothetical protein YQE_11516, partial [Dendroctonus ponderosae]>gi|546673516|gb|ERL85102.1| hypothetical protein D910_02524 [Dendroctonus ponderosae] -- -- -- -- -- K14569 BMS1 ribosome biogenesis protein BMS1 http://www.genome.jp/dbget-bin/www_bget?ko:K14569 Q14692 1364 8.1e-149 Ribosome biogenesis protein BMS1 homolog OS=Homo sapiens GN=BMS1 PE=1 SV=1 PF08142 AARP2CN (NUC121) domain GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1951 GTP-binding protein AARP2 involved in 40S ribosome biogenesis Cluster-8309.33465 BF_2 46.40 2.50 1064 478253273 ENN73644.1 200 4.4e-13 hypothetical protein YQE_09890, partial [Dendroctonus ponderosae]>gi|546676325|gb|ERL87352.1| hypothetical protein D910_04747 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33466 BF_2 36.78 0.89 2019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33468 BF_2 1037.00 23.00 2173 91093403 XP_966518.1 2192 9.4e-244 PREDICTED: inosine-5'-monophosphate dehydrogenase [Tribolium castaneum]>gi|270015409|gb|EFA11857.1| hypothetical protein TcasGA2_TC005099 [Tribolium castaneum] 389612629 AK403490.1 77 1.5387e-29 Papilio xuthus mRNA, raspberry, sequence id: Px-1664, expressed in epidermis K00088 guaB IMP dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00088 Q07152 1975 5.6e-220 Inosine-5'-monophosphate dehydrogenase OS=Drosophila melanogaster GN=ras PE=1 SV=1 PF00218//PF00977//PF01081//PF04309//PF03060//PF01070//PF00478//PF01645//PF04131//PF01180 Indole-3-glycerol phosphate synthase//Histidine biosynthesis protein//KDPG and KHG aldolase//Glycerol-3-phosphate responsive antiterminator//Nitronate monooxygenase//FMN-dependent dehydrogenase//IMP dehydrogenase / GMP reductase domain//Conserved region in glutamate synthase//Putative N-acetylmannosamine-6-phosphate epimerase//Dihydroorotate dehydrogenase GO:0006537//GO:0006571//GO:0055114//GO:0006355//GO:0009607//GO:0006177//GO:0006051//GO:0006144//GO:0008152//GO:0006040//GO:0006807//GO:0000105//GO:0000162//GO:0009094 glutamate biosynthetic process//tyrosine biosynthetic process//oxidation-reduction process//regulation of transcription, DNA-templated//response to biotic stimulus//GMP biosynthetic process//N-acetylmannosamine metabolic process//purine nucleobase metabolic process//metabolic process//amino sugar metabolic process//nitrogen compound metabolic process//histidine biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process GO:0018580//GO:0004425//GO:0047465//GO:0016627//GO:0016638//GO:0003938//GO:0016829//GO:0000166//GO:0016491//GO:0003824//GO:0015930//GO:0046872 nitronate monooxygenase activity//indole-3-glycerol-phosphate synthase activity//N-acylglucosamine-6-phosphate 2-epimerase activity//oxidoreductase activity, acting on the CH-CH group of donors//oxidoreductase activity, acting on the CH-NH2 group of donors//IMP dehydrogenase activity//lyase activity//nucleotide binding//oxidoreductase activity//catalytic activity//glutamate synthase activity//metal ion binding GO:0005737//GO:0042720 cytoplasm//mitochondrial inner membrane peptidase complex KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.33471 BF_2 1161.00 81.65 882 91084965 XP_971914.1 889 4.7e-93 PREDICTED: transmembrane emp24 domain-containing protein 2 [Tribolium castaneum]>gi|270009004|gb|EFA05452.1| hypothetical protein TcasGA2_TC015633 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SXK3 719 1.0e-74 Transmembrane emp24 domain-containing protein OS=Nematostella vectensis GN=v1g194562 PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1692 Putative cargo transport protein EMP24 (p24 protein family) Cluster-8309.33474 BF_2 630.37 14.06 2163 270013786 EFA10234.1 1624 6.8e-178 hypothetical protein TcasGA2_TC012431 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 232 7.2e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33475 BF_2 903.59 32.76 1441 642933527 XP_008197456.1 898 7.0e-94 PREDICTED: protein alan shepard isoform X3 [Tribolium castaneum] 462283408 APGK01056946.1 55 1.71737e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 4.2e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF00076//PF09726//PF07267 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein//Nucleopolyhedrovirus capsid protein P87 -- -- GO:0003676 nucleic acid binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG4733 FOG: RRM domain Cluster-8309.33477 BF_2 142.49 0.76 8130 642923740 XP_008193866.1 1948 6.9e-215 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X8 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O35547 1209 1.4e-130 Long-chain-fatty-acid--CoA ligase 4 OS=Rattus norvegicus GN=Acsl4 PE=1 SV=1 PF09259//PF06624//PF00908//PF15138//PF00501 Fungal immunomodulatory protein Fve//Ribosome associated membrane protein RAMP4//dTDP-4-dehydrorhamnose 3,5-epimerase//Syncollin//AMP-binding enzyme GO:0002682//GO:0006887//GO:0009117//GO:0019872//GO:0008152//GO:0030639 regulation of immune system process//exocytosis//nucleotide metabolic process//streptomycin biosynthetic process//metabolic process//polyketide biosynthetic process GO:0008830//GO:0030246//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//carbohydrate binding//catalytic activity GO:0005783//GO:0030667 endoplasmic reticulum//secretory granule membrane KOG1180 Acyl-CoA synthetase Cluster-8309.33479 BF_2 2457.79 39.24 2907 642923730 XP_008193860.1 3102 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X3 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O95573 1652 2.1e-182 Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens GN=ACSL3 PE=1 SV=3 PF00501//PF00908 AMP-binding enzyme//dTDP-4-dehydrorhamnose 3,5-epimerase GO:0008152//GO:0019872//GO:0030639//GO:0009117 metabolic process//streptomycin biosynthetic process//polyketide biosynthetic process//nucleotide metabolic process GO:0008830//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//catalytic activity -- -- KOG1180 Acyl-CoA synthetase Cluster-8309.33480 BF_2 946.00 8.71 4829 817051760 XP_012252721.1 4480 0.0e+00 PREDICTED: protein strawberry notch isoform X2 [Athalia rosae] 751787619 XM_011204931.1 333 1.69045e-171 PREDICTED: Bactrocera dorsalis protein strawberry notch (LOC105226145), transcript variant X2, mRNA -- -- -- -- A3KN83 3450 0.0e+00 Protein strawberry notch homolog 1 OS=Homo sapiens GN=SBNO1 PE=1 SV=1 PF04851 Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- KOG1513 Nuclear helicase MOP-3/SNO (DEAD-box superfamily) Cluster-8309.33482 BF_2 121.58 0.63 8366 546677296 ERL88157.1 1170 1.2e-124 hypothetical protein D910_05545 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 376 5.6e-34 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33484 BF_2 5.00 0.80 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33486 BF_2 33.63 8.08 461 642912272 XP_008200632.1 155 3.2e-08 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.33489 BF_2 1124.59 55.23 1139 579339789 EUT90581.1 143 1.9e-06 hypothetical protein PFAG_00937 [Plasmodium falciparum Santa Lucia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33490 BF_2 138.00 1.87 3373 270005992 EFA02440.1 870 2.9e-90 hypothetical protein TcasGA2_TC008127 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33491 BF_2 81.94 2.32 1762 260780876 XP_002585561.1 655 1.3e-65 hypothetical protein BRAFLDRAFT_133163 [Branchiostoma floridae]>gi|229270566|gb|EEN41572.1| hypothetical protein BRAFLDRAFT_133163 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q96IR2 588 3.1e-59 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.33496 BF_2 37.79 0.91 2027 270014168 EFA10616.1 234 9.7e-17 hypothetical protein TcasGA2_TC012878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33497 BF_2 210.34 1.76 5296 91090764 XP_969066.1 4523 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X3 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 3.7e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.33498 BF_2 23.00 1.91 792 762109106 XP_011437202.1 265 9.6e-21 PREDICTED: actin-like [Crassostrea gigas] 9501242 AJ292554.1 129 6.76568e-59 Daphnia magna mRNA for actin K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 O42161 265 3.9e-22 Actin, cytoplasmic 1 OS=Salmo salar GN=actb PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.33499 BF_2 325.00 7.35 2137 91077514 XP_969829.1 2169 4.3e-241 PREDICTED: ras association domain-containing protein 4 [Tribolium castaneum] 642914070 XM_964736.3 180 8.36363e-87 PREDICTED: Tribolium castaneum ras association domain-containing protein 4 (LOC658338), mRNA K09851 RASSF2_4 Ras association domain-containing protein 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K09851 Q566C5 331 2.4e-29 Ras association domain-containing protein 4 OS=Rattus norvegicus GN=Rassf4 PE=2 SV=1 PF16517//PF00788//PF00412 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain//Ras association (RalGDS/AF-6) domain//LIM domain GO:0007165 signal transduction GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.33501 BF_2 94.93 2.82 1694 642929884 XP_008196012.1 683 7.0e-69 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 214 6.9e-16 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33502 BF_2 213.92 11.65 1055 642915229 XP_008190531.1 936 2.0e-98 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09101 548 8.0e-55 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33503 BF_2 188.52 1.35 6138 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.1e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF01331//PF09266//PF01279//PF13606//PF00023 mRNA capping enzyme, catalytic domain//Viral DNA topoisomerase I, N-terminal//Parathyroid hormone family//Ankyrin repeat//Ankyrin repeat GO:0006397//GO:0007165//GO:0006265//GO:0006370 mRNA processing//signal transduction//DNA topological change//7-methylguanosine mRNA capping GO:0004484//GO:0005515//GO:0005179//GO:0003916//GO:0003677 mRNA guanylyltransferase activity//protein binding//hormone activity//DNA topoisomerase activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.33506 BF_2 611.00 24.75 1320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02109 DAD family GO:0018279 protein N-linked glycosylation via asparagine GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex -- -- Cluster-8309.33507 BF_2 35.00 1.28 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33509 BF_2 248.00 7.22 1724 270005400 EFA01848.1 166 6.3e-09 hypothetical protein TcasGA2_TC007451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02234 Cyclin-dependent kinase inhibitor GO:0007050//GO:0045859 cell cycle arrest//regulation of protein kinase activity GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity GO:0005634 nucleus -- -- Cluster-8309.33510 BF_2 3274.88 75.74 2096 642928891 XP_008195605.1 745 5.6e-76 PREDICTED: coatomer subunit zeta-1 [Tribolium castaneum] 346709586 AK384066.1 60 4.18285e-20 Bombyx mori mRNA, clone: fcaL06G10 -- -- -- -- P61923 549 1.2e-54 Coatomer subunit zeta-1 OS=Homo sapiens GN=COPZ1 PE=1 SV=1 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG3343 Vesicle coat complex COPI, zeta subunit Cluster-8309.33512 BF_2 126.23 1.01 5525 546686097 ERL95494.1 1149 2.1e-122 hypothetical protein D910_12756 [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.37678e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 654 2.2e-66 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF06743//PF05733 FAST kinase-like protein, subdomain 1//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0003723//GO:0004672 RNA binding//protein kinase activity GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.33513 BF_2 749.43 106.31 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33514 BF_2 77.61 0.83 4196 478257812 ENN77955.1 359 6.4e-31 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01155//PF04135 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Nucleolar RNA-binding protein, Nop10p family GO:0006464//GO:0001522//GO:0042254 cellular protein modification process//pseudouridine synthesis//ribosome biogenesis GO:0030515//GO:0016151 snoRNA binding//nickel cation binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.33515 BF_2 647.41 5.00 5700 478263085 ENN81485.1 1571 2.5e-171 hypothetical protein YQE_02177, partial [Dendroctonus ponderosae] -- -- -- -- -- K03509 POLH DNA polymerase eta http://www.genome.jp/dbget-bin/www_bget?ko:K03509 Q9Y253 864 9.9e-91 DNA polymerase eta OS=Homo sapiens GN=POLH PE=1 SV=1 PF11799//PF00096//PF00817 impB/mucB/samB family C-terminal domain//Zinc finger, C2H2 type//impB/mucB/samB family GO:0006281 DNA repair GO:0003684//GO:0046872 damaged DNA binding//metal ion binding -- -- KOG2095 DNA polymerase iota/DNA damage inducible protein Cluster-8309.33517 BF_2 50.65 0.63 3629 642933004 XP_008197224.1 752 1.5e-76 PREDICTED: uncharacterized protein LOC658601 [Tribolium castaneum]>gi|270011458|gb|EFA07906.1| hypothetical protein TcasGA2_TC005481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 362 1.0e-32 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 PF00858//PF04610 Amiloride-sensitive sodium channel//TrbL/VirB6 plasmid conjugal transfer protein GO:0030255//GO:0006814//GO:0006810 protein secretion by the type IV secretion system//sodium ion transport//transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.33521 BF_2 44.85 1.61 1449 189234413 XP_975276.2 676 3.9e-68 PREDICTED: uncharacterized protein LOC664170 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33522 BF_2 854.54 10.82 3590 642913459 XP_008201021.1 968 1.3e-101 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] -- -- -- -- -- K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q99K85 573 3.5e-57 Phosphoserine aminotransferase OS=Mus musculus GN=Psat1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.33523 BF_2 3.00 0.49 542 642912447 XP_008200864.1 189 4.3e-12 PREDICTED: LOW QUALITY PROTEIN: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33524 BF_2 9.00 1.21 597 241647358 XP_002411125.1 736 1.7e-75 ribosomal protein L18A, putative [Ixodes scapularis]>gi|215503755|gb|EEC13249.1| ribosomal protein L18A, putative [Ixodes scapularis] -- -- -- -- -- K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q7ZWJ4 651 5.2e-67 60S ribosomal protein L18a OS=Danio rerio GN=rpl18a PE=2 SV=1 PF01775 Ribosomal L18ae/LX protein domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.33525 BF_2 36.00 0.38 4220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08152 GUCT (NUC152) domain -- -- GO:0003723//GO:0004386//GO:0005524 RNA binding//helicase activity//ATP binding GO:0005634 nucleus -- -- Cluster-8309.33526 BF_2 992.00 7.58 5761 642923580 XP_008193569.1 3308 0.0e+00 PREDICTED: ankyrin-3 [Tribolium castaneum]>gi|642923582|ref|XP_008193570.1| PREDICTED: ankyrin-3 [Tribolium castaneum]>gi|270007684|gb|EFA04132.1| hypothetical protein TcasGA2_TC014376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12955 235 8.7e-18 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF07525//PF16320//PF00023//PF13606//PF17076 SOCS box//Ribosomal protein L7/L12 dimerisation domain//Ankyrin repeat//Ankyrin repeat//SBE2, cell-qall formation GO:0006412//GO:0035556//GO:0042254//GO:0031505 translation//intracellular signal transduction//ribosome biogenesis//fungal-type cell wall organization GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG4177 Ankyrin Cluster-8309.33529 BF_2 121.00 11.23 738 91087993 XP_973641.1 512 2.0e-49 PREDICTED: protein aveugle [Tribolium castaneum]>gi|270011900|gb|EFA08348.1| hypothetical protein TcasGA2_TC005991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8ML92 316 4.5e-28 Protein aveugle OS=Drosophila melanogaster GN=ave PE=1 SV=1 PF07647//PF00536//PF02198 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.33530 BF_2 7359.94 26.74 11801 478257615 ENN77767.1 2921 0.0e+00 hypothetical protein YQE_05739, partial [Dendroctonus ponderosae]>gi|546673589|gb|ERL85158.1| hypothetical protein D910_02580 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VI25 2070 2.9e-230 Neurochondrin homolog OS=Drosophila melanogaster GN=Neurochondrin PE=2 SV=1 PF02028//PF00240//PF03810//PF01383//PF14560//PF03840//PF01728 BCCT, betaine/carnitine/choline family transporter//Ubiquitin family//Importin-beta N-terminal domain//CpcD/allophycocyanin linker domain//Ubiquitin-like domain//Preprotein translocase SecG subunit//FtsJ-like methyltransferase GO:0009306//GO:0006886//GO:0006810//GO:0032259//GO:0015031 protein secretion//intracellular protein transport//transport//methylation//protein transport GO:0005215//GO:0008536//GO:0005515//GO:0015450//GO:0008168 transporter activity//Ran GTPase binding//protein binding//P-P-bond-hydrolysis-driven protein transmembrane transporter activity//methyltransferase activity GO:0016021//GO:0009941//GO:0030089//GO:0016020 integral component of membrane//chloroplast envelope//phycobilisome//membrane KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ Cluster-8309.33531 BF_2 152.91 1.08 6191 478251874 ENN72313.1 897 3.9e-93 hypothetical protein YQE_11056, partial [Dendroctonus ponderosae] -- -- -- -- -- K13337 PEX19 peroxin-19 http://www.genome.jp/dbget-bin/www_bget?ko:K13337 Q9VJZ7 458 1.3e-43 Ribosomal RNA processing protein 1 homolog OS=Drosophila melanogaster GN=Nnp-1 PE=1 SV=1 PF00435//PF01347//PF05997//PF04614//PF02865 Spectrin repeat//Lipoprotein amino terminal region//Nucleolar protein,Nop52//Pex19 protein family//STAT protein, protein interaction domain GO:0006364//GO:0006355//GO:0006869//GO:0007165 rRNA processing//regulation of transcription, DNA-templated//lipid transport//signal transduction GO:0003700//GO:0004871//GO:0005515//GO:0005319 transcription factor activity, sequence-specific DNA binding//signal transducer activity//protein binding//lipid transporter activity GO:0005777//GO:0005667//GO:0030688 peroxisome//transcription factor complex//preribosome, small subunit precursor KOG3911 Nucleolar protein NOP52/RRP1 Cluster-8309.33532 BF_2 14.00 1.90 596 -- -- -- -- -- 58197573 AC154128.3 58 1.47591e-19 Tribolium castaneum BAC T.cast_C36A24 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33533 BF_2 1388.00 248.19 521 91084415 XP_967749.1 497 7.9e-48 PREDICTED: macrophage migration inhibitory factor homolog [Tribolium castaneum]>gi|270008846|gb|EFA05294.1| hypothetical protein TcasGA2_TC015451 [Tribolium castaneum] -- -- -- -- -- K07253 MIF phenylpyruvate tautomerase http://www.genome.jp/dbget-bin/www_bget?ko:K07253 P91850 244 7.1e-20 Macrophage migration inhibitory factor homolog OS=Brugia malayi GN=Bm1_28435 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1759 Macrophage migration inhibitory factor Cluster-8309.33535 BF_2 61.20 5.62 743 642931962 XP_008196796.1 425 2.5e-39 PREDICTED: glutaredoxin-C4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q8LFQ6 275 2.6e-23 Glutaredoxin-C4 OS=Arabidopsis thaliana GN=GRXC4 PE=2 SV=2 PF01323//PF00462//PF00085 DSBA-like thioredoxin domain//Glutaredoxin//Thioredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035 electron carrier activity//protein disulfide oxidoreductase activity -- -- KOG1752 Glutaredoxin and related proteins Cluster-8309.33536 BF_2 77.47 4.90 949 478250587 ENN71079.1 476 3.9e-45 hypothetical protein YQE_12013, partial [Dendroctonus ponderosae]>gi|546672941|gb|ERL84649.1| hypothetical protein D910_02077 [Dendroctonus ponderosae] -- -- -- -- -- K03676 grxC, GLRX, GLRX2 glutaredoxin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03676 Q8LFQ6 277 1.9e-23 Glutaredoxin-C4 OS=Arabidopsis thaliana GN=GRXC4 PE=2 SV=2 PF01323//PF00462//PF00085 DSBA-like thioredoxin domain//Glutaredoxin//Thioredoxin GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG1752 Glutaredoxin and related proteins Cluster-8309.33538 BF_2 170.00 5.64 1548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33539 BF_2 80.64 1.25 2981 642919702 XP_008192028.1 2010 1.6e-222 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 900 3.5e-95 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.33540 BF_2 61.43 1.24 2364 329762924 AEC04843.1 228 5.6e-16 chemosensory protein [Batocera horsfieldi] 329762923 HQ587041.1 191 7.11321e-93 Batocera horsfieldi chemosensory protein (CSP2) mRNA, complete cds -- -- -- -- Q9W1C9 178 1.4e-11 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.33541 BF_2 883.00 56.15 945 332376134 AEE63207.1 824 1.7e-85 unknown [Dendroctonus ponderosae] 665816885 XM_008558965.1 93 8.3647e-39 PREDICTED: Microplitis demolitor ADP-ribosylation factor 1 (LOC103578032), mRNA K07939 ARF4 ADP-ribosylation factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K07939 P51644 765 4.9e-80 ADP-ribosylation factor 4 OS=Xenopus laevis GN=arf4 PE=1 SV=2 PF00025//PF04670//PF00071//PF00503//PF01591//PF01926//PF08477 ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//6-phosphofructo-2-kinase//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0007186//GO:0006013//GO:0007264//GO:0006000 signal transduction//G-protein coupled receptor signaling pathway//mannose metabolic process//small GTPase mediated signal transduction//fructose metabolic process GO:0005524//GO:0031683//GO:0003873//GO:0003924//GO:0005525//GO:0019001//GO:0004871 ATP binding//G-protein beta/gamma-subunit complex binding//6-phosphofructo-2-kinase activity//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.33542 BF_2 99.05 1.07 4144 642911681 XP_008200699.1 3110 0.0e+00 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1160 3.4e-125 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF01852//PF07647//PF00620//PF03121 START domain//SAM domain (Sterile alpha motif)//RhoGAP domain//Herpesviridae UL52/UL70 DNA primase GO:0006260//GO:0006269//GO:0006351//GO:0007165 DNA replication//DNA replication, synthesis of RNA primer//transcription, DNA-templated//signal transduction GO:0003896//GO:0008289//GO:0005515 DNA primase activity//lipid binding//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.33543 BF_2 347.84 4.52 3503 558201797 XP_006131692.1 250 2.3e-18 PREDICTED: zinc finger protein 135-like, partial [Pelodiscus sinensis] 667677333 AE014297.3 36 1.54433e-06 Drosophila melanogaster chromosome 3R K09208 KLF9S, BTEB krueppel-like factor 9/13/14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K09208 Q9Y2Y9 455 1.6e-43 Krueppel-like factor 13 OS=Homo sapiens GN=KLF13 PE=1 SV=1 PF13912//PF13465//PF02176//PF00096 C2H2-type zinc finger//Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.33544 BF_2 26.32 0.35 3466 91079768 XP_966889.1 792 3.3e-81 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 385 2.1e-35 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF01370//PF00106//PF01073 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0008152//GO:0008210 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//metabolic process//estrogen metabolic process GO:0016616//GO:0016491//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.33547 BF_2 297.23 14.21 1162 642938589 XP_008199854.1 397 7.0e-36 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X3 [Tribolium castaneum] 642938588 XM_008201632.1 200 3.41781e-98 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0005388 calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum -- -- Cluster-8309.33548 BF_2 11432.37 430.14 1399 642912129 XP_966308.2 889 7.5e-93 PREDICTED: peptidyl-prolyl cis-trans isomerase [Tribolium castaneum] 755876427 XM_005183940.2 169 7.07038e-81 PREDICTED: Musca domestica peptidyl-prolyl cis-trans isomerase (LOC101898665), mRNA K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P54985 780 1.3e-81 Peptidyl-prolyl cis-trans isomerase OS=Blattella germanica GN=CYPA PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.33549 BF_2 23.67 0.64 1840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33550 BF_2 382.00 22.61 994 189234428 XP_001816488.1 642 2.3e-64 PREDICTED: coatomer subunit beta [Tribolium castaneum]>gi|270001762|gb|EEZ98209.1| hypothetical protein TcasGA2_TC000641 [Tribolium castaneum] -- -- -- -- -- K17301 COPB1, SEC26 coatomer, subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17301 Q5ZIA5 545 1.7e-54 Coatomer subunit beta OS=Gallus gallus GN=COPB1 PE=2 SV=1 PF01602 Adaptin N terminal region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198 structural molecule activity GO:0030126//GO:0030117 COPI vesicle coat//membrane coat KOG1058 Vesicle coat complex COPI, beta subunit Cluster-8309.33551 BF_2 2563.99 47.17 2561 189234428 XP_001816488.1 3625 0.0e+00 PREDICTED: coatomer subunit beta [Tribolium castaneum]>gi|270001762|gb|EEZ98209.1| hypothetical protein TcasGA2_TC000641 [Tribolium castaneum] 821408518 XM_004279158.2 125 3.77161e-56 PREDICTED: Orcinus orca coatomer protein complex, subunit beta 1 (COPB1), mRNA K17301 COPB1, SEC26 coatomer, subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17301 P45437 2916 0.0e+00 Coatomer subunit beta OS=Drosophila melanogaster GN=betaCop PE=2 SV=2 PF02985//PF01602//PF07718//PF00514 HEAT repeat//Adaptin N terminal region//Coatomer beta C-terminal region//Armadillo/beta-catenin-like repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG1058 Vesicle coat complex COPI, beta subunit Cluster-8309.33552 BF_2 79.07 0.87 4101 642931115 XP_008201667.1 421 4.1e-38 PREDICTED: autism susceptibility gene 2 protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08597//PF06459//PF04617 Translation initiation factor eIF3 subunit//Ryanodine Receptor TM 4-6//Hox9 activation region GO:0006446//GO:0006816//GO:0006351//GO:0006874 regulation of translational initiation//calcium ion transport//transcription, DNA-templated//cellular calcium ion homeostasis GO:0005219//GO:0003743 ryanodine-sensitive calcium-release channel activity//translation initiation factor activity GO:0016021//GO:0005634//GO:0005737//GO:0005852//GO:0005622//GO:0005840 integral component of membrane//nucleus//cytoplasm//eukaryotic translation initiation factor 3 complex//intracellular//ribosome -- -- Cluster-8309.33553 BF_2 43.52 0.84 2444 91077452 XP_967401.1 1566 4.1e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.3e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF13676//PF01370//PF00106 TIR domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152//GO:0007165//GO:0055114 metabolic process//signal transduction//oxidation-reduction process GO:0003824//GO:0050662//GO:0005515//GO:0016491//GO:0000166 catalytic activity//coenzyme binding//protein binding//oxidoreductase activity//nucleotide binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.33555 BF_2 13.35 0.35 1880 546673917 ERL85431.1 763 4.1e-78 hypothetical protein D910_02851 [Dendroctonus ponderosae] -- -- -- -- -- K01103 PFKFB3 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3  http://www.genome.jp/dbget-bin/www_bget?ko:K01103 Q16875 241 5.7e-19 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 OS=Homo sapiens GN=PFKFB3 PE=1 SV=1 PF01591 6-phosphofructo-2-kinase GO:0006000//GO:0006013 fructose metabolic process//mannose metabolic process GO:0005524//GO:0003873 ATP binding//6-phosphofructo-2-kinase activity -- -- KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.3356 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33561 BF_2 1192.44 75.14 951 150416593 ABF60889.2 161 1.3e-08 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07941 Potassium channel Kv1.4 tandem inactivation domain GO:0006813 potassium ion transport GO:0005249//GO:0030955 voltage-gated potassium channel activity//potassium ion binding GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane -- -- Cluster-8309.33562 BF_2 16.83 0.34 2339 91087837 XP_967757.1 988 4.1e-104 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 691 4.7e-71 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF06756//PF01370//PF01118//PF01073 Chorion protein S19 C-terminal//NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0007275//GO:0008210//GO:0008207//GO:0055114//GO:0006694//GO:0008209 multicellular organismal development//estrogen metabolic process//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0051287//GO:0016616//GO:0016620 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042600 chorion -- -- Cluster-8309.33563 BF_2 1252.17 37.02 1702 91087837 XP_967757.1 1441 8.9e-157 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 783 7.3e-82 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF06756//PF01118//PF01073//PF01370 Male sterility protein//Chorion protein S19 C-terminal//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0007275//GO:0008207//GO:0006694//GO:0055114//GO:0008209 estrogen metabolic process//multicellular organismal development//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0003824//GO:0050662//GO:0051287//GO:0016616//GO:0080019//GO:0016620 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0042600 chorion -- -- Cluster-8309.33564 BF_2 25.09 0.33 3489 91078972 XP_974414.1 2195 6.8e-244 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1344 1.3e-146 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.33565 BF_2 3149.85 28.80 4863 546683392 ERL93211.1 2662 6.7e-298 hypothetical protein D910_10507, partial [Dendroctonus ponderosae] 795040839 XM_012011345.1 78 9.65586e-30 PREDICTED: Vollenhovia emeryi integrin beta-PS (LOC105561398), transcript variant X2, mRNA K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 2143 4.2e-239 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 PF03325//PF01437 Herpesvirus polymerase accessory protein//Plexin repeat GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0030337 DNA polymerase processivity factor activity GO:0042575//GO:0016020 DNA polymerase complex//membrane KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.33566 BF_2 79.01 0.88 4039 91078836 XP_971451.1 1905 3.3e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 2.13387e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.6e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0008152//GO:0006508//GO:0005975 metabolic process//proteolysis//carbohydrate metabolic process GO:0016787//GO:0004560//GO:0034701//GO:0008237//GO:0016805 hydrolase activity//alpha-L-fucosidase activity//tripeptidase activity//metallopeptidase activity//dipeptidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.33567 BF_2 18.19 0.53 1711 646710939 KDR16317.1 278 6.5e-22 Eukaryotic translation initiation factor 3 subunit G [Zootermopsis nevadensis] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q9VDM6 248 8.0e-20 Eukaryotic translation initiation factor 3 subunit G-2 OS=Drosophila melanogaster GN=eIF3-S4-2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.33571 BF_2 1405.78 33.40 2048 189238048 XP_001811309.1 1728 5.6e-190 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 1.4e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF01370//PF01073//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0003854//GO:0050662//GO:0003824//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.33572 BF_2 1.00 2.11 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33573 BF_2 1.00 0.73 338 -- -- -- -- -- 642934619 XM_970761.2 108 1.28503e-47 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33574 BF_2 2033.00 47.23 2088 282165699 NP_001107796.2 2156 1.3e-239 Sterol carrier protein X-related thiolase [Tribolium castaneum]>gi|270015166|gb|EFA11614.1| sterol carrier protein x [Tribolium castaneum] 666417103 LL712009.1 38 7.07158e-08 Elaeophora elaphi genome assembly E_elaphi ,scaffold EEL_contig0000408 K08764 SCP2, SCPX sterol carrier protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08764 O62742 1615 3.0e-178 Non-specific lipid-transfer protein OS=Oryctolagus cuniculus GN=SCP2 PE=1 SV=1 PF08545//PF00108//PF02803 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0006633//GO:0008152//GO:0042967 fatty acid biosynthetic process//metabolic process//acyl-carrier-protein biosynthetic process GO:0032934//GO:0004315//GO:0016747 sterol binding//3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1406 Peroxisomal 3-ketoacyl-CoA-thiolase P-44/SCP2 Cluster-8309.33576 BF_2 59.67 0.73 3720 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 7.2e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00989//PF00072//PF05504//PF00233//PF09771 PAS fold//Response regulator receiver domain//Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188 GO:0007165//GO:0000160//GO:0035307//GO:0006144//GO:0009847//GO:0006355 signal transduction//phosphorelay signal transduction system//positive regulation of protein dephosphorylation//purine nucleobase metabolic process//spore germination//regulation of transcription, DNA-templated GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0016020//GO:0071595 membrane//Nem1-Spo7 phosphatase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.33578 BF_2 224.52 12.99 1010 642922332 XP_008193116.1 1025 9.1e-109 PREDICTED: prickle-like protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43900 436 7.5e-42 Prickle-like protein 3 OS=Homo sapiens GN=PRICKLE3 PE=1 SV=2 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.33579 BF_2 3350.53 38.60 3918 91088343 XP_971105.1 967 1.9e-101 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] 755959155 XM_011306001.1 66 3.63858e-23 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 670 2.1e-68 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF02737//PF11857//PF01370//PF01781//PF02826//PF02882//PF12242 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Domain of unknown function (DUF3377)//NAD dependent epimerase/dehydratase family//Ribosomal L38e protein family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0006412//GO:0008152//GO:0006633//GO:0018874//GO:0006552//GO:0006631//GO:0046487//GO:0009396//GO:0006574//GO:0006550//GO:0055114//GO:0042254//GO:0006554//GO:0006568 translation//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//valine catabolic process//isoleucine catabolic process//oxidation-reduction process//ribosome biogenesis//lysine catabolic process//tryptophan metabolic process GO:0051287//GO:0016491//GO:0003824//GO:0004488//GO:0004222//GO:0050662//GO:0003735//GO:0000166//GO:0003857 NAD binding//oxidoreductase activity//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//metalloendopeptidase activity//coenzyme binding//structural constituent of ribosome//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.33580 BF_2 200.04 4.08 2337 91078348 XP_973652.1 1386 2.9e-150 PREDICTED: prostaglandin E synthase 2 [Tribolium castaneum]>gi|270003893|gb|EFA00341.1| hypothetical protein TcasGA2_TC003180 [Tribolium castaneum] -- -- -- -- -- K05309 PTGES2 microsomal prostaglandin-E synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05309 Q9N0A4 674 4.4e-69 Prostaglandin E synthase 2 OS=Macaca fascicularis GN=PTGES2 PE=1 SV=1 PF02798//PF00462//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG3029 Glutathione S-transferase-related protein Cluster-8309.33581 BF_2 356.56 5.02 3258 91077232 XP_968256.1 2161 5.5e-240 PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|642913746|ref|XP_008201143.1| PREDICTED: fizzy-related protein homolog [Tribolium castaneum]>gi|270002085|gb|EEZ98532.1| hypothetical protein TcasGA2_TC001036 [Tribolium castaneum] 780675948 XM_011698114.1 402 0 PREDICTED: Wasmannia auropunctata fizzy-related protein homolog (LOC105455066), mRNA K03364 CDH1 cell division cycle 20-like protein 1, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03364 Q9R1K5 1593 1.7e-175 Fizzy-related protein homolog OS=Mus musculus GN=Fzr1 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.33582 BF_2 333.07 5.02 3061 332373526 AEE61904.1 1352 3.3e-146 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 704 1.9e-72 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF00106//PF03435//PF01370 short chain dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG2733 Uncharacterized membrane protein Cluster-8309.33583 BF_2 449.94 2.03 9555 332373526 AEE61904.1 1287 3.6e-138 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 654 3.7e-66 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF01728//PF07941//PF01370//PF03435//PF00089//PF01073//PF00106//PF05706 FtsJ-like methyltransferase//Potassium channel Kv1.4 tandem inactivation domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Trypsin//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006508//GO:0032259//GO:0008152//GO:0008210//GO:0006813//GO:0006470//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0006570 proteolysis//methylation//metabolic process//estrogen metabolic process//potassium ion transport//protein dephosphorylation//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//tyrosine metabolic process GO:0004721//GO:0030955//GO:0003824//GO:0004725//GO:0016491//GO:0008168//GO:0005249//GO:0004252//GO:0003854//GO:0050662//GO:0016616 phosphoprotein phosphatase activity//potassium ion binding//catalytic activity//protein tyrosine phosphatase activity//oxidoreductase activity//methyltransferase activity//voltage-gated potassium channel activity//serine-type endopeptidase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0008076//GO:0016021 voltage-gated potassium channel complex//integral component of membrane KOG2733 Uncharacterized membrane protein Cluster-8309.33584 BF_2 434.51 3.98 4849 478263554 ENN81890.1 1552 3.4e-169 hypothetical protein YQE_01728, partial [Dendroctonus ponderosae] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9XZ43 1076 2.2e-115 Protein 5NUC OS=Lutzomyia longipalpis GN=5NUC PE=1 SV=1 PF03615//PF02872//PF00149 GCM motif protein//5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase GO:0006355//GO:0009166 regulation of transcription, DNA-templated//nucleotide catabolic process GO:0003677//GO:0016787 DNA binding//hydrolase activity -- -- -- -- Cluster-8309.33585 BF_2 27.31 0.79 1741 91086225 XP_972341.1 2192 7.5e-244 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 766937068 XM_011502671.1 253 1.78347e-127 PREDICTED: Ceratosolen solmsi marchali dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (LOC105364681), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 1784 6.3e-198 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016020 oligosaccharyltransferase complex//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.33586 BF_2 2668.03 47.44 2640 91086225 XP_972341.1 3634 0.0e+00 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 766937068 XM_011502671.1 253 2.72329e-127 PREDICTED: Ceratosolen solmsi marchali dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (LOC105364681), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 2940 0.0e+00 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016020//GO:0008250 membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.33587 BF_2 259.99 10.23 1350 642917784 XP_008191285.1 1610 1.8e-176 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X2 [Tribolium castaneum] 170065886 XM_001868022.1 344 3.56115e-178 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 1558 7.9e-172 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.33591 BF_2 18.50 1.10 991 642932529 XP_008197152.1 340 2.4e-29 PREDICTED: type-1 angiotensin II receptor-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33592 BF_2 4.00 1.70 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33594 BF_2 88.00 7.89 754 642938165 XP_008190990.1 225 4.0e-16 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.33595 BF_2 10.58 0.31 1717 189235434 XP_001813433.1 1605 8.7e-176 PREDICTED: paraplegin [Tribolium castaneum]>gi|270004289|gb|EFA00737.1| hypothetical protein TcasGA2_TC003619 [Tribolium castaneum] 242019804 XM_002430304.1 38 5.79366e-08 Pediculus humanus corporis conserved hypothetical protein, mRNA K09552 SPG7 spastic paraplegia 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09552 Q9UQ90 1125 1.6e-121 Paraplegin OS=Homo sapiens GN=SPG7 PE=1 SV=2 PF01434//PF00004 Peptidase family M41//ATPase family associated with various cellular activities (AAA) GO:0030163//GO:0006508 protein catabolic process//proteolysis GO:0017111//GO:0008270//GO:0005524//GO:0004222 nucleoside-triphosphatase activity//zinc ion binding//ATP binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.33596 BF_2 257.00 32.39 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33600 BF_2 215.00 20.87 718 91081077 XP_975460.1 633 1.9e-63 PREDICTED: UPF0587 protein CG4646 [Tribolium castaneum]>gi|642920128|ref|XP_008192218.1| PREDICTED: UPF0587 protein CG4646 [Tribolium castaneum]>gi|642920130|ref|XP_008192219.1| PREDICTED: UPF0587 protein CG4646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9A2 477 9.4e-47 UPF0587 protein CG4646 OS=Drosophila melanogaster GN=CG4646 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1296 Uncharacterized conserved protein Cluster-8309.33602 BF_2 251.64 4.13 2834 642925355 XP_008194516.1 3769 0.0e+00 PREDICTED: integrator complex subunit 2 [Tribolium castaneum]>gi|270008723|gb|EFA05171.1| hypothetical protein TcasGA2_TC015300 [Tribolium castaneum] 642925354 XM_008196294.1 497 0 PREDICTED: Tribolium castaneum integrator complex subunit 2 (LOC661595), mRNA K13139 INTS2 integrator complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13139 Q9H0H0 1934 4.2e-215 Integrator complex subunit 2 OS=Homo sapiens GN=INTS2 PE=1 SV=2 PF03391//PF14750//PF07527 Nepovirus coat protein, central domain//Integrator complex subunit 2//Hairy Orange GO:0016180//GO:0006355 snRNA processing//regulation of transcription, DNA-templated GO:0005198//GO:0003677 structural molecule activity//DNA binding GO:0019028//GO:0032039 viral capsid//integrator complex -- -- Cluster-8309.33604 BF_2 581.84 3.29 7682 546684532 ERL94163.1 2790 0.0e+00 hypothetical protein D910_11445 [Dendroctonus ponderosae] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1225 1.8e-132 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.33606 BF_2 211.91 3.58 2762 546686007 ERL95413.1 3162 0.0e+00 hypothetical protein D910_12677 [Dendroctonus ponderosae] 288872186 NM_001172404.1 254 7.92097e-128 Apis mellifera NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (Ndufs1), mRNA K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 Q94511 2538 3.7e-285 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 PF00384//PF00205//PF00211//PF10588//PF00111//PF09326 Molybdopterin oxidoreductase//Thiamine pyrophosphate enzyme, central domain//Adenylate and Guanylate cyclase catalytic domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//2Fe-2S iron-sulfur cluster binding domain//NADH-ubiquinone oxidoreductase subunit G, C-terminal GO:0009190//GO:0055114//GO:0035556//GO:0006118 cyclic nucleotide biosynthetic process//oxidation-reduction process//intracellular signal transduction//obsolete electron transport GO:0030976//GO:0000287//GO:0016849//GO:0051536//GO:0009055//GO:0016491//GO:0016651 thiamine pyrophosphate binding//magnesium ion binding//phosphorus-oxygen lyase activity//iron-sulfur cluster binding//electron carrier activity//oxidoreductase activity//oxidoreductase activity, acting on NAD(P)H -- -- KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-8309.33610 BF_2 934.17 22.78 2003 642923805 XP_008193890.1 1839 7.4e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 3.9e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.33611 BF_2 114.90 2.21 2462 642927244 XP_974103.2 1078 1.6e-114 PREDICTED: stromal membrane-associated protein 1-like [Tribolium castaneum] -- -- -- -- -- K12486 SMAP stromal membrane-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K12486 Q5EA00 525 8.7e-52 Stromal membrane-associated protein 2 OS=Bos taurus GN=SMAP2 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.33612 BF_2 53.64 0.40 5865 752891325 XP_011263696.1 1451 2.1e-157 PREDICTED: uncharacterized protein LOC105255869 [Camponotus floridanus] 752891324 XM_011265394.1 390 0 PREDICTED: Camponotus floridanus uncharacterized LOC105255869 (LOC105255869), mRNA -- -- -- -- -- -- -- -- PF07927 HicA toxin of bacterial toxin-antitoxin, -- -- GO:0003729 mRNA binding -- -- -- -- Cluster-8309.33613 BF_2 32.00 4.43 589 501291907 BAN20426.1 620 4.9e-62 ribosomal protein L17 [Riptortus pedestris] -- -- -- -- -- K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 A8CAG3 592 3.5e-60 60S ribosomal protein L17 OS=Phlebotomus papatasi GN=RpL17 PE=2 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-8309.33614 BF_2 3355.33 162.67 1150 270012376 EFA08824.1 491 8.7e-47 hypothetical protein TcasGA2_TC006521 [Tribolium castaneum] 734646853 XM_010754281.1 52 6.34411e-16 PREDICTED: Larimichthys crocea cytochrome c oxidase subunit 6A, mitochondrial-like (LOC104937958), mRNA K02266 COX6A cytochrome c oxidase subunit 6a http://www.genome.jp/dbget-bin/www_bget?ko:K02266 P12074 286 2.1e-24 Cytochrome c oxidase subunit 6A1, mitochondrial OS=Homo sapiens GN=COX6A1 PE=1 SV=4 PF02046 Cytochrome c oxidase subunit VIa GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0005751//GO:0045277 mitochondrial inner membrane//mitochondrial respiratory chain complex IV//respiratory chain complex IV KOG3469 Cytochrome c oxidase, subunit VIa/COX13 Cluster-8309.33615 BF_2 79.04 2.10 1861 91090210 XP_967762.1 1389 1.0e-150 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 585 7.3e-59 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016740//GO:0016758 transferase activity//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.33616 BF_2 122.55 1.88 3011 478256359 ENN76549.1 1496 6.6e-163 hypothetical protein YQE_07000, partial [Dendroctonus ponderosae]>gi|546680788|gb|ERL90994.1| hypothetical protein D910_08336 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 274 1.4e-22 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33617 BF_2 2436.72 27.60 3980 91092324 XP_970273.1 2461 1.1e-274 PREDICTED: vacuolar protein sorting-associated protein 45 [Tribolium castaneum]>gi|270015700|gb|EFA12148.1| hypothetical protein TcasGA2_TC002297 [Tribolium castaneum] -- -- -- -- -- K12479 VPS45 vacuolar protein sorting-associated protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K12479 P97390 1725 1.0e-190 Vacuolar protein sorting-associated protein 45 OS=Mus musculus GN=Vps45 PE=1 SV=1 PF02840//PF01546//PF00995//PF15184 Prp18 domain//Peptidase family M20/M25/M40//Sec1 family//Mitochondrial import receptor subunit TOM6 homolog GO:0008152//GO:0006281//GO:0016192//GO:0008380//GO:0006904 metabolic process//DNA repair//vesicle-mediated transport//RNA splicing//vesicle docking involved in exocytosis GO:0003677//GO:0016787 DNA binding//hydrolase activity GO:0005681//GO:0005742 spliceosomal complex//mitochondrial outer membrane translocase complex KOG2276 Metalloexopeptidases Cluster-8309.33618 BF_2 4.00 0.39 712 391342263 XP_003745440.1 729 1.4e-74 PREDICTED: probable ATP-dependent RNA helicase DDX5-like [Metaseiulus occidentalis] 817196012 XM_012418150.1 70 3.80007e-26 PREDICTED: Orussus abietinus DEAD-box ATP-dependent RNA helicase 20-like (LOC105696021), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 615 9.2e-63 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.33619 BF_2 132.11 1.21 4842 642926741 XP_008194993.1 1564 1.4e-170 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X3 [Tribolium castaneum] 611988503 XM_007481079.1 71 7.48473e-26 PREDICTED: Monodelphis domestica dishevelled segment polarity protein 1 (DVL1), transcript variant X3, mRNA K02353 DVL segment polarity protein dishevelled http://www.genome.jp/dbget-bin/www_bget?ko:K02353 B1WAP7 960 6.2e-102 Segment polarity protein dishevelled homolog DVL-3 OS=Xenopus tropicalis GN=dvl3 PE=2 SV=1 PF00610//PF08001//PF00595//PF13180 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//CMV US//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0030683//GO:0035556 evasion or tolerance by virus of host immune response//intracellular signal transduction GO:0005515 protein binding GO:0044386 integral to host endoplasmic reticulum membrane KOG3571 Dishevelled 3 and related proteins Cluster-8309.33620 BF_2 18.00 1.24 896 149286910 ABR23354.1 1043 6.6e-111 40S ribosomal protein S2/30S [Ornithodoros parkeri] 769868691 XM_011648094.1 156 7.53238e-74 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S2-like (LOC105433023), mRNA K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P31009 971 6.1e-104 40S ribosomal protein S2 OS=Drosophila melanogaster GN=RpS2 PE=1 SV=2 PF00333//PF03719 Ribosomal protein S5, N-terminal domain//Ribosomal protein S5, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-8309.33623 BF_2 278.31 13.88 1126 642936556 XP_008198483.1 150 3.0e-07 PREDICTED: uncharacterized protein LOC103314366 [Tribolium castaneum]>gi|270014136|gb|EFA10584.1| hypothetical protein TcasGA2_TC012840 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.33625 BF_2 2996.28 40.21 3404 270003289 EEZ99736.1 3087 0.0e+00 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.12739e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00130//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.33626 BF_2 41.13 0.50 3727 642919579 XP_008191929.1 2790 0.0e+00 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q61316 1786 7.9e-198 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF04355//PF06723 SmpA / OmlA family//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005524 ATP binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.33630 BF_2 101.50 1.77 2689 478256386 ENN76576.1 571 1.1e-55 hypothetical protein YQE_07025, partial [Dendroctonus ponderosae]>gi|546680818|gb|ERL91024.1| hypothetical protein D910_08366 [Dendroctonus ponderosae] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q9VU70 394 1.5e-36 Tetratricopeptide repeat protein 36 homolog OS=Drosophila melanogaster GN=CG14105 PE=1 SV=1 PF13371//PF00515//PF13374//PF13414//PF05887//PF03839//PF13181//PF01414//PF05434 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Procyclic acidic repetitive protein (PARP)//Translocation protein Sec62//Tetratricopeptide repeat//Delta serrate ligand//TMEM9 GO:0015031//GO:0007154 protein transport//cell communication GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG2927 Membrane component of ER protein translocation complex Cluster-8309.33631 BF_2 24.16 0.35 3139 157126475 XP_001660898.1 773 4.7e-79 AAEL010538-PA [Aedes aegypti]>gi|108873249|gb|EAT37474.1| AAEL010538-PA [Aedes aegypti] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q99442 380 7.2e-35 Translocation protein SEC62 OS=Homo sapiens GN=SEC62 PE=1 SV=1 PF05132//PF05434//PF03169//PF03839//PF13181//PF13414//PF05887//PF00515//PF13374//PF13371 RNA polymerase III RPC4//TMEM9//OPT oligopeptide transporter protein//Translocation protein Sec62//Tetratricopeptide repeat//TPR repeat//Procyclic acidic repetitive protein (PARP)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006144//GO:0055085//GO:0006351//GO:0006383//GO:0015031//GO:0006206 purine nucleobase metabolic process//transmembrane transport//transcription, DNA-templated//transcription from RNA polymerase III promoter//protein transport//pyrimidine nucleobase metabolic process GO:0005515//GO:0003677//GO:0003899//GO:0008565 protein binding//DNA binding//DNA-directed RNA polymerase activity//protein transporter activity GO:0016021//GO:0005666//GO:0005730//GO:0016020 integral component of membrane//DNA-directed RNA polymerase III complex//nucleolus//membrane KOG2927 Membrane component of ER protein translocation complex Cluster-8309.33632 BF_2 3679.26 69.84 2491 157135017 XP_001656503.1 773 3.8e-79 AAEL013226-PA [Aedes aegypti]>gi|108870320|gb|EAT34545.1| AAEL013226-PA [Aedes aegypti] -- -- -- -- -- K12275 SEC62 translocation protein SEC62 http://www.genome.jp/dbget-bin/www_bget?ko:K12275 Q9VU70 394 1.4e-36 Tetratricopeptide repeat protein 36 homolog OS=Drosophila melanogaster GN=CG14105 PE=1 SV=1 PF05887//PF13414//PF00515//PF13374//PF13371//PF05434//PF03169//PF05132//PF13181//PF03839 Procyclic acidic repetitive protein (PARP)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TMEM9//OPT oligopeptide transporter protein//RNA polymerase III RPC4//Tetratricopeptide repeat//Translocation protein Sec62 GO:0006144//GO:0006383//GO:0006351//GO:0055085//GO:0015031//GO:0006206 purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//transmembrane transport//protein transport//pyrimidine nucleobase metabolic process GO:0005515//GO:0003899//GO:0003677//GO:0008565 protein binding//DNA-directed RNA polymerase activity//DNA binding//protein transporter activity GO:0016021//GO:0005730//GO:0005666//GO:0016020 integral component of membrane//nucleolus//DNA-directed RNA polymerase III complex//membrane KOG2927 Membrane component of ER protein translocation complex Cluster-8309.33633 BF_2 29.61 0.60 2350 478256696 ENN76878.1 1106 8.6e-118 hypothetical protein YQE_06719, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5E9V4 469 2.6e-45 Protein RRNAD1 OS=Bos taurus GN=RRNAD1 PE=2 SV=1 PF08123 Histone methylation protein DOT1 GO:0006479//GO:0006554 protein methylation//lysine catabolic process GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.33634 BF_2 244.00 7.88 1583 642928334 XP_008195539.1 388 1.0e-34 PREDICTED: lysozyme-like [Tribolium castaneum] -- -- -- -- -- K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 297 1.5e-25 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01874//PF00646 ATP:dephospho-CoA triphosphoribosyl transferase//F-box domain GO:0016310 phosphorylation GO:0046917//GO:0005515//GO:0005524 triphosphoribosyl-dephospho-CoA synthase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.33635 BF_2 354.92 14.73 1295 91083379 XP_967173.1 375 2.8e-33 PREDICTED: heat shock factor-binding protein 1 [Tribolium castaneum]>gi|270007782|gb|EFA04230.1| hypothetical protein TcasGA2_TC014481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDI2 225 2.8e-17 Heat shock factor-binding protein 1 OS=Pongo abelii GN=HSBP1 PE=3 SV=1 PF02865//PF04513//PF00103//PF06152//PF05478//PF06008 STAT protein, protein interaction domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Somatotropin hormone family//Phage minor capsid protein 2//Prominin//Laminin Domain I GO:0030334//GO:0007165//GO:0045995//GO:0030155//GO:0006355 regulation of cell migration//signal transduction//regulation of embryonic development//regulation of cell adhesion//regulation of transcription, DNA-templated GO:0005198//GO:0005179//GO:0003700//GO:0005102//GO:0004871 structural molecule activity//hormone activity//transcription factor activity, sequence-specific DNA binding//receptor binding//signal transducer activity GO:0019031//GO:0005667//GO:0016021//GO:0019028//GO:0005576 viral envelope//transcription factor complex//integral component of membrane//viral capsid//extracellular region KOG4117 Heat shock factor binding protein Cluster-8309.33637 BF_2 2627.52 26.97 4362 642921956 XP_008192959.1 3973 0.0e+00 PREDICTED: coatomer subunit beta' [Tribolium castaneum]>gi|270007308|gb|EFA03756.1| hypothetical protein TcasGA2_TC013867 [Tribolium castaneum] 820849966 XM_003694119.2 415 0 PREDICTED: Apis florea coatomer subunit beta' (LOC100872730), mRNA K17302 COPB2, SEC27 coatomer, subunit beta' http://www.genome.jp/dbget-bin/www_bget?ko:K17302 O62621 3297 0.0e+00 Coatomer subunit beta' OS=Drosophila melanogaster GN=beta'Cop PE=2 SV=2 PF13181//PF00400//PF04053 Tetratricopeptide repeat//WD domain, G-beta repeat//Coatomer WD associated region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0276 Vesicle coat complex COPI, beta' subunit Cluster-8309.33638 BF_2 657.89 2.17 12956 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 733 3.5e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF01607//PF00642//PF02198//PF01522//PF03176 Chitin binding Peritrophin-A domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Sterile alpha motif (SAM)/Pointed domain//Polysaccharide deacetylase//MMPL family GO:0006030//GO:0005975//GO:0006807 chitin metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0043565//GO:0046872//GO:0008061//GO:0016810 sequence-specific DNA binding//metal ion binding//chitin binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0005634//GO:0016020//GO:0005576 nucleus//membrane//extracellular region -- -- Cluster-8309.3364 BF_2 3.00 0.32 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33642 BF_2 27.00 0.51 2495 642921890 XP_008192932.1 1662 3.1e-182 PREDICTED: cardioacceleratory peptide receptor 2 isoform X1 [Tribolium castaneum]>gi|296396897|gb|ADH10240.1| CCAP receptor 2 [Tribolium castaneum] -- -- -- -- -- K08376 NPSR1, GPR154 neuropeptide S receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08376 Q868T3 1047 2.6e-112 Cardioacceleratory peptide receptor OS=Drosophila melanogaster GN=CCAP-R PE=2 SV=3 PF02118//PF00001 Srg family chemoreceptor//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0007165//GO:0007606 G-protein coupled receptor signaling pathway//signal transduction//sensory perception of chemical stimulus GO:0004888//GO:0004930 transmembrane signaling receptor activity//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.33645 BF_2 365.61 11.56 1610 91083251 XP_974045.1 485 6.0e-46 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 780659103 XM_011694063.1 107 2.38517e-46 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 436 1.2e-41 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF00270//PF02776 DEAD/DEAH box helicase//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain -- -- GO:0003676//GO:0005524//GO:0030976//GO:0008026 nucleic acid binding//ATP binding//thiamine pyrophosphate binding//ATP-dependent helicase activity -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.33646 BF_2 1299.85 33.71 1900 91083251 XP_974045.1 697 1.9e-70 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 442626186 NM_001273171.1 169 9.66735e-81 Drosophila melanogaster helicase at 25E (Hel25E), transcript variant D, mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q63413 618 1.1e-62 Spliceosome RNA helicase Ddx39b OS=Rattus norvegicus GN=Ddx39b PE=2 SV=3 PF00270//PF00765//PF00128//PF02391//PF04851 DEAD/DEAH box helicase//Autoinducer synthase//Alpha amylase, catalytic domain//MoaE protein//Type III restriction enzyme, res subunit GO:0006777//GO:0005975 Mo-molybdopterin cofactor biosynthetic process//carbohydrate metabolic process GO:0005524//GO:0003824//GO:0016740//GO:0016787//GO:0003677//GO:0008026//GO:0003676//GO:0043169 ATP binding//catalytic activity//transferase activity//hydrolase activity//DNA binding//ATP-dependent helicase activity//nucleic acid binding//cation binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.33648 BF_2 288.00 10.41 1445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33650 BF_2 26.70 0.67 1955 264667463 ACY71317.1 234 9.3e-17 ribosomal protein L22 [Chrysomela tremula] 751203339 XM_011176882.1 46 2.36185e-12 PREDICTED: Solenopsis invicta 60S ribosomal protein L22-like (LOC105207442), mRNA -- -- -- -- P50887 131 3.4e-06 60S ribosomal protein L22 OS=Drosophila melanogaster GN=RpL22 PE=1 SV=2 PF01776 Ribosomal L22e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.33651 BF_2 340.47 1.62 9071 642930846 XP_008196111.1 677 1.9e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33653 BF_2 47.52 1.93 1317 642937410 XP_008198824.1 862 9.5e-90 PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|642937412|ref|XP_008198826.1| PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|270000810|gb|EEZ97257.1| hypothetical protein TcasGA2_TC011057 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 380 3.0e-35 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152//GO:0008654//GO:0046486//GO:0042967 metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.33654 BF_2 1103.12 22.63 2326 91089723 XP_975024.1 1451 8.4e-158 PREDICTED: ATPase family AAA domain-containing protein 1-B [Tribolium castaneum]>gi|270011311|gb|EFA07759.1| hypothetical protein TcasGA2_TC005313 [Tribolium castaneum] 768421023 XM_011553001.1 182 7.04683e-88 PREDICTED: Plutella xylostella ATPase family AAA domain-containing protein 1-A (LOC105383005), mRNA -- -- -- -- Q503W7 1051 8.4e-113 ATPase family AAA domain-containing protein 1-B OS=Danio rerio GN=atad1b PE=2 SV=2 PF02562//PF02367//PF06414//PF00910//PF05496//PF00158//PF06068//PF01695//PF07728//PF07724//PF00004 PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//RNA helicase//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0002949//GO:0006310//GO:0006355//GO:0006281 tRNA threonylcarbamoyladenosine modification//DNA recombination//regulation of transcription, DNA-templated//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0016301//GO:0016887//GO:0008134//GO:0005524 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//kinase activity//ATPase activity//transcription factor binding//ATP binding GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0737 AAA+-type ATPase Cluster-8309.33655 BF_2 3034.05 52.15 2721 349584988 BAL03254.1 1164 1.9e-124 93 kDa serpin [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q5JJ64 501 5.9e-49 Uncharacterized serpin-like protein TK1782 OS=Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=TK1782 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.33656 BF_2 1008.54 12.27 3725 270014262 EFA10710.1 1560 3.1e-170 domino [Tribolium castaneum] 760445496 XM_011401515.1 99 1.56382e-41 Auxenochlorella protothecoides Helicase swr1 partial mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 667 4.5e-68 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF07088//PF01637//PF03796//PF00176//PF05625//PF00154//PF00004 GvpD gas vesicle protein//Archaeal ATPase//DnaB-like helicase C terminal domain//SNF2 family N-terminal domain//PAXNEB protein//recA bacterial DNA recombination protein//ATPase family associated with various cellular activities (AAA) GO:0006281//GO:0006260//GO:0009432 DNA repair//DNA replication//SOS response GO:0005524//GO:0003678//GO:0003697 ATP binding//DNA helicase activity//single-stranded DNA binding GO:0005657//GO:0033588 replication fork//Elongator holoenzyme complex KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.33658 BF_2 7.00 0.62 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.33659 BF_2 21.00 1.37 929 325303614 DAA34555.1 490 9.1e-47 TPA_exp: microtubule-binding protein [Amblyomma variegatum] -- -- -- -- -- -- -- -- -- M5B4R7 486 1.1e-47 Translationally-controlled tumor protein homolog OS=Grammostola rosea PE=2 SV=1 PF04048//PF15225//PF01649 Sec8 exocyst complex component specific domain//Interleukin 32//Ribosomal protein S20 GO:0006955//GO:0015031//GO:0042254//GO:0006412//GO:0006904 immune response//protein transport//ribosome biogenesis//translation//vesicle docking involved in exocytosis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0000145//GO:0005622//GO:0005840 exocyst//intracellular//ribosome KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.33660 BF_2 8.00 3.75 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33661 BF_2 26.17 0.84 1589 546680707 ERL90933.1 674 7.2e-68 hypothetical protein D910_08275 [Dendroctonus ponderosae] 27616447 BX043166.1 94 3.96597e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC15CD01 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K03521 fixA, etfB electron transfer flavoprotein beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03521 Q9DCW4 573 1.5e-57 Electron transfer flavoprotein subunit beta OS=Mus musculus GN=Etfb PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3180 Electron transfer flavoprotein, beta subunit Cluster-8309.33662 BF_2 702.61 8.74 3649 225543455 NP_001139378.1 1092 5.6e-116 daughters against dpp [Tribolium castaneum] -- -- -- -- -- K04677 SMAD6_7 mothers against decapentaplegic homolog 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04677 O43541 570 7.8e-57 Mothers against decapentaplegic homolog 6 OS=Homo sapiens GN=SMAD6 PE=1 SV=2 PF03165//PF04795//PF03166 MH1 domain//PAPA-1-like conserved region//MH2 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0031011//GO:0005622 Ino80 complex//intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.33665 BF_2 562.68 5.06 4942 642931127 XP_008201673.1 1322 1.6e-142 PREDICTED: uncharacterized protein LOC655872 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02734 DAK2 domain GO:0046486//GO:0006071 glycerolipid metabolic process//glycerol metabolic process GO:0004371 glycerone kinase activity -- -- -- -- Cluster-8309.33666 BF_2 528.00 4.66 5028 642919614 XP_008191940.1 948 3.9e-99 PREDICTED: serine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K14821 BUD20 bud site selection protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K14821 Q9W3Y0 403 2.5e-37 Zinc finger protein 593 homolog OS=Drosophila melanogaster GN=CG3224 PE=2 SV=1 PF00587//PF17122 tRNA synthetase class II core domain (G, H, P, S and T)//Zinc-finger GO:0006418 tRNA aminoacylation for protein translation GO:0005515//GO:0004812//GO:0008270//GO:0005524//GO:0000166 protein binding//aminoacyl-tRNA ligase activity//zinc ion binding//ATP binding//nucleotide binding -- -- KOG3408 U1-like Zn-finger-containing protein, probabl erole in RNA processing/splicing Cluster-8309.33669 BF_2 27.36 1.02 1408 478258160 ENN78298.1 1097 5.7e-117 hypothetical protein YQE_05448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZV5 799 8.4e-84 Cysteine and histidine-rich protein 1 homolog OS=Drosophila melanogaster GN=CG32486 PE=2 SV=2 PF00097//PF03145//PF02176 Zinc finger, C3HC4 type (RING finger)//Seven in absentia protein family//TRAF-type zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.33670 BF_2 9.57 1.12 646 167444204 ABZ80663.1 385 9.5e-35 hypothetical antimicrobial peptide [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.33671 BF_2 7111.00 2771.99 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33672 BF_2 1524.22 13.76 4920 91087491 XP_968373.1 1415 2.7e-153 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 9.97945e-15 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1078 1.3e-115 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF05699//PF02803//PF00108 hAT family C-terminal dimerisation region//Thiolase, C-terminal domain//Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747//GO:0046983 transferase activity, transferring acyl groups other than amino-acyl groups//protein dimerization activity -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.33673 BF_2 55.19 0.61 4095 91078908 XP_967303.1 587 2.3e-57 PREDICTED: U1 small nuclear ribonucleoprotein 70 kDa [Tribolium castaneum]>gi|270003669|gb|EFA00117.1| hypothetical protein TcasGA2_TC002933 [Tribolium castaneum] 766937927 XM_011503139.1 111 3.67226e-48 PREDICTED: Ceratosolen solmsi marchali U1 small nuclear ribonucleoprotein 70 kDa-like (LOC105365059), mRNA K11093 SNRP70 U1 small nuclear ribonucleoprotein 70kDa http://www.genome.jp/dbget-bin/www_bget?ko:K11093 P17133 503 5.2e-49 U1 small nuclear ribonucleoprotein 70 kDa OS=Drosophila melanogaster GN=snRNP-U1-70K PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:1901363//GO:0003676//GO:0097159 heterocyclic compound binding//nucleic acid binding//organic cyclic compound binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.33675 BF_2 2551.87 88.53 1493 332376979 AEE63629.1 1831 4.7e-202 unknown [Dendroctonus ponderosae]>gi|478249843|gb|ENN70350.1| hypothetical protein YQE_12858, partial [Dendroctonus ponderosae]>gi|546674164|gb|ERL85616.1| hypothetical protein D910_03035 [Dendroctonus ponderosae] 158296763 XM_317113.3 386 0 Anopheles gambiae str. PEST AGAP008345-PA (AgaP_AGAP008345) mRNA, complete cds K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q3ZC89 1528 2.6e-168 Methionine aminopeptidase 2 OS=Bos taurus GN=METAP2 PE=2 SV=1 PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- KOG2775 Metallopeptidase Cluster-8309.33676 BF_2 567.14 19.64 1495 478250728 ENN71220.1 832 3.2e-86 hypothetical protein YQE_12148, partial [Dendroctonus ponderosae]>gi|546678591|gb|ERL89173.1| hypothetical protein D910_06548 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4LFQ9 737 1.4e-76 Protein alan shepard OS=Drosophila virilis GN=shep PE=3 SV=2 PF09726//PF00076 Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG4733 FOG: RRM domain Cluster-8309.33680 BF_2 1768.91 10.79 7148 332375668 AEE62975.1 2213 1.1e-245 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1522 6.2e-167 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF07724//PF00437//PF00004//PF00158//PF06068//PF01057//PF05496//PF07728//PF01695//PF14532//PF10662//PF00270//PF02367//PF02562//PF00005 AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Ethanolamine utilisation - propanediol utilisation//DEAD/DEAH box helicase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ABC transporter GO:0006576//GO:0006310//GO:0002949//GO:0019079//GO:0006281//GO:0006810//GO:0006355 cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification//viral genome replication//DNA repair//transport//regulation of transcription, DNA-templated GO:0003678//GO:0003676//GO:0009378//GO:0005524//GO:0008134//GO:0016887 DNA helicase activity//nucleic acid binding//four-way junction helicase activity//ATP binding//transcription factor binding//ATPase activity GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.33681 BF_2 630.54 5.09 5471 642934848 XP_008197836.1 2731 7.5e-306 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.67958e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA K10423 CLIP3_4 CAP-Gly domain-containing linker protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10423 Q5JR59 254 5.2e-20 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33682 BF_2 90.43 1.72 2488 332374040 AEE62161.1 1406 1.5e-152 unknown [Dendroctonus ponderosae]>gi|478259932|gb|ENN79734.1| hypothetical protein YQE_03790, partial [Dendroctonus ponderosae]>gi|546674727|gb|ERL86036.1| hypothetical protein D910_03450 [Dendroctonus ponderosae] -- -- -- -- -- K00965 galT, GALT UDPglucose--hexose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00965 Q9VMA2 1039 2.2e-111 Probable galactose-1-phosphate uridylyltransferase OS=Drosophila melanogaster GN=Galt PE=2 SV=2 PF01087//PF02744//PF07074 Galactose-1-phosphate uridyl transferase, N-terminal domain//Galactose-1-phosphate uridyl transferase, C-terminal domain//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006012//GO:0006613//GO:0009117 galactose metabolic process//cotranslational protein targeting to membrane//nucleotide metabolic process GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG2958 Galactose-1-phosphate uridylyltransferase Cluster-8309.33683 BF_2 1381.00 15.68 3971 91086963 XP_973116.1 884 8.1e-92 PREDICTED: protein SOX-15-like isoform X1 [Tribolium castaneum] 642929295 XM_008197554.1 135 1.62156e-61 PREDICTED: Tribolium castaneum protein SOX-15-like (LOC661892), transcript variant X2, mRNA K09268 SOX4_11_12 transcription factor SOX4/11/12 (SOX group C) http://www.genome.jp/dbget-bin/www_bget?ko:K09268 P40656 411 2.3e-38 Putative transcription factor SOX-14 OS=Drosophila melanogaster GN=Sox14 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.33684 BF_2 247.31 2.80 3984 478257987 ENN78125.1 2376 8.0e-265 hypothetical protein YQE_05279, partial [Dendroctonus ponderosae] 198451987 XM_001358537.2 567 0 Drosophila pseudoobscura pseudoobscura GA21805 (Dpse\GA21805), partial mRNA K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q86XK2 2044 1.0e-227 F-box only protein 11 OS=Homo sapiens GN=FBXO11 PE=1 SV=3 PF07839//PF02207//PF03284 Plant calmodulin-binding domain//Putative zinc finger in N-recognin (UBR box)//Phenazine biosynthesis protein A/B GO:0017000 antibiotic biosynthetic process GO:0008270//GO:0005516 zinc ion binding//calmodulin binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.33685 BF_2 2765.87 55.63 2367 91089295 XP_971418.1 1381 1.1e-149 PREDICTED: membrane-bound alkaline phosphatase [Tribolium castaneum]>gi|270012503|gb|EFA08951.1| hypothetical protein TcasGA2_TC006658 [Tribolium castaneum] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1073 2.4e-115 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00245//PF01663//PF01676 Alkaline phosphatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Metalloenzyme superfamily GO:0008152 metabolic process GO:0016787//GO:0003824//GO:0016791//GO:0046872 hydrolase activity//catalytic activity//phosphatase activity//metal ion binding -- -- -- -- Cluster-8309.33687 BF_2 36.96 0.69 2541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33691 BF_2 116.86 1.10 4748 642915350 XP_008190583.1 277 2.3e-21 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q86MW9 234 9.3e-18 E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni GN=SINA PE=1 SV=1 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.33692 BF_2 119.57 0.81 6448 91089955 XP_973514.1 1912 8.2e-211 PREDICTED: nucleolar protein 56 [Tribolium castaneum]>gi|270013678|gb|EFA10126.1| hypothetical protein TcasGA2_TC012306 [Tribolium castaneum] -- -- -- -- -- K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 1499 2.6e-164 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF05557//PF02376 Mitotic checkpoint protein//CUT domain GO:0007094 mitotic spindle assembly checkpoint GO:0003677 DNA binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-8309.33693 BF_2 1685.64 14.34 5203 91089955 XP_973514.1 1912 6.6e-211 PREDICTED: nucleolar protein 56 [Tribolium castaneum]>gi|270013678|gb|EFA10126.1| hypothetical protein TcasGA2_TC012306 [Tribolium castaneum] 642933836 XM_008199307.1 189 2.04076e-91 PREDICTED: Tribolium castaneum epsin-like protein (LOC662353), transcript variant X1, mRNA K14564 NOP56 nucleolar protein 56 http://www.genome.jp/dbget-bin/www_bget?ko:K14564 Q3SZ63 1499 2.1e-164 Nucleolar protein 56 OS=Bos taurus GN=NOP56 PE=2 SV=1 PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- KOG2573 Ribosome biogenesis protein - Nop56p/Sik1p Cluster-8309.33695 BF_2 577.10 13.32 2099 642930890 XP_008196128.1 375 4.5e-33 PREDICTED: protein-methionine sulfoxide oxidase MICAL3 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 208 4.3e-15 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33696 BF_2 521.91 4.42 5225 478262788 ENN81305.1 4123 0.0e+00 hypothetical protein YQE_02273, partial [Dendroctonus ponderosae]>gi|546672906|gb|ERL84622.1| hypothetical protein D910_02050 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2V2M9 1512 6.6e-166 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF06371 Diaphanous GTPase-binding Domain GO:0030036 actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.33697 BF_2 1117.21 12.89 3913 91089461 XP_968383.1 1941 2.2e-214 PREDICTED: fatty-acid amide hydrolase 2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6GMR7 1103 1.3e-118 Fatty-acid amide hydrolase 2 OS=Homo sapiens GN=FAAH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.33698 BF_2 57.77 0.58 4477 91091526 XP_970162.1 4481 0.0e+00 PREDICTED: tolloid-like protein 1 [Tribolium castaneum]>gi|270001271|gb|EEZ97718.1| hypothetical protein TcasGA2_TC011197 [Tribolium castaneum] 572267902 XM_006611951.1 168 8.27694e-80 PREDICTED: Apis dorsata tolloid-like protein 2-like (LOC102680377), transcript variant X2, mRNA K13046 tok tolkin http://www.genome.jp/dbget-bin/www_bget?ko:K13046 Q9DER7 2700 9.9e-304 Tolloid-like protein 1 OS=Gallus gallus GN=TLL1 PE=2 SV=1 PF00008//PF07645//PF01400//PF00413 EGF-like domain//Calcium-binding EGF domain//Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0005515//GO:0008270//GO:0005509//GO:0004222 protein binding//zinc ion binding//calcium ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.33699 BF_2 760.21 31.59 1294 270010524 EFA06972.1 1424 6.3e-155 hypothetical protein TcasGA2_TC009932 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI7 662 6.0e-68 Upstream-binding protein 1 OS=Homo sapiens GN=UBP1 PE=1 SV=1 PF00918 Gastrin/cholecystokinin family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region KOG4091 Transcription factor Cluster-8309.33701 BF_2 635.57 14.57 2112 478251082 ENN71558.1 894 3.0e-93 hypothetical protein YQE_11660, partial [Dendroctonus ponderosae]>gi|546671909|gb|ERL84016.1| hypothetical protein D910_01335 [Dendroctonus ponderosae]>gi|546671968|gb|ERL84050.1| hypothetical protein D910_01379 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P04572 289 1.7e-24 Sarcoplasmic calcium-binding protein OS=Perinereis vancaurica tetradentata PE=1 SV=1 PF13202//PF00036//PF08119//PF10591//PF13833//PF13405//PF05983//PF13499 EF hand//EF hand//Scorpion acidic alpha-KTx toxin family//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//MED7 protein//EF-hand domain pair GO:0006357//GO:0009405//GO:0007165//GO:0006810 regulation of transcription from RNA polymerase II promoter//pathogenesis//signal transduction//transport GO:0005509//GO:0001104//GO:0019870 calcium ion binding//RNA polymerase II transcription cofactor activity//potassium channel inhibitor activity GO:0005576//GO:0005578//GO:0016592 extracellular region//proteinaceous extracellular matrix//mediator complex -- -- Cluster-8309.33702 BF_2 64.24 0.99 2994 662184253 XP_008470884.1 188 3.1e-11 PREDICTED: uncharacterized protein LOC103508110 isoform X2 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00522 VPR/VPX protein GO:0019058 viral life cycle -- -- GO:0042025 host cell nucleus -- -- Cluster-8309.33703 BF_2 53.56 2.99 1036 91090252 XP_969934.1 406 5.6e-37 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 1.2e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.33704 BF_2 801.84 9.72 3738 478262788 ENN81305.1 4017 0.0e+00 hypothetical protein YQE_02273, partial [Dendroctonus ponderosae]>gi|546672906|gb|ERL84622.1| hypothetical protein D910_02050 [Dendroctonus ponderosae] 642918459 XM_008193262.1 377 0 PREDICTED: Tribolium castaneum FH1/FH2 domain-containing protein 3 (LOC659452), transcript variant X5, mRNA -- -- -- -- Q2V2M9 1472 2.0e-161 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF06371//PF01059 Diaphanous GTPase-binding Domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0055114//GO:0030036//GO:0006120 oxidation-reduction process//actin cytoskeleton organization//mitochondrial electron transport, NADH to ubiquinone GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.33706 BF_2 176.53 1.66 4736 642918460 XP_008191484.1 4422 0.0e+00 PREDICTED: FH1/FH2 domain-containing protein 3 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2V2M9 1472 2.6e-161 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF06371//PF01059 Diaphanous GTPase-binding Domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006120//GO:0030036//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//actin cytoskeleton organization//oxidation-reduction process GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.33707 BF_2 191.73 1.95 4396 607367304 EZA61451.1 490 4.3e-46 Serine/arginine-rich splicing factor, partial [Cerapachys biroi] 195401199 XM_002059166.1 102 3.97259e-43 Drosophila virilis GJ16161 (Dvir\GJ16161), mRNA K12891 SFRS2 splicing factor, arginine/serine-rich 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12891 Q06A98 418 4.0e-39 Serine/arginine-rich splicing factor 2 OS=Sus scrofa GN=SRSF2 PE=2 SV=1 PF03106//PF04805//PF00042//PF00076//PF05001 WRKY DNA -binding domain//E10-like protein conserved region//Globin//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA polymerase Rpb1 C-terminal repeat GO:0006366//GO:0055114//GO:0006355 transcription from RNA polymerase II promoter//oxidation-reduction process//regulation of transcription, DNA-templated GO:0019825//GO:0003677//GO:0003700//GO:0020037//GO:0016972//GO:0043565//GO:0003676 oxygen binding//DNA binding//transcription factor activity, sequence-specific DNA binding//heme binding//thiol oxidase activity//sequence-specific DNA binding//nucleic acid binding GO:0005667//GO:0005665 transcription factor complex//DNA-directed RNA polymerase II, core complex KOG4207 Predicted splicing factor, SR protein superfamily Cluster-8309.33712 BF_2 201.02 2.26 4010 642928023 XP_008200123.1 3052 0.0e+00 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X1 [Tribolium castaneum]>gi|270010887|gb|EFA07335.1| hypothetical protein TcasGA2_TC015931 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.78438e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q60902 1273 2.6e-138 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3 PF10186//PF12763//PF13833//PF13405//PF13499//PF00750//PF13202//PF00036 Vacuolar sorting 38 and autophagy-related subunit 14//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//tRNA synthetases class I (R)//EF hand//EF hand GO:0006525//GO:0006560//GO:0006420//GO:0010508 arginine metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//positive regulation of autophagy GO:0005524//GO:0005515//GO:0004814//GO:0005509 ATP binding//protein binding//arginine-tRNA ligase activity//calcium ion binding -- -- KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.33714 BF_2 3369.18 110.04 1568 642936658 XP_973680.2 469 4.2e-44 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC662495 [Tribolium castaneum] -- -- -- -- -- K09027 XBP1 X box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09027 Q3SZZ2 213 8.4e-16 X-box-binding protein 1 OS=Bos taurus GN=XBP1 PE=2 SV=1 PF06005//PF01496//PF00170//PF04632//PF06156//PF07716//PF12767//PF02601//PF03131 Protein of unknown function (DUF904)//V-type ATPase 116kDa subunit family//bZIP transcription factor//Fusaric acid resistance protein family//Protein of unknown function (DUF972)//Basic region leucine zipper//Transcriptional regulator of RNA polII, SAGA, subunit//Exonuclease VII, large subunit//bZIP Maf transcription factor GO:0006810//GO:0006260//GO:0006355//GO:0015992//GO:0015991//GO:0000917//GO:0043093//GO:0006308 transport//DNA replication//regulation of transcription, DNA-templated//proton transport//ATP hydrolysis coupled proton transport//barrier septum assembly//FtsZ-dependent cytokinesis//DNA catabolic process GO:0015078//GO:0043565//GO:0003700//GO:0003677//GO:0008855 hydrogen ion transmembrane transporter activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//exodeoxyribonuclease VII activity GO:0009318//GO:0005737//GO:0005886//GO:0005634//GO:0070461//GO:0005667//GO:0033179 exodeoxyribonuclease VII complex//cytoplasm//plasma membrane//nucleus//SAGA-type complex//transcription factor complex//proton-transporting V-type ATPase, V0 domain KOG4005 Transcription factor XBP-1 Cluster-8309.33715 BF_2 18.26 0.36 2438 642916256 XP_008190949.1 1280 6.0e-138 PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum]>gi|642916258|ref|XP_008190950.1| PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.6e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.33716 BF_2 1166.29 13.39 3930 642918803 XP_008191592.1 1891 1.4e-208 PREDICTED: mitochondrial import receptor subunit TOM70 [Tribolium castaneum]>gi|270005628|gb|EFA02076.1| hypothetical protein TcasGA2_TC007711 [Tribolium castaneum] -- -- -- -- -- K17768 TOM70 mitochondrial import receptor subunit TOM70 http://www.genome.jp/dbget-bin/www_bget?ko:K17768 Q75Q39 1167 5.0e-126 Mitochondrial import receptor subunit TOM70 OS=Rattus norvegicus GN=Tomm70a PE=1 SV=1 PF13181//PF13371//PF13374//PF00515//PF13414//PF06888//PF13176//PF05822 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Putative Phosphatase//Tetratricopeptide repeat//Pyrimidine 5'-nucleotidase (UMPH-1) GO:0008152 metabolic process GO:0008253//GO:0016791//GO:0005515//GO:0000287 5'-nucleotidase activity//phosphatase activity//protein binding//magnesium ion binding GO:0005737 cytoplasm KOG1615 Phosphoserine phosphatase Cluster-8309.33717 BF_2 2.00 29.04 224 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33718 BF_2 307.00 5.69 2543 478260826 ENN80478.1 2360 3.6e-263 hypothetical protein YQE_03083, partial [Dendroctonus ponderosae]>gi|546672566|gb|ERL84378.1| hypothetical protein D910_01808 [Dendroctonus ponderosae]>gi|546672569|gb|ERL84379.1| hypothetical protein D910_01809 [Dendroctonus ponderosae]>gi|546672573|gb|ERL84382.1| hypothetical protein D910_01812 [Dendroctonus ponderosae] -- -- -- -- -- K05034 SLC6A1 solute carrier family 6 (neurotransmitter transporter, GABA) member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05034 P31648 1300 1.2e-141 Sodium- and chloride-dependent GABA transporter 1 OS=Mus musculus GN=Slc6a1 PE=1 SV=2 PF00209//PF06955//PF06596 Sodium:neurotransmitter symporter family//Xyloglucan endo-transglycosylase (XET) C-terminus//Photosystem II reaction centre X protein (PsbX) GO:0006073//GO:0006812//GO:0006836//GO:0015979 cellular glucan metabolic process//cation transport//neurotransmitter transport//photosynthesis GO:0016762//GO:0005328 xyloglucan:xyloglucosyl transferase activity//neurotransmitter:sodium symporter activity GO:0016020//GO:0009523//GO:0016021//GO:0005618//GO:0048046 membrane//photosystem II//integral component of membrane//cell wall//apoplast -- -- Cluster-8309.3372 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33722 BF_2 267.75 3.41 3572 91089929 XP_973045.1 210 1.0e-13 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08114//PF15168//PF02935 ATPase proteolipid family//Triple QxxK/R motif-containing protein family//Cytochrome c oxidase subunit VIIc GO:0006123//GO:0050790//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//regulation of catalytic activity//proton transport GO:0030234//GO:0004129 enzyme regulator activity//cytochrome-c oxidase activity GO:0005789//GO:0045277 endoplasmic reticulum membrane//respiratory chain complex IV -- -- Cluster-8309.33723 BF_2 32.42 1.13 1483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.33724 BF_2 213.00 11.28 1077 91083189 XP_972753.1 649 3.9e-65 PREDICTED: protein CWC15 homolog [Tribolium castaneum]>gi|270006973|gb|EFA03421.1| hypothetical protein TcasGA2_TC013408 [Tribolium castaneum] 617435114 XM_007563115.1 44 1.66022e-11 PREDICTED: Poecilia formosa CWC15 spliceosome-associated protein homolog (S. cerevisiae) (cwc15), mRNA K12863 CWC15 protein CWC15 http://www.genome.jp/dbget-bin/www_bget?ko:K12863 Q5RE65 416 1.7e-39 Spliceosome-associated protein CWC15 homolog OS=Pongo abelii GN=CWC15 PE=2 SV=1 PF04889 Cwf15/Cwc15 cell cycle control protein GO:0000398 mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex KOG3228 Uncharacterized conserved protein Cluster-8309.33725 BF_2 292.25 2.00 6413 642912052 XP_008199072.1 2483 5.0e-277 PREDICTED: nuclear factor 1 B-type isoform X4 [Tribolium castaneum] 58037658 AC152508.3 177 1.17958e-84 Tribolium castaneum BAC T.cast_C29K22 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 Q02780 750 1.8e-77 Nuclear factor 1 A-type OS=Mus musculus GN=Nfia PE=1 SV=1 PF03165//PF00859 MH1 domain//CTF/NF-I family transcription modulation region GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005634//GO:0005667 intracellular//nucleus//transcription factor complex KOG3663 Nuclear factor I Cluster-8309.33726 BF_2 159.00 7.38 1188 201023367 NP_001128425.1 678 1.9e-68 R2D2 protein [Tribolium castaneum]>gi|642930022|ref|XP_008196215.1| PREDICTED: R2D2 protein isoform X1 [Tribolium castaneum]>gi|642930024|ref|XP_008196216.1| PREDICTED: R2D2 protein isoform X1 [Tribolium castaneum]>gi|270009455|gb|EFA05903.1| hypothetical protein TcasGA2_TC008716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXR1 226 2.0e-17 RISC-loading complex subunit tarbp2 OS=Danio rerio GN=tarbp2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33727 BF_2 3466.13 98.11 1765 91083463 XP_971028.1 842 2.7e-87 PREDICTED: peptidyl-prolyl cis-trans isomerase B [Tribolium castaneum]>gi|270010823|gb|EFA07271.1| hypothetical protein TcasGA2_TC014505 [Tribolium castaneum] 699705106 XM_009893823.1 91 2.05417e-37 PREDICTED: Charadrius vociferus peptidylprolyl isomerase C (cyclophilin C) (PPIC), mRNA K03768 PPIB, ppiB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) http://www.genome.jp/dbget-bin/www_bget?ko:K03768 P80311 679 8.7e-70 Peptidyl-prolyl cis-trans isomerase B OS=Bos taurus GN=PPIB PE=1 SV=4 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0880 Peptidyl-prolyl cis-trans isomerase Cluster-8309.33728 BF_2 555.86 18.49 1545 157116634 XP_001658586.1 229 2.8e-16 AAEL007679-PA [Aedes aegypti]>gi|108876369|gb|EAT40594.1| AAEL007679-PA [Aedes aegypti] -- -- -- -- -- K17553 PPP1R11 protein phosphatase 1 regulatory subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K17553 Q568K2 176 1.6e-11 Protein phosphatase 1 regulatory subunit 11 OS=Danio rerio GN=ppp1r11 PE=1 SV=1 PF06800 Sugar transport protein GO:0008643//GO:0034219 carbohydrate transport//carbohydrate transmembrane transport GO:0015144 carbohydrate transmembrane transporter activity GO:0016021 integral component of membrane KOG4102 Uncharacterized conserved protein Cluster-8309.33730 BF_2 35.67 0.48 3386 642934081 XP_008196456.1 1036 1.6e-109 PREDICTED: phosphatase and actin regulator 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.5e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0015031//GO:0016192 protein transport//vesicle-mediated transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.33732 BF_2 474.00 16.68 1476 332375018 AEE62650.1 531 2.6e-51 unknown [Dendroctonus ponderosae]>gi|478263507|gb|ENN81860.1| hypothetical protein YQE_01753, partial [Dendroctonus ponderosae]>gi|478263508|gb|ENN81861.1| hypothetical protein YQE_01753, partial [Dendroctonus ponderosae]>gi|546674179|gb|ERL85624.1| hypothetical protein D910_03043 [Dendroctonus ponderosae] -- -- -- -- -- K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q95108 267 4.3e-22 Thioredoxin, mitochondrial OS=Bos taurus GN=TXN2 PE=1 SV=2 PF00122//PF06645//PF00085//PF00578//PF00003//PF07689 E1-E2 ATPase//Microsomal signal peptidase 12 kDa subunit (SPC12)//Thioredoxin//AhpC/TSA family//7 transmembrane sweet-taste receptor of 3 GCPR//KaiB domain GO:0006465//GO:0048511//GO:0045454//GO:0055114//GO:0007186 signal peptide processing//rhythmic process//cell redox homeostasis//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0016491//GO:0004930//GO:0008233//GO:0046872//GO:0000166//GO:0016209 oxidoreductase activity//G-protein coupled receptor activity//peptidase activity//metal ion binding//nucleotide binding//antioxidant activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex KOG0910 Thioredoxin-like protein Cluster-8309.33736 BF_2 15.16 1.21 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33738 BF_2 1255.75 39.98 1601 642931239 XP_971757.2 1136 2.0e-121 PREDICTED: enoyl-CoA hydratase, mitochondrial [Tribolium castaneum] 589950009 XM_006987599.1 62 2.45693e-21 PREDICTED: Peromyscus maniculatus bairdii enoyl CoA hydratase, short chain, 1, mitochondrial (Echs1), mRNA K07511 ECHS1 enoyl-CoA hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K07511 P34559 892 1.6e-94 Probable enoyl-CoA hydratase, mitochondrial OS=Caenorhabditis elegans GN=ech-6 PE=3 SV=1 PF01343//PF00378//PF16113 Peptidase family S49//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0003824//GO:0016836//GO:0008233 catalytic activity//hydro-lyase activity//peptidase activity -- -- KOG1679 Enoyl-CoA hydratase Cluster-8309.33739 BF_2 46.70 0.31 6631 642925135 XP_008194182.1 2153 9.5e-239 PREDICTED: rho guanine nucleotide exchange factor 7 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 559 2.7e-55 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF00018//PF14604//PF00621//PF10280 SH3 domain//Variant SH3 domain//RhoGEF domain//Mediator complex protein GO:0006357//GO:0035023//GO:0043087 regulation of transcription from RNA polymerase II promoter//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515//GO:0001104 Rho guanyl-nucleotide exchange factor activity//protein binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.33741 BF_2 47.00 14.20 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33742 BF_2 428.00 15.06 1476 91094707 XP_969750.1 1419 2.7e-154 PREDICTED: geranylgeranyl transferase type-2 subunit beta [Tribolium castaneum]>gi|270016521|gb|EFA12967.1| hypothetical protein TcasGA2_TC001418 [Tribolium castaneum] -- -- -- -- -- K05956 RABGGTB geranylgeranyl transferase type-2 subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K05956 P53611 1160 1.2e-125 Geranylgeranyl transferase type-2 subunit beta OS=Homo sapiens GN=RABGGTB PE=1 SV=2 PF00432 Prenyltransferase and squalene oxidase repeat GO:0018344 protein geranylgeranylation GO:0003824//GO:0004663 catalytic activity//Rab geranylgeranyltransferase activity GO:0005968 Rab-protein geranylgeranyltransferase complex KOG0366 Protein geranylgeranyltransferase type II, beta subunit Cluster-8309.33743 BF_2 1159.81 5.29 9466 91091582 XP_968188.1 2520 3.8e-281 PREDICTED: leucine-rich repeat protein soc-2 homolog [Tribolium castaneum]>gi|270001034|gb|EEZ97481.1| hypothetical protein TcasGA2_TC011315 [Tribolium castaneum] 170032990 XM_001844311.1 225 3.61904e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 8.7e-217 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF13180//PF00412//PF14304//PF10468//PF00560//PF00595//PF13855 PDZ domain//LIM domain//Transcription termination and cleavage factor C-terminal//Carboxypeptidase inhibitor I68//Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF)//Leucine rich repeat GO:0007596//GO:0031124//GO:0010951 blood coagulation//mRNA 3'-end processing//negative regulation of endopeptidase activity GO:0008191//GO:0008270//GO:0005515 metalloendopeptidase inhibitor activity//zinc ion binding//protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33745 BF_2 60.46 3.84 945 91087535 XP_970133.1 628 9.3e-63 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] 642930219 XM_965040.2 161 1.32269e-76 PREDICTED: Tribolium castaneum DNA-directed RNA polymerases I, II, and III subunit RPABC3 (LOC658676), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 439 3.1e-42 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.33746 BF_2 237.54 36.28 561 91087535 XP_970133.1 754 1.4e-77 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] 642930219 XM_965040.2 199 5.75e-98 PREDICTED: Tribolium castaneum DNA-directed RNA polymerases I, II, and III subunit RPABC3 (LOC658676), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 559 2.3e-56 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.33747 BF_2 1415.76 49.78 1477 642923778 XP_008193880.1 997 2.4e-105 PREDICTED: zinc finger protein 395 isoform X1 [Tribolium castaneum] 462336375 APGK01037911.1 36 6.4252e-07 Dendroctonus ponderosae Seq01037921, whole genome shotgun sequence -- -- -- -- Q6DFC8 154 5.5e-09 Zinc finger protein 395 OS=Xenopus laevis GN=znf395 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33749 BF_2 42.00 5.14 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.33750 BF_2 2.00 2.25 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33752 BF_2 9.00 0.35 1356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33753 BF_2 1796.67 22.97 3559 270003477 EEZ99924.1 1744 1.4e-191 hypothetical protein TcasGA2_TC002717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 947 1.5e-100 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF13417//PF07651 Glutathione S-transferase, N-terminal domain//ANTH domain -- -- GO:0005543//GO:0005515 phospholipid binding//protein binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.33755 BF_2 14.00 0.40 1751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33756 BF_2 1455.96 10.13 6301 642917185 XP_966369.3 1730 1.0e-189 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like isoform X2 [Tribolium castaneum] 642919330 XM_008193606.1 90 2.67341e-36 PREDICTED: Tribolium castaneum phosphatidylinositol-binding clathrin assembly protein LAP-like (LOC103312595), mRNA -- -- -- -- Q9VI75 944 5.8e-100 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651 ANTH domain -- -- GO:0005543 phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.33757 BF_2 169.33 2.75 2867 270016160 EFA12608.1 391 8.5e-35 hypothetical protein TcasGA2_TC006849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33758 BF_2 5184.49 41.94 5458 478253683 ENN73984.1 622 2.7e-61 hypothetical protein YQE_09419, partial [Dendroctonus ponderosae]>gi|478266021|gb|ENN82657.1| hypothetical protein YQE_00972, partial [Dendroctonus ponderosae] 617660876 XM_007537263.1 115 2.93148e-50 PREDICTED: Erinaceus europaeus ZFP36 ring finger protein-like 2 (ZFP36L2), mRNA K18753 ZFP36L butyrate response factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18753 P47980 385 3.3e-35 Protein TIS11 OS=Drosophila melanogaster GN=Tis11 PE=2 SV=2 PF08352//PF00642 Oligopeptide/dipeptide transporter, C-terminal region//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0015833 peptide transport GO:0046872//GO:0000166//GO:0005524 metal ion binding//nucleotide binding//ATP binding -- -- KOG1677 CCCH-type Zn-finger protein Cluster-8309.33759 BF_2 613.00 30.42 1130 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33760 BF_2 130.00 7.75 989 570341954 AHE77375.1 537 3.5e-52 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 247 6.0e-20 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525//PF01873 Alpha crystallin A chain, N terminal//Domain found in IF2B/IF5 GO:0006413//GO:0007423//GO:0006446 translational initiation//sensory organ development//regulation of translational initiation GO:0003743//GO:0005212 translation initiation factor activity//structural constituent of eye lens GO:0005840 ribosome -- -- Cluster-8309.33761 BF_2 2459.63 52.69 2240 478256359 ENN76549.1 2332 5.6e-260 hypothetical protein YQE_07000, partial [Dendroctonus ponderosae]>gi|546680788|gb|ERL90994.1| hypothetical protein D910_08336 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 274 1.0e-22 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33765 BF_2 991.47 13.59 3340 642914391 XP_008201658.1 2481 4.4e-277 PREDICTED: glutamate receptor ionotropic, delta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62640 330 4.8e-29 Glutamate receptor ionotropic, delta-1 OS=Rattus norvegicus GN=Grid1 PE=2 SV=1 PF00060//PF10613//PF07826 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//IMP cyclohydrolase-like protein GO:0006807//GO:0006811//GO:0006144//GO:0006164//GO:0007268//GO:0007165//GO:0006188 nitrogen compound metabolic process//ion transport//purine nucleobase metabolic process//purine nucleotide biosynthetic process//synaptic transmission//signal transduction//IMP biosynthetic process GO:0003937//GO:0005234//GO:0004970 IMP cyclohydrolase activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0042720//GO:0016020 mitochondrial inner membrane peptidase complex//membrane -- -- Cluster-8309.33766 BF_2 722.64 17.05 2060 478250623 ENN71115.1 494 7.0e-47 hypothetical protein YQE_12048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:1903818//GO:0030431//GO:0032222 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.33768 BF_2 101.39 0.83 5368 642925269 XP_008194486.1 1379 4.3e-149 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 790 3.6e-82 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF00939//PF03600//PF01542 Sodium:sulfate symporter transmembrane region//Citrate transporter//Hepatitis C virus core protein GO:0006810//GO:0055085//GO:0006814 transport//transmembrane transport//sodium ion transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.33771 BF_2 33.00 0.58 2677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33772 BF_2 951.15 5.96 6965 270011709 EFA08157.1 1968 2.8e-217 hypothetical protein TcasGA2_TC005777 [Tribolium castaneum] 642931878 XM_967548.3 364 0 PREDICTED: Tribolium castaneum casein kinase I isoform delta-A (LOC661388), transcript variant X2, mRNA K08959 CSNK1D casein kinase 1, delta http://www.genome.jp/dbget-bin/www_bget?ko:K08959 Q9DC28 1532 4.2e-168 Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2 PF05445//PF00069//PF07714 Poxvirus serine/threonine protein kinase//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.33775 BF_2 721.47 6.84 4701 531444638 AGT57836.1 1136 5.7e-121 cytochrome P450 412a1 [Leptinotarsa decemlineata] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 823 4.6e-86 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF07535//PF00067 DBF zinc finger//Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705//GO:0008270//GO:0003676 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.33776 BF_2 303.31 4.29 3243 642924646 XP_008194378.1 232 2.6e-16 PREDICTED: tensin isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF16686 Leucine rich repeat//ssDNA-binding domain of telomere protection protein -- -- GO:0005515//GO:0043047 protein binding//single-stranded telomeric DNA binding -- -- -- -- Cluster-8309.33778 BF_2 105.89 0.49 9255 189238003 XP_969912.2 3006 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925068|ref|XP_008194156.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925070|ref|XP_008194157.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|270008050|gb|EFA04498.1| hypothetical protein TcasGA2_TC014806 [Tribolium castaneum] 642925074 XM_008195937.1 248 5.79608e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 252 1.5e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF00715//PF05792//PF02196//PF00096//PF13465//PF04988 Interleukin 2//Candida agglutinin-like (ALS)//Raf-like Ras-binding domain//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) GO:0007155//GO:0006955//GO:0008283//GO:0040007//GO:0007165 cell adhesion//immune response//cell proliferation//growth//signal transduction GO:0005134//GO:0046872//GO:0008083//GO:0003677//GO:0005057 interleukin-2 receptor binding//metal ion binding//growth factor activity//DNA binding//receptor signaling protein activity GO:0005893//GO:0005576//GO:0005634 interleukin-2 receptor complex//extracellular region//nucleus -- -- Cluster-8309.33780 BF_2 563.00 29.23 1093 187937187 NP_001120783.1 750 7.7e-77 uncharacterized protein LOC662961 [Tribolium castaneum]>gi|186939599|dbj|BAG30999.1| juvenile hormone acid O-methyltransferase [Tribolium castaneum]>gi|270006469|gb|EFA02917.1| juvenile hormone acid methyltransferase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q767F1 491 3.4e-48 Juvenile hormone acid O-methyltransferase OS=Bombyx mori GN=JHAMT PE=1 SV=1 PF08241//PF01135//PF01209 Methyltransferase domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//ubiE/COQ5 methyltransferase family GO:0046500//GO:0008152//GO:0006464//GO:0006479 S-adenosylmethionine metabolic process//metabolic process//cellular protein modification process//protein methylation GO:0008168//GO:0004719//GO:0016740 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//transferase activity -- -- -- -- Cluster-8309.33781 BF_2 240.59 4.01 2800 642915045 XP_008190387.1 557 4.7e-54 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like isoform X2 [Tribolium castaneum]>gi|270001363|gb|EEZ97810.1| hypothetical protein TcasGA2_TC000174 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QPN6 268 6.3e-22 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 PF00859 CTF/NF-I family transcription modulation region GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.33782 BF_2 72.41 0.72 4485 642915045 XP_008190387.1 557 7.5e-54 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like isoform X2 [Tribolium castaneum]>gi|270001363|gb|EEZ97810.1| hypothetical protein TcasGA2_TC000174 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QPN6 268 1.0e-21 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 PF00859 CTF/NF-I family transcription modulation region GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.33784 BF_2 554.59 2.09 11378 642920322 XP_008192299.1 491 8.6e-46 PREDICTED: transcriptional regulator SKO1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15150 Phorbol-12-myristate-13-acetate-induced GO:0006915//GO:0006974//GO:0001836//GO:0006919 apoptotic process//cellular response to DNA damage stimulus//release of cytochrome c from mitochondria//activation of cysteine-type endopeptidase activity involved in apoptotic process -- -- -- -- -- -- Cluster-8309.33785 BF_2 49.71 2.51 1115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16782 Nucleotide exchange factor SIL1 -- -- GO:0000774 adenyl-nucleotide exchange factor activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.33786 BF_2 124.78 2.48 2396 642937283 XP_008198771.1 222 2.8e-15 PREDICTED: uncharacterized protein LOC103314450 isoform X2 [Tribolium castaneum]>gi|270000842|gb|EEZ97289.1| hypothetical protein TcasGA2_TC011094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33787 BF_2 879.83 8.83 4457 642913045 XP_008201364.1 6278 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] 642913044 XM_008203142.1 597 0 PREDICTED: Tribolium castaneum fibrillin-2 (LOC663193), mRNA -- -- -- -- Q61555 3315 0.0e+00 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.33788 BF_2 2457.25 23.87 4593 642919030 XP_008191704.1 2644 7.7e-296 PREDICTED: MAGUK p55 subfamily member 5-A isoform X2 [Tribolium castaneum] 642919029 XM_008193482.1 520 0 PREDICTED: Tribolium castaneum MAGUK p55 subfamily member 5-A (LOC663614), transcript variant X2, mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 Q8JHF4 1340 5.1e-146 MAGUK p55 subfamily member 5-A OS=Danio rerio GN=mpp5a PE=1 SV=2 PF13180//PF00018//PF14604//PF00595 PDZ domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.33789 BF_2 42.16 0.38 4986 642919028 XP_008191703.1 2645 6.4e-296 PREDICTED: MAGUK p55 subfamily member 5-A isoform X1 [Tribolium castaneum] 642919029 XM_008193482.1 518 0 PREDICTED: Tribolium castaneum MAGUK p55 subfamily member 5-A (LOC663614), transcript variant X2, mRNA K06091 MPP5, PALS1 MAGUK p55 subfamily member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06091 Q8JHF4 1344 1.9e-146 MAGUK p55 subfamily member 5-A OS=Danio rerio GN=mpp5a PE=1 SV=2 PF13180//PF00595//PF14604//PF00018 PDZ domain//PDZ domain (Also known as DHR or GLGF)//Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.3379 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33790 BF_2 16.62 1.11 916 189240524 XP_971875.2 546 2.9e-53 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] 808139336 XM_003400646.2 154 9.96983e-73 PREDICTED: Bombus terrestris 60S ribosomal protein L3 (LOC100646559), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 498 4.4e-49 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.33791 BF_2 34.99 1.26 1451 761901546 XP_011404925.1 340 3.5e-29 PREDICTED: uncharacterized protein LOC100639010 [Amphimedon queenslandica] -- -- -- -- -- -- -- -- -- Q1RK13 304 2.2e-26 Putative ankyrin repeat protein RBE_0220 OS=Rickettsia bellii (strain RML369-C) GN=RBE_0220 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33794 BF_2 2535.25 33.65 3439 478252006 ENN72441.1 2826 0.0e+00 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1423 9.1e-156 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF05173//PF01433 Dihydrodipicolinate reductase, C-terminus//Peptidase family M1 GO:0009089//GO:0009085//GO:0055114 lysine biosynthetic process via diaminopimelate//lysine biosynthetic process//oxidation-reduction process GO:0008839//GO:0008237//GO:0008270 4-hydroxy-tetrahydrodipicolinate reductase//metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.33795 BF_2 48.23 0.70 3153 91078902 XP_973455.1 618 4.5e-61 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q9ER00 283 1.3e-23 Syntaxin-12 OS=Mus musculus GN=Stx12 PE=1 SV=1 PF00015//PF03936//PF03938//PF05739//PF17082//PF08702//PF04632//PF05478//PF02561//PF05531//PF00957//PF01829//PF00804//PF14942 Methyl-accepting chemotaxis protein (MCP) signalling domain//Terpene synthase family, metal binding domain//Outer membrane protein (OmpH-like)//SNARE domain//Spindle Pole Component 29//Fibrinogen alpha/beta chain family//Fusaric acid resistance protein family//Prominin//Flagellar protein FliS//Nucleopolyhedrovirus P10 protein//Synaptobrevin//Peptidase A6 family//Syntaxin//Organelle biogenesis, Muted-like protein GO:0030168//GO:0006508//GO:0030474//GO:0007165//GO:0051258//GO:0006810//GO:0016192 platelet activation//proteolysis//spindle pole body duplication//signal transduction//protein polymerization//transport//vesicle-mediated transport GO:0030674//GO:0004871//GO:0010333//GO:0000287//GO:0004190//GO:0005515//GO:0051082//GO:0005200//GO:0005102//GO:0016829 protein binding, bridging//signal transducer activity//terpene synthase activity//magnesium ion binding//aspartic-type endopeptidase activity//protein binding//unfolded protein binding//structural constituent of cytoskeleton//receptor binding//lyase activity GO:0016020//GO:0031083//GO:0030133//GO:0005856//GO:0005886//GO:0005823//GO:0009288//GO:0005577//GO:0019028//GO:0016021 membrane//BLOC-1 complex//transport vesicle//cytoskeleton//plasma membrane//central plaque of spindle pole body//bacterial-type flagellum//fibrinogen complex//viral capsid//integral component of membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.33796 BF_2 8.00 4.71 354 91095123 XP_970890.1 430 3.2e-40 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 269 6.1e-23 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01912//PF16794 short chain dehydrogenase//eIF-6 family//Fibronectin-III type domain GO:0042256//GO:0008152//GO:0055114 mature ribosome assembly//metabolic process//oxidation-reduction process GO:0043022//GO:0000166//GO:0016491//GO:0005515 ribosome binding//nucleotide binding//oxidoreductase activity//protein binding -- -- -- -- Cluster-8309.33797 BF_2 23.91 0.61 1932 91086655 XP_967836.1 1633 5.5e-179 PREDICTED: minor histocompatibility antigen H13 [Tribolium castaneum]>gi|270010389|gb|EFA06837.1| hypothetical protein TcasGA2_TC009780 [Tribolium castaneum] -- -- -- -- -- K09595 HM13 minor histocompatibility antigen H13 http://www.genome.jp/dbget-bin/www_bget?ko:K09595 Q8TCT9 1155 6.1e-125 Minor histocompatibility antigen H13 OS=Homo sapiens GN=HM13 PE=1 SV=1 PF01080//PF04258 Presenilin//Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.33799 BF_2 38.00 1.15 1664 215274049 ACJ64922.1 323 3.8e-27 nicotinic acetylcholine receptor alpha 8 [Leptinotarsa decemlineata] -- -- -- -- -- K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P25162 239 8.6e-19 Acetylcholine receptor subunit beta-like 2 OS=Drosophila melanogaster GN=nAChRbeta2 PE=2 SV=3 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.33803 BF_2 6243.47 178.18 1753 91087113 XP_975150.1 1013 3.9e-107 PREDICTED: ras-related protein Rab-1A [Tribolium castaneum]>gi|270010550|gb|EFA06998.1| hypothetical protein TcasGA2_TC009965 [Tribolium castaneum] 121543894 EF070546.1 188 2.44124e-91 Maconellicoccus hirsutus clone WHMH3840 putative RAB1 mRNA, complete cds K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q05974 930 6.8e-99 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF03193//PF00005//PF00071//PF10662//PF04670//PF01926//PF08477//PF07728//PF02421//PF00025//PF00004 Protein of unknown function, DUF258//ABC transporter//Ras family//Ethanolamine utilisation - propanediol utilisation//Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//Ferrous iron transport protein B//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA) GO:0006576//GO:0015031//GO:0015684//GO:0007264 cellular biogenic amine metabolic process//protein transport//ferrous iron transport//small GTPase mediated signal transduction GO:0005524//GO:0015093//GO:0003924//GO:0016887//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.33804 BF_2 1248.67 75.18 982 91091622 XP_969824.1 279 2.8e-22 PREDICTED: waprin-Rha1 [Tribolium castaneum]>gi|270001284|gb|EEZ97731.1| WAP four-disulfide core domain-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.33805 BF_2 121.23 1.63 3399 642919577 XP_008191928.1 2294 2.2e-255 PREDICTED: heat shock 70 kDa protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 Q5R606 1519 6.6e-167 Heat shock protein 105 kDa OS=Pongo abelii GN=HSPH1 PE=2 SV=1 PF04355//PF06723 SmpA / OmlA family//MreB/Mbl protein GO:0000902 cell morphogenesis -- -- GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.33807 BF_2 17.80 0.36 2384 546674013 ERL85506.1 883 6.3e-92 hypothetical protein D910_02925 [Dendroctonus ponderosae] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q06068 423 5.7e-40 97 kDa heat shock protein OS=Strongylocentrotus purpuratus PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.33808 BF_2 10.96 0.56 1102 91092196 XP_969285.1 382 3.6e-34 PREDICTED: plasminogen receptor (KT) isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HBL7 162 4.8e-10 Plasminogen receptor (KT) OS=Homo sapiens GN=PLGRKT PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33809 BF_2 998.29 9.57 4652 283046738 NP_001164316.1 941 2.3e-98 TAK1-associated binding protein 2 isoform A [Tribolium castaneum]>gi|270012754|gb|EFA09202.1| Tab2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K90 180 1.7e-11 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Mus musculus GN=Tab2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.33810 BF_2 680.37 19.34 1759 546683303 ERL93135.1 670 2.3e-67 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 428 1.1e-40 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF06305 Trypsin//Protein of unknown function (DUF1049) GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.33811 BF_2 66.62 0.95 3234 546682290 ERL92248.1 263 6.7e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 203 2.5e-14 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.33812 BF_2 1253.00 39.21 1624 91079180 XP_968196.1 313 5.4e-26 PREDICTED: cylicin-2 [Tribolium castaneum]>gi|270004244|gb|EFA00692.1| hypothetical protein TcasGA2_TC003571 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00951//PF06624 Arterivirus GL envelope glycoprotein//Ribosome associated membrane protein RAMP4 -- -- -- -- GO:0005783//GO:0019031 endoplasmic reticulum//viral envelope -- -- Cluster-8309.33815 BF_2 267.00 11.91 1225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.33816 BF_2 108.13 1.68 2975 546672114 ERL84135.1 1143 5.6e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.1e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.33817 BF_2 263.00 8.31 1611 91077474 XP_968267.1 2241 1.4e-249 PREDICTED: pleiotropic regulator 1 [Tribolium castaneum]>gi|642914017|ref|XP_008201512.1| PREDICTED: pleiotropic regulator 1 [Tribolium castaneum]>gi|270002139|gb|EEZ98586.1| hypothetical protein TcasGA2_TC001100 [Tribolium castaneum] -- -- -- -- -- K12862 PLRG1, PRL1, PRP46 pleiotropic regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12862 Q922V4 1517 5.3e-167 Pleiotropic regulator 1 OS=Mus musculus GN=Plrg1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0285 Pleiotropic regulator 1 Cluster-8309.33819 BF_2 6.64 0.48 867 195335719 XP_002034511.1 360 1.0e-31 GM21919 [Drosophila sechellia]>gi|194126481|gb|EDW48524.1| GM21919 [Drosophila sechellia] 195335718 XM_002034475.1 84 7.70282e-34 Drosophila sechellia GM21919 (Dsec\GM21919), mRNA K17081 PHB2 prohibitin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17081 O35129 304 1.3e-26 Prohibitin-2 OS=Mus musculus GN=Phb2 PE=1 SV=1 PF09367 CpeS-like protein GO:0017009 protein-phycocyanobilin linkage -- -- -- -- KOG3090 Prohibitin-like protein Cluster-8309.33820 BF_2 264.18 12.78 1152 91085035 XP_974101.1 1303 6.1e-141 PREDICTED: prohibitin-2 isoform X1 [Tribolium castaneum]>gi|270009028|gb|EFA05476.1| hypothetical protein TcasGA2_TC015660 [Tribolium castaneum] 195487314 XM_002091822.1 126 4.64275e-57 Drosophila yakuba GE12002 (Dyak\GE12002), partial mRNA K17081 PHB2 prohibitin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17081 Q99623 1042 4.6e-112 Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 -- -- -- -- -- -- GO:0016020 membrane KOG3090 Prohibitin-like protein Cluster-8309.33821 BF_2 49.79 1.45 1727 642910690 XP_008200062.1 440 1.1e-40 PREDICTED: serine protease snake [Tribolium castaneum]>gi|270015111|gb|EFA11559.1| serine protease P44 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 289 1.4e-24 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF03340 Trypsin//Poxvirus rifampicin resistance protein GO:0046677//GO:0006508 response to antibiotic//proteolysis GO:0008236//GO:0004252 serine-type peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.33822 BF_2 206.00 2.40 3875 759068314 XP_011343656.1 171 3.7e-09 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X4 [Cerapachys biroi] 407731587 JQ771511.1 89 5.89475e-36 Labidomera clivicollis Na+,K+ ATPase alpha-subunit 1 mRNA, partial cds -- -- -- -- P28774 153 1.9e-08 Sodium/potassium-transporting ATPase subunit alpha-B OS=Artemia franciscana PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.33823 BF_2 1413.00 40.94 1731 728418110 AIY68357.1 1347 7.2e-146 esterase [Leptinotarsa decemlineata] 685824196 LN609396.1 36 7.55696e-07 Strongyloides ratti genome assembly S_ratti_ED321 ,scaffold srae_chrx_scaffold0000002 -- -- -- -- B2D0J5 583 1.2e-58 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.33824 BF_2 8.24 0.31 1396 195381207 XP_002049346.1 228 3.3e-16 GJ21535 [Drosophila virilis]>gi|194144143|gb|EDW60539.1| GJ21535 [Drosophila virilis] -- -- -- -- -- K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 221 8.8e-17 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094//GO:0006099 gluconeogenesis//tricarboxylic acid cycle GO:0004613//GO:0004611//GO:0005525 phosphoenolpyruvate carboxykinase (GTP) activity//phosphoenolpyruvate carboxykinase activity//GTP binding -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.33826 BF_2 35.67 0.57 2893 332376827 AEE63553.1 2731 4.0e-306 unknown [Dendroctonus ponderosae] 759182915 XM_011381699.1 369 0 PREDICTED: Pteropus vampyrus protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant X1, mRNA K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 Q76MZ3 2356 5.0e-264 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 PF02985//PF01602 HEAT repeat//Adaptin N terminal region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.33827 BF_2 808.64 15.00 2542 478255194 ENN75423.1 2734 1.6e-306 hypothetical protein YQE_07974, partial [Dendroctonus ponderosae] 759182915 XM_011381699.1 369 0 PREDICTED: Pteropus vampyrus protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant X1, mRNA K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 Q76MZ3 2356 4.3e-264 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 PF02985//PF01602 HEAT repeat//Adaptin N terminal region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.33829 BF_2 7550.51 81.16 4179 478251222 ENN71696.1 1228 1.1e-131 hypothetical protein YQE_11619, partial [Dendroctonus ponderosae] 315115388 HQ424723.1 158 2.79688e-74 Euphydryas aurinia ribosomal protein S15 (RpS15) mRNA, complete cds K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 Q9W6S3 537 6.0e-53 Target of rapamycin complex 2 subunit MAPKAP1 OS=Gallus gallus GN=MAPKAP1 PE=2 SV=1 PF00203//PF04145//PF00654 Ribosomal protein S19//Ctr copper transporter family//Voltage gated chloride channel GO:0006821//GO:0006825//GO:0006412//GO:0055085//GO:0042254//GO:0035434 chloride transport//copper ion transport//translation//transmembrane transport//ribosome biogenesis//copper ion transmembrane transport GO:0005375//GO:0003735//GO:0005247 copper ion transmembrane transporter activity//structural constituent of ribosome//voltage-gated chloride channel activity GO:0016021//GO:0005840//GO:0016020 integral component of membrane//ribosome//membrane KOG0898 40S ribosomal protein S15 Cluster-8309.33830 BF_2 886.89 47.45 1069 642937828 XP_008200318.1 731 1.2e-74 PREDICTED: ethanolamine kinase 2 [Tribolium castaneum] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 576 4.6e-58 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 PF05296 Taste receptor protein (TAS2R) GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4720 Ethanolamine kinase Cluster-8309.33831 BF_2 960.59 10.49 4119 642937828 XP_008200318.1 862 3.0e-89 PREDICTED: ethanolamine kinase 2 [Tribolium castaneum] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 835 1.7e-87 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 PF05296 Taste receptor protein (TAS2R) GO:0050909//GO:0007186 sensory perception of taste//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG4720 Ethanolamine kinase Cluster-8309.33832 BF_2 91.96 2.54 1800 642918470 XP_008191489.1 1521 5.0e-166 PREDICTED: protein NDRG3 isoform X2 [Tribolium castaneum] 462464055 APGK01005064.1 69 3.55686e-25 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 1.7e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.33833 BF_2 24.40 0.48 2427 642933276 XP_008197354.1 1014 4.1e-107 PREDICTED: cell wall protein RBR3 isoform X1 [Tribolium castaneum] 817211936 XM_012426709.1 59 1.74603e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.1e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33835 BF_2 277.00 75.10 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33836 BF_2 119.04 1.16 4585 642938616 XP_008199867.1 1598 1.5e-174 PREDICTED: epidermal growth factor receptor kinase substrate 8 [Tribolium castaneum] -- -- -- -- -- K17277 EPS8 epidermal growth factor receptor kinase substrate 8 http://www.genome.jp/dbget-bin/www_bget?ko:K17277 Q12929 465 1.5e-44 Epidermal growth factor receptor kinase substrate 8 OS=Homo sapiens GN=EPS8 PE=1 SV=1 PF08416//PF00536//PF02198//PF14604//PF00018 Phosphotyrosine-binding domain//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain//Variant SH3 domain//SH3 domain -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus KOG3557 Epidermal growth factor receptor kinase substrate Cluster-8309.33837 BF_2 167.70 5.12 1657 642929641 XP_008195916.1 174 7.2e-10 PREDICTED: uncharacterized protein LOC664363 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.33839 BF_2 530.00 11.70 2182 -- -- -- -- -- 301172695 NR_036272.1 47 7.34323e-13 Tribolium castaneum microRNA mir-1 (Mir1), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33840 BF_2 383.50 6.71 2677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33841 BF_2 1444.25 12.73 5032 270002885 EEZ99332.1 703 9.9e-71 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75096 311 1.2e-26 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF03875//PF00057//PF07415//PF00089 Statherin//Low-density lipoprotein receptor domain class A//Gammaherpesvirus latent membrane protein (LMP2) protein//Trypsin GO:0030500//GO:0042742//GO:0019042//GO:0006508 regulation of bone mineralization//defense response to bacterium//viral latency//proteolysis GO:0046848//GO:0005515//GO:0004252 hydroxyapatite binding//protein binding//serine-type endopeptidase activity GO:0005576//GO:0033644 extracellular region//host cell membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.33843 BF_2 652.94 70.79 673 478250183 ENN70686.1 762 1.9e-78 hypothetical protein YQE_12631, partial [Dendroctonus ponderosae]>gi|546682381|gb|ERL92323.1| hypothetical protein D910_09640 [Dendroctonus ponderosae] -- -- -- -- -- K03952 NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03952 Q9DCJ5 352 2.7e-32 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 OS=Mus musculus GN=Ndufa8 PE=1 SV=3 PF05676//PF02297 NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Cytochrome oxidase c subunit VIb GO:0015992//GO:0006814//GO:0006118//GO:0006744//GO:0006123//GO:0006120 proton transport//sodium ion transport//obsolete electron transport//ubiquinone biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//mitochondrial electron transport, NADH to ubiquinone GO:0004129//GO:0008137//GO:0003954 cytochrome-c oxidase activity//NADH dehydrogenase (ubiquinone) activity//NADH dehydrogenase activity GO:0005739//GO:0045277 mitochondrion//respiratory chain complex IV KOG3458 NADH:ubiquinone oxidoreductase, NDUFA8/PGIV/19 kDa subunit Cluster-8309.33844 BF_2 482.13 5.11 4236 91081353 XP_971021.1 1303 2.2e-140 PREDICTED: protein FAM114A2 [Tribolium castaneum]>gi|270005192|gb|EFA01640.1| hypothetical protein TcasGA2_TC007210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDV3 509 1.1e-49 Probable nucleoporin Nup58 OS=Drosophila melanogaster GN=Nup58 PE=2 SV=1 PF14620//PF08515//PF04029//PF00435 YpeB sporulation//Transforming growth factor beta type I GS-motif//2-phosphosulpholactate phosphatase//Spectrin repeat GO:0009847//GO:0016310//GO:0006468//GO:0009069//GO:0007178 spore germination//phosphorylation//protein phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0000287//GO:0050532//GO:0004675//GO:0005515//GO:0005524 magnesium ion binding//2-phosphosulfolactate phosphatase activity//transmembrane receptor protein serine/threonine kinase activity//protein binding//ATP binding GO:0016020 membrane KOG0845 Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) Cluster-8309.33845 BF_2 1.00 4.96 253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33846 BF_2 7410.25 381.37 1100 91077560 XP_972368.1 1371 7.5e-149 PREDICTED: sorbitol dehydrogenase [Tribolium castaneum]>gi|270002168|gb|EEZ98615.1| hypothetical protein TcasGA2_TC001137 [Tribolium castaneum] -- -- -- -- -- K00008 SORD, gutB L-iditol 2-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00008 Q58D31 981 5.2e-105 Sorbitol dehydrogenase OS=Bos taurus GN=SORD PE=2 SV=3 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0008270//GO:0000166//GO:0016491//GO:0046872 zinc ion binding//nucleotide binding//oxidoreductase activity//metal ion binding -- -- KOG0024 Sorbitol dehydrogenase Cluster-8309.33847 BF_2 1520.70 33.10 2209 332374856 AEE62569.1 2227 8.3e-248 unknown [Dendroctonus ponderosae] 769836104 XM_011649878.1 162 8.77338e-77 PREDICTED: Pogonomyrmex barbatus T-complex protein 1 subunit epsilon (LOC105434223), mRNA K09497 CCT5 T-complex protein 1 subunit epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09497 Q4R6V2 1924 4.7e-214 T-complex protein 1 subunit epsilon OS=Macaca fascicularis GN=CCT5 PE=2 SV=1 PF00118//PF07546 TCP-1/cpn60 chaperonin family//EMI domain -- -- GO:0005515//GO:0005524 protein binding//ATP binding -- -- KOG0357 Chaperonin complex component, TCP-1 epsilon subunit (CCT5) Cluster-8309.33848 BF_2 1353.36 24.23 2624 91087475 XP_967673.1 2015 3.8e-223 PREDICTED: 26S protease regulatory subunit 6A-B [Tribolium castaneum]>gi|270010662|gb|EFA07110.1| hypothetical protein TcasGA2_TC010100 [Tribolium castaneum] 54287935 AY750868.1 407 0 Toxoptera citricida putative 26S protease regulatory subunit 6A mRNA, complete cds K03065 PSMC3, RPT5 26S proteasome regulatory subunit T5 http://www.genome.jp/dbget-bin/www_bget?ko:K03065 Q63569 1805 3.5e-200 26S protease regulatory subunit 6A OS=Rattus norvegicus GN=Psmc3 PE=2 SV=1 PF00005//PF02562//PF00910//PF07728//PF01695//PF00158//PF05496//PF00004//PF07724 ABC transporter//PhoH-like protein//RNA helicase//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily) GO:0006281//GO:0006355//GO:0006310//GO:0030163 DNA repair//regulation of transcription, DNA-templated//DNA recombination//protein catabolic process GO:0005524//GO:0003723//GO:0008134//GO:0016887//GO:0017111//GO:0009378//GO:0003724 ATP binding//RNA binding//transcription factor binding//ATPase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//RNA helicase activity GO:0005657//GO:0009379//GO:0005667//GO:0005737 replication fork//Holliday junction helicase complex//transcription factor complex//cytoplasm KOG0652 26S proteasome regulatory complex, ATPase RPT5 Cluster-8309.33851 BF_2 1510.36 8.58 7647 642933138 XP_008197272.1 7873 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 13 isoform X1 [Tribolium castaneum] 642933139 XM_008199051.1 239 4.81898e-119 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 2.8e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF14672//PF06333//PF02671 Late cornified envelope//Mediator complex subunit 13 C-terminal//Paired amphipathic helix repeat GO:0006355//GO:0006357//GO:0008544 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//epidermis development GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.33853 BF_2 21745.54 208.69 4646 91078972 XP_974414.1 2664 3.7e-298 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1610 2.5e-177 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0046872//GO:0003810 metal ion binding//protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.33856 BF_2 1233.09 9.67 5624 642937777 XP_008198941.1 5493 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X3 [Tribolium castaneum] 665815760 XM_008558331.1 166 1.34722e-78 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 3294 0.0e+00 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0206 P-type ATPase Cluster-8309.33857 BF_2 1512.00 97.63 935 642925507 XP_008194579.1 284 7.1e-23 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane -- -- Cluster-8309.33858 BF_2 177.54 2.91 2842 642925507 XP_008194579.1 1060 2.3e-112 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.42634e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 773 1.8e-80 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.33860 BF_2 241.82 8.32 1503 91086669 XP_968223.1 832 3.3e-86 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K2G1 548 1.1e-54 Proteasomal ubiquitin receptor ADRM1 homolog OS=Drosophila melanogaster GN=Rpn13 PE=1 SV=1 PF04683//PF05460//PF03999 Proteasome complex subunit Rpn13 ubiquitin receptor//Origin recognition complex subunit 6 (ORC6)//Microtubule associated protein (MAP65/ASE1 family) GO:0000226//GO:0006260//GO:0000910 microtubule cytoskeleton organization//DNA replication//cytokinesis GO:0008017//GO:0003677 microtubule binding//DNA binding GO:0005737//GO:0045298//GO:0005664//GO:0005634 cytoplasm//tubulin complex//nuclear origin of replication recognition complex//nucleus KOG3037 Cell membrane glycoprotein Cluster-8309.33861 BF_2 49.74 1.71 1505 642936042 XP_008198279.1 685 3.6e-69 PREDICTED: annexin B9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 525 5.3e-52 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF04546//PF00191 Sigma-70, non-essential region//Annexin GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0005544//GO:0003700//GO:0005509//GO:0016987//GO:0003677 calcium-dependent phospholipid binding//transcription factor activity, sequence-specific DNA binding//calcium ion binding//sigma factor activity//DNA binding GO:0005667 transcription factor complex KOG0819 Annexin Cluster-8309.33862 BF_2 109.19 0.99 4911 91092640 XP_969145.1 1955 6.4e-216 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.3e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005634 nucleus KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.33866 BF_2 4142.14 107.97 1892 332373948 AEE62115.1 1084 2.5e-115 unknown [Dendroctonus ponderosae]>gi|478255033|gb|ENN75265.1| hypothetical protein YQE_08181, partial [Dendroctonus ponderosae]>gi|546673321|gb|ERL84949.1| hypothetical protein D910_02372 [Dendroctonus ponderosae] 332373947 BT127153.1 266 1.15196e-134 Dendroctonus ponderosae clone DPO1136_C15 unknown mRNA K07904 RAB11A Ras-related protein Rab-11A http://www.genome.jp/dbget-bin/www_bget?ko:K07904 P62493 907 3.4e-96 Ras-related protein Rab-11A OS=Oryctolagus cuniculus GN=RAB11A PE=2 SV=3 PF01926//PF07728//PF08477//PF02421//PF00025//PF03193//PF00005//PF10662//PF00071//PF04670 50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//Protein of unknown function, DUF258//ABC transporter//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region GO:0015684//GO:0007264//GO:0006576 ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process GO:0016887//GO:0005525//GO:0005524//GO:0015093//GO:0003924 ATPase activity//GTP binding//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0087 GTPase Rab11/YPT3, small G protein superfamily Cluster-8309.33867 BF_2 229.88 6.28 1819 642919181 XP_008191771.1 737 4.1e-75 PREDICTED: uncharacterized protein LOC103312580 isoform X1 [Tribolium castaneum]>gi|270005582|gb|EFA02030.1| hypothetical protein TcasGA2_TC007655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33868 BF_2 309.95 6.84 2182 642913109 XP_008201396.1 838 9.6e-87 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 746862007 XM_011063600.1 170 3.09431e-81 PREDICTED: Acromyrmex echinatior protein GDAP2 homolog (LOC105150477), mRNA -- -- -- -- Q7JUR6 686 1.7e-70 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.3387 BF_2 15.41 0.77 1129 642919879 XP_973964.2 335 1.0e-28 PREDICTED: ganglioside GM2 activator [Tribolium castaneum] -- -- -- -- -- K12383 GM2A ganglioside GM2 activator http://www.genome.jp/dbget-bin/www_bget?ko:K12383 Q8HXX6 174 2.0e-11 Ganglioside GM2 activator OS=Macaca fascicularis GN=GM2A PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33872 BF_2 4415.53 164.80 1408 91082141 XP_969473.1 765 1.8e-78 PREDICTED: integral membrane protein 2A [Tribolium castaneum]>gi|270007252|gb|EFA03700.1| hypothetical protein TcasGA2_TC013805 [Tribolium castaneum] -- -- -- -- -- K18264 ITM2B integral membrane protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K18264 Q3T0P7 179 6.6e-12 Integral membrane protein 2B OS=Bos taurus GN=ITM2B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4681 Uncharacterized conserved protein Cluster-8309.33873 BF_2 562.43 14.01 1966 478260661 ENN80358.1 1568 1.9e-171 hypothetical protein YQE_03217, partial [Dendroctonus ponderosae]>gi|546683693|gb|ERL93471.1| hypothetical protein D910_10762 [Dendroctonus ponderosae] 766923044 XM_011507823.1 252 7.26048e-127 PREDICTED: Ceratosolen solmsi marchali protein Mo25 (LOC105368736), transcript variant X2, mRNA K08272 CAB39, MO25 calcium binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K08272 P91891 1408 2.8e-154 Protein Mo25 OS=Drosophila melanogaster GN=Mo25 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1566 Conserved protein Mo25 Cluster-8309.33875 BF_2 53.00 0.53 4469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33876 BF_2 93.93 0.73 5670 752876259 XP_011255518.1 494 1.9e-46 PREDICTED: 60S ribosomal protein L44 [Camponotus floridanus] 642918893 XM_968530.2 160 2.94023e-75 PREDICTED: Tribolium castaneum 60S ribosomal protein L44 (LOC662436), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 450 1.0e-42 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF00935//PF10152//PF02150 Ribosomal protein L44//Predicted coiled-coil domain-containing protein (DUF2360)//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006412//GO:0006206//GO:0042254 transcription, DNA-templated//purine nucleobase metabolic process//translation//pyrimidine nucleobase metabolic process//ribosome biogenesis GO:0003899//GO:0003677//GO:0003735 DNA-directed RNA polymerase activity//DNA binding//structural constituent of ribosome GO:0005840//GO:0005622//GO:0071203//GO:0005730 ribosome//intracellular//WASH complex//nucleolus KOG3464 60S ribosomal protein L44 Cluster-8309.33877 BF_2 99.11 1.90 2466 642923758 XP_008193872.1 854 1.5e-88 PREDICTED: activating signal cointegrator 1 complex subunit 1-like [Tribolium castaneum]>gi|270006936|gb|EFA03384.1| hypothetical protein TcasGA2_TC013370 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D8Z1 288 2.7e-24 Activating signal cointegrator 1 complex subunit 1 OS=Mus musculus GN=Ascc1 PE=2 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG2814 Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) Cluster-8309.33878 BF_2 442.00 4.42 4473 91076478 XP_972409.1 5369 0.0e+00 PREDICTED: slit homolog 3 protein [Tribolium castaneum]>gi|270002880|gb|EEZ99327.1| toll-7-like protein [Tribolium castaneum] 642912522 XM_967316.2 956 0 PREDICTED: Tribolium castaneum toll-like receptor 7 (LOC661135), mRNA -- -- -- -- P35859 435 4.3e-41 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF01582//PF00560//PF13676//PF13855 TIR domain//Leucine Rich Repeat//TIR domain//Leucine rich repeat GO:0007165 signal transduction GO:0005515 protein binding GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.33880 BF_2 3356.34 28.22 5262 270002723 EEZ99170.1 3733 0.0e+00 aminopeptidase-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P79098 740 2.2e-76 Aminopeptidase N OS=Bos taurus GN=ANPEP PE=2 SV=4 PF01433//PF02671 Peptidase family M1//Paired amphipathic helix repeat GO:0006355 regulation of transcription, DNA-templated GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.33881 BF_2 732.97 3.30 9573 642922938 XP_008200459.1 3758 0.0e+00 PREDICTED: symplekin [Tribolium castaneum]>gi|270006545|gb|EFA02993.1| hypothetical protein TcasGA2_TC010414 [Tribolium castaneum] -- -- -- -- -- K06100 SYMPK symplekin http://www.genome.jp/dbget-bin/www_bget?ko:K06100 Q8IYB9 457 2.6e-43 Zinc finger protein 595 OS=Homo sapiens GN=ZNF595 PE=2 SV=1 PF00096//PF00312//PF12689//PF14764//PF13465//PF01025//PF13912//PF03938//PF10018 Zinc finger, C2H2 type//Ribosomal protein S15//Acid Phosphatase//AP-5 complex subunit, vesicle trafficking//Zinc-finger double domain//GrpE//C2H2-type zinc finger//Outer membrane protein (OmpH-like)//Vitamin-D-receptor interacting Mediator subunit 4 GO:0042254//GO:0006357//GO:0006412//GO:0006457 ribosome biogenesis//regulation of transcription from RNA polymerase II promoter//translation//protein folding GO:0003735//GO:0051087//GO:0051082//GO:0000774//GO:0016791//GO:0001104//GO:0046872//GO:0042803 structural constituent of ribosome//chaperone binding//unfolded protein binding//adenyl-nucleotide exchange factor activity//phosphatase activity//RNA polymerase II transcription cofactor activity//metal ion binding//protein homodimerization activity GO:0005840//GO:0005622//GO:0044599//GO:0016592 ribosome//intracellular//AP-5 adaptor complex//mediator complex -- -- Cluster-8309.33885 BF_2 1375.01 18.41 3412 91080457 XP_969840.1 2275 3.5e-253 PREDICTED: TBC1 domain family member 15 [Tribolium castaneum]>gi|270005762|gb|EFA02210.1| hypothetical protein TcasGA2_TC007868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CXF4 1015 1.8e-108 TBC1 domain family member 15 OS=Mus musculus GN=Tbc1d15 PE=1 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.33886 BF_2 12.00 15.18 306 568599614 AHE13802.1 265 3.7e-21 chemosensory protein 6 [Lissorhoptrus oryzophilus] -- -- -- -- -- -- -- -- -- Q9W1C9 211 2.8e-16 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33887 BF_2 130.13 0.73 7795 546673544 ERL85123.1 3649 0.0e+00 hypothetical protein D910_02545 [Dendroctonus ponderosae] 156845530 XM_001645606.1 61 4.37497e-20 Vanderwaltozyma polyspora DSM 70294 hypothetical protein (Kpol_541p40) partial mRNA K12618 XRN1, SEP1, KEM1 5'-3' exoribonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12618 P97789 2567 4.6e-288 5'-3' exoribonuclease 1 OS=Mus musculus GN=Xrn1 PE=1 SV=1 PF03159//PF04117 XRN 5'-3' exonuclease N-terminus//Mpv17 / PMP22 family -- -- GO:0004527//GO:0003676 exonuclease activity//nucleic acid binding GO:0016021 integral component of membrane KOG2044 5'-3' exonuclease HKE1/RAT1 Cluster-8309.33888 BF_2 107.05 1.98 2547 478252680 ENN73076.1 265 3.1e-20 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3389 BF_2 16.05 0.92 1018 642919879 XP_973964.2 335 9.4e-29 PREDICTED: ganglioside GM2 activator [Tribolium castaneum] -- -- -- -- -- K12383 GM2A ganglioside GM2 activator http://www.genome.jp/dbget-bin/www_bget?ko:K12383 Q8HXX6 174 1.8e-11 Ganglioside GM2 activator OS=Macaca fascicularis GN=GM2A PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33890 BF_2 597.00 19.14 1592 642910713 XP_008200528.1 734 8.0e-75 PREDICTED: serine-arginine protein 55-like isoform X1 [Tribolium castaneum] 462281002 APGK01057804.1 120 1.39916e-53 Dendroctonus ponderosae Seq01057814, whole genome shotgun sequence K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 629 4.9e-64 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367//PF11744//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Aluminium activated malate transporter//RNA binding motif GO:0015743 malate transport GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.33891 BF_2 105.93 1.61 3032 478250426 ENN70921.1 505 5.4e-48 hypothetical protein YQE_12323, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BLW3 163 1.0e-09 Leucine-rich repeat-containing G-protein coupled receptor 4 OS=Xenopus tropicalis GN=lgr4 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.33892 BF_2 676.00 18.42 1822 642914825 XP_008194954.1 756 2.6e-77 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 Q8VI78 354 4.3e-32 Phospholipase A1 member A OS=Mus musculus GN=Pla1a PE=2 SV=3 PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.33893 BF_2 606.00 66.39 669 288860140 NP_001165842.1 181 4.5e-11 uracil-DNA degrading factor [Tribolium castaneum]>gi|270002992|gb|EEZ99439.1| hypothetical protein TcasGA2_TC030651 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05470//PF06213//PF01080//PF02724//PF03985 Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Cobalamin biosynthesis protein CobT//Presenilin//CDC45-like protein//Paf1 GO:0006368//GO:0006446//GO:0006270//GO:0009236//GO:0006413//GO:0016570 transcription elongation from RNA polymerase II promoter//regulation of translational initiation//DNA replication initiation//cobalamin biosynthetic process//translational initiation//histone modification GO:0004190//GO:0003743//GO:0031369 aspartic-type endopeptidase activity//translation initiation factor activity//translation initiation factor binding GO:0016593//GO:0016021//GO:0005852//GO:0005840 Cdc73/Paf1 complex//integral component of membrane//eukaryotic translation initiation factor 3 complex//ribosome -- -- Cluster-8309.33895 BF_2 69.23 1.96 1768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33896 BF_2 36.56 0.70 2459 642929787 XP_008195976.1 428 3.7e-39 PREDICTED: elongation of very long chain fatty acids protein AAEL008004-like [Tribolium castaneum]>gi|270009529|gb|EFA05977.1| hypothetical protein TcasGA2_TC008803 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 353 7.7e-32 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33899 BF_2 1285.13 11.25 5065 546681087 ERL91243.1 3068 0.0e+00 hypothetical protein D910_08578 [Dendroctonus ponderosae] -- -- -- -- -- K16685 WWC1 protein KIBRA http://www.genome.jp/dbget-bin/www_bget?ko:K16685 B4K6I9 1037 7.7e-111 Protein kibra OS=Drosophila mojavensis GN=Kibra PE=3 SV=1 PF05180//PF01253//PF00397//PF00168 DNL zinc finger//Translation initiation factor SUI1//WW domain//C2 domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0008270//GO:0003743//GO:0005515 zinc ion binding//translation initiation factor activity//protein binding GO:0005840 ribosome -- -- Cluster-8309.3390 BF_2 27.54 1.40 1109 642919879 XP_973964.2 335 1.0e-28 PREDICTED: ganglioside GM2 activator [Tribolium castaneum] -- -- -- -- -- K12383 GM2A ganglioside GM2 activator http://www.genome.jp/dbget-bin/www_bget?ko:K12383 Q8HXX6 174 2.0e-11 Ganglioside GM2 activator OS=Macaca fascicularis GN=GM2A PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33901 BF_2 397.73 3.33 5287 642925611 XP_008194640.1 2652 1.0e-296 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 2.3e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33903 BF_2 3335.23 66.60 2382 91080995 XP_975051.1 1985 1.0e-219 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 731415861 XM_010661396.1 41 1.7376e-09 PREDICTED: Vitis vinifera calreticulin (LOC100256319), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P27824 1374 3.0e-150 Calnexin OS=Homo sapiens GN=CANX PE=1 SV=2 PF13965//PF03348//PF02535//PF03896//PF05699//PF00262 dsRNA-gated channel SID-1//Serine incorporator (Serinc)//ZIP Zinc transporter//Translocon-associated protein (TRAP), alpha subunit//hAT family C-terminal dimerisation region//Calreticulin family GO:0033227//GO:0015931//GO:0030001//GO:0006457//GO:0055085 dsRNA transport//nucleobase-containing compound transport//metal ion transport//protein folding//transmembrane transport GO:0005509//GO:0051082//GO:0051033//GO:0046873//GO:0046983 calcium ion binding//unfolded protein binding//RNA transmembrane transporter activity//metal ion transmembrane transporter activity//protein dimerization activity GO:0016020//GO:0016021//GO:0005789//GO:0005783 membrane//integral component of membrane//endoplasmic reticulum membrane//endoplasmic reticulum KOG0675 Calnexin Cluster-8309.33904 BF_2 64.93 1.25 2464 91080995 XP_975051.1 1067 3.0e-113 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 641647106 XM_003240040.2 39 2.32626e-08 PREDICTED: Acyrthosiphon pisum calreticulin-like (LOC100161399), mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 Q5R440 738 1.7e-76 Calnexin OS=Pongo abelii GN=CANX PE=2 SV=2 PF00262//PF02535//PF02487//PF07850//PF13965//PF01080//PF04147//PF05699//PF02932//PF03348 Calreticulin family//ZIP Zinc transporter//CLN3 protein//Renin receptor-like protein//dsRNA-gated channel SID-1//Presenilin//Nop14-like family//hAT family C-terminal dimerisation region//Neurotransmitter-gated ion-channel transmembrane region//Serine incorporator (Serinc) GO:0033227//GO:0055085//GO:0015931//GO:0007165//GO:0006811//GO:0006457//GO:0030001 dsRNA transport//transmembrane transport//nucleobase-containing compound transport//signal transduction//ion transport//protein folding//metal ion transport GO:0051082//GO:0051033//GO:0046873//GO:0005509//GO:0004872//GO:0046983//GO:0004190 unfolded protein binding//RNA transmembrane transporter activity//metal ion transmembrane transporter activity//calcium ion binding//receptor activity//protein dimerization activity//aspartic-type endopeptidase activity GO:0032040//GO:0016021//GO:0016020//GO:0005783 small-subunit processome//integral component of membrane//membrane//endoplasmic reticulum KOG0675 Calnexin Cluster-8309.33905 BF_2 23.25 0.47 2367 91080995 XP_975051.1 1818 2.4e-200 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 731415861 XM_010661396.1 41 1.72649e-09 PREDICTED: Vitis vinifera calreticulin (LOC100256319), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P35565 1345 6.9e-147 Calnexin OS=Rattus norvegicus GN=Canx PE=1 SV=1 PF02487//PF03896//PF02535//PF00262//PF01080 CLN3 protein//Translocon-associated protein (TRAP), alpha subunit//ZIP Zinc transporter//Calreticulin family//Presenilin GO:0030001//GO:0055085//GO:0006457 metal ion transport//transmembrane transport//protein folding GO:0004190//GO:0005488//GO:0051082//GO:0005509//GO:0046873 aspartic-type endopeptidase activity//binding//unfolded protein binding//calcium ion binding//metal ion transmembrane transporter activity GO:0016021//GO:0005789//GO:0005783//GO:0016020 integral component of membrane//endoplasmic reticulum membrane//endoplasmic reticulum//membrane KOG0675 Calnexin Cluster-8309.33906 BF_2 62.58 0.68 4130 478255030 ENN75262.1 1413 3.8e-153 hypothetical protein YQE_08178, partial [Dendroctonus ponderosae]>gi|546673318|gb|ERL84946.1| hypothetical protein D910_02369 [Dendroctonus ponderosae] 663266156 XM_008495200.1 48 3.89197e-13 PREDICTED: Calypte anna p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), mRNA K04409 PAK1 p21-activated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04409 Q29502 862 1.2e-90 Serine/threonine-protein kinase PAK 2 OS=Oryctolagus cuniculus GN=PAK2 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.33907 BF_2 697.42 9.25 3442 478255030 ENN75262.1 1806 8.6e-199 hypothetical protein YQE_08178, partial [Dendroctonus ponderosae]>gi|546673318|gb|ERL84946.1| hypothetical protein D910_02369 [Dendroctonus ponderosae] 663266156 XM_008495200.1 48 3.23792e-13 PREDICTED: Calypte anna p21 protein (Cdc42/Rac)-activated kinase 1 (PAK1), mRNA K04409 PAK1 p21-activated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04409 P35465 928 2.3e-98 Serine/threonine-protein kinase PAK 1 OS=Rattus norvegicus GN=Pak1 PE=1 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.33908 BF_2 1005.25 2.98 14380 189237595 XP_966729.2 2234 8.4e-248 PREDICTED: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [Tribolium castaneum] 642910997 XM_008195279.1 320 8.52233e-164 PREDICTED: Tribolium castaneum single-stranded DNA-binding protein 3 (LOC662190), transcript variant X4, mRNA K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 P49071 1432 3.4e-156 MAP kinase-activated protein kinase 2 OS=Drosophila melanogaster GN=MAPk-Ak2 PE=2 SV=1 PF00069//PF09029//PF07714//PF06293//PF01212//PF01053//PF00155//PF08001//PF06016 Protein kinase domain//5-aminolevulinate synthase presequence//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II//CMV US//Reovirus core-spike protein lambda-2 (L2) GO:0006520//GO:0006544//GO:0006783//GO:0030683//GO:0009451//GO:0006370//GO:0009058//GO:0006566//GO:0006778//GO:0042967//GO:0006468//GO:0006563 cellular amino acid metabolic process//glycine metabolic process//heme biosynthetic process//evasion or tolerance by virus of host immune response//RNA modification//7-methylguanosine mRNA capping//biosynthetic process//threonine metabolic process//porphyrin-containing compound metabolic process//acyl-carrier-protein biosynthetic process//protein phosphorylation//L-serine metabolic process GO:0004672//GO:0016773//GO:0004484//GO:0003870//GO:0030170//GO:0004482//GO:0016829//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//mRNA guanylyltransferase activity//5-aminolevulinate synthase activity//pyridoxal phosphate binding//mRNA (guanine-N7-)-methyltransferase activity//lyase activity//ATP binding GO:0005759//GO:0016020//GO:0044386//GO:0019028 mitochondrial matrix//membrane//integral to host endoplasmic reticulum membrane//viral capsid KOG0604 MAP kinase-activated protein kinase 2 Cluster-8309.33910 BF_2 31.77 0.54 2764 443707618 ELU03131.1 1019 1.2e-107 hypothetical protein CAPTEDRAFT_198317 [Capitella teleta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 935 2.8e-99 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF01842//PF13465//PF00096//PF16622//PF13912 ACT domain//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger GO:0008152 metabolic process GO:0016597//GO:0046872 amino acid binding//metal ion binding -- -- -- -- Cluster-8309.33912 BF_2 452.00 25.80 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33913 BF_2 114.39 1.03 4936 546685733 ERL95188.1 972 6.3e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 4.2e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF13639//PF14634 Ring finger domain//zinc-RING finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.33914 BF_2 461.37 25.43 1046 91082539 XP_973726.1 660 2.0e-66 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 1.6e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.33915 BF_2 629.04 12.93 2322 332377013 AEE63646.1 1104 1.5e-117 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VD07 261 3.4e-21 Neuronal membrane glycoprotein M6-a OS=Bos taurus GN=GPM6A PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33916 BF_2 206.40 3.37 2851 642933386 XP_008197395.1 2403 4.2e-268 PREDICTED: HEAT repeat-containing protein 2 [Tribolium castaneum]>gi|270011379|gb|EFA07827.1| hypothetical protein TcasGA2_TC005396 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q86Y56 978 3.0e-104 Dynein assembly factor 5, axonemal OS=Homo sapiens GN=DNAAF5 PE=1 SV=4 PF11640//PF02985 Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0005515 protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.33919 BF_2 1066.86 20.56 2458 91087167 XP_975374.1 1359 4.2e-147 PREDICTED: putative deoxyribonuclease TATDN1 [Tribolium castaneum]>gi|270010559|gb|EFA07007.1| hypothetical protein TcasGA2_TC009977 [Tribolium castaneum] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 Q9L6M2 559 1.0e-55 Tat-linked quality control protein TatD OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) GN=tatD PE=3 SV=1 PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3020 TatD-related DNase Cluster-8309.33920 BF_2 530.49 8.11 3023 642918838 XP_008191608.1 2515 4.6e-281 PREDICTED: breast carcinoma-amplified sequence 3 homolog isoform X1 [Tribolium castaneum] 642918839 XM_008193387.1 255 2.41319e-128 PREDICTED: Tribolium castaneum breast carcinoma-amplified sequence 3 homolog (LOC661755), transcript variant X2, mRNA -- -- -- -- Q8SY41 1526 9.1e-168 Breast carcinoma-amplified sequence 3 homolog OS=Drosophila melanogaster GN=rudhira PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2109 WD40 repeat protein Cluster-8309.33921 BF_2 3626.29 89.45 1983 642930944 XP_008196151.1 1847 8.7e-204 PREDICTED: protein diaphanous isoform X1 [Tribolium castaneum] -- -- -- -- -- K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 1365 2.8e-149 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF08586//PF11744//PF01207 RSC complex, Rsc14/Ldb7 subunit//Aluminium activated malate transporter//Dihydrouridine synthase (Dus) GO:0015743//GO:0055114//GO:0043044//GO:0008033 malate transport//oxidation-reduction process//ATP-dependent chromatin remodeling//tRNA processing GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding GO:0016586 RSC complex KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.33922 BF_2 3706.70 85.30 2105 478260742 ENN80421.1 1508 1.9e-164 hypothetical protein YQE_03169, partial [Dendroctonus ponderosae] 642930947 XM_008197931.1 56 7.02996e-18 PREDICTED: Tribolium castaneum protein diaphanous (LOC660495), transcript variant X3, mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 749 7.9e-78 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF06367//PF06371//PF10508 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain//Proteasome non-ATPase 26S subunit GO:0043248//GO:0016043//GO:0030036 proteasome assembly//cellular component organization//actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1924 RhoA GTPase effector DIA/Diaphanous Cluster-8309.33924 BF_2 2308.00 196.30 779 189234669 XP_001810780.1 281 1.3e-22 PREDICTED: uncharacterized protein LOC100141906 [Tribolium castaneum]>gi|270001601|gb|EEZ98048.1| hypothetical protein TcasGA2_TC000453 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33925 BF_2 31.40 0.31 4488 478252177 ENN72605.1 1192 1.8e-127 hypothetical protein YQE_10705, partial [Dendroctonus ponderosae] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1066 2.9e-114 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF01566 Natural resistance-associated macrophage protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.33927 BF_2 23.00 2.26 712 170321839 BAG14264.1 488 1.2e-46 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P28175 274 3.2e-23 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.33928 BF_2 1.00 24.70 212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33930 BF_2 2070.57 64.60 1628 270010243 EFA06691.1 735 6.3e-75 hypothetical protein TcasGA2_TC009622 [Tribolium castaneum] -- -- -- -- -- K09250 CNBP cellular nucleic acid-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09250 Q8T8R1 419 1.1e-39 CCHC-type zinc finger protein CG3800 OS=Drosophila melanogaster GN=CG3800 PE=1 SV=1 PF00098//PF05733 Zinc knuckle//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0003676//GO:0003723//GO:0008270 nucleic acid binding//RNA binding//zinc ion binding GO:0019013 viral nucleocapsid KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.33933 BF_2 381.51 8.68 2125 642923845 XP_008193902.1 1333 3.7e-144 PREDICTED: uncharacterized protein LOC662374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82198 175 2.9e-11 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus GN=Tgfbi PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33935 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33936 BF_2 716.97 4.94 6358 478251817 ENN72263.1 1263 1.5e-135 hypothetical protein YQE_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 528 1.0e-51 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF02654 Sugar (and other) transporter//Major Facilitator Superfamily//Cobalamin-5-phosphate synthase GO:0055085//GO:0009236 transmembrane transport//cobalamin biosynthetic process GO:0008818//GO:0022857//GO:0051073 cobalamin 5'-phosphate synthase activity//transmembrane transporter activity//adenosylcobinamide-GDP ribazoletransferase activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33937 BF_2 205.97 1.22 7323 478251817 ENN72263.1 1262 2.2e-135 hypothetical protein YQE_11124, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 528 1.2e-51 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF02654//PF00083//PF07690 Cobalamin-5-phosphate synthase//Sugar (and other) transporter//Major Facilitator Superfamily GO:0009236//GO:0055085 cobalamin biosynthetic process//transmembrane transport GO:0008818//GO:0022857//GO:0051073 cobalamin 5'-phosphate synthase activity//transmembrane transporter activity//adenosylcobinamide-GDP ribazoletransferase activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.33939 BF_2 1437.47 9.26 6783 642911031 XP_008193516.1 1571 3.0e-171 PREDICTED: cytoplasmic polyadenylation element-binding protein 2 [Tribolium castaneum] 462332955 APGK01039143.1 249 1.17936e-124 Dendroctonus ponderosae Seq01039153, whole genome shotgun sequence K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q9VSR3 737 6.3e-76 Probable RNA-binding protein orb2 OS=Drosophila melanogaster GN=orb2 PE=1 SV=1 PF00643//PF16367//PF00076 B-box zinc finger//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.33940 BF_2 2638.99 102.71 1362 642935173 XP_008199677.1 518 7.6e-50 PREDICTED: elongation of very long chain fatty acids protein 7 [Tribolium castaneum]>gi|270014194|gb|EFA10642.1| hypothetical protein TcasGA2_TC016279 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1HRV8 330 2.0e-29 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.33941 BF_2 4382.16 154.98 1470 546680237 ERL90555.1 405 1.0e-36 hypothetical protein D910_07903 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P47948 208 3.0e-15 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF07645//PF13833//PF00036//PF13405//PF13499//PF13202//PF12763 Calcium-binding EGF domain//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.33942 BF_2 298.08 3.98 3424 642938815 XP_008199930.1 763 7.5e-78 PREDICTED: uncharacterized protein LOC103314794 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.33943 BF_2 1002.15 18.20 2590 91081545 XP_974976.1 1293 2.0e-139 PREDICTED: calumenin [Tribolium castaneum]>gi|270006175|gb|EFA02623.1| hypothetical protein TcasGA2_TC008343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDD8 880 6.3e-93 Calumenin OS=Pongo abelii GN=CALU PE=2 SV=1 PF13202//PF13499//PF08707//PF10591//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//Primase C terminal 2 (PriCT-2)//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.33944 BF_2 12.95 1.18 747 332376226 AEE63253.1 882 2.6e-92 unknown [Dendroctonus ponderosae] 780649516 XM_011691731.1 82 8.5288e-33 PREDICTED: Wasmannia auropunctata arrestin homolog (LOC105451355), mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P32122 795 1.3e-83 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.33945 BF_2 8.00 0.34 1262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33947 BF_2 1386.00 77.22 1038 189237685 XP_969117.2 1150 3.0e-123 PREDICTED: proteasome subunit alpha type-7-1 [Tribolium castaneum]>gi|270007836|gb|EFA04284.1| hypothetical protein TcasGA2_TC014574 [Tribolium castaneum] 817185130 XM_012429758.1 219 8.34933e-109 PREDICTED: Orussus abietinus proteasome subunit alpha type-7 (LOC105702287), mRNA K02731 PSMA7 20S proteasome subunit alpha 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02731 P22769 985 1.7e-105 Proteasome subunit alpha type-7-1 OS=Drosophila melanogaster GN=Prosalpha4 PE=1 SV=2 PF10584//PF00227 Proteasome subunit A N-terminal signature//Proteasome subunit GO:0006511//GO:0051603 ubiquitin-dependent protein catabolic process//proteolysis involved in cellular protein catabolic process GO:0004175//GO:0004298 endopeptidase activity//threonine-type endopeptidase activity GO:0005634//GO:0005839//GO:0019773//GO:0005737 nucleus//proteasome core complex//proteasome core complex, alpha-subunit complex//cytoplasm KOG0183 20S proteasome, regulatory subunit alpha type PSMA7/PRE6 Cluster-8309.33948 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33949 BF_2 2088.00 47.53 2125 478263440 ENN81801.1 2031 4.3e-225 hypothetical protein YQE_01807, partial [Dendroctonus ponderosae] 642913020 XM_008203132.1 388 0 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase pitchoune (LOC662696), mRNA K13179 DDX18, HAS1 ATP-dependent RNA helicase DDX18/HAS1 http://www.genome.jp/dbget-bin/www_bget?ko:K13179 Q9VD51 1856 3.5e-206 Probable ATP-dependent RNA helicase pitchoune OS=Drosophila melanogaster GN=pit PE=2 SV=2 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding -- -- KOG0342 ATP-dependent RNA helicase pitchoune Cluster-8309.33950 BF_2 1719.95 14.48 5256 642927920 XP_008195448.1 2122 3.0e-235 PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927922|ref|XP_008195449.1| PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927924|ref|XP_974516.2| PREDICTED: dystroglycan [Tribolium castaneum] 642927923 XM_969423.3 68 3.78228e-24 PREDICTED: Tribolium castaneum dystroglycan (LOC663372), transcript variant X3, mRNA K06265 DAG1 dystroglycan 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06265 Q9TSZ6 506 3.0e-49 Dystroglycan OS=Canis familiaris GN=DAG1 PE=3 SV=1 PF03176//PF05454 MMPL family//Dystroglycan (Dystrophin-associated glycoprotein 1) GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016020//GO:0016010 membrane//dystrophin-associated glycoprotein complex KOG3781 Dystroglycan Cluster-8309.33951 BF_2 133.74 0.60 9565 642930211 XP_008196303.1 2766 1.1e-309 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.47584e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1682 2.3e-185 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF07859//PF09494//PF15384//PF01764//PF02186//PF02170//PF02230//PF02171//PF04636 alpha/beta hydrolase fold//Slx4 endonuclease//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//Lipase (class 3)//TFIIE beta subunit core domain//PAZ domain//Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin) GO:0006308//GO:1901031//GO:0006367//GO:0006260//GO:0006629//GO:0006281//GO:0006303//GO:0008152 DNA catabolic process//regulation of response to reactive oxygen species//transcription initiation from RNA polymerase II promoter//DNA replication//lipid metabolic process//DNA repair//double-strand break repair via nonhomologous end joining//metabolic process GO:0003676//GO:0005515//GO:0017108//GO:0016787 nucleic acid binding//protein binding//5'-flap endonuclease activity//hydrolase activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.33952 BF_2 178.63 1.98 4063 642933496 XP_974029.2 2621 3.2e-293 PREDICTED: rho GTPase-activating protein 20-like isoform X1 [Tribolium castaneum]>gi|642933498|ref|XP_008197442.1| PREDICTED: rho GTPase-activating protein 20-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2F6 386 1.9e-35 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00788//PF00620 Ras association (RalGDS/AF-6) domain//RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.33953 BF_2 206.00 4.61 2155 642914709 XP_008199908.1 364 8.7e-32 PREDICTED: protein slit-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 180 7.7e-12 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF04159//PF13855//PF00560 NB glycoprotein//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.33954 BF_2 1935.11 38.74 2377 642931392 XP_008196559.1 1015 3.1e-107 PREDICTED: paramyosin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33959 BF_2 517.36 9.40 2590 91082539 XP_973726.1 2206 2.7e-245 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 839 3.6e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF03357//PF08496//PF06905//PF11965 Snf7//Peptidase family S49 N-terminal//Fas apoptotic inhibitory molecule (FAIM1)//Domain of unknown function (DUF3479) GO:0015994//GO:0007034//GO:0043066 chlorophyll metabolic process//vacuolar transport//negative regulation of apoptotic process GO:0016851//GO:0004252 magnesium chelatase activity//serine-type endopeptidase activity GO:0005886//GO:0010007 plasma membrane//magnesium chelatase complex -- -- Cluster-8309.33960 BF_2 83.19 1.31 2936 642915507 XP_008190646.1 500 2.0e-47 PREDICTED: suppressor of cytokine signaling 6 [Tribolium castaneum]>gi|270004015|gb|EFA00463.1| hypothetical protein TcasGA2_TC003320 [Tribolium castaneum] -- -- -- -- -- K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q9JLY0 390 4.7e-36 Suppressor of cytokine signaling 6 OS=Mus musculus GN=Socs6 PE=1 SV=2 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.33961 BF_2 75.98 0.71 4752 642918534 XP_008191512.1 3217 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7P4 637 1.7e-64 SEC14 domain and spectrin repeat-containing protein 1 OS=Xenopus tropicalis GN=sestd1 PE=2 SV=1 PF00435//PF00260//PF00536 Spectrin repeat//Protamine P1//SAM domain (Sterile alpha motif) GO:0007283 spermatogenesis GO:0003677//GO:0005515 DNA binding//protein binding GO:0000786//GO:0005634 nucleosome//nucleus KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.33963 BF_2 249.00 5.56 2162 642938245 XP_008198127.1 1026 1.5e-108 PREDICTED: chromatin assembly factor 1 subunit A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JMK9 309 8.5e-27 Chromatin assembly factor 1 subunit A OS=Danio rerio GN=chaf1a PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4364 Chromatin assembly factor-I Cluster-8309.33964 BF_2 559.91 3.72 6591 642938247 XP_008198128.1 1652 1.2e-180 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 405 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 1386 3.4e-151 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF17096//PF02932//PF05445//PF06553//PF03293//PF07714//PF01080//PF00069 Altered inheritance of mitochondria protein 3//Neurotransmitter-gated ion-channel transmembrane region//Poxvirus serine/threonine protein kinase//BNIP3//Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Protein tyrosine kinase//Presenilin//Protein kinase domain GO:0006144//GO:0006351//GO:0006811//GO:0051016//GO:0006206//GO:0006468//GO:0019083//GO:0043065 purine nucleobase metabolic process//transcription, DNA-templated//ion transport//barbed-end actin filament capping//pyrimidine nucleobase metabolic process//protein phosphorylation//viral transcription//positive regulation of apoptotic process GO:0004190//GO:0003677//GO:0004672//GO:0005524//GO:0003899 aspartic-type endopeptidase activity//DNA binding//protein kinase activity//ATP binding//DNA-directed RNA polymerase activity GO:0016020//GO:0030479//GO:0016021//GO:0005730//GO:0005740 membrane//actin cortical patch//integral component of membrane//nucleolus//mitochondrial envelope KOG0671 LAMMER dual specificity kinases Cluster-8309.33965 BF_2 184.61 1.77 4648 642926401 XP_008191947.1 3150 0.0e+00 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 635 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 1612 1.5e-177 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF03846//PF00105//PF00104 Cell division inhibitor SulA//Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0051782//GO:0006355//GO:0009432//GO:0007165 steroid hormone mediated signaling pathway//negative regulation of cell division//regulation of transcription, DNA-templated//SOS response//signal transduction GO:0043565//GO:0008270//GO:0003700//GO:0046872//GO:0003707 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//steroid hormone receptor activity GO:0005634//GO:0009276//GO:0005667 nucleus//Gram-negative-bacterium-type cell wall//transcription factor complex -- -- Cluster-8309.33966 BF_2 27.14 0.32 3815 571533289 XP_006561360.1 595 2.5e-58 PREDICTED: uncharacterized protein LOC725964 isoform X1 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88281 393 2.7e-36 Multiple epidermal growth factor-like domains protein 6 OS=Rattus norvegicus GN=Megf6 PE=1 SV=1 PF02793//PF07645 Hormone receptor domain//Calcium-binding EGF domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005509 G-protein coupled receptor activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.33967 BF_2 63.37 0.72 3961 270006563 EFA03011.1 2199 2.6e-244 hypothetical protein TcasGA2_TC010434 [Tribolium castaneum] 768439826 XM_011563263.1 40 1.04481e-08 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1104 1.0e-118 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304//PF00664//PF01637 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Archaeal ATPase GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.33968 BF_2 7.00 0.60 776 751233858 XP_011170631.1 330 2.7e-28 PREDICTED: uncharacterized protein LOC105203526 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33969 BF_2 2125.97 49.69 2077 642926440 XP_972024.2 378 2.0e-33 PREDICTED: eukaryotic translation initiation factor 4H [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WUK2 275 7.2e-23 Eukaryotic translation initiation factor 4H OS=Mus musculus GN=Eif4h PE=1 SV=3 PF00076//PF05432 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Bone sialoprotein II (BSP-II) GO:0001503//GO:0007155 ossification//cell adhesion GO:0003676 nucleic acid binding GO:0005576 extracellular region KOG0118 FOG: RRM domain Cluster-8309.3397 BF_2 63.39 1.66 1880 642933166 XP_008197284.1 1918 4.8e-212 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 680 7.1e-70 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- -- -- Cluster-8309.33970 BF_2 382.14 9.53 1964 478255591 ENN75805.1 2200 1.0e-244 hypothetical protein YQE_07641, partial [Dendroctonus ponderosae]>gi|546682293|gb|ERL92251.1| hypothetical protein D910_09568 [Dendroctonus ponderosae] 704290140 XM_010177591.1 138 1.70909e-63 PREDICTED: Caprimulgus carolinensis SNW domain containing 1 (SNW1), partial mRNA K06063 SNW1, SKIIP, SKIP SNW domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06063 P39736 1642 2.1e-181 Puff-specific protein Bx42 OS=Drosophila melanogaster GN=Bx42 PE=1 SV=1 PF02731//PF02841 SKIP/SNW domain//Guanylate-binding protein, C-terminal domain GO:0000398 mRNA splicing, via spliceosome GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005681 spliceosomal complex KOG2441 mRNA splicing factor/probable chromatin binding snw family nuclear protein Cluster-8309.33971 BF_2 32.24 0.85 1883 642936925 XP_008194485.1 875 4.2e-91 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 264 1.2e-21 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.33972 BF_2 4.00 0.63 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33973 BF_2 507.47 13.09 1909 478256415 ENN76602.1 1537 7.4e-168 hypothetical protein YQE_06860, partial [Dendroctonus ponderosae]>gi|546677585|gb|ERL88390.1| hypothetical protein D910_05776 [Dendroctonus ponderosae] -- -- -- -- -- K04427 MAP3K7, TAK1 mitogen-activated protein kinase kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04427 Q5RFL3 896 6.5e-95 Mitogen-activated protein kinase kinase kinase 7 OS=Pongo abelii GN=MAP3K7 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0192 Tyrosine kinase specific for activated (GTP-bound) p21cdc42Hs Cluster-8309.33974 BF_2 205.09 4.68 2122 642915291 XP_008190557.1 1402 3.7e-152 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 656 4.8e-67 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.33975 BF_2 868.00 44.73 1099 332374658 AEE62470.1 853 8.8e-89 unknown [Dendroctonus ponderosae]>gi|478259682|gb|ENN79526.1| hypothetical protein YQE_03989, partial [Dendroctonus ponderosae]>gi|546682953|gb|ERL92832.1| hypothetical protein D910_10140 [Dendroctonus ponderosae] 346708051 AK378343.1 163 1.19535e-77 Bombyx mori mRNA, clone: fmgV32H08 K12197 CHMP1, VPS46, DID2 charged multivesicular body protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12197 Q5ZKX1 645 4.7e-66 Charged multivesicular body protein 1b OS=Gallus gallus GN=CHMP1B PE=2 SV=1 PF13413//PF03357//PF00443 Helix-turn-helix domain//Snf7//Ubiquitin carboxyl-terminal hydrolase GO:0007034//GO:0016579 vacuolar transport//protein deubiquitination GO:0036459//GO:0003677 ubiquitinyl hydrolase activity//DNA binding -- -- KOG3232 Vacuolar assembly/sorting protein DID2 Cluster-8309.33976 BF_2 236.32 11.21 1169 158562474 ABW74143.1 489 1.5e-46 cuticular protein Ld-CP3 [Leptinotarsa decemlineata] 766935802 XM_011501981.1 36 5.05283e-07 PREDICTED: Ceratosolen solmsi marchali endocuticle structural glycoprotein SgAbd-8-like (LOC105364117), mRNA -- -- -- -- Q7M4F3 319 3.2e-28 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.33978 BF_2 1359.03 20.36 3079 642932474 XP_008197131.1 1327 2.7e-143 PREDICTED: uncharacterized protein LOC662025 isoform X1 [Tribolium castaneum] 642932473 XM_008198909.1 261 1.13573e-131 PREDICTED: Tribolium castaneum uncharacterized LOC662025 (LOC662025), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33979 BF_2 75.64 3.10 1307 189239912 XP_971042.2 392 3.0e-35 PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|642931218|ref|XP_008196488.1| PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|270012116|gb|EFA08564.1| hypothetical protein TcasGA2_TC006219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQT7 256 7.2e-21 Desumoylating isopeptidase 1 OS=Mus musculus GN=Desi1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.33980 BF_2 570.00 19.55 1507 478256232 ENN76426.1 1870 1.4e-206 hypothetical protein YQE_07087, partial [Dendroctonus ponderosae]>gi|478268074|gb|ENN83141.1| hypothetical protein YQE_00495, partial [Dendroctonus ponderosae]>gi|546684450|gb|ERL94089.1| hypothetical protein D910_11371 [Dendroctonus ponderosae] -- -- -- -- -- K16575 ACTR1, ARP1 centractin http://www.genome.jp/dbget-bin/www_bget?ko:K16575 Q8R5C5 1676 1.8e-185 Beta-centractin OS=Mus musculus GN=Actr1b PE=1 SV=1 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.33982 BF_2 2324.00 126.78 1054 91077414 XP_975386.1 1035 6.6e-110 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 551522690 XM_005812776.1 214 5.10508e-106 PREDICTED: Xiphophorus maculatus stress-70 protein, mitochondrial-like (LOC102235937), mRNA K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 Q5ZM98 945 7.4e-101 Stress-70 protein, mitochondrial OS=Gallus gallus GN=HSPA9 PE=1 SV=1 -- -- GO:0006457 protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding -- -- KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.33983 BF_2 1305.85 30.52 2077 755943442 XP_011299119.1 935 5.1e-98 PREDICTED: 14-3-3 protein zeta isoform X2 [Fopius arisanus] 642911747 XM_008202503.1 179 2.92223e-86 PREDICTED: Tribolium castaneum 14-3-3 protein zeta (LOC660150), mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 878 8.6e-93 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF05823//PF02154 Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Flagellar motor switch protein FliM GO:0071973 bacterial-type flagellum-dependent cell motility GO:0008289//GO:0003774 lipid binding//motor activity GO:0009425 bacterial-type flagellum basal body -- -- Cluster-8309.33984 BF_2 314.12 13.20 1283 642923427 XP_008193740.1 1291 1.7e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUQ0 385 7.8e-36 Clavesin-1 OS=Homo sapiens GN=CLVS1 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.33985 BF_2 767.57 27.35 1461 642939156 XP_008200359.1 1798 3.1e-198 PREDICTED: host cell factor 2 isoform X1 [Tribolium castaneum] 642939157 XM_964209.2 291 1.12027e-148 PREDICTED: Tribolium castaneum host cell factor 2 (LOC657767), transcript variant X2, mRNA K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q61191 1463 8.8e-161 Host cell factor 1 OS=Mus musculus GN=Hcfc1 PE=1 SV=2 PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.33987 BF_2 474.87 6.23 3474 91094425 XP_969302.1 2010 1.9e-222 PREDICTED: host cell factor 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q9V4C8 647 8.8e-66 Host cell factor OS=Drosophila melanogaster GN=Hcf PE=1 SV=2 PF11722//PF00041//PF16656 CCCH zinc finger in TRM13 protein//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0008168//GO:0003993//GO:0046872//GO:0005515 methyltransferase activity//acid phosphatase activity//metal ion binding//protein binding -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.33993 BF_2 5145.22 62.92 3708 91094023 XP_967468.1 757 4.0e-77 PREDICTED: protein BTG1-like [Tribolium castaneum] 642915766 XM_962375.2 127 4.23708e-57 PREDICTED: Tribolium castaneum protein BTG1-like (LOC655815), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 P50615 292 1.4e-24 Protein BTG3 OS=Mus musculus GN=Btg3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.33995 BF_2 5.57 0.94 536 642922790 XP_008193326.1 171 5.2e-10 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33996 BF_2 1378.99 32.10 2084 642933476 XP_008197433.1 1033 2.2e-109 PREDICTED: cytochrome P450 9e2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q964T2 774 9.9e-81 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.33998 BF_2 389.00 38.67 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.33999 BF_2 152.23 0.80 8263 156481746 ABU68466.1 2057 1.6e-227 laccase 2 [Monochamus alternatus] 156481745 EU093075.1 794 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 5.0e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF07732//PF00394//PF07731 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0016491//GO:0005507 oxidoreductase activity//copper ion binding -- -- KOG1263 Multicopper oxidases Cluster-8309.34000 BF_2 656.04 3.69 7734 156481746 ABU68466.1 2057 1.5e-227 laccase 2 [Monochamus alternatus] 156481745 EU093075.1 794 0 Monochamus alternatus laccase 2 mRNA, complete cds -- -- -- -- Q99056 454 4.7e-43 Laccase-5 OS=Trametes villosa GN=LCC5 PE=3 SV=2 PF07731//PF00394//PF07732 Multicopper oxidase//Multicopper oxidase//Multicopper oxidase GO:0055114 oxidation-reduction process GO:0005507//GO:0016491 copper ion binding//oxidoreductase activity -- -- KOG1263 Multicopper oxidases Cluster-8309.34002 BF_2 120.38 5.90 1141 820805582 AKG92782.1 561 6.6e-55 Pxs [Leptinotarsa decemlineata] 543263651 XM_005422191.1 85 2.84613e-34 PREDICTED: Geospiza fortis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q60539 292 4.2e-25 Transcription factor 15 OS=Mesocricetus auratus GN=TCF15 PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.34004 BF_2 2079.34 30.69 3121 642912272 XP_008200632.1 945 5.3e-99 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 7.7e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089 Delta serrate ligand//Trypsin GO:0007154//GO:0006508 cell communication//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.34005 BF_2 3167.79 115.75 1432 751447415 XP_011177845.1 246 2.8e-18 PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751447417|ref|XP_011177846.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751797807|ref|XP_011208789.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera dorsalis] -- -- -- -- -- K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P00430 136 6.5e-07 Cytochrome c oxidase subunit 7C, mitochondrial OS=Bos taurus GN=COX7C PE=1 SV=3 PF02935 Cytochrome c oxidase subunit VIIc GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.34006 BF_2 81.60 2.00 1994 91085815 XP_974770.1 279 5.8e-22 PREDICTED: maternal protein exuperantia-1 [Tribolium castaneum]>gi|270011046|gb|EFA07494.1| exuperantia [Tribolium castaneum] -- -- -- -- -- K18745 EXU maternal protein exuperantia http://www.genome.jp/dbget-bin/www_bget?ko:K18745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34010 BF_2 26.86 0.32 3849 642929416 XP_008195830.1 1110 4.9e-118 PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929418|ref|XP_008195831.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929420|ref|XP_008195832.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI7 662 1.8e-67 Upstream-binding protein 1 OS=Homo sapiens GN=UBP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.34011 BF_2 1408.07 9.81 6293 189239910 XP_001811161.1 2656 4.3e-297 PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|642931213|ref|XP_008196486.1| PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|270012115|gb|EFA08563.1| hypothetical protein TcasGA2_TC006218 [Tribolium castaneum] 642931212 XM_008198264.1 80 9.67119e-31 PREDICTED: Tribolium castaneum uncharacterized LOC100142394 (LOC100142394), transcript variant X2, mRNA -- -- -- -- P91791 286 1.2e-23 Peptidyl-prolyl cis-trans isomerase OS=Hemicentrotus pulcherrimus PE=2 SV=1 PF00097//PF01363//PF00643//PF14634//PF13639//PF00160 Zinc finger, C3HC4 type (RING finger)//FYVE zinc finger//B-box zinc finger//zinc-RING finger domain//Ring finger domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0008270//GO:0003755//GO:0005515//GO:0046872 zinc ion binding//peptidyl-prolyl cis-trans isomerase activity//protein binding//metal ion binding GO:0005622 intracellular KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.34012 BF_2 515.50 10.49 2342 642938126 XP_969076.2 1038 6.6e-110 PREDICTED: inositol monophosphatase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 P20456 674 4.4e-69 Inositol monophosphatase 1 OS=Bos taurus GN=IMPA1 PE=1 SV=1 PF02399//PF00459 Origin of replication binding protein//Inositol monophosphatase family GO:0046854//GO:0006260 phosphatidylinositol phosphorylation//DNA replication GO:0003688//GO:0005524 DNA replication origin binding//ATP binding GO:0046809 replication compartment KOG2951 Inositol monophosphatase Cluster-8309.34013 BF_2 7.00 0.32 1204 646709975 KDR15614.1 1030 2.9e-109 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- K05631 AIP3, WWP3, BAIAP1 atrophin-1 interacting protein 3 (BAI1-associated protein 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05631 A1A5G4 560 3.7e-56 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 OS=Xenopus tropicalis GN=magi3 PE=2 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3209 WW domain-containing protein Cluster-8309.34014 BF_2 1724.03 48.74 1767 383855940 XP_003703468.1 637 1.6e-63 PREDICTED: trypsin 3A1-like isoform X3 [Megachile rotundata] -- -- -- -- -- -- -- -- -- Q27081 352 7.2e-32 Clotting factor B OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34015 BF_2 51.99 1.20 2103 817058472 XP_012250699.1 345 1.3e-29 PREDICTED: tryptase beta-2-like [Athalia rosae] -- -- -- -- -- -- -- -- -- Q402U7 215 6.6e-16 Serine protease 44 OS=Mus musculus GN=Prss44 PE=2 SV=1 PF00089//PF08118 Trypsin//Yeast mitochondrial distribution and morphology (MDM) proteins GO:0006508//GO:0007005 proteolysis//mitochondrion organization GO:0004252 serine-type endopeptidase activity GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.34017 BF_2 78.00 11.74 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34018 BF_2 936.77 6.81 6043 827549501 XP_012546855.1 724 4.4e-73 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.34020 BF_2 246.57 15.08 971 642928426 XP_971688.3 700 4.3e-71 PREDICTED: RRP15-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VFE6 418 8.8e-40 RRP15-like protein OS=Drosophila melanogaster GN=CG3817 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2974 Uncharacterized conserved protein Cluster-8309.34022 BF_2 26.00 3.86 569 -- -- -- -- -- 403311088 JX457150.1 551 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34023 BF_2 33.11 0.51 2999 91094851 XP_972051.1 2107 9.3e-234 PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating [Tribolium castaneum]>gi|270006577|gb|EFA03025.1| hypothetical protein TcasGA2_TC010448 [Tribolium castaneum] 808352053 KR024162.1 90 1.26498e-36 Drosophila melanogaster strain ZK398 ph-p-RA (ph-p) gene, partial sequence; CG3835 (CG3835) and Pgd (Pgd) genes, complete cds, alternatively spliced; bcn92-RA (bcn92) gene, complete cds; wapl (wapl) and Cyp4d1 (Cyp4d1) genes, complete cds, alternatively spliced; and CG3630-RD (CG3630) gene, partial sequence K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P41570 1725 7.6e-191 6-phosphogluconate dehydrogenase, decarboxylating OS=Ceratitis capitata GN=Pgd PE=2 SV=1 PF03446//PF14833//PF00393 NAD binding domain of 6-phosphogluconate dehydrogenase//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//6-phosphogluconate dehydrogenase, C-terminal domain GO:0006098//GO:0019521//GO:0055114 pentose-phosphate shunt//D-gluconate metabolic process//oxidation-reduction process GO:0004616//GO:0050661//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//NADP binding//NAD binding -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-8309.34024 BF_2 4693.97 64.81 3317 577754854 AHH86056.1 1979 7.2e-219 glycoside hydrolase family 31 [Phaedon cochleariae] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 875 3.1e-92 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.34027 BF_2 2849.99 29.07 4389 91080259 XP_973356.1 2901 0.0e+00 PREDICTED: TBC1 domain family member 23 [Tribolium castaneum]>gi|270005620|gb|EFA02068.1| hypothetical protein TcasGA2_TC007702 [Tribolium castaneum] 641791443 XM_005305637.2 106 2.37022e-45 PREDICTED: Chrysemys picta bellii chaperonin containing TCP1, subunit 4 (delta) (CCT4), mRNA K09496 CCT4 T-complex protein 1 subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K09496 Q9NB32 2088 9.0e-233 T-complex protein 1 subunit delta OS=Ochlerotatus triseriatus PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding GO:0005622 intracellular KOG0358 Chaperonin complex component, TCP-1 delta subunit (CCT4) Cluster-8309.34028 BF_2 110.96 1.13 4403 642932431 XP_008197110.1 2076 5.4e-230 PREDICTED: uncharacterized protein LOC100141760 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34030 BF_2 82.35 1.90 2104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34032 BF_2 16.00 0.74 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34033 BF_2 54.26 0.66 3733 270012487 EFA08935.1 2481 5.0e-277 hypothetical protein TcasGA2_TC006642 [Tribolium castaneum] 645037466 XM_008219044.1 217 3.97456e-107 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1544 9.2e-170 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF00520//PF02214 Ion transport protein//BTB/POZ domain GO:0051260//GO:0006811//GO:0055085 protein homooligomerization//ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.34034 BF_2 34.20 0.37 4192 642920771 XP_008192553.1 1321 1.8e-142 PREDICTED: spondin-1-like [Tribolium castaneum]>gi|270005186|gb|EFA01634.1| hypothetical protein TcasGA2_TC007204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 831 4.9e-87 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF08943//PF00957//PF08925 CsiD//Synaptobrevin//Domain of Unknown Function (DUF1907) GO:0016192 vesicle-mediated transport GO:0005506 iron ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3539 Spondins, extracellular matrix proteins Cluster-8309.34036 BF_2 248.54 0.56 18694 642929802 XP_008195983.1 15974 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X2 [Tribolium castaneum] 642929801 XM_008197761.1 2865 0 PREDICTED: Tribolium castaneum dynein heavy chain (LOC664489), transcript variant X2, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 14248 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF01695//PF07728//PF04111//PF05791//PF00004//PF02932//PF10473//PF01031//PF01580//PF07851//PF13851//PF00437//PF01496//PF05529//PF14943//PF07926//PF07168//PF03938//PF00910//PF06156//PF05073//PF06160//PF06008//PF05496//PF06009//PF12106//PF03028//PF06810//PF03767//PF00005//PF04513//PF08702 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Autophagy protein Apg6//Bacillus haemolytic enterotoxin (HBL)//ATPase family associated with various cellular activities (AAA)//Neurotransmitter-gated ion-channel transmembrane region//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Dynamin central region//FtsK/SpoIIIE family//TMPIT-like protein//Growth-arrest specific micro-tubule binding//Type II/IV secretion system protein//V-type ATPase 116kDa subunit family//B-cell receptor-associated protein 31-like//Mitochondrial ribosome subunit S26//TPR/MLP1/MLP2-like protein//Ureide permease//Outer membrane protein (OmpH-like)//RNA helicase//Protein of unknown function (DUF972)//Baculovirus P24 capsid protein//Septation ring formation regulator, EzrA//Laminin Domain I//Holliday junction DNA helicase ruvB N-terminus//Laminin Domain II//Colicin C terminal ribonuclease domain//Dynein heavy chain and region D6 of dynein motor//Phage minor structural protein GP20//HAD superfamily, subfamily IIIB (Acid phosphatase)//ABC transporter//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family GO:0007017//GO:0051252//GO:0007018//GO:0030334//GO:0007165//GO:0009405//GO:0006914//GO:0051258//GO:0006810//GO:0006281//GO:0006886//GO:0007155//GO:0030155//GO:0006811//GO:0071705//GO:0015991//GO:0006606//GO:0006260//GO:0015992//GO:0045995//GO:0019497//GO:0006310//GO:0030168//GO:0006771//GO:0048870//GO:0000921 microtubule-based process//regulation of RNA metabolic process//microtubule-based movement//regulation of cell migration//signal transduction//pathogenesis//autophagy//protein polymerization//transport//DNA repair//intracellular protein transport//cell adhesion//regulation of cell adhesion//ion transport//nitrogen compound transport//ATP hydrolysis coupled proton transport//protein import into nucleus//DNA replication//proton transport//regulation of embryonic development//hexachlorocyclohexane metabolic process//DNA recombination//platelet activation//riboflavin metabolic process//cell motility//septin ring assembly GO:0000166//GO:0015078//GO:0005198//GO:0004540//GO:0005525//GO:0042803//GO:0009378//GO:0003724//GO:0003723//GO:0003677//GO:0051082//GO:0003993//GO:0016887//GO:0005102//GO:0005524//GO:0045502//GO:0008134//GO:0030674//GO:0003777 nucleotide binding//hydrogen ion transmembrane transporter activity//structural molecule activity//ribonuclease activity//GTP binding//protein homodimerization activity//four-way junction helicase activity//RNA helicase activity//RNA binding//DNA binding//unfolded protein binding//acid phosphatase activity//ATPase activity//receptor binding//ATP binding//dynein binding//transcription factor binding//protein binding, bridging//microtubule motor activity GO:0016021//GO:0009379//GO:0031514//GO:0005940//GO:0016020//GO:0033179//GO:0005657//GO:0005763//GO:0005783//GO:0005874//GO:0019031//GO:0005577//GO:0019028//GO:0030286//GO:0005667 integral component of membrane//Holliday junction helicase complex//motile cilium//septin ring//membrane//proton-transporting V-type ATPase, V0 domain//replication fork//mitochondrial small ribosomal subunit//endoplasmic reticulum//microtubule//viral envelope//fibrinogen complex//viral capsid//dynein complex//transcription factor complex KOG3595 Dyneins, heavy chain Cluster-8309.34037 BF_2 1511.71 21.62 3212 642922300 XP_008193101.1 1010 1.6e-106 PREDICTED: LOW QUALITY PROTEIN: isovaleryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 779 4.0e-81 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF02771//PF02770//PF00441//PF02270 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Transcription initiation factor IIF, beta subunit GO:0006118//GO:0006367//GO:0055114//GO:0008152//GO:0006366 obsolete electron transport//transcription initiation from RNA polymerase II promoter//oxidation-reduction process//metabolic process//transcription from RNA polymerase II promoter GO:0050660//GO:0016627//GO:0003995 flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.34038 BF_2 19.63 0.42 2262 91081621 XP_966892.1 1282 3.2e-138 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O24145 747 1.5e-77 4-coumarate--CoA ligase 1 OS=Nicotiana tabacum GN=4CL1 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.34041 BF_2 708.23 32.14 1209 642936556 XP_008198483.1 150 3.2e-07 PREDICTED: uncharacterized protein LOC103314366 [Tribolium castaneum]>gi|270014136|gb|EFA10584.1| hypothetical protein TcasGA2_TC012840 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.34042 BF_2 1986.89 52.68 1931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34043 BF_2 75.20 1.78 2056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34044 BF_2 9.07 1.34 571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34045 BF_2 1904.68 36.48 2471 478255194 ENN75423.1 2734 1.5e-306 hypothetical protein YQE_07974, partial [Dendroctonus ponderosae] 759182915 XM_011381699.1 369 0 PREDICTED: Pteropus vampyrus protein phosphatase 2, regulatory subunit A, alpha (PPP2R1A), transcript variant X1, mRNA K03456 PPP2R1 serine/threonine-protein phosphatase 2A regulatory subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03456 Q76MZ3 2356 4.2e-264 Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform OS=Mus musculus GN=Ppp2r1a PE=1 SV=3 PF02985//PF01602 HEAT repeat//Adaptin N terminal region GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.34046 BF_2 72.69 1.20 2824 91077036 XP_967646.1 794 1.6e-81 PREDICTED: molybdenum cofactor sulfurase 1 [Tribolium castaneum]>gi|270001749|gb|EEZ98196.1| hypothetical protein TcasGA2_TC000626 [Tribolium castaneum] -- -- -- -- -- K15631 ABA3 molybdenum cofactor sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15631 Q8IU29 599 2.6e-60 Molybdenum cofactor sulfurase OS=Bombyx mori GN=mal PE=2 SV=1 PF01082//PF03473 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//MOSC domain GO:0055114 oxidation-reduction process GO:0003824//GO:0005507//GO:0030170//GO:0004497//GO:0016715//GO:0030151 catalytic activity//copper ion binding//pyridoxal phosphate binding//monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//molybdenum ion binding -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.34047 BF_2 528.97 7.56 3213 91077036 XP_967646.1 1648 1.7e-180 PREDICTED: molybdenum cofactor sulfurase 1 [Tribolium castaneum]>gi|270001749|gb|EEZ98196.1| hypothetical protein TcasGA2_TC000626 [Tribolium castaneum] -- -- -- -- -- K15631 ABA3 molybdenum cofactor sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15631 Q8IU29 1184 4.4e-128 Molybdenum cofactor sulfurase OS=Bombyx mori GN=mal PE=2 SV=1 PF01082//PF00779//PF03473 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//BTK motif//MOSC domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0016715//GO:0003824//GO:0005507//GO:0030170//GO:0004497//GO:0030151 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//catalytic activity//copper ion binding//pyridoxal phosphate binding//monooxygenase activity//molybdenum ion binding -- -- KOG2142 Molybdenum cofactor sulfurase Cluster-8309.34048 BF_2 45.39 0.49 4152 270015509 EFA11957.1 1503 1.4e-163 serine protease H82 [Tribolium castaneum] 641658676 XM_001951259.3 168 7.67122e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- Q96EN8 486 4.9e-47 Molybdenum cofactor sulfurase OS=Homo sapiens GN=MOCOS PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34049 BF_2 340.00 64.95 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34052 BF_2 26.11 0.76 1726 157133797 XP_001663018.1 389 8.7e-35 AAEL012859-PA [Aedes aegypti]>gi|108870713|gb|EAT34938.1| AAEL012859-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08445//PF13673//PF13508//PF00583 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-8309.34053 BF_2 1301.00 17.99 3312 642930597 XP_008198288.1 3539 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 35 isoform X1 [Tribolium castaneum] 874486365 XM_013103861.1 127 3.78014e-57 PREDICTED: Anas platyrhynchos VPS35 retromer complex component (VPS35), transcript variant X2, mRNA K18468 VPS35 vacuolar protein sorting-associated protein 35 http://www.genome.jp/dbget-bin/www_bget?ko:K18468 Q2HJG5 2694 3.6e-303 Vacuolar protein sorting-associated protein 35 OS=Bos taurus GN=VPS35 PE=2 SV=1 PF03635 Vacuolar protein sorting-associated protein 35 GO:0042147//GO:0015031 retrograde transport, endosome to Golgi//protein transport GO:0008565 protein transporter activity GO:0030904 retromer complex KOG1107 Membrane coat complex Retromer, subunit VPS35 Cluster-8309.34054 BF_2 67.00 4.94 855 642914652 XP_973930.2 663 7.3e-67 PREDICTED: protein DPCD [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5D8N2 414 2.2e-39 Protein DPCD OS=Xenopus laevis GN=dpcd PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34055 BF_2 159.00 5.21 1563 478263634 ENN81940.1 1413 1.4e-153 hypothetical protein YQE_01651, partial [Dendroctonus ponderosae]>gi|546672370|gb|ERL84269.1| hypothetical protein D910_01650 [Dendroctonus ponderosae]>gi|546682305|gb|ERL92258.1| hypothetical protein D910_09575 [Dendroctonus ponderosae] -- -- -- -- -- K14793 RRP9 ribosomal RNA-processing protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14793 O43818 871 4.2e-92 U3 small nucleolar RNA-interacting protein 2 OS=Homo sapiens GN=RRP9 PE=1 SV=1 PF00400//PF01621 WD domain, G-beta repeat//Cell fusion glycoprotein K -- -- GO:0005515 protein binding GO:0016020 membrane KOG0299 U3 snoRNP-associated protein (contains WD40 repeats) Cluster-8309.34056 BF_2 50.03 2.30 1197 91090912 XP_973979.1 222 1.4e-15 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47948 199 2.7e-14 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF13833//PF13405//PF00036//PF13499//PF13202 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.34057 BF_2 852.76 6.92 5439 642921494 XP_968130.3 3788 0.0e+00 PREDICTED: uncharacterized protein LOC656511 [Tribolium castaneum]>gi|270006226|gb|EFA02674.1| hypothetical protein TcasGA2_TC008395 [Tribolium castaneum] 642921493 XM_963037.3 224 7.46098e-111 PREDICTED: Tribolium castaneum uncharacterized LOC656511 (LOC656511), mRNA -- -- -- -- O43182 480 3.2e-46 Rho GTPase-activating protein 6 OS=Homo sapiens GN=ARHGAP6 PE=1 SV=3 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG2710 Rho GTPase-activating protein Cluster-8309.34058 BF_2 36.22 1.65 1203 353231251 CCD77669.1 928 1.9e-97 putative ubiquitin (ribosomal protein L40) [Schistosoma mansoni] 260830118 XM_002609963.1 308 3.25385e-158 Branchiostoma floridae hypothetical protein, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 923 3.0e-98 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF04452//PF14560//PF00240 RNA methyltransferase//Ubiquitin-like domain//Ubiquitin family GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.34059 BF_2 6.81 0.47 898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34061 BF_2 4.00 0.77 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34063 BF_2 332.47 2.90 5087 642927880 XP_008195434.1 2844 0.0e+00 PREDICTED: zinc finger protein 608-like isoform X1 [Tribolium castaneum] 642927883 XM_008197214.1 252 1.89856e-126 PREDICTED: Tribolium castaneum zinc finger protein 608-like (LOC662416), transcript variant X3, mRNA -- -- -- -- O15014 456 1.8e-43 Zinc finger protein 609 OS=Homo sapiens GN=ZNF609 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34065 BF_2 763.85 12.49 2845 642930858 XP_008196115.1 2856 0.0e+00 PREDICTED: oxysterol-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270012012|gb|EFA08460.1| hypothetical protein TcasGA2_TC006108 [Tribolium castaneum] 642930857 XM_008197893.1 257 1.75434e-129 PREDICTED: Tribolium castaneum oxysterol-binding protein 1 (LOC657071), transcript variant X1, mRNA -- -- -- -- P22059 1707 8.8e-189 Oxysterol-binding protein 1 OS=Homo sapiens GN=OSBP PE=1 SV=1 PF02371//PF05854 Transposase IS116/IS110/IS902 family//Non-histone chromosomal protein MC1 GO:0042262//GO:0006313 DNA protection//transposition, DNA-mediated GO:0003677//GO:0005543//GO:0004803 DNA binding//phospholipid binding//transposase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.34066 BF_2 20.55 1.85 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34067 BF_2 924.03 5.24 7661 189236457 XP_973878.2 4529 0.0e+00 PREDICTED: UHRF1-binding protein 1-like isoform X2 [Tribolium castaneum]>gi|270005939|gb|EFA02387.1| hypothetical protein TcasGA2_TC008067 [Tribolium castaneum] 507533084 XM_004650550.1 41 5.64088e-09 PREDICTED: Jaculus jaculus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA -- -- -- -- A0JNW5 989 4.3e-105 UHRF1-binding protein 1-like OS=Homo sapiens GN=UHRF1BP1L PE=1 SV=2 PF09208 Restriction endonuclease MspI GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG4109 Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 Cluster-8309.34069 BF_2 136.52 9.60 882 478255334 ENN75560.1 281 1.5e-22 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00917 MATH domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34070 BF_2 30.58 0.49 2877 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05625 PAXNEB protein -- -- -- -- GO:0033588 Elongator holoenzyme complex -- -- Cluster-8309.34073 BF_2 383.42 1.59 10381 270003689 EFA00137.1 2063 4.1e-228 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 270 3.83225e-136 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9V5L3 503 1.3e-48 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00439//PF00067//PF00631//PF02459 Bromodomain//Cytochrome P450//GGL domain//Adenoviral DNA terminal protein GO:0007165//GO:0006260//GO:0007186//GO:0055114 signal transduction//DNA replication//G-protein coupled receptor signaling pathway//oxidation-reduction process GO:0003677//GO:0016705//GO:0005515//GO:0004871//GO:0005506//GO:0020037 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//protein binding//signal transducer activity//iron ion binding//heme binding GO:0005834 heterotrimeric G-protein complex KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.34078 BF_2 4466.10 51.40 3922 642918534 XP_008191512.1 3754 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 401 0 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q6ZP82 504 3.8e-49 Coiled-coil domain-containing protein 141 OS=Homo sapiens GN=CCDC141 PE=1 SV=2 PF01544//PF00435 CorA-like Mg2+ transporter protein//Spectrin repeat GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873//GO:0005515 metal ion transmembrane transporter activity//protein binding GO:0016020 membrane -- -- Cluster-8309.34080 BF_2 49.86 0.88 2656 546681897 ERL91906.1 674 1.2e-67 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 347 4.1e-31 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34081 BF_2 1107.99 37.20 1533 546681897 ERL91906.1 906 8.7e-95 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 487 1.4e-47 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34082 BF_2 7.91 0.77 719 156320549 XP_001618200.1 218 2.5e-15 hypothetical protein NEMVEDRAFT_v1g155353 [Nematostella vectensis]>gi|156330400|ref|XP_001619109.1| hypothetical protein NEMVEDRAFT_v1g152336 [Nematostella vectensis]>gi|156197983|gb|EDO26100.1| predicted protein, partial [Nematostella vectensis]>gi|156201630|gb|EDO27009.1| predicted protein, partial [Nematostella vectensis] 496297311 KC573784.1 418 0 Carcinus maenas 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 180 2.6e-12 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34084 BF_2 443.97 2.51 7696 642919872 XP_008192104.1 4568 0.0e+00 PREDICTED: UHRF1-binding protein 1-like isoform X1 [Tribolium castaneum] 507533084 XM_004650550.1 41 5.66677e-09 PREDICTED: Jaculus jaculus UHRF1 binding protein 1-like (Uhrf1bp1l), mRNA -- -- -- -- A0JNW5 972 4.0e-103 UHRF1-binding protein 1-like OS=Homo sapiens GN=UHRF1BP1L PE=1 SV=2 PF09208 Restriction endonuclease MspI GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG4109 Histone H3 (Lys4) methyltransferase complex, subunit CPS25/DPY-30 Cluster-8309.34085 BF_2 6232.36 192.01 1645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34086 BF_2 365.75 4.49 3692 91084469 XP_970666.1 1690 2.6e-185 PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925528|ref|XP_008194588.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum]>gi|642925531|ref|XP_008194589.1| PREDICTED: zinc finger protein 350-like isoform X1 [Tribolium castaneum] 817200928 XM_012420774.1 171 1.46455e-81 PREDICTED: Orussus abietinus transcription factor Sp1-like (LOC105697447), transcript variant X5, mRNA -- -- -- -- P18722 282 2.0e-23 Gastrula zinc finger protein XlCGF46.1 (Fragment) OS=Xenopus laevis PE=3 SV=1 PF05191//PF00096//PF13465 Adenylate kinase, active site lid//Zinc finger, C2H2 type//Zinc-finger double domain GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.34089 BF_2 99.28 2.47 1966 91083483 XP_971803.1 1750 1.5e-192 PREDICTED: tubulin polyglutamylase TTLL4 [Tribolium castaneum]>gi|270010834|gb|EFA07282.1| hypothetical protein TcasGA2_TC014517 [Tribolium castaneum] -- -- -- -- -- K16610 TTLL15 tubulin monoglycylase TTLL15 http://www.genome.jp/dbget-bin/www_bget?ko:K16610 A4Q9E8 267 5.7e-22 Tubulin polyglutamylase TTLL6 OS=Mus musculus GN=Ttll6 PE=2 SV=1 PF03133//PF07478 Tubulin-tyrosine ligase family//D-ala D-ala ligase C-terminus GO:0006464//GO:0046436//GO:0009252 cellular protein modification process//D-alanine metabolic process//peptidoglycan biosynthetic process GO:0008716 D-alanine-D-alanine ligase activity -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.34090 BF_2 35.34 11.15 419 642922682 XP_008193278.1 379 3.1e-34 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X10 [Tribolium castaneum] -- -- -- -- -- K04550 LRP1, CD91 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) http://www.genome.jp/dbget-bin/www_bget?ko:K04550 Q9JI18 316 2.5e-28 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34091 BF_2 59.00 2.31 1354 478252125 ENN72556.1 715 1.1e-72 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 237 1.2e-18 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.34094 BF_2 400.55 3.31 5350 642920893 XP_973626.3 1474 4.2e-160 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09668 LARGE glycosyltransferase-like protein LARGE http://www.genome.jp/dbget-bin/www_bget?ko:K09668 Q66PG3 757 2.4e-78 Glycosyltransferase-like protein LARGE1 OS=Gallus gallus GN=LARGE PE=2 SV=1 PF00711//PF01545//PF01501//PF02844 Beta defensin//Cation efflux family//Glycosyl transferase family 8//Phosphoribosylglycinamide synthetase, N domain GO:0006812//GO:0055085//GO:0006144//GO:0006952//GO:0009113 cation transport//transmembrane transport//purine nucleobase metabolic process//defense response//purine nucleobase biosynthetic process GO:0008324//GO:0004637//GO:0016757 cation transmembrane transporter activity//phosphoribosylamine-glycine ligase activity//transferase activity, transferring glycosyl groups GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.34095 BF_2 691.99 65.37 730 91076494 XP_972946.1 560 5.5e-55 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 341 5.6e-31 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 PF01243 Pyridoxamine 5'-phosphate oxidase GO:0055114//GO:0008615 oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0016491//GO:0010181 pyridoxamine-phosphate oxidase activity//oxidoreductase activity//FMN binding -- -- KOG3374 Cellular repressor of transcription Cluster-8309.34096 BF_2 156.00 12.27 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34097 BF_2 817.41 7.43 4892 189238112 XP_001814047.1 481 5.3e-45 PREDICTED: bleomycin hydrolase [Tribolium castaneum]>gi|270008738|gb|EFA05186.1| hypothetical protein TcasGA2_TC015316 [Tribolium castaneum] 767931498 XM_005262871.3 83 1.61401e-32 PREDICTED: Homo sapiens KIAA0922 (KIAA0922), transcript variant X5, mRNA K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 Q8R016 366 4.7e-33 Bleomycin hydrolase OS=Mus musculus GN=Blmh PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG4128 Bleomycin hydrolases and aminopeptidases of cysteine protease family Cluster-8309.34098 BF_2 880.38 9.90 4007 642911078 XP_008200566.1 2834 0.0e+00 PREDICTED: RNA-binding protein 5 isoform X1 [Tribolium castaneum]>gi|270014669|gb|EFA11117.1| hypothetical protein TcasGA2_TC004717 [Tribolium castaneum] -- -- -- -- -- K13094 RBM5_10 RNA-binding protein 5/10 http://www.genome.jp/dbget-bin/www_bget?ko:K13094 A4IGK4 913 1.5e-96 RNA-binding protein 5 OS=Xenopus tropicalis GN=rbm5 PE=2 SV=1 PF01585//PF00641//PF00076 G-patch domain//Zn-finger in Ran binding protein and others//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166//GO:0008270 nucleic acid binding//nucleotide binding//zinc ion binding GO:0005622 intracellular KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.34099 BF_2 171.94 1.55 4929 642919308 XP_008191819.1 4470 0.0e+00 PREDICTED: signal-induced proliferation-associated 1-like protein 2 isoform X2 [Tribolium castaneum] 642919307 XM_008193597.1 101 1.60346e-42 PREDICTED: Tribolium castaneum signal-induced proliferation-associated 1-like protein 2 (LOC660473), transcript variant X2, mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q80TE4 1803 1.1e-199 Signal-induced proliferation-associated 1-like protein 2 OS=Mus musculus GN=Sipa1l2 PE=1 SV=3 PF06221//PF02145//PF00595 Putative zinc finger motif, C2HC5-type//Rap/ran-GAP//PDZ domain (Also known as DHR or GLGF) GO:0006355//GO:0051056 regulation of transcription, DNA-templated//regulation of small GTPase mediated signal transduction GO:0008270//GO:0005096//GO:0005515 zinc ion binding//GTPase activator activity//protein binding GO:0005634 nucleus KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.34100 BF_2 42.00 10.21 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34102 BF_2 715.26 6.50 4893 642938455 XP_008199810.1 4126 0.0e+00 PREDICTED: Niemann-Pick C1 protein isoform X1 [Tribolium castaneum] 657584210 XM_008298026.1 55 5.93077e-17 PREDICTED: Stegastes partitus Niemann-Pick disease, type C1 (npc1), transcript variant X2, mRNA K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 P56941 2256 3.3e-252 Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1 PF03176//PF02460//PF07677 MMPL family//Patched family//A-macroglobulin receptor GO:0007165 signal transduction GO:0008158 hedgehog receptor activity GO:0016020//GO:0005576 membrane//extracellular region KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.34106 BF_2 239.60 1.14 9053 642930846 XP_008196111.1 677 1.8e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34107 BF_2 673.75 10.64 2936 642929021 XP_008195658.1 2251 1.8e-250 PREDICTED: RNA-binding protein Nova-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14944 NOVA RNA-binding protein Nova http://www.genome.jp/dbget-bin/www_bget?ko:K14944 Q9UNW9 825 1.7e-86 RNA-binding protein Nova-2 OS=Homo sapiens GN=NOVA2 PE=1 SV=1 PF13184//PF13014//PF00013//PF07650 NusA-like KH domain//KH domain//KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2191 RNA-binding protein NOVA1/PASILLA and related KH domain proteins Cluster-8309.34108 BF_2 2329.92 74.35 1598 91089503 XP_970142.1 1262 4.8e-136 PREDICTED: chloride intracellular channel exc-4 [Tribolium castaneum]>gi|270011391|gb|EFA07839.1| hypothetical protein TcasGA2_TC005408 [Tribolium castaneum] 642933335 XM_965049.3 275 9.62747e-140 PREDICTED: Tribolium castaneum chloride intracellular channel exc-4 (LOC658685), mRNA -- -- -- -- Q8WQA4 439 5.3e-42 Chloride intracellular channel exc-4 OS=Caenorhabditis elegans GN=exc-4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1422 Intracellular Cl- channel CLIC, contains GST domain Cluster-8309.34110 BF_2 35.74 0.31 5090 91084129 XP_969781.1 3082 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 76 1.3078e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1310 1.7e-142 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06552//PF00005//PF03193//PF02456//PF00664//PF13304//PF01926 Plant specific mitochondrial import receptor subunit TOM20//ABC transporter//Protein of unknown function, DUF258//Adenovirus IVa2 protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0055085//GO:0019083//GO:0006810//GO:0006200//GO:0045040 transmembrane transport//viral transcription//transport//obsolete ATP catabolic process//protein import into mitochondrial outer membrane GO:0005524//GO:0003924//GO:0016887//GO:0005525//GO:0042626 ATP binding//GTPase activity//ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0005742 integral component of membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.34111 BF_2 83.33 0.37 9661 815897760 XP_012249603.1 195 1.5e-11 PREDICTED: gastrula zinc finger protein XlCGF26.1-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q96PQ6 148 1.8e-07 Zinc finger protein 317 OS=Homo sapiens GN=ZNF317 PE=1 SV=2 PF13465//PF02176//PF00096//PF02892//PF16622//PF01428 Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type//BED zinc finger//zinc-finger C2H2-type//AN1-like Zinc finger -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding -- -- -- -- Cluster-8309.34112 BF_2 59.92 1.75 1722 488510886 XP_004447524.1 544 9.3e-53 PREDICTED: zinc finger protein 227 [Dasypus novemcinctus]>gi|488510888|ref|XP_004447525.1| PREDICTED: zinc finger protein 227 [Dasypus novemcinctus]>gi|821099212|ref|XP_012380376.1| PREDICTED: zinc finger protein 227 [Dasypus novemcinctus] 880968524 XM_013125934.1 35 2.70354e-06 PREDICTED: Mesocricetus auratus zinc finger protein 431-like (LOC101825632), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86WZ6 527 3.6e-52 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF13465//PF00096//PF07776//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.34113 BF_2 352.04 15.80 1219 91082225 XP_976021.1 1003 3.9e-106 PREDICTED: four and a half LIM domains protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 O43900 375 1.1e-34 Prickle-like protein 3 OS=Homo sapiens GN=PRICKLE3 PE=1 SV=2 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.34114 BF_2 28.94 0.59 2339 91080595 XP_973935.1 1079 1.2e-114 PREDICTED: caseinolytic peptidase B protein homolog [Tribolium castaneum]>gi|270005512|gb|EFA01960.1| hypothetical protein TcasGA2_TC007578 [Tribolium castaneum] 612023545 XM_007491044.1 80 3.56401e-31 PREDICTED: Monodelphis domestica ClpB caseinolytic peptidase B homolog (E. coli) (CLPB), transcript variant X4, mRNA K03695 clpB ATP-dependent Clp protease ATP-binding subunit ClpB http://www.genome.jp/dbget-bin/www_bget?ko:K03695 Q9H078 847 3.8e-89 Caseinolytic peptidase B protein homolog OS=Homo sapiens GN=CLPB PE=1 SV=1 PF06414//PF03193//PF00023//PF00910//PF00158//PF13606//PF05496//PF08477//PF07728//PF00448//PF07724//PF06309//PF00004 Zeta toxin//Protein of unknown function, DUF258//Ankyrin repeat//RNA helicase//Sigma-54 interaction domain//Ankyrin repeat//Holliday junction DNA helicase ruvB N-terminus//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//SRP54-type protein, GTPase domain//AAA domain (Cdc48 subfamily)//Torsin//ATPase family associated with various cellular activities (AAA) GO:0007264//GO:0006310//GO:0006355//GO:0006281//GO:0006614 small GTPase mediated signal transduction//DNA recombination//regulation of transcription, DNA-templated//DNA repair//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0009378//GO:0017111//GO:0005525//GO:0005515//GO:0003723//GO:0016887//GO:0016301//GO:0003924//GO:0008134//GO:0005524 RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//GTP binding//protein binding//RNA binding//ATPase activity//kinase activity//GTPase activity//transcription factor binding//ATP binding GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases Cluster-8309.34115 BF_2 40.18 0.80 2387 91081621 XP_966892.1 1489 3.4e-162 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 862 7.1e-91 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.34116 BF_2 2.00 39.30 217 642928706 XP_008199748.1 324 3.8e-28 PREDICTED: microtubule-actin cross-linking factor 1 isoform X10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34118 BF_2 66.34 0.59 4963 642935120 XP_008197896.1 5377 0.0e+00 PREDICTED: vigilin [Tribolium castaneum]>gi|270013832|gb|EFA10280.1| hypothetical protein TcasGA2_TC012484 [Tribolium castaneum] 642935119 XM_008199674.1 502 0 PREDICTED: Tribolium castaneum vigilin (LOC658150), mRNA -- -- -- -- Q00341 3358 0.0e+00 Vigilin OS=Homo sapiens GN=HDLBP PE=1 SV=2 PF07650//PF13014//PF13184//PF00013//PF04055 KH domain//KH domain//NusA-like KH domain//KH domain//Radical SAM superfamily -- -- GO:0051536//GO:0003824//GO:0003723 iron-sulfur cluster binding//catalytic activity//RNA binding -- -- KOG2208 Vigilin Cluster-8309.34119 BF_2 4665.30 125.76 1839 478250805 ENN71297.1 680 1.7e-68 hypothetical protein YQE_12222, partial [Dendroctonus ponderosae] 768431929 XM_011558966.1 126 7.48917e-57 PREDICTED: Plutella xylostella troponin C (LOC105388115), mRNA -- -- -- -- P15159 411 1.1e-38 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13499//PF13405//PF13833//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.34122 BF_2 10.69 1.44 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34126 BF_2 906.02 17.52 2451 642919618 XP_008191942.1 2169 4.9e-241 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 423 0 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q4V920 1060 8.0e-114 Protein kinase C and casein kinase substrate in neurons protein 1 OS=Danio rerio GN=pacsin1b PE=1 SV=1 PF03938//PF01623//PF00018//PF14604//PF08397//PF03947 Outer membrane protein (OmpH-like)//Carlavirus putative nucleic acid binding protein//SH3 domain//Variant SH3 domain//IRSp53/MIM homology domain//Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006355//GO:0007009//GO:0006412 ribosome biogenesis//regulation of transcription, DNA-templated//plasma membrane organization//translation GO:0003735//GO:0051082//GO:0003676//GO:0005515 structural constituent of ribosome//unfolded protein binding//nucleic acid binding//protein binding GO:0005840 ribosome KOG2856 Adaptor protein PACSIN Cluster-8309.34127 BF_2 550.88 3.25 7388 642929723 XP_008195952.1 2535 5.4e-283 PREDICTED: spastin [Tribolium castaneum]>gi|270010589|gb|EFA07037.1| hypothetical protein TcasGA2_TC010011 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.44896e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q14738 2003 1.1e-222 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens GN=PPP2R5D PE=1 SV=1 PF00004//PF07724//PF01695//PF07728//PF05496//PF01603//PF06068 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//TIP49 C-terminus GO:0007165//GO:0006281//GO:0006310 signal transduction//DNA repair//DNA recombination GO:0008601//GO:0008568//GO:0005524//GO:0003678//GO:0016887//GO:0009378 protein phosphatase type 2A regulator activity//microtubule-severing ATPase activity//ATP binding//DNA helicase activity//ATPase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0000159 Holliday junction helicase complex//replication fork//protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.34129 BF_2 66.75 4.71 880 642910991 XP_008193498.1 509 5.4e-49 PREDICTED: FUN14 domain-containing protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17986 FUNDC1 FUN14 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17986 Q6DFJ3 245 9.2e-20 FUN14 domain-containing protein 1B OS=Xenopus laevis GN=fundc1-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4099 Predicted membrane protein Cluster-8309.34130 BF_2 408.52 11.54 1768 642938587 XP_008199853.1 144 2.3e-06 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 642938586 XM_008201631.1 130 4.2994e-59 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF01235 Sodium:alanine symporter family GO:0015846//GO:0006814//GO:0032328//GO:0015804 polyamine transport//sodium ion transport//alanine transport//neutral amino acid transport GO:0015655 alanine:sodium symporter activity GO:0016020 membrane -- -- Cluster-8309.34133 BF_2 1174.71 7.30 7023 642929789 XP_008195977.1 2705 9.9e-303 PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Tribolium castaneum] 118150627 NM_001077805.1 77 5.02461e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1707 2.2e-188 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF05093 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis GO:0016226 iron-sulfur cluster assembly GO:0051536 iron-sulfur cluster binding GO:0005737 cytoplasm KOG2210 Oxysterol-binding protein Cluster-8309.34134 BF_2 17.00 1.35 812 91084011 XP_975320.1 783 8.5e-81 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|270008251|gb|EFA04699.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H156 261 1.2e-21 SLIT and NTRK-like protein 2 OS=Homo sapiens GN=SLITRK2 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34135 BF_2 226.69 2.16 4669 91090558 XP_971487.1 1781 9.2e-196 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 751447204 XM_011179427.1 197 6.53492e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1017 1.5e-108 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF07959//PF00483//PF01128//PF01151 L-fucokinase//Nucleotidyl transferase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//GNS1/SUR4 family GO:0009058//GO:0008299//GO:0006694 biosynthetic process//isoprenoid biosynthetic process//steroid biosynthetic process GO:0016772//GO:0050518//GO:0016779 transferase activity, transferring phosphorus-containing groups//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.34137 BF_2 2028.37 19.62 4612 91091704 XP_972821.1 3200 0.0e+00 PREDICTED: phosphatidylinositol 4-kinase beta [Tribolium castaneum]>gi|270001265|gb|EEZ97712.1| four wheel drive [Tribolium castaneum] 830114741 XM_004689541.2 199 4.98965e-97 PREDICTED: Condylura cristata phosphatidylinositol 4-kinase, catalytic, beta (PI4KB), transcript variant X2, mRNA K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 B4UT09 1840 5.4e-204 Phosphatidylinositol 4-kinase beta OS=Otolemur garnettii GN=PI4KB PE=3 SV=1 PF08288//PF07415//PF00454 PIGA (GPI anchor biosynthesis)//Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphatidylinositol 3- and 4-kinase GO:0016310//GO:0006506//GO:0019042//GO:0046488 phosphorylation//GPI anchor biosynthetic process//viral latency//phosphatidylinositol metabolic process GO:0016301//GO:0016773 kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0033644 host cell membrane KOG0903 Phosphatidylinositol 4-kinase, involved in intracellular trafficking and secretion Cluster-8309.34138 BF_2 673.08 6.62 4542 642923932 XP_008193933.1 1449 2.8e-157 PREDICTED: choline-phosphate cytidylyltransferase A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K00968 PCYT1 choline-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00968 P49585 808 2.5e-84 Choline-phosphate cytidylyltransferase A OS=Homo sapiens GN=PCYT1A PE=1 SV=2 PF01733//PF12326//PF01467//PF00600 Nucleoside transporter//N-glycosylation protein//Cytidylyltransferase-like//Influenza non-structural protein (NS1) GO:0009058//GO:0034599//GO:0006810//GO:0015858 biosynthetic process//cellular response to oxidative stress//transport//nucleoside transport GO:0005337//GO:0003723//GO:0003824 nucleoside transmembrane transporter activity//RNA binding//catalytic activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.34140 BF_2 12.00 0.45 1406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34141 BF_2 1201.05 10.97 4866 642924963 XP_008194117.1 2699 3.4e-302 PREDICTED: coiled-coil domain-containing protein AGAP005037 isoform X9 [Tribolium castaneum] 795104299 XM_012026023.1 48 4.59165e-13 PREDICTED: Vollenhovia emeryi coiled-coil domain-containing protein CG32809 (LOC105569508), mRNA -- -- -- -- Q7PQ25 850 3.6e-89 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF01025//PF02970//PF07989 GrpE//Tubulin binding cofactor A//Centrosomin N-terminal motif 1 GO:0007021//GO:0006457 tubulin complex assembly//protein folding GO:0042803//GO:0051087//GO:0051082//GO:0000774//GO:0015631 protein homodimerization activity//chaperone binding//unfolded protein binding//adenyl-nucleotide exchange factor activity//tubulin binding GO:0045298//GO:0005815 tubulin complex//microtubule organizing center -- -- Cluster-8309.34143 BF_2 22.00 7.80 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01101 HMG14 and HMG17 -- -- GO:0031492 nucleosomal DNA binding GO:0000785//GO:0005634 chromatin//nucleus -- -- Cluster-8309.34145 BF_2 2086.50 35.77 2727 91091018 XP_975107.1 2378 3.2e-265 PREDICTED: F-box/LRR-repeat protein 2 isoform X1 [Tribolium castaneum]>gi|270013173|gb|EFA09621.1| hypothetical protein TcasGA2_TC011742 [Tribolium castaneum] 571506739 XM_397111.4 233 3.68979e-116 PREDICTED: Apis mellifera f-box/LRR-repeat protein 2-like (LOC413670), transcript variant X1, mRNA -- -- -- -- Q8BH16 206 9.4e-15 F-box/LRR-repeat protein 2 OS=Mus musculus GN=Fbxl2 PE=1 SV=1 PF12937//PF13639//PF15966//PF00646 F-box-like//Ring finger domain//F-box//F-box domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.34149 BF_2 4917.71 78.88 2895 761896177 AJP75146.1 2147 2.1e-238 alanine aminotransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q6NYL5 1513 2.8e-166 Alanine aminotransferase 2-like OS=Danio rerio GN=gpt2l PE=2 SV=2 PF01212//PF00155 Beta-eliminating lyase//Aminotransferase class I and II GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0258 Alanine aminotransferase Cluster-8309.3415 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34154 BF_2 104.93 1.27 3733 332372548 AEE61416.1 588 1.6e-57 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZJ3 200 6.4e-14 C3 and PZP-like alpha-2-macroglobulin domain-containing protein 8 OS=Homo sapiens GN=CPAMD8 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34155 BF_2 368.31 6.35 2714 642934848 XP_008197836.1 1564 7.8e-171 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 239 1.4e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34156 BF_2 6.47 0.43 918 642920332 XP_975626.2 404 8.5e-37 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078//PF04048 SWI5-dependent HO expression protein 3//Sec8 exocyst complex component specific domain GO:0051028//GO:0006904//GO:0048309//GO:0015031 mRNA transport//vesicle docking involved in exocytosis//endoplasmic reticulum inheritance//protein transport -- -- GO:0000145 exocyst KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.34158 BF_2 278.64 17.53 952 91078932 XP_967475.1 352 9.4e-31 PREDICTED: glutathione S-transferase [Tribolium castaneum]>gi|642916286|ref|XP_008190960.1| PREDICTED: glutathione S-transferase [Tribolium castaneum]>gi|270004172|gb|EFA00620.1| hypothetical protein TcasGA2_TC003496 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 O18598 347 1.5e-31 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3416 BF_2 4.00 0.51 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34160 BF_2 2354.62 60.07 1927 674304034 AIL23548.1 668 4.3e-67 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 607 2.1e-61 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.34161 BF_2 277.38 5.48 2406 674304034 AIL23548.1 668 5.4e-67 glutathione S-transferase sigma [Tenebrio molitor] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 602 1.0e-60 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1695 Glutathione S-transferase Cluster-8309.34164 BF_2 33.89 0.88 1906 642917782 XP_008191284.1 1769 9.2e-195 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [Tribolium castaneum] 170065886 XM_001868022.1 354 0 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 1661 1.3e-183 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.34166 BF_2 2181.97 138.75 945 91090704 XP_974824.1 366 2.2e-32 PREDICTED: putative acyl-CoA-binding protein [Tribolium castaneum]>gi|270013948|gb|EFA10396.1| hypothetical protein TcasGA2_TC012627 [Tribolium castaneum] -- -- -- -- -- K08762 DBI, ACBP diazepam-binding inhibitor (GABA receptor modulator, acyl-CoA-binding protein) http://www.genome.jp/dbget-bin/www_bget?ko:K08762 P31824 305 1.1e-26 Acyl-CoA-binding protein homolog OS=Manduca sexta PE=3 SV=1 PF00887//PF01613 Acyl CoA binding protein//Flavin reductase like domain -- -- GO:0000062//GO:0010181 fatty-acyl-CoA binding//FMN binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-8309.34168 BF_2 1008.96 13.86 3332 570341948 AHE77372.1 614 1.4e-60 small heat shock protein [Lissorhoptrus oryzophilus] 570341961 KC620429.1 60 6.68722e-20 Lissorhoptrus oryzophilus small heat shock protein (HSP27e) mRNA, partial cds K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 351 1.8e-31 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF09066//PF01873//PF00525 Beta2-adaptin appendage, C-terminal sub-domain//Domain found in IF2B/IF5//Alpha crystallin A chain, N terminal GO:0007423//GO:0016192//GO:0006446//GO:0006886//GO:0006413 sensory organ development//vesicle-mediated transport//regulation of translational initiation//intracellular protein transport//translational initiation GO:0003743//GO:0005212 translation initiation factor activity//structural constituent of eye lens GO:0030131//GO:0005840 clathrin adaptor complex//ribosome -- -- Cluster-8309.34169 BF_2 340.13 46.36 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3417 BF_2 81.00 2.45 1671 607353521 EZA48267.1 198 1.2e-12 hypothetical protein X777_14099 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34170 BF_2 493.00 9.31 2503 270013282 EFA09730.1 639 1.3e-63 hypothetical protein TcasGA2_TC011863 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0BM39 160 1.9e-09 Tetraspanin-9 OS=Xenopus tropicalis GN=tspan9 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.34172 BF_2 128.40 2.35 2572 546675568 ERL86737.1 1448 2.1e-157 hypothetical protein D910_04143 [Dendroctonus ponderosae] -- -- -- -- -- K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 605 4.8e-61 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF16622//PF02892//PF13912//PF13465//PF00096 BTB/POZ domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.34173 BF_2 120.63 1.12 4808 642923522 XP_008193544.1 3348 0.0e+00 PREDICTED: anoctamin-4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q32M45 1447 2.1e-158 Anoctamin-4 OS=Homo sapiens GN=ANO4 PE=2 SV=1 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- KOG2514 Uncharacterized conserved protein Cluster-8309.34174 BF_2 463.28 6.43 3302 478256841 ENN77016.1 1079 1.6e-114 hypothetical protein YQE_06510, partial [Dendroctonus ponderosae]>gi|546673799|gb|ERL85343.1| hypothetical protein D910_02763 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V785 768 7.8e-80 SH3 domain-binding protein 5 homolog OS=Drosophila melanogaster GN=pcs PE=1 SV=4 PF07851//PF01484 TMPIT-like protein//Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.34175 BF_2 40.08 0.84 2281 478252604 ENN73009.1 674 1.0e-67 hypothetical protein YQE_10344, partial [Dendroctonus ponderosae]>gi|546677975|gb|ERL88704.1| hypothetical protein D910_06086 [Dendroctonus ponderosae] -- -- -- -- -- K18264 ITM2B integral membrane protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K18264 Q3T0P7 179 1.1e-11 Integral membrane protein 2B OS=Bos taurus GN=ITM2B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4681 Uncharacterized conserved protein Cluster-8309.34178 BF_2 576.59 12.94 2151 91088951 XP_973830.1 922 1.7e-96 PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|642932526|ref|XP_008197151.1| PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011559|gb|EFA08007.1| hypothetical protein TcasGA2_TC005596 [Tribolium castaneum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 P16219 704 1.3e-72 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADS PE=1 SV=1 PF02770//PF00441//PF02771 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0006118//GO:0008152 oxidation-reduction process//obsolete electron transport//metabolic process GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.34179 BF_2 32.64 0.40 3677 91088951 XP_973830.1 871 2.4e-90 PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|642932526|ref|XP_008197151.1| PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011559|gb|EFA08007.1| hypothetical protein TcasGA2_TC005596 [Tribolium castaneum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 P16219 662 1.7e-67 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADS PE=1 SV=1 PF00441//PF02771//PF02770 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.34180 BF_2 18.34 0.50 1816 642937100 XP_008198691.1 689 1.5e-69 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 405 5.3e-38 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 PF00069//PF03121 Protein kinase domain//Herpesviridae UL52/UL70 DNA primase GO:0006468//GO:0006351//GO:0006260//GO:0006269 protein phosphorylation//transcription, DNA-templated//DNA replication//DNA replication, synthesis of RNA primer GO:0005524//GO:0003896//GO:0004672 ATP binding//DNA primase activity//protein kinase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.34181 BF_2 719.25 8.71 3743 270013391 EFA09839.1 785 2.3e-80 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 194893319 XM_001977817.1 90 1.58261e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- P08897 240 1.5e-18 Collagenase OS=Hypoderma lineatum PE=1 SV=3 PF00008//PF06373//PF00089 EGF-like domain//Cocaine and amphetamine regulated transcript protein (CART)//Trypsin GO:0009267//GO:0007186//GO:0000186//GO:0006508//GO:0001678//GO:0008343//GO:0032099 cellular response to starvation//G-protein coupled receptor signaling pathway//activation of MAPKK activity//proteolysis//cellular glucose homeostasis//adult feeding behavior//negative regulation of appetite GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding GO:0005615 extracellular space -- -- Cluster-8309.34186 BF_2 932.46 17.06 2573 642910945 XP_008193476.1 725 1.4e-73 PREDICTED: regulator of G-protein signaling 17 [Tribolium castaneum] 642910944 XM_008195254.1 78 5.07857e-30 PREDICTED: Tribolium castaneum regulator of G-protein signaling 17 (LOC661591), mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9PWA1 541 1.3e-53 Regulator of G-protein signaling 20 OS=Gallus gallus GN=RGS20 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3589 G protein signaling regulators Cluster-8309.34190 BF_2 856.72 6.44 5850 270002665 EEZ99112.1 1303 3.1e-140 hypothetical protein TcasGA2_TC005005 [Tribolium castaneum] 817188844 XM_012433587.1 77 4.18298e-29 PREDICTED: Orussus abietinus RING finger protein 44 (LOC105704395), partial mRNA K19041 RNF38_44 E3 ubiquitin-protein ligase RNF38/44 http://www.genome.jp/dbget-bin/www_bget?ko:K19041 Q08CG8 412 2.6e-38 RING finger protein 44 OS=Danio rerio GN=rnf44 PE=2 SV=1 PF17123//PF12906//PF12678//PF14634//PF00097//PF00287//PF12861//PF13639 RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Sodium / potassium ATPase beta chain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0006814//GO:0006813//GO:0016567 sodium ion transport//potassium ion transport//protein ubiquitination GO:0008270//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005890//GO:0005680 sodium:potassium-exchanging ATPase complex//anaphase-promoting complex -- -- Cluster-8309.34191 BF_2 381.48 9.22 2018 91094775 XP_968026.1 302 1.3e-24 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- K10146 CCNG2 cyclin G2 http://www.genome.jp/dbget-bin/www_bget?ko:K10146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34193 BF_2 22.65 0.37 2850 91080431 XP_968599.1 460 8.5e-43 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34195 BF_2 1122.42 23.99 2244 478263405 ENN81776.1 907 9.8e-95 hypothetical protein YQE_01836, partial [Dendroctonus ponderosae]>gi|546671271|gb|ERL83654.1| hypothetical protein D910_00815 [Dendroctonus ponderosae] 642926418 XM_965939.2 289 2.24487e-147 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2 G1 (LOC659653), mRNA K10575 UBE2G1, UBC7 ubiquitin-conjugating enzyme E2 G1 http://www.genome.jp/dbget-bin/www_bget?ko:K10575 P62253 784 7.4e-82 Ubiquitin-conjugating enzyme E2 G1 OS=Homo sapiens GN=UBE2G1 PE=1 SV=3 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0425 Ubiquitin-protein ligase Cluster-8309.34196 BF_2 287.94 1.86 6780 270007202 EFA03650.1 2336 5.9e-260 hypothetical protein TcasGA2_TC013744 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.9449e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 Q5SF07 1014 4.8e-108 Insulin-like growth factor 2 mRNA-binding protein 2 OS=Mus musculus GN=Igf2bp2 PE=1 SV=1 PF00076//PF07650//PF04061//PF00013//PF13014//PF13184 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//KH domain//ORMDL family//KH domain//KH domain//NusA-like KH domain -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.34199 BF_2 3734.00 81.66 2200 189234794 XP_001807213.1 1185 5.6e-127 PREDICTED: protein SMG5 [Tribolium castaneum] 642914408 XM_001807161.2 172 2.4121e-82 PREDICTED: Tribolium castaneum protein SMG5 (LOC100142092), mRNA K11125 SMG5, EST1B protein SMG5 http://www.genome.jp/dbget-bin/www_bget?ko:K11125 Q9UPR3 453 1.7e-43 Protein SMG5 OS=Homo sapiens GN=SMG5 PE=1 SV=3 PF13414//PF00515 TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG3300 NADH:ubiquinone oxidoreductase, B16.6 subunit/cell death-regulatory protein Cluster-8309.34200 BF_2 4420.94 16.18 11719 270011779 EFA08227.1 2250 9.5e-250 hypothetical protein TcasGA2_TC005854 [Tribolium castaneum] 642931619 XM_966443.2 176 7.77311e-84 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 Q92523 1265 6.5e-137 Carnitine O-palmitoyltransferase 1, muscle isoform OS=Homo sapiens GN=CPT1B PE=1 SV=2 PF00755//PF01532 Choline/Carnitine o-acyltransferase//Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571//GO:0016746 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2430 Glycosyl hydrolase, family 47 Cluster-8309.34203 BF_2 2.00 0.49 459 391347036 XP_003747771.1 518 2.6e-50 PREDICTED: myosin heavy chain, muscle-like [Metaseiulus occidentalis] -- -- -- -- -- K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 415 9.3e-40 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF02736//PF00063 Myosin N-terminal SH3-like domain//Myosin head (motor domain) -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.34205 BF_2 1420.19 117.91 791 642920914 XP_008192613.1 845 5.3e-88 PREDICTED: outer dense fiber protein 3-B isoform X2 [Tribolium castaneum]>gi|270006132|gb|EFA02580.1| hypothetical protein TcasGA2_TC008298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 266 3.0e-22 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 PF05953 Allatostatin GO:0007218 neuropeptide signaling pathway GO:0005184 neuropeptide hormone activity -- -- -- -- Cluster-8309.34206 BF_2 1743.00 137.62 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02935//PF00684 Cytochrome c oxidase subunit VIIc//DnaJ central domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0031072//GO:0051082 cytochrome-c oxidase activity//heat shock protein binding//unfolded protein binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.34207 BF_2 9.93 0.55 1049 91076434 XP_971068.1 378 1.0e-33 PREDICTED: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [Tribolium castaneum]>gi|270002571|gb|EEZ99018.1| hypothetical protein TcasGA2_TC004886 [Tribolium castaneum] -- -- -- -- -- K12846 SNRNP27 U4/U6.U5 tri-snRNP-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12846 Q8WVK2 239 5.4e-19 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens GN=SNRNP27 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3263 Nucleic acid binding protein Cluster-8309.34208 BF_2 508.07 31.54 961 91076434 XP_971068.1 378 9.2e-34 PREDICTED: U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein [Tribolium castaneum]>gi|270002571|gb|EEZ99018.1| hypothetical protein TcasGA2_TC004886 [Tribolium castaneum] -- -- -- -- -- K12846 SNRNP27 U4/U6.U5 tri-snRNP-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12846 Q8WVK2 239 4.9e-19 U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein OS=Homo sapiens GN=SNRNP27 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3263 Nucleic acid binding protein Cluster-8309.34210 BF_2 24.55 0.99 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34212 BF_2 594.84 37.20 956 332376981 AEE63630.1 250 6.4e-19 unknown [Dendroctonus ponderosae]>gi|478249889|gb|ENN70396.1| hypothetical protein YQE_12902, partial [Dendroctonus ponderosae]>gi|546683395|gb|ERL93214.1| hypothetical protein D910_10510 [Dendroctonus ponderosae] -- -- -- -- -- K17784 MINOS1, MOS1 mitochondrial inner membrane organizing system protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17784 Q5TGZ0 152 6.0e-09 MICOS complex subunit MIC10 OS=Homo sapiens GN=MINOS1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4604 Uncharacterized conserved protein Cluster-8309.34214 BF_2 68.40 1.31 2466 642937569 XP_008199101.1 2344 2.5e-261 PREDICTED: amidophosphoribosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1926 3.1e-214 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF00156 Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process -- -- -- -- KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.34215 BF_2 742.95 9.96 3409 668453610 KFB42261.1 1592 5.5e-174 AGAP009649-PA-like protein [Anopheles sinensis] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9NRA2 826 1.5e-86 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690//PF06963//PF00083 Major Facilitator Superfamily//Ferroportin1 (FPN1)//Sugar (and other) transporter GO:0006826//GO:0034755//GO:0055085 iron ion transport//iron ion transmembrane transport//transmembrane transport GO:0022857//GO:0005381 transmembrane transporter activity//iron ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.34216 BF_2 432.24 12.53 1730 642928374 XP_008192717.1 944 3.9e-99 PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X1 [Tribolium castaneum] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 852 7.4e-90 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF02882//PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.34217 BF_2 1440.81 7.72 8092 642925750 XP_008201602.1 1207 5.8e-129 PREDICTED: micronuclear linker histone polyprotein-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00999 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00999 O14735 640 1.3e-64 CDP-diacylglycerol--inositol 3-phosphatidyltransferase OS=Homo sapiens GN=CDIPT PE=1 SV=1 PF03967//PF01066 Photosynthetic reaction centre, H-chain N-terminal region//CDP-alcohol phosphatidyltransferase GO:0019684//GO:0008654//GO:0006118 photosynthesis, light reaction//phospholipid biosynthetic process//obsolete electron transport GO:0045156//GO:0016780 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//phosphotransferase activity, for other substituted phosphate groups GO:0030077//GO:0016020 plasma membrane light-harvesting complex//membrane KOG3240 Phosphatidylinositol synthase Cluster-8309.34218 BF_2 33.45 0.59 2668 332374254 AEE62268.1 1201 9.4e-129 unknown [Dendroctonus ponderosae]>gi|546686166|gb|ERL95552.1| hypothetical protein D910_12813 [Dendroctonus ponderosae] -- -- -- -- -- K09507 DNAJB1 DnaJ homolog subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09507 Q24133 767 8.2e-80 DnaJ protein homolog 1 OS=Drosophila melanogaster GN=DnaJ-1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.34223 BF_2 42.24 0.47 4077 390198528 AFL70631.1 1221 6.9e-131 putative hypoxia-inducible factor 1 alpha [Callosobruchus maculatus] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.34224 BF_2 73.00 4.64 946 189237508 XP_972374.2 584 1.2e-57 PREDICTED: protein D2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 471 6.1e-46 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.34225 BF_2 200.00 2.38 3805 642937943 XP_969804.2 1363 2.2e-147 PREDICTED: YTH domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96MU7 584 1.9e-58 YTH domain-containing protein 1 OS=Homo sapiens GN=YTHDC1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1902 Putative signal transduction protein involved in RNA splicing Cluster-8309.34226 BF_2 7.00 0.82 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34227 BF_2 7666.64 679.70 759 332375004 AEE62643.1 598 2.2e-59 unknown [Dendroctonus ponderosae]>gi|478258425|gb|ENN78519.1| hypothetical protein YQE_05012, partial [Dendroctonus ponderosae]>gi|546676434|gb|ERL87445.1| hypothetical protein D910_04837 [Dendroctonus ponderosae] -- -- -- -- -- K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 268 1.7e-22 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.34228 BF_2 0.92 14.00 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34229 BF_2 399.61 2.26 7670 642938169 XP_008190998.1 1045 3.3e-110 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NQ0 440 2.0e-41 G-protein coupled receptor Mth2 OS=Drosophila simulans GN=mth2 PE=3 SV=1 PF00002//PF06652//PF00001//PF04644 7 transmembrane receptor (Secretin family)//Methuselah N-terminus//7 transmembrane receptor (rhodopsin family)//Motilin/ghrelin GO:0007165//GO:0007186//GO:0006950 signal transduction//G-protein coupled receptor signaling pathway//response to stress GO:0004930//GO:0005179 G-protein coupled receptor activity//hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.3423 BF_2 121.00 4.47 1420 91080329 XP_974555.1 1129 1.1e-120 PREDICTED: mitochondrial ornithine transporter 1 [Tribolium castaneum]>gi|270005604|gb|EFA02052.1| hypothetical protein TcasGA2_TC007680 [Tribolium castaneum] -- -- -- -- -- K15101 SLC25A2_15, ORNT solute carrier family 25 (mitochondrial ornithine transporter) member 2/15 http://www.genome.jp/dbget-bin/www_bget?ko:K15101 Q9Y619 683 2.4e-70 Mitochondrial ornithine transporter 1 OS=Homo sapiens GN=SLC25A15 PE=1 SV=1 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG0758 Mitochondrial carnitine-acylcarnitine carrier protein Cluster-8309.34230 BF_2 417.54 3.02 6065 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF04183//PF02207//PF02617//PF01599 IucA / IucC family//Putative zinc finger in N-recognin (UBR box)//ATP-dependent Clp protease adaptor protein ClpS//Ribosomal protein S27a GO:0016567//GO:0006412//GO:0019290//GO:0006826//GO:0030163//GO:0042254 protein ubiquitination//translation//siderophore biosynthetic process//iron ion transport//protein catabolic process//ribosome biogenesis GO:0004842//GO:0015343//GO:0008270//GO:0003735 ubiquitin-protein transferase activity//siderophore transmembrane transporter activity//zinc ion binding//structural constituent of ribosome GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.34232 BF_2 272.36 1.85 6460 642938175 XP_008191019.1 799 9.4e-82 PREDICTED: G-protein coupled receptor Mth2-like isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 333 4.2e-29 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF04644//PF00002 Motilin/ghrelin//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0004930//GO:0005179 G-protein coupled receptor activity//hormone activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.34234 BF_2 50.00 9.42 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34235 BF_2 722.43 4.05 7751 642938169 XP_008190998.1 1053 4.0e-111 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 470 6.6e-45 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF04644//PF00001//PF06652//PF00002 Motilin/ghrelin//7 transmembrane receptor (rhodopsin family)//Methuselah N-terminus//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186//GO:0006950 signal transduction//G-protein coupled receptor signaling pathway//response to stress GO:0005179//GO:0004930 hormone activity//G-protein coupled receptor activity GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.34236 BF_2 20.00 0.94 1178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34237 BF_2 31.95 0.34 4249 478253163 ENN73534.1 187 5.7e-11 hypothetical protein YQE_09785, partial [Dendroctonus ponderosae] -- -- -- -- -- K09370 ISL1 insulin gene enhancer protein ISL-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09370 P61371 178 2.6e-11 Insulin gene enhancer protein ISL-1 OS=Homo sapiens GN=ISL1 PE=1 SV=1 PF02701//PF13465//PF00412//PF02892//PF05495//PF00096//PF00046//PF05920 Dof domain, zinc finger//Zinc-finger double domain//LIM domain//BED zinc finger//CHY zinc finger//Zinc finger, C2H2 type//Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding -- -- KOG4577 Transcription factor LIM3, contains LIM and HOX domains Cluster-8309.34240 BF_2 213.86 2.25 4270 642918984 XP_008191685.1 4678 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X6 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.32984e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF05109//PF00122 Herpes virus major outer envelope glycoprotein (BLLF1)//E1-E2 ATPase GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.34242 BF_2 330.21 24.54 850 642913424 XP_008201005.1 193 2.3e-12 PREDICTED: calcium-binding mitochondrial carrier protein Aralar1 [Tribolium castaneum] -- -- -- -- -- K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q21153 156 1.8e-09 Probable calcium-binding mitochondrial carrier K02F3.2 OS=Caenorhabditis elegans GN=K02F3.2 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.34243 BF_2 2325.21 119.23 1103 189237141 XP_973425.2 674 5.0e-68 PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like isoform X2 [Tribolium castaneum] 665410487 NM_176340.3 35 1.71369e-06 Drosophila melanogaster neural conserved at 73EF (Nc73EF), transcript variant F, mRNA K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 323 1.0e-28 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.34244 BF_2 15.00 1.56 689 478251302 ENN71770.1 174 3.0e-10 hypothetical protein YQE_11505, partial [Dendroctonus ponderosae]>gi|546678660|gb|ERL89232.1| hypothetical protein D910_06606 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34245 BF_2 149.32 1.51 4430 478252433 ENN72856.1 1892 1.2e-208 hypothetical protein YQE_10505, partial [Dendroctonus ponderosae]>gi|478264876|gb|ENN82355.1| hypothetical protein YQE_01270, partial [Dendroctonus ponderosae] 157136696 XM_001656830.1 41 3.25207e-09 Aedes aegypti AAEL013617-RA partial mRNA -- -- -- -- P52757 923 1.1e-97 Beta-chimaerin OS=Homo sapiens GN=CHN2 PE=1 SV=2 PF00130//PF00620//PF04434//PF01363 Phorbol esters/diacylglycerol binding domain (C1 domain)//RhoGAP domain//SWIM zinc finger//FYVE zinc finger GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.34246 BF_2 3722.43 15.66 10231 642911435 XP_008199422.1 2703 2.5e-302 PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911437|ref|XP_008199423.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum]>gi|642911439|ref|XP_008199424.1| PREDICTED: furin-like protease 1, isoform 1-CRR isoform X1 [Tribolium castaneum] -- -- -- -- -- K01349 FURIN, PCSK3 furin http://www.genome.jp/dbget-bin/www_bget?ko:K01349 P30430 1976 2.0e-219 Furin-like protease 1, isoform 1-CRR OS=Drosophila melanogaster GN=Fur1 PE=2 SV=2 PF08496//PF00082//PF09458//PF01483 Peptidase family S49 N-terminal//Subtilase family//H-type lectin domain//Proprotein convertase P-domain GO:0007155//GO:0006508 cell adhesion//proteolysis GO:0004252//GO:0030246 serine-type endopeptidase activity//carbohydrate binding GO:0005886 plasma membrane KOG3525 Subtilisin-like proprotein convertase Cluster-8309.34247 BF_2 48.79 0.94 2459 478256664 ENN76846.1 1026 1.7e-108 hypothetical protein YQE_06687, partial [Dendroctonus ponderosae]>gi|546685138|gb|ERL94665.1| hypothetical protein D910_11940 [Dendroctonus ponderosae] 815782412 XM_012359088.1 110 7.89006e-48 PREDICTED: Linepithema humile adenylate kinase (LOC105667343), mRNA K00939 adk, AK adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00939 Q9U915 954 1.6e-101 Adenylate kinase OS=Drosophila melanogaster GN=Adk2 PE=1 SV=1 PF02224//PF02892//PF05191 Cytidylate kinase//BED zinc finger//Adenylate kinase, active site lid GO:0006206//GO:0006139//GO:0046034//GO:0006144 pyrimidine nucleobase metabolic process//nucleobase-containing compound metabolic process//ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0004127//GO:0003677//GO:0005524 adenylate kinase activity//cytidylate kinase activity//DNA binding//ATP binding -- -- KOG3078 Adenylate kinase Cluster-8309.34248 BF_2 917.90 18.34 2381 478256664 ENN76846.1 1026 1.7e-108 hypothetical protein YQE_06687, partial [Dendroctonus ponderosae]>gi|546685138|gb|ERL94665.1| hypothetical protein D910_11940 [Dendroctonus ponderosae] 815782412 XM_012359088.1 110 7.63618e-48 PREDICTED: Linepithema humile adenylate kinase (LOC105667343), mRNA K00939 adk, AK adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00939 Q9U915 954 1.5e-101 Adenylate kinase OS=Drosophila melanogaster GN=Adk2 PE=1 SV=1 PF05191//PF02892//PF02224 Adenylate kinase, active site lid//BED zinc finger//Cytidylate kinase GO:0006139//GO:0046034//GO:0006144//GO:0006206 nucleobase-containing compound metabolic process//ATP metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0005524//GO:0004017//GO:0004127 DNA binding//ATP binding//adenylate kinase activity//cytidylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.34249 BF_2 320.00 16.13 1117 91081671 XP_969903.1 758 9.2e-78 PREDICTED: malignant T-cell-amplified sequence 1-A [Tribolium castaneum]>gi|270006240|gb|EFA02688.1| hypothetical protein TcasGA2_TC008409 [Tribolium castaneum] -- -- -- -- -- K07575 K07575 PUA domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K07575 Q9W445 624 1.3e-63 Malignant T-cell-amplified sequence 1 homolog OS=Drosophila melanogaster GN=MCTS1 PE=1 SV=1 PF01472 PUA domain -- -- GO:0003723 RNA binding -- -- KOG2523 Predicted RNA-binding protein with PUA domain Cluster-8309.3425 BF_2 61.89 2.77 1222 642923225 XP_008193663.1 759 7.7e-78 PREDICTED: ribonuclease P protein subunit p30 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P78346 265 6.1e-22 Ribonuclease P protein subunit p30 OS=Homo sapiens GN=RPP30 PE=1 SV=1 PF01876 RNase P subunit p30 GO:0051252//GO:0008033 regulation of RNA metabolic process//tRNA processing GO:0004540 ribonuclease activity -- -- KOG2363 Protein subunit of nuclear ribonuclease P (RNase P) Cluster-8309.34250 BF_2 120.59 3.12 1902 642915291 XP_008190557.1 1102 2.0e-117 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 768 4.5e-80 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF10410//PF02985//PF00311//PF01602 DnaB-helicase binding domain of primase//HEAT repeat//Phosphoenolpyruvate carboxylase//Adaptin N terminal region GO:0015977//GO:0019643//GO:0006886//GO:0016192//GO:0006094//GO:0006099 carbon fixation//reductive tricarboxylic acid cycle//intracellular protein transport//vesicle-mediated transport//gluconeogenesis//tricarboxylic acid cycle GO:0008964//GO:0005515//GO:0016779 phosphoenolpyruvate carboxylase activity//protein binding//nucleotidyltransferase activity GO:0030117 membrane coat -- -- Cluster-8309.34252 BF_2 834.74 11.02 3457 642935594 XP_008198075.1 2999 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I isoform X13 [Tribolium castaneum] 642935593 XM_008199853.1 1016 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X15, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 Q9W4T4 2498 2.0e-280 cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I OS=Drosophila melanogaster GN=dnc PE=1 SV=2 PF07469//PF00233 Domain of unknown function (DUF1518)//3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.34253 BF_2 685.75 6.44 4742 478255214 ENN75443.1 905 3.5e-94 hypothetical protein YQE_07994, partial [Dendroctonus ponderosae]>gi|546675119|gb|ERL86366.1| hypothetical protein D910_03774 [Dendroctonus ponderosae] 805772222 XM_012281473.1 98 7.17508e-41 PREDICTED: Megachile rotundata probable protein phosphatase CG10417 (LOC100882395), mRNA K17499 PPM1G, PP2CG protein phosphatase 1G http://www.genome.jp/dbget-bin/www_bget?ko:K17499 Q7K4Q5 760 9.5e-79 Probable protein phosphatase CG10417 OS=Drosophila melanogaster GN=CG10417 PE=1 SV=1 PF00481//PF01251//PF07228 Protein phosphatase 2C//Ribosomal protein S7e//Stage II sporulation protein E (SpoIIE) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0698 Serine/threonine protein phosphatase Cluster-8309.34254 BF_2 403.55 21.56 1070 642924642 XP_008194376.1 626 1.8e-62 PREDICTED: tensin isoform X2 [Tribolium castaneum] -- -- -- -- -- K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 -- -- -- -- PF00130//PF01688 Phorbol esters/diacylglycerol binding domain (C1 domain)//Alphaherpesvirus glycoprotein I GO:0035556 intracellular signal transduction -- -- GO:0043657 host cell -- -- Cluster-8309.34255 BF_2 71.14 1.61 2141 270013857 EFA10305.1 172 1.6e-09 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34256 BF_2 52.93 1.28 2017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34257 BF_2 2515.00 212.61 782 91077486 XP_968733.1 780 1.8e-80 PREDICTED: ATP synthase subunit O, mitochondrial [Tribolium castaneum]>gi|270002753|gb|EEZ99200.1| oligomycin sensitivity-conferring protein [Tribolium castaneum] -- -- -- -- -- K02137 ATPeF0O, ATP5O, ATP5 F-type H+-transporting ATPase subunit O http://www.genome.jp/dbget-bin/www_bget?ko:K02137 Q24439 605 1.5e-61 ATP synthase subunit O, mitochondrial OS=Drosophila melanogaster GN=Oscp PE=2 SV=2 PF00213 ATP synthase delta (OSCP) subunit GO:0015986 ATP synthesis coupled proton transport GO:0046933 proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex KOG1662 Mitochondrial F1F0-ATP synthase, subunit OSCP/ATP5 Cluster-8309.34258 BF_2 3.75 0.54 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34262 BF_2 761.37 5.89 5693 642923755 XP_008193870.1 936 1.1e-97 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 1.2e-56 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0051302//GO:0051726//GO:0045859 regulation of cell division//regulation of cell cycle//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.34266 BF_2 1896.00 75.19 1342 91088601 XP_973643.1 1864 6.3e-206 PREDICTED: 26S proteasome non-ATPase regulatory subunit 6 [Tribolium castaneum]>gi|270012256|gb|EFA08704.1| hypothetical protein TcasGA2_TC006375 [Tribolium castaneum] 632955242 XM_007895182.1 74 4.37636e-28 PREDICTED: Callorhinchus milii proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 (psmd6), mRNA K03037 PSMD6, RPN7 26S proteasome regulatory subunit N7 http://www.genome.jp/dbget-bin/www_bget?ko:K03037 Q9V3G7 1486 1.8e-163 26S proteasome non-ATPase regulatory subunit 6 OS=Drosophila melanogaster GN=Rpn7 PE=2 SV=1 PF13181//PF01399//PF13176 Tetratricopeptide repeat//PCI domain//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0687 26S proteasome regulatory complex, subunit RPN7/PSMD6 Cluster-8309.34268 BF_2 3183.29 165.05 1094 91086693 XP_969563.1 542 1.0e-52 PREDICTED: 12 kDa FK506-binding protein [Tribolium castaneum]>gi|270010405|gb|EFA06853.1| hypothetical protein TcasGA2_TC009796 [Tribolium castaneum] -- -- -- -- -- K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P18203 475 2.4e-46 Peptidyl-prolyl cis-trans isomerase FKBP1A OS=Bos taurus GN=FKBP1A PE=1 SV=2 PF01581//PF00254 FMRFamide related peptide family//FKBP-type peptidyl-prolyl cis-trans isomerase GO:0006457//GO:0007218//GO:0000413 protein folding//neuropeptide signaling pathway//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.34270 BF_2 150.02 11.03 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF08107 Arthropod defensin//Pleurocidin family GO:0042742//GO:0006952 defense response to bacterium//defense response -- -- -- -- -- -- Cluster-8309.34275 BF_2 405.84 2.29 7702 189241221 XP_001812199.1 1084 1.0e-114 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 746 6.5e-77 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF01166//PF07544//PF04952//PF04977//PF05531//PF16326//PF00246//PF06008 TSC-22/dip/bun family//RNA polymerase II transcription mediator complex subunit 9//Succinylglutamate desuccinylase / Aspartoacylase family//Septum formation initiator//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Zinc carboxypeptidase//Laminin Domain I GO:0008152//GO:0030155//GO:0006508//GO:0030334//GO:0007165//GO:0007049//GO:0045995//GO:0006357//GO:0006355 metabolic process//regulation of cell adhesion//proteolysis//regulation of cell migration//signal transduction//cell cycle//regulation of embryonic development//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0016788//GO:0003677//GO:0001104//GO:0004181//GO:0003700//GO:0008270//GO:0005102 hydrolase activity, acting on ester bonds//DNA binding//RNA polymerase II transcription cofactor activity//metallocarboxypeptidase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//receptor binding GO:0005667//GO:0016592//GO:0019028 transcription factor complex//mediator complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.34276 BF_2 11.83 0.33 1801 546684637 ERL94254.1 1892 4.8e-209 hypothetical protein D910_11535 [Dendroctonus ponderosae] 676425561 XM_009046107.1 164 5.5094e-78 Lottia gigantea hypothetical protein partial mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 Q8HXY7 1561 4.7e-172 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Macaca fascicularis GN=ACADVL PE=2 SV=1 PF02770//PF00441//PF02771 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0008152//GO:0006118 oxidation-reduction process//metabolic process//obsolete electron transport GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.34278 BF_2 409.26 10.30 1949 270011937 EFA08385.1 1820 1.2e-200 hypothetical protein TcasGA2_TC006029 [Tribolium castaneum] -- -- -- -- -- K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 1338 3.7e-146 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF11744//PF01207 Aluminium activated malate transporter//Dihydrouridine synthase (Dus) GO:0055114//GO:0015743//GO:0008033 oxidation-reduction process//malate transport//tRNA processing GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.34279 BF_2 1803.42 17.42 4617 642910583 XP_008200013.1 3042 0.0e+00 PREDICTED: cap-n-collar isoform X4 [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 6.6e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF03131//PF03126//PF00170//PF07716 bZIP Maf transcription factor//Plus-3 domain//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3863 bZIP transcription factor NRF1 Cluster-8309.34281 BF_2 5433.62 83.30 3016 332376933 AEE63606.1 1622 1.6e-177 unknown [Dendroctonus ponderosae] 827538802 XM_012696885.1 74 9.97511e-28 PREDICTED: Bombyx mori phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (LOC101743489), transcript variant X3, mRNA K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q01604 1393 2.4e-152 Phosphoglycerate kinase OS=Drosophila melanogaster GN=Pgk PE=2 SV=2 PF00162//PF00069 Phosphoglycerate kinase//Protein kinase domain GO:0015976//GO:0006094//GO:0006096//GO:0006468//GO:0016310 carbon utilization//gluconeogenesis//glycolytic process//protein phosphorylation//phosphorylation GO:0004672//GO:0005524//GO:0004618 protein kinase activity//ATP binding//phosphoglycerate kinase activity -- -- KOG1367 3-phosphoglycerate kinase Cluster-8309.34282 BF_2 864.41 8.78 4407 91082905 XP_972330.1 2058 6.6e-228 PREDICTED: eukaryotic translation initiation factor 2A [Tribolium castaneum]>gi|270007067|gb|EFA03515.1| hypothetical protein TcasGA2_TC013517 [Tribolium castaneum] -- -- -- -- -- K15026 EIF2A translation initiation factor 2A http://www.genome.jp/dbget-bin/www_bget?ko:K15026 Q7ZY11 1191 9.3e-129 Eukaryotic translation initiation factor 2A OS=Xenopus laevis GN=eif2a PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.34283 BF_2 54.68 1.67 1653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34286 BF_2 18.00 1.16 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34288 BF_2 229.14 5.39 2064 546682276 ERL92237.1 1300 2.4e-140 hypothetical protein D910_09554 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5BKL1 595 5.6e-60 UPF0415 protein C7orf25 homolog OS=Xenopus tropicalis GN=TGas015c11.1 PE=2 SV=1 PF04987 Phosphatidylinositolglycan class N (PIG-N) GO:0006506 GPI anchor biosynthetic process GO:0016740 transferase activity GO:0005789 endoplasmic reticulum membrane KOG4529 Uncharacterized conserved protein Cluster-8309.34289 BF_2 37.73 0.62 2819 769856445 XP_011639821.1 296 8.7e-24 PREDICTED: LOW QUALITY PROTEIN: GTP-binding protein SAR1b [Pogonomyrmex barbatus] 817214492 XM_012428063.1 59 2.03081e-19 PREDICTED: Orussus abietinus GTP-binding protein SAR1b (LOC105701368), transcript variant X6, mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q23445 235 4.2e-18 GTP-binding protein SAR1 OS=Caenorhabditis elegans GN=ZK180.4 PE=3 SV=1 PF01926//PF08477//PF00025//PF10662//PF05493 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//ATP synthase subunit H GO:0006576//GO:0015991//GO:0007264//GO:0015992 cellular biogenic amine metabolic process//ATP hydrolysis coupled proton transport//small GTPase mediated signal transduction//proton transport GO:0005524//GO:0005525//GO:0015078 ATP binding//GTP binding//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.34290 BF_2 3337.00 29.48 5023 642915428 XP_008190611.1 5803 0.0e+00 PREDICTED: clustered mitochondria protein homolog [Tribolium castaneum]>gi|270004006|gb|EFA00454.1| hypothetical protein TcasGA2_TC003310 [Tribolium castaneum] 571519225 XM_006563927.1 413 0 PREDICTED: Apis mellifera protein KIAA0664 homolog (LOC552519), transcript variant X1, mRNA K03255 TIF31, CLU1 protein TIF31 http://www.genome.jp/dbget-bin/www_bget?ko:K03255 Q17N71 4738 0.0e+00 Clustered mitochondria protein homolog OS=Aedes aegypti GN=AAEL000794 PE=3 SV=1 PF13181//PF13374//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG1839 Uncharacterized protein CLU1/cluA/TIF31 involved in mitochondrial morphology/distribution, also found associated with eIF-3 Cluster-8309.34291 BF_2 142.19 4.30 1669 332372728 AEE61506.1 1350 3.1e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q6GLK6 706 6.1e-73 Acyl-CoA synthetase family member 3, mitochondrial OS=Xenopus laevis GN=acsf3 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.34292 BF_2 535.00 38.66 866 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34293 BF_2 266.42 4.14 2981 546677419 ERL88256.1 1003 9.6e-106 hypothetical protein D910_05644 [Dendroctonus ponderosae] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q3URE1 634 2.4e-64 Acyl-CoA synthetase family member 3, mitochondrial OS=Mus musculus GN=Acsf3 PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.34294 BF_2 194.72 3.40 2682 332374778 AEE62530.1 3000 0.0e+00 unknown [Dendroctonus ponderosae]>gi|478257113|gb|ENN77276.1| hypothetical protein YQE_06103, partial [Dendroctonus ponderosae]>gi|546683351|gb|ERL93173.1| hypothetical protein D910_10470 [Dendroctonus ponderosae] 264667372 GU120422.1 126 1.09812e-56 Chrysomela tremulae ribosomal protein S18 (RpS18) mRNA, complete cds -- -- -- -- Q5TJF0 1789 2.6e-198 Vacuolar protein sorting-associated protein 52 homolog OS=Canis familiaris GN=VPS52 PE=3 SV=1 PF08716//PF00416//PF05192 nsp7 replicase//Ribosomal protein S13/S18//MutS domain III GO:0006412//GO:0006298//GO:0042254//GO:0006508 translation//mismatch repair//ribosome biogenesis//proteolysis GO:0008242//GO:0016740//GO:0003723//GO:0005524//GO:0004197//GO:0030983//GO:0003735 omega peptidase activity//transferase activity//RNA binding//ATP binding//cysteine-type endopeptidase activity//mismatched DNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1961 Vacuolar sorting protein VPS52/suppressor of actin Sac2 Cluster-8309.34295 BF_2 920.00 44.30 1156 642931531 XP_008196624.1 391 3.4e-35 PREDICTED: 28 kDa heat- and acid-stable phosphoprotein-like [Tribolium castaneum]>gi|270011801|gb|EFA08249.1| hypothetical protein TcasGA2_TC005877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UHX2 193 1.3e-13 28 kDa heat- and acid-stable phosphoprotein OS=Mus musculus GN=Pdap1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3375 Phosphoprotein/predicted coiled-coil protein Cluster-8309.34296 BF_2 5.00 6.58 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34297 BF_2 168.72 3.42 2348 478258940 ENN78915.1 859 3.8e-89 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q8CHP8 475 5.2e-46 Phosphoglycolate phosphatase OS=Mus musculus GN=Pgp PE=1 SV=1 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.34299 BF_2 11.87 0.33 1797 170321833 BAG14261.1 404 1.7e-36 41 kDa zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P05049 267 5.3e-22 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF03863//PF00089 Phage maturation protein//Trypsin GO:0006508//GO:0046718 proteolysis//viral entry into host cell GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34300 BF_2 3266.44 47.96 3136 268370140 NP_001161251.1 1811 2.0e-199 uncharacterized protein LOC100141687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWK7 159 3.1e-09 RING finger protein 145 OS=Mus musculus GN=Rnf145 PE=2 SV=1 PF17123//PF12678//PF12861//PF14634//PF00097//PF11789//PF13639 RING-like zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Ring finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//metal ion binding//protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.34302 BF_2 33.24 0.34 4401 268370140 NP_001161251.1 1704 7.3e-187 uncharacterized protein LOC100141687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWK7 159 4.3e-09 RING finger protein 145 OS=Mus musculus GN=Rnf145 PE=2 SV=1 PF13639//PF11789//PF00097//PF14634//PF12861//PF17123//PF12678 Ring finger domain//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-like zinc finger//RING-H2 zinc finger GO:0016567 protein ubiquitination GO:0008270//GO:0005515//GO:0046872//GO:0004842 zinc ion binding//protein binding//metal ion binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.34303 BF_2 626.00 9.40 3072 91084169 XP_971096.1 2333 5.9e-260 PREDICTED: alpha-1,2-mannosyltransferase ALG9 [Tribolium castaneum]>gi|270006637|gb|EFA03085.1| hypothetical protein TcasGA2_TC012991 [Tribolium castaneum] -- -- -- -- -- K03846 ALG9 alpha-1,2-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03846 Q8VDI9 1411 2.0e-154 Alpha-1,2-mannosyltransferase ALG9 OS=Mus musculus GN=Alg9 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2515 Mannosyltransferase Cluster-8309.34304 BF_2 1463.03 19.01 3506 270002756 EEZ99203.1 1025 3.2e-108 serine protease P8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 670 1.9e-68 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34305 BF_2 2778.40 72.42 1892 642935333 XP_008197972.1 674 8.6e-68 PREDICTED: uncharacterized protein LOC100142013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 412 8.5e-39 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 PF02170 PAZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34307 BF_2 77.40 0.98 3582 270012466 EFA08914.1 808 4.7e-83 hypothetical protein TcasGA2_TC006619 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09618//PF05497//PF07074 CRISPR-associated protein (Cas_Csy4)//Destabilase//Translocon-associated protein, gamma subunit (TRAP-gamma) GO:0006613//GO:0043571//GO:0005975 cotranslational protein targeting to membrane//maintenance of CRISPR repeat elements//carbohydrate metabolic process GO:0004519//GO:0003796 endonuclease activity//lysozyme activity GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex -- -- Cluster-8309.34312 BF_2 2894.00 190.10 924 91093965 XP_968405.1 512 2.6e-49 PREDICTED: epididymal secretory protein E1 [Tribolium castaneum]>gi|270011130|gb|EFA07578.1| hypothetical protein TcasGA2_TC016351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61916 194 7.9e-14 Epididymal secretory protein E1 OS=Homo sapiens GN=NPC2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34315 BF_2 15.39 1.08 883 546682957 ERL92836.1 612 6.2e-61 hypothetical protein D910_10143 [Dendroctonus ponderosae] 70909478 AM048926.1 192 7.21179e-94 Biphyllus lunatus mRNA for ribosomal protein S4e (rpS4e gene) K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 613 2.0e-62 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.34316 BF_2 13812.28 59.74 9959 546672491 ERL84327.1 5266 0.0e+00 hypothetical protein D910_01746, partial [Dendroctonus ponderosae] 642918533 XM_008193290.1 175 2.37451e-83 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- O01761 764 6.8e-79 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF13897//PF02480 Immunoglobulin domain//Golgi-dynamics membrane-trafficking//Alphaherpesvirus glycoprotein E GO:0006810 transport GO:0005515 protein binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.34319 BF_2 7.07 2.01 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34320 BF_2 260.81 1.59 7147 642919008 XP_008191694.1 4125 0.0e+00 PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum]>gi|642919010|ref|XP_008191695.1| PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum] 742179525 XM_010889443.1 55 8.67913e-17 PREDICTED: Esox lucius adenylate cyclase 9 (adcy9), transcript variant X2, mRNA K08049 ADCY9 adenylate cyclase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08049 P51830 1008 2.5e-107 Adenylate cyclase type 9 OS=Mus musculus GN=Adcy9 PE=1 SV=1 PF06327//PF07701//PF00211 Domain of Unknown Function (DUF1053)//Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0006144//GO:0006171 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//purine nucleobase metabolic process//cAMP biosynthetic process GO:0004383//GO:0016849//GO:0004016 guanylate cyclase activity//phosphorus-oxygen lyase activity//adenylate cyclase activity GO:0005886 plasma membrane KOG3618 Adenylyl cyclase Cluster-8309.34321 BF_2 10460.17 42.35 10619 642913459 XP_008201021.1 2877 0.0e+00 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 192 8.98037e-93 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 1068 4.1e-114 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF03334//PF03581//PF03169 Na+/H+ antiporter subunit//Herpesvirus UL33-like protein//OPT oligopeptide transporter protein GO:0015672//GO:0055085//GO:0015992//GO:0019073 monovalent inorganic cation transport//transmembrane transport//proton transport//viral DNA genome packaging GO:0005451 monovalent cation:proton antiporter activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.34322 BF_2 711.85 42.07 995 642915041 XP_008190385.1 562 4.4e-55 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like [Tribolium castaneum] -- -- -- -- -- K08059 IFI30, GILT interferon, gamma-inducible protein 30 http://www.genome.jp/dbget-bin/www_bget?ko:K08059 A6QPN6 281 6.9e-24 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.34323 BF_2 260.20 6.16 2053 189240075 XP_001812636.1 1261 8.0e-136 PREDICTED: protein singed wings 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SXT3 593 9.5e-60 Protein singed wings 2 OS=Drosophila melanogaster GN=swi2 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34326 BF_2 2.00 5.77 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34329 BF_2 2316.00 72.20 1629 642935043 XP_969003.2 1763 3.9e-194 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit [Tribolium castaneum] -- -- -- -- -- K12670 WBP1 oligosaccharyltransferase complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12670 Q24319 1462 1.3e-160 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit OS=Drosophila melanogaster GN=Ost48 PE=2 SV=2 PF03345 Oligosaccharyltransferase 48 kDa subunit beta GO:0018279 protein N-linked glycosylation via asparagine -- -- GO:0005789 endoplasmic reticulum membrane KOG2754 Oligosaccharyltransferase, beta subunit Cluster-8309.34330 BF_2 119.20 2.87 2027 14028771 AAK52496.1 146 1.5e-06 chymotrypsin inhibitor CI-b1 [Bombyx mori] -- -- -- -- -- -- -- -- -- P10832 146 6.4e-08 Chymotrypsin inhibitor SCI-II OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34331 BF_2 5329.73 57.64 4155 642924423 XP_008194290.1 636 4.8e-63 PREDICTED: actin-binding Rho-activating protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N0Z2 271 4.2e-22 Actin-binding Rho-activating protein OS=Homo sapiens GN=ABRA PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3376 Uncharacterized conserved protein Cluster-8309.34335 BF_2 586.39 10.25 2680 91077358 XP_975083.1 383 6.8e-34 PREDICTED: protein spaetzle isoform X2 [Tribolium castaneum]>gi|642913850|ref|XP_008201187.1| PREDICTED: protein spaetzle isoform X1 [Tribolium castaneum]>gi|642913852|ref|XP_008201188.1| PREDICTED: protein spaetzle isoform X1 [Tribolium castaneum]>gi|270002760|gb|EEZ99207.1| spaetzle [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48607 219 2.9e-16 Protein spaetzle OS=Drosophila melanogaster GN=spz PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34336 BF_2 100.13 2.62 1885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34337 BF_2 7.06 0.81 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34339 BF_2 5.76 0.34 991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34343 BF_2 30.00 0.52 2696 270011663 EFA08111.1 1349 6.6e-146 hypothetical protein TcasGA2_TC005715 [Tribolium castaneum] 642932090 XM_970041.3 512 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 5 activator 1 (LOC664019), mRNA K11716 CDK5R1 cyclin-dependent kinase 5 activator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11716 Q28199 573 2.6e-57 Cyclin-dependent kinase 5 activator 1 OS=Bos taurus GN=CDK5R1 PE=1 SV=1 PF03261 Cyclin-dependent kinase 5 activator protein GO:0045859 regulation of protein kinase activity GO:0016534 cyclin-dependent protein kinase 5 activator activity GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex KOG3932 CDK5 kinase activator p35/Nck5a Cluster-8309.34345 BF_2 404.34 5.86 3172 642929001 XP_008195650.1 2752 1.6e-308 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 999 1.2e-106 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF05986//PF08686 ADAM-TS Spacer 1//PLAC (protease and lacunin) domain -- -- GO:0004222//GO:0008233 metalloendopeptidase activity//peptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.34347 BF_2 256.62 1.65 6812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00894//PF00641 Luteovirus coat protein//Zn-finger in Ran binding protein and others -- -- GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.34348 BF_2 448.00 10.82 2020 189239065 XP_971190.2 918 4.7e-96 PREDICTED: putative phosphatidate phosphatase isoform X1 [Tribolium castaneum]>gi|270010853|gb|EFA07301.1| hypothetical protein TcasGA2_TC015891 [Tribolium castaneum] 817069832 XM_012401489.1 36 8.84467e-07 PREDICTED: Athalia rosae putative phosphatidate phosphatase (LOC105686556), mRNA K01080 PPAP2 phosphatidate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01080 Q9V576 693 2.4e-71 Putative phosphatidate phosphatase OS=Drosophila melanogaster GN=wun PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3030 Lipid phosphate phosphatase and related enzymes of the PAP2 family Cluster-8309.34349 BF_2 500.00 51.16 696 332372472 AEE61378.1 708 3.6e-72 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00020 E1.1.1.31, mmsB 3-hydroxyisobutyrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00020 P31937 596 1.4e-60 3-hydroxyisobutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=HIBADH PE=1 SV=2 PF14833//PF03446 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0006098//GO:0019521 oxidation-reduction process//pentose-phosphate shunt//D-gluconate metabolic process GO:0051287//GO:0004616 NAD binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG0409 Predicted dehydrogenase Cluster-8309.34350 BF_2 3108.90 133.55 1261 189241537 XP_970292.2 1695 2.3e-186 PREDICTED: tropomodulin isoform X2 [Tribolium castaneum] 642936890 XR_511484.1 397 0 PREDICTED: Tribolium castaneum tropomodulin (LOC658846), transcript variant X2, misc_RNA K10370 TMOD tropomodulin http://www.genome.jp/dbget-bin/www_bget?ko:K10370 O01479 645 5.4e-66 Tropomodulin OS=Caenorhabditis elegans GN=unc-94 PE=1 SV=2 PF03250 Tropomodulin GO:0051694 pointed-end actin filament capping GO:0005523 tropomyosin binding -- -- KOG3735 Tropomodulin and leiomodulin Cluster-8309.34351 BF_2 11.00 0.35 1611 478256469 ENN76654.1 207 1.0e-13 hypothetical protein YQE_06833, partial [Dendroctonus ponderosae] -- -- -- -- -- K10370 TMOD tropomodulin http://www.genome.jp/dbget-bin/www_bget?ko:K10370 -- -- -- -- PF09326 NADH-ubiquinone oxidoreductase subunit G, C-terminal GO:0055114 oxidation-reduction process GO:0051536//GO:0016651 iron-sulfur cluster binding//oxidoreductase activity, acting on NAD(P)H -- -- -- -- Cluster-8309.34354 BF_2 1375.84 6.26 9474 642922513 XP_008193205.1 10415 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase hyd isoform X4 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.424e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1848 1.3e-204 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF04625//PF00658//PF00632//PF11547 DEC-1 protein, N-terminal region//Poly-adenylate binding protein, unique domain//HECT-domain (ubiquitin-transferase)//E3 ubiquitin ligase EDD GO:0007304//GO:0016567 chorion-containing eggshell formation//protein ubiquitination GO:0043130//GO:0005213//GO:0003723//GO:0004842 ubiquitin binding//structural constituent of chorion//RNA binding//ubiquitin-protein transferase activity GO:0005576//GO:0042600 extracellular region//chorion KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.34355 BF_2 1473.54 31.58 2239 642923934 XP_969778.3 1124 6.7e-120 PREDICTED: choline-phosphate cytidylyltransferase A-like isoform X2 [Tribolium castaneum]>gi|270006886|gb|EFA03334.1| hypothetical protein TcasGA2_TC013311 [Tribolium castaneum] -- -- -- -- -- K00968 PCYT1 choline-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00968 P49585 756 1.3e-78 Choline-phosphate cytidylyltransferase A OS=Homo sapiens GN=PCYT1A PE=1 SV=2 PF06574//PF01467 FAD synthetase//Cytidylyltransferase-like GO:0009058//GO:0009231//GO:0006771 biosynthetic process//riboflavin biosynthetic process//riboflavin metabolic process GO:0003919//GO:0003824 FMN adenylyltransferase activity//catalytic activity -- -- KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.34357 BF_2 216.56 17.60 802 642932804 XP_008196990.1 639 4.2e-64 PREDICTED: myosin heavy chain, non-muscle isoform X1 [Tribolium castaneum] -- -- -- -- -- K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 444 7.0e-43 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF00063//PF02736 Myosin head (motor domain)//Myosin N-terminal SH3-like domain -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.34358 BF_2 910.36 8.36 4845 91084547 XP_973113.1 3577 0.0e+00 PREDICTED: protein unc-45 homolog B [Tribolium castaneum]>gi|270009248|gb|EFA05696.1| translocase of outer membrane 34 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F64 1674 1.0e-184 Protein unc-45 homolog B OS=Xenopus laevis GN=unc45b PE=2 SV=1 PF00515//PF13374//PF13371//PF08718//PF03152//PF13176//PF13414//PF13181//PF00839//PF00514 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Glycolipid transfer protein (GLTP)//Ubiquitin fusion degradation protein UFD1//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Cysteine rich repeat//Armadillo/beta-catenin-like repeat GO:0046836//GO:0006511 glycolipid transport//ubiquitin-dependent protein catabolic process GO:0005515//GO:0051861//GO:0017089 protein binding//glycolipid binding//glycolipid transporter activity GO:0005737//GO:0016020 cytoplasm//membrane KOG1816 Ubiquitin fusion-degradation protein Cluster-8309.34359 BF_2 1181.52 55.54 1177 820805538 AKG92760.1 637 1.0e-63 extra macrochaetae [Leptinotarsa decemlineata] 195428687 XM_002062365.1 43 6.53595e-11 Drosophila willistoni GK17519 (Dwil\GK17519), mRNA K17696 EMC DNA-binding protein inhibitor ID, other http://www.genome.jp/dbget-bin/www_bget?ko:K17696 P18491 259 2.9e-21 Protein extra-macrochaetae OS=Drosophila melanogaster GN=emc PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.34361 BF_2 124.75 1.37 4103 91085815 XP_974770.1 991 3.3e-104 PREDICTED: maternal protein exuperantia-1 [Tribolium castaneum]>gi|270011046|gb|EFA07494.1| exuperantia [Tribolium castaneum] -- -- -- -- -- K18745 EXU maternal protein exuperantia http://www.genome.jp/dbget-bin/www_bget?ko:K18745 P28750 459 6.5e-44 Maternal protein exuperantia OS=Drosophila melanogaster GN=exu PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34363 BF_2 17.81 0.48 1827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34364 BF_2 337.38 8.39 1969 478258333 ENN78452.1 1152 3.3e-123 hypothetical protein YQE_05090, partial [Dendroctonus ponderosae]>gi|546677055|gb|ERL87964.1| hypothetical protein D910_05352 [Dendroctonus ponderosae] 197259972 EU921225.1 117 8.08585e-52 Thermonectus marmoratus putative long wavelength opsin mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q17292 1006 1.2e-107 Rhodopsin OS=Camponotus atriceps PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.34368 BF_2 7415.62 39.15 8211 642925096 XP_008194167.1 6812 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925095 XM_008195945.1 465 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X1, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q0JKD0 4214 0.0e+00 Glutamate synthase 1 [NADH], chloroplastic OS=Oryza sativa subsp. japonica GN=Os01g0681900 PE=2 SV=1 PF05834//PF13241//PF01134//PF00869//PF01494//PF00287//PF07992//PF01645//PF01266//PF01210//PF01493//PF00070//PF01070//PF04898//PF00743//PF12831//PF01593 Lycopene cyclase protein//Putative NAD(P)-binding//Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//FAD binding domain//Sodium / potassium ATPase beta chain//Pyridine nucleotide-disulphide oxidoreductase//Conserved region in glutamate synthase//FAD dependent oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase GO:0006537//GO:0006814//GO:0055114//GO:0008033//GO:0006779//GO:0019354//GO:0008152//GO:0046168//GO:0006813//GO:0016117//GO:0006807 glutamate biosynthetic process//sodium ion transport//oxidation-reduction process//tRNA processing//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process//metabolic process//glycerol-3-phosphate catabolic process//potassium ion transport//carotenoid biosynthetic process//nitrogen compound metabolic process GO:0071949//GO:0016616//GO:0016638//GO:0016705//GO:0050661//GO:0004499//GO:0043115//GO:0051287//GO:0046983//GO:0016491//GO:0050660//GO:0015930 FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the CH-NH2 group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//N,N-dimethylaniline monooxygenase activity//precorrin-2 dehydrogenase activity//NAD binding//protein dimerization activity//oxidoreductase activity//flavin adenine dinucleotide binding//glutamate synthase activity GO:0005890 sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.34369 BF_2 68.95 0.35 8555 642925096 XP_008194167.1 6812 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925099 XM_964960.2 404 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9C102 4214 0.0e+00 Putative glutamate synthase [NADPH] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=glt1 PE=2 SV=1 PF01645//PF01266//PF01210//PF01493//PF00070//PF01070//PF04898//PF00743//PF01593//PF12831//PF13241//PF05834//PF01134//PF00869//PF01494//PF00287//PF07992 Conserved region in glutamate synthase//FAD dependent oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Lycopene cyclase protein//Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//FAD binding domain//Sodium / potassium ATPase beta chain//Pyridine nucleotide-disulphide oxidoreductase GO:0006813//GO:0019354//GO:0008152//GO:0046168//GO:0006807//GO:0016117//GO:0006537//GO:0055114//GO:0006779//GO:0008033//GO:0006814 potassium ion transport//siroheme biosynthetic process//metabolic process//glycerol-3-phosphate catabolic process//nitrogen compound metabolic process//carotenoid biosynthetic process//glutamate biosynthetic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//tRNA processing//sodium ion transport GO:0051287//GO:0046983//GO:0016491//GO:0016705//GO:0050661//GO:0043115//GO:0004499//GO:0015930//GO:0050660//GO:0016616//GO:0071949//GO:0016638 NAD binding//protein dimerization activity//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//precorrin-2 dehydrogenase activity//N,N-dimethylaniline monooxygenase activity//glutamate synthase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//FAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0005890 sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.34371 BF_2 709.72 3.38 9069 478260541 ENN80244.1 792 8.6e-81 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 1.80618e-29 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q9TSM6 517 2.7e-50 Protein tyrosine phosphatase type IVA 1 OS=Macaca fascicularis GN=PTP4A1 PE=1 SV=1 PF00782//PF01686//PF15750//PF00102 Dual specificity phosphatase, catalytic domain//Adenovirus penton base protein//Ubiquitin-binding zinc-finger//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0005198//GO:0008138//GO:0004725//GO:0043130 structural molecule activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//ubiquitin binding -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.34372 BF_2 42.60 2.30 1063 -- -- -- -- -- 642911796 XM_008202524.1 77 7.40796e-30 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34374 BF_2 558.64 2.34 10292 546685894 ERL95319.1 1919 2.0e-211 hypothetical protein D910_12585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MSS1 515 5.3e-50 Protein lava lamp OS=Drosophila melanogaster GN=lva PE=1 SV=2 PF06463//PF10186 Molybdenum Cofactor Synthesis C//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006777//GO:0010508 Mo-molybdopterin cofactor biosynthetic process//positive regulation of autophagy GO:0051539 4 iron, 4 sulfur cluster binding GO:0019008 molybdopterin synthase complex KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.34375 BF_2 32.63 1.01 1645 749749799 XP_011137128.1 258 1.3e-19 PREDICTED: inducible metalloproteinase inhibitor protein-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P82176 207 4.4e-15 Inducible metalloproteinase inhibitor protein OS=Galleria mellonella GN=IMPI PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34376 BF_2 60.37 1.00 2812 91084625 XP_974579.1 1191 1.4e-127 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 638 7.9e-65 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.34377 BF_2 29.79 0.48 2891 91084625 XP_974579.1 1191 1.5e-127 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 638 8.1e-65 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.34378 BF_2 1041.49 31.88 1654 478252070 ENN72501.1 1998 2.2e-221 hypothetical protein YQE_10842, partial [Dendroctonus ponderosae] 768414731 XM_011549582.1 84 1.49663e-33 PREDICTED: Plutella xylostella uncharacterized LOC105380086 (LOC105380086), mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q9D4H8 1432 3.9e-157 Cullin-2 OS=Mus musculus GN=Cul2 PE=1 SV=2 PF08469//PF00888 Nucleoside triphosphatase I C-terminal//Cullin family GO:0006351//GO:0006511 transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0005524//GO:0017111 ubiquitin protein ligase binding//ATP binding//nucleoside-triphosphatase activity -- -- KOG2166 Cullins Cluster-8309.34379 BF_2 10.34 0.43 1298 642934319 XP_008198599.1 370 1.1e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34380 BF_2 7678.66 196.48 1922 332376935 AEE63607.1 1628 2.1e-178 unknown [Dendroctonus ponderosae]>gi|478259710|gb|ENN79554.1| hypothetical protein YQE_04016, partial [Dendroctonus ponderosae]>gi|546676265|gb|ERL87311.1| hypothetical protein D910_04706 [Dendroctonus ponderosae] 758206659 XM_011327360.1 36 8.40801e-07 Fusarium graminearum PH-1 aspartate aminotransferase partial mRNA K14454 GOT1 aspartate aminotransferase, cytoplasmic http://www.genome.jp/dbget-bin/www_bget?ko:K14454 P13221 1240 8.4e-135 Aspartate aminotransferase, cytoplasmic OS=Rattus norvegicus GN=Got1 PE=1 SV=3 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.34381 BF_2 664.71 3.39 8496 91083999 XP_975264.1 1320 4.8e-142 PREDICTED: protein FAM13A [Tribolium castaneum]>gi|270006707|gb|EFA03155.1| hypothetical protein TcasGA2_TC013074 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYW0 267 2.5e-21 Protein FAM13A OS=Bos taurus GN=FAM13A PE=2 SV=1 PF11365 Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy -- -- GO:0005615 extracellular space -- -- Cluster-8309.34382 BF_2 55.00 9.43 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34383 BF_2 645.99 16.37 1938 646723788 KDR24282.1 1204 3.1e-129 Serine hydroxymethyltransferase, cytosolic [Zootermopsis nevadensis] 242024281 XM_002432512.1 73 2.29178e-27 Pediculus humanus corporis serine hydroxymethyltransferase, cytosolic, putative, mRNA K00600 glyA, SHMT glycine hydroxymethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00600 P34896 1024 9.4e-110 Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens GN=SHMT1 PE=1 SV=1 PF00464 Serine hydroxymethyltransferase -- -- GO:0016740 transferase activity -- -- KOG2467 Glycine/serine hydroxymethyltransferase Cluster-8309.34384 BF_2 369.06 13.22 1455 642933530 XP_008197457.1 904 1.4e-94 PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933532|ref|XP_008197458.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum]>gi|642933534|ref|XP_008197459.1| PREDICTED: protein alan shepard isoform X5 [Tribolium castaneum] 462283408 APGK01056946.1 55 1.73447e-17 Dendroctonus ponderosae Seq01056956, whole genome shotgun sequence -- -- -- -- B4KX02 750 4.2e-78 Protein alan shepard OS=Drosophila mojavensis GN=shep PE=3 SV=1 PF09726//PF01080//PF07267//PF00076 Transmembrane protein//Presenilin//Nucleopolyhedrovirus capsid protein P87//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4733 FOG: RRM domain Cluster-8309.34386 BF_2 214.00 12.83 985 91091618 XP_969683.1 307 1.6e-25 PREDICTED: receptor-binding cancer antigen expressed on SiSo cells [Tribolium castaneum]>gi|270000900|gb|EEZ97347.1| hypothetical protein TcasGA2_TC011163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34387 BF_2 117.00 5.69 1147 270008456 EFA04904.1 572 3.5e-56 hypothetical protein TcasGA2_TC014968 [Tribolium castaneum] -- -- -- -- -- K13206 CCDC55 coiled-coil domain-containing protein 55 http://www.genome.jp/dbget-bin/www_bget?ko:K13206 Q568R1 273 6.8e-23 Nuclear speckle splicing regulatory protein 1 OS=Danio rerio GN=nsrp1 PE=1 SV=2 PF10717//PF02950 Occlusion-derived virus envelope protein ODV-E18//Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576//GO:0019031 extracellular region//viral envelope KOG2117 Uncharacterized conserved protein Cluster-8309.34388 BF_2 195.00 6.86 1476 859132827 AKO63324.1 1340 4.0e-145 geranylgeranyl pyrophosphate synthase [Leptinotarsa decemlineata] -- -- -- -- -- K00804 GGPS1 geranylgeranyl diphosphate synthase, type III http://www.genome.jp/dbget-bin/www_bget?ko:K00804 P56966 949 3.6e-101 Geranylgeranyl pyrophosphate synthase OS=Bos taurus GN=GGPS1 PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.34389 BF_2 1085.74 16.29 3075 189237987 XP_001812710.1 3253 0.0e+00 PREDICTED: solute carrier family 12 member 9 [Tribolium castaneum] 632984903 XM_007911190.1 52 1.72649e-15 PREDICTED: Callorhinchus milii solute carrier family 12, member 9 (slc12a9), mRNA K14429 SLC12A9, CCC6 solute carrier family 12 (potassium/chloride transporters), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14429 A2BFP5 1750 9.8e-194 Solute carrier family 12 member 9 OS=Danio rerio GN=slc12a9 PE=3 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006810//GO:0006811//GO:0055085 transport//ion transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG1288 Amino acid transporters Cluster-8309.34391 BF_2 427.94 3.10 6063 91086459 XP_969641.1 1106 2.2e-117 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 P57093 721 4.0e-74 Phytanoyl-CoA dioxygenase, peroxisomal OS=Rattus norvegicus GN=Phyh PE=1 SV=2 PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.34393 BF_2 63.39 0.75 3832 478250074 ENN70580.1 978 9.8e-103 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 95 2.69272e-39 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.6e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF08030//PF00175//PF02294 Ferric reductase NAD binding domain//Oxidoreductase NAD-binding domain//7kD DNA-binding domain GO:0051252//GO:0055114 regulation of RNA metabolic process//oxidation-reduction process GO:0004521//GO:0016491//GO:0003677 endoribonuclease activity//oxidoreductase activity//DNA binding -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.34396 BF_2 103.94 1.22 3862 189236750 XP_975130.2 1692 1.6e-185 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 491 1.2e-47 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.34399 BF_2 477.07 7.19 3064 270002486 EEZ98933.1 3164 0.0e+00 hypothetical protein TcasGA2_TC004554 [Tribolium castaneum] 749758627 XM_011142875.1 143 4.45624e-66 PREDICTED: Harpegnathos saltator furin-like protease 2 (LOC105184226), transcript variant X4, mRNA -- -- -- -- P30432 1916 5.5e-213 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00757//PF01483 Furin-like cysteine rich region//Proprotein convertase P-domain GO:0006508//GO:0007169//GO:0006468 proteolysis//transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0004714//GO:0004252 ATP binding//transmembrane receptor protein tyrosine kinase activity//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.34401 BF_2 584.00 5.94 4397 642921623 XP_008192451.1 1982 4.3e-219 PREDICTED: WD repeat-containing protein 6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NNW5 648 8.5e-66 WD repeat-containing protein 6 OS=Homo sapiens GN=WDR6 PE=1 SV=1 PF00400//PF02932//PF07569 WD domain, G-beta repeat//Neurotransmitter-gated ion-channel transmembrane region//TUP1-like enhancer of split GO:0006811//GO:0006355 ion transport//regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016020 nucleus//membrane KOG3113 Uncharacterized conserved protein Cluster-8309.34407 BF_2 264.81 8.94 1526 646710939 KDR16317.1 278 5.8e-22 Eukaryotic translation initiation factor 3 subunit G [Zootermopsis nevadensis] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q9VDM6 248 7.1e-20 Eukaryotic translation initiation factor 3 subunit G-2 OS=Drosophila melanogaster GN=eIF3-S4-2 PE=3 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.34408 BF_2 4831.73 187.70 1364 91080821 XP_966682.1 378 1.3e-33 PREDICTED: uncharacterized protein LOC658984 [Tribolium castaneum]>gi|270005906|gb|EFA02354.1| hypothetical protein TcasGA2_TC008024 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EF78 144 7.3e-08 Icarapin OS=Apis mellifera carnica PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34410 BF_2 1902.41 12.62 6594 642911773 XP_008200735.1 2345 5.2e-261 PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911775|ref|XP_008200736.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911777|ref|XP_008200737.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911779|ref|XP_008200738.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|270014735|gb|EFA11183.1| hypothetical protein TcasGA2_TC004791 [Tribolium castaneum] 397560823 JX204291.1 38 2.25715e-07 Sogatella furcifera membrane-bound trehalase mRNA, complete cds K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 A8J4S9 1814 8.0e-201 Trehalase OS=Apis mellifera PE=1 SV=1 PF01204 Trehalase GO:0005991//GO:0005982//GO:0005985 trehalose metabolic process//starch metabolic process//sucrose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.34411 BF_2 4253.63 60.49 3229 546676114 ERL87181.1 3057 0.0e+00 hypothetical protein D910_04581 [Dendroctonus ponderosae] 642913385 XM_964220.3 357 0 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q9H8M5 1371 9.1e-150 Metal transporter CNNM2 OS=Homo sapiens GN=CNNM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.34412 BF_2 98.12 1.26 3541 546676114 ERL87181.1 2895 0.0e+00 hypothetical protein D910_04581 [Dendroctonus ponderosae] 642913385 XM_964220.3 344 9.48891e-178 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q9H8M5 1369 1.7e-149 Metal transporter CNNM2 OS=Homo sapiens GN=CNNM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.34413 BF_2 845.57 18.65 2184 478250402 ENN70897.1 2544 1.4e-284 hypothetical protein YQE_12302, partial [Dendroctonus ponderosae] 751219340 XM_011164448.1 192 1.82489e-93 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 2023 1.5e-225 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.34414 BF_2 428.65 8.37 2429 642923254 XP_008193679.1 700 1.1e-70 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.4e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF03796//PF00154 DnaB-like helicase C terminal domain//recA bacterial DNA recombination protein GO:0009432//GO:0006260//GO:0006281 SOS response//DNA replication//DNA repair GO:0003697//GO:0003678//GO:0005524 single-stranded DNA binding//DNA helicase activity//ATP binding GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.34416 BF_2 4986.75 29.99 7243 642934807 XP_008197818.1 2312 3.8e-257 PREDICTED: ninein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I6 514 4.8e-50 Ninein-like protein OS=Homo sapiens GN=NINL PE=1 SV=2 PF00170//PF04977//PF13405//PF13499//PF15070//PF04479//PF01176//PF10473//PF05837 bZIP transcription factor//Septum formation initiator//EF-hand domain//EF-hand domain pair//Putative golgin subfamily A member 2-like protein 5//RTA1 like protein//Translation initiation factor 1A / IF-1//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H) GO:0051382//GO:0007049//GO:0006355//GO:0006446//GO:0006950//GO:0006413 kinetochore assembly//cell cycle//regulation of transcription, DNA-templated//regulation of translational initiation//response to stress//translational initiation GO:0008134//GO:0045502//GO:0003743//GO:0003700//GO:0043565//GO:0003723//GO:0005509//GO:0042803 transcription factor binding//dynein binding//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//RNA binding//calcium ion binding//protein homodimerization activity GO:0005794//GO:0016021//GO:0005840//GO:0005667//GO:0030286//GO:0000776 Golgi apparatus//integral component of membrane//ribosome//transcription factor complex//dynein complex//kinetochore -- -- Cluster-8309.34417 BF_2 4026.30 70.39 2680 642934807 XP_008197818.1 1734 1.5e-190 PREDICTED: ninein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11929 237 2.4e-18 Blastoderm-specific protein 25D OS=Drosophila melanogaster GN=Bsg25D PE=1 SV=2 PF00170//PF06005 bZIP transcription factor//Protein of unknown function (DUF904) GO:0043093//GO:0000917//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.34419 BF_2 412.39 2.88 6283 189241799 XP_970228.2 3095 0.0e+00 PREDICTED: inverted formin-2 [Tribolium castaneum]>gi|270001160|gb|EEZ97607.1| hypothetical protein TcasGA2_TC011477 [Tribolium castaneum] 642925592 XM_008196391.1 434 0 PREDICTED: Tribolium castaneum uncharacterized LOC658801 (LOC658801), mRNA -- -- -- -- Q9C0D6 714 2.7e-73 FH2 domain-containing protein 1 OS=Homo sapiens GN=FHDC1 PE=1 SV=2 PF06367//PF06371 Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0030036//GO:0016043 actin cytoskeleton organization//cellular component organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.3442 BF_2 3.00 0.55 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34420 BF_2 1833.81 61.13 1542 91086669 XP_968223.1 832 3.4e-86 PREDICTED: proteasomal ubiquitin receptor ADRM1 [Tribolium castaneum]>gi|270010393|gb|EFA06841.1| hypothetical protein TcasGA2_TC009784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NZ09 579 3.0e-58 Proteasomal ubiquitin receptor ADRM1 OS=Danio rerio GN=adrm1b PE=1 SV=1 PF04683 Proteasome complex subunit Rpn13 ubiquitin receptor -- -- -- -- GO:0005634//GO:0005737 nucleus//cytoplasm KOG3037 Cell membrane glycoprotein Cluster-8309.34423 BF_2 1131.22 11.79 4302 642912316 XP_969236.2 2540 8.3e-284 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZW8 1281 3.3e-139 NHL repeat-containing protein 2 OS=Mus musculus GN=Nhlrc2 PE=2 SV=1 PF01731//PF00085//PF01436 Arylesterase//Thioredoxin//NHL repeat GO:0045454 cell redox homeostasis GO:0004064//GO:0005515 arylesterase activity//protein binding -- -- -- -- Cluster-8309.34425 BF_2 252.18 3.79 3069 642923795 XP_008193886.1 1531 5.9e-167 PREDICTED: uncharacterized protein LOC663689 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07650//PF13014//PF04999//PF00013 KH domain//KH domain//Cell division protein FtsL//KH domain GO:0051301//GO:0007049 cell division//cell cycle GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.34427 BF_2 2300.00 52.41 2123 478250669 ENN71161.1 1170 3.0e-125 hypothetical protein YQE_12091, partial [Dendroctonus ponderosae]>gi|546677253|gb|ERL88122.1| hypothetical protein D910_05510 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI23 736 2.6e-76 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34429 BF_2 7.00 0.75 677 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3443 BF_2 1.00 0.38 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34430 BF_2 22.23 0.38 2713 642912447 XP_008200864.1 229 4.9e-16 PREDICTED: LOW QUALITY PROTEIN: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.34431 BF_2 325.43 10.65 1565 91094739 XP_971002.1 702 4.0e-71 PREDICTED: uncharacterized protein LOC659618 [Tribolium castaneum]>gi|270010786|gb|EFA07234.1| hypothetical protein TcasGA2_TC010591 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BN57 213 8.4e-16 Protein C3orf33 homolog OS=Mus musculus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34435 BF_2 303.05 1.79 7386 642930106 XP_008196254.1 2024 9.7e-224 PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum]>gi|642930108|ref|XP_008196255.1| PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum] 686207191 AP014521.1 40 1.95564e-08 Candidatus Tachikawaea gelatinosa DNA, complete genome K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q96HY7 1540 5.3e-169 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Homo sapiens GN=DHTKD1 PE=1 SV=2 PF09412//PF00676 Endoribonuclease XendoU//Dehydrogenase E1 component GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.34436 BF_2 16.37 1.66 699 264667337 ACY71254.1 443 1.9e-41 ribosomal protein L11 [Chrysomela tremula] 769837621 XM_011631699.1 104 4.68692e-45 PREDICTED: Pogonomyrmex barbatus 60S ribosomal protein L11-like (LOC105422357), mRNA K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P46222 440 1.8e-42 60S ribosomal protein L11 OS=Drosophila melanogaster GN=RpL11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-8309.34440 BF_2 89.22 0.83 4764 646704092 KDR12447.1 965 3.9e-101 Autophagy-related protein 13-like protein [Zootermopsis nevadensis] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 Q9VHR6 650 5.4e-66 Autophagy-related protein 13 homolog OS=Drosophila melanogaster GN=Atg13 PE=1 SV=1 PF09452//PF06667 ESCRT-I subunit Mvb12//Phage shock protein B GO:0006355//GO:0009271//GO:0032509 regulation of transcription, DNA-templated//phage shock//endosome transport via multivesicular body sorting pathway GO:0043130 ubiquitin binding GO:0000813 ESCRT I complex KOG3874 Uncharacterized conserved protein Cluster-8309.34443 BF_2 3.00 0.45 568 642915081 XP_008190403.1 242 3.2e-18 PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|642915083|ref|XP_008190404.1| PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|270002357|gb|EEZ98804.1| hypothetical protein TcasGA2_TC001374 [Tribolium castaneum] -- -- -- -- -- K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q9NHW7 193 6.3e-14 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.34444 BF_2 123.86 3.19 1910 478255591 ENN75805.1 2200 9.8e-245 hypothetical protein YQE_07641, partial [Dendroctonus ponderosae]>gi|546682293|gb|ERL92251.1| hypothetical protein D910_09568 [Dendroctonus ponderosae] 704290140 XM_010177591.1 138 1.66125e-63 PREDICTED: Caprimulgus carolinensis SNW domain containing 1 (SNW1), partial mRNA K06063 SNW1, SKIIP, SKIP SNW domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06063 P39736 1642 2.0e-181 Puff-specific protein Bx42 OS=Drosophila melanogaster GN=Bx42 PE=1 SV=1 PF02841//PF02731 Guanylate-binding protein, C-terminal domain//SKIP/SNW domain GO:0000398 mRNA splicing, via spliceosome GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005681 spliceosomal complex KOG2441 mRNA splicing factor/probable chromatin binding snw family nuclear protein Cluster-8309.34446 BF_2 1.00 0.67 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34447 BF_2 162.52 0.83 8508 642918656 XP_008191524.1 2229 1.9e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.2e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00433//PF01799//PF07714//PF00069//PF00463//PF07535//PF06220 Protein kinase C terminal domain//[2Fe-2S] binding domain//Protein tyrosine kinase//Protein kinase domain//Isocitrate lyase family//DBF zinc finger//U1 zinc finger GO:0019752//GO:0016310//GO:0009069//GO:0006468//GO:0006097//GO:0055114 carboxylic acid metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//glyoxylate cycle//oxidation-reduction process GO:0005524//GO:0016491//GO:0004451//GO:0005543//GO:0003676//GO:0008270//GO:0004672//GO:0046872//GO:0004674 ATP binding//oxidoreductase activity//isocitrate lyase activity//phospholipid binding//nucleic acid binding//zinc ion binding//protein kinase activity//metal ion binding//protein serine/threonine kinase activity -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.34449 BF_2 670.70 8.84 3461 642914288 XP_008201623.1 1679 4.6e-184 PREDICTED: ubiquitin-conjugating enzyme E2 Q2 [Tribolium castaneum] -- -- -- -- -- K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q7TSS2 992 8.7e-106 Ubiquitin-conjugating enzyme E2 Q1 OS=Mus musculus GN=Ube2q1 PE=1 SV=2 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.3445 BF_2 2.00 0.36 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34450 BF_2 298.38 7.01 2067 642913818 XP_008201172.1 643 3.7e-64 PREDICTED: myosin light chain alkali isoform X1 [Tribolium castaneum] 642913817 XM_008202950.1 253 2.12427e-127 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 449 4.8e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF13405//PF00036 EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.34451 BF_2 58.07 2.10 1442 642929884 XP_008196012.1 683 5.9e-69 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 214 5.9e-16 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.34452 BF_2 608.77 20.95 1503 91083361 XP_975131.1 976 6.6e-103 PREDICTED: protein slowmo [Tribolium castaneum]>gi|270007772|gb|EFA04220.1| hypothetical protein TcasGA2_TC014470 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3U9 785 3.8e-82 Protein slowmo OS=Drosophila melanogaster GN=slmo PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3336 Predicted member of the intramitochondrial sorting protein family Cluster-8309.34453 BF_2 1381.03 18.29 3445 642914288 XP_008201623.1 1693 1.1e-185 PREDICTED: ubiquitin-conjugating enzyme E2 Q2 [Tribolium castaneum] -- -- -- -- -- K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q7TSS2 988 2.5e-105 Ubiquitin-conjugating enzyme E2 Q1 OS=Mus musculus GN=Ube2q1 PE=1 SV=2 PF07973//PF05773 Threonyl and Alanyl tRNA synthetase second additional domain//RWD domain GO:0043039 tRNA aminoacylation GO:0005524//GO:0016876//GO:0005515 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//protein binding -- -- KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.34454 BF_2 16.53 0.33 2403 642914288 XP_008201623.1 387 2.1e-34 PREDICTED: ubiquitin-conjugating enzyme E2 Q2 [Tribolium castaneum] -- -- -- -- -- K10582 UBE2Q ubiquitin-conjugating enzyme E2 Q http://www.genome.jp/dbget-bin/www_bget?ko:K10582 Q7Z7E8 314 2.5e-27 Ubiquitin-conjugating enzyme E2 Q1 OS=Homo sapiens GN=UBE2Q1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0897 Predicted ubiquitin-conjugating enzyme Cluster-8309.34456 BF_2 1208.91 75.50 957 91076150 XP_970566.1 886 1.1e-92 PREDICTED: transmembrane protein 205 [Tribolium castaneum]>gi|270014570|gb|EFA11018.1| hypothetical protein TcasGA2_TC004605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GPW4 198 2.8e-14 Transmembrane protein 205 OS=Xenopus laevis GN=tmem205 PE=2 SV=1 PF05374 Mu-Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG2886 Uncharacterized conserved protein Cluster-8309.34457 BF_2 20.09 0.83 1304 478260563 ENN80266.1 426 3.4e-39 hypothetical protein YQE_03260, partial [Dendroctonus ponderosae]>gi|546685301|gb|ERL94828.1| hypothetical protein D910_12101 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GPW4 141 1.6e-07 Transmembrane protein 205 OS=Xenopus laevis GN=tmem205 PE=2 SV=1 PF05374 Mu-Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region KOG2886 Uncharacterized conserved protein Cluster-8309.34458 BF_2 449.98 7.66 2745 861649070 KMQ96644.1 2150 8.8e-239 tyrosine-protein phosphatase non-receptor type 4 [Lasius niger] 817186761 XM_012432473.1 150 5.12086e-70 PREDICTED: Orussus abietinus tyrosine-protein phosphatase non-receptor type 4 (LOC105703795), transcript variant X5, mRNA K18037 PTPN4, MEG tyrosine-protein phosphatase non-receptor type 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18037 Q9WU22 1000 8.1e-107 Tyrosine-protein phosphatase non-receptor type 4 OS=Mus musculus GN=Ptpn4 PE=1 SV=2 PF00595//PF00782//PF13180//PF00102 PDZ domain (Also known as DHR or GLGF)//Dual specificity phosphatase, catalytic domain//PDZ domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding -- -- KOG0792 Protein tyrosine phosphatase PTPMEG, contains FERM domain Cluster-8309.34459 BF_2 1680.19 74.08 1236 642926253 XP_008194845.1 1301 1.1e-140 PREDICTED: prohibitin-2 isoform X2 [Tribolium castaneum] 195487314 XM_002091822.1 126 4.98586e-57 Drosophila yakuba GE12002 (Dyak\GE12002), partial mRNA K17081 PHB2 prohibitin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17081 Q99623 1045 2.2e-112 Prohibitin-2 OS=Homo sapiens GN=PHB2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3090 Prohibitin-like protein Cluster-8309.34461 BF_2 6522.37 184.75 1764 478256938 ENN77107.1 746 3.6e-76 hypothetical protein YQE_06442, partial [Dendroctonus ponderosae] 642915784 XM_963085.2 242 2.35476e-121 PREDICTED: Tribolium castaneum cofilin/actin-depolymerizing factor homolog (LOC656560), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 678 1.1e-69 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF07361//PF00241 Cytochrome b562//Cofilin/tropomyosin-type actin-binding protein GO:0022900//GO:0006118 electron transport chain//obsolete electron transport GO:0003779//GO:0005506//GO:0020037//GO:0009055 actin binding//iron ion binding//heme binding//electron carrier activity GO:0042597//GO:0005622 periplasmic space//intracellular KOG1735 Actin depolymerizing factor Cluster-8309.34462 BF_2 6.95 0.37 1078 332373426 AEE61854.1 476 4.5e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14012 SHP1, UBX1, NSFL1C UBX domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14012 Q5RBG3 323 1.0e-28 NSFL1 cofactor p47 OS=Pongo abelii GN=NSFL1C PE=2 SV=1 PF02093//PF00789 Gag P30 core shell protein//UBX domain GO:0019068 virion assembly GO:0005515 protein binding -- -- KOG2086 Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion Cluster-8309.34463 BF_2 105.65 2.46 2084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0000160//GO:0006935//GO:0016310 phosphorelay signal transduction system//chemotaxis//phosphorylation GO:0000155//GO:0004673 phosphorelay sensor kinase activity//protein histidine kinase activity GO:0005737//GO:0009365 cytoplasm//protein histidine kinase complex -- -- Cluster-8309.34464 BF_2 265.94 6.10 2111 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0006935//GO:0000160//GO:0016310 chemotaxis//phosphorelay signal transduction system//phosphorylation GO:0004673//GO:0000155 protein histidine kinase activity//phosphorelay sensor kinase activity GO:0009365//GO:0005737 protein histidine kinase complex//cytoplasm -- -- Cluster-8309.34467 BF_2 31.62 0.64 2351 642933218 XP_008197312.1 1186 4.6e-127 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61369 762 2.7e-79 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.3447 BF_2 4.00 0.76 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14489 QueF-like protein GO:0008616 queuosine biosynthetic process GO:0033739 preQ1 synthase activity -- -- -- -- Cluster-8309.34470 BF_2 2358.08 22.48 4676 189235452 XP_971512.2 641 1.4e-63 PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum]>gi|642916717|ref|XP_008192324.1| PREDICTED: coiled-coil domain-containing protein 102A isoform X1 [Tribolium castaneum] -- -- -- -- -- K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q96A19 379 1.4e-34 Coiled-coil domain-containing protein 102A OS=Homo sapiens GN=CCDC102A PE=1 SV=2 PF04136//PF00015//PF07464//PF10473//PF02050//PF07544//PF17082//PF04048//PF04111//PF01576//PF09728//PF07926//PF03938//PF11403//PF02601//PF03233//PF00038//PF07058//PF04632//PF08287//PF07851//PF01920//PF13851//PF10392//PF08395//PF06160//PF05557//PF08397//PF11365//PF00769//PF11802//PF03836//PF04799//PF07989//PF05837//PF08702//PF04513//PF06008//PF06009//PF04977//PF16331//PF06810//PF10174//PF04508 Sec34-like family//Methyl-accepting chemotaxis protein (MCP) signalling domain//Apolipophorin-III precursor (apoLp-III)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Flagellar FliJ protein//RNA polymerase II transcription mediator complex subunit 9//Spindle Pole Component 29//Sec8 exocyst complex component specific domain//Autophagy protein Apg6//Myosin tail//Myosin-like coiled-coil protein//TPR/MLP1/MLP2-like protein//Outer membrane protein (OmpH-like)//Yeast metallothionein//Exonuclease VII, large subunit//Aphid transmission protein//Intermediate filament protein//Microtubule-associated protein 70//Fusaric acid resistance protein family//Spc19//TMPIT-like protein//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Golgi transport complex subunit 5//7tm Chemosensory receptor//Septation ring formation regulator, EzrA//Mitotic checkpoint protein//IRSp53/MIM homology domain//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Centromere-associated protein K//RasGAP C-terminus//fzo-like conserved region//Centrosomin N-terminal motif 1//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Laminin Domain I//Laminin Domain II//Septum formation initiator//TolA binding protein trimerisation//Phage minor structural protein GP20//RIM-binding protein of the cytomatrix active zone//Viral A-type inclusion protein repeat GO:0030155//GO:0007155//GO:0007009//GO:0006308//GO:0006869//GO:0010273//GO:0030334//GO:0051258//GO:0071585//GO:0008053//GO:0006935//GO:0071973//GO:0006904//GO:0030474//GO:0000921//GO:0006606//GO:0045995//GO:0050909//GO:0007094//GO:0006457//GO:0007049//GO:0015031//GO:0007165//GO:0006914//GO:0006886//GO:0007010//GO:0070206//GO:0006810//GO:0030168//GO:0007264//GO:0016032//GO:0006891//GO:0048870//GO:0019089//GO:0008608//GO:0006357//GO:0010506//GO:0051382 regulation of cell adhesion//cell adhesion//plasma membrane organization//DNA catabolic process//lipid transport//detoxification of copper ion//regulation of cell migration//protein polymerization//detoxification of cadmium ion//mitochondrial fusion//chemotaxis//bacterial-type flagellum-dependent cell motility//vesicle docking involved in exocytosis//spindle pole body duplication//septin ring assembly//protein import into nucleus//regulation of embryonic development//sensory perception of taste//mitotic spindle assembly checkpoint//protein folding//cell cycle//protein transport//signal transduction//autophagy//intracellular protein transport//cytoskeleton organization//protein trimerization//transport//platelet activation//small GTPase mediated signal transduction//viral process//intra-Golgi vesicle-mediated transport//cell motility//transmission of virus//attachment of spindle microtubules to kinetochore//regulation of transcription from RNA polymerase II promoter//regulation of autophagy//kinetochore assembly GO:0004871//GO:0005507//GO:0008855//GO:0005096//GO:0005198//GO:0008092//GO:0008289//GO:0005200//GO:0008134//GO:0042803//GO:0008017//GO:0030674//GO:0003774//GO:0001104//GO:0019905//GO:0051082//GO:0005102//GO:0046870//GO:0003924//GO:0045502 signal transducer activity//copper ion binding//exodeoxyribonuclease VII activity//GTPase activator activity//structural molecule activity//cytoskeletal protein binding//lipid binding//structural constituent of cytoskeleton//transcription factor binding//protein homodimerization activity//microtubule binding//protein binding, bridging//motor activity//RNA polymerase II transcription cofactor activity//syntaxin binding//unfolded protein binding//receptor binding//cadmium ion binding//GTPase activity//dynein binding GO:0005576//GO:0000145//GO:0019031//GO:0005823//GO:0042729//GO:0005737//GO:0005876//GO:0005815//GO:0016021//GO:0016459//GO:0005940//GO:0016592//GO:0030286//GO:0009318//GO:0048786//GO:0005577//GO:0019898//GO:0005882//GO:0005741//GO:0017119//GO:0016020//GO:0005634//GO:0005856//GO:0005886//GO:0005801//GO:0031514//GO:0000776//GO:0005667//GO:0009288//GO:0005615//GO:0016272//GO:0019028//GO:0045298 extracellular region//exocyst//viral envelope//central plaque of spindle pole body//DASH complex//cytoplasm//spindle microtubule//microtubule organizing center//integral component of membrane//myosin complex//septin ring//mediator complex//dynein complex//exodeoxyribonuclease VII complex//presynaptic active zone//fibrinogen complex//extrinsic component of membrane//intermediate filament//mitochondrial outer membrane//Golgi transport complex//membrane//nucleus//cytoskeleton//plasma membrane//cis-Golgi network//motile cilium//kinetochore//transcription factor complex//bacterial-type flagellum//extracellular space//prefoldin complex//viral capsid//tubulin complex -- -- Cluster-8309.34471 BF_2 130.87 0.87 6572 642936804 XP_008199623.1 5937 0.0e+00 PREDICTED: protein sickie isoform X1 [Tribolium castaneum] -- -- -- -- -- K19483 NAV2 neuron navigator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19483 Q9VIQ9 1202 7.3e-130 Protein sickie OS=Drosophila melanogaster GN=sick PE=3 SV=3 PF10473//PF06160//PF07926//PF08702//PF00910//PF00307//PF16326//PF04111//PF07728//PF01695//PF01832//PF16716//PF00004//PF13851 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//TPR/MLP1/MLP2-like protein//Fibrinogen alpha/beta chain family//RNA helicase//Calponin homology (CH) domain//ABC transporter C-terminal domain//Autophagy protein Apg6//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase//Bone marrow stromal antigen 2//ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding GO:0007165//GO:0006914//GO:0051258//GO:0006558//GO:0042207//GO:0006560//GO:0051607//GO:0006525//GO:0006568//GO:0006606//GO:0018874//GO:0000921//GO:0048870//GO:0030168 signal transduction//autophagy//protein polymerization//L-phenylalanine metabolic process//styrene catabolic process//proline metabolic process//defense response to virus//arginine metabolic process//tryptophan metabolic process//protein import into nucleus//benzoate metabolic process//septin ring assembly//cell motility//platelet activation GO:0003677//GO:0004040//GO:0003723//GO:0005515//GO:0042803//GO:0003724//GO:0005524//GO:0045502//GO:0008134//GO:0005102//GO:0016887//GO:0030674 DNA binding//amidase activity//RNA binding//protein binding//protein homodimerization activity//RNA helicase activity//ATP binding//dynein binding//transcription factor binding//receptor binding//ATPase activity//protein binding, bridging GO:0031514//GO:0016021//GO:0005940//GO:0005577//GO:0030286//GO:0005667 motile cilium//integral component of membrane//septin ring//fibrinogen complex//dynein complex//transcription factor complex -- -- Cluster-8309.34472 BF_2 271.74 40.18 570 91083531 XP_973193.1 501 3.0e-48 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q28960 221 3.6e-17 Carbonyl reductase [NADPH] 1 OS=Sus scrofa GN=CBR1 PE=1 SV=3 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.34474 BF_2 505.78 19.13 1393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34475 BF_2 45.01 1.10 2000 546684091 ERL93810.1 1173 1.2e-125 hypothetical protein D910_11096 [Dendroctonus ponderosae] -- -- -- -- -- K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 566 1.2e-56 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.34476 BF_2 692.21 7.99 3910 91084587 XP_974100.1 2514 7.8e-281 PREDICTED: zinc finger FYVE domain-containing protein 9 [Tribolium castaneum]>gi|270008651|gb|EFA05099.1| hypothetical protein TcasGA2_TC015198 [Tribolium castaneum] -- -- -- -- -- K04679 MADHIP, SARA MAD, mothers against decapentaplegic interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K04679 O95405 1383 4.5e-151 Zinc finger FYVE domain-containing protein 9 OS=Homo sapiens GN=ZFYVE9 PE=1 SV=2 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1841 Smad anchor for receptor activation Cluster-8309.34477 BF_2 243.23 1.55 6837 332376178 AEE63229.1 915 3.5e-95 unknown [Dendroctonus ponderosae] 642924593 XM_008196134.1 241 3.32878e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.3e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 PF06810 Phage minor structural protein GP20 -- -- GO:0005198 structural molecule activity -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.34478 BF_2 30.65 0.54 2662 270005744 EFA02192.1 2842 0.0e+00 hypothetical protein TcasGA2_TC007848 [Tribolium castaneum] 703110936 XM_010101429.1 38 9.04873e-08 Morus notabilis putative phosphoribosylformylglycinamidine synthase partial mRNA K01952 purL, PFAS phosphoribosylformylglycinamidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01952 P35421 1933 5.1e-215 Phosphoribosylformylglycinamidine synthase OS=Drosophila melanogaster GN=ade2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1907 Phosphoribosylformylglycinamidine synthase Cluster-8309.34479 BF_2 321.75 8.22 1924 642936774 XP_008198575.1 406 1.0e-36 PREDICTED: uncharacterized protein LOC661827 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34480 BF_2 2477.53 47.01 2492 731286412 XP_010611509.1 690 1.6e-69 PREDICTED: LOW QUALITY PROTEIN: histone H3.3 [Fukomys damarensis] 805824145 XM_003708049.2 153 9.98584e-72 PREDICTED: Megachile rotundata histone H3.3 (LOC100883938), mRNA K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P84246 676 2.7e-69 Histone H3.3 OS=Oryctolagus cuniculus GN=H3F3A PE=2 SV=2 PF15715//PF00125 PCNA-associated factor//Core histone H2A/H2B/H3/H4 GO:0051726//GO:0006974 regulation of cell cycle//cellular response to DNA damage stimulus GO:0003677 DNA binding -- -- KOG1745 Histones H3 and H4 Cluster-8309.34481 BF_2 127.00 1.80 3233 642933939 XP_008197575.1 2048 7.0e-227 PREDICTED: ADP-ribosylation factor-binding protein GGA3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12404 GGA ADP-ribosylation factor-binding protein GGA http://www.genome.jp/dbget-bin/www_bget?ko:K12404 Q8R0H9 662 1.5e-67 ADP-ribosylation factor-binding protein GGA1 OS=Mus musculus GN=Gga1 PE=1 SV=1 PF03127//PF00790//PF15009//PF02883 GAT domain//VHS domain//Transmembrane protein 173//Adaptin C-terminal domain GO:0016192//GO:0032481//GO:0006886//GO:0002218 vesicle-mediated transport//positive regulation of type I interferon production//intracellular protein transport//activation of innate immune response -- -- GO:0005622//GO:0030131 intracellular//clathrin adaptor complex KOG1086 Cytosolic sorting protein/ADP-ribosylation factor effector GGA Cluster-8309.34482 BF_2 415.24 4.83 3886 270015601 EFA12049.1 1924 2.0e-212 hypothetical protein TcasGA2_TC001466 [Tribolium castaneum] -- -- -- -- -- K17277 EPS8 epidermal growth factor receptor kinase substrate 8 http://www.genome.jp/dbget-bin/www_bget?ko:K17277 Q8TE68 506 2.2e-49 Epidermal growth factor receptor kinase substrate 8-like protein 1 OS=Homo sapiens GN=EPS8L1 PE=1 SV=3 PF08416//PF09286//PF14604//PF00018 Phosphotyrosine-binding domain//Pro-kumamolisin, activation domain//Variant SH3 domain//SH3 domain -- -- GO:0005515//GO:0008236 protein binding//serine-type peptidase activity -- -- KOG3557 Epidermal growth factor receptor kinase substrate Cluster-8309.34484 BF_2 2611.82 52.86 2354 642931172 XP_008196469.1 1319 1.7e-142 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34485 BF_2 1631.00 104.83 938 91086729 XP_971227.1 469 2.5e-44 PREDICTED: uncharacterized protein LOC659867 [Tribolium castaneum]>gi|270009730|gb|EFA06178.1| hypothetical protein TcasGA2_TC009025 [Tribolium castaneum] -- -- -- -- -- K03956 NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K03956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34486 BF_2 17.42 0.43 2000 642914160 XP_008201571.1 451 6.6e-42 PREDICTED: muscle-specific protein 20 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14318 356 2.8e-32 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.34487 BF_2 407.91 7.21 2654 642928356 XP_008195548.1 1493 1.3e-162 PREDICTED: abhydrolase domain-containing protein 4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K13699 ABHD5, CGI-58 abhydrolase domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13699 Q5RBI4 855 5.1e-90 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Pongo abelii GN=ABHD5 PE=2 SV=1 PF01055//PF02230//PF00975//PF01764//PF16929//PF07819//PF07859//PF03403 Glycosyl hydrolases family 31//Phospholipase/Carboxylesterase//Thioesterase domain//Lipase (class 3)//Accessory Sec system GspB-transporter//PGAP1-like protein//alpha/beta hydrolase fold//Platelet-activating factor acetylhydrolase, isoform II GO:0016042//GO:0046486//GO:0009058//GO:0005975//GO:0015031//GO:0008152//GO:0006505//GO:0006629//GO:0006886 lipid catabolic process//glycerolipid metabolic process//biosynthetic process//carbohydrate metabolic process//protein transport//metabolic process//GPI anchor metabolic process//lipid metabolic process//intracellular protein transport GO:0016787//GO:0003847//GO:0004553//GO:0016788 hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.34488 BF_2 819.00 7.84 4657 -- -- -- -- -- 642927804 XM_966071.3 102 4.2104e-43 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (LOC659798), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34489 BF_2 200.95 1.42 6220 642935794 XP_008198177.1 369 6.6e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00864//PF00335 ATP P2X receptor//Tetraspanin family GO:0007165//GO:0006812//GO:0033198//GO:0098655 signal transduction//cation transport//response to ATP//cation transmembrane transport GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane -- -- Cluster-8309.34491 BF_2 434.00 10.02 2099 189240498 XP_001810958.1 950 9.5e-100 PREDICTED: uncharacterized protein LOC657358 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34493 BF_2 6059.00 70.98 3858 91082073 XP_966419.1 3806 0.0e+00 PREDICTED: 26S proteasome non-ATPase regulatory subunit 1 [Tribolium castaneum] 195341140 XM_002037134.1 390 0 Drosophila sechellia GM12772 (Dsec\GM12772), mRNA K03032 PSMD1, RPN2 26S proteasome regulatory subunit N2 http://www.genome.jp/dbget-bin/www_bget?ko:K03032 Q9V3P6 3237 0.0e+00 26S proteasome non-ATPase regulatory subunit 1 OS=Drosophila melanogaster GN=Rpn2 PE=1 SV=1 PF02985//PF05132 HEAT repeat//RNA polymerase III RPC4 GO:0006206//GO:0006351//GO:0006383//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005666//GO:0005730 DNA-directed RNA polymerase III complex//nucleolus KOG2062 26S proteasome regulatory complex, subunit RPN2/PSMD1 Cluster-8309.34495 BF_2 8.51 0.38 1223 646718601 KDR21013.1 277 6.0e-22 hypothetical protein L798_04525 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6NZZ4 210 1.5e-15 Transmembrane protein 107 OS=Danio rerio GN=tmem107 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34496 BF_2 49.00 29.24 353 597867992 EYC17382.1 282 4.6e-23 hypothetical protein Y032_0031g2442 [Ancylostoma ceylanicum] 54287863 AY626605.1 225 1.22977e-112 Prodinychus sp. AL7170 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 182 7.4e-13 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34497 BF_2 187.00 31.18 538 678336953 CDW75723.1 354 3.1e-31 UNKNOWN [Stylonychia lemnae] 700674210 LC007067.1 243 1.90907e-122 Meristoderes macracanthus gene for 28S rRNA, partial sequence, isolate: HY-Me04 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34500 BF_2 219.00 6.43 1713 189233602 XP_001810921.1 1256 2.5e-135 PREDICTED: F-box only protein 28 [Tribolium castaneum] -- -- -- -- -- K10306 FBXO28 F-box protein 28 http://www.genome.jp/dbget-bin/www_bget?ko:K10306 Q2NL16 558 9.1e-56 F-box only protein 28 OS=Bos taurus GN=FBXO28 PE=2 SV=1 PF07851//PF00646//PF11744//PF12937//PF04108//PF10778//PF17060 TMPIT-like protein//F-box domain//Aluminium activated malate transporter//F-box-like//Autophagy protein Apg17//Halocarboxylic acid dehydrogenase DehI//Monopolar spindle protein 2 GO:0030474//GO:0006914//GO:0015743//GO:0071988 spindle pole body duplication//autophagy//malate transport//protein localization to spindle pole body GO:0005515//GO:0019120 protein binding//hydrolase activity, acting on acid halide bonds, in C-halide compounds GO:0016021 integral component of membrane -- -- Cluster-8309.34501 BF_2 29.75 0.54 2587 91086413 XP_967009.1 1442 1.0e-156 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270010301|gb|EFA06749.1| hypothetical protein TcasGA2_TC009683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MYA4 555 3.0e-55 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.34502 BF_2 2066.11 22.32 4159 642918967 XP_008191677.1 4787 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918969|ref|XP_008191678.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918971|ref|XP_008191679.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918973|ref|XP_008191680.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum]>gi|642918975|ref|XP_008191681.1| PREDICTED: probable phospholipid-transporting ATPase IA isoform X1 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.29498e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3178 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122//PF05109 E1-E2 ATPase//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.34503 BF_2 49.77 5.29 681 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34504 BF_2 554.04 12.45 2149 91080419 XP_968050.1 1723 2.2e-189 PREDICTED: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase [Tribolium castaneum]>gi|270005750|gb|EFA02198.1| hypothetical protein TcasGA2_TC007854 [Tribolium castaneum] -- -- -- -- -- K01001 ALG7 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01001 Q9H3H5 1192 3.5e-129 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase OS=Homo sapiens GN=DPAGT1 PE=1 SV=2 PF00953 Glycosyl transferase family 4 GO:0009252//GO:0006629 peptidoglycan biosynthetic process//lipid metabolic process GO:0008963 phospho-N-acetylmuramoyl-pentapeptide-transferase activity GO:0016021 integral component of membrane KOG2788 Glycosyltransferase Cluster-8309.34505 BF_2 368.00 18.71 1110 91080581 XP_973561.1 1144 1.6e-122 PREDICTED: splicing factor 3A subunit 2 [Tribolium castaneum]>gi|270005516|gb|EFA01964.1| hypothetical protein TcasGA2_TC007585 [Tribolium castaneum] 648215768 NM_001293501.1 234 4.10465e-117 Acyrthosiphon pisum splicing factor 3A subunit 2 (LOC100159176), mRNA >gnl|BL_ORD_ID|6893865 Acyrthosiphon pisum ACYPI000572 mRNA, clone: 636K7, complete cds, full-insert cDNA sequence based on the ESTs (5'-EST:FF319503, 3'-EST:FF320245) K12826 SF3A2, SAP62 splicing factor 3A subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12826 Q6AXT8 982 4.0e-105 Splicing factor 3A subunit 2 OS=Rattus norvegicus GN=Sf3a2 PE=2 SV=1 PF09732 Cactus-binding C-terminus of cactin protein -- -- GO:0005515//GO:0046872//GO:0008270//GO:0003676 protein binding//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0227 Splicing factor 3a, subunit 2 Cluster-8309.34506 BF_2 51.66 2.64 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34507 BF_2 2296.84 18.99 5346 189239912 XP_971042.2 1378 5.7e-149 PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|642931218|ref|XP_008196488.1| PREDICTED: uncharacterized protein LOC659663 [Tribolium castaneum]>gi|270012116|gb|EFA08564.1| hypothetical protein TcasGA2_TC006219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GLM5 222 2.6e-16 Desumoylating isopeptidase 1 OS=Xenopus laevis GN=desi1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.34510 BF_2 15373.36 456.15 1697 662186144 XP_008480683.1 1100 3.1e-117 PREDICTED: tubulin beta-1 chain [Diaphorina citri] 164683615 EU373305.1 709 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q24560 1099 1.7e-118 Tubulin beta-1 chain OS=Drosophila melanogaster GN=betaTub56D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1375 Beta tubulin Cluster-8309.34514 BF_2 382.87 10.43 1823 189239156 XP_971579.2 1213 2.6e-130 PREDICTED: 39S ribosomal protein L37, mitochondrial [Tribolium castaneum]>gi|270010833|gb|EFA07281.1| hypothetical protein TcasGA2_TC014515 [Tribolium castaneum] -- -- -- -- -- K17418 MRPL37 large subunit ribosomal protein L37 http://www.genome.jp/dbget-bin/www_bget?ko:K17418 Q9BZE1 239 9.4e-19 39S ribosomal protein L37, mitochondrial OS=Homo sapiens GN=MRPL37 PE=1 SV=2 PF07147 Mitochondrial 28S ribosomal protein S30 (PDCD9) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005739//GO:0043229//GO:0044444//GO:0005840 mitochondrion//intracellular organelle//cytoplasmic part//ribosome -- -- Cluster-8309.34515 BF_2 22.69 1.06 1183 189239156 XP_971579.2 1064 3.2e-113 PREDICTED: 39S ribosomal protein L37, mitochondrial [Tribolium castaneum]>gi|270010833|gb|EFA07281.1| hypothetical protein TcasGA2_TC014515 [Tribolium castaneum] -- -- -- -- -- K17418 MRPL37 large subunit ribosomal protein L37 http://www.genome.jp/dbget-bin/www_bget?ko:K17418 Q9BZE1 220 9.8e-17 39S ribosomal protein L37, mitochondrial OS=Homo sapiens GN=MRPL37 PE=1 SV=2 -- -- -- -- -- -- GO:0044444//GO:0043229 cytoplasmic part//intracellular organelle -- -- Cluster-8309.34516 BF_2 354.47 3.64 4361 642936108 XP_974757.2 1282 6.3e-138 PREDICTED: fumarylacetoacetate hydrolase domain-containing protein 2A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96GK7 823 4.3e-86 Fumarylacetoacetate hydrolase domain-containing protein 2A OS=Homo sapiens GN=FAHD2A PE=1 SV=1 PF01632//PF01557 Ribosomal protein L35//Fumarylacetoacetate (FAA) hydrolase family GO:0042254//GO:0006412//GO:0008152 ribosome biogenesis//translation//metabolic process GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG1535 Predicted fumarylacetoacetate hydralase Cluster-8309.34517 BF_2 776.82 26.04 1535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06046//PF08140 Exocyst complex component Sec6//Crustacean cuticle protein repeat GO:0006887 exocytosis GO:0042302 structural constituent of cuticle GO:0000145 exocyst -- -- Cluster-8309.34518 BF_2 383.45 35.19 743 91091878 XP_969758.1 559 7.3e-55 PREDICTED: von Willebrand factor D and EGF domain-containing protein [Tribolium castaneum]>gi|270001301|gb|EEZ97748.1| nimrod B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2E2 169 5.0e-11 von Willebrand factor D and EGF domain-containing protein OS=Homo sapiens GN=VWDE PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34519 BF_2 1389.32 42.24 1663 332376717 AEE63498.1 1208 9.1e-130 unknown [Dendroctonus ponderosae]>gi|478259809|gb|ENN79637.1| hypothetical protein YQE_03926, partial [Dendroctonus ponderosae]>gi|546676567|gb|ERL87551.1| hypothetical protein D910_04942 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5BLY5 636 7.9e-65 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.34520 BF_2 108.08 0.84 5646 827549501 XP_012546855.1 643 1.0e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.6e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.34521 BF_2 55.82 0.84 3061 91081871 XP_968443.1 1594 2.9e-174 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q99LB7 1137 1.2e-122 Sarcosine dehydrogenase, mitochondrial OS=Mus musculus GN=Sardh PE=1 SV=1 PF11501//PF07992//PF01494//PF12831//PF01266//PF13241//PF02558//PF01134 Non structural protein Nsp1//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A GO:0006508//GO:0044710//GO:0019354//GO:0008033//GO:0006779//GO:0055114//GO:0015940 proteolysis//single-organism metabolic process//siroheme biosynthetic process//tRNA processing//porphyrin-containing compound biosynthetic process//oxidation-reduction process//pantothenate biosynthetic process GO:0016817//GO:0004197//GO:0050660//GO:0008677//GO:0016491//GO:0043115//GO:0008242//GO:0016788//GO:0003824//GO:0016740//GO:0071949 hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity//precorrin-2 dehydrogenase activity//omega peptidase activity//hydrolase activity, acting on ester bonds//catalytic activity//transferase activity//FAD binding -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.34522 BF_2 475.66 7.19 3054 91081871 XP_968443.1 2434 1.1e-271 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q64380 1609 2.2e-177 Sarcosine dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Sardh PE=1 SV=2 PF01494//PF07992//PF11501//PF12831//PF01266//PF13241//PF02558//PF01134 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Non structural protein Nsp1//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A GO:0006508//GO:0019354//GO:0044710//GO:0055114//GO:0008033//GO:0006779//GO:0015940 proteolysis//siroheme biosynthetic process//single-organism metabolic process//oxidation-reduction process//tRNA processing//porphyrin-containing compound biosynthetic process//pantothenate biosynthetic process GO:0050660//GO:0008677//GO:0004197//GO:0016817//GO:0016788//GO:0003824//GO:0008242//GO:0043115//GO:0016491//GO:0071949//GO:0016740 flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//hydrolase activity, acting on ester bonds//catalytic activity//omega peptidase activity//precorrin-2 dehydrogenase activity//oxidoreductase activity//FAD binding//transferase activity -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.34523 BF_2 11.71 0.97 793 91094797 XP_966355.1 1162 9.3e-125 PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|642922944|ref|XP_008200463.1| PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|642922946|ref|XP_008200464.1| PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|270006580|gb|EFA03028.1| hypothetical protein TcasGA2_TC010452 [Tribolium castaneum] 157383089 EF654567.1 351 0 Anthela adriana voucher DNA/AZ151 elongation factor-1 alpha (EF1a) gene, partial cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P29520 1139 1.8e-123 Elongation factor 1-alpha OS=Bombyx mori PE=2 SV=1 PF04670//PF01926 Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase GO:0006448//GO:0006414//GO:0006184 regulation of translational elongation//translational elongation//obsolete GTP catabolic process GO:0003924//GO:0005525//GO:0003746 GTPase activity//GTP binding//translation elongation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.34525 BF_2 67.16 1.88 1781 642922362 XP_008193125.1 1615 6.2e-177 PREDICTED: sodium-coupled monocarboxylate transporter 1-like isoform X2 [Tribolium castaneum]>gi|642922364|ref|XP_008193126.1| PREDICTED: sodium-coupled monocarboxylate transporter 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 691 3.6e-71 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.34526 BF_2 914.73 13.64 3092 642931035 XP_008196187.1 394 4.1e-35 PREDICTED: uncharacterized protein LOC103313793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09297//PF05497 NADH pyrophosphatase zinc ribbon domain//Destabilase GO:0005975 carbohydrate metabolic process GO:0016787//GO:0003796//GO:0046872 hydrolase activity//lysozyme activity//metal ion binding -- -- -- -- Cluster-8309.34527 BF_2 160.73 1.32 5387 189239886 XP_969203.2 1791 7.3e-197 PREDICTED: protein tweety [Tribolium castaneum] 642931168 XM_964110.3 243 2.0256e-121 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1074 4.2e-115 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.34528 BF_2 68.50 5.70 790 755966405 XP_011305489.1 219 2.1e-15 PREDICTED: 60S acidic ribosomal protein P1 [Fopius arisanus] 642922948 XM_967363.3 83 2.51434e-33 PREDICTED: Tribolium castaneum 60S acidic ribosomal protein P1 (LOC661185), mRNA K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P08570 208 1.6e-15 60S acidic ribosomal protein P1 OS=Drosophila melanogaster GN=RpLP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.34530 BF_2 323.91 4.41 3361 642937688 XP_008198902.1 1087 2.0e-115 PREDICTED: E3 ubiquitin-protein ligase RNF126 isoform X1 [Tribolium castaneum] 170048596 XM_001870670.1 46 4.08891e-12 Culex quinquefasciatus RING finger protein 126-B, mRNA K11982 RNF115_126 E3 ubiquitin-protein ligase RNF115/126 http://www.genome.jp/dbget-bin/www_bget?ko:K11982 Q91YL2 436 2.5e-41 E3 ubiquitin-protein ligase RNF126 OS=Mus musculus GN=Rnf126 PE=1 SV=1 PF13639//PF01155//PF00097//PF12678//PF17123//PF12861//PF14634 Ring finger domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain GO:0016567//GO:0006464 protein ubiquitination//cellular protein modification process GO:0046872//GO:0008270//GO:0016151//GO:0004842//GO:0005515 metal ion binding//zinc ion binding//nickel cation binding//ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.34532 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34533 BF_2 280.00 4.51 2884 478260599 ENN80302.1 1505 5.7e-164 hypothetical protein YQE_03295, partial [Dendroctonus ponderosae]>gi|546685269|gb|ERL94796.1| hypothetical protein D910_12070 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5TFE4 526 7.8e-52 5'-nucleotidase domain-containing protein 1 OS=Homo sapiens GN=NT5DC1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2470 Similar to IMP-GMP specific 5'-nucleotidase Cluster-8309.34535 BF_2 3.00 41.79 225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34536 BF_2 601.00 11.18 2536 91076080 XP_967713.1 925 9.1e-97 PREDICTED: ADP-ribosylation factor 6 [Tribolium castaneum]>gi|270014695|gb|EFA11143.1| hypothetical protein TcasGA2_TC004744 [Tribolium castaneum] 462311205 APGK01047050.1 264 2.00694e-133 Dendroctonus ponderosae Seq01047060, whole genome shotgun sequence K07941 ARF6 ADP-ribosylation factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K07941 P26990 906 5.9e-96 ADP-ribosylation factor 6 OS=Gallus gallus GN=ARF6 PE=2 SV=3 PF01926//PF08477//PF00025//PF01591//PF04881//PF04670//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//6-phosphofructo-2-kinase//Adenovirus GP19K//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit GO:0007165//GO:0050690//GO:0007186//GO:0006000//GO:0006013//GO:0007264 signal transduction//regulation of defense response to virus by virus//G-protein coupled receptor signaling pathway//fructose metabolic process//mannose metabolic process//small GTPase mediated signal transduction GO:0031683//GO:0005537//GO:0005524//GO:0003924//GO:0003873//GO:0004871//GO:0019001//GO:0005525 G-protein beta/gamma-subunit complex binding//mannose binding//ATP binding//GTPase activity//6-phosphofructo-2-kinase activity//signal transducer activity//guanyl nucleotide binding//GTP binding GO:0005622 intracellular KOG0071 GTP-binding ADP-ribosylation factor Arf6 (dArf3) Cluster-8309.34541 BF_2 108.75 1.98 2579 549438519 AGX25148.1 2765 4.0e-310 beta-glucuronidase-like protein [Leptinotarsa decemlineata] 195400569 XM_002058853.1 36 1.13354e-06 Drosophila virilis GJ19669 (Dvir\GJ19669), mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P08236 1387 1.0e-151 Beta-glucuronidase OS=Homo sapiens GN=GUSB PE=1 SV=2 PF02836//PF00703//PF02837 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.34542 BF_2 40.25 1.43 1464 478251391 ENN71857.1 403 1.8e-36 hypothetical protein YQE_11473, partial [Dendroctonus ponderosae] -- -- -- -- -- K10839 RAD23, HR23 UV excision repair protein RAD23 http://www.genome.jp/dbget-bin/www_bget?ko:K10839 P54726 280 1.3e-23 UV excision repair protein RAD23 homolog A OS=Mus musculus GN=Rad23a PE=1 SV=2 PF00995//PF09280 Sec1 family//XPC-binding domain GO:0006904//GO:0006289//GO:0043161//GO:0006281//GO:0016192 vesicle docking involved in exocytosis//nucleotide-excision repair//proteasome-mediated ubiquitin-dependent protein catabolic process//DNA repair//vesicle-mediated transport GO:0003684 damaged DNA binding -- -- KOG0011 Nucleotide excision repair factor NEF2, RAD23 component Cluster-8309.34544 BF_2 10.00 0.35 1479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12567 Leukocyte receptor CD45 GO:0006470//GO:0006570//GO:0050852 protein dephosphorylation//tyrosine metabolic process//T cell receptor signaling pathway GO:0004725 protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.34545 BF_2 53.27 0.43 5461 478251732 ENN72185.1 487 1.2e-45 hypothetical protein YQE_11170, partial [Dendroctonus ponderosae]>gi|546682227|gb|ERL92188.1| hypothetical protein D910_09508 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09564 147 1.3e-07 Protein phosphatase PHLPP-like protein OS=Caenorhabditis elegans GN=F43C1.1 PE=3 SV=2 PF02052//PF13855//PF00560 Gallidermin//Leucine rich repeat//Leucine Rich Repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0005576 extracellular region KOG0619 FOG: Leucine rich repeat Cluster-8309.34546 BF_2 39.00 5.71 573 270013391 EFA09839.1 816 8.9e-85 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 145 2.4e-08 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.34549 BF_2 30.27 0.44 3180 642933795 XP_008197323.1 3601 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2199 8.7e-246 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF00437//PF01637//PF00664//PF13304//PF01926//PF00005//PF03193 Type II/IV secretion system protein//Archaeal ATPase//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0006810 transmembrane transport//transport GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.34551 BF_2 7109.51 1265.85 522 91085777 XP_974360.1 705 6.0e-72 PREDICTED: 60S ribosomal protein L23 [Tribolium castaneum]>gi|270010126|gb|EFA06574.1| hypothetical protein TcasGA2_TC009485 [Tribolium castaneum] 110671519 DQ673438.1 168 9.10085e-81 Diaphorina citri putative ribosomal protein L17/23 mRNA, complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 Q9GNE2 669 3.7e-69 60S ribosomal protein L23 OS=Aedes aegypti GN=RpL23-A PE=2 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.34552 BF_2 271.57 1.69 6992 642918310 XP_008191453.1 3659 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 3.8e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00010//PF01017//PF00168//PF01530 Helix-loop-helix DNA-binding domain//STAT protein, all-alpha domain//C2 domain//Zinc finger, C2HC type GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0046983//GO:0003700//GO:0004871//GO:0008270 protein binding//protein dimerization activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.34554 BF_2 241.89 1.88 5674 332376995 AEE63637.1 1603 4.9e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 264 4.52281e-133 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 4.7e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00769//PF00487 Ezrin/radixin/moesin family//Fatty acid desaturase GO:0006629 lipid metabolic process GO:0008092 cytoskeletal protein binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2987 Fatty acid desaturase Cluster-8309.34555 BF_2 37.41 1.25 1537 91079965 XP_969696.1 445 2.5e-41 PREDICTED: 60S ribosomal protein L14 [Tribolium castaneum]>gi|270004603|gb|EFA01051.1| hypothetical protein TcasGA2_TC003967 [Tribolium castaneum] -- -- -- -- -- K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 Q95ZE8 331 1.7e-29 60S ribosomal protein L14 OS=Drosophila virilis GN=RpL14 PE=3 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3421 60S ribosomal protein L14 Cluster-8309.34556 BF_2 85.00 2.21 1893 642910655 XP_008200044.1 1960 6.5e-217 PREDICTED: uncharacterized protein C12orf4 homolog isoform X1 [Tribolium castaneum]>gi|270014514|gb|EFA10962.1| hypothetical protein TcasGA2_TC004122 [Tribolium castaneum] 571513850 XM_394347.5 51 3.79763e-15 PREDICTED: Apis mellifera uncharacterized protein C12orf4 homolog (LOC410871), mRNA -- -- -- -- Q5RD58 930 7.3e-99 Protein C12orf4 homolog OS=Pongo abelii PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4506 Uncharacterized conserved protein Cluster-8309.34557 BF_2 532.24 6.97 3480 805776063 XP_012137915.1 1666 1.5e-182 PREDICTED: eukaryotic translation initiation factor 2-alpha kinase isoform X1 [Megachile rotundata]>gi|805776066|ref|XP_012137916.1| PREDICTED: eukaryotic translation initiation factor 2-alpha kinase isoform X1 [Megachile rotundata] -- -- -- -- -- K08860 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08860 Q9Z1Z1 685 3.5e-70 Eukaryotic translation initiation factor 2-alpha kinase 3 OS=Rattus norvegicus GN=Eif2ak3 PE=1 SV=1 PF10588//PF07714//PF00069//PF06293 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0055114 protein phosphorylation//oxidation-reduction process GO:0016773//GO:0005524//GO:0016491//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//oxidoreductase activity//protein kinase activity GO:0016020 membrane KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.34558 BF_2 50.85 0.43 5207 642925960 XP_008195671.1 2730 9.3e-306 PREDICTED: neurotrypsin-like [Tribolium castaneum]>gi|270009237|gb|EFA05685.1| serine protease P153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08762 744 7.4e-77 Neurotrypsin OS=Mus musculus GN=Prss12 PE=2 SV=1 PF01380//PF02449//PF15494//PF00089//PF04178//PF00057//PF01607//PF00530 SIS domain//Beta-galactosidase//Scavenger receptor cysteine-rich domain//Trypsin//Got1/Sft2-like family//Low-density lipoprotein receptor domain class A//Chitin binding Peritrophin-A domain//Scavenger receptor cysteine-rich domain GO:0016192//GO:0006030//GO:0007165//GO:0046486//GO:0005975//GO:0006687//GO:0006027//GO:0006012//GO:0006508 vesicle-mediated transport//chitin metabolic process//signal transduction//glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process//proteolysis GO:0004565//GO:0004252//GO:0008233//GO:0030246//GO:0005515//GO:0005044//GO:0008061 beta-galactosidase activity//serine-type endopeptidase activity//peptidase activity//carbohydrate binding//protein binding//scavenger receptor activity//chitin binding GO:0009341//GO:0016020//GO:0005576 beta-galactosidase complex//membrane//extracellular region -- -- Cluster-8309.34559 BF_2 1227.60 21.33 2695 478252633 ENN73038.1 1480 4.2e-161 hypothetical protein YQE_10373, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P48594 545 4.6e-54 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34560 BF_2 1552.28 52.63 1521 642936612 XP_008198506.1 730 2.2e-74 PREDICTED: uncharacterized protein LOC661523 isoform X2 [Tribolium castaneum]>gi|270013067|gb|EFA09515.1| hypothetical protein TcasGA2_TC011617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34562 BF_2 1008.99 23.07 2117 642916373 XP_008190993.1 925 7.6e-97 PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum]>gi|642916375|ref|XP_008190995.1| PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q6P6R0 539 1.8e-53 Protein lifeguard 1 OS=Rattus norvegicus GN=Grina PE=2 SV=1 PF05393 Human adenovirus early E3A glycoprotein -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.34565 BF_2 1713.49 33.77 2410 332376166 AEE63223.1 797 6.0e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q86BN8 610 1.2e-61 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Drosophila melanogaster GN=Plip PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1719 Dual specificity phosphatase Cluster-8309.34566 BF_2 13.11 0.78 988 642929422 XP_008195833.1 274 1.1e-21 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02761 CBL proto-oncogene N-terminus, EF hand-like domain -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.34567 BF_2 74.26 0.54 5996 189240170 XP_975082.2 2046 2.2e-226 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X1 [Tribolium castaneum]>gi|642932079|ref|XP_008196849.1| PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 1037 9.1e-111 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 PF08465//PF13465//PF00096 Thymidine kinase from Herpesvirus C-terminal//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006230//GO:0006206 TMP biosynthetic process//pyrimidine nucleobase metabolic process GO:0046872//GO:0005524//GO:0004797 metal ion binding//ATP binding//thymidine kinase activity -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.34568 BF_2 222.89 6.57 1706 91088707 XP_975095.1 293 1.2e-23 PREDICTED: mitochondrial 2-oxoglutarate/malate carrier protein [Tribolium castaneum]>gi|270012291|gb|EFA08739.1| hypothetical protein TcasGA2_TC006414 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 247 1.0e-19 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 -- -- GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.34569 BF_2 723.42 7.77 4181 270014508 EFA10956.1 1385 6.8e-150 hypothetical protein TcasGA2_TC004116 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 P05049 565 3.4e-56 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089//PF01529//PF12422 Trypsin//DHHC palmitoyltransferase//Condensin II non structural maintenance of chromosomes subunit GO:0006508 proteolysis GO:0008270//GO:0004252 zinc ion binding//serine-type endopeptidase activity GO:0005634 nucleus -- -- Cluster-8309.34570 BF_2 945.19 7.01 5924 270016366 EFA12812.1 392 1.4e-34 hypothetical protein TcasGA2_TC001877 [Tribolium castaneum] 642933104 XM_008199038.1 222 1.05177e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03485 Arginyl tRNA synthetase N terminal domain GO:0006560//GO:0006525//GO:0006420 proline metabolic process//arginine metabolic process//arginyl-tRNA aminoacylation GO:0004814//GO:0000166//GO:0005524 arginine-tRNA ligase activity//nucleotide binding//ATP binding GO:0005737 cytoplasm -- -- Cluster-8309.34572 BF_2 2192.89 21.23 4609 642922013 XP_008192985.1 2785 0.0e+00 PREDICTED: argonaute-2b isoform X1 [Tribolium castaneum] -- -- -- -- -- K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 1392 4.8e-152 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF02926//PF02170//PF02171 THUMP domain//PAZ domain//Piwi domain -- -- GO:0003676//GO:0003723//GO:0005515 nucleic acid binding//RNA binding//protein binding -- -- KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.34573 BF_2 11.36 0.99 765 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34574 BF_2 972.05 4.70 8940 642934775 XP_008197803.1 5864 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 411 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.34575 BF_2 1013.00 12.24 3750 751657251 AJF94884.1 846 1.9e-87 C1 family cathepsin O12 [Tenebrio molitor] -- -- -- -- -- K01374 CTSO cathepsin O http://www.genome.jp/dbget-bin/www_bget?ko:K01374 P43234 529 4.6e-52 Cathepsin O OS=Homo sapiens GN=CTSO PE=2 SV=1 PF03051//PF00112//PF05739//PF05130//PF03661 Peptidase C1-like family//Papain family cysteine protease//SNARE domain//FlgN protein//Uncharacterised protein family (UPF0121) GO:0044780//GO:0006508 bacterial-type flagellum assembly//proteolysis GO:0004197//GO:0005515//GO:0008234 cysteine-type endopeptidase activity//protein binding//cysteine-type peptidase activity GO:0016021 integral component of membrane KOG1542 Cysteine proteinase Cathepsin F Cluster-8309.34576 BF_2 878.18 19.70 2152 646700389 KDR10550.1 1766 2.3e-194 V-type proton ATPase subunit C [Zootermopsis nevadensis] 571527272 XM_006562096.1 219 1.75996e-108 PREDICTED: Apis mellifera vacuolar H[+] ATPase 44kD C subunit (Vha44), transcript variant X2, mRNA K02148 ATPeV1C, ATP6C V-type H+-transporting ATPase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02148 Q9U5N1 1628 9.6e-180 V-type proton ATPase subunit C OS=Manduca sexta PE=2 SV=1 PF04799//PF04513//PF03223 fzo-like conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//V-ATPase subunit C GO:0015991//GO:0008053//GO:0015992 ATP hydrolysis coupled proton transport//mitochondrial fusion//proton transport GO:0003924//GO:0005198//GO:0015078 GTPase activity//structural molecule activity//hydrogen ion transmembrane transporter activity GO:0033180//GO:0019028//GO:0016021//GO:0019031//GO:0005741 proton-transporting V-type ATPase, V1 domain//viral capsid//integral component of membrane//viral envelope//mitochondrial outer membrane KOG2909 Vacuolar H+-ATPase V1 sector, subunit C Cluster-8309.34577 BF_2 149.21 2.78 2535 478257427 ENN77583.1 2415 1.5e-269 hypothetical protein YQE_05879, partial [Dendroctonus ponderosae]>gi|546685706|gb|ERL95167.1| hypothetical protein D910_12436 [Dendroctonus ponderosae] -- -- -- -- -- K00294 E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00294 P30038 1685 2.8e-186 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens GN=ALDH4A1 PE=1 SV=3 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase Cluster-8309.34578 BF_2 1709.73 40.00 2075 91094127 XP_968492.1 2115 7.6e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 3.3e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0030145//GO:0004177//GO:0008235 manganese ion binding//aminopeptidase activity//metalloexopeptidase activity GO:0005737//GO:0005622 cytoplasm//intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.34579 BF_2 4.00 0.71 524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34580 BF_2 476.89 33.15 889 211939884 ACJ13424.1 445 1.4e-41 serpin [Sphenophorus levis] -- -- -- -- -- K04525 SERPINA serpin peptidase inhibitor, clade A http://www.genome.jp/dbget-bin/www_bget?ko:K04525 P22922 299 5.1e-26 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34582 BF_2 6055.18 54.71 4917 546673472 ERL85070.1 2710 1.8e-303 hypothetical protein D910_02493 [Dendroctonus ponderosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 Q27772 2377 3.1e-266 C-1-tetrahydrofolate synthase, cytoplasmic OS=Spodoptera frugiperda PE=2 SV=3 PF01189//PF09445//PF02882//PF01795//PF05175//PF01268 16S rRNA methyltransferase RsmF//RNA cap guanine-N2 methyltransferase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//MraW methylase family//Methyltransferase small domain//Formate--tetrahydrofolate ligase GO:0055114//GO:0009396//GO:0046487//GO:0001510//GO:0009452 oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//RNA methylation//7-methylguanosine RNA capping GO:0008168//GO:0004488//GO:0003824//GO:0005524//GO:0004329 methyltransferase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//ATP binding//formate-tetrahydrofolate ligase activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.34584 BF_2 5.25 0.55 688 312306040 ADQ73873.1 532 9.1e-52 receptor for activated protein kinase C [Laodelphax striatella] -- -- -- -- -- K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 455 3.2e-44 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400//PF16974 WD domain, G-beta repeat//High-affinity nitrate transporter accessory GO:0010167//GO:0015706 response to nitrate//nitrate transport GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.34585 BF_2 84.75 0.98 3889 91089633 XP_973579.1 1641 1.3e-179 PREDICTED: guanine nucleotide-binding protein subunit beta-like protein isoform X1 [Tribolium castaneum]>gi|270012613|gb|EFA09061.1| hypothetical protein TcasGA2_TC006776 [Tribolium castaneum] 389610732 AK402355.1 167 2.58277e-79 Papilio polytes mRNA for receptor of activated protein kinase C 1, complete cds, sequence id: Pp-0111 K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1482 1.5e-162 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.34586 BF_2 1350934.00 10239.91 5806 3123007 Q05808.1 3676 0.0e+00 RecName: Full=Vitellogenin; Contains: RecName: Full=YP47; Contains: RecName: Full=YP160; Flags: Precursor [Anthonomus grandis]>gi|155708|gb|AAA27740.1| vitellogenin [Anthonomus grandis] -- -- -- -- -- -- -- -- -- Q05808 3676 0.0e+00 Vitellogenin OS=Anthonomus grandis GN=VTG PE=3 SV=1 PF04551//PF09172//PF01347 GcpE protein//Domain of unknown function (DUF1943)//Lipoprotein amino terminal region GO:0016114//GO:0055114//GO:0006869 terpenoid biosynthetic process//oxidation-reduction process//lipid transport GO:0046429//GO:0005319 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//lipid transporter activity -- -- -- -- Cluster-8309.34588 BF_2 2215.00 55.99 1942 91093052 XP_967459.1 2418 5.2e-270 PREDICTED: T-complex protein 1 subunit eta [Tribolium castaneum]>gi|270002664|gb|EEZ99111.1| hypothetical protein TcasGA2_TC005004 [Tribolium castaneum] 545560918 XM_003640315.2 61 1.07609e-20 PREDICTED: Canis lupus familiaris T-complex protein 1 subunit eta-like (LOC100856782), mRNA K09499 CCT7 T-complex protein 1 subunit eta http://www.genome.jp/dbget-bin/www_bget?ko:K09499 Q5ZJK8 2081 2.6e-232 T-complex protein 1 subunit eta OS=Gallus gallus GN=CCT7 PE=1 SV=1 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0361 Chaperonin complex component, TCP-1 eta subunit (CCT7) Cluster-8309.34590 BF_2 2932.68 86.47 1706 780582621 AJZ68869.1 1775 1.7e-195 nicotinic acetylcholine receptor alpha 10 [Leptinotarsa decemlineata] -- -- -- -- -- K04809 CHRNA7 nicotinic acetylcholine receptor alpha-7 http://www.genome.jp/dbget-bin/www_bget?ko:K04809 P48180 545 2.9e-54 Acetylcholine receptor subunit alpha-type acr-16 OS=Caenorhabditis elegans GN=acr-16 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3646 Acetylcholine receptor Cluster-8309.34592 BF_2 104.43 0.77 5970 642918534 XP_008191512.1 3568 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 2440 1.9e-273 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02480//PF16656//PF00041//PF13895//PF00018//PF16794//PF14604 Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//SH3 domain//Fibronectin-III type domain//Variant SH3 domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding GO:0016020 membrane -- -- Cluster-8309.34594 BF_2 1361.42 24.45 2616 91081923 XP_970724.1 1473 2.7e-160 PREDICTED: dnaJ homolog subfamily A member 2 [Tribolium castaneum]>gi|270007352|gb|EFA03800.1| hypothetical protein TcasGA2_TC013913 [Tribolium castaneum] 642921669 XM_965631.3 47 8.82761e-13 PREDICTED: Tribolium castaneum dnaJ homolog subfamily A member 2 (LOC659314), mRNA K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 O60884 1120 9.4e-121 DnaJ homolog subfamily A member 2 OS=Homo sapiens GN=DNAJA2 PE=1 SV=1 PF00684//PF01155//PF11023 DnaJ central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-ribbon containing domain GO:0009408//GO:0006457//GO:0006464//GO:0006260 response to heat//protein folding//cellular protein modification process//DNA replication GO:0016151//GO:0031072//GO:0005524//GO:0046872//GO:0051082 nickel cation binding//heat shock protein binding//ATP binding//metal ion binding//unfolded protein binding GO:0005887//GO:0005737 integral component of plasma membrane//cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.34596 BF_2 2610.00 321.25 627 546676782 ERL87728.1 287 2.1e-23 hypothetical protein D910_05118 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34597 BF_2 692.99 12.83 2546 642917018 XP_008199599.1 757 2.8e-77 PREDICTED: uncharacterized protein LOC661444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y530 373 3.8e-34 O-acetyl-ADP-ribose deacetylase 1 OS=Homo sapiens GN=OARD1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34598 BF_2 305.00 9.91 1574 625199970 XP_007641880.1 177 3.1e-10 PREDICTED: putative uncharacterized protein DDB_G0282133 isoform X1 [Cricetulus griseus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34600 BF_2 1759.33 71.46 1317 546681897 ERL91906.1 554 4.9e-54 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 364 2.2e-33 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34603 BF_2 65.17 0.43 6607 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.5e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF00023//PF13606//PF09266//PF01331//PF01279 Ankyrin repeat//Ankyrin repeat//Viral DNA topoisomerase I, N-terminal//mRNA capping enzyme, catalytic domain//Parathyroid hormone family GO:0006370//GO:0006265//GO:0007165//GO:0006397 7-methylguanosine mRNA capping//DNA topological change//signal transduction//mRNA processing GO:0003677//GO:0005179//GO:0003916//GO:0004484//GO:0005515 DNA binding//hormone activity//DNA topoisomerase activity//mRNA guanylyltransferase activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.34604 BF_2 1222.52 25.36 2304 642928317 XP_971226.2 1703 5.0e-187 PREDICTED: protein arginine N-methyltransferase 1 isoform X1 [Tribolium castaneum] 795023681 XM_012005633.1 138 2.01033e-63 PREDICTED: Vollenhovia emeryi protein arginine N-methyltransferase 1 (LOC105558112), transcript variant X2, mRNA K11434 PRMT1 protein arginine N-methyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11434 Q99873 1351 1.4e-147 Protein arginine N-methyltransferase 1 OS=Homo sapiens GN=PRMT1 PE=1 SV=2 PF05175//PF01135//PF08241//PF02390 Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase domain//Putative methyltransferase GO:0009451//GO:0006479//GO:0046500//GO:0008033//GO:0006400//GO:0008152//GO:0006464 RNA modification//protein methylation//S-adenosylmethionine metabolic process//tRNA processing//tRNA modification//metabolic process//cellular protein modification process GO:0004719//GO:0008176//GO:0008168 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.34605 BF_2 802.00 112.63 585 357625019 EHJ75575.1 277 2.9e-22 ribosomal protein L39 [Danaus plexippus] -- -- -- -- -- K02924 RP-L39e, RPL39 large subunit ribosomal protein L39e http://www.genome.jp/dbget-bin/www_bget?ko:K02924 Q962S4 271 5.9e-23 60S ribosomal protein L39 OS=Spodoptera frugiperda GN=RpL39 PE=3 SV=1 PF00832 Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0002 60s ribosomal protein L39 Cluster-8309.34606 BF_2 3594.18 32.09 4973 642938457 XP_008199811.1 4218 0.0e+00 PREDICTED: Niemann-Pick C1 protein isoform X2 [Tribolium castaneum] 657584210 XM_008298026.1 55 6.02846e-17 PREDICTED: Stegastes partitus Niemann-Pick disease, type C1 (npc1), transcript variant X2, mRNA K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 P56941 2274 2.7e-254 Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1 PF03176//PF02460//PF07677 MMPL family//Patched family//A-macroglobulin receptor GO:0007165 signal transduction GO:0008158 hedgehog receptor activity GO:0005576//GO:0016020 extracellular region//membrane KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.34609 BF_2 865.26 19.19 2173 642913197 XP_008201432.1 1434 7.4e-156 PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913199|ref|XP_008201433.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum]>gi|642913201|ref|XP_008201434.1| PREDICTED: fatty-acid amide hydrolase 2-B isoform X2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 790 1.4e-82 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.34613 BF_2 531.00 6.44 3736 664776039 XP_008507292.1 315 7.2e-26 PREDICTED: zinc finger protein 709-like isoform X1 [Equus przewalskii] 817207063 XM_012424074.1 162 1.4927e-76 PREDICTED: Orussus abietinus zinc finger protein 628 (LOC105699228), transcript variant X3, mRNA K09219 SCRT scratch http://www.genome.jp/dbget-bin/www_bget?ko:K09219 Q13360 288 4.0e-24 Zinc finger protein 177 OS=Homo sapiens GN=ZNF177 PE=1 SV=4 PF02892//PF13912//PF16622//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.34614 BF_2 814.71 6.14 5842 642915997 XP_008190849.1 3607 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 306 2.09165e-156 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 919 4.3e-97 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF07714//PF06293//PF00069//PF13895//PF00041//PF02480//PF16656 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Immunoglobulin domain//Fibronectin type III domain//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497//GO:0006468 riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0004672//GO:0046872//GO:0003993//GO:0016773//GO:0005515//GO:0005524 protein kinase activity//metal ion binding//acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//ATP binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.34615 BF_2 5359.00 276.14 1099 332372558 AEE61421.1 573 2.6e-56 unknown [Dendroctonus ponderosae] 755974447 XM_011309028.1 82 1.27394e-32 PREDICTED: Fopius arisanus troponin C, isoform 1-like (LOC105269052), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47947 525 3.9e-52 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF13202//PF08771//PF00036//PF11504//PF12763//PF13833//PF13405//PF13499 EF hand//Rapamycin binding domain//EF hand//Colicin Ia//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0005515//GO:0008144//GO:0005509 protein binding//drug binding//calcium ion binding GO:0016021 integral component of membrane KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.34616 BF_2 1985.00 64.18 1581 332373530 AEE61906.1 1598 5.2e-175 unknown [Dendroctonus ponderosae] 695145358 XM_009501769.1 74 5.17663e-28 PREDICTED: Phalacrocorax carbo polymerase (DNA-directed), delta interacting protein 2 (POLDIP2), partial mRNA K17809 POLDIP2 polymerase delta-interacting protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17809 Q91VA6 1137 6.1e-123 Polymerase delta-interacting protein 2 OS=Mus musculus GN=Poldip2 PE=2 SV=1 PF08755 Hemimethylated DNA-binding protein YccV like -- -- GO:0003677 DNA binding -- -- KOG4408 Putative Mg2+ and Co2+ transporter CorD Cluster-8309.34617 BF_2 2082.17 32.80 2943 189235372 XP_968511.2 1112 2.2e-118 PREDICTED: nucleobindin-2 [Tribolium castaneum]>gi|270004247|gb|EFA00695.1| hypothetical protein TcasGA2_TC003574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80303 492 7.0e-48 Nucleobindin-2 OS=Homo sapiens GN=NUCB2 PE=1 SV=2 PF13499//PF13405//PF13833//PF00036//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG3866 DNA-binding protein of the nucleobindin family Cluster-8309.34618 BF_2 634.91 13.01 2329 546684814 ERL94396.1 1115 7.7e-119 hypothetical protein D910_11675 [Dendroctonus ponderosae] 242003302 XM_002422642.1 118 2.66665e-52 Pediculus humanus corporis histone deacetylase complex subunit SAP30, putative, mRNA K03678 RRP45, EXOSC9 exosome complex component RRP45 http://www.genome.jp/dbget-bin/www_bget?ko:K03678 Q4QR75 726 4.1e-75 Exosome complex component RRP45 OS=Rattus norvegicus GN=Exosc9 PE=2 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.34620 BF_2 2972.65 85.83 1736 189238341 XP_966817.2 1777 9.9e-196 PREDICTED: sorting and assembly machinery component 50 homolog [Tribolium castaneum] -- -- -- -- -- K07277 SAM50, TOB55, bamA outer membrane protein insertion porin family http://www.genome.jp/dbget-bin/www_bget?ko:K07277 Q6PA35 910 1.4e-96 Sorting and assembly machinery component 50 homolog B OS=Xenopus laevis GN=samm50-b PE=2 SV=1 PF01103 Surface antigen -- -- -- -- GO:0019867 outer membrane KOG2602 Predicted cell surface protein homologous to bacterial outer membrane proteins Cluster-8309.34621 BF_2 50.50 0.56 4076 546680769 ERL90975.1 1094 3.7e-116 hypothetical protein D910_08317 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 254 3.8e-20 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34622 BF_2 60.41 0.77 3583 674656867 AIL26080.1 753 1.1e-76 muscle LIM protein, partial [Monochamus alternatus] 674656866 KJ872589.1 285 6.02988e-145 Monochamus alternatus muscle LIM protein mRNA, partial cds K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 531 2.6e-52 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.34624 BF_2 84.65 2.24 1868 478251528 ENN71990.1 1720 4.4e-189 hypothetical protein YQE_11281, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8E8 659 1.9e-67 Cysteine-rich protein 2-binding protein OS=Homo sapiens GN=CSRP2BP PE=1 SV=3 PF13673//PF02576//PF00130//PF00628//PF16866//PF00583//PF13508//PF08445 Acetyltransferase (GNAT) domain//Putative ribosome maturation factor RimP//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//PHD-finger//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967//GO:0035556//GO:0042274 acyl-carrier-protein biosynthetic process//intracellular signal transduction//ribosomal small subunit biogenesis GO:0016747//GO:0005515//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//N-acetyltransferase activity -- -- -- -- Cluster-8309.34625 BF_2 255.28 2.90 3967 270003759 EFA00207.1 1132 1.4e-120 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.73262e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.34626 BF_2 17.24 0.36 2311 91088343 XP_971105.1 967 1.1e-101 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] 755959155 XM_011306001.1 54 9.99882e-17 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 670 1.3e-68 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF01370//PF01781//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ribosomal L38e protein family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0042254//GO:0008152//GO:0006412 oxidation-reduction process//ribosome biogenesis//metabolic process//translation GO:0003735//GO:0000166//GO:0003824//GO:0050662//GO:0016491 structural constituent of ribosome//nucleotide binding//catalytic activity//coenzyme binding//oxidoreductase activity GO:0005622//GO:0005840 intracellular//ribosome KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.34629 BF_2 56.89 0.56 4535 340723524 XP_003400139.1 296 1.4e-23 PREDICTED: NF-kappa-B essential modulator [Bombus terrestris]>gi|808137173|ref|XP_012170874.1| PREDICTED: NF-kappa-B essential modulator [Bombus terrestris]>gi|808137175|ref|XP_012170875.1| PREDICTED: NF-kappa-B essential modulator [Bombus terrestris] -- -- -- -- -- -- -- -- -- O88522 176 4.7e-11 NF-kappa-B essential modulator OS=Mus musculus GN=Ikbkg PE=1 SV=2 PF06160//PF13912//PF07651//PF02183//PF08287//PF00096//PF10186//PF13851 Septation ring formation regulator, EzrA//C2H2-type zinc finger//ANTH domain//Homeobox associated leucine zipper//Spc19//Zinc finger, C2H2 type//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding GO:0010508//GO:0008608//GO:0006355//GO:0048870//GO:0000921 positive regulation of autophagy//attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated//cell motility//septin ring assembly GO:0046872//GO:0003700//GO:0043565//GO:0005543 metal ion binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//phospholipid binding GO:0005876//GO:0042729//GO:0005940//GO:0005667//GO:0031514//GO:0016021 spindle microtubule//DASH complex//septin ring//transcription factor complex//motile cilium//integral component of membrane -- -- Cluster-8309.34631 BF_2 18.56 1.07 1010 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34632 BF_2 4482.54 175.11 1358 817216753 XP_012284387.1 893 2.5e-93 PREDICTED: peroxiredoxin 1 [Orussus abietinus]>gi|817216756|ref|XP_012284388.1| PREDICTED: peroxiredoxin 1 [Orussus abietinus] 533529372 KC197034.1 70 7.41285e-26 Rhodeus uyekii peroxiredoxin 1 mRNA, complete cds K13279 PRDX1 peroxiredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13279 Q9V3P0 799 8.1e-84 Peroxiredoxin 1 OS=Drosophila melanogaster GN=Jafrac1 PE=1 SV=1 PF00578//PF08534//PF10417 AhpC/TSA family//Redoxin//C-terminal domain of 1-Cys peroxiredoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.34633 BF_2 11.00 0.77 883 51011534 AAT92176.1 931 6.3e-98 60S ribosomal protein L7A [Ixodes pacificus]>gi|67083827|gb|AAY66848.1| 60S ribosomal protein L7a [Ixodes scapularis] -- -- -- -- -- K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P32429 871 2.4e-92 60S ribosomal protein L7a OS=Gallus gallus GN=RPL7A PE=2 SV=2 -- -- GO:0042254 ribosome biogenesis -- -- GO:0005840 ribosome KOG3166 60S ribosomal protein L7A Cluster-8309.34634 BF_2 783.09 41.47 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34636 BF_2 17.00 2.09 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34637 BF_2 1547.28 8.75 7688 642918117 XP_008194070.1 4807 0.0e+00 PREDICTED: ALK tyrosine kinase receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 1478 8.5e-162 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF00069//PF00629//PF07714//PF00057 Protein kinase domain//MAM domain, meprin/A5/mu//Protein tyrosine kinase//Low-density lipoprotein receptor domain class A GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0016020 membrane KOG1095 Protein tyrosine kinase Cluster-8309.34638 BF_2 86.00 53.34 350 108794573 ABG20822.1 338 1.4e-29 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 266 1.3e-22 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.34639 BF_2 7673.14 55.48 6073 91090364 XP_968231.1 1683 2.8e-184 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 614 1.0e-61 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 PF04728//PF00097//PF02891//PF14634//PF13639//PF00351 Lipoprotein leucine-zipper//Zinc finger, C3HC4 type (RING finger)//MIZ/SP-RING zinc finger//zinc-RING finger domain//Ring finger domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0055114 oxidation-reduction process GO:0005515//GO:0046872//GO:0008270//GO:0016714 protein binding//metal ion binding//zinc ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0019867 outer membrane KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.34640 BF_2 36.87 0.52 3274 350419978 XP_003492359.1 3053 0.0e+00 PREDICTED: leucine-zipper-like transcriptional regulator 1 [Bombus impatiens] 527245427 XM_005140996.1 147 2.84775e-68 PREDICTED: Melopsittacus undulatus leucine-zipper-like transcription regulator 1 (LOC101875977), partial mRNA -- -- -- -- Q8N653 1423 8.6e-156 Leucine-zipper-like transcriptional regulator 1 OS=Homo sapiens GN=LZTR1 PE=1 SV=2 PF03089//PF11648//PF01344//PF00651//PF07646 Recombination activating protein 2//C-terminal domain of RIG-I//Kelch motif//BTB/POZ domain//Kelch motif GO:0006310 DNA recombination GO:0003677//GO:0005515//GO:0016817 DNA binding//protein binding//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus KOG0379 Kelch repeat-containing proteins Cluster-8309.34642 BF_2 85.11 0.68 5547 478253857 ENN74149.1 1354 3.6e-146 hypothetical protein YQE_09122, partial [Dendroctonus ponderosae] 642911071 XM_008202341.1 497 0 PREDICTED: Tribolium castaneum ELAV-like protein 4 (LOC659897), transcript variant X3, mRNA K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 A4QNI8 891 7.1e-94 ELAV-like protein 4 OS=Xenopus tropicalis GN=elavl4 PE=2 SV=1 PF01024//PF08777//PF00076//PF08675//PF16367 Colicin pore forming domain//RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain//RNA recognition motif GO:0006402//GO:0019835//GO:0050829//GO:0051252 mRNA catabolic process//cytolysis//defense response to Gram-negative bacterium//regulation of RNA metabolic process GO:0003723//GO:0046872//GO:0003676//GO:0004535 RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity GO:0016021//GO:0005634//GO:0005737 integral component of membrane//nucleus//cytoplasm KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.34643 BF_2 135.09 2.78 2318 91083815 XP_973428.1 297 5.5e-24 PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924518|ref|XP_008194328.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924520|ref|XP_008194329.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|270007930|gb|EFA04378.1| hypothetical protein TcasGA2_TC014676 [Tribolium castaneum] 242011614 XM_002426498.1 39 2.18643e-08 Pediculus humanus corporis hypothetical protein, mRNA K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 P45973 246 1.8e-19 Chromobox protein homolog 5 OS=Homo sapiens GN=CBX5 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.34645 BF_2 174.86 2.21 3598 242005288 XP_002423502.1 747 5.6e-76 beat protein, putative [Pediculus humanus corporis]>gi|212506606|gb|EEB10764.1| beat protein, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.34646 BF_2 17.26 0.32 2565 642920869 XP_008192593.1 2055 8.5e-228 PREDICTED: protein turtle isoform X8 [Tribolium castaneum] 642920870 XM_008194372.1 186 4.65052e-90 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X14, mRNA -- -- -- -- Q967D7 747 1.6e-77 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF00041//PF07353 Tissue factor//Fibronectin type III domain//Uroplakin II GO:0061024 membrane organization GO:0005515 protein binding GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.34647 BF_2 173.73 1.71 4525 642924813 XP_008194051.1 4008 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X3 [Tribolium castaneum] 749755570 XM_011141969.1 132 8.60654e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.7e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 PF01092//PF00569 Ribosomal protein S6e//Zinc finger, ZZ type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2372 Oxidation resistance protein Cluster-8309.34648 BF_2 690.00 8.77 3578 91079020 XP_974879.1 2869 0.0e+00 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q863B3 1618 2.3e-178 Staphylococcal nuclease domain-containing protein 1 OS=Bos taurus GN=SND1 PE=1 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.34651 BF_2 7316.24 109.00 3095 91077276 XP_974294.1 519 1.3e-49 PREDICTED: cytochrome b5 [Tribolium castaneum]>gi|270002076|gb|EEZ98523.1| hypothetical protein TcasGA2_TC001027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4N3 380 7.1e-35 Cytochrome b5 OS=Drosophila melanogaster GN=Cyt-b5 PE=2 SV=1 -- -- -- -- GO:0020037//GO:0046872 heme binding//metal ion binding -- -- KOG0537 Cytochrome b5 Cluster-8309.34652 BF_2 698.97 195.77 436 646721191 KDR22661.1 265 5.3e-21 Protein transport protein Sec61 subunit gamma [Zootermopsis nevadensis] -- -- -- -- -- K07342 SEC61G, SSS1, secE protein transport protein SEC61 subunit gamma and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K07342 Q7Z1B8 266 1.7e-22 Protein transport protein Sec61 subunit gamma OS=Gryllotalpa orientalis GN=SEC61G PE=3 SV=1 PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0016020 membrane KOG3498 Preprotein translocase, gamma subunit Cluster-8309.34654 BF_2 349.56 2.24 6828 642922371 XP_008193129.1 2275 7.0e-253 PREDICTED: insulin-like growth factor 2 mRNA-binding protein 1 isoform X1 [Tribolium castaneum] 817191053 XM_012415487.1 263 1.95874e-132 PREDICTED: Orussus abietinus insulin-like growth factor 2 mRNA-binding protein 1 (LOC105694624), transcript variant X2, mRNA K17391 IGF2BP1 insulin-like growth factor 2 mRNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17391 O88477 962 5.1e-102 Insulin-like growth factor 2 mRNA-binding protein 1 OS=Mus musculus GN=Igf2bp1 PE=1 SV=1 PF00013//PF13184//PF13014//PF00076//PF04061//PF07650 KH domain//NusA-like KH domain//KH domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ORMDL family//KH domain -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG2193 IGF-II mRNA-binding protein IMP, contains RRM and KH domains Cluster-8309.34655 BF_2 111.90 18.36 542 443709651 ELU04243.1 290 8.3e-24 hypothetical protein CAPTEDRAFT_219882 [Capitella teleta] -- -- -- -- -- -- -- -- -- Q868Z9 261 7.9e-22 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.34656 BF_2 38.93 0.97 1971 270010741 EFA07189.1 870 1.7e-90 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 703 1.6e-72 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.34657 BF_2 388.00 80.74 488 332374588 AEE62435.1 392 1.1e-35 unknown [Dendroctonus ponderosae]>gi|546684934|gb|ERL94516.1| hypothetical protein D910_11793 [Dendroctonus ponderosae] -- -- -- -- -- K17780 TIM8 mitochondrial import inner membrane translocase subunit TIM8 http://www.genome.jp/dbget-bin/www_bget?ko:K17780 Q9Y1A3 324 3.5e-29 Mitochondrial import inner membrane translocase subunit Tim8 OS=Drosophila melanogaster GN=Tim8 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3489 Mitochondrial import inner membrane translocase, subunit TIM8 Cluster-8309.34660 BF_2 636.76 4.13 6739 642919776 XP_008192060.1 5683 0.0e+00 PREDICTED: multidrug resistance-associated protein 7 [Tribolium castaneum] -- -- -- -- -- K05674 ABCC10 ATP-binding cassette, subfamily C (CFTR/MRP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05674 Q5T3U5 2041 3.9e-227 Multidrug resistance-associated protein 7 OS=Homo sapiens GN=ABCC10 PE=1 SV=1 PF03193//PF00005//PF13304//PF01926//PF00664//PF00004 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//ATPase family associated with various cellular activities (AAA) GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.34661 BF_2 5731.74 859.71 566 478255228 ENN75457.1 681 4.0e-69 hypothetical protein YQE_08007, partial [Dendroctonus ponderosae] 677286677 KJ930032.1 338 3.11957e-175 Monochamus alternatus ribosomal protein S15A (RpS15A) mRNA, complete cds K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 Q6XIM8 652 3.8e-67 40S ribosomal protein S15a OS=Drosophila yakuba GN=RpS15Aa PE=2 SV=3 PF00410 Ribosomal protein S8 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-8309.34662 BF_2 95.70 1.95 2341 91084337 XP_972793.1 670 3.1e-67 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 4.36043e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 476 4.0e-46 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 PF05478 Prominin GO:0006457 protein folding GO:0031072//GO:0051082 heat shock protein binding//unfolded protein binding GO:0016021 integral component of membrane KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.34663 BF_2 2.00 0.31 555 270006735 EFA03183.1 171 5.3e-10 hypothetical protein TcasGA2_TC013103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34666 BF_2 19.32 0.57 1713 642912151 XP_008200828.1 1158 5.9e-124 PREDICTED: uridine phosphorylase 1-like isoform X1 [Tribolium castaneum]>gi|270002489|gb|EEZ98936.1| hypothetical protein TcasGA2_TC004559 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 626 1.2e-63 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0009116//GO:0009166//GO:0006206 nucleoside metabolic process//nucleotide catabolic process//pyrimidine nucleobase metabolic process GO:0003824//GO:0004850 catalytic activity//uridine phosphorylase activity GO:0005737 cytoplasm KOG3728 Uridine phosphorylase Cluster-8309.34667 BF_2 139.56 1.50 4171 546671568 ERL83830.1 695 7.0e-70 hypothetical protein D910_01082, partial [Dendroctonus ponderosae] -- -- -- -- -- K17552 PPP1R10 protein phosphatase 1 regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K17552 O55000 234 8.2e-18 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Rattus norvegicus GN=Ppp1r10 PE=1 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.34668 BF_2 1414.11 16.32 3911 546671568 ERL83830.1 695 6.5e-70 hypothetical protein D910_01082, partial [Dendroctonus ponderosae] -- -- -- -- -- K17552 PPP1R10 protein phosphatase 1 regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K17552 O55000 234 7.7e-18 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Rattus norvegicus GN=Ppp1r10 PE=1 SV=1 PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.34669 BF_2 21511.29 288.25 3409 91081301 XP_968960.1 3902 0.0e+00 PREDICTED: glycogen phosphorylase [Tribolium castaneum]>gi|270006093|gb|EFA02541.1| hypothetical protein TcasGA2_TC008246 [Tribolium castaneum] 817087305 XM_012410997.1 451 0 PREDICTED: Athalia rosae glycogen phosphorylase (LOC105692065), mRNA K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 P11216 3201 0.0e+00 Glycogen phosphorylase, brain form OS=Homo sapiens GN=PYGB PE=1 SV=5 PF00343 Carbohydrate phosphorylase GO:0005975 carbohydrate metabolic process GO:0030170//GO:0008184 pyridoxal phosphate binding//glycogen phosphorylase activity -- -- KOG2099 Glycogen phosphorylase Cluster-8309.34672 BF_2 2617.19 49.36 2505 270006955 EFA03403.1 2958 0.0e+00 hypothetical protein TcasGA2_TC013390 [Tribolium castaneum] 347966055 XM_321614.4 107 3.74055e-46 Anopheles gambiae str. PEST AGAP001507-PA (AgaP_AGAP001507) mRNA, complete cds K13647 PLODN procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K13647 Q5U367 1892 2.7e-210 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 OS=Rattus norvegicus GN=Plod3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1971 Lysyl hydroxylase Cluster-8309.34673 BF_2 328.67 18.29 1039 817079505 XP_012262173.1 280 2.3e-22 PREDICTED: zinc finger protein 706-like [Athalia rosae]>gi|817079507|ref|XP_012262174.1| PREDICTED: zinc finger protein 706-like [Athalia rosae] 389609616 AK401798.1 81 4.32376e-32 Papilio xuthus mRNA for similar to CG15715, complete cds, sequence id: Px-1382 -- -- -- -- Q5ZMM5 201 1.4e-14 Zinc finger protein 706 OS=Gallus gallus GN=ZNF706 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4118 Uncharacterized conserved protein Cluster-8309.34675 BF_2 18.00 25.20 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34677 BF_2 208.00 12.97 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34679 BF_2 2421.00 28.36 3858 91076160 XP_966582.1 1501 2.2e-163 PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911736|ref|XP_008200719.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911739|ref|XP_008200720.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|642911741|ref|XP_008200721.1| PREDICTED: ubiquilin-1 [Tribolium castaneum]>gi|270014726|gb|EFA11174.1| hypothetical protein TcasGA2_TC004781 [Tribolium castaneum] 501299748 AK418324.1 84 3.53202e-33 Riptortus pedestris mRNA for ubiquilin 1,2, partial cds, sequence id: Rped-0553, expressed in midgut K04523 UBQLN, DSK2 ubiquilin http://www.genome.jp/dbget-bin/www_bget?ko:K04523 Q5R684 899 5.9e-95 Ubiquilin-1 OS=Pongo abelii GN=UBQLN1 PE=2 SV=1 PF01801//PF00240//PF06112 Cytomegalovirus glycoprotein L//Ubiquitin family//Gammaherpesvirus capsid protein GO:0016032 viral process GO:0005515 protein binding GO:0019028//GO:0019031 viral capsid//viral envelope KOG0010 Ubiquitin-like protein Cluster-8309.34680 BF_2 112.29 0.42 11455 642935540 XP_008198051.1 1716 7.8e-188 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X5 [Tribolium castaneum] 755889203 XM_005188558.2 102 1.04002e-42 PREDICTED: Musca domestica vesicular integral-membrane protein VIP36 (LOC101894935), mRNA K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q7L273 996 9.8e-106 BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens GN=KCTD9 PE=1 SV=1 PF00139//PF02214//PF03388//PF03120 Legume lectin domain//BTB/POZ domain//Legume-like lectin family//NAD-dependent DNA ligase OB-fold domain GO:0006260//GO:0006281//GO:0051260 DNA replication//DNA repair//protein homooligomerization GO:0030246//GO:0003911 carbohydrate binding//DNA ligase (NAD+) activity GO:0016020 membrane KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.34681 BF_2 444.18 2.21 8690 270014822 EFA11270.1 5242 0.0e+00 hypothetical protein TcasGA2_TC010805 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04689//PF03808//PF08074//PF04851//PF00176 DNA binding protein S1FA//Glycosyl transferase WecB/TagA/CpsF family//CHDCT2 (NUC038) domain//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain GO:0009058//GO:0006355 biosynthetic process//regulation of transcription, DNA-templated GO:0005524//GO:0016787//GO:0003677//GO:0016818//GO:0008270 ATP binding//hydrolase activity//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.34682 BF_2 1604.55 21.56 3401 642928069 XP_968571.3 1658 1.2e-181 PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|642928071|ref|XP_008200143.1| PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|270010871|gb|EFA07319.1| hypothetical protein TcasGA2_TC015912 [Tribolium castaneum] -- -- -- -- -- K01581 E4.1.1.17, ODC1, speC, speF ornithine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01581 P27117 1033 1.5e-110 Ornithine decarboxylase OS=Bos taurus GN=ODC1 PE=2 SV=1 PF00278//PF02784 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain GO:0006596 polyamine biosynthetic process GO:0003824 catalytic activity -- -- KOG0622 Ornithine decarboxylase Cluster-8309.34684 BF_2 5.26 0.38 873 478260464 ENN80184.1 268 4.8e-21 hypothetical protein YQE_03380, partial [Dendroctonus ponderosae]>gi|546674446|gb|ERL85820.1| hypothetical protein D910_03235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34685 BF_2 3.00 0.42 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34687 BF_2 900.35 11.19 3652 402535159 AFQ62106.1 841 7.2e-87 female-specific doublesex isoform f1 [Tribolium castaneum] 642928399 XR_511419.1 167 2.4239e-79 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 6.9e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF01104//PF00751 Bunyavirus non-structural protein NS-s//DM DNA binding domain GO:0016032//GO:0006355 viral process//regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.34688 BF_2 16457.70 269.37 2843 91086235 XP_966692.1 3707 0.0e+00 PREDICTED: transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum]>gi|270011017|gb|EFA07465.1| transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum] 817081112 XM_012407627.1 680 0 PREDICTED: Athalia rosae transitional endoplasmic reticulum ATPase TER94 (LOC105690094), transcript variant X2, mRNA K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7KN62 3444 0.0e+00 Transitional endoplasmic reticulum ATPase TER94 OS=Drosophila melanogaster GN=TER94 PE=1 SV=1 PF02562//PF06414//PF02367//PF03152//PF00931//PF01057//PF00158//PF01695//PF07728//PF00004//PF01637//PF02456//PF04851//PF00005//PF03266//PF07726//PF00910//PF01443//PF05496//PF06068//PF14532//PF07724//PF00437 PhoH-like protein//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Ubiquitin fusion degradation protein UFD1//NB-ARC domain//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Adenovirus IVa2 protein//Type III restriction enzyme, res subunit//ABC transporter//NTPase//ATPase family associated with various cellular activities (AAA)//RNA helicase//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein GO:0019079//GO:0019083//GO:0006281//GO:0006810//GO:0006355//GO:0006511//GO:0006310//GO:0002949 viral genome replication//viral transcription//DNA repair//transport//regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0016787//GO:0098519//GO:0008134//GO:0016887//GO:0016301//GO:0003723//GO:0003678//GO:0003677//GO:0043531//GO:0003724//GO:0009378//GO:0017111 ATP binding//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//ATPase activity//kinase activity//RNA binding//DNA helicase activity//DNA binding//ADP binding//RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0730 AAA+-type ATPase Cluster-8309.34689 BF_2 98.00 4.24 1254 642921081 XP_975078.2 890 5.1e-93 PREDICTED: anaphase-promoting complex subunit 10 [Tribolium castaneum] -- -- -- -- -- K03357 APC10, DOC1 anaphase-promoting complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03357 Q9V831 691 2.5e-71 Anaphase-promoting complex subunit 10 OS=Drosophila melanogaster GN=APC10 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3437 Anaphase-promoting complex (APC), subunit 10 Cluster-8309.34690 BF_2 2184.97 15.30 6260 642914541 XP_008201720.1 2081 2.0e-230 PREDICTED: organic cation transporter protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 857 7.1e-90 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF04847//PF00083//PF07690 Calcipressin//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0019722 transmembrane transport//calcium-mediated signaling GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.34691 BF_2 8.67 0.55 952 91081323 XP_970047.1 604 5.6e-60 PREDICTED: uncharacterized oxidoreductase C115.03 [Tribolium castaneum]>gi|270005200|gb|EFA01648.1| hypothetical protein TcasGA2_TC007219 [Tribolium castaneum] -- -- -- -- -- K00010 iolG myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00010 O05389 274 4.3e-23 Uncharacterized oxidoreductase YrbE OS=Bacillus subtilis (strain 168) GN=yrbE PE=3 SV=2 PF01408 Oxidoreductase family, NAD-binding Rossmann fold GO:0055114 oxidation-reduction process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.34692 BF_2 136.95 7.35 1067 91081323 XP_970047.1 1025 9.7e-109 PREDICTED: uncharacterized oxidoreductase C115.03 [Tribolium castaneum]>gi|270005200|gb|EFA01648.1| hypothetical protein TcasGA2_TC007219 [Tribolium castaneum] -- -- -- -- -- K00010 iolG myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00010 O05389 437 6.0e-42 Uncharacterized oxidoreductase YrbE OS=Bacillus subtilis (strain 168) GN=yrbE PE=3 SV=2 PF01408//PF02894 Oxidoreductase family, NAD-binding Rossmann fold//Oxidoreductase family, C-terminal alpha/beta domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.34695 BF_2 38.32 0.68 2657 642928066 XP_008200141.1 144 3.5e-06 PREDICTED: serine protease inhibitor I/II-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06524 NOA36 protein -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.34696 BF_2 22.99 1.85 806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34697 BF_2 7.00 1.16 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34699 BF_2 150.73 2.64 2678 642925731 XP_008201510.1 470 5.5e-44 PREDICTED: snRNA-activating protein complex subunit 1-like [Tribolium castaneum]>gi|270008917|gb|EFA05365.1| hypothetical protein TcasGA2_TC015530 [Tribolium castaneum] 830186132 XM_004692871.2 69 5.32254e-25 PREDICTED: Condylura cristata vesicle-associated membrane protein 1 (synaptobrevin 1) (VAMP1), mRNA K13505 VAMP3 vesicle-associated membrane protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13505 O02495 252 4.3e-20 Synaptobrevin-1 OS=Caenorhabditis elegans GN=snb-1 PE=1 SV=1 PF00957//PF13851//PF10717 Synaptobrevin//Growth-arrest specific micro-tubule binding//Occlusion-derived virus envelope protein ODV-E18 GO:0016192//GO:0048870 vesicle-mediated transport//cell motility -- -- GO:0016021//GO:0031514//GO:0019031 integral component of membrane//motile cilium//viral envelope KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.34700 BF_2 2.21 0.56 451 546685274 ERL94801.1 401 9.3e-37 hypothetical protein D910_12075, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34701 BF_2 120.02 1.54 3542 195447626 XP_002071298.1 274 3.9e-21 GK25716 [Drosophila willistoni]>gi|194167383|gb|EDW82284.1| GK25716 [Drosophila willistoni] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 P54352 248 1.7e-19 Ethanolamine kinase OS=Drosophila melanogaster GN=eas PE=1 SV=2 -- -- GO:0006796 phosphate-containing compound metabolic process GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.34702 BF_2 6.29 0.31 1128 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34703 BF_2 658.00 21.64 1559 642925338 XP_001814375.2 1958 9.2e-217 PREDICTED: probable anion transporter 2, chloroplastic [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q652N5 604 3.8e-61 Probable anion transporter 4, chloroplastic OS=Oryza sativa subsp. japonica GN=PHT4;4 PE=2 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.34704 BF_2 26.00 1.47 1026 194320502 ACF48469.1 782 1.4e-80 cathepsin L [Triatoma brasiliensis] 391338161 XM_003743382.1 43 5.67925e-11 PREDICTED: Metaseiulus occidentalis oryzain gamma chain-like (LOC100905919), mRNA K01371 CTSK cathepsin K http://www.genome.jp/dbget-bin/www_bget?ko:K01371 Q26636 712 7.5e-74 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.34707 BF_2 4978.65 45.38 4877 270001371 EEZ97818.1 1944 1.2e-214 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914992 XM_008192252.1 1023 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X4, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 O60506 1275 1.9e-138 Heterogeneous nuclear ribonucleoprotein Q OS=Homo sapiens GN=SYNCRIP PE=1 SV=2 PF00076//PF08675//PF16367//PF08777//PF00023//PF07648 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain//RNA recognition motif//RNA binding motif//Ankyrin repeat//Kazal-type serine protease inhibitor domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0005515//GO:0003723//GO:0046872//GO:0004535//GO:0003676 protein binding//RNA binding//metal ion binding//poly(A)-specific ribonuclease activity//nucleic acid binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.34708 BF_2 706.29 24.32 1502 270001371 EEZ97818.1 1186 2.9e-127 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914986 XM_008192248.1 413 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X1, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 Q7TMK9 769 2.7e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.34709 BF_2 178.58 2.05 3934 478252681 ENN73077.1 393 6.9e-35 hypothetical protein YQE_10281, partial [Dendroctonus ponderosae]>gi|546682841|gb|ERL92730.1| hypothetical protein D910_10040 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06859 Bicoid-interacting protein 3 (Bin3) -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.34711 BF_2 110.76 0.53 8990 270003434 EEZ99881.1 5772 0.0e+00 hypothetical protein TcasGA2_TC002665 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.81589e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.6e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF00023//PF01637//PF02376//PF13414//PF13639//PF07728//PF13606//PF00004 Ankyrin repeat//Archaeal ATPase//CUT domain//TPR repeat//Ring finger domain//AAA domain (dynein-related subfamily)//Ankyrin repeat//ATPase family associated with various cellular activities (AAA) -- -- GO:0005524//GO:0008270//GO:0003677//GO:0016887//GO:0005515 ATP binding//zinc ion binding//DNA binding//ATPase activity//protein binding -- -- -- -- Cluster-8309.34712 BF_2 2241.62 19.56 5082 826411269 XP_012542660.1 269 2.1e-20 PREDICTED: 23 kDa integral membrane protein-like [Monomorium pharaonis] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q26499 193 5.7e-13 23 kDa integral membrane protein OS=Schistosoma haematobium PE=2 SV=1 PF02076//PF01757//PF03600//PF04144//PF00335 Pheromone A receptor//Acyltransferase family//Citrate transporter//SCAMP family//Tetraspanin family GO:0055085//GO:0007186//GO:0007606//GO:0015031//GO:0019236 transmembrane transport//G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//protein transport//response to pheromone GO:0016747//GO:0004932 transferase activity, transferring acyl groups other than amino-acyl groups//mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.34715 BF_2 4671.51 89.94 2460 91090031 XP_967844.1 2473 2.8e-276 PREDICTED: V-type proton ATPase subunit B [Tribolium castaneum]>gi|270014269|gb|EFA10717.1| hypothetical protein TcasGA2_TC012133 [Tribolium castaneum] 9713 X64354.1 700 0 M.sexta mRNA for vacuolar ATPase subunit B K02147 ATPeV1B, ATP6B V-type H+-transporting ATPase subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02147 P31409 2463 1.6e-276 V-type proton ATPase subunit B OS=Drosophila melanogaster GN=Vha55 PE=2 SV=1 PF00306//PF00006//PF03893//PF02874 ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain//Lipase 3 N-terminal region//ATP synthase alpha/beta family, beta-barrel domain GO:0046034//GO:0015991//GO:0016042//GO:0015992 ATP metabolic process//ATP hydrolysis coupled proton transport//lipid catabolic process//proton transport GO:0005524//GO:0016820 ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033180//GO:0033178 proton-transporting V-type ATPase, V1 domain//proton-transporting two-sector ATPase complex, catalytic domain KOG1351 Vacuolar H+-ATPase V1 sector, subunit B Cluster-8309.34716 BF_2 20.69 0.31 3107 478257505 ENN77661.1 3265 0.0e+00 hypothetical protein YQE_05955, partial [Dendroctonus ponderosae] 195398740 XM_002057943.1 332 3.89557e-171 Drosophila virilis GJ15746 (Dvir\GJ15746), mRNA K12392 AP1B1 AP-1 complex subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12392 Q10567 1843 1.6e-204 AP-1 complex subunit beta-1 OS=Homo sapiens GN=AP1B1 PE=1 SV=2 PF02883//PF02985//PF09066//PF00514//PF08802//PF03094//PF01602 Adaptin C-terminal domain//HEAT repeat//Beta2-adaptin appendage, C-terminal sub-domain//Armadillo/beta-catenin-like repeat//Cytochrome B6-F complex Fe-S subunit//Mlo family//Adaptin N terminal region GO:0016192//GO:0006886//GO:0006952//GO:0006118//GO:0055114 vesicle-mediated transport//intracellular protein transport//defense response//obsolete electron transport//oxidation-reduction process GO:0051537//GO:0005515//GO:0009496 2 iron, 2 sulfur cluster binding//protein binding//plastoquinol--plastocyanin reductase activity GO:0009512//GO:0016021//GO:0042651//GO:0030131//GO:0030117 cytochrome b6f complex//integral component of membrane//thylakoid membrane//clathrin adaptor complex//membrane coat KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit Cluster-8309.34717 BF_2 2198.00 33.15 3061 478257505 ENN77661.1 3915 0.0e+00 hypothetical protein YQE_05955, partial [Dendroctonus ponderosae] 195398740 XM_002057943.1 488 0 Drosophila virilis GJ15746 (Dvir\GJ15746), mRNA K12392 AP1B1 AP-1 complex subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12392 Q10567 2480 2.2e-278 AP-1 complex subunit beta-1 OS=Homo sapiens GN=AP1B1 PE=1 SV=2 PF02883//PF02985//PF09066//PF08802//PF01602//PF03094//PF00514 Adaptin C-terminal domain//HEAT repeat//Beta2-adaptin appendage, C-terminal sub-domain//Cytochrome B6-F complex Fe-S subunit//Adaptin N terminal region//Mlo family//Armadillo/beta-catenin-like repeat GO:0006118//GO:0055114//GO:0016192//GO:0006886//GO:0006952 obsolete electron transport//oxidation-reduction process//vesicle-mediated transport//intracellular protein transport//defense response GO:0009496//GO:0051537//GO:0005515 plastoquinol--plastocyanin reductase activity//2 iron, 2 sulfur cluster binding//protein binding GO:0030117//GO:0009512//GO:0016021//GO:0042651//GO:0030131 membrane coat//cytochrome b6f complex//integral component of membrane//thylakoid membrane//clathrin adaptor complex KOG1061 Vesicle coat complex AP-1/AP-2/AP-4, beta subunit Cluster-8309.34718 BF_2 6713.15 579.21 772 91081145 XP_975558.1 993 3.6e-105 PREDICTED: 60S ribosomal protein L10a isoform X2 [Tribolium castaneum]>gi|270005283|gb|EFA01731.1| hypothetical protein TcasGA2_TC007324 [Tribolium castaneum] 264667338 GU120405.1 269 9.843e-137 Chrysomela tremulae ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 921 3.3e-98 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG1570 60S ribosomal protein L10A Cluster-8309.34719 BF_2 111.37 2.46 2181 283046732 NP_001164313.1 1426 6.3e-155 peroxidase precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 2.2e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.34722 BF_2 23.48 0.31 3466 642923323 XP_001814851.2 2046 1.3e-226 PREDICTED: transport and Golgi organization protein 6 [Tribolium castaneum]>gi|270007618|gb|EFA04066.1| hypothetical protein TcasGA2_TC014300 [Tribolium castaneum] 501297508 AK417956.1 85 8.81311e-34 Riptortus pedestris mRNA for NEDD8, putative, complete cds, sequence id: Rped-1360 -- -- -- -- P0C031 239 1.8e-18 Ubiquitin-NEDD8-like protein RUB2 OS=Oryza sativa subsp. japonica GN=RUB2 PE=2 SV=2 PF13443//PF00452//PF02985 Cro/C1-type HTH DNA-binding domain//Apoptosis regulator proteins, Bcl-2 family//HEAT repeat GO:0042981 regulation of apoptotic process GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding -- -- KOG0005 Ubiquitin-like protein Cluster-8309.34723 BF_2 32.82 2.22 905 642926225 XP_008194836.1 498 1.1e-47 PREDICTED: 60S ribosomal protein L22 [Tribolium castaneum]>gi|270009023|gb|EFA05471.1| hypothetical protein TcasGA2_TC015654 [Tribolium castaneum] 762137041 XM_011453508.1 50 6.40499e-15 PREDICTED: Crassostrea gigas 60S ribosomal protein L22-like (LOC105345379), mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 309 3.6e-27 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG3434 60S ribosomal protein L22 Cluster-8309.34726 BF_2 6562.41 817.34 623 478250208 ENN70711.1 561 3.6e-55 hypothetical protein YQE_12656, partial [Dendroctonus ponderosae]>gi|546683976|gb|ERL93710.1| hypothetical protein D910_10997 [Dendroctonus ponderosae] 805772113 XM_003701659.2 54 2.58838e-17 PREDICTED: Megachile rotundata protein lethal(2)essential for life-like (LOC100881460), mRNA K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 430 2.3e-41 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF04209//PF00525 homogentisate 1,2-dioxygenase//Alpha crystallin A chain, N terminal GO:0007423//GO:0055114//GO:0042207//GO:0006570//GO:0006559 sensory organ development//oxidation-reduction process//styrene catabolic process//tyrosine metabolic process//L-phenylalanine catabolic process GO:0005212//GO:0004411 structural constituent of eye lens//homogentisate 1,2-dioxygenase activity -- -- -- -- Cluster-8309.34729 BF_2 552.00 40.81 853 91089531 XP_966781.1 777 4.4e-80 PREDICTED: protein BUD31 homolog [Tribolium castaneum]>gi|270011373|gb|EFA07821.1| hypothetical protein TcasGA2_TC005390 [Tribolium castaneum] 665805374 XM_008552656.1 137 2.61066e-63 PREDICTED: Microplitis demolitor protein BUD31 homolog (LOC103573515), mRNA K12873 BUD31, G10 bud site selection protein 31 http://www.genome.jp/dbget-bin/www_bget?ko:K12873 Q962X9 754 8.4e-79 Protein BUD31 homolog OS=Branchiostoma belcheri PE=2 SV=1 PF01125 G10 protein -- -- -- -- GO:0005634 nucleus KOG3404 G10 protein/predicted nuclear transcription regulator Cluster-8309.3473 BF_2 9.24 0.39 1276 270011377 EFA07825.1 445 2.1e-41 hypothetical protein TcasGA2_TC005394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KM2 237 1.1e-18 Protein C10 OS=Bos taurus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34731 BF_2 578.00 31.01 1067 546674972 ERL86242.1 595 7.0e-59 hypothetical protein D910_03652 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZBE7 522 8.4e-52 Protein yippee-like 5 OS=Bos taurus GN=YPEL5 PE=2 SV=1 PF07127//PF01641//PF11648 Late nodulin protein//SelR domain//C-terminal domain of RIG-I GO:0009878//GO:0055114 nodule morphogenesis//oxidation-reduction process GO:0033743//GO:0016817//GO:0046872 peptide-methionine (R)-S-oxide reductase activity//hydrolase activity, acting on acid anhydrides//metal ion binding -- -- KOG3399 Predicted Yippee-type zinc-binding protein Cluster-8309.34732 BF_2 10.01 1.54 559 91093173 XP_967937.1 309 5.4e-26 PREDICTED: 40S ribosomal protein S21 [Tribolium castaneum]>gi|270012942|gb|EFA09390.1| hypothetical protein TcasGA2_TC004308 [Tribolium castaneum] -- -- -- -- -- K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4GXP2 301 1.9e-26 40S ribosomal protein S21 OS=Biphyllus lunatus GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-8309.34734 BF_2 1258.15 95.55 838 91091114 XP_966512.1 833 1.4e-86 PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|91091116|ref|XP_975893.1| PREDICTED: GTP-binding nuclear protein Ran [Tribolium castaneum]>gi|270014090|gb|EFA10538.1| hypothetical protein TcasGA2_TC012793 [Tribolium castaneum] 768428971 XM_011557345.1 188 1.14282e-91 PREDICTED: Plutella xylostella GTP-binding nuclear protein Ran (LOC105386728), mRNA K07936 RAN GTP-binding nuclear protein Ran http://www.genome.jp/dbget-bin/www_bget?ko:K07936 Q9VZ23 810 2.7e-85 GTP-binding nuclear protein Ran OS=Drosophila melanogaster GN=ran PE=1 SV=1 PF00071//PF04670//PF00910//PF00503//PF02367//PF03193//PF00025//PF01926//PF08477 Ras family//Gtr1/RagA G protein conserved region//RNA helicase//G-protein alpha subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Protein of unknown function, DUF258//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007186//GO:0002949//GO:0006184//GO:0007264//GO:0007165//GO:0006913//GO:0006886 G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification//obsolete GTP catabolic process//small GTPase mediated signal transduction//signal transduction//nucleocytoplasmic transport//intracellular protein transport GO:0005525//GO:0019001//GO:0004871//GO:0003724//GO:0003723//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//RNA helicase activity//RNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0005622 intracellular KOG0096 GTPase Ran/TC4/GSP1 (nuclear protein transport pathway), small G protein superfamily Cluster-8309.34735 BF_2 17.00 3.18 511 642938415 XP_008199791.1 291 6.0e-24 PREDICTED: coleoptericin-like [Tribolium castaneum]>gi|270015418|gb|EFA11866.1| hypothetical protein TcasGA2_TC005093 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81592 458 1.1e-44 Acaloleptin A OS=Acalolepta luxuriosa PE=1 SV=2 PF06286 Coleoptericin GO:0042742 defense response to bacterium -- -- GO:0005576 extracellular region -- -- Cluster-8309.34736 BF_2 360.00 10.76 1687 674304048 AIL23555.1 425 5.7e-39 microsomal glutathione S-transferase [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q8HZJ2 174 3.0e-11 Prostaglandin E synthase OS=Equus caballus GN=PTGES PE=2 SV=1 PF02109 DAD family GO:0018279 protein N-linked glycosylation via asparagine GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity GO:0008250//GO:0016021 oligosaccharyltransferase complex//integral component of membrane -- -- Cluster-8309.34737 BF_2 5668.87 174.90 1643 728418241 AIY68362.1 976 7.2e-103 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 485 2.5e-47 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.34740 BF_2 1350.52 11.27 5300 642935129 XP_008197899.1 458 2.7e-42 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- K14651 TAF15, NPL3 transcription initiation factor TFIID subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14651 Q27294 374 6.1e-34 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF00076//PF00641 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG1995 Conserved Zn-finger protein Cluster-8309.34742 BF_2 228.13 2.63 3911 642934648 XP_972393.2 1463 5.8e-159 PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934650|ref|XP_008197751.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum]>gi|642934652|ref|XP_008197752.1| PREDICTED: kelch-like protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10463 KLHL26 kelch-like protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10463 Q8BGY4 392 3.7e-36 Kelch-like protein 26 OS=Mus musculus GN=Klhl26 PE=2 SV=1 PF00651//PF07646//PF01344 BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34743 BF_2 403.23 5.31 3464 91080681 XP_975202.1 1354 2.2e-146 PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|642919555|ref|XP_008191921.1| PREDICTED: CCR4-NOT transcription complex subunit 7 [Tribolium castaneum]>gi|270005851|gb|EFA02299.1| hypothetical protein TcasGA2_TC007964 [Tribolium castaneum] 665800505 XM_008549999.1 212 2.21802e-104 PREDICTED: Microplitis demolitor CCR4-NOT transcription complex subunit 7 (LOC103571729), transcript variant X3, mRNA K12581 CNOT7_8, CAF1, POP2 CCR4-NOT transcription complex subunit 7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12581 Q9UIV1 1046 4.7e-112 CCR4-NOT transcription complex subunit 7 OS=Homo sapiens GN=CNOT7 PE=1 SV=3 PF04857//PF13482 CAF1 family ribonuclease//RNase_H superfamily -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG0304 mRNA deadenylase subunit Cluster-8309.34744 BF_2 700.00 16.38 2075 91093669 XP_969370.1 1982 2.0e-219 PREDICTED: phosphatidylserine synthase 1 [Tribolium castaneum]>gi|270008072|gb|EFA04520.1| hypothetical protein TcasGA2_TC016315 [Tribolium castaneum] 755857845 XM_011298312.1 116 3.06758e-51 PREDICTED: Musca domestica phosphatidylserine synthase 1 (LOC101896380), transcript variant X3, mRNA K08729 PTDSS1 phosphatidylserine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08729 Q5ZM65 1307 1.5e-142 Phosphatidylserine synthase 1 OS=Gallus gallus GN=PTDSS1 PE=2 SV=2 PF03034//PF01371 Phosphatidyl serine synthase//Trp repressor protein GO:0006355//GO:0006659 regulation of transcription, DNA-templated//phosphatidylserine biosynthetic process GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG2735 Phosphatidylserine synthase Cluster-8309.34745 BF_2 3912.94 84.60 2222 546682142 ERL92123.1 1937 3.6e-214 hypothetical protein D910_09443 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NFD2 274 1.0e-22 Ankyrin repeat and protein kinase domain-containing protein 1 OS=Homo sapiens GN=ANKK1 PE=2 SV=1 PF13606//PF00023//PF11616//PF07525 Ankyrin repeat//Ankyrin repeat//WD repeat binding protein EZH2//SOCS box GO:0006554//GO:0035556//GO:0006479 lysine catabolic process//intracellular signal transduction//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG4177 Ankyrin Cluster-8309.34746 BF_2 1916.30 406.85 484 727098952 AIY54301.1 682 2.6e-69 ribosomal protein L32e [Colaphellus bowringi] 727098951 KJ534560.1 204 8.17871e-101 Colaphellus bowringi ribosomal protein L32e (RPL32e) mRNA, complete cds K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q8WRF3 637 1.8e-65 60S ribosomal protein L32 OS=Apis mellifera GN=RpL32 PE=2 SV=1 PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0878 60S ribosomal protein L32 Cluster-8309.34747 BF_2 347.78 1.20 12451 642937614 XP_008199122.1 15377 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 792 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 5609 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF06701//PF02898//PF07236//PF00569 Mib_herc2//Nitric oxide synthase, oxygenase domain//Phytoreovirus S7 protein//Zinc finger, ZZ type GO:0055114//GO:0006809//GO:0016567 oxidation-reduction process//nitric oxide biosynthetic process//protein ubiquitination GO:0008270//GO:0046872//GO:0004517//GO:0004842 zinc ion binding//metal ion binding//nitric-oxide synthase activity//ubiquitin-protein transferase activity GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.34750 BF_2 845.00 33.32 1348 148469568 ABQ65713.1 181 9.0e-11 encapsulation-relating protein variant a [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06391 CDK-activating kinase assembly factor MAT1 GO:0007049 cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.34751 BF_2 39.77 0.83 2297 73921480 AAZ94270.1 1112 1.7e-118 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 698 7.1e-72 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF05529//PF00067 B-cell receptor-associated protein 31-like//Cytochrome P450 GO:0055114//GO:0006886 oxidation-reduction process//intracellular protein transport GO:0020037//GO:0005506//GO:0005488//GO:0016491//GO:0016705 heme binding//iron ion binding//binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane -- -- Cluster-8309.34754 BF_2 643.00 26.98 1284 270013885 EFA10333.1 858 2.7e-89 hypothetical protein TcasGA2_TC012551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4LDE5 185 1.2e-12 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Homo sapiens GN=SVEP1 PE=1 SV=3 PF05001//PF07271 RNA polymerase Rpb1 C-terminal repeat//Cytadhesin P30/P32 GO:0009405//GO:0006366//GO:0007157 pathogenesis//transcription from RNA polymerase II promoter//heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0003677 DNA binding GO:0016021//GO:0005665 integral component of membrane//DNA-directed RNA polymerase II, core complex -- -- Cluster-8309.34757 BF_2 4825.58 93.77 2440 91081923 XP_970724.1 1566 4.1e-171 PREDICTED: dnaJ homolog subfamily A member 2 [Tribolium castaneum]>gi|270007352|gb|EFA03800.1| hypothetical protein TcasGA2_TC013913 [Tribolium castaneum] 642921669 XM_965631.3 188 3.41745e-91 PREDICTED: Tribolium castaneum dnaJ homolog subfamily A member 2 (LOC659314), mRNA K09503 DNAJA2 DnaJ homolog subfamily A member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09503 O60884 1192 3.9e-129 DnaJ homolog subfamily A member 2 OS=Homo sapiens GN=DNAJA2 PE=1 SV=1 PF00684//PF01155//PF11023 DnaJ central domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-ribbon containing domain GO:0006260//GO:0009408//GO:0006457//GO:0006464 DNA replication//response to heat//protein folding//cellular protein modification process GO:0046872//GO:0051082//GO:0016151//GO:0031072//GO:0005524 metal ion binding//unfolded protein binding//nickel cation binding//heat shock protein binding//ATP binding GO:0005737//GO:0005887 cytoplasm//integral component of plasma membrane KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.34758 BF_2 778.45 89.01 653 282721116 NP_001164230.1 530 1.5e-51 mitochondrial acyl carrier protein 1 isoform B [Tribolium castaneum]>gi|270012710|gb|EFA09158.1| mitochondrial acyl carrier protein 1 isoform A [Tribolium castaneum] -- -- -- -- -- K03955 NDUFAB1 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03955 Q94519 311 1.5e-27 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 -- -- GO:0006633 fatty acid biosynthetic process -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-8309.34759 BF_2 508.96 51.95 697 270011246 EFA07694.1 449 3.9e-42 hypothetical protein TcasGA2_TC030783 [Tribolium castaneum] 642929327 XM_968543.2 196 3.36559e-96 PREDICTED: Tribolium castaneum protein krasavietz (LOC662449), mRNA -- -- -- -- Q9VNE2 351 3.7e-32 Protein krasavietz OS=Drosophila melanogaster GN=kra PE=1 SV=1 PF16782//PF02020 Nucleotide exchange factor SIL1//eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515//GO:0000774 protein binding//adenyl-nucleotide exchange factor activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.34760 BF_2 6363.61 59.89 4732 91094123 XP_968324.1 1235 1.9e-132 PREDICTED: zinc transporter 7 [Tribolium castaneum] 213521413 FJ430679.1 90 2.00483e-36 Lutzomyia shannoni clone LZ-A35 small ribosomal subunit S25 mRNA, complete cds K14692 SLC30A5_7, ZNT5_7, MTP, MSC2 solute carrier family 30 (zinc transporter), member 5/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14692 Q52KD7 474 1.4e-45 Zinc transporter 7-A OS=Xenopus laevis GN=slc30a7-a PE=2 SV=1 PF09302//PF06632//PF01325//PF01545 XLF-Cernunnos, XRcc4-like factor, NHEJ component//DNA double-strand break repair and V(D)J recombination protein XRCC4//Iron dependent repressor, N-terminal DNA binding domain//Cation efflux family GO:0006302//GO:0006812//GO:0006310//GO:0055085 double-strand break repair//cation transport//DNA recombination//transmembrane transport GO:0008324//GO:0003677 cation transmembrane transporter activity//DNA binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG1484 Putative Zn2+ transporter MSC2 (cation diffusion facilitator superfamily) Cluster-8309.34762 BF_2 1016.46 6.15 7205 642920483 XP_008192370.1 2835 0.0e+00 PREDICTED: liprin-beta-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K03680 EIF2B4 translation initiation factor eIF-2B subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K03680 Q63186 925 1.1e-97 Translation initiation factor eIF-2B subunit delta OS=Rattus norvegicus GN=Eif2b4 PE=2 SV=1 PF01008//PF01763//PF02198//PF00536//PF07647//PF01496//PF02601 Initiation factor 2 subunit family//Herpesvirus UL6 like//Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//V-type ATPase 116kDa subunit family//Exonuclease VII, large subunit GO:0015991//GO:0044237//GO:0006323//GO:0015992//GO:0006308 ATP hydrolysis coupled proton transport//cellular metabolic process//DNA packaging//proton transport//DNA catabolic process GO:0008855//GO:0005515//GO:0043565//GO:0015078 exodeoxyribonuclease VII activity//protein binding//sequence-specific DNA binding//hydrogen ion transmembrane transporter activity GO:0005634//GO:0033179//GO:0009318 nucleus//proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex KOG1467 Translation initiation factor 2B, delta subunit (eIF-2Bdelta/GCD2) Cluster-8309.34763 BF_2 51.00 1.98 1364 546682999 ERL92871.1 737 3.1e-75 hypothetical protein D910_10177 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34765 BF_2 481.60 3.47 6097 646718907 KDR21210.1 2675 2.6e-299 Calcium-transporting ATPase type 2C member 1 [Zootermopsis nevadensis] 701357390 XM_010007485.1 90 2.58758e-36 PREDICTED: Chaetura pelagica ATPase, Ca++ transporting, type 2C, member 1 (ATP2C1), mRNA K01537 E3.6.3.8 Ca2+-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01537 P57709 2088 1.2e-232 Calcium-transporting ATPase type 2C member 1 OS=Bos taurus GN=ATP2C1 PE=2 SV=1 PF06450//PF13912//PF16622//PF00122//PF00096 Bacterial Na+/H+ antiporter B (NhaB)//C2H2-type zinc finger//zinc-finger C2H2-type//E1-E2 ATPase//Zinc finger, C2H2 type GO:0015992//GO:0006814//GO:0006885 proton transport//sodium ion transport//regulation of pH GO:0046872//GO:0015385//GO:0000166 metal ion binding//sodium:proton antiporter activity//nucleotide binding GO:0016021 integral component of membrane KOG0202 Ca2+ transporting ATPase Cluster-8309.34768 BF_2 416.00 20.22 1148 189239759 XP_001807559.1 534 8.9e-52 PREDICTED: transcription factor MafK [Tribolium castaneum]>gi|270012669|gb|EFA09117.1| hypothetical protein TcasGA2_TC015977 [Tribolium castaneum] -- -- -- -- -- K09037 MAFF_G_K transcription factor MAFF/G/K http://www.genome.jp/dbget-bin/www_bget?ko:K09037 O60675 274 5.2e-23 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 PF04111//PF03131//PF00170//PF03404 Autophagy protein Apg6//bZIP Maf transcription factor//bZIP transcription factor//Mo-co oxidoreductase dimerisation domain GO:0006914//GO:0006355//GO:0055114 autophagy//regulation of transcription, DNA-templated//oxidation-reduction process GO:0003677//GO:0016491//GO:0030151//GO:0043565//GO:0003700 DNA binding//oxidoreductase activity//molybdenum ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.34770 BF_2 437.80 6.15 3265 478256311 ENN76501.1 492 1.9e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34771 BF_2 15.82 0.40 1926 642915176 XP_008190506.1 292 1.7e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34773 BF_2 176.34 2.64 3078 546682375 ERL92317.1 1068 2.9e-113 hypothetical protein D910_09634 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V771 749 1.2e-77 Probable cytochrome P450 6a23 OS=Drosophila melanogaster GN=Cyp6a23 PE=2 SV=2 PF00067//PF02428 Cytochrome P450//Potato type II proteinase inhibitor family GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0004867//GO:0016705 iron ion binding//heme binding//serine-type endopeptidase inhibitor activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.34774 BF_2 135.35 1.66 3699 91085981 XP_971976.1 3595 0.0e+00 PREDICTED: cullin-1 [Tribolium castaneum]>gi|642927556|ref|XP_008195314.1| PREDICTED: cullin-1 [Tribolium castaneum] -- -- -- -- -- K03347 CUL1, CDC53 cullin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03347 Q9WTX6 3029 0.0e+00 Cullin-1 OS=Mus musculus GN=Cul1 PE=1 SV=1 PF03965//PF00888 Penicillinase repressor//Cullin family GO:0045892//GO:0006511 negative regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process GO:0031625//GO:0003677 ubiquitin protein ligase binding//DNA binding -- -- KOG2166 Cullins Cluster-8309.34775 BF_2 1648.00 33.48 2346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34776 BF_2 321.18 2.32 6069 546674425 ERL85803.1 1221 1.0e-130 hypothetical protein D910_03219, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34777 BF_2 66.72 1.05 2941 478252250 ENN72678.1 169 4.8e-09 hypothetical protein YQE_10776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34778 BF_2 60.26 0.37 7043 546674425 ERL85803.1 1220 1.6e-130 hypothetical protein D910_03219, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34779 BF_2 2928.06 183.14 956 730049052 AIZ08896.1 464 9.7e-44 takeout, partial [Locusta migratoria] -- -- -- -- -- -- -- -- -- Q9VBV3 236 1.1e-18 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34780 BF_2 113.01 7.25 939 311063281 ADP65804.1 477 3.0e-45 hypothetical protein [Locusta migratoria] -- -- -- -- -- -- -- -- -- Q9VBV3 247 5.7e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34782 BF_2 26948.26 822.35 1658 55978158 AAV68692.1 1713 2.5e-188 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q2PQM7 1163 6.1e-126 Chitinase-like protein Idgf4 OS=Glossina morsitans morsitans GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.34783 BF_2 581.43 13.20 2130 645020577 XP_001608013.2 409 5.2e-37 PREDICTED: uncharacterized protein LOC100123516 isoform X2 [Nasonia vitripennis] 749773869 XM_011143970.1 77 1.50776e-29 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X2, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.34787 BF_2 48.30 0.37 5770 393010342 AFN02498.1 2025 5.8e-224 heat shock protein 90 [Tenebrio molitor] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 1.0e-215 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF00183//PF10510//PF11605//PF04857 Hsp90 protein//Phosphatidylinositol-glycan biosynthesis class S protein//Vacuolar protein sorting protein 36 Vps36//CAF1 family ribonuclease GO:0006950//GO:0006457//GO:0016255 response to stress//protein folding//attachment of GPI anchor to protein GO:0043130//GO:0005524//GO:0051082//GO:0032266 ubiquitin binding//ATP binding//unfolded protein binding//phosphatidylinositol-3-phosphate binding GO:0005634//GO:0042765 nucleus//GPI-anchor transamidase complex KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.34788 BF_2 3621.40 64.20 2647 642920332 XP_975626.2 1689 2.4e-185 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] 195397078 XM_002057120.1 100 3.07957e-42 Drosophila virilis GJ16936 (Dvir\GJ16936), mRNA -- -- -- -- Q6TYB5 554 4.1e-55 Fasciculation and elongation protein zeta-2 OS=Mus musculus GN=Fez2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.34789 BF_2 3824.93 803.93 486 751464756 XP_011187336.1 495 1.3e-47 PREDICTED: putative ATP synthase subunit f, mitochondrial [Bactrocera cucurbitae] -- -- -- -- -- K02130 ATPeF0F, ATP5J2 F-type H+-transporting ATPase subunit f http://www.genome.jp/dbget-bin/www_bget?ko:K02130 Q9W141 476 8.2e-47 Putative ATP synthase subunit f, mitochondrial OS=Drosophila melanogaster GN=CG4692 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4092 Mitochondrial F1F0-ATP synthase, subunit f Cluster-8309.3479 BF_2 9.00 0.88 715 270017036 EFA13482.1 235 2.6e-17 hypothetical protein TcasGA2_TC002033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34791 BF_2 373.00 5.08 3361 91088019 XP_974107.1 390 1.3e-34 PREDICTED: transcription factor A, mitochondrial [Tribolium castaneum]>gi|270012067|gb|EFA08515.1| hypothetical protein TcasGA2_TC006168 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4H0T5 227 4.3e-17 Transcription factor A, mitochondrial OS=Trachypithecus cristatus GN=TFAM PE=2 SV=1 PF05369//PF03612//PF04690 Monomethylamine methyltransferase MtmB//Sorbitol phosphotransferase enzyme II N-terminus//YABBY protein GO:0032259//GO:0008643//GO:0009401//GO:0007275 methylation//carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//multicellular organismal development GO:0008168//GO:0008982 methyltransferase activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357//GO:0016021 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.34793 BF_2 2081.50 25.60 3688 665816435 XP_008556934.1 2575 6.2e-288 PREDICTED: cartilage oligomeric matrix protein [Microplitis demolitor] -- -- -- -- -- K04659 THBS2S thrombospondin 2/3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04659 P49747 1741 1.3e-192 Cartilage oligomeric matrix protein OS=Homo sapiens GN=COMP PE=1 SV=2 PF02412//PF05735//PF07645//PF00008//PF03327 Thrombospondin type 3 repeat//Thrombospondin C-terminal region//Calcium-binding EGF domain//EGF-like domain//Herpesvirus capsid shell protein VP19C GO:0007155//GO:0019069 cell adhesion//viral capsid assembly GO:0003677//GO:0005509//GO:0005515 DNA binding//calcium ion binding//protein binding GO:0005576 extracellular region KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.34794 BF_2 90.18 2.07 2107 270010810 EFA07258.1 310 1.5e-25 hypothetical protein TcasGA2_TC013289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34797 BF_2 415.40 15.46 1411 91088325 XP_970263.1 1720 3.3e-189 PREDICTED: GTP-binding protein 128up [Tribolium castaneum]>gi|270011791|gb|EFA08239.1| hypothetical protein TcasGA2_TC005867 [Tribolium castaneum] 527259203 XM_005147801.1 223 6.83616e-111 PREDICTED: Melopsittacus undulatus developmentally regulated GTP binding protein 1 (LOC101878172), mRNA -- -- -- -- P32234 1604 3.8e-177 GTP-binding protein 128up OS=Drosophila melanogaster GN=128up PE=2 SV=2 PF02421//PF01926 Ferrous iron transport protein B//50S ribosome-binding GTPase GO:0015684 ferrous iron transport GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG1487 GTP-binding protein DRG1 (ODN superfamily) Cluster-8309.34798 BF_2 620.48 7.37 3809 91083579 XP_968212.1 2350 7.9e-262 PREDICTED: lysine--tRNA ligase isoform X2 [Tribolium castaneum]>gi|270007824|gb|EFA04272.1| hypothetical protein TcasGA2_TC014562 [Tribolium castaneum] 157106532 XM_001649316.1 207 1.46925e-101 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1951 6.0e-217 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01336//PF01409//PF17121//PF00152 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//Zinc finger, C3HC4 type (RING finger)//tRNA synthetases class II (D, K and N) GO:0006418//GO:0043039//GO:0006430//GO:0009085 tRNA aminoacylation for protein translation//tRNA aminoacylation//lysyl-tRNA aminoacylation//lysine biosynthetic process GO:0000166//GO:0008270//GO:0003676//GO:0004812//GO:0005524//GO:0005515//GO:0000049//GO:0004824 nucleotide binding//zinc ion binding//nucleic acid binding//aminoacyl-tRNA ligase activity//ATP binding//protein binding//tRNA binding//lysine-tRNA ligase activity GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.34799 BF_2 759.25 14.34 2502 91095137 XP_972151.1 803 1.3e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.1098e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.4e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.34800 BF_2 424.18 7.96 2517 642916311 XP_008190969.1 767 1.9e-78 PREDICTED: nurim homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q296J9 414 6.6e-39 Nurim homolog OS=Drosophila pseudoobscura pseudoobscura GN=nrm PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34801 BF_2 36.82 0.70 2498 642916311 XP_008190969.1 708 1.3e-71 PREDICTED: nurim homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q296J9 401 2.1e-37 Nurim homolog OS=Drosophila pseudoobscura pseudoobscura GN=nrm PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34802 BF_2 4415.25 74.48 2767 642930232 XP_008196309.1 2918 0.0e+00 PREDICTED: unc-112-related protein-like isoform X1 [Tribolium castaneum]>gi|270010684|gb|EFA07132.1| hypothetical protein TcasGA2_TC010123 [Tribolium castaneum] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 2148 6.2e-240 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 -- -- -- -- GO:0005543 phospholipid binding -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.34806 BF_2 10.00 1.01 702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34807 BF_2 991.29 18.17 2569 91080939 XP_974274.1 791 3.2e-81 PREDICTED: signal peptidase complex subunit 3 [Tribolium castaneum]>gi|270005949|gb|EFA02397.1| hypothetical protein TcasGA2_TC008077 [Tribolium castaneum] -- -- -- -- -- K12948 SPCS3, SPC3 signal peptidase complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12948 Q9VCA9 701 3.6e-72 Signal peptidase complex subunit 3 OS=Drosophila melanogaster GN=Spase22-23 PE=2 SV=1 PF03493//PF03468//PF07544//PF02372//PF02601//PF04573//PF08519 Calcium-activated BK potassium channel alpha subunit//XS domain//RNA polymerase II transcription mediator complex subunit 9//Interleukin 15//Exonuclease VII, large subunit//Signal peptidase subunit//Replication factor RFC1 C terminal domain GO:0006955//GO:0006260//GO:0006357//GO:0031047//GO:0007165//GO:0006308//GO:0006465//GO:0006813 immune response//DNA replication//regulation of transcription from RNA polymerase II promoter//gene silencing by RNA//signal transduction//DNA catabolic process//signal peptide processing//potassium ion transport GO:0003689//GO:0005126//GO:0008233//GO:0005524//GO:0015269//GO:0001104//GO:0008855 DNA clamp loader activity//cytokine receptor binding//peptidase activity//ATP binding//calcium-activated potassium channel activity//RNA polymerase II transcription cofactor activity//exodeoxyribonuclease VII activity GO:0009318//GO:0005787//GO:0016021//GO:0042575//GO:0005663//GO:0016020//GO:0005576//GO:0016592 exodeoxyribonuclease VII complex//signal peptidase complex//integral component of membrane//DNA polymerase complex//DNA replication factor C complex//membrane//extracellular region//mediator complex KOG3372 Signal peptidase complex subunit Cluster-8309.34810 BF_2 139.20 4.79 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04210 Tetrahydromethanopterin S-methyltransferase, subunit G GO:0015948//GO:0046656 methanogenesis//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.34812 BF_2 363.86 3.32 4873 91085983 XP_972029.1 1888 3.8e-208 PREDICTED: TBC1 domain family member 31 [Tribolium castaneum]>gi|270010179|gb|EFA06627.1| hypothetical protein TcasGA2_TC009546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DN5 1045 8.7e-112 TBC1 domain family member 31 OS=Homo sapiens GN=TBC1D31 PE=2 SV=2 PF00156//PF03091//PF06689//PF03310 Phosphoribosyl transferase domain//CutA1 divalent ion tolerance protein//ClpX C4-type zinc finger//Caulimovirus DNA-binding protein GO:0010038//GO:0009116 response to metal ion//nucleoside metabolic process GO:0008270//GO:0003677//GO:0046983 zinc ion binding//DNA binding//protein dimerization activity -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-8309.34813 BF_2 348.32 5.42 2977 642917564 XP_008191258.1 2874 0.0e+00 PREDICTED: NF-X1-type zinc finger protein NFXL1 [Tribolium castaneum] -- -- -- -- -- K15683 NFXL1, OZFP NF-X1-type zinc finger protein NFXL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15683 Q6ZNB6 1845 9.1e-205 NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens GN=NFXL1 PE=1 SV=2 PF01422//PF08771 NF-X1 type zinc finger//Rapamycin binding domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003700//GO:0008144 zinc ion binding//transcription factor activity, sequence-specific DNA binding//drug binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.34814 BF_2 1582.22 28.23 2632 270004742 EFA01190.1 2045 1.3e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 8.7e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006090//GO:0071436//GO:0006814//GO:0006525//GO:0006560 pyruvate metabolic process//sodium ion export//sodium ion transport//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.34815 BF_2 303.80 10.46 1502 642922684 XP_008193279.1 497 2.3e-47 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X11 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 224 4.3e-17 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF00057//PF10717 Low-density lipoprotein receptor domain class A//Occlusion-derived virus envelope protein ODV-E18 -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.34816 BF_2 198.80 6.66 1535 642922680 XP_008193277.1 347 5.8e-30 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X9 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 224 4.4e-17 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF00057//PF10717 Low-density lipoprotein receptor domain class A//Occlusion-derived virus envelope protein ODV-E18 -- -- GO:0005515 protein binding GO:0019031 viral envelope KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.34819 BF_2 223.13 5.50 1983 642920402 XP_008192333.1 471 3.1e-44 PREDICTED: uncharacterized protein LOC664268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34820 BF_2 3315.92 161.89 1144 91090754 XP_968387.1 801 9.8e-83 PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935819|ref|XP_008198188.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935821|ref|XP_008198189.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|270013960|gb|EFA10408.1| hypothetical protein TcasGA2_TC012647 [Tribolium castaneum] 642935820 XM_008199967.1 264 8.91003e-134 PREDICTED: Tribolium castaneum ADP-ribosylation factor 1 (LOC656788), transcript variant X3, mRNA K07937 ARF1 ADP-ribosylation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07937 P61209 794 2.6e-83 ADP-ribosylation factor 1 OS=Drosophila melanogaster GN=Arf79F PE=2 SV=2 PF01926//PF08477//PF04670//PF00025//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//G-protein alpha subunit GO:0007264//GO:0007186//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0003924//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//GTPase activity//G-protein beta/gamma-subunit complex binding GO:0005622 intracellular KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.34821 BF_2 11.16 0.33 1717 642925622 XP_008194644.1 1028 7.0e-109 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 1 [Tribolium castaneum]>gi|270008661|gb|EFA05109.1| hypothetical protein TcasGA2_TC015209 [Tribolium castaneum] 505853271 XM_004620012.1 39 1.61085e-08 PREDICTED: Sorex araneus polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV20 487 1.6e-47 Polypeptide N-acetylgalactosaminyltransferase 1 OS=Drosophila melanogaster GN=GalNAc-T1 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.34824 BF_2 56.52 0.66 3857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34825 BF_2 22.00 2.75 622 546683491 ERL93297.1 202 1.5e-13 hypothetical protein D910_10592 [Dendroctonus ponderosae] 642939025 XR_511766.1 46 7.23545e-13 PREDICTED: Tribolium castaneum ATP-dependent RNA helicase p62 (Rm62), transcript variant X2, misc_RNA K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 A5A6J2 178 3.8e-12 Probable ATP-dependent RNA helicase DDX5 OS=Pan troglodytes GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.34826 BF_2 22.00 2.75 622 546683491 ERL93297.1 202 1.5e-13 hypothetical protein D910_10592 [Dendroctonus ponderosae] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 A5A6J2 178 3.8e-12 Probable ATP-dependent RNA helicase DDX5 OS=Pan troglodytes GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.34827 BF_2 143.36 1.32 4846 642916747 XP_972619.2 2490 5.8e-278 PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916749|ref|XP_008192467.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916751|ref|XP_008192470.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04422 MAP3K13, LZK mitogen-activated protein kinase kinase kinase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K04422 Q12852 1037 7.3e-111 Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG4721 Serine/threonine protein kinase, contains leucine zipper domain Cluster-8309.34830 BF_2 603.51 4.41 6008 642911450 XP_973171.3 2535 4.4e-283 PREDICTED: cullin-associated NEDD8-dissociated protein 1 [Tribolium castaneum]>gi|270014883|gb|EFA11331.1| hypothetical protein TcasGA2_TC010870 [Tribolium castaneum] -- -- -- -- -- K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 2076 3.0e-231 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985//PF08064//PF07571//PF11698//PF01602//PF00443//PF07062//PF00790 HEAT repeat//UME (NUC010) domain//TAF6 C-terminal HEAT repeat domain//V-ATPase subunit H//Adaptin N terminal region//Ubiquitin carboxyl-terminal hydrolase//Clc-like//VHS domain GO:0016192//GO:0016310//GO:0051090//GO:0015991//GO:0006886//GO:0009069//GO:0016579 vesicle-mediated transport//phosphorylation//regulation of sequence-specific DNA binding transcription factor activity//ATP hydrolysis coupled proton transport//intracellular protein transport//serine family amino acid metabolic process//protein deubiquitination GO:0036459//GO:0005515//GO:0016820//GO:0004674 ubiquitinyl hydrolase activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein serine/threonine kinase activity GO:0016021//GO:0005634//GO:0000221//GO:0030117 integral component of membrane//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain//membrane coat KOG1824 TATA-binding protein-interacting protein Cluster-8309.34832 BF_2 342.12 11.16 1569 642934971 XP_008196003.1 1679 2.1e-184 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] -- -- -- -- -- K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 Q8WY54 679 7.7e-70 Protein phosphatase 1E OS=Homo sapiens GN=PPM1E PE=1 SV=2 PF07228//PF01090//PF00481 Stage II sporulation protein E (SpoIIE)//Ribosomal protein S19e//Protein phosphatase 2C GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840 ribosome KOG0698 Serine/threonine protein phosphatase Cluster-8309.34833 BF_2 4592.60 45.18 4539 642915997 XP_008190849.1 4040 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 381 0 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 1194 4.3e-129 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF13895//PF00041//PF16656//PF02480//PF07714//PF06293//PF00069 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0019497//GO:0006771 protein phosphorylation//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0046872//GO:0016773//GO:0003993 protein binding//ATP binding//protein kinase activity//metal ion binding//phosphotransferase activity, alcohol group as acceptor//acid phosphatase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.34834 BF_2 73.00 2.32 1604 478250168 ENN70671.1 1344 1.5e-145 hypothetical protein YQE_12616, partial [Dendroctonus ponderosae]>gi|478270479|gb|ENN83517.1| hypothetical protein YQE_00124, partial [Dendroctonus ponderosae] -- -- -- -- -- K10348 LRR1, PPIL5 LRR-repeat protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10348 Q96L50 475 3.6e-46 Leucine-rich repeat protein 1 OS=Homo sapiens GN=LRR1 PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.34837 BF_2 260.00 6.19 2043 642917560 XP_008191257.1 1405 1.6e-152 PREDICTED: F-box only protein 25 [Tribolium castaneum] 642917559 XM_008193035.1 256 4.51189e-129 PREDICTED: Tribolium castaneum F-box only protein 25 (LOC659307), mRNA K10305 FBXO25_32 F-box protein 25/32 http://www.genome.jp/dbget-bin/www_bget?ko:K10305 Q1RMS8 382 2.8e-35 F-box only protein 25 OS=Bos taurus GN=FBXO25 PE=2 SV=1 PF00646//PF05864//PF12937//PF01194 F-box domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//F-box-like//RNA polymerases N / 8 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005515 DNA binding//DNA-directed RNA polymerase activity//protein binding GO:0005730 nucleolus KOG3497 DNA-directed RNA polymerase, subunit RPB10 Cluster-8309.34839 BF_2 20.11 0.33 2856 91083931 XP_974830.1 737 6.4e-75 PREDICTED: N-acetylserotonin O-methyltransferase-like protein [Tribolium castaneum]>gi|270007966|gb|EFA04414.1| hypothetical protein TcasGA2_TC014714 [Tribolium castaneum] -- -- -- -- -- K06287 maf septum formation protein http://www.genome.jp/dbget-bin/www_bget?ko:K06287 Q5KWN2 293 8.1e-25 Septum formation protein Maf OS=Geobacillus kaustophilus (strain HTA426) GN=maf PE=3 SV=1 PF02545//PF15937 Maf-like protein//prlF antitoxin for toxin YhaV_toxin GO:0001558 regulation of cell growth GO:0097351//GO:0003700 toxin-antitoxin pair type II binding//transcription factor activity, sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG1509 Predicted nucleic acid-binding protein ASMTL Cluster-8309.34840 BF_2 733.42 6.46 5035 642912047 XP_008199070.1 2587 3.4e-289 PREDICTED: nuclear factor 1 C-type isoform X1 [Tribolium castaneum]>gi|270014496|gb|EFA10944.1| hypothetical protein TcasGA2_TC001775 [Tribolium castaneum] 642912046 XM_008200848.1 750 0 PREDICTED: Tribolium castaneum nuclear factor 1 C-type (LOC660261), transcript variant X1, mRNA K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 P09414 752 8.5e-78 Nuclear factor 1 A-type OS=Rattus norvegicus GN=Nfia PE=1 SV=2 PF03165//PF00859 MH1 domain//CTF/NF-I family transcription modulation region GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634//GO:0005622 transcription factor complex//nucleus//intracellular KOG3663 Nuclear factor I Cluster-8309.34842 BF_2 276.44 9.92 1453 642928117 XP_008200164.1 422 1.1e-38 PREDICTED: protein anoxia up-regulated isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34845 BF_2 257.11 8.83 1505 270002788 EEZ99235.1 589 4.9e-58 serpin peptidase inhibitor 1 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 417 1.8e-39 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34846 BF_2 68.90 0.45 6763 189234221 XP_972511.2 927 1.4e-96 PREDICTED: zinc finger C4H2 domain-containing protein isoform X1 [Tribolium castaneum] 752869764 XM_011253703.1 65 2.2667e-22 PREDICTED: Camponotus floridanus zinc finger C4H2 domain-containing protein (LOC105248746), transcript variant X4, mRNA -- -- -- -- Q9NQZ6 480 4.0e-46 Zinc finger C4H2 domain-containing protein OS=Homo sapiens GN=ZC4H2 PE=1 SV=1 PF00769//PF03229//PF03854//PF02251 Ezrin/radixin/moesin family//Alphavirus glycoprotein J//P-11 zinc finger//Proteasome activator pa28 alpha subunit GO:0019050 suppression by virus of host apoptotic process GO:0008270//GO:0008092//GO:0003723 zinc ion binding//cytoskeletal protein binding//RNA binding GO:0008537//GO:0005737//GO:0019898 proteasome activator complex//cytoplasm//extrinsic component of membrane -- -- Cluster-8309.34847 BF_2 14.21 0.44 1629 91083633 XP_970446.1 1570 9.4e-172 PREDICTED: isocitrate dehydrogenase [NADP], mitochondrial [Tribolium castaneum]>gi|270007851|gb|EFA04299.1| hypothetical protein TcasGA2_TC014590 [Tribolium castaneum] 254582836 XM_002499105.1 82 1.90612e-32 Zygosaccharomyces rouxii hypothetical protein (ZYRO0E05016g) mRNA, complete cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P54071 1284 5.6e-140 Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus GN=Idh2 PE=1 SV=3 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0044237//GO:0055114 cellular metabolic process//oxidation-reduction process GO:0046872//GO:0016616 metal ion binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.34848 BF_2 9.00 0.60 910 91083633 XP_970446.1 331 2.5e-28 PREDICTED: isocitrate dehydrogenase [NADP], mitochondrial [Tribolium castaneum]>gi|270007851|gb|EFA04299.1| hypothetical protein TcasGA2_TC014590 [Tribolium castaneum] -- -- -- -- -- K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 Q04467 304 1.4e-26 Isocitrate dehydrogenase [NADP], mitochondrial OS=Bos taurus GN=IDH2 PE=1 SV=2 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0006099//GO:0055114//GO:0006749//GO:0006102//GO:0019643 tricarboxylic acid cycle//oxidation-reduction process//glutathione metabolic process//isocitrate metabolic process//reductive tricarboxylic acid cycle GO:0004450//GO:0000287//GO:0051287//GO:0016616 isocitrate dehydrogenase (NADP+) activity//magnesium ion binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.34849 BF_2 3352.78 117.38 1482 91083633 XP_970446.1 1855 7.6e-205 PREDICTED: isocitrate dehydrogenase [NADP], mitochondrial [Tribolium castaneum]>gi|270007851|gb|EFA04299.1| hypothetical protein TcasGA2_TC014590 [Tribolium castaneum] 254582836 XM_002499105.1 96 2.85479e-40 Zygosaccharomyces rouxii hypothetical protein (ZYRO0E05016g) mRNA, complete cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P54071 1580 2.4e-174 Isocitrate dehydrogenase [NADP], mitochondrial OS=Mus musculus GN=Idh2 PE=1 SV=3 PF00180 Isocitrate/isopropylmalate dehydrogenase GO:0055114//GO:0006099//GO:0019643//GO:0006102//GO:0006749 oxidation-reduction process//tricarboxylic acid cycle//reductive tricarboxylic acid cycle//isocitrate metabolic process//glutathione metabolic process GO:0000287//GO:0004450//GO:0016616//GO:0051287 magnesium ion binding//isocitrate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.34850 BF_2 1626.13 51.23 1615 91085239 XP_973002.1 1673 1.1e-183 PREDICTED: 26S proteasome non-ATPase regulatory subunit 13 [Tribolium castaneum]>gi|270009093|gb|EFA05541.1| hypothetical protein TcasGA2_TC015728 [Tribolium castaneum] -- -- -- -- -- K03039 PSMD13, RPN9 26S proteasome regulatory subunit N9 http://www.genome.jp/dbget-bin/www_bget?ko:K03039 P84169 999 6.2e-107 26S proteasome non-ATPase regulatory subunit 13 OS=Gallus gallus GN=PSMD13 PE=1 SV=1 PF00616//PF01399 GTPase-activator protein for Ras-like GTPase//PCI domain GO:0043087 regulation of GTPase activity GO:0005515 protein binding -- -- KOG2908 26S proteasome regulatory complex, subunit RPN9/PSMD13 Cluster-8309.34851 BF_2 19.48 0.34 2707 642937984 XP_008199157.1 245 6.9e-18 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54I48 157 4.5e-09 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.34853 BF_2 29.07 0.55 2518 347966510 XP_321327.5 371 1.6e-32 AGAP001756-PA [Anopheles gambiae str. PEST]>gi|333470028|gb|EAA01239.5| AGAP001756-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- A5PK40 286 4.6e-24 Choline transporter-like protein 3 OS=Bos taurus GN=SLC44A3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.34854 BF_2 82.60 0.71 5122 347966510 XP_321327.5 384 9.9e-34 AGAP001756-PA [Anopheles gambiae str. PEST]>gi|333470028|gb|EAA01239.5| AGAP001756-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- Q8N4M1 290 3.2e-24 Choline transporter-like protein 3 OS=Homo sapiens GN=SLC44A3 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.34855 BF_2 356.00 8.52 2035 189237849 XP_974842.2 1185 5.2e-127 PREDICTED: uncharacterized protein LOC663715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.34856 BF_2 3.33 1.56 374 91077314 XP_974673.1 680 3.4e-69 PREDICTED: ADAM 17-like protease isoform X2 [Tribolium castaneum]>gi|270002088|gb|EEZ98535.1| hypothetical protein TcasGA2_TC001039 [Tribolium castaneum] -- -- -- -- -- K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 672 1.2e-69 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF01421//PF00413 Reprolysin (M12B) family zinc metalloprotease//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270//GO:0046872 metalloendopeptidase activity//zinc ion binding//metal ion binding GO:0031012 extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.34858 BF_2 678.95 14.10 2301 91090858 XP_967143.1 1222 3.0e-131 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 912 1.1e-96 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.34859 BF_2 257.00 14.45 1031 260832366 XP_002611128.1 221 1.6e-15 hypothetical protein BRAFLDRAFT_88473 [Branchiostoma floridae]>gi|229296499|gb|EEN67138.1| hypothetical protein BRAFLDRAFT_88473 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P82963 159 1.0e-09 Chaoptin (Fragment) OS=Tribolium castaneum GN=CHP PE=2 SV=1 PF00560//PF00001//PF13855 Leucine Rich Repeat//7 transmembrane receptor (rhodopsin family)//Leucine rich repeat GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.34860 BF_2 81.22 1.34 2820 642928510 XP_008193821.1 2484 1.7e-277 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DN14 1091 2.3e-117 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00606//PF00168 Herpesvirus Glycoprotein B//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.34861 BF_2 84.66 0.98 3900 642923755 XP_008193870.1 936 7.4e-98 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 8.4e-57 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0051726//GO:0051302//GO:0045859 regulation of cell cycle//regulation of cell division//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.34862 BF_2 641.00 19.29 1677 170056139 XP_001863897.1 842 2.5e-87 3,2-trans-enoyl-CoA isomerase, mitochondrial [Culex quinquefasciatus]>gi|167875865|gb|EDS39248.1| 3,2-trans-enoyl-CoA isomerase, mitochondrial [Culex quinquefasciatus] -- -- -- -- -- K13238 DCI 3,2-trans-enoyl-CoA isomerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K13238 P42125 527 3.5e-52 Enoyl-CoA delta isomerase 1, mitochondrial OS=Mus musculus GN=Eci1 PE=1 SV=2 PF01343//PF16113//PF00378 Peptidase family S49//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016836//GO:0003824//GO:0008233 hydro-lyase activity//catalytic activity//peptidase activity -- -- KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.34863 BF_2 285.72 1565.39 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34865 BF_2 3519.21 640.20 517 264667371 ACY71271.1 744 1.8e-76 ribosomal protein S19 [Chrysomela tremula] -- -- -- -- -- K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P39018 541 2.6e-54 40S ribosomal protein S19a OS=Drosophila melanogaster GN=RpS19a PE=1 SV=3 PF01090 Ribosomal protein S19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.34866 BF_2 989.99 67.36 902 264667389 ACY71280.1 925 3.2e-97 ribosomal protein S7 [Chrysomela tremula] 752878389 XM_011258375.1 129 7.74751e-59 PREDICTED: Camponotus floridanus 40S ribosomal protein S7-like (LOC105251512), mRNA K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 Q962S0 854 2.3e-90 40S ribosomal protein S7 OS=Spodoptera frugiperda GN=RpS7 PE=2 SV=1 PF01251 Ribosomal protein S7e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3320 40S ribosomal protein S7 Cluster-8309.34867 BF_2 646.00 18.32 1762 546682654 ERL92566.1 1824 3.6e-201 hypothetical protein D910_09879 [Dendroctonus ponderosae] 674054595 XM_008835479.1 56 5.86509e-18 PREDICTED: Nannospalax galili IK cytokine, down-regulator of HLA II (Ik), mRNA K13109 IK, RED, RER IK cytokine http://www.genome.jp/dbget-bin/www_bget?ko:K13109 Q9Z1M8 738 1.3e-76 Protein Red OS=Mus musculus GN=Ik PE=1 SV=2 PF01496//PF00639//PF07808 V-type ATPase 116kDa subunit family//PPIC-type PPIASE domain//RED-like protein N-terminal region GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0016853//GO:0015078 isomerase activity//hydrogen ion transmembrane transporter activity GO:0033179//GO:0005634 proton-transporting V-type ATPase, V0 domain//nucleus KOG2498 IK cytokine down-regulator of HLA class II Cluster-8309.34868 BF_2 793.39 14.31 2607 642928513 XP_008193822.1 1635 4.4e-179 PREDICTED: uncharacterized protein LOC659984 [Tribolium castaneum] 299884466 FP926002.1 78 5.14661e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51023 606 3.7e-61 ETS-like protein pointed, isoform P2/D OS=Drosophila melanogaster GN=pnt PE=2 SV=2 PF00178//PF00447//PF02198 Ets-domain//HSF-type DNA-binding//Sterile alpha motif (SAM)/Pointed domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.34869 BF_2 551.85 5.60 4408 91080113 XP_967415.1 1588 2.1e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit I [Tribolium castaneum]>gi|270003188|gb|EEZ99635.1| hypothetical protein TcasGA2_TC002391 [Tribolium castaneum] 642918634 XM_962322.2 236 1.28848e-117 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 3 subunit I (LOC655760), mRNA K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1315 3.9e-143 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF04053//PF00400//PF10505//PF10766 Coatomer WD associated region//WD domain, G-beta repeat//NMDA receptor-regulated gene protein 2 C-terminus//Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0006886//GO:0016192//GO:0015893 drug transmembrane transport//intracellular protein transport//vesicle-mediated transport//drug transport GO:0005198//GO:0015238//GO:0005515 structural molecule activity//drug transmembrane transporter activity//protein binding GO:0030117//GO:0008023//GO:0005886 membrane coat//transcription elongation factor complex//plasma membrane KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.34870 BF_2 775.00 391.67 367 91092288 XP_968701.1 166 1.3e-09 PREDICTED: up-regulated during skeletal muscle growth protein 5 [Tribolium castaneum]>gi|270001315|gb|EEZ97762.1| Neb-cGP [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.34872 BF_2 325.00 6.06 2530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34873 BF_2 794.58 7.48 4731 642916721 XP_008192340.1 738 8.2e-75 PREDICTED: coiled-coil domain-containing protein 102A isoform X3 [Tribolium castaneum]>gi|270004300|gb|EFA00748.1| hypothetical protein TcasGA2_TC003630 [Tribolium castaneum] -- -- -- -- -- K16759 CCDC102A coiled-coil domain-containing protein 102A http://www.genome.jp/dbget-bin/www_bget?ko:K16759 Q96A19 384 3.8e-35 Coiled-coil domain-containing protein 102A OS=Homo sapiens GN=CCDC102A PE=1 SV=2 PF16331//PF06009//PF04977//PF06008//PF04508//PF06810//PF00509//PF10174//PF05837//PF07989//PF04799//PF08702//PF04513//PF04871//PF06160//PF11365//PF00769//PF05557//PF07851//PF08287//PF05478//PF04632//PF07058//PF10392//PF13851//PF01920//PF03938//PF07926//PF09728//PF02601//PF11403//PF03233//PF00038//PF04111//PF04048//PF01576//PF06005//PF10473//PF00015//PF04136//PF02050 TolA binding protein trimerisation//Laminin Domain II//Septum formation initiator//Laminin Domain I//Viral A-type inclusion protein repeat//Phage minor structural protein GP20//Haemagglutinin//RIM-binding protein of the cytomatrix active zone//Centromere protein H (CENP-H)//Centrosomin N-terminal motif 1//fzo-like conserved region//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Uso1 / p115 like vesicle tethering protein, C terminal region//Septation ring formation regulator, EzrA//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Mitotic checkpoint protein//TMPIT-like protein//Spc19//Prominin//Fusaric acid resistance protein family//Microtubule-associated protein 70//Golgi transport complex subunit 5//Growth-arrest specific micro-tubule binding//Prefoldin subunit//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein//Myosin-like coiled-coil protein//Exonuclease VII, large subunit//Yeast metallothionein//Aphid transmission protein//Intermediate filament protein//Autophagy protein Apg6//Sec8 exocyst complex component specific domain//Myosin tail//Protein of unknown function (DUF904)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family//Flagellar FliJ protein GO:0008608//GO:0010506//GO:0051382//GO:0030168//GO:0006891//GO:0016032//GO:0019089//GO:0048870//GO:0015031//GO:0007049//GO:0007165//GO:0006810//GO:0007010//GO:0070206//GO:0006886//GO:0006914//GO:0007094//GO:0043093//GO:0000917//GO:0006457//GO:0019064//GO:0006606//GO:0045995//GO:0008053//GO:0006935//GO:0000921//GO:0006904//GO:0071973//GO:0010273//GO:0030334//GO:0071585//GO:0051258//GO:0007155//GO:0030155//GO:0006308 attachment of spindle microtubules to kinetochore//regulation of autophagy//kinetochore assembly//platelet activation//intra-Golgi vesicle-mediated transport//viral process//transmission of virus//cell motility//protein transport//cell cycle//signal transduction//transport//cytoskeleton organization//protein trimerization//intracellular protein transport//autophagy//mitotic spindle assembly checkpoint//FtsZ-dependent cytokinesis//barrier septum assembly//protein folding//fusion of virus membrane with host plasma membrane//protein import into nucleus//regulation of embryonic development//mitochondrial fusion//chemotaxis//septin ring assembly//vesicle docking involved in exocytosis//bacterial-type flagellum-dependent cell motility//detoxification of copper ion//regulation of cell migration//detoxification of cadmium ion//protein polymerization//cell adhesion//regulation of cell adhesion//DNA catabolic process GO:0005102//GO:0051082//GO:0046870//GO:0045502//GO:0003924//GO:0003774//GO:0030674//GO:0019905//GO:0008565//GO:0008017//GO:0042803//GO:0008134//GO:0008092//GO:0005198//GO:0004871//GO:0046789//GO:0005507//GO:0008855 receptor binding//unfolded protein binding//cadmium ion binding//dynein binding//GTPase activity//motor activity//protein binding, bridging//syntaxin binding//protein transporter activity//microtubule binding//protein homodimerization activity//transcription factor binding//cytoskeletal protein binding//structural molecule activity//signal transducer activity//host cell surface receptor binding//copper ion binding//exodeoxyribonuclease VII activity GO:0009288//GO:0016272//GO:0005615//GO:0019028//GO:0045298//GO:0000776//GO:0005667//GO:0005801//GO:0031514//GO:0016020//GO:0017119//GO:0005741//GO:0005886//GO:0009318//GO:0048786//GO:0005577//GO:0019898//GO:0005882//GO:0009986//GO:0030286//GO:0042729//GO:0005737//GO:0005876//GO:0016459//GO:0016021//GO:0005815//GO:0005940//GO:0000145//GO:0019031 bacterial-type flagellum//prefoldin complex//extracellular space//viral capsid//tubulin complex//kinetochore//transcription factor complex//cis-Golgi network//motile cilium//membrane//Golgi transport complex//mitochondrial outer membrane//plasma membrane//exodeoxyribonuclease VII complex//presynaptic active zone//fibrinogen complex//extrinsic component of membrane//intermediate filament//cell surface//dynein complex//DASH complex//cytoplasm//spindle microtubule//myosin complex//integral component of membrane//microtubule organizing center//septin ring//exocyst//viral envelope -- -- Cluster-8309.34875 BF_2 6.29 0.41 929 -- -- -- -- -- 642913269 XM_008203242.1 84 8.27614e-34 PREDICTED: Tribolium castaneum troponin T, skeletal muscle (LOC663893), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34876 BF_2 289.04 2.55 5020 642914078 XP_969963.3 2013 1.2e-222 PREDICTED: uncharacterized protein LOC658486 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15898//PF17078//PF05529//PF15177 cGMP-dependent protein kinase interacting domain//SWI5-dependent HO expression protein 3//B-cell receptor-associated protein 31-like//Interleukin-28A GO:0051028//GO:0051607//GO:0050778//GO:0006886//GO:0048309//GO:0007165//GO:0007259 mRNA transport//defense response to virus//positive regulation of immune response//intracellular protein transport//endoplasmic reticulum inheritance//signal transduction//JAK-STAT cascade GO:0019901//GO:0005125 protein kinase binding//cytokine activity GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane -- -- Cluster-8309.34878 BF_2 1001.51 12.66 3596 571568658 XP_006565113.1 324 6.3e-27 PREDICTED: optineurin isoform X2 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88522 179 1.7e-11 NF-kappa-B essential modulator OS=Mus musculus GN=Ikbkg PE=1 SV=2 PF08287//PF06160//PF07651//PF10186//PF13851//PF02183 Spc19//Septation ring formation regulator, EzrA//ANTH domain//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding//Homeobox associated leucine zipper GO:0008608//GO:0006355//GO:0010508//GO:0048870//GO:0000921 attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated//positive regulation of autophagy//cell motility//septin ring assembly GO:0043565//GO:0003700//GO:0005543 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//phospholipid binding GO:0042729//GO:0005876//GO:0016021//GO:0031514//GO:0005667//GO:0005940 DASH complex//spindle microtubule//integral component of membrane//motile cilium//transcription factor complex//septin ring -- -- Cluster-8309.34880 BF_2 987.21 29.82 1672 332373138 AEE61710.1 1814 4.9e-200 unknown [Dendroctonus ponderosae] 374719504 JN671475.1 117 6.84413e-52 Buccinum sp. JV-2012 catalase (cat) gene, partial cds K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P04040 1494 2.6e-164 Catalase OS=Homo sapiens GN=CAT PE=1 SV=3 PF00199 Catalase GO:0006568//GO:0015947//GO:0006979//GO:0055114//GO:0006804 tryptophan metabolic process//methane metabolic process//response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction GO:0004096//GO:0020037 catalase activity//heme binding -- -- KOG0047 Catalase Cluster-8309.34882 BF_2 2015.73 30.19 3080 385845164 AFI81409.1 1440 2.1e-156 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 57 2.87339e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 586 9.2e-59 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF03099//PF08127 Biotin/lipoate A/B protein ligase family//Peptidase family C1 propeptide GO:0006508//GO:0006464//GO:0050790 proteolysis//cellular protein modification process//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.34884 BF_2 86.89 1.47 2761 281345976 EFB21560.1 509 1.7e-48 hypothetical protein PANDA_020762 [Ailuropoda melanoleuca] -- -- -- -- -- -- -- -- -- Q6ZMW2 488 1.9e-47 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF04810//PF01363//PF02776//PF13912//PF01428//PF01844//PF02072//PF10503//PF06467//PF00130//PF01155//PF00412//PF02892//PF16622//PF05191//PF13465 Zinc finger, C2H2 type//Sec23/Sec24 zinc finger//FYVE zinc finger//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//C2H2-type zinc finger//AN1-like Zinc finger//HNH endonuclease//Prepro-orexin//Esterase PHB depolymerase//MYM-type Zinc finger with FCS sequence motif//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//LIM domain//BED zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc-finger double domain GO:0006464//GO:0007631//GO:0046034//GO:0006886//GO:0035556//GO:0006144//GO:0006888//GO:0007218 cellular protein modification process//feeding behavior//ATP metabolic process//intracellular protein transport//intracellular signal transduction//purine nucleobase metabolic process//ER to Golgi vesicle-mediated transport//neuropeptide signaling pathway GO:0008270//GO:0004017//GO:0004519//GO:0003677//GO:0016151//GO:0003676//GO:0046872//GO:0030976 zinc ion binding//adenylate kinase activity//endonuclease activity//DNA binding//nickel cation binding//nucleic acid binding//metal ion binding//thiamine pyrophosphate binding GO:0030127//GO:0005576 COPII vesicle coat//extracellular region -- -- Cluster-8309.34885 BF_2 291.00 14.53 1125 -- -- -- -- -- 49659416 AB087746.1 211 2.5405e-104 Ixodes uriae mitochondrial DNA, complete genome, isolate:ag5 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34886 BF_2 3.00 0.76 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34887 BF_2 531.77 2.70 8530 91088973 XP_966480.1 3207 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 642932569 XM_961387.2 842 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 1 (LOC654946), mRNA K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2867 0.0e+00 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0016310//GO:0006468//GO:0009069//GO:0038032 phosphorylation//protein phosphorylation//serine family amino acid metabolic process//termination of G-protein coupled receptor signaling pathway GO:0004672//GO:0004703//GO:0016773//GO:0005524 protein kinase activity//G-protein coupled receptor kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.34889 BF_2 33.00 0.52 2939 270015239 EFA11687.1 612 2.1e-60 hypothetical protein TcasGA2_TC008551 [Tribolium castaneum] -- -- -- -- -- K16804 DLGAP5, DLG7 disks large-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16804 Q7K3L1 284 9.2e-24 Guanylate kinase-associated protein mars OS=Drosophila melanogaster GN=mars PE=1 SV=1 PF03359 Guanylate-kinase-associated protein (GKAP) protein GO:0023052 signaling -- -- -- -- -- -- Cluster-8309.34890 BF_2 44.75 1.74 1361 -- -- -- -- -- 99029204 DQ515965.1 46 1.63116e-12 Leptinotarsa decemlineata putative glycine-rich protein (GRP1) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34891 BF_2 1416.00 176.36 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34892 BF_2 197.16 3.65 2549 642929562 XP_008195885.1 3634 0.0e+00 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] -- -- -- -- -- K11967 ANKIB1 ankyrin repeat and IBR domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11967 Q6ZPS6 1901 2.5e-211 Ankyrin repeat and IBR domain-containing protein 1 OS=Mus musculus GN=Ankib1 PE=1 SV=2 PF00097//PF00023//PF14634//PF13606//PF13639 Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//zinc-RING finger domain//Ankyrin repeat//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG1815 Predicted E3 ubiquitin ligase Cluster-8309.34894 BF_2 55.00 12.57 470 -- -- -- -- -- 56968035 AY859581.1 206 6.12627e-102 Homarus americanus internal transcribed spacer 2 and 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34896 BF_2 389.73 5.28 3376 270006170 EFA02618.1 2777 2.6e-311 hypothetical protein TcasGA2_TC008338 [Tribolium castaneum] -- -- -- -- -- K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 A8Y236 1566 2.3e-172 Putative polypeptide N-acetylgalactosaminyltransferase 10 OS=Caenorhabditis briggsae GN=gly-10 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.34898 BF_2 821.85 7.30 4994 478252696 ENN73092.1 2419 1.0e-269 hypothetical protein YQE_10296, partial [Dendroctonus ponderosae] -- -- -- -- -- K04681 RBL1 retinoblastoma-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04681 Q64701 1034 1.7e-110 Retinoblastoma-like protein 1 OS=Mus musculus GN=Rbl1 PE=1 SV=3 PF01857//PF01858 Retinoblastoma-associated protein B domain//Retinoblastoma-associated protein A domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus KOG1010 Rb (Retinoblastoma tumor suppressor)-related protein Cluster-8309.3490 BF_2 3.00 0.38 616 270010586 EFA07034.1 434 1.9e-40 hypothetical protein TcasGA2_TC010006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34900 BF_2 607.44 3.45 7654 642912355 XP_008199607.1 1480 1.2e-160 PREDICTED: PHD and RING finger domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270002669|gb|EEZ99116.1| hypothetical protein TcasGA2_TC005009 [Tribolium castaneum] -- -- -- -- -- K17586 PHRF1 PHD and RING finger domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17586 Q9P1Y6 556 6.9e-55 PHD and RING finger domain-containing protein 1 OS=Homo sapiens GN=PHRF1 PE=1 SV=3 PF13639//PF13994//PF12861//PF00130//PF00628//PF14634//PF12678//PF00097 Ring finger domain//PgaD-like protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0042710//GO:0035556 protein ubiquitination//biofilm formation//intracellular signal transduction GO:0005515//GO:0004842//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0825 PHD Zn-finger protein Cluster-8309.34901 BF_2 2892.59 31.72 4102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03893 Lipase 3 N-terminal region GO:0016042 lipid catabolic process -- -- -- -- -- -- Cluster-8309.34902 BF_2 175.40 2.86 2855 642925940 XP_008194704.1 1419 5.3e-154 PREDICTED: alpha-1D adrenergic receptor [Tribolium castaneum]>gi|270009238|gb|EFA05686.1| hypothetical protein TcasGA2_TC015120 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TTM9 138 7.6e-07 Alpha-1D adrenergic receptor OS=Sus scrofa GN=ADRA1D PE=3 SV=1 PF08099//PF00001 Scorpion calcine family//7 transmembrane receptor (rhodopsin family) GO:0009405//GO:0007186//GO:0006810 pathogenesis//G-protein coupled receptor signaling pathway//transport GO:0004930//GO:0019855 G-protein coupled receptor activity//calcium channel inhibitor activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.34904 BF_2 868.00 15.40 2645 189240338 XP_970612.2 996 5.5e-105 PREDICTED: probable phosphomannomutase [Tribolium castaneum] -- -- -- -- -- K17497 PMM phosphomannomutase http://www.genome.jp/dbget-bin/www_bget?ko:K17497 Q9VTZ6 770 3.7e-80 Probable phosphomannomutase OS=Drosophila melanogaster GN=CG10688 PE=2 SV=1 PF03332//PF16113//PF00378//PF01972 Eukaryotic phosphomannomutase//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//Serine dehydrogenase proteinase GO:0006000//GO:0006013//GO:0009298//GO:0008152 fructose metabolic process//mannose metabolic process//GDP-mannose biosynthetic process//metabolic process GO:0004615//GO:0016836//GO:0003824 phosphomannomutase activity//hydro-lyase activity//catalytic activity GO:0005737//GO:0016021 cytoplasm//integral component of membrane KOG3189 Phosphomannomutase Cluster-8309.34905 BF_2 854.23 5.74 6512 546679248 ERL89742.1 2986 0.0e+00 hypothetical protein D910_07103 [Dendroctonus ponderosae] 641702319 XM_008141598.1 150 1.22359e-69 PREDICTED: Eptesicus fuscus ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant X3, mRNA K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 2217 1.5e-247 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 PF15499//PF00917//PF00443 Ubiquitin-specific peptidase-like, SUMO isopeptidase//MATH domain//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0032183//GO:0070140//GO:0005515 ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.34907 BF_2 402.00 10.71 1857 478250085 ENN70591.1 1469 5.5e-160 hypothetical protein YQE_12766, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 322 2.3e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856//PF11744 SET domain//Aluminium activated malate transporter GO:0015743 malate transport GO:0005515 protein binding -- -- -- -- Cluster-8309.34909 BF_2 765.98 37.93 1132 91095123 XP_970890.1 587 6.3e-58 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 397 2.8e-37 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF16794//PF00106 Fibronectin-III type domain//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- -- -- Cluster-8309.34911 BF_2 81.26 4.40 1059 91089683 XP_974633.1 496 2.1e-47 PREDICTED: survival of motor neuron-related-splicing factor 30 [Tribolium castaneum]>gi|270011328|gb|EFA07776.1| hypothetical protein TcasGA2_TC005331 [Tribolium castaneum] -- -- -- -- -- K12839 SMNDC1, SPF30 survival of motor neuron-related-splicing factor 30 http://www.genome.jp/dbget-bin/www_bget?ko:K12839 Q7ZV80 162 4.6e-10 Survival of motor neuron-related-splicing factor 30 OS=Danio rerio GN=smndc1 PE=2 SV=1 PF06003//PF03039//PF02294 Survival motor neuron protein (SMN)//Interleukin-12 alpha subunit//7kD DNA-binding domain GO:0006955//GO:0051252//GO:0040007//GO:0007165//GO:0006397//GO:0008283 immune response//regulation of RNA metabolic process//growth//signal transduction//mRNA processing//cell proliferation GO:0005143//GO:0003723//GO:0008083//GO:0003677//GO:0004521 interleukin-12 receptor binding//RNA binding//growth factor activity//DNA binding//endoribonuclease activity GO:0005576//GO:0005737//GO:0005634//GO:0042022 extracellular region//cytoplasm//nucleus//interleukin-12 receptor complex -- -- Cluster-8309.34914 BF_2 22.11 0.42 2477 642916810 XP_967695.2 1465 2.1e-159 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 981 1.2e-104 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0042301//GO:0005515 phosphate ion binding//protein binding GO:0016020//GO:0009523 membrane//photosystem II KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.34916 BF_2 112.66 5.01 1228 642910461 XP_008190748.1 505 2.2e-48 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 298 9.1e-26 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.34918 BF_2 25.00 0.62 1971 693585420 AIS39468.1 2582 5.1e-289 heat shock 70 kDa protein [Haemaphysalis flava] 241153674 XM_002407088.1 603 0 Ixodes scapularis heat shock protein, putative, mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2518 5.5e-283 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF14630//PF01968//PF02782//PF06723//PF01702 Origin recognition complex (ORC) subunit 5 C-terminus//Hydantoinase/oxoprolinase//FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein//Queuine tRNA-ribosyltransferase GO:0008616//GO:0000902//GO:0006260//GO:0005975//GO:0006400 queuosine biosynthetic process//cell morphogenesis//DNA replication//carbohydrate metabolic process//tRNA modification GO:0016787//GO:0008479//GO:0016773 hydrolase activity//queuine tRNA-ribosyltransferase activity//phosphotransferase activity, alcohol group as acceptor GO:0005634//GO:0000808 nucleus//origin recognition complex KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.34919 BF_2 224.50 11.94 1074 91077504 XP_966852.1 517 7.8e-50 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 O13035 298 8.0e-26 Proactivator polypeptide OS=Gallus gallus GN=PSAP PE=1 SV=1 PF05184 Saposin-like type B, region 1 GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.34920 BF_2 2561.36 21.72 5220 91092978 XP_967458.1 1021 1.4e-107 PREDICTED: type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase [Tribolium castaneum]>gi|270004800|gb|EFA01248.1| hypothetical protein TcasGA2_TC002125 [Tribolium castaneum] 827558552 XM_012694950.1 58 1.36056e-18 PREDICTED: Bombyx mori TPPP family protein CG45057-like (LOC101741645), transcript variant X2, mRNA K13084 TMEM55 phosphatidylinositol-4,5-bisphosphate 4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K13084 Q4R6W2 542 2.0e-53 Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase OS=Macaca fascicularis GN=TMEM55B PE=2 SV=1 PF09788//PF13903//PF02892 Transmembrane protein 55A//PMP-22/EMP/MP20/Claudin tight junction//BED zinc finger GO:0046856 phosphatidylinositol dephosphorylation GO:0003677//GO:0034597 DNA binding//phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity GO:0016021 integral component of membrane KOG4684 Uncharacterized conserved protein, contains C4-type Zn-finger Cluster-8309.34923 BF_2 15505.00 2403.09 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34924 BF_2 13.00 2.19 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34925 BF_2 3841.36 228.96 989 91092672 XP_971117.1 1205 1.2e-129 PREDICTED: phosphoglycerate mutase 1 [Tribolium castaneum]>gi|270014862|gb|EFA11310.1| hypothetical protein TcasGA2_TC010847 [Tribolium castaneum] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 Q3SZ62 915 2.1e-97 Phosphoglycerate mutase 1 OS=Bos taurus GN=PGAM1 PE=2 SV=3 -- -- GO:0006094//GO:0006096 gluconeogenesis//glycolytic process GO:0004619 phosphoglycerate mutase activity -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.34926 BF_2 1637.00 721.71 380 557007445 XP_006005038.1 484 1.9e-46 PREDICTED: ubiquitin-60S ribosomal protein L40-like [Latimeria chalumnae] 462366006 APGK01027402.1 124 1.86463e-56 Dendroctonus ponderosae Seq01027412, whole genome shotgun sequence K02927 RP-L40e, RPL40 large subunit ribosomal protein L40e http://www.genome.jp/dbget-bin/www_bget?ko:K02927 P0CH06 474 1.1e-46 Ubiquitin-60S ribosomal protein L40 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ubi1 PE=1 SV=1 PF00240//PF01020 Ubiquitin family//Ribosomal L40e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840 ribosome KOG0003 Ubiquitin/60s ribosomal protein L40 fusion Cluster-8309.34927 BF_2 12.00 4.09 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34928 BF_2 882.70 13.36 3051 642913496 XP_008201037.1 1087 1.8e-115 PREDICTED: uncharacterized protein LOC100142275 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34931 BF_2 4552.25 137.21 1675 -- -- -- -- -- 99029204 DQ515965.1 46 2.01742e-12 Leptinotarsa decemlineata putative glycine-rich protein (GRP1) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34932 BF_2 502.12 35.73 875 270011202 EFA07650.1 694 1.9e-70 hypothetical protein TcasGA2_TC030561 [Tribolium castaneum] -- -- -- -- -- K10428 DCTN6 dynactin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K10428 Q5R7D8 443 1.0e-42 Dynactin subunit 6 OS=Pongo abelii GN=DCTN6 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772 transferase activity, transferring phosphorus-containing groups -- -- KOG4042 Dynactin subunit p27/WS-3, involved in transport of organelles along microtubules Cluster-8309.34933 BF_2 180.86 3.05 2771 642924584 XP_008194352.1 3907 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 8 isoform X2 [Tribolium castaneum] 462337280 APGK01037611.1 80 4.22938e-31 Dendroctonus ponderosae Seq01037621, whole genome shotgun sequence -- -- -- -- P60882 1400 3.4e-153 Multiple epidermal growth factor-like domains protein 8 OS=Mus musculus GN=Megf8 PE=2 SV=2 PF01437//PF01344//PF07645//PF07646 Plexin repeat//Kelch motif//Calcium-binding EGF domain//Kelch motif -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.34934 BF_2 96.00 8.13 781 642913522 XP_008201049.1 522 1.5e-50 PREDICTED: venom allergen 3-like [Tribolium castaneum]>gi|270001720|gb|EEZ98167.1| hypothetical protein TcasGA2_TC000596 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- W4VS53 269 1.3e-22 CRISP/Allergen/PR-1 OS=Trittame loki PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3017 Defense-related protein containing SCP domain Cluster-8309.34935 BF_2 13.00 2.14 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34936 BF_2 523.00 11.89 2127 189233693 XP_969378.2 1908 7.9e-211 PREDICTED: sorting nexin-17 [Tribolium castaneum]>gi|642910711|ref|XP_008200527.1| PREDICTED: sorting nexin-17 [Tribolium castaneum] -- -- -- -- -- K17929 SNX17 sorting nexin-17 http://www.genome.jp/dbget-bin/www_bget?ko:K17929 Q5RID7 1024 1.0e-109 Sorting nexin-17 OS=Danio rerio GN=snx17 PE=2 SV=1 PF00787//PF04574 PX domain//Protein of unknown function (DUF592) GO:0006355//GO:0006807//GO:0006476//GO:0006342 regulation of transcription, DNA-templated//nitrogen compound metabolic process//protein deacetylation//chromatin silencing GO:0008270//GO:0016811//GO:0035091//GO:0017136//GO:0051287 zinc ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//phosphatidylinositol binding//NAD-dependent histone deacetylase activity//NAD binding GO:0000118 histone deacetylase complex KOG3784 Sorting nexin protein SNX27 Cluster-8309.34937 BF_2 25.07 0.50 2369 270008370 EFA04818.1 1154 2.4e-123 hypothetical protein TcasGA2_TC014868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SWR8 600 1.7e-60 Ataxin-2 homolog OS=Drosophila melanogaster GN=Atx2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2375 Protein interacting with poly(A)-binding protein Cluster-8309.34938 BF_2 1255.99 14.23 3979 270012994 EFA09442.1 3262 0.0e+00 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61824 1131 7.6e-122 Disintegrin and metalloproteinase domain-containing protein 12 OS=Mus musculus GN=Adam12 PE=1 SV=2 PF01562//PF06701//PF10462//PF00413//PF07998//PF08516//PF01421 Reprolysin family propeptide//Mib_herc2//Peptidase M66//Matrixin//Peptidase family M54//ADAM cysteine-rich//Reprolysin (M12B) family zinc metalloprotease GO:0016567//GO:0006508 protein ubiquitination//proteolysis GO:0004842//GO:0046872//GO:0008270//GO:0004222 ubiquitin-protein transferase activity//metal ion binding//zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family Cluster-8309.34941 BF_2 4170.09 48.92 3853 642934754 XP_967096.2 1811 2.5e-199 PREDICTED: sorting nexin-30 [Tribolium castaneum] 642934008 XM_008199379.1 181 4.22135e-87 PREDICTED: Tribolium castaneum interferon-related developmental regulator 2 (LOC662460), mRNA K17921 SNX7_30 sorting nexin-7/30 http://www.genome.jp/dbget-bin/www_bget?ko:K17921 Q12894 597 6.1e-60 Interferon-related developmental regulator 2 OS=Homo sapiens GN=IFRD2 PE=1 SV=3 PF03114//PF02985//PF00787 BAR domain//HEAT repeat//PX domain -- -- GO:0035091//GO:0005515 phosphatidylinositol binding//protein binding GO:0005737 cytoplasm KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.34942 BF_2 2833.55 55.73 2414 332374254 AEE62268.1 1568 2.4e-171 unknown [Dendroctonus ponderosae]>gi|546686166|gb|ERL95552.1| hypothetical protein D910_12813 [Dendroctonus ponderosae] -- -- -- -- -- K09507 DNAJB1 DnaJ homolog subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09507 Q24133 1004 2.4e-107 DnaJ protein homolog 1 OS=Drosophila melanogaster GN=DnaJ-1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.34946 BF_2 310.82 0.71 18570 612342210 AHW99830.1 23489 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1528 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 19793 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00622//PF00520//PF01365//PF00487//PF06423//PF06459//PF02815 SPRY domain//Ion transport protein//RIH domain//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//MIR domain GO:0006874//GO:0070588//GO:0006816//GO:0055085//GO:0006811//GO:0006506//GO:0006629 cellular calcium ion homeostasis//calcium ion transmembrane transport//calcium ion transport//transmembrane transport//ion transport//GPI anchor biosynthetic process//lipid metabolic process GO:0005216//GO:0005515//GO:0005219//GO:0016746//GO:0005262 ion channel activity//protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium channel activity GO:0005622//GO:0016021//GO:0016020//GO:0005789 intracellular//integral component of membrane//membrane//endoplasmic reticulum membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.34949 BF_2 314.00 5.09 2868 642926986 XP_008195091.1 2065 6.6e-229 PREDICTED: probable ATP-dependent RNA helicase DDX27 [Tribolium castaneum]>gi|270010045|gb|EFA06493.1| hypothetical protein TcasGA2_TC009390 [Tribolium castaneum] -- -- -- -- -- K13181 DDX27, DRS1 ATP-dependent RNA helicase DDX27 http://www.genome.jp/dbget-bin/www_bget?ko:K13181 A1A4H6 1365 4.0e-149 Probable ATP-dependent RNA helicase DDX27 OS=Bos taurus GN=DDX27 PE=2 SV=1 PF00270//PF02068//PF01459 DEAD/DEAH box helicase//Plant PEC family metallothionein//Eukaryotic porin GO:0055085 transmembrane transport GO:0005524//GO:0008270//GO:0000166//GO:0004386//GO:0003676 ATP binding//zinc ion binding//nucleotide binding//helicase activity//nucleic acid binding GO:0005741 mitochondrial outer membrane KOG0338 ATP-dependent RNA helicase Cluster-8309.34950 BF_2 3870.10 51.35 3440 642911103 XP_008200578.1 2635 6.4e-295 PREDICTED: twitchin isoform X6 [Tribolium castaneum] 642911108 XM_008202360.1 709 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X9, mRNA -- -- -- -- Q23551 419 2.4e-39 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF13895//PF02480 Immunoglobulin domain//Alphaherpesvirus glycoprotein E -- -- GO:0005515 protein binding GO:0016020 membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.34951 BF_2 376.91 3.93 4303 642911095 XP_008200574.1 2030 1.1e-224 PREDICTED: twitchin isoform X2 [Tribolium castaneum] 642911110 XM_008202361.1 549 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- O01761 403 2.1e-37 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF02480//PF13895 Alphaherpesvirus glycoprotein E//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.34956 BF_2 924.00 27.34 1701 270010395 EFA06843.1 2157 8.4e-240 hypothetical protein TcasGA2_TC009786 [Tribolium castaneum] 752877329 XM_011257793.1 256 3.74343e-129 PREDICTED: Camponotus floridanus serine--tRNA ligase, cytoplasmic (LOC105251197), mRNA K01875 SARS, serS seryl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01875 P26638 1727 2.5e-191 Serine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Sars PE=2 SV=3 PF00587 tRNA synthetase class II core domain (G, H, P, S and T) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding -- -- KOG2509 Seryl-tRNA synthetase Cluster-8309.34958 BF_2 299.97 7.80 1896 91083955 XP_975011.1 1667 6.2e-183 PREDICTED: prolactin regulatory element-binding protein isoform X1 [Tribolium castaneum]>gi|270007977|gb|EFA04425.1| hypothetical protein TcasGA2_TC014725 [Tribolium castaneum] -- -- -- -- -- K14003 PREB, SEC12 prolactin regulatory element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14003 Q9HCU5 487 1.7e-47 Prolactin regulatory element-binding protein OS=Homo sapiens GN=PREB PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p Cluster-8309.34963 BF_2 5243.58 44.68 5197 642932227 XP_008194631.1 501 2.7e-47 PREDICTED: transforming growth factor beta-1-induced transcript 1 protein-like isoform X4 [Tribolium castaneum] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 247 3.2e-19 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01853//PF01258//PF00412 MOZ/SAS family//Prokaryotic dksA/traR C4-type zinc finger//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0016747//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.34966 BF_2 40.87 0.43 4293 270016407 EFA12853.1 2602 5.3e-291 hypothetical protein TcasGA2_TC000150 [Tribolium castaneum] -- -- -- -- -- K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 O76083 900 5.0e-95 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Homo sapiens GN=PDE9A PE=1 SV=1 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.34969 BF_2 7.00 0.34 1147 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34971 BF_2 297.00 14.72 1131 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34972 BF_2 5456.22 144.84 1863 568599616 AHE13803.1 391 5.5e-35 chemosensory protein 8 [Lissorhoptrus oryzophilus] 329762923 HQ587041.1 381 0 Batocera horsfieldi chemosensory protein (CSP2) mRNA, complete cds -- -- -- -- Q9W1C9 295 3.1e-25 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF00660 Seripauperin and TIP1 family GO:0006950 response to stress -- -- -- -- -- -- Cluster-8309.34973 BF_2 61.00 1.57 1915 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34976 BF_2 22.00 1.92 767 817061123 XP_012252151.1 183 3.0e-11 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.34980 BF_2 764.83 11.34 3108 91082745 XP_973149.1 1238 5.6e-133 PREDICTED: soluble NSF attachment protein [Tribolium castaneum]>gi|270014950|gb|EFA11398.1| hypothetical protein TcasGA2_TC013571 [Tribolium castaneum] -- -- -- -- -- K15296 NAPA, SNAPA, SEC17 alpha-soluble NSF attachment protein http://www.genome.jp/dbget-bin/www_bget?ko:K15296 Q23983 1032 1.8e-110 Soluble NSF attachment protein OS=Drosophila melanogaster GN=Snap PE=1 SV=1 PF13176//PF09204//PF13414//PF13174//PF13181//PF00515//PF02609 Tetratricopeptide repeat//Bacterial self-protective colicin-like immunity//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Exonuclease VII small subunit GO:0006308//GO:0006955//GO:0030153//GO:0006886 DNA catabolic process//immune response//bacteriocin immunity//intracellular protein transport GO:0015643//GO:0008855//GO:0005515 toxic substance binding//exodeoxyribonuclease VII activity//protein binding GO:0009318//GO:0005622//GO:0019814 exodeoxyribonuclease VII complex//intracellular//immunoglobulin complex KOG1586 Protein required for fusion of vesicles in vesicular transport, alpha-SNAP Cluster-8309.34981 BF_2 3444.00 158.17 1198 -- -- -- -- -- 462332881 APGK01039173.1 34 6.7034e-06 Dendroctonus ponderosae Seq01039183, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34983 BF_2 38.85 0.89 2120 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34985 BF_2 437.00 39.50 750 91082035 XP_970659.1 811 4.4e-84 PREDICTED: transmembrane and coiled-coil domain-containing protein 1 [Tribolium castaneum]>gi|270007385|gb|EFA03833.1| hypothetical protein TcasGA2_TC013949 [Tribolium castaneum] 805816325 XM_003706745.2 194 4.7017e-95 PREDICTED: Megachile rotundata transmembrane and coiled-coil domain-containing protein 1 (LOC100881658), mRNA -- -- -- -- Q3T0N3 623 1.2e-63 Transmembrane and coiled-coil domain-containing protein 1 OS=Bos taurus GN=TMCO1 PE=2 SV=1 PF01733//PF02601//PF01956//PF00558//PF02096 Nucleoside transporter//Exonuclease VII, large subunit//Integral membrane protein DUF106//Vpu protein//60Kd inner membrane protein GO:0015858//GO:0051205//GO:0019076//GO:0006810//GO:0006812//GO:0006308//GO:0032801 nucleoside transport//protein insertion into membrane//viral release from host cell//transport//cation transport//DNA catabolic process//receptor catabolic process GO:0005261//GO:0008855//GO:0005337 cation channel activity//exodeoxyribonuclease VII activity//nucleoside transmembrane transporter activity GO:0016021//GO:0009318//GO:0016020//GO:0033644 integral component of membrane//exodeoxyribonuclease VII complex//membrane//host cell membrane KOG3312 Predicted membrane protein Cluster-8309.34986 BF_2 6803.29 365.88 1065 769865040 XP_011644434.1 1793 8.5e-198 PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus]>gi|769865042|ref|XP_011644435.1| PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus]>gi|769865044|ref|XP_011644436.1| PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus]>gi|769865046|ref|XP_011644437.1| PREDICTED: elongation factor 1-alpha [Pogonomyrmex barbatus] 410810328 HE962191.1 501 0 Phaedon cochleariae mRNA for elongation factor 1 alpha (ef1alpha gene) K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P05303 1772 9.5e-197 Elongation factor 1-alpha 2 OS=Drosophila melanogaster GN=Ef1alpha100E PE=2 SV=2 PF04670//PF01926//PF03144 Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.34987 BF_2 23.00 3.00 608 328899696 AEB54645.1 674 2.8e-68 ribosomal protein L9 [Procambarus clarkii] 262401370 FJ774867.1 286 2.71478e-146 Scylla paramamosain RPL9 protein-like protein mRNA, partial cds K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 P50882 537 8.7e-54 60S ribosomal protein L9 OS=Drosophila melanogaster GN=RpL9 PE=1 SV=2 PF00347//PF15510 Ribosomal protein L6//Centromere kinetochore component W GO:0006412//GO:0051382//GO:0042254//GO:0007067 translation//kinetochore assembly//ribosome biogenesis//mitotic nuclear division GO:0003677//GO:0019843//GO:0003735 DNA binding//rRNA binding//structural constituent of ribosome GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-8309.3499 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.34991 BF_2 587.45 14.73 1956 642933488 XP_008197439.1 1259 1.3e-135 PREDICTED: solute carrier family 25 member 38-A isoform X1 [Tribolium castaneum] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q08CI8 776 5.4e-81 Solute carrier family 25 member 38-A OS=Danio rerio GN=slc25a38a PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0766 Predicted mitochondrial carrier protein Cluster-8309.34993 BF_2 8572.04 733.55 776 91080583 XP_973590.1 661 1.1e-66 PREDICTED: 60S ribosomal protein L27a [Tribolium castaneum]>gi|270005809|gb|EFA02257.1| hypothetical protein TcasGA2_TC007920 [Tribolium castaneum] 70909818 AM049096.1 177 1.37402e-85 Agriotes lineatus mRNA for ribosomal protein L27Ae (rpL27Ae gene) K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 Q27021 563 1.1e-56 60S ribosomal protein L27a OS=Tenebrio molitor GN=RpL27A PE=2 SV=1 -- -- GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1742 60s ribosomal protein L15/L27 Cluster-8309.34994 BF_2 86.24 1.54 2630 642921394 XP_008192849.1 1690 1.8e-185 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270006281|gb|EFA02729.1| hypothetical protein TcasGA2_TC008454 [Tribolium castaneum] -- -- -- -- -- K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 P45844 984 5.6e-105 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF01061 ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.34995 BF_2 526.00 16.37 1631 478254720 ENN74961.1 2325 2.7e-259 hypothetical protein YQE_08537, partial [Dendroctonus ponderosae]>gi|546682080|gb|ERL92066.1| hypothetical protein D910_09388 [Dendroctonus ponderosae] -- -- -- -- -- K10599 PRPF19, PRP19 pre-mRNA-processing factor 19 http://www.genome.jp/dbget-bin/www_bget?ko:K10599 Q9UMS4 1726 3.1e-191 Pre-mRNA-processing factor 19 OS=Homo sapiens GN=PRPF19 PE=1 SV=1 PF00400//PF04564//PF11716//PF11789 WD domain, G-beta repeat//U-box domain//Mycothiol maleylpyruvate isomerase N-terminal domain//Zinc-finger of the MIZ type in Nse subunit GO:0016567 protein ubiquitination GO:0005515//GO:0046872//GO:0004842//GO:0008270 protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding -- -- KOG0289 mRNA splicing factor Cluster-8309.34997 BF_2 5.97 0.38 951 571541676 XP_003249242.2 265 1.2e-20 PREDICTED: uncharacterized protein LOC100576326 [Apis mellifera] -- -- -- -- -- -- -- -- -- Q9BYE2 138 2.5e-07 Transmembrane protease serine 13 OS=Homo sapiens GN=TMPRSS13 PE=2 SV=4 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.34998 BF_2 662.61 22.56 1516 642912278 XP_967486.2 591 2.9e-58 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] 224922973 AC235209.1 34 8.53631e-06 Glycine max strain Williams 82 clone GM_WBb0018O23, complete sequence K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98164 194 1.3e-13 Low-density lipoprotein receptor-related protein 2 OS=Homo sapiens GN=LRP2 PE=1 SV=3 PF00089//PF05460//PF00057 Trypsin//Origin recognition complex subunit 6 (ORC6)//Low-density lipoprotein receptor domain class A GO:0006260//GO:0006508 DNA replication//proteolysis GO:0003677//GO:0004252//GO:0005515 DNA binding//serine-type endopeptidase activity//protein binding GO:0005664 nuclear origin of replication recognition complex -- -- Cluster-8309.34999 BF_2 2207.20 22.93 4314 270002885 EEZ99332.1 703 8.5e-71 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75096 311 1.0e-26 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF03875//PF00057//PF07415//PF00089 Statherin//Low-density lipoprotein receptor domain class A//Gammaherpesvirus latent membrane protein (LMP2) protein//Trypsin GO:0030500//GO:0042742//GO:0006508//GO:0019042 regulation of bone mineralization//defense response to bacterium//proteolysis//viral latency GO:0005515//GO:0046848//GO:0004252 protein binding//hydroxyapatite binding//serine-type endopeptidase activity GO:0033644//GO:0005576 host cell membrane//extracellular region KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.35000 BF_2 1358.96 41.53 1656 646714971 KDR18744.1 1884 3.7e-208 26S protease regulatory subunit 6B [Zootermopsis nevadensis] 194762611 XM_001963392.1 392 0 Drosophila ananassae GF20295 (Dana\GF20295), mRNA K03063 PSMC4, RPT3 26S proteasome regulatory subunit T3 http://www.genome.jp/dbget-bin/www_bget?ko:K03063 P46507 1866 1.9e-207 26S protease regulatory subunit 6B OS=Manduca sexta PE=2 SV=1 PF01695//PF07728//PF01057//PF00158//PF00004//PF06414//PF02367//PF00931//PF05496//PF06068//PF07724//PF00005//PF03266//PF07726//PF01637//PF00910 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//NB-ARC domain//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//AAA domain (Cdc48 subfamily)//ABC transporter//NTPase//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//RNA helicase GO:0019079//GO:0006281//GO:0006355//GO:0006310//GO:0002949 viral genome replication//DNA repair//regulation of transcription, DNA-templated//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0098519//GO:0008134//GO:0016887//GO:0016301//GO:0003723//GO:0003678//GO:0043531//GO:0003724//GO:0009378 ATP binding//nucleotide phosphatase activity, acting on free nucleotides//transcription factor binding//ATPase activity//kinase activity//RNA binding//DNA helicase activity//ADP binding//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0727 26S proteasome regulatory complex, ATPase RPT3 Cluster-8309.35001 BF_2 86.13 0.39 9413 546672491 ERL84327.1 5266 0.0e+00 hypothetical protein D910_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 764 6.5e-79 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF02480//PF13895 Alphaherpesvirus glycoprotein E//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.35003 BF_2 734.93 22.51 1653 91079342 XP_969395.1 573 3.9e-56 PREDICTED: chromobox protein homolog 1 [Tribolium castaneum]>gi|270004356|gb|EFA00804.1| hypothetical protein TcasGA2_TC003691 [Tribolium castaneum] -- -- -- -- -- K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 P45973 162 7.2e-10 Chromobox protein homolog 5 OS=Homo sapiens GN=CBX5 PE=1 SV=1 PF01393 Chromo shadow domain -- -- -- -- GO:0005634 nucleus KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.35004 BF_2 9539.64 430.57 1214 642936067 XP_008198289.1 667 3.6e-67 PREDICTED: 60S ribosomal protein L23a-like [Tribolium castaneum]>gi|270014014|gb|EFA10462.1| hypothetical protein TcasGA2_TC012708 [Tribolium castaneum] 807017617 XM_004518966.2 104 8.30698e-45 PREDICTED: Ceratitis capitata 60S ribosomal protein L23a (LOC101463395), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 486 1.4e-47 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0000166//GO:0003735 nucleotide binding//structural constituent of ribosome GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.35005 BF_2 153.49 0.62 10620 817185266 XP_012285919.1 6598 0.0e+00 PREDICTED: neurobeachin isoform X10 [Orussus abietinus] 642919353 XM_008193614.1 1061 0 PREDICTED: Tribolium castaneum neurobeachin (LOC662147), transcript variant X2, mRNA -- -- -- -- Q9W4E2 4768 0.0e+00 Neurobeachin OS=Drosophila melanogaster GN=rg PE=1 SV=3 PF15088//PF10508//PF07127//PF00400 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial//Proteasome non-ATPase 26S subunit//Late nodulin protein//WD domain, G-beta repeat GO:0009878//GO:0043248 nodule morphogenesis//proteasome assembly GO:0046872//GO:0005515 metal ion binding//protein binding GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.35006 BF_2 864.00 18.09 2285 91078330 XP_973321.1 650 6.3e-65 PREDICTED: 15 kDa selenoprotein [Tribolium castaneum]>gi|270003970|gb|EFA00418.1| hypothetical protein TcasGA2_TC003269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z623 364 3.8e-33 15 kDa selenoprotein OS=Sus scrofa GN=SEP15 PE=2 SV=2 PF00096//PF02724 Zinc finger, C2H2 type//CDC45-like protein GO:0006270 DNA replication initiation GO:0046872 metal ion binding -- -- KOG2186 Cell growth-regulating nucleolar protein Cluster-8309.35007 BF_2 1518.35 19.47 3550 91076582 XP_967875.1 1990 4.1e-220 PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912638|ref|XP_008200944.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912640|ref|XP_008200945.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|270002383|gb|EEZ98830.1| hypothetical protein TcasGA2_TC004437 [Tribolium castaneum] 751777425 XM_011199416.1 237 2.8794e-118 PREDICTED: Bactrocera dorsalis probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (LOC105222196), transcript variant X2, mRNA K00602 purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K00602 P31335 1697 1.6e-187 Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1 PF01808//PF00180 AICARFT/IMPCHase bienzyme//Isocitrate/isopropylmalate dehydrogenase GO:0006164//GO:0006144//GO:0055114//GO:0006807 purine nucleotide biosynthetic process//purine nucleobase metabolic process//oxidation-reduction process//nitrogen compound metabolic process GO:0016616//GO:0003937//GO:0004643 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//IMP cyclohydrolase activity//phosphoribosylaminoimidazolecarboxamide formyltransferase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG2555 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase Cluster-8309.35008 BF_2 897.36 7.45 5326 642922291 XP_008193096.1 1316 8.7e-142 PREDICTED: uncharacterized protein LOC661530 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1016 2.2e-108 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF13180//PF02270//PF07544//PF00441//PF04179//PF00595//PF02771//PF02770 PDZ domain//Transcription initiation factor IIF, beta subunit//RNA polymerase II transcription mediator complex subunit 9//Acyl-CoA dehydrogenase, C-terminal domain//Initiator tRNA phosphoribosyl transferase//PDZ domain (Also known as DHR or GLGF)//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0006366//GO:0019988//GO:0008152//GO:0055114//GO:0006367//GO:0006357//GO:0006118 transcription from RNA polymerase II promoter//charged-tRNA amino acid modification//metabolic process//oxidation-reduction process//transcription initiation from RNA polymerase II promoter//regulation of transcription from RNA polymerase II promoter//obsolete electron transport GO:0005515//GO:0001104//GO:0043399//GO:0003995//GO:0016627//GO:0050660 protein binding//RNA polymerase II transcription cofactor activity//tRNA A64-2'-O-ribosylphosphate transferase activity//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding GO:0005674//GO:0016592 transcription factor TFIIF complex//mediator complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.35009 BF_2 646.06 14.47 2155 91094127 XP_968492.1 2115 7.9e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 3.4e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0008235//GO:0004177//GO:0030145 metalloexopeptidase activity//aminopeptidase activity//manganese ion binding GO:0005622//GO:0005737 intracellular//cytoplasm KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.35011 BF_2 274.68 2.47 4940 478258110 ENN78248.1 2446 7.5e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 3.99005e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.9e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF01433//PF09127//PF08063//PF00400//PF01435 Peptidase family M1//Leukotriene A4 hydrolase, C-terminal//PADR1 (NUC008) domain//WD domain, G-beta repeat//Peptidase family M48 GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008270//GO:0008237 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//zinc ion binding//metallopeptidase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.35012 BF_2 11.03 0.36 1563 270014888 EFA11336.1 181 1.0e-10 hypothetical protein TcasGA2_TC010876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35013 BF_2 5.01 0.40 816 546674527 ERL85887.1 325 1.1e-27 hypothetical protein D910_03302 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q5ZK84 242 1.9e-19 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.35015 BF_2 691.25 5.93 5162 642919377 XP_008191846.1 3550 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 831 6.0e-87 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF07714//PF00069//PF01325//PF13895//PF02480 Protein tyrosine kinase//Protein kinase domain//Iron dependent repressor, N-terminal DNA binding domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0003677 protein binding//protein kinase activity//ATP binding//DNA binding GO:0016020 membrane -- -- Cluster-8309.35016 BF_2 468.00 7.03 3072 642923339 XP_008193708.1 3006 0.0e+00 PREDICTED: rab3 GTPase-activating protein catalytic subunit [Tribolium castaneum] -- -- -- -- -- K18270 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K18270 Q15042 1544 7.5e-170 Rab3 GTPase-activating protein catalytic subunit OS=Homo sapiens GN=RAB3GAP1 PE=1 SV=3 PF02025//PF13890 Interleukin 5//Rab3 GTPase-activating protein catalytic subunit GO:0006955//GO:0007165//GO:0040007//GO:0008283 immune response//signal transduction//growth//cell proliferation GO:0005137//GO:0005096//GO:0008083 interleukin-5 receptor binding//GTPase activator activity//growth factor activity GO:0005576//GO:0005895 extracellular region//interleukin-5 receptor complex KOG2390 Uncharacterized conserved protein Cluster-8309.35017 BF_2 4.00 1.41 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35018 BF_2 947.64 25.56 1838 642938919 XP_008195595.1 932 1.0e-97 PREDICTED: suppressor protein SRP40-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03884 Domain of unknown function (DUF329) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.35019 BF_2 506.00 5.43 4188 91080143 XP_968598.1 3802 0.0e+00 PREDICTED: transient-receptor-potential-like protein [Tribolium castaneum]>gi|270006411|gb|EFA02859.1| TRP gamma [Tribolium castaneum] 826443874 XM_012675413.1 168 7.73832e-80 PREDICTED: Monomorium pharaonis transient-receptor-potential-like protein (LOC105833576), transcript variant X2, mRNA K13803 TRPL transient-receptor-potential-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13803 P48994 2688 2.3e-302 Transient-receptor-potential-like protein OS=Drosophila melanogaster GN=trpl PE=1 SV=2 PF00520//PF13606 Ion transport protein//Ankyrin repeat GO:0070588//GO:0055085//GO:0006816//GO:0006811 calcium ion transmembrane transport//transmembrane transport//calcium ion transport//ion transport GO:0005515//GO:0005262//GO:0005216 protein binding//calcium channel activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3609 Receptor-activated Ca2+-permeable cation channels (STRPC family) Cluster-8309.35020 BF_2 251.04 5.16 2323 91087969 XP_973121.1 1160 4.7e-124 PREDICTED: mitochondrial import inner membrane translocase subunit TIM50-C [Tribolium castaneum]>gi|270012048|gb|EFA08496.1| hypothetical protein TcasGA2_TC006148 [Tribolium castaneum] -- -- -- -- -- K17496 TIM50 mitochondrial import inner membrane translocase subunit TIM50 http://www.genome.jp/dbget-bin/www_bget?ko:K17496 Q9W4V8 812 4.3e-85 Mitochondrial import inner membrane translocase subunit TIM50-C OS=Drosophila melanogaster GN=ttm50 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2832 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.35022 BF_2 632.36 20.49 1578 91092934 XP_971990.1 855 7.4e-89 PREDICTED: mitochondrial import inner membrane translocase subunit Tim23 isoform X2 [Tribolium castaneum]>gi|270003027|gb|EEZ99474.1| hypothetical protein TcasGA2_TC000047 [Tribolium castaneum] -- -- -- -- -- K17794 TIM23 mitochondrial import inner membrane translocase subunit TIM23 http://www.genome.jp/dbget-bin/www_bget?ko:K17794 Q9WTQ8 390 2.5e-36 Mitochondrial import inner membrane translocase subunit Tim23 OS=Mus musculus GN=Timm23 PE=2 SV=1 -- -- -- -- -- -- GO:0016021 integral component of membrane KOG3324 Mitochondrial import inner membrane translocase, subunit TIM23 Cluster-8309.35024 BF_2 29.63 0.59 2376 91086235 XP_966692.1 2970 0.0e+00 PREDICTED: transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum]>gi|270011017|gb|EFA07465.1| transitional endoplasmic reticulum ATPase TER94 [Tribolium castaneum] 817081112 XM_012407627.1 599 0 PREDICTED: Athalia rosae transitional endoplasmic reticulum ATPase TER94 (LOC105690094), transcript variant X2, mRNA K13525 VCP, CDC48 transitional endoplasmic reticulum ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K13525 Q7KN62 2819 0.0e+00 Transitional endoplasmic reticulum ATPase TER94 OS=Drosophila melanogaster GN=TER94 PE=1 SV=1 PF00931//PF03152//PF02562//PF02367//PF06414//PF00004//PF01057//PF00158//PF01695//PF07728//PF00910//PF02456//PF01637//PF04851//PF00005//PF07726//PF03266//PF07724//PF00437//PF01443//PF05496//PF06068//PF14532 NB-ARC domain//Ubiquitin fusion degradation protein UFD1//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//RNA helicase//Adenovirus IVa2 protein//Archaeal ATPase//Type III restriction enzyme, res subunit//ABC transporter//ATPase family associated with various cellular activities (AAA)//NTPase//AAA domain (Cdc48 subfamily)//Type II/IV secretion system protein//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//Sigma-54 interaction domain GO:0006310//GO:0006511//GO:0002949//GO:0019083//GO:0019079//GO:0006281//GO:0006810//GO:0006355 DNA recombination//ubiquitin-dependent protein catabolic process//tRNA threonylcarbamoyladenosine modification//viral transcription//viral genome replication//DNA repair//transport//regulation of transcription, DNA-templated GO:0003677//GO:0003723//GO:0003678//GO:0043531//GO:0003724//GO:0017111//GO:0009378//GO:0016787//GO:0098519//GO:0005524//GO:0008134//GO:0016887//GO:0016301 DNA binding//RNA binding//DNA helicase activity//ADP binding//RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//hydrolase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//transcription factor binding//ATPase activity//kinase activity GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0730 AAA+-type ATPase Cluster-8309.35025 BF_2 15.32 0.54 1463 808884880 KKF31755.1 178 2.2e-10 Elongation factor 1-alpha [Larimichthys crocea] 196014369 XM_002117008.1 66 1.33888e-23 Trichoplax adhaerens elongation factor 1 alpha, mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q9YIC0 176 1.5e-11 Elongation factor 1-alpha OS=Oryzias latipes GN=eef1a PE=2 SV=1 PF00503//PF01580 G-protein alpha subunit//FtsK/SpoIIIE family GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0000166//GO:0004871//GO:0019001//GO:0005524//GO:0003677//GO:0031683//GO:0003924 nucleotide binding//signal transducer activity//guanyl nucleotide binding//ATP binding//DNA binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.35026 BF_2 150.54 4.87 1580 91093173 XP_967937.1 401 3.3e-36 PREDICTED: 40S ribosomal protein S21 [Tribolium castaneum]>gi|270012942|gb|EFA09390.1| hypothetical protein TcasGA2_TC004308 [Tribolium castaneum] 645004566 XM_001604620.3 87 3.06977e-35 PREDICTED: Nasonia vitripennis 40S ribosomal protein S21 (LOC100114107), mRNA K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4GXP2 393 1.1e-36 40S ribosomal protein S21 OS=Biphyllus lunatus GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3486 40S ribosomal protein S21 Cluster-8309.35027 BF_2 154.63 3.49 2140 815907605 XP_012239531.1 192 7.6e-12 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01022 Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.35028 BF_2 6.00 0.98 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35030 BF_2 3640.27 115.12 1610 642922960 XP_008200469.1 284 1.2e-22 PREDICTED: uncharacterized protein LOC100142444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35031 BF_2 2343.70 37.70 2888 270009512 EFA05960.1 1547 7.7e-169 hypothetical protein TcasGA2_TC008778 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P20060 1183 5.1e-128 Beta-hexosaminidase subunit beta OS=Mus musculus GN=Hexb PE=2 SV=2 PF08085//PF00728//PF09328//PF08013 Entericidin EcnA/B family//Glycosyl hydrolase family 20, catalytic domain//Domain of unknown function (DUF1984)//Tagatose 6 phosphate kinase GO:0005975//GO:0046938//GO:0010038//GO:0019402//GO:0009636 carbohydrate metabolic process//phytochelatin biosynthetic process//response to metal ion//galactitol metabolic process//response to toxic substance GO:0046872//GO:0016756//GO:0004553 metal ion binding//glutathione gamma-glutamylcysteinyltransferase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0016020 membrane KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.35032 BF_2 233.30 1.68 6109 642932227 XP_008194631.1 501 3.2e-47 PREDICTED: transforming growth factor beta-1-induced transcript 1 protein-like isoform X4 [Tribolium castaneum] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 247 3.7e-19 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01258//PF01853//PF00412 Prokaryotic dksA/traR C4-type zinc finger//MOZ/SAS family//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35033 BF_2 94.15 0.31 13172 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.80773e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.9e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02383//PF13895//PF05461 SacI homology domain//Immunoglobulin domain//Apolipoprotein L GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0042578//GO:0008289 protein binding//phosphoric ester hydrolase activity//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.35034 BF_2 223.00 5.71 1922 642926562 XP_008194921.1 831 5.4e-86 PREDICTED: fasciclin-1-like [Tribolium castaneum]>gi|270009110|gb|EFA05558.1| hypothetical protein TcasGA2_TC015746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 500 5.4e-49 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35035 BF_2 650.00 12.75 2419 189235234 XP_001812254.1 2120 2.3e-235 PREDICTED: SRSF protein kinase 1 [Tribolium castaneum]>gi|270003734|gb|EFA00182.1| hypothetical protein TcasGA2_TC003007 [Tribolium castaneum] 462288448 APGK01055188.1 316 2.37184e-162 Dendroctonus ponderosae Seq01055198, whole genome shotgun sequence K15409 SRPK1 serine/threonine-protein kinase SRPK1 http://www.genome.jp/dbget-bin/www_bget?ko:K15409 Q03563 1217 4.9e-132 Serine/threonine-protein kinase spk-1 OS=Caenorhabditis elegans GN=spk-1 PE=2 SV=3 PF00069//PF07714//PF09201//PF01233 Protein kinase domain//Protein tyrosine kinase//SRX, signal recognition particle receptor alpha subunit//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain GO:0006468//GO:0009069//GO:0016310//GO:0042967 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//acyl-carrier-protein biosynthetic process GO:0004674//GO:0004672//GO:0004379//GO:0005515//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//glycylpeptide N-tetradecanoyltransferase activity//protein binding//ATP binding -- -- KOG1290 Serine/threonine protein kinase Cluster-8309.35036 BF_2 4726.80 51.40 4134 91076582 XP_967875.1 2548 9.4e-285 PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912638|ref|XP_008200944.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|642912640|ref|XP_008200945.1| PREDICTED: bifunctional purine biosynthesis protein PURH [Tribolium castaneum]>gi|270002383|gb|EEZ98830.1| hypothetical protein TcasGA2_TC004437 [Tribolium castaneum] 751777425 XM_011199416.1 237 3.35794e-118 PREDICTED: Bactrocera dorsalis probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (LOC105222196), transcript variant X2, mRNA K00602 purH phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K00602 P31335 2131 8.7e-238 Bifunctional purine biosynthesis protein PURH OS=Gallus gallus GN=ATIC PE=1 SV=1 PF00180//PF01808 Isocitrate/isopropylmalate dehydrogenase//AICARFT/IMPCHase bienzyme GO:0006807//GO:0055114//GO:0006164//GO:0006144 nitrogen compound metabolic process//oxidation-reduction process//purine nucleotide biosynthetic process//purine nucleobase metabolic process GO:0003937//GO:0004643//GO:0016616 IMP cyclohydrolase activity//phosphoribosylaminoimidazolecarboxamide formyltransferase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0042720 mitochondrial inner membrane peptidase complex KOG2555 AICAR transformylase/IMP cyclohydrolase/methylglyoxal synthase Cluster-8309.35037 BF_2 83.88 1.68 2375 546680705 ERL90931.1 2504 6.8e-280 hypothetical protein D910_08274, partial [Dendroctonus ponderosae] 642930215 XM_965099.2 283 5.14747e-144 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 1265 1.3e-137 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.35038 BF_2 841.80 8.63 4366 642926721 XP_008194985.1 1671 4.9e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.1e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.35039 BF_2 1394.49 49.40 1468 642926721 XP_008194985.1 1279 4.7e-138 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4J913 413 5.0e-39 Facilitated trehalose transporter Tret1 OS=Drosophila grimshawi GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.3504 BF_2 18.26 1.08 992 478251152 ENN71628.1 591 1.9e-58 hypothetical protein YQE_11727, partial [Dendroctonus ponderosae]>gi|546685814|gb|ERL95257.1| hypothetical protein D910_12524 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A0JNG4 276 2.6e-23 RING finger protein 207 OS=Bos taurus GN=RNF207 PE=2 SV=1 PF00097//PF00643//PF14634//PF13639//PF16685 Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//Ring finger domain//zinc RING finger of MSL2 -- -- GO:0008270//GO:0061630//GO:0005515//GO:0046872 zinc ion binding//ubiquitin protein ligase activity//protein binding//metal ion binding GO:0005622 intracellular -- -- Cluster-8309.35040 BF_2 224.63 3.28 3156 642918440 XP_008191474.1 1171 3.4e-125 PREDICTED: band 7 protein AGAP004871 isoform X3 [Tribolium castaneum] 157115716 XM_001658225.1 192 2.64861e-93 Aedes aegypti AAEL007320-RA partial mRNA K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q7PPU9 967 6.3e-103 Band 7 protein AGAP004871 OS=Anopheles gambiae GN=AGAP004871 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.35041 BF_2 26.94 0.59 2197 817079106 XP_012261949.1 591 4.2e-58 PREDICTED: nascent polypeptide-associated complex subunit alpha [Athalia rosae]>gi|817079108|ref|XP_012261950.1| PREDICTED: nascent polypeptide-associated complex subunit alpha [Athalia rosae] 346709586 AK384066.1 60 4.38784e-20 Bombyx mori mRNA, clone: fcaL06G10 K03626 EGD2, NACA nascent polypeptide-associated complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03626 Q94518 536 4.1e-53 Nascent polypeptide-associated complex subunit alpha OS=Drosophila melanogaster GN=Nacalpha PE=1 SV=2 PF15328 Putative GRINL1B complex locus protein 2 -- -- -- -- GO:0016591 DNA-directed RNA polymerase II, holoenzyme KOG2239 Transcription factor containing NAC and TS-N domains Cluster-8309.35042 BF_2 167.60 6.23 1412 642925464 XP_008194565.1 397 8.5e-36 PREDICTED: unconventional myosin-XVIIIa isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003735 rRNA binding//structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.35043 BF_2 820.16 34.63 1278 478250485 ENN70980.1 1257 1.5e-135 hypothetical protein YQE_12380, partial [Dendroctonus ponderosae] 157115716 XM_001658225.1 214 6.21924e-106 Aedes aegypti AAEL007320-RA partial mRNA K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q7PPU9 1044 3.0e-112 Band 7 protein AGAP004871 OS=Anopheles gambiae GN=AGAP004871 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.35044 BF_2 83.84 0.75 4962 478250485 ENN70980.1 1238 9.0e-133 hypothetical protein YQE_12380, partial [Dendroctonus ponderosae] 157115716 XM_001658225.1 210 4.12299e-103 Aedes aegypti AAEL007320-RA partial mRNA K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q7PPU9 1036 9.8e-111 Band 7 protein AGAP004871 OS=Anopheles gambiae GN=AGAP004871 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.35045 BF_2 47.00 3.03 936 780089478 XP_011673857.1 278 3.5e-22 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q8N8A2 220 7.7e-17 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35048 BF_2 664.13 18.09 1823 91092778 XP_973837.1 667 5.4e-67 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.3505 BF_2 7.00 0.50 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35050 BF_2 156.79 2.17 3315 91078902 XP_973455.1 765 4.2e-78 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 352 1.4e-31 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF01829//PF08597//PF04632//PF02561//PF05531 Peptidase A6 family//Translation initiation factor eIF3 subunit//Fusaric acid resistance protein family//Flagellar protein FliS//Nucleopolyhedrovirus P10 protein GO:0006508//GO:0006810//GO:0006446 proteolysis//transport//regulation of translational initiation GO:0004190//GO:0003743 aspartic-type endopeptidase activity//translation initiation factor activity GO:0005840//GO:0009288//GO:0005737//GO:0005852//GO:0005886//GO:0019028 ribosome//bacterial-type flagellum//cytoplasm//eukaryotic translation initiation factor 3 complex//plasma membrane//viral capsid KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.35051 BF_2 393.37 9.36 2046 642930028 XP_008196218.1 696 2.6e-70 PREDICTED: homothorax isoform X2 [Tribolium castaneum] 642930027 XM_008197996.1 422 0 PREDICTED: Tribolium castaneum homothorax (Hth), transcript variant X2, mRNA K15613 MEIS1 homeobox protein Meis1 http://www.genome.jp/dbget-bin/www_bget?ko:K15613 O46339 557 1.4e-55 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 PF05920//PF05739//PF00046 Homeobox KN domain//SNARE domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.35052 BF_2 885.00 9.64 4127 642938258 XP_008198133.1 2006 6.6e-222 PREDICTED: rab-like protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U3K5 754 4.1e-78 Rab-like protein 6 OS=Mus musculus GN=Rabl6 PE=1 SV=2 PF00025//PF00071//PF08477//PF09749//PF02724//PF01926 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//Uncharacterised conserved protein//CDC45-like protein//50S ribosome-binding GTPase GO:0007264//GO:0034477//GO:0006270 small GTPase mediated signal transduction//U6 snRNA 3'-end processing//DNA replication initiation GO:0005525//GO:0004518 GTP binding//nuclease activity -- -- -- -- Cluster-8309.35055 BF_2 7682.82 221.22 1740 642933037 XP_008197238.1 659 4.3e-66 PREDICTED: troponin C-like [Tribolium castaneum] 242006313 XM_002423952.1 34 9.82742e-06 Pediculus humanus corporis Troponin C, putative, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P15159 435 1.7e-41 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13499//PF13833//PF00036//PF13405//PF12763//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35056 BF_2 3016.81 53.82 2632 642935906 XP_008198223.1 2244 1.1e-249 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2094 1.1e-233 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF00122//PF09264 E1-E2 ATPase//Vibrio cholerae sialidase, lectin insertion -- -- GO:0046872//GO:0033691//GO:0000166 metal ion binding//sialic acid binding//nucleotide binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35057 BF_2 5.00 1.15 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3506 BF_2 4.00 0.44 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35060 BF_2 19.67 0.79 1326 642924915 XP_008194095.1 540 2.1e-52 PREDICTED: neprilysin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 O16796 329 2.5e-29 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.35063 BF_2 130.07 1.99 3018 478250426 ENN70921.1 505 5.4e-48 hypothetical protein YQE_12323, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BLW3 163 1.0e-09 Leucine-rich repeat-containing G-protein coupled receptor 4 OS=Xenopus tropicalis GN=lgr4 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.35064 BF_2 2674.51 207.63 826 264667363 ACY71267.1 534 6.4e-52 ribosomal protein S24 [Chrysomela tremula] 642917806 XM_962484.3 221 5.09154e-110 PREDICTED: Tribolium castaneum 40S ribosomal protein S24 (LOC655928), mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 511 1.2e-50 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282 Ribosomal protein S24e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-8309.35065 BF_2 91621.83 2941.85 1590 642935906 XP_008198223.1 2248 2.2e-250 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2098 2.2e-234 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF09264//PF00122 Vibrio cholerae sialidase, lectin insertion//E1-E2 ATPase -- -- GO:0000166//GO:0033691//GO:0046872 nucleotide binding//sialic acid binding//metal ion binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35067 BF_2 953.88 37.72 1345 478252371 ENN72797.1 853 1.1e-88 hypothetical protein YQE_10601, partial [Dendroctonus ponderosae] 27616447 BX043166.1 94 3.34326e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC15CD01 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K03521 fixA, etfB electron transfer flavoprotein beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03521 Q9DCW4 679 6.6e-70 Electron transfer flavoprotein subunit beta OS=Mus musculus GN=Etfb PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3180 Electron transfer flavoprotein, beta subunit Cluster-8309.35069 BF_2 1942.52 24.02 3670 189234829 XP_001811696.1 2732 3.8e-306 PREDICTED: protein fem-1 homolog CG6966 isoform X1 [Tribolium castaneum]>gi|270001481|gb|EEZ97928.1| hypothetical protein TcasGA2_TC000315 [Tribolium castaneum] 751210067 XM_011159412.1 147 3.19602e-68 PREDICTED: Solenopsis invicta protein fem-1 homolog CG6966 (LOC105194484), transcript variant X2, mRNA -- -- -- -- Q9VFD5 1696 2.1e-187 Protein fem-1 homolog CG6966 OS=Drosophila melanogaster GN=CG6966 PE=2 SV=2 PF13374//PF13606//PF00023 Tetratricopeptide repeat//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35072 BF_2 360.67 2.75 5778 642924882 XP_008194082.1 2220 1.4e-246 PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|642924884|ref|XP_008194083.1| PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|270008015|gb|EFA04463.1| hypothetical protein TcasGA2_TC014767 [Tribolium castaneum] 795080210 XM_012021821.1 347 3.34119e-179 PREDICTED: Vollenhovia emeryi serine/threonine-protein kinase 25 (LOC105567182), transcript variant X6, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 B0LT89 1090 6.3e-117 Serine/threonine-protein kinase 24 OS=Rattus norvegicus GN=Stk24 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.35074 BF_2 1998.44 59.00 1704 546678022 ERL88746.1 1595 1.2e-174 hypothetical protein D910_06128 [Dendroctonus ponderosae] 642927752 XM_963523.2 171 6.68792e-82 PREDICTED: Tribolium castaneum probable UDP-glucose 4-epimerase (LOC657035), transcript variant X2, mRNA K01784 galE, GALE UDP-glucose 4-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01784 Q9W0P5 1177 1.5e-127 UDP-glucose 4-epimerase OS=Drosophila melanogaster GN=Gale PE=1 SV=1 PF00106//PF01073//PF01370//PF03435//PF02254 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//TrkA-N domain GO:0008210//GO:0008152//GO:0006813//GO:0008207//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//metabolic process//potassium ion transport//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0050662//GO:0003824//GO:0003854//GO:0016491//GO:0016616 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase Cluster-8309.35075 BF_2 1770.18 36.81 2299 571330970 AHF27417.1 1691 1.2e-185 putative sugar transporter 4_1 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.29574e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 941 4.7e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF07690//PF08157//PF00083 Major Facilitator Superfamily//NUC129 domain//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0569 Permease of the major facilitator superfamily Cluster-8309.35076 BF_2 6371.00 913.06 579 264667439 ACY71305.1 721 9.4e-74 ribosomal protein S10 [Chrysomela tremula] 70909510 AM048942.1 119 1.76201e-53 Agriotes lineatus mRNA for ribosomal protein S10e (rpS10e gene) K02947 RP-S10e, RPS10 small subunit ribosomal protein S10e http://www.genome.jp/dbget-bin/www_bget?ko:K02947 Q962R9 585 2.3e-59 40S ribosomal protein S10 OS=Spodoptera frugiperda GN=RpS10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3344 40s ribosomal protein s10 Cluster-8309.35077 BF_2 47.22 0.35 5968 91077054 XP_966585.1 1457 4.4e-158 PREDICTED: probable transaldolase [Tribolium castaneum]>gi|270001740|gb|EEZ98187.1| hypothetical protein TcasGA2_TC000616 [Tribolium castaneum] 746851965 XM_011058220.1 116 8.91725e-51 PREDICTED: Acromyrmex echinatior probable transaldolase (LOC105147307), mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 Q9EQS0 1175 9.0e-127 Transaldolase OS=Rattus norvegicus GN=Taldo1 PE=1 SV=2 PF13855//PF02428//PF00923 Leucine rich repeat//Potato type II proteinase inhibitor family//Transaldolase GO:0006098//GO:0005975 pentose-phosphate shunt//carbohydrate metabolic process GO:0004867//GO:0005515//GO:0004801 serine-type endopeptidase inhibitor activity//protein binding//sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity GO:0005737 cytoplasm KOG2772 Transaldolase Cluster-8309.35078 BF_2 709.80 11.83 2797 546676952 ERL87876.1 1563 1.0e-170 hypothetical protein D910_05264 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 803 5.8e-84 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01700//PF03015//PF08685//PF01370//PF01073 Orbivirus VP3 (T2) protein//Male sterility protein//GON domain//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0005198//GO:0016616//GO:0004222//GO:0003854//GO:0050662//GO:0003824//GO:0080019//GO:0008270 structural molecule activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//metalloendopeptidase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity//zinc ion binding -- -- -- -- Cluster-8309.35079 BF_2 1627.46 18.33 4001 332375078 AEE62680.1 1234 2.1e-132 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14457 MOGAT2, MGAT2 2-acylglycerol O-acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14457 Q70VZ7 681 1.2e-69 2-acylglycerol O-acyltransferase 1 OS=Bos taurus GN=MOGAT1 PE=2 SV=1 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.35080 BF_2 379.00 15.73 1295 820805568 AKG92775.1 812 5.9e-84 enhancer of split mgamma protein 2 [Leptinotarsa decemlineata] 820805567 KP147938.1 220 2.91243e-109 Leptinotarsa decemlineata enhancer of split mgamma protein 2 mRNA, complete cds K09090 HESN hairy and enhancer of split, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09090 Q01069 380 3.0e-35 Enhancer of split mbeta protein OS=Drosophila melanogaster GN=HLHmbeta PE=2 SV=2 PF00010//PF07527 Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.35081 BF_2 51.42 0.49 4700 270011694 EFA08142.1 1444 1.1e-156 hypothetical protein TcasGA2_TC005759 [Tribolium castaneum] 170045052 XM_001850085.1 49 1.23277e-13 Culex quinquefasciatus heparan sulfate glucosamine 3-O-sulfotransferase 3B1, mRNA K07809 HS3ST3 http://www.genome.jp/dbget-bin/www_bget?ko:K07809 Q9QZS6 961 4.6e-102 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 OS=Mus musculus GN=Hs3st3b1 PE=2 SV=2 PF00685//PF00160 Sulfotransferase domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755//GO:0008146 peptidyl-prolyl cis-trans isomerase activity//sulfotransferase activity -- -- KOG3704 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase Cluster-8309.35082 BF_2 1076.14 3.51 13098 642926407 XP_008191950.1 4404 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.18848e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.7e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF03699//PF03325//PF05920//PF02121//PF00046//PF10541//PF02376 Uncharacterised protein family (UPF0182)//Herpesvirus polymerase accessory protein//Homeobox KN domain//Phosphatidylinositol transfer protein//Homeobox domain//Nuclear envelope localisation domain//CUT domain GO:0006355//GO:0006260//GO:0006810//GO:0019079 regulation of transcription, DNA-templated//DNA replication//transport//viral genome replication GO:0030337//GO:0003677 DNA polymerase processivity factor activity//DNA binding GO:0005622//GO:0042575//GO:0016021 intracellular//DNA polymerase complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.35083 BF_2 2.00 12.13 247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35084 BF_2 4.98 0.38 842 642920229 XP_008192257.1 440 5.2e-41 PREDICTED: 60S ribosomal protein L10a isoform X1 [Tribolium castaneum] 315115352 HQ424705.1 140 5.53589e-65 Euphydryas aurinia ribosomal protein L10A (RpL10A) mRNA, complete cds K02865 RP-L10Ae, RPL10A large subunit ribosomal protein L10Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02865 Q963B6 403 4.2e-38 60S ribosomal protein L10a OS=Spodoptera frugiperda GN=RpL10A PE=2 SV=1 PF00468 Ribosomal protein L34 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1570 60S ribosomal protein L10A Cluster-8309.35085 BF_2 40.49 0.77 2484 642927010 XP_008195102.1 871 1.6e-90 PREDICTED: calcium-independent phospholipase A2-gamma-like [Tribolium castaneum] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q9NP80 501 5.3e-49 Calcium-independent phospholipase A2-gamma OS=Homo sapiens GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.35086 BF_2 21.52 0.34 2918 642914025 XP_968806.3 3716 0.0e+00 PREDICTED: cullin-5 [Tribolium castaneum] 157115865 XM_001658270.1 203 1.87798e-99 Aedes aegypti AAEL007353-RA partial mRNA K10612 CUL5 cullin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10612 Q93034 2811 0.0e+00 Cullin-5 OS=Homo sapiens GN=CUL5 PE=1 SV=4 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding -- -- KOG2166 Cullins Cluster-8309.35092 BF_2 8839.22 75.76 5168 642924648 XP_008194379.1 4458 0.0e+00 PREDICTED: tensin isoform X5 [Tribolium castaneum] 642924647 XM_008196157.1 148 1.25492e-68 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X5, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 818 1.9e-85 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.35094 BF_2 355.00 7.39 2296 91080035 XP_972573.1 1102 2.4e-117 PREDICTED: sprT-like domain-containing protein Spartan [Tribolium castaneum]>gi|270004629|gb|EFA01077.1| hypothetical protein TcasGA2_TC003998 [Tribolium castaneum] 194768994 XM_001966557.1 35 3.62342e-06 Drosophila ananassae GF22256 (Dana\GF22256), mRNA -- -- -- -- Q9H040 842 1.4e-88 SprT-like domain-containing protein Spartan OS=Homo sapiens GN=SPRTN PE=1 SV=2 PF15926//PF00942 E3 ubiquitin-protein ligase RNF220//Cellulose binding domain GO:0016567//GO:0005975//GO:0006281//GO:0090263 protein ubiquitination//carbohydrate metabolic process//DNA repair//positive regulation of canonical Wnt signaling pathway GO:0003677//GO:0030248 DNA binding//cellulose binding -- -- KOG3931 Uncharacterized conserved protein Cluster-8309.35095 BF_2 166.99 6.28 1399 478256793 ENN76971.1 289 2.8e-23 hypothetical protein YQE_06539, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35096 BF_2 1050.97 6.47 7078 270006664 EFA03112.1 343 7.8e-29 hypothetical protein TcasGA2_TC013022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15001 AP-5 complex subunit sigma-1 GO:0000724//GO:0016197 double-strand break repair via homologous recombination//endosomal transport -- -- GO:0030119 AP-type membrane coat adaptor complex -- -- Cluster-8309.35097 BF_2 5317.91 33.20 6988 646710887 KDR16277.1 5752 0.0e+00 Myosin-XVIIIa, partial [Zootermopsis nevadensis] 817181759 XM_012425868.1 44 1.1054e-10 PREDICTED: Orussus abietinus unconventional myosin-XVIIIa (LOC105699960), transcript variant X6, mRNA K10362 MYO18 myosin XVIII http://www.genome.jp/dbget-bin/www_bget?ko:K10362 Q92614 3235 0.0e+00 Unconventional myosin-XVIIIa OS=Homo sapiens GN=MYO18A PE=1 SV=3 PF13180//PF01213//PF01418//PF00005//PF01576//PF00063//PF00612//PF00595 PDZ domain//Adenylate cyclase associated (CAP) N terminal//Helix-turn-helix domain, rpiR family//ABC transporter//Myosin tail//Myosin head (motor domain)//IQ calmodulin-binding motif//PDZ domain (Also known as DHR or GLGF) GO:0007010//GO:0006355 cytoskeleton organization//regulation of transcription, DNA-templated GO:0005515//GO:0003779//GO:0005524//GO:0003700//GO:0003774//GO:0016887 protein binding//actin binding//ATP binding//transcription factor activity, sequence-specific DNA binding//motor activity//ATPase activity GO:0005667//GO:0016459 transcription factor complex//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.35099 BF_2 915.14 13.50 3122 189236205 XP_970721.2 1657 1.5e-181 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 71 4.80605e-26 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q91WW7 529 3.8e-52 Patatin-like phospholipase domain-containing protein 3 OS=Mus musculus GN=Pnpla3 PE=2 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.351 BF_2 2.00 0.70 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35100 BF_2 42.00 0.63 3056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35102 BF_2 51.48 1.03 2388 820805538 AKG92760.1 581 6.6e-57 extra macrochaetae [Leptinotarsa decemlineata] 195428687 XM_002062365.1 43 1.34668e-10 Drosophila willistoni GK17519 (Dwil\GK17519), mRNA K17696 EMC DNA-binding protein inhibitor ID, other http://www.genome.jp/dbget-bin/www_bget?ko:K17696 P18491 260 4.5e-21 Protein extra-macrochaetae OS=Drosophila melanogaster GN=emc PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.35103 BF_2 464.00 9.66 2296 91076862 XP_974945.1 1190 1.5e-127 PREDICTED: zinc finger protein Elbow [Tribolium castaneum]>gi|270002797|gb|EEZ99244.1| elbow B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UFS5 332 2.0e-29 Zinc finger protein 503 OS=Danio rerio GN=znf503 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.35104 BF_2 19.68 0.45 2127 642918909 XP_008191651.1 191 9.8e-12 PREDICTED: interaptin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35106 BF_2 52.33 0.56 4206 642928027 XP_008200126.1 1921 4.8e-212 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 5.02035e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 993 8.1e-106 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF05531//PF07851//PF16326//PF04111//PF13499//PF13833//PF13405//PF12763//PF10186//PF01920//PF04728//PF03836//PF00036//PF13202 Nucleopolyhedrovirus P10 protein//TMPIT-like protein//ABC transporter C-terminal domain//Autophagy protein Apg6//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand//Vacuolar sorting 38 and autophagy-related subunit 14//Prefoldin subunit//Lipoprotein leucine-zipper//RasGAP C-terminus//EF hand//EF hand GO:0010508//GO:0007264//GO:0006914//GO:0006457 positive regulation of autophagy//small GTPase mediated signal transduction//autophagy//protein folding GO:0005509//GO:0051082//GO:0005515//GO:0005096//GO:0003677 calcium ion binding//unfolded protein binding//protein binding//GTPase activator activity//DNA binding GO:0016272//GO:0019867//GO:0016021//GO:0019028 prefoldin complex//outer membrane//integral component of membrane//viral capsid KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.35107 BF_2 604.00 14.16 2072 642932259 XP_008197036.1 1125 4.8e-120 PREDICTED: ancient ubiquitous protein 1-like [Tribolium castaneum]>gi|270012314|gb|EFA08762.1| hypothetical protein TcasGA2_TC006447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBN5 367 1.5e-33 Ancient ubiquitous protein 1 OS=Danio rerio GN=aup1 PE=2 SV=2 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35108 BF_2 93.31 0.72 5678 91087085 XP_974959.1 1184 1.9e-126 PREDICTED: phytepsin [Tribolium castaneum]>gi|270010541|gb|EFA06989.1| hypothetical protein TcasGA2_TC009950 [Tribolium castaneum] -- -- -- -- -- K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 593 2.6e-59 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF03145//PF01186//PF00026//PF02176 Seven in absentia protein family//Lysyl oxidase//Eukaryotic aspartyl protease//TRAF-type zinc finger GO:0006508//GO:0006511//GO:0055114//GO:0007275 proteolysis//ubiquitin-dependent protein catabolic process//oxidation-reduction process//multicellular organismal development GO:0008270//GO:0004190//GO:0005507//GO:0016641 zinc ion binding//aspartic-type endopeptidase activity//copper ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0005634 nucleus KOG1339 Aspartyl protease Cluster-8309.35109 BF_2 11.03 0.60 1053 332374430 AEE62356.1 617 1.9e-61 unknown [Dendroctonus ponderosae] 347967155 XM_003435977.1 105 1.99684e-45 Anopheles gambiae str. PEST AGAP002085-PC (AgaP_AGAP002085) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35112 BF_2 38.86 0.33 5223 91094043 XP_968570.1 2945 0.0e+00 PREDICTED: peroxidasin [Tribolium castaneum]>gi|270004795|gb|EFA01243.1| peroxidasin [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q9VZZ4 2310 1.9e-258 Peroxidasin OS=Drosophila melanogaster GN=Pxn PE=1 SV=1 PF13855//PF02480//PF07354//PF13895//PF02918//PF09728 Leucine rich repeat//Alphaherpesvirus glycoprotein E//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Pertussis toxin, subunit 2 and 3, C-terminal domain//Myosin-like coiled-coil protein GO:0006804//GO:0007339//GO:0006979//GO:0009405//GO:0055114 obsolete peroxidase reaction//binding of sperm to zona pellucida//response to oxidative stress//pathogenesis//oxidation-reduction process GO:0019905//GO:0005515//GO:0020037//GO:0004601 syntaxin binding//protein binding//heme binding//peroxidase activity GO:0005576//GO:0016020 extracellular region//membrane KOG2408 Peroxidase/oxygenase Cluster-8309.35114 BF_2 180.81 0.95 8228 91088689 XP_974981.1 866 2.0e-89 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 665810299 XM_008555343.1 133 4.36498e-60 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5A (LOC103575518), transcript variant X2, mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 606 1.2e-60 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF01287//PF13912//PF00560//PF00651//PF00096//PF13855 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//C2H2-type zinc finger//Leucine Rich Repeat//BTB/POZ domain//Zinc finger, C2H2 type//Leucine rich repeat GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0005515//GO:0043022//GO:0003723//GO:0046872//GO:0003746 protein binding//ribosome binding//RNA binding//metal ion binding//translation elongation factor activity GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.35115 BF_2 120.65 2.72 2142 270012283 EFA08731.1 783 2.2e-80 hypothetical protein TcasGA2_TC006406 [Tribolium castaneum] 665810299 XM_008555343.1 133 1.12353e-60 PREDICTED: Microplitis demolitor eukaryotic translation initiation factor 5A (LOC103575518), transcript variant X2, mRNA K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 P62924 727 2.9e-75 Eukaryotic translation initiation factor 5A OS=Spodoptera exigua GN=eIF-5A PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0003723//GO:0043022//GO:0003746 RNA binding//ribosome binding//translation elongation factor activity GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-8309.3512 BF_2 1.00 0.46 376 642922420 XP_008193148.1 246 7.3e-19 PREDICTED: protein lifeguard 3-like [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q8BJZ3 169 2.5e-11 Protein lifeguard 3 OS=Mus musculus GN=Tmbim1 PE=1 SV=1 PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.35120 BF_2 1706.25 14.08 5356 91094499 XP_971436.1 1375 1.3e-148 PREDICTED: phosphopantothenate--cysteine ligase [Tribolium castaneum]>gi|270000749|gb|EEZ97196.1| hypothetical protein TcasGA2_TC004384 [Tribolium castaneum] -- -- -- -- -- K01922 PPCS, coaB phosphopantothenate-cysteine ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01922 Q9HAB8 616 5.3e-62 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2728 Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase Cluster-8309.35121 BF_2 1547.50 101.49 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35123 BF_2 5.96 0.50 782 642922066 XP_966808.3 208 3.9e-14 PREDICTED: putative thiosulfate sulfurtransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q10215 162 3.4e-10 Putative thiosulfate sulfurtransferase, mitochondrial OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC4H3.07c PE=3 SV=2 PF09030 Creb binding GO:0006355//GO:0016573//GO:0042967 regulation of transcription, DNA-templated//histone acetylation//acyl-carrier-protein biosynthetic process GO:0004402//GO:0003713 histone acetyltransferase activity//transcription coactivator activity GO:0000123//GO:0005634//GO:0005667 histone acetyltransferase complex//nucleus//transcription factor complex -- -- Cluster-8309.35124 BF_2 4394.00 567.54 611 91094797 XP_966355.1 389 3.1e-35 PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|642922944|ref|XP_008200463.1| PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|642922946|ref|XP_008200464.1| PREDICTED: elongation factor 1-alpha [Tribolium castaneum]>gi|270006580|gb|EFA03028.1| hypothetical protein TcasGA2_TC010452 [Tribolium castaneum] 759061379 XM_011341716.1 114 1.12272e-50 PREDICTED: Cerapachys biroi elongation factor 1-alpha (LOC105280864), transcript variant X2, mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P19039 371 1.6e-34 Elongation factor 1-alpha OS=Apis mellifera PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0055114//GO:0006184//GO:0006448//GO:0008152//GO:0006414 oxidation-reduction process//obsolete GTP catabolic process//regulation of translational elongation//metabolic process//translational elongation GO:0003746//GO:0005525//GO:0003924//GO:0016491 translation elongation factor activity//GTP binding//GTPase activity//oxidoreductase activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.35126 BF_2 396.00 28.37 871 -- -- -- -- -- 403311088 JX457150.1 811 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35128 BF_2 780.52 2.66 12544 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA -- -- -- -- O16011 771 1.3e-79 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF01522//PF02198//PF00642//PF01607 MMPL family//Polysaccharide deacetylase//Sterile alpha motif (SAM)/Pointed domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Chitin binding Peritrophin-A domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0016810//GO:0008061//GO:0046872//GO:0043565 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding//metal ion binding//sequence-specific DNA binding GO:0005634//GO:0005576//GO:0016020 nucleus//extracellular region//membrane KOG2494 C3H1-type Zn-finger protein Cluster-8309.35129 BF_2 579.00 10.19 2664 642923423 XP_008193738.1 589 8.7e-58 PREDICTED: transmembrane protein 18 [Tribolium castaneum]>gi|270007022|gb|EFA03470.1| hypothetical protein TcasGA2_TC013466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641M3 284 8.3e-24 Transmembrane protein 18 OS=Danio rerio GN=tmem18 PE=2 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.35130 BF_2 63.61 3.06 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35131 BF_2 590.13 11.53 2429 642938996 XP_008200109.1 1048 4.7e-111 PREDICTED: serine protease inhibitor 3/4-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 579 4.7e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35132 BF_2 158.93 2.56 2884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.35133 BF_2 621.31 3.39 7949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03611//PF08115 PTS system sugar-specific permease component//SFI toxin family GO:0009405//GO:0009401 pathogenesis//phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.35134 BF_2 563.05 8.98 2909 642938660 XP_972301.2 1732 2.8e-190 PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum]>gi|642938662|ref|XP_008197697.1| PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum]>gi|642938664|ref|XP_008197706.1| PREDICTED: ornithine aminotransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00819 rocD, OAT ornithine--oxo-acid transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00819 Q9VW26 1401 2.7e-153 Ornithine aminotransferase, mitochondrial OS=Drosophila melanogaster GN=Oat PE=2 SV=1 PF00202 Aminotransferase class-III -- -- GO:0030170//GO:0008483 pyridoxal phosphate binding//transaminase activity -- -- KOG1402 Ornithine aminotransferase Cluster-8309.35135 BF_2 46.74 1.13 2014 642922332 XP_008193116.1 630 1.2e-62 PREDICTED: prickle-like protein 3 isoform X1 [Tribolium castaneum] 642922338 XM_970895.3 209 5.95932e-103 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X5, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 O35115 451 2.7e-43 Four and a half LIM domains protein 2 OS=Rattus norvegicus GN=Fhl2 PE=1 SV=1 PF14634//PF02502//PF00412 zinc-RING finger domain//Ribose/Galactose Isomerase//LIM domain GO:0005975 carbohydrate metabolic process GO:0008270//GO:0005515//GO:0016853 zinc ion binding//protein binding//isomerase activity -- -- KOG1704 FOG: LIM domain Cluster-8309.35136 BF_2 1076.95 166.92 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35137 BF_2 359.45 18.92 1082 642922334 XP_008193117.1 1034 8.9e-110 PREDICTED: four and a half LIM domains protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43900 436 8.0e-42 Prickle-like protein 3 OS=Homo sapiens GN=PRICKLE3 PE=1 SV=2 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.35139 BF_2 1413.89 28.55 2359 642922332 XP_008193116.1 1680 2.4e-184 PREDICTED: prickle-like protein 3 isoform X1 [Tribolium castaneum] 642922336 XM_008194896.1 488 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X4, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 5.3e-107 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF07562//PF00412 Nine Cysteines Domain of family 3 GPCR//LIM domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.35142 BF_2 2248.95 4.87 19592 646716100 KDR19487.1 3053 0.0e+00 E3 ubiquitin-protein ligase MARCH6 [Zootermopsis nevadensis] 847042359 XM_012951711.1 93 1.79317e-37 PREDICTED: Jaculus jaculus membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6), mRNA K10661 MARCH6, DOA10 E3 ubiquitin-protein ligase MARCH6 http://www.genome.jp/dbget-bin/www_bget?ko:K10661 O60337 1868 1.3e-206 E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens GN=MARCH6 PE=1 SV=2 PF12906//PF03165//PF00400//PF00004//PF13639 RING-variant domain//MH1 domain//WD domain, G-beta repeat//ATPase family associated with various cellular activities (AAA)//Ring finger domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008270//GO:0005515 ATP binding//zinc ion binding//protein binding GO:0005622 intracellular KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.35143 BF_2 274.71 4.96 2605 332376669 AEE63474.1 695 4.3e-70 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B5XB27 393 1.9e-36 Kynurenine formamidase OS=Salmo salar GN=afmid PE=2 SV=1 PF00183//PF00326//PF07859 Hsp90 protein//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0006457//GO:0008152//GO:0006950 proteolysis//protein folding//metabolic process//response to stress GO:0008236//GO:0051082//GO:0016787//GO:0005524 serine-type peptidase activity//unfolded protein binding//hydrolase activity//ATP binding -- -- -- -- Cluster-8309.35144 BF_2 39.10 1.77 1212 332376669 AEE63474.1 278 4.6e-22 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01432 AFMID arylformamidase http://www.genome.jp/dbget-bin/www_bget?ko:K01432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35145 BF_2 52.43 0.72 3348 91077070 XP_969313.1 2463 5.5e-275 PREDICTED: metal transporter CNNM4 [Tribolium castaneum]>gi|270002030|gb|EEZ98477.1| hypothetical protein TcasGA2_TC000970 [Tribolium castaneum] 642913385 XM_964220.3 350 0 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q9H8M5 1341 2.8e-146 Metal transporter CNNM2 OS=Homo sapiens GN=CNNM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.35147 BF_2 23.79 2.51 684 678195422 KFV62404.1 186 1.2e-11 hypothetical protein N307_01942, partial [Picoides pubescens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.35148 BF_2 415.41 2.36 7647 546680769 ERL90975.1 1753 2.7e-192 hypothetical protein D910_08317 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P12036 282 4.1e-23 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF03007 Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0046486//GO:0042967//GO:0045017 glycerolipid metabolic process//acyl-carrier-protein biosynthetic process//glycerolipid biosynthetic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.35150 BF_2 41.00 4.82 643 189240245 XP_001810808.1 198 4.6e-13 PREDICTED: uncharacterized protein LOC100141766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35151 BF_2 81.92 2.79 1516 642939160 XP_969591.2 880 8.9e-92 PREDICTED: protein D3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16264 625 1.4e-63 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.35152 BF_2 30.45 0.69 2132 91089929 XP_973045.1 495 5.5e-47 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04309//PF00436 Glycerol-3-phosphate responsive antiterminator//Single-strand binding protein family GO:0009607//GO:0006355 response to biotic stimulus//regulation of transcription, DNA-templated GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.35153 BF_2 1885.60 6.21 12998 642931031 XP_008196185.1 5935 0.0e+00 PREDICTED: Ig-like and fibronectin type-III domain-containing protein T04A11.3 [Tribolium castaneum] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 Q964T2 917 1.6e-96 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF13895//PF00041//PF04893//PF16656//PF01313//PF01108//PF04142//PF00892//PF01266//PF00067 Immunoglobulin domain//Fibronectin type III domain//Yip1 domain//Purple acid Phosphatase, N-terminal domain//Bacterial export proteins, family 3//Tissue factor//Nucleotide-sugar transporter//EamA-like transporter family//FAD dependent oxidoreductase//Cytochrome P450 GO:0019497//GO:0009306//GO:0055114//GO:0008643//GO:0006771 hexachlorocyclohexane metabolic process//protein secretion//oxidation-reduction process//carbohydrate transport//riboflavin metabolic process GO:0005351//GO:0005506//GO:0003993//GO:0016491//GO:0005515//GO:0016705//GO:0046872//GO:0020037 sugar:proton symporter activity//iron ion binding//acid phosphatase activity//oxidoreductase activity//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//metal ion binding//heme binding GO:0016021//GO:0016020//GO:0000139 integral component of membrane//membrane//Golgi membrane -- -- Cluster-8309.35159 BF_2 266.56 3.16 3820 91082907 XP_972373.1 1236 1.2e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.9e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF07224//PF00787//PF00326//PF10503//PF12740 Chlorophyllase//PX domain//Prolyl oligopeptidase family//Esterase PHB depolymerase//Chlorophyllase enzyme GO:0006508//GO:0015996//GO:0015947//GO:0046294//GO:0015994 proteolysis//chlorophyll catabolic process//methane metabolic process//formaldehyde catabolic process//chlorophyll metabolic process GO:0008236//GO:0018738//GO:0035091//GO:0047746 serine-type peptidase activity//S-formylglutathione hydrolase activity//phosphatidylinositol binding//chlorophyllase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.35160 BF_2 803.56 6.84 5204 642911559 XP_970343.3 5016 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF01080//PF06333//PF08074//PF02535//PF00176//PF01874//PF04851//PF02724 Presenilin//Mediator complex subunit 13 C-terminal//CHDCT2 (NUC038) domain//ZIP Zinc transporter//SNF2 family N-terminal domain//ATP:dephospho-CoA triphosphoribosyl transferase//Type III restriction enzyme, res subunit//CDC45-like protein GO:0006270//GO:0055085//GO:0006357//GO:0006355//GO:0016310//GO:0030001 DNA replication initiation//transmembrane transport//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//phosphorylation//metal ion transport GO:0016787//GO:0005524//GO:0016818//GO:0008270//GO:0046917//GO:0004190//GO:0001104//GO:0003677//GO:0046873 hydrolase activity//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//triphosphoribosyl-dephospho-CoA synthase activity//aspartic-type endopeptidase activity//RNA polymerase II transcription cofactor activity//DNA binding//metal ion transmembrane transporter activity GO:0016021//GO:0016592//GO:0005634//GO:0016020 integral component of membrane//mediator complex//nucleus//membrane KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.35164 BF_2 632.36 25.49 1325 642936067 XP_008198289.1 667 3.9e-67 PREDICTED: 60S ribosomal protein L23a-like [Tribolium castaneum]>gi|270014014|gb|EFA10462.1| hypothetical protein TcasGA2_TC012708 [Tribolium castaneum] 807017617 XM_004518966.2 104 9.08907e-45 PREDICTED: Ceratitis capitata 60S ribosomal protein L23a (LOC101463395), mRNA K02893 RP-L23Ae, RPL23A large subunit ribosomal protein L23Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02893 P62752 486 1.6e-47 60S ribosomal protein L23a OS=Rattus norvegicus GN=Rpl23a PE=2 SV=1 PF00276 Ribosomal protein L23 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0000166 structural constituent of ribosome//nucleotide binding GO:0005840 ribosome KOG1751 60s ribosomal protein L23 Cluster-8309.35165 BF_2 958.85 19.82 2311 646707196 KDR14057.1 746 4.7e-76 Ras-related protein Rab-18-B [Zootermopsis nevadensis] -- -- -- -- -- K07910 RAB18 Ras-related protein Rab-18 http://www.genome.jp/dbget-bin/www_bget?ko:K07910 Q6DHC1 723 9.0e-75 Ras-related protein Rab-18-B OS=Danio rerio GN=rab18b PE=2 SV=1 PF00025//PF07475//PF01926//PF08477//PF00735//PF04670//PF00071//PF10662//PF00493//PF00076//PF00005//PF03193 ADP-ribosylation factor family//HPr Serine kinase C-terminal domain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//MCM2/3/5 family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//ABC transporter//Protein of unknown function, DUF258 GO:0006260//GO:0007264//GO:0006576//GO:0000160//GO:0016310//GO:0006109 DNA replication//small GTPase mediated signal transduction//cellular biogenic amine metabolic process//phosphorelay signal transduction system//phosphorylation//regulation of carbohydrate metabolic process GO:0005525//GO:0003676//GO:0016887//GO:0004672//GO:0005524//GO:0000155//GO:0003677//GO:0003924 GTP binding//nucleic acid binding//ATPase activity//protein kinase activity//ATP binding//phosphorelay sensor kinase activity//DNA binding//GTPase activity GO:0009365 protein histidine kinase complex KOG0080 GTPase Rab18, small G protein superfamily Cluster-8309.35166 BF_2 1321.65 15.61 3830 642917906 XP_970904.3 3304 0.0e+00 PREDICTED: probable 3',5'-cyclic phosphodiesterase pde-5 isoform X1 [Tribolium castaneum]>gi|270003323|gb|EEZ99770.1| hypothetical protein TcasGA2_TC002545 [Tribolium castaneum] -- -- -- -- -- K18438 PDE10 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18438 P91119 1631 7.7e-180 Probable 3',5'-cyclic phosphodiesterase pde-5 OS=Caenorhabditis elegans GN=pde-5 PE=3 SV=3 PF13185//PF13492//PF00233//PF01590 GAF domain//GAF domain//3'5'-cyclic nucleotide phosphodiesterase//GAF domain GO:0007165//GO:0008152//GO:0006144 signal transduction//metabolic process//purine nucleobase metabolic process GO:0004114//GO:0046872//GO:0005515 3',5'-cyclic-nucleotide phosphodiesterase activity//metal ion binding//protein binding -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.35167 BF_2 7.15 0.37 1091 642913579 XP_008201071.1 283 1.1e-22 PREDICTED: succinate dehydrogenase cytochrome b560 subunit, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K00236 SDHC, SDH3 succinate dehydrogenase (ubiquinone) cytochrome b560 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00236 Q99643 190 2.7e-13 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial OS=Homo sapiens GN=SDHC PE=1 SV=1 PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0449 Succinate dehydrogenase, cytochrome b subunit Cluster-8309.35168 BF_2 587.00 19.14 1570 546677591 ERL88396.1 886 1.9e-92 hypothetical protein D910_05782 [Dendroctonus ponderosae] -- -- -- -- -- K17292 TBCA tubulin-specific chaperone A http://www.genome.jp/dbget-bin/www_bget?ko:K17292 Q6PEC1 277 3.2e-23 Tubulin-specific chaperone A OS=Rattus norvegicus GN=Tbca PE=1 SV=1 PF02970 Tubulin binding cofactor A GO:0007021 tubulin complex assembly GO:0015631//GO:0051082 tubulin binding//unfolded protein binding GO:0045298 tubulin complex KOG3470 Beta-tubulin folding cofactor A Cluster-8309.35169 BF_2 87.23 1.82 2295 270006792 EFA03240.1 481 2.5e-45 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 308 1.2e-26 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF07994 Myo-inositol-1-phosphate synthase GO:0008654//GO:0006021//GO:0019872 phospholipid biosynthetic process//inositol biosynthetic process//streptomycin biosynthetic process GO:0004512 inositol-3-phosphate synthase activity -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35170 BF_2 34.98 0.81 2088 329762922 AEC04842.1 273 3.0e-21 chemosensory protein [Batocera horsfieldi] 329762921 HQ587040.1 197 2.8967e-96 Batocera horsfieldi chemosensory protein (CSP1) mRNA, complete cds -- -- -- -- Q9W1C9 153 1.0e-08 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF03790 KNOX1 domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.35171 BF_2 1928.78 71.22 1420 478257902 ENN78042.1 440 8.8e-41 hypothetical protein YQE_05479, partial [Dendroctonus ponderosae] -- -- -- -- -- K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 -- -- -- -- PF10408 Ubiquitin elongating factor core GO:0016567//GO:0006511 protein ubiquitination//ubiquitin-dependent protein catabolic process GO:0034450 ubiquitin-ubiquitin ligase activity GO:0000151 ubiquitin ligase complex -- -- Cluster-8309.35172 BF_2 607.47 48.33 813 642937735 XP_008198925.1 703 1.6e-71 PREDICTED: tropomyosin-1, isoforms 9A/A/B isoform X18 [Tribolium castaneum] 780660607 XM_011694427.1 174 6.71147e-84 PREDICTED: Wasmannia auropunctata tropomyosin (LOC105452880), transcript variant X17, mRNA K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 P06754 574 6.0e-58 Tropomyosin-1, isoforms 9A/A/B OS=Drosophila melanogaster GN=Tm1 PE=2 SV=2 PF10186//PF00769//PF16716//PF07926//PF02185//PF06009 Vacuolar sorting 38 and autophagy-related subunit 14//Ezrin/radixin/moesin family//Bone marrow stromal antigen 2//TPR/MLP1/MLP2-like protein//Hr1 repeat//Laminin Domain II GO:0051607//GO:0007165//GO:0010508//GO:0006606//GO:0007155 defense response to virus//signal transduction//positive regulation of autophagy//protein import into nucleus//cell adhesion GO:0008092 cytoskeletal protein binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35174 BF_2 137.63 1.83 3432 642926071 XP_008194753.1 2593 4.7e-290 PREDICTED: transcription elongation factor SPT5 [Tribolium castaneum]>gi|270008998|gb|EFA05446.1| hypothetical protein TcasGA2_TC015626 [Tribolium castaneum] 158293810 XM_001231044.2 279 1.24967e-141 Anopheles gambiae str. PEST AGAP005021-PA (AgaP_AGAP005021) mRNA, complete cds K15172 SUPT5H, SPT5 transcription elongation factor SPT5 http://www.genome.jp/dbget-bin/www_bget?ko:K15172 Q9V460 2092 2.4e-233 Transcription elongation factor SPT5 OS=Drosophila melanogaster GN=Spt5 PE=1 SV=1 PF07267//PF05460//PF02932//PF03999 Nucleopolyhedrovirus capsid protein P87//Origin recognition complex subunit 6 (ORC6)//Neurotransmitter-gated ion-channel transmembrane region//Microtubule associated protein (MAP65/ASE1 family) GO:0032968//GO:0000910//GO:0006811//GO:0000226//GO:0006260 positive regulation of transcription elongation from RNA polymerase II promoter//cytokinesis//ion transport//microtubule cytoskeleton organization//DNA replication GO:0003677//GO:0008017 DNA binding//microtubule binding GO:0005664//GO:0045298//GO:0019028//GO:0016020 nuclear origin of replication recognition complex//tubulin complex//viral capsid//membrane KOG1999 RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 Cluster-8309.35175 BF_2 43.28 2.80 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35176 BF_2 922.43 5.82 6918 642918310 XP_008191453.1 3659 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 3.8e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00168//PF01530//PF01017 C2 domain//Zinc finger, C2HC type//STAT protein, all-alpha domain GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0008270//GO:0004871 protein binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//signal transducer activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.35177 BF_2 2586.52 8.70 12719 817208819 XP_012280436.1 6915 0.0e+00 PREDICTED: uncharacterized protein LOC105699757 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9U943 866 1.3e-90 Apolipophorins OS=Locusta migratoria PE=1 SV=2 PF06448//PF01347//PF09172 Domain of Unknown Function (DUF1081)//Lipoprotein amino terminal region//Domain of unknown function (DUF1943) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- KOG4338 Predicted lipoprotein Cluster-8309.35178 BF_2 664.61 20.49 1644 642912151 XP_008200828.1 1158 5.6e-124 PREDICTED: uridine phosphorylase 1-like isoform X1 [Tribolium castaneum]>gi|270002489|gb|EEZ98936.1| hypothetical protein TcasGA2_TC004559 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 P52624 626 1.1e-63 Uridine phosphorylase 1 OS=Mus musculus GN=Upp1 PE=1 SV=2 PF01048 Phosphorylase superfamily GO:0006206//GO:0009116//GO:0009166 pyrimidine nucleobase metabolic process//nucleoside metabolic process//nucleotide catabolic process GO:0004850//GO:0003824 uridine phosphorylase activity//catalytic activity GO:0005737 cytoplasm KOG3728 Uridine phosphorylase Cluster-8309.35179 BF_2 5139.47 32.43 6917 642930669 XP_008199217.1 1785 4.7e-196 PREDICTED: uncharacterized protein LOC657834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12036 282 3.7e-23 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF03007 Wax ester synthase-like Acyl-CoA acyltransferase domain GO:0045017//GO:0046486//GO:0042967 glycerolipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.35181 BF_2 56.02 2.93 1087 332374344 AEE62313.1 1081 3.2e-115 unknown [Dendroctonus ponderosae]>gi|478253634|gb|ENN73938.1| hypothetical protein YQE_09440, partial [Dendroctonus ponderosae]>gi|546684541|gb|ERL94169.1| hypothetical protein D910_11451 [Dendroctonus ponderosae] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q3B7M2 858 9.4e-91 Hydroxyacylglutathione hydrolase, mitochondrial OS=Bos taurus GN=HAGH PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0813 Glyoxylase Cluster-8309.35183 BF_2 3758.00 46.68 3655 91088385 XP_972387.1 1045 1.6e-110 PREDICTED: cytosolic Fe-S cluster assembly factor NUBP2 homolog [Tribolium castaneum]>gi|270011770|gb|EFA08218.1| hypothetical protein TcasGA2_TC005845 [Tribolium castaneum] 53830697 AY725779.1 166 8.72513e-79 Oncometopia nigricans putative cytoplasmic actin A3a1 mRNA, complete cds -- -- -- -- Q16H50 904 1.5e-95 Cytosolic Fe-S cluster assembly factor NUBP2 homolog OS=Aedes aegypti GN=AAEL008143 PE=3 SV=1 PF13181//PF01583//PF00448//PF13174//PF03205//PF00515//PF06414//PF13371//PF03266//PF03193//PF00931//PF13176//PF13414 Tetratricopeptide repeat//Adenylylsulphate kinase//SRP54-type protein, GTPase domain//Tetratricopeptide repeat//Molybdopterin guanine dinucleotide synthesis protein B//Tetratricopeptide repeat//Zeta toxin//Tetratricopeptide repeat//NTPase//Protein of unknown function, DUF258//NB-ARC domain//Tetratricopeptide repeat//TPR repeat GO:0000103//GO:0006144//GO:0006614//GO:0006777 sulfate assimilation//purine nucleobase metabolic process//SRP-dependent cotranslational protein targeting to membrane//Mo-molybdopterin cofactor biosynthetic process GO:0003924//GO:0004020//GO:0005515//GO:0043531//GO:0098519//GO:0005524//GO:0016301//GO:0005525 GTPase activity//adenylylsulfate kinase activity//protein binding//ADP binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//kinase activity//GTP binding -- -- KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.35184 BF_2 356.11 2.93 5375 642924658 XP_008194384.1 4650 0.0e+00 PREDICTED: tensin isoform X10 [Tribolium castaneum] 642924663 XM_008196165.1 42 1.09866e-09 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X13, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q04205 811 1.3e-84 Tensin OS=Gallus gallus GN=TNS PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.35185 BF_2 559.90 6.98 3641 91083607 XP_969406.1 1301 3.3e-140 PREDICTED: solute carrier family 25 member 44 [Tribolium castaneum]>gi|270007841|gb|EFA04289.1| hypothetical protein TcasGA2_TC014580 [Tribolium castaneum] -- -- -- -- -- K15121 SLC25A44 solute carrier family 25, member 44 http://www.genome.jp/dbget-bin/www_bget?ko:K15121 Q5RD67 658 4.9e-67 Solute carrier family 25 member 44 OS=Pongo abelii GN=SLC25A44 PE=2 SV=2 PF03689//PF00096 Nepovirus coat protein, N-terminal domain//Zinc finger, C2H2 type GO:0055085 transmembrane transport GO:0046872 metal ion binding GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG0765 Predicted mitochondrial carrier protein Cluster-8309.35186 BF_2 1700.97 19.80 3881 589060792 AHK26789.1 3719 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 1.51862e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2874 0.0e+00 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF08138//PF00682//PF05896 Sex peptide (SP) family//HMGL-like//Na(+)-translocating NADH-quinone reductase subunit A (NQRA) GO:0055114//GO:0046008//GO:0006814//GO:0006118//GO:0007165 oxidation-reduction process//regulation of female receptivity, post-mating//sodium ion transport//obsolete electron transport//signal transduction GO:0016655//GO:0005179//GO:0003824 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//hormone activity//catalytic activity GO:0005576 extracellular region KOG0369 Pyruvate carboxylase Cluster-8309.35187 BF_2 50.79 1.07 2266 642922975 XP_008200476.1 1247 3.7e-134 PREDICTED: growth hormone-regulated TBC protein 1 [Tribolium castaneum]>gi|270006542|gb|EFA02990.1| hypothetical protein TcasGA2_TC010409 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TC63 719 2.6e-74 Growth hormone-regulated TBC protein 1 OS=Homo sapiens GN=GRTP1 PE=1 SV=4 PF00947 Picornavirus core protein 2A GO:0006508//GO:0016032 proteolysis//viral process GO:0008233 peptidase activity GO:0005622 intracellular KOG2058 Ypt/Rab GTPase activating protein Cluster-8309.35189 BF_2 126.29 2.77 2196 761896177 AJP75146.1 1663 2.1e-182 alanine aminotransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00814 GPT, ALT alanine transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00814 Q6GM82 1162 1.1e-125 Alanine aminotransferase 2 OS=Xenopus laevis GN=gpt2 PE=2 SV=1 PF01212//PF00155 Beta-eliminating lyase//Aminotransferase class I and II GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG0258 Alanine aminotransferase Cluster-8309.35190 BF_2 681.00 7.37 4153 642919333 XP_008191829.1 1602 4.7e-175 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AVA0 285 9.9e-24 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 OS=Mus musculus GN=Svep1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35191 BF_2 7497.00 453.97 978 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35192 BF_2 600.95 20.56 1510 270006122 EFA02570.1 416 5.7e-38 hypothetical protein TcasGA2_TC008280 [Tribolium castaneum] -- -- -- -- -- K06850 SLIT3 slit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06850 O75094 173 3.5e-11 Slit homolog 3 protein OS=Homo sapiens GN=SLIT3 PE=2 SV=3 PF13413//PF00560//PF13516//PF13855 Helix-turn-helix domain//Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.35193 BF_2 65.00 4.87 846 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35195 BF_2 652.46 11.70 2619 546670831 ERL83427.1 3655 0.0e+00 hypothetical protein D910_00401 [Dendroctonus ponderosae] 242021484 XM_002431130.1 400 0 Pediculus humanus corporis protein transport protein Sec23A, putative, mRNA K14006 SEC23 protein transport protein SEC23 http://www.genome.jp/dbget-bin/www_bget?ko:K14006 Q01405 3143 0.0e+00 Protein transport protein Sec23A OS=Mus musculus GN=Sec23a PE=1 SV=2 PF04810//PF04811//PF04815 Sec23/Sec24 zinc finger//Sec23/Sec24 trunk domain//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1986 Vesicle coat complex COPII, subunit SEC23 Cluster-8309.35196 BF_2 1767.96 32.05 2595 478257623 ENN77775.1 3674 0.0e+00 hypothetical protein YQE_05747, partial [Dendroctonus ponderosae] 242021484 XM_002431130.1 426 0 Pediculus humanus corporis protein transport protein Sec23A, putative, mRNA K14006 SEC23 protein transport protein SEC23 http://www.genome.jp/dbget-bin/www_bget?ko:K14006 Q01405 3162 0.0e+00 Protein transport protein Sec23A OS=Mus musculus GN=Sec23a PE=1 SV=2 PF04810//PF04811//PF04815 Sec23/Sec24 zinc finger//Sec23/Sec24 trunk domain//Sec23/Sec24 helical domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1986 Vesicle coat complex COPII, subunit SEC23 Cluster-8309.35198 BF_2 573.20 34.76 977 156523066 NP_001095946.1 269 4.1e-21 chitin deacetylase 1 precursor [Tribolium castaneum]>gi|155675830|gb|ABU25223.1| chitin deacetylase 1 [Tribolium castaneum]>gi|270007508|gb|EFA03956.1| hypothetical protein TcasGA2_TC014100 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005975//GO:0006040//GO:0006030 carbohydrate metabolic process//amino sugar metabolic process//chitin metabolic process GO:0008061//GO:0004099 chitin binding//chitin deacetylase activity GO:0005576 extracellular region -- -- Cluster-8309.35199 BF_2 48.67 1.06 2213 91081961 XP_966594.1 184 6.6e-11 PREDICTED: Y-box factor homolog isoform X1 [Tribolium castaneum]>gi|270007364|gb|EFA03812.1| hypothetical protein TcasGA2_TC013925 [Tribolium castaneum] 462328436 APGK01040697.1 43 1.24652e-10 Dendroctonus ponderosae Seq01040707, whole genome shotgun sequence K09276 YBX1, NSEP1 Y-box-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09276 P41824 173 5.1e-11 Y-box factor homolog OS=Aplysia californica PE=2 SV=1 PF00313 'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.352 BF_2 2.00 0.93 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3520 BF_2 9.99 0.31 1656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35200 BF_2 835.70 6.43 5723 546675647 ERL86797.1 3344 0.0e+00 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 106 3.09658e-45 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 2100 4.7e-234 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF02888//PF00454 Calmodulin binding domain//Phosphatidylinositol 3- and 4-kinase GO:0006813 potassium ion transport GO:0015269//GO:0016773//GO:0005516 calcium-activated potassium channel activity//phosphotransferase activity, alcohol group as acceptor//calmodulin binding GO:0016021 integral component of membrane KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) Cluster-8309.35202 BF_2 49.29 0.71 3176 478255961 ENN76162.1 825 4.5e-85 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] 264667412 GU120442.1 190 3.44815e-92 Chrysomela tremulae ribosomal protein L27 (RpL27) mRNA, complete cds K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 P70423 536 6.0e-53 Cationic amino acid transporter 3 OS=Mus musculus GN=Slc7a3 PE=2 SV=1 PF00324//PF13520//PF01777 Amino acid permease//Amino acid permease//Ribosomal L27e protein family GO:0042254//GO:0003333//GO:0006412//GO:0006810//GO:0006865//GO:0055085 ribosome biogenesis//amino acid transmembrane transport//translation//transport//amino acid transport//transmembrane transport GO:0003735//GO:0015171 structural constituent of ribosome//amino acid transmembrane transporter activity GO:0005840//GO:0005622//GO:0016020 ribosome//intracellular//membrane -- -- Cluster-8309.35203 BF_2 321.00 4.03 3616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35204 BF_2 74.82 1.98 1870 270013707 EFA10155.1 376 3.1e-33 hypothetical protein TcasGA2_TC012343 [Tribolium castaneum] 642934429 XM_008199437.1 54 8.06144e-17 PREDICTED: Tribolium castaneum mitochondrial Rho GTPase (LOC657284), transcript variant X1, mRNA K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 270 2.5e-22 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.35205 BF_2 36.14 0.94 1888 91094775 XP_968026.1 520 6.2e-50 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9I1 145 7.7e-08 Cyclin-G1 OS=Bos taurus GN=CCNG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35206 BF_2 30.95 0.32 4316 642935120 XP_008197896.1 5125 0.0e+00 PREDICTED: vigilin [Tribolium castaneum]>gi|270013832|gb|EFA10280.1| hypothetical protein TcasGA2_TC012484 [Tribolium castaneum] 642935119 XM_008199674.1 969 0 PREDICTED: Tribolium castaneum vigilin (LOC658150), mRNA -- -- -- -- Q00341 3321 0.0e+00 Vigilin OS=Homo sapiens GN=HDLBP PE=1 SV=2 PF00013//PF13014//PF13184//PF07650 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2208 Vigilin Cluster-8309.35208 BF_2 148.02 1.48 4466 642937760 XP_008198934.1 1304 1.8e-140 PREDICTED: mortality factor 4-like protein 1 [Tribolium castaneum]>gi|270001152|gb|EEZ97599.1| hypothetical protein TcasGA2_TC011468 [Tribolium castaneum] 807018879 XM_004519732.2 70 2.48138e-25 PREDICTED: Ceratitis capitata nuA4 complex subunit EAF3 homolog (LOC101448544), mRNA K11339 MORF4L1, MRG15, EAF3 mortality factor 4-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11339 Q6AYU1 950 8.3e-101 Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.35209 BF_2 110.00 1.35 3707 642926858 XP_008195042.1 912 4.3e-95 PREDICTED: RIMS-binding protein 2 [Tribolium castaneum] 642916156 XM_008192687.1 95 2.60405e-39 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X5, mRNA K17591 RIMBP2 RIMS-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17591 O15034 456 1.3e-43 RIMS-binding protein 2 OS=Homo sapiens GN=RIMBP2 PE=1 SV=3 PF06236//PF14604//PF00018//PF03153 Tyrosinase co-factor MelC1//Variant SH3 domain//SH3 domain//Transcription factor IIA, alpha/beta subunit GO:0042438//GO:0006367 melanin biosynthetic process//transcription initiation from RNA polymerase II promoter GO:0005507//GO:0005515 copper ion binding//protein binding GO:0005672 transcription factor TFIIA complex KOG3632 Peripheral benzodiazepine receptor PRAX-1 Cluster-8309.35210 BF_2 1130.63 9.86 5086 189235271 XP_973061.2 1267 4.0e-136 PREDICTED: MKL/myocardin-like protein 2 isoform X1 [Tribolium castaneum] 642916156 XM_008192687.1 95 3.58226e-39 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X5, mRNA -- -- -- -- Q8K4J6 314 5.3e-27 MKL/myocardin-like protein 1 OS=Mus musculus GN=Mkl1 PE=1 SV=2 PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- -- -- Cluster-8309.35212 BF_2 1933.00 54.35 1775 2654204 AAC63079.1 999 1.7e-105 putative juvenile hormone esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35214 BF_2 8509.99 172.24 2354 332374512 AEE62397.1 1661 3.8e-182 unknown [Dendroctonus ponderosae]>gi|478256842|gb|ENN77017.1| hypothetical protein YQE_06511, partial [Dendroctonus ponderosae]>gi|546673798|gb|ERL85342.1| hypothetical protein D910_02762 [Dendroctonus ponderosae] 557020770 XM_006010638.1 35 3.71637e-06 PREDICTED: Latimeria chalumnae alcohol dehydrogenase class-3-like (LOC102353852), mRNA K00121 frmA, ADH5, adhC S-(hydroxymethyl)glutathione dehydrogenase / alcohol dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00121 P79896 1475 5.8e-162 Alcohol dehydrogenase class-3 OS=Sparus aurata PE=2 SV=1 PF08240//PF02826//PF03721//PF00107 Alcohol dehydrogenase GroES-like domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0051287//GO:0016616 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG0022 Alcohol dehydrogenase, class III Cluster-8309.35215 BF_2 4548.27 432.57 727 91093619 XP_972048.1 469 2.0e-44 PREDICTED: 60S ribosomal protein L26 [Tribolium castaneum]>gi|270015756|gb|EFA12204.1| hypothetical protein TcasGA2_TC005120 [Tribolium castaneum] 70909792 AM049083.1 215 9.6436e-107 Curculio glandium mRNA for ribosomal protein L26e (rpL26e gene) K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61254 391 8.9e-37 60S ribosomal protein L26 OS=Homo sapiens GN=RPL26 PE=1 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG3401 60S ribosomal protein L26 Cluster-8309.35217 BF_2 2758.00 61.02 2178 189241091 XP_001811274.1 1894 3.4e-209 PREDICTED: 4F2 cell-surface antigen heavy chain [Tribolium castaneum]>gi|270013351|gb|EFA09799.1| hypothetical protein TcasGA2_TC011942 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10852 254 2.0e-20 4F2 cell-surface antigen heavy chain OS=Mus musculus GN=Slc3a2 PE=1 SV=1 PF00128//PF00443 Alpha amylase, catalytic domain//Ubiquitin carboxyl-terminal hydrolase GO:0005975//GO:0016579 carbohydrate metabolic process//protein deubiquitination GO:0003824//GO:0036459//GO:0043169 catalytic activity//ubiquitinyl hydrolase activity//cation binding -- -- KOG0471 Alpha-amylase Cluster-8309.35218 BF_2 27.04 0.76 1773 669214630 CDW61305.1 238 2.9e-17 hypothetical protein TTRE_0000975601 [Trichuris trichiura] 56968029 AY859575.1 418 0 Gaetice depressus 5.8S ribosomal RNA gene, partial sequence; internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 197 6.8e-14 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35219 BF_2 1780.14 23.57 3447 642921485 XP_966806.2 2283 4.2e-254 PREDICTED: uncharacterized protein LOC655197 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9S777 822 4.4e-86 4-coumarate--CoA ligase 3 OS=Arabidopsis thaliana GN=4CL3 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.35221 BF_2 286.00 27.96 715 194767015 XP_001965614.1 183 2.8e-11 GF22361 [Drosophila ananassae]>gi|190619605|gb|EDV35129.1| GF22361 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- D2WKD9 171 2.8e-11 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 -- -- GO:0008152 metabolic process -- -- -- -- -- -- Cluster-8309.35223 BF_2 329.83 2.77 5266 91082885 XP_971739.1 1098 1.6e-116 PREDICTED: leucine-rich repeat extensin-like protein 3 [Tribolium castaneum]>gi|270007607|gb|EFA04055.1| hypothetical protein TcasGA2_TC014287 [Tribolium castaneum] 642923275 XM_966646.2 63 2.28071e-21 PREDICTED: Tribolium castaneum leucine-rich repeat extensin-like protein 3 (LOC660415), mRNA -- -- -- -- Q9C0B9 157 8.8e-09 Zinc finger CCHC domain-containing protein 2 OS=Homo sapiens GN=ZCCHC2 PE=1 SV=6 PF00098//PF03608 Zinc knuckle//PTS system enzyme II sorbitol-specific factor GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.35227 BF_2 3898.77 74.17 2486 546682338 ERL92286.1 1172 2.0e-125 hypothetical protein D910_09603 [Dendroctonus ponderosae] -- -- -- -- -- K15728 LPIN phosphatidate phosphatase LPIN http://www.genome.jp/dbget-bin/www_bget?ko:K15728 Q7TNN8 385 1.5e-35 Phosphatidate phosphatase LPIN3 OS=Mus spretus GN=Lpin3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2116 Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism Cluster-8309.35228 BF_2 5731.84 223.91 1358 833654169 AKM28424.1 837 7.8e-87 fatty acid synthase 2 [Aphis gossypii] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 522 1.1e-51 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF16093//PF00975//PF00025 Proteasome assembly chaperone 4//Thioesterase domain//ADP-ribosylation factor family GO:0009058//GO:0043248 biosynthetic process//proteasome assembly GO:0016788//GO:0005525 hydrolase activity, acting on ester bonds//GTP binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.35229 BF_2 2312.32 105.97 1200 546672885 ERL84608.1 1032 1.7e-109 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 859 7.9e-91 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00106//PF00107 short chain dehydrogenase//Zinc-binding dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.35231 BF_2 847.93 5.19 7118 270001906 EEZ98353.1 206 6.0e-13 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35232 BF_2 5609.00 655.66 645 642920635 XP_008192497.1 153 7.6e-08 PREDICTED: cuticle protein 63 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35234 BF_2 31.77 0.56 2651 91076170 XP_971503.1 2162 3.5e-240 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 401 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.3e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.35235 BF_2 3097.39 30.82 4491 91083703 XP_969630.1 2122 2.5e-235 PREDICTED: monocarboxylate transporter 5 [Tribolium castaneum]>gi|270007880|gb|EFA04328.1| hypothetical protein TcasGA2_TC014622 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GM59 412 2.0e-38 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.35236 BF_2 1303.00 18.91 3170 478250492 ENN70987.1 2095 2.4e-232 hypothetical protein YQE_12387, partial [Dendroctonus ponderosae] 332372497 BT126427.1 262 3.25219e-132 Dendroctonus ponderosae clone DPO016_I09 unknown mRNA K06272 ILK integrin-linked kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06272 Q5R5V4 1513 3.1e-166 Integrin-linked protein kinase OS=Pongo abelii GN=ILK PE=2 SV=1 PF13606//PF07714//PF00023//PF00069 Ankyrin repeat//Protein tyrosine kinase//Ankyrin repeat//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG0195 Integrin-linked kinase Cluster-8309.35237 BF_2 2588.64 10.82 10295 270001965 EEZ98412.1 2469 3.4e-275 hypothetical protein TcasGA2_TC000880 [Tribolium castaneum] 551500202 XM_005801594.1 175 2.45492e-83 PREDICTED: Xiphophorus maculatus zinc finger MIZ domain-containing protein 1-like (LOC102237688), mRNA -- -- -- -- Q6P1E1 1311 2.6e-142 Zinc finger MIZ domain-containing protein 1 OS=Mus musculus GN=Zmiz1 PE=2 SV=1 PF11789//PF03917//PF03199//PF02891 Zinc-finger of the MIZ type in Nse subunit//Eukaryotic glutathione synthase, ATP binding domain//Eukaryotic glutathione synthase//MIZ/SP-RING zinc finger GO:0006750 glutathione biosynthetic process GO:0004363//GO:0005524//GO:0008270 glutathione synthase activity//ATP binding//zinc ion binding -- -- KOG0021 Glutathione synthetase Cluster-8309.35239 BF_2 435.30 4.40 4428 478253025 ENN73405.1 1553 2.4e-169 hypothetical protein YQE_09967, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P02567 165 8.7e-10 Myosin-1 OS=Caenorhabditis elegans GN=myo-1 PE=1 SV=3 PF13851//PF08702//PF05531//PF07989 Growth-arrest specific micro-tubule binding//Fibrinogen alpha/beta chain family//Nucleopolyhedrovirus P10 protein//Centrosomin N-terminal motif 1 GO:0030168//GO:0051258//GO:0048870//GO:0007165 platelet activation//protein polymerization//cell motility//signal transduction GO:0030674//GO:0005102 protein binding, bridging//receptor binding GO:0005577//GO:0005815//GO:0019028//GO:0031514 fibrinogen complex//microtubule organizing center//viral capsid//motile cilium -- -- Cluster-8309.35240 BF_2 81.72 0.88 4172 91080257 XP_973323.1 2311 2.9e-257 PREDICTED: T-complex protein 1 subunit delta [Tribolium castaneum]>gi|270005693|gb|EFA02141.1| hypothetical protein TcasGA2_TC007791 [Tribolium castaneum] 641791443 XM_005305637.2 106 2.25206e-45 PREDICTED: Chrysemys picta bellii chaperonin containing TCP1, subunit 4 (delta) (CCT4), mRNA K09496 CCT4 T-complex protein 1 subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K09496 Q9NB32 2088 8.5e-233 T-complex protein 1 subunit delta OS=Ochlerotatus triseriatus PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0005737 cytoplasm KOG0358 Chaperonin complex component, TCP-1 delta subunit (CCT4) Cluster-8309.35241 BF_2 368.66 13.45 1434 91078908 XP_967303.1 743 6.5e-76 PREDICTED: U1 small nuclear ribonucleoprotein 70 kDa [Tribolium castaneum]>gi|270003669|gb|EFA00117.1| hypothetical protein TcasGA2_TC002933 [Tribolium castaneum] 766937927 XM_011503139.1 112 3.52024e-49 PREDICTED: Ceratosolen solmsi marchali U1 small nuclear ribonucleoprotein 70 kDa-like (LOC105365059), mRNA K11093 SNRP70 U1 small nuclear ribonucleoprotein 70kDa http://www.genome.jp/dbget-bin/www_bget?ko:K11093 P17133 635 8.9e-65 U1 small nuclear ribonucleoprotein 70 kDa OS=Drosophila melanogaster GN=snRNP-U1-70K PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0097159//GO:0003676//GO:1901363 organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.35242 BF_2 92.39 0.64 6360 642917972 XP_008198965.1 2821 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X3 [Tribolium castaneum] 157125487 XM_001654304.1 70 3.54059e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 2265 3.9e-253 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01593//PF00070//PF07992//PF01180 Flavin containing amine oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Dihydroorotate dehydrogenase GO:0055114 oxidation-reduction process GO:0016627//GO:0016491 oxidoreductase activity, acting on the CH-CH group of donors//oxidoreductase activity GO:0005737 cytoplasm KOG0399 Glutamate synthase Cluster-8309.35243 BF_2 448.00 36.54 800 642927327 XP_008195222.1 560 6.0e-55 PREDICTED: protein canopy homolog 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXT0 247 4.9e-20 Protein canopy homolog 2 OS=Mus musculus GN=Cnpy2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3782 Predicted membrane protein, contains type II SA sequence Cluster-8309.35244 BF_2 1136.74 9.54 5274 642930359 XP_008196365.1 725 2.9e-73 PREDICTED: protein DEK isoform X1 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.71562e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.35245 BF_2 1727.74 12.19 6217 546682799 ERL92688.1 323 1.4e-26 hypothetical protein D910_09999 [Dendroctonus ponderosae] -- -- -- -- -- K13189 RBM14 RNA-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13189 Q96PK6 166 9.4e-10 RNA-binding protein 14 OS=Homo sapiens GN=RBM14 PE=1 SV=2 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.35246 BF_2 36.45 0.44 3761 805752828 XP_012154051.1 2799 0.0e+00 PREDICTED: alpha-actinin, sarcomeric isoform X2 [Megachile rotundata] 755976945 XM_011309818.1 574 0 PREDICTED: Fopius arisanus alpha-actinin, sarcomeric (LOC105269505), transcript variant X2, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 2717 8.9e-306 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 PF00435//PF00036//PF13833//PF13405//PF13499//PF13202//PF00307 Spectrin repeat//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Calponin homology (CH) domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.35248 BF_2 12.75 0.44 1494 642933931 XP_008197572.1 565 3.0e-55 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 233 3.8e-18 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35249 BF_2 31.02 0.58 2534 270010086 EFA06534.1 365 7.8e-32 hypothetical protein TcasGA2_TC009438 [Tribolium castaneum] 565446497 XM_006284601.1 38 8.60783e-08 Capsella rubella hypothetical protein (CARUB_v10005922mg) mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 Q9XSU4 349 2.3e-31 40S ribosomal protein S11 OS=Canis familiaris GN=RPS11 PE=1 SV=2 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.35250 BF_2 859.02 35.58 1297 478255948 ENN76149.1 612 9.1e-61 hypothetical protein YQE_07321, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35252 BF_2 3429.72 202.41 996 642914876 XP_008190427.1 634 2.0e-63 PREDICTED: tropomyosin alpha-1 chain [Tribolium castaneum]>gi|270001406|gb|EEZ97853.1| hypothetical protein TcasGA2_TC000225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O67124 133 1.0e-06 Probable DNA double-strand break repair Rad50 ATPase OS=Aquifex aeolicus (strain VF5) GN=rad50 PE=3 SV=1 PF08702//PF03936//PF06009 Fibrinogen alpha/beta chain family//Terpene synthase family, metal binding domain//Laminin Domain II GO:0007155//GO:0030168//GO:0051258//GO:0007165 cell adhesion//platelet activation//protein polymerization//signal transduction GO:0010333//GO:0016829//GO:0000287//GO:0030674//GO:0005102 terpene synthase activity//lyase activity//magnesium ion binding//protein binding, bridging//receptor binding GO:0005577 fibrinogen complex -- -- Cluster-8309.35253 BF_2 3594.26 25.63 6154 642928768 XP_008195553.1 4946 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 342356458 JF265057.1 79 3.40272e-30 Heliconius melpomene cythera ribosomal protein L29 (RpL29) mRNA, complete cds K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3572 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF00122//PF10473//PF01779 E1-E2 ATPase//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008134//GO:0045502//GO:0003735//GO:0042803//GO:0000166//GO:0046872 transcription factor binding//dynein binding//structural constituent of ribosome//protein homodimerization activity//nucleotide binding//metal ion binding GO:0030286//GO:0005667//GO:0005840//GO:0005622 dynein complex//transcription factor complex//ribosome//intracellular KOG0210 P-type ATPase Cluster-8309.35255 BF_2 45.38 1.11 1992 270013360 EFA09808.1 1271 5.4e-137 hypothetical protein TcasGA2_TC011953 [Tribolium castaneum] -- -- -- -- -- K18624 MAEA, EMP macrophage erythroblast attacher http://www.genome.jp/dbget-bin/www_bget?ko:K18624 Q6GR10 861 7.7e-91 Macrophage erythroblast attacher OS=Xenopus laevis GN=maea PE=2 SV=2 PF06291//PF08513 Bor protein//LisH -- -- GO:0005515 protein binding GO:0009279 cell outer membrane KOG0396 Uncharacterized conserved protein Cluster-8309.35258 BF_2 2628.01 70.80 1840 642911947 XP_008199033.1 1184 6.1e-127 PREDICTED: phospholipid scramblase 2 isoform X1 [Tribolium castaneum] 462310482 APGK01047306.1 73 2.17376e-27 Dendroctonus ponderosae Seq01047316, whole genome shotgun sequence -- -- -- -- O15162 796 2.5e-83 Phospholipid scramblase 1 OS=Homo sapiens GN=PLSCR1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0621 Phospholipid scramblase Cluster-8309.35259 BF_2 1496.72 34.40 2107 91084421 XP_968215.1 1625 5.1e-178 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 980 1.3e-104 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326//PF06467 alpha/beta hydrolase fold//Prolyl oligopeptidase family//MYM-type Zinc finger with FCS sequence motif GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008270//GO:0016787//GO:0008236 zinc ion binding//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.35261 BF_2 209.84 2.72 3516 642930868 XP_008196118.1 1543 2.7e-168 PREDICTED: homeobox protein PKNOX2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96KN3 713 2.0e-73 Homeobox protein PKNOX2 OS=Homo sapiens GN=PKNOX2 PE=2 SV=2 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.35262 BF_2 1870.19 86.18 1195 270014475 EFA10923.1 726 5.1e-74 hypothetical protein TcasGA2_TC001749 [Tribolium castaneum] -- -- -- -- -- K15410 EEF1D elongation factor 1-delta http://www.genome.jp/dbget-bin/www_bget?ko:K15410 Q9VL18 494 1.7e-48 Probable elongation factor 1-delta OS=Drosophila melanogaster GN=eEF1delta PE=1 SV=1 PF00736//PF00958//PF08702//PF02346//PF10152//PF06009 EF-1 guanine nucleotide exchange domain//GMP synthase C terminal domain//Fibrinogen alpha/beta chain family//Chordopoxvirus multifunctional envelope protein A27//Predicted coiled-coil domain-containing protein (DUF2360)//Laminin Domain II GO:0030168//GO:0007155//GO:0019064//GO:0006144//GO:0006177//GO:0006414//GO:0007165//GO:0006536//GO:0006448//GO:0051258//GO:0006164 platelet activation//cell adhesion//fusion of virus membrane with host plasma membrane//purine nucleobase metabolic process//GMP biosynthetic process//translational elongation//signal transduction//glutamate metabolic process//regulation of translational elongation//protein polymerization//purine nucleotide biosynthetic process GO:0003922//GO:0003746//GO:0030674//GO:0005102//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//translation elongation factor activity//protein binding, bridging//receptor binding//ATP binding GO:0005853//GO:0019031//GO:0005840//GO:0005577//GO:0071203 eukaryotic translation elongation factor 1 complex//viral envelope//ribosome//fibrinogen complex//WASH complex KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.35263 BF_2 66.15 18.65 435 264667463 ACY71317.1 400 1.2e-36 ribosomal protein L22 [Chrysomela tremula] -- -- -- -- -- K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 233 1.1e-18 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3434 60S ribosomal protein L22 Cluster-8309.35266 BF_2 69.84 10.04 578 91090912 XP_973979.1 533 5.9e-52 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] 642936036 XM_968886.2 117 2.27512e-52 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47948 487 5.2e-48 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF12763//PF13202//PF13499//PF00036//PF13833//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35267 BF_2 16.96 0.78 1199 91077036 XP_967646.1 369 1.3e-32 PREDICTED: molybdenum cofactor sulfurase 1 [Tribolium castaneum]>gi|270001749|gb|EEZ98196.1| hypothetical protein TcasGA2_TC000626 [Tribolium castaneum] -- -- -- -- -- K15631 ABA3 molybdenum cofactor sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15631 Q8IU29 250 3.3e-20 Molybdenum cofactor sulfurase OS=Bombyx mori GN=mal PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35268 BF_2 9.61 52.63 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06872 EspG protein GO:0006508//GO:0009405 proteolysis//pathogenesis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.35271 BF_2 1231.64 123.90 703 91091878 XP_969758.1 559 6.9e-55 PREDICTED: von Willebrand factor D and EGF domain-containing protein [Tribolium castaneum]>gi|270001301|gb|EEZ97748.1| nimrod B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N2E2 169 4.8e-11 von Willebrand factor D and EGF domain-containing protein OS=Homo sapiens GN=VWDE PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35272 BF_2 871.00 46.66 1068 91080521 XP_971959.1 1127 1.4e-120 PREDICTED: 26S proteasome non-ATPase regulatory subunit 8 [Tribolium castaneum]>gi|270005781|gb|EFA02229.1| hypothetical protein TcasGA2_TC007891 [Tribolium castaneum] -- -- -- -- -- K03031 PSMD8, RPN12 26S proteasome regulatory subunit N12 http://www.genome.jp/dbget-bin/www_bget?ko:K03031 Q9CX56 784 3.5e-82 26S proteasome non-ATPase regulatory subunit 8 OS=Mus musculus GN=Psmd8 PE=1 SV=2 -- -- GO:0006508 proteolysis -- -- GO:0005838 proteasome regulatory particle KOG3151 26S proteasome regulatory complex, subunit RPN12/PSMD8 Cluster-8309.35274 BF_2 144.57 3.15 2208 642934520 XP_001812516.2 603 1.7e-59 PREDICTED: tetraspanin-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.35275 BF_2 41.19 0.90 2209 91084421 XP_968215.1 1568 2.2e-171 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 889 4.9e-94 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF06467//PF07859//PF00326 MYM-type Zinc finger with FCS sequence motif//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008270//GO:0008236 hydrolase activity//zinc ion binding//serine-type peptidase activity -- -- -- -- Cluster-8309.35276 BF_2 522.98 21.35 1312 91086095 XP_967348.1 1672 1.1e-183 PREDICTED: tubulin beta chain [Tribolium castaneum]>gi|270010216|gb|EFA06664.1| hypothetical protein TcasGA2_TC009590 [Tribolium castaneum] 571525023 XM_394469.4 429 0 PREDICTED: Apis mellifera beta-Tubulin at 60D ortholog (LOC410994), transcript variant 2, mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 P08841 1594 5.1e-176 Tubulin beta-3 chain OS=Drosophila melanogaster GN=betaTub60D PE=2 SV=2 PF00091 Tubulin/FtsZ family, GTPase domain GO:0006184//GO:0007018//GO:0051258 obsolete GTP catabolic process//microtubule-based movement//protein polymerization GO:0005525//GO:0005198//GO:0003924 GTP binding//structural molecule activity//GTPase activity GO:0005737//GO:0005874 cytoplasm//microtubule KOG1375 Beta tubulin Cluster-8309.35277 BF_2 1680.52 77.10 1199 815806339 XP_012223941.1 578 7.4e-57 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105673125 [Linepithema humile] 642916990 XM_967678.2 232 5.74215e-116 PREDICTED: Tribolium castaneum protein translation factor SUI1 homolog (LOC661525), mRNA K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 P42678 546 1.6e-54 Protein translation factor SUI1 homolog OS=Anopheles gambiae GN=AGAP006459 PE=3 SV=1 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-8309.35278 BF_2 53.44 2.39 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35279 BF_2 182.42 7.16 1353 642928322 XP_008195533.1 577 1.1e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.0e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.35284 BF_2 437.00 6.48 3108 332375280 AEE62781.1 763 6.8e-78 unknown [Dendroctonus ponderosae]>gi|478256834|gb|ENN77009.1| hypothetical protein YQE_06503, partial [Dendroctonus ponderosae] 642913881 XM_970098.2 182 9.44612e-88 PREDICTED: Tribolium castaneum dnaJ homolog subfamily C member 8 (LOC664081), mRNA K09528 DNAJC8 DnaJ homolog subfamily C member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09528 Q6NZB0 496 2.5e-48 DnaJ homolog subfamily C member 8 OS=Mus musculus GN=Dnajc8 PE=2 SV=2 PF12537//PF06963 The Golgi pH Regulator (GPHR) Family N-terminal//Ferroportin1 (FPN1) GO:0006826//GO:0034755 iron ion transport//iron ion transmembrane transport GO:0005381 iron ion transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1150 Predicted molecular chaperone (DnaJ superfamily) Cluster-8309.35285 BF_2 2103.00 34.73 2820 642918411 XP_008191461.1 3094 0.0e+00 PREDICTED: AFG3-like protein 2 [Tribolium castaneum]>gi|270003255|gb|EEZ99702.1| hypothetical protein TcasGA2_TC002463 [Tribolium castaneum] 815902633 XM_003487018.2 362 0 PREDICTED: Bombus impatiens AFG3-like protein 2 (LOC100740165), mRNA K08956 AFG3 AFG3 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K08956 Q9Y4W6 2279 4.1e-255 AFG3-like protein 2 OS=Homo sapiens GN=AFG3L2 PE=1 SV=2 PF01695//PF07728//PF05496//PF06480//PF06068//PF00004//PF01434//PF07724 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//FtsH Extracellular//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Peptidase family M41//AAA domain (Cdc48 subfamily) GO:0030163//GO:0006508//GO:0006310//GO:0006281 protein catabolic process//proteolysis//DNA recombination//DNA repair GO:0017111//GO:0009378//GO:0016887//GO:0008270//GO:0003678//GO:0005524//GO:0004222 nucleoside-triphosphatase activity//four-way junction helicase activity//ATPase activity//zinc ion binding//DNA helicase activity//ATP binding//metalloendopeptidase activity GO:0016021//GO:0009379//GO:0005657 integral component of membrane//Holliday junction helicase complex//replication fork KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.35286 BF_2 788.15 23.96 1663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF08119 Arthropod defensin//Scorpion acidic alpha-KTx toxin family GO:0006952//GO:0006810//GO:0009405 defense response//transport//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.35287 BF_2 5040.63 432.23 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02788 Ribulose bisphosphate carboxylase large chain, N-terminal domain GO:0015977//GO:0046487 carbon fixation//glyoxylate metabolic process GO:0016984 ribulose-bisphosphate carboxylase activity GO:0009573 chloroplast ribulose bisphosphate carboxylase complex -- -- Cluster-8309.35288 BF_2 2779.42 15.09 7993 91084687 XP_968830.1 2631 4.3e-294 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] 831284033 XM_012817767.1 98 1.21264e-40 PREDICTED: Clupea harengus myotubularin-related protein 3-like (LOC105891591), mRNA K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q13615 1526 2.4e-167 Myotubularin-related protein 3 OS=Homo sapiens GN=MTMR3 PE=1 SV=3 PF00400//PF07646//PF10716//PF00782//PF01363//PF00102 WD domain, G-beta repeat//Kelch motif//NADH dehydrogenase transmembrane subunit//Dual specificity phosphatase, catalytic domain//FYVE zinc finger//Protein-tyrosine phosphatase GO:0006570//GO:0006470//GO:0006118//GO:0035335//GO:0055114 tyrosine metabolic process//protein dephosphorylation//obsolete electron transport//peptidyl-tyrosine dephosphorylation//oxidation-reduction process GO:0004725//GO:0008138//GO:0005515//GO:0046872//GO:0016655 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//metal ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.35290 BF_2 978.00 14.08 3192 73921480 AAZ94270.1 1338 1.5e-144 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 902 2.2e-95 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0016705//GO:0005488 heme binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.35291 BF_2 19.48 0.40 2316 91090182 XP_966481.1 1041 2.9e-110 PREDICTED: methenyltetrahydrofolate synthase domain-containing protein [Tribolium castaneum]>gi|270013764|gb|EFA10212.1| hypothetical protein TcasGA2_TC012407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M296 578 5.9e-58 Methenyltetrahydrofolate synthase domain-containing protein OS=Homo sapiens GN=MTHFSD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4410 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.35292 BF_2 26779.88 562.99 2277 282848147 NP_001164292.1 1039 4.9e-110 kayak isoform A [Tribolium castaneum]>gi|270014251|gb|EFA10699.1| kayak [Tribolium castaneum] -- -- -- -- -- K09031 FOSLN fos-like antigen, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09031 B4K617 198 6.7e-14 Transcription factor kayak OS=Drosophila mojavensis GN=kay PE=3 SV=1 PF00170//PF07716//PF03131 bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.35293 BF_2 987.86 4.87 8776 270003498 EEZ99945.1 2824 0.0e+00 hypothetical protein TcasGA2_TC002741 [Tribolium castaneum] -- -- -- -- -- K12316 GAA lysosomal alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12316 Q6P7A9 1834 5.1e-203 Lysosomal alpha-glucosidase OS=Rattus norvegicus GN=Gaa PE=2 SV=1 PF13465//PF00096//PF01055//PF02892//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Glycosyl hydrolases family 31//BED zinc finger//C2H2-type zinc finger GO:0005975 carbohydrate metabolic process GO:0046872//GO:0004553//GO:0003677 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding -- -- -- -- Cluster-8309.35294 BF_2 10017.91 1106.15 666 264667421 ACY71296.1 1011 2.5e-107 ribosomal protein L13A [Chrysomela tremula] -- -- -- -- -- K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 Q962U0 866 6.8e-92 60S ribosomal protein L13a OS=Spodoptera frugiperda GN=RpL13A PE=2 SV=1 PF00707//PF00572 Translation initiation factor IF-3, C-terminal domain//Ribosomal protein L13 GO:0042254//GO:0006412//GO:0006413 ribosome biogenesis//translation//translational initiation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-8309.35296 BF_2 343.67 5.69 2816 642914766 XP_008190343.1 509 1.7e-48 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N2D1 239 1.5e-18 Tryptase OS=Sus scrofa GN=MCT7 PE=2 SV=1 PF00089//PF00647//PF03609 Trypsin//Elongation factor 1 gamma, conserved domain//PTS system sorbose-specific iic component GO:0006414//GO:0006448//GO:0009401//GO:0006508 translational elongation//regulation of translational elongation//phosphoenolpyruvate-dependent sugar phosphotransferase system//proteolysis GO:0003746//GO:0004252 translation elongation factor activity//serine-type endopeptidase activity GO:0016021//GO:0005840 integral component of membrane//ribosome -- -- Cluster-8309.35297 BF_2 1667.60 225.85 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35298 BF_2 6284.04 163.39 1896 270013857 EFA10305.1 208 9.4e-14 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35299 BF_2 629.00 15.41 1995 546679644 ERL90075.1 699 1.1e-70 hypothetical protein D910_07430, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPK7 278 3.1e-23 Lateral signaling target protein 2 homolog OS=Mus musculus GN=Zfyve28 PE=1 SV=2 PF07127//PF00643//PF01363//PF16622//PF00320 Late nodulin protein//B-box zinc finger//FYVE zinc finger//zinc-finger C2H2-type//GATA zinc finger GO:0006355//GO:0009878 regulation of transcription, DNA-templated//nodule morphogenesis GO:0043565//GO:0008270//GO:0003700//GO:0046872 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.35301 BF_2 1501.67 96.08 941 288860140 NP_001165842.1 638 6.4e-64 uracil-DNA degrading factor [Tribolium castaneum]>gi|270002992|gb|EEZ99439.1| hypothetical protein TcasGA2_TC030651 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35302 BF_2 37.24 3.05 798 332374126 AEE62204.1 764 1.3e-78 unknown [Dendroctonus ponderosae]>gi|478256630|gb|ENN76812.1| hypothetical protein YQE_06653, partial [Dendroctonus ponderosae]>gi|546685174|gb|ERL94701.1| hypothetical protein D910_11975 [Dendroctonus ponderosae] -- -- -- -- -- K10258 TER, TSC13, CER10 very-long-chain enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10258 Q9N5Y2 641 1.0e-65 Probable very-long-chain enoyl-CoA reductase art-1 OS=Caenorhabditis elegans GN=art-1 PE=3 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1639 Steroid reductase required for elongation of the very long chain fatty acids Cluster-8309.35305 BF_2 1669.79 11.57 6323 642918534 XP_008191512.1 3637 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7P4 637 2.3e-64 SEC14 domain and spectrin repeat-containing protein 1 OS=Xenopus tropicalis GN=sestd1 PE=2 SV=1 PF00435//PF00260//PF00536 Spectrin repeat//Protamine P1//SAM domain (Sterile alpha motif) GO:0007283 spermatogenesis GO:0003677//GO:0005515 DNA binding//protein binding GO:0000786//GO:0005634 nucleosome//nucleus KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.35307 BF_2 25.77 2.72 684 258643293 ACV86033.1 164 4.3e-09 neuropeptide F [Reticulitermes flavipes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35309 BF_2 10171.00 873.95 774 264667423 ACY71297.1 979 1.5e-103 ribosomal protein L13 [Chrysomela tremula] 332373967 BT127163.1 183 6.33052e-89 Dendroctonus ponderosae clone DPO0813_M04 unknown mRNA K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 Q962U1 810 2.5e-85 60S ribosomal protein L13 OS=Spodoptera frugiperda GN=RpL13 PE=2 SV=1 PF01294 Ribosomal protein L13e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3295 60S Ribosomal protein L13 Cluster-8309.35310 BF_2 66227.11 3603.42 1056 91076896 XP_976237.1 1203 2.2e-129 PREDICTED: troponin T, skeletal muscle isoform X1 [Tribolium castaneum] 459668605 JX303047.1 36 4.55521e-07 Lutzomyia longipalpis isolate PanupC10 up (up) gene, partial cds >gnl|BL_ORD_ID|16415056 Lutzomyia longipalpis isolate PanupH11 up (up) gene, partial cds K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 P19351 1008 3.7e-108 Troponin T, skeletal muscle OS=Drosophila melanogaster GN=up PE=1 SV=3 PF00769//PF00992 Ezrin/radixin/moesin family//Troponin -- -- GO:0008092 cytoskeletal protein binding GO:0005737//GO:0005861//GO:0019898 cytoplasm//troponin complex//extrinsic component of membrane KOG3634 Troponin Cluster-8309.35311 BF_2 380.00 9.13 2028 91090696 XP_974756.1 1055 6.1e-112 PREDICTED: transmembrane emp24 domain-containing protein A [Tribolium castaneum]>gi|270013945|gb|EFA10393.1| hypothetical protein TcasGA2_TC012624 [Tribolium castaneum] 755957621 XM_011305512.1 75 1.85544e-28 PREDICTED: Fopius arisanus transmembrane emp24 domain-containing protein 1 (LOC105266973), mRNA -- -- -- -- Q9CXE7 228 2.0e-17 Transmembrane emp24 domain-containing protein 5 OS=Mus musculus GN=Tmed5 PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.35316 BF_2 2017.45 13.87 6374 642939200 XP_008200378.1 588 2.7e-57 PREDICTED: plasminogen activator inhibitor 1 RNA-binding protein-like, partial [Tribolium castaneum] 642933104 XM_008199038.1 222 1.13162e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 185 6.0e-12 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006560//GO:0006420//GO:0006525 proline metabolic process//arginyl-tRNA aminoacylation//arginine metabolic process GO:0004814//GO:0000166//GO:0005524 arginine-tRNA ligase activity//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG2945 Predicted RNA-binding protein Cluster-8309.35319 BF_2 2358.30 48.03 2341 91079178 XP_966498.1 760 1.1e-77 PREDICTED: vesicle-associated membrane protein-associated protein B [Tribolium castaneum]>gi|270003608|gb|EFA00056.1| hypothetical protein TcasGA2_TC002864 [Tribolium castaneum] 642916508 XM_961405.2 63 1.00592e-21 PREDICTED: Tribolium castaneum vesicle-associated membrane protein-associated protein B (LOC656484), mRNA K06096 VAPA vesicle-associated membrane protein-associated protein A http://www.genome.jp/dbget-bin/www_bget?ko:K06096 Q5R601 430 8.6e-41 Vesicle-associated membrane protein-associated protein A OS=Pongo abelii GN=VAPA PE=2 SV=2 PF00170//PF07716//PF08172//PF06005//PF06156//PF04111//PF04977 bZIP transcription factor//Basic region leucine zipper//CASP C terminal//Protein of unknown function (DUF904)//Protein of unknown function (DUF972)//Autophagy protein Apg6//Septum formation initiator GO:0006891//GO:0006914//GO:0006260//GO:0006355//GO:0043093//GO:0000917//GO:0007049 intra-Golgi vesicle-mediated transport//autophagy//DNA replication//regulation of transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0030173//GO:0005737 transcription factor complex//integral component of Golgi membrane//cytoplasm KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-8309.35320 BF_2 22.00 2.57 645 675368640 KFM61542.1 755 1.2e-77 60S ribosomal protein L13a, partial [Stegodyphus mimosarum] 264667056 FJ790491.1 216 2.36401e-107 Scylla paramamosain 60S ribosomal protein L13A mRNA, partial cds K02872 RP-L13Ae, RPL13A large subunit ribosomal protein L13Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02872 Q8MUR4 679 3.2e-70 60S ribosomal protein L13a OS=Choristoneura parallela GN=RpL13A PE=2 SV=1 PF00572 Ribosomal protein L13 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3204 60S ribosomal protein L13a Cluster-8309.35322 BF_2 424.00 10.86 1920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35323 BF_2 7599.50 1465.13 504 91094863 XP_972456.1 324 8.8e-28 PREDICTED: 60S acidic ribosomal protein P1 [Tribolium castaneum]>gi|270006544|gb|EFA02992.1| hypothetical protein TcasGA2_TC010413 [Tribolium castaneum] 642922948 XM_967363.3 121 1.17754e-54 PREDICTED: Tribolium castaneum 60S acidic ribosomal protein P1 (LOC661185), mRNA K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P08570 303 9.9e-27 60S acidic ribosomal protein P1 OS=Drosophila melanogaster GN=RpLP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.35325 BF_2 1493.33 5.64 11371 642933491 XP_008197440.1 3273 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 211 2.63674e-103 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1887 4.7e-209 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0008152 metabolic process GO:0003824//GO:0019843//GO:0003723 catalytic activity//rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.35326 BF_2 1043.36 19.53 2522 270004278 EFA00726.1 492 1.5e-46 hypothetical protein TcasGA2_TC003607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35327 BF_2 59.62 0.95 2912 642916650 XP_008192038.1 492 1.7e-46 PREDICTED: uncharacterized protein LOC103312652 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35328 BF_2 482.81 6.99 3177 270001643 EEZ98090.1 515 4.0e-49 hypothetical protein TcasGA2_TC000503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01290//PF16074 Thymosin beta-4 family//Type IV Pilus-assembly protein W GO:0007015//GO:0043683 actin filament organization//type IV pilus biogenesis GO:0003785 actin monomer binding -- -- KOG4794 Thymosin beta Cluster-8309.35329 BF_2 19.43 0.38 2426 91091864 XP_968949.1 505 4.4e-48 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [Tribolium castaneum]>gi|270001295|gb|EEZ97742.1| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 [Tribolium castaneum] -- -- -- -- -- K03964 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03964 Q02372 211 2.2e-15 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Bos taurus GN=NDUFB8 PE=1 SV=1 PF04839//PF05821 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)//NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) GO:0015992//GO:0042254//GO:0006814//GO:0006118//GO:0006744//GO:0006412//GO:0006120 proton transport//ribosome biogenesis//sodium ion transport//obsolete electron transport//ubiquinone biosynthetic process//translation//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003735//GO:0003954 NADH dehydrogenase (ubiquinone) activity//structural constituent of ribosome//NADH dehydrogenase activity GO:0005739//GO:0005840 mitochondrion//ribosome -- -- Cluster-8309.35330 BF_2 187.96 5.23 1790 91091864 XP_968949.1 505 3.2e-48 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [Tribolium castaneum]>gi|270001295|gb|EEZ97742.1| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 [Tribolium castaneum] -- -- -- -- -- K03964 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03964 Q02372 211 1.6e-15 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Bos taurus GN=NDUFB8 PE=1 SV=1 PF05821//PF04839 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8)//Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) GO:0006120//GO:0006412//GO:0006744//GO:0006118//GO:0006814//GO:0042254//GO:0015992 mitochondrial electron transport, NADH to ubiquinone//translation//ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//ribosome biogenesis//proton transport GO:0003954//GO:0003735//GO:0008137 NADH dehydrogenase activity//structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity GO:0005840//GO:0005739 ribosome//mitochondrion -- -- Cluster-8309.35331 BF_2 121.25 0.64 8185 270006717 EFA03165.1 2578 6.2e-288 hypothetical protein TcasGA2_TC013085 [Tribolium castaneum] 642924726 XM_008196195.1 59 5.94388e-19 PREDICTED: Tribolium castaneum RB1-inducible coiled-coil protein 1 (LOC663996), transcript variant X7, mRNA K17589 RB1CC1 RB1-inducible coiled-coil protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17589 Q9HC24 552 2.1e-54 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.35333 BF_2 440.72 5.38 3711 642919693 XP_008192024.1 1421 4.1e-154 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 597 5.9e-60 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF00520//PF00023//PF10716//PF13606 Ion transport protein//Ankyrin repeat//NADH dehydrogenase transmembrane subunit//Ankyrin repeat GO:0006118//GO:0006811//GO:0055114//GO:0055085 obsolete electron transport//ion transport//oxidation-reduction process//transmembrane transport GO:0005216//GO:0016655//GO:0005515 ion channel activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//protein binding GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.35334 BF_2 1564.14 25.27 2876 478262395 ENN81066.1 2644 4.8e-296 hypothetical protein YQE_02435, partial [Dendroctonus ponderosae]>gi|546673615|gb|ERL85179.1| hypothetical protein D910_02601 [Dendroctonus ponderosae] 807040070 XM_004535125.2 159 5.33065e-75 PREDICTED: Ceratitis capitata plastin-3 (LOC101457045), transcript variant X2, mRNA K17336 PLS3 plastin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K17336 P13796 1474 9.2e-162 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=6 PF13499//PF13833//PF00036//PF13405//PF00307//PF04608//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Calponin homology (CH) domain//Phosphatidylglycerophosphatase A//EF hand GO:0006629//GO:0046486 lipid metabolic process//glycerolipid metabolic process GO:0008962//GO:0005515//GO:0005509 phosphatidylglycerophosphatase activity//protein binding//calcium ion binding -- -- KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Cluster-8309.35335 BF_2 300.17 2.08 6321 642912779 XP_008201247.1 4231 0.0e+00 PREDICTED: chaoptin isoform X1 [Tribolium castaneum] 759065584 XM_011343927.1 47 2.14792e-12 PREDICTED: Cerapachys biroi homeobox protein Hox-B1a-like (LOC105282160), mRNA -- -- -- -- P12024 3007 0.0e+00 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00046//PF13855//PF00560 Homeobox domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.35337 BF_2 45.84 6.35 589 91078888 XP_973143.1 409 1.4e-37 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 O55173 294 1.3e-25 3-phosphoinositide-dependent protein kinase 1 OS=Rattus norvegicus GN=Pdpk1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.35338 BF_2 21.21 0.31 3121 91078888 XP_973143.1 1226 1.4e-131 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 Q9Z2A0 831 3.6e-87 3-phosphoinositide-dependent protein kinase 1 OS=Mus musculus GN=Pdpk1 PE=1 SV=2 PF06293//PF00069//PF07714//PF05445 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004674//GO:0004672//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.35339 BF_2 22.91 0.89 1366 91090290 XP_971485.1 939 1.2e-98 PREDICTED: bax inhibitor 1 [Tribolium castaneum]>gi|270013796|gb|EFA10244.1| hypothetical protein TcasGA2_TC012443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7R1 567 6.5e-57 Bax inhibitor 1 OS=Pongo abelii GN=TMBIM6 PE=2 SV=2 -- -- GO:0043066 negative regulation of apoptotic process -- -- GO:0016021 integral component of membrane KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-8309.35340 BF_2 10.21 0.34 1536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.35341 BF_2 27.47 0.98 1457 189237643 XP_966949.2 744 5.1e-76 PREDICTED: diphthine synthase [Tribolium castaneum] -- -- -- -- -- K00586 DPH5 diphthine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00586 Q9H2P9 611 5.5e-62 Diphthine methyl ester synthase OS=Homo sapiens GN=DPH5 PE=1 SV=2 PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG3123 Diphthine synthase Cluster-8309.35345 BF_2 421.45 12.05 1750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35346 BF_2 844.44 12.20 3183 149588751 NP_001092296.1 2699 2.2e-302 fused lobes [Tribolium castaneum]>gi|642928772|ref|XP_008195555.1| PREDICTED: fused lobes isoform X1 [Tribolium castaneum]>gi|148611482|gb|ABQ95985.1| beta-N-acetylglucosaminidase FDL [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 1351 1.9e-147 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975//GO:0006027//GO:0001575//GO:0006040 carbohydrate metabolic process//glycosaminoglycan catabolic process//globoside metabolic process//amino sugar metabolic process GO:0004563//GO:0004553//GO:0043169 beta-N-acetylhexosaminidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.35347 BF_2 3121.48 43.91 3261 589060796 AHK26791.1 476 1.4e-44 eukaryotic translation initiation factor 4A [Epicauta chinensis] 630969033 XM_007882734.1 83 1.07191e-32 Pseudozyma flocculosa PF-1 hypothetical protein partial mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 P29562 433 5.4e-41 Eukaryotic initiation factor 4A-I (Fragment) OS=Oryctolagus cuniculus GN=EIF4A1 PE=1 SV=2 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.35348 BF_2 3013.00 220.03 860 332372622 AEE61453.1 460 2.5e-43 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P82120 144 4.6e-08 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.35349 BF_2 180.42 4.23 2073 642912671 XP_969018.2 1631 1.0e-178 PREDICTED: acyloxyacyl hydrolase [Tribolium castaneum] -- -- -- -- -- K01065 AOAH acyloxyacyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01065 P28039 1000 6.1e-107 Acyloxyacyl hydrolase OS=Homo sapiens GN=AOAH PE=1 SV=1 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.35350 BF_2 1658.85 32.64 2413 282165788 NP_001164133.1 1259 1.6e-135 scavenger receptor protein [Tribolium castaneum]>gi|270009221|gb|EFA05669.1| hypothetical protein TcasGA2_TC014951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61009 503 3.0e-49 Scavenger receptor class B member 1 OS=Mus musculus GN=Scarb1 PE=1 SV=1 PF01130//PF04790 CD36 family//Sarcoglycan complex subunit protein GO:0007155 cell adhesion -- -- GO:0016020//GO:0016021//GO:0016012 membrane//integral component of membrane//sarcoglycan complex -- -- Cluster-8309.35352 BF_2 1443.46 37.42 1901 817216800 XP_012284405.1 719 5.2e-73 PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus]>gi|817216802|ref|XP_012284407.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Orussus abietinus] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 Q9TU03 480 1.1e-46 Rho GDP-dissociation inhibitor 2 OS=Bos taurus GN=ARHGDIB PE=2 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.35355 BF_2 73.42 0.75 4365 157111458 XP_001651573.1 1004 1.1e-105 AAEL005895-PA [Aedes aegypti]>gi|108878342|gb|EAT42567.1| AAEL005895-PA [Aedes aegypti] 462380259 APGK01022394.1 40 1.15235e-08 Dendroctonus ponderosae Seq01022404, whole genome shotgun sequence K04520 APP amyloid beta A4 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04520 P14599 928 2.9e-98 Beta-amyloid-like protein OS=Drosophila melanogaster GN=Appl PE=1 SV=2 PF02177//PF12924 Amyloid A4 N-terminal heparin-binding//Copper-binding of amyloid precursor, CuBD -- -- GO:0046914//GO:0008201 transition metal ion binding//heparin binding GO:0016021 integral component of membrane KOG3540 Beta amyloid precursor protein Cluster-8309.35356 BF_2 30.47 19.40 348 343129408 AEL88545.1 162 3.7e-09 cytochrome P450 CYP4G56v1 [Dendroctonus rhizophagus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35357 BF_2 1921.48 38.22 2390 642915594 XP_008190680.1 1174 1.1e-125 PREDICTED: uncharacterized protein LOC655748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35358 BF_2 1699.93 26.31 2990 642926574 XP_008194926.1 2179 4.2e-242 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] 826494758 XM_012685372.1 98 4.50386e-41 PREDICTED: Monomorium pharaonis scavenger receptor class B member 1 (LOC105839216), mRNA -- -- -- -- O18824 708 6.4e-73 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.35359 BF_2 337.85 1.35 10738 642935263 XP_008197938.1 6738 0.0e+00 PREDICTED: hemocytin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98092 3367 0.0e+00 Hemocytin OS=Bombyx mori PE=2 SV=1 PF05805//PF11051//PF00093//PF05375 L6 membrane protein//Mannosyltransferase putative//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) GO:0006486 protein glycosylation GO:0016757//GO:0005515//GO:0030414 transferase activity, transferring glycosyl groups//protein binding//peptidase inhibitor activity GO:0016021 integral component of membrane -- -- Cluster-8309.35360 BF_2 31.17 0.31 4532 478251563 ENN72025.1 1955 5.9e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 3.9e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.35361 BF_2 129.75 31.17 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35362 BF_2 149.98 2.99 2384 91079999 XP_966589.1 1804 1.0e-198 PREDICTED: kelch domain-containing protein 4 [Tribolium castaneum]>gi|270003222|gb|EEZ99669.1| hypothetical protein TcasGA2_TC002426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q921I2 1056 2.3e-113 Kelch domain-containing protein 4 OS=Mus musculus GN=Klhdc4 PE=2 SV=2 PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- KOG1230 Protein containing repeated kelch motifs Cluster-8309.35363 BF_2 24.86 2.57 691 270016290 EFA12736.1 180 6.0e-11 hypothetical protein TcasGA2_TC002373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35364 BF_2 105.44 1.55 3133 642918280 XP_008191442.1 3580 0.0e+00 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 195430887 XM_002063444.1 409 0 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 3025 0.0e+00 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 PF13371//PF13374//PF02259//PF00515//PF13414//PF13176//PF13181//PF05009//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.35365 BF_2 1436.17 41.78 1725 270297202 NP_001161902.1 1685 4.6e-185 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 1313 2.6e-143 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.35369 BF_2 1159.68 15.20 3479 189241841 XP_001807104.1 2470 8.7e-276 PREDICTED: sodium/hydrogen exchanger 8 [Tribolium castaneum]>gi|270015694|gb|EFA12142.1| hypothetical protein TcasGA2_TC002289 [Tribolium castaneum] 642937940 XM_001807052.2 559 0 PREDICTED: Tribolium castaneum sodium/hydrogen exchanger 8 (LOC100141996), mRNA K14724 SLC9A8, NHE8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14724 Q5ZJ75 1474 1.1e-161 Sodium/hydrogen exchanger 8 OS=Gallus gallus PE=2 SV=1 PF02615//PF00999 Malate/L-lactate dehydrogenase//Sodium/hydrogen exchanger family GO:0015992//GO:0055114//GO:0006812//GO:0006814//GO:0006885//GO:0008152//GO:0055085 proton transport//oxidation-reduction process//cation transport//sodium ion transport//regulation of pH//metabolic process//transmembrane transport GO:0016491//GO:0015385//GO:0015299 oxidoreductase activity//sodium:proton antiporter activity//solute:proton antiporter activity GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.35370 BF_2 503.00 21.13 1283 478252243 ENN72671.1 1294 7.5e-140 hypothetical protein YQE_10769, partial [Dendroctonus ponderosae]>gi|546675736|gb|ERL86868.1| hypothetical protein D910_04271 [Dendroctonus ponderosae] -- -- -- -- -- K10660 MARCH5 E3 ubiquitin-protein ligase MARCH5 http://www.genome.jp/dbget-bin/www_bget?ko:K10660 Q6GM44 881 2.4e-93 E3 ubiquitin-protein ligase MARCH5 OS=Xenopus laevis GN=march5 PE=2 SV=1 PF12906//PF00628//PF13639 RING-variant domain//PHD-finger//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.35371 BF_2 59.22 2.04 1504 642922826 XP_008193342.1 972 1.9e-102 PREDICTED: rhodopsin, GQ-coupled isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P43119 167 1.7e-10 Prostacyclin receptor OS=Homo sapiens GN=PTGIR PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.35372 BF_2 74.45 5.16 891 346986300 NP_001231307.1 1481 1.1e-161 polyubiquitin-C [Cricetulus griseus]>gi|2627133|dbj|BAA23488.1| polyubiquitin [Cricetulus griseus] 752889465 XM_011264380.1 380 0 PREDICTED: Camponotus floridanus polyubiquitin-C (LOC105255223), mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 1481 4.4e-163 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF14560//PF00240//PF04452 Ubiquitin-like domain//Ubiquitin family//RNA methyltransferase GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35373 BF_2 37.63 0.97 1909 270013993 EFA10441.1 225 1.0e-15 hypothetical protein TcasGA2_TC012686 [Tribolium castaneum] 642935946 XM_008200020.1 74 6.27491e-28 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35374 BF_2 207.16 1.93 4767 91083171 XP_972171.1 2439 4.7e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.4e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF01331//PF00102//PF03919//PF15182//PF00782 mRNA capping enzyme, catalytic domain//Protein-tyrosine phosphatase//mRNA capping enzyme, C-terminal domain//Otospiralin//Dual specificity phosphatase, catalytic domain GO:0035335//GO:0006370//GO:0007605//GO:0006470//GO:0006570//GO:0006397 peptidyl-tyrosine dephosphorylation//7-methylguanosine mRNA capping//sensory perception of sound//protein dephosphorylation//tyrosine metabolic process//mRNA processing GO:0004651//GO:0004725//GO:0004484//GO:0008138 polynucleotide 5'-phosphatase activity//protein tyrosine phosphatase activity//mRNA guanylyltransferase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.35375 BF_2 1468.69 16.47 4018 270012994 EFA09442.1 3262 0.0e+00 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61824 1131 7.7e-122 Disintegrin and metalloproteinase domain-containing protein 12 OS=Mus musculus GN=Adam12 PE=1 SV=2 PF08516//PF07998//PF01421//PF10462//PF06701//PF00413//PF01562 ADAM cysteine-rich//Peptidase family M54//Reprolysin (M12B) family zinc metalloprotease//Peptidase M66//Mib_herc2//Matrixin//Reprolysin family propeptide GO:0006508//GO:0016567 proteolysis//protein ubiquitination GO:0008270//GO:0004222//GO:0004842//GO:0046872 zinc ion binding//metalloendopeptidase activity//ubiquitin-protein transferase activity//metal ion binding GO:0031012 extracellular matrix KOG3607 Meltrins, fertilins and related Zn-dependent metalloproteinases of the ADAMs family Cluster-8309.35376 BF_2 3876.94 11.72 14129 189233641 XP_001814986.1 2409 4.2e-268 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 242018850 XM_002429839.1 113 9.85274e-49 Pediculus humanus corporis nicotinate phosphoribosyltransferase, putative, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2054 2.5e-228 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF13465//PF02749//PF08603//PF13912//PF01213//PF02892//PF00096//PF07776 Zinc-finger double domain//Quinolinate phosphoribosyl transferase, N-terminal domain//Adenylate cyclase associated (CAP) C terminal//C2H2-type zinc finger//Adenylate cyclase associated (CAP) N terminal//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0007010 cytoskeleton organization GO:0008270//GO:0016763//GO:0003677//GO:0003779//GO:0046872 zinc ion binding//transferase activity, transferring pentosyl groups//DNA binding//actin binding//metal ion binding GO:0005634 nucleus KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.35377 BF_2 3257.42 79.74 1996 859132836 AKO63327.1 2080 8.4e-231 S-adenosylhomocysteine hydrolase 1 [Leptinotarsa decemlineata] 751460631 XM_011186787.1 280 2.00699e-142 PREDICTED: Bactrocera cucurbitae adenosylhomocysteinase (LOC105213739), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q27580 1877 1.2e-208 Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=2 SV=2 PF00208//PF05221//PF07992//PF02254//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//S-adenosyl-L-homocysteine hydrolase//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006520//GO:0006555//GO:0055114//GO:0006730//GO:0006813 cellular amino acid metabolic process//methionine metabolic process//oxidation-reduction process//one-carbon metabolic process//potassium ion transport GO:0016491//GO:0004013//GO:0051287 oxidoreductase activity//adenosylhomocysteinase activity//NAD binding -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.35378 BF_2 38.46 0.39 4413 642918838 XP_008191608.1 2788 0.0e+00 PREDICTED: breast carcinoma-amplified sequence 3 homolog isoform X1 [Tribolium castaneum] 642918837 XM_008193386.1 258 7.60049e-130 PREDICTED: Tribolium castaneum breast carcinoma-amplified sequence 3 homolog (LOC661755), transcript variant X1, mRNA -- -- -- -- Q8SY41 1526 1.3e-167 Breast carcinoma-amplified sequence 3 homolog OS=Drosophila melanogaster GN=rudhira PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2109 WD40 repeat protein Cluster-8309.35380 BF_2 257.00 9.25 1450 91081433 XP_973525.1 769 6.3e-79 PREDICTED: zinc finger protein 622 [Tribolium castaneum]>gi|270005162|gb|EFA01610.1| hypothetical protein TcasGA2_TC007176 [Tribolium castaneum] -- -- -- -- -- K14816 REI1 pre-60S factor REI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14816 Q969S3 526 3.9e-52 Zinc finger protein 622 OS=Homo sapiens GN=ZNF622 PE=1 SV=1 PF02892//PF13465//PF00096//PF04988//PF07535 BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//DBF zinc finger -- -- GO:0003676//GO:0003677//GO:0008270//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//metal ion binding GO:0005622//GO:0005634 intracellular//nucleus KOG2785 C2H2-type Zn-finger protein Cluster-8309.35381 BF_2 8.47 0.34 1320 91086693 XP_969563.1 484 6.5e-46 PREDICTED: 12 kDa FK506-binding protein [Tribolium castaneum]>gi|270010405|gb|EFA06853.1| hypothetical protein TcasGA2_TC009796 [Tribolium castaneum] -- -- -- -- -- K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P48375 429 6.3e-41 12 kDa FK506-binding protein OS=Drosophila melanogaster GN=FK506-bp2 PE=3 SV=2 PF01581 FMRFamide related peptide family GO:0007218//GO:0006457//GO:0000413 neuropeptide signaling pathway//protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.35382 BF_2 10269.98 1074.44 687 91091510 XP_969238.1 886 8.2e-93 PREDICTED: 60S ribosomal protein L15 [Tribolium castaneum]>gi|642936867|ref|XP_008193026.1| PREDICTED: 60S ribosomal protein L15 [Tribolium castaneum]>gi|270000932|gb|EEZ97379.1| hypothetical protein TcasGA2_TC011204 [Tribolium castaneum] 315115480 HQ424769.1 142 3.45856e-66 Euphydryas aurinia ribosomal protein L15 (RpL15) mRNA, complete cds K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 P30736 776 1.9e-81 60S ribosomal protein L15 OS=Chironomus tentans GN=RpL15 PE=3 SV=3 PF00827 Ribosomal L15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.35383 BF_2 128.35 5.47 1269 91079320 XP_967967.1 669 2.2e-67 PREDICTED: probable DNA-3-methyladenine glycosylase [Tribolium castaneum]>gi|270004337|gb|EFA00785.1| hypothetical protein TcasGA2_TC003671 [Tribolium castaneum] -- -- -- -- -- K03652 MPG DNA-3-methyladenine glycosylase http://www.genome.jp/dbget-bin/www_bget?ko:K03652 Q04841 483 3.3e-47 DNA-3-methyladenine glycosylase OS=Mus musculus GN=Mpg PE=2 SV=3 PF02245 Methylpurine-DNA glycosylase (MPG) GO:0006284 base-excision repair GO:0003677//GO:0003905//GO:0003824 DNA binding//alkylbase DNA N-glycosylase activity//catalytic activity -- -- -- -- Cluster-8309.35384 BF_2 96.00 3.52 1428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35386 BF_2 34.83 1.05 1679 91095049 XP_972102.1 649 6.0e-65 PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911202|ref|XP_008199587.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911204|ref|XP_008199592.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911206|ref|XP_008199598.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|642911208|ref|XP_008199602.1| PREDICTED: protein rolling stone [Tribolium castaneum]>gi|270014768|gb|EFA11216.1| hypothetical protein TcasGA2_TC005180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44252 339 2.2e-30 Protein rolling stone OS=Drosophila melanogaster GN=rost PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35388 BF_2 7085.99 316.07 1225 546674527 ERL85887.1 1201 4.3e-129 hypothetical protein D910_03302 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15122 867 9.6e-92 Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.35389 BF_2 19.93 0.51 1931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02121 Phosphatidylinositol transfer protein GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.35390 BF_2 365.07 1.17 13340 642926407 XP_008191950.1 4357 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.22903e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.8e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF02121//PF00529//PF05920//PF03325//PF03699//PF10541//PF00046//PF02376 Phosphatidylinositol transfer protein//HlyD membrane-fusion protein of T1SS//Homeobox KN domain//Herpesvirus polymerase accessory protein//Uncharacterised protein family (UPF0182)//Nuclear envelope localisation domain//Homeobox domain//CUT domain GO:0006260//GO:0006355//GO:0006810//GO:0055085//GO:0019079 DNA replication//regulation of transcription, DNA-templated//transport//transmembrane transport//viral genome replication GO:0003677//GO:0030337 DNA binding//DNA polymerase processivity factor activity GO:0016020//GO:0005622//GO:0042575//GO:0016021 membrane//intracellular//DNA polymerase complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.35391 BF_2 16.53 0.77 1189 270005688 EFA02136.1 318 1.0e-26 hypothetical protein TcasGA2_TC007786 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35393 BF_2 7722.09 381.01 1135 674303998 AIL23530.1 1176 3.2e-126 ribosomal protein S3 [Tenebrio molitor] 642920571 XM_008194244.1 336 8.35149e-174 PREDICTED: Tribolium castaneum ribosomal protein S3 (RpS3), transcript variant X1, mRNA K02985 RP-S3e, RPS3 small subunit ribosomal protein S3e http://www.genome.jp/dbget-bin/www_bget?ko:K02985 P02350 1019 2.1e-109 40S ribosomal protein S3-A OS=Xenopus laevis GN=rps3-a PE=2 SV=2 PF07650 KH domain -- -- GO:0003723 RNA binding -- -- KOG3181 40S ribosomal protein S3 Cluster-8309.35394 BF_2 2691.57 801.53 427 91080173 XP_970371.1 349 9.4e-31 PREDICTED: cytochrome b-c1 complex subunit 8 [Tribolium castaneum]>gi|270006414|gb|EFA02862.1| ubiquinol-cytochrome c reductase, complex III subunit VII [Tribolium castaneum] -- -- -- -- -- K00418 QCR8, UQCRQ ubiquinol-cytochrome c reductase subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K00418 Q9CQ69 203 3.3e-15 Cytochrome b-c1 complex subunit 8 OS=Mus musculus GN=Uqcrq PE=1 SV=3 PF10890//PF02939 Protein of unknown function (DUF2741)//UcrQ family GO:0006119//GO:0015992//GO:0006118//GO:0022900 oxidative phosphorylation//proton transport//obsolete electron transport//electron transport chain GO:0008121 ubiquinol-cytochrome-c reductase activity GO:0005743//GO:0070469 mitochondrial inner membrane//respiratory chain KOG4116 Ubiquinol cytochrome c reductase, subunit QCR8 Cluster-8309.35395 BF_2 172.73 1.89 4101 546671316 ERL83681.1 930 3.9e-97 hypothetical protein D910_00859 [Dendroctonus ponderosae]>gi|546672389|gb|ERL84277.1| hypothetical protein D910_01664 [Dendroctonus ponderosae] -- -- -- -- -- K08002 MMP24 matrix metalloproteinase-24 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K08002 Q9GLE4 481 1.8e-46 Matrix metalloproteinase-14 OS=Bos taurus GN=MMP14 PE=2 SV=1 PF02691 Vacuolating cyotoxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.35396 BF_2 320.75 5.89 2567 270006955 EFA03403.1 2952 0.0e+00 hypothetical protein TcasGA2_TC013390 [Tribolium castaneum] 347966055 XM_321614.4 107 3.83444e-46 Anopheles gambiae str. PEST AGAP001507-PA (AgaP_AGAP001507) mRNA, complete cds K13647 PLODN procollagen-lysine,2-oxoglutarate 5-dioxygenase, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K13647 Q5U367 1892 2.8e-210 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 OS=Rattus norvegicus GN=Plod3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1971 Lysyl hydroxylase Cluster-8309.35398 BF_2 403.18 9.32 2096 189236205 XP_970721.2 673 1.2e-67 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.35399 BF_2 9039.93 123.19 3357 478262788 ENN81305.1 4017 0.0e+00 hypothetical protein YQE_02273, partial [Dendroctonus ponderosae]>gi|546672906|gb|ERL84622.1| hypothetical protein D910_02050 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2V2M9 1472 1.8e-161 FH1/FH2 domain-containing protein 3 OS=Homo sapiens GN=FHOD3 PE=1 SV=2 PF01059//PF06371 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Diaphanous GTPase-binding Domain GO:0030036//GO:0055114//GO:0006120 actin cytoskeleton organization//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG1925 Rac1 GTPase effector FHOS Cluster-8309.354 BF_2 6.39 0.42 920 642914430 XP_008201676.1 580 3.3e-57 PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum]>gi|642914432|ref|XP_008201677.1| PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XZC8 446 4.7e-43 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35400 BF_2 61.11 0.81 3452 478250766 ENN71258.1 1153 4.5e-123 hypothetical protein YQE_12185, partial [Dendroctonus ponderosae] -- -- -- -- -- K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 F1NHE9 770 4.8e-80 ATP-sensitive inward rectifier potassium channel 12 OS=Gallus gallus GN=KCNJ12 PE=1 SV=1 PF01007//PF15761 Inward rectifier potassium channel//Immortalisation up-regulated protein GO:0006813 potassium ion transport GO:0005242 inward rectifier potassium channel activity GO:0005634//GO:0016021//GO:0008076 nucleus//integral component of membrane//voltage-gated potassium channel complex KOG3827 Inward rectifier K+ channel Cluster-8309.35401 BF_2 19664.78 930.74 1171 642913599 XP_008201080.1 450 5.0e-42 PREDICTED: extensin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05109//PF03153 Herpes virus major outer envelope glycoprotein (BLLF1)//Transcription factor IIA, alpha/beta subunit GO:0006367//GO:0019058 transcription initiation from RNA polymerase II promoter//viral life cycle -- -- GO:0005672//GO:0019031 transcription factor TFIIA complex//viral envelope -- -- Cluster-8309.35402 BF_2 55.29 0.42 5812 699049757 AIU39233.1 742 3.4e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 532 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 1.2e-70 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF00769//PF11365//PF15898//PF03577//PF06160//PF10473//PF05739//PF10186//PF08702//PF04513//PF02601//PF07926//PF16326//PF07851//PF06009//PF14073 Ezrin/radixin/moesin family//Protein of unknown function (DUF3166)//cGMP-dependent protein kinase interacting domain//Peptidase family C69//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Vacuolar sorting 38 and autophagy-related subunit 14//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein//ABC transporter C-terminal domain//TMPIT-like protein//Laminin Domain II//Centrosome localisation domain of Cep57 GO:0006308//GO:0007155//GO:0010508//GO:0051258//GO:0007165//GO:0030168//GO:0006508//GO:0000921//GO:0006606//GO:0010506 DNA catabolic process//cell adhesion//positive regulation of autophagy//protein polymerization//signal transduction//platelet activation//proteolysis//septin ring assembly//protein import into nucleus//regulation of autophagy GO:0042803//GO:0043015//GO:0008855//GO:0005515//GO:0042802//GO:0003677//GO:0016805//GO:0019901//GO:0005198//GO:0030674//GO:0008092//GO:0005102//GO:0045502//GO:0008134 protein homodimerization activity//gamma-tubulin binding//exodeoxyribonuclease VII activity//protein binding//identical protein binding//DNA binding//dipeptidase activity//protein kinase binding//structural molecule activity//protein binding, bridging//cytoskeletal protein binding//receptor binding//dynein binding//transcription factor binding GO:0019031//GO:0005737//GO:0005940//GO:0016021//GO:0005667//GO:0030286//GO:0005615//GO:0005577//GO:0009318//GO:0045298//GO:0019898//GO:0019028 viral envelope//cytoplasm//septin ring//integral component of membrane//transcription factor complex//dynein complex//extracellular space//fibrinogen complex//exodeoxyribonuclease VII complex//tubulin complex//extrinsic component of membrane//viral capsid KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35403 BF_2 1527.01 18.48 3744 642921818 XP_008199331.1 2491 3.5e-278 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] 665798678 XM_008549002.1 56 1.25888e-17 PREDICTED: Microplitis demolitor vitamin K-dependent gamma-carboxylase (LOC103571031), transcript variant X3, mRNA K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 1371 1.1e-149 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.35404 BF_2 9412.42 396.98 1279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35406 BF_2 219.13 1.77 5474 270001371 EEZ97818.1 1191 2.8e-127 hypothetical protein TcasGA2_TC000185 [Tribolium castaneum] 642914990 XM_008192251.1 500 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X3, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 Q7TMK9 769 9.9e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 PF11411//PF16367//PF00076//PF07648//PF00023 DNA ligase IV//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Kazal-type serine protease inhibitor domain//Ankyrin repeat GO:0006281//GO:0006260 DNA repair//DNA replication GO:0005515//GO:0003910//GO:0003676 protein binding//DNA ligase (ATP) activity//nucleic acid binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.35407 BF_2 190.00 23.45 626 820805544 AKG92763.1 240 6.0e-18 max [Leptinotarsa decemlineata] 642929578 XM_970277.2 94 1.51132e-39 PREDICTED: Tribolium castaneum protein max (LOC664267), transcript variant X3, mRNA K04453 MAX Max protein http://www.genome.jp/dbget-bin/www_bget?ko:K04453 P28574 159 6.1e-10 Protein max OS=Mus musculus GN=Max PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG2483 Upstream transcription factor 2/L-myc-2 protein Cluster-8309.35408 BF_2 2276.77 25.10 4081 642930308 XP_008196340.1 966 2.6e-101 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 1.2e-34 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF03325//PF00439 Herpesvirus polymerase accessory protein//Bromodomain GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337//GO:0005515 DNA polymerase processivity factor activity//protein binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.35409 BF_2 1010.00 154.82 560 546677638 ERL88439.1 198 4.0e-13 hypothetical protein D910_05825 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02024//PF05791 Leptin//Bacillus haemolytic enterotoxin (HBL) GO:0007165//GO:0009405 signal transduction//pathogenesis GO:0005179 hormone activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.35413 BF_2 3395.39 76.87 2135 189240443 XP_972854.2 1224 1.6e-131 PREDICTED: lysosomal-associated transmembrane protein 4B [Tribolium castaneum] -- -- -- -- -- K12387 LAPTM lysosomal-associated transmembrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K12387 Q71SV0 285 5.1e-24 Lysosomal-associated transmembrane protein 4B OS=Bos taurus GN=LAPTM4B PE=2 SV=1 PF14991//PF03821 Protein melan-A//Golgi 4-transmembrane spanning transporter -- -- -- -- GO:0016021//GO:0042470 integral component of membrane//melanosome -- -- Cluster-8309.35415 BF_2 787.66 30.94 1352 270002990 EEZ99437.1 667 4.0e-67 hypothetical protein TcasGA2_TC030635 [Tribolium castaneum] -- -- -- -- -- K18646 ANP32A_C_D acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D http://www.genome.jp/dbget-bin/www_bget?ko:K18646 Q28XE2 547 1.3e-54 Acidic leucine-rich nuclear phosphoprotein 32 family member A OS=Drosophila pseudoobscura pseudoobscura GN=Anp32a PE=3 SV=2 PF13855//PF13516 Leucine rich repeat//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- KOG2739 Leucine-rich acidic nuclear protein Cluster-8309.35416 BF_2 8277.25 1096.17 603 264667375 ACY71273.1 745 1.6e-76 ribosomal protein S16 [Chrysomela tremula] 195123788 XM_002006349.1 138 5.04292e-64 Drosophila mojavensis GI21016 (Dmoj\GI21016), mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 P62251 661 3.6e-68 40S ribosomal protein S16 OS=Aedes aegypti GN=RpS16 PE=2 SV=1 PF00380 Ribosomal protein S9/S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.35417 BF_2 30685.54 1084.31 1471 674656865 AIL26079.1 768 8.4e-79 ferritin 2 [Monochamus alternatus] 674656864 KJ872588.1 138 1.2723e-63 Monochamus alternatus ferritin 2 mRNA, complete cds -- -- -- -- P41822 127 7.4e-06 Ferritin subunit OS=Aedes aegypti GN=FERH PE=1 SV=2 PF00210 Ferritin-like domain GO:0006879 cellular iron ion homeostasis GO:0008199 ferric iron binding -- -- -- -- Cluster-8309.35419 BF_2 3659.65 141.38 1370 91079744 XP_970506.1 1421 1.5e-154 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 768418014 XM_011551373.1 210 1.11773e-103 PREDICTED: Plutella xylostella probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial (LOC105381602), transcript variant X4, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1246 1.2e-135 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF00441//PF02770//PF02771 Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0008152//GO:0006118 oxidation-reduction process//metabolic process//obsolete electron transport GO:0016627//GO:0003995//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.35420 BF_2 10503.00 114.15 4136 194766015 XP_001965120.1 311 2.3e-25 GF23497 [Drosophila ananassae]>gi|190617730|gb|EDV33254.1| GF23497 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35421 BF_2 6839.61 30.09 9796 478255507 ENN75724.1 1979 2.1e-218 hypothetical protein YQE_07684, partial [Dendroctonus ponderosae] -- -- -- -- -- K17800 LETM1, MDM38 LETM1 and EF-hand domain-containing protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17800 P91927 1023 6.2e-109 LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial OS=Drosophila melanogaster GN=Letm1 PE=2 SV=2 PF13499 EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7 Cluster-8309.35423 BF_2 177.00 14.52 797 332375993 AEE63137.1 801 6.8e-83 unknown [Dendroctonus ponderosae]>gi|478258109|gb|ENN78247.1| hypothetical protein YQE_05398, partial [Dendroctonus ponderosae]>gi|546682789|gb|ERL92678.1| hypothetical protein D910_09990 [Dendroctonus ponderosae] -- -- -- -- -- K02871 RP-L13, MRPL13, rplM large subunit ribosomal protein L13 http://www.genome.jp/dbget-bin/www_bget?ko:K02871 Q9VJ38 693 9.3e-72 39S ribosomal protein L13, mitochondrial OS=Drosophila melanogaster GN=mRpL13 PE=2 SV=2 PF00572 Ribosomal protein L13 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3203 Mitochondrial/chloroplast ribosomal protein L13 Cluster-8309.35426 BF_2 16359.25 95.62 7444 642920903 XP_008192608.1 9659 0.0e+00 PREDICTED: spectrin beta chain isoform X2 [Tribolium castaneum] 642920904 XM_008194387.1 1976 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X5, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7569 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00435//PF00307 Spectrin repeat//Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.35428 BF_2 7467.18 842.29 658 805784468 XP_003703131.2 919 1.2e-96 PREDICTED: 60S ribosomal protein L9 [Megachile rotundata] 264667320 GU120396.1 237 5.11632e-119 Chrysomela tremulae ribosomal protein L9 (RpL9) mRNA, complete cds K02940 RP-L9e, RPL9 large subunit ribosomal protein L9e http://www.genome.jp/dbget-bin/www_bget?ko:K02940 Q963B7 849 6.3e-90 60S ribosomal protein L9 OS=Spodoptera frugiperda GN=RpL9 PE=2 SV=1 PF00347 Ribosomal protein L6 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0019843 structural constituent of ribosome//rRNA binding GO:0005840 ribosome KOG3255 60S ribosomal protein L9 Cluster-8309.35430 BF_2 1341.14 9.48 6205 642935181 XP_008199681.1 2449 4.2e-273 PREDICTED: uncharacterized protein LOC655640 [Tribolium castaneum]>gi|642935183|ref|XP_008199682.1| PREDICTED: uncharacterized protein LOC655640 [Tribolium castaneum]>gi|642935185|ref|XP_008199683.1| PREDICTED: uncharacterized protein LOC655640 [Tribolium castaneum] 642935184 XM_008201461.1 395 0 PREDICTED: Tribolium castaneum uncharacterized LOC655640 (LOC655640), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35433 BF_2 816.05 41.54 1109 642919985 XP_975111.2 901 2.4e-94 PREDICTED: 7-methylguanosine phosphate-specific 5'-nucleotidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9W197 645 4.8e-66 7-methylguanosine phosphate-specific 5'-nucleotidase OS=Drosophila melanogaster GN=CG3362 PE=1 SV=1 PF05822 Pyrimidine 5'-nucleotidase (UMPH-1) -- -- GO:0008253//GO:0000287 5'-nucleotidase activity//magnesium ion binding GO:0005737 cytoplasm KOG3128 Uncharacterized conserved protein Cluster-8309.35435 BF_2 3016.00 61.82 2328 270014974 EFA11422.1 534 1.8e-51 hypothetical protein TcasGA2_TC013599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35436 BF_2 2151.76 79.04 1426 91080861 XP_971851.1 1327 1.2e-143 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [Tribolium castaneum]>gi|270006430|gb|EFA02878.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 [Tribolium castaneum] -- -- -- -- -- K03954 NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03954 P91929 984 3.0e-105 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Drosophila melanogaster GN=ND42 PE=2 SV=2 PF03796//PF02367//PF02224 DnaB-like helicase C terminal domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Cytidylate kinase GO:0006139//GO:0002949//GO:0006260//GO:0006206 nucleobase-containing compound metabolic process//tRNA threonylcarbamoyladenosine modification//DNA replication//pyrimidine nucleobase metabolic process GO:0005524//GO:0003678//GO:0004127 ATP binding//DNA helicase activity//cytidylate kinase activity GO:0005657 replication fork KOG3877 NADH:ubiquinone oxidoreductase, NDUFA10/42kDa subunit Cluster-8309.35438 BF_2 91.94 2.50 1827 642915291 XP_008190557.1 1283 2.0e-138 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 602 7.6e-61 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.35439 BF_2 374.10 4.72 3604 817053577 XP_012262754.1 1796 1.3e-197 PREDICTED: nucleolar protein 58 [Athalia rosae] 242020751 XM_002430770.1 269 4.7558e-136 Pediculus humanus corporis Nucleolar protein NOP5, putative, mRNA K14565 NOP58 nucleolar protein 58 http://www.genome.jp/dbget-bin/www_bget?ko:K14565 Q9Y2X3 1418 3.6e-155 Nucleolar protein 58 OS=Homo sapiens GN=NOP58 PE=1 SV=1 PF04858//PF08769//PF11802 TH1 protein//Sporulation initiation factor Spo0A C terminal//Centromere-associated protein K GO:0006355//GO:0045892//GO:0042173 regulation of transcription, DNA-templated//negative regulation of transcription, DNA-templated//regulation of sporulation resulting in formation of a cellular spore GO:0005509//GO:0003700 calcium ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005737 nucleus//transcription factor complex//cytoplasm KOG2572 Ribosome biogenesis protein - Nop58p/Nop5p Cluster-8309.35440 BF_2 129.00 6.64 1100 91078898 XP_973390.1 1001 6.0e-106 PREDICTED: negative elongation factor D [Tribolium castaneum]>gi|270004155|gb|EFA00603.1| hypothetical protein TcasGA2_TC003474 [Tribolium castaneum] -- -- -- -- -- K15181 TH1L, NELFD negative elongation factor C/D http://www.genome.jp/dbget-bin/www_bget?ko:K15181 Q24134 801 3.9e-84 Negative elongation factor D OS=Drosophila melanogaster GN=TH1 PE=1 SV=2 PF04858 TH1 protein GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.35441 BF_2 1.00 0.34 410 478266103 ENN82685.1 268 2.2e-21 hypothetical protein YQE_00944, partial [Dendroctonus ponderosae] -- -- -- -- -- K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 256 2.3e-21 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0671 LAMMER dual specificity kinases Cluster-8309.35443 BF_2 120.34 2.31 2463 91091790 XP_970226.1 2316 4.5e-258 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X1 [Tribolium castaneum] 195481875 XM_002101781.1 65 8.18764e-23 Drosophila yakuba GE15405 (Dyak\GE15405), partial mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1574 2.0e-173 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.35444 BF_2 49.81 0.44 5063 642933627 XP_008197501.1 1471 8.8e-160 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Tribolium castaneum] 676386870 XM_009038466.1 51 1.02716e-14 Aureococcus anophagefferens hypothetical protein partial mRNA K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60484 854 1.3e-89 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens GN=PTEN PE=1 SV=1 PF05706//PF00102//PF00782 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0004721//GO:0008138 protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases Cluster-8309.35447 BF_2 17.63 0.34 2488 646709417 KDR15281.1 708 1.3e-71 Peptidyl-prolyl cis-trans isomerase [Zootermopsis nevadensis] 755876427 XM_005183940.2 153 9.96959e-72 PREDICTED: Musca domestica peptidyl-prolyl cis-trans isomerase (LOC101898665), mRNA K09565 PPIF peptidyl-prolyl isomerase F (cyclophilin D) http://www.genome.jp/dbget-bin/www_bget?ko:K09565 P54985 683 4.2e-70 Peptidyl-prolyl cis-trans isomerase OS=Blattella germanica GN=CYPA PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.35448 BF_2 2000.00 143.06 872 91087761 XP_974991.1 1012 2.5e-107 PREDICTED: proteasome subunit beta type-4 [Tribolium castaneum]>gi|270009385|gb|EFA05833.1| hypothetical protein TcasGA2_TC008617 [Tribolium castaneum] -- -- -- -- -- K02736 PSMB4 20S proteasome subunit beta 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02736 P99026 683 1.5e-70 Proteasome subunit beta type-4 OS=Mus musculus GN=Psmb4 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839 cytoplasm//nucleus//proteasome core complex KOG0185 20S proteasome, regulatory subunit beta type PSMB4/PRE4 Cluster-8309.35450 BF_2 113.00 87.79 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35451 BF_2 61.00 3.45 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35455 BF_2 38.63 1.59 1303 546674022 ERL85515.1 440 8.0e-41 hypothetical protein D910_02934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15330 182 2.7e-12 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35459 BF_2 26.69 0.48 2637 817086172 XP_012265802.1 1842 4.4e-203 PREDICTED: stress-induced-phosphoprotein 1 isoform X2 [Athalia rosae] 831315386 XM_012834849.1 54 1.1431e-16 PREDICTED: Clupea harengus stress-induced phosphoprotein 1 (stip1), mRNA K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q4R8N7 1433 4.8e-157 Stress-induced-phosphoprotein 1 OS=Macaca fascicularis GN=STIP1 PE=2 SV=1 PF13181//PF02064//PF13174//PF00515//PF13374//PF13371//PF09392//PF13414//PF13176 Tetratricopeptide repeat//MAS20 protein import receptor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//TPR repeat//Tetratricopeptide repeat GO:0006605//GO:0009405//GO:0015031//GO:0006886 protein targeting//pathogenesis//protein transport//intracellular protein transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG0548 Molecular co-chaperone STI1 Cluster-8309.35460 BF_2 912.00 26.01 1754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01912 eIF-6 family GO:0042256 mature ribosome assembly GO:0043022 ribosome binding -- -- -- -- Cluster-8309.35462 BF_2 246.21 7.31 1696 478257813 ENN77956.1 1791 2.3e-197 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 9.3e-29 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35463 BF_2 486.81 9.81 2364 642930224 XP_008196307.1 2219 7.6e-247 PREDICTED: probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial [Tribolium castaneum] 543271752 XM_005425019.1 98 3.55206e-41 PREDICTED: Geospiza fortis methylcrotonoyl-CoA carboxylase beta chain, mitochondrial-like (LOC102043970), mRNA K01969 E6.4.1.4B 3-methylcrotonyl-CoA carboxylase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01969 Q9V9A7 1913 9.4e-213 Probable methylcrotonoyl-CoA carboxylase beta chain, mitochondrial OS=Drosophila melanogaster GN=l(2)04524 PE=2 SV=1 PF10186//PF00484//PF06833 Vacuolar sorting 38 and autophagy-related subunit 14//Carbonic anhydrase//Malonate decarboxylase gamma subunit (MdcE) GO:0006730//GO:0006807//GO:0010508 one-carbon metabolic process//nitrogen compound metabolic process//positive regulation of autophagy GO:0008270//GO:0004089//GO:0016874 zinc ion binding//carbonate dehydratase activity//ligase activity -- -- KOG0540 3-Methylcrotonyl-CoA carboxylase, non-biotin containing subunit/Acetyl-CoA carboxylase carboxyl transferase, subunit beta Cluster-8309.35465 BF_2 1836.02 48.37 1875 642931046 XP_008196190.1 741 1.5e-75 PREDICTED: myeloid leukemia factor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NKV0 353 5.8e-32 Myeloid leukemia factor OS=Drosophila melanogaster GN=Mlf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35466 BF_2 70.64 1.90 1843 91090488 XP_968919.1 1888 1.4e-208 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X2 [Tribolium castaneum]>gi|270013864|gb|EFA10312.1| hypothetical protein TcasGA2_TC012528 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q02157 585 7.2e-59 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.35467 BF_2 14.94 0.64 1269 642935348 XP_008197977.1 720 2.7e-73 PREDICTED: inactive pancreatic lipase-related protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14073 PNLIP, PL pancreatic triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14073 Q02157 259 3.1e-21 Pancreatic triacylglycerol lipase OS=Oryctolagus cuniculus GN=PNLIP PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35469 BF_2 1845.71 63.04 1512 91085705 XP_972760.1 563 5.1e-55 PREDICTED: UBX domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5HZY0 325 8.3e-29 UBX domain-containing protein 4 OS=Rattus norvegicus GN=Ubxn4 PE=2 SV=1 PF05279//PF00789//PF05602 Aspartyl beta-hydroxylase N-terminal region//UBX domain//Cleft lip and palate transmembrane protein 1 (CLPTM1) -- -- GO:0005515 protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG2507 Ubiquitin regulatory protein UBXD2, contains UAS and UBX domains Cluster-8309.35470 BF_2 2176.29 59.90 1807 91090714 XP_975034.1 834 2.3e-86 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 378 7.1e-35 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 PF03688 Nepovirus coat protein, C-terminal domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.35471 BF_2 290.65 2.51 5134 91077054 XP_966585.1 1457 3.8e-158 PREDICTED: probable transaldolase [Tribolium castaneum]>gi|270001740|gb|EEZ98187.1| hypothetical protein TcasGA2_TC000616 [Tribolium castaneum] 746851965 XM_011058220.1 116 7.66355e-51 PREDICTED: Acromyrmex echinatior probable transaldolase (LOC105147307), mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 Q9EQS0 1175 7.7e-127 Transaldolase OS=Rattus norvegicus GN=Taldo1 PE=1 SV=2 PF02428//PF00923//PF15966//PF00646//PF12937//PF13855 Potato type II proteinase inhibitor family//Transaldolase//F-box//F-box domain//F-box-like//Leucine rich repeat GO:0006098//GO:0005975 pentose-phosphate shunt//carbohydrate metabolic process GO:0005515//GO:0004801//GO:0004867 protein binding//sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity//serine-type endopeptidase inhibitor activity GO:0005737 cytoplasm KOG2772 Transaldolase Cluster-8309.35472 BF_2 1370.86 16.57 3749 642910505 XP_008200243.1 2511 1.7e-280 PREDICTED: SEC23-interacting protein isoform X2 [Tribolium castaneum] 826487484 XM_012683938.1 80 5.74175e-31 PREDICTED: Monomorium pharaonis SEC23-interacting protein-like (LOC105838396), transcript variant X4, mRNA -- -- -- -- Q9Y6Y8 919 2.7e-97 SEC23-interacting protein OS=Homo sapiens GN=SEC23IP PE=1 SV=1 PF02862//PF13724//PF10425 DDHD domain//DNA-binding domain//C-terminus of bacterial fibrinogen-binding adhesin GO:0007155 cell adhesion GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005618 cell wall KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.35474 BF_2 1549.00 16.71 4165 189239123 XP_970925.2 1754 1.1e-192 PREDICTED: protein bicaudal D [Tribolium castaneum]>gi|270011010|gb|EFA07458.1| bicaudal D [Tribolium castaneum] 268536819 XM_002633499.1 38 1.42179e-07 Caenorhabditis briggsae Hypothetical protein CBG05413 (CBG05413) mRNA, complete cds K18739 BICD protein bicaudal D http://www.genome.jp/dbget-bin/www_bget?ko:K18739 P16568 1092 2.6e-117 Protein bicaudal D OS=Drosophila melanogaster GN=BicD PE=1 SV=2 PF08702//PF02183//PF10473//PF10018//PF01544//PF10186//PF09730//PF09510//PF04111//PF06156//PF04632 Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Vitamin-D-receptor interacting Mediator subunit 4//CorA-like Mg2+ transporter protein//Vacuolar sorting 38 and autophagy-related subunit 14//Microtubule-associated protein Bicaudal-D//Rtt102p-like transcription regulator protein//Autophagy protein Apg6//Protein of unknown function (DUF972)//Fusaric acid resistance protein family GO:0010508//GO:0006355//GO:0006357//GO:0006260//GO:0006914//GO:0051258//GO:0006338//GO:0006810//GO:0007165//GO:0055085//GO:0030168//GO:0030001 positive regulation of autophagy//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//DNA replication//autophagy//protein polymerization//chromatin remodeling//transport//signal transduction//transmembrane transport//platelet activation//metal ion transport GO:0003700//GO:0043565//GO:0005102//GO:0045502//GO:0008134//GO:0042803//GO:0030674//GO:0046873//GO:0001104 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//receptor binding//dynein binding//transcription factor binding//protein homodimerization activity//protein binding, bridging//metal ion transmembrane transporter activity//RNA polymerase II transcription cofactor activity GO:0005577//GO:0005794//GO:0016586//GO:0016514//GO:0016020//GO:0005667//GO:0016592//GO:0005634//GO:0005886//GO:0030286 fibrinogen complex//Golgi apparatus//RSC complex//SWI/SNF complex//membrane//transcription factor complex//mediator complex//nucleus//plasma membrane//dynein complex KOG0999 Microtubule-associated protein Bicaudal-D Cluster-8309.35475 BF_2 22156.06 1002.17 1212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35479 BF_2 426.47 13.52 1607 332372740 AEE61512.1 592 2.4e-58 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PWV1 213 8.6e-16 Aquaporin AQPAn.G OS=Anopheles gambiae GN=AGAP008842 PE=3 SV=4 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.35480 BF_2 6.65 1.33 497 332375004 AEE62643.1 220 9.9e-16 unknown [Dendroctonus ponderosae]>gi|478258425|gb|ENN78519.1| hypothetical protein YQE_05012, partial [Dendroctonus ponderosae]>gi|546676434|gb|ERL87445.1| hypothetical protein D910_04837 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02936 Cytochrome c oxidase subunit IV GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.35482 BF_2 12.22 0.47 1386 478257902 ENN78042.1 363 7.3e-32 hypothetical protein YQE_05479, partial [Dendroctonus ponderosae] -- -- -- -- -- K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35483 BF_2 66.53 0.50 5854 699049757 AIU39233.1 742 3.5e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 606 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 1.2e-70 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF10186//PF00769//PF11365//PF15898//PF03577//PF06160//PF10473//PF05739//PF16326//PF07851//PF06009//PF14073//PF04513//PF08702//PF02601//PF07926 Vacuolar sorting 38 and autophagy-related subunit 14//Ezrin/radixin/moesin family//Protein of unknown function (DUF3166)//cGMP-dependent protein kinase interacting domain//Peptidase family C69//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//ABC transporter C-terminal domain//TMPIT-like protein//Laminin Domain II//Centrosome localisation domain of Cep57//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein GO:0010508//GO:0007165//GO:0051258//GO:0007155//GO:0006308//GO:0006606//GO:0010506//GO:0030168//GO:0006508//GO:0000921 positive regulation of autophagy//signal transduction//protein polymerization//cell adhesion//DNA catabolic process//protein import into nucleus//regulation of autophagy//platelet activation//proteolysis//septin ring assembly GO:0019901//GO:0016805//GO:0005198//GO:0043015//GO:0042803//GO:0003677//GO:0042802//GO:0005515//GO:0008855//GO:0005102//GO:0045502//GO:0008134//GO:0030674//GO:0008092 protein kinase binding//dipeptidase activity//structural molecule activity//gamma-tubulin binding//protein homodimerization activity//DNA binding//identical protein binding//protein binding//exodeoxyribonuclease VII activity//receptor binding//dynein binding//transcription factor binding//protein binding, bridging//cytoskeletal protein binding GO:0005737//GO:0016021//GO:0005940//GO:0019031//GO:0009318//GO:0005577//GO:0005615//GO:0019898//GO:0019028//GO:0045298//GO:0030286//GO:0005667 cytoplasm//integral component of membrane//septin ring//viral envelope//exodeoxyribonuclease VII complex//fibrinogen complex//extracellular space//extrinsic component of membrane//viral capsid//tubulin complex//dynein complex//transcription factor complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35484 BF_2 738.07 15.72 2251 478256393 ENN76583.1 2095 1.7e-232 hypothetical protein YQE_07032, partial [Dendroctonus ponderosae]>gi|546680826|gb|ERL91032.1| hypothetical protein D910_08374 [Dendroctonus ponderosae] 167515085 EU267006.1 35 3.5513e-06 Aedes aegypti sodium-dependent nutrient amino acid transporter 8 (NAT8) mRNA, complete cds K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 Q29GB8 1429 1.2e-156 Sodium-dependent nutrient amino acid transporter 1 OS=Drosophila pseudoobscura pseudoobscura GN=NAAT1 PE=3 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.35486 BF_2 31.18 0.38 3707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35487 BF_2 1567.18 24.03 3015 189239379 XP_971918.2 690 1.9e-69 PREDICTED: receptor expression-enhancing protein 5 [Tribolium castaneum]>gi|270009667|gb|EFA06115.1| hypothetical protein TcasGA2_TC008958 [Tribolium castaneum] 667676433 AE013599.5 78 5.95915e-30 Drosophila melanogaster chromosome 2R K17279 REEP5_6 receptor expression-enhancing protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K17279 Q29RM3 475 6.7e-46 Receptor expression-enhancing protein 5 OS=Bos taurus GN=REEP5 PE=2 SV=1 PF00886 Ribosomal protein S16 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1725 Protein involved in membrane traffic (YOP1/TB2/DP1/HVA22 family) Cluster-8309.35491 BF_2 542.06 14.22 1882 642919171 XP_967331.2 1405 1.5e-152 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q810J8 991 6.1e-106 Zinc finger FYVE domain-containing protein 1 OS=Mus musculus GN=Zfyve1 PE=2 SV=2 PF01926//PF02263//PF04548 50S ribosome-binding GTPase//Guanylate-binding protein, N-terminal domain//AIG1 family -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- -- -- Cluster-8309.35492 BF_2 558.00 14.29 1921 332376593 AEE63436.1 947 1.9e-99 unknown [Dendroctonus ponderosae]>gi|478257059|gb|ENN77222.1| hypothetical protein YQE_06052, partial [Dendroctonus ponderosae] -- -- -- -- -- K14713 SLC39A7, KE4, ZIP7 solute carrier family 39 (zinc transporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14713 Q9V3A4 738 1.4e-76 Protein catecholamines up OS=Drosophila melanogaster GN=Catsup PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.35493 BF_2 28038.20 359.14 3553 546683948 ERL93688.1 203 6.7e-13 hypothetical protein D910_10975 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35495 BF_2 250.18 5.15 2318 478255733 ENN75942.1 1799 3.7e-198 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 810 7.4e-85 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF08119//PF00097 Scorpion acidic alpha-KTx toxin family//Zinc finger, C3HC4 type (RING finger) GO:0009405//GO:0006810 pathogenesis//transport GO:0046872//GO:0019870 metal ion binding//potassium channel inhibitor activity GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.35498 BF_2 357.34 9.10 1929 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35499 BF_2 5.19 0.60 649 630314895 AET80385.2 466 3.9e-44 putative delta-1-pyrroline-5-carboxylate dehydrogenase [Leptinotarsa decemlineata] -- -- -- -- -- K00294 E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00294 P30038 235 9.7e-19 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens GN=ALDH4A1 PE=1 SV=3 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase Cluster-8309.35501 BF_2 2031.61 34.26 2768 642927261 XP_008195198.1 1294 1.6e-139 PREDICTED: GDP-fucose protein O-fucosyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K03691 POFUT peptide-O-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03691 Q9W589 731 1.3e-75 GDP-fucose protein O-fucosyltransferase 2 OS=Drosophila melanogaster GN=O-fut2 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005839 proteasome core complex KOG0175 20S proteasome, regulatory subunit beta type PSMB5/PSMB8/PRE2 Cluster-8309.35502 BF_2 66.16 0.73 4073 642923778 XP_008193880.1 997 6.5e-105 PREDICTED: zinc finger protein 395 isoform X1 [Tribolium castaneum] 462336375 APGK01037911.1 36 1.79822e-06 Dendroctonus ponderosae Seq01037921, whole genome shotgun sequence -- -- -- -- Q6DFC8 154 1.5e-08 Zinc finger protein 395 OS=Xenopus laevis GN=znf395 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35503 BF_2 31.13 0.62 2372 478263485 ENN81840.1 578 1.5e-56 hypothetical protein YQE_01779, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35504 BF_2 38.00 6.36 537 478259961 ENN79763.1 604 3.2e-60 hypothetical protein YQE_03819, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35505 BF_2 691.00 31.56 1203 749731807 XP_011136864.1 1293 9.1e-140 PREDICTED: eukaryotic translation initiation factor 2 subunit 1 [Harpegnathos saltator]>gi|749731809|ref|XP_011136872.1| PREDICTED: eukaryotic translation initiation factor 2 subunit 1 [Harpegnathos saltator] 820840867 XM_003691501.2 401 0 PREDICTED: Apis florea eukaryotic translation initiation factor 2 subunit 1 (LOC100870691), mRNA K03237 EIF2S1 translation initiation factor 2 subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03237 P41374 1060 3.9e-114 Eukaryotic translation initiation factor 2 subunit 1 OS=Drosophila melanogaster GN=eIF-2alpha PE=2 SV=1 PF00575//PF07541 S1 RNA binding domain//Eukaryotic translation initiation factor 2 alpha subunit GO:0006446 regulation of translational initiation GO:0003723//GO:0003743//GO:0003676 RNA binding//translation initiation factor activity//nucleic acid binding GO:0005850//GO:0005840 eukaryotic translation initiation factor 2 complex//ribosome KOG2916 Translation initiation factor 2, alpha subunit (eIF-2alpha) Cluster-8309.35506 BF_2 20.88 0.34 2862 642911817 XP_008200757.1 2573 8.2e-288 PREDICTED: histone-arginine methyltransferase CARMER isoform X1 [Tribolium castaneum]>gi|270014548|gb|EFA10996.1| hypothetical protein TcasGA2_TC004581 [Tribolium castaneum] -- -- -- -- -- K05931 CARM1, PRMT4 histone-arginine methyltransferase CARM1 http://www.genome.jp/dbget-bin/www_bget?ko:K05931 Q174R2 1725 7.2e-191 Histone-arginine methyltransferase CARMER OS=Aedes aegypti GN=CARM1 PE=3 SV=1 PF00443//PF05175//PF08241//PF05185//PF01465//PF03602//PF15127//PF03153 Ubiquitin carboxyl-terminal hydrolase//Methyltransferase small domain//Methyltransferase domain//PRMT5 arginine-N-methyltransferase//GRIP domain//Conserved hypothetical protein 95//Small membrane A-kinase anchor protein//Transcription factor IIA, alpha/beta subunit GO:0031167//GO:0008152//GO:0006367//GO:0016579//GO:0000042//GO:0006479 rRNA methylation//metabolic process//transcription initiation from RNA polymerase II promoter//protein deubiquitination//protein targeting to Golgi//protein methylation GO:0034237//GO:0005515//GO:0036459//GO:0008168 protein kinase A regulatory subunit binding//protein binding//ubiquitinyl hydrolase activity//methyltransferase activity GO:0005672 transcription factor TFIIA complex KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.35509 BF_2 2428.77 12.87 8184 270015918 EFA12366.1 1004 2.0e-105 hypothetical protein TcasGA2_TC002072 [Tribolium castaneum] 642938736 XM_008201646.1 149 5.53723e-69 PREDICTED: Tribolium castaneum RNA polymerase II elongation factor ELL (LOC655479), mRNA K15183 ELL RNA polymerase II elongation factor ELL http://www.genome.jp/dbget-bin/www_bget?ko:K15183 P55199 278 1.3e-22 RNA polymerase II elongation factor ELL OS=Homo sapiens GN=ELL PE=1 SV=1 PF10390//PF05732 RNA polymerase II elongation factor ELL//Firmicute plasmid replication protein (RepL) GO:0006368//GO:0006260//GO:0006276 transcription elongation from RNA polymerase II promoter//DNA replication//plasmid maintenance -- -- GO:0008023 transcription elongation factor complex -- -- Cluster-8309.35511 BF_2 820.17 23.28 1761 189241794 XP_976078.2 1228 4.6e-132 PREDICTED: 26S proteasome non-ATPase regulatory subunit 4 isoform X2 [Tribolium castaneum]>gi|270001159|gb|EEZ97606.1| hypothetical protein TcasGA2_TC011476 [Tribolium castaneum] 642937780 XM_970985.3 201 1.45535e-98 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 4 (LOC658092), transcript variant X2, mRNA K03029 PSMD4, RPN10 26S proteasome regulatory subunit N10 http://www.genome.jp/dbget-bin/www_bget?ko:K03029 Q58DA0 895 7.8e-95 26S proteasome non-ATPase regulatory subunit 4 OS=Bos taurus GN=PSMD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2884 26S proteasome regulatory complex, subunit RPN10/PSMD4 Cluster-8309.35512 BF_2 1670.56 203.23 631 821003176 XP_012365190.1 1042 6.1e-111 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 768431775 XM_011558880.1 281 1.69935e-143 PREDICTED: Plutella xylostella polyubiquitin-A (LOC105388041), transcript variant X5, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 1042 2.5e-112 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560//PF04452 Ubiquitin family//Ubiquitin-like domain//RNA methyltransferase GO:0006364 rRNA processing GO:0005515//GO:0008168 protein binding//methyltransferase activity -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35513 BF_2 4228.87 298.40 880 353231251 CCD77669.1 924 4.1e-97 putative ubiquitin (ribosomal protein L40) [Schistosoma mansoni] 260830118 XM_002609963.1 308 2.35755e-158 Branchiostoma floridae hypothetical protein, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 919 6.4e-98 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF04452//PF00240//PF14560 RNA methyltransferase//Ubiquitin family//Ubiquitin-like domain GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35514 BF_2 252.01 7.78 1643 642933218 XP_008197312.1 1256 2.4e-135 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 843 7.8e-89 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF04369//PF00083//PF00854 Major Facilitator Superfamily//Lactococcin-like family//Sugar (and other) transporter//POT family GO:0006810//GO:0042742//GO:0055085 transport//defense response to bacterium//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021//GO:0005576//GO:0016020 integral component of membrane//extracellular region//membrane -- -- Cluster-8309.35515 BF_2 574.43 15.52 1835 91081787 XP_973692.1 773 2.8e-79 PREDICTED: uncharacterized protein LOC662508 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05281 Neuroendocrine protein 7B2 precursor (Secretogranin V) GO:0007218 neuropeptide signaling pathway -- -- GO:0030141 secretory granule -- -- Cluster-8309.35517 BF_2 862.78 14.32 2808 478255416 ENN75638.1 1298 5.6e-140 hypothetical protein YQE_07816, partial [Dendroctonus ponderosae] -- -- -- -- -- K01597 MVD, mvaD diphosphomevalonate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01597 Q0P570 987 2.7e-105 Diphosphomevalonate decarboxylase OS=Bos taurus GN=MVD PE=2 SV=1 PF04627//PF00288 Mitochondrial ATP synthase epsilon chain//GHMP kinases N terminal domain GO:0015992//GO:0015986//GO:0006119 proton transport//ATP synthesis coupled proton transport//oxidative phosphorylation GO:0046933//GO:0046961//GO:0005524 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//ATP binding GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG2833 Mevalonate pyrophosphate decarboxylase Cluster-8309.35518 BF_2 2372.79 23.14 4576 642916846 XP_008199527.1 814 1.2e-83 PREDICTED: failed axon connections isoform X2 [Tribolium castaneum]>gi|270003072|gb|EEZ99519.1| hypothetical protein TcasGA2_TC000100 [Tribolium castaneum] 642916844 XM_963303.3 271 4.678e-137 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X1, mRNA -- -- -- -- Q95RI5 693 5.4e-71 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF13417//PF05132//PF02724//PF06213//PF16834//PF02535//PF06459 Glutathione S-transferase, N-terminal domain//RNA polymerase III RPC4//CDC45-like protein//Cobalamin biosynthesis protein CobT//Shu complex component Csm2, DNA-binding//ZIP Zinc transporter//Ryanodine Receptor TM 4-6 GO:0006874//GO:0009236//GO:0006816//GO:0055085//GO:0006270//GO:0006206//GO:0000725//GO:0006351//GO:0030001//GO:0006383//GO:0006144 cellular calcium ion homeostasis//cobalamin biosynthetic process//calcium ion transport//transmembrane transport//DNA replication initiation//pyrimidine nucleobase metabolic process//recombinational repair//transcription, DNA-templated//metal ion transport//transcription from RNA polymerase III promoter//purine nucleobase metabolic process GO:0003899//GO:0046873//GO:0003677//GO:0005219//GO:0005515 DNA-directed RNA polymerase activity//metal ion transmembrane transporter activity//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding GO:0005622//GO:0005666//GO:0005730//GO:0016021//GO:0097196//GO:0016020//GO:0005634 intracellular//DNA-directed RNA polymerase III complex//nucleolus//integral component of membrane//Shu complex//membrane//nucleus -- -- Cluster-8309.35519 BF_2 4221.89 74.81 2648 642928387 XP_008192723.1 1186 5.1e-127 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Tribolium castaneum] 852728203 XM_013016081.1 97 1.43333e-40 PREDICTED: Dipodomys ordii dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA K00658 DLST, sucB 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00658 Q90512 1089 3.7e-117 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (Fragment) OS=Takifugu rubripes GN=dlst PE=3 SV=1 PF07831//PF00198 Pyrimidine nucleoside phosphorylase C-terminal domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain) GO:0006213//GO:0008152 pyrimidine nucleoside metabolic process//metabolic process GO:0016746//GO:0016763 transferase activity, transferring acyl groups//transferase activity, transferring pentosyl groups -- -- KOG0559 Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) Cluster-8309.35520 BF_2 530.14 4.95 4767 642915350 XP_008190583.1 277 2.3e-21 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q86MW9 234 9.4e-18 E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni GN=SINA PE=1 SV=1 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.35521 BF_2 38.10 0.62 2839 478250432 ENN70927.1 576 3.0e-56 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] 645036882 XM_001607897.2 186 5.15071e-90 PREDICTED: Nasonia vitripennis histone H2A-like (LOC100114644), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84052 471 1.8e-45 Histone H2A OS=Drosophila erecta GN=His2A PE=3 SV=2 PF00656//PF00125//PF12513 Caspase domain//Core histone H2A/H2B/H3/H4//Mitochondrial degradasome RNA helicase subunit C terminal GO:0006508 proteolysis GO:0016817//GO:0004197//GO:0003677 hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//DNA binding -- -- -- -- Cluster-8309.35522 BF_2 1012.05 141.65 586 270011805 EFA08253.1 223 5.3e-16 hypothetical protein TcasGA2_TC005881 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.35523 BF_2 6740.90 125.11 2541 741829858 AJA91073.1 1786 1.3e-196 cytochrome P450 [Leptinotarsa decemlineata] 749794849 XM_011152479.1 40 6.6729e-09 PREDICTED: Harpegnathos saltator cytochrome P450 9e2-like (LOC105190010), mRNA K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1244 3.8e-135 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.35524 BF_2 1051.59 18.55 2659 642938021 XP_008199174.1 3463 0.0e+00 PREDICTED: alpha-aminoadipic semialdehyde synthase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270015713|gb|EFA12161.1| hypothetical protein TcasGA2_TC002311 [Tribolium castaneum] -- -- -- -- -- K14157 AASS alpha-aminoadipic semialdehyde synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14157 A2VCW9 2123 4.7e-237 Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Rattus norvegicus GN=Aass PE=2 SV=1 PF01118//PF01113//PF02254//PF03435//PF03447//PF01408//PF13241//PF02826 Semialdehyde dehydrogenase, NAD binding domain//Dihydrodipicolinate reductase, N-terminus//TrkA-N domain//Saccharopine dehydrogenase NADP binding domain//Homoserine dehydrogenase, NAD binding domain//Oxidoreductase family, NAD-binding Rossmann fold//Putative NAD(P)-binding//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0009089//GO:0019354//GO:0009085//GO:0006813//GO:0006779//GO:0055114 lysine biosynthetic process via diaminopimelate//siroheme biosynthetic process//lysine biosynthetic process//potassium ion transport//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0043115//GO:0050661//GO:0008839//GO:0016491//GO:0051287//GO:0000166//GO:0016620 precorrin-2 dehydrogenase activity//NADP binding//4-hydroxy-tetrahydrodipicolinate reductase//oxidoreductase activity//NAD binding//nucleotide binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase Cluster-8309.35525 BF_2 62984.00 4048.30 938 556505461 YP_008757558.1 895 1.0e-93 cytochrome c oxidase subunit II (mitochondrion) [Batocera lineolata]>gi|359294284|gb|AEV21653.1| cytochrome c oxidase subunit II [Batocera lineolata] 359294281 JN986793.1 718 0 Batocera lineolata mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P98030 712 6.9e-74 Cytochrome c oxidase subunit 2 OS=Choristoneura rosaceana GN=COII PE=3 SV=1 PF02790//PF06305 Cytochrome C oxidase subunit II, transmembrane domain//Protein of unknown function (DUF1049) GO:0022900 electron transport chain -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.35526 BF_2 1099.74 21.64 2413 189235434 XP_001813433.1 2872 0.0e+00 PREDICTED: paraplegin [Tribolium castaneum]>gi|270004289|gb|EFA00737.1| hypothetical protein TcasGA2_TC003619 [Tribolium castaneum] 641666602 XM_001943555.3 54 1.04469e-16 PREDICTED: Acyrthosiphon pisum paraplegin (LOC100167726), mRNA K09552 SPG7 spastic paraplegia 7 http://www.genome.jp/dbget-bin/www_bget?ko:K09552 Q9UQ90 1641 3.3e-181 Paraplegin OS=Homo sapiens GN=SPG7 PE=1 SV=2 PF00910//PF00005//PF07724//PF00004//PF01434//PF06480//PF05496//PF06068//PF01695//PF07728 RNA helicase//ABC transporter//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Peptidase family M41//FtsH Extracellular//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily) GO:0030163//GO:0006310//GO:0006508//GO:0006281 protein catabolic process//DNA recombination//proteolysis//DNA repair GO:0003723//GO:0003678//GO:0003724//GO:0017111//GO:0009378//GO:0004222//GO:0005524//GO:0008270//GO:0016887 RNA binding//DNA helicase activity//RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//metalloendopeptidase activity//ATP binding//zinc ion binding//ATPase activity GO:0005657//GO:0009379//GO:0016021 replication fork//Holliday junction helicase complex//integral component of membrane KOG0731 AAA+-type ATPase containing the peptidase M41 domain Cluster-8309.35527 BF_2 60.68 1.63 1844 -- -- -- -- -- 642916156 XM_008192687.1 95 1.28363e-39 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35530 BF_2 6504.96 441.15 904 166947673 ABZ04123.1 542 8.3e-53 putative cuticle protein CP6 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q7M4F1 289 7.4e-25 Endocuticle structural glycoprotein SgAbd-4 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.35532 BF_2 104.56 0.49 9264 570341960 AHE77377.1 2740 1.1e-306 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 905 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2669 8.1e-300 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF01370//PF01968//PF01223//PF00033//PF04625//PF06723//PF01194//PF02491//PF08303//PF01073//PF00106//PF05739//PF02782 NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase//DNA/RNA non-specific endonuclease//Cytochrome b/b6/petB//DEC-1 protein, N-terminal region//MreB/Mbl protein//RNA polymerases N / 8 kDa subunit//SHS2 domain inserted in FTSA//tRNA ligase kinase domain//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//SNARE domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0008207//GO:0000902//GO:0005975//GO:0055114//GO:0008210//GO:0006388//GO:0022904//GO:0008152//GO:0008209//GO:0007304//GO:0007049//GO:0006694//GO:0006206//GO:0006351//GO:0006144 C21-steroid hormone metabolic process//cell morphogenesis//carbohydrate metabolic process//oxidation-reduction process//estrogen metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//metabolic process//androgen metabolic process//chorion-containing eggshell formation//cell cycle//steroid biosynthetic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0005524//GO:0003854//GO:0016616//GO:0003676//GO:0016773//GO:0046872//GO:0016491//GO:0016787//GO:0005213//GO:0050662//GO:0003899//GO:0003972//GO:0003677//GO:0003824//GO:0005515 ATP binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//metal ion binding//oxidoreductase activity//hydrolase activity//structural constituent of chorion//coenzyme binding//DNA-directed RNA polymerase activity//RNA ligase (ATP) activity//DNA binding//catalytic activity//protein binding GO:0005730//GO:0042600//GO:0016020//GO:0005576 nucleolus//chorion//membrane//extracellular region KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.35533 BF_2 580.00 140.13 460 642934836 XP_008197831.1 444 9.8e-42 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 [Tribolium castaneum]>gi|270014373|gb|EFA10821.1| hypothetical protein TcasGA2_TC030694 [Tribolium castaneum] -- -- -- -- -- K03949 NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03949 P23935 309 1.8e-27 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 OS=Bos taurus GN=NDUFA5 PE=1 SV=3 PF04716 ETC complex I subunit conserved region GO:0022904 respiratory electron transport chain GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0005743 mitochondrial inner membrane KOG3365 NADH:ubiquinone oxidoreductase, NDUFA5/B13 subunit Cluster-8309.35535 BF_2 69.01 1.50 2208 170068019 XP_001868706.1 234 1.1e-16 conserved hypothetical protein [Culex quinquefasciatus]>gi|167864133|gb|EDS27516.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00513 Late Protein L2 -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.35536 BF_2 108.86 2.37 2205 332375851 AEE63066.1 1355 1.1e-146 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01201 GBA, srfJ glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K01201 Q9UB00 931 6.5e-99 Putative glucosylceramidase 4 OS=Caenorhabditis elegans GN=gba-4 PE=3 SV=2 PF02055//PF02057 O-Glycosyl hydrolase family 30//Glycosyl hydrolase family 59 GO:0006683//GO:0006687//GO:0005975//GO:0006665//GO:0006807 galactosylceramide catabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348//GO:0004336 glucosylceramidase activity//galactosylceramidase activity -- -- KOG2566 Beta-glucocerebrosidase Cluster-8309.35537 BF_2 4761.80 83.32 2678 642934083 XP_008196496.1 1062 1.2e-112 PREDICTED: phosphatase and actin regulator 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 507 1.2e-49 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0016192//GO:0015031 vesicle-mediated transport//protein transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.35538 BF_2 32.47 0.47 3162 91076986 XP_975465.1 1098 9.8e-117 PREDICTED: SPARC [Tribolium castaneum]>gi|270001994|gb|EEZ98441.1| hypothetical protein TcasGA2_TC000930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34714 555 3.7e-55 SPARC OS=Caenorhabditis elegans GN=ost-1 PE=1 SV=1 PF10591//PF07648//PF09289//PF00713 Secreted protein acidic and rich in cysteine Ca binding region//Kazal-type serine protease inhibitor domain//Follistatin/Osteonectin-like EGF domain//Hirudin GO:0007165 signal transduction GO:0004867//GO:0005515//GO:0005509 serine-type endopeptidase inhibitor activity//protein binding//calcium ion binding GO:0005615//GO:0005578 extracellular space//proteinaceous extracellular matrix KOG4004 Matricellular protein Osteonectin/SPARC/BM-40 Cluster-8309.35542 BF_2 2013.72 43.38 2229 478262445 ENN81116.1 766 2.2e-78 hypothetical protein YQE_02484, partial [Dendroctonus ponderosae]>gi|546673666|gb|ERL85230.1| hypothetical protein D910_02651 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q08C69 452 2.3e-43 RNA pseudouridylate synthase domain-containing protein 1 OS=Danio rerio GN=rpusd1 PE=2 SV=1 PF00849 RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG1919 RNA pseudouridylate synthases Cluster-8309.35545 BF_2 272.00 11.44 1282 642936684 XP_001807897.2 430 1.1e-39 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 176 1.3e-11 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF00060//PF00520//PF04647//PF05478 Ligand-gated ion channel//Ion transport protein//Accessory gene regulator B//Prominin GO:0007165//GO:0009405//GO:0055085//GO:0007268//GO:0009372//GO:0006811 signal transduction//pathogenesis//transmembrane transport//synaptic transmission//quorum sensing//ion transport GO:0004970//GO:0005216//GO:0008233 ionotropic glutamate receptor activity//ion channel activity//peptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.35546 BF_2 469.28 5.84 3650 270009295 EFA05743.1 468 1.3e-43 serine protease H164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9LK03 168 3.2e-10 Proline-rich receptor-like protein kinase PERK2 OS=Arabidopsis thaliana GN=PERK2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35547 BF_2 240.21 5.87 2000 270016446 EFA12892.1 1585 2.1e-173 hypothetical protein TcasGA2_TC004406 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q7Z2H8 754 2.0e-78 Proton-coupled amino acid transporter 1 OS=Homo sapiens GN=SLC36A1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.35548 BF_2 47.63 0.33 6255 91076598 XP_968579.1 3094 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.22598e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 P30628 2013 6.3e-224 Probable V-type proton ATPase 116 kDa subunit a OS=Caenorhabditis elegans GN=unc-32 PE=2 SV=3 PF10417//PF03099//PF08653//PF01496 C-terminal domain of 1-Cys peroxiredoxin//Biotin/lipoate A/B protein ligase family//DASH complex subunit Dam1//V-type ATPase 116kDa subunit family GO:0008608//GO:0015992//GO:0055114//GO:0006464//GO:0015991 attachment of spindle microtubules to kinetochore//proton transport//oxidation-reduction process//cellular protein modification process//ATP hydrolysis coupled proton transport GO:0015078//GO:0051920 hydrogen ion transmembrane transporter activity//peroxiredoxin activity GO:0042729//GO:0033179//GO:0072686 DASH complex//proton-transporting V-type ATPase, V0 domain//mitotic spindle KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.35549 BF_2 268.67 2.02 5862 642935129 XP_008197899.1 458 3.0e-42 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- K14651 TAF15, NPL3 transcription initiation factor TFIID subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14651 Q27294 374 6.7e-34 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF00076//PF00641 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG1995 Conserved Zn-finger protein Cluster-8309.3555 BF_2 5.00 0.76 563 557262287 XP_006016671.1 667 1.7e-67 PREDICTED: tigger transposable element-derived protein 1-like [Alligator sinensis] -- -- -- -- -- -- -- -- -- Q96MW7 561 1.3e-56 Tigger transposable element-derived protein 1 OS=Homo sapiens GN=TIGD1 PE=1 SV=1 PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- KOG3105 DNA-binding centromere protein B (CENP-B) Cluster-8309.35550 BF_2 107.97 2.10 2437 642928513 XP_008193822.1 1402 4.3e-152 PREDICTED: uncharacterized protein LOC659984 [Tribolium castaneum] 299884466 FP926002.1 78 4.80643e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51022 606 3.5e-61 ETS-like protein pointed, isoform P1 OS=Drosophila melanogaster GN=pnt PE=2 SV=1 PF00178//PF00447//PF02198 Ets-domain//HSF-type DNA-binding//Sterile alpha motif (SAM)/Pointed domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.35551 BF_2 267.61 1.37 8432 270006792 EFA03240.1 1430 8.3e-155 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] 332376113 BT128237.1 195 1.53129e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 870 3.0e-91 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF05493//PF07994//PF00595//PF13180//PF00412 ATP synthase subunit H//Myo-inositol-1-phosphate synthase//PDZ domain (Also known as DHR or GLGF)//PDZ domain//LIM domain GO:0008654//GO:0015992//GO:0019872//GO:0015991//GO:0006021 phospholipid biosynthetic process//proton transport//streptomycin biosynthetic process//ATP hydrolysis coupled proton transport//inositol biosynthetic process GO:0015078//GO:0008270//GO:0004512//GO:0005515 hydrogen ion transmembrane transporter activity//zinc ion binding//inositol-3-phosphate synthase activity//protein binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35552 BF_2 194.76 3.19 2845 642928513 XP_008193822.1 1402 5.0e-152 PREDICTED: uncharacterized protein LOC659984 [Tribolium castaneum] 299884466 FP926002.1 78 5.61908e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51022 606 4.1e-61 ETS-like protein pointed, isoform P1 OS=Drosophila melanogaster GN=pnt PE=2 SV=1 PF02198//PF00447//PF00178 Sterile alpha motif (SAM)/Pointed domain//HSF-type DNA-binding//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.35553 BF_2 297.90 1.67 7752 642924436 XP_008194297.1 1103 6.3e-117 PREDICTED: PDZ and LIM domain protein Zasp [Tribolium castaneum] 332376113 BT128237.1 195 1.40725e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 954 4.9e-101 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF08782//PF13180//PF00412//PF15247//PF05493 PDZ domain (Also known as DHR or GLGF)//c-SKI Smad4 binding domain//PDZ domain//LIM domain//Histone RNA hairpin-binding protein RNA-binding domain//ATP synthase subunit H GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0046332//GO:0008270//GO:0015078//GO:0005515//GO:0003723 SMAD binding//zinc ion binding//hydrogen ion transmembrane transporter activity//protein binding//RNA binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.35555 BF_2 3437.68 73.49 2244 91076006 XP_966406.1 2629 2.1e-294 PREDICTED: very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014595|gb|EFA11043.1| hypothetical protein TcasGA2_TC004634 [Tribolium castaneum] 676425561 XM_009046107.1 184 5.25255e-89 Lottia gigantea hypothetical protein partial mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 Q8HXY7 1881 4.6e-209 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Macaca fascicularis GN=ACADVL PE=2 SV=1 PF02770//PF00441//PF02771 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.35557 BF_2 1532.50 52.77 1502 91080431 XP_968599.1 429 1.8e-39 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35559 BF_2 217.00 330.76 297 820969389 XP_012370642.1 498 3.5e-48 PREDICTED: LOW QUALITY PROTEIN: actin, cytoplasmic 2-like [Octodon degus] 655477108 KJ785957.1 189 1.04368e-92 Gonioctena intermedia isolate h11 beta-actin gene, partial cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 O18840 498 1.4e-49 Actin, cytoplasmic 1 OS=Canis familiaris GN=ACTB PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.35561 BF_2 22.53 0.70 1636 91086841 XP_974159.1 749 1.5e-76 PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum]>gi|642929084|ref|XP_008195684.1| PREDICTED: glutamate--cysteine ligase regulatory subunit [Tribolium castaneum] -- -- -- -- -- K11205 GCLM glutamate--cysteine ligase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11205 P48508 336 4.8e-30 Glutamate--cysteine ligase regulatory subunit OS=Rattus norvegicus GN=Gclm PE=1 SV=1 PF02020//PF00433 eIF4-gamma/eIF5/eIF2-epsilon//Protein kinase C terminal domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004674//GO:0005515//GO:0005524 protein serine/threonine kinase activity//protein binding//ATP binding -- -- KOG3023 Glutamate-cysteine ligase regulatory subunit Cluster-8309.35564 BF_2 3649.00 318.78 766 546684890 ERL94472.1 485 2.9e-46 hypothetical protein D910_11749 [Dendroctonus ponderosae] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q9D4D4 384 6.1e-36 Transketolase-like protein 2 OS=Mus musculus GN=Tktl2 PE=2 SV=1 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0523 Transketolase Cluster-8309.35565 BF_2 321.00 46.48 576 642924564 XP_008194345.1 379 4.2e-34 PREDICTED: reactive oxygen species modulator 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4QNF3 280 5.2e-24 Reactive oxygen species modulator 1 OS=Xenopus tropicalis GN=romo1 PE=3 SV=1 PF10439 Bacteriocin class II with double-glycine leader peptide GO:0042742 defense response to bacterium -- -- -- -- KOG4096 Uncharacterized conserved protein Cluster-8309.35567 BF_2 37.39 1.56 1291 642930671 XP_008199218.1 636 1.5e-63 PREDICTED: uncharacterized protein LOC100142507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35568 BF_2 157.90 7.23 1201 478250970 ENN71454.1 862 8.6e-90 hypothetical protein YQE_11872, partial [Dendroctonus ponderosae]>gi|546682661|gb|ERL92573.1| hypothetical protein D910_09886 [Dendroctonus ponderosae] -- -- -- -- -- K15143 MED30 mediator of RNA polymerase II transcription subunit 30 http://www.genome.jp/dbget-bin/www_bget?ko:K15143 Q172Y1 529 1.5e-52 Mediator of RNA polymerase II transcription subunit 30 OS=Aedes aegypti GN=MED30 PE=3 SV=1 PF03153//PF04546 Transcription factor IIA, alpha/beta subunit//Sigma-70, non-essential region GO:0006352//GO:0006367//GO:0006355 DNA-templated transcription, initiation//transcription initiation from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0016987 DNA binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667//GO:0005672 transcription factor complex//transcription factor TFIIA complex -- -- Cluster-8309.35569 BF_2 1874.31 29.08 2983 546682375 ERL92317.1 1068 2.8e-113 hypothetical protein D910_09634 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V771 749 1.1e-77 Probable cytochrome P450 6a23 OS=Drosophila melanogaster GN=Cyp6a23 PE=2 SV=2 PF00067//PF02428 Cytochrome P450//Potato type II proteinase inhibitor family GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0004867//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//serine-type endopeptidase inhibitor activity//heme binding -- -- -- -- Cluster-8309.35571 BF_2 4448.55 37.89 5198 642913457 XP_008201020.1 1887 5.2e-208 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 817221636 XM_012430865.1 450 0 PREDICTED: Orussus abietinus ankyrin repeat domain-containing protein 17 (LOC105702908), mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q9VCA8 1678 3.7e-185 Ankyrin repeat and KH domain-containing protein mask OS=Drosophila melanogaster GN=mask PE=1 SV=2 PF07650//PF00023//PF00013//PF07931//PF13606//PF13014 KH domain//Ankyrin repeat//KH domain//Chloramphenicol phosphotransferase-like protein//Ankyrin repeat//KH domain -- -- GO:0005515//GO:0005524//GO:0003723//GO:0016740 protein binding//ATP binding//RNA binding//transferase activity -- -- -- -- Cluster-8309.35572 BF_2 178.12 3.59 2363 478262468 ENN81139.1 1299 3.6e-140 hypothetical protein YQE_02506, partial [Dendroctonus ponderosae]>gi|546672781|gb|ERL84537.1| hypothetical protein D910_01967 [Dendroctonus ponderosae] -- -- -- -- -- K14689 SLC30A2, ZNT2 solute carrier family 30 (zinc transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14689 Q2HJ10 921 1.0e-97 Zinc transporter 2 OS=Mus musculus GN=Slc30a2 PE=2 SV=1 PF01545 Cation efflux family GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1482 Zn2+ transporter Cluster-8309.35573 BF_2 284.53 7.46 1883 478252002 ENN72437.1 1353 1.6e-146 hypothetical protein YQE_10928, partial [Dendroctonus ponderosae] 170066964 XM_001868258.1 142 9.78471e-66 Culex quinquefasciatus zinc finger protein, mRNA K13095 SF1 splicing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13095 Q64213 919 1.4e-97 Splicing factor 1 OS=Mus musculus GN=Sf1 PE=1 SV=6 PF00013//PF08273//PF03604//PF13014//PF00098//PF00275//PF16588 KH domain//Zinc-binding domain of primase-helicase//DNA directed RNA polymerase, 7 kDa subunit//KH domain//Zinc knuckle//EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)//C2H2 zinc-finger GO:0006351//GO:0006144//GO:0006206//GO:0006269 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//DNA replication, synthesis of RNA primer GO:0003677//GO:0003896//GO:0003723//GO:0004386//GO:0003899//GO:0003676//GO:0008270//GO:0016765 DNA binding//DNA primase activity//RNA binding//helicase activity//DNA-directed RNA polymerase activity//nucleic acid binding//zinc ion binding//transferase activity, transferring alkyl or aryl (other than methyl) groups GO:0005657//GO:0005730 replication fork//nucleolus KOG0119 Splicing factor 1/branch point binding protein (RRM superfamily) Cluster-8309.35575 BF_2 5809.84 71.44 3689 91088689 XP_974981.1 1095 2.6e-116 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 332373161 BT126760.1 197 5.15262e-96 Dendroctonus ponderosae clone DPO1116_A05 unknown mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 759 9.6e-79 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF01287//PF00560//PF13855 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//Leucine Rich Repeat//Leucine rich repeat GO:0006452//GO:0006448//GO:0045905//GO:0045901 translational frameshifting//regulation of translational elongation//positive regulation of translational termination//positive regulation of translational elongation GO:0043022//GO:0003723//GO:0005515//GO:0003746 ribosome binding//RNA binding//protein binding//translation elongation factor activity GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.35576 BF_2 2282.02 25.06 4097 189234578 XP_974655.2 1464 4.6e-159 PREDICTED: glucosidase 2 subunit beta [Tribolium castaneum] 760445822 XM_011401678.1 38 1.39838e-07 Auxenochlorella protothecoides Protein disulfide-isomerase 1 partial mRNA K13984 TXNDC5, ERP46 thioredoxin domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13984 O08795 931 1.2e-98 Glucosidase 2 subunit beta OS=Mus musculus GN=Prkcsh PE=1 SV=1 PF00578//PF13202//PF00036//PF03015//PF00085//PF00057//PF04111//PF13499//PF13405//PF04147//PF13833 AhpC/TSA family//EF hand//EF hand//Male sterility protein//Thioredoxin//Low-density lipoprotein receptor domain class A//Autophagy protein Apg6//EF-hand domain pair//EF-hand domain//Nop14-like family//EF-hand domain pair GO:0006914//GO:0055114//GO:0045454 autophagy//oxidation-reduction process//cell redox homeostasis GO:0016491//GO:0005515//GO:0005509//GO:0016209//GO:0080019 oxidoreductase activity//protein binding//calcium ion binding//antioxidant activity//fatty-acyl-CoA reductase (alcohol-forming) activity GO:0032040 small-subunit processome KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.35578 BF_2 10096.54 42.24 10287 546672491 ERL84327.1 5652 0.0e+00 hypothetical protein D910_01746, partial [Dendroctonus ponderosae] 642918533 XM_008193290.1 118 1.19076e-51 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- O01761 764 7.1e-79 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF02480 Immunoglobulin domain//Alphaherpesvirus glycoprotein E -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.35579 BF_2 552.02 17.74 1589 478252744 ENN73138.1 1260 8.1e-136 hypothetical protein YQE_10242, partial [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 946 8.6e-101 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF00287 Sodium / potassium ATPase beta chain GO:0006814//GO:0006813 sodium ion transport//potassium ion transport -- -- GO:0005890 sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.35580 BF_2 195.97 1.69 5125 642930284 XP_008196328.1 878 5.2e-91 PREDICTED: fanconi-associated nuclease 1 homolog isoform X1 [Tribolium castaneum]>gi|270010701|gb|EFA07149.1| hypothetical protein TcasGA2_TC010140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LWH4 392 4.8e-36 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF08774 VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2143 Uncharacterized conserved protein Cluster-8309.35581 BF_2 298.52 3.06 4374 189238033 XP_966902.2 1533 4.9e-167 PREDICTED: transmembrane protein 185A [Tribolium castaneum]>gi|270008773|gb|EFA05221.1| hypothetical protein TcasGA2_TC015362 [Tribolium castaneum] 642925153 XM_961809.3 270 1.60765e-136 PREDICTED: Tribolium castaneum transmembrane protein 185A (LOC655280), mRNA -- -- -- -- Q8R3R5 891 5.6e-94 Transmembrane protein 185B OS=Mus musculus GN=Tmem185b PE=2 SV=1 PF01757//PF02535 Acyltransferase family//ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0016747//GO:0046873 transferase activity, transferring acyl groups other than amino-acyl groups//metal ion transmembrane transporter activity GO:0016020 membrane KOG3907 ZIP-like zinc transporter proteins Cluster-8309.35583 BF_2 132.44 3.84 1729 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.35585 BF_2 3373.85 40.56 3767 148230813 NP_001083770.1 359 5.8e-31 microtubule-associated protein 4 [Xenopus laevis]>gi|4063005|dbj|BAA36221.1| XMAP4 [Xenopus laevis] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 O42854 189 1.2e-12 SH3 domain-containing protein C23A1.17 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC23A1.17 PE=1 SV=1 PF02730 Aldehyde ferredoxin oxidoreductase, N-terminal domain GO:0055114 oxidation-reduction process GO:0016625//GO:0051536//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//iron-sulfur cluster binding//oxidoreductase activity -- -- -- -- Cluster-8309.35586 BF_2 423.00 6.43 3041 270004722 EFA01170.1 189 2.4e-11 hypothetical protein TcasGA2_TC010493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35587 BF_2 7.18 0.54 845 332375456 AEE62869.1 570 4.4e-56 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 104 5.71593e-45 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 531 6.0e-53 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF00224 Pyruvate kinase, barrel domain GO:0006144//GO:0015976//GO:0006094//GO:0006096 purine nucleobase metabolic process//carbon utilization//gluconeogenesis//glycolytic process GO:0000287//GO:0004743//GO:0030955 magnesium ion binding//pyruvate kinase activity//potassium ion binding -- -- KOG2323 Pyruvate kinase Cluster-8309.35588 BF_2 40.77 1.20 1713 642935906 XP_008198223.1 2115 6.3e-235 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 768415454 XM_011549976.1 627 0 PREDICTED: Plutella xylostella calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC105380420), transcript variant X5, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2015 1.0e-224 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35590 BF_2 6289.41 982.06 555 264667323 ACY71247.1 756 7.8e-78 ribosomal protein S13 [Chrysomela tremula] 26190492 AY174891.1 124 2.79875e-56 Plutella xylostella ribosomal protein S13 mRNA, complete cds K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 Q962R6 713 3.1e-74 40S ribosomal protein S13 OS=Spodoptera frugiperda GN=RpS13 PE=2 SV=3 PF08069//PF00312 Ribosomal S13/S15 N-terminal domain//Ribosomal protein S15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0400 40S ribosomal protein S13 Cluster-8309.35591 BF_2 3109.23 22.85 5979 270004228 EFA00676.1 1956 6.0e-216 hypothetical protein TcasGA2_TC003553 [Tribolium castaneum] 642916460 XM_008192815.1 144 2.43176e-66 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58006 1177 5.3e-127 Sestrin-1 OS=Mus musculus GN=Sesn1 PE=2 SV=3 PF04636//PF08683 PA26 p53-induced protein (sestrin)//Microtubule-binding calmodulin-regulated spectrin-associated GO:1901031 regulation of response to reactive oxygen species GO:0008017 microtubule binding GO:0045298//GO:0005634 tubulin complex//nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.35592 BF_2 134.91 3.86 1749 332376705 AEE63492.1 543 1.2e-52 unknown [Dendroctonus ponderosae] 332376704 BT128535.1 250 8.33657e-126 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 450 3.1e-43 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF09416//PF00992 RNA helicase (UPF2 interacting domain)//Troponin GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0003677//GO:0008270//GO:0005524//GO:0004386 DNA binding//zinc ion binding//ATP binding//helicase activity GO:0005737//GO:0005861 cytoplasm//troponin complex KOG3977 Troponin I Cluster-8309.35594 BF_2 77.28 28.58 399 478257467 ENN77623.1 324 6.9e-28 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] -- -- -- -- -- K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9M4G4 268 8.9e-23 Phosphoglucomutase, cytoplasmic OS=Solanum tuberosum GN=PGM1 PE=2 SV=1 PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0005975 carbohydrate metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG0625 Phosphoglucomutase Cluster-8309.35596 BF_2 513.37 9.80 2479 478251025 ENN71506.1 1061 1.5e-112 hypothetical protein YQE_11799, partial [Dendroctonus ponderosae]>gi|546679474|gb|ERL89938.1| hypothetical protein D910_07297 [Dendroctonus ponderosae] -- -- -- -- -- K10052 CEBPN CCAAT/enhancer binding protein (C/EBP), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K10052 Q02637 261 3.6e-21 CCAAT/enhancer-binding protein OS=Drosophila melanogaster GN=slbo PE=1 SV=3 PF00170//PF07716//PF11023//PF04960 bZIP transcription factor//Basic region leucine zipper//Zinc-ribbon containing domain//Glutaminase GO:0006355//GO:0006541 regulation of transcription, DNA-templated//glutamine metabolic process GO:0043565//GO:0004359//GO:0003700 sequence-specific DNA binding//glutaminase activity//transcription factor activity, sequence-specific DNA binding GO:0005887//GO:0005667 integral component of plasma membrane//transcription factor complex -- -- Cluster-8309.35599 BF_2 283.97 161.25 357 741829858 AJA91073.1 464 3.6e-44 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 352 1.5e-32 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.356 BF_2 9.00 2.17 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35600 BF_2 10481.60 777.65 851 332376312 AEE63296.1 687 1.2e-69 unknown [Dendroctonus ponderosae] 332376311 BT128338.1 35 1.30971e-06 Dendroctonus ponderosae clone DPO1410_H07 unknown mRNA -- -- -- -- Q00649 201 1.1e-14 Heat shock protein beta-1 OS=Gallus gallus GN=HSPB1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.35601 BF_2 255.00 16.94 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35603 BF_2 755.11 6.30 5301 642936172 XP_008198327.1 3060 0.0e+00 PREDICTED: arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 [Tribolium castaneum]>gi|270014057|gb|EFA10505.1| hypothetical protein TcasGA2_TC012753 [Tribolium castaneum] -- -- -- -- -- K12489 ACAP Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12489 Q6IVG4 1615 7.6e-178 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 OS=Oryctolagus cuniculus GN=ACAP2 PE=2 SV=1 PF01412//PF00023//PF03114//PF13606//PF02170 Putative GTPase activating protein for Arf//Ankyrin repeat//BAR domain//Ankyrin repeat//PAZ domain -- -- GO:0005515//GO:0005543//GO:0005096//GO:0008270//GO:0019904 protein binding//phospholipid binding//GTPase activator activity//zinc ion binding//protein domain specific binding GO:0005737 cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.35604 BF_2 7122.38 250.83 1475 91090290 XP_971485.1 977 4.9e-103 PREDICTED: bax inhibitor 1 [Tribolium castaneum]>gi|270013796|gb|EFA10244.1| hypothetical protein TcasGA2_TC012443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7R1 591 1.2e-59 Bax inhibitor 1 OS=Pongo abelii GN=TMBIM6 PE=2 SV=2 -- -- GO:0043066 negative regulation of apoptotic process -- -- GO:0016021 integral component of membrane KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-8309.35605 BF_2 691.92 12.19 2662 91088615 XP_974002.1 834 3.4e-86 PREDICTED: sepiapterin reductase [Tribolium castaneum]>gi|270012265|gb|EFA08713.1| hypothetical protein TcasGA2_TC006384 [Tribolium castaneum] -- -- -- -- -- K00072 SPR sepiapterin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00072 P35270 313 3.6e-27 Sepiapterin reductase OS=Homo sapiens GN=SPR PE=1 SV=1 PF05130//PF12242//PF00769//PF00106 FlgN protein//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Ezrin/radixin/moesin family//short chain dehydrogenase GO:0055114//GO:0008152//GO:0044780 oxidation-reduction process//metabolic process//bacterial-type flagellum assembly GO:0016491//GO:0008092 oxidoreductase activity//cytoskeletal protein binding GO:0005737//GO:0019898 cytoplasm//extrinsic component of membrane KOG1204 Predicted dehydrogenase Cluster-8309.35606 BF_2 1005.00 39.97 1339 270013242 EFA09690.1 1424 6.6e-155 hypothetical protein TcasGA2_TC011818 [Tribolium castaneum] -- -- -- -- -- K02257 COX10 protoheme IX farnesyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02257 Q8CFY5 809 5.5e-85 Protoheme IX farnesyltransferase, mitochondrial OS=Mus musculus GN=Cox10 PE=2 SV=1 PF01040 UbiA prenyltransferase family -- -- GO:0004659 prenyltransferase activity GO:0016021 integral component of membrane KOG1380 Heme A farnesyltransferase Cluster-8309.35607 BF_2 612.33 5.09 5320 642919164 XP_008191764.1 1586 4.3e-173 PREDICTED: forkhead box protein N3-like isoform X2 [Tribolium castaneum] 642919163 XM_008193542.1 45 2.33709e-11 PREDICTED: Tribolium castaneum forkhead box protein N3-like (LOC100141565), transcript variant X5, mRNA K09407 FOXN forkhead box protein N http://www.genome.jp/dbget-bin/www_bget?ko:K09407 Q499D0 451 7.2e-43 Forkhead box protein N3 OS=Mus musculus GN=Foxn3 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.35608 BF_2 307.47 6.85 2166 642918239 XP_008191425.1 661 3.2e-66 PREDICTED: protein enabled isoform X2 [Tribolium castaneum] 642918238 XM_008193203.1 203 1.38904e-99 PREDICTED: Tribolium castaneum protein enabled (LOC658784), transcript variant X2, mRNA K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 463 1.2e-44 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 PF12235//PF00638 Fragile X-related 1 protein core C terminal//RanBP1 domain GO:0046907 intracellular transport GO:0003723 RNA binding -- -- KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.35609 BF_2 2262.66 35.52 2952 332374224 AEE62253.1 1574 5.8e-172 unknown [Dendroctonus ponderosae] 662188737 XM_008489835.1 98 4.44593e-41 PREDICTED: Diaphorina citri elongation factor Tu, mitochondrial (LOC103524802), mRNA K02358 tuf, TUFM elongation factor Tu http://www.genome.jp/dbget-bin/www_bget?ko:K02358 P49411 1138 8.7e-123 Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 PF00231//PF02602//PF00894//PF01926//PF05165//PF03144 ATP synthase//Uroporphyrinogen-III synthase HemD//Luteovirus coat protein//50S ribosome-binding GTPase//GTP cyclohydrolase III//Elongation factor Tu domain 2 GO:0033014//GO:0015994//GO:0006119//GO:0006807//GO:0006783//GO:0015986//GO:0009058//GO:0015992 tetrapyrrole biosynthetic process//chlorophyll metabolic process//oxidative phosphorylation//nitrogen compound metabolic process//heme biosynthetic process//ATP synthesis coupled proton transport//biosynthetic process//proton transport GO:0003933//GO:0005525//GO:0005198//GO:0004852//GO:0046961//GO:0046933 GTP cyclohydrolase activity//GTP binding//structural molecule activity//uroporphyrinogen-III synthase activity//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045261//GO:0045259//GO:0019028 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//viral capsid KOG0460 Mitochondrial translation elongation factor Tu Cluster-8309.35610 BF_2 4166.98 147.62 1468 332372901 AEE61592.1 1248 1.8e-134 unknown [Dendroctonus ponderosae]>gi|478260309|gb|ENN80061.1| hypothetical protein YQE_03537, partial [Dendroctonus ponderosae]>gi|546678011|gb|ERL88735.1| hypothetical protein D910_06117 [Dendroctonus ponderosae] 859814967 XM_013059117.1 74 4.79826e-28 PREDICTED: Mustela putorius furo ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1 (ATP5C1), transcript variant X5, mRNA K02136 ATPeF1G, ATP5C1, ATP3 F-type H+-transporting ATPase subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K02136 O01666 1060 4.8e-114 ATP synthase subunit gamma, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-gamma PE=2 SV=2 PF00231//PF00894//PF02602//PF05165 ATP synthase//Luteovirus coat protein//Uroporphyrinogen-III synthase HemD//GTP cyclohydrolase III GO:0015992//GO:0009058//GO:0033014//GO:0006119//GO:0015994//GO:0015986//GO:0006783//GO:0006807 proton transport//biosynthetic process//tetrapyrrole biosynthetic process//oxidative phosphorylation//chlorophyll metabolic process//ATP synthesis coupled proton transport//heme biosynthetic process//nitrogen compound metabolic process GO:0005198//GO:0046933//GO:0004852//GO:0046961//GO:0003933 structural molecule activity//proton-transporting ATP synthase activity, rotational mechanism//uroporphyrinogen-III synthase activity//proton-transporting ATPase activity, rotational mechanism//GTP cyclohydrolase activity GO:0019028//GO:0045259//GO:0045261 viral capsid//proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1531 F0F1-type ATP synthase, gamma subunit Cluster-8309.35614 BF_2 486.97 31.01 944 91081971 XP_967978.1 413 7.9e-38 PREDICTED: plexin domain-containing protein 2 [Tribolium castaneum]>gi|270007319|gb|EFA03767.1| hypothetical protein TcasGA2_TC013878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91ZV7 242 2.2e-19 Plexin domain-containing protein 1 OS=Mus musculus GN=Plxdc1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-8309.35615 BF_2 28.83 0.80 1791 270008621 EFA05069.1 153 2.1e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35618 BF_2 1428.00 67.21 1176 270002311 EEZ98758.1 803 5.9e-83 hypothetical protein TcasGA2_TC001322 [Tribolium castaneum] -- -- -- -- -- K17795 TIM17 mitochondrial import inner membrane translocase subunit TIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17795 O60830 597 1.9e-60 Mitochondrial import inner membrane translocase subunit Tim17-B OS=Homo sapiens GN=TIMM17B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1652 Mitochondrial import inner membrane translocase, subunit TIM17 Cluster-8309.35619 BF_2 602.62 17.69 1712 91084399 XP_966650.1 835 1.7e-86 PREDICTED: protein FAM57A isoform X1 [Tribolium castaneum]>gi|270008835|gb|EFA05283.1| hypothetical protein TcasGA2_TC015440 [Tribolium castaneum] 194890120 XM_001977204.1 49 4.43398e-14 Drosophila erecta GG18353 (Dere\GG18353), mRNA -- -- -- -- Q5ND56 258 5.5e-21 Protein FAM57A OS=Mus musculus GN=Fam57a PE=3 SV=1 PF03798 TLC domain -- -- -- -- GO:0016021 integral component of membrane KOG4561 Uncharacterized conserved protein, contains TBC domain Cluster-8309.3562 BF_2 11.00 0.35 1592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35620 BF_2 2725.08 69.39 1930 150416589 ABF60888.2 211 4.3e-14 putative glycine-rich protein [Leptinotarsa decemlineata]>gi|157649942|gb|ABV59365.1| glycine-rich protein variant 2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.35621 BF_2 239.00 20.54 774 765151967 XP_011486295.1 155 5.3e-08 PREDICTED: low-density lipoprotein receptor-related protein 2-like isoform X1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- A2ARV4 149 1.1e-08 Low-density lipoprotein receptor-related protein 2 OS=Mus musculus GN=Lrp2 PE=1 SV=1 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.35623 BF_2 588.18 10.18 2704 91087669 XP_973734.1 622 1.3e-61 PREDICTED: myosin-2 essential light chain isoform X2 [Tribolium castaneum]>gi|270009413|gb|EFA05861.1| hypothetical protein TcasGA2_TC008661 [Tribolium castaneum] 642930376 XM_968641.2 139 6.57032e-64 PREDICTED: Tribolium castaneum myosin-2 essential light chain (LOC662551), transcript variant X2, mRNA K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 P54357 537 3.9e-53 Myosin-2 essential light chain OS=Drosophila melanogaster GN=Mlc-c PE=1 SV=1 PF13499//PF13833//PF00036//PF13405//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.35624 BF_2 458.00 13.09 1751 546684978 ERL94552.1 643 3.1e-64 hypothetical protein D910_11829 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35626 BF_2 216.68 4.89 2141 91080237 XP_972872.1 868 3.1e-90 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35627 BF_2 117.00 0.74 6920 270003816 EFA00264.1 225 3.7e-15 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04060//PF07975//PF13465//PF04777//PF16622//PF13912//PF01363//PF00412//PF02892//PF00096//PF02176//PF14634//PF00643 Putative Fe-S cluster//TFIIH C1-like domain//Zinc-finger double domain//Erv1 / Alr family//zinc-finger C2H2-type//C2H2-type zinc finger//FYVE zinc finger//LIM domain//BED zinc finger//Zinc finger, C2H2 type//TRAF-type zinc finger//zinc-RING finger domain//B-box zinc finger GO:0055114//GO:0006281 oxidation-reduction process//DNA repair GO:0046872//GO:0016972//GO:0008270//GO:0051536//GO:0005515//GO:0003677 metal ion binding//thiol oxidase activity//zinc ion binding//iron-sulfur cluster binding//protein binding//DNA binding GO:0005622 intracellular -- -- Cluster-8309.35628 BF_2 1565.00 79.85 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35629 BF_2 410.07 11.78 1743 91078980 XP_974492.1 1933 8.1e-214 PREDICTED: cyclin-dependent kinase 10 [Tribolium castaneum]>gi|270004165|gb|EFA00613.1| hypothetical protein TcasGA2_TC003488 [Tribolium castaneum] 642916245 XM_969399.2 355 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 10 (LOC663347), mRNA K02449 CDK10 cyclin-dependent kinase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K02449 Q3UMM4 1335 7.3e-146 Cyclin-dependent kinase 10 OS=Mus musculus GN=Cdk10 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.35630 BF_2 189.00 1.74 4843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.35631 BF_2 367.96 7.95 2224 642924941 XP_967306.2 1340 6.0e-145 PREDICTED: uncharacterized protein LOC658255 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53184 285 5.3e-24 Nicotinamidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNC1 PE=1 SV=1 PF00036//PF13202//PF00857//PF13499//PF13833//PF10591//PF13405//PF12763 EF hand//EF hand//Isochorismatase family//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Cytoskeletal-regulatory complex EF hand GO:0008152//GO:0007165 metabolic process//signal transduction GO:0005515//GO:0003824//GO:0005509 protein binding//catalytic activity//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4003 Pyrazinamidase/nicotinamidase PNC1 Cluster-8309.35633 BF_2 33.87 0.36 4243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01386 Ribosomal L25p family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0008097 structural constituent of ribosome//5S rRNA binding GO:0005840 ribosome -- -- Cluster-8309.35637 BF_2 44.55 0.86 2457 270010228 EFA06676.1 389 1.2e-34 hypothetical protein TcasGA2_TC009606 [Tribolium castaneum] 366039975 NM_001256069.1 128 7.77279e-58 Tribolium castaneum ornithine decarboxylase antizyme az (az), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35638 BF_2 38.96 1.21 1639 642934668 XP_008197760.1 1558 2.3e-170 PREDICTED: nuclear receptor-binding protein homolog [Tribolium castaneum] 642934667 XM_008199538.1 438 0 PREDICTED: Tribolium castaneum nuclear receptor-binding protein homolog (LOC661173), mRNA K08875 NRBP nuclear receptor-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08875 Q99J45 1060 5.3e-114 Nuclear receptor-binding protein OS=Mus musculus GN=Nrbp1 PE=1 SV=1 PF01365//PF07714//PF00069 RIH domain//Protein tyrosine kinase//Protein kinase domain GO:0006816//GO:0070588//GO:0006468 calcium ion transport//calcium ion transmembrane transport//protein phosphorylation GO:0005524//GO:0005262//GO:0004672 ATP binding//calcium channel activity//protein kinase activity GO:0016020 membrane KOG1266 Protein kinase Cluster-8309.35639 BF_2 1238.96 27.82 2150 607303042 EZA44934.1 957 1.5e-100 Zinc-finger C2H2 domain and EB module-containing protein [Microplitis demolitor] -- -- -- -- -- -- -- -- -- Q6ZMW2 404 8.2e-38 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF16622//PF07776//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.3564 BF_2 3.00 0.66 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35640 BF_2 12.27 0.41 1530 642913599 XP_008201080.1 169 2.5e-09 PREDICTED: extensin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35641 BF_2 773.63 11.47 3109 225543476 NP_001139385.1 1555 9.8e-170 ventral vein lacking [Tribolium castaneum]>gi|270008227|gb|EFA04675.1| ventral veins lacking [Tribolium castaneum] 225543475 NM_001145913.1 483 0 Tribolium castaneum ventral vein lacking (Vvl), mRNA K09365 POU3F, OTF POU domain transcription factor, class 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09365 P16241 1007 1.4e-107 POU domain protein CF1A OS=Drosophila melanogaster GN=vvl PE=2 SV=5 PF00046//PF00157//PF05920 Homeobox domain//Pou domain - N-terminal to homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.35642 BF_2 13086.30 56.94 9902 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 5.52395e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF03184//PF05225//PF04545//PF02796//PF01180//PF00196//PF00070//PF04218//PF01704//PF07992//PF01593//PF01884//PF06574//PF01207 DDE superfamily endonuclease//helix-turn-helix, Psq domain//Sigma-70, region 4//Helix-turn-helix domain of resolvase//Dihydroorotate dehydrogenase//Bacterial regulatory proteins, luxR family//Pyridine nucleotide-disulphide oxidoreductase//CENP-B N-terminal DNA-binding domain//UTP--glucose-1-phosphate uridylyltransferase//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//PcrB family//FAD synthetase//Dihydrouridine synthase (Dus) GO:0006207//GO:0055114//GO:0008033//GO:0006355//GO:0006118//GO:0009231//GO:0006222//GO:0008152//GO:0006352//GO:0006310//GO:0006771//GO:0006206 'de novo' pyrimidine nucleobase biosynthetic process//oxidation-reduction process//tRNA processing//regulation of transcription, DNA-templated//obsolete electron transport//riboflavin biosynthetic process//UMP biosynthetic process//metabolic process//DNA-templated transcription, initiation//DNA recombination//riboflavin metabolic process//pyrimidine nucleobase metabolic process GO:0000150//GO:0070569//GO:0016765//GO:0003700//GO:0016627//GO:0003919//GO:0051536//GO:0017150//GO:0016491//GO:0004158//GO:0003677//GO:0009055//GO:0016987//GO:0003676//GO:0050660 recombinase activity//uridylyltransferase activity//transferase activity, transferring alkyl or aryl (other than methyl) groups//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//FMN adenylyltransferase activity//iron-sulfur cluster binding//tRNA dihydrouridine synthase activity//oxidoreductase activity//dihydroorotate oxidase activity//DNA binding//electron carrier activity//sigma factor activity//nucleic acid binding//flavin adenine dinucleotide binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.35643 BF_2 319.00 17.05 1070 -- -- -- -- -- 642911838 XM_008202546.1 52 5.88934e-16 PREDICTED: Tribolium castaneum endophilin-A (LOC661913), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35644 BF_2 2655.04 12.04 9514 642930211 XP_008196303.1 2794 0.0e+00 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.44118e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1693 1.2e-186 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF02230//PF02171//PF04636//PF07859//PF09494//PF15384//PF01764//PF02170//PF02186 Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin)//alpha/beta hydrolase fold//Slx4 endonuclease//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//Lipase (class 3)//PAZ domain//TFIIE beta subunit core domain GO:0006260//GO:0006308//GO:0006367//GO:1901031//GO:0008152//GO:0006303//GO:0006281//GO:0006629 DNA replication//DNA catabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species//metabolic process//double-strand break repair via nonhomologous end joining//DNA repair//lipid metabolic process GO:0003676//GO:0016787//GO:0005515//GO:0017108 nucleic acid binding//hydrolase activity//protein binding//5'-flap endonuclease activity GO:0033557//GO:0005634 Slx1-Slx4 complex//nucleus KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.35650 BF_2 2912.49 32.41 4046 642934871 XP_008197844.1 2971 0.0e+00 PREDICTED: ecdysone-inducible protein E75 isoform X2 [Tribolium castaneum] 642934870 XM_008199622.1 588 0 PREDICTED: Tribolium castaneum ecdysone-inducible protein E75 (LOC660005), transcript variant X2, mRNA K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1750 1.3e-193 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.35653 BF_2 101.95 1.09 4213 91078690 XP_971137.1 2336 3.7e-260 PREDICTED: eukaryotic translation initiation factor 3 subunit L [Tribolium castaneum]>gi|270003761|gb|EFA00209.1| hypothetical protein TcasGA2_TC003034 [Tribolium castaneum] -- -- -- -- -- K15029 EIF3L translation initiation factor 3 subunit L http://www.genome.jp/dbget-bin/www_bget?ko:K15029 Q16FL6 1819 1.3e-201 Eukaryotic translation initiation factor 3 subunit L OS=Aedes aegypti GN=AAEL009617 PE=3 SV=1 PF10255//PF07668 RNA polymerase I-associated factor PAF67//M penetrans paralogue family 1 GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005737//GO:0005852//GO:0016020//GO:0005840 cytoplasm//eukaryotic translation initiation factor 3 complex//membrane//ribosome KOG4197 FOG: PPR repeat Cluster-8309.35654 BF_2 9953.00 66.07 6589 642919151 XP_008191758.1 6970 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 884968689 XM_013138180.1 39 6.27092e-08 PREDICTED: Esox lucius low-density lipoprotein receptor-related protein 1-like (LOC105017034), mRNA -- -- -- -- O88307 2465 2.6e-276 Sortilin-related receptor OS=Mus musculus GN=Sorl1 PE=1 SV=3 PF00057//PF05196//PF00041//PF01445 Low-density lipoprotein receptor domain class A//PTN/MK heparin-binding protein family, N-terminal domain//Fibronectin type III domain//Viral small hydrophobic protein GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083//GO:0005515 growth factor activity//protein binding GO:0016020 membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.35655 BF_2 433.18 8.18 2503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02260//PF00724 FATC domain//NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0005515//GO:0016491//GO:0010181 protein binding//oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.35656 BF_2 936.00 8.54 4873 332376432 AEE63356.1 1763 1.2e-193 unknown [Dendroctonus ponderosae]>gi|478260884|gb|ENN80521.1| hypothetical protein YQE_03060, partial [Dendroctonus ponderosae] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q6GMK8 1320 1.1e-143 Mannose-1-phosphate guanyltransferase alpha-A OS=Danio rerio GN=gmppaa PE=2 SV=1 PF10584//PF00795//PF00483 Proteasome subunit A N-terminal signature//Carbon-nitrogen hydrolase//Nucleotidyl transferase GO:0009058//GO:0006807//GO:0006511 biosynthetic process//nitrogen compound metabolic process//ubiquitin-dependent protein catabolic process GO:0004175//GO:0016779//GO:0016810 endopeptidase activity//nucleotidyltransferase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0019773 proteasome core complex, alpha-subunit complex KOG1460 GDP-mannose pyrophosphorylase Cluster-8309.35657 BF_2 437.30 22.67 1094 91083531 XP_973193.1 847 4.3e-88 PREDICTED: carbonyl reductase [NADPH] 1 [Tribolium castaneum]>gi|270010851|gb|EFA07299.1| hypothetical protein TcasGA2_TC014539 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q8K354 481 4.9e-47 Carbonyl reductase [NADPH] 3 OS=Mus musculus GN=Cbr3 PE=2 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.35659 BF_2 537.06 11.31 2274 91078870 XP_972519.1 2156 1.5e-239 PREDICTED: peptide transporter family 1-like [Tribolium castaneum] 462304202 APGK01049574.1 91 2.65854e-37 Dendroctonus ponderosae Seq01049584, whole genome shotgun sequence K14206 SLC15A1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14206 P91679 1400 2.8e-153 Peptide transporter family 1 OS=Drosophila melanogaster GN=yin PE=1 SV=2 PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1237 H+/oligopeptide symporter Cluster-8309.35660 BF_2 64.00 3.60 1030 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35661 BF_2 15178.17 559.99 1421 642936715 XP_008198550.1 1108 3.1e-118 PREDICTED: 60S ribosomal protein L5 [Tribolium castaneum]>gi|270000965|gb|EEZ97412.1| hypothetical protein TcasGA2_TC011241 [Tribolium castaneum] 665810153 XM_008555260.1 161 2.01172e-76 PREDICTED: Microplitis demolitor 60S ribosomal protein L5 (LOC103575464), mRNA K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 O76190 994 2.1e-106 60S ribosomal protein L5 OS=Bombyx mori GN=RpL5 PE=2 SV=1 PF00861 Ribosomal L18p/L5e family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0875 60S ribosomal protein L5 Cluster-8309.35662 BF_2 1928.62 21.91 3970 91084587 XP_974100.1 2483 3.1e-277 PREDICTED: zinc finger FYVE domain-containing protein 9 [Tribolium castaneum]>gi|270008651|gb|EFA05099.1| hypothetical protein TcasGA2_TC015198 [Tribolium castaneum] -- -- -- -- -- K04679 MADHIP, SARA MAD, mothers against decapentaplegic interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K04679 O95405 1357 4.7e-148 Zinc finger FYVE domain-containing protein 9 OS=Homo sapiens GN=ZFYVE9 PE=1 SV=2 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1841 Smad anchor for receptor activation Cluster-8309.35663 BF_2 140.94 0.67 9061 642920471 XP_008192365.1 3497 0.0e+00 PREDICTED: CREB-binding protein isoform X6 [Tribolium castaneum] 170039953 XM_001847729.1 703 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2346 2.2e-262 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF08214//PF09030//PF02135//PF02172//PF16987//PF09468//PF07711//PF00569//PF12437//PF00439 Histone acetylation protein//Creb binding//TAZ zinc finger//KIX domain//KIX domain//Ydr279p protein family (RNase H2 complex component)//Rab geranylgeranyl transferase alpha-subunit, insert domain//Zinc finger, ZZ type//Glutamine synthetase type III N terminal//Bromodomain GO:0009252//GO:0006807//GO:0016573//GO:0042967//GO:0006355 peptidoglycan biosynthetic process//nitrogen compound metabolic process//histone acetylation//acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0004356//GO:0003713//GO:0005515//GO:0004402//GO:0008270//GO:0003712//GO:0004663 glutamate-ammonia ligase activity//transcription coactivator activity//protein binding//histone acetyltransferase activity//zinc ion binding//transcription cofactor activity//Rab geranylgeranyltransferase activity GO:0005634//GO:0005968//GO:0005667//GO:0000123 nucleus//Rab-protein geranylgeranyltransferase complex//transcription factor complex//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.35665 BF_2 69.84 0.77 4072 751229541 XP_011168238.1 1136 5.0e-121 PREDICTED: REST corepressor isoform X3 [Solenopsis invicta] 817199620 XM_012420083.1 130 1.00098e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q59E36 809 1.7e-84 REST corepressor OS=Drosophila melanogaster GN=CoRest PE=1 SV=2 PF00376 MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.35666 BF_2 137.02 1.45 4248 478251222 ENN71696.1 1228 1.1e-131 hypothetical protein YQE_11619, partial [Dendroctonus ponderosae] 315115388 HQ424723.1 158 2.84346e-74 Euphydryas aurinia ribosomal protein S15 (RpS15) mRNA, complete cds K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 Q9W6S3 537 6.1e-53 Target of rapamycin complex 2 subunit MAPKAP1 OS=Gallus gallus GN=MAPKAP1 PE=2 SV=1 PF04145//PF00203 Ctr copper transporter family//Ribosomal protein S19 GO:0006412//GO:0006825//GO:0035434//GO:0042254 translation//copper ion transport//copper ion transmembrane transport//ribosome biogenesis GO:0003735//GO:0005375 structural constituent of ribosome//copper ion transmembrane transporter activity GO:0016021//GO:0005840 integral component of membrane//ribosome KOG0898 40S ribosomal protein S15 Cluster-8309.35667 BF_2 906.00 16.53 2580 91081423 XP_973326.1 1015 3.4e-107 PREDICTED: eukaryotic translation initiation factor 3 subunit K [Tribolium castaneum]>gi|270005163|gb|EFA01611.1| hypothetical protein TcasGA2_TC007178 [Tribolium castaneum] -- -- -- -- -- K15028 EIF3K translation initiation factor 3 subunit K http://www.genome.jp/dbget-bin/www_bget?ko:K15028 Q1HPS4 805 3.1e-84 Eukaryotic translation initiation factor 3 subunit K OS=Bombyx mori PE=2 SV=1 PF09421//PF00957//PF05739//PF03530 Frequency clock protein//Synaptobrevin//SNARE domain//Calcium-activated SK potassium channel GO:0006355//GO:0006813//GO:0007623//GO:0016192//GO:0006446 regulation of transcription, DNA-templated//potassium ion transport//circadian rhythm//vesicle-mediated transport//regulation of translational initiation GO:0016286//GO:0005515//GO:0003743//GO:0043022 small conductance calcium-activated potassium channel activity//protein binding//translation initiation factor activity//ribosome binding GO:0005852//GO:0005737//GO:0005840//GO:0005634//GO:0016021 eukaryotic translation initiation factor 3 complex//cytoplasm//ribosome//nucleus//integral component of membrane KOG3252 Uncharacterized conserved protein Cluster-8309.35669 BF_2 4663.99 194.75 1289 264667397 ACY71284.1 327 1.0e-27 ribosomal protein L37 [Chrysomela tremula] 70909882 AM049128.1 111 1.13488e-48 Sphaerius sp. APV-2005 mRNA for ribosomal protein L37e (rpL37e gene) K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q962S7 298 9.6e-26 60S ribosomal protein L37 OS=Spodoptera frugiperda GN=RpL37 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3475 60S ribosomal protein L37 Cluster-8309.35673 BF_2 5.00 3.23 347 635090844 XP_008010096.1 292 3.1e-24 PREDICTED: 60S ribosomal protein L38 isoform X3 [Chlorocebus sabaeus] 78214520 NM_000999.3 347 1.82884e-180 Homo sapiens ribosomal protein L38 (RPL38), transcript variant 1, mRNA K02923 RP-L38e, RPL38 large subunit ribosomal protein L38e http://www.genome.jp/dbget-bin/www_bget?ko:K02923 P63173 236 4.0e-19 60S ribosomal protein L38 OS=Homo sapiens GN=RPL38 PE=1 SV=2 PF01781 Ribosomal L38e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3499 60S ribosomal protein L38 Cluster-8309.35675 BF_2 395.13 2.75 6305 332375504 AEE62893.1 1136 7.7e-121 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 7.4e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF02183//PF07850//PF15898//PF12474//PF04111//PF01166//PF16944 Homeobox associated leucine zipper//Renin receptor-like protein//cGMP-dependent protein kinase interacting domain//Polo kinase kinase//Autophagy protein Apg6//TSC-22/dip/bun family//Fungal potassium channel GO:0009069//GO:0006914//GO:0007165//GO:0006355//GO:0006813//GO:0071805//GO:0016310 serine family amino acid metabolic process//autophagy//signal transduction//regulation of transcription, DNA-templated//potassium ion transport//potassium ion transmembrane transport//phosphorylation GO:0015079//GO:0003700//GO:0004674//GO:0043565//GO:0019901//GO:0004872 potassium ion transmembrane transporter activity//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity//sequence-specific DNA binding//protein kinase binding//receptor activity GO:0016021//GO:0005887//GO:0005667 integral component of membrane//integral component of plasma membrane//transcription factor complex KOG4001 Axonemal dynein light chain Cluster-8309.35677 BF_2 491.18 13.93 1762 332376075 AEE63178.1 1140 7.4e-122 unknown [Dendroctonus ponderosae] 820864294 XM_003698316.2 303 2.89555e-155 PREDICTED: Apis florea MOB kinase activator-like 1 (LOC100870844), transcript variant X2, mRNA K06685 MOB1, Mats MOB kinase activator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06685 Q95RA8 1073 1.8e-115 MOB kinase activator-like 1 OS=Drosophila melanogaster GN=mats PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.35679 BF_2 954.00 14.47 3046 -- -- -- -- -- 642919818 XM_008193860.1 102 2.74254e-43 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X7, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35680 BF_2 381.00 21.23 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140//PF04625 Crustacean cuticle protein repeat//DEC-1 protein, N-terminal region GO:0007304 chorion-containing eggshell formation GO:0005213//GO:0042302 structural constituent of chorion//structural constituent of cuticle GO:0005576//GO:0042600 extracellular region//chorion -- -- Cluster-8309.35681 BF_2 3677.00 142.31 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35682 BF_2 1727.00 46.32 1847 642934891 XP_971764.2 1071 7.8e-114 PREDICTED: retinol dehydrogenase 14 [Tribolium castaneum] -- -- -- -- -- K11162 RDH14 retinol dehydrogenase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K11162 Q9ERI6 664 5.0e-68 Retinol dehydrogenase 14 OS=Mus musculus GN=Rdh14 PE=2 SV=1 PF02826//PF01370//PF03435//PF00106//PF01073 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0008210//GO:0008152 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0016491//GO:0016616//GO:0051287//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- -- -- Cluster-8309.35684 BF_2 45.32 0.49 4187 642915851 XP_008196212.1 427 8.3e-39 PREDICTED: gamma-glutamyl hydrolase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 283 1.7e-23 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722 Peptidase C26 GO:0006541 glutamine metabolic process GO:0016787 hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.35686 BF_2 63.51 1.77 1785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35687 BF_2 48.78 0.56 3953 270004149 EFA00597.1 615 1.2e-60 hypothetical protein TcasGA2_TC003468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35688 BF_2 437.00 5.15 3836 91088687 XP_974969.1 1899 1.6e-209 PREDICTED: COP9 signalosome complex subunit 4 [Tribolium castaneum]>gi|270011671|gb|EFA08119.1| hypothetical protein TcasGA2_TC005723 [Tribolium castaneum] 749787628 XM_011149029.1 221 2.44138e-109 PREDICTED: Harpegnathos saltator COP9 signalosome complex subunit 4 (LOC105187902), mRNA K12178 COPS4, CSN4 COP9 signalosome complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12178 Q6P0H6 1564 4.5e-172 COP9 signalosome complex subunit 4 OS=Danio rerio GN=cops4 PE=2 SV=1 PF13202//PF13176//PF02733//PF01399//PF00036//PF13181//PF02734//PF13499//PF13833 EF hand//Tetratricopeptide repeat//Dak1 domain//PCI domain//EF hand//Tetratricopeptide repeat//DAK2 domain//EF-hand domain pair//EF-hand domain pair GO:0046486//GO:0006071 glycerolipid metabolic process//glycerol metabolic process GO:0005515//GO:0004371//GO:0005509 protein binding//glycerone kinase activity//calcium ion binding -- -- KOG2426 Dihydroxyacetone kinase/glycerone kinase Cluster-8309.35689 BF_2 7521.02 1380.17 515 91083227 XP_973632.1 665 2.6e-67 PREDICTED: 40S ribosomal protein S18 [Tribolium castaneum]>gi|270007711|gb|EFA04159.1| hypothetical protein TcasGA2_TC014405 [Tribolium castaneum] 264667372 GU120422.1 217 5.17437e-108 Chrysomela tremulae ribosomal protein S18 (RpS18) mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q962R1 644 2.9e-66 40S ribosomal protein S18 OS=Spodoptera frugiperda GN=RpS18 PE=2 SV=1 PF00416 Ribosomal protein S13/S18 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003723 structural constituent of ribosome//RNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG3311 Ribosomal protein S18 Cluster-8309.35690 BF_2 1577.16 29.42 2530 642928339 XP_008195541.1 1614 1.2e-176 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog-like isoform X1 [Tribolium castaneum] 571531697 XM_006570187.1 76 6.45824e-29 PREDICTED: Apis mellifera synaptic vesicle membrane protein VAT-1 homolog-like (LOC409207), mRNA -- -- -- -- Q9HCJ6 992 6.3e-106 Synaptic vesicle membrane protein VAT-1 homolog-like OS=Homo sapiens GN=VAT1L PE=1 SV=2 PF08240//PF00107//PF00335//PF02862//PF10152//PF01118 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase//Tetraspanin family//DDHD domain//Predicted coiled-coil domain-containing protein (DUF2360)//Semialdehyde dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0046872//GO:0016620//GO:0051287 metal ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding GO:0016021//GO:0071203 integral component of membrane//WASH complex KOG1197 Predicted quinone oxidoreductase Cluster-8309.35691 BF_2 168.93 3.34 2402 642919825 XP_008192085.1 496 4.8e-47 PREDICTED: uncharacterized protein LOC103312661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35692 BF_2 30.26 0.60 2393 91085301 XP_968534.1 1697 2.6e-186 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum]>gi|270009220|gb|EFA05668.1| hypothetical protein TcasGA2_TC014946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 521 2.5e-51 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.35694 BF_2 415.00 14.24 1506 189238336 XP_001806936.1 250 1.0e-18 PREDICTED: uncharacterized protein LOC100141997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35695 BF_2 4033.00 244.21 978 288869508 NP_001165861.1 584 1.2e-57 ribosomal protein S6 [Tribolium castaneum]>gi|270014845|gb|EFA11293.1| hypothetical protein TcasGA2_TC010830 [Tribolium castaneum] -- -- -- -- -- K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q95V32 503 1.2e-49 40S ribosomal protein S6 OS=Spodoptera frugiperda GN=RpS6 PE=2 SV=1 PF01092 Ribosomal protein S6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1646 40S ribosomal protein S6 Cluster-8309.35697 BF_2 54.65 3.83 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35698 BF_2 808.42 7.43 4838 270014789 EFA11237.1 2314 1.5e-257 hypothetical protein TcasGA2_TC010769 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHH9 1291 2.6e-140 Tetratricopeptide repeat protein 39B OS=Xenopus laevis GN=ttc39b PE=2 SV=1 PF13414//PF13174//PF06703//PF09110//PF04226//PF13181//PF00515 TPR repeat//Tetratricopeptide repeat//Microsomal signal peptidase 25 kDa subunit (SPC25)//HAND//Transglycosylase associated protein//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0043044//GO:0006465 ATP-dependent chromatin remodeling//signal peptide processing GO:0031491//GO:0005515//GO:0008233 nucleosome binding//protein binding//peptidase activity GO:0000785//GO:0016021//GO:0005787 chromatin//integral component of membrane//signal peptidase complex KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1 Cluster-8309.35700 BF_2 3933.00 600.67 561 765141696 XP_011482082.1 704 8.4e-72 PREDICTED: polyubiquitin-C [Oryzias latipes] 330805886 XM_003290860.1 206 7.38565e-102 Dictyostelium purpureum ubiquitin, mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 P0CG67 699 1.3e-72 Polyubiquitin-B OS=Gorilla gorilla gorilla GN=UBB PE=3 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35701 BF_2 207.59 4.66 2152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35704 BF_2 320.96 2.91 4902 478255990 ENN76189.1 1139 2.7e-121 hypothetical protein YQE_07157, partial [Dendroctonus ponderosae] 755992161 XM_011314822.1 134 7.21202e-61 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 710 6.1e-73 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00549//PF00583//PF13508//PF08445//PF13673 CoA-ligase//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0016747//GO:0008080 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.35705 BF_2 1934.07 40.82 2269 91086399 XP_974859.1 2065 5.2e-229 PREDICTED: 26S protease regulatory subunit 4 [Tribolium castaneum]>gi|270010293|gb|EFA06741.1| hypothetical protein TcasGA2_TC009675 [Tribolium castaneum] 829812394 XM_012773957.1 384 0 PREDICTED: Microcebus murinus proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1), mRNA K03062 PSMC1, RPT2 26S proteasome regulatory subunit T2 http://www.genome.jp/dbget-bin/www_bget?ko:K03062 P48601 1995 2.8e-222 26S protease regulatory subunit 4 OS=Drosophila melanogaster GN=Rpt2 PE=1 SV=2 PF00931//PF00910//PF02367//PF02562//PF07726//PF00005//PF07724//PF00004//PF00158//PF06068//PF01057//PF05496//PF07728//PF01695 NB-ARC domain//RNA helicase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//ABC transporter//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006355//GO:0006281//GO:0019079//GO:0030163//GO:0006310//GO:0002949 regulation of transcription, DNA-templated//DNA repair//viral genome replication//protein catabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0016887//GO:0008134//GO:0005524//GO:0003724//GO:0009378//GO:0017111//GO:0043531//GO:0003723//GO:0003678 ATPase activity//transcription factor binding//ATP binding//RNA helicase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//ADP binding//RNA binding//DNA helicase activity GO:0005737//GO:0009379//GO:0005667//GO:0005657 cytoplasm//Holliday junction helicase complex//transcription factor complex//replication fork KOG0726 26S proteasome regulatory complex, ATPase RPT2 Cluster-8309.35706 BF_2 20.01 1.03 1103 -- -- -- -- -- 642913456 XM_008202798.1 98 1.63089e-41 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 17 (LOC663344), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35707 BF_2 1103.69 18.06 2844 546677850 ERL88607.1 2041 4.0e-226 hypothetical protein D910_05992 [Dendroctonus ponderosae] -- -- -- -- -- K04727 PDCD8, AIF programmed cell death 8 (apoptosis-inducing factor) http://www.genome.jp/dbget-bin/www_bget?ko:K04727 Q9JM53 1454 1.9e-159 Apoptosis-inducing factor 1, mitochondrial OS=Rattus norvegicus GN=Aifm1 PE=1 SV=1 PF01593//PF14721//PF00070//PF07992//PF01266//PF11590 Flavin containing amine oxidoreductase//Apoptosis-inducing factor, mitochondrion-associated, C-term//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//DNA polymerase catalytic subunit Pol GO:0006260//GO:0055114//GO:0051252 DNA replication//oxidation-reduction process//regulation of RNA metabolic process GO:0046983//GO:0016491//GO:0003887//GO:0004523 protein dimerization activity//oxidoreductase activity//DNA-directed DNA polymerase activity//RNA-DNA hybrid ribonuclease activity GO:0042575 DNA polymerase complex KOG1346 Programmed cell death 8 (apoptosis-inducing factor) Cluster-8309.35708 BF_2 40.48 0.41 4397 642934860 XP_971174.2 3111 0.0e+00 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] 198472181 XM_001355830.2 178 2.24391e-85 Drosophila pseudoobscura pseudoobscura GA11069 (Dpse\GA11069), partial mRNA K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 2572 6.8e-289 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00258//PF00667//PF00175 Flavodoxin//FAD binding domain//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.35711 BF_2 14.26 0.42 1696 642936715 XP_008198550.1 1103 1.4e-117 PREDICTED: 60S ribosomal protein L5 [Tribolium castaneum]>gi|270000965|gb|EEZ97412.1| hypothetical protein TcasGA2_TC011241 [Tribolium castaneum] 665810153 XM_008555260.1 159 3.11866e-75 PREDICTED: Microplitis demolitor 60S ribosomal protein L5 (LOC103575464), mRNA K02932 RP-L5e, RPL5 large subunit ribosomal protein L5e http://www.genome.jp/dbget-bin/www_bget?ko:K02932 O76190 989 9.4e-106 60S ribosomal protein L5 OS=Bombyx mori GN=RpL5 PE=2 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG0875 60S ribosomal protein L5 Cluster-8309.35712 BF_2 3527.66 56.33 2907 189238197 XP_001807880.1 3338 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|642925484|ref|XP_008194570.1| PREDICTED: eukaryotic translation initiation factor 3 subunit C [Tribolium castaneum]>gi|270008848|gb|EFA05296.1| hypothetical protein TcasGA2_TC015453 [Tribolium castaneum] 755988497 XM_011313566.1 299 8.05237e-153 PREDICTED: Fopius arisanus eukaryotic translation initiation factor 3 subunit C (LOC105271805), mRNA K03252 EIF3C translation initiation factor 3 subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K03252 Q17Q06 2672 1.1e-300 Eukaryotic translation initiation factor 3 subunit C OS=Aedes aegypti GN=eIF3-S8 PE=3 SV=1 PF01399//PF05470 PCI domain//Eukaryotic translation initiation factor 3 subunit 8 N-terminus GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0031369//GO:0005515 translation initiation factor activity//translation initiation factor binding//protein binding GO:0005840//GO:0005852 ribosome//eukaryotic translation initiation factor 3 complex KOG1076 Translation initiation factor 3, subunit c (eIF-3c) Cluster-8309.35713 BF_2 91.52 1.34 3140 270010184 EFA06632.1 2456 3.3e-274 hypothetical protein TcasGA2_TC009552 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08622 Svf1-like GO:0006979 response to oxidative stress -- -- -- -- -- -- Cluster-8309.35715 BF_2 39.00 2.13 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35716 BF_2 154.00 12.79 791 270006594 EFA03042.1 295 3.2e-24 hypothetical protein TcasGA2_TC010468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35718 BF_2 10367.18 46.16 9682 270010611 EFA07059.1 1520 3.5e-165 hypothetical protein TcasGA2_TC010036 [Tribolium castaneum] 189239538 XM_970519.2 321 1.5934e-164 PREDICTED: Tribolium castaneum ras-related protein Rab-23 (LOC664521), mRNA K06234 RAB23 Ras-related protein Rab-23 http://www.genome.jp/dbget-bin/www_bget?ko:K06234 Q9ULC3 565 7.9e-56 Ras-related protein Rab-23 OS=Homo sapiens GN=RAB23 PE=1 SV=1 PF04670//PF10662//PF00071//PF03193//PF00025//PF02421//PF01926//PF12106//PF08477//PF00735 Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ferrous iron transport protein B//50S ribosome-binding GTPase//Colicin C terminal ribonuclease domain//Ras of Complex, Roc, domain of DAPkinase//Septin GO:0006576//GO:0007264//GO:0015684//GO:0051252 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport//regulation of RNA metabolic process GO:0015093//GO:0005524//GO:0003924//GO:0004540//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//ribonuclease activity//GTP binding GO:0016021 integral component of membrane KOG0079 GTP-binding protein H-ray, small G protein superfamily Cluster-8309.35719 BF_2 12.04 0.44 1420 478257611 ENN77763.1 268 7.7e-21 hypothetical protein YQE_05735, partial [Dendroctonus ponderosae]>gi|546673585|gb|ERL85154.1| hypothetical protein D910_02576, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35725 BF_2 1498.62 17.89 3791 642918236 XP_008191424.1 3015 0.0e+00 PREDICTED: uncharacterized protein LOC658718 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.25693e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00130//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.35726 BF_2 2878.03 76.64 1858 332372941 AEE61612.1 1837 1.2e-202 unknown [Dendroctonus ponderosae] 642917730 XM_008193127.1 339 2.97123e-175 PREDICTED: Tribolium castaneum glutamine synthetase 2 cytoplasmic (LOC656087), transcript variant X4, mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 P20478 1509 5.2e-166 Glutamine synthetase 2 cytoplasmic OS=Drosophila melanogaster GN=Gs2 PE=2 SV=3 PF03951//PF01844//PF00120 Glutamine synthetase, beta-Grasp domain//HNH endonuclease//Glutamine synthetase, catalytic domain GO:0009252//GO:0006807//GO:0006542 peptidoglycan biosynthetic process//nitrogen compound metabolic process//glutamine biosynthetic process GO:0003676//GO:0004356//GO:0004519 nucleic acid binding//glutamate-ammonia ligase activity//endonuclease activity -- -- KOG0683 Glutamine synthetase Cluster-8309.35727 BF_2 85.10 1.56 2568 546682338 ERL92286.1 1172 2.1e-125 hypothetical protein D910_09603 [Dendroctonus ponderosae] -- -- -- -- -- K15728 LPIN phosphatidate phosphatase LPIN http://www.genome.jp/dbget-bin/www_bget?ko:K15728 Q7TNN8 385 1.6e-35 Phosphatidate phosphatase LPIN3 OS=Mus spretus GN=Lpin3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2116 Protein involved in plasmid maintenance/nuclear protein involved in lipid metabolism Cluster-8309.35728 BF_2 9036.86 112.18 3657 642930669 XP_008199217.1 692 1.4e-69 PREDICTED: uncharacterized protein LOC657834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53814 363 7.9e-33 Smoothelin OS=Homo sapiens GN=SMTN PE=1 SV=7 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.35729 BF_2 7755.80 17.97 18338 91087317 XP_975584.1 22328 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X1 [Tribolium castaneum]>gi|270010987|gb|EFA07435.1| dynein heavy chain [Tribolium castaneum] 642929800 XM_970491.2 4295 0 PREDICTED: Tribolium castaneum dynein heavy chain (LOC664489), transcript variant X1, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 19870 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF02932//PF03767//PF00437//PF00004//PF03028//PF12106//PF01695//PF07728//PF02477//PF01580//PF00910//PF00005 Neurotransmitter-gated ion-channel transmembrane region//HAD superfamily, subfamily IIIB (Acid phosphatase)//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor//Colicin C terminal ribonuclease domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Nucleocapsid N protein//FtsK/SpoIIIE family//RNA helicase//ABC transporter GO:0006811//GO:0006771//GO:0051252//GO:0007017//GO:0006810//GO:0006200//GO:0019497//GO:0007018 ion transport//riboflavin metabolic process//regulation of RNA metabolic process//microtubule-based process//transport//obsolete ATP catabolic process//hexachlorocyclohexane metabolic process//microtubule-based movement GO:0003724//GO:0003777//GO:0003723//GO:0003677//GO:0000166//GO:0003993//GO:0016887//GO:0004540//GO:0005524 RNA helicase activity//microtubule motor activity//RNA binding//DNA binding//nucleotide binding//acid phosphatase activity//ATPase activity//ribonuclease activity//ATP binding GO:0016020//GO:0005874//GO:0030286//GO:0019013 membrane//microtubule//dynein complex//viral nucleocapsid KOG3595 Dyneins, heavy chain Cluster-8309.35730 BF_2 67.99 0.41 7225 390198530 AFL70632.1 2550 9.6e-285 putative hypoxia-inducible factor 1 beta [Callosobruchus maculatus] 820805517 KP147913.1 433 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1719 9.0e-190 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF00989//PF05191//PF00010//PF08447 PAS fold//Adenylate kinase, active site lid//Helix-loop-helix DNA-binding domain//PAS fold GO:0006144//GO:0046034//GO:0006355 purine nucleobase metabolic process//ATP metabolic process//regulation of transcription, DNA-templated GO:0046983//GO:0004017//GO:0005515 protein dimerization activity//adenylate kinase activity//protein binding -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.35731 BF_2 70.00 7.47 679 570341948 AHE77372.1 515 8.4e-50 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 231 3.0e-18 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF01873 Domain found in IF2B/IF5 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.35732 BF_2 261.00 43.00 541 91087837 XP_967757.1 262 1.5e-20 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02163//PF03015 Peptidase family M50//Male sterility protein GO:0006508 proteolysis GO:0080019//GO:0004222 fatty-acyl-CoA reductase (alcohol-forming) activity//metalloendopeptidase activity -- -- -- -- Cluster-8309.35733 BF_2 31.57 0.62 2433 642928778 XP_008195558.1 1770 9.0e-195 PREDICTED: hexosaminidase 1 isoform X2 [Tribolium castaneum] 755880535 XM_005185434.2 54 1.05348e-16 PREDICTED: Musca domestica chitooligosaccharidolytic beta-N-acetylglucosaminidase (LOC101894273), mRNA K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49010 1441 5.2e-158 Chitooligosaccharidolytic beta-N-acetylglucosaminidase OS=Bombyx mori PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.35734 BF_2 385.00 128.08 412 91083339 XP_974988.1 344 3.4e-30 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 [Tribolium castaneum]>gi|270008152|gb|EFA04600.1| hypothetical protein TcasGA2_TC013353 [Tribolium castaneum] -- -- -- -- -- K03946 NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03946 P0CB79 306 3.6e-27 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 OS=Pongo abelii GN=NDUFA2 PE=3 SV=1 PF02605 Photosystem I reaction centre subunit XI GO:0015979 photosynthesis -- -- GO:0009522//GO:0009538 photosystem I//photosystem I reaction center KOG3446 NADH:ubiquinone oxidoreductase NDUFA2/B8 subunit Cluster-8309.35735 BF_2 1214.79 4.18 12439 642937614 XP_008199122.1 15392 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 816 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 O95714 5622 0.0e+00 E3 ubiquitin-protein ligase HERC2 OS=Homo sapiens GN=HERC2 PE=1 SV=2 PF02898//PF07236//PF00569//PF06701 Nitric oxide synthase, oxygenase domain//Phytoreovirus S7 protein//Zinc finger, ZZ type//Mib_herc2 GO:0006809//GO:0016567//GO:0055114 nitric oxide biosynthetic process//protein ubiquitination//oxidation-reduction process GO:0004842//GO:0004517//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//nitric-oxide synthase activity//metal ion binding//zinc ion binding GO:0019012 virion KOG1426 FOG: RCC1 domain Cluster-8309.35736 BF_2 2336.95 324.91 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097//PF08119 Arthropod defensin//Scorpion acidic alpha-KTx toxin family GO:0006810//GO:0006952//GO:0009405 transport//defense response//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.35737 BF_2 536.00 8.87 2816 642937614 XP_008199122.1 3236 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase HERC2 [Tribolium castaneum] 642937613 XM_008200900.1 600 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 Q9VR91 2613 7.6e-294 Probable E3 ubiquitin-protein ligase HERC2 OS=Drosophila melanogaster GN=HERC2 PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.35738 BF_2 22.89 0.41 2601 478253032 ENN73412.1 234 1.2e-16 hypothetical protein YQE_09974, partial [Dendroctonus ponderosae] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q965X6 208 5.3e-15 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis elegans GN=siah-1 PE=1 SV=3 PF03145//PF14634//PF00097//PF02176//PF00942//PF15965//PF05195 Seven in absentia protein family//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//Cellulose binding domain//TRAF-like zinc-finger//Aminopeptidase P, N-terminal domain GO:0007275//GO:0006511//GO:0005975 multicellular organismal development//ubiquitin-dependent protein catabolic process//carbohydrate metabolic process GO:0030248//GO:0030145//GO:0005515//GO:0008270//GO:0004177//GO:0046872 cellulose binding//manganese ion binding//protein binding//zinc ion binding//aminopeptidase activity//metal ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.35739 BF_2 9.92 0.79 812 264667343 ACY71257.1 443 2.3e-41 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 315 6.4e-28 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF03868 Ribosomal protein L6, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1694 60s ribosomal protein L6 Cluster-8309.3574 BF_2 51.71 0.41 5517 565660789 CDK37791.1 3344 0.0e+00 metabotropic GABA-B receptor subtype 1 [Periplaneta americana] 13160941 AF318272.1 279 2.01692e-141 AF318272 Drosophila melanogaster metabotropic GABA-B receptor subtype 1 (GABA-B-R1) mRNA, complete cds K04615 GABBR gamma-aminobutyric acid type B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04615 Q9UBS5 2015 3.3e-224 Gamma-aminobutyric acid type B receptor subunit 1 OS=Homo sapiens GN=GABBR1 PE=1 SV=1 PF00003//PF01769 7 transmembrane sweet-taste receptor of 3 GCPR//Divalent cation transporter GO:0006812//GO:0007186 cation transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0008324 G-protein coupled receptor activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1055 GABA-B ion channel receptor subunit GABABR1 and related subunits, G-protein coupled receptor superfamily Cluster-8309.35740 BF_2 114.96 1.47 3556 91091500 XP_968802.1 752 1.5e-76 PREDICTED: GTP-binding protein SAR1b [Tribolium castaneum]>gi|270001011|gb|EEZ97458.1| hypothetical protein TcasGA2_TC011289 [Tribolium castaneum] 676480291 XM_009063766.1 50 2.58685e-14 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q5HZY2 571 5.8e-57 GTP-binding protein SAR1b OS=Rattus norvegicus GN=Sar1b PE=2 SV=1 PF00071//PF04670//PF05493//PF00503//PF06858//PF00025//PF01926//PF08477 Ras family//Gtr1/RagA G protein conserved region//ATP synthase subunit H//G-protein alpha subunit//Nucleolar GTP-binding protein 1 (NOG1)//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0015991//GO:0007186//GO:0015992//GO:0007165//GO:0006886//GO:0016192 small GTPase mediated signal transduction//ATP hydrolysis coupled proton transport//G-protein coupled receptor signaling pathway//proton transport//signal transduction//intracellular protein transport//vesicle-mediated transport GO:0004871//GO:0005525//GO:0015078//GO:0019001//GO:0031683//GO:0003924 signal transducer activity//GTP binding//hydrogen ion transmembrane transporter activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0033179//GO:0005783//GO:0005794 proton-transporting V-type ATPase, V0 domain//endoplasmic reticulum//Golgi apparatus KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.35743 BF_2 729.00 94.45 610 559163445 AHB11276.1 389 3.1e-35 attacin-like immune protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03769 Attacin, C-terminal region -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.35745 BF_2 36.49 2.81 830 91083431 XP_969550.1 269 3.5e-21 PREDICTED: membrane magnesium transporter 1 [Tribolium castaneum]>gi|270007793|gb|EFA04241.1| hypothetical protein TcasGA2_TC014495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LC4 171 3.3e-11 Membrane magnesium transporter 1 OS=Bos taurus GN=MMGT1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35748 BF_2 345.82 11.43 1553 642918856 XP_008191616.1 670 2.1e-67 PREDICTED: pericentriolar material 1 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K16537 PCM1 pericentriolar material 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K16537 Q9PVV4 186 1.1e-12 Pericentriolar material 1 protein OS=Xenopus laevis GN=pcm1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35750 BF_2 55.95 0.40 6207 546675274 ERL86510.1 2651 1.6e-296 hypothetical protein D910_03914 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PAR5 714 2.7e-73 GTPase-activating protein and VPS9 domain-containing protein 1 OS=Mus musculus GN=Gapvd1 PE=1 SV=2 PF02881//PF00616 SRP54-type protein, helical bundle domain//GTPase-activator protein for Ras-like GTPase GO:0043087//GO:0006614 regulation of GTPase activity//SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.35751 BF_2 34.62 0.61 2668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03896 Translocon-associated protein (TRAP), alpha subunit -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.35754 BF_2 17.04 0.50 1704 752884397 XP_011259939.1 836 1.3e-86 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Camponotus floridanus]>gi|307176419|gb|EFN65993.1| Fatty acyl-CoA reductase 1 [Camponotus floridanus] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 588 3.0e-59 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01118//PF01073//PF01370//PF03015//PF08831 Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Male sterility protein//Class II MHC-associated invariant chain trimerisation domain GO:0006886//GO:0007165//GO:0008209//GO:0006694//GO:0055114//GO:0006955//GO:0008207//GO:0008210//GO:0019882 intracellular protein transport//signal transduction//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//immune response//C21-steroid hormone metabolic process//estrogen metabolic process//antigen processing and presentation GO:0016616//GO:0042289//GO:0050662//GO:0003854//GO:0016620//GO:0080019//GO:0051287//GO:0003824 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//MHC class II protein binding//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//NAD binding//catalytic activity GO:0042613//GO:0016020 MHC class II protein complex//membrane -- -- Cluster-8309.35755 BF_2 927.17 126.80 593 91080463 XP_970045.1 406 3.2e-37 PREDICTED: NADH dehydrogenase [ubiquinone] 1 subunit C2 [Tribolium castaneum]>gi|270006395|gb|EFA02843.1| NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2 [Tribolium castaneum] -- -- -- -- -- K03968 NDUFC2 NADH dehydrogenase (ubiquinone) 1 subunit C2 http://www.genome.jp/dbget-bin/www_bget?ko:K03968 -- -- -- -- PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0006814//GO:0022900//GO:0006744//GO:0015992//GO:0006120 sodium ion transport//electron transport chain//ubiquinone biosynthetic process//proton transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016020//GO:0005739//GO:0005743 membrane//mitochondrion//mitochondrial inner membrane -- -- Cluster-8309.35756 BF_2 3912.49 76.92 2415 91093505 XP_969151.1 2479 5.5e-277 PREDICTED: NADP-dependent malic enzyme [Tribolium castaneum]>gi|270002678|gb|EEZ99125.1| hypothetical protein TcasGA2_TC005232 [Tribolium castaneum] 194765020 XM_001964590.1 291 1.86973e-148 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1667 3.2e-184 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0055114//GO:0006108//GO:0015976//GO:0006099//GO:0006090 oxidation-reduction process//malate metabolic process//carbon utilization//tricarboxylic acid cycle//pyruvate metabolic process GO:0051287//GO:0046872//GO:0004471 NAD binding//metal ion binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.35757 BF_2 258.65 1.92 5909 642919356 XP_008191837.1 2644 9.9e-296 PREDICTED: kinesin-like protein costa isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16844 1130 1.5e-121 Kinesin-like protein costa OS=Drosophila melanogaster GN=cos PE=1 SV=2 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.35759 BF_2 175.73 1.40 5539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35760 BF_2 92.37 1.42 3009 332374224 AEE62253.1 1544 1.8e-168 unknown [Dendroctonus ponderosae] 662188737 XM_008489835.1 98 4.53283e-41 PREDICTED: Diaphorina citri elongation factor Tu, mitochondrial (LOC103524802), mRNA K02358 tuf, TUFM elongation factor Tu http://www.genome.jp/dbget-bin/www_bget?ko:K02358 P49411 1108 2.7e-119 Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 PF00231//PF02602//PF00894//PF05165//PF03144//PF01926 ATP synthase//Uroporphyrinogen-III synthase HemD//Luteovirus coat protein//GTP cyclohydrolase III//Elongation factor Tu domain 2//50S ribosome-binding GTPase GO:0015992//GO:0009058//GO:0006807//GO:0006783//GO:0015986//GO:0033014//GO:0006119//GO:0015994 proton transport//biosynthetic process//nitrogen compound metabolic process//heme biosynthetic process//ATP synthesis coupled proton transport//tetrapyrrole biosynthetic process//oxidative phosphorylation//chlorophyll metabolic process GO:0046933//GO:0004852//GO:0046961//GO:0005198//GO:0003933//GO:0005525 proton-transporting ATP synthase activity, rotational mechanism//uroporphyrinogen-III synthase activity//proton-transporting ATPase activity, rotational mechanism//structural molecule activity//GTP cyclohydrolase activity//GTP binding GO:0045259//GO:0019028//GO:0045261 proton-transporting ATP synthase complex//viral capsid//proton-transporting ATP synthase complex, catalytic core F(1) KOG0460 Mitochondrial translation elongation factor Tu Cluster-8309.35762 BF_2 3579.04 21.82 7148 546683575 ERL93373.1 567 8.3e-55 hypothetical protein D910_10665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35764 BF_2 17.78 0.51 1739 264667395 ACY71283.1 883 4.6e-92 ribosomal protein S4 [Chrysomela tremula] 264667394 GU120433.1 137 5.43e-63 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 839 2.4e-88 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.35765 BF_2 91.36 1.15 3597 -- -- -- -- -- 642921886 XM_970820.3 81 1.53107e-31 PREDICTED: Tribolium castaneum Y-box factor homolog (LOC656063), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.35767 BF_2 1086.12 35.84 1555 642912944 XP_008201318.1 854 9.5e-89 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 539 1.3e-53 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35768 BF_2 18.00 6.23 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83652 133 4.1e-07 Antimicrobial peptide Alo-2 OS=Acrocinus longimanus PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35769 BF_2 53.52 0.63 3834 546674788 ERL86084.1 2900 0.0e+00 hypothetical protein D910_03498, partial [Dendroctonus ponderosae] 573905099 XM_006640208.1 158 2.56397e-74 PREDICTED: Lepisosteus oculatus ubiquitin-protein ligase E3B-like (LOC102687052), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q7Z3V4 2102 1.9e-234 Ubiquitin-protein ligase E3B OS=Homo sapiens GN=UBE3B PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0942 E3 ubiquitin protein ligase Cluster-8309.35770 BF_2 141.86 1.56 4092 642935654 XP_008198101.1 3404 0.0e+00 PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935656|ref|XP_008198102.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum]>gi|642935658|ref|XP_008198103.1| PREDICTED: receptor-type tyrosine-protein phosphatase N2 [Tribolium castaneum] 817215019 XM_012428261.1 140 2.77716e-64 PREDICTED: Orussus abietinus uncharacterized LOC105701487 (LOC105701487), mRNA K07817 PTPRN receptor-type tyrosine-protein phosphatase N http://www.genome.jp/dbget-bin/www_bget?ko:K07817 O02695 1329 8.6e-145 Receptor-type tyrosine-protein phosphatase N2 OS=Macaca nemestrina GN=PTPRN2 PE=2 SV=1 PF10590//PF00102//PF00782 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0055114//GO:0006570//GO:0006470 oxidation-reduction process//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0016638//GO:0008138 protein tyrosine phosphatase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//protein tyrosine/serine/threonine phosphatase activity -- -- KOG0793 Protein tyrosine phosphatase Cluster-8309.35771 BF_2 1414.17 26.11 2553 478254028 ENN74320.1 1365 8.7e-148 hypothetical protein YQE_09291, partial [Dendroctonus ponderosae] -- -- -- -- -- K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 Q9D2A5 304 3.8e-26 Cyclic AMP-responsive element-binding protein 3-like protein 4 OS=Mus musculus GN=Creb3l4 PE=1 SV=1 PF04281//PF03131//PF07716//PF00170 Mitochondrial import receptor subunit Tom22//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006886//GO:0006355 intracellular protein transport//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005741 transcription factor complex//nucleus//mitochondrial outer membrane KOG0709 CREB/ATF family transcription factor Cluster-8309.35777 BF_2 235.09 6.19 1877 861575110 KMQ81911.1 612 1.3e-60 alpha-l1 nicotinic acetyl choline receptor [Lasius niger] 162072655 EU164661.1 928 0 Akalyptoischion atrichos isolate CO474 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35778 BF_2 156.00 6.35 1315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35779 BF_2 33.08 0.84 1939 270006792 EFA03240.1 481 2.1e-45 hypothetical protein TcasGA2_TC013172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 308 1.0e-26 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.3578 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35780 BF_2 3162.50 60.11 2488 332375863 AEE63072.1 1058 3.4e-112 unknown [Dendroctonus ponderosae]>gi|478250905|gb|ENN71391.1| hypothetical protein YQE_11938, partial [Dendroctonus ponderosae]>gi|546671259|gb|ERL83646.1| hypothetical protein D910_00798 [Dendroctonus ponderosae]>gi|546678254|gb|ERL88926.1| hypothetical protein D910_06304 [Dendroctonus ponderosae] 755932870 XM_011316165.1 162 9.89931e-77 PREDICTED: Fopius arisanus ras-like GTP-binding protein Rho1 (LOC105273622), transcript variant X9, mRNA K04513 RHOA Ras homolog gene family, member A http://www.genome.jp/dbget-bin/www_bget?ko:K04513 P48148 946 1.3e-100 Ras-like GTP-binding protein Rho1 OS=Drosophila melanogaster GN=Rho1 PE=1 SV=1 PF08477//PF07244//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Surface antigen variable number repeat//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0019867 outer membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.35781 BF_2 8102.00 115.01 3234 761896179 AJP75147.1 3356 0.0e+00 pyrroline-5-carboxylate synthetase [Leptinotarsa decemlineata] 642912198 XM_008202627.1 493 0 PREDICTED: Tribolium castaneum delta-1-pyrroline-5-carboxylate synthase (LOC658917), mRNA K12657 ALDH18A1, P5CS delta-1-pyrroline-5-carboxylate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K12657 Q9Z110 2171 1.6e-242 Delta-1-pyrroline-5-carboxylate synthase OS=Mus musculus GN=Aldh18a1 PE=1 SV=2 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG4165 Gamma-glutamyl phosphate reductase Cluster-8309.35782 BF_2 809.32 8.79 4138 752869486 XP_011251858.1 1705 5.3e-187 PREDICTED: WD repeat-containing protein 47 isoform X2 [Camponotus floridanus] 766926462 XM_011496875.1 240 7.22446e-120 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- Q8CGF6 1098 5.3e-118 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.35783 BF_2 251.09 2.22 5015 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF00983//PF01926 Elongation factor G, domain IV//Elongation factor Tu domain 2//Tymovirus coat protein//50S ribosome-binding GTPase -- -- GO:0005198//GO:0005525 structural molecule activity//GTP binding GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.35784 BF_2 18.67 0.86 1199 91088963 XP_974027.1 485 4.5e-46 PREDICTED: cytochrome c oxidase subunit 6A2, mitochondrial [Tribolium castaneum]>gi|270012806|gb|EFA09254.1| hypothetical protein TcasGA2_TC006519 [Tribolium castaneum] 734646853 XM_010754281.1 52 6.6149e-16 PREDICTED: Larimichthys crocea cytochrome c oxidase subunit 6A, mitochondrial-like (LOC104937958), mRNA K02266 COX6A cytochrome c oxidase subunit 6a http://www.genome.jp/dbget-bin/www_bget?ko:K02266 P12074 286 2.2e-24 Cytochrome c oxidase subunit 6A1, mitochondrial OS=Homo sapiens GN=COX6A1 PE=1 SV=4 PF02046 Cytochrome c oxidase subunit VIa GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005751//GO:0005743//GO:0045277 mitochondrial respiratory chain complex IV//mitochondrial inner membrane//respiratory chain complex IV KOG3469 Cytochrome c oxidase, subunit VIa/COX13 Cluster-8309.35785 BF_2 2725.02 584.46 482 91093173 XP_967937.1 413 4.0e-38 PREDICTED: 40S ribosomal protein S21 [Tribolium castaneum]>gi|270012942|gb|EFA09390.1| hypothetical protein TcasGA2_TC004308 [Tribolium castaneum] 645004566 XM_001604620.3 87 8.92681e-36 PREDICTED: Nasonia vitripennis 40S ribosomal protein S21 (LOC100114107), mRNA K02971 RP-S21e, RPS21 small subunit ribosomal protein S21e http://www.genome.jp/dbget-bin/www_bget?ko:K02971 Q4GXP2 405 1.4e-38 40S ribosomal protein S21 OS=Biphyllus lunatus GN=RpS21 PE=3 SV=1 PF01249 Ribosomal protein S21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3486 40S ribosomal protein S21 Cluster-8309.35787 BF_2 6214.00 265.57 1266 546674191 ERL85631.1 1076 1.4e-114 hypothetical protein D910_03049 [Dendroctonus ponderosae] 306847626 HM210791.1 72 5.33199e-27 Plutella xylostella Rieske iron-sulfur protein gene, complete cds K00411 UQCRFS1, RIP1, petA ubiquinol-cytochrome c reductase iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00411 Q69BJ9 794 2.9e-83 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Aotus azarae GN=UQCRFS1 PE=3 SV=1 PF02921//PF09165//PF00355 Ubiquinol cytochrome reductase transmembrane region//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//Rieske [2Fe-2S] domain GO:0015992//GO:0006119//GO:0055114//GO:0006118 proton transport//oxidative phosphorylation//oxidation-reduction process//obsolete electron transport GO:0016491//GO:0008121//GO:0051537 oxidoreductase activity//ubiquinol-cytochrome-c reductase activity//2 iron, 2 sulfur cluster binding -- -- KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-8309.35788 BF_2 426.00 6.73 2937 189236489 XP_975064.2 1412 3.5e-153 PREDICTED: putative neutral sphingomyelinase [Tribolium castaneum]>gi|270005347|gb|EFA01795.1| hypothetical protein TcasGA2_TC007396 [Tribolium castaneum] -- -- -- -- -- K12351 SMPD2 sphingomyelin phosphodiesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12351 Q9VZS6 737 2.7e-76 Putative neutral sphingomyelinase OS=Drosophila melanogaster GN=CG12034 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3873 Sphingomyelinase family protein Cluster-8309.35789 BF_2 359.20 5.25 3151 642936524 XP_008198472.1 3435 0.0e+00 PREDICTED: transmembrane GTPase Marf [Tribolium castaneum]>gi|642936526|ref|XP_970147.2| PREDICTED: transmembrane GTPase Marf [Tribolium castaneum] 462318797 APGK01044284.1 207 1.21302e-101 Dendroctonus ponderosae Seq01044294, whole genome shotgun sequence K06030 MFN mitofusin http://www.genome.jp/dbget-bin/www_bget?ko:K06030 Q7YU24 2272 3.0e-254 Transmembrane GTPase Marf OS=Drosophila melanogaster GN=Marf PE=1 SV=1 PF11734//PF04799//PF01926 TilS substrate C-terminal domain//fzo-like conserved region//50S ribosome-binding GTPase GO:0008033//GO:0008053 tRNA processing//mitochondrial fusion GO:0016879//GO:0003924//GO:0005524//GO:0005525//GO:0000166 ligase activity, forming carbon-nitrogen bonds//GTPase activity//ATP binding//GTP binding//nucleotide binding GO:0016021//GO:0005737//GO:0005741 integral component of membrane//cytoplasm//mitochondrial outer membrane KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis Cluster-8309.35790 BF_2 101.29 0.96 4706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17053//PF03854 Genetic interactor of prohibitin 5//P-11 zinc finger GO:0000002 mitochondrial genome maintenance GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.35791 BF_2 650.85 23.95 1424 755948956 XP_011300956.1 1243 6.8e-134 PREDICTED: 40S ribosomal protein S4 [Fopius arisanus] 264667394 GU120433.1 359 0 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q56FH2 1208 3.2e-131 40S ribosomal protein S4 OS=Lysiphlebus testaceipes GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.35792 BF_2 357.00 37.07 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35793 BF_2 415.74 8.57 2316 282848147 NP_001164292.1 1039 5.0e-110 kayak isoform A [Tribolium castaneum]>gi|270014251|gb|EFA10699.1| kayak [Tribolium castaneum] -- -- -- -- -- K09031 FOSLN fos-like antigen, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09031 B4K617 198 6.8e-14 Transcription factor kayak OS=Drosophila mojavensis GN=kay PE=3 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.35794 BF_2 4.00 0.59 569 545222987 XP_001504999.2 705 6.6e-72 PREDICTED: 40S ribosomal protein S13 [Equus caballus]>gi|664740863|ref|XP_008527733.1| PREDICTED: 40S ribosomal protein S13 [Equus przewalskii] 15213813 AF400210.1 126 2.22171e-57 Spodoptera frugiperda ribosomal protein S13 mRNA, complete cds K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 P49393 703 4.6e-73 40S ribosomal protein S13 OS=Xenopus laevis GN=rps13 PE=3 SV=2 PF00292//PF00312//PF08069 'Paired box' domain//Ribosomal protein S15//Ribosomal S13/S15 N-terminal domain GO:0006355//GO:0006412//GO:0042254 regulation of transcription, DNA-templated//translation//ribosome biogenesis GO:0003677//GO:0003735 DNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0400 40S ribosomal protein S13 Cluster-8309.35796 BF_2 5450.12 103.36 2493 91086497 XP_971040.1 1299 3.8e-140 PREDICTED: trimeric intracellular cation channel type B [Tribolium castaneum]>gi|642928310|ref|XP_008195528.1| PREDICTED: trimeric intracellular cation channel type B [Tribolium castaneum]>gi|642928313|ref|XP_008195530.1| PREDICTED: trimeric intracellular cation channel type B [Tribolium castaneum]>gi|270009804|gb|EFA06252.1| hypothetical protein TcasGA2_TC009110 [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8IVF4 580 3.7e-58 Dynein heavy chain 10, axonemal OS=Homo sapiens GN=DNAH10 PE=1 SV=4 PF05197//PF03028 TRIC channel//Dynein heavy chain and region D6 of dynein motor GO:0006812//GO:0007017//GO:0015672//GO:0007018 cation transport//microtubule-based process//monovalent inorganic cation transport//microtubule-based movement GO:0003777//GO:0005261 microtubule motor activity//cation channel activity GO:0016020//GO:0005874//GO:0030286 membrane//microtubule//dynein complex KOG3944 Uncharacterized conserved protein Cluster-8309.35799 BF_2 25.92 2.94 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35800 BF_2 6539.52 271.71 1294 264667419 ACY71295.1 992 7.9e-105 ribosomal protein L19 [Chrysomela tremula] 601036659 KJ028107.1 194 8.26477e-95 Diachasmimorpha longicaudata ribosomal protein L19 (rpl19) mRNA, complete cds K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 P36241 869 5.9e-92 60S ribosomal protein L19 OS=Drosophila melanogaster GN=RpL19 PE=1 SV=2 PF01280 Ribosomal protein L19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1696 60s ribosomal protein L19 Cluster-8309.35801 BF_2 277.00 4.44 2896 795011741 XP_011874268.1 607 7.7e-60 PREDICTED: uncharacterized protein LOC105565573 [Vollenhovia emeryi] -- -- -- -- -- K15448 TRM112, TRMT112 multifunctional methyltransferase subunit TRM112 http://www.genome.jp/dbget-bin/www_bget?ko:K15448 Q9DCG9 366 2.8e-33 Multifunctional methyltransferase subunit TRM112-like protein OS=Mus musculus GN=Trmt112 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1088 Uncharacterized conserved protein Cluster-8309.35802 BF_2 16935.92 634.92 1403 642920676 XP_008192517.1 670 1.9e-67 PREDICTED: troponin I isoform X10 [Tribolium castaneum] 332376704 BT128535.1 225 5.25395e-112 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 555 1.7e-55 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF01496//PF00992 V-type ATPase 116kDa subunit family//Troponin GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0005861//GO:0033179 troponin complex//proton-transporting V-type ATPase, V0 domain KOG3977 Troponin I Cluster-8309.35804 BF_2 266.57 1.91 6135 91090153 XP_972190.1 8471 0.0e+00 PREDICTED: CAD protein [Tribolium castaneum]>gi|270013749|gb|EFA10197.1| hypothetical protein TcasGA2_TC012392 [Tribolium castaneum] 218526269 EU860157.1 823 0 Strangalia bicolor carbamoyl-phosphate synthase (CAD) gene, partial cds K11540 CAD carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase http://www.genome.jp/dbget-bin/www_bget?ko:K11540 P05990 7064 0.0e+00 CAD protein OS=Drosophila melanogaster GN=r PE=1 SV=3 PF02655//PF00113//PF01979//PF07478//PF02786//PF07722//PF02729 ATP-grasp domain//Enolase, C-terminal TIM barrel domain//Amidohydrolase family//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//Peptidase C26//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0006096//GO:0006207//GO:0006541//GO:0006571//GO:0006094//GO:0046436//GO:0006531//GO:0070409//GO:0006520//GO:0009252//GO:0006807//GO:0000162//GO:0006543//GO:0006206//GO:0006522//GO:0009094 glycolytic process//'de novo' pyrimidine nucleobase biosynthetic process//glutamine metabolic process//tyrosine biosynthetic process//gluconeogenesis//D-alanine metabolic process//aspartate metabolic process//carbamoyl phosphate biosynthetic process//cellular amino acid metabolic process//peptidoglycan biosynthetic process//nitrogen compound metabolic process//tryptophan biosynthetic process//glutamine catabolic process//pyrimidine nucleobase metabolic process//alanine metabolic process//L-phenylalanine biosynthetic process GO:0004634//GO:0016787//GO:0005524//GO:0016743//GO:0046872//GO:0004070//GO:0000287//GO:0008716//GO:0016812//GO:0016597 phosphopyruvate hydratase activity//hydrolase activity//ATP binding//carboxyl- or carbamoyltransferase activity//metal ion binding//aspartate carbamoyltransferase activity//magnesium ion binding//D-alanine-D-alanine ligase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides//amino acid binding GO:0009347//GO:0000015 aspartate carbamoyltransferase complex//phosphopyruvate hydratase complex KOG0370 Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) Cluster-8309.35805 BF_2 3855.86 111.41 1735 91094027 XP_967626.1 1283 1.9e-138 PREDICTED: translocating chain-associated membrane protein 1 isoform X1 [Tribolium castaneum]>gi|270003137|gb|EEZ99584.1| hypothetical protein TcasGA2_TC001570 [Tribolium castaneum] -- -- -- -- -- K14010 TRAM1 translocating chain-associated membrane protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14010 Q5XI41 620 5.9e-63 Translocating chain-associated membrane protein 1 OS=Rattus norvegicus GN=Tram1 PE=2 SV=3 PF03798 TLC domain -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1608 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.35806 BF_2 10.07 0.49 1149 642915775 XP_008200074.1 475 6.2e-45 PREDICTED: translocating chain-associated membrane protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14010 TRAM1 translocating chain-associated membrane protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14010 Q9GKZ4 311 2.7e-27 Translocating chain-associated membrane protein 1 OS=Bos taurus GN=TRAM1 PE=2 SV=3 PF03798//PF04901 TLC domain//Receptor activity modifying family GO:0015031//GO:0006886//GO:0008277 protein transport//intracellular protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565 protein transporter activity GO:0016021 integral component of membrane KOG1608 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.35807 BF_2 471.45 6.47 3334 270010125 EFA06573.1 1630 2.1e-178 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] 642927258 XM_969189.2 206 4.61909e-101 PREDICTED: Tribolium castaneum uncharacterized LOC663129 (LOC663129), mRNA K17776 MTX metaxin http://www.genome.jp/dbget-bin/www_bget?ko:K17776 Q2L969 275 1.2e-22 Metaxin-2 OS=Sus scrofa GN=MTX2 PE=2 SV=1 PF13903 PMP-22/EMP/MP20/Claudin tight junction -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.35808 BF_2 294.24 5.94 2361 270016968 EFA13414.1 2409 7.0e-269 hypothetical protein TcasGA2_TC010300 [Tribolium castaneum] 701368608 XM_010009070.1 66 2.18084e-23 PREDICTED: Chaetura pelagica tripartite motif containing 37 (TRIM37), mRNA K10608 TRIM37, MUL tripartite motif-containing protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K10608 Q6PCX9 1742 6.4e-193 E3 ubiquitin-protein ligase TRIM37 OS=Mus musculus GN=Trim37 PE=1 SV=1 PF00917//PF00643//PF01442//PF04632 MATH domain//B-box zinc finger//Apolipoprotein A1/A4/E domain//Fusaric acid resistance protein family GO:0042157//GO:0006869//GO:0006810 lipoprotein metabolic process//lipid transport//transport GO:0008270//GO:0008289//GO:0005515 zinc ion binding//lipid binding//protein binding GO:0005576//GO:0005622//GO:0005886 extracellular region//intracellular//plasma membrane -- -- Cluster-8309.35811 BF_2 1576.37 64.85 1304 546674022 ERL85515.1 565 2.6e-55 hypothetical protein D910_02934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15330 182 2.7e-12 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35812 BF_2 37.78 0.76 2377 478258626 ENN78676.1 1968 9.7e-218 hypothetical protein YQE_04848, partial [Dendroctonus ponderosae]>gi|546685782|gb|ERL95231.1| hypothetical protein D910_12498, partial [Dendroctonus ponderosae] 124303520 DQ872653.2 149 1.59277e-69 Carassius auratus HSP60 mRNA, complete cds K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 O02649 1756 1.5e-194 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-8309.35813 BF_2 5316.08 110.65 2297 559783744 AHB18586.1 2342 4.0e-261 heat shock 60 kDa protein [Leptinotarsa decemlineata] 124303520 DQ872653.2 149 1.53837e-69 Carassius auratus HSP60 mRNA, complete cds K04077 groEL, HSPD1 chaperonin GroEL http://www.genome.jp/dbget-bin/www_bget?ko:K04077 O02649 2089 3.6e-233 60 kDa heat shock protein, mitochondrial OS=Drosophila melanogaster GN=Hsp60 PE=1 SV=3 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0356 Mitochondrial chaperonin, Cpn60/Hsp60p Cluster-8309.35814 BF_2 32.67 0.73 2163 642935333 XP_008197972.1 674 9.8e-68 PREDICTED: uncharacterized protein LOC100142013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 412 9.7e-39 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 PF02170 PAZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.35816 BF_2 49.01 0.63 3525 546673060 ERL84737.1 1807 6.7e-199 hypothetical protein D910_02162 [Dendroctonus ponderosae] 642918235 XM_008193202.1 74 1.16789e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00130//PF00168//PF09202 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain//Rio2, N-terminal GO:0035556//GO:0006468//GO:0009069//GO:0016310 intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0005515 ATP binding//protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.35817 BF_2 44.25 1.39 1622 478250474 ENN70969.1 907 7.1e-95 hypothetical protein YQE_12370, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13678 128 6.2e-06 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF09202//PF00130 Rio2, N-terminal//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0009069//GO:0035556//GO:0006468//GO:0016310 serine family amino acid metabolic process//intracellular signal transduction//protein phosphorylation//phosphorylation GO:0004674//GO:0005524 protein serine/threonine kinase activity//ATP binding -- -- -- -- Cluster-8309.35820 BF_2 670.22 3.29 8797 91080499 XP_971142.1 1128 9.1e-120 PREDICTED: 5'-AMP-activated protein kinase subunit beta-1 [Tribolium castaneum]>gi|270005556|gb|EFA02004.1| hypothetical protein TcasGA2_TC007626 [Tribolium castaneum] 332376520 BT128443.1 148 2.14139e-68 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 2.8e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF00098//PF02148//PF02922//PF06495//PF00096//PF00320//PF04739//PF13912//PF06621//PF00076//PF06467//PF07776//PF07503//PF08675//PF03286//PF16622//PF02892//PF05443//PF13465 Zinc knuckle//Zn-finger in ubiquitin-hydrolases and other protein//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//Fruit fly transformer protein//Zinc finger, C2H2 type//GATA zinc finger//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//Single-minded protein C-terminus//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//HypF finger//RNA binding domain//Pox virus Ag35 surface protein//zinc-finger C2H2-type//BED zinc finger//ROS/MUCR transcriptional regulator protein//Zinc-finger double domain GO:0006397//GO:0006402//GO:0005975//GO:0051252//GO:0046660//GO:0006355 mRNA processing//mRNA catabolic process//carbohydrate metabolic process//regulation of RNA metabolic process//female sex differentiation//regulation of transcription, DNA-templated GO:0046872//GO:0003676//GO:0005515//GO:0003677//GO:0003723//GO:0003700//GO:0004535//GO:0008270//GO:0043565//GO:0004553 metal ion binding//nucleic acid binding//protein binding//DNA binding//RNA binding//transcription factor activity, sequence-specific DNA binding//poly(A)-specific ribonuclease activity//zinc ion binding//sequence-specific DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005667//GO:0019031//GO:0005634//GO:0005737 transcription factor complex//viral envelope//nucleus//cytoplasm KOG1721 FOG: Zn-finger Cluster-8309.35821 BF_2 1595.00 110.50 891 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35822 BF_2 113.00 7.74 898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35823 BF_2 754.10 10.39 3322 91091942 XP_975905.1 1039 7.2e-110 PREDICTED: E3 ubiquitin-protein ligase RNF126 isoform X2 [Tribolium castaneum] 170048596 XM_001870670.1 46 4.04095e-12 Culex quinquefasciatus RING finger protein 126-B, mRNA K11982 RNF115_126 E3 ubiquitin-protein ligase RNF115/126 http://www.genome.jp/dbget-bin/www_bget?ko:K11982 Q9D0C1 380 7.7e-35 E3 ubiquitin-protein ligase RNF115 OS=Mus musculus GN=Rnf115 PE=1 SV=1 PF14634//PF12861//PF17123//PF12678//PF00097//PF13639//PF01155 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0016567//GO:0006464 protein ubiquitination//cellular protein modification process GO:0004842//GO:0016151//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//nickel cation binding//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.35824 BF_2 1914.41 46.03 2027 478262423 ENN81094.1 2754 5.9e-309 hypothetical protein YQE_02462, partial [Dendroctonus ponderosae]>gi|546673644|gb|ERL85208.1| hypothetical protein D910_02629 [Dendroctonus ponderosae] 591382847 XM_007065827.1 101 6.52995e-43 PREDICTED: Chelonia mydas cullin-associated and neddylation-dissociated 1 (CAND1), transcript variant X1, mRNA K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 1898 4.4e-211 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1824 TATA-binding protein-interacting protein Cluster-8309.35825 BF_2 83.14 1.76 2260 478263072 ENN81472.1 767 1.7e-78 hypothetical protein YQE_02164, partial [Dendroctonus ponderosae]>gi|546686021|gb|ERL95421.1| hypothetical protein D910_12685 [Dendroctonus ponderosae] -- -- -- -- -- K00469 MIOX inositol oxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00469 Q4V8T0 458 4.7e-44 Inositol oxygenase OS=Danio rerio GN=miox PE=2 SV=1 PF01075//PF05153//PF00646//PF16622 Glycosyltransferase family 9 (heptosyltransferase)//Myo-inositol oxygenase//F-box domain//zinc-finger C2H2-type GO:0055114//GO:0008152//GO:0019310 oxidation-reduction process//metabolic process//inositol catabolic process GO:0046872//GO:0050113//GO:0005506//GO:0016757//GO:0005515 metal ion binding//inositol oxygenase activity//iron ion binding//transferase activity, transferring glycosyl groups//protein binding GO:0005737 cytoplasm KOG1573 Aldehyde reductase Cluster-8309.35827 BF_2 4430.00 91.34 2316 751657249 AJF94883.1 2255 5.0e-251 C1 family cathepsin L11 [Tenebrio molitor] 801381562 XM_012198882.1 120 2.04976e-53 PREDICTED: Atta cephalotes digestive cysteine proteinase 1 (LOC105617316), mRNA -- -- -- -- P13277 627 1.2e-63 Digestive cysteine proteinase 1 OS=Homarus americanus GN=LCP1 PE=1 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.35828 BF_2 3401.75 199.63 1000 264667343 ACY71257.1 1048 1.9e-111 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 558 5.3e-56 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF03868//PF01159 Ribosomal protein L6, N-terminal domain//Ribosomal protein L6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1694 60s ribosomal protein L6 Cluster-8309.35832 BF_2 1661.56 47.65 1746 478252606 ENN73011.1 995 4.8e-105 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 755890983 XM_005189166.2 182 5.26282e-88 PREDICTED: Musca domestica cdc42 homolog (LOC101898849), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q17031 953 1.5e-101 Cdc42 homolog OS=Anopheles gambiae GN=Cdc42 PE=2 SV=2 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.35833 BF_2 880.65 40.80 1190 478252801 ENN73192.1 937 1.7e-98 hypothetical protein YQE_10171, partial [Dendroctonus ponderosae] 462301115 APGK01050708.1 87 2.29488e-35 Dendroctonus ponderosae Seq01050718, whole genome shotgun sequence -- -- -- -- Q969T9 407 2.0e-38 WW domain-binding protein 2 OS=Homo sapiens GN=WBP2 PE=1 SV=1 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding -- -- KOG3294 WW domain binding protein WBP-2, contains GRAM domain Cluster-8309.35834 BF_2 40.30 0.33 5389 642935129 XP_008197899.1 458 2.7e-42 PREDICTED: RNA-binding protein cabeza [Tribolium castaneum] -- -- -- -- -- K14651 TAF15, NPL3 transcription initiation factor TFIID subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K14651 Q27294 374 6.2e-34 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF00076//PF00641 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG1995 Conserved Zn-finger protein Cluster-8309.35836 BF_2 10.28 0.34 1546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35837 BF_2 2177.44 16.53 5796 642936633 XP_008198516.1 2964 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936634 XM_008200295.1 347 3.35166e-179 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X2, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 1.8e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF02262//PF04513//PF01496//PF06009//PF04111//PF15182 CBL proto-oncogene N-terminal domain 1//Baculovirus polyhedron envelope protein, PEP, C terminus//V-type ATPase 116kDa subunit family//Laminin Domain II//Autophagy protein Apg6//Otospiralin GO:0015991//GO:0007605//GO:0006914//GO:0007165//GO:0007166//GO:0015992//GO:0007155 ATP hydrolysis coupled proton transport//sensory perception of sound//autophagy//signal transduction//cell surface receptor signaling pathway//proton transport//cell adhesion GO:0005198//GO:0015078//GO:0004871 structural molecule activity//hydrogen ion transmembrane transporter activity//signal transducer activity GO:0019031//GO:0005634//GO:0019028//GO:0033179 viral envelope//nucleus//viral capsid//proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.35839 BF_2 17.36 0.51 1718 91095219 XP_969883.1 655 1.2e-65 PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940081|ref|XP_008192927.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940083|ref|XP_008192931.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|270016019|gb|EFA12467.1| hypothetical protein TcasGA2_TC010611 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q765P3 502 2.8e-49 Peptidoglycan-recognition protein 2 OS=Holotrichia diomphalia GN=PGRP-2 PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009253//GO:0006807//GO:0009252 peptidoglycan catabolic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.3584 BF_2 3.00 0.36 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35841 BF_2 452.83 10.42 2105 642915997 XP_008190849.1 2034 1.9e-225 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O01761 400 2.3e-37 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00041//PF13895//PF06220 Fibronectin type III domain//Immunoglobulin domain//U1 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.35843 BF_2 47.75 0.59 3666 189238490 XP_001809098.1 1159 9.6e-124 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|642926357|ref|XP_008194892.1| PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08799 136 1.7e-06 Myosin-2 heavy chain OS=Dictyostelium discoideum GN=mhcA PE=1 SV=3 PF04799//PF09726//PF07973//PF02205//PF04615//PF08702 fzo-like conserved region//Transmembrane protein//Threonyl and Alanyl tRNA synthetase second additional domain//WH2 motif//Utp14 protein//Fibrinogen alpha/beta chain family GO:0007165//GO:0051258//GO:0006364//GO:0008053//GO:0030168//GO:0043039 signal transduction//protein polymerization//rRNA processing//mitochondrial fusion//platelet activation//tRNA aminoacylation GO:0005524//GO:0003779//GO:0003924//GO:0005102//GO:0016876//GO:0030674 ATP binding//actin binding//GTPase activity//receptor binding//ligase activity, forming aminoacyl-tRNA and related compounds//protein binding, bridging GO:0016021//GO:0005577//GO:0032040//GO:0005741 integral component of membrane//fibrinogen complex//small-subunit processome//mitochondrial outer membrane -- -- Cluster-8309.35844 BF_2 35.76 1.24 1494 751447415 XP_011177845.1 246 2.9e-18 PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751447417|ref|XP_011177846.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera cucurbitae]>gi|751797807|ref|XP_011208789.1| PREDICTED: cytochrome c oxidase subunit 7C, mitochondrial-like [Bactrocera dorsalis] -- -- -- -- -- K02272 COX7C cytochrome c oxidase subunit 7c http://www.genome.jp/dbget-bin/www_bget?ko:K02272 P00430 136 6.8e-07 Cytochrome c oxidase subunit 7C, mitochondrial OS=Bos taurus GN=COX7C PE=1 SV=3 PF02935 Cytochrome c oxidase subunit VIIc GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.35845 BF_2 4147.22 25.75 7024 91079915 XP_967163.1 3071 0.0e+00 PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|642918342|ref|XP_008196887.1| PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|270003264|gb|EEZ99711.1| hypothetical protein TcasGA2_TC002472 [Tribolium castaneum] 642918341 XM_008198665.1 668 0 PREDICTED: Tribolium castaneum cold shock domain-containing protein E1 (LOC655517), transcript variant X2, mRNA -- -- -- -- P18395 1330 1.1e-144 Cold shock domain-containing protein E1 OS=Rattus norvegicus GN=Csde1 PE=2 SV=1 PF00313//PF02099 'Cold-shock' DNA-binding domain//Josephin GO:0006355 regulation of transcription, DNA-templated GO:0008242//GO:0003677 omega peptidase activity//DNA binding -- -- KOG2935 Ataxin 3/Josephin Cluster-8309.35846 BF_2 24.24 0.69 1746 332372484 AEE61384.1 1393 3.4e-151 unknown [Dendroctonus ponderosae]>gi|478263185|gb|ENN81578.1| hypothetical protein YQE_02107, partial [Dendroctonus ponderosae]>gi|546681813|gb|ERL91839.1| hypothetical protein D910_09164 [Dendroctonus ponderosae] 702073666 FO906013.1 51 3.49717e-15 Leptosphaeria maculans lepidii ibcn84_scaffold00011 complete sequence K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P12345 1082 1.6e-116 Aspartate aminotransferase, mitochondrial OS=Oryctolagus cuniculus GN=GOT2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.35848 BF_2 4107.50 44.38 4159 642926377 XP_008194900.1 1602 4.7e-175 PREDICTED: serine proteinase stubble [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17538 263 3.5e-21 Chymotrypsinogen B OS=Homo sapiens GN=CTRB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.35850 BF_2 287.89 9.79 1517 642918278 XP_967503.3 720 3.2e-73 PREDICTED: nucleoside diphosphate kinase [Tribolium castaneum] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P08879 629 4.7e-64 Nucleoside diphosphate kinase OS=Drosophila melanogaster GN=awd PE=1 SV=3 PF00334 Nucleoside diphosphate kinase GO:0006183//GO:0006228//GO:0006165//GO:0006241//GO:0006206//GO:0006144 GTP biosynthetic process//UTP biosynthetic process//nucleoside diphosphate phosphorylation//CTP biosynthetic process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.35851 BF_2 8.00 0.53 921 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35853 BF_2 14071.80 373.08 1865 14028771 AAK52496.1 146 1.4e-06 chymotrypsin inhibitor CI-b1 [Bombyx mori] -- -- -- -- -- -- -- -- -- P10832 146 5.9e-08 Chymotrypsin inhibitor SCI-II OS=Bombyx mori PE=1 SV=1 PF00014//PF12567//PF07127 Kunitz/Bovine pancreatic trypsin inhibitor domain//Leukocyte receptor CD45//Late nodulin protein GO:0006470//GO:0006570//GO:0050852//GO:0009878 protein dephosphorylation//tyrosine metabolic process//T cell receptor signaling pathway//nodule morphogenesis GO:0004725//GO:0046872//GO:0004867 protein tyrosine phosphatase activity//metal ion binding//serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.35855 BF_2 1082.69 15.07 3293 189234512 XP_972107.2 2248 4.6e-250 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X2 [Tribolium castaneum] 642913556 XM_967014.3 667 0 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X2, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 1249 1.3e-135 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF00324//PF04544//PF01194//PF13520 Amino acid permease//Herpesvirus egress protein UL20//RNA polymerases N / 8 kDa subunit//Amino acid permease GO:0006351//GO:0006865//GO:0055085//GO:0006144//GO:0019058//GO:0006810//GO:0003333//GO:0006206 transcription, DNA-templated//amino acid transport//transmembrane transport//purine nucleobase metabolic process//viral life cycle//transport//amino acid transmembrane transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0015171//GO:0003677 DNA-directed RNA polymerase activity//amino acid transmembrane transporter activity//DNA binding GO:0016020//GO:0005730 membrane//nucleolus -- -- Cluster-8309.35856 BF_2 4841.16 169.64 1481 801376388 XP_012064022.1 747 2.3e-76 PREDICTED: calmodulin [Atta cephalotes] 642914577 XM_967063.3 531 0 PREDICTED: Tribolium castaneum calmodulin (LOC660864), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 Q8STF0 744 2.1e-77 Calmodulin OS=Strongylocentrotus intermedius PE=2 SV=3 PF10104//PF13405//PF10591//PF13833//PF13499//PF12763//PF02563//PF03874//PF00036//PF13202 Di-sulfide bridge nucleocytoplasmic transport domain//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//Polysaccharide biosynthesis/export protein//RNA polymerase Rpb4//EF hand//EF hand GO:0006206//GO:0006351//GO:0006144//GO:0015774//GO:0007165//GO:0006998//GO:0006611//GO:0006406 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//polysaccharide transport//signal transduction//nuclear envelope organization//protein export from nucleus//mRNA export from nucleus GO:0005509//GO:0015159//GO:0005515//GO:0003899 calcium ion binding//polysaccharide transmembrane transporter activity//protein binding//DNA-directed RNA polymerase activity GO:0016020//GO:0005578//GO:0005730//GO:0031965 membrane//proteinaceous extracellular matrix//nucleolus//nuclear membrane KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35857 BF_2 6920.14 69.54 4450 302371202 NP_001180578.1 1511 1.8e-164 Z9 acyl-CoA desaturase B [Tribolium castaneum]>gi|642938808|ref|XP_008199928.1| PREDICTED: Z9 acyl-CoA desaturase B isoform X1 [Tribolium castaneum]>gi|642938810|ref|XP_008199929.1| PREDICTED: Z9 acyl-CoA desaturase B isoform X1 [Tribolium castaneum]>gi|270015965|gb|EFA12413.1| hypothetical protein TcasGA2_TC016415 [Tribolium castaneum]>gi|300432600|gb|ADK13055.1| Z9 acyl-CoA desaturase B [Tribolium castaneum] -- -- -- -- -- K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 Q6US81 1006 2.6e-107 Acyl-CoA Delta(11) desaturase OS=Spodoptera littoralis PE=1 SV=1 PF05371//PF00487 Phage major coat protein, Gp8//Fatty acid desaturase GO:0006633//GO:0055114//GO:0006629 fatty acid biosynthetic process//oxidation-reduction process//lipid metabolic process GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.35858 BF_2 259.08 20.49 816 571330966 AHF27415.1 790 1.3e-81 putative sugar transporter 3_1 [Phaedon cochleariae]>gi|571330968|gb|AHF27416.1| putative sugar transporter 3_2 [Phaedon cochleariae] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 P58354 307 5.5e-27 Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus GN=SLC2A8 PE=2 SV=2 PF00083//PF01769//PF07690 Sugar (and other) transporter//Divalent cation transporter//Major Facilitator Superfamily GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0022857//GO:0008324 transmembrane transporter activity//cation transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.35859 BF_2 752.00 43.46 1011 91093903 XP_969673.1 498 1.2e-47 PREDICTED: translocon-associated protein subunit delta [Tribolium castaneum]>gi|270014509|gb|EFA10957.1| hypothetical protein TcasGA2_TC004117 [Tribolium castaneum] -- -- -- -- -- K04571 SSR4 translocon-associated protein subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K04571 Q62186 245 1.1e-19 Translocon-associated protein subunit delta OS=Mus musculus GN=Ssr4 PE=2 SV=1 PF08030//PF05404 Ferric reductase NAD binding domain//Translocon-associated protein, delta subunit precursor (TRAP-delta) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG4088 Translocon-associated complex TRAP, delta subunit Cluster-8309.35860 BF_2 1472.00 18.59 3599 270007818 EFA04266.1 747 5.6e-76 hypothetical protein TcasGA2_TC014556 [Tribolium castaneum] 667677333 AE014297.3 74 1.19266e-27 Drosophila melanogaster chromosome 3R -- -- -- -- P41046 268 8.1e-22 Centrosomal and chromosomal factor OS=Drosophila melanogaster GN=corto PE=1 SV=2 PF04685 Protein of unknown function, DUF608 GO:0006687//GO:0005975//GO:0006665//GO:0006807 glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process//nitrogen compound metabolic process GO:0004348 glucosylceramidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.35862 BF_2 34.40 1.08 1614 531450771 AGT57862.1 531 2.8e-51 cytochrome P450 347c1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964T2 389 3.4e-36 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.35863 BF_2 16488.17 205.11 3650 91075960 XP_969014.1 2170 5.6e-241 PREDICTED: sarcalumenin [Tribolium castaneum]>gi|270014655|gb|EFA11103.1| hypothetical protein TcasGA2_TC004701 [Tribolium castaneum] 642910282 XM_963921.3 115 1.95396e-50 PREDICTED: Tribolium castaneum sarcalumenin (LOC657463), mRNA -- -- -- -- Q7TQ48 1007 1.7e-107 Sarcalumenin OS=Mus musculus GN=Srl PE=1 SV=1 PF07382//PF01926//PF03193 Histone H1-like nucleoprotein HC2//50S ribosome-binding GTPase//Protein of unknown function, DUF258 GO:0030261//GO:0006184 chromosome condensation//obsolete GTP catabolic process GO:0003924//GO:0005525//GO:0003677 GTPase activity//GTP binding//DNA binding -- -- KOG1954 Endocytosis/signaling protein EHD1 Cluster-8309.35864 BF_2 2078.83 21.04 4420 646714946 KDR18732.1 4412 0.0e+00 Xanthine dehydrogenase [Zootermopsis nevadensis] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P10351 4033 0.0e+00 Xanthine dehydrogenase OS=Drosophila melanogaster GN=ry PE=2 SV=2 PF00111//PF01799//PF00941//PF02738 2Fe-2S iron-sulfur cluster binding domain//[2Fe-2S] binding domain//FAD binding domain in molybdopterin dehydrogenase//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0051536//GO:0009055//GO:0016491//GO:0046872 iron-sulfur cluster binding//electron carrier activity//oxidoreductase activity//metal ion binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.35865 BF_2 15153.02 257.59 2748 815792945 XP_012217083.1 2629 2.5e-294 PREDICTED: endoplasmin [Linepithema humile] 332376397 BT128381.1 577 0 Dendroctonus ponderosae clone DPO089_B16 unknown mRNA K09487 HSP90B, TRA1 heat shock protein 90kDa beta http://www.genome.jp/dbget-bin/www_bget?ko:K09487 Q22235 2113 7.1e-236 Endoplasmin homolog OS=Caenorhabditis elegans GN=enpl-1 PE=3 SV=1 PF15050//PF00183 SCIMP protein//Hsp90 protein GO:0006457//GO:0006950 protein folding//response to stress GO:0051082//GO:0005524 unfolded protein binding//ATP binding GO:0001772//GO:0016021//GO:0097197 immunological synapse//integral component of membrane//tetraspanin-enriched microdomain KOG0020 Endoplasmic reticulum glucose-regulated protein (GRP94/endoplasmin), HSP90 family Cluster-8309.35866 BF_2 238.39 1.24 8349 189236706 XP_974173.2 1532 1.2e-166 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 349 3.73777e-180 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 652 5.6e-66 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.35868 BF_2 842.04 6.08 6084 189236215 XP_975776.2 2722 9.2e-305 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 1.04281e-134 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 921 2.6e-97 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.35869 BF_2 273.00 12.85 1176 91085813 XP_974738.1 535 7.0e-52 PREDICTED: YY1-associated factor 2 [Tribolium castaneum]>gi|270010133|gb|EFA06581.1| hypothetical protein TcasGA2_TC009493 [Tribolium castaneum] -- -- -- -- -- K11468 YAF2 YY1-associated factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11468 Q99LW6 338 2.0e-30 YY1-associated factor 2 OS=Mus musculus GN=Yaf2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- KOG4477 RING1 interactor RYBP and related Zn-finger-containing proteins Cluster-8309.35870 BF_2 480.43 6.68 3297 642926804 XP_008195020.1 1279 1.1e-137 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 4.93689e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q6INE8 937 2.0e-99 Vacuole membrane protein 1 OS=Xenopus laevis GN=vmp1 PE=2 SV=1 PF00323 Mammalian defensin GO:0006952 defense response -- -- GO:0005576 extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.35872 BF_2 247.62 7.35 1696 91080051 XP_973222.1 891 5.3e-93 PREDICTED: protein lin-7 homolog C [Tribolium castaneum]>gi|270003212|gb|EEZ99659.1| hypothetical protein TcasGA2_TC002416 [Tribolium castaneum] 805812653 XM_012292327.1 199 1.81172e-97 PREDICTED: Megachile rotundata protein lin-7 homolog C (LOC100884077), transcript variant X5, mRNA -- -- -- -- Q5F425 746 1.4e-77 Protein lin-7 homolog C OS=Gallus gallus GN=LIN7C PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.35873 BF_2 55.62 0.57 4334 642933803 XP_008197345.1 467 2.0e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 8.18225e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q9CZG3 131 7.5e-06 COMM domain-containing protein 8 OS=Mus musculus GN=Commd8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35875 BF_2 862.87 51.58 987 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08145 BOP1NT (NUC169) domain GO:0006364 rRNA processing -- -- -- -- -- -- Cluster-8309.35877 BF_2 69.43 2.02 1724 270001643 EEZ98090.1 372 8.2e-33 hypothetical protein TcasGA2_TC000503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26352 128 6.6e-06 Thymosin beta-12 OS=Oncorhynchus mykiss PE=1 SV=2 PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- KOG4794 Thymosin beta Cluster-8309.35878 BF_2 204.00 5.01 1990 270001855 EEZ98302.1 519 8.5e-50 hypothetical protein TcasGA2_TC000755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5M3 296 2.5e-25 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.35880 BF_2 3350.82 1693.44 367 835482914 AKM70276.1 143 6.2e-07 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35881 BF_2 7475.60 134.11 2619 546686007 ERL95413.1 3162 0.0e+00 hypothetical protein D910_12677 [Dendroctonus ponderosae] 288872186 NM_001172404.1 254 7.51072e-128 Apis mellifera NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) (Ndufs1), mRNA K03934 NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03934 Q94511 2538 3.5e-285 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial OS=Drosophila melanogaster GN=ND75 PE=2 SV=3 PF10588//PF00111//PF09326//PF00384//PF00205//PF00211 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//2Fe-2S iron-sulfur cluster binding domain//NADH-ubiquinone oxidoreductase subunit G, C-terminal//Molybdopterin oxidoreductase//Thiamine pyrophosphate enzyme, central domain//Adenylate and Guanylate cyclase catalytic domain GO:0055114//GO:0035556//GO:0009190//GO:0006118 oxidation-reduction process//intracellular signal transduction//cyclic nucleotide biosynthetic process//obsolete electron transport GO:0016849//GO:0030976//GO:0000287//GO:0009055//GO:0051536//GO:0016651//GO:0016491 phosphorus-oxygen lyase activity//thiamine pyrophosphate binding//magnesium ion binding//electron carrier activity//iron-sulfur cluster binding//oxidoreductase activity, acting on NAD(P)H//oxidoreductase activity -- -- KOG2282 NADH-ubiquinone oxidoreductase, NDUFS1/75 kDa subunit Cluster-8309.35882 BF_2 884.00 14.49 2839 642930706 XP_008199995.1 1616 7.6e-177 PREDICTED: hepatocyte growth factor-regulated tyrosine kinase substrate [Tribolium castaneum]>gi|270012668|gb|EFA09116.1| hypothetical protein TcasGA2_TC015976 [Tribolium castaneum] -- -- -- -- -- K12182 HGS, HRS, VPS27 hepatocyte growth factor-regulated tyrosine kinase substrate http://www.genome.jp/dbget-bin/www_bget?ko:K12182 Q960X8 1213 1.7e-131 Hepatocyte growth factor-regulated tyrosine kinase substrate OS=Drosophila melanogaster GN=Hrs PE=1 SV=1 PF01363//PF04632//PF00790 FYVE zinc finger//Fusaric acid resistance protein family//VHS domain GO:0006810//GO:0006886 transport//intracellular protein transport GO:0046872 metal ion binding GO:0005886 plasma membrane KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.35883 BF_2 14353.48 965.59 909 264667343 ACY71257.1 1048 1.8e-111 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 558 4.8e-56 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF01159//PF03868 Ribosomal protein L6e//Ribosomal protein L6, N-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-8309.35884 BF_2 4961.00 473.98 725 270008722 EFA05170.1 453 1.4e-42 hypothetical protein TcasGA2_TC015299 [Tribolium castaneum] 264667356 GU120414.1 143 1.01757e-66 Chrysomela tremulae ribosomal protein S27 (RpS27) mRNA, complete cds K02978 RP-S27e, RPS27 small subunit ribosomal protein S27e http://www.genome.jp/dbget-bin/www_bget?ko:K02978 Q6ZWU9 380 1.7e-35 40S ribosomal protein S27 OS=Mus musculus GN=Rps27 PE=1 SV=3 PF01667 Ribosomal protein S27 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1779 40s ribosomal protein S27 Cluster-8309.35885 BF_2 48.10 0.55 3967 546683529 ERL93331.1 164 2.5e-08 hypothetical protein D910_10625, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35887 BF_2 161.75 1.27 5630 642924614 XP_008194364.1 1949 3.7e-215 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 7.8e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.35888 BF_2 443.91 92.84 487 821003176 XP_012365190.1 807 8.4e-84 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 46359621 AB122067.1 253 4.74913e-128 Crassostrea gigas mRNA for polyubiquitin, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 807 3.4e-85 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF00240//PF14560//PF04452 Ubiquitin family//Ubiquitin-like domain//RNA methyltransferase GO:0006364 rRNA processing GO:0008168//GO:0005515 methyltransferase activity//protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.35889 BF_2 475.00 6.08 3555 642911172 XP_008200610.1 1338 1.6e-144 PREDICTED: E3 ubiquitin-protein ligase KCMF1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P0J7 813 5.1e-85 E3 ubiquitin-protein ligase KCMF1 OS=Homo sapiens GN=KCMF1 PE=1 SV=2 PF00569//PF00096 Zinc finger, ZZ type//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1280 Uncharacterized conserved protein containing ZZ-type Zn-finger Cluster-8309.35890 BF_2 20009.22 1489.82 849 91084673 XP_968064.1 1123 3.3e-120 PREDICTED: 40S ribosomal protein S3a [Tribolium castaneum]>gi|270008925|gb|EFA05373.1| hypothetical protein TcasGA2_TC015539 [Tribolium castaneum] 70909476 AM048925.1 266 5.05731e-135 Timarcha balearica mRNA for ribosomal protein S3Ae (rpS3Ae gene) K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 Q5G5C4 1113 2.0e-120 40S ribosomal protein S3a OS=Periplaneta americana GN=Parcxpwex01 PE=2 SV=1 PF01015//PF04083 Ribosomal S3Ae family//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0006412//GO:0042254 lipid metabolic process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1628 40S ribosomal protein S3A Cluster-8309.35891 BF_2 7.14 0.36 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35892 BF_2 61055.86 1725.94 1767 91081963 XP_975913.1 514 2.9e-49 PREDICTED: nuclease-sensitive element-binding protein 1 isoform X2 [Tribolium castaneum] 642921885 XM_961501.3 225 6.65194e-112 PREDICTED: Tribolium castaneum Y-box factor homolog (LOC656063), transcript variant X1, mRNA K06099 CSDA, ZONAB cold shock domain protein A http://www.genome.jp/dbget-bin/www_bget?ko:K06099 P41824 393 1.3e-36 Y-box factor homolog OS=Aplysia californica PE=2 SV=1 PF00313//PF00621 'Cold-shock' DNA-binding domain//RhoGEF domain GO:0006355//GO:0035023//GO:0043087 regulation of transcription, DNA-templated//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0003677//GO:0005089 DNA binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.35893 BF_2 1588.86 40.41 1932 270013857 EFA10305.1 192 6.8e-12 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35894 BF_2 28.29 0.62 2210 646682520 KDR02319.1 1275 2.1e-137 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.56435e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 934 2.9e-99 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF07714//PF00937//PF00069 Protein tyrosine kinase//Coronavirus nucleocapsid protein//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.35895 BF_2 16104.00 118.40 5977 665798417 XP_008547083.1 2016 6.6e-223 PREDICTED: collagen alpha-1(IV) chain [Microplitis demolitor] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 P02462 1845 1.8e-204 Collagen alpha-1(IV) chain OS=Homo sapiens GN=COL4A1 PE=1 SV=3 PF12529//PF01413//PF02948 Xylosyltransferase C terminal//C-terminal tandem repeated domain in type 4 procollagen//Amelogenin GO:0006024//GO:0030206//GO:0007275 glycosaminoglycan biosynthetic process//chondroitin sulfate biosynthetic process//multicellular organismal development GO:0030158//GO:0005201 protein xylosyltransferase activity//extracellular matrix structural constituent GO:0005581//GO:0005578 collagen trimer//proteinaceous extracellular matrix KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.35896 BF_2 155.00 5.97 1373 478254585 ENN74828.1 554 5.1e-54 hypothetical protein YQE_08601, partial [Dendroctonus ponderosae]>gi|546671540|gb|ERL83809.1| hypothetical protein D910_01058 [Dendroctonus ponderosae]>gi|546680245|gb|ERL90561.1| hypothetical protein D910_07909 [Dendroctonus ponderosae] 641673954 XM_003246814.2 57 1.2634e-18 PREDICTED: Acyrthosiphon pisum protein Dr1 (LOC100161049), transcript variant X2, mRNA -- -- -- -- Q9VJQ5 465 4.4e-45 Protein Dr1 OS=Drosophila melanogaster GN=NC2beta PE=1 SV=1 PF00125//PF15510//PF05634 Core histone H2A/H2B/H3/H4//Centromere kinetochore component W//APO RNA-binding GO:0051382//GO:0007067 kinetochore assembly//mitotic nuclear division GO:0003723//GO:0003677 RNA binding//DNA binding -- -- KOG0871 Class 2 transcription repressor NC2, beta subunit (Dr1) Cluster-8309.35897 BF_2 18.83 0.60 1598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01673 Herpesvirus putative major envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.35898 BF_2 2152.10 94.88 1236 309318773 BAJ23047.1 605 5.6e-60 peptidoglycan-recognition protein-SC2 [Tenebrio molitor] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V4X2 412 5.5e-39 Peptidoglycan-recognition protein SC2 OS=Drosophila melanogaster GN=PGRP-SC2 PE=2 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0009253//GO:0006807 peptidoglycan biosynthetic process//peptidoglycan catabolic process//nitrogen compound metabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.35899 BF_2 920.04 8.72 4703 478263067 ENN81467.1 1338 2.2e-144 hypothetical protein YQE_02159, partial [Dendroctonus ponderosae] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 890 7.9e-94 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF07535//PF00067 DBF zinc finger//Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0003676//GO:0008270//GO:0016705 iron ion binding//heme binding//nucleic acid binding//zinc ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.3590 BF_2 1.12 0.70 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35903 BF_2 35.33 0.33 4767 512926764 XP_004931167.1 670 6.3e-67 PREDICTED: GTP-binding protein SAR1b [Bombyx mori] 676480291 XM_009063766.1 50 3.47681e-14 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q9QVY3 541 2.4e-53 GTP-binding protein SAR1b OS=Cricetulus griseus GN=SAR1B PE=1 SV=1 PF04670//PF00071//PF00503//PF06858//PF05493//PF08650//PF00025//PF08477 Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//Nucleolar GTP-binding protein 1 (NOG1)//ATP synthase subunit H//DASH complex subunit Dad4//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0015991//GO:0008608//GO:0007186//GO:0007264//GO:0015992 signal transduction//ATP hydrolysis coupled proton transport//attachment of spindle microtubules to kinetochore//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//proton transport GO:0031683//GO:0003924//GO:0019001//GO:0004871//GO:0015078//GO:0005525 G-protein beta/gamma-subunit complex binding//GTPase activity//guanyl nucleotide binding//signal transducer activity//hydrogen ion transmembrane transporter activity//GTP binding GO:0072686//GO:0042729//GO:0033179 mitotic spindle//DASH complex//proton-transporting V-type ATPase, V0 domain KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.35904 BF_2 41.39 2.09 1115 91082141 XP_969473.1 663 9.6e-67 PREDICTED: integral membrane protein 2A [Tribolium castaneum]>gi|270007252|gb|EFA03700.1| hypothetical protein TcasGA2_TC013805 [Tribolium castaneum] -- -- -- -- -- K18264 ITM2B integral membrane protein 2B http://www.genome.jp/dbget-bin/www_bget?ko:K18264 Q3T0P7 179 5.2e-12 Integral membrane protein 2B OS=Bos taurus GN=ITM2B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4681 Uncharacterized conserved protein Cluster-8309.35906 BF_2 303.16 10.04 1550 189240618 XP_001807780.1 402 2.4e-36 PREDICTED: uncharacterized protein LOC100142083 [Tribolium castaneum]>gi|642933744|ref|XP_008191491.1| PREDICTED: uncharacterized protein LOC100142083 [Tribolium castaneum]>gi|270013624|gb|EFA10072.1| hypothetical protein TcasGA2_TC012246 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35907 BF_2 1705.00 47.18 1799 478254039 ENN74331.1 1722 2.5e-189 hypothetical protein YQE_09301, partial [Dendroctonus ponderosae]>gi|546686147|gb|ERL95533.1| hypothetical protein D910_12795 [Dendroctonus ponderosae] -- -- -- -- -- K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q96I99 1211 1.8e-131 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial OS=Homo sapiens GN=SUCLG2 PE=1 SV=2 PF00549 CoA-ligase GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.35908 BF_2 598.02 12.02 2369 642920758 XP_971086.2 1029 7.4e-109 PREDICTED: protein-L-isoaspartate(D-aspartate) O-methyltransferase [Tribolium castaneum] 242014347 XM_002427808.1 67 6.08439e-24 Pediculus humanus corporis protein-L-isoaspartate O-methyltransferase, putative, mRNA K00573 E2.1.1.77, pcm protein-L-isoaspartate(D-aspartate) O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00573 Q5F3N1 775 8.6e-81 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Gallus gallus GN=PCMT1 PE=2 SV=3 PF01209//PF08241//PF01596//PF05175//PF01135 ubiE/COQ5 methyltransferase family//Methyltransferase domain//O-methyltransferase//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006464//GO:0008152//GO:0006479//GO:0046500 cellular protein modification process//metabolic process//protein methylation//S-adenosylmethionine metabolic process GO:0008168//GO:0008171//GO:0004719 methyltransferase activity//O-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity -- -- KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.35909 BF_2 283.62 1.47 8384 642935636 XP_008198092.1 4502 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 6.69387e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.5e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF13180//PF00620//PF00595//PF08718 PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF)//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0017089//GO:0051861//GO:0005515 glycolipid transporter activity//glycolipid binding//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.35910 BF_2 1158.90 31.50 1826 642915594 XP_008190680.1 1716 1.2e-188 PREDICTED: uncharacterized protein LOC655748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35911 BF_2 161.13 2.26 3271 91089643 XP_973832.1 1255 6.3e-135 PREDICTED: solute carrier family 25 member 38-A isoform X2 [Tribolium castaneum]>gi|270011349|gb|EFA07797.1| hypothetical protein TcasGA2_TC005358 [Tribolium castaneum] -- -- -- -- -- K15118 SLC25A38 solute carrier family 25, member 38 http://www.genome.jp/dbget-bin/www_bget?ko:K15118 Q08CI8 782 1.8e-81 Solute carrier family 25 member 38-A OS=Danio rerio GN=slc25a38a PE=2 SV=2 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0766 Predicted mitochondrial carrier protein Cluster-8309.35912 BF_2 181.28 1.02 7700 91082255 XP_973064.1 2364 3.8e-263 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62046 915 1.6e-96 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus GN=Lrch1 PE=1 SV=2 PF00560//PF13855//PF00307 Leucine Rich Repeat//Leucine rich repeat//Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.35913 BF_2 32.11 0.70 2215 91079642 XP_968121.1 1753 7.7e-193 PREDICTED: vacuolar protein sorting-associated protein 4B [Tribolium castaneum]>gi|270004475|gb|EFA00923.1| hypothetical protein TcasGA2_TC003829 [Tribolium castaneum] 346710885 AK385938.1 298 2.19979e-152 Bombyx mori mRNA, clone: fphe14F12 K12196 VPS4 vacuolar protein-sorting-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12196 Q9UN37 1491 7.6e-164 Vacuolar protein sorting-associated protein 4A OS=Homo sapiens GN=VPS4A PE=1 SV=1 PF01637//PF02562//PF00910//PF13414//PF00158//PF13304//PF06068//PF05496//PF04889//PF07728//PF01695//PF14532//PF07724//PF00004 Archaeal ATPase//PhoH-like protein//RNA helicase//TPR repeat//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Cwf15/Cwc15 cell cycle control protein//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0006355//GO:0000398//GO:0006281 DNA recombination//regulation of transcription, DNA-templated//mRNA splicing, via spliceosome//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0005515//GO:0016887//GO:0005524//GO:0008134 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//protein binding//ATPase activity//ATP binding//transcription factor binding GO:0005657//GO:0005681//GO:0005667//GO:0009379 replication fork//spliceosomal complex//transcription factor complex//Holliday junction helicase complex KOG0739 AAA+-type ATPase Cluster-8309.35914 BF_2 187.55 0.52 15490 642931869 XP_008196762.1 2259 1.1e-250 PREDICTED: protein split ends isoform X1 [Tribolium castaneum] 642931870 XM_008198541.1 278 2.0438e-140 PREDICTED: Tribolium castaneum protein split ends (LOC661278), transcript variant X2, mRNA -- -- -- -- Q8SX83 1148 3.2e-123 Protein split ends OS=Drosophila melanogaster GN=spen PE=1 SV=2 PF00076//PF02532//PF16367//PF04406//PF00335 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//RNA recognition motif//Type IIB DNA topoisomerase//Tetraspanin family GO:0015979//GO:0006259 photosynthesis//DNA metabolic process GO:0003824//GO:0005524//GO:0003677//GO:0003676 catalytic activity//ATP binding//DNA binding//nucleic acid binding GO:0016021//GO:0009539//GO:0009523//GO:0016020//GO:0005694 integral component of membrane//photosystem II reaction center//photosystem II//membrane//chromosome KOG0112 Large RNA-binding protein (RRM superfamily) Cluster-8309.35916 BF_2 431.59 3.63 5266 642925269 XP_008194486.1 1379 4.3e-149 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 790 3.5e-82 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF01542//PF03600//PF00939 Hepatitis C virus core protein//Citrate transporter//Sodium:sulfate symporter transmembrane region GO:0006814//GO:0055085//GO:0006810 sodium ion transport//transmembrane transport//transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.35917 BF_2 316.75 6.17 2436 728418241 AIY68362.1 267 1.7e-20 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05992 SbmA/BacA-like family GO:0006810 transport GO:0005215 transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.35918 BF_2 31.93 1.08 1528 546681363 ERL91473.1 1524 1.9e-166 hypothetical protein D910_08803 [Dendroctonus ponderosae] 817195914 XM_012418095.1 260 2.00478e-131 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1373 2.5e-150 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.35920 BF_2 305.50 5.99 2419 478262467 ENN81138.1 1535 1.6e-167 hypothetical protein YQE_02505, partial [Dendroctonus ponderosae] -- -- -- -- -- K14258 TRET1 facilitated trehalose transporter http://www.genome.jp/dbget-bin/www_bget?ko:K14258 B0WC46 1277 5.4e-139 Facilitated trehalose transporter Tret1 OS=Culex quinquefasciatus GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.35921 BF_2 136.80 1.06 5688 642910851 XP_008193435.1 1733 4.1e-190 PREDICTED: arginine kinase isoform X1 [Tribolium castaneum] 290048170 GU396008.1 405 0 Helicoverpa armigera arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 P48610 1581 7.2e-174 Arginine kinase OS=Drosophila melanogaster GN=Argk PE=2 SV=2 PF02807//PF00217 ATP:guanido phosphotransferase, N-terminal domain//ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.35923 BF_2 94.36 2.78 1707 642912979 XP_008201336.1 1347 7.1e-146 PREDICTED: leucine carboxyl methyltransferase 1 [Tribolium castaneum]>gi|270001907|gb|EEZ98354.1| hypothetical protein TcasGA2_TC000811 [Tribolium castaneum] -- -- -- -- -- K18203 LCMT1 http://www.genome.jp/dbget-bin/www_bget?ko:K18203 Q6P4Z6 721 1.1e-74 Leucine carboxyl methyltransferase 1 OS=Rattus norvegicus GN=Lcmt1 PE=2 SV=1 PF03764//PF04072 Elongation factor G, domain IV//Leucine carboxyl methyltransferase GO:0032259 methylation GO:0008168//GO:0005525 methyltransferase activity//GTP binding -- -- KOG2918 Carboxymethyl transferase Cluster-8309.35924 BF_2 707.69 15.66 2178 270007760 EFA04208.1 192 7.7e-12 hypothetical protein TcasGA2_TC014457, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PH91 152 1.4e-08 Single-pass membrane and coiled-coil domain-containing protein 4 homolog OS=Anopheles gambiae GN=AGAP003534 PE=3 SV=3 PF00522//PF00001 VPR/VPX protein//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0019058 G-protein coupled receptor signaling pathway//viral life cycle GO:0004930 G-protein coupled receptor activity GO:0042025//GO:0016021 host cell nucleus//integral component of membrane -- -- Cluster-8309.35925 BF_2 616.00 6.95 3997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00468 Ribosomal protein L34 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.35927 BF_2 72.49 2.32 1594 189234118 XP_001811130.1 634 3.2e-63 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] 153907106 AK262902.1 40 4.15126e-09 Gryllus bimaculatus mRNA, GBcontig09763 -- -- -- -- -- -- -- -- PF05757//PF09726 Oxygen evolving enhancer protein 3 (PsbQ)//Transmembrane protein GO:0015979 photosynthesis GO:0005509 calcium ion binding GO:0009523//GO:0016021//GO:0019898//GO:0009654 photosystem II//integral component of membrane//extrinsic component of membrane//photosystem II oxygen evolving complex -- -- Cluster-8309.35929 BF_2 215.38 8.13 1396 642913237 XP_008201451.1 717 6.5e-73 PREDICTED: zinc finger protein 830 [Tribolium castaneum] 828206332 XM_012701468.1 44 2.16573e-11 PREDICTED: Hydra vulgaris zinc finger protein 830-like (LOC100205964), mRNA K13104 ZNF830, CCDC16 zinc finger protein 830 http://www.genome.jp/dbget-bin/www_bget?ko:K13104 Q6DJ13 223 5.2e-17 Zinc finger protein 830 OS=Xenopus tropicalis GN=znf830 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3032 Uncharacterized conserved protein Cluster-8309.35930 BF_2 1544.00 66.94 1252 642911041 XP_967134.2 1283 1.4e-138 PREDICTED: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase-like [Tribolium castaneum] -- -- -- -- -- K00078 DHDH dihydrodiol dehydrogenase / D-xylose 1-dehydrogenase (NADP) http://www.genome.jp/dbget-bin/www_bget?ko:K00078 Q6DF30 746 1.0e-77 Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase OS=Xenopus tropicalis GN=dhdh PE=2 SV=1 PF02894//PF01408 Oxidoreductase family, C-terminal alpha/beta domain//Oxidoreductase family, NAD-binding Rossmann fold GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2741 Dimeric dihydrodiol dehydrogenase Cluster-8309.35931 BF_2 1158.85 17.56 3048 91077610 XP_973618.1 1737 7.6e-191 PREDICTED: branched-chain-amino-acid aminotransferase, cytosolic [Tribolium castaneum]>gi|270001557|gb|EEZ98004.1| hypothetical protein TcasGA2_TC000403 [Tribolium castaneum] -- -- -- -- -- K00826 E2.6.1.42, ilvE branched-chain amino acid aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00826 P54690 1007 1.4e-107 Branched-chain-amino-acid aminotransferase, cytosolic OS=Rattus norvegicus GN=Bcat1 PE=1 SV=1 PF01063 Amino-transferase class IV GO:0009099//GO:0009097//GO:0008152//GO:0009098 valine biosynthetic process//isoleucine biosynthetic process//metabolic process//leucine biosynthetic process GO:0052655//GO:0003824//GO:0052654//GO:0052656 L-valine transaminase activity//catalytic activity//L-leucine transaminase activity//L-isoleucine transaminase activity -- -- KOG0975 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily Cluster-8309.35934 BF_2 8806.23 59.57 6471 91093785 XP_967374.1 2861 0.0e+00 PREDICTED: DNA mismatch repair protein Msh2 [Tribolium castaneum]>gi|270015917|gb|EFA12365.1| hypothetical protein TcasGA2_TC002071 [Tribolium castaneum] -- -- -- -- -- K08735 MSH2 DNA mismatch repair protein MSH2 http://www.genome.jp/dbget-bin/www_bget?ko:K08735 Q5XXB5 2011 1.1e-223 DNA mismatch repair protein Msh2 OS=Chlorocebus aethiops GN=MSH2 PE=2 SV=1 PF06305//PF00488//PF08038//PF05190//PF05192//PF05188 Protein of unknown function (DUF1049)//MutS domain V//TOM7 family//MutS family domain IV//MutS domain III//MutS domain II GO:0030150//GO:0006298 protein import into mitochondrial matrix//mismatch repair GO:0097159//GO:0030983//GO:1901363//GO:0005524 organic cyclic compound binding//mismatched DNA binding//heterocyclic compound binding//ATP binding GO:0005742//GO:0032300//GO:0044428//GO:0005887 mitochondrial outer membrane translocase complex//mismatch repair complex//nuclear part//integral component of plasma membrane KOG0219 Mismatch repair ATPase MSH2 (MutS family) Cluster-8309.35935 BF_2 273.01 2.33 5192 237681145 NP_001153717.1 4861 0.0e+00 ATPase, class II, type 9B [Tribolium castaneum]>gi|642928770|ref|XP_008195554.1| PREDICTED: ATPase, class II, type 9B isoform X1 [Tribolium castaneum]>gi|270010392|gb|EFA06840.1| hypothetical protein TcasGA2_TC009783 [Tribolium castaneum] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3531 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF00122//PF09003 E1-E2 ATPase//Bacteriophage lambda integrase, N-terminal domain GO:0015914//GO:0008152//GO:0006812//GO:0015074//GO:0015917 phospholipid transport//metabolic process//cation transport//DNA integration//aminophospholipid transport GO:0003677//GO:0005524//GO:0015662//GO:0004012//GO:0000166//GO:0008907//GO:0000287//GO:0046872 DNA binding//ATP binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//phospholipid-translocating ATPase activity//nucleotide binding//integrase activity//magnesium ion binding//metal ion binding GO:0016021 integral component of membrane KOG0210 P-type ATPase Cluster-8309.35936 BF_2 551.96 14.11 1924 478254712 ENN74953.1 1315 4.1e-142 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 1323 2.0e-144 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF15886//PF00722 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0030246//GO:0004553 carbohydrate binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.35937 BF_2 17.00 2.46 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35938 BF_2 276.47 2.17 5620 826467549 XP_012535467.1 2089 2.1e-231 PREDICTED: glutamate dehydrogenase, mitochondrial [Monomorium pharaonis] 195573296 XM_002104594.1 246 4.54332e-123 Drosophila simulans GD18335 (Dsim\GD18335), mRNA K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 1924 1.2e-213 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF02812//PF00208//PF02826 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491//GO:0051287 oxidoreductase activity//NAD binding -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.35939 BF_2 1651.97 16.97 4360 642925269 XP_008194486.1 1379 3.5e-149 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 790 2.9e-82 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF03600//PF01542//PF00939 Citrate transporter//Hepatitis C virus core protein//Sodium:sulfate symporter transmembrane region GO:0006814//GO:0055085//GO:0006810 sodium ion transport//transmembrane transport//transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.3594 BF_2 3.00 0.68 471 642914921 XP_972109.2 462 8.2e-44 PREDICTED: NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q93873 384 3.7e-36 Probable NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Caenorhabditis elegans GN=gas-1 PE=3 SV=2 PF00346//PF00374 Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Nickel-dependent hydrogenase GO:0055114 oxidation-reduction process GO:0016651//GO:0048038//GO:0051287//GO:0016151 oxidoreductase activity, acting on NAD(P)H//quinone binding//NAD binding//nickel cation binding -- -- KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-8309.35940 BF_2 42.07 0.34 5477 642925269 XP_008194486.1 926 1.5e-96 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 517 1.6e-50 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF03600//PF01542//PF00939 Citrate transporter//Hepatitis C virus core protein//Sodium:sulfate symporter transmembrane region GO:0055085//GO:0006814//GO:0006810 transmembrane transport//sodium ion transport//transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.35941 BF_2 1479.85 7.05 9070 270010611 EFA07059.1 1520 3.3e-165 hypothetical protein TcasGA2_TC010036 [Tribolium castaneum] 189239538 XM_970519.2 261 3.37031e-131 PREDICTED: Tribolium castaneum ras-related protein Rab-23 (LOC664521), mRNA K06234 RAB23 Ras-related protein Rab-23 http://www.genome.jp/dbget-bin/www_bget?ko:K06234 Q9ULC3 552 2.4e-54 Ras-related protein Rab-23 OS=Homo sapiens GN=RAB23 PE=1 SV=1 PF03193//PF04670//PF10662//PF00071//PF08477//PF00735//PF01926//PF12106//PF02421//PF00025 Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//Colicin C terminal ribonuclease domain//Ferrous iron transport protein B//ADP-ribosylation factor family GO:0006576//GO:0007264//GO:0015684//GO:0051252 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport//regulation of RNA metabolic process GO:0015093//GO:0005524//GO:0003924//GO:0004540//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//ribonuclease activity//GTP binding GO:0016021 integral component of membrane KOG0079 GTP-binding protein H-ray, small G protein superfamily Cluster-8309.35942 BF_2 538.86 13.00 2021 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17056 Killer toxin-resistance protein 1 GO:0031505 fungal-type cell wall organization -- -- -- -- -- -- Cluster-8309.35943 BF_2 5014.14 72.53 3179 642936524 XP_008198472.1 3435 0.0e+00 PREDICTED: transmembrane GTPase Marf [Tribolium castaneum]>gi|642936526|ref|XP_970147.2| PREDICTED: transmembrane GTPase Marf [Tribolium castaneum] 462318797 APGK01044284.1 207 1.22392e-101 Dendroctonus ponderosae Seq01044294, whole genome shotgun sequence K06030 MFN mitofusin http://www.genome.jp/dbget-bin/www_bget?ko:K06030 Q7YU24 2272 3.0e-254 Transmembrane GTPase Marf OS=Drosophila melanogaster GN=Marf PE=1 SV=1 PF01926//PF04799//PF11734 50S ribosome-binding GTPase//fzo-like conserved region//TilS substrate C-terminal domain GO:0008053//GO:0008033 mitochondrial fusion//tRNA processing GO:0005524//GO:0003924//GO:0016879//GO:0000166//GO:0005525 ATP binding//GTPase activity//ligase activity, forming carbon-nitrogen bonds//nucleotide binding//GTP binding GO:0016021//GO:0005741//GO:0005737 integral component of membrane//mitochondrial outer membrane//cytoplasm KOG0448 Mitofusin 1 GTPase, involved in mitochondrila biogenesis Cluster-8309.35944 BF_2 1364.74 55.44 1317 478260464 ENN80184.1 1226 5.9e-132 hypothetical protein YQE_03380, partial [Dendroctonus ponderosae]>gi|546674446|gb|ERL85820.1| hypothetical protein D910_03235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P301 681 3.8e-70 Protein YIF1B OS=Xenopus tropicalis GN=yif1b PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG3094 Predicted membrane protein Cluster-8309.35946 BF_2 2045.00 93.72 1200 780654779 XP_011691311.1 188 1.2e-11 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X2 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- P22700 127 6.0e-06 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35947 BF_2 233.30 3.80 2855 91092022 XP_970951.1 743 1.3e-75 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 629 8.8e-64 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.35948 BF_2 4331.77 42.00 4602 546675246 ERL86482.1 738 7.9e-75 hypothetical protein D910_03887 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305//PF08038 Protein of unknown function (DUF1049)//TOM7 family GO:0030150 protein import into mitochondrial matrix -- -- GO:0005887//GO:0005742 integral component of plasma membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.35949 BF_2 31.31 1.14 1437 91081621 XP_966892.1 986 4.3e-104 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54P77 593 6.6e-60 Probable 4-coumarate--CoA ligase 1 OS=Dictyostelium discoideum GN=4cl1 PE=3 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.35950 BF_2 892.44 22.37 1956 642936923 XP_970894.2 931 1.4e-97 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 Q94527 510 3.8e-50 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.35951 BF_2 3497.21 110.34 1613 91084535 XP_972884.1 2160 3.6e-240 PREDICTED: NADH-ubiquinone oxidoreductase 49 kDa subunit [Tribolium castaneum]>gi|270009249|gb|EFA05697.1| hypothetical protein TcasGA2_TC015217 [Tribolium castaneum] 642925604 XM_967791.3 288 5.76767e-147 PREDICTED: Tribolium castaneum NADH-ubiquinone oxidoreductase 49 kDa subunit (LOC661641), mRNA K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q641Y2 1842 1.1e-204 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial OS=Rattus norvegicus GN=Ndufs2 PE=1 SV=1 PF00374//PF00165//PF00346 Nickel-dependent hydrogenase//Bacterial regulatory helix-turn-helix proteins, AraC family//Respiratory-chain NADH dehydrogenase, 49 Kd subunit GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0003700//GO:0048038//GO:0043565//GO:0016151//GO:0051287//GO:0016651 transcription factor activity, sequence-specific DNA binding//quinone binding//sequence-specific DNA binding//nickel cation binding//NAD binding//oxidoreductase activity, acting on NAD(P)H GO:0005667 transcription factor complex KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-8309.35953 BF_2 1254.24 8.83 6232 270012501 EFA08949.1 830 2.3e-85 hypothetical protein TcasGA2_TC006656 [Tribolium castaneum] 642933042 XM_966204.3 206 8.67795e-101 PREDICTED: Tribolium castaneum neo-calmodulin-like (LOC659938), transcript variant X3, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02595 566 3.9e-56 Calmodulin OS=Patinopecten sp. PE=1 SV=2 PF13405//PF10591//PF13833//PF13499//PF12763//PF03874//PF08785//PF00036//PF13202 EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//RNA polymerase Rpb4//Ku C terminal domain like//EF hand//EF hand GO:0006351//GO:0007165//GO:0006144//GO:0006206 transcription, DNA-templated//signal transduction//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0005515//GO:0005509//GO:0016817 DNA-directed RNA polymerase activity//protein binding//calcium ion binding//hydrolase activity, acting on acid anhydrides GO:0005578//GO:0005730 proteinaceous extracellular matrix//nucleolus KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.35954 BF_2 28573.74 1350.88 1172 91084833 XP_966469.1 1262 3.5e-136 PREDICTED: inositol oxygenase [Tribolium castaneum]>gi|270008967|gb|EFA05415.1| hypothetical protein TcasGA2_TC015591 [Tribolium castaneum] -- -- -- -- -- K00469 MIOX inositol oxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00469 Q4V8T0 885 7.5e-94 Inositol oxygenase OS=Danio rerio GN=miox PE=2 SV=1 PF16622//PF01075//PF05153 zinc-finger C2H2-type//Glycosyltransferase family 9 (heptosyltransferase)//Myo-inositol oxygenase GO:0008152//GO:0019310//GO:0055114 metabolic process//inositol catabolic process//oxidation-reduction process GO:0016757//GO:0050113//GO:0046872//GO:0005506 transferase activity, transferring glycosyl groups//inositol oxygenase activity//metal ion binding//iron ion binding GO:0005737 cytoplasm KOG1573 Aldehyde reductase Cluster-8309.35956 BF_2 49.00 1.96 1331 546685810 ERL95253.1 832 2.9e-86 hypothetical protein D910_12520 [Dendroctonus ponderosae] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q3KQG9 576 5.8e-58 Testicular acid phosphatase homolog OS=Xenopus laevis GN=acpt PE=2 SV=1 PF00328//PF00659 Histidine phosphatase superfamily (branch 2)//POLO box duplicated region GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515 acid phosphatase activity//protein binding -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.35957 BF_2 23221.05 427.95 2557 91090780 XP_966783.1 2496 6.2e-279 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [Tribolium castaneum]>gi|642935900|ref|XP_008198220.1| PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [Tribolium castaneum]>gi|642935902|ref|XP_008198221.1| PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X1 [Tribolium castaneum] 170066649 XM_001868153.1 669 0 Culex quinquefasciatus calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2387 1.1e-267 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.35961 BF_2 7276.98 199.90 1810 91094775 XP_968026.1 520 5.9e-50 PREDICTED: cyclin-G2 [Tribolium castaneum]>gi|270016570|gb|EFA13016.1| hypothetical protein TcasGA2_TC001982 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9I1 145 7.4e-08 Cyclin-G1 OS=Bos taurus GN=CCNG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.35962 BF_2 26.65 0.62 2075 332373698 AEE61990.1 1569 1.6e-171 unknown [Dendroctonus ponderosae] 665399649 NM_165636.2 147 1.7947e-68 Drosophila melanogaster phosphoglucose isomerase (Pgi), transcript variant C, mRNA K01810 GPI, pgi glucose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01810 P52031 1358 1.9e-148 Glucose-6-phosphate isomerase OS=Drosophila yakuba GN=Pgi PE=3 SV=1 PF00342//PF02792 Phosphoglucose isomerase//Mago nashi protein GO:0005985//GO:0006094//GO:0006096//GO:0005982//GO:0006098 sucrose metabolic process//gluconeogenesis//glycolytic process//starch metabolic process//pentose-phosphate shunt GO:0004347 glucose-6-phosphate isomerase activity GO:0005634 nucleus KOG2446 Glucose-6-phosphate isomerase Cluster-8309.35963 BF_2 27502.00 1245.32 1211 283046836 NP_001164361.1 1692 5.0e-186 ATP synthase subunit beta, mitochondrial [Tribolium castaneum]>gi|270009266|gb|EFA05714.1| hypothetical protein TcasGA2_TC015322 [Tribolium castaneum] 332375359 BT127859.1 593 0 Dendroctonus ponderosae clone DPO123_G12 unknown mRNA K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q05825 1552 3.5e-171 ATP synthase subunit beta, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-beta PE=1 SV=3 PF00006//PF01637//PF03193//PF00005//PF00931//PF02874 ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//NB-ARC domain//ATP synthase alpha/beta family, beta-barrel domain GO:0015991//GO:0046034//GO:0006119//GO:0015992//GO:0015986 ATP hydrolysis coupled proton transport//ATP metabolic process//oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003924//GO:0043531//GO:0005524//GO:0008553//GO:0046933//GO:0016887//GO:0005525 GTPase activity//ADP binding//ATP binding//hydrogen-exporting ATPase activity, phosphorylative mechanism//proton-transporting ATP synthase activity, rotational mechanism//ATPase activity//GTP binding GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1350 F0F1-type ATP synthase, beta subunit Cluster-8309.35965 BF_2 1006.50 8.30 5363 642930795 XP_008196094.1 4761 0.0e+00 PREDICTED: tight junction protein ZO-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 Q9UDY2 891 6.9e-94 Tight junction protein ZO-2 OS=Homo sapiens GN=TJP2 PE=1 SV=2 PF00018//PF00595//PF13180 SH3 domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3580 Tight junction proteins Cluster-8309.35966 BF_2 947.75 7.89 5312 642924642 XP_008194376.1 4558 0.0e+00 PREDICTED: tensin isoform X2 [Tribolium castaneum] 642924641 XM_008196154.1 194 3.46237e-94 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X2, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 818 2.0e-85 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.35967 BF_2 52.12 0.37 6223 546683575 ERL93373.1 1490 6.8e-162 hypothetical protein D910_10665 [Dendroctonus ponderosae] 642921542 XM_970634.3 217 6.6515e-107 PREDICTED: Tribolium castaneum uncharacterized LOC655573 (LOC655573), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35968 BF_2 19694.94 150.02 5779 570341960 AHE77377.1 2740 7.1e-307 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 905 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2669 5.0e-300 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF01223//PF06723//PF04625//PF00033//PF01194//PF02491//PF01370//PF01968//PF02782//PF08303//PF00106//PF01073//PF05739 DNA/RNA non-specific endonuclease//MreB/Mbl protein//DEC-1 protein, N-terminal region//Cytochrome b/b6/petB//RNA polymerases N / 8 kDa subunit//SHS2 domain inserted in FTSA//NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase//FGGY family of carbohydrate kinases, C-terminal domain//tRNA ligase kinase domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//SNARE domain GO:0008210//GO:0008152//GO:0006388//GO:0022904//GO:0005975//GO:0055114//GO:0000902//GO:0008207//GO:0006144//GO:0006351//GO:0006206//GO:0007049//GO:0007304//GO:0006694//GO:0008209 estrogen metabolic process//metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//carbohydrate metabolic process//oxidation-reduction process//cell morphogenesis//C21-steroid hormone metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//cell cycle//chorion-containing eggshell formation//steroid biosynthetic process//androgen metabolic process GO:0016491//GO:0046872//GO:0003676//GO:0016773//GO:0016616//GO:0003854//GO:0005524//GO:0005515//GO:0003677//GO:0003824//GO:0003972//GO:0016787//GO:0003899//GO:0050662//GO:0005213 oxidoreductase activity//metal ion binding//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//protein binding//DNA binding//catalytic activity//RNA ligase (ATP) activity//hydrolase activity//DNA-directed RNA polymerase activity//coenzyme binding//structural constituent of chorion GO:0005730//GO:0016020//GO:0005576//GO:0042600 nucleolus//membrane//extracellular region//chorion KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.35970 BF_2 3148.24 67.30 2244 8648961 CAB94834.1 2279 7.9e-254 eukaryotic translation initiation factor 2 gamma [Leptinotarsa decemlineata] 8648960 AJ290964.1 484 0 Leptinotarsa decemlineata mRNA for eukaryotic translation initiation factor 2 gamma (eIF-2g gene) K03242 EIF2S3 translation initiation factor 2 subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03242 Q5ZMS3 2027 5.4e-226 Eukaryotic translation initiation factor 2 subunit 3 OS=Gallus gallus GN=EIF2S3 PE=1 SV=1 PF03193//PF03144//PF01926 Protein of unknown function, DUF258//Elongation factor Tu domain 2//50S ribosome-binding GTPase -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0466 Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase) Cluster-8309.35972 BF_2 41531.06 341.67 5372 699049757 AIU39233.1 850 9.5e-88 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 669 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 793 1.6e-82 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF10186//PF16326//PF04111//PF06009//PF00435//PF03577//PF02601//PF08702//PF01105//PF07926//PF10473//PF06160//PF05739 Vacuolar sorting 38 and autophagy-related subunit 14//ABC transporter C-terminal domain//Autophagy protein Apg6//Laminin Domain II//Spectrin repeat//Peptidase family C69//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//SNARE domain GO:0000921//GO:0006308//GO:0006508//GO:0030168//GO:0007155//GO:0006810//GO:0006914//GO:0051258//GO:0007165//GO:0010508//GO:0006606 septin ring assembly//DNA catabolic process//proteolysis//platelet activation//cell adhesion//transport//autophagy//protein polymerization//signal transduction//positive regulation of autophagy//protein import into nucleus GO:0005515//GO:0008855//GO:0003677//GO:0030674//GO:0042803//GO:0045502//GO:0008134//GO:0016805//GO:0005102 protein binding//exodeoxyribonuclease VII activity//DNA binding//protein binding, bridging//protein homodimerization activity//dynein binding//transcription factor binding//dipeptidase activity//receptor binding GO:0005667//GO:0030286//GO:0005940//GO:0016021//GO:0005577//GO:0009318 transcription factor complex//dynein complex//septin ring//integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.35974 BF_2 1060.77 27.93 1876 642912447 XP_008200864.1 229 3.4e-16 PREDICTED: LOW QUALITY PROTEIN: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35975 BF_2 1057.11 14.80 3275 546682278 ERL92239.1 2238 6.6e-249 hypothetical protein D910_09556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 245 3.4e-19 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF00452 Apoptosis regulator proteins, Bcl-2 family GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.35976 BF_2 114.23 0.43 11332 817056547 XP_012269142.1 2226 5.6e-247 PREDICTED: uncharacterized protein LOC105693657 isoform X7 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q9BX66 423 2.7e-39 Sorbin and SH3 domain-containing protein 1 OS=Homo sapiens GN=SORBS1 PE=1 SV=3 PF12549//PF13180//PF14604//PF00383//PF00595//PF00018 Tyrosine hydroxylase N terminal//PDZ domain//Variant SH3 domain//Cytidine and deoxycytidylate deaminase zinc-binding region//PDZ domain (Also known as DHR or GLGF)//SH3 domain GO:0006570//GO:0055114 tyrosine metabolic process//oxidation-reduction process GO:0004511//GO:0008270//GO:0005515 tyrosine 3-monooxygenase activity//zinc ion binding//protein binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.35978 BF_2 2240.00 13.25 7359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35979 BF_2 1404.91 15.59 4058 642935930 XP_008198233.1 4627 0.0e+00 PREDICTED: RRP12-like protein [Tribolium castaneum] 462473101 APGK01001802.1 98 6.13221e-41 Dendroctonus ponderosae Seq01001802, whole genome shotgun sequence K14794 RRP12 ribosomal RNA-processing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14794 Q5ZKD5 1918 4.3e-213 RRP12-like protein OS=Gallus gallus GN=RRP12 PE=2 SV=1 PF16782//PF01113//PF00552 Nucleotide exchange factor SIL1//Dihydrodipicolinate reductase, N-terminus//Integrase DNA binding domain GO:0055114//GO:0009085//GO:0009089 oxidation-reduction process//lysine biosynthetic process//lysine biosynthetic process via diaminopimelate GO:0008839//GO:0000774//GO:0003676 4-hydroxy-tetrahydrodipicolinate reductase//adenyl-nucleotide exchange factor activity//nucleic acid binding GO:0005783 endoplasmic reticulum KOG1248 Uncharacterized conserved protein Cluster-8309.35980 BF_2 486.57 3.32 6419 478263045 ENN81445.1 762 1.8e-77 hypothetical protein YQE_02138, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A6QPN6 236 7.4e-18 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.35981 BF_2 7299.43 52.22 6135 478263045 ENN81445.1 762 1.7e-77 hypothetical protein YQE_02138, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A6QPN6 236 7.1e-18 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.35982 BF_2 180.88 2.56 3238 642910245 XP_008198545.1 635 4.9e-63 PREDICTED: protein pygopus isoform X2 [Tribolium castaneum] 241695262 XM_002412985.1 132 6.13904e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 437 1.8e-41 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF17123//PF00628//PF02121//PF00075//PF13639 RING-like zinc finger//PHD-finger//Phosphatidylinositol transfer protein//RNase H//Ring finger domain GO:0006810//GO:0051252 transport//regulation of RNA metabolic process GO:0008270//GO:0003676//GO:0004523//GO:0005515 zinc ion binding//nucleic acid binding//RNA-DNA hybrid ribonuclease activity//protein binding GO:0005622 intracellular -- -- Cluster-8309.35983 BF_2 100.91 0.88 5081 270005127 EFA01575.1 1872 2.8e-206 hypothetical protein TcasGA2_TC007136 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1544 1.2e-169 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00096//PF03119//PF00643//PF00412 Zinc finger, C2H2 type//NAD-dependent DNA ligase C4 zinc finger domain//B-box zinc finger//LIM domain GO:0006260//GO:0006281 DNA replication//DNA repair GO:0008270//GO:0003911//GO:0046872 zinc ion binding//DNA ligase (NAD+) activity//metal ion binding GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.35984 BF_2 2446.57 32.04 3481 678336953 CDW75723.1 506 4.8e-48 UNKNOWN [Stylonychia lemnae] 375005309 JN619131.1 1870 0 Pogonocherus hispidulus voucher BMNH:835571 18S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35985 BF_2 301.00 13.92 1192 642923500 XP_008193535.1 419 2.0e-38 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.35987 BF_2 143.52 0.33 18725 612342210 AHW99830.1 19163 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1380 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 16243 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF01365//PF00622//PF13499//PF13833//PF02815//PF00520//PF06459//PF00487//PF06423 RIH domain//SPRY domain//EF-hand domain pair//EF-hand domain pair//MIR domain//Ion transport protein//Ryanodine Receptor TM 4-6//Fatty acid desaturase//GWT1 GO:0006816//GO:0055085//GO:0070588//GO:0006874//GO:0006629//GO:0006506//GO:0006811 calcium ion transport//transmembrane transport//calcium ion transmembrane transport//cellular calcium ion homeostasis//lipid metabolic process//GPI anchor biosynthetic process//ion transport GO:0005216//GO:0005262//GO:0005515//GO:0005219//GO:0016746//GO:0005509 ion channel activity//calcium channel activity//protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium ion binding GO:0016021//GO:0005622//GO:0005789//GO:0016020 integral component of membrane//intracellular//endoplasmic reticulum membrane//membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.35988 BF_2 116.36 2.05 2665 478257738 ENN77881.1 468 9.3e-44 hypothetical protein YQE_05559, partial [Dendroctonus ponderosae]>gi|546677678|gb|ERL88472.1| hypothetical protein D910_05858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7E3W5 255 1.9e-20 Synaptogyrin-2 OS=Bos taurus GN=SYNGR2 PE=2 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.35989 BF_2 525.16 9.47 2606 642916614 XP_008191899.1 1314 7.3e-142 PREDICTED: LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [Tribolium castaneum] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 3.2e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.3599 BF_2 11.66 0.52 1227 642911268 XP_972818.2 829 5.9e-86 PREDICTED: NAD-dependent protein deacylase [Tribolium castaneum] -- -- -- -- -- K11415 SIRT5, SIR2L5 NAD-dependent deacetylase sirtuin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11415 E9GD30 562 2.2e-56 NAD-dependent protein deacylase OS=Daphnia pulex GN=DAPPUDRAFT_195469 PE=3 SV=1 PF02146 Sir2 family -- -- GO:0070403 NAD+ binding -- -- KOG2683 Sirtuin 4 and related class II sirtuins (SIR2 family) Cluster-8309.35990 BF_2 191.80 2.08 4142 568599608 AHE13799.1 230 5.8e-16 odorant binding protein [Lissorhoptrus oryzophilus] -- -- -- -- -- -- -- -- -- Q27017 173 9.6e-11 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.35991 BF_2 69.02 1.00 3179 546679851 ERL90239.1 1019 1.4e-107 hypothetical protein D910_07592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83548 607 3.5e-61 Vanin-like protein 3 OS=Drosophila melanogaster GN=CG32750 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.35993 BF_2 4457.34 45.05 4426 478260090 ENN79875.1 3508 0.0e+00 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 6.98351e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 3027 0.0e+00 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006094//GO:0006013//GO:0006000//GO:0006096//GO:0006098//GO:0006012 gluconeogenesis//mannose metabolic process//fructose metabolic process//glycolytic process//pentose-phosphate shunt//galactose metabolic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.35995 BF_2 698.99 2.40 12451 270006541 EFA02989.1 7377 0.0e+00 hypothetical protein TcasGA2_TC010408 [Tribolium castaneum] 642922985 XM_008202260.1 727 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase TRIP12 (LOC658915), transcript variant X4, mRNA K10590 TRIP12 E3 ubiquitin-protein ligase TRIP12 http://www.genome.jp/dbget-bin/www_bget?ko:K10590 F1LP64 4376 0.0e+00 E3 ubiquitin-protein ligase TRIP12 OS=Rattus norvegicus GN=Trip12 PE=2 SV=1 PF00515//PF13374//PF13371//PF13414//PF13176//PF12470//PF13181//PF13174//PF00632//PF00514//PF04049 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Suppressor of Fused Gli/Ci N terminal binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//HECT-domain (ubiquitin-transferase)//Armadillo/beta-catenin-like repeat//Anaphase promoting complex subunit 8 / Cdc23 GO:0016567//GO:0030071 protein ubiquitination//regulation of mitotic metaphase/anaphase transition GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0170 E3 ubiquitin protein ligase Cluster-8309.35996 BF_2 3131.64 90.23 1739 189236526 XP_975464.2 2521 5.3e-282 PREDICTED: spondin-1 [Tribolium castaneum]>gi|270005305|gb|EFA01753.1| hypothetical protein TcasGA2_TC007351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 738 1.2e-76 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.35998 BF_2 36718.81 416.40 3976 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF00983//PF01926//PF03144//PF03764 Tymovirus coat protein//50S ribosome-binding GTPase//Elongation factor Tu domain 2//Elongation factor G, domain IV -- -- GO:0005525//GO:0005198 GTP binding//structural molecule activity GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.35999 BF_2 258.32 8.04 1631 332374148 AEE62215.1 1067 2.0e-113 unknown [Dendroctonus ponderosae]>gi|546676817|gb|ERL87763.1| hypothetical protein D910_05152 [Dendroctonus ponderosae] -- -- -- -- -- K17885 MTCH mitochondrial carrier http://www.genome.jp/dbget-bin/www_bget?ko:K17885 Q791V5 591 1.3e-59 Mitochondrial carrier homolog 2 OS=Mus musculus GN=Mtch2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2745 Mitochondrial carrier protein Cluster-8309.36000 BF_2 53.17 1.52 1751 270009420 EFA05868.1 1905 1.4e-210 hypothetical protein TcasGA2_TC008668 [Tribolium castaneum] 642930354 XM_008198140.1 495 0 PREDICTED: Tribolium castaneum protein 4.1 homolog (LOC662229), transcript variant X4, mRNA K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1380 4.5e-151 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36001 BF_2 319.00 10.48 1560 642929259 XP_008195758.1 895 1.7e-93 PREDICTED: translin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62348 616 1.5e-62 Translin OS=Mus musculus GN=Tsn PE=1 SV=1 PF08988//PF01997 Type III secretion system, cytoplasmic E component of needle//Translin family GO:0009405 pathogenesis GO:0043565 sequence-specific DNA binding -- -- KOG3067 Translin family protein Cluster-8309.36002 BF_2 1160.25 21.33 2563 549438519 AGX25148.1 2765 4.0e-310 beta-glucuronidase-like protein [Leptinotarsa decemlineata] 195400569 XM_002058853.1 36 1.12641e-06 Drosophila virilis GJ19669 (Dvir\GJ19669), mRNA K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P08236 1387 1.0e-151 Beta-glucuronidase OS=Homo sapiens GN=GUSB PE=1 SV=2 PF02836//PF00703//PF02837 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.36004 BF_2 60.10 1.15 2482 270001997 EEZ98444.1 975 1.4e-102 hypothetical protein TcasGA2_TC000933 [Tribolium castaneum] 459668605 JX303047.1 36 1.09032e-06 Lutzomyia longipalpis isolate PanupC10 up (up) gene, partial cds >gnl|BL_ORD_ID|16415056 Lutzomyia longipalpis isolate PanupH11 up (up) gene, partial cds K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 Q9XZ71 852 1.1e-89 Troponin T OS=Periplaneta americana GN=TNT PE=2 SV=1 PF00769//PF00992 Ezrin/radixin/moesin family//Troponin -- -- GO:0008092 cytoskeletal protein binding GO:0019898//GO:0005861//GO:0005737 extrinsic component of membrane//troponin complex//cytoplasm KOG3634 Troponin Cluster-8309.36005 BF_2 3497.49 83.14 2047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965//PF15048 dsRNA-gated channel SID-1//Organic solute transporter subunit beta protein GO:0033227//GO:0015931//GO:0006810//GO:0015721 dsRNA transport//nucleobase-containing compound transport//transport//bile acid and bile salt transport GO:0051033//GO:0046982//GO:0005215 RNA transmembrane transporter activity//protein heterodimerization activity//transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.36006 BF_2 329.57 20.99 944 642936964 XP_008198631.1 1380 5.8e-150 PREDICTED: rab GTPase-activating protein 1-like isoform X2 [Tribolium castaneum]>gi|270001031|gb|EEZ97478.1| hypothetical protein TcasGA2_TC011312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 870 3.3e-92 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 -- -- -- -- -- -- GO:0005622 intracellular KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.36007 BF_2 33.68 0.91 1827 33112583 AAP94047.1 1363 1.1e-147 cathepsin-L-like cysteine peptidase 03 [Tenebrio molitor] 33112582 AY332271.1 234 6.83386e-117 Tenebrio molitor cathepsin-L-like cysteine peptidase 03 mRNA, complete cds K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1201 2.7e-130 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.36008 BF_2 90.36 0.46 8540 91085895 XP_968071.1 2691 5.1e-301 PREDICTED: nucleolar protein 6 [Tribolium castaneum]>gi|270009966|gb|EFA06414.1| hypothetical protein TcasGA2_TC009293 [Tribolium castaneum] 158524687 EU074287.1 98 1.29602e-40 Alcyonidium diaphanum methionine adenosyltransferase mRNA, partial cds K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 P40320 1680 3.6e-185 S-adenosylmethionine synthase OS=Drosophila melanogaster GN=Sam-S PE=2 SV=2 PF00961//PF02772//PF05864//PF00438//PF00580//PF02773 LAGLIDADG endonuclease//S-adenosylmethionine synthetase, central domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//S-adenosylmethionine synthetase, N-terminal domain//UvrD/REP helicase N-terminal domain//S-adenosylmethionine synthetase, C-terminal domain GO:0006351//GO:0006144//GO:0006206//GO:0006556//GO:0006555 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//S-adenosylmethionine biosynthetic process//methionine metabolic process GO:0003677//GO:0004478//GO:0005524//GO:0003899//GO:0004519 DNA binding//methionine adenosyltransferase activity//ATP binding//DNA-directed RNA polymerase activity//endonuclease activity GO:0005730 nucleolus KOG1506 S-adenosylmethionine synthetase Cluster-8309.36009 BF_2 20.35 5.41 444 530723035 AGT42326.1 598 1.3e-59 cardiac muscle actin [Portunus trituberculatus] 530723034 KC131029.1 258 7.14358e-131 Portunus trituberculatus cardiac muscle actin mRNA, complete cds K12315 ACTG2 actin, gamma-enteric smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12315 P63268 572 5.6e-58 Actin, gamma-enteric smooth muscle OS=Mus musculus GN=Actg2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.36010 BF_2 853.84 4.59 8064 546673207 ERL84861.1 1263 1.8e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.1e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF00503//PF03824//PF01166//PF06005//PF04111//PF06156//PF15458//PF17078//PF04548//PF02183//PF03193//PF00005//PF07989//PF00437//PF01066//PF05529//PF04632 G-protein alpha subunit//High-affinity nickel-transport protein//TSC-22/dip/bun family//Protein of unknown function (DUF904)//Autophagy protein Apg6//Protein of unknown function (DUF972)//Nineteen complex-related protein 2//SWI5-dependent HO expression protein 3//AIG1 family//Homeobox associated leucine zipper//Protein of unknown function, DUF258//ABC transporter//Centrosomin N-terminal motif 1//Type II/IV secretion system protein//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like//Fusaric acid resistance protein family GO:0007165//GO:0006914//GO:0006810//GO:0006886//GO:0006355//GO:0007186//GO:0000390//GO:0015675//GO:0043093//GO:0008654//GO:0000917//GO:0035444//GO:0006260//GO:0051028//GO:0048309 signal transduction//autophagy//transport//intracellular protein transport//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//nickel cation transport//FtsZ-dependent cytokinesis//phospholipid biosynthetic process//barrier septum assembly//nickel cation transmembrane transport//DNA replication//mRNA transport//endoplasmic reticulum inheritance GO:0043565//GO:0016780//GO:0005525//GO:0015099//GO:0004871//GO:0005524//GO:0031683//GO:0003924//GO:0019001//GO:0016887//GO:0003700//GO:0046872 sequence-specific DNA binding//phosphotransferase activity, for other substituted phosphate groups//GTP binding//nickel cation transmembrane transporter activity//signal transducer activity//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//guanyl nucleotide binding//ATPase activity//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0016021//GO:0005815//GO:0005737//GO:0005886//GO:0005783//GO:0016020//GO:0071008//GO:0005667 integral component of membrane//microtubule organizing center//cytoplasm//plasma membrane//endoplasmic reticulum//membrane//U2-type post-mRNA release spliceosomal complex//transcription factor complex KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.36013 BF_2 181.25 1.68 4787 91091728 XP_967315.1 1405 3.7e-152 PREDICTED: argininosuccinate synthase [Tribolium castaneum]>gi|270001069|gb|EEZ97516.1| hypothetical protein TcasGA2_TC011361 [Tribolium castaneum] 78496741 CP000153.1 36 2.11626e-06 Sulfurimonas denitrificans DSM 1251, complete genome K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q0IFL5 1165 1.0e-125 Argininosuccinate synthase OS=Aedes aegypti GN=AAEL004701 PE=3 SV=1 PF00764//PF00498 Arginosuccinate synthase//FHA domain GO:0006522//GO:0006526//GO:0006560//GO:0006531 alanine metabolic process//arginine biosynthetic process//proline metabolic process//aspartate metabolic process GO:0005524//GO:0005515//GO:0004055 ATP binding//protein binding//argininosuccinate synthase activity -- -- KOG1706 Argininosuccinate synthase Cluster-8309.36014 BF_2 62648.29 1698.64 1830 546683575 ERL93373.1 1505 3.6e-164 hypothetical protein D910_10665 [Dendroctonus ponderosae] 642921542 XM_970634.3 225 6.89389e-112 PREDICTED: Tribolium castaneum uncharacterized LOC655573 (LOC655573), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36015 BF_2 14281.39 120.35 5251 557211143 CDJ50285.1 179 6.0e-10 hypothetical protein EBH_0032330 [Eimeria brunetti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00977 Histidine biosynthesis protein GO:0000105 histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.36017 BF_2 43.11 0.80 2553 91081961 XP_966594.1 514 4.2e-49 PREDICTED: Y-box factor homolog isoform X1 [Tribolium castaneum]>gi|270007364|gb|EFA03812.1| hypothetical protein TcasGA2_TC013925 [Tribolium castaneum] 642921886 XM_970820.3 210 2.10819e-103 PREDICTED: Tribolium castaneum Y-box factor homolog (LOC656063), transcript variant X2, mRNA K06099 CSDA, ZONAB cold shock domain protein A http://www.genome.jp/dbget-bin/www_bget?ko:K06099 P41824 393 1.8e-36 Y-box factor homolog OS=Aplysia californica PE=2 SV=1 PF00621//PF00313 RhoGEF domain//'Cold-shock' DNA-binding domain GO:0006355//GO:0043087//GO:0035023 regulation of transcription, DNA-templated//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089//GO:0003677 Rho guanyl-nucleotide exchange factor activity//DNA binding -- -- KOG3070 Predicted RNA-binding protein containing PIN domain and invovled in translation or RNA processing Cluster-8309.36018 BF_2 66.27 0.60 4923 270005127 EFA01575.1 1730 7.9e-190 hypothetical protein TcasGA2_TC007136 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1422 1.7e-155 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF02085//PF00412//PF05495 Class III cytochrome C family//LIM domain//CHY zinc finger GO:0006118 obsolete electron transport GO:0008270//GO:0009055//GO:0020037 zinc ion binding//electron carrier activity//heme binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36019 BF_2 419.69 8.97 2244 91095131 XP_971500.1 1627 3.2e-178 PREDICTED: transforming growth factor-beta-induced protein ig-h3 [Tribolium castaneum]>gi|270015611|gb|EFA12059.1| hypothetical protein TcasGA2_TC012903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15063 425 3.1e-40 Periostin OS=Homo sapiens GN=POSTN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.36020 BF_2 1290.32 15.82 3699 642913015 XP_008201353.1 4683 0.0e+00 PREDICTED: spectrin alpha chain [Tribolium castaneum]>gi|270002786|gb|EEZ99233.1| alpha spectrin [Tribolium castaneum] 158296318 XM_316724.4 961 0 Anopheles gambiae str. PEST AGAP006686-PA (AgaP_AGAP006686) mRNA, complete cds K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 4249 0.0e+00 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36021 BF_2 47.31 0.44 4790 91078972 XP_974414.1 2664 3.8e-298 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1610 2.6e-177 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00927//PF00868 Transglutaminase family, C-terminal ig like domain//Transglutaminase family GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.36022 BF_2 967.01 5.44 7723 642938555 XP_008199840.1 3532 0.0e+00 PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum]>gi|642938557|ref|XP_008199841.1| PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum] 642938563 XM_963618.3 697 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X6, mRNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.3e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF09258//PF01312//PF01602//PF00514 HEAT repeat//Glycosyl transferase family 64 domain//FlhB HrpN YscU SpaS Family//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0015012//GO:0006024//GO:0009306//GO:0016192//GO:0006886 heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process//protein secretion//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0016020//GO:0030117//GO:0016021 membrane//membrane coat//integral component of membrane KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.36024 BF_2 701.71 93.82 600 642915081 XP_008190403.1 488 1.0e-46 PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|642915083|ref|XP_008190404.1| PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|270002357|gb|EEZ98804.1| hypothetical protein TcasGA2_TC001374 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q23808 295 9.9e-26 Aquaporin AQPcic OS=Cicadella viridis GN=AQP PE=1 SV=1 PF00230//PF17070 Major intrinsic protein//30S ribosomal protein Thx GO:0006810 transport GO:0005215 transporter activity GO:0005840//GO:0016020 ribosome//membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.36026 BF_2 48.00 0.92 2467 642929374 XP_008195808.1 778 9.8e-80 PREDICTED: rho GTPase-activating protein 11A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P4F7 259 6.1e-21 Rho GTPase-activating protein 11A OS=Homo sapiens GN=ARHGAP11A PE=1 SV=2 PF11365//PF05445//PF01736//PF00620 Protein of unknown function (DUF3166)//Poxvirus serine/threonine protein kinase//Polyomavirus agnoprotein//RhoGAP domain GO:0010506//GO:0007165 regulation of autophagy//signal transduction GO:0004672//GO:0005524//GO:0003677 protein kinase activity//ATP binding//DNA binding GO:0005615 extracellular space -- -- Cluster-8309.36027 BF_2 10375.81 154.86 3090 91090103 XP_970810.1 1785 2.1e-196 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.1159e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O96647 1088 5.7e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF14634//PF00252//PF13639 zinc-RING finger domain//Ribosomal protein L16p/L10e//Ring finger domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0046872//GO:0008270//GO:0003735 protein binding//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.36028 BF_2 14075.40 696.95 1132 264667425 ACY71298.1 1234 6.0e-133 ribosomal protein L8 [Chrysomela tremula] 401828841 JX122920.1 415 0 Phaedon cochleariae ribosomal protein L8 mRNA, partial cds K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q6RYS3 1160 9.4e-126 60S ribosomal protein L8 OS=Mamestra brassicae GN=RpL8 PE=2 SV=1 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2309 60s ribosomal protein L2/L8 Cluster-8309.36029 BF_2 66.53 0.40 7278 589060792 AHK26789.1 2872 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 2.85901e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2262 9.9e-253 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF05896//PF00682//PF07478//PF02786//PF02655 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//HMGL-like//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//ATP-grasp domain GO:0046436//GO:0055114//GO:0009252//GO:0006814//GO:0006118 D-alanine metabolic process//oxidation-reduction process//peptidoglycan biosynthetic process//sodium ion transport//obsolete electron transport GO:0005524//GO:0003824//GO:0008716//GO:0016655//GO:0046872 ATP binding//catalytic activity//D-alanine-D-alanine ligase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//metal ion binding -- -- KOG0369 Pyruvate carboxylase Cluster-8309.36030 BF_2 1272.12 17.99 3245 91090103 XP_970810.1 1889 1.9e-208 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.17254e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds -- -- -- -- O96647 1088 6.0e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF03854//PF14634//PF00252//PF13639 P-11 zinc finger//zinc-RING finger domain//Ribosomal protein L16p/L10e//Ring finger domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0005515//GO:0008270//GO:0003735//GO:0046872 RNA binding//protein binding//zinc ion binding//structural constituent of ribosome//metal ion binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.36032 BF_2 23.24 0.38 2813 189236215 XP_975776.2 422 2.1e-38 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] -- -- -- -- -- K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 Q00075 181 7.7e-12 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1 OS=Aspergillus niger GN=tpsA PE=3 SV=1 PF00982 Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.36033 BF_2 146.98 14.20 720 642914311 XP_008201630.1 567 8.4e-56 PREDICTED: mimitin, mitochondrial [Tribolium castaneum]>gi|270002195|gb|EEZ98642.1| hypothetical protein TcasGA2_TC001170 [Tribolium castaneum] -- -- -- -- -- K18160 NDUFAF2 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18160 Q32P65 147 1.7e-08 Mimitin, mitochondrial OS=Bos taurus GN=NDUFAF2 PE=2 SV=1 PF01907//PF05071 Ribosomal protein L37e//NADH ubiquinone oxidoreductase subunit NDUFA12 GO:0006412//GO:0006120//GO:0042254//GO:0015992//GO:0006814//GO:0006118//GO:0006744 translation//mitochondrial electron transport, NADH to ubiquinone//ribosome biogenesis//proton transport//sodium ion transport//obsolete electron transport//ubiquinone biosynthetic process GO:0008137//GO:0003735//GO:0009055 NADH dehydrogenase (ubiquinone) activity//structural constituent of ribosome//electron carrier activity GO:0005840//GO:0005622//GO:0016020 ribosome//intracellular//membrane -- -- Cluster-8309.36034 BF_2 30.23 0.79 1894 642922794 XP_008193328.1 508 1.5e-48 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 2.9e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.36035 BF_2 33885.49 556.14 2836 642911248 XP_008199756.1 2946 0.0e+00 PREDICTED: polyadenylate-binding protein 1 isoform X1 [Tribolium castaneum] 642911247 XM_008201534.1 595 0 PREDICTED: Tribolium castaneum polyadenylate-binding protein 1 (LOC657776), transcript variant X1, mRNA K13126 PABPC polyadenylate-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13126 P29341 2137 1.2e-238 Polyadenylate-binding protein 1 OS=Mus musculus GN=Pabpc1 PE=1 SV=2 PF16367//PF00658//PF00076 RNA recognition motif//Poly-adenylate binding protein, unique domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-8309.36036 BF_2 355.46 5.59 2945 270002097 EEZ98544.1 638 2.0e-63 hypothetical protein TcasGA2_TC001048 [Tribolium castaneum] 642913817 XM_008202950.1 224 4.01702e-111 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 450 5.2e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13405//PF12558//PF13499 EF-hand domain//ATP-binding cassette cobalt transporter//EF-hand domain pair -- -- GO:0005509//GO:0016820 calcium ion binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.36037 BF_2 81.96 0.81 4508 270011248 EFA07696.1 495 1.2e-46 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI85 213 2.4e-15 Smoothelin-like protein 2 OS=Bos taurus GN=SMTNL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.36038 BF_2 3415.53 138.47 1319 91088775 XP_967272.1 1008 1.1e-106 PREDICTED: peptide methionine sulfoxide reductase [Tribolium castaneum]>gi|270011632|gb|EFA08080.1| hypothetical protein TcasGA2_TC005676 [Tribolium castaneum] -- -- -- -- -- K07304 msrA peptide-methionine (S)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07304 P08761 637 4.8e-65 Peptide methionine sulfoxide reductase OS=Drosophila melanogaster GN=Eip71CD PE=2 SV=2 PF01625 Peptide methionine sulfoxide reductase GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0008113 peptide-methionine (S)-S-oxide reductase activity -- -- KOG1635 Peptide methionine sulfoxide reductase Cluster-8309.36039 BF_2 205.20 5.16 1952 91085253 XP_973335.1 1079 9.7e-115 PREDICTED: uncharacterized protein LOC662125 [Tribolium castaneum]>gi|270009097|gb|EFA05545.1| hypothetical protein TcasGA2_TC015733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006605//GO:0006886 protein targeting//intracellular protein transport -- -- GO:0016020 membrane -- -- Cluster-8309.36042 BF_2 450.00 15.29 1518 91079502 XP_969250.1 864 6.4e-90 PREDICTED: uncharacterized protein LOC657715 isoform X1 [Tribolium castaneum]>gi|270004422|gb|EFA00870.1| hypothetical protein TcasGA2_TC003773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KY0 126 1.0e-05 Apolipoprotein D OS=Bos taurus GN=APOD PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36044 BF_2 541.23 8.30 3014 820805526 AKG92754.1 921 3.1e-96 usf [Leptinotarsa decemlineata] 820805525 KP147917.1 174 2.56408e-83 Leptinotarsa decemlineata usf mRNA, complete cds K12191 CHMP2A charged multivesicular body protein 2A http://www.genome.jp/dbget-bin/www_bget?ko:K12191 Q6DFS6 458 6.3e-44 Charged multivesicular body protein 2a OS=Xenopus tropicalis GN=chmp2a PE=2 SV=1 PF06156//PF05615//PF01346//PF06729//PF03357//PF00010//PF05848//PF04152//PF04420 Protein of unknown function (DUF972)//Tho complex subunit 7//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Kinetochore component, CENP-R//Snf7//Helix-loop-helix DNA-binding domain//Firmicute transcriptional repressor of class III stress genes (CtsR)//Mre11 DNA-binding presumed domain//CHD5-like protein GO:0006950//GO:0006397//GO:0006457//GO:0034080//GO:0071816//GO:0006355//GO:0006260//GO:0007034//GO:0006302 response to stress//mRNA processing//protein folding//CENP-A containing nucleosome assembly//tail-anchored membrane protein insertion into ER membrane//regulation of transcription, DNA-templated//DNA replication//vacuolar transport//double-strand break repair GO:0004519//GO:0003677//GO:0046983//GO:0030145 endonuclease activity//DNA binding//protein dimerization activity//manganese ion binding GO:0005634//GO:0000445 nucleus//THO complex part of transcription export complex KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.36047 BF_2 2691.05 103.77 1372 270013371 EFA09819.1 970 3.0e-102 hypothetical protein TcasGA2_TC011965 [Tribolium castaneum] 780158183 XM_011684374.1 51 2.73274e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 Q9VJE5 554 2.1e-55 Restin homolog OS=Drosophila melanogaster GN=CLIP-190 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36048 BF_2 603.63 15.69 1897 642913235 XP_008201450.1 758 1.6e-77 PREDICTED: uncharacterized protein LOC664170 isoform X3 [Tribolium castaneum] 642913234 XM_008203228.1 83 6.19077e-33 PREDICTED: Tribolium castaneum uncharacterized LOC664170 (LOC664170), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36049 BF_2 1204.93 10.69 5002 642935312 XP_008197963.1 2029 1.7e-224 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.0147e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1109 3.4e-119 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF10186//PF00038//PF08702 Vacuolar sorting 38 and autophagy-related subunit 14//Intermediate filament protein//Fibrinogen alpha/beta chain family GO:0051258//GO:0007165//GO:0010508//GO:0030168 protein polymerization//signal transduction//positive regulation of autophagy//platelet activation GO:0005198//GO:0030674//GO:0005102 structural molecule activity//protein binding, bridging//receptor binding GO:0005882//GO:0005577 intermediate filament//fibrinogen complex -- -- Cluster-8309.36050 BF_2 32.22 0.31 4619 642935312 XP_008197963.1 2170 7.1e-241 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 9.36442e-15 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1138 1.4e-122 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF10186//PF00038//PF08702 Vacuolar sorting 38 and autophagy-related subunit 14//Intermediate filament protein//Fibrinogen alpha/beta chain family GO:0030168//GO:0010508//GO:0007165//GO:0051258 platelet activation//positive regulation of autophagy//signal transduction//protein polymerization GO:0030674//GO:0005102//GO:0005198 protein binding, bridging//receptor binding//structural molecule activity GO:0005577//GO:0005882 fibrinogen complex//intermediate filament -- -- Cluster-8309.36051 BF_2 124.92 63.13 367 329762924 AEC04843.1 355 1.6e-31 chemosensory protein [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q9W1C9 292 1.4e-25 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF00649//PF02664 Copper fist DNA binding domain//S-Ribosylhomocysteinase (LuxS) GO:0006355//GO:0009372 regulation of transcription, DNA-templated//quorum sensing GO:0005506//GO:0003700//GO:0003677//GO:0005507//GO:0043768 iron ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding//copper ion binding//S-ribosylhomocysteine lyase activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36052 BF_2 558.60 6.31 3989 91090196 XP_967193.1 2643 8.7e-296 PREDICTED: cyclin-G-associated kinase [Tribolium castaneum]>gi|270013468|gb|EFA09916.1| hypothetical protein TcasGA2_TC012067 [Tribolium castaneum] -- -- -- -- -- K08855 GAK cyclin G-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08855 P97874 1662 2.0e-183 Cyclin-G-associated kinase OS=Rattus norvegicus GN=Gak PE=2 SV=1 PF00782//PF07714//PF00069 Dual specificity phosphatase, catalytic domain//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0006470//GO:0016310 protein phosphorylation//protein dephosphorylation//phosphorylation GO:0008138//GO:0004672//GO:0000166//GO:0005524 protein tyrosine/serine/threonine phosphatase activity//protein kinase activity//nucleotide binding//ATP binding -- -- KOG1989 ARK protein kinase family Cluster-8309.36053 BF_2 6962.04 41.95 7230 642917231 XP_008191173.1 2074 1.5e-229 PREDICTED: thioredoxin reductase 2, mitochondrial isoform X2 [Tribolium castaneum] 195396538 XM_002056853.1 42 1.47971e-09 Drosophila virilis GJ16646 (Dvir\GJ16646), mRNA K00384 trxB thioredoxin reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00384 P91938 1574 5.9e-173 Thioredoxin reductase 1, mitochondrial OS=Drosophila melanogaster GN=Trxr-1 PE=1 SV=2 PF01296//PF02852//PF07992//PF01494//PF00106//PF12831//PF05699//PF01979//PF03435//PF01266//PF06268//PF00070//PF04369//PF02558//PF01134 Galanin//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//short chain dehydrogenase//FAD dependent oxidoreductase//hAT family C-terminal dimerisation region//Amidohydrolase family//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Fascin domain//Pyridine nucleotide-disulphide oxidoreductase//Lactococcin-like family//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A GO:0008152//GO:0045454//GO:0007165//GO:0015940//GO:0042742//GO:0055114//GO:0008033 metabolic process//cell redox homeostasis//signal transduction//pantothenate biosynthetic process//defense response to bacterium//oxidation-reduction process//tRNA processing GO:0005179//GO:0046983//GO:0016491//GO:0030674//GO:0050660//GO:0008677//GO:0016787//GO:0071949//GO:0051015 hormone activity//protein dimerization activity//oxidoreductase activity//protein binding, bridging//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//hydrolase activity//FAD binding//actin filament binding GO:0005576 extracellular region KOG4716 Thioredoxin reductase Cluster-8309.36054 BF_2 1880.00 89.08 1170 546675310 ERL86538.1 247 1.7e-18 hypothetical protein D910_03944 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36055 BF_2 273.88 7.26 1865 189237846 XP_974719.2 2264 3.6e-252 PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|642924610|ref|XP_008194362.1| PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|270007960|gb|EFA04408.1| hypothetical protein TcasGA2_TC014707 [Tribolium castaneum] 642924609 XM_008196140.1 369 0 PREDICTED: Tribolium castaneum BTB/POZ domain-containing protein 6 (LOC663586), transcript variant X2, mRNA -- -- -- -- F7ASZ0 357 2.0e-32 BTB/POZ domain-containing protein 3 OS=Callithrix jacchus GN=BTBD3 PE=2 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.36056 BF_2 55.79 1.08 2443 270001997 EEZ98444.1 975 1.4e-102 hypothetical protein TcasGA2_TC000933 [Tribolium castaneum] 459668605 JX303047.1 36 1.07295e-06 Lutzomyia longipalpis isolate PanupC10 up (up) gene, partial cds >gnl|BL_ORD_ID|16415056 Lutzomyia longipalpis isolate PanupH11 up (up) gene, partial cds K12046 TNNT3 troponin T, fast skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12046 Q9XZ71 852 1.0e-89 Troponin T OS=Periplaneta americana GN=TNT PE=2 SV=1 PF00769//PF00992 Ezrin/radixin/moesin family//Troponin -- -- GO:0008092 cytoskeletal protein binding GO:0005737//GO:0005861//GO:0019898 cytoplasm//troponin complex//extrinsic component of membrane KOG3634 Troponin Cluster-8309.36057 BF_2 3405.02 101.54 1690 642929787 XP_008195976.1 644 2.3e-64 PREDICTED: elongation of very long chain fatty acids protein AAEL008004-like [Tribolium castaneum]>gi|270009529|gb|EFA05977.1| hypothetical protein TcasGA2_TC008803 [Tribolium castaneum] -- -- -- -- -- K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 Q1HRV8 475 3.8e-46 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36058 BF_2 43.66 0.72 2826 332375592 AEE62937.1 1501 1.6e-163 unknown [Dendroctonus ponderosae]>gi|478256607|gb|ENN76789.1| hypothetical protein YQE_06630, partial [Dendroctonus ponderosae]>gi|546685197|gb|ERL94724.1| hypothetical protein D910_11998 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.36059 BF_2 1844.76 47.79 1902 91077370 XP_975175.1 898 9.2e-94 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001655|gb|EEZ98102.1| hypothetical protein TcasGA2_TC000515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28493 580 2.8e-58 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3606 BF_2 5.00 0.39 822 565318441 ETE69712.1 750 5.7e-77 Transcription factor BTF3, partial [Ophiophagus hannah] 83641883 NM_001207.4 822 0 Homo sapiens basic transcription factor 3 (BTF3), transcript variant 2, mRNA K01527 EGD1, BTF3 nascent polypeptide-associated complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01527 Q64152 739 4.5e-77 Transcription factor BTF3 OS=Mus musculus GN=Btf3 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2240 RNA polymerase II general transcription factor BTF3 and related proteins Cluster-8309.36060 BF_2 307.42 4.69 3028 282165790 NP_001164134.1 941 1.5e-98 drongo protein isoform 1 [Tribolium castaneum] -- -- -- -- -- K15044 AGFG1 Arf-GAP domain and FG repeats-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15044 P52594 415 6.1e-39 Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens GN=AGFG1 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0702 Predicted GTPase-activating protein Cluster-8309.36061 BF_2 72.00 7.87 670 642929699 XP_008195940.1 522 1.3e-50 PREDICTED: 28S ribosomal protein S18a, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02963 RP-S18, MRPS18, rpsR small subunit ribosomal protein S18 http://www.genome.jp/dbget-bin/www_bget?ko:K02963 Q9NVS2 176 7.0e-12 28S ribosomal protein S18a, mitochondrial OS=Homo sapiens GN=MRPS18A PE=1 SV=1 PF01084 Ribosomal protein S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3162 Mitochondrial/chloroplast ribosomal protein S18 Cluster-8309.36062 BF_2 2407.56 23.11 4645 478256677 ENN76859.1 1576 5.4e-172 hypothetical protein YQE_06700, partial [Dendroctonus ponderosae]>gi|546685126|gb|ERL94653.1| hypothetical protein D910_11928 [Dendroctonus ponderosae] 642911030 XM_008195294.1 438 0 PREDICTED: Tribolium castaneum probable RNA-binding protein orb2 (LOC657803), mRNA K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 Q9VSR3 1363 1.1e-148 Probable RNA-binding protein orb2 OS=Drosophila melanogaster GN=orb2 PE=1 SV=1 PF00076//PF16367//PF00643 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//B-box zinc finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular KOG0129 Predicted RNA-binding protein (RRM superfamily) Cluster-8309.36063 BF_2 165.06 0.60 11887 546673612 ERL85176.1 14419 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911110 XM_008202361.1 2796 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 6543 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF16794//PF15170//PF01891//PF01108//PF16656//PF01300//PF00041//PF13895 Fibronectin-III type domain//Calcium/calmodulin-dependent protein kinase II inhibitor//Cobalt uptake substrate-specific transmembrane region//Tissue factor//Purple acid Phosphatase, N-terminal domain//Telomere recombination//Fibronectin type III domain//Immunoglobulin domain GO:0045859//GO:0019497//GO:0000041//GO:0006771 regulation of protein kinase activity//hexachlorocyclohexane metabolic process//transition metal ion transport//riboflavin metabolic process GO:0005515//GO:0004860//GO:0003725//GO:0046872//GO:0003993 protein binding//protein kinase inhibitor activity//double-stranded RNA binding//metal ion binding//acid phosphatase activity GO:0016021 integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36065 BF_2 179.37 7.71 1260 642938917 XP_001808877.2 711 2.9e-72 PREDICTED: suppressor protein SRP40-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03884 Domain of unknown function (DUF329) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36066 BF_2 281.57 8.82 1623 270007710 EFA04158.1 1449 1.0e-157 hypothetical protein TcasGA2_TC014404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82198 212 1.1e-15 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus GN=Tgfbi PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36067 BF_2 713.57 12.14 2745 642925622 XP_008194644.1 2385 5.0e-266 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 1 [Tribolium castaneum]>gi|270008661|gb|EFA05109.1| hypothetical protein TcasGA2_TC015209 [Tribolium castaneum] 642925621 XM_008196422.1 311 1.62157e-159 PREDICTED: Tribolium castaneum polypeptide N-acetylgalactosaminyltransferase 1 (LOC662156), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV20 1326 1.3e-144 Polypeptide N-acetylgalactosaminyltransferase 1 OS=Drosophila melanogaster GN=GalNAc-T1 PE=2 SV=2 PF12300 Protein of unknown function (DUF3628) GO:0006486 protein glycosylation GO:0016757//GO:0016817 transferase activity, transferring glycosyl groups//hydrolase activity, acting on acid anhydrides GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.36068 BF_2 39995.00 3856.39 721 478263038 ENN81438.1 629 5.4e-63 hypothetical protein YQE_02131, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q25490 155 2.0e-09 Apolipophorins OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36069 BF_2 155.43 0.91 7469 270011103 EFA07551.1 3565 0.0e+00 semaphorin-1a-like protein [Tribolium castaneum] 642930289 XM_008198109.1 776 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2582 8.0e-290 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF01403//PF01437//PF05700 Sema domain//Plexin repeat//Breast carcinoma amplified sequence 2 (BCAS2) GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.36071 BF_2 56.58 0.65 3931 546670831 ERL83427.1 3538 0.0e+00 hypothetical protein D910_00401 [Dendroctonus ponderosae] 242021484 XM_002431130.1 400 0 Pediculus humanus corporis protein transport protein Sec23A, putative, mRNA K14006 SEC23 protein transport protein SEC23 http://www.genome.jp/dbget-bin/www_bget?ko:K14006 A2VDL8 3038 0.0e+00 Protein transport protein Sec23A OS=Bos taurus GN=SEC23A PE=2 SV=1 PF04815//PF04811//PF04810 Sec23/Sec24 helical domain//Sec23/Sec24 trunk domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270 zinc ion binding GO:0030127 COPII vesicle coat KOG1986 Vesicle coat complex COPII, subunit SEC23 Cluster-8309.36073 BF_2 2411.00 77.89 1582 642912900 XP_008201300.1 156 8.4e-08 PREDICTED: uncharacterized protein LOC660583 [Tribolium castaneum]>gi|270001890|gb|EEZ98337.1| hypothetical protein TcasGA2_TC000791 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36074 BF_2 268.13 5.81 2217 546678005 ERL88729.1 1301 2.0e-140 hypothetical protein D910_06111 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BNA9 1005 1.7e-107 CCR4-NOT transcription complex subunit 11 OS=Rattus norvegicus GN=Cnot11 PE=2 SV=1 PF00451//PF03823 Scorpion short toxin, BmKK2//Neurokinin B GO:0006810//GO:0007217//GO:0009405 transport//tachykinin receptor signaling pathway//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.36075 BF_2 71.98 0.80 4036 642936487 XP_008198457.1 1515 5.5e-165 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.95391e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence -- -- -- -- Q60934 793 1.2e-82 Glutamate receptor ionotropic, kainate 1 OS=Mus musculus GN=Grik1 PE=2 SV=2 PF05699//PF00060//PF10613//PF01699 hAT family C-terminal dimerisation region//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//Sodium/calcium exchanger protein GO:0006811//GO:0055085//GO:0007165//GO:0007268 ion transport//transmembrane transport//signal transduction//synaptic transmission GO:0005216//GO:0005234//GO:0004970//GO:0046983 ion channel activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//protein dimerization activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.36078 BF_2 754.23 3.56 9151 332374194 AEE62238.1 2095 7.0e-232 unknown [Dendroctonus ponderosae]>gi|478254520|gb|ENN74766.1| hypothetical protein YQE_08654, partial [Dendroctonus ponderosae] 332374193 BT127276.1 565 0 Dendroctonus ponderosae clone DPO011_E07 unknown mRNA -- -- -- -- P61022 645 4.0e-65 Calcineurin B homologous protein 1 OS=Mus musculus GN=Chp1 PE=1 SV=2 PF01522//PF12763//PF13499//PF00963//PF10591//PF13833//PF13405//PF13202//PF00036 Polysaccharide deacetylase//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Cohesin domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand//EF hand GO:0007165//GO:0000272//GO:0005975//GO:0006807 signal transduction//polysaccharide catabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0005515//GO:0030246//GO:0005509//GO:0016810 protein binding//carbohydrate binding//calcium ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0005578 proteinaceous extracellular matrix KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.36079 BF_2 251.00 115.20 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36080 BF_2 355.57 8.85 1968 91089747 XP_975172.1 1664 1.4e-182 PREDICTED: bifunctional coenzyme A synthase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K02318 COASY phosphopantetheine adenylyltransferase / dephospho-CoA kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02318 Q8MIR4 807 1.4e-84 Bifunctional coenzyme A synthase OS=Sus scrofa GN=COASY PE=1 SV=1 PF01467//PF01121 Cytidylyltransferase-like//Dephospho-CoA kinase GO:0015937//GO:0009058//GO:0015940 coenzyme A biosynthetic process//biosynthetic process//pantothenate biosynthetic process GO:0004140//GO:0005524//GO:0003824 dephospho-CoA kinase activity//ATP binding//catalytic activity -- -- KOG3351 Predicted nucleotidyltransferase Cluster-8309.36081 BF_2 128.69 0.83 6750 642935882 XP_008198211.1 3848 0.0e+00 PREDICTED: sterile alpha and TIR motif-containing protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IDD9 2775 2.2e-312 Sterile alpha and TIR motif-containing protein 1 OS=Drosophila melanogaster GN=Ect4 PE=2 SV=1 PF13676//PF07647//PF06624//PF00536//PF00514 TIR domain//SAM domain (Sterile alpha motif)//Ribosome associated membrane protein RAMP4//SAM domain (Sterile alpha motif)//Armadillo/beta-catenin-like repeat GO:0007165 signal transduction GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG3678 SARM protein (with sterile alpha and armadillo motifs) Cluster-8309.36083 BF_2 872.00 26.25 1677 91082895 XP_972070.1 995 4.6e-105 PREDICTED: la protein homolog [Tribolium castaneum]>gi|270007069|gb|EFA03517.1| hypothetical protein TcasGA2_TC013519 [Tribolium castaneum] -- -- -- -- -- K11090 LA, SSB lupus La protein http://www.genome.jp/dbget-bin/www_bget?ko:K11090 Q26457 577 5.5e-58 La protein homolog OS=Aedes albopictus PE=1 SV=1 PF00076//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003723//GO:0097159//GO:1901363//GO:0003676 RNA binding//organic cyclic compound binding//heterocyclic compound binding//nucleic acid binding -- -- KOG4213 RNA-binding protein La Cluster-8309.36086 BF_2 23.47 0.51 2196 91093479 XP_968090.1 360 2.6e-31 PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930712|ref|XP_008199997.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930714|ref|XP_008199998.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930716|ref|XP_008199999.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930718|ref|XP_008200000.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|270012666|gb|EFA09114.1| hypothetical protein TcasGA2_TC015974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.36087 BF_2 51.67 0.75 3170 91077370 XP_975175.1 898 1.5e-93 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001655|gb|EEZ98102.1| hypothetical protein TcasGA2_TC000515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28493 580 4.7e-58 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36088 BF_2 8185.49 302.00 1421 332376705 AEE63492.1 543 1.0e-52 unknown [Dendroctonus ponderosae] 332376704 BT128535.1 250 6.74124e-126 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 450 2.5e-43 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF09416 Troponin//RNA helicase (UPF2 interacting domain) GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0005524//GO:0008270//GO:0004386//GO:0003677 ATP binding//zinc ion binding//helicase activity//DNA binding GO:0005861//GO:0005737 troponin complex//cytoplasm KOG3977 Troponin I Cluster-8309.36089 BF_2 2973.99 50.97 2728 91085263 XP_966331.1 2279 9.6e-254 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum]>gi|270009222|gb|EFA05670.1| hypothetical protein TcasGA2_TC014954 [Tribolium castaneum] 826494758 XM_012685372.1 98 4.1044e-41 PREDICTED: Monomorium pharaonis scavenger receptor class B member 1 (LOC105839216), mRNA -- -- -- -- O18824 708 5.8e-73 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155//GO:0007165 cell adhesion//signal transduction GO:0004872 receptor activity GO:0016020//GO:0005764//GO:0016021 membrane//lysosome//integral component of membrane -- -- Cluster-8309.36090 BF_2 1688.91 12.09 6133 642920676 XP_008192517.1 375 1.3e-32 PREDICTED: troponin I isoform X10 [Tribolium castaneum] 332376704 BT128535.1 119 1.96995e-52 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 290 3.9e-24 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF01529//PF00992 DHHC palmitoyltransferase//Troponin -- -- GO:0008270 zinc ion binding GO:0005861 troponin complex -- -- Cluster-8309.36091 BF_2 5388.35 27.94 8354 189237141 XP_973425.2 1853 7.4e-204 PREDICTED: 2-oxoglutarate dehydrogenase, mitochondrial-like isoform X2 [Tribolium castaneum] 817198469 XM_012419460.1 305 1.07731e-155 PREDICTED: Orussus abietinus 2-oxoglutarate dehydrogenase, mitochondrial (LOC105696754), transcript variant X4, mRNA K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q148N0 1550 4.1e-170 2-oxoglutarate dehydrogenase, mitochondrial OS=Bos taurus GN=OGDH PE=2 SV=1 PF06467//PF00676//PF03127 MYM-type Zinc finger with FCS sequence motif//Dehydrogenase E1 component//GAT domain GO:0006886//GO:0008152 intracellular protein transport//metabolic process GO:0016624//GO:0008270 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//zinc ion binding GO:0005622 intracellular KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.36093 BF_2 1224.00 76.10 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36094 BF_2 777.06 42.39 1054 189234794 XP_001807213.1 935 2.6e-98 PREDICTED: protein SMG5 [Tribolium castaneum] -- -- -- -- -- K11125 SMG5, EST1B protein SMG5 http://www.genome.jp/dbget-bin/www_bget?ko:K11125 Q9UPR3 227 1.3e-17 Protein SMG5 OS=Homo sapiens GN=SMG5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36095 BF_2 203.26 2.06 4412 291170320 ADD82416.1 712 7.9e-72 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 402 0 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF01384//PF01395 Phosphate transporter family//PBP/GOBP family GO:0006817 phosphate ion transport GO:0005315//GO:0005549 inorganic phosphate transmembrane transporter activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.36097 BF_2 1644.61 31.17 2494 642937100 XP_008198691.1 1242 1.6e-133 PREDICTED: uncharacterized protein LOC659764 [Tribolium castaneum] -- -- -- -- -- K16315 GSG2 serine/threonine-protein kinase haspin http://www.genome.jp/dbget-bin/www_bget?ko:K16315 P83103 759 6.5e-79 Putative serine/threonine-protein kinase haspin homolog OS=Drosophila melanogaster GN=Haspin PE=2 SV=1 PF07714//PF03121//PF00069 Protein tyrosine kinase//Herpesviridae UL52/UL70 DNA primase//Protein kinase domain GO:0006269//GO:0006260//GO:0006351//GO:0006468 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated//protein phosphorylation GO:0004672//GO:0003896//GO:0005524 protein kinase activity//DNA primase activity//ATP binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2464 Serine/threonine kinase (haspin family) Cluster-8309.36098 BF_2 10645.00 179.28 2771 237681135 NP_001153712.1 2027 1.6e-224 catalase-like [Tribolium castaneum] 391339336 XM_003743960.1 266 1.69608e-134 PREDICTED: Metaseiulus occidentalis catalase-like (LOC100908415), mRNA K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 1756 1.8e-194 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF00199 Catalase GO:0055114//GO:0006804//GO:0006979//GO:0015947//GO:0006568 oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress//methane metabolic process//tryptophan metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-8309.36099 BF_2 188.17 10.20 1059 91079488 XP_968513.1 561 6.1e-55 PREDICTED: probable peptidyl-tRNA hydrolase 2 [Tribolium castaneum]>gi|270003441|gb|EEZ99888.1| hypothetical protein TcasGA2_TC002672 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 O76387 304 1.6e-26 Probable peptidyl-tRNA hydrolase 2 OS=Caenorhabditis elegans GN=C24G6.8 PE=3 SV=1 PF01981 Peptidyl-tRNA hydrolase PTH2 -- -- GO:0004045 aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.361 BF_2 11.63 0.67 1018 642914631 XP_008190292.1 568 9.0e-56 PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|642914633|ref|XP_973587.2| PREDICTED: uncharacterized protein LOC662396 [Tribolium castaneum]>gi|270002275|gb|EEZ98722.1| hypothetical protein TcasGA2_TC001268 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01223 DNA/RNA non-specific endonuclease -- -- GO:0046872//GO:0003676//GO:0016787 metal ion binding//nucleic acid binding//hydrolase activity -- -- -- -- Cluster-8309.36100 BF_2 30006.53 1916.89 942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36101 BF_2 45870.52 604.97 3459 820865920 XP_012349428.1 695 5.8e-70 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105736982 [Apis florea] 32527555 AY210843.1 1463 0 Tenebrio sp. JMM-2003 5.8S ribosomal RNA gene, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 161 2.0e-09 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36102 BF_2 8216.74 570.18 890 642913601 XP_008201081.1 352 8.8e-31 PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZA47 134 6.9e-07 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36103 BF_2 838.72 5.50 6672 189237751 XP_001812575.1 2496 1.6e-278 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 676 7.3e-69 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF08070//PF00787//PF04769 DTHCT (NUC029) region//PX domain//Mating-type protein MAT alpha 1 HMG-box GO:0045895//GO:0006265//GO:0007531 positive regulation of mating-type specific transcription, DNA-templated//DNA topological change//mating type determination GO:0008301//GO:0003918//GO:0035091//GO:0005524//GO:0003677 DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity//phosphatidylinositol binding//ATP binding//DNA binding GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.36105 BF_2 124.20 4.89 1349 642928322 XP_008195533.1 577 1.1e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.0e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.36106 BF_2 301.22 3.50 3891 642919443 XP_974536.2 1971 7.1e-218 PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum]>gi|642919445|ref|XP_008191871.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Tribolium castaneum] 158299880 XM_319893.4 444 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1797 4.4e-199 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF00270//PF00004//PF00096//PF08168//PF04851//PF06221 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Zinc finger, C2H2 type//NUC205 domain//Type III restriction enzyme, res subunit//Putative zinc finger motif, C2HC5-type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0003676//GO:0005524//GO:0016787//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//ATP binding//hydrolase activity//DNA binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.36107 BF_2 18714.74 205.22 4102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36109 BF_2 5380.19 276.21 1102 755856661 XP_011296442.1 357 2.9e-31 PREDICTED: polyubiquitin-B isoform X3 [Musca domestica] 69608590 AM040016.1 261 3.98858e-132 Timarcha balearica mRNA for ubiquitin/ribosomal protein S27Ae fusion protein (ubq/S27Ae gene) K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P0CG60 351 5.9e-32 Polyubiquitin-B OS=Pongo pygmaeus GN=UBB PE=3 SV=1 PF06305//PF14560//PF00240//PF01599 Protein of unknown function (DUF1049)//Ubiquitin-like domain//Ubiquitin family//Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005887//GO:0005840 integral component of plasma membrane//ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.3611 BF_2 1.00 9.01 236 594100882 XP_006073535.1 395 2.4e-36 PREDICTED: 40S ribosomal protein S17 [Bubalus bubalis] 607344326 NR_111944.1 236 6.01967e-119 Homo sapiens ribosomal protein S17 (RPS17), transcript variant 3, non-coding RNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 P0CW22 385 1.4e-36 40S ribosomal protein S17-like OS=Homo sapiens GN=RPS17L PE=1 SV=1 PF00833 Ribosomal S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0187 40S ribosomal protein S17 Cluster-8309.36110 BF_2 73.55 0.66 4933 817011235 AKF11871.1 1486 1.6e-161 putative juvenile hormone epoxide hydrolase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 1230 3.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.36111 BF_2 75.84 1.48 2424 385845164 AFI81409.1 798 4.6e-82 lipoate protein ligase [Phyllotreta striolata] -- -- -- -- -- K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 311 5.6e-27 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF03099//PF08127 Biotin/lipoate A/B protein ligase family//Peptidase family C1 propeptide GO:0006464//GO:0006508//GO:0050790 cellular protein modification process//proteolysis//regulation of catalytic activity GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.36113 BF_2 6387.41 685.38 677 821003176 XP_012365190.1 1127 9.1e-121 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 665807220 XM_008553656.1 320 3.82418e-165 PREDICTED: Microplitis demolitor polyubiquitin-A (LOC103574248), mRNA K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 1127 3.7e-122 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF14560//PF00240//PF04452 Ubiquitin-like domain//Ubiquitin family//RNA methyltransferase GO:0006364 rRNA processing GO:0005515//GO:0008168 protein binding//methyltransferase activity -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.36114 BF_2 320.60 2.44 5778 91083731 XP_970731.1 1545 2.6e-168 PREDICTED: tyrosine aminotransferase [Tribolium castaneum]>gi|270006803|gb|EFA03251.1| hypothetical protein TcasGA2_TC013185 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 1098 7.4e-118 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF02854//PF04834//PF11095//PF01053//PF01212//PF00155 MIF4G domain//Early E3 14.5 kDa protein//Gem-associated protein 7 (Gemin7)//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Aminotransferase class I and II GO:0009094//GO:0006103//GO:0000162//GO:0006520//GO:0009821//GO:0009072//GO:0006571//GO:0009058//GO:0009966//GO:0006536 L-phenylalanine biosynthetic process//2-oxoglutarate metabolic process//tryptophan biosynthetic process//cellular amino acid metabolic process//alkaloid biosynthetic process//aromatic amino acid family metabolic process//tyrosine biosynthetic process//biosynthetic process//regulation of signal transduction//glutamate metabolic process GO:0003723//GO:0004838//GO:0030170//GO:0005515//GO:0016829 RNA binding//L-tyrosine:2-oxoglutarate aminotransferase activity//pyridoxal phosphate binding//protein binding//lyase activity GO:0032797//GO:0016021 SMN complex//integral component of membrane KOG0259 Tyrosine aminotransferase Cluster-8309.36115 BF_2 314.14 2.75 5065 642937921 XP_008199131.1 1313 1.8e-141 PREDICTED: synapsin, partial [Tribolium castaneum] 645024540 XM_008215666.1 69 1.01314e-24 PREDICTED: Nasonia vitripennis synapsin (LOC100114347), mRNA -- -- -- -- Q6QM28 795 8.8e-83 Synapsin OS=Helix pomatia GN=SYN PE=1 SV=1 PF02786//PF13673//PF15096 Carbamoyl-phosphate synthase L chain, ATP binding domain//Acetyltransferase (GNAT) domain//G6B family GO:0042967 acyl-carrier-protein biosynthetic process GO:0005524//GO:0008080 ATP binding//N-acetyltransferase activity GO:0016021 integral component of membrane KOG3895 Synaptic vesicle protein Synapsin Cluster-8309.36116 BF_2 37.77 0.53 3249 270009835 EFA06283.1 505 5.8e-48 hypothetical protein TcasGA2_TC009149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFB8 147 7.8e-08 Tetratricopeptide repeat protein 37 OS=Xenopus laevis GN=ttc37 PE=2 SV=1 PF13374//PF00515//PF13414//PF13176//PF06481//PF13181//PF13174//PF16045 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//COX Aromatic Rich Motif//Tetratricopeptide repeat//Tetratricopeptide repeat//LisH GO:0006118//GO:0022900//GO:0055114 obsolete electron transport//electron transport chain//oxidation-reduction process GO:0008827//GO:0005515 cytochrome o ubiquinol oxidase activity//protein binding GO:0016021//GO:0009319 integral component of membrane//cytochrome o ubiquinol oxidase complex -- -- Cluster-8309.36117 BF_2 7.66 0.37 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36118 BF_2 221.35 2.00 4908 780140340 XP_011680553.1 564 1.3e-54 PREDICTED: titin [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q23551 541 2.4e-53 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF00041//PF13895//PF16656//PF00319 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//SRF-type transcription factor (DNA-binding and dimerisation domain) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046983//GO:0005515//GO:0046872//GO:0003993//GO:0003677 protein dimerization activity//protein binding//metal ion binding//acid phosphatase activity//DNA binding -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.36119 BF_2 4957.83 475.85 723 264667385 ACY71278.1 688 7.8e-70 ribosomal protein S11 [Chrysomela tremula] 565446497 XM_006284601.1 48 6.55411e-14 Capsella rubella hypothetical protein (CARUB_v10005922mg) mRNA, complete cds K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P41115 603 2.3e-61 40S ribosomal protein S11 OS=Xenopus laevis GN=rps11 PE=2 SV=1 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.3612 BF_2 2.00 0.42 488 -- -- -- -- -- 440546405 NM_001272054.1 488 0 Homo sapiens Morf4 family associated protein 1 (MRFAP1), transcript variant 3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36120 BF_2 2571.03 79.74 1636 189234118 XP_001811130.1 634 3.2e-63 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] 153907106 AK262902.1 40 4.26309e-09 Gryllus bimaculatus mRNA, GBcontig09763 -- -- -- -- -- -- -- -- PF05757//PF09726 Oxygen evolving enhancer protein 3 (PsbQ)//Transmembrane protein GO:0015979 photosynthesis GO:0005509 calcium ion binding GO:0016021//GO:0019898//GO:0009654//GO:0009523 integral component of membrane//extrinsic component of membrane//photosystem II oxygen evolving complex//photosystem II -- -- Cluster-8309.36123 BF_2 21330.73 84.24 10880 642911258 XP_008199793.1 10422 0.0e+00 PREDICTED: filamin-A isoform X3 [Tribolium castaneum] 642911257 XM_008201571.1 1826 0 PREDICTED: Tribolium castaneum filamin-A (LOC661488), transcript variant X3, mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q9VEN1 7814 0.0e+00 Filamin-A OS=Drosophila melanogaster GN=cher PE=1 SV=2 PF00307//PF00688//PF01105 Calponin homology (CH) domain//TGF-beta propeptide//emp24/gp25L/p24 family/GOLD GO:0007165//GO:0040007//GO:0008283//GO:0006810 signal transduction//growth//cell proliferation//transport GO:0008083//GO:0005515 growth factor activity//protein binding GO:0016021 integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.36126 BF_2 202.32 1.31 6737 189236205 XP_970721.2 2302 5.1e-256 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 120 6.01701e-53 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q8BJ56 585 2.6e-58 Patatin-like phospholipase domain-containing protein 2 OS=Mus musculus GN=Pnpla2 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.36127 BF_2 923.31 17.69 2471 189236205 XP_970721.2 2504 7.1e-280 PREDICTED: patatin-like phospholipase domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270005558|gb|EFA02006.1| hypothetical protein TcasGA2_TC007628 [Tribolium castaneum] 569534448 KF724681.1 127 2.81175e-57 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q8BJ56 699 5.8e-72 Patatin-like phospholipase domain-containing protein 2 OS=Mus musculus GN=Pnpla2 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.36128 BF_2 28.43 1.12 1351 270001100 EEZ97547.1 288 3.5e-23 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] -- -- -- -- -- K16175 SCRIB protein scribble http://www.genome.jp/dbget-bin/www_bget?ko:K16175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36130 BF_2 3061.36 49.05 2898 478257447 ENN77603.1 709 1.2e-71 hypothetical protein YQE_05898, partial [Dendroctonus ponderosae]>gi|546679842|gb|ERL90230.1| hypothetical protein D910_07583 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SQH8 260 5.5e-21 Uncharacterized protein C6orf136 OS=Homo sapiens GN=C6orf136 PE=2 SV=1 PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0042575 DNA polymerase complex KOG4457 Uncharacterized conserved protein Cluster-8309.36131 BF_2 102.69 1.12 4109 91093345 XP_967700.1 926 1.1e-96 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X9 [Tribolium castaneum] 642938317 XM_962607.3 231 7.22431e-115 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X10, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 P81269 205 1.9e-14 Cyclic AMP-dependent transcription factor ATF-1 OS=Mus musculus GN=Atf1 PE=1 SV=1 PF12387//PF03131//PF07716//PF00170//PF02173 Pestivirus NS2 peptidase//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor//pKID domain GO:0006144//GO:0006508//GO:0006355 purine nucleobase metabolic process//proteolysis//regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0070008//GO:0003968//GO:0017111//GO:0016817//GO:0004197//GO:0043565//GO:0004252//GO:0003700 DNA binding//protein binding//serine-type exopeptidase activity//RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//hydrolase activity, acting on acid anhydrides//cysteine-type endopeptidase activity//sequence-specific DNA binding//serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0031379 nucleus//transcription factor complex//RNA-directed RNA polymerase complex -- -- Cluster-8309.36132 BF_2 1202.00 69.37 1012 642925630 XP_008194648.1 994 3.6e-105 PREDICTED: proteasome subunit beta type-3 [Tribolium castaneum]>gi|270008657|gb|EFA05105.1| hypothetical protein TcasGA2_TC015205 [Tribolium castaneum] 642925629 XM_008196426.1 197 1.38035e-96 PREDICTED: Tribolium castaneum proteasome subunit beta type-3 (LOC662410), mRNA K02735 PSMB3 20S proteasome subunit beta 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02735 Q9XYN7 797 1.0e-83 Proteasome subunit beta type-3 OS=Drosophila melanogaster GN=Prosbeta3 PE=1 SV=1 PF00227//PF03348 Proteasome subunit//Serine incorporator (Serinc) GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839//GO:0016020 cytoplasm//nucleus//proteasome core complex//membrane KOG0180 20S proteasome, regulatory subunit beta type PSMB3/PUP3 Cluster-8309.36133 BF_2 42.07 0.52 3672 282165741 NP_001164113.1 2452 1.1e-273 cap-n-collar [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 5.2e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF07716//PF00170//PF03131//PF03126 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor//Plus-3 domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3863 bZIP transcription factor NRF1 Cluster-8309.36134 BF_2 2003.27 9.43 9178 817065912 XP_012254772.1 7951 0.0e+00 PREDICTED: translational activator GCN1 [Athalia rosae] 820859669 XM_003697079.2 474 0 PREDICTED: Apis florea translational activator GCN1 (LOC100865997), mRNA -- -- -- -- Q92616 5791 0.0e+00 Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=6 PF01602//PF04546//PF00042//PF08064//PF02269//PF02985//PF00125 Adaptin N terminal region//Sigma-70, non-essential region//Globin//UME (NUC010) domain//Transcription initiation factor IID, 18kD subunit//HEAT repeat//Core histone H2A/H2B/H3/H4 GO:0006366//GO:0016310//GO:0006352//GO:0009069//GO:0016192//GO:0006886//GO:0006355 transcription from RNA polymerase II promoter//phosphorylation//DNA-templated transcription, initiation//serine family amino acid metabolic process//vesicle-mediated transport//intracellular protein transport//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0020037//GO:0016987//GO:0019825//GO:0003700//GO:0004674 protein binding//DNA binding//heme binding//sigma factor activity//oxygen binding//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity GO:0005667//GO:0030117 transcription factor complex//membrane coat KOG1242 Protein containing adaptin N-terminal region Cluster-8309.36135 BF_2 49.18 0.41 5346 189239886 XP_969203.2 1791 7.3e-197 PREDICTED: protein tweety [Tribolium castaneum] 642931168 XM_964110.3 243 2.01008e-121 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1074 4.1e-115 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36136 BF_2 888.82 19.36 2208 194363749 NP_001123908.1 2107 6.9e-234 cytochrome P450 CYP18A1 [Tribolium castaneum]>gi|270014221|gb|EFA10669.1| cytochrome P450 18A1 [Tribolium castaneum] 658847169 XM_008407855.1 40 5.7862e-09 PREDICTED: Poecilia reticulata cytochrome P450 2J1-like (LOC103464052), mRNA K14985 CYP18A1 26-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K14985 Q95078 1439 8.1e-158 Cytochrome P450 18a1 OS=Drosophila melanogaster GN=Cyp18a1 PE=2 SV=2 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0005506//GO:0016712//GO:0020037 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen//heme binding -- -- KOG0156 Cytochrome P450 CYP2 subfamily Cluster-8309.36137 BF_2 844.10 44.43 1082 91082539 XP_973726.1 648 5.1e-65 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 1.7e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.36138 BF_2 79.80 0.75 4735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36139 BF_2 31.71 1.06 1537 91090290 XP_971485.1 917 4.6e-96 PREDICTED: bax inhibitor 1 [Tribolium castaneum]>gi|270013796|gb|EFA10244.1| hypothetical protein TcasGA2_TC012443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7R1 591 1.2e-59 Bax inhibitor 1 OS=Pongo abelii GN=TMBIM6 PE=2 SV=2 -- -- GO:0043066 negative regulation of apoptotic process -- -- GO:0016021 integral component of membrane KOG1629 Bax-mediated apoptosis inhibitor TEGT/BI-1 Cluster-8309.36142 BF_2 7633.00 288.75 1393 332375238 AEE62760.1 561 8.0e-55 unknown [Dendroctonus ponderosae]>gi|478259298|gb|ENN79200.1| hypothetical protein YQE_04384, partial [Dendroctonus ponderosae]>gi|546681740|gb|ERL91772.1| hypothetical protein D910_09098 [Dendroctonus ponderosae] 332375237 BT127798.1 174 1.16962e-83 Dendroctonus ponderosae clone DPO058_I06 unknown mRNA K01527 EGD1, BTF3 nascent polypeptide-associated complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01527 Q18885 420 7.4e-40 Transcription factor BTF3 homolog OS=Caenorhabditis elegans GN=icd-1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2240 RNA polymerase II general transcription factor BTF3 and related proteins Cluster-8309.36143 BF_2 1449.43 11.67 5483 91094499 XP_971436.1 1375 1.3e-148 PREDICTED: phosphopantothenate--cysteine ligase [Tribolium castaneum]>gi|270000749|gb|EEZ97196.1| hypothetical protein TcasGA2_TC004384 [Tribolium castaneum] -- -- -- -- -- K01922 PPCS, coaB phosphopantothenate-cysteine ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01922 Q9HAB8 616 5.5e-62 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2728 Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase Cluster-8309.36144 BF_2 2553.38 26.81 4271 189240108 XP_972976.2 3649 0.0e+00 PREDICTED: trifunctional purine biosynthetic protein adenosine-3 [Tribolium castaneum]>gi|270011705|gb|EFA08153.1| hypothetical protein TcasGA2_TC005772 [Tribolium castaneum] 686609239 XM_009282957.1 67 1.10365e-23 PREDICTED: Aptenodytes forsteri trifunctional purine biosynthetic protein adenosine-3 (LOC103901972), mRNA K11787 GART phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K11787 P21872 2756 3.0e-310 Trifunctional purine biosynthetic protein adenosine-3 OS=Gallus gallus GN=GART PE=2 SV=1 PF02843//PF02844//PF02786//PF00551//PF02655 Phosphoribosylglycinamide synthetase, C domain//Phosphoribosylglycinamide synthetase, N domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//Formyl transferase//ATP-grasp domain GO:0006189//GO:0009113//GO:0006144//GO:0046653//GO:0009058//GO:0009256//GO:0032259 'de novo' IMP biosynthetic process//purine nucleobase biosynthetic process//purine nucleobase metabolic process//tetrahydrofolate metabolic process//biosynthetic process//10-formyltetrahydrofolate metabolic process//methylation GO:0005524//GO:0004641//GO:0016742//GO:0004637//GO:0008168//GO:0046872//GO:0004644 ATP binding//phosphoribosylformylglycinamidine cyclo-ligase activity//hydroxymethyl-, formyl- and related transferase activity//phosphoribosylamine-glycine ligase activity//methyltransferase activity//metal ion binding//phosphoribosylglycinamide formyltransferase activity GO:0005737 cytoplasm KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS) Cluster-8309.36145 BF_2 700.89 12.53 2627 642923827 XP_008193896.1 1863 1.6e-205 PREDICTED: endonuclease/exonuclease/phosphatase family domain-containing protein 1-like [Tribolium castaneum]>gi|270007767|gb|EFA04215.1| hypothetical protein TcasGA2_TC014464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEQ0 642 2.5e-65 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Danio rerio GN=eepd1 PE=2 SV=1 PF00633//PF06514//PF03934 Helix-hairpin-helix motif//Photosystem II 12 kDa extrinsic protein (PsbU)//Type II secretion system (T2SS), protein K GO:0042549//GO:0009306//GO:0006281//GO:0015979 photosystem II stabilization//protein secretion//DNA repair//photosynthesis GO:0003677 DNA binding GO:0009523//GO:0009654//GO:0019898//GO:0016021 photosystem II//photosystem II oxygen evolving complex//extrinsic component of membrane//integral component of membrane -- -- Cluster-8309.36146 BF_2 517.00 4.15 5498 332375580 AEE62931.1 1344 5.1e-145 unknown [Dendroctonus ponderosae]>gi|478259047|gb|ENN78990.1| hypothetical protein YQE_04541, partial [Dendroctonus ponderosae]>gi|546678360|gb|ERL88993.1| hypothetical protein D910_06371 [Dendroctonus ponderosae] 752869446 XM_011253537.1 134 8.09537e-61 PREDICTED: Camponotus floridanus cytochrome c oxidase assembly protein COX11, mitochondrial (LOC105248637), transcript variant X3, mRNA K15407 QTRTD1 queuine tRNA-ribosyltransferase subunit QTRTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15407 Q16RF5 720 4.8e-74 Queuine tRNA-ribosyltransferase subunit QTRTD1 homolog OS=Aedes aegypti GN=AAEL010968 PE=3 SV=1 PF01567//PF04442//PF01702 Hantavirus glycoprotein G1//Cytochrome c oxidase assembly protein CtaG/Cox11//Queuine tRNA-ribosyltransferase GO:0006400//GO:0030683//GO:0008616 tRNA modification//evasion or tolerance by virus of host immune response//queuosine biosynthetic process GO:0005507//GO:0008479 copper ion binding//queuine tRNA-ribosyltransferase activity GO:0019012 virion KOG2540 Cytochrome oxidase assembly factor COX11 Cluster-8309.36147 BF_2 452.29 11.10 1992 642931814 XP_008196744.1 1778 8.7e-196 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1209 3.4e-131 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.36148 BF_2 905.00 33.78 1408 91092178 XP_968474.1 835 1.4e-86 PREDICTED: ras-related protein Rap-2c [Tribolium castaneum]>gi|270014441|gb|EFA10889.1| hypothetical protein TcasGA2_TC001713 [Tribolium castaneum] 60098716 AJ851555.1 78 2.74739e-30 Gallus gallus mRNA for hypothetical protein, clone 6p4 K07839 RAP2C Ras-related protein Rap-2C http://www.genome.jp/dbget-bin/www_bget?ko:K07839 Q9Y3L5 621 3.7e-63 Ras-related protein Rap-2c OS=Homo sapiens GN=RAP2C PE=1 SV=1 PF01637//PF01926//PF08477//PF03193//PF02421//PF00025//PF00071 Archaeal ATPase//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//Ferrous iron transport protein B//ADP-ribosylation factor family//Ras family GO:0006184//GO:0015684//GO:0007264 obsolete GTP catabolic process//ferrous iron transport//small GTPase mediated signal transduction GO:0005524//GO:0015093//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//GTP binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0395 Ras-related GTPase Cluster-8309.36149 BF_2 298.38 6.36 2250 642916737 XP_008192408.1 1649 9.0e-181 PREDICTED: homeobox protein araucan isoform X3 [Tribolium castaneum] 642916736 XM_008194186.1 791 0 PREDICTED: Tribolium castaneum homeobox protein araucan (LOC652944), transcript variant X3, mRNA -- -- -- -- Q24248 725 5.1e-75 Homeobox protein araucan OS=Drosophila melanogaster GN=ara PE=1 SV=2 PF00046//PF04931//PF00335//PF05920 Homeobox domain//DNA polymerase phi//Tetraspanin family//Homeobox KN domain GO:0006355//GO:0006351//GO:0006260 regulation of transcription, DNA-templated//transcription, DNA-templated//DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.36150 BF_2 1093.52 8.84 5464 91095331 XP_975275.1 3723 0.0e+00 PREDICTED: von Willebrand factor A domain-containing protein 8 [Tribolium castaneum]>gi|270017220|gb|EFA13666.1| hypothetical protein TcasGA2_TC004261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC88 2294 1.4e-256 von Willebrand factor A domain-containing protein 8 OS=Mus musculus GN=Vwa8 PE=2 SV=2 PF00421//PF00004//PF07728//PF08477//PF01695//PF01926//PF00158//PF00493//PF04670//PF00910//PF03193//PF07726//PF00005//PF00006//PF01637//PF07724//PF01443 Photosystem II protein//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//IstB-like ATP binding protein//50S ribosome-binding GTPase//Sigma-54 interaction domain//MCM2/3/5 family//Gtr1/RagA G protein conserved region//RNA helicase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//AAA domain (Cdc48 subfamily)//Viral (Superfamily 1) RNA helicase GO:0007264//GO:0009767//GO:0019684//GO:0006355//GO:0006260 small GTPase mediated signal transduction//photosynthetic electron transport chain//photosynthesis, light reaction//regulation of transcription, DNA-templated//DNA replication GO:0003723//GO:0003677//GO:0017111//GO:0003724//GO:0005525//GO:0008134//GO:0003924//GO:0005524//GO:0016168//GO:0000166//GO:0016887 RNA binding//DNA binding//nucleoside-triphosphatase activity//RNA helicase activity//GTP binding//transcription factor binding//GTPase activity//ATP binding//chlorophyll binding//nucleotide binding//ATPase activity GO:0005667//GO:0016020//GO:0009521 transcription factor complex//membrane//photosystem KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.36153 BF_2 407.18 15.64 1376 91089929 XP_973045.1 495 3.6e-47 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00436 Single-strand binding protein family -- -- GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.36154 BF_2 4164.95 77.51 2535 264667403 ACY71287.1 544 1.4e-52 ribosomal protein L35A [Chrysomela tremula] 389610812 AK402395.1 47 8.55057e-13 Papilio polytes mRNA for ribosomal protein L35A, complete cds, sequence id: Pp-0167 K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P18077 367 1.9e-33 60S ribosomal protein L35a OS=Homo sapiens GN=RPL35A PE=1 SV=2 PF01782//PF01247 RimM N-terminal domain//Ribosomal protein L35Ae GO:0006364//GO:0042254//GO:0006412 rRNA processing//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-8309.36155 BF_2 5881.00 174.01 1701 91088233 XP_973769.1 723 1.6e-73 PREDICTED: elongation factor 1-beta' [Tribolium castaneum]>gi|270011822|gb|EFA08270.1| hypothetical protein TcasGA2_TC005900 [Tribolium castaneum] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P29522 600 1.2e-60 Elongation factor 1-beta' OS=Bombyx mori PE=1 SV=2 PF00736//PF05209 EF-1 guanine nucleotide exchange domain//Septum formation inhibitor MinC, N-terminal domain GO:0006414//GO:0051302//GO:0006448//GO:0006412 translational elongation//regulation of cell division//regulation of translational elongation//translation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.36156 BF_2 113.02 3.67 1575 332375240 AEE62761.1 1172 1.3e-125 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O35075 845 4.4e-89 Down syndrome critical region protein 3 homolog OS=Mus musculus GN=Dscr3 PE=2 SV=1 PF08923 Mitogen-activated protein kinase kinase 1 interacting GO:0032006 regulation of TOR signaling -- -- -- -- KOG2717 Uncharacterized conserved protein with similarity to embryogenesis protein H beta 58 and VPS26 Cluster-8309.36157 BF_2 431957.55 8593.03 2390 752822710 AJG42379.1 1960 8.2e-217 actin [Leptinotarsa decemlineata] 55783599 AY817141.1 1311 0 Apriona germari actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41339 1908 3.6e-212 Actin, acrosomal process isoform OS=Limulus polyphemus PE=2 SV=1 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- KOG0676 Actin and related proteins Cluster-8309.36158 BF_2 2723.24 268.14 712 478263483 ENN81838.1 154 6.4e-08 hypothetical protein YQE_01777, partial [Dendroctonus ponderosae]>gi|546685487|gb|ERL94985.1| hypothetical protein D910_12257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36160 BF_2 361.99 6.40 2652 270005721 EFA02169.1 729 5.1e-74 hypothetical protein TcasGA2_TC007825 [Tribolium castaneum] -- -- -- -- -- K16751 C2CD3 C2 domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16751 Q4AC94 264 1.7e-21 C2 domain-containing protein 3 OS=Homo sapiens GN=C2CD3 PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36161 BF_2 1886.58 33.80 2622 755959123 XP_011304293.1 2156 1.7e-239 PREDICTED: eukaryotic peptide chain release factor subunit 1 isoform X1 [Fopius arisanus] 642912506 XM_966575.3 612 0 PREDICTED: Tribolium castaneum eukaryotic peptide chain release factor subunit 1 (LOC660337), mRNA K03265 ETF1, ERF1 peptide chain release factor subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03265 Q9VPH7 2131 5.5e-238 Eukaryotic peptide chain release factor subunit 1 OS=Drosophila melanogaster GN=eRF1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0688 Peptide chain release factor 1 (eRF1) Cluster-8309.36162 BF_2 1497.54 10.54 6231 642911068 XP_008200561.1 1616 1.7e-176 PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum]>gi|642911070|ref|XP_008200562.1| PREDICTED: ELAV-like protein 3 isoform X1 [Tribolium castaneum] 642911069 XM_008202340.1 536 0 PREDICTED: Tribolium castaneum ELAV-like protein 4 (LOC659897), transcript variant X2, mRNA K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 Q7SZT7 1034 2.1e-110 ELAV-like protein 4 OS=Xenopus laevis GN=elavl4 PE=2 SV=1 PF16367//PF00076//PF08675 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0046872//GO:0003676//GO:0004535 RNA binding//metal ion binding//nucleic acid binding//poly(A)-specific ribonuclease activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.36164 BF_2 269.50 15.55 1012 270003477 EEZ99924.1 1199 6.1e-129 hypothetical protein TcasGA2_TC002717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 947 4.2e-101 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF13417//PF07651 Glutathione S-transferase, N-terminal domain//ANTH domain -- -- GO:0005515//GO:0005543 protein binding//phospholipid binding -- -- KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.36165 BF_2 2297.50 18.83 5391 546676782 ERL87728.1 270 1.7e-20 hypothetical protein D910_05118 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36166 BF_2 486.78 5.09 4285 642912316 XP_969236.2 1319 3.1e-142 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IF69 769 7.7e-80 NHL repeat-containing protein 2 OS=Bos taurus GN=NHLRC2 PE=2 SV=1 PF01731//PF01436//PF00085//PF00578 Arylesterase//NHL repeat//Thioredoxin//AhpC/TSA family GO:0055114//GO:0045454 oxidation-reduction process//cell redox homeostasis GO:0016209//GO:0016491//GO:0005515//GO:0004064 antioxidant activity//oxidoreductase activity//protein binding//arylesterase activity -- -- -- -- Cluster-8309.36167 BF_2 184.02 1.64 4985 642913546 XP_008201056.1 1646 4.4e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 2.2e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF06007//PF07690//PF00083 Phosphonate metabolism protein PhnJ//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0019700//GO:0042916 transmembrane transport//organic phosphonate catabolic process//alkylphosphonate transport GO:0022857//GO:0016829 transmembrane transporter activity//lyase activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.36170 BF_2 21.55 0.37 2708 91079832 XP_970236.1 695 4.5e-70 PREDICTED: protein enabled isoform X1 [Tribolium castaneum]>gi|270003288|gb|EEZ99735.1| hypothetical protein TcasGA2_TC002504 [Tribolium castaneum] 642918238 XM_008193203.1 137 8.51198e-63 PREDICTED: Tribolium castaneum protein enabled (LOC658784), transcript variant X2, mRNA K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 462 1.9e-44 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 PF04939//PF04800//PF00638 Ribosome biogenesis regulatory protein (RRS1)//ETC complex I subunit conserved region//RanBP1 domain GO:0022900//GO:0046907//GO:0042254 electron transport chain//intracellular transport//ribosome biogenesis GO:0016651 oxidoreductase activity, acting on NAD(P)H GO:0005634 nucleus KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.36171 BF_2 4477.28 32.29 6087 91084173 XP_966383.1 1434 2.1e-155 PREDICTED: serine/threonine-protein kinase pelle [Tribolium castaneum]>gi|270009272|gb|EFA05720.1| pelle [Tribolium castaneum] -- -- -- -- -- K04733 IRAK4 interleukin-1 receptor-associated kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04733 Q05652 685 6.0e-70 Serine/threonine-protein kinase pelle OS=Drosophila melanogaster GN=pll PE=1 SV=1 PF00069//PF00531//PF07714 Protein kinase domain//Death domain//Protein tyrosine kinase GO:0007165//GO:0009987//GO:0006468 signal transduction//cellular process//protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG1187 Serine/threonine protein kinase Cluster-8309.36172 BF_2 687.38 20.64 1680 546685827 ERL95270.1 1821 7.6e-201 hypothetical protein D910_12536 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 656 3.8e-67 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36173 BF_2 370.09 1.96 8166 546673207 ERL84861.1 1263 1.9e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.2e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF00005//PF03824//PF03193//PF17078//PF00503//PF15458//PF04548//PF02183//PF06156//PF00437//PF00312//PF06005//PF05529//PF01066 ABC transporter//High-affinity nickel-transport protein//Protein of unknown function, DUF258//SWI5-dependent HO expression protein 3//G-protein alpha subunit//Nineteen complex-related protein 2//AIG1 family//Homeobox associated leucine zipper//Protein of unknown function (DUF972)//Type II/IV secretion system protein//Ribosomal protein S15//Protein of unknown function (DUF904)//B-cell receptor-associated protein 31-like//CDP-alcohol phosphatidyltransferase GO:0042254//GO:0035444//GO:0006260//GO:0051028//GO:0048309//GO:0015675//GO:0000390//GO:0007186//GO:0006355//GO:0006886//GO:0006810//GO:0007165//GO:0008654//GO:0000917//GO:0043093//GO:0006412 ribosome biogenesis//nickel cation transmembrane transport//DNA replication//mRNA transport//endoplasmic reticulum inheritance//nickel cation transport//spliceosomal complex disassembly//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//intracellular protein transport//transport//signal transduction//phospholipid biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//translation GO:0003700//GO:0003735//GO:0019001//GO:0016887//GO:0003924//GO:0005524//GO:0031683//GO:0046872//GO:0043565//GO:0015099//GO:0005525//GO:0004871//GO:0016780 transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//guanyl nucleotide binding//ATPase activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//metal ion binding//sequence-specific DNA binding//nickel cation transmembrane transporter activity//GTP binding//signal transducer activity//phosphotransferase activity, for other substituted phosphate groups GO:0005667//GO:0071008//GO:0005737//GO:0005840//GO:0005622//GO:0016021//GO:0016020//GO:0005783 transcription factor complex//U2-type post-mRNA release spliceosomal complex//cytoplasm//ribosome//intracellular//integral component of membrane//membrane//endoplasmic reticulum KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.36175 BF_2 547.78 2.73 8686 642911061 XP_008200558.1 3420 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2804 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520//PF00813 Ion transport protein//FliP family GO:0055085//GO:0009306//GO:0006811 transmembrane transport//protein secretion//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.36176 BF_2 395.00 5.51 3288 91085657 XP_971289.1 2534 3.1e-283 PREDICTED: uncharacterized protein LOC659930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P27393 181 9.0e-12 Collagen alpha-2(IV) chain OS=Ascaris suum PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.36178 BF_2 12.90 0.54 1284 642940077 XP_008192917.1 1068 1.2e-113 PREDICTED: UPF0489 protein C5orf22 homolog isoform X1 [Tribolium castaneum]>gi|270016013|gb|EFA12461.1| hypothetical protein TcasGA2_TC010608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PAE6 584 6.5e-59 UPF0489 protein C5orf22 homolog OS=Xenopus laevis PE=2 SV=1 PF01668 SmpB protein -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.36179 BF_2 42830.60 792.14 2549 642913818 XP_008201172.1 643 4.6e-64 PREDICTED: myosin light chain alkali isoform X1 [Tribolium castaneum] 642913817 XM_008202950.1 253 2.62816e-127 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 455 1.2e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF00036//PF13405//PF13499 EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.36180 BF_2 326.00 7.31 2154 91082503 XP_976395.1 305 6.0e-25 PREDICTED: uncharacterized protein LOC661760 [Tribolium castaneum]>gi|270007133|gb|EFA03581.1| hypothetical protein TcasGA2_TC013664 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36182 BF_2 453.95 13.16 1730 91084289 XP_967046.1 908 5.8e-95 PREDICTED: ras-related protein Rab-35 [Tribolium castaneum]>gi|270008813|gb|EFA05261.1| hypothetical protein TcasGA2_TC015416 [Tribolium castaneum] 765118842 XM_004068360.2 35 2.71636e-06 PREDICTED: Oryzias latipes ras-related protein Rab-8A (LOC101161304), mRNA K07876 RAB35, RAB1C Ras-related protein Rab-35 http://www.genome.jp/dbget-bin/www_bget?ko:K07876 Q6PHN9 769 3.1e-80 Ras-related protein Rab-35 OS=Mus musculus GN=Rab35 PE=1 SV=1 PF02421//PF00025//PF07728//PF08477//PF01926//PF10662//PF00071//PF04670//PF03193//PF00005//PF01637 Ferrous iron transport protein B//ADP-ribosylation factor family//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region//Protein of unknown function, DUF258//ABC transporter//Archaeal ATPase GO:0006576//GO:0015684//GO:0015031//GO:0007264 cellular biogenic amine metabolic process//ferrous iron transport//protein transport//small GTPase mediated signal transduction GO:0015093//GO:0005524//GO:0003924//GO:0016887//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.36183 BF_2 3283.37 36.83 4016 189238116 XP_001814107.1 722 5.0e-73 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00064//PF17050 Neuraminidase//Altered inheritance of mitochondria 5 GO:0042407//GO:0006687//GO:0005975 cristae formation//glycosphingolipid metabolic process//carbohydrate metabolic process GO:0004308 exo-alpha-sialidase activity GO:0016020//GO:0033644//GO:0061617//GO:0055036//GO:0044284 membrane//host cell membrane//MICOS complex//virion membrane//mitochondrial crista junction -- -- Cluster-8309.36184 BF_2 269.56 4.32 2895 642915176 XP_008190506.1 292 2.6e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36185 BF_2 409.37 6.29 3008 282848149 NP_001164293.1 1147 1.9e-122 kayak isoform B [Tribolium castaneum] -- -- -- -- -- K09031 FOSLN fos-like antigen, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09031 B4K617 198 8.8e-14 Transcription factor kayak OS=Drosophila mojavensis GN=kay PE=3 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36186 BF_2 46.05 0.53 3911 642929255 XP_008195756.1 1279 1.2e-137 PREDICTED: PX domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270009666|gb|EFA06114.1| hypothetical protein TcasGA2_TC008957 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q8BX57 761 6.0e-79 PX domain-containing protein kinase-like protein OS=Mus musculus GN=Pxk PE=1 SV=2 PF00787//PF02205//PF02285 PX domain//WH2 motif//Cytochrome oxidase c subunit VIII GO:0006123//GO:0006468//GO:0007154//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//protein phosphorylation//cell communication//proton transport GO:0005524//GO:0035091//GO:0003779//GO:0004672//GO:0004129 ATP binding//phosphatidylinositol binding//actin binding//protein kinase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.36187 BF_2 140.92 4.75 1527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36189 BF_2 2624.00 485.78 513 264667451 ACY71311.1 406 2.8e-37 ribosomal protein L37A [Chrysomela tremula] 264667450 GU120461.1 174 4.12682e-84 Chrysomela tremulae ribosomal protein L37A (RpL37A) mRNA, complete cds K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 Q9VMU4 374 5.8e-35 60S ribosomal protein L37a OS=Drosophila melanogaster GN=RpL37A PE=1 SV=3 PF01780 Ribosomal L37ae protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0402 60S ribosomal protein L37 Cluster-8309.36190 BF_2 77.06 1.12 3170 820865920 XP_012349428.1 676 8.5e-68 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105736982 [Apis florea] 37223294 AY310671.1 1367 0 Diaperinae sp. JAR-2003 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 174 5.6e-11 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36191 BF_2 161.05 0.70 9894 642934437 XP_008197662.1 3342 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X1 [Tribolium castaneum]>gi|270013709|gb|EFA10157.1| hypothetical protein TcasGA2_TC012345 [Tribolium castaneum] 642934440 XM_008199442.1 78 1.97116e-29 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 1262 1.2e-136 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF02178//PF12125//PF08392//PF04947//PF00628 AT hook motif//D domain of beta-TrCP//FAE1/Type III polyketide synthase-like protein//Poxvirus Late Transcription Factor VLTF3 like//PHD-finger GO:0006633//GO:0046782 fatty acid biosynthetic process//regulation of viral transcription GO:0003677//GO:0046983//GO:0005515//GO:0005488//GO:0016747 DNA binding//protein dimerization activity//protein binding//binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016020 membrane KOG1473 Nucleosome remodeling factor, subunit NURF301/BPTF Cluster-8309.36192 BF_2 61.05 1.81 1698 571516260 XP_006569195.1 224 1.2e-15 PREDICTED: histidine-rich glycoprotein-like [Apis mellifera] -- -- -- -- -- -- -- -- -- P04929 188 7.2e-13 Histidine-rich glycoprotein OS=Plasmodium lophurae PE=4 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36193 BF_2 34211.00 1900.98 1040 21218346 AAM44043.1 779 3.2e-80 ferritin 1 [Apriona germari] 21218345 AF509878.1 275 6.19851e-140 Apriona germari ferritin 1 mRNA, complete cds K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P41822 350 7.2e-32 Ferritin subunit OS=Aedes aegypti GN=FERH PE=1 SV=2 PF00210//PF02915 Ferritin-like domain//Rubrerythrin GO:0055114//GO:0006879 oxidation-reduction process//cellular iron ion homeostasis GO:0046872//GO:0016491//GO:0008199 metal ion binding//oxidoreductase activity//ferric iron binding -- -- -- -- Cluster-8309.36194 BF_2 4615.50 21.47 9279 270015028 EFA11476.1 1443 2.9e-156 hypothetical protein TcasGA2_TC014187 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q70PU1 454 5.6e-43 Peptidoglycan-recognition protein SC2 OS=Drosophila simulans GN=PGRP-SC2 PE=3 SV=1 PF00620//PF01510//PF01365//PF03740//PF04840 RhoGAP domain//N-acetylmuramoyl-L-alanine amidase//RIH domain//Pyridoxal phosphate biosynthesis protein PdxJ//Vps16, C-terminal region GO:0070588//GO:0009253//GO:0006886//GO:0007165//GO:0006816//GO:0006807//GO:0009252//GO:0008615 calcium ion transmembrane transport//peptidoglycan catabolic process//intracellular protein transport//signal transduction//calcium ion transport//nitrogen compound metabolic process//peptidoglycan biosynthetic process//pyridoxine biosynthetic process GO:0005262//GO:0033856//GO:0008745 calcium channel activity//pyridoxine 5'-phosphate synthase activity//N-acetylmuramoyl-L-alanine amidase activity GO:0005737//GO:0016020 cytoplasm//membrane -- -- Cluster-8309.36195 BF_2 2658.02 37.71 3236 642913109 XP_008201396.1 2378 3.8e-265 PREDICTED: protein GDAP2 homolog [Tribolium castaneum] 801371847 XM_012207242.1 186 5.88023e-90 PREDICTED: Atta cephalotes protein GDAP2 homolog (LOC105625932), mRNA -- -- -- -- Q7JUR6 1430 1.3e-156 Protein GDAP2 homolog OS=Drosophila melanogaster GN=CG18812 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2633 Hismacro and SEC14 domain-containing proteins Cluster-8309.36197 BF_2 1510.01 15.09 4474 642920299 XP_008192288.1 1517 3.6e-165 PREDICTED: interferon regulatory factor 2-binding protein 2 isoform X2 [Tribolium castaneum] 642920300 XM_008194067.1 94 1.13227e-38 PREDICTED: Tribolium castaneum interferon regulatory factor 2-binding protein 2 (LOC664517), transcript variant X3, mRNA -- -- -- -- E9Q1P8 403 2.2e-37 Interferon regulatory factor 2-binding protein 2 OS=Mus musculus GN=Irf2bp2 PE=1 SV=1 PF00097//PF02778 Zinc finger, C3HC4 type (RING finger)//tRNA intron endonuclease, N-terminal domain GO:0006388//GO:0051252 tRNA splicing, via endonucleolytic cleavage and ligation//regulation of RNA metabolic process GO:0000213//GO:0046872 tRNA-intron endonuclease activity//metal ion binding GO:0000214 tRNA-intron endonuclease complex KOG3579 Predicted E3 ubiquitin ligase Cluster-8309.36198 BF_2 830.91 8.71 4279 665814511 XP_008555868.1 4780 0.0e+00 PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor]>gi|665814513|ref|XP_008555869.1| PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor] 749751938 XM_011139992.1 608 0 PREDICTED: Harpegnathos saltator regulator of nonsense transcripts 1 (LOC105182511), transcript variant X4, mRNA K14326 UPF1, RENT1 regulator of nonsense transcripts 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14326 Q9EPU0 3940 0.0e+00 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 PF00270//PF00580//PF04851//PF00004//PF00437//PF09416//PF00448//PF07728 DEAD/DEAH box helicase//UvrD/REP helicase N-terminal domain//Type III restriction enzyme, res subunit//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//RNA helicase (UPF2 interacting domain)//SRP54-type protein, GTPase domain//AAA domain (dynein-related subfamily) GO:0000184//GO:0006810//GO:0006614 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//transport//SRP-dependent cotranslational protein targeting to membrane GO:0003677//GO:0016787//GO:0004386//GO:0005524//GO:0016887//GO:0003676//GO:0008270//GO:0005525 DNA binding//hydrolase activity//helicase activity//ATP binding//ATPase activity//nucleic acid binding//zinc ion binding//GTP binding GO:0005737 cytoplasm KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.36199 BF_2 941.93 7.99 5216 58294539 AAW70172.1 3429 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1244 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2319 1.7e-259 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36200 BF_2 5154.58 146.40 1760 642927566 XP_972340.2 667 5.2e-67 PREDICTED: 40S ribosomal protein S12 [Tribolium castaneum] -- -- -- -- -- K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P80455 492 4.2e-48 40S ribosomal protein S12 OS=Drosophila melanogaster GN=RpS12 PE=1 SV=2 PF02065 Melibiase GO:0006012//GO:0001575//GO:0046486//GO:0005975 galactose metabolic process//globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0004557 alpha-galactosidase activity -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.36201 BF_2 3708.00 118.06 1601 478258005 ENN78143.1 1332 3.7e-144 hypothetical protein YQE_05297, partial [Dendroctonus ponderosae] 543739188 XM_005510443.1 149 1.06502e-69 PREDICTED: Columba livia adenosine monophosphate deaminase 2 (AMPD2), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 1077 5.6e-116 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00962 Adenosine/AMP deaminase -- -- GO:0019239 deaminase activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.36202 BF_2 1049.32 9.70 4812 147902182 NP_001079763.1 447 4.6e-41 ER lumen protein-retaining receptor 3 [Xenopus laevis]>gi|6685399|sp|O42580.1|ERD23_XENLA RecName: Full=ER lumen protein-retaining receptor 3; AltName: Full=KDEL endoplasmic reticulum protein retention receptor 3; Short=KDEL receptor 3 [Xenopus laevis]>gi|2467290|emb|CAA04817.1| KDEL receptor [Xenopus laevis]>gi|32450093|gb|AAH54181.1| MGC64313 protein [Xenopus laevis] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 Q66JF2 456 1.7e-43 ER lumen protein-retaining receptor 3 OS=Xenopus tropicalis GN=kdelr3 PE=2 SV=1 PF00810//PF05297 ER lumen protein retaining receptor//Herpesvirus latent membrane protein 1 (LMP1) GO:0006621//GO:0019087 protein retention in ER lumen//transformation of host cell by virus GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG3106 ER lumen protein retaining receptor Cluster-8309.36203 BF_2 290.03 1.55 8093 642932804 XP_008196990.1 7075 0.0e+00 PREDICTED: myosin heavy chain, non-muscle isoform X1 [Tribolium castaneum] 462326123 APGK01041549.1 824 0 Dendroctonus ponderosae Seq01041559, whole genome shotgun sequence K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 5949 0.0e+00 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF00063//PF00612//PF01576//PF08471 Myosin head (motor domain)//IQ calmodulin-binding motif//Myosin tail//Class II vitamin B12-dependent ribonucleotide reductase GO:0006206//GO:0055114//GO:0009186//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0003774//GO:0050897//GO:0005524//GO:0005515//GO:0004748 motor activity//cobalt ion binding//ATP binding//protein binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0016459//GO:0005971 myosin complex//ribonucleoside-diphosphate reductase complex KOG0161 Myosin class II heavy chain Cluster-8309.36204 BF_2 410.44 6.85 2792 189240077 XP_971167.2 1708 1.6e-187 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 190 6.9e-13 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF13414//PF00856 TPR repeat//SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.36205 BF_2 1897.00 32.25 2748 546683090 ERL92945.1 1119 3.1e-119 hypothetical protein D910_10250, partial [Dendroctonus ponderosae] -- -- -- -- -- K09522 DNAJC2 DnaJ homolog subfamily C member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09522 Q1RMH9 666 4.4e-68 DnaJ homolog subfamily C member 2 OS=Bos taurus GN=DNAJC2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0724 Zuotin and related molecular chaperones (DnaJ superfamily), contains DNA-binding domains Cluster-8309.36207 BF_2 94.89 1.02 4169 642911951 XP_008199035.1 2062 2.1e-228 PREDICTED: GPI ethanolamine phosphate transferase 1 isoform X1 [Tribolium castaneum] 815881985 XM_001241521.2 35 6.62136e-06 Coccidioides immitis RS GPI ethanolamine phosphate transferase 1 mRNA K05285 PIGN phosphatidylinositol glycan, class N http://www.genome.jp/dbget-bin/www_bget?ko:K05285 Q9R1S3 1386 2.1e-151 GPI ethanolamine phosphate transferase 1 OS=Mus musculus GN=Pign PE=2 SV=2 PF02563//PF04987//PF01676//PF00884//PF01663 Polysaccharide biosynthesis/export protein//Phosphatidylinositolglycan class N (PIG-N)//Metalloenzyme superfamily//Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0006506//GO:0008152//GO:0015774 GPI anchor biosynthetic process//metabolic process//polysaccharide transport GO:0008484//GO:0046872//GO:0016740//GO:0003824//GO:0015159 sulfuric ester hydrolase activity//metal ion binding//transferase activity//catalytic activity//polysaccharide transmembrane transporter activity GO:0016020//GO:0005789 membrane//endoplasmic reticulum membrane KOG2124 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.36208 BF_2 3915.39 60.31 3003 642936134 XP_008198313.1 3418 0.0e+00 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 722 0 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q8T674 926 3.4e-98 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF00005//PF03193//PF01061//PF13304 ABC transporter//Protein of unknown function, DUF258//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0003924//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ATP binding//GTP binding//ATPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.36209 BF_2 1441.16 157.06 671 478259615 ENN79468.1 186 1.2e-11 hypothetical protein YQE_04112, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36210 BF_2 12804.17 69.12 8036 642913015 XP_008201353.1 11416 0.0e+00 PREDICTED: spectrin alpha chain [Tribolium castaneum]>gi|270002786|gb|EEZ99233.1| alpha spectrin [Tribolium castaneum] 158296318 XM_316724.4 2095 0 Anopheles gambiae str. PEST AGAP006686-PA (AgaP_AGAP006686) mRNA, complete cds K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 10164 0.0e+00 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF00435//PF13499//PF13405//PF13833//PF13202//PF14604//PF00018//PF00036 Spectrin repeat//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Variant SH3 domain//SH3 domain//EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36211 BF_2 1693.31 40.50 2036 91087493 XP_968456.1 1243 9.7e-134 PREDICTED: proteasome subunit alpha type-4 [Tribolium castaneum]>gi|270009464|gb|EFA05912.1| hypothetical protein TcasGA2_TC008727 [Tribolium castaneum] 766941897 XM_011505296.1 228 1.6518e-113 PREDICTED: Ceratosolen solmsi marchali proteasome subunit alpha type-4 (LOC105366753), transcript variant X3, mRNA K02728 PSMA4 20S proteasome subunit alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02728 P21670 1079 4.2e-116 Proteasome subunit alpha type-4 OS=Rattus norvegicus GN=Psma4 PE=1 SV=1 PF10584//PF08465//PF00227 Proteasome subunit A N-terminal signature//Thymidine kinase from Herpesvirus C-terminal//Proteasome subunit GO:0051603//GO:0006206//GO:0006511//GO:0006230 proteolysis involved in cellular protein catabolic process//pyrimidine nucleobase metabolic process//ubiquitin-dependent protein catabolic process//TMP biosynthetic process GO:0004298//GO:0004175//GO:0004797//GO:0005524 threonine-type endopeptidase activity//endopeptidase activity//thymidine kinase activity//ATP binding GO:0019773//GO:0005737//GO:0005839//GO:0005634 proteasome core complex, alpha-subunit complex//cytoplasm//proteasome core complex//nucleus KOG0178 20S proteasome, regulatory subunit alpha type PSMA4/PRE9 Cluster-8309.36212 BF_2 863.71 20.94 2013 478252723 ENN73118.1 1681 1.6e-184 hypothetical protein YQE_10259, partial [Dendroctonus ponderosae] 157136796 XM_001656862.1 215 2.75167e-106 Aedes aegypti AAEL003514-RA mRNA K11131 DKC1, NOLA4, CBF5 H/ACA ribonucleoprotein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11131 O44081 1625 2.0e-179 H/ACA ribonucleoprotein complex subunit 4 OS=Drosophila melanogaster GN=Nop60B PE=1 SV=1 PF01509//PF01472 TruB family pseudouridylate synthase (N terminal domain)//PUA domain GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG2529 Pseudouridine synthase Cluster-8309.36213 BF_2 36769.06 956.65 1895 291170322 ADD82417.1 210 5.5e-14 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27017 155 5.4e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36215 BF_2 15.00 1.61 678 642912272 XP_008200632.1 235 2.5e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01833 IPT/TIG domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36216 BF_2 52.52 1.02 2434 134131322 BAF49604.1 1050 2.8e-111 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 531 1.7e-52 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF00089 Glycosyl hydrolases family 18//Trypsin GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004252 hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type endopeptidase activity -- -- KOG2806 Chitinase Cluster-8309.36217 BF_2 4537.22 127.14 1780 332372941 AEE61612.1 1837 1.1e-202 unknown [Dendroctonus ponderosae] 642917730 XM_008193127.1 333 6.15639e-172 PREDICTED: Tribolium castaneum glutamine synthetase 2 cytoplasmic (LOC656087), transcript variant X4, mRNA K01915 glnA, GLUL glutamine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01915 P20478 1509 5.0e-166 Glutamine synthetase 2 cytoplasmic OS=Drosophila melanogaster GN=Gs2 PE=2 SV=3 PF00120//PF01844//PF03951 Glutamine synthetase, catalytic domain//HNH endonuclease//Glutamine synthetase, beta-Grasp domain GO:0006807//GO:0009252//GO:0006542 nitrogen compound metabolic process//peptidoglycan biosynthetic process//glutamine biosynthetic process GO:0004356//GO:0004519//GO:0003676 glutamate-ammonia ligase activity//endonuclease activity//nucleic acid binding -- -- KOG0683 Glutamine synthetase Cluster-8309.36219 BF_2 1554.15 24.69 2920 642929416 XP_008195830.1 1110 3.7e-118 PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929418|ref|XP_008195831.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum]>gi|642929420|ref|XP_008195832.1| PREDICTED: transcription factor CP2-like protein 1 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q811S7 662 1.3e-67 Upstream-binding protein 1 OS=Mus musculus GN=Ubp1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.36221 BF_2 971.97 17.60 2597 642911404 XP_008199408.1 893 4.8e-93 PREDICTED: uncharacterized protein LOC100142456 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GM59 233 6.7e-18 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.36222 BF_2 122.00 1.48 3727 642910934 XP_008193472.1 1263 8.5e-136 PREDICTED: probable serine/threonine-protein kinase kinX [Tribolium castaneum]>gi|270014958|gb|EFA11406.1| hypothetical protein TcasGA2_TC013580 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.36224 BF_2 8737.95 269.40 1644 91076986 XP_975465.1 1098 5.1e-117 PREDICTED: SPARC [Tribolium castaneum]>gi|270001994|gb|EEZ98441.1| hypothetical protein TcasGA2_TC000930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34714 555 1.9e-55 SPARC OS=Caenorhabditis elegans GN=ost-1 PE=1 SV=1 PF00713//PF09289//PF07648//PF10591 Hirudin//Follistatin/Osteonectin-like EGF domain//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region GO:0007165 signal transduction GO:0005509//GO:0005515//GO:0004867 calcium ion binding//protein binding//serine-type endopeptidase inhibitor activity GO:0005578//GO:0005615 proteinaceous extracellular matrix//extracellular space KOG4004 Matricellular protein Osteonectin/SPARC/BM-40 Cluster-8309.36226 BF_2 1047.00 82.98 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36227 BF_2 88482.18 1803.95 2339 642935904 XP_008198222.1 2533 2.9e-283 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X2 [Tribolium castaneum]>gi|270013982|gb|EFA10430.1| hypothetical protein TcasGA2_TC012671 [Tribolium castaneum] 170066649 XM_001868153.1 669 0 Culex quinquefasciatus calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2374 3.3e-266 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 -- -- GO:0006816//GO:0006754 calcium ion transport//ATP biosynthetic process GO:0005388//GO:0005524//GO:0046872 calcium-transporting ATPase activity//ATP binding//metal ion binding GO:0016021//GO:0016529 integral component of membrane//sarcoplasmic reticulum KOG0202 Ca2+ transporting ATPase Cluster-8309.36228 BF_2 5112.07 84.40 2821 332374576 AEE62429.1 1472 3.8e-160 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 295 1.30708e-150 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1258 1.0e-136 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191//PF00152 Annexin//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0005509//GO:0005524//GO:0000166//GO:0005544//GO:0004812 calcium ion binding//ATP binding//nucleotide binding//calcium-dependent phospholipid binding//aminoacyl-tRNA ligase activity -- -- -- -- Cluster-8309.36229 BF_2 6589.83 759.71 650 264667337 ACY71254.1 881 2.9e-92 ribosomal protein L11 [Chrysomela tremula] 242380639 FP096472.1 206 8.63295e-102 Phyllostachys edulis cDNA clone: bphylf002j10, full insert sequence K02868 RP-L11e, RPL11 large subunit ribosomal protein L11e http://www.genome.jp/dbget-bin/www_bget?ko:K02868 P46222 822 8.4e-87 60S ribosomal protein L11 OS=Drosophila melanogaster GN=RpL11 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0397 60S ribosomal protein L11 Cluster-8309.36230 BF_2 3067.26 28.37 4810 189240719 XP_974316.2 3717 0.0e+00 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] 640785773 XM_008050426.1 160 2.49142e-75 PREDICTED: Tarsius syrichta TBC1 domain family, member 9B (with GRAM domain) (TBC1D9B), transcript variant X2, mRNA -- -- -- -- Q6ZT07 2407 1.0e-269 TBC1 domain family member 9 OS=Homo sapiens GN=TBC1D9 PE=2 SV=2 PF13499//PF13833//PF00036//PF13405//PF10637//PF04840//PF13202 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Oxoglutarate and iron-dependent oxygenase degradation C-term//Vps16, C-terminal region//EF hand GO:0006886//GO:0055114 intracellular protein transport//oxidation-reduction process GO:0016706//GO:0031418//GO:0005509//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//L-ascorbic acid binding//calcium ion binding//iron ion binding GO:0005737 cytoplasm KOG4347 GTPase-activating protein VRP Cluster-8309.36231 BF_2 5434.00 963.43 523 264667453 ACY71312.1 407 2.2e-37 ribosomal protein L35 [Chrysomela tremula] 197260765 EU930255.1 75 4.55393e-29 Simulium vittatum clone SV-271 60S ribosomal protein L35 mRNA, complete cds K02918 RP-L35e, RPL35 large subunit ribosomal protein L35e http://www.genome.jp/dbget-bin/www_bget?ko:K02918 Q69CJ9 276 1.4e-23 60S ribosomal protein L35 OS=Ophiophagus hannah GN=RPL35 PE=2 SV=3 PF00831 Ribosomal L29 protein GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3436 60S ribosomal protein L35 Cluster-8309.36232 BF_2 886.05 34.45 1363 332373426 AEE61854.1 1251 7.7e-135 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14012 SHP1, UBX1, NSFL1C UBX domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14012 Q5ZK10 727 1.8e-75 NSFL1 cofactor p47 OS=Gallus gallus GN=NSFL1C PE=2 SV=1 PF00789 UBX domain -- -- GO:0005515 protein binding -- -- KOG2086 Protein tyrosine phosphatase SHP1/Cofactor for p97 ATPase-mediated vesicle membrane fusion Cluster-8309.36233 BF_2 15360.66 891.43 1008 546680237 ERL90555.1 690 6.4e-70 hypothetical protein D910_07903 [Dendroctonus ponderosae] 332373055 BT126707.1 106 5.30678e-46 Dendroctonus ponderosae clone DPO131_P13 unknown mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47947 433 1.7e-41 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF12763//PF13202//PF13499//PF00036//PF13833//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.36234 BF_2 300.17 2.66 5011 91085385 XP_966386.1 455 5.7e-42 PREDICTED: arginine/serine-rich coiled-coil protein 2 [Tribolium castaneum]>gi|270009149|gb|EFA05597.1| hypothetical protein TcasGA2_TC015801 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHJ5 200 8.6e-14 Arginine/serine-rich coiled-coil protein 2 OS=Xenopus tropicalis GN=rsrc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36235 BF_2 12655.43 881.12 888 264667427 ACY71299.1 985 3.5e-104 ribosomal protein L7A [Chrysomela tremula] 264667426 GU120449.1 275 5.26196e-140 Chrysomela tremulae ribosomal protein L7A (RpL7A) mRNA, complete cds K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P46223 854 2.2e-90 60S ribosomal protein L7a OS=Drosophila melanogaster GN=RpL7A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8309.36236 BF_2 458.95 5.74 3633 642923738 XP_008193865.1 3045 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X7 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 Q9QUJ7 1680 1.5e-185 Long-chain-fatty-acid--CoA ligase 4 OS=Mus musculus GN=Acsl4 PE=2 SV=2 PF00908//PF00501 dTDP-4-dehydrorhamnose 3,5-epimerase//AMP-binding enzyme GO:0009117//GO:0019872//GO:0008152//GO:0030639 nucleotide metabolic process//streptomycin biosynthetic process//metabolic process//polyketide biosynthetic process GO:0003824//GO:0008830 catalytic activity//dTDP-4-dehydrorhamnose 3,5-epimerase activity -- -- KOG1180 Acyl-CoA synthetase Cluster-8309.36238 BF_2 1213.00 16.78 3311 642917356 XP_008199268.1 4321 0.0e+00 PREDICTED: superkiller viralicidic activity 2-like 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12598 MTR4, SKIV2L2 ATP-dependent RNA helicase DOB1 http://www.genome.jp/dbget-bin/www_bget?ko:K12598 Q9CZU3 3161 0.0e+00 Superkiller viralicidic activity 2-like 2 OS=Mus musculus GN=Skiv2l2 PE=1 SV=1 PF00437//PF00270 Type II/IV secretion system protein//DEAD/DEAH box helicase GO:0006810 transport GO:0003676//GO:0005524 nucleic acid binding//ATP binding -- -- KOG0948 Nuclear exosomal RNA helicase MTR4, DEAD-box superfamily Cluster-8309.36239 BF_2 141.21 2.05 3172 91089165 XP_973951.1 493 1.4e-46 PREDICTED: H/ACA ribonucleoprotein complex non-core subunit NAF1 [Tribolium castaneum]>gi|270011488|gb|EFA07936.1| hypothetical protein TcasGA2_TC005517 [Tribolium castaneum] -- -- -- -- -- K14763 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 http://www.genome.jp/dbget-bin/www_bget?ko:K14763 Q9VJ62 316 1.9e-27 H/ACA ribonucleoprotein complex non-core subunit NAF1 OS=Drosophila melanogaster GN=CG10341 PE=1 SV=2 PF03153//PF04889//PF04410//PF04931 Transcription factor IIA, alpha/beta subunit//Cwf15/Cwc15 cell cycle control protein//Gar1/Naf1 RNA binding region//DNA polymerase phi GO:0006351//GO:0006260//GO:0042254//GO:0001522//GO:0006367//GO:0000398 transcription, DNA-templated//DNA replication//ribosome biogenesis//pseudouridine synthesis//transcription initiation from RNA polymerase II promoter//mRNA splicing, via spliceosome GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0005681//GO:0042575//GO:0005672 spliceosomal complex//DNA polymerase complex//transcription factor TFIIA complex KOG2236 Uncharacterized conserved protein Cluster-8309.3624 BF_2 6.00 0.62 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.36241 BF_2 112.00 0.89 5528 642926415 XP_008191953.1 2954 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X2 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.64162e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 4.1e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.36242 BF_2 175.08 1.34 5746 646705667 KDR13254.1 634 1.1e-62 hypothetical protein L798_12642, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8N184 499 2.1e-48 Zinc finger protein 567 OS=Homo sapiens GN=ZNF567 PE=1 SV=3 PF00096//PF07664//PF07776//PF13465//PF00412//PF13912//PF00122//PF05191//PF16622//PF00320 Zinc finger, C2H2 type//Ferrous iron transport protein B C terminus//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//LIM domain//C2H2-type zinc finger//E1-E2 ATPase//Adenylate kinase, active site lid//zinc-finger C2H2-type//GATA zinc finger GO:0015684//GO:0006355//GO:0046034//GO:0006144 ferrous iron transport//regulation of transcription, DNA-templated//ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017//GO:0003700//GO:0008270//GO:0000166//GO:0043565//GO:0015093 metal ion binding//adenylate kinase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//nucleotide binding//sequence-specific DNA binding//ferrous iron transmembrane transporter activity GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus -- -- Cluster-8309.36244 BF_2 281.89 29.34 689 478250947 ENN71431.1 294 3.6e-24 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7X3Z4 148 1.3e-08 C-type lectin lectoxin-Lio1 OS=Erythrolamprus poecilogyrus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36246 BF_2 5.77 0.38 918 91084673 XP_968064.1 758 7.6e-78 PREDICTED: 40S ribosomal protein S3a [Tribolium castaneum]>gi|270008925|gb|EFA05373.1| hypothetical protein TcasGA2_TC015539 [Tribolium castaneum] 755939307 XM_011299427.1 162 3.56858e-77 PREDICTED: Fopius arisanus 40S ribosomal protein S3a (LOC105263301), mRNA K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 Q5G5C4 743 1.7e-77 40S ribosomal protein S3a OS=Periplaneta americana GN=Parcxpwex01 PE=2 SV=1 PF01015//PF04083 Ribosomal S3Ae family//Partial alpha/beta-hydrolase lipase region GO:0042254//GO:0006412//GO:0006629 ribosome biogenesis//translation//lipid metabolic process GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1628 40S ribosomal protein S3A Cluster-8309.36247 BF_2 9.92 0.33 1550 91076380 XP_968185.1 1749 1.6e-192 PREDICTED: interleukin enhancer-binding factor 2 homolog [Tribolium castaneum]>gi|270002554|gb|EEZ99001.1| hypothetical protein TcasGA2_TC004865 [Tribolium castaneum] 332373637 BT126998.1 276 2.59459e-140 Dendroctonus ponderosae clone DPO1124_K05 unknown mRNA K13089 ILF2 interleukin enhancer-binding factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13089 Q9VG73 1299 9.8e-142 Interleukin enhancer-binding factor 2 homolog OS=Drosophila melanogaster GN=CG5641 PE=2 SV=1 -- -- GO:0006955 immune response GO:0016740//GO:0003723//GO:0005524 transferase activity//RNA binding//ATP binding -- -- KOG3793 Transcription factor NFAT, subunit NF45 Cluster-8309.36248 BF_2 517719.00 2338.84 9547 478263038 ENN81438.1 8441 0.0e+00 hypothetical protein YQE_02131, partial [Dendroctonus ponderosae] 462389649 APGK01019091.1 63 4.14583e-21 Dendroctonus ponderosae Seq01019101, whole genome shotgun sequence -- -- -- -- Q9U943 3480 0.0e+00 Apolipophorins OS=Locusta migratoria PE=1 SV=2 PF01442//PF01347//PF02949//PF09172//PF09074//PF06448//PF08702//PF04513 Apolipoprotein A1/A4/E domain//Lipoprotein amino terminal region//7tm Odorant receptor//Domain of unknown function (DUF1943)//Mer2//Domain of Unknown Function (DUF1081)//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007131//GO:0051258//GO:0007165//GO:0007187//GO:0007608//GO:0030168//GO:0006869//GO:0042157 reciprocal meiotic recombination//protein polymerization//signal transduction//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell//platelet activation//lipid transport//lipoprotein metabolic process GO:0005102//GO:0005549//GO:0005198//GO:0004984//GO:0030674//GO:0005319//GO:0008289 receptor binding//odorant binding//structural molecule activity//olfactory receptor activity//protein binding, bridging//lipid transporter activity//lipid binding GO:0005577//GO:0019028//GO:0016020//GO:0005576//GO:0019031//GO:0000794 fibrinogen complex//viral capsid//membrane//extracellular region//viral envelope//condensed nuclear chromosome -- -- Cluster-8309.36249 BF_2 485.47 3.81 5623 642915997 XP_008190849.1 4186 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 401 0 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 1237 5.5e-134 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF07714//PF00069//PF06293//PF00041//PF13895//PF16656 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0006468//GO:0019497 riboflavin metabolic process//protein phosphorylation//hexachlorocyclohexane metabolic process GO:0004672//GO:0046872//GO:0016773//GO:0003993//GO:0005515//GO:0005524 protein kinase activity//metal ion binding//phosphotransferase activity, alcohol group as acceptor//acid phosphatase activity//protein binding//ATP binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36250 BF_2 12471.00 561.06 1217 589060796 AHK26791.1 1474 9.5e-161 eukaryotic translation initiation factor 4A [Epicauta chinensis] 817197946 XM_012419174.1 283 2.60013e-144 PREDICTED: Orussus abietinus eukaryotic initiation factor 4A-I (LOC105696595), mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q5R4X1 1171 5.3e-127 Eukaryotic initiation factor 4A-II OS=Pongo abelii GN=EIF4A2 PE=2 SV=1 PF04851//PF07652//PF00270 Type III restriction enzyme, res subunit//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0019079 viral genome replication GO:0005524//GO:0003676//GO:0003677//GO:0016787//GO:0008026 ATP binding//nucleic acid binding//DNA binding//hydrolase activity//ATP-dependent helicase activity -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.36252 BF_2 474.02 3.08 6735 189237751 XP_001812575.1 2460 2.4e-274 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 9.9e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF04769//PF00787//PF08070 Mating-type protein MAT alpha 1 HMG-box//PX domain//DTHCT (NUC029) region GO:0006265//GO:0045895//GO:0007531 DNA topological change//positive regulation of mating-type specific transcription, DNA-templated//mating type determination GO:0008301//GO:0003918//GO:0035091//GO:0003677//GO:0005524 DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity//phosphatidylinositol binding//DNA binding//ATP binding GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.36255 BF_2 775.88 7.81 4443 91094823 XP_971065.1 3125 0.0e+00 PREDICTED: protein O-mannosyltransferase 1 [Tribolium castaneum] 847169839 XM_002938748.3 97 2.41666e-40 PREDICTED: Xenopus (Silurana) tropicalis proteasome (prosome, macropain) subunit, beta type, 7 (psmb7), mRNA K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q9VTK2 2264 3.5e-253 Protein O-mannosyltransferase 1 OS=Drosophila melanogaster GN=rt PE=2 SV=2 PF02366//PF02815//PF00227 Dolichyl-phosphate-mannose-protein mannosyltransferase//MIR domain//Proteasome subunit GO:0051603//GO:0006493 proteolysis involved in cellular protein catabolic process//protein O-linked glycosylation GO:0004298//GO:0000030 threonine-type endopeptidase activity//mannosyltransferase activity GO:0000136//GO:0016020//GO:0005839 alpha-1,6-mannosyltransferase complex//membrane//proteasome core complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.36256 BF_2 62.61 0.98 2960 264667471 ACY71321.1 794 1.6e-81 ribosomal biogenesis protein RLP24 [Chrysomela tremula] -- -- -- -- -- K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q9VGN9 595 8.0e-60 Probable ribosome biogenesis protein RLP24 OS=Drosophila melanogaster GN=RpL24-like PE=1 SV=1 PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1723 60s ribosomal protein L30 isolog Cluster-8309.36257 BF_2 4516.96 23.65 8276 642920909 XP_008192611.1 8856 0.0e+00 PREDICTED: spectrin beta chain isoform X5 [Tribolium castaneum] 642920908 XM_008194389.1 1881 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7554 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00307//PF00435//PF04728 Calponin homology (CH) domain//Spectrin repeat//Lipoprotein leucine-zipper -- -- GO:0005515 protein binding GO:0019867 outer membrane KOG0517 Beta-spectrin Cluster-8309.36260 BF_2 1192.00 65.03 1054 642934887 XP_008197848.1 1167 3.3e-125 PREDICTED: eukaryotic translation initiation factor 3 subunit G [Tribolium castaneum]>gi|270013801|gb|EFA10249.1| hypothetical protein TcasGA2_TC012449 [Tribolium castaneum] -- -- -- -- -- K03248 EIF3G translation initiation factor 3 subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K03248 Q1HQN4 820 2.3e-86 Eukaryotic translation initiation factor 3 subunit G OS=Aedes aegypti GN=eIF3-S4-1 PE=2 SV=1 PF06220//PF00076 U1 zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003676//GO:0000166//GO:0008270 translation initiation factor activity//nucleic acid binding//nucleotide binding//zinc ion binding GO:0005840//GO:0005737 ribosome//cytoplasm KOG0122 Translation initiation factor 3, subunit g (eIF-3g) Cluster-8309.36263 BF_2 82.52 1.03 3649 73921486 AAZ94273.1 1713 5.5e-188 cytochrome P450 [Leptinotarsa decemlineata] 73921485 DQ117464.1 318 2.7779e-163 Leptinotarsa decemlineata cytochrome P450 (CYP4G29) mRNA, complete cds K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 Q9VYY4 1319 1.1e-143 Cytochrome P450 4g15 OS=Drosophila melanogaster GN=Cyp4g15 PE=2 SV=1 PF00067//PF00762 Cytochrome P450//Ferrochelatase GO:0006783//GO:0055114//GO:0015994 heme biosynthetic process//oxidation-reduction process//chlorophyll metabolic process GO:0004325//GO:0016705//GO:0020037//GO:0005506 ferrochelatase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.36265 BF_2 436.31 20.63 1172 91079867 XP_967070.1 1136 1.4e-121 PREDICTED: purine nucleoside phosphorylase isoform X2 [Tribolium castaneum]>gi|270004553|gb|EFA01001.1| hypothetical protein TcasGA2_TC003914 [Tribolium castaneum] 327297537 XM_003233415.1 34 6.55353e-06 Trichophyton rubrum CBS 118892 purine nucleoside phosphorylase (TERG_06452) mRNA, complete cds K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P55859 777 2.5e-81 Purine nucleoside phosphorylase OS=Bos taurus GN=PNP PE=1 SV=3 PF01048 Phosphorylase superfamily GO:0006144//GO:0006769//GO:0046497//GO:0009116//GO:0006206 purine nucleobase metabolic process//nicotinamide metabolic process//nicotinate nucleotide metabolic process//nucleoside metabolic process//pyrimidine nucleobase metabolic process GO:0004731//GO:0003824 purine-nucleoside phosphorylase activity//catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.36266 BF_2 634.00 19.82 1625 642917962 XP_008198961.1 790 2.6e-81 PREDICTED: probable phospholipid hydroperoxide glutathione peroxidase [Tribolium castaneum]>gi|270004924|gb|EFA01372.1| hypothetical protein TcasGA2_TC010362 [Tribolium castaneum] -- -- -- -- -- K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q9N2J2 503 2.0e-49 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Bos taurus GN=GPX4 PE=2 SV=2 PF00255//PF00578//PF08534 Glutathione peroxidase//AhpC/TSA family//Redoxin GO:0006979//GO:0055114//GO:0006804//GO:0006749 response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction//glutathione metabolic process GO:0016491//GO:0016209//GO:0004602 oxidoreductase activity//antioxidant activity//glutathione peroxidase activity -- -- KOG1651 Glutathione peroxidase Cluster-8309.36267 BF_2 797.00 65.39 797 167444218 ABZ80670.1 471 1.3e-44 i-type lysozyme [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.36268 BF_2 198.96 5.34 1847 642912944 XP_008201318.1 854 1.1e-88 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 539 1.6e-53 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36269 BF_2 2550.80 47.36 2540 642938577 XP_008199848.1 2844 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938579|ref|XP_008199849.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938581|ref|XP_008199850.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938583|ref|XP_008199851.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938585|ref|XP_008199852.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|270015602|gb|EFA12050.1| hypothetical protein TcasGA2_TC001467 [Tribolium castaneum] 642938584 XM_008201630.1 746 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X5, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 Q16720 1872 5.8e-208 Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens GN=ATP2B3 PE=1 SV=3 PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006754//GO:0070588//GO:0006816 ATP biosynthetic process//calcium ion transmembrane transport//calcium ion transport GO:0046872//GO:0005388//GO:0005524 metal ion binding//calcium-transporting ATPase activity//ATP binding GO:0016529//GO:0016021 sarcoplasmic reticulum//integral component of membrane KOG0204 Calcium transporting ATPase Cluster-8309.36270 BF_2 749.00 81.84 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05790 Immunoglobulin C2-set domain GO:0007155 cell adhesion -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36273 BF_2 875.66 6.79 5682 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 6.20008e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF05201//PF03178 Glutamyl-tRNAGlu reductase, N-terminal domain//CPSF A subunit region GO:0055114//GO:0033014 oxidation-reduction process//tetrapyrrole biosynthetic process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.36275 BF_2 4780.50 129.37 1833 642927717 XP_008195380.1 1020 6.3e-108 PREDICTED: ras-like GTP-binding protein Rho1 isoform X1 [Tribolium castaneum] 755932870 XM_011316165.1 162 7.25599e-77 PREDICTED: Fopius arisanus ras-like GTP-binding protein Rho1 (LOC105273622), transcript variant X9, mRNA K04513 RHOA Ras homolog gene family, member A http://www.genome.jp/dbget-bin/www_bget?ko:K04513 P48148 946 9.9e-101 Ras-like GTP-binding protein Rho1 OS=Drosophila melanogaster GN=Rho1 PE=1 SV=1 PF08477//PF00025//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.36276 BF_2 964.26 49.08 1109 121582324 NP_001073566.1 1159 2.9e-124 cuticular protein analogous to peritrophins 3-B precursor [Tribolium castaneum]>gi|119387886|gb|ABL73928.1| obstractor B [Tribolium castaneum]>gi|270000881|gb|EEZ97328.1| hypothetical protein TcasGA2_TC011139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W5U2 149 1.6e-08 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.36277 BF_2 1046.09 12.43 3807 91082911 XP_972477.1 4248 0.0e+00 PREDICTED: FACT complex subunit spt16 [Tribolium castaneum]>gi|270007613|gb|EFA04061.1| hypothetical protein TcasGA2_TC014294 [Tribolium castaneum] 817053620 XM_012407564.1 485 0 PREDICTED: Athalia rosae FACT complex subunit spt16 (LOC105690057), transcript variant X2, mRNA -- -- -- -- Q8IRG6 3463 0.0e+00 FACT complex subunit spt16 OS=Drosophila melanogaster GN=dre4 PE=1 SV=2 PF02499 Probable DNA packing protein, C-terminus GO:0006323//GO:0009987 DNA packaging//cellular process -- -- -- -- KOG1189 Global transcriptional regulator, cell division control protein Cluster-8309.36278 BF_2 400.00 23.09 1012 332374942 AEE62612.1 738 1.7e-75 unknown [Dendroctonus ponderosae]>gi|546684327|gb|ERL94032.1| hypothetical protein D910_11315 [Dendroctonus ponderosae] -- -- -- -- -- K03687 GRPE molecular chaperone GrpE http://www.genome.jp/dbget-bin/www_bget?ko:K03687 Q99LP6 518 2.3e-51 GrpE protein homolog 1, mitochondrial OS=Mus musculus GN=Grpel1 PE=1 SV=1 PF01025//PF08996//PF06156 GrpE//DNA Polymerase alpha zinc finger//Protein of unknown function (DUF972) GO:0006260//GO:0006457 DNA replication//protein folding GO:0001882//GO:0051087//GO:0042803//GO:0000774//GO:0003887 nucleoside binding//chaperone binding//protein homodimerization activity//adenyl-nucleotide exchange factor activity//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG3003 Molecular chaperone of the GrpE family Cluster-8309.36279 BF_2 9041.98 780.15 772 91079322 XP_968042.1 717 3.6e-73 PREDICTED: 60S ribosomal protein L18 [Tribolium castaneum]>gi|270004338|gb|EFA00786.1| hypothetical protein TcasGA2_TC003672 [Tribolium castaneum] 70909738 AM049056.1 269 9.843e-137 Timarcha balearica mRNA for ribosomal protein L18e (rpL18e gene) K02883 RP-L18e, RPL18 large subunit ribosomal protein L18e http://www.genome.jp/dbget-bin/www_bget?ko:K02883 Q4GXG7 719 8.7e-75 60S ribosomal protein L18 OS=Timarcha balearica GN=RpL18 PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1714 60s ribosomal protein L18 Cluster-8309.3628 BF_2 12.46 0.64 1105 91090532 XP_970543.1 987 2.6e-104 PREDICTED: WD repeat-containing protein on Y chromosome [Tribolium castaneum]>gi|270013353|gb|EFA09801.1| hypothetical protein TcasGA2_TC011944 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B7FF09 614 1.9e-62 WD repeat-containing protein on Y chromosome OS=Drosophila willistoni GN=WDY PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36280 BF_2 287.25 6.97 2012 642939029 XP_008200194.1 621 1.3e-61 PREDICTED: uncharacterized protein LOC103314860 [Tribolium castaneum]>gi|270016275|gb|EFA12721.1| hypothetical protein TcasGA2_TC002356 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D722 128 7.7e-06 Oxidative stress-responsive serine-rich protein 1 OS=Mus musculus GN=Oser1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36281 BF_2 21.00 0.94 1218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36282 BF_2 93.18 0.83 4999 642915135 XP_008190425.1 3064 0.0e+00 PREDICTED: importin-11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P79171 528 8.0e-52 Aminopeptidase N OS=Felis catus GN=ANPEP PE=1 SV=3 PF02671//PF01433 Paired amphipathic helix repeat//Peptidase family M1 GO:0006355 regulation of transcription, DNA-templated GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.36283 BF_2 616.59 20.22 1563 189235535 XP_972604.2 1850 3.1e-204 PREDICTED: cAMP-dependent protein kinase type I regulatory subunit isoform X1 [Tribolium castaneum]>gi|270003022|gb|EEZ99469.1| hypothetical protein TcasGA2_TC000040 [Tribolium castaneum] 817195912 XM_012418094.1 263 4.41001e-133 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X1, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1582 1.5e-174 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- GO:0045859//GO:0007165//GO:0001932 regulation of protein kinase activity//signal transduction//regulation of protein phosphorylation GO:0008603 cAMP-dependent protein kinase regulator activity GO:0005952 cAMP-dependent protein kinase complex KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.36284 BF_2 52.86 0.74 3264 478262395 ENN81066.1 2397 2.4e-267 hypothetical protein YQE_02435, partial [Dendroctonus ponderosae]>gi|546673615|gb|ERL85179.1| hypothetical protein D910_02601 [Dendroctonus ponderosae] 807040070 XM_004535125.2 125 4.81827e-56 PREDICTED: Ceratitis capitata plastin-3 (LOC101457045), transcript variant X2, mRNA K17336 PLS3 plastin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K17336 P13796 1297 3.5e-141 Plastin-2 OS=Homo sapiens GN=LCP1 PE=1 SV=6 PF00036//PF13833//PF13405//PF13499//PF00307//PF13202//PF04608 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Calponin homology (CH) domain//EF hand//Phosphatidylglycerophosphatase A GO:0046486//GO:0006629 glycerolipid metabolic process//lipid metabolic process GO:0005509//GO:0005515//GO:0008962 calcium ion binding//protein binding//phosphatidylglycerophosphatase activity -- -- KOG0046 Ca2+-binding actin-bundling protein (fimbrin/plastin), EF-Hand protein superfamily Cluster-8309.36286 BF_2 21.47 0.46 2235 642912272 XP_008200632.1 483 1.4e-45 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88947 148 4.1e-08 Coagulation factor X OS=Mus musculus GN=F10 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.36287 BF_2 69.00 3.63 1082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36288 BF_2 37.51 0.41 4144 546673612 ERL85176.1 5627 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911110 XM_008202361.1 589 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 2078 1.2e-231 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF16656//PF13895//PF00041//PF06293//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006771//GO:0006468//GO:0019497 riboflavin metabolic process//protein phosphorylation//hexachlorocyclohexane metabolic process GO:0046872//GO:0004672//GO:0016773//GO:0003993//GO:0005515//GO:0005524 metal ion binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//acid phosphatase activity//protein binding//ATP binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36289 BF_2 1297.70 7.20 7828 642927067 XP_008195123.1 5796 0.0e+00 PREDICTED: protein RIC1 homolog [Tribolium castaneum] 698415894 XM_009696085.1 54 3.42056e-16 PREDICTED: Cariama cristata RAB6A GEF complex partner 1 (RIC1), partial mRNA -- -- -- -- Q9V3C5 2693 1.1e-302 Guanine nucleotide exchange factor subunit Rich OS=Drosophila melanogaster GN=Rich PE=1 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG2006 WD40 repeat protein Cluster-8309.3629 BF_2 8.54 0.65 839 478259219 ENN79121.1 816 1.3e-84 hypothetical protein YQE_04308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B7FF09 447 3.3e-43 WD repeat-containing protein on Y chromosome OS=Drosophila willistoni GN=WDY PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36290 BF_2 1075.00 51.29 1164 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708//PF10384 Geminivirus putative movement protein//Centromere protein Scm3 GO:0046740 transport of virus in host, cell to cell GO:0042393 histone binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.36291 BF_2 302.12 25.39 785 642918417 XP_008191464.1 792 7.4e-82 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X2 [Tribolium castaneum] 462383650 APGK01021187.1 59 5.48363e-20 Dendroctonus ponderosae Seq01021197, whole genome shotgun sequence K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 Q63704 599 7.3e-61 Carnitine O-palmitoyltransferase 1, muscle isoform OS=Rattus norvegicus GN=Cpt1b PE=1 SV=1 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3716 Carnitine O-acyltransferase CPTI Cluster-8309.36292 BF_2 31841.00 847.94 1858 91080053 XP_973257.1 1304 7.5e-141 PREDICTED: ADP,ATP carrier protein 1 [Tribolium castaneum]>gi|270003211|gb|EEZ99658.1| hypothetical protein TcasGA2_TC002415 [Tribolium castaneum] -- -- -- -- -- K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q27238 1246 1.6e-135 ADP,ATP carrier protein 1 OS=Anopheles gambiae GN=AGAP006782 PE=2 SV=2 -- -- GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.36293 BF_2 1010.70 4.32 10068 91088249 XP_966392.1 4206 0.0e+00 PREDICTED: myosin-IA [Tribolium castaneum]>gi|270011817|gb|EFA08265.1| hypothetical protein TcasGA2_TC005895 [Tribolium castaneum] 573901209 XM_006638269.1 110 3.26302e-47 PREDICTED: Lepisosteus oculatus unconventional myosin-Id-like (LOC102690351), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 3028 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF00612//PF00063//PF06414//PF00437//PF06017 IQ calmodulin-binding motif//Myosin head (motor domain)//Zeta toxin//Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding GO:0006810 transport GO:0005515//GO:0005524//GO:0016301//GO:0003774 protein binding//ATP binding//kinase activity//motor activity GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.36294 BF_2 2638.00 44.90 2745 642911547 XP_974187.2 904 2.7e-94 PREDICTED: uncharacterized protein LOC663029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O54715 152 1.7e-08 V-type proton ATPase subunit S1 OS=Rattus norvegicus GN=Atp6ap1 PE=2 SV=1 PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.36295 BF_2 2982.00 145.76 1143 283046834 NP_001164360.1 1256 1.7e-135 succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial [Tribolium castaneum]>gi|270014261|gb|EFA10709.1| hypothetical protein TcasGA2_TC011988 [Tribolium castaneum] 255721638 XM_002545708.1 76 2.87152e-29 Candida tropicalis MYA-3404 succinate dehydrogenase iron-sulfur protein, mitochondrial precursor, mRNA K00235 SDHB, SDH2 succinate dehydrogenase (ubiquinone) iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00235 P21914 1096 2.5e-118 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial OS=Drosophila melanogaster GN=SdhB PE=2 SV=2 PF00111//PF13085//PF09788 2Fe-2S iron-sulfur cluster binding domain//2Fe-2S iron-sulfur cluster binding domain//Transmembrane protein 55A GO:0006099//GO:0006118//GO:0046856 tricarboxylic acid cycle//obsolete electron transport//phosphatidylinositol dephosphorylation GO:0034597//GO:0009055//GO:0051536//GO:0016491//GO:0051537 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//electron carrier activity//iron-sulfur cluster binding//oxidoreductase activity//2 iron, 2 sulfur cluster binding -- -- KOG3049 Succinate dehydrogenase, Fe-S protein subunit Cluster-8309.36296 BF_2 6868.83 196.56 1749 291170322 ADD82417.1 224 1.2e-15 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36297 BF_2 1771.98 33.23 2518 546684212 ERL93917.1 756 3.5e-77 hypothetical protein D910_11203 [Dendroctonus ponderosae] -- -- -- -- -- K03258 EIF4B translation initiation factor 4B http://www.genome.jp/dbget-bin/www_bget?ko:K03258 P23588 390 4.0e-36 Eukaryotic translation initiation factor 4B OS=Homo sapiens GN=EIF4B PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.36298 BF_2 1995.77 22.81 3948 -- -- -- -- -- 642922275 XM_001814946.2 56 1.32814e-17 PREDICTED: Tribolium castaneum glycine-rich cell wall structural protein 1.8 (LOC100142484), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF01853 MOZ/SAS family GO:0006355 regulation of transcription, DNA-templated GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.36299 BF_2 586.75 15.36 1885 478262394 ENN81065.1 797 4.7e-82 hypothetical protein YQE_02434, partial [Dendroctonus ponderosae]>gi|546673614|gb|ERL85178.1| hypothetical protein D910_02600 [Dendroctonus ponderosae] -- -- -- -- -- K16365 SGTA small glutamine-rich tetratricopeptide repeat-containing protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K16365 O43765 485 2.9e-47 Small glutamine-rich tetratricopeptide repeat-containing protein alpha OS=Homo sapiens GN=SGTA PE=1 SV=1 PF13176//PF13174//PF13414//PF13374//PF00515//PF13181//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0553 TPR repeat-containing protein Cluster-8309.36301 BF_2 47095.59 1757.72 1408 156481748 ABU68467.1 1398 7.1e-152 adenine nucleotide translocase [Monochamus alternatus] 156481747 EU093076.1 880 0 Monochamus alternatus adenine nucleotide translocase mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q26365 1264 1.0e-137 ADP,ATP carrier protein OS=Drosophila melanogaster GN=sesB PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.36302 BF_2 925.80 25.70 1794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36305 BF_2 315.99 1.87 7363 478262392 ENN81063.1 5910 0.0e+00 hypothetical protein YQE_02432, partial [Dendroctonus ponderosae] 642911110 XM_008202361.1 1052 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA K12567 TTN titin http://www.genome.jp/dbget-bin/www_bget?ko:K12567 Q23551 3022 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF16656//PF02480//PF00041//PF13895//PF16794//PF03739//PF01108 Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Fibronectin type III domain//Immunoglobulin domain//Fibronectin-III type domain//Predicted permease YjgP/YjgQ family//Tissue factor GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36306 BF_2 59108.59 890.45 3064 58294539 AAW70172.1 3372 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1253 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2258 1.2e-252 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36307 BF_2 28.56 0.57 2374 642931092 XP_008196207.1 1994 9.3e-221 PREDICTED: ATP-dependent RNA helicase DDX42 [Tribolium castaneum]>gi|270012072|gb|EFA08520.1| hypothetical protein TcasGA2_TC006173 [Tribolium castaneum] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1301 8.8e-142 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0008026//GO:0003676//GO:0003677//GO:0016787//GO:0005524 ATP-dependent helicase activity//nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0334 RNA helicase Cluster-8309.36308 BF_2 124.44 0.99 5547 478250717 ENN71209.1 490 5.5e-46 hypothetical protein YQE_12138, partial [Dendroctonus ponderosae]>gi|546678600|gb|ERL89182.1| hypothetical protein D910_06556 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344//PF08053//PF05497 Kelch motif//Tryptophanase operon leader peptide//Destabilase GO:0005975//GO:0031554//GO:0031556 carbohydrate metabolic process//regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome GO:0005515//GO:0003796 protein binding//lysozyme activity -- -- -- -- Cluster-8309.36309 BF_2 1072.35 11.52 4181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08136 30S ribosomal protein subunit S22 family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.36310 BF_2 3262.00 98.61 1671 91092724 XP_972731.1 1485 6.9e-162 PREDICTED: uncharacterized protein LOC661483 [Tribolium castaneum]>gi|270014877|gb|EFA11325.1| hypothetical protein TcasGA2_TC010864 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36311 BF_2 46280.86 2835.30 970 91091966 XP_967128.1 1175 3.6e-126 PREDICTED: tropomyosin-1 [Tribolium castaneum]>gi|270001148|gb|EEZ97595.1| hypothetical protein TcasGA2_TC011461 [Tribolium castaneum] 724090708 KM396883.1 616 0 Monochamus alternatus tropomyosin-1 mRNA, partial cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPU0 1098 1.2e-118 Tropomyosin-1 OS=Bombyx mori PE=1 SV=1 PF07926//PF04728//PF08702//PF06009//PF07851//PF06008//PF01496//PF10392//PF13851//PF05739//PF10473//PF06160//PF00015//PF00769//PF07928//PF04111//PF04048//PF16716//PF10186//PF09730 TPR/MLP1/MLP2-like protein//Lipoprotein leucine-zipper//Fibrinogen alpha/beta chain family//Laminin Domain II//TMPIT-like protein//Laminin Domain I//V-type ATPase 116kDa subunit family//Golgi transport complex subunit 5//Growth-arrest specific micro-tubule binding//SNARE domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Methyl-accepting chemotaxis protein (MCP) signalling domain//Ezrin/radixin/moesin family//Vps54-like protein//Autophagy protein Apg6//Sec8 exocyst complex component specific domain//Bone marrow stromal antigen 2//Vacuolar sorting 38 and autophagy-related subunit 14//Microtubule-associated protein Bicaudal-D GO:0051607//GO:0015991//GO:0007155//GO:0030155//GO:0051258//GO:0006914//GO:0006810//GO:0007165//GO:0030334//GO:0010508//GO:0015031//GO:0006904//GO:0048870//GO:0000921//GO:0006891//GO:0030168//GO:0015992//GO:0042147//GO:0045995//GO:0006606 defense response to virus//ATP hydrolysis coupled proton transport//cell adhesion//regulation of cell adhesion//protein polymerization//autophagy//transport//signal transduction//regulation of cell migration//positive regulation of autophagy//protein transport//vesicle docking involved in exocytosis//cell motility//septin ring assembly//intra-Golgi vesicle-mediated transport//platelet activation//proton transport//retrograde transport, endosome to Golgi//regulation of embryonic development//protein import into nucleus GO:0005515//GO:0042803//GO:0004871//GO:0015078//GO:0008092//GO:0030674//GO:0008134//GO:0045502//GO:0005102 protein binding//protein homodimerization activity//signal transducer activity//hydrogen ion transmembrane transporter activity//cytoskeletal protein binding//protein binding, bridging//transcription factor binding//dynein binding//receptor binding GO:0019867//GO:0033179//GO:0000145//GO:0017119//GO:0016020//GO:0005940//GO:0016021//GO:0031514//GO:0005737//GO:0005667//GO:0030286//GO:0005794//GO:0019898//GO:0005577 outer membrane//proton-transporting V-type ATPase, V0 domain//exocyst//Golgi transport complex//membrane//septin ring//integral component of membrane//motile cilium//cytoplasm//transcription factor complex//dynein complex//Golgi apparatus//extrinsic component of membrane//fibrinogen complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.36312 BF_2 108.18 2.13 2410 568253794 ETN62859.1 2234 1.4e-248 Elongation factor 1-alpha 2 [Anopheles darlingi] 727098916 KJ534557.1 786 0 Colaphellus bowringi elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P05303 2201 3.9e-246 Elongation factor 1-alpha 2 OS=Drosophila melanogaster GN=Ef1alpha100E PE=2 SV=2 PF03144//PF02615//PF01926 Elongation factor Tu domain 2//Malate/L-lactate dehydrogenase//50S ribosome-binding GTPase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0005525//GO:0016491 GTP binding//oxidoreductase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.36314 BF_2 62.03 0.44 6215 91086459 XP_969641.1 1106 2.3e-117 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 P57093 721 4.1e-74 Phytanoyl-CoA dioxygenase, peroxisomal OS=Rattus norvegicus GN=Phyh PE=1 SV=2 PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.36315 BF_2 3525.38 45.13 3555 642936487 XP_008198457.1 2347 1.6e-261 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.3582e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1251 8.2e-136 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF01699//PF00060//PF10613//PF05699 Sodium/calcium exchanger protein//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//hAT family C-terminal dimerisation region GO:0055085//GO:0007165//GO:0007268//GO:0006811 transmembrane transport//signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970//GO:0046983//GO:0005216 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//protein dimerization activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.36317 BF_2 390.30 6.07 2976 642910216 XP_008198443.1 2351 4.7e-262 PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum]>gi|642910218|ref|XP_967637.2| PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum] 642910217 XM_962544.2 492 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC655987), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 P49802 1458 6.9e-160 Regulator of G-protein signaling 7 OS=Homo sapiens GN=RGS7 PE=1 SV=3 PF00610//PF00631 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//GGL domain GO:0007186//GO:0007165//GO:0035556 G-protein coupled receptor signaling pathway//signal transduction//intracellular signal transduction GO:0004871 signal transducer activity GO:0005834 heterotrimeric G-protein complex KOG3589 G protein signaling regulators Cluster-8309.36319 BF_2 83.08 0.83 4480 478252681 ENN73077.1 393 7.8e-35 hypothetical protein YQE_10281, partial [Dendroctonus ponderosae]>gi|546682841|gb|ERL92730.1| hypothetical protein D910_10040 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06859 Bicoid-interacting protein 3 (Bin3) -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.36320 BF_2 485.97 21.70 1224 60300016 AAX18656.1 151 2.5e-07 cysteine-rich protein [Apriona germari] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36321 BF_2 7048.00 1636.97 467 389608135 BAM17679.1 323 1.1e-27 ribosomal protein LP2 [Papilio xuthus]>gi|389610557|dbj|BAM18890.1| ribosomal protein LP2 [Papilio polytes] -- -- -- -- -- K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P05389 281 3.2e-24 60S acidic ribosomal protein P2 OS=Drosophila melanogaster GN=RpLP2 PE=1 SV=1 PF13184 NusA-like KH domain -- -- GO:0003723 RNA binding -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-8309.36322 BF_2 8113.88 121.27 3086 58294539 AAW70172.1 3372 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1253 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2258 1.2e-252 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006879//GO:0006826 cellular iron ion homeostasis//iron ion transport GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36324 BF_2 115.75 5.81 1120 642911969 XP_008199043.1 634 2.2e-63 PREDICTED: elongation factor 1-delta isoform X2 [Tribolium castaneum] -- -- -- -- -- K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 Q9VL18 446 5.7e-43 Probable elongation factor 1-delta OS=Drosophila melanogaster GN=eEF1delta PE=1 SV=1 PF08702//PF02346//PF00736//PF10152 Fibrinogen alpha/beta chain family//Chordopoxvirus multifunctional envelope protein A27//EF-1 guanine nucleotide exchange domain//Predicted coiled-coil domain-containing protein (DUF2360) GO:0006448//GO:0051258//GO:0019064//GO:0006414//GO:0007165//GO:0030168 regulation of translational elongation//protein polymerization//fusion of virus membrane with host plasma membrane//translational elongation//signal transduction//platelet activation GO:0030674//GO:0005102//GO:0003746 protein binding, bridging//receptor binding//translation elongation factor activity GO:0019031//GO:0071203//GO:0005577//GO:0005853//GO:0005840 viral envelope//WASH complex//fibrinogen complex//eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.36325 BF_2 1343.88 14.00 4304 546683575 ERL93373.1 1505 8.6e-164 hypothetical protein D910_10665 [Dendroctonus ponderosae] 642921542 XM_970634.3 225 1.63866e-111 PREDICTED: Tribolium castaneum uncharacterized LOC655573 (LOC655573), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36327 BF_2 1434.00 30.70 2241 642911471 XP_008199437.1 1821 1.0e-200 PREDICTED: LOW QUALITY PROTEIN: dihydropyrimidinase [Tribolium castaneum] 762124057 XM_011446728.1 87 4.38312e-35 PREDICTED: Crassostrea gigas dihydropyrimidinase-like (LOC105340590), transcript variant X7, mRNA K01464 DPYS, dht, hydA dihydropyrimidinase http://www.genome.jp/dbget-bin/www_bget?ko:K01464 Q63150 1134 1.9e-122 Dihydropyrimidinase OS=Rattus norvegicus GN=Dpys PE=1 SV=2 PF01979 Amidohydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG2584 Dihydroorotase and related enzymes Cluster-8309.36329 BF_2 95.79 1.02 4232 642914748 XP_008190336.1 5332 0.0e+00 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 1137 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q8QFV0 1603 1.5e-176 Potassium channel subfamily T member 1 OS=Gallus gallus GN=KCNT1 PE=2 SV=1 PF01022//PF03493//PF00520 Bacterial regulatory protein, arsR family//Calcium-activated BK potassium channel alpha subunit//Ion transport protein GO:0006355//GO:0006811//GO:0055085//GO:0006813 regulation of transcription, DNA-templated//ion transport//transmembrane transport//potassium ion transport GO:0005216//GO:0003700//GO:0015269 ion channel activity//transcription factor activity, sequence-specific DNA binding//calcium-activated potassium channel activity GO:0016020//GO:0005667 membrane//transcription factor complex KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.36330 BF_2 134082.00 7333.57 1052 556505471 YP_008757568.1 1040 1.7e-110 NADH dehydrogenase subunit 1 (mitochondrion) [Batocera lineolata]>gi|359294294|gb|AEV21663.1| NADH dehydrogenase subunit 1 [Batocera lineolata] 359294281 JN986793.1 731 0 Batocera lineolata mitochondrion, complete genome K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 B0FWD8 849 1.0e-89 NADH-ubiquinone oxidoreductase chain 1 OS=Aedes aegypti GN=mt:ND1 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4770 NADH dehydrogenase subunit 1 Cluster-8309.36331 BF_2 6125.53 45.11 5968 642938243 XP_008198126.1 1652 1.1e-180 PREDICTED: serine/threonine-protein kinase Doa isoform X1 [Tribolium castaneum] 642938246 XM_008199906.1 405 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 1386 3.1e-151 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF10399//PF07714//PF06553//PF00069//PF05445 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Protein tyrosine kinase//BNIP3//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006118//GO:0043065//GO:0015992//GO:0055114//GO:0006119//GO:0006468 obsolete electron transport//positive regulation of apoptotic process//proton transport//oxidation-reduction process//oxidative phosphorylation//protein phosphorylation GO:0004672//GO:0005524//GO:0008121 protein kinase activity//ATP binding//ubiquinol-cytochrome-c reductase activity GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane KOG0671 LAMMER dual specificity kinases Cluster-8309.36332 BF_2 6545.00 65.94 4439 91087187 XP_975429.1 1334 5.9e-144 PREDICTED: la-related protein 6 [Tribolium castaneum]>gi|270009568|gb|EFA06016.1| hypothetical protein TcasGA2_TC008844 [Tribolium castaneum] -- -- -- -- -- K18733 LARP6 la-related protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18733 Q9BRS8 386 2.1e-35 La-related protein 6 OS=Homo sapiens GN=LARP6 PE=1 SV=1 PF00076//PF08336 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0006525//GO:0018401//GO:0006560//GO:0055114 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//proline metabolic process//oxidation-reduction process GO:0004656//GO:0016702//GO:0003676 procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//nucleic acid binding GO:0005783 endoplasmic reticulum KOG1855 Predicted RNA-binding protein Cluster-8309.36333 BF_2 14307.00 310.61 2214 86515394 NP_001034522.1 2725 1.5e-305 pro-phenol oxidase subunit 2 [Tribolium castaneum]>gi|70999576|gb|AAX84205.1| pro-phenol oxidase subunit 2 [Tribolium castaneum] 195585904 XM_002082683.1 49 5.76127e-14 Drosophila simulans GD11733 (Dsim\GD11733), mRNA -- -- -- -- Q9V521 2233 6.9e-250 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 PF00264 Common central domain of tyrosinase GO:0006118//GO:0006771//GO:0055114//GO:0009805//GO:0008152//GO:0009811//GO:0009821//GO:0009809//GO:0006570 obsolete electron transport//riboflavin metabolic process//oxidation-reduction process//coumarin biosynthetic process//metabolic process//stilbene biosynthetic process//alkaloid biosynthetic process//lignin biosynthetic process//tyrosine metabolic process GO:0004503//GO:0016491//GO:0004097 monophenol monooxygenase activity//oxidoreductase activity//catechol oxidase activity -- -- -- -- Cluster-8309.36334 BF_2 804.37 86.53 676 642913220 XP_008201444.1 269 2.8e-21 PREDICTED: inducible metalloproteinase inhibitor protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82176 206 2.3e-15 Inducible metalloproteinase inhibitor protein OS=Galleria mellonella GN=IMPI PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36335 BF_2 1342.43 34.02 1938 642934812 XP_008197820.1 552 1.2e-53 PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934814|ref|XP_008197821.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934816|ref|XP_008197822.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum]>gi|642934818|ref|XP_008197823.1| PREDICTED: protein phosphatase 1 regulatory subunit 14B [Tribolium castaneum] -- -- -- -- -- K17555 PPP1R14B protein phosphatase 1 regulatory subunit 14B http://www.genome.jp/dbget-bin/www_bget?ko:K17555 -- -- -- -- PF05361 PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation -- -- GO:0005737 cytoplasm -- -- Cluster-8309.36336 BF_2 687.00 17.43 1936 478257905 ENN78045.1 806 4.3e-83 hypothetical protein YQE_05482, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H3L0 251 4.1e-20 Methylmalonic aciduria and homocystinuria type D protein, mitochondrial OS=Homo sapiens GN=MMADHC PE=1 SV=2 PF10229 Uncharacterized conserved protein (DUF2246) GO:0009235 cobalamin metabolic process -- -- -- -- KOG3994 Uncharacterized conserved protein Cluster-8309.36337 BF_2 31.97 1.91 988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36338 BF_2 5709.03 185.88 1572 91077022 XP_976032.1 650 4.3e-65 PREDICTED: uncharacterized protein LOC655336 [Tribolium castaneum]>gi|270001753|gb|EEZ98200.1| hypothetical protein TcasGA2_TC000630 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36339 BF_2 11.09 1.83 541 529172383 BAN67667.1 141 1.6e-06 riptocin [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q27905 141 6.5e-08 Probable antibacterial peptide polyprotein OS=Riptortus clavatus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3634 BF_2 9.50 1.15 633 642936195 XP_008198341.1 391 1.9e-35 PREDICTED: sp-like zinc finger transcription factor isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36340 BF_2 511.54 2.81 7906 546677249 ERL88118.1 2766 9.3e-310 hypothetical protein D910_05507 [Dendroctonus ponderosae] 642931318 XM_008198308.1 1005 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X30, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2646 3.2e-297 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF07926//PF07259//PF08702//PF00038//PF02601//PF16331//PF16326//PF06009//PF00957//PF04977//PF07352//PF08597//PF00517//PF00487//PF06160//PF05557//PF17060//PF06657//PF11382//PF04111//PF04108//PF16716//PF10186//PF01576 TPR/MLP1/MLP2-like protein//ProSAAS precursor//Fibrinogen alpha/beta chain family//Intermediate filament protein//Exonuclease VII, large subunit//TolA binding protein trimerisation//ABC transporter C-terminal domain//Laminin Domain II//Synaptobrevin//Septum formation initiator//Bacteriophage Mu Gam like protein//Translation initiation factor eIF3 subunit//Retroviral envelope protein//Fatty acid desaturase//Septation ring formation regulator, EzrA//Mitotic checkpoint protein//Monopolar spindle protein 2//Centrosome microtubule-binding domain of Cep57//Copper transport outer membrane protein, MctB//Autophagy protein Apg6//Autophagy protein Apg17//Bone marrow stromal antigen 2//Vacuolar sorting 38 and autophagy-related subunit 14//Myosin tail GO:0010508//GO:0007049//GO:0070206//GO:0006810//GO:0016192//GO:0006914//GO:0010951//GO:0051258//GO:0007165//GO:0006308//GO:0007094//GO:0071988//GO:0007155//GO:0006629//GO:0051607//GO:0006606//GO:0030168//GO:0006446//GO:0000921//GO:0030474//GO:0042262 positive regulation of autophagy//cell cycle//protein trimerization//transport//vesicle-mediated transport//autophagy//negative regulation of endopeptidase activity//protein polymerization//signal transduction//DNA catabolic process//mitotic spindle assembly checkpoint//protein localization to spindle pole body//cell adhesion//lipid metabolic process//defense response to virus//protein import into nucleus//platelet activation//regulation of translational initiation//septin ring assembly//spindle pole body duplication//DNA protection GO:0005198//GO:0003690//GO:0008017//GO:0008855//GO:0003677//GO:0005102//GO:0003743//GO:0003774//GO:0030674//GO:0004866 structural molecule activity//double-stranded DNA binding//microtubule binding//exodeoxyribonuclease VII activity//DNA binding//receptor binding//translation initiation factor activity//motor activity//protein binding, bridging//endopeptidase inhibitor activity GO:0005737//GO:0005840//GO:0005940//GO:0016459//GO:0016021//GO:0005852//GO:0019031//GO:0005577//GO:0009318//GO:0045298//GO:0005882 cytoplasm//ribosome//septin ring//myosin complex//integral component of membrane//eukaryotic translation initiation factor 3 complex//viral envelope//fibrinogen complex//exodeoxyribonuclease VII complex//tubulin complex//intermediate filament -- -- Cluster-8309.36341 BF_2 40.73 0.45 4053 332376933 AEE63606.1 1622 2.2e-177 unknown [Dendroctonus ponderosae] 827538802 XM_012696885.1 74 1.34463e-27 PREDICTED: Bombyx mori phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform (LOC101743489), transcript variant X3, mRNA K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q01604 1393 3.2e-152 Phosphoglycerate kinase OS=Drosophila melanogaster GN=Pgk PE=2 SV=2 PF00162//PF00069//PF01645 Phosphoglycerate kinase//Protein kinase domain//Conserved region in glutamate synthase GO:0055114//GO:0006094//GO:0015976//GO:0006468//GO:0016310//GO:0006096//GO:0006537 oxidation-reduction process//gluconeogenesis//carbon utilization//protein phosphorylation//phosphorylation//glycolytic process//glutamate biosynthetic process GO:0015930//GO:0004672//GO:0016638//GO:0004618//GO:0005524 glutamate synthase activity//protein kinase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//phosphoglycerate kinase activity//ATP binding -- -- KOG1367 3-phosphoglycerate kinase Cluster-8309.36342 BF_2 15384.45 491.71 1596 270010228 EFA06676.1 507 1.7e-48 hypothetical protein TcasGA2_TC009606 [Tribolium castaneum] 366039975 NM_001256069.1 175 3.73809e-84 Tribolium castaneum ornithine decarboxylase antizyme az (az), mRNA K16548 OAZ1 ornithine decarboxylase antizyme 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16548 P54368 177 1.3e-11 Ornithine decarboxylase antizyme 1 OS=Homo sapiens GN=OAZ1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36343 BF_2 16383.50 614.21 1403 332376705 AEE63492.1 591 2.7e-58 unknown [Dendroctonus ponderosae] 332376704 BT128535.1 264 1.09776e-133 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 467 2.6e-45 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF09416 Troponin//RNA helicase (UPF2 interacting domain) GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0003677//GO:0004386//GO:0008270//GO:0005524 DNA binding//helicase activity//zinc ion binding//ATP binding GO:0005737//GO:0005861 cytoplasm//troponin complex KOG3977 Troponin I Cluster-8309.36344 BF_2 14.06 0.60 1261 571516260 XP_006569195.1 225 6.7e-16 PREDICTED: histidine-rich glycoprotein-like [Apis mellifera] -- -- -- -- -- -- -- -- -- P04929 190 3.1e-13 Histidine-rich glycoprotein OS=Plasmodium lophurae PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36345 BF_2 71028.67 351.26 8746 478250666 ENN71158.1 3127 0.0e+00 hypothetical protein YQE_12088, partial [Dendroctonus ponderosae] 642931311 XM_001813763.2 1453 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X26, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2919 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00487//PF09177//PF00322//PF07926//PF00038//PF00769//PF08702//PF04111//PF04977//PF00612//PF08375//PF01496//PF01576 Fatty acid desaturase//Syntaxin 6, N-terminal//Endothelin family//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Autophagy protein Apg6//Septum formation initiator//IQ calmodulin-binding motif//Proteasome regulatory subunit C-terminal//V-type ATPase 116kDa subunit family//Myosin tail GO:0048193//GO:0006629//GO:0015991//GO:0030168//GO:0007165//GO:0019229//GO:0006914//GO:0051258//GO:0006606//GO:0042176//GO:0015992//GO:0007049 Golgi vesicle transport//lipid metabolic process//ATP hydrolysis coupled proton transport//platelet activation//signal transduction//regulation of vasoconstriction//autophagy//protein polymerization//protein import into nucleus//regulation of protein catabolic process//proton transport//cell cycle GO:0008092//GO:0005515//GO:0003774//GO:0030674//GO:0005198//GO:0015078//GO:0005102//GO:0030234 cytoskeletal protein binding//protein binding//motor activity//protein binding, bridging//structural molecule activity//hydrogen ion transmembrane transporter activity//receptor binding//enzyme regulator activity GO:0016020//GO:0005576//GO:0033179//GO:0016459//GO:0019898//GO:0005882//GO:0000502//GO:0005577//GO:0005737 membrane//extracellular region//proton-transporting V-type ATPase, V0 domain//myosin complex//extrinsic component of membrane//intermediate filament//proteasome complex//fibrinogen complex//cytoplasm -- -- Cluster-8309.36346 BF_2 60.57 0.48 5539 699049757 AIU39233.1 742 3.3e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 560 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 1.1e-70 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF10186//PF03577//PF15898//PF00769//PF11365//PF10473//PF05739//PF06160//PF14073//PF07851//PF16326//PF06009//PF02601//PF04513//PF08702//PF07926 Vacuolar sorting 38 and autophagy-related subunit 14//Peptidase family C69//cGMP-dependent protein kinase interacting domain//Ezrin/radixin/moesin family//Protein of unknown function (DUF3166)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Septation ring formation regulator, EzrA//Centrosome localisation domain of Cep57//TMPIT-like protein//ABC transporter C-terminal domain//Laminin Domain II//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein GO:0006308//GO:0007155//GO:0051258//GO:0007165//GO:0010508//GO:0000921//GO:0030168//GO:0006508//GO:0010506//GO:0006606 DNA catabolic process//cell adhesion//protein polymerization//signal transduction//positive regulation of autophagy//septin ring assembly//platelet activation//proteolysis//regulation of autophagy//protein import into nucleus GO:0005515//GO:0008855//GO:0003677//GO:0042802//GO:0043015//GO:0042803//GO:0005198//GO:0016805//GO:0019901//GO:0008092//GO:0030674//GO:0045502//GO:0008134//GO:0005102 protein binding//exodeoxyribonuclease VII activity//DNA binding//identical protein binding//gamma-tubulin binding//protein homodimerization activity//structural molecule activity//dipeptidase activity//protein kinase binding//cytoskeletal protein binding//protein binding, bridging//dynein binding//transcription factor binding//receptor binding GO:0019031//GO:0005940//GO:0016021//GO:0005737//GO:0005667//GO:0030286//GO:0045298//GO:0019898//GO:0019028//GO:0005577//GO:0005615//GO:0009318 viral envelope//septin ring//integral component of membrane//cytoplasm//transcription factor complex//dynein complex//tubulin complex//extrinsic component of membrane//viral capsid//fibrinogen complex//extracellular space//exodeoxyribonuclease VII complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.36347 BF_2 24.98 0.77 1638 571516260 XP_006569195.1 224 1.1e-15 PREDICTED: histidine-rich glycoprotein-like [Apis mellifera] -- -- -- -- -- -- -- -- -- P04929 188 6.9e-13 Histidine-rich glycoprotein OS=Plasmodium lophurae PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36349 BF_2 35.06 1.23 1484 642916569 XP_008191733.1 301 1.2e-24 PREDICTED: uncharacterized protein LOC103312564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36350 BF_2 105.25 0.54 8393 546676647 ERL87611.1 699 4.8e-70 hypothetical protein D910_05002 [Dendroctonus ponderosae] 527266023 XM_005151139.1 53 1.31947e-15 PREDICTED: Melopsittacus undulatus solute carrier family 1 (glutamate transporter), member 7 (LOC101873134), mRNA K05617 SLC1A6, EAAT4 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K05617 O35921 497 5.3e-48 Excitatory amino acid transporter 4 OS=Rattus norvegicus GN=Slc1a6 PE=2 SV=1 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006812//GO:0006835 anion transport//cation transport//dicarboxylic acid transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.36351 BF_2 1071.25 27.21 1934 642925292 XP_001814214.2 1104 1.2e-117 PREDICTED: uncharacterized protein LOC100142468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36352 BF_2 29602.16 462.43 2965 91082223 XP_975988.1 1735 1.3e-190 PREDICTED: four and a half LIM domains protein 2 isoform X5 [Tribolium castaneum] 642922338 XM_970895.3 496 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X5, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 6.7e-107 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF00412//PF07562 LIM domain//Nine Cysteines Domain of family 3 GPCR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.36353 BF_2 5917.94 38.71 6683 642922676 XP_008193275.1 5069 0.0e+00 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X7 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 1706 2.7e-188 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF13895//PF02443//PF01086//PF00815//PF00057//PF10584 Immunoglobulin domain//Circovirus capsid protein//Clathrin light chain//Histidinol dehydrogenase//Low-density lipoprotein receptor domain class A//Proteasome subunit A N-terminal signature GO:0019069//GO:0000105//GO:0006511//GO:0055114//GO:0006886//GO:0016192 viral capsid assembly//histidine biosynthetic process//ubiquitin-dependent protein catabolic process//oxidation-reduction process//intracellular protein transport//vesicle-mediated transport GO:0004175//GO:0005515//GO:0051287//GO:0008270//GO:0004399//GO:0005198 endopeptidase activity//protein binding//NAD binding//zinc ion binding//histidinol dehydrogenase activity//structural molecule activity GO:0030130//GO:0019773//GO:0030132//GO:0042025 clathrin coat of trans-Golgi network vesicle//proteasome core complex, alpha-subunit complex//clathrin coat of coated pit//host cell nucleus KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.36354 BF_2 2806.81 67.76 2020 332375044 AEE62663.1 1970 4.8e-218 unknown [Dendroctonus ponderosae]>gi|478250038|gb|ENN70544.1| hypothetical protein YQE_12719, partial [Dendroctonus ponderosae]>gi|546672620|gb|ERL84416.1| hypothetical protein D910_01849 [Dendroctonus ponderosae] 332375043 BT127701.1 341 2.50101e-176 Dendroctonus ponderosae clone DPO096_E18 unknown mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 P34455 1632 3.1e-180 Probable aconitate hydratase, mitochondrial OS=Caenorhabditis elegans GN=aco-2 PE=3 SV=2 PF00330 Aconitase family (aconitate hydratase) GO:0008152 metabolic process -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.36355 BF_2 11947.37 243.46 2340 332373768 AEE62025.1 1732 2.2e-190 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W303 1137 9.0e-123 Chitinase-like protein Idgf4 OS=Drosophila melanogaster GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.36356 BF_2 445.66 8.51 2479 270005044 EFA01492.1 3824 0.0e+00 hypothetical protein TcasGA2_TC007046 [Tribolium castaneum] 817215189 XM_012428330.1 84 2.25928e-33 PREDICTED: Orussus abietinus E3 ubiquitin-protein ligase HECTD1 (LOC105701521), transcript variant X4, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2740 1.3e-308 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF06701 Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0046872 ubiquitin-protein transferase activity//metal ion binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.36357 BF_2 1263.79 25.31 2376 478258440 ENN78530.1 451 7.8e-42 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q55BM1 131 4.1e-06 Probable inactive protein kinase DDB_G0270444 OS=Dictyostelium discoideum GN=DDB_G0270444 PE=1 SV=1 PF02601//PF04210//PF05478 Exonuclease VII, large subunit//Tetrahydromethanopterin S-methyltransferase, subunit G//Prominin GO:0006308//GO:0046656//GO:0015948 DNA catabolic process//folic acid biosynthetic process//methanogenesis GO:0008855//GO:0030269 exodeoxyribonuclease VII activity//tetrahydromethanopterin S-methyltransferase activity GO:0009318//GO:0016021 exodeoxyribonuclease VII complex//integral component of membrane -- -- Cluster-8309.3636 BF_2 18.00 0.64 1468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36361 BF_2 27471.28 1884.43 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36362 BF_2 2219.06 59.66 1843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36363 BF_2 5434.14 24.26 9657 478252680 ENN73076.1 475 5.2e-44 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36364 BF_2 7979.42 35.53 9682 478252680 ENN73076.1 475 5.2e-44 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36365 BF_2 151.78 0.44 14583 642938921 XP_008195601.1 3295 0.0e+00 PREDICTED: PHD finger protein rhinoceros [Tribolium castaneum] 642938920 XM_008197379.1 365 0 PREDICTED: Tribolium castaneum PHD finger protein rhinoceros (LOC659824), mRNA -- -- -- -- Q7YZH1 1379 4.9e-150 PHD finger protein rhinoceros OS=Drosophila melanogaster GN=rno PE=1 SV=1 PF14560//PF00628//PF00130//PF00312//PF02214//PF03708//PF02136 Ubiquitin-like domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ribosomal protein S15//BTB/POZ domain//Avian retrovirus envelope protein, gp85//Nuclear transport factor 2 (NTF2) domain GO:0051260//GO:0006412//GO:0006810//GO:0035556//GO:0042254 protein homooligomerization//translation//transport//intracellular signal transduction//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0019031//GO:0005840//GO:0005622 viral envelope//ribosome//intracellular KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain Cluster-8309.36366 BF_2 2962.03 163.50 1045 478263359 ENN81735.1 181 7.0e-11 hypothetical protein YQE_01874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36367 BF_2 229.00 4.12 2611 642937601 XP_008199116.1 2273 4.6e-253 PREDICTED: probable ATP-dependent RNA helicase CG8611 [Tribolium castaneum] -- -- -- -- -- K14806 DDX31, DBP7 ATP-dependent RNA helicase DDX31/DBP7 http://www.genome.jp/dbget-bin/www_bget?ko:K14806 Q86B47 1048 2.1e-112 Probable ATP-dependent RNA helicase CG8611 OS=Drosophila melanogaster GN=CG8611 PE=1 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524 hydrolase activity//DNA binding//nucleic acid binding//ATP binding -- -- KOG0348 ATP-dependent RNA helicase Cluster-8309.36368 BF_2 310.46 1.35 9919 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 436 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF01436//PF08165//PF00097//PF01601//PF03884//PF14634//PF00643//PF04566//PF13639//PF10588//PF04513//PF00651 NHL repeat//FerA (NUC095) domain//Zinc finger, C3HC4 type (RING finger)//Coronavirus S2 glycoprotein//Domain of unknown function (DUF329)//zinc-RING finger domain//B-box zinc finger//RNA polymerase Rpb2, domain 4//Ring finger domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Baculovirus polyhedron envelope protein, PEP, C terminus//BTB/POZ domain GO:0046813//GO:0006206//GO:0061025//GO:0006144//GO:0006351//GO:0055114 receptor-mediated virion attachment to host cell//pyrimidine nucleobase metabolic process//membrane fusion//purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process GO:0046872//GO:0005515//GO:0016491//GO:0003677//GO:0008270//GO:0005198//GO:0003899 metal ion binding//protein binding//oxidoreductase activity//DNA binding//zinc ion binding//structural molecule activity//DNA-directed RNA polymerase activity GO:0019031//GO:0005730//GO:0005622//GO:0016021//GO:0019028 viral envelope//nucleolus//intracellular//integral component of membrane//viral capsid KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.36369 BF_2 624.46 15.40 1983 270001906 EEZ98353.1 159 4.7e-08 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36370 BF_2 82.11 1.84 2158 642937725 XP_008198919.1 550 2.3e-53 PREDICTED: tropomyosin-2 isoform X13 [Tribolium castaneum] 699049756 KM099072.1 334 2.0825e-172 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 480 1.3e-46 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF15898//PF04612//PF02601//PF08702//PF04799//PF02185//PF10473//PF05739//PF10186//PF10392//PF08651//PF05531//PF16326//PF06009 cGMP-dependent protein kinase interacting domain//Type II secretion system (T2SS), protein M//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//fzo-like conserved region//Hr1 repeat//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Vacuolar sorting 38 and autophagy-related subunit 14//Golgi transport complex subunit 5//DASH complex subunit Duo1//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Laminin Domain II GO:0007165//GO:0051258//GO:0007067//GO:0006858//GO:0010508//GO:0006891//GO:0030168//GO:0007155//GO:0008053//GO:0006308 signal transduction//protein polymerization//mitotic nuclear division//extracellular transport//positive regulation of autophagy//intra-Golgi vesicle-mediated transport//platelet activation//cell adhesion//mitochondrial fusion//DNA catabolic process GO:0045502//GO:0003924//GO:0008134//GO:0019901//GO:0005102//GO:0003677//GO:0005515//GO:0008855//GO:0030674//GO:0042803 dynein binding//GTPase activity//transcription factor binding//protein kinase binding//receptor binding//DNA binding//protein binding//exodeoxyribonuclease VII activity//protein binding, bridging//protein homodimerization activity GO:0016021//GO:0019028//GO:0009318//GO:0042729//GO:0005577//GO:0030286//GO:0072686//GO:0005667//GO:0017119//GO:0005741 integral component of membrane//viral capsid//exodeoxyribonuclease VII complex//DASH complex//fibrinogen complex//dynein complex//mitotic spindle//transcription factor complex//Golgi transport complex//mitochondrial outer membrane KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.36371 BF_2 3202.00 35.06 4108 91092064 XP_970689.1 2035 2.8e-225 PREDICTED: selenium-binding protein 1 [Tribolium castaneum]>gi|270004695|gb|EFA01143.1| hypothetical protein TcasGA2_TC010368 [Tribolium castaneum] -- -- -- -- -- K17285 SELENBP1 selenium-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17285 Q52KZ7 1535 1.1e-168 Selenium-binding protein 1-A OS=Xenopus laevis GN=selenbp1-a PE=2 SV=1 PF00474//PF06432//PF05694 Sodium:solute symporter family//Phosphatidylinositol N-acetylglucosaminyltransferase//56kDa selenium binding protein (SBP56) GO:0006506//GO:0006810//GO:0055085 GPI anchor biosynthetic process//transport//transmembrane transport GO:0008430//GO:0005215//GO:0017176 selenium binding//transporter activity//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0918 Selenium-binding protein Cluster-8309.36372 BF_2 358.51 2.07 7521 507228 AAA64736.1 693 2.1e-69 apolipophorin-III, partial [Derobrachus geminatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07464//PF03623//PF10280//PF00430//PF05866//PF06667//PF04108//PF05823//PF00804//PF04799//PF04513//PF02601//PF05478//PF06008//PF01442//PF02993//PF05531//PF01474//PF06320//PF14942 Apolipophorin-III precursor (apoLp-III)//Focal adhesion targeting region//Mediator complex protein//ATP synthase B/B' CF(0)//Endodeoxyribonuclease RusA//Phage shock protein B//Autophagy protein Apg17//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Syntaxin//fzo-like conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//Prominin//Laminin Domain I//Apolipoprotein A1/A4/E domain//Minor capsid protein VI//Nucleopolyhedrovirus P10 protein//Class-II DAHP synthetase family//GCN5-like protein 1 (GCN5L1)//Organelle biogenesis, Muted-like protein GO:0007172//GO:0008053//GO:0006310//GO:0000162//GO:0009073//GO:0006357//GO:0045995//GO:0015992//GO:0006571//GO:0042157//GO:0006869//GO:0015986//GO:0030155//GO:0009094//GO:0006308//GO:0009271//GO:0030334//GO:0007165//GO:0006281//GO:0006914//GO:0006468//GO:0006355 signal complex assembly//mitochondrial fusion//DNA recombination//tryptophan biosynthetic process//aromatic amino acid family biosynthetic process//regulation of transcription from RNA polymerase II promoter//regulation of embryonic development//proton transport//tyrosine biosynthetic process//lipoprotein metabolic process//lipid transport//ATP synthesis coupled proton transport//regulation of cell adhesion//L-phenylalanine biosynthetic process//DNA catabolic process//phage shock//regulation of cell migration//signal transduction//DNA repair//autophagy//protein phosphorylation//regulation of transcription, DNA-templated GO:0001104//GO:0008289//GO:0003924//GO:0005102//GO:0004713//GO:0008855//GO:0004871//GO:0000287//GO:0005198//GO:0003849//GO:0015078 RNA polymerase II transcription cofactor activity//lipid binding//GTPase activity//receptor binding//protein tyrosine kinase activity//exodeoxyribonuclease VII activity//signal transducer activity//magnesium ion binding//structural molecule activity//3-deoxy-7-phosphoheptulonate synthase activity//hydrogen ion transmembrane transporter activity GO:0016592//GO:0031083//GO:0005925//GO:0019028//GO:0009318//GO:0019031//GO:0016020//GO:0005576//GO:0005741//GO:0030133//GO:0016021//GO:0045263 mediator complex//BLOC-1 complex//focal adhesion//viral capsid//exodeoxyribonuclease VII complex//viral envelope//membrane//extracellular region//mitochondrial outer membrane//transport vesicle//integral component of membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.36373 BF_2 266.95 0.93 12241 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 6.83368e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01884//PF06574//PF01207//PF01593//PF07992//PF01704//PF04218//PF00070//PF00196//PF01180//PF05946//PF02796//PF05225//PF03184//PF04545 PcrB family//FAD synthetase//Dihydrouridine synthase (Dus)//Flavin containing amine oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//UTP--glucose-1-phosphate uridylyltransferase//CENP-B N-terminal DNA-binding domain//Pyridine nucleotide-disulphide oxidoreductase//Bacterial regulatory proteins, luxR family//Dihydroorotate dehydrogenase//Toxin-coregulated pilus subunit TcpA//Helix-turn-helix domain of resolvase//helix-turn-helix, Psq domain//DDE superfamily endonuclease//Sigma-70, region 4 GO:0006310//GO:0006771//GO:0009231//GO:0008152//GO:0055114//GO:0006118//GO:0006352//GO:0006206//GO:0006222//GO:0008033//GO:0006355//GO:0009405//GO:0006207 DNA recombination//riboflavin metabolic process//riboflavin biosynthetic process//metabolic process//oxidation-reduction process//obsolete electron transport//DNA-templated transcription, initiation//pyrimidine nucleobase metabolic process//UMP biosynthetic process//tRNA processing//regulation of transcription, DNA-templated//pathogenesis//'de novo' pyrimidine nucleobase biosynthetic process GO:0016987//GO:0003676//GO:0016491//GO:0003700//GO:0016765//GO:0070569//GO:0009055//GO:0050660//GO:0017150//GO:0004158//GO:0003677//GO:0016627//GO:0003919//GO:0051536//GO:0000150 sigma factor activity//nucleic acid binding//oxidoreductase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring alkyl or aryl (other than methyl) groups//uridylyltransferase activity//electron carrier activity//flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity//dihydroorotate oxidase activity//DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//FMN adenylyltransferase activity//iron-sulfur cluster binding//recombinase activity GO:0005667//GO:0043230//GO:0005737//GO:0009289 transcription factor complex//extracellular organelle//cytoplasm//pilus KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.36375 BF_2 144.14 0.47 13163 642920090 XP_008192200.1 2081 4.2e-230 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920089 XM_008193978.1 379 0 PREDICTED: Tribolium castaneum histone acetyltransferase Tip60 (LOC664310), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q5RBG4 1549 8.5e-170 Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 PF03719//PF13855//PF01853//PF00560//PF13508//PF00583//PF05261//PF00333 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//MOZ/SAS family//Leucine Rich Repeat//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//TraM protein, DNA-binding//Ribosomal protein S5, N-terminal domain GO:0042967//GO:0006412//GO:0042254//GO:0000746//GO:0006355 acyl-carrier-protein biosynthetic process//translation//ribosome biogenesis//conjugation//regulation of transcription, DNA-templated GO:0005515//GO:0008080//GO:0003677//GO:0003723//GO:0016747//GO:0003735 protein binding//N-acetyltransferase activity//DNA binding//RNA binding//transferase activity, transferring acyl groups other than amino-acyl groups//structural constituent of ribosome GO:0005634//GO:0005840 nucleus//ribosome KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.36376 BF_2 197.07 1.08 7895 642928815 XP_967995.2 1066 1.3e-112 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 9.1e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36377 BF_2 5689.02 200.18 1476 329762922 AEC04842.1 617 2.7e-61 chemosensory protein [Batocera horsfieldi] 329762921 HQ587040.1 393 0 Batocera horsfieldi chemosensory protein (CSP1) mRNA, complete cds -- -- -- -- Q9W1C9 283 6.0e-24 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36379 BF_2 180.73 8.73 1153 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36380 BF_2 1751.88 5.57 13452 642911254 XP_008199787.1 11406 0.0e+00 PREDICTED: filamin-A isoform X1 [Tribolium castaneum] 642911253 XM_008201565.1 2003 0 PREDICTED: Tribolium castaneum filamin-A (LOC661488), transcript variant X1, mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q9VEN1 5214 0.0e+00 Filamin-A OS=Drosophila melanogaster GN=cher PE=1 SV=2 PF01105//PF07859//PF00688//PF00307 emp24/gp25L/p24 family/GOLD//alpha/beta hydrolase fold//TGF-beta propeptide//Calponin homology (CH) domain GO:0008283//GO:0006810//GO:0040007//GO:0008152//GO:0007165 cell proliferation//transport//growth//metabolic process//signal transduction GO:0005515//GO:0008083//GO:0016787 protein binding//growth factor activity//hydrolase activity GO:0016021 integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.36381 BF_2 6504.18 94.35 3171 642926068 XP_008194752.1 4230 0.0e+00 PREDICTED: calsyntenin-1 [Tribolium castaneum] 759049730 XM_011335629.1 160 1.63607e-75 PREDICTED: Cerapachys biroi calsyntenin-1 (LOC105277343), transcript variant X2, mRNA -- -- -- -- Q9V498 1781 2.6e-197 Calsyntenin-1 OS=Drosophila melanogaster GN=Cals PE=1 SV=2 PF07953//PF00722//PF00028 Clostridium neurotoxin, N-terminal receptor binding//Glycosyl hydrolases family 16//Cadherin domain GO:0007165//GO:0009405//GO:0007156//GO:0051609//GO:0005975 signal transduction//pathogenesis//homophilic cell adhesion via plasma membrane adhesion molecules//inhibition of neurotransmitter uptake//carbohydrate metabolic process GO:0004553//GO:0004222//GO:0005509//GO:0050827 hydrolase activity, hydrolyzing O-glycosyl compounds//metalloendopeptidase activity//calcium ion binding//toxin receptor binding GO:0016020//GO:0005576 membrane//extracellular region KOG1834 Calsyntenin Cluster-8309.36382 BF_2 67237.00 396.49 7381 507228 AAA64736.1 693 2.1e-69 apolipophorin-III, partial [Derobrachus geminatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00430//PF05866//PF06667//PF04108//PF05823//PF00804//PF07464//PF03623//PF10280//PF05478//PF06008//PF01442//PF05531//PF02993//PF06109//PF10150//PF01474//PF06320//PF14942//PF04799//PF04513//PF02601 ATP synthase B/B' CF(0)//Endodeoxyribonuclease RusA//Phage shock protein B//Autophagy protein Apg17//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Syntaxin//Apolipophorin-III precursor (apoLp-III)//Focal adhesion targeting region//Mediator complex protein//Prominin//Laminin Domain I//Apolipoprotein A1/A4/E domain//Nucleopolyhedrovirus P10 protein//Minor capsid protein VI//Haemolysin E (HlyE)//Ribonuclease E/G family//Class-II DAHP synthetase family//GCN5-like protein 1 (GCN5L1)//Organelle biogenesis, Muted-like protein//fzo-like conserved region//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit GO:0008053//GO:0006310//GO:0000162//GO:0009073//GO:0007172//GO:0006357//GO:0045995//GO:0015992//GO:0006571//GO:0015986//GO:0030155//GO:0009094//GO:0006308//GO:0042157//GO:0006869//GO:0006355//GO:0009271//GO:0044179//GO:0030334//GO:0007165//GO:0009405//GO:0006281//GO:0006914//GO:0006468 mitochondrial fusion//DNA recombination//tryptophan biosynthetic process//aromatic amino acid family biosynthetic process//signal complex assembly//regulation of transcription from RNA polymerase II promoter//regulation of embryonic development//proton transport//tyrosine biosynthetic process//ATP synthesis coupled proton transport//regulation of cell adhesion//L-phenylalanine biosynthetic process//DNA catabolic process//lipoprotein metabolic process//lipid transport//regulation of transcription, DNA-templated//phage shock//hemolysis in other organism//regulation of cell migration//signal transduction//pathogenesis//DNA repair//autophagy//protein phosphorylation GO:0001104//GO:0008289//GO:0005102//GO:0003924//GO:0004871//GO:0000287//GO:0004713//GO:0003723//GO:0008855//GO:0015078//GO:0003849//GO:0005198 RNA polymerase II transcription cofactor activity//lipid binding//receptor binding//GTPase activity//signal transducer activity//magnesium ion binding//protein tyrosine kinase activity//RNA binding//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//3-deoxy-7-phosphoheptulonate synthase activity//structural molecule activity GO:0031083//GO:0016592//GO:0009318//GO:0005925//GO:0019028//GO:0016020//GO:0005576//GO:0005741//GO:0030133//GO:0019031//GO:0045263//GO:0016021 BLOC-1 complex//mediator complex//exodeoxyribonuclease VII complex//focal adhesion//viral capsid//membrane//extracellular region//mitochondrial outer membrane//transport vesicle//viral envelope//proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.36383 BF_2 18188.00 856.97 1175 270007633 EFA04081.1 228 2.8e-16 hypothetical protein TcasGA2_TC014315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36385 BF_2 4060.00 123.18 1666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14631//PF01080//PF04931//PF03286//PF06327//PF00527//PF15351 Fanconi anaemia protein FancD2 nuclease//Presenilin//DNA polymerase phi//Pox virus Ag35 surface protein//Domain of Unknown Function (DUF1053)//E7 protein, Early protein//Junctional protein associated with coronary artery disease GO:0006260//GO:0006355//GO:0006281//GO:0006351//GO:0006171//GO:0006144 DNA replication//regulation of transcription, DNA-templated//DNA repair//transcription, DNA-templated//cAMP biosynthetic process//purine nucleobase metabolic process GO:0003700//GO:0004016//GO:0004190//GO:0003677//GO:0003887 transcription factor activity, sequence-specific DNA binding//adenylate cyclase activity//aspartic-type endopeptidase activity//DNA binding//DNA-directed DNA polymerase activity GO:0005911//GO:0016021//GO:0042575//GO:0005886//GO:0019031//GO:0005667 cell-cell junction//integral component of membrane//DNA polymerase complex//plasma membrane//viral envelope//transcription factor complex -- -- Cluster-8309.36386 BF_2 1394.00 85.15 972 91077774 XP_968953.1 1181 7.2e-127 PREDICTED: ribosome biogenesis protein NSA2 homolog [Tribolium castaneum]>gi|270002241|gb|EEZ98688.1| hypothetical protein TcasGA2_TC001224 [Tribolium castaneum] 758274572 KP073488.1 271 9.6712e-138 Heliconius hermathena voucher 94_15 hairy cell leukemia protein (Hcl) gene, partial cds K14842 NSA2 ribosome biogenesis protein NSA2 http://www.genome.jp/dbget-bin/www_bget?ko:K14842 Q3SX11 1009 2.6e-108 Ribosome biogenesis protein NSA2 homolog OS=Bos taurus GN=NSA2 PE=2 SV=1 PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0016310//GO:0009069//GO:0006468 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005096//GO:0004674 GTPase activator activity//protein serine/threonine kinase activity -- -- KOG3163 Uncharacterized conserved protein related to ribosomal protein S8E Cluster-8309.36387 BF_2 1523.13 55.03 1445 91082025 XP_970311.1 727 4.7e-74 PREDICTED: vacuolar protein sorting-associated protein VTA1 homolog [Tribolium castaneum]>gi|270007383|gb|EFA03831.1| hypothetical protein TcasGA2_TC013947 [Tribolium castaneum] -- -- -- -- -- K12199 VTA1, LIP5 vacuolar protein sorting-associated protein VTA1 http://www.genome.jp/dbget-bin/www_bget?ko:K12199 Q32L63 544 3.2e-54 Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus GN=VTA1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0917 Uncharacterized conserved protein Cluster-8309.36389 BF_2 739.57 4.35 7402 642939440 XP_008200392.1 4003 0.0e+00 PREDICTED: maternal protein pumilio isoform X5 [Tribolium castaneum] 642939439 XM_008202170.1 661 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X5, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF00806//PF02422//PF08144 Pumilio-family RNA binding repeat//Keratin//CPL (NUC119) domain -- -- GO:0005200//GO:0003723 structural constituent of cytoskeleton//RNA binding GO:0005882//GO:0005856 intermediate filament//cytoskeleton KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.36390 BF_2 305.56 2.54 5319 91082899 XP_972170.1 2591 1.2e-289 PREDICTED: protein spire [Tribolium castaneum]>gi|270008222|gb|EFA04670.1| spire [Tribolium castaneum] 770075505 NM_001305498.1 122 3.66884e-54 Plutella xylostella translationally-controlled tumor protein homolog (LOC105389397), mRNA >gnl|BL_ORD_ID|1274647 Plutella xylostella mRNA for translationally controlled tumor protein, complete cds K02098 SPIR spire http://www.genome.jp/dbget-bin/www_bget?ko:K02098 Q75VN3 776 1.5e-80 Translationally-controlled tumor protein homolog OS=Bombyx mori GN=Tctp PE=2 SV=1 PF02205//PF00130 WH2 motif//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0003779 actin binding -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.36391 BF_2 636.00 439.59 342 91077564 XP_972465.1 296 1.1e-24 PREDICTED: muscle-specific protein 20 isoform X2 [Tribolium castaneum]>gi|270002170|gb|EEZ98617.1| hypothetical protein TcasGA2_TC001139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14318 176 3.6e-12 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain GO:0031032 actomyosin structure organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG2046 Calponin Cluster-8309.36392 BF_2 60136.49 1351.89 2148 50982101 AAT91723.1 445 3.5e-41 LIM protein [Apriona germari] 50982100 AY703482.1 453 0 Apriona germari muscle LIM protein mRNA, complete cds K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 P53777 359 1.4e-32 Muscle LIM protein 1 OS=Drosophila melanogaster GN=Mlp60A PE=2 SV=1 PF00412//PF00643//PF00096//PF03119 LIM domain//B-box zinc finger//Zinc finger, C2H2 type//NAD-dependent DNA ligase C4 zinc finger domain GO:0006260//GO:0006281 DNA replication//DNA repair GO:0003911//GO:0008270//GO:0046872 DNA ligase (NAD+) activity//zinc ion binding//metal ion binding GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36393 BF_2 38.57 2.07 1068 50982101 AAT91723.1 433 4.3e-40 LIM protein [Apriona germari] 50982100 AY703482.1 236 3.04923e-118 Apriona germari muscle LIM protein mRNA, complete cds K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 P53777 359 6.7e-33 Muscle LIM protein 1 OS=Drosophila melanogaster GN=Mlp60A PE=2 SV=1 PF00643//PF00412//PF03119//PF00096 B-box zinc finger//LIM domain//NAD-dependent DNA ligase C4 zinc finger domain//Zinc finger, C2H2 type GO:0006281//GO:0006260 DNA repair//DNA replication GO:0046872//GO:0008270//GO:0003911 metal ion binding//zinc ion binding//DNA ligase (NAD+) activity GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36394 BF_2 55027.70 243.47 9742 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 553 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 1.9e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF00651//PF04513//PF13639//PF04566//PF10588//PF14634//PF00643//PF01601//PF03884//PF00097//PF08165//PF01436 BTB/POZ domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//zinc-RING finger domain//B-box zinc finger//Coronavirus S2 glycoprotein//Domain of unknown function (DUF329)//Zinc finger, C3HC4 type (RING finger)//FerA (NUC095) domain//NHL repeat GO:0006206//GO:0061025//GO:0046813//GO:0006351//GO:0006144//GO:0055114 pyrimidine nucleobase metabolic process//membrane fusion//receptor-mediated virion attachment to host cell//transcription, DNA-templated//purine nucleobase metabolic process//oxidation-reduction process GO:0046872//GO:0003677//GO:0005515//GO:0016491//GO:0008270//GO:0003899//GO:0005198 metal ion binding//DNA binding//protein binding//oxidoreductase activity//zinc ion binding//DNA-directed RNA polymerase activity//structural molecule activity GO:0019031//GO:0005622//GO:0005730//GO:0016021//GO:0019028 viral envelope//intracellular//nucleolus//integral component of membrane//viral capsid KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.36395 BF_2 11901.00 47.69 10727 642918534 XP_008191512.1 790 1.7e-80 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 425 1.5e-39 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36397 BF_2 919.49 7.22 5615 270005127 EFA01575.1 1872 3.1e-206 hypothetical protein TcasGA2_TC007136 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1544 1.4e-169 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412//PF00643//PF03119//PF00096 LIM domain//B-box zinc finger//NAD-dependent DNA ligase C4 zinc finger domain//Zinc finger, C2H2 type GO:0006281//GO:0006260 DNA repair//DNA replication GO:0046872//GO:0003911//GO:0008270 metal ion binding//DNA ligase (NAD+) activity//zinc ion binding GO:0005622 intracellular KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36398 BF_2 1345.12 8.22 7133 478257467 ENN77623.1 2412 9.5e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 123 1.36971e-54 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 3.3e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF00097//PF00408//PF14634//PF15965//PF02880//PF00076//PF13639//PF02879//PF02878 Zinc finger, C3HC4 type (RING finger)//Phosphoglucomutase/phosphomannomutase, C-terminal domain//zinc-RING finger domain//TRAF-like zinc-finger//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ring finger domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0005975//GO:0071704 carbohydrate metabolic process//organic substance metabolic process GO:0005515//GO:0046872//GO:0016868//GO:0003676//GO:0008270 protein binding//metal ion binding//intramolecular transferase activity, phosphotransferases//nucleic acid binding//zinc ion binding -- -- KOG0625 Phosphoglucomutase Cluster-8309.36399 BF_2 70.53 0.79 4035 642913173 XP_008201422.1 537 1.4e-51 PREDICTED: uncharacterized protein LOC663955 isoform X1 [Tribolium castaneum] 642913177 XM_008203202.1 165 3.46762e-78 PREDICTED: Tribolium castaneum uncharacterized LOC663955 (LOC663955), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF10384 Centromere protein Scm3 -- -- GO:0042393 histone binding GO:0005634 nucleus -- -- Cluster-8309.36400 BF_2 6993.66 200.96 1743 332376523 AEE63401.1 2173 1.2e-241 unknown [Dendroctonus ponderosae]>gi|478249799|gb|ENN70306.1| hypothetical protein YQE_12817, partial [Dendroctonus ponderosae]>gi|546682880|gb|ERL92766.1| hypothetical protein D910_10075 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38942 975 4.1e-104 4-hydroxybutyrate coenzyme A transferase OS=Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) GN=cat2 PE=3 SV=3 PF02550 Acetyl-CoA hydrolase/transferase N-terminal domain GO:0006084 acetyl-CoA metabolic process GO:0003824 catalytic activity -- -- KOG2828 Acetyl-CoA hydrolase Cluster-8309.36401 BF_2 1484.00 46.26 1629 332375552 AEE62917.1 807 2.8e-83 unknown [Dendroctonus ponderosae]>gi|478250658|gb|ENN71150.1| hypothetical protein YQE_12081, partial [Dendroctonus ponderosae]>gi|546677242|gb|ERL88111.1| hypothetical protein D910_05500 [Dendroctonus ponderosae] 170069759 XM_001869304.1 164 4.97281e-78 Culex quinquefasciatus NADH dehydrogenase iron-sulfur protein 7, mitochondrial, mRNA K03940 NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03940 P0CB83 655 4.9e-67 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial OS=Pongo abelii GN=NDUFS7 PE=2 SV=1 PF01058 NADH ubiquinone oxidoreductase, 20 Kd subunit GO:0055114 oxidation-reduction process GO:0051536 iron-sulfur cluster binding -- -- KOG1687 NADH-ubiquinone oxidoreductase, NUFS7/PSST/20 kDa subunit Cluster-8309.36402 BF_2 51233.00 5346.59 688 67527227 AAY68367.1 880 4.1e-92 muscle protein 20-like protein [Anoplophora glabripennis] 67527226 DQ067276.1 342 2.29178e-177 Anoplophora glabripennis muscle protein 20-like protein mRNA, complete cds -- -- -- -- P14318 714 3.0e-74 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.36403 BF_2 355.32 7.27 2332 270009742 EFA06190.1 2085 2.6e-231 hypothetical protein TcasGA2_TC009039 [Tribolium castaneum] -- -- -- -- -- K17043 DDX43 ATP-dependent RNA helicase DDX43 http://www.genome.jp/dbget-bin/www_bget?ko:K17043 Q9NXZ2 1382 3.5e-151 Probable ATP-dependent RNA helicase DDX43 OS=Homo sapiens GN=DDX43 PE=2 SV=2 PF00176//PF00013//PF04851//PF13014//PF00270//PF07650 SNF2 family N-terminal domain//KH domain//Type III restriction enzyme, res subunit//KH domain//DEAD/DEAH box helicase//KH domain -- -- GO:0003723//GO:0005524//GO:0003677//GO:0016787//GO:0003676 RNA binding//ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.36404 BF_2 16.44 0.33 2390 642920110 XP_008192209.1 1184 7.9e-127 PREDICTED: putative oxidoreductase GLYR1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q161 831 2.8e-87 Putative oxidoreductase GLYR1 homolog OS=Anopheles gambiae GN=AGAP009949 PE=3 SV=5 PF14833//PF03446//PF16519 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//NAD binding domain of 6-phosphogluconate dehydrogenase//Tetramerisation domain of TRPM GO:0019521//GO:0006098//GO:0051262//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//protein tetramerization//oxidation-reduction process GO:0004616//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding -- -- KOG0409 Predicted dehydrogenase Cluster-8309.36405 BF_2 391292.68 6165.58 2942 91079989 XP_970719.1 3290 0.0e+00 PREDICTED: paramyosin, long form [Tribolium castaneum] 332374739 BT127549.1 1051 0 Dendroctonus ponderosae clone DPO0813_C03 unknown mRNA -- -- -- -- P35415 2724 1.1e-306 Paramyosin, long form OS=Drosophila melanogaster GN=Prm PE=1 SV=1 PF00038//PF01576//PF05221//PF00015 Intermediate filament protein//Myosin tail//S-adenosyl-L-homocysteine hydrolase//Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0007165//GO:0006555//GO:0006730 signal transduction//methionine metabolic process//one-carbon metabolic process GO:0005198//GO:0004013//GO:0003774//GO:0004871 structural molecule activity//adenosylhomocysteinase activity//motor activity//signal transducer activity GO:0005882//GO:0016459//GO:0016020 intermediate filament//myosin complex//membrane KOG0161 Myosin class II heavy chain Cluster-8309.36406 BF_2 101.33 1.65 2862 642922794 XP_008193328.1 2003 1.0e-221 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 5.1e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF08496//PF06905//PF11965//PF03357 Peptidase family S49 N-terminal//Fas apoptotic inhibitory molecule (FAIM1)//Domain of unknown function (DUF3479)//Snf7 GO:0007034//GO:0015994//GO:0043066 vacuolar transport//chlorophyll metabolic process//negative regulation of apoptotic process GO:0016851//GO:0004252 magnesium chelatase activity//serine-type endopeptidase activity GO:0005886//GO:0010007 plasma membrane//magnesium chelatase complex -- -- Cluster-8309.36408 BF_2 3937.77 32.68 5327 642939071 XP_008200210.1 2291 7.6e-255 PREDICTED: DEAD-box ATP-dependent RNA helicase 20-like isoform X1 [Tribolium castaneum] 158300605 XM_320481.4 215 7.35819e-106 Anopheles gambiae str. PEST AGAP012045-PA (AgaP_AGAP012045) mRNA, complete cds K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1374 6.7e-150 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF04851//PF01019//PF00816//PF00270 Type III restriction enzyme, res subunit//Gamma-glutamyltranspeptidase//H-NS histone family//DEAD/DEAH box helicase GO:0006691//GO:0006355//GO:0006693//GO:0019530//GO:0006749 leukotriene metabolic process//regulation of transcription, DNA-templated//prostaglandin metabolic process//taurine metabolic process//glutathione metabolic process GO:0003840//GO:0003676//GO:0005524//GO:0016787//GO:0003677 gamma-glutamyltransferase activity//nucleic acid binding//ATP binding//hydrolase activity//DNA binding GO:0005622 intracellular KOG0331 ATP-dependent RNA helicase Cluster-8309.36409 BF_2 138.42 7.27 1084 91079768 XP_966889.1 329 5.0e-28 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 P15428 181 3.0e-12 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Homo sapiens GN=HPGD PE=1 SV=1 PF01370//PF01073//PF00106 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase GO:0008210//GO:0008152//GO:0008209//GO:0055114//GO:0006694//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0050662//GO:0003824//GO:0003854//GO:0000166 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//nucleotide binding -- -- -- -- Cluster-8309.36410 BF_2 142.60 18.08 617 332373768 AEE62025.1 482 5.1e-46 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q23997 353 1.9e-32 Chitinase-like protein CG5210 OS=Drosophila melanogaster GN=CG5210 PE=1 SV=2 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.36411 BF_2 999.00 8.59 5150 478257412 ENN77568.1 1668 1.3e-182 hypothetical protein YQE_05864, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9I7U4 1162 2.5e-125 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36412 BF_2 13841.00 435.07 1618 478253720 ENN74019.1 1457 1.2e-158 hypothetical protein YQE_09409, partial [Dendroctonus ponderosae]>gi|546685011|gb|ERL94576.1| hypothetical protein D910_11853 [Dendroctonus ponderosae] 528520776 XM_005170654.1 161 2.29766e-76 PREDICTED: Danio rerio solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3b (slc25a3b), transcript variant X1, mRNA K15102 SLC25A3, PHC, PIC solute carrier family 25 (mitochondrial phosphate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15102 P16036 1168 1.6e-126 Phosphate carrier protein, mitochondrial OS=Rattus norvegicus GN=Slc25a3 PE=1 SV=1 PF02405 Permease MlaE GO:0006810 transport -- -- GO:0043190 ATP-binding cassette (ABC) transporter complex KOG0767 Mitochondrial phosphate carrier protein Cluster-8309.36413 BF_2 41847.96 109.20 16318 642918534 XP_008191512.1 19534 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 3224 0 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 15939 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF14980//PF02502//PF05790//PF13895//PF02480 TIP39 peptide//Ribose/Galactose Isomerase//Immunoglobulin C2-set domain//Immunoglobulin domain//Alphaherpesvirus glycoprotein E GO:0007218//GO:0007155//GO:0005975 neuropeptide signaling pathway//cell adhesion//carbohydrate metabolic process GO:0005515//GO:0016853 protein binding//isomerase activity GO:0016021//GO:0016020//GO:0005576 integral component of membrane//membrane//extracellular region -- -- Cluster-8309.36414 BF_2 41998.11 1208.44 1741 270014971 EFA11419.1 1641 5.9e-180 hypothetical protein TcasGA2_TC013596 [Tribolium castaneum] 290048170 GU396008.1 405 0 Helicoverpa armigera arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 P48610 1581 2.2e-174 Arginine kinase OS=Drosophila melanogaster GN=Argk PE=2 SV=2 PF00217//PF02807 ATP:guanido phosphotransferase, C-terminal catalytic domain//ATP:guanido phosphotransferase, N-terminal domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.36415 BF_2 272.21 6.09 2157 332374576 AEE62429.1 1472 2.9e-160 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 295 9.96231e-151 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1258 7.7e-137 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- -- -- Cluster-8309.36416 BF_2 716.42 8.57 3786 642940096 XP_008192965.1 1556 9.2e-170 PREDICTED: paxillin isoform X6 [Tribolium castaneum]>gi|270016014|gb|EFA12462.1| hypothetical protein TcasGA2_TC010609 [Tribolium castaneum] 665811408 XM_008555945.1 200 1.13689e-97 PREDICTED: Microplitis demolitor leupaxin-like (LOC103575940), mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49024 851 2.1e-89 Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1 PF04216//PF03498//PF05923//PF00412 Protein involved in formate dehydrogenase formation//Cytolethal distending toxin A/C domain//APC cysteine-rich region//LIM domain GO:0016055//GO:0009405 Wnt signaling pathway//pathogenesis GO:0043169//GO:0008270 cation binding//zinc ion binding GO:0005737 cytoplasm KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.36418 BF_2 4230.21 34.81 5371 808128173 XP_012166984.1 2964 0.0e+00 PREDICTED: myosin heavy chain, muscle isoform X5 [Bombus terrestris] 642931316 XM_008198307.1 960 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2700 1.2e-303 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF08001//PF00063//PF02736//PF05060 CMV US//Myosin head (motor domain)//Myosin N-terminal SH3-like domain//N-acetylglucosaminyltransferase II (MGAT2) GO:0009312//GO:0030683 oligosaccharide biosynthetic process//evasion or tolerance by virus of host immune response GO:0005524//GO:0008455//GO:0003774 ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//motor activity GO:0016021//GO:0016459//GO:0005795//GO:0044386 integral component of membrane//myosin complex//Golgi stack//integral to host endoplasmic reticulum membrane KOG0161 Myosin class II heavy chain Cluster-8309.36420 BF_2 26228.00 1912.01 861 -- -- -- -- -- 359294281 JN986793.1 720 0 Batocera lineolata mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36421 BF_2 167.00 856.15 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01972//PF06624//PF10280 Serine dehydrogenase proteinase//Ribosome associated membrane protein RAMP4//Mediator complex protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0005783//GO:0016592//GO:0016021 endoplasmic reticulum//mediator complex//integral component of membrane -- -- Cluster-8309.36422 BF_2 340.63 13.17 1369 642930671 XP_008199218.1 636 1.6e-63 PREDICTED: uncharacterized protein LOC100142507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36423 BF_2 4611.69 51.58 4027 820857060 XP_012345672.1 1954 6.9e-216 PREDICTED: actin, clone 205-like isoform X1 [Apis florea] 55783599 AY817141.1 1112 0 Apriona germari actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41339 1911 2.7e-212 Actin, acrosomal process isoform OS=Limulus polyphemus PE=2 SV=1 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- KOG0676 Actin and related proteins Cluster-8309.36424 BF_2 60.32 1.05 2696 58294539 AAW70172.1 442 9.8e-41 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] -- -- -- -- -- -- -- -- -- Q02942 339 3.5e-30 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36425 BF_2 7233.98 513.05 877 557876145 AHA39267.1 585 8.3e-58 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36426 BF_2 1557.69 16.84 4157 546673641 ERL85205.1 1561 2.7e-170 hypothetical protein D910_02626 [Dendroctonus ponderosae] -- -- -- -- -- K17307 FBLN1_2 fibulin 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17307 O77469 617 3.2e-62 Fibulin-1 OS=Caenorhabditis elegans GN=fbl-1 PE=1 SV=3 PF04947//PF00008//PF07645//PF04814//PF00906//PF06247 Poxvirus Late Transcription Factor VLTF3 like//EGF-like domain//Calcium-binding EGF domain//Hepatocyte nuclear factor 1 (HNF-1), N terminus//Hepatitis core antigen//Plasmodium ookinete surface protein Pvs28 GO:0009405//GO:0046782//GO:0045893 pathogenesis//regulation of viral transcription//positive regulation of transcription, DNA-templated GO:0005198//GO:0005515//GO:0005509 structural molecule activity//protein binding//calcium ion binding GO:0005634//GO:0009986//GO:0016020 nucleus//cell surface//membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.36427 BF_2 14793.76 192.38 3504 820857060 XP_012345672.1 1954 6.0e-216 PREDICTED: actin, clone 205-like isoform X1 [Apis florea] 55783599 AY817141.1 1112 0 Apriona germari actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P41339 1911 2.4e-212 Actin, acrosomal process isoform OS=Limulus polyphemus PE=2 SV=1 PF16794 Fibronectin-III type domain -- -- GO:0005515 protein binding -- -- KOG0676 Actin and related proteins Cluster-8309.36428 BF_2 393.88 2.64 6536 642915533 XP_008190655.1 1572 2.2e-171 PREDICTED: tyrosine-protein phosphatase non-receptor type 61F isoform X1 [Tribolium castaneum] -- -- -- -- -- K18026 PTPN2, PTPT tyrosine-protein phosphatase non-receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18026 Q9W0G1 859 4.3e-90 Tyrosine-protein phosphatase non-receptor type 61F OS=Drosophila melanogaster GN=Ptp61F PE=1 SV=1 PF03119//PF00102//PF01396//PF00782//PF03248//PF08043 NAD-dependent DNA ligase C4 zinc finger domain//Protein-tyrosine phosphatase//Topoisomerase DNA binding C4 zinc finger//Dual specificity phosphatase, catalytic domain//Rer1 family//Xin repeat GO:0006570//GO:0006470//GO:0006281//GO:0030036//GO:0006265//GO:0006260 tyrosine metabolic process//protein dephosphorylation//DNA repair//actin cytoskeleton organization//DNA topological change//DNA replication GO:0003779//GO:0008138//GO:0004725//GO:0003916//GO:0003677//GO:0003911 actin binding//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//DNA topoisomerase activity//DNA binding//DNA ligase (NAD+) activity GO:0016021//GO:0005694//GO:0030054 integral component of membrane//chromosome//cell junction -- -- Cluster-8309.36429 BF_2 103.89 1.58 3033 91079134 XP_975446.1 877 4.0e-91 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|642916464|ref|XP_008191038.1| PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270004224|gb|EFA00672.1| hypothetical protein TcasGA2_TC003549 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P80034 579 5.9e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- GO:0006561//GO:0055114//GO:0055129//GO:0006525 proline biosynthetic process//oxidation-reduction process//L-proline biosynthetic process//arginine metabolic process GO:0000166//GO:0004735 nucleotide binding//pyrroline-5-carboxylate reductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.36432 BF_2 3063.08 11.10 11830 642918413 XP_008191462.1 2554 5.4e-285 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|642918415|ref|XP_008191463.1| PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|270003254|gb|EEZ99701.1| hypothetical protein TcasGA2_TC002462 [Tribolium castaneum] 642931619 XM_966443.2 176 7.84696e-84 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 P50416 1642 1.3e-180 Carnitine O-palmitoyltransferase 1, liver isoform OS=Homo sapiens GN=CPT1A PE=1 SV=2 PF00755//PF01532 Choline/Carnitine o-acyltransferase//Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571//GO:0016746 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2430 Glycosyl hydrolase, family 47 Cluster-8309.36435 BF_2 4621.00 127.69 1801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05808 Podoplanin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36436 BF_2 39.28 0.33 5218 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF01926//PF00983//PF03144 Elongation factor G, domain IV//50S ribosome-binding GTPase//Tymovirus coat protein//Elongation factor Tu domain 2 -- -- GO:0005525//GO:0005198 GTP binding//structural molecule activity GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.36439 BF_2 17144.65 155.38 4903 642935120 XP_008197896.1 5408 0.0e+00 PREDICTED: vigilin [Tribolium castaneum]>gi|270013832|gb|EFA10280.1| hypothetical protein TcasGA2_TC012484 [Tribolium castaneum] 642935119 XM_008199674.1 989 0 PREDICTED: Tribolium castaneum vigilin (LOC658150), mRNA -- -- -- -- Q00341 3389 0.0e+00 Vigilin OS=Homo sapiens GN=HDLBP PE=1 SV=2 PF00013//PF13014//PF13184//PF07650 KH domain//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2208 Vigilin Cluster-8309.36440 BF_2 1778.08 28.79 2871 91090794 XP_976004.1 328 1.7e-27 PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 1 [Tribolium castaneum]>gi|642935947|ref|XP_008198242.1| PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 1 [Tribolium castaneum] 642935946 XM_008200020.1 74 9.48974e-28 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q5KSL6 146 9.0e-08 Diacylglycerol kinase kappa OS=Homo sapiens GN=DGKK PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36441 BF_2 36170.77 120.48 12846 478258253 ENN78382.1 12264 0.0e+00 hypothetical protein YQE_05183, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 1476 2.4e-161 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF00041//PF00010//PF00069//PF06293//PF05038//PF07714 Immunoglobulin domain//Fibronectin type III domain//Helix-loop-helix DNA-binding domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Cytochrome Cytochrome b558 alpha-subunit//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0004672//GO:0020037//GO:0005524//GO:0005515//GO:0046983 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//heme binding//ATP binding//protein binding//protein dimerization activity GO:0016020 membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.36443 BF_2 45204.90 3080.68 901 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36444 BF_2 259.07 1.12 9945 270013942 EFA10390.1 1611 1.0e-175 hypothetical protein TcasGA2_TC012621 [Tribolium castaneum] 642935672 XM_969594.3 364 0 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 11 (LOC663555), mRNA K03036 PSMD11, RPN6 26S proteasome regulatory subunit N6 http://www.genome.jp/dbget-bin/www_bget?ko:K03036 Q7KLV9 1341 8.5e-146 26S proteasome non-ATPase regulatory subunit 11 OS=Drosophila melanogaster GN=Rpn6 PE=1 SV=1 PF01399//PF05524 PCI domain//PEP-utilising enzyme, N-terminal GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515 protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.36445 BF_2 77683.00 471.79 7175 478250665 ENN71157.1 3127 0.0e+00 hypothetical protein YQE_12088, partial [Dendroctonus ponderosae] 642931311 XM_001813763.2 1529 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X26, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2919 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00769//PF00038//PF01576//PF09177//PF00487 Ezrin/radixin/moesin family//Intermediate filament protein//Myosin tail//Syntaxin 6, N-terminal//Fatty acid desaturase GO:0006629//GO:0048193 lipid metabolic process//Golgi vesicle transport GO:0003774//GO:0005198//GO:0008092 motor activity//structural molecule activity//cytoskeletal protein binding GO:0005737//GO:0016020//GO:0005882//GO:0019898//GO:0016459 cytoplasm//membrane//intermediate filament//extrinsic component of membrane//myosin complex -- -- Cluster-8309.36447 BF_2 757.61 6.62 5078 642938278 XP_008192712.1 3186 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 988 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 Q08CW1 1818 2.1e-201 Serine/threonine-protein kinase tousled-like 2 OS=Xenopus tropicalis GN=tlk2 PE=2 SV=1 PF12142//PF07714//PF00069 Polyphenol oxidase middle domain//Protein tyrosine kinase//Protein kinase domain GO:0006118//GO:0055114//GO:0006468//GO:0006570 obsolete electron transport//oxidation-reduction process//protein phosphorylation//tyrosine metabolic process GO:0005524//GO:0004097//GO:0004672 ATP binding//catechol oxidase activity//protein kinase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.36451 BF_2 202.00 2.86 3241 91089087 XP_971707.1 1963 5.0e-217 PREDICTED: uncharacterized protein LOC660378 [Tribolium castaneum]>gi|270011517|gb|EFA07965.1| hypothetical protein TcasGA2_TC005547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXG1 131 5.6e-06 Zinc finger protein hangover OS=Drosophila melanogaster GN=hang PE=1 SV=3 PF05485//PF07776 THAP domain//Zinc-finger associated domain (zf-AD) -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.36452 BF_2 380.00 5.75 3054 332373100 AEE61691.1 1619 3.7e-177 unknown [Dendroctonus ponderosae] 632980128 XM_007908668.1 273 2.40398e-138 PREDICTED: Callorhinchus milii casein kinase 2, alpha 1 polypeptide (csnk2a1), mRNA K03097 CSNK2A casein kinase II subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03097 O76484 1565 2.8e-172 Casein kinase II subunit alpha OS=Spodoptera frugiperda PE=2 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0668 Casein kinase II, alpha subunit Cluster-8309.36453 BF_2 24.60 0.99 1331 91083393 XP_967983.1 860 1.6e-89 PREDICTED: 60S ribosomal protein L8 [Tribolium castaneum]>gi|642923889|ref|XP_008193915.1| PREDICTED: 60S ribosomal protein L8 [Tribolium castaneum]>gi|270006898|gb|EFA03346.1| hypothetical protein TcasGA2_TC013327 [Tribolium castaneum] 401828841 JX122920.1 261 4.83855e-132 Phaedon cochleariae ribosomal protein L8 mRNA, partial cds K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 Q95V39 783 5.7e-82 60S ribosomal protein L8 OS=Spodoptera frugiperda GN=RpL8 PE=2 SV=1 PF03947//PF00181 Ribosomal Proteins L2, C-terminal domain//Ribosomal Proteins L2, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2309 60s ribosomal protein L2/L8 Cluster-8309.36454 BF_2 33.51 0.51 3042 642911248 XP_008199756.1 2618 5.3e-293 PREDICTED: polyadenylate-binding protein 1 isoform X1 [Tribolium castaneum] 642911247 XM_008201534.1 472 0 PREDICTED: Tribolium castaneum polyadenylate-binding protein 1 (LOC657776), transcript variant X1, mRNA K13126 PABPC polyadenylate-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13126 Q9EPH8 1835 1.3e-203 Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1 PF00076//PF16367//PF00658 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Poly-adenylate binding protein, unique domain -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-8309.36455 BF_2 5496.23 202.25 1424 270005507 EFA01955.1 789 3.0e-81 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93113 612 4.1e-62 Glutathione S-transferase 1, isoform D OS=Anopheles gambiae GN=GstD1 PE=1 SV=1 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36456 BF_2 130062.23 4027.73 1638 571516260 XP_006569195.1 224 1.1e-15 PREDICTED: histidine-rich glycoprotein-like [Apis mellifera] -- -- -- -- -- -- -- -- -- P04929 188 6.9e-13 Histidine-rich glycoprotein OS=Plasmodium lophurae PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36458 BF_2 24.00 0.41 2749 642919398 XP_974094.3 1011 1.0e-106 PREDICTED: uncharacterized protein LOC662932 [Tribolium castaneum] 642919397 XM_969001.3 103 6.8729e-44 PREDICTED: Tribolium castaneum uncharacterized LOC662932 (LOC662932), mRNA -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36459 BF_2 26192.95 3291.70 620 642925601 XP_001812139.2 238 1.0e-17 PREDICTED: uncharacterized protein LOC660114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46162 188 2.6e-13 Serine protease inhibitor I/II OS=Schistocerca gregaria PE=1 SV=1 PF06872//PF00093//PF05375 EspG protein//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII) GO:0006508//GO:0009405 proteolysis//pathogenesis GO:0005515//GO:0030414//GO:0004197 protein binding//peptidase inhibitor activity//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.36460 BF_2 222.09 13.81 960 478259825 ENN79651.1 864 4.1e-90 hypothetical protein YQE_03910, partial [Dendroctonus ponderosae] -- -- -- -- -- K01697 E4.2.1.22, CBS cystathionine beta-synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01697 P32232 674 1.8e-69 Cystathionine beta-synthase OS=Rattus norvegicus GN=Cbs PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1252 Cystathionine beta-synthase and related enzymes Cluster-8309.36461 BF_2 6171.94 757.44 628 91087257 XP_975530.1 818 5.7e-85 PREDICTED: 60S ribosomal protein L12 [Tribolium castaneum]>gi|270010582|gb|EFA07030.1| hypothetical protein TcasGA2_TC010002 [Tribolium castaneum] -- -- -- -- -- K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 E2RR58 704 3.9e-73 60S ribosomal protein L12 OS=Canis familiaris GN=RPL12 PE=1 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-8309.36463 BF_2 209.69 4.65 2173 642915179 XP_008190507.1 362 1.5e-31 PREDICTED: uncharacterized protein LOC659076 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36466 BF_2 117066.77 1558.69 3429 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1125 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF00983//PF01926//PF03144//PF03764 Tymovirus coat protein//50S ribosome-binding GTPase//Elongation factor Tu domain 2//Elongation factor G, domain IV -- -- GO:0005198//GO:0005525 structural molecule activity//GTP binding GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.36467 BF_2 16.08 0.31 2488 478258940 ENN78915.1 990 2.6e-104 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q8CHP8 494 3.5e-48 Phosphoglycolate phosphatase OS=Mus musculus GN=Pgp PE=1 SV=1 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.36468 BF_2 1759.00 24.50 3290 478259697 ENN79541.1 1119 3.8e-119 hypothetical protein YQE_04004, partial [Dendroctonus ponderosae]>gi|546672024|gb|ERL84084.1| hypothetical protein D910_01418 [Dendroctonus ponderosae]>gi|546679827|gb|ERL90219.1| hypothetical protein D910_07572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P10379 415 6.6e-39 Protein unzipped OS=Drosophila melanogaster GN=uzip PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36469 BF_2 556.44 7.18 3531 91090882 XP_973170.1 1390 1.5e-150 PREDICTED: death-associated protein kinase related [Tribolium castaneum] 665818146 XM_008559662.1 44 5.55977e-11 PREDICTED: Microplitis demolitor serine/threonine-protein kinase 17B-like (LOC103578532), mRNA K08804 STK17 serine/threonine kinase 17 http://www.genome.jp/dbget-bin/www_bget?ko:K08804 Q0KHT7 743 6.6e-77 Death-associated protein kinase related OS=Drosophila melanogaster GN=Drak PE=1 SV=2 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.36471 BF_2 41.51 0.35 5256 270012222 EFA08670.1 2246 1.2e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03007//PF06974 Wax ester synthase-like Acyl-CoA acyltransferase domain//Protein of unknown function (DUF1298) GO:0042967//GO:0046486//GO:0045017 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process//glycerolipid biosynthetic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.36472 BF_2 12.57 0.78 965 282165794 NP_001164136.1 473 8.9e-45 chickadee [Tribolium castaneum] 282165793 NM_001170665.1 164 2.90536e-78 Tribolium castaneum chickadee (chic), mRNA K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 Q6QEJ7 446 4.9e-43 Profilin OS=Apis mellifera PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1755 Profilin Cluster-8309.36473 BF_2 8.00 2.81 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36474 BF_2 1636.06 10.53 6788 478252889 ENN73274.1 4014 0.0e+00 hypothetical protein YQE_10104, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.3e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025//PF14604//PF00018 Phage protein C//Variant SH3 domain//SH3 domain GO:0019073 viral DNA genome packaging GO:0005515 protein binding -- -- -- -- Cluster-8309.36476 BF_2 140.20 2.37 2761 91079244 XP_971138.1 1563 1.0e-170 PREDICTED: dnaJ homolog subfamily C member 22 [Tribolium castaneum]>gi|270003554|gb|EFA00002.1| hypothetical protein TcasGA2_TC002805 [Tribolium castaneum] -- -- -- -- -- K19370 DNAJC22 DnaJ homolog subfamily C member 22 http://www.genome.jp/dbget-bin/www_bget?ko:K19370 A9ULE9 305 3.2e-26 DnaJ homolog subfamily C member 22 OS=Xenopus tropicalis GN=dnajc22 PE=2 SV=1 PF01757 Acyltransferase family GO:0006457 protein folding GO:0031072//GO:0051082//GO:0016747 heat shock protein binding//unfolded protein binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.36477 BF_2 13351.00 1317.69 711 91084049 XP_967339.1 995 1.9e-105 PREDICTED: 40S ribosomal protein S8 [Tribolium castaneum]>gi|270008005|gb|EFA04453.1| hypothetical protein TcasGA2_TC014757 [Tribolium castaneum] 642924821 XM_962246.3 329 3.99801e-170 PREDICTED: Tribolium castaneum 40S ribosomal protein S8 (LOC655685), mRNA K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 O76756 908 9.7e-97 40S ribosomal protein S8 OS=Apis mellifera GN=RpS8 PE=2 SV=2 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3283 40S ribosomal protein S8 Cluster-8309.36478 BF_2 228.61 4.92 2229 642915179 XP_008190507.1 362 1.5e-31 PREDICTED: uncharacterized protein LOC659076 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36479 BF_2 255.57 49.05 505 669214630 CDW61305.1 215 3.8e-15 hypothetical protein TTRE_0000975601 [Trichuris trichiura] 296882003 HM046546.1 462 0 Lamiomimus gottschei voucher CNE1029 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 187 2.8e-13 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36480 BF_2 2291.76 27.18 3815 642913883 XP_975200.2 1600 7.3e-175 PREDICTED: forkhead box protein O isoform X1 [Tribolium castaneum] 642913882 XM_970107.2 416 0 PREDICTED: Tribolium castaneum forkhead box protein O (LOC664090), transcript variant X1, mRNA K09408 FOXO3 forkhead box protein O3 http://www.genome.jp/dbget-bin/www_bget?ko:K09408 B4MB78 974 1.2e-103 Forkhead box protein O OS=Drosophila virilis GN=foxo PE=3 SV=1 PF01342//PF00250 SAND domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.36482 BF_2 41.48 8.72 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.36483 BF_2 66.81 0.37 7753 642912688 XP_008200962.1 1566 1.3e-170 PREDICTED: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1 [Tribolium castaneum]>gi|270002375|gb|EEZ98822.1| hypothetical protein TcasGA2_TC004428 [Tribolium castaneum] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1223 3.2e-132 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF00005//PF04851//PF00270//PF10662//PF01096//PF14532//PF06068//PF05496//PF00437//PF07724//PF02367//PF02562//PF00503//PF07728//PF01695//PF00158//PF01057//PF00004 ABC transporter//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Ethanolamine utilisation - propanediol utilisation//Transcription factor S-II (TFIIS)//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//G-protein alpha subunit//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0002949//GO:0006457//GO:0006351//GO:0006576//GO:0007186//GO:0006355//GO:0007165//GO:0019079//GO:0006281//GO:0006810 DNA recombination//tRNA threonylcarbamoyladenosine modification//protein folding//transcription, DNA-templated//cellular biogenic amine metabolic process//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//signal transduction//viral genome replication//DNA repair//transport GO:0004871//GO:0003676//GO:0017111//GO:0009378//GO:0003677//GO:0003678//GO:0019001//GO:0016887//GO:0051082//GO:0008270//GO:0016787//GO:0031683//GO:0005524//GO:0008134//GO:0003924 signal transducer activity//nucleic acid binding//nucleoside-triphosphatase activity//four-way junction helicase activity//DNA binding//DNA helicase activity//guanyl nucleotide binding//ATPase activity//unfolded protein binding//zinc ion binding//hydrolase activity//G-protein beta/gamma-subunit complex binding//ATP binding//transcription factor binding//GTPase activity GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.36484 BF_2 39.75 0.33 5337 478251222 ENN71696.1 1095 3.7e-116 hypothetical protein YQE_11619, partial [Dendroctonus ponderosae] 315115388 HQ424723.1 158 3.57863e-74 Euphydryas aurinia ribosomal protein S15 (RpS15) mRNA, complete cds K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 O65059 491 1.7e-47 40S ribosomal protein S15 OS=Picea mariana GN=RPS15 PE=2 SV=1 PF04145//PF00654//PF00203 Ctr copper transporter family//Voltage gated chloride channel//Ribosomal protein S19 GO:0055085//GO:0006412//GO:0006825//GO:0006821//GO:0035434//GO:0042254 transmembrane transport//translation//copper ion transport//chloride transport//copper ion transmembrane transport//ribosome biogenesis GO:0005247//GO:0003735//GO:0005375 voltage-gated chloride channel activity//structural constituent of ribosome//copper ion transmembrane transporter activity GO:0016021//GO:0016020//GO:0005840 integral component of membrane//membrane//ribosome KOG0898 40S ribosomal protein S15 Cluster-8309.36485 BF_2 7878.50 215.86 1814 264667333 ACY71252.1 883 4.8e-92 ribosomal protein L17 [Chrysomela tremula] -- -- -- -- -- K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 Q4GXH6 855 3.5e-90 60S ribosomal protein L17 OS=Biphyllus lunatus GN=RpL17 PE=2 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-8309.36486 BF_2 1251.09 36.78 1710 549438535 AGX25156.1 1856 6.8e-205 thiol-disulfide isomerase [Leptinotarsa decemlineata] 157137765 XM_001663984.1 131 1.15539e-59 Aedes aegypti AAEL013845-RA partial mRNA K17264 ERP44, TXNDC4 endoplasmic reticulum resident protein 44 http://www.genome.jp/dbget-bin/www_bget?ko:K17264 Q9D1Q6 1046 2.3e-112 Endoplasmic reticulum resident protein 44 OS=Mus musculus GN=Erp44 PE=1 SV=1 PF01216//PF00085 Calsequestrin//Thioredoxin GO:0045454 cell redox homeostasis GO:0005509 calcium ion binding -- -- KOG0912 Thiol-disulfide isomerase and thioredoxin Cluster-8309.36488 BF_2 323.04 4.47 3310 570341948 AHE77372.1 614 1.4e-60 small heat shock protein [Lissorhoptrus oryzophilus] 570341961 KC620429.1 60 6.64258e-20 Lissorhoptrus oryzophilus small heat shock protein (HSP27e) mRNA, partial cds K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 351 1.8e-31 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF01873//PF00525//PF09066 Domain found in IF2B/IF5//Alpha crystallin A chain, N terminal//Beta2-adaptin appendage, C-terminal sub-domain GO:0006413//GO:0006886//GO:0006446//GO:0016192//GO:0007423 translational initiation//intracellular protein transport//regulation of translational initiation//vesicle-mediated transport//sensory organ development GO:0005212//GO:0003743 structural constituent of eye lens//translation initiation factor activity GO:0005840//GO:0030131 ribosome//clathrin adaptor complex -- -- Cluster-8309.36489 BF_2 1006.83 14.75 3143 189235372 XP_968511.2 1112 2.3e-118 PREDICTED: nucleobindin-2 [Tribolium castaneum]>gi|270004247|gb|EFA00695.1| hypothetical protein TcasGA2_TC003574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80303 492 7.5e-48 Nucleobindin-2 OS=Homo sapiens GN=NUCB2 PE=1 SV=2 PF13202//PF13499//PF13833//PF13405//PF00036 EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG3866 DNA-binding protein of the nucleobindin family Cluster-8309.36490 BF_2 138100.00 4585.55 1547 726971106 AIY53682.1 702 4.0e-71 myosin regulatory light chain 2 [Monochamus alternatus] 726971105 KM371003.1 567 0 Monochamus alternatus clone WHJ1 myosin regulatory light chain 2 mRNA, complete cds K12754 MYL7 myosin regulatory light chain 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12754 Q1HPS0 533 6.5e-53 Myosin regulatory light chain 2 OS=Bombyx mori PE=1 SV=1 PF13499//PF00036//PF13833//PF13405//PF13202 EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.36491 BF_2 129.29 2325.69 219 291170320 ADD82416.1 364 8.7e-33 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 202 4.38814e-100 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF00018 SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36492 BF_2 3806.41 141.69 1411 156481748 ABU68467.1 1247 2.3e-134 adenine nucleotide translocase [Monochamus alternatus] 156481747 EU093076.1 798 0 Monochamus alternatus adenine nucleotide translocase mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q26365 1142 1.4e-123 ADP,ATP carrier protein OS=Drosophila melanogaster GN=sesB PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.36493 BF_2 120.32 1.06 5034 332374740 AEE62511.1 2915 0.0e+00 unknown [Dendroctonus ponderosae] 332374739 BT127549.1 862 0 Dendroctonus ponderosae clone DPO0813_C03 unknown mRNA -- -- -- -- P35415 2329 1.2e-260 Paramyosin, long form OS=Drosophila melanogaster GN=Prm PE=1 SV=1 PF06009//PF01576//PF06160//PF04136//PF05221//PF05557//PF07730//PF08328 Laminin Domain II//Myosin tail//Septation ring formation regulator, EzrA//Sec34-like family//S-adenosyl-L-homocysteine hydrolase//Mitotic checkpoint protein//Histidine kinase//Adenylosuccinate lyase C-terminal GO:0006886//GO:0000160//GO:0006730//GO:0006531//GO:0006144//GO:0000921//GO:0016310//GO:0009152//GO:0006188//GO:0006555//GO:0007155//GO:0006522//GO:0007094 intracellular protein transport//phosphorelay signal transduction system//one-carbon metabolic process//aspartate metabolic process//purine nucleobase metabolic process//septin ring assembly//phosphorylation//purine ribonucleotide biosynthetic process//IMP biosynthetic process//methionine metabolic process//cell adhesion//alanine metabolic process//mitotic spindle assembly checkpoint GO:0004018//GO:0000155//GO:0004013//GO:0046983//GO:0003774 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity//phosphorelay sensor kinase activity//adenosylhomocysteinase activity//protein dimerization activity//motor activity GO:0005940//GO:0016021//GO:0016459//GO:0005801//GO:0009365//GO:0016020 septin ring//integral component of membrane//myosin complex//cis-Golgi network//protein histidine kinase complex//membrane KOG0161 Myosin class II heavy chain Cluster-8309.36496 BF_2 7875.20 411.37 1088 282165794 NP_001164136.1 635 1.6e-63 chickadee [Tribolium castaneum] 282165793 NM_001170665.1 275 6.49427e-140 Tribolium castaneum chickadee (chic), mRNA K05759 PFN profilin http://www.genome.jp/dbget-bin/www_bget?ko:K05759 Q6QEJ7 603 3.5e-61 Profilin OS=Apis mellifera PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1755 Profilin Cluster-8309.36497 BF_2 191.52 5.36 1781 642935906 XP_008198223.1 2248 2.5e-250 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2098 2.5e-234 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF09264//PF08437//PF00122 Vibrio cholerae sialidase, lectin insertion//Glycosyl transferase family 8 C-terminal//E1-E2 ATPase GO:0009103 lipopolysaccharide biosynthetic process GO:0008918//GO:0046872//GO:0033691//GO:0000166 lipopolysaccharide 3-alpha-galactosyltransferase activity//metal ion binding//sialic acid binding//nucleotide binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.36498 BF_2 330.70 2.65 5516 642926413 XP_008191952.1 2921 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X1 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.63803e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 4.1e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.36499 BF_2 7010.68 134.42 2469 478257427 ENN77583.1 2448 2.2e-273 hypothetical protein YQE_05879, partial [Dendroctonus ponderosae]>gi|546685706|gb|ERL95167.1| hypothetical protein D910_12436 [Dendroctonus ponderosae] -- -- -- -- -- K00294 E1.2.1.88 1-pyrroline-5-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00294 P30038 1718 4.0e-190 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial OS=Homo sapiens GN=ALDH4A1 PE=1 SV=3 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- KOG2455 Delta-1-pyrroline-5-carboxylate dehydrogenase Cluster-8309.36500 BF_2 4993.04 77.94 2967 478249731 ENN70239.1 482 2.5e-45 hypothetical protein YQE_13023, partial [Dendroctonus ponderosae]>gi|546677413|gb|ERL88250.1| hypothetical protein D910_05638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y639 172 9.0e-11 Neuroplastin OS=Homo sapiens GN=NPTN PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36501 BF_2 19.00 8.05 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36502 BF_2 958.76 6.23 6730 270002717 EEZ99164.1 9016 0.0e+00 hypothetical protein TcasGA2_TC016163 [Tribolium castaneum] 642912219 XM_965461.2 1695 0 PREDICTED: Tribolium castaneum putative U5 small nuclear ribonucleoprotein 200 kDa helicase (LOC659129), mRNA K12854 SNRNP200, BRR2 pre-mRNA-splicing helicase BRR2 http://www.genome.jp/dbget-bin/www_bget?ko:K12854 Q9VUV9 8008 0.0e+00 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Drosophila melanogaster GN=l(3)72Ab PE=2 SV=4 PF00270//PF00437//PF00580//PF01695//PF04851//PF03146//PF02562 DEAD/DEAH box helicase//Type II/IV secretion system protein//UvrD/REP helicase N-terminal domain//IstB-like ATP binding protein//Type III restriction enzyme, res subunit//Agrin NtA domain//PhoH-like protein GO:0006810//GO:0007213//GO:0043113 transport//G-protein coupled acetylcholine receptor signaling pathway//receptor clustering GO:0043236//GO:0003677//GO:0016787//GO:0005524//GO:0003676 laminin binding//DNA binding//hydrolase activity//ATP binding//nucleic acid binding -- -- KOG0951 RNA helicase BRR2, DEAD-box superfamily Cluster-8309.36503 BF_2 3971.17 34.17 5149 642915997 XP_008190849.1 3679 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O01761 593 2.4e-59 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF15202//PF06220//PF13895//PF00041 Adipogenin//U1 zinc finger//Immunoglobulin domain//Fibronectin type III domain GO:0045444 fat cell differentiation GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.36504 BF_2 12.00 0.67 1042 -- -- -- -- -- 690280870 CP009459.1 418 0 Cedecea neteri strain ND14a, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36505 BF_2 5338.00 17.35 13156 642923233 XP_008193668.1 6238 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 7 isoform X4 [Tribolium castaneum] 642923232 XM_008195446.1 999 0 PREDICTED: Tribolium castaneum chromodomain-helicase-DNA-binding protein 7 (LOC659010), transcript variant X4, mRNA K14437 CHD7 chromodomain-helicase-DNA-binding protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14437 A2AJK6 2939 0.0e+00 Chromodomain-helicase-DNA-binding protein 7 OS=Mus musculus GN=Chd7 PE=1 SV=1 PF08074//PF00176//PF07533//PF04851 CHDCT2 (NUC038) domain//SNF2 family N-terminal domain//BRK domain//Type III restriction enzyme, res subunit GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016817//GO:0016818//GO:0016787//GO:0003677//GO:0005524//GO:0005515 zinc ion binding//hydrolase activity, acting on acid anhydrides//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrolase activity//DNA binding//ATP binding//protein binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.36507 BF_2 3263.79 39.80 3718 642918852 XP_008191614.1 1788 1.1e-196 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76329 167 4.3e-10 Interaptin OS=Dictyostelium discoideum GN=abpD PE=1 SV=1 PF04434//PF01414 SWIM zinc finger//Delta serrate ligand GO:0007154 cell communication GO:0008270 zinc ion binding GO:0016020 membrane -- -- Cluster-8309.36509 BF_2 678.63 41.09 978 91084843 XP_966905.1 740 9.9e-76 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 328 2.4e-29 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.36510 BF_2 7101.23 79.67 4016 91084051 XP_967428.1 4787 0.0e+00 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BKC5 2861 0.0e+00 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF02985//PF09044//PF01602//PF00514 HEAT repeat//Kp4//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0006886//GO:0016192//GO:0009405 intracellular protein transport//vesicle-mediated transport//pathogenesis GO:0005515 protein binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.36514 BF_2 2515.66 20.32 5466 642934860 XP_971174.2 3111 0.0e+00 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] 198472181 XM_001355830.2 178 2.79396e-85 Drosophila pseudoobscura pseudoobscura GA11069 (Dpse\GA11069), partial mRNA K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 2572 8.4e-289 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00175//PF00258//PF00667 Oxidoreductase NAD-binding domain//Flavodoxin//FAD binding domain GO:0055114 oxidation-reduction process GO:0010181//GO:0016491 FMN binding//oxidoreductase activity -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.36516 BF_2 822.67 7.09 5138 642919375 XP_008191845.1 3479 0.0e+00 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P53767 852 2.2e-89 Vascular endothelial growth factor receptor 1 OS=Rattus norvegicus GN=Flt1 PE=2 SV=1 PF00069//PF07714//PF02480//PF13895//PF01325 Protein kinase domain//Protein tyrosine kinase//Alphaherpesvirus glycoprotein E//Immunoglobulin domain//Iron dependent repressor, N-terminal DNA binding domain GO:0006468 protein phosphorylation GO:0003677//GO:0005524//GO:0004672//GO:0005515 DNA binding//ATP binding//protein kinase activity//protein binding GO:0016020 membrane -- -- Cluster-8309.36517 BF_2 11603.47 27.05 18233 642929802 XP_008195983.1 16014 0.0e+00 PREDICTED: dynein heavy chain, cytoplasmic isoform X2 [Tribolium castaneum] 642929801 XM_008197761.1 3152 0 PREDICTED: Tribolium castaneum dynein heavy chain (LOC664489), transcript variant X2, mRNA K10413 DYNC1H dynein heavy chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10413 P37276 14288 0.0e+00 Dynein heavy chain, cytoplasmic OS=Drosophila melanogaster GN=Dhc64C PE=2 SV=2 PF08702//PF04513//PF00910//PF02477//PF00005//PF07926//PF03767//PF01496//PF03028//PF06810//PF13851//PF00437//PF06009//PF12106//PF07851//PF06008//PF01580//PF10473//PF06160//PF02932//PF00004//PF04111//PF05791//PF07728//PF01695 Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//RNA helicase//Nucleocapsid N protein//ABC transporter//TPR/MLP1/MLP2-like protein//HAD superfamily, subfamily IIIB (Acid phosphatase)//V-type ATPase 116kDa subunit family//Dynein heavy chain and region D6 of dynein motor//Phage minor structural protein GP20//Growth-arrest specific micro-tubule binding//Type II/IV secretion system protein//Laminin Domain II//Colicin C terminal ribonuclease domain//TMPIT-like protein//Laminin Domain I//FtsK/SpoIIIE family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Neurotransmitter-gated ion-channel transmembrane region//ATPase family associated with various cellular activities (AAA)//Autophagy protein Apg6//Bacillus haemolytic enterotoxin (HBL)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006771//GO:0030168//GO:0000921//GO:0048870//GO:0006606//GO:0045995//GO:0015992//GO:0019497//GO:0007155//GO:0030155//GO:0006811//GO:0015991//GO:0007017//GO:0051252//GO:0007165//GO:0009405//GO:0007018//GO:0030334//GO:0006810//GO:0051258//GO:0006914 riboflavin metabolic process//platelet activation//septin ring assembly//cell motility//protein import into nucleus//regulation of embryonic development//proton transport//hexachlorocyclohexane metabolic process//cell adhesion//regulation of cell adhesion//ion transport//ATP hydrolysis coupled proton transport//microtubule-based process//regulation of RNA metabolic process//signal transduction//pathogenesis//microtubule-based movement//regulation of cell migration//transport//protein polymerization//autophagy GO:0030674//GO:0003777//GO:0005102//GO:0016887//GO:0003993//GO:0005524//GO:0008134//GO:0045502//GO:0042803//GO:0003724//GO:0003677//GO:0003723//GO:0015078//GO:0000166//GO:0004540//GO:0005198 protein binding, bridging//microtubule motor activity//receptor binding//ATPase activity//acid phosphatase activity//ATP binding//transcription factor binding//dynein binding//protein homodimerization activity//RNA helicase activity//DNA binding//RNA binding//hydrogen ion transmembrane transporter activity//nucleotide binding//ribonuclease activity//structural molecule activity GO:0030286//GO:0005667//GO:0005577//GO:0019013//GO:0019028//GO:0016020//GO:0033179//GO:0019031//GO:0005874//GO:0031514//GO:0016021//GO:0005940 dynein complex//transcription factor complex//fibrinogen complex//viral nucleocapsid//viral capsid//membrane//proton-transporting V-type ATPase, V0 domain//viral envelope//microtubule//motile cilium//integral component of membrane//septin ring KOG3595 Dyneins, heavy chain Cluster-8309.36519 BF_2 405.44 1.75 10003 642934185 XP_008199643.1 2538 3.3e-283 PREDICTED: uncharacterized protein LOC657682 isoform X4 [Tribolium castaneum] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 1.7e-215 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF00130//PF10510//PF17095//PF07649//PF00628//PF00183//PF05192//PF04857 Phorbol esters/diacylglycerol binding domain (C1 domain)//Phosphatidylinositol-glycan biosynthesis class S protein//Spectrin-binding region of Ca2+-Calmodulin//C1-like domain//PHD-finger//Hsp90 protein//MutS domain III//CAF1 family ribonuclease GO:0016255//GO:0006298//GO:0006950//GO:0006457//GO:0031175//GO:0055114//GO:0035556 attachment of GPI anchor to protein//mismatch repair//response to stress//protein folding//neuron projection development//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0030507//GO:0005524//GO:0005516//GO:0047134//GO:0051082//GO:0030983 protein binding//spectrin binding//ATP binding//calmodulin binding//protein-disulfide reductase activity//unfolded protein binding//mismatched DNA binding GO:0005634//GO:0042765//GO:0008091 nucleus//GPI-anchor transamidase complex//spectrin KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.36520 BF_2 124.99 2.20 2662 546674950 ERL86223.1 2220 6.5e-247 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 1.00893e-111 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1683 5.0e-186 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF00390//PF03949 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain GO:0006099//GO:0015976//GO:0006090//GO:0055114//GO:0006108 tricarboxylic acid cycle//carbon utilization//pyruvate metabolic process//oxidation-reduction process//malate metabolic process GO:0004471//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.36522 BF_2 79.63 0.89 4020 546676342 ERL87369.1 696 5.1e-70 hypothetical protein D910_04764 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.36523 BF_2 113.02 0.99 5069 642917533 XP_008191243.1 1126 8.9e-120 PREDICTED: myosin-3 [Tribolium castaneum] 462291896 APGK01053945.1 99 2.13356e-41 Dendroctonus ponderosae Seq01053955, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36524 BF_2 15097.80 113.23 5865 642935884 XP_008198212.1 3942 0.0e+00 PREDICTED: sterile alpha and TIR motif-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IDD9 2775 1.9e-312 Sterile alpha and TIR motif-containing protein 1 OS=Drosophila melanogaster GN=Ect4 PE=2 SV=1 PF07647//PF00536//PF06624//PF00514//PF13676 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Ribosome associated membrane protein RAMP4//Armadillo/beta-catenin-like repeat//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG3678 SARM protein (with sterile alpha and armadillo motifs) Cluster-8309.36526 BF_2 49394.00 1418.32 1744 780036326 XP_011667444.1 2193 5.8e-244 PREDICTED: tubulin alpha-1 chain-like [Strongylocentrotus purpuratus] 155573639 EU073050.1 1093 0 Monochamus alternatus alpha-tubulin 1 mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q9JJZ2 2057 1.4e-229 Tubulin alpha-8 chain OS=Mus musculus GN=Tuba8 PE=1 SV=1 PF13912//PF00091 C2H2-type zinc finger//Tubulin/FtsZ family, GTPase domain -- -- GO:0003924//GO:0046872 GTPase activity//metal ion binding -- -- KOG1376 Alpha tubulin Cluster-8309.36527 BF_2 15807.13 51.66 13086 478258253 ENN78382.1 13121 0.0e+00 hypothetical protein YQE_05183, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 1476 2.5e-161 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00010//PF00041//PF13895//PF05038//PF00069//PF06293//PF07714 Helix-loop-helix DNA-binding domain//Fibronectin type III domain//Immunoglobulin domain//Cytochrome Cytochrome b558 alpha-subunit//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0020037//GO:0004672//GO:0005524//GO:0046983//GO:0005515 phosphotransferase activity, alcohol group as acceptor//heme binding//protein kinase activity//ATP binding//protein dimerization activity//protein binding GO:0016020 membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.36528 BF_2 134.34 1.82 3371 642914172 XP_008201574.1 2306 8.8e-257 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 952 3.7e-101 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738//PF15182 Dienelactone hydrolase family//Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.36529 BF_2 176.71 3.85 2206 270002097 EEZ98544.1 592 3.2e-58 hypothetical protein TcasGA2_TC001048 [Tribolium castaneum] 642913817 XM_008202950.1 217 2.33472e-107 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12751 MYL6 myosin light chain 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12751 Q24654 425 3.1e-40 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF13405 EF-hand domain pair//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.36530 BF_2 92.67 0.45 8862 642924959 XP_008194115.1 2763 2.4e-309 PREDICTED: coiled-coil domain-containing protein CG32809 isoform X7 [Tribolium castaneum] 642924968 XM_008195898.1 229 2.0242e-113 PREDICTED: Tribolium castaneum coiled-coil domain-containing protein AGAP005037 (LOC100141714), transcript variant X12, mRNA -- -- -- -- Q7PQ25 1220 8.1e-132 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF07945//PF02970//PF07989//PF15724//PF01025 Janus-atracotoxin//Tubulin binding cofactor A//Centrosomin N-terminal motif 1//TMEM119 family//GrpE GO:0009405//GO:0001503//GO:0006457//GO:0007021 pathogenesis//ossification//protein folding//tubulin complex assembly GO:0015631//GO:0051087//GO:0051082//GO:0042803//GO:0000774 tubulin binding//chaperone binding//unfolded protein binding//protein homodimerization activity//adenyl-nucleotide exchange factor activity GO:0045298//GO:0005815//GO:0005576 tubulin complex//microtubule organizing center//extracellular region -- -- Cluster-8309.36532 BF_2 20314.90 281.04 3311 678336953 CDW75723.1 506 4.6e-48 UNKNOWN [Stylonychia lemnae] 375005309 JN619131.1 1522 0 Pogonocherus hispidulus voucher BMNH:835571 18S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36535 BF_2 7972.35 79.41 4487 642919149 XP_008191757.1 5346 0.0e+00 PREDICTED: phosphoribosylformylglycinamidine synthase-like [Tribolium castaneum] 703110936 XM_010101429.1 38 1.53267e-07 Morus notabilis putative phosphoribosylformylglycinamidine synthase partial mRNA K01952 purL, PFAS phosphoribosylformylglycinamidine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01952 P35421 3627 0.0e+00 Phosphoribosylformylglycinamidine synthase OS=Drosophila melanogaster GN=ade2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1907 Phosphoribosylformylglycinamidine synthase Cluster-8309.36536 BF_2 30499.75 1111.55 1435 642924457 XP_008194306.1 1652 2.6e-181 PREDICTED: 60S ribosomal protein L4 [Tribolium castaneum]>gi|270006788|gb|EFA03236.1| hypothetical protein TcasGA2_TC013168 [Tribolium castaneum] 70909604 AM048989.1 303 2.34729e-155 Eucinetus sp. APV-2005 mRNA for ribosomal protein L4e (rpL4e gene) K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P09180 1314 1.6e-143 60S ribosomal protein L4 OS=Drosophila melanogaster GN=RpL4 PE=1 SV=2 PF00573 Ribosomal protein L4/L1 family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.36539 BF_2 30798.77 602.37 2426 270014632 EFA11080.1 1673 1.6e-183 hypothetical protein TcasGA2_TC004676 [Tribolium castaneum] -- -- -- -- -- K05768 GSN gelsolin http://www.genome.jp/dbget-bin/www_bget?ko:K05768 Q07171 1086 7.6e-117 Gelsolin OS=Drosophila melanogaster GN=Gel PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0443 Actin regulatory proteins (gelsolin/villin family) Cluster-8309.36540 BF_2 25887.00 705.10 1823 385199964 AFI45030.1 1313 6.6e-142 cytochrome P450 CYP6CR2 [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 892 1.8e-94 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.36541 BF_2 47091.89 1931.65 1307 91089929 XP_973045.1 495 3.4e-47 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00436 Single-strand binding protein family -- -- GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.36543 BF_2 321748.00 2178.66 6465 556505467 YP_008757564.1 1815 1.5e-199 NADH dehydrogenase subunit 4 (mitochondrion) [Batocera lineolata]>gi|359294290|gb|AEV21659.1| NADH dehydrogenase subunit 4 [Batocera lineolata] 359294281 JN986793.1 5035 0 Batocera lineolata mitochondrion, complete genome K03881 ND4 NADH-ubiquinone oxidoreductase chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03881 P07707 1224 2.0e-132 NADH-ubiquinone oxidoreductase chain 4 OS=Drosophila yakuba GN=mt:ND4 PE=3 SV=1 PF00420//PF02272//PF06455//PF13965 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L//DHHA1 domain//NADH dehydrogenase subunit 5 C-terminus//dsRNA-gated channel SID-1 GO:0006120//GO:0042773//GO:0015931//GO:0033227//GO:0015992//GO:0055114//GO:0006744//GO:0006814 mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport//nucleobase-containing compound transport//dsRNA transport//proton transport//oxidation-reduction process//ubiquinone biosynthetic process//sodium ion transport GO:0016651//GO:0008137//GO:0003676//GO:0051033 oxidoreductase activity, acting on NAD(P)H//NADH dehydrogenase (ubiquinone) activity//nucleic acid binding//RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG4845 NADH dehydrogenase, subunit 4 Cluster-8309.36545 BF_2 20998.47 614.35 1717 33112583 AAP94047.1 1461 4.3e-159 cathepsin-L-like cysteine peptidase 03 [Tenebrio molitor] 33112582 AY332271.1 252 6.32425e-127 Tenebrio molitor cathepsin-L-like cysteine peptidase 03 mRNA, complete cds K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1253 2.3e-136 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF02347//PF00112//PF03051 Glycine cleavage system P-protein//Papain family cysteine protease//Peptidase C1-like family GO:0006546//GO:0006544//GO:0055114//GO:0006566//GO:0006508//GO:0006563 glycine catabolic process//glycine metabolic process//oxidation-reduction process//threonine metabolic process//proteolysis//L-serine metabolic process GO:0004197//GO:0004375//GO:0008234 cysteine-type endopeptidase activity//glycine dehydrogenase (decarboxylating) activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.36546 BF_2 232.58 0.93 10764 270001100 EEZ97547.1 2545 5.4e-284 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] 170032990 XM_001844311.1 225 4.11724e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 9.9e-217 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF01378//PF00412//PF13180//PF10468//PF00560//PF13855//PF00595//PF14304 B domain//LIM domain//PDZ domain//Carboxypeptidase inhibitor I68//Leucine Rich Repeat//Leucine rich repeat//PDZ domain (Also known as DHR or GLGF)//Transcription termination and cleavage factor C-terminal GO:0007596//GO:0031124//GO:0010951 blood coagulation//mRNA 3'-end processing//negative regulation of endopeptidase activity GO:0005515//GO:0008191//GO:0008270 protein binding//metalloendopeptidase inhibitor activity//zinc ion binding GO:0005618 cell wall KOG0619 FOG: Leucine rich repeat Cluster-8309.36547 BF_2 1558.68 66.41 1269 91086607 XP_973974.1 276 8.2e-22 PREDICTED: V-type proton ATPase subunit G [Tribolium castaneum]>gi|270009777|gb|EFA06225.1| hypothetical protein TcasGA2_TC009074 [Tribolium castaneum] -- -- -- -- -- K02152 ATPeV1G, ATP6G V-type H+-transporting ATPase subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K02152 Q25532 245 1.3e-19 V-type proton ATPase subunit G OS=Manduca sexta PE=3 SV=1 PF04857//PF14942//PF07464//PF03938//PF07851//PF04111 CAF1 family ribonuclease//Organelle biogenesis, Muted-like protein//Apolipophorin-III precursor (apoLp-III)//Outer membrane protein (OmpH-like)//TMPIT-like protein//Autophagy protein Apg6 GO:0006869//GO:0006914 lipid transport//autophagy GO:0008289//GO:0051082 lipid binding//unfolded protein binding GO:0005634//GO:0016021//GO:0005576//GO:0030133//GO:0031083 nucleus//integral component of membrane//extracellular region//transport vesicle//BLOC-1 complex KOG1772 Vacuolar H+-ATPase V1 sector, subunit G Cluster-8309.36548 BF_2 12578.37 226.82 2607 642920667 XP_008192513.1 828 1.6e-85 PREDICTED: tropomyosin-1, isoforms 33/34 isoform X5 [Tribolium castaneum] 642920666 XM_008194291.1 338 1.50771e-174 PREDICTED: Tribolium castaneum troponin I (LOC656510), transcript variant X5, mRNA -- -- -- -- P36188 522 2.1e-51 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF01529 Troponin//DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.36549 BF_2 342.61 2.70 5594 642935990 XP_008198259.1 4373 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1884 5.2e-209 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00632//PF00397 HECT-domain (ubiquitin-transferase)//WW domain GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.36551 BF_2 416.47 7.18 2712 642920676 XP_008192517.1 490 2.7e-46 PREDICTED: troponin I isoform X10 [Tribolium castaneum] 332376704 BT128535.1 118 3.10973e-52 Dendroctonus ponderosae clone DPO073_P08 unknown mRNA -- -- -- -- P36188 439 9.0e-42 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00832//PF00992 Ribosomal L39 protein//Troponin GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005861//GO:0005622//GO:0005840 troponin complex//intracellular//ribosome KOG3977 Troponin I Cluster-8309.36552 BF_2 466.39 8.05 2712 332374296 AEE62289.1 1127 3.7e-120 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 1.8e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.36554 BF_2 287.64 3.83 3430 642919704 XP_008192030.1 434 1.1e-39 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15925 SOSS complex subunit C GO:0006974//GO:0006281 cellular response to DNA damage stimulus//DNA repair GO:0016772 transferase activity, transferring phosphorus-containing groups GO:0070876//GO:0005634 SOSS complex//nucleus -- -- Cluster-8309.36556 BF_2 810.90 12.56 2987 642918139 XP_008191383.1 969 8.4e-102 PREDICTED: hepatic leukemia factor-like, partial [Tribolium castaneum] 462392704 APGK01017996.1 66 2.76596e-23 Dendroctonus ponderosae Seq01018006, whole genome shotgun sequence K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 357 3.2e-32 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF07716//PF00170//PF09726//PF03131 Basic region leucine zipper//bZIP transcription factor//Transmembrane protein//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.36557 BF_2 26738.99 287.48 4178 291170320 ADD82416.1 712 7.5e-72 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 402 0 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF01395//PF01384 PBP/GOBP family//Phosphate transporter family GO:0006817 phosphate ion transport GO:0005315//GO:0005549 inorganic phosphate transmembrane transporter activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.36558 BF_2 52.99 0.38 6087 642910289 XP_008198706.1 2334 9.0e-260 PREDICTED: U2 snRNP-associated SURP motif-containing protein-like [Tribolium castaneum] -- -- -- -- -- K12842 SR140 U2-associated protein SR140 http://www.genome.jp/dbget-bin/www_bget?ko:K12842 Q5R7X2 1542 2.5e-169 U2 snRNP-associated SURP motif-containing protein OS=Pongo abelii GN=U2SURP PE=2 SV=1 PF11051//PF01805//PF16367//PF01501//PF00076 Mannosyltransferase putative//Surp module//RNA recognition motif//Glycosyl transferase family 8//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006486//GO:0006396 protein glycosylation//RNA processing GO:0003676//GO:0016757//GO:0003723 nucleic acid binding//transferase activity, transferring glycosyl groups//RNA binding -- -- KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains Cluster-8309.36559 BF_2 320.41 5.94 2545 642926997 XP_008195097.1 2168 6.7e-241 PREDICTED: mitotic spindle assembly checkpoint protein MAD1 [Tribolium castaneum]>gi|270010044|gb|EFA06492.1| hypothetical protein TcasGA2_TC009389 [Tribolium castaneum] -- -- -- -- -- K06638 MAD1L mitotic spindle assembly checkpoint protein MAD1 http://www.genome.jp/dbget-bin/www_bget?ko:K06638 Q80YF0 486 3.0e-47 Mitotic spindle assembly checkpoint protein MAD1 OS=Cricetulus griseus GN=MAD1L1 PE=2 SV=1 PF00038//PF05557//PF08287 Intermediate filament protein//Mitotic checkpoint protein//Spc19 GO:0008608//GO:0007094 attachment of spindle microtubules to kinetochore//mitotic spindle assembly checkpoint GO:0005198 structural molecule activity GO:0042729//GO:0005882//GO:0005876 DASH complex//intermediate filament//spindle microtubule KOG4593 Mitotic checkpoint protein MAD1 Cluster-8309.36560 BF_2 5648.33 93.44 2816 91081945 XP_966990.1 2785 0.0e+00 PREDICTED: ATP-binding cassette sub-family F member 2 [Tribolium castaneum]>gi|270007325|gb|EFA03773.1| hypothetical protein TcasGA2_TC013884 [Tribolium castaneum] 642921870 XM_961897.3 497 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family F member 2 (LOC655357), mRNA K06185 ABCF2 ATP-binding cassette, subfamily F, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06185 Q9UG63 2156 7.5e-241 ATP-binding cassette sub-family F member 2 OS=Homo sapiens GN=ABCF2 PE=1 SV=2 PF01716//PF00025//PF00004//PF01926//PF13304//PF00910//PF03969//PF06414//PF03193//PF00005 Manganese-stabilising protein / photosystem II polypeptide//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//RNA helicase//AFG1-like ATPase//Zeta toxin//Protein of unknown function, DUF258//ABC transporter GO:0042549//GO:0015979//GO:0006200 photosystem II stabilization//photosynthesis//obsolete ATP catabolic process GO:0016301//GO:0016887//GO:0005525//GO:0005509//GO:0003724//GO:0005524//GO:0003723//GO:0003924 kinase activity//ATPase activity//GTP binding//calcium ion binding//RNA helicase activity//ATP binding//RNA binding//GTPase activity GO:0009654//GO:0009523//GO:0019898 photosystem II oxygen evolving complex//photosystem II//extrinsic component of membrane KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.36562 BF_2 1262.49 17.76 3261 546676387 ERL87409.1 794 1.8e-81 hypothetical protein D910_04804 [Dendroctonus ponderosae] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 594 1.2e-59 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF02558//PF02826//PF02882//PF12242//PF00106//PF08720//PF01370 Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//Influenza C hemagglutinin stalk//NAD dependent epimerase/dehydratase family GO:0009396//GO:0046487//GO:0015940//GO:0007165//GO:0055114//GO:0019064//GO:0008152 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//pantothenate biosynthetic process//signal transduction//oxidation-reduction process//fusion of virus membrane with host plasma membrane//metabolic process GO:0004488//GO:0050662//GO:0016491//GO:0051287//GO:0003824//GO:0046789//GO:0008677 methylenetetrahydrofolate dehydrogenase (NADP+) activity//coenzyme binding//oxidoreductase activity//NAD binding//catalytic activity//host cell surface receptor binding//2-dehydropantoate 2-reductase activity GO:0019031//GO:0009986 viral envelope//cell surface KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.36563 BF_2 1970.10 31.55 2899 332373528 AEE61905.1 891 9.1e-93 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06072 Alphaherpesvirus tegument protein US9 -- -- -- -- GO:0019033 viral tegument -- -- Cluster-8309.36564 BF_2 19386.27 355.09 2571 642934860 XP_971174.2 3111 0.0e+00 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] 198472181 XM_001355830.2 178 1.30529e-85 Drosophila pseudoobscura pseudoobscura GA11069 (Dpse\GA11069), partial mRNA K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 2572 3.9e-289 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00667//PF00258//PF00175 FAD binding domain//Flavodoxin//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.36565 BF_2 1081.84 9.71 4947 91082253 XP_973026.1 3234 0.0e+00 PREDICTED: elongation factor G, mitochondrial [Tribolium castaneum] 170040110 XM_001847803.1 291 3.85688e-148 Culex quinquefasciatus elongation factor G 1, mitochondrial, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 B4HY41 3037 0.0e+00 Elongation factor G, mitochondrial OS=Drosophila sechellia GN=ico PE=3 SV=1 PF03764//PF10461//PF00922//PF04548//PF03144//PF05485//PF01926 Elongation factor G, domain IV//Peptidase S68//Vesiculovirus phosphoprotein//AIG1 family//Elongation factor Tu domain 2//THAP domain//50S ribosome-binding GTPase GO:0006974//GO:0006144//GO:0006915 cellular response to DNA damage stimulus//purine nucleobase metabolic process//apoptotic process GO:0003968//GO:0005525//GO:0003676 RNA-directed RNA polymerase activity//GTP binding//nucleic acid binding GO:0031379 RNA-directed RNA polymerase complex KOG0465 Mitochondrial elongation factor Cluster-8309.36566 BF_2 47.09 0.38 5481 642936846 XP_008197874.1 3578 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase listerin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1C231 1009 1.5e-107 E3 ubiquitin-protein ligase listerin OS=Gallus gallus GN=LTN1 PE=3 SV=1 PF07022//PF00130//PF00097//PF00628//PF05225//PF16866//PF12678//PF12906//PF13639//PF12861 Bacteriophage CI repressor helix-turn-helix domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C3HC4 type (RING finger)//PHD-finger//helix-turn-helix, Psq domain//PHD-finger//RING-H2 zinc finger//RING-variant domain//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0045892//GO:0035556//GO:0016567 negative regulation of transcription, DNA-templated//intracellular signal transduction//protein ubiquitination GO:0008270//GO:0046872//GO:0003677//GO:0005515//GO:0004842 zinc ion binding//metal ion binding//DNA binding//protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0803 Predicted E3 ubiquitin ligase Cluster-8309.36567 BF_2 79.12 0.33 10372 642911194 XP_008199555.1 6749 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X2 [Tribolium castaneum] 805816096 XM_012293285.1 429 0 PREDICTED: Megachile rotundata inositol 1,4,5-trisphosphate receptor (LOC100879087), transcript variant X4, mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 5050 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF01365//PF00520//PF02815 RIH domain//Ion transport protein//MIR domain GO:0070588//GO:0006811//GO:0006816//GO:0055085 calcium ion transmembrane transport//ion transport//calcium ion transport//transmembrane transport GO:0005262//GO:0005216 calcium channel activity//ion channel activity GO:0016020 membrane KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.36568 BF_2 205.63 4.34 2269 642917912 XP_008191379.1 997 3.6e-105 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 504 2.2e-49 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.36569 BF_2 643.46 7.42 3915 91082211 XP_972371.1 1201 1.4e-128 PREDICTED: caspase-8 [Tribolium castaneum]>gi|270008200|gb|EFA04648.1| death related ced-3/Nedd2-like protein [Tribolium castaneum] -- -- -- -- -- K15275 SLC35B1 solute carrier family 35 (UDP-galactose transporter), member B1 http://www.genome.jp/dbget-bin/www_bget?ko:K15275 Q9VDD7 776 1.1e-80 Solute carrier family 35 member B1 homolog OS=Drosophila melanogaster GN=meigo PE=2 SV=1 PF00892//PF00656//PF08449 EamA-like transporter family//Caspase domain//UAA transporter family GO:0055085//GO:0006508 transmembrane transport//proteolysis GO:0004197 cysteine-type endopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1581 UDP-galactose transporter related protein Cluster-8309.36570 BF_2 58.46 1.07 2565 270014632 EFA11080.1 1673 1.7e-183 hypothetical protein TcasGA2_TC004676 [Tribolium castaneum] -- -- -- -- -- K05768 GSN gelsolin http://www.genome.jp/dbget-bin/www_bget?ko:K05768 Q07171 1086 8.1e-117 Gelsolin OS=Drosophila melanogaster GN=Gel PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0443 Actin regulatory proteins (gelsolin/villin family) Cluster-8309.36571 BF_2 4763.00 107.48 2141 646710816 KDR16234.1 415 1.1e-37 Alpha-actinin, sarcomeric [Zootermopsis nevadensis] 719734445 XM_010224358.1 41 1.55918e-09 PREDICTED: Tinamus guttatus actinin, alpha 1 (ACTN1), transcript variant X5, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 408 2.8e-38 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36573 BF_2 8088.55 327.61 1320 758213798 AJO62212.1 376 2.2e-33 chemosensory protein CSP6 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q9W1C9 294 2.9e-25 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01348//PF03283//PF05388 Type II intron maturase//Pectinacetylesterase//Carboxypeptidase Y pro-peptide GO:0006397 mRNA processing GO:0004185//GO:0016787 serine-type carboxypeptidase activity//hydrolase activity GO:0005773 vacuole -- -- Cluster-8309.36575 BF_2 1819.77 248.87 593 478259433 ENN79323.1 479 1.1e-45 hypothetical protein YQE_04232, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6UXI9 138 1.6e-07 Nephronectin OS=Homo sapiens GN=NPNT PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36576 BF_2 2190.63 50.97 2085 91085965 XP_971530.1 2068 2.2e-229 PREDICTED: protein ERGIC-53 [Tribolium castaneum]>gi|270010174|gb|EFA06622.1| hypothetical protein TcasGA2_TC009540 [Tribolium castaneum] -- -- -- -- -- K10080 LMAN1, ERGIC53 lectin, mannose-binding 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10080 Q9D0F3 1075 1.2e-115 Protein ERGIC-53 OS=Mus musculus GN=Lman1 PE=2 SV=1 PF08649//PF06320//PF00139//PF03388 DASH complex subunit Dad1//GCN5-like protein 1 (GCN5L1)//Legume lectin domain//Legume-like lectin family GO:0030472 mitotic spindle organization in nucleus GO:0030246 carbohydrate binding GO:0016020//GO:0072686//GO:0042729//GO:0031083 membrane//mitotic spindle//DASH complex//BLOC-1 complex KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.36577 BF_2 12.10 0.81 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36578 BF_2 487.78 2.63 8045 546681997 ERL91993.1 4107 0.0e+00 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2242 2.3e-250 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF06701//PF05456//PF09026 Mib_herc2//Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Centromere protein B dimerisation domain GO:0006355//GO:0016567//GO:0045947 regulation of transcription, DNA-templated//protein ubiquitination//negative regulation of translational initiation GO:0003682//GO:0008190//GO:0046872//GO:0004842//GO:0003677 chromatin binding//eukaryotic initiation factor 4E binding//metal ion binding//ubiquitin-protein transferase activity//DNA binding GO:0000775//GO:0000785//GO:0005634 chromosome, centromeric region//chromatin//nucleus KOG4276 Predicted hormone receptor interactor Cluster-8309.36579 BF_2 1319.00 42.98 1571 91086255 XP_966955.1 353 1.2e-30 PREDICTED: eukaryotic translation initiation factor 3 subunit J [Tribolium castaneum]>gi|270010259|gb|EFA06707.1| hypothetical protein TcasGA2_TC009638 [Tribolium castaneum] -- -- -- -- -- K03245 EIF3J translation initiation factor 3 subunit J http://www.genome.jp/dbget-bin/www_bget?ko:K03245 Q0ZB73 196 7.9e-14 Eukaryotic translation initiation factor 3 subunit J OS=Bombyx mori PE=2 SV=1 PF02724//PF01080//PF03176//PF08597 CDC45-like protein//Presenilin//MMPL family//Translation initiation factor eIF3 subunit GO:0006446//GO:0006270 regulation of translational initiation//DNA replication initiation GO:0004190//GO:0003743 aspartic-type endopeptidase activity//translation initiation factor activity GO:0016021//GO:0005840//GO:0016020//GO:0005852//GO:0005737 integral component of membrane//ribosome//membrane//eukaryotic translation initiation factor 3 complex//cytoplasm -- -- Cluster-8309.36580 BF_2 6009.00 141.39 2065 642911105 XP_008200579.1 3123 0.0e+00 PREDICTED: twitchin isoform X7 [Tribolium castaneum] 462386192 APGK01020323.1 230 1.29542e-114 Dendroctonus ponderosae Seq01020333, whole genome shotgun sequence -- -- -- -- Q23551 1384 1.8e-151 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF05506//PF16794//PF01108//PF16656//PF13895//PF00041 Domain of unknown function (DUF756)//Fibronectin-III type domain//Tissue factor//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0009395//GO:0006771//GO:0016042 hexachlorocyclohexane metabolic process//phospholipid catabolic process//riboflavin metabolic process//lipid catabolic process GO:0005515//GO:0004629//GO:0046872//GO:0003993 protein binding//phospholipase C activity//metal ion binding//acid phosphatase activity -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.36581 BF_2 118.49 2.76 2082 91084833 XP_966469.1 1077 1.8e-114 PREDICTED: inositol oxygenase [Tribolium castaneum]>gi|270008967|gb|EFA05415.1| hypothetical protein TcasGA2_TC015591 [Tribolium castaneum] -- -- -- -- -- K00469 MIOX inositol oxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00469 Q4V8T0 734 4.3e-76 Inositol oxygenase OS=Danio rerio GN=miox PE=2 SV=1 PF01075//PF05153//PF16622 Glycosyltransferase family 9 (heptosyltransferase)//Myo-inositol oxygenase//zinc-finger C2H2-type GO:0055114//GO:0008152//GO:0019310 oxidation-reduction process//metabolic process//inositol catabolic process GO:0050113//GO:0046872//GO:0005506//GO:0016757 inositol oxygenase activity//metal ion binding//iron ion binding//transferase activity, transferring glycosyl groups GO:0005737 cytoplasm KOG1573 Aldehyde reductase Cluster-8309.36582 BF_2 36.27 0.49 3410 678336953 CDW75723.1 594 2.9e-58 UNKNOWN [Stylonychia lemnae] 375005309 JN619131.1 1775 0 Pogonocherus hispidulus voucher BMNH:835571 18S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM5 140 5.3e-07 Putative uncharacterized protein ART3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART3 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36583 BF_2 4375.95 19.64 9609 642930353 XP_008196361.1 7185 0.0e+00 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] 462296961 APGK01052190.1 77 6.88457e-29 Dendroctonus ponderosae Seq01052200, whole genome shotgun sequence K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1372 2.1e-149 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 PF16954 Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0015886 heme transport GO:0015232 heme transporter activity -- -- KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.36584 BF_2 135.86 1.38 4412 642912998 XP_008201345.1 1240 4.7e-133 PREDICTED: synaptic vesicle glycoprotein 2C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q02563 204 2.6e-14 Synaptic vesicle glycoprotein 2A OS=Rattus norvegicus GN=Sv2a PE=1 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.36585 BF_2 39.84 2.50 954 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36586 BF_2 32.00 7.01 478 741829289 AJA91071.1 155 3.3e-08 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36590 BF_2 837.62 6.99 5299 189240885 XP_971484.2 5737 0.0e+00 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Tribolium castaneum] 347963318 XM_310958.5 1205 0 Anopheles gambiae str. PEST AGAP000178-PA (AgaP_AGAP000178) mRNA, complete cds K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 4943 0.0e+00 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 PF07571//PF01264//PF04162//PF04931//PF08064//PF02985 TAF6 C-terminal HEAT repeat domain//Chorismate synthase//Gyrovirus capsid protein (VP1)//DNA polymerase phi//UME (NUC010) domain//HEAT repeat GO:0009069//GO:0006571//GO:0006260//GO:0051090//GO:0016310//GO:0006351//GO:0009073//GO:0000162//GO:0009094 serine family amino acid metabolic process//tyrosine biosynthetic process//DNA replication//regulation of sequence-specific DNA binding transcription factor activity//phosphorylation//transcription, DNA-templated//aromatic amino acid family biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process GO:0004674//GO:0004107//GO:0003887//GO:0005515//GO:0003677 protein serine/threonine kinase activity//chorismate synthase activity//DNA-directed DNA polymerase activity//protein binding//DNA binding GO:0042575//GO:0019028//GO:0005634 DNA polymerase complex//viral capsid//nucleus KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.36592 BF_2 4682.73 159.80 1513 211939884 ACJ13424.1 872 7.6e-91 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- P80034 579 2.9e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36596 BF_2 10922.00 1446.42 603 91091798 XP_970498.1 621 3.8e-62 PREDICTED: 40S ribosomal protein S14 [Tribolium castaneum]>gi|642937302|ref|XP_008198777.1| PREDICTED: 40S ribosomal protein S14 [Tribolium castaneum]>gi|270000834|gb|EEZ97281.1| hypothetical protein TcasGA2_TC011085 [Tribolium castaneum] 620695572 KJ489363.1 220 1.31563e-109 Dastarcus helophoroides ribosomal protein mRNA, complete cds K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P14130 594 2.1e-60 40S ribosomal protein S14 OS=Drosophila melanogaster GN=RpS14a PE=1 SV=1 PF00411//PF03423 Ribosomal protein S11//Carbohydrate binding domain (family 25) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.36597 BF_2 659.25 12.45 2503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05309 TraE protein GO:0000746 conjugation -- -- -- -- -- -- Cluster-8309.36598 BF_2 246.57 5.72 2089 91077370 XP_975175.1 898 1.0e-93 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001655|gb|EEZ98102.1| hypothetical protein TcasGA2_TC000515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28493 580 3.1e-58 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36599 BF_2 217.00 2.68 3672 167444216 ABZ80669.1 216 2.1e-14 luxuriosin-like protein [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.36600 BF_2 2683.00 166.07 963 332374140 AEE62211.1 584 1.2e-57 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O76879 195 6.3e-14 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36601 BF_2 12969.73 147.80 3958 91077534 XP_967040.1 779 1.2e-79 PREDICTED: myophilin [Tribolium castaneum]>gi|270001583|gb|EEZ98030.1| hypothetical protein TcasGA2_TC000431 [Tribolium castaneum] 768423547 XM_011554383.1 125 5.85417e-56 PREDICTED: Plutella xylostella muscle-specific protein 20 (LOC105384189), mRNA -- -- -- -- P14318 417 4.7e-39 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain GO:0031032 actomyosin structure organization GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG2046 Calponin Cluster-8309.36602 BF_2 572.00 13.44 2068 478263346 ENN81724.1 822 6.5e-85 hypothetical protein YQE_01886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF00032 Oxaloacetate decarboxylase, gamma chain//Cytochrome b(C-terminal)/b6/petD GO:0071436//GO:0006090//GO:0006118//GO:0006814//GO:0006560//GO:0006525 sodium ion export//pyruvate metabolic process//obsolete electron transport//sodium ion transport//proline metabolic process//arginine metabolic process GO:0015081//GO:0009055//GO:0016491//GO:0008948 sodium ion transmembrane transporter activity//electron carrier activity//oxidoreductase activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.36603 BF_2 3155.81 35.18 4040 642933525 XP_008197455.1 393 7.1e-35 PREDICTED: protein alan shepard isoform X2 [Tribolium castaneum] 642933533 XM_008199237.1 55 4.88919e-17 PREDICTED: Tribolium castaneum protein alan shepard (LOC663083), transcript variant X7, mRNA -- -- -- -- B4LFQ9 132 5.3e-06 Protein alan shepard OS=Drosophila virilis GN=shep PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36604 BF_2 6067.46 177.89 1714 642912323 XP_969456.2 1349 4.2e-146 PREDICTED: aldose reductase [Tribolium castaneum] 523485322 KC007347.1 74 5.62197e-28 Agrotis ipsilon clone Unigene_1274 aldo-keto reductase mRNA, partial cds K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 951 2.4e-101 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.36605 BF_2 1064.78 63.02 994 642922790 XP_008193326.1 963 1.4e-101 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 382 1.3e-35 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.36606 BF_2 1426.58 10.00 6253 270007317 EFA03765.1 2164 4.8e-240 hypothetical protein TcasGA2_TC013876 [Tribolium castaneum] 642921924 XM_008194725.1 121 1.5521e-53 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 889 1.4e-93 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02020//PF05372//PF02854 eIF4-gamma/eIF5/eIF2-epsilon//Delta lysin family//MIF4G domain GO:0019836 hemolysis by symbiont of host erythrocytes GO:0003723//GO:0005515 RNA binding//protein binding GO:0005576 extracellular region KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.36609 BF_2 2856.00 19.02 6570 546685505 ERL95003.1 1008 5.6e-106 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 173 1.5e-10 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF01442//PF05478//PF00430//PF01544//PF07464//PF17078//PF02601//PF04513 Apolipoprotein A1/A4/E domain//Prominin//ATP synthase B/B' CF(0)//CorA-like Mg2+ transporter protein//Apolipophorin-III precursor (apoLp-III)//SWI5-dependent HO expression protein 3//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0015986//GO:0006308//GO:0042157//GO:0030001//GO:0048309//GO:0051028//GO:0006869//GO:0015992//GO:0055085 ATP synthesis coupled proton transport//DNA catabolic process//lipoprotein metabolic process//metal ion transport//endoplasmic reticulum inheritance//mRNA transport//lipid transport//proton transport//transmembrane transport GO:0046873//GO:0008289//GO:0008855//GO:0015078//GO:0005198 metal ion transmembrane transporter activity//lipid binding//exodeoxyribonuclease VII activity//hydrogen ion transmembrane transporter activity//structural molecule activity GO:0016020//GO:0005576//GO:0019031//GO:0045263//GO:0009318//GO:0016021//GO:0019028 membrane//extracellular region//viral envelope//proton-transporting ATP synthase complex, coupling factor F(o)//exodeoxyribonuclease VII complex//integral component of membrane//viral capsid -- -- Cluster-8309.36611 BF_2 72.77 0.47 6698 189237751 XP_001812575.1 3801 0.0e+00 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 9.9e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF04769//PF08070 PX domain//Mating-type protein MAT alpha 1 HMG-box//DTHCT (NUC029) region GO:0006265//GO:0045895//GO:0007531 DNA topological change//positive regulation of mating-type specific transcription, DNA-templated//mating type determination GO:0003918//GO:0008301//GO:0003677//GO:0005524//GO:0035091 DNA topoisomerase type II (ATP-hydrolyzing) activity//DNA binding, bending//DNA binding//ATP binding//phosphatidylinositol binding GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.36613 BF_2 1926.92 26.79 3296 546676952 ERL87876.1 1888 2.5e-208 hypothetical protein D910_05264 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 943 4.0e-100 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01700//PF03015//PF01370//PF01073 Orbivirus VP3 (T2) protein//Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0008209//GO:0055114//GO:0006694//GO:0008207 estrogen metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0005198//GO:0016616//GO:0003824//GO:0050662//GO:0003854//GO:0080019 structural molecule activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.36614 BF_2 409.49 4.18 4385 642937338 XP_008198794.1 897 2.8e-93 PREDICTED: innexin inx7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3W6 575 2.5e-57 Innexin inx7 OS=Drosophila melanogaster GN=Inx7 PE=2 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.36615 BF_2 694.70 2.40 12385 91092464 XP_970082.1 4337 0.0e+00 PREDICTED: glycine dehydrogenase (decarboxylating), mitochondrial [Tribolium castaneum]>gi|270004725|gb|EFA01173.1| hypothetical protein TcasGA2_TC010496 [Tribolium castaneum] 332372930 BT126644.1 662 0 Dendroctonus ponderosae clone DPO0411_K02 unknown mRNA K00281 GLDC, gcvP glycine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00281 P23378 3262 0.0e+00 Glycine dehydrogenase (decarboxylating), mitochondrial OS=Homo sapiens GN=GLDC PE=1 SV=2 PF01053//PF01212//PF02347//PF01176//PF00344 Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Glycine cleavage system P-protein//Translation initiation factor 1A / IF-1//SecY translocase GO:0015031//GO:0055114//GO:0006566//GO:0006563//GO:0006520//GO:0006546//GO:0006544//GO:0006413//GO:0006446 protein transport//oxidation-reduction process//threonine metabolic process//L-serine metabolic process//cellular amino acid metabolic process//glycine catabolic process//glycine metabolic process//translational initiation//regulation of translational initiation GO:0016829//GO:0003743//GO:0004375//GO:0030170//GO:0003723 lyase activity//translation initiation factor activity//glycine dehydrogenase (decarboxylating) activity//pyridoxal phosphate binding//RNA binding GO:0005840//GO:0016020 ribosome//membrane KOG2040 Glycine dehydrogenase (decarboxylating) Cluster-8309.36616 BF_2 308.10 0.85 15439 642914058 XP_008201527.1 14432 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3114 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00018//PF14604//PF00435//PF00307//PF11616 SH3 domain//Variant SH3 domain//Spectrin repeat//Calponin homology (CH) domain//WD repeat binding protein EZH2 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.36617 BF_2 136.00 1.94 3225 270016078 EFA12526.1 1420 4.6e-154 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT34 769 5.8e-80 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.36619 BF_2 17.72 0.44 1969 571516260 XP_006569195.1 224 1.4e-15 PREDICTED: histidine-rich glycoprotein-like [Apis mellifera] -- -- -- -- -- -- -- -- -- P04929 188 8.3e-13 Histidine-rich glycoprotein OS=Plasmodium lophurae PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36620 BF_2 634.60 44.26 887 91091864 XP_968949.1 505 1.6e-48 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial [Tribolium castaneum]>gi|270001295|gb|EEZ97742.1| NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8 [Tribolium castaneum] -- -- -- -- -- K03964 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03964 Q02372 211 8.1e-16 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial OS=Bos taurus GN=NDUFB8 PE=1 SV=1 PF04839//PF05821 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65)//NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) GO:0006744//GO:0006118//GO:0006814//GO:0015992//GO:0042254//GO:0006120//GO:0006412 ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//proton transport//ribosome biogenesis//mitochondrial electron transport, NADH to ubiquinone//translation GO:0003735//GO:0008137//GO:0003954 structural constituent of ribosome//NADH dehydrogenase (ubiquinone) activity//NADH dehydrogenase activity GO:0005840//GO:0005739 ribosome//mitochondrion -- -- Cluster-8309.36621 BF_2 2444.02 16.51 6478 478250068 ENN70574.1 6277 0.0e+00 hypothetical protein YQE_12749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TDM6 841 5.2e-88 Disks large homolog 5 OS=Homo sapiens GN=DLG5 PE=1 SV=4 PF00595//PF04111//PF06156//PF13180//PF15898 PDZ domain (Also known as DHR or GLGF)//Autophagy protein Apg6//Protein of unknown function (DUF972)//PDZ domain//cGMP-dependent protein kinase interacting domain GO:0006260//GO:0006914 DNA replication//autophagy GO:0019901//GO:0005515 protein kinase binding//protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.36622 BF_2 977.84 50.70 1094 91079744 XP_970506.1 444 2.3e-41 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 170043821 XM_001849518.1 105 2.07718e-45 Culex quinquefasciatus acyl-coa dehydrogenase, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 404 4.2e-38 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF00441 Acyl-CoA dehydrogenase, C-terminal domain GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.36623 BF_2 1607.36 18.18 3986 478254062 ENN74354.1 272 7.5e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36625 BF_2 664.96 11.27 2756 91085939 XP_970530.1 645 2.9e-64 PREDICTED: longitudinals lacking protein-like [Tribolium castaneum]>gi|270010169|gb|EFA06617.1| hypothetical protein TcasGA2_TC009535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 601 1.5e-60 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36627 BF_2 49.01 367.28 241 350646286 CCD59012.1 147 1.4e-07 saposin containing protein [Schistosoma mansoni] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36628 BF_2 10580.39 277.87 1880 531449435 AGT57858.1 1551 1.7e-169 cytochrome P450 6ef1, partial [Leptinotarsa decemlineata] 170072405 XM_001870137.1 44 2.93591e-11 Culex quinquefasciatus cytochrome P450 6a8, mRNA K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1047 2.0e-112 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.36629 BF_2 2824.03 27.60 4568 642912745 XP_967796.2 1980 7.6e-219 PREDICTED: protein toll [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08953 1239 2.6e-134 Protein toll OS=Drosophila melanogaster GN=Tl PE=1 SV=1 PF13855//PF01582//PF00560//PF13676 Leucine rich repeat//TIR domain//Leucine Rich Repeat//TIR domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.36630 BF_2 1028.36 4.88 9097 332375166 AEE62724.1 996 1.9e-104 unknown [Dendroctonus ponderosae]>gi|478252403|gb|ENN72829.1| hypothetical protein YQE_10632, partial [Dendroctonus ponderosae]>gi|546680735|gb|ERL90961.1| hypothetical protein D910_08303 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 736 1.1e-75 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF08506//PF10371//PF01118//PF01073//PF13855//PF03015//PF01370//PF03435//PF09107 Cse1//Domain of unknown function//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//Leucine rich repeat//Male sterility protein//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Elongation factor SelB, winged helix GO:0008210//GO:0006448//GO:0006886//GO:0006694//GO:0055114//GO:0008209//GO:0001514//GO:0008207 estrogen metabolic process//regulation of translational elongation//intracellular protein transport//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//selenocysteine incorporation//C21-steroid hormone metabolic process GO:0051287//GO:0016491//GO:0005515//GO:0003723//GO:0003824//GO:0005525//GO:0003746//GO:0016616//GO:0003854//GO:0050662//GO:0016620//GO:0016903//GO:0080019 NAD binding//oxidoreductase activity//protein binding//RNA binding//catalytic activity//GTP binding//translation elongation factor activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the aldehyde or oxo group of donors//fatty-acyl-CoA reductase (alcohol-forming) activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG1221 Acyl-CoA reductase Cluster-8309.36633 BF_2 10.76 0.39 1452 815805772 XP_012223637.1 252 5.7e-19 PREDICTED: 60S ribosomal protein L37 isoform X1 [Linepithema humile] 70909882 AM049128.1 86 1.01261e-34 Sphaerius sp. APV-2005 mRNA for ribosomal protein L37e (rpL37e gene) K02922 RP-L37e, RPL37 large subunit ribosomal protein L37e http://www.genome.jp/dbget-bin/www_bget?ko:K02922 Q962S7 247 8.9e-20 60S ribosomal protein L37 OS=Spodoptera frugiperda GN=RpL37 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG3475 60S ribosomal protein L37 Cluster-8309.36634 BF_2 8700.07 409.00 1177 755948956 XP_011300956.1 1243 5.6e-134 PREDICTED: 40S ribosomal protein S4 [Fopius arisanus] 264667394 GU120433.1 356 0 Chrysomela tremulae ribosomal protein S4 (RpS4) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q56FH2 1208 2.6e-131 40S ribosomal protein S4 OS=Lysiphlebus testaceipes GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.36635 BF_2 482.85 6.77 3271 642929336 XP_008195791.1 700 1.4e-70 PREDICTED: AMP deaminase 2 isoform X2 [Tribolium castaneum] 194769475 XM_001966794.1 153 1.31437e-71 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 449 7.5e-43 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00962//PF00465 Adenosine/AMP deaminase//Iron-containing alcohol dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0046872//GO:0019239 oxidoreductase activity//metal ion binding//deaminase activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.36636 BF_2 2699.00 58.99 2201 193591726 XP_001944018.1 666 8.5e-67 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 531454218 KF137655.1 53 3.42241e-16 Leptinotarsa decemlineata Kruppel-like protein 1 (Kr-h1) mRNA, complete cds -- -- -- -- Q6ZN57 621 5.8e-63 Zinc finger protein 2 homolog OS=Homo sapiens GN=ZFP2 PE=1 SV=1 PF00096//PF13465//PF13912//PF01192//PF04810 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//RNA polymerase Rpb6//Sec23/Sec24 zinc finger GO:0006351//GO:0006144//GO:0006886//GO:0006888//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//intracellular protein transport//ER to Golgi vesicle-mediated transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0030127//GO:0005730 COPII vesicle coat//nucleolus -- -- Cluster-8309.36637 BF_2 164006.32 1722.57 4270 91081471 XP_967871.1 2277 2.6e-253 PREDICTED: muscle LIM protein Mlp84B isoform X2 [Tribolium castaneum] 674656866 KJ872589.1 597 0 Monochamus alternatus muscle LIM protein mRNA, partial cds -- -- -- -- Q24400 1838 8.5e-204 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.36639 BF_2 21434.23 93.66 9860 642915260 XP_008190547.1 1523 1.6e-165 PREDICTED: titin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3664 BF_2 1.00 0.39 392 338714806 XP_003363153.1 202 9.6e-14 PREDICTED: nucleolin-like [Equus caballus] 164697055 AK314106.1 380 0 Homo sapiens cDNA, FLJ94794, highly similar to Homo sapiens prothymosin, alpha (gene sequence 28) (PTMA), mRNA K13784 PTMA prothymosin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13784 -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.36640 BF_2 2.00 0.63 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.36641 BF_2 112784.81 2767.44 1992 568253794 ETN62859.1 2234 1.2e-248 Elongation factor 1-alpha 2 [Anopheles darlingi] 727098916 KJ534557.1 786 0 Colaphellus bowringi elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P05303 2201 3.2e-246 Elongation factor 1-alpha 2 OS=Drosophila melanogaster GN=Ef1alpha100E PE=2 SV=2 PF03144//PF02615//PF01926 Elongation factor Tu domain 2//Malate/L-lactate dehydrogenase//50S ribosome-binding GTPase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0005525//GO:0016491 GTP binding//oxidoreductase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.36643 BF_2 199.41 3.73 2521 478250665 ENN71157.1 587 1.4e-57 hypothetical protein YQE_12088, partial [Dendroctonus ponderosae] 194884433 XM_001976222.1 195 4.53742e-95 Drosophila erecta GG22771 (Dere\GG22771), mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 545 4.3e-54 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0005524//GO:0003774 ATP binding//motor activity GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.36644 BF_2 24712.06 914.97 1417 357625515 EHJ75936.1 1289 3.1e-139 ribosomal protein P0 [Danaus plexippus] 39651866 AJ534439.1 387 0 Timarcha balearica mRNA for 60S acidic ribosomal protein P0 (rpP0 gene) K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 Q9U3U0 1227 2.0e-133 60S acidic ribosomal protein P0 OS=Ceratitis capitata GN=RpLP0 PE=3 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0815 60S acidic ribosomal protein P0 Cluster-8309.36646 BF_2 519.28 17.38 1537 575503657 AHG97630.1 1798 3.2e-198 cytochrome oxidase subunit I, partial (mitochondrion) [Batocera horsfieldi] 575503656 KF737820.1 1257 0 Batocera horsfieldi voucher HNAU.PP 041 cytochrome oxidase subunit I gene, partial cds; mitochondrial K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00400 1577 5.6e-174 Cytochrome c oxidase subunit 1 OS=Drosophila yakuba GN=mt:CoI PE=3 SV=2 -- -- -- -- -- -- -- -- KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.36647 BF_2 260.79 3.17 3730 58294539 AAW70172.1 1354 2.4e-146 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 508 0 Apriona germari transferrin mRNA, complete cds K06569 MFI2 melanoma-associated antigen p97 http://www.genome.jp/dbget-bin/www_bget?ko:K06569 Q02942 939 1.3e-99 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006879//GO:0006826 cellular iron ion homeostasis//iron ion transport GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.36648 BF_2 245.33 17.14 886 189236619 XP_001816527.1 890 3.6e-93 PREDICTED: N-alpha-acetyltransferase 20 [Tribolium castaneum]>gi|270005230|gb|EFA01678.1| hypothetical protein TcasGA2_TC007251 [Tribolium castaneum] 572306440 XM_006619049.1 224 1.17726e-111 PREDICTED: Apis dorsata N-alpha-acetyltransferase 20-like (LOC102677987), transcript variant X1, mRNA K17972 NAA20, NAT3 N-terminal acetyltransferase B complex catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17972 Q58ED9 716 2.2e-74 N-alpha-acetyltransferase 20 OS=Danio rerio GN=naa20 PE=2 SV=1 PF00583//PF13508//PF08445//PF13673 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3234 Acetyltransferase, (GNAT) family Cluster-8309.36651 BF_2 519355.70 13734.55 1869 642915179 XP_008190507.1 362 1.3e-31 PREDICTED: uncharacterized protein LOC659076 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36652 BF_2 213.07 0.83 10963 642920909 XP_008192611.1 9151 0.0e+00 PREDICTED: spectrin beta chain isoform X5 [Tribolium castaneum] 642920908 XM_008194389.1 1970 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7742 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00435//PF01857//PF00307 Spectrin repeat//Retinoblastoma-associated protein B domain//Calponin homology (CH) domain GO:0051726 regulation of cell cycle GO:0005515 protein binding GO:0005634 nucleus KOG0517 Beta-spectrin Cluster-8309.36653 BF_2 221.57 3.81 2720 91087441 XP_975685.1 230 3.8e-16 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27017 169 1.8e-10 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.36655 BF_2 6184.40 356.92 1012 373842654 AEY77316.1 564 2.6e-55 extracellular Cu/Zn-superoxide dismutase [Phaedon cochleariae] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 473 3.8e-46 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.36656 BF_2 26.12 1.24 1171 820805560 AKG92771.1 553 5.7e-54 daugherless [Leptinotarsa decemlineata] 805782450 XM_012284176.1 90 4.85138e-37 PREDICTED: Megachile rotundata protein daughterless (LOC100877694), transcript variant X15, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 382 1.6e-35 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.36657 BF_2 4540.74 42.40 4767 332375456 AEE62869.1 2175 1.9e-241 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 149 3.2165e-69 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 1823 5.2e-202 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF00224//PF00478//PF03328 Pyruvate kinase, barrel domain//IMP dehydrogenase / GMP reductase domain//HpcH/HpaI aldolase/citrate lyase family GO:0055114//GO:0006094//GO:0015976//GO:0006144//GO:0006096 oxidation-reduction process//gluconeogenesis//carbon utilization//purine nucleobase metabolic process//glycolytic process GO:0000287//GO:0004743//GO:0030955//GO:0003824 magnesium ion binding//pyruvate kinase activity//potassium ion binding//catalytic activity -- -- KOG2323 Pyruvate kinase Cluster-8309.36658 BF_2 18331.49 202.45 4075 478262392 ENN81063.1 5669 0.0e+00 hypothetical protein YQE_02432, partial [Dendroctonus ponderosae] 642911110 XM_008202361.1 1374 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 2089 6.4e-233 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF13895//PF00041//PF06293//PF00069//PF07714 Immunoglobulin domain//Fibronectin type III domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0005515//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein binding//protein kinase activity GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36659 BF_2 64.13 0.51 5548 642934860 XP_971174.2 3111 0.0e+00 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] 198472181 XM_001355830.2 178 2.83615e-85 Drosophila pseudoobscura pseudoobscura GA11069 (Dpse\GA11069), partial mRNA K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 2572 8.5e-289 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00175//PF00667//PF00258 Oxidoreductase NAD-binding domain//FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.36660 BF_2 879.30 25.32 1740 674304018 AIL23540.1 539 3.6e-52 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q93112 393 1.2e-36 Glutathione S-transferase 1, isoform C OS=Anopheles gambiae GN=GstD1 PE=1 SV=2 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36663 BF_2 2914.09 42.37 3164 270003289 EEZ99736.1 3087 0.0e+00 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.04705e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00168//PF00130 C2 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.36664 BF_2 1175.71 28.87 1991 91094383 XP_971062.1 805 5.8e-83 PREDICTED: alanyl-tRNA editing protein Aarsd1 [Tribolium castaneum]>gi|270014911|gb|EFA11359.1| hypothetical protein TcasGA2_TC011516 [Tribolium castaneum] 332375886 BT128123.1 63 8.53243e-22 Dendroctonus ponderosae clone DPO1131_O04 unknown mRNA K07050 AARSD1, ALAX misacylated tRNA(Ala) deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K07050 Q32LK1 604 4.9e-61 Alanyl-tRNA editing protein Aarsd1 OS=Bos taurus GN=AARSD1 PE=2 SV=1 PF01411//PF01200//PF03367//PF07973//PF01176 tRNA synthetases class II (A)//Ribosomal protein S28e//ZPR1 zinc-finger domain//Threonyl and Alanyl tRNA synthetase second additional domain//Translation initiation factor 1A / IF-1 GO:0042254//GO:0043039//GO:0006522//GO:0006413//GO:0006446//GO:0006412//GO:0006531//GO:0006419 ribosome biogenesis//tRNA aminoacylation//alanine metabolic process//translational initiation//regulation of translational initiation//translation//aspartate metabolic process//alanyl-tRNA aminoacylation GO:0016876//GO:0000166//GO:0008270//GO:0003735//GO:0003743//GO:0005524//GO:0003676//GO:0004813//GO:0003723 ligase activity, forming aminoacyl-tRNA and related compounds//nucleotide binding//zinc ion binding//structural constituent of ribosome//translation initiation factor activity//ATP binding//nucleic acid binding//alanine-tRNA ligase activity//RNA binding GO:0005737//GO:0005622//GO:0005840 cytoplasm//intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-8309.36665 BF_2 23287.87 316.41 3366 613485521 AHX26755.1 646 2.7e-64 ATF4 [Tribolium castaneum] -- -- -- -- -- K04374 ATF4, CREB2 cyclic AMP-dependent transcription factor ATF-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04374 Q9GPH3 194 2.9e-13 Activating transcription factor of chaperone OS=Bombyx mori GN=ATFC PE=2 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.36666 BF_2 58.00 4.75 798 642912066 XP_008200783.1 616 1.9e-61 PREDICTED: cytochrome P450 monooxygenase isoform X1 [Tribolium castaneum]>gi|270002891|gb|EEZ99338.1| cytochrome P450 6BQ13 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 518 1.8e-51 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0016705 oxidoreductase activity//iron ion binding//metal ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.36667 BF_2 1699.78 20.29 3792 91093819 XP_968936.1 2345 3.0e-261 PREDICTED: glutamate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270015904|gb|EFA12352.1| hypothetical protein TcasGA2_TC002057 [Tribolium castaneum] 195573296 XM_002104594.1 246 3.056e-123 Drosophila simulans GD18335 (Dsim\GD18335), mRNA K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 2045 7.5e-228 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF02826//PF00208//PF02812 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain GO:0055114//GO:0006520//GO:0006118 oxidation-reduction process//cellular amino acid metabolic process//obsolete electron transport GO:0051287//GO:0016639//GO:0016491//GO:0000166 NAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor//oxidoreductase activity//nucleotide binding -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.36669 BF_2 258.29 4.81 2535 642913601 XP_008201081.1 459 9.8e-43 PREDICTED: pollen-specific leucine-rich repeat extensin-like protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36670 BF_2 15147.98 331.10 2201 642913603 XP_008201082.1 304 8.0e-25 PREDICTED: extensin-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36671 BF_2 354.37 3.78 4205 642913457 XP_008201020.1 4046 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.2e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00784//PF00023 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.36672 BF_2 499.62 9.62 2460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01529//PF00918 DHHC palmitoyltransferase//Gastrin/cholecystokinin family GO:0007165 signal transduction GO:0008270//GO:0005179 zinc ion binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.36673 BF_2 5.28 0.54 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36674 BF_2 19.09 0.43 2139 642939251 XP_008194779.1 688 2.3e-69 PREDICTED: UPF0602 protein C4orf47-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7E2U8 309 8.4e-27 UPF0602 protein C4orf47 OS=Homo sapiens GN=C4orf47 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36675 BF_2 453.48 1.87 10412 91090496 XP_969212.1 1701 3.9e-186 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] 642935356 XM_964189.2 200 3.14441e-97 PREDICTED: Tribolium castaneum forkhead box protein P4 (LOC657747), mRNA K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 1044 2.4e-111 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF01299//PF00250//PF01546//PF04277 Lysosome-associated membrane glycoprotein (Lamp)//Forkhead domain//Peptidase family M20/M25/M40//Oxaloacetate decarboxylase, gamma chain GO:0006560//GO:0008152//GO:0006520//GO:0006508//GO:0000051//GO:0006525//GO:0006814//GO:0006355//GO:0006090//GO:0071436 proline metabolic process//metabolic process//cellular amino acid metabolic process//proteolysis//obsolete urea cycle intermediate metabolic process//arginine metabolic process//sodium ion transport//regulation of transcription, DNA-templated//pyruvate metabolic process//sodium ion export GO:0004046//GO:0015081//GO:0008237//GO:0008948//GO:0016787//GO:0003700//GO:0043565 aminoacylase activity//sodium ion transmembrane transporter activity//metallopeptidase activity//oxaloacetate decarboxylase activity//hydrolase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016020//GO:0005737 transcription factor complex//membrane//cytoplasm KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.36676 BF_2 620.55 3.43 7863 642937519 XP_008199079.1 802 5.1e-82 PREDICTED: heterogeneous nuclear ribonucleoprotein 27C isoform X3 [Tribolium castaneum] 642937522 XM_008200859.1 133 4.17047e-60 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X5, mRNA K14411 MSI RNA-binding protein Musashi http://www.genome.jp/dbget-bin/www_bget?ko:K14411 P48809 573 7.6e-57 Heterogeneous nuclear ribonucleoprotein 27C OS=Drosophila melanogaster GN=Hrb27C PE=1 SV=2 PF00076//PF08085 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Entericidin EcnA/B family GO:0009636 response to toxic substance GO:0003676 nucleic acid binding GO:0016020 membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.36678 BF_2 782.34 23.02 1709 91079995 XP_970906.1 932 9.4e-98 PREDICTED: FK506-binding protein 2 isoform X2 [Tribolium castaneum]>gi|270003237|gb|EEZ99684.1| hypothetical protein TcasGA2_TC002441 [Tribolium castaneum] -- -- -- -- -- K09577 FKBP14 FK506-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09577 Q9NWM8 413 5.9e-39 Peptidyl-prolyl cis-trans isomerase FKBP14 OS=Homo sapiens GN=FKBP14 PE=1 SV=1 PF13405//PF10591//PF13833//PF00036//PF13499//PF00254//PF13202 EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain pair//FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand GO:0006457//GO:0007165 protein folding//signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.36679 BF_2 871.59 26.10 1684 91079995 XP_970906.1 932 9.3e-98 PREDICTED: FK506-binding protein 2 isoform X2 [Tribolium castaneum]>gi|270003237|gb|EEZ99684.1| hypothetical protein TcasGA2_TC002441 [Tribolium castaneum] -- -- -- -- -- K09577 FKBP14 FK506-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09577 Q9NWM8 413 5.8e-39 Peptidyl-prolyl cis-trans isomerase FKBP14 OS=Homo sapiens GN=FKBP14 PE=1 SV=1 PF13499//PF13833//PF10591//PF13405//PF00036//PF00254//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand GO:0007165//GO:0006457 signal transduction//protein folding GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.36680 BF_2 43.15 0.71 2833 91081545 XP_974976.1 1293 2.2e-139 PREDICTED: calumenin [Tribolium castaneum]>gi|270006175|gb|EFA02623.1| hypothetical protein TcasGA2_TC008343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDD8 880 6.9e-93 Calumenin OS=Pongo abelii GN=CALU PE=2 SV=1 PF13202//PF13499//PF10591//PF08707//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//Primase C terminal 2 (PriCT-2)//EF-hand domain pair//EF hand//EF-hand domain GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.36681 BF_2 1056.47 11.09 4274 642928729 XP_008199757.1 2652 8.4e-297 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 746860384 XM_011062730.1 215 5.89378e-106 PREDICTED: Acromyrmex echinatior phosphoenolpyruvate carboxykinase [GTP]-like (LOC105149957), transcript variant X4, mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 2332 4.4e-261 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.36683 BF_2 1483.07 42.91 1733 91082507 XP_973065.1 1686 3.5e-185 PREDICTED: protein kinase DC2 [Tribolium castaneum]>gi|270007546|gb|EFA03994.1| hypothetical protein TcasGA2_TC014143 [Tribolium castaneum] 645007450 XM_008218052.1 132 3.25651e-60 PREDICTED: Nasonia vitripennis protein kinase DC2 (LOC100119822), transcript variant X4, mRNA K19584 PRKX protein kinase X http://www.genome.jp/dbget-bin/www_bget?ko:K19584 P16912 1332 1.6e-145 Protein kinase DC2 OS=Drosophila melanogaster GN=Pka-C3 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.36685 BF_2 76.51 1.53 2384 91086399 XP_974859.1 2065 5.5e-229 PREDICTED: 26S protease regulatory subunit 4 [Tribolium castaneum]>gi|270010293|gb|EFA06741.1| hypothetical protein TcasGA2_TC009675 [Tribolium castaneum] 829812394 XM_012773957.1 384 0 PREDICTED: Microcebus murinus proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1), mRNA K03062 PSMC1, RPT2 26S proteasome regulatory subunit T2 http://www.genome.jp/dbget-bin/www_bget?ko:K03062 P48601 1995 3.0e-222 26S protease regulatory subunit 4 OS=Drosophila melanogaster GN=Rpt2 PE=1 SV=2 PF00910//PF00931//PF00005//PF07726//PF02562//PF02367//PF00004//PF07724//PF01695//PF07728//PF01057//PF05496//PF00158//PF06068 RNA helicase//NB-ARC domain//ABC transporter//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus GO:0002949//GO:0006310//GO:0030163//GO:0006355//GO:0019079//GO:0006281 tRNA threonylcarbamoyladenosine modification//DNA recombination//protein catabolic process//regulation of transcription, DNA-templated//viral genome replication//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0043531//GO:0016887//GO:0005524//GO:0008134 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//ADP binding//ATPase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0005737//GO:0009379 replication fork//transcription factor complex//cytoplasm//Holliday junction helicase complex KOG0726 26S proteasome regulatory complex, ATPase RPT2 Cluster-8309.36686 BF_2 75.34 3.46 1199 332376935 AEE63607.1 581 3.3e-57 unknown [Dendroctonus ponderosae]>gi|478259710|gb|ENN79554.1| hypothetical protein YQE_04016, partial [Dendroctonus ponderosae]>gi|546676265|gb|ERL87311.1| hypothetical protein D910_04706 [Dendroctonus ponderosae] 758206659 XM_011327360.1 36 5.1865e-07 Fusarium graminearum PH-1 aspartate aminotransferase partial mRNA K14454 GOT1 aspartate aminotransferase, cytoplasmic http://www.genome.jp/dbget-bin/www_bget?ko:K14454 P13221 469 1.3e-45 Aspartate aminotransferase, cytoplasmic OS=Rattus norvegicus GN=Got1 PE=1 SV=3 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.36687 BF_2 4462.36 63.50 3227 91078686 XP_971015.1 882 1.1e-91 PREDICTED: gamma-glutamyl hydrolase isoform X1 [Tribolium castaneum]>gi|642915849|ref|XP_008196208.1| PREDICTED: gamma-glutamyl hydrolase isoform X1 [Tribolium castaneum]>gi|270003762|gb|EFA00210.1| hypothetical protein TcasGA2_TC003035 [Tribolium castaneum] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 520 4.3e-51 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722 Peptidase C26 GO:0006541 glutamine metabolic process GO:0016787 hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.36689 BF_2 46.11 0.73 2930 270002097 EEZ98544.1 638 2.0e-63 hypothetical protein TcasGA2_TC001048 [Tribolium castaneum] 642913817 XM_008202950.1 224 3.99631e-111 PREDICTED: Tribolium castaneum myosin light chain alkali (LOC662923), transcript variant X1, mRNA K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 450 5.2e-43 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF12558//PF13405 EF-hand domain pair//ATP-binding cassette cobalt transporter//EF-hand domain -- -- GO:0005509//GO:0016820 calcium ion binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.3669 BF_2 3.76 0.50 604 270003851 EFA00299.1 300 6.4e-25 hypothetical protein TcasGA2_TC003132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36692 BF_2 380.00 39.85 686 91077530 XP_970573.1 159 1.6e-08 PREDICTED: tyrosine-protein phosphatase non-receptor type 23 [Tribolium castaneum]>gi|270001592|gb|EEZ98039.1| hypothetical protein TcasGA2_TC000442 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36694 BF_2 275.31 1.86 6477 642919008 XP_008191694.1 4125 0.0e+00 PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum]>gi|642919010|ref|XP_008191695.1| PREDICTED: adenylate cyclase type 9 isoform X1 [Tribolium castaneum] 742179525 XM_010889443.1 55 7.86127e-17 PREDICTED: Esox lucius adenylate cyclase 9 (adcy9), transcript variant X2, mRNA K08049 ADCY9 adenylate cyclase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08049 P51830 1008 2.3e-107 Adenylate cyclase type 9 OS=Mus musculus GN=Adcy9 PE=1 SV=1 PF00211//PF07701//PF06327 Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated//Domain of Unknown Function (DUF1053) GO:0009190//GO:0035556//GO:0006171//GO:0006144//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//cAMP biosynthetic process//purine nucleobase metabolic process//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0004016//GO:0004383 phosphorus-oxygen lyase activity//adenylate cyclase activity//guanylate cyclase activity GO:0005886 plasma membrane KOG3618 Adenylyl cyclase Cluster-8309.36696 BF_2 902.68 15.32 2752 91089191 XP_974448.1 2190 2.0e-243 PREDICTED: signal recognition particle subunit SRP68 [Tribolium castaneum]>gi|270012460|gb|EFA08908.1| hypothetical protein TcasGA2_TC006613 [Tribolium castaneum] -- -- -- -- -- K03107 SRP68 signal recognition particle subunit SRP68 http://www.genome.jp/dbget-bin/www_bget?ko:K03107 Q9VSS2 1309 1.2e-142 Signal recognition particle subunit SRP68 OS=Drosophila melanogaster GN=Srp68 PE=2 SV=1 PF16969//PF13176 RNA-binding signal recognition particle 68//Tetratricopeptide repeat GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312//GO:0030942//GO:0005047//GO:0005515 7S RNA binding//endoplasmic reticulum signal peptide binding//signal recognition particle binding//protein binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG2460 Signal recognition particle, subunit Srp68 Cluster-8309.36697 BF_2 41.60 1.22 1717 642915041 XP_008190385.1 548 3.2e-53 PREDICTED: gamma-interferon-inducible lysosomal thiol reductase-like [Tribolium castaneum] -- -- -- -- -- K08059 IFI30, GILT interferon, gamma-inducible protein 30 http://www.genome.jp/dbget-bin/www_bget?ko:K08059 A6QPN6 281 1.2e-23 Gamma-interferon-inducible lysosomal thiol reductase OS=Bos taurus GN=IFI30 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3160 Gamma-interferon inducible lysosomal thiol reductase Cluster-8309.36698 BF_2 80.00 3.27 1310 91079754 XP_970847.1 290 2.0e-23 PREDICTED: peptidoglycan-recognition protein LF [Tribolium castaneum]>gi|270004814|gb|EFA01262.1| hypothetical protein TcasGA2_TC002546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75594 209 2.0e-15 Peptidoglycan recognition protein 1 OS=Homo sapiens GN=PGLYRP1 PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0006807//GO:0009253 peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.36699 BF_2 706.00 22.31 1611 332375546 AEE62914.1 865 5.2e-90 unknown [Dendroctonus ponderosae]>gi|478250118|gb|ENN70624.1| hypothetical protein YQE_12798, partial [Dendroctonus ponderosae]>gi|546674473|gb|ERL85838.1| hypothetical protein D910_03253 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0H3 526 4.4e-52 Lipid droplet-associated hydrolase OS=Drosophila melanogaster GN=CG9186 PE=2 SV=1 PF06821//PF02450 Serine hydrolase//Lecithin:cholesterol acyltransferase GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0016787//GO:0008374 hydrolase activity//O-acyltransferase activity -- -- KOG3975 Uncharacterized conserved protein Cluster-8309.36701 BF_2 276.91 96.62 406 529172383 BAN67667.1 141 1.2e-06 riptocin [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q27905 141 4.8e-08 Probable antibacterial peptide polyprotein OS=Riptortus clavatus PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36704 BF_2 4176.00 58.80 3258 642933304 XP_008197362.1 2123 1.4e-235 PREDICTED: eukaryotic peptide chain release factor GTP-binding subunit ERF3A isoform X1 [Tribolium castaneum] -- -- -- -- -- K03267 ERF3, GSPT peptide chain release factor subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03267 P15170 1687 2.1e-186 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A OS=Homo sapiens GN=GSPT1 PE=1 SV=1 PF00503//PF03144//PF01926 G-protein alpha subunit//Elongation factor Tu domain 2//50S ribosome-binding GTPase GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0004871//GO:0019001//GO:0031683//GO:0005525 GTPase activity//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTP binding -- -- KOG0459 Polypeptide release factor 3 Cluster-8309.36705 BF_2 9156.93 549.71 984 646703952 KDR12362.1 665 4.9e-67 Superoxide dismutase [Cu-Zn] [Zootermopsis nevadensis] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P41973 606 1.4e-61 Superoxide dismutase [Cu-Zn] OS=Drosophila willistoni GN=Sod PE=3 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.36707 BF_2 1310.99 36.04 1809 91090714 XP_975034.1 589 5.9e-58 PREDICTED: 27 kDa hemolymph protein [Tribolium castaneum]>gi|270013294|gb|EFA09742.1| hypothetical protein TcasGA2_TC011877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q25513 285 4.3e-24 27 kDa hemolymph glycoprotein OS=Manduca sexta PE=1 SV=1 PF03688 Nepovirus coat protein, C-terminal domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.36708 BF_2 168.56 3.65 2219 642930886 XP_008196126.1 427 4.4e-39 PREDICTED: myb-like protein X isoform X6 [Tribolium castaneum] 642930891 XM_008197907.1 97 1.19801e-40 PREDICTED: Tribolium castaneum protein-methionine sulfoxide oxidase MICAL3 (LOC658955), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36709 BF_2 242.00 277.77 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36710 BF_2 75.80 2.19 1738 478252870 ENN73259.1 802 1.1e-82 hypothetical protein YQE_10155, partial [Dendroctonus ponderosae]>gi|546674747|gb|ERL86052.1| hypothetical protein D910_03466 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U145 311 4.0e-27 Transmembrane protein 64 OS=Mus musculus GN=Tmem64 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36711 BF_2 2896708.00 121560.72 1284 133916482 CAM36311.1 154 1.2e-07 hypothetical protein [Thermobia domestica] 359294281 JN986793.1 1072 0 Batocera lineolata mitochondrion, complete genome -- -- -- -- -- -- -- -- PF02459 Adenoviral DNA terminal protein GO:0006260 DNA replication GO:0003677 DNA binding -- -- -- -- Cluster-8309.36716 BF_2 61.02 0.47 5695 478257768 ENN77911.1 659 1.4e-65 hypothetical protein YQE_05588, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI18 312 1.0e-26 Protein yellow OS=Drosophila pseudoobscura pseudoobscura GN=y PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36717 BF_2 608.24 8.75 3196 751457144 XP_011183174.1 1662 4.0e-182 PREDICTED: protein will die slowly [Bactrocera cucurbitae] 585715269 XM_006825240.1 164 9.85517e-78 PREDICTED: Saccoglossus kowalevskii protein will die slowly-like (LOC100375790), mRNA K14963 WDR5, SWD3, CPS30 COMPASS component SWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K14963 Q9V3J8 1615 4.6e-178 Protein will die slowly OS=Drosophila melanogaster GN=wds PE=1 SV=1 PF07569//PF02944//PF00400 TUP1-like enhancer of split//BESS motif//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus KOG0266 WD40 repeat-containing protein Cluster-8309.36718 BF_2 4465.14 56.03 3621 167444216 ABZ80669.1 216 2.1e-14 luxuriosin-like protein [Sitophilus zeamais] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.36720 BF_2 801.60 15.43 2461 242015216 XP_002428268.1 1387 2.4e-150 cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis]>gi|212512842|gb|EEB15530.1| cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis] 558203653 XM_006132037.1 59 1.77085e-19 PREDICTED: Pelodiscus sinensis mitogen-activated protein kinase kinase 7 (MAP2K7), partial mRNA K04432 MAP2K3, MKK3 mitogen-activated protein kinase kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04432 O09110 1122 5.2e-121 Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus GN=Map2k3 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.36721 BF_2 15.40 0.76 1131 332376312 AEE63296.1 390 4.4e-35 unknown [Dendroctonus ponderosae] 332376311 BT128338.1 35 1.75858e-06 Dendroctonus ponderosae clone DPO1410_H07 unknown mRNA -- -- -- -- P02511 131 1.9e-06 Alpha-crystallin B chain OS=Homo sapiens GN=CRYAB PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3591 Alpha crystallins Cluster-8309.36723 BF_2 993.24 18.73 2506 637366323 XP_008121191.1 644 3.4e-64 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Anolis carolinensis] 195570403 XM_002103161.1 88 1.36506e-35 Drosophila simulans GD19093 (Dsim\GD19093), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 590 2.6e-59 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF13912//PF11615//PF07776//PF16622//PF00096//PF13465 C2H2-type zinc finger//Protein of unknown function (DUF3249)//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain GO:0000266 mitochondrial fission GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005739//GO:0005634 mitochondrion//nucleus -- -- Cluster-8309.36724 BF_2 815.35 7.57 4793 270008506 EFA04954.1 2027 2.8e-224 hypothetical protein TcasGA2_TC015023 [Tribolium castaneum] 817187826 XM_012433045.1 176 3.16626e-84 PREDICTED: Orussus abietinus cytospin-A (LOC105704102), transcript variant X5, mRNA -- -- -- -- Q69YQ0 545 8.2e-54 Cytospin-A OS=Homo sapiens GN=SPECC1L PE=1 SV=2 PF09730//PF13851//PF00307//PF00769//PF03920 Microtubule-associated protein Bicaudal-D//Growth-arrest specific micro-tubule binding//Calponin homology (CH) domain//Ezrin/radixin/moesin family//Groucho/TLE N-terminal Q-rich domain GO:0006810//GO:0048870 transport//cell motility GO:0008092//GO:0005515 cytoskeletal protein binding//protein binding GO:0005737//GO:0031514//GO:0019898//GO:0005794 cytoplasm//motile cilium//extrinsic component of membrane//Golgi apparatus KOG4678 FOG: Calponin homology domain Cluster-8309.36726 BF_2 1367.94 2.13 27123 642915997 XP_008190849.1 3507 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02224 247 1.7e-18 Centromere-associated protein E OS=Homo sapiens GN=CENPE PE=1 SV=2 PF06280//PF02444//PF05280 Fn3-like domain//Hepatitis E virus ORF-2 (Putative capsid protein)//Flagellar transcriptional activator (FlhC) GO:1902208//GO:0045893 regulation of bacterial-type flagellum assembly//positive regulation of transcription, DNA-templated GO:0004252//GO:0003677 serine-type endopeptidase activity//DNA binding GO:0030430//GO:0005618//GO:0016020 host cell cytoplasm//cell wall//membrane -- -- Cluster-8309.36728 BF_2 5272.11 62.98 3789 478257467 ENN77623.1 2412 5.1e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 759061923 XM_011342000.1 74 1.25626e-27 PREDICTED: Cerapachys biroi phosphoglucomutase (LOC105281053), transcript variant X2, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 1.7e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF02880//PF00408//PF02879//PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0071704//GO:0005975 organic substance metabolic process//carbohydrate metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG0625 Phosphoglucomutase Cluster-8309.36729 BF_2 99.44 0.93 4770 642924642 XP_008194376.1 4300 0.0e+00 PREDICTED: tensin isoform X2 [Tribolium castaneum] 642924641 XM_008196154.1 177 8.76083e-85 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X2, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 768 1.1e-79 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.36730 BF_2 1730.36 8.50 8799 91084843 XP_966905.1 1396 7.6e-151 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] 827549413 XM_004927289.2 82 1.04711e-31 PREDICTED: Bombyx mori Kv channel-interacting protein 1 (LOC101740782), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 844 3.2e-88 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF00404//PF01370//PF13499//PF13833//PF10591//PF13405//PF13202//PF01118//PF01073//PF00036 Male sterility protein//Dockerin type I repeat//NAD dependent epimerase/dehydratase family//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//EF hand GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0005975//GO:0007165 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//carbohydrate metabolic process//signal transduction GO:0005509//GO:0003824//GO:0051287//GO:0080019//GO:0016620//GO:0003854//GO:0050662//GO:0004553//GO:0016616 calcium ion binding//catalytic activity//NAD binding//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//hydrolase activity, hydrolyzing O-glycosyl compounds//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.36731 BF_2 952.00 29.75 1626 91091362 XP_972603.1 648 7.6e-65 PREDICTED: uncharacterized protein LOC661347 [Tribolium castaneum]>gi|270014346|gb|EFA10794.1| hypothetical protein TcasGA2_TC012859 [Tribolium castaneum] -- -- -- -- -- K03962 NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03962 -- -- -- -- PF06479 Ribonuclease 2-5A GO:0051252//GO:0006397 regulation of RNA metabolic process//mRNA processing GO:0004540 ribonuclease activity -- -- -- -- Cluster-8309.36732 BF_2 1615.56 25.22 2967 642932670 XP_008196939.1 401 6.1e-36 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 2.6e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF09198//PF02179 Bacteriophage T4 beta-glucosyltransferase//BAG domain GO:0006304 DNA modification GO:0033821//GO:0051087 DNA beta-glucosyltransferase activity//chaperone binding -- -- KOG4361 BCL2-associated athanogene-like proteins and related BAG family chaperone regulators Cluster-8309.36734 BF_2 66.59 0.34 8381 557211143 CDJ50285.1 179 9.5e-10 hypothetical protein EBH_0032330 [Eimeria brunetti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00977 Histidine biosynthesis protein GO:0000105 histidine biosynthetic process -- -- -- -- -- -- Cluster-8309.36736 BF_2 115.93 0.66 7582 642920861 XP_008192589.1 3615 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 586 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3121 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF16656//PF07353//PF02480//PF07354//PF00041//PF13895 Tissue factor//Purple acid Phosphatase, N-terminal domain//Uroplakin II//Alphaherpesvirus glycoprotein E//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0061024//GO:0019497//GO:0007339 riboflavin metabolic process//membrane organization//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020//GO:0005576//GO:0030176 membrane//extracellular region//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.36737 BF_2 99.90 1.30 3510 642915176 XP_008190506.1 292 3.2e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36739 BF_2 356.00 5.19 3159 642934001 XP_973480.2 2866 0.0e+00 PREDICTED: wolframin isoform X1 [Tribolium castaneum] -- -- -- -- -- K14020 WFS1 wolfamin http://www.genome.jp/dbget-bin/www_bget?ko:K14020 P56695 526 8.6e-52 Wolframin OS=Mus musculus GN=Wfs1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3674 BF_2 2.00 0.42 484 332375102 AEE62692.1 191 2.2e-12 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36740 BF_2 116.57 4.71 1323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36741 BF_2 22140.66 72.55 13053 642920090 XP_008192200.1 2152 2.5e-238 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920089 XM_008193978.1 390 0 PREDICTED: Tribolium castaneum histone acetyltransferase Tip60 (LOC664310), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q5RBG4 1541 7.1e-169 Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 PF03719//PF13855//PF00560//PF01853//PF00333//PF05261//PF13508//PF00583 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//Leucine Rich Repeat//MOZ/SAS family//Ribosomal protein S5, N-terminal domain//TraM protein, DNA-binding//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0006355//GO:0042254//GO:0000746//GO:0042967//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//conjugation//acyl-carrier-protein biosynthetic process//translation GO:0003735//GO:0016747//GO:0003723//GO:0003677//GO:0008080//GO:0005515 structural constituent of ribosome//transferase activity, transferring acyl groups other than amino-acyl groups//RNA binding//DNA binding//N-acetyltransferase activity//protein binding GO:0005840//GO:0005634 ribosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.36742 BF_2 5176.41 239.85 1190 91088745 XP_975314.1 418 2.6e-38 PREDICTED: uncharacterized protein LOC664209 [Tribolium castaneum]>gi|270012304|gb|EFA08752.1| hypothetical protein TcasGA2_TC006429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284//PF00335 Membrane-associating domain//Tetraspanin family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.36743 BF_2 94.36 1.31 3310 307173098 EFN64217.1 811 2.0e-83 THAP domain-containing protein 9, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9H5L6 428 2.1e-40 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF04977//PF05485//PF00619//PF13851 Septum formation initiator//THAP domain//Caspase recruitment domain//Growth-arrest specific micro-tubule binding GO:0007049//GO:0042981//GO:0048870 cell cycle//regulation of apoptotic process//cell motility GO:0003676 nucleic acid binding GO:0031514 motile cilium -- -- Cluster-8309.36744 BF_2 39.23 0.34 5046 642925269 XP_008194486.1 1379 4.1e-149 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 790 3.3e-82 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF03600//PF01542//PF00939 Citrate transporter//Hepatitis C virus core protein//Sodium:sulfate symporter transmembrane region GO:0006810//GO:0006814//GO:0055085 transport//sodium ion transport//transmembrane transport GO:0005215//GO:0005198 transporter activity//structural molecule activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.36745 BF_2 413.72 2.88 6295 546683632 ERL93420.1 2078 4.5e-230 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 Q9PTP2 475 1.4e-45 Axin-related protein OS=Xenopus laevis PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36746 BF_2 176.00 0.89 8579 642921903 XP_008192938.1 883 2.3e-91 PREDICTED: uncharacterized protein LOC103312895 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF02892//PF08587//PF13465//PF00096 C2H2-type zinc finger//BED zinc finger//Ubiquitin associated domain (UBA)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0003677//GO:0004674//GO:0046872 DNA binding//protein serine/threonine kinase activity//metal ion binding -- -- -- -- Cluster-8309.36749 BF_2 1511.74 19.54 3524 270011248 EFA07696.1 495 9.1e-47 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53814 298 2.6e-25 Smoothelin OS=Homo sapiens GN=SMTN PE=1 SV=7 -- -- -- -- -- -- -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.36751 BF_2 1873.55 54.66 1721 642912485 XP_008200884.1 2209 7.9e-246 PREDICTED: protein hu-li tai shao isoform X2 [Tribolium castaneum] 752873776 XM_011255881.1 75 1.56963e-28 PREDICTED: Camponotus floridanus protein hu-li tai shao (LOC105250025), transcript variant X7, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1509 4.8e-166 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36753 BF_2 2198.95 8.14 11587 270002882 EEZ99329.1 2111 1.2e-233 hu li tai shao [Tribolium castaneum] 642912486 XM_008202663.1 133 6.15499e-60 PREDICTED: Tribolium castaneum protein hu-li tai shao (LOC659560), transcript variant X3, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1443 1.5e-157 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36754 BF_2 3828.89 8.78 18534 612342210 AHW99830.1 23501 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 2506 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 19805 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00520//PF00487//PF06423//PF06459//PF00622//PF01365//PF13499//PF13833//PF02815 Ion transport protein//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//SPRY domain//RIH domain//EF-hand domain pair//EF-hand domain pair//MIR domain GO:0006874//GO:0006816//GO:0055085//GO:0070588//GO:0006506//GO:0006811//GO:0006629 cellular calcium ion homeostasis//calcium ion transport//transmembrane transport//calcium ion transmembrane transport//GPI anchor biosynthetic process//ion transport//lipid metabolic process GO:0005216//GO:0005509//GO:0005262//GO:0005219//GO:0005515//GO:0016746 ion channel activity//calcium ion binding//calcium channel activity//ryanodine-sensitive calcium-release channel activity//protein binding//transferase activity, transferring acyl groups GO:0005622//GO:0016021//GO:0016020//GO:0005789 intracellular//integral component of membrane//membrane//endoplasmic reticulum membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.36756 BF_2 940.85 5.56 7360 642930787 XP_008196091.1 3584 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.7e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF07531//PF01428//PF00383//PF02217//PF16711//PF08211//PF08069 NHR1 homology to TAF//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region//Origin of replication binding protein//Actin-binding domain of plant-specific actin-binding protein//Cytidine and deoxycytidylate deaminase zinc-binding region//Ribosomal S13/S15 N-terminal domain GO:0006412//GO:0006206//GO:0006807//GO:0009972//GO:0006355//GO:0006260//GO:0042254//GO:0046087 translation//pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//cytidine deamination//regulation of transcription, DNA-templated//DNA replication//ribosome biogenesis//cytidine metabolic process GO:0004126//GO:0003688//GO:0003779//GO:0003735//GO:0008270//GO:0003700 cytidine deaminase activity//DNA replication origin binding//actin binding//structural constituent of ribosome//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0046809//GO:0005840 transcription factor complex//replication compartment//ribosome KOG3183 Predicted Zn-finger protein Cluster-8309.36757 BF_2 11014.69 44.30 10689 642935263 XP_008197938.1 6822 0.0e+00 PREDICTED: hemocytin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98092 5375 0.0e+00 Hemocytin OS=Bombyx mori PE=2 SV=1 PF05375//PF00093//PF11051//PF05805 Pacifastin inhibitor (LCMII)//von Willebrand factor type C domain//Mannosyltransferase putative//L6 membrane protein GO:0006486 protein glycosylation GO:0016757//GO:0030414//GO:0005515 transferase activity, transferring glycosyl groups//peptidase inhibitor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.36758 BF_2 13.99 0.37 1877 546681329 ERL91443.1 1252 8.1e-135 hypothetical protein D910_08773 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 197 7.2e-14 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36759 BF_2 6098.92 49.19 5474 642918013 XP_008198979.1 1042 5.3e-110 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 755 4.2e-78 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF02167//PF13442//PF00034 Cytochrome C1 family//Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome c GO:0006118 obsolete electron transport GO:0005488//GO:0009055//GO:0020037 binding//electron carrier activity//heme binding -- -- KOG3052 Cytochrome c1 Cluster-8309.36760 BF_2 157.72 1.25 5573 478262859 ENN81341.1 1820 3.3e-200 hypothetical protein YQE_02252, partial [Dendroctonus ponderosae] 213513283 NM_001141934.1 389 0 Tribolium castaneum estrogen-related receptor (Err), mRNA K08703 NR3BN, ERR estrogen-related receptor ERR http://www.genome.jp/dbget-bin/www_bget?ko:K08703 O95718 803 1.1e-83 Steroid hormone receptor ERR2 OS=Homo sapiens GN=ESRRB PE=1 SV=2 PF00104//PF00106//PF00324//PF00105//PF01370 Ligand-binding domain of nuclear hormone receptor//short chain dehydrogenase//Amino acid permease//Zinc finger, C4 type (two domains)//NAD dependent epimerase/dehydratase family GO:0006355//GO:0043401//GO:0008152//GO:0055085//GO:0006810 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//metabolic process//transmembrane transport//transport GO:0008270//GO:0043565//GO:0003700//GO:0050662//GO:0003824//GO:0016491 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//coenzyme binding//catalytic activity//oxidoreductase activity GO:0016020//GO:0005634//GO:0005667 membrane//nucleus//transcription factor complex -- -- Cluster-8309.36762 BF_2 1539.96 127.60 792 589060796 AHK26791.1 476 3.3e-45 eukaryotic translation initiation factor 4A [Epicauta chinensis] 630969033 XM_007882734.1 83 2.52099e-33 Pseudozyma flocculosa PF-1 hypothetical protein partial mRNA K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q3SZ54 433 1.3e-41 Eukaryotic initiation factor 4A-I OS=Bos taurus GN=EIF4A1 PE=2 SV=1 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG0327 Translation initiation factor 4F, helicase subunit (eIF-4A) and related helicases Cluster-8309.36763 BF_2 22405.00 145.27 6739 270007027 EFA03475.1 2744 2.9e-307 hypothetical protein TcasGA2_TC013472 [Tribolium castaneum] 642923411 XM_008195512.1 102 6.10457e-43 PREDICTED: Tribolium castaneum collagen alpha-2(IV) chain (LOC103313111), mRNA K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 P17140 2109 5.0e-235 Collagen alpha-2(IV) chain OS=Caenorhabditis elegans GN=let-2 PE=1 SV=2 PF06331//PF01413//PF04710 Transcription factor TFIIH complex subunit Tfb5//C-terminal tandem repeated domain in type 4 procollagen//Pellino GO:0008063//GO:0006289//GO:0006355 Toll signaling pathway//nucleotide-excision repair//regulation of transcription, DNA-templated GO:0005201 extracellular matrix structural constituent GO:0000439//GO:0005578//GO:0005581 core TFIIH complex//proteinaceous extracellular matrix//collagen trimer KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.36765 BF_2 9.05 4.20 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36768 BF_2 35.33 0.67 2478 642915413 XP_008190604.1 2751 1.6e-308 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform X1 [Tribolium castaneum] 768434134 XM_011560159.1 553 0 PREDICTED: Plutella xylostella H(+)/Cl(-) exchange transporter 5-like (LOC105389096), mRNA K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 P51792 1866 2.8e-207 H(+)/Cl(-) exchange transporter 3 OS=Rattus norvegicus GN=Clcn3 PE=2 SV=2 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.36769 BF_2 153.50 1.84 3779 478255961 ENN76162.1 1776 2.8e-195 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 Q8WY07 1135 2.5e-122 Cationic amino acid transporter 3 OS=Homo sapiens GN=SLC7A3 PE=1 SV=1 PF00324//PF15020//PF13520 Amino acid permease//Cation channel sperm-associated protein subunit delta//Amino acid permease GO:0006865//GO:0003333//GO:0055085//GO:0006810 amino acid transport//amino acid transmembrane transport//transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0036128//GO:0016020 CatSper complex//membrane -- -- Cluster-8309.36771 BF_2 1444.00 13.27 4840 91088817 XP_969793.1 2019 2.4e-223 PREDICTED: adenylosuccinate lyase [Tribolium castaneum]>gi|270012328|gb|EFA08776.1| hypothetical protein TcasGA2_TC006466 [Tribolium castaneum] 644999964 XM_001607942.3 153 1.95185e-71 PREDICTED: Nasonia vitripennis adenylosuccinate lyase (LOC100124133), mRNA K01756 purB, ADSL adenylosuccinate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01756 P21265 1603 1.7e-176 Adenylosuccinate lyase OS=Gallus gallus GN=ADSL PE=2 SV=2 PF01284//PF01607 Membrane-associating domain//Chitin binding Peritrophin-A domain GO:0006522//GO:0006144//GO:0006531//GO:0006030//GO:0009152 alanine metabolic process//purine nucleobase metabolic process//aspartate metabolic process//chitin metabolic process//purine ribonucleotide biosynthetic process GO:0008061//GO:0004018 chitin binding//N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity GO:0016020//GO:0005576 membrane//extracellular region KOG2700 Adenylosuccinate lyase Cluster-8309.36774 BF_2 5316.86 736.76 589 91080615 XP_974171.1 778 2.3e-80 PREDICTED: 60S ribosomal protein L21 [Tribolium castaneum]>gi|270005820|gb|EFA02268.1| hypothetical protein TcasGA2_TC007932 [Tribolium castaneum] -- -- -- -- -- K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 P46778 571 9.7e-58 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 PF01157 Ribosomal protein L21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.36775 BF_2 752.00 23.60 1620 571330966 AHF27415.1 878 1.6e-91 putative sugar transporter 3_1 [Phaedon cochleariae]>gi|571330968|gb|AHF27416.1| putative sugar transporter 3_2 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q7PIR5 438 7.0e-42 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.36776 BF_2 11880.56 478.41 1326 189240524 XP_971875.2 1968 5.4e-218 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] 62083392 AY961519.1 467 0 Lysiphlebus testaceipes ribosomal protein L3 (RpL3) mRNA, complete cds K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 1812 2.7e-201 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.36777 BF_2 182.77 1.17 6810 91084173 XP_966383.1 1434 2.3e-155 PREDICTED: serine/threonine-protein kinase pelle [Tribolium castaneum]>gi|270009272|gb|EFA05720.1| pelle [Tribolium castaneum] -- -- -- -- -- K04730 IRAK1 interleukin-1 receptor-associated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04730 Q05652 685 6.8e-70 Serine/threonine-protein kinase pelle OS=Drosophila melanogaster GN=pll PE=1 SV=1 PF07714//PF00531//PF00069 Protein tyrosine kinase//Death domain//Protein kinase domain GO:0007165//GO:0009987//GO:0006468 signal transduction//cellular process//protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- KOG1187 Serine/threonine protein kinase Cluster-8309.36778 BF_2 570.03 5.46 4655 642922405 XP_008193143.1 983 3.1e-103 PREDICTED: tetratricopeptide repeat protein 14 isoform X2 [Tribolium castaneum] 642922404 XM_008194921.1 226 4.93077e-112 PREDICTED: Tribolium castaneum tetratricopeptide repeat protein 14 (LOC663177), transcript variant X2, mRNA -- -- -- -- Q9VGU5 596 9.7e-60 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF01080//PF13181//PF11744//PF15741//PF05053//PF13174//PF13371//PF09726//PF02724//PF00515//PF13374//PF13176//PF10486//PF13414 Presenilin//Tetratricopeptide repeat//Aluminium activated malate transporter//Ligand-dependent nuclear receptor-interacting factor 1//Menin//Tetratricopeptide repeat//Tetratricopeptide repeat//Transmembrane protein//CDC45-like protein//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Phosphoinositide 3-kinase gamma adapter protein p101 subunit//TPR repeat GO:0015743//GO:0006270//GO:0007165//GO:0006355 malate transport//DNA replication initiation//signal transduction//regulation of transcription, DNA-templated GO:0042974//GO:0005515//GO:0004190//GO:0046935 retinoic acid receptor binding//protein binding//aspartic-type endopeptidase activity//1-phosphatidylinositol-3-kinase regulator activity GO:0005667//GO:0005634//GO:0016021//GO:0005944 transcription factor complex//nucleus//integral component of membrane//phosphatidylinositol 3-kinase complex, class IB -- -- Cluster-8309.36779 BF_2 3799.43 123.80 1571 264667413 ACY71292.1 697 1.5e-70 ribosomal protein L27 [Chrysomela tremula] 264667412 GU120442.1 190 1.68727e-92 Chrysomela tremulae ribosomal protein L27 (RpL27) mRNA, complete cds K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 P61355 503 2.0e-49 60S ribosomal protein L27 OS=Gallus gallus GN=RPL27 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3418 60S ribosomal protein L27 Cluster-8309.36780 BF_2 677.92 2.14 13539 642929047 XP_008195667.1 13173 0.0e+00 PREDICTED: baculoviral IAP repeat-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10586 BIRC6, BRUCE baculoviral IAP repeat-containing protein 6 (apollon) http://www.genome.jp/dbget-bin/www_bget?ko:K10586 O88738 3109 0.0e+00 Baculoviral IAP repeat-containing protein 6 OS=Mus musculus GN=Birc6 PE=1 SV=2 PF12356//PF00844 Protein of unknown function (DUF3643)//Geminivirus coat protein/nuclear export factor BR1 family GO:0032465//GO:0006915//GO:0016567 regulation of cytokinesis//apoptotic process//protein ubiquitination GO:0004842//GO:0005198 ubiquitin-protein transferase activity//structural molecule activity GO:0019028 viral capsid KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.36782 BF_2 33.71 0.43 3565 642915176 XP_008190506.1 292 3.2e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36783 BF_2 19489.39 394.84 2352 189237983 XP_001814292.1 711 5.5e-72 PREDICTED: filaggrin-2 [Tribolium castaneum]>gi|270006655|gb|EFA03103.1| hypothetical protein TcasGA2_TC013013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82120 156 5.1e-09 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.36784 BF_2 582.59 4.82 5339 817065189 XP_012254374.1 340 1.3e-28 PREDICTED: uncharacterized protein LOC105685104 [Athalia rosae] -- -- -- -- -- -- -- -- -- Q9YMJ7 236 6.1e-18 Envelope fusion protein OS=Lymantria dispar multicapsid nuclear polyhedrosis virus GN=LdOrf-130 PE=3 SV=1 PF05929//PF04111//PF07851//PF10186//PF01576//PF04728//PF04799//PF04857//PF01733 Phage capsid scaffolding protein (GPO) serine peptidase//Autophagy protein Apg6//TMPIT-like protein//Vacuolar sorting 38 and autophagy-related subunit 14//Myosin tail//Lipoprotein leucine-zipper//fzo-like conserved region//CAF1 family ribonuclease//Nucleoside transporter GO:0015858//GO:0006810//GO:0006914//GO:0008053//GO:0010508//GO:0019069 nucleoside transport//transport//autophagy//mitochondrial fusion//positive regulation of autophagy//viral capsid assembly GO:0003924//GO:0003774//GO:0005337 GTPase activity//motor activity//nucleoside transmembrane transporter activity GO:0019867//GO:0016459//GO:0016021//GO:0005634//GO:0005741 outer membrane//myosin complex//integral component of membrane//nucleus//mitochondrial outer membrane -- -- Cluster-8309.36786 BF_2 11348.41 35.90 13511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00770//PF05493 Adenovirus endoprotease//ATP synthase subunit H GO:0015992//GO:0015991//GO:0006508 proton transport//ATP hydrolysis coupled proton transport//proteolysis GO:0004197//GO:0015078 cysteine-type endopeptidase activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.36787 BF_2 9.33 1.26 597 642934971 XP_008196003.1 427 1.2e-39 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 41 4.16947e-10 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36788 BF_2 430.00 14.88 1496 91077308 XP_968724.1 686 2.8e-69 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001657|gb|EEZ98104.1| hypothetical protein TcasGA2_TC000517 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28493 476 2.5e-46 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36789 BF_2 7007.00 214.92 1651 91085025 XP_973732.1 2245 5.1e-250 PREDICTED: mitochondrial-processing peptidase subunit beta [Tribolium castaneum]>gi|270008520|gb|EFA04968.1| hypothetical protein TcasGA2_TC015046 [Tribolium castaneum] 332373533 BT126946.1 477 0 Dendroctonus ponderosae clone DPO022_F23 unknown mRNA K17732 PMPCB, MAS1 mitochondrial-processing peptidase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17732 Q3SZ71 1520 2.5e-167 Mitochondrial-processing peptidase subunit beta OS=Bos taurus GN=PMPCB PE=2 SV=1 PF08367 Peptidase M16C associated GO:0006508 proteolysis GO:0046872//GO:0004222//GO:0008270 metal ion binding//metalloendopeptidase activity//zinc ion binding -- -- KOG0960 Mitochondrial processing peptidase, beta subunit, and related enzymes (insulinase superfamily) Cluster-8309.36790 BF_2 8450.40 349.71 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36791 BF_2 79.88 0.92 3926 546683623 ERL93411.1 389 2.0e-34 hypothetical protein D910_10703 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16554 Dimerisation domain of d-ornithine 4,5-aminomutase -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.36793 BF_2 133.43 2.29 2725 189238186 XP_966734.2 2332 6.9e-260 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 768442048 XM_011564477.1 347 1.56469e-179 PREDICTED: Plutella xylostella coronin-6 (LOC105392798), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 3.4e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.36795 BF_2 985.44 15.24 2992 478257994 ENN78132.1 1444 7.0e-157 hypothetical protein YQE_05286, partial [Dendroctonus ponderosae] 815908496 XM_003488754.2 48 2.81013e-13 PREDICTED: Bombus impatiens protein SEC13 homolog (LOC100746611), mRNA K14004 SEC13 protein transport protein SEC13 http://www.genome.jp/dbget-bin/www_bget?ko:K14004 Q9D1M0 1099 2.9e-118 Protein SEC13 homolog OS=Mus musculus GN=Sec13 PE=2 SV=3 PF00400//PF16473//PF02538//PF00558 WD domain, G-beta repeat//Domain of unknown function (DUF5051)//Hydantoinase B/oxoprolinase//Vpu protein GO:0019076//GO:0006812//GO:0032801 viral release from host cell//cation transport//receptor catabolic process GO:0003824//GO:0005261//GO:0005515//GO:0003676 catalytic activity//cation channel activity//protein binding//nucleic acid binding GO:0033644 host cell membrane KOG1332 Vesicle coat complex COPII, subunit SEC13 Cluster-8309.36796 BF_2 29601.00 848.23 1747 556505459 YP_008757556.1 934 5.6e-98 NADH dehydrogenase subunit 2 (mitochondrion) [Batocera lineolata]>gi|359294282|gb|AEV21651.1| NADH dehydrogenase subunit 2 [Batocera lineolata] 359294281 JN986793.1 1081 0 Batocera lineolata mitochondrion, complete genome K03879 ND2 NADH-ubiquinone oxidoreductase chain 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03879 P03895 421 7.1e-40 NADH-ubiquinone oxidoreductase chain 2 OS=Drosophila yakuba GN=mt:ND2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36797 BF_2 6326.31 32.16 8516 478252904 ENN73288.1 2585 9.9e-289 hypothetical protein YQE_10052, partial [Dendroctonus ponderosae] 332373611 BT126985.1 410 0 Dendroctonus ponderosae clone DPO0910_M08 unknown mRNA K05677 ABCD3, PMP70 ATP-binding cassette, subfamily D (ALD), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05677 P28288 1838 1.7e-203 ATP-binding cassette sub-family D member 3 OS=Homo sapiens GN=ABCD3 PE=1 SV=1 PF00005//PF00262//PF06448//PF09266//PF13304//PF07127//PF02854//PF06472 ABC transporter//Calreticulin family//Domain of Unknown Function (DUF1081)//Viral DNA topoisomerase I, N-terminal//AAA domain, putative AbiEii toxin, Type IV TA system//Late nodulin protein//MIF4G domain//ABC transporter transmembrane region 2 GO:0009878//GO:0006869//GO:0006457//GO:0006265//GO:0006810//GO:0055085 nodule morphogenesis//lipid transport//protein folding//DNA topological change//transport//transmembrane transport GO:0046872//GO:0005509//GO:0005515//GO:0003916//GO:0005319//GO:0003677//GO:0003723//GO:0042626//GO:0016887//GO:0051082//GO:0005524 metal ion binding//calcium ion binding//protein binding//DNA topoisomerase activity//lipid transporter activity//DNA binding//RNA binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//unfolded protein binding//ATP binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) Cluster-8309.36799 BF_2 211.24 1.83 5114 642932256 XP_008197035.1 1291 6.6e-139 PREDICTED: uncharacterized protein CG7065 homolog isoform X2 [Tribolium castaneum] 805785462 XM_012284975.1 63 2.21442e-21 PREDICTED: Megachile rotundata uncharacterized protein CG7065-like (LOC100874663), transcript variant X3, mRNA -- -- -- -- Q7YZA2 382 6.9e-35 Uncharacterized protein CG7065 OS=Drosophila melanogaster GN=CG7065 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.368 BF_2 15.00 1.68 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36800 BF_2 624.00 3.34 8100 642921046 XP_008192669.1 7635 0.0e+00 PREDICTED: low-density lipoprotein receptor-related protein 4 isoform X2 [Tribolium castaneum]>gi|270005136|gb|EFA01584.1| hypothetical protein TcasGA2_TC007146 [Tribolium castaneum] 642921045 XM_008194447.1 65 2.71728e-22 PREDICTED: Tribolium castaneum low-density lipoprotein receptor-related protein 4 (LOC663741), transcript variant X2, mRNA -- -- -- -- O75096 4284 0.0e+00 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF01731//PF00057//PF07645//PF02796 Arylesterase//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Helix-turn-helix domain of resolvase GO:0006310 DNA recombination GO:0000150//GO:0004064//GO:0005515//GO:0005509//GO:0003677 recombinase activity//arylesterase activity//protein binding//calcium ion binding//DNA binding GO:0016021 integral component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.36801 BF_2 12246.67 225.70 2557 91081945 XP_966990.1 2785 0.0e+00 PREDICTED: ATP-binding cassette sub-family F member 2 [Tribolium castaneum]>gi|270007325|gb|EFA03773.1| hypothetical protein TcasGA2_TC013884 [Tribolium castaneum] 642921870 XM_961897.3 497 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family F member 2 (LOC655357), mRNA K06185 ABCF2 ATP-binding cassette, subfamily F, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06185 Q9UG63 2156 6.8e-241 ATP-binding cassette sub-family F member 2 OS=Homo sapiens GN=ABCF2 PE=1 SV=2 PF00025//PF01716//PF00004//PF13304//PF01926//PF00910//PF03969//PF06414//PF03193//PF00005 ADP-ribosylation factor family//Manganese-stabilising protein / photosystem II polypeptide//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//RNA helicase//AFG1-like ATPase//Zeta toxin//Protein of unknown function, DUF258//ABC transporter GO:0015979//GO:0006200//GO:0042549 photosynthesis//obsolete ATP catabolic process//photosystem II stabilization GO:0003723//GO:0005524//GO:0003924//GO:0016887//GO:0016301//GO:0005509//GO:0005525//GO:0003724 RNA binding//ATP binding//GTPase activity//ATPase activity//kinase activity//calcium ion binding//GTP binding//RNA helicase activity GO:0019898//GO:0009654//GO:0009523 extrinsic component of membrane//photosystem II oxygen evolving complex//photosystem II KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.36802 BF_2 702.90 7.10 4428 642912483 XP_008200883.1 2111 4.7e-234 PREDICTED: protein hu-li tai shao isoform X1 [Tribolium castaneum] 752873776 XM_011255881.1 55 5.36297e-17 PREDICTED: Camponotus floridanus protein hu-li tai shao (LOC105250025), transcript variant X7, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1443 5.6e-158 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36804 BF_2 420.69 2.62 6999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00641//PF00894 Zn-finger in Ran binding protein and others//Luteovirus coat protein -- -- GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.36805 BF_2 989.97 6.11 7069 642914570 XP_008190269.1 2875 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 10-like [Tribolium castaneum] -- -- -- -- -- K09530 DNAJC10 DnaJ homolog subfamily C member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09530 Q498R3 1401 6.6e-153 DnaJ homolog subfamily C member 10 OS=Rattus norvegicus GN=Dnajc10 PE=2 SV=2 PF01216//PF00085//PF08534//PF00578 Calsequestrin//Thioredoxin//Redoxin//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0005509//GO:0016491 antioxidant activity//calcium ion binding//oxidoreductase activity -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.36806 BF_2 2941.78 18.72 6862 189237348 XP_969332.2 5697 0.0e+00 PREDICTED: UDP-glucose:glycoprotein glucosyltransferase [Tribolium castaneum]>gi|642923178|ref|XP_008193642.1| PREDICTED: UDP-glucose:glycoprotein glucosyltransferase [Tribolium castaneum] 815794682 XM_012362561.1 201 5.75118e-98 PREDICTED: Linepithema humile UDP-glucose:glycoprotein glucosyltransferase (LOC105669544), mRNA K11718 HUGT UDP-glucose:glycoprotein glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11718 Q09332 3802 0.0e+00 UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster GN=Ugt PE=1 SV=2 PF00110//PF01501//PF00230//PF06427 wnt family//Glycosyl transferase family 8//Major intrinsic protein//UDP-glucose:Glycoprotein Glucosyltransferase GO:0006486//GO:0006810//GO:0016055//GO:0007275//GO:0007165 protein glycosylation//transport//Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102//GO:0003980//GO:0005215//GO:0016757 receptor binding//UDP-glucose:glycoprotein glucosyltransferase activity//transporter activity//transferase activity, transferring glycosyl groups GO:0016020//GO:0005576 membrane//extracellular region KOG1879 UDP-glucose:glycoprotein glucosyltransferase Cluster-8309.36810 BF_2 886.21 3.60 10583 642911349 XP_008199384.1 4646 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X1 [Tribolium castaneum] 642911358 XM_008201167.1 137 3.3585e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 1.9e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36811 BF_2 33.25 0.51 3021 795072296 XP_011875580.1 268 1.6e-20 PREDICTED: protein vein isoform X2 [Vollenhovia emeryi] 642924274 XM_008196005.1 39 2.85784e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103313241 (LOC103313241), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00008//PF07645//PF13895 EGF-like domain//Calcium-binding EGF domain//Immunoglobulin domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.36813 BF_2 1388.10 53.77 1367 642935794 XP_008198177.1 361 1.2e-31 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35566 196 6.8e-14 CD151 antigen OS=Mus musculus GN=Cd151 PE=2 SV=2 PF00335//PF02203 Tetraspanin family//Tar ligand binding domain homologue GO:0007165//GO:0006935 signal transduction//chemotaxis GO:0004888 transmembrane signaling receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.36816 BF_2 149.53 1.30 5096 642917385 XP_008199669.1 1771 1.4e-194 PREDICTED: uncharacterized protein LOC658463 [Tribolium castaneum]>gi|270003013|gb|EEZ99460.1| hypothetical protein TcasGA2_TC000026 [Tribolium castaneum] -- -- -- -- -- K18586 COQ4 ubiquinone biosynthesis protein COQ4 http://www.genome.jp/dbget-bin/www_bget?ko:K18586 Q1HPV1 735 8.1e-76 Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial OS=Bombyx mori PE=2 SV=1 PF05271//PF05019 Tobravirus 2B protein//Coenzyme Q (ubiquinone) biosynthesis protein Coq4 GO:0006744//GO:0019089 ubiquinone biosynthetic process//transmission of virus -- -- -- -- KOG3244 Protein involved in ubiquinone biosynthesis Cluster-8309.36817 BF_2 49.42 0.77 2959 478260219 ENN79982.1 167 8.3e-09 hypothetical protein YQE_03576, partial [Dendroctonus ponderosae]>gi|546675213|gb|ERL86449.1| hypothetical protein D910_03856 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36818 BF_2 1658.40 15.84 4667 91077504 XP_966852.1 2801 0.0e+00 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 406 1.0e-37 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184//PF02627 Saposin-like type B, region 1//Carboxymuconolactone decarboxylase family GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.36819 BF_2 250.68 0.99 10898 642940144 XP_008200104.1 3309 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 1673 2.9e-184 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 PF04841//PF04840 Vps16, N-terminal region//Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.36820 BF_2 4091.00 154.34 1396 642913031 XP_008201359.1 654 1.3e-65 PREDICTED: proclotting enzyme-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81187 151 1.2e-08 Complement factor B OS=Bos taurus GN=CFB PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.36821 BF_2 20149.00 339.62 2769 91087467 XP_966334.1 2492 2.0e-278 PREDICTED: ATP synthase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270010980|gb|EFA07428.1| hypothetical protein TcasGA2_TC008728 [Tribolium castaneum] 807044009 XM_004537394.2 644 0 PREDICTED: Ceratitis capitata ATP synthase subunit alpha, mitochondrial (LOC101456141), mRNA K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 P80021 2216 8.1e-248 ATP synthase subunit alpha, mitochondrial OS=Sus scrofa GN=ATP5A1 PE=1 SV=2 PF02874//PF00306//PF00006 ATP synthase alpha/beta family, beta-barrel domain//ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, nucleotide-binding domain GO:0015991//GO:0006119//GO:0046034//GO:0015992//GO:0015986 ATP hydrolysis coupled proton transport//oxidative phosphorylation//ATP metabolic process//proton transport//ATP synthesis coupled proton transport GO:0016820//GO:0005524//GO:0046961//GO:0046933 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//ATP binding//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0033178//GO:0045261 proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain//proton-transporting ATP synthase complex, catalytic core F(1) KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-8309.36824 BF_2 49091.02 209.66 10082 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF08165//PF01436//PF14634//PF03884//PF01601//PF00097//PF04513//PF13639//PF04566//PF10588//PF00651 FerA (NUC095) domain//NHL repeat//zinc-RING finger domain//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//Zinc finger, C3HC4 type (RING finger)//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//BTB/POZ domain GO:0055114//GO:0046813//GO:0006206//GO:0061025//GO:0006144//GO:0006351 oxidation-reduction process//receptor-mediated virion attachment to host cell//pyrimidine nucleobase metabolic process//membrane fusion//purine nucleobase metabolic process//transcription, DNA-templated GO:0008270//GO:0005198//GO:0003899//GO:0046872//GO:0016491//GO:0005515//GO:0003677 zinc ion binding//structural molecule activity//DNA-directed RNA polymerase activity//metal ion binding//oxidoreductase activity//protein binding//DNA binding GO:0005730//GO:0019028//GO:0016021//GO:0019031 nucleolus//viral capsid//integral component of membrane//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.36825 BF_2 2142.94 45.98 2237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36826 BF_2 3340.35 34.39 4350 478263033 ENN81433.1 728 1.1e-73 hypothetical protein YQE_02126, partial [Dendroctonus ponderosae]>gi|546686062|gb|ERL95462.1| hypothetical protein D910_12724 [Dendroctonus ponderosae] 831528427 XM_012864660.1 115 2.33242e-50 PREDICTED: Fundulus heteroclitus malate dehydrogenase 2, NAD (mitochondrial) (mdh2), mRNA K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 P40926 510 8.5e-50 Malate dehydrogenase, mitochondrial OS=Homo sapiens GN=MDH2 PE=1 SV=3 PF01073//PF02866//PF01113//PF00056//PF02882 3-beta hydroxysteroid dehydrogenase/isomerase family//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Dihydrodipicolinate reductase, N-terminus//lactate/malate dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0008210//GO:0009089//GO:0009085//GO:0046487//GO:0009396//GO:0008207//GO:0055114//GO:0006694//GO:0008209 estrogen metabolic process//lysine biosynthetic process via diaminopimelate//lysine biosynthetic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process GO:0003854//GO:0003824//GO:0008839//GO:0016616//GO:0004488//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//4-hydroxy-tetrahydrodipicolinate reductase//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.36827 BF_2 140.96 0.71 8587 478252904 ENN73288.1 2609 1.6e-291 hypothetical protein YQE_10052, partial [Dendroctonus ponderosae] 332373611 BT126985.1 410 0 Dendroctonus ponderosae clone DPO0910_M08 unknown mRNA K05677 ABCD3, PMP70 ATP-binding cassette, subfamily D (ALD), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05677 P28288 1838 1.7e-203 ATP-binding cassette sub-family D member 3 OS=Homo sapiens GN=ABCD3 PE=1 SV=1 PF13304//PF07127//PF02854//PF06472//PF00005//PF00262//PF06448//PF09266 AAA domain, putative AbiEii toxin, Type IV TA system//Late nodulin protein//MIF4G domain//ABC transporter transmembrane region 2//ABC transporter//Calreticulin family//Domain of Unknown Function (DUF1081)//Viral DNA topoisomerase I, N-terminal GO:0009878//GO:0006457//GO:0006869//GO:0006265//GO:0055085//GO:0006810 nodule morphogenesis//protein folding//lipid transport//DNA topological change//transmembrane transport//transport GO:0005509//GO:0046872//GO:0003723//GO:0003677//GO:0005319//GO:0003916//GO:0005515//GO:0051082//GO:0016887//GO:0042626//GO:0005524 calcium ion binding//metal ion binding//RNA binding//DNA binding//lipid transporter activity//DNA topoisomerase activity//protein binding//unfolded protein binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG0060 Long-chain acyl-CoA transporter, ABC superfamily (involved in peroxisome organization and biogenesis) Cluster-8309.36828 BF_2 5319.26 39.81 5877 642935884 XP_008198212.1 3942 0.0e+00 PREDICTED: sterile alpha and TIR motif-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IDD9 2775 1.9e-312 Sterile alpha and TIR motif-containing protein 1 OS=Drosophila melanogaster GN=Ect4 PE=2 SV=1 PF00514//PF06624//PF00536//PF07647//PF13676 Armadillo/beta-catenin-like repeat//Ribosome associated membrane protein RAMP4//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG3678 SARM protein (with sterile alpha and armadillo motifs) Cluster-8309.36830 BF_2 1527.91 14.63 4656 642914862 XP_008195074.1 2183 2.2e-242 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q28824 825 2.7e-86 Myosin light chain kinase, smooth muscle OS=Bos taurus GN=MYLK PE=1 SV=1 PF07714//PF00069//PF00631//PF06293 Protein tyrosine kinase//Protein kinase domain//GGL domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0007186//GO:0007165//GO:0006468 G-protein coupled receptor signaling pathway//signal transduction//protein phosphorylation GO:0004871//GO:0016773//GO:0004672//GO:0005524 signal transducer activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding GO:0016020//GO:0005834 membrane//heterotrimeric G-protein complex KOG0613 Projectin/twitchin and related proteins Cluster-8309.36831 BF_2 269.10 1.30 8968 91083999 XP_975264.1 1320 5.0e-142 PREDICTED: protein FAM13A [Tribolium castaneum]>gi|270006707|gb|EFA03155.1| hypothetical protein TcasGA2_TC013074 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYW0 267 2.6e-21 Protein FAM13A OS=Bos taurus GN=FAM13A PE=2 SV=1 PF11365 Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy -- -- GO:0005615 extracellular space -- -- Cluster-8309.36832 BF_2 16316.01 98.95 7185 546673612 ERL85176.1 11605 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911110 XM_008202361.1 2073 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 5750 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF01108//PF03739//PF13895//PF00041//PF02480//PF16656 Tissue factor//Predicted permease YjgP/YjgQ family//Immunoglobulin domain//Fibronectin type III domain//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.36833 BF_2 44.84 1.86 1294 264667343 ACY71257.1 1048 2.5e-111 ribosomal protein L6 [Chrysomela tremula] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q2YGT9 558 6.8e-56 60S ribosomal protein L6 OS=Sus scrofa GN=RPL6 PE=1 SV=3 PF03868//PF01159 Ribosomal protein L6, N-terminal domain//Ribosomal protein L6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1694 60s ribosomal protein L6 Cluster-8309.36835 BF_2 204.81 0.86 10258 546678611 ERL89193.1 1276 7.3e-137 hypothetical protein D910_06567 [Dendroctonus ponderosae] -- -- -- -- -- K00129 E1.2.1.5 aldehyde dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00129 P30838 1036 2.0e-110 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Homo sapiens GN=ALDH3A1 PE=1 SV=3 PF00106//PF08656//PF01370//PF02558//PF07690//PF00171 short chain dehydrogenase//DASH complex subunit Dad3//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//Major Facilitator Superfamily//Aldehyde dehydrogenase family GO:0008152//GO:0015940//GO:0055085//GO:0008608//GO:0055114 metabolic process//pantothenate biosynthetic process//transmembrane transport//attachment of spindle microtubules to kinetochore//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491//GO:0008677 coenzyme binding//catalytic activity//oxidoreductase activity//2-dehydropantoate 2-reductase activity GO:0016021//GO:0072686//GO:0042729 integral component of membrane//mitotic spindle//DASH complex KOG2456 Aldehyde dehydrogenase Cluster-8309.36836 BF_2 12.39 0.38 1645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36838 BF_2 2871.49 24.30 5231 642924644 XP_008194377.1 4519 0.0e+00 PREDICTED: tensin isoform X3 [Tribolium castaneum] 642924663 XM_008196165.1 42 1.06903e-09 PREDICTED: Tribolium castaneum tensin (LOC663789), transcript variant X13, mRNA K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q04205 811 1.3e-84 Tensin OS=Gallus gallus GN=TNS PE=1 SV=2 PF08416 Phosphotyrosine-binding domain -- -- GO:0005515 protein binding -- -- KOG1930 Focal adhesion protein Tensin, contains PTB domain Cluster-8309.36839 BF_2 3585.06 23.50 6668 642922678 XP_008193276.1 5040 0.0e+00 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X8 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 1706 2.7e-188 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF13895//PF02443//PF00057//PF01086//PF00815//PF10584 Immunoglobulin domain//Circovirus capsid protein//Low-density lipoprotein receptor domain class A//Clathrin light chain//Histidinol dehydrogenase//Proteasome subunit A N-terminal signature GO:0006511//GO:0000105//GO:0019069//GO:0016192//GO:0006886//GO:0055114 ubiquitin-dependent protein catabolic process//histidine biosynthetic process//viral capsid assembly//vesicle-mediated transport//intracellular protein transport//oxidation-reduction process GO:0051287//GO:0005515//GO:0004175//GO:0005198//GO:0004399//GO:0008270 NAD binding//protein binding//endopeptidase activity//structural molecule activity//histidinol dehydrogenase activity//zinc ion binding GO:0030132//GO:0042025//GO:0019773//GO:0030130 clathrin coat of coated pit//host cell nucleus//proteasome core complex, alpha-subunit complex//clathrin coat of trans-Golgi network vesicle KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.36841 BF_2 31676.85 278.75 5041 332375044 AEE62663.1 3535 0.0e+00 unknown [Dendroctonus ponderosae]>gi|478250038|gb|ENN70544.1| hypothetical protein YQE_12719, partial [Dendroctonus ponderosae]>gi|546672620|gb|ERL84416.1| hypothetical protein D910_01849 [Dendroctonus ponderosae] 642932042 XM_969767.3 504 0 PREDICTED: Tribolium castaneum probable aconitate hydratase, mitochondrial (LOC663732), mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 Q99KI0 3035 0.0e+00 Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1 PF00330//PF00694 Aconitase family (aconitate hydratase)//Aconitase C-terminal domain GO:0008152 metabolic process -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.36845 BF_2 31.83 0.36 3994 642910971 XP_008193488.1 486 1.1e-45 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O95359 166 6.0e-10 Transforming acidic coiled-coil-containing protein 2 OS=Homo sapiens GN=TACC2 PE=1 SV=3 PF08702//PF12740//PF07224//PF16719//PF11744//PF10186//PF07851//PF04632 Fibrinogen alpha/beta chain family//Chlorophyllase enzyme//Chlorophyllase//SAWADEE domain//Aluminium activated malate transporter//Vacuolar sorting 38 and autophagy-related subunit 14//TMPIT-like protein//Fusaric acid resistance protein family GO:0010508//GO:0006810//GO:0051258//GO:0015996//GO:0007165//GO:0030168//GO:0015994//GO:0015743 positive regulation of autophagy//transport//protein polymerization//chlorophyll catabolic process//signal transduction//platelet activation//chlorophyll metabolic process//malate transport GO:0003682//GO:0005102//GO:0030674//GO:0047746 chromatin binding//receptor binding//protein binding, bridging//chlorophyllase activity GO:0005577//GO:0016021//GO:0005886//GO:0000785 fibrinogen complex//integral component of membrane//plasma membrane//chromatin -- -- Cluster-8309.36846 BF_2 4983.21 68.04 3351 613485521 AHX26755.1 494 1.1e-46 ATF4 [Tribolium castaneum] 462302759 APGK01050095.1 54 1.45587e-16 Dendroctonus ponderosae Seq01050105, whole genome shotgun sequence K04374 ATF4, CREB2 cyclic AMP-dependent transcription factor ATF-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04374 Q9GPH3 194 2.9e-13 Activating transcription factor of chaperone OS=Bombyx mori GN=ATFC PE=2 SV=1 PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.36847 BF_2 518.41 11.74 2134 642922261 XP_008193083.1 862 1.5e-89 PREDICTED: leucine-rich repeat and calponin homology domain-containing protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P62046 418 1.9e-39 Leucine-rich repeat and calponin homology domain-containing protein 1 OS=Mus musculus GN=Lrch1 PE=1 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0532 Leucine-rich repeat (LRR) protein, contains calponin homology domain Cluster-8309.36850 BF_2 3770.71 26.84 6165 478260998 ENN80588.1 6830 0.0e+00 hypothetical protein YQE_02993, partial [Dendroctonus ponderosae] 884965815 XM_010892944.2 162 2.47264e-76 PREDICTED: Esox lucius HECT domain containing E3 ubiquitin protein ligase 1 (hectd1), transcript variant X6, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 4691 0.0e+00 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF13606//PF00023//PF06701 Ankyrin repeat//Ankyrin repeat//Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515 ubiquitin-protein transferase activity//metal ion binding//protein binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.36851 BF_2 192.16 1.50 5645 642940435 XP_008194234.1 2341 1.3e-260 PREDICTED: rho GTPase-activating protein 26, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZMW5 1504 6.0e-165 Rho GTPase-activating protein 26 OS=Gallus gallus GN=ARHGAP26 PE=1 SV=2 PF01956//PF03155//PF03114//PF00620//PF01297 Integral membrane protein DUF106//ALG6, ALG8 glycosyltransferase family//BAR domain//RhoGAP domain//Zinc-uptake complex component A periplasmic GO:0030001//GO:0007165 metal ion transport//signal transduction GO:0016758//GO:0005515//GO:0046872 transferase activity, transferring hexosyl groups//protein binding//metal ion binding GO:0005789//GO:0016020//GO:0005737 endoplasmic reticulum membrane//membrane//cytoplasm KOG1451 Oligophrenin-1 and related Rho GTPase-activating proteins Cluster-8309.36852 BF_2 625.31 53.62 775 478252045 ENN72476.1 632 2.6e-63 hypothetical protein YQE_10818, partial [Dendroctonus ponderosae] 241606024 XM_002406107.1 38 2.55318e-08 Ixodes scapularis merlin, putative, mRNA K16684 NF2 merlin http://www.genome.jp/dbget-bin/www_bget?ko:K16684 Q24564 228 7.5e-18 Moesin/ezrin/radixin homolog 2 OS=Drosophila melanogaster GN=Mer PE=1 SV=1 PF00769//PF03497 Ezrin/radixin/moesin family//Anthrax toxin LF subunit GO:0006171//GO:0009405 cAMP biosynthetic process//pathogenesis GO:0008294//GO:0008092 calcium- and calmodulin-responsive adenylate cyclase activity//cytoskeletal protein binding GO:0005737//GO:0005576//GO:0019898 cytoplasm//extracellular region//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.36853 BF_2 3381.99 271.11 809 642933931 XP_008197572.1 570 4.2e-56 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 233 2.1e-18 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- -- -- Cluster-8309.36854 BF_2 53.68 0.64 3819 546675355 ERL86565.1 422 2.9e-38 hypothetical protein D910_03972 [Dendroctonus ponderosae] 573889931 XM_006632666.1 92 1.24851e-37 PREDICTED: Lepisosteus oculatus zinc finger protein 36, C3H1 type-like 1-like (LOC102685396), mRNA K18753 ZFP36L butyrate response factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18753 Q07352 267 1.1e-21 Zinc finger protein 36, C3H1 type-like 1 OS=Homo sapiens GN=ZFP36L1 PE=1 SV=1 PF03791//PF00642 KNOX2 domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634 nucleus KOG1677 CCCH-type Zn-finger protein Cluster-8309.36855 BF_2 257.57 0.98 11250 642913459 XP_008201021.1 2877 0.0e+00 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 192 9.51586e-93 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 507 4.9e-49 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF05206//PF03169 Methyltransferase TRM13//OPT oligopeptide transporter protein GO:0055085//GO:0008033 transmembrane transport//tRNA processing GO:0008168 methyltransferase activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.36856 BF_2 172.37 0.68 10963 642913459 XP_008201021.1 2877 0.0e+00 PREDICTED: uncharacterized protein LOC103315067 [Tribolium castaneum] 642913458 XM_008202799.1 148 2.67087e-68 PREDICTED: Tribolium castaneum uncharacterized LOC103315067 (LOC103315067), mRNA K00831 serC, PSAT1 phosphoserine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00831 Q9VAN0 1068 4.2e-114 Probable phosphoserine aminotransferase OS=Drosophila melanogaster GN=CG11899 PE=2 SV=1 PF03169//PF03334//PF03581 OPT oligopeptide transporter protein//Na+/H+ antiporter subunit//Herpesvirus UL33-like protein GO:0019073//GO:0015992//GO:0015672//GO:0055085 viral DNA genome packaging//proton transport//monovalent inorganic cation transport//transmembrane transport GO:0005451 monovalent cation:proton antiporter activity -- -- KOG2790 Phosphoserine aminotransferase Cluster-8309.36858 BF_2 896.05 6.69 5891 642938612 XP_008199865.1 2521 1.8e-281 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.36859 BF_2 2062.11 19.93 4616 642928992 XP_008195647.1 2657 2.4e-297 PREDICTED: endoplasmic reticulum metallopeptidase 1-like [Tribolium castaneum] 642930260 XM_966256.3 104 3.22596e-44 PREDICTED: Tribolium castaneum 40S ribosomal protein S29 (LOC659992), mRNA -- -- -- -- Q3UVK0 1041 2.4e-111 Endoplasmic reticulum metallopeptidase 1 OS=Mus musculus GN=Ermp1 PE=2 SV=2 PF01546//PF15957//PF00253//PF00060//PF15168 Peptidase family M20/M25/M40//Commissureless//Ribosomal protein S14p/S29e//Ligand-gated ion channel//Triple QxxK/R motif-containing protein family GO:0006811//GO:0042254//GO:0007411//GO:0007165//GO:0008152//GO:0006412//GO:0007268 ion transport//ribosome biogenesis//axon guidance//signal transduction//metabolic process//translation//synaptic transmission GO:0003735//GO:0016787//GO:0004970 structural constituent of ribosome//hydrolase activity//ionotropic glutamate receptor activity GO:0016020//GO:0005622//GO:0005840//GO:0005789 membrane//intracellular//ribosome//endoplasmic reticulum membrane KOG2194 Aminopeptidases of the M20 family Cluster-8309.36861 BF_2 892.76 10.73 3769 478263359 ENN81735.1 159 9.0e-08 hypothetical protein YQE_01874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36862 BF_2 5487.00 23.82 9922 91088831 XP_970461.1 3072 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X1 [Tribolium castaneum]>gi|270012333|gb|EFA08781.1| hypothetical protein TcasGA2_TC006471 [Tribolium castaneum] 645001221 XM_001601899.3 112 2.48575e-48 PREDICTED: Nasonia vitripennis 60S ribosomal protein L34-like (LOC100113629), mRNA K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O88813 1719 1.2e-189 Long-chain-fatty-acid--CoA ligase 5 OS=Rattus norvegicus GN=Acsl5 PE=1 SV=1 PF01199//PF00501//PF05008//PF01363//PF16053 Ribosomal protein L34e//AMP-binding enzyme//Vesicle transport v-SNARE protein N-terminus//FYVE zinc finger//Mitochondrial 28S ribosomal protein S34 GO:0042254//GO:0008152//GO:0006412//GO:0006886 ribosome biogenesis//metabolic process//translation//intracellular protein transport GO:0003735//GO:0046872//GO:0003824 structural constituent of ribosome//metal ion binding//catalytic activity GO:0016020//GO:0005622//GO:0005840//GO:0005739 membrane//intracellular//ribosome//mitochondrion KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-8309.36863 BF_2 95.43 0.91 4677 189241960 XP_968710.2 3341 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 9 isoform X2 [Tribolium castaneum] 805759873 XM_012297744.1 247 1.04989e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 1.9e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.36864 BF_2 41.11 1.98 1156 820805582 AKG92782.1 545 4.8e-53 Pxs [Leptinotarsa decemlineata] 564234777 XM_006274259.1 76 2.90518e-29 PREDICTED: Alligator mississippiensis transcription factor 15 (basic helix-loop-helix) (TCF15), mRNA K09070 TCF15, PARAXIS transcription factor 15 http://www.genome.jp/dbget-bin/www_bget?ko:K09070 Q60539 276 3.1e-23 Transcription factor 15 OS=Mesocricetus auratus GN=TCF15 PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.36865 BF_2 4394.85 20.06 9450 332375166 AEE62724.1 996 2.0e-104 unknown [Dendroctonus ponderosae]>gi|478252403|gb|ENN72829.1| hypothetical protein YQE_10632, partial [Dendroctonus ponderosae]>gi|546680735|gb|ERL90961.1| hypothetical protein D910_08303 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 736 1.1e-75 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF10371//PF01073//PF01118//PF03015//PF13855//PF09107//PF01370//PF03435 Domain of unknown function//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//Male sterility protein//Leucine rich repeat//Elongation factor SelB, winged helix//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain GO:0008210//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0001514//GO:0006448 estrogen metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//selenocysteine incorporation//regulation of translational elongation GO:0005525//GO:0003746//GO:0003723//GO:0003824//GO:0051287//GO:0016491//GO:0005515//GO:0080019//GO:0016620//GO:0016903//GO:0003854//GO:0050662//GO:0016616 GTP binding//translation elongation factor activity//RNA binding//catalytic activity//NAD binding//oxidoreductase activity//protein binding//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity, acting on the aldehyde or oxo group of donors//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005840//GO:0005737 ribosome//cytoplasm KOG1221 Acyl-CoA reductase Cluster-8309.36866 BF_2 954.44 12.04 3603 642925601 XP_001812139.2 166 1.3e-08 PREDICTED: uncharacterized protein LOC660114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80060 132 4.8e-06 Protease inhibitors OS=Locusta migratoria PE=1 SV=2 PF04901//PF04048//PF05375 Receptor activity modifying family//Sec8 exocyst complex component specific domain//Pacifastin inhibitor (LCMII) GO:0015031//GO:0006886//GO:0006904//GO:0008277 protein transport//intracellular protein transport//vesicle docking involved in exocytosis//regulation of G-protein coupled receptor protein signaling pathway GO:0030414//GO:0008565 peptidase inhibitor activity//protein transporter activity GO:0000145//GO:0016021 exocyst//integral component of membrane -- -- Cluster-8309.36868 BF_2 7986.08 95.62 3781 752876259 XP_011255518.1 494 1.3e-46 PREDICTED: 60S ribosomal protein L44 [Camponotus floridanus] 642918893 XM_968530.2 160 1.95441e-75 PREDICTED: Tribolium castaneum 60S ribosomal protein L44 (LOC662436), mRNA K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 450 6.7e-43 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF02150//PF10152//PF00935 RNA polymerases M/15 Kd subunit//Predicted coiled-coil domain-containing protein (DUF2360)//Ribosomal protein L44 GO:0042254//GO:0006206//GO:0006412//GO:0006144//GO:0006351 ribosome biogenesis//pyrimidine nucleobase metabolic process//translation//purine nucleobase metabolic process//transcription, DNA-templated GO:0003735//GO:0003677//GO:0003899 structural constituent of ribosome//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0071203//GO:0005622//GO:0005840 nucleolus//WASH complex//intracellular//ribosome KOG3464 60S ribosomal protein L44 Cluster-8309.36869 BF_2 679.84 11.82 2693 642927468 XP_008195285.1 829 1.3e-85 PREDICTED: growth arrest-specific protein 1-like [Tribolium castaneum]>gi|270009958|gb|EFA06406.1| hypothetical protein TcasGA2_TC009285 [Tribolium castaneum] -- -- -- -- -- K06232 GAS1 growth arrest-specific 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06232 Q01721 262 3.0e-21 Growth arrest-specific protein 1 OS=Mus musculus GN=Gas1 PE=2 SV=2 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36870 BF_2 210.85 18.85 755 642931818 XP_008196746.1 346 3.7e-30 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q3THK7 282 4.0e-24 GMP synthase [glutamine-hydrolyzing] OS=Mus musculus GN=Gmps PE=1 SV=2 PF00958 GMP synthase C terminal domain GO:0006536//GO:0006144//GO:0006164//GO:0006177 glutamate metabolic process//purine nucleobase metabolic process//purine nucleotide biosynthetic process//GMP biosynthetic process GO:0003922//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//ATP binding -- -- KOG1622 GMP synthase Cluster-8309.36871 BF_2 3584.15 31.31 5076 642925960 XP_008195671.1 2730 9.1e-306 PREDICTED: neurotrypsin-like [Tribolium castaneum]>gi|270009237|gb|EFA05685.1| serine protease P153 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08762 744 7.3e-77 Neurotrypsin OS=Mus musculus GN=Prss12 PE=2 SV=1 PF00057//PF00530//PF01607//PF15494//PF00089//PF01380 Low-density lipoprotein receptor domain class A//Scavenger receptor cysteine-rich domain//Chitin binding Peritrophin-A domain//Scavenger receptor cysteine-rich domain//Trypsin//SIS domain GO:0006508//GO:0005975//GO:0007165//GO:0006030 proteolysis//carbohydrate metabolic process//signal transduction//chitin metabolic process GO:0030246//GO:0008061//GO:0008233//GO:0004252//GO:0005044//GO:0005515 carbohydrate binding//chitin binding//peptidase activity//serine-type endopeptidase activity//scavenger receptor activity//protein binding GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.36875 BF_2 142.46 1.91 3405 674656865 AIL26079.1 747 5.3e-76 ferritin 2 [Monochamus alternatus] 674656864 KJ872588.1 138 2.984e-63 Monochamus alternatus ferritin 2 mRNA, complete cds -- -- -- -- -- -- -- -- PF00210//PF07545//PF07473 Ferritin-like domain//Vestigial/Tondu family//Spasmodic peptide gm9a; conotoxin from Conus species GO:0009405//GO:0006879//GO:0006355 pathogenesis//cellular iron ion homeostasis//regulation of transcription, DNA-templated GO:0008199 ferric iron binding GO:0005634//GO:0005576 nucleus//extracellular region -- -- Cluster-8309.36877 BF_2 153.83 1.72 4025 478251563 ENN72025.1 1955 5.3e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 3.5e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.36879 BF_2 869.96 24.88 1750 270016295 EFA12741.1 1660 3.7e-182 Rm62 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.91074e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1365 2.5e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF03141//PF04851 DEAD/DEAH box helicase//Putative S-adenosyl-L-methionine-dependent methyltransferase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0008168//GO:0003676//GO:0016787//GO:0003677 ATP binding//methyltransferase activity//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.36880 BF_2 375.00 9.31 1973 642918053 XP_008198996.1 1358 4.4e-147 PREDICTED: nucleolar protein 11 [Tribolium castaneum]>gi|270004715|gb|EFA01163.1| hypothetical protein TcasGA2_TC010388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INI5 218 2.8e-16 Nucleolar protein 11 OS=Xenopus laevis GN=nol11 PE=2 SV=2 PF00971//PF01335 EIAV coat protein, gp90//Death effector domain GO:0042981 regulation of apoptotic process GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0019031 viral envelope -- -- Cluster-8309.36881 BF_2 11404.00 609.40 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05180 DNL zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36882 BF_2 676.64 3.40 8617 642931063 XP_008196196.1 1688 1.0e-184 PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|642931065|ref|XP_008196197.1| PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|270011892|gb|EFA08340.1| hypothetical protein TcasGA2_TC005983 [Tribolium castaneum] 195484142 XM_002090535.1 90 3.66186e-36 Drosophila yakuba RpS26 (Dyak\RpS26), partial mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 Q9GT45 503 1.1e-48 40S ribosomal protein S26 OS=Anopheles gambiae GN=RpS26 PE=3 SV=2 PF15473//PF01283 PEST, proteolytic signal-containing nuclear protein family//Ribosomal protein S26e GO:0042254//GO:0016567//GO:0006412 ribosome biogenesis//protein ubiquitination//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1768 40s ribosomal protein S26 Cluster-8309.36884 BF_2 240.17 1.24 8390 642926988 XP_008195092.1 1922 7.4e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 5.79902e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K01320 F7 coagulation factor VII http://www.genome.jp/dbget-bin/www_bget?ko:K01320 P21902 337 1.9e-29 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF02468 Trypsin//Photosystem II reaction centre N protein (psbN) GO:0015979//GO:0006508 photosynthesis//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.36885 BF_2 3889.66 55.12 3239 478254773 ENN75009.1 1721 5.8e-189 hypothetical protein YQE_08326, partial [Dendroctonus ponderosae]>gi|546674398|gb|ERL85785.1| hypothetical protein D910_03200 [Dendroctonus ponderosae] 768418305 XM_011551531.1 267 5.52267e-135 PREDICTED: Plutella xylostella serine/threonine-protein phosphatase alpha-2 isoform (LOC105381736), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q6NVU2 1617 2.7e-178 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Xenopus tropicalis GN=ppp1cc PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.36886 BF_2 53.75 0.42 5686 642935312 XP_008197963.1 2058 8.5e-228 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.15446e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1122 1.2e-120 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF00038//PF10186 Intermediate filament protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy GO:0005198 structural molecule activity GO:0005882 intermediate filament -- -- Cluster-8309.36887 BF_2 72.04 0.80 4070 642936644 XP_008198521.1 850 7.2e-88 PREDICTED: kinesin heavy chain [Tribolium castaneum] -- -- -- -- -- K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 732 1.4e-75 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF17078//PF16519//PF03999//PF07926//PF05384//PF10473//PF07989//PF10186//PF06156//PF04111//PF07851 SWI5-dependent HO expression protein 3//Tetramerisation domain of TRPM//Microtubule associated protein (MAP65/ASE1 family)//TPR/MLP1/MLP2-like protein//Sensor protein DegS//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Vacuolar sorting 38 and autophagy-related subunit 14//Protein of unknown function (DUF972)//Autophagy protein Apg6//TMPIT-like protein GO:0048309//GO:0051028//GO:0000910//GO:0000226//GO:0006914//GO:0007165//GO:0051262//GO:0010508//GO:0006260//GO:0006606 endoplasmic reticulum inheritance//mRNA transport//cytokinesis//microtubule cytoskeleton organization//autophagy//signal transduction//protein tetramerization//positive regulation of autophagy//DNA replication//protein import into nucleus GO:0008017//GO:0042803//GO:0008134//GO:0045502//GO:0016301 microtubule binding//protein homodimerization activity//transcription factor binding//dynein binding//kinase activity GO:0005667//GO:0030286//GO:0045298//GO:0005815//GO:0016021 transcription factor complex//dynein complex//tubulin complex//microtubule organizing center//integral component of membrane KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.36888 BF_2 270.63 3.58 3451 478257812 ENN77955.1 340 8.4e-29 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0042254//GO:0001522//GO:0006464 ribosome biogenesis//pseudouridine synthesis//cellular protein modification process GO:0016151//GO:0030515 nickel cation binding//snoRNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.3689 BF_2 48.42 0.68 3249 546676105 ERL87172.1 1332 7.4e-144 hypothetical protein D910_04572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7K175 535 8.0e-53 Small RNA 2'-O-methyltransferase OS=Drosophila melanogaster GN=Hen1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2 Cluster-8309.36890 BF_2 68.97 1.54 2155 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36891 BF_2 822.77 3.05 11560 642929438 XP_008195840.1 3313 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X1 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 2545 2.4e-285 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00520//PF00312//PF16519//PF12122 Ion transport protein//Ribosomal protein S15//Tetramerisation domain of TRPM//Cytoplasmic N-terminal domain of rhomboid serine protease GO:0051262//GO:0055085//GO:0006412//GO:0042254//GO:0006811 protein tetramerization//transmembrane transport//translation//ribosome biogenesis//ion transport GO:0005216//GO:0003735//GO:0004252 ion channel activity//structural constituent of ribosome//serine-type endopeptidase activity GO:0016021//GO:0005840//GO:0016020//GO:0005622 integral component of membrane//ribosome//membrane//intracellular KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.36892 BF_2 3203.52 42.00 3478 270016569 EFA13015.1 3609 0.0e+00 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] 831318133 XM_012836335.1 35 5.51433e-06 PREDICTED: Clupea harengus low density lipoprotein receptor-related protein 2 (lrp2), mRNA -- -- -- -- P35953 1725 8.8e-191 Very low-density lipoprotein receptor OS=Oryctolagus cuniculus GN=VLDLR PE=2 SV=1 PF00057//PF07645//PF08506//PF00002 Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Cse1//7 transmembrane receptor (Secretin family) GO:0007186//GO:0006886 G-protein coupled receptor signaling pathway//intracellular protein transport GO:0004930//GO:0005509//GO:0005515 G-protein coupled receptor activity//calcium ion binding//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.36893 BF_2 5257.02 22.39 10111 270003787 EFA00235.1 2422 9.4e-270 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 462304009 APGK01049651.1 110 3.27701e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 871 2.7e-91 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF13895//PF00041//PF16656//PF01637//PF08176//PF02899//PF00005//PF03193//PF03931//PF01061//PF07714//PF01926//PF13304//PF00069//PF00621 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Archaeal ATPase//Small acid-soluble spore protein K family//Phage integrase, N-terminal SAM-like domain//ABC transporter//Protein of unknown function, DUF258//Skp1 family, tetramerisation domain//ABC-2 type transporter//Protein tyrosine kinase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein kinase domain//RhoGEF domain GO:0015074//GO:0043087//GO:0006771//GO:0006511//GO:0030436//GO:0019497//GO:0006468//GO:0035023 DNA integration//regulation of GTPase activity//riboflavin metabolic process//ubiquitin-dependent protein catabolic process//asexual sporulation//hexachlorocyclohexane metabolic process//protein phosphorylation//regulation of Rho protein signal transduction GO:0004672//GO:0046872//GO:0005089//GO:0005525//GO:0005515//GO:0003677//GO:0003993//GO:0016887//GO:0003924//GO:0005524 protein kinase activity//metal ion binding//Rho guanyl-nucleotide exchange factor activity//GTP binding//protein binding//DNA binding//acid phosphatase activity//ATPase activity//GTPase activity//ATP binding GO:0016020//GO:0042601 membrane//endospore-forming forespore -- -- Cluster-8309.36894 BF_2 76.80 0.50 6737 642915809 XP_008200087.1 1290 1.1e-138 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 594 2.4e-59 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF01450//PF00501 Acetohydroxy acid isomeroreductase, catalytic domain//AMP-binding enzyme GO:0055114//GO:0009099//GO:0009097//GO:0008152//GO:0009098//GO:0015940//GO:0009082 oxidation-reduction process//valine biosynthetic process//isoleucine biosynthetic process//metabolic process//leucine biosynthetic process//pantothenate biosynthetic process//branched-chain amino acid biosynthetic process GO:0004455//GO:0003824 ketol-acid reductoisomerase activity//catalytic activity -- -- -- -- Cluster-8309.36896 BF_2 29425.73 232.88 5573 642933915 XP_008197565.1 1628 6.0e-178 PREDICTED: calreticulin [Tribolium castaneum]>gi|270013651|gb|EFA10099.1| hypothetical protein TcasGA2_TC012278 [Tribolium castaneum] 332373611 BT126985.1 410 0 Dendroctonus ponderosae clone DPO0910_M08 unknown mRNA K08057 CALR calreticulin http://www.genome.jp/dbget-bin/www_bget?ko:K08057 Q7Z1E6 1398 1.2e-152 Calreticulin OS=Bombyx mori GN=crt PE=1 SV=1 PF00262//PF07127//PF02854 Calreticulin family//Late nodulin protein//MIF4G domain GO:0009878//GO:0006457 nodule morphogenesis//protein folding GO:0005509//GO:0051082//GO:0046872//GO:0003723//GO:0005515 calcium ion binding//unfolded protein binding//metal ion binding//RNA binding//protein binding GO:0005783 endoplasmic reticulum KOG0674 Calreticulin Cluster-8309.36897 BF_2 2224.05 92.77 1290 91085997 XP_972384.1 1187 1.9e-127 PREDICTED: cyclin-related protein FAM58A [Tribolium castaneum]>gi|270010183|gb|EFA06631.1| hypothetical protein TcasGA2_TC009550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4QQW5 520 1.7e-51 Cyclin-related protein FAM58A OS=Rattus norvegicus GN=Fam58a PE=2 SV=1 PF02984 Cyclin, C-terminal domain GO:0006355//GO:0000079 regulation of transcription, DNA-templated//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901 protein kinase binding GO:0005634 nucleus KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.36898 BF_2 2184.61 49.30 2141 546674950 ERL86223.1 2253 7.8e-251 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 8.08832e-112 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1690 6.2e-187 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF00390//PF03949 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain GO:0006090//GO:0006099//GO:0015976//GO:0006108//GO:0055114 pyruvate metabolic process//tricarboxylic acid cycle//carbon utilization//malate metabolic process//oxidation-reduction process GO:0004471//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.36899 BF_2 243.21 0.92 11343 642933491 XP_008197440.1 2917 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 211 2.63023e-103 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1747 8.0e-193 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF01479//PF00163 S4 domain//Ribosomal protein S4/S9 N-terminal domain GO:0008152 metabolic process GO:0003723//GO:0019843//GO:0003824 RNA binding//rRNA binding//catalytic activity GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.369 BF_2 27.00 4.35 547 321477237 EFX88196.1 609 8.6e-61 hypothetical protein DAPPUDRAFT_305566 [Daphnia pulex] 884814334 XM_013129207.1 48 4.87991e-14 PREDICTED: Melopsittacus undulatus ribosomal protein L21 (LOC101874126), transcript variant X3, mRNA K02889 RP-L21e, RPL21 large subunit ribosomal protein L21e http://www.genome.jp/dbget-bin/www_bget?ko:K02889 P46778 558 2.9e-56 60S ribosomal protein L21 OS=Homo sapiens GN=RPL21 PE=1 SV=2 PF01157 Ribosomal protein L21e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.3690 BF_2 3.00 0.31 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36900 BF_2 15.97 0.31 2420 478251082 ENN71558.1 804 9.3e-83 hypothetical protein YQE_11660, partial [Dendroctonus ponderosae]>gi|546671909|gb|ERL84016.1| hypothetical protein D910_01335 [Dendroctonus ponderosae]>gi|546671968|gb|ERL84050.1| hypothetical protein D910_01379 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P04572 289 2.0e-24 Sarcoplasmic calcium-binding protein OS=Perinereis vancaurica tetradentata PE=1 SV=1 PF13833//PF10591//PF00036//PF13405//PF13499//PF12513//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain//EF-hand domain pair//Mitochondrial degradasome RNA helicase subunit C terminal//EF hand GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.36902 BF_2 112.00 8.52 837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.36903 BF_2 288.15 38.28 602 91092830 XP_968086.1 444 1.3e-41 PREDICTED: prefoldin subunit 6 [Tribolium castaneum]>gi|270003070|gb|EEZ99517.1| hypothetical protein TcasGA2_TC000098 [Tribolium castaneum] -- -- -- -- -- K04798 pfdB, PFDN6 prefoldin beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04798 O15212 261 8.7e-22 Prefoldin subunit 6 OS=Homo sapiens GN=PFDN6 PE=1 SV=1 PF09177//PF03938//PF09036//PF02346//PF07195//PF01920//PF12009 Syntaxin 6, N-terminal//Outer membrane protein (OmpH-like)//Bcr-Abl oncoprotein oligomerisation domain//Chordopoxvirus multifunctional envelope protein A27//Flagellar hook-associated protein 2 C-terminus//Prefoldin subunit//Telomerase ribonucleoprotein complex - RNA binding domain GO:0006457//GO:0048193//GO:0019064//GO:0016310//GO:0007155//GO:0007165//GO:0006278//GO:0009069//GO:0006468 protein folding//Golgi vesicle transport//fusion of virus membrane with host plasma membrane//phosphorylation//cell adhesion//signal transduction//RNA-dependent DNA replication//serine family amino acid metabolic process//protein phosphorylation GO:0003964//GO:0005096//GO:0051082//GO:0004674 RNA-directed DNA polymerase activity//GTPase activator activity//unfolded protein binding//protein serine/threonine kinase activity GO:0019031//GO:0016020//GO:0009288//GO:0016272 viral envelope//membrane//bacterial-type flagellum//prefoldin complex KOG3478 Prefoldin subunit 6, KE2 family Cluster-8309.36904 BF_2 5564.77 197.64 1465 332376001 AEE63141.1 1215 1.2e-130 unknown [Dendroctonus ponderosae] 332376000 BT128180.1 70 8.01238e-26 Dendroctonus ponderosae clone DPO1027_P21 unknown mRNA -- -- -- -- Q5BLY5 569 4.1e-57 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.36905 BF_2 896.72 8.87 4514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219//PF03089 Insulin-like growth factor binding protein//Recombination activating protein 2 GO:0001558//GO:0006310 regulation of cell growth//DNA recombination GO:0003677//GO:0005520 DNA binding//insulin-like growth factor binding GO:0016942//GO:0005576//GO:0005634 insulin-like growth factor binding protein complex//extracellular region//nucleus -- -- Cluster-8309.36906 BF_2 650.80 7.98 3700 270016569 EFA13015.1 3331 0.0e+00 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] 831318133 XM_012836335.1 35 5.86999e-06 PREDICTED: Clupea harengus low density lipoprotein receptor-related protein 2 (lrp2), mRNA -- -- -- -- P35953 1649 6.1e-182 Very low-density lipoprotein receptor OS=Oryctolagus cuniculus GN=VLDLR PE=2 SV=1 PF00057//PF07645//PF07095//PF00002//PF06682//PF08506 Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Intracellular growth attenuator protein IgaA//7 transmembrane receptor (Secretin family)//SOCE-associated regulatory factor of calcium homoeostasis//Cse1 GO:0007186//GO:0006886//GO:2001256 G-protein coupled receptor signaling pathway//intracellular protein transport//regulation of store-operated calcium entry GO:0005509//GO:0005515//GO:0004930 calcium ion binding//protein binding//G-protein coupled receptor activity GO:0009276//GO:0016021//GO:0030176 Gram-negative-bacterium-type cell wall//integral component of membrane//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.36907 BF_2 35.37 0.48 3392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36908 BF_2 436.10 16.82 1372 270004078 EFA00526.1 545 5.7e-53 hypothetical protein TcasGA2_TC003391 [Tribolium castaneum] 662204498 XM_008477405.1 35 2.14264e-06 PREDICTED: Diaphorina citri uncharacterized LOC103512635 (LOC103512635), mRNA -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.36909 BF_2 1655.79 8.37 8566 642934041 XP_008197616.1 3918 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B [Tribolium castaneum] 158293303 XM_314669.4 186 1.56677e-89 Anopheles gambiae str. PEST AGAP008559-PA (AgaP_AGAP008559) mRNA, partial cds -- -- -- -- P16157 784 2.8e-81 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF01674//PF00975//PF00023//PF07859//PF00558//PF00520//PF01764//PF13606//PF06821//PF02201 Lipase (class 2)//Thioesterase domain//Ankyrin repeat//alpha/beta hydrolase fold//Vpu protein//Ion transport protein//Lipase (class 3)//Ankyrin repeat//Serine hydrolase//SWIB/MDM2 domain GO:0055085//GO:0008152//GO:0019076//GO:0006629//GO:0006812//GO:0006811//GO:0009058//GO:0032801 transmembrane transport//metabolic process//viral release from host cell//lipid metabolic process//cation transport//ion transport//biosynthetic process//receptor catabolic process GO:0016787//GO:0016788//GO:0005515//GO:0005261//GO:0005216 hydrolase activity//hydrolase activity, acting on ester bonds//protein binding//cation channel activity//ion channel activity GO:0016020//GO:0033644 membrane//host cell membrane KOG4177 Ankyrin Cluster-8309.36910 BF_2 2844.70 14.51 8488 270002790 EEZ99237.1 1342 1.3e-144 held out wings [Tribolium castaneum] 645014013 XM_008207131.1 223 4.19594e-110 PREDICTED: Nasonia vitripennis protein held out wings (LOC100120734), mRNA K14945 QKI protein quaking http://www.genome.jp/dbget-bin/www_bget?ko:K14945 O01367 1015 4.6e-108 Protein held out wings OS=Drosophila melanogaster GN=how PE=1 SV=1 PF13014//PF00013//PF13762 KH domain//KH domain//Mitochondrial splicing apparatus component GO:0000372 Group I intron splicing GO:0003723 RNA binding GO:0030529 intracellular ribonucleoprotein complex KOG1588 RNA-binding protein Sam68 and related KH domain proteins Cluster-8309.36912 BF_2 1175.76 4.88 10358 91090496 XP_969212.1 1701 3.9e-186 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] 642935356 XM_964189.2 200 3.12804e-97 PREDICTED: Tribolium castaneum forkhead box protein P4 (LOC657747), mRNA K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 1044 2.4e-111 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF00250//PF01299//PF01546 Forkhead domain//Lysosome-associated membrane glycoprotein (Lamp)//Peptidase family M20/M25/M40 GO:0006520//GO:0006508//GO:0006355//GO:0000051//GO:0008152 cellular amino acid metabolic process//proteolysis//regulation of transcription, DNA-templated//obsolete urea cycle intermediate metabolic process//metabolic process GO:0003700//GO:0008237//GO:0043565//GO:0004046//GO:0016787 transcription factor activity, sequence-specific DNA binding//metallopeptidase activity//sequence-specific DNA binding//aminoacylase activity//hydrolase activity GO:0005737//GO:0016020//GO:0005667 cytoplasm//membrane//transcription factor complex KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.36914 BF_2 744.00 33.76 1209 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08711 TFIIS helical bundle-like domain GO:0006351 transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.36916 BF_2 31086.30 551.06 2647 642915176 XP_008190506.1 292 2.4e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36919 BF_2 7599.07 97.88 3535 642922924 XP_008200453.1 3883 0.0e+00 PREDICTED: cytoplasmic aconitate hydratase-like [Tribolium castaneum]>gi|270006548|gb|EFA02996.1| hypothetical protein TcasGA2_TC010417 [Tribolium castaneum] 780711820 XM_011706420.1 163 3.9248e-77 PREDICTED: Wasmannia auropunctata cytoplasmic aconitate hydratase-like (LOC105460001), transcript variant X2, mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 P28271 3137 0.0e+00 Cytoplasmic aconitate hydratase OS=Mus musculus GN=Aco1 PE=2 SV=3 PF00694//PF00330 Aconitase C-terminal domain//Aconitase family (aconitate hydratase) GO:0008152 metabolic process GO:0051539 4 iron, 4 sulfur cluster binding -- -- KOG0452 RNA-binding translational regulator IRP (aconitase superfamily) Cluster-8309.36920 BF_2 9726.29 267.18 1810 646714091 KDR18184.1 1655 1.5e-181 Guanine nucleotide-binding protein subunit beta-like protein [Zootermopsis nevadensis] 389610732 AK402355.1 291 1.39444e-148 Papilio polytes mRNA for receptor of activated protein kinase C 1, complete cds, sequence id: Pp-0111 K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1518 4.6e-167 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.36921 BF_2 82.87 0.52 6926 91089043 XP_969794.1 2493 3.7e-278 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.55224e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 1895 3.4e-210 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.36922 BF_2 127.39 1.16 4875 478254062 ENN74354.1 272 9.1e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36923 BF_2 58.45 0.83 3233 642912940 XP_008201316.1 816 5.0e-84 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5MGH0 543 9.4e-54 Serine protease inhibitor 3/4 (Fragment) OS=Lonomia obliqua PE=1 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.36924 BF_2 1896.22 14.17 5886 642933803 XP_008197345.1 467 2.7e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 1.11369e-64 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36926 BF_2 3085.34 347.09 659 332373744 AEE62013.1 180 5.7e-11 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36927 BF_2 389.98 1.44 11612 270002882 EEZ99329.1 2111 1.2e-233 hu li tai shao [Tribolium castaneum] 642912486 XM_008202663.1 133 6.16832e-60 PREDICTED: Tribolium castaneum protein hu-li tai shao (LOC659560), transcript variant X3, mRNA K18622 ADD adducin http://www.genome.jp/dbget-bin/www_bget?ko:K18622 Q02645 1443 1.5e-157 Protein hu-li tai shao OS=Drosophila melanogaster GN=hts PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3699 Cytoskeletal protein Adducin Cluster-8309.36928 BF_2 185.11 2.03 4097 91084075 XP_967986.1 1341 8.5e-145 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I923 524 1.9e-51 Regucalcin OS=Gallus gallus GN=RGN PE=2 SV=1 -- -- GO:0050790 regulation of catalytic activity GO:0005509//GO:0030234 calcium ion binding//enzyme regulator activity -- -- -- -- Cluster-8309.36929 BF_2 466.43 7.98 2731 642926449 XP_008191964.1 1143 5.1e-122 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|642926451|ref|XP_008191965.1| PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009087|gb|EFA05535.1| hypothetical protein TcasGA2_TC015722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 538 3.0e-53 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF07992//PF05834//PF01266//PF05199//PF02254 GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//potassium ion transport GO:0050660//GO:0016705//GO:0016614//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity -- -- -- -- Cluster-8309.36931 BF_2 2382.52 18.26 5746 827549501 XP_012546855.1 643 1.0e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.6e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.36934 BF_2 580.79 22.82 1352 91078888 XP_973143.1 1435 3.5e-156 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 [Tribolium castaneum]>gi|270003704|gb|EFA00152.1| hypothetical protein TcasGA2_TC002973 [Tribolium castaneum] -- -- -- -- -- K06276 PDPK1 3-phosphoinositide dependent protein kinase-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06276 Q9Z2A0 961 1.3e-102 3-phosphoinositide-dependent protein kinase 1 OS=Mus musculus GN=Pdpk1 PE=1 SV=2 PF07714//PF00069//PF06293//PF05445 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Poxvirus serine/threonine protein kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0592 3-phosphoinositide-dependent protein kinase (PDK1) Cluster-8309.36936 BF_2 80.22 1.04 3522 73921486 AAZ94273.1 2265 5.2e-252 cytochrome P450 [Leptinotarsa decemlineata] 73921485 DQ117464.1 403 0 Leptinotarsa decemlineata cytochrome P450 (CYP4G29) mRNA, complete cds K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 Q9VYY4 1777 8.3e-197 Cytochrome P450 4g15 OS=Drosophila melanogaster GN=Cyp4g15 PE=2 SV=1 PF00067//PF00762 Cytochrome P450//Ferrochelatase GO:0015994//GO:0055114//GO:0006783 chlorophyll metabolic process//oxidation-reduction process//heme biosynthetic process GO:0005506//GO:0020037//GO:0016705//GO:0004325 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ferrochelatase activity -- -- -- -- Cluster-8309.36937 BF_2 5651.52 61.36 4140 189236215 XP_975776.2 3673 0.0e+00 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 7.0762e-135 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 987 3.9e-105 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.36938 BF_2 333.28 22.42 909 255522807 NP_001157316.1 714 9.5e-73 longitudinals lacking isoform 7 [Tribolium castaneum] 255522808 NM_001163845.1 255 7.07353e-129 Tribolium castaneum longitudinals lacking (Lola), transcript variant 8, mRNA -- -- -- -- -- -- -- -- PF00096//PF13465//PF04988 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.36940 BF_2 3436.89 41.28 3770 148230813 NP_001083770.1 359 5.8e-31 microtubule-associated protein 4 [Xenopus laevis]>gi|4063005|dbj|BAA36221.1| XMAP4 [Xenopus laevis] -- -- -- -- -- -- -- -- -- P12036 213 2.0e-15 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF02730 Aldehyde ferredoxin oxidoreductase, N-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0016625//GO:0051536 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor//iron-sulfur cluster binding -- -- -- -- Cluster-8309.36941 BF_2 600.77 11.09 2554 546684136 ERL93841.1 993 1.2e-104 hypothetical protein D910_11127, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12592 Protein of unknown function (DUF3763) -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- -- -- Cluster-8309.36942 BF_2 7692.03 1109.98 577 91090912 XP_973979.1 703 1.1e-71 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] 642936036 XM_968886.2 165 4.71143e-79 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P47948 618 3.4e-63 Troponin C, isoform 2 OS=Drosophila melanogaster GN=TpnC47D PE=2 SV=2 PF03528//PF13833//PF13405//PF00036//PF13499//PF13202//PF12763 Rabaptin//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005515//GO:0005509//GO:0005096//GO:0008083 protein binding//calcium ion binding//GTPase activator activity//growth factor activity -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.36945 BF_2 485.01 15.54 1593 91076140 XP_970221.1 1054 6.3e-112 PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|642911692|ref|XP_008200703.1| PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|642911694|ref|XP_008200704.1| PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|642911696|ref|XP_008200705.1| PREDICTED: adapter molecule Crk [Tribolium castaneum]>gi|270014714|gb|EFA11162.1| hypothetical protein TcasGA2_TC004767 [Tribolium castaneum] -- -- -- -- -- K04438 CRK, CRKII proto-oncogene C-crk http://www.genome.jp/dbget-bin/www_bget?ko:K04438 Q9XYM0 845 4.4e-89 Adapter molecule Crk OS=Drosophila melanogaster GN=Crk PE=1 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4792 Crk family adapters Cluster-8309.36946 BF_2 2820.54 25.60 4897 642933803 XP_008197345.1 467 2.2e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 9.25406e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q5KSL6 146 1.5e-07 Diacylglycerol kinase kappa OS=Homo sapiens GN=DGKK PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36947 BF_2 529.71 2.92 7865 642929711 XP_008195945.1 2542 8.8e-284 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X1 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.67276e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q60996 1954 5.5e-217 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform OS=Mus musculus GN=Ppp2r5c PE=1 SV=2 PF06068//PF05496//PF01603//PF07728//PF01695//PF07724//PF00004 TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0007165//GO:0006281 DNA recombination//signal transduction//DNA repair GO:0016887//GO:0009378//GO:0008601//GO:0005524//GO:0003678 ATPase activity//four-way junction helicase activity//protein phosphatase type 2A regulator activity//ATP binding//DNA helicase activity GO:0000159//GO:0009379//GO:0005657 protein phosphatase type 2A complex//Holliday junction helicase complex//replication fork KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.36948 BF_2 232.53 1.51 6715 642926249 XP_974073.3 1630 4.3e-178 PREDICTED: mannose-1-phosphate guanyltransferase beta [Tribolium castaneum]>gi|270009027|gb|EFA05475.1| hypothetical protein TcasGA2_TC015659 [Tribolium castaneum] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q295Y7 1534 2.4e-168 Mannose-1-phosphate guanyltransferase beta OS=Drosophila pseudoobscura pseudoobscura GN=GA10892 PE=3 SV=1 PF06459//PF09726//PF00076//PF07959//PF01128//PF09270//PF04111//PF00483//PF08671//PF02932 Ryanodine Receptor TM 4-6//Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//L-fucokinase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//Beta-trefoil DNA-binding domain//Autophagy protein Apg6//Nucleotidyl transferase//Anti-repressor SinI//Neurotransmitter-gated ion-channel transmembrane region GO:0006914//GO:0008299//GO:0006816//GO:0006694//GO:0006874//GO:0009058//GO:0006355//GO:0006811 autophagy//isoprenoid biosynthetic process//calcium ion transport//steroid biosynthetic process//cellular calcium ion homeostasis//biosynthetic process//regulation of transcription, DNA-templated//ion transport GO:0000978//GO:0016779//GO:0050518//GO:0016772//GO:0000982//GO:0046983//GO:0005219//GO:0003676 RNA polymerase II core promoter proximal region sequence-specific DNA binding//nucleotidyltransferase activity//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//transferase activity, transferring phosphorus-containing groups//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//protein dimerization activity//ryanodine-sensitive calcium-release channel activity//nucleic acid binding GO:0016021//GO:0005622//GO:0005634//GO:0016020 integral component of membrane//intracellular//nucleus//membrane KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.36949 BF_2 18157.00 986.64 1057 91089051 XP_970069.1 1019 4.7e-108 PREDICTED: 40S ribosomal protein SA [Tribolium castaneum]>gi|270012401|gb|EFA08849.1| hypothetical protein TcasGA2_TC006550 [Tribolium castaneum] -- -- -- -- -- K02998 RP-SAe, RPSA small subunit ribosomal protein SAe http://www.genome.jp/dbget-bin/www_bget?ko:K02998 Q5UAP4 925 1.5e-98 40S ribosomal protein SA OS=Bombyx mori PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0015935//GO:0005840 intracellular//small ribosomal subunit//ribosome -- -- Cluster-8309.36950 BF_2 2991.55 26.14 5074 478250592 ENN71084.1 1150 1.5e-122 hypothetical protein YQE_12017, partial [Dendroctonus ponderosae]>gi|546672947|gb|ERL84655.1| hypothetical protein D910_02082 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GLM5 222 2.5e-16 Desumoylating isopeptidase 1 OS=Xenopus laevis GN=desi1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.36951 BF_2 216.39 1.17 8052 507228 AAA64736.1 584 1.0e-56 apolipophorin-III, partial [Derobrachus geminatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08702//PF04513//PF02601//PF09392//PF04799//PF14942//PF06109//PF10150//PF01474//PF01601//PF02993//PF07851//PF05531//PF06008//PF05478//PF01442//PF07464//PF16716//PF00804//PF05823 Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//fzo-like conserved region//Organelle biogenesis, Muted-like protein//Haemolysin E (HlyE)//Ribonuclease E/G family//Class-II DAHP synthetase family//Coronavirus S2 glycoprotein//Minor capsid protein VI//TMPIT-like protein//Nucleopolyhedrovirus P10 protein//Laminin Domain I//Prominin//Apolipoprotein A1/A4/E domain//Apolipophorin-III precursor (apoLp-III)//Bone marrow stromal antigen 2//Syntaxin//Nematode fatty acid retinoid binding protein (Gp-FAR-1) GO:0006308//GO:0046813//GO:0061025//GO:0030155//GO:0009094//GO:0051607//GO:0006869//GO:0042157//GO:0015031//GO:0051258//GO:0044179//GO:0030334//GO:0009405//GO:0007165//GO:0000162//GO:0009073//GO:0030168//GO:0008053//GO:0045995//GO:0006571 DNA catabolic process//receptor-mediated virion attachment to host cell//membrane fusion//regulation of cell adhesion//L-phenylalanine biosynthetic process//defense response to virus//lipid transport//lipoprotein metabolic process//protein transport//protein polymerization//hemolysis in other organism//regulation of cell migration//pathogenesis//signal transduction//tryptophan biosynthetic process//aromatic amino acid family biosynthetic process//platelet activation//mitochondrial fusion//regulation of embryonic development//tyrosine biosynthetic process GO:0008855//GO:0003723//GO:0003849//GO:0005198//GO:0030674//GO:0008289//GO:0005102//GO:0003924 exodeoxyribonuclease VII activity//RNA binding//3-deoxy-7-phosphoheptulonate synthase activity//structural molecule activity//protein binding, bridging//lipid binding//receptor binding//GTPase activity GO:0030133//GO:0016020//GO:0005576//GO:0005741//GO:0019031//GO:0016021//GO:0031083//GO:0005577//GO:0009318//GO:0019028 transport vesicle//membrane//extracellular region//mitochondrial outer membrane//viral envelope//integral component of membrane//BLOC-1 complex//fibrinogen complex//exodeoxyribonuclease VII complex//viral capsid -- -- Cluster-8309.36952 BF_2 278.17 3.08 4060 189240877 XP_971050.2 976 1.8e-102 PREDICTED: leucine-rich repeat flightless-interacting protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9W6 441 7.9e-42 Leucine-rich repeat flightless-interacting protein 2 OS=Bos taurus GN=LRRFIP2 PE=2 SV=1 PF00769//PF05557 Ezrin/radixin/moesin family//Mitotic checkpoint protein GO:0007094 mitotic spindle assembly checkpoint GO:0008092 cytoskeletal protein binding GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2010 Double stranded RNA binding protein Cluster-8309.36953 BF_2 19.64 0.66 1523 642912701 XP_970424.2 1272 3.2e-137 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q7XJS0 445 1.0e-42 Histone-lysine N-methyltransferase ASHR1 OS=Arabidopsis thaliana GN=ASHR1 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.36954 BF_2 356.40 2.82 5572 546672885 ERL84608.1 3008 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1606 8.8e-177 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00975//PF00106//PF00107 Thioesterase domain//short chain dehydrogenase//Zinc-binding dehydrogenase GO:0008152//GO:0009058//GO:0055114 metabolic process//biosynthetic process//oxidation-reduction process GO:0016788//GO:0016491 hydrolase activity, acting on ester bonds//oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.36955 BF_2 452.78 11.75 1899 642934430 XP_008197659.1 2383 5.8e-266 PREDICTED: mitochondrial Rho GTPase isoform X1 [Tribolium castaneum] -- -- -- -- -- K07870 RHOT1, ARHT1 Ras homolog gene family, member T1 http://www.genome.jp/dbget-bin/www_bget?ko:K07870 Q8IMX7 1696 1.1e-187 Mitochondrial Rho GTPase OS=Drosophila melanogaster GN=Miro PE=1 SV=1 PF07231//PF00005//PF03193//PF00910//PF04670//PF10662//PF00071//PF02367//PF00036//PF13202//PF07475//PF01926//PF13499//PF01695//PF08477//PF00735//PF13405//PF07728//PF00025//PF00004 Hs1pro-1 N-terminus//ABC transporter//Protein of unknown function, DUF258//RNA helicase//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//EF hand//EF hand//HPr Serine kinase C-terminal domain//50S ribosome-binding GTPase//EF-hand domain pair//IstB-like ATP binding protein//Ras of Complex, Roc, domain of DAPkinase//Septin//EF-hand domain//AAA domain (dynein-related subfamily)//ADP-ribosylation factor family//ATPase family associated with various cellular activities (AAA) GO:0002949//GO:0007264//GO:0006576//GO:0016310//GO:0000160//GO:0006109//GO:0006952 tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction//cellular biogenic amine metabolic process//phosphorylation//phosphorelay signal transduction system//regulation of carbohydrate metabolic process//defense response GO:0005525//GO:0005509//GO:0003724//GO:0004672//GO:0003723//GO:0016887//GO:0005524//GO:0000155//GO:0003924 GTP binding//calcium ion binding//RNA helicase activity//protein kinase activity//RNA binding//ATPase activity//ATP binding//phosphorelay sensor kinase activity//GTPase activity GO:0009365 protein histidine kinase complex KOG1707 Predicted Ras related/Rac-GTP binding protein Cluster-8309.36957 BF_2 130.76 0.85 6694 642911053 XP_008200620.1 8548 0.0e+00 PREDICTED: HEAT repeat-containing protein 5B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2D3 5379 0.0e+00 HEAT repeat-containing protein 5B OS=Homo sapiens GN=HEATR5B PE=1 SV=2 PF00514//PF08785//PF02985 Armadillo/beta-catenin-like repeat//Ku C terminal domain like//HEAT repeat -- -- GO:0005515//GO:0016817 protein binding//hydrolase activity, acting on acid anhydrides -- -- KOG1822 Uncharacterized conserved protein Cluster-8309.36958 BF_2 533.04 3.65 6400 642928644 XP_008199718.1 1825 1.0e-200 PREDICTED: oxysterol-binding protein-related protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZF3 1247 4.3e-135 Oxysterol-binding protein-related protein 6 OS=Homo sapiens GN=OSBPL6 PE=1 SV=1 PF03623 Focal adhesion targeting region GO:0007165//GO:0007172//GO:0006468 signal transduction//signal complex assembly//protein phosphorylation GO:0004871//GO:0004713 signal transducer activity//protein tyrosine kinase activity GO:0005925 focal adhesion -- -- Cluster-8309.36959 BF_2 423.64 1.80 10149 642934181 XP_008199641.1 2782 0.0e+00 PREDICTED: uncharacterized protein LOC657682 isoform X2 [Tribolium castaneum] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 1.8e-215 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF00130//PF04857//PF10510//PF17095//PF00183//PF00628//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//CAF1 family ribonuclease//Phosphatidylinositol-glycan biosynthesis class S protein//Spectrin-binding region of Ca2+-Calmodulin//Hsp90 protein//PHD-finger//C1-like domain GO:0031175//GO:0035556//GO:0055114//GO:0006457//GO:0006950//GO:0016255 neuron projection development//intracellular signal transduction//oxidation-reduction process//protein folding//response to stress//attachment of GPI anchor to protein GO:0051082//GO:0047134//GO:0030507//GO:0005524//GO:0005516//GO:0005515 unfolded protein binding//protein-disulfide reductase activity//spectrin binding//ATP binding//calmodulin binding//protein binding GO:0008091//GO:0042765//GO:0005634 spectrin//GPI-anchor transamidase complex//nucleus KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.36960 BF_2 597.00 21.76 1435 642938161 XP_968707.2 769 6.3e-79 PREDICTED: ras-related and estrogen-regulated growth inhibitor-like protein [Tribolium castaneum]>gi|270016488|gb|EFA12934.1| hypothetical protein TcasGA2_TC010480 [Tribolium castaneum] -- -- -- -- -- K07855 RERG Ras-related and estrogen-regulated growth inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K07855 Q0VCJ7 299 8.2e-26 Ras-related and estrogen-regulated growth inhibitor OS=Bos taurus GN=RERG PE=2 SV=1 PF00071//PF14525//PF04218//PF01926//PF08477//PF03193 Ras family//AraC-binding-like domain//CENP-B N-terminal DNA-binding domain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0006355//GO:0006184//GO:0007264 regulation of transcription, DNA-templated//obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005525//GO:0003677//GO:0003924 GTP binding//DNA binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.36962 BF_2 56.44 0.44 5617 332375705 AEE62993.1 1349 1.4e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01619 deoC, DERA deoxyribose-phosphate aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01619 Q9Y315 963 3.2e-102 Deoxyribose-phosphate aldolase OS=Homo sapiens GN=DERA PE=1 SV=2 PF00096//PF01791//PF00651 Zinc finger, C2H2 type//DeoC/LacD family aldolase//BTB/POZ domain -- -- GO:0016829//GO:0005515//GO:0046872 lyase activity//protein binding//metal ion binding -- -- KOG3981 Deoxyribose-phosphate aldolase Cluster-8309.36963 BF_2 663.26 6.17 4785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36964 BF_2 361.06 16.16 1222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01177 Asp/Glu/Hydantoin racemase GO:0006807 nitrogen compound metabolic process GO:0036361 racemase activity, acting on amino acids and derivatives -- -- -- -- Cluster-8309.36966 BF_2 731.92 15.78 2228 642932594 XP_967443.2 1634 4.9e-179 PREDICTED: fatty-acid amide hydrolase 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6GMR7 833 1.5e-87 Fatty-acid amide hydrolase 2 OS=Homo sapiens GN=FAAH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.36968 BF_2 1355.11 21.76 2892 642911373 XP_008199397.1 433 1.2e-39 PREDICTED: syndecan [Tribolium castaneum] -- -- -- -- -- K16336 SDC2 syndecan 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16336 P49415 290 1.8e-24 Syndecan OS=Drosophila melanogaster GN=Sdc PE=2 SV=2 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.36970 BF_2 407.35 16.02 1351 91078140 XP_973588.1 508 1.1e-48 PREDICTED: uncharacterized protein LOC662397 [Tribolium castaneum]>gi|270002341|gb|EEZ98788.1| hypothetical protein TcasGA2_TC001352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.36971 BF_2 134.00 5.36 1333 642920981 XP_008192639.1 1121 8.9e-120 PREDICTED: LOW QUALITY PROTEIN: transforming growth factor beta regulator 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3YBR2 524 6.2e-52 Transforming growth factor beta regulator 1 OS=Homo sapiens GN=TBRG1 PE=1 SV=1 PF00909//PF05965//PF05964 Ammonium Transporter Family//F/Y rich C-terminus//F/Y-rich N-terminus GO:0015696 ammonium transport GO:0008519 ammonium transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.36972 BF_2 14626.27 69.59 9079 557798908 AHA36969.1 2603 8.6e-291 heat shock protein 70b [Leptinotarsa decemlineata] 557798907 KC544269.1 729 0 Leptinotarsa decemlineata heat shock protein 70b mRNA, complete cds K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 P29844 2503 1.4e-280 Heat shock 70 kDa protein cognate 3 OS=Drosophila melanogaster GN=Hsc70-3 PE=2 SV=2 PF00400//PF01968//PF02782//PF06723 WD domain, G-beta repeat//Hydantoinase/oxoprolinase//FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein GO:0005975//GO:0000902 carbohydrate metabolic process//cell morphogenesis GO:0005515//GO:0016787//GO:0016773 protein binding//hydrolase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-8309.36974 BF_2 174.68 1.33 5783 91090858 XP_967143.1 942 2.2e-98 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] 688710729 LL320824.1 36 2.55992e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 722 2.9e-74 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF04851//PF02562//PF00580//PF06733//PF00191//PF01580//PF00270 Type III restriction enzyme, res subunit//PhoH-like protein//UvrD/REP helicase N-terminal domain//DEAD_2//Annexin//FtsK/SpoIIIE family//DEAD/DEAH box helicase -- -- GO:0016787//GO:0003677//GO:0005524//GO:0005544//GO:0004003//GO:0003676//GO:0005509//GO:0000166 hydrolase activity//DNA binding//ATP binding//calcium-dependent phospholipid binding//ATP-dependent DNA helicase activity//nucleic acid binding//calcium ion binding//nucleotide binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.36975 BF_2 71.11 0.81 3954 642921063 XP_008192676.1 518 2.2e-49 PREDICTED: LIM domain transcription factor LMO4.2-like isoform X1 [Tribolium castaneum] 642921066 XM_008194456.1 283 8.616e-144 PREDICTED: Tribolium castaneum LIM domain only protein 3-like (LOC663863), transcript variant X3, mRNA -- -- -- -- Q99MB5 396 1.3e-36 LIM domain only protein 3 OS=Rattus norvegicus GN=Lmo3 PE=2 SV=2 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.36976 BF_2 1777.87 24.16 3366 642933145 XP_008197275.1 2062 1.7e-228 PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum]>gi|642933147|ref|XP_008197277.1| PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum] 642933146 XM_008199055.1 284 2.03605e-144 PREDICTED: Tribolium castaneum extracellular serine/threonine protein kinase FAM20C (LOC662687), transcript variant X2, mRNA -- -- -- -- A4VCL2 1487 3.4e-163 Extracellular serine/threonine protein CG31145 OS=Drosophila melanogaster GN=CG31145 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.36979 BF_2 27665.32 303.29 4103 642910240 XP_008198519.1 1641 1.4e-179 PREDICTED: glycogenin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 P13280 927 3.5e-98 Glycogenin-1 OS=Oryctolagus cuniculus GN=GYG1 PE=1 SV=3 PF01501//PF11051//PF08988 Glycosyl transferase family 8//Mannosyltransferase putative//Type III secretion system, cytoplasmic E component of needle GO:0009405//GO:0006486 pathogenesis//protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.36980 BF_2 22.28 0.41 2583 478262445 ENN81116.1 688 2.8e-69 hypothetical protein YQE_02484, partial [Dendroctonus ponderosae]>gi|546673666|gb|ERL85230.1| hypothetical protein D910_02651 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q08C69 422 8.0e-40 RNA pseudouridylate synthase domain-containing protein 1 OS=Danio rerio GN=rpusd1 PE=2 SV=1 PF00849 RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG1919 RNA pseudouridylate synthases Cluster-8309.36981 BF_2 3857.70 71.73 2537 91086995 XP_973636.1 1879 2.2e-207 PREDICTED: protein krasavietz [Tribolium castaneum] 642929327 XM_968543.2 536 0 PREDICTED: Tribolium castaneum protein krasavietz (LOC662449), mRNA -- -- -- -- Q9VNE2 1321 4.5e-144 Protein krasavietz OS=Drosophila melanogaster GN=kra PE=1 SV=1 PF02020 eIF4-gamma/eIF5/eIF2-epsilon -- -- GO:0005515 protein binding -- -- KOG2297 Predicted translation factor, contains W2 domain Cluster-8309.36982 BF_2 945.11 24.14 1925 478253032 ENN73412.1 234 9.2e-17 hypothetical protein YQE_09974, partial [Dendroctonus ponderosae] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q965X6 208 3.9e-15 E3 ubiquitin-protein ligase siah-1 OS=Caenorhabditis elegans GN=siah-1 PE=1 SV=3 PF15965//PF05195//PF02176//PF03145 TRAF-like zinc-finger//Aminopeptidase P, N-terminal domain//TRAF-type zinc finger//Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0004177//GO:0008270//GO:0030145 aminopeptidase activity//zinc ion binding//manganese ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.36983 BF_2 44.75 1.07 2042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36985 BF_2 132.71 3.78 1755 91080645 XP_974525.1 1505 3.5e-164 PREDICTED: KIF1-binding protein homolog [Tribolium castaneum]>gi|270005501|gb|EFA01949.1| hypothetical protein TcasGA2_TC007564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZIL9 739 9.5e-77 KIF1-binding protein homolog OS=Gallus gallus GN=kbp PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.36986 BF_2 12217.72 232.65 2484 478263722 ENN82025.1 960 7.7e-101 hypothetical protein YQE_01600, partial [Dendroctonus ponderosae] 769857176 XM_011641913.1 177 4.53359e-85 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S23 (LOC105429139), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q6EV23 747 1.6e-77 40S ribosomal protein S23 OS=Papilio dardanus GN=RpS23 PE=2 SV=1 PF09445//PF00164 RNA cap guanine-N2 methyltransferase//Ribosomal protein S12/S23 GO:0009452//GO:0001510//GO:0006412//GO:0042254 7-methylguanosine RNA capping//RNA methylation//translation//ribosome biogenesis GO:0003735//GO:0008168 structural constituent of ribosome//methyltransferase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1749 40S ribosomal protein S23 Cluster-8309.36987 BF_2 6243.93 88.67 3233 288899098 ADC67081.1 2704 6.0e-303 proline dehydrogenase isoform 1 [Leptinotarsa decemlineata] 170047825 XM_001851357.1 257 1.99666e-129 Culex quinquefasciatus proline oxidase, mRNA K00318 PRODH proline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00318 Q04499 2131 6.8e-238 Proline dehydrogenase 1, mitochondrial OS=Drosophila melanogaster GN=slgA PE=1 SV=2 PF05139 Erythromycin esterase GO:0046677 response to antibiotic -- -- -- -- KOG0186 Proline oxidase Cluster-8309.36988 BF_2 1081.38 9.06 5281 642923500 XP_008193535.1 431 3.6e-39 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.36990 BF_2 65.86 1.19 2596 642938577 XP_008199848.1 2080 1.1e-230 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938579|ref|XP_008199849.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938581|ref|XP_008199850.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938583|ref|XP_008199851.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938585|ref|XP_008199852.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|270015602|gb|EFA12050.1| hypothetical protein TcasGA2_TC001467 [Tribolium castaneum] 642938584 XM_008201630.1 540 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X5, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 Q16720 1398 5.4e-153 Plasma membrane calcium-transporting ATPase 3 OS=Homo sapiens GN=ATP2B3 PE=1 SV=3 PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006754//GO:0006816//GO:0070588 ATP biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0005388//GO:0046872//GO:0005524 calcium-transporting ATPase activity//metal ion binding//ATP binding GO:0016529//GO:0016021 sarcoplasmic reticulum//integral component of membrane KOG0204 Calcium transporting ATPase Cluster-8309.36995 BF_2 1899.03 36.21 2481 91078870 XP_972519.1 2161 4.2e-240 PREDICTED: peptide transporter family 1-like [Tribolium castaneum] 462304202 APGK01049574.1 91 2.90433e-37 Dendroctonus ponderosae Seq01049584, whole genome shotgun sequence K14206 SLC15A1, PEPT1 solute carrier family 15 (oligopeptide transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14206 P91679 1396 8.8e-153 Peptide transporter family 1 OS=Drosophila melanogaster GN=yin PE=1 SV=2 PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG1237 H+/oligopeptide symporter Cluster-8309.36999 BF_2 76.76 2.20 1746 749750480 XP_011137500.1 342 2.5e-29 PREDICTED: myosin light chain alkali isoform X1 [Harpegnathos saltator] -- -- -- -- -- K12750 MYL4 myosin light chain 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12750 Q24654 311 4.0e-27 Myosin light chain alkali OS=Drosophila simulans GN=Mlc1 PE=3 SV=3 PF13499//PF13405 EF-hand domain pair//EF-hand domain -- -- GO:0005509 calcium ion binding -- -- KOG0030 Myosin essential light chain, EF-Hand protein superfamily Cluster-8309.37001 BF_2 33.61 0.77 2120 189237983 XP_001814292.1 704 3.2e-71 PREDICTED: filaggrin-2 [Tribolium castaneum]>gi|270006655|gb|EFA03103.1| hypothetical protein TcasGA2_TC013013 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82120 156 4.6e-09 Cuticle protein 7 OS=Blaberus craniifer PE=1 SV=1 -- -- -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.37002 BF_2 361.89 3.63 4457 642933803 XP_008197345.1 467 2.0e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 8.41641e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q9CZG3 131 7.7e-06 COMM domain-containing protein 8 OS=Mus musculus GN=Commd8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37003 BF_2 518.41 11.74 2135 270006980 EFA03428.1 2188 2.7e-243 hypothetical protein TcasGA2_TC013417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFY8 790 1.4e-82 Tripartite motif-containing protein 45 OS=Mus musculus GN=Trim45 PE=2 SV=2 PF00643//PF14634//PF00097//PF13639 B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005622 intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37004 BF_2 3623.51 182.22 1119 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37006 BF_2 115.38 8.06 886 546683852 ERL93605.1 545 3.6e-53 hypothetical protein D910_10893 [Dendroctonus ponderosae] -- -- -- -- -- K02956 RP-S15, MRPS15, rpsO small subunit ribosomal protein S15 http://www.genome.jp/dbget-bin/www_bget?ko:K02956 Q8WTC1 479 6.8e-47 28S ribosomal protein S15, mitochondrial OS=Drosophila melanogaster GN=bonsai PE=2 SV=2 PF02881//PF05531 SRP54-type protein, helical bundle domain//Nucleopolyhedrovirus P10 protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525 GTP binding GO:0019028 viral capsid -- -- Cluster-8309.37007 BF_2 405.85 1.63 10721 242018392 XP_002429661.1 599 2.4e-58 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9EQB9 575 6.1e-57 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF00096//PF01155//PF12937//PF13465//PF09174//PF04810//PF00412//PF13912//PF01363//PF14972//PF00646//PF16622//PF00320 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//F-box-like//Zinc-finger double domain//Maf1 regulator//Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//FYVE zinc finger//Mitochondrial morphogenesis regulator//F-box domain//zinc-finger C2H2-type//GATA zinc finger GO:0006886//GO:0016480//GO:0006888//GO:0006464//GO:0007005//GO:0006355 intracellular protein transport//negative regulation of transcription from RNA polymerase III promoter//ER to Golgi vesicle-mediated transport//cellular protein modification process//mitochondrion organization//regulation of transcription, DNA-templated GO:0016151//GO:0005515//GO:0003700//GO:0046872//GO:0008270//GO:0043565 nickel cation binding//protein binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0031305//GO:0030127 transcription factor complex//integral component of mitochondrial inner membrane//COPII vesicle coat -- -- Cluster-8309.37009 BF_2 2335.00 39.94 2733 727098906 AIY54297.1 1092 4.2e-116 beta-tubulin C [Colaphellus bowringi] 389610986 AK402482.1 52 1.5322e-15 Papilio polytes mRNA for conserved hypothetical protein, complete cds, sequence id: Pp-0317 -- -- -- -- Q3SZE9 536 5.1e-53 Tubulin-specific chaperone C OS=Bos taurus GN=TBCC PE=2 SV=1 PF04718//PF00377//PF16752 Mitochondrial ATP synthase g subunit//Prion/Doppel alpha-helical domain//Tubulin-specific chaperone C N-terminal domain GO:0051260//GO:0015986//GO:0015992 protein homooligomerization//ATP synthesis coupled proton transport//proton transport GO:0015631//GO:0015078 tubulin binding//hydrogen ion transmembrane transporter activity GO:0045298//GO:0016020//GO:0000276 tubulin complex//membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG2512 Beta-tubulin folding cofactor C Cluster-8309.37010 BF_2 12976.34 201.06 2987 642911657 XP_001810552.2 2387 3.2e-266 PREDICTED: double-stranded RNA-binding protein Staufen homolog 2 isoform X3 [Tribolium castaneum] 642911656 XM_001810500.2 174 2.54084e-83 PREDICTED: Tribolium castaneum staufen (LOC657623), transcript variant X3, mRNA K17597 STAU double-stranded RNA-binding protein Staufen http://www.genome.jp/dbget-bin/www_bget?ko:K17597 Q7ZW47 792 1.2e-82 Double-stranded RNA-binding protein Staufen homolog 2 OS=Danio rerio GN=stau2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3732 Staufen and related double-stranded-RNA-binding proteins Cluster-8309.37012 BF_2 784.83 16.52 2275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37014 BF_2 93.73 3.02 1587 546686197 ERL95577.1 364 6.4e-32 hypothetical protein D910_12838 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08586 RSC complex, Rsc14/Ldb7 subunit GO:0043044 ATP-dependent chromatin remodeling -- -- GO:0016586 RSC complex -- -- Cluster-8309.37015 BF_2 9.37 0.46 1130 91086561 XP_975997.1 378 1.1e-33 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X1 [Tribolium castaneum]>gi|270009775|gb|EFA06223.1| hypothetical protein TcasGA2_TC009072 [Tribolium castaneum] -- -- -- -- -- K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 233 2.9e-18 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094//GO:0006099 gluconeogenesis//tricarboxylic acid cycle GO:0004611//GO:0004613//GO:0005525 phosphoenolpyruvate carboxykinase activity//phosphoenolpyruvate carboxykinase (GTP) activity//GTP binding -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37018 BF_2 1012.48 12.79 3599 91085875 XP_966911.1 1172 2.9e-125 PREDICTED: pentatricopeptide repeat-containing protein 2, mitochondrial-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ55 357 3.9e-32 Pentatricopeptide repeat-containing protein 2, mitochondrial OS=Bos taurus GN=PTCD2 PE=2 SV=1 PF11380//PF04750//PF05049 Stealth protein CR2, conserved region 2//FAR-17a/AIG1-like protein//Interferon-inducible GTPase (IIGP) -- -- GO:0005525//GO:0016772 GTP binding//transferase activity, transferring phosphorus-containing groups GO:0016020//GO:0016021 membrane//integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.37019 BF_2 9.68 0.31 1593 478258498 ENN78573.1 152 2.4e-07 hypothetical protein YQE_04941, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37020 BF_2 54.98 26.31 372 332374310 AEE62296.1 180 3.2e-11 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37021 BF_2 4800.67 61.66 3544 189236215 XP_975776.2 3726 0.0e+00 PREDICTED: alpha,alpha-trehalose-phosphate synthase [UDP-forming] [Tribolium castaneum] 820834819 XM_003689675.2 267 6.04856e-135 PREDICTED: Apis florea alpha,alpha-trehalose-phosphate synthase [UDP-forming]-like (LOC100865289), mRNA K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 G4RK44 987 3.4e-105 Bifunctional trehalose-6-phosphate synthase/phosphatase OS=Thermoproteus tenax (strain ATCC 35583 / NBRC 100435 / JCM 9277 / Kra 1) GN=tpsp PE=1 SV=1 PF02358//PF00982 Trehalose-phosphatase//Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.37023 BF_2 237.26 7.78 1563 546677249 ERL88118.1 1370 1.4e-148 hypothetical protein D910_05507 [Dendroctonus ponderosae] 642931316 XM_008198307.1 358 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 1045 2.8e-112 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0003774//GO:0005524 motor activity//ATP binding GO:0016459 myosin complex -- -- Cluster-8309.37024 BF_2 1420.81 102.15 869 264667459 ACY71315.1 524 9.8e-51 ribosomal protein L28 [Chrysomela tremula] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 427 7.1e-41 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-8309.37026 BF_2 30411.65 906.87 1690 478250933 ENN71418.1 1948 1.4e-215 hypothetical protein YQE_11922, partial [Dendroctonus ponderosae] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q6B855 1593 8.6e-176 Transketolase OS=Bos taurus GN=TKT PE=2 SV=1 PF13292//PF02775//PF00676 1-deoxy-D-xylulose-5-phosphate synthase//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Dehydrogenase E1 component GO:0006694//GO:0016114//GO:0008152 steroid biosynthetic process//terpenoid biosynthetic process//metabolic process GO:0030976//GO:0008661//GO:0016624//GO:0003824 thiamine pyrophosphate binding//1-deoxy-D-xylulose-5-phosphate synthase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity -- -- KOG0523 Transketolase Cluster-8309.37029 BF_2 119.00 1.06 4967 546683557 ERL93355.1 4599 0.0e+00 hypothetical protein D910_10647, partial [Dendroctonus ponderosae] -- -- -- -- -- K10521 ABTB2 ankyrin repeat and BTB/POZ domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10521 Q7TQI7 1604 1.3e-176 Ankyrin repeat and BTB/POZ domain-containing protein 2 OS=Mus musculus GN=Abtb2 PE=2 SV=1 PF13606//PF00651//PF00023//PF01466 Ankyrin repeat//BTB/POZ domain//Ankyrin repeat//Skp1 family, dimerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.3703 BF_2 5.00 0.31 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37031 BF_2 120059.79 1098.30 4860 642931268 XP_008196506.1 3052 0.0e+00 PREDICTED: myosin heavy chain, muscle isoform X1 [Tribolium castaneum]>gi|642931270|ref|XP_008196507.1| PREDICTED: myosin heavy chain, muscle isoform X1 [Tribolium castaneum] 642931316 XM_008198307.1 1525 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2869 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00038//PF00769//PF01576//PF09177 Intermediate filament protein//Ezrin/radixin/moesin family//Myosin tail//Syntaxin 6, N-terminal GO:0048193 Golgi vesicle transport GO:0003774//GO:0008092//GO:0005198 motor activity//cytoskeletal protein binding//structural molecule activity GO:0016020//GO:0005737//GO:0016459//GO:0019898//GO:0005882 membrane//cytoplasm//myosin complex//extrinsic component of membrane//intermediate filament -- -- Cluster-8309.37033 BF_2 5554.34 335.36 980 646701257 KDR11062.1 615 3.1e-61 ATP synthase subunit beta, mitochondrial [Zootermopsis nevadensis] 170040304 XM_001847892.1 228 7.81154e-114 Culex quinquefasciatus ATP synthase beta subunit, mRNA K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 Q05825 581 1.1e-58 ATP synthase subunit beta, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-beta PE=1 SV=3 PF00306 ATP synthase alpha/beta chain, C terminal domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-8309.37034 BF_2 28.04 0.42 3103 546681394 ERL91491.1 344 2.6e-29 hypothetical protein D910_08821 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W303 215 9.7e-16 Chitinase-like protein Idgf4 OS=Drosophila melanogaster GN=Idgf4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37037 BF_2 6911.22 74.96 4144 642933491 XP_008197440.1 2917 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 257 2.56562e-129 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1747 2.9e-193 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0008152 metabolic process GO:0003723//GO:0003824//GO:0019843 RNA binding//catalytic activity//rRNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.37038 BF_2 17.00 0.60 1477 391348191 XP_003748333.1 1504 3.8e-164 PREDICTED: probable serine carboxypeptidase CPVL-like isoform 1 [Metaseiulus occidentalis] -- -- -- -- -- K09645 CPVL vitellogenic carboxypeptidase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K09645 Q9H3G5 1208 3.3e-131 Probable serine carboxypeptidase CPVL OS=Homo sapiens GN=CPVL PE=1 SV=2 PF00450 Serine carboxypeptidase GO:0006508 proteolysis GO:0004185 serine-type carboxypeptidase activity -- -- KOG1282 Serine carboxypeptidases (lysosomal cathepsin A) Cluster-8309.37039 BF_2 2386.94 118.47 1130 270016484 EFA12930.1 300 1.2e-24 hypothetical protein TcasGA2_TC010476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35554 173 2.6e-11 Flightin OS=Drosophila melanogaster GN=fln PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.3704 BF_2 3.00 0.31 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37040 BF_2 399.05 4.59 3921 642928001 XP_008195479.1 1414 2.8e-153 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] -- -- -- -- -- K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 Q9Y4C0 532 2.1e-52 Neurexin-3 OS=Homo sapiens GN=NRXN3 PE=1 SV=4 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.37041 BF_2 35679.38 8021.02 473 401871116 AFQ23943.1 142 1.0e-06 Kunitz-like protease inhibitor [Pomacea canaliculata] -- -- -- -- -- -- -- -- -- O54819 139 9.6e-08 Tissue factor pathway inhibitor OS=Mus musculus GN=Tfpi PE=2 SV=1 PF00014//PF07127 Kunitz/Bovine pancreatic trypsin inhibitor domain//Late nodulin protein GO:0009878 nodule morphogenesis GO:0004867//GO:0046872 serine-type endopeptidase inhibitor activity//metal ion binding -- -- -- -- Cluster-8309.37044 BF_2 24.21 0.33 3363 546684179 ERL93884.1 999 3.2e-105 hypothetical protein D910_11170 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05319 423 8.0e-40 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.37045 BF_2 353.09 3.71 4271 642912316 XP_969236.2 2536 2.4e-283 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BZW8 1281 3.3e-139 NHL repeat-containing protein 2 OS=Mus musculus GN=Nhlrc2 PE=2 SV=1 PF01731//PF00085//PF01436 Arylesterase//Thioredoxin//NHL repeat GO:0045454 cell redox homeostasis GO:0004064//GO:0005515 arylesterase activity//protein binding -- -- -- -- Cluster-8309.37047 BF_2 947.12 15.55 2835 58294539 AAW70172.1 2594 3.0e-290 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 972 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 1798 2.5e-199 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.37048 BF_2 622.00 10.91 2672 270006004 EFA02452.1 1564 7.6e-171 hypothetical protein TcasGA2_TC008139 [Tribolium castaneum] 642920079 XM_001815999.2 143 3.88203e-66 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- Q497V6 513 2.3e-50 Bromo adjacent homology domain-containing 1 protein OS=Mus musculus GN=Bahd1 PE=2 SV=1 PF01426//PF00608 BAH domain//Adenoviral fibre protein (repeat/shaft region) GO:0009405//GO:0019062//GO:0007155 pathogenesis//virion attachment to host cell//cell adhesion GO:0003682 chromatin binding GO:0000785 chromatin KOG1886 BAH domain proteins Cluster-8309.37050 BF_2 8039.69 272.80 1520 478250717 ENN71209.1 632 5.1e-63 hypothetical protein YQE_12138, partial [Dendroctonus ponderosae]>gi|546678600|gb|ERL89182.1| hypothetical protein D910_06556 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P86383 169 1.0e-10 Lysozyme OS=Meretrix lusoria PE=1 SV=1 PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.37051 BF_2 997.56 5.81 7474 507228 AAA64736.1 693 2.1e-69 apolipophorin-III, partial [Derobrachus geminatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04513//PF02601//PF04799//PF06320//PF14942//PF06109//PF01474//PF10150//PF02993//PF05531//PF06008//PF05478//PF01442//PF10280//PF07464//PF03623//PF04108//PF05823//PF00804//PF06667//PF00430//PF05866 Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//fzo-like conserved region//GCN5-like protein 1 (GCN5L1)//Organelle biogenesis, Muted-like protein//Haemolysin E (HlyE)//Class-II DAHP synthetase family//Ribonuclease E/G family//Minor capsid protein VI//Nucleopolyhedrovirus P10 protein//Laminin Domain I//Prominin//Apolipoprotein A1/A4/E domain//Mediator complex protein//Apolipophorin-III precursor (apoLp-III)//Focal adhesion targeting region//Autophagy protein Apg17//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Syntaxin//Phage shock protein B//ATP synthase B/B' CF(0)//Endodeoxyribonuclease RusA GO:0006355//GO:0006914//GO:0006468//GO:0006281//GO:0030334//GO:0044179//GO:0009405//GO:0007165//GO:0009271//GO:0006308//GO:0030155//GO:0009094//GO:0015986//GO:0006869//GO:0042157//GO:0015992//GO:0006571//GO:0045995//GO:0006357//GO:0000162//GO:0009073//GO:0008053//GO:0006310//GO:0007172 regulation of transcription, DNA-templated//autophagy//protein phosphorylation//DNA repair//regulation of cell migration//hemolysis in other organism//pathogenesis//signal transduction//phage shock//DNA catabolic process//regulation of cell adhesion//L-phenylalanine biosynthetic process//ATP synthesis coupled proton transport//lipid transport//lipoprotein metabolic process//proton transport//tyrosine biosynthetic process//regulation of embryonic development//regulation of transcription from RNA polymerase II promoter//tryptophan biosynthetic process//aromatic amino acid family biosynthetic process//mitochondrial fusion//DNA recombination//signal complex assembly GO:0015078//GO:0003849//GO:0005198//GO:0000287//GO:0004871//GO:0008855//GO:0004713//GO:0003723//GO:0005102//GO:0003924//GO:0008289//GO:0001104 hydrogen ion transmembrane transporter activity//3-deoxy-7-phosphoheptulonate synthase activity//structural molecule activity//magnesium ion binding//signal transducer activity//exodeoxyribonuclease VII activity//protein tyrosine kinase activity//RNA binding//receptor binding//GTPase activity//lipid binding//RNA polymerase II transcription cofactor activity GO:0045263//GO:0016021//GO:0030133//GO:0005576//GO:0005741//GO:0016020//GO:0019031//GO:0009318//GO:0019028//GO:0005925//GO:0031083//GO:0016592 proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane//transport vesicle//extracellular region//mitochondrial outer membrane//membrane//viral envelope//exodeoxyribonuclease VII complex//viral capsid//focal adhesion//BLOC-1 complex//mediator complex -- -- Cluster-8309.37052 BF_2 918.00 129.35 584 270004992 EFA01440.1 344 4.9e-30 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 306 5.1e-27 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF15952 Enhancer of split M4 family GO:0007423//GO:0007219 sensory organ development//Notch signaling pathway -- -- -- -- -- -- Cluster-8309.37053 BF_2 6.00 22.44 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37056 BF_2 530.20 4.31 5437 642932670 XP_008196939.1 401 1.1e-35 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 4.8e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF02179//PF09198 BAG domain//Bacteriophage T4 beta-glucosyltransferase GO:0006304 DNA modification GO:0051087//GO:0033821 chaperone binding//DNA beta-glucosyltransferase activity -- -- -- -- Cluster-8309.37057 BF_2 52.31 0.39 5911 642915851 XP_008196212.1 746 1.2e-75 PREDICTED: gamma-glutamyl hydrolase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 426 6.3e-40 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722 Peptidase C26 GO:0006541 glutamine metabolic process GO:0016787 hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.37058 BF_2 1622.00 103.93 940 91078958 XP_974220.1 587 5.2e-58 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 803278454 XM_012143513.1 58 2.37932e-19 PREDICTED: Ovis aries musimon cathepsin B (CTSB), transcript variant X4, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 Q4R5M2 482 3.2e-47 Cathepsin B OS=Macaca fascicularis GN=CTSB PE=2 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37059 BF_2 337.16 2.61 5699 642931308 XP_008196526.1 2541 8.4e-284 PREDICTED: myosin heavy chain, muscle isoform X22 [Tribolium castaneum] 642931316 XM_008198307.1 805 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2245 7.2e-251 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF08001//PF02419//PF05060//PF02736//PF00063 CMV US//PsbL protein//N-acetylglucosaminyltransferase II (MGAT2)//Myosin N-terminal SH3-like domain//Myosin head (motor domain) GO:0015979//GO:0009312//GO:0030683 photosynthesis//oligosaccharide biosynthetic process//evasion or tolerance by virus of host immune response GO:0005524//GO:0008455//GO:0003774 ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity//motor activity GO:0016021//GO:0016459//GO:0016020//GO:0005795//GO:0044386//GO:0009539//GO:0009523 integral component of membrane//myosin complex//membrane//Golgi stack//integral to host endoplasmic reticulum membrane//photosystem II reaction center//photosystem II KOG0161 Myosin class II heavy chain Cluster-8309.3706 BF_2 7.63 0.38 1127 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37060 BF_2 77627.96 589.37 5797 642931284 XP_008196514.1 3465 0.0e+00 PREDICTED: myosin heavy chain, muscle isoform X8 [Tribolium castaneum] 642931316 XM_008198307.1 1081 0 PREDICTED: Tribolium castaneum myosin heavy chain 1 (LOC659358), transcript variant X29, mRNA K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 3056 0.0e+00 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF05060//PF02736//PF00063//PF08001 N-acetylglucosaminyltransferase II (MGAT2)//Myosin N-terminal SH3-like domain//Myosin head (motor domain)//CMV US GO:0030683//GO:0009312 evasion or tolerance by virus of host immune response//oligosaccharide biosynthetic process GO:0003774//GO:0005524//GO:0008455 motor activity//ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0005795//GO:0044386//GO:0016021//GO:0016459 Golgi stack//integral to host endoplasmic reticulum membrane//integral component of membrane//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.37061 BF_2 10024.32 67.78 6474 478257766 ENN77909.1 2079 3.5e-230 hypothetical protein YQE_05586, partial [Dendroctonus ponderosae] -- -- -- -- -- K19030 PFKFB4 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K19030 Q91348 901 5.8e-95 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Gallus gallus PE=2 SV=2 PF01591//PF07728//PF01583//PF00910//PF07967//PF00005//PF05485//PF06414 6-phosphofructo-2-kinase//AAA domain (dynein-related subfamily)//Adenylylsulphate kinase//RNA helicase//C3HC zinc finger-like//ABC transporter//THAP domain//Zeta toxin GO:0000103//GO:0006144//GO:0006000//GO:0006013 sulfate assimilation//purine nucleobase metabolic process//fructose metabolic process//mannose metabolic process GO:0003723//GO:0005524//GO:0004020//GO:0003873//GO:0016887//GO:0016301//GO:0003676//GO:0008270//GO:0003724 RNA binding//ATP binding//adenylylsulfate kinase activity//6-phosphofructo-2-kinase activity//ATPase activity//kinase activity//nucleic acid binding//zinc ion binding//RNA helicase activity GO:0005634 nucleus KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.37062 BF_2 288.00 4.26 3112 642925507 XP_008194579.1 1692 1.3e-185 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.75603e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 P47820 1164 8.8e-126 Angiotensin-converting enzyme OS=Rattus norvegicus GN=Ace PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.37063 BF_2 4859.13 35.49 6014 91081899 XP_976020.1 1589 2.2e-173 PREDICTED: cyclin-Y-like protein 1 [Tribolium castaneum]>gi|270007331|gb|EFA03779.1| hypothetical protein TcasGA2_TC013890 [Tribolium castaneum] 620962625 XM_007667839.1 113 4.18097e-49 PREDICTED: Ornithorhynchus anatinus cyclin Y (CCNY), mRNA K07881 RAB14 Ras-related protein Rab-14 http://www.genome.jp/dbget-bin/www_bget?ko:K07881 Q6NRF4 988 4.4e-105 Cyclin-Y-like protein 1-B OS=Xenopus laevis GN=ccnyl1-b PE=2 SV=1 PF03193//PF01428//PF00071//PF04670//PF08613//PF01926//PF00735//PF08477//PF00025 Protein of unknown function, DUF258//AN1-like Zinc finger//Ras family//Gtr1/RagA G protein conserved region//Cyclin//50S ribosome-binding GTPase//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family GO:0000079//GO:0007264 regulation of cyclin-dependent protein serine/threonine kinase activity//small GTPase mediated signal transduction GO:0003924//GO:0019901//GO:0008270//GO:0005525 GTPase activity//protein kinase binding//zinc ion binding//GTP binding -- -- KOG1675 Predicted cyclin Cluster-8309.37064 BF_2 985.36 3.71 11401 642925080 XP_008194161.1 4665 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A1 [Tribolium castaneum] 573902448 XM_006638886.1 156 9.92081e-73 PREDICTED: Lepisosteus oculatus lysine-specific demethylase 6A-like (LOC102692642), transcript variant X4, mRNA K14950 ATP13A1 cation-transporting ATPase 13A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14950 Q9HD20 3312 0.0e+00 Manganese-transporting ATPase 13A1 OS=Homo sapiens GN=ATP13A1 PE=1 SV=2 PF13414//PF02388//PF00122//PF03938//PF00782//PF00515//PF13949//PF00102//PF08797//PF13181 TPR repeat//FemAB family//E1-E2 ATPase//Outer membrane protein (OmpH-like)//Dual specificity phosphatase, catalytic domain//Tetratricopeptide repeat//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//HIRAN domain//Tetratricopeptide repeat GO:0006570//GO:0006470//GO:0009252 tyrosine metabolic process//protein dephosphorylation//peptidoglycan biosynthetic process GO:0008138//GO:0005515//GO:0004725//GO:0016755//GO:0016818//GO:0046872//GO:0000166//GO:0008270//GO:0051082//GO:0003676 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//transferase activity, transferring amino-acyl groups//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//metal ion binding//nucleotide binding//zinc ion binding//unfolded protein binding//nucleic acid binding -- -- KOG0209 P-type ATPase Cluster-8309.37065 BF_2 92.79 8.77 730 264667371 ACY71271.1 744 2.5e-76 ribosomal protein S19 [Chrysomela tremula] -- -- -- -- -- K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 P39018 541 3.6e-54 40S ribosomal protein S19a OS=Drosophila melanogaster GN=RpS19a PE=1 SV=3 PF01090 Ribosomal protein S19e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.37066 BF_2 8207.17 70.95 5126 546677329 ERL88186.1 1874 1.7e-206 hypothetical protein D910_05574 [Dendroctonus ponderosae] -- -- -- -- -- K17407 MRPS28 small subunit ribosomal protein S28 http://www.genome.jp/dbget-bin/www_bget?ko:K17407 Q9CY16 207 1.4e-14 28S ribosomal protein S28, mitochondrial OS=Mus musculus GN=Mrps28 PE=1 SV=1 PF06788 Uncharacterised protein family (UPF0257) -- -- -- -- GO:0005886 plasma membrane KOG4078 Putative mitochondrial ribosomal protein mRpS35 Cluster-8309.37067 BF_2 514.97 8.70 2762 642911657 XP_001810552.2 2390 1.3e-266 PREDICTED: double-stranded RNA-binding protein Staufen homolog 2 isoform X3 [Tribolium castaneum] 642911656 XM_001810500.2 174 2.34711e-83 PREDICTED: Tribolium castaneum staufen (LOC657623), transcript variant X3, mRNA K17597 STAU double-stranded RNA-binding protein Staufen http://www.genome.jp/dbget-bin/www_bget?ko:K17597 Q7ZW47 792 1.1e-82 Double-stranded RNA-binding protein Staufen homolog 2 OS=Danio rerio GN=stau2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3732 Staufen and related double-stranded-RNA-binding proteins Cluster-8309.37068 BF_2 3050.34 18.00 7376 478255753 ENN75962.1 7220 0.0e+00 hypothetical protein YQE_07496, partial [Dendroctonus ponderosae]>gi|546683628|gb|ERL93416.1| hypothetical protein D910_10708 [Dendroctonus ponderosae] 462326123 APGK01041549.1 824 0 Dendroctonus ponderosae Seq01041559, whole genome shotgun sequence K10352 MYH myosin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K10352 Q99323 6044 0.0e+00 Myosin heavy chain, non-muscle OS=Drosophila melanogaster GN=zip PE=1 SV=2 PF08471//PF01576//PF00063//PF00612 Class II vitamin B12-dependent ribonucleotide reductase//Myosin tail//Myosin head (motor domain)//IQ calmodulin-binding motif GO:0006206//GO:0055114//GO:0009186//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0003774//GO:0050897//GO:0005524//GO:0004748//GO:0005515 motor activity//cobalt ion binding//ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//protein binding GO:0016459//GO:0005971 myosin complex//ribonucleoside-diphosphate reductase complex KOG0161 Myosin class II heavy chain Cluster-8309.37069 BF_2 562.65 11.48 2338 91078140 XP_973588.1 930 2.2e-97 PREDICTED: uncharacterized protein LOC662397 [Tribolium castaneum]>gi|270002341|gb|EEZ98788.1| hypothetical protein TcasGA2_TC001352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P87053 135 1.4e-06 F-box/WD repeat-containing protein pof1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pof1 PE=1 SV=1 PF00400//PF06516 WD domain, G-beta repeat//Purine nucleoside permease (NUP) GO:0055085 transmembrane transport GO:0005515 protein binding -- -- -- -- Cluster-8309.37070 BF_2 628.00 57.76 742 817011233 AKF11870.1 605 3.4e-60 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR6 507 3.2e-50 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.37071 BF_2 872.00 33.84 1365 546676821 ERL87767.1 952 3.6e-100 hypothetical protein D910_05156 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q9VSL3 564 1.5e-56 Pyrimidodiazepine synthase OS=Drosophila melanogaster GN=se PE=1 SV=1 PF13417//PF00462//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0009055//GO:0015035 protein binding//electron carrier activity//protein disulfide oxidoreductase activity -- -- KOG0406 Glutathione S-transferase Cluster-8309.37072 BF_2 115.90 2.04 2658 546681405 ERL91502.1 1601 3.9e-175 hypothetical protein D910_08832 [Dendroctonus ponderosae] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37073 BF_2 2684.84 10.11 11393 270003480 EEZ99927.1 5528 0.0e+00 hypothetical protein TcasGA2_TC002723 [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 726 2.0e-74 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 PF03554//PF03110//PF03547 UL73 viral envelope glycoprotein//SBP domain//Membrane transport protein GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0019031//GO:0016021//GO:0005634 viral envelope//integral component of membrane//nucleus KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.37075 BF_2 82.45 9.30 658 270011903 EFA08351.1 810 5.1e-84 hypothetical protein TcasGA2_TC005994 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18016 140 1.0e-07 Ig-like and fibronectin type-III domain-containing protein T04A11.3 OS=Caenorhabditis elegans GN=T04A11.3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37076 BF_2 8.00 0.73 745 557763662 XP_005181542.1 655 5.4e-66 PREDICTED: moesin/ezrin/radixin homolog 1 [Musca domestica] 268588968 FJ825625.1 561 0 Scylla paramamosain moesin/ezrin/radixin-like protein mRNA, partial cds -- -- -- -- Q29GR8 649 1.1e-66 Moesin/ezrin/radixin homolog 1 OS=Drosophila pseudoobscura pseudoobscura GN=Moe PE=3 SV=3 PF05531//PF06009//PF00769//PF10392 Nucleopolyhedrovirus P10 protein//Laminin Domain II//Ezrin/radixin/moesin family//Golgi transport complex subunit 5 GO:0006891//GO:0007155 intra-Golgi vesicle-mediated transport//cell adhesion GO:0008092 cytoskeletal protein binding GO:0017119//GO:0019898//GO:0019028//GO:0005737 Golgi transport complex//extrinsic component of membrane//viral capsid//cytoplasm KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.37077 BF_2 261.85 0.59 18769 612342210 AHW99830.1 21219 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1873 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 17872 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00520//PF06459//PF00487//PF06423//PF05372//PF01365//PF03348//PF00622//PF13499//PF13833//PF05366//PF02815 Ion transport protein//Ryanodine Receptor TM 4-6//Fatty acid desaturase//GWT1//Delta lysin family//RIH domain//Serine incorporator (Serinc)//SPRY domain//EF-hand domain pair//EF-hand domain pair//Sarcolipin//MIR domain GO:0006629//GO:0006506//GO:0019836//GO:0006811//GO:0055085//GO:0006816//GO:0070588//GO:0006874 lipid metabolic process//GPI anchor biosynthetic process//hemolysis by symbiont of host erythrocytes//ion transport//transmembrane transport//calcium ion transport//calcium ion transmembrane transport//cellular calcium ion homeostasis GO:0005262//GO:0005515//GO:0005219//GO:0016746//GO:0005509//GO:0005216//GO:0030234 calcium channel activity//protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium ion binding//ion channel activity//enzyme regulator activity GO:0005789//GO:0016020//GO:0005576//GO:0016021//GO:0005622 endoplasmic reticulum membrane//membrane//extracellular region//integral component of membrane//intracellular KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.37079 BF_2 252.52 2.02 5510 642921981 XP_008192968.1 2946 0.0e+00 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 891 7.1e-94 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF06330 alpha/beta hydrolase fold//Trichodiene synthase (TRI5) GO:0016114//GO:0016106//GO:0008152 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process//metabolic process GO:0045482//GO:0016787 trichodiene synthase activity//hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.37080 BF_2 66.29 0.82 3657 270003759 EFA00207.1 1137 3.4e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.3594e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.3e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.37081 BF_2 894.95 15.85 2649 478260541 ENN80244.1 472 3.2e-44 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911792 XM_008202523.1 94 6.67121e-39 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X2, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q12974 311 6.1e-27 Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens GN=PTP4A2 PE=1 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.37082 BF_2 149.54 3.78 1942 91076522 XP_973518.1 1440 1.3e-156 PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|642912580|ref|XP_008200918.1| PREDICTED: programmed cell death protein 4 isoform X1 [Tribolium castaneum]>gi|270002610|gb|EEZ99057.1| hypothetical protein TcasGA2_TC004932 [Tribolium castaneum] 669193686 KF516645.1 38 6.56868e-08 Paracyclopina nana programmed cell death protein 4 mRNA, partial cds K16865 PDCD4 programmed cell death protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16865 Q98TX3 606 2.8e-61 Programmed cell death protein 4 OS=Gallus gallus GN=PDCD4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0403 Neoplastic transformation suppressor Pdcd4/MA-3, contains MA3 domain Cluster-8309.37083 BF_2 78.63 1.31 2801 546681841 ERL91856.1 1742 1.8e-191 hypothetical protein D910_09181 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15582 494 3.9e-48 Transforming growth factor-beta-induced protein ig-h3 OS=Homo sapiens GN=TGFBI PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.37084 BF_2 35163.44 460.85 3479 805752828 XP_012154051.1 3879 0.0e+00 PREDICTED: alpha-actinin, sarcomeric isoform X2 [Megachile rotundata] 755976945 XM_011309818.1 777 0 PREDICTED: Fopius arisanus alpha-actinin, sarcomeric (LOC105269505), transcript variant X2, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q7PKQ5 3744 0.0e+00 Alpha-actinin, sarcomeric OS=Anopheles gambiae GN=Actn PE=3 SV=2 PF00307//PF13202//PF13499//PF13833//PF13405//PF00036//PF00435 Calponin homology (CH) domain//EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Spectrin repeat -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8309.37085 BF_2 96.82 1.44 3102 270013236 EFA09684.1 1254 7.8e-135 hypothetical protein TcasGA2_TC011812 [Tribolium castaneum] 665818146 XM_008559662.1 44 4.87732e-11 PREDICTED: Microplitis demolitor serine/threonine-protein kinase 17B-like (LOC103578532), mRNA K08804 STK17 serine/threonine kinase 17 http://www.genome.jp/dbget-bin/www_bget?ko:K08804 Q0KHT7 691 6.2e-71 Death-associated protein kinase related OS=Drosophila melanogaster GN=Drak PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.37086 BF_2 1400.71 18.36 3479 642929255 XP_008195756.1 2075 5.5e-230 PREDICTED: PX domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270009666|gb|EFA06114.1| hypothetical protein TcasGA2_TC008957 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q7Z7A4 1138 1.0e-122 PX domain-containing protein kinase-like protein OS=Homo sapiens GN=PXK PE=1 SV=1 PF07714//PF00787//PF02569//PF00069//PF02285//PF02205 Protein tyrosine kinase//PX domain//Pantoate-beta-alanine ligase//Protein kinase domain//Cytochrome oxidase c subunit VIII//WH2 motif GO:0019482//GO:0015992//GO:0007154//GO:0006123//GO:0015940//GO:0006468 beta-alanine metabolic process//proton transport//cell communication//mitochondrial electron transport, cytochrome c to oxygen//pantothenate biosynthetic process//protein phosphorylation GO:0004592//GO:0004129//GO:0004672//GO:0005524//GO:0003779//GO:0035091 pantoate-beta-alanine ligase activity//cytochrome-c oxidase activity//protein kinase activity//ATP binding//actin binding//phosphatidylinositol binding GO:0045277 respiratory chain complex IV KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.37087 BF_2 196.19 4.66 2048 642916102 XP_971729.2 1773 3.4e-195 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5R7H5 1232 7.6e-134 DDB1- and CUL4-associated factor 11 OS=Pongo abelii GN=DCAF11 PE=2 SV=2 PF00400//PF04053 WD domain, G-beta repeat//Coatomer WD associated region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0266 WD40 repeat-containing protein Cluster-8309.37088 BF_2 595.84 29.50 1132 270016479 EFA12925.1 219 3.0e-15 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00690 128 4.3e-06 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37089 BF_2 1155.82 6.40 7840 478257467 ENN77623.1 2094 7.8e-232 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 101 2.55628e-42 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1672 2.8e-184 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF13639//PF15965//PF02880//PF00076//PF09726//PF02878//PF02879//PF16672//PF14634//PF00097 Ring finger domain//TRAF-like zinc-finger//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Ragulator complex protein LAMTOR5//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0005975//GO:0043154//GO:0043066//GO:0019079 carbohydrate metabolic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//negative regulation of apoptotic process//viral genome replication GO:0046872//GO:0016868//GO:0003676//GO:0008270//GO:0005515 metal ion binding//intramolecular transferase activity, phosphotransferases//nucleic acid binding//zinc ion binding//protein binding GO:0005737//GO:0071986//GO:0016021 cytoplasm//Ragulator complex//integral component of membrane KOG0625 Phosphoglucomutase Cluster-8309.37090 BF_2 1166.87 7.02 7243 478257467 ENN77623.1 2412 9.7e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 101 2.36071e-42 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 3.3e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF00097//PF00408//PF14634//PF16672//PF00076//PF02880//PF13639//PF02879//PF02878 Zinc finger, C3HC4 type (RING finger)//Phosphoglucomutase/phosphomannomutase, C-terminal domain//zinc-RING finger domain//Ragulator complex protein LAMTOR5//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Ring finger domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0019079//GO:0071704//GO:0043066//GO:0043154//GO:0005975 viral genome replication//organic substance metabolic process//negative regulation of apoptotic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//carbohydrate metabolic process GO:0005515//GO:0008270//GO:0003676//GO:0016868//GO:0046872 protein binding//zinc ion binding//nucleic acid binding//intramolecular transferase activity, phosphotransferases//metal ion binding GO:0071986//GO:0005737 Ragulator complex//cytoplasm KOG0625 Phosphoglucomutase Cluster-8309.37091 BF_2 7100.35 39.38 7829 478249702 ENN70210.1 2311 5.4e-257 hypothetical protein YQE_12996, partial [Dendroctonus ponderosae] 768412858 XM_011570222.1 40 2.07353e-08 PREDICTED: Plutella xylostella titin (LOC105398171), mRNA -- -- -- -- Q8IIG7 171 3.1e-10 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF17123//PF02984//PF00312 RING-like zinc finger//Cyclin, C-terminal domain//Ribosomal protein S15 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0008270//GO:0005515 structural constituent of ribosome//zinc ion binding//protein binding GO:0005840//GO:0005622//GO:0005634 ribosome//intracellular//nucleus -- -- Cluster-8309.37093 BF_2 219.23 4.69 2244 91085211 XP_972225.1 1563 8.4e-171 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009079|gb|EFA05527.1| hypothetical protein TcasGA2_TC015714 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 951 3.2e-101 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00070//PF05199//PF02254//PF07992//PF05834//PF00732//PF01266 Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0006813//GO:0055114//GO:0016117 potassium ion transport//oxidation-reduction process//carotenoid biosynthetic process GO:0016491//GO:0050660//GO:0016614//GO:0016705 oxidoreductase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.37094 BF_2 1711.89 96.66 1028 478256915 ENN77084.1 414 6.6e-38 hypothetical protein YQE_06419, partial [Dendroctonus ponderosae] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37095 BF_2 14436.76 227.05 2947 642916360 XP_008190988.1 1937 4.7e-214 PREDICTED: protein disulfide-isomerase [Tribolium castaneum]>gi|270004199|gb|EFA00647.1| hypothetical protein TcasGA2_TC003523 [Tribolium castaneum] 358443111 JF777457.1 59 2.12421e-19 Heliconius erato control protein HCTL033 mRNA, partial cds K09580 PDIA1, P4HB protein disulfide-isomerase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K09580 P54399 1542 1.2e-169 Protein disulfide-isomerase OS=Drosophila melanogaster GN=Pdi PE=2 SV=1 PF00085//PF08534//PF01216//PF00578//PF00854//PF07912 Thioredoxin//Redoxin//Calsequestrin//AhpC/TSA family//POT family//ERp29, N-terminal domain GO:0055114//GO:0006118//GO:0009306//GO:0006810//GO:0006662//GO:0045454 oxidation-reduction process//obsolete electron transport//protein secretion//transport//glycerol ether metabolic process//cell redox homeostasis GO:0016209//GO:0009055//GO:0005509//GO:0015035//GO:0016853//GO:0005215//GO:0016491 antioxidant activity//electron carrier activity//calcium ion binding//protein disulfide oxidoreductase activity//isomerase activity//transporter activity//oxidoreductase activity GO:0016020//GO:0005783//GO:0005788 membrane//endoplasmic reticulum//endoplasmic reticulum lumen KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.37096 BF_2 40.11 1.62 1326 546683025 ERL92891.1 171 1.3e-09 hypothetical protein D910_10196 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.37098 BF_2 3192.27 21.99 6360 270007552 EFA04000.1 1548 1.3e-168 hypothetical protein TcasGA2_TC014149 [Tribolium castaneum] 642922772 XM_008195097.1 443 0 PREDICTED: Tribolium castaneum protein muscleblind (LOC100142119), mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 771 6.7e-80 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF06733//PF00642//PF03176 DEAD_2//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//MMPL family -- -- GO:0046872//GO:0005524//GO:0004003//GO:0003677 metal ion binding//ATP binding//ATP-dependent DNA helicase activity//DNA binding GO:0005657//GO:0016020 replication fork//membrane KOG2494 C3H1-type Zn-finger protein Cluster-8309.37099 BF_2 50.38 0.33 6673 91088789 XP_968000.1 1311 4.1e-141 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02833 361 2.5e-32 Insulin-like growth factor-binding protein complex acid labile subunit OS=Papio hamadryas GN=IGFALS PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.37100 BF_2 582.38 5.70 4560 270013525 EFA09973.1 4390 0.0e+00 hypothetical protein TcasGA2_TC012131 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 P10351 3893 0.0e+00 Xanthine dehydrogenase OS=Drosophila melanogaster GN=ry PE=2 SV=2 PF00111//PF01799//PF00941//PF02738 2Fe-2S iron-sulfur cluster binding domain//[2Fe-2S] binding domain//FAD binding domain in molybdopterin dehydrogenase//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0046872//GO:0016491//GO:0009055//GO:0051536 metal ion binding//oxidoreductase activity//electron carrier activity//iron-sulfur cluster binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.37101 BF_2 312.60 4.00 3554 642923250 XP_008193676.1 4549 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 438 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 2061 9.8e-230 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF13606//PF14634//PF00023//PF00569//PF06701 Ankyrin repeat//zinc-RING finger domain//Ankyrin repeat//Zinc finger, ZZ type//Mib_herc2 GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.37102 BF_2 37.75 0.59 2949 642935906 XP_008198223.1 2248 4.1e-250 PREDICTED: calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type isoform X3 [Tribolium castaneum] 645001298 XM_008211242.1 690 0 PREDICTED: Nasonia vitripennis calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type (LOC100113791), transcript variant X6, mRNA K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 P22700 2098 4.2e-234 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Drosophila melanogaster GN=Ca-P60A PE=1 SV=2 PF09264//PF00122 Vibrio cholerae sialidase, lectin insertion//E1-E2 ATPase -- -- GO:0000166//GO:0046872//GO:0033691 nucleotide binding//metal ion binding//sialic acid binding -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.37103 BF_2 118.95 10.68 753 642932344 XP_008197074.1 168 1.6e-09 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37104 BF_2 1959.77 8.18 10307 91088831 XP_970461.1 3072 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X1 [Tribolium castaneum]>gi|270012333|gb|EFA08781.1| hypothetical protein TcasGA2_TC006471 [Tribolium castaneum] 645001221 XM_001601899.3 112 2.58257e-48 PREDICTED: Nasonia vitripennis 60S ribosomal protein L34-like (LOC100113629), mRNA K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O88813 1719 1.3e-189 Long-chain-fatty-acid--CoA ligase 5 OS=Rattus norvegicus GN=Acsl5 PE=1 SV=1 PF01434//PF02601//PF16053//PF01363//PF07168//PF05008//PF00501//PF01199 Peptidase family M41//Exonuclease VII, large subunit//Mitochondrial 28S ribosomal protein S34//FYVE zinc finger//Ureide permease//Vesicle transport v-SNARE protein N-terminus//AMP-binding enzyme//Ribosomal protein L34e GO:0042254//GO:0006886//GO:0006308//GO:0006508//GO:0006412//GO:0008152//GO:0071705 ribosome biogenesis//intracellular protein transport//DNA catabolic process//proteolysis//translation//metabolic process//nitrogen compound transport GO:0003735//GO:0004222//GO:0005524//GO:0046872//GO:0008855//GO:0003824 structural constituent of ribosome//metalloendopeptidase activity//ATP binding//metal ion binding//exodeoxyribonuclease VII activity//catalytic activity GO:0005739//GO:0005840//GO:0009318//GO:0005622//GO:0016020 mitochondrion//ribosome//exodeoxyribonuclease VII complex//intracellular//membrane KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-8309.37106 BF_2 1640.00 11.39 6309 189236266 XP_974475.2 971 1.0e-101 PREDICTED: transmembrane protein 53 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ULP2 147 1.5e-07 Aftiphilin OS=Homo sapiens GN=AFTPH PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37107 BF_2 103.57 1.25 3766 91076374 XP_967954.1 2668 1.0e-298 PREDICTED: DNA ligase 3 [Tribolium castaneum]>gi|270002897|gb|EEZ99344.1| ligase III [Tribolium castaneum] -- -- -- -- -- K10776 LIG3 DNA ligase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10776 P49916 2068 1.6e-230 DNA ligase 3 OS=Homo sapiens GN=LIG3 PE=1 SV=2 PF04679//PF04675//PF00645//PF02229//PF01068 ATP dependent DNA ligase C terminal region//DNA ligase N terminus//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Transcriptional Coactivator p15 (PC4)//ATP dependent DNA ligase domain GO:0006355//GO:0006310//GO:0006260//GO:0006281 regulation of transcription, DNA-templated//DNA recombination//DNA replication//DNA repair GO:0003910//GO:0008270//GO:0000166//GO:0043167//GO:0003909//GO:0003713//GO:0005524//GO:0003677 DNA ligase (ATP) activity//zinc ion binding//nucleotide binding//ion binding//DNA ligase activity//transcription coactivator activity//ATP binding//DNA binding GO:0005667 transcription factor complex KOG0967 ATP-dependent DNA ligase I Cluster-8309.37109 BF_2 3558.24 22.56 6885 642934807 XP_008197818.1 2312 3.6e-257 PREDICTED: ninein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2I6 514 4.6e-50 Ninein-like protein OS=Homo sapiens GN=NINL PE=1 SV=2 PF10473//PF05837//PF15070//PF04479//PF13405//PF13499//PF04977//PF00170 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H)//Putative golgin subfamily A member 2-like protein 5//RTA1 like protein//EF-hand domain//EF-hand domain pair//Septum formation initiator//bZIP transcription factor GO:0007049//GO:0006355//GO:0051382//GO:0006950 cell cycle//regulation of transcription, DNA-templated//kinetochore assembly//response to stress GO:0003700//GO:0043565//GO:0042803//GO:0005509//GO:0045502//GO:0008134 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein homodimerization activity//calcium ion binding//dynein binding//transcription factor binding GO:0000776//GO:0005794//GO:0005667//GO:0030286//GO:0016021 kinetochore//Golgi apparatus//transcription factor complex//dynein complex//integral component of membrane KOG0161 Myosin class II heavy chain Cluster-8309.37111 BF_2 70.64 2.10 1697 242010990 XP_002426240.1 1041 2.1e-110 tubulin beta-1 chain [Pediculus humanus corporis]>gi|212510303|gb|EEB13502.1| tubulin beta-1 chain [Pediculus humanus corporis] 164683615 EU373305.1 686 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q27U48 1040 1.2e-111 Tubulin beta-1 chain OS=Glossina morsitans morsitans PE=2 SV=1 -- -- GO:0006184//GO:0051258//GO:0007018 obsolete GTP catabolic process//protein polymerization//microtubule-based movement GO:0005525//GO:0005198//GO:0003924 GTP binding//structural molecule activity//GTPase activity GO:0005737//GO:0005874 cytoplasm//microtubule KOG1375 Beta tubulin Cluster-8309.37112 BF_2 235.52 4.02 2739 546676745 ERL87701.1 384 5.3e-34 hypothetical protein D910_05091 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 131 4.7e-06 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37114 BF_2 750.48 31.53 1283 91092056 XP_970271.1 785 7.8e-81 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] -- -- -- -- -- K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 631 2.3e-64 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01180//PF02527//PF00977//PF01884 Dihydroorotate dehydrogenase//rRNA small subunit methyltransferase G//Histidine biosynthesis protein//PcrB family GO:0006364//GO:0006206//GO:0055114//GO:0000154//GO:0000105//GO:0006396//GO:0055086//GO:0072528 rRNA processing//pyrimidine nucleobase metabolic process//oxidation-reduction process//rRNA modification//histidine biosynthetic process//RNA processing//nucleobase-containing small molecule metabolic process//pyrimidine-containing compound biosynthetic process GO:0004152//GO:0016627//GO:0016765//GO:0008649 dihydroorotate dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//transferase activity, transferring alkyl or aryl (other than methyl) groups//rRNA methyltransferase activity GO:0005737 cytoplasm KOG1799 Dihydropyrimidine dehydrogenase Cluster-8309.37115 BF_2 3642.96 56.34 2992 189238490 XP_001809098.1 1250 2.2e-134 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|642926357|ref|XP_008194892.1| PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08799 136 1.4e-06 Myosin-2 heavy chain OS=Dictyostelium discoideum GN=mhcA PE=1 SV=3 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain GO:0043039 tRNA aminoacylation GO:0016876//GO:0005524 ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding -- -- -- -- Cluster-8309.37116 BF_2 14158.66 223.43 2938 189238490 XP_001809098.1 1279 9.4e-138 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|642926357|ref|XP_008194892.1| PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08799 136 1.3e-06 Myosin-2 heavy chain OS=Dictyostelium discoideum GN=mhcA PE=1 SV=3 PF07973 Threonyl and Alanyl tRNA synthetase second additional domain GO:0043039 tRNA aminoacylation GO:0005524//GO:0016876 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds -- -- -- -- Cluster-8309.37117 BF_2 37.65 0.36 4617 332376073 AEE63177.1 2225 3.0e-247 unknown [Dendroctonus ponderosae] 751798911 XM_011211092.1 84 4.23343e-33 PREDICTED: Bactrocera dorsalis probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (LOC105230362), mRNA K00140 mmsA, iolA, ALDH6A1 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00140 Q17M80 1919 3.7e-213 Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Aedes aegypti GN=AAEL001134 PE=3 SV=1 PF05893//PF00171 Acyl-CoA reductase (LuxC)//Aldehyde dehydrogenase family GO:0008152//GO:0006118//GO:0055114//GO:0008218 metabolic process//obsolete electron transport//oxidation-reduction process//bioluminescence GO:0003995//GO:0016491 acyl-CoA dehydrogenase activity//oxidoreductase activity -- -- KOG2449 Methylmalonate semialdehyde dehydrogenase Cluster-8309.37118 BF_2 1610.66 43.73 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37119 BF_2 40.21 0.37 4777 86515394 NP_001034522.1 1960 1.6e-216 pro-phenol oxidase subunit 2 [Tribolium castaneum]>gi|70999576|gb|AAX84205.1| pro-phenol oxidase subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V521 1727 7.1e-191 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 PF00264 Common central domain of tyrosinase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.37120 BF_2 32.00 5.70 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05001 RNA polymerase Rpb1 C-terminal repeat GO:0006366 transcription from RNA polymerase II promoter GO:0003677 DNA binding GO:0005665 DNA-directed RNA polymerase II, core complex -- -- Cluster-8309.37121 BF_2 1045.43 11.60 4057 642923252 XP_008193678.1 4686 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 390178834 XM_001359343.3 125 6.00194e-56 Drosophila pseudoobscura pseudoobscura GA18295 (Dpse\GA18295), partial mRNA K01191 E3.2.1.24 alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01191 Q8BRK9 1596 9.3e-176 Alpha-mannosidase 2x OS=Mus musculus GN=Man2a2 PE=2 SV=2 PF01074//PF07748//PF09261 Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Alpha mannosidase, middle domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0004553//GO:0008270//GO:0015923//GO:0004559 hydrolase activity, hydrolyzing O-glycosyl compounds//zinc ion binding//mannosidase activity//alpha-mannosidase activity -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.37123 BF_2 803.88 16.93 2274 642924570 XP_008194348.1 691 1.1e-69 PREDICTED: probable signal peptidase complex subunit 2 [Tribolium castaneum]>gi|270006751|gb|EFA03199.1| hypothetical protein TcasGA2_TC013119 [Tribolium castaneum] -- -- -- -- -- K12947 SPCS2, SPC2 signal peptidase complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12947 Q28250 519 4.0e-51 Signal peptidase complex subunit 2 OS=Canis familiaris GN=SPCS2 PE=1 SV=1 PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.37124 BF_2 7379.02 29.31 10820 642935792 XP_008198176.1 2065 2.5e-228 PREDICTED: nitric oxide synthase, salivary gland isoform X2 [Tribolium castaneum] 817198904 XM_012419693.1 44 1.7148e-10 PREDICTED: Orussus abietinus nitric oxide synthase, salivary gland (LOC105696887), transcript variant X5, mRNA K13240 NOS1 nitric-oxide synthase, brain http://www.genome.jp/dbget-bin/www_bget?ko:K13240 Q26240 1634 9.7e-180 Nitric oxide synthase, salivary gland OS=Rhodnius prolixus PE=2 SV=1 PF01040//PF00802//PF00175//PF04103//PF00335//PF09570//PF00667 UbiA prenyltransferase family//Pneumovirus attachment glycoprotein G//Oxidoreductase NAD-binding domain//CD20-like family//Tetraspanin family//SinI restriction endonuclease//FAD binding domain GO:0009307//GO:0055114//GO:0006308 DNA restriction-modification system//oxidation-reduction process//DNA catabolic process GO:0004659//GO:0009036//GO:0003677//GO:0016491 prenyltransferase activity//Type II site-specific deoxyribonuclease activity//DNA binding//oxidoreductase activity GO:0016021//GO:0055036//GO:0009359 integral component of membrane//virion membrane//Type II site-specific deoxyribonuclease complex KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.37125 BF_2 2914.61 16.54 7658 91084647 XP_966816.1 2888 0.0e+00 PREDICTED: carboxypeptidase D [Tribolium castaneum] 332374583 BT127471.1 238 1.73572e-118 Dendroctonus ponderosae clone DPO102_A24 unknown mRNA K07752 CPD carboxypeptidase D http://www.genome.jp/dbget-bin/www_bget?ko:K07752 P42787 2075 5.0e-231 Carboxypeptidase D OS=Drosophila melanogaster GN=svr PE=1 SV=2 PF00246//PF13499//PF13405//PF10591//PF13833//PF12763//PF08038//PF00036//PF01694//PF04952//PF13202 Zinc carboxypeptidase//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//TOM7 family//EF hand//Rhomboid family//Succinylglutamate desuccinylase / Aspartoacylase family//EF hand GO:0006508//GO:0030150//GO:0008152//GO:0007165 proteolysis//protein import into mitochondrial matrix//metabolic process//signal transduction GO:0004181//GO:0004252//GO:0005509//GO:0008270//GO:0005515//GO:0016788 metallocarboxypeptidase activity//serine-type endopeptidase activity//calcium ion binding//zinc ion binding//protein binding//hydrolase activity, acting on ester bonds GO:0005742//GO:0005578//GO:0016021 mitochondrial outer membrane translocase complex//proteinaceous extracellular matrix//integral component of membrane KOG2649 Zinc carboxypeptidase Cluster-8309.37126 BF_2 37.72 0.43 3930 642918236 XP_008191424.1 2733 3.1e-306 PREDICTED: uncharacterized protein LOC658718 [Tribolium castaneum] 642918235 XM_008193202.1 74 1.30346e-27 PREDICTED: Tribolium castaneum uncharacterized LOC658718 (LOC658718), mRNA -- -- -- -- -- -- -- -- PF00168//PF00130 C2 domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.37127 BF_2 9966.50 211.22 2261 270007221 EFA03669.1 298 4.1e-24 hypothetical protein TcasGA2_TC013767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.37131 BF_2 15.32 0.32 2307 270003872 EFA00320.1 1518 1.4e-165 hypothetical protein TcasGA2_TC003158 [Tribolium castaneum] 768434134 XM_011560159.1 268 1.08953e-135 PREDICTED: Plutella xylostella H(+)/Cl(-) exchange transporter 5-like (LOC105389096), mRNA K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 Q9GKE7 1035 6.0e-111 H(+)/Cl(-) exchange transporter 5 OS=Sus scrofa GN=CLCN5 PE=2 SV=1 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.37132 BF_2 265.90 2.67 4457 649572227 NP_001280512.1 6286 0.0e+00 clathrin heavy chain [Tribolium castaneum]>gi|270008499|gb|EFA04947.1| hypothetical protein TcasGA2_TC015014 [Tribolium castaneum]>gi|629511285|gb|AHY84716.1| clathrin heavy chain [Tribolium castaneum] 347969081 XM_003436308.1 1771 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 5737 0.0e+00 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF00231//PF01736//PF00637//PF04053//PF12937//PF13176//PF02806//PF00515//PF09268 ATP synthase//Polyomavirus agnoprotein//Region in Clathrin and VPS//Coatomer WD associated region//F-box-like//Tetratricopeptide repeat//Alpha amylase, C-terminal all-beta domain//Tetratricopeptide repeat//Clathrin, heavy-chain linker GO:0015992//GO:0005975//GO:0016192//GO:0006886//GO:0015986//GO:0006119 proton transport//carbohydrate metabolic process//vesicle-mediated transport//intracellular protein transport//ATP synthesis coupled proton transport//oxidative phosphorylation GO:0046933//GO:0046961//GO:0005198//GO:0043169//GO:0005515//GO:0003824//GO:0003677 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//structural molecule activity//cation binding//protein binding//catalytic activity//DNA binding GO:0030130//GO:0045259//GO:0030132//GO:0030117//GO:0045261 clathrin coat of trans-Golgi network vesicle//proton-transporting ATP synthase complex//clathrin coat of coated pit//membrane coat//proton-transporting ATP synthase complex, catalytic core F(1) KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.37133 BF_2 7264.66 284.59 1355 478257348 ENN77508.1 887 1.2e-92 hypothetical protein YQE_06034, partial [Dendroctonus ponderosae] -- -- -- -- -- K02127 ATPeF0B, ATP5F1, ATP4 F-type H+-transporting ATPase subunit b http://www.genome.jp/dbget-bin/www_bget?ko:K02127 Q94516 667 1.6e-68 ATP synthase subunit b, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-b PE=2 SV=2 PF05405 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3976 Mitochondrial F1F0-ATP synthase, subunit b/ATP4 Cluster-8309.37134 BF_2 28666.38 248.13 5120 58294539 AAW70172.1 3429 0.0e+00 transferrin [Apriona germari]>gi|88605021|gb|ABD46825.1| transferrin [Apriona germari] 58294538 AY894342.1 1244 0 Apriona germari transferrin mRNA, complete cds -- -- -- -- Q02942 2319 1.7e-259 Transferrin OS=Blaberus discoidalis PE=1 SV=1 -- -- GO:0006826//GO:0006879 iron ion transport//cellular iron ion homeostasis GO:0008199 ferric iron binding GO:0005576 extracellular region -- -- Cluster-8309.37135 BF_2 129.81 1.37 4256 642923836 XP_008193900.1 2211 1.2e-245 PREDICTED: LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells homolog [Tribolium castaneum] -- -- -- -- -- K10846 ERCC5, XPG, RAD2 DNA excision repair protein ERCC-5 http://www.genome.jp/dbget-bin/www_bget?ko:K10846 P28715 625 3.8e-63 DNA repair protein complementing XP-G cells OS=Homo sapiens GN=ERCC5 PE=1 SV=3 PF00752//PF03592//PF00867 XPG N-terminal domain//Terminase small subunit//XPG I-region GO:0006281//GO:0006323 DNA repair//DNA packaging GO:0004518 nuclease activity -- -- KOG2520 5'-3' exonuclease Cluster-8309.37136 BF_2 323.99 2.02 7006 546671490 ERL83783.1 805 2.1e-82 hypothetical protein D910_01021 [Dendroctonus ponderosae]>gi|546686735|gb|ERL95825.1| hypothetical protein D910_00390 [Dendroctonus ponderosae] 665817572 XM_008559342.1 66 6.52997e-23 PREDICTED: Microplitis demolitor iron-sulfur cluster assembly 1 homolog, mitochondrial (LOC103578320), partial mRNA K13628 iscA, ISCA1 iron-sulfur cluster assembly protein http://www.genome.jp/dbget-bin/www_bget?ko:K13628 Q4QRC6 514 4.7e-50 Iron-sulfur cluster assembly 1 homolog, mitochondrial OS=Danio rerio GN=isca1 PE=2 SV=1 PF12317//PF07882 Intraflagellar transport complex B protein 46 C terminal//L-fucose isomerase, second N-terminal domain GO:0006004//GO:0006000//GO:0042073//GO:0006013 fucose metabolic process//fructose metabolic process//intraciliary transport//mannose metabolic process GO:0008736 L-fucose isomerase activity GO:0005737 cytoplasm KOG1120 Fe-S cluster biosynthesis protein ISA1 (contains a HesB-like domain) Cluster-8309.37137 BF_2 71.56 1.15 2891 642931618 XP_008196658.1 1801 2.7e-198 PREDICTED: 6-phosphofructokinase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1616 3.2e-178 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006098//GO:0006096//GO:0006012//GO:0006094//GO:0006013//GO:0006000 pentose-phosphate shunt//glycolytic process//galactose metabolic process//gluconeogenesis//mannose metabolic process//fructose metabolic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.37138 BF_2 1142.49 8.67 5799 642922249 XP_008193077.1 3756 0.0e+00 PREDICTED: sodium bicarbonate cotransporter 3 isoform X1 [Tribolium castaneum]>gi|642922251|ref|XP_008193078.1| PREDICTED: sodium bicarbonate cotransporter 3 isoform X1 [Tribolium castaneum]>gi|642922253|ref|XP_008193079.1| PREDICTED: sodium bicarbonate cotransporter 3 isoform X1 [Tribolium castaneum] 642922254 XM_008194859.1 405 0 PREDICTED: Tribolium castaneum sodium bicarbonate cotransporter 3 (LOC661759), transcript variant X4, mRNA -- -- -- -- Q32LP4 2317 3.3e-259 Sodium-driven chloride bicarbonate exchanger OS=Bos taurus GN=SLC4A10 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.37139 BF_2 5659.54 20.48 11850 546679384 ERL89859.1 3289 0.0e+00 hypothetical protein D910_07218, partial [Dendroctonus ponderosae] 532092872 XM_005332061.1 187 6.03353e-90 PREDICTED: Spermophilus tridecemlineatus lysine (K)-specific demethylase 4B (Kdm4b), mRNA K06709 KDM4, JMJD2, JHDM3 jumonji domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06709 Q9V6L0 1585 5.1e-174 Probable lysine-specific demethylase 4B OS=Drosophila melanogaster GN=Kdm4B PE=3 SV=3 PF02102//PF00240//PF05033//PF00856//PF09280//PF14560//PF01299//PF01429 Deuterolysin metalloprotease (M35) family//Ubiquitin family//Pre-SET motif//SET domain//XPC-binding domain//Ubiquitin-like domain//Lysosome-associated membrane glycoprotein (Lamp)//Methyl-CpG binding domain GO:0034968//GO:0006281//GO:0006508//GO:0006479//GO:0006289//GO:0006554//GO:0043161 histone lysine methylation//DNA repair//proteolysis//protein methylation//nucleotide-excision repair//lysine catabolic process//proteasome-mediated ubiquitin-dependent protein catabolic process GO:0004222//GO:0003677//GO:0018024//GO:0005515//GO:0008270//GO:0003684 metalloendopeptidase activity//DNA binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding//damaged DNA binding GO:0005634//GO:0016020 nucleus//membrane KOG0958 DNA damage-responsive repressor GIS1/RPH1, jumonji superfamily Cluster-8309.37140 BF_2 140.80 0.54 11109 546675647 ERL86797.1 2468 4.8e-275 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 64 1.34202e-21 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 1433 2.0e-156 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF00454//PF02888//PF01189//PF00951//PF01728//PF01135//PF09446 Phosphatidylinositol 3- and 4-kinase//Calmodulin binding domain//16S rRNA methyltransferase RsmF//Arterivirus GL envelope glycoprotein//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//VMA21-like domain GO:0046500//GO:0032259//GO:0006479//GO:0006813//GO:0070072//GO:0006464 S-adenosylmethionine metabolic process//methylation//protein methylation//potassium ion transport//vacuolar proton-transporting V-type ATPase complex assembly//cellular protein modification process GO:0004719//GO:0016773//GO:0008168//GO:0015269//GO:0005516 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//phosphotransferase activity, alcohol group as acceptor//methyltransferase activity//calcium-activated potassium channel activity//calmodulin binding GO:0019031//GO:0016021 viral envelope//integral component of membrane -- -- Cluster-8309.37141 BF_2 381.27 1.68 9775 546675647 ERL86797.1 3344 0.0e+00 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 106 5.30069e-45 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 2100 8.1e-234 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF09446//PF01728//PF01135//PF00951//PF00454//PF02888//PF01189 VMA21-like domain//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Arterivirus GL envelope glycoprotein//Phosphatidylinositol 3- and 4-kinase//Calmodulin binding domain//16S rRNA methyltransferase RsmF GO:0032259//GO:0046500//GO:0006479//GO:0006813//GO:0070072//GO:0006464 methylation//S-adenosylmethionine metabolic process//protein methylation//potassium ion transport//vacuolar proton-transporting V-type ATPase complex assembly//cellular protein modification process GO:0016773//GO:0008168//GO:0004719//GO:0015269//GO:0005516 phosphotransferase activity, alcohol group as acceptor//methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//calcium-activated potassium channel activity//calmodulin binding GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) Cluster-8309.37142 BF_2 39.36 1.29 1568 332376242 AEE63261.1 479 2.9e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VCG3 407 2.7e-38 Putative OPA3-like protein CG13603 OS=Drosophila melanogaster GN=CG13601 PE=2 SV=1 PF02827 cAMP-dependent protein kinase inhibitor GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG3335 Predicted coiled-coil protein Cluster-8309.37143 BF_2 1447.34 70.25 1149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37145 BF_2 162.85 0.90 7885 642939202 XP_008200380.1 3391 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 462373300 APGK01024795.1 95 5.5653e-39 Dendroctonus ponderosae Seq01024805, whole genome shotgun sequence -- -- -- -- B3MFV7 1288 9.4e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF01825//PF02793//PF00002//PF02617//PF02140 Membrane transport protein//GPCR proteolysis site, GPS, motif//Hormone receptor domain//7 transmembrane receptor (Secretin family)//ATP-dependent Clp protease adaptor protein ClpS//Galactose binding lectin domain GO:0030163//GO:0055085//GO:0007186 protein catabolic process//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0030246 G-protein coupled receptor activity//carbohydrate binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.37147 BF_2 144.46 1.44 4473 291170320 ADD82416.1 712 8.0e-72 minus-C odorant binding protein 3 [Batocera horsfieldi] 291170319 GU584933.1 402 0 Batocera horsfieldi minus-C odorant binding protein 3 mRNA, complete cds -- -- -- -- -- -- -- -- PF01384//PF01484//PF01395 Phosphate transporter family//Nematode cuticle collagen N-terminal domain//PBP/GOBP family GO:0006817 phosphate ion transport GO:0005315//GO:0042302//GO:0005549 inorganic phosphate transmembrane transporter activity//structural constituent of cuticle//odorant binding GO:0016020 membrane -- -- Cluster-8309.37149 BF_2 3672.55 24.87 6465 91088689 XP_974981.1 866 1.6e-89 PREDICTED: protein phosphatase 1 regulatory subunit 7 [Tribolium castaneum] 332373161 BT126760.1 204 1.16423e-99 Dendroctonus ponderosae clone DPO1116_A05 unknown mRNA K17550 PPP1R7, SDS22 protein phosphatase 1 regulatory subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17550 Q5HZV9 606 9.3e-61 Protein phosphatase 1 regulatory subunit 7 OS=Rattus norvegicus GN=Ppp1r7 PE=1 SV=1 PF00560//PF00651//PF01287//PF13912//PF13855//PF00096 Leucine Rich Repeat//BTB/POZ domain//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//C2H2-type zinc finger//Leucine rich repeat//Zinc finger, C2H2 type GO:0006448//GO:0006452//GO:0045901//GO:0045905 regulation of translational elongation//translational frameshifting//positive regulation of translational elongation//positive regulation of translational termination GO:0005515//GO:0043022//GO:0003723//GO:0046872//GO:0003746 protein binding//ribosome binding//RNA binding//metal ion binding//translation elongation factor activity GO:0005840 ribosome KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.37150 BF_2 13341.00 433.01 1576 91088623 XP_976150.1 1185 4.0e-127 PREDICTED: voltage-dependent anion-selective channel-like [Tribolium castaneum] -- -- -- -- -- K15040 VDAC2 voltage-dependent anion channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15040 Q94920 1012 1.9e-108 Voltage-dependent anion-selective channel OS=Drosophila melanogaster GN=porin PE=1 SV=3 PF01459 Eukaryotic porin GO:0055085 transmembrane transport -- -- GO:0005741 mitochondrial outer membrane KOG3126 Porin/voltage-dependent anion-selective channel protein Cluster-8309.37152 BF_2 1020.47 34.80 1514 91087671 XP_976426.1 211 3.4e-14 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37155 BF_2 759.73 4.70 7045 270008875 EFA05323.1 4398 0.0e+00 hypothetical protein TcasGA2_TC015481 [Tribolium castaneum] 110431373 NM_001042570.1 994 0 Tribolium castaneum chitinase 7 (Cht7), mRNA >gnl|BL_ORD_ID|3159255 Tribolium castaneum chitinase 7 mRNA, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 1007 3.2e-107 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF01607//PF03123 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain//CAT RNA binding domain GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0003723//GO:0004553 chitin binding//RNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.37156 BF_2 532.99 2.75 8390 189236706 XP_974173.2 1532 1.2e-166 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 349 3.75621e-180 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 652 5.6e-66 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.37157 BF_2 3070.65 226.61 854 332375761 AEE63021.1 772 1.7e-79 unknown [Dendroctonus ponderosae] 835986266 XM_004969264.2 48 7.80024e-14 PREDICTED: Setaria italica malate dehydrogenase, mitochondrial-like (LOC101760979), mRNA K00026 MDH2 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00026 Q5NVR2 563 1.2e-56 Malate dehydrogenase, mitochondrial OS=Pongo abelii GN=MDH2 PE=2 SV=1 PF01073//PF02882//PF00056 3-beta hydroxysteroid dehydrogenase/isomerase family//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008209//GO:0006694//GO:0055114//GO:0008207//GO:0009396//GO:0046487//GO:0008210 androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//estrogen metabolic process GO:0016616//GO:0016491//GO:0004488//GO:0003824//GO:0003854 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1494 NAD-dependent malate dehydrogenase Cluster-8309.37158 BF_2 3058.78 18.13 7345 642930874 XP_008196120.1 1058 9.9e-112 PREDICTED: uncharacterized protein LOC658955 isoform X1 [Tribolium castaneum]>gi|642930876|ref|XP_008196121.1| PREDICTED: uncharacterized protein LOC658955 isoform X1 [Tribolium castaneum] 642930872 XM_965366.2 96 1.44089e-39 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 1.6e-16 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF05495//PF11808 CHY zinc finger//Domain of unknown function (DUF3329) GO:0016310 phosphorylation GO:0008270//GO:0004673 zinc ion binding//protein histidine kinase activity GO:0009365 protein histidine kinase complex -- -- Cluster-8309.37159 BF_2 10323.42 106.63 4337 642930308 XP_008196340.1 966 2.7e-101 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 1.3e-34 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF00439//PF03325 Bromodomain//Herpesvirus polymerase accessory protein GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0005515//GO:0030337 protein binding//DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.37161 BF_2 60.29 0.59 4589 642930308 XP_008196340.1 966 2.9e-101 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 1.4e-34 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF03325//PF00439 Herpesvirus polymerase accessory protein//Bromodomain GO:0019079//GO:0006260 viral genome replication//DNA replication GO:0005515//GO:0030337 protein binding//DNA polymerase processivity factor activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.37162 BF_2 448.00 8.56 2476 270005577 EFA02025.1 1263 5.7e-136 hypothetical protein TcasGA2_TC007650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U3W5 499 9.1e-49 Putative protein arginine N-methyltransferase 9 OS=Mus musculus GN=Prmt9 PE=2 SV=2 PF05185//PF13414//PF13374//PF13181//PF02390//PF05175 PRMT5 arginine-N-methyltransferase//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Putative methyltransferase//Methyltransferase small domain GO:0006400//GO:0008033//GO:0006479//GO:0009451 tRNA modification//tRNA processing//protein methylation//RNA modification GO:0005515//GO:0008168//GO:0008176 protein binding//methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.37163 BF_2 5100.47 64.66 3587 478252681 ENN73077.1 393 6.3e-35 hypothetical protein YQE_10281, partial [Dendroctonus ponderosae]>gi|546682841|gb|ERL92730.1| hypothetical protein D910_10040 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06859 Bicoid-interacting protein 3 (Bin3) -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.37165 BF_2 1671.05 15.12 4910 189238721 XP_970605.2 2529 1.8e-282 PREDICTED: collagen type IV alpha-3-binding protein isoform X1 [Tribolium castaneum]>gi|270010089|gb|EFA06537.1| hypothetical protein TcasGA2_TC009441 [Tribolium castaneum] 194753683 XM_001959104.1 36 2.17105e-06 Drosophila ananassae GF12210 (Dana\GF12210), mRNA K08283 COL4A3BP collagen type IV alpha-3-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08283 Q6VVX2 1509 1.4e-165 Collagen type IV alpha-3-binding protein OS=Cricetulus griseus GN=COL4A3BP PE=1 SV=1 PF08926//PF01852 Domain of unknown function (DUF1908)//START domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0008289//GO:0005543//GO:0000287//GO:0004674 ATP binding//lipid binding//phospholipid binding//magnesium ion binding//protein serine/threonine kinase activity -- -- KOG1737 Oxysterol-binding protein Cluster-8309.37166 BF_2 13.55 0.33 2021 307201205 EFN81111.1 925 7.2e-97 Tubulin beta-1 chain [Harpegnathos saltator] 164683615 EU373305.1 452 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 923 5.1e-98 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 PF04816//PF00091 tRNA (adenine(22)-N(1))-methyltransferase//Tubulin/FtsZ family, GTPase domain GO:0008033//GO:0009451 tRNA processing//RNA modification GO:0016429//GO:0003924 tRNA (adenine-N1-)-methyltransferase activity//GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.37167 BF_2 1572.10 13.24 5253 642928927 XP_008195620.1 2161 8.9e-240 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 263 1.50522e-132 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 512 6.0e-50 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37168 BF_2 496.30 4.17 5266 642928927 XP_008195620.1 2199 3.5e-244 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 282 4.13657e-143 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 559 2.1e-55 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37169 BF_2 60.90 0.99 2864 91092022 XP_970951.1 743 1.3e-75 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 629 8.9e-64 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37170 BF_2 5308.45 111.77 2274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00724 NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.37172 BF_2 3675.07 33.66 4855 546686533 ERL95731.1 499 4.3e-47 hypothetical protein D910_00173, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37173 BF_2 7540.57 94.08 3640 332375456 AEE62869.1 2168 9.6e-241 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 149 2.45028e-69 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 1815 3.4e-201 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF03328//PF00224//PF00478 HpcH/HpaI aldolase/citrate lyase family//Pyruvate kinase, barrel domain//IMP dehydrogenase / GMP reductase domain GO:0006096//GO:0006144//GO:0015976//GO:0006094//GO:0055114 glycolytic process//purine nucleobase metabolic process//carbon utilization//gluconeogenesis//oxidation-reduction process GO:0030955//GO:0003824//GO:0004743//GO:0000287 potassium ion binding//catalytic activity//pyruvate kinase activity//magnesium ion binding -- -- KOG2323 Pyruvate kinase Cluster-8309.37174 BF_2 3531.00 208.97 994 478251126 ENN71602.1 215 7.6e-15 hypothetical protein YQE_11701, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15798 Proline-rich AKT1 substrate 1 GO:0032007//GO:0048011 negative regulation of TOR signaling//neurotrophin TRK receptor signaling pathway -- -- -- -- -- -- Cluster-8309.37175 BF_2 7340.30 251.72 1507 91092312 XP_969869.1 565 3.0e-55 PREDICTED: transcriptional regulator DEF1 [Tribolium castaneum]>gi|270015692|gb|EFA12140.1| hypothetical protein TcasGA2_TC002287 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37176 BF_2 619.73 8.37 3384 642922662 XP_008193267.1 705 3.9e-71 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 492 8.0e-48 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005488//GO:0005506//GO:0016491//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-8309.37177 BF_2 6885.69 33.64 8850 642934775 XP_008197803.1 5864 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.37178 BF_2 156.74 0.72 9452 270012222 EFA08670.1 2246 2.2e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 413 3.3e-38 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF01277//PF03376//PF07690//PF03007//PF04661//PF06974 Sugar (and other) transporter//Oleosin//Adenovirus E3B protein//Major Facilitator Superfamily//Wax ester synthase-like Acyl-CoA acyltransferase domain//Poxvirus I3 ssDNA-binding protein//Protein of unknown function (DUF1298) GO:0045017//GO:0055085//GO:0042967//GO:0046486 glycerolipid biosynthetic process//transmembrane transport//acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0003697//GO:0022857//GO:0004144 single-stranded DNA binding//transmembrane transporter activity//diacylglycerol O-acyltransferase activity GO:0016021//GO:0012511//GO:0016020 integral component of membrane//monolayer-surrounded lipid storage body//membrane KOG2504 Monocarboxylate transporter Cluster-8309.37180 BF_2 1213.61 10.62 5068 642911420 XP_008199415.1 4264 0.0e+00 PREDICTED: insulin-like receptor [Tribolium castaneum]>gi|642911422|ref|XP_008199416.1| PREDICTED: insulin-like receptor [Tribolium castaneum] 887513390 KP331063.1 128 1.61439e-57 Leptinotarsa decemlineata insulin-like receptor (INR) mRNA, complete cds K04527 INSR insulin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04527 Q93105 2776 1.6e-312 Insulin-like receptor OS=Aedes aegypti GN=InR PE=2 SV=2 PF00041//PF00757//PF07714//PF00069 Fibronectin type III domain//Furin-like cysteine rich region//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0004672//GO:0004714//GO:0005515 ATP binding//protein kinase activity//transmembrane receptor protein tyrosine kinase activity//protein binding GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.37181 BF_2 2808.00 28.20 4452 546679881 ERL90269.1 808 5.9e-83 hypothetical protein D910_07621, partial [Dendroctonus ponderosae] -- -- -- -- -- K11135 PINX1 Pin2-interacting protein X1 http://www.genome.jp/dbget-bin/www_bget?ko:K11135 Q9CZX5 396 1.4e-36 PIN2/TERF1-interacting telomerase inhibitor 1 OS=Mus musculus GN=Pinx1 PE=2 SV=2 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG2809 Telomerase elongation inhibitor/RNA maturation protein PINX1 Cluster-8309.37182 BF_2 41.86 3.11 850 478252680 ENN73076.1 298 1.5e-24 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37185 BF_2 2347.54 18.48 5602 255522809 NP_001157317.1 607 1.5e-59 longitudinals lacking isoform 8 [Tribolium castaneum] 255522808 NM_001163845.1 256 1.25026e-128 Tribolium castaneum longitudinals lacking (Lola), transcript variant 8, mRNA -- -- -- -- Q7KQZ4 155 1.6e-08 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF16622//PF13912//PF02892//PF01873//PF00096//PF01403//PF13465 zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger//Domain found in IF2B/IF5//Zinc finger, C2H2 type//Sema domain//Zinc-finger double domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003677//GO:0003743//GO:0046872//GO:0005515 DNA binding//translation initiation factor activity//metal ion binding//protein binding GO:0005840 ribosome -- -- Cluster-8309.37186 BF_2 12758.13 71.76 7724 642928117 XP_008200164.1 422 5.8e-38 PREDICTED: protein anoxia up-regulated isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37187 BF_2 24643.28 1051.03 1268 22758950 AAN05630.1 556 2.8e-54 diapause-associated transcript-2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37188 BF_2 532.32 7.22 3373 189239596 XP_967754.2 3165 0.0e+00 PREDICTED: BTB/POZ domain-containing protein KCTD3 [Tribolium castaneum]>gi|270010663|gb|EFA07111.1| hypothetical protein TcasGA2_TC010101 [Tribolium castaneum] 170042981 XM_001849132.1 155 1.04811e-72 Culex quinquefasciatus BTB/POZ domain-containing protein KCTD3, mRNA -- -- -- -- Q8BFX3 1646 1.2e-181 BTB/POZ domain-containing protein KCTD3 OS=Mus musculus GN=Kctd3 PE=2 SV=1 PF02214//PF00651//PF00400 BTB/POZ domain//BTB/POZ domain//WD domain, G-beta repeat GO:0051260 protein homooligomerization GO:0005515 protein binding -- -- KOG2714 SETA binding protein SB1 and related proteins, contain BTB/POZ domain Cluster-8309.37191 BF_2 5392.12 9.63 23711 642935064 XP_008199925.1 9089 0.0e+00 PREDICTED: nesprin-1 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 823 2.3e-85 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF14867//PF10541//PF00837//PF00435 Lantibiotic alpha//Nuclear envelope localisation domain//Iodothyronine deiodinase//Spectrin repeat GO:0055114//GO:0050830 oxidation-reduction process//defense response to Gram-positive bacterium GO:0005515//GO:0004800 protein binding//thyroxine 5'-deiodinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.37192 BF_2 2831.25 22.44 5564 642916747 XP_972619.2 2337 3.7e-260 PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916749|ref|XP_008192467.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916751|ref|XP_008192470.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04422 MAP3K13, LZK mitogen-activated protein kinase kinase kinase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K04422 Q12852 1037 8.4e-111 Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG4721 Serine/threonine protein kinase, contains leucine zipper domain Cluster-8309.37196 BF_2 28.45 0.74 1901 357629937 EHJ78408.1 210 5.5e-14 chemosensory protein [Danaus plexippus] -- -- -- -- -- -- -- -- -- Q9W1C9 148 3.5e-08 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01348//PF08093 Type II intron maturase//Magi 5 toxic peptide family GO:0006810//GO:0006397//GO:0009405 transport//mRNA processing//pathogenesis GO:0019871 sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.37197 BF_2 65.84 68.91 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37199 BF_2 228.76 3.42 3082 91088357 XP_971705.1 1268 1.9e-136 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|270011777|gb|EFA08225.1| hypothetical protein TcasGA2_TC005852 [Tribolium castaneum] -- -- -- -- -- K17232 DUOXA2 dual oxidase maturation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17232 Q6DDK3 364 5.1e-33 Dual oxidase maturation factor 1 OS=Xenopus laevis GN=duoxa1 PE=2 SV=1 PF10204//PF01283 Dual oxidase maturation factor//Ribosomal protein S26e GO:0006412//GO:0015031//GO:0042254 translation//protein transport//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005789//GO:0016021//GO:0005622//GO:0044425//GO:0005840 endoplasmic reticulum membrane//integral component of membrane//intracellular//membrane part//ribosome -- -- Cluster-8309.372 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37201 BF_2 780.08 14.35 2561 642935527 XP_973346.2 2214 3.1e-246 PREDICTED: phosphoacetylglucosamine mutase [Tribolium castaneum] 629692694 XM_007813448.1 35 4.0481e-06 Metarhizium acridum CQMa 102 N-acetylglucosamine-phosphate mutase partial mRNA K01836 E5.4.2.3 phosphoacetylglucosamine mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01836 O95394 1460 3.5e-160 Phosphoacetylglucosamine mutase OS=Homo sapiens GN=PGM3 PE=1 SV=1 PF02880//PF05698//PF00408//PF02879//PF02878 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Bacterial trigger factor protein (TF) C-terminus//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0005975//GO:0015031//GO:0006457//GO:0071704 carbohydrate metabolic process//protein transport//protein folding//organic substance metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG2537 Phosphoglucomutase/phosphomannomutase Cluster-8309.37202 BF_2 1222.00 16.11 3460 270009032 EFA05480.1 175 1.1e-09 hypothetical protein TcasGA2_TC015664 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00614 Phospholipase D Active site motif -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.37203 BF_2 404.03 1.70 10202 270010025 EFA06473.1 8604 0.0e+00 hypothetical protein TcasGA2_TC009358 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.54934e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01025//PF09141//PF01044//PF02174//PF01608 GrpE//Talin, middle domain//Vinculin family//PTB domain (IRS-1 type)//I/LWEQ domain GO:0007016//GO:0007165//GO:0006457//GO:0007155 cytoskeletal anchoring at plasma membrane//signal transduction//protein folding//cell adhesion GO:0003779//GO:0005158//GO:0042803//GO:0051087//GO:0005200//GO:0051015//GO:0000774 actin binding//insulin receptor binding//protein homodimerization activity//chaperone binding//structural constituent of cytoskeleton//actin filament binding//adenyl-nucleotide exchange factor activity GO:0005899//GO:0001726//GO:0005856//GO:0005925 insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.37204 BF_2 606.73 1.95 13280 642926407 XP_008191950.1 4421 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.21898e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.8e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF02376//PF02121//PF00529//PF05920//PF03325//PF03699//PF10541//PF00046 CUT domain//Phosphatidylinositol transfer protein//HlyD membrane-fusion protein of T1SS//Homeobox KN domain//Herpesvirus polymerase accessory protein//Uncharacterised protein family (UPF0182)//Nuclear envelope localisation domain//Homeobox domain GO:0006355//GO:0006260//GO:0006810//GO:0019079//GO:0055085 regulation of transcription, DNA-templated//DNA replication//transport//viral genome replication//transmembrane transport GO:0030337//GO:0003677 DNA polymerase processivity factor activity//DNA binding GO:0016020//GO:0005622//GO:0042575//GO:0016021 membrane//intracellular//DNA polymerase complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.37205 BF_2 358.13 3.31 4812 642927623 XP_008195338.1 1388 3.5e-150 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] 560970175 XM_006207391.1 80 7.38557e-31 PREDICTED: Vicugna pacos BTB (POZ) domain containing 3 (BTBD3), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 1014 3.4e-108 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF10501//PF00651 Ribosomal subunit 39S//BTB/POZ domain -- -- GO:0005515 protein binding GO:0005739 mitochondrion KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.37206 BF_2 338211.72 11310.97 1538 575503657 AHG97630.1 1863 9.4e-206 cytochrome oxidase subunit I, partial (mitochondrion) [Batocera horsfieldi] 575503656 KF737820.1 1285 0 Batocera horsfieldi voucher HNAU.PP 041 cytochrome oxidase subunit I gene, partial cds; mitochondrial K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00400 1640 2.8e-181 Cytochrome c oxidase subunit 1 OS=Drosophila yakuba GN=mt:CoI PE=3 SV=2 -- -- -- -- -- -- -- -- KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.37207 BF_2 1331.00 151.36 655 91076400 XP_969165.1 299 9.0e-25 PREDICTED: ATP synthase subunit e, mitochondrial [Tribolium castaneum]>gi|270002900|gb|EEZ99347.1| hypothetical protein TcasGA2_TC004872 [Tribolium castaneum] -- -- -- -- -- K02129 ATPeF0E, ATP5I F-type H+-transporting ATPase subunit e http://www.genome.jp/dbget-bin/www_bget?ko:K02129 Q00361 123 9.5e-06 ATP synthase subunit e, mitochondrial OS=Bos taurus GN=ATP5I PE=1 SV=2 PF05680 ATP synthase E chain GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG4326 Mitochondrial F1F0-ATP synthase, subunit e Cluster-8309.37208 BF_2 448.27 3.25 6064 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF02617//PF01599//PF04183//PF02207 ATP-dependent Clp protease adaptor protein ClpS//Ribosomal protein S27a//IucA / IucC family//Putative zinc finger in N-recognin (UBR box) GO:0019290//GO:0006826//GO:0042254//GO:0030163//GO:0016567//GO:0006412 siderophore biosynthetic process//iron ion transport//ribosome biogenesis//protein catabolic process//protein ubiquitination//translation GO:0008270//GO:0015343//GO:0003735//GO:0004842 zinc ion binding//siderophore transmembrane transporter activity//structural constituent of ribosome//ubiquitin-protein transferase activity GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.37209 BF_2 85.28 2.62 1650 91084843 XP_966905.1 1228 4.3e-132 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 851 9.2e-90 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01073//PF01118//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//Male sterility protein GO:0008210//GO:0008207//GO:0008209//GO:0006694//GO:0055114 estrogen metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0051287//GO:0080019//GO:0016620 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.37211 BF_2 127.00 6.39 1118 91090063 XP_969355.1 875 2.5e-91 PREDICTED: protein SCO1 homolog, mitochondrial [Tribolium castaneum] 874457784 XM_005013934.2 48 1.03115e-13 PREDICTED: Anas platyrhynchos protein SCO1 homolog, mitochondrial (LOC101790131), transcript variant X1, mRNA K07152 SCO1_2 protein SCO1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07152 O75880 630 2.6e-64 Protein SCO1 homolog, mitochondrial OS=Homo sapiens GN=SCO1 PE=1 SV=1 PF00578 AhpC/TSA family GO:0055114 oxidation-reduction process GO:0016209//GO:0016491 antioxidant activity//oxidoreductase activity -- -- KOG2792 Putative cytochrome C oxidase assembly protein Cluster-8309.37213 BF_2 7190.58 63.13 5052 642930574 XP_008198195.1 1554 2.1e-169 PREDICTED: excitatory amino acid transporter 3-like [Tribolium castaneum]>gi|270009376|gb|EFA05824.1| hypothetical protein TcasGA2_TC008606 [Tribolium castaneum] 527266023 XM_005151139.1 53 7.92309e-16 PREDICTED: Melopsittacus undulatus solute carrier family 1 (glutamate transporter), member 7 (LOC101873134), mRNA K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 P31597 940 1.4e-99 Excitatory amino acid transporter 3 OS=Oryctolagus cuniculus GN=SLC1A1 PE=2 SV=1 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.37214 BF_2 650.57 22.51 1496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37216 BF_2 57.24 0.70 3723 270014971 EFA11419.1 1641 1.3e-179 hypothetical protein TcasGA2_TC013596 [Tribolium castaneum] 290048170 GU396008.1 405 0 Helicoverpa armigera arginine kinase mRNA, complete cds K00934 E2.7.3.3 arginine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00934 P48610 1581 4.7e-174 Arginine kinase OS=Drosophila melanogaster GN=Argk PE=2 SV=2 PF02807//PF00217 ATP:guanido phosphotransferase, N-terminal domain//ATP:guanido phosphotransferase, C-terminal catalytic domain -- -- GO:0016301//GO:0016772 kinase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG3581 Creatine kinases Cluster-8309.37217 BF_2 3844.02 151.16 1351 642914157 XP_008201570.1 601 1.8e-59 PREDICTED: muscle-specific protein 20 isoform X1 [Tribolium castaneum] 780694807 XM_011702209.1 83 4.37543e-33 PREDICTED: Wasmannia auropunctata muscle-specific protein 20-like (LOC105457507), transcript variant X2, mRNA -- -- -- -- P14318 464 5.7e-45 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.37219 BF_2 4029.35 22.54 7765 642928117 XP_008200164.1 422 5.9e-38 PREDICTED: protein anoxia up-regulated isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37225 BF_2 24250.99 74.03 13990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00770//PF05493 Adenovirus endoprotease//ATP synthase subunit H GO:0015992//GO:0015991//GO:0006508 proton transport//ATP hydrolysis coupled proton transport//proteolysis GO:0004197//GO:0015078 cysteine-type endopeptidase activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.37226 BF_2 2.00 2.25 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37227 BF_2 3223.22 43.69 3373 270011110 EFA07558.1 1126 5.9e-120 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 762 3.9e-79 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF02949//PF08367 Trypsin//7tm Odorant receptor//Peptidase M16C associated GO:0006508//GO:0007608//GO:0007187 proteolysis//sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0005549//GO:0004252//GO:0004984 odorant binding//serine-type endopeptidase activity//olfactory receptor activity GO:0016020 membrane -- -- Cluster-8309.37231 BF_2 135.85 1.11 5398 91083171 XP_972171.1 2439 5.3e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.8e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF15182//PF03919//PF00782//PF00102//PF01331 Otospiralin//mRNA capping enzyme, C-terminal domain//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//mRNA capping enzyme, catalytic domain GO:0035335//GO:0006370//GO:0006470//GO:0006570//GO:0007605//GO:0006397 peptidyl-tyrosine dephosphorylation//7-methylguanosine mRNA capping//protein dephosphorylation//tyrosine metabolic process//sensory perception of sound//mRNA processing GO:0004651//GO:0008138//GO:0004484//GO:0004725 polynucleotide 5'-phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//mRNA guanylyltransferase activity//protein tyrosine phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.37232 BF_2 119.11 3.28 1804 91083175 XP_972331.1 431 1.2e-39 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 323 1.7e-28 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.37233 BF_2 125.11 1.45 3908 642928913 XP_971104.2 1611 4.0e-176 PREDICTED: FK506-binding protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.37235 BF_2 479.98 7.29 3043 478250396 ENN70891.1 1074 5.7e-114 hypothetical protein YQE_12296, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8AWW5 248 1.4e-19 Cysteine-rich motor neuron 1 protein OS=Gallus gallus GN=CRIM1 PE=2 SV=1 PF00093//PF02822 von Willebrand factor type C domain//Antistasin family -- -- GO:0005515//GO:0004867 protein binding//serine-type endopeptidase inhibitor activity -- -- KOG1216 von Willebrand factor and related coagulation proteins Cluster-8309.37236 BF_2 48.59 1.05 2223 91081249 XP_975650.1 377 2.8e-33 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q80UU9 280 2.0e-23 Membrane-associated progesterone receptor component 2 OS=Mus musculus GN=Pgrmc2 PE=1 SV=2 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.37237 BF_2 294.00 5.14 2679 91084651 XP_967087.1 1472 3.6e-160 PREDICTED: leucine-rich repeat-containing protein 47 [Tribolium castaneum]>gi|270008920|gb|EFA05368.1| hypothetical protein TcasGA2_TC015534 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q505F5 744 3.8e-77 Leucine-rich repeat-containing protein 47 OS=Mus musculus GN=Lrrc47 PE=2 SV=1 PF03483//PF13855//PF00560 B3/4 domain//Leucine rich repeat//Leucine Rich Repeat GO:0006432//GO:0009094//GO:0006571//GO:0000162 phenylalanyl-tRNA aminoacylation//L-phenylalanine biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0003723//GO:0004826//GO:0005515 RNA binding//phenylalanine-tRNA ligase activity//protein binding GO:0009328 phenylalanine-tRNA ligase complex KOG0619 FOG: Leucine rich repeat Cluster-8309.37240 BF_2 4795.33 809.10 535 642926225 XP_008194836.1 502 2.1e-48 PREDICTED: 60S ribosomal protein L22 [Tribolium castaneum]>gi|270009023|gb|EFA05471.1| hypothetical protein TcasGA2_TC015654 [Tribolium castaneum] 762137041 XM_011453508.1 50 3.68416e-15 PREDICTED: Crassostrea gigas 60S ribosomal protein L22-like (LOC105345379), mRNA K02891 RP-L22e, RPL22 large subunit ribosomal protein L22e http://www.genome.jp/dbget-bin/www_bget?ko:K02891 Q98TF8 309 2.1e-27 60S ribosomal protein L22 OS=Gallus gallus GN=RPL22 PE=2 SV=1 PF01776 Ribosomal L22e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3434 60S ribosomal protein L22 Cluster-8309.37241 BF_2 129.47 3.56 1808 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37245 BF_2 1134.00 9.03 5541 134053892 NP_001076809.1 1502 2.5e-163 adipokinetic hormone receptor [Tribolium castaneum]>gi|642928766|ref|XP_008195552.1| PREDICTED: adipokinetic hormone receptor isoform X1 [Tribolium castaneum]>gi|90903321|gb|ABE02225.1| adipokinetic hormone receptor [Tribolium castaneum]>gi|126116536|gb|ABN79650.1| adipokinetic hormone receptor [Tribolium castaneum]>gi|270011068|gb|EFA07516.1| hypothetical protein TcasGA2_TC009772, partial [Tribolium castaneum] -- -- -- -- -- K04280 GNRHR gonadotropin-releasing hormone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04280 O42329 567 2.6e-56 Gonadotropin-releasing hormone II receptor OS=Clarias gariepinus PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0097211//GO:0007187//GO:0007186 cellular response to gonadotropin-releasing hormone//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//G-protein coupled receptor signaling pathway GO:0004968//GO:0004930 gonadotropin-releasing hormone receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.37246 BF_2 63.46 1.15 2605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37247 BF_2 23.83 0.96 1325 91085253 XP_973335.1 929 1.6e-97 PREDICTED: uncharacterized protein LOC662125 [Tribolium castaneum]>gi|270009097|gb|EFA05545.1| hypothetical protein TcasGA2_TC015733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00584 SecE/Sec61-gamma subunits of protein translocation complex GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0016020 membrane -- -- Cluster-8309.37249 BF_2 264.38 1.83 6325 642928815 XP_967995.2 1339 2.2e-144 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 7.3e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.3725 BF_2 4.00 0.32 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37251 BF_2 254.10 2.51 4514 642922337 XP_008193118.1 1681 3.5e-184 PREDICTED: four and a half LIM domains protein 2 isoform X4 [Tribolium castaneum] 642922336 XM_008194896.1 488 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X4, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 1.0e-106 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF07562//PF00412 Nine Cysteines Domain of family 3 GPCR//LIM domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.37254 BF_2 401.16 4.28 4212 166851824 NP_001107778.1 772 8.3e-79 cuticular protein analogous to peritrophins 3-C5 isoform 2 precursor [Tribolium castaneum]>gi|119387890|gb|ABL73930.1| obstractor C2 [Tribolium castaneum] 817185116 XM_012429676.1 188 5.93213e-91 PREDICTED: Orussus abietinus uncharacterized LOC105702248 (LOC105702248), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.37255 BF_2 2484.64 36.02 3173 121583754 NP_001073569.1 1223 3.2e-131 cuticular protein analogous to peritrophins 3-C5 isoform 1 precursor [Tribolium castaneum]>gi|119387888|gb|ABL73929.1| obstractor C1 [Tribolium castaneum] 121583753 NM_001080100.1 324 1.11425e-166 Tribolium castaneum cuticular protein analogous to peritrophins 3-C5 (Cpap3-c5), transcript variant 1, mRNA >gnl|BL_ORD_ID|3647361 Tribolium castaneum obstractor C1 (Obst-C1) mRNA, complete cds -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.37256 BF_2 7938.30 156.06 2415 332372937 AEE61610.1 1260 1.2e-135 unknown [Dendroctonus ponderosae]>gi|546684868|gb|ERL94450.1| hypothetical protein D910_11727 [Dendroctonus ponderosae] 758277713 KP113812.1 111 2.15391e-48 Acraea encedon voucher fj55_3 cytosolic malate dehydrogenase (Cmdh) gene, partial cds K00025 MDH1 malate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00025 Q5ZME2 1033 1.1e-110 Malate dehydrogenase, cytoplasmic OS=Gallus gallus GN=MDH1 PE=2 SV=1 PF02866//PF00056 lactate/malate dehydrogenase, alpha/beta C-terminal domain//lactate/malate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016616//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1496 Malate dehydrogenase Cluster-8309.37257 BF_2 2977.92 8.96 14187 189233641 XP_001814986.1 2409 4.2e-268 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 242018850 XM_002429839.1 113 9.89329e-49 Pediculus humanus corporis nicotinate phosphoribosyltransferase, putative, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2054 2.5e-228 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF01213//PF02892//PF13912//PF08603//PF02749//PF13465//PF07776//PF00096 Adenylate cyclase associated (CAP) N terminal//BED zinc finger//C2H2-type zinc finger//Adenylate cyclase associated (CAP) C terminal//Quinolinate phosphoribosyl transferase, N-terminal domain//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type GO:0007010 cytoskeleton organization GO:0046872//GO:0003779//GO:0016763//GO:0003677//GO:0008270 metal ion binding//actin binding//transferase activity, transferring pentosyl groups//DNA binding//zinc ion binding GO:0005634 nucleus KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.37259 BF_2 355.84 10.60 1691 642914581 XP_008190273.1 1541 2.2e-168 PREDICTED: uncharacterized protein LOC660922 isoform X1 [Tribolium castaneum] 642914580 XM_008192051.1 299 4.64609e-153 PREDICTED: Tribolium castaneum uncharacterized LOC660922 (LOC660922), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37260 BF_2 3004.83 75.05 1962 478251900 ENN72338.1 2250 1.6e-250 hypothetical protein YQE_10973, partial [Dendroctonus ponderosae]>gi|546680877|gb|ERL91063.1| hypothetical protein D910_08405 [Dendroctonus ponderosae] 170071688 XM_001869946.1 223 9.57361e-111 Culex quinquefasciatus dihydrolipoamide dehydrogenase, mRNA K00382 DLD, lpd, pdhD dihydrolipoamide dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00382 P09623 1847 3.5e-205 Dihydrolipoyl dehydrogenase, mitochondrial OS=Sus scrofa GN=DLD PE=1 SV=1 PF01494//PF07992//PF02852//PF12831//PF05834//PF01266//PF01134//PF00070//PF03721 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain//FAD dependent oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GO:0016117//GO:0045454//GO:0055114//GO:0008033 carotenoid biosynthetic process//cell redox homeostasis//oxidation-reduction process//tRNA processing GO:0016705//GO:0071949//GO:0016616//GO:0051287//GO:0016491//GO:0050660 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity//flavin adenine dinucleotide binding -- -- KOG1335 Dihydrolipoamide dehydrogenase Cluster-8309.37262 BF_2 41.13 0.37 4950 91094029 XP_967706.1 1178 8.1e-126 PREDICTED: mitochondrial inner membrane protein COX18 [Tribolium castaneum] -- -- -- -- -- K17797 COX18 mitochondrial inner membrane protein COX18 http://www.genome.jp/dbget-bin/www_bget?ko:K17797 Q8VC74 650 5.6e-66 Mitochondrial inner membrane protein COX18 OS=Mus musculus GN=Cox18 PE=2 SV=5 PF02096//PF00651 60Kd inner membrane protein//BTB/POZ domain GO:0051205 protein insertion into membrane GO:0005515 protein binding GO:0016021 integral component of membrane KOG1239 Inner membrane protein translocase involved in respiratory chain assembly Cluster-8309.37267 BF_2 1073.66 22.87 2251 91089533 XP_971109.1 674 1.0e-67 PREDICTED: synaptogyrin-1 [Tribolium castaneum]>gi|270011384|gb|EFA07832.1| hypothetical protein TcasGA2_TC005401 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43760 261 3.3e-21 Synaptogyrin-2 OS=Homo sapiens GN=SYNGR2 PE=1 SV=1 PF01529//PF01484//PF01284 DHHC palmitoyltransferase//Nematode cuticle collagen N-terminal domain//Membrane-associating domain -- -- GO:0008270//GO:0042302 zinc ion binding//structural constituent of cuticle GO:0016020 membrane -- -- Cluster-8309.37268 BF_2 1486.79 82.29 1043 91094039 XP_968178.1 740 1.1e-75 PREDICTED: cofilin/actin-depolymerizing factor homolog [Tribolium castaneum]>gi|270003140|gb|EEZ99587.1| hypothetical protein TcasGA2_TC001574 [Tribolium castaneum] 642915784 XM_963085.2 240 1.77817e-120 PREDICTED: Tribolium castaneum cofilin/actin-depolymerizing factor homolog (LOC656560), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 673 2.5e-69 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1735 Actin depolymerizing factor Cluster-8309.3727 BF_2 2.00 0.37 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37270 BF_2 160.00 3.89 2008 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37271 BF_2 67.52 0.33 8928 642934775 XP_008197803.1 5864 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.37272 BF_2 386.08 11.52 1689 642915492 XP_008190639.1 1194 3.9e-128 PREDICTED: glycerol kinase [Tribolium castaneum]>gi|642915494|ref|XP_008190640.1| PREDICTED: glycerol kinase [Tribolium castaneum]>gi|270003860|gb|EFA00308.1| hypothetical protein TcasGA2_TC003143 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q63060 786 3.3e-82 Glycerol kinase OS=Rattus norvegicus GN=Gk PE=2 SV=1 PF00370 FGGY family of carbohydrate kinases, N-terminal domain GO:0006072//GO:0046486//GO:0016310//GO:0005975 glycerol-3-phosphate metabolic process//glycerolipid metabolic process//phosphorylation//carbohydrate metabolic process GO:0004370//GO:0016773 glycerol kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.37273 BF_2 1065.65 142.94 599 91079048 XP_975100.1 564 1.5e-55 PREDICTED: myophilin [Tribolium castaneum]>gi|270003661|gb|EFA00109.1| hypothetical protein TcasGA2_TC002925 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P14318 281 4.2e-24 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.37274 BF_2 150.10 2.56 2741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965//PF15048 dsRNA-gated channel SID-1//Organic solute transporter subunit beta protein GO:0015931//GO:0006810//GO:0015721//GO:0033227 nucleobase-containing compound transport//transport//bile acid and bile salt transport//dsRNA transport GO:0046982//GO:0005215//GO:0051033 protein heterodimerization activity//transporter activity//RNA transmembrane transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.37275 BF_2 740.15 7.80 4259 642921997 XP_008192975.1 1073 1.0e-113 PREDICTED: calcium uniporter protein, mitochondrial [Tribolium castaneum] 884952751 XM_013134023.1 63 1.84157e-21 PREDICTED: Esox lucius mitochondrial calcium uniporter (mcu), transcript variant X2, mRNA -- -- -- -- Q08BI9 672 1.4e-68 Calcium uniporter protein, mitochondrial OS=Danio rerio GN=mcu PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2966 Uncharacterized conserved protein Cluster-8309.37277 BF_2 1298.71 26.40 2345 189241306 XP_975247.2 1469 7.0e-160 PREDICTED: protein croquemort-like [Tribolium castaneum]>gi|642936188|ref|XP_008198333.1| PREDICTED: protein croquemort-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 645 1.0e-65 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF06209//PF01130 Cofactor of BRCA1 (COBRA1)//CD36 family GO:0045892//GO:0007155 negative regulation of transcription, DNA-templated//cell adhesion -- -- GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.37279 BF_2 517.12 5.27 4391 91093203 XP_969368.1 999 4.1e-105 PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|642938151|ref|XP_008199786.1| PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|270016483|gb|EFA12929.1| hypothetical protein TcasGA2_TC010475 [Tribolium castaneum] 170043832 XM_001849523.1 373 0 Culex quinquefasciatus hippocalcin, mRNA -- -- -- -- P42325 984 9.3e-105 Neurocalcin homolog OS=Drosophila melanogaster GN=Nca PE=1 SV=2 PF13202//PF00036//PF11095//PF12763//PF13499//PF02745//PF10591//PF13833//PF13405 EF hand//EF hand//Gem-associated protein 7 (Gemin7)//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Methyl-coenzyme M reductase alpha subunit, N-terminal domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0007165//GO:0015948//GO:0046656 signal transduction//methanogenesis//folic acid biosynthetic process GO:0005509//GO:0050524//GO:0005515 calcium ion binding//coenzyme-B sulfoethylthiotransferase activity//protein binding GO:0005578//GO:0032797 proteinaceous extracellular matrix//SMN complex KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.37280 BF_2 5358.42 24.78 9332 270010611 EFA07059.1 1520 3.4e-165 hypothetical protein TcasGA2_TC010036 [Tribolium castaneum] 189239538 XM_970519.2 321 1.53557e-164 PREDICTED: Tribolium castaneum ras-related protein Rab-23 (LOC664521), mRNA K06234 RAB23 Ras-related protein Rab-23 http://www.genome.jp/dbget-bin/www_bget?ko:K06234 Q9ULC3 565 7.6e-56 Ras-related protein Rab-23 OS=Homo sapiens GN=RAB23 PE=1 SV=1 PF08477//PF00735//PF01926//PF12106//PF00025//PF02421//PF03193//PF04670//PF00071//PF10662 Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//Colicin C terminal ribonuclease domain//ADP-ribosylation factor family//Ferrous iron transport protein B//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation GO:0006576//GO:0007264//GO:0015684//GO:0051252 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport//regulation of RNA metabolic process GO:0005524//GO:0015093//GO:0004540//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//ribonuclease activity//GTPase activity//GTP binding GO:0016021 integral component of membrane KOG0079 GTP-binding protein H-ray, small G protein superfamily Cluster-8309.37283 BF_2 706.36 6.44 4875 546675851 ERL86956.1 2118 8.0e-235 hypothetical protein D910_04359 [Dendroctonus ponderosae] 676491074 XM_009067230.1 96 9.54387e-40 Lottia gigantea hypothetical protein mRNA K12179 COPS6, CSN6 COP9 signalosome complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12179 Q9VCY3 1146 1.7e-123 COP9 signalosome complex subunit 6 OS=Drosophila melanogaster GN=CSN6 PE=1 SV=1 PF00848//PF01398//PF05028 Ring hydroxylating alpha subunit (catalytic domain)//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Poly (ADP-ribose) glycohydrolase (PARG) GO:0019439//GO:0055114//GO:0005975 aromatic compound catabolic process//oxidation-reduction process//carbohydrate metabolic process GO:0005515//GO:0051537//GO:0004649//GO:0005506//GO:0016708 protein binding//2 iron, 2 sulfur cluster binding//poly(ADP-ribose) glycohydrolase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor -- -- KOG3050 COP9 signalosome, subunit CSN6 Cluster-8309.37285 BF_2 1745.76 12.44 6159 642923353 XP_008193715.1 2686 1.4e-300 PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q80VJ4 958 1.3e-101 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Rattus norvegicus GN=Gpcpd1 PE=2 SV=1 PF00686//PF03009 Starch binding domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0008081//GO:2001070 phosphoric diester hydrolase activity//starch binding -- -- KOG2421 Predicted starch-binding protein Cluster-8309.37288 BF_2 970.40 3.70 11262 642933099 XP_973043.3 3459 0.0e+00 PREDICTED: protein Gawky isoform X2 [Tribolium castaneum] 642933096 XM_008199035.1 385 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X2, mRNA K18412 TNRC6, GW182 trinucleotide repeat-containing gene 6 protein http://www.genome.jp/dbget-bin/www_bget?ko:K18412 Q5ZL26 1288 1.3e-139 Phosphoribosyl pyrophosphate synthase-associated protein 2 OS=Gallus gallus GN=PRPSAP2 PE=2 SV=1 PF00156//PF14572//PF00076//PF08587 Phosphoribosyl transferase domain//Phosphoribosyl synthetase-associated domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Ubiquitin associated domain (UBA) GO:0009116//GO:0006098//GO:0016310//GO:0009165//GO:0006144//GO:0009069 nucleoside metabolic process//pentose-phosphate shunt//phosphorylation//nucleotide biosynthetic process//purine nucleobase metabolic process//serine family amino acid metabolic process GO:0003676//GO:0004674//GO:0000287//GO:0004749 nucleic acid binding//protein serine/threonine kinase activity//magnesium ion binding//ribose phosphate diphosphokinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.37289 BF_2 1451.46 5.07 12253 91092426 XP_968165.1 6155 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC1 [Tribolium castaneum]>gi|270004743|gb|EFA01191.1| hypothetical protein TcasGA2_TC010518 [Tribolium castaneum] 617460781 XM_007571860.1 414 0 PREDICTED: Poecilia formosa ATP-binding cassette, sub-family E (OABP), member 1 (abce1), mRNA K03018 RPC1, POLR3A DNA-directed RNA polymerase III subunit RPC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03018 Q5ZL98 4386 0.0e+00 DNA-directed RNA polymerase III subunit RPC1 OS=Gallus gallus GN=POLR3A PE=2 SV=1 PF00004//PF05000//PF04983//PF08477//PF07728//PF13304//PF00931//PF04998//PF00623//PF02367//PF04997//PF06810//PF01920//PF00448//PF07352//PF07851//PF00910//PF03193//PF00005 ATPase family associated with various cellular activities (AAA)//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 3//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//AAA domain, putative AbiEii toxin, Type IV TA system//NB-ARC domain//RNA polymerase Rpb1, domain 5//RNA polymerase Rpb1, domain 2//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA polymerase Rpb1, domain 1//Phage minor structural protein GP20//Prefoldin subunit//SRP54-type protein, GTPase domain//Bacteriophage Mu Gam like protein//TMPIT-like protein//RNA helicase//Protein of unknown function, DUF258//ABC transporter GO:0006614//GO:0006457//GO:0042262//GO:0006351//GO:0006144//GO:0006206//GO:0002949//GO:0007264 SRP-dependent cotranslational protein targeting to membrane//protein folding//DNA protection//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0003899//GO:0005524//GO:0003924//GO:0005198//GO:0016887//GO:0051082//GO:0008270//GO:0003677//GO:0003723//GO:0043531//GO:0032549//GO:0005525//GO:0003724//GO:0003690 DNA-directed RNA polymerase activity//ATP binding//GTPase activity//structural molecule activity//ATPase activity//unfolded protein binding//zinc ion binding//DNA binding//RNA binding//ADP binding//ribonucleoside binding//GTP binding//RNA helicase activity//double-stranded DNA binding GO:0016021//GO:0005730//GO:0016272//GO:0005634 integral component of membrane//nucleolus//prefoldin complex//nucleus KOG0261 RNA polymerase III, large subunit Cluster-8309.37290 BF_2 325.85 8.01 1989 642923254 XP_008193679.1 749 1.8e-76 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.2e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF03796//PF00154 DnaB-like helicase C terminal domain//recA bacterial DNA recombination protein GO:0009432//GO:0006260//GO:0006281 SOS response//DNA replication//DNA repair GO:0005524//GO:0003678//GO:0003697 ATP binding//DNA helicase activity//single-stranded DNA binding GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.37291 BF_2 28.40 0.78 1805 478250804 ENN71296.1 582 3.8e-57 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10976 ERO1LB ERO1-like protein beta http://www.genome.jp/dbget-bin/www_bget?ko:K10976 Q9V3A6 419 1.3e-39 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137//PF02251 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//Proteasome activator pa28 alpha subunit GO:0055114 oxidation-reduction process GO:0003756//GO:0016671 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0005783//GO:0008537 endoplasmic reticulum//proteasome activator complex KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.37293 BF_2 23.89 0.31 3503 270011456 EFA07904.1 2261 1.5e-251 hypothetical protein TcasGA2_TC005479 [Tribolium castaneum] 642933027 XM_965305.2 396 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X1, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 1858 3.3e-206 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.37295 BF_2 836.14 34.36 1305 189238710 XP_969341.2 1871 9.4e-207 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 662207554 XM_008479062.1 42 2.61423e-10 PREDICTED: Diaphorina citri trichohyalin-like (LOC103514197), mRNA -- -- -- -- Q9JM99 220 1.1e-16 Proteoglycan 4 OS=Mus musculus GN=Prg4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37296 BF_2 746.00 6.67 4966 189234232 XP_973217.2 2793 0.0e+00 PREDICTED: serine/threonine-protein kinase Warts [Tribolium castaneum]>gi|270002603|gb|EEZ99050.1| hypothetical protein TcasGA2_TC004924 [Tribolium castaneum] 815821612 XM_012376640.1 417 0 PREDICTED: Linepithema humile serine/threonine-protein kinase Warts (LOC105677787), mRNA K08791 LATS1_2, Wts serine/threonine-protein kinase LATS1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08791 Q9VA38 1722 2.8e-190 Serine/threonine-protein kinase Warts OS=Drosophila melanogaster GN=wts PE=1 SV=1 PF03152//PF00069//PF06293//PF07714 Ubiquitin fusion degradation protein UFD1//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006511//GO:0006468//GO:0016310 ubiquitin-dependent protein catabolic process//protein phosphorylation//phosphorylation GO:0000166//GO:0016773//GO:0004672//GO:0005524 nucleotide binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding GO:0016020 membrane KOG0605 NDR and related serine/threonine kinases Cluster-8309.37297 BF_2 3830.00 12.02 13616 546673612 ERL85176.1 9589 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911102 XM_008202356.1 2856 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X6, mRNA -- -- -- -- Q23551 4808 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF02480//PF01344//PF16794//PF01891//PF15170//PF16656//PF01300//PF00041//PF13895//PF01108 Alphaherpesvirus glycoprotein E//Kelch motif//Fibronectin-III type domain//Cobalt uptake substrate-specific transmembrane region//Calcium/calmodulin-dependent protein kinase II inhibitor//Purple acid Phosphatase, N-terminal domain//Telomere recombination//Fibronectin type III domain//Immunoglobulin domain//Tissue factor GO:0006771//GO:0000041//GO:0019497//GO:0045859 riboflavin metabolic process//transition metal ion transport//hexachlorocyclohexane metabolic process//regulation of protein kinase activity GO:0046872//GO:0003725//GO:0003993//GO:0005515//GO:0004860 metal ion binding//double-stranded RNA binding//acid phosphatase activity//protein binding//protein kinase inhibitor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37298 BF_2 253.42 6.52 1913 332375618 AEE62950.1 1358 4.2e-147 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02175 BRN putative enzyme (brainiac) http://www.genome.jp/dbget-bin/www_bget?ko:K02175 Q24157 635 1.2e-64 Beta-1,3-galactosyltransferase brn OS=Drosophila melanogaster GN=brn PE=2 SV=2 PF05557//PF02434//PF01762 Mitotic checkpoint protein//Fringe-like//Galactosyltransferase GO:0006486//GO:0007094 protein glycosylation//mitotic spindle assembly checkpoint GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.37300 BF_2 1282.94 32.45 1941 91089929 XP_973045.1 203 3.6e-13 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37301 BF_2 882.06 4.49 8510 270012359 EFA08807.1 1919 1.7e-211 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.3e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF08783//PF02817//PF04564//PF00098//PF14634//PF01588//PF00097//PF13639//PF00198 DWNN domain//e3 binding domain//U-box domain//Zinc knuckle//zinc-RING finger domain//Putative tRNA binding domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain) GO:0016567//GO:0008152 protein ubiquitination//metabolic process GO:0004842//GO:0016746//GO:0005515//GO:0000049//GO:0046872//GO:0008270//GO:0003676 ubiquitin-protein transferase activity//transferase activity, transferring acyl groups//protein binding//tRNA binding//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.37307 BF_2 733.00 216.76 428 350646286 CCD59012.1 288 1.1e-23 saposin containing protein [Schistosoma mansoni] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37308 BF_2 3196.88 16.80 8248 642931063 XP_008196196.1 1688 9.9e-185 PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|642931065|ref|XP_008196197.1| PREDICTED: uncharacterized protein LOC103313795 [Tribolium castaneum]>gi|270011892|gb|EFA08340.1| hypothetical protein TcasGA2_TC005983 [Tribolium castaneum] 195484142 XM_002090535.1 90 3.50437e-36 Drosophila yakuba RpS26 (Dyak\RpS26), partial mRNA K02976 RP-S26e, RPS26 small subunit ribosomal protein S26e http://www.genome.jp/dbget-bin/www_bget?ko:K02976 Q9GT45 503 1.0e-48 40S ribosomal protein S26 OS=Anopheles gambiae GN=RpS26 PE=3 SV=2 PF06156//PF04977//PF15473//PF13851//PF01283 Protein of unknown function (DUF972)//Septum formation initiator//PEST, proteolytic signal-containing nuclear protein family//Growth-arrest specific micro-tubule binding//Ribosomal protein S26e GO:0042254//GO:0007049//GO:0006260//GO:0016567//GO:0048870//GO:0006412 ribosome biogenesis//cell cycle//DNA replication//protein ubiquitination//cell motility//translation GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0031514 intracellular//ribosome//motile cilium KOG1768 40s ribosomal protein S26 Cluster-8309.37309 BF_2 538.34 4.51 5276 642918013 XP_008198979.1 1028 2.1e-108 PREDICTED: cytochrome c1, heme protein, mitochondrial [Tribolium castaneum]>gi|270004913|gb|EFA01361.1| mitochondrial cytochrome c1 [Tribolium castaneum] -- -- -- -- -- K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 744 7.5e-77 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF00034//PF13442//PF02167 Cytochrome c//Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome C1 family GO:0006118 obsolete electron transport GO:0020037//GO:0005488//GO:0009055 heme binding//binding//electron carrier activity -- -- KOG3052 Cytochrome c1 Cluster-8309.37310 BF_2 647.86 13.77 2256 91095261 XP_973714.1 857 6.2e-89 PREDICTED: transmembrane emp24 domain-containing protein bai [Tribolium castaneum]>gi|642940176|ref|XP_008200551.1| PREDICTED: transmembrane emp24 domain-containing protein bai [Tribolium castaneum]>gi|270017048|gb|EFA13494.1| hypothetical protein TcasGA2_TC016304 [Tribolium castaneum] 346709726 AK385774.1 66 2.08239e-23 Bombyx mori mRNA, clone: fphe08C16 -- -- -- -- B4GE47 756 1.3e-78 Transmembrane emp24 domain-containing protein bai OS=Drosophila persimilis GN=bai PE=3 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1691 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.37311 BF_2 3939.25 39.39 4471 270014227 EFA10675.1 4152 0.0e+00 kinesin heavy chain [Tribolium castaneum] 642936643 XM_008200299.1 908 0 PREDICTED: Tribolium castaneum kinesin 1 (LOC662208), mRNA K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 3478 0.0e+00 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF08702//PF15461//PF01601//PF00225 Fibrinogen alpha/beta chain family//Beta-carotene 15,15'-dioxygenase//Coronavirus S2 glycoprotein//Kinesin motor domain GO:0061025//GO:0030168//GO:0046813//GO:0007017//GO:0055114//GO:0007018//GO:0007165//GO:0051258 membrane fusion//platelet activation//receptor-mediated virion attachment to host cell//microtubule-based process//oxidation-reduction process//microtubule-based movement//signal transduction//protein polymerization GO:0030674//GO:0008017//GO:0003777//GO:0005102//GO:0005524//GO:0016702 protein binding, bridging//microtubule binding//microtubule motor activity//receptor binding//ATP binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005874//GO:0019031//GO:0005577//GO:0016021//GO:0045298 microtubule//viral envelope//fibrinogen complex//integral component of membrane//tubulin complex KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.37312 BF_2 111.14 2.21 2387 731463707 XP_003407411.2 642 5.6e-64 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100675838 [Loxodonta africana] 642923856 XM_008195686.1 201 1.98319e-98 PREDICTED: Tribolium castaneum uncharacterized LOC663851 (LOC663851), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 603 7.6e-61 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13912//PF07776//PF13465//PF00096//PF01155//PF07975 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain GO:0006464//GO:0006281 cellular protein modification process//DNA repair GO:0008270//GO:0016151//GO:0046872 zinc ion binding//nickel cation binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.37313 BF_2 430.05 11.53 1847 91091570 XP_967396.1 2526 1.5e-282 PREDICTED: pre-mRNA-processing factor 17 [Tribolium castaneum]>gi|270001029|gb|EEZ97476.1| hypothetical protein TcasGA2_TC011310 [Tribolium castaneum] 801386190 XM_012201009.1 177 3.35437e-85 PREDICTED: Atta cephalotes pre-mRNA-processing factor 17 (LOC105619494), mRNA K12816 CDC40, PRP17 pre-mRNA-processing factor 17 http://www.genome.jp/dbget-bin/www_bget?ko:K12816 Q9DC48 1983 5.6e-221 Pre-mRNA-processing factor 17 OS=Mus musculus GN=Cdc40 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0282 mRNA splicing factor Cluster-8309.37314 BF_2 218.40 4.96 2129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02895 Signal transducing histidine kinase, homodimeric domain GO:0016310//GO:0000160//GO:0006935 phosphorylation//phosphorelay signal transduction system//chemotaxis GO:0000155//GO:0004673 phosphorelay sensor kinase activity//protein histidine kinase activity GO:0005737//GO:0009365 cytoplasm//protein histidine kinase complex -- -- Cluster-8309.37315 BF_2 65.53 1.06 2873 642922794 XP_008193328.1 2003 1.0e-221 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 5.2e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF11965//PF06905//PF08496//PF03357 Domain of unknown function (DUF3479)//Fas apoptotic inhibitory molecule (FAIM1)//Peptidase family S49 N-terminal//Snf7 GO:0043066//GO:0007034//GO:0015994 negative regulation of apoptotic process//vacuolar transport//chlorophyll metabolic process GO:0004252//GO:0016851 serine-type endopeptidase activity//magnesium chelatase activity GO:0010007//GO:0005886 magnesium chelatase complex//plasma membrane -- -- Cluster-8309.37316 BF_2 570.11 7.38 3519 642936430 XP_008198431.1 1296 1.2e-139 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X3 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.16588e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q6GPZ1 438 1.5e-41 RISC-loading complex subunit tarbp2 OS=Xenopus laevis GN=tarbp2 PE=2 SV=2 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.37317 BF_2 197.38 2.80 3236 859132811 AKO63319.1 3478 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2391 4.8e-268 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF02460//PF00487//PF00368 Patched family//Fatty acid desaturase//Hydroxymethylglutaryl-coenzyme A reductase GO:0007165//GO:0006629//GO:0015936//GO:0055114//GO:0006694 signal transduction//lipid metabolic process//coenzyme A metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0050662//GO:0008158//GO:0004420 coenzyme binding//hedgehog receptor activity//hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0016020 membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.37319 BF_2 1013.32 34.92 1501 665812915 XP_008554994.1 1196 2.0e-128 PREDICTED: uncharacterized protein LOC103576525 isoform X6 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P13678 128 5.8e-06 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF00168//PF09202 Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain//Rio2, N-terminal GO:0009069//GO:0035556//GO:0006468//GO:0016310 serine family amino acid metabolic process//intracellular signal transduction//protein phosphorylation//phosphorylation GO:0005515//GO:0004674//GO:0005524 protein binding//protein serine/threonine kinase activity//ATP binding -- -- -- -- Cluster-8309.3732 BF_2 2.24 0.37 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37322 BF_2 273.98 3.62 3454 642922794 XP_008193328.1 1299 5.3e-140 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 690 9.0e-71 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37324 BF_2 442.98 8.64 2431 91079832 XP_970236.1 693 6.9e-70 PREDICTED: protein enabled isoform X1 [Tribolium castaneum]>gi|270003288|gb|EEZ99735.1| hypothetical protein TcasGA2_TC002504 [Tribolium castaneum] 642918238 XM_008193203.1 203 1.56178e-99 PREDICTED: Tribolium castaneum protein enabled (LOC658784), transcript variant X2, mRNA K05746 ENAH, MENA enabled http://www.genome.jp/dbget-bin/www_bget?ko:K05746 Q8T4F7 462 1.7e-44 Protein enabled OS=Drosophila melanogaster GN=ena PE=1 SV=4 PF00638//PF12235 RanBP1 domain//Fragile X-related 1 protein core C terminal GO:0046907 intracellular transport GO:0003723 RNA binding -- -- KOG4590 Signal transduction protein Enabled, contains WH1 domain Cluster-8309.37325 BF_2 286.00 8.62 1675 642914789 XP_008190353.1 352 1.7e-30 PREDICTED: glutamic acid-rich protein [Tribolium castaneum]>gi|270002301|gb|EEZ98748.1| hypothetical protein TcasGA2_TC001306 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82970 153 8.1e-09 High mobility group nucleosome-binding domain-containing protein 5 OS=Homo sapiens GN=HMGN5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37326 BF_2 625.95 16.57 1867 478256018 ENN76217.1 2067 2.5e-229 hypothetical protein YQE_07184, partial [Dendroctonus ponderosae] 158295753 XM_001688807.1 230 1.16907e-114 Anopheles gambiae str. PEST AGAP006366-PD (AgaP_AGAP006366) mRNA, complete cds K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 1423 4.9e-156 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.37327 BF_2 10759.49 53.86 8644 642934775 XP_008197803.1 5053 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 2332 9.0e-261 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.37328 BF_2 403.04 8.23 2336 91087367 XP_975633.1 885 3.6e-92 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 341 1.8e-30 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37331 BF_2 2875.30 10.40 11853 91092426 XP_968165.1 5142 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC1 [Tribolium castaneum]>gi|270004743|gb|EFA01191.1| hypothetical protein TcasGA2_TC010518 [Tribolium castaneum] 617460781 XM_007571860.1 414 0 PREDICTED: Poecilia formosa ATP-binding cassette, sub-family E (OABP), member 1 (abce1), mRNA K03018 RPC1, POLR3A DNA-directed RNA polymerase III subunit RPC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03018 Q5ZL98 3717 0.0e+00 DNA-directed RNA polymerase III subunit RPC1 OS=Gallus gallus GN=POLR3A PE=2 SV=1 PF00005//PF03193//PF00910//PF07851//PF07352//PF00448//PF01084//PF01920//PF06810//PF04997//PF02367//PF00623//PF04998//PF00931//PF13304//PF07728//PF08477//PF04983//PF05000//PF00004 ABC transporter//Protein of unknown function, DUF258//RNA helicase//TMPIT-like protein//Bacteriophage Mu Gam like protein//SRP54-type protein, GTPase domain//Ribosomal protein S18//Prefoldin subunit//Phage minor structural protein GP20//RNA polymerase Rpb1, domain 1//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 5//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//ATPase family associated with various cellular activities (AAA) GO:0042254//GO:0006614//GO:0007264//GO:0006206//GO:0002949//GO:0006412//GO:0006144//GO:0006457//GO:0042262//GO:0006351 ribosome biogenesis//SRP-dependent cotranslational protein targeting to membrane//small GTPase mediated signal transduction//pyrimidine nucleobase metabolic process//tRNA threonylcarbamoyladenosine modification//translation//purine nucleobase metabolic process//protein folding//DNA protection//transcription, DNA-templated GO:0016887//GO:0008270//GO:0051082//GO:0003735//GO:0003924//GO:0005198//GO:0005524//GO:0003899//GO:0003724//GO:0003690//GO:0005525//GO:0043531//GO:0032549//GO:0003677//GO:0003723 ATPase activity//zinc ion binding//unfolded protein binding//structural constituent of ribosome//GTPase activity//structural molecule activity//ATP binding//DNA-directed RNA polymerase activity//RNA helicase activity//double-stranded DNA binding//GTP binding//ADP binding//ribonucleoside binding//DNA binding//RNA binding GO:0016272//GO:0005730//GO:0005622//GO:0005840//GO:0016021//GO:0005634 prefoldin complex//nucleolus//intracellular//ribosome//integral component of membrane//nucleus KOG0261 RNA polymerase III, large subunit Cluster-8309.37332 BF_2 1500.51 32.39 2225 332373744 AEE62013.1 291 2.6e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5EF78 135 1.3e-06 Icarapin OS=Apis mellifera carnica PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37333 BF_2 127.90 1.15 4935 91085983 XP_972029.1 1876 9.4e-207 PREDICTED: TBC1 domain family member 31 [Tribolium castaneum]>gi|270010179|gb|EFA06627.1| hypothetical protein TcasGA2_TC009546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DN5 1034 1.7e-110 TBC1 domain family member 31 OS=Homo sapiens GN=TBC1D31 PE=2 SV=2 PF03091//PF00156//PF03310//PF06689 CutA1 divalent ion tolerance protein//Phosphoribosyl transferase domain//Caulimovirus DNA-binding protein//ClpX C4-type zinc finger GO:0010038//GO:0009116 response to metal ion//nucleoside metabolic process GO:0046983//GO:0008270//GO:0003677 protein dimerization activity//zinc ion binding//DNA binding -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-8309.37334 BF_2 1020.53 5.51 8040 546673207 ERL84861.1 1263 1.8e-135 hypothetical protein D910_02283 [Dendroctonus ponderosae] -- -- -- -- -- K10277 KDM8, JMJD5 lysine-specific demethylase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10277 O77475 954 5.1e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF03824//PF03193//PF00005//PF15458//PF00503//PF17078//PF02183//PF04548//PF06156//PF06005//PF00437//PF00312//PF01066//PF05529 High-affinity nickel-transport protein//Protein of unknown function, DUF258//ABC transporter//Nineteen complex-related protein 2//G-protein alpha subunit//SWI5-dependent HO expression protein 3//Homeobox associated leucine zipper//AIG1 family//Protein of unknown function (DUF972)//Protein of unknown function (DUF904)//Type II/IV secretion system protein//Ribosomal protein S15//CDP-alcohol phosphatidyltransferase//B-cell receptor-associated protein 31-like GO:0006260//GO:0035444//GO:0042254//GO:0048309//GO:0051028//GO:0007186//GO:0000390//GO:0006355//GO:0015675//GO:0007165//GO:0006886//GO:0006810//GO:0008654//GO:0000917//GO:0043093//GO:0006412 DNA replication//nickel cation transmembrane transport//ribosome biogenesis//endoplasmic reticulum inheritance//mRNA transport//G-protein coupled receptor signaling pathway//spliceosomal complex disassembly//regulation of transcription, DNA-templated//nickel cation transport//signal transduction//intracellular protein transport//transport//phospholipid biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//translation GO:0016887//GO:0019001//GO:0003735//GO:0003700//GO:0031683//GO:0005524//GO:0003924//GO:0046872//GO:0043565//GO:0004871//GO:0015099//GO:0005525//GO:0016780 ATPase activity//guanyl nucleotide binding//structural constituent of ribosome//transcription factor activity, sequence-specific DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//metal ion binding//sequence-specific DNA binding//signal transducer activity//nickel cation transmembrane transporter activity//GTP binding//phosphotransferase activity, for other substituted phosphate groups GO:0071008//GO:0005667//GO:0005622//GO:0005840//GO:0005737//GO:0016021//GO:0016020//GO:0005783 U2-type post-mRNA release spliceosomal complex//transcription factor complex//intracellular//ribosome//cytoplasm//integral component of membrane//membrane//endoplasmic reticulum KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.37335 BF_2 44.50 1.21 1830 33112583 AAP94047.1 1363 1.1e-147 cathepsin-L-like cysteine peptidase 03 [Tenebrio molitor] 33112582 AY332271.1 234 6.8453e-117 Tenebrio molitor cathepsin-L-like cysteine peptidase 03 mRNA, complete cds K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 1201 2.7e-130 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37337 BF_2 6.00 0.64 679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37338 BF_2 54.60 0.87 2915 642915176 XP_008190506.1 292 2.6e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37340 BF_2 74.51 1.18 2926 642924318 XP_008194246.1 790 4.7e-81 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 264 1.9e-21 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 -- -- GO:0006811 ion transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.37341 BF_2 1567.87 12.70 5451 478254120 ENN74402.1 4180 0.0e+00 hypothetical protein YQE_08987, partial [Dendroctonus ponderosae] 156845530 XM_001645606.1 61 3.05464e-20 Vanderwaltozyma polyspora DSM 70294 hypothetical protein (Kpol_541p40) partial mRNA K12618 XRN1, SEP1, KEM1 5'-3' exoribonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12618 P97789 2893 0.0e+00 5'-3' exoribonuclease 1 OS=Mus musculus GN=Xrn1 PE=1 SV=1 PF03159 XRN 5'-3' exonuclease N-terminus -- -- GO:0004527//GO:0003676 exonuclease activity//nucleic acid binding -- -- KOG2045 5'-3' exonuclease XRN1/KEM1/SEP1 involved in DNA strand exchange and mRNA turnover Cluster-8309.37342 BF_2 1048.09 10.16 4604 91093150 XP_970085.1 3501 0.0e+00 PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X1 [Tribolium castaneum]>gi|270003008|gb|EEZ99455.1| hypothetical protein TcasGA2_TC000021 [Tribolium castaneum] 795078999 XM_012021559.1 166 1.10131e-78 PREDICTED: Vollenhovia emeryi ribosomal protein S6 kinase alpha-5 (LOC105567037), transcript variant X2, mRNA K04445 MSK1, RPS6KA5 ribosomal protein S6 kinase alpha-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04445 O75582 2215 1.8e-247 Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens GN=RPS6KA5 PE=1 SV=1 PF00433//PF07714//PF06293//PF00069 Protein kinase C terminal domain//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.37343 BF_2 882.69 3.46 10972 642922880 XP_008200435.1 6092 0.0e+00 PREDICTED: maestro heat-like repeat-containing protein family member 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDA8 1449 2.8e-158 Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 PF00628//PF01429//PF02985//PF05485//PF00096//PF07178//PF11698 PHD-finger//Methyl-CpG binding domain//HEAT repeat//THAP domain//Zinc finger, C2H2 type//TraL protein//V-ATPase subunit H GO:0000746//GO:0015991 conjugation//ATP hydrolysis coupled proton transport GO:0046872//GO:0003676//GO:0005515//GO:0016820//GO:0003677 metal ion binding//nucleic acid binding//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//DNA binding GO:0000221//GO:0019867//GO:0005634 vacuolar proton-transporting V-type ATPase, V1 domain//outer membrane//nucleus KOG2032 Uncharacterized conserved protein Cluster-8309.37344 BF_2 285.55 2.83 4503 189237587 XP_975066.2 695 7.5e-70 PREDICTED: nuclear cap-binding protein subunit 2 [Tribolium castaneum] 755860540 XM_005178495.2 76 1.15591e-28 PREDICTED: Musca domestica nuclear cap-binding protein subunit 2B (LOC101888112), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 629 1.4e-63 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.37345 BF_2 8324.42 442.01 1075 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37346 BF_2 164.03 1.05 6830 332376178 AEE63229.1 915 3.5e-95 unknown [Dendroctonus ponderosae] 642924593 XM_008196134.1 241 3.32536e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.3e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.37348 BF_2 469.20 3.20 6429 91081951 XP_967254.1 2000 5.1e-221 PREDICTED: LIM domain-containing protein jub isoform X2 [Tribolium castaneum]>gi|270007323|gb|EFA03771.1| hypothetical protein TcasGA2_TC013882 [Tribolium castaneum] 170045329 XM_001850215.1 286 3.02031e-145 Culex quinquefasciatus limd1, mRNA K16682 AJUBA, LIMD1, WTIP LIM domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K16682 Q9VY77 1200 1.2e-129 LIM domain-containing protein jub OS=Drosophila melanogaster GN=jub PE=1 SV=3 PF00412//PF00400 LIM domain//WD domain, G-beta repeat -- -- GO:0043169//GO:0008270//GO:0005515 cation binding//zinc ion binding//protein binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.37349 BF_2 81.02 0.88 4149 642929336 XP_008195791.1 1307 7.5e-141 PREDICTED: AMP deaminase 2 isoform X2 [Tribolium castaneum] 194769475 XM_001966794.1 279 1.51352e-141 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 968 6.3e-103 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0019239//GO:0016491//GO:0046872 deaminase activity//oxidoreductase activity//metal ion binding -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.37350 BF_2 1306.39 16.77 3546 642929336 XP_008195791.1 1885 6.1e-208 PREDICTED: AMP deaminase 2 isoform X2 [Tribolium castaneum] 194769475 XM_001966794.1 279 1.29162e-141 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q02356 1080 5.5e-116 AMP deaminase 2 OS=Rattus norvegicus GN=Ampd2 PE=2 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0019239//GO:0016491//GO:0046872 deaminase activity//oxidoreductase activity//metal ion binding -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.37354 BF_2 6.33 0.39 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37355 BF_2 4480.28 110.26 1987 91083175 XP_972331.1 1160 4.0e-124 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 785 5.0e-82 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 PF15182 Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.37359 BF_2 115.72 3.41 1706 22758950 AAN05630.1 535 1.0e-51 diapause-associated transcript-2 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00649 Copper fist DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005507//GO:0003677 transcription factor activity, sequence-specific DNA binding//copper ion binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.37360 BF_2 606.00 24.33 1329 546685306 ERL94833.1 584 1.6e-57 hypothetical protein D910_12106 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q64425 321 2.1e-28 Pancreatic triacylglycerol lipase (Fragment) OS=Myocastor coypus GN=PNLIP PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37361 BF_2 1159.00 39.30 1521 91088257 XP_966746.1 2123 6.6e-236 PREDICTED: 26S proteasome non-ATPase regulatory subunit 12 [Tribolium castaneum]>gi|270012153|gb|EFA08601.1| hypothetical protein TcasGA2_TC006260 [Tribolium castaneum] -- -- -- -- -- K03035 PSMD12, RPN5 26S proteasome regulatory subunit N5 http://www.genome.jp/dbget-bin/www_bget?ko:K03035 Q9D8W5 1509 4.3e-166 26S proteasome non-ATPase regulatory subunit 12 OS=Mus musculus GN=Psmd12 PE=1 SV=4 PF07988//PF01397//PF01399 LMSTEN motif//Terpene synthase, N-terminal domain//PCI domain GO:0006355//GO:0008152 regulation of transcription, DNA-templated//metabolic process GO:0005515//GO:0016829//GO:0010333 protein binding//lyase activity//terpene synthase activity -- -- KOG1498 26S proteasome regulatory complex, subunit RPN5/PSMD12 Cluster-8309.37362 BF_2 109693.00 4640.52 1276 556505470 YP_008757567.1 1591 2.7e-174 cytochrome b (mitochondrion) [Batocera lineolata]>gi|359294293|gb|AEV21662.1| cytochrome b [Batocera lineolata] 359294281 JN986793.1 882 0 Batocera lineolata mitochondrion, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 Q8WBV2 1285 3.4e-140 Cytochrome b OS=Ostrinia nubilalis GN=MT-CYB PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4663 Cytochrome b Cluster-8309.37364 BF_2 16550.38 337.42 2339 826467549 XP_012535467.1 2245 7.2e-250 PREDICTED: glutamate dehydrogenase, mitochondrial [Monomorium pharaonis] 817214513 XM_012428072.1 262 2.39164e-132 PREDICTED: Orussus abietinus glutamate dehydrogenase, mitochondrial (LOC105701373), mRNA K00261 GLUD1_2, gdhA glutamate dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00261 P54385 2080 4.0e-232 Glutamate dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=Gdh PE=1 SV=2 PF00208//PF02812//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0006520 oxidation-reduction process//cellular amino acid metabolic process GO:0051287//GO:0016491 NAD binding//oxidoreductase activity -- -- KOG2250 Glutamate/leucine/phenylalanine/valine dehydrogenases Cluster-8309.37365 BF_2 2796.87 23.79 5206 270011586 EFA08034.1 1458 2.9e-158 hypothetical protein TcasGA2_TC005623 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 Q1JPA0 1157 9.6e-125 Aldehyde dehydrogenase family 3 member B1 OS=Bos taurus GN=ALDH3B1 PE=2 SV=1 PF00171//PF07966 Aldehyde dehydrogenase family//A1 Propeptide GO:0006508//GO:0008152//GO:0055114 proteolysis//metabolic process//oxidation-reduction process GO:0004190//GO:0016491 aspartic-type endopeptidase activity//oxidoreductase activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.37366 BF_2 102.00 104.86 317 642922794 XP_008193328.1 402 5.0e-37 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 253 3.9e-21 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 PF06448 Domain of Unknown Function (DUF1081) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- -- -- Cluster-8309.37367 BF_2 3554.98 77.79 2199 91077280 XP_974370.1 319 1.5e-26 PREDICTED: uncharacterized protein LOC663220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37369 BF_2 21.18 0.38 2633 568251357 ETN60911.1 458 1.3e-42 troponin C [Anopheles darlingi] 768431929 XM_011558966.1 82 3.10671e-32 PREDICTED: Plutella xylostella troponin C (LOC105388115), mRNA -- -- -- -- P47947 250 7.2e-20 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF13499//PF00036//PF13833//PF13405//PF13202 EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.3737 BF_2 20.62 2.45 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37372 BF_2 25.48 1.16 1203 91076836 XP_974707.1 1278 5.0e-138 PREDICTED: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [Tribolium castaneum]>gi|270001821|gb|EEZ98268.1| hypothetical protein TcasGA2_TC000711 [Tribolium castaneum] 462377192 APGK01023399.1 60 2.37049e-20 Dendroctonus ponderosae Seq01023409, whole genome shotgun sequence K00167 BCKDHB, bkdA2 2-oxoisovalerate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00167 P35738 1068 4.6e-115 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Rattus norvegicus GN=Bckdhb PE=1 SV=3 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.37375 BF_2 141.51 1.29 4891 546685292 ERL94819.1 688 5.3e-69 hypothetical protein D910_12092 [Dendroctonus ponderosae] -- -- -- -- -- K18078 PTPDC1 protein tyrosine phosphatase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18078 A7E379 480 2.9e-46 Protein tyrosine phosphatase domain-containing protein 1 OS=Bos taurus GN=PTPDC1 PE=2 SV=2 PF00782//PF00102//PF03740//PF05706 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Pyridoxal phosphate biosynthesis protein PdxJ//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006470//GO:0006570//GO:0008615 protein dephosphorylation//tyrosine metabolic process//pyridoxine biosynthetic process GO:0004725//GO:0008138//GO:0033856//GO:0004721 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//pyridoxine 5'-phosphate synthase activity//phosphoprotein phosphatase activity GO:0005737 cytoplasm -- -- Cluster-8309.37377 BF_2 59.00 0.55 4753 189233706 XP_968287.2 796 1.5e-81 PREDICTED: protein tyrosine phosphatase domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- K18078 PTPDC1 protein tyrosine phosphatase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18078 A7E379 550 2.1e-54 Protein tyrosine phosphatase domain-containing protein 1 OS=Bos taurus GN=PTPDC1 PE=2 SV=2 PF00782//PF03740//PF00102//PF05706 Dual specificity phosphatase, catalytic domain//Pyridoxal phosphate biosynthesis protein PdxJ//Protein-tyrosine phosphatase//Cyclin-dependent kinase inhibitor 3 (CDKN3) GO:0006470//GO:0006570//GO:0008615 protein dephosphorylation//tyrosine metabolic process//pyridoxine biosynthetic process GO:0008138//GO:0004725//GO:0004721//GO:0033856 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//pyridoxine 5'-phosphate synthase activity GO:0005737 cytoplasm -- -- Cluster-8309.37378 BF_2 34.26 0.31 4871 576249472 AHH29250.1 2669 1.0e-298 Bedraggled-like protein [Leptinotarsa decemlineata] 576249471 KC713792.1 587 0 Leptinotarsa decemlineata Bedraggled-like protein mRNA, complete cds K05336 SLC6AN solute carrier family 6 (neurotransmitter transporter), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05336 Q99884 256 2.7e-20 Sodium-dependent proline transporter OS=Homo sapiens GN=SLC6A7 PE=2 SV=2 PF11421//PF00209 ATP synthase F1 beta subunit//Sodium:neurotransmitter symporter family GO:0006754//GO:0006812//GO:0006836 ATP biosynthetic process//cation transport//neurotransmitter transport GO:0016887//GO:0005328//GO:0005524 ATPase activity//neurotransmitter:sodium symporter activity//ATP binding GO:0000275//GO:0016021 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//integral component of membrane -- -- Cluster-8309.37379 BF_2 401.96 3.67 4871 91087973 XP_973205.1 2198 4.2e-244 PREDICTED: probable ribonuclease ZC3H12D isoform X1 [Tribolium castaneum] 642931021 XM_968112.2 306 1.74184e-156 PREDICTED: Tribolium castaneum probable ribonuclease ZC3H12B (LOC661984), transcript variant X1, mRNA K18668 ZC3H12, MCPIP ribonuclease ZC3H12 http://www.genome.jp/dbget-bin/www_bget?ko:K18668 Q5DTV4 843 2.3e-88 Probable ribonuclease ZC3H12C OS=Mus musculus GN=Zc3h12c PE=2 SV=2 PF07499//PF05157//PF00642 RuvA, C-terminal domain//Type II secretion system (T2SS), protein E, N-terminal domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006310//GO:0006281//GO:0006810 DNA recombination//DNA repair//transport GO:0046872//GO:0009378//GO:0005524 metal ion binding//four-way junction helicase activity//ATP binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG3777 Uncharacterized conserved protein Cluster-8309.37381 BF_2 32.37 0.36 3999 270005574 EFA02022.1 1711 1.0e-187 hypothetical protein TcasGA2_TC007647 [Tribolium castaneum] 642919114 XM_008193522.1 141 7.5445e-65 PREDICTED: Tribolium castaneum DDB1- and CUL4-associated factor 8 (LOC656756), mRNA K11804 WDR42A WD repeat-containing protein 42A http://www.genome.jp/dbget-bin/www_bget?ko:K11804 Q5TAQ9 992 1.0e-105 DDB1- and CUL4-associated factor 8 OS=Homo sapiens GN=DCAF8 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1334 WD40 repeat protein Cluster-8309.37382 BF_2 217.49 0.58 16023 546683698 ERL93476.1 2777 1.3e-310 hypothetical protein D910_10767, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07535//PF00096 DBF zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.37383 BF_2 34646.90 100.46 14715 642918534 XP_008191512.1 19331 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 3183 0 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 15785 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02480//PF13895//PF14980 Alphaherpesvirus glycoprotein E//Immunoglobulin domain//TIP39 peptide GO:0007218 neuropeptide signaling pathway GO:0005515 protein binding GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.37385 BF_2 622.29 5.10 5392 642911787 XP_008200742.1 4674 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X3 [Tribolium castaneum] 642911788 XM_967563.3 511 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 O15021 2207 1.7e-246 Microtubule-associated serine/threonine-protein kinase 4 OS=Homo sapiens GN=MAST4 PE=1 SV=3 PF08926//PF00595//PF00069//PF06293//PF13180//PF07714 Domain of unknown function (DUF1908)//PDZ domain (Also known as DHR or GLGF)//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//PDZ domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0005524//GO:0004672//GO:0004674//GO:0000287//GO:0016773 protein binding//ATP binding//protein kinase activity//protein serine/threonine kinase activity//magnesium ion binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.37389 BF_2 1111.93 5.35 8977 307208309 EFN85734.1 1919 1.8e-211 Fatty acid synthase [Harpegnathos saltator] 815792597 XM_012361475.1 47 3.05576e-12 PREDICTED: Linepithema humile fatty acid synthase-like (LOC105668856), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1073 9.1e-115 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF02826//PF00107//PF05524//PF00975//PF00106 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase//PEP-utilising enzyme, N-terminal//Thioesterase domain//short chain dehydrogenase GO:0055114//GO:0009058//GO:0008152//GO:0009401 oxidation-reduction process//biosynthetic process//metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0051287//GO:0016491//GO:0016788 NAD binding//oxidoreductase activity//hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.37390 BF_2 60.21 0.42 6290 642915997 XP_008190849.1 3607 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] 642915996 XM_008192627.1 306 2.25198e-156 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 P11799 919 4.6e-97 Myosin light chain kinase, smooth muscle OS=Gallus gallus GN=Mylk PE=1 SV=2 PF00041//PF13895//PF16656//PF02480//PF07714//PF00069//PF06293 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006771//GO:0019497//GO:0006468 riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0003993//GO:0016773//GO:0004672//GO:0046872//GO:0005524//GO:0005515 acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//metal ion binding//ATP binding//protein binding GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37391 BF_2 519.00 10.77 2303 189234874 XP_973619.2 1312 1.1e-141 PREDICTED: cytochrome P450 9e2 [Tribolium castaneum]>gi|270002740|gb|EEZ99187.1| cytochrome P450 9AD1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1040 1.6e-111 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0016705//GO:0005488 heme binding//iron ion binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.37392 BF_2 41.34 0.59 3218 91090103 XP_970810.1 2084 4.6e-231 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 195386227 XM_002051770.1 107 4.81729e-46 Drosophila virilis GJ17194 (Dvir\GJ17194), mRNA -- -- -- -- Q96PX1 1035 8.3e-111 RING finger protein 157 OS=Homo sapiens GN=RNF157 PE=1 SV=3 PF13639//PF03544//PF03854//PF00252//PF14634 Ring finger domain//Gram-negative bacterial TonB protein C-terminal//P-11 zinc finger//Ribosomal protein L16p/L10e//zinc-RING finger domain GO:0042254//GO:0006412//GO:0006810 ribosome biogenesis//translation//transport GO:0003735//GO:0008270//GO:0043169//GO:0003723//GO:0005515 structural constituent of ribosome//zinc ion binding//cation binding//RNA binding//protein binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.37393 BF_2 47.76 0.39 5433 478262467 ENN81138.1 1903 7.6e-210 hypothetical protein YQE_02505, partial [Dendroctonus ponderosae] -- -- -- -- -- K14258 TRET1 facilitated trehalose transporter http://www.genome.jp/dbget-bin/www_bget?ko:K14258 Q17NV8 1407 1.0e-153 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.37394 BF_2 5587.00 832.04 568 264667407 ACY71289.1 505 1.0e-48 ribosomal protein L31 [Chrysomela tremula] 749782899 XM_011147233.1 95 3.79035e-40 PREDICTED: Harpegnathos saltator 60S ribosomal protein L31 (LOC105186788), transcript variant X2, mRNA K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 Q9GP16 463 3.1e-45 60S ribosomal protein L31 OS=Heliothis virescens GN=RpL31 PE=2 SV=1 PF01198 Ribosomal protein L31e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0893 60S ribosomal protein L31 Cluster-8309.37396 BF_2 287.92 5.11 2643 91092648 XP_969941.1 1980 4.4e-219 PREDICTED: tyrosine-protein kinase Drl [Tribolium castaneum]>gi|270014831|gb|EFA11279.1| hypothetical protein TcasGA2_TC010814 [Tribolium castaneum] -- -- -- -- -- K05128 RYK RYK receptor-like tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05128 Q9V422 1277 5.9e-139 Tyrosine-protein kinase Dnt OS=Drosophila melanogaster GN=dnt PE=2 SV=2 PF07714//PF02198//PF00069 Protein tyrosine kinase//Sterile alpha motif (SAM)/Pointed domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0004713//GO:0043565//GO:0005524//GO:0004672 protein tyrosine kinase activity//sequence-specific DNA binding//ATP binding//protein kinase activity GO:0005634 nucleus KOG1024 Receptor-like protein tyrosine kinase RYK/derailed Cluster-8309.37398 BF_2 4324.21 83.33 2458 91083675 XP_968367.1 2070 1.5e-229 PREDICTED: serine/threonine-protein kinase PINK1, mitochondrial [Tribolium castaneum]>gi|270006820|gb|EFA03268.1| hypothetical protein TcasGA2_TC013202 [Tribolium castaneum] -- -- -- -- -- K05688 PINK1 PTEN induced putative kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05688 Q9BXM7 729 1.9e-75 Serine/threonine-protein kinase PINK1, mitochondrial OS=Homo sapiens GN=PINK1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG4158 BRPK/PTEN-induced protein kinase Cluster-8309.37399 BF_2 2059.00 80.14 1362 642922690 XP_008193282.1 1127 1.8e-120 PREDICTED: basement membrane-specific heparan sulfate proteoglycan core protein isoform X14 [Tribolium castaneum] -- -- -- -- -- K06255 HSPG2 heparan sulfate proteoglycan 2 (perlecan) http://www.genome.jp/dbget-bin/www_bget?ko:K06255 P98160 286 2.5e-24 Basement membrane-specific heparan sulfate proteoglycan core protein OS=Homo sapiens GN=HSPG2 PE=1 SV=4 PF00008//PF13895 EGF-like domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3509 Basement membrane-specific heparan sulfate proteoglycan (HSPG) core protein Cluster-8309.3740 BF_2 5.00 1.36 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37402 BF_2 55.06 1.02 2548 270016484 EFA12930.1 300 2.7e-24 hypothetical protein TcasGA2_TC010476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35554 173 5.9e-11 Flightin OS=Drosophila melanogaster GN=fln PE=2 SV=1 PF05529 B-cell receptor-associated protein 31-like GO:0006886 intracellular protein transport -- -- GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.37403 BF_2 2138.00 46.71 2202 189234116 XP_968417.2 320 1.1e-26 PREDICTED: uridine phosphorylase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00757 udp, UPP uridine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37406 BF_2 2045.29 8.13 10816 91090089 XP_975854.1 857 3.0e-88 PREDICTED: protein Tob1 [Tribolium castaneum]>gi|270013495|gb|EFA09943.1| hypothetical protein TcasGA2_TC012096 [Tribolium castaneum] 642934619 XM_970761.2 381 0 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 Q8R5K6 502 1.8e-48 Protein Tob1 OS=Rattus norvegicus GN=Tob1 PE=2 SV=1 PF10766 Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0015893 drug transmembrane transport//drug transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.37408 BF_2 1430.07 10.11 6203 189236151 XP_974913.2 6311 0.0e+00 PREDICTED: tyrosine-protein phosphatase 10D isoform X3 [Tribolium castaneum] 687022658 LM525572.1 65 2.07897e-22 Strongyloides papillosus genome assembly S_papillosus_LIN ,scaffold SPAL_scaffold0000013 K05694 PTPRB, PTPB receptor-type tyrosine-protein phosphatase beta http://www.genome.jp/dbget-bin/www_bget?ko:K05694 P35992 5177 0.0e+00 Tyrosine-protein phosphatase 10D OS=Drosophila melanogaster GN=Ptp10D PE=1 SV=4 PF00102//PF16656//PF00041//PF16794//PF00782 Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Fibronectin-III type domain//Dual specificity phosphatase, catalytic domain GO:0019497//GO:0006570//GO:0006470//GO:0006771 hexachlorocyclohexane metabolic process//tyrosine metabolic process//protein dephosphorylation//riboflavin metabolic process GO:0004725//GO:0008138//GO:0005515//GO:0046872//GO:0003993 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//metal ion binding//acid phosphatase activity -- -- KOG0791 Protein tyrosine phosphatase, contains fn3 domain Cluster-8309.37409 BF_2 100.83 0.66 6642 749791192 XP_011148786.1 1021 1.8e-107 PREDICTED: glycogen synthase kinase-3 beta-like isoform X6 [Harpegnathos saltator] 642920086 XM_008193977.1 215 9.18268e-106 PREDICTED: Tribolium castaneum shaggy (LOC664299), transcript variant X4, mRNA K03083 GSK3B glycogen synthase kinase 3 beta http://www.genome.jp/dbget-bin/www_bget?ko:K03083 P18431 895 2.9e-94 Protein kinase shaggy OS=Drosophila melanogaster GN=sgg PE=1 SV=3 PF07714//PF14552//PF06293//PF00069 Protein tyrosine kinase//Tautomerase enzyme//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006725//GO:0006468 cellular aromatic compound metabolic process//protein phosphorylation GO:0004672//GO:0016853//GO:0016773//GO:0005524 protein kinase activity//isomerase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0658 Glycogen synthase kinase-3 Cluster-8309.37410 BF_2 2276.08 7.42 13112 642920090 XP_008192200.1 1354 8.4e-146 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920091 XM_970322.3 333 4.60999e-171 PREDICTED: Tribolium castaneum 40S ribosomal protein S2 (LOC664315), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q960X4 1234 2.8e-133 Histone acetyltransferase Tip60 OS=Drosophila melanogaster GN=Tip60 PE=1 SV=1 PF03719//PF13855//PF00560//PF01853//PF00333//PF05261//PF00583//PF13508 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//Leucine Rich Repeat//MOZ/SAS family//Ribosomal protein S5, N-terminal domain//TraM protein, DNA-binding//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0000746//GO:0042254//GO:0006355//GO:0042967//GO:0006412 conjugation//ribosome biogenesis//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//translation GO:0016747//GO:0003735//GO:0005515//GO:0008080//GO:0003677//GO:0003723 transferase activity, transferring acyl groups other than amino-acyl groups//structural constituent of ribosome//protein binding//N-acetyltransferase activity//DNA binding//RNA binding GO:0005840//GO:0005634 ribosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.37412 BF_2 5040.88 121.27 2026 642925814 XP_970128.3 661 3.0e-66 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 504 2.0e-49 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.37413 BF_2 278.63 5.51 2401 91076170 XP_971503.1 2162 3.1e-240 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 401 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.0e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.37414 BF_2 1027.80 37.20 1443 642925809 XP_969782.3 644 2.0e-64 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 479 1.1e-46 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- -- -- Cluster-8309.37415 BF_2 1003.81 11.78 3851 642923667 XP_008193834.1 3361 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1117 3.1e-120 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03193//PF00005//PF13304//PF00664 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.37416 BF_2 93.17 1.51 2876 546684533 ERL94164.1 1157 1.3e-123 hypothetical protein D910_11446, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37417 BF_2 27.00 0.87 1586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37418 BF_2 220.89 0.93 10255 642934181 XP_008199641.1 2452 3.1e-273 PREDICTED: uncharacterized protein LOC657682 isoform X2 [Tribolium castaneum] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 1.8e-215 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF17095//PF10510//PF00628//PF07649//PF00183//PF00130//PF04857 Spectrin-binding region of Ca2+-Calmodulin//Phosphatidylinositol-glycan biosynthesis class S protein//PHD-finger//C1-like domain//Hsp90 protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//CAF1 family ribonuclease GO:0006457//GO:0006950//GO:0016255//GO:0031175//GO:0055114//GO:0035556 protein folding//response to stress//attachment of GPI anchor to protein//neuron projection development//oxidation-reduction process//intracellular signal transduction GO:0030507//GO:0005516//GO:0005524//GO:0005515//GO:0051082//GO:0047134 spectrin binding//calmodulin binding//ATP binding//protein binding//unfolded protein binding//protein-disulfide reductase activity GO:0005634//GO:0008091//GO:0042765 nucleus//spectrin//GPI-anchor transamidase complex KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.37419 BF_2 23033.25 245.62 4210 678336953 CDW75723.1 506 5.8e-48 UNKNOWN [Stylonychia lemnae] 375005309 JN619131.1 1869 0 Pogonocherus hispidulus voucher BMNH:835571 18S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37421 BF_2 18.75 0.41 2193 478263359 ENN81735.1 159 5.2e-08 hypothetical protein YQE_01874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37422 BF_2 352.53 4.33 3693 270008954 EFA05402.1 882 1.3e-91 hypothetical protein TcasGA2_TC015574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37423 BF_2 593.25 2.31 11021 642922880 XP_008200435.1 6064 0.0e+00 PREDICTED: maestro heat-like repeat-containing protein family member 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDA8 1421 5.0e-155 Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 PF00096//PF07178//PF11698//PF00628//PF01429//PF05485//PF02985 Zinc finger, C2H2 type//TraL protein//V-ATPase subunit H//PHD-finger//Methyl-CpG binding domain//THAP domain//HEAT repeat GO:0015991//GO:0000746 ATP hydrolysis coupled proton transport//conjugation GO:0016820//GO:0005515//GO:0003677//GO:0046872//GO:0003676 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//DNA binding//metal ion binding//nucleic acid binding GO:0000221//GO:0005634//GO:0019867 vacuolar proton-transporting V-type ATPase, V1 domain//nucleus//outer membrane KOG2032 Uncharacterized conserved protein Cluster-8309.37425 BF_2 104.17 4.62 1230 307174197 EFN64842.1 147 7.2e-07 hypothetical protein EAG_03612 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37426 BF_2 364.57 1.36 11503 642935534 XP_008198048.1 1716 7.8e-188 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X2 [Tribolium castaneum] 755889203 XM_005188558.2 102 1.04439e-42 PREDICTED: Musca domestica vesicular integral-membrane protein VIP36 (LOC101894935), mRNA K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q7L273 986 1.4e-104 BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens GN=KCTD9 PE=1 SV=1 PF02214//PF02017//PF00139//PF03120//PF03388 BTB/POZ domain//CIDE-N domain//Legume lectin domain//NAD-dependent DNA ligase OB-fold domain//Legume-like lectin family GO:0006260//GO:0006915//GO:0051260//GO:0006281 DNA replication//apoptotic process//protein homooligomerization//DNA repair GO:0030246//GO:0003911 carbohydrate binding//DNA ligase (NAD+) activity GO:0016020//GO:0005622 membrane//intracellular KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.37427 BF_2 1049.58 14.24 3371 288869514 NP_001165864.1 2852 0.0e+00 extended synaptotagmin-like protein 2a [Tribolium castaneum]>gi|642923659|ref|XP_008193831.1| PREDICTED: extended synaptotagmin-like protein 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 964 1.5e-102 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.37429 BF_2 48.35 1.06 2201 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16045 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.3743 BF_2 20.66 0.33 2897 189236336 XP_001816307.1 1044 1.6e-110 PREDICTED: general transcription factor IIH subunit 1 [Tribolium castaneum]>gi|270005862|gb|EFA02310.1| hypothetical protein TcasGA2_TC007976 [Tribolium castaneum] -- -- -- -- -- K03141 TFIIH1, GTF2H1, TFB1 transcription initiation factor TFIIH subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03141 Q960E8 891 3.7e-94 General transcription factor IIH subunit 1 OS=Drosophila melanogaster GN=Tfb1 PE=2 SV=1 PF07289 Protein of unknown function (DUF1448) -- -- -- -- GO:0034464 BBSome KOG2074 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 Cluster-8309.37431 BF_2 1184.82 25.11 2261 642910653 XP_968714.2 302 1.4e-24 PREDICTED: polyadenylate-binding protein-interacting protein 2B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37433 BF_2 956.00 69.09 866 91086657 XP_967917.1 873 3.3e-91 PREDICTED: proteasome subunit beta type-2 [Tribolium castaneum]>gi|270009752|gb|EFA06200.1| hypothetical protein TcasGA2_TC009049 [Tribolium castaneum] -- -- -- -- -- K02734 PSMB2 20S proteasome subunit beta 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02734 P40307 656 2.0e-67 Proteasome subunit beta type-2 OS=Rattus norvegicus GN=Psmb2 PE=1 SV=1 PF00227 Proteasome subunit GO:0051603 proteolysis involved in cellular protein catabolic process GO:0004298 threonine-type endopeptidase activity GO:0005737//GO:0005634//GO:0005839 cytoplasm//nucleus//proteasome core complex KOG0177 20S proteasome, regulatory subunit beta type PSMB2/PRE1 Cluster-8309.37434 BF_2 47.65 0.35 5997 642910328 XP_008200285.1 3165 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270014917|gb|EFA11365.1| hypothetical protein TcasGA2_TC011522 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1913 2.4e-212 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00975//PF00106//PF00107//PF01764 Thioesterase domain//short chain dehydrogenase//Zinc-binding dehydrogenase//Lipase (class 3) GO:0006629//GO:0042967//GO:0008152//GO:0006633//GO:0055114//GO:0009058 lipid metabolic process//acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process//oxidation-reduction process//biosynthetic process GO:0016491//GO:0016788//GO:0016297 oxidoreductase activity//hydrolase activity, acting on ester bonds//acyl-[acyl-carrier-protein] hydrolase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.37435 BF_2 4490.46 7.88 24116 270014225 EFA10673.1 8598 0.0e+00 muscle-specific protein 300 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 676 2.6e-68 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF14867//PF10541//PF00435//PF00837 Lantibiotic alpha//Nuclear envelope localisation domain//Spectrin repeat//Iodothyronine deiodinase GO:0055114//GO:0050830 oxidation-reduction process//defense response to Gram-positive bacterium GO:0005515//GO:0004800 protein binding//thyroxine 5'-deiodinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.37436 BF_2 184.20 2.61 3236 642939797 XP_970220.2 1685 8.6e-185 PREDICTED: uncharacterized protein LOC658765 [Tribolium castaneum] 642939796 XM_965127.2 524 0 PREDICTED: Tribolium castaneum uncharacterized LOC658765 (LOC658765), mRNA K03649 MUG, TDG TDG/mug DNA glycosylase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03649 Q13569 615 4.2e-62 G/T mismatch-specific thymine DNA glycosylase OS=Homo sapiens GN=TDG PE=1 SV=2 PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- KOG4120 G/T mismatch-specific thymine DNA glycosylase Cluster-8309.37437 BF_2 325.00 3.06 4724 91080527 XP_972163.1 746 9.6e-76 PREDICTED: alpha- and gamma-adaptin-binding protein p34 [Tribolium castaneum]>gi|270005544|gb|EFA01992.1| hypothetical protein TcasGA2_TC007613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PD74 295 7.8e-25 Alpha- and gamma-adaptin-binding protein p34 OS=Homo sapiens GN=AAGAB PE=1 SV=1 PF05367//PF08408 Phage endonuclease I//DNA polymerase family B viral insert GO:0016032//GO:0006260//GO:0006308//GO:0015074 viral process//DNA replication//DNA catabolic process//DNA integration GO:0003887//GO:0008833 DNA-directed DNA polymerase activity//deoxyribonuclease IV (phage-T4-induced) activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.37438 BF_2 9939.80 162.62 2844 91092022 XP_970951.1 743 1.3e-75 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q95029 629 8.8e-64 Cathepsin L OS=Drosophila melanogaster GN=Cp1 PE=2 SV=2 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37439 BF_2 690.55 8.23 3799 270014908 EFA11356.1 4662 0.0e+00 hypothetical protein TcasGA2_TC011512 [Tribolium castaneum] 766942063 XM_011505379.1 303 6.30721e-155 PREDICTED: Ceratosolen solmsi marchali ubiquitin-like modifier-activating enzyme 1 (LOC105366815), mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 Q29504 3515 0.0e+00 Ubiquitin-like modifier-activating enzyme 1 OS=Oryctolagus cuniculus GN=UBA1 PE=2 SV=1 PF13241//PF00899//PF00070//PF01006 Putative NAD(P)-binding//ThiF family//Pyridine nucleotide-disulphide oxidoreductase//Hepatitis C virus non-structural protein NS4a GO:0006779//GO:0055114//GO:0016032//GO:0019354 porphyrin-containing compound biosynthetic process//oxidation-reduction process//viral process//siroheme biosynthetic process GO:0008641//GO:0016491//GO:0043115 small protein activating enzyme activity//oxidoreductase activity//precorrin-2 dehydrogenase activity GO:0019012 virion KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.37440 BF_2 467.00 59.95 613 642926167 XP_008194812.1 596 3.1e-59 PREDICTED: vinculin isoform X2 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 504 5.9e-50 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044 Vinculin family GO:0007155 cell adhesion GO:0051015 actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.37441 BF_2 7992.74 126.90 2922 385199948 AFI45022.1 1108 6.3e-118 cytochrome P450 CYP4g56 [Dendroctonus ponderosae] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VYY4 872 6.0e-92 Cytochrome P450 4g15 OS=Drosophila melanogaster GN=Cyp4g15 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0157 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies Cluster-8309.37442 BF_2 243.00 6.86 1770 478259091 ENN79026.1 772 3.5e-79 hypothetical protein YQE_04528, partial [Dendroctonus ponderosae] -- -- -- -- -- K14295 NUP50, NPAP60 nuclear pore complex protein Nup50 http://www.genome.jp/dbget-bin/www_bget?ko:K14295 Q9UKX7 258 5.7e-21 Nuclear pore complex protein Nup50 OS=Homo sapiens GN=NUP50 PE=1 SV=2 PF00638//PF08911 RanBP1 domain//NUP50 (Nucleoporin 50 kDa) GO:0046907 intracellular transport -- -- GO:0005643 nuclear pore -- -- Cluster-8309.37443 BF_2 344.00 13.13 1383 91086645 XP_967184.1 1227 4.7e-132 PREDICTED: lipoma HMGIC fusion partner-like 3 protein [Tribolium castaneum]>gi|270010387|gb|EFA06835.1| hypothetical protein TcasGA2_TC009778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86UP9 563 1.9e-56 Lipoma HMGIC fusion partner-like 3 protein OS=Homo sapiens GN=LHFPL3 PE=2 SV=3 PF00822//PF13903//PF02962 PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction//5-carboxymethyl-2-hydroxymuconate isomerase GO:0018874//GO:0019439//GO:0006570 benzoate metabolic process//aromatic compound catabolic process//tyrosine metabolic process GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity GO:0016021 integral component of membrane KOG4026 Uncharacterized conserved protein Cluster-8309.37444 BF_2 217.68 1.37 6929 642922445 XP_008193172.1 5130 0.0e+00 PREDICTED: uncharacterized protein LOC655273 [Tribolium castaneum] 665794170 XM_008546548.1 48 6.54984e-13 PREDICTED: Microplitis demolitor adenylate cyclase type 8 (LOC103569316), transcript variant X1, mRNA K08048 ADCY8 adenylate cyclase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08048 P40145 1172 2.3e-126 Adenylate cyclase type 8 OS=Homo sapiens GN=ADCY8 PE=1 SV=1 PF00211//PF15168//PF06327//PF07701 Adenylate and Guanylate cyclase catalytic domain//Triple QxxK/R motif-containing protein family//Domain of Unknown Function (DUF1053)//Heme NO binding associated GO:0035556//GO:0009190//GO:0006171//GO:0006144//GO:0006182//GO:0046039 intracellular signal transduction//cyclic nucleotide biosynthetic process//cAMP biosynthetic process//purine nucleobase metabolic process//cGMP biosynthetic process//GTP metabolic process GO:0016849//GO:0004016//GO:0004383 phosphorus-oxygen lyase activity//adenylate cyclase activity//guanylate cyclase activity GO:0005789//GO:0005886 endoplasmic reticulum membrane//plasma membrane -- -- Cluster-8309.37445 BF_2 1327.56 41.45 1627 478251085 ENN71561.1 1611 1.7e-176 hypothetical protein YQE_11663, partial [Dendroctonus ponderosae] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q5RAS0 1345 4.7e-147 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Pongo abelii GN=ACADS PE=2 SV=1 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.37446 BF_2 489.34 1.84 11402 642934317 XP_008198598.1 2239 1.8e-248 PREDICTED: integrin alpha-PS2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 1688 5.6e-186 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF15686//PF05375 Lysine-rich CEACAM1 co-isolated protein family//Pacifastin inhibitor (LCMII) GO:0045766//GO:0043123//GO:0043066 positive regulation of angiogenesis//positive regulation of I-kappaB kinase/NF-kappaB signaling//negative regulation of apoptotic process GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.37450 BF_2 617.16 18.55 1679 189238828 XP_969342.2 1477 5.9e-161 PREDICTED: peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 isoform X1 [Tribolium castaneum]>gi|270009957|gb|EFA06405.1| hypothetical protein TcasGA2_TC009284 [Tribolium castaneum] -- -- -- -- -- K18200 PAL peptidylamidoglycolate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K18200 Q9W1L5 1013 1.5e-108 Peptidyl-alpha-hydroxyglycine alpha-amidating lyase 2 OS=Drosophila melanogaster GN=Pal2 PE=1 SV=2 PF01436//PF01983 NHL repeat//Guanylyl transferase CofC like GO:0055114//GO:0006518 oxidation-reduction process//peptide metabolic process GO:0004504//GO:0005507//GO:0016779//GO:0005515 peptidylglycine monooxygenase activity//copper ion binding//nucleotidyltransferase activity//protein binding GO:0016020 membrane KOG3567 Peptidylglycine alpha-amidating monooxygenase Cluster-8309.37451 BF_2 2747.20 19.08 6311 546681613 ERL91677.1 2243 3.3e-249 hypothetical protein D910_09004 [Dendroctonus ponderosae] 241591921 XM_002403988.1 180 2.49479e-86 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19029 PFKFB2 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19029 Q91309 1435 6.8e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF01591//PF00973//PF05470//PF06414 6-phosphofructo-2-kinase//Paramyxovirus nucleocapsid protein//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Zeta toxin GO:0006013//GO:0006000//GO:0006413//GO:0006446 mannose metabolic process//fructose metabolic process//translational initiation//regulation of translational initiation GO:0031369//GO:0016301//GO:0005198//GO:0003873//GO:0005524//GO:0003743 translation initiation factor binding//kinase activity//structural molecule activity//6-phosphofructo-2-kinase activity//ATP binding//translation initiation factor activity GO:0019013//GO:0005852//GO:0005840 viral nucleocapsid//eukaryotic translation initiation factor 3 complex//ribosome KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.37453 BF_2 2063.22 24.74 3776 91091818 XP_966528.1 1785 2.6e-196 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1302 1.1e-141 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF10613//PF00060//PF06495//PF03509//PF06859 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Fruit fly transformer protein//Gap junction alpha-8 protein (Cx50)//Bicoid-interacting protein 3 (Bin3) GO:0007165//GO:0006397//GO:0007268//GO:0006810//GO:0046660//GO:0007154//GO:0006811 signal transduction//mRNA processing//synaptic transmission//transport//female sex differentiation//cell communication//ion transport GO:0005215//GO:0005234//GO:0004970//GO:0008168 transporter activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//methyltransferase activity GO:0005634//GO:0016020//GO:0005922 nucleus//membrane//connexon complex -- -- Cluster-8309.37454 BF_2 228.00 1.46 6812 795370015 XP_011748985.1 261 2.4e-19 PREDICTED: neurofilament heavy polypeptide isoform X4 [Macaca nemestrina]>gi|795370020|ref|XP_011748986.1| PREDICTED: neurofilament heavy polypeptide isoform X5 [Macaca nemestrina]>gi|795370026|ref|XP_011748987.1| PREDICTED: neurofilament heavy polypeptide isoform X6 [Macaca nemestrina] -- -- -- -- -- -- -- -- -- P12036 226 1.1e-16 Neurofilament heavy polypeptide OS=Homo sapiens GN=NEFH PE=1 SV=4 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.37455 BF_2 118.06 4.03 1514 642914509 XP_008201706.1 624 4.3e-62 PREDICTED: transcriptional enhancer factor TEF-1 isoform X1 [Tribolium castaneum] 642914508 XM_008203484.1 168 2.75736e-80 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X1, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P30052 502 2.5e-49 Protein scalloped OS=Drosophila melanogaster GN=sd PE=1 SV=1 PF00424//PF01285 REV protein (anti-repression trans-activator protein)//TEA/ATTS domain family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634//GO:0042025 transcription factor complex//nucleus//host cell nucleus KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.37456 BF_2 209.86 2.75 3484 642914509 XP_008201706.1 1580 1.4e-172 PREDICTED: transcriptional enhancer factor TEF-1 isoform X1 [Tribolium castaneum] 642914508 XM_008203484.1 507 0 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X1, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P28347 1170 2.0e-126 Transcriptional enhancer factor TEF-1 OS=Homo sapiens GN=TEAD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.37457 BF_2 363.99 181.93 368 350646286 CCD59012.1 148 1.6e-07 saposin containing protein [Schistosoma mansoni] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37458 BF_2 3107.16 29.01 4767 642933145 XP_008197275.1 2063 1.9e-228 PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum]>gi|642933147|ref|XP_008197277.1| PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum] 642933146 XM_008199055.1 280 4.84044e-142 PREDICTED: Tribolium castaneum extracellular serine/threonine protein kinase FAM20C (LOC662687), transcript variant X2, mRNA -- -- -- -- A4VCL2 1488 3.6e-163 Extracellular serine/threonine protein CG31145 OS=Drosophila melanogaster GN=CG31145 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.37459 BF_2 4432.10 50.21 3980 546676946 ERL87870.1 631 1.8e-62 hypothetical protein D910_05258 [Dendroctonus ponderosae] 817210375 XM_012425850.1 99 1.67192e-41 PREDICTED: Orussus abietinus gamma-aminobutyric acid receptor-associated protein (LOC105700198), mRNA K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 Q9GJW7 574 2.9e-57 Gamma-aminobutyric acid receptor-associated protein OS=Bos taurus GN=GABARAP PE=3 SV=2 PF04110//PF00961 Ubiquitin-like autophagy protein Apg12//LAGLIDADG endonuclease GO:0000045 autophagosome assembly GO:0004519 endonuclease activity GO:0005737 cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-8309.37460 BF_2 3018.13 193.69 939 642915391 XP_008190597.1 403 1.1e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 8.36861e-34 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 6.1e-22 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF02297 Cytochrome oxidase c subunit VIb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005739 respiratory chain complex IV//mitochondrion KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.37461 BF_2 535.22 3.78 6211 478253975 ENN74267.1 3030 0.0e+00 hypothetical protein YQE_09239, partial [Dendroctonus ponderosae] 642910904 XM_008195237.1 248 3.88393e-124 PREDICTED: Tribolium castaneum trithorax group protein osa (LOC100141527), mRNA K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 1475 1.5e-161 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 PF15750//PF01388//PF12031//PF00375//PF01435 Ubiquitin-binding zinc-finger//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518)//Sodium:dicarboxylate symporter family//Peptidase family M48 GO:0006338//GO:0006820//GO:0006835//GO:0006812//GO:0006508 chromatin remodeling//anion transport//dicarboxylic acid transport//cation transport//proteolysis GO:0043130//GO:0004222//GO:0003677//GO:0017153 ubiquitin binding//metalloendopeptidase activity//DNA binding//sodium:dicarboxylate symporter activity GO:0090544//GO:0016020 BAF-type complex//membrane KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-8309.37462 BF_2 482.40 3.51 6041 478253975 ENN74267.1 3030 0.0e+00 hypothetical protein YQE_09239, partial [Dendroctonus ponderosae] 642910904 XM_008195237.1 326 1.64887e-167 PREDICTED: Tribolium castaneum trithorax group protein osa (LOC100141527), mRNA K11653 ARID1 AT-rich interactive domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11653 Q8IN94 1475 1.5e-161 Trithorax group protein osa OS=Drosophila melanogaster GN=osa PE=1 SV=1 PF01388//PF00375//PF12031//PF15750//PF01435 ARID/BRIGHT DNA binding domain//Sodium:dicarboxylate symporter family//Domain of unknown function (DUF3518)//Ubiquitin-binding zinc-finger//Peptidase family M48 GO:0006338//GO:0006820//GO:0006812//GO:0006835//GO:0006508 chromatin remodeling//anion transport//cation transport//dicarboxylic acid transport//proteolysis GO:0004222//GO:0043130//GO:0003677//GO:0017153 metalloendopeptidase activity//ubiquitin binding//DNA binding//sodium:dicarboxylate symporter activity GO:0090544//GO:0016020 BAF-type complex//membrane KOG2510 SWI-SNF chromatin-remodeling complex protein Cluster-8309.37463 BF_2 648.84 9.06 3282 189241616 XP_966968.2 900 9.3e-94 PREDICTED: cyclic AMP response element-binding protein A-like isoform X3 [Tribolium castaneum] 195590478 XM_002084937.1 97 1.78e-40 Drosophila simulans GD14552 (Dsim\GD14552), mRNA K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 P29747 388 8.9e-36 Cyclic AMP response element-binding protein A OS=Drosophila melanogaster GN=CrebA PE=1 SV=2 PF04111//PF01544//PF00170//PF06005//PF03131//PF07926//PF07716//PF02183 Autophagy protein Apg6//CorA-like Mg2+ transporter protein//bZIP transcription factor//Protein of unknown function (DUF904)//bZIP Maf transcription factor//TPR/MLP1/MLP2-like protein//Basic region leucine zipper//Homeobox associated leucine zipper GO:0000917//GO:0043093//GO:0006606//GO:0006355//GO:0006914//GO:0030001//GO:0055085 barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//metal ion transport//transmembrane transport GO:0003700//GO:0043565//GO:0046873//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//metal ion transmembrane transporter activity//DNA binding GO:0005737//GO:0016020//GO:0005667//GO:0005634 cytoplasm//membrane//transcription factor complex//nucleus KOG0709 CREB/ATF family transcription factor Cluster-8309.37464 BF_2 24.23 1.36 1034 478259808 ENN79636.1 194 2.1e-12 hypothetical protein YQE_03925, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- -- -- Cluster-8309.37466 BF_2 16813.53 236.19 3265 642928069 XP_968571.3 1731 4.0e-190 PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|642928071|ref|XP_008200143.1| PREDICTED: ornithine decarboxylase 1-like [Tribolium castaneum]>gi|270010871|gb|EFA07319.1| hypothetical protein TcasGA2_TC015912 [Tribolium castaneum] -- -- -- -- -- K01581 E4.1.1.17, ODC1, speC, speF ornithine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01581 P27117 1041 1.7e-111 Ornithine decarboxylase OS=Bos taurus GN=ODC1 PE=2 SV=1 PF00278//PF02784 Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain GO:0006596 polyamine biosynthetic process GO:0003824 catalytic activity -- -- KOG0622 Ornithine decarboxylase Cluster-8309.37467 BF_2 3947.39 31.77 5484 91078042 XP_966587.1 1233 3.8e-132 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCI3 792 2.1e-82 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37468 BF_2 24.52 0.73 1683 546683249 ERL93081.1 549 2.4e-53 hypothetical protein D910_10383 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q71RG4 208 3.4e-15 Transmembrane and ubiquitin-like domain-containing protein 2 OS=Homo sapiens GN=TMUB2 PE=1 SV=2 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37469 BF_2 3582.78 27.99 5641 270009349 EFA05797.1 798 1.1e-81 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 463 3.1e-44 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.3747 BF_2 7.00 0.51 858 675384152 KFM77049.1 193 2.3e-12 Ankyrin repeat and KH domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q8Q0U0 176 8.9e-12 Putative ankyrin repeat protein MM_0045 OS=Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) GN=MM_0045 PE=3 SV=1 PF13606 Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37470 BF_2 151.77 1.34 5020 270009349 EFA05797.1 447 4.8e-41 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 275 1.7e-22 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.37472 BF_2 61.66 0.88 3211 642932670 XP_008196939.1 401 6.6e-36 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 2.8e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF02179 BAG domain -- -- GO:0051087 chaperone binding -- -- -- -- Cluster-8309.37474 BF_2 86.66 0.68 5646 642936679 XP_008198534.1 580 2.0e-56 PREDICTED: protein rhomboid isoform X1 [Tribolium castaneum] 751781411 XM_011201569.1 47 1.91815e-12 PREDICTED: Bactrocera dorsalis cAMP-responsive element-binding protein-like 2 (LOC105223754), mRNA -- -- -- -- A4IGK3 291 2.7e-24 cAMP-responsive element-binding protein-like 2 OS=Xenopus tropicalis GN=crebl2 PE=3 SV=1 PF05832//PF01694//PF00170//PF07716 Eukaryotic protein of unknown function (DUF846)//Rhomboid family//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0004252//GO:0003700 sequence-specific DNA binding//serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG2289 Rhomboid family proteins Cluster-8309.37475 BF_2 144.00 148.03 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37476 BF_2 2432.85 12.61 8360 189236706 XP_974173.2 1532 1.2e-166 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 349 3.74272e-180 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 652 5.6e-66 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.37477 BF_2 1052.00 9.79 4784 642929898 XP_975679.2 1290 8.1e-139 PREDICTED: protein CASC3 [Tribolium castaneum] -- -- -- -- -- K07951 ARL6, BBS3 ADP-ribosylation factor-like protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K07951 Q5M9P8 512 5.5e-50 ADP-ribosylation factor-like protein 6 OS=Danio rerio GN=arl6 PE=2 SV=1 PF08477//PF04995//PF01926//PF00025//PF02421//PF00503//PF00071//PF04670//PF01580 Ras of Complex, Roc, domain of DAPkinase//Heme exporter protein D (CcmD)//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ferrous iron transport protein B//G-protein alpha subunit//Ras family//Gtr1/RagA G protein conserved region//FtsK/SpoIIIE family GO:0007186//GO:0017004//GO:0015684//GO:0007165//GO:0007264//GO:0015886 G-protein coupled receptor signaling pathway//cytochrome complex assembly//ferrous iron transport//signal transduction//small GTPase mediated signal transduction//heme transport GO:0000166//GO:0019001//GO:0005524//GO:0031683//GO:0003924//GO:0005525//GO:0004871//GO:0015093//GO:0003677 nucleotide binding//guanyl nucleotide binding//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//signal transducer activity//ferrous iron transmembrane transporter activity//DNA binding GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.37478 BF_2 12106.87 206.31 2742 765527267 AJS10722.1 1235 1.1e-132 14-3-3 zeta [Tenebrio molitor] 642911747 XM_008202503.1 574 0 PREDICTED: Tribolium castaneum 14-3-3 protein zeta (LOC660150), mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 1149 4.3e-124 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF17098 Pre-mRNA-splicing regulator WTAP GO:0048024 regulation of mRNA splicing, via spliceosome -- -- GO:0005634 nucleus -- -- Cluster-8309.37480 BF_2 2966.69 64.51 2211 332373744 AEE62013.1 291 2.6e-23 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5EF78 135 1.3e-06 Icarapin OS=Apis mellifera carnica PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37481 BF_2 490.71 8.25 2774 91081545 XP_974976.1 1293 2.1e-139 PREDICTED: calumenin [Tribolium castaneum]>gi|270006175|gb|EFA02623.1| hypothetical protein TcasGA2_TC008343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RDD8 880 6.7e-93 Calumenin OS=Pongo abelii GN=CALU PE=2 SV=1 PF13202//PF08707//PF00036//PF10591//PF13833//PF13405//PF13499 EF hand//Primase C terminal 2 (PriCT-2)//EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0016817//GO:0005509 hydrolase activity, acting on acid anhydrides//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.37482 BF_2 13996.03 196.61 3265 91077504 XP_966852.1 2795 0.0e+00 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 409 3.3e-38 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184//PF02627 Saposin-like type B, region 1//Carboxymuconolactone decarboxylase family GO:0055114//GO:0006629 oxidation-reduction process//lipid metabolic process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.37483 BF_2 189.19 2.63 3292 270001532 EEZ97979.1 2481 4.4e-277 hypothetical protein TcasGA2_TC000374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61627 319 9.0e-28 Glutamate receptor ionotropic, delta-1 OS=Mus musculus GN=Grid1 PE=1 SV=2 PF07826//PF10613//PF00060 IMP cyclohydrolase-like protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006164//GO:0007268//GO:0006144//GO:0006188//GO:0007165//GO:0006811//GO:0006807 purine nucleotide biosynthetic process//synaptic transmission//purine nucleobase metabolic process//IMP biosynthetic process//signal transduction//ion transport//nitrogen compound metabolic process GO:0005234//GO:0004970//GO:0003937 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//IMP cyclohydrolase activity GO:0016020//GO:0042720 membrane//mitochondrial inner membrane peptidase complex -- -- Cluster-8309.37484 BF_2 217.37 1.39 6825 642921666 XP_008192914.1 2161 1.2e-239 PREDICTED: polycomb protein Asx isoform X1 [Tribolium castaneum]>gi|270007351|gb|EFA03799.1| hypothetical protein TcasGA2_TC013912 [Tribolium castaneum] -- -- -- -- -- K11471 ASXL additional sex combs-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11471 Q9V727 566 4.3e-56 Polycomb protein Asx OS=Drosophila melanogaster GN=Asx PE=1 SV=1 PF12515//PF13922 Ca2+-ATPase N terminal autoinhibitory domain//PHD domain of transcriptional enhancer, Asx -- -- GO:0003677//GO:0005516 DNA binding//calmodulin binding -- -- -- -- Cluster-8309.37485 BF_2 169.90 5.50 1579 91093477 XP_968017.1 1493 7.7e-163 PREDICTED: U5 small nuclear ribonucleoprotein 40 kDa protein [Tribolium castaneum]>gi|270012667|gb|EFA09115.1| hypothetical protein TcasGA2_TC015975 [Tribolium castaneum] -- -- -- -- -- K12857 SNRNP40, PRP8BP Prp8 binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K12857 Q96DI7 1150 1.9e-124 U5 small nuclear ribonucleoprotein 40 kDa protein OS=Homo sapiens GN=SNRNP40 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0265 U5 snRNP-specific protein-like factor and related proteins Cluster-8309.37487 BF_2 2720.62 56.85 2289 270016491 EFA12937.1 319 1.5e-26 hypothetical protein TcasGA2_TC010484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43422 178 1.4e-11 52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens GN=PRKRIR PE=1 SV=2 PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.37489 BF_2 125.37 0.98 5640 642934848 XP_008197836.1 1638 4.2e-179 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.82509e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA -- -- -- -- Q5JR59 239 2.9e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37490 BF_2 643.08 72.15 660 805809799 XP_012146944.1 608 1.3e-60 PREDICTED: uncharacterized protein LOC100882817 isoform X1 [Megachile rotundata] -- -- -- -- -- -- -- -- -- O16264 476 1.1e-46 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.37491 BF_2 14.77 0.44 1703 546672637 ERL84433.1 1024 2.0e-108 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5YCC5 398 3.2e-37 Transmembrane channel-like protein 7 OS=Gallus gallus GN=Tmc7 PE=2 SV=1 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.37492 BF_2 331.00 9.72 1711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37493 BF_2 962.56 25.31 1878 728417130 AIY68334.1 1251 1.1e-134 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 599 1.7e-60 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.37494 BF_2 590.38 5.30 4950 385199910 AFI45003.1 524 5.6e-50 chemosensory protein [Dendroctonus ponderosae]>gi|478257941|gb|ENN78079.1| hypothetical protein YQE_05233, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27757 438 2.2e-41 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF03283//PF05924//PF00501 Pectinacetylesterase//SAMP Motif//AMP-binding enzyme GO:0016055//GO:0008152 Wnt signaling pathway//metabolic process GO:0016787//GO:0008013//GO:0003824 hydrolase activity//beta-catenin binding//catalytic activity GO:0016342 catenin complex -- -- Cluster-8309.37495 BF_2 1357.15 14.06 4324 270001798 EEZ98245.1 3596 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 469 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q10057 146 1.4e-07 Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F5.02 PE=3 SV=1 PF00085//PF02382//PF02020//PF01791 Thioredoxin//RTX N-terminal domain//eIF4-gamma/eIF5/eIF2-epsilon//DeoC/LacD family aldolase GO:0009405//GO:0045454 pathogenesis//cell redox homeostasis GO:0005509//GO:0005515//GO:0016829 calcium ion binding//protein binding//lyase activity GO:0005576 extracellular region KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.37497 BF_2 1506.00 49.97 1548 646705124 KDR13003.1 1380 9.6e-150 Serine-threonine kinase receptor-associated protein [Zootermopsis nevadensis] -- -- -- -- -- K13137 STRAP, UNRIP serine-threonine kinase receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K13137 Q5ZL33 1065 1.3e-114 Serine-threonine kinase receptor-associated protein OS=Gallus gallus GN=STRAP PE=2 SV=2 PF06433//PF00400 Methylamine dehydrogenase heavy chain (MADH)//WD domain, G-beta repeat GO:0015947//GO:0055114 methane metabolic process//oxidation-reduction process GO:0030058//GO:0005515 amine dehydrogenase activity//protein binding GO:0042597 periplasmic space KOG0278 Serine/threonine kinase receptor-associated protein Cluster-8309.37498 BF_2 481.50 9.11 2499 642926721 XP_008194985.1 1684 8.7e-185 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 564 2.7e-56 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.37499 BF_2 56.61 0.67 3805 642932100 XP_008196854.1 1535 2.5e-167 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.25272e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.9e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF07525//PF00622//PF01213 SOCS box//SPRY domain//Adenylate cyclase associated (CAP) N terminal GO:0007010//GO:0035556 cytoskeleton organization//intracellular signal transduction GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.37501 BF_2 53.28 0.90 2773 546674950 ERL86223.1 2101 4.3e-233 hypothetical protein D910_03634 [Dendroctonus ponderosae] 768419811 XM_011552337.1 225 1.05084e-111 PREDICTED: Plutella xylostella NADP-dependent malic enzyme (LOC105382451), transcript variant X3, mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1601 1.7e-176 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF03949//PF00390 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006090//GO:0015976//GO:0006099//GO:0055114//GO:0006108 pyruvate metabolic process//carbon utilization//tricarboxylic acid cycle//oxidation-reduction process//malate metabolic process GO:0004471//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.37502 BF_2 487.77 3.45 6193 345483040 XP_003424731.1 2293 5.2e-255 PREDICTED: poly [ADP-ribose] polymerase [Nasonia vitripennis] 505789579 XM_004605427.1 81 2.64723e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 1735 1.1e-191 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00646//PF08063//PF00644//PF02877//PF00645 F-box domain//PADR1 (NUC008) domain//Poly(ADP-ribose) polymerase catalytic domain//Poly(ADP-ribose) polymerase, regulatory domain//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0006471 protein ADP-ribosylation GO:0003950//GO:0005515//GO:0008270//GO:0003677 NAD+ ADP-ribosyltransferase activity//protein binding//zinc ion binding//DNA binding GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.37506 BF_2 34.40 0.85 1971 820805536 AKG92759.1 682 1.1e-68 nautilus [Leptinotarsa decemlineata] 31544201 AY154744.2 71 3.01602e-26 Branchiostoma floridae myogenic regulatory factor 1 (MRF1) mRNA, complete cds K18485 MYF6, MRF4 myogenic factor 6 http://www.genome.jp/dbget-bin/www_bget?ko:K18485 Q00492 276 5.2e-23 Transcription factor SUM-1 OS=Lytechinus variegatus GN=SUM-1 PE=2 SV=1 PF01586//PF00010 Myogenic Basic domain//Helix-loop-helix DNA-binding domain GO:0007517//GO:0006355 muscle organ development//regulation of transcription, DNA-templated GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005634 nucleus KOG3960 Myogenic helix-loop-helix transcription factor Cluster-8309.37508 BF_2 347.56 10.23 1708 91090210 XP_967762.1 1293 1.3e-139 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P09875 506 9.7e-50 UDP-glucuronosyltransferase 2B1 OS=Rattus norvegicus GN=Ugt2b1 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758//GO:0016757 transferase activity, transferring hexosyl groups//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.37509 BF_2 296.23 5.99 2355 189236600 XP_001816436.1 1585 2.5e-173 PREDICTED: sensory neuron membrane protein 1 [Tribolium castaneum]>gi|332321724|sp|D2A0H5.1|SNMP1_TRICA RecName: Full=Sensory neuron membrane protein 1 [Tribolium castaneum]>gi|270006451|gb|EFA02899.1| sensory neuron membrane protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2A0H5 1585 1.0e-174 Sensory neuron membrane protein 1 OS=Tribolium castaneum GN=SNMP01 PE=3 SV=1 PF01130 CD36 family GO:0007155//GO:0044699 cell adhesion//single-organism process -- -- GO:0016020 membrane -- -- Cluster-8309.3751 BF_2 5.00 0.49 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37512 BF_2 866.92 17.10 2408 642921190 XP_008192754.1 999 2.3e-105 PREDICTED: reticulon-1-A-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 482 8.3e-47 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF00834 Ribulose-phosphate 3 epimerase family GO:0005975 carbohydrate metabolic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG1792 Reticulon Cluster-8309.37513 BF_2 51.95 0.68 3499 642921186 XP_008192751.1 809 3.5e-83 PREDICTED: reticulon-1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 460 4.3e-44 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF00834//PF01442 Ribulose-phosphate 3 epimerase family//Apolipoprotein A1/A4/E domain GO:0005975//GO:0006869//GO:0042157 carbohydrate metabolic process//lipid transport//lipoprotein metabolic process GO:0016857//GO:0008289 racemase and epimerase activity, acting on carbohydrates and derivatives//lipid binding GO:0005576 extracellular region KOG1792 Reticulon Cluster-8309.37514 BF_2 598.40 8.65 3181 91085723 XP_973304.1 1054 1.2e-111 PREDICTED: [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Tribolium castaneum]>gi|270010109|gb|EFA06557.1| hypothetical protein TcasGA2_TC009468 [Tribolium castaneum] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 713 1.8e-73 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 PF00942 Cellulose binding domain GO:0005975 carbohydrate metabolic process GO:0030248//GO:0005524 cellulose binding//ATP binding -- -- KOG0787 Dehydrogenase kinase Cluster-8309.37515 BF_2 1780.30 56.94 1595 573896974 XP_006636225.1 161 2.2e-08 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- O54819 145 6.5e-08 Tissue factor pathway inhibitor OS=Mus musculus GN=Tfpi PE=2 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.37517 BF_2 3174.47 12.83 10641 270001100 EEZ97547.1 2545 5.4e-284 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] 170032990 XM_001844311.1 225 4.07003e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 9.8e-217 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF00595//PF14304//PF13855//PF00412//PF13180//PF10468//PF00560//PF01378 PDZ domain (Also known as DHR or GLGF)//Transcription termination and cleavage factor C-terminal//Leucine rich repeat//LIM domain//PDZ domain//Carboxypeptidase inhibitor I68//Leucine Rich Repeat//B domain GO:0031124//GO:0007596//GO:0010951 mRNA 3'-end processing//blood coagulation//negative regulation of endopeptidase activity GO:0008191//GO:0008270//GO:0005515 metalloendopeptidase inhibitor activity//zinc ion binding//protein binding GO:0005618 cell wall KOG0619 FOG: Leucine rich repeat Cluster-8309.37519 BF_2 91.12 1.25 3331 642915176 XP_008190506.1 292 3.0e-23 PREDICTED: uncharacterized protein LOC103312210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37520 BF_2 1027.26 22.67 2183 189235991 XP_972419.2 922 1.7e-96 PREDICTED: dnaJ homolog subfamily B member 14 [Tribolium castaneum] -- -- -- -- -- K09518 DNAJB12 DnaJ homolog subfamily B member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09518 Q9NXW2 372 4.3e-34 DnaJ homolog subfamily B member 12 OS=Homo sapiens GN=DNAJB12 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.37521 BF_2 169.72 1.89 4045 642927864 XP_008195430.1 2314 1.2e-257 PREDICTED: inhibitor of Bruton tyrosine kinase [Tribolium castaneum]>gi|270010253|gb|EFA06701.1| hypothetical protein TcasGA2_TC009632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPR6 1063 5.9e-114 Inhibitor of Bruton tyrosine kinase OS=Mus musculus GN=Ibtk PE=1 SV=3 PF00023//PF00651//PF13606//PF05224 Ankyrin repeat//BTB/POZ domain//Ankyrin repeat//NDT80 / PhoG like DNA-binding family -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0783 Uncharacterized conserved protein, contains ankyrin and BTB/POZ domains Cluster-8309.37522 BF_2 4953.26 17.99 11802 642917812 XP_008191295.1 7401 0.0e+00 PREDICTED: ankyrin-3-like isoform X3 [Tribolium castaneum] 801371747 XM_012207187.1 386 0 PREDICTED: Atta cephalotes uncharacterized LOC105625877 (LOC105625877), mRNA K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 4153 0.0e+00 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF04277//PF13606//PF00531//PF01442//PF00023 Oxaloacetate decarboxylase, gamma chain//Ankyrin repeat//Death domain//Apolipoprotein A1/A4/E domain//Ankyrin repeat GO:0071436//GO:0006090//GO:0006814//GO:0042157//GO:0006525//GO:0007165//GO:0006560//GO:0006869 sodium ion export//pyruvate metabolic process//sodium ion transport//lipoprotein metabolic process//arginine metabolic process//signal transduction//proline metabolic process//lipid transport GO:0015081//GO:0008289//GO:0005515//GO:0008948 sodium ion transmembrane transporter activity//lipid binding//protein binding//oxaloacetate decarboxylase activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.37524 BF_2 74.00 4.28 1010 557876145 AHA39267.1 342 1.4e-29 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- Q27018 152 6.4e-09 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.37525 BF_2 1754.00 54.48 1634 546675887 ERL86992.1 2177 3.9e-242 hypothetical protein D910_04395 [Dendroctonus ponderosae] 827557709 XM_004930962.2 230 1.02038e-114 PREDICTED: Bombyx mori probable 26S proteasome non-ATPase regulatory subunit 3 (LOC101746211), mRNA K03033 PSMD3, RPN3 26S proteasome regulatory subunit N3 http://www.genome.jp/dbget-bin/www_bget?ko:K03033 O61470 1775 6.6e-197 Probable 26S proteasome non-ATPase regulatory subunit 3 OS=Anopheles gambiae GN=Dox-A2 PE=3 SV=2 PF08375//PF07503//PF01399 Proteasome regulatory subunit C-terminal//HypF finger//PCI domain GO:0042176 regulation of protein catabolic process GO:0008270//GO:0030234//GO:0005515 zinc ion binding//enzyme regulator activity//protein binding GO:0000502 proteasome complex KOG2581 26S proteasome regulatory complex, subunit RPN3/PSMD3 Cluster-8309.37528 BF_2 676.20 9.76 3186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37529 BF_2 6274.85 132.31 2271 91077138 XP_971446.1 1715 2.0e-188 PREDICTED: dnaJ homolog subfamily A member 1 [Tribolium castaneum]>gi|270001716|gb|EEZ98163.1| hypothetical protein TcasGA2_TC000590 [Tribolium castaneum] 817197334 XM_012418859.1 190 2.45621e-92 PREDICTED: Orussus abietinus dnaJ homolog subfamily A member 1 (LOC105696421), transcript variant X2, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 Q5E954 1351 1.3e-147 DnaJ homolog subfamily A member 1 OS=Bos taurus GN=DNAJA1 PE=2 SV=2 PF16685//PF01155//PF00684 zinc RING finger of MSL2//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//DnaJ central domain GO:0006260//GO:0009408//GO:0006457//GO:0006464 DNA replication//response to heat//protein folding//cellular protein modification process GO:0046872//GO:0051082//GO:0016151//GO:0061630//GO:0031072//GO:0005524 metal ion binding//unfolded protein binding//nickel cation binding//ubiquitin protein ligase activity//heat shock protein binding//ATP binding GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.37530 BF_2 476.02 2.38 8637 91079160 XP_967064.1 4270 0.0e+00 PREDICTED: E3 SUMO-protein ligase RanBP2 [Tribolium castaneum]>gi|270003619|gb|EFA00067.1| hypothetical protein TcasGA2_TC002881 [Tribolium castaneum] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 371 2.2e-33 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF06810//PF04513//PF09177//PF00641//PF00638 Phage minor structural protein GP20//Baculovirus polyhedron envelope protein, PEP, C terminus//Syntaxin 6, N-terminal//Zn-finger in Ran binding protein and others//RanBP1 domain GO:0048193//GO:0046907 Golgi vesicle transport//intracellular transport GO:0008270//GO:0005198 zinc ion binding//structural molecule activity GO:0019028//GO:0016020//GO:0019031 viral capsid//membrane//viral envelope KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.37531 BF_2 1907.61 8.79 9365 91079160 XP_967064.1 5066 0.0e+00 PREDICTED: E3 SUMO-protein ligase RanBP2 [Tribolium castaneum]>gi|270003619|gb|EFA00067.1| hypothetical protein TcasGA2_TC002881 [Tribolium castaneum] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 495 1.0e-47 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF00638//PF13181//PF06810//PF13371//PF00641//PF00515//PF13414//PF13176 RanBP1 domain//Tetratricopeptide repeat//Phage minor structural protein GP20//Tetratricopeptide repeat//Zn-finger in Ran binding protein and others//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0046907 intracellular transport GO:0005198//GO:0005515//GO:0008270 structural molecule activity//protein binding//zinc ion binding -- -- KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.37532 BF_2 637.88 3.54 7828 189241221 XP_001812199.1 1072 2.5e-113 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 749 2.9e-77 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF06008//PF00246//PF04977//PF05531//PF16326//PF04952//PF07544//PF00018//PF01166 Laminin Domain I//Zinc carboxypeptidase//Septum formation initiator//Nucleopolyhedrovirus P10 protein//ABC transporter C-terminal domain//Succinylglutamate desuccinylase / Aspartoacylase family//RNA polymerase II transcription mediator complex subunit 9//SH3 domain//TSC-22/dip/bun family GO:0008152//GO:0006508//GO:0030155//GO:0030334//GO:0007165//GO:0006357//GO:0006355//GO:0045995//GO:0007049 metabolic process//proteolysis//regulation of cell adhesion//regulation of cell migration//signal transduction//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//regulation of embryonic development//cell cycle GO:0001104//GO:0003677//GO:0016788//GO:0005515//GO:0005102//GO:0008270//GO:0004181//GO:0003700 RNA polymerase II transcription cofactor activity//DNA binding//hydrolase activity, acting on ester bonds//protein binding//receptor binding//zinc ion binding//metallocarboxypeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0016592//GO:0005667//GO:0019028 mediator complex//transcription factor complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.37533 BF_2 305.89 4.45 3165 91084647 XP_966816.1 2399 1.4e-267 PREDICTED: carboxypeptidase D [Tribolium castaneum] -- -- -- -- -- K07752 CPD carboxypeptidase D http://www.genome.jp/dbget-bin/www_bget?ko:K07752 P42787 1299 2.0e-141 Carboxypeptidase D OS=Drosophila melanogaster GN=svr PE=1 SV=2 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.37536 BF_2 1968.81 9.54 8920 642918470 XP_008191489.1 1571 3.9e-171 PREDICTED: protein NDRG3 isoform X2 [Tribolium castaneum] 462464055 APGK01005064.1 69 1.789e-24 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 8.6e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.37537 BF_2 141.74 3.44 2010 642917810 XP_008191294.1 2849 0.0e+00 PREDICTED: ankyrin-3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q01484 2167 2.8e-242 Ankyrin-2 OS=Homo sapiens GN=ANK2 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.37538 BF_2 2880.59 142.97 1130 642913599 XP_008201080.1 343 1.2e-29 PREDICTED: extensin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37540 BF_2 60.26 0.58 4609 642918982 XP_008191684.1 4721 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.43632e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF05109//PF00122 Herpes virus major outer envelope glycoprotein (BLLF1)//E1-E2 ATPase GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.37542 BF_2 1811.56 22.35 3678 91078104 XP_972867.1 1786 1.9e-196 PREDICTED: spondin-2 isoform X1 [Tribolium castaneum] 642914951 XM_967774.3 433 0 PREDICTED: Tribolium castaneum spondin-2 (LOC661624), transcript variant X1, mRNA -- -- -- -- Q9WV75 510 7.2e-50 Spondin-2 OS=Rattus norvegicus GN=Spon2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.37543 BF_2 249.03 4.59 2558 642934689 XP_972767.2 3035 0.0e+00 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 D3ZGS3 1477 3.7e-162 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Rattus norvegicus GN=Ocrl PE=1 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.37544 BF_2 59.51 0.44 5922 642923755 XP_008193870.1 936 1.1e-97 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X2 [Tribolium castaneum]>gi|270006935|gb|EFA03383.1| hypothetical protein TcasGA2_TC013369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 1.3e-56 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- GO:0051302//GO:0051726//GO:0045859 regulation of cell division//regulation of cell cycle//regulation of protein kinase activity GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.37545 BF_2 203.78 1.55 5779 91092690 XP_971771.1 1827 5.3e-201 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 6.35138e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 941 1.2e-99 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.37550 BF_2 226.72 7.47 1557 211939884 ACJ13424.1 872 7.8e-91 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- P80034 579 3.0e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37551 BF_2 12059.58 276.60 2111 642940096 XP_008192965.1 1240 2.2e-133 PREDICTED: paxillin isoform X6 [Tribolium castaneum]>gi|270016014|gb|EFA12462.1| hypothetical protein TcasGA2_TC010609 [Tribolium castaneum] 665811408 XM_008555945.1 200 6.2958e-98 PREDICTED: Microplitis demolitor leupaxin-like (LOC103575940), mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49024 831 2.5e-87 Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1 PF01258//PF00412 Prokaryotic dksA/traR C4-type zinc finger//LIM domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.37552 BF_2 51.13 0.53 4361 642914862 XP_008195074.1 2187 7.2e-243 PREDICTED: myosin light chain kinase, smooth muscle-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q6PDN3 828 1.1e-86 Myosin light chain kinase, smooth muscle OS=Mus musculus GN=Mylk PE=1 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37554 BF_2 326.30 1.12 12506 189238427 XP_973569.2 3930 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase DHX34 [Tribolium castaneum]>gi|270008523|gb|EFA04971.1| hypothetical protein TcasGA2_TC015049 [Tribolium castaneum] 642925354 XM_008196294.1 497 0 PREDICTED: Tribolium castaneum integrator complex subunit 2 (LOC661595), mRNA K13139 INTS2 integrator complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13139 Q14147 2048 1.1e-227 Probable ATP-dependent RNA helicase DHX34 OS=Homo sapiens GN=DHX34 PE=1 SV=2 PF07527//PF00270//PF14750//PF04851//PF03391//PF00023//PF02399//PF04408//PF13606 Hairy Orange//DEAD/DEAH box helicase//Integrator complex subunit 2//Type III restriction enzyme, res subunit//Nepovirus coat protein, central domain//Ankyrin repeat//Origin of replication binding protein//Helicase associated domain (HA2)//Ankyrin repeat GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003676//GO:0005198//GO:0008026//GO:0005515//GO:0005524//GO:0003688//GO:0004386//GO:0003677//GO:0016787 nucleic acid binding//structural molecule activity//ATP-dependent helicase activity//protein binding//ATP binding//DNA replication origin binding//helicase activity//DNA binding//hydrolase activity GO:0046809//GO:0019028//GO:0032039 replication compartment//viral capsid//integrator complex -- -- Cluster-8309.37555 BF_2 79.65 0.61 5727 642926029 XP_969555.3 1435 1.5e-155 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 4.18231e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 3.5e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 PF05456 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) GO:0045947 negative regulation of translational initiation GO:0008190 eukaryotic initiation factor 4E binding -- -- -- -- Cluster-8309.37556 BF_2 9687.19 41.69 10008 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF03884//PF01601//PF14634//PF00097//PF08165//PF01436//PF00651//PF04513//PF13639//PF04566//PF10588 Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//FerA (NUC095) domain//NHL repeat//BTB/POZ domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114//GO:0006351//GO:0006144//GO:0061025//GO:0006206//GO:0046813 oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process//membrane fusion//pyrimidine nucleobase metabolic process//receptor-mediated virion attachment to host cell GO:0003899//GO:0005198//GO:0008270//GO:0003677//GO:0005515//GO:0016491//GO:0046872 DNA-directed RNA polymerase activity//structural molecule activity//zinc ion binding//DNA binding//protein binding//oxidoreductase activity//metal ion binding GO:0016021//GO:0019028//GO:0005730//GO:0019031 integral component of membrane//viral capsid//nucleolus//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37559 BF_2 2479.82 14.34 7521 642924959 XP_008194115.1 2881 0.0e+00 PREDICTED: coiled-coil domain-containing protein CG32809 isoform X7 [Tribolium castaneum] 642924968 XM_008195898.1 229 1.71662e-113 PREDICTED: Tribolium castaneum coiled-coil domain-containing protein AGAP005037 (LOC100141714), transcript variant X12, mRNA -- -- -- -- Q7PQ25 1217 1.5e-131 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF07989//PF02970//PF07945//PF01025 Centrosomin N-terminal motif 1//Tubulin binding cofactor A//Janus-atracotoxin//GrpE GO:0009405//GO:0006457//GO:0007021 pathogenesis//protein folding//tubulin complex assembly GO:0015631//GO:0051087//GO:0042803//GO:0051082//GO:0000774 tubulin binding//chaperone binding//protein homodimerization activity//unfolded protein binding//adenyl-nucleotide exchange factor activity GO:0045298//GO:0005815//GO:0005576 tubulin complex//microtubule organizing center//extracellular region -- -- Cluster-8309.37560 BF_2 1422.10 42.74 1679 478255276 ENN75505.1 1901 4.0e-210 hypothetical protein YQE_08054, partial [Dendroctonus ponderosae]>gi|546677636|gb|ERL88437.1| hypothetical protein D910_05823 [Dendroctonus ponderosae] -- -- -- -- -- K02358 tuf, TUFM elongation factor Tu http://www.genome.jp/dbget-bin/www_bget?ko:K02358 P49411 1336 5.4e-146 Elongation factor Tu, mitochondrial OS=Homo sapiens GN=TUFM PE=1 SV=2 PF03144//PF01926//PF10662 Elongation factor Tu domain 2//50S ribosome-binding GTPase//Ethanolamine utilisation - propanediol utilisation GO:0006576 cellular biogenic amine metabolic process GO:0005524//GO:0005525 ATP binding//GTP binding -- -- KOG0460 Mitochondrial translation elongation factor Tu Cluster-8309.37561 BF_2 219.98 1.11 8551 642911061 XP_008200558.1 3908 0.0e+00 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2982 0.0e+00 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00520//PF00813 Ion transport protein//FliP family GO:0006811//GO:0009306//GO:0055085 ion transport//protein secretion//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.37562 BF_2 9.00 0.57 951 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37564 BF_2 270.72 13.28 1140 642937205 XP_008198739.1 1105 5.5e-118 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12549 Tyrosine hydroxylase N terminal GO:0055114//GO:0006570 oxidation-reduction process//tyrosine metabolic process GO:0004511 tyrosine 3-monooxygenase activity -- -- -- -- Cluster-8309.37565 BF_2 1730.94 22.64 3485 642928992 XP_008195647.1 1707 2.6e-187 PREDICTED: endoplasmic reticulum metallopeptidase 1-like [Tribolium castaneum] 642930260 XM_966256.3 107 5.2215e-46 PREDICTED: Tribolium castaneum 40S ribosomal protein S29 (LOC659992), mRNA -- -- -- -- Q3UVK0 775 1.3e-80 Endoplasmic reticulum metallopeptidase 1 OS=Mus musculus GN=Ermp1 PE=2 SV=2 PF15168//PF00253//PF01546 Triple QxxK/R motif-containing protein family//Ribosomal protein S14p/S29e//Peptidase family M20/M25/M40 GO:0042254//GO:0008152//GO:0006412 ribosome biogenesis//metabolic process//translation GO:0003735//GO:0016787 structural constituent of ribosome//hydrolase activity GO:0005840//GO:0005622//GO:0005789 ribosome//intracellular//endoplasmic reticulum membrane KOG2194 Aminopeptidases of the M20 family Cluster-8309.37566 BF_2 63.97 0.44 6303 847542679 CDI30232.1 3007 0.0e+00 Insulin Receptor [Blattella germanica] 887513390 KP331063.1 128 2.00965e-57 Leptinotarsa decemlineata insulin-like receptor (INR) mRNA, complete cds K05086 INSRR insulin receptor-related receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05086 P14617 2072 9.2e-231 Insulin receptor-related protein OS=Cavia porcellus GN=INSRR PE=3 SV=1 PF00069//PF07714//PF16656//PF00757//PF00041 Protein kinase domain//Protein tyrosine kinase//Purple acid Phosphatase, N-terminal domain//Furin-like cysteine rich region//Fibronectin type III domain GO:0019497//GO:0006468//GO:0007169//GO:0006771 hexachlorocyclohexane metabolic process//protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway//riboflavin metabolic process GO:0005515//GO:0005524//GO:0004714//GO:0046872//GO:0004672//GO:0003993 protein binding//ATP binding//transmembrane receptor protein tyrosine kinase activity//metal ion binding//protein kinase activity//acid phosphatase activity GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.37567 BF_2 5.28 0.65 627 642914876 XP_008190427.1 317 7.1e-27 PREDICTED: tropomyosin alpha-1 chain [Tribolium castaneum]>gi|270001406|gb|EEZ97853.1| hypothetical protein TcasGA2_TC000225 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37568 BF_2 193.74 3.56 2566 91077460 XP_967961.1 1258 2.2e-135 PREDICTED: membrane-bound transcription factor site-2 protease [Tribolium castaneum]>gi|270001616|gb|EEZ98063.1| hypothetical protein TcasGA2_TC000469 [Tribolium castaneum] -- -- -- -- -- K07765 MBTPS2 S2P endopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K07765 O54862 544 5.7e-54 Membrane-bound transcription factor site-2 protease OS=Cricetulus griseus GN=MBTPS2 PE=2 SV=1 PF13180//PF02163 PDZ domain//Peptidase family M50 GO:0006508 proteolysis GO:0004222//GO:0005515 metalloendopeptidase activity//protein binding -- -- KOG2921 Intramembrane metalloprotease (sterol-regulatory element-binding protein (SREBP) protease) Cluster-8309.37569 BF_2 88.60 1.52 2727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09207 Yeast killer toxin GO:0009405//GO:0008219 pathogenesis//cell death -- -- GO:0005576 extracellular region -- -- Cluster-8309.37572 BF_2 554.29 8.81 2920 642929338 XP_008195792.1 700 1.3e-70 PREDICTED: AMP deaminase 2 isoform X3 [Tribolium castaneum] 194769475 XM_001966794.1 153 1.17176e-71 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 449 6.7e-43 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0019239 metal ion binding//oxidoreductase activity//deaminase activity -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.37576 BF_2 17873.86 170.95 4661 270012529 EFA08977.1 860 5.7e-89 hypothetical protein TcasGA2_TC006684 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37577 BF_2 69.54 0.38 7938 642925217 XP_008194472.1 2663 8.3e-298 PREDICTED: zinc finger protein 729-like isoform X1 [Tribolium castaneum]>gi|270008760|gb|EFA05208.1| hypothetical protein TcasGA2_TC015347 [Tribolium castaneum] 194761711 XM_001963036.1 87 1.56887e-34 Drosophila ananassae GF15759 (Dana\GF15759), mRNA -- -- -- -- Q9VL13 907 1.4e-95 MOB kinase activator-like 3 OS=Drosophila melanogaster GN=Mob3 PE=2 SV=1 PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus KOG1903 Cell cycle-associated protein Cluster-8309.37578 BF_2 1693.00 11.96 6209 642926098 XP_008194783.1 7192 0.0e+00 PREDICTED: uncharacterized protein KIAA1109 [Tribolium castaneum] 194758979 XM_001961698.1 57 5.82701e-18 Drosophila ananassae GF14780 (Dana\GF14780), mRNA -- -- -- -- Q2LD37 1686 5.2e-186 Uncharacterized protein KIAA1109 OS=Homo sapiens GN=KIAA1109 PE=1 SV=2 PF04444 Catechol dioxygenase N terminus GO:0046232//GO:0055114//GO:0042184//GO:0042203//GO:0009712//GO:0019261//GO:0018874 carbazole catabolic process//oxidation-reduction process//xylene catabolic process//toluene catabolic process//catechol-containing compound metabolic process//1,4-dichlorobenzene catabolic process//benzoate metabolic process GO:0005506//GO:0018576 iron ion binding//catechol 1,2-dioxygenase activity -- -- KOG3596 Uncharacterized conserved protein Cluster-8309.37579 BF_2 71.00 8.16 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF08496 Presenilin//Peptidase family S49 N-terminal -- -- GO:0004252//GO:0004190 serine-type endopeptidase activity//aspartic-type endopeptidase activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.37580 BF_2 48.15 0.32 6646 332373456 AEE61869.1 1731 8.2e-190 unknown [Dendroctonus ponderosae]>gi|478257157|gb|ENN77320.1| hypothetical protein YQE_06146, partial [Dendroctonus ponderosae] 701345709 XM_009975740.1 83 2.19598e-32 PREDICTED: Tyto alba UDP-glucuronic acid decarboxylase 1 (LOC104368417), partial mRNA K08678 UXS1, uxs UDP-glucuronate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K08678 Q6DF08 1329 1.4e-144 UDP-glucuronic acid decarboxylase 1 OS=Xenopus tropicalis GN=uxs1 PE=2 SV=1 PF01073//PF00293//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NUDIX domain//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008210//GO:0008152//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0016787//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//hydrolase activity//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase Cluster-8309.37581 BF_2 5115.97 502.56 713 264667389 ACY71280.1 925 2.5e-97 ribosomal protein S7 [Chrysomela tremula] 752878389 XM_011258375.1 129 6.06055e-59 PREDICTED: Camponotus floridanus 40S ribosomal protein S7-like (LOC105251512), mRNA K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 Q962S0 854 1.8e-90 40S ribosomal protein S7 OS=Spodoptera frugiperda GN=RpS7 PE=2 SV=1 PF01251 Ribosomal protein S7e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3320 40S ribosomal protein S7 Cluster-8309.37582 BF_2 1548.00 75.93 1140 91075924 XP_966963.1 279 3.3e-22 PREDICTED: cytochrome b-c1 complex subunit 10 [Tribolium castaneum]>gi|270015124|gb|EFA11572.1| hypothetical protein TcasGA2_TC004680 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CPX8 140 1.8e-07 Cytochrome b-c1 complex subunit 10 OS=Mus musculus GN=Uqcr11 PE=3 SV=1 PF08997 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0006118//GO:0006119//GO:0015992 obsolete electron transport//oxidative phosphorylation//proton transport GO:0009055//GO:0008121 electron carrier activity//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.37583 BF_2 3574.74 22.05 7068 642935886 XP_008198213.1 3884 0.0e+00 PREDICTED: sterile alpha and TIR motif-containing protein 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IDD9 2791 0.0e+00 Sterile alpha and TIR motif-containing protein 1 OS=Drosophila melanogaster GN=Ect4 PE=2 SV=1 PF00514//PF06624//PF00536//PF07647//PF16045//PF13676 Armadillo/beta-catenin-like repeat//Ribosome associated membrane protein RAMP4//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//LisH//TIR domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005783 endoplasmic reticulum KOG3678 SARM protein (with sterile alpha and armadillo motifs) Cluster-8309.37585 BF_2 169.56 1.46 5156 332375044 AEE62663.1 3535 0.0e+00 unknown [Dendroctonus ponderosae]>gi|478250038|gb|ENN70544.1| hypothetical protein YQE_12719, partial [Dendroctonus ponderosae]>gi|546672620|gb|ERL84416.1| hypothetical protein D910_01849 [Dendroctonus ponderosae] 642932042 XM_969767.3 504 0 PREDICTED: Tribolium castaneum probable aconitate hydratase, mitochondrial (LOC663732), mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 Q99KI0 3035 0.0e+00 Aconitate hydratase, mitochondrial OS=Mus musculus GN=Aco2 PE=1 SV=1 PF00330//PF00694 Aconitase family (aconitate hydratase)//Aconitase C-terminal domain GO:0008152 metabolic process -- -- -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.37586 BF_2 4244.78 22.36 8228 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 1.7e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00448//PF01225//PF06414//PF13304//PF00005//PF03193 SRP54-type protein, GTPase domain//Mur ligase family, catalytic domain//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0006614//GO:0009058 SRP-dependent cotranslational protein targeting to membrane//biosynthetic process GO:0016301//GO:0016887//GO:0005525//GO:0005524//GO:0003924 kinase activity//ATPase activity//GTP binding//ATP binding//GTPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.37587 BF_2 195.55 0.98 8599 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 1.8e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF01225//PF00448//PF00005//PF03193//PF13304//PF06414 Mur ligase family, catalytic domain//SRP54-type protein, GTPase domain//ABC transporter//Protein of unknown function, DUF258//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin GO:0009058//GO:0006614 biosynthetic process//SRP-dependent cotranslational protein targeting to membrane GO:0003924//GO:0016301//GO:0016887//GO:0005525//GO:0005524 GTPase activity//kinase activity//ATPase activity//GTP binding//ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.37588 BF_2 159.71 1.11 6309 478249703 ENN70211.1 1984 3.6e-219 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05642 ABCA2 ATP-binding cassette, subfamily A (ABC1), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05642 Q9ESR9 982 2.3e-104 ATP-binding cassette sub-family A member 2 OS=Rattus norvegicus GN=Abca2 PE=1 SV=1 PF06414//PF13304//PF03193//PF00005//PF01312//PF01225 Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function, DUF258//ABC transporter//FlhB HrpN YscU SpaS Family//Mur ligase family, catalytic domain GO:0009306//GO:0009058 protein secretion//biosynthetic process GO:0003924//GO:0005524//GO:0005525//GO:0016301//GO:0016887 GTPase activity//ATP binding//GTP binding//kinase activity//ATPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.37590 BF_2 156.26 1.03 6648 675381743 KFM74645.1 363 3.5e-31 Zinc finger protein 729, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A0JNB1 314 6.9e-27 Zinc finger protein 227 OS=Bos taurus GN=ZNF227 PE=2 SV=1 PF13465//PF07535//PF04810//PF06305//PF00412//PF02892//PF13912//PF01428//PF16622//PF00096 Zinc-finger double domain//DBF zinc finger//Sec23/Sec24 zinc finger//Protein of unknown function (DUF1049)//LIM domain//BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0046872//GO:0003677 nucleic acid binding//zinc ion binding//metal ion binding//DNA binding GO:0005887//GO:0030127 integral component of plasma membrane//COPII vesicle coat -- -- Cluster-8309.37591 BF_2 56.29 1.30 2103 91092778 XP_973837.1 667 6.2e-67 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.37594 BF_2 138.32 0.87 6954 546679508 ERL89967.1 2307 1.4e-256 hypothetical protein D910_07326 [Dendroctonus ponderosae] 642937940 XM_001807052.2 505 0 PREDICTED: Tribolium castaneum sodium/hydrogen exchanger 8 (LOC100141996), mRNA K14724 SLC9A8, NHE8 solute carrier family 9 (sodium/hydrogen exchanger), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14724 Q5ZJ75 1410 5.9e-154 Sodium/hydrogen exchanger 8 OS=Gallus gallus PE=2 SV=1 PF00999//PF06699//PF02615 Sodium/hydrogen exchanger family//GPI biosynthesis protein family Pig-F//Malate/L-lactate dehydrogenase GO:0055085//GO:0008152//GO:0006506//GO:0006885//GO:0006812//GO:0055114 transmembrane transport//metabolic process//GPI anchor biosynthetic process//regulation of pH//cation transport//oxidation-reduction process GO:0015299//GO:0016491 solute:proton antiporter activity//oxidoreductase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.37596 BF_2 719.92 11.39 2932 91091818 XP_966528.1 2047 8.2e-227 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1305 3.7e-142 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF03594//PF02321//PF00060//PF10613 Benzoate membrane transport protein//Outer membrane efflux protein//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0006810//GO:0007268//GO:0042919//GO:0007165//GO:0006811 transport//synaptic transmission//benzoate transport//signal transduction//ion transport GO:0005234//GO:0004970//GO:0005215//GO:0042925//GO:0005216 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//transporter activity//benzoate transporter activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.37597 BF_2 4483.00 40.36 4934 270010525 EFA06973.1 577 4.0e-56 hypothetical protein TcasGA2_TC009933 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI6 341 3.8e-30 Transcription factor CP2-like protein 1 OS=Homo sapiens GN=TFCP2L1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37598 BF_2 6598.68 112.45 2742 189236107 XP_973934.2 817 3.3e-84 PREDICTED: high mobility group protein DSP1-like [Tribolium castaneum] 642918928 XM_968841.3 235 2.86828e-117 PREDICTED: Tribolium castaneum high mobility group protein DSP1-like (LOC662763), mRNA K10802 HMGB1 high mobility group protein B1 http://www.genome.jp/dbget-bin/www_bget?ko:K10802 Q24537 690 7.2e-71 High mobility group protein DSP1 OS=Drosophila melanogaster GN=Dsp1 PE=2 SV=1 PF15761//PF09606//PF04961 Immortalisation up-regulated protein//ARC105 or Med15 subunit of Mediator complex non-fungal//Formiminotransferase-cyclodeaminase GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0001104 catalytic activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005634 mediator complex//nucleus KOG0381 HMG box-containing protein Cluster-8309.37599 BF_2 540.00 8.72 2879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15245 Transcription cofactor vestigial-like protein 4 GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.37600 BF_2 209.27 0.66 13491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00770//PF05493 Adenovirus endoprotease//ATP synthase subunit H GO:0015992//GO:0015991//GO:0006508 proton transport//ATP hydrolysis coupled proton transport//proteolysis GO:0004197//GO:0015078 cysteine-type endopeptidase activity//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.37601 BF_2 438.41 8.82 2367 642929146 XP_008195713.1 1136 2.9e-121 PREDICTED: quaking related isoform X1 [Tribolium castaneum] -- -- -- -- -- K17843 KHDRBS2, SLM1 KH domain-containing, RNA-binding, signal transduction-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17843 Q920F3 502 3.9e-49 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Rattus norvegicus GN=Khdrbs2 PE=1 SV=1 PF13014//PF00013 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.37602 BF_2 14268.07 288.08 2359 240849263 NP_001155531.1 702 6.1e-71 V-type proton ATPase 16 kDa proteolipid subunit [Acyrthosiphon pisum]>gi|239790001|dbj|BAH71590.1| ACYPI003545 [Acyrthosiphon pisum] 642937690 XM_962866.3 207 9.05276e-102 PREDICTED: Tribolium castaneum V-type proton ATPase 16 kDa proteolipid subunit (LOC656327), mRNA K02155 ATPeV0C, ATP6L V-type H+-transporting ATPase 16kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02155 P23380 685 2.3e-70 V-type proton ATPase 16 kDa proteolipid subunit OS=Drosophila melanogaster GN=Vha16-1 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0016021//GO:0033177 proton-transporting V-type ATPase, V0 domain//integral component of membrane//proton-transporting two-sector ATPase complex, proton-transporting domain KOG0232 Vacuolar H+-ATPase V0 sector, subunits c/c' Cluster-8309.37603 BF_2 792.81 10.88 3335 642928315 XP_008195531.1 1039 7.2e-110 PREDICTED: microtubule-associated protein RP/EB family member 1 [Tribolium castaneum] 817062491 XM_012397482.1 89 5.06558e-36 PREDICTED: Athalia rosae microtubule-associated protein RP/EB family member 1 (LOC105684257), transcript variant X6, mRNA K10436 MAPRE microtubule-associated protein, RP/EB family http://www.genome.jp/dbget-bin/www_bget?ko:K10436 Q66T82 749 1.3e-77 Microtubule-associated protein RP/EB family member 1 OS=Coturnix coturnix japonica GN=MAPRE1 PE=2 SV=1 PF00307//PF03271//PF05361//PF06070 Calponin homology (CH) domain//EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor//Herpesvirus large structural phosphoprotein UL32 GO:0042325 regulation of phosphorylation GO:0008017//GO:0005198//GO:0005515 microtubule binding//structural molecule activity//protein binding GO:0005737//GO:0045298 cytoplasm//tubulin complex KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.37605 BF_2 9966.66 113.45 3962 546676342 ERL87369.1 868 5.8e-90 hypothetical protein D910_04764 [Dendroctonus ponderosae] -- -- -- -- -- K17987 NBR1 next to BRCA1 gene 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K17987 Q5RC94 190 9.8e-13 Next to BRCA1 gene 1 protein OS=Pongo abelii GN=NBR1 PE=2 SV=1 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.37607 BF_2 1365.31 42.47 1632 270016295 EFA12741.1 1660 3.4e-182 Rm62 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.77927e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1365 2.3e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF03141//PF04851//PF00270 Putative S-adenosyl-L-methionine-dependent methyltransferase//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0005524//GO:0008168//GO:0003676//GO:0016787//GO:0003677 ATP binding//methyltransferase activity//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.37608 BF_2 512.37 71.23 588 478250527 ENN71022.1 259 3.5e-20 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 Q501J6 143 4.1e-08 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF03396 Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0019083//GO:0006206//GO:0006351//GO:0006144 viral transcription//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG0331 ATP-dependent RNA helicase Cluster-8309.37609 BF_2 218.10 1.96 4953 642916747 XP_972619.2 2242 3.4e-249 PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916749|ref|XP_008192467.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum]>gi|642916751|ref|XP_008192470.1| PREDICTED: mitogen-activated protein kinase kinase kinase 13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K04422 MAP3K13, LZK mitogen-activated protein kinase kinase kinase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K04422 Q12852 1037 7.5e-111 Mitogen-activated protein kinase kinase kinase 12 OS=Homo sapiens GN=MAP3K12 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG4721 Serine/threonine protein kinase, contains leucine zipper domain Cluster-8309.3761 BF_2 17.00 1.17 893 33096741 CAE11873.1 1196 1.2e-128 hypothetical protein [Homo sapiens] 16740988 BC016346.1 871 0 Homo sapiens ferritin, light polypeptide, mRNA (cDNA clone MGC:24392 IMAGE:4066010), complete cds K13625 FTL ferritin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K13625 P02792 842 5.5e-89 Ferritin light chain OS=Homo sapiens GN=FTL PE=1 SV=2 PF00210 Ferritin-like domain GO:0006879 cellular iron ion homeostasis GO:0008199 ferric iron binding -- -- -- -- Cluster-8309.37611 BF_2 264.02 3.80 3194 642910245 XP_008198545.1 580 1.2e-56 PREDICTED: protein pygopus isoform X2 [Tribolium castaneum] 241695262 XM_002412985.1 132 6.05468e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 427 2.6e-40 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF00075//PF13639//PF17123//PF00628//PF02121 RNase H//Ring finger domain//RING-like zinc finger//PHD-finger//Phosphatidylinositol transfer protein GO:0051252//GO:0006810 regulation of RNA metabolic process//transport GO:0004523//GO:0005515//GO:0008270//GO:0003676 RNA-DNA hybrid ribonuclease activity//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.37612 BF_2 129.39 1.87 3188 642910245 XP_008198545.1 635 4.8e-63 PREDICTED: protein pygopus isoform X2 [Tribolium castaneum] 241695262 XM_002412985.1 132 6.04318e-60 Ixodes scapularis pygopus, putative, mRNA -- -- -- -- Q9V9W8 437 1.8e-41 Protein pygopus OS=Drosophila melanogaster GN=pygo PE=1 SV=1 PF17123//PF00628//PF02121//PF00075//PF13639 RING-like zinc finger//PHD-finger//Phosphatidylinositol transfer protein//RNase H//Ring finger domain GO:0051252//GO:0006810 regulation of RNA metabolic process//transport GO:0004523//GO:0005515//GO:0008270//GO:0003676 RNA-DNA hybrid ribonuclease activity//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.37613 BF_2 38.01 0.34 4987 91085983 XP_972029.1 1866 1.4e-205 PREDICTED: TBC1 domain family member 31 [Tribolium castaneum]>gi|270010179|gb|EFA06627.1| hypothetical protein TcasGA2_TC009546 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DN5 1041 2.6e-111 TBC1 domain family member 31 OS=Homo sapiens GN=TBC1D31 PE=2 SV=2 PF03091//PF00156//PF03310//PF06689 CutA1 divalent ion tolerance protein//Phosphoribosyl transferase domain//Caulimovirus DNA-binding protein//ClpX C4-type zinc finger GO:0010038//GO:0009116 response to metal ion//nucleoside metabolic process GO:0003677//GO:0008270//GO:0046983 DNA binding//zinc ion binding//protein dimerization activity -- -- KOG1712 Adenine phosphoribosyl transferases Cluster-8309.37614 BF_2 5050.00 174.90 1495 197313765 NP_001127918.1 502 6.0e-48 uncharacterized protein LOC100187736 [Tribolium castaneum]>gi|270005547|gb|EFA01995.1| hypothetical protein TcasGA2_TC007616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37616 BF_2 253.16 1.56 7097 642931401 XP_008196564.1 7503 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 [Tribolium castaneum] 170051315 XM_001861674.1 59 5.15019e-19 Culex quinquefasciatus BIG3, mRNA K17572 ARFGEF3, KEPI brefeldin A-inhibited guanine nucleotide-exchange protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17572 Q3UGY8 1263 6.7e-137 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Mus musculus GN=Arfgef3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.37617 BF_2 929.00 28.37 1657 332374372 AEE62327.1 1218 6.3e-131 unknown [Dendroctonus ponderosae]>gi|478257069|gb|ENN77232.1| hypothetical protein YQE_06062, partial [Dendroctonus ponderosae] -- -- -- -- -- K09554 CDC37 cell division cycle protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K09554 Q24276 1052 4.6e-113 Hsp90 co-chaperone Cdc37 OS=Drosophila melanogaster GN=Cdc37 PE=1 SV=1 PF03234 Cdc37 N terminal kinase binding -- -- GO:0019901 protein kinase binding -- -- KOG2260 Cell division cycle 37 protein, CDC37 Cluster-8309.37618 BF_2 839.48 16.42 2426 91089929 XP_973045.1 413 2.0e-37 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04309//PF00436 Glycerol-3-phosphate responsive antiterminator//Single-strand binding protein family GO:0009607//GO:0006355 response to biotic stimulus//regulation of transcription, DNA-templated GO:0003697 single-stranded DNA binding -- -- -- -- Cluster-8309.37619 BF_2 1398.97 4.42 13521 642929047 XP_008195667.1 13180 0.0e+00 PREDICTED: baculoviral IAP repeat-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10586 BIRC6, BRUCE baculoviral IAP repeat-containing protein 6 (apollon) http://www.genome.jp/dbget-bin/www_bget?ko:K10586 O88738 3109 0.0e+00 Baculoviral IAP repeat-containing protein 6 OS=Mus musculus GN=Birc6 PE=1 SV=2 PF12356//PF00844 Protein of unknown function (DUF3643)//Geminivirus coat protein/nuclear export factor BR1 family GO:0016567//GO:0006915//GO:0032465 protein ubiquitination//apoptotic process//regulation of cytokinesis GO:0005198//GO:0004842 structural molecule activity//ubiquitin-protein transferase activity GO:0019028 viral capsid KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.37622 BF_2 41.13 0.35 5148 91086147 XP_969343.1 2917 0.0e+00 PREDICTED: integrator complex subunit 11 [Tribolium castaneum]>gi|270009886|gb|EFA06334.1| hypothetical protein TcasGA2_TC009205 [Tribolium castaneum] 826440986 XM_012674849.1 377 0 PREDICTED: Monomorium pharaonis integrator complex subunit 11 (LOC105833262), transcript variant X4, mRNA K13148 CPSF3L, INTS11 integrator complex subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13148 Q5ZIH0 2284 2.0e-255 Integrator complex subunit 11 OS=Gallus gallus GN=CPSF3L PE=2 SV=1 -- -- -- -- GO:0016787 hydrolase activity -- -- KOG1136 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.37623 BF_2 1658.00 47.58 1745 478263358 ENN81734.1 388 1.2e-34 hypothetical protein YQE_01873, partial [Dendroctonus ponderosae]>gi|546681306|gb|ERL91420.1| hypothetical protein D910_08752 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0030431//GO:1903818//GO:0032222 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.37625 BF_2 93.33 0.93 4495 642913077 XP_008201380.1 1635 7.5e-179 PREDICTED: disks large 1 tumor suppressor protein isoform X4 [Tribolium castaneum] 462373132 APGK01024854.1 117 1.86368e-51 Dendroctonus ponderosae Seq01024864, whole genome shotgun sequence K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 1160 3.7e-125 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00018//PF14604//PF00595 PDZ domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.37627 BF_2 4.42 0.32 869 642913083 XP_008201383.1 736 2.6e-75 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 642913082 XM_008203161.1 259 4.03392e-131 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X7, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 321 1.4e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.37628 BF_2 418.33 1.38 12995 270007354 EFA03802.1 5836 0.0e+00 hypothetical protein TcasGA2_TC013915 [Tribolium castaneum] 642917043 XM_008192874.1 352 0 PREDICTED: Tribolium castaneum diacylglycerol kinase eta-like (LOC103312380), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B4K6T8 2049 8.8e-228 Diacylglycerol kinase eta OS=Drosophila mojavensis GN=GI24133 PE=3 SV=1 PF02198//PF16866//PF07649//PF00749//PF07647//PF02017//PF00536//PF00130//PF00609//PF00781 Sterile alpha motif (SAM)/Pointed domain//PHD-finger//C1-like domain//tRNA synthetases class I (E and Q), catalytic domain//SAM domain (Sterile alpha motif)//CIDE-N domain//SAM domain (Sterile alpha motif)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//Diacylglycerol kinase catalytic domain GO:0007205//GO:0009395//GO:0043039//GO:0055114//GO:0035556//GO:0046486//GO:0006915 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//tRNA aminoacylation//oxidation-reduction process//intracellular signal transduction//glycerolipid metabolic process//apoptotic process GO:0005515//GO:0004143//GO:0005524//GO:0016876//GO:0047134//GO:0043565//GO:0016301 protein binding//diacylglycerol kinase activity//ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//protein-disulfide reductase activity//sequence-specific DNA binding//kinase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1170 Diacylglycerol kinase Cluster-8309.37629 BF_2 8477.98 563.09 917 91076492 XP_972907.1 875 2.1e-91 PREDICTED: 60S ribosomal protein L18a [Tribolium castaneum]>gi|270002411|gb|EEZ98858.1| hypothetical protein TcasGA2_TC004468 [Tribolium castaneum] 815769202 XM_012379287.1 145 1.0052e-67 PREDICTED: Linepithema humile 60S ribosomal protein L18a (LOC105679340), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q8WQI7 768 2.2e-80 60S ribosomal protein L18a OS=Spodoptera frugiperda GN=RpL18A PE=2 SV=1 PF01775//PF09004 Ribosomal L18ae/LX protein domain//Domain of unknown function (DUF1891) GO:0055114//GO:0042254//GO:0006412 oxidation-reduction process//ribosome biogenesis//translation GO:0008168//GO:0003735//GO:0016706 methyltransferase activity//structural constituent of ribosome//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.37630 BF_2 10610.27 71.49 6496 642914795 XP_008190356.1 6809 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 1776 2.0e-196 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF00975//PF00107 Thioesterase domain//Zinc-binding dehydrogenase GO:0055114//GO:0009058 oxidation-reduction process//biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.37632 BF_2 566.53 5.49 4603 642917716 XP_008191343.1 3538 0.0e+00 PREDICTED: ecotropic viral integration site 5 ortholog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VYY9 2243 1.0e-250 Ecotropic viral integration site 5 ortholog OS=Drosophila melanogaster GN=Evi5 PE=1 SV=3 PF13013 F-box-like domain -- -- GO:0005515 protein binding -- -- KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.37635 BF_2 869.60 15.10 2696 123227460 CAM27169.1 262 7.3e-20 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] -- -- -- -- -- K13943 CBT cabut http://www.genome.jp/dbget-bin/www_bget?ko:K13943 Q05481 238 1.8e-18 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37636 BF_2 29.26 0.46 2943 531445261 AGT57839.1 756 4.2e-77 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V6D6 448 8.9e-43 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.37637 BF_2 1435.66 18.32 3565 189238905 XP_967915.2 2699 2.5e-302 PREDICTED: influenza virus NS1A-binding protein-like [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 1007 1.6e-107 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.37639 BF_2 31952.44 351.95 4085 91082899 XP_972170.1 1166 1.7e-124 PREDICTED: protein spire [Tribolium castaneum]>gi|270008222|gb|EFA04670.1| spire [Tribolium castaneum] 770075505 NM_001305498.1 122 2.81188e-54 Plutella xylostella translationally-controlled tumor protein homolog (LOC105389397), mRNA >gnl|BL_ORD_ID|1274647 Plutella xylostella mRNA for translationally controlled tumor protein, complete cds -- -- -- -- Q75VN3 776 1.1e-80 Translationally-controlled tumor protein homolog OS=Bombyx mori GN=Tctp PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.37640 BF_2 11.41 0.67 1004 478249924 ENN70431.1 484 4.9e-46 hypothetical protein YQE_12935, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P48593 402 6.5e-38 Calcium-binding protein E63-1 OS=Drosophila melanogaster GN=Eip63F-1 PE=2 SV=2 PF13499//PF13833//PF10591//PF13405//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.37641 BF_2 152.76 0.61 10827 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.37643 BF_2 518.10 13.23 1925 189241537 XP_970292.2 1199 1.2e-128 PREDICTED: tropomodulin isoform X2 [Tribolium castaneum] 642936894 XM_008196180.1 371 0 PREDICTED: Tribolium castaneum tropomodulin (LOC658846), transcript variant X5, mRNA K10370 TMOD tropomodulin http://www.genome.jp/dbget-bin/www_bget?ko:K10370 O01479 477 2.5e-46 Tropomodulin OS=Caenorhabditis elegans GN=unc-94 PE=1 SV=2 PF03250 Tropomodulin GO:0051694 pointed-end actin filament capping GO:0005523 tropomyosin binding -- -- KOG3735 Tropomodulin and leiomodulin Cluster-8309.37646 BF_2 112.44 0.99 5034 270003038 EEZ99485.1 388 3.3e-34 hypothetical protein TcasGA2_TC000060 [Tribolium castaneum] -- -- -- -- -- K00791 miaA, TRIT1 tRNA dimethylallyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00791 Q80UN9 283 2.1e-23 tRNA dimethylallyltransferase, mitochondrial OS=Mus musculus GN=Trit1 PE=2 SV=2 PF00096//PF01715 Zinc finger, C2H2 type//IPP transferase GO:0008033 tRNA processing GO:0046872 metal ion binding -- -- KOG1384 tRNA delta(2)-isopentenylpyrophosphate transferase Cluster-8309.37647 BF_2 221.95 3.67 2814 642927608 XP_008195333.1 1642 7.3e-180 PREDICTED: ras-responsive element-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 215 8.8e-16 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF13912//PF11093//PF01428//PF13465//PF00096 C2H2-type zinc finger//Mitochondrial export protein Som1//AN1-like Zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0042720 mitochondrial inner membrane peptidase complex -- -- Cluster-8309.37648 BF_2 811.90 15.20 2521 478251374 ENN71840.1 1392 6.4e-151 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 77 1.78916e-29 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q6GNL7 860 1.3e-90 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus laevis GN=aldh1l1 PE=2 SV=1 PF04869//PF02911//PF00171 Uso1 / p115 like vesicle tethering protein, head region//Formyl transferase, C-terminal domain//Aldehyde dehydrogenase family GO:0008152//GO:0006886//GO:0048280//GO:0009058//GO:0055114 metabolic process//intracellular protein transport//vesicle fusion with Golgi apparatus//biosynthetic process//oxidation-reduction process GO:0016491//GO:0016742 oxidoreductase activity//hydroxymethyl-, formyl- and related transferase activity GO:0000139//GO:0005737 Golgi membrane//cytoplasm KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.37649 BF_2 10.74 0.32 1689 478249731 ENN70239.1 400 4.6e-36 hypothetical protein YQE_13023, partial [Dendroctonus ponderosae]>gi|546677413|gb|ERL88250.1| hypothetical protein D910_05638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Y639 146 5.3e-08 Neuroplastin OS=Homo sapiens GN=NPTN PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37650 BF_2 1767.73 33.88 2470 546678684 ERL89252.1 394 3.3e-35 hypothetical protein D910_06625 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37652 BF_2 861.54 5.16 7272 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 6.0e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF01480//PF03015//PF01370//PF00309//PF00076//PF00642//PF01073//PF01400//PF01429 PWI domain//Male sterility protein//NAD dependent epimerase/dehydratase family//Sigma-54 factor, Activator interacting domain (AID)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//3-beta hydroxysteroid dehydrogenase/isomerase family//Astacin (Peptidase family M12A)//Methyl-CpG binding domain GO:0006355//GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0006206//GO:0006508//GO:0006352//GO:0006351//GO:0008210//GO:0006397//GO:0006144 regulation of transcription, DNA-templated//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//pyrimidine nucleobase metabolic process//proteolysis//DNA-templated transcription, initiation//transcription, DNA-templated//estrogen metabolic process//mRNA processing//purine nucleobase metabolic process GO:0080019//GO:0003700//GO:0050662//GO:0003854//GO:0004222//GO:0003899//GO:0016616//GO:0016987//GO:0003676//GO:0046872//GO:0003824//GO:0003677 fatty-acyl-CoA reductase (alcohol-forming) activity//transcription factor activity, sequence-specific DNA binding//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//metalloendopeptidase activity//DNA-directed RNA polymerase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//sigma factor activity//nucleic acid binding//metal ion binding//catalytic activity//DNA binding GO:0005730//GO:0005634//GO:0005667 nucleolus//nucleus//transcription factor complex KOG1221 Acyl-CoA reductase Cluster-8309.37653 BF_2 651.36 5.66 5099 478263483 ENN81838.1 154 4.6e-07 hypothetical protein YQE_01777, partial [Dendroctonus ponderosae]>gi|546685487|gb|ERL94985.1| hypothetical protein D910_12257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37654 BF_2 410.63 9.39 2116 91091144 XP_970545.1 1198 1.7e-128 PREDICTED: uncharacterized protein LOC659120 [Tribolium castaneum]>gi|270014092|gb|EFA10540.1| hypothetical protein TcasGA2_TC012795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.37655 BF_2 80.53 0.60 5884 332375456 AEE62869.1 2168 1.5e-240 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 149 3.97593e-69 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 1819 1.9e-201 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF03328//PF00478//PF00224 HpcH/HpaI aldolase/citrate lyase family//IMP dehydrogenase / GMP reductase domain//Pyruvate kinase, barrel domain GO:0006144//GO:0006096//GO:0055114//GO:0006094//GO:0015976 purine nucleobase metabolic process//glycolytic process//oxidation-reduction process//gluconeogenesis//carbon utilization GO:0004743//GO:0030955//GO:0003824//GO:0000287 pyruvate kinase activity//potassium ion binding//catalytic activity//magnesium ion binding -- -- KOG2323 Pyruvate kinase Cluster-8309.37656 BF_2 1663.47 19.85 3792 270010125 EFA06573.1 1630 2.4e-178 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] 642927258 XM_969189.2 206 5.26055e-101 PREDICTED: Tribolium castaneum uncharacterized LOC663129 (LOC663129), mRNA K17776 MTX metaxin http://www.genome.jp/dbget-bin/www_bget?ko:K17776 Q2L969 681 1.1e-69 Metaxin-2 OS=Sus scrofa GN=MTX2 PE=2 SV=1 PF10568//PF13903 Outer mitochondrial membrane transport complex protein//PMP-22/EMP/MP20/Claudin tight junction GO:0006626 protein targeting to mitochondrion -- -- GO:0005741//GO:0016021 mitochondrial outer membrane//integral component of membrane KOG3027 Mitochondrial outer membrane protein Metaxin 2, Metaxin 1-binding protein Cluster-8309.37657 BF_2 183.53 1.45 5581 478250929 ENN71414.1 1135 8.9e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.27137e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF00852//PF04889//PF00956//PF03606 Glycosyltransferase family 10 (fucosyltransferase) C-term//Cwf15/Cwc15 cell cycle control protein//Nucleosome assembly protein (NAP)//C4-dicarboxylate anaerobic carrier GO:0006334//GO:0000398//GO:0006486 nucleosome assembly//mRNA splicing, via spliceosome//protein glycosylation GO:0008417 fucosyltransferase activity GO:0005681//GO:0016021//GO:0005634//GO:0016020 spliceosomal complex//integral component of membrane//nucleus//membrane KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.3766 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37661 BF_2 2061.29 63.79 1639 478258253 ENN78382.1 1145 1.8e-122 hypothetical protein YQE_05183, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 347 2.5e-31 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF07354//PF13895//PF04138 Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//GtrA-like protein GO:0006810//GO:0007339//GO:0000271 transport//binding of sperm to zona pellucida//polysaccharide biosynthetic process GO:0005515 protein binding GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.37662 BF_2 42.56 0.35 5357 642930595 XP_001807608.2 1374 1.6e-148 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00240//PF10410//PF03091 Ubiquitin family//DnaB-helicase binding domain of primase//CutA1 divalent ion tolerance protein GO:0010038 response to metal ion GO:0005515//GO:0016779 protein binding//nucleotidyltransferase activity -- -- -- -- Cluster-8309.37663 BF_2 81.39 0.72 5002 91084021 XP_975350.1 2492 3.5e-278 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 571571862 XM_006564848.1 555 0 PREDICTED: Apis mellifera uncharacterized LOC551823 (LOC551823), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q9BUQ8 2076 2.5e-231 Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens GN=DDX23 PE=1 SV=3 PF00176//PF04851//PF00270//PF06862 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524//GO:0008026 DNA binding//hydrolase activity//nucleic acid binding//ATP binding//ATP-dependent helicase activity GO:0005634 nucleus KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.37667 BF_2 159.06 5.54 1488 91082001 XP_969328.1 930 1.4e-97 PREDICTED: vacuolar protein sorting-associated protein 37A [Tribolium castaneum]>gi|270007313|gb|EFA03761.1| hypothetical protein TcasGA2_TC013872 [Tribolium castaneum] -- -- -- -- -- K12185 VPS37 ESCRT-I complex subunit VPS37 http://www.genome.jp/dbget-bin/www_bget?ko:K12185 Q8NEZ2 283 6.1e-24 Vacuolar protein sorting-associated protein 37A OS=Homo sapiens GN=VPS37A PE=1 SV=1 PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- KOG3270 Uncharacterized conserved protein Cluster-8309.37668 BF_2 58.90 0.95 2869 554879894 XP_005949741.1 566 4.4e-55 PREDICTED: zinc finger protein 585B-like [Haplochromis burtoni] 815905920 XM_012383378.1 159 5.31751e-75 PREDICTED: Bombus impatiens another transcription unit protein (LOC100742825), transcript variant X2, mRNA K15177 LEO1 RNA polymerase-associated protein LEO1 http://www.genome.jp/dbget-bin/www_bget?ko:K15177 O75437 524 1.3e-51 Zinc finger protein 254 OS=Homo sapiens GN=ZNF254 PE=2 SV=3 PF13465//PF07975//PF13912//PF01363//PF04004//PF02892//PF04810//PF16622//PF00346//PF05191//PF00096//PF00130//PF06397//PF16866 Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//FYVE zinc finger//Leo1-like protein//BED zinc finger//Sec23/Sec24 zinc finger//zinc-finger C2H2-type//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Desulfoferrodoxin, N-terminal domain//PHD-finger GO:0006886//GO:0006281//GO:0046034//GO:0016570//GO:0055114//GO:0035556//GO:0006888//GO:0006368//GO:0006144 intracellular protein transport//DNA repair//ATP metabolic process//histone modification//oxidation-reduction process//intracellular signal transduction//ER to Golgi vesicle-mediated transport//transcription elongation from RNA polymerase II promoter//purine nucleobase metabolic process GO:0008270//GO:0004017//GO:0005506//GO:0048038//GO:0003677//GO:0016651//GO:0005515//GO:0051287//GO:0046872 zinc ion binding//adenylate kinase activity//iron ion binding//quinone binding//DNA binding//oxidoreductase activity, acting on NAD(P)H//protein binding//NAD binding//metal ion binding GO:0016593//GO:0030127 Cdc73/Paf1 complex//COPII vesicle coat -- -- Cluster-8309.37669 BF_2 15.68 0.39 1979 264667437 ACY71304.1 658 6.5e-66 ribosomal protein S17 [Chrysomela tremula] 780657916 XM_011693770.1 153 7.90089e-72 PREDICTED: Wasmannia auropunctata 40S ribosomal protein S17 (LOC105452559), mRNA K02962 RP-S17e, RPS17 small subunit ribosomal protein S17e http://www.genome.jp/dbget-bin/www_bget?ko:K02962 Q962R2 595 5.4e-60 40S ribosomal protein S17 OS=Spodoptera frugiperda GN=RpS17 PE=2 SV=3 PF02175//PF00833 Serpentine type 7TM GPCR chemoreceptor Srb//Ribosomal S17 GO:0007606//GO:0042254//GO:0007165//GO:0006412 sensory perception of chemical stimulus//ribosome biogenesis//signal transduction//translation GO:0003735//GO:0004888 structural constituent of ribosome//transmembrane signaling receptor activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG0187 40S ribosomal protein S17 Cluster-8309.37670 BF_2 13081.31 42.68 13108 642920090 XP_008192200.1 2117 2.8e-234 PREDICTED: histone acetyltransferase Tip60 [Tribolium castaneum]>gi|270006006|gb|EFA02454.1| hypothetical protein TcasGA2_TC008142 [Tribolium castaneum] 642920091 XM_970322.3 333 4.60858e-171 PREDICTED: Tribolium castaneum 40S ribosomal protein S2 (LOC664315), mRNA K11304 TIP60, KAT5, ESA1 histone acetyltransferase HTATIP http://www.genome.jp/dbget-bin/www_bget?ko:K11304 Q5RBG4 1506 8.2e-165 Histone acetyltransferase KAT5 OS=Pongo abelii GN=KAT5 PE=2 SV=1 PF03719//PF13855//PF00560//PF01853//PF05261//PF00583//PF13508//PF00333 Ribosomal protein S5, C-terminal domain//Leucine rich repeat//Leucine Rich Repeat//MOZ/SAS family//TraM protein, DNA-binding//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Ribosomal protein S5, N-terminal domain GO:0006355//GO:0042254//GO:0000746//GO:0042967//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//conjugation//acyl-carrier-protein biosynthetic process//translation GO:0003735//GO:0016747//GO:0003723//GO:0003677//GO:0008080//GO:0005515 structural constituent of ribosome//transferase activity, transferring acyl groups other than amino-acyl groups//RNA binding//DNA binding//N-acetyltransferase activity//protein binding GO:0005840//GO:0005634 ribosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.37671 BF_2 147.24 7.11 1154 642929992 XP_975639.2 444 2.5e-41 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6V5K9 261 1.7e-21 Zinc finger protein 474 OS=Mus musculus GN=Znf474 PE=2 SV=2 PF05191//PF00096 Adenylate kinase, active site lid//Zinc finger, C2H2 type GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017//GO:0046872 adenylate kinase activity//metal ion binding -- -- -- -- Cluster-8309.37673 BF_2 421.88 2.85 6470 820805566 AKG92774.1 1694 1.6e-185 clockwork orange [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q5R4R3 566 4.0e-56 Prolyl 3-hydroxylase OGFOD1 OS=Pongo abelii GN=OGFOD1 PE=2 SV=1 PF10637//PF13640//PF00010//PF07527 Oxoglutarate and iron-dependent oxygenase degradation C-term//2OG-Fe(II) oxygenase superfamily//Helix-loop-helix DNA-binding domain//Hairy Orange GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0031418//GO:0016706//GO:0005506//GO:0003677//GO:0016491//GO:0046983 L-ascorbic acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron ion binding//DNA binding//oxidoreductase activity//protein dimerization activity -- -- -- -- Cluster-8309.37674 BF_2 1400.26 10.28 5984 642919151 XP_008191758.1 2968 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 821465109 XM_003759914.2 38 2.04815e-07 PREDICTED: Sarcophilus harrisii complement component 6 (C6), mRNA -- -- -- -- O88307 1793 2.0e-198 Sortilin-related receptor OS=Mus musculus GN=Sorl1 PE=1 SV=3 PF00057//PF04345//PF00041//PF11057 Low-density lipoprotein receptor domain class A//Chorismate lyase//Fibronectin type III domain//Cortexin of kidney GO:0006744 ubiquinone biosynthetic process GO:0005515//GO:0008813 protein binding//chorismate lyase activity GO:0005737//GO:0031224 cytoplasm//intrinsic component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.37675 BF_2 594.94 16.40 1805 332376226 AEE63253.1 1767 1.5e-194 unknown [Dendroctonus ponderosae] 282158080 NM_001170613.1 385 0 Tribolium castaneum arrestin 2 (Arr2), mRNA K13805 ARR2 arrestin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13805 P32122 1583 1.3e-174 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.37676 BF_2 8.53 2.03 463 478251559 ENN72021.1 612 3.2e-61 hypothetical protein YQE_11312, partial [Dendroctonus ponderosae]>gi|546681223|gb|ERL91358.1| hypothetical protein D910_08690, partial [Dendroctonus ponderosae] 282158080 NM_001170613.1 157 1.04504e-74 Tribolium castaneum arrestin 2 (Arr2), mRNA K13805 ARR2 arrestin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13805 P32122 541 2.3e-54 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.37677 BF_2 2479.06 3.87 27098 642915997 XP_008190849.1 3577 0.0e+00 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02224 247 1.7e-18 Centromere-associated protein E OS=Homo sapiens GN=CENPE PE=1 SV=2 PF02629//PF02444//PF05280 CoA binding domain//Hepatitis E virus ORF-2 (Putative capsid protein)//Flagellar transcriptional activator (FlhC) GO:1902208//GO:0045893 regulation of bacterial-type flagellum assembly//positive regulation of transcription, DNA-templated GO:0048037//GO:0003677 cofactor binding//DNA binding GO:0030430 host cell cytoplasm -- -- Cluster-8309.37679 BF_2 804.90 5.53 6377 642918631 XP_008200395.1 1308 8.8e-141 PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X3 [Tribolium castaneum] 642918632 XM_008202178.1 261 2.36552e-131 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 6 regulatory subunit 3 (LOC655675), transcript variant X5, mRNA K15501 PPP6R3, SAPS3 serine/threonine-protein phosphatase 6 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15501 O75170 775 2.3e-80 Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens GN=PPP6R2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2073 SAP family cell cycle dependent phosphatase-associated protein Cluster-8309.37680 BF_2 1321.92 10.57 5519 478250929 ENN71414.1 1135 8.8e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.21243e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF00852//PF03606//PF00956//PF04889 Glycosyltransferase family 10 (fucosyltransferase) C-term//C4-dicarboxylate anaerobic carrier//Nucleosome assembly protein (NAP)//Cwf15/Cwc15 cell cycle control protein GO:0006334//GO:0000398//GO:0006486 nucleosome assembly//mRNA splicing, via spliceosome//protein glycosylation GO:0008417 fucosyltransferase activity GO:0005681//GO:0016021//GO:0005634//GO:0016020 spliceosomal complex//integral component of membrane//nucleus//membrane KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.37681 BF_2 1589.74 12.70 5523 478250929 ENN71414.1 1135 8.8e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.21623e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF03606//PF04889//PF00956//PF00852 C4-dicarboxylate anaerobic carrier//Cwf15/Cwc15 cell cycle control protein//Nucleosome assembly protein (NAP)//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486//GO:0000398//GO:0006334 protein glycosylation//mRNA splicing, via spliceosome//nucleosome assembly GO:0008417 fucosyltransferase activity GO:0016020//GO:0016021//GO:0005634//GO:0005681 membrane//integral component of membrane//nucleus//spliceosomal complex KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.37683 BF_2 635.21 8.82 3300 478256479 ENN76664.1 1700 1.6e-186 hypothetical protein YQE_06843, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q869E1 144 1.8e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37688 BF_2 6806.00 96.26 3245 91081299 XP_968887.1 2316 5.9e-258 PREDICTED: cleft lip and palate transmembrane protein 1 homolog [Tribolium castaneum]>gi|270006092|gb|EFA02540.1| hypothetical protein TcasGA2_TC008245 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96005 1624 4.2e-179 Cleft lip and palate transmembrane protein 1 OS=Homo sapiens GN=CLPTM1 PE=1 SV=1 PF02740//PF00225//PF13409//PF01529//PF02798//PF13417//PF05602 Colipase, C-terminal domain//Kinesin motor domain//Glutathione S-transferase, N-terminal domain//DHHC palmitoyltransferase//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Cleft lip and palate transmembrane protein 1 (CLPTM1) GO:0007586//GO:0007018//GO:0016042//GO:0007017 digestion//microtubule-based movement//lipid catabolic process//microtubule-based process GO:0003777//GO:0005515//GO:0005524//GO:0008017//GO:0008047//GO:0008270 microtubule motor activity//protein binding//ATP binding//microtubule binding//enzyme activator activity//zinc ion binding GO:0045298//GO:0005874//GO:0016021//GO:0005576 tubulin complex//microtubule//integral component of membrane//extracellular region KOG2489 Transmembrane protein Cluster-8309.37689 BF_2 1728.67 17.68 4378 642933803 XP_008197345.1 467 2.0e-43 PREDICTED: COMM domain-containing protein 8-like [Tribolium castaneum]>gi|270013592|gb|EFA10040.1| hypothetical protein TcasGA2_TC012212 [Tribolium castaneum] 642935946 XM_008200020.1 141 8.26602e-65 PREDICTED: Tribolium castaneum pollen-specific leucine-rich repeat extensin-like protein 1 (LOC658987), transcript variant X2, mRNA -- -- -- -- Q9CZG3 131 7.5e-06 COMM domain-containing protein 8 OS=Mus musculus GN=Commd8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37694 BF_2 425.52 1.64 11157 270008334 EFA04782.1 2089 4.2e-231 hypothetical protein TcasGA2_TC030779 [Tribolium castaneum] -- -- -- -- -- K10630 RBCK1, HOIL1 RanBP-type and C3HC4-type zinc finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10630 E6ZIJ1 896 3.8e-94 RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Dicentrarchus labrax GN=rbck1 PE=3 SV=1 PF00240//PF00097//PF00641//PF14634//PF13639//PF09174 Ubiquitin family//Zinc finger, C3HC4 type (RING finger)//Zn-finger in Ran binding protein and others//zinc-RING finger domain//Ring finger domain//Maf1 regulator GO:0016480 negative regulation of transcription from RNA polymerase III promoter GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.37696 BF_2 2861.91 58.04 2350 91079768 XP_966889.1 876 4.0e-91 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 407 4.0e-38 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF00899//PF01370//PF00106//PF01073 ThiF family//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0008152//GO:0008209//GO:0055114//GO:0006694//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0050662//GO:0003824//GO:0003854//GO:0008641//GO:0000166 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//small protein activating enzyme activity//nucleotide binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.37698 BF_2 2207.04 32.58 3121 478255961 ENN76162.1 952 8.3e-100 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] 264667412 GU120442.1 190 3.38775e-92 Chrysomela tremulae ribosomal protein L27 (RpL27) mRNA, complete cds K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 O08812 633 3.3e-64 Cationic amino acid transporter 3 OS=Rattus norvegicus GN=Slc7a3 PE=2 SV=1 PF00324//PF13520//PF01777 Amino acid permease//Amino acid permease//Ribosomal L27e protein family GO:0042254//GO:0003333//GO:0006810//GO:0006412//GO:0006865//GO:0055085 ribosome biogenesis//amino acid transmembrane transport//transport//translation//amino acid transport//transmembrane transport GO:0003735//GO:0015171 structural constituent of ribosome//amino acid transmembrane transporter activity GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular -- -- Cluster-8309.37699 BF_2 27.40 0.34 3700 642924614 XP_008194364.1 2666 1.7e-298 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.1e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.37701 BF_2 522.82 5.27 4439 478260090 ENN79875.1 2563 1.8e-286 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 7.00419e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 2116 5.1e-236 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006013//GO:0006000//GO:0006094//GO:0006096//GO:0006098//GO:0006012 mannose metabolic process//fructose metabolic process//gluconeogenesis//glycolytic process//pentose-phosphate shunt//galactose metabolic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.37704 BF_2 736.91 11.42 2987 91092022 XP_970951.1 1065 6.2e-113 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 818 1.1e-85 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF03051//PF00112//PF05151 Peptidase C1-like family//Papain family cysteine protease//Photosystem II reaction centre M protein (PsbM) GO:0006508//GO:0015979//GO:0019684 proteolysis//photosynthesis//photosynthesis, light reaction GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity GO:0016021//GO:0009523 integral component of membrane//photosystem II KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.37705 BF_2 78.79 1.48 2513 478250805 ENN71297.1 632 8.5e-63 hypothetical protein YQE_12222, partial [Dendroctonus ponderosae] 768431929 XM_011558966.1 105 4.85438e-45 PREDICTED: Plutella xylostella troponin C (LOC105388115), mRNA -- -- -- -- P47947 370 8.4e-34 Troponin C, isoform 1 OS=Drosophila melanogaster GN=TpnC41C PE=2 SV=2 PF13202//PF12763//PF00036//PF13833//PF13405//PF13499 EF hand//Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.37706 BF_2 1469.47 10.62 6078 642917793 XP_008191289.1 2136 8.2e-237 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 isoform X3 [Tribolium castaneum] 768412757 XM_011570168.1 425 0 PREDICTED: Plutella xylostella glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1-like (LOC105398114), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q4KMC4 1723 2.6e-190 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Rattus norvegicus GN=Gfpt2 PE=2 SV=3 PF11593//PF01380//PF13580 Mediator complex subunit 3 fungal//SIS domain//SIS domain GO:0006357//GO:0005975 regulation of transcription from RNA polymerase II promoter//carbohydrate metabolic process GO:0030246//GO:0001104 carbohydrate binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.37707 BF_2 359.96 3.09 5160 478256311 ENN76501.1 492 3.0e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37708 BF_2 749.40 5.56 5928 827549501 XP_012546855.1 643 1.1e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.3771 BF_2 36.83 2.85 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37710 BF_2 5339.00 74.35 3291 642917978 XP_008198968.1 593 3.7e-58 PREDICTED: mediator of RNA polymerase II transcription subunit 29 [Tribolium castaneum]>gi|270004684|gb|EFA01132.1| hypothetical protein TcasGA2_TC010345 [Tribolium castaneum] -- -- -- -- -- K15142 MED29 mediator of RNA polymerase II transcription subunit 29 http://www.genome.jp/dbget-bin/www_bget?ko:K15142 Q5ISW3 407 5.6e-38 Mediator of RNA polymerase II transcription subunit 29 OS=Bombyx mori GN=ix PE=2 SV=1 PF11568//PF04179//PF10152//PF10280//PF06624 Mediator complex subunit 29//Initiator tRNA phosphoribosyl transferase//Predicted coiled-coil domain-containing protein (DUF2360)//Mediator complex protein//Ribosome associated membrane protein RAMP4 GO:0006357//GO:0019988 regulation of transcription from RNA polymerase II promoter//charged-tRNA amino acid modification GO:0043399//GO:0001104 tRNA A64-2'-O-ribosylphosphate transferase activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005783//GO:0071203 mediator complex//endoplasmic reticulum//WASH complex KOG3491 Predicted membrane protein Cluster-8309.37711 BF_2 3679.09 15.59 10156 642920909 XP_008192611.1 9151 0.0e+00 PREDICTED: spectrin beta chain isoform X5 [Tribolium castaneum] 642920908 XM_008194389.1 1972 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7742 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00307//PF00435 Calponin homology (CH) domain//Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.37713 BF_2 446.03 7.71 2707 748995286 AJE75665.1 1586 2.2e-173 putative glycosyl hydrolase [Chrysomela lapponica] 634006820 KF377836.1 35 4.27913e-06 Phyllotreta striolata glycoside hydrolase family 1 (GH1-8) mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1222 1.4e-132 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232//PF00150 Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.37714 BF_2 1028.84 59.38 1012 642916834 XP_008199522.1 1552 7.1e-170 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum]>gi|642916836|ref|XP_008199523.1| PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X1 [Tribolium castaneum] 642916839 XM_008201303.1 715 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2B catalytic subunit 2-like (LOC657135), transcript variant X4, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 1378 4.4e-151 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.37715 BF_2 27.76 0.60 2219 270007560 EFA04008.1 507 2.3e-48 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 3.4e-23 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322//PF08612 Endothelin family//TATA-binding related factor (TRF) of subunit 20 of Mediator complex GO:0006357//GO:0019229 regulation of transcription from RNA polymerase II promoter//regulation of vasoconstriction GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005576 mediator complex//extracellular region -- -- Cluster-8309.37716 BF_2 6587.58 96.19 3152 642939230 XP_008194770.1 1711 8.1e-188 PREDICTED: uncharacterized protein LOC656988 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37719 BF_2 959.12 10.11 4256 91079020 XP_974879.1 2330 1.8e-259 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q5REU4 1468 6.8e-161 Staphylococcal nuclease domain-containing protein 1 OS=Pongo abelii GN=SND1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.37720 BF_2 1677.31 16.39 4569 642935032 XP_008199913.1 2835 0.0e+00 PREDICTED: protein Skeletor, isoforms B/C isoform X2 [Tribolium castaneum]>gi|557470276|gb|AHA05988.1| truncated knickkopf 3 [Tribolium castaneum] 642935031 XM_008201691.1 245 1.32651e-122 PREDICTED: Tribolium castaneum knickkopf 3 (LOC657143), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 2286 1.0e-255 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.37721 BF_2 412.85 8.64 2286 189234241 XP_976116.2 673 1.4e-67 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 645003520 XM_008214369.1 86 1.60861e-34 PREDICTED: Nasonia vitripennis high affinity copper uptake protein 1 (LOC100122867), transcript variant X2, mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 362 6.4e-33 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane KOG3386 Copper transporter Cluster-8309.37722 BF_2 2131.75 17.30 5443 546683575 ERL93373.1 1149 2.1e-122 hypothetical protein D910_10665 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37723 BF_2 100.51 1.02 4407 91089973 XP_973833.1 4993 0.0e+00 PREDICTED: exportin-1 [Tribolium castaneum]>gi|270013547|gb|EFA09995.1| hypothetical protein TcasGA2_TC012162 [Tribolium castaneum] 462343018 APGK01035523.1 865 0 Dendroctonus ponderosae Seq01035533, whole genome shotgun sequence K14290 XPO1, CRM1 exportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14290 Q80U96 4220 0.0e+00 Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008536//GO:0008565 Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.37724 BF_2 62.31 0.46 5896 642937187 XP_008198730.1 1103 4.8e-117 PREDICTED: cuticular protein analogous to peritrophins 1-J isoform X2 [Tribolium castaneum] 642937188 XM_008200510.1 61 3.30567e-20 PREDICTED: Tribolium castaneum cuticular protein analogous to peritrophins 1-J (Cpap1-j), transcript variant X2, mRNA -- -- -- -- Q685J3 144 3.2e-07 Mucin-17 OS=Homo sapiens GN=MUC17 PE=1 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.37728 BF_2 2205.60 14.50 6649 642928597 XP_008199971.1 5998 0.0e+00 PREDICTED: autophagy-related protein 2 homolog A isoform X3 [Tribolium castaneum] -- -- -- -- -- K17906 ATG2 autophagy-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17906 Q80XK6 2306 7.1e-258 Autophagy-related protein 2 homolog B OS=Mus musculus GN=Atg2b PE=1 SV=3 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG2993 Cytoplasm to vacuole targeting protein Cluster-8309.37729 BF_2 316.17 11.17 1471 91076836 XP_974707.1 1517 1.2e-165 PREDICTED: 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial [Tribolium castaneum]>gi|270001821|gb|EEZ98268.1| hypothetical protein TcasGA2_TC000711 [Tribolium castaneum] 462377192 APGK01023399.1 60 2.9144e-20 Dendroctonus ponderosae Seq01023409, whole genome shotgun sequence K00167 BCKDHB, bkdA2 2-oxoisovalerate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00167 P35738 1276 4.3e-139 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial OS=Rattus norvegicus GN=Bckdhb PE=1 SV=3 PF00199//PF02780 Catalase//Transketolase, C-terminal domain GO:0006979//GO:0006804//GO:0008152//GO:0015947//GO:0055114//GO:0006568 response to oxidative stress//obsolete peroxidase reaction//metabolic process//methane metabolic process//oxidation-reduction process//tryptophan metabolic process GO:0003824//GO:0004096//GO:0020037 catalytic activity//catalase activity//heme binding -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.37730 BF_2 48.30 1.66 1505 478257936 ENN78074.1 1572 5.1e-172 hypothetical protein YQE_05228, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7Z2K6 886 7.4e-94 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.37731 BF_2 589.21 24.36 1299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37732 BF_2 319.71 6.31 2406 546675819 ERL86931.1 1426 6.9e-155 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 1044 5.6e-112 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 PF08273//PF01968//PF06723 Zinc-binding domain of primase-helicase//Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0006351//GO:0006269//GO:0000902 transcription, DNA-templated//DNA replication, synthesis of RNA primer//cell morphogenesis GO:0003896//GO:0016787//GO:0004386//GO:0008270 DNA primase activity//hydrolase activity//helicase activity//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.37733 BF_2 2722.56 26.04 4661 642926564 XP_008194922.1 3655 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: TBC1 domain family member 1 [Tribolium castaneum] -- -- -- -- -- K17902 TBC1D4, AS160 TBC1 domain family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17902 Q60949 1137 1.8e-122 TBC1 domain family member 1 OS=Mus musculus GN=Tbc1d1 PE=1 SV=3 PF00628//PF00640//PF13851//PF08416 PHD-finger//Phosphotyrosine interaction domain (PTB/PID)//Growth-arrest specific micro-tubule binding//Phosphotyrosine-binding domain GO:0048870 cell motility GO:0005515 protein binding GO:0031514 motile cilium KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.37734 BF_2 1383.57 8.80 6866 642926564 XP_008194922.1 3655 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: TBC1 domain family member 1 [Tribolium castaneum] -- -- -- -- -- K17902 TBC1D4, AS160 TBC1 domain family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17902 Q60949 1137 2.6e-122 TBC1 domain family member 1 OS=Mus musculus GN=Tbc1d1 PE=1 SV=3 PF13851//PF00640//PF08416//PF01022//PF04138//PF00628 Growth-arrest specific micro-tubule binding//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Bacterial regulatory protein, arsR family//GtrA-like protein//PHD-finger GO:0006355//GO:0000271//GO:0048870//GO:0006810 regulation of transcription, DNA-templated//polysaccharide biosynthetic process//cell motility//transport GO:0003700//GO:0005515 transcription factor activity, sequence-specific DNA binding//protein binding GO:0031514//GO:0016021//GO:0005667 motile cilium//integral component of membrane//transcription factor complex KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.37738 BF_2 35.26 1.06 1673 659495114 AID66668.1 1065 3.5e-113 short-chain specific acyl-CoA dehydrogenase [Agrotis segetum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q5RAS0 886 8.2e-94 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Pongo abelii GN=ACADS PE=2 SV=1 PF02771//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016627//GO:0050660 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.37739 BF_2 560.37 2.41 10034 91079160 XP_967064.1 4824 0.0e+00 PREDICTED: E3 SUMO-protein ligase RanBP2 [Tribolium castaneum]>gi|270003619|gb|EFA00067.1| hypothetical protein TcasGA2_TC002881 [Tribolium castaneum] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 371 2.6e-33 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF00641//PF00638//PF06810//PF04513 Zn-finger in Ran binding protein and others//RanBP1 domain//Phage minor structural protein GP20//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0046907 intracellular transport GO:0008270//GO:0005198 zinc ion binding//structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.37740 BF_2 133.96 0.89 6605 478255041 ENN75273.1 1173 4.1e-125 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 658861642 XM_008415365.1 133 3.50009e-60 PREDICTED: Poecilia reticulata phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 1058 3.7e-113 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF00520//PF15461//PF01409 Ion transport protein//Beta-carotene 15,15'-dioxygenase//tRNA synthetases class II core domain (F) GO:0055085//GO:0006811//GO:0055114//GO:0043039//GO:0006418 transmembrane transport//ion transport//oxidation-reduction process//tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0016702//GO:0005524//GO:0004812//GO:0005216 tRNA binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//ATP binding//aminoacyl-tRNA ligase activity//ion channel activity GO:0005737//GO:0016020 cytoplasm//membrane KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.37741 BF_2 10437.62 65.03 7001 332376114 AEE63197.1 1491 5.8e-162 unknown [Dendroctonus ponderosae] 332376113 BT128237.1 195 1.27026e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 954 4.5e-101 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF00412//PF13180//PF08782//PF05493 PDZ domain (Also known as DHR or GLGF)//LIM domain//PDZ domain//c-SKI Smad4 binding domain//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078//GO:0008270//GO:0005515//GO:0046332 hydrogen ion transmembrane transporter activity//zinc ion binding//protein binding//SMAD binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.37743 BF_2 8310.66 1283.30 558 91076454 XP_971838.1 459 2.2e-43 PREDICTED: ubiquitin-like protein FUBI [Tribolium castaneum]>gi|270002576|gb|EEZ99023.1| hypothetical protein TcasGA2_TC004892 [Tribolium castaneum] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 P0C2F0 185 5.2e-13 40S ribosomal protein S30 OS=Pongo abelii GN=FAU PE=3 SV=1 PF00240//PF04758 Ubiquitin family//Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-8309.37746 BF_2 10.00 3.18 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37747 BF_2 12515.28 68.20 7964 546672885 ERL84608.1 3419 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] 815792597 XM_012361475.1 47 2.70951e-12 PREDICTED: Linepithema humile fatty acid synthase-like (LOC105668856), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1962 6.6e-218 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00106//PF00975//PF00107//PF05524 short chain dehydrogenase//Thioesterase domain//Zinc-binding dehydrogenase//PEP-utilising enzyme, N-terminal GO:0008152//GO:0009401//GO:0055114//GO:0009058 metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//oxidation-reduction process//biosynthetic process GO:0016788//GO:0016491 hydrolase activity, acting on ester bonds//oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.37748 BF_2 752.19 51.18 902 642928915 XP_008195614.1 189 7.1e-12 PREDICTED: FK506-binding protein 5 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37750 BF_2 48.11 0.45 4733 270002885 EEZ99332.1 703 9.3e-71 serine protease P46 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75096 311 1.1e-26 Low-density lipoprotein receptor-related protein 4 OS=Homo sapiens GN=LRP4 PE=1 SV=4 PF03875//PF00057//PF07415//PF00089 Statherin//Low-density lipoprotein receptor domain class A//Gammaherpesvirus latent membrane protein (LMP2) protein//Trypsin GO:0042742//GO:0030500//GO:0019042//GO:0006508 defense response to bacterium//regulation of bone mineralization//viral latency//proteolysis GO:0005515//GO:0046848//GO:0004252 protein binding//hydroxyapatite binding//serine-type endopeptidase activity GO:0033644//GO:0005576 host cell membrane//extracellular region KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.37751 BF_2 259.68 5.30 2338 91091932 XP_966409.1 3387 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 808130532 XM_012312605.1 158 1.55521e-74 PREDICTED: Bombus terrestris structural maintenance of chromosomes protein 3 (LOC100648683), transcript variant X3, mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 Q5R4K5 1981 1.2e-220 Structural maintenance of chromosomes protein 3 OS=Pongo abelii GN=SMC3 PE=2 SV=1 PF04111//PF13304//PF06470//PF00005//PF01580 Autophagy protein Apg6//AAA domain, putative AbiEii toxin, Type IV TA system//SMC proteins Flexible Hinge Domain//ABC transporter//FtsK/SpoIIIE family GO:0006914//GO:0006281//GO:0051276//GO:0030261//GO:0006310//GO:0007062 autophagy//DNA repair//chromosome organization//chromosome condensation//DNA recombination//sister chromatid cohesion GO:0005515//GO:0005524//GO:0003677//GO:0000166//GO:0016887 protein binding//ATP binding//DNA binding//nucleotide binding//ATPase activity GO:0005634//GO:0005694 nucleus//chromosome KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.37758 BF_2 237.65 2.54 4194 478254062 ENN74354.1 272 7.9e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37761 BF_2 47136.00 1376.16 1720 332375446 AEE62864.1 1672 1.5e-183 unknown [Dendroctonus ponderosae] 332375445 BT127902.1 381 0 Dendroctonus ponderosae clone DPO115_B09 unknown mRNA K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P07764 1384 1.5e-151 Fructose-bisphosphate aldolase OS=Drosophila melanogaster GN=Ald PE=1 SV=5 PF00274 Fructose-bisphosphate aldolase class-I GO:0006000//GO:0006013//GO:0015976//GO:0006094//GO:0006020//GO:0006098//GO:0006096 fructose metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis//inositol metabolic process//pentose-phosphate shunt//glycolytic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.37762 BF_2 423.06 12.95 1654 642938321 XP_008192847.1 1878 1.8e-207 PREDICTED: argininosuccinate lyase [Tribolium castaneum] -- -- -- -- -- K01755 argH, ASL argininosuccinate lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01755 P51464 1470 1.5e-161 Argininosuccinate lyase OS=Lithobates catesbeiana GN=ASL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1316 Argininosuccinate lyase Cluster-8309.37763 BF_2 4072.43 178.79 1240 478250378 ENN70873.1 1152 2.1e-123 hypothetical protein YQE_12278, partial [Dendroctonus ponderosae]>gi|546672870|gb|ERL84593.1| hypothetical protein D910_02021 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 545 2.1e-54 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.37764 BF_2 5560.58 196.66 1470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.37765 BF_2 55.01 1.53 1792 332374576 AEE62429.1 1105 8.6e-118 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 272 5.03519e-138 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 987 1.7e-105 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.37766 BF_2 10421.70 214.88 2316 332374576 AEE62429.1 1472 3.1e-160 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 295 1.07088e-150 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1258 8.3e-137 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- -- -- Cluster-8309.37767 BF_2 2203.79 25.42 3914 91089461 XP_968383.1 1941 2.2e-214 PREDICTED: fatty-acid amide hydrolase 2 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6GMR7 1103 1.3e-118 Fatty-acid amide hydrolase 2 OS=Homo sapiens GN=FAAH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.37771 BF_2 9825.28 65.61 6552 642918534 XP_008191512.1 5436 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 2920 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF16656//PF13895//PF00041//PF16794//PF14604//PF00018 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain//Fibronectin-III type domain//Variant SH3 domain//SH3 domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.37772 BF_2 788.93 17.92 2129 817089825 XP_012267798.1 326 2.2e-27 PREDICTED: V-type proton ATPase 16 kDa proteolipid subunit [Athalia rosae] 594071842 XM_006059709.1 78 4.19012e-30 PREDICTED: Bubalus bubalis ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c (ATP6V0C), mRNA K02155 ATPeV0C, ATP6L V-type H+-transporting ATPase 16kDa proteolipid subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02155 O16110 319 5.8e-28 V-type proton ATPase 16 kDa proteolipid subunit OS=Aedes aegypti GN=AAEL000291 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0232 Vacuolar H+-ATPase V0 sector, subunits c/c' Cluster-8309.37773 BF_2 1562.35 58.10 1412 189238112 XP_001814047.1 1410 2.9e-153 PREDICTED: bleomycin hydrolase [Tribolium castaneum]>gi|270008738|gb|EFA05186.1| hypothetical protein TcasGA2_TC015316 [Tribolium castaneum] 158302192 XM_321804.4 224 1.90209e-111 Anopheles gambiae str. PEST AGAP001341-PA (AgaP_AGAP001341) mRNA, complete cds K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 P70645 1059 6.0e-114 Bleomycin hydrolase OS=Rattus norvegicus GN=Blmh PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG4128 Bleomycin hydrolases and aminopeptidases of cysteine protease family Cluster-8309.37774 BF_2 10922.00 379.22 1492 389608293 BAM17758.1 809 1.5e-83 elongation factor 1 gamma [Papilio xuthus] 157128963 XM_001661520.1 204 2.64056e-100 Aedes aegypti AAEL011288-RA mRNA K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 Q9NJH0 760 3.0e-79 Elongation factor 1-gamma OS=Drosophila melanogaster GN=Ef1gamma PE=2 SV=2 PF00739//PF12519//PF00647//PF01239//PF10596 Trans-activation protein X//Mitochondrial distribution and morphology protein 10//Elongation factor 1 gamma, conserved domain//Protein prenyltransferase alpha subunit repeat//U6-snRNA interacting domain of PrP8 GO:0006414//GO:0019079//GO:0018342//GO:0006448//GO:0007005 translational elongation//viral genome replication//protein prenylation//regulation of translational elongation//mitochondrion organization GO:0017070//GO:0008318//GO:0003746 U6 snRNA binding//protein prenyltransferase activity//translation elongation factor activity GO:0032865//GO:0005840 ERMES complex//ribosome KOG1627 Translation elongation factor EF-1 gamma Cluster-8309.37775 BF_2 4063.20 67.88 2791 332373526 AEE61904.1 1352 3.1e-146 unknown [Dendroctonus ponderosae]>gi|478254046|gb|ENN74338.1| hypothetical protein YQE_09308, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBX0 704 1.7e-72 Saccharopine dehydrogenase-like oxidoreductase OS=Homo sapiens GN=SCCPDH PE=1 SV=1 PF03435//PF01370//PF00106 Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- KOG2733 Uncharacterized membrane protein Cluster-8309.37777 BF_2 4483.65 51.92 3900 91089945 XP_973312.1 3473 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit A [Tribolium castaneum]>gi|270013675|gb|EFA10123.1| hypothetical protein TcasGA2_TC012303 [Tribolium castaneum] -- -- -- -- -- K03254 EIF3A translation initiation factor 3 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03254 Q173M7 2783 0.0e+00 Eukaryotic translation initiation factor 3 subunit A OS=Aedes aegypti GN=eIF3-S10 PE=3 SV=1 PF01399//PF02983 PCI domain//Alpha-lytic protease prodomain GO:0006413//GO:0006508//GO:0006446 translational initiation//proteolysis//regulation of translational initiation GO:0008236//GO:0003743//GO:0005515 serine-type peptidase activity//translation initiation factor activity//protein binding GO:0005840//GO:0005576 ribosome//extracellular region KOG2072 Translation initiation factor 3, subunit a (eIF-3a) Cluster-8309.37781 BF_2 100.18 0.46 9349 86515360 NP_001034507.1 1537 3.6e-167 dorsal [Tribolium castaneum]>gi|11496169|gb|AAG22858.1| Dorsal [Tribolium castaneum] 462460645 APGK01006274.1 58 2.4432e-18 Dendroctonus ponderosae Seq01006279, whole genome shotgun sequence K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 1100 7.0e-118 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF08050//PF10415//PF02894//PF01408//PF00554 Tetracycline resistance leader peptide//Fumarase C C-terminus//Oxidoreductase family, C-terminal alpha/beta domain//Oxidoreductase family, NAD-binding Rossmann fold//Rel homology DNA-binding domain GO:0006099//GO:0006355//GO:0046677//GO:0055114//GO:0008152 tricarboxylic acid cycle//regulation of transcription, DNA-templated//response to antibiotic//oxidation-reduction process//metabolic process GO:0016829//GO:0003700//GO:0003677//GO:0016491 lyase activity//transcription factor activity, sequence-specific DNA binding//DNA binding//oxidoreductase activity GO:0005667 transcription factor complex -- -- Cluster-8309.37783 BF_2 750.00 11.97 2908 642936145 XP_008198316.1 2403 4.3e-268 PREDICTED: protein TRC8 homolog [Tribolium castaneum]>gi|270014053|gb|EFA10501.1| hypothetical protein TcasGA2_TC012749 [Tribolium castaneum] 442621694 NM_001276141.1 123 5.54544e-55 Drosophila melanogaster Trc8 (Trc8), transcript variant E, mRNA K15703 RNF139, TRC8 E3 ubiquitin-protein ligase RNF139 http://www.genome.jp/dbget-bin/www_bget?ko:K15703 Q7KRW1 1573 3.1e-173 Protein TRC8 homolog OS=Drosophila melanogaster GN=Trc8 PE=1 SV=1 PF00097//PF14634//PF12906//PF17123//PF12678//PF12861//PF03854//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//P-11 zinc finger//Ring finger domain GO:0016567 protein ubiquitination GO:0005515//GO:0046872//GO:0004842//GO:0008270//GO:0003723 protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding//RNA binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.37784 BF_2 28.41 69.71 277 91088863 XP_971818.1 143 4.7e-07 PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932389|ref|XP_008197091.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932391|ref|XP_008197092.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|270011591|gb|EFA08039.1| hypothetical protein TcasGA2_TC005632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37786 BF_2 497.47 4.27 5156 642935312 XP_008197963.1 2087 3.3e-231 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.04617e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1142 5.2e-123 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF08702//PF00038//PF10186 Fibrinogen alpha/beta chain family//Intermediate filament protein//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0007165//GO:0051258//GO:0030168//GO:0010508 signal transduction//protein polymerization//platelet activation//positive regulation of autophagy GO:0005198//GO:0005102//GO:0030674 structural molecule activity//receptor binding//protein binding, bridging GO:0005882//GO:0005577 intermediate filament//fibrinogen complex -- -- Cluster-8309.37791 BF_2 382.88 4.36 3957 478254003 ENN74295.1 1276 2.8e-137 hypothetical protein YQE_09267, partial [Dendroctonus ponderosae]>gi|546673725|gb|ERL85281.1| hypothetical protein D910_02702 [Dendroctonus ponderosae] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 P13280 850 2.9e-89 Glycogenin-1 OS=Oryctolagus cuniculus GN=GYG1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.37792 BF_2 25.50 0.37 3180 642910776 XP_008193405.1 2513 8.3e-281 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 2.23022e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1134 2.7e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.37794 BF_2 43.36 0.56 3510 642921224 XP_008192769.1 1912 4.5e-211 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 302 2.09425e-154 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 3.1e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF14604//PF00018//PF00023//PF13606 Variant SH3 domain//SH3 domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.37795 BF_2 1373.57 34.18 1968 642910476 XP_008200230.1 1273 3.1e-137 PREDICTED: hrp65 protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 Q9U1N0 986 2.4e-105 Hrp65 protein OS=Chironomus tentans GN=HRP65 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0115 RNA-binding protein p54nrb (RRM superfamily) Cluster-8309.37796 BF_2 2057.73 9.91 8974 817065912 XP_012254772.1 7951 0.0e+00 PREDICTED: translational activator GCN1 [Athalia rosae] 820859669 XM_003697079.2 471 0 PREDICTED: Apis florea translational activator GCN1 (LOC100865997), mRNA -- -- -- -- Q92616 5791 0.0e+00 Translational activator GCN1 OS=Homo sapiens GN=GCN1L1 PE=1 SV=6 PF01602//PF00042//PF00125//PF02269//PF02985//PF08064 Adaptin N terminal region//Globin//Core histone H2A/H2B/H3/H4//Transcription initiation factor IID, 18kD subunit//HEAT repeat//UME (NUC010) domain GO:0009069//GO:0006886//GO:0016310//GO:0016192//GO:0006366 serine family amino acid metabolic process//intracellular protein transport//phosphorylation//vesicle-mediated transport//transcription from RNA polymerase II promoter GO:0020037//GO:0004674//GO:0003677//GO:0019825//GO:0005515 heme binding//protein serine/threonine kinase activity//DNA binding//oxygen binding//protein binding GO:0030117 membrane coat KOG1242 Protein containing adaptin N-terminal region Cluster-8309.37797 BF_2 2304.11 82.53 1455 91079304 XP_966317.1 1568 1.4e-171 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 647 3.7e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.37799 BF_2 1447.20 7.25 8643 307208309 EFN85734.1 1921 9.9e-212 Fatty acid synthase [Harpegnathos saltator] 815792597 XM_012361475.1 47 2.9416e-12 PREDICTED: Linepithema humile fatty acid synthase-like (LOC105668856), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1243 1.7e-134 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF05524//PF00107//PF02826//PF00106//PF00975 PEP-utilising enzyme, N-terminal//Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//short chain dehydrogenase//Thioesterase domain GO:0008152//GO:0009401//GO:0055114//GO:0009058 metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//oxidation-reduction process//biosynthetic process GO:0016788//GO:0051287//GO:0016491 hydrolase activity, acting on ester bonds//NAD binding//oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.37800 BF_2 1392.41 65.24 1180 478259299 ENN79201.1 662 1.3e-66 hypothetical protein YQE_04385, partial [Dendroctonus ponderosae]>gi|546681741|gb|ERL91773.1| hypothetical protein D910_09099 [Dendroctonus ponderosae] -- -- -- -- -- K05770 BZRP benzodiazapine receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05770 P16257 416 1.8e-39 Translocator protein OS=Rattus norvegicus GN=Tspo PE=1 SV=1 PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane KOG3797 Peripheral-type benzodiazepine receptor and related proteins Cluster-8309.37801 BF_2 251.39 2.04 5445 642928927 XP_008195620.1 2199 3.6e-244 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 282 4.27814e-143 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 559 2.2e-55 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37802 BF_2 1015.45 5.26 8367 91077082 XP_969760.1 2971 0.0e+00 PREDICTED: protein NRDE2 homolog [Tribolium castaneum]>gi|270002034|gb|EEZ98481.1| hypothetical protein TcasGA2_TC000974 [Tribolium castaneum] 742984403 CP010377.1 47 2.84726e-12 Enterobacter cloacae strain 34983, complete genome K03639 MOCS1, moaA cyclic pyranopterin phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K03639 Q8IQF1 1535 2.3e-168 Molybdenum cofactor biosynthesis protein 1 OS=Drosophila melanogaster GN=Mocs1 PE=2 SV=1 PF01967//PF15015//PF06463//PF00057//PF04055//PF05373 MoaC family//Spermatogenesis-associated, N-terminal//Molybdenum Cofactor Synthesis C//Low-density lipoprotein receptor domain class A//Radical SAM superfamily//L-proline 3-hydroxylase, C-terminal GO:0006777//GO:0007283//GO:0055114 Mo-molybdopterin cofactor biosynthetic process//spermatogenesis//oxidation-reduction process GO:0003824//GO:0005515//GO:0016706//GO:0051536//GO:0051539 catalytic activity//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron-sulfur cluster binding//4 iron, 4 sulfur cluster binding GO:0005794//GO:0019008 Golgi apparatus//molybdopterin synthase complex KOG2876 Molybdenum cofactor biosynthesis pathway protein Cluster-8309.37803 BF_2 452.35 3.46 5756 642921963 XP_008192963.1 2834 0.0e+00 PREDICTED: uncharacterized protein LOC658725 [Tribolium castaneum]>gi|270007382|gb|EFA03830.1| hypothetical protein TcasGA2_TC013946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.37804 BF_2 665.98 7.29 4111 642922741 XP_008193305.1 3310 0.0e+00 PREDICTED: dynamin-1-like protein isoform X1 [Tribolium castaneum]>gi|270007540|gb|EFA03988.1| hypothetical protein TcasGA2_TC014137 [Tribolium castaneum] 642922742 XM_001815078.2 425 0 PREDICTED: Tribolium castaneum dynamin-1-like protein (LOC660635), transcript variant X2, mRNA K17065 DNM1L dynamin 1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17065 O00429 2324 3.6e-260 Dynamin-1-like protein OS=Homo sapiens GN=DNM1L PE=1 SV=2 PF01926//PF01031//PF02212 50S ribosome-binding GTPase//Dynamin central region//Dynamin GTPase effector domain GO:0006184 obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.37805 BF_2 33.22 0.32 4658 642922741 XP_008193305.1 2492 3.3e-278 PREDICTED: dynamin-1-like protein isoform X1 [Tribolium castaneum]>gi|270007540|gb|EFA03988.1| hypothetical protein TcasGA2_TC014137 [Tribolium castaneum] 642922742 XM_001815078.2 425 0 PREDICTED: Tribolium castaneum dynamin-1-like protein (LOC660635), transcript variant X2, mRNA K17065 DNM1L dynamin 1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17065 O00429 1988 3.7e-221 Dynamin-1-like protein OS=Homo sapiens GN=DNM1L PE=1 SV=2 PF07355//PF01926//PF01031//PF02212 Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)//50S ribosome-binding GTPase//Dynamin central region//Dynamin GTPase effector domain GO:0055114//GO:0006184 oxidation-reduction process//obsolete GTP catabolic process GO:0003924//GO:0050485//GO:0005525 GTPase activity//oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.37806 BF_2 482.81 5.45 3991 189237265 XP_001815130.1 3218 0.0e+00 PREDICTED: dynamin-1-like protein isoform X2 [Tribolium castaneum] 642922742 XM_001815078.2 425 0 PREDICTED: Tribolium castaneum dynamin-1-like protein (LOC660635), transcript variant X2, mRNA K17065 DNM1L dynamin 1-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17065 O00429 2343 2.2e-262 Dynamin-1-like protein OS=Homo sapiens GN=DNM1L PE=1 SV=2 PF01031//PF01926//PF02212 Dynamin central region//50S ribosome-binding GTPase//Dynamin GTPase effector domain -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.37807 BF_2 5039.75 21.91 9911 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF01436//PF08165//PF00097//PF03884//PF01601//PF14634//PF00643//PF04566//PF10588//PF13639//PF04513//PF00651 NHL repeat//FerA (NUC095) domain//Zinc finger, C3HC4 type (RING finger)//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//B-box zinc finger//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Ring finger domain//Baculovirus polyhedron envelope protein, PEP, C terminus//BTB/POZ domain GO:0055114//GO:0006351//GO:0006144//GO:0061025//GO:0006206//GO:0046813 oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process//membrane fusion//pyrimidine nucleobase metabolic process//receptor-mediated virion attachment to host cell GO:0003899//GO:0005198//GO:0008270//GO:0003677//GO:0005515//GO:0016491//GO:0046872 DNA-directed RNA polymerase activity//structural molecule activity//zinc ion binding//DNA binding//protein binding//oxidoreductase activity//metal ion binding GO:0016021//GO:0019028//GO:0005622//GO:0005730//GO:0019031 integral component of membrane//viral capsid//intracellular//nucleolus//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37809 BF_2 364.27 5.28 3173 642932076 XP_008196848.1 1166 1.3e-124 PREDICTED: pre-mRNA-splicing regulator female-lethal(2)D [Tribolium castaneum]>gi|270011667|gb|EFA08115.1| hypothetical protein TcasGA2_TC005719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y091 702 3.4e-72 Pre-mRNA-splicing regulator female-lethal(2)D OS=Drosophila melanogaster GN=fl(2)d PE=1 SV=2 PF05791//PF17098//PF02932//PF09177//PF02050//PF07361//PF03233//PF09298 Bacillus haemolytic enterotoxin (HBL)//Pre-mRNA-splicing regulator WTAP//Neurotransmitter-gated ion-channel transmembrane region//Syntaxin 6, N-terminal//Flagellar FliJ protein//Cytochrome b562//Aphid transmission protein//Fumarylacetoacetase N-terminal GO:0006570//GO:0009405//GO:0042207//GO:0022900//GO:0006118//GO:0009072//GO:0019089//GO:0048193//GO:0071973//GO:0006935//GO:0006811//GO:0048024 tyrosine metabolic process//pathogenesis//styrene catabolic process//electron transport chain//obsolete electron transport//aromatic amino acid family metabolic process//transmission of virus//Golgi vesicle transport//bacterial-type flagellum-dependent cell motility//chemotaxis//ion transport//regulation of mRNA splicing, via spliceosome GO:0005506//GO:0004334//GO:0020037//GO:0003774//GO:0009055 iron ion binding//fumarylacetoacetase activity//heme binding//motor activity//electron carrier activity GO:0042597//GO:0009288//GO:0005634//GO:0016020 periplasmic space//bacterial-type flagellum//nucleus//membrane KOG2991 Splicing regulator Cluster-8309.37810 BF_2 76.02 0.94 3670 546673279 ERL84915.1 371 2.3e-32 hypothetical protein D910_02338 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37811 BF_2 3407.12 31.82 4767 699049757 AIU39233.1 742 2.8e-75 tropomyosin 1 [Monochamus alternatus] 699049756 KM099072.1 606 0 Monochamus alternatus tropomyosin 1 mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 Q1HPQ0 691 9.5e-71 Tropomyosin-2 OS=Bombyx mori PE=1 SV=1 PF04513//PF08702//PF02601//PF07926//PF16326//PF07851//PF06009//PF14073//PF11365//PF00769//PF15898//PF03577//PF05739//PF10473//PF06160//PF10186 Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//TPR/MLP1/MLP2-like protein//ABC transporter C-terminal domain//TMPIT-like protein//Laminin Domain II//Centrosome localisation domain of Cep57//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Peptidase family C69//SNARE domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0007165//GO:0051258//GO:0010508//GO:0007155//GO:0006308//GO:0010506//GO:0006606//GO:0000921//GO:0030168//GO:0006508 signal transduction//protein polymerization//positive regulation of autophagy//cell adhesion//DNA catabolic process//regulation of autophagy//protein import into nucleus//septin ring assembly//platelet activation//proteolysis GO:0005198//GO:0019901//GO:0016805//GO:0003677//GO:0042802//GO:0005515//GO:0008855//GO:0043015//GO:0042803//GO:0045502//GO:0008134//GO:0005102//GO:0008092//GO:0030674 structural molecule activity//protein kinase binding//dipeptidase activity//DNA binding//identical protein binding//protein binding//exodeoxyribonuclease VII activity//gamma-tubulin binding//protein homodimerization activity//dynein binding//transcription factor binding//receptor binding//cytoskeletal protein binding//protein binding, bridging GO:0016021//GO:0005940//GO:0005737//GO:0019031//GO:0019898//GO:0019028//GO:0045298//GO:0009318//GO:0005577//GO:0005615//GO:0030286//GO:0005667 integral component of membrane//septin ring//cytoplasm//viral envelope//extrinsic component of membrane//viral capsid//tubulin complex//exodeoxyribonuclease VII complex//fibrinogen complex//extracellular space//dynein complex//transcription factor complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.37812 BF_2 187.18 2.07 4061 642913457 XP_008201020.1 4068 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.1e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00784//PF00023//PF13606 MyTH4 domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.37813 BF_2 725.24 9.97 3331 91089287 XP_971047.1 863 1.8e-89 PREDICTED: derlin-2 [Tribolium castaneum]>gi|270012498|gb|EFA08946.1| hypothetical protein TcasGA2_TC006653 [Tribolium castaneum] 762105781 XR_901040.1 45 1.45736e-11 PREDICTED: Crassostrea gigas derlin-2-like (LOC105333927), transcript variant X2, misc_RNA K13989 DERL2_3 Derlin-2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K13989 Q8BNI4 746 2.8e-77 Derlin-2 OS=Mus musculus GN=Derl2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0858 Predicted membrane protein Cluster-8309.37815 BF_2 1269.56 25.78 2347 642920110 XP_008192209.1 1271 6.3e-137 PREDICTED: putative oxidoreductase GLYR1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q161 831 2.7e-87 Putative oxidoreductase GLYR1 homolog OS=Anopheles gambiae GN=AGAP009949 PE=3 SV=5 PF13241//PF03435//PF02558//PF01210//PF03446//PF02826//PF02737//PF14833//PF16519 Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//Ketopantoate reductase PanE/ApbA//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Tetramerisation domain of TRPM GO:0015940//GO:0006574//GO:0006550//GO:0051262//GO:0006779//GO:0006554//GO:0055114//GO:0006568//GO:0019521//GO:0046168//GO:0019354//GO:0006098//GO:0006633//GO:0018874//GO:0006552//GO:0006631 pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//protein tetramerization//porphyrin-containing compound biosynthetic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//D-gluconate metabolic process//glycerol-3-phosphate catabolic process//siroheme biosynthetic process//pentose-phosphate shunt//fatty acid biosynthetic process//benzoate metabolic process//leucine catabolic process//fatty acid metabolic process GO:0016616//GO:0004616//GO:0003857//GO:0016491//GO:0051287//GO:0043115//GO:0008677 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//NAD binding//precorrin-2 dehydrogenase activity//2-dehydropantoate 2-reductase activity -- -- KOG0409 Predicted dehydrogenase Cluster-8309.37816 BF_2 24.27 2.14 762 270002078 EEZ98525.1 188 7.8e-12 hypothetical protein TcasGA2_TC001029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37817 BF_2 2055.73 48.81 2049 91077452 XP_967401.1 1566 3.4e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.1e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF01370//PF13676//PF00106 NAD dependent epimerase/dehydratase family//TIR domain//short chain dehydrogenase GO:0055114//GO:0007165//GO:0008152 oxidation-reduction process//signal transduction//metabolic process GO:0000166//GO:0050662//GO:0003824//GO:0016491//GO:0005515 nucleotide binding//coenzyme binding//catalytic activity//oxidoreductase activity//protein binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.37818 BF_2 627.75 3.82 7165 91088413 XP_966659.1 4529 0.0e+00 PREDICTED: TATA-binding protein-associated factor 172 [Tribolium castaneum]>gi|270011757|gb|EFA08205.1| hypothetical protein TcasGA2_TC005832 [Tribolium castaneum] 831521961 XM_012862362.1 245 2.08524e-122 PREDICTED: Fundulus heteroclitus BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (btaf1), mRNA K15192 BTAF1, MOT1 TATA-binding protein-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15192 O14981 2080 1.2e-231 TATA-binding protein-associated factor 172 OS=Homo sapiens GN=BTAF1 PE=1 SV=2 PF15247//PF02262//PF00176//PF02985 Histone RNA hairpin-binding protein RNA-binding domain//CBL proto-oncogene N-terminal domain 1//SNF2 family N-terminal domain//HEAT repeat GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0005515//GO:0004386//GO:0003723//GO:0005524//GO:0003677//GO:0004871 protein binding//helicase activity//RNA binding//ATP binding//DNA binding//signal transducer activity GO:0005634 nucleus KOG0392 SNF2 family DNA-dependent ATPase domain-containing protein Cluster-8309.37819 BF_2 782.05 15.40 2412 642916810 XP_967695.2 1570 1.4e-171 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 1086 7.6e-117 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0015979//GO:0050821 photosynthesis//protein stabilization GO:0042301//GO:0005515 phosphate ion binding//protein binding GO:0016020//GO:0009523 membrane//photosystem II KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.3782 BF_2 10.51 0.37 1491 1706197 P80684.1 288 3.9e-23 RecName: Full=Pupal cuticle protein C1B; AltName: Full=TM-PCP C1B; Short=TM-C1B [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P80684 288 1.6e-24 Pupal cuticle protein C1B OS=Tenebrio molitor PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37820 BF_2 3157.00 56.47 2626 189237512 XP_972880.2 1894 4.1e-209 PREDICTED: protein phosphatase 1L [Tribolium castaneum]>gi|270007703|gb|EFA04151.1| hypothetical protein TcasGA2_TC014396 [Tribolium castaneum] -- -- -- -- -- K17506 PPM1L, PP2CE protein phosphatase 1L http://www.genome.jp/dbget-bin/www_bget?ko:K17506 Q5SGD2 646 8.7e-66 Protein phosphatase 1L OS=Homo sapiens GN=PPM1L PE=1 SV=1 PF00481 Protein phosphatase 2C GO:0006470 protein dephosphorylation GO:0046872//GO:0004722//GO:0003824 metal ion binding//protein serine/threonine phosphatase activity//catalytic activity GO:0008287 protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.37821 BF_2 68.33 0.71 4289 642926721 XP_008194985.1 1671 4.8e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.1e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.37822 BF_2 768.66 4.06 8211 642930614 XP_008199194.1 1174 3.9e-125 PREDICTED: protein winged eye isoform X1 [Tribolium castaneum]>gi|642930616|ref|XP_967104.2| PREDICTED: protein winged eye isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3LHL9 631 1.5e-63 Protein winged eye OS=Drosophila melanogaster GN=wge PE=1 SV=1 PF01426//PF13181 BAH domain//Tetratricopeptide repeat -- -- GO:0003682//GO:0005515 chromatin binding//protein binding GO:0000785 chromatin -- -- Cluster-8309.37823 BF_2 104.56 1.20 3932 91090988 XP_974875.1 1812 2.0e-199 PREDICTED: nucleolar protein 14 homolog [Tribolium castaneum]>gi|270014041|gb|EFA10489.1| hypothetical protein TcasGA2_TC012735 [Tribolium castaneum] -- -- -- -- -- K14766 NOP14, UTP2 nucleolar protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K14766 Q9VEJ2 1319 1.2e-143 Nucleolar protein 14 homolog OS=Drosophila melanogaster GN=l(3)07882 PE=2 SV=2 PF08361//PF05859//PF04147 MAATS-type transcriptional repressor, C-terminal region//Mis12 protein//Nop14-like family GO:0007067//GO:0007049 mitotic nuclear division//cell cycle GO:0003677 DNA binding GO:0000775//GO:0005634//GO:0032040 chromosome, centromeric region//nucleus//small-subunit processome KOG2147 Nucleolar protein involved in 40S ribosome biogenesis Cluster-8309.37824 BF_2 2592.40 44.78 2709 91086225 XP_972341.1 3612 0.0e+00 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 766937068 XM_011502671.1 253 2.7935e-127 PREDICTED: Ceratosolen solmsi marchali dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B (LOC105364681), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 2906 0.0e+00 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0016020//GO:0008250 membrane//oligosaccharyltransferase complex KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.37825 BF_2 332.84 1.03 13828 546673612 ERL85176.1 14419 0.0e+00 hypothetical protein D910_02598 [Dendroctonus ponderosae] 642911110 XM_008202361.1 2796 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 6543 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF01108//PF00041//PF13895//PF01300//PF16656//PF15170//PF01891//PF16794//PF02480 Tissue factor//Fibronectin type III domain//Immunoglobulin domain//Telomere recombination//Purple acid Phosphatase, N-terminal domain//Calcium/calmodulin-dependent protein kinase II inhibitor//Cobalt uptake substrate-specific transmembrane region//Fibronectin-III type domain//Alphaherpesvirus glycoprotein E GO:0000041//GO:0006771//GO:0019497//GO:0045859 transition metal ion transport//riboflavin metabolic process//hexachlorocyclohexane metabolic process//regulation of protein kinase activity GO:0003993//GO:0046872//GO:0003725//GO:0004860//GO:0005515 acid phosphatase activity//metal ion binding//double-stranded RNA binding//protein kinase inhibitor activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.37826 BF_2 1018.00 13.12 3532 91094575 XP_968718.1 3629 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 1 [Tribolium castaneum]>gi|270016394|gb|EFA12840.1| hypothetical protein TcasGA2_TC006940 [Tribolium castaneum] 410922466 XM_003974655.1 72 1.51379e-26 PREDICTED: Takifugu rubripes protein kinase, cGMP-dependent, type II (prkg2), mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03042 2137 1.5e-238 cGMP-dependent protein kinase, isozyme 1 OS=Drosophila melanogaster GN=Pkg21D PE=1 SV=2 PF00069//PF00125//PF07851//PF06156//PF07714 Protein kinase domain//Core histone H2A/H2B/H3/H4//TMPIT-like protein//Protein of unknown function (DUF972)//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310//GO:0006260 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//DNA replication GO:0004692//GO:0005524//GO:0003677//GO:0004672 cGMP-dependent protein kinase activity//ATP binding//DNA binding//protein kinase activity GO:0016021 integral component of membrane KOG0614 cGMP-dependent protein kinase Cluster-8309.37827 BF_2 5.00 1.04 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37828 BF_2 5189.56 33.48 6771 91085003 XP_973266.1 2982 0.0e+00 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 194742159 XM_001953538.1 227 1.99805e-112 Drosophila ananassae GF17161 (Dana\GF17161), mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 2563 1.2e-287 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF00439//PF05693//PF02535 Bromodomain//Glycogen synthase//ZIP Zinc transporter GO:0005985//GO:0055085//GO:0030001//GO:0005982//GO:0005978 sucrose metabolic process//transmembrane transport//metal ion transport//starch metabolic process//glycogen biosynthetic process GO:0004373//GO:0005515//GO:0046873 glycogen (starch) synthase activity//protein binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3742 Glycogen synthase Cluster-8309.37829 BF_2 80.22 0.47 7407 478263554 ENN81890.1 1552 5.2e-169 hypothetical protein YQE_01728, partial [Dendroctonus ponderosae] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q9XZ43 1076 3.4e-115 Protein 5NUC OS=Lutzomyia longipalpis GN=5NUC PE=1 SV=1 PF02872//PF00149//PF03615 5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase//GCM motif protein GO:0006355//GO:0009166 regulation of transcription, DNA-templated//nucleotide catabolic process GO:0003677//GO:0016787 DNA binding//hydrolase activity -- -- -- -- Cluster-8309.37830 BF_2 1905.80 13.00 6419 270007552 EFA04000.1 1548 1.3e-168 hypothetical protein TcasGA2_TC014149 [Tribolium castaneum] 642922772 XM_008195097.1 443 0 PREDICTED: Tribolium castaneum protein muscleblind (LOC100142119), mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 771 6.8e-80 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF00642//PF06733 MMPL family//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//DEAD_2 -- -- GO:0046872//GO:0005524//GO:0004003//GO:0003677 metal ion binding//ATP binding//ATP-dependent DNA helicase activity//DNA binding GO:0005657//GO:0016020 replication fork//membrane KOG2494 C3H1-type Zn-finger protein Cluster-8309.37832 BF_2 1198.00 37.57 1621 91076490 XP_972861.1 387 1.4e-34 PREDICTED: CD81 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZR9 146 5.1e-08 Tetraspanin-3 OS=Bos taurus GN=TSPAN3 PE=2 SV=1 PF00335//PF00003//PF12632//PF04103 Tetraspanin family//7 transmembrane sweet-taste receptor of 3 GCPR//Mysoin-binding motif of peroxisomes//CD20-like family GO:0007186 G-protein coupled receptor signaling pathway GO:0017022//GO:0004930 myosin binding//G-protein coupled receptor activity GO:0016021//GO:0016459 integral component of membrane//myosin complex KOG3882 Tetraspanin family integral membrane protein Cluster-8309.37833 BF_2 2261.00 45.26 2377 91079768 XP_966889.1 839 8.0e-87 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 P70684 395 1.0e-36 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Cavia porcellus GN=HPGD PE=2 SV=1 PF01370//PF01073//PF00106 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008210//GO:0008152 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//estrogen metabolic process//metabolic process GO:0000166//GO:0003854//GO:0003824//GO:0050662//GO:0016491//GO:0016616 nucleotide binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.37834 BF_2 1352.00 37.26 1805 167234380 NP_001107813.1 1462 3.5e-159 glass bottom boat protein precursor [Tribolium castaneum]>gi|270008197|gb|EFA04645.1| glass bottom boat [Tribolium castaneum] 736191339 XM_010773191.1 51 3.61777e-15 PREDICTED: Notothenia coriiceps bone morphogenetic protein 5 (bmp5), transcript variant X2, mRNA K16621 BMP7 bone morphogenetic protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K16621 P27091 929 9.1e-99 Protein 60A OS=Drosophila melanogaster GN=gbb PE=1 SV=1 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083 growth factor activity GO:0005576 extracellular region -- -- Cluster-8309.37835 BF_2 4.49 0.31 889 91085777 XP_974360.1 549 1.3e-53 PREDICTED: 60S ribosomal protein L23 [Tribolium castaneum]>gi|270010126|gb|EFA06574.1| hypothetical protein TcasGA2_TC009485 [Tribolium castaneum] 110671519 DQ673438.1 126 3.55058e-57 Diaphorina citri putative ribosomal protein L17/23 mRNA, complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P48159 523 5.4e-52 60S ribosomal protein L23 OS=Drosophila melanogaster GN=RpL23 PE=1 SV=2 PF17123//PF00238//PF09254 RING-like zinc finger//Ribosomal protein L14p/L23e//Restriction endonuclease FokI, C terminal GO:0042254//GO:0006308//GO:0009307//GO:0006412 ribosome biogenesis//DNA catabolic process//DNA restriction-modification system//translation GO:0003735//GO:0008270//GO:0005515//GO:0009036//GO:0003677 structural constituent of ribosome//zinc ion binding//protein binding//Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359//GO:0005840 Type II site-specific deoxyribonuclease complex//ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.37836 BF_2 6099.82 50.75 5315 642912047 XP_008199070.1 2723 6.1e-305 PREDICTED: nuclear factor 1 C-type isoform X1 [Tribolium castaneum]>gi|270014496|gb|EFA10944.1| hypothetical protein TcasGA2_TC001775 [Tribolium castaneum] 642912046 XM_008200848.1 847 0 PREDICTED: Tribolium castaneum nuclear factor 1 C-type (LOC660261), transcript variant X1, mRNA K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 P09414 752 9.0e-78 Nuclear factor 1 A-type OS=Rattus norvegicus GN=Nfia PE=1 SV=2 PF00859//PF03165 CTF/NF-I family transcription modulation region//MH1 domain GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005622//GO:0005667 nucleus//intracellular//transcription factor complex KOG3663 Nuclear factor I Cluster-8309.37839 BF_2 370.14 2.77 5876 350409232 XP_003488663.1 2292 6.4e-255 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 2 [Bombus impatiens] 642920726 XM_964528.3 475 0 PREDICTED: Tribolium castaneum polypeptide N-acetylgalactosaminyltransferase 2 (LOC658118), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV19 2013 6.0e-224 Polypeptide N-acetylgalactosaminyltransferase 2 OS=Drosophila melanogaster GN=pgant2 PE=2 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.37840 BF_2 82.31 1.21 3122 642911649 XP_008200687.1 769 1.4e-78 PREDICTED: synapse-associated protein of 47 kDa isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 415 6.3e-39 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.37841 BF_2 25.95 0.41 2909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37845 BF_2 122.65 7.87 939 642913592 XP_008201077.1 412 1.0e-37 PREDICTED: dentin sialophosphoprotein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37846 BF_2 579.27 2.46 10130 642935327 XP_001809480.2 2489 1.6e-277 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 541 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF00651//PF04513//PF13639//PF10588//PF03884//PF01601//PF14634//PF00097//PF01436 BTB/POZ domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Ring finger domain//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//NHL repeat GO:0061025//GO:0046813//GO:0055114 membrane fusion//receptor-mediated virion attachment to host cell//oxidation-reduction process GO:0005198//GO:0005515//GO:0016491//GO:0008270//GO:0046872 structural molecule activity//protein binding//oxidoreductase activity//zinc ion binding//metal ion binding GO:0019028//GO:0016021//GO:0019031 viral capsid//integral component of membrane//viral envelope KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.37847 BF_2 245.06 14.40 999 91089633 XP_973579.1 1132 3.5e-121 PREDICTED: guanine nucleotide-binding protein subunit beta-like protein isoform X1 [Tribolium castaneum]>gi|270012613|gb|EFA09061.1| hypothetical protein TcasGA2_TC006776 [Tribolium castaneum] 389610732 AK402355.1 167 6.47271e-80 Papilio polytes mRNA for receptor of activated protein kinase C 1, complete cds, sequence id: Pp-0111 K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 O18640 1017 3.1e-109 Guanine nucleotide-binding protein subunit beta-like protein OS=Drosophila melanogaster GN=Rack1 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.37848 BF_2 95.00 4.28 1216 478252244 ENN72672.1 741 9.4e-76 hypothetical protein YQE_10770, partial [Dendroctonus ponderosae]>gi|546675735|gb|ERL86867.1| hypothetical protein D910_04270 [Dendroctonus ponderosae] -- -- -- -- -- K10712 ADO cysteamine dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K10712 Q96SZ5 294 2.6e-25 2-aminoethanethiol dioxygenase OS=Homo sapiens GN=ADO PE=1 SV=2 PF05995//PF07847//PF16867 Cysteine dioxygenase type I//Protein of unknown function (DUF1637)//Dimethlysulfonioproprionate lyase GO:0019530//GO:0006534//GO:0046439//GO:0055114 taurine metabolic process//cysteine metabolic process//L-cysteine metabolic process//oxidation-reduction process GO:0017172//GO:0016702//GO:0005506//GO:0047869 cysteine dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//iron ion binding//dimethylpropiothetin dethiomethylase activity -- -- KOG4281 Uncharacterized conserved protein Cluster-8309.37849 BF_2 1916.48 45.84 2036 642929992 XP_975639.2 932 1.1e-97 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6V5K9 261 3.0e-21 Zinc finger protein 474 OS=Mus musculus GN=Znf474 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37850 BF_2 61.26 1.45 2049 642929992 XP_975639.2 932 1.1e-97 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6V5K9 261 3.0e-21 Zinc finger protein 474 OS=Mus musculus GN=Znf474 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37851 BF_2 183.30 20.57 660 642929992 XP_975639.2 682 3.5e-69 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QQM4 294 1.4e-25 Zinc finger protein 474 OS=Bos taurus GN=ZNF474 PE=2 SV=1 PF16622//PF01428//PF13465 zinc-finger C2H2-type//AN1-like Zinc finger//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.37853 BF_2 328.33 2.61 5542 642923911 XP_008193924.1 2383 1.7e-265 PREDICTED: nucleolar protein 10 [Tribolium castaneum]>gi|270007790|gb|EFA04238.1| hypothetical protein TcasGA2_TC014492 [Tribolium castaneum] 817185075 XM_012429433.1 112 1.38501e-48 PREDICTED: Orussus abietinus nucleolar protein 10 (LOC105702116), transcript variant X1, mRNA K14788 NOL10, ENP2 ribosome biogenesis protein ENP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14788 Q7T0Q5 1808 3.3e-200 Nucleolar protein 10 OS=Xenopus laevis GN=nol10 PE=2 SV=1 PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus KOG2321 WD40 repeat protein Cluster-8309.37857 BF_2 292.33 2.94 4440 642913173 XP_008201422.1 3528 0.0e+00 PREDICTED: uncharacterized protein LOC663955 isoform X1 [Tribolium castaneum] 645014380 XM_008205235.1 470 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q10057 146 1.4e-07 Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F5.02 PE=3 SV=1 PF00085//PF02382//PF02020//PF01791 Thioredoxin//RTX N-terminal domain//eIF4-gamma/eIF5/eIF2-epsilon//DeoC/LacD family aldolase GO:0045454//GO:0009405 cell redox homeostasis//pathogenesis GO:0005515//GO:0016829//GO:0005509 protein binding//lyase activity//calcium ion binding GO:0005576 extracellular region KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.37859 BF_2 12.89 0.40 1621 795021508 XP_011860288.1 1147 1.0e-122 PREDICTED: putative uncharacterized protein FLJ37770 [Vollenhovia emeryi] 795018260 XM_012003757.1 973 0 PREDICTED: Vollenhovia emeryi putative uncharacterized protein FLJ37770 (LOC105556663), mRNA -- -- -- -- Q7JQ07 342 9.5e-31 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF02070 Neuromedin U GO:0006940 regulation of smooth muscle contraction -- -- -- -- -- -- Cluster-8309.37864 BF_2 36.03 1.18 1568 478250009 ENN70515.1 416 5.9e-38 hypothetical protein YQE_12691, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VTI8 264 1.0e-21 Protein charybde OS=Drosophila melanogaster GN=chrb PE=2 SV=2 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.37865 BF_2 1352.22 11.52 5196 546677674 ERL88468.1 4240 0.0e+00 hypothetical protein D910_05854 [Dendroctonus ponderosae] 807042134 XM_004536258.2 113 3.60886e-49 PREDICTED: Ceratitis capitata DNA-directed RNA polymerase I subunit RPA2 (LOC101449376), mRNA K03002 RPA2, POLR1B DNA-directed RNA polymerase I subunit RPA2 http://www.genome.jp/dbget-bin/www_bget?ko:K03002 P20028 3304 0.0e+00 DNA-directed RNA polymerase I subunit RPA2 OS=Drosophila melanogaster GN=RpI135 PE=2 SV=2 PF04560//PF00562//PF06883//PF04565//PF00034//PF04561//PF04563//PF13442 RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 6//RNA polymerase I, Rpa2 specific domain//RNA polymerase Rpb2, domain 3//Cytochrome c//RNA polymerase Rpb2, domain 2//RNA polymerase beta subunit//Cytochrome C oxidase, cbb3-type, subunit III GO:0006206//GO:0006118//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//obsolete electron transport//transcription, DNA-templated//purine nucleobase metabolic process GO:0009055//GO:0020037//GO:0003677//GO:0003899 electron carrier activity//heme binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus KOG0216 RNA polymerase I, second largest subunit Cluster-8309.37866 BF_2 505.45 18.04 1459 642926071 XP_008194753.1 1793 1.2e-197 PREDICTED: transcription elongation factor SPT5 [Tribolium castaneum]>gi|270008998|gb|EFA05446.1| hypothetical protein TcasGA2_TC015626 [Tribolium castaneum] -- -- -- -- -- K15172 SUPT5H, SPT5 transcription elongation factor SPT5 http://www.genome.jp/dbget-bin/www_bget?ko:K15172 Q9V460 1020 2.1e-109 Transcription elongation factor SPT5 OS=Drosophila melanogaster GN=Spt5 PE=1 SV=1 -- -- GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter -- -- -- -- KOG1999 RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 Cluster-8309.37867 BF_2 298.12 14.24 1163 270007560 EFA04008.1 467 5.3e-44 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 267 3.4e-22 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37869 BF_2 19.88 0.63 1610 195118931 XP_002003985.1 1290 2.7e-139 GI20096 [Drosophila mojavensis]>gi|193914560|gb|EDW13427.1| GI20096 [Drosophila mojavensis] 158296763 XM_317113.3 187 8.04942e-91 Anopheles gambiae str. PEST AGAP008345-PA (AgaP_AGAP008345) mRNA, complete cds K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 C1HAB2 966 4.2e-103 Methionine aminopeptidase 2 OS=Paracoccidioides lutzii (strain ATCC MYA-826 / Pb01) GN=PAAG_07566 PE=3 SV=1 PF03839//PF02724//PF00283 Translocation protein Sec62//CDC45-like protein//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits GO:0015031//GO:0006270//GO:0015979 protein transport//DNA replication initiation//photosynthesis GO:0008238//GO:0008565 exopeptidase activity//protein transporter activity GO:0016021 integral component of membrane KOG2775 Metallopeptidase Cluster-8309.37870 BF_2 222.50 2.88 3519 642937910 XP_008200354.1 2218 1.5e-246 PREDICTED: zinc finger RNA-binding protein [Tribolium castaneum] 642937909 XM_008202132.1 512 0 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q96KR1 745 3.9e-77 Zinc finger RNA-binding protein OS=Homo sapiens GN=ZFR PE=1 SV=2 PF06220//PF00096 U1 zinc finger//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.37871 BF_2 66.02 1.92 1725 642912068 XP_008200785.1 1434 5.9e-156 PREDICTED: peroxidase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 1.8e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.37873 BF_2 26.19 0.41 2937 91087199 XP_966953.1 1887 3.0e-208 PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|642929856|ref|XP_008196002.1| PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|270009518|gb|EFA05966.1| hypothetical protein TcasGA2_TC008785 [Tribolium castaneum] -- -- -- -- -- K17917 SNX1_2 sorting nexin-1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17917 Q9CWK8 1113 6.8e-120 Sorting nexin-2 OS=Mus musculus GN=Snx2 PE=1 SV=2 PF00787//PF00782//PF01025 PX domain//Dual specificity phosphatase, catalytic domain//GrpE GO:0007154//GO:0006470//GO:0006457 cell communication//protein dephosphorylation//protein folding GO:0000774//GO:0051087//GO:0042803//GO:0008138//GO:0035091 adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity//protein tyrosine/serine/threonine phosphatase activity//phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.37875 BF_2 213.63 3.31 2984 642919664 XP_008192013.1 934 9.6e-98 PREDICTED: gamma-sarcoglycan [Tribolium castaneum]>gi|270005447|gb|EFA01895.1| hypothetical protein TcasGA2_TC007505 [Tribolium castaneum] -- -- -- -- -- K12563 SGCD delta-sarcoglycan http://www.genome.jp/dbget-bin/www_bget?ko:K12563 P82348 445 2.0e-42 Gamma-sarcoglycan OS=Mus musculus GN=Sgcg PE=1 SV=2 PF04790 Sarcoglycan complex subunit protein -- -- -- -- GO:0016021//GO:0044425//GO:0016012 integral component of membrane//membrane part//sarcoglycan complex KOG3950 Gamma/delta sarcoglycan Cluster-8309.37876 BF_2 8.00 1.30 544 642920916 XP_008192614.1 161 7.6e-09 PREDICTED: outer dense fiber protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37877 BF_2 534.24 12.49 2077 642920914 XP_008192613.1 587 1.2e-57 PREDICTED: outer dense fiber protein 3-B isoform X2 [Tribolium castaneum]>gi|270006132|gb|EFA02580.1| hypothetical protein TcasGA2_TC008298 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 252 3.3e-20 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37878 BF_2 892.08 10.31 3905 91090754 XP_968387.1 495 1.0e-46 PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935819|ref|XP_008198188.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|642935821|ref|XP_008198189.1| PREDICTED: ADP-ribosylation factor 1 [Tribolium castaneum]>gi|270013960|gb|EFA10408.1| hypothetical protein TcasGA2_TC012647 [Tribolium castaneum] 760445534 XM_011401534.1 51 7.9055e-15 Auxenochlorella protothecoides ADP-ribosylation factor 1 partial mRNA K07937 ARF1 ADP-ribosylation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07937 P61209 488 2.7e-47 ADP-ribosylation factor 1 OS=Drosophila melanogaster GN=Arf79F PE=2 SV=2 PF00025//PF05493 ADP-ribosylation factor family//ATP synthase subunit H GO:0015991//GO:0007264//GO:0015992 ATP hydrolysis coupled proton transport//small GTPase mediated signal transduction//proton transport GO:0015078//GO:0005525 hydrogen ion transmembrane transporter activity//GTP binding GO:0005622//GO:0033179 intracellular//proton-transporting V-type ATPase, V0 domain KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.37880 BF_2 3375.35 54.88 2860 817087360 XP_012266451.1 2016 3.2e-223 PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae]>gi|817087362|ref|XP_012266452.1| PREDICTED: putative ATP-dependent RNA helicase me31b [Athalia rosae] 158299880 XM_319893.4 460 0 Anopheles gambiae str. PEST AGAP009135-PA (AgaP_AGAP009135) mRNA, partial cds K12614 DDX6, RCK, DHH1 ATP-dependent RNA helicase DDX6/DHH1 http://www.genome.jp/dbget-bin/www_bget?ko:K12614 P23128 1902 2.2e-211 Putative ATP-dependent RNA helicase me31b OS=Drosophila melanogaster GN=me31B PE=1 SV=3 PF08168//PF06221//PF00096//PF00270 NUC205 domain//Putative zinc finger motif, C2HC5-type//Zinc finger, C2H2 type//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0005524//GO:0003676 metal ion binding//zinc ion binding//ATP binding//nucleic acid binding GO:0005634 nucleus KOG0326 ATP-dependent RNA helicase Cluster-8309.37882 BF_2 123.27 1.16 4729 642931522 XP_008196620.1 1438 5.5e-156 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 1029 6.1e-110 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00640//PF00288 Phosphotyrosine interaction domain (PTB/PID)//GHMP kinases N terminal domain GO:0006012//GO:0046835 galactose metabolic process//carbohydrate phosphorylation GO:0005524//GO:0004335//GO:0005515 ATP binding//galactokinase activity//protein binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.37885 BF_2 275.43 2.00 6049 642923511 XP_008193539.1 1638 4.5e-179 PREDICTED: pH-response transcription factor pacC/RIM101-like isoform X1 [Tribolium castaneum]>gi|270006994|gb|EFA03442.1| hypothetical protein TcasGA2_TC013432 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14872 837 1.4e-87 Metal regulatory transcription factor 1 OS=Homo sapiens GN=MTF1 PE=1 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.37888 BF_2 1733.33 41.30 2043 91082437 XP_970911.1 1132 7.3e-121 PREDICTED: tribbles homolog 2 [Tribolium castaneum] 645019257 XM_001600513.3 107 3.0409e-46 PREDICTED: Nasonia vitripennis tribbles homolog 2-like (LOC100115993), mRNA K08814 TRIB1_2 tribbles homolog 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08814 Q8K4K3 606 2.9e-61 Tribbles homolog 2 OS=Mus musculus GN=Trib2 PE=2 SV=2 PF00539//PF03283//PF07714//PF00069 Transactivating regulatory protein (Tat)//Pectinacetylesterase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0006355 protein phosphorylation//regulation of transcription, DNA-templated GO:0016787//GO:0005524//GO:0004672//GO:0003700 hydrolase activity//ATP binding//protein kinase activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG0583 Serine/threonine protein kinase Cluster-8309.37890 BF_2 898.13 15.64 2690 91087173 XP_975394.1 1602 3.0e-175 PREDICTED: E3 ubiquitin-protein ligase MYLIP [Tribolium castaneum]>gi|270009571|gb|EFA06019.1| hypothetical protein TcasGA2_TC008849 [Tribolium castaneum] -- -- -- -- -- K10637 MYLIP, MIR E3 ubiquitin-protein ligase MYLIP http://www.genome.jp/dbget-bin/www_bget?ko:K10637 Q8WY64 805 3.2e-84 E3 ubiquitin-protein ligase MYLIP OS=Homo sapiens GN=MYLIP PE=1 SV=2 PF00097//PF14634//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ring finger domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.37891 BF_2 168.90 2.00 3812 270011657 EFA08105.1 1533 4.3e-167 hypothetical protein TcasGA2_TC005709 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.25505e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.9e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF01213//PF00622//PF07525 Adenylate cyclase associated (CAP) N terminal//SPRY domain//SOCS box GO:0007010//GO:0035556 cytoskeleton organization//intracellular signal transduction GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.37892 BF_2 140.00 19.34 590 478255041 ENN75273.1 888 4.1e-93 hypothetical protein YQE_08189, partial [Dendroctonus ponderosae]>gi|546673329|gb|ERL84957.1| hypothetical protein D910_02380 [Dendroctonus ponderosae] 657554958 XM_008283745.1 141 1.05914e-65 PREDICTED: Stegastes partitus phenylalanyl-tRNA synthetase, alpha subunit (farsa), mRNA K01889 FARSA, pheS phenylalanyl-tRNA synthetase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01889 Q9W3J5 814 6.4e-86 Phenylalanine--tRNA ligase alpha subunit OS=Drosophila melanogaster GN=alpha-PheRS PE=1 SV=1 PF01409//PF15048//PF00152//PF00587 tRNA synthetases class II core domain (F)//Organic solute transporter subunit beta protein//tRNA synthetases class II (D, K and N)//tRNA synthetase class II core domain (G, H, P, S and T) GO:0006810//GO:0015721//GO:0006418//GO:0043039 transport//bile acid and bile salt transport//tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0005524//GO:0046982//GO:0000049//GO:0005215//GO:0000166//GO:0004812 ATP binding//protein heterodimerization activity//tRNA binding//transporter activity//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005886//GO:0005737 plasma membrane//cytoplasm KOG2784 Phenylalanyl-tRNA synthetase, beta subunit Cluster-8309.37894 BF_2 17.60 1.13 941 642937480 XP_008198856.1 195 1.5e-12 PREDICTED: protein tramtrack, beta isoform-like isoform X17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37895 BF_2 2593.88 32.82 3593 91090686 XP_974615.1 1908 1.3e-210 PREDICTED: FGGY carbohydrate kinase domain-containing protein [Tribolium castaneum]>gi|270013302|gb|EFA09750.1| hypothetical protein TcasGA2_TC011889 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCD1 1405 1.2e-153 FGGY carbohydrate kinase domain-containing protein OS=Xenopus laevis GN=fggy PE=2 SV=2 PF00370//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.37900 BF_2 2116.68 13.85 6681 91076704 XP_972106.1 1365 2.3e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 7.1e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF13371//PF08030//PF04142//PF08449//PF10147//PF16685//PF13639//PF14634//PF12678//PF00097//PF01297//PF00892//PF00175 Tetratricopeptide repeat//Ferric reductase NAD binding domain//Nucleotide-sugar transporter//UAA transporter family//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-uptake complex component A periplasmic//EamA-like transporter family//Oxidoreductase NAD-binding domain GO:0055085//GO:0007049//GO:0015780//GO:0055114//GO:0030001//GO:0008643 transmembrane transport//cell cycle//nucleotide-sugar transport//oxidation-reduction process//metal ion transport//carbohydrate transport GO:0005351//GO:0005338//GO:0008270//GO:0061630//GO:0016491//GO:0005515//GO:0046872 sugar:proton symporter activity//nucleotide-sugar transmembrane transporter activity//zinc ion binding//ubiquitin protein ligase activity//oxidoreductase activity//protein binding//metal ion binding GO:0016021//GO:0005634//GO:0000139//GO:0016020 integral component of membrane//nucleus//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.37901 BF_2 1422.58 12.05 5226 749735952 XP_011154160.1 3304 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X1 [Harpegnathos saltator]>gi|307212553|gb|EFN88276.1| Armadillo segment polarity protein [Harpegnathos saltator] 642934620 XM_008199519.1 628 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 3204 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF02985//PF07646//PF10508//PF00514//PF01344//PF01602 HEAT repeat//Kelch motif//Proteasome non-ATPase 26S subunit//Armadillo/beta-catenin-like repeat//Kelch motif//Adaptin N terminal region GO:0043248//GO:0016192//GO:0006886 proteasome assembly//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.37902 BF_2 10.77 0.37 1496 642935880 XP_008198210.1 412 1.6e-37 PREDICTED: uncharacterized protein LOC103314310 [Tribolium castaneum] 642935879 XM_008199988.1 39 1.3992e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103314310 (LOC103314310), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37905 BF_2 508.60 11.18 2191 270006638 EFA03086.1 1933 1.0e-213 hypothetical protein TcasGA2_TC012992 [Tribolium castaneum] 642925120 XM_008195954.1 504 0 PREDICTED: Tribolium castaneum YTH domain-containing family protein 3 (LOC659651), transcript variant X1, mRNA -- -- -- -- Q8BYK6 754 2.2e-78 YTH domain-containing family protein 3 OS=Mus musculus GN=Ythdf3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1901 Uncharacterized high-glucose-regulated protein Cluster-8309.37907 BF_2 631.00 22.60 1455 189237082 XP_001810630.1 1367 2.9e-148 PREDICTED: WD repeat-containing protein 55 homolog [Tribolium castaneum]>gi|270007253|gb|EFA03701.1| hypothetical protein TcasGA2_TC013806 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IF90 1010 3.0e-108 WD repeat-containing protein 55 homolog OS=Aedes aegypti GN=AAEL006422 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2444 WD40 repeat protein Cluster-8309.37908 BF_2 1397.14 4.30 13876 270013752 EFA10200.1 800 1.5e-81 hypothetical protein TcasGA2_TC012395 [Tribolium castaneum] 642934667 XM_008199538.1 207 5.38737e-101 PREDICTED: Tribolium castaneum nuclear receptor-binding protein homolog (LOC661173), mRNA K08875 NRBP nuclear receptor-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08875 Q297L2 566 8.7e-56 Nuclear receptor-binding protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=Madm PE=3 SV=2 PF00069//PF07714//PF01529//PF00767//PF01365 Protein kinase domain//Protein tyrosine kinase//DHHC palmitoyltransferase//Potyvirus coat protein//RIH domain GO:0006468//GO:0070588//GO:0006816 protein phosphorylation//calcium ion transmembrane transport//calcium ion transport GO:0005524//GO:0005262//GO:0004672//GO:0008270 ATP binding//calcium channel activity//protein kinase activity//zinc ion binding GO:0019028//GO:0016020 viral capsid//membrane KOG1266 Protein kinase Cluster-8309.37909 BF_2 91.74 1.02 4044 332373020 AEE61651.1 619 4.4e-61 unknown [Dendroctonus ponderosae]>gi|478250449|gb|ENN70944.1| hypothetical protein YQE_12346, partial [Dendroctonus ponderosae]>gi|546677327|gb|ERL88184.1| hypothetical protein D910_05572 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37910 BF_2 1656.12 19.28 3881 91078996 XP_974675.1 1185 9.8e-127 PREDICTED: zinc transporter ZIP1 [Tribolium castaneum]>gi|270003679|gb|EFA00127.1| hypothetical protein TcasGA2_TC002943 [Tribolium castaneum] -- -- -- -- -- K14709 SLC39A1_2_3, ZIP1_2_3 solute carrier family 39 (zinc transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14709 P59889 292 1.4e-24 Zinc transporter ZIP1 OS=Danio rerio GN=slc39a1 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085//GO:0044765 metal ion transport//transmembrane transport//single-organism transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG1558 Fe2+/Zn2+ regulated transporter Cluster-8309.37913 BF_2 8161.98 209.36 1918 478257768 ENN77911.1 1426 5.5e-155 hypothetical protein YQE_05588, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BI17 442 2.9e-42 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.37916 BF_2 2374.00 16.92 6156 805796841 XP_003704470.2 983 4.1e-103 PREDICTED: neuronal calcium sensor 2 isoform X1 [Megachile rotundata] 817206217 XM_012423619.1 296 7.98606e-151 PREDICTED: Orussus abietinus neuronal calcium sensor 2 (LOC105698961), mRNA -- -- -- -- P36609 641 7.7e-65 Neuronal calcium sensor 2 OS=Caenorhabditis elegans GN=ncs-2 PE=2 SV=2 PF13202//PF00036//PF12763//PF13499//PF13833//PF10591//PF13405//PF01763 EF hand//EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Herpesvirus UL6 like GO:0007165//GO:0006323 signal transduction//DNA packaging GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.37917 BF_2 2738.83 367.36 599 91092686 XP_971550.1 229 1.1e-16 PREDICTED: ATPase inhibitor mai-2, mitochondrial [Tribolium castaneum]>gi|270014813|gb|EFA11261.1| hypothetical protein TcasGA2_TC010795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8XZB0 169 4.0e-11 ATPase inhibitor mai-2, mitochondrial OS=Caenorhabditis briggsae GN=mai-2 PE=3 SV=1 PF07851//PF04568//PF08702 TMPIT-like protein//Mitochondrial ATPase inhibitor, IATP//Fibrinogen alpha/beta chain family GO:0030168//GO:0032780//GO:0007165//GO:0051258 platelet activation//negative regulation of ATPase activity//signal transduction//protein polymerization GO:0005102//GO:0030674//GO:0042030 receptor binding//protein binding, bridging//ATPase inhibitor activity GO:0005577//GO:0005739//GO:0016021 fibrinogen complex//mitochondrion//integral component of membrane -- -- Cluster-8309.37918 BF_2 1062.11 10.52 4510 91083171 XP_972171.1 2439 4.5e-272 PREDICTED: mRNA-capping enzyme [Tribolium castaneum]>gi|270006979|gb|EFA03427.1| hypothetical protein TcasGA2_TC013414 [Tribolium castaneum] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 O55236 1662 2.3e-183 mRNA-capping enzyme OS=Mus musculus GN=Rngtt PE=1 SV=1 PF00102//PF01331//PF15182//PF03919//PF00782 Protein-tyrosine phosphatase//mRNA capping enzyme, catalytic domain//Otospiralin//mRNA capping enzyme, C-terminal domain//Dual specificity phosphatase, catalytic domain GO:0006370//GO:0035335//GO:0006397//GO:0007605//GO:0006570//GO:0006470 7-methylguanosine mRNA capping//peptidyl-tyrosine dephosphorylation//mRNA processing//sensory perception of sound//tyrosine metabolic process//protein dephosphorylation GO:0004651//GO:0004725//GO:0004484//GO:0008138 polynucleotide 5'-phosphatase activity//protein tyrosine phosphatase activity//mRNA guanylyltransferase activity//protein tyrosine/serine/threonine phosphatase activity GO:0005634 nucleus KOG2386 mRNA capping enzyme, guanylyltransferase (alpha) subunit Cluster-8309.37919 BF_2 2566.36 22.50 5059 546673374 ERL84995.1 488 8.5e-46 hypothetical protein D910_02418 [Dendroctonus ponderosae] -- -- -- -- -- K00669 AANAT arylalkylamine N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00669 Q94521 257 2.1e-20 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.37921 BF_2 375.06 18.91 1117 270002027 EEZ98474.1 452 2.8e-42 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWD0 135 6.6e-07 Gametocyte-specific factor 1-like OS=Mus musculus GN=Gtsf1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4376 Uncharacterized conserved protein Cluster-8309.37922 BF_2 3852.11 40.53 4263 642928729 XP_008199757.1 2652 8.4e-297 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 746860384 XM_011062730.1 215 5.87849e-106 PREDICTED: Acromyrmex echinatior phosphoenolpyruvate carboxykinase [GTP]-like (LOC105149957), transcript variant X4, mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 2332 4.4e-261 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37923 BF_2 958.20 13.26 3311 642910207 XP_008198406.1 2005 6.9e-222 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 245 3.4e-19 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.37925 BF_2 475.20 59.72 620 642938589 XP_008199854.1 397 3.7e-36 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X3 [Tribolium castaneum] 642938588 XM_008201632.1 200 1.7777e-98 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X7, mRNA -- -- -- -- -- -- -- -- PF12424//PF00844 Plasma membrane calcium transporter ATPase C terminal//Geminivirus coat protein/nuclear export factor BR1 family GO:0006816 calcium ion transport GO:0005198//GO:0005388 structural molecule activity//calcium-transporting ATPase activity GO:0016529//GO:0019028 sarcoplasmic reticulum//viral capsid -- -- Cluster-8309.37926 BF_2 290.69 1.81 7010 642938587 XP_008199853.1 4992 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 442614369 NM_001014687.4 380 0 Drosophila melanogaster plasma membrane calcium ATPase (PMCA), transcript variant N, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 P11505 3442 0.0e+00 Plasma membrane calcium-transporting ATPase 1 OS=Rattus norvegicus GN=Atp2b1 PE=2 SV=2 PF00122//PF12424 E1-E2 ATPase//Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0046872//GO:0000166//GO:0005388 metal ion binding//nucleotide binding//calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.37927 BF_2 1009.95 11.43 3982 270008659 EFA05107.1 3005 0.0e+00 hypothetical protein TcasGA2_TC015207 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 P42893 1657 7.7e-183 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF01431//PF01447//PF05649 Peptidase family M13//Thermolysin metallopeptidase, catalytic domain//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.37929 BF_2 46.92 0.41 5066 642927880 XP_008195434.1 2844 0.0e+00 PREDICTED: zinc finger protein 608-like isoform X1 [Tribolium castaneum] 642927883 XM_008197214.1 252 1.89066e-126 PREDICTED: Tribolium castaneum zinc finger protein 608-like (LOC662416), transcript variant X3, mRNA -- -- -- -- O15014 456 1.8e-43 Zinc finger protein 609 OS=Homo sapiens GN=ZNF609 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.37930 BF_2 1574.77 27.62 2672 189236706 XP_974173.2 1504 6.9e-164 PREDICTED: carbonic anhydrase-related protein 10 [Tribolium castaneum] 642920949 XM_969080.3 341 3.32251e-176 PREDICTED: Tribolium castaneum carbonic anhydrase-related protein 10 (LOC663015), mRNA -- -- -- -- Q5R4U0 636 1.3e-64 Carbonic anhydrase-related protein 10 OS=Pongo abelii GN=CA10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0382 Carbonic anhydrase Cluster-8309.37933 BF_2 3442.00 60.43 2670 91094833 XP_971377.1 1765 3.8e-194 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 [Tribolium castaneum]>gi|270006555|gb|EFA03003.1| hypothetical protein TcasGA2_TC010426 [Tribolium castaneum] -- -- -- -- -- K12667 SWP1, RPN2 oligosaccharyltransferase complex subunit delta (ribophorin II) http://www.genome.jp/dbget-bin/www_bget?ko:K12667 Q9GL01 497 1.7e-48 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 OS=Sus scrofa GN=RPN2 PE=2 SV=1 PF05817 Oligosaccharyltransferase subunit Ribophorin II GO:0006487 protein N-linked glycosylation -- -- GO:0016021//GO:0008250 integral component of membrane//oligosaccharyltransferase complex KOG2447 Oligosaccharyltransferase, delta subunit (ribophorin II) Cluster-8309.37935 BF_2 2841.00 63.09 2171 189237461 XP_001807996.1 214 2.2e-14 PREDICTED: tubby-related protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37936 BF_2 80.00 10.98 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37937 BF_2 10.44 0.34 1562 642918280 XP_008191442.1 2126 3.0e-236 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 195430887 XM_002063444.1 277 7.27107e-141 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 Q27HV0 1713 9.7e-190 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Sus scrofa GN=OGT PE=2 SV=1 PF05009//PF13181//PF13414//PF13176//PF13371//PF00515//PF02259//PF13374 Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.37938 BF_2 472.00 15.12 1593 91090280 XP_970932.1 887 1.4e-92 PREDICTED: josephin-1 [Tribolium castaneum]>gi|270013789|gb|EFA10237.1| hypothetical protein TcasGA2_TC012435 [Tribolium castaneum] 665808527 XM_008554369.1 59 1.13726e-19 PREDICTED: Microplitis demolitor josephin-2 (LOC103574822), transcript variant X3, mRNA K15235 JOSD josephin http://www.genome.jp/dbget-bin/www_bget?ko:K15235 Q9W422 543 4.6e-54 Josephin-like protein OS=Drosophila melanogaster GN=CG3781 PE=2 SV=3 PF02099 Josephin -- -- GO:0008242 omega peptidase activity -- -- KOG2934 Uncharacterized conserved protein, contains Josephin domain Cluster-8309.37939 BF_2 4196.00 34.22 5417 270004992 EFA01440.1 863 3.0e-89 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 544 1.2e-53 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF00642//PF13895 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Immunoglobulin domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.37940 BF_2 185.45 0.62 12767 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.62865e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.7e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02383//PF05461//PF13895 SacI homology domain//Apolipoprotein L//Immunoglobulin domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0042578//GO:0008289 protein binding//phosphoric ester hydrolase activity//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.37941 BF_2 2398.98 8.72 11802 642918534 XP_008191512.1 3864 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.20197e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1744 1.9e-192 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF05461//PF13895 Apolipoprotein L//Immunoglobulin domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289 protein binding//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.37943 BF_2 35.43 0.49 3301 642929992 XP_975639.2 556 7.2e-54 PREDICTED: uncharacterized protein LOC664550 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QQM4 209 5.1e-15 Zinc finger protein 474 OS=Bos taurus GN=ZNF474 PE=2 SV=1 PF00098//PF13912//PF13465 Zinc knuckle//C2H2-type zinc finger//Zinc-finger double domain -- -- GO:0008270//GO:0003676//GO:0046872 zinc ion binding//nucleic acid binding//metal ion binding -- -- -- -- Cluster-8309.37945 BF_2 142.35 4.65 1567 642915255 XP_008190545.1 1027 8.3e-109 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 630 3.7e-64 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF13673//PF03494//PF13508//PF05301//PF00583 Acetyltransferase (GNAT) domain//Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Acetyltransferase (GNAT) family GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0008080//GO:0019799 N-acetyltransferase activity//tubulin N-acetyltransferase activity GO:0005874//GO:0045298//GO:0016021 microtubule//tubulin complex//integral component of membrane KOG4601 Uncharacterized conserved protein Cluster-8309.37946 BF_2 748.61 7.19 4643 91081989 XP_968889.1 1935 1.3e-213 PREDICTED: large subunit GTPase 1 homolog [Tribolium castaneum]>gi|270007374|gb|EFA03822.1| hypothetical protein TcasGA2_TC013937 [Tribolium castaneum] -- -- -- -- -- K14539 LSG1 large subunit GTPase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14539 Q9W590 1552 1.3e-170 Large subunit GTPase 1 homolog OS=Drosophila melanogaster GN=Ns3 PE=1 SV=1 PF02421//PF04722//PF04548//PF01926//PF03193 Ferrous iron transport protein B//Ssu72-like protein//AIG1 family//50S ribosome-binding GTPase//Protein of unknown function, DUF258 GO:0006397//GO:0006470//GO:0015684 mRNA processing//protein dephosphorylation//ferrous iron transport GO:0015093//GO:0003924//GO:0005525//GO:0004721 ferrous iron transmembrane transporter activity//GTPase activity//GTP binding//phosphoprotein phosphatase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.37947 BF_2 8299.77 47.86 7541 270003910 EFA00358.1 1564 2.2e-170 hypothetical protein TcasGA2_TC003200 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37948 BF_2 3622.56 77.96 2231 91089745 XP_975162.1 1631 1.1e-178 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 1036 4.4e-111 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family -- -- GO:0005524//GO:0016773//GO:0016772 ATP binding//phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring phosphorus-containing groups GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.37952 BF_2 7.69 0.69 752 549438533 AGX25155.1 326 7.7e-28 aminopeptidase N-like protein, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03461 TRCF domain GO:0006281 DNA repair -- -- -- -- -- -- Cluster-8309.37953 BF_2 252.99 7.54 1690 546680809 ERL91015.1 1480 2.7e-161 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1162 8.2e-126 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.37956 BF_2 4628.69 262.07 1026 817220079 XP_012285695.1 949 6.0e-100 PREDICTED: 60S ribosomal protein L7 [Orussus abietinus] 264667340 GU120406.1 272 2.84375e-138 Chrysomela tremulae ribosomal protein L7 (RpL7) mRNA, complete cds K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 P32100 787 1.5e-82 60S ribosomal protein L7 OS=Drosophila melanogaster GN=RpL7 PE=1 SV=2 PF00336//PF02201 DNA polymerase (viral) C-terminal domain//SWIB/MDM2 domain GO:0051252 regulation of RNA metabolic process GO:0005515//GO:0004523 protein binding//RNA-DNA hybrid ribonuclease activity -- -- KOG3184 60S ribosomal protein L7 Cluster-8309.37958 BF_2 974.12 82.85 779 91091124 XP_969500.1 495 2.0e-47 PREDICTED: calcium-binding protein E63-1 [Tribolium castaneum]>gi|642936333|ref|XP_008198399.1| PREDICTED: calcium-binding protein E63-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48593 423 1.9e-40 Calcium-binding protein E63-1 OS=Drosophila melanogaster GN=Eip63F-1 PE=2 SV=2 PF12763//PF13202//PF13499//PF13833//PF10591//PF00036//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.37959 BF_2 3769.00 39.77 4252 470012399 AGI03912.1 868 6.2e-90 ADP-ribosylation factor 4 [Leptinotarsa decemlineata] 152001115 BC147893.1 106 2.29562e-45 Bos taurus ADP-ribosylation factor-like 4C, mRNA (cDNA clone MGC:152553 IMAGE:8429416), complete cds K07945 ARL4 ADP-ribosylation factor-like protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K07945 P61213 541 2.1e-53 ADP-ribosylation factor-like protein 4A OS=Mus musculus GN=Arl4a PE=2 SV=1 PF00025//PF10717//PF08477//PF01127//PF01926//PF00503//PF04670//PF00071 ADP-ribosylation factor family//Occlusion-derived virus envelope protein ODV-E18//Ras of Complex, Roc, domain of DAPkinase//Succinate dehydrogenase/Fumarate reductase transmembrane subunit//50S ribosome-binding GTPase//G-protein alpha subunit//Gtr1/RagA G protein conserved region//Ras family GO:0007165//GO:0007264//GO:0007186 signal transduction//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0031683//GO:0016627//GO:0005525//GO:0019001//GO:0004871 GTPase activity//G-protein beta/gamma-subunit complex binding//oxidoreductase activity, acting on the CH-CH group of donors//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0019031 viral envelope KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.37960 BF_2 298.00 3.18 4209 102939 522 8.1e-50 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 330 6.1e-29 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.37964 BF_2 540.00 266.95 369 282720995 NP_001164248.1 371 2.3e-33 cytochrome P450 9Z4 [Tribolium castaneum]>gi|270012794|gb|EFA09242.1| cytochrome P450 9Z4 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 247 2.3e-20 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0046872//GO:0016705 heme binding//iron ion binding//oxidoreductase activity//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.37965 BF_2 279.26 2.56 4857 642938005 XP_008199168.1 1238 8.8e-133 PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like isoform X2 [Tribolium castaneum]>gi|270015674|gb|EFA12122.1| hypothetical protein TcasGA2_TC002268 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 P59644 534 1.6e-52 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus GN=Inpp5j PE=2 SV=2 PF06330 Trichodiene synthase (TRI5) GO:0016106//GO:0016114//GO:0046854 sesquiterpenoid biosynthetic process//terpenoid biosynthetic process//phosphatidylinositol phosphorylation GO:0045482 trichodiene synthase activity -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.37966 BF_2 1997.86 71.50 1456 270004078 EFA00526.1 547 3.5e-53 hypothetical protein TcasGA2_TC003391 [Tribolium castaneum] 662204498 XM_008477405.1 35 2.27726e-06 PREDICTED: Diaphorina citri uncharacterized LOC103512635 (LOC103512635), mRNA -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.37967 BF_2 578.84 2.94 8525 642938749 XP_008199873.1 2394 1.4e-266 PREDICTED: cytosolic purine 5'-nucleotidase isoform X3 [Tribolium castaneum] 41393060 NM_201427.1 39 8.12387e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1747 6.0e-193 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 PF09126 Restriction endonuclease NaeI GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0009036 Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.37968 BF_2 216.49 0.82 11315 642925096 XP_008194167.1 5395 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum]>gi|642925098|ref|XP_008194168.1| PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X1 [Tribolium castaneum] 642925099 XM_964960.2 404 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9C102 3369 0.0e+00 Putative glutamate synthase [NADPH] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=glt1 PE=2 SV=1 PF01134//PF00869//PF13241//PF05834//PF00833//PF00287//PF01494//PF07992//PF01210//PF01493//PF00070//PF13443//PF01645//PF04183//PF01266//PF12831//PF01593//PF01070//PF04898//PF00743 Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains//Putative NAD(P)-binding//Lycopene cyclase protein//Ribosomal S17//Sodium / potassium ATPase beta chain//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//GXGXG motif//Pyridine nucleotide-disulphide oxidoreductase//Cro/C1-type HTH DNA-binding domain//Conserved region in glutamate synthase//IucA / IucC family//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//FMN-dependent dehydrogenase//Glutamate synthase central domain//Flavin-binding monooxygenase-like GO:0006537//GO:0008033//GO:0006826//GO:0006412//GO:0006813//GO:0006807//GO:0006779//GO:0055114//GO:0042254//GO:0006814//GO:0046168//GO:0008152//GO:0019354//GO:0019290//GO:0016117 glutamate biosynthetic process//tRNA processing//iron ion transport//translation//potassium ion transport//nitrogen compound metabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//ribosome biogenesis//sodium ion transport//glycerol-3-phosphate catabolic process//metabolic process//siroheme biosynthetic process//siderophore biosynthetic process//carotenoid biosynthetic process GO:0071949//GO:0016638//GO:0043565//GO:0015343//GO:0051287//GO:0050661//GO:0004499//GO:0016705//GO:0050660//GO:0016616//GO:0003735//GO:0016491//GO:0046983//GO:0043115//GO:0015930 FAD binding//oxidoreductase activity, acting on the CH-NH2 group of donors//sequence-specific DNA binding//siderophore transmembrane transporter activity//NAD binding//NADP binding//N,N-dimethylaniline monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//oxidoreductase activity//protein dimerization activity//precorrin-2 dehydrogenase activity//glutamate synthase activity GO:0005622//GO:0005840//GO:0005890 intracellular//ribosome//sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.37969 BF_2 59.24 0.32 8039 642937449 XP_008198840.1 454 1.2e-41 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127//PF00042 Late nodulin protein//Globin GO:0009878 nodule morphogenesis GO:0019825//GO:0046872//GO:0020037 oxygen binding//metal ion binding//heme binding -- -- -- -- Cluster-8309.37970 BF_2 1174.51 13.49 3930 642917757 XP_008191356.1 425 1.3e-38 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 54 1.71016e-16 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.37971 BF_2 443.47 11.52 1897 91076410 XP_969526.1 1383 5.3e-150 PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002563|gb|EEZ99010.1| hypothetical protein TcasGA2_TC004878 [Tribolium castaneum] 731510745 XM_010600440.1 62 2.92133e-21 PREDICTED: Loxodonta africana aldose reductase-related protein 2-like (LOC100673621), mRNA K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P15122 974 5.8e-104 Aldose reductase OS=Oryctolagus cuniculus GN=AKR1B1 PE=2 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.37972 BF_2 2513.94 21.36 5211 546672885 ERL84608.1 2106 2.1e-233 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1003 6.9e-107 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00108//PF08545//PF00107 Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Zinc-binding dehydrogenase GO:0042967//GO:0055114//GO:0008152//GO:0006633 acyl-carrier-protein biosynthetic process//oxidation-reduction process//metabolic process//fatty acid biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.37973 BF_2 30.00 1.41 1180 -- -- -- -- -- 327302703 XM_003235996.1 43 6.55312e-11 Trichophyton rubrum CBS 118892 hypothetical protein (TERG_08771) mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37974 BF_2 75.58 14.05 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37975 BF_2 341.66 6.75 2406 478255178 ENN75407.1 459 9.3e-43 hypothetical protein YQE_07958, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK4 165 4.7e-10 Fatty acid-binding protein 12 OS=Mus musculus GN=Fabp12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.37976 BF_2 534.69 3.40 6870 270009164 EFA05612.1 4289 0.0e+00 hypothetical protein TcasGA2_TC015818 [Tribolium castaneum] 827557043 XM_012694365.1 41 5.05563e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2570 1.8e-288 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF00403//PF05138//PF00122//PF01529 Heavy-metal-associated domain//Phenylacetic acid catabolic protein//E1-E2 ATPase//DHHC palmitoyltransferase GO:0010124//GO:0030001 phenylacetate catabolic process//metal ion transport GO:0046872//GO:0000166//GO:0008270 metal ion binding//nucleotide binding//zinc ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.37977 BF_2 76.35 1.17 3023 91094409 XP_967943.1 1028 1.2e-108 PREDICTED: acyl-CoA Delta(11) desaturase [Tribolium castaneum]>gi|270016351|gb|EFA12797.1| hypothetical protein TcasGA2_TC014819 [Tribolium castaneum]>gi|576636744|gb|AHH30814.1| fatty acid desaturase D7 [Tribolium castaneum] 817052910 XM_012403667.1 71 4.65187e-26 PREDICTED: Athalia rosae acyl-CoA Delta(11) desaturase (LOC105687776), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O44390 636 1.4e-64 Acyl-CoA Delta(11) desaturase OS=Trichoplusia ni GN=D11DS PE=1 SV=2 -- -- GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water GO:0016021 integral component of membrane KOG1600 Fatty acid desaturase Cluster-8309.37978 BF_2 1962.00 79.70 1317 91090326 XP_966482.1 381 5.7e-34 PREDICTED: general transcription factor IIF subunit 1 [Tribolium castaneum]>gi|270013422|gb|EFA09870.1| hypothetical protein TcasGA2_TC012018 [Tribolium castaneum] -- -- -- -- -- K15223 UAF30, SPP27 upstream activation factor subunit UAF30 http://www.genome.jp/dbget-bin/www_bget?ko:K15223 O74503 162 5.8e-10 Upstream activation factor subunit spp27 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=spp27 PE=1 SV=1 PF09726//PF01080//PF04006//PF04147//PF02201 Transmembrane protein//Presenilin//Mpp10 protein//Nop14-like family//SWIB/MDM2 domain GO:0006364 rRNA processing GO:0005515//GO:0003677//GO:0004190 protein binding//DNA binding//aspartic-type endopeptidase activity GO:0032040//GO:0005732//GO:0034457//GO:0016021//GO:0005634 small-subunit processome//small nucleolar ribonucleoprotein complex//Mpp10 complex//integral component of membrane//nucleus KOG1946 RNA polymerase I transcription factor UAF Cluster-8309.37979 BF_2 641.78 19.00 1700 55978158 AAV68692.1 1688 2.0e-185 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q2PQM7 1138 5.0e-123 Chitinase-like protein Idgf4 OS=Glossina morsitans morsitans GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.37980 BF_2 19340.94 193.94 4459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.37981 BF_2 1495.00 84.42 1028 332376591 AEE63435.1 1051 9.0e-112 unknown [Dendroctonus ponderosae]>gi|546685738|gb|ERL95193.1| hypothetical protein D910_12461 [Dendroctonus ponderosae] 704269263 XM_010155242.1 100 1.1723e-42 PREDICTED: Eurypyga helias proteasome (prosome, macropain) subunit, alpha type, 6 (PSMA6), transcript variant X2, mRNA K02730 PSMA6 20S proteasome subunit alpha 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02730 Q2YDE4 919 7.5e-98 Proteasome subunit alpha type-6 OS=Bos taurus GN=PSMA6 PE=1 SV=1 PF00227//PF10584 Proteasome subunit//Proteasome subunit A N-terminal signature GO:0006511//GO:0051603 ubiquitin-dependent protein catabolic process//proteolysis involved in cellular protein catabolic process GO:0004175//GO:0004298 endopeptidase activity//threonine-type endopeptidase activity GO:0005839//GO:0019773 proteasome core complex//proteasome core complex, alpha-subunit complex KOG0182 20S proteasome, regulatory subunit alpha type PSMA6/SCL1 Cluster-8309.37982 BF_2 65.39 0.62 4718 254911125 NP_001157183.1 752 1.9e-76 cactus isoform 1 [Tribolium castaneum] -- -- -- -- -- K09259 K09259 ankyrin only family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09259 Q03017 435 4.6e-41 NF-kappa-B inhibitor cactus OS=Drosophila melanogaster GN=cact PE=1 SV=2 PF03279//PF06858//PF13606//PF00023 Bacterial lipid A biosynthesis acyltransferase//Nucleolar GTP-binding protein 1 (NOG1)//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515//GO:0016740//GO:0005525 protein binding//transferase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.37983 BF_2 8800.08 92.78 4255 642928729 XP_008199757.1 2652 8.4e-297 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 746860384 XM_011062730.1 215 5.86736e-106 PREDICTED: Acromyrmex echinatior phosphoenolpyruvate carboxykinase [GTP]-like (LOC105149957), transcript variant X4, mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 2332 4.4e-261 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37984 BF_2 2917.35 111.16 1385 642928729 XP_008199757.1 951 4.8e-100 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X2 [Tribolium castaneum] 796674999 KP096477.1 103 3.42106e-44 Parapenaeopsis cornuta voucher NTOU-M01863 phosphoenolpyruvate carboxykinase (PEPCK) gene, partial cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 827 4.7e-87 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.37985 BF_2 44.74 0.72 2893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37987 BF_2 1206.43 40.41 1536 642931995 XP_008196812.1 1807 2.9e-199 PREDICTED: splicing factor U2AF 50 kDa subunit [Tribolium castaneum]>gi|270011684|gb|EFA08132.1| hypothetical protein TcasGA2_TC005736 [Tribolium castaneum] 642931994 XM_008198590.1 477 0 PREDICTED: Tribolium castaneum splicing factor U2AF 50 kDa subunit (LOC663317), mRNA K12837 U2AF2 splicing factor U2AF 65 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12837 Q24562 1582 1.5e-174 Splicing factor U2AF 50 kDa subunit OS=Drosophila melanogaster GN=U2af50 PE=1 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0000166//GO:0003723//GO:0003676 nucleotide binding//RNA binding//nucleic acid binding GO:0005634 nucleus KOG0120 Splicing factor U2AF, large subunit (RRM superfamily) Cluster-8309.37988 BF_2 46.00 25.50 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.37989 BF_2 90.83 1.38 3049 642917967 XP_008198963.1 3800 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] 766925232 XM_011496200.1 153 1.22417e-71 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1823 3.3e-202 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF12831//PF00070//PF01494//PF07992//PF01266 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase GO:0006566//GO:0006546//GO:0055114//GO:0006544//GO:0006563 threonine metabolic process//glycine catabolic process//oxidation-reduction process//glycine metabolic process//L-serine metabolic process GO:0004047//GO:0071949//GO:0016491 aminomethyltransferase activity//FAD binding//oxidoreductase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.37990 BF_2 3042.54 20.75 6420 332375334 AEE62808.1 407 2.7e-36 unknown [Dendroctonus ponderosae]>gi|478257466|gb|ENN77622.1| hypothetical protein YQE_05916, partial [Dendroctonus ponderosae]>gi|546679860|gb|ERL90248.1| hypothetical protein D910_07600 [Dendroctonus ponderosae] 254583399 XM_002497223.1 38 2.19725e-07 Zygosaccharomyces rouxii hypothetical protein (ZYRO0F01650g) mRNA, complete cds K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q9V429 369 2.8e-33 Thioredoxin-2 OS=Drosophila melanogaster GN=Trx-2 PE=1 SV=2 PF00085//PF02966 Thioredoxin//Mitosis protein DIM1 GO:0045454//GO:0000398 cell redox homeostasis//mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex KOG0907 Thioredoxin Cluster-8309.37994 BF_2 161.07 1.02 6909 642911280 XP_008199354.1 1960 2.4e-216 PREDICTED: glutamate-gated chloride channel isoform X4 [Tribolium castaneum] 768446852 XM_011567086.1 277 3.27017e-140 PREDICTED: Plutella xylostella glutamate-gated chloride channel-like (LOC105395149), partial mRNA K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1755 5.8e-194 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.37995 BF_2 362.88 11.94 1559 478256455 ENN76640.1 1875 3.9e-207 hypothetical protein YQE_06819, partial [Dendroctonus ponderosae]>gi|546684774|gb|ERL94369.1| hypothetical protein D910_11649, partial [Dendroctonus ponderosae] 242009899 XM_002425675.1 83 5.06699e-33 Pediculus humanus corporis heat shock protein 75 kDa, putative, mRNA K09488 TRAP1, HSP75 TNF receptor-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09488 Q9CQN1 1339 2.3e-146 Heat shock protein 75 kDa, mitochondrial OS=Mus musculus GN=Trap1 PE=1 SV=1 PF00183 Hsp90 protein GO:0006950//GO:0006457 response to stress//protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.37996 BF_2 1110.88 12.18 4103 189241229 XP_971878.2 754 9.9e-77 PREDICTED: DNA primase large subunit [Tribolium castaneum]>gi|270013987|gb|EFA10435.1| hypothetical protein TcasGA2_TC012678 [Tribolium castaneum] 820836808 XM_012491581.1 96 8.02127e-40 PREDICTED: Apis florea multiple coagulation factor deficiency protein 2 homolog (LOC100872590), mRNA K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 P33610 622 8.2e-63 DNA primase large subunit OS=Mus musculus GN=Prim2 PE=1 SV=1 PF09606//PF00036//PF03153//PF03133//PF13202//PF13499//PF13833//PF13405//PF04104 ARC105 or Med15 subunit of Mediator complex non-fungal//EF hand//Transcription factor IIA, alpha/beta subunit//Tubulin-tyrosine ligase family//EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Eukaryotic and archaeal DNA primase, large subunit GO:0006464//GO:0006351//GO:0006357//GO:0006269//GO:0006367 cellular protein modification process//transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//DNA replication, synthesis of RNA primer//transcription initiation from RNA polymerase II promoter GO:0003896//GO:0001104//GO:0005509 DNA primase activity//RNA polymerase II transcription cofactor activity//calcium ion binding GO:0016592//GO:0005657//GO:0005672//GO:0005730 mediator complex//replication fork//transcription factor TFIIA complex//nucleolus KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.37997 BF_2 91.12 1.50 2829 546682240 ERL92201.1 1494 1.1e-162 hypothetical protein D910_09521 [Dendroctonus ponderosae] 195505178 XM_002099356.1 56 9.48237e-18 Drosophila yakuba GE23386 (Dyak\GE23386), partial mRNA K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q9VA73 1209 4.9e-131 Calcium-binding mitochondrial carrier protein Aralar1 OS=Drosophila melanogaster GN=aralar1 PE=2 SV=1 PF13833//PF13405//PF00036//PF13499//PF13202 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.37998 BF_2 7072.59 548.06 827 91079965 XP_969696.1 626 1.4e-62 PREDICTED: 60S ribosomal protein L14 [Tribolium castaneum]>gi|270004603|gb|EFA01051.1| hypothetical protein TcasGA2_TC003967 [Tribolium castaneum] -- -- -- -- -- K02875 RP-L14e, RPL14 large subunit ribosomal protein L14e http://www.genome.jp/dbget-bin/www_bget?ko:K02875 Q95ZE8 422 2.6e-40 60S ribosomal protein L14 OS=Drosophila virilis GN=RpL14 PE=3 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3421 60S ribosomal protein L14 Cluster-8309.37999 BF_2 157.38 0.96 7158 270003134 EEZ99581.1 841 1.4e-86 hypothetical protein TcasGA2_TC001567 [Tribolium castaneum] 642915764 XM_008201849.1 58 1.86834e-18 PREDICTED: Tribolium castaneum zinc finger protein ubi-d4 B-like (LOC655725), mRNA K17770 TOM20 mitochondrial import receptor subunit TOM20 http://www.genome.jp/dbget-bin/www_bget?ko:K17770 A6H7B1 316 4.4e-27 Mitochondrial import receptor subunit TOM20 homolog OS=Bos taurus GN=TOMM20 PE=2 SV=1 PF00684//PF02064 DnaJ central domain//MAS20 protein import receptor GO:0006886//GO:0006605 intracellular protein transport//protein targeting GO:0051082//GO:0031072 unfolded protein binding//heat shock protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG4056 Translocase of outer mitochondrial membrane complex, subunit TOM20 Cluster-8309.38000 BF_2 1051.86 47.37 1216 189238710 XP_969341.2 1642 3.1e-180 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 662207554 XM_008479062.1 49 3.12256e-14 PREDICTED: Diaphorina citri trichohyalin-like (LOC103514197), mRNA -- -- -- -- Q9JM99 200 2.1e-14 Proteoglycan 4 OS=Mus musculus GN=Prg4 PE=1 SV=2 PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0006468//GO:0009069//GO:0016310 signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005096//GO:0004674 GTPase activator activity//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.38002 BF_2 868.00 26.57 1654 189235713 XP_968592.2 1071 6.9e-114 PREDICTED: uncharacterized protein LOC657010 [Tribolium castaneum]>gi|270003390|gb|EEZ99837.1| hypothetical protein TcasGA2_TC002618 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38003 BF_2 35.53 1.04 1714 270001943 EEZ98390.1 619 1.9e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 6.40293e-117 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 8.0e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.38004 BF_2 67.83 0.55 5422 478253683 ENN73984.1 622 2.6e-61 hypothetical protein YQE_09419, partial [Dendroctonus ponderosae]>gi|478266021|gb|ENN82657.1| hypothetical protein YQE_00972, partial [Dendroctonus ponderosae] 617660876 XM_007537263.1 115 2.91201e-50 PREDICTED: Erinaceus europaeus ZFP36 ring finger protein-like 2 (ZFP36L2), mRNA K18753 ZFP36L butyrate response factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18753 P47980 385 3.3e-35 Protein TIS11 OS=Drosophila melanogaster GN=Tis11 PE=2 SV=2 PF00642//PF08352 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Oligopeptide/dipeptide transporter, C-terminal region GO:0015833 peptide transport GO:0046872//GO:0000166//GO:0005524 metal ion binding//nucleotide binding//ATP binding -- -- KOG1677 CCCH-type Zn-finger protein Cluster-8309.38005 BF_2 167.19 5.41 1579 642927514 XP_008195300.1 1575 2.4e-172 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] 645016212 XM_008213163.1 152 2.25696e-71 PREDICTED: Nasonia vitripennis RNA-binding protein fusilli (LOC100120385), transcript variant X2, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 968 2.4e-103 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1365 RNA-binding protein Fusilli, contains RRM domain Cluster-8309.38006 BF_2 442.11 1.34 14125 642930533 XP_008196445.1 4929 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 642930520 XM_008198217.1 971 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X6, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 4185 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.38007 BF_2 440.10 7.88 2623 91082539 XP_973726.1 2209 1.2e-245 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 4.7e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF06905//PF08496//PF11965//PF03357 Fas apoptotic inhibitory molecule (FAIM1)//Peptidase family S49 N-terminal//Domain of unknown function (DUF3479)//Snf7 GO:0007034//GO:0015994//GO:0043066 vacuolar transport//chlorophyll metabolic process//negative regulation of apoptotic process GO:0016851//GO:0004252 magnesium chelatase activity//serine-type endopeptidase activity GO:0005886//GO:0010007 plasma membrane//magnesium chelatase complex -- -- Cluster-8309.38008 BF_2 3893.55 70.39 2601 91082539 XP_973726.1 2209 1.2e-245 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 4.7e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF08496//PF06905//PF11965//PF03357 Peptidase family S49 N-terminal//Fas apoptotic inhibitory molecule (FAIM1)//Domain of unknown function (DUF3479)//Snf7 GO:0043066//GO:0015994//GO:0007034 negative regulation of apoptotic process//chlorophyll metabolic process//vacuolar transport GO:0004252//GO:0016851 serine-type endopeptidase activity//magnesium chelatase activity GO:0010007//GO:0005886 magnesium chelatase complex//plasma membrane -- -- Cluster-8309.38009 BF_2 8.00 41.01 252 642922790 XP_008193326.1 279 7.2e-23 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38010 BF_2 884.10 5.62 6865 91082533 XP_973629.1 1806 1.7e-198 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X1 [Tribolium castaneum]>gi|270007557|gb|EFA04005.1| hypothetical protein TcasGA2_TC014154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 878 2.8e-92 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.38012 BF_2 463.68 5.57 3768 91093228 XP_967462.1 705 4.4e-71 PREDICTED: phosphopantothenoylcysteine decarboxylase [Tribolium castaneum]>gi|270016594|gb|EFA13040.1| hypothetical protein TcasGA2_TC010571 [Tribolium castaneum] -- -- -- -- -- K01598 PPCDC, coaC phosphopantothenoylcysteine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01598 Q8BZB2 574 2.8e-57 Phosphopantothenoylcysteine decarboxylase OS=Mus musculus GN=Ppcdc PE=2 SV=1 PF02569//PF02297//PF05676//PF02441 Pantoate-beta-alanine ligase//Cytochrome oxidase c subunit VIb//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Flavoprotein GO:0008152//GO:0006744//GO:0015940//GO:0006120//GO:0006123//GO:0019482//GO:0015992//GO:0006814//GO:0006118 metabolic process//ubiquinone biosynthetic process//pantothenate biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//mitochondrial electron transport, cytochrome c to oxygen//beta-alanine metabolic process//proton transport//sodium ion transport//obsolete electron transport GO:0003954//GO:0003824//GO:0004129//GO:0004592//GO:0008137 NADH dehydrogenase activity//catalytic activity//cytochrome-c oxidase activity//pantoate-beta-alanine ligase activity//NADH dehydrogenase (ubiquinone) activity GO:0045277//GO:0005739 respiratory chain complex IV//mitochondrion KOG0672 Halotolerance protein HAL3 (contains flavoprotein domain) Cluster-8309.38013 BF_2 1472.00 18.96 3535 270005727 EFA02175.1 1798 7.4e-198 hypothetical protein TcasGA2_TC007831 [Tribolium castaneum] -- -- -- -- -- K03211 ETV6_7, yan ETS translocation variant 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K03211 Q01842 523 2.1e-51 Ets DNA-binding protein pokkuri OS=Drosophila melanogaster GN=aop PE=1 SV=2 PF00178//PF02198 Ets-domain//Sterile alpha motif (SAM)/Pointed domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.38014 BF_2 3189.38 185.35 1007 91081323 XP_970047.1 1063 3.6e-113 PREDICTED: uncharacterized oxidoreductase C115.03 [Tribolium castaneum]>gi|270005200|gb|EFA01648.1| hypothetical protein TcasGA2_TC007219 [Tribolium castaneum] -- -- -- -- -- K00010 iolG myo-inositol 2-dehydrogenase / D-chiro-inositol 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00010 O05389 462 7.2e-45 Uncharacterized oxidoreductase YrbE OS=Bacillus subtilis (strain 168) GN=yrbE PE=3 SV=2 PF01408//PF02894 Oxidoreductase family, NAD-binding Rossmann fold//Oxidoreductase family, C-terminal alpha/beta domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.38015 BF_2 209.85 3.78 2610 189241581 XP_969604.2 2441 1.5e-272 PREDICTED: phosphoinositide 3-kinase adapter protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.4e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0016020//GO:0005801 membrane//cis-Golgi network -- -- Cluster-8309.38016 BF_2 1896.37 9.84 8349 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.32184e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF03554//PF05007//PF00089//PF10440//PF00874//PF05384//PF01133 UL73 viral envelope glycoprotein//Mannosyltransferase (PIG-M)//Trypsin//Ubiquitin-binding WIYLD domain//PRD domain//Sensor protein DegS//Enhancer of rudimentary GO:0007049//GO:0006554//GO:0006355//GO:0006508//GO:0006506//GO:0006479//GO:0006221//GO:0007165//GO:0045747 cell cycle//lysine catabolic process//regulation of transcription, DNA-templated//proteolysis//GPI anchor biosynthetic process//protein methylation//pyrimidine nucleotide biosynthetic process//signal transduction//positive regulation of Notch signaling pathway GO:0004252//GO:0016301//GO:0016758//GO:0018024 serine-type endopeptidase activity//kinase activity//transferase activity, transferring hexosyl groups//histone-lysine N-methyltransferase activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.38017 BF_2 324.51 5.94 2573 642910330 XP_970349.3 1091 5.2e-116 PREDICTED: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGE0 671 1.1e-68 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Xenopus tropicalis GN=ogfod3 PE=2 SV=1 PF13640 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.38018 BF_2 3815.73 108.08 1764 91091830 XP_967237.1 891 5.5e-93 PREDICTED: leucine-rich repeat protein soc-2 isoform X1 [Tribolium castaneum] 642937372 XM_962144.2 207 6.73504e-102 PREDICTED: Tribolium castaneum death-associated small cytoplasmic leucine-rich protein SCLP (LOC655583), transcript variant X1, mRNA -- -- -- -- Q8CI70 239 9.1e-19 Leucine-rich repeat-containing protein 20 OS=Mus musculus GN=Lrrc20 PE=2 SV=1 PF02052//PF13855//PF00560 Gallidermin//Leucine rich repeat//Leucine Rich Repeat GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.38019 BF_2 1854.41 12.26 6616 546675258 ERL86494.1 972 8.4e-102 hypothetical protein D910_03898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P70478 235 1.0e-17 Adenomatous polyposis coli protein OS=Rattus norvegicus GN=Apc PE=1 SV=1 PF05924//PF04072//PF05923//PF05972 SAMP Motif//Leucine carboxyl methyltransferase//APC cysteine-rich region//APC 15 residue motif GO:0016055//GO:0032259 Wnt signaling pathway//methylation GO:0008168//GO:0008013 methyltransferase activity//beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.3802 BF_2 2.00 0.32 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09553 Eco47II restriction endonuclease GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0009036//GO:0003677 Type II site-specific deoxyribonuclease activity//DNA binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.38022 BF_2 959.06 14.02 3149 642917834 XP_008191303.1 1003 1.0e-105 PREDICTED: serine/threonine-protein kinase MARK2 isoform X2 [Tribolium castaneum] 602660707 XM_007435954.1 79 1.73139e-30 PREDICTED: Python bivittatus MAP/microtubule affinity-regulating kinase 1 (MARK1), transcript variant X5, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 Q9P0L2 517 9.5e-51 Serine/threonine-protein kinase MARK1 OS=Homo sapiens GN=MARK1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0586 Serine/threonine protein kinase Cluster-8309.38023 BF_2 21.24 0.52 2004 642916360 XP_008190988.1 350 3.4e-30 PREDICTED: protein disulfide-isomerase [Tribolium castaneum]>gi|270004199|gb|EFA00647.1| hypothetical protein TcasGA2_TC003523 [Tribolium castaneum] 687910403 LK979553.1 48 1.87242e-13 Thelazia callipaeda genome assembly T_callipaeda_Ticino ,scaffold TCLT_scaffold0000014 K09580 PDIA1, P4HB protein disulfide-isomerase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K09580 P54399 294 4.3e-25 Protein disulfide-isomerase OS=Drosophila melanogaster GN=Pdi PE=2 SV=1 PF00462//PF00578//PF00085//PF00854 Glutaredoxin//AhpC/TSA family//Thioredoxin//POT family GO:0006118//GO:0045454//GO:0055114//GO:0006810//GO:0006662 obsolete electron transport//cell redox homeostasis//oxidation-reduction process//transport//glycerol ether metabolic process GO:0015035//GO:0016209//GO:0009055//GO:0016491//GO:0016853//GO:0005215 protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity//oxidoreductase activity//isomerase activity//transporter activity GO:0016020//GO:0005783 membrane//endoplasmic reticulum KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.38024 BF_2 300.00 24.23 805 91093539 XP_966844.1 649 2.9e-65 PREDICTED: short coiled-coil protein homolog [Tribolium castaneum]>gi|270015586|gb|EFA12034.1| hypothetical protein TcasGA2_TC001451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8NJZ7 271 8.1e-23 Short coiled-coil protein homolog OS=Brugia malayi GN=Bm1_04115 PE=3 SV=1 PF06005//PF02183//PF00170//PF09728//PF08650//PF06156//PF04977 Protein of unknown function (DUF904)//Homeobox associated leucine zipper//bZIP transcription factor//Myosin-like coiled-coil protein//DASH complex subunit Dad4//Protein of unknown function (DUF972)//Septum formation initiator GO:0006355//GO:0008608//GO:0006260//GO:0007049//GO:0043093//GO:0000917 regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore//DNA replication//cell cycle//FtsZ-dependent cytokinesis//barrier septum assembly GO:0019905//GO:0043565//GO:0003700 syntaxin binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0072686//GO:0005667//GO:0042729//GO:0005737 mitotic spindle//transcription factor complex//DASH complex//cytoplasm KOG3650 Predicted coiled-coil protein Cluster-8309.38025 BF_2 376.41 2.20 7429 642938587 XP_008199853.1 4992 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X2 [Tribolium castaneum] 442614369 NM_001014687.4 380 0 Drosophila melanogaster plasma membrane calcium ATPase (PMCA), transcript variant N, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 P11505 3442 0.0e+00 Plasma membrane calcium-transporting ATPase 1 OS=Rattus norvegicus GN=Atp2b1 PE=2 SV=2 PF00122//PF12424 E1-E2 ATPase//Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0046872//GO:0000166//GO:0005388 metal ion binding//nucleotide binding//calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.38026 BF_2 6391.94 40.80 6840 642938591 XP_008199855.1 4992 0.0e+00 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X4 [Tribolium castaneum] 642938592 XM_008201634.1 1323 0 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X9, mRNA K05850 ATP2B Ca2+ transporting ATPase, plasma membrane http://www.genome.jp/dbget-bin/www_bget?ko:K05850 P11505 3442 0.0e+00 Plasma membrane calcium-transporting ATPase 1 OS=Rattus norvegicus GN=Atp2b1 PE=2 SV=2 PF12424//PF00122 Plasma membrane calcium transporter ATPase C terminal//E1-E2 ATPase GO:0006816 calcium ion transport GO:0046872//GO:0005388//GO:0000166 metal ion binding//calcium-transporting ATPase activity//nucleotide binding GO:0016529 sarcoplasmic reticulum KOG0204 Calcium transporting ATPase Cluster-8309.38027 BF_2 21.02 1.21 1014 91084843 XP_966905.1 630 5.8e-63 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 373 1.5e-34 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.38028 BF_2 968.14 16.86 2689 642922869 XP_008200431.1 3132 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] 768439826 XM_011563263.1 40 7.06211e-09 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1512 3.4e-166 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF00664//PF13304 ABC transporter//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.38029 BF_2 50.31 0.54 4193 642922869 XP_008200431.1 2781 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] 768439826 XM_011563263.1 40 1.10657e-08 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1410 3.6e-154 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13304//PF00664//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//ABC transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.3803 BF_2 6.00 0.73 631 91078218 XP_969246.1 316 9.3e-27 PREDICTED: ubiquitin-like protein 5 [Tribolium castaneum]>gi|270002984|gb|EEZ99431.1| hypothetical protein TcasGA2_TC030562 [Tribolium castaneum] 815820526 XM_012376058.1 73 7.19193e-28 PREDICTED: Linepithema humile ubiquitin-like protein 5 (LOC105677441), mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q3T0Z3 280 5.7e-24 Ubiquitin-like protein 5 OS=Bos taurus GN=UBL5 PE=3 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-8309.38030 BF_2 178.37 4.03 2140 642939251 XP_008194779.1 688 2.3e-69 PREDICTED: UPF0602 protein C4orf47-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7E2U8 309 8.4e-27 UPF0602 protein C4orf47 OS=Homo sapiens GN=C4orf47 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38031 BF_2 246.00 18.25 851 91080319 XP_974435.1 615 2.7e-61 PREDICTED: 39S ribosomal protein L21, mitochondrial [Tribolium castaneum]>gi|270005606|gb|EFA02054.1| hypothetical protein TcasGA2_TC007683 [Tribolium castaneum] -- -- -- -- -- K02888 RP-L21, MRPL21, rplU large subunit ribosomal protein L21 http://www.genome.jp/dbget-bin/www_bget?ko:K02888 Q2TBS2 274 3.8e-23 39S ribosomal protein L21, mitochondrial OS=Bos taurus GN=MRPL21 PE=1 SV=1 PF00829 Ribosomal prokaryotic L21 protein -- -- -- -- GO:0005622//GO:0005840 intracellular//ribosome KOG1686 Mitochondrial/chloroplast ribosomal L21 protein Cluster-8309.38032 BF_2 92.10 1.01 4118 642912998 XP_008201345.1 801 3.5e-82 PREDICTED: synaptic vesicle glycoprotein 2C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q9JIS5 276 1.1e-22 Synaptic vesicle glycoprotein 2A OS=Mus musculus GN=Sv2a PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38033 BF_2 492.00 63.16 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38035 BF_2 146.94 1.43 4600 642922737 XP_008193304.1 1814 1.4e-199 PREDICTED: protein RRP5 homolog [Tribolium castaneum] -- -- -- -- -- K14792 RRP5, PDCD11 rRNA biogenesis protein RRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K14792 Q14690 642 4.4e-65 Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3 PF05843//PF00575//PF13374 Suppressor of forked protein (Suf)//S1 RNA binding domain//Tetratricopeptide repeat GO:0006397 mRNA processing GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus KOG1070 rRNA processing protein Rrp5 Cluster-8309.38036 BF_2 529.94 4.99 4728 332374310 AEE62296.1 1023 7.3e-108 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 474 1.4e-45 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF01353 Green fluorescent protein GO:0008218 bioluminescence -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.38039 BF_2 55.33 0.66 3815 642933627 XP_008197501.1 1240 4.1e-133 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Tribolium castaneum] 676386870 XM_009038466.1 51 7.72161e-15 Aureococcus anophagefferens hypothetical protein partial mRNA K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60484 772 3.1e-80 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens GN=PTEN PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0004721//GO:0008138 protein tyrosine phosphatase activity//phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases Cluster-8309.38040 BF_2 1255.84 14.13 4005 642926721 XP_008194985.1 1671 4.5e-183 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642926723|ref|XP_008194986.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 552 1.1e-54 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.38042 BF_2 346.44 7.06 2339 642928668 XP_008199729.1 1726 1.1e-189 PREDICTED: protein daughterless isoform X6 [Tribolium castaneum] 642928667 XM_008201507.1 357 0 PREDICTED: Tribolium castaneum protein daughterless (LOC662057), transcript variant X6, mRNA K15603 TCF4_12 transcription factor 4/12 http://www.genome.jp/dbget-bin/www_bget?ko:K15603 P11420 592 1.4e-59 Protein daughterless OS=Drosophila melanogaster GN=da PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG3910 Helix loop helix transcription factor Cluster-8309.38043 BF_2 107.05 1.78 2799 270003153 EEZ99600.1 2599 7.7e-291 hypothetical protein TcasGA2_TC002116 [Tribolium castaneum] 751219340 XM_011164448.1 192 2.34554e-93 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q11002 2129 1.0e-237 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF13202//PF00648//PF13499//PF13405//PF00036//PF13833 EF hand//Calpain family cysteine protease//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair GO:0006508 proteolysis GO:0005509//GO:0004198 calcium ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.38045 BF_2 432.81 4.65 4181 332373348 AEE61815.1 1558 5.9e-170 unknown [Dendroctonus ponderosae] 769840408 XM_011633076.1 188 5.8881e-91 PREDICTED: Pogonomyrmex barbatus probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (LOC105423352), transcript variant X2, mRNA K00161 PDHA, pdhA pyruvate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00161 P26268 1220 3.8e-132 Pyruvate dehydrogenase E1 component subunit alpha type II, mitochondrial (Fragment) OS=Ascaris suum PE=2 SV=1 PF13292//PF00676//PF02775//PF09029 1-deoxy-D-xylulose-5-phosphate synthase//Dehydrogenase E1 component//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//5-aminolevulinate synthase presequence GO:0042967//GO:0016114//GO:0006563//GO:0006694//GO:0006778//GO:0006566//GO:0008152//GO:0006544//GO:0006783 acyl-carrier-protein biosynthetic process//terpenoid biosynthetic process//L-serine metabolic process//steroid biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process//metabolic process//glycine metabolic process//heme biosynthetic process GO:0008661//GO:0003870//GO:0030170//GO:0003824//GO:0016624//GO:0030976 1-deoxy-D-xylulose-5-phosphate synthase activity//5-aminolevulinate synthase activity//pyridoxal phosphate binding//catalytic activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//thiamine pyrophosphate binding GO:0005759 mitochondrial matrix KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.38046 BF_2 158.14 3.61 2121 642933063 XP_008197247.1 1689 1.9e-185 PREDICTED: rab GTPase-binding effector protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35551 370 7.1e-34 Rab GTPase-binding effector protein 1 OS=Mus musculus GN=Rabep1 PE=1 SV=2 PF03528 Rabaptin GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005096//GO:0008083 GTPase activator activity//growth factor activity -- -- KOG0993 Rab5 GTPase effector Rabaptin-5 Cluster-8309.38047 BF_2 7797.82 217.06 1790 642922291 XP_008193096.1 1223 1.8e-131 PREDICTED: uncharacterized protein LOC661530 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 189 5.8e-13 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF02270//PF00441//PF13180//PF00595 Transcription initiation factor IIF, beta subunit//Acyl-CoA dehydrogenase, C-terminal domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006367//GO:0055114//GO:0006366 transcription initiation from RNA polymerase II promoter//oxidation-reduction process//transcription from RNA polymerase II promoter GO:0016627//GO:0005515 oxidoreductase activity, acting on the CH-CH group of donors//protein binding GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.38048 BF_2 3886.91 87.38 2148 546682240 ERL92201.1 2808 0.0e+00 hypothetical protein D910_09521 [Dendroctonus ponderosae] 195505178 XM_002099356.1 56 7.17599e-18 Drosophila yakuba GE23386 (Dyak\GE23386), partial mRNA K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q9VA73 2280 2.4e-255 Calcium-binding mitochondrial carrier protein Aralar1 OS=Drosophila melanogaster GN=aralar1 PE=2 SV=1 PF13202//PF13405//PF13833//PF00036//PF13499 EF hand//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.38050 BF_2 5176.34 30.37 7417 642930349 XP_008196359.1 6991 0.0e+00 PREDICTED: protein 4.1 homolog isoform X1 [Tribolium castaneum]>gi|642930351|ref|XP_008196360.1| PREDICTED: protein 4.1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 1372 1.6e-149 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 PF16954//PF05902 Haem-transporter, endosomal/lysosomal, haem-responsive gene//4.1 protein C-terminal domain (CTD) GO:0015886 heme transport GO:0015232//GO:0003779//GO:0005198 heme transporter activity//actin binding//structural molecule activity GO:0005856 cytoskeleton KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.38052 BF_2 10.00 9.75 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02701 Dof domain, zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.38053 BF_2 715.06 28.30 1344 642915369 XP_008190587.1 981 1.5e-103 PREDICTED: facilitated trehalose transporter Tret1-like isoform X1 [Tribolium castaneum]>gi|642915372|ref|XP_008190589.1| PREDICTED: facilitated trehalose transporter Tret1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY2 356 1.9e-32 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38055 BF_2 281.78 9.15 1576 91090908 XP_973835.1 1721 2.8e-189 PREDICTED: 4-hydroxyphenylpyruvate dioxygenase [Tribolium castaneum]>gi|270014008|gb|EFA10456.1| hypothetical protein TcasGA2_TC012702 [Tribolium castaneum] -- -- -- -- -- K00457 HPD, hppD 4-hydroxyphenylpyruvate dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00457 Q5EA20 1331 1.9e-145 4-hydroxyphenylpyruvate dioxygenase OS=Bos taurus GN=HPD PE=2 SV=3 -- -- GO:0006558//GO:0009072//GO:0006570//GO:0055114 L-phenylalanine metabolic process//aromatic amino acid family metabolic process//tyrosine metabolic process//oxidation-reduction process GO:0046872//GO:0003868 metal ion binding//4-hydroxyphenylpyruvate dioxygenase activity -- -- KOG0638 4-hydroxyphenylpyruvate dioxygenase Cluster-8309.38057 BF_2 188.84 2.64 3277 642912272 XP_008200632.1 796 1.1e-81 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95M17 353 1.0e-31 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0004553 serine-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2806 Chitinase Cluster-8309.38058 BF_2 449.75 8.53 2492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05309 TraE protein GO:0000746 conjugation -- -- -- -- -- -- Cluster-8309.38059 BF_2 966.50 18.75 2443 642910560 XP_008200266.1 2041 3.4e-226 PREDICTED: beta-arrestin-1 isoform X1 [Tribolium castaneum]>gi|270015096|gb|EFA11544.1| kurtz [Tribolium castaneum] 642910565 XM_967463.3 581 0 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 Q4R562 1301 9.0e-142 Beta-arrestin-1 OS=Macaca fascicularis GN=ARRB1 PE=2 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.38060 BF_2 71.53 0.84 3833 270001355 EEZ97802.1 3718 0.0e+00 hypothetical protein TcasGA2_TC000164 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UI26 2292 1.7e-256 Importin-11 OS=Homo sapiens GN=IPO11 PE=1 SV=1 PF02985//PF03810 HEAT repeat//Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0005515//GO:0008536 protein binding//Ran GTPase binding -- -- KOG1993 Nuclear transport receptor KAP120 (importin beta superfamily) Cluster-8309.38061 BF_2 355.88 3.30 4805 189240719 XP_974316.2 3699 0.0e+00 PREDICTED: TBC1 domain family member 9, partial [Tribolium castaneum] 640785773 XM_008050426.1 160 2.48881e-75 PREDICTED: Tarsius syrichta TBC1 domain family, member 9B (with GRAM domain) (TBC1D9B), transcript variant X2, mRNA -- -- -- -- Q6ZT07 2395 2.5e-268 TBC1 domain family member 9 OS=Homo sapiens GN=TBC1D9 PE=2 SV=2 PF13202//PF10637//PF13499//PF00036//PF13833//PF13405 EF hand//Oxoglutarate and iron-dependent oxygenase degradation C-term//EF-hand domain pair//EF hand//EF-hand domain pair//EF-hand domain GO:0055114 oxidation-reduction process GO:0005509//GO:0031418//GO:0016706//GO:0005506 calcium ion binding//L-ascorbic acid binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron ion binding -- -- KOG4347 GTPase-activating protein VRP Cluster-8309.38063 BF_2 34.39 1.02 1695 642925558 XP_008194598.1 1139 9.3e-122 PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925560|ref|XP_008194599.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925562|ref|XP_008194600.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|270008677|gb|EFA05125.1| hypothetical protein TcasGA2_TC015240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6Q4G4 334 8.5e-30 Angiotensin-converting enzyme OS=Theromyzon tessulatum GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.38066 BF_2 10.00 1.41 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38069 BF_2 1545.77 8.10 8266 91079889 XP_968047.1 4173 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 7.1333e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 2.5e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF00443//PF00240//PF14560 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin family//Ubiquitin-like domain GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.38071 BF_2 3185.66 75.64 2049 91087085 XP_974959.1 1262 6.1e-136 PREDICTED: phytepsin [Tribolium castaneum]>gi|270010541|gb|EFA06989.1| hypothetical protein TcasGA2_TC009950 [Tribolium castaneum] -- -- -- -- -- K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 610 1.0e-61 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF00026//PF01186 Eukaryotic aspartyl protease//Lysyl oxidase GO:0006508//GO:0055114 proteolysis//oxidation-reduction process GO:0005507//GO:0004190//GO:0016641 copper ion binding//aspartic-type endopeptidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor -- -- KOG1339 Aspartyl protease Cluster-8309.38073 BF_2 343.43 2.83 5371 332374566 AEE62424.1 835 5.2e-86 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 404 2.0e-37 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01258//PF01853//PF00412 Prokaryotic dksA/traR C4-type zinc finger//MOZ/SAS family//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.38074 BF_2 172.52 1.74 4444 91091728 XP_967315.1 1628 4.8e-178 PREDICTED: argininosuccinate synthase [Tribolium castaneum]>gi|270001069|gb|EEZ97516.1| hypothetical protein TcasGA2_TC011361 [Tribolium castaneum] 78496741 CP000153.1 36 1.96348e-06 Sulfurimonas denitrificans DSM 1251, complete genome K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q0IFL5 1380 1.1e-150 Argininosuccinate synthase OS=Aedes aegypti GN=AAEL004701 PE=3 SV=1 PF00498//PF00764 FHA domain//Arginosuccinate synthase GO:0006526//GO:0006522//GO:0006531//GO:0006560 arginine biosynthetic process//alanine metabolic process//aspartate metabolic process//proline metabolic process GO:0005524//GO:0004055//GO:0005515 ATP binding//argininosuccinate synthase activity//protein binding -- -- KOG1706 Argininosuccinate synthase Cluster-8309.38080 BF_2 39.79 1.54 1370 741829289 AJA91071.1 766 1.3e-78 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 483 3.6e-47 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF08127//PF00067 Peptidase family C1 propeptide//Cytochrome P450 GO:0050790//GO:0055114//GO:0006508 regulation of catalytic activity//oxidation-reduction process//proteolysis GO:0020037//GO:0004197//GO:0005506//GO:0016705 heme binding//cysteine-type endopeptidase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.38081 BF_2 1099.57 8.76 5541 189242442 XP_001807060.1 1926 1.7e-212 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- K19599 DOME cytokine receptor domeless http://www.genome.jp/dbget-bin/www_bget?ko:K19599 Q9VWE0 423 1.3e-39 Cytokine receptor OS=Drosophila melanogaster GN=dome PE=1 SV=1 PF16794//PF00041 Fibronectin-III type domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38083 BF_2 158.48 0.74 9254 642919915 XP_008192123.1 1677 2.1e-183 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] 462448440 APGK01008686.1 56 3.12823e-17 Dendroctonus ponderosae Seq01008694, whole genome shotgun sequence -- -- -- -- Q7Z6G8 754 9.2e-78 Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Homo sapiens GN=ANKS1B PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38085 BF_2 4038.26 48.42 3776 642914766 XP_008190343.1 639 2.0e-63 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 329 7.2e-29 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38087 BF_2 49.10 0.85 2699 55978158 AAV68692.1 1452 7.5e-158 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q2PQM7 931 8.0e-99 Chitinase-like protein Idgf4 OS=Glossina morsitans morsitans GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.38089 BF_2 19.05 0.41 2253 55978158 AAV68692.1 368 3.1e-32 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q9GV28 210 2.7e-15 Chitinase-like protein EN03 OS=Bombyx mori GN=EN03 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38090 BF_2 110.10 1.14 4313 546676660 ERL87624.1 1073 1.1e-113 hypothetical protein D910_05015 [Dendroctonus ponderosae] -- -- -- -- -- K05642 ABCA2 ATP-binding cassette, subfamily A (ABC1), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05642 P78363 618 2.5e-62 Retinal-specific ATP-binding cassette transporter OS=Homo sapiens GN=ABCA4 PE=1 SV=3 PF01312//PF01225//PF06414//PF13304//PF00005//PF04310//PF03193 FlhB HrpN YscU SpaS Family//Mur ligase family, catalytic domain//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//MukB N-terminal//Protein of unknown function, DUF258 GO:0007059//GO:0009058//GO:0030261//GO:0009306 chromosome segregation//biosynthetic process//chromosome condensation//protein secretion GO:0016887//GO:0016301//GO:0005525//GO:0003677//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//DNA binding//ATP binding//GTPase activity GO:0016020//GO:0009295 membrane//nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.38091 BF_2 2533.63 43.10 2746 91095131 XP_971500.1 2329 1.5e-259 PREDICTED: transforming growth factor-beta-induced protein ig-h3 [Tribolium castaneum]>gi|270015611|gb|EFA12059.1| hypothetical protein TcasGA2_TC012903 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15063 555 3.2e-55 Periostin OS=Homo sapiens GN=POSTN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.38092 BF_2 23.05 2.53 669 270009761 EFA06209.1 641 2.0e-64 hypothetical protein TcasGA2_TC009058 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38093 BF_2 1226.01 14.48 3828 91083579 XP_968212.1 2350 7.9e-262 PREDICTED: lysine--tRNA ligase isoform X2 [Tribolium castaneum]>gi|270007824|gb|EFA04272.1| hypothetical protein TcasGA2_TC014562 [Tribolium castaneum] 157106532 XM_001649316.1 207 1.47665e-101 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1951 6.0e-217 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF00152//PF17121//PF01409//PF01336 tRNA synthetases class II (D, K and N)//Zinc finger, C3HC4 type (RING finger)//tRNA synthetases class II core domain (F)//OB-fold nucleic acid binding domain GO:0043039//GO:0006418//GO:0009085//GO:0006430 tRNA aminoacylation//tRNA aminoacylation for protein translation//lysine biosynthetic process//lysyl-tRNA aminoacylation GO:0004812//GO:0008270//GO:0000166//GO:0003676//GO:0005515//GO:0000049//GO:0004824//GO:0005524 aminoacyl-tRNA ligase activity//zinc ion binding//nucleotide binding//nucleic acid binding//protein binding//tRNA binding//lysine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.38094 BF_2 1520.00 14.54 4661 642923453 XP_008193751.1 4355 0.0e+00 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1597 8.2e-176 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF02460//PF00400 Patched family//WD domain, G-beta repeat GO:0007165 signal transduction GO:0008158//GO:0005515 hedgehog receptor activity//protein binding GO:0016020 membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.38096 BF_2 103.58 2.78 1847 270001212 EEZ97659.1 2155 1.6e-239 hypothetical protein TcasGA2_TC016203 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1780 2.0e-197 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF00156 Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process -- -- -- -- KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.38097 BF_2 1802.00 33.90 2511 642928704 XP_008199746.1 2413 2.6e-269 PREDICTED: microtubule-actin cross-linking factor 1 isoform X9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UPN3 770 3.5e-80 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 OS=Homo sapiens GN=MACF1 PE=1 SV=4 PF13499//PF13833//PF00036//PF13405//PF02187//PF00435 EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain//Growth-Arrest-Specific Protein 2 Domain//Spectrin repeat GO:0007050 cell cycle arrest GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.38099 BF_2 30.58 2.05 911 91090278 XP_970876.1 404 8.4e-37 PREDICTED: cell division control protein 42 homolog [Tribolium castaneum]>gi|270014293|gb|EFA10741.1| hypothetical protein TcasGA2_TC012434 [Tribolium castaneum] -- -- -- -- -- K07866 RHOV, WRCH2 Ras homolog gene family, member V http://www.genome.jp/dbget-bin/www_bget?ko:K07866 Q17QI8 254 8.6e-21 Rho-related GTP-binding protein RhoV OS=Bos taurus GN=Rhov PE=2 SV=1 PF00071 Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0016020//GO:0005622 membrane//intracellular KOG0393 Ras-related small GTPase, Rho type Cluster-8309.38100 BF_2 254.24 2.86 4011 91077534 XP_967040.1 750 2.8e-76 PREDICTED: myophilin [Tribolium castaneum]>gi|270001583|gb|EEZ98030.1| hypothetical protein TcasGA2_TC000431 [Tribolium castaneum] 768423547 XM_011554383.1 76 1.0286e-28 PREDICTED: Plutella xylostella muscle-specific protein 20 (LOC105384189), mRNA -- -- -- -- P14318 388 1.1e-35 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 PF00307 Calponin homology (CH) domain GO:0031032 actomyosin structure organization GO:0003779//GO:0005515 actin binding//protein binding -- -- KOG2046 Calponin Cluster-8309.38102 BF_2 112.25 0.69 7095 642920612 XP_008192488.1 1042 6.9e-110 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38103 BF_2 1412.50 25.10 2641 91080431 XP_968599.1 460 7.8e-43 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38104 BF_2 7.00 0.99 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07533 BRK domain -- -- GO:0016817//GO:0005515 hydrolase activity, acting on acid anhydrides//protein binding -- -- -- -- Cluster-8309.38113 BF_2 1480.24 4.35 14512 189233641 XP_001814986.1 2409 4.3e-268 PREDICTED: nicotinate phosphoribosyltransferase isoform X1 [Tribolium castaneum] 242018850 XM_002429839.1 113 1.01205e-48 Pediculus humanus corporis nicotinate phosphoribosyltransferase, putative, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 2054 2.6e-228 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 PF01213//PF16622//PF07776//PF13465//PF00096//PF08603//PF02749 Adenylate cyclase associated (CAP) N terminal//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//Adenylate cyclase associated (CAP) C terminal//Quinolinate phosphoribosyl transferase, N-terminal domain GO:0007010 cytoskeleton organization GO:0003779//GO:0046872//GO:0016763//GO:0008270 actin binding//metal ion binding//transferase activity, transferring pentosyl groups//zinc ion binding GO:0005634 nucleus KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.38114 BF_2 625.84 5.25 5274 91080669 XP_975087.1 970 1.1e-101 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 746866518 XM_011066023.1 149 3.5612e-69 PREDICTED: Acromyrmex echinatior vesicle-trafficking protein SEC22b (LOC105152004), transcript variant X3, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 719 6.0e-74 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.38116 BF_2 668.83 4.39 6667 546676860 ERL87797.1 1674 3.4e-183 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.25643e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8NBJ9 1125 6.3e-121 SID1 transmembrane family member 2 OS=Homo sapiens GN=SIDT2 PE=1 SV=2 PF08030//PF01133//PF00097//PF00175//PF13965 Ferric reductase NAD binding domain//Enhancer of rudimentary//Zinc finger, C3HC4 type (RING finger)//Oxidoreductase NAD-binding domain//dsRNA-gated channel SID-1 GO:0045747//GO:0006221//GO:0015931//GO:0033227//GO:0055114//GO:0007049 positive regulation of Notch signaling pathway//pyrimidine nucleotide biosynthetic process//nucleobase-containing compound transport//dsRNA transport//oxidation-reduction process//cell cycle GO:0016491//GO:0051033//GO:0046872 oxidoreductase activity//RNA transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.38118 BF_2 942.46 18.70 2396 332374950 AEE62616.1 1054 9.4e-112 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15085 SLC25A42 solute carrier family 25, member 42 http://www.genome.jp/dbget-bin/www_bget?ko:K15085 Q86VD7 693 2.8e-71 Mitochondrial coenzyme A transporter SLC25A42 OS=Homo sapiens GN=SLC25A42 PE=2 SV=2 PF13405//PF13833//PF00036//PF13499 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.38119 BF_2 106.98 1.44 3386 91091818 XP_966528.1 1854 2.3e-204 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1223 1.4e-132 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060//PF03594 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Benzoate membrane transport protein GO:0006810//GO:0007268//GO:0042919//GO:0007165//GO:0006811 transport//synaptic transmission//benzoate transport//signal transduction//ion transport GO:0004970//GO:0005234//GO:0042925//GO:0005216 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//benzoate transporter activity//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.38123 BF_2 543.00 13.31 1994 642923056 XP_008200513.1 1026 1.4e-108 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X4 [Tribolium castaneum]>gi|270006595|gb|EFA03043.1| hypothetical protein TcasGA2_TC010469 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H6 574 1.5e-57 Fibronectin type-III domain-containing protein 3A OS=Homo sapiens GN=FNDC3A PE=1 SV=4 PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.38124 BF_2 148.88 1.19 5518 642918063 XP_008193852.1 4540 0.0e+00 PREDICTED: nucleoprotein TPR isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z8P9 1544 1.4e-169 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07926//PF02186//PF05294//PF06005//PF07544 TPR/MLP1/MLP2-like protein//TFIIE beta subunit core domain//Scorpion short toxin//Protein of unknown function (DUF904)//RNA polymerase II transcription mediator complex subunit 9 GO:0006357//GO:0006606//GO:0006367//GO:0043093//GO:0000917//GO:0009405 regulation of transcription from RNA polymerase II promoter//protein import into nucleus//transcription initiation from RNA polymerase II promoter//FtsZ-dependent cytokinesis//barrier septum assembly//pathogenesis GO:0001104 RNA polymerase II transcription cofactor activity GO:0005576//GO:0005737//GO:0016592 extracellular region//cytoplasm//mediator complex KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.38125 BF_2 124.93 0.80 6787 546680752 ERL90967.1 872 3.4e-90 hypothetical protein D910_08309 [Dendroctonus ponderosae] 225543471 NM_001145912.1 198 2.64636e-96 Tribolium castaneum synaptotagmin 1 (Syt1), mRNA K15290 SYT1 synaptotagmin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15290 P21521 764 4.7e-79 Synaptotagmin 1 OS=Drosophila melanogaster GN=Syt1 PE=1 SV=3 PF03821//PF05478//PF00168 Golgi 4-transmembrane spanning transporter//Prominin//C2 domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.38126 BF_2 573.46 3.45 7250 570341960 AHE77377.1 2740 9.0e-307 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 905 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2669 6.3e-300 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF08303//PF05739//PF00106//PF01073//PF02782//PF01370//PF01968//PF00033//PF04625//PF06723//PF01223//PF02491//PF01194 tRNA ligase kinase domain//SNARE domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//FGGY family of carbohydrate kinases, C-terminal domain//NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase//Cytochrome b/b6/petB//DEC-1 protein, N-terminal region//MreB/Mbl protein//DNA/RNA non-specific endonuclease//SHS2 domain inserted in FTSA//RNA polymerases N / 8 kDa subunit GO:0007049//GO:0007304//GO:0006694//GO:0008209//GO:0006206//GO:0006351//GO:0006144//GO:0000902//GO:0008207//GO:0005975//GO:0055114//GO:0008210//GO:0008152//GO:0006388//GO:0022904 cell cycle//chorion-containing eggshell formation//steroid biosynthetic process//androgen metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//cell morphogenesis//C21-steroid hormone metabolic process//carbohydrate metabolic process//oxidation-reduction process//estrogen metabolic process//metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain GO:0016787//GO:0003899//GO:0005213//GO:0050662//GO:0003972//GO:0003677//GO:0003824//GO:0005515//GO:0003854//GO:0005524//GO:0016616//GO:0003676//GO:0016773//GO:0046872//GO:0016491 hydrolase activity//DNA-directed RNA polymerase activity//structural constituent of chorion//coenzyme binding//RNA ligase (ATP) activity//DNA binding//catalytic activity//protein binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//nucleic acid binding//phosphotransferase activity, alcohol group as acceptor//metal ion binding//oxidoreductase activity GO:0042600//GO:0016020//GO:0005576//GO:0005730 chorion//membrane//extracellular region//nucleolus KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.38127 BF_2 167.38 1.23 5986 91089945 XP_973312.1 588 2.6e-57 PREDICTED: eukaryotic translation initiation factor 3 subunit A [Tribolium castaneum]>gi|270013675|gb|EFA10123.1| hypothetical protein TcasGA2_TC012303 [Tribolium castaneum] 642933533 XM_008199237.1 55 7.26541e-17 PREDICTED: Tribolium castaneum protein alan shepard (LOC663083), transcript variant X7, mRNA K03254 EIF3A translation initiation factor 3 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03254 B4QVI2 409 6.0e-38 Eukaryotic translation initiation factor 3 subunit A OS=Drosophila simulans GN=eIF3-S10 PE=3 SV=1 PF02983 Alpha-lytic protease prodomain GO:0006508//GO:0006413//GO:0006446 proteolysis//translational initiation//regulation of translational initiation GO:0003743//GO:0008236 translation initiation factor activity//serine-type peptidase activity GO:0005576//GO:0005840 extracellular region//ribosome KOG2072 Translation initiation factor 3, subunit a (eIF-3a) Cluster-8309.38129 BF_2 51.76 0.67 3495 91089945 XP_973312.1 3473 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit A [Tribolium castaneum]>gi|270013675|gb|EFA10123.1| hypothetical protein TcasGA2_TC012303 [Tribolium castaneum] -- -- -- -- -- K03254 EIF3A translation initiation factor 3 subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K03254 Q173M7 2783 0.0e+00 Eukaryotic translation initiation factor 3 subunit A OS=Aedes aegypti GN=eIF3-S10 PE=3 SV=1 PF01399 PCI domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003743//GO:0005515 translation initiation factor activity//protein binding GO:0005840 ribosome KOG2072 Translation initiation factor 3, subunit a (eIF-3a) Cluster-8309.38130 BF_2 146.38 9.27 948 642912644 XP_008200947.1 466 5.7e-44 PREDICTED: uncharacterized protein LOC103315046 isoform X1 [Tribolium castaneum]>gi|270002621|gb|EEZ99068.1| hypothetical protein TcasGA2_TC004945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00170//PF07716//PF13631//PF01253//PF05791 bZIP transcription factor//Basic region leucine zipper//Cytochrome b(N-terminal)/b6/petB//Translation initiation factor SUI1//Bacillus haemolytic enterotoxin (HBL) GO:0006446//GO:0009405//GO:0006355//GO:0006118//GO:0006413 regulation of translational initiation//pathogenesis//regulation of transcription, DNA-templated//obsolete electron transport//translational initiation GO:0016491//GO:0003743//GO:0003700//GO:0043565//GO:0009055 oxidoreductase activity//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//electron carrier activity GO:0005667//GO:0005840//GO:0016020 transcription factor complex//ribosome//membrane -- -- Cluster-8309.38131 BF_2 30.32 0.49 2856 642919248 XP_008191793.1 999 2.7e-105 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] 170068618 XM_001868902.1 84 2.60604e-33 Culex quinquefasciatus cation efflux protein/ zinc transporter, mRNA K14688 SLC30A1, ZNT1 solute carrier family 30 (zinc transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14688 Q60738 372 5.6e-34 Zinc transporter 1 OS=Mus musculus GN=Slc30a1 PE=1 SV=1 PF01545 Cation efflux family GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.38132 BF_2 4317.33 78.98 2574 91083819 XP_973530.1 2792 0.0e+00 PREDICTED: trifunctional enzyme subunit alpha, mitochondrial [Tribolium castaneum] 689427973 LL903388.1 36 1.13132e-06 Schistocephalus solidus genome assembly S_solidus_NST_G2 ,scaffold SSLN_scaffold0003160 K07515 HADHA enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07515 P40939 1971 1.9e-219 Trifunctional enzyme subunit alpha, mitochondrial OS=Homo sapiens GN=HADHA PE=1 SV=2 PF03446//PF02737//PF02529//PF02609//PF16113//PF00378//PF01048//PF00725 NAD binding domain of 6-phosphogluconate dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Cytochrome B6-F complex subunit 5//Exonuclease VII small subunit//Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase//Phosphorylase superfamily//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO:0006552//GO:0006308//GO:0006631//GO:0006633//GO:0006098//GO:0018874//GO:0008152//GO:0006554//GO:0055114//GO:0019521//GO:0006568//GO:0009116//GO:0006574//GO:0006550 leucine catabolic process//DNA catabolic process//fatty acid metabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//metabolic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process//nucleoside metabolic process//valine catabolic process//isoleucine catabolic process GO:0016491//GO:0008855//GO:0016836//GO:0003824//GO:0003857//GO:0004616 oxidoreductase activity//exodeoxyribonuclease VII activity//hydro-lyase activity//catalytic activity//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity GO:0009512//GO:0009318 cytochrome b6f complex//exodeoxyribonuclease VII complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.38133 BF_2 8661.70 32.97 11277 746835597 XP_011068495.1 2501 7.2e-279 PREDICTED: uncharacterized protein LOC105154570 isoform X8 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q62417 536 2.1e-52 Sorbin and SH3 domain-containing protein 1 OS=Mus musculus GN=Sorbs1 PE=1 SV=2 PF00595//PF00383//PF14604//PF00018//PF12549//PF13180 PDZ domain (Also known as DHR or GLGF)//Cytidine and deoxycytidylate deaminase zinc-binding region//Variant SH3 domain//SH3 domain//Tyrosine hydroxylase N terminal//PDZ domain GO:0006570//GO:0055114 tyrosine metabolic process//oxidation-reduction process GO:0005515//GO:0004511//GO:0008270 protein binding//tyrosine 3-monooxygenase activity//zinc ion binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.38135 BF_2 6106.98 189.82 1633 264667329 ACY71250.1 499 1.5e-47 ribosomal protein L24 [Chrysomela tremula] 40642995 AJ563459.1 48 1.51962e-13 Crassostrea gigas partial mRNA for ribosomal protein L24 (rpl24 gene) K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q6F444 444 1.4e-42 60S ribosomal protein L24 OS=Plutella xylostella GN=RpL24 PE=2 SV=1 PF07565//PF11808 Band 3 cytoplasmic domain//Domain of unknown function (DUF3329) GO:0006820//GO:0016310 anion transport//phosphorylation GO:0004673//GO:0008509 protein histidine kinase activity//anion transmembrane transporter activity GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex KOG1722 60s ribosomal protein L24 Cluster-8309.38136 BF_2 4945.61 75.37 3032 91089929 XP_973045.1 210 8.8e-14 PREDICTED: uncharacterized protein LOC661814 [Tribolium castaneum]>gi|270013559|gb|EFA10007.1| hypothetical protein TcasGA2_TC012177 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168 Triple QxxK/R motif-containing protein family -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.38138 BF_2 3192.23 28.47 4977 270008215 EFA04663.1 163 4.1e-08 chickadee [Tribolium castaneum] 282165793 NM_001170665.1 110 1.60778e-47 Tribolium castaneum chickadee (chic), mRNA -- -- -- -- P25843 159 4.9e-09 Profilin OS=Drosophila melanogaster GN=chic PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38140 BF_2 24.49 0.34 3323 91077504 XP_966852.1 2795 0.0e+00 PREDICTED: prosaposin [Tribolium castaneum]>gi|270001598|gb|EEZ98045.1| hypothetical protein TcasGA2_TC000449 [Tribolium castaneum] -- -- -- -- -- K12382 PSAP, SGP1 saposin http://www.genome.jp/dbget-bin/www_bget?ko:K12382 P26779 409 3.3e-38 Prosaposin OS=Bos taurus GN=PSAP PE=1 SV=3 PF05184//PF02627 Saposin-like type B, region 1//Carboxymuconolactone decarboxylase family GO:0006629//GO:0055114 lipid metabolic process//oxidation-reduction process GO:0051920 peroxiredoxin activity -- -- -- -- Cluster-8309.38142 BF_2 9.00 22.67 276 478253268 ENN73639.1 280 6.0e-23 hypothetical protein YQE_09885, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35554 210 3.3e-16 Flightin OS=Drosophila melanogaster GN=fln PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38143 BF_2 396.26 3.41 5146 859132801 AKO63316.1 1769 2.5e-194 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 Q6GN02 1393 4.1e-152 Acetyl-CoA acetyltransferase B, mitochondrial OS=Xenopus laevis GN=acat1-b PE=2 SV=1 PF14634//PF02803//PF00108 zinc-RING finger domain//Thiolase, C-terminal domain//Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747//GO:0005515//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//zinc ion binding -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.38146 BF_2 516.88 7.03 3364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.38147 BF_2 825.12 13.65 2816 270015414 EFA11862.1 1358 6.2e-147 hypothetical protein TcasGA2_TC005104 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38149 BF_2 35.43 0.34 4658 646722544 KDR23502.1 4185 0.0e+00 Dual oxidase 2 [Zootermopsis nevadensis] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9NRD9 2232 1.9e-249 Dual oxidase 1 OS=Homo sapiens GN=DUOX1 PE=1 SV=1 PF13202//PF08030//PF03185//PF08022//PF15048//PF00036//PF12763//PF00175//PF13499//PF13833//PF13405 EF hand//Ferric reductase NAD binding domain//Calcium-activated potassium channel, beta subunit//FAD-binding domain//Organic solute transporter subunit beta protein//EF hand//Cytoskeletal-regulatory complex EF hand//Oxidoreductase NAD-binding domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain GO:0015721//GO:0006810//GO:0006813//GO:0055114 bile acid and bile salt transport//transport//potassium ion transport//oxidation-reduction process GO:0016491//GO:0046982//GO:0005515//GO:0015269//GO:0005215//GO:0005509 oxidoreductase activity//protein heterodimerization activity//protein binding//calcium-activated potassium channel activity//transporter activity//calcium ion binding GO:0005886//GO:0016020 plasma membrane//membrane KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.38151 BF_2 2388.37 25.72 4172 478251554 ENN72016.1 1206 3.9e-129 hypothetical protein YQE_11307, partial [Dendroctonus ponderosae]>gi|546681219|gb|ERL91354.1| hypothetical protein D910_08686 [Dendroctonus ponderosae] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 860 2.1e-90 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 PF01745 Isopentenyl transferase GO:0016114//GO:0006694//GO:0009058 terpenoid biosynthetic process//steroid biosynthetic process//biosynthetic process GO:0004161 dimethylallyltranstransferase activity -- -- KOG0787 Dehydrogenase kinase Cluster-8309.38152 BF_2 30.85 3.15 697 642927179 XP_008195168.1 544 3.8e-53 PREDICTED: dihydrofolate reductase [Tribolium castaneum] 389612312 AK403254.1 35 1.06284e-06 Papilio xuthus mRNA for dihydrofolate reductase, partial cds, sequence id: Px-1353, expressed in epidermis K00287 folA dihydrofolate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00287 Q9U8B8 387 2.5e-36 Dihydrofolate reductase OS=Heliothis virescens GN=DHFR PE=1 SV=1 PF00186 Dihydrofolate reductase GO:0006761//GO:0046656//GO:0009165//GO:0055114//GO:0006545 dihydrofolate biosynthetic process//folic acid biosynthetic process//nucleotide biosynthetic process//oxidation-reduction process//glycine biosynthetic process GO:0004146 dihydrofolate reductase activity -- -- KOG1324 Dihydrofolate reductase Cluster-8309.38154 BF_2 1465.08 7.26 8725 91090139 XP_971650.1 2671 1.1e-298 PREDICTED: WEB family protein At3g02930, chloroplastic [Tribolium castaneum]>gi|270013743|gb|EFA10191.1| hypothetical protein TcasGA2_TC012383 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38155 BF_2 776.99 17.38 2157 546679644 ERL90075.1 1983 1.6e-219 hypothetical protein D910_07430, partial [Dendroctonus ponderosae] 815900771 XM_012381089.1 91 2.51962e-37 PREDICTED: Bombus impatiens lateral signaling target protein 2 homolog (LOC100747478), transcript variant X2, mRNA -- -- -- -- B4M140 1060 7.0e-114 Lateral signaling target protein 2 homolog OS=Drosophila virilis GN=GJ23073 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1819 FYVE finger-containing proteins Cluster-8309.38156 BF_2 153.72 6.95 1212 91091522 XP_969887.1 335 1.1e-28 PREDICTED: frataxin homolog, mitochondrial [Tribolium castaneum]>gi|270001018|gb|EEZ97465.1| hypothetical protein TcasGA2_TC011296 [Tribolium castaneum] -- -- -- -- -- K19054 FXN frataxin http://www.genome.jp/dbget-bin/www_bget?ko:K19054 Q9W385 293 3.4e-25 Frataxin homolog, mitochondrial OS=Drosophila melanogaster GN=fh PE=2 SV=1 PF01491 Frataxin-like domain GO:0016226 iron-sulfur cluster assembly GO:0008199 ferric iron binding -- -- KOG3413 Mitochondrial matrix protein frataxin, involved in Fe/S protein biosynthesis Cluster-8309.38158 BF_2 3928.76 23.76 7203 646710887 KDR16277.1 5755 0.0e+00 Myosin-XVIIIa, partial [Zootermopsis nevadensis] 817181759 XM_012425868.1 44 1.13959e-10 PREDICTED: Orussus abietinus unconventional myosin-XVIIIa (LOC105699960), transcript variant X6, mRNA K10362 MYO18 myosin XVIII http://www.genome.jp/dbget-bin/www_bget?ko:K10362 Q92614 3238 0.0e+00 Unconventional myosin-XVIIIa OS=Homo sapiens GN=MYO18A PE=1 SV=3 PF01576//PF00063//PF00612//PF00595//PF01213//PF13180//PF01418//PF00005 Myosin tail//Myosin head (motor domain)//IQ calmodulin-binding motif//PDZ domain (Also known as DHR or GLGF)//Adenylate cyclase associated (CAP) N terminal//PDZ domain//Helix-turn-helix domain, rpiR family//ABC transporter GO:0006355//GO:0007010 regulation of transcription, DNA-templated//cytoskeleton organization GO:0003774//GO:0016887//GO:0003700//GO:0005524//GO:0005515//GO:0003779 motor activity//ATPase activity//transcription factor activity, sequence-specific DNA binding//ATP binding//protein binding//actin binding GO:0016459//GO:0005667 myosin complex//transcription factor complex KOG0161 Myosin class II heavy chain Cluster-8309.38160 BF_2 24.67 0.41 2823 91078460 XP_967570.1 1148 1.4e-122 PREDICTED: tether containing UBX domain for GLUT4-like [Tribolium castaneum] -- -- -- -- -- K15627 ASPSCR1, ASPL tether containing UBX domain for GLUT4 http://www.genome.jp/dbget-bin/www_bget?ko:K15627 Q9BZE9 487 2.6e-47 Tether containing UBX domain for GLUT4 OS=Homo sapiens GN=ASPSCR1 PE=1 SV=1 PF00789//PF02196 UBX domain//Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057//GO:0005515 receptor signaling protein activity//protein binding -- -- KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.38161 BF_2 3106.47 159.29 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38163 BF_2 575.25 4.01 6282 546673472 ERL85070.1 2710 2.3e-303 hypothetical protein D910_02493 [Dendroctonus ponderosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 Q27772 2373 1.1e-265 C-1-tetrahydrofolate synthase, cytoplasmic OS=Spodoptera frugiperda PE=2 SV=3 PF01268//PF05175//PF01795//PF01189//PF09445 Formate--tetrahydrofolate ligase//Methyltransferase small domain//MraW methylase family//16S rRNA methyltransferase RsmF//RNA cap guanine-N2 methyltransferase GO:0009396//GO:0046487//GO:0009452//GO:0001510 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0005524//GO:0008168//GO:0004329 ATP binding//methyltransferase activity//formate-tetrahydrofolate ligase activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.38164 BF_2 7.74 0.70 750 478252441 ENN72864.1 297 1.8e-24 hypothetical protein YQE_10513, partial [Dendroctonus ponderosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 234 1.5e-18 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF01268 Formate--tetrahydrofolate ligase GO:0046487//GO:0009396 glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0004329//GO:0005524 formate-tetrahydrofolate ligase activity//ATP binding -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.38168 BF_2 516.04 6.46 3627 642936487 XP_008198457.1 2312 1.9e-257 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.44737e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1216 9.6e-132 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF05699//PF01699//PF10613//PF00060 hAT family C-terminal dimerisation region//Sodium/calcium exchanger protein//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006811//GO:0055085//GO:0007165//GO:0007268 ion transport//transmembrane transport//signal transduction//synaptic transmission GO:0005216//GO:0004970//GO:0005234//GO:0046983 ion channel activity//ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//protein dimerization activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.38169 BF_2 27.97 0.54 2473 727098932 AIY54299.1 674 1.1e-67 glyceraldehyde 3-phosphate dehydrogenase [Colaphellus bowringi] 290756693 GU580820.1 73 2.93608e-27 Drepana curvatula voucher NS48 glyceraldhyde-3-phosphate dehydrogenase (GAPDH) gene, partial cds >gnl|BL_ORD_ID|8311285 Thyatira batis voucher MM00027 glyceraldhyde-3-phosphate dehydrogenase (GAPDH) gene, partial cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q4U3L0 584 1.3e-58 Glyceraldehyde-3-phosphate dehydrogenase OS=Glossina morsitans morsitans GN=Gapdh PE=2 SV=1 PF00208//PF00044//PF00107//PF02826 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0006520 oxidation-reduction process//cellular amino acid metabolic process GO:0051287//GO:0016620//GO:0016491 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.38172 BF_2 101.07 0.59 7470 642920095 XP_008192202.1 1816 1.3e-199 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 8.27617e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.2e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.38173 BF_2 44.31 3.47 821 332375664 AEE62973.1 174 3.5e-10 unknown [Dendroctonus ponderosae]>gi|478254613|gb|ENN74856.1| hypothetical protein YQE_08626, partial [Dendroctonus ponderosae]>gi|546673364|gb|ERL84987.1| hypothetical protein D910_02410 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3ZC48 125 7.0e-06 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38175 BF_2 4022.82 100.66 1959 646701112 KDR10996.1 1681 1.5e-184 Aspartate aminotransferase, mitochondrial [Zootermopsis nevadensis] 170040613 XM_001848036.1 108 8.10115e-47 Culex quinquefasciatus aspartate aminotransferase, mRNA K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 1532 1.2e-168 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.38176 BF_2 1156.95 29.16 1947 332372484 AEE61384.1 1870 1.8e-206 unknown [Dendroctonus ponderosae]>gi|478263185|gb|ENN81578.1| hypothetical protein YQE_02107, partial [Dendroctonus ponderosae]>gi|546681813|gb|ERL91839.1| hypothetical protein D910_09164 [Dendroctonus ponderosae] 170040613 XM_001848036.1 79 1.06375e-30 Culex quinquefasciatus aspartate aminotransferase, mRNA K14455 GOT2 aspartate aminotransferase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K14455 P00507 1492 5.1e-164 Aspartate aminotransferase, mitochondrial OS=Rattus norvegicus GN=Got2 PE=1 SV=2 PF00155 Aminotransferase class I and II GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1411 Aspartate aminotransferase/Glutamic oxaloacetic transaminase AAT1/GOT2 Cluster-8309.38177 BF_2 199.00 3.24 2858 478252874 ENN73263.1 344 2.4e-29 hypothetical protein YQE_10158, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VBV3 190 7.1e-13 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38179 BF_2 613.11 12.86 2282 91086399 XP_974859.1 2065 5.3e-229 PREDICTED: 26S protease regulatory subunit 4 [Tribolium castaneum]>gi|270010293|gb|EFA06741.1| hypothetical protein TcasGA2_TC009675 [Tribolium castaneum] 829812394 XM_012773957.1 384 0 PREDICTED: Microcebus murinus proteasome (prosome, macropain) 26S subunit, ATPase, 1 (PSMC1), mRNA K03062 PSMC1, RPT2 26S proteasome regulatory subunit T2 http://www.genome.jp/dbget-bin/www_bget?ko:K03062 P48601 1995 2.8e-222 26S protease regulatory subunit 4 OS=Drosophila melanogaster GN=Rpt2 PE=1 SV=2 PF00910//PF00931//PF02562//PF02367//PF00005//PF07726//PF07724//PF00004//PF01057//PF05496//PF00158//PF06068//PF01695//PF07728 RNA helicase//NB-ARC domain//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily) GO:0030163//GO:0006310//GO:0002949//GO:0006355//GO:0006281//GO:0019079 protein catabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA repair//viral genome replication GO:0003724//GO:0017111//GO:0009378//GO:0043531//GO:0003723//GO:0003678//GO:0016887//GO:0008134//GO:0005524 RNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//ADP binding//RNA binding//DNA helicase activity//ATPase activity//transcription factor binding//ATP binding GO:0005667//GO:0005657//GO:0005737//GO:0009379 transcription factor complex//replication fork//cytoplasm//Holliday junction helicase complex KOG0726 26S proteasome regulatory complex, ATPase RPT2 Cluster-8309.38180 BF_2 670.27 11.38 2750 91077014 XP_966444.1 1721 4.9e-189 PREDICTED: myc box-dependent-interacting protein 1 isoform X1 [Tribolium castaneum] 817188757 XM_012433541.1 206 3.80115e-101 PREDICTED: Orussus abietinus amphiphysin (LOC105704379), transcript variant X2, mRNA K12562 AMPH amphiphysin http://www.genome.jp/dbget-bin/www_bget?ko:K12562 P50478 529 3.4e-52 Amphiphysin OS=Gallus gallus GN=AMPH PE=2 SV=1 PF02255//PF06456//PF03114//PF14604//PF00018 PTS system, Lactose/Cellobiose specific IIA subunit//Arfaptin-like domain//BAR domain//Variant SH3 domain//SH3 domain GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0019904 protein binding//protein domain specific binding GO:0005737 cytoplasm KOG3771 Amphiphysin Cluster-8309.38181 BF_2 1.00 0.66 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38182 BF_2 814.76 24.83 1660 91080341 XP_974659.1 1374 5.1e-149 PREDICTED: ADP-ribosylation factor GTPase-activating protein 2 [Tribolium castaneum]>gi|270005715|gb|EFA02163.1| hypothetical protein TcasGA2_TC007817 [Tribolium castaneum] -- -- -- -- -- K12493 ARFGAP2_3 ADP-ribosylation factor GTPase-activating protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12493 Q4R4C9 788 1.9e-82 ADP-ribosylation factor GTPase-activating protein 3 OS=Macaca fascicularis GN=ARFGAP3 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0706 Predicted GTPase-activating protein Cluster-8309.38184 BF_2 681.33 19.09 1780 91090188 XP_966752.1 1341 3.7e-145 PREDICTED: tetraspanin-33 [Tribolium castaneum]>gi|270013472|gb|EFA09920.1| hypothetical protein TcasGA2_TC012071 [Tribolium castaneum] -- -- -- -- -- K17346 TSPAN33 tetraspanin-33 http://www.genome.jp/dbget-bin/www_bget?ko:K17346 Q8R3S2 559 7.2e-56 Tetraspanin-33 OS=Mus musculus GN=Tspan33 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.38187 BF_2 245.53 2.02 5382 642925975 XP_967431.2 283 5.3e-22 PREDICTED: uncharacterized protein LOC655776 [Tribolium castaneum] -- -- -- -- -- K17558 PPP1R15B, CREP protein phosphatase 1 regulatory subunit 15B http://www.genome.jp/dbget-bin/www_bget?ko:K17558 Q2KI51 135 3.2e-06 Protein phosphatase 1 regulatory subunit 15A OS=Bos taurus GN=PPP1R15A PE=2 SV=2 PF11403 Yeast metallothionein GO:0071585//GO:0010273 detoxification of cadmium ion//detoxification of copper ion GO:0005507//GO:0046870 copper ion binding//cadmium ion binding -- -- -- -- Cluster-8309.38189 BF_2 1645.97 10.72 6708 642935636 XP_008198092.1 5460 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X1 [Tribolium castaneum] 642935647 XM_008199876.1 264 5.3498e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.0e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF13180//PF00620//PF00595 Glycolipid transfer protein (GLTP)//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0046836//GO:0007165 glycolipid transport//signal transduction GO:0005515//GO:0051861//GO:0017089 protein binding//glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.38191 BF_2 341.36 4.65 3355 91087179 XP_975411.1 767 2.5e-78 PREDICTED: flavin reductase (NADPH) [Tribolium castaneum]>gi|270010563|gb|EFA07011.1| hypothetical protein TcasGA2_TC009981 [Tribolium castaneum] -- -- -- -- -- K05901 BLVRB biliverdin reductase / flavin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K05901 P52556 382 4.5e-35 Flavin reductase (NADPH) OS=Bos taurus GN=BLVRB PE=1 SV=2 PF13508//PF00583//PF13302//PF13673 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0000166 N-acetyltransferase activity//nucleotide binding -- -- KOG3397 Acetyltransferases Cluster-8309.38192 BF_2 47.62 0.34 6217 91077030 XP_967400.1 1924 3.2e-212 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1115 8.5e-120 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF03709//PF07714//PF05028//PF03604//PF00069//PF01029//PF06293 Orn/Lys/Arg decarboxylase, N-terminal domain//Protein tyrosine kinase//Poly (ADP-ribose) glycohydrolase (PARG)//DNA directed RNA polymerase, 7 kDa subunit//Protein kinase domain//NusB family//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0005975//GO:0006355//GO:0006144//GO:0006351//GO:0006206 protein phosphorylation//carbohydrate metabolic process//regulation of transcription, DNA-templated//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0005524//GO:0003899//GO:0016831//GO:0003723//GO:0003677//GO:0004649//GO:0004672//GO:0016773 ATP binding//DNA-directed RNA polymerase activity//carboxy-lyase activity//RNA binding//DNA binding//poly(ADP-ribose) glycohydrolase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005730//GO:0016020 nucleolus//membrane KOG3087 Serine/threonine protein kinase Cluster-8309.38193 BF_2 108.00 6.50 982 91089443 XP_967760.1 702 2.5e-71 PREDICTED: protein transport protein SFT2 [Tribolium castaneum]>gi|270012564|gb|EFA09012.1| hypothetical protein TcasGA2_TC006720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P6K1 175 1.3e-11 Protein transport protein sft2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sft2 PE=3 SV=1 PF05371//PF04178 Phage major coat protein, Gp8//Got1/Sft2-like family GO:0016192 vesicle-mediated transport -- -- GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG2887 Membrane protein involved in ER to Golgi transport Cluster-8309.38195 BF_2 1153.20 10.44 4909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.38197 BF_2 208.63 5.23 1956 91084833 XP_966469.1 512 5.4e-49 PREDICTED: inositol oxygenase [Tribolium castaneum]>gi|270008967|gb|EFA05415.1| hypothetical protein TcasGA2_TC015591 [Tribolium castaneum] -- -- -- -- -- K00469 MIOX inositol oxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00469 Q4V8T0 426 2.1e-40 Inositol oxygenase OS=Danio rerio GN=miox PE=2 SV=1 PF05153 Myo-inositol oxygenase GO:0055114//GO:0019310 oxidation-reduction process//inositol catabolic process GO:0050113//GO:0005506 inositol oxygenase activity//iron ion binding GO:0005737 cytoplasm KOG1573 Aldehyde reductase Cluster-8309.38198 BF_2 290.17 1.89 6725 546675258 ERL86494.1 972 8.5e-102 hypothetical protein D910_03898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P70478 235 1.0e-17 Adenomatous polyposis coli protein OS=Rattus norvegicus GN=Apc PE=1 SV=1 PF05972//PF05923//PF04072//PF05924 APC 15 residue motif//APC cysteine-rich region//Leucine carboxyl methyltransferase//SAMP Motif GO:0016055//GO:0032259 Wnt signaling pathway//methylation GO:0008168//GO:0008013 methyltransferase activity//beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.38199 BF_2 204.00 1.75 5153 642923911 XP_008193924.1 2383 1.6e-265 PREDICTED: nucleolar protein 10 [Tribolium castaneum]>gi|270007790|gb|EFA04238.1| hypothetical protein TcasGA2_TC014492 [Tribolium castaneum] 817185075 XM_012429433.1 112 1.28716e-48 PREDICTED: Orussus abietinus nucleolar protein 10 (LOC105702116), transcript variant X1, mRNA K14788 NOL10, ENP2 ribosome biogenesis protein ENP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14788 Q7T0Q5 1808 3.1e-200 Nucleolar protein 10 OS=Xenopus laevis GN=nol10 PE=2 SV=1 PF08159 NUC153 domain -- -- -- -- GO:0005634 nucleus KOG2321 WD40 repeat protein Cluster-8309.38203 BF_2 4488.56 58.19 3514 91091500 XP_968802.1 950 1.6e-99 PREDICTED: GTP-binding protein SAR1b [Tribolium castaneum]>gi|270001011|gb|EEZ97458.1| hypothetical protein TcasGA2_TC011289 [Tribolium castaneum] 755868190 XM_005181111.2 172 3.87375e-82 PREDICTED: Musca domestica GTP-binding protein SAR1b (LOC101900022), mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q9CQC9 750 1.0e-77 GTP-binding protein SAR1b OS=Mus musculus GN=Sar1b PE=1 SV=1 PF00025//PF08477//PF01926//PF00503//PF05493//PF06858//PF10662//PF00071//PF04670 ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//ATP synthase subunit H//Nucleolar GTP-binding protein 1 (NOG1)//Ethanolamine utilisation - propanediol utilisation//Ras family//Gtr1/RagA G protein conserved region GO:0015992//GO:0007186//GO:0006886//GO:0016192//GO:0007165//GO:0007264//GO:0015991//GO:0006576 proton transport//G-protein coupled receptor signaling pathway//intracellular protein transport//vesicle-mediated transport//signal transduction//small GTPase mediated signal transduction//ATP hydrolysis coupled proton transport//cellular biogenic amine metabolic process GO:0019001//GO:0015078//GO:0003924//GO:0031683//GO:0005524//GO:0004871//GO:0005525 guanyl nucleotide binding//hydrogen ion transmembrane transporter activity//GTPase activity//G-protein beta/gamma-subunit complex binding//ATP binding//signal transducer activity//GTP binding GO:0005794//GO:0033179//GO:0005783 Golgi apparatus//proton-transporting V-type ATPase, V0 domain//endoplasmic reticulum KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.38204 BF_2 877.91 6.87 5632 332376995 AEE63637.1 1603 4.8e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 264 4.48912e-133 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 4.7e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00769//PF01233//PF00487 Ezrin/radixin/moesin family//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//Fatty acid desaturase GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0008092//GO:0004379 cytoskeletal protein binding//glycylpeptide N-tetradecanoyltransferase activity GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2987 Fatty acid desaturase Cluster-8309.38206 BF_2 16.77 0.43 1935 642917912 XP_008191379.1 1024 2.3e-108 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9GLD9 552 5.1e-55 UDP-glucuronosyltransferase 2B33 OS=Macaca mulatta GN=UGT2B33 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.38207 BF_2 858.22 15.60 2588 646700583 KDR10693.1 2381 1.4e-265 Propionyl-CoA carboxylase alpha chain, mitochondrial [Zootermopsis nevadensis] 852460626 CP011799.1 37 3.16282e-07 Streptomyces sp. PBH53 genome K01965 PCCA, pccA propionyl-CoA carboxylase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01965 P05165 2116 3.0e-236 Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Homo sapiens GN=PCCA PE=1 SV=4 PF02655//PF07478//PF02786 ATP-grasp domain//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain GO:0009252//GO:0046436 peptidoglycan biosynthetic process//D-alanine metabolic process GO:0046872//GO:0008716//GO:0005524 metal ion binding//D-alanine-D-alanine ligase activity//ATP binding -- -- KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit Cluster-8309.38210 BF_2 126.00 5.06 1329 91093459 XP_967209.1 1340 3.6e-145 PREDICTED: uncharacterized protein LOC655563 [Tribolium castaneum] 642930682 XM_962116.2 135 5.33407e-62 PREDICTED: Tribolium castaneum uncharacterized LOC655563 (LOC655563), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38211 BF_2 65.51 1.81 1799 646700412 KDR10573.1 1580 7.2e-173 Adenylosuccinate synthetase [Zootermopsis nevadensis] -- -- -- -- -- K01939 purA, ADSS adenylosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01939 Q17G75 1538 2.2e-169 Adenylosuccinate synthetase OS=Aedes aegypti GN=AAEL003161 PE=3 SV=1 PF00709//PF01640 Adenylosuccinate synthetase//Peptidase C10 family GO:0006164//GO:0006531//GO:0006144//GO:0006522//GO:0006508 purine nucleotide biosynthetic process//aspartate metabolic process//purine nucleobase metabolic process//alanine metabolic process//proteolysis GO:0008234//GO:0005525//GO:0004019 cysteine-type peptidase activity//GTP binding//adenylosuccinate synthase activity -- -- KOG1355 Adenylosuccinate synthase Cluster-8309.38212 BF_2 455.73 6.17 3376 91090103 XP_970810.1 1845 2.5e-203 PREDICTED: E3 ubiquitin-protein ligase MGRN1 isoform X2 [Tribolium castaneum]>gi|270013734|gb|EFA10182.1| hypothetical protein TcasGA2_TC012374 [Tribolium castaneum] 160947857 EU258622.1 288 1.2204e-146 Spodoptera exigua ribosomal protein L10 (RpL10) mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O96647 1088 6.2e-117 60S ribosomal protein L10 OS=Bombyx mandarina GN=RpL10 PE=2 SV=1 PF13639//PF00252//PF14634//PF03854 Ring finger domain//Ribosomal protein L16p/L10e//zinc-RING finger domain//P-11 zinc finger GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735//GO:0008270//GO:0005515 RNA binding//structural constituent of ribosome//zinc ion binding//protein binding GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.38213 BF_2 126.54 5.06 1333 189236439 XP_001814289.1 1020 4.6e-108 PREDICTED: uncharacterized protein LOC100142575 [Tribolium castaneum]>gi|270005928|gb|EFA02376.1| hypothetical protein TcasGA2_TC008051 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38215 BF_2 364.18 14.78 1318 642936134 XP_008198313.1 1531 2.5e-167 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 337 2.70502e-174 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q55EH8 566 8.2e-57 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF13304//PF01637//PF03193//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter -- -- GO:0003924//GO:0005524//GO:0005525//GO:0016887 GTPase activity//ATP binding//GTP binding//ATPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.38216 BF_2 470.81 6.37 3380 270012664 EFA09112.1 2981 0.0e+00 hypothetical protein TcasGA2_TC015972 [Tribolium castaneum] 462330734 APGK01039925.1 69 6.73678e-25 Dendroctonus ponderosae Seq01039935, whole genome shotgun sequence -- -- -- -- Q8TBP0 1284 1.2e-139 TBC1 domain family member 16 OS=Homo sapiens GN=TBC1D16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.38218 BF_2 24.07 0.40 2805 270014457 EFA10905.1 2538 9.2e-284 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 866 2.9e-91 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF01289//PF00665 Thiol-activated cytolysin//Integrase core domain GO:0009405//GO:0015074 pathogenesis//DNA integration GO:0015485 cholesterol binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.38220 BF_2 81.00 5.64 888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38224 BF_2 758.37 2.41 13456 189234010 XP_972656.2 5079 0.0e+00 PREDICTED: microtubule-associated serine/threonine-protein kinase 3 isoform X4 [Tribolium castaneum]>gi|270014736|gb|EFA11184.1| hypothetical protein TcasGA2_TC004792 [Tribolium castaneum] 642911788 XM_967563.3 622 0 PREDICTED: Tribolium castaneum microtubule-associated serine/threonine-protein kinase 3 (LOC661405), transcript variant X4, mRNA K08789 MAST microtubule-associated serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08789 Q811L6 2418 1.5e-270 Microtubule-associated serine/threonine-protein kinase 4 OS=Mus musculus GN=Mast4 PE=2 SV=3 PF08926//PF06293//PF00069//PF00595//PF00412//PF07714//PF13180 Domain of unknown function (DUF1908)//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//PDZ domain (Also known as DHR or GLGF)//LIM domain//Protein tyrosine kinase//PDZ domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0008270//GO:0004672//GO:0004674//GO:0000287//GO:0005524//GO:0005515 phosphotransferase activity, alcohol group as acceptor//zinc ion binding//protein kinase activity//protein serine/threonine kinase activity//magnesium ion binding//ATP binding//protein binding GO:0016020 membrane KOG0606 Microtubule-associated serine/threonine kinase and related proteins Cluster-8309.38226 BF_2 468.33 3.61 5721 642928449 XP_008193790.1 3415 0.0e+00 PREDICTED: transcriptional-regulating factor 1 isoform X2 [Tribolium castaneum] 642928448 XM_008195568.1 503 0 PREDICTED: Tribolium castaneum transcriptional-regulating factor 1 (LOC103313127), transcript variant X2, mRNA -- -- -- -- Q08DG8 213 3.1e-15 Zinc finger protein 135 OS=Bos taurus GN=ZNF135 PE=2 SV=1 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.38229 BF_2 13.56 0.38 1799 332376787 AEE63533.1 272 3.4e-21 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 780659103 XM_011694063.1 55 2.15466e-17 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 244 2.4e-19 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF02776//PF00270 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//DEAD/DEAH box helicase -- -- GO:0030976//GO:0005524//GO:0003676 thiamine pyrophosphate binding//ATP binding//nucleic acid binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.38230 BF_2 21897.66 112.23 8449 91085895 XP_968071.1 2691 5.0e-301 PREDICTED: nucleolar protein 6 [Tribolium castaneum]>gi|270009966|gb|EFA06414.1| hypothetical protein TcasGA2_TC009293 [Tribolium castaneum] 158524687 EU074287.1 98 1.28215e-40 Alcyonidium diaphanum methionine adenosyltransferase mRNA, partial cds K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 P40320 1680 3.5e-185 S-adenosylmethionine synthase OS=Drosophila melanogaster GN=Sam-S PE=2 SV=2 PF00961//PF02772//PF05864//PF00438//PF02773//PF00580 LAGLIDADG endonuclease//S-adenosylmethionine synthetase, central domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//S-adenosylmethionine synthetase, N-terminal domain//S-adenosylmethionine synthetase, C-terminal domain//UvrD/REP helicase N-terminal domain GO:0006556//GO:0006206//GO:0006555//GO:0006351//GO:0006144 S-adenosylmethionine biosynthetic process//pyrimidine nucleobase metabolic process//methionine metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0004478//GO:0003677//GO:0004519//GO:0003899//GO:0005524 methionine adenosyltransferase activity//DNA binding//endonuclease activity//DNA-directed RNA polymerase activity//ATP binding GO:0005730 nucleolus KOG1506 S-adenosylmethionine synthetase Cluster-8309.38231 BF_2 291.00 17.83 970 546685525 ERL95012.1 792 9.1e-82 hypothetical protein D910_12282 [Dendroctonus ponderosae] 704288483 XM_010159848.1 45 4.14249e-12 PREDICTED: Eurypyga helias phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform-like (LOC104515752), partial mRNA K00871 PHKG phosphorylase kinase gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00871 Q9DB30 533 4.0e-53 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform OS=Mus musculus GN=Phkg2 PE=2 SV=2 PF05194//PF01764//PF07714//PF06293//PF00069 UreE urease accessory protein, C-terminal domain//Lipase (class 3)//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0019627//GO:0006629//GO:0006461 protein phosphorylation//urea metabolic process//lipid metabolic process//protein complex assembly GO:0016151//GO:0005524//GO:0004672//GO:0016773 nickel cation binding//ATP binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.38232 BF_2 1463.00 18.65 3569 642929032 XP_008195661.1 2709 1.7e-303 PREDICTED: 5'-3' exoribonuclease 2 homolog [Tribolium castaneum] 759098400 XM_011370835.1 74 1.18262e-27 PREDICTED: Pteropus vampyrus 5'-3' exoribonuclease 2 (XRN2), mRNA K12619 XRN2, RAT1 5'-3' exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12619 Q9VM71 2052 1.1e-228 5'-3' exoribonuclease 2 homolog OS=Drosophila melanogaster GN=Rat1 PE=1 SV=2 PF00098//PF03159 Zinc knuckle//XRN 5'-3' exonuclease N-terminus -- -- GO:0004527//GO:0003676//GO:0008270 exonuclease activity//nucleic acid binding//zinc ion binding -- -- KOG2044 5'-3' exonuclease HKE1/RAT1 Cluster-8309.38233 BF_2 18.59 0.41 2205 478262423 ENN81094.1 2576 2.8e-288 hypothetical protein YQE_02462, partial [Dendroctonus ponderosae]>gi|546673644|gb|ERL85208.1| hypothetical protein D910_02629 [Dendroctonus ponderosae] 591382847 XM_007065827.1 100 2.55845e-42 PREDICTED: Chelonia mydas cullin-associated and neddylation-dissociated 1 (CAND1), transcript variant X1, mRNA K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 1804 3.8e-200 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1824 TATA-binding protein-interacting protein Cluster-8309.38234 BF_2 96.56 1.58 2846 642916614 XP_008191899.1 1314 7.9e-142 PREDICTED: LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [Tribolium castaneum] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 3.5e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.38235 BF_2 97.78 1.15 3850 478254875 ENN75111.1 1428 6.5e-155 hypothetical protein YQE_08424, partial [Dendroctonus ponderosae] 642926583 XM_962896.2 307 3.82028e-157 PREDICTED: Tribolium castaneum lipoma-preferred partner homolog (LOC656358), transcript variant X2, mRNA K16676 LPP lipoma-prefererred partner http://www.genome.jp/dbget-bin/www_bget?ko:K16676 Q5F464 812 7.2e-85 Lipoma-preferred partner homolog OS=Gallus gallus GN=LPP PE=2 SV=1 PF06467//PF00412 MYM-type Zinc finger with FCS sequence motif//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.38237 BF_2 133.54 13.43 703 270003282 EEZ99729.1 276 4.5e-22 hypothetical protein TcasGA2_TC002496 [Tribolium castaneum] 347810671 JN410829.1 87 1.32966e-35 Plutella xylostella tyrosine hydroxylase mRNA, complete cds K00501 TH tyrosine 3-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00501 P18459 261 1.0e-21 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38238 BF_2 1696.97 5.00 14472 642924616 XP_008194365.1 1950 7.2e-215 PREDICTED: uncharacterized protein LOC663601 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 2.0e-71 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF00891//PF12529//PF05933//PF01833//PF00554 O-methyltransferase//Xylosyltransferase C terminal//Fungal ATP synthase protein 8 (A6L)//IPT/TIG domain//Rel homology DNA-binding domain GO:0006024//GO:0015986//GO:0006355//GO:0030206//GO:0015992 glycosaminoglycan biosynthetic process//ATP synthesis coupled proton transport//regulation of transcription, DNA-templated//chondroitin sulfate biosynthetic process//proton transport GO:0008171//GO:0003677//GO:0005515//GO:0015078//GO:0030158//GO:0003700 O-methyltransferase activity//DNA binding//protein binding//hydrogen ion transmembrane transporter activity//protein xylosyltransferase activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0000276 transcription factor complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.38239 BF_2 1307.74 23.06 2659 91084515 XP_967225.1 751 1.4e-76 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891//GO:0003723 endoribonuclease activity, producing 5'-phosphomonoesters//RNA binding -- -- -- -- Cluster-8309.3824 BF_2 21.00 0.49 2086 39726003 AAR29953.1 1432 1.2e-155 calreticulin [Ixodes ovatus] 39725998 AY395265.1 317 5.67346e-163 Ixodes muris calreticulin gene, complete cds K08057 CALR calreticulin http://www.genome.jp/dbget-bin/www_bget?ko:K08057 P15253 1295 3.8e-141 Calreticulin OS=Oryctolagus cuniculus GN=CALR PE=1 SV=1 PF00262 Calreticulin family GO:0006457 protein folding GO:0051082//GO:0005509 unfolded protein binding//calcium ion binding GO:0005783 endoplasmic reticulum KOG0674 Calreticulin Cluster-8309.38241 BF_2 298.00 6.66 2160 478252042 ENN72473.1 843 2.5e-87 hypothetical protein YQE_10815, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38242 BF_2 126.30 0.91 6093 642932227 XP_008194631.1 501 3.2e-47 PREDICTED: transforming growth factor beta-1-induced transcript 1 protein-like isoform X4 [Tribolium castaneum] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 247 3.7e-19 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF00412//PF01853//PF01258 LIM domain//MOZ/SAS family//Prokaryotic dksA/traR C4-type zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0016747//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.38243 BF_2 171.88 1.19 6339 91083737 XP_970914.1 1523 1.0e-165 PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|642924379|ref|XP_008194272.1| PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|270007890|gb|EFA04338.1| hypothetical protein TcasGA2_TC014632 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 721 4.2e-74 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF11095//PF00155//PF08115//PF04834//PF02854 Gem-associated protein 7 (Gemin7)//Aminotransferase class I and II//SFI toxin family//Early E3 14.5 kDa protein//MIF4G domain GO:0009058//GO:0009405//GO:0009966//GO:0016070 biosynthetic process//pathogenesis//regulation of signal transduction//RNA metabolic process GO:0003677//GO:0003723//GO:0005515//GO:0030170 DNA binding//RNA binding//protein binding//pyridoxal phosphate binding GO:0005576//GO:0032797//GO:0016021 extracellular region//SMN complex//integral component of membrane KOG0259 Tyrosine aminotransferase Cluster-8309.38244 BF_2 4821.15 109.32 2132 546679409 ERL89880.1 1808 3.1e-199 hypothetical protein D910_07239 [Dendroctonus ponderosae] -- -- -- -- -- K01587 PAICS phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01587 Q9I7S8 1473 8.9e-162 Multifunctional protein ADE2 OS=Drosophila melanogaster GN=ade5 PE=2 SV=2 PF00763//PF00731 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//AIR carboxylase GO:0055114//GO:0046487//GO:0009396//GO:0006189 oxidation-reduction process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//'de novo' IMP biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase Cluster-8309.38245 BF_2 2527.76 27.02 4201 91092490 XP_968084.1 986 1.3e-103 PREDICTED: protein-L-isoaspartate O-methyltransferase domain-containing protein 1 [Tribolium castaneum]>gi|270012934|gb|EFA09382.1| hypothetical protein TcasGA2_TC001944 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R7K4 828 1.1e-86 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 OS=Pongo abelii GN=PCMTD2 PE=2 SV=1 PF08123//PF01135//PF08704//PF07525 Histone methylation protein DOT1//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//tRNA methyltransferase complex GCD14 subunit//SOCS box GO:0006464//GO:0030488//GO:0009451//GO:0006479//GO:0035556//GO:0006554//GO:0046500//GO:0008033 cellular protein modification process//tRNA methylation//RNA modification//protein methylation//intracellular signal transduction//lysine catabolic process//S-adenosylmethionine metabolic process//tRNA processing GO:0018024//GO:0016429//GO:0004719 histone-lysine N-methyltransferase activity//tRNA (adenine-N1-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0031515 tRNA (m1A) methyltransferase complex KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.38247 BF_2 20713.16 324.06 2961 642918282 XP_008191443.1 3855 0.0e+00 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X2 [Tribolium castaneum] 195430887 XM_002063444.1 411 0 Drosophila willistoni GK21381 (Dwil\GK21381), mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 3178 0.0e+00 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 PF13181//PF05009//PF13174//PF13371//PF13374//PF00515//PF02259//PF13176//PF13414 Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//FAT domain//Tetratricopeptide repeat//TPR repeat GO:0016032 viral process GO:0005515 protein binding GO:0042025 host cell nucleus KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.38248 BF_2 354.82 6.94 2426 91093505 XP_969151.1 2464 3.0e-275 PREDICTED: NADP-dependent malic enzyme [Tribolium castaneum]>gi|270002678|gb|EEZ99125.1| hypothetical protein TcasGA2_TC005232 [Tribolium castaneum] 194765020 XM_001964590.1 273 1.90514e-138 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1653 1.4e-182 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF01420//PF03949//PF00390 Type I restriction modification DNA specificity domain//Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006304//GO:0006108//GO:0055114//GO:0006090//GO:0006099//GO:0015976 DNA modification//malate metabolic process//oxidation-reduction process//pyruvate metabolic process//tricarboxylic acid cycle//carbon utilization GO:0051287//GO:0003677//GO:0046872//GO:0004471 NAD binding//DNA binding//metal ion binding//malate dehydrogenase (decarboxylating) (NAD+) activity -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.38249 BF_2 106.00 8.60 803 642923944 XP_008193936.1 224 5.5e-16 PREDICTED: flexible cuticle protein 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45589 157 1.3e-09 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF10584//PF00379 Proteasome subunit A N-terminal signature//Insect cuticle protein GO:0006511 ubiquitin-dependent protein catabolic process GO:0004175//GO:0042302 endopeptidase activity//structural constituent of cuticle GO:0019773 proteasome core complex, alpha-subunit complex -- -- Cluster-8309.38251 BF_2 925.40 8.54 4819 642914654 XP_008190301.1 1656 3.0e-181 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.84246e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.38252 BF_2 27.14 0.54 2403 642923425 XP_008193739.1 408 7.6e-37 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 199 5.4e-14 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38253 BF_2 959.03 34.74 1442 642923427 XP_008193740.1 1286 7.1e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 385 8.8e-36 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.38254 BF_2 1669.94 20.82 3643 91084273 XP_971218.1 3014 0.0e+00 PREDICTED: ATP-binding cassette sub-family D member 2 [Tribolium castaneum]>gi|270008750|gb|EFA05198.1| hypothetical protein TcasGA2_TC015333 [Tribolium castaneum] -- -- -- -- -- K05676 ABCD2, ALDL1 ATP-binding cassette, subfamily D (ALD), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05676 Q9UBJ2 1711 3.9e-189 ATP-binding cassette sub-family D member 2 OS=Homo sapiens GN=ABCD2 PE=1 SV=1 PF06472//PF00488//PF00005//PF07728//PF13304 ABC transporter transmembrane region 2//MutS domain V//ABC transporter//AAA domain (dynein-related subfamily)//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006200//GO:0006810//GO:0006298//GO:0055085 obsolete ATP catabolic process//transport//mismatch repair//transmembrane transport GO:0005524//GO:0042626//GO:0016887//GO:0030983 ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//mismatched DNA binding GO:0016021 integral component of membrane KOG0064 Peroxisomal long-chain acyl-CoA transporter, ABC superfamily Cluster-8309.38256 BF_2 37.69 0.52 3340 478255027 ENN75259.1 3164 0.0e+00 hypothetical protein YQE_08175, partial [Dendroctonus ponderosae]>gi|546673315|gb|ERL84943.1| hypothetical protein D910_02366 [Dendroctonus ponderosae] 749751938 XM_011139992.1 405 0 PREDICTED: Harpegnathos saltator regulator of nonsense transcripts 1 (LOC105182511), transcript variant X4, mRNA K14326 UPF1, RENT1 regulator of nonsense transcripts 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14326 Q9EPU0 2374 4.7e-266 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 PF07728//PF01443//PF00004//PF00437//PF00448//PF00580//PF04851//PF00270//PF05970 AAA domain (dynein-related subfamily)//Viral (Superfamily 1) RNA helicase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//UvrD/REP helicase N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//PIF1-like helicase GO:0000723//GO:0006614//GO:0006810//GO:0006281 telomere maintenance//SRP-dependent cotranslational protein targeting to membrane//transport//DNA repair GO:0005525//GO:0003676//GO:0016887//GO:0003678//GO:0005524//GO:0016787//GO:0003677 GTP binding//nucleic acid binding//ATPase activity//DNA helicase activity//ATP binding//hydrolase activity//DNA binding GO:0005657 replication fork KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.38257 BF_2 42.70 0.42 4580 642924646 XP_008194378.1 2585 5.3e-289 PREDICTED: tensin isoform X4 [Tribolium castaneum] -- -- -- -- -- K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 653 2.3e-66 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38258 BF_2 6930.75 197.25 1757 189234454 XP_967960.2 2117 3.8e-235 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11884 1726 3.4e-191 Aldehyde dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Aldh2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.38259 BF_2 321.16 2.42 5828 642917757 XP_008191356.1 425 2.0e-38 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 54 2.54372e-16 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.38262 BF_2 492.10 32.48 921 642921730 XP_008199303.1 710 2.8e-72 PREDICTED: methionine-R-sulfoxide reductase B1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07305 msrB peptide-methionine (R)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07305 Q8INK9 540 6.0e-54 Methionine-R-sulfoxide reductase B1 OS=Drosophila melanogaster GN=SelR PE=1 SV=3 PF01641 SelR domain GO:0055114 oxidation-reduction process GO:0033743 peptide-methionine (R)-S-oxide reductase activity -- -- KOG0856 Predicted pilin-like transcription factor Cluster-8309.38263 BF_2 177.59 1.93 4139 642924128 XP_008194017.1 5637 0.0e+00 PREDICTED: neural-cadherin isoform X2 [Tribolium castaneum] 642924137 XM_008195801.1 1157 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X7, mRNA -- -- -- -- O15943 4738 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF03222//PF00868//PF00028 Tryptophan/tyrosine permease family//Transglutaminase family//Cadherin domain GO:0003333//GO:0007156//GO:0018149 amino acid transmembrane transport//homophilic cell adhesion via plasma membrane adhesion molecules//peptide cross-linking GO:0005509 calcium ion binding GO:0016020 membrane KOG3594 FOG: Cadherin repeats Cluster-8309.38266 BF_2 884.62 4.57 8382 642934565 XP_008197717.1 3862 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF07714//PF06293//PF00069//PF01533 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Tospovirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0016772//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring phosphorus-containing groups//ATP binding GO:0019013//GO:0016020 viral nucleocapsid//membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.38267 BF_2 1581.69 56.71 1454 478264196 ENN82174.1 547 3.5e-53 hypothetical protein YQE_01450, partial [Dendroctonus ponderosae] 676480291 XM_009063766.1 40 3.77847e-09 Lottia gigantea hypothetical protein mRNA K07953 SAR1 GTP-binding protein SAR1 http://www.genome.jp/dbget-bin/www_bget?ko:K07953 Q9CQC9 437 8.2e-42 GTP-binding protein SAR1b OS=Mus musculus GN=Sar1b PE=1 SV=1 PF00071//PF04670//PF00025//PF00503//PF06858 Ras family//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//G-protein alpha subunit//Nucleolar GTP-binding protein 1 (NOG1) GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0031683//GO:0003924//GO:0005525//GO:0019001//GO:0004871 G-protein beta/gamma-subunit complex binding//GTPase activity//GTP binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0077 Vesicle coat complex COPII, GTPase subunit SAR1 Cluster-8309.38268 BF_2 41.00 1.20 1718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38269 BF_2 41.95 1.62 1372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38270 BF_2 17366.32 920.95 1076 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38271 BF_2 102.93 1.47 3211 642918017 XP_008198981.1 460 9.5e-43 PREDICTED: protein LSM14 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q566L7 195 2.1e-13 Protein LSM14 homolog B OS=Xenopus tropicalis GN=lsm14b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.38272 BF_2 88.38 1.96 2175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15048//PF13965 Organic solute transporter subunit beta protein//dsRNA-gated channel SID-1 GO:0015931//GO:0006810//GO:0015721//GO:0033227 nucleobase-containing compound transport//transport//bile acid and bile salt transport//dsRNA transport GO:0046982//GO:0005215//GO:0051033 protein heterodimerization activity//transporter activity//RNA transmembrane transporter activity GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.38273 BF_2 15.14 0.67 1235 646699403 KDR10033.1 215 9.4e-15 Chromobox protein-like protein 3 [Zootermopsis nevadensis] -- -- -- -- -- K11585 CBX1, HP1B, SWI6 chromobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11585 Q61686 191 2.3e-13 Chromobox protein homolog 5 OS=Mus musculus GN=Cbx5 PE=1 SV=1 PF12884//PF01393 Transducer of regulated CREB activity, N terminus//Chromo shadow domain GO:0051289 protein homotetramerization GO:0008140 cAMP response element binding protein binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1911 Heterochromatin-associated protein HP1 and related CHROMO domain proteins Cluster-8309.38274 BF_2 1422.01 9.23 6730 91082383 XP_968748.1 3389 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.06437e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2467 1.5e-276 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF02367//PF06414//PF01637//PF03266//PF03193//PF00005//PF00931//PF01580//PF01926//PF00158//PF13304//PF00664//PF02224//PF00437 Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Archaeal ATPase//NTPase//Protein of unknown function, DUF258//ABC transporter//NB-ARC domain//FtsK/SpoIIIE family//50S ribosome-binding GTPase//Sigma-54 interaction domain//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Cytidylate kinase//Type II/IV secretion system protein GO:0006355//GO:0006810//GO:0006139//GO:0055085//GO:0006206//GO:0002949 regulation of transcription, DNA-templated//transport//nucleobase-containing compound metabolic process//transmembrane transport//pyrimidine nucleobase metabolic process//tRNA threonylcarbamoyladenosine modification GO:0042626//GO:0016301//GO:0016887//GO:0004127//GO:0000166//GO:0003924//GO:0008134//GO:0098519//GO:0005524//GO:0017111//GO:0005525//GO:0043531//GO:0003677 ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//cytidylate kinase activity//nucleotide binding//GTPase activity//transcription factor binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//nucleoside-triphosphatase activity//GTP binding//ADP binding//DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.38276 BF_2 11.85 0.33 1800 642912323 XP_969456.2 1349 4.4e-146 PREDICTED: aldose reductase [Tribolium castaneum] 523485322 KC007347.1 74 5.90993e-28 Agrotis ipsilon clone Unigene_1274 aldo-keto reductase mRNA, partial cds K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 951 2.6e-101 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.38277 BF_2 4026.56 151.77 1397 478263077 ENN81477.1 931 1.0e-97 hypothetical protein YQE_02169, partial [Dendroctonus ponderosae]>gi|546682119|gb|ERL92100.1| hypothetical protein D910_09421 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38278 BF_2 4398.57 42.84 4582 478252433 ENN72856.1 1840 1.3e-202 hypothetical protein YQE_10505, partial [Dendroctonus ponderosae]>gi|478264876|gb|ENN82355.1| hypothetical protein YQE_01270, partial [Dendroctonus ponderosae] 157136696 XM_001656830.1 41 3.36457e-09 Aedes aegypti AAEL013617-RA partial mRNA -- -- -- -- P52757 903 2.4e-95 Beta-chimaerin OS=Homo sapiens GN=CHN2 PE=1 SV=2 PF01363//PF00620//PF04434//PF00130 FYVE zinc finger//RhoGAP domain//SWIM zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.38280 BF_2 380.03 3.91 4356 332373366 AEE61824.1 1272 9.0e-137 unknown [Dendroctonus ponderosae]>gi|478258142|gb|ENN78280.1| hypothetical protein YQE_05431, partial [Dendroctonus ponderosae] 391342831 XM_003745671.1 69 8.70302e-25 PREDICTED: Metaseiulus occidentalis GMP reductase 2-like (LOC100902322), mRNA K00364 E1.7.1.7, guaC GMP reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00364 Q9DCZ1 1150 5.2e-124 GMP reductase 1 OS=Mus musculus GN=Gmpr PE=2 SV=1 PF01070//PF01081//PF00478 FMN-dependent dehydrogenase//KDPG and KHG aldolase//IMP dehydrogenase / GMP reductase domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0016829//GO:0003824 oxidoreductase activity//lyase activity//catalytic activity -- -- KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.38281 BF_2 115.64 0.91 5625 91082383 XP_968748.1 3454 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2490 2.8e-279 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF16839//PF01926//PF13304//PF02714//PF00004//PF01637//PF02367//PF06414//PF00005//PF03193//PF00931 ABC transporter transmembrane region//Nematode antimicrobial peptide//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Calcium-dependent channel, 7TM region, putative phosphate//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//NB-ARC domain GO:0055085//GO:0006810//GO:0002949//GO:0098542 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification//defense response to other organism GO:0005524//GO:0003924//GO:0043531//GO:0016301//GO:0016887//GO:0005525//GO:0017111//GO:0042626 ATP binding//GTPase activity//ADP binding//kinase activity//ATPase activity//GTP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0016020 integral component of membrane//membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.38282 BF_2 639.33 7.14 4033 546676948 ERL87872.1 1851 6.1e-204 hypothetical protein D910_05260 [Dendroctonus ponderosae] -- -- -- -- -- K10416 DYNC1LI, DNCLI dynein light intermediate chain 1, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10416 O43237 1017 1.3e-108 Cytoplasmic dynein 1 light intermediate chain 2 OS=Homo sapiens GN=DYNC1LI2 PE=1 SV=1 PF08477//PF03193//PF00005//PF02892//PF00503//PF10662//PF13465 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ABC transporter//BED zinc finger//G-protein alpha subunit//Ethanolamine utilisation - propanediol utilisation//Zinc-finger double domain GO:0007264//GO:0007186//GO:0007165//GO:0006576 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction//cellular biogenic amine metabolic process GO:0046872//GO:0004871//GO:0016887//GO:0019001//GO:0005525//GO:0003924//GO:0003677//GO:0031683//GO:0005524 metal ion binding//signal transducer activity//ATPase activity//guanyl nucleotide binding//GTP binding//GTPase activity//DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding -- -- KOG2482 Predicted C2H2-type Zn-finger protein Cluster-8309.38283 BF_2 593.98 2.28 11178 642910658 XP_008200046.1 10447 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.38285 BF_2 420.00 12.45 1698 642910769 XP_008193402.1 1628 1.8e-178 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07926//PF10473 TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006606 protein import into nucleus GO:0042803//GO:0045502//GO:0008134 protein homodimerization activity//dynein binding//transcription factor binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.38286 BF_2 270.45 6.00 2173 91089699 XP_974834.1 1212 4.1e-130 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum]>gi|270011321|gb|EFA07769.1| hypothetical protein TcasGA2_TC005323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 173 5.1e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF00856//PF13414//PF08411 SET domain//TPR repeat//Exonuclease C-terminal GO:0006281//GO:0006308 DNA repair//DNA catabolic process GO:0008852//GO:0005515 exodeoxyribonuclease I activity//protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.38288 BF_2 172.00 14.06 799 642930971 XP_008196161.1 624 2.3e-62 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103313779 [Tribolium castaneum] -- -- -- -- -- K04650 NCOR1, N-CoR nuclear receptor co-repressor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38290 BF_2 269.64 1.32 8814 642918564 XP_008199298.1 1069 6.3e-113 PREDICTED: large proline-rich protein BAG6 isoform X2 [Tribolium castaneum] 242016373 XM_002428751.1 60 1.7802e-19 Pediculus humanus corporis RWD domain-containing protein, putative, mRNA -- -- -- -- A4IH17 240 3.5e-18 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF14560//PF00240//PF05773//PF07469 Ubiquitin-like domain//Ubiquitin family//RWD domain//Domain of unknown function (DUF1518) -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4018 Uncharacterized conserved protein, contains RWD domain Cluster-8309.38291 BF_2 23.57 0.81 1506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38292 BF_2 1558.42 34.90 2155 91089283 XP_970929.1 1290 3.6e-139 PREDICTED: protein phosphatase PTC7 homolog [Tribolium castaneum]>gi|270012497|gb|EFA08945.1| hypothetical protein TcasGA2_TC006652 [Tribolium castaneum] 768444891 XM_011566017.1 107 3.21051e-46 PREDICTED: Plutella xylostella protein phosphatase PTC7 homolog (LOC105394173), mRNA -- -- -- -- Q6GR25 678 1.4e-69 Protein phosphatase PTC7 homolog OS=Xenopus laevis GN=pptc7 PE=2 SV=1 PF07228//PF00481 Stage II sporulation protein E (SpoIIE)//Protein phosphatase 2C GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1379 Serine/threonine protein phosphatase Cluster-8309.38293 BF_2 759.29 25.37 1539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.38295 BF_2 192.78 2.18 3982 642924094 XP_008194003.1 2342 7.0e-261 PREDICTED: lysine--tRNA ligase isoform X1 [Tribolium castaneum] 157106532 XM_001649316.1 207 1.53662e-101 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1951 6.2e-217 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01336//PF01409//PF17121//PF00152 OB-fold nucleic acid binding domain//tRNA synthetases class II core domain (F)//Zinc finger, C3HC4 type (RING finger)//tRNA synthetases class II (D, K and N) GO:0043039//GO:0006418 tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0005515//GO:0005524//GO:0004812//GO:0003676//GO:0008270//GO:0000166 tRNA binding//protein binding//ATP binding//aminoacyl-tRNA ligase activity//nucleic acid binding//zinc ion binding//nucleotide binding GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.38296 BF_2 63.27 1.10 2683 546673028 ERL84714.1 2012 8.6e-223 hypothetical protein D910_02139 [Dendroctonus ponderosae] 826423471 XM_012671271.1 43 1.51447e-10 PREDICTED: Monomorium pharaonis putative inorganic phosphate cotransporter (LOC105831269), mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 946 1.4e-100 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38298 BF_2 153.37 0.73 9077 642923742 XP_966686.2 1948 7.7e-215 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X9 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O35547 1209 1.6e-130 Long-chain-fatty-acid--CoA ligase 4 OS=Rattus norvegicus GN=Acsl4 PE=1 SV=1 PF15138//PF00908//PF06624//PF09259//PF00501 Syncollin//dTDP-4-dehydrorhamnose 3,5-epimerase//Ribosome associated membrane protein RAMP4//Fungal immunomodulatory protein Fve//AMP-binding enzyme GO:0006887//GO:0002682//GO:0030639//GO:0019872//GO:0008152//GO:0009117 exocytosis//regulation of immune system process//polyketide biosynthetic process//streptomycin biosynthetic process//metabolic process//nucleotide metabolic process GO:0030246//GO:0008830//GO:0003824 carbohydrate binding//dTDP-4-dehydrorhamnose 3,5-epimerase activity//catalytic activity GO:0030667//GO:0005783 secretory granule membrane//endoplasmic reticulum KOG1180 Acyl-CoA synthetase Cluster-8309.38299 BF_2 2299.34 52.39 2123 642911450 XP_973171.3 2475 1.4e-276 PREDICTED: cullin-associated NEDD8-dissociated protein 1 [Tribolium castaneum]>gi|270014883|gb|EFA11331.1| hypothetical protein TcasGA2_TC010870 [Tribolium castaneum] -- -- -- -- -- K17263 CAND1 cullin-associated NEDD8-dissociated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17263 A7MBJ5 2026 6.7e-226 Cullin-associated NEDD8-dissociated protein 1 OS=Bos taurus GN=CAND1 PE=2 SV=1 PF02985//PF08064//PF00790//PF07062//PF01602//PF07571 HEAT repeat//UME (NUC010) domain//VHS domain//Clc-like//Adaptin N terminal region//TAF6 C-terminal HEAT repeat domain GO:0009069//GO:0051090//GO:0016310//GO:0006886//GO:0016192 serine family amino acid metabolic process//regulation of sequence-specific DNA binding transcription factor activity//phosphorylation//intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0004674 protein binding//protein serine/threonine kinase activity GO:0005634//GO:0016021//GO:0030117 nucleus//integral component of membrane//membrane coat KOG1824 TATA-binding protein-interacting protein Cluster-8309.38301 BF_2 1075.67 17.61 2842 642925507 XP_008194579.1 1970 6.8e-218 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.42634e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 P47820 1312 5.6e-143 Angiotensin-converting enzyme OS=Rattus norvegicus GN=Ace PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.38302 BF_2 2422.05 40.50 2789 642925507 XP_008194579.1 1970 6.7e-218 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum]>gi|270008859|gb|EFA05307.1| hypothetical protein TcasGA2_TC015465 [Tribolium castaneum] 667266609 XM_008571155.1 55 3.36163e-17 PREDICTED: Galeopterus variegatus angiotensin I converting enzyme (ACE), partial mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q10751 1312 5.5e-143 Angiotensin-converting enzyme (Fragment) OS=Gallus gallus GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.38303 BF_2 38.53 0.70 2596 91088273 XP_967838.1 482 2.2e-45 PREDICTED: protein scylla [Tribolium castaneum]>gi|270012158|gb|EFA08606.1| hypothetical protein TcasGA2_TC006266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTH4 254 2.4e-20 Protein scylla OS=Drosophila melanogaster GN=scyl PE=2 SV=1 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.38304 BF_2 94.00 2.38 1942 546681034 ERL91199.1 388 1.3e-34 hypothetical protein D910_08538 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38305 BF_2 717.27 7.82 4122 390198528 AFL70631.1 1230 6.3e-132 putative hypoxia-inducible factor 1 alpha [Callosobruchus maculatus] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 -- -- -- -- PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38306 BF_2 71.81 0.37 8431 612027814 XP_007492786.1 362 5.8e-31 PREDICTED: zinc finger protein 208-like, partial [Monodelphis domestica] -- -- -- -- -- -- -- -- -- Q96NI8 342 5.0e-30 Zinc finger protein 570 OS=Homo sapiens GN=ZNF570 PE=2 SV=1 PF00508//PF00096//PF13465//PF09606//PF08452//PF02724//PF13912 E2 (early) protein, N terminal//Zinc finger, C2H2 type//Zinc-finger double domain//ARC105 or Med15 subunit of Mediator complex non-fungal//DNA polymerase family B exonuclease domain, N-terminal//CDC45-like protein//C2H2-type zinc finger GO:0006355//GO:0006357//GO:0006260//GO:0006275//GO:0016032//GO:0006270 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//DNA replication//regulation of DNA replication//viral process//DNA replication initiation GO:0046872//GO:0001104//GO:0003887 metal ion binding//RNA polymerase II transcription cofactor activity//DNA-directed DNA polymerase activity GO:0016592//GO:0042575 mediator complex//DNA polymerase complex -- -- Cluster-8309.38308 BF_2 389.73 1.81 9309 478251011 ENN71492.1 1206 8.7e-129 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q9GZT9 668 8.7e-68 Egl nine homolog 1 OS=Homo sapiens GN=EGLN1 PE=1 SV=1 PF01254//PF13640 Nuclear transition protein 2//2OG-Fe(II) oxygenase superfamily GO:0007283//GO:0055114 spermatogenesis//oxidation-reduction process GO:0016491//GO:0003677 oxidoreductase activity//DNA binding GO:0000786//GO:0005634 nucleosome//nucleus KOG3710 EGL-Nine (EGLN) protein Cluster-8309.38310 BF_2 111.00 1.58 3221 270015796 EFA12244.1 1314 9.0e-142 hypothetical protein TcasGA2_TC005276 [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q7T3E6 302 8.2e-26 Polycomb complex protein BMI-1-B OS=Danio rerio GN=bmi1b PE=2 SV=1 PF00097//PF17121//PF12678//PF12861//PF14634//PF13639//PF11789 Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Ring finger domain//Zinc-finger of the MIZ type in Nse subunit GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.38311 BF_2 52.73 1.05 2390 478251374 ENN71840.1 586 1.7e-57 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 77 1.69488e-29 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 411 1.4e-38 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF04869//PF00171 Uso1 / p115 like vesicle tethering protein, head region//Aldehyde dehydrogenase family GO:0008152//GO:0055114//GO:0006886//GO:0048280 metabolic process//oxidation-reduction process//intracellular protein transport//vesicle fusion with Golgi apparatus GO:0016491 oxidoreductase activity GO:0000139//GO:0005737 Golgi membrane//cytoplasm KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.38312 BF_2 329.84 14.63 1230 674304042 AIL23552.1 751 6.6e-77 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q2NL00 415 2.5e-39 Glutathione S-transferase theta-1 OS=Bos taurus GN=GSTT1 PE=2 SV=3 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG0867 Glutathione S-transferase Cluster-8309.38313 BF_2 104.27 0.96 4827 270004647 EFA01095.1 988 8.5e-104 hypothetical protein TcasGA2_TC004018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWG4 220 4.0e-16 Uncharacterized protein KIAA1755 homolog OS=Mus musculus PE=2 SV=2 PF01708//PF16099 Geminivirus putative movement protein//Recq-mediated genome instability protein 1, C-terminal OB-fold GO:0046740 transport of virus in host, cell to cell GO:0000166 nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.38314 BF_2 126.77 0.79 6996 91084043 XP_967085.1 1345 5.0e-145 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 157 1.68914e-73 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1123 1.1e-120 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF10415//PF00491//PF01607//PF01029//PF01336 Fumarase C C-terminus//Arginase family//Chitin binding Peritrophin-A domain//NusB family//OB-fold nucleic acid binding domain GO:0006030//GO:0019643//GO:0006355//GO:0006099//GO:0006106 chitin metabolic process//reductive tricarboxylic acid cycle//regulation of transcription, DNA-templated//tricarboxylic acid cycle//fumarate metabolic process GO:0003723//GO:0003676//GO:0016829//GO:0046872//GO:0004333//GO:0008061 RNA binding//nucleic acid binding//lyase activity//metal ion binding//fumarate hydratase activity//chitin binding GO:0005576//GO:0045239 extracellular region//tricarboxylic acid cycle enzyme complex KOG1317 Fumarase Cluster-8309.38315 BF_2 8454.58 138.60 2839 642932670 XP_008196939.1 401 5.9e-36 PREDICTED: BAG domain-containing protein Samui isoform X2 [Tribolium castaneum] -- -- -- -- -- K09558 BAG4 BCL2-associated athanogene 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09558 Q9BLJ6 306 2.5e-26 BAG domain-containing protein Samui OS=Bombyx mori GN=Samui PE=2 SV=1 PF02179 BAG domain -- -- GO:0051087 chaperone binding -- -- KOG4361 BCL2-associated athanogene-like proteins and related BAG family chaperone regulators Cluster-8309.38317 BF_2 885.00 28.37 1592 91079450 XP_969249.1 1849 4.1e-204 PREDICTED: venom serine carboxypeptidase [Tribolium castaneum]>gi|270016070|gb|EFA12518.1| hypothetical protein TcasGA2_TC002692 [Tribolium castaneum] -- -- -- -- -- K09645 CPVL vitellogenic carboxypeptidase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K09645 C9WMM5 1403 8.7e-154 Venom serine carboxypeptidase OS=Apis mellifera PE=2 SV=1 PF00450//PF06971 Serine carboxypeptidase//Putative DNA-binding protein N-terminus GO:0006508//GO:0045892//GO:0051775 proteolysis//negative regulation of transcription, DNA-templated//response to redox state GO:0004185 serine-type carboxypeptidase activity GO:0005737 cytoplasm KOG1282 Serine carboxypeptidases (lysosomal cathepsin A) Cluster-8309.38318 BF_2 75.18 0.44 7515 642918059 XP_008193846.1 6483 0.0e+00 PREDICTED: nucleoprotein TPR isoform X1 [Tribolium castaneum] -- -- -- -- -- K09291 TPR, MLP1, MLP2 nucleoprotein TPR http://www.genome.jp/dbget-bin/www_bget?ko:K09291 A1Z8P9 2086 2.6e-232 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07544//PF05294//PF06005//PF02186//PF07926 RNA polymerase II transcription mediator complex subunit 9//Scorpion short toxin//Protein of unknown function (DUF904)//TFIIE beta subunit core domain//TPR/MLP1/MLP2-like protein GO:0006606//GO:0006357//GO:0006367//GO:0000917//GO:0043093//GO:0009405 protein import into nucleus//regulation of transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//barrier septum assembly//FtsZ-dependent cytokinesis//pathogenesis GO:0001104 RNA polymerase II transcription cofactor activity GO:0005576//GO:0005737//GO:0016592 extracellular region//cytoplasm//mediator complex KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.38319 BF_2 472.28 9.23 2427 642938988 XP_008200105.1 1045 1.1e-110 PREDICTED: serine protease inhibitor 3/4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 586 7.3e-59 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38320 BF_2 1586.94 38.71 2002 642938992 XP_008200107.1 1023 3.1e-108 PREDICTED: serine protease inhibitor 3/4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 569 5.6e-57 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38321 BF_2 847.18 16.12 2485 642938996 XP_008200109.1 1041 3.1e-110 PREDICTED: serine protease inhibitor 3/4-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 579 4.8e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38322 BF_2 689.84 16.62 2024 642926804 XP_008195020.1 1258 1.8e-135 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 3.01213e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q9XWU8 782 1.1e-81 Ectopic P granules protein 3 OS=Caenorhabditis elegans GN=epg-3 PE=2 SV=2 PF01741//PF00323 Large-conductance mechanosensitive channel, MscL//Mammalian defensin GO:0006952//GO:0006811//GO:0006810 defense response//ion transport//transport GO:0005216 ion channel activity GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.38323 BF_2 327.84 5.80 2651 642938996 XP_008200109.1 1050 3.0e-111 PREDICTED: serine protease inhibitor 3/4-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 579 5.1e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38326 BF_2 855.00 9.33 4122 642935064 XP_008199925.1 275 3.5e-21 PREDICTED: nesprin-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38327 BF_2 354.00 11.89 1533 270014128 EFA10576.1 288 4.0e-23 hypothetical protein TcasGA2_TC012832 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NVR1 176 1.6e-11 Alpha-endosulfine OS=Xenopus tropicalis GN=ensa PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4076 Regulator of ATP-sensitive K+ channels Alpha-endosulfine/ARPP-19 and related cAMP-regulated phosphoproteins Cluster-8309.38328 BF_2 12064.30 123.16 4385 646720852 KDR22435.1 6023 0.0e+00 Clathrin heavy chain [Zootermopsis nevadensis] 347969081 XM_003436308.1 2014 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 5834 0.0e+00 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF01736//PF00231//PF09268//PF00515//PF04053//PF00637//PF13176//PF12937 Polyomavirus agnoprotein//ATP synthase//Clathrin, heavy-chain linker//Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS//Tetratricopeptide repeat//F-box-like GO:0006119//GO:0006886//GO:0016192//GO:0015986//GO:0015992 oxidative phosphorylation//intracellular protein transport//vesicle-mediated transport//ATP synthesis coupled proton transport//proton transport GO:0003677//GO:0005198//GO:0005515//GO:0046933//GO:0046961 DNA binding//structural molecule activity//protein binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0030132//GO:0045261//GO:0045259//GO:0030130//GO:0030117 clathrin coat of coated pit//proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex//clathrin coat of trans-Golgi network vesicle//membrane coat KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.38329 BF_2 117.79 1.18 4449 568253675 ETN62753.1 4297 0.0e+00 clathrin heavy chain [Anopheles darlingi] 347969081 XM_003436308.1 1421 0 Anopheles gambiae str. PEST AGAP003021-PB (AgaP_AGAP003021) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 4162 0.0e+00 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF01736//PF00515//PF04053//PF00637//PF13176//PF12937//PF00231 Polyomavirus agnoprotein//Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS//Tetratricopeptide repeat//F-box-like//ATP synthase GO:0015992//GO:0015986//GO:0006886//GO:0016192//GO:0006119 proton transport//ATP synthesis coupled proton transport//intracellular protein transport//vesicle-mediated transport//oxidative phosphorylation GO:0046961//GO:0046933//GO:0005515//GO:0005198//GO:0003677 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//protein binding//structural molecule activity//DNA binding GO:0030117//GO:0045259//GO:0045261 membrane coat//proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.38330 BF_2 4547.84 45.08 4507 642934408 XP_008197648.1 2058 6.7e-228 PREDICTED: transport and Golgi organization protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VMA7 461 4.2e-44 Transport and Golgi organization protein 1 OS=Drosophila melanogaster GN=Tango1 PE=1 SV=2 PF05791//PF00734//PF00038 Bacillus haemolytic enterotoxin (HBL)//Fungal cellulose binding domain//Intermediate filament protein GO:0009405//GO:0005975 pathogenesis//carbohydrate metabolic process GO:0030248//GO:0004553//GO:0005198 cellulose binding//hydrolase activity, hydrolyzing O-glycosyl compounds//structural molecule activity GO:0005882//GO:0005576//GO:0016020 intermediate filament//extracellular region//membrane -- -- Cluster-8309.38331 BF_2 193.42 2.69 3299 642932518 XP_008197147.1 2554 1.5e-285 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X3 [Tribolium castaneum] 642932517 XM_008198925.1 575 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 2078 9.7e-232 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 PF17082//PF00069//PF07714 Spindle Pole Component 29//Protein kinase domain//Protein tyrosine kinase GO:0030474//GO:0006468 spindle pole body duplication//protein phosphorylation GO:0005524//GO:0005200//GO:0004672 ATP binding//structural constituent of cytoskeleton//protein kinase activity GO:0005856//GO:0005823 cytoskeleton//central plaque of spindle pole body KOG0614 cGMP-dependent protein kinase Cluster-8309.38333 BF_2 729.90 6.95 4679 270008875 EFA05323.1 1281 8.8e-138 hypothetical protein TcasGA2_TC015481 [Tribolium castaneum] 110431373 NM_001042570.1 306 1.67267e-156 Tribolium castaneum chitinase 7 (Cht7), mRNA >gnl|BL_ORD_ID|3159255 Tribolium castaneum chitinase 7 mRNA, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 491 1.5e-47 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF01607//PF00704 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18 GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.38334 BF_2 2128.32 118.90 1036 642925814 XP_970128.3 541 1.2e-52 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 370 3.5e-34 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- -- -- Cluster-8309.38335 BF_2 515.93 2.52 8859 642930846 XP_008196111.1 677 1.8e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38338 BF_2 2230.12 23.47 4262 91080099 XP_966636.1 490 4.2e-46 PREDICTED: tumor protein p53-inducible nuclear protein 2 [Tribolium castaneum]>gi|270004657|gb|EFA01105.1| hypothetical protein TcasGA2_TC004030 [Tribolium castaneum] 642918603 XM_961543.3 73 5.08777e-27 PREDICTED: Tribolium castaneum tumor protein p53-inducible nuclear protein 2 (LOC655048), mRNA K15310 TP53INP1 tumor protein p53-inducible nuclear protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15310 Q9QXE4 193 4.8e-13 Tumor protein p53-inducible nuclear protein 1 OS=Mus musculus GN=Trp53inp1 PE=2 SV=1 PF10034 Q-cell neuroblast polarisation -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38339 BF_2 82.10 0.56 6367 642918882 XP_008191626.1 1989 9.5e-220 PREDICTED: E3 ubiquitin-protein ligase TRIM33-like [Tribolium castaneum] 817217743 XM_012429361.1 488 0 PREDICTED: Orussus abietinus serine/threonine-protein kinase minibrain (LOC105702083), transcript variant X2, mRNA K08825 DYRK1 dual specificity tyrosine-phosphorylation-regulated kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08825 P49657 1840 7.4e-204 Serine/threonine-protein kinase minibrain OS=Drosophila melanogaster GN=mnb PE=2 SV=2 PF06180//PF07714//PF00069//PF01399 Cobalt chelatase (CbiK)//Protein tyrosine kinase//Protein kinase domain//PCI domain GO:0019251//GO:0006783//GO:0006468 anaerobic cobalamin biosynthetic process//heme biosynthetic process//protein phosphorylation GO:0005524//GO:0004672//GO:0005515//GO:0016852 ATP binding//protein kinase activity//protein binding//sirohydrochlorin cobaltochelatase activity -- -- KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.38340 BF_2 4260.00 68.05 2906 546676886 ERL87810.1 2010 1.6e-222 hypothetical protein D910_05199 [Dendroctonus ponderosae] -- -- -- -- -- K07611 LMNB lamin B http://www.genome.jp/dbget-bin/www_bget?ko:K07611 P08928 1438 1.4e-157 Lamin Dm0 OS=Drosophila melanogaster GN=Lam PE=1 SV=4 PF00038//PF05478 Intermediate filament protein//Prominin -- -- GO:0005198 structural molecule activity GO:0016021//GO:0005882 integral component of membrane//intermediate filament KOG0977 Nuclear envelope protein lamin, intermediate filament superfamily Cluster-8309.38341 BF_2 857.00 28.73 1535 226968614 YP_002808563.1 1895 1.8e-209 cytochrome c oxidase subunit I [Scylla paramamosain]>gi|225697850|gb|ACO07217.1| cytochrome c oxidase subunit I [Scylla paramamosain]>gi|403311089|gb|AFR34048.1| cytochrome c oxidase subunit I (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 1509 0 Scylla paramamosain mitochondrion, complete genome K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P00399 1669 1.2e-184 Cytochrome c oxidase subunit 1 OS=Drosophila melanogaster GN=mt:CoI PE=2 SV=2 -- -- GO:0006118//GO:0022900//GO:0015992//GO:0006123//GO:0009060//GO:0006119 obsolete electron transport//electron transport chain//proton transport//mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration//oxidative phosphorylation GO:0009055//GO:0020037//GO:0004129//GO:0005506 electron carrier activity//heme binding//cytochrome-c oxidase activity//iron ion binding GO:0016021//GO:0070469//GO:0005743//GO:0045277 integral component of membrane//respiratory chain//mitochondrial inner membrane//respiratory chain complex IV KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.38342 BF_2 993.46 30.47 1651 642915524 XP_008190651.1 1664 1.2e-182 PREDICTED: transmembrane protein 184B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VDL9 1125 1.6e-121 Transmembrane protein 184B OS=Bos taurus GN=TMEM184B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.38343 BF_2 9406.35 74.18 5592 642910328 XP_008200285.1 3191 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270014917|gb|EFA11365.1| hypothetical protein TcasGA2_TC011522 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1941 1.3e-215 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00975//PF00106//PF00107 Thioesterase domain//short chain dehydrogenase//Zinc-binding dehydrogenase GO:0055114//GO:0009058//GO:0008152//GO:0006633//GO:0042967 oxidation-reduction process//biosynthetic process//metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016297//GO:0016788//GO:0016491 acyl-[acyl-carrier-protein] hydrolase activity//hydrolase activity, acting on ester bonds//oxidoreductase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.38344 BF_2 765.86 4.89 6838 642916281 XP_008190958.1 3513 0.0e+00 PREDICTED: NFX1-type zinc finger-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R151 1145 3.1e-123 NFX1-type zinc finger-containing protein 1 OS=Mus musculus GN=Znfx1 PE=2 SV=3 PF00270//PF00769//PF07926//PF04851//PF09726//PF02562//PF01920//PF00004//PF00170//PF07728//PF01695//PF04977 DEAD/DEAH box helicase//Ezrin/radixin/moesin family//TPR/MLP1/MLP2-like protein//Type III restriction enzyme, res subunit//Transmembrane protein//PhoH-like protein//Prefoldin subunit//ATPase family associated with various cellular activities (AAA)//bZIP transcription factor//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Septum formation initiator GO:0007049//GO:0006606//GO:0006355//GO:0006457 cell cycle//protein import into nucleus//regulation of transcription, DNA-templated//protein folding GO:0016787//GO:0005524//GO:0003700//GO:0016887//GO:0043565//GO:0051082//GO:0003677//GO:0008092//GO:0003676 hydrolase activity//ATP binding//transcription factor activity, sequence-specific DNA binding//ATPase activity//sequence-specific DNA binding//unfolded protein binding//DNA binding//cytoskeletal protein binding//nucleic acid binding GO:0019898//GO:0016021//GO:0005737//GO:0016272//GO:0005667 extrinsic component of membrane//integral component of membrane//cytoplasm//prefoldin complex//transcription factor complex KOG1807 Helicases Cluster-8309.38346 BF_2 98.73 1.17 3817 642937750 XP_008198931.1 1242 2.4e-133 PREDICTED: GRAM domain-containing protein 3-like isoform X3 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.30196e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q3KR37 272 2.9e-22 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 PF01277 Oleosin -- -- -- -- GO:0016021//GO:0012511 integral component of membrane//monolayer-surrounded lipid storage body KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.38348 BF_2 3951.23 371.56 732 557798908 AHA36969.1 920 9.9e-97 heat shock protein 70b [Leptinotarsa decemlineata] 850325561 XM_004716450.2 134 1.03517e-61 PREDICTED: Echinops telfairi heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) (HSPA5), mRNA K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 P29844 854 1.8e-90 Heat shock 70 kDa protein cognate 3 OS=Drosophila melanogaster GN=Hsc70-3 PE=2 SV=2 PF06723//PF01791 MreB/Mbl protein//DeoC/LacD family aldolase GO:0000902 cell morphogenesis GO:0016829 lyase activity -- -- KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-8309.38349 BF_2 68.71 0.82 3777 270014227 EFA10675.1 3301 0.0e+00 kinesin heavy chain [Tribolium castaneum] 642936643 XM_008200299.1 791 0 PREDICTED: Tribolium castaneum kinesin 1 (LOC662208), mRNA K10396 KIF5 kinesin family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10396 P17210 2745 5.0e-309 Kinesin heavy chain OS=Drosophila melanogaster GN=Khc PE=1 SV=2 PF04111//PF01601//PF00225//PF05557//PF00769//PF08702//PF15461 Autophagy protein Apg6//Coronavirus S2 glycoprotein//Kinesin motor domain//Mitotic checkpoint protein//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Beta-carotene 15,15'-dioxygenase GO:0007165//GO:0007018//GO:0051258//GO:0006914//GO:0007017//GO:0055114//GO:0030168//GO:0061025//GO:0007094//GO:0046813 signal transduction//microtubule-based movement//protein polymerization//autophagy//microtubule-based process//oxidation-reduction process//platelet activation//membrane fusion//mitotic spindle assembly checkpoint//receptor-mediated virion attachment to host cell GO:0005524//GO:0016702//GO:0005102//GO:0008092//GO:0003777//GO:0008017//GO:0030674 ATP binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//receptor binding//cytoskeletal protein binding//microtubule motor activity//microtubule binding//protein binding, bridging GO:0016021//GO:0019898//GO:0045298//GO:0005737//GO:0005577//GO:0019031//GO:0005874 integral component of membrane//extrinsic component of membrane//tubulin complex//cytoplasm//fibrinogen complex//viral envelope//microtubule KOG0240 Kinesin (SMY1 subfamily) Cluster-8309.38351 BF_2 104.34 1.16 4034 270010524 EFA06972.1 1110 5.1e-118 hypothetical protein TcasGA2_TC009932 [Tribolium castaneum] -- -- -- -- -- K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 Q9NZI7 662 1.9e-67 Upstream-binding protein 1 OS=Homo sapiens GN=UBP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.38352 BF_2 288.00 7.90 1813 91080577 XP_973491.1 1825 2.8e-201 PREDICTED: transmembrane protein 87A [Tribolium castaneum]>gi|642919365|ref|XP_008191841.1| PREDICTED: transmembrane protein 87A [Tribolium castaneum]>gi|642919367|ref|XP_008191842.1| PREDICTED: transmembrane protein 87A [Tribolium castaneum]>gi|270005808|gb|EFA02256.1| hypothetical protein TcasGA2_TC007919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28EW0 981 8.5e-105 Transmembrane protein 87A OS=Xenopus tropicalis GN=tmem87a PE=2 SV=1 PF06814 Lung seven transmembrane receptor -- -- -- -- GO:0016021 integral component of membrane KOG2568 Predicted membrane protein Cluster-8309.38353 BF_2 182.36 1.74 4674 642928151 XP_008200178.1 3675 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 1A isoform X1 [Tribolium castaneum] -- -- -- -- -- K11655 BAZ1A, ACF1 bromodomain adjacent to zinc finger domain protein 1A http://www.genome.jp/dbget-bin/www_bget?ko:K11655 Q9NRL2 535 1.1e-52 Bromodomain adjacent to zinc finger domain protein 1A OS=Homo sapiens GN=BAZ1A PE=1 SV=2 PF00439//PF00628 Bromodomain//PHD-finger -- -- GO:0005515 protein binding -- -- KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.38354 BF_2 615.81 9.80 2917 91091412 XP_973980.1 497 4.4e-47 PREDICTED: cAMP-responsive element-binding protein-like 2 [Tribolium castaneum]>gi|270014172|gb|EFA10620.1| hypothetical protein TcasGA2_TC012882 [Tribolium castaneum] 751781411 XM_011201569.1 47 9.85058e-13 PREDICTED: Bactrocera dorsalis cAMP-responsive element-binding protein-like 2 (LOC105223754), mRNA -- -- -- -- A4IGK3 291 1.4e-24 cAMP-responsive element-binding protein-like 2 OS=Xenopus tropicalis GN=crebl2 PE=3 SV=1 PF01694//PF00170//PF07716 Rhomboid family//bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0004252 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG2289 Rhomboid family proteins Cluster-8309.38357 BF_2 1452.37 4.59 13511 478258629 ENN78679.1 7005 0.0e+00 hypothetical protein YQE_04851, partial [Dendroctonus ponderosae]>gi|546685785|gb|ERL95234.1| hypothetical protein D910_12501 [Dendroctonus ponderosae] 665784642 XM_008562939.1 64 1.63317e-21 PREDICTED: Microplitis demolitor synaptobrevin homolog YKT6 (LOC103580980), mRNA K05732 GRLF1 glucocorticoid receptor DNA-binding factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05732 Q9VX32 2839 0.0e+00 Rho GTPase-activating protein 190 OS=Drosophila melanogaster GN=RhoGAPp190 PE=1 SV=2 PF00620//PF00957//PF00642//PF08911//PF00071//PF10403//PF01207 RhoGAP domain//Synaptobrevin//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//NUP50 (Nucleoporin 50 kDa)//Ras family//Rad4 beta-hairpin domain 1//Dihydrouridine synthase (Dus) GO:0008033//GO:0055114//GO:0007264//GO:0016192//GO:0007165 tRNA processing//oxidation-reduction process//small GTPase mediated signal transduction//vesicle-mediated transport//signal transduction GO:0046872//GO:0050660//GO:0005525//GO:0017150//GO:0003677 metal ion binding//flavin adenine dinucleotide binding//GTP binding//tRNA dihydrouridine synthase activity//DNA binding GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG2333 Uncharacterized conserved protein Cluster-8309.38358 BF_2 3935.43 364.35 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38359 BF_2 279.02 5.29 2492 642927244 XP_974103.2 1078 1.6e-114 PREDICTED: stromal membrane-associated protein 1-like [Tribolium castaneum] -- -- -- -- -- K12486 SMAP stromal membrane-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K12486 Q5EA00 525 8.8e-52 Stromal membrane-associated protein 2 OS=Bos taurus GN=SMAP2 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.38360 BF_2 9029.73 488.13 1061 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38361 BF_2 216.03 4.12 2481 642927244 XP_974103.2 1078 1.6e-114 PREDICTED: stromal membrane-associated protein 1-like [Tribolium castaneum] -- -- -- -- -- K12486 SMAP stromal membrane-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K12486 Q5EA00 525 8.8e-52 Stromal membrane-associated protein 2 OS=Bos taurus GN=SMAP2 PE=2 SV=1 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.38362 BF_2 3912.16 116.74 1689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38364 BF_2 135.95 4.33 1600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38365 BF_2 134.89 1.44 4195 642931877 XP_008196766.1 291 4.9e-23 PREDICTED: casein kinase I isoform delta-A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38366 BF_2 122.58 1.16 4689 642926472 XP_008191972.1 1172 3.8e-125 PREDICTED: flotillin-2 isoform X2 [Tribolium castaneum]>gi|642926474|ref|XP_008191973.1| PREDICTED: flotillin-2 isoform X2 [Tribolium castaneum] 645037638 XM_008207769.1 245 1.36163e-122 PREDICTED: Nasonia vitripennis flotillin-2 (LOC103316081), mRNA K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61492 1067 2.4e-114 Flotillin-2 OS=Drosophila melanogaster GN=Flo-2 PE=2 SV=3 PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005245 voltage-gated calcium channel activity GO:0005891 voltage-gated calcium channel complex -- -- Cluster-8309.38367 BF_2 770.16 4.81 6992 642931879 XP_972641.2 1968 2.9e-217 PREDICTED: casein kinase I isoform delta-A isoform X2 [Tribolium castaneum] 642931878 XM_967548.3 364 0 PREDICTED: Tribolium castaneum casein kinase I isoform delta-A (LOC661388), transcript variant X2, mRNA K08959 CSNK1D casein kinase 1, delta http://www.genome.jp/dbget-bin/www_bget?ko:K08959 Q9DC28 1532 4.2e-168 Casein kinase I isoform delta OS=Mus musculus GN=Csnk1d PE=1 SV=2 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.38368 BF_2 2637.36 60.72 2104 332374576 AEE62429.1 1425 7.9e-155 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] 194899597 XM_001979310.1 284 1.26544e-144 Drosophila erecta GG24321 (Dere\GG24321), mRNA K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 1286 4.3e-140 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- -- -- Cluster-8309.38369 BF_2 17.81 0.66 1411 332372610 AEE61447.1 485 5.3e-46 unknown [Dendroctonus ponderosae]>gi|478266066|gb|ENN82675.1| hypothetical protein YQE_00959, partial [Dendroctonus ponderosae]>gi|546679096|gb|ERL89609.1| hypothetical protein D910_06974 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96CX6 326 6.0e-29 Leucine-rich repeat-containing protein 58 OS=Homo sapiens GN=LRRC58 PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.38370 BF_2 9389.99 251.82 1847 195341714 XP_002037451.1 218 6.3e-15 GM12097 [Drosophila sechellia]>gi|194131567|gb|EDW53610.1| GM12097 [Drosophila sechellia]>gi|900917488|gb|KMZ06990.1| uncharacterized protein Dsimw501_GD16524, isoform B [Drosophila simulans]>gi|900917489|gb|KMZ06991.1| uncharacterized protein Dsimw501_GD16524, isoform C [Drosophila simulans]>gi|900917490|gb|KMZ06992.1| uncharacterized protein Dsimw501_GD16524, isoform D [Drosophila simulans]>gi|900917491|gb|KMZ06993.1| uncharacterized protein Dsimw501_GD16524, isoform E [Drosophila simulans] 642937681 XM_008200677.1 165 1.57172e-78 PREDICTED: Tribolium castaneum ATP synthase lipid-binding protein, mitochondrial (LOC655995), transcript variant X2, mRNA K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 P07926 204 1.1e-14 ATP synthase F(0) complex subunit C2, mitochondrial OS=Bos taurus GN=ATP5G2 PE=1 SV=1 PF00137//PF02703 ATP synthase subunit C//Early E1A protein GO:0015992//GO:0006810//GO:0015991//GO:0019048//GO:0006355 proton transport//transport//ATP hydrolysis coupled proton transport//modulation by virus of host morphology or physiology//regulation of transcription, DNA-templated GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.38371 BF_2 3340.61 35.76 4195 646701001 KDR10924.1 2056 1.1e-227 ATP-dependent RNA helicase DDX3X [Zootermopsis nevadensis] 237681148 NM_001160249.1 491 0 Tribolium castaneum ATP-dependent RNA helicase belle (belle), mRNA K11594 DDX3X, bel ATP-dependent RNA helicase DDX3X http://www.genome.jp/dbget-bin/www_bget?ko:K11594 Q9VHP0 1729 3.6e-191 ATP-dependent RNA helicase bel OS=Drosophila melanogaster GN=bel PE=1 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003676//GO:0016787//GO:0003677 ATP binding//nucleic acid binding//hydrolase activity//DNA binding -- -- KOG0335 ATP-dependent RNA helicase Cluster-8309.38372 BF_2 22.34 0.56 1947 642918472 XP_971273.2 1504 5.0e-164 PREDICTED: protein NDRG3 isoform X3 [Tribolium castaneum] 462464055 APGK01005064.1 69 3.8531e-25 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 1.9e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.38373 BF_2 185.27 15.47 788 332374846 AEE62564.1 346 3.9e-30 unknown [Dendroctonus ponderosae] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 252 1.3e-20 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106//PF01073//PF01370 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0008152//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016491//GO:0016616//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.38375 BF_2 251.30 2.44 4596 189235544 XP_001814869.1 1907 2.2e-210 PREDICTED: actin-related protein 2 [Tribolium castaneum]>gi|270003115|gb|EEZ99562.1| hypothetical protein TcasGA2_TC000144 [Tribolium castaneum] 605059338 KJ187399.1 303 7.64307e-155 Spodoptera frugiperda actin-related protein Arp2 (ARP2) mRNA, partial cds K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 P45888 1792 2.0e-198 Actin-related protein 2 OS=Drosophila melanogaster GN=Arp2 PE=2 SV=3 PF10186 Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508 positive regulation of autophagy -- -- -- -- KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.38376 BF_2 16.04 0.36 2146 478259245 ENN79147.1 206 1.8e-13 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38377 BF_2 5.00 2.50 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38379 BF_2 2543.64 19.16 5840 91091506 XP_969096.1 3532 0.0e+00 PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|642936851|ref|XP_008197901.1| PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|270000934|gb|EEZ97381.1| hypothetical protein TcasGA2_TC011206 [Tribolium castaneum] 170030268 XM_001842960.1 189 2.29235e-91 Culex quinquefasciatus ubiquitin-protein ligase E3A, mRNA K10587 UBE3A, E6AP ubiquitin-protein ligase E3 A http://www.genome.jp/dbget-bin/www_bget?ko:K10587 Q05086 2156 1.6e-240 Ubiquitin-protein ligase E3A OS=Homo sapiens GN=UBE3A PE=1 SV=4 PF15798//PF00895//PF00632 Proline-rich AKT1 substrate 1//ATP synthase protein 8//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0048011//GO:0015992//GO:0032007//GO:0015986 protein ubiquitination//neurotrophin TRK receptor signaling pathway//proton transport//negative regulation of TOR signaling//ATP synthesis coupled proton transport GO:0004842//GO:0015078 ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity GO:0000276//GO:0005622 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.38380 BF_2 456.91 4.22 4819 478252421 ENN72845.1 503 1.5e-47 hypothetical protein YQE_10525, partial [Dendroctonus ponderosae]>gi|546677840|gb|ERL88597.1| hypothetical protein D910_05982 [Dendroctonus ponderosae] 642919574 XM_970177.2 87 9.50039e-35 PREDICTED: Tribolium castaneum calcineurin subunit B type 2 (LOC664163), mRNA K06268 PPP3R, CNB serine/threonine-protein phosphatase 2B regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06268 P48451 487 4.4e-47 Calcineurin subunit B type 1 OS=Drosophila melanogaster GN=CanB PE=2 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202//PF12763 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.38381 BF_2 210.71 1.98 4746 642925990 XP_008194721.1 3125 0.0e+00 PREDICTED: DNA repair and recombination protein RAD54-like [Tribolium castaneum] -- -- -- -- -- K10875 RAD54L, RAD54 DNA repair and recombination protein RAD54 and RAD54-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K10875 Q92698 2244 7.9e-251 DNA repair and recombination protein RAD54-like OS=Homo sapiens GN=RAD54L PE=1 SV=2 PF08658//PF04851//PF01484//PF00176 Rad54 N terminal//Type III restriction enzyme, res subunit//Nematode cuticle collagen N-terminal domain//SNF2 family N-terminal domain -- -- GO:0016817//GO:0042302//GO:0005524//GO:0016787//GO:0003677 hydrolase activity, acting on acid anhydrides//structural constituent of cuticle//ATP binding//hydrolase activity//DNA binding -- -- KOG0390 DNA repair protein, SNF2 family Cluster-8309.38382 BF_2 1384.50 14.63 4245 91084825 XP_973466.1 1748 5.6e-192 PREDICTED: GAS2-like protein 2 [Tribolium castaneum]>gi|642925938|ref|XP_008194703.1| PREDICTED: GAS2-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZP9 712 3.1e-73 GAS2-like protein 1 OS=Mus musculus GN=Gas2l1 PE=2 SV=1 PF00307//PF02187 Calponin homology (CH) domain//Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest GO:0005515 protein binding -- -- KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.38383 BF_2 88.34 0.52 7420 332375504 AEE62893.1 1124 2.2e-119 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 8.8e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF01166//PF02183//PF00997//PF07850//PF15898//PF04111//PF16944//PF12474 TSC-22/dip/bun family//Homeobox associated leucine zipper//Kappa casein//Renin receptor-like protein//cGMP-dependent protein kinase interacting domain//Autophagy protein Apg6//Fungal potassium channel//Polo kinase kinase GO:0006813//GO:0071805//GO:0016310//GO:0006355//GO:0007165//GO:0009069//GO:0006914 potassium ion transport//potassium ion transmembrane transport//phosphorylation//regulation of transcription, DNA-templated//signal transduction//serine family amino acid metabolic process//autophagy GO:0004872//GO:0043565//GO:0019901//GO:0003700//GO:0004674//GO:0015079 receptor activity//sequence-specific DNA binding//protein kinase binding//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity//potassium ion transmembrane transporter activity GO:0005576//GO:0005667//GO:0016021//GO:0005887 extracellular region//transcription factor complex//integral component of membrane//integral component of plasma membrane KOG4001 Axonemal dynein light chain Cluster-8309.38384 BF_2 956.88 25.65 1848 189237914 XP_969710.2 1350 3.5e-146 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q06190 154 6.9e-09 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens GN=PPP2R3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38387 BF_2 596.55 2.53 10134 156564242 NP_001096047.1 2302 7.7e-256 chitin deacetylase 2 isoform A precursor [Tribolium castaneum]>gi|155675832|gb|ABU25224.1| chitin deacetylase 2A [Tribolium castaneum] 332374221 BT127290.1 543 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA -- -- -- -- O16011 733 2.7e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF01522//PF01607//PF00642//PF00057 MMPL family//Polysaccharide deacetylase//Chitin binding Peritrophin-A domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Low-density lipoprotein receptor domain class A GO:0006030//GO:0006040//GO:0005975//GO:0006807 chitin metabolic process//amino sugar metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0005515//GO:0046872//GO:0004099//GO:0016810//GO:0008061 protein binding//metal ion binding//chitin deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0016020//GO:0005576 membrane//extracellular region KOG2494 C3H1-type Zn-finger protein Cluster-8309.38388 BF_2 796.19 9.82 3678 332376995 AEE63637.1 1603 3.2e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 208 3.94323e-102 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 3.0e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00887//PF00487 Acyl CoA binding protein//Fatty acid desaturase GO:0006629 lipid metabolic process GO:0000062 fatty-acyl-CoA binding -- -- KOG2987 Fatty acid desaturase Cluster-8309.38389 BF_2 191.00 3.49 2576 189238706 XP_001811763.1 1575 3.9e-172 PREDICTED: calcium-independent phospholipase A2-gamma-like [Tribolium castaneum] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q5XTS1 984 5.5e-105 Calcium-independent phospholipase A2-gamma OS=Oryctolagus cuniculus GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.38390 BF_2 2578.70 37.81 3140 642915765 XP_008200071.1 1069 2.2e-113 PREDICTED: zinc finger protein ubi-d4 B-like [Tribolium castaneum] 641653063 XM_003241514.2 58 8.14656e-19 PREDICTED: Acyrthosiphon pisum zinc finger protein ubi-d4 (LOC100161288), transcript variant X3, mRNA K13196 DPF2, REQ zinc finger protein ubi-d4 http://www.genome.jp/dbget-bin/www_bget?ko:K13196 Q9W638 366 3.0e-33 Zinc finger protein ubi-d4 A OS=Xenopus laevis GN=req-a PE=2 SV=1 PF00096//PF00628//PF02064//PF16866 Zinc finger, C2H2 type//PHD-finger//MAS20 protein import receptor//PHD-finger GO:0006886//GO:0006605 intracellular protein transport//protein targeting GO:0005515//GO:0046872 protein binding//metal ion binding GO:0005742 mitochondrial outer membrane translocase complex KOG1244 Predicted transcription factor Requiem/NEURO-D4 Cluster-8309.38392 BF_2 675.05 6.88 4390 642918838 XP_008191608.1 2788 0.0e+00 PREDICTED: breast carcinoma-amplified sequence 3 homolog isoform X1 [Tribolium castaneum] 642918837 XM_008193386.1 258 7.56055e-130 PREDICTED: Tribolium castaneum breast carcinoma-amplified sequence 3 homolog (LOC661755), transcript variant X1, mRNA -- -- -- -- Q8SY41 1526 1.3e-167 Breast carcinoma-amplified sequence 3 homolog OS=Drosophila melanogaster GN=rudhira PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2109 WD40 repeat protein Cluster-8309.38395 BF_2 3711.71 40.83 4090 189241616 XP_966968.2 953 8.3e-100 PREDICTED: cyclic AMP response element-binding protein A-like isoform X3 [Tribolium castaneum] 195590478 XM_002084937.1 97 2.22308e-40 Drosophila simulans GD14552 (Dsim\GD14552), mRNA K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 P29747 388 1.1e-35 Cyclic AMP response element-binding protein A OS=Drosophila melanogaster GN=CrebA PE=1 SV=2 PF04111//PF01544//PF00170//PF06005//PF03131//PF07926//PF02183//PF07716 Autophagy protein Apg6//CorA-like Mg2+ transporter protein//bZIP transcription factor//Protein of unknown function (DUF904)//bZIP Maf transcription factor//TPR/MLP1/MLP2-like protein//Homeobox associated leucine zipper//Basic region leucine zipper GO:0000917//GO:0043093//GO:0006606//GO:0006355//GO:0006914//GO:0030001//GO:0055085 barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//metal ion transport//transmembrane transport GO:0003700//GO:0043565//GO:0046873//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//metal ion transmembrane transporter activity//DNA binding GO:0005737//GO:0016020//GO:0005667//GO:0005634 cytoplasm//membrane//transcription factor complex//nucleus KOG0709 CREB/ATF family transcription factor Cluster-8309.38396 BF_2 3814.80 74.72 2423 642921511 XP_008192900.1 2876 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECTD1 [Tribolium castaneum] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q9ULT8 1759 7.0e-195 E3 ubiquitin-protein ligase HECTD1 OS=Homo sapiens GN=HECTD1 PE=1 SV=3 PF02747//PF00632 Proliferating cell nuclear antigen, C-terminal domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006275 protein ubiquitination//regulation of DNA replication GO:0004842//GO:0003677 ubiquitin-protein transferase activity//DNA binding -- -- KOG0170 E3 ubiquitin protein ligase Cluster-8309.38397 BF_2 9.48 1.81 506 669214630 CDW61305.1 215 3.8e-15 hypothetical protein TTRE_0000975601 [Trichuris trichiura] 296881992 HM046535.1 393 0 Prionus asiaticus voucher CNE1001 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM6 187 2.8e-13 Protein TAR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TAR1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38399 BF_2 2894.97 38.25 3453 189235332 XP_001816025.1 646 2.8e-64 PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tribolium castaneum]>gi|270003646|gb|EFA00094.1| hypothetical protein TcasGA2_TC002909 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF00822//PF13903//PF10204//PF04226 Ligand-gated ion channel//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction//Dual oxidase maturation factor//Transglycosylase associated protein GO:0015031//GO:0006811//GO:0007268//GO:0007165 protein transport//ion transport//synaptic transmission//signal transduction GO:0004970 ionotropic glutamate receptor activity GO:0016020//GO:0016021//GO:0005789 membrane//integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.384 BF_2 27.00 0.81 1677 759073837 XP_011346583.1 227 5.2e-16 PREDICTED: LOW QUALITY PROTEIN: trihelix transcription factor GT-1-like [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3840 BF_2 3.00 0.40 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38400 BF_2 51.19 0.66 3548 189235332 XP_001816025.1 646 2.8e-64 PREDICTED: voltage-dependent calcium channel gamma-7 subunit [Tribolium castaneum]>gi|270003646|gb|EFA00094.1| hypothetical protein TcasGA2_TC002909 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903//PF04226//PF10204//PF00822//PF00060 PMP-22/EMP/MP20/Claudin tight junction//Transglycosylase associated protein//Dual oxidase maturation factor//PMP-22/EMP/MP20/Claudin family//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0015031//GO:0006811 signal transduction//synaptic transmission//protein transport//ion transport GO:0004970 ionotropic glutamate receptor activity GO:0005789//GO:0016021//GO:0016020 endoplasmic reticulum membrane//integral component of membrane//membrane -- -- Cluster-8309.38401 BF_2 134.80 1.75 3508 91076824 XP_967870.1 1208 1.9e-129 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 729 2.8e-75 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- KOG1212 Amidases Cluster-8309.38402 BF_2 662.59 11.46 2706 642927984 XP_008195472.1 731 3.0e-74 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38403 BF_2 248.09 6.19 1965 642927984 XP_008195472.1 728 4.9e-74 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38406 BF_2 703.23 3.50 8700 478258659 ENN78709.1 2012 2.8e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.98211e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 770 1.2e-79 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07500//PF00628//PF07533//PF06427 Transcription factor S-II (TFIIS), central domain//PHD-finger//BRK domain//UDP-glucose:Glycoprotein Glucosyltransferase GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0016817//GO:0003980//GO:0005515 hydrolase activity, acting on acid anhydrides//UDP-glucose:glycoprotein glucosyltransferase activity//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.38408 BF_2 61.68 0.81 3454 646713353 KDR17743.1 232 2.8e-16 Brevican core protein, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P22897 190 8.6e-13 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF02028 BCCT, betaine/carnitine/choline family transporter GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.38410 BF_2 19.35 1.96 700 478252681 ENN73077.1 363 3.7e-32 hypothetical protein YQE_10281, partial [Dendroctonus ponderosae]>gi|546682841|gb|ERL92730.1| hypothetical protein D910_10040 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38412 BF_2 231.65 4.10 2653 642931533 XP_008196625.1 1374 8.2e-149 PREDICTED: WW domain-containing oxidoreductase [Tribolium castaneum] -- -- -- -- -- K19329 WWOX WW domain-containing oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K19329 Q9VLU5 985 4.3e-105 WW domain-containing oxidoreductase OS=Drosophila melanogaster GN=Wwox PE=2 SV=1 PF00397//PF00106 WW domain//short chain dehydrogenase GO:0008152 metabolic process GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.38414 BF_2 3.00 49.48 221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38415 BF_2 103.53 0.51 8728 642930342 XP_008196356.1 5278 0.0e+00 PREDICTED: trichohyalin [Tribolium castaneum] 642930341 XM_008198134.1 1112 0 PREDICTED: Tribolium castaneum trichohyalin (LOC661978), mRNA -- -- -- -- P35580 408 1.1e-37 Myosin-10 OS=Homo sapiens GN=MYH10 PE=1 SV=3 PF06156//PF05550//PF16331//PF00901//PF10174//PF07195//PF10473//PF07989//PF03836//PF02183//PF08657//PF00769 Protein of unknown function (DUF972)//Pestivirus Npro endopeptidase C53//TolA binding protein trimerisation//Orbivirus outer capsid protein VP5//RIM-binding protein of the cytomatrix active zone//Flagellar hook-associated protein 2 C-terminus//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//RasGAP C-terminus//Homeobox associated leucine zipper//DASH complex subunit Spc34//Ezrin/radixin/moesin family GO:0006260//GO:0008608//GO:0019082//GO:0006355//GO:0070206//GO:0007264//GO:0007155//GO:0016032 DNA replication//attachment of spindle microtubules to kinetochore//viral protein processing//regulation of transcription, DNA-templated//protein trimerization//small GTPase mediated signal transduction//cell adhesion//viral process GO:0003700//GO:0043565//GO:0008134//GO:0045502//GO:0005198//GO:0005096//GO:0042803//GO:0008092 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//transcription factor binding//dynein binding//structural molecule activity//GTPase activator activity//protein homodimerization activity//cytoskeletal protein binding GO:0005876//GO:0005737//GO:0009288//GO:0048786//GO:0042729//GO:0019028//GO:0005815//GO:0019898//GO:0005667//GO:0030286 spindle microtubule//cytoplasm//bacterial-type flagellum//presynaptic active zone//DASH complex//viral capsid//microtubule organizing center//extrinsic component of membrane//transcription factor complex//dynein complex -- -- Cluster-8309.38416 BF_2 62.28 0.56 4903 270004788 EFA01236.1 453 9.4e-42 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38417 BF_2 329.63 6.06 2564 478251025 ENN71506.1 1152 4.4e-123 hypothetical protein YQE_11799, partial [Dendroctonus ponderosae]>gi|546679474|gb|ERL89938.1| hypothetical protein D910_07297 [Dendroctonus ponderosae] -- -- -- -- -- K10052 CEBPN CCAAT/enhancer binding protein (C/EBP), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K10052 Q02637 261 3.7e-21 CCAAT/enhancer-binding protein OS=Drosophila melanogaster GN=slbo PE=1 SV=3 PF11023//PF07716//PF00170 Zinc-ribbon containing domain//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005887 transcription factor complex//integral component of plasma membrane -- -- Cluster-8309.38420 BF_2 1025.25 11.38 4055 189240845 XP_001812763.1 3538 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 393809286 JQ824200.1 481 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 2321 7.9e-260 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF01637//PF08314//PF02883//PF02985//PF04670//PF00071//PF00503//PF08367//PF01926//PF13304//PF08477//PF00025//PF01602 Archaeal ATPase//Secretory pathway protein Sec39//Adaptin C-terminal domain//HEAT repeat//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//Peptidase M16C associated//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Adaptin N terminal region GO:0006508//GO:0006890//GO:0007264//GO:0007186//GO:0007165//GO:0016192//GO:0006886 proteolysis//retrograde vesicle-mediated transport, Golgi to ER//small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction//vesicle-mediated transport//intracellular protein transport GO:0004871//GO:0005525//GO:0005515//GO:0019001//GO:0031683//GO:0005524//GO:0003924 signal transducer activity//GTP binding//protein binding//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.38422 BF_2 929.70 11.13 3782 642910503 XP_008200242.1 2679 5.5e-300 PREDICTED: phospholipase DDHD2 isoform X1 [Tribolium castaneum] 826487484 XM_012683938.1 80 5.79279e-31 PREDICTED: Monomorium pharaonis SEC23-interacting protein-like (LOC105838396), transcript variant X4, mRNA -- -- -- -- Q9Y6Y8 1018 9.1e-109 SEC23-interacting protein OS=Homo sapiens GN=SEC23IP PE=1 SV=1 PF02862//PF13724 DDHD domain//DNA-binding domain -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.38423 BF_2 25.53 0.47 2575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00724 NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.38424 BF_2 147.21 0.88 7306 189241670 XP_001807691.1 252 2.9e-18 PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum]>gi|642937361|ref|XP_008198805.1| PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 Q9M8S8 232 2.4e-17 Inositol-phosphate phosphatase OS=Arabidopsis thaliana GN=VTC4 PE=1 SV=1 PF05739//PF04159//PF02935//PF03664 SNARE domain//NB glycoprotein//Cytochrome c oxidase subunit VIIc//Glycosyl hydrolase family 62 GO:0006123//GO:0046373//GO:0009117//GO:0015992//GO:0005975 mitochondrial electron transport, cytochrome c to oxygen//L-arabinose metabolic process//nucleotide metabolic process//proton transport//carbohydrate metabolic process GO:0046556//GO:0005515//GO:0004129 alpha-L-arabinofuranosidase activity//protein binding//cytochrome-c oxidase activity GO:0016021//GO:0045277 integral component of membrane//respiratory chain complex IV KOG2951 Inositol monophosphatase Cluster-8309.38425 BF_2 9336.00 864.34 739 -- -- -- -- -- 170045304 XM_001850203.1 40 1.87784e-09 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF08099 Scorpion calcine family GO:0009405//GO:0006810 pathogenesis//transport GO:0019855 calcium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.38426 BF_2 1103.32 4.82 9860 91085247 XP_973234.1 3413 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 316 9.76676e-162 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2247 7.4e-251 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF06009//PF14372//PF07690//PF00083//PF02985//PF00015//PF08064//PF11698//PF05997 Laminin Domain II//Domain of unknown function (DUF4413)//Major Facilitator Superfamily//Sugar (and other) transporter//HEAT repeat//Methyl-accepting chemotaxis protein (MCP) signalling domain//UME (NUC010) domain//V-ATPase subunit H//Nucleolar protein,Nop52 GO:0007155//GO:0016310//GO:0015991//GO:0006364//GO:0009069//GO:0055085//GO:0007165 cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport//rRNA processing//serine family amino acid metabolic process//transmembrane transport//signal transduction GO:0004871//GO:0005515//GO:0016820//GO:0022857//GO:0003677//GO:0004674 signal transducer activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//transmembrane transporter activity//DNA binding//protein serine/threonine kinase activity GO:0016020//GO:0000221//GO:0016021//GO:0030688 membrane//vacuolar proton-transporting V-type ATPase, V1 domain//integral component of membrane//preribosome, small subunit precursor KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.38427 BF_2 515.59 5.42 4265 546683122 ERL92973.1 1762 1.3e-193 hypothetical protein D910_10276 [Dendroctonus ponderosae] 237874246 NM_001160401.1 165 3.66706e-78 Acyrthosiphon pisum aspartyl-tRNA synthetase (Aats-asp), mRNA K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 P14868 1470 4.0e-161 Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens GN=DARS PE=1 SV=2 PF02817//PF11538//PF01409//PF02064//PF00152//PF01336 e3 binding domain//Snurportin1//tRNA synthetases class II core domain (F)//MAS20 protein import receptor//tRNA synthetases class II (D, K and N)//OB-fold nucleic acid binding domain GO:0006418//GO:0043039//GO:0006605//GO:0008152//GO:0006886 tRNA aminoacylation for protein translation//tRNA aminoacylation//protein targeting//metabolic process//intracellular protein transport GO:0000166//GO:0003676//GO:0004812//GO:0005524//GO:0016746//GO:0005515//GO:0000049 nucleotide binding//nucleic acid binding//aminoacyl-tRNA ligase activity//ATP binding//transferase activity, transferring acyl groups//protein binding//tRNA binding GO:0005737//GO:0005742 cytoplasm//mitochondrial outer membrane translocase complex KOG0556 Aspartyl-tRNA synthetase Cluster-8309.38428 BF_2 2100.00 14.47 6357 642925387 XP_008194528.1 3541 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q5XF89 2102 3.1e-234 Probable cation-transporting ATPase 13A3 OS=Mus musculus GN=Atp13a3 PE=1 SV=1 PF12409//PF00122//PF00083//PF07690 P5-type ATPase cation transporter//E1-E2 ATPase//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0046872//GO:0000166//GO:0016887//GO:0022857 metal ion binding//nucleotide binding//ATPase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.38429 BF_2 705.56 33.89 1158 283046718 NP_001164305.1 1095 8.0e-117 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 252 4.22752e-127 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q0MQI5 987 1.1e-105 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Gorilla gorilla gorilla GN=NDUFV1 PE=2 SV=1 -- -- GO:0006744//GO:0006814//GO:0055114//GO:0015992//GO:0006120 ubiquinone biosynthetic process//sodium ion transport//oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0051539//GO:0010181//GO:0051287 NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding//FMN binding//NAD binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.38430 BF_2 19.10 0.35 2569 546675642 ERL86792.1 495 6.7e-47 hypothetical protein D910_04198 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TPQ9 145 1.1e-07 Arrestin domain-containing protein 3 OS=Mus musculus GN=Arrdc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.38431 BF_2 50.29 0.33 6636 642918534 XP_008191512.1 5606 0.0e+00 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I7U4 2813 0.0e+00 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF16794//PF14604//PF00018//PF13895//PF00041//PF16656 Fibronectin-III type domain//Variant SH3 domain//SH3 domain//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.38432 BF_2 2590.00 12.66 8844 642918912 XP_008191652.1 4654 0.0e+00 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase classes I and II [Tribolium castaneum] 198473796 XM_001356410.2 231 1.56161e-114 Drosophila pseudoobscura pseudoobscura GA18269 (Dpse\GA18269), partial mRNA K05858 PLCB phosphatidylinositol phospholipase C, beta http://www.genome.jp/dbget-bin/www_bget?ko:K05858 Q9NQ66 2123 1.6e-236 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 OS=Homo sapiens GN=PLCB1 PE=1 SV=1 PF00387//PF01130//PF08703 Phosphatidylinositol-specific phospholipase C, Y domain//CD36 family//PLC-beta C terminal GO:0007155//GO:0016042//GO:0035556//GO:0007165//GO:0046339//GO:0009395//GO:0006629 cell adhesion//lipid catabolic process//intracellular signal transduction//signal transduction//diacylglycerol metabolic process//phospholipid catabolic process//lipid metabolic process GO:0005509//GO:0004435 calcium ion binding//phosphatidylinositol phospholipase C activity GO:0016020 membrane KOG1265 Phospholipase C Cluster-8309.38434 BF_2 125.21 0.56 9703 570341960 AHE77377.1 2394 1.6e-266 heat shock protein 70 [Lissorhoptrus oryzophilus] 283827878 GU289400.1 806 0 Mantichorula semenowi heat shock protein 70 (HSP70) mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 Q9U639 2321 1.9e-259 Heat shock 70 kDa protein cognate 4 OS=Manduca sexta PE=2 SV=1 PF02782//PF08303//PF01073//PF00106//PF05739//PF01223//PF04625//PF06723//PF00033//PF01194//PF02491//PF01370//PF01968 FGGY family of carbohydrate kinases, C-terminal domain//tRNA ligase kinase domain//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//SNARE domain//DNA/RNA non-specific endonuclease//DEC-1 protein, N-terminal region//MreB/Mbl protein//Cytochrome b/b6/petB//RNA polymerases N / 8 kDa subunit//SHS2 domain inserted in FTSA//NAD dependent epimerase/dehydratase family//Hydantoinase/oxoprolinase GO:0008207//GO:0000902//GO:0055114//GO:0005975//GO:0006388//GO:0022904//GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0007304//GO:0007049//GO:0006351//GO:0006144//GO:0006206 C21-steroid hormone metabolic process//cell morphogenesis//oxidation-reduction process//carbohydrate metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//respiratory electron transport chain//metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//chorion-containing eggshell formation//cell cycle//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0005524//GO:0003854//GO:0016616//GO:0016491//GO:0016773//GO:0003676//GO:0046872//GO:0050662//GO:0005213//GO:0003899//GO:0016787//GO:0003972//GO:0003824//GO:0003677//GO:0005515 ATP binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//phosphotransferase activity, alcohol group as acceptor//nucleic acid binding//metal ion binding//coenzyme binding//structural constituent of chorion//DNA-directed RNA polymerase activity//hydrolase activity//RNA ligase (ATP) activity//catalytic activity//DNA binding//protein binding GO:0005730//GO:0042600//GO:0005576//GO:0016020 nucleolus//chorion//extracellular region//membrane KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.38435 BF_2 2274.36 18.78 5353 91083881 XP_967558.1 1326 6.1e-143 PREDICTED: D-3-phosphoglycerate dehydrogenase [Tribolium castaneum]>gi|270006715|gb|EFA03163.1| hypothetical protein TcasGA2_TC013082 [Tribolium castaneum] -- -- -- -- -- K00058 serA, PHGDH D-3-phosphoglycerate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00058 Q61753 887 2.0e-93 D-3-phosphoglycerate dehydrogenase OS=Mus musculus GN=Phgdh PE=1 SV=3 PF02826//PF03446//PF00389//PF07347 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//NADH:ubiquinone oxidoreductase subunit B14.5a (Complex I-B14.5a) GO:0006098//GO:0008152//GO:0006744//GO:0006544//GO:0006564//GO:0042773//GO:0006120//GO:0006814//GO:0006566//GO:0019521//GO:0015992//GO:0055114 pentose-phosphate shunt//metabolic process//ubiquinone biosynthetic process//glycine metabolic process//L-serine biosynthetic process//ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone//sodium ion transport//threonine metabolic process//D-gluconate metabolic process//proton transport//oxidation-reduction process GO:0051287//GO:0004617//GO:0016616//GO:0004616//GO:0008137 NAD binding//phosphoglycerate dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane KOG0068 D-3-phosphoglycerate dehydrogenase, D-isomer-specific 2-hydroxy acid dehydrogenase superfamily Cluster-8309.38437 BF_2 461.42 1.99 9984 642914147 XP_008201565.1 9361 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1238 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.1e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.38438 BF_2 383.90 4.78 3650 571529397 XP_006567771.1 1762 1.1e-193 PREDICTED: nucleolar protein 58-like [Apis mellifera] 242020751 XM_002430770.1 269 4.81711e-136 Pediculus humanus corporis Nucleolar protein NOP5, putative, mRNA K14565 NOP58 nucleolar protein 58 http://www.genome.jp/dbget-bin/www_bget?ko:K14565 Q9QZ86 1418 3.7e-155 Nucleolar protein 58 OS=Rattus norvegicus GN=Nop58 PE=1 SV=1 PF04858 TH1 protein GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2572 Ribosome biogenesis protein - Nop58p/Nop5p Cluster-8309.38441 BF_2 43.10 1.23 1757 642920190 XP_008192241.1 460 5.2e-43 PREDICTED: protein lin-52 homolog [Tribolium castaneum]>gi|270005293|gb|EFA01741.1| hypothetical protein TcasGA2_TC007337 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0AUQ6 254 1.7e-20 Protein lin-52 homolog OS=Danio rerio GN=lin52 PE=3 SV=1 PF03791//PF10044 KNOX2 domain//Retinal tissue protein GO:0007049//GO:0006351 cell cycle//transcription, DNA-templated GO:0003677 DNA binding GO:0070176//GO:0005634 DRM complex//nucleus -- -- Cluster-8309.38443 BF_2 102.56 1.11 4143 642918982 XP_008191684.1 4667 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.28995e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3159 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0206 P-type ATPase Cluster-8309.38445 BF_2 9485.87 220.72 2085 91087441 XP_975685.1 230 2.9e-16 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27017 169 1.4e-10 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.38446 BF_2 210.58 1.47 6293 642926040 XP_008194740.1 8557 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 1035 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 6122 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF07478//PF02786//PF02655//PF08326 D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//ATP-grasp domain//Acetyl-CoA carboxylase, central region GO:0046436//GO:0006633//GO:0009252//GO:0006090 D-alanine metabolic process//fatty acid biosynthetic process//peptidoglycan biosynthetic process//pyruvate metabolic process GO:0005524//GO:0046872//GO:0008716//GO:0003989 ATP binding//metal ion binding//D-alanine-D-alanine ligase activity//acetyl-CoA carboxylase activity GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.38447 BF_2 127.43 2.04 2900 385845164 AFI81409.1 1440 2.0e-156 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 56 9.72342e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 586 8.7e-59 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF03099//PF03728//PF08127 Biotin/lipoate A/B protein ligase family//Viral DNA-binding protein, zinc binding domain//Peptidase family C1 propeptide GO:0050790//GO:0006508//GO:0006260//GO:0006464 regulation of catalytic activity//proteolysis//DNA replication//cellular protein modification process GO:0004197//GO:0003677//GO:0008270 cysteine-type endopeptidase activity//DNA binding//zinc ion binding -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.38449 BF_2 251.72 3.02 3779 270010219 EFA06667.1 2551 3.8e-285 hypothetical protein TcasGA2_TC009594 [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 951 5.4e-101 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF07646//PF00651//PF01344 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.38453 BF_2 1306.34 10.85 5325 642927920 XP_008195448.1 2122 3.0e-235 PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927922|ref|XP_008195449.1| PREDICTED: dystroglycan [Tribolium castaneum]>gi|642927924|ref|XP_974516.2| PREDICTED: dystroglycan [Tribolium castaneum] 642927923 XM_969423.3 68 3.83227e-24 PREDICTED: Tribolium castaneum dystroglycan (LOC663372), transcript variant X3, mRNA K06265 DAG1 dystroglycan 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06265 Q9TSZ6 506 3.0e-49 Dystroglycan OS=Canis familiaris GN=DAG1 PE=3 SV=1 PF05454//PF03176 Dystroglycan (Dystrophin-associated glycoprotein 1)//MMPL family GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016020//GO:0016010 membrane//dystrophin-associated glycoprotein complex KOG3781 Dystroglycan Cluster-8309.38455 BF_2 1354.79 14.09 4310 642919644 XP_008192004.1 1576 5.0e-172 PREDICTED: fatty acid hydroxylase domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 Q9GKT2 894 2.5e-94 Fatty acid hydroxylase domain-containing protein 2 OS=Macaca fascicularis GN=FAXDC2 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity -- -- KOG0873 C-4 sterol methyl oxidase Cluster-8309.38456 BF_2 1528.59 43.06 1772 332376226 AEE63253.1 1767 1.5e-194 unknown [Dendroctonus ponderosae] 282158080 NM_001170613.1 385 0 Tribolium castaneum arrestin 2 (Arr2), mRNA K13805 ARR2 arrestin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13805 P32122 1583 1.3e-174 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.38458 BF_2 324.82 3.51 4160 642920920 XP_008192616.1 930 3.9e-97 PREDICTED: uncharacterized protein LOC103312812 [Tribolium castaneum]>gi|270005158|gb|EFA01606.1| hypothetical protein TcasGA2_TC007172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434//PF00520//PF10798//PF02706//PF15957 TMEM9//Ion transport protein//Biofilm development protein YmgB/AriR//Chain length determinant protein//Commissureless GO:0006811//GO:0042710//GO:0071229//GO:0055085//GO:0009103//GO:0007411 ion transport//biofilm formation//cellular response to acid chemical//transmembrane transport//lipopolysaccharide biosynthetic process//axon guidance GO:0005216 ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.38460 BF_2 9430.58 48.38 8441 270001798 EEZ98245.1 3839 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 470 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q14554 162 3.7e-09 Protein disulfide-isomerase A5 OS=Homo sapiens GN=PDIA5 PE=1 SV=1 PF08534//PF02382//PF00578//PF02020//PF02724//PF00085//PF07689//PF06524//PF01791 Redoxin//RTX N-terminal domain//AhpC/TSA family//eIF4-gamma/eIF5/eIF2-epsilon//CDC45-like protein//Thioredoxin//KaiB domain//NOA36 protein//DeoC/LacD family aldolase GO:0009405//GO:0048511//GO:0006270//GO:0055114//GO:0045454 pathogenesis//rhythmic process//DNA replication initiation//oxidation-reduction process//cell redox homeostasis GO:0005515//GO:0016491//GO:0005509//GO:0008270//GO:0016209//GO:0016829 protein binding//oxidoreductase activity//calcium ion binding//zinc ion binding//antioxidant activity//lyase activity GO:0005634//GO:0005576 nucleus//extracellular region KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.38462 BF_2 163.78 1.26 5707 642914502 XP_008201702.1 1282 8.2e-138 PREDICTED: RUN and FYVE domain-containing protein 2 isoform X2 [Tribolium castaneum] 831282704 XM_012817043.1 41 4.1972e-09 PREDICTED: Clupea harengus RUN and FYVE domain containing 2 (rufy2), mRNA -- -- -- -- Q5R5R4 715 1.9e-73 RUN and FYVE domain-containing protein 2 OS=Pongo abelii GN=RUFY2 PE=2 SV=1 PF05191//PF02841//PF07926//PF01363//PF10473//PF00038//PF08657//PF08702//PF14634//PF06005//PF01155//PF03462//PF08172 Adenylate kinase, active site lid//Guanylate-binding protein, C-terminal domain//TPR/MLP1/MLP2-like protein//FYVE zinc finger//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Intermediate filament protein//DASH complex subunit Spc34//Fibrinogen alpha/beta chain family//zinc-RING finger domain//Protein of unknown function (DUF904)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//PCRF domain//CASP C terminal GO:0006891//GO:0030168//GO:0006415//GO:0008608//GO:0006606//GO:0006449//GO:0006144//GO:0043093//GO:0000917//GO:0007165//GO:0006464//GO:0046034//GO:0051258 intra-Golgi vesicle-mediated transport//platelet activation//translational termination//attachment of spindle microtubules to kinetochore//protein import into nucleus//regulation of translational termination//purine nucleobase metabolic process//FtsZ-dependent cytokinesis//barrier septum assembly//signal transduction//cellular protein modification process//ATP metabolic process//protein polymerization GO:0030674//GO:0046872//GO:0045502//GO:0003924//GO:0008134//GO:0005102//GO:0005515//GO:0016149//GO:0016151//GO:0005525//GO:0042803//GO:0005198//GO:0008270//GO:0004017 protein binding, bridging//metal ion binding//dynein binding//GTPase activity//transcription factor binding//receptor binding//protein binding//translation release factor activity, codon specific//nickel cation binding//GTP binding//protein homodimerization activity//structural molecule activity//zinc ion binding//adenylate kinase activity GO:0030286//GO:0005667//GO:0030173//GO:0005882//GO:0005577//GO:0018444//GO:0042729//GO:0005840//GO:0005737//GO:0005876 dynein complex//transcription factor complex//integral component of Golgi membrane//intermediate filament//fibrinogen complex//translation release factor complex//DASH complex//ribosome//cytoplasm//spindle microtubule -- -- Cluster-8309.38465 BF_2 27.97 0.98 1485 282158091 NP_001164089.1 488 2.5e-46 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P05369 292 5.5e-25 Farnesyl pyrophosphate synthase OS=Rattus norvegicus GN=Fdps PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.38468 BF_2 43.42 0.64 3116 270007722 EFA04170.1 2227 1.2e-247 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 775 1.1e-80 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.38469 BF_2 281.61 2.26 5497 642930795 XP_008196094.1 4759 0.0e+00 PREDICTED: tight junction protein ZO-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 Q9UDY2 891 7.1e-94 Tight junction protein ZO-2 OS=Homo sapiens GN=TJP2 PE=1 SV=2 PF00018//PF00595//PF13180 SH3 domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3580 Tight junction proteins Cluster-8309.3847 BF_2 18.00 0.55 1659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38470 BF_2 117.13 1.39 3800 91086631 XP_966390.1 1013 8.5e-107 PREDICTED: abhydrolase domain-containing protein 2 [Tribolium castaneum]>gi|270010379|gb|EFA06827.1| hypothetical protein TcasGA2_TC009769 [Tribolium castaneum] -- -- -- -- -- K13697 ABHD2 abhydrolase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13697 Q24093 870 1.3e-91 Abhydrolase domain-containing protein 2 OS=Drosophila melanogaster GN=Hydr2 PE=2 SV=2 PF01083//PF01738//PF02230//PF00326//PF01764 Cutinase//Dienelactone hydrolase family//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3) GO:0006629//GO:0006508//GO:0008152 lipid metabolic process//proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG1838 Alpha/beta hydrolase Cluster-8309.38471 BF_2 16.52 0.36 2213 91083699 XP_969478.1 1065 4.6e-113 PREDICTED: periostin [Tribolium castaneum]>gi|270007879|gb|EFA04327.1| hypothetical protein TcasGA2_TC014621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38472 BF_2 740.83 10.84 3146 642916369 XP_008190992.1 1606 1.2e-175 PREDICTED: TOM1-like protein 2 isoform X1 [Tribolium castaneum]>gi|270004201|gb|EFA00649.1| hypothetical protein TcasGA2_TC003525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRX1 845 8.7e-89 TOM1-like protein 2 OS=Mus musculus GN=Tom1l2 PE=2 SV=1 PF03127//PF00790 GAT domain//VHS domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular KOG1087 Cytosolic sorting protein GGA2/TOM1 Cluster-8309.38474 BF_2 919.00 51.13 1039 91083699 XP_969478.1 949 6.1e-100 PREDICTED: periostin [Tribolium castaneum]>gi|270007879|gb|EFA04327.1| hypothetical protein TcasGA2_TC014621 [Tribolium castaneum] 642924333 XM_964385.3 145 1.14408e-67 PREDICTED: Tribolium castaneum periostin (LOC657966), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38476 BF_2 96.00 3.08 1592 91087181 XP_975417.1 912 1.8e-95 PREDICTED: mediator of RNA polymerase II transcription subunit 6 [Tribolium castaneum] -- -- -- -- -- K15128 MED6 mediator of RNA polymerase II transcription subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K15128 Q7Q107 740 6.6e-77 Mediator of RNA polymerase II transcription subunit 6 OS=Anopheles gambiae GN=MED6 PE=3 SV=3 PF04934 MED6 mediator sub complex component GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3169 RNA polymerase II transcriptional regulation mediator Cluster-8309.38477 BF_2 5.01 0.33 923 91093667 XP_975936.1 635 1.4e-63 PREDICTED: 60S acidic ribosomal protein P0 [Tribolium castaneum]>gi|270008063|gb|EFA04511.1| hypothetical protein TcasGA2_TC016306 [Tribolium castaneum] 39651866 AJ534439.1 161 1.29075e-76 Timarcha balearica mRNA for 60S acidic ribosomal protein P0 (rpP0 gene) K02941 RP-LP0, RPLP0 large subunit ribosomal protein LP0 http://www.genome.jp/dbget-bin/www_bget?ko:K02941 Q9U3U0 588 1.6e-59 60S acidic ribosomal protein P0 OS=Ceratitis capitata GN=RpLP0 PE=3 SV=1 PF00466//PF08106 Ribosomal protein L10//Formaecin family GO:0006414//GO:0042742//GO:0042254//GO:0042381 translational elongation//defense response to bacterium//ribosome biogenesis//hemolymph coagulation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0815 60S acidic ribosomal protein P0 Cluster-8309.38478 BF_2 2038.97 32.01 2952 270014159 EFA10607.1 563 1.0e-54 hypothetical protein TcasGA2_TC012868 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 426 3.2e-40 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00102//PF08777//PF04179//PF16367//PF00076//PF01416//PF01529//PF00782//PF02868 Protein-tyrosine phosphatase//RNA binding motif//Initiator tRNA phosphoribosyl transferase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA pseudouridine synthase//DHHC palmitoyltransferase//Dual specificity phosphatase, catalytic domain//Thermolysin metallopeptidase, alpha-helical domain GO:0006570//GO:0006470//GO:0019988//GO:0001522//GO:0009451 tyrosine metabolic process//protein dephosphorylation//charged-tRNA amino acid modification//pseudouridine synthesis//RNA modification GO:0004725//GO:0008138//GO:0043399//GO:0004222//GO:0003723//GO:0009982//GO:0003676//GO:0008270 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//metalloendopeptidase activity//RNA binding//pseudouridine synthase activity//nucleic acid binding//zinc ion binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.38480 BF_2 1476.48 15.64 4236 642916400 XP_008191007.1 1394 6.3e-151 PREDICTED: protein cueball [Tribolium castaneum] 827558792 XM_004931531.2 37 5.2016e-07 PREDICTED: Bombyx mori protein cueball (LOC101741085), mRNA K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 B3M8G0 742 1.0e-76 Protein cueball OS=Drosophila ananassae GN=cue PE=3 SV=1 PF05393//PF00008 Human adenovirus early E3A glycoprotein//EGF-like domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.38482 BF_2 1042.59 14.58 3278 546686533 ERL95731.1 499 2.9e-47 hypothetical protein D910_00173, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38485 BF_2 1437.43 11.16 5675 189234402 XP_974971.2 1311 3.5e-141 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] 356640774 JN597285.1 870 0 Anastrepha suspensa transformer female-specific transcript variant and truncated transformer male-specific transcript (tra) gene, complete cds, alternatively spliced -- -- -- -- Q5VY43 328 1.4e-28 Platelet endothelial aggregation receptor 1 OS=Homo sapiens GN=PEAR1 PE=1 SV=1 PF01414//PF04790//PF00008//PF10288//PF05699 Delta serrate ligand//Sarcoglycan complex subunit protein//EGF-like domain//Cytoplasmic tRNA 2-thiolation protein 2//hAT family C-terminal dimerisation region GO:0002098//GO:0034227//GO:0007154 tRNA wobble uridine modification//tRNA thio-modification//cell communication GO:0000049//GO:0005515//GO:0046983 tRNA binding//protein binding//protein dimerization activity GO:0016021//GO:0016012//GO:0016020 integral component of membrane//sarcoglycan complex//membrane KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.38486 BF_2 502.75 7.27 3182 91076670 XP_971562.1 2416 1.5e-269 PREDICTED: ATP-binding cassette sub-family F member 1 [Tribolium castaneum]>gi|270002367|gb|EEZ98814.1| hypothetical protein TcasGA2_TC004420 [Tribolium castaneum] 195480796 XM_002101360.1 253 3.28782e-127 Drosophila yakuba GE15656 (Dyak\GE15656), partial mRNA K06184 ABCF1 ATP-binding cassette, subfamily F, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06184 Q767L0 1764 2.4e-195 ATP-binding cassette sub-family F member 1 OS=Sus scrofa GN=ABCF1 PE=3 SV=1 PF00910//PF01637//PF03266//PF03193//PF00005//PF00448//PF00931//PF06003//PF02367//PF01008//PF07213//PF00004//PF13304//PF01926//PF07728//PF08477//PF00488 RNA helicase//Archaeal ATPase//NTPase//Protein of unknown function, DUF258//ABC transporter//SRP54-type protein, GTPase domain//NB-ARC domain//Survival motor neuron protein (SMN)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Initiation factor 2 subunit family//DAP10 membrane protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//MutS domain V GO:0007264//GO:0002949//GO:0006298//GO:0014068//GO:0006397//GO:0050776//GO:0006200//GO:0044237//GO:0007165//GO:0006614 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//mismatch repair//positive regulation of phosphatidylinositol 3-kinase signaling//mRNA processing//regulation of immune response//obsolete ATP catabolic process//cellular metabolic process//signal transduction//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0005525//GO:0043531//GO:0003723//GO:0030983//GO:0005102//GO:0016887//GO:0043548//GO:0003924//GO:0005524//GO:0098519 RNA helicase activity//GTP binding//ADP binding//RNA binding//mismatched DNA binding//receptor binding//ATPase activity//phosphatidylinositol 3-kinase binding//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides GO:0016020//GO:0005634//GO:0005737 membrane//nucleus//cytoplasm KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.38490 BF_2 66.14 1.33 2365 91078958 XP_974220.1 498 2.8e-47 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 642916228 XM_969127.2 108 9.81065e-47 PREDICTED: Tribolium castaneum cathepsin B precursor (LOC663066), transcript variant X2, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P43233 394 1.3e-36 Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1 PF08127//PF00112 Peptidase family C1 propeptide//Papain family cysteine protease GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.38491 BF_2 791.55 14.67 2545 478260090 ENN79875.1 1710 8.6e-188 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 3.99411e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1414 7.4e-155 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006012//GO:0006098//GO:0006096//GO:0006000//GO:0006013//GO:0006094 galactose metabolic process//pentose-phosphate shunt//glycolytic process//fructose metabolic process//mannose metabolic process//gluconeogenesis GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.38493 BF_2 83.45 0.42 8553 157106769 XP_001649474.1 419 1.4e-37 AAEL014742-PA, partial [Aedes aegypti]>gi|108868779|gb|EAT33004.1| AAEL014742-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q28F51 689 2.9e-70 TAR DNA-binding protein 43 OS=Xenopus tropicalis GN=tardbp PE=2 SV=1 PF15750//PF00096//PF07776//PF13606//PF16367//PF00076//PF13465//PF00023//PF16622//PF02892//PF13912 Ubiquitin-binding zinc-finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Ankyrin repeat//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc-finger double domain//Ankyrin repeat//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0003676//GO:0003677//GO:0008270//GO:0043130//GO:0005515//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//ubiquitin binding//protein binding//metal ion binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.38494 BF_2 2992.03 16.10 8060 157106769 XP_001649474.1 419 1.4e-37 AAEL014742-PA, partial [Aedes aegypti]>gi|108868779|gb|EAT33004.1| AAEL014742-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q28F51 957 2.3e-101 TAR DNA-binding protein 43 OS=Xenopus tropicalis GN=tardbp PE=2 SV=1 PF15750//PF00096//PF07776//PF13606//PF16367//PF00076//PF03104//PF13465//PF00023//PF16622//PF02892//PF13912 Ubiquitin-binding zinc-finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Ankyrin repeat//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//DNA polymerase family B, exonuclease domain//Zinc-finger double domain//Ankyrin repeat//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003676//GO:0008408//GO:0008270//GO:0005515//GO:0003677//GO:0043130 metal ion binding//nucleic acid binding//3'-5' exonuclease activity//zinc ion binding//protein binding//DNA binding//ubiquitin binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.38495 BF_2 48.00 1.10 2115 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38496 BF_2 203.79 1.92 4731 478262128 ENN81013.1 3533 0.0e+00 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 529 5.8e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38497 BF_2 717.25 30.84 1260 332376436 AEE63358.1 857 3.4e-89 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 526 3.4e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38498 BF_2 1338.99 13.44 4454 478262128 ENN81013.1 3533 0.0e+00 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 529 5.4e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- KOG0245 Kinesin-like protein Cluster-8309.38501 BF_2 83.88 0.65 5705 642931136 XP_967600.2 3863 0.0e+00 PREDICTED: DNA-directed RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270012086|gb|EFA08534.1| hypothetical protein TcasGA2_TC006188 [Tribolium castaneum] -- -- -- -- -- K10908 POLRMT, RPO41 DNA-directed RNA polymerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K10908 Q8BKF1 1977 8.7e-220 DNA-directed RNA polymerase, mitochondrial OS=Mus musculus GN=Polrmt PE=2 SV=1 PF00940//PF03840 DNA-dependent RNA polymerase//Preprotein translocase SecG subunit GO:0006206//GO:0015031//GO:0006351//GO:0006144//GO:0009306 pyrimidine nucleobase metabolic process//protein transport//transcription, DNA-templated//purine nucleobase metabolic process//protein secretion GO:0015450//GO:0003899//GO:0003677//GO:0016740 P-P-bond-hydrolysis-driven protein transmembrane transporter activity//DNA-directed RNA polymerase activity//DNA binding//transferase activity GO:0005730//GO:0009941//GO:0016021 nucleolus//chloroplast envelope//integral component of membrane KOG1038 Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation Cluster-8309.38502 BF_2 670.48 4.30 6808 189240413 XP_969795.2 2222 9.8e-247 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 186 1.24383e-89 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 Q01167 1019 1.3e-108 Forkhead box protein K2 OS=Homo sapiens GN=FOXK2 PE=1 SV=3 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.38503 BF_2 21.01 0.73 1492 546672637 ERL84433.1 726 6.3e-74 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6UXY8 346 3.0e-31 Transmembrane channel-like protein 5 OS=Homo sapiens GN=TMC5 PE=2 SV=3 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.38504 BF_2 359.00 13.09 1434 478257422 ENN77578.1 556 3.1e-54 hypothetical protein YQE_05874, partial [Dendroctonus ponderosae]>gi|546685701|gb|ERL95162.1| hypothetical protein D910_12431 [Dendroctonus ponderosae] -- -- -- -- -- K15306 RANBP1 Ran-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15306 Q3T0M7 405 4.2e-38 Ran-specific GTPase-activating protein OS=Bos taurus GN=RANBP1 PE=2 SV=1 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.38505 BF_2 152.43 1.71 4015 642926470 XP_008191971.1 1644 6.1e-180 PREDICTED: flotillin-2 isoform X1 [Tribolium castaneum] 645037638 XM_008207769.1 344 1.07721e-177 PREDICTED: Nasonia vitripennis flotillin-2 (LOC103316081), mRNA K07192 FLOT flotillin http://www.genome.jp/dbget-bin/www_bget?ko:K07192 O61492 1513 3.9e-166 Flotillin-2 OS=Drosophila melanogaster GN=Flo-2 PE=2 SV=3 PF12052 Voltage gated calcium channel subunit beta domain 4Aa N terminal GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005245 voltage-gated calcium channel activity GO:0005891 voltage-gated calcium channel complex -- -- Cluster-8309.38506 BF_2 642.57 6.95 4157 91076824 XP_967870.1 1208 2.3e-129 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 729 3.3e-75 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.38507 BF_2 265.00 2.51 4708 642911698 XP_008200706.1 1667 1.5e-182 PREDICTED: uncharacterized protein CG10915 isoform X1 [Tribolium castaneum] 642911699 XM_008202485.1 290 1.31967e-147 PREDICTED: Tribolium castaneum uncharacterized protein CG10915 (LOC658989), transcript variant X2, mRNA -- -- -- -- Q8SX68 804 7.4e-84 Uncharacterized protein CG10915 OS=Drosophila melanogaster GN=CG10915 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1103 Predicted coiled-coil protein Cluster-8309.38509 BF_2 186.28 3.73 2377 91077452 XP_967401.1 1566 4.0e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.3e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF00106//PF01370//PF13676 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//TIR domain GO:0008152//GO:0007165//GO:0055114 metabolic process//signal transduction//oxidation-reduction process GO:0005515//GO:0016491//GO:0003824//GO:0050662//GO:0000166 protein binding//oxidoreductase activity//catalytic activity//coenzyme binding//nucleotide binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.3851 BF_2 2.00 1.00 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38510 BF_2 273.00 96.03 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38514 BF_2 5392.78 26.06 8943 642930696 XP_008199991.1 1575 1.4e-171 PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930698|ref|XP_008199992.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930700|ref|XP_008199993.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|270012671|gb|EFA09119.1| hypothetical protein TcasGA2_TC015979 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11883 1236 1.1e-133 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Rattus norvegicus GN=Aldh3a1 PE=1 SV=3 PF00171//PF07690//PF02558//PF08656//PF01370//PF00106 Aldehyde dehydrogenase family//Major Facilitator Superfamily//Ketopantoate reductase PanE/ApbA//DASH complex subunit Dad3//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0015940//GO:0055085//GO:0006096//GO:0006570//GO:0006558//GO:0006094//GO:0008608//GO:0055114//GO:0008152//GO:0006081//GO:0006547 pantothenate biosynthetic process//transmembrane transport//glycolytic process//tyrosine metabolic process//L-phenylalanine metabolic process//gluconeogenesis//attachment of spindle microtubules to kinetochore//oxidation-reduction process//metabolic process//cellular aldehyde metabolic process//histidine metabolic process GO:0050662//GO:0003824//GO:0016491//GO:0008677//GO:0004030 coenzyme binding//catalytic activity//oxidoreductase activity//2-dehydropantoate 2-reductase activity//aldehyde dehydrogenase [NAD(P)+] activity GO:0016021//GO:0042729//GO:0072686 integral component of membrane//DASH complex//mitotic spindle KOG2456 Aldehyde dehydrogenase Cluster-8309.38515 BF_2 6784.36 47.76 6230 91086811 XP_973640.1 2901 0.0e+00 PREDICTED: tetratricopeptide repeat protein 30A [Tribolium castaneum]>gi|270009704|gb|EFA06152.1| hypothetical protein TcasGA2_TC008997 [Tribolium castaneum] 665813619 XM_008557152.1 150 1.17086e-69 PREDICTED: Microplitis demolitor tetratricopeptide repeat protein 30A (LOC103576769), mRNA -- -- -- -- A4IHR1 2294 1.6e-256 Tetratricopeptide repeat protein 30A OS=Xenopus tropicalis GN=ttc30a PE=2 SV=1 PF13181//PF13174//PF00031//PF00112//PF00515//PF13414//PF00333//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Cystatin domain//Papain family cysteine protease//Tetratricopeptide repeat//TPR repeat//Ribosomal protein S5, N-terminal domain//Tetratricopeptide repeat GO:0006412//GO:0006508//GO:0042254 translation//proteolysis//ribosome biogenesis GO:0003723//GO:0004869//GO:0005515//GO:0003735//GO:0008234 RNA binding//cysteine-type endopeptidase inhibitor activity//protein binding//structural constituent of ribosome//cysteine-type peptidase activity GO:0005840 ribosome KOG1542 Cysteine proteinase Cathepsin F Cluster-8309.38517 BF_2 5095.00 461.49 749 478253250 ENN73621.1 690 4.7e-70 hypothetical protein YQE_09868, partial [Dendroctonus ponderosae]>gi|546676347|gb|ERL87374.1| hypothetical protein D910_04769 [Dendroctonus ponderosae] 667677333 AE014297.3 68 5.18396e-25 Drosophila melanogaster chromosome 3R K02138 ATPeF0D, ATP5H, ATP7 F-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02138 Q24251 589 1.0e-59 ATP synthase subunit d, mitochondrial OS=Drosophila melanogaster GN=ATPsyn-d PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3366 Mitochondrial F1F0-ATP synthase, subunit d/ATP7 Cluster-8309.38518 BF_2 26017.99 202.38 5665 393010342 AFN02498.1 2025 5.7e-224 heat shock protein 90 [Tenebrio molitor] 570341957 KC620427.1 918 0 Lissorhoptrus oryzophilus heat shock protein 90 (HSP90b) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q9BLC5 1942 9.8e-216 Heat shock protein 83 OS=Bombyx mori GN=Hsp83 PE=1 SV=1 PF04857//PF11605//PF10510//PF00183 CAF1 family ribonuclease//Vacuolar protein sorting protein 36 Vps36//Phosphatidylinositol-glycan biosynthesis class S protein//Hsp90 protein GO:0006950//GO:0006457//GO:0016255 response to stress//protein folding//attachment of GPI anchor to protein GO:0005524//GO:0043130//GO:0051082//GO:0032266 ATP binding//ubiquitin binding//unfolded protein binding//phosphatidylinositol-3-phosphate binding GO:0005634//GO:0042765 nucleus//GPI-anchor transamidase complex KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.38520 BF_2 2483.30 18.53 5892 769847492 XP_011635083.1 2338 3.0e-260 PREDICTED: EH domain-containing protein 3 isoform X1 [Pogonomyrmex barbatus] 462311205 APGK01047050.1 382 0 Dendroctonus ponderosae Seq01047060, whole genome shotgun sequence K12483 EHD1 EH domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12483 Q5RBP4 1964 2.9e-218 EH domain-containing protein 1 OS=Pongo abelii GN=EHD1 PE=2 SV=1 PF02421//PF12763//PF01926//PF13833//PF13405//PF08477//PF02392//PF13499//PF13202//PF04548//PF04670//PF02367//PF00782//PF03193//PF00036 Ferrous iron transport protein B//Cytoskeletal-regulatory complex EF hand//50S ribosome-binding GTPase//EF-hand domain pair//EF-hand domain//Ras of Complex, Roc, domain of DAPkinase//Ycf4//EF-hand domain pair//EF hand//AIG1 family//Gtr1/RagA G protein conserved region//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dual specificity phosphatase, catalytic domain//Protein of unknown function, DUF258//EF hand GO:0002949//GO:0015684//GO:0007264//GO:0015979//GO:0006470 tRNA threonylcarbamoyladenosine modification//ferrous iron transport//small GTPase mediated signal transduction//photosynthesis//protein dephosphorylation GO:0005509//GO:0005525//GO:0015093//GO:0003924//GO:0008138//GO:0005515 calcium ion binding//GTP binding//ferrous iron transmembrane transporter activity//GTPase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding GO:0009579//GO:0016021//GO:0009522 thylakoid//integral component of membrane//photosystem I -- -- Cluster-8309.38522 BF_2 35.43 0.42 3798 189241141 XP_973953.2 1608 8.6e-176 PREDICTED: probable isocitrate dehydrogenase [NAD] subunit beta, mitochondrial [Tribolium castaneum]>gi|270013913|gb|EFA10361.1| hypothetical protein TcasGA2_TC012587 [Tribolium castaneum] 768410303 XM_011559102.1 281 1.07017e-142 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67827 1103 1.3e-118 Casein kinase I isoform alpha OS=Bos taurus GN=CSNK1A1 PE=1 SV=1 PF05445//PF00180//PF07850//PF00069//PF07714 Poxvirus serine/threonine protein kinase//Isocitrate/isopropylmalate dehydrogenase//Renin receptor-like protein//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0007165//GO:0055114//GO:0006099 protein phosphorylation//signal transduction//oxidation-reduction process//tricarboxylic acid cycle GO:0004872//GO:0051287//GO:0016616//GO:0005524//GO:0004449//GO:0004672//GO:0000287 receptor activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//ATP binding//isocitrate dehydrogenase (NAD+) activity//protein kinase activity//magnesium ion binding GO:0016021 integral component of membrane KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.38523 BF_2 1251.64 19.52 2969 478257812 ENN77955.1 419 5.0e-38 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0001522//GO:0042254 cellular protein modification process//pseudouridine synthesis//ribosome biogenesis GO:0030515//GO:0016151 snoRNA binding//nickel cation binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.38525 BF_2 14.60 0.78 1067 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38526 BF_2 70584.26 1585.91 2149 73921486 AAZ94273.1 2434 8.1e-272 cytochrome P450 [Leptinotarsa decemlineata] 73921485 DQ117464.1 404 0 Leptinotarsa decemlineata cytochrome P450 (CYP4G29) mRNA, complete cds K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 Q9VYY4 1879 7.5e-209 Cytochrome P450 4g15 OS=Drosophila melanogaster GN=Cyp4g15 PE=2 SV=1 PF00762//PF00067 Ferrochelatase//Cytochrome P450 GO:0015994//GO:0006783//GO:0055114 chlorophyll metabolic process//heme biosynthetic process//oxidation-reduction process GO:0020037//GO:0005506//GO:0016705//GO:0004325 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//ferrochelatase activity -- -- -- -- Cluster-8309.38527 BF_2 59.44 1.23 2311 642930886 XP_008196126.1 427 4.6e-39 PREDICTED: myb-like protein X isoform X6 [Tribolium castaneum] 642930891 XM_008197907.1 97 1.24848e-40 PREDICTED: Tribolium castaneum protein-methionine sulfoxide oxidase MICAL3 (LOC658955), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38528 BF_2 4125.03 29.05 6228 91087897 XP_970459.1 859 1.0e-88 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270012016|gb|EFA08464.1| hypothetical protein TcasGA2_TC006113 [Tribolium castaneum] 642930872 XM_965366.2 96 1.22124e-39 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 1.4e-16 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF05495 CHY zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.38529 BF_2 1418.05 20.64 3161 642927459 XP_968905.2 858 6.6e-89 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 563 4.4e-56 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF02879//PF00107 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Zinc-binding dehydrogenase GO:0005975//GO:0055114 carbohydrate metabolic process//oxidation-reduction process -- -- -- -- -- -- Cluster-8309.38530 BF_2 7.00 0.52 852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38532 BF_2 1081.20 10.11 4759 270008035 EFA04483.1 1785 3.2e-196 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q14155 928 3.1e-98 Rho guanine nucleotide exchange factor 7 OS=Homo sapiens GN=ARHGEF7 PE=1 SV=2 PF10280//PF00018//PF14604//PF00621 Mediator complex protein//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023//GO:0006357 regulation of GTPase activity//regulation of Rho protein signal transduction//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0005515//GO:0005089 RNA polymerase II transcription cofactor activity//protein binding//Rho guanyl-nucleotide exchange factor activity GO:0016592 mediator complex KOG2070 Guanine nucleotide exchange factor Cluster-8309.38535 BF_2 5699.30 137.51 2021 270004992 EFA01440.1 2223 2.2e-247 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] 242022531 XM_002431649.1 134 2.94443e-61 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- Q9I7U4 1530 2.1e-168 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38536 BF_2 78.96 3.67 1186 642912101 XP_008200805.1 1567 1.5e-171 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [Tribolium castaneum] 665820405 XM_008560879.1 303 1.92981e-155 PREDICTED: Microplitis demolitor V-type proton ATPase 116 kDa subunit a isoform 1 (LOC103579473), mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9Z1G4 1193 1.5e-129 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Mus musculus GN=Atp6v0a1 PE=1 SV=3 PF04111//PF00769//PF01496 Autophagy protein Apg6//Ezrin/radixin/moesin family//V-type ATPase 116kDa subunit family GO:0006914//GO:0015991//GO:0015992 autophagy//ATP hydrolysis coupled proton transport//proton transport GO:0008092//GO:0015078 cytoskeletal protein binding//hydrogen ion transmembrane transporter activity GO:0019898//GO:0033179//GO:0005737 extrinsic component of membrane//proton-transporting V-type ATPase, V0 domain//cytoplasm KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.38537 BF_2 48.79 0.38 5609 642926232 XP_008194839.1 846 2.9e-87 PREDICTED: transcriptional activator protein Pur-alpha isoform X2 [Tribolium castaneum] 642926231 XM_008196617.1 95 3.95325e-39 PREDICTED: Tribolium castaneum transcriptional activator protein Pur-alpha (LOC662482), transcript variant X2, mRNA -- -- -- -- Q00577 372 1.1e-33 Transcriptional activator protein Pur-alpha OS=Homo sapiens GN=PURA PE=1 SV=2 PF09284 Rhamnogalacturonan lyase B, N-terminal GO:0005975 carbohydrate metabolic process GO:0030246//GO:0016837 carbohydrate binding//carbon-oxygen lyase activity, acting on polysaccharides -- -- KOG3074 Transcriptional regulator of the PUR family, single-stranded-DNA-binding Cluster-8309.38539 BF_2 619.43 2.93 9135 642933138 XP_008197272.1 7873 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 13 isoform X1 [Tribolium castaneum] 642933139 XM_008199051.1 239 5.76124e-119 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 13 (LOC662491), transcript variant X2, mRNA K15164 MED13 mediator of RNA polymerase II transcription subunit 13 http://www.genome.jp/dbget-bin/www_bget?ko:K15164 Q7KTX8 2103 3.4e-234 Mediator of RNA polymerase II transcription subunit 13 OS=Drosophila melanogaster GN=skd PE=1 SV=1 PF02671//PF06333//PF10501 Paired amphipathic helix repeat//Mediator complex subunit 13 C-terminal//Ribosomal subunit 39S GO:0006355//GO:0006357 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005739 mediator complex//mitochondrion KOG3600 Thyroid hormone receptor-associated protein complex, subunit TRAP240 Cluster-8309.38542 BF_2 146.43 1.28 5078 91095163 XP_968103.1 3134 0.0e+00 PREDICTED: phosphorylated CTD-interacting factor 1 [Tribolium castaneum]>gi|270015787|gb|EFA12235.1| hypothetical protein TcasGA2_TC004110 [Tribolium castaneum] -- -- -- -- -- K17584 PCIF1 phosphorylated CTD-interacting factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17584 Q9H4Z3 1532 3.1e-168 Phosphorylated CTD-interacting factor 1 OS=Homo sapiens GN=PCIF1 PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38544 BF_2 5063.67 20.22 10761 642916043 XP_008190869.1 3028 0.0e+00 PREDICTED: ras-GEF domain-containing family member 1B-like isoform X1 [Tribolium castaneum] 808119259 XM_012307759.1 168 1.99807e-79 PREDICTED: Bombus terrestris ras-GEF domain-containing family member 1B-like (LOC100645439), transcript variant X2, mRNA -- -- -- -- Q6DHR3 1300 5.2e-141 Ras-GEF domain-containing family member 1B-A OS=Danio rerio GN=rasgef1ba PE=2 SV=2 PF00617//PF00412//PF02209//PF13639 RasGEF domain//LIM domain//Villin headpiece domain//Ring finger domain GO:0007264//GO:0007010//GO:0043087 small GTPase mediated signal transduction//cytoskeleton organization//regulation of GTPase activity GO:0005515//GO:0003779//GO:0005085//GO:0008270 protein binding//actin binding//guanyl-nucleotide exchange factor activity//zinc ion binding -- -- KOG3541 Predicted guanine nucleotide exchange factor Cluster-8309.38545 BF_2 13.00 2.80 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38546 BF_2 1838.18 10.40 7678 642923618 XP_008193579.1 8967 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: dedicator of cytokinesis protein 9 [Tribolium castaneum] 815808572 XM_012369703.1 116 1.14827e-50 PREDICTED: Linepithema humile dedicator of cytokinesis protein 9 (LOC105673797), transcript variant X4, mRNA -- -- -- -- Q9BZ29 4203 0.0e+00 Dedicator of cytokinesis protein 9 OS=Homo sapiens GN=DOCK9 PE=1 SV=2 PF02183//PF03810 Homeobox associated leucine zipper//Importin-beta N-terminal domain GO:0006886//GO:0006355 intracellular protein transport//regulation of transcription, DNA-templated GO:0003700//GO:0008536//GO:0043565 transcription factor activity, sequence-specific DNA binding//Ran GTPase binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG1997 PH domain-containing protein Cluster-8309.38547 BF_2 216.21 14.47 912 166851824 NP_001107778.1 400 2.4e-36 cuticular protein analogous to peritrophins 3-C5 isoform 2 precursor [Tribolium castaneum]>gi|119387890|gb|ABL73930.1| obstractor C2 [Tribolium castaneum] 780672324 XM_011697243.1 79 4.88634e-31 PREDICTED: Wasmannia auropunctata uncharacterized LOC105454569 (LOC105454569), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.38548 BF_2 21.00 0.58 1797 695189911 AIT11911.1 1772 3.9e-195 endo-beta-1,4-glucanase [Parasesarma erythrodactyla] 292683084 AK339636.1 45 7.79569e-12 Lotus japonicus cDNA, clone: LjFL3-041-DF07, HTC -- -- -- -- P26221 966 4.7e-103 Endoglucanase E-4 OS=Thermobifida fusca GN=celD PE=1 SV=2 PF00759 Glycosyl hydrolase family 9 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.38549 BF_2 1107.03 13.01 3846 755975568 XP_011307696.1 271 9.4e-21 PREDICTED: phospholipase A1-like [Fopius arisanus] -- -- -- -- -- -- -- -- -- Q9BDJ4 216 9.2e-16 Lipase member H OS=Oryctolagus cuniculus GN=LIPH PE=2 SV=1 PF03494//PF00975 Beta-amyloid peptide (beta-APP)//Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds GO:0016021 integral component of membrane -- -- Cluster-8309.38551 BF_2 707.00 12.37 2678 91093142 XP_969809.1 3019 0.0e+00 PREDICTED: cell division cycle protein 27 homolog [Tribolium castaneum]>gi|270003019|gb|EEZ99466.1| hypothetical protein TcasGA2_TC000032 [Tribolium castaneum] -- -- -- -- -- K03350 APC3, CDC27 anaphase-promoting complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03350 A7Z061 1579 5.7e-174 Cell division cycle protein 27 homolog OS=Bos taurus GN=CDC27 PE=2 SV=1 PF13181//PF13174//PF13374//PF00515//PF13371//PF13414//PF01139//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//tRNA-splicing ligase RtcB//Tetratricopeptide repeat GO:0006396 RNA processing GO:0005515//GO:0008452 protein binding//RNA ligase activity -- -- KOG1126 DNA-binding cell division cycle control protein Cluster-8309.38553 BF_2 61.86 0.59 4640 820239016 BAR72977.1 1896 4.2e-209 cytochrome P450 15A1 [Tribolium castaneum] -- -- -- -- -- K14937 CYP15A1_C1 methyl farnesoate epoxidase / farnesoate epoxidase http://www.genome.jp/dbget-bin/www_bget?ko:K14937 Q6R7M4 1374 5.9e-150 Methyl farnesoate epoxidase OS=Diploptera punctata GN=CYP15A1 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.38555 BF_2 3199.00 69.27 2219 146411532 ABQ39970.1 2682 1.5e-300 heat shock protein 70 [Anatolica polita borealis] 402235128 JQ693015.1 483 0 Plutella xylostella Hsp72-1a mRNA, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 O97125 2454 1.6e-275 Heat shock protein 68 OS=Drosophila melanogaster GN=Hsp68 PE=1 SV=1 PF09326//PF06723//PF02782//PF01968 NADH-ubiquinone oxidoreductase subunit G, C-terminal//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//Hydantoinase/oxoprolinase GO:0055114//GO:0005975//GO:0000902 oxidation-reduction process//carbohydrate metabolic process//cell morphogenesis GO:0016651//GO:0016773//GO:0051536//GO:0016787 oxidoreductase activity, acting on NAD(P)H//phosphotransferase activity, alcohol group as acceptor//iron-sulfur cluster binding//hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.38556 BF_2 1300.79 10.94 5260 2654204 AAC63079.1 1031 9.6e-109 putative juvenile hormone esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020//PF03945 Ribosomal L40e family//delta endotoxin, N-terminal domain GO:0006412//GO:0042254//GO:0009405 translation//ribosome biogenesis//pathogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.38558 BF_2 1.00 0.31 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38560 BF_2 2320.05 27.86 3771 282165741 NP_001164113.1 2645 4.8e-296 cap-n-collar [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 5.4e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF03131//PF03126//PF07716//PF00170 bZIP Maf transcription factor//Plus-3 domain//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3863 bZIP transcription factor NRF1 Cluster-8309.38562 BF_2 5.05 0.38 848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38564 BF_2 508.60 7.33 3190 270012994 EFA09442.1 794 1.8e-81 hypothetical protein TcasGA2_TC010657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38565 BF_2 8.00 0.91 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38566 BF_2 286.71 4.74 2817 642923441 XP_008193745.1 2035 2.0e-225 PREDICTED: intraflagellar transport protein 80 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2H3 1238 2.1e-134 Intraflagellar transport protein 80 homolog OS=Homo sapiens GN=IFT80 PE=1 SV=3 PF04421//PF01239 Mss4 protein//Protein prenyltransferase alpha subunit repeat GO:0018342//GO:0043087//GO:0007264 protein prenylation//regulation of GTPase activity//small GTPase mediated signal transduction GO:0008318//GO:0005085 protein prenyltransferase activity//guanyl-nucleotide exchange factor activity -- -- KOG0529 Protein geranylgeranyltransferase type II, alpha subunit Cluster-8309.38567 BF_2 75.73 1.08 3218 478263360 ENN81736.1 393 5.6e-35 hypothetical protein YQE_01875, partial [Dendroctonus ponderosae]>gi|546681308|gb|ERL91422.1| hypothetical protein D910_08754 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04042 DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0003887 DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.38569 BF_2 48.95 0.81 2815 642928048 XP_008200135.1 909 7.2e-95 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 2.6e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04986//PF00038//PF04508//PF10473//PF01008//PF09392 Putative transposase//Intermediate filament protein//Viral A-type inclusion protein repeat//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Initiation factor 2 subunit family//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0015031//GO:0044237//GO:0006313//GO:0016032//GO:0009405 protein transport//cellular metabolic process//transposition, DNA-mediated//viral process//pathogenesis GO:0004803//GO:0042803//GO:0045502//GO:0008134//GO:0005198//GO:0003677 transposase activity//protein homodimerization activity//dynein binding//transcription factor binding//structural molecule activity//DNA binding GO:0005882//GO:0005667//GO:0030286 intermediate filament//transcription factor complex//dynein complex -- -- Cluster-8309.38570 BF_2 2.00 11.72 248 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38571 BF_2 315.86 2.27 6113 478258440 ENN78530.1 458 3.1e-42 hypothetical protein YQE_05004, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478//PF01442//PF04210//PF02601 Prominin//Apolipoprotein A1/A4/E domain//Tetrahydromethanopterin S-methyltransferase, subunit G//Exonuclease VII, large subunit GO:0042157//GO:0015948//GO:0046656//GO:0006869//GO:0006308 lipoprotein metabolic process//methanogenesis//folic acid biosynthetic process//lipid transport//DNA catabolic process GO:0030269//GO:0008289//GO:0008855 tetrahydromethanopterin S-methyltransferase activity//lipid binding//exodeoxyribonuclease VII activity GO:0016021//GO:0005576//GO:0009318 integral component of membrane//extracellular region//exodeoxyribonuclease VII complex -- -- Cluster-8309.38572 BF_2 65.01 3.51 1062 189240524 XP_971875.2 535 6.3e-52 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] 808139336 XM_003400646.2 152 1.50316e-71 PREDICTED: Bombus terrestris 60S ribosomal protein L3 (LOC100646559), mRNA K02925 RP-L3e, RPL3 large subunit ribosomal protein L3e http://www.genome.jp/dbget-bin/www_bget?ko:K02925 O16797 487 9.6e-48 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 PF00297 Ribosomal protein L3 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.38573 BF_2 40.00 2.05 1102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38574 BF_2 39.00 0.78 2382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38579 BF_2 3715.36 10.66 14873 498980679 XP_004529416.1 18931 0.0e+00 PREDICTED: low-density lipoprotein receptor-related protein 2 [Ceratitis capitata]>gi|498980683|ref|XP_004529417.1| PREDICTED: low-density lipoprotein receptor-related protein 2 [Ceratitis capitata] 665794659 XM_008546814.1 316 1.47454e-161 PREDICTED: Microplitis demolitor low-density lipoprotein receptor-related protein 2 (LOC103569491), mRNA K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98158 9274 0.0e+00 Low-density lipoprotein receptor-related protein 2 OS=Rattus norvegicus GN=Lrp2 PE=1 SV=1 PF00008//PF07645//PF00057//PF09246//PF01731 EGF-like domain//Calcium-binding EGF domain//Low-density lipoprotein receptor domain class A//PHAT//Arylesterase GO:0006355 regulation of transcription, DNA-templated GO:0004064//GO:0005515//GO:0005509//GO:0003723 arylesterase activity//protein binding//calcium ion binding//RNA binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38581 BF_2 1435.18 5.88 10493 642917842 XP_008191308.1 2642 3.0e-295 PREDICTED: serine/threonine-protein kinase MARK2 isoform X6 [Tribolium castaneum] 642917841 XM_008193086.1 688 0 PREDICTED: Tribolium castaneum par-1 protein kinase (LOC656926), transcript variant X7, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 Q8VHJ5 1427 9.5e-156 Serine/threonine-protein kinase MARK1 OS=Mus musculus GN=Mark1 PE=1 SV=2 PF00069//PF06293//PF07714//PF00802 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Pneumovirus attachment glycoprotein G GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020//GO:0055036 membrane//virion membrane KOG0586 Serine/threonine protein kinase Cluster-8309.38582 BF_2 1813.03 8.32 9399 642917848 XP_008191311.1 2512 3.2e-280 PREDICTED: serine/threonine-protein kinase MARK2 isoform X9 [Tribolium castaneum] 642917841 XM_008193086.1 688 0 PREDICTED: Tribolium castaneum par-1 protein kinase (LOC656926), transcript variant X7, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 Q8VHJ5 1427 8.5e-156 Serine/threonine-protein kinase MARK1 OS=Mus musculus GN=Mark1 PE=1 SV=2 PF00802//PF07714//PF04310//PF06293//PF00069 Pneumovirus attachment glycoprotein G//Protein tyrosine kinase//MukB N-terminal//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0030261//GO:0007059//GO:0006468 chromosome condensation//chromosome segregation//protein phosphorylation GO:0004672//GO:0016773//GO:0003677//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//DNA binding//ATP binding GO:0016020//GO:0009295//GO:0055036 membrane//nucleoid//virion membrane KOG0586 Serine/threonine protein kinase Cluster-8309.38583 BF_2 62.83 0.42 6608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.38585 BF_2 18.58 1.53 796 332375004 AEE62643.1 598 2.4e-59 unknown [Dendroctonus ponderosae]>gi|478258425|gb|ENN78519.1| hypothetical protein YQE_05012, partial [Dendroctonus ponderosae]>gi|546676434|gb|ERL87445.1| hypothetical protein D910_04837 [Dendroctonus ponderosae] -- -- -- -- -- K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P80971 268 1.8e-22 Cytochrome c oxidase subunit 4 isoform 2, mitochondrial OS=Thunnus obesus PE=1 SV=2 PF02936 Cytochrome c oxidase subunit IV GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG4075 Cytochrome c oxidase, subunit IV/COX5b Cluster-8309.38586 BF_2 597.03 5.23 5067 91087225 XP_975488.1 2701 2.1e-302 PREDICTED: N-terminal kinase-like protein [Tribolium castaneum] 642929977 XM_970395.2 495 0 PREDICTED: Tribolium castaneum N-terminal kinase-like protein (LOC664388), mRNA K08876 SCYL1 SCY1-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08876 Q28FH2 1597 8.9e-176 N-terminal kinase-like protein OS=Xenopus tropicalis GN=scyl1 PE=2 SV=1 PF01602//PF07714//PF00069//PF02985 Adaptin N terminal region//Protein tyrosine kinase//Protein kinase domain//HEAT repeat GO:0006886//GO:0016192//GO:0006468 intracellular protein transport//vesicle-mediated transport//protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0030117 membrane coat KOG1243 Protein kinase Cluster-8309.38588 BF_2 1028.86 3.21 13689 478254656 ENN74897.1 12128 0.0e+00 hypothetical protein YQE_08475, partial [Dendroctonus ponderosae] 611970121 XM_007480100.1 108 5.74467e-46 PREDICTED: Monodelphis domestica HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), mRNA K10594 HERC1 E3 ubiquitin-protein ligase HERC1 http://www.genome.jp/dbget-bin/www_bget?ko:K10594 Q15751 3927 0.0e+00 Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens GN=HERC1 PE=1 SV=2 PF06817//PF00400//PF01475//PF00632//PF00622 Reverse transcriptase thumb domain//WD domain, G-beta repeat//Ferric uptake regulator family//HECT-domain (ubiquitin-transferase)//SPRY domain GO:0006355//GO:0016567//GO:0006278 regulation of transcription, DNA-templated//protein ubiquitination//RNA-dependent DNA replication GO:0003700//GO:0005515//GO:0004842//GO:0003964 transcription factor activity, sequence-specific DNA binding//protein binding//ubiquitin-protein transferase activity//RNA-directed DNA polymerase activity GO:0005667 transcription factor complex KOG1426 FOG: RCC1 domain Cluster-8309.38589 BF_2 48.66 0.48 4539 91077758 XP_967802.1 1416 1.9e-153 PREDICTED: fructose-1,6-bisphosphatase 1 [Tribolium castaneum]>gi|270002228|gb|EEZ98675.1| hypothetical protein TcasGA2_TC001209 [Tribolium castaneum] 229367525 BT083036.1 55 5.49851e-17 Anoplopoma fimbria clone afim-evh-526-250 Fructose-1,6-bisphosphatase 1 putative mRNA, complete cds K03841 FBP, fbp fructose-1,6-bisphosphatase I http://www.genome.jp/dbget-bin/www_bget?ko:K03841 Q3SZB7 1017 1.4e-108 Fructose-1,6-bisphosphatase 1 OS=Bos taurus GN=FBP1 PE=2 SV=3 PF00316//PF00459//PF13181//PF00515//PF13414//PF13174 Fructose-1-6-bisphosphatase//Inositol monophosphatase family//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006098//GO:0006096//GO:0015976//GO:0006094//GO:0005975//GO:0006000//GO:0046854//GO:0006013 pentose-phosphate shunt//glycolytic process//carbon utilization//gluconeogenesis//carbohydrate metabolic process//fructose metabolic process//phosphatidylinositol phosphorylation//mannose metabolic process GO:0042132//GO:0005515//GO:0042578 fructose 1,6-bisphosphate 1-phosphatase activity//protein binding//phosphoric ester hydrolase activity -- -- KOG1458 Fructose-1,6-bisphosphatase Cluster-8309.3859 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38590 BF_2 258.00 9.47 1427 91085271 XP_967089.1 1437 2.2e-156 PREDICTED: GDP-L-fucose synthase [Tribolium castaneum]>gi|270008444|gb|EFA04892.1| hypothetical protein TcasGA2_TC014956 [Tribolium castaneum] -- -- -- -- -- K02377 TSTA3, fcl GDP-L-fucose synthase http://www.genome.jp/dbget-bin/www_bget?ko:K02377 Q8K3X2 1145 6.5e-124 GDP-L-fucose synthase OS=Cricetulus griseus GN=TSTA3 PE=2 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0044237//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//cellular metabolic process//estrogen metabolic process GO:0000166//GO:0016616//GO:0003824//GO:0050662//GO:0003854 nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1431 GDP-L-fucose synthetase Cluster-8309.38591 BF_2 329.48 1.92 7465 270012248 EFA08696.1 940 4.9e-98 hypothetical protein TcasGA2_TC006367 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q8IX06 586 2.2e-58 Putative exonuclease GOR OS=Homo sapiens GN=REXO1L1P PE=5 SV=2 PF02932//PF01612//PF00930//PF00400 Neurotransmitter-gated ion-channel transmembrane region//3'-5' exonuclease//Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006811//GO:0006139//GO:0006508 ion transport//nucleobase-containing compound metabolic process//proteolysis GO:0005515//GO:0008408//GO:0003676 protein binding//3'-5' exonuclease activity//nucleic acid binding GO:0016020 membrane KOG2248 3'-5' exonuclease Cluster-8309.38592 BF_2 1365.00 18.20 3424 642940096 XP_008192965.1 1556 8.3e-170 PREDICTED: paxillin isoform X6 [Tribolium castaneum]>gi|270016014|gb|EFA12462.1| hypothetical protein TcasGA2_TC010609 [Tribolium castaneum] 665811408 XM_008555945.1 200 1.02714e-97 PREDICTED: Microplitis demolitor leupaxin-like (LOC103575940), mRNA K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 P49024 851 1.9e-89 Paxillin OS=Gallus gallus GN=PXN PE=1 SV=1 PF04216//PF05923//PF00412 Protein involved in formate dehydrogenase formation//APC cysteine-rich region//LIM domain GO:0016055 Wnt signaling pathway GO:0008270//GO:0043169 zinc ion binding//cation binding GO:0005737 cytoplasm KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.38593 BF_2 18.26 0.41 2138 270005756 EFA02204.1 1090 5.6e-116 hypothetical protein TcasGA2_TC007862 [Tribolium castaneum] 642919215 XM_963943.3 240 3.70498e-120 PREDICTED: Tribolium castaneum uncharacterized LOC657485 (LOC657485), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38594 BF_2 14.26 1.99 587 270005756 EFA02204.1 409 1.4e-37 hypothetical protein TcasGA2_TC007862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38596 BF_2 5137.04 75.70 3126 642913083 XP_008201383.1 2737 8.6e-307 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.37579e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 2147 9.2e-240 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF14604//PF00018//PF13180 PDZ domain (Also known as DHR or GLGF)//Variant SH3 domain//SH3 domain//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.38600 BF_2 6.00 17.30 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38601 BF_2 1006.94 13.87 3325 91085925 XP_969990.1 570 1.7e-55 PREDICTED: charged multivesicular body protein 4b [Tribolium castaneum]>gi|270009953|gb|EFA06401.1| hypothetical protein TcasGA2_TC009279 [Tribolium castaneum] 827540193 XM_004923412.2 101 1.07782e-42 PREDICTED: Bombyx mori charged multivesicular body protein 4b (LOC101737568), mRNA K12194 CHMP4, SNF7, VPS32 charged multivesicular body protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12194 Q6IQ73 457 9.1e-44 Charged multivesicular body protein 4c OS=Danio rerio GN=chmp4c PE=2 SV=1 PF03357//PF01920//PF02993//PF00293//PF08707//PF04053//PF09177//PF00015 Snf7//Prefoldin subunit//Minor capsid protein VI//NUDIX domain//Primase C terminal 2 (PriCT-2)//Coatomer WD associated region//Syntaxin 6, N-terminal//Methyl-accepting chemotaxis protein (MCP) signalling domain GO:0006457//GO:0007165//GO:0006886//GO:0016192//GO:0048193//GO:0007034 protein folding//signal transduction//intracellular protein transport//vesicle-mediated transport//Golgi vesicle transport//vacuolar transport GO:0016787//GO:0005198//GO:0004871//GO:0051082//GO:0016817 hydrolase activity//structural molecule activity//signal transducer activity//unfolded protein binding//hydrolase activity, acting on acid anhydrides GO:0019028//GO:0016020//GO:0030117//GO:0016272 viral capsid//membrane//membrane coat//prefoldin complex KOG1656 Protein involved in glucose derepression and pre-vacuolar endosome protein sorting Cluster-8309.38603 BF_2 42.96 3.34 826 91080583 XP_973590.1 661 1.2e-66 PREDICTED: 60S ribosomal protein L27a [Tribolium castaneum]>gi|270005809|gb|EFA02257.1| hypothetical protein TcasGA2_TC007920 [Tribolium castaneum] 70909818 AM049096.1 177 1.46661e-85 Agriotes lineatus mRNA for ribosomal protein L27Ae (rpL27Ae gene) K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 Q27021 563 1.1e-56 60S ribosomal protein L27a OS=Tenebrio molitor GN=RpL27A PE=2 SV=1 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1742 60s ribosomal protein L15/L27 Cluster-8309.38605 BF_2 1147.47 18.62 2865 91078618 XP_967724.1 1634 6.3e-179 PREDICTED: cytochrome P450 4d2 [Tribolium castaneum]>gi|270004875|gb|EFA01323.1| cytochrome P450 4BR3 [Tribolium castaneum] 689542312 LL999114.1 35 4.53226e-06 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_contig0000050 K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 938 1.3e-99 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0016705 oxidoreductase activity//iron ion binding//metal ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.38606 BF_2 4582.00 44.81 4565 755986659 XP_011311259.1 4024 0.0e+00 PREDICTED: translation elongation factor 2 [Fopius arisanus] 194760510 XM_001962447.1 1137 0 Drosophila ananassae GF14422 (Dana\GF14422), mRNA K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3937 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF00983//PF01926 Elongation factor G, domain IV//Elongation factor Tu domain 2//Tymovirus coat protein//50S ribosome-binding GTPase -- -- GO:0005525//GO:0005198 GTP binding//structural molecule activity GO:0019028 viral capsid KOG0469 Elongation factor 2 Cluster-8309.38609 BF_2 217.93 1.37 6921 642925954 XP_008195644.1 2092 1.2e-231 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 1367 5.7e-149 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF00076//PF00309//PF01429//PF01400//PF01073//PF00642//PF03015//PF01480//PF01370 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sigma-54 factor, Activator interacting domain (AID)//Methyl-CpG binding domain//Astacin (Peptidase family M12A)//3-beta hydroxysteroid dehydrogenase/isomerase family//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Male sterility protein//PWI domain//NAD dependent epimerase/dehydratase family GO:0008210//GO:0006397//GO:0006351//GO:0006144//GO:0006206//GO:0006508//GO:0006352//GO:0008207//GO:0006355//GO:0008209//GO:0055114//GO:0006694 estrogen metabolic process//mRNA processing//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//proteolysis//DNA-templated transcription, initiation//C21-steroid hormone metabolic process//regulation of transcription, DNA-templated//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0003677//GO:0003824//GO:0003676//GO:0016987//GO:0046872//GO:0050662//GO:0003899//GO:0003854//GO:0004222//GO:0016616//GO:0080019//GO:0003700 DNA binding//catalytic activity//nucleic acid binding//sigma factor activity//metal ion binding//coenzyme binding//DNA-directed RNA polymerase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//metalloendopeptidase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005730 nucleus//transcription factor complex//nucleolus KOG1221 Acyl-CoA reductase Cluster-8309.38611 BF_2 5078.74 32.80 6765 642926040 XP_008194740.1 9411 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 852 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 6832 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF02655//PF02786//PF07478//PF08326 ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//Acetyl-CoA carboxylase, central region GO:0006090//GO:0009252//GO:0006633//GO:0046436 pyruvate metabolic process//peptidoglycan biosynthetic process//fatty acid biosynthetic process//D-alanine metabolic process GO:0003989//GO:0008716//GO:0046872//GO:0005524 acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity//metal ion binding//ATP binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.38612 BF_2 3373.04 31.97 4701 642931172 XP_008196469.1 2267 4.1e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38613 BF_2 236.50 3.80 2888 642915594 XP_008190680.1 519 1.2e-49 PREDICTED: uncharacterized protein LOC655748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02655//PF01077 ATP-grasp domain//Nitrite and sulphite reductase 4Fe-4S domain GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0020037//GO:0005524//GO:0051536 metal ion binding//oxidoreductase activity//heme binding//ATP binding//iron-sulfur cluster binding -- -- -- -- Cluster-8309.38614 BF_2 498.32 5.96 3785 642913883 XP_975200.2 1541 5.0e-168 PREDICTED: forkhead box protein O isoform X1 [Tribolium castaneum] 642913884 XM_008202979.1 252 1.40917e-126 PREDICTED: Tribolium castaneum forkhead box protein O (LOC664090), transcript variant X2, mRNA K09408 FOXO3 forkhead box protein O3 http://www.genome.jp/dbget-bin/www_bget?ko:K09408 B4MB78 905 1.2e-95 Forkhead box protein O OS=Drosophila virilis GN=foxo PE=3 SV=1 PF01342//PF00250 SAND domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.38615 BF_2 276.72 3.94 3226 332376929 AEE63604.1 1043 2.4e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05319 445 2.2e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38616 BF_2 3964.55 73.32 2549 332376929 AEE63604.1 1043 1.9e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05319 445 1.7e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38618 BF_2 141.84 3.81 1843 91081907 XP_970048.1 2043 1.5e-226 PREDICTED: myotubularin-related protein 9 isoform X2 [Tribolium castaneum]>gi|270007347|gb|EFA03795.1| hypothetical protein TcasGA2_TC013907 [Tribolium castaneum] -- -- -- -- -- K18084 MTMR9 myotubularin-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18084 Q96QG7 1404 7.8e-154 Myotubularin-related protein 9 OS=Homo sapiens GN=MTMR9 PE=1 SV=1 -- -- GO:0016311 dephosphorylation GO:0016791 phosphatase activity -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.38620 BF_2 162.66 2.25 3318 642929941 XP_008196035.1 1619 4.0e-177 PREDICTED: nucleolar protein 4-like isoform X3 [Tribolium castaneum] 817216939 XM_012429042.1 117 1.37174e-51 PREDICTED: Orussus abietinus nucleolar protein 4-like (LOC105701897), transcript variant X4, mRNA -- -- -- -- Q96MY1 448 1.0e-42 Nucleolar protein 4-like OS=Homo sapiens GN=NOL4L PE=1 SV=2 PF03607//PF09026 Doublecortin//Centromere protein B dimerisation domain GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0003682 DNA binding//chromatin binding GO:0005634//GO:0000785//GO:0000775 nucleus//chromatin//chromosome, centromeric region -- -- Cluster-8309.38621 BF_2 535.82 2.14 10763 270010025 EFA06473.1 8604 0.0e+00 hypothetical protein TcasGA2_TC009358 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.63484e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF09141//PF01025//PF01044//PF02174//PF01608 Talin, middle domain//GrpE//Vinculin family//PTB domain (IRS-1 type)//I/LWEQ domain GO:0007016//GO:0007165//GO:0006457//GO:0007155 cytoskeletal anchoring at plasma membrane//signal transduction//protein folding//cell adhesion GO:0003779//GO:0005158//GO:0005200//GO:0042803//GO:0051087//GO:0000774//GO:0051015 actin binding//insulin receptor binding//structural constituent of cytoskeleton//protein homodimerization activity//chaperone binding//adenyl-nucleotide exchange factor activity//actin filament binding GO:0005899//GO:0001726//GO:0005856//GO:0005925 insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.38625 BF_2 606.00 12.91 2251 91082293 XP_973907.1 1943 7.3e-215 PREDICTED: DEAD-box helicase Dbp80 [Tribolium castaneum]>gi|270007465|gb|EFA03913.1| hypothetical protein TcasGA2_TC014047 [Tribolium castaneum] -- -- -- -- -- K18655 DDX19, DBP5 ATP-dependent RNA helicase DDX19/DBP5 http://www.genome.jp/dbget-bin/www_bget?ko:K18655 O61305 1654 9.7e-183 DEAD-box helicase Dbp80 OS=Drosophila melanogaster GN=Dbp80 PE=1 SV=1 PF04851//PF00539//PF00270 Type III restriction enzyme, res subunit//Transactivating regulatory protein (Tat)//DEAD/DEAH box helicase GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003700//GO:0003677//GO:0016787//GO:0005524//GO:0008026 nucleic acid binding//transcription factor activity, sequence-specific DNA binding//DNA binding//hydrolase activity//ATP binding//ATP-dependent helicase activity GO:0042025//GO:0005667 host cell nucleus//transcription factor complex KOG0332 ATP-dependent RNA helicase Cluster-8309.38628 BF_2 556.48 15.54 1785 91079768 XP_966889.1 764 3.0e-78 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 392 1.7e-36 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF00106//PF01073//PF01370 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003824//GO:0050662//GO:0003854//GO:0000166 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//nucleotide binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.38629 BF_2 109.00 50.55 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38630 BF_2 1593.23 18.97 3800 642922280 XP_008193091.1 2505 8.3e-280 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.7e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- KOG3731 Sulfatases Cluster-8309.38634 BF_2 170.74 5.39 1612 646717218 KDR20164.1 788 4.4e-81 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 5.06098e-58 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 1.0e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00313//PF16367//PF00076 'Cold-shock' DNA-binding domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.38635 BF_2 1421.88 20.93 3129 91088017 XP_974079.1 1338 1.4e-144 PREDICTED: graves disease carrier protein [Tribolium castaneum]>gi|270011890|gb|EFA08338.1| hypothetical protein TcasGA2_TC005981 [Tribolium castaneum] -- -- -- -- -- K15084 SLC25A16, GDA, LEU5 solute carrier family 25 (mitochondrial carrier protein), member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15084 Q8C0K5 814 3.4e-85 Graves disease carrier protein homolog OS=Mus musculus GN=Slc25a16 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0005743//GO:0016021 mitochondrial inner membrane//integral component of membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.38636 BF_2 287.53 8.02 1786 91088017 XP_974079.1 780 4.2e-80 PREDICTED: graves disease carrier protein [Tribolium castaneum]>gi|270011890|gb|EFA08338.1| hypothetical protein TcasGA2_TC005981 [Tribolium castaneum] -- -- -- -- -- K15084 SLC25A16, GDA, LEU5 solute carrier family 25 (mitochondrial carrier protein), member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15084 Q8C0K5 450 3.2e-43 Graves disease carrier protein homolog OS=Mus musculus GN=Slc25a16 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.38637 BF_2 819.83 18.83 2108 531447909 AGT57849.1 701 7.1e-71 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 487 1.9e-47 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067//PF00328 Cytochrome P450//Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497//GO:0055114 riboflavin metabolic process//hexachlorocyclohexane metabolic process//oxidation-reduction process GO:0003993//GO:0016705//GO:0005506//GO:0020037 acid phosphatase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.38638 BF_2 44.58 1.15 1908 91091818 XP_966528.1 1242 1.2e-133 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 871 5.1e-92 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0006810//GO:0007268//GO:0007165//GO:0006811 transport//synaptic transmission//signal transduction//ion transport GO:0005234//GO:0004970//GO:0005215 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//transporter activity GO:0016020 membrane -- -- Cluster-8309.38639 BF_2 901.68 8.66 4645 91092690 XP_971771.1 1842 7.7e-203 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 5.09725e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 956 1.7e-101 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.38640 BF_2 117.65 0.85 6091 270014864 EFA11312.1 1414 4.3e-153 hypothetical protein TcasGA2_TC010850 [Tribolium castaneum] 826471828 XM_012680836.1 139 1.49113e-63 PREDICTED: Monomorium pharaonis myocyte-specific enhancer factor 2 (LOC105836654), transcript variant X5, mRNA K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 521 6.3e-51 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF00319//PF03554 SRF-type transcription factor (DNA-binding and dimerisation domain)//UL73 viral envelope glycoprotein -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.38642 BF_2 18.43 0.38 2342 332373574 AEE61928.1 817 2.8e-84 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4GAP7 488 1.6e-47 Facilitated trehalose transporter Tret1 OS=Drosophila persimilis GN=Tret1 PE=3 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.38645 BF_2 77.43 0.62 5473 91080669 XP_975087.1 970 1.2e-101 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 746866518 XM_011066023.1 149 3.6965e-69 PREDICTED: Acromyrmex echinatior vesicle-trafficking protein SEC22b (LOC105152004), transcript variant X3, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 719 6.2e-74 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.38646 BF_2 17.24 1.05 975 642933931 XP_008197572.1 535 5.8e-52 PREDICTED: nucleoplasmin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27415 214 4.0e-16 Nucleoplasmin-like protein OS=Drosophila melanogaster GN=Nlp PE=1 SV=1 PF02724//PF11081 CDC45-like protein//Protein of unknown function (DUF2890) GO:0016032//GO:0006270 viral process//DNA replication initiation -- -- -- -- -- -- Cluster-8309.38647 BF_2 798.45 9.86 3675 91078854 XP_971956.1 810 2.8e-83 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit C [Tribolium castaneum]>gi|270004131|gb|EFA00579.1| hypothetical protein TcasGA2_TC003449 [Tribolium castaneum] 242023017 XM_002431888.1 35 5.82994e-06 Pediculus humanus corporis Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative, mRNA K03859 PIGC, GPI2 phosphatidylinositol glycan, class C http://www.genome.jp/dbget-bin/www_bget?ko:K03859 Q92535 456 1.3e-43 Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Homo sapiens GN=PIGC PE=2 SV=1 PF01158//PF06432 Ribosomal protein L36e//Phosphatidylinositol N-acetylglucosaminyltransferase GO:0006412//GO:0006506//GO:0042254 translation//GPI anchor biosynthetic process//ribosome biogenesis GO:0017176//GO:0003735 phosphatidylinositol N-acetylglucosaminyltransferase activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-8309.38649 BF_2 587.57 6.60 4014 642923252 XP_008193678.1 4688 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 390178834 XM_001359343.3 125 5.93776e-56 Drosophila pseudoobscura pseudoobscura GA18295 (Dpse\GA18295), partial mRNA K01191 E3.2.1.24 alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01191 Q8BRK9 1596 9.2e-176 Alpha-mannosidase 2x OS=Mus musculus GN=Man2a2 PE=2 SV=2 PF09261//PF07748//PF01074 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0008270//GO:0004553//GO:0004559//GO:0015923 zinc ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.38650 BF_2 264.00 4.47 2757 440908077 ELR58138.1 1057 4.9e-112 Insulin enhancer protein ISL-1, partial [Bos mutus] 194758652 XM_001961540.1 171 1.09e-81 Drosophila ananassae GF14867 (Dana\GF14867), mRNA K09370 ISL1 insulin gene enhancer protein ISL-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09370 P50211 1050 1.3e-112 Insulin gene enhancer protein ISL-1 OS=Gallus gallus GN=ISL1 PE=2 SV=1 PF00046//PF12300//PF05920//PF06305//PF00412 Homeobox domain//Protein of unknown function (DUF3628)//Homeobox KN domain//Protein of unknown function (DUF1049)//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0016817//GO:0003677//GO:0008270 hydrolase activity, acting on acid anhydrides//DNA binding//zinc ion binding GO:0005887 integral component of plasma membrane KOG0490 Transcription factor, contains HOX domain Cluster-8309.38653 BF_2 247.08 0.52 20177 642937892 XP_008200345.1 16472 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 3.67229e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 9599 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF02207//PF04410//PF03875//PF02806//PF01667//PF03488 Putative zinc finger in N-recognin (UBR box)//Gar1/Naf1 RNA binding region//Statherin//Alpha amylase, C-terminal all-beta domain//Ribosomal protein S27//Nematode insulin-related peptide beta type GO:0006412//GO:0042742//GO:0030500//GO:0007165//GO:0005975//GO:0001522//GO:0042254 translation//defense response to bacterium//regulation of bone mineralization//signal transduction//carbohydrate metabolic process//pseudouridine synthesis//ribosome biogenesis GO:0005179//GO:0003824//GO:0043169//GO:0046848//GO:0003735//GO:0008270 hormone activity//catalytic activity//cation binding//hydroxyapatite binding//structural constituent of ribosome//zinc ion binding GO:0005576//GO:0005622//GO:0005840 extracellular region//intracellular//ribosome KOG1776 Zn-binding protein Push Cluster-8309.38654 BF_2 49.23 0.75 3041 122064577 P81926.2 336 2.2e-28 RecName: Full=Superoxide dismutase [Cu-Zn] [Halocynthia roretzi] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 336 8.9e-30 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.38656 BF_2 1674.64 10.12 7212 332375504 AEE62893.1 1136 8.8e-121 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 8.5e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF04111//PF16944//PF12474//PF01166//PF00997//PF02183//PF07850//PF15898 Autophagy protein Apg6//Fungal potassium channel//Polo kinase kinase//TSC-22/dip/bun family//Kappa casein//Homeobox associated leucine zipper//Renin receptor-like protein//cGMP-dependent protein kinase interacting domain GO:0009069//GO:0006914//GO:0007165//GO:0006355//GO:0016310//GO:0071805//GO:0006813 serine family amino acid metabolic process//autophagy//signal transduction//regulation of transcription, DNA-templated//phosphorylation//potassium ion transmembrane transport//potassium ion transport GO:0015079//GO:0004674//GO:0003700//GO:0019901//GO:0043565//GO:0004872 potassium ion transmembrane transporter activity//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//protein kinase binding//sequence-specific DNA binding//receptor activity GO:0005887//GO:0016021//GO:0005667//GO:0005576 integral component of plasma membrane//integral component of membrane//transcription factor complex//extracellular region KOG4001 Axonemal dynein light chain Cluster-8309.38657 BF_2 609.13 2.42 10813 270001100 EEZ97547.1 2545 5.5e-284 hypothetical protein TcasGA2_TC011397 [Tribolium castaneum] 170032990 XM_001844311.1 225 4.13604e-111 Culex quinquefasciatus leucine-rich repeat protein SHOC-2, mRNA K19613 SHOC2, SUR8 leucine-rich repeat protein SHOC2 http://www.genome.jp/dbget-bin/www_bget?ko:K19613 B0W6M9 1953 1.0e-216 Leucine-rich repeat protein soc-2 homolog OS=Culex quinquefasciatus GN=Sur-8 PE=3 SV=1 PF13855//PF14304//PF00595//PF01378//PF13180//PF00412//PF10468//PF00560 Leucine rich repeat//Transcription termination and cleavage factor C-terminal//PDZ domain (Also known as DHR or GLGF)//B domain//PDZ domain//LIM domain//Carboxypeptidase inhibitor I68//Leucine Rich Repeat GO:0010951//GO:0031124//GO:0007596 negative regulation of endopeptidase activity//mRNA 3'-end processing//blood coagulation GO:0008270//GO:0008191//GO:0005515 zinc ion binding//metalloendopeptidase inhibitor activity//protein binding GO:0005618 cell wall KOG0619 FOG: Leucine rich repeat Cluster-8309.38658 BF_2 225.35 3.44 3030 820805524 AKG92753.1 937 4.4e-98 mnt1 [Leptinotarsa decemlineata] -- -- -- -- -- K09115 MNT, ROX MAX-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09115 Q0VH32 363 6.6e-33 Max-binding protein MNT OS=Xenopus laevis GN=mnt PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.38659 BF_2 2432.00 42.57 2677 91088885 XP_972389.1 2029 9.2e-225 PREDICTED: 26S protease regulatory subunit 7 [Tribolium castaneum]>gi|270012350|gb|EFA08798.1| hypothetical protein TcasGA2_TC006492 [Tribolium castaneum] 768445130 XM_011566149.1 416 0 PREDICTED: Plutella xylostella 26S protease regulatory subunit 7 (LOC105394268), mRNA K03061 PSMC2, RPT1 26S proteasome regulatory subunit T1 http://www.genome.jp/dbget-bin/www_bget?ko:K03061 P46472 1907 5.3e-212 26S protease regulatory subunit 7 OS=Xenopus laevis GN=psmc2 PE=2 SV=1 PF07724//PF00004//PF00158//PF07823//PF06068//PF05496//PF07728//PF14532//PF01695//PF00910//PF07726 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//Cyclic phosphodiesterase-like protein//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//RNA helicase//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0030163//GO:0006355//GO:0006281 DNA recombination//protein catabolic process//regulation of transcription, DNA-templated//DNA repair GO:0009378//GO:0017111//GO:0003724//GO:0003678//GO:0003723//GO:0016887//GO:0004112//GO:0005524//GO:0008134 four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity//DNA helicase activity//RNA binding//ATPase activity//cyclic-nucleotide phosphodiesterase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0005737//GO:0009379 replication fork//transcription factor complex//cytoplasm//Holliday junction helicase complex KOG0729 26S proteasome regulatory complex, ATPase RPT1 Cluster-8309.38660 BF_2 12014.53 171.48 3218 478253025 ENN73405.1 1585 3.4e-173 hypothetical protein YQE_09967, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q15075 179 1.5e-11 Early endosome antigen 1 OS=Homo sapiens GN=EEA1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38661 BF_2 85.46 1.44 2768 642937304 XP_008198778.1 946 3.6e-99 PREDICTED: zinc finger SWIM domain-containing protein 8 [Tribolium castaneum] 194892748 XM_001977686.1 132 5.23793e-60 Drosophila erecta GG19197 (Dere\GG19197), mRNA -- -- -- -- A7E305 416 4.3e-39 Zinc finger SWIM domain-containing protein 8 OS=Bos taurus GN=ZSWIM8 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38662 BF_2 7002.13 69.76 4486 91077984 XP_968658.1 1421 4.9e-154 PREDICTED: serine protease 42 [Tribolium castaneum]>gi|270002734|gb|EEZ99181.1| serine protease H2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 440 1.1e-41 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF09284//PF00089 Rhamnogalacturonan lyase B, N-terminal//Trypsin GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0016837//GO:0030246//GO:0008233//GO:0004252 carbon-oxygen lyase activity, acting on polysaccharides//carbohydrate binding//peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.38663 BF_2 417.43 11.27 1836 728416984 AIY68330.1 1605 9.3e-176 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 775 6.7e-81 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.38664 BF_2 204.32 8.58 1283 91086607 XP_973974.1 276 8.3e-22 PREDICTED: V-type proton ATPase subunit G [Tribolium castaneum]>gi|270009777|gb|EFA06225.1| hypothetical protein TcasGA2_TC009074 [Tribolium castaneum] -- -- -- -- -- K02152 ATPeV1G, ATP6G V-type H+-transporting ATPase subunit G http://www.genome.jp/dbget-bin/www_bget?ko:K02152 Q25532 245 1.3e-19 V-type proton ATPase subunit G OS=Manduca sexta PE=3 SV=1 PF04857//PF14942//PF07464//PF03938//PF07851//PF04111 CAF1 family ribonuclease//Organelle biogenesis, Muted-like protein//Apolipophorin-III precursor (apoLp-III)//Outer membrane protein (OmpH-like)//TMPIT-like protein//Autophagy protein Apg6 GO:0006869//GO:0006914 lipid transport//autophagy GO:0008289//GO:0051082 lipid binding//unfolded protein binding GO:0005634//GO:0016021//GO:0031083//GO:0030133//GO:0005576 nucleus//integral component of membrane//BLOC-1 complex//transport vesicle//extracellular region KOG1772 Vacuolar H+-ATPase V1 sector, subunit G Cluster-8309.38665 BF_2 98.90 1.94 2424 642929061 XP_008195675.1 898 1.2e-93 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205 WH2 motif -- -- GO:0003779 actin binding -- -- -- -- Cluster-8309.38666 BF_2 266.08 2.55 4651 546680383 ERL90662.1 183 1.8e-10 hypothetical protein D910_08009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07517//PF02179//PF00816//PF04905//PF07544 SecA DEAD-like domain//BAG domain//H-NS histone family//NAB conserved region 2 (NCD2)//RNA polymerase II transcription mediator complex subunit 9 GO:0006355//GO:0045892//GO:0006357//GO:0017038 regulation of transcription, DNA-templated//negative regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//protein import GO:0051087//GO:0003677//GO:0001104//GO:0005524 chaperone binding//DNA binding//RNA polymerase II transcription cofactor activity//ATP binding GO:0016020//GO:0005622//GO:0016592//GO:0005634 membrane//intracellular//mediator complex//nucleus -- -- Cluster-8309.38668 BF_2 1997.83 14.88 5903 642919151 XP_008191758.1 3900 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 821465109 XM_003759914.2 38 2.02026e-07 PREDICTED: Sarcophilus harrisii complement component 6 (C6), mRNA -- -- -- -- Q98930 2175 9.8e-243 Sortilin-related receptor (Fragment) OS=Gallus gallus GN=SORL1 PE=2 SV=1 PF04345//PF11057//PF00041//PF00057 Chorismate lyase//Cortexin of kidney//Fibronectin type III domain//Low-density lipoprotein receptor domain class A GO:0006744 ubiquinone biosynthetic process GO:0008813//GO:0005515 chorismate lyase activity//protein binding GO:0031224//GO:0005737 intrinsic component of membrane//cytoplasm KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38669 BF_2 766.03 12.11 2933 642919151 XP_008191758.1 2747 5.6e-308 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88307 1587 7.4e-175 Sortilin-related receptor OS=Mus musculus GN=Sorl1 PE=1 SV=3 PF00057//PF02077//PF03216//PF11057 Low-density lipoprotein receptor domain class A//SURF4 family//Rhabdovirus nucleoprotein//Cortexin of kidney -- -- GO:0005515 protein binding GO:0016021//GO:0031224//GO:0019013 integral component of membrane//intrinsic component of membrane//viral nucleocapsid KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38670 BF_2 211.40 1.54 6024 642919151 XP_008191758.1 3785 0.0e+00 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] 821465109 XM_003759914.2 38 2.06192e-07 PREDICTED: Sarcophilus harrisii complement component 6 (C6), mRNA -- -- -- -- Q98930 2118 4.1e-236 Sortilin-related receptor (Fragment) OS=Gallus gallus GN=SORL1 PE=2 SV=1 PF00057//PF11057//PF00041//PF04345 Low-density lipoprotein receptor domain class A//Cortexin of kidney//Fibronectin type III domain//Chorismate lyase GO:0006744 ubiquinone biosynthetic process GO:0005515//GO:0008813 protein binding//chorismate lyase activity GO:0031224//GO:0005737 intrinsic component of membrane//cytoplasm KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.38671 BF_2 4.00 1.45 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38672 BF_2 896.55 13.51 3063 270002486 EEZ98933.1 2974 0.0e+00 hypothetical protein TcasGA2_TC004554 [Tribolium castaneum] 749758627 XM_011142875.1 118 3.51762e-52 PREDICTED: Harpegnathos saltator furin-like protease 2 (LOC105184226), transcript variant X4, mRNA -- -- -- -- P30432 1724 1.0e-190 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF01483//PF00757 Proprotein convertase P-domain//Furin-like cysteine rich region GO:0007169//GO:0006468//GO:0006508 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation//proteolysis GO:0004714//GO:0004252//GO:0005524 transmembrane receptor protein tyrosine kinase activity//serine-type endopeptidase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.38673 BF_2 5912.57 19.44 13009 91092056 XP_970271.1 4135 0.0e+00 PREDICTED: dihydropyrimidine dehydrogenase [NADP(+)] isoform X2 [Tribolium castaneum]>gi|270004691|gb|EFA01139.1| hypothetical protein TcasGA2_TC010364 [Tribolium castaneum] 157125487 XM_001654304.1 70 7.26373e-25 Aedes aegypti AAEL010204-RA partial mRNA K00207 DPYD dihydropyrimidine dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00207 Q6NYG8 3356 0.0e+00 Dihydropyrimidine dehydrogenase [NADP(+)] OS=Danio rerio GN=dpyd PE=2 SV=1 PF01593//PF01207//PF06574//PF01884//PF01704//PF04218//PF07992//PF00196//PF00070//PF02796//PF05946//PF05225//PF04545//PF03184//PF01180 Flavin containing amine oxidoreductase//Dihydrouridine synthase (Dus)//FAD synthetase//PcrB family//UTP--glucose-1-phosphate uridylyltransferase//CENP-B N-terminal DNA-binding domain//Pyridine nucleotide-disulphide oxidoreductase//Bacterial regulatory proteins, luxR family//Pyridine nucleotide-disulphide oxidoreductase//Helix-turn-helix domain of resolvase//Toxin-coregulated pilus subunit TcpA//helix-turn-helix, Psq domain//Sigma-70, region 4//DDE superfamily endonuclease//Dihydroorotate dehydrogenase GO:0009231//GO:0008152//GO:0006310//GO:0006771//GO:0055114//GO:0006118//GO:0006222//GO:0006352//GO:0006206//GO:0006207//GO:0009405//GO:0008033//GO:0006355 riboflavin biosynthetic process//metabolic process//DNA recombination//riboflavin metabolic process//oxidation-reduction process//obsolete electron transport//UMP biosynthetic process//DNA-templated transcription, initiation//pyrimidine nucleobase metabolic process//'de novo' pyrimidine nucleobase biosynthetic process//pathogenesis//tRNA processing//regulation of transcription, DNA-templated GO:0016491//GO:0016987//GO:0003676//GO:0070569//GO:0003700//GO:0016765//GO:0017150//GO:0004158//GO:0003677//GO:0009055//GO:0050660//GO:0000150//GO:0016627//GO:0003919//GO:0051536 oxidoreductase activity//sigma factor activity//nucleic acid binding//uridylyltransferase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring alkyl or aryl (other than methyl) groups//tRNA dihydrouridine synthase activity//dihydroorotate oxidase activity//DNA binding//electron carrier activity//flavin adenine dinucleotide binding//recombinase activity//oxidoreductase activity, acting on the CH-CH group of donors//FMN adenylyltransferase activity//iron-sulfur cluster binding GO:0005667//GO:0043230//GO:0009289//GO:0005737 transcription factor complex//extracellular organelle//pilus//cytoplasm KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.38674 BF_2 31.99 0.36 3973 642928439 XP_008193785.1 571 1.6e-55 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 542212872 XM_003439847.2 103 9.97368e-44 PREDICTED: Oreochromis niloticus ras-related protein Rab-8A-like (LOC100691063), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P35280 516 1.6e-50 Ras-related protein Rab-8A OS=Rattus norvegicus GN=Rab8a PE=1 SV=2 PF10662//PF00071//PF00025//PF08477//PF07728 Ethanolamine utilisation - propanediol utilisation//Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily) GO:0006576//GO:0007264//GO:0015031 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport GO:0005525//GO:0005524//GO:0016887 GTP binding//ATP binding//ATPase activity -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.38676 BF_2 350.73 6.59 2512 642928849 XP_008195587.1 445 4.1e-41 PREDICTED: mediator of RNA polymerase II transcription subunit 16 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15159 MED16 mediator of RNA polymerase II transcription subunit 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15159 Q16K67 223 9.3e-17 Mediator of RNA polymerase II transcription subunit 16 OS=Aedes aegypti GN=MED16 PE=3 SV=1 PF08395//PF02532 7tm Chemosensory receptor//Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979//GO:0050909 photosynthesis//sensory perception of taste -- -- GO:0009539//GO:0009523//GO:0016021//GO:0016020 photosystem II reaction center//photosystem II//integral component of membrane//membrane -- -- Cluster-8309.38677 BF_2 96.00 4.44 1192 642914847 XP_008195031.1 328 7.1e-28 PREDICTED: transmembrane protein 60 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K174 129 3.5e-06 Transmembrane protein 60 OS=Mus musculus GN=Tmem60 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38681 BF_2 25.35 0.64 1947 91076170 XP_971503.1 1431 1.5e-155 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 195 3.48977e-95 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 289 1.6e-24 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38683 BF_2 1735.58 31.57 2587 478260541 ENN80244.1 467 1.2e-43 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911792 XM_008202523.1 93 2.34248e-38 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X2, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q12974 310 7.8e-27 Protein tyrosine phosphatase type IVA 2 OS=Homo sapiens GN=PTP4A2 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.38684 BF_2 1416.90 35.88 1939 91081621 XP_966892.1 1748 2.6e-192 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ETN3 866 2.0e-91 Probable 4-coumarate--CoA ligase 3 OS=Oryza sativa subsp. japonica GN=4CL3 PE=2 SV=1 PF03144//PF00501 Elongation factor Tu domain 2//AMP-binding enzyme GO:0008152 metabolic process GO:0003824//GO:0005525 catalytic activity//GTP binding -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.38686 BF_2 341.04 8.51 1963 91078084 XP_972157.1 1933 9.2e-214 PREDICTED: protein neuralized isoform X1 [Tribolium castaneum]>gi|270001399|gb|EEZ97846.1| hypothetical protein TcasGA2_TC000216 [Tribolium castaneum] -- -- -- -- -- K01931 NEUR protein neuralized http://www.genome.jp/dbget-bin/www_bget?ko:K01931 Q24746 602 8.2e-61 Protein neuralized OS=Drosophila virilis GN=neur PE=3 SV=1 -- -- -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.38689 BF_2 8719.61 22.01 16861 270010741 EFA07189.1 6019 0.0e+00 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] 407731599 JQ771517.1 1610 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF08686//PF04545//PF05986//PF00014//PF13895//PF02714 E1-E2 ATPase//PLAC (protease and lacunin) domain//Sigma-70, region 4//ADAM-TS Spacer 1//Kunitz/Bovine pancreatic trypsin inhibitor domain//Immunoglobulin domain//Calcium-dependent channel, 7TM region, putative phosphate GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0000166//GO:0016987//GO:0003700//GO:0008233//GO:0046872//GO:0004222//GO:0003677//GO:0004867//GO:0005515 nucleotide binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//peptidase activity//metal ion binding//metalloendopeptidase activity//DNA binding//serine-type endopeptidase inhibitor activity//protein binding GO:0016020//GO:0031012//GO:0005667 membrane//extracellular matrix//transcription factor complex KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.38690 BF_2 99.05 2.00 2364 642930472 XP_008196416.1 262 6.4e-20 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] 407731617 JQ771526.1 224 3.21712e-111 Tetraopes tetrophthalmus Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds -- -- -- -- Q868Z9 159 2.3e-09 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF08686 PLAC (protease and lacunin) domain -- -- GO:0008233 peptidase activity -- -- -- -- Cluster-8309.38691 BF_2 31.00 2.02 928 662195082 XP_008470516.1 159 2.2e-08 PREDICTED: sodium/potassium-transporting ATPase subunit alpha-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q9YH26 149 1.3e-08 Sodium/potassium-transporting ATPase subunit alpha-1 OS=Oreochromis mossambicus GN=atp1a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.38692 BF_2 620.50 1.54 17152 270010741 EFA07189.1 4810 0.0e+00 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] 407731599 JQ771517.1 1610 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF05986//PF13895//PF00122//PF08686//PF02480//PF00014//PF02714//PF04545 ADAM-TS Spacer 1//Immunoglobulin domain//E1-E2 ATPase//PLAC (protease and lacunin) domain//Alphaherpesvirus glycoprotein E//Kunitz/Bovine pancreatic trypsin inhibitor domain//Calcium-dependent channel, 7TM region, putative phosphate//Sigma-70, region 4 GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003700//GO:0008233//GO:0046872//GO:0000166//GO:0016987//GO:0004867//GO:0005515//GO:0004222//GO:0003677 transcription factor activity, sequence-specific DNA binding//peptidase activity//metal ion binding//nucleotide binding//sigma factor activity//serine-type endopeptidase inhibitor activity//protein binding//metalloendopeptidase activity//DNA binding GO:0016020//GO:0005667//GO:0031012 membrane//transcription factor complex//extracellular matrix KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.38693 BF_2 2261.36 5.77 16690 826459797 XP_012533974.1 4761 0.0e+00 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X3 [Monomorium pharaonis] 407731599 JQ771517.1 1610 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF02714//PF13895//PF00014//PF05986//PF04545//PF08686//PF00122 Calcium-dependent channel, 7TM region, putative phosphate//Immunoglobulin domain//Kunitz/Bovine pancreatic trypsin inhibitor domain//ADAM-TS Spacer 1//Sigma-70, region 4//PLAC (protease and lacunin) domain//E1-E2 ATPase GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0000166//GO:0016987//GO:0008233//GO:0003700//GO:0046872//GO:0004222//GO:0003677//GO:0004867//GO:0005515 nucleotide binding//sigma factor activity//peptidase activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//metalloendopeptidase activity//DNA binding//serine-type endopeptidase inhibitor activity//protein binding GO:0016020//GO:0031012//GO:0005667 membrane//extracellular matrix//transcription factor complex KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.38698 BF_2 2179.84 31.12 3217 642916840 XP_008199525.1 1090 8.5e-116 PREDICTED: serine/threonine-protein phosphatase 2B catalytic subunit 2-like isoform X3 [Tribolium castaneum] 170068311 XM_001868784.1 204 5.76319e-100 Culex quinquefasciatus serine/threonine-protein phosphatase 2B catalytic subunit 2, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q9VXF1 933 5.6e-99 Serine/threonine-protein phosphatase 2B catalytic subunit 3 OS=Drosophila melanogaster GN=CanA-14F PE=1 SV=4 -- -- -- -- -- -- -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.38699 BF_2 7389.36 16.82 18665 612342210 AHW99830.1 19187 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1380 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 16225 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF13499//PF13833//PF02815//PF00622//PF01365//PF00487//PF06423//PF06459//PF00520 EF-hand domain pair//EF-hand domain pair//MIR domain//SPRY domain//RIH domain//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//Ion transport protein GO:0006506//GO:0006811//GO:0006629//GO:0006874//GO:0006816//GO:0055085//GO:0070588 GPI anchor biosynthetic process//ion transport//lipid metabolic process//cellular calcium ion homeostasis//calcium ion transport//transmembrane transport//calcium ion transmembrane transport GO:0005509//GO:0005262//GO:0005219//GO:0005515//GO:0016746//GO:0005216 calcium ion binding//calcium channel activity//ryanodine-sensitive calcium-release channel activity//protein binding//transferase activity, transferring acyl groups//ion channel activity GO:0016020//GO:0005789//GO:0005622//GO:0016021 membrane//endoplasmic reticulum membrane//intracellular//integral component of membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.38700 BF_2 857.97 14.09 2834 270004742 EFA01190.1 2041 4.0e-226 hypothetical protein TcasGA2_TC010516 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 1586 9.4e-175 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006090//GO:0071436//GO:0006814//GO:0006525//GO:0006560 pyruvate metabolic process//sodium ion export//sodium ion transport//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane KOG3097 Predicted membrane protein Cluster-8309.38701 BF_2 333.67 2.57 5710 642922300 XP_008193101.1 1696 8.1e-186 PREDICTED: LOW QUALITY PROTEIN: isovaleryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1323 5.9e-144 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF02770//PF02270//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Transcription initiation factor IIF, beta subunit//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114//GO:0006367//GO:0006118//GO:0006366//GO:0008152 oxidation-reduction process//transcription initiation from RNA polymerase II promoter//obsolete electron transport//transcription from RNA polymerase II promoter//metabolic process GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.38702 BF_2 536.10 2.23 10360 91088831 XP_970461.1 3072 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 5 isoform X1 [Tribolium castaneum]>gi|270012333|gb|EFA08781.1| hypothetical protein TcasGA2_TC006471 [Tribolium castaneum] 645001221 XM_001601899.3 112 2.5959e-48 PREDICTED: Nasonia vitripennis 60S ribosomal protein L34-like (LOC100113629), mRNA K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O88813 1719 1.3e-189 Long-chain-fatty-acid--CoA ligase 5 OS=Rattus norvegicus GN=Acsl5 PE=1 SV=1 PF01434//PF02601//PF16053//PF01363//PF07168//PF05008//PF00501//PF01199 Peptidase family M41//Exonuclease VII, large subunit//Mitochondrial 28S ribosomal protein S34//FYVE zinc finger//Ureide permease//Vesicle transport v-SNARE protein N-terminus//AMP-binding enzyme//Ribosomal protein L34e GO:0006886//GO:0042254//GO:0006412//GO:0071705//GO:0008152//GO:0006308//GO:0006508 intracellular protein transport//ribosome biogenesis//translation//nitrogen compound transport//metabolic process//DNA catabolic process//proteolysis GO:0005524//GO:0004222//GO:0003735//GO:0008855//GO:0003824//GO:0046872 ATP binding//metalloendopeptidase activity//structural constituent of ribosome//exodeoxyribonuclease VII activity//catalytic activity//metal ion binding GO:0005739//GO:0005622//GO:0009318//GO:0005840//GO:0016020 mitochondrion//intracellular//exodeoxyribonuclease VII complex//ribosome//membrane KOG1256 Long-chain acyl-CoA synthetases (AMP-forming) Cluster-8309.38703 BF_2 1414.00 8.01 7676 270009277 EFA05725.1 471 1.2e-43 homolog of RecQ [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O96923 154 2.9e-08 Gelsolin-related protein of 125 kDa OS=Dictyostelium discoideum GN=gnrA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38704 BF_2 479.18 10.41 2212 642933080 XP_008197251.1 1014 3.8e-107 PREDICTED: ribosome biogenesis regulatory protein homolog [Tribolium castaneum] 795027340 XM_012006858.1 35 3.4888e-06 PREDICTED: Vollenhovia emeryi ribosome biogenesis regulatory protein homolog (LOC105558919), mRNA K14852 RRS1 regulator of ribosome biosynthesis http://www.genome.jp/dbget-bin/www_bget?ko:K14852 Q2KIH4 604 5.4e-61 Ribosome biogenesis regulatory protein homolog OS=Bos taurus GN=RRS1 PE=2 SV=1 PF04939 Ribosome biogenesis regulatory protein (RRS1) GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1765 Regulator of ribosome synthesis Cluster-8309.38707 BF_2 458.35 4.40 4641 357625687 EHJ76049.1 1321 2.0e-142 dimethyladenosine transferase [Danaus plexippus] 505801989 XM_004608470.1 131 3.17545e-59 PREDICTED: Sorex araneus DIM1 dimethyladenosine transferase 1 homolog (S. cerevisiae) (DIMT1), mRNA K14191 DIM1 18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14191 Q9VAQ5 1179 2.4e-127 Probable dimethyladenosine transferase OS=Drosophila melanogaster GN=CG11837 PE=2 SV=1 PF05401//PF01209//PF05958//PF09445//PF08123//PF01135//PF05175//PF16711//PF02390//PF08241 Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family//tRNA (Uracil-5-)-methyltransferase//RNA cap guanine-N2 methyltransferase//Histone methylation protein DOT1//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Actin-binding domain of plant-specific actin-binding protein//Putative methyltransferase//Methyltransferase domain GO:0009452//GO:0008152//GO:0001510//GO:0006400//GO:0046500//GO:0009877//GO:0009451//GO:0006479//GO:0006464//GO:0009312//GO:0006554//GO:0006396//GO:0008033 7-methylguanosine RNA capping//metabolic process//RNA methylation//tRNA modification//S-adenosylmethionine metabolic process//nodulation//RNA modification//protein methylation//cellular protein modification process//oligosaccharide biosynthetic process//lysine catabolic process//RNA processing//tRNA processing GO:0008173//GO:0008757//GO:0018024//GO:0004719//GO:0008176//GO:0003779//GO:0008168 RNA methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//histone-lysine N-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//actin binding//methyltransferase activity -- -- KOG0820 Ribosomal RNA adenine dimethylase Cluster-8309.38709 BF_2 2810.76 47.84 2745 91078042 XP_966587.1 679 3.3e-68 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 419 1.9e-39 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38710 BF_2 4.22 0.32 831 270002313 EEZ98760.1 331 2.2e-28 hypothetical protein TcasGA2_TC001324 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 247 5.1e-20 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 PF01791 DeoC/LacD family aldolase -- -- GO:0016829 lyase activity -- -- -- -- Cluster-8309.38711 BF_2 62.74 1.20 2476 642916856 XP_968783.3 169 4.1e-09 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38712 BF_2 2932.76 21.06 6113 642916856 XP_968783.3 1187 9.1e-127 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] 242023932 XM_002432340.1 66 5.69595e-23 Pediculus humanus corporis proteasome subunit beta type, putative, mRNA K02732 PSMB1 20S proteasome subunit beta 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02732 P40304 767 1.9e-79 Proteasome subunit beta type-1 OS=Drosophila melanogaster GN=Prosbeta6 PE=2 SV=2 PF00227//PF13673//PF00096//PF13413//PF12844//PF01381//PF04988//PF13912 Proteasome subunit//Acetyltransferase (GNAT) domain//Zinc finger, C2H2 type//Helix-turn-helix domain//Helix-turn-helix domain//Helix-turn-helix//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger GO:0051603//GO:0042967 proteolysis involved in cellular protein catabolic process//acyl-carrier-protein biosynthetic process GO:0043565//GO:0004298//GO:0046872//GO:0003677//GO:0008080 sequence-specific DNA binding//threonine-type endopeptidase activity//metal ion binding//DNA binding//N-acetyltransferase activity GO:0005839//GO:0005634 proteasome core complex//nucleus KOG0179 20S proteasome, regulatory subunit beta type PSMB1/PRE7 Cluster-8309.38713 BF_2 1473.10 531.20 402 546676039 ERL87122.1 159 9.5e-09 hypothetical protein D910_04522 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38714 BF_2 162.82 1.29 5570 478252696 ENN73092.1 1663 5.3e-182 hypothetical protein YQE_10296, partial [Dendroctonus ponderosae] -- -- -- -- -- K04681 RBL1 retinoblastoma-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04681 Q64701 1034 1.9e-110 Retinoblastoma-like protein 1 OS=Mus musculus GN=Rbl1 PE=1 SV=3 PF01858//PF01857 Retinoblastoma-associated protein A domain//Retinoblastoma-associated protein B domain GO:0051726 regulation of cell cycle -- -- GO:0005634 nucleus KOG1010 Rb (Retinoblastoma tumor suppressor)-related protein Cluster-8309.38716 BF_2 61.00 1.47 2022 557781264 XP_005190251.1 148 9.0e-07 PREDICTED: uncharacterized protein LOC101898742, partial [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.38717 BF_2 1111.47 52.49 1173 91090842 XP_972243.1 1533 1.3e-167 PREDICTED: large neutral amino acids transporter small subunit 1 [Tribolium castaneum]>gi|270013246|gb|EFA09694.1| hypothetical protein TcasGA2_TC011826 [Tribolium castaneum] 642935933 XM_967150.2 392 0 PREDICTED: Tribolium castaneum large neutral amino acids transporter small subunit 1 (LOC660956), mRNA K03450 SLC7A solute carrier family 7 (L-type amino acid transporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K03450 Q8BGK6 951 1.7e-101 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006810//GO:0006865//GO:0003333//GO:0055085 transport//amino acid transport//amino acid transmembrane transport//transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1287 Amino acid transporters Cluster-8309.38718 BF_2 107.76 1.71 2924 264667363 ACY71267.1 534 2.3e-51 ribosomal protein S24 [Chrysomela tremula] 642917806 XM_962484.3 213 5.19546e-105 PREDICTED: Tribolium castaneum 40S ribosomal protein S24 (LOC655928), mRNA K02974 RP-S24e, RPS24 small subunit ribosomal protein S24e http://www.genome.jp/dbget-bin/www_bget?ko:K02974 Q962Q6 511 4.4e-50 40S ribosomal protein S24 OS=Spodoptera frugiperda GN=RpS24 PE=2 SV=1 PF01282 Ribosomal protein S24e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3424 40S ribosomal protein S24 Cluster-8309.38720 BF_2 8362.08 101.75 3725 642928117 XP_008200164.1 422 2.8e-38 PREDICTED: protein anoxia up-regulated isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38721 BF_2 24460.50 335.73 3335 727098932 AIY54299.1 1395 3.8e-151 glyceraldehyde 3-phosphate dehydrogenase [Colaphellus bowringi] 195457061 XM_002075373.1 330 5.41337e-170 Drosophila willistoni GK17768 (Dwil\GK17768), mRNA K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q4U3L0 1314 3.8e-143 Glyceraldehyde-3-phosphate dehydrogenase OS=Glossina morsitans morsitans GN=Gapdh PE=2 SV=1 PF02800//PF00107//PF02826//PF00044 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0016620//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.38722 BF_2 203.07 4.08 2368 642923825 XP_008193895.1 1869 2.9e-206 PREDICTED: pseudouridine-metabolizing bifunctional protein C1861.05 [Tribolium castaneum] -- -- -- -- -- K16330 K16330 pseudouridine-5'-phosphate glycosidase / pseudouridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K16330 A7GCK7 778 3.9e-81 Pseudouridine-5'-phosphate glycosidase OS=Clostridium botulinum (strain Langeland / NCTC 10281 / Type F) GN=psuG PE=3 SV=1 PF05275//PF04227 Copper resistance protein B precursor (CopB)//Indigoidine synthase A like protein GO:0006878 cellular copper ion homeostasis GO:0016798//GO:0005507 hydrolase activity, acting on glycosyl bonds//copper ion binding GO:0009279 cell outer membrane KOG3009 Predicted carbohydrate kinase, contains PfkB domain Cluster-8309.38723 BF_2 3366.73 107.69 1595 270013857 EFA10305.1 878 1.6e-91 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83632 412 7.2e-39 27 kDa hemolymph protein OS=Galleria mellonella PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38724 BF_2 151.22 7.20 1166 642922790 XP_008193326.1 891 3.6e-93 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P19823 340 1.2e-30 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Homo sapiens GN=ITIH2 PE=1 SV=2 PF04227 Indigoidine synthase A like protein -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds -- -- -- -- Cluster-8309.38727 BF_2 94.70 1.12 3810 478263044 ENN81444.1 2150 1.2e-238 hypothetical protein YQE_02137, partial [Dendroctonus ponderosae] -- -- -- -- -- K10902 RECQL5 ATP-dependent DNA helicase Q5 http://www.genome.jp/dbget-bin/www_bget?ko:K10902 Q8VID5 1002 6.6e-107 ATP-dependent DNA helicase Q5 OS=Mus musculus GN=Recql5 PE=2 SV=1 PF08236//PF00391//PF00270 SRI (Set2 Rpb1 interacting) domain//PEP-utilising enzyme, mobile domain//DEAD/DEAH box helicase GO:0034968//GO:0016310//GO:0006554//GO:0006355//GO:0006479 histone lysine methylation//phosphorylation//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005524//GO:0018024//GO:0016772//GO:0003676 ATP binding//histone-lysine N-methyltransferase activity//transferase activity, transferring phosphorus-containing groups//nucleic acid binding GO:0005694 chromosome KOG0351 ATP-dependent DNA helicase Cluster-8309.38729 BF_2 693.73 10.44 3068 642920248 XP_008192267.1 1434 1.0e-155 PREDICTED: probable cytochrome P450 6a14 [Tribolium castaneum]>gi|270006371|gb|EFA02819.1| cytochrome P450 6BQ5 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 994 4.5e-106 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF03776//PF00893//PF00067 Septum formation topological specificity factor MinE//Small Multidrug Resistance protein//Cytochrome P450 GO:0051301//GO:0055114//GO:0032955 cell division//oxidation-reduction process//regulation of barrier septum assembly GO:0016705//GO:0016491//GO:0005488//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//binding//heme binding//iron ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.3873 BF_2 2.96 0.39 604 642916527 XP_008191079.1 451 2.0e-42 PREDICTED: glutamate receptor ionotropic, kainate 2-like [Tribolium castaneum] -- -- -- -- -- K05205 GRIK5 glutamate receptor, ionotropic kainate 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05205 Q61626 167 7.0e-11 Glutamate receptor ionotropic, kainate 5 OS=Mus musculus GN=Grik5 PE=2 SV=2 PF01155 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.38730 BF_2 244.91 5.28 2228 189240952 XP_971597.2 1948 1.9e-215 PREDICTED: methionine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q9VFL5 1426 2.6e-156 Methionine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-met PE=2 SV=2 PF09334//PF00133//PF08264 tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity -- -- KOG0436 Methionyl-tRNA synthetase Cluster-8309.38731 BF_2 125.00 8.87 877 189234232 XP_973217.2 444 1.9e-41 PREDICTED: serine/threonine-protein kinase Warts [Tribolium castaneum]>gi|270002603|gb|EEZ99050.1| hypothetical protein TcasGA2_TC004924 [Tribolium castaneum] 642912553 XM_968124.3 117 3.5256e-52 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Warts (LOC661996), mRNA K08791 LATS1_2, Wts serine/threonine-protein kinase LATS1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08791 -- -- -- -- -- -- -- -- GO:0016301 kinase activity -- -- -- -- Cluster-8309.38732 BF_2 24.92 0.47 2494 546685044 ERL94598.1 2180 2.7e-242 hypothetical protein D910_11875 [Dendroctonus ponderosae] 194765020 XM_001964590.1 263 7.09701e-133 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1543 8.0e-170 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF01420//PF06883//PF03949//PF00390 Type I restriction modification DNA specificity domain//RNA polymerase I, Rpa2 specific domain//Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain GO:0006351//GO:0006144//GO:0015976//GO:0006099//GO:0006206//GO:0006090//GO:0006304//GO:0006108//GO:0055114 transcription, DNA-templated//purine nucleobase metabolic process//carbon utilization//tricarboxylic acid cycle//pyrimidine nucleobase metabolic process//pyruvate metabolic process//DNA modification//malate metabolic process//oxidation-reduction process GO:0003899//GO:0003677//GO:0051287//GO:0004471 DNA-directed RNA polymerase activity//DNA binding//NAD binding//malate dehydrogenase (decarboxylating) (NAD+) activity GO:0005634//GO:0005730 nucleus//nucleolus KOG1257 NADP+-dependent malic enzyme Cluster-8309.38733 BF_2 983.82 7.09 6093 189240296 XP_973610.2 1369 7.1e-148 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 Q9R229 430 2.2e-40 Bone morphogenetic protein 10 OS=Mus musculus GN=Bmp10 PE=2 SV=2 PF00019//PF09172//PF01347 Transforming growth factor beta like domain//Domain of unknown function (DUF1943)//Lipoprotein amino terminal region GO:0006869//GO:0008283//GO:0007165//GO:0040007 lipid transport//cell proliferation//signal transduction//growth GO:0005319//GO:0008083 lipid transporter activity//growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.38734 BF_2 67.28 1.18 2676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00724 NADH:flavin oxidoreductase / NADH oxidase family GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.38735 BF_2 459.34 3.59 5638 546686533 ERL95731.1 499 5.0e-47 hypothetical protein D910_00173, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38737 BF_2 54.21 1.09 2376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38738 BF_2 507.76 10.49 2312 91084077 XP_968062.1 1175 8.5e-126 PREDICTED: protein odr-4 homolog [Tribolium castaneum]>gi|270008008|gb|EFA04456.1| hypothetical protein TcasGA2_TC014760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWX8 374 2.6e-34 Protein odr-4 homolog OS=Homo sapiens GN=ODR4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38739 BF_2 793.00 48.72 968 478263000 ENN81406.1 667 2.9e-67 hypothetical protein YQE_02222, partial [Dendroctonus ponderosae]>gi|546674219|gb|ERL85652.1| hypothetical protein D910_03069 [Dendroctonus ponderosae] -- -- -- -- -- K03937 NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03937 O43181 428 6.1e-41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial OS=Homo sapiens GN=NDUFS4 PE=1 SV=1 PF04800 ETC complex I subunit conserved region GO:0022900 electron transport chain GO:0016651 oxidoreductase activity, acting on NAD(P)H -- -- KOG3389 NADH:ubiquinone oxidoreductase, NDUFS4/18 kDa subunit Cluster-8309.38741 BF_2 5564.27 100.51 2603 91076104 XP_968648.1 3116 0.0e+00 PREDICTED: 1,4-alpha-glucan-branching enzyme [Tribolium castaneum]>gi|270014582|gb|EFA11030.1| hypothetical protein TcasGA2_TC004619 [Tribolium castaneum] 194754710 XM_001959602.1 211 5.97795e-104 Drosophila ananassae GF11944 (Dana\GF11944), mRNA K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q9D6Y9 2296 4.0e-257 1,4-alpha-glucan-branching enzyme OS=Mus musculus GN=Gbe1 PE=2 SV=1 PF02806//PF02922//PF00128 Alpha amylase, C-terminal all-beta domain//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//Alpha amylase, catalytic domain GO:0005985//GO:0005982//GO:0005975//GO:0005978 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process//glycogen biosynthetic process GO:0004553//GO:0003824//GO:0003844//GO:0043169 hydrolase activity, hydrolyzing O-glycosyl compounds//catalytic activity//1,4-alpha-glucan branching enzyme activity//cation binding -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-8309.38742 BF_2 990.23 9.94 4454 91091526 XP_970162.1 4481 0.0e+00 PREDICTED: tolloid-like protein 1 [Tribolium castaneum]>gi|270001271|gb|EEZ97718.1| hypothetical protein TcasGA2_TC011197 [Tribolium castaneum] 572267902 XM_006611951.1 168 8.23408e-80 PREDICTED: Apis dorsata tolloid-like protein 2-like (LOC102680377), transcript variant X2, mRNA K13046 tok tolkin http://www.genome.jp/dbget-bin/www_bget?ko:K13046 Q9DER7 2700 9.8e-304 Tolloid-like protein 1 OS=Gallus gallus GN=TLL1 PE=2 SV=1 PF00413//PF01400//PF07645//PF00008 Matrixin//Astacin (Peptidase family M12A)//Calcium-binding EGF domain//EGF-like domain GO:0006508 proteolysis GO:0005515//GO:0004222//GO:0005509//GO:0008270 protein binding//metalloendopeptidase activity//calcium ion binding//zinc ion binding GO:0031012 extracellular matrix KOG3714 Meprin A metalloprotease Cluster-8309.38743 BF_2 1219.00 23.30 2476 642914282 XP_008201620.1 841 4.9e-87 PREDICTED: uncharacterized protein LOC103315234 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38744 BF_2 581.18 6.64 3946 91081613 XP_966546.1 1637 3.9e-179 PREDICTED: protein goliath-like [Tribolium castaneum] 768414717 XM_011549573.1 132 7.49645e-60 PREDICTED: Plutella xylostella protein goliath (LOC105380077), mRNA -- -- -- -- Q06003 751 8.7e-78 Protein goliath OS=Drosophila melanogaster GN=gol PE=2 SV=3 PF13639//PF01165//PF12861//PF00335//PF06667//PF14634//PF17123//PF12678//PF00097 Ring finger domain//Ribosomal protein S21//Anaphase-promoting complex subunit 11 RING-H2 finger//Tetraspanin family//Phage shock protein B//zinc-RING finger domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0009271//GO:0016567//GO:0006412//GO:0006355//GO:0042254 phage shock//protein ubiquitination//translation//regulation of transcription, DNA-templated//ribosome biogenesis GO:0005515//GO:0004842//GO:0008270//GO:0003735//GO:0046872 protein binding//ubiquitin-protein transferase activity//zinc ion binding//structural constituent of ribosome//metal ion binding GO:0016021//GO:0005680//GO:0005840 integral component of membrane//anaphase-promoting complex//ribosome KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.38746 BF_2 12.00 1.44 635 546685214 ERL94741.1 268 3.5e-21 hypothetical protein D910_12015 [Dendroctonus ponderosae] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 -- -- -- -- PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38748 BF_2 120.62 2.46 2339 189240983 XP_966935.2 1607 6.9e-176 PREDICTED: DDB1- and CUL4-associated factor 10 homolog [Tribolium castaneum]>gi|270012997|gb|EFA09445.1| hypothetical protein TcasGA2_TC010660 [Tribolium castaneum] -- -- -- -- -- K11802 WDR32 WD repeat-containing protein 32 http://www.genome.jp/dbget-bin/www_bget?ko:K11802 Q9VAT2 713 1.3e-73 DDB1- and CUL4-associated factor 10 homolog OS=Drosophila melanogaster GN=CG1523 PE=1 SV=1 PF00400//PF08447 WD domain, G-beta repeat//PAS fold -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.38750 BF_2 2867.79 118.33 1301 642933239 XP_008197324.1 539 2.7e-52 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38752 BF_2 5327.91 199.21 1406 332372740 AEE61512.1 892 3.4e-93 unknown [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q7PWV1 372 2.7e-34 Aquaporin AQPAn.G OS=Anopheles gambiae GN=AGAP008842 PE=3 SV=4 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.38753 BF_2 3796.45 26.71 6232 589060792 AHK26789.1 2872 0.0e+00 pyruvate carboxylase, partial [Epicauta chinensis] 817070062 XM_012401613.1 189 2.44717e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 2262 8.5e-253 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF00682//PF05896//PF02655//PF07478//PF02786 HMGL-like//Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//ATP-grasp domain//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain GO:0006814//GO:0006118//GO:0055114//GO:0009252//GO:0046436 sodium ion transport//obsolete electron transport//oxidation-reduction process//peptidoglycan biosynthetic process//D-alanine metabolic process GO:0008716//GO:0016655//GO:0046872//GO:0005524//GO:0003824 D-alanine-D-alanine ligase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//metal ion binding//ATP binding//catalytic activity -- -- KOG0369 Pyruvate carboxylase Cluster-8309.38754 BF_2 10.31 0.36 1501 91082025 XP_970311.1 608 3.1e-60 PREDICTED: vacuolar protein sorting-associated protein VTA1 homolog [Tribolium castaneum]>gi|270007383|gb|EFA03831.1| hypothetical protein TcasGA2_TC013947 [Tribolium castaneum] -- -- -- -- -- K12199 VTA1, LIP5 vacuolar protein sorting-associated protein VTA1 http://www.genome.jp/dbget-bin/www_bget?ko:K12199 Q32L63 449 3.5e-43 Vacuolar protein sorting-associated protein VTA1 homolog OS=Bos taurus GN=VTA1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0917 Uncharacterized conserved protein Cluster-8309.38755 BF_2 1261.09 10.40 5360 270010132 EFA06580.1 1966 3.7e-217 hypothetical protein TcasGA2_TC009492 [Tribolium castaneum] 795059302 XM_012017418.1 258 9.24492e-130 PREDICTED: Vollenhovia emeryi F-box/LRR-repeat protein 14 (LOC105564772), mRNA K10280 FBXL14 F-box and leucine-rich repeat protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K10280 Q8N1E6 1336 1.7e-145 F-box/LRR-repeat protein 14 OS=Homo sapiens GN=FBXL14 PE=1 SV=1 PF13516//PF13855//PF12937//PF00560//PF04091//PF00646//PF01529 Leucine Rich repeat//Leucine rich repeat//F-box-like//Leucine Rich Repeat//Exocyst complex subunit Sec15-like//F-box domain//DHHC palmitoyltransferase GO:0006904 vesicle docking involved in exocytosis GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0000145 exocyst KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.38756 BF_2 1082.62 33.26 1649 642920923 XP_008192617.1 1079 8.2e-115 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q5ZK84 587 3.8e-59 Alcohol dehydrogenase [NADP(+)] OS=Gallus gallus GN=AKR1A1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.38757 BF_2 1125.00 67.15 988 91094879 XP_972904.1 607 2.6e-60 PREDICTED: transmembrane protein 256 homolog [Tribolium castaneum]>gi|270006585|gb|EFA03033.1| hypothetical protein TcasGA2_TC010458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4K526 304 1.5e-26 Transmembrane protein 256 homolog OS=Bufo gargarizans PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3472 Predicted small membrane protein Cluster-8309.38760 BF_2 510.66 428.83 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08485 Polysaccharide biosynthesis protein C-terminal GO:0009225//GO:0009103//GO:0006012//GO:0009117 nucleotide-sugar metabolic process//lipopolysaccharide biosynthetic process//galactose metabolic process//nucleotide metabolic process GO:0003978 UDP-glucose 4-epimerase activity -- -- -- -- Cluster-8309.38762 BF_2 12.67 0.31 1992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38764 BF_2 191.57 2.81 3136 91079768 XP_966889.1 876 5.4e-91 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 407 5.4e-38 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF00106//PF13912//PF01073//PF01370//PF00899 short chain dehydrogenase//C2H2-type zinc finger//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//ThiF family GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003824//GO:0050662//GO:0003854//GO:0008641//GO:0046872//GO:0000166 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//small protein activating enzyme activity//metal ion binding//nucleotide binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.38765 BF_2 677.28 11.91 2666 332376294 AEE63287.1 1800 3.3e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 8.99862e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 5.7e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005991//GO:0005985//GO:0005982 trehalose metabolic process//sucrose metabolic process//starch metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.38766 BF_2 1133.92 17.96 2929 642936475 XP_008198451.1 2697 3.5e-302 PREDICTED: LOW QUALITY PROTEIN: G protein-coupled receptor kinase 2 [Tribolium castaneum] 749773827 XM_011143956.1 351 0 PREDICTED: Harpegnathos saltator G protein-coupled receptor kinase 2 (LOC105184862), mRNA K08291 GRK4_5_6 G protein-coupled receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08291 P32866 1848 4.0e-205 G protein-coupled receptor kinase 2 OS=Drosophila melanogaster GN=Gprk2 PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0986 G protein-coupled receptor kinase Cluster-8309.38767 BF_2 140.50 2.91 2307 189234632 XP_001815875.1 989 3.1e-104 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.28205e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38768 BF_2 56.41 0.47 5352 91090858 XP_967143.1 1197 5.5e-128 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] 688710729 LL320824.1 36 2.36794e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 898 1.1e-94 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF02562//PF04851//PF06733//PF00580//PF01580//PF00191//PF00270 PhoH-like protein//Type III restriction enzyme, res subunit//DEAD_2//UvrD/REP helicase N-terminal domain//FtsK/SpoIIIE family//Annexin//DEAD/DEAH box helicase -- -- GO:0005509//GO:0000166//GO:0004003//GO:0003676//GO:0005544//GO:0005524//GO:0016787//GO:0003677 calcium ion binding//nucleotide binding//ATP-dependent DNA helicase activity//nucleic acid binding//calcium-dependent phospholipid binding//ATP binding//hydrolase activity//DNA binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.38769 BF_2 575.10 10.05 2681 752439505 XP_011215366.1 513 5.7e-49 PREDICTED: zinc finger protein 345-like isoform X3 [Ailuropoda melanoleuca] -- -- -- -- -- -- -- -- -- Q6ZMW2 488 1.9e-47 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00130//PF00096//PF02072//PF10503//PF13465//PF05191//PF16622//PF02776//PF13912 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Prepro-orexin//Esterase PHB depolymerase//Zinc-finger double domain//Adenylate kinase, active site lid//zinc-finger C2H2-type//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//C2H2-type zinc finger GO:0007218//GO:0035556//GO:0007631//GO:0006144//GO:0046034 neuropeptide signaling pathway//intracellular signal transduction//feeding behavior//purine nucleobase metabolic process//ATP metabolic process GO:0030976//GO:0004017//GO:0046872 thiamine pyrophosphate binding//adenylate kinase activity//metal ion binding GO:0005576 extracellular region -- -- Cluster-8309.38770 BF_2 2779.76 153.85 1043 557767939 XP_005183655.1 515 1.3e-49 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Musca domestica] 195569934 XM_002102928.1 195 1.8422e-95 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P47815 390 1.7e-36 Eukaryotic translation initiation factor 1A OS=Triticum aestivum PE=1 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.38771 BF_2 679.25 11.70 2716 546676927 ERL87851.1 1793 2.2e-197 hypothetical protein D910_05239 [Dendroctonus ponderosae] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.8e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.38773 BF_2 266.02 5.58 2281 91079828 XP_970042.1 661 3.3e-66 PREDICTED: aprataxin [Tribolium castaneum]>gi|642918234|ref|XP_008191423.1| PREDICTED: aprataxin [Tribolium castaneum]>gi|270004538|gb|EFA00986.1| hypothetical protein TcasGA2_TC003899 [Tribolium castaneum] -- -- -- -- -- K10863 APTX aprataxin http://www.genome.jp/dbget-bin/www_bget?ko:K10863 P61799 437 1.3e-41 Aprataxin OS=Danio rerio GN=aptx PE=2 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- KOG0562 Predicted hydrolase (HIT family) Cluster-8309.38774 BF_2 660.30 12.23 2546 270003153 EEZ99600.1 2889 0.0e+00 hypothetical protein TcasGA2_TC002116 [Tribolium castaneum] 751219340 XM_011164448.1 192 2.13229e-93 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q11002 2438 1.4e-273 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF00648//PF13202//PF00036//PF13833//PF13405//PF13499 Calpain family cysteine protease//EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0006508 proteolysis GO:0004198//GO:0005509 calcium-dependent cysteine-type endopeptidase activity//calcium ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.38776 BF_2 997.48 62.29 957 91090452 XP_967359.1 994 3.4e-105 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|642935319|ref|XP_008197966.1| PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013849|gb|EFA10297.1| hypothetical protein TcasGA2_TC012512 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 413 3.3e-39 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF00931//PF03193//PF00005//PF01926//PF00006//PF13304//PF01637 NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//ATP synthase alpha/beta family, nucleotide-binding domain//AAA domain, putative AbiEii toxin, Type IV TA system//Archaeal ATPase GO:0006810//GO:0006200 transport//obsolete ATP catabolic process GO:0042626//GO:0005525//GO:0016887//GO:0043531//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//ADP binding//GTPase activity//ATP binding GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.38777 BF_2 1365.75 6.50 9080 478260541 ENN80244.1 792 8.6e-81 hypothetical protein YQE_03239, partial [Dendroctonus ponderosae]>gi|546685323|gb|ERL94850.1| hypothetical protein D910_12123 [Dendroctonus ponderosae] 642911796 XM_008202524.1 78 1.80838e-29 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA K18041 PTP4A protein tyrosine phosphatase type IVA http://www.genome.jp/dbget-bin/www_bget?ko:K18041 Q9TSM6 517 2.7e-50 Protein tyrosine phosphatase type IVA 1 OS=Macaca fascicularis GN=PTP4A1 PE=1 SV=1 PF01686//PF00782//PF15750//PF00102 Adenovirus penton base protein//Dual specificity phosphatase, catalytic domain//Ubiquitin-binding zinc-finger//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725//GO:0005198//GO:0043130 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//structural molecule activity//ubiquitin binding -- -- KOG2836 Protein tyrosine phosphatase IVA1 Cluster-8309.38778 BF_2 1615.95 24.42 3055 332375620 AEE62951.1 1020 1.1e-107 unknown [Dendroctonus ponderosae]>gi|546680023|gb|ERL90385.1| hypothetical protein D910_07734 [Dendroctonus ponderosae] 241989293 AK336271.1 277 1.4371e-140 Triticum aestivum cDNA, clone: SET3_K11, cultivar: Chinese Spring K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 694 2.7e-71 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 PF02330//PF14489//PF15088 Mitochondrial glycoprotein//QueF-like protein//NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial GO:0008616 queuosine biosynthetic process GO:0033739 preQ1 synthase activity GO:0005759//GO:0005747//GO:0005739 mitochondrial matrix//mitochondrial respiratory chain complex I//mitochondrion KOG2698 GTP cyclohydrolase I Cluster-8309.38779 BF_2 54.81 0.91 2797 642922794 XP_008193328.1 2003 1.0e-221 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6X935 838 5.0e-88 Inter alpha-trypsin inhibitor, heavy chain 4 OS=Mus musculus GN=Itih4 PE=1 SV=2 PF03357//PF06905//PF08496//PF11965 Snf7//Fas apoptotic inhibitory molecule (FAIM1)//Peptidase family S49 N-terminal//Domain of unknown function (DUF3479) GO:0043066//GO:0007034//GO:0015994 negative regulation of apoptotic process//vacuolar transport//chlorophyll metabolic process GO:0004252//GO:0016851 serine-type endopeptidase activity//magnesium chelatase activity GO:0010007//GO:0005886 magnesium chelatase complex//plasma membrane -- -- Cluster-8309.3878 BF_2 4.00 0.64 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38780 BF_2 614.90 2.02 13025 642924614 XP_008194364.1 1950 6.5e-215 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 D3ZGB1 701 1.8e-71 Nuclear factor of activated T-cells 5 OS=Rattus norvegicus GN=Nfat5 PE=1 SV=1 PF00554//PF01833//PF05933//PF12529//PF00891 Rel homology DNA-binding domain//IPT/TIG domain//Fungal ATP synthase protein 8 (A6L)//Xylosyltransferase C terminal//O-methyltransferase GO:0006024//GO:0015992//GO:0030206//GO:0006355//GO:0015986 glycosaminoglycan biosynthetic process//proton transport//chondroitin sulfate biosynthetic process//regulation of transcription, DNA-templated//ATP synthesis coupled proton transport GO:0005515//GO:0003677//GO:0008171//GO:0003700//GO:0030158//GO:0015078 protein binding//DNA binding//O-methyltransferase activity//transcription factor activity, sequence-specific DNA binding//protein xylosyltransferase activity//hydrogen ion transmembrane transporter activity GO:0005667//GO:0000276 transcription factor complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.38782 BF_2 2085.33 26.83 3538 478250378 ENN70873.1 937 5.1e-98 hypothetical protein YQE_12278, partial [Dendroctonus ponderosae]>gi|546672870|gb|ERL84593.1| hypothetical protein D910_02021 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q495M3 402 2.3e-37 Proton-coupled amino acid transporter 2 OS=Homo sapiens GN=SLC36A2 PE=1 SV=1 PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane KOG1304 Amino acid transporters Cluster-8309.38783 BF_2 14.00 0.61 1248 645041441 XP_008207913.1 895 1.3e-93 PREDICTED: uncharacterized protein LOC100113970 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38785 BF_2 141.01 0.76 8037 801382909 XP_012054587.1 214 8.0e-14 PREDICTED: ATP synthase lipid-binding protein, mitochondrial isoform X1 [Atta cephalotes] 6560654 AF117583.1 108 3.36635e-46 AF117583 Manduca sexta clone pMsmaC26 ATP synthase subunit c mRNA, complete cds K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 Q06055 205 3.6e-14 ATP synthase F(0) complex subunit C2, mitochondrial OS=Homo sapiens GN=ATP5G2 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.38788 BF_2 87.87 1.63 2547 546681329 ERL91443.1 1613 1.5e-176 hypothetical protein D910_08773 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 284 8.0e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF01155//PF00856 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//SET domain GO:0006464 cellular protein modification process GO:0005515//GO:0016151 protein binding//nickel cation binding -- -- -- -- Cluster-8309.38789 BF_2 1025.51 20.39 2391 546681329 ERL91443.1 1890 1.1e-208 hypothetical protein D910_08773 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 284 7.5e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF00856//PF01155 SET domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0016151//GO:0005515 nickel cation binding//protein binding -- -- -- -- Cluster-8309.38790 BF_2 159.18 3.20 2366 852803594 XP_012890580.1 543 1.7e-52 PREDICTED: zinc finger protein 585A-like [Dipodomys ordii] -- -- -- -- -- -- -- -- -- P35789 516 9.3e-51 Zinc finger protein 93 OS=Homo sapiens GN=ZNF93 PE=2 SV=4 PF05151//PF13465//PF00096//PF13912//PF05485//PF16622//PF07776 Photosystem II reaction centre M protein (PsbM)//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//THAP domain//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0019684//GO:0015979 photosynthesis, light reaction//photosynthesis GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0009523//GO:0005634//GO:0016021 photosystem II//nucleus//integral component of membrane -- -- Cluster-8309.38792 BF_2 5795.67 165.06 1756 478256018 ENN76217.1 1979 3.8e-219 hypothetical protein YQE_07184, partial [Dendroctonus ponderosae] 158295753 XM_001688807.1 230 1.09824e-114 Anopheles gambiae str. PEST AGAP006366-PD (AgaP_AGAP006366) mRNA, complete cds K00164 OGDH, sucA 2-oxoglutarate dehydrogenase E1 component http://www.genome.jp/dbget-bin/www_bget?ko:K00164 Q6P6Z8 1493 3.5e-164 2-oxoglutarate dehydrogenase, mitochondrial OS=Xenopus laevis GN=ogdh PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.38794 BF_2 56.07 0.51 4860 264667369 ACY71270.1 584 6.0e-57 ribosomal protein S20 [Chrysomela tremula] 755904867 XM_005191748.2 95 3.42194e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P55828 475 1.1e-45 40S ribosomal protein S20 OS=Drosophila melanogaster GN=RpS20 PE=1 SV=1 PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.38795 BF_2 35.76 0.51 3223 189241130 XP_973380.2 2116 9.1e-235 PREDICTED: melanotransferrin [Tribolium castaneum]>gi|270013329|gb|EFA09777.1| hypothetical protein TcasGA2_TC011919 [Tribolium castaneum] -- -- -- -- -- K06569 MFI2 melanoma-associated antigen p97 http://www.genome.jp/dbget-bin/www_bget?ko:K06569 Q9R0R1 445 2.2e-42 Melanotransferrin OS=Mus musculus GN=Mfi2 PE=2 SV=1 PF01414//PF00172 Delta serrate ligand//Fungal Zn(2)-Cys(6) binuclear cluster domain GO:0007154//GO:0006355//GO:0044699 cell communication//regulation of transcription, DNA-templated//single-organism process GO:0008270//GO:0000981 zinc ion binding//RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.38796 BF_2 2362.00 52.04 2186 332372654 AEE61469.1 2912 0.0e+00 unknown [Dendroctonus ponderosae]>gi|546681887|gb|ERL91896.1| hypothetical protein D910_09219 [Dendroctonus ponderosae] -- -- -- -- -- K00311 ETFDH electron-transferring-flavoprotein dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00311 Q921G7 2327 8.6e-261 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial OS=Mus musculus GN=Etfdh PE=1 SV=1 PF00070//PF12831//PF07992//PF05834//PF01266//PF01494//PF05187 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD dependent oxidoreductase//FAD binding domain//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0071949//GO:0004174//GO:0016705//GO:0016491 FAD binding//electron-transferring-flavoprotein dehydrogenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- KOG2415 Electron transfer flavoprotein ubiquinone oxidoreductase Cluster-8309.38797 BF_2 3250.40 91.88 1767 642939230 XP_008194770.1 356 6.0e-31 PREDICTED: uncharacterized protein LOC656988 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38798 BF_2 120.08 209.19 291 478253273 ENN73644.1 200 1.2e-13 hypothetical protein YQE_09890, partial [Dendroctonus ponderosae]>gi|546676325|gb|ERL87352.1| hypothetical protein D910_04747 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38799 BF_2 3731.47 39.77 4212 642913620 XP_008201091.1 2554 1.9e-285 PREDICTED: moesin/ezrin/radixin homolog 1 isoform X2 [Tribolium castaneum] 347964053 XM_003436981.1 591 0 Anopheles gambiae str. PEST AGAP000562-PB (MOEH_ANOGA) mRNA, complete cds K05763 MSN moesin http://www.genome.jp/dbget-bin/www_bget?ko:K05763 Q170J7 2316 3.1e-259 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF05531//PF03114//PF00887//PF00018//PF14604//PF00769 Nucleopolyhedrovirus P10 protein//BAR domain//Acyl CoA binding protein//SH3 domain//Variant SH3 domain//Ezrin/radixin/moesin family -- -- GO:0000062//GO:0008092//GO:0005515 fatty-acyl-CoA binding//cytoskeletal protein binding//protein binding GO:0019898//GO:0019028//GO:0005737 extrinsic component of membrane//viral capsid//cytoplasm KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.3880 BF_2 6.00 0.32 1080 795010007 XP_011864749.1 476 4.5e-45 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00961//PF01498 LAGLIDADG endonuclease//Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0004519 DNA binding//endonuclease activity -- -- -- -- Cluster-8309.38800 BF_2 645405.33 8652.59 3413 820865920 XP_012349428.1 695 5.7e-70 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105736982 [Apis florea] 32527555 AY210843.1 1631 0 Tenebrio sp. JMM-2003 5.8S ribosomal RNA gene, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- Q8TGM7 161 2.0e-09 Putative uncharacterized protein ART2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ART2 PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38802 BF_2 1050.03 9.98 4688 270014816 EFA11264.1 2443 1.6e-272 hypothetical protein TcasGA2_TC010799 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B6RSP1 355 8.6e-32 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38803 BF_2 511.74 9.98 2432 270000811 EEZ97258.1 3522 0.0e+00 hypothetical protein TcasGA2_TC011058 [Tribolium castaneum] 665799739 XM_008549577.1 371 0 PREDICTED: Microplitis demolitor dynamin-like (LOC103571419), mRNA K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 3043 0.0e+00 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF08023//PF01926//PF01031//PF02212 Frog antimicrobial peptide//50S ribosome-binding GTPase//Dynamin central region//Dynamin GTPase effector domain GO:0006952 defense response GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005576 extracellular region KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.38804 BF_2 2356.38 25.85 4101 91085615 XP_969560.1 1159 1.1e-123 PREDICTED: ubiquitin-conjugating enzyme E2 R2 [Tribolium castaneum]>gi|270010080|gb|EFA06528.1| hypothetical protein TcasGA2_TC009432 [Tribolium castaneum] 332372777 BT126567.1 238 9.26113e-119 Dendroctonus ponderosae clone DPO1125_N09 unknown mRNA K02207 UBE2R, UBC3, CDC34 ubiquitin-conjugating enzyme E2 R http://www.genome.jp/dbget-bin/www_bget?ko:K02207 Q6ZWZ2 843 1.9e-88 Ubiquitin-conjugating enzyme E2 R2 OS=Mus musculus GN=Ube2r2 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515//GO:0005524//GO:0016881 protein binding//ATP binding//acid-amino acid ligase activity -- -- KOG0425 Ubiquitin-protein ligase Cluster-8309.38806 BF_2 1272.00 10.36 5423 91077304 XP_974600.1 875 1.2e-90 PREDICTED: ras-like protein 1 [Tribolium castaneum]>gi|270002086|gb|EEZ98533.1| hypothetical protein TcasGA2_TC001037 [Tribolium castaneum] 642913769 XM_969507.3 44 8.56952e-11 PREDICTED: Tribolium castaneum ras-like protein 1 (LOC663464), mRNA K07827 KRAS, KRAS2 GTPase KRas http://www.genome.jp/dbget-bin/www_bget?ko:K07827 B4NJ72 787 8.0e-82 Ras-like protein 1 OS=Drosophila willistoni GN=Ras85D PE=3 SV=1 PF03193//PF00071//PF04670//PF01926//PF00205//PF00735//PF08477//PF00025//PF02421 Protein of unknown function, DUF258//Ras family//Gtr1/RagA G protein conserved region//50S ribosome-binding GTPase//Thiamine pyrophosphate enzyme, central domain//Septin//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0030976//GO:0000287//GO:0015093//GO:0003924 GTP binding//thiamine pyrophosphate binding//magnesium ion binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.38808 BF_2 939.00 11.50 3704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38809 BF_2 654.98 6.52 4492 642934390 XP_008197640.1 2987 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 7.13883e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.3e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553//PF00620 Acyltransferase//RhoGAP domain GO:0008152//GO:0007165 metabolic process//signal transduction GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.38810 BF_2 91.36 1.04 3947 642913546 XP_008201056.1 1646 3.5e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 1.7e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.38812 BF_2 33.21 1.88 1027 270013544 EFA09992.1 397 6.1e-36 hypothetical protein TcasGA2_TC012159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38814 BF_2 445.67 9.47 2256 478257769 ENN77912.1 1740 2.5e-191 hypothetical protein YQE_05589, partial [Dendroctonus ponderosae] 118344591 NM_001078595.1 107 3.36347e-46 Takifugu rubripes transmembrane protein 57 (tmem57), mRNA >gnl|BL_ORD_ID|675048 Takifugu rubripes macoilin-2 mRNA, complete cds -- -- -- -- Q2TLY1 912 1.1e-96 Macoilin-2 OS=Danio rerio GN=tmem57b PE=2 SV=1 PF09726 Transmembrane protein -- -- -- -- GO:0016021 integral component of membrane KOG1821 Uncharacterized conserved protein Cluster-8309.38815 BF_2 1074.59 20.16 2517 91080689 XP_975235.1 1580 1.0e-172 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [Tribolium castaneum]>gi|270006426|gb|EFA02874.1| hypothetical protein TcasGA2_TC007967 [Tribolium castaneum] 642919565 XM_970142.2 154 2.80469e-72 PREDICTED: Tribolium castaneum NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (LOC664127), mRNA K03953 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03953 P34943 747 1.6e-77 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Bos taurus GN=NDUFA9 PE=1 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0008210//GO:0044237 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//estrogen metabolic process//cellular metabolic process GO:0000166//GO:0003824//GO:0050662//GO:0003854//GO:0016616 nucleotide binding//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit Cluster-8309.38816 BF_2 1051.47 5.61 8130 91087319 XP_975585.1 1392 2.0e-150 PREDICTED: solute carrier family 46 member 3-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q5F4B8 257 3.4e-20 Solute carrier family 46 member 3 OS=Gallus gallus GN=SLC46A3 PE=2 SV=1 PF00608//PF07690//PF03869//PF02285 Adenoviral fibre protein (repeat/shaft region)//Major Facilitator Superfamily//Arc-like DNA binding domain//Cytochrome oxidase c subunit VIII GO:0055085//GO:0006123//GO:0019062//GO:0009405//GO:0015992//GO:0007155 transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//virion attachment to host cell//pathogenesis//proton transport//cell adhesion GO:0003677//GO:0004129 DNA binding//cytochrome-c oxidase activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.38817 BF_2 2128.00 30.52 3204 189238710 XP_969341.2 1002 1.3e-105 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050 Flagellar FliJ protein GO:0006935//GO:0071973 chemotaxis//bacterial-type flagellum-dependent cell motility GO:0003774 motor activity GO:0016020//GO:0009288 membrane//bacterial-type flagellum -- -- Cluster-8309.38818 BF_2 183.31 6.65 1440 189237561 XP_974680.2 1046 4.8e-111 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38819 BF_2 429.03 3.32 5691 197276682 NP_001127850.1 2992 0.0e+00 smoothened precursor [Tribolium castaneum]>gi|270012713|gb|EFA09161.1| smoothened [Tribolium castaneum] 645012677 XM_001604820.3 303 9.47841e-155 PREDICTED: Nasonia vitripennis uncharacterized LOC100119467 (LOC100119467), mRNA K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 P91682 1824 4.8e-202 Protein smoothened OS=Drosophila melanogaster GN=smo PE=1 SV=1 PF06573//PF01534//PF01392 Churchill protein//Frizzled/Smoothened family membrane region//Fz domain GO:0007275//GO:0007166//GO:0007186//GO:0045893//GO:0007224 multicellular organismal development//cell surface receptor signaling pathway//G-protein coupled receptor signaling pathway//positive regulation of transcription, DNA-templated//smoothened signaling pathway GO:0005515//GO:0004930//GO:0008270 protein binding//G-protein coupled receptor activity//zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.38820 BF_2 46.09 1.01 2202 189241329 XP_001808868.1 187 3.0e-11 PREDICTED: uncharacterized protein LOC100142578 [Tribolium castaneum]>gi|270014077|gb|EFA10525.1| hypothetical protein TcasGA2_TC012777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38821 BF_2 31.99 0.51 2927 668462282 KFB49751.1 507 3.1e-48 hypothetical protein ZHAS_00017764 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q27081 285 7.0e-24 Clotting factor B OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38823 BF_2 1321.00 13.81 4289 642930971 XP_008196161.1 2103 3.9e-233 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103313779 [Tribolium castaneum] 642930970 XM_008197939.1 332 5.39494e-171 PREDICTED: Tribolium castaneum uncharacterized LOC103313779 (LOC103313779), mRNA K04650 NCOR1, N-CoR nuclear receptor co-repressor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04650 O75376 895 1.9e-94 Nuclear receptor corepressor 1 OS=Homo sapiens GN=NCOR1 PE=1 SV=2 PF01775 Ribosomal L18ae/LX protein domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1878 Nuclear receptor coregulator SMRT/SMRTER, contains Myb-like domains Cluster-8309.38824 BF_2 2240.66 25.08 4025 91086855 XP_974363.1 1684 1.4e-184 PREDICTED: zinc finger protein 91 [Tribolium castaneum]>gi|270009694|gb|EFA06142.1| hypothetical protein TcasGA2_TC008986 [Tribolium castaneum] -- -- -- -- -- K00079 CBR1 carbonyl reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00079 Q3SZD7 562 7.3e-56 Carbonyl reductase [NADPH] 1 OS=Bos taurus GN=CBR1 PE=2 SV=1 PF01370//PF13912//PF00106//PF00096//PF13465 NAD dependent epimerase/dehydratase family//C2H2-type zinc finger//short chain dehydrogenase//Zinc finger, C2H2 type//Zinc-finger double domain GO:0008152 metabolic process GO:0050662//GO:0003824//GO:0016491//GO:0046872 coenzyme binding//catalytic activity//oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.38825 BF_2 307.03 0.55 23673 270014225 EFA10673.1 9007 0.0e+00 muscle-specific protein 300 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 816 1.5e-84 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF00435//PF00837//PF14867//PF10541 Spectrin repeat//Iodothyronine deiodinase//Lantibiotic alpha//Nuclear envelope localisation domain GO:0050830//GO:0055114 defense response to Gram-positive bacterium//oxidation-reduction process GO:0004800//GO:0005515 thyroxine 5'-deiodinase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.38826 BF_2 269.00 10.97 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38827 BF_2 1851.23 22.27 3764 546685733 ERL95188.1 972 4.8e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 3.2e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.38829 BF_2 21.26 0.65 1646 642928322 XP_008195533.1 577 1.3e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.4e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.38831 BF_2 1509.44 30.74 2341 167234457 NP_001107844.1 1519 1.1e-165 eukaryotic translation initiation factor 5 [Tribolium castaneum]>gi|642919625|ref|XP_008191995.1| PREDICTED: eukaryotic translation initiation factor 5 isoform X1 [Tribolium castaneum]>gi|270005452|gb|EFA01900.1| hypothetical protein TcasGA2_TC007510 [Tribolium castaneum] 167234456 NM_001114372.1 122 1.60193e-54 Tribolium castaneum eukaryotic translation initiation factor 5 (Eif5), mRNA K03262 EIF5 translation initiation factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03262 Q9VXK6 1299 1.5e-141 Eukaryotic translation initiation factor 5 OS=Drosophila melanogaster GN=eIF5 PE=1 SV=1 PF01873//PF02020//PF14489 Domain found in IF2B/IF5//eIF4-gamma/eIF5/eIF2-epsilon//QueF-like protein GO:0006413//GO:0016070//GO:0006446//GO:0008616 translational initiation//RNA metabolic process//regulation of translational initiation//queuosine biosynthetic process GO:0033739//GO:0005515//GO:0003743 preQ1 synthase activity//protein binding//translation initiation factor activity GO:0005840 ribosome KOG2767 Translation initiation factor 5 (eIF-5) Cluster-8309.38832 BF_2 8.40 0.89 680 91088569 XP_973042.1 388 4.5e-35 PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011703|gb|EFA08151.1| hypothetical protein TcasGA2_TC005769 [Tribolium castaneum] -- -- -- -- -- K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q16836 292 2.5e-25 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3 PF00725//PF02276//PF02737 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Photosynthetic reaction centre cytochrome C subunit//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0018874//GO:0006633//GO:0006631//GO:0006552//GO:0006550//GO:0006574//GO:0006568//GO:0006118//GO:0006554//GO:0019684//GO:0055114 benzoate metabolic process//fatty acid biosynthetic process//fatty acid metabolic process//leucine catabolic process//isoleucine catabolic process//valine catabolic process//tryptophan metabolic process//obsolete electron transport//lysine catabolic process//photosynthesis, light reaction//oxidation-reduction process GO:0016491//GO:0070403//GO:0009055//GO:0020037//GO:0003857//GO:0005506 oxidoreductase activity//NAD+ binding//electron carrier activity//heme binding//3-hydroxyacyl-CoA dehydrogenase activity//iron ion binding GO:0030077 plasma membrane light-harvesting complex KOG1683 Hydroxyacyl-CoA dehydrogenase/enoyl-CoA hydratase Cluster-8309.38833 BF_2 1589.51 46.47 1718 91088569 XP_973042.1 1240 1.8e-133 PREDICTED: hydroxyacyl-coenzyme A dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011703|gb|EFA08151.1| hypothetical protein TcasGA2_TC005769 [Tribolium castaneum] -- -- -- -- -- K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q9WVK7 921 7.3e-98 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Hadh PE=2 SV=1 PF02276//PF03446//PF01134//PF13241//PF11965//PF00725//PF07992//PF02737//PF00185//PF03721//PF00070//PF01210//PF01266//PF03435//PF12831//PF02254 Photosynthetic reaction centre cytochrome C subunit//NAD binding domain of 6-phosphogluconate dehydrogenase//Glucose inhibited division protein A//Putative NAD(P)-binding//Domain of unknown function (DUF3479)//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//TrkA-N domain GO:0055114//GO:0006779//GO:0006554//GO:0006118//GO:0006568//GO:0015994//GO:0019354//GO:0006098//GO:0006633//GO:0018874//GO:0046168//GO:0006552//GO:0006550//GO:0006574//GO:0019684//GO:0008033//GO:0019521//GO:0006813//GO:0006520//GO:0006631 oxidation-reduction process//porphyrin-containing compound biosynthetic process//lysine catabolic process//obsolete electron transport//tryptophan metabolic process//chlorophyll metabolic process//siroheme biosynthetic process//pentose-phosphate shunt//fatty acid biosynthetic process//benzoate metabolic process//glycerol-3-phosphate catabolic process//leucine catabolic process//isoleucine catabolic process//valine catabolic process//photosynthesis, light reaction//tRNA processing//D-gluconate metabolic process//potassium ion transport//cellular amino acid metabolic process//fatty acid metabolic process GO:0016616//GO:0005506//GO:0016743//GO:0016491//GO:0043115//GO:0020037//GO:0016597//GO:0016851//GO:0003857//GO:0004616//GO:0051287//GO:0070403//GO:0009055//GO:0050660 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//iron ion binding//carboxyl- or carbamoyltransferase activity//oxidoreductase activity//precorrin-2 dehydrogenase activity//heme binding//amino acid binding//magnesium chelatase activity//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//NAD+ binding//electron carrier activity//flavin adenine dinucleotide binding GO:0010007//GO:0030077 magnesium chelatase complex//plasma membrane light-harvesting complex KOG2304 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.38834 BF_2 25.69 11.10 382 668447831 KFB37571.1 138 2.5e-06 AGAP011345-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07851//PF10147 TMPIT-like protein//Growth arrest and DNA-damage-inducible proteins-interacting protein 1 GO:0007049 cell cycle -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.38835 BF_2 601.60 23.72 1348 189234912 XP_969611.2 1065 2.8e-113 PREDICTED: poly(rC)-binding protein 3 isoform X3 [Tribolium castaneum] 642914804 XM_964518.3 498 0 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X5, mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57722 455 6.3e-44 Poly(rC)-binding protein 3 OS=Mus musculus GN=Pcbp3 PE=2 SV=3 PF07650//PF00013//PF13014//PF13184 KH domain//KH domain//KH domain//NusA-like KH domain -- -- GO:0003723 RNA binding -- -- KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.38836 BF_2 709.55 6.01 5228 91076774 XP_973840.1 1189 4.6e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.75028e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 5.9e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF06309//PF07728//PF04106//PF16094 Torsin//AAA domain (dynein-related subfamily)//Autophagy protein Apg5//Proteasome assembly chaperone 4 GO:0043248//GO:0006914 proteasome assembly//autophagy GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0005783//GO:0005737 endoplasmic reticulum//cytoplasm KOG2170 ATPase of the AAA+ superfamily Cluster-8309.38837 BF_2 624.12 3.15 8567 642918090 XP_008193957.1 2255 1.8e-250 PREDICTED: uncharacterized protein LOC103313170 isoform X3 [Tribolium castaneum] -- -- -- -- -- K17480 AATK, LMTK1 lemur tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17480 Q6ZMQ8 601 4.7e-60 Serine/threonine-protein kinase LMTK1 OS=Homo sapiens GN=AATK PE=1 SV=2 PF00069//PF07714//PF14991 Protein kinase domain//Protein tyrosine kinase//Protein melan-A GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0042470 melanosome -- -- Cluster-8309.38841 BF_2 104.15 0.34 13140 642918534 XP_008191512.1 3764 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.79358e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1207 3.9e-130 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF13895//PF05461//PF02383 Immunoglobulin domain//Apolipoprotein L//SacI homology domain GO:0042157//GO:0006869 lipoprotein metabolic process//lipid transport GO:0042578//GO:0008289//GO:0005515 phosphoric ester hydrolase activity//lipid binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.38842 BF_2 911.44 22.20 2005 546674732 ERL86041.1 1235 8.1e-133 hypothetical protein D910_03455 [Dendroctonus ponderosae] 808119683 XM_012307943.1 60 3.99817e-20 PREDICTED: Bombus terrestris 40S ribosomal protein S28 (LOC105665663), mRNA K07050 AARSD1, ALAX misacylated tRNA(Ala) deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K07050 Q7ZYJ9 822 2.6e-86 Alanyl-tRNA editing protein Aarsd1-B OS=Xenopus laevis GN=aarsd1-b PE=2 SV=1 PF01176//PF07973//PF03367//PF01200//PF01411 Translation initiation factor 1A / IF-1//Threonyl and Alanyl tRNA synthetase second additional domain//ZPR1 zinc-finger domain//Ribosomal protein S28e//tRNA synthetases class II (A) GO:0042254//GO:0006522//GO:0006413//GO:0043039//GO:0006419//GO:0006446//GO:0006412//GO:0006531 ribosome biogenesis//alanine metabolic process//translational initiation//tRNA aminoacylation//alanyl-tRNA aminoacylation//regulation of translational initiation//translation//aspartate metabolic process GO:0008270//GO:0000166//GO:0003735//GO:0016876//GO:0003743//GO:0005524//GO:0003723//GO:0004813 zinc ion binding//nucleotide binding//structural constituent of ribosome//ligase activity, forming aminoacyl-tRNA and related compounds//translation initiation factor activity//ATP binding//RNA binding//alanine-tRNA ligase activity GO:0005622//GO:0005840 intracellular//ribosome KOG3502 40S ribosomal protein S28 Cluster-8309.38843 BF_2 19.65 0.34 2740 546683268 ERL93100.1 388 1.8e-34 hypothetical protein D910_10402 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38844 BF_2 614.19 3.34 7987 91079889 XP_968047.1 4173 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 6.89145e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 2.5e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF14560//PF00240//PF00443 Ubiquitin-like domain//Ubiquitin family//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.38847 BF_2 796.02 24.60 1641 91076824 XP_967870.1 591 3.1e-58 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 435 1.6e-41 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.38849 BF_2 687.84 3.44 8641 91084687 XP_968830.1 2631 4.7e-294 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] 831284033 XM_012817767.1 98 1.31141e-40 PREDICTED: Clupea harengus myotubularin-related protein 3-like (LOC105891591), mRNA K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q13615 1526 2.6e-167 Myotubularin-related protein 3 OS=Homo sapiens GN=MTMR3 PE=1 SV=3 PF00782//PF01363//PF00400//PF07646//PF00102 Dual specificity phosphatase, catalytic domain//FYVE zinc finger//WD domain, G-beta repeat//Kelch motif//Protein-tyrosine phosphatase GO:0035335//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0046872//GO:0004725//GO:0005515//GO:0008138 metal ion binding//protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- KOG4471 Phosphatidylinositol 3-phosphate 3-phosphatase myotubularin MTM1 Cluster-8309.38850 BF_2 41.00 2.34 1019 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 208 2.1e-15 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.38851 BF_2 1213.68 34.24 1770 91091796 XP_970426.1 1783 2.0e-196 PREDICTED: dynactin subunit 4 [Tribolium castaneum]>gi|270001091|gb|EEZ97538.1| hypothetical protein TcasGA2_TC011388 [Tribolium castaneum] -- -- -- -- -- K10426 DCTN4 dynactin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10426 Q9UJW0 746 1.5e-77 Dynactin subunit 4 OS=Homo sapiens GN=DCTN4 PE=1 SV=1 PF02529//PF05502 Cytochrome B6-F complex subunit 5//Dynactin p62 family -- -- -- -- GO:0005869//GO:0009512 dynactin complex//cytochrome b6f complex KOG3896 Dynactin, subunit p62 Cluster-8309.38852 BF_2 78.03 1.06 3367 642920452 XP_008192356.1 661 4.9e-66 PREDICTED: protein croquemort isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 460 4.1e-44 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.38853 BF_2 776.44 3.46 9667 478252680 ENN73076.1 475 5.2e-44 hypothetical protein YQE_10280, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38854 BF_2 6259.08 21.26 12602 270001906 EEZ98353.1 491 9.5e-46 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07716//PF00170//PF04384//PF03131 Basic region leucine zipper//bZIP transcription factor//Iron-sulphur cluster assembly//bZIP Maf transcription factor GO:0006355//GO:0016226 regulation of transcription, DNA-templated//iron-sulfur cluster assembly GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.38855 BF_2 5.00 1.35 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38856 BF_2 219.99 14.61 917 642913524 XP_008201050.1 213 1.2e-14 PREDICTED: venom allergen 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38857 BF_2 34.09 1.44 1276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38859 BF_2 3582.07 113.62 1606 350406035 XP_003487634.1 231 1.7e-16 PREDICTED: pro-resilin [Bombus impatiens] 642925500 XM_963805.3 51 3.21102e-15 PREDICTED: Tribolium castaneum pro-resilin (LOC657340), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38860 BF_2 370.33 64.03 529 270013347 EFA09795.1 558 6.8e-55 hypothetical protein TcasGA2_TC011937 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 418 4.8e-40 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38861 BF_2 1713.00 32.06 2522 642935430 XP_008198007.1 885 3.9e-92 PREDICTED: LOW QUALITY PROTEIN: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum] 195450978 XM_002072679.1 142 1.31681e-65 Drosophila willistoni GK13751 (Dwil\GK13751), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 663 8.9e-68 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.38865 BF_2 115.09 0.80 6286 478249797 ENN70304.1 1981 8.0e-219 hypothetical protein YQE_12815, partial [Dendroctonus ponderosae] -- -- -- -- -- K17785 IMMT, FCJ1, MNOS2 mitofilin http://www.genome.jp/dbget-bin/www_bget?ko:K17785 P91928 1173 1.6e-126 MICOS complex subunit Mic60 OS=Drosophila melanogaster GN=Mitofilin PE=1 SV=4 PF10759//PF01632//PF01557 Protein of unknown function (DUF2587)//Ribosomal protein L35//Fumarylacetoacetate (FAA) hydrolase family GO:0042254//GO:0008152//GO:0061136//GO:0006412 ribosome biogenesis//metabolic process//regulation of proteasomal protein catabolic process//translation GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0005622 ribosome//intracellular KOG1854 Mitochondrial inner membrane protein (mitofilin) Cluster-8309.38867 BF_2 879.88 7.33 5310 642926171 XP_008194814.1 2757 7.0e-309 PREDICTED: vinculin isoform X4 [Tribolium castaneum]>gi|270008539|gb|EFA04987.1| hypothetical protein TcasGA2_TC015066 [Tribolium castaneum] 665389295 NM_001297885.1 65 1.77793e-22 Drosophila melanogaster vinculin (Vinc), transcript variant C, mRNA K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 2024 2.9e-225 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF04513//PF09141//PF01442 Vinculin family//Baculovirus polyhedron envelope protein, PEP, C terminus//Talin, middle domain//Apolipoprotein A1/A4/E domain GO:0042157//GO:0007016//GO:0006869//GO:0007155 lipoprotein metabolic process//cytoskeletal anchoring at plasma membrane//lipid transport//cell adhesion GO:0008289//GO:0005198//GO:0051015//GO:0005200 lipid binding//structural molecule activity//actin filament binding//structural constituent of cytoskeleton GO:0005925//GO:0005856//GO:0019028//GO:0001726//GO:0019031//GO:0015629//GO:0005576 focal adhesion//cytoskeleton//viral capsid//ruffle//viral envelope//actin cytoskeleton//extracellular region KOG3681 Alpha-catenin Cluster-8309.38869 BF_2 1555.00 31.16 2375 91077746 XP_966706.1 2391 8.6e-267 PREDICTED: uncharacterized protein LOC655102 [Tribolium castaneum]>gi|270001518|gb|EEZ97965.1| hypothetical protein TcasGA2_TC000357 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38870 BF_2 8013.10 142.77 2635 546684091 ERL93810.1 2181 2.1e-242 hypothetical protein D910_11096 [Dendroctonus ponderosae] -- -- -- -- -- K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 P45844 1291 1.4e-140 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF03193//PF00005//PF13304//PF01926//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter -- -- GO:0003924//GO:0016887//GO:0005525//GO:0005524 GTPase activity//ATPase activity//GTP binding//ATP binding GO:0016020 membrane -- -- Cluster-8309.38871 BF_2 27.27 0.31 4009 478263722 ENN82025.1 960 1.3e-100 hypothetical protein YQE_01600, partial [Dendroctonus ponderosae] 769857176 XM_011641913.1 129 3.54396e-58 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S23 (LOC105429139), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q6EV23 449 9.2e-43 40S ribosomal protein S23 OS=Papilio dardanus GN=RpS23 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1749 40S ribosomal protein S23 Cluster-8309.38872 BF_2 1867.66 13.40 6119 642910289 XP_008198706.1 2720 1.6e-304 PREDICTED: U2 snRNP-associated SURP motif-containing protein-like [Tribolium castaneum] -- -- -- -- -- K12842 SR140 U2-associated protein SR140 http://www.genome.jp/dbget-bin/www_bget?ko:K12842 Q5R7X2 1646 2.2e-181 U2 snRNP-associated SURP motif-containing protein OS=Pongo abelii GN=U2SURP PE=2 SV=1 PF11051//PF00076//PF16367//PF01501//PF01805 Mannosyltransferase putative//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Glycosyl transferase family 8//Surp module GO:0006486//GO:0006396 protein glycosylation//RNA processing GO:0016757//GO:0003723//GO:0003676 transferase activity, transferring glycosyl groups//RNA binding//nucleic acid binding -- -- KOG0151 Predicted splicing regulator, contains RRM, SWAP and RPR domains Cluster-8309.38874 BF_2 395.58 7.46 2505 642929001 XP_008195650.1 2028 1.1e-224 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 845 7.0e-89 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF08686//PF05986 PLAC (protease and lacunin) domain//ADAM-TS Spacer 1 -- -- GO:0004222//GO:0008233 metalloendopeptidase activity//peptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.38876 BF_2 988.90 4.50 9476 617652370 XP_007534385.1 565 1.9e-54 PREDICTED: zinc finger protein 14-like [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- Q03938 512 1.1e-49 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF13465//PF00096//PF13912//PF00230//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Major intrinsic protein//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) GO:0006810 transport GO:0046872//GO:0005215//GO:0008270 metal ion binding//transporter activity//zinc ion binding GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.38877 BF_2 40.83 2.77 904 642915081 XP_008190403.1 488 1.5e-46 PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|642915083|ref|XP_008190404.1| PREDICTED: aquaporin AQPAn.G [Tribolium castaneum]>gi|270002357|gb|EEZ98804.1| hypothetical protein TcasGA2_TC001374 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q23808 295 1.5e-25 Aquaporin AQPcic OS=Cicadella viridis GN=AQP PE=1 SV=1 PF00230//PF17070 Major intrinsic protein//30S ribosomal protein Thx GO:0006810 transport GO:0005215 transporter activity GO:0005840//GO:0016020 ribosome//membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.38878 BF_2 229.96 3.23 3261 91088017 XP_974079.1 1338 1.5e-144 PREDICTED: graves disease carrier protein [Tribolium castaneum]>gi|270011890|gb|EFA08338.1| hypothetical protein TcasGA2_TC005981 [Tribolium castaneum] -- -- -- -- -- K15084 SLC25A16, GDA, LEU5 solute carrier family 25 (mitochondrial carrier protein), member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15084 Q8C0K5 814 3.6e-85 Graves disease carrier protein homolog OS=Mus musculus GN=Slc25a16 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0005743//GO:0016021 mitochondrial inner membrane//integral component of membrane KOG0752 Mitochondrial solute carrier protein Cluster-8309.38879 BF_2 207.17 1.36 6641 91085003 XP_973266.1 2982 0.0e+00 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 194742159 XM_001953538.1 227 1.95948e-112 Drosophila ananassae GF17161 (Dana\GF17161), mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 2563 1.1e-287 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF02535//PF05693//PF00439 ZIP Zinc transporter//Glycogen synthase//Bromodomain GO:0005985//GO:0055085//GO:0030001//GO:0005982//GO:0005978 sucrose metabolic process//transmembrane transport//metal ion transport//starch metabolic process//glycogen biosynthetic process GO:0004373//GO:0005515//GO:0046873 glycogen (starch) synthase activity//protein binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3742 Glycogen synthase Cluster-8309.38881 BF_2 1770.00 27.92 2939 478261514 ENN80859.1 850 5.2e-88 hypothetical protein YQE_02725, partial [Dendroctonus ponderosae] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P13582 498 1.4e-48 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.38882 BF_2 20.77 0.52 1949 642916768 XP_008192537.1 406 1.1e-36 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V3B7 326 8.2e-29 Peptidoglycan-recognition protein SC1a/b OS=Drosophila melanogaster GN=PGRP-SC1a PE=1 SV=1 PF01480//PF01510 PWI domain//N-acetylmuramoyl-L-alanine amidase GO:0006397//GO:0009252//GO:0006807//GO:0009253 mRNA processing//peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.38883 BF_2 200.66 2.47 3691 642916768 XP_008192537.1 418 8.1e-38 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V3B7 326 1.6e-28 Peptidoglycan-recognition protein SC1a/b OS=Drosophila melanogaster GN=PGRP-SC1a PE=1 SV=1 PF01510//PF01480 N-acetylmuramoyl-L-alanine amidase//PWI domain GO:0006397//GO:0009252//GO:0006807//GO:0009253 mRNA processing//peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.38888 BF_2 519.77 2.35 9530 332375166 AEE62724.1 996 2.0e-104 unknown [Dendroctonus ponderosae]>gi|478252403|gb|ENN72829.1| hypothetical protein YQE_10632, partial [Dendroctonus ponderosae]>gi|546680735|gb|ERL90961.1| hypothetical protein D910_08303 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 736 1.2e-75 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF09107//PF01370//PF03435//PF03015//PF13855//PF01118//PF01073//PF07244//PF10371//PF08506 Elongation factor SelB, winged helix//NAD dependent epimerase/dehydratase family//Saccharopine dehydrogenase NADP binding domain//Male sterility protein//Leucine rich repeat//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//Surface antigen variable number repeat//Domain of unknown function//Cse1 GO:0008209//GO:0001514//GO:0006694//GO:0055114//GO:0008207//GO:0006448//GO:0006886//GO:0008210 androgen metabolic process//selenocysteine incorporation//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//regulation of translational elongation//intracellular protein transport//estrogen metabolic process GO:0016903//GO:0016620//GO:0080019//GO:0016616//GO:0050662//GO:0003854//GO:0005525//GO:0003746//GO:0051287//GO:0005515//GO:0016491//GO:0003824//GO:0003723 oxidoreductase activity, acting on the aldehyde or oxo group of donors//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//GTP binding//translation elongation factor activity//NAD binding//protein binding//oxidoreductase activity//catalytic activity//RNA binding GO:0005737//GO:0005840//GO:0019867 cytoplasm//ribosome//outer membrane KOG1221 Acyl-CoA reductase Cluster-8309.38889 BF_2 379.76 3.01 5570 642923061 XP_008200515.1 1804 2.4e-198 PREDICTED: sphingomyelin synthase-related 1-like [Tribolium castaneum]>gi|270006596|gb|EFA03044.1| hypothetical protein TcasGA2_TC010470 [Tribolium castaneum] 755974579 XM_011309074.1 145 6.2959e-67 PREDICTED: Fopius arisanus sphingomyelin synthase-related 1 (LOC105269082), mRNA -- -- -- -- Q9VS60 1131 1.1e-121 Sphingomyelin synthase-related 1 OS=Drosophila melanogaster GN=SMSr PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3330 Transport protein particle (TRAPP) complex subunit Cluster-8309.38890 BF_2 626.50 10.44 2797 642936148 XP_008198317.1 2326 3.5e-259 PREDICTED: F-box/LRR-repeat protein 20 isoform X2 [Tribolium castaneum] 571506739 XM_397111.4 230 1.76135e-114 PREDICTED: Apis mellifera f-box/LRR-repeat protein 2-like (LOC413670), transcript variant X1, mRNA -- -- -- -- Q8BH16 205 1.3e-14 F-box/LRR-repeat protein 2 OS=Mus musculus GN=Fbxl2 PE=1 SV=1 PF13639//PF12937//PF00646//PF15966 Ring finger domain//F-box-like//F-box domain//F-box -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.38892 BF_2 95.78 1.35 3253 91076670 XP_971562.1 2366 9.4e-264 PREDICTED: ATP-binding cassette sub-family F member 1 [Tribolium castaneum]>gi|270002367|gb|EEZ98814.1| hypothetical protein TcasGA2_TC004420 [Tribolium castaneum] 194889494 XM_001977061.1 234 1.22643e-116 Drosophila erecta GG18434 (Dere\GG18434), mRNA K06184 ABCF1 ATP-binding cassette, subfamily F, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06184 Q767L0 1714 1.5e-189 ATP-binding cassette sub-family F member 1 OS=Sus scrofa GN=ABCF1 PE=3 SV=1 PF07213//PF00004//PF13304//PF01926//PF00488//PF08477//PF07728//PF00910//PF01008//PF02367//PF00005//PF03193//PF03266 DAP10 membrane protein//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//MutS domain V//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//RNA helicase//Initiation factor 2 subunit family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258//NTPase GO:0014068//GO:0006298//GO:0007264//GO:0002949//GO:0044237//GO:0006200//GO:0007165//GO:0050776 positive regulation of phosphatidylinositol 3-kinase signaling//mismatch repair//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//cellular metabolic process//obsolete ATP catabolic process//signal transduction//regulation of immune response GO:0003723//GO:0003724//GO:0005525//GO:0043548//GO:0003924//GO:0005524//GO:0098519//GO:0005102//GO:0030983//GO:0016887 RNA binding//RNA helicase activity//GTP binding//phosphatidylinositol 3-kinase binding//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//receptor binding//mismatched DNA binding//ATPase activity GO:0016020 membrane KOG0927 Predicted transporter (ABC superfamily) Cluster-8309.38893 BF_2 25.78 0.35 3398 189238048 XP_001811309.1 1686 6.9e-185 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 2.4e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF01073//PF01370//PF03015 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//Male sterility protein GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0050662//GO:0003824//GO:0003854//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.38894 BF_2 324.92 2.58 5557 546672885 ERL84608.1 3017 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1608 5.2e-177 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00107//PF00106//PF00975 Zinc-binding dehydrogenase//short chain dehydrogenase//Thioesterase domain GO:0008152//GO:0055114//GO:0009058 metabolic process//oxidation-reduction process//biosynthetic process GO:0016788//GO:0016491 hydrolase activity, acting on ester bonds//oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.38895 BF_2 1565.63 30.59 2428 91086105 XP_967675.1 1968 9.9e-218 PREDICTED: long-chain fatty acid transport protein 4-like [Tribolium castaneum] 674034499 XM_008840881.1 44 3.80793e-11 PREDICTED: Nannospalax galili solute carrier family 27 (fatty acid transporter), member 6 (Slc27a6), mRNA K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q91VE0 1415 5.4e-155 Long-chain fatty acid transport protein 4 OS=Mus musculus GN=Slc27a4 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.38896 BF_2 34.06 0.39 3964 189236750 XP_975130.2 1393 7.6e-151 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 436 2.9e-41 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.38897 BF_2 1752.00 38.82 2175 642922463 XP_008193182.1 2033 2.6e-225 PREDICTED: integrin beta-PS [Tribolium castaneum] -- -- -- -- -- K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 1437 1.4e-157 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.38898 BF_2 2507.31 15.66 6983 642920095 XP_008192202.1 1742 4.6e-191 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 7.73392e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.1e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.38900 BF_2 1920.13 10.67 7812 546679672 ERL90099.1 3727 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 1922 2.8e-213 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF08141//PF02826//PF03446//PF00389//PF03493 Small acid-soluble spore protein H family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit GO:0006813//GO:0006098//GO:0008152//GO:0055114//GO:0019521//GO:0030436 potassium ion transport//pentose-phosphate shunt//metabolic process//oxidation-reduction process//D-gluconate metabolic process//asexual sporulation GO:0015269//GO:0016616//GO:0051287//GO:0004616 calcium-activated potassium channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//phosphogluconate dehydrogenase (decarboxylating) activity GO:0042601//GO:0016020 endospore-forming forespore//membrane KOG1998 Signaling protein DOCK180 Cluster-8309.38901 BF_2 29.55 0.64 2204 728416984 AIY68330.1 1047 5.6e-111 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 554 3.4e-55 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.38902 BF_2 3682.34 269.38 859 270003816 EFA00264.1 1006 1.2e-106 hypothetical protein TcasGA2_TC003097 [Tribolium castaneum] 255522810 NM_001163846.1 287 1.08488e-146 Tribolium castaneum longitudinals lacking (Lola), transcript variant 9, mRNA -- -- -- -- Q9V5M6 553 1.7e-55 Longitudinals lacking protein, isoforms J/P/Q/S/Z OS=Drosophila melanogaster GN=lola PE=1 SV=4 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38903 BF_2 676.83 4.18 7064 642915492 XP_008190639.1 723 6.7e-73 PREDICTED: glycerol kinase [Tribolium castaneum]>gi|642915494|ref|XP_008190640.1| PREDICTED: glycerol kinase [Tribolium castaneum]>gi|270003860|gb|EFA00308.1| hypothetical protein TcasGA2_TC003143 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q64516 446 3.6e-42 Glycerol kinase OS=Mus musculus GN=Gk PE=2 SV=2 PF00370//PF05480//PF02782 FGGY family of carbohydrate kinases, N-terminal domain//Staphylococcus haemolytic protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0006072//GO:0009405//GO:0016310//GO:0005975//GO:0046486 glycerol-3-phosphate metabolic process//pathogenesis//phosphorylation//carbohydrate metabolic process//glycerolipid metabolic process GO:0016773//GO:0004370 phosphotransferase activity, alcohol group as acceptor//glycerol kinase activity -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.38905 BF_2 112.23 0.82 6004 642915492 XP_008190639.1 842 9.0e-87 PREDICTED: glycerol kinase [Tribolium castaneum]>gi|642915494|ref|XP_008190640.1| PREDICTED: glycerol kinase [Tribolium castaneum]>gi|270003860|gb|EFA00308.1| hypothetical protein TcasGA2_TC003143 [Tribolium castaneum] 572304237 XM_006618025.1 72 2.58419e-26 PREDICTED: Apis dorsata putative glycerol kinase 3-like (LOC102680807), transcript variant X7, mRNA K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q64516 613 1.3e-61 Glycerol kinase OS=Mus musculus GN=Gk PE=2 SV=2 PF02782//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//FGGY family of carbohydrate kinases, N-terminal domain GO:0016310//GO:0046486//GO:0005975//GO:0006072 phosphorylation//glycerolipid metabolic process//carbohydrate metabolic process//glycerol-3-phosphate metabolic process GO:0004370//GO:0016773 glycerol kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.38907 BF_2 151.10 6.06 1330 642912259 XP_008200626.1 559 1.3e-54 PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|642912261|ref|XP_008200627.1| PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|270002461|gb|EEZ98908.1| hypothetical protein TcasGA2_TC004527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92628 208 2.7e-15 Uncharacterized protein KIAA0232 OS=Homo sapiens GN=KIAA0232 PE=1 SV=5 PF12169 DNA polymerase III subunits gamma and tau domain III GO:0006260 DNA replication GO:0003887 DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.38908 BF_2 508.75 2.26 9713 91092856 XP_969290.1 11458 0.0e+00 PREDICTED: protein furry [Tribolium castaneum]>gi|270003079|gb|EEZ99526.1| hypothetical protein TcasGA2_TC000108 [Tribolium castaneum] 751798243 XM_011210726.1 68 7.00878e-24 PREDICTED: Bactrocera dorsalis protein furry-like (LOC105230123), mRNA -- -- -- -- O94915 4766 0.0e+00 Protein furry homolog-like OS=Homo sapiens GN=FRYL PE=1 SV=2 PF09201//PF02140//PF05510 SRX, signal recognition particle receptor alpha subunit//Galactose binding lectin domain//Sarcoglycan alpha/epsilon -- -- GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0016012 sarcoglycan complex KOG1825 Fry-like conserved proteins Cluster-8309.38910 BF_2 1119.49 13.10 3861 546685733 ERL95188.1 972 4.9e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 3.3e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF13639//PF14634 Ring finger domain//zinc-RING finger domain -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.38911 BF_2 68.85 0.76 4054 270007215 EFA03663.1 274 4.5e-21 hypothetical protein TcasGA2_TC013758 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38912 BF_2 543.74 7.87 3178 91084907 XP_969916.1 3665 0.0e+00 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 327 2.39874e-168 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q6GNL7 2853 0.0e+00 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus laevis GN=aldh1l1 PE=2 SV=1 PF02911//PF00551//PF00171 Formyl transferase, C-terminal domain//Formyl transferase//Aldehyde dehydrogenase family GO:0008152//GO:0032259//GO:0055114//GO:0009058 metabolic process//methylation//oxidation-reduction process//biosynthetic process GO:0016491//GO:0008168//GO:0016742//GO:0016620 oxidoreductase activity//methyltransferase activity//hydroxymethyl-, formyl- and related transferase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.38913 BF_2 36.23 0.38 4236 91078850 XP_971848.1 1166 1.7e-124 PREDICTED: uncharacterized protein LOC660531 [Tribolium castaneum]>gi|270004130|gb|EFA00578.1| hypothetical protein TcasGA2_TC003448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03604 DNA directed RNA polymerase, 7 kDa subunit GO:0042318//GO:0006144//GO:0006206//GO:0006351 penicillin biosynthetic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.38914 BF_2 830.44 19.81 2041 642923787 XP_008193883.1 1066 3.3e-113 PREDICTED: uncharacterized protein F13E6.1 [Tribolium castaneum]>gi|642923789|ref|XP_008193884.1| PREDICTED: uncharacterized protein F13E6.1 [Tribolium castaneum]>gi|270006945|gb|EFA03393.1| hypothetical protein TcasGA2_TC013379 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P55326 188 8.7e-13 Uncharacterized protein F13E6.1 OS=Caenorhabditis elegans GN=F13E6.1 PE=3 SV=2 PF10392 Golgi transport complex subunit 5 GO:0006891 intra-Golgi vesicle-mediated transport -- -- GO:0017119 Golgi transport complex KOG4010 Coiled-coil protein TPD52 Cluster-8309.38916 BF_2 337.18 14.47 1262 642936197 XP_008198342.1 1125 2.9e-120 PREDICTED: syntaxin 1A isoform X1 [Tribolium castaneum] 820846578 XM_012485781.1 273 9.77669e-139 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X1, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 999 4.9e-107 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF02601//PF00015//PF04136//PF01499//PF08245//PF09177//PF05739//PF06667//PF00804//PF02346//PF01496//PF04632//PF02485//PF06009 Exonuclease VII, large subunit//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sec34-like family//Herpesvirus UL25 family//Mur ligase middle domain//Syntaxin 6, N-terminal//SNARE domain//Phage shock protein B//Syntaxin//Chordopoxvirus multifunctional envelope protein A27//V-type ATPase 116kDa subunit family//Fusaric acid resistance protein family//Core-2/I-Branching enzyme//Laminin Domain II GO:0009271//GO:0019072//GO:0007165//GO:0006810//GO:0006886//GO:0006355//GO:0009058//GO:0015992//GO:0048193//GO:0019064//GO:0015991//GO:0007155//GO:0006308 phage shock//viral genome packaging//signal transduction//transport//intracellular protein transport//regulation of transcription, DNA-templated//biosynthetic process//proton transport//Golgi vesicle transport//fusion of virus membrane with host plasma membrane//ATP hydrolysis coupled proton transport//cell adhesion//DNA catabolic process GO:0005524//GO:0008375//GO:0015078//GO:0005515//GO:0008855//GO:0004871 ATP binding//acetylglucosaminyltransferase activity//hydrogen ion transmembrane transporter activity//protein binding//exodeoxyribonuclease VII activity//signal transducer activity GO:0042025//GO:0005801//GO:0009318//GO:0005886//GO:0019031//GO:0016020//GO:0033179 host cell nucleus//cis-Golgi network//exodeoxyribonuclease VII complex//plasma membrane//viral envelope//membrane//proton-transporting V-type ATPase, V0 domain KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.38917 BF_2 38.80 1.34 1496 642936197 XP_008198342.1 930 1.4e-97 PREDICTED: syntaxin 1A isoform X1 [Tribolium castaneum] 820846582 XM_012485783.1 230 9.32322e-115 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X3, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 818 5.6e-86 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF00804//PF01496//PF04632//PF02485//PF02601//PF04136//PF01499//PF08245//PF00745//PF09177 Syntaxin//V-type ATPase 116kDa subunit family//Fusaric acid resistance protein family//Core-2/I-Branching enzyme//Exonuclease VII, large subunit//Sec34-like family//Herpesvirus UL25 family//Mur ligase middle domain//Glutamyl-tRNAGlu reductase, dimerisation domain//Syntaxin 6, N-terminal GO:0033014//GO:0048193//GO:0015991//GO:0006308//GO:0006810//GO:0006886//GO:0019072//GO:0015992//GO:0055114//GO:0009058 tetrapyrrole biosynthetic process//Golgi vesicle transport//ATP hydrolysis coupled proton transport//DNA catabolic process//transport//intracellular protein transport//viral genome packaging//proton transport//oxidation-reduction process//biosynthetic process GO:0008855//GO:0050661//GO:0008375//GO:0005524//GO:0008883//GO:0015078 exodeoxyribonuclease VII activity//NADP binding//acetylglucosaminyltransferase activity//ATP binding//glutamyl-tRNA reductase activity//hydrogen ion transmembrane transporter activity GO:0005886//GO:0033179//GO:0016020//GO:0042025//GO:0009318//GO:0005801 plasma membrane//proton-transporting V-type ATPase, V0 domain//membrane//host cell nucleus//exodeoxyribonuclease VII complex//cis-Golgi network KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.38918 BF_2 273.74 1.34 8819 270014238 EFA10686.1 640 3.5e-63 Syntaxin 1A [Tribolium castaneum] 820846584 XM_012485784.1 129 7.83117e-58 PREDICTED: Apis florea syntaxin-1A (LOC100866529), transcript variant X4, mRNA K04560 STX1A syntaxin 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04560 Q24547 565 7.2e-56 Syntaxin-1A OS=Drosophila melanogaster GN=Syx1A PE=1 SV=1 PF04111//PF07851//PF02485//PF05478//PF04632//PF00443//PF00804//PF11744//PF09177//PF05739//PF09003//PF01499//PF04799//PF04136//PF15898 Autophagy protein Apg6//TMPIT-like protein//Core-2/I-Branching enzyme//Prominin//Fusaric acid resistance protein family//Ubiquitin carboxyl-terminal hydrolase//Syntaxin//Aluminium activated malate transporter//Syntaxin 6, N-terminal//SNARE domain//Bacteriophage lambda integrase, N-terminal domain//Herpesvirus UL25 family//fzo-like conserved region//Sec34-like family//cGMP-dependent protein kinase interacting domain GO:0048193//GO:0015743//GO:0015074//GO:0008053//GO:0006886//GO:0006810//GO:0006914//GO:0019072//GO:0016579 Golgi vesicle transport//malate transport//DNA integration//mitochondrial fusion//intracellular protein transport//transport//autophagy//viral genome packaging//protein deubiquitination GO:0005515//GO:0003677//GO:0008907//GO:0008375//GO:0003924//GO:0036459//GO:0019901 protein binding//DNA binding//integrase activity//acetylglucosaminyltransferase activity//GTPase activity//ubiquitinyl hydrolase activity//protein kinase binding GO:0005886//GO:0016020//GO:0005741//GO:0042025//GO:0016021//GO:0005801 plasma membrane//membrane//mitochondrial outer membrane//host cell nucleus//integral component of membrane//cis-Golgi network KOG0810 SNARE protein Syntaxin 1 and related proteins Cluster-8309.38919 BF_2 411.19 4.42 4183 642920663 XP_008192510.1 195 6.6e-12 PREDICTED: tropomyosin-1, isoforms 33/34 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36188 159 4.1e-09 Troponin I OS=Drosophila melanogaster GN=wupA PE=2 SV=3 PF00992//PF00832 Troponin//Ribosomal L39 protein GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840//GO:0005861 intracellular//ribosome//troponin complex -- -- Cluster-8309.38920 BF_2 52.00 2.27 1246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38921 BF_2 1267.63 23.12 2581 270005574 EFA02022.1 1711 6.7e-188 hypothetical protein TcasGA2_TC007647 [Tribolium castaneum] 642919114 XM_008193522.1 141 4.84843e-65 PREDICTED: Tribolium castaneum DDB1- and CUL4-associated factor 8 (LOC656756), mRNA K11804 WDR42A WD repeat-containing protein 42A http://www.genome.jp/dbget-bin/www_bget?ko:K11804 Q5TAQ9 992 6.5e-106 DDB1- and CUL4-associated factor 8 OS=Homo sapiens GN=DCAF8 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1334 WD40 repeat protein Cluster-8309.38923 BF_2 408.00 3.41 5294 607362451 EZA56703.1 148 2.4e-06 hypothetical protein X777_02307, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38924 BF_2 1395.26 20.25 3170 642939241 XP_008194774.1 1673 2.1e-183 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7TSX5 732 1.1e-75 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Rattus norvegicus GN=Sgms1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.38925 BF_2 281.15 2.48 5036 642930595 XP_001807608.2 1912 6.4e-211 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00240//PF03091 Ubiquitin family//CutA1 divalent ion tolerance protein GO:0010038 response to metal ion GO:0005515 protein binding -- -- -- -- Cluster-8309.38928 BF_2 349.03 1.42 10542 270003689 EFA00137.1 2104 7.3e-233 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 305 1.36072e-155 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9BXF3 437 6.0e-41 Cat eye syndrome critical region protein 2 OS=Homo sapiens GN=CECR2 PE=1 SV=2 PF02459//PF00067//PF00631//PF00439 Adenoviral DNA terminal protein//Cytochrome P450//GGL domain//Bromodomain GO:0007165//GO:0055114//GO:0007186//GO:0006260 signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway//DNA replication GO:0005515//GO:0016705//GO:0003677//GO:0020037//GO:0005506//GO:0004871 protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//DNA binding//heme binding//iron ion binding//signal transducer activity GO:0005834 heterotrimeric G-protein complex -- -- Cluster-8309.38930 BF_2 1839.69 7.02 11255 642934739 XP_008197793.1 2939 0.0e+00 PREDICTED: uncharacterized protein LOC658527 [Tribolium castaneum] 462321141 APGK01043373.1 66 1.05113e-22 Dendroctonus ponderosae Seq01043383, whole genome shotgun sequence K11984 SART1, HAF, SNU66 U4/U6.U5 tri-snRNP-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11984 O43290 908 1.5e-95 U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens GN=SART1 PE=1 SV=1 PF00856//PF00569//PF03412//PF07496//PF03343//PF00628//PF01033 SET domain//Zinc finger, ZZ type//Peptidase C39 family//CW-type Zinc Finger//SART-1 family//PHD-finger//Somatomedin B domain GO:0007165//GO:0006955//GO:0006508//GO:0000398 signal transduction//immune response//proteolysis//mRNA splicing, via spliceosome GO:0005044//GO:0005524//GO:0005515//GO:0030247//GO:0008270//GO:0008233 scavenger receptor activity//ATP binding//protein binding//polysaccharide binding//zinc ion binding//peptidase activity GO:0016021 integral component of membrane KOG2217 U4/U6.U5 snRNP associated protein Cluster-8309.38932 BF_2 38.01 0.54 3219 478251374 ENN71840.1 3367 0.0e+00 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 392 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2583 2.6e-290 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain GO:0008152//GO:0055114//GO:0009058 metabolic process//oxidation-reduction process//biosynthetic process GO:0016742//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.38933 BF_2 28.01 0.56 2362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38934 BF_2 540.97 81.14 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38935 BF_2 14.00 1.28 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38937 BF_2 122.74 1.71 3283 91090882 XP_973170.1 768 1.9e-78 PREDICTED: death-associated protein kinase related [Tribolium castaneum] -- -- -- -- -- K08804 STK17 serine/threonine kinase 17 http://www.genome.jp/dbget-bin/www_bget?ko:K08804 Q0KHT7 435 3.2e-41 Death-associated protein kinase related OS=Drosophila melanogaster GN=Drak PE=1 SV=2 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.38938 BF_2 674.55 7.52 4040 642921289 XP_008192802.1 4438 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X2 [Tribolium castaneum] 642921292 XM_008194582.1 488 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X4, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 1.9e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF01763//PF04561//PF06367//PF06371 Herpesvirus UL6 like//RNA polymerase Rpb2, domain 2//Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0016043//GO:0006144//GO:0006351//GO:0030036//GO:0006323//GO:0006206 cellular component organization//purine nucleobase metabolic process//transcription, DNA-templated//actin cytoskeleton organization//DNA packaging//pyrimidine nucleobase metabolic process GO:0003779//GO:0003677//GO:0003899//GO:0017048 actin binding//DNA binding//DNA-directed RNA polymerase activity//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.38939 BF_2 430.91 6.54 3044 642918139 XP_008191383.1 1080 1.2e-114 PREDICTED: hepatic leukemia factor-like, partial [Tribolium castaneum] 642918138 XM_008193161.1 286 1.42177e-145 PREDICTED: Tribolium castaneum hepatic leukemia factor-like (LOC655431), partial mRNA K09057 HLF hepatic leukemia factor http://www.genome.jp/dbget-bin/www_bget?ko:K09057 Q64709 422 9.5e-40 Hepatic leukemia factor OS=Rattus norvegicus GN=Hlf PE=2 SV=1 PF09726//PF03131//PF07716//PF00170 Transmembrane protein//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.38940 BF_2 1453.39 19.31 3435 642924682 XP_008194395.1 1811 2.2e-199 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 612 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1236 4.4e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF00018//PF01424//PF12052//PF08437 SH3 domain//R3H domain//Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal GO:0006816//GO:0009103//GO:0070588 calcium ion transport//lipopolysaccharide biosynthetic process//calcium ion transmembrane transport GO:0003676//GO:0008918//GO:0005245//GO:0005515 nucleic acid binding//lipopolysaccharide 3-alpha-galactosyltransferase activity//voltage-gated calcium channel activity//protein binding GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.38941 BF_2 582.50 12.13 2296 -- -- -- -- -- 642926067 XM_008196530.1 61 1.27585e-20 PREDICTED: Tribolium castaneum calsyntenin-1 (LOC659467), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38943 BF_2 531.00 37.28 883 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08513 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38944 BF_2 904.50 19.07 2271 -- -- -- -- -- 642926067 XM_008196530.1 61 1.26174e-20 PREDICTED: Tribolium castaneum calsyntenin-1 (LOC659467), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38945 BF_2 799.25 8.54 4202 642932431 XP_008197110.1 2076 5.1e-230 PREDICTED: uncharacterized protein LOC100141760 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.38946 BF_2 71.78 0.47 6734 546676860 ERL87797.1 1674 3.4e-183 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.31965e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8NBJ9 1125 6.4e-121 SID1 transmembrane family member 2 OS=Homo sapiens GN=SIDT2 PE=1 SV=2 PF00097//PF01133//PF08030//PF13965//PF00175 Zinc finger, C3HC4 type (RING finger)//Enhancer of rudimentary//Ferric reductase NAD binding domain//dsRNA-gated channel SID-1//Oxidoreductase NAD-binding domain GO:0045747//GO:0006221//GO:0015931//GO:0033227//GO:0055114//GO:0007049 positive regulation of Notch signaling pathway//pyrimidine nucleotide biosynthetic process//nucleobase-containing compound transport//dsRNA transport//oxidation-reduction process//cell cycle GO:0016491//GO:0051033//GO:0046872 oxidoreductase activity//RNA transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.38947 BF_2 1115.51 11.23 4441 91086115 XP_968072.1 1323 1.1e-142 PREDICTED: sister chromatid cohesion protein DCC1 [Tribolium castaneum] -- -- -- -- -- K11271 DSCC1, DCC1 sister chromatid cohesion protein DCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K11271 Q6GMB0 633 4.7e-64 Sister chromatid cohesion protein DCC1 OS=Xenopus laevis GN=dscc1 PE=2 SV=1 PF00018//PF14604//PF04421//PF04088 SH3 domain//Variant SH3 domain//Mss4 protein//Peroxin 13, N-terminal region GO:0007264//GO:0016560//GO:0043087 small GTPase mediated signal transduction//protein import into peroxisome matrix, docking//regulation of GTPase activity GO:0005515//GO:0005085 protein binding//guanyl-nucleotide exchange factor activity GO:0005777//GO:0016021 peroxisome//integral component of membrane KOG3875 Peroxisomal biogenesis protein peroxin Cluster-8309.38949 BF_2 195.00 12.33 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38950 BF_2 554.03 5.10 4834 642914654 XP_008190301.1 1656 3.0e-181 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.87333e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.38951 BF_2 1266.35 14.51 3937 642914454 XP_008201683.1 669 6.8e-67 PREDICTED: proteoglycan 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38953 BF_2 1770.62 21.78 3688 91084663 XP_967750.1 1183 1.6e-126 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 4.49103e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 Q2KHV7 778 6.0e-81 Ubiquitin carboxyl-terminal hydrolase 2 OS=Bos taurus GN=USP2 PE=2 SV=1 PF05427//PF00443//PF15957//PF12422 Acidic fibroblast growth factor binding (FIBP)//Ubiquitin carboxyl-terminal hydrolase//Commissureless//Condensin II non structural maintenance of chromosomes subunit GO:0006508//GO:0007411//GO:0016579 proteolysis//axon guidance//protein deubiquitination GO:0017134//GO:0036459//GO:0008233 fibroblast growth factor binding//ubiquitinyl hydrolase activity//peptidase activity GO:0005634 nucleus -- -- Cluster-8309.38957 BF_2 10755.57 370.97 1500 91083015 XP_974607.1 1130 9.1e-121 PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|642923430|ref|XP_008193741.1| PREDICTED: retinaldehyde-binding protein 1 [Tribolium castaneum]>gi|270007020|gb|EFA03468.1| hypothetical protein TcasGA2_TC013464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RCA6 368 8.5e-34 Clavesin-1 OS=Pongo abelii GN=CLVS1 PE=2 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.38958 BF_2 73.41 3.10 1278 642915807 XP_008200086.1 1678 2.2e-184 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 210 1.0407e-103 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- Q8CGF6 945 9.0e-101 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.38959 BF_2 181.77 6.77 1410 270003147 EEZ99594.1 759 8.9e-78 hypothetical protein TcasGA2_TC001581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38962 BF_2 236.50 2.71 3936 642927864 XP_008195430.1 2738 8.3e-307 PREDICTED: inhibitor of Bruton tyrosine kinase [Tribolium castaneum]>gi|270010253|gb|EFA06701.1| hypothetical protein TcasGA2_TC009632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPR6 1277 8.8e-139 Inhibitor of Bruton tyrosine kinase OS=Mus musculus GN=Ibtk PE=1 SV=3 PF13606//PF05224//PF00023//PF00651 Ankyrin repeat//NDT80 / PhoG like DNA-binding family//Ankyrin repeat//BTB/POZ domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0783 Uncharacterized conserved protein, contains ankyrin and BTB/POZ domains Cluster-8309.38964 BF_2 233.59 1.96 5263 546672885 ERL84608.1 3095 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1548 4.4e-170 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00573//PF00106//PF00107 Ribosomal protein L4/L1 family//short chain dehydrogenase//Zinc-binding dehydrogenase GO:0042254//GO:0055114//GO:0006412//GO:0008152 ribosome biogenesis//oxidation-reduction process//translation//metabolic process GO:0016491//GO:0003735 oxidoreductase activity//structural constituent of ribosome GO:0005840 ribosome KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.38965 BF_2 3983.97 35.05 5042 91084663 XP_967750.1 2228 1.5e-247 PREDICTED: ubiquitin carboxyl-terminal hydrolase 4 isoform X1 [Tribolium castaneum]>gi|270008628|gb|EFA05076.1| hypothetical protein TcasGA2_TC015173 [Tribolium castaneum] 698430595 XM_009698856.1 46 6.15611e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K11833 USP2_21 ubiquitin carboxyl-terminal hydrolase 2/21 http://www.genome.jp/dbget-bin/www_bget?ko:K11833 O57429 1001 1.1e-106 Ubiquitin carboxyl-terminal hydrolase 2 OS=Gallus gallus GN=USP2 PE=2 SV=1 PF00443//PF05427//PF12422 Ubiquitin carboxyl-terminal hydrolase//Acidic fibroblast growth factor binding (FIBP)//Condensin II non structural maintenance of chromosomes subunit GO:0016579 protein deubiquitination GO:0016787//GO:0017134//GO:0036459 hydrolase activity//fibroblast growth factor binding//ubiquitinyl hydrolase activity GO:0005634 nucleus -- -- Cluster-8309.38966 BF_2 36.00 2.42 910 -- -- -- -- -- 642939846 XM_008195582.1 87 1.74108e-35 PREDICTED: Tribolium castaneum pupal cuticle protein G1A-like (LOC103312114), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.38967 BF_2 2570.00 337.15 606 91081977 XP_968285.1 557 1.0e-54 PREDICTED: ATP synthase subunit delta, mitochondrial [Tribolium castaneum]>gi|270008191|gb|EFA04639.1| hypothetical protein TcasGA2_TC013931 [Tribolium castaneum] -- -- -- -- -- K02134 ATPeF1D, ATP5D, ATP16 F-type H+-transporting ATPase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K02134 Q9D3D9 339 8.0e-31 ATP synthase subunit delta, mitochondrial OS=Mus musculus GN=Atp5d PE=1 SV=1 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1758 Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 Cluster-8309.3897 BF_2 21.61 0.39 2635 91083969 XP_975121.1 1464 3.0e-159 PREDICTED: allatostatin-A receptor [Tribolium castaneum]>gi|270008249|gb|EFA04697.1| hypothetical protein TcasGA2_TC014731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P83858 353 8.2e-32 Pyroglutamylated RFamide peptide receptor OS=Rattus norvegicus GN=Qrfpr PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007268//GO:0007186//GO:0007187 synaptic transmission//G-protein coupled receptor signaling pathway//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004983//GO:0004930 neuropeptide Y receptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.38971 BF_2 1667.72 8.41 8579 642923487 XP_008193531.1 372 4.1e-32 PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Tribolium castaneum] 642923486 XM_008195309.1 339 1.39135e-174 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA K14946 RBFOX, FOX RNA binding protein fox-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14946 Q9NWB1 148 1.6e-07 RNA binding protein fox-1 homolog 1 OS=Homo sapiens GN=RBFOX1 PE=1 SV=2 PF00076//PF04117 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Mpv17 / PMP22 family -- -- GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.38972 BF_2 86.69 0.49 7677 642912688 XP_008200962.1 1566 1.3e-170 PREDICTED: ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial isoform X1 [Tribolium castaneum]>gi|270002375|gb|EEZ98822.1| hypothetical protein TcasGA2_TC004428 [Tribolium castaneum] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1223 3.1e-132 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF00437//PF07724//PF14532//PF05496//PF06068//PF00270//PF01096//PF10662//PF00005//PF04851//PF00004//PF01695//PF07728//PF01057//PF00158//PF00503//PF02562//PF02367 Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//DEAD/DEAH box helicase//Transcription factor S-II (TFIIS)//Ethanolamine utilisation - propanediol utilisation//ABC transporter//Type III restriction enzyme, res subunit//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Sigma-54 interaction domain//G-protein alpha subunit//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006457//GO:0006351//GO:0006576//GO:0006310//GO:0002949//GO:0006281//GO:0006810//GO:0019079//GO:0007165//GO:0007186//GO:0006355 protein folding//transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification//DNA repair//transport//viral genome replication//signal transduction//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated GO:0003677//GO:0003678//GO:0017111//GO:0009378//GO:0004871//GO:0003676//GO:0003924//GO:0008134//GO:0016787//GO:0031683//GO:0005524//GO:0016887//GO:0019001//GO:0051082//GO:0008270 DNA binding//DNA helicase activity//nucleoside-triphosphatase activity//four-way junction helicase activity//signal transducer activity//nucleic acid binding//GTPase activity//transcription factor binding//hydrolase activity//G-protein beta/gamma-subunit complex binding//ATP binding//ATPase activity//guanyl nucleotide binding//unfolded protein binding//zinc ion binding GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.38975 BF_2 2854.96 23.34 5404 642932918 XP_008197187.1 5621 0.0e+00 PREDICTED: uncharacterized protein LOC656619 [Tribolium castaneum] 642932917 XM_008198965.1 278 7.10458e-141 PREDICTED: Tribolium castaneum uncharacterized LOC656619 (LOC656619), mRNA K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q3UQ28 971 3.7e-103 Peroxidasin homolog OS=Mus musculus GN=Pxdn PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.38978 BF_2 2904.75 63.99 2186 270014320 EFA10768.1 2315 5.2e-258 dunce [Tribolium castaneum] 642935593 XM_008199853.1 759 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X15, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 1813 3.4e-201 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.38979 BF_2 22.07 0.40 2573 195490337 XP_002093097.1 297 6.1e-24 GE21136 [Drosophila yakuba]>gi|194179198|gb|EDW92809.1| GE21136 [Drosophila yakuba] -- -- -- -- -- -- -- -- -- P82596 195 1.7e-13 Perlucin OS=Haliotis laevigata PE=1 SV=3 PF07740//PF02944 Ion channel inhibitory toxin//BESS motif GO:0006810//GO:0009405 transport//pathogenesis GO:0008200//GO:0003677 ion channel inhibitor activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.38980 BF_2 1754.67 18.04 4356 270008438 EFA04886.1 1526 3.2e-166 hypothetical protein TcasGA2_TC014948 [Tribolium castaneum] 817062635 XM_012397559.1 107 6.54013e-46 PREDICTED: Athalia rosae arginine-glutamic acid dipeptide repeats protein (LOC105684303), transcript variant X4, mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q9P2R6 679 2.1e-69 Arginine-glutamic acid dipeptide repeats protein OS=Homo sapiens GN=RERE PE=1 SV=2 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.38981 BF_2 456.28 13.95 1655 91095219 XP_969883.1 687 2.3e-69 PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940081|ref|XP_008192927.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|642940083|ref|XP_008192931.1| PREDICTED: peptidoglycan-recognition protein 2 [Tribolium castaneum]>gi|270016019|gb|EFA12467.1| hypothetical protein TcasGA2_TC010611 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q765P3 534 5.3e-53 Peptidoglycan-recognition protein 2 OS=Holotrichia diomphalia GN=PGRP-2 PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0009253//GO:0006807 peptidoglycan biosynthetic process//peptidoglycan catabolic process//nitrogen compound metabolic process GO:0008270//GO:0008745 zinc ion binding//N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.38982 BF_2 24.46 0.43 2689 642912272 XP_008200632.1 704 4.1e-71 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 6.7e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF15965//PF01414//PF00089 TRAF-like zinc-finger//Delta serrate ligand//Trypsin GO:0006508//GO:0007154 proteolysis//cell communication GO:0008270//GO:0004252 zinc ion binding//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.38983 BF_2 439.49 1.72 10967 642940144 XP_008200104.1 3309 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H269 1673 3.0e-184 Vacuolar protein sorting-associated protein 16 homolog OS=Homo sapiens GN=VPS16 PE=1 SV=2 PF04841//PF04840 Vps16, N-terminal region//Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.38984 BF_2 865.84 26.35 1662 282158103 NP_001164095.1 1660 3.5e-182 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.8127e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1365 2.3e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF04851//PF03141 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Putative S-adenosyl-L-methionine-dependent methyltransferase -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0008168 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//methyltransferase activity -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.38985 BF_2 225.79 1.10 8869 646710408 KDR15927.1 1192 3.5e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.71491e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 PF11561 Single strand annealing-weakened 1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends GO:0070336 flap-structured DNA binding -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.38986 BF_2 65.81 2.41 1430 669274418 XP_008629343.1 357 3.7e-31 PREDICTED: polyubiquitin-B isoform X7 [Corvus brachyrhynchos] 69608590 AM040016.1 261 5.20816e-132 Timarcha balearica mRNA for ubiquitin/ribosomal protein S27Ae fusion protein (ubq/S27Ae gene) K02977 RP-S27Ae, RPS27A small subunit ribosomal protein S27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02977 P0CG60 351 7.6e-32 Polyubiquitin-B OS=Pongo pygmaeus GN=UBB PE=3 SV=1 PF06305//PF00240//PF14560//PF01599 Protein of unknown function (DUF1049)//Ubiquitin family//Ubiquitin-like domain//Ribosomal protein S27a GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005887//GO:0005840 integral component of plasma membrane//ribosome KOG0004 Ubiquitin/40S ribosomal protein S27a fusion Cluster-8309.38988 BF_2 732.21 3.87 8209 270001102 EEZ97549.1 1832 2.0e-201 hypothetical protein TcasGA2_TC011399 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZW4 179 3.8e-11 Dentin sialophosphoprotein OS=Homo sapiens GN=DSPP PE=1 SV=2 PF03931//PF04433 Skp1 family, tetramerisation domain//SWIRM domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.38990 BF_2 127.43 1.62 3576 642936594 XP_008198499.1 1421 3.9e-154 PREDICTED: solute carrier family 2, facilitated glucose transporter member 1-like isoform X2 [Tribolium castaneum]>gi|270014149|gb|EFA10597.1| hypothetical protein TcasGA2_TC012857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13355 670 1.9e-68 Solute carrier family 2, facilitated glucose transporter member 1 OS=Oryctolagus cuniculus GN=SLC2A1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.38991 BF_2 1256.83 32.97 1882 170321837 BAG14263.1 925 6.7e-97 GNBP1 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- O96363 566 1.2e-56 Beta-1,3-glucan-binding protein (Fragment) OS=Hyphantria cunea GN=gnbp1 PE=2 SV=1 PF15886//PF00722//PF10584 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16//Proteasome subunit A N-terminal signature GO:0005975//GO:0006511 carbohydrate metabolic process//ubiquitin-dependent protein catabolic process GO:0004175//GO:0004553//GO:0030246 endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding GO:0019773 proteasome core complex, alpha-subunit complex -- -- Cluster-8309.38995 BF_2 6213.88 61.28 4529 642928001 XP_008195479.1 1414 3.2e-153 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] 642928002 XM_008197258.1 75 4.18158e-28 PREDICTED: Tribolium castaneum UDP-glucuronosyltransferase 2B31-like (LOC663770), mRNA K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 Q9Y4C0 532 2.5e-52 Neurexin-3 OS=Homo sapiens GN=NRXN3 PE=1 SV=4 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.38996 BF_2 580.53 7.72 3434 642921494 XP_968130.3 2423 2.4e-270 PREDICTED: uncharacterized protein LOC656511 [Tribolium castaneum]>gi|270006226|gb|EFA02674.1| hypothetical protein TcasGA2_TC008395 [Tribolium castaneum] 642921493 XM_963037.3 221 2.18311e-109 PREDICTED: Tribolium castaneum uncharacterized LOC656511 (LOC656511), mRNA -- -- -- -- O43182 480 2.0e-46 Rho GTPase-activating protein 6 OS=Homo sapiens GN=ARHGAP6 PE=1 SV=3 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG2710 Rho GTPase-activating protein Cluster-8309.38997 BF_2 828.19 15.14 2575 571330970 AHF27417.1 1710 8.7e-188 putative sugar transporter 4_1 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.45371e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 942 4.0e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF00083//PF08157//PF07690 Sugar (and other) transporter//NUC129 domain//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0569 Permease of the major facilitator superfamily Cluster-8309.39 BF_2 94.79 3.25 1508 815896315 XP_012246840.1 705 1.7e-71 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- Q9WUW9 404 5.7e-38 Sulfotransferase 1C2A OS=Rattus norvegicus GN=Sult1c2a PE=2 SV=2 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.39001 BF_2 209.52 1.18 7688 642918353 XP_008199964.1 4772 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1PBJ0 2374 1.1e-265 Rap guanine nucleotide exchange factor 2 OS=Canis familiaris GN=RAPGEF2 PE=1 SV=2 PF13180//PF00617//PF00595//PF00788 PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF)//Ras association (RalGDS/AF-6) domain GO:0007165//GO:0043087//GO:0007264 signal transduction//regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.39002 BF_2 23.60 0.41 2686 478257818 ENN77961.1 729 5.1e-74 hypothetical protein YQE_05638, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39003 BF_2 227.96 1.51 6620 642931206 XP_008196483.1 165 3.2e-08 PREDICTED: WD repeat domain phosphoinositide-interacting protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39004 BF_2 67.92 0.67 4520 642927083 XP_008195130.1 5359 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927082 XM_008196908.1 520 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X1, mRNA -- -- -- -- Q9ULI1 411 2.7e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF00005//PF07728//PF03193//PF01637//PF00004//PF00910//PF00931 ABC transporter//AAA domain (dynein-related subfamily)//Protein of unknown function, DUF258//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//RNA helicase//NB-ARC domain -- -- GO:0043531//GO:0003924//GO:0003724//GO:0005525//GO:0005524//GO:0003723//GO:0016887 ADP binding//GTPase activity//RNA helicase activity//GTP binding//ATP binding//RNA binding//ATPase activity -- -- -- -- Cluster-8309.39005 BF_2 279.05 3.19 3943 189241935 XP_969741.2 2165 2.3e-240 PREDICTED: coronin-2B-like isoform X2 [Tribolium castaneum] 612001587 XM_007485717.1 39 3.74057e-08 PREDICTED: Monodelphis domestica coronin 6 (CORO6), transcript variant X3, mRNA K13887 CORO2 coronin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13887 A8WGE3 1310 1.3e-142 Coronin-2B OS=Xenopus tropicalis GN=coro2b PE=2 SV=1 PF04977//PF00400 Septum formation initiator//WD domain, G-beta repeat GO:0007049 cell cycle GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.39006 BF_2 349.00 3.05 5072 189236774 XP_001807993.1 1012 1.5e-106 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 2 [Tribolium castaneum]>gi|270006213|gb|EFA02661.1| hypothetical protein TcasGA2_TC008382 [Tribolium castaneum] -- -- -- -- -- K15425 PPP4R2 serine/threonine-protein phosphatase 4 regulatory subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15425 Q9W2U4 502 8.4e-49 Serine/threonine-protein phosphatase 4 regulatory subunit 2 OS=Drosophila melanogaster GN=PPP4R2r PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3175 Protein phosphatase 4 regulatory subunit 2 related protein Cluster-8309.39007 BF_2 351.84 1.60 9482 91092856 XP_969290.1 11440 0.0e+00 PREDICTED: protein furry [Tribolium castaneum]>gi|270003079|gb|EEZ99526.1| hypothetical protein TcasGA2_TC000108 [Tribolium castaneum] 751798243 XM_011210726.1 68 6.84146e-24 PREDICTED: Bactrocera dorsalis protein furry-like (LOC105230123), mRNA -- -- -- -- O94915 4766 0.0e+00 Protein furry homolog-like OS=Homo sapiens GN=FRYL PE=1 SV=2 PF02140//PF05510 Galactose binding lectin domain//Sarcoglycan alpha/epsilon -- -- GO:0030246 carbohydrate binding GO:0016012 sarcoglycan complex KOG1825 Fry-like conserved proteins Cluster-8309.39009 BF_2 758.26 7.82 4342 642928504 XP_008193818.1 3415 0.0e+00 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGW4 1340 4.8e-146 Endoplasmic reticulum metallopeptidase 1 OS=Xenopus laevis GN=ermp1 PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.39010 BF_2 1673.35 29.33 2674 642935588 XP_008198072.1 3009 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform M isoform X10 [Tribolium castaneum] 642935587 XM_008199850.1 976 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X12, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 2360 1.6e-264 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF07469//PF00233//PF00104 Domain of unknown function (DUF1518)//3'5'-cyclic nucleotide phosphodiesterase//Ligand-binding domain of nuclear hormone receptor GO:0006144//GO:0007165//GO:0043401//GO:0006355 purine nucleobase metabolic process//signal transduction//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.39011 BF_2 943.03 7.55 5511 642916459 XP_008191036.1 2630 3.9e-294 PREDICTED: sestrin homolog [Tribolium castaneum]>gi|642916461|ref|XP_008191037.1| PREDICTED: sestrin homolog [Tribolium castaneum] 642916460 XM_008192815.1 596 0 PREDICTED: Tribolium castaneum sestrin homolog (LOC664359), transcript variant X2, mRNA K10141 SESN sestrin http://www.genome.jp/dbget-bin/www_bget?ko:K10141 P58006 1113 1.3e-119 Sestrin-1 OS=Mus musculus GN=Sesn1 PE=2 SV=3 PF04636 PA26 p53-induced protein (sestrin) GO:1901031 regulation of response to reactive oxygen species -- -- GO:0005634 nucleus KOG3746 Uncharacterized conserved protein Cluster-8309.39012 BF_2 189.08 1.94 4361 270001801 EEZ98248.1 1246 9.3e-134 hypothetical protein TcasGA2_TC000687 [Tribolium castaneum] 817087970 XM_012411364.1 68 3.13378e-24 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q8BGK6 733 1.2e-75 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF13520//PF01990//PF01424//PF00324 Amino acid permease//ATP synthase (F/14-kDa) subunit//R3H domain//Amino acid permease GO:0003333//GO:0055085//GO:0006865//GO:0006810//GO:0034220 amino acid transmembrane transport//transmembrane transport//amino acid transport//transport//ion transmembrane transport GO:0003676//GO:0015171 nucleic acid binding//amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.39013 BF_2 272.80 2.83 4326 642919644 XP_008192004.1 1576 5.0e-172 PREDICTED: fatty acid hydroxylase domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 Q9GKT2 894 2.5e-94 Fatty acid hydroxylase domain-containing protein 2 OS=Macaca fascicularis GN=FAXDC2 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0055114//GO:0006633 oxidation-reduction process//fatty acid biosynthetic process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- KOG0873 C-4 sterol methyl oxidase Cluster-8309.39014 BF_2 1020.22 11.12 4126 91080745 XP_966455.1 1586 3.3e-173 PREDICTED: fatty acid hydroxylase domain-containing protein 2 isoform X1 [Tribolium castaneum]>gi|270005453|gb|EFA01901.1| hypothetical protein TcasGA2_TC007511 [Tribolium castaneum] -- -- -- -- -- K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 Q9GKT2 894 2.4e-94 Fatty acid hydroxylase domain-containing protein 2 OS=Macaca fascicularis GN=FAXDC2 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity GO:0016021 integral component of membrane KOG0873 C-4 sterol methyl oxidase Cluster-8309.39015 BF_2 291.18 3.55 3714 642919644 XP_008192004.1 1576 4.3e-172 PREDICTED: fatty acid hydroxylase domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K07750 E1.14.13.72, SC4MOL, ERG25 methylsterol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K07750 Q9GKT2 894 2.1e-94 Fatty acid hydroxylase domain-containing protein 2 OS=Macaca fascicularis GN=FAXDC2 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0006633//GO:0055114 fatty acid biosynthetic process//oxidation-reduction process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity -- -- KOG0873 C-4 sterol methyl oxidase Cluster-8309.39016 BF_2 221.37 2.01 4901 24646906 NP_731941.1 804 1.9e-82 effete, isoform A [Drosophila melanogaster]>gi|187117170|ref|NP_001119686.1| effete [Acyrthosiphon pisum]>gi|442619106|ref|NP_001262578.1| effete, isoform B [Drosophila melanogaster]>gi|442619108|ref|NP_001262579.1| effete, isoform C [Drosophila melanogaster]>gi|58381090|ref|XP_310998.2| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|91077526|ref|XP_970430.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Tribolium castaneum]>gi|156550189|ref|XP_001605481.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Nasonia vitripennis]>gi|157134117|ref|XP_001663154.1| AAEL003103-PA [Aedes aegypti]>gi|194743322|ref|XP_001954149.1| GF18131 [Drosophila ananassae]>gi|194900836|ref|XP_001979961.1| GG21088 [Drosophila erecta]>gi|195061220|ref|XP_001995948.1| GH14086 [Drosophila grimshawi]>gi|195113175|ref|XP_002001144.1| GI10619 [Drosophila mojavensis]>gi|195143851|ref|XP_002012910.1| GL23670 [Drosophila persimilis]>gi|195328929|ref|XP_002031164.1| GM25828 [Drosophila sechellia]>gi|195390905|ref|XP_002054107.1| GJ22971 [Drosophila virilis]>gi|195444200|ref|XP_002069759.1| GK11688 [Drosophila willistoni]>gi|195501528|ref|XP_002097834.1| eff [Drosophila yakuba]>gi|195570846|ref|XP_002103415.1| GD20402 [Drosophila simulans]>gi|198451027|ref|XP_002137205.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|498939690|ref|XP_004521259.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|498939696|ref|XP_004521261.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratitis capitata]>gi|557775059|ref|XP_005187176.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Musca domestica]>gi|746860060|ref|XP_011060857.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Acromyrmex echinatior]>gi|749733753|ref|XP_011147642.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Harpegnathos saltator]>gi|751469127|ref|XP_011189731.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera cucurbitae]>gi|751776279|ref|XP_011214825.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|751776281|ref|XP_011214826.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Bactrocera dorsalis]>gi|755991226|ref|XP_011312803.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Fopius arisanus]>gi|759038025|ref|XP_011351525.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Cerapachys biroi]>gi|766937511|ref|XP_011501212.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Ceratosolen solmsi marchali]>gi|769846059|ref|XP_011634316.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Pogonomyrmex barbatus]>gi|780635308|ref|XP_011686505.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa isoform X2 [Wasmannia auropunctata]>gi|795091706|ref|XP_011879556.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Vollenhovia emeryi]>gi|801395562|ref|XP_012058392.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Atta cephalotes]>gi|815791114|ref|XP_012216125.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Linepithema humile]>gi|817074138|ref|XP_012259245.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Athalia rosae]>gi|817201924|ref|XP_012276729.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Orussus abietinus]>gi|826426802|ref|XP_012527496.1| PREDICTED: ubiquitin-conjugating enzyme E2-17 kDa [Monomorium pharaonis]>gi|136643|sp|P25867.1|UBCD1_DROME RecName: Full=Ubiquitin-conjugating enzyme E2-17 kDa; AltName: Full=Protein effete; AltName: Full=Ubiquitin carrier protein; AltName: Full=Ubiquitin-protein ligase>gi|8783|emb|CAA44453.1| ubiquitin-conjugating enzyme [Drosophila melanogaster]>gi|7299919|gb|AAF55093.1| effete, isoform A [Drosophila melanogaster]>gi|16648156|gb|AAL25343.1| GH14739p [Drosophila melanogaster]>gi|46561756|gb|AAT01083.1| putative ubiquitin-conjugating enzyme [Homalodisca vitripennis]>gi|55243675|gb|EAA06420.3| AGAP000145-PA [Anopheles gambiae str. PEST]>gi|89473748|gb|ABD72686.1| putative ubiquitin-conjugating enzyme [Acyrthosiphon pisum]>gi|94468952|gb|ABF18325.1| ubiquitin-conjugating enzyme [Aedes aegypti]>gi|108881406|gb|EAT45631.1| AAEL003103-PA [Aedes aegypti]>gi|190627186|gb|EDV42710.1| GF18131 [Drosophila ananassae]>gi|190651664|gb|EDV48919.1| GG21088 [Drosophila erecta]>gi|193891740|gb|EDV90606.1| GH14086 [Drosophila grimshawi]>gi|193917738|gb|EDW16605.1| GI10619 [Drosophila mojavensis]>gi|194101853|gb|EDW23896.1| GL23670 [Drosophila persimilis]>gi|194120107|gb|EDW42150.1| GM25828 [Drosophila sechellia]>gi|194152193|gb|EDW67627.1| GJ22971 [Drosophila virilis]>gi|194165844|gb|EDW80745.1| GK11688 [Drosophila willistoni]>gi|194183935|gb|EDW97546.1| eff [Drosophila yakuba]>gi|194199342|gb|EDX12918.1| GD20402 [Drosophila simulans]>gi|198131302|gb|EDY67763.1| GA26693 [Drosophila pseudoobscura pseudoobscura]>gi|220945198|gb|ACL85142.1| eff-PA, partial [synthetic construct]>gi|220955014|gb|ACL90050.1| eff-PA [synthetic construct]>gi|239791033|dbj|BAH72034.1| ACYPI000078 [Acyrthosiphon pisum]>gi|270002752|gb|EEZ99199.1| effete [Tribolium castaneum]>gi|332375666|gb|AEE62974.1| unknown [Dendroctonus ponderosae]>gi|440217433|gb|AGB95959.1| effete, isoform B [Drosophila melanogaster]>gi|440217434|gb|AGB95960.1| effete, isoform C [Drosophila melanogaster]>gi|478262539|gb|ENN81177.1| hypothetical protein YQE_02422, partial [Dendroctonus ponderosae]>gi|546683237|gb|ERL93069.1| hypothetical protein D910_10371 [Dendroctonus ponderosae]>gi|646714335|gb|KDR18345.1| Ubiquitin-conjugating enzyme E2-17 kDa [Zootermopsis nevadensis]>gi|861642908|gb|KMQ94120.1| ubiquitin-conjugating enzyme [Lasius niger]>gi|900914055|gb|KMZ03557.1| uncharacterized protein Dsimw501_GD20402 [Drosophila simulans] 642914089 XM_965337.3 556 0 PREDICTED: Tribolium castaneum effete (LOC658996), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P25867 804 7.7e-84 Ubiquitin-conjugating enzyme E2-17 kDa OS=Drosophila melanogaster GN=eff PE=2 SV=1 PF05773//PF05743 RWD domain//UEV domain GO:0016567//GO:0051276//GO:0007286//GO:0031647//GO:0008054//GO:0007140//GO:0030718//GO:0006464//GO:0045676//GO:0048132//GO:0016322//GO:0015031//GO:0007067 protein ubiquitination//chromosome organization//spermatid development//regulation of protein stability//negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation//male meiosis//germ-line stem cell population maintenance//cellular protein modification process//regulation of R7 cell differentiation//female germ-line stem cell asymmetric division//neuron remodeling//protein transport//mitotic nuclear division GO:0004842//GO:0005515//GO:0005524 ubiquitin-protein transferase activity//protein binding//ATP binding GO:0005875 microtubule associated complex KOG0417 Ubiquitin-protein ligase Cluster-8309.39017 BF_2 758.92 7.29 4645 642926413 XP_008191952.1 2922 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X1 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.37768e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 3.5e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39018 BF_2 188.75 2.25 3801 572098878 AHF48760.1 2137 3.9e-237 mitochondrial arginyl-tRNA synthetase [Caryedes brasiliensis] 874501526 XM_013108851.1 55 4.59736e-17 PREDICTED: Anas platyrhynchos mitochondrial ribosomal protein S9 (MRPS9), mRNA K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 Q0P5H7 923 9.5e-98 Probable arginine--tRNA ligase, mitochondrial OS=Bos taurus GN=RARS2 PE=2 SV=1 PF00380//PF02572//PF00750//PF05746 Ribosomal protein S9/S16//ATP:corrinoid adenosyltransferase BtuR/CobO/CobP//tRNA synthetases class I (R)//DALR anticodon binding domain GO:0006420//GO:0042254//GO:0009236//GO:0006525//GO:0015994//GO:0006412//GO:0006560 arginyl-tRNA aminoacylation//ribosome biogenesis//cobalamin biosynthetic process//arginine metabolic process//chlorophyll metabolic process//translation//proline metabolic process GO:0003735//GO:0005524//GO:0008817//GO:0004814 structural constituent of ribosome//ATP binding//cob(I)yrinic acid a,c-diamide adenosyltransferase activity//arginine-tRNA ligase activity GO:0005840 ribosome KOG1195 Arginyl-tRNA synthetase Cluster-8309.39019 BF_2 25.00 0.50 2369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39020 BF_2 91.35 5.64 965 478252801 ENN73192.1 581 2.7e-57 hypothetical protein YQE_10171, partial [Dendroctonus ponderosae] 462301115 APGK01050708.1 87 1.85039e-35 Dendroctonus ponderosae Seq01050718, whole genome shotgun sequence -- -- -- -- Q969T9 333 6.3e-30 WW domain-binding protein 2 OS=Homo sapiens GN=WBP2 PE=1 SV=1 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0043130//GO:0032266 ubiquitin binding//phosphatidylinositol-3-phosphate binding -- -- KOG3294 WW domain binding protein WBP-2, contains GRAM domain Cluster-8309.39021 BF_2 47.99 2.24 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04926 Poly(A) polymerase predicted RNA binding domain GO:0043631 RNA polyadenylation GO:0003723 RNA binding -- -- -- -- Cluster-8309.39022 BF_2 5774.55 64.45 4035 642922298 XP_008193099.1 1327 3.5e-143 PREDICTED: PDZ and LIM domain protein 3 isoform X5 [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1016 1.7e-108 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF02771//PF00441//PF02770//PF02270//PF00595//PF13180//PF04179 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Transcription initiation factor IIF, beta subunit//PDZ domain (Also known as DHR or GLGF)//PDZ domain//Initiator tRNA phosphoribosyl transferase GO:0055114//GO:0006367//GO:0006118//GO:0019988//GO:0006366//GO:0008152 oxidation-reduction process//transcription initiation from RNA polymerase II promoter//obsolete electron transport//charged-tRNA amino acid modification//transcription from RNA polymerase II promoter//metabolic process GO:0016627//GO:0050660//GO:0005515//GO:0003995//GO:0043399 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//protein binding//acyl-CoA dehydrogenase activity//tRNA A64-2'-O-ribosylphosphate transferase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.39023 BF_2 470.62 4.58 4584 642922300 XP_008193101.1 1696 6.5e-186 PREDICTED: LOW QUALITY PROTEIN: isovaleryl-CoA dehydrogenase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1323 4.8e-144 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF04179//PF13180//PF00595//PF02770//PF02270//PF02771//PF00441 Initiator tRNA phosphoribosyl transferase//PDZ domain//PDZ domain (Also known as DHR or GLGF)//Acyl-CoA dehydrogenase, middle domain//Transcription initiation factor IIF, beta subunit//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006367//GO:0055114//GO:0006118//GO:0006366//GO:0019988//GO:0008152 transcription initiation from RNA polymerase II promoter//oxidation-reduction process//obsolete electron transport//transcription from RNA polymerase II promoter//charged-tRNA amino acid modification//metabolic process GO:0016627//GO:0050660//GO:0005515//GO:0043399//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//protein binding//tRNA A64-2'-O-ribosylphosphate transferase activity//acyl-CoA dehydrogenase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.39025 BF_2 510.55 2.72 8130 91077082 XP_969760.1 2971 0.0e+00 PREDICTED: protein NRDE2 homolog [Tribolium castaneum]>gi|270002034|gb|EEZ98481.1| hypothetical protein TcasGA2_TC000974 [Tribolium castaneum] 742984403 CP010377.1 47 2.76625e-12 Enterobacter cloacae strain 34983, complete genome K03639 MOCS1, moaA cyclic pyranopterin phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K03639 Q8IQF1 1535 2.2e-168 Molybdenum cofactor biosynthesis protein 1 OS=Drosophila melanogaster GN=Mocs1 PE=2 SV=1 PF05373//PF04055//PF00057//PF15015//PF06463//PF01967 L-proline 3-hydroxylase, C-terminal//Radical SAM superfamily//Low-density lipoprotein receptor domain class A//Spermatogenesis-associated, N-terminal//Molybdenum Cofactor Synthesis C//MoaC family GO:0006777//GO:0055114//GO:0007283 Mo-molybdopterin cofactor biosynthetic process//oxidation-reduction process//spermatogenesis GO:0003824//GO:0005515//GO:0016706//GO:0051536//GO:0051539 catalytic activity//protein binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//iron-sulfur cluster binding//4 iron, 4 sulfur cluster binding GO:0005794//GO:0019008 Golgi apparatus//molybdopterin synthase complex KOG2876 Molybdenum cofactor biosynthesis pathway protein Cluster-8309.39026 BF_2 363.26 6.19 2744 91086797 XP_973406.1 1680 2.8e-184 PREDICTED: CTD small phosphatase-like protein 2 [Tribolium castaneum]>gi|270009707|gb|EFA06155.1| hypothetical protein TcasGA2_TC009000 [Tribolium castaneum] 642929007 XM_008197430.1 42 5.57252e-10 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 8 (LOC662164), mRNA K17616 CTDSPL2 CTD small phosphatase-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17616 Q66KM5 893 2.1e-94 CTD small phosphatase-like protein 2 OS=Xenopus tropicalis GN=ctdspl2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.39030 BF_2 157.84 1.57 4488 189237458 XP_967667.2 1462 8.6e-159 PREDICTED: solute carrier family 35 member E2-like [Tribolium castaneum] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 857 5.1e-90 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.39031 BF_2 190.00 2.17 3944 270013544 EFA09992.1 697 3.9e-70 hypothetical protein TcasGA2_TC012159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3ZY60 238 2.7e-18 Pleckstrin homology domain-containing family A member 8 OS=Rattus norvegicus GN=Plekha8 PE=1 SV=1 PF08718 Glycolipid transfer protein (GLTP) GO:0046836 glycolipid transport GO:0051861//GO:0017089 glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG3221 Glycolipid transfer protein Cluster-8309.39032 BF_2 2164.00 15.93 5969 478263046 ENN81446.1 3102 0.0e+00 hypothetical protein YQE_02139, partial [Dendroctonus ponderosae] -- -- -- -- -- K14297 NUP98, ADAR2, NUP116 nuclear pore complex protein Nup98-Nup96 http://www.genome.jp/dbget-bin/www_bget?ko:K14297 P52948 679 2.9e-69 Nuclear pore complex protein Nup98-Nup96 OS=Homo sapiens GN=NUP98 PE=1 SV=4 PF06455//PF04096 NADH dehydrogenase subunit 5 C-terminus//Nucleoporin autopeptidase GO:0055114//GO:0015992//GO:0006744//GO:0006814//GO:0006810//GO:0006120//GO:0042773 oxidation-reduction process//proton transport//ubiquinone biosynthetic process//sodium ion transport//transport//mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled electron transport GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005643 nuclear pore KOG0845 Nuclear pore complex, Nup98 component (sc Nup145/Nup100/Nup116) Cluster-8309.39033 BF_2 351.31 1.19 12633 642914032 XP_008201515.1 5554 0.0e+00 PREDICTED: syntaxin-binding protein 5 isoform X2 [Tribolium castaneum] 751777385 XM_011199394.1 86 8.99569e-34 PREDICTED: Bactrocera dorsalis probable ATP-dependent RNA helicase DDX10 (LOC105222182), mRNA K08518 STXBP5 syntaxin-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08518 Q9WU70 2011 2.2e-223 Syntaxin-binding protein 5 OS=Rattus norvegicus GN=Stxbp5 PE=1 SV=1 PF00957//PF11616//PF00802//PF11427//PF00400//PF04992//PF01218//PF00270 Synaptobrevin//WD repeat binding protein EZH2//Pneumovirus attachment glycoprotein G//Tc3 transposase//WD domain, G-beta repeat//RNA polymerase Rpb1, domain 6//Coproporphyrinogen III oxidase//DEAD/DEAH box helicase GO:0055114//GO:0006554//GO:0006779//GO:0016192//GO:0006206//GO:0006479//GO:0006351//GO:0015994//GO:0006144 oxidation-reduction process//lysine catabolic process//porphyrin-containing compound biosynthetic process//vesicle-mediated transport//pyrimidine nucleobase metabolic process//protein methylation//transcription, DNA-templated//chlorophyll metabolic process//purine nucleobase metabolic process GO:0005524//GO:0003899//GO:0003676//GO:0018024//GO:0003677//GO:0005515//GO:0004109 ATP binding//DNA-directed RNA polymerase activity//nucleic acid binding//histone-lysine N-methyltransferase activity//DNA binding//protein binding//coproporphyrinogen oxidase activity GO:0005730//GO:0016021//GO:0055036 nucleolus//integral component of membrane//virion membrane KOG0343 RNA Helicase Cluster-8309.39035 BF_2 514.26 12.16 2056 91094383 XP_971062.1 1109 3.4e-118 PREDICTED: alanyl-tRNA editing protein Aarsd1 [Tribolium castaneum]>gi|270014911|gb|EFA11359.1| hypothetical protein TcasGA2_TC011516 [Tribolium castaneum] 332375886 BT128123.1 64 2.45117e-22 Dendroctonus ponderosae clone DPO1131_O04 unknown mRNA K07050 AARSD1, ALAX misacylated tRNA(Ala) deacylase http://www.genome.jp/dbget-bin/www_bget?ko:K07050 Q7ZYJ9 779 2.6e-81 Alanyl-tRNA editing protein Aarsd1-B OS=Xenopus laevis GN=aarsd1-b PE=2 SV=1 PF01176//PF07973//PF01411//PF01200//PF03367 Translation initiation factor 1A / IF-1//Threonyl and Alanyl tRNA synthetase second additional domain//tRNA synthetases class II (A)//Ribosomal protein S28e//ZPR1 zinc-finger domain GO:0006419//GO:0006412//GO:0006446//GO:0006531//GO:0006413//GO:0006522//GO:0043039//GO:0042254 alanyl-tRNA aminoacylation//translation//regulation of translational initiation//aspartate metabolic process//translational initiation//alanine metabolic process//tRNA aminoacylation//ribosome biogenesis GO:0003723//GO:0004813//GO:0003676//GO:0003743//GO:0005524//GO:0003735//GO:0000166//GO:0008270//GO:0016876 RNA binding//alanine-tRNA ligase activity//nucleic acid binding//translation initiation factor activity//ATP binding//structural constituent of ribosome//nucleotide binding//zinc ion binding//ligase activity, forming aminoacyl-tRNA and related compounds GO:0005622//GO:0005840//GO:0005737 intracellular//ribosome//cytoplasm KOG3502 40S ribosomal protein S28 Cluster-8309.39038 BF_2 74.62 1.34 2609 642916614 XP_008191899.1 1314 7.3e-142 PREDICTED: LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [Tribolium castaneum] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 3.2e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.39039 BF_2 199.65 2.66 3424 478257607 ENN77759.1 744 1.2e-75 hypothetical protein YQE_05731, partial [Dendroctonus ponderosae]>gi|546677511|gb|ERL88337.1| hypothetical protein D910_05724, partial [Dendroctonus ponderosae] -- -- -- -- -- K09880 mtnC, ENOPH1 enolase-phosphatase E1 http://www.genome.jp/dbget-bin/www_bget?ko:K09880 Q17Q32 446 1.8e-42 Enolase-phosphatase E1 OS=Aedes aegypti GN=AAEL000109 PE=3 SV=1 PF12689 Acid Phosphatase -- -- GO:0016791 phosphatase activity -- -- KOG2630 Enolase-phosphatase E-1 Cluster-8309.3904 BF_2 54.67 2.13 1363 91094905 XP_973449.1 1340 3.7e-145 PREDICTED: F-box/SPRY domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270006590|gb|EFA03038.1| hypothetical protein TcasGA2_TC010464 [Tribolium castaneum] 242007554 XM_002424560.1 192 1.12771e-93 Pediculus humanus corporis F-box/SPRY-domain protein, putative, mRNA K10319 FBXO45 F-box protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K10319 B4HQ29 1187 8.3e-129 F-box/SPRY domain-containing protein 1 OS=Drosophila sechellia GN=Fsn PE=3 SV=1 PF00646//PF12937//PF00622 F-box domain//F-box-like//SPRY domain -- -- GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.39040 BF_2 583.00 15.18 1894 478256079 ENN76278.1 755 3.5e-77 hypothetical protein YQE_07242, partial [Dendroctonus ponderosae]>gi|546676009|gb|ERL87104.1| hypothetical protein D910_04504 [Dendroctonus ponderosae] 617638670 XM_007531235.1 76 4.81197e-29 PREDICTED: Erinaceus europaeus oligosaccharyltransferase complex subunit (non-catalytic) (OSTC), mRNA -- -- -- -- Q5M9B7 574 1.4e-57 Oligosaccharyltransferase complex subunit ostc-B OS=Xenopus laevis GN=ostc-b PE=2 SV=1 PF13202//PF12763//PF13833//PF10591//PF13405//PF00036//PF13499 EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF-hand domain pair GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG3356 Predicted membrane protein Cluster-8309.39041 BF_2 26.82 0.34 3582 91082907 XP_972373.1 1236 1.1e-132 PREDICTED: S-formylglutathione hydrolase [Tribolium castaneum]>gi|270007612|gb|EFA04060.1| hypothetical protein TcasGA2_TC014293 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 1004 3.6e-107 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF00787//PF07224//PF12740//PF00326//PF10503 PX domain//Chlorophyllase//Chlorophyllase enzyme//Prolyl oligopeptidase family//Esterase PHB depolymerase GO:0046294//GO:0015994//GO:0015996//GO:0015947//GO:0006508 formaldehyde catabolic process//chlorophyll metabolic process//chlorophyll catabolic process//methane metabolic process//proteolysis GO:0035091//GO:0047746//GO:0008236//GO:0018738 phosphatidylinositol binding//chlorophyllase activity//serine-type peptidase activity//S-formylglutathione hydrolase activity GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.39043 BF_2 1513.60 5.46 11893 642918413 XP_008191462.1 2522 2.8e-281 PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|642918415|ref|XP_008191463.1| PREDICTED: carnitine O-palmitoyltransferase 1, liver isoform isoform X1 [Tribolium castaneum]>gi|270003254|gb|EEZ99701.1| hypothetical protein TcasGA2_TC002462 [Tribolium castaneum] 642931619 XM_966443.2 176 7.88888e-84 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K08765 CPT1A carnitine O-palmitoyltransferase 1, liver isoform http://www.genome.jp/dbget-bin/www_bget?ko:K08765 P50416 1614 2.2e-177 Carnitine O-palmitoyltransferase 1, liver isoform OS=Homo sapiens GN=CPT1A PE=1 SV=2 PF01532//PF00755 Glycosyl hydrolase family 47//Choline/Carnitine o-acyltransferase GO:0005975 carbohydrate metabolic process GO:0004571//GO:0016746//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups//calcium ion binding GO:0016020 membrane KOG2430 Glycosyl hydrolase, family 47 Cluster-8309.39045 BF_2 2945.31 56.68 2461 817086172 XP_012265802.1 1842 4.1e-203 PREDICTED: stress-induced-phosphoprotein 1 isoform X2 [Athalia rosae] 831315386 XM_012834849.1 54 1.06578e-16 PREDICTED: Clupea harengus stress-induced phosphoprotein 1 (stip1), mRNA K09553 STIP1 stress-induced-phosphoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09553 Q4R8N7 1433 4.5e-157 Stress-induced-phosphoprotein 1 OS=Macaca fascicularis GN=STIP1 PE=2 SV=1 PF13181//PF02064//PF13174//PF13374//PF00515//PF13371//PF09392//PF13176//PF13414 Tetratricopeptide repeat//MAS20 protein import receptor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Tetratricopeptide repeat//TPR repeat GO:0006605//GO:0009405//GO:0006886//GO:0015031 protein targeting//pathogenesis//intracellular protein transport//protein transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG0548 Molecular co-chaperone STI1 Cluster-8309.39046 BF_2 694.23 4.44 6823 91082533 XP_973629.1 1823 1.8e-200 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X1 [Tribolium castaneum]>gi|270007557|gb|EFA04005.1| hypothetical protein TcasGA2_TC014154 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14624 872 1.4e-91 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Homo sapiens GN=ITIH4 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.39047 BF_2 2120.96 71.33 1531 91084671 XP_966504.1 1223 1.5e-131 PREDICTED: lambda-crystallin [Tribolium castaneum]>gi|270008625|gb|EFA05073.1| hypothetical protein TcasGA2_TC015170 [Tribolium castaneum] -- -- -- -- -- K13247 CRYL1 L-gulonate 3-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K13247 Q811X6 788 1.7e-82 Lambda-crystallin homolog OS=Rattus norvegicus GN=Cryl1 PE=2 SV=3 PF12592//PF01210//PF00056//PF00070//PF03446//PF03721//PF02826//PF02737//PF07992//PF00725 Protein of unknown function (DUF3763)//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//lactate/malate dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain GO:0006552//GO:0006631//GO:0046168//GO:0018874//GO:0006098//GO:0006633//GO:0006554//GO:0055114//GO:0019521//GO:0006568//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//glycerol-3-phosphate catabolic process//benzoate metabolic process//pentose-phosphate shunt//fatty acid biosynthetic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process//valine catabolic process//isoleucine catabolic process GO:0016820//GO:0016491//GO:0051287//GO:0070403//GO:0004616//GO:0003857//GO:0016616 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//oxidoreductase activity//NAD binding//NAD+ binding//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2305 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.39048 BF_2 119.77 1.70 3236 332375116 AEE62699.1 2415 1.9e-269 unknown [Dendroctonus ponderosae]>gi|546676201|gb|ERL87268.1| hypothetical protein D910_04664 [Dendroctonus ponderosae] -- -- -- -- -- K12825 SF3A1, SAP114 splicing factor 3A subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12825 Q8K4Z5 1372 7.0e-150 Splicing factor 3A subunit 1 OS=Mus musculus GN=Sf3a1 PE=1 SV=1 PF14560//PF00240//PF01805 Ubiquitin-like domain//Ubiquitin family//Surp module GO:0006396 RNA processing GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.39049 BF_2 2442.37 65.37 1850 189238186 XP_966734.2 2332 4.7e-260 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 768442048 XM_011564477.1 347 1.05645e-179 PREDICTED: Plutella xylostella coronin-6 (LOC105392798), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 2.3e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.3905 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39050 BF_2 2335.57 8.42 11895 270015748 EFA12196.1 1838 5.8e-202 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFU5 248 5.6e-19 Inositol polyphosphate multikinase OS=Homo sapiens GN=IPMK PE=1 SV=1 PF01218//PF08702//PF01105//PF00642//PF10473//PF13912//PF03938//PF05529//PF16716//PF00096//PF00867//PF03770//PF04111//PF00695 Coproporphyrinogen III oxidase//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//C2H2-type zinc finger//Outer membrane protein (OmpH-like)//B-cell receptor-associated protein 31-like//Bone marrow stromal antigen 2//Zinc finger, C2H2 type//XPG I-region//Inositol polyphosphate kinase//Autophagy protein Apg6//Major surface antigen from hepadnavirus GO:0006779//GO:0055114//GO:0006886//GO:0006810//GO:0051258//GO:0006914//GO:0007165//GO:0030168//GO:0051607//GO:0015994//GO:0016032 porphyrin-containing compound biosynthetic process//oxidation-reduction process//intracellular protein transport//transport//protein polymerization//autophagy//signal transduction//platelet activation//defense response to virus//chlorophyll metabolic process//viral process GO:0005102//GO:0051082//GO:0008440//GO:0008134//GO:0045502//GO:0046872//GO:0004518//GO:0030674//GO:0042803//GO:0004109 receptor binding//unfolded protein binding//inositol-1,4,5-trisphosphate 3-kinase activity//transcription factor binding//dynein binding//metal ion binding//nuclease activity//protein binding, bridging//protein homodimerization activity//coproporphyrinogen oxidase activity GO:0005577//GO:0016021//GO:0005667//GO:0005783//GO:0030286 fibrinogen complex//integral component of membrane//transcription factor complex//endoplasmic reticulum//dynein complex -- -- Cluster-8309.39053 BF_2 2722.76 64.03 2066 642934646 XP_972350.2 538 5.5e-52 PREDICTED: uncharacterized protein LOC661069 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CJ61 206 7.2e-15 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Mus musculus GN=Cmtm4 PE=2 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.39054 BF_2 2318.39 73.59 1605 642939230 XP_008194770.1 1351 2.3e-146 PREDICTED: uncharacterized protein LOC656988 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39055 BF_2 410.39 3.12 5787 642936966 XP_008198632.1 3242 0.0e+00 PREDICTED: rab GTPase-activating protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 1662 2.9e-183 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 PF07776//PF08127//PF14719//PF00096//PF00170//PF16622//PF07660//PF13912//PF02892//PF00640//PF05443//PF13465//PF08649 Zinc-finger associated domain (zf-AD)//Peptidase family C1 propeptide//Phosphotyrosine interaction domain (PTB/PID)//Zinc finger, C2H2 type//bZIP transcription factor//zinc-finger C2H2-type//Secretin and TonB N terminus short domain//C2H2-type zinc finger//BED zinc finger//Phosphotyrosine interaction domain (PTB/PID)//ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//DASH complex subunit Dad1 GO:0006508//GO:0050790//GO:0030472//GO:0006355 proteolysis//regulation of catalytic activity//mitotic spindle organization in nucleus//regulation of transcription, DNA-templated GO:0046872//GO:0004197//GO:0003677//GO:0005515//GO:0043565//GO:0008270//GO:0003700 metal ion binding//cysteine-type endopeptidase activity//DNA binding//protein binding//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0072686//GO:0019867//GO:0005634//GO:0005667//GO:0042729 mitotic spindle//outer membrane//nucleus//transcription factor complex//DASH complex -- -- Cluster-8309.39056 BF_2 1254.10 12.48 4491 270003174 EEZ99621.1 2428 8.4e-271 hypothetical protein TcasGA2_TC002139 [Tribolium castaneum] 817079739 XM_012406879.1 41 3.29722e-09 PREDICTED: Athalia rosae thioredoxin-related transmembrane protein 1-like (LOC105689684), mRNA K14832 MAK21, NOC1, CEBPZ ribosome biogenesis protein MAK21 http://www.genome.jp/dbget-bin/www_bget?ko:K14832 Q03701 1316 3.0e-143 CCAAT/enhancer-binding protein zeta OS=Homo sapiens GN=CEBPZ PE=1 SV=3 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein Cluster-8309.39061 BF_2 2231.40 22.99 4348 665814511 XP_008555868.1 4780 0.0e+00 PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor]>gi|665814513|ref|XP_008555869.1| PREDICTED: regulator of nonsense transcripts 1 homolog isoform X1 [Microplitis demolitor] 749751938 XM_011139992.1 608 0 PREDICTED: Harpegnathos saltator regulator of nonsense transcripts 1 (LOC105182511), transcript variant X4, mRNA K14326 UPF1, RENT1 regulator of nonsense transcripts 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14326 Q9EPU0 3940 0.0e+00 Regulator of nonsense transcripts 1 OS=Mus musculus GN=Upf1 PE=1 SV=2 PF00580//PF04851//PF00270//PF07728//PF00004//PF00437//PF09416//PF00448 UvrD/REP helicase N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//RNA helicase (UPF2 interacting domain)//SRP54-type protein, GTPase domain GO:0006810//GO:0000184//GO:0006614 transport//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//SRP-dependent cotranslational protein targeting to membrane GO:0008270//GO:0005525//GO:0003676//GO:0016887//GO:0005524//GO:0004386//GO:0016787//GO:0003677 zinc ion binding//GTP binding//nucleic acid binding//ATPase activity//ATP binding//helicase activity//hydrolase activity//DNA binding GO:0005737 cytoplasm KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.39063 BF_2 154.71 2.09 3385 642912940 XP_008201316.1 860 4.2e-89 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80034 565 2.8e-56 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF12822//PF01080 Protein of unknown function (DUF3816)//Presenilin GO:0006810 transport GO:0004190//GO:0005215 aspartic-type endopeptidase activity//transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.39065 BF_2 2638.31 26.41 4466 642939347 XP_970218.2 2431 3.7e-271 PREDICTED: lipase maturation factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKZ9 1010 9.1e-108 Lipase maturation factor 2 OS=Gallus gallus GN=LMF2 PE=2 SV=2 PF01741 Large-conductance mechanosensitive channel, MscL GO:0006811//GO:0006810 ion transport//transport GO:0005216 ion channel activity GO:0016021 integral component of membrane -- -- Cluster-8309.39066 BF_2 63.73 2.70 1276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39068 BF_2 134.28 1.68 3627 546680789 ERL90995.1 1581 1.1e-172 hypothetical protein D910_08337 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 288 3.9e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF00856//PF00089 SET domain//Trypsin GO:0006508 proteolysis GO:0005515//GO:0004252 protein binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.39069 BF_2 438.91 4.28 4580 642912316 XP_969236.2 1282 6.6e-138 PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum]>gi|642912318|ref|XP_008200646.1| PREDICTED: NHL repeat-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IF69 737 4.2e-76 NHL repeat-containing protein 2 OS=Bos taurus GN=NHLRC2 PE=2 SV=1 PF01731//PF00085//PF01436//PF00578 Arylesterase//Thioredoxin//NHL repeat//AhpC/TSA family GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0005515//GO:0004064//GO:0016209 oxidoreductase activity//protein binding//arylesterase activity//antioxidant activity -- -- -- -- Cluster-8309.39070 BF_2 80.37 0.77 4650 642924423 XP_008194290.1 642 1.1e-63 PREDICTED: actin-binding Rho-activating protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N0Z2 271 4.7e-22 Actin-binding Rho-activating protein OS=Homo sapiens GN=ABRA PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3376 Uncharacterized conserved protein Cluster-8309.39071 BF_2 316.27 2.76 5076 478263483 ENN81838.1 154 4.6e-07 hypothetical protein YQE_01777, partial [Dendroctonus ponderosae]>gi|546685487|gb|ERL94985.1| hypothetical protein D910_12257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39072 BF_2 732.48 9.47 3522 642932977 XP_008197213.1 525 3.0e-50 PREDICTED: BUB3-interacting and GLEBS motif-containing protein ZNF207 isoform X2 [Tribolium castaneum] 524881414 XM_005097302.1 92 1.15049e-37 PREDICTED: Aplysia californica BUB3-interacting and GLEBS motif-containing protein ZNF207-like (LOC101854635), mRNA -- -- -- -- Q7ZXV8 416 5.4e-39 BUB3-interacting and GLEBS motif-containing protein ZNF207 OS=Xenopus laevis GN=znf207 PE=1 SV=1 PF00096//PF06467//PF02892 Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//BED zinc finger -- -- GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding -- -- KOG2893 Zn finger protein Cluster-8309.39073 BF_2 1794.55 18.74 4294 282165741 NP_001164113.1 2648 2.5e-296 cap-n-collar [Tribolium castaneum] -- -- -- -- -- K09041 NFE2N, CNC nuclear factor erythroid 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09041 P20482 882 6.1e-93 Segmentation protein cap'n'collar OS=Drosophila melanogaster GN=cnc PE=2 SV=3 PF07716//PF00170//PF03131//PF03126 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor//Plus-3 domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3863 bZIP transcription factor NRF1 Cluster-8309.39074 BF_2 1067.74 4.39 10467 642913929 XP_008201218.1 1980 1.7e-218 PREDICTED: headcase protein [Tribolium castaneum] 642913928 XM_008202996.1 693 0 PREDICTED: Tribolium castaneum headcase protein (LOC664275), mRNA -- -- -- -- Q9N2M8 849 1.0e-88 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 PF10403//PF02701 Rad4 beta-hairpin domain 1//Dof domain, zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3816 Cell differentiation regulator of the Headcase family Cluster-8309.39076 BF_2 1124.51 17.03 3049 642922790 XP_008193326.1 1286 1.5e-138 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 688 1.4e-70 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39078 BF_2 368.22 9.33 1939 189235966 XP_969617.2 810 1.5e-83 PREDICTED: zinc finger CCCH domain-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXZ2 320 4.1e-28 Zinc finger CCCH domain-containing protein 3 OS=Homo sapiens GN=ZC3H3 PE=1 SV=3 PF00642//PF00711 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Beta defensin GO:0006952 defense response GO:0046872 metal ion binding GO:0005576 extracellular region KOG1492 C3H1-type Zn-finger protein Cluster-8309.39079 BF_2 101.17 2.11 2295 728416984 AIY68330.1 1410 4.7e-153 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01050 BCHE cholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01050 P35502 650 2.6e-66 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.39080 BF_2 1050.60 16.15 3008 328777746 XP_396692.3 823 7.2e-85 PREDICTED: roughened isoform X3 [Apis mellifera]>gi|340717290|ref|XP_003397118.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|350407287|ref|XP_003488045.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|380017382|ref|XP_003692636.1| PREDICTED: ras-like protein 3 [Apis florea]>gi|571537886|ref|XP_006558879.1| PREDICTED: roughened isoform X1 [Apis mellifera]>gi|571537889|ref|XP_006558880.1| PREDICTED: roughened isoform X2 [Apis mellifera]>gi|572258774|ref|XP_006607754.1| PREDICTED: ras-like protein 3-like isoform X1 [Apis dorsata]>gi|572258776|ref|XP_006607755.1| PREDICTED: ras-like protein 3-like isoform X2 [Apis dorsata]>gi|572258778|ref|XP_006607756.1| PREDICTED: ras-like protein 3-like isoform X3 [Apis dorsata]>gi|572258780|ref|XP_006607757.1| PREDICTED: ras-like protein 3-like isoform X4 [Apis dorsata]>gi|808126889|ref|XP_012166429.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126891|ref|XP_012166430.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126893|ref|XP_012166431.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|815906255|ref|XP_012238943.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906257|ref|XP_012238944.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906259|ref|XP_012238945.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|169668013|gb|ACA64426.1| RAS-like protein [Bombus ignitus] 642938605 XM_008201640.1 384 0 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 803 6.2e-84 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF00071//PF00025//PF00268//PF01926//PF03193//PF08477 Ras family//ADP-ribosylation factor family//Ribonucleotide reductase, small chain//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0055114//GO:0006184//GO:0009186 small GTPase mediated signal transduction//oxidation-reduction process//obsolete GTP catabolic process//deoxyribonucleoside diphosphate metabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.39082 BF_2 2195.66 26.01 3818 91084051 XP_967428.1 4920 0.0e+00 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] 642924822 XM_962335.2 787 0 PREDICTED: Tribolium castaneum importin-5 (LOC655773), mRNA -- -- -- -- Q8BKC5 2943 0.0e+00 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF09044//PF01602//PF00514//PF03810//PF02985 Kp4//Adaptin N terminal region//Armadillo/beta-catenin-like repeat//Importin-beta N-terminal domain//HEAT repeat GO:0016192//GO:0006886//GO:0009405 vesicle-mediated transport//intracellular protein transport//pathogenesis GO:0005515//GO:0008536 protein binding//Ran GTPase binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.39083 BF_2 6055.87 94.67 2963 91088789 XP_968000.1 1311 1.8e-141 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02833 361 1.1e-32 Insulin-like growth factor-binding protein complex acid labile subunit OS=Papio hamadryas GN=IGFALS PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.39084 BF_2 1146.88 13.21 3919 91084051 XP_967428.1 4713 0.0e+00 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] 642924822 XM_962335.2 756 0 PREDICTED: Tribolium castaneum importin-5 (LOC655773), mRNA -- -- -- -- Q8BKC5 2888 0.0e+00 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF00514//PF01602//PF09044//PF03810//PF02985 Armadillo/beta-catenin-like repeat//Adaptin N terminal region//Kp4//Importin-beta N-terminal domain//HEAT repeat GO:0016192//GO:0006886//GO:0009405 vesicle-mediated transport//intracellular protein transport//pathogenesis GO:0005515//GO:0008536 protein binding//Ran GTPase binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.39085 BF_2 183.55 4.85 1871 291170322 ADD82417.1 230 2.6e-16 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39088 BF_2 110.48 0.35 13392 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 8.57747e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 878 5.5e-92 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF07975//PF13465//PF01426//PF05121//PF08273//PF02845//PF13912//PF09182//PF00412//PF00641//PF05495//PF00096//PF07776//PF13806 TFIIH C1-like domain//Zinc-finger double domain//BAH domain//Gas vesicle protein K//Zinc-binding domain of primase-helicase//CUE domain//C2H2-type zinc finger//Bacterial purine repressor, N-terminal//LIM domain//Zn-finger in Ran binding protein and others//CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Rieske-like [2Fe-2S] domain GO:0006269//GO:0006355//GO:0055114//GO:0006281//GO:0031412//GO:0006807//GO:0006351//GO:0042128 DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//oxidation-reduction process//DNA repair//gas vesicle organization//nitrogen compound metabolic process//transcription, DNA-templated//nitrate assimilation GO:0008942//GO:0008270//GO:0003682//GO:0003896//GO:0046872//GO:0003677//GO:0004386//GO:0005515 nitrite reductase [NAD(P)H] activity//zinc ion binding//chromatin binding//DNA primase activity//metal ion binding//DNA binding//helicase activity//protein binding GO:0005730//GO:0000785//GO:0005657//GO:0005634 nucleolus//chromatin//replication fork//nucleus -- -- Cluster-8309.39089 BF_2 476.00 11.00 2098 91078804 XP_970300.1 2079 1.2e-230 PREDICTED: glycosyltransferase 25 family member [Tribolium castaneum]>gi|270003725|gb|EFA00173.1| hypothetical protein TcasGA2_TC002995 [Tribolium castaneum] -- -- -- -- -- K11703 GLT25D collagen beta-1,O-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11703 Q17FB8 1510 4.5e-166 Glycosyltransferase 25 family member OS=Aedes aegypti GN=AAEL003481 PE=3 SV=1 -- -- GO:0009103 lipopolysaccharide biosynthetic process -- -- -- -- KOG4179 Lysyl hydrolase/glycosyltransferase family 25 Cluster-8309.39090 BF_2 52.51 0.54 4385 270001798 EEZ98245.1 3524 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 468 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q10057 146 1.4e-07 Putative protein disulfide-isomerase C1F5.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC1F5.02 PE=3 SV=1 PF02382//PF00085//PF01791//PF02020 RTX N-terminal domain//Thioredoxin//DeoC/LacD family aldolase//eIF4-gamma/eIF5/eIF2-epsilon GO:0045454//GO:0009405 cell redox homeostasis//pathogenesis GO:0016829//GO:0005515//GO:0005509 lyase activity//protein binding//calcium ion binding GO:0005576 extracellular region KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.39091 BF_2 2772.00 771.29 437 264667391 ACY71281.1 534 3.4e-52 ribosomal protein S6 [Chrysomela tremula] 462382418 APGK01021662.1 96 7.97552e-41 Dendroctonus ponderosae Seq01021672, whole genome shotgun sequence K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q94624 511 6.5e-51 40S ribosomal protein S6 OS=Manduca sexta GN=RpS6 PE=2 SV=1 PF01092 Ribosomal protein S6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1646 40S ribosomal protein S6 Cluster-8309.39092 BF_2 24.85 0.32 3586 91082905 XP_972330.1 2058 5.4e-228 PREDICTED: eukaryotic translation initiation factor 2A [Tribolium castaneum]>gi|270007067|gb|EFA03515.1| hypothetical protein TcasGA2_TC013517 [Tribolium castaneum] -- -- -- -- -- K15026 EIF2A translation initiation factor 2A http://www.genome.jp/dbget-bin/www_bget?ko:K15026 Q7ZY11 1191 7.5e-129 Eukaryotic translation initiation factor 2A OS=Xenopus laevis GN=eif2a PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG2315 Predicted translation initiation factor related to eIF-3a Cluster-8309.39093 BF_2 148.44 6.99 1175 795378639 XP_011937115.1 412 1.3e-37 PREDICTED: 40S ribosomal protein S9 isoform X1 [Cercocebus atys]>gi|795378643|ref|XP_011937116.1| PREDICTED: 40S ribosomal protein S9 isoform X1 [Cercocebus atys] 642933492 XM_962542.2 120 1.02443e-53 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 327 3.8e-29 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain -- -- GO:0019843//GO:0003723 rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.39094 BF_2 7.44 0.67 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39095 BF_2 2216.00 113.77 1102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39096 BF_2 1275.11 10.33 5453 642924931 XP_008194102.1 343 6.0e-29 PREDICTED: uncharacterized protein LOC103313203 [Tribolium castaneum]>gi|642924933|ref|XP_008194103.1| PREDICTED: uncharacterized protein LOC103313203 [Tribolium castaneum]>gi|642924935|ref|XP_008194105.1| PREDICTED: uncharacterized protein LOC103313203 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15001 AP-5 complex subunit sigma-1 GO:0000724//GO:0016197 double-strand break repair via homologous recombination//endosomal transport -- -- GO:0030119 AP-type membrane coat adaptor complex -- -- Cluster-8309.39097 BF_2 1143.31 16.10 3258 328777746 XP_396692.3 823 7.8e-85 PREDICTED: roughened isoform X3 [Apis mellifera]>gi|340717290|ref|XP_003397118.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|350407287|ref|XP_003488045.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|380017382|ref|XP_003692636.1| PREDICTED: ras-like protein 3 [Apis florea]>gi|571537886|ref|XP_006558879.1| PREDICTED: roughened isoform X1 [Apis mellifera]>gi|571537889|ref|XP_006558880.1| PREDICTED: roughened isoform X2 [Apis mellifera]>gi|572258774|ref|XP_006607754.1| PREDICTED: ras-like protein 3-like isoform X1 [Apis dorsata]>gi|572258776|ref|XP_006607755.1| PREDICTED: ras-like protein 3-like isoform X2 [Apis dorsata]>gi|572258778|ref|XP_006607756.1| PREDICTED: ras-like protein 3-like isoform X3 [Apis dorsata]>gi|572258780|ref|XP_006607757.1| PREDICTED: ras-like protein 3-like isoform X4 [Apis dorsata]>gi|808126889|ref|XP_012166429.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126891|ref|XP_012166430.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126893|ref|XP_012166431.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|815906255|ref|XP_012238943.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906257|ref|XP_012238944.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906259|ref|XP_012238945.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|169668013|gb|ACA64426.1| RAS-like protein [Bombus ignitus] 642938605 XM_008201640.1 384 0 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 803 6.7e-84 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF00025//PF00071//PF00268//PF01926//PF08477//PF03193 ADP-ribosylation factor family//Ras family//Ribonucleotide reductase, small chain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0055114//GO:0007264//GO:0009186//GO:0006184 oxidation-reduction process//small GTPase mediated signal transduction//deoxyribonucleoside diphosphate metabolic process//obsolete GTP catabolic process GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.39098 BF_2 930.30 4.08 9821 642935327 XP_001809480.2 2942 0.0e+00 PREDICTED: uncharacterized protein LOC100141518 [Tribolium castaneum] 642935324 XM_008199747.1 553 0 PREDICTED: Tribolium castaneum RING finger protein nhl-1 (LOC656122), transcript variant X2, mRNA K12035 TRIM71 tripartite motif-containing protein 71 http://www.genome.jp/dbget-bin/www_bget?ko:K12035 Q03601 760 2.0e-78 RING finger protein nhl-1 OS=Caenorhabditis elegans GN=nhl-1 PE=1 SV=2 PF13639//PF04566//PF10588//PF04513//PF00651//PF01436//PF08165//PF00097//PF03884//PF01601//PF14634//PF00643 Ring finger domain//RNA polymerase Rpb2, domain 4//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//Baculovirus polyhedron envelope protein, PEP, C terminus//BTB/POZ domain//NHL repeat//FerA (NUC095) domain//Zinc finger, C3HC4 type (RING finger)//Domain of unknown function (DUF329)//Coronavirus S2 glycoprotein//zinc-RING finger domain//B-box zinc finger GO:0006144//GO:0006351//GO:0046813//GO:0061025//GO:0006206//GO:0055114 purine nucleobase metabolic process//transcription, DNA-templated//receptor-mediated virion attachment to host cell//membrane fusion//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0016491//GO:0005515//GO:0003677//GO:0046872//GO:0005198//GO:0003899//GO:0008270 oxidoreductase activity//protein binding//DNA binding//metal ion binding//structural molecule activity//DNA-directed RNA polymerase activity//zinc ion binding GO:0019031//GO:0016021//GO:0019028//GO:0005730//GO:0005622 viral envelope//integral component of membrane//viral capsid//nucleolus//intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.39099 BF_2 69.65 1.30 2520 55978158 AAV68692.1 1095 1.7e-116 putative IDGF [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- Q9W303 720 2.2e-74 Chitinase-like protein Idgf4 OS=Drosophila melanogaster GN=Idgf4 PE=2 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.39101 BF_2 3416.99 11.09 13171 642931031 XP_008196185.1 5942 0.0e+00 PREDICTED: Ig-like and fibronectin type-III domain-containing protein T04A11.3 [Tribolium castaneum] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 Q964T2 917 1.6e-96 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF01313//PF04142//PF01108//PF04893//PF16656//PF00041//PF13895//PF01266//PF00067//PF00892 Bacterial export proteins, family 3//Nucleotide-sugar transporter//Tissue factor//Yip1 domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//FAD dependent oxidoreductase//Cytochrome P450//EamA-like transporter family GO:0019497//GO:0009306//GO:0055114//GO:0008643//GO:0006771 hexachlorocyclohexane metabolic process//protein secretion//oxidation-reduction process//carbohydrate transport//riboflavin metabolic process GO:0005351//GO:0005506//GO:0003993//GO:0005515//GO:0016491//GO:0016705//GO:0046872//GO:0020037 sugar:proton symporter activity//iron ion binding//acid phosphatase activity//protein binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//metal ion binding//heme binding GO:0016021//GO:0016020//GO:0000139 integral component of membrane//membrane//Golgi membrane -- -- Cluster-8309.39102 BF_2 1790.96 22.43 3628 91088643 XP_974406.1 953 7.3e-100 PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|642931990|ref|XP_008196810.1| PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|642931992|ref|XP_008196811.1| PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|270011686|gb|EFA08134.1| hypothetical protein TcasGA2_TC005738 [Tribolium castaneum] -- -- -- -- -- K12163 ANUBL1 AN1-type zinc finger and ubiquitin domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12163 D3Z3C6 316 2.2e-27 AN1-type zinc finger protein 4 OS=Mus musculus GN=Zfand4 PE=3 SV=2 PF00558//PF01764//PF00240//PF14560//PF01428 Vpu protein//Lipase (class 3)//Ubiquitin family//Ubiquitin-like domain//AN1-like Zinc finger GO:0019076//GO:0006629//GO:0006812//GO:0032801 viral release from host cell//lipid metabolic process//cation transport//receptor catabolic process GO:0005515//GO:0005261//GO:0008270 protein binding//cation channel activity//zinc ion binding GO:0033644 host cell membrane KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.39103 BF_2 346.24 18.06 1089 741829289 AJA91071.1 616 2.6e-61 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 365 1.4e-33 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00203//PF00067 Ribosomal protein S19//Cytochrome P450 GO:0055114//GO:0042254//GO:0006412 oxidation-reduction process//ribosome biogenesis//translation GO:0003735//GO:0005506//GO:0020037//GO:0016705 structural constituent of ribosome//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005840 ribosome -- -- Cluster-8309.39105 BF_2 53.63 0.34 6816 642916047 XP_008190871.1 2817 0.0e+00 PREDICTED: ras-GEF domain-containing family member 1B-like isoform X3 [Tribolium castaneum] 808119259 XM_012307759.1 168 1.26304e-79 PREDICTED: Bombus terrestris ras-GEF domain-containing family member 1B-like (LOC100645439), transcript variant X2, mRNA -- -- -- -- Q6DHR3 1318 2.7e-143 Ras-GEF domain-containing family member 1B-A OS=Danio rerio GN=rasgef1ba PE=2 SV=2 PF13639//PF00412//PF00617 Ring finger domain//LIM domain//RasGEF domain GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0008270//GO:0005085//GO:0005515 zinc ion binding//guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3541 Predicted guanine nucleotide exchange factor Cluster-8309.39106 BF_2 173.12 1.05 7194 270012437 EFA08885.1 537 2.5e-51 hypothetical protein TcasGA2_TC006586 [Tribolium castaneum] 462297259 APGK01052086.1 102 6.51901e-43 Dendroctonus ponderosae Seq01052096, whole genome shotgun sequence -- -- -- -- Q9U6A1 504 6.9e-49 Homeobox protein prospero OS=Drosophila virilis GN=pros PE=3 SV=1 PF15556//PF13855//PF00560//PF05044//PF01874 ZW10 interactor//Leucine rich repeat//Leucine Rich Repeat//Homeo-prospero domain//ATP:dephospho-CoA triphosphoribosyl transferase GO:0007093//GO:0016310 mitotic cell cycle checkpoint//phosphorylation GO:0003677//GO:0005524//GO:0046917//GO:0005515 DNA binding//ATP binding//triphosphoribosyl-dephospho-CoA synthase activity//protein binding GO:0000776 kinetochore KOG3779 Homeobox transcription factor prospero Cluster-8309.39107 BF_2 65.53 1.37 2290 642915291 XP_008190557.1 1094 2.1e-116 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 762 2.7e-79 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF01602//PF00311//PF07571//PF02985//PF10410 Adaptin N terminal region//Phosphoenolpyruvate carboxylase//TAF6 C-terminal HEAT repeat domain//HEAT repeat//DnaB-helicase binding domain of primase GO:0015977//GO:0051090//GO:0006886//GO:0016192//GO:0019643//GO:0006094//GO:0006099 carbon fixation//regulation of sequence-specific DNA binding transcription factor activity//intracellular protein transport//vesicle-mediated transport//reductive tricarboxylic acid cycle//gluconeogenesis//tricarboxylic acid cycle GO:0008964//GO:0005515//GO:0016779 phosphoenolpyruvate carboxylase activity//protein binding//nucleotidyltransferase activity GO:0005634//GO:0030117 nucleus//membrane coat -- -- Cluster-8309.39108 BF_2 802.93 12.15 3051 524899886 XP_005106369.1 502 1.2e-47 PREDICTED: E3 ubiquitin-protein ligase mind-bomb-like isoform X1 [Aplysia californica] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 313 4.1e-27 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF00097//PF14634//PF15898//PF13639//PF06701//PF07663//PF00569 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//cGMP-dependent protein kinase interacting domain//Ring finger domain//Mib_herc2//Sorbitol phosphotransferase enzyme II C-terminus//Zinc finger, ZZ type GO:0016567//GO:0008643//GO:0009401 protein ubiquitination//carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0004842//GO:0005515//GO:0046872//GO:0008270//GO:0008982//GO:0019901 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase binding GO:0016021//GO:0009357 integral component of membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.39109 BF_2 175.00 5.14 1712 270013380 EFA09828.1 813 5.9e-84 hypothetical protein TcasGA2_TC011975 [Tribolium castaneum] 815898402 XM_003485921.2 105 3.28523e-45 PREDICTED: Bombus impatiens ubiquitin-conjugating enzyme E2 S (LOC100749747), mRNA K10583 UBE2S, E2EPF ubiquitin-conjugating enzyme E2 S http://www.genome.jp/dbget-bin/www_bget?ko:K10583 B4N208 711 1.6e-73 Ubiquitin-conjugating enzyme E2 S OS=Drosophila willistoni GN=GK16201 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0423 Ubiquitin-protein ligase Cluster-8309.39112 BF_2 51.94 0.86 2824 332376452 AEE63366.1 839 9.5e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08360 CYB561 cytochrome b-561 http://www.genome.jp/dbget-bin/www_bget?ko:K08360 P34465 448 8.5e-43 Putative cytochrome b561 OS=Caenorhabditis elegans GN=F55H2.5 PE=3 SV=1 PF01292//PF03188//PF03124 Prokaryotic cytochrome b561//Eukaryotic cytochrome b561//EXS family GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.39113 BF_2 158.23 1.73 4114 91084051 XP_967428.1 2768 2.9e-310 PREDICTED: importin-5 [Tribolium castaneum]>gi|270006692|gb|EFA03140.1| hypothetical protein TcasGA2_TC013052 [Tribolium castaneum] 642924822 XM_962335.2 376 0 PREDICTED: Tribolium castaneum importin-5 (LOC655773), mRNA -- -- -- -- Q8BKC5 1716 1.1e-189 Importin-5 OS=Mus musculus GN=Ipo5 PE=1 SV=3 PF03810//PF02985//PF01602//PF09044 Importin-beta N-terminal domain//HEAT repeat//Adaptin N terminal region//Kp4 GO:0016192//GO:0006886//GO:0009405 vesicle-mediated transport//intracellular protein transport//pathogenesis GO:0008536//GO:0005515 Ran GTPase binding//protein binding GO:0030117//GO:0005576 membrane coat//extracellular region KOG2171 Karyopherin (importin) beta 3 Cluster-8309.39114 BF_2 1090.04 14.29 3477 546672689 ERL84480.1 2032 5.4e-225 hypothetical protein D910_01911 [Dendroctonus ponderosae] 807020276 XM_004520531.2 44 5.47387e-11 PREDICTED: Ceratitis capitata putative ATPase N2B (LOC101449143), mRNA K14855 RSA4, NLE1 ribosome assembly protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14855 Q58D20 1615 5.0e-178 Notchless protein homolog 1 OS=Bos taurus GN=NLE1 PE=2 SV=3 PF03969//PF00004//PF00400 AFG1-like ATPase//ATPase family associated with various cellular activities (AAA)//WD domain, G-beta repeat -- -- GO:0005515//GO:0005524 protein binding//ATP binding -- -- KOG0271 Notchless-like WD40 repeat-containing protein Cluster-8309.39118 BF_2 1761.82 8.38 9084 642922965 XP_008200471.1 11133 0.0e+00 PREDICTED: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1 [Tribolium castaneum] 642922964 XM_008202249.1 1875 0 PREDICTED: Tribolium castaneum probable ubiquitin carboxyl-terminal hydrolase FAF-X (LOC661487), transcript variant X1, mRNA K11840 USP9_24 ubiquitin carboxyl-terminal hydrolase 9/24 http://www.genome.jp/dbget-bin/www_bget?ko:K11840 P70398 6863 0.0e+00 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus GN=Usp9x PE=1 SV=2 PF11093//PF00443 Mitochondrial export protein Som1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG1866 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.39120 BF_2 35.54 1.51 1270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39122 BF_2 979.97 21.24 2217 546678047 ERL88771.1 2194 5.6e-244 hypothetical protein D910_06153 [Dendroctonus ponderosae] -- -- -- -- -- K01277 DPP3 dipeptidyl-peptidase III http://www.genome.jp/dbget-bin/www_bget?ko:K01277 Q9VHR8 1550 1.1e-170 Dipeptidyl peptidase 3 OS=Drosophila melanogaster GN=DppIII PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3675 Dipeptidyl peptidase III Cluster-8309.39123 BF_2 6222.77 41.97 6489 642924534 XP_008194335.1 2139 3.9e-237 PREDICTED: junctophilin-1 isoform X2 [Tribolium castaneum] 642924533 XM_008196113.1 493 0 PREDICTED: Tribolium castaneum junctophilin-1 (LOC662408), transcript variant X2, mRNA K19530 JPH junctophilin http://www.genome.jp/dbget-bin/www_bget?ko:K19530 Q9ET80 1235 1.1e-133 Junctophilin-1 OS=Mus musculus GN=Jph1 PE=2 SV=1 PF01022//PF06112//PF04072 Bacterial regulatory protein, arsR family//Gammaherpesvirus capsid protein//Leucine carboxyl methyltransferase GO:0006355//GO:0032259 regulation of transcription, DNA-templated//methylation GO:0008168//GO:0003700 methyltransferase activity//transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0005667 viral capsid//transcription factor complex KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.39124 BF_2 940.24 20.72 2185 642924532 XP_008194334.1 1010 1.1e-106 PREDICTED: junctophilin-1 isoform X1 [Tribolium castaneum] 749744355 XM_011156377.1 145 2.44677e-67 PREDICTED: Harpegnathos saltator uncharacterized LOC105192324 (LOC105192324), mRNA K19530 JPH junctophilin http://www.genome.jp/dbget-bin/www_bget?ko:K19530 Q9GKY8 488 1.5e-47 Junctophilin-1 OS=Oryctolagus cuniculus GN=JPH1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0231 Junctional membrane complex protein Junctophilin and related MORN repeat proteins Cluster-8309.39125 BF_2 133.44 1.20 4948 389609327 BAM18275.1 521 1.2e-49 junctophilin [Papilio xuthus] 642924533 XM_008196113.1 85 1.2621e-33 PREDICTED: Tribolium castaneum junctophilin-1 (LOC662408), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01022 Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39126 BF_2 53.27 1.70 1598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07440//PF02468 Caerin 1 protein//Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0005576//GO:0016020//GO:0009539//GO:0009523 extracellular region//membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.39128 BF_2 1000.81 14.92 3093 270006832 EFA03280.1 841 6.1e-87 hypothetical protein TcasGA2_TC013215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C1T0 155 8.8e-09 Membrane metallo-endopeptidase-like 1 OS=Rattus norvegicus GN=Mmel1 PE=1 SV=1 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.39129 BF_2 1635.33 24.15 3120 270006832 EFA03280.1 841 6.1e-87 hypothetical protein TcasGA2_TC013215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0C1T0 155 8.9e-09 Membrane metallo-endopeptidase-like 1 OS=Rattus norvegicus GN=Mmel1 PE=1 SV=1 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.3913 BF_2 53.39 1.52 1758 642927265 XP_008195199.1 468 6.2e-44 PREDICTED: uncharacterized protein LOC103313525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39130 BF_2 358.60 1.94 8002 817062174 XP_012252727.1 8148 0.0e+00 PREDICTED: teneurin-m isoform X2 [Athalia rosae] 642919996 XM_008193938.1 1433 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 7492 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436//PF03222//PF00008 NHL repeat//Tryptophan/tyrosine permease family//EGF-like domain GO:0003333 amino acid transmembrane transport GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.39131 BF_2 165.00 8.92 1061 642932768 XP_008196975.1 563 3.6e-55 PREDICTED: uncharacterized protein LOC662560 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0007178//GO:0009069//GO:0016310//GO:0032222//GO:1903818//GO:0030431 transmembrane receptor protein serine/threonine kinase signaling pathway//serine family amino acid metabolic process//phosphorylation//regulation of synaptic transmission, cholinergic//positive regulation of voltage-gated potassium channel activity//sleep GO:0034235//GO:0004675 GPI anchor binding//transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.39132 BF_2 168.60 3.39 2368 642926818 XP_001810169.2 1798 5.0e-198 PREDICTED: uncharacterized protein LOC100142170 isoform X1 [Tribolium castaneum] 642926819 XM_008196805.1 196 1.18393e-95 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096 Altered inheritance of mitochondria protein 3 GO:0051016 barbed-end actin filament capping -- -- GO:0030479 actin cortical patch -- -- Cluster-8309.39133 BF_2 425.70 17.21 1322 642938243 XP_008198126.1 872 6.6e-91 PREDICTED: serine/threonine-protein kinase Doa isoform X1 [Tribolium castaneum] -- -- -- -- -- K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 176 1.4e-11 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF10399 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal GO:0006118//GO:0055114//GO:0006119//GO:0015992 obsolete electron transport//oxidation-reduction process//oxidative phosphorylation//proton transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- KOG0671 LAMMER dual specificity kinases Cluster-8309.39134 BF_2 655.00 78.32 637 189238710 XP_969341.2 1047 1.6e-111 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 642927019 XM_964248.3 106 3.28541e-46 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q9LJ64 197 2.4e-14 Pollen-specific leucine-rich repeat extensin-like protein 1 OS=Arabidopsis thaliana GN=PEX1 PE=2 SV=1 PF04204 Homoserine O-succinyltransferase GO:0006555//GO:0042967//GO:0019281 methionine metabolic process//acyl-carrier-protein biosynthetic process//L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine GO:0008899 homoserine O-succinyltransferase activity GO:0005737 cytoplasm -- -- Cluster-8309.39135 BF_2 1107.00 62.93 1023 546676659 ERL87623.1 1544 6.1e-169 hypothetical protein D910_05014 [Dendroctonus ponderosae] 642927019 XM_964248.3 198 3.88106e-97 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q8IXT5 209 1.6e-15 RNA-binding protein 12B OS=Homo sapiens GN=RBM12B PE=1 SV=2 PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.39138 BF_2 9236.71 41.22 9661 478255507 ENN75724.1 1979 2.1e-218 hypothetical protein YQE_07684, partial [Dendroctonus ponderosae] -- -- -- -- -- K17800 LETM1, MDM38 LETM1 and EF-hand domain-containing protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17800 P91927 1023 6.1e-109 LETM1 and EF-hand domain-containing protein anon-60Da, mitochondrial OS=Drosophila melanogaster GN=Letm1 PE=2 SV=2 PF13499 EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG1043 Ca2+-binding transmembrane protein LETM1/MRS7 Cluster-8309.39139 BF_2 377.28 3.07 5425 189238186 XP_966734.2 2332 1.4e-259 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 642925605 XM_008196416.1 565 0 PREDICTED: Tribolium castaneum hippocampus abundant transcript 1 protein (LOC661725), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 6.9e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF00400//PF07690 WD domain, G-beta repeat//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.39140 BF_2 33.43 0.46 3351 478256686 ENN76868.1 920 4.5e-96 hypothetical protein YQE_06709, partial [Dendroctonus ponderosae]>gi|546685117|gb|ERL94644.1| hypothetical protein D910_11919 [Dendroctonus ponderosae] -- -- -- -- -- K00944 AK3 nucleoside-triphosphate--adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00944 Q9WTP7 622 6.7e-63 GTP:AMP phosphotransferase AK3, mitochondrial OS=Mus musculus GN=Ak3 PE=1 SV=3 PF05191 Adenylate kinase, active site lid GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0004017 adenylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.39141 BF_2 287.28 3.04 4245 91086991 XP_973570.1 1379 3.4e-149 PREDICTED: maspardin [Tribolium castaneum]>gi|270010508|gb|EFA06956.1| hypothetical protein TcasGA2_TC009913 [Tribolium castaneum] -- -- -- -- -- K19367 SPG21 maspardin http://www.genome.jp/dbget-bin/www_bget?ko:K19367 Q6PC62 957 1.2e-101 Maspardin OS=Danio rerio GN=spg21 PE=2 SV=1 PF13145//PF00975 PPIC-type PPIASE domain//Thioesterase domain GO:0009058 biosynthetic process GO:0016853//GO:0016788 isomerase activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.39142 BF_2 300.00 4.39 3148 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39144 BF_2 380.74 12.03 1611 642912555 XP_008200909.1 1330 6.3e-144 PREDICTED: phosphatidylserine decarboxylase proenzyme isoform X1 [Tribolium castaneum]>gi|270002604|gb|EEZ99051.1| hypothetical protein TcasGA2_TC004926 [Tribolium castaneum] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q9UG56 767 5.0e-80 Phosphatidylserine decarboxylase proenzyme OS=Homo sapiens GN=PISD PE=2 SV=4 PF02666 Phosphatidylserine decarboxylase GO:0006563//GO:0006566//GO:0008654//GO:0046486//GO:0006544 L-serine metabolic process//threonine metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//glycine metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.39146 BF_2 65.42 1.53 2079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.39147 BF_2 109.14 0.73 6553 270003675 EFA00123.1 2706 7.1e-303 hypothetical protein TcasGA2_TC002939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R151 1145 3.0e-123 NFX1-type zinc finger-containing protein 1 OS=Mus musculus GN=Znfx1 PE=2 SV=3 PF00270//PF00004//PF01695//PF07728//PF02562//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//PhoH-like protein//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0003677//GO:0016787//GO:0016887//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATPase activity//ATP binding -- -- KOG1807 Helicases Cluster-8309.39148 BF_2 14.96 0.41 1798 568599608 AHE13799.1 269 7.5e-21 odorant binding protein [Lissorhoptrus oryzophilus] -- -- -- -- -- -- -- -- -- Q27017 158 2.3e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.39149 BF_2 41.94 0.31 6013 642923500 XP_008193535.1 431 4.1e-39 PREDICTED: flocculation protein FLO11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39151 BF_2 1158.93 15.45 3426 91077926 XP_974115.1 1002 1.4e-105 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] 689542246 LL999048.1 56 1.15092e-17 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_scaffold0000001 K04797 pfdA, PFDN5 prefoldin alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04797 Q5RAY0 360 1.6e-32 Prefoldin subunit 5 OS=Pongo abelii GN=PFDN5 PE=2 SV=1 PF05889//PF07684//PF01370//PF00106//PF12242 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//NOTCH protein//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0007275//GO:0008152//GO:0007219//GO:0055114//GO:0030154 multicellular organismal development//metabolic process//Notch signaling pathway//oxidation-reduction process//cell differentiation GO:0016491//GO:0016740//GO:0003824//GO:0050662//GO:0000166 oxidoreductase activity//transferase activity//catalytic activity//coenzyme binding//nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.39152 BF_2 365.19 3.73 4378 91089973 XP_973833.1 4993 0.0e+00 PREDICTED: exportin-1 [Tribolium castaneum]>gi|270013547|gb|EFA09995.1| hypothetical protein TcasGA2_TC012162 [Tribolium castaneum] 462343018 APGK01035523.1 865 0 Dendroctonus ponderosae Seq01035533, whole genome shotgun sequence K14290 XPO1, CRM1 exportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14290 Q80U96 4220 0.0e+00 Exportin-1 OS=Rattus norvegicus GN=Xpo1 PE=1 SV=1 PF03810 Importin-beta N-terminal domain GO:0015031//GO:0006886 protein transport//intracellular protein transport GO:0008536//GO:0008565 Ran GTPase binding//protein transporter activity GO:0005643 nuclear pore KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.39153 BF_2 349.73 3.76 4176 642925010 XP_008194133.1 4674 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X3 [Tribolium castaneum] 759033712 XM_011331767.1 146 1.30955e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X1, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3842 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03293//PF03540//PF03485//PF15014//PF05236 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Transcription initiation factor TFIID 23-30kDa subunit//Arginyl tRNA synthetase N terminal domain//Ceroid-lipofuscinosis neuronal protein 5//Transcription initiation factor TFIID component TAF4 family GO:0006206//GO:0006352//GO:0006351//GO:0006144//GO:0006560//GO:0006420//GO:0006525//GO:0019083//GO:0022008 pyrimidine nucleobase metabolic process//DNA-templated transcription, initiation//transcription, DNA-templated//purine nucleobase metabolic process//proline metabolic process//arginyl-tRNA aminoacylation//arginine metabolic process//viral transcription//neurogenesis GO:0003677//GO:0004814//GO:0000166//GO:0005524//GO:0003899 DNA binding//arginine-tRNA ligase activity//nucleotide binding//ATP binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005764//GO:0005669//GO:0005730//GO:0005737 nucleus//lysosome//transcription factor TFIID complex//nucleolus//cytoplasm KOG3635 Phosphorylase kinase Cluster-8309.39154 BF_2 4823.34 76.55 2923 642915413 XP_008190604.1 3450 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 5 isoform X1 [Tribolium castaneum] 170037221 XM_001846406.1 633 0 Culex quinquefasciatus chloride channel protein 3, mRNA K05012 CLCN3_4_5 chloride channel 3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K05012 P51790 2314 3.7e-259 H(+)/Cl(-) exchange transporter 3 OS=Homo sapiens GN=CLCN3 PE=1 SV=2 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0475 Cl- channel CLC-3 and related proteins (CLC superfamily) Cluster-8309.39156 BF_2 2288.24 67.80 1699 189237939 XP_001813105.1 1081 4.9e-115 PREDICTED: ras-related protein Rab-5B [Tribolium castaneum]>gi|270008253|gb|EFA04701.1| Rab-protein 5 [Tribolium castaneum] 557324471 XM_006035208.1 217 1.78949e-107 PREDICTED: Alligator sinensis RAB5B, member RAS oncogene family (RAB5B), transcript variant X2, mRNA K07889 RAB5C Ras-related protein Rab-5C http://www.genome.jp/dbget-bin/www_bget?ko:K07889 Q98932 855 3.3e-90 Ras-related protein Rab-5C OS=Gallus gallus GN=RAB5C PE=1 SV=1 PF00071//PF00025//PF04670//PF02241//PF01926//PF08477//PF03193 Ras family//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Methyl-coenzyme M reductase beta subunit, C-terminal domain//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0015031//GO:0046656//GO:0007264 protein transport//folic acid biosynthetic process//small GTPase mediated signal transduction GO:0050524//GO:0005525//GO:0003924 coenzyme-B sulfoethylthiotransferase activity//GTP binding//GTPase activity -- -- KOG0092 GTPase Rab5/YPT51 and related small G protein superfamily GTPases Cluster-8309.39157 BF_2 143.54 1.49 4310 642935850 XP_008198197.1 1025 3.9e-108 PREDICTED: protein aurora borealis [Tribolium castaneum]>gi|270013262|gb|EFA09710.1| hypothetical protein TcasGA2_TC011843 [Tribolium castaneum] 817085067 XM_012409782.1 125 6.37958e-56 PREDICTED: Athalia rosae E3 ubiquitin-protein ligase Hakai (LOC105691369), transcript variant X2, mRNA K15685 CBLL1 E3 ubiquitin-protein ligase Hakai http://www.genome.jp/dbget-bin/www_bget?ko:K15685 Q5ZHZ4 336 1.3e-29 E3 ubiquitin-protein ligase Hakai OS=Gallus gallus GN=CBLL1 PE=2 SV=1 PF14634//PF12235//PF00097//PF13639 zinc-RING finger domain//Fragile X-related 1 protein core C terminal//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0005515//GO:0046872//GO:0008270//GO:0003723 protein binding//metal ion binding//zinc ion binding//RNA binding -- -- KOG2932 E3 ubiquitin ligase involved in ubiquitination of E-cadherin complex Cluster-8309.39158 BF_2 1233.87 4.65 11377 642920053 XP_008192184.1 1927 2.6e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.84878e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.8e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03822//PF08159//PF08445//PF13508//PF00583//PF00341//PF00159//PF13673//PF03213//PF02297//PF03396 NAF domain//NUC153 domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//PDGF/VEGF domain//Pancreatic hormone peptide//Acetyltransferase (GNAT) domain//Poxvirus P35 protein//Cytochrome oxidase c subunit VIb//Poxvirus DNA-directed RNA polymerase, 35 kD subunit GO:0006206//GO:0006144//GO:0008283//GO:0040007//GO:0006351//GO:0015992//GO:0042967//GO:0006123//GO:0007165//GO:0019083 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//cell proliferation//growth//transcription, DNA-templated//proton transport//acyl-carrier-protein biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//viral transcription GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0008083//GO:0003677//GO:0003899 cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//growth factor activity//DNA binding//DNA-directed RNA polymerase activity GO:0005576//GO:0016020//GO:0019031//GO:0045277//GO:0005634//GO:0005730//GO:0005739 extracellular region//membrane//viral envelope//respiratory chain complex IV//nucleus//nucleolus//mitochondrion KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.39159 BF_2 66.33 0.44 6577 91091096 XP_968472.1 1886 8.6e-208 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58428 301 2.2e-25 ATP-binding cassette sub-family G member 8 OS=Rattus norvegicus GN=Abcg8 PE=2 SV=2 PF05297//PF00005//PF01061 Herpesvirus latent membrane protein 1 (LMP1)//ABC transporter//ABC-2 type transporter GO:0006200//GO:0019087 obsolete ATP catabolic process//transformation of host cell by virus GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.3916 BF_2 2.00 0.75 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39160 BF_2 1628.79 9.88 7186 642934549 XP_008197710.1 1789 1.7e-196 PREDICTED: axoneme-associated protein mst101(2)-like isoform X2 [Tribolium castaneum] 768421079 XM_011553033.1 246 5.81483e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 1470 6.7e-161 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00433//PF07714//PF00069//PF00858 Protein kinase C terminal domain//Protein tyrosine kinase//Protein kinase domain//Amiloride-sensitive sodium channel GO:0006814//GO:0009069//GO:0006468//GO:0016310 sodium ion transport//serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005272//GO:0004672//GO:0004674//GO:0005524 sodium channel activity//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.39161 BF_2 378.00 3.45 4864 270012858 EFA09306.1 375 1.0e-32 hypothetical protein TcasGA2_TC030618, partial [Tribolium castaneum] -- -- -- -- -- K07928 RAB40 Ras-related protein Rab-40 http://www.genome.jp/dbget-bin/www_bget?ko:K07928 Q8VHP8 151 4.0e-08 Ras-related protein Rab-40B OS=Mus musculus GN=Rab40b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39163 BF_2 10.92 0.58 1072 91088775 XP_967272.1 981 1.2e-103 PREDICTED: peptide methionine sulfoxide reductase [Tribolium castaneum]>gi|270011632|gb|EFA08080.1| hypothetical protein TcasGA2_TC005676 [Tribolium castaneum] -- -- -- -- -- K07304 msrA peptide-methionine (S)-S-oxide reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07304 P08761 610 5.3e-62 Peptide methionine sulfoxide reductase OS=Drosophila melanogaster GN=Eip71CD PE=2 SV=2 PF01625 Peptide methionine sulfoxide reductase GO:0055114//GO:0006464 oxidation-reduction process//cellular protein modification process GO:0008113 peptide-methionine (S)-S-oxide reductase activity -- -- KOG1635 Peptide methionine sulfoxide reductase Cluster-8309.39166 BF_2 858.00 75.27 764 -- -- -- -- -- 642918450 XM_965626.3 51 1.49254e-15 PREDICTED: Tribolium castaneum paramyosin, long form (LOC659309), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39168 BF_2 64.28 1.08 2783 642926864 XP_008195044.1 2266 3.2e-252 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum] 748585115 LC002996.1 39 2.62998e-08 Ostrinia furnacalis gene for hypothetical protein, partial cds, note: entry16 -- -- -- -- O18824 615 3.6e-62 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.39170 BF_2 1999.60 31.26 2963 91084727 XP_970450.1 2622 1.8e-293 PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|642925824|ref|XP_008190453.1| PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|270008937|gb|EFA05385.1| hypothetical protein TcasGA2_TC015557 [Tribolium castaneum] 642925825 XM_965357.2 476 0 PREDICTED: Tribolium castaneum uncharacterized LOC659018 (LOC659018), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF01749 Importin beta binding domain GO:0015031//GO:0006606 protein transport//protein import into nucleus GO:0008565 protein transporter activity GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.39171 BF_2 1031.00 56.61 1049 270004120 EFA00568.1 1253 3.5e-135 hypothetical protein TcasGA2_TC003438 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 1047 1.1e-112 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.39172 BF_2 1883.09 144.32 833 270297202 NP_001161902.1 1021 2.2e-108 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 771 8.8e-81 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.39174 BF_2 180.18 1.62 4952 642939101 XP_008200222.1 1724 4.0e-189 PREDICTED: uncharacterized protein LOC658083 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 1226 9.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.39175 BF_2 18.92 0.38 2373 332374674 AEE62478.1 1301 2.1e-140 unknown [Dendroctonus ponderosae]>gi|478260316|gb|ENN80068.1| hypothetical protein YQE_03544, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BNA9 1005 1.8e-107 CCR4-NOT transcription complex subunit 11 OS=Rattus norvegicus GN=Cnot11 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39176 BF_2 935.84 15.78 2768 546676385 ERL87407.1 403 3.3e-36 hypothetical protein D910_04802 [Dendroctonus ponderosae] 755959155 XM_011306001.1 66 2.56069e-23 PREDICTED: Fopius arisanus 60S ribosomal protein L38 (LOC105267271), mRNA K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q4GX86 339 3.6e-30 60S ribosomal protein L38 OS=Timarcha balearica GN=RpL38 PE=3 SV=1 PF11857//PF00106//PF01781 Domain of unknown function (DUF3377)//short chain dehydrogenase//Ribosomal L38e protein family GO:0042254//GO:0006412//GO:0008152 ribosome biogenesis//translation//metabolic process GO:0003735//GO:0016491//GO:0004222 structural constituent of ribosome//oxidoreductase activity//metalloendopeptidase activity GO:0005622//GO:0005840 intracellular//ribosome KOG3499 60S ribosomal protein L38 Cluster-8309.39177 BF_2 676.75 7.22 4207 642924614 XP_008194364.1 1951 1.6e-215 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.8e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0003700 DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39178 BF_2 325.88 7.24 2170 642929065 XP_008195677.1 2246 5.1e-250 PREDICTED: CCR4-NOT transcription complex subunit 10 [Tribolium castaneum]>gi|642929067|ref|XP_008195678.1| PREDICTED: CCR4-NOT transcription complex subunit 10 [Tribolium castaneum] -- -- -- -- -- K12607 CNOT10 CCR4-NOT transcription complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K12607 Q5ZIW2 768 5.1e-80 CCR4-NOT transcription complex subunit 10 OS=Gallus gallus GN=CNOT10 PE=2 SV=1 PF13176//PF08054//PF13414//PF13181//PF00515//PF13374//PF01335 Tetratricopeptide repeat//Leucine operon leader peptide//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Death effector domain GO:0009098//GO:0042981 leucine biosynthetic process//regulation of apoptotic process GO:0005515 protein binding -- -- -- -- Cluster-8309.39179 BF_2 100.03 0.63 6895 642929799 XP_008195982.1 2636 9.8e-295 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 2-like [Tribolium castaneum] 118150627 NM_001077805.1 77 4.93255e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1299 4.3e-141 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF00413//PF10462//PF01562//PF05093//PF01421 Matrixin//Peptidase M66//Reprolysin family propeptide//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Reprolysin (M12B) family zinc metalloprotease GO:0016226//GO:0006508 iron-sulfur cluster assembly//proteolysis GO:0051536//GO:0008270//GO:0004222 iron-sulfur cluster binding//zinc ion binding//metalloendopeptidase activity GO:0005737//GO:0031012 cytoplasm//extracellular matrix KOG2210 Oxysterol-binding protein Cluster-8309.39181 BF_2 41.05 0.33 5561 546678097 ERL88806.1 2073 1.5e-229 hypothetical protein D910_06188 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.39182 BF_2 18.19 0.62 1512 91076454 XP_971838.1 304 5.5e-25 PREDICTED: ubiquitin-like protein FUBI [Tribolium castaneum]>gi|270002576|gb|EEZ99023.1| hypothetical protein TcasGA2_TC004892 [Tribolium castaneum] -- -- -- -- -- K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 Q9W6Y0 138 4.0e-07 40S ribosomal protein S30 OS=Oryzias latipes GN=fau PE=3 SV=2 PF00240//PF04758 Ubiquitin family//Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.39185 BF_2 4809.24 24.92 8359 642926040 XP_008194740.1 10492 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 1035 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 7605 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF08326//PF02655//PF07478//PF02786 Acetyl-CoA carboxylase, central region//ATP-grasp domain//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain GO:0046436//GO:0006633//GO:0009252//GO:0006090 D-alanine metabolic process//fatty acid biosynthetic process//peptidoglycan biosynthetic process//pyruvate metabolic process GO:0005524//GO:0046872//GO:0003989//GO:0008716 ATP binding//metal ion binding//acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.39186 BF_2 0.43 0.41 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39187 BF_2 25.43 0.35 3310 642923827 XP_008193896.1 1230 5.1e-132 PREDICTED: endonuclease/exonuclease/phosphatase family domain-containing protein 1-like [Tribolium castaneum]>gi|270007767|gb|EFA04215.1| hypothetical protein TcasGA2_TC014464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IND4 330 4.8e-29 Endonuclease/exonuclease/phosphatase family domain-containing protein 1 OS=Xenopus laevis GN=eepd1 PE=2 SV=1 PF03934//PF00633 Type II secretion system (T2SS), protein K//Helix-hairpin-helix motif GO:0009306//GO:0006281 protein secretion//DNA repair GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.39188 BF_2 2886.83 67.77 2069 642939193 XP_008200375.1 661 3.0e-66 PREDICTED: cytochrome c oxidase subunit 5A, mitochondrial [Tribolium castaneum]>gi|270016379|gb|EFA12825.1| hypothetical protein TcasGA2_TC001862 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 8.4e-40 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0045277 mitochondrial inner membrane//respiratory chain complex IV KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.39189 BF_2 128.41 2.98 2092 642939193 XP_008200375.1 661 3.1e-66 PREDICTED: cytochrome c oxidase subunit 5A, mitochondrial [Tribolium castaneum]>gi|270016379|gb|EFA12825.1| hypothetical protein TcasGA2_TC001862 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 8.5e-40 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005743//GO:0045277 mitochondrial inner membrane//respiratory chain complex IV KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.39190 BF_2 101.33 1.08 4211 91079776 XP_967502.1 1323 1.1e-142 PREDICTED: coiled-coil domain-containing protein 50 [Tribolium castaneum]>gi|270004516|gb|EFA00964.1| hypothetical protein TcasGA2_TC003874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IVM0 183 6.8e-12 Coiled-coil domain-containing protein 50 OS=Homo sapiens GN=CCDC50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39193 BF_2 1534.34 14.94 4583 332373726 AEE62004.1 428 7.0e-39 unknown [Dendroctonus ponderosae]>gi|478250918|gb|ENN71403.1| hypothetical protein YQE_11907, partial [Dendroctonus ponderosae]>gi|546684873|gb|ERL94455.1| hypothetical protein D910_11732 [Dendroctonus ponderosae] -- -- -- -- -- K03873 TCEB2 transcription elongation factor B, polypeptide 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03873 P62870 254 4.3e-20 Transcription elongation factor B polypeptide 2 OS=Rattus norvegicus GN=Tceb2 PE=1 SV=1 PF05920//PF00240//PF14560//PF00046 Homeobox KN domain//Ubiquitin family//Ubiquitin-like domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0483 Transcription factor HEX, contains HOX and HALZ domains Cluster-8309.39195 BF_2 1068.10 5.31 8704 270007741 EFA04189.1 2015 1.3e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 5.56652e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 878 3.6e-92 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF05121//PF01426//PF02845//PF07776//PF00641//PF09182 Gas vesicle protein K//BAH domain//CUE domain//Zinc-finger associated domain (zf-AD)//Zn-finger in Ran binding protein and others//Bacterial purine repressor, N-terminal GO:0031412//GO:0006355 gas vesicle organization//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0003682//GO:0008270 protein binding//DNA binding//chromatin binding//zinc ion binding GO:0000785//GO:0005634 chromatin//nucleus KOG1812 Predicted E3 ubiquitin ligase Cluster-8309.39196 BF_2 190.31 4.28 2147 642916373 XP_008190993.1 951 7.4e-100 PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum]>gi|642916375|ref|XP_008190995.1| PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q6P6R0 539 1.8e-53 Protein lifeguard 1 OS=Rattus norvegicus GN=Grina PE=2 SV=1 PF05393 Human adenovirus early E3A glycoprotein -- -- -- -- GO:0016021 integral component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.39197 BF_2 1.00 0.66 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39198 BF_2 35.65 0.68 2472 642931392 XP_008196559.1 1015 3.2e-107 PREDICTED: paramyosin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39199 BF_2 385.24 7.43 2457 642931392 XP_008196559.1 1015 3.2e-107 PREDICTED: paramyosin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39200 BF_2 514.75 12.28 2040 478255100 ENN75330.1 2419 4.2e-270 hypothetical protein YQE_08107, partial [Dendroctonus ponderosae] -- -- -- -- -- K01890 FARSB, pheT phenylalanyl-tRNA synthetase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01890 Q9VCA5 2049 1.4e-228 Phenylalanine--tRNA ligase beta subunit OS=Drosophila melanogaster GN=beta-PheRS PE=1 SV=1 PF03483//PF02531//PF03484 B3/4 domain//PsaD//tRNA synthetase B5 domain GO:0015979//GO:0006432//GO:0009094//GO:0006571//GO:0000162 photosynthesis//phenylalanyl-tRNA aminoacylation//L-phenylalanine biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0003723//GO:0005524//GO:0004826//GO:0000287 RNA binding//ATP binding//phenylalanine-tRNA ligase activity//magnesium ion binding GO:0009522//GO:0009538//GO:0009328 photosystem I//photosystem I reaction center//phenylalanine-tRNA ligase complex KOG2472 Phenylalanyl-tRNA synthetase beta subunit Cluster-8309.39201 BF_2 10345.98 970.73 733 -- -- -- -- -- 209571502 NM_001135910.1 85 1.79715e-34 Tribolium castaneum ribosomal protein L41 (Rpl41), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39203 BF_2 558.32 12.56 2147 195356716 XP_002044796.1 166 7.9e-09 GM13286 [Drosophila sechellia]>gi|194121629|gb|EDW43672.1| GM13286 [Drosophila sechellia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39204 BF_2 346.99 4.39 3593 91078712 XP_966534.1 1635 6.0e-179 PREDICTED: ethanolamine-phosphate cytidylyltransferase [Tribolium castaneum]>gi|270003752|gb|EFA00200.1| hypothetical protein TcasGA2_TC003025 [Tribolium castaneum] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 1228 3.9e-133 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF01467//PF00154//PF06574//PF02569 Cytidylyltransferase-like//recA bacterial DNA recombination protein//FAD synthetase//Pantoate-beta-alanine ligase GO:0009432//GO:0006771//GO:0019482//GO:0009058//GO:0015940//GO:0006281//GO:0009231 SOS response//riboflavin metabolic process//beta-alanine metabolic process//biosynthetic process//pantothenate biosynthetic process//DNA repair//riboflavin biosynthetic process GO:0004592//GO:0016779//GO:0003919//GO:0005524//GO:0003824//GO:0003697 pantoate-beta-alanine ligase activity//nucleotidyltransferase activity//FMN adenylyltransferase activity//ATP binding//catalytic activity//single-stranded DNA binding -- -- KOG2803 Choline phosphate cytidylyltransferase/Predicted CDP-ethanolamine synthase Cluster-8309.39206 BF_2 24.32 0.74 1654 91094771 XP_967866.1 1686 3.4e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.3e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.39207 BF_2 42.21 0.60 3221 642925753 XP_008201610.1 672 2.5e-67 PREDICTED: protein GUCD1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 1.3e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284 Cytochrome c oxidase subunit Va GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.39208 BF_2 395.08 25.51 935 642932529 XP_008197152.1 450 4.0e-42 PREDICTED: type-1 angiotensin II receptor-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39209 BF_2 27.47 0.78 1762 546683303 ERL93135.1 558 2.3e-54 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 370 5.9e-34 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39211 BF_2 131.38 0.66 8575 642913474 XP_008201027.1 774 9.9e-79 PREDICTED: uncharacterized protein LOC664262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 531 6.1e-52 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39213 BF_2 195.13 1.18 7197 91090606 XP_973086.1 645 7.6e-64 PREDICTED: peroxisomal membrane protein PEX14 [Tribolium castaneum] -- -- -- -- -- K13343 PEX14 peroxin-14 http://www.genome.jp/dbget-bin/www_bget?ko:K13343 Q642G4 224 2.0e-16 Peroxisomal membrane protein PEX14 OS=Rattus norvegicus GN=Pex14 PE=1 SV=1 PF05008 Vesicle transport v-SNARE protein N-terminus GO:0006886 intracellular protein transport -- -- GO:0016020 membrane KOG2629 Peroxisomal membrane anchor protein (peroxin) Cluster-8309.39214 BF_2 310.83 1.34 10007 642916148 XP_008190905.1 3559 0.0e+00 PREDICTED: BAI1-associated protein 3 [Tribolium castaneum]>gi|270003708|gb|EFA00156.1| hypothetical protein TcasGA2_TC002977 [Tribolium castaneum] 642916147 XM_008192683.1 676 0 PREDICTED: Tribolium castaneum BAI1-associated protein 3 (LOC661754), mRNA K15621 BAIAP3 BAI1-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15621 O94812 905 3.1e-95 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF00168//PF06070//PF01779 C2 domain//Herpesvirus large structural phosphoprotein UL32//Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0005515//GO:0005198//GO:0003735 protein binding//structural molecule activity//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.39215 BF_2 12.64 0.82 931 189235871 XP_001811450.1 243 4.0e-18 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39216 BF_2 17.04 0.39 2120 478255545 ENN75762.1 1819 1.6e-200 hypothetical protein YQE_07721, partial [Dendroctonus ponderosae] 665793581 XM_008546222.1 67 5.43528e-24 PREDICTED: Microplitis demolitor proton-associated sugar transporter A-like (LOC103569108), mRNA K15378 SLC45A1_2_4 solute carrier family 45, member 1/2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15378 Q9UMX9 636 1.0e-64 Membrane-associated transporter protein OS=Homo sapiens GN=SLC45A2 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0637 Sucrose transporter and related proteins Cluster-8309.39217 BF_2 237.16 2.35 4501 642934019 XP_008197606.1 1061 2.7e-112 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 192 3.79039e-93 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9JMD3 495 4.8e-48 PCTP-like protein OS=Mus musculus GN=Stard10 PE=1 SV=1 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.39223 BF_2 379.00 8.19 2224 91094635 XP_970093.1 1672 1.9e-183 PREDICTED: replication protein A 70 kDa DNA-binding subunit [Tribolium castaneum]>gi|270016445|gb|EFA12891.1| hypothetical protein TcasGA2_TC004405 [Tribolium castaneum] -- -- -- -- -- K07466 RFA1, RPA1, rpa replication factor A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07466 Q24492 1460 3.0e-160 Replication protein A 70 kDa DNA-binding subunit OS=Drosophila melanogaster GN=RpA-70 PE=1 SV=1 PF01428//PF04057//PF01336 AN1-like Zinc finger//Replication factor-A protein 1, N-terminal domain//OB-fold nucleic acid binding domain GO:0006260 DNA replication GO:0003677//GO:0003676//GO:0008270 DNA binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus KOG0851 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins Cluster-8309.39224 BF_2 309.00 12.02 1363 501296187 BAN20955.1 413 1.1e-37 conserved hypothetical protein [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q9VBV3 156 3.0e-09 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 PF00129//PF05379 Class I Histocompatibility antigen, domains alpha 1 and 2//Carlavirus endopeptidase GO:0006144//GO:0006955 purine nucleobase metabolic process//immune response GO:0016817//GO:0003968 hydrolase activity, acting on acid anhydrides//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.39225 BF_2 202.94 4.05 2381 291170322 ADD82417.1 210 6.9e-14 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27017 155 6.8e-09 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.39226 BF_2 183.69 1.67 4882 642934681 XP_008197767.1 4375 0.0e+00 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X5 [Tribolium castaneum] 642934684 XM_008199547.1 110 1.57687e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1560 1.7e-171 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0016114//GO:0009190 intracellular signal transduction//terpenoid biosynthetic process//cyclic nucleotide biosynthetic process GO:0008685//GO:0016849 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity//phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.39227 BF_2 523.62 4.39 5278 557777952 XP_005188609.1 1007 5.8e-106 PREDICTED: 4-coumarate--CoA ligase 1 [Musca domestica] -- -- -- -- -- -- -- -- -- Q27757 859 3.5e-90 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF03283//PF00501//PF05924 Pectinacetylesterase//AMP-binding enzyme//SAMP Motif GO:0008152//GO:0016055 metabolic process//Wnt signaling pathway GO:0003824//GO:0008013//GO:0016787 catalytic activity//beta-catenin binding//hydrolase activity GO:0016342 catenin complex KOG1176 Acyl-CoA synthetase Cluster-8309.39228 BF_2 1264.38 26.26 2301 270016491 EFA12937.1 319 1.5e-26 hypothetical protein TcasGA2_TC010484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CUX1 178 1.4e-11 52 kDa repressor of the inhibitor of the protein kinase OS=Mus musculus GN=Prkrir PE=2 SV=2 PF03854 P-11 zinc finger -- -- GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- -- -- Cluster-8309.39229 BF_2 178.37 1.15 6781 91083759 XP_971689.1 2098 2.3e-232 PREDICTED: translocation protein SEC63 homolog [Tribolium castaneum] 241591921 XM_002403988.1 183 5.7639e-88 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 1436 5.6e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF06414//PF05470//PF00973//PF01591 Zeta toxin//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Paramyxovirus nucleocapsid protein//6-phosphofructo-2-kinase GO:0006413//GO:0006013//GO:0006000//GO:0006446 translational initiation//mannose metabolic process//fructose metabolic process//regulation of translational initiation GO:0031369//GO:0016301//GO:0005524//GO:0003743//GO:0003873//GO:0005198 translation initiation factor binding//kinase activity//ATP binding//translation initiation factor activity//6-phosphofructo-2-kinase activity//structural molecule activity GO:0005840//GO:0005852//GO:0019013 ribosome//eukaryotic translation initiation factor 3 complex//viral nucleocapsid KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.39231 BF_2 141.93 1.31 4833 283046738 NP_001164316.1 941 2.4e-98 TAK1-associated binding protein 2 isoform A [Tribolium castaneum]>gi|270012754|gb|EFA09202.1| Tab2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99K90 180 1.7e-11 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 OS=Mus musculus GN=Tab2 PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.39236 BF_2 3.03 0.57 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.39237 BF_2 131.15 7.21 1048 255522805 NP_001157315.1 721 1.7e-73 longitudinals lacking isoform 6 [Tribolium castaneum] 255522808 NM_001163845.1 254 2.94824e-128 Tribolium castaneum longitudinals lacking (Lola), transcript variant 8, mRNA -- -- -- -- -- -- -- -- PF16622//PF00643//PF13912//PF01785//PF13465//PF02701//PF00096 zinc-finger C2H2-type//B-box zinc finger//C2H2-type zinc finger//Closterovirus coat protein//Zinc-finger double domain//Dof domain, zinc finger//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0019012//GO:0005622 virion//intracellular KOG1721 FOG: Zn-finger Cluster-8309.39238 BF_2 70.00 6.44 742 13625795 AAK35160.1 312 3.2e-26 defensin 1 precursor [Acalolepta luxuriosa] -- -- -- -- -- -- -- -- -- Q27023 225 1.6e-17 Tenecin-1 OS=Tenebrio molitor PE=1 SV=1 PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-8309.39244 BF_2 1662.00 20.29 3713 189234829 XP_001811696.1 2830 0.0e+00 PREDICTED: protein fem-1 homolog CG6966 isoform X1 [Tribolium castaneum]>gi|270001481|gb|EEZ97928.1| hypothetical protein TcasGA2_TC000315 [Tribolium castaneum] 751210065 XM_011159411.1 167 2.46479e-79 PREDICTED: Solenopsis invicta protein fem-1 homolog CG6966 (LOC105194484), transcript variant X1, mRNA -- -- -- -- Q9VFD5 1761 6.3e-195 Protein fem-1 homolog CG6966 OS=Drosophila melanogaster GN=CG6966 PE=2 SV=2 PF00023//PF13606//PF13374 Ankyrin repeat//Ankyrin repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.39245 BF_2 788.15 49.74 950 546683453 ERL93259.1 1219 2.7e-131 hypothetical protein D910_10555 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 258 3.1e-21 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF16656//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.39250 BF_2 3986.62 8.64 19593 642937892 XP_008200345.1 18830 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 3.5658e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 10409 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF01667//PF03488//PF02806//PF04410//PF03875//PF02207 Ribosomal protein S27//Nematode insulin-related peptide beta type//Alpha amylase, C-terminal all-beta domain//Gar1/Naf1 RNA binding region//Statherin//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0030500//GO:0007165//GO:0042742//GO:0042254//GO:0001522//GO:0005975 translation//regulation of bone mineralization//signal transduction//defense response to bacterium//ribosome biogenesis//pseudouridine synthesis//carbohydrate metabolic process GO:0005179//GO:0003824//GO:0043169//GO:0046848//GO:0008270//GO:0003735 hormone activity//catalytic activity//cation binding//hydroxyapatite binding//zinc ion binding//structural constituent of ribosome GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1776 Zn-binding protein Push Cluster-8309.39251 BF_2 474.59 3.62 5772 270004122 EFA00570.1 298 1.0e-23 hypothetical protein TcasGA2_TC003440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.39252 BF_2 1567.98 6.09 11065 642934315 XP_008198597.1 2307 2.2e-256 PREDICTED: integrin alpha-PS2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 1766 4.9e-195 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF05375//PF15686 Pacifastin inhibitor (LCMII)//Lysine-rich CEACAM1 co-isolated protein family GO:0045766//GO:0043066//GO:0043123 positive regulation of angiogenesis//negative regulation of apoptotic process//positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.39253 BF_2 332.00 4.21 3588 478258188 ENN78320.1 229 6.5e-16 hypothetical protein YQE_05211, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39254 BF_2 3668.37 49.31 3399 270016569 EFA13015.1 3551 0.0e+00 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] 831318133 XM_012836335.1 35 5.38777e-06 PREDICTED: Clupea harengus low density lipoprotein receptor-related protein 2 (lrp2), mRNA -- -- -- -- P98165 1668 3.5e-184 Very low-density lipoprotein receptor OS=Gallus gallus GN=VLDLR PE=1 SV=1 PF08506//PF00002//PF00057//PF07645 Cse1//7 transmembrane receptor (Secretin family)//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain GO:0006886//GO:0007186 intracellular protein transport//G-protein coupled receptor signaling pathway GO:0005515//GO:0005509//GO:0004930 protein binding//calcium ion binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.39255 BF_2 3521.42 26.82 5780 546682882 ERL92768.1 2101 8.9e-233 hypothetical protein D910_10076 [Dendroctonus ponderosae] -- -- -- -- -- K17785 IMMT, FCJ1, MNOS2 mitofilin http://www.genome.jp/dbget-bin/www_bget?ko:K17785 P91928 1217 1.2e-131 MICOS complex subunit Mic60 OS=Drosophila melanogaster GN=Mitofilin PE=1 SV=4 PF01557//PF01632//PF09074 Fumarylacetoacetate (FAA) hydrolase family//Ribosomal protein L35//Mer2 GO:0008152//GO:0006412//GO:0007131//GO:0042254 metabolic process//translation//reciprocal meiotic recombination//ribosome biogenesis GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0000794//GO:0005840//GO:0005622 condensed nuclear chromosome//ribosome//intracellular KOG1854 Mitochondrial inner membrane protein (mitofilin) Cluster-8309.39256 BF_2 586.78 10.30 2670 91078460 XP_967570.1 1377 3.7e-149 PREDICTED: tether containing UBX domain for GLUT4-like [Tribolium castaneum] -- -- -- -- -- K15627 ASPSCR1, ASPL tether containing UBX domain for GLUT4 http://www.genome.jp/dbget-bin/www_bget?ko:K15627 Q9BZE9 550 1.2e-54 Tether containing UBX domain for GLUT4 OS=Homo sapiens GN=ASPSCR1 PE=1 SV=1 PF02196//PF00789 Raf-like Ras-binding domain//UBX domain GO:0007165 signal transduction GO:0005057//GO:0005515 receptor signaling protein activity//protein binding -- -- KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.39258 BF_2 867.65 4.77 7889 642918117 XP_008194070.1 5241 0.0e+00 PREDICTED: ALK tyrosine kinase receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 1482 3.0e-162 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF00629//PF00069//PF07714//PF00057 MAM domain, meprin/A5/mu//Protein kinase domain//Protein tyrosine kinase//Low-density lipoprotein receptor domain class A GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity GO:0016020 membrane KOG1095 Protein tyrosine kinase Cluster-8309.39259 BF_2 552.93 2.27 10459 91084143 XP_970053.1 9179 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X2 [Tribolium castaneum]>gi|270006644|gb|EFA03092.1| hypothetical protein TcasGA2_TC013000 [Tribolium castaneum] 642925099 XM_964960.2 1383 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9LV03 5399 0.0e+00 Glutamate synthase 1 [NADH], chloroplastic OS=Arabidopsis thaliana GN=GLT1 PE=2 SV=2 PF04898//PF01070//PF00743//PF01593//PF12831//PF01645//PF04183//PF01266//PF01493//PF01210//PF00070//PF01494//PF00287//PF07992//PF00833//PF05834//PF13241//PF01134//PF00869 Glutamate synthase central domain//FMN-dependent dehydrogenase//Flavin-binding monooxygenase-like//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Conserved region in glutamate synthase//IucA / IucC family//FAD dependent oxidoreductase//GXGXG motif//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Sodium / potassium ATPase beta chain//Pyridine nucleotide-disulphide oxidoreductase//Ribosomal S17//Lycopene cyclase protein//Putative NAD(P)-binding//Glucose inhibited division protein A//Flavivirus glycoprotein, central and dimerisation domains GO:0006813//GO:0006412//GO:0006807//GO:0006537//GO:0006826//GO:0008033//GO:0008152//GO:0019354//GO:0046168//GO:0016117//GO:0019290//GO:0006118//GO:0006814//GO:0042254//GO:0055114//GO:0006779 potassium ion transport//translation//nitrogen compound metabolic process//glutamate biosynthetic process//iron ion transport//tRNA processing//metabolic process//siroheme biosynthetic process//glycerol-3-phosphate catabolic process//carotenoid biosynthetic process//siderophore biosynthetic process//obsolete electron transport//sodium ion transport//ribosome biogenesis//oxidation-reduction process//porphyrin-containing compound biosynthetic process GO:0016705//GO:0004499//GO:0050661//GO:0051287//GO:0016040//GO:0050660//GO:0071949//GO:0051536//GO:0015343//GO:0016638//GO:0043115//GO:0046983//GO:0016491//GO:0015930//GO:0010181//GO:0016616//GO:0003735//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//N,N-dimethylaniline monooxygenase activity//NADP binding//NAD binding//glutamate synthase (NADH) activity//flavin adenine dinucleotide binding//FAD binding//iron-sulfur cluster binding//siderophore transmembrane transporter activity//oxidoreductase activity, acting on the CH-NH2 group of donors//precorrin-2 dehydrogenase activity//protein dimerization activity//oxidoreductase activity//glutamate synthase activity//FMN binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//iron ion binding GO:0005840//GO:0005622//GO:0005890 ribosome//intracellular//sodium:potassium-exchanging ATPase complex KOG0399 Glutamate synthase Cluster-8309.39260 BF_2 72.11 0.63 5072 478250378 ENN70873.1 238 8.3e-17 hypothetical protein YQE_12278, partial [Dendroctonus ponderosae]>gi|546672870|gb|ERL84593.1| hypothetical protein D910_02021 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 135 3.0e-06 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane KOG1304 Amino acid transporters Cluster-8309.39261 BF_2 54.76 0.49 4936 642935897 XP_008198219.1 1075 7.1e-114 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X2 [Tribolium castaneum] 688627348 LL261331.1 74 1.6402e-27 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q8NA58 360 2.4e-32 Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.39262 BF_2 762.85 5.41 6191 642930820 XP_008196102.1 3934 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.26658e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q6GPD0 1258 2.2e-136 Rho GTPase-activating protein 32 OS=Xenopus laevis GN=arhgap32 PE=2 SV=1 PF01929//PF14604//PF00018//PF00620//PF00787 Ribosomal protein L14//Variant SH3 domain//SH3 domain//RhoGAP domain//PX domain GO:0042254//GO:0007154//GO:0006412//GO:0007165 ribosome biogenesis//cell communication//translation//signal transduction GO:0003735//GO:0005515//GO:0035091 structural constituent of ribosome//protein binding//phosphatidylinositol binding GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.39263 BF_2 247.64 15.89 939 728418014 AIY68354.1 746 1.9e-76 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39264 BF_2 3070.36 106.60 1492 662193280 XP_008469540.1 1298 3.0e-140 PREDICTED: succinyl-CoA ligase subunit alpha, mitochondrial [Diaphorina citri] 754347720 XM_004347817.2 102 1.32795e-43 Capsaspora owczarzaki ATCC 30864 succinate-CoA ligase mRNA K01899 LSC1 succinyl-CoA synthetase alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01899 Q94522 1186 1.2e-128 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial OS=Drosophila melanogaster GN=Scsalpha PE=2 SV=3 PF00549//PF02629//PF13380 CoA-ligase//CoA binding domain//CoA binding domain GO:0008152 metabolic process GO:0003824//GO:0048037 catalytic activity//cofactor binding -- -- KOG1255 Succinyl-CoA synthetase, alpha subunit Cluster-8309.39265 BF_2 2563.57 22.21 5115 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 1.00172e-39 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 2.2e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF08534//PF01496//PF00578//PF03099//PF10417 Redoxin//V-type ATPase 116kDa subunit family//AhpC/TSA family//Biotin/lipoate A/B protein ligase family//C-terminal domain of 1-Cys peroxiredoxin GO:0015991//GO:0006464//GO:0055114//GO:0015992 ATP hydrolysis coupled proton transport//cellular protein modification process//oxidation-reduction process//proton transport GO:0016491//GO:0051920//GO:0015078//GO:0016209 oxidoreductase activity//peroxiredoxin activity//hydrogen ion transmembrane transporter activity//antioxidant activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.39266 BF_2 160.07 2.95 2559 728417098 AIY68333.1 930 2.4e-97 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 555 3.0e-55 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.39267 BF_2 197.00 4.33 2189 571032311 AHF21588.1 1701 8.1e-187 cytochrome oxidase c subunit 1 (mitochondrion) [Allothyrus sp. LamingtonNP-QMS95173] 544190472 KF197117.1 672 0 Ixodes ricinus isolate IR_8 mitochondrion, complete genome K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 O99818 1610 1.2e-177 Cytochrome c oxidase subunit 1 OS=Rhipicephalus sanguineus GN=COI PE=3 SV=1 PF00115 Cytochrome C and Quinol oxidase polypeptide I GO:0015992//GO:0055114//GO:0006118//GO:0009060//GO:0006123 proton transport//oxidation-reduction process//obsolete electron transport//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen GO:0005506//GO:0004129//GO:0020037//GO:0009055 iron ion binding//cytochrome-c oxidase activity//heme binding//electron carrier activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG4769 Cytochrome c oxidase, subunit I Cluster-8309.39268 BF_2 451.85 7.07 2959 642917848 XP_008191311.1 874 8.7e-91 PREDICTED: serine/threonine-protein kinase MARK2 isoform X9 [Tribolium castaneum] 602660707 XM_007435954.1 79 1.62572e-30 PREDICTED: Python bivittatus MAP/microtubule affinity-regulating kinase 1 (MARK1), transcript variant X5, mRNA K08798 MARK MAP/microtubule affinity-regulating kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08798 O08678 506 1.7e-49 Serine/threonine-protein kinase MARK1 OS=Rattus norvegicus GN=Mark1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0586 Serine/threonine protein kinase Cluster-8309.3927 BF_2 4.00 0.46 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39270 BF_2 66.58 3.57 1067 642910841 XP_008193430.1 271 2.6e-21 PREDICTED: bolA-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CEI1 196 5.3e-14 BolA-like protein 3 OS=Mus musculus GN=Bola3 PE=3 SV=1 PF02445 Quinolinate synthetase A protein GO:0009435 NAD biosynthetic process GO:0008987//GO:0051539 quinolinate synthetase A activity//4 iron, 4 sulfur cluster binding GO:0019804 obsolete quinolinate synthetase complex KOG3348 BolA (bacterial stress-induced morphogen)-related protein Cluster-8309.39271 BF_2 9.09 0.38 1299 642919915 XP_008192123.1 1014 2.2e-107 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9K8 222 6.3e-17 Caskin-1 OS=Mus musculus GN=Caskin1 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0507 CASK-interacting adaptor protein (caskin) and related proteins with ankyrin repeats and SAM domain Cluster-8309.39272 BF_2 16.70 0.43 1923 91076308 XP_969307.1 2263 4.9e-252 PREDICTED: furin-like protease 2 [Tribolium castaneum] 817211511 XM_012426473.1 448 0 PREDICTED: Orussus abietinus furin-like protease 2 (LOC105700544), mRNA K08672 PCSK6 proprotein convertase subtilisin/kexin type 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08672 P30432 2002 3.7e-223 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3525 Subtilisin-like proprotein convertase Cluster-8309.39274 BF_2 6.00 4.33 339 546685745 ERL95200.1 333 5.4e-29 hypothetical protein D910_12468 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39275 BF_2 8.94 0.61 896 478258777 ENN78800.1 258 7.0e-20 hypothetical protein YQE_04737, partial [Dendroctonus ponderosae]>gi|546678780|gb|ERL89332.1| hypothetical protein D910_06704 [Dendroctonus ponderosae] 42764849 AY439820.1 48 8.19977e-14 Armigeres subalbatus ASAP ID: 40029 barrier-to-autointegration factor mRNA sequence -- -- -- -- Q9VLU0 217 1.6e-16 Barrier-to-autointegration factor OS=Drosophila melanogaster GN=baf PE=3 SV=1 PF02961 Barrier to autointegration factor -- -- GO:0003677 DNA binding -- -- KOG4233 DNA-bridging protein BAF Cluster-8309.39276 BF_2 1332.22 26.30 2406 642936150 XP_975125.2 902 4.0e-94 PREDICTED: zinc transporter ZIP13 homolog [Tribolium castaneum] -- -- -- -- -- K14719 SLC39A13, ZIP13 solute carrier family 39 (zinc transporter), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14719 Q9VAF0 557 1.7e-55 Zinc transporter ZIP13 homolog OS=Drosophila melanogaster GN=Zip99C PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.39278 BF_2 386.21 30.78 812 546681806 ERL91832.1 591 1.6e-58 hypothetical protein D910_09157 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379//PF03938 Insect cuticle protein//Outer membrane protein (OmpH-like) -- -- GO:0042302//GO:0051082 structural constituent of cuticle//unfolded protein binding -- -- -- -- Cluster-8309.39279 BF_2 1035.36 4.83 9259 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.46655e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF01133//PF05384//PF00874//PF10440//PF05007//PF00089//PF03554 Enhancer of rudimentary//Sensor protein DegS//PRD domain//Ubiquitin-binding WIYLD domain//Mannosyltransferase (PIG-M)//Trypsin//UL73 viral envelope glycoprotein GO:0007165//GO:0006221//GO:0045747//GO:0007049//GO:0006554//GO:0006355//GO:0006479//GO:0006506//GO:0006508 signal transduction//pyrimidine nucleotide biosynthetic process//positive regulation of Notch signaling pathway//cell cycle//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation//GPI anchor biosynthetic process//proteolysis GO:0016758//GO:0018024//GO:0004252//GO:0016301 transferase activity, transferring hexosyl groups//histone-lysine N-methyltransferase activity//serine-type endopeptidase activity//kinase activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.3928 BF_2 7.00 0.34 1140 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39281 BF_2 7.00 3.88 359 83658844 ABC40572.1 137 3.0e-06 putative antimicrobial knottin protein Btk-4 [Bemisia tabaci] -- -- -- -- -- -- -- -- -- P83653 205 1.6e-15 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.39282 BF_2 61.87 0.85 3346 270001607 EEZ98054.1 1648 1.7e-180 hypothetical protein TcasGA2_TC000459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K1C7 300 1.5e-25 Monocarboxylate transporter 14 OS=Mus musculus GN=Slc16a14 PE=2 SV=1 PF07690//PF02308 Major Facilitator Superfamily//MgtC family GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.39284 BF_2 2328.08 11.39 8837 270001798 EEZ98245.1 3602 0.0e+00 hypothetical protein TcasGA2_TC000684 [Tribolium castaneum] 645014380 XM_008205235.1 469 0 PREDICTED: Nasonia vitripennis uncharacterized LOC100118209 (LOC100118209), transcript variant X4, mRNA -- -- -- -- Q14554 162 3.9e-09 Protein disulfide-isomerase A5 OS=Homo sapiens GN=PDIA5 PE=1 SV=1 PF02020//PF01791//PF00085//PF02382//PF07689//PF00578 eIF4-gamma/eIF5/eIF2-epsilon//DeoC/LacD family aldolase//Thioredoxin//RTX N-terminal domain//KaiB domain//AhpC/TSA family GO:0048511//GO:0009405//GO:0045454//GO:0055114 rhythmic process//pathogenesis//cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0005515//GO:0016209//GO:0005509//GO:0016829 oxidoreductase activity//protein binding//antioxidant activity//calcium ion binding//lyase activity GO:0005576 extracellular region KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.39285 BF_2 1077.49 17.87 2810 642933110 XP_008197262.1 1355 1.4e-146 PREDICTED: prominin-like protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 398 5.3e-37 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF04513//PF01442//PF07926//PF05478//PF07464//PF13903 Baculovirus polyhedron envelope protein, PEP, C terminus//Apolipoprotein A1/A4/E domain//TPR/MLP1/MLP2-like protein//Prominin//Apolipophorin-III precursor (apoLp-III)//PMP-22/EMP/MP20/Claudin tight junction GO:0006606//GO:0042157//GO:0006869 protein import into nucleus//lipoprotein metabolic process//lipid transport GO:0008289//GO:0005198 lipid binding//structural molecule activity GO:0005576//GO:0019028//GO:0016021//GO:0019031 extracellular region//viral capsid//integral component of membrane//viral envelope KOG4331 Polytopic membrane protein Prominin Cluster-8309.39286 BF_2 136.90 3.54 1907 91093829 XP_969227.1 1839 7.1e-203 PREDICTED: transmembrane protein 161B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2L6 1009 5.1e-108 Transmembrane protein 161B OS=Mus musculus GN=Tmem161b PE=2 SV=1 PF04632//PF00336 Fusaric acid resistance protein family//DNA polymerase (viral) C-terminal domain GO:0006810//GO:0051252 transport//regulation of RNA metabolic process GO:0004523 RNA-DNA hybrid ribonuclease activity GO:0005886 plasma membrane KOG3978 Predicted membrane protein Cluster-8309.39288 BF_2 4672.63 28.80 7074 270005756 EFA02204.1 1196 9.5e-128 hypothetical protein TcasGA2_TC007862 [Tribolium castaneum] 642919215 XM_963943.3 252 2.64422e-126 PREDICTED: Tribolium castaneum uncharacterized LOC657485 (LOC657485), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39289 BF_2 1762.41 166.11 731 270009349 EFA05797.1 614 3.0e-61 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 320 1.5e-28 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.39290 BF_2 5472.39 43.64 5533 270009349 EFA05797.1 798 1.1e-81 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 463 3.0e-44 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.39291 BF_2 329.32 1.31 10770 642910658 XP_008200046.1 10281 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.39292 BF_2 245.75 2.16 5047 642910281 XP_008198657.1 720 1.1e-72 PREDICTED: prolyl 3-hydroxylase 1-like [Tribolium castaneum] -- -- -- -- -- K08134 LEPRE leucine proline-enriched proteoglycan (leprecan) http://www.genome.jp/dbget-bin/www_bget?ko:K08134 Q3V1T4 315 4.0e-27 Prolyl 3-hydroxylase 1 OS=Mus musculus GN=Lepre1 PE=2 SV=2 PF00515 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.39293 BF_2 376.67 3.96 4270 -- -- -- -- -- 642918185 XM_008193179.1 85 1.08789e-33 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39294 BF_2 2173.46 9.21 10154 642932320 XP_008197063.1 11376 0.0e+00 PREDICTED: unconventional myosin-XV [Tribolium castaneum] 642932319 XM_008198841.1 537 0 PREDICTED: Tribolium castaneum myosin 15 (LOC658144), mRNA K10361 MYO15 myosin XV http://www.genome.jp/dbget-bin/www_bget?ko:K10361 Q9UKN7 2051 4.0e-228 Unconventional myosin-XV OS=Homo sapiens GN=MYO15A PE=1 SV=2 PF00063//PF00784//PF00612 Myosin head (motor domain)//MyTH4 domain//IQ calmodulin-binding motif -- -- GO:0005524//GO:0003774//GO:0005515 ATP binding//motor activity//protein binding GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.39296 BF_2 1021.05 90.52 759 91087837 XP_967757.1 757 8.2e-78 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 530 7.1e-53 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01370//PF01715//PF00227 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//IPP transferase//Proteasome subunit GO:0008033//GO:0051603//GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 tRNA processing//proteolysis involved in cellular protein catabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0004298//GO:0016616//GO:0003854//GO:0003824//GO:0050662 threonine-type endopeptidase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding GO:0005839 proteasome core complex KOG1221 Acyl-CoA reductase Cluster-8309.39298 BF_2 49.10 1.25 1930 270002493 EEZ98940.1 798 3.7e-82 hypothetical protein TcasGA2_TC004563 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IX12 603 6.2e-61 Cell division cycle and apoptosis regulator protein 1 OS=Homo sapiens GN=CCAR1 PE=1 SV=2 PF06495//PF01247//PF02724//PF03153 Fruit fly transformer protein//Ribosomal protein L35Ae//CDC45-like protein//Transcription factor IIA, alpha/beta subunit GO:0006270//GO:0006412//GO:0006397//GO:0042254//GO:0046660//GO:0006367 DNA replication initiation//translation//mRNA processing//ribosome biogenesis//female sex differentiation//transcription initiation from RNA polymerase II promoter GO:0003735 structural constituent of ribosome GO:0005634//GO:0005622//GO:0005672//GO:0005840 nucleus//intracellular//transcription factor TFIIA complex//ribosome -- -- Cluster-8309.39299 BF_2 54.87 0.48 5102 642912125 XP_008200817.1 847 2.0e-87 PREDICTED: cell division cycle and apoptosis regulator protein 1-like [Tribolium castaneum] 572309672 XM_006620560.1 86 3.61912e-34 PREDICTED: Apis dorsata cell division cycle and apoptosis regulator protein 1-like (LOC102677857), transcript variant X2, mRNA -- -- -- -- Q8CH18 421 2.1e-39 Cell division cycle and apoptosis regulator protein 1 OS=Mus musculus GN=Ccar1 PE=1 SV=1 PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG4246 Predicted DNA-binding protein, contains SAP domain Cluster-8309.39300 BF_2 2195.56 45.95 2286 167234457 NP_001107844.1 1522 4.8e-166 eukaryotic translation initiation factor 5 [Tribolium castaneum]>gi|642919625|ref|XP_008191995.1| PREDICTED: eukaryotic translation initiation factor 5 isoform X1 [Tribolium castaneum]>gi|270005452|gb|EFA01900.1| hypothetical protein TcasGA2_TC007510 [Tribolium castaneum] 167234456 NM_001114372.1 159 4.22643e-75 Tribolium castaneum eukaryotic translation initiation factor 5 (Eif5), mRNA K03262 EIF5 translation initiation factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03262 Q9VXK6 1299 1.4e-141 Eukaryotic translation initiation factor 5 OS=Drosophila melanogaster GN=eIF5 PE=1 SV=1 PF02020//PF14489//PF01873 eIF4-gamma/eIF5/eIF2-epsilon//QueF-like protein//Domain found in IF2B/IF5 GO:0044238//GO:0006413//GO:0006446//GO:0008616//GO:0044260 primary metabolic process//translational initiation//regulation of translational initiation//queuosine biosynthetic process//cellular macromolecule metabolic process GO:0033739//GO:0005515//GO:0003743 preQ1 synthase activity//protein binding//translation initiation factor activity GO:0005840 ribosome KOG2767 Translation initiation factor 5 (eIF-5) Cluster-8309.39301 BF_2 2746.84 74.57 1828 478259294 ENN79196.1 2111 1.9e-234 hypothetical protein YQE_04380, partial [Dendroctonus ponderosae]>gi|546681735|gb|ERL91767.1| hypothetical protein D910_09093 [Dendroctonus ponderosae] 826415366 XM_012666952.1 54 7.87692e-17 PREDICTED: Monomorium pharaonis ABC transporter G family member 20 (LOC105828568), transcript variant X3, mRNA -- -- -- -- Q8T674 387 6.5e-36 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.39302 BF_2 272.53 1.40 8402 646715813 KDR19281.1 1054 3.3e-111 Schwannomin-interacting protein 1 [Zootermopsis nevadensis] 642924593 XM_008196134.1 241 4.09489e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.6e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.39303 BF_2 134.22 3.03 2142 759001854 AJP08639.1 1866 5.9e-206 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 475 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1636 1.1e-180 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF00069//PF06293//PF03242 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Late embryogenesis abundant protein GO:0006468//GO:0006950 protein phosphorylation//response to stress GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane -- -- Cluster-8309.39306 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39307 BF_2 613.63 8.41 3338 642935023 XP_008199910.1 1215 2.8e-130 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 770 4.6e-80 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF08925//PF11547//PF00076//PF16367 Domain of Unknown Function (DUF1907)//E3 ubiquitin ligase EDD//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676//GO:0043130 nucleic acid binding//ubiquitin binding GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.39310 BF_2 8.00 2.84 404 91095123 XP_970890.1 201 1.3e-13 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 135 2.4e-07 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF01073//PF02737//PF01370//PF02558//PF02882//PF12242 short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0018874//GO:0006633//GO:0008210//GO:0006631//GO:0006552//GO:0015940//GO:0006574//GO:0006550//GO:0046487//GO:0009396//GO:0006568//GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0006554 metabolic process//benzoate metabolic process//fatty acid biosynthetic process//estrogen metabolic process//fatty acid metabolic process//leucine catabolic process//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//tryptophan metabolic process//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//lysine catabolic process GO:0003824//GO:0016491//GO:0008677//GO:0003854//GO:0050662//GO:0016616//GO:0004488//GO:0003857 catalytic activity//oxidoreductase activity//2-dehydropantoate 2-reductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//methylenetetrahydrofolate dehydrogenase (NADP+) activity//3-hydroxyacyl-CoA dehydrogenase activity -- -- -- -- Cluster-8309.39311 BF_2 20129.60 117.54 7451 270004724 EFA01172.1 1927 1.7e-212 hypothetical protein TcasGA2_TC010495 [Tribolium castaneum] 642917347 XM_965116.3 424 0 PREDICTED: Tribolium castaneum MAP kinase-interacting serine/threonine-protein kinase 1 (LOC658754), transcript variant X2, mRNA K04372 MKNK, MNK MAP kinase interacting serine/threonine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04372 Q9HBH9 1110 3.9e-119 MAP kinase-interacting serine/threonine-protein kinase 2 OS=Homo sapiens GN=MKNK2 PE=1 SV=3 PF12937//PF13516//PF07714//PF06293//PF00646//PF00069 F-box-like//Leucine Rich repeat//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//F-box domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0016773//GO:0005524 protein binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0607 MAP kinase-interacting kinase and related serine/threonine protein kinases Cluster-8309.39312 BF_2 39.87 0.39 4556 646717218 KDR20164.1 788 1.3e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.45012e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.8e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF16367//PF00076//PF00313 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.39313 BF_2 589.19 26.74 1209 642912175 XP_008200838.1 822 3.8e-85 PREDICTED: heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog isoform X2 [Tribolium castaneum] 780671672 XM_011697100.1 128 3.76766e-58 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 7.5e-73 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.39314 BF_2 2007.11 51.83 1907 91088497 XP_971106.1 1588 9.0e-174 PREDICTED: hydroxysteroid dehydrogenase-like protein 2 [Tribolium castaneum]>gi|270012748|gb|EFA09196.1| hypothetical protein TcasGA2_TC005801 [Tribolium castaneum] 195430189 XM_002063103.1 51 3.82625e-15 Drosophila willistoni GK21765 (Dwil\GK21765), mRNA -- -- -- -- Q6PAY8 1225 4.6e-133 Hydroxysteroid dehydrogenase-like protein 2 OS=Xenopus laevis GN=hsdl2 PE=2 SV=1 PF00106//PF12242 short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0000166//GO:0032934//GO:0016491 nucleotide binding//sterol binding//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.39316 BF_2 2288.16 45.24 2403 642923928 XP_008193931.1 1561 1.5e-170 PREDICTED: probable serine incorporator isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHV9 971 1.6e-103 Serine incorporator 1 OS=Bos taurus GN=SERINC1 PE=2 SV=1 PF03348 Serine incorporator (Serinc) -- -- -- -- GO:0016020 membrane KOG2592 Tumor differentially expressed (TDE) protein Cluster-8309.39317 BF_2 768.73 20.32 1870 642922960 XP_008200469.1 255 3.3e-19 PREDICTED: uncharacterized protein LOC100142444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39318 BF_2 254.98 18.40 867 91095123 XP_970890.1 503 2.7e-48 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 360 4.2e-33 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF03857//PF00106 Colicin immunity protein//short chain dehydrogenase GO:0008152//GO:0006955//GO:0030153 metabolic process//immune response//bacteriocin immunity GO:0015643//GO:0016491 toxic substance binding//oxidoreductase activity GO:0019814 immunoglobulin complex -- -- Cluster-8309.39319 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06156 Protein of unknown function (DUF972) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.39320 BF_2 320.11 3.48 4132 642925010 XP_008194133.1 4674 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit beta isoform X3 [Tribolium castaneum] 759033712 XM_011331767.1 146 1.29563e-67 PREDICTED: Cerapachys biroi probable phosphorylase b kinase regulatory subunit beta (LOC105275114), transcript variant X1, mRNA K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9VLS1 3842 0.0e+00 Probable phosphorylase b kinase regulatory subunit beta OS=Drosophila melanogaster GN=CG8475 PE=2 SV=2 PF03293//PF03485//PF15014//PF02055//PF05236//PF03540 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Arginyl tRNA synthetase N terminal domain//Ceroid-lipofuscinosis neuronal protein 5//O-Glycosyl hydrolase family 30//Transcription initiation factor TFIID component TAF4 family//Transcription initiation factor TFIID 23-30kDa subunit GO:0006420//GO:0005975//GO:0006687//GO:0006525//GO:0019083//GO:0006665//GO:0022008//GO:0006206//GO:0006807//GO:0006352//GO:0006351//GO:0006144//GO:0006560 arginyl-tRNA aminoacylation//carbohydrate metabolic process//glycosphingolipid metabolic process//arginine metabolic process//viral transcription//sphingolipid metabolic process//neurogenesis//pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//DNA-templated transcription, initiation//transcription, DNA-templated//purine nucleobase metabolic process//proline metabolic process GO:0000166//GO:0004348//GO:0003899//GO:0005524//GO:0003677//GO:0004814 nucleotide binding//glucosylceramidase activity//DNA-directed RNA polymerase activity//ATP binding//DNA binding//arginine-tRNA ligase activity GO:0005764//GO:0005669//GO:0005737//GO:0005730//GO:0005634 lysosome//transcription factor TFIID complex//cytoplasm//nucleolus//nucleus KOG3635 Phosphorylase kinase Cluster-8309.39321 BF_2 67.85 0.51 5890 642914570 XP_008190269.1 1437 9.0e-156 PREDICTED: dnaJ homolog subfamily C member 10-like [Tribolium castaneum] -- -- -- -- -- K09530 DNAJC10 DnaJ homolog subfamily C member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09530 Q5R5L3 724 1.8e-74 DnaJ homolog subfamily C member 10 OS=Pongo abelii GN=DNAJC10 PE=2 SV=1 PF00578//PF00085//PF08534//PF01216 AhpC/TSA family//Thioredoxin//Redoxin//Calsequestrin GO:0055114//GO:0045454 oxidation-reduction process//cell redox homeostasis GO:0016491//GO:0005509//GO:0016209 oxidoreductase activity//calcium ion binding//antioxidant activity -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.39323 BF_2 17.50 1.84 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39324 BF_2 1509.84 35.27 2078 478256311 ENN76501.1 492 1.2e-46 hypothetical protein YQE_06953, partial [Dendroctonus ponderosae]>gi|546673478|gb|ERL85073.1| hypothetical protein D910_02496 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39325 BF_2 1699.00 27.10 2910 270002395 EEZ98842.1 2020 1.1e-223 hypothetical protein TcasGA2_TC004451 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q8BX70 1076 1.3e-115 Vacuolar protein sorting-associated protein 13C OS=Mus musculus GN=Vps13c PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.39326 BF_2 1645.84 7.48 9490 642912633 XP_008200941.1 5658 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q96RL7 2271 1.2e-253 Vacuolar protein sorting-associated protein 13A OS=Homo sapiens GN=VPS13A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.39328 BF_2 7549.99 49.88 6619 189237751 XP_001812575.1 3801 0.0e+00 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 9.8e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF04769//PF08070 PX domain//Mating-type protein MAT alpha 1 HMG-box//DTHCT (NUC029) region GO:0007531//GO:0006265//GO:0045895 mating type determination//DNA topological change//positive regulation of mating-type specific transcription, DNA-templated GO:0035091//GO:0003677//GO:0005524//GO:0008301//GO:0003918 phosphatidylinositol binding//DNA binding//ATP binding//DNA binding, bending//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005634 nucleus KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.39329 BF_2 6813.90 104.99 3002 91084907 XP_969916.1 3790 0.0e+00 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 389 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2970 0.0e+00 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911//PF00551 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain//Formyl transferase GO:0009058//GO:0055114//GO:0032259//GO:0008152 biosynthetic process//oxidation-reduction process//methylation//metabolic process GO:0016742//GO:0008168//GO:0016620//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//methyltransferase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.39332 BF_2 666.38 15.68 2065 642915315 XP_008190568.1 2642 5.9e-296 PREDICTED: dosage compensation regulator isoform X2 [Tribolium castaneum] 195155373 XM_002018544.1 260 2.72586e-131 Drosophila persimilis GL17788 (Dper\GL17788), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1906 5.3e-212 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF04408 Helicase associated domain (HA2) -- -- GO:0004386 helicase activity -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.39334 BF_2 1017.15 37.43 1424 91085783 XP_974443.1 1714 1.6e-188 PREDICTED: fumarylacetoacetase [Tribolium castaneum]>gi|270009995|gb|EFA06443.1| hypothetical protein TcasGA2_TC009325 [Tribolium castaneum] -- -- -- -- -- K01555 FAH, fahA fumarylacetoacetase http://www.genome.jp/dbget-bin/www_bget?ko:K01555 A5PKH3 1362 4.4e-149 Fumarylacetoacetase OS=Bos taurus GN=FAH PE=2 SV=1 PF09298//PF01557 Fumarylacetoacetase N-terminal//Fumarylacetoacetate (FAA) hydrolase family GO:0042207//GO:0006570//GO:0008152//GO:0009072 styrene catabolic process//tyrosine metabolic process//metabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0003824 fumarylacetoacetase activity//catalytic activity -- -- KOG2843 Fumarylacetoacetase Cluster-8309.39335 BF_2 1179.00 49.68 1280 332375733 AEE63007.1 1236 4.0e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P49638 206 4.4e-15 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39336 BF_2 958.40 4.60 9009 646710408 KDR15927.1 1190 6.0e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.75794e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.39337 BF_2 114.00 31.11 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39338 BF_2 737.25 20.70 1777 91079236 XP_970901.1 1361 1.8e-147 PREDICTED: tubulin-specific chaperone E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KS0 795 3.1e-83 Tubulin-specific chaperone E OS=Bos taurus GN=TBCE PE=2 SV=1 PF13855//PF00564 Leucine rich repeat//PB1 domain -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.39339 BF_2 83.39 0.33 10969 642935792 XP_008198176.1 3966 0.0e+00 PREDICTED: nitric oxide synthase, salivary gland isoform X2 [Tribolium castaneum] 148367285 AB304919.1 233 1.49848e-115 Luciola lateralis LlNOS mRNA for nitric oxide synthase, complete cds K13240 NOS1 nitric-oxide synthase, brain http://www.genome.jp/dbget-bin/www_bget?ko:K13240 B1B557 3028 0.0e+00 Nitric oxide synthase-like protein OS=Bombyx mori GN=NSL PE=2 SV=1 PF04103//PF01040//PF00175//PF00802//PF02898//PF00667//PF10505//PF01384//PF00258//PF09570//PF00335 CD20-like family//UbiA prenyltransferase family//Oxidoreductase NAD-binding domain//Pneumovirus attachment glycoprotein G//Nitric oxide synthase, oxygenase domain//FAD binding domain//NMDA receptor-regulated gene protein 2 C-terminus//Phosphate transporter family//Flavodoxin//SinI restriction endonuclease//Tetraspanin family GO:0055114//GO:0009307//GO:0006809//GO:0006817//GO:0006308 oxidation-reduction process//DNA restriction-modification system//nitric oxide biosynthetic process//phosphate ion transport//DNA catabolic process GO:0005315//GO:0010181//GO:0004517//GO:0004659//GO:0016491//GO:0003677//GO:0009036 inorganic phosphate transmembrane transporter activity//FMN binding//nitric-oxide synthase activity//prenyltransferase activity//oxidoreductase activity//DNA binding//Type II site-specific deoxyribonuclease activity GO:0055036//GO:0016021//GO:0009359//GO:0016020//GO:0008023 virion membrane//integral component of membrane//Type II site-specific deoxyribonuclease complex//membrane//transcription elongation factor complex KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.39340 BF_2 2330.78 9.00 11121 642934315 XP_008198597.1 2307 2.2e-256 PREDICTED: integrin alpha-PS2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 1766 4.9e-195 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF15686//PF05375 Lysine-rich CEACAM1 co-isolated protein family//Pacifastin inhibitor (LCMII) GO:0043066//GO:0043123//GO:0045766 negative regulation of apoptotic process//positive regulation of I-kappaB kinase/NF-kappaB signaling//positive regulation of angiogenesis GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.39341 BF_2 17.69 0.31 2650 91086797 XP_973406.1 1564 7.6e-171 PREDICTED: CTD small phosphatase-like protein 2 [Tribolium castaneum]>gi|270009707|gb|EFA06155.1| hypothetical protein TcasGA2_TC009000 [Tribolium castaneum] -- -- -- -- -- K17616 CTDSPL2 CTD small phosphatase-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17616 Q66KM5 813 3.8e-85 CTD small phosphatase-like protein 2 OS=Xenopus tropicalis GN=ctdspl2 PE=2 SV=1 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.39343 BF_2 6.00 0.34 1030 91089425 XP_974427.1 517 7.5e-50 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011414|gb|EFA07862.1| hypothetical protein TcasGA2_TC005436 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 377 5.3e-35 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39344 BF_2 15.01 0.56 1404 642928554 XP_008195373.1 146 1.1e-06 PREDICTED: uncharacterized protein LOC661472 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39345 BF_2 340.85 3.28 4629 642936873 XP_969385.2 1554 1.9e-169 PREDICTED: cdc42-interacting protein 4 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97531 566 2.9e-56 Cdc42-interacting protein 4 OS=Rattus norvegicus GN=Trip10 PE=1 SV=3 PF02185//PF00018//PF14604 Hr1 repeat//SH3 domain//Variant SH3 domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.39346 BF_2 266.01 1.50 7711 642936871 XP_008193040.1 1572 2.6e-171 PREDICTED: formin-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RU3 725 1.8e-74 Formin-binding protein 1 OS=Homo sapiens GN=FNBP1 PE=1 SV=2 PF14604//PF00018//PF02185//PF09177//PF00816 Variant SH3 domain//SH3 domain//Hr1 repeat//Syntaxin 6, N-terminal//H-NS histone family GO:0048193//GO:0006355//GO:0007165 Golgi vesicle transport//regulation of transcription, DNA-templated//signal transduction GO:0005515//GO:0003677 protein binding//DNA binding GO:0016020//GO:0005622 membrane//intracellular KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.39348 BF_2 308.32 9.91 1589 546672637 ERL84433.1 1024 1.9e-108 hypothetical protein D910_01865, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5YCC5 398 3.0e-37 Transmembrane channel-like protein 7 OS=Gallus gallus GN=Tmc7 PE=2 SV=1 PF06305//PF07810 Protein of unknown function (DUF1049)//TMC domain -- -- -- -- GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.39349 BF_2 1476.22 53.99 1431 189235746 XP_967247.2 919 2.5e-96 PREDICTED: tRNA-specific adenosine deaminase 1 [Tribolium castaneum]>gi|270004485|gb|EFA00933.1| hypothetical protein TcasGA2_TC003839 [Tribolium castaneum] -- -- -- -- -- K15440 TAD1, ADAT1 tRNA-specific adenosine deaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15440 Q9V3R6 522 1.1e-51 tRNA-specific adenosine deaminase 1 OS=Drosophila melanogaster GN=adat PE=1 SV=1 PF02137 Adenosine-deaminase (editase) domain GO:0006396//GO:0006807//GO:0006144 RNA processing//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.39350 BF_2 47.00 28.05 353 332374310 AEE62296.1 289 7.0e-24 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O80944 170 1.8e-11 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.39351 BF_2 600.60 8.72 3167 642917800 XP_008191291.1 861 3.0e-89 PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|642917802|ref|XP_008191292.1| PREDICTED: prostaglandin F synthase-like [Tribolium castaneum]>gi|270004486|gb|EFA00934.1| hypothetical protein TcasGA2_TC003840 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 424 5.8e-40 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF04539//PF01353 Sigma-70 region 3//Green fluorescent protein GO:0008218//GO:0006352//GO:0055114//GO:0006355 bioluminescence//DNA-templated transcription, initiation//oxidation-reduction process//regulation of transcription, DNA-templated GO:0016491//GO:0003677//GO:0003700//GO:0016987 oxidoreductase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667 transcription factor complex KOG1577 Aldo/keto reductase family proteins Cluster-8309.39352 BF_2 2778.76 45.55 2839 642923797 XP_008193887.1 1826 3.4e-201 PREDICTED: uncharacterized protein LOC663689 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04999//PF13014//PF00013 Cell division protein FtsL//KH domain//KH domain GO:0051301//GO:0007049 cell division//cell cycle GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.39354 BF_2 191.86 4.13 2231 642917609 XP_008191278.1 1425 8.4e-155 PREDICTED: U3 small nucleolar RNA-associated protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VCY6 452 2.3e-43 U3 small nucleolar RNA-associated protein 6 homolog OS=Mus musculus GN=Utp6 PE=2 SV=1 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG2396 HAT (Half-A-TPR) repeat-containing protein Cluster-8309.39356 BF_2 567.25 4.01 6205 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.26946e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.2e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF00787//PF00620//PF00018//PF14604//PF01929 PX domain//RhoGAP domain//SH3 domain//Variant SH3 domain//Ribosomal protein L14 GO:0042254//GO:0007154//GO:0006412//GO:0007165 ribosome biogenesis//cell communication//translation//signal transduction GO:0003735//GO:0035091//GO:0005515 structural constituent of ribosome//phosphatidylinositol binding//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.39357 BF_2 656.04 17.95 1816 189235069 XP_974729.2 1603 1.6e-175 PREDICTED: nocturnin isoform X4 [Tribolium castaneum]>gi|642915409|ref|XP_008190602.1| PREDICTED: nocturnin isoform X4 [Tribolium castaneum] -- -- -- -- -- K18764 CCRN4L nocturnin http://www.genome.jp/dbget-bin/www_bget?ko:K18764 Q9UK39 748 8.9e-78 Nocturnin OS=Homo sapiens GN=CCRN4L PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.39358 BF_2 1014.56 8.80 5112 642924384 XP_008194273.1 2554 2.3e-285 PREDICTED: WD repeat-containing protein 59 [Tribolium castaneum]>gi|270007891|gb|EFA04339.1| hypothetical protein TcasGA2_TC014633 [Tribolium castaneum] 195162816 XM_002022214.1 101 1.66343e-42 Drosophila persimilis GL24697 (Dper\GL24697), mRNA -- -- -- -- Q5ZLG9 1355 1.0e-147 WD repeat-containing protein 59 OS=Gallus gallus GN=WDR59 PE=2 SV=1 PF02459//PF05773//PF00324//PF00400//PF13520 Adenoviral DNA terminal protein//RWD domain//Amino acid permease//WD domain, G-beta repeat//Amino acid permease GO:0006865//GO:0055085//GO:0006810//GO:0003333//GO:0006260 amino acid transport//transmembrane transport//transport//amino acid transmembrane transport//DNA replication GO:0003677//GO:0015171//GO:0005515 DNA binding//amino acid transmembrane transporter activity//protein binding GO:0016020 membrane -- -- Cluster-8309.39359 BF_2 14.55 0.38 1882 91083729 XP_970665.1 535 1.1e-51 PREDICTED: Y+L amino acid transporter 2 [Tribolium castaneum]>gi|270006804|gb|EFA03252.1| hypothetical protein TcasGA2_TC013186 [Tribolium castaneum] -- -- -- -- -- K13780 SLC7A5, LAT1 solute carrier family 7 (L-type amino acid transporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13780 Q63016 275 6.5e-23 Large neutral amino acids transporter small subunit 1 OS=Rattus norvegicus GN=Slc7a5 PE=1 SV=2 -- -- GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016021 integral component of membrane KOG1287 Amino acid transporters Cluster-8309.39360 BF_2 80.00 4.26 1073 642925601 XP_001812139.2 143 1.8e-06 PREDICTED: uncharacterized protein LOC660114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- -- -- Cluster-8309.39362 BF_2 541.92 2.46 9496 270005159 EFA01607.1 9105 0.0e+00 hypothetical protein TcasGA2_TC007173 [Tribolium castaneum] 642920908 XM_008194389.1 1881 0 PREDICTED: Tribolium castaneum spectrin beta chain (LOC661354), transcript variant X7, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q00963 7565 0.0e+00 Spectrin beta chain OS=Drosophila melanogaster GN=beta-Spec PE=1 SV=2 PF00307//PF00435 Calponin homology (CH) domain//Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.39364 BF_2 304.48 2.39 5606 642934778 XP_008197804.1 5467 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein flightless-1 [Tribolium castaneum] 262305210 GQ887625.1 163 6.24783e-77 Metajapyx subterraneus voucher JapDIPLUR gelsolin mRNA, partial cds -- -- -- -- Q24020 4259 0.0e+00 Protein flightless-1 OS=Drosophila melanogaster GN=fliI PE=2 SV=1 PF13855//PF15721//PF08661//PF00560 Leucine rich repeat//Annexin-2 receptor//Replication factor A protein 3//Leucine Rich Repeat GO:0006310//GO:0006260//GO:0007165//GO:0006281 DNA recombination//DNA replication//signal transduction//DNA repair GO:0003677//GO:0004872//GO:0005515 DNA binding//receptor activity//protein binding GO:0005634 nucleus KOG0444 Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats) Cluster-8309.39366 BF_2 11.03 0.36 1574 546678047 ERL88771.1 746 3.2e-76 hypothetical protein D910_06153 [Dendroctonus ponderosae] -- -- -- -- -- K01277 DPP3 dipeptidyl-peptidase III http://www.genome.jp/dbget-bin/www_bget?ko:K01277 Q9VHR8 495 1.7e-48 Dipeptidyl peptidase 3 OS=Drosophila melanogaster GN=DppIII PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3675 Dipeptidyl peptidase III Cluster-8309.39367 BF_2 623.15 9.09 3155 478259909 ENN79711.1 3590 0.0e+00 hypothetical protein YQE_03768, partial [Dendroctonus ponderosae] 462367530 APGK01026876.1 80 4.8232e-31 Dendroctonus ponderosae Seq01026886, whole genome shotgun sequence K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q01484 2721 2.6e-306 Ankyrin-2 OS=Homo sapiens GN=ANK2 PE=1 SV=4 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.39368 BF_2 40.74 1.27 1634 642930878 XP_008196122.1 205 1.8e-13 PREDICTED: uncharacterized protein LOC658955 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3937 BF_2 7.00 6.95 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39374 BF_2 54.33 0.34 7047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39375 BF_2 643.21 2.28 12104 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 2.5e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00448//PF01225//PF13304//PF06414//PF00005//PF03193 SRP54-type protein, GTPase domain//Mur ligase family, catalytic domain//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006614//GO:0009058 SRP-dependent cotranslational protein targeting to membrane//biosynthetic process GO:0005524//GO:0005525//GO:0016301//GO:0016887//GO:0003924 ATP binding//GTP binding//kinase activity//ATPase activity//GTPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.39382 BF_2 1238.18 17.02 3330 642931643 XP_008196669.1 765 4.3e-78 PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum]>gi|642931645|ref|XP_972490.2| PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum] -- -- -- -- -- K04701 CISH cytokine inducible SH2-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04701 O14508 228 3.2e-17 Suppressor of cytokine signaling 2 OS=Homo sapiens GN=SOCS2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.39383 BF_2 887.33 10.14 3947 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39384 BF_2 353.35 4.12 3872 642931522 XP_008196620.1 1351 5.5e-146 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 968 5.9e-103 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00288//PF00640 GHMP kinases N terminal domain//Phosphotyrosine interaction domain (PTB/PID) GO:0006012//GO:0046835 galactose metabolic process//carbohydrate phosphorylation GO:0004335//GO:0005515//GO:0005524 galactokinase activity//protein binding//ATP binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.39386 BF_2 921.26 9.27 4446 642931522 XP_008196620.1 1438 5.2e-156 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 1029 5.7e-110 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00640//PF00288 Phosphotyrosine interaction domain (PTB/PID)//GHMP kinases N terminal domain GO:0046835//GO:0006012 carbohydrate phosphorylation//galactose metabolic process GO:0005515//GO:0004335//GO:0005524 protein binding//galactokinase activity//ATP binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.39390 BF_2 66.05 0.79 3803 91091418 XP_971893.1 623 1.4e-61 PREDICTED: protein-associating with the carboxyl-terminal domain of ezrin [Tribolium castaneum]>gi|270000964|gb|EEZ97411.1| hypothetical protein TcasGA2_TC011240 [Tribolium castaneum] -- -- -- -- -- K17542 SCYL3 SCY1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17542 Q8IZE3 212 2.7e-15 Protein-associating with the carboxyl-terminal domain of ezrin OS=Homo sapiens GN=SCYL3 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39391 BF_2 317.31 3.46 4127 91091418 XP_971893.1 1787 1.6e-196 PREDICTED: protein-associating with the carboxyl-terminal domain of ezrin [Tribolium castaneum]>gi|270000964|gb|EEZ97411.1| hypothetical protein TcasGA2_TC011240 [Tribolium castaneum] -- -- -- -- -- K17542 SCYL3 SCY1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17542 Q9DBQ7 624 4.8e-63 Protein-associating with the carboxyl-terminal domain of ezrin OS=Mus musculus GN=Scyl3 PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1243 Protein kinase Cluster-8309.39392 BF_2 266.69 1.45 7957 642936743 XP_008198562.1 4787 0.0e+00 PREDICTED: neurexin-4 isoform X1 [Tribolium castaneum] 662206951 XM_008478733.1 135 3.2627e-61 PREDICTED: Diaphorina citri neurexin-4-like (LOC103513882), mRNA -- -- -- -- Q94887 4092 0.0e+00 Neurexin-4 OS=Drosophila melanogaster GN=Nrx-IV PE=1 SV=2 PF01106//PF00008//PF01648//PF03079 NifU-like domain//EGF-like domain//4'-phosphopantetheinyl transferase superfamily//ARD/ARD' family GO:0016226//GO:0015940//GO:0055114 iron-sulfur cluster assembly//pantothenate biosynthetic process//oxidation-reduction process GO:0010309//GO:0005515//GO:0008897//GO:0051536//GO:0005506//GO:0000287 acireductone dioxygenase [iron(II)-requiring] activity//protein binding//holo-[acyl-carrier-protein] synthase activity//iron-sulfur cluster binding//iron ion binding//magnesium ion binding -- -- -- -- Cluster-8309.39394 BF_2 174.93 28.48 544 270002182 EEZ98629.1 151 1.1e-07 hypothetical protein TcasGA2_TC001152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01623 Carlavirus putative nucleic acid binding protein GO:0006355 regulation of transcription, DNA-templated GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.39397 BF_2 184.49 3.97 2230 642919704 XP_008192030.1 2793 0.0e+00 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] 807042760 XM_012306425.1 116 3.30066e-51 PREDICTED: Ceratitis capitata serine/threonine-protein kinase par-1 (LOC101453227), transcript variant X3, mRNA K16311 SIK2 serine/threonine-protein kinase SIK2 http://www.genome.jp/dbget-bin/www_bget?ko:K16311 Q9H0K1 1262 2.7e-137 Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.39399 BF_2 339.26 17.42 1102 642926175 XP_008194816.1 1560 9.1e-171 PREDICTED: vinculin isoform X6 [Tribolium castaneum] -- -- -- -- -- K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 1027 2.4e-110 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF01442//PF06009 Vinculin family//Apolipoprotein A1/A4/E domain//Laminin Domain II GO:0006869//GO:0042157//GO:0007155 lipid transport//lipoprotein metabolic process//cell adhesion GO:0051015//GO:0008289 actin filament binding//lipid binding GO:0005576 extracellular region KOG3681 Alpha-catenin Cluster-8309.394 BF_2 6.00 0.42 881 16753227 NP_000961.2 1158 3.0e-124 60S ribosomal protein L6 [Homo sapiens]>gi|67189747|ref|NP_001019833.1| 60S ribosomal protein L6 [Homo sapiens]>gi|350538033|ref|NP_001233502.1| 60S ribosomal protein L6 [Pan troglodytes]>gi|397482836|ref|XP_003812622.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|397525062|ref|XP_003832497.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|426374199|ref|XP_004053967.1| PREDICTED: 60S ribosomal protein L6 isoform 1 [Gorilla gorilla gorilla]>gi|426374201|ref|XP_004053968.1| PREDICTED: 60S ribosomal protein L6 isoform 2 [Gorilla gorilla gorilla]>gi|426374203|ref|XP_004053969.1| PREDICTED: 60S ribosomal protein L6 isoform 3 [Gorilla gorilla gorilla]>gi|426374205|ref|XP_004053970.1| PREDICTED: 60S ribosomal protein L6 isoform 4 [Gorilla gorilla gorilla]>gi|578824095|ref|XP_006719609.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Homo sapiens]>gi|578824097|ref|XP_006719610.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Homo sapiens]>gi|578824099|ref|XP_006719611.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Homo sapiens]>gi|578824101|ref|XP_006719612.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Homo sapiens]>gi|675713874|ref|XP_008962237.1| PREDICTED: LOW QUALITY PROTEIN: 60S ribosomal protein L6-like [Pan paniscus]>gi|675754355|ref|XP_008971319.1| PREDICTED: LOW QUALITY PROTEIN: 60S ribosomal protein L6-like [Pan paniscus]>gi|675800041|ref|XP_008956099.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|675800043|ref|XP_008956100.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|675800045|ref|XP_008956101.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|675800047|ref|XP_008956102.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|675800049|ref|XP_008956103.1| PREDICTED: 60S ribosomal protein L6 [Pan paniscus]>gi|694952159|ref|XP_009424491.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|694952161|ref|XP_009424492.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|694952163|ref|XP_009424493.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|694952165|ref|XP_009424494.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|694952167|ref|XP_009424495.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|694952169|ref|XP_009424496.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|694952171|ref|XP_009424497.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Pan troglodytes]>gi|767975056|ref|XP_011536948.1| PREDICTED: 60S ribosomal protein L6 isoform X1 [Homo sapiens]>gi|1350762|sp|Q02878.3|RL6_HUMAN RecName: Full=60S ribosomal protein L6; AltName: Full=Neoplasm-related protein C140; AltName: Full=Tax-responsive enhancer element-binding protein 107; Short=TaxREB107>gi|485601464|pdb|3J3B|E Chain E, Structure Of The Human 60s Ribosomal Proteins>gi|665764263|pdb|4CXD|E Chain E, Regulation Of The Mammalian Elongation Cycle By 40s Subunit Rolling: A Eukaryotic-specific Ribosome Rearrangement>gi|433416|dbj|BAA04491.1| DNA-binding protein TAXREB107 [Homo sapiens]>gi|11041628|dbj|BAB17292.1| ribosomal protein L6 [Homo sapiens]>gi|13278717|gb|AAH04138.1| Ribosomal protein L6 [Homo sapiens]>gi|21619024|gb|AAH32299.1| Ribosomal protein L6 [Homo sapiens]>gi|48734984|gb|AAH71912.1| Ribosomal protein L6 [Homo sapiens]>gi|61359052|gb|AAX41661.1| ribosomal protein L6 [synthetic construct]>gi|85397340|gb|AAI04825.1| Ribosomal protein L6 [Homo sapiens]>gi|85397708|gb|AAI04827.1| Ribosomal protein L6 [Homo sapiens]>gi|119618411|gb|EAW98005.1| ribosomal protein L6, isoform CRA_b [Homo sapiens]>gi|119618412|gb|EAW98006.1| ribosomal protein L6, isoform CRA_b [Homo sapiens]>gi|119618413|gb|EAW98007.1| ribosomal protein L6, isoform CRA_b [Homo sapiens]>gi|119618414|gb|EAW98008.1| ribosomal protein L6, isoform CRA_b [Homo sapiens]>gi|119618415|gb|EAW98009.1| ribosomal protein L6, isoform CRA_b [Homo sapiens]>gi|119618416|gb|EAW98010.1| ribosomal protein L6, isoform CRA_b [Homo sapiens]>gi|208967324|dbj|BAG73676.1| ribosomal protein L6 [synthetic construct]>gi|343959774|dbj|BAK63744.1| 60S ribosomal protein L6 [Pan troglodytes]>gi|649102885|gb|AIC49609.1| RPL6, partial [synthetic construct] 767975058 XM_006719549.2 881 0 PREDICTED: Homo sapiens ribosomal protein L6 (RPL6), transcript variant X5, mRNA K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q02878 1158 1.2e-125 60S ribosomal protein L6 OS=Homo sapiens GN=RPL6 PE=1 SV=3 PF03868//PF01159 Ribosomal protein L6, N-terminal domain//Ribosomal protein L6e GO:0006614//GO:0006414//GO:0019083//GO:0000184//GO:0006412//GO:0006355//GO:0006413//GO:0006415//GO:0042254 SRP-dependent cotranslational protein targeting to membrane//translational elongation//viral transcription//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//translation//regulation of transcription, DNA-templated//translational initiation//translational termination//ribosome biogenesis GO:0003723//GO:0003677//GO:0003735 RNA binding//DNA binding//structural constituent of ribosome GO:0022625//GO:0005840//GO:0005622 cytosolic large ribosomal subunit//ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-8309.39400 BF_2 2612.64 22.34 5179 642926169 XP_008194813.1 2776 4.1e-311 PREDICTED: vinculin isoform X3 [Tribolium castaneum] 665389295 NM_001297885.1 65 1.73377e-22 Drosophila melanogaster vinculin (Vinc), transcript variant C, mRNA K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 2024 2.8e-225 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01442//PF09141//PF04513//PF01044 Apolipoprotein A1/A4/E domain//Talin, middle domain//Baculovirus polyhedron envelope protein, PEP, C terminus//Vinculin family GO:0006869//GO:0042157//GO:0007016//GO:0007155 lipid transport//lipoprotein metabolic process//cytoskeletal anchoring at plasma membrane//cell adhesion GO:0005198//GO:0008289//GO:0051015//GO:0005200 structural molecule activity//lipid binding//actin filament binding//structural constituent of cytoskeleton GO:0019031//GO:0005856//GO:0005925//GO:0019028//GO:0001726//GO:0005576 viral envelope//cytoskeleton//focal adhesion//viral capsid//ruffle//extracellular region KOG3681 Alpha-catenin Cluster-8309.39402 BF_2 190.64 2.85 3083 646682520 KDR02319.1 1568 3.0e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 3.59131e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.4e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF07714//PF00937//PF00069 Protein tyrosine kinase//Coronavirus nucleocapsid protein//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.39403 BF_2 27.21 0.47 2707 91085003 XP_973266.1 1283 3.0e-138 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 815925584 XM_012391990.1 107 4.04368e-46 PREDICTED: Bombus impatiens glycogen [starch] synthase (LOC100748309), transcript variant X8, mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 1105 5.3e-119 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF05693 Glycogen synthase GO:0005982//GO:0005978//GO:0005985 starch metabolic process//glycogen biosynthetic process//sucrose metabolic process GO:0004373 glycogen (starch) synthase activity -- -- KOG3742 Glycogen synthase Cluster-8309.39406 BF_2 1554.77 14.83 4674 91086137 XP_968906.1 5668 0.0e+00 PREDICTED: sister chromatid cohesion protein PDS5 homolog B isoform X1 [Tribolium castaneum]>gi|270010223|gb|EFA06671.1| hypothetical protein TcasGA2_TC009599 [Tribolium castaneum] 170044604 XM_001849880.1 125 6.9229e-56 Culex quinquefasciatus androgen induced inhibitor of proliferation / pds5, mRNA K11267 PDS5 sister chromatid cohesion protein PDS5 http://www.genome.jp/dbget-bin/www_bget?ko:K11267 Q5F3U9 2271 5.7e-254 Sister chromatid cohesion protein PDS5 homolog B OS=Gallus gallus GN=PDS5B PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1525 Sister chromatid cohesion complex Cohesin, subunit PDS5 Cluster-8309.39407 BF_2 1363.75 17.66 3518 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 2.43528e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 8.1e-27 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF03526//PF00560//PF13855//PF13895 Colicin E1 (microcin) immunity protein//Leucine Rich Repeat//Leucine rich repeat//Immunoglobulin domain GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.39409 BF_2 164.00 13.12 810 478255265 ENN75494.1 640 3.2e-64 hypothetical protein YQE_08043, partial [Dendroctonus ponderosae] -- -- -- -- -- K14157 AASS alpha-aminoadipic semialdehyde synthase http://www.genome.jp/dbget-bin/www_bget?ko:K14157 A8E657 311 1.9e-27 Alpha-aminoadipic semialdehyde synthase, mitochondrial OS=Bos taurus GN=AASS PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0172 Lysine-ketoglutarate reductase/saccharopine dehydrogenase Cluster-8309.39411 BF_2 2074.11 17.60 5216 642934848 XP_008197836.1 1654 5.5e-181 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 4.46003e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA -- -- -- -- Q5JR59 239 2.7e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39412 BF_2 32.66 0.50 3034 642934848 XP_008197836.1 1619 3.6e-177 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5JR59 239 1.6e-18 Microtubule-associated tumor suppressor candidate 2 OS=Homo sapiens GN=MTUS2 PE=1 SV=3 PF09270 Beta-trefoil DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0000982//GO:0000978 transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.39413 BF_2 273.00 29.37 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39417 BF_2 93.72 2.22 2051 189237332 XP_973384.2 1523 3.3e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 6.7983e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 1.7e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.39418 BF_2 328.65 3.98 3742 189238300 XP_970863.2 4491 0.0e+00 PREDICTED: jmjC domain-containing histone demethylation protein 1 isoform X1 [Tribolium castaneum] 602630683 XM_007422193.1 38 1.27613e-07 PREDICTED: Python bivittatus PHD finger protein 8 (PHF8), transcript variant X4, mRNA K10276 FBXL10_11, KDM2 F-box and leucine-rich repeat protein 10/11 http://www.genome.jp/dbget-bin/www_bget?ko:K10276 Q9VHH9 1629 1.3e-179 JmjC domain-containing histone demethylation protein 1 OS=Drosophila melanogaster GN=Kdm2 PE=1 SV=2 PF16866//PF02008//PF00646//PF12937//PF13855 PHD-finger//CXXC zinc finger domain//F-box domain//F-box-like//Leucine rich repeat -- -- GO:0005515//GO:0003677//GO:0008270 protein binding//DNA binding//zinc ion binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.39420 BF_2 1298.11 6.21 9035 642937658 XP_008198888.1 5149 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 14 [Tribolium castaneum] 157132702 XM_001662569.1 146 2.84532e-67 Aedes aegypti AAEL012490-RA partial mRNA K15156 MED14, RGR1 mediator of RNA polymerase II transcription subunit 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15156 Q16U49 3488 0.0e+00 Mediator of RNA polymerase II transcription subunit 14 OS=Aedes aegypti GN=MED14 PE=3 SV=2 PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1875 Thyroid hormone receptor-associated coactivator complex component (TRAP170) Cluster-8309.39422 BF_2 23.59 0.33 3269 642938766 XP_008199879.1 1179 4.1e-126 PREDICTED: protein transport protein Sec16B-like isoform X4 [Tribolium castaneum]>gi|642938768|ref|XP_008199880.1| PREDICTED: protein transport protein Sec16B-like isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15027 722 1.7e-74 Protein transport protein Sec16A OS=Homo sapiens GN=SEC16A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1913 Regucalcin gene promoter region-related protein (RGPR) Cluster-8309.39423 BF_2 57.47 0.47 5426 642940052 XP_008200969.1 2852 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF00439//PF00004//PF07724//PF07728//PF01695//PF06068//PF05496//PF14722//PF00910//PF00005//PF04851 Bromodomain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Ki-ras-induced actin-interacting protein-IP3R-interacting domain//RNA helicase//ABC transporter//Type III restriction enzyme, res subunit GO:0006310//GO:0007165//GO:0006281 DNA recombination//signal transduction//DNA repair GO:0016887//GO:0005102//GO:0003724//GO:0009378//GO:0016787//GO:0003677//GO:0003723//GO:0005524//GO:0003678//GO:0005515 ATPase activity//receptor binding//RNA helicase activity//four-way junction helicase activity//hydrolase activity//DNA binding//RNA binding//ATP binding//DNA helicase activity//protein binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.39424 BF_2 2728.63 16.57 7176 91081899 XP_976020.1 1589 2.6e-173 PREDICTED: cyclin-Y-like protein 1 [Tribolium castaneum]>gi|270007331|gb|EFA03779.1| hypothetical protein TcasGA2_TC013890 [Tribolium castaneum] 620962625 XM_007667839.1 113 4.99139e-49 PREDICTED: Ornithorhynchus anatinus cyclin Y (CCNY), mRNA K07881 RAB14 Ras-related protein Rab-14 http://www.genome.jp/dbget-bin/www_bget?ko:K07881 Q6NRF4 988 5.2e-105 Cyclin-Y-like protein 1-B OS=Xenopus laevis GN=ccnyl1-b PE=2 SV=1 PF08613//PF01926//PF08477//PF00735//PF00025//PF03193//PF00071//PF04670 Cyclin//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//ADP-ribosylation factor family//Protein of unknown function, DUF258//Ras family//Gtr1/RagA G protein conserved region GO:0000079//GO:0007264 regulation of cyclin-dependent protein serine/threonine kinase activity//small GTPase mediated signal transduction GO:0003924//GO:0019901//GO:0005525 GTPase activity//protein kinase binding//GTP binding -- -- KOG1675 Predicted cyclin Cluster-8309.39426 BF_2 466.00 28.93 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39428 BF_2 95.92 0.92 4649 270010664 EFA07112.1 2150 1.5e-238 hypothetical protein TcasGA2_TC010102 [Tribolium castaneum] -- -- -- -- -- K10297 FBXO11 F-box protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10297 Q7TPD1 1170 2.7e-126 F-box only protein 11 OS=Mus musculus GN=Fbxo11 PE=1 SV=3 PF12937//PF00646//PF15966 F-box-like//F-box domain//F-box -- -- GO:0005515 protein binding -- -- KOG1777 Putative Zn-finger protein Cluster-8309.39429 BF_2 93.40 1.85 2394 91077534 XP_967040.1 304 8.7e-25 PREDICTED: myophilin [Tribolium castaneum]>gi|270001583|gb|EEZ98030.1| hypothetical protein TcasGA2_TC000431 [Tribolium castaneum] 768423547 XM_011554383.1 66 2.21178e-23 PREDICTED: Plutella xylostella muscle-specific protein 20 (LOC105384189), mRNA -- -- -- -- P14318 169 1.6e-10 Muscle-specific protein 20 OS=Drosophila melanogaster GN=Mp20 PE=2 SV=2 -- -- GO:0031032 actomyosin structure organization GO:0003779 actin binding -- -- KOG2046 Calponin Cluster-8309.39430 BF_2 1271.71 25.70 2357 189235871 XP_001811450.1 1667 7.7e-183 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39431 BF_2 1342.00 33.82 1947 195118306 XP_002003681.1 1022 3.9e-108 GI21581 [Drosophila mojavensis]>gi|193914256|gb|EDW13123.1| GI21581 [Drosophila mojavensis] -- -- -- -- -- K15620 GOLPH3, GPP34 golgi phosphoprotein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15620 Q9VQ93 1030 1.9e-110 Golgi phosphoprotein 3 homolog rotini OS=Drosophila melanogaster GN=rti PE=1 SV=1 PF05719 Golgi phosphoprotein 3 (GPP34) GO:0048193 Golgi vesicle transport GO:0070273 phosphatidylinositol-4-phosphate binding -- -- KOG3983 Golgi protein Cluster-8309.39433 BF_2 4989.05 41.91 5267 282165786 NP_001164132.1 560 4.0e-54 cellular FABP-like protein isoform 3 [Tribolium castaneum]>gi|270009254|gb|EFA05702.1| cellular FABP-like protein [Tribolium castaneum] 797056877 HG313989.1 35 8.38043e-06 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 11 K08756 FABP7 fatty acid-binding protein 7, brain http://www.genome.jp/dbget-bin/www_bget?ko:K08756 A6YLM6 280 4.8e-23 Fatty acid-binding protein, adipocyte OS=Cervus elaphus GN=FABP4 PE=2 SV=1 PF02330 Mitochondrial glycoprotein GO:0006810 transport GO:0008289//GO:0005215 lipid binding//transporter activity GO:0005759 mitochondrial matrix KOG4015 Fatty acid-binding protein FABP Cluster-8309.39434 BF_2 32.06 0.73 2128 612015647 XP_007490773.1 466 1.3e-43 PREDICTED: zinc finger protein 347-like isoform X2 [Monodelphis domestica] 642923548 XM_008195332.1 36 9.32589e-07 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZN57 454 1.3e-43 Zinc finger protein 2 homolog OS=Homo sapiens GN=ZFP2 PE=1 SV=1 PF07975//PF13465//PF00096//PF07776//PF02892//PF13912 TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//BED zinc finger//C2H2-type zinc finger GO:0006281 DNA repair GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.39435 BF_2 5963.48 16.38 15515 270010181 EFA06629.1 16316 0.0e+00 hypothetical protein TcasGA2_TC009548 [Tribolium castaneum] -- -- -- -- -- K04550 LRP1, CD91 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) http://www.genome.jp/dbget-bin/www_bget?ko:K04550 P98157 8292 0.0e+00 Low-density lipoprotein receptor-related protein 1 OS=Gallus gallus GN=LRP1 PE=2 SV=1 PF09008//PF00008//PF00057//PF07645//PF06769//PF02022 Head binding//EGF-like domain//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//YoeB-like toxin of bacterial type II toxin-antitoxin system//Integrase Zinc binding domain GO:0006401//GO:0009405 RNA catabolic process//pathogenesis GO:0008270//GO:0004519//GO:0005509//GO:0005515 zinc ion binding//endonuclease activity//calcium ion binding//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.39437 BF_2 2080.87 40.45 2439 478263397 ENN81769.1 862 1.8e-89 hypothetical protein YQE_01862, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NDA2 232 8.2e-18 Hemicentin-2 OS=Homo sapiens GN=HMCN2 PE=2 SV=2 PF01108//PF15491//PF13895//PF00041//PF16656 Tissue factor//CST, telomere maintenance, complex subunit CTC1//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0000723//GO:0019497 riboflavin metabolic process//telomere maintenance//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.39438 BF_2 409.17 2.35 7575 91091124 XP_969500.1 441 3.6e-40 PREDICTED: calcium-binding protein E63-1 [Tribolium castaneum]>gi|642936333|ref|XP_008198399.1| PREDICTED: calcium-binding protein E63-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48593 399 1.1e-36 Calcium-binding protein E63-1 OS=Drosophila melanogaster GN=Eip63F-1 PE=2 SV=2 PF13499//PF13833//PF10591//PF13405//PF12763//PF00036//PF04857//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Cytoskeletal-regulatory complex EF hand//EF hand//CAF1 family ribonuclease//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005634//GO:0005578 nucleus//proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.39439 BF_2 14.17 0.49 1501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39440 BF_2 1753.10 16.88 4632 642927044 XP_008195115.1 1565 1.0e-170 PREDICTED: LOW QUALITY PROTEIN: transmembrane protein 214-B [Tribolium castaneum] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 Q148G4 835 1.9e-87 Putative deoxyribonuclease TATDN1 OS=Bos taurus GN=TATDN1 PE=2 SV=1 PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3020 TatD-related DNase Cluster-8309.39442 BF_2 1390.54 22.36 2889 91090890 XP_973414.1 3738 0.0e+00 PREDICTED: coatomer subunit gamma [Tribolium castaneum]>gi|270013230|gb|EFA09678.1| hypothetical protein TcasGA2_TC011806 [Tribolium castaneum] -- -- -- -- -- K17267 COPG coatomer protein complex, subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K17267 Q29AE5 2925 0.0e+00 Coatomer subunit gamma OS=Drosophila pseudoobscura pseudoobscura GN=gammaCop PE=3 SV=1 PF01602//PF02985//PF08752 Adaptin N terminal region//HEAT repeat//Coatomer gamma subunit appendage platform subdomain GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG1078 Vesicle coat complex COPI, gamma subunit Cluster-8309.39444 BF_2 556.09 7.31 3471 478253971 ENN74263.1 1931 2.8e-213 hypothetical protein YQE_09235, partial [Dendroctonus ponderosae] -- -- -- -- -- K08189 SLC16A13 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08189 Q7RTY0 334 1.7e-29 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF00473//PF05924//PF07690 Corticotropin-releasing factor family//SAMP Motif//Major Facilitator Superfamily GO:0007165//GO:0016055//GO:0055085 signal transduction//Wnt signaling pathway//transmembrane transport GO:0008013//GO:0005179 beta-catenin binding//hormone activity GO:0005576//GO:0016342//GO:0016021 extracellular region//catenin complex//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.39445 BF_2 91.16 0.92 4433 478253971 ENN74263.1 1931 3.5e-213 hypothetical protein YQE_09235, partial [Dendroctonus ponderosae] -- -- -- -- -- K08189 SLC16A13 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08189 Q7RTY0 334 2.2e-29 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF05924//PF07690 SAMP Motif//Major Facilitator Superfamily GO:0016055//GO:0055085 Wnt signaling pathway//transmembrane transport GO:0008013 beta-catenin binding GO:0016021//GO:0016342 integral component of membrane//catenin complex KOG2504 Monocarboxylate transporter Cluster-8309.39448 BF_2 102.78 2.51 1998 91087311 XP_975575.1 1011 7.6e-107 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.7e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF09415//PF01287//PF02269 CENP-S associating Centromere protein X//Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold//Transcription initiation factor IID, 18kD subunit GO:0006281//GO:0006366//GO:0006448//GO:0006452//GO:0051382//GO:0045901//GO:0045905 DNA repair//transcription from RNA polymerase II promoter//regulation of translational elongation//translational frameshifting//kinetochore assembly//positive regulation of translational elongation//positive regulation of translational termination GO:0043022//GO:0003723//GO:0003746 ribosome binding//RNA binding//translation elongation factor activity GO:0005840 ribosome KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.39449 BF_2 730.27 23.25 1601 478254491 ENN74739.1 327 1.3e-27 hypothetical protein YQE_08677, partial [Dendroctonus ponderosae] -- -- -- -- -- K15623 SS18, SSXT, SYT protein SSXT http://www.genome.jp/dbget-bin/www_bget?ko:K15623 O75177 205 7.2e-15 Calcium-responsive transactivator OS=Homo sapiens GN=SS18L1 PE=1 SV=2 PF16035 Chalcone isomerase like -- -- GO:0016872 intramolecular lyase activity -- -- KOG3227 Calcium-responsive transcription coactivator Cluster-8309.39451 BF_2 515.95 4.60 4984 478254062 ENN74354.1 272 9.3e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39452 BF_2 64.66 1.45 2153 91084421 XP_968215.1 1137 2.0e-121 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35502 731 9.9e-76 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06467//PF00326//PF07859 MYM-type Zinc finger with FCS sequence motif//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008270//GO:0008236 hydrolase activity//zinc ion binding//serine-type peptidase activity -- -- -- -- Cluster-8309.39453 BF_2 12375.89 880.71 875 546676497 ERL87495.1 1085 8.7e-116 hypothetical protein D910_04887, partial [Dendroctonus ponderosae] 164683615 EU373305.1 547 0 Monochamus alternatus beta1-tubulin (TubB) mRNA, complete cds K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 1081 1.0e-116 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 PF00091//PF04816 Tubulin/FtsZ family, GTPase domain//tRNA (adenine(22)-N(1))-methyltransferase GO:0008033//GO:0009451 tRNA processing//RNA modification GO:0016429//GO:0003924 tRNA (adenine-N1-)-methyltransferase activity//GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.39454 BF_2 256.09 5.49 2237 91084421 XP_968215.1 1313 8.2e-142 PREDICTED: venom carboxylesterase-6 [Tribolium castaneum]>gi|270008700|gb|EFA05148.1| hypothetical protein TcasGA2_TC015265 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35502 844 8.1e-89 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06467//PF07425//PF00326//PF07859 MYM-type Zinc finger with FCS sequence motif//Pardaxin//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787//GO:0008270 serine-type peptidase activity//hydrolase activity//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.39456 BF_2 904.44 4.47 8745 642927636 XP_008195344.1 4923 0.0e+00 PREDICTED: zinc finger FYVE domain-containing protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGP1 1082 8.0e-116 Zinc finger FYVE domain-containing protein 26 homolog OS=Drosophila melanogaster GN=CG5270 PE=1 SV=3 PF02419//PF01363//PF04805 PsbL protein//FYVE zinc finger//E10-like protein conserved region GO:0055114//GO:0015979 oxidation-reduction process//photosynthesis GO:0046872//GO:0016972 metal ion binding//thiol oxidase activity GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane KOG1811 Predicted Zn2+-binding protein, contains FYVE domain Cluster-8309.39464 BF_2 963.00 130.84 595 270011248 EFA07696.1 152 9.1e-08 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39466 BF_2 262.40 4.78 2583 91087137 XP_975265.1 2140 1.2e-237 PREDICTED: glycosylphosphatidylinositol anchor attachment 1 protein [Tribolium castaneum]>gi|270009591|gb|EFA06039.1| hypothetical protein TcasGA2_TC008869 [Tribolium castaneum] -- -- -- -- -- K05289 GAA1 glycosylphosphatidylinositol transamidase http://www.genome.jp/dbget-bin/www_bget?ko:K05289 O43292 830 3.9e-87 Glycosylphosphatidylinositol anchor attachment 1 protein OS=Homo sapiens GN=GPAA1 PE=1 SV=3 PF02163//PF04114 Peptidase family M50//Gaa1-like, GPI transamidase component GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity GO:0016021//GO:0042765 integral component of membrane//GPI-anchor transamidase complex KOG3566 Glycosylphosphatidylinositol anchor attachment protein GAA1 Cluster-8309.39467 BF_2 473.04 13.91 1710 91087553 XP_970739.1 1460 5.6e-159 PREDICTED: protein farnesyltransferase subunit beta [Tribolium castaneum]>gi|270010683|gb|EFA07131.1| hypothetical protein TcasGA2_TC010122 [Tribolium castaneum] 56758975 AY815896.1 42 3.4479e-10 Schistosoma japonicum SJCHGC09483 protein mRNA, complete cds K05954 FNTB protein farnesyltransferase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K05954 P49356 1044 4.0e-112 Protein farnesyltransferase subunit beta OS=Homo sapiens GN=FNTB PE=1 SV=1 PF00432 Prenyltransferase and squalene oxidase repeat GO:0018343//GO:0042127 protein farnesylation//regulation of cell proliferation GO:0003824 catalytic activity GO:0005965 protein farnesyltransferase complex KOG0365 Beta subunit of farnesyltransferase Cluster-8309.39469 BF_2 23.08 0.69 1695 642928935 XP_008195623.1 1417 5.4e-154 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9VCX1 836 5.2e-88 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF02196//PF00788 Raf-like Ras-binding domain//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- -- -- Cluster-8309.39471 BF_2 230.44 3.96 2722 642917631 XP_008193400.1 1846 1.6e-203 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 967 5.4e-103 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01728//PF01585 FtsJ-like methyltransferase//G-patch domain GO:0032259 methylation GO:0008168//GO:0003676 methyltransferase activity//nucleic acid binding -- -- KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.39475 BF_2 3705.55 20.23 7949 642927516 XP_970801.3 2072 2.8e-229 PREDICTED: RNA-binding protein fusilli isoform X2 [Tribolium castaneum] 170047638 XM_001851269.1 219 6.57348e-108 Culex quinquefasciatus conserved hypothetical protein, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 1080 1.2e-115 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 PF00666//PF12763//PF12356//PF00076 Cathelicidin//Cytoskeletal-regulatory complex EF hand//Protein of unknown function (DUF3643)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006915//GO:0032465//GO:0016567//GO:0006952 apoptotic process//regulation of cytokinesis//protein ubiquitination//defense response GO:0003676//GO:0005515//GO:0004842 nucleic acid binding//protein binding//ubiquitin-protein transferase activity GO:0005576 extracellular region KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.39477 BF_2 239.95 3.15 3469 642927514 XP_008195300.1 2879 0.0e+00 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] 170047638 XM_001851269.1 219 2.85311e-108 Culex quinquefasciatus conserved hypothetical protein, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 1317 1.8e-143 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.39478 BF_2 114.59 0.57 8685 270009943 EFA06391.1 192 3.1e-11 hypothetical protein TcasGA2_TC009269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009//PF00570//PF12763//PF12356//PF06061 Telomerase ribonucleoprotein complex - RNA binding domain//HRDC domain//Cytoskeletal-regulatory complex EF hand//Protein of unknown function (DUF3643)//Baculoviridae ME53 GO:0032465//GO:0006278//GO:0016567//GO:0006915 regulation of cytokinesis//RNA-dependent DNA replication//protein ubiquitination//apoptotic process GO:0003677//GO:0003964//GO:0004842//GO:0005515//GO:0008270//GO:0003676 DNA binding//RNA-directed DNA polymerase activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.39480 BF_2 158.43 0.62 10995 270008334 EFA04782.1 2089 4.2e-231 hypothetical protein TcasGA2_TC030779 [Tribolium castaneum] -- -- -- -- -- K10630 RBCK1, HOIL1 RanBP-type and C3HC4-type zinc finger-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10630 E6ZIJ1 896 3.7e-94 RanBP-type and C3HC4-type zinc finger-containing protein 1 OS=Dicentrarchus labrax GN=rbck1 PE=3 SV=1 PF09174//PF13639//PF14634//PF00641//PF00240//PF00097 Maf1 regulator//Ring finger domain//zinc-RING finger domain//Zn-finger in Ran binding protein and others//Ubiquitin family//Zinc finger, C3HC4 type (RING finger) GO:0016480 negative regulation of transcription from RNA polymerase III promoter GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.39483 BF_2 1197.00 17.52 3146 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39484 BF_2 84.80 0.47 7898 270016510 EFA12956.1 3014 0.0e+00 pumilio [Tribolium castaneum] 642939433 XM_008202167.1 706 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 2.0e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806 CPL (NUC119) domain//Pumilio-family RNA binding repeat -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.39485 BF_2 3262.98 53.34 2846 91093363 XP_969584.1 1352 3.1e-146 PREDICTED: proliferation-associated protein 2G4 [Tribolium castaneum]>gi|270015297|gb|EFA11745.1| hypothetical protein TcasGA2_TC004235 [Tribolium castaneum] 332374437 BT127398.1 224 3.88032e-111 Dendroctonus ponderosae clone DPO1122_M15 unknown mRNA -- -- -- -- Q6AYD3 948 9.0e-101 Proliferation-associated protein 2G4 OS=Rattus norvegicus GN=Pa2g4 PE=1 SV=1 PF01295 Adenylate cyclase, class-I GO:0006144//GO:0006171//GO:0009987 purine nucleobase metabolic process//cAMP biosynthetic process//cellular process GO:0004016 adenylate cyclase activity -- -- KOG2776 Metallopeptidase Cluster-8309.39486 BF_2 1509.01 6.71 9700 642912783 XP_008201250.1 854 5.9e-88 PREDICTED: held out wings isoform X1 [Tribolium castaneum] 645014013 XM_008207131.1 156 8.43583e-73 PREDICTED: Nasonia vitripennis protein held out wings (LOC100120734), mRNA K14945 QKI protein quaking http://www.genome.jp/dbget-bin/www_bget?ko:K14945 O01367 770 1.3e-79 Protein held out wings OS=Drosophila melanogaster GN=how PE=1 SV=1 PF00013//PF13014//PF13103//PF13762 KH domain//KH domain//TonB C terminal//Mitochondrial splicing apparatus component GO:0000372//GO:0006810 Group I intron splicing//transport GO:0003723 RNA binding GO:0030529 intracellular ribonucleoprotein complex KOG1588 RNA-binding protein Sam68 and related KH domain proteins Cluster-8309.39487 BF_2 4795.84 32.94 6377 270016366 EFA12812.1 585 6.1e-57 hypothetical protein TcasGA2_TC001877 [Tribolium castaneum] 642933104 XM_008199038.1 222 1.13216e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 193 7.1e-13 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0000166//GO:0004814 ATP binding//nucleotide binding//arginine-tRNA ligase activity GO:0005737 cytoplasm KOG2945 Predicted RNA-binding protein Cluster-8309.39488 BF_2 1374.88 9.98 6048 642923353 XP_008193715.1 2686 1.4e-300 PREDICTED: glycerophosphocholine phosphodiesterase GPCPD1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q80VJ4 958 1.3e-101 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Rattus norvegicus GN=Gpcpd1 PE=2 SV=1 PF00686//PF03009 Starch binding domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:2001070//GO:0008081 starch binding//phosphoric diester hydrolase activity -- -- KOG2421 Predicted starch-binding protein Cluster-8309.39489 BF_2 84.04 0.81 4624 642916846 XP_008199527.1 814 1.2e-83 PREDICTED: failed axon connections isoform X2 [Tribolium castaneum]>gi|270003072|gb|EEZ99519.1| hypothetical protein TcasGA2_TC000100 [Tribolium castaneum] 642916844 XM_963303.3 271 4.72746e-137 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X1, mRNA -- -- -- -- Q95RI5 693 5.4e-71 Failed axon connections OS=Drosophila melanogaster GN=fax PE=1 SV=1 PF02535//PF06459//PF06213//PF16834//PF02724//PF05132//PF13417 ZIP Zinc transporter//Ryanodine Receptor TM 4-6//Cobalamin biosynthesis protein CobT//Shu complex component Csm2, DNA-binding//CDC45-like protein//RNA polymerase III RPC4//Glutathione S-transferase, N-terminal domain GO:0000725//GO:0006206//GO:0006144//GO:0006351//GO:0030001//GO:0006383//GO:0009236//GO:0006874//GO:0006270//GO:0055085//GO:0006816 recombinational repair//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//metal ion transport//transcription from RNA polymerase III promoter//cobalamin biosynthetic process//cellular calcium ion homeostasis//DNA replication initiation//transmembrane transport//calcium ion transport GO:0046873//GO:0005219//GO:0005515//GO:0003677//GO:0003899 metal ion transmembrane transporter activity//ryanodine-sensitive calcium-release channel activity//protein binding//DNA binding//DNA-directed RNA polymerase activity GO:0097196//GO:0016020//GO:0005634//GO:0005666//GO:0005730//GO:0005622//GO:0016021 Shu complex//membrane//nucleus//DNA-directed RNA polymerase III complex//nucleolus//intracellular//integral component of membrane -- -- Cluster-8309.39490 BF_2 87.97 0.66 5825 332375456 AEE62869.1 2168 1.5e-240 unknown [Dendroctonus ponderosae]>gi|478252256|gb|ENN72684.1| hypothetical protein YQE_10780, partial [Dendroctonus ponderosae]>gi|546674429|gb|ERL85807.1| hypothetical protein D910_03223 [Dendroctonus ponderosae] 170043460 XM_001849353.1 149 3.93581e-69 Culex quinquefasciatus pyruvate kinase, mRNA K00873 PK, pyk pyruvate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00873 O62619 1817 3.2e-201 Pyruvate kinase OS=Drosophila melanogaster GN=PyK PE=2 SV=2 PF00478//PF00224//PF03328 IMP dehydrogenase / GMP reductase domain//Pyruvate kinase, barrel domain//HpcH/HpaI aldolase/citrate lyase family GO:0006094//GO:0015976//GO:0055114//GO:0006096//GO:0006144 gluconeogenesis//carbon utilization//oxidation-reduction process//glycolytic process//purine nucleobase metabolic process GO:0000287//GO:0003824//GO:0030955//GO:0004743 magnesium ion binding//catalytic activity//potassium ion binding//pyruvate kinase activity -- -- KOG2323 Pyruvate kinase Cluster-8309.39493 BF_2 1899.80 13.33 6250 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 2.9e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF00005//PF03193//PF13304//PF02367//PF01926 SRP54-type protein, GTPase domain//ABC transporter//Protein of unknown function, DUF258//AAA domain, putative AbiEii toxin, Type IV TA system//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase GO:0006614//GO:0002949//GO:0006200 SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification//obsolete ATP catabolic process GO:0016887//GO:0005525//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATP binding//GTPase activity -- -- -- -- Cluster-8309.39494 BF_2 4909.98 49.38 4447 189238710 XP_969341.2 3021 0.0e+00 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 642927019 XM_964248.3 155 1.38544e-72 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q86VQ3 216 1.1e-15 Thioredoxin domain-containing protein 2 OS=Homo sapiens GN=TXNDC2 PE=2 SV=4 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.39495 BF_2 71.02 0.70 4534 189238710 XP_969341.2 3029 0.0e+00 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] 642927019 XM_964248.3 155 1.41276e-72 PREDICTED: Tribolium castaneum titin (LOC657813), mRNA -- -- -- -- Q86VQ3 216 1.1e-15 Thioredoxin domain-containing protein 2 OS=Homo sapiens GN=TXNDC2 PE=2 SV=4 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.39498 BF_2 81.04 0.88 4130 642922280 XP_008193091.1 2505 9.1e-280 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.9e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.39499 BF_2 50.49 0.79 2974 288869514 NP_001165864.1 1669 5.7e-183 extended synaptotagmin-like protein 2a [Tribolium castaneum]>gi|642923659|ref|XP_008193831.1| PREDICTED: extended synaptotagmin-like protein 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5FWL4 697 1.2e-71 Extended synaptotagmin-2-A OS=Xenopus laevis GN=esyt2-a PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.39500 BF_2 96.45 1.46 3053 270007722 EFA04170.1 2265 4.5e-252 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 801 1.1e-83 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.39505 BF_2 972.25 18.98 2430 478263612 ENN81918.1 2067 3.3e-229 hypothetical protein YQE_01630, partial [Dendroctonus ponderosae] 768432559 XM_011559308.1 120 2.15221e-53 PREDICTED: Plutella xylostella succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (LOC105388405), mRNA K01027 OXCT 3-oxoacid CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K01027 Q9D0K2 1654 1.0e-182 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus GN=Oxct1 PE=1 SV=1 PF00816//PF01144 H-NS histone family//Coenzyme A transferase GO:0008152//GO:0006355 metabolic process//regulation of transcription, DNA-templated GO:0003677//GO:0008410 DNA binding//CoA-transferase activity GO:0005622 intracellular KOG3822 Succinyl-CoA:alpha-ketoacid-CoA transferase Cluster-8309.39509 BF_2 11490.10 42.94 11481 270014673 EFA11121.1 14721 0.0e+00 hypothetical protein TcasGA2_TC004721 [Tribolium castaneum] 642911110 XM_008202361.1 2855 0 PREDICTED: Tribolium castaneum projectin (LOC660154), transcript variant X10, mRNA -- -- -- -- Q23551 6850 0.0e+00 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF16794//PF15170//PF01891//PF01108//PF16656//PF01300//PF13895//PF00041 Fibronectin-III type domain//Calcium/calmodulin-dependent protein kinase II inhibitor//Cobalt uptake substrate-specific transmembrane region//Tissue factor//Purple acid Phosphatase, N-terminal domain//Telomere recombination//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0045859//GO:0006771//GO:0000041 hexachlorocyclohexane metabolic process//regulation of protein kinase activity//riboflavin metabolic process//transition metal ion transport GO:0005515//GO:0004860//GO:0046872//GO:0003725//GO:0003993 protein binding//protein kinase inhibitor activity//metal ion binding//double-stranded RNA binding//acid phosphatase activity GO:0016021 integral component of membrane KOG0613 Projectin/twitchin and related proteins Cluster-8309.3951 BF_2 2.00 0.38 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P32542 123 7.4e-06 Pol polyprotein OS=Equine infectious anemia virus (isolate CL22) GN=pol PE=1 SV=1 PF00692 dUTPase GO:0046080 dUTP metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.39510 BF_2 77.02 0.45 7463 642935862 XP_008198202.1 2012 2.4e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 9.12923e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 3.9e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF00638//PF02064//PF13181//PF00400//PF13371//PF13374//PF00515//PF13414//PF13176 RanBP1 domain//MAS20 protein import receptor//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0006605//GO:0006886//GO:0046907 protein targeting//intracellular protein transport//intracellular transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.39511 BF_2 483.73 19.09 1347 642915333 XP_008190576.1 291 1.6e-23 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K05465 ANGPT1 angiopoietin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05465 O18920 240 5.3e-19 Angiopoietin-1 OS=Bos taurus GN=ANGPT1 PE=2 SV=3 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex -- -- Cluster-8309.39512 BF_2 302.62 1.01 12781 642918534 XP_008191512.1 3762 0.0e+00 PREDICTED: titin [Tribolium castaneum] 642918533 XM_008193290.1 45 5.63484e-11 PREDICTED: Tribolium castaneum titin (LOC660533), mRNA -- -- -- -- Q9I7U4 1239 7.3e-134 Titin OS=Drosophila melanogaster GN=sls PE=1 SV=3 PF02383//PF05461//PF13895 SacI homology domain//Apolipoprotein L//Immunoglobulin domain GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289//GO:0042578 protein binding//lipid binding//phosphoric ester hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.39513 BF_2 553.01 1.77 13322 478257788 ENN77931.1 3797 0.0e+00 hypothetical protein YQE_05608, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 435 1.3e-40 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF10034//PF00023//PF10510//PF13606 Q-cell neuroblast polarisation//Ankyrin repeat//Phosphatidylinositol-glycan biosynthesis class S protein//Ankyrin repeat GO:0016255 attachment of GPI anchor to protein GO:0005515 protein binding GO:0016021//GO:0042765 integral component of membrane//GPI-anchor transamidase complex -- -- Cluster-8309.39514 BF_2 517.60 10.85 2283 91077394 XP_975293.1 2103 2.1e-233 PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|642913902|ref|XP_008201207.1| PREDICTED: importin subunit alpha-5 [Tribolium castaneum]>gi|270001645|gb|EEZ98092.1| hypothetical protein TcasGA2_TC000505 [Tribolium castaneum] -- -- -- -- -- K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 P52170 1420 1.3e-155 Importin subunit alpha-5 OS=Xenopus laevis GN=kpna1 PE=1 SV=2 PF02985//PF10508//PF01749//PF00514//PF11698//PF01602 HEAT repeat//Proteasome non-ATPase 26S subunit//Importin beta binding domain//Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region GO:0016192//GO:0006886//GO:0015991//GO:0015031//GO:0006606//GO:0043248 vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport//protein transport//protein import into nucleus//proteasome assembly GO:0005515//GO:0016820//GO:0008565 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein transporter activity GO:0000221//GO:0005634//GO:0030117//GO:0005737 vacuolar proton-transporting V-type ATPase, V1 domain//nucleus//membrane coat//cytoplasm KOG0166 Karyopherin (importin) alpha Cluster-8309.39515 BF_2 800.39 13.12 2839 91087269 XP_975538.1 1849 7.3e-204 PREDICTED: acyl-CoA synthetase family member 3, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18660 ACSF3 malonyl-CoA/methylmalonyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K18660 Q3URE1 1113 6.6e-120 Acyl-CoA synthetase family member 3, mitochondrial OS=Mus musculus GN=Acsf3 PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.39516 BF_2 55.31 0.65 3825 189239444 XP_001815329.1 163 3.1e-08 PREDICTED: E3 ubiquitin-protein ligase sina [Tribolium castaneum]>gi|270009612|gb|EFA06060.1| hypothetical protein TcasGA2_TC008895 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145//PF02176 Seven in absentia protein family//TRAF-type zinc finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.39518 BF_2 503.00 31.13 963 270004992 EFA01440.1 391 2.9e-35 hypothetical protein TcasGA2_TC030701, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39519 BF_2 995.01 10.86 4119 270007410 EFA03858.1 1820 2.4e-200 hypothetical protein TcasGA2_TC013974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.3952 BF_2 2.00 1.21 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39523 BF_2 1116.64 25.13 2146 91078182 XP_967647.1 1863 1.3e-205 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCI6 958 4.7e-102 Beta-galactosidase-1-like protein 3 OS=Homo sapiens GN=GLB1L3 PE=2 SV=3 PF00701//PF02449 Dihydrodipicolinate synthetase family//Beta-galactosidase GO:0046486//GO:0005975//GO:0006687//GO:0006012//GO:0008152//GO:0006027 glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//galactose metabolic process//metabolic process//glycosaminoglycan catabolic process GO:0016829//GO:0004565//GO:0004553 lyase activity//beta-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.39525 BF_2 316.04 9.38 1697 642939897 XP_008200232.1 157 6.9e-08 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39529 BF_2 856.60 7.92 4813 642939895 XP_008200229.1 2108 1.1e-233 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] 657546453 XM_008280188.1 50 3.51061e-14 PREDICTED: Stegastes partitus protein tyrosine phosphatase, non-receptor type 6 (ptpn6), mRNA K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q90687 1394 2.9e-152 Tyrosine-protein phosphatase non-receptor type 11 OS=Gallus gallus GN=PTPN11 PE=2 SV=1 PF00102//PF00782//PF03832 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//WSK motif GO:0006570//GO:0006470//GO:0007165//GO:0006605 tyrosine metabolic process//protein dephosphorylation//signal transduction//protein targeting GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes Cluster-8309.39533 BF_2 205.11 3.64 2643 546681897 ERL91906.1 674 1.2e-67 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 347 4.1e-31 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39534 BF_2 77.17 1.09 3244 642929001 XP_008195650.1 2717 1.9e-304 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 966 8.4e-103 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF05986//PF08686 ADAM-TS Spacer 1//PLAC (protease and lacunin) domain -- -- GO:0008233//GO:0004222 peptidase activity//metalloendopeptidase activity GO:0031012 extracellular matrix -- -- Cluster-8309.39536 BF_2 6733.35 88.80 3459 642925269 XP_008194486.1 2058 5.2e-228 PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|642925271|ref|XP_008194487.1| PREDICTED: protein I'm not dead yet [Tribolium castaneum]>gi|270008744|gb|EFA05192.1| hypothetical protein TcasGA2_TC015325 [Tribolium castaneum] -- -- -- -- -- K14445 SLC13A2_3_5 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2/3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14445 Q9VVT2 1133 3.9e-122 Protein I'm not dead yet OS=Drosophila melanogaster GN=Indy PE=1 SV=2 PF01542//PF03600//PF00939 Hepatitis C virus core protein//Citrate transporter//Sodium:sulfate symporter transmembrane region GO:0006810//GO:0055085//GO:0006814 transport//transmembrane transport//sodium ion transport GO:0005198//GO:0005215 structural molecule activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1281 Na+/dicarboxylate, Na+/tricarboxylate and phosphate transporters Cluster-8309.39537 BF_2 4287.05 63.11 3129 91087875 XP_969719.1 1282 4.5e-138 PREDICTED: 14-3-3 protein epsilon [Tribolium castaneum]>gi|270012013|gb|EFA08461.1| hypothetical protein TcasGA2_TC006109 [Tribolium castaneum] 346713643 AK386529.1 334 3.03304e-172 Bombyx mori mRNA, clone: fprW12H08 K06630 YWHAE 14-3-3 protein epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K06630 P92177 1166 5.2e-126 14-3-3 protein epsilon OS=Drosophila melanogaster GN=14-3-3epsilon PE=1 SV=2 PF13181//PF08038//PF00060 Tetratricopeptide repeat//TOM7 family//Ligand-gated ion channel GO:0007165//GO:0030150//GO:0007268//GO:0006811 signal transduction//protein import into mitochondrial matrix//synaptic transmission//ion transport GO:0019904//GO:0005515//GO:0004970 protein domain specific binding//protein binding//ionotropic glutamate receptor activity GO:0016020//GO:0005742 membrane//mitochondrial outer membrane translocase complex KOG0841 Multifunctional chaperone (14-3-3 family) Cluster-8309.39538 BF_2 696.22 25.62 1424 818214314 AKG26772.1 1091 2.9e-116 peroxiredoxin 1 [Dastarcus helophoroides] 665815945 XM_008558436.1 97 7.61922e-41 PREDICTED: Microplitis demolitor peroxiredoxin-2 (LOC103577681), partial mRNA K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9BGI2 934 1.9e-99 Peroxiredoxin-4 OS=Bos taurus GN=PRDX4 PE=2 SV=1 PF10417//PF00578//PF08534 C-terminal domain of 1-Cys peroxiredoxin//AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0051920//GO:0016209//GO:0016491 peroxiredoxin activity//antioxidant activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.39539 BF_2 160.29 3.05 2487 820805560 AKG92771.1 1543 1.9e-168 daugherless [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P51514 146 7.8e-08 Transcription factor 12 OS=Rattus norvegicus GN=Tcf12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39541 BF_2 236.46 0.91 11142 642911559 XP_970343.3 4078 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 280 1.13583e-141 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 3196 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF08074//PF03808//PF00640//PF04689//PF00176//PF01874 CHDCT2 (NUC038) domain//Glycosyl transferase WecB/TagA/CpsF family//Phosphotyrosine interaction domain (PTB/PID)//DNA binding protein S1FA//SNF2 family N-terminal domain//ATP:dephospho-CoA triphosphoribosyl transferase GO:0016310//GO:0009058//GO:0006355 phosphorylation//biosynthetic process//regulation of transcription, DNA-templated GO:0046917//GO:0005515//GO:0003677//GO:0005524//GO:0016818//GO:0008270 triphosphoribosyl-dephospho-CoA synthase activity//protein binding//DNA binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.39544 BF_2 26.51 0.87 1557 91090428 XP_971598.1 612 1.1e-60 PREDICTED: THO complex subunit 4 [Tribolium castaneum]>gi|270013379|gb|EFA09827.1| hypothetical protein TcasGA2_TC011974 [Tribolium castaneum] -- -- -- -- -- K12881 THOC4, ALY THO complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12881 Q58EA2 383 1.6e-35 THO complex subunit 4-A OS=Xenopus laevis GN=alyref-a PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0097159//GO:1901363//GO:0003676 organic cyclic compound binding//heterocyclic compound binding//nucleic acid binding -- -- KOG0533 RRM motif-containing protein Cluster-8309.39545 BF_2 651.13 11.70 2616 91092368 XP_971937.1 2300 3.4e-256 PREDICTED: dnaJ homolog dnj-5 [Tribolium castaneum] -- -- -- -- -- K09534 DNAJC14 DnaJ homolog subfamily C member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09534 Q921R4 425 3.7e-40 DnaJ homolog subfamily C member 14 OS=Mus musculus GN=Dnajc14 PE=2 SV=2 PF05390 Yeast cell wall synthesis protein KRE9/KNH1 GO:0042546//GO:0006078 cell wall biogenesis//(1->6)-beta-D-glucan biosynthetic process -- -- -- -- KOG0720 Molecular chaperone (DnaJ superfamily) Cluster-8309.39546 BF_2 3.88 0.58 569 642928815 XP_967995.2 308 7.1e-26 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 142 5.2e-08 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39547 BF_2 14.37 0.60 1297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39548 BF_2 191.58 4.88 1928 546679644 ERL90075.1 1681 1.5e-184 hypothetical protein D910_07430, partial [Dendroctonus ponderosae] 815900771 XM_012381089.1 72 8.1994e-27 PREDICTED: Bombus impatiens lateral signaling target protein 2 homolog (LOC100747478), transcript variant X2, mRNA -- -- -- -- B0WAQ0 1043 5.9e-112 Lateral signaling target protein 2 homolog OS=Culex quinquefasciatus GN=CPIJ004116 PE=3 SV=1 PF02347 Glycine cleavage system P-protein GO:0006563//GO:0006566//GO:0006544//GO:0006546//GO:0055114 L-serine metabolic process//threonine metabolic process//glycine metabolic process//glycine catabolic process//oxidation-reduction process GO:0004375 glycine dehydrogenase (decarboxylating) activity -- -- KOG1819 FYVE finger-containing proteins Cluster-8309.39549 BF_2 505.16 12.79 1940 741829513 AJA91072.1 1304 7.8e-141 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 852 8.3e-90 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.39550 BF_2 146.83 6.17 1282 642938930 XP_008200093.1 1123 5.0e-120 PREDICTED: LOW QUALITY PROTEIN: probable cytochrome P450 6a23 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 737 1.2e-76 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF04608//PF01040//PF00067//PF15681 Phosphatidylglycerophosphatase A//UbiA prenyltransferase family//Cytochrome P450//Lymphocyte activation family X GO:0006629//GO:0055114//GO:0046486//GO:0051249//GO:0006955 lipid metabolic process//oxidation-reduction process//glycerolipid metabolic process//regulation of lymphocyte activation//immune response GO:0016705//GO:0004659//GO:0020037//GO:0008962//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//prenyltransferase activity//heme binding//phosphatidylglycerophosphatase activity//iron ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.39552 BF_2 86.64 1.05 3742 270011110 EFA07558.1 1124 1.1e-119 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 764 2.6e-79 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF08367//PF02949 Trypsin//Peptidase M16C associated//7tm Odorant receptor GO:0007187//GO:0006508//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//proteolysis//sensory perception of smell GO:0005549//GO:0004252//GO:0004984 odorant binding//serine-type endopeptidase activity//olfactory receptor activity GO:0016020 membrane -- -- Cluster-8309.39554 BF_2 309.51 6.98 2143 642912940 XP_008201316.1 286 9.6e-23 PREDICTED: antichymotrypsin-2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P48594 220 1.8e-16 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 PF09175 Domain of unknown function (DUF1944) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- -- -- Cluster-8309.39556 BF_2 567.68 3.55 6968 512885476 XP_004921601.1 4075 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX8 [Bombyx mori] 817212638 XM_012427088.1 642 0 PREDICTED: Orussus abietinus ATP-dependent RNA helicase DHX8 (LOC105700863), mRNA K12818 DHX8, PRP22 ATP-dependent RNA helicase DHX8/PRP22 http://www.genome.jp/dbget-bin/www_bget?ko:K12818 A2A4P0 3623 0.0e+00 ATP-dependent RNA helicase DHX8 OS=Mus musculus GN=Dhx8 PE=2 SV=1 PF00575//PF04408//PF14532//PF00005//PF00437//PF07652//PF00270 S1 RNA binding domain//Helicase associated domain (HA2)//Sigma-54 interaction domain//ABC transporter//Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0006355//GO:0006810//GO:0019079 regulation of transcription, DNA-templated//transport//viral genome replication GO:0016887//GO:0003676//GO:0008026//GO:0008134//GO:0004386//GO:0005524 ATPase activity//nucleic acid binding//ATP-dependent helicase activity//transcription factor binding//helicase activity//ATP binding GO:0005667 transcription factor complex KOG0922 DEAH-box RNA helicase Cluster-8309.39557 BF_2 399.29 7.77 2437 100811805 BAE94685.1 2502 1.2e-279 juvenile hormone esterase [Psacothea hilaris] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 748 1.2e-77 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.39558 BF_2 112.00 3.17 1764 478258622 ENN78672.1 343 1.9e-29 hypothetical protein YQE_04844, partial [Dendroctonus ponderosae]>gi|546685778|gb|ERL95227.1| hypothetical protein D910_12494 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q502E5 173 4.1e-11 Small integral membrane protein 8 OS=Danio rerio GN=smim8 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39559 BF_2 5875.40 113.95 2444 642921188 XP_008192753.1 1063 8.7e-113 PREDICTED: reticulon-1-A-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0T0 483 6.4e-47 Reticulon-1 OS=Mus musculus GN=Rtn1 PE=1 SV=1 PF00834 Ribulose-phosphate 3 epimerase family GO:0005975 carbohydrate metabolic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG1792 Reticulon Cluster-8309.39560 BF_2 35.12 0.36 4352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39565 BF_2 2.55 0.39 564 91087491 XP_968373.1 358 1.1e-31 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] -- -- -- -- -- K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 Q5RES5 266 2.1e-22 3-ketoacyl-CoA thiolase, mitochondrial OS=Pongo abelii GN=ACAA2 PE=2 SV=1 PF05923//PF00108 APC cysteine-rich region//Thiolase, N-terminal domain GO:0016055//GO:0008152 Wnt signaling pathway//metabolic process GO:0016747//GO:0016746 transferase activity, transferring acyl groups other than amino-acyl groups//transferase activity, transferring acyl groups -- -- KOG1391 Acetyl-CoA acetyltransferase Cluster-8309.39566 BF_2 1062.82 8.36 5606 91087491 XP_968373.1 1415 3.0e-153 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] 462366872 APGK01027093.1 51 1.13811e-14 Dendroctonus ponderosae Seq01027103, whole genome shotgun sequence K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 P42765 1078 1.5e-115 3-ketoacyl-CoA thiolase, mitochondrial OS=Homo sapiens GN=ACAA2 PE=1 SV=2 PF05699//PF02803//PF00108 hAT family C-terminal dimerisation region//Thiolase, C-terminal domain//Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016747//GO:0046983 transferase activity, transferring acyl groups other than amino-acyl groups//protein dimerization activity -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.39567 BF_2 38.00 8.45 475 91087491 XP_968373.1 177 9.2e-11 PREDICTED: 3-ketoacyl-CoA thiolase, mitochondrial [Tribolium castaneum]>gi|270009465|gb|EFA05913.1| hypothetical protein TcasGA2_TC008729 [Tribolium castaneum] -- -- -- -- -- K07508 ACAA2 acetyl-CoA acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07508 Q3T0R7 141 5.6e-08 3-ketoacyl-CoA thiolase, mitochondrial OS=Bos taurus GN=ACAA2 PE=2 SV=1 PF02803 Thiolase, C-terminal domain GO:0008152 metabolic process GO:0003824//GO:0016747 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1391 Acetyl-CoA acetyltransferase Cluster-8309.39568 BF_2 2407.05 28.18 3860 91077138 XP_971446.1 1025 3.5e-108 PREDICTED: dnaJ homolog subfamily A member 1 [Tribolium castaneum]>gi|270001716|gb|EEZ98163.1| hypothetical protein TcasGA2_TC000590 [Tribolium castaneum] 817197334 XM_012418859.1 104 2.69346e-44 PREDICTED: Orussus abietinus dnaJ homolog subfamily A member 1 (LOC105696421), transcript variant X2, mRNA K09502 DNAJA1 DnaJ homolog subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09502 P63037 769 7.0e-80 DnaJ homolog subfamily A member 1 OS=Mus musculus GN=Dnaja1 PE=1 SV=1 PF00018//PF05209//PF00684//PF16685//PF01155 SH3 domain//Septum formation inhibitor MinC, N-terminal domain//DnaJ central domain//zinc RING finger of MSL2//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006260//GO:0051302//GO:0006457//GO:0006464//GO:0009408 DNA replication//regulation of cell division//protein folding//cellular protein modification process//response to heat GO:0051082//GO:0046872//GO:0005524//GO:0031072//GO:0005515//GO:0016151//GO:0061630 unfolded protein binding//metal ion binding//ATP binding//heat shock protein binding//protein binding//nickel cation binding//ubiquitin protein ligase activity GO:0005737 cytoplasm KOG0712 Molecular chaperone (DnaJ superfamily) Cluster-8309.39569 BF_2 711.83 7.97 4023 642918588 XP_008197437.1 1427 8.9e-155 PREDICTED: RNA-binding Raly-like protein [Tribolium castaneum] 642918587 XM_008199215.1 344 1.07938e-177 PREDICTED: Tribolium castaneum RNA-binding Raly-like protein (LOC103314137), mRNA -- -- -- -- P19600 314 4.2e-27 Heterogeneous nuclear ribonucleoprotein C OS=Xenopus laevis GN=hnrnpc PE=2 SV=1 PF00096//PF00076 Zinc finger, C2H2 type//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- -- -- Cluster-8309.39570 BF_2 27.37 0.35 3537 642918588 XP_008197437.1 640 1.4e-63 PREDICTED: RNA-binding Raly-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.39571 BF_2 532.32 2.19 10456 817062178 XP_012252729.1 10789 0.0e+00 PREDICTED: teneurin-m isoform X4 [Athalia rosae] 642919996 XM_008193938.1 2065 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 9840 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF01436//PF07442 NHL repeat//Ponericin -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.39573 BF_2 36.99 0.75 2352 91085467 XP_970131.1 1348 7.5e-146 PREDICTED: guanine nucleotide-binding protein subunit beta-1 [Tribolium castaneum]>gi|270008384|gb|EFA04832.1| hypothetical protein TcasGA2_TC014882 [Tribolium castaneum] 241655454 XM_002411339.1 361 0 Ixodes scapularis THO complex subunit, putative, mRNA K04538 GNB4 guanine nucleotide-binding protein subunit beta-4 http://www.genome.jp/dbget-bin/www_bget?ko:K04538 O45040 1289 2.1e-140 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homarus americanus GN=GBETA1 PE=2 SV=1 PF03347//PF00400 Vibrio thermostable direct hemolysin//WD domain, G-beta repeat GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515 protein binding GO:0005576 extracellular region KOG0286 G-protein beta subunit Cluster-8309.39574 BF_2 3867.01 89.09 2103 91085467 XP_970131.1 1800 2.6e-198 PREDICTED: guanine nucleotide-binding protein subunit beta-1 [Tribolium castaneum]>gi|270008384|gb|EFA04832.1| hypothetical protein TcasGA2_TC014882 [Tribolium castaneum] 241655454 XM_002411339.1 446 0 Ixodes scapularis THO complex subunit, putative, mRNA K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 P26308 1710 2.9e-189 Guanine nucleotide-binding protein subunit beta-1 OS=Drosophila melanogaster GN=Gbeta13F PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.39575 BF_2 1475.00 76.48 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39576 BF_2 34.99 0.49 3257 478254710 ENN74951.1 1410 6.7e-153 hypothetical protein YQE_08528, partial [Dendroctonus ponderosae] -- -- -- -- -- K12172 RANBP2, NUP358 E3 SUMO-protein ligase RanBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12172 Q9ERU9 363 7.0e-33 E3 SUMO-protein ligase RanBP2 OS=Mus musculus GN=Ranbp2 PE=1 SV=2 PF08777//PF00638//PF00641 RNA binding motif//RanBP1 domain//Zn-finger in Ran binding protein and others GO:0046907 intracellular transport GO:0008270//GO:0003723 zinc ion binding//RNA binding -- -- KOG0864 Ran-binding protein RANBP1 and related RanBD domain proteins Cluster-8309.39579 BF_2 450.56 3.57 5567 91091668 XP_971563.1 1168 1.3e-124 PREDICTED: docking protein 2 [Tribolium castaneum]>gi|270001055|gb|EEZ97502.1| hypothetical protein TcasGA2_TC011346 [Tribolium castaneum] -- -- -- -- -- K17808 ZIM17, DNLZ, Tim15 mitochondrial protein import protein ZIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17808 A1L1P7 281 3.9e-23 DNL-type zinc finger protein OS=Danio rerio GN=dnlz PE=2 SV=1 PF05180//PF02174 DNL zinc finger//PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0008270//GO:0005158 zinc ion binding//insulin receptor binding GO:0005899 insulin receptor complex KOG3277 Uncharacterized conserved protein Cluster-8309.39580 BF_2 81.40 1.29 2931 91080237 XP_972872.1 1006 4.2e-106 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39581 BF_2 2.00 2.34 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39582 BF_2 154.51 1.78 3918 805759384 XP_012151679.1 1174 1.9e-125 PREDICTED: protein KRI1 homolog [Megachile rotundata] 820856991 XR_001112512.1 101 1.27215e-42 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA K14786 KRI1 protein KRI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14786 Q9VTU0 552 1.0e-54 Protein KRI1 homolog OS=Drosophila melanogaster GN=CG5645 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2409 KRR1-interacting protein involved in 40S ribosome biogenesis Cluster-8309.39583 BF_2 2.00 0.97 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39584 BF_2 122.93 17.03 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10798 Biofilm development protein YmgB/AriR GO:0042710//GO:0071229 biofilm formation//cellular response to acid chemical -- -- -- -- -- -- Cluster-8309.39587 BF_2 20.00 0.41 2336 391332716 XP_003740776.1 1602 2.6e-175 PREDICTED: polyadenylate-binding protein 1-like [Metaseiulus occidentalis] 170044608 XM_001849882.1 216 8.89998e-107 Culex quinquefasciatus polyadenylate-binding protein 1, mRNA K13126 PABPC polyadenylate-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13126 Q9EPH8 1443 3.0e-158 Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1 PF00076//PF00658//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Poly-adenylate binding protein, unique domain//RNA recognition motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-8309.39589 BF_2 2101.84 16.57 5593 642917537 XP_008191245.1 5996 0.0e+00 PREDICTED: protein TANC2 isoform X2 [Tribolium castaneum]>gi|642917539|ref|XP_008191246.1| PREDICTED: protein TANC2 isoform X2 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.12745e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.0e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13639//PF13414//PF02376//PF01637//PF00023//PF00004//PF13606//PF00097//PF07728 Ring finger domain//TPR repeat//CUT domain//Archaeal ATPase//Ankyrin repeat//ATPase family associated with various cellular activities (AAA)//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//AAA domain (dynein-related subfamily) -- -- GO:0016887//GO:0003677//GO:0008270//GO:0005524//GO:0005515//GO:0046872 ATPase activity//DNA binding//zinc ion binding//ATP binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.39590 BF_2 323.43 26.18 804 478255719 ENN75928.1 664 5.3e-67 hypothetical protein YQE_07465, partial [Dendroctonus ponderosae]>gi|546681163|gb|ERL91307.1| hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35502 182 1.7e-12 Esterase FE4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39591 BF_2 341.00 6.90 2355 546678047 ERL88771.1 502 9.4e-48 hypothetical protein D910_06153 [Dendroctonus ponderosae] -- -- -- -- -- K01277 DPP3 dipeptidyl-peptidase III http://www.genome.jp/dbget-bin/www_bget?ko:K01277 Q9VHR8 324 1.7e-28 Dipeptidyl peptidase 3 OS=Drosophila melanogaster GN=DppIII PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3675 Dipeptidyl peptidase III Cluster-8309.39592 BF_2 313.43 0.89 15016 642914247 XP_008201606.1 18680 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10171 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF07645//PF00008//PF00028 Calcium-binding EGF domain//EGF-like domain//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.39595 BF_2 380.31 2.89 5783 270006025 EFA02473.1 1249 5.6e-134 hypothetical protein TcasGA2_TC008164 [Tribolium castaneum] -- -- -- -- -- K14803 PTC2_3 protein phosphatase 2C homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14803 P49596 1031 4.3e-110 Probable protein phosphatase 2C T23F11.1 OS=Caenorhabditis elegans GN=ppm-2 PE=3 SV=2 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.39596 BF_2 515.74 6.52 3594 642919707 XP_008192031.1 344 3.0e-29 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 [Tribolium castaneum] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 312 6.4e-27 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-8309.39597 BF_2 42.00 5.07 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39598 BF_2 62.08 4.70 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39599 BF_2 412.00 4.92 3793 642933627 XP_008197501.1 1527 2.1e-166 PREDICTED: phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2 [Tribolium castaneum] 676386870 XM_009038466.1 51 7.67666e-15 Aureococcus anophagefferens hypothetical protein partial mRNA K01110 PTEN phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN http://www.genome.jp/dbget-bin/www_bget?ko:K01110 P60484 854 9.5e-90 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN OS=Homo sapiens GN=PTEN PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004721//GO:0008138//GO:0004725 phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG2283 Clathrin coat dissociation kinase GAK/PTEN/Auxilin and related tyrosine phosphatases Cluster-8309.39601 BF_2 8039.91 81.28 4425 259013492 NP_001158490.1 1405 3.5e-152 casein kinase 1, alpha 1 [Saccoglossus kowalevskii]>gi|197734685|gb|ACH73238.1| casein kinase 1 protein catalytic subunit [Saccoglossus kowalevskii] 768410303 XM_011559102.1 355 0 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 P67827 1401 4.1e-153 Casein kinase I isoform alpha OS=Bos taurus GN=CSNK1A1 PE=1 SV=1 PF07714//PF00069//PF07850//PF05445//PF00180 Protein tyrosine kinase//Protein kinase domain//Renin receptor-like protein//Poxvirus serine/threonine protein kinase//Isocitrate/isopropylmalate dehydrogenase GO:0055114//GO:0006468//GO:0009069//GO:0016310//GO:0007165 oxidation-reduction process//protein phosphorylation//serine family amino acid metabolic process//phosphorylation//signal transduction GO:0004674//GO:0004672//GO:0016616//GO:0004872//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//receptor activity//ATP binding GO:0016021 integral component of membrane KOG1163 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39603 BF_2 3253.00 48.50 3093 91075936 XP_967560.1 3824 0.0e+00 PREDICTED: 26S proteasome non-ATPase regulatory subunit 2 [Tribolium castaneum]>gi|270014631|gb|EFA11079.1| hypothetical protein TcasGA2_TC004675 [Tribolium castaneum] 751232490 XM_011171561.1 352 0 PREDICTED: Solenopsis invicta 26S proteasome non-ATPase regulatory subunit 2 (LOC105202874), mRNA K03028 PSMD2, RPN1 26S proteasome regulatory subunit N1 http://www.genome.jp/dbget-bin/www_bget?ko:K03028 Q13200 3016 0.0e+00 26S proteasome non-ATPase regulatory subunit 2 OS=Homo sapiens GN=PSMD2 PE=1 SV=3 -- -- GO:0042176//GO:0050790 regulation of protein catabolic process//regulation of catalytic activity GO:0030234 enzyme regulator activity GO:0000502 proteasome complex KOG2005 26S proteasome regulatory complex, subunit RPN1/PSMD2 Cluster-8309.39604 BF_2 41.78 0.31 5966 91083631 XP_970382.1 3673 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 2.37549e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2881 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF00205//PF01752//PF02826//PF03188//PF02233//PF00005//PF07074//PF00107 Thiamine pyrophosphate enzyme, central domain//Collagenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//NAD(P) transhydrogenase beta subunit//ABC transporter//Translocon-associated protein, gamma subunit (TRAP-gamma)//Zinc-binding dehydrogenase GO:0006508//GO:0006769//GO:0015992//GO:0055114//GO:0046497//GO:0006613 proteolysis//nicotinamide metabolic process//proton transport//oxidation-reduction process//nicotinate nucleotide metabolic process//cotranslational protein targeting to membrane GO:0000287//GO:0030976//GO:0051287//GO:0050661//GO:0004252//GO:0016887//GO:0008270//GO:0008750//GO:0005524 magnesium ion binding//thiamine pyrophosphate binding//NAD binding//NADP binding//serine-type endopeptidase activity//ATPase activity//zinc ion binding//NAD(P)+ transhydrogenase (AB-specific) activity//ATP binding GO:0005576//GO:0005784//GO:0030176//GO:0016021 extracellular region//Sec61 translocon complex//integral component of endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.39605 BF_2 485.08 4.89 4433 642917718 XP_008191344.1 3290 0.0e+00 PREDICTED: ecotropic viral integration site 5 ortholog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VYY9 2192 7.9e-245 Ecotropic viral integration site 5 ortholog OS=Drosophila melanogaster GN=Evi5 PE=1 SV=3 PF10605//PF13013 3HB-oligomer hydrolase (3HBOH)//F-box-like domain GO:0019605 butyrate metabolic process GO:0005515//GO:0047989 protein binding//hydroxybutyrate-dimer hydrolase activity GO:0005615 extracellular space KOG1102 Rab6 GTPase activator GAPCenA and related TBC domain proteins Cluster-8309.39606 BF_2 117.84 6.24 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39607 BF_2 41.01 2.74 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39609 BF_2 260.32 4.77 2569 283046730 NP_001164311.1 1663 2.4e-182 tyramine/octopamine receptor [Tribolium castaneum]>gi|289191348|ref|NP_001164312.1| tyramine/octopamine receptor [Tribolium castaneum]>gi|642912074|ref|XP_008200790.1| PREDICTED: tyramine/octopamine receptor isoform X1 [Tribolium castaneum]>gi|270002886|gb|EEZ99333.1| hypothetical protein TcasGA2_TC004545 [Tribolium castaneum]>gi|485836728|tpg|DAA64498.1| TPA_inf: putative octopamine/tyramine receptor [Tribolium castaneum] 118782661 XM_312420.3 177 4.69094e-85 Anopheles gambiae str. PEST AGAP002519-PA (GPRTYR) mRNA, complete cds K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25188 1303 5.6e-142 Octopamine receptor OS=Heliothis virescens PE=2 SV=1 PF00001//PF08496//PF02480//PF01496 7 transmembrane receptor (rhodopsin family)//Peptidase family S49 N-terminal//Alphaherpesvirus glycoprotein E//V-type ATPase 116kDa subunit family GO:0007186//GO:0015992//GO:0007187//GO:0015991 G-protein coupled receptor signaling pathway//proton transport//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//ATP hydrolysis coupled proton transport GO:0015078//GO:0004252//GO:0004989//GO:0004930 hydrogen ion transmembrane transporter activity//serine-type endopeptidase activity//octopamine receptor activity//G-protein coupled receptor activity GO:0016020//GO:0033179//GO:0016021//GO:0005886 membrane//proton-transporting V-type ATPase, V0 domain//integral component of membrane//plasma membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.39610 BF_2 69.24 0.57 5378 642924425 XP_008194291.1 421 5.3e-38 PREDICTED: actin-binding Rho-activating protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BUZ1 131 9.3e-06 Actin-binding Rho-activating protein OS=Mus musculus GN=Abra PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3376 Uncharacterized conserved protein Cluster-8309.39612 BF_2 35.00 3.97 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39614 BF_2 549.30 0.83 27920 642928700 XP_008199744.1 29002 0.0e+00 PREDICTED: dystonin isoform X7 [Tribolium castaneum] 642928701 XM_008201523.1 1042 0 PREDICTED: Tribolium castaneum microtubule-actin cross-linking factor 1 (LOC662585), transcript variant X8, mRNA -- -- -- -- Q03001 4157 0.0e+00 Dystonin OS=Homo sapiens GN=DST PE=1 SV=4 PF07726//PF00270//PF00910//PF00608//PF00997//PF13465//PF14532//PF05496//PF00435//PF00628//PF06068//PF13520//PF06160//PF02367//PF00307//PF01695//PF07728//PF00681//PF00158//PF00004//PF06005 ATPase family associated with various cellular activities (AAA)//DEAD/DEAH box helicase//RNA helicase//Adenoviral fibre protein (repeat/shaft region)//Kappa casein//Zinc-finger double domain//Sigma-54 interaction domain//Holliday junction DNA helicase ruvB N-terminus//Spectrin repeat//PHD-finger//TIP49 C-terminus//Amino acid permease//Septation ring formation regulator, EzrA//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Calponin homology (CH) domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Plectin repeat//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Protein of unknown function (DUF904) GO:0006865//GO:0000921//GO:0003333//GO:0002949//GO:0006310//GO:0019062//GO:0007155//GO:0043093//GO:0000917//GO:0009405//GO:0006281//GO:0006355 amino acid transport//septin ring assembly//amino acid transmembrane transport//tRNA threonylcarbamoyladenosine modification//DNA recombination//virion attachment to host cell//cell adhesion//FtsZ-dependent cytokinesis//barrier septum assembly//pathogenesis//DNA repair//regulation of transcription, DNA-templated GO:0003678//GO:0003676//GO:0046872//GO:0005524//GO:0008134//GO:0016887//GO:0003723//GO:0005515//GO:0009378//GO:0003724//GO:0015171 DNA helicase activity//nucleic acid binding//metal ion binding//ATP binding//transcription factor binding//ATPase activity//RNA binding//protein binding//four-way junction helicase activity//RNA helicase activity//amino acid transmembrane transporter activity GO:0005667//GO:0005856//GO:0005657//GO:0016020//GO:0005576//GO:0016021//GO:0009379//GO:0005940//GO:0005737 transcription factor complex//cytoskeleton//replication fork//membrane//extracellular region//integral component of membrane//Holliday junction helicase complex//septin ring//cytoplasm KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.39615 BF_2 7340.59 11.14 27861 642928690 XP_008199739.1 28942 0.0e+00 PREDICTED: dystonin isoform X2 [Tribolium castaneum] 642928705 XM_008201526.1 1000 0 PREDICTED: Tribolium castaneum microtubule-actin cross-linking factor 1 (LOC662585), transcript variant X10, mRNA -- -- -- -- Q03001 4157 0.0e+00 Dystonin OS=Homo sapiens GN=DST PE=1 SV=4 PF00307//PF02367//PF06160//PF06005//PF00004//PF00158//PF07728//PF00681//PF01695//PF00608//PF13465//PF00997//PF00910//PF00270//PF07726//PF13520//PF00628//PF06068//PF05496//PF00435//PF14532 Calponin homology (CH) domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Septation ring formation regulator, EzrA//Protein of unknown function (DUF904)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//Plectin repeat//IstB-like ATP binding protein//Adenoviral fibre protein (repeat/shaft region)//Zinc-finger double domain//Kappa casein//RNA helicase//DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Amino acid permease//PHD-finger//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Spectrin repeat//Sigma-54 interaction domain GO:0000917//GO:0043093//GO:0007155//GO:0019062//GO:0006355//GO:0006281//GO:0009405//GO:0006310//GO:0002949//GO:0003333//GO:0000921//GO:0006865 barrier septum assembly//FtsZ-dependent cytokinesis//cell adhesion//virion attachment to host cell//regulation of transcription, DNA-templated//DNA repair//pathogenesis//DNA recombination//tRNA threonylcarbamoyladenosine modification//amino acid transmembrane transport//septin ring assembly//amino acid transport GO:0003724//GO:0009378//GO:0005515//GO:0003723//GO:0015171//GO:0046872//GO:0003676//GO:0003678//GO:0016887//GO:0008134//GO:0005524 RNA helicase activity//four-way junction helicase activity//protein binding//RNA binding//amino acid transmembrane transporter activity//metal ion binding//nucleic acid binding//DNA helicase activity//ATPase activity//transcription factor binding//ATP binding GO:0005576//GO:0016020//GO:0005657//GO:0005856//GO:0005737//GO:0005940//GO:0009379//GO:0016021//GO:0005667 extracellular region//membrane//replication fork//cytoskeleton//cytoplasm//septin ring//Holliday junction helicase complex//integral component of membrane//transcription factor complex KOG0516 Dystonin, GAS (Growth-arrest-specific protein), and related proteins Cluster-8309.39616 BF_2 669.06 13.92 2298 546684894 ERL94476.1 1195 4.0e-128 hypothetical protein D910_11753 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H3P7 604 5.6e-61 Golgi resident protein GCP60 OS=Homo sapiens GN=ACBD3 PE=1 SV=4 PF00887//PF13897 Acyl CoA binding protein//Golgi-dynamics membrane-trafficking GO:0006810 transport GO:0000062 fatty-acyl-CoA binding GO:0016021 integral component of membrane KOG3878 Protein involved in maintenance of Golgi structure and ER-Golgi transport Cluster-8309.39617 BF_2 249.29 1.46 7446 642930792 XP_008196093.1 1047 1.9e-110 PREDICTED: ski oncogene [Tribolium castaneum] 759170310 XM_011377342.1 126 3.07386e-56 PREDICTED: Pteropus vampyrus SKI proto-oncogene (SKI), partial mRNA K18499 SKIL Ski-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K18499 P17863 674 1.4e-68 Transforming protein Ski OS=Avian erythroblastosis virus (strain Sloan-Kettering) GN=V-SKI PE=1 SV=1 PF08782//PF04501//PF11365 c-SKI Smad4 binding domain//Baculovirus major capsid protein VP39//Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy GO:0046332//GO:0005198 SMAD binding//structural molecule activity GO:0005615//GO:0019028 extracellular space//viral capsid -- -- Cluster-8309.39618 BF_2 240.56 1.29 8093 270011987 EFA08435.1 1048 1.6e-110 hypothetical protein TcasGA2_TC006082 [Tribolium castaneum] 759170310 XM_011377342.1 126 3.34229e-56 PREDICTED: Pteropus vampyrus SKI proto-oncogene (SKI), partial mRNA K18499 SKIL Ski-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K18499 P17863 674 1.5e-68 Transforming protein Ski OS=Avian erythroblastosis virus (strain Sloan-Kettering) GN=V-SKI PE=1 SV=1 PF08782//PF04501//PF11365 c-SKI Smad4 binding domain//Baculovirus major capsid protein VP39//Protein of unknown function (DUF3166) GO:0010506 regulation of autophagy GO:0046332//GO:0005198 SMAD binding//structural molecule activity GO:0019028//GO:0005615 viral capsid//extracellular space -- -- Cluster-8309.39619 BF_2 312.72 1.64 8255 56756172 CAH65679.2 2465 7.9e-275 acetylcholinesterase precursor [Nilaparvata lugens] 642913509 XM_008202822.1 782 0 PREDICTED: Tribolium castaneum acetylcholinesterase 2 (LOC659368), mRNA K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 Q27677 3038 0.0e+00 Acetylcholinesterase OS=Leptinotarsa decemlineata PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG4389 Acetylcholinesterase/Butyrylcholinesterase Cluster-8309.3962 BF_2 2.00 0.40 494 642912701 XP_970424.2 250 3.3e-19 PREDICTED: histone-lysine N-methyltransferase SMYD3 [Tribolium castaneum] -- -- -- -- -- K11426 SMYD SET and MYND domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11426 Q9H7B4 124 5.5e-06 Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens GN=SMYD3 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.39620 BF_2 2299.14 37.44 2856 332376452 AEE63366.1 839 9.6e-87 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08360 CYB561 cytochrome b-561 http://www.genome.jp/dbget-bin/www_bget?ko:K08360 P34465 448 8.6e-43 Putative cytochrome b561 OS=Caenorhabditis elegans GN=F55H2.5 PE=3 SV=1 PF01292//PF03188//PF03124 Prokaryotic cytochrome b561//Eukaryotic cytochrome b561//EXS family GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.39621 BF_2 23.82 0.39 2839 91080431 XP_968599.1 454 4.2e-42 PREDICTED: uncharacterized protein LOC657017 [Tribolium castaneum]>gi|270005753|gb|EFA02201.1| hypothetical protein TcasGA2_TC007858 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39624 BF_2 1018.52 17.41 2734 642925558 XP_008194598.1 1219 7.9e-131 PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925560|ref|XP_008194599.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925562|ref|XP_008194600.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|270008677|gb|EFA05125.1| hypothetical protein TcasGA2_TC015240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6Q4G4 345 7.2e-31 Angiotensin-converting enzyme OS=Theromyzon tessulatum GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.39625 BF_2 233.50 2.12 4886 270008325 EFA04773.1 2064 1.5e-228 hypothetical protein TcasGA2_TC030724 [Tribolium castaneum] 170040110 XM_001847803.1 272 1.38947e-137 Culex quinquefasciatus elongation factor G 1, mitochondrial, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 B0WGM1 1954 3.4e-217 Elongation factor G, mitochondrial OS=Culex quinquefasciatus GN=CPIJ005834 PE=3 SV=1 PF03764//PF03144//PF05485 Elongation factor G, domain IV//Elongation factor Tu domain 2//THAP domain -- -- GO:0005525//GO:0003676 GTP binding//nucleic acid binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.39626 BF_2 17.00 1.57 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39627 BF_2 1004.37 6.65 6609 549438543 AGX25160.1 1445 1.2e-156 cathepsin B precursor [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9GZM7 895 2.9e-94 Tubulointerstitial nephritis antigen-like OS=Homo sapiens GN=TINAGL1 PE=1 SV=1 PF00112//PF03051//PF04218 Papain family cysteine protease//Peptidase C1-like family//CENP-B N-terminal DNA-binding domain GO:0006508 proteolysis GO:0003677//GO:0008234//GO:0004197 DNA binding//cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.39628 BF_2 379.82 6.04 2917 91090210 XP_967762.1 1212 5.5e-130 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P09875 423 7.0e-40 UDP-glucuronosyltransferase 2B1 OS=Rattus norvegicus GN=Ugt2b1 PE=2 SV=1 PF10660//PF04101//PF00201//PF01708 Iron-containing outer mitochondrial membrane protein N-terminus//Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Geminivirus putative movement protein GO:0046740//GO:0008152 transport of virus in host, cell to cell//metabolic process GO:0016757//GO:0051537//GO:0016758 transferase activity, transferring glycosyl groups//2 iron, 2 sulfur cluster binding//transferase activity, transferring hexosyl groups GO:0016021//GO:0043231 integral component of membrane//intracellular membrane-bounded organelle -- -- Cluster-8309.39630 BF_2 2990.37 19.68 6642 91076984 XP_975463.1 1520 2.4e-165 PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913260|ref|XP_008201461.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|642913262|ref|XP_008201462.1| PREDICTED: ras GTPase-activating protein-binding protein 2 [Tribolium castaneum]>gi|270001993|gb|EEZ98440.1| hypothetical protein TcasGA2_TC000929 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97379 482 2.3e-46 Ras GTPase-activating protein-binding protein 2 OS=Mus musculus GN=G3bp2 PE=1 SV=2 PF15886//PF16367//PF00076//PF02136 Carbohydrate binding domain (family 32)//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nuclear transport factor 2 (NTF2) domain GO:0006810 transport GO:0003676//GO:0030246 nucleic acid binding//carbohydrate binding GO:0005622 intracellular KOG0116 RasGAP SH3 binding protein rasputin, contains NTF2 and RRM domains Cluster-8309.39631 BF_2 353.52 6.73 2486 270007205 EFA03653.1 2111 2.7e-234 hypothetical protein TcasGA2_TC013747 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 P83740 1484 5.5e-163 Putative sodium-dependent multivitamin transporter OS=Drosophila melanogaster GN=CG32669 PE=2 SV=1 PF00474//PF01781//PF10716 Sodium:solute symporter family//Ribosomal L38e protein family//NADH dehydrogenase transmembrane subunit GO:0055085//GO:0006412//GO:0006810//GO:0006118//GO:0055114//GO:0042254 transmembrane transport//translation//transport//obsolete electron transport//oxidation-reduction process//ribosome biogenesis GO:0005215//GO:0003735//GO:0016655 transporter activity//structural constituent of ribosome//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005840//GO:0005622//GO:0016020 ribosome//intracellular//membrane -- -- Cluster-8309.39633 BF_2 217.92 1.05 8940 642911235 XP_008199694.1 6755 0.0e+00 PREDICTED: laminin subunit beta-1 [Tribolium castaneum] 198455549 XM_001360008.2 44 1.41582e-10 Drosophila pseudoobscura pseudoobscura GA20347 (Dpse\GA20347), partial mRNA K05636 LAMB1 laminin, beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05636 P11046 4487 0.0e+00 Laminin subunit beta-1 OS=Drosophila melanogaster GN=LanB1 PE=1 SV=4 PF05384//PF01133//PF00874//PF10440//PF00089//PF05007//PF03554 Sensor protein DegS//Enhancer of rudimentary//PRD domain//Ubiquitin-binding WIYLD domain//Trypsin//Mannosyltransferase (PIG-M)//UL73 viral envelope glycoprotein GO:0006554//GO:0007049//GO:0006479//GO:0006508//GO:0006506//GO:0006355//GO:0045747//GO:0007165//GO:0006221 lysine catabolic process//cell cycle//protein methylation//proteolysis//GPI anchor biosynthetic process//regulation of transcription, DNA-templated//positive regulation of Notch signaling pathway//signal transduction//pyrimidine nucleotide biosynthetic process GO:0004252//GO:0016301//GO:0018024//GO:0016758 serine-type endopeptidase activity//kinase activity//histone-lysine N-methyltransferase activity//transferase activity, transferring hexosyl groups GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG0994 Extracellular matrix glycoprotein Laminin subunit beta Cluster-8309.39635 BF_2 1115.36 4.22 11353 642933491 XP_008197440.1 3273 0.0e+00 PREDICTED: spermatogenesis-associated protein 20 [Tribolium castaneum]>gi|270011341|gb|EFA07789.1| hypothetical protein TcasGA2_TC005347 [Tribolium castaneum] 642933492 XM_962542.2 211 2.63256e-103 PREDICTED: Tribolium castaneum 40S ribosomal protein S9 (LOC661823), mRNA -- -- -- -- Q8TB22 1887 4.7e-209 Spermatogenesis-associated protein 20 OS=Homo sapiens GN=SPATA20 PE=2 SV=3 PF00163//PF01479 Ribosomal protein S4/S9 N-terminal domain//S4 domain GO:0008152 metabolic process GO:0003824//GO:0019843//GO:0003723 catalytic activity//rRNA binding//RNA binding GO:0005622 intracellular KOG3301 Ribosomal protein S4 Cluster-8309.39636 BF_2 796.59 2.66 12797 817208819 XP_012280436.1 6887 0.0e+00 PREDICTED: uncharacterized protein LOC105699757 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9U943 866 1.3e-90 Apolipophorins OS=Locusta migratoria PE=1 SV=2 PF09172//PF01347//PF06448 Domain of unknown function (DUF1943)//Lipoprotein amino terminal region//Domain of Unknown Function (DUF1081) GO:0006869 lipid transport GO:0005319 lipid transporter activity -- -- KOG4338 Predicted lipoprotein Cluster-8309.39638 BF_2 274.06 1.48 8010 91083409 XP_968752.1 826 8.6e-85 PREDICTED: sodium/potassium/calcium exchanger 4 [Tribolium castaneum]>gi|270006894|gb|EFA03342.1| hypothetical protein TcasGA2_TC013319 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q8NFF2 545 1.4e-53 Sodium/potassium/calcium exchanger 4 OS=Homo sapiens GN=SLC24A4 PE=1 SV=2 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.39639 BF_2 32.05 0.36 3977 270007709 EFA04157.1 2983 0.0e+00 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1117 3.2e-120 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF02705//PF13304//PF00005//PF03193 ABC transporter transmembrane region//K+ potassium transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0006810//GO:0006813//GO:0071805 transmembrane transport//transport//potassium ion transport//potassium ion transmembrane transport GO:0016887//GO:0005525//GO:0042626//GO:0015079//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//potassium ion transmembrane transporter activity//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.39641 BF_2 58.79 0.99 2772 642933768 XP_008197204.1 2252 1.3e-250 PREDICTED: WD repeat-containing protein mio-B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q802U2 1067 1.4e-114 WD repeat-containing protein mio OS=Danio rerio GN=mios PE=2 SV=1 PF12678//PF00400//PF13639//PF15750 RING-H2 zinc finger//WD domain, G-beta repeat//Ring finger domain//Ubiquitin-binding zinc-finger -- -- GO:0005515//GO:0043130//GO:0008270 protein binding//ubiquitin binding//zinc ion binding -- -- KOG1008 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.39642 BF_2 1044.54 29.65 1761 642912068 XP_008200785.1 1450 8.3e-158 PREDICTED: peroxidase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 590 1.8e-59 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.39644 BF_2 4336.51 67.27 2984 546673984 ERL85488.1 866 7.4e-90 hypothetical protein D910_02907 [Dendroctonus ponderosae] 506968668 KC740854.1 184 7.00754e-89 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 776 8.3e-81 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.39645 BF_2 1577.87 19.62 3652 91086631 XP_966390.1 1735 1.6e-190 PREDICTED: abhydrolase domain-containing protein 2 [Tribolium castaneum]>gi|270010379|gb|EFA06827.1| hypothetical protein TcasGA2_TC009769 [Tribolium castaneum] -- -- -- -- -- K13697 ABHD2 abhydrolase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13697 Q24093 1475 9.0e-162 Abhydrolase domain-containing protein 2 OS=Drosophila melanogaster GN=Hydr2 PE=2 SV=2 PF01764//PF00326//PF02230//PF01738//PF01083 Lipase (class 3)//Prolyl oligopeptidase family//Phospholipase/Carboxylesterase//Dienelactone hydrolase family//Cutinase GO:0008152//GO:0006508//GO:0006629 metabolic process//proteolysis//lipid metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG1838 Alpha/beta hydrolase Cluster-8309.39646 BF_2 322.69 1.53 9095 642914109 XP_008201547.1 3881 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12923 427 7.5e-40 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF00595//PF02873//PF13180//PF08997 PDZ domain (Also known as DHR or GLGF)//UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain//PDZ domain//Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0055114//GO:0015992//GO:0006118//GO:0006119//GO:0006040 oxidation-reduction process//proton transport//obsolete electron transport//oxidative phosphorylation//amino sugar metabolic process GO:0009055//GO:0008762//GO:0005515//GO:0008121 electron carrier activity//UDP-N-acetylmuramate dehydrogenase activity//protein binding//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.39648 BF_2 897.47 24.07 1847 91082161 XP_970591.1 1226 8.2e-132 PREDICTED: reticulocalbin-2 [Tribolium castaneum]>gi|270007433|gb|EFA03881.1| hypothetical protein TcasGA2_TC014005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X186 510 3.6e-50 Calumenin-A OS=Salmo salar GN=calua PE=2 SV=1 PF13405//PF10591//PF00036//PF13833//PF13499//PF13202//PF12763 EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG4223 Reticulocalbin, calumenin, DNA supercoiling factor, and related Ca2+-binding proteins of the CREC family (EF-Hand protein superfamily) Cluster-8309.39650 BF_2 66.61 0.80 3766 270014029 EFA10477.1 699 2.2e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.25743e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- Q5R6A9 173 8.8e-11 TOX high mobility group box family member 4 OS=Pongo abelii GN=TOX4 PE=2 SV=2 PF11770//PF03460 GRB2-binding adapter (GAPT)//Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.39651 BF_2 19.49 0.41 2299 91076006 XP_966406.1 2269 1.2e-252 PREDICTED: very long-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270014595|gb|EFA11043.1| hypothetical protein TcasGA2_TC004634 [Tribolium castaneum] 676425561 XM_009046107.1 184 5.38333e-89 Lottia gigantea hypothetical protein partial mRNA K09479 ACADVL very long chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09479 Q8HXY7 1652 1.7e-182 Very long-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Macaca fascicularis GN=ACADVL PE=2 SV=1 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.39652 BF_2 671.91 5.23 5659 91080669 XP_975087.1 970 1.2e-101 PREDICTED: vesicle-trafficking protein SEC22b-B [Tribolium castaneum]>gi|270005842|gb|EFA02290.1| hypothetical protein TcasGA2_TC007954 [Tribolium castaneum] 746866518 XM_011066023.1 149 3.82295e-69 PREDICTED: Acromyrmex echinatior vesicle-trafficking protein SEC22b (LOC105152004), transcript variant X3, mRNA K08517 SEC22 vesicle transport protein SEC22 http://www.genome.jp/dbget-bin/www_bget?ko:K08517 Q7SXP0 719 6.4e-74 Vesicle-trafficking protein SEC22b-B OS=Danio rerio GN=sec22bb PE=2 SV=1 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0862 Synaptobrevin/VAMP-like protein SEC22 Cluster-8309.39654 BF_2 197.92 1.44 6019 642936708 XP_008198548.1 756 8.5e-77 PREDICTED: tRNA pseudouridine synthase-like 1 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 420 3.2e-39 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF01416//PF02868//PF00782//PF01529//PF00102//PF08777//PF04179 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA pseudouridine synthase//Thermolysin metallopeptidase, alpha-helical domain//Dual specificity phosphatase, catalytic domain//DHHC palmitoyltransferase//Protein-tyrosine phosphatase//RNA binding motif//Initiator tRNA phosphoribosyl transferase GO:0006470//GO:0006570//GO:0019988//GO:0001522//GO:0009451 protein dephosphorylation//tyrosine metabolic process//charged-tRNA amino acid modification//pseudouridine synthesis//RNA modification GO:0008138//GO:0004725//GO:0043399//GO:0003723//GO:0004222//GO:0003676//GO:0009982//GO:0008270 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//tRNA A64-2'-O-ribosylphosphate transferase activity//RNA binding//metalloendopeptidase activity//nucleic acid binding//pseudouridine synthase activity//zinc ion binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.39657 BF_2 1228.50 7.50 7140 91089729 XP_975072.1 3304 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1914 2.2e-212 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF09726//PF10473//PF05024//PF07926//PF13326//PF00769//PF08702//PF15191//PF15898//PF04111//PF00709//PF00170//PF03790//PF00654//PF13851 Transmembrane protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//N-acetylglucosaminyl transferase component (Gpi1)//TPR/MLP1/MLP2-like protein//Photosystem II Pbs27//Ezrin/radixin/moesin family//Fibrinogen alpha/beta chain family//Synaptonemal complex central element protein 3//cGMP-dependent protein kinase interacting domain//Autophagy protein Apg6//Adenylosuccinate synthetase//bZIP transcription factor//KNOX1 domain//Voltage gated chloride channel//Growth-arrest specific micro-tubule binding GO:0006164//GO:0055085//GO:0006606//GO:0006531//GO:0048870//GO:0010207//GO:0030168//GO:0006914//GO:0051258//GO:0007165//GO:0007283//GO:0006355//GO:0007131//GO:0006144//GO:0006821//GO:0007130//GO:0006522//GO:0006506 purine nucleotide biosynthetic process//transmembrane transport//protein import into nucleus//aspartate metabolic process//cell motility//photosystem II assembly//platelet activation//autophagy//protein polymerization//signal transduction//spermatogenesis//regulation of transcription, DNA-templated//reciprocal meiotic recombination//purine nucleobase metabolic process//chloride transport//synaptonemal complex assembly//alanine metabolic process//GPI anchor biosynthetic process GO:0045502//GO:0008134//GO:0003700//GO:0005102//GO:0008092//GO:0004019//GO:0030674//GO:0043565//GO:0019901//GO:0005247//GO:0017176//GO:0003677//GO:0005525//GO:0042803 dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//receptor binding//cytoskeletal protein binding//adenylosuccinate synthase activity//protein binding, bridging//sequence-specific DNA binding//protein kinase binding//voltage-gated chloride channel activity//phosphatidylinositol N-acetylglucosaminyltransferase activity//DNA binding//GTP binding//protein homodimerization activity GO:0019898//GO:0005577//GO:0005667//GO:0030286//GO:0016021//GO:0031514//GO:0005737//GO:0005634//GO:0016020 extrinsic component of membrane//fibrinogen complex//transcription factor complex//dynein complex//integral component of membrane//motile cilium//cytoplasm//nucleus//membrane KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.39658 BF_2 18.89 0.55 1734 546683511 ERL93317.1 311 9.7e-26 hypothetical protein D910_10611 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39660 BF_2 117.81 0.74 6942 642935550 XP_008198055.1 345 4.5e-29 PREDICTED: toxin S6C6 [Tribolium castaneum] -- -- -- -- -- K04008 CD59 CD59 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04008 -- -- -- -- PF00087//PF01051 Snake toxin//Initiator Replication protein GO:0006260//GO:0009405//GO:0006270 DNA replication//pathogenesis//DNA replication initiation GO:0003887 DNA-directed DNA polymerase activity GO:0005576//GO:0005727//GO:0042575 extracellular region//extrachromosomal circular DNA//DNA polymerase complex -- -- Cluster-8309.39661 BF_2 103.42 0.50 8993 642916202 XP_008190929.1 540 1.4e-51 PREDICTED: uncharacterized protein LOC103312333 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q59SG9 137 3.1e-06 Probable GPI-anchored adhesin-like protein PGA55 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PGA55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39662 BF_2 255.07 3.23 3590 189239253 XP_001807041.1 350 6.1e-30 PREDICTED: uncharacterized protein LOC100141764 [Tribolium castaneum]>gi|270010382|gb|EFA06830.1| hypothetical protein TcasGA2_TC009773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08299//PF05028//PF15178 Bacterial dnaA protein helix-turn-helix//Poly (ADP-ribose) glycohydrolase (PARG)//Mitochondrial import receptor subunit TOM5 homolog GO:0006275//GO:0005975//GO:0006270 regulation of DNA replication//carbohydrate metabolic process//DNA replication initiation GO:0043565//GO:0005524//GO:0004649 sequence-specific DNA binding//ATP binding//poly(ADP-ribose) glycohydrolase activity GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.39663 BF_2 1737.00 68.24 1352 755989638 XP_011312250.1 821 5.5e-85 PREDICTED: eukaryotic translation initiation factor 2 subunit 2 [Fopius arisanus] 815925611 XM_003493657.2 170 1.89809e-81 PREDICTED: Bombus impatiens eukaryotic translation initiation factor 2 subunit 2 (LOC100741877), mRNA K03238 EIF2S2 translation initiation factor 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03238 Q99L45 735 2.1e-76 Eukaryotic translation initiation factor 2 subunit 2 OS=Mus musculus GN=Eif2s2 PE=1 SV=1 PF01873 Domain found in IF2B/IF5 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG2768 Translation initiation factor 2, beta subunit (eIF-2beta) Cluster-8309.39664 BF_2 151.24 2.07 3342 270000870 EEZ97317.1 1789 7.8e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.34514e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.5e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.39665 BF_2 676.84 10.49 2987 91090214 XP_967924.1 1528 1.3e-166 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 652 2.0e-66 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.39666 BF_2 1939.23 26.36 3365 91092160 XP_967690.1 893 6.2e-93 PREDICTED: RNA-binding protein 24-B [Tribolium castaneum]>gi|270014448|gb|EFA10896.1| hypothetical protein TcasGA2_TC001720 [Tribolium castaneum] 645005484 XM_001606127.3 101 1.09093e-42 PREDICTED: Nasonia vitripennis RNA-binding protein 24-A-like (LOC100122565), transcript variant X3, mRNA -- -- -- -- Q6GQD3 445 2.3e-42 RNA-binding protein 24-A OS=Xenopus laevis GN=rbm24-a PE=2 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0149 Predicted RNA-binding protein SEB4 (RRM superfamily) Cluster-8309.39672 BF_2 1558.00 19.11 3698 642937495 XP_008198863.1 967 1.8e-101 PREDICTED: protein tramtrack, beta isoform-like isoform X24 [Tribolium castaneum] 462328819 APGK01040556.1 149 2.48971e-69 Dendroctonus ponderosae Seq01040566, whole genome shotgun sequence -- -- -- -- Q86B87 360 1.8e-32 Modifier of mdg4 OS=Drosophila melanogaster GN=mod(mdg4) PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.39673 BF_2 47.94 1.13 2061 642937449 XP_008198840.1 563 7.0e-55 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39676 BF_2 1791.39 23.83 3432 642929344 XP_008195795.1 1865 1.2e-205 PREDICTED: AMP deaminase 2 isoform X6 [Tribolium castaneum]>gi|270009636|gb|EFA06084.1| hypothetical protein TcasGA2_TC008921 [Tribolium castaneum] 194769475 XM_001966794.1 279 1.24967e-141 Drosophila ananassae GF19072 (Dana\GF19072), mRNA K01490 AMPD AMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01490 Q01433 1107 4.0e-119 AMP deaminase 2 OS=Homo sapiens GN=AMPD2 PE=1 SV=2 PF00465//PF00962 Iron-containing alcohol dehydrogenase//Adenosine/AMP deaminase GO:0006144//GO:0006188//GO:0009168//GO:0055114//GO:0006807 purine nucleobase metabolic process//IMP biosynthetic process//purine ribonucleoside monophosphate biosynthetic process//oxidation-reduction process//nitrogen compound metabolic process GO:0016491//GO:0019239//GO:0003876//GO:0046872 oxidoreductase activity//deaminase activity//AMP deaminase activity//metal ion binding -- -- KOG1096 Adenosine monophosphate deaminase Cluster-8309.39678 BF_2 1704.80 20.52 3763 642930759 XP_008196081.1 256 5.1e-19 PREDICTED: sialin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39679 BF_2 3605.24 15.32 10130 270003787 EFA00235.1 2422 9.4e-270 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 462304009 APGK01049651.1 110 3.28319e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 871 2.7e-91 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF13895//PF00041//PF16656//PF08176//PF01637//PF03193//PF02899//PF00005//PF03931//PF01926//PF13304//PF01061//PF07714//PF00069//PF00621 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Small acid-soluble spore protein K family//Archaeal ATPase//Protein of unknown function, DUF258//Phage integrase, N-terminal SAM-like domain//ABC transporter//Skp1 family, tetramerisation domain//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter//Protein tyrosine kinase//Protein kinase domain//RhoGEF domain GO:0035023//GO:0019497//GO:0006468//GO:0030436//GO:0006771//GO:0043087//GO:0006511//GO:0015074 regulation of Rho protein signal transduction//hexachlorocyclohexane metabolic process//protein phosphorylation//asexual sporulation//riboflavin metabolic process//regulation of GTPase activity//ubiquitin-dependent protein catabolic process//DNA integration GO:0005524//GO:0003924//GO:0016887//GO:0003993//GO:0003677//GO:0005515//GO:0005525//GO:0046872//GO:0004672//GO:0005089 ATP binding//GTPase activity//ATPase activity//acid phosphatase activity//DNA binding//protein binding//GTP binding//metal ion binding//protein kinase activity//Rho guanyl-nucleotide exchange factor activity GO:0042601//GO:0016020 endospore-forming forespore//membrane -- -- Cluster-8309.39680 BF_2 31.42 2.02 939 478250090 ENN70596.1 1091 1.9e-116 hypothetical protein YQE_12771, partial [Dendroctonus ponderosae] -- -- -- -- -- K05701 TJP1, ZO1 tight junction protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05701 O97758 168 8.3e-11 Tight junction protein ZO-1 OS=Canis familiaris GN=TJP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3580 Tight junction proteins Cluster-8309.39681 BF_2 115.16 1.24 4160 642915162 XP_008190500.1 1849 1.1e-203 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02562 152 2.6e-08 Myosin heavy chain, skeletal muscle (Fragments) OS=Oryctolagus cuniculus PE=1 SV=2 PF02135//PF02183 TAZ zinc finger//Homeobox associated leucine zipper GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0004402//GO:0003700//GO:0003712//GO:0043565//GO:0008270 histone acetyltransferase activity//transcription factor activity, sequence-specific DNA binding//transcription cofactor activity//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634//GO:0000123 transcription factor complex//nucleus//histone acetyltransferase complex -- -- Cluster-8309.39682 BF_2 812.78 7.96 4559 270013465 EFA09913.1 1341 9.4e-145 hypothetical protein TcasGA2_TC012064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 568 1.7e-56 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.39683 BF_2 10.83 0.44 1318 91094851 XP_972051.1 1070 7.2e-114 PREDICTED: 6-phosphogluconate dehydrogenase, decarboxylating [Tribolium castaneum]>gi|270006577|gb|EFA03025.1| hypothetical protein TcasGA2_TC010448 [Tribolium castaneum] 440206336 JQ787165.1 77 9.23365e-30 Metanomeuta fulvicrinis voucher Cvag phosphogluconate dehydrogenase mRNA, partial cds K00033 PGD, gnd, gntZ 6-phosphogluconate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00033 P41570 884 1.1e-93 6-phosphogluconate dehydrogenase, decarboxylating OS=Ceratitis capitata GN=Pgd PE=2 SV=1 PF00393 6-phosphogluconate dehydrogenase, C-terminal domain GO:0019521//GO:0006098//GO:0055114 D-gluconate metabolic process//pentose-phosphate shunt//oxidation-reduction process GO:0050661//GO:0004616 NADP binding//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG2653 6-phosphogluconate dehydrogenase Cluster-8309.39684 BF_2 238.46 2.70 3987 646717218 KDR20164.1 788 1.1e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.26758e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.5e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.39686 BF_2 88.69 1.79 2360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178//PF03286 AT hook motif//Pox virus Ag35 surface protein -- -- GO:0003677 DNA binding GO:0019031 viral envelope -- -- Cluster-8309.39687 BF_2 342.95 6.53 2483 642930832 XP_008196105.1 690 1.6e-69 PREDICTED: apoptosis-inducing factor 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96NN9 406 5.5e-38 Apoptosis-inducing factor 3 OS=Homo sapiens GN=AIFM3 PE=1 SV=1 PF00348//PF07992 Polyprenyl synthetase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0008299 oxidation-reduction process//isoprenoid biosynthetic process GO:0016491 oxidoreductase activity -- -- KOG1336 Monodehydroascorbate/ferredoxin reductase Cluster-8309.39689 BF_2 56.00 3.21 1017 403311095 AFR34054.1 1206 9.4e-130 NADH dehydrogenase subunit 5 (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 1014 0 Scylla paramamosain mitochondrion, complete genome K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 P07706 646 3.4e-66 NADH-ubiquinone oxidoreductase chain 5 OS=Drosophila yakuba GN=mt:ND5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-8309.3969 BF_2 30.00 0.46 3038 642935265 XP_008197939.1 481 3.3e-45 PREDICTED: LOW QUALITY PROTEIN: rho GTPase-activating protein 100F [Tribolium castaneum] 462323311 APGK01042524.1 75 2.79393e-28 Dendroctonus ponderosae Seq01042534, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39690 BF_2 665.48 5.72 5150 642939347 XP_970218.2 2431 4.3e-271 PREDICTED: lipase maturation factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKZ9 1010 1.1e-107 Lipase maturation factor 2 OS=Gallus gallus GN=LMF2 PE=2 SV=2 PF05175//PF03602//PF01741//PF10237 Methyltransferase small domain//Conserved hypothetical protein 95//Large-conductance mechanosensitive channel, MscL//Probable N6-adenine methyltransferase GO:0006810//GO:0031167//GO:0006811 transport//rRNA methylation//ion transport GO:0005216//GO:0008168 ion channel activity//methyltransferase activity GO:0016021 integral component of membrane KOG3350 Uncharacterized conserved protein Cluster-8309.39692 BF_2 44.92 0.57 3581 642913885 XP_008201201.1 1316 5.9e-142 PREDICTED: forkhead box protein O isoform X2 [Tribolium castaneum] 642913884 XM_008202979.1 416 0 PREDICTED: Tribolium castaneum forkhead box protein O (LOC664090), transcript variant X2, mRNA K09408 FOXO3 forkhead box protein O3 http://www.genome.jp/dbget-bin/www_bget?ko:K09408 B3LYS5 667 4.3e-68 Forkhead box protein O OS=Drosophila ananassae GN=foxo PE=3 SV=2 PF01342//PF00250 SAND domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677//GO:0003700 sequence-specific DNA binding//DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.39693 BF_2 1977.29 26.25 3438 91076824 XP_967870.1 1208 1.9e-129 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 729 2.7e-75 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- KOG1212 Amidases Cluster-8309.39695 BF_2 370.06 4.18 3991 642922190 XP_008193053.1 1274 4.8e-137 PREDICTED: patronin isoform X1 [Tribolium castaneum] -- -- -- -- -- K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 285 9.6e-24 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39696 BF_2 2123.68 17.84 5266 189235271 XP_973061.2 1362 4.0e-147 PREDICTED: MKL/myocardin-like protein 2 isoform X1 [Tribolium castaneum] 642916149 XM_967968.3 439 0 PREDICTED: Tribolium castaneum MKL/myocardin-like protein 2 (LOC661834), transcript variant X1, mRNA -- -- -- -- Q8K4J6 314 5.5e-27 MKL/myocardin-like protein 1 OS=Mus musculus GN=Mkl1 PE=1 SV=2 PF11744 Aluminium activated malate transporter GO:0015743 malate transport -- -- -- -- -- -- Cluster-8309.3970 BF_2 2.00 0.37 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39700 BF_2 836.08 3.36 10688 270014310 EFA10758.1 3865 0.0e+00 starry night [Tribolium castaneum] 332376259 BT128312.1 203 6.93826e-99 Dendroctonus ponderosae clone DPO105_N17 unknown mRNA K04600 CELSR1 cadherin EGF LAG seven-pass G-type receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04600 Q9V5N8 1132 1.6e-121 Protocadherin-like wing polarity protein stan OS=Drosophila melanogaster GN=stan PE=1 SV=4 PF00002//PF07732//PF02421//PF03348//PF00025//PF01926//PF08477//PF00071//PF04670//PF01825//PF02793//PF00837//PF03193 7 transmembrane receptor (Secretin family)//Multicopper oxidase//Ferrous iron transport protein B//Serine incorporator (Serinc)//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ras family//Gtr1/RagA G protein conserved region//GPCR proteolysis site, GPS, motif//Hormone receptor domain//Iodothyronine deiodinase//Protein of unknown function, DUF258 GO:0015684//GO:0007264//GO:0055114//GO:0007186 ferrous iron transport//small GTPase mediated signal transduction//oxidation-reduction process//G-protein coupled receptor signaling pathway GO:0005525//GO:0004800//GO:0003924//GO:0004930//GO:0005507//GO:0015093 GTP binding//thyroxine 5'-deiodinase activity//GTPase activity//G-protein coupled receptor activity//copper ion binding//ferrous iron transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.39702 BF_2 51.55 1.11 2231 642937160 XP_969386.2 560 1.7e-54 PREDICTED: prolyl 4-hydroxylase subunit alpha-1 [Tribolium castaneum] -- -- -- -- -- K00472 E1.14.11.2 prolyl 4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00472 Q1RMU3 379 6.7e-35 Prolyl 4-hydroxylase subunit alpha-1 OS=Bos taurus GN=P4HA1 PE=1 SV=1 PF08476//PF13640//PF03171 Viral D10 N-terminal//2OG-Fe(II) oxygenase superfamily//2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016791//GO:0016491 phosphatase activity//oxidoreductase activity -- -- KOG1591 Prolyl 4-hydroxylase alpha subunit Cluster-8309.39703 BF_2 2419.70 14.73 7160 270001906 EEZ98353.1 273 1.0e-20 hypothetical protein TcasGA2_TC000810 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39706 BF_2 34.83 0.44 3577 91083493 XP_976358.1 1712 7.1e-188 PREDICTED: uncharacterized protein LOC660773 [Tribolium castaneum]>gi|642928430|ref|XP_008193781.1| PREDICTED: uncharacterized protein LOC660773 [Tribolium castaneum]>gi|270010837|gb|EFA07285.1| hypothetical protein TcasGA2_TC014520 [Tribolium castaneum] -- -- -- -- -- K00586 DPH5 diphthine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00586 Q9H2P9 611 1.4e-61 Diphthine methyl ester synthase OS=Homo sapiens GN=DPH5 PE=1 SV=2 PF06743//PF00590 FAST kinase-like protein, subdomain 1//Tetrapyrrole (Corrin/Porphyrin) Methylases GO:0008152 metabolic process GO:0004672//GO:0008168 protein kinase activity//methyltransferase activity -- -- KOG3123 Diphthine synthase Cluster-8309.39707 BF_2 407.42 18.63 1202 557767939 XP_005183655.1 515 1.5e-49 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Musca domestica] 195569934 XM_002102928.1 182 3.58954e-88 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P47815 390 1.9e-36 Eukaryotic translation initiation factor 1A OS=Triticum aestivum PE=1 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.39708 BF_2 18.00 0.40 2176 91079674 XP_967161.1 318 1.9e-26 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Tribolium castaneum]>gi|270004484|gb|EFA00932.1| hypothetical protein TcasGA2_TC003838 [Tribolium castaneum] 195569934 XM_002102928.1 122 1.48731e-54 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 Q8BMJ3 289 1.8e-24 Eukaryotic translation initiation factor 1A, X-chromosomal OS=Mus musculus GN=Eif1ax PE=2 SV=3 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.39709 BF_2 59.82 2.45 1309 557767939 XP_005183655.1 515 1.6e-49 PREDICTED: eukaryotic translation initiation factor 1A, X-chromosomal [Musca domestica] 195569934 XM_002102928.1 184 3.02931e-89 Drosophila simulans GD19223 (Dsim\GD19223), mRNA K03236 EIF1A translation initiation factor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K03236 P47815 390 2.1e-36 Eukaryotic translation initiation factor 1A OS=Triticum aestivum PE=1 SV=2 PF01176 Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840 ribosome KOG3403 Translation initiation factor 1A (eIF-1A) Cluster-8309.3971 BF_2 10.00 0.65 926 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39710 BF_2 1682.24 93.73 1038 642916084 XP_008190883.1 1477 3.6e-161 PREDICTED: ribose-phosphate pyrophosphokinase 1 isoform X1 [Tribolium castaneum]>gi|270003720|gb|EFA00168.1| hypothetical protein TcasGA2_TC002990 [Tribolium castaneum] 837814424 XM_012928152.1 234 3.82999e-117 PREDICTED: Ochotona princeps ribose-phosphate pyrophosphokinase 1 (LOC101518950), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 P60892 1264 7.5e-138 Ribose-phosphate pyrophosphokinase 1 OS=Rattus norvegicus GN=Prps1 PE=1 SV=2 PF00156//PF14572 Phosphoribosyl transferase domain//Phosphoribosyl synthetase-associated domain GO:0009116//GO:0006098//GO:0016310//GO:0009165//GO:0009156//GO:0006144 nucleoside metabolic process//pentose-phosphate shunt//phosphorylation//nucleotide biosynthetic process//ribonucleoside monophosphate biosynthetic process//purine nucleobase metabolic process GO:0016301//GO:0000287//GO:0004749 kinase activity//magnesium ion binding//ribose phosphate diphosphokinase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.39711 BF_2 319.17 4.60 3187 546673138 ERL84803.1 2449 2.2e-273 hypothetical protein D910_02228 [Dendroctonus ponderosae] 297804109 XM_002869893.1 59 2.29934e-19 Arabidopsis lyrata subsp. lyrata CTP synthase, mRNA K01937 pyrG, CTPS CTP synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01937 Q2M197 1861 1.4e-206 CTP synthase OS=Drosophila pseudoobscura pseudoobscura GN=CTPsyn PE=3 SV=2 PF00834//PF06418//PF07722 Ribulose-phosphate 3 epimerase family//CTP synthase N-terminus//Peptidase C26 GO:0006221//GO:0006206//GO:0006541//GO:0005975 pyrimidine nucleotide biosynthetic process//pyrimidine nucleobase metabolic process//glutamine metabolic process//carbohydrate metabolic process GO:0016857//GO:0016787//GO:0003883 racemase and epimerase activity, acting on carbohydrates and derivatives//hydrolase activity//CTP synthase activity -- -- KOG2387 CTP synthase (UTP-ammonia lyase) Cluster-8309.39715 BF_2 115.31 1.48 3546 642925776 XP_008201712.1 2274 4.8e-253 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 8.9e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.39716 BF_2 240.00 2.95 3688 91084681 XP_968452.1 2285 2.6e-254 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925779|ref|XP_008201721.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925781|ref|XP_008201727.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925783|ref|XP_008190266.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|270008928|gb|EFA05376.1| hypothetical protein TcasGA2_TC015542 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 9.2e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0044765//GO:0008272 single-organism transport//sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.39717 BF_2 145.00 5.70 1352 566080617 AHC54390.1 1507 1.6e-164 adenine nucleotide translocase 2 [Scylla paramamosain] 566080616 KF709943.1 1333 0 Scylla paramamosain adenine nucleotide translocase 2 (ANT2) mRNA, complete cds K05863 SLC25A4S, ANT solute carrier family 25 (mitochondrial adenine nucleotide translocator), member 4/5/6/31 http://www.genome.jp/dbget-bin/www_bget?ko:K05863 Q26365 1244 2.0e-135 ADP,ATP carrier protein OS=Drosophila melanogaster GN=sesB PE=2 SV=4 -- -- -- -- -- -- -- -- KOG0749 Mitochondrial ADP/ATP carrier proteins Cluster-8309.39718 BF_2 1986.25 29.46 3108 642932516 XP_008197146.1 3187 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B isoform X2 [Tribolium castaneum] 642932515 XM_008198924.1 721 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X3, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 Q03043 2658 5.1e-299 cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B OS=Drosophila melanogaster GN=for PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.39719 BF_2 1854.56 14.84 5515 167234451 NP_001107840.1 4552 0.0e+00 Dicer-2 [Tribolium castaneum]>gi|642913971|ref|XP_008201496.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|642913973|ref|XP_008201497.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|270002830|gb|EEZ99277.1| hypothetical protein TcasGA2_TC001108 [Tribolium castaneum] 642913972 XM_008203275.1 50 4.02651e-14 PREDICTED: Tribolium castaneum Dicer-2 (Dcr-2), transcript variant X2, mRNA -- -- -- -- P34529 1074 4.3e-115 Endoribonuclease dcr-1 OS=Caenorhabditis elegans GN=dcr-1 PE=1 SV=3 PF00270//PF03368//PF02170//PF04851//PF14622//PF00636 DEAD/DEAH box helicase//Dicer dimerisation domain//PAZ domain//Type III restriction enzyme, res subunit//Ribonuclease-III-like//Ribonuclease III domain GO:0016072//GO:0006396//GO:0034470//GO:0051252 rRNA metabolic process//RNA processing//ncRNA processing//regulation of RNA metabolic process GO:0003676//GO:0016891//GO:0043167//GO:0004525//GO:0016787//GO:0003677//GO:0005524//GO:0003723//GO:0004386//GO:0005515 nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters//ion binding//ribonuclease III activity//hydrolase activity//DNA binding//ATP binding//RNA binding//helicase activity//protein binding -- -- KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.39722 BF_2 1035.83 47.01 1209 642934971 XP_008196003.1 515 1.5e-49 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 48 1.11642e-13 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39723 BF_2 4380.00 153.99 1477 399240763 AFP43193.1 288 3.9e-23 Bv80, partial [Babesia bovis]>gi|399240779|gb|AFP43201.1| Bv80, partial [Babesia bovis] -- -- -- -- -- -- -- -- -- O77788 192 2.2e-13 Neurofilament medium polypeptide OS=Bos taurus GN=NEFM PE=1 SV=3 PF01158//PF05748 Ribosomal protein L36e//Rubella membrane glycoprotein E1 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0019013//GO:0005622//GO:0016021//GO:0005840 viral nucleocapsid//intracellular//integral component of membrane//ribosome -- -- Cluster-8309.39725 BF_2 2242.50 14.97 6555 826459786 XP_012533972.1 4760 0.0e+00 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X1 [Monomorium pharaonis] 407731599 JQ771517.1 1604 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4682 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF08686//PF00095//PF00499//PF13895//PF05790//PF04545//PF01545 E1-E2 ATPase//PLAC (protease and lacunin) domain//WAP-type (Whey Acidic Protein) 'four-disulfide core'//NADH-ubiquinone/plastoquinone oxidoreductase chain 6//Immunoglobulin domain//Immunoglobulin C2-set domain//Sigma-70, region 4//Cation efflux family GO:0015992//GO:0055114//GO:0006355//GO:0006812//GO:0006814//GO:0006120//GO:0055085//GO:0006352//GO:0006744//GO:0007155 proton transport//oxidation-reduction process//regulation of transcription, DNA-templated//cation transport//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//transmembrane transport//DNA-templated transcription, initiation//ubiquinone biosynthetic process//cell adhesion GO:0008137//GO:0003700//GO:0030414//GO:0008233//GO:0000166//GO:0008324//GO:0046872//GO:0016987//GO:0005515//GO:0003677 NADH dehydrogenase (ubiquinone) activity//transcription factor activity, sequence-specific DNA binding//peptidase inhibitor activity//peptidase activity//nucleotide binding//cation transmembrane transporter activity//metal ion binding//sigma factor activity//protein binding//DNA binding GO:0016021//GO:0005576//GO:0005667 integral component of membrane//extracellular region//transcription factor complex KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.39726 BF_2 444.74 1.11 17038 826459797 XP_012533974.1 4761 0.0e+00 PREDICTED: sodium/potassium-transporting ATPase subunit alpha isoform X3 [Monomorium pharaonis] 407731599 JQ771517.1 1604 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF08686//PF00095//PF05986//PF13895//PF04545//PF00014//PF02714 E1-E2 ATPase//PLAC (protease and lacunin) domain//WAP-type (Whey Acidic Protein) 'four-disulfide core'//ADAM-TS Spacer 1//Immunoglobulin domain//Sigma-70, region 4//Kunitz/Bovine pancreatic trypsin inhibitor domain//Calcium-dependent channel, 7TM region, putative phosphate GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0004867//GO:0005515//GO:0016987//GO:0046872//GO:0004222//GO:0000166//GO:0003700//GO:0030414//GO:0008233 DNA binding//serine-type endopeptidase inhibitor activity//protein binding//sigma factor activity//metal ion binding//metalloendopeptidase activity//nucleotide binding//transcription factor activity, sequence-specific DNA binding//peptidase inhibitor activity//peptidase activity GO:0031012//GO:0005667//GO:0005576//GO:0016020 extracellular matrix//transcription factor complex//extracellular region//membrane KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.39728 BF_2 25.22 0.42 2806 242015216 XP_002428268.1 1387 2.7e-150 cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis]>gi|212512842|gb|EEB15530.1| cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis] 558203653 XM_006132037.1 59 2.02132e-19 PREDICTED: Pelodiscus sinensis mitogen-activated protein kinase kinase 7 (MAP2K7), partial mRNA K04432 MAP2K3, MKK3 mitogen-activated protein kinase kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04432 O09110 1133 3.1e-122 Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus GN=Map2k3 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.39729 BF_2 125.38 0.49 10907 91088841 XP_970807.1 2162 1.4e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.92955e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 6.3e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF00538//PF01853//PF00628//PF01160//PF06431//PF13508 linker histone H1 and H5 family//MOZ/SAS family//PHD-finger//Vertebrate endogenous opioids neuropeptide//Polyomavirus large T antigen C-terminus//Acetyltransferase (GNAT) domain GO:0007218//GO:0006260//GO:0006355//GO:0006334//GO:0042967 neuropeptide signaling pathway//DNA replication//regulation of transcription, DNA-templated//nucleosome assembly//acyl-carrier-protein biosynthetic process GO:0005488//GO:0016747//GO:0003677//GO:0005524//GO:0005515//GO:0008080 binding//transferase activity, transferring acyl groups other than amino-acyl groups//DNA binding//ATP binding//protein binding//N-acetyltransferase activity GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.39731 BF_2 458.23 1.69 11612 642936312 XP_008198391.1 6744 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 1.00338e-77 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3329 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF00018//PF14604//PF07651//PF01608//PF03822 SH3 domain//Variant SH3 domain//ANTH domain//I/LWEQ domain//NAF domain GO:0007165 signal transduction GO:0005543//GO:0003779//GO:0005515 phospholipid binding//actin binding//protein binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.39732 BF_2 314.44 1.19 11307 642936312 XP_008198391.1 8147 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 9.76939e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3605 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF14604//PF00018//PF07651//PF01608//PF03822 Variant SH3 domain//SH3 domain//ANTH domain//I/LWEQ domain//NAF domain GO:0007165 signal transduction GO:0003779//GO:0005515//GO:0005543 actin binding//protein binding//phospholipid binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.39733 BF_2 23.07 0.33 3214 642939027 XP_008200193.1 2676 1.0e-299 PREDICTED: puromycin-sensitive aminopeptidase-like protein [Tribolium castaneum] 195336597 XM_002034886.1 288 1.16121e-146 Drosophila sechellia GM14417 (Dsec\GM14417), mRNA K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 P55786 1995 4.0e-222 Puromycin-sensitive aminopeptidase OS=Homo sapiens GN=NPEPPS PE=1 SV=2 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.39734 BF_2 3427.39 58.38 2743 642939027 XP_008200193.1 3110 0.0e+00 PREDICTED: puromycin-sensitive aminopeptidase-like protein [Tribolium castaneum] 195336597 XM_002034886.1 293 1.64346e-149 Drosophila sechellia GM14417 (Dsec\GM14417), mRNA K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 P55786 2207 8.9e-247 Puromycin-sensitive aminopeptidase OS=Homo sapiens GN=NPEPPS PE=1 SV=2 PF03814//PF01433 Potassium-transporting ATPase A subunit//Peptidase family M1 GO:0006813 potassium ion transport GO:0008556//GO:0008270//GO:0008237 potassium-transporting ATPase activity//zinc ion binding//metallopeptidase activity GO:0005886 plasma membrane KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.39736 BF_2 376.31 2.99 5554 91094499 XP_971436.1 1171 5.9e-125 PREDICTED: phosphopantothenate--cysteine ligase [Tribolium castaneum]>gi|270000749|gb|EEZ97196.1| hypothetical protein TcasGA2_TC004384 [Tribolium castaneum] -- -- -- -- -- K01922 PPCS, coaB phosphopantothenate-cysteine ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01922 Q9HAB8 579 1.1e-57 Phosphopantothenate--cysteine ligase OS=Homo sapiens GN=PPCS PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2728 Uncharacterized conserved protein with similarity to phosphopantothenoylcysteine synthetase/decarboxylase Cluster-8309.39737 BF_2 282.24 2.40 5207 91084043 XP_967085.1 2172 4.7e-241 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 239 3.27553e-119 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1834 3.0e-203 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF10415//PF00491 Fumarase C C-terminus//Arginase family GO:0019643//GO:0006106//GO:0006099 reductive tricarboxylic acid cycle//fumarate metabolic process//tricarboxylic acid cycle GO:0004333//GO:0016829//GO:0046872 fumarate hydratase activity//lyase activity//metal ion binding GO:0045239 tricarboxylic acid cycle enzyme complex KOG1317 Fumarase Cluster-8309.39739 BF_2 4001.59 34.74 5105 91084043 XP_967085.1 2172 4.6e-241 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 239 3.21092e-119 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1834 3.0e-203 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF10415//PF00491//PF01607 Fumarase C C-terminus//Arginase family//Chitin binding Peritrophin-A domain GO:0006106//GO:0006099//GO:0019643//GO:0006030 fumarate metabolic process//tricarboxylic acid cycle//reductive tricarboxylic acid cycle//chitin metabolic process GO:0008061//GO:0004333//GO:0016829//GO:0046872 chitin binding//fumarate hydratase activity//lyase activity//metal ion binding GO:0045239//GO:0005576 tricarboxylic acid cycle enzyme complex//extracellular region KOG1317 Fumarase Cluster-8309.39742 BF_2 5734.20 28.77 8624 270012222 EFA08670.1 2246 2.0e-249 hypothetical protein TcasGA2_TC006336 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 413 3.0e-38 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF06974//PF03007//PF07690//PF01277 Protein of unknown function (DUF1298)//Wax ester synthase-like Acyl-CoA acyltransferase domain//Major Facilitator Superfamily//Oleosin GO:0046486//GO:0042967//GO:0045017//GO:0055085 glycerolipid metabolic process//acyl-carrier-protein biosynthetic process//glycerolipid biosynthetic process//transmembrane transport GO:0004144 diacylglycerol O-acyltransferase activity GO:0016021//GO:0012511 integral component of membrane//monolayer-surrounded lipid storage body KOG2504 Monocarboxylate transporter Cluster-8309.39745 BF_2 144.70 1.18 5424 270011060 EFA07508.1 3837 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1226 1.0e-132 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF01483//PF00207//PF07678//PF07677//PF01835 Proprotein convertase P-domain//Alpha-2-macroglobulin family//A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain GO:0006508 proteolysis GO:0004866//GO:0004252 endopeptidase inhibitor activity//serine-type endopeptidase activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.39747 BF_2 4.81 0.55 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39748 BF_2 277.96 3.10 4036 642933107 XP_008197261.1 1670 5.9e-183 PREDICTED: prominin-like protein isoform X1 [Tribolium castaneum]>gi|270011437|gb|EFA07885.1| hypothetical protein TcasGA2_TC005459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 530 3.8e-52 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF07926//PF02417//PF07464//PF13903//PF04513//PF01442//PF05478//PF05356 TPR/MLP1/MLP2-like protein//Chromate transporter//Apolipophorin-III precursor (apoLp-III)//PMP-22/EMP/MP20/Claudin tight junction//Baculovirus polyhedron envelope protein, PEP, C terminus//Apolipoprotein A1/A4/E domain//Prominin//Phage Coat protein B GO:0006606//GO:0015703//GO:0042157//GO:0006869 protein import into nucleus//chromate transport//lipoprotein metabolic process//lipid transport GO:0015109//GO:0008289//GO:0005198 chromate transmembrane transporter activity//lipid binding//structural molecule activity GO:0005576//GO:0019028//GO:0016021//GO:0019031 extracellular region//viral capsid//integral component of membrane//viral envelope KOG4331 Polytopic membrane protein Prominin Cluster-8309.39749 BF_2 677.16 30.27 1223 91081289 XP_968282.1 617 2.3e-61 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270006089|gb|EFA02537.1| hypothetical protein TcasGA2_TC008242 [Tribolium castaneum] -- -- -- -- -- K06537 CD151, TSPAN24 CD151 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06537 O35566 442 1.8e-42 CD151 antigen OS=Mus musculus GN=Cd151 PE=2 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.39750 BF_2 4181.52 85.46 2334 91080723 XP_975387.1 1549 3.7e-169 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q2KJ58 583 1.6e-58 Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus GN=RAB3IL1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39751 BF_2 39.64 0.70 2648 91087475 XP_967673.1 2015 3.8e-223 PREDICTED: 26S protease regulatory subunit 6A-B [Tribolium castaneum]>gi|270010662|gb|EFA07110.1| hypothetical protein TcasGA2_TC010100 [Tribolium castaneum] 54287935 AY750868.1 407 0 Toxoptera citricida putative 26S protease regulatory subunit 6A mRNA, complete cds K03065 PSMC3, RPT5 26S proteasome regulatory subunit T5 http://www.genome.jp/dbget-bin/www_bget?ko:K03065 O88685 1805 3.5e-200 26S protease regulatory subunit 6A OS=Mus musculus GN=Psmc3 PE=1 SV=2 PF00910//PF00005//PF02562//PF00004//PF07724//PF01695//PF07728//PF05496//PF00158 RNA helicase//ABC transporter//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain GO:0006281//GO:0006355//GO:0006310//GO:0030163 DNA repair//regulation of transcription, DNA-templated//DNA recombination//protein catabolic process GO:0005524//GO:0003723//GO:0008134//GO:0016887//GO:0009378//GO:0017111//GO:0003724 ATP binding//RNA binding//transcription factor binding//ATPase activity//four-way junction helicase activity//nucleoside-triphosphatase activity//RNA helicase activity GO:0009379//GO:0005657//GO:0005667//GO:0005737 Holliday junction helicase complex//replication fork//transcription factor complex//cytoplasm KOG0652 26S proteasome regulatory complex, ATPase RPT5 Cluster-8309.39753 BF_2 123.55 38.41 421 91092422 XP_968009.1 638 2.9e-64 PREDICTED: ATP-binding cassette sub-family E member 1 [Tribolium castaneum]>gi|642917265|ref|XP_008199227.1| PREDICTED: ATP-binding cassette sub-family E member 1 [Tribolium castaneum]>gi|270004744|gb|EFA01192.1| hypothetical protein TcasGA2_TC010519 [Tribolium castaneum] -- -- -- -- -- K06174 ABCE1 ATP-binding cassette, sub-family E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06174 P61221 543 1.2e-54 ATP-binding cassette sub-family E member 1 OS=Homo sapiens GN=ABCE1 PE=1 SV=1 PF00005//PF13304 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006200//GO:0006118 obsolete ATP catabolic process//obsolete electron transport GO:0009055//GO:0051536//GO:0005524//GO:0016887 electron carrier activity//iron-sulfur cluster binding//ATP binding//ATPase activity -- -- KOG0063 RNAse L inhibitor, ABC superfamily Cluster-8309.39754 BF_2 8.23 0.39 1168 91079574 XP_966886.1 841 2.3e-87 PREDICTED: ubiquitin carboxyl-terminal hydrolase [Tribolium castaneum]>gi|270004456|gb|EFA00904.1| hypothetical protein TcasGA2_TC003809 [Tribolium castaneum] -- -- -- -- -- K05609 UCHL3, YUH1 ubiquitin carboxyl-terminal hydrolase L3 http://www.genome.jp/dbget-bin/www_bget?ko:K05609 P35122 548 8.9e-55 Ubiquitin carboxyl-terminal hydrolase OS=Drosophila melanogaster GN=Uch PE=2 SV=2 PF01088 Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0006511//GO:0006508//GO:0016579 ubiquitin-dependent protein catabolic process//proteolysis//protein deubiquitination GO:0004221//GO:0004843 obsolete ubiquitin thiolesterase activity//ubiquitin-specific protease activity GO:0005622 intracellular KOG1415 Ubiquitin C-terminal hydrolase UCHL1 Cluster-8309.39755 BF_2 947.46 2.91 13895 270013752 EFA10200.1 800 1.6e-81 hypothetical protein TcasGA2_TC012395 [Tribolium castaneum] 642934667 XM_008199538.1 207 5.39477e-101 PREDICTED: Tribolium castaneum nuclear receptor-binding protein homolog (LOC661173), mRNA K08875 NRBP nuclear receptor-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08875 Q297L2 566 8.7e-56 Nuclear receptor-binding protein homolog OS=Drosophila pseudoobscura pseudoobscura GN=Madm PE=3 SV=2 PF01365//PF00767//PF07714//PF01529//PF00069 RIH domain//Potyvirus coat protein//Protein tyrosine kinase//DHHC palmitoyltransferase//Protein kinase domain GO:0006816//GO:0006468//GO:0070588 calcium ion transport//protein phosphorylation//calcium ion transmembrane transport GO:0005524//GO:0005262//GO:0008270//GO:0004672 ATP binding//calcium channel activity//zinc ion binding//protein kinase activity GO:0019028//GO:0016020 viral capsid//membrane KOG1266 Protein kinase Cluster-8309.39756 BF_2 213.20 5.93 1791 642934668 XP_008197760.1 2040 3.3e-226 PREDICTED: nuclear receptor-binding protein homolog [Tribolium castaneum] 642934667 XM_008199538.1 588 0 PREDICTED: Tribolium castaneum nuclear receptor-binding protein homolog (LOC661173), mRNA K08875 NRBP nuclear receptor-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K08875 Q9Y0Y6 1362 5.6e-149 Nuclear receptor-binding protein homolog OS=Drosophila melanogaster GN=Madm PE=1 SV=1 PF01365//PF07714//PF00069 RIH domain//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0070588//GO:0006816 protein phosphorylation//calcium ion transmembrane transport//calcium ion transport GO:0004672//GO:0005262//GO:0005524 protein kinase activity//calcium channel activity//ATP binding GO:0016020 membrane KOG1266 Protein kinase Cluster-8309.39757 BF_2 589.86 3.58 7180 642918063 XP_008193852.1 6447 0.0e+00 PREDICTED: nucleoprotein TPR isoform X3 [Tribolium castaneum] -- -- -- -- -- K09291 TPR, MLP1, MLP2 nucleoprotein TPR http://www.genome.jp/dbget-bin/www_bget?ko:K09291 A1Z8P9 2086 2.5e-232 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07926//PF02186//PF05294//PF06005//PF07544 TPR/MLP1/MLP2-like protein//TFIIE beta subunit core domain//Scorpion short toxin//Protein of unknown function (DUF904)//RNA polymerase II transcription mediator complex subunit 9 GO:0009405//GO:0043093//GO:0000917//GO:0006367//GO:0006357//GO:0006606 pathogenesis//FtsZ-dependent cytokinesis//barrier septum assembly//transcription initiation from RNA polymerase II promoter//regulation of transcription from RNA polymerase II promoter//protein import into nucleus GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005737//GO:0005576 mediator complex//cytoplasm//extracellular region KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.39758 BF_2 2036.28 11.76 7528 642918059 XP_008193846.1 6819 0.0e+00 PREDICTED: nucleoprotein TPR isoform X1 [Tribolium castaneum] -- -- -- -- -- K09291 TPR, MLP1, MLP2 nucleoprotein TPR http://www.genome.jp/dbget-bin/www_bget?ko:K09291 A1Z8P9 2086 2.6e-232 Nucleoprotein TPR OS=Drosophila melanogaster GN=Mtor PE=1 SV=1 PF07926//PF02186//PF06005//PF05294//PF07544 TPR/MLP1/MLP2-like protein//TFIIE beta subunit core domain//Protein of unknown function (DUF904)//Scorpion short toxin//RNA polymerase II transcription mediator complex subunit 9 GO:0009405//GO:0006367//GO:0043093//GO:0000917//GO:0006357//GO:0006606 pathogenesis//transcription initiation from RNA polymerase II promoter//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of transcription from RNA polymerase II promoter//protein import into nucleus GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592//GO:0005737//GO:0005576 mediator complex//cytoplasm//extracellular region KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.39760 BF_2 1401.60 9.82 6257 157111277 XP_001651466.1 5403 0.0e+00 AAEL005801-PA [Aedes aegypti]>gi|108878460|gb|EAT42685.1| AAEL005801-PA [Aedes aegypti] 170063636 XM_001867153.1 194 4.08059e-94 Culex quinquefasciatus bifunctional aminoacyl-tRNA synthetase, mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 5247 0.0e+00 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF03950//PF00749//PF00587//PF00992//PF00458//PF09180//PF02146 tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetases class I (E and Q), catalytic domain//tRNA synthetase class II core domain (G, H, P, S and T)//Troponin//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Sir2 family GO:0006525//GO:0006560//GO:0006418//GO:0006433//GO:0043039 arginine metabolic process//proline metabolic process//tRNA aminoacylation for protein translation//prolyl-tRNA aminoacylation//tRNA aminoacylation GO:0005524//GO:0070403//GO:0000166//GO:0004827//GO:0016876//GO:0004812 ATP binding//NAD+ binding//nucleotide binding//proline-tRNA ligase activity//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity GO:0005737//GO:0005861 cytoplasm//troponin complex KOG4163 Prolyl-tRNA synthetase Cluster-8309.39761 BF_2 786.62 16.01 2342 546678697 ERL89265.1 1371 1.6e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 2.9e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.39768 BF_2 2549.59 14.14 7829 91093216 XP_966931.1 11969 0.0e+00 PREDICTED: pre-mRNA-processing-splicing factor 8 [Tribolium castaneum]>gi|270016589|gb|EFA13035.1| hypothetical protein TcasGA2_TC010565 [Tribolium castaneum] 642938178 XM_961838.2 2578 0 PREDICTED: Tribolium castaneum pre-mRNA-processing-splicing factor 8 (LOC655310), mRNA K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12856 Q6P2Q9 11264 0.0e+00 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 PF08082//PF01398//PF08083//PF10596//PF10597//PF10598 PRO8NT (NUC069), PrP8 N-terminal domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//PROCN (NUC071) domain//U6-snRNA interacting domain of PrP8//U5-snRNA binding site 2 of PrP8//RNA recognition motif of the spliceosomal PrP8 GO:0000398 mRNA splicing, via spliceosome GO:0030623//GO:0005515//GO:0017070//GO:0003723 U5 snRNA binding//protein binding//U6 snRNA binding//RNA binding GO:0005681 spliceosomal complex KOG1795 U5 snRNP spliceosome subunit Cluster-8309.39769 BF_2 58.10 1.17 2363 91090912 XP_973979.1 279 6.8e-22 PREDICTED: troponin C, isoform 2 [Tribolium castaneum]>gi|270014010|gb|EFA10458.1| hypothetical protein TcasGA2_TC012704 [Tribolium castaneum] 642936036 XM_968886.2 90 9.94191e-37 PREDICTED: Tribolium castaneum troponin C, isoform 2 (LOC662809), mRNA -- -- -- -- P47949 252 3.8e-20 Troponin C, isoform 3 OS=Drosophila melanogaster GN=TpnC73F PE=2 SV=2 PF13405//PF00036//PF13499 EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.39770 BF_2 385.00 13.06 1520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39773 BF_2 536.21 6.77 3601 332376741 AEE63510.1 1257 4.1e-135 unknown [Dendroctonus ponderosae] 665817218 XM_008559146.1 65 1.2018e-22 PREDICTED: Microplitis demolitor glycine N-methyltransferase-like (LOC103578165), mRNA K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q29513 847 5.9e-89 Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1 PF01209//PF05724//PF01135//PF05175//PF08241 ubiE/COQ5 methyltransferase family//Thiopurine S-methyltransferase (TPMT)//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Methyltransferase domain GO:0006479//GO:0006464//GO:0008152//GO:0046500 protein methylation//cellular protein modification process//metabolic process//S-adenosylmethionine metabolic process GO:0004719//GO:0008757//GO:0008168 protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//methyltransferase activity -- -- -- -- Cluster-8309.39777 BF_2 1161.00 107.49 739 290909031 ADD70030.1 525 6.4e-51 minus-C odorant binding protein 1 [Batocera horsfieldi] 290909030 GU575294.1 294 1.19079e-150 Batocera horsfieldi minus-C odorant binding protein 1 mRNA, complete cds -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.39778 BF_2 713.33 4.83 6471 642918222 XP_008191418.1 7103 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X1 [Tribolium castaneum]>gi|270003291|gb|EEZ99738.1| hypothetical protein TcasGA2_TC002507 [Tribolium castaneum] 795022714 XM_012005302.1 605 0 PREDICTED: Vollenhovia emeryi transcription initiation factor TFIID subunit 1 (LOC105557903), mRNA K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 Q8IZX4 3987 0.0e+00 Transcription initiation factor TFIID subunit 1-like OS=Homo sapiens GN=TAF1L PE=1 SV=1 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.39779 BF_2 1057.24 7.06 6554 270002717 EEZ99164.1 9779 0.0e+00 hypothetical protein TcasGA2_TC016163 [Tribolium castaneum] 642912219 XM_965461.2 1827 0 PREDICTED: Tribolium castaneum putative U5 small nuclear ribonucleoprotein 200 kDa helicase (LOC659129), mRNA K12854 SNRNP200, BRR2 pre-mRNA-splicing helicase BRR2 http://www.genome.jp/dbget-bin/www_bget?ko:K12854 Q9VUV9 8701 0.0e+00 Putative U5 small nuclear ribonucleoprotein 200 kDa helicase OS=Drosophila melanogaster GN=l(3)72Ab PE=2 SV=4 PF00437//PF01695//PF03412//PF03146//PF00270//PF00580//PF02562//PF04851 Type II/IV secretion system protein//IstB-like ATP binding protein//Peptidase C39 family//Agrin NtA domain//DEAD/DEAH box helicase//UvrD/REP helicase N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit GO:0043113//GO:0006508//GO:0007213//GO:0006810 receptor clustering//proteolysis//G-protein coupled acetylcholine receptor signaling pathway//transport GO:0003676//GO:0008233//GO:0005524//GO:0016787//GO:0003677//GO:0043236 nucleic acid binding//peptidase activity//ATP binding//hydrolase activity//DNA binding//laminin binding GO:0016021 integral component of membrane KOG0951 RNA helicase BRR2, DEAD-box superfamily Cluster-8309.3978 BF_2 39.00 1.07 1818 642913372 XP_008195444.1 1031 3.3e-109 PREDICTED: protein SHQ1 homolog [Tribolium castaneum]>gi|270001737|gb|EEZ98184.1| hypothetical protein TcasGA2_TC000613 [Tribolium castaneum] -- -- -- -- -- K14764 SHQ1 protein SHQ1 http://www.genome.jp/dbget-bin/www_bget?ko:K14764 Q3MHH1 531 1.3e-52 Protein SHQ1 homolog OS=Bos taurus GN=SHQ1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3247 Uncharacterized conserved protein Cluster-8309.39781 BF_2 124.00 9.01 863 642914186 XP_008201580.1 216 5.0e-15 PREDICTED: uncharacterized protein LOC661670 isoform X1 [Tribolium castaneum]>gi|270002176|gb|EEZ98623.1| hypothetical protein TcasGA2_TC001146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03802 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase GO:0051191 prosthetic group biosynthetic process -- -- -- -- -- -- Cluster-8309.39782 BF_2 995.96 18.63 2524 859132804 AKO63317.1 1918 6.5e-212 3-hydroxy-3-methylglutaryl coenzyme A synthase [Leptinotarsa decemlineata] -- -- -- -- -- K01641 E2.3.3.10 hydroxymethylglutaryl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01641 P54961 1642 2.7e-181 Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella germanica GN=HMGCS-1 PE=2 SV=1 PF01154//PF08540 Hydroxymethylglutaryl-coenzyme A synthase N terminal//Hydroxymethylglutaryl-coenzyme A synthase C terminal GO:0006552//GO:0008299//GO:0046950//GO:0006084//GO:0006574//GO:0006550 leucine catabolic process//isoprenoid biosynthetic process//cellular ketone body metabolic process//acetyl-CoA metabolic process//valine catabolic process//isoleucine catabolic process GO:0004421 hydroxymethylglutaryl-CoA synthase activity -- -- KOG1393 Hydroxymethylglutaryl-CoA synthase Cluster-8309.39783 BF_2 74.01 0.68 4833 642923742 XP_966686.2 2852 0.0e+00 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X9 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O95573 1652 3.6e-182 Long-chain-fatty-acid--CoA ligase 3 OS=Homo sapiens GN=ACSL3 PE=1 SV=3 PF00501//PF00908 AMP-binding enzyme//dTDP-4-dehydrorhamnose 3,5-epimerase GO:0030639//GO:0008152//GO:0019872//GO:0009117 polyketide biosynthetic process//metabolic process//streptomycin biosynthetic process//nucleotide metabolic process GO:0008830//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//catalytic activity -- -- KOG1180 Acyl-CoA synthetase Cluster-8309.39784 BF_2 836.28 11.81 3250 642922869 XP_008200431.1 2031 6.6e-225 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1465 1.2e-160 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00236//PF00005//PF03193//PF00664//PF01926//PF13304 Glycoprotein hormone//ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0007165//GO:0006810 transmembrane transport//signal transduction//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924//GO:0005179 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.39786 BF_2 729.19 12.32 2764 642922865 XP_008200429.1 3170 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum]>gi|642922867|ref|XP_008200430.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 isoform X1 [Tribolium castaneum] 768439826 XM_011563263.1 40 7.26175e-09 PREDICTED: Plutella xylostella probable multidrug resistance-associated protein lethal(2)03659 (LOC105391726), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1489 1.6e-163 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF00664//PF13304 ABC transporter//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0005524//GO:0042626 ATPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.39787 BF_2 807.22 6.26 5680 642939895 XP_008200229.1 2663 6.0e-298 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] 657546453 XM_008280188.1 50 4.14777e-14 PREDICTED: Stegastes partitus protein tyrosine phosphatase, non-receptor type 6 (ptpn6), mRNA K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q06124 1888 1.8e-209 Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens GN=PTPN11 PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes Cluster-8309.39792 BF_2 2136.50 12.79 7276 642935187 XP_008199684.1 1340 2.0e-144 PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|642935189|ref|XP_008199685.1| PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|270014202|gb|EFA10650.1| hypothetical protein TcasGA2_TC016287 [Tribolium castaneum] 558226116 XM_006137153.1 62 1.13503e-20 PREDICTED: Pelodiscus sinensis tetratricopeptide repeat domain 1 (TTC1), transcript variant X3, mRNA K12386 CTNS cystinosin http://www.genome.jp/dbget-bin/www_bget?ko:K12386 Q9VCR7 1014 5.1e-108 Cystinosin homolog OS=Drosophila melanogaster GN=CG17119 PE=1 SV=2 PF13174//PF13181//PF00522//PF13414//PF04194//PF13176//PF13374//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//VPR/VPX protein//TPR repeat//Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0005515 protein binding GO:0005737//GO:0042025 cytoplasm//host cell nucleus KOG3145 Cystine transporter Cystinosin Cluster-8309.39794 BF_2 669.26 164.52 457 642922291 XP_008193096.1 649 1.6e-65 PREDICTED: uncharacterized protein LOC661530 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02270 Transcription initiation factor IIF, beta subunit GO:0006366//GO:0006367 transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter -- -- GO:0005674 transcription factor TFIIF complex -- -- Cluster-8309.39795 BF_2 152.85 0.75 8794 546684662 ERL94279.1 3287 0.0e+00 hypothetical protein D910_11560 [Dendroctonus ponderosae] 642911060 XM_008202336.1 483 0 PREDICTED: Tribolium castaneum muscle calcium channel subunit alpha-1-like (LOC659557), mRNA K05315 CACNA1N voltage-dependent calcium channel alpha 1, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05315 Q24270 2747 6.9e-309 Voltage-dependent calcium channel type D subunit alpha-1 OS=Drosophila melanogaster GN=Ca-alpha1D PE=1 SV=2 PF00813//PF00520//PF05887 FliP family//Ion transport protein//Procyclic acidic repetitive protein (PARP) GO:0006811//GO:0009306//GO:0055085 ion transport//protein secretion//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.39796 BF_2 84.00 0.69 5381 642922291 XP_008193096.1 1316 8.8e-142 PREDICTED: uncharacterized protein LOC661530 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00253 IVD, ivd isovaleryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00253 P12007 1016 2.2e-108 Isovaleryl-CoA dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Ivd PE=1 SV=2 PF00595//PF13180//PF04179//PF02771//PF02770//PF00441//PF02270 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Initiator tRNA phosphoribosyl transferase//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain//Transcription initiation factor IIF, beta subunit GO:0055114//GO:0006367//GO:0006118//GO:0019988//GO:0006366//GO:0008152 oxidation-reduction process//transcription initiation from RNA polymerase II promoter//obsolete electron transport//charged-tRNA amino acid modification//transcription from RNA polymerase II promoter//metabolic process GO:0016627//GO:0050660//GO:0005515//GO:0003995//GO:0043399 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//protein binding//acyl-CoA dehydrogenase activity//tRNA A64-2'-O-ribosylphosphate transferase activity GO:0005674 transcription factor TFIIF complex KOG0141 Isovaleryl-CoA dehydrogenase Cluster-8309.39801 BF_2 193.19 2.76 3220 546682247 ERL92208.1 1592 5.2e-174 hypothetical protein D910_09528, partial [Dendroctonus ponderosae] -- -- -- -- -- K08200 SLC22A3, OCT3 MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08200 Q9VCA2 648 6.2e-66 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF08573//PF07578//PF07690//PF00083 DNA repair protein endonuclease SAE2/CtIP C-terminus//Lipid A Biosynthesis N-terminal domain//Major Facilitator Superfamily//Sugar (and other) transporter GO:0006281//GO:0055085//GO:0009245//GO:0006308//GO:0000077 DNA repair//transmembrane transport//lipid A biosynthetic process//DNA catabolic process//DNA damage checkpoint GO:0022857//GO:0008915//GO:0000014 transmembrane transporter activity//lipid-A-disaccharide synthase activity//single-stranded DNA endodeoxyribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.39806 BF_2 85.68 0.89 4325 642912938 XP_008201315.1 858 9.1e-89 PREDICTED: antichymotrypsin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P80034 546 5.6e-54 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 PF01080//PF07225 Presenilin//NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) GO:0015992//GO:0006744//GO:0006814//GO:0006120 proton transport//ubiquinone biosynthetic process//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0004190 NADH dehydrogenase (ubiquinone) activity//aspartic-type endopeptidase activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane -- -- Cluster-8309.39807 BF_2 742.86 32.48 1244 642912419 XP_008193351.1 596 6.3e-59 PREDICTED: uncharacterized protein LOC103313009 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39808 BF_2 122.01 2.41 2404 270001539 EEZ97986.1 1963 3.7e-217 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 364 0 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1031 1.8e-110 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.39809 BF_2 41.89 0.45 4199 270001539 EEZ97986.1 2008 3.9e-222 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 9.09024e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 5.9e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.3981 BF_2 11.59 0.32 1810 332373040 AEE61661.1 1291 2.3e-139 unknown [Dendroctonus ponderosae]>gi|478250242|gb|ENN70742.1| hypothetical protein YQE_12531, partial [Dendroctonus ponderosae]>gi|546685939|gb|ERL95353.1| hypothetical protein D910_12618 [Dendroctonus ponderosae] -- -- -- -- -- K03142 TFIIH2, GTF2H2, SSL1 transcription initiation factor TFIIH subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03142 Q2TBV5 828 4.7e-87 General transcription factor IIH subunit 2 OS=Bos taurus GN=GTF2H2 PE=2 SV=1 PF01363//PF07649//PF07975 FYVE zinc finger//C1-like domain//TFIIH C1-like domain GO:0006281//GO:0055114 DNA repair//oxidation-reduction process GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG2807 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit SSL1 Cluster-8309.39810 BF_2 69.63 2.67 1379 642935173 XP_008199677.1 518 7.7e-50 PREDICTED: elongation of very long chain fatty acids protein 7 [Tribolium castaneum]>gi|270014194|gb|EFA10642.1| hypothetical protein TcasGA2_TC016279 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1HRV8 330 2.0e-29 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39812 BF_2 538.49 5.22 4600 91092690 XP_971771.1 1734 2.6e-190 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 5.04748e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 888 1.3e-93 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.39813 BF_2 152.53 4.15 1824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03975 CheD chemotactic sensory transduction GO:0006935//GO:0006807 chemotaxis//nitrogen compound metabolic process GO:0050568 protein-glutamine glutaminase activity -- -- -- -- Cluster-8309.39814 BF_2 3966.36 33.72 5207 91092436 XP_968632.1 5905 0.0e+00 PREDICTED: laminin subunit gamma-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05635 LAMC1 laminin, gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05635 P15215 4317 0.0e+00 Laminin subunit gamma-1 OS=Drosophila melanogaster GN=LanB2 PE=2 SV=2 PF06008//PF01466//PF02346 Laminin Domain I//Skp1 family, dimerisation domain//Chordopoxvirus multifunctional envelope protein A27 GO:0045995//GO:0006511//GO:0030155//GO:0019064//GO:0007165//GO:0030334 regulation of embryonic development//ubiquitin-dependent protein catabolic process//regulation of cell adhesion//fusion of virus membrane with host plasma membrane//signal transduction//regulation of cell migration GO:0005102 receptor binding GO:0019031 viral envelope KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.39816 BF_2 1885.62 14.02 5914 642914669 XP_008190307.1 3036 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.25905e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39818 BF_2 151.26 1.44 4675 91078972 XP_974414.1 2664 3.8e-298 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum]>gi|270004163|gb|EFA00611.1| hypothetical protein TcasGA2_TC003486 [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1610 2.6e-177 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.39819 BF_2 216.03 3.62 2781 642933817 XP_008197388.1 565 5.5e-55 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.3982 BF_2 5.00 0.39 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39820 BF_2 316.53 12.17 1375 91079218 XP_970039.1 1033 1.5e-109 PREDICTED: peroxisomal biogenesis factor 3 [Tribolium castaneum]>gi|270003587|gb|EFA00035.1| hypothetical protein TcasGA2_TC002842 [Tribolium castaneum] -- -- -- -- -- K13336 PEX3 peroxin-3 http://www.genome.jp/dbget-bin/www_bget?ko:K13336 Q9JJK4 490 5.6e-48 Peroxisomal biogenesis factor 3 OS=Rattus norvegicus GN=Pex3 PE=1 SV=1 PF04882 Peroxin-3 GO:0007031 peroxisome organization -- -- GO:0005779 integral component of peroxisomal membrane KOG4444 Peroxisomal assembly protein PEX3 Cluster-8309.39823 BF_2 1481.35 43.46 1713 642931553 XP_966693.3 2164 1.3e-240 PREDICTED: V-type proton ATPase subunit H isoform X1 [Tribolium castaneum]>gi|629511289|gb|AHY84718.1| V-type proton ATPase subunit H variant-1 [Tribolium castaneum] 642931552 XM_961600.3 449 0 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1824 1.4e-202 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF02985//PF01602//PF11698//PF00514 HEAT repeat//Adaptin N terminal region//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0016192//GO:0015991//GO:0006886 vesicle-mediated transport//ATP hydrolysis coupled proton transport//intracellular protein transport GO:0005515//GO:0016820 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0000221 membrane coat//vacuolar proton-transporting V-type ATPase, V1 domain KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.39824 BF_2 2782.46 26.02 4760 91087995 XP_973673.1 4127 0.0e+00 PREDICTED: protein transport protein Sec31A [Tribolium castaneum] -- -- -- -- -- K14005 SEC31 protein transport protein SEC31 http://www.genome.jp/dbget-bin/www_bget?ko:K14005 Q7SYD5 1892 5.2e-210 Protein transport protein Sec31A OS=Danio rerio GN=sec31a PE=2 SV=1 PF05008//PF00400//PF02840//PF07904//PF00830 Vesicle transport v-SNARE protein N-terminus//WD domain, G-beta repeat//Prp18 domain//Chromatin modification-related protein EAF7//Ribosomal L28 family GO:0042254//GO:0006355//GO:0006886//GO:0008380 ribosome biogenesis//regulation of transcription, DNA-templated//intracellular protein transport//RNA splicing GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0016020//GO:0005840//GO:0043189//GO:0005681//GO:0005634 membrane//ribosome//H4/H2A histone acetyltransferase complex//spliceosomal complex//nucleus KOG0307 Vesicle coat complex COPII, subunit SEC31 Cluster-8309.39825 BF_2 1147.51 10.53 4846 91087995 XP_973673.1 4127 0.0e+00 PREDICTED: protein transport protein Sec31A [Tribolium castaneum] -- -- -- -- -- K14005 SEC31 protein transport protein SEC31 http://www.genome.jp/dbget-bin/www_bget?ko:K14005 Q7SYD5 1892 5.3e-210 Protein transport protein Sec31A OS=Danio rerio GN=sec31a PE=2 SV=1 PF07904//PF02840//PF00830//PF05008//PF00400 Chromatin modification-related protein EAF7//Prp18 domain//Ribosomal L28 family//Vesicle transport v-SNARE protein N-terminus//WD domain, G-beta repeat GO:0006886//GO:0008380//GO:0006355//GO:0042254 intracellular protein transport//RNA splicing//regulation of transcription, DNA-templated//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005634//GO:0043189//GO:0005681//GO:0016020//GO:0005840 nucleus//H4/H2A histone acetyltransferase complex//spliceosomal complex//membrane//ribosome KOG0307 Vesicle coat complex COPII, subunit SEC31 Cluster-8309.39826 BF_2 33.69 0.74 2197 532107609 XP_005338536.1 462 3.8e-43 PREDICTED: zinc finger protein 420-like [Ictidomys tridecemlineatus] -- -- -- -- -- -- -- -- -- Q9UJU3 424 4.0e-40 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF10392//PF00096//PF07975//PF13465//PF05485//PF16622//PF13912//PF01363 Golgi transport complex subunit 5//Zinc finger, C2H2 type//TFIIH C1-like domain//Zinc-finger double domain//THAP domain//zinc-finger C2H2-type//C2H2-type zinc finger//FYVE zinc finger GO:0006281//GO:0006891 DNA repair//intra-Golgi vesicle-mediated transport GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0017119 Golgi transport complex -- -- Cluster-8309.39827 BF_2 612.98 21.92 1457 642922240 XP_008193073.1 1363 8.5e-148 PREDICTED: sodium/potassium-transporting ATPase subunit beta-2 isoform X1 [Tribolium castaneum]>gi|270007452|gb|EFA03900.1| hypothetical protein TcasGA2_TC014030 [Tribolium castaneum] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24048 932 3.3e-99 Sodium/potassium-transporting ATPase subunit beta-2 OS=Drosophila melanogaster GN=nrv2 PE=1 SV=2 PF00287//PF05011 Sodium / potassium ATPase beta chain//Lariat debranching enzyme, C-terminal domain GO:0006814//GO:0006397//GO:0046034//GO:0006813 sodium ion transport//mRNA processing//ATP metabolic process//potassium ion transport GO:0005391//GO:0016788 sodium:potassium-exchanging ATPase activity//hydrolase activity, acting on ester bonds GO:0005890//GO:0016020 sodium:potassium-exchanging ATPase complex//membrane KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.39829 BF_2 51.29 0.55 4155 91084907 XP_969916.1 3578 0.0e+00 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 392 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2849 0.0e+00 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911//PF00551 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain//Formyl transferase GO:0009058//GO:0055114//GO:0032259//GO:0008152 biosynthetic process//oxidation-reduction process//methylation//metabolic process GO:0016742//GO:0008168//GO:0016620//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//methyltransferase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.39830 BF_2 276.69 3.28 3813 642930595 XP_001807608.2 1817 5.0e-200 PREDICTED: uncharacterized protein LOC100141681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01783//PF03091//PF00240 Ribosomal L32p protein family//CutA1 divalent ion tolerance protein//Ubiquitin family GO:0010038//GO:0006412//GO:0042254 response to metal ion//translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0015934 ribosome//large ribosomal subunit -- -- Cluster-8309.39831 BF_2 61.69 1.01 2848 642927427 XP_008195268.1 1097 1.2e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF16622 Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.39833 BF_2 1098.25 6.41 7453 642914570 XP_008190269.1 2714 9.5e-304 PREDICTED: dnaJ homolog subfamily C member 10-like [Tribolium castaneum] -- -- -- -- -- K09530 DNAJC10 DnaJ homolog subfamily C member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09530 Q5R5L3 1304 1.2e-141 DnaJ homolog subfamily C member 10 OS=Pongo abelii GN=DNAJC10 PE=2 SV=1 PF01216//PF00085//PF08534//PF00071//PF00578 Calsequestrin//Thioredoxin//Redoxin//Ras family//AhpC/TSA family GO:0007264//GO:0045454//GO:0055114 small GTPase mediated signal transduction//cell redox homeostasis//oxidation-reduction process GO:0016491//GO:0005525//GO:0005509//GO:0016209 oxidoreductase activity//GTP binding//calcium ion binding//antioxidant activity -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.39834 BF_2 552.00 5.50 4487 642922942 XP_008200462.1 3059 0.0e+00 PREDICTED: GRIP and coiled-coil domain-containing protein 2 [Tribolium castaneum]>gi|270006579|gb|EFA03027.1| hypothetical protein TcasGA2_TC010451 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 478 4.5e-46 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.39835 BF_2 24.38 1.21 1128 270008800 EFA05248.1 261 4.0e-20 hypothetical protein TcasGA2_TC015399 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39836 BF_2 650.47 4.05 6998 478257467 ENN77623.1 2412 9.3e-269 hypothetical protein YQE_05917, partial [Dendroctonus ponderosae]>gi|546679861|gb|ERL90249.1| hypothetical protein D910_07601 [Dendroctonus ponderosae] 795110653 XM_012026968.1 101 2.28044e-42 PREDICTED: Vollenhovia emeryi alpha-protein kinase 1 (LOC105570040), transcript variant X5, mRNA K01835 pgm phosphoglucomutase http://www.genome.jp/dbget-bin/www_bget?ko:K01835 Q9VUY9 1947 3.2e-216 Phosphoglucomutase OS=Drosophila melanogaster GN=Pgm PE=1 SV=1 PF00408//PF00097//PF16672//PF14634//PF13639//PF00076//PF15965//PF02880//PF02879//PF09726//PF02878 Phosphoglucomutase/phosphomannomutase, C-terminal domain//Zinc finger, C3HC4 type (RING finger)//Ragulator complex protein LAMTOR5//zinc-RING finger domain//Ring finger domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//TRAF-like zinc-finger//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Transmembrane protein//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I GO:0043066//GO:0019079//GO:0071704//GO:0043154//GO:0005975 negative regulation of apoptotic process//viral genome replication//organic substance metabolic process//negative regulation of cysteine-type endopeptidase activity involved in apoptotic process//carbohydrate metabolic process GO:0005515//GO:0046872//GO:0008270//GO:0003676//GO:0016868 protein binding//metal ion binding//zinc ion binding//nucleic acid binding//intramolecular transferase activity, phosphotransferases GO:0016021//GO:0071986//GO:0005737 integral component of membrane//Ragulator complex//cytoplasm KOG0625 Phosphoglucomutase Cluster-8309.39839 BF_2 222.89 1.40 6927 270003642 EFA00090.1 2554 3.2e-285 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.73261e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 702 7.3e-72 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF00536//PF08040//PF07647//PF00595//PF02198//PF13180 SAM domain (Sterile alpha motif)//MNLL subunit//SAM domain (Sterile alpha motif)//PDZ domain (Also known as DHR or GLGF)//Sterile alpha motif (SAM)/Pointed domain//PDZ domain GO:0006118 obsolete electron transport GO:0005515//GO:0003954//GO:0043565 protein binding//NADH dehydrogenase activity//sequence-specific DNA binding GO:0005739//GO:0005634 mitochondrion//nucleus KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.3984 BF_2 16.00 0.38 2047 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.39841 BF_2 97.54 4.63 1169 644996952 XP_008213272.1 724 8.5e-74 PREDICTED: sn1-specific diacylglycerol lipase alpha isoform X3 [Nasonia vitripennis] -- -- -- -- -- K13806 DAGL sn1-specific diacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K13806 Q9Y4D2 427 9.6e-41 Sn1-specific diacylglycerol lipase alpha OS=Homo sapiens GN=DAGLA PE=1 SV=3 PF07168 Ureide permease GO:0071705 nitrogen compound transport -- -- -- -- KOG2088 Predicted lipase/calmodulin-binding heat-shock protein Cluster-8309.39842 BF_2 432.98 1.87 9961 642922507 XP_008193202.1 9553 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.54909e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1766 4.4e-195 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF00632//PF04625//PF00658//PF11547 HECT-domain (ubiquitin-transferase)//DEC-1 protein, N-terminal region//Poly-adenylate binding protein, unique domain//E3 ubiquitin ligase EDD GO:0016567//GO:0007304 protein ubiquitination//chorion-containing eggshell formation GO:0043130//GO:0005213//GO:0003723//GO:0004842 ubiquitin binding//structural constituent of chorion//RNA binding//ubiquitin-protein transferase activity GO:0005576//GO:0042600 extracellular region//chorion KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.39843 BF_2 386.26 1.88 8883 642922507 XP_008193202.1 8545 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.27219e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1766 3.9e-195 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF00658//PF04625//PF11547 Poly-adenylate binding protein, unique domain//DEC-1 protein, N-terminal region//E3 ubiquitin ligase EDD GO:0007304 chorion-containing eggshell formation GO:0003723//GO:0043130//GO:0005213 RNA binding//ubiquitin binding//structural constituent of chorion GO:0005576//GO:0042600 extracellular region//chorion KOG0943 Predicted ubiquitin-protein ligase/hyperplastic discs protein, HECT superfamily Cluster-8309.39844 BF_2 18.29 0.34 2551 642920869 XP_008192593.1 1746 5.7e-192 PREDICTED: protein turtle isoform X8 [Tribolium castaneum] 642920870 XM_008194372.1 138 2.22918e-63 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X14, mRNA -- -- -- -- Q967D7 486 3.0e-47 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39845 BF_2 142.58 0.64 9667 411145887 AFW04603.1 2140 4.5e-237 giwi protein [Gampsocleis gratiosa] 820846169 XM_003692874.2 149 6.54517e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 Q7Z3Z3 1103 3.3e-118 Piwi-like protein 3 OS=Homo sapiens GN=PIWIL3 PE=2 SV=2 PF02230//PF02171//PF04636//PF09494//PF07859//PF01764//PF15384//PF02170//PF02186 Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin)//Slx4 endonuclease//alpha/beta hydrolase fold//Lipase (class 3)//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//PAZ domain//TFIIE beta subunit core domain GO:0008152//GO:0006629//GO:0006303//GO:0006281//GO:0006260//GO:1901031//GO:0006367//GO:0006308 metabolic process//lipid metabolic process//double-strand break repair via nonhomologous end joining//DNA repair//DNA replication//regulation of response to reactive oxygen species//transcription initiation from RNA polymerase II promoter//DNA catabolic process GO:0016787//GO:0017108//GO:0005515//GO:0003676 hydrolase activity//5'-flap endonuclease activity//protein binding//nucleic acid binding GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.39851 BF_2 2015.00 14.98 5914 642914669 XP_008190307.1 3036 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.25905e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39852 BF_2 534.36 4.00 5875 642914671 XP_008190309.1 3005 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.23079e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39853 BF_2 1915.08 87.19 1206 642920923 XP_008192617.1 925 4.3e-97 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 515 6.2e-51 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.39854 BF_2 4283.88 25.02 7450 270014225 EFA10673.1 5723 0.0e+00 muscle-specific protein 300 [Tribolium castaneum] -- -- -- -- -- K19326 SYNE1 nesprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19326 Q6ZWQ0 816 4.8e-85 Nesprin-2 OS=Mus musculus GN=Syne2 PE=1 SV=2 PF00435//PF14554//PF10541 Spectrin repeat//VEGF heparin-binding domain//Nuclear envelope localisation domain -- -- GO:0005515//GO:0008201 protein binding//heparin binding GO:0016021 integral component of membrane -- -- Cluster-8309.39857 BF_2 2223.09 79.02 1464 91086655 XP_967836.1 1659 4.0e-182 PREDICTED: minor histocompatibility antigen H13 [Tribolium castaneum]>gi|270010389|gb|EFA06837.1| hypothetical protein TcasGA2_TC009780 [Tribolium castaneum] -- -- -- -- -- K09595 HM13 minor histocompatibility antigen H13 http://www.genome.jp/dbget-bin/www_bget?ko:K09595 Q8TCT9 1170 8.4e-127 Minor histocompatibility antigen H13 OS=Homo sapiens GN=HM13 PE=1 SV=1 PF01080//PF04258 Presenilin//Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.39858 BF_2 740.32 117.35 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39861 BF_2 498.38 17.25 1496 546682404 ERL92346.1 568 1.3e-55 hypothetical protein D910_09663 [Dendroctonus ponderosae] -- -- -- -- -- K06832 LGALS8 galectin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K06832 O00214 248 7.0e-20 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.39862 BF_2 586.62 14.80 1945 546682404 ERL92346.1 668 4.4e-67 hypothetical protein D910_09663 [Dendroctonus ponderosae] -- -- -- -- -- K06832 LGALS8 galectin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K06832 O00214 248 9.1e-20 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.39864 BF_2 72.80 1.54 2267 817056987 XP_012269382.1 1267 1.8e-136 PREDICTED: casein kinase I isoform alpha isoform X4 [Athalia rosae] 657560379 XM_008285733.1 238 5.08668e-119 PREDICTED: Stegastes partitus casein kinase 1, delta (csnk1d), mRNA K08960 CSNK1E casein kinase 1, epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K08960 Q5ZLL1 1211 2.3e-131 Casein kinase I isoform epsilon OS=Gallus gallus GN=CSNK1E PE=2 SV=2 PF00069//PF07714//PF05445 Protein kinase domain//Protein tyrosine kinase//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.39867 BF_2 1520.00 23.24 3023 478249890 ENN70397.1 973 2.9e-102 hypothetical protein YQE_12903, partial [Dendroctonus ponderosae]>gi|546683396|gb|ERL93215.1| hypothetical protein D910_10511 [Dendroctonus ponderosae] 507621445 XM_004625352.1 143 4.3959e-66 PREDICTED: Octodon degus ADP-ribosylation factor-like 8A (Arl8a), transcript variant X1, mRNA K07955 ARL8 ADP-ribosylation factor-like protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K07955 Q9NVJ2 895 1.3e-94 ADP-ribosylation factor-like protein 8B OS=Homo sapiens GN=ARL8B PE=1 SV=1 PF00503//PF04670//PF00025//PF00071//PF08477//PF01926 G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0005525//GO:0004871//GO:0019001//GO:0031683//GO:0003924 GTP binding//signal transducer activity//guanyl nucleotide binding//G-protein beta/gamma-subunit complex binding//GTPase activity -- -- KOG0075 GTP-binding ADP-ribosylation factor-like protein Cluster-8309.39868 BF_2 19.71 6.26 418 642928567 XP_008199961.1 407 1.7e-37 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 O18635 256 2.3e-21 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.39869 BF_2 69.75 0.45 6730 642915750 XP_008190789.1 4165 0.0e+00 PREDICTED: band 3 anion transport protein isoform X2 [Tribolium castaneum] 805826292 XM_012297626.1 59 4.88247e-19 PREDICTED: Megachile rotundata band 3 anion transport protein (LOC100874797), transcript variant X6, mRNA K13856 SLC4A3, AE3 solute carrier family 4 (anion exchanger), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13856 P23348 2087 1.8e-232 Anion exchange protein 3 OS=Rattus norvegicus GN=Slc4a3 PE=2 SV=1 PF07565//PF00955 Band 3 cytoplasmic domain//HCO3- transporter family GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.39870 BF_2 108.38 0.90 5314 642919913 XP_008192122.1 1315 1.1e-141 PREDICTED: transcription factor SOX-13 [Tribolium castaneum] 759081689 XM_011352406.1 129 4.70803e-58 PREDICTED: Cerapachys biroi transcription factor SOX-5 (LOC105287028), mRNA K09269 SOX5_6_13 transcription factor SOX5/6/13 (SOX group D) http://www.genome.jp/dbget-bin/www_bget?ko:K09269 P35712 523 3.2e-51 Transcription factor SOX-6 OS=Homo sapiens GN=SOX6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0528 HMG-box transcription factor SOX5 Cluster-8309.39871 BF_2 56.39 0.32 7577 91088789 XP_968000.1 1311 4.7e-141 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02833 361 2.8e-32 Insulin-like growth factor-binding protein complex acid labile subunit OS=Papio hamadryas GN=IGFALS PE=2 SV=1 PF00560//PF02805//PF13855 Leucine Rich Repeat//Metal binding domain of Ada//Leucine rich repeat GO:0006355//GO:0006281 regulation of transcription, DNA-templated//DNA repair GO:0003677//GO:0008168//GO:0008270//GO:0005515 DNA binding//methyltransferase activity//zinc ion binding//protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.39872 BF_2 59.51 0.76 3560 91088789 XP_968000.1 859 5.7e-89 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35859 291 1.7e-24 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF00560//PF01943//PF13855 Leucine Rich Repeat//Polysaccharide biosynthesis protein//Leucine rich repeat GO:0000271 polysaccharide biosynthetic process GO:0005515 protein binding GO:0016020 membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.39873 BF_2 1036.00 12.80 3673 91092728 XP_972902.1 2508 3.6e-280 PREDICTED: GTP-binding protein 2 [Tribolium castaneum]>gi|270014879|gb|EFA11327.1| hypothetical protein TcasGA2_TC010866 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BX10 1442 6.1e-158 GTP-binding protein 2 OS=Homo sapiens GN=GTPBP2 PE=1 SV=1 PF03144//PF03193//PF00005//PF01926//PF05676//PF10662//PF00025 Elongation factor Tu domain 2//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Ethanolamine utilisation - propanediol utilisation//ADP-ribosylation factor family GO:0006184//GO:0006744//GO:0006118//GO:0006814//GO:0015992//GO:0006120//GO:0006576 obsolete GTP catabolic process//ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//proton transport//mitochondrial electron transport, NADH to ubiquinone//cellular biogenic amine metabolic process GO:0016887//GO:0005525//GO:0008137//GO:0005524//GO:0003954//GO:0003924 ATPase activity//GTP binding//NADH dehydrogenase (ubiquinone) activity//ATP binding//NADH dehydrogenase activity//GTPase activity GO:0005739 mitochondrion KOG1143 Predicted translation elongation factor Cluster-8309.39874 BF_2 930.16 22.90 1986 91094127 XP_968492.1 2115 7.3e-235 PREDICTED: probable aminopeptidase NPEPL1 [Tribolium castaneum]>gi|270010872|gb|EFA07320.1| hypothetical protein TcasGA2_TC015913 [Tribolium castaneum] -- -- -- -- -- K09611 NPEPL1 probable aminopeptidase NPEPL1 http://www.genome.jp/dbget-bin/www_bget?ko:K09611 Q5R7G6 1606 3.1e-177 Probable aminopeptidase NPEPL1 OS=Pongo abelii GN=NPEPL1 PE=3 SV=2 PF00883 Cytosol aminopeptidase family, catalytic domain GO:0006508 proteolysis GO:0030145//GO:0004177//GO:0008235 manganese ion binding//aminopeptidase activity//metalloexopeptidase activity GO:0005737//GO:0005622 cytoplasm//intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.39876 BF_2 3.00 1.96 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39877 BF_2 10.79 0.55 1106 332374316 AEE62299.1 608 2.3e-60 unknown [Dendroctonus ponderosae]>gi|478255157|gb|ENN75386.1| hypothetical protein YQE_07938, partial [Dendroctonus ponderosae]>gi|546677194|gb|ERL88076.1| hypothetical protein D910_05465 [Dendroctonus ponderosae] 662192887 XM_008471100.1 80 1.65877e-31 PREDICTED: Diaphorina citri cytochrome c-type heme lyase (LOC103506705), mRNA K01764 E4.4.1.17 cytochrome c heme-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01764 P53702 408 1.4e-38 Cytochrome c-type heme lyase OS=Mus musculus GN=Hccs PE=1 SV=2 PF01265 Cytochrome c/c1 heme lyase GO:0015994 chlorophyll metabolic process GO:0004408 holocytochrome-c synthase activity GO:0005739 mitochondrion KOG3996 Holocytochrome c synthase/heme-lyase Cluster-8309.39880 BF_2 958.12 5.50 7575 91092074 XP_971115.1 1545 3.5e-168 PREDICTED: uncharacterized protein LOC659745 [Tribolium castaneum]>gi|270004682|gb|EFA01130.1| hypothetical protein TcasGA2_TC010343 [Tribolium castaneum] 642917993 XM_966022.2 241 3.69005e-120 PREDICTED: Tribolium castaneum uncharacterized LOC659745 (LOC659745), mRNA K10480 BTBD8 BTB/POZ domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10480 Q5XKL5 240 3.0e-18 BTB/POZ domain-containing protein 8 OS=Homo sapiens GN=BTBD8 PE=2 SV=2 PF07267//PF00651//PF07271//PF15952//PF02517//PF05757 Nucleopolyhedrovirus capsid protein P87//BTB/POZ domain//Cytadhesin P30/P32//Enhancer of split M4 family//CAAX protease self-immunity//Oxygen evolving enhancer protein 3 (PsbQ) GO:0007157//GO:0007423//GO:0015979//GO:0007219//GO:0009405 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules//sensory organ development//photosynthesis//Notch signaling pathway//pathogenesis GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0009523//GO:0016020//GO:0009654//GO:0019898//GO:0016021//GO:0019028 photosystem II//membrane//photosystem II oxygen evolving complex//extrinsic component of membrane//integral component of membrane//viral capsid -- -- Cluster-8309.39882 BF_2 217.69 1.29 7326 642930494 XP_008196427.1 2252 3.5e-250 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 A1A5G0 910 5.9e-96 CLIP-associating protein 1 OS=Xenopus tropicalis GN=clasp1 PE=1 SV=1 PF02985//PF01602//PF01528 HEAT repeat//Adaptin N terminal region//Herpesvirus glycoprotein M GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0030117 membrane//membrane coat -- -- Cluster-8309.39883 BF_2 95.43 0.59 7107 642930494 XP_008196427.1 2984 0.0e+00 PREDICTED: CLIP-associating protein isoform X2 [Tribolium castaneum]>gi|270009386|gb|EFA05834.1| hypothetical protein TcasGA2_TC008618 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 928 4.7e-98 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF01528//PF12844//PF11640//PF02985 Herpesvirus glycoprotein M//Helix-turn-helix domain//Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0004674//GO:0043565 protein binding//protein serine/threonine kinase activity//sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.39884 BF_2 178.69 27.59 558 478255706 ENN75917.1 453 1.1e-42 hypothetical protein YQE_07558, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39887 BF_2 175.68 0.97 7856 649572303 NP_001280516.1 1401 1.8e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.64749e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.5e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF01602//PF11698//PF02778//PF00514//PF02297//PF02985//PF01974 Adaptin N terminal region//V-ATPase subunit H//tRNA intron endonuclease, N-terminal domain//Armadillo/beta-catenin-like repeat//Cytochrome oxidase c subunit VIb//HEAT repeat//tRNA intron endonuclease, catalytic C-terminal domain GO:0006123//GO:0006886//GO:0016192//GO:0015992//GO:0051252//GO:0006388//GO:0006119//GO:0015991 mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//vesicle-mediated transport//proton transport//regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961//GO:0000213//GO:0016820//GO:0005515//GO:0004129 proton-transporting ATPase activity, rotational mechanism//tRNA-intron endonuclease activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//cytochrome-c oxidase activity GO:0005739//GO:0000221//GO:0045277//GO:0000214//GO:0030117 mitochondrion//vacuolar proton-transporting V-type ATPase, V1 domain//respiratory chain complex IV//tRNA-intron endonuclease complex//membrane coat KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.39888 BF_2 80.82 1.67 2310 642915291 XP_008190557.1 1285 1.5e-138 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 605 4.3e-61 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.39889 BF_2 29.54 0.50 2755 642915291 XP_008190557.1 1180 2.7e-126 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8VI02 565 2.2e-56 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Rattus norvegicus GN=Ppp4r1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.39891 BF_2 1019.80 31.01 1663 642915291 XP_008190557.1 1102 1.8e-117 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8TF05 768 3.9e-80 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Homo sapiens GN=PPP4R1 PE=1 SV=1 PF00311//PF01602//PF02985//PF10410 Phosphoenolpyruvate carboxylase//Adaptin N terminal region//HEAT repeat//DnaB-helicase binding domain of primase GO:0006099//GO:0006094//GO:0015977//GO:0019643//GO:0016192//GO:0006886 tricarboxylic acid cycle//gluconeogenesis//carbon fixation//reductive tricarboxylic acid cycle//vesicle-mediated transport//intracellular protein transport GO:0016779//GO:0008964//GO:0005515 nucleotidyltransferase activity//phosphoenolpyruvate carboxylase activity//protein binding GO:0030117 membrane coat -- -- Cluster-8309.39893 BF_2 198.88 2.22 4037 91079776 XP_967502.1 1323 1.0e-142 PREDICTED: coiled-coil domain-containing protein 50 [Tribolium castaneum]>gi|270004516|gb|EFA00964.1| hypothetical protein TcasGA2_TC003874 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IVM0 183 6.5e-12 Coiled-coil domain-containing protein 50 OS=Homo sapiens GN=CCDC50 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39894 BF_2 1732.03 24.55 3238 189241130 XP_973380.2 3292 0.0e+00 PREDICTED: melanotransferrin [Tribolium castaneum]>gi|270013329|gb|EFA09777.1| hypothetical protein TcasGA2_TC011919 [Tribolium castaneum] -- -- -- -- -- K06569 MFI2 melanoma-associated antigen p97 http://www.genome.jp/dbget-bin/www_bget?ko:K06569 O97490 629 1.0e-63 Melanotransferrin OS=Oryctolagus cuniculus GN=Mfi2 PE=2 SV=1 PF00172 Fungal Zn(2)-Cys(6) binuclear cluster domain GO:0006355//GO:0044699 regulation of transcription, DNA-templated//single-organism process GO:0008270//GO:0000981 zinc ion binding//RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.39897 BF_2 59.68 0.59 4547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39899 BF_2 515.49 6.30 3711 270013391 EFA09839.1 785 2.3e-80 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 194893319 XM_001977817.1 90 1.56894e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- P08897 240 1.5e-18 Collagenase OS=Hypoderma lineatum PE=1 SV=3 PF00008//PF00089//PF06373 EGF-like domain//Trypsin//Cocaine and amphetamine regulated transcript protein (CART) GO:0009267//GO:0000186//GO:0007186//GO:0006508//GO:0001678//GO:0008343//GO:0032099 cellular response to starvation//activation of MAPKK activity//G-protein coupled receptor signaling pathway//proteolysis//cellular glucose homeostasis//adult feeding behavior//negative regulation of appetite GO:0004252//GO:0005515 serine-type endopeptidase activity//protein binding GO:0005615 extracellular space -- -- Cluster-8309.39901 BF_2 1295.47 59.56 1197 403234001 AFR31785.1 666 4.6e-67 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P08836 199 2.7e-14 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.39902 BF_2 3508.24 68.81 2420 91076170 XP_971503.1 2162 3.1e-240 PREDICTED: synaptic vesicle glycoprotein 2B [Tribolium castaneum]>gi|270014563|gb|EFA11011.1| hypothetical protein TcasGA2_TC004597 [Tribolium castaneum] 91076169 XM_966410.1 401 0 PREDICTED: Tribolium castaneum synaptic vesicle glycoprotein 2B (LOC660155), mRNA K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q8BG39 503 3.1e-49 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.39903 BF_2 816.74 32.18 1349 91085965 XP_971530.1 888 9.4e-93 PREDICTED: protein ERGIC-53 [Tribolium castaneum]>gi|270010174|gb|EFA06622.1| hypothetical protein TcasGA2_TC009540 [Tribolium castaneum] -- -- -- -- -- K10080 LMAN1, ERGIC53 lectin, mannose-binding 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10080 Q9TU32 266 5.2e-22 Protein ERGIC-53 OS=Chlorocebus aethiops GN=LMAN1 PE=2 SV=1 PF17001//PF08649//PF06008//PF01442//PF00657//PF00621//PF16740//PF06320 Type III secretion basal body protein I, YscI, HrpB, PscI//DASH complex subunit Dad1//Laminin Domain I//Apolipoprotein A1/A4/E domain//GDSL-like Lipase/Acylhydrolase//RhoGEF domain//Spindle and kinetochore-associated protein 2//GCN5-like protein 1 (GCN5L1) GO:0043087//GO:0030155//GO:0030472//GO:0042157//GO:0006869//GO:0051301//GO:0031110//GO:0000090//GO:0007067//GO:0007059//GO:0045995//GO:0035023//GO:0007165//GO:0030334//GO:0009306 regulation of GTPase activity//regulation of cell adhesion//mitotic spindle organization in nucleus//lipoprotein metabolic process//lipid transport//cell division//regulation of microtubule polymerization or depolymerization//mitotic anaphase//mitotic nuclear division//chromosome segregation//regulation of embryonic development//regulation of Rho protein signal transduction//signal transduction//regulation of cell migration//protein secretion GO:0008017//GO:0005089//GO:0008289//GO:0016788//GO:0005102 microtubule binding//Rho guanyl-nucleotide exchange factor activity//lipid binding//hydrolase activity, acting on ester bonds//receptor binding GO:0016020//GO:0000940//GO:0005576//GO:0031083//GO:0072686//GO:0042729//GO:0005876//GO:0045298 membrane//condensed chromosome outer kinetochore//extracellular region//BLOC-1 complex//mitotic spindle//DASH complex//spindle microtubule//tubulin complex -- -- Cluster-8309.39905 BF_2 22.26 0.35 2973 270002756 EEZ99203.1 869 3.3e-90 serine protease P8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 611 1.1e-61 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39907 BF_2 1128.47 59.24 1084 -- -- -- -- -- 642913273 XM_008203244.1 72 4.54943e-27 PREDICTED: Tribolium castaneum troponin T, skeletal muscle (LOC663893), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39909 BF_2 52.47 1.54 1716 642917061 XP_008191104.1 1831 5.4e-202 PREDICTED: roundabout homolog 2 [Tribolium castaneum] 642917060 XM_008192882.1 305 2.17878e-156 PREDICTED: Tribolium castaneum roundabout (LOC655427), mRNA K06754 ROBO2 roundabout, axon guidance receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06754 Q9HCK4 1014 1.2e-108 Roundabout homolog 2 OS=Homo sapiens GN=ROBO2 PE=1 SV=2 PF13895//PF08534 Immunoglobulin domain//Redoxin -- -- GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.39911 BF_2 10.63 1.51 582 546681162 ERL91306.1 399 2.0e-36 hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39912 BF_2 218.59 1.52 6294 642926894 XP_008195055.1 6729 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] 642926897 XM_008196835.1 383 0 PREDICTED: Tribolium castaneum ATP-binding cassette sub-family A member 5-like (LOC661331), transcript variant X3, mRNA K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 1257 2.9e-136 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 PF00448//PF03193//PF00005//PF02367//PF01926//PF13304 SRP54-type protein, GTPase domain//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006200//GO:0006614//GO:0002949 obsolete ATP catabolic process//SRP-dependent cotranslational protein targeting to membrane//tRNA threonylcarbamoyladenosine modification GO:0003924//GO:0005525//GO:0005524//GO:0016887 GTPase activity//GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.39913 BF_2 130.54 1.00 5760 642918509 XP_008191502.1 6566 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 1 [Tribolium castaneum]>gi|270003219|gb|EEZ99666.1| hypothetical protein TcasGA2_TC002423 [Tribolium castaneum] 585685897 XM_006820162.1 113 4.00332e-49 PREDICTED: Saccoglossus kowalevskii brefeldin A-inhibited guanine nucleotide-exchange protein 1-like (LOC100366823), mRNA K18442 ARFGEF, BIG brefeldin A-inhibited guanine nucleotide-exchange protein http://www.genome.jp/dbget-bin/www_bget?ko:K18442 Q9Y6D5 4863 0.0e+00 Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Homo sapiens GN=ARFGEF2 PE=1 SV=3 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity GO:0005622 intracellular KOG0929 Guanine nucleotide exchange factor Cluster-8309.39917 BF_2 16.00 0.54 1531 642912421 XP_008193352.1 714 1.6e-72 PREDICTED: serine protease snake-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 491 4.8e-48 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.39920 BF_2 234.55 1.02 9892 270003134 EEZ99581.1 841 1.9e-86 hypothetical protein TcasGA2_TC001567 [Tribolium castaneum] 641653063 XM_003241514.2 58 2.58567e-18 PREDICTED: Acyrthosiphon pisum zinc finger protein ubi-d4 (LOC100161288), transcript variant X3, mRNA K13196 DPF2, REQ zinc finger protein ubi-d4 http://www.genome.jp/dbget-bin/www_bget?ko:K13196 Q9W636 381 1.7e-34 Zinc finger protein ubi-d4 B (Fragment) OS=Xenopus laevis GN=req-b PE=2 SV=2 PF00684//PF00628//PF02064 DnaJ central domain//PHD-finger//MAS20 protein import receptor GO:0006886//GO:0006605 intracellular protein transport//protein targeting GO:0005515//GO:0031072//GO:0051082 protein binding//heat shock protein binding//unfolded protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1244 Predicted transcription factor Requiem/NEURO-D4 Cluster-8309.39921 BF_2 169.52 0.46 15597 270010181 EFA06629.1 16316 0.0e+00 hypothetical protein TcasGA2_TC009548 [Tribolium castaneum] -- -- -- -- -- K04550 LRP1, CD91 low-density lipoprotein receptor-related protein 1 (alpha-2-macroglobulin receptor) http://www.genome.jp/dbget-bin/www_bget?ko:K04550 P98157 8292 0.0e+00 Low-density lipoprotein receptor-related protein 1 OS=Gallus gallus GN=LRP1 PE=2 SV=1 PF09008//PF07645//PF00008//PF00057//PF06769//PF02022 Head binding//Calcium-binding EGF domain//EGF-like domain//Low-density lipoprotein receptor domain class A//YoeB-like toxin of bacterial type II toxin-antitoxin system//Integrase Zinc binding domain GO:0006401//GO:0009405 RNA catabolic process//pathogenesis GO:0008270//GO:0004519//GO:0005509//GO:0005515 zinc ion binding//endonuclease activity//calcium ion binding//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.39922 BF_2 2083.17 29.07 3285 642912959 XP_008201326.1 2898 0.0e+00 PREDICTED: programmed cell death 6-interacting protein [Tribolium castaneum]>gi|270001905|gb|EEZ98352.1| hypothetical protein TcasGA2_TC000807 [Tribolium castaneum] -- -- -- -- -- K12200 PDCD6IP, ALIX, RIM20 programmed cell death 6-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12200 Q9W6C5 1523 2.2e-167 Programmed cell death 6-interacting protein OS=Xenopus laevis GN=pdcd6ip PE=1 SV=1 PF13949//PF17082//PF04111 ALIX V-shaped domain binding to HIV//Spindle Pole Component 29//Autophagy protein Apg6 GO:0006914//GO:0030474 autophagy//spindle pole body duplication GO:0005515//GO:0005200 protein binding//structural constituent of cytoskeleton GO:0005856//GO:0005823 cytoskeleton//central plaque of spindle pole body KOG2220 Predicted signal transduction protein Cluster-8309.39924 BF_2 78.08 0.53 6399 91089853 XP_970874.1 1673 4.2e-183 PREDICTED: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [Tribolium castaneum]>gi|270013647|gb|EFA10095.1| hypothetical protein TcasGA2_TC012273 [Tribolium castaneum] 817186518 XM_012432341.1 237 5.21144e-118 PREDICTED: Orussus abietinus protein phosphatase PP2A 55 kDa regulatory subunit (LOC105703734), transcript variant X6, mRNA K04354 PPP2R2 serine/threonine-protein phosphatase 2A regulatory subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K04354 P36872 1427 5.8e-156 Protein phosphatase PP2A 55 kDa regulatory subunit OS=Drosophila melanogaster GN=tws PE=2 SV=1 PF00400//PF11093//PF13463//PF13465 WD domain, G-beta repeat//Mitochondrial export protein Som1//Winged helix DNA-binding domain//Zinc-finger double domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0046872//GO:0003700//GO:0008601//GO:0005515 metal ion binding//transcription factor activity, sequence-specific DNA binding//protein phosphatase type 2A regulator activity//protein binding GO:0000159//GO:0042720//GO:0005667 protein phosphatase type 2A complex//mitochondrial inner membrane peptidase complex//transcription factor complex KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.39925 BF_2 217.42 2.80 3535 91076520 XP_973486.1 895 3.8e-93 PREDICTED: leucine-rich repeat-containing protein 57 [Tribolium castaneum]>gi|270002609|gb|EEZ99056.1| hypothetical protein TcasGA2_TC004931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INV3 588 6.2e-59 Leucine-rich repeat-containing protein 57 OS=Xenopus laevis GN=lrrc57 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.39926 BF_2 1960.46 13.69 6279 642912571 XP_008200914.1 1898 3.4e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.13857e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.3e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF03425//PF03278//PF00617 Carbohydrate binding domain (family 11)//IpaB/EvcA family//RasGEF domain GO:0043087//GO:0007264//GO:0030245//GO:0005982//GO:0009405//GO:0005985 regulation of GTPase activity//small GTPase mediated signal transduction//cellulose catabolic process//starch metabolic process//pathogenesis//sucrose metabolic process GO:0008810//GO:0005085 cellulase activity//guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.39927 BF_2 57.12 0.90 2952 122064577 P81926.2 336 2.1e-28 RecName: Full=Superoxide dismutase [Cu-Zn] [Halocynthia roretzi] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P81926 336 8.6e-30 Superoxide dismutase [Cu-Zn] OS=Halocynthia roretzi PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.39930 BF_2 22.09 0.40 2616 728416984 AIY68330.1 1246 5.6e-134 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 618 1.5e-62 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.39932 BF_2 1562.25 30.66 2419 91086561 XP_975997.1 1036 1.2e-109 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X1 [Tribolium castaneum]>gi|270009775|gb|EFA06223.1| hypothetical protein TcasGA2_TC009072 [Tribolium castaneum] 766927493 XM_011497449.1 59 1.7402e-19 PREDICTED: Ceratosolen solmsi marchali phosphoenolpyruvate carboxykinase [GTP]-like (LOC105360529), mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 934 3.2e-99 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006099//GO:0006094 tricarboxylic acid cycle//gluconeogenesis GO:0005525//GO:0004611//GO:0004613 GTP binding//phosphoenolpyruvate carboxykinase activity//phosphoenolpyruvate carboxykinase (GTP) activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.39934 BF_2 779.82 7.05 4913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02258//PF03798 Shiga-like toxin beta subunit//TLC domain GO:0019836 hemolysis by symbiont of host erythrocytes -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.39938 BF_2 179.28 4.99 1790 820858959 XP_012346450.1 487 3.9e-46 PREDICTED: uncharacterized protein LOC100869561 [Apis florea] 645008120 XM_003425686.2 127 2.02571e-57 PREDICTED: Nasonia vitripennis uncharacterized LOC100121483 (LOC100121483), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF03896//PF06459//PF03522//PF02862//PF07168//PF13965//PF00856//PF12326//PF03286//PF03348//PF05529//PF16965 Translocon-associated protein (TRAP), alpha subunit//Ryanodine Receptor TM 4-6//Solute carrier family 12//DDHD domain//Ureide permease//dsRNA-gated channel SID-1//SET domain//N-glycosylation protein//Pox virus Ag35 surface protein//Serine incorporator (Serinc)//B-cell receptor-associated protein 31-like//Ceramide synthase regulator GO:0071705//GO:0034599//GO:0006811//GO:0006816//GO:0015931//GO:0006886//GO:0006810//GO:0033227//GO:0006874 nitrogen compound transport//cellular response to oxidative stress//ion transport//calcium ion transport//nucleobase-containing compound transport//intracellular protein transport//transport//dsRNA transport//cellular calcium ion homeostasis GO:0005219//GO:0005515//GO:0005215//GO:0051033//GO:0046872//GO:0030234 ryanodine-sensitive calcium-release channel activity//protein binding//transporter activity//RNA transmembrane transporter activity//metal ion binding//enzyme regulator activity GO:0030176//GO:0005789//GO:0019031//GO:0005783//GO:0016020//GO:0016021//GO:0005622 integral component of endoplasmic reticulum membrane//endoplasmic reticulum membrane//viral envelope//endoplasmic reticulum//membrane//integral component of membrane//intracellular -- -- Cluster-8309.39939 BF_2 82.50 2.24 1830 642921007 XP_008192651.1 345 1.2e-29 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 645008130 XM_001605044.3 115 9.70795e-51 PREDICTED: Nasonia vitripennis uncharacterized LOC100121483 (LOC100121483), transcript variant X11, mRNA -- -- -- -- -- -- -- -- PF02862//PF02724//PF07168//PF03896//PF03522//PF06459//PF00856//PF12326//PF13965//PF03348//PF03286//PF05529//PF16965//PF05132//PF05238 DDHD domain//CDC45-like protein//Ureide permease//Translocon-associated protein (TRAP), alpha subunit//Solute carrier family 12//Ryanodine Receptor TM 4-6//SET domain//N-glycosylation protein//dsRNA-gated channel SID-1//Serine incorporator (Serinc)//Pox virus Ag35 surface protein//B-cell receptor-associated protein 31-like//Ceramide synthase regulator//RNA polymerase III RPC4//Kinetochore protein CHL4 like GO:0006816//GO:0006886//GO:0006810//GO:0006874//GO:0033227//GO:0007059//GO:0071705//GO:0006351//GO:0006144//GO:0006206//GO:0034599//GO:0006811//GO:0015931//GO:0034508//GO:0006270//GO:0006383 calcium ion transport//intracellular protein transport//transport//cellular calcium ion homeostasis//dsRNA transport//chromosome segregation//nitrogen compound transport//transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//cellular response to oxidative stress//ion transport//nucleobase-containing compound transport//centromere complex assembly//DNA replication initiation//transcription from RNA polymerase III promoter GO:0003899//GO:0003677//GO:0005219//GO:0005515//GO:0051033//GO:0030234//GO:0005215//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding//RNA transmembrane transporter activity//enzyme regulator activity//transporter activity//metal ion binding GO:0016021//GO:0005622//GO:0005789//GO:0019031//GO:0005783//GO:0016020//GO:0005666//GO:0005730//GO:0030176 integral component of membrane//intracellular//endoplasmic reticulum membrane//viral envelope//endoplasmic reticulum//membrane//DNA-directed RNA polymerase III complex//nucleolus//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.39940 BF_2 117.67 4.18 1464 642921007 XP_008192651.1 1453 3.1e-158 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 5.84904e-67 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7M734 135 8.7e-07 Otopetrin-1 OS=Rattus norvegicus GN=Otop1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39942 BF_2 878.22 5.66 6774 642921007 XP_008192651.1 2135 1.2e-236 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 2.75579e-66 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7RTS6 149 9.6e-08 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF01499 Herpesvirus UL25 family GO:0019072 viral genome packaging -- -- GO:0042025 host cell nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.39943 BF_2 655.94 3.46 8220 649572303 NP_001280516.1 1401 1.9e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.72418e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.8e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF01602//PF00514//PF10723//PF02778//PF02297//PF11698//PF01974//PF00600//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//Replication regulatory protein RepB//tRNA intron endonuclease, N-terminal domain//Cytochrome oxidase c subunit VIb//V-ATPase subunit H//tRNA intron endonuclease, catalytic C-terminal domain//Influenza non-structural protein (NS1)//HEAT repeat GO:0006388//GO:0015991//GO:0006119//GO:0051252//GO:0015992//GO:0006276//GO:0006123//GO:0006886//GO:0016192 tRNA splicing, via endonucleolytic cleavage and ligation//ATP hydrolysis coupled proton transport//oxidative phosphorylation//regulation of RNA metabolic process//proton transport//plasmid maintenance//mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//vesicle-mediated transport GO:0004129//GO:0003723//GO:0016820//GO:0005515//GO:0000213//GO:0046961 cytochrome-c oxidase activity//RNA binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//tRNA-intron endonuclease activity//proton-transporting ATPase activity, rotational mechanism GO:0000214//GO:0030117//GO:0045277//GO:0000221//GO:0005739 tRNA-intron endonuclease complex//membrane coat//respiratory chain complex IV//vacuolar proton-transporting V-type ATPase, V1 domain//mitochondrion KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.39944 BF_2 3934.13 10.04 16672 270010741 EFA07189.1 5418 0.0e+00 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] 407731599 JQ771517.1 1610 0 Megacyllene robiniae Na+,K+ ATPase alpha-subunit 1 mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4679 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00014//PF05986//PF02714//PF13895//PF00122//PF04545//PF08686 Kunitz/Bovine pancreatic trypsin inhibitor domain//ADAM-TS Spacer 1//Calcium-dependent channel, 7TM region, putative phosphate//Immunoglobulin domain//E1-E2 ATPase//Sigma-70, region 4//PLAC (protease and lacunin) domain GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0005515//GO:0004867//GO:0003677//GO:0004222//GO:0046872//GO:0003700//GO:0008233//GO:0016987//GO:0000166 protein binding//serine-type endopeptidase inhibitor activity//DNA binding//metalloendopeptidase activity//metal ion binding//transcription factor activity, sequence-specific DNA binding//peptidase activity//sigma factor activity//nucleotide binding GO:0005667//GO:0031012//GO:0016020 transcription factor complex//extracellular matrix//membrane KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.39945 BF_2 203.00 21.40 684 226968615 YP_002808564.1 944 1.5e-99 cytochrome c oxidase subunit II [Scylla paramamosain]>gi|225697851|gb|ACO07218.1| cytochrome c oxidase subunit II [Scylla paramamosain]>gi|403311090|gb|AFR34049.1| cytochrome c oxidase subunit II (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 684 0 Scylla paramamosain mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P98021 748 3.4e-78 Cytochrome c oxidase subunit 2 OS=Simulium vittatum GN=COII PE=3 SV=1 -- -- GO:0015992//GO:0006118//GO:0006123//GO:0022904 proton transport//obsolete electron transport//mitochondrial electron transport, cytochrome c to oxygen//respiratory electron transport chain GO:0004129//GO:0020037//GO:0009055//GO:0005507 cytochrome-c oxidase activity//heme binding//electron carrier activity//copper ion binding GO:0045277//GO:0070469//GO:0016021//GO:0005743 respiratory chain complex IV//respiratory chain//integral component of membrane//mitochondrial inner membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.39947 BF_2 36.24 55.24 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39949 BF_2 965.34 10.35 4187 189239223 XP_973572.2 678 6.5e-68 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 7.79138e-75 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39950 BF_2 31.48 0.74 2078 270016569 EFA13015.1 377 2.6e-33 hypothetical protein TcasGA2_TC001981 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q98931 200 3.6e-14 Low-density lipoprotein receptor-related protein 8 OS=Gallus gallus GN=LRP8 PE=1 SV=1 PF07095//PF06769//PF06682 Intracellular growth attenuator protein IgaA//YoeB-like toxin of bacterial type II toxin-antitoxin system//SOCE-associated regulatory factor of calcium homoeostasis GO:0006401//GO:2001256 RNA catabolic process//regulation of store-operated calcium entry GO:0004519 endonuclease activity GO:0030176//GO:0009276//GO:0016021 integral component of endoplasmic reticulum membrane//Gram-negative-bacterium-type cell wall//integral component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.39951 BF_2 1864.50 21.77 3870 546680769 ERL90975.1 1094 3.5e-116 hypothetical protein D910_08317 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 254 3.6e-20 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39952 BF_2 199.12 4.96 1968 642930669 XP_008199217.1 327 1.5e-27 PREDICTED: uncharacterized protein LOC657834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06206 CpeT/CpcT family (DUF1001) GO:0017009 protein-phycocyanobilin linkage -- -- -- -- -- -- Cluster-8309.39954 BF_2 142.69 0.58 10493 642927134 XP_008195152.1 1690 7.4e-185 PREDICTED: far upstream element-binding protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13210 FUBP far upstream element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13210 Q99PF5 578 2.7e-57 Far upstream element-binding protein 2 OS=Rattus norvegicus GN=Khsrp PE=1 SV=1 PF07650//PF10192//PF13184//PF13014//PF00013 KH domain//Rhodopsin-like GPCR transmembrane domain//NusA-like KH domain//KH domain//KH domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0003723 RNA binding -- -- KOG1676 K-homology type RNA binding proteins Cluster-8309.39955 BF_2 116.65 5.46 1181 478255719 ENN75928.1 584 1.5e-57 hypothetical protein YQE_07465, partial [Dendroctonus ponderosae]>gi|546681163|gb|ERL91307.1| hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35501 129 3.5e-06 Esterase E4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39956 BF_2 2120.36 24.80 3864 270012348 EFA08796.1 798 7.4e-82 hypothetical protein TcasGA2_TC006490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CZ0 327 1.2e-28 UPF0472 protein C16orf72 OS=Homo sapiens GN=C16orf72 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.39959 BF_2 623.55 8.61 3315 642923287 XP_008193691.1 2430 3.6e-271 PREDICTED: venom dipeptidyl peptidase 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B1A4F7 1320 7.7e-144 Venom dipeptidyl peptidase 4 OS=Vespula vulgaris PE=1 SV=1 PF00326//PF00930//PF02129 Prolyl oligopeptidase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family) GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.39961 BF_2 254.12 1.57 7070 91078242 XP_970298.1 3331 0.0e+00 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 642939064 XM_008201985.1 402 0 PREDICTED: Tribolium castaneum xenotropic and polytropic retrovirus receptor 1 (LOC100142189), transcript variant X2, mRNA -- -- -- -- Q9UBH6 1815 6.5e-201 Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens GN=XPR1 PE=1 SV=1 PF00118//PF03124//PF01504 TCP-1/cpn60 chaperonin family//EXS family//Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0043167//GO:0016307//GO:0005524 ion binding//phosphatidylinositol phosphate kinase activity//ATP binding GO:0016021 integral component of membrane KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.39962 BF_2 525.68 2.61 8725 642933755 XP_008191527.1 6952 0.0e+00 PREDICTED: huntingtin-like [Tribolium castaneum] -- -- -- -- -- K04533 HD huntingtin http://www.genome.jp/dbget-bin/www_bget?ko:K04533 P42858 2531 7.6e-284 Huntingtin OS=Homo sapiens GN=HTT PE=1 SV=2 PF08715//PF02985 Papain like viral protease//HEAT repeat GO:0006508 proteolysis GO:0016740//GO:0008242//GO:0005515//GO:0004197 transferase activity//omega peptidase activity//protein binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.39963 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39965 BF_2 787.15 36.47 1190 642918274 XP_008191440.1 1239 1.7e-133 PREDICTED: purine nucleoside phosphorylase isoform X1 [Tribolium castaneum] 327297537 XM_003233415.1 34 6.65728e-06 Trichophyton rubrum CBS 118892 purine nucleoside phosphorylase (TERG_06452) mRNA, complete cds K03783 punA purine-nucleoside phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K03783 P55859 815 9.9e-86 Purine nucleoside phosphorylase OS=Bos taurus GN=PNP PE=1 SV=3 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- KOG3984 Purine nucleoside phosphorylase Cluster-8309.39967 BF_2 77.16 2.76 1458 332374874 AEE62578.1 518 8.2e-50 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1HRV8 330 2.1e-29 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.39968 BF_2 93.56 0.81 5099 589060796 AHK26791.1 193 1.4e-11 eukaryotic translation initiation factor 4A [Epicauta chinensis] -- -- -- -- -- K03257 EIF4A translation initiation factor 4A http://www.genome.jp/dbget-bin/www_bget?ko:K03257 Q5R4X1 167 5.9e-10 Eukaryotic initiation factor 4A-II OS=Pongo abelii GN=EIF4A2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0328 Predicted ATP-dependent RNA helicase FAL1, involved in rRNA maturation, DEAD-box superfamily Cluster-8309.39969 BF_2 895.69 14.95 2793 642923048 XP_008200509.1 2851 0.0e+00 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923050|ref|XP_008200510.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923052|ref|XP_008200511.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJP5 1114 5.0e-120 Fibronectin type-III domain-containing protein 3a OS=Gallus gallus GN=FNDC3A PE=2 SV=2 PF16794//PF16656//PF00041 Fibronectin-III type domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.39970 BF_2 66.34 1.14 2726 642923048 XP_008200509.1 2162 3.5e-240 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923050|ref|XP_008200510.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum]>gi|642923052|ref|XP_008200511.1| PREDICTED: fibronectin type-III domain-containing protein 3A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJP5 1077 9.5e-116 Fibronectin type-III domain-containing protein 3a OS=Gallus gallus GN=FNDC3A PE=2 SV=2 PF16794//PF00041//PF16656 Fibronectin-III type domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.39971 BF_2 8.70 1.10 618 727098952 AIY54301.1 682 3.3e-69 ribosomal protein L32e [Colaphellus bowringi] 727098951 KJ534560.1 204 1.05873e-100 Colaphellus bowringi ribosomal protein L32e (RPL32e) mRNA, complete cds K02912 RP-L32e, RPL32 large subunit ribosomal protein L32e http://www.genome.jp/dbget-bin/www_bget?ko:K02912 Q8WRF3 637 2.2e-65 60S ribosomal protein L32 OS=Apis mellifera GN=RpL32 PE=2 SV=1 PF01655 Ribosomal protein L32 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0878 60S ribosomal protein L32 Cluster-8309.39972 BF_2 56.95 0.70 3672 642936428 XP_008198430.1 1462 7.1e-159 PREDICTED: probable RISC-loading complex subunit BRAFLDRAFT_242885 isoform X2 [Tribolium castaneum] 462325532 APGK01041790.1 74 1.2171e-27 Dendroctonus ponderosae Seq01041800, whole genome shotgun sequence K18420 TARBP2 RISC-loading complex subunit TARBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K18420 Q4SS66 532 2.0e-52 RISC-loading complex subunit tarbp2 OS=Tetraodon nigroviridis GN=tarbp2 PE=3 SV=1 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.39973 BF_2 711.79 24.73 1491 270003289 EEZ99736.1 605 6.8e-60 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62101 128 5.7e-06 Serine/threonine-protein kinase D1 OS=Mus musculus GN=Prkd1 PE=1 SV=2 PF09202//PF00130 Rio2, N-terminal//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0009069//GO:0035556//GO:0006468//GO:0016310 serine family amino acid metabolic process//intracellular signal transduction//protein phosphorylation//phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.39975 BF_2 2332.30 15.13 6736 642912527 XP_008200900.1 856 2.4e-88 PREDICTED: zinc finger C4H2 domain-containing protein isoform X2 [Tribolium castaneum]>gi|270002588|gb|EEZ99035.1| hypothetical protein TcasGA2_TC004909 [Tribolium castaneum] 752869764 XM_011253703.1 73 8.06254e-27 PREDICTED: Camponotus floridanus zinc finger C4H2 domain-containing protein (LOC105248746), transcript variant X4, mRNA -- -- -- -- Q9NQZ6 443 7.7e-42 Zinc finger C4H2 domain-containing protein OS=Homo sapiens GN=ZC4H2 PE=1 SV=1 PF03854//PF02251//PF00769//PF03229 P-11 zinc finger//Proteasome activator pa28 alpha subunit//Ezrin/radixin/moesin family//Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process GO:0008270//GO:0003723//GO:0008092 zinc ion binding//RNA binding//cytoskeletal protein binding GO:0019898//GO:0008537//GO:0005737 extrinsic component of membrane//proteasome activator complex//cytoplasm -- -- Cluster-8309.39976 BF_2 7.00 2.16 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39977 BF_2 83.38 0.67 5456 189237995 XP_001812873.1 4909 0.0e+00 PREDICTED: protein outspread [Tribolium castaneum] 642925058 XM_008195932.1 51 1.10747e-14 PREDICTED: Tribolium castaneum tectonin beta-propeller repeat-containing protein (LOC100141852), transcript variant X5, mRNA -- -- -- -- Q27421 628 2.2e-63 Protein outspread OS=Drosophila melanogaster GN=osp PE=2 SV=5 PF00367 phosphotransferase system, EIIB GO:0008643 carbohydrate transport GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4807 F-actin binding protein, regulates actin cytoskeletal organization Cluster-8309.39978 BF_2 1760.62 14.41 5397 189237995 XP_001812873.1 4940 0.0e+00 PREDICTED: protein outspread [Tribolium castaneum] 642925058 XM_008195932.1 51 1.09541e-14 PREDICTED: Tribolium castaneum tectonin beta-propeller repeat-containing protein (LOC100141852), transcript variant X5, mRNA -- -- -- -- Q27421 628 2.2e-63 Protein outspread OS=Drosophila melanogaster GN=osp PE=2 SV=5 PF00367 phosphotransferase system, EIIB GO:0008643 carbohydrate transport GO:0008982 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0009357 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4807 F-actin binding protein, regulates actin cytoskeletal organization Cluster-8309.39980 BF_2 269.61 6.00 2166 478253499 ENN73826.1 1562 1.1e-170 hypothetical protein YQE_09604, partial [Dendroctonus ponderosae] 195146567 XM_002014220.1 155 6.69529e-73 Drosophila persimilis gpdh (Dper\Gpdh), mRNA K00006 GPD1 glycerol-3-phosphate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00006 P13706 1395 1.0e-152 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Drosophila melanogaster GN=Gpdh PE=1 SV=3 PF07479//PF01210 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GO:0046168//GO:0006072//GO:0005975//GO:0046486//GO:0055114 glycerol-3-phosphate catabolic process//glycerol-3-phosphate metabolic process//carbohydrate metabolic process//glycerolipid metabolic process//oxidation-reduction process GO:0016616//GO:0051287//GO:0004367 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0009331 glycerol-3-phosphate dehydrogenase complex KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase Cluster-8309.39981 BF_2 1.00 2.66 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39983 BF_2 53.09 0.63 3827 91088677 XP_974860.1 748 4.6e-76 PREDICTED: probable aconitate hydratase, mitochondrial [Tribolium castaneum]>gi|270011673|gb|EFA08121.1| hypothetical protein TcasGA2_TC005725 [Tribolium castaneum] 743728916 XM_010960233.1 74 1.26898e-27 PREDICTED: Camelus bactrianus aconitase 2, mitochondrial (ACO2), mRNA K01681 ACO, acnA aconitate hydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01681 P20004 648 7.4e-66 Aconitate hydratase, mitochondrial OS=Bos taurus GN=ACO2 PE=1 SV=4 PF00694 Aconitase C-terminal domain GO:0019643//GO:0046487//GO:0006099//GO:0008152 reductive tricarboxylic acid cycle//glyoxylate metabolic process//tricarboxylic acid cycle//metabolic process GO:0051539//GO:0003994 4 iron, 4 sulfur cluster binding//aconitate hydratase activity -- -- KOG0453 Aconitase/homoaconitase (aconitase superfamily) Cluster-8309.39986 BF_2 87.24 1.27 3160 642927886 XP_001813556.2 1242 2.0e-133 PREDICTED: follistatin [Tribolium castaneum] -- -- -- -- -- K04661 FST follistatin http://www.genome.jp/dbget-bin/www_bget?ko:K04661 P31514 643 2.3e-65 Follistatin (Fragment) OS=Ovis aries GN=FST PE=2 SV=1 PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.39987 BF_2 95.95 1.35 3252 642931697 XP_008196692.1 1943 1.0e-214 PREDICTED: uncharacterized protein LOC657740 isoform X1 [Tribolium castaneum]>gi|270012781|gb|EFA09229.1| stem cell tumour protein [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 576 1.4e-57 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF13499//PF13405//PF00036//PF01694 EF-hand domain pair//EF-hand domain//EF hand//Rhomboid family GO:0006508 proteolysis GO:0004252//GO:0005509 serine-type endopeptidase activity//calcium ion binding GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.39988 BF_2 27.11 0.39 3211 642916169 XP_008190915.1 943 9.4e-99 PREDICTED: uncharacterized protein LOC103312328 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39990 BF_2 243.03 3.59 3116 642938354 XP_008198798.1 565 6.2e-55 PREDICTED: peptidyl-prolyl cis-trans isomerase G [Tribolium castaneum] 645259408 XM_008237125.1 62 4.83076e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 A2AR02 448 9.4e-43 Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus GN=Ppig PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.39992 BF_2 91.00 2.06 2132 642930848 XP_008196112.1 309 2.0e-25 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.39995 BF_2 2868.12 34.06 3810 478256345 ENN76535.1 247 5.7e-18 hypothetical protein YQE_06986, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04623//PF01442//PF07464 Adenovirus E1B protein N-terminus//Apolipoprotein A1/A4/E domain//Apolipophorin-III precursor (apoLp-III) GO:0006869//GO:0009605//GO:0042157 lipid transport//response to external stimulus//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.39996 BF_2 654.40 3.57 7951 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.66884e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF05680//PF00637//PF01165//PF13639//PF12861//PF00569//PF00443//PF14634//PF02723//PF02148//PF12678//PF17122//PF00097 ATP synthase E chain//Region in Clathrin and VPS//Ribosomal protein S21//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, ZZ type//Ubiquitin carboxyl-terminal hydrolase//zinc-RING finger domain//Non-structural protein NS3/Small envelope protein E//Zn-finger in ubiquitin-hydrolases and other protein//RING-H2 zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger) GO:0016579//GO:0015992//GO:0042254//GO:0006886//GO:0016192//GO:0015986//GO:0006412//GO:0016567 protein deubiquitination//proton transport//ribosome biogenesis//intracellular protein transport//vesicle-mediated transport//ATP synthesis coupled proton transport//translation//protein ubiquitination GO:0015078//GO:0003735//GO:0008270//GO:0036459//GO:0046872//GO:0005515//GO:0004842 hydrogen ion transmembrane transporter activity//structural constituent of ribosome//zinc ion binding//ubiquitinyl hydrolase activity//metal ion binding//protein binding//ubiquitin-protein transferase activity GO:0005840//GO:0016020//GO:0000276//GO:0005680 ribosome//membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//anaphase-promoting complex KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.39997 BF_2 341.67 2.83 5340 642930363 XP_008196367.1 971 8.8e-102 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.76244e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.39998 BF_2 5705.04 51.92 4884 642930363 XP_008196367.1 908 1.6e-94 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.43897e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P55828 475 1.1e-45 40S ribosomal protein S20 OS=Drosophila melanogaster GN=RpS20 PE=1 SV=1 PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.39999 BF_2 35.00 6.00 531 642930421 XP_008196394.1 389 2.7e-35 PREDICTED: tyrosine-protein kinase hopscotch [Tribolium castaneum] -- -- -- -- -- K04447 JAK2 Janus kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40001 BF_2 341.98 2.13 7011 642926249 XP_974073.3 1626 1.3e-177 PREDICTED: mannose-1-phosphate guanyltransferase beta [Tribolium castaneum]>gi|270009027|gb|EFA05475.1| hypothetical protein TcasGA2_TC015659 [Tribolium castaneum] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q295Y7 1534 2.5e-168 Mannose-1-phosphate guanyltransferase beta OS=Drosophila pseudoobscura pseudoobscura GN=GA10892 PE=3 SV=1 PF09270//PF01128//PF02932//PF08671//PF00483//PF06459//PF07959//PF00076 Beta-trefoil DNA-binding domain//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//Neurotransmitter-gated ion-channel transmembrane region//Anti-repressor SinI//Nucleotidyl transferase//Ryanodine Receptor TM 4-6//L-fucokinase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006811//GO:0006355//GO:0006694//GO:0009058//GO:0006874//GO:0006816//GO:0008299 ion transport//regulation of transcription, DNA-templated//steroid biosynthetic process//biosynthetic process//cellular calcium ion homeostasis//calcium ion transport//isoprenoid biosynthetic process GO:0003676//GO:0046983//GO:0005219//GO:0000982//GO:0016772//GO:0016779//GO:0000978//GO:0050518 nucleic acid binding//protein dimerization activity//ryanodine-sensitive calcium-release channel activity//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//transferase activity, transferring phosphorus-containing groups//nucleotidyltransferase activity//RNA polymerase II core promoter proximal region sequence-specific DNA binding//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity GO:0016020//GO:0005634//GO:0005622//GO:0016021 membrane//nucleus//intracellular//integral component of membrane KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.40005 BF_2 8828.37 117.55 3429 478256345 ENN76535.1 247 5.1e-18 hypothetical protein YQE_06986, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07464//PF01442//PF04623 Apolipophorin-III precursor (apoLp-III)//Apolipoprotein A1/A4/E domain//Adenovirus E1B protein N-terminus GO:0042157//GO:0009605//GO:0006869 lipoprotein metabolic process//response to external stimulus//lipid transport GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.40007 BF_2 364.67 7.48 2327 91078348 XP_973652.1 1386 2.9e-150 PREDICTED: prostaglandin E synthase 2 [Tribolium castaneum]>gi|270003893|gb|EFA00341.1| hypothetical protein TcasGA2_TC003180 [Tribolium castaneum] -- -- -- -- -- K05309 PTGES2 microsomal prostaglandin-E synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05309 Q9N0A4 674 4.4e-69 Prostaglandin E synthase 2 OS=Macaca fascicularis GN=PTGES2 PE=1 SV=1 PF02798//PF00462//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutaredoxin//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0009055//GO:0015035//GO:0005515 electron carrier activity//protein disulfide oxidoreductase activity//protein binding -- -- KOG3029 Glutathione S-transferase-related protein Cluster-8309.40008 BF_2 2057.92 15.01 6023 546682084 ERL92070.1 2226 3.0e-247 hypothetical protein D910_09392, partial [Dendroctonus ponderosae] 755993244 XM_011315162.1 85 1.53831e-33 PREDICTED: Fopius arisanus inorganic pyrophosphatase (LOC105272929), mRNA K09583 PDIA5 protein disulfide isomerase family A, member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09583 Q5I0H9 1046 8.2e-112 Protein disulfide-isomerase A5 OS=Rattus norvegicus GN=Pdia5 PE=2 SV=1 PF00719//PF00085//PF08534//PF07689//PF00462//PF00578//PF01323 Inorganic pyrophosphatase//Thioredoxin//Redoxin//KaiB domain//Glutaredoxin//AhpC/TSA family//DSBA-like thioredoxin domain GO:0006796//GO:0006119//GO:0048511//GO:0045454//GO:0055114//GO:0006118 phosphate-containing compound metabolic process//oxidative phosphorylation//rhythmic process//cell redox homeostasis//oxidation-reduction process//obsolete electron transport GO:0016491//GO:0004427//GO:0000287//GO:0015035//GO:0016209//GO:0009055 oxidoreductase activity//inorganic diphosphatase activity//magnesium ion binding//protein disulfide oxidoreductase activity//antioxidant activity//electron carrier activity GO:0005737 cytoplasm KOG1626 Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 Cluster-8309.40009 BF_2 51.05 0.37 6083 546682084 ERL92070.1 2226 3.0e-247 hypothetical protein D910_09392, partial [Dendroctonus ponderosae] 755993244 XM_011315162.1 85 1.55373e-33 PREDICTED: Fopius arisanus inorganic pyrophosphatase (LOC105272929), mRNA K09583 PDIA5 protein disulfide isomerase family A, member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09583 Q5I0H9 1046 8.3e-112 Protein disulfide-isomerase A5 OS=Rattus norvegicus GN=Pdia5 PE=2 SV=1 PF08534//PF00719//PF00085//PF07689//PF00578//PF00462//PF01323 Redoxin//Inorganic pyrophosphatase//Thioredoxin//KaiB domain//AhpC/TSA family//Glutaredoxin//DSBA-like thioredoxin domain GO:0048511//GO:0006796//GO:0006119//GO:0006118//GO:0055114//GO:0045454 rhythmic process//phosphate-containing compound metabolic process//oxidative phosphorylation//obsolete electron transport//oxidation-reduction process//cell redox homeostasis GO:0004427//GO:0016491//GO:0016209//GO:0015035//GO:0009055//GO:0000287 inorganic diphosphatase activity//oxidoreductase activity//antioxidant activity//protein disulfide oxidoreductase activity//electron carrier activity//magnesium ion binding GO:0005737 cytoplasm KOG1626 Inorganic pyrophosphatase/Nucleosome remodeling factor, subunit NURF38 Cluster-8309.40010 BF_2 99.87 0.60 7216 91079915 XP_967163.1 3071 0.0e+00 PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|642918342|ref|XP_008196887.1| PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|270003264|gb|EEZ99711.1| hypothetical protein TcasGA2_TC002472 [Tribolium castaneum] 642918341 XM_008198665.1 668 0 PREDICTED: Tribolium castaneum cold shock domain-containing protein E1 (LOC655517), transcript variant X2, mRNA -- -- -- -- P18395 1330 1.2e-144 Cold shock domain-containing protein E1 OS=Rattus norvegicus GN=Csde1 PE=2 SV=1 PF00313//PF02099 'Cold-shock' DNA-binding domain//Josephin GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008242 DNA binding//omega peptidase activity -- -- KOG2935 Ataxin 3/Josephin Cluster-8309.40012 BF_2 240.02 2.29 4666 642922644 XP_971277.2 3230 0.0e+00 PREDICTED: zinc finger protein ush isoform X2 [Tribolium castaneum] 642922643 XM_966184.2 48 4.40152e-13 PREDICTED: Tribolium castaneum zinc finger protein u-shaped (LOC659918), transcript variant X2, mRNA K17441 ZFPM1, FOG1 zinc finger protein ZFPM1 http://www.genome.jp/dbget-bin/www_bget?ko:K17441 Q9VPQ6 831 5.4e-87 Zinc finger protein ush OS=Drosophila melanogaster GN=ush PE=1 SV=2 PF05221//PF16622//PF13465//PF00096 S-adenosyl-L-homocysteine hydrolase//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006555//GO:0006730 methionine metabolic process//one-carbon metabolic process GO:0046872//GO:0004013 metal ion binding//adenosylhomocysteinase activity -- -- -- -- Cluster-8309.40014 BF_2 27.00 0.68 1947 332376933 AEE63606.1 1163 1.8e-124 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00927 PGK, pgk phosphoglycerate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00927 Q01604 1026 5.6e-110 Phosphoglycerate kinase OS=Drosophila melanogaster GN=Pgk PE=2 SV=2 PF00162 Phosphoglycerate kinase GO:0006094//GO:0006096//GO:0015976//GO:0016310 gluconeogenesis//glycolytic process//carbon utilization//phosphorylation GO:0004618 phosphoglycerate kinase activity -- -- KOG1367 3-phosphoglycerate kinase Cluster-8309.40015 BF_2 5428.47 91.76 2762 91081249 XP_975650.1 644 3.8e-64 PREDICTED: membrane-associated progesterone receptor component 1 [Tribolium castaneum]>gi|270006068|gb|EFA02516.1| hypothetical protein TcasGA2_TC008221 [Tribolium castaneum] -- -- -- -- -- K17278 PGRMC1_2 membrane-associated progesterone receptor component http://www.genome.jp/dbget-bin/www_bget?ko:K17278 Q5ZKN2 382 3.7e-35 Membrane-associated progesterone receptor component 1 OS=Gallus gallus GN=PGRMC1 PE=2 SV=3 -- -- -- -- GO:0020037 heme binding -- -- KOG1110 Putative steroid membrane receptor Hpr6.6/25-Dx Cluster-8309.40016 BF_2 1965.14 57.13 1726 576251521 AHH29345.1 835 1.7e-86 vacuolar H[+]-ATPase E subunit [Leptinotarsa decemlineata] 195389988 XM_002053615.1 144 6.92143e-67 Drosophila virilis GJ23234 (Dvir\GJ23234), mRNA K02150 ATPeV1E, ATP6E V-type H+-transporting ATPase subunit E http://www.genome.jp/dbget-bin/www_bget?ko:K02150 P31402 639 3.7e-65 V-type proton ATPase subunit E OS=Manduca sexta GN=VHA26 PE=2 SV=1 PF01481//PF00191//PF01991 Arterivirus nucleocapsid protein//Annexin//ATP synthase (E/31 kDa) subunit GO:0006119//GO:0015991//GO:0015992 oxidative phosphorylation//ATP hydrolysis coupled proton transport//proton transport GO:0005544//GO:0046961//GO:0005509 calcium-dependent phospholipid binding//proton-transporting ATPase activity, rotational mechanism//calcium ion binding GO:0033178//GO:0019013 proton-transporting two-sector ATPase complex, catalytic domain//viral nucleocapsid KOG1664 Vacuolar H+-ATPase V1 sector, subunit E Cluster-8309.40017 BF_2 15.03 1.22 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40019 BF_2 564.50 7.80 3313 91078322 XP_972953.1 981 3.8e-103 PREDICTED: pyridoxal kinase [Tribolium castaneum]>gi|270003960|gb|EFA00408.1| hypothetical protein TcasGA2_TC003259 [Tribolium castaneum] -- -- -- -- -- K00868 pdxK, pdxY pyridoxine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00868 O00764 739 1.8e-76 Pyridoxal kinase OS=Homo sapiens GN=PDXK PE=1 SV=1 PF08656//PF07716//PF00170 DASH complex subunit Dad3//Basic region leucine zipper//bZIP transcription factor GO:0042816//GO:0009443//GO:0008608//GO:0006355 vitamin B6 metabolic process//pyridoxal 5'-phosphate salvage//attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated GO:0008478//GO:0003700//GO:0043565 pyridoxal kinase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0072686//GO:0042729 transcription factor complex//mitotic spindle//DASH complex KOG2599 Pyridoxal/pyridoxine/pyridoxamine kinase Cluster-8309.40021 BF_2 53.86 0.45 5257 642912009 XP_008199058.1 1160 1.1e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X1 [Tribolium castaneum]>gi|270014484|gb|EFA10932.1| hypothetical protein TcasGA2_TC001759 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40022 BF_2 15.06 0.42 1798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40023 BF_2 156.34 1.28 5414 642912011 XP_008199059.1 1160 1.1e-123 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05373//PF02892 L-proline 3-hydroxylase, C-terminal//BED zinc finger GO:0055114 oxidation-reduction process GO:0003677//GO:0016706 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.40024 BF_2 889.63 14.23 2903 332373440 AEE61861.1 1517 2.3e-165 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RDN7 1071 5.0e-115 Carboxypeptidase Q OS=Pongo abelii GN=CPQ PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2195 Transferrin receptor and related proteins containing the protease-associated (PA) domain Cluster-8309.40026 BF_2 121.73 2.09 2719 91085939 XP_970530.1 645 2.8e-64 PREDICTED: longitudinals lacking protein-like [Tribolium castaneum]>gi|270010169|gb|EFA06617.1| hypothetical protein TcasGA2_TC009535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KRI2 601 1.5e-60 Longitudinals lacking protein-like OS=Drosophila melanogaster GN=lolal PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40027 BF_2 178.65 1.51 5231 91090858 XP_967143.1 1197 5.4e-128 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] 688710729 LL320824.1 36 2.31404e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 898 1.0e-94 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191//PF01580//PF00270//PF04851//PF02562//PF00580//PF06733 Annexin//FtsK/SpoIIIE family//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//PhoH-like protein//UvrD/REP helicase N-terminal domain//DEAD_2 -- -- GO:0004003//GO:0003676//GO:0005509//GO:0000166//GO:0005544//GO:0003677//GO:0016787//GO:0005524 ATP-dependent DNA helicase activity//nucleic acid binding//calcium ion binding//nucleotide binding//calcium-dependent phospholipid binding//DNA binding//hydrolase activity//ATP binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.40028 BF_2 970.85 26.97 1793 642936042 XP_008198279.1 1235 7.2e-133 PREDICTED: annexin B9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 905 5.5e-96 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- KOG0819 Annexin Cluster-8309.40029 BF_2 41.45 2.95 875 665792068 XP_008543619.1 219 2.3e-15 PREDICTED: zinc finger protein 888-like [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P17010 167 1.0e-10 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40032 BF_2 155.71 2.63 2767 91084963 XP_971862.1 1796 9.9e-198 PREDICTED: GPI mannosyltransferase 4 [Tribolium castaneum]>gi|270009003|gb|EFA05451.1| hypothetical protein TcasGA2_TC015632 [Tribolium castaneum] -- -- -- -- -- K08098 PIGZ, SMP3 phosphatidylinositol glycan, class Z http://www.genome.jp/dbget-bin/www_bget?ko:K08098 Q8MT80 1131 5.3e-122 GPI mannosyltransferase 4 OS=Drosophila melanogaster GN=CG45068 PE=2 SV=1 PF03901//PF04428//PF06703 Alg9-like mannosyltransferase family//Choline kinase N terminus//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233//GO:0016773//GO:0016757 peptidase activity//phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring glycosyl groups GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane KOG4123 Putative alpha 1,2 mannosyltransferase Cluster-8309.40033 BF_2 421.93 3.56 5249 189239140 XP_001806913.1 1410 1.1e-152 PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|642928372|ref|XP_008192716.1| PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|270010787|gb|EFA07235.1| hypothetical protein TcasGA2_TC010592 [Tribolium castaneum] 657809175 XM_008333639.1 51 1.06517e-14 PREDICTED: Cynoglossus semilaevis TSC22 domain family protein 2-like (LOC103395840), transcript variant X2, mRNA -- -- -- -- Q24523 204 3.1e-14 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 PF00170//PF06005//PF04977//PF06156//PF01486//PF11365//PF07716//PF00038//PF01166//PF07926//PF04799 bZIP transcription factor//Protein of unknown function (DUF904)//Septum formation initiator//Protein of unknown function (DUF972)//K-box region//Protein of unknown function (DUF3166)//Basic region leucine zipper//Intermediate filament protein//TSC-22/dip/bun family//TPR/MLP1/MLP2-like protein//fzo-like conserved region GO:0010506//GO:0007049//GO:0006606//GO:0006355//GO:0006260//GO:0000917//GO:0043093//GO:0008053 regulation of autophagy//cell cycle//protein import into nucleus//regulation of transcription, DNA-templated//DNA replication//barrier septum assembly//FtsZ-dependent cytokinesis//mitochondrial fusion GO:0005198//GO:0003924//GO:0003700//GO:0043565 structural molecule activity//GTPase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005882//GO:0016021//GO:0005615//GO:0005737//GO:0005667//GO:0005634//GO:0005741 intermediate filament//integral component of membrane//extracellular space//cytoplasm//transcription factor complex//nucleus//mitochondrial outer membrane KOG4797 Transcriptional regulator Cluster-8309.40034 BF_2 2138.00 109.23 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424 REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0042025 transcription factor complex//host cell nucleus -- -- Cluster-8309.40036 BF_2 753.52 25.97 1501 332376807 AEE63543.1 1800 1.9e-198 unknown [Dendroctonus ponderosae] 645003053 XM_008209892.1 41 1.08535e-09 PREDICTED: Nasonia vitripennis kynurenine--oxoglutarate transaminase 3-like (LOC100119206), mRNA K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 1245 1.7e-135 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF00155//PF01053 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.40038 BF_2 1673.34 12.01 6117 546670634 ERL83320.1 5513 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.47037e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 8.1e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF13499//PF06337//PF05191//PF13405//PF00036//PF00443//PF11421 EF-hand domain pair//DUSP domain//Adenylate kinase, active site lid//EF-hand domain//EF hand//Ubiquitin carboxyl-terminal hydrolase//ATP synthase F1 beta subunit GO:0006144//GO:0046034//GO:0006508//GO:0006754//GO:0016579 purine nucleobase metabolic process//ATP metabolic process//proteolysis//ATP biosynthetic process//protein deubiquitination GO:0005524//GO:0036459//GO:0004843//GO:0005509//GO:0016887//GO:0004017 ATP binding//ubiquitinyl hydrolase activity//ubiquitin-specific protease activity//calcium ion binding//ATPase activity//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.40040 BF_2 328.27 6.65 2353 270010227 EFA06675.1 1693 7.4e-186 hypothetical protein TcasGA2_TC009605 [Tribolium castaneum] -- -- -- -- -- K06776 PTPRK receptor-type tyrosine-protein phosphatase kappa http://www.genome.jp/dbget-bin/www_bget?ko:K06776 Q15262 809 9.8e-85 Receptor-type tyrosine-protein phosphatase kappa OS=Homo sapiens GN=PTPRK PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.40043 BF_2 5882.29 54.85 4773 642931693 XP_972683.3 3792 0.0e+00 PREDICTED: DNA-directed RNA polymerase I subunit RPA2 [Tribolium castaneum] 807042134 XM_004536258.2 113 3.31302e-49 PREDICTED: Ceratitis capitata DNA-directed RNA polymerase I subunit RPA2 (LOC101449376), mRNA K03002 RPA2, POLR1B DNA-directed RNA polymerase I subunit RPA2 http://www.genome.jp/dbget-bin/www_bget?ko:K03002 P20028 2885 0.0e+00 DNA-directed RNA polymerase I subunit RPA2 OS=Drosophila melanogaster GN=RpI135 PE=2 SV=2 PF04561//PF13442//PF04560//PF00562//PF04565//PF06883//PF00034 RNA polymerase Rpb2, domain 2//Cytochrome C oxidase, cbb3-type, subunit III//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 6//RNA polymerase Rpb2, domain 3//RNA polymerase I, Rpa2 specific domain//Cytochrome c GO:0006206//GO:0006118//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//obsolete electron transport//purine nucleobase metabolic process//transcription, DNA-templated GO:0020037//GO:0009055//GO:0003677//GO:0003899 heme binding//electron carrier activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus KOG0216 RNA polymerase I, second largest subunit Cluster-8309.40045 BF_2 140.86 1.52 4172 642936134 XP_008198313.1 3421 0.0e+00 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 723 0 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q8T674 926 4.7e-98 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF03193//PF00005//PF13304//PF01061 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC-2 type transporter -- -- GO:0005524//GO:0005525//GO:0016887//GO:0003924 ATP binding//GTP binding//ATPase activity//GTPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.40048 BF_2 140.31 1.40 4469 91080499 XP_971142.1 1128 4.6e-120 PREDICTED: 5'-AMP-activated protein kinase subunit beta-1 [Tribolium castaneum]>gi|270005556|gb|EFA02004.1| hypothetical protein TcasGA2_TC007626 [Tribolium castaneum] 332376520 BT128443.1 148 1.08399e-68 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 1.4e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF02922//PF07503//PF00098//PF06495//PF00096//PF08675//PF02892//PF04739//PF13912//PF16622//PF00320//PF13465//PF05443//PF00076 Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//HypF finger//Zinc knuckle//Fruit fly transformer protein//Zinc finger, C2H2 type//RNA binding domain//BED zinc finger//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//zinc-finger C2H2-type//GATA zinc finger//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006397//GO:0006402//GO:0051252//GO:0005975//GO:0046660//GO:0006355 mRNA processing//mRNA catabolic process//regulation of RNA metabolic process//carbohydrate metabolic process//female sex differentiation//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0003723//GO:0046872//GO:0003676//GO:0004553//GO:0003700//GO:0004535//GO:0008270//GO:0043565 protein binding//DNA binding//RNA binding//metal ion binding//nucleic acid binding//hydrolase activity, hydrolyzing O-glycosyl compounds//transcription factor activity, sequence-specific DNA binding//poly(A)-specific ribonuclease activity//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm KOG1616 Protein involved in Snf1 protein kinase complex assembly Cluster-8309.40049 BF_2 105.07 1.22 3882 91078854 XP_971956.1 810 3.0e-83 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit C [Tribolium castaneum]>gi|270004131|gb|EFA00579.1| hypothetical protein TcasGA2_TC003449 [Tribolium castaneum] 242023017 XM_002431888.1 35 6.16157e-06 Pediculus humanus corporis Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, putative, mRNA K03859 PIGC, GPI2 phosphatidylinositol glycan, class C http://www.genome.jp/dbget-bin/www_bget?ko:K03859 Q92535 456 1.4e-43 Phosphatidylinositol N-acetylglucosaminyltransferase subunit C OS=Homo sapiens GN=PIGC PE=2 SV=1 PF01158//PF06432 Ribosomal protein L36e//Phosphatidylinositol N-acetylglucosaminyltransferase GO:0006506//GO:0042254//GO:0006412 GPI anchor biosynthetic process//ribosome biogenesis//translation GO:0003735//GO:0017176 structural constituent of ribosome//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0005622//GO:0005840//GO:0016021 intracellular//ribosome//integral component of membrane KOG3452 60S ribosomal protein L36 Cluster-8309.40050 BF_2 388.27 22.35 1014 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40051 BF_2 885.45 32.96 1411 642918470 XP_008191489.1 1818 1.4e-200 PREDICTED: protein NDRG3 isoform X2 [Tribolium castaneum] 462464055 APGK01005064.1 69 2.77294e-25 Dendroctonus ponderosae Seq01005066, whole genome shotgun sequence -- -- -- -- Q5RA95 642 1.4e-65 Protein NDRG3 OS=Pongo abelii GN=NDRG3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2931 Differentiation-related gene 1 protein (NDR1 protein), related proteins Cluster-8309.40053 BF_2 1240.07 21.66 2682 546676376 ERL87398.1 1107 7.5e-118 hypothetical protein D910_04793, partial [Dendroctonus ponderosae] -- -- -- -- -- K13212 LUC7L2 RNA-binding protein Luc7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13212 Q9Y383 866 2.7e-91 Putative RNA-binding protein Luc7-like 2 OS=Homo sapiens GN=LUC7L2 PE=1 SV=2 PF03194//PF00472 LUC7 N_terminus//RF-1 domain GO:0006449//GO:0006376//GO:0006415 regulation of translational termination//mRNA splice site selection//translational termination GO:0003747//GO:0003729 translation release factor activity//mRNA binding GO:0005685//GO:0018444//GO:0005840 U1 snRNP//translation release factor complex//ribosome KOG0796 Spliceosome subunit Cluster-8309.40054 BF_2 818.19 8.49 4320 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 2.9962e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.0e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13855//PF13895//PF03526//PF00560 Leucine rich repeat//Immunoglobulin domain//Colicin E1 (microcin) immunity protein//Leucine Rich Repeat GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0005515//GO:0015643 protein binding//toxic substance binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.40055 BF_2 433.93 7.80 2613 478254653 ENN74894.1 504 6.1e-48 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae]>gi|546676113|gb|ERL87180.1| hypothetical protein D910_04580 [Dendroctonus ponderosae] 291062114 GQ923775.1 67 6.72046e-24 Macrobrachium nipponense ubiquitin-conjugating enzyme (Ubc9) mRNA, complete cds K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 O09181 455 1.2e-43 SUMO-conjugating enzyme UBC9 OS=Mesocricetus auratus GN=UBE2I PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515 protein binding -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.40056 BF_2 3519.66 193.77 1047 91078958 XP_974220.1 800 1.2e-82 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 642916228 XM_969127.2 140 6.94042e-65 PREDICTED: Tribolium castaneum cathepsin B precursor (LOC663066), transcript variant X2, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07858 618 6.1e-63 Cathepsin B OS=Homo sapiens GN=CTSB PE=1 SV=3 PF08127//PF00112 Peptidase family C1 propeptide//Papain family cysteine protease GO:0050790//GO:0006508 regulation of catalytic activity//proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.40057 BF_2 280.70 2.53 4920 546683392 ERL93211.1 2662 6.7e-298 hypothetical protein D910_10507, partial [Dendroctonus ponderosae] 795040839 XM_012011345.1 78 9.76988e-30 PREDICTED: Vollenhovia emeryi integrin beta-PS (LOC105561398), transcript variant X2, mRNA K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 2143 4.2e-239 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 PF03325//PF01437 Herpesvirus polymerase accessory protein//Plexin repeat GO:0006260//GO:0019079 DNA replication//viral genome replication GO:0030337 DNA polymerase processivity factor activity GO:0042575//GO:0016020 DNA polymerase complex//membrane KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.40058 BF_2 2408.01 43.74 2590 546683392 ERL93211.1 2655 2.3e-297 hypothetical protein D910_10507, partial [Dendroctonus ponderosae] 642936324 XM_008200175.1 104 1.8002e-44 PREDICTED: Tribolium castaneum integrin beta-PS (LOC657674), transcript variant X2, mRNA K05719 ITGB1 integrin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05719 P11584 2154 1.2e-240 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.40059 BF_2 23.71 0.32 3349 91081871 XP_968443.1 2530 9.3e-283 PREDICTED: sarcosine dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270006329|gb|EFA02777.1| hypothetical protein TcasGA2_TC008514 [Tribolium castaneum] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q9UL12 1530 3.5e-168 Sarcosine dehydrogenase, mitochondrial OS=Homo sapiens GN=SARDH PE=1 SV=1 PF11501//PF01266 Non structural protein Nsp1//FAD dependent oxidoreductase GO:0006546//GO:0055114//GO:0006544//GO:0006508//GO:0006566//GO:0006563 glycine catabolic process//oxidation-reduction process//glycine metabolic process//proteolysis//threonine metabolic process//L-serine metabolic process GO:0004197//GO:0016817//GO:0004047//GO:0016491//GO:0016788//GO:0016740//GO:0008242 cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//aminomethyltransferase activity//oxidoreductase activity//hydrolase activity, acting on ester bonds//transferase activity//omega peptidase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.40060 BF_2 46.94 0.77 2851 642928048 XP_008200135.1 946 3.7e-99 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 255 2.1e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF09392//PF05104//PF04508 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Ribosome receptor lysine/proline rich region//Viral A-type inclusion protein repeat GO:0015031//GO:0016032//GO:0009405 protein transport//viral process//pathogenesis -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.40061 BF_2 364.21 3.00 5369 255958217 NP_001157690.1 511 1.9e-48 fruitless [Tribolium castaneum]>gi|642913400|ref|XP_008200994.1| PREDICTED: fruitless isoform X1 [Tribolium castaneum]>gi|379324165|gb|AFD01647.1| fruitless zinc-finger B isoform [Tribolium castaneum] 642913399 XM_008202772.1 149 3.62579e-69 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X3, mRNA -- -- -- -- Q8IN81 143 3.8e-07 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF13912//PF01363//PF02892//PF01943//PF00096//PF13465 C2H2-type zinc finger//FYVE zinc finger//BED zinc finger//Polysaccharide biosynthesis protein//Zinc finger, C2H2 type//Zinc-finger double domain GO:0000271 polysaccharide biosynthetic process GO:0046872//GO:0008270//GO:0003676//GO:0003677 metal ion binding//zinc ion binding//nucleic acid binding//DNA binding GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.40062 BF_2 118.55 2.26 2483 642913408 XP_008200998.1 1302 1.7e-140 PREDICTED: fruitless isoform X7 [Tribolium castaneum] 642913407 XM_008202776.1 251 3.31048e-126 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X7, mRNA -- -- -- -- Q8IN81 552 6.5e-55 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF02892//PF00651//PF00096 BED zinc finger//BTB/POZ domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.40063 BF_2 452.27 3.37 5902 642915710 XP_008190770.1 2335 6.7e-260 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.9e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF00621//PF01920 RhoGEF domain//Prefoldin subunit GO:0006457//GO:0043087//GO:0035023 protein folding//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089//GO:0051082 Rho guanyl-nucleotide exchange factor activity//unfolded protein binding GO:0016272 prefoldin complex KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.40064 BF_2 378.32 3.06 5456 189237561 XP_974680.2 988 9.7e-104 PREDICTED: CDK5 and ABL1 enzyme substrate 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TDN4 570 1.2e-56 CDK5 and ABL1 enzyme substrate 1 OS=Homo sapiens GN=CABLES1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4164 Cyclin ik3-1/CABLES Cluster-8309.40065 BF_2 1319.86 9.43 6144 642915710 XP_008190770.1 4183 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X1 [Tribolium castaneum] 752876735 XM_011257478.1 63 2.66359e-21 PREDICTED: Camponotus floridanus rho guanine nucleotide exchange factor 12 (LOC105251006), transcript variant X6, mRNA K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 2.0e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF00595//PF00621//PF13180//PF00130//PF09128 PDZ domain (Also known as DHR or GLGF)//RhoGEF domain//PDZ domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Regulator of G protein signalling-like domain GO:0035556//GO:0035023//GO:0043087 intracellular signal transduction//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding GO:0005737 cytoplasm KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.40069 BF_2 23.34 0.61 1876 332376523 AEE63401.1 1339 6.6e-145 unknown [Dendroctonus ponderosae]>gi|478249799|gb|ENN70306.1| hypothetical protein YQE_12817, partial [Dendroctonus ponderosae]>gi|546682880|gb|ERL92766.1| hypothetical protein D910_10075 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38942 735 3.0e-76 4-hydroxybutyrate coenzyme A transferase OS=Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) GN=cat2 PE=3 SV=3 PF02550 Acetyl-CoA hydrolase/transferase N-terminal domain GO:0006084 acetyl-CoA metabolic process GO:0003824 catalytic activity -- -- KOG2828 Acetyl-CoA hydrolase Cluster-8309.40072 BF_2 113.64 0.82 6071 641682104 XP_008189718.1 666 2.3e-66 PREDICTED: uncharacterized protein LOC100570869 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q96DM1 150 6.6e-08 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF02609 Exonuclease VII small subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.40073 BF_2 25.00 3.48 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40074 BF_2 1306.00 21.06 2881 189236096 XP_973523.2 1913 2.8e-211 PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918899|ref|XP_008191647.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918901|ref|XP_008191648.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918903|ref|XP_008191649.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|642918906|ref|XP_008191650.1| PREDICTED: tubulin-specific chaperone cofactor E-like protein [Tribolium castaneum]>gi|270005619|gb|EFA02067.1| hypothetical protein TcasGA2_TC007700 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5QJ74 711 2.8e-73 Tubulin-specific chaperone cofactor E-like protein OS=Homo sapiens GN=TBCEL PE=1 SV=2 PF01780//PF14560//PF00240//PF00564//PF13855 Ribosomal L37ae protein family//Ubiquitin-like domain//Ubiquitin family//PB1 domain//Leucine rich repeat GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG2982 Uncharacterized conserved protein Cluster-8309.40077 BF_2 22.00 2.32 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40078 BF_2 1196.06 19.20 2893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08127 Peptidase family C1 propeptide GO:0050790//GO:0006508 regulation of catalytic activity//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.4008 BF_2 151.13 4.02 1861 646693425 KDR07697.1 1357 5.4e-147 Proton-coupled amino acid transporter 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- F4ILY9 271 1.9e-22 Amino acid transporter ANTL1 OS=Arabidopsis thaliana GN=At2g42005 PE=2 SV=1 PF03402//PF03845 Vomeronasal organ pheromone receptor family, V1R//Spore germination protein GO:0007606//GO:0019236//GO:0007186//GO:0009847 sensory perception of chemical stimulus//response to pheromone//G-protein coupled receptor signaling pathway//spore germination GO:0016503 pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.40082 BF_2 3018.09 68.40 2133 546685573 ERL95060.1 828 1.3e-85 hypothetical protein D910_12330 [Dendroctonus ponderosae] 642926883 XM_967083.3 40 5.58649e-09 PREDICTED: Tribolium castaneum neuroblastoma, suppression of tumorigenicity 1 (LOC660885), mRNA K19558 NBL1 neuroblastoma suppressor of tumorigenicity 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19558 Q6NZ13 229 1.6e-17 Neuroblastoma suppressor of tumorigenicity 1 OS=Danio rerio GN=nbl1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40083 BF_2 17.45 0.40 2130 546675018 ERL86281.1 937 3.1e-98 hypothetical protein D910_03690 [Dendroctonus ponderosae] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 P32929 671 8.9e-69 Cystathionine gamma-lyase OS=Homo sapiens GN=CTH PE=1 SV=3 PF00155//PF01053//PF01212 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.40084 BF_2 380.67 12.05 1609 546675018 ERL86281.1 1576 1.9e-172 hypothetical protein D910_03690 [Dendroctonus ponderosae] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 Q58DW2 1175 2.4e-127 Cystathionine gamma-lyase OS=Bos taurus GN=CTH PE=2 SV=1 PF00155//PF01212//PF01053 Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0009058//GO:0006520 biosynthetic process//cellular amino acid metabolic process GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.40085 BF_2 176.85 1.87 4248 546676946 ERL87870.1 631 1.9e-62 hypothetical protein D910_05258 [Dendroctonus ponderosae] 817210375 XM_012425850.1 72 1.82383e-26 PREDICTED: Orussus abietinus gamma-aminobutyric acid receptor-associated protein (LOC105700198), mRNA K08341 GABARAP, ATG8, LC3 GABA(A) receptor-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08341 P82890 429 2.0e-40 Low molecular weight phosphotyrosine protein phosphatase 1 OS=Drosophila melanogaster GN=primo-1 PE=2 SV=1 PF00961 LAGLIDADG endonuclease -- -- GO:0004519 endonuclease activity -- -- KOG3217 Protein tyrosine phosphatase Cluster-8309.40086 BF_2 105.00 12.89 628 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40088 BF_2 757.00 9.52 3614 642924598 XP_008194358.1 2853 0.0e+00 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] 642924601 XM_008196138.1 354 0 PREDICTED: Tribolium castaneum rho-associated protein kinase 1 (LOC663533), transcript variant X3, mRNA K04514 ROCK1 Rho-associated protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04514 Q13464 1696 2.1e-187 Rho-associated protein kinase 1 OS=Homo sapiens GN=ROCK1 PE=1 SV=1 PF00069//PF04111//PF07714//PF06005//PF08172//PF00433//PF10473//PF06160//PF08718 Protein kinase domain//Autophagy protein Apg6//Protein tyrosine kinase//Protein of unknown function (DUF904)//CASP C terminal//Protein kinase C terminal domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//Glycolipid transfer protein (GLTP) GO:0006914//GO:0009069//GO:0006468//GO:0006891//GO:0046836//GO:0016310//GO:0000921//GO:0043093//GO:0000917 autophagy//serine family amino acid metabolic process//protein phosphorylation//intra-Golgi vesicle-mediated transport//glycolipid transport//phosphorylation//septin ring assembly//FtsZ-dependent cytokinesis//barrier septum assembly GO:0005524//GO:0045502//GO:0008134//GO:0004674//GO:0017089//GO:0051861//GO:0042803//GO:0004672 ATP binding//dynein binding//transcription factor binding//protein serine/threonine kinase activity//glycolipid transporter activity//glycolipid binding//protein homodimerization activity//protein kinase activity GO:0016021//GO:0005940//GO:0005737//GO:0030286//GO:0005667//GO:0030173 integral component of membrane//septin ring//cytoplasm//dynein complex//transcription factor complex//integral component of Golgi membrane KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.40089 BF_2 445.53 7.72 2702 270007326 EFA03774.1 1529 8.8e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 P56960 841 2.2e-88 Exosome component 10 OS=Mus musculus GN=Exosc10 PE=1 SV=2 PF08066//PF02456//PF01612 PMC2NT (NUC016) domain//Adenovirus IVa2 protein//3'-5' exonuclease GO:0006396//GO:0006139//GO:0019083 RNA processing//nucleobase-containing compound metabolic process//viral transcription GO:0008408//GO:0003676 3'-5' exonuclease activity//nucleic acid binding GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.40090 BF_2 456.40 3.39 5927 332374566 AEE62424.1 484 2.9e-45 unknown [Dendroctonus ponderosae] -- -- -- -- -- K05760 PXN paxillin http://www.genome.jp/dbget-bin/www_bget?ko:K05760 Q8MML5 232 2.0e-17 Paxillin-B OS=Dictyostelium discoideum GN=paxB PE=2 SV=1 PF01258//PF01853//PF00412 Prokaryotic dksA/traR C4-type zinc finger//MOZ/SAS family//LIM domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40091 BF_2 805.98 27.78 1501 642916856 XP_968783.3 998 1.8e-105 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41073 357 1.6e-32 Zinc finger protein on ecdysone puffs OS=Drosophila melanogaster GN=Pep PE=1 SV=1 PF00096//PF04988//PF13912 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.40092 BF_2 232.95 1.30 7775 642938169 XP_008190998.1 1053 4.0e-111 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 470 6.6e-45 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF04644//PF00001//PF06652//PF00002 Motilin/ghrelin//7 transmembrane receptor (rhodopsin family)//Methuselah N-terminus//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186//GO:0006950 signal transduction//G-protein coupled receptor signaling pathway//response to stress GO:0005179//GO:0004930 hormone activity//G-protein coupled receptor activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.40095 BF_2 152.56 0.96 6957 189234221 XP_972511.2 771 1.8e-78 PREDICTED: zinc finger C4H2 domain-containing protein isoform X1 [Tribolium castaneum] 752869764 XM_011253703.1 65 2.33208e-22 PREDICTED: Camponotus floridanus zinc finger C4H2 domain-containing protein (LOC105248746), transcript variant X4, mRNA -- -- -- -- Q9NQZ6 379 2.1e-34 Zinc finger C4H2 domain-containing protein OS=Homo sapiens GN=ZC4H2 PE=1 SV=1 PF03854//PF05715//PF02251//PF00769//PF03229 P-11 zinc finger//Piccolo Zn-finger//Proteasome activator pa28 alpha subunit//Ezrin/radixin/moesin family//Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process GO:0003723//GO:0008092//GO:0046872//GO:0008270 RNA binding//cytoskeletal protein binding//metal ion binding//zinc ion binding GO:0008537//GO:0019898//GO:0005737//GO:0045202 proteasome activator complex//extrinsic component of membrane//cytoplasm//synapse -- -- Cluster-8309.40096 BF_2 5328.11 183.32 1503 642918278 XP_967503.3 720 3.2e-73 PREDICTED: nucleoside diphosphate kinase [Tribolium castaneum] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 P08879 629 4.7e-64 Nucleoside diphosphate kinase OS=Drosophila melanogaster GN=awd PE=1 SV=3 PF00334 Nucleoside diphosphate kinase GO:0006144//GO:0006183//GO:0006228//GO:0006165//GO:0006206//GO:0006241 purine nucleobase metabolic process//GTP biosynthetic process//UTP biosynthetic process//nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.40097 BF_2 876.64 5.32 7177 91083759 XP_971689.1 2098 2.5e-232 PREDICTED: translocation protein SEC63 homolog [Tribolium castaneum] 241591921 XM_002403988.1 183 6.10235e-88 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19028 PFKFB1 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19028 Q91309 1438 3.4e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF01591//PF00973//PF05470//PF06414 6-phosphofructo-2-kinase//Paramyxovirus nucleocapsid protein//Eukaryotic translation initiation factor 3 subunit 8 N-terminus//Zeta toxin GO:0006446//GO:0006000//GO:0006013//GO:0006413 regulation of translational initiation//fructose metabolic process//mannose metabolic process//translational initiation GO:0005198//GO:0003873//GO:0003743//GO:0005524//GO:0016301//GO:0031369 structural molecule activity//6-phosphofructo-2-kinase activity//translation initiation factor activity//ATP binding//kinase activity//translation initiation factor binding GO:0019013//GO:0005852//GO:0005840 viral nucleocapsid//eukaryotic translation initiation factor 3 complex//ribosome KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.40098 BF_2 67.95 1.43 2270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40100 BF_2 26.73 1.58 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40101 BF_2 471.18 2.83 7252 642935775 XP_008198168.1 1750 5.6e-192 PREDICTED: integrin alpha-PS3-like [Tribolium castaneum] -- -- -- -- -- K17595 SPATA2 spermatogenesis-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17595 O44386 660 5.7e-67 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 PF00641//PF08516 Zn-finger in Ran binding protein and others//ADAM cysteine-rich GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.40102 BF_2 2880.04 16.98 7381 646715813 KDR19281.1 1054 2.9e-111 Schwannomin-interacting protein 1 [Zootermopsis nevadensis] 642924593 XM_008196134.1 241 3.59508e-120 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 681 2.1e-69 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.40103 BF_2 855.28 9.78 3944 642917757 XP_008191356.1 425 1.3e-38 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917761 XM_008193136.1 54 1.71631e-16 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF03285 Paralemmin GO:0008360 regulation of cell shape -- -- GO:0016020 membrane -- -- Cluster-8309.40104 BF_2 4519.39 37.33 5351 642917757 XP_008191356.1 961 1.3e-100 PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum]>gi|642917759|ref|XP_008191357.1| PREDICTED: uncharacterized protein LOC100141567 isoform X1 [Tribolium castaneum] 642917758 XM_008193135.1 165 4.60875e-78 PREDICTED: Tribolium castaneum uncharacterized LOC100141567 (LOC100141567), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF03285//PF00199//PF01695 Paralemmin//Catalase//IstB-like ATP binding protein GO:0006979//GO:0006804//GO:0015947//GO:0008360//GO:0055114//GO:0006568 response to oxidative stress//obsolete peroxidase reaction//methane metabolic process//regulation of cell shape//oxidation-reduction process//tryptophan metabolic process GO:0005524//GO:0004096//GO:0020037 ATP binding//catalase activity//heme binding GO:0016020 membrane -- -- Cluster-8309.40108 BF_2 596.03 8.50 3220 91079768 XP_966889.1 792 3.0e-81 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 385 2.0e-35 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF01370//PF00106//PF01073 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008210//GO:0008152 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0016491//GO:0016616//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.40113 BF_2 73.78 0.59 5500 189237182 XP_001808720.1 2170 8.5e-241 PREDICTED: FERM, RhoGEF and pleckstrin domain-containing protein 2-like [Tribolium castaneum] 642922446 XM_008194952.1 244 5.75086e-122 PREDICTED: Tribolium castaneum titin-like (LOC655359), mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 1.2e-117 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF08172//PF00621 CASP C terminal//RhoGEF domain GO:0006891//GO:0043087//GO:0035023 intra-Golgi vesicle-mediated transport//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane KOG3531 Rho guanine nucleotide exchange factor CDEP Cluster-8309.40114 BF_2 2210.76 27.51 3649 91088789 XP_968000.1 859 5.9e-89 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270011625|gb|EFA08073.1| hypothetical protein TcasGA2_TC005669 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35859 291 1.8e-24 Insulin-like growth factor-binding protein complex acid labile subunit OS=Rattus norvegicus GN=Igfals PE=1 SV=1 PF00560//PF13855//PF01943 Leucine Rich Repeat//Leucine rich repeat//Polysaccharide biosynthesis protein GO:0000271 polysaccharide biosynthetic process GO:0005515 protein binding GO:0016020 membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.40115 BF_2 2117.38 7.80 11648 642937892 XP_008200345.1 13462 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 2.1179e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 8471 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF02207//PF03875//PF04410//PF02806//PF03488 Putative zinc finger in N-recognin (UBR box)//Statherin//Gar1/Naf1 RNA binding region//Alpha amylase, C-terminal all-beta domain//Nematode insulin-related peptide beta type GO:0042742//GO:0007165//GO:0030500//GO:0005975//GO:0001522//GO:0042254 defense response to bacterium//signal transduction//regulation of bone mineralization//carbohydrate metabolic process//pseudouridine synthesis//ribosome biogenesis GO:0005179//GO:0046848//GO:0003824//GO:0043169//GO:0008270 hormone activity//hydroxyapatite binding//catalytic activity//cation binding//zinc ion binding GO:0005576 extracellular region KOG1776 Zn-binding protein Push Cluster-8309.40116 BF_2 1096.06 9.65 5038 642924400 XP_008194280.1 612 3.5e-60 PREDICTED: serine/arginine repetitive matrix protein 1 [Tribolium castaneum] -- -- -- -- -- K13171 SRRM1, SRM160 serine/arginine repetitive matrix protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13171 Q8IYB3 439 1.7e-41 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens GN=SRRM1 PE=1 SV=2 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2146 Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) Cluster-8309.40117 BF_2 1163.80 10.29 5019 642924400 XP_008194280.1 564 1.3e-54 PREDICTED: serine/arginine repetitive matrix protein 1 [Tribolium castaneum] -- -- -- -- -- K13171 SRRM1, SRM160 serine/arginine repetitive matrix protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13171 Q8IYB3 415 1.0e-38 Serine/arginine repetitive matrix protein 1 OS=Homo sapiens GN=SRRM1 PE=1 SV=2 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2146 Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) Cluster-8309.40119 BF_2 9.76 0.33 1511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05786 Condensin complex subunit 2 GO:0007076 mitotic chromosome condensation -- -- GO:0000796 condensin complex -- -- Cluster-8309.40120 BF_2 38.22 0.41 4154 817212894 XP_012282646.1 2856 0.0e+00 PREDICTED: armadillo segment polarity protein isoform X1 [Orussus abietinus] 642934620 XM_008199519.1 550 0 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 2821 0.0e+00 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 PF10508//PF02985//PF01602//PF00514 Proteasome non-ATPase 26S subunit//HEAT repeat//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0043248//GO:0006886//GO:0016192 proteasome assembly//intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0030117 membrane coat KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.40122 BF_2 564.90 9.66 2733 642926377 XP_008194900.1 1645 3.2e-180 PREDICTED: serine proteinase stubble [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17538 263 2.3e-21 Chymotrypsinogen B OS=Homo sapiens GN=CTRB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40123 BF_2 130.00 2.40 2556 270010381 EFA06829.1 1047 6.5e-111 hypothetical protein TcasGA2_TC009771 [Tribolium castaneum] -- -- -- -- -- K14782 AATF, BFR2 protein AATF/BFR2 http://www.genome.jp/dbget-bin/www_bget?ko:K14782 Q9JKX4 549 1.5e-54 Protein AATF OS=Mus musculus GN=Aatf PE=1 SV=1 PF08164 Apoptosis-antagonizing transcription factor, C-terminal -- -- -- -- GO:0005634 nucleus KOG2773 Apoptosis antagonizing transcription factor/protein transport protein Cluster-8309.40124 BF_2 279.16 1.53 7930 478254915 ENN75149.1 2582 2.1e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.65135e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.6e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF00665//PF13683//PF01534//PF01392//PF08465 Integrase core domain//Integrase core domain//Frizzled/Smoothened family membrane region//Fz domain//Thymidine kinase from Herpesvirus C-terminal GO:0006230//GO:0015074//GO:0007166//GO:0006206 TMP biosynthetic process//DNA integration//cell surface receptor signaling pathway//pyrimidine nucleobase metabolic process GO:0005515//GO:0005524//GO:0004797 protein binding//ATP binding//thymidine kinase activity GO:0016020 membrane -- -- Cluster-8309.40125 BF_2 5215.03 28.19 8025 478254915 ENN75149.1 2582 2.1e-288 hypothetical protein YQE_08262, partial [Dendroctonus ponderosae] 642915961 XM_008192606.1 346 1.67123e-178 PREDICTED: Tribolium castaneum frizzled 2 (LOC656499), transcript variant X2, mRNA K02375 FZD5_8, fz2 frizzled 5/8 http://www.genome.jp/dbget-bin/www_bget?ko:K02375 Q9VVX3 1950 1.6e-216 Frizzled-2 OS=Drosophila melanogaster GN=fz2 PE=1 SV=1 PF08465//PF01534//PF13683//PF01392//PF00665 Thymidine kinase from Herpesvirus C-terminal//Frizzled/Smoothened family membrane region//Integrase core domain//Fz domain//Integrase core domain GO:0006230//GO:0006206//GO:0015074//GO:0007166 TMP biosynthetic process//pyrimidine nucleobase metabolic process//DNA integration//cell surface receptor signaling pathway GO:0004797//GO:0005524//GO:0005515 thymidine kinase activity//ATP binding//protein binding GO:0016020 membrane -- -- Cluster-8309.40127 BF_2 595.53 4.39 5957 642928815 XP_967995.2 1351 8.5e-146 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 6.9e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40128 BF_2 1602.35 8.62 8066 91091742 XP_966408.1 1295 3.6e-139 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 953 6.7e-101 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF00202//PF02424//PF03431 Aminotransferase class-III//ApbE family//RNA replicase, beta-chain GO:0008152//GO:0019079//GO:0017013//GO:0006144 metabolic process//viral genome replication//protein flavinylation//purine nucleobase metabolic process GO:0003968//GO:0030170//GO:0008483 RNA-directed RNA polymerase activity//pyridoxal phosphate binding//transaminase activity GO:0031379 RNA-directed RNA polymerase complex KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.40129 BF_2 448.00 6.79 3046 642913258 XP_008201460.1 815 6.2e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 174 2.59164e-83 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 712 2.2e-73 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40132 BF_2 292.21 1.53 8287 642918318 XP_008191457.1 4577 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 482691326 XM_001353419.3 176 5.48948e-84 Drosophila pseudoobscura pseudoobscura GA16861 (Dpse\GA16861), partial mRNA K06768 DSCAML1 Down syndrome cell adhesion molecule-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06768 Q9VS29 3560 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF04120//PF00041//PF13895//PF16656//PF07749 Low affinity iron permease//Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0019497//GO:0006771//GO:0055085 hexachlorocyclohexane metabolic process//riboflavin metabolic process//transmembrane transport GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.40134 BF_2 63.86 0.53 5312 2072951 AAC51263.1 199 2.9e-12 putative p150 [Homo sapiens] 18042322 AC074239.5 38 1.81675e-07 Homo sapiens BAC clone CTD-2011N5 from 2, complete sequence -- -- -- -- O00370 194 4.5e-13 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40135 BF_2 264.00 61.66 466 646708946 KDR15061.1 415 2.3e-38 Puromycin-sensitive aminopeptidase [Zootermopsis nevadensis] -- -- -- -- -- K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 P55786 285 1.1e-24 Puromycin-sensitive aminopeptidase OS=Homo sapiens GN=NPEPPS PE=1 SV=2 PF05778 Apolipoprotein CIII (Apo-CIII) GO:0006869//GO:0042157 lipid transport//lipoprotein metabolic process GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.40137 BF_2 445.00 6.11 3333 641658119 XP_008180607.1 298 6.0e-24 PREDICTED: zinc finger protein 62 homolog [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q9NQZ8 290 2.1e-24 Endothelial zinc finger protein induced by tumor necrosis factor alpha OS=Homo sapiens GN=ZNF71 PE=2 SV=1 PF13465//PF08493//PF00096//PF13912//PF02892//PF05191//PF16622 Zinc-finger double domain//Aflatoxin regulatory protein//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0046034//GO:0006144//GO:0045122//GO:0006355 ATP metabolic process//purine nucleobase metabolic process//aflatoxin biosynthetic process//regulation of transcription, DNA-templated GO:0003677//GO:0046872//GO:0004017 DNA binding//metal ion binding//adenylate kinase activity GO:0005634 nucleus -- -- Cluster-8309.40139 BF_2 12612.11 28.97 18498 612342210 AHW99830.1 23493 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 2506 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 19839 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF13499//PF13833//PF02815//PF01365//PF00622//PF06459//PF00487//PF06423//PF00520 EF-hand domain pair//EF-hand domain pair//MIR domain//RIH domain//SPRY domain//Ryanodine Receptor TM 4-6//Fatty acid desaturase//GWT1//Ion transport protein GO:0006506//GO:0006811//GO:0006629//GO:0006874//GO:0006816//GO:0055085//GO:0070588 GPI anchor biosynthetic process//ion transport//lipid metabolic process//cellular calcium ion homeostasis//calcium ion transport//transmembrane transport//calcium ion transmembrane transport GO:0005509//GO:0005262//GO:0005219//GO:0005515//GO:0016746//GO:0005216 calcium ion binding//calcium channel activity//ryanodine-sensitive calcium-release channel activity//protein binding//transferase activity, transferring acyl groups//ion channel activity GO:0016020//GO:0005789//GO:0005622//GO:0016021 membrane//endoplasmic reticulum membrane//intracellular//integral component of membrane KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.40140 BF_2 200.54 1.28 6829 270016479 EFA12925.1 288 1.8e-22 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22897 257 2.9e-20 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.40143 BF_2 37.78 0.87 2104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40145 BF_2 286.42 8.61 1678 167444210 ABZ80666.1 1036 8.1e-110 tollip-like protein [Sitophilus zeamais] -- -- -- -- -- K05402 TOLLIP toll-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05402 A2RUW1 649 2.5e-66 Toll-interacting protein OS=Rattus norvegicus GN=Tollip PE=2 SV=1 PF02845//PF00168 CUE domain//C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40146 BF_2 490.00 8.01 2847 91088771 XP_966660.1 2115 1.0e-234 PREDICTED: mucolipin-3 [Tribolium castaneum]>gi|270012727|gb|EFA09175.1| TRPL [Tribolium castaneum] -- -- -- -- -- K05329 TRPML mucolipin http://www.genome.jp/dbget-bin/www_bget?ko:K05329 Q8R4F0 892 2.8e-94 Mucolipin-3 OS=Mus musculus GN=Mcoln3 PE=1 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3733 Mucolipidin and related proteins (TRML subfamily of transient receptor potential proteins) Cluster-8309.40148 BF_2 103.78 0.48 9265 642924084 XP_008193999.1 5676 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X1 [Tribolium castaneum] 642924089 XM_008195780.1 744 0 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 12 (LOC656353), transcript variant X4, mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q86YW9 2448 3.4e-274 Mediator of RNA polymerase II transcription subunit 12-like protein OS=Homo sapiens GN=MED12L PE=1 SV=2 PF09497 Transcription mediator complex subunit Med12 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.40149 BF_2 1140.00 29.13 1924 478257407 ENN77563.1 205 2.1e-13 hypothetical protein YQE_05859, partial [Dendroctonus ponderosae]>gi|546677746|gb|ERL88525.1| hypothetical protein D910_05911 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40151 BF_2 175.95 2.56 3166 546685504 ERL95002.1 827 2.6e-85 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40154 BF_2 71.12 0.52 5969 270002665 EEZ99112.1 1298 1.2e-139 hypothetical protein TcasGA2_TC005005 [Tribolium castaneum] 817188844 XM_012433587.1 77 4.26859e-29 PREDICTED: Orussus abietinus RING finger protein 44 (LOC105704395), partial mRNA K19041 RNF38_44 E3 ubiquitin-protein ligase RNF38/44 http://www.genome.jp/dbget-bin/www_bget?ko:K19041 Q08CG8 412 2.7e-38 RING finger protein 44 OS=Danio rerio GN=rnf44 PE=2 SV=1 PF00097//PF12906//PF17123//PF12678//PF14634//PF00287//PF12861//PF13639 Zinc finger, C3HC4 type (RING finger)//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Sodium / potassium ATPase beta chain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0006814//GO:0006813//GO:0016567 sodium ion transport//potassium ion transport//protein ubiquitination GO:0008270//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005890//GO:0005680 sodium:potassium-exchanging ATPase complex//anaphase-promoting complex -- -- Cluster-8309.40156 BF_2 31.82 0.44 3287 546676114 ERL87181.1 2053 1.9e-227 hypothetical protein D910_04581 [Dendroctonus ponderosae] 642913385 XM_964220.3 287 4.27239e-146 PREDICTED: Tribolium castaneum metal transporter CNNM4 (LOC657784), mRNA K16302 CNNM metal transporter CNNM http://www.genome.jp/dbget-bin/www_bget?ko:K16302 Q5U2P1 1070 7.4e-115 Metal transporter CNNM2 OS=Rattus norvegicus GN=Cnnm2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2118 Predicted membrane protein, contains two CBS domains Cluster-8309.40157 BF_2 317.42 3.05 4638 332374190 AEE62236.1 1087 2.7e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02967 RP-S2, MRPS2, rpsB small subunit ribosomal protein S2 http://www.genome.jp/dbget-bin/www_bget?ko:K02967 Q9Y399 684 6.0e-70 28S ribosomal protein S2, mitochondrial OS=Homo sapiens GN=MRPS2 PE=1 SV=1 PF02558//PF00318//PF00106//PF01370 Ketopantoate reductase PanE/ApbA//Ribosomal protein S2//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0042254//GO:0055114//GO:0006412//GO:0015940//GO:0008152 ribosome biogenesis//oxidation-reduction process//translation//pantothenate biosynthetic process//metabolic process GO:0008677//GO:0003735//GO:0016491//GO:0003824//GO:0050662 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//oxidoreductase activity//catalytic activity//coenzyme binding GO:0005622//GO:0005840 intracellular//ribosome KOG1205 Predicted dehydrogenase Cluster-8309.40159 BF_2 468.98 5.70 3726 91080723 XP_975387.1 919 6.6e-96 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q99NH3 310 1.1e-26 Guanine nucleotide exchange factor for Rab-3A OS=Rattus norvegicus GN=Rab3il1 PE=1 SV=1 PF02926//PF06008 THUMP domain//Laminin Domain I GO:0045995//GO:0030334//GO:0030155//GO:0007165 regulation of embryonic development//regulation of cell migration//regulation of cell adhesion//signal transduction GO:0003723//GO:0005102 RNA binding//receptor binding -- -- -- -- Cluster-8309.40160 BF_2 2158.96 475.18 477 835482914 AKM70276.1 219 1.2e-15 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03823 Neurokinin B GO:0007217 tachykinin receptor signaling pathway -- -- -- -- -- -- Cluster-8309.40162 BF_2 1296.00 43.24 1541 91083421 XP_969043.1 1251 8.7e-135 PREDICTED: 26S proteasome non-ATPase regulatory subunit 7 [Tribolium castaneum]>gi|270006893|gb|EFA03341.1| hypothetical protein TcasGA2_TC013318 [Tribolium castaneum] 817071326 XM_012402300.1 267 2.59749e-135 PREDICTED: Athalia rosae 26S proteasome non-ATPase regulatory subunit 7 (LOC105686998), mRNA K03038 PSMD7, RPN8 26S proteasome regulatory subunit N8 http://www.genome.jp/dbget-bin/www_bget?ko:K03038 P26270 1170 8.8e-127 26S proteasome non-ATPase regulatory subunit 7 OS=Drosophila melanogaster GN=Rpn8 PE=1 SV=6 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- KOG1556 26S proteasome regulatory complex, subunit RPN8/PSMD7 Cluster-8309.40163 BF_2 362.08 5.65 2970 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40165 BF_2 295.00 1512.36 252 91087441 XP_975685.1 163 2.1e-09 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.40166 BF_2 144.00 38.79 442 91087441 XP_975685.1 238 7.2e-18 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27017 144 2.4e-08 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.40168 BF_2 29.60 0.45 3058 167234236 NP_001107808.1 1761 1.3e-193 GABA receptor isoform a precursor [Tribolium castaneum]>gi|156447603|gb|ABU63594.1| GABA-gated anion channel splice variant 3a6a [Tribolium castaneum] 411147304 AB697765.1 549 0 Oulema oryzae OoRdl mRNA for GABA-gated chloride channel, complete cds K05195 GLRA3 glycine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K05195 Q75NA5 1521 3.5e-167 Gamma-aminobutyric acid receptor subunit beta OS=Musca domestica GN=Rdl PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006821//GO:0007214//GO:0006811 transport//chloride transport//gamma-aminobutyric acid signaling pathway//ion transport GO:0004890//GO:0005230 GABA-A receptor activity//extracellular ligand-gated ion channel activity GO:0005886//GO:0016021//GO:0016020//GO:0030054//GO:0045211 plasma membrane//integral component of membrane//membrane//cell junction//postsynaptic membrane -- -- Cluster-8309.40170 BF_2 42.44 1.28 1669 -- -- -- -- -- 642914349 XM_008203421.1 47 5.58865e-13 PREDICTED: Tribolium castaneum inhibitor of apoptosis 1 (LOC663941), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40171 BF_2 5074.75 71.72 3247 546685733 ERL95188.1 972 4.1e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 2.7e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.40172 BF_2 2583.20 603.31 466 270005418 EFA01866.1 440 2.9e-41 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] 642919750 XM_008193828.1 48 4.1202e-14 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 Q5R4D4 294 1.0e-25 Nucleosome assembly protein 1-like 1 OS=Pongo abelii GN=NAP1L1 PE=2 SV=1 PF00956 Nucleosome assembly protein (NAP) GO:0006334 nucleosome assembly -- -- GO:0005634 nucleus KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.40173 BF_2 1634.10 32.58 2385 478252477 ENN72899.1 961 5.7e-101 hypothetical protein YQE_10469, partial [Dendroctonus ponderosae]>gi|546682597|gb|ERL92516.1| hypothetical protein D910_09829 [Dendroctonus ponderosae] 642923699 XM_008195626.1 122 1.6325e-54 PREDICTED: Tribolium castaneum uncharacterized LOC103313143 (LOC103313143), mRNA -- -- -- -- Q66IT9 149 3.4e-08 Immediate early response gene 5-like protein OS=Xenopus laevis GN=ier5l PE=2 SV=2 PF07557//PF09726 Shugoshin C terminus//Transmembrane protein GO:0045132 meiotic chromosome segregation -- -- GO:0005634//GO:0000775//GO:0016021 nucleus//chromosome, centromeric region//integral component of membrane -- -- Cluster-8309.40174 BF_2 13.47 0.63 1178 642939241 XP_008194774.1 1159 3.1e-124 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q4JM44 411 6.9e-39 Phosphatidylcholine:ceramide cholinephosphotransferase 2 OS=Rattus norvegicus GN=Sgms2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.40176 BF_2 84.46 1.71 2351 282165792 NP_001164135.1 593 2.6e-58 drongo protein isoform 2 [Tribolium castaneum]>gi|270008252|gb|EFA04700.1| drongo [Tribolium castaneum] -- -- -- -- -- K15044 AGFG1 Arf-GAP domain and FG repeats-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15044 O95081 224 6.7e-17 Arf-GAP domain and FG repeat-containing protein 2 OS=Homo sapiens GN=AGFG2 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0702 Predicted GTPase-activating protein Cluster-8309.40177 BF_2 60.44 0.84 3315 270011248 EFA07696.1 495 8.6e-47 hypothetical protein TcasGA2_TC002172 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40179 BF_2 516.41 8.33 2879 642913258 XP_008201460.1 819 2.0e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 175 6.80593e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.3e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40181 BF_2 284.07 2.92 4354 642912272 XP_008200632.1 422 3.3e-38 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P6T1 164 1.1e-09 Complement C1s subcomponent OS=Rattus norvegicus GN=C1s PE=2 SV=2 PF01414//PF00089//PF15965//PF04625 Delta serrate ligand//Trypsin//TRAF-like zinc-finger//DEC-1 protein, N-terminal region GO:0007154//GO:0007304//GO:0006508 cell communication//chorion-containing eggshell formation//proteolysis GO:0005213//GO:0004252//GO:0008270 structural constituent of chorion//serine-type endopeptidase activity//zinc ion binding GO:0042600//GO:0016020//GO:0005576 chorion//membrane//extracellular region -- -- Cluster-8309.40182 BF_2 1785.00 13.77 5708 815925257 XP_012247265.1 1507 6.6e-164 PREDICTED: mucin-17 isoform X1 [Bombus impatiens]>gi|815925259|ref|XP_012247266.1| PREDICTED: mucin-17 isoform X1 [Bombus impatiens] 687869355 LK939485.1 58 1.48864e-18 Angiostrongylus costaricensis genome assembly A_costaricensis_Costa_Rica ,scaffold ACOC_scaffold0000311 K08867 WNK, PRKWNK WNK lysine deficient protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08867 Q9BYP7 1238 4.3e-134 Serine/threonine-protein kinase WNK3 OS=Homo sapiens GN=WNK3 PE=1 SV=3 PF05454//PF05434//PF00069//PF07714//PF12202 Dystroglycan (Dystrophin-associated glycoprotein 1)//TMEM9//Protein kinase domain//Protein tyrosine kinase//Oxidative-stress-responsive kinase 1 C terminal GO:0006468//GO:0009069//GO:0016310//GO:0007016 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//cytoskeletal anchoring at plasma membrane GO:0004674//GO:0004672//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016010//GO:0016021 dystrophin-associated glycoprotein complex//integral component of membrane KOG0584 Serine/threonine protein kinase Cluster-8309.40183 BF_2 91.90 2.48 1835 546674232 ERL85660.1 317 2.1e-26 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40185 BF_2 192.30 0.80 10301 91090496 XP_969212.1 1701 3.8e-186 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] 642935356 XM_964189.2 200 3.11077e-97 PREDICTED: Tribolium castaneum forkhead box protein P4 (LOC657747), mRNA K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 1044 2.4e-111 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF01546//PF00250//PF01299 Peptidase family M20/M25/M40//Forkhead domain//Lysosome-associated membrane glycoprotein (Lamp) GO:0006508//GO:0006355//GO:0006520//GO:0008152//GO:0000051 proteolysis//regulation of transcription, DNA-templated//cellular amino acid metabolic process//metabolic process//obsolete urea cycle intermediate metabolic process GO:0008237//GO:0043565//GO:0003700//GO:0016787//GO:0004046 metallopeptidase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//hydrolase activity//aminoacylase activity GO:0016020//GO:0005737//GO:0005667 membrane//cytoplasm//transcription factor complex KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.40188 BF_2 138.70 1.14 5381 642921494 XP_968130.3 3680 0.0e+00 PREDICTED: uncharacterized protein LOC656511 [Tribolium castaneum]>gi|270006226|gb|EFA02674.1| hypothetical protein TcasGA2_TC008395 [Tribolium castaneum] 642921493 XM_963037.3 224 7.38089e-111 PREDICTED: Tribolium castaneum uncharacterized LOC656511 (LOC656511), mRNA -- -- -- -- O43182 480 3.2e-46 Rho GTPase-activating protein 6 OS=Homo sapiens GN=ARHGAP6 PE=1 SV=3 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG2710 Rho GTPase-activating protein Cluster-8309.40189 BF_2 30.67 0.61 2375 642910653 XP_968714.2 302 1.5e-24 PREDICTED: polyadenylate-binding protein-interacting protein 2B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40191 BF_2 1400.53 5.57 10807 546678137 ERL88846.1 5650 0.0e+00 hypothetical protein D910_06228 [Dendroctonus ponderosae] 645022822 XM_008219359.1 125 1.60708e-55 PREDICTED: Nasonia vitripennis glycogen debranching enzyme (LOC100117168), transcript variant X9, mRNA K01196 AGL glycogen debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01196 P35573 3921 0.0e+00 Glycogen debranching enzyme OS=Homo sapiens GN=AGL PE=1 SV=3 PF09162//PF04043//PF07714//PF00069//PF01059 Tap, RNA-binding//Plant invertase/pectin methylesterase inhibitor//Protein tyrosine kinase//Protein kinase domain//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006406//GO:0006468//GO:0006120//GO:0055114 mRNA export from nucleus//protein phosphorylation//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process GO:0004857//GO:0005524//GO:0003723//GO:0004672 enzyme inhibitor activity//ATP binding//RNA binding//protein kinase activity GO:0005634//GO:0005737 nucleus//cytoplasm KOG3625 Alpha amylase Cluster-8309.40192 BF_2 27.30 0.32 3898 642928027 XP_008200126.1 2655 3.5e-297 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.64955e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 1139 8.8e-123 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF00038//PF02601//PF03836//PF01920//PF10174//PF00435//PF13202//PF00769//PF00036//PF12763//PF01576//PF10186//PF04111//PF13405//PF13833//PF13499 Intermediate filament protein//Exonuclease VII, large subunit//RasGAP C-terminus//Prefoldin subunit//RIM-binding protein of the cytomatrix active zone//Spectrin repeat//EF hand//Ezrin/radixin/moesin family//EF hand//Cytoskeletal-regulatory complex EF hand//Myosin tail//Vacuolar sorting 38 and autophagy-related subunit 14//Autophagy protein Apg6//EF-hand domain//EF-hand domain pair//EF-hand domain pair GO:0006457//GO:0007264//GO:0006308//GO:0006914//GO:0010508 protein folding//small GTPase mediated signal transduction//DNA catabolic process//autophagy//positive regulation of autophagy GO:0008092//GO:0005515//GO:0008855//GO:0003774//GO:0005509//GO:0005096//GO:0005198//GO:0051082 cytoskeletal protein binding//protein binding//exodeoxyribonuclease VII activity//motor activity//calcium ion binding//GTPase activator activity//structural molecule activity//unfolded protein binding GO:0016459//GO:0019898//GO:0005882//GO:0009318//GO:0048786//GO:0005737//GO:0016272 myosin complex//extrinsic component of membrane//intermediate filament//exodeoxyribonuclease VII complex//presynaptic active zone//cytoplasm//prefoldin complex KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.40193 BF_2 272.72 19.85 862 91080601 XP_974038.1 861 8.1e-90 PREDICTED: mediator of RNA polymerase II transcription subunit 7 [Tribolium castaneum]>gi|270005511|gb|EFA01959.1| hypothetical protein TcasGA2_TC007575 [Tribolium castaneum] -- -- -- -- -- K15148 MED7 mediator of RNA polymerase II transcription subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15148 Q7PR68 598 1.0e-60 Mediator of RNA polymerase II transcription subunit 7 OS=Anopheles gambiae GN=MED7 PE=3 SV=2 PF00042//PF05983 Globin//MED7 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0020037//GO:0019825//GO:0001104 heme binding//oxygen binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG0570 Transcriptional coactivator Cluster-8309.40195 BF_2 3050.00 27.13 4990 646622486 KDQ71473.1 2274 6.7e-253 Propionyl-CoA carboxylase beta chain, mitochondrial [Zootermopsis nevadensis] 645005303 XR_513193.1 192 4.20551e-93 PREDICTED: Nasonia vitripennis probable serine/threonine-protein kinase dyrk2 (LOC100121588), transcript variant X2, misc_RNA K01966 PCCB, pccB propionyl-CoA carboxylase beta chain http://www.genome.jp/dbget-bin/www_bget?ko:K01966 P79384 2028 9.2e-226 Propionyl-CoA carboxylase beta chain, mitochondrial OS=Sus scrofa GN=PCCB PE=2 SV=1 PF12632//PF00608//PF06833//PF07714//PF00069 Mysoin-binding motif of peroxisomes//Adenoviral fibre protein (repeat/shaft region)//Malonate decarboxylase gamma subunit (MdcE)//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009405//GO:0019062//GO:0007155 protein phosphorylation//pathogenesis//virion attachment to host cell//cell adhesion GO:0016874//GO:0005524//GO:0004672//GO:0017022 ligase activity//ATP binding//protein kinase activity//myosin binding GO:0016459 myosin complex KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.40201 BF_2 210.83 7.37 1484 644997797 XP_008212003.1 387 1.3e-34 PREDICTED: putative fatty acyl-CoA reductase CG5065 isoform X2 [Nasonia vitripennis]>gi|644997799|ref|XP_008212004.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 isoform X2 [Nasonia vitripennis] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 272 1.1e-22 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.40202 BF_2 257.12 7.09 1804 91078442 XP_966794.1 1592 2.9e-174 PREDICTED: prolactin-releasing peptide receptor [Tribolium castaneum]>gi|270004854|gb|EFA01302.1| hypothetical protein TcasGA2_TC003151 [Tribolium castaneum] 194748027 XM_001956415.1 65 5.96538e-23 Drosophila ananassae GF25215 (Dana\GF25215), mRNA K04209 NPYNR neuropeptide Y receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K04209 Q5IS62 505 1.3e-49 Neuropeptide Y receptor type 2 OS=Pan troglodytes GN=NPY2R PE=2 SV=1 PF03600//PF06072//PF00001 Citrate transporter//Alphaherpesvirus tegument protein US9//7 transmembrane receptor (rhodopsin family) GO:0007268//GO:0007187//GO:0055085//GO:0007186 synaptic transmission//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004983//GO:0004930 neuropeptide Y receptor activity//G-protein coupled receptor activity GO:0019033//GO:0016021 viral tegument//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.40203 BF_2 583.37 27.90 1162 642919254 XP_008191795.1 1574 2.3e-172 PREDICTED: uncharacterized protein C05D11.7 isoform X1 [Tribolium castaneum] 569534448 KF724681.1 127 1.30084e-57 Manduca sexta adipose triglyceride lipase mRNA, complete cds K16816 PNPLA2, ATGL patatin-like phospholipase domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16816 Q8BJ56 695 8.0e-72 Patatin-like phospholipase domain-containing protein 2 OS=Mus musculus GN=Pnpla2 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG3773 Adiponutrin and related vesicular transport proteins; predicted alpha/beta hydrolase Cluster-8309.40204 BF_2 304.00 13.96 1198 642911124 XP_008200590.1 697 1.2e-70 PREDICTED: peflin [Tribolium castaneum]>gi|270014674|gb|EFA11122.1| hypothetical protein TcasGA2_TC004722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UBV8 373 1.8e-34 Peflin OS=Homo sapiens GN=PEF1 PE=1 SV=1 PF13202//PF13833//PF13405//PF00036//PF13499 EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.40205 BF_2 216.25 7.00 1580 91093244 XP_969150.1 1801 1.5e-198 PREDICTED: methionine aminopeptidase 2 [Tribolium castaneum]>gi|270016683|gb|EFA13129.1| hypothetical protein TcasGA2_TC006844 [Tribolium castaneum] 765160084 XM_004083214.2 204 2.80004e-100 PREDICTED: Oryzias latipes methionyl aminopeptidase 2 (metap2), mRNA K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 P38062 1488 1.2e-163 Methionine aminopeptidase 2 OS=Rattus norvegicus GN=Metap2 PE=1 SV=2 PF03839//PF02724 Translocation protein Sec62//CDC45-like protein GO:0009987//GO:0015031//GO:0006508//GO:0006270 cellular process//protein transport//proteolysis//DNA replication initiation GO:0046872//GO:0008235//GO:0004177//GO:0008565 metal ion binding//metalloexopeptidase activity//aminopeptidase activity//protein transporter activity GO:0016021 integral component of membrane KOG2775 Metallopeptidase Cluster-8309.40206 BF_2 16.59 0.39 2075 646705165 KDR13032.1 774 2.4e-79 Ras-like protein 3 [Zootermopsis nevadensis] 642938605 XM_008201640.1 231 3.6195e-115 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 751 4.6e-78 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF08477//PF03193//PF01926//PF00503//PF00071//PF00025//PF00910 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//G-protein alpha subunit//Ras family//ADP-ribosylation factor family//RNA helicase GO:0007186//GO:0007264//GO:0007165 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//signal transduction GO:0004871//GO:0019001//GO:0005525//GO:0003724//GO:0031683//GO:0003723//GO:0003924 signal transducer activity//guanyl nucleotide binding//GTP binding//RNA helicase activity//G-protein beta/gamma-subunit complex binding//RNA binding//GTPase activity -- -- KOG0395 Ras-related GTPase Cluster-8309.40207 BF_2 720.74 8.54 3816 512892422 XP_004922927.1 1127 5.1e-120 PREDICTED: uncharacterized protein LOC101739908 [Bombyx mori] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 468 5.5e-45 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.40208 BF_2 418.58 17.22 1304 642912068 XP_008200785.1 780 3.0e-80 PREDICTED: peroxidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 455 6.0e-44 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.40209 BF_2 2117.34 38.48 2589 531444638 AGT57836.1 1107 7.3e-118 cytochrome P450 412a1 [Leptinotarsa decemlineata] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 785 6.5e-82 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF01105//PF00067 emp24/gp25L/p24 family/GOLD//Cytochrome P450 GO:0055114//GO:0006810 oxidation-reduction process//transport GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016021 integral component of membrane -- -- Cluster-8309.40210 BF_2 11.16 0.43 1380 546685590 ERL95077.1 425 4.7e-39 hypothetical protein D910_12347 [Dendroctonus ponderosae] 658887074 XM_008428179.1 114 2.61627e-50 PREDICTED: Poecilia reticulata clathrin, heavy chain (Hc) (cltc), transcript variant X4, mRNA K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P29742 373 2.1e-34 Clathrin heavy chain OS=Drosophila melanogaster GN=Chc PE=1 SV=1 PF00637 Region in Clathrin and VPS GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport -- -- -- -- KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.40211 BF_2 49.22 1.21 1990 546678419 ERL89042.1 288 5.2e-23 hypothetical protein D910_06420 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1ZB86 173 4.6e-11 Kelch domain-containing protein 10 homolog OS=Drosophila melanogaster GN=slim PE=1 SV=1 PF01344//PF07646 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40212 BF_2 9.99 0.59 1001 91078162 XP_966448.1 459 3.9e-43 PREDICTED: 60S ribosomal protein L24 [Tribolium castaneum]>gi|270001366|gb|EEZ97813.1| hypothetical protein TcasGA2_TC000180 [Tribolium castaneum] 40642995 AJ563459.1 43 5.53612e-11 Crassostrea gigas partial mRNA for ribosomal protein L24 (rpl24 gene) K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q6F444 423 2.4e-40 60S ribosomal protein L24 OS=Plutella xylostella GN=RpL24 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1722 60s ribosomal protein L24 Cluster-8309.40213 BF_2 2036.07 25.16 3673 332374310 AEE62296.1 1023 5.7e-108 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 474 1.1e-45 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF01353 Green fluorescent protein GO:0008218 bioluminescence -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.40214 BF_2 858.55 5.56 6745 572308871 XP_006620242.1 1074 1.3e-113 PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X1 [Apis dorsata]>gi|572308873|ref|XP_006620243.1| PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X2 [Apis dorsata] 837814424 XM_012928152.1 259 3.23761e-130 PREDICTED: Ochotona princeps ribose-phosphate pyrophosphokinase 1 (LOC101518950), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 Q2HJ58 1002 1.2e-106 Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus GN=PRPS1 PE=2 SV=3 PF14572//PF00160//PF00156 Phosphoribosyl synthetase-associated domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Phosphoribosyl transferase domain GO:0009165//GO:0006144//GO:0006457//GO:0006098//GO:0000413//GO:0009116 nucleotide biosynthetic process//purine nucleobase metabolic process//protein folding//pentose-phosphate shunt//protein peptidyl-prolyl isomerization//nucleoside metabolic process GO:0000287//GO:0004749//GO:0003755 magnesium ion binding//ribose phosphate diphosphokinase activity//peptidyl-prolyl cis-trans isomerase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.40215 BF_2 1030.00 46.74 1209 817011233 AKF11870.1 880 7.1e-92 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 617 9.2e-63 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.40216 BF_2 460.52 7.15 2980 820805524 AKG92753.1 1314 8.3e-142 mnt1 [Leptinotarsa decemlineata] -- -- -- -- -- K09115 MNT, ROX MAX-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K09115 O08789 363 6.4e-33 Max-binding protein MNT OS=Mus musculus GN=Mnt PE=2 SV=2 PF04111//PF00010 Autophagy protein Apg6//Helix-loop-helix DNA-binding domain GO:0006914 autophagy GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.40218 BF_2 27.08 0.37 3357 91089503 XP_970142.1 705 3.9e-71 PREDICTED: chloride intracellular channel exc-4 [Tribolium castaneum]>gi|270011391|gb|EFA07839.1| hypothetical protein TcasGA2_TC005408 [Tribolium castaneum] 642933335 XM_965049.3 167 2.22615e-79 PREDICTED: Tribolium castaneum chloride intracellular channel exc-4 (LOC658685), mRNA -- -- -- -- Q8WQA4 290 2.1e-24 Chloride intracellular channel exc-4 OS=Caenorhabditis elegans GN=exc-4 PE=1 SV=2 PF02798 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG1422 Intracellular Cl- channel CLIC, contains GST domain Cluster-8309.40219 BF_2 20.55 2.24 670 507228 AAA64736.1 285 3.9e-23 apolipophorin-III, partial [Derobrachus geminatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07464//PF05531//PF01474 Apolipophorin-III precursor (apoLp-III)//Nucleopolyhedrovirus P10 protein//Class-II DAHP synthetase family GO:0009094//GO:0009073//GO:0006571//GO:0000162//GO:0006869 L-phenylalanine biosynthetic process//aromatic amino acid family biosynthetic process//tyrosine biosynthetic process//tryptophan biosynthetic process//lipid transport GO:0003849//GO:0008289 3-deoxy-7-phosphoheptulonate synthase activity//lipid binding GO:0005576//GO:0019028 extracellular region//viral capsid -- -- Cluster-8309.40221 BF_2 1593.71 8.97 7722 642913878 XP_975183.2 7115 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X1 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.50454e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q96C24 760 1.5e-78 Synaptotagmin-like protein 4 OS=Homo sapiens GN=SYTL4 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.40223 BF_2 1296.68 19.92 3010 642921186 XP_008192751.1 888 2.1e-92 PREDICTED: reticulon-1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7MC64 482 1.0e-46 Reticulon-1 OS=Xenopus tropicalis GN=rtn1 PE=2 SV=2 PF00834//PF01442 Ribulose-phosphate 3 epimerase family//Apolipoprotein A1/A4/E domain GO:0042157//GO:0005975//GO:0006869 lipoprotein metabolic process//carbohydrate metabolic process//lipid transport GO:0016857//GO:0008289 racemase and epimerase activity, acting on carbohydrates and derivatives//lipid binding GO:0005576 extracellular region KOG1792 Reticulon Cluster-8309.40224 BF_2 4.52 0.33 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40226 BF_2 431.72 1.62 11412 642910658 XP_008200046.1 10447 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.40227 BF_2 565.78 5.08 4950 270013506 EFA09954.1 2607 1.6e-291 hypothetical protein TcasGA2_TC012107 [Tribolium castaneum] 768421079 XM_011553033.1 246 3.99819e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 2129 1.8e-237 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00858//PF04147//PF00069//PF07714//PF00433//PF00628//PF00130 Amiloride-sensitive sodium channel//Nop14-like family//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006814//GO:0035556//GO:0016310//GO:0006468//GO:0009069 sodium ion transport//intracellular signal transduction//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005272//GO:0005524//GO:0005515 protein kinase activity//protein serine/threonine kinase activity//sodium channel activity//ATP binding//protein binding GO:0016020//GO:0032040 membrane//small-subunit processome KOG0694 Serine/threonine protein kinase Cluster-8309.40228 BF_2 6267.38 37.73 7236 642934549 XP_008197710.1 1880 4.7e-207 PREDICTED: axoneme-associated protein mst101(2)-like isoform X2 [Tribolium castaneum] 768421079 XM_011553033.1 246 5.8555e-123 PREDICTED: Plutella xylostella serine/threonine-protein kinase STE20-like (LOC105383024), transcript variant X3, mRNA K06068 PRKCD novel protein kinase C delta type http://www.genome.jp/dbget-bin/www_bget?ko:K06068 P83099 1473 3.0e-161 Putative protein kinase C delta type homolog OS=Drosophila melanogaster GN=Pkcdelta PE=2 SV=3 PF00858//PF00069//PF07714//PF00433 Amiloride-sensitive sodium channel//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain GO:0006814//GO:0016310//GO:0006468//GO:0009069 sodium ion transport//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005272//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//sodium channel activity//ATP binding GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.40229 BF_2 67.71 0.95 3279 646696804 KDR08844.1 4269 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component [Zootermopsis nevadensis] 642930974 XM_008197940.1 1005 0 PREDICTED: Tribolium castaneum 116 kDa U5 small nuclear ribonucleoprotein component (LOC661338), mRNA K12852 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component http://www.genome.jp/dbget-bin/www_bget?ko:K12852 Q5F3X4 3877 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component OS=Gallus gallus GN=EFTUD2 PE=2 SV=1 PF03764//PF00071//PF08477//PF03144//PF01926 Elongation factor G, domain IV//Ras family//Ras of Complex, Roc, domain of DAPkinase//Elongation factor Tu domain 2//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0468 U5 snRNP-specific protein Cluster-8309.40230 BF_2 1618.58 55.42 1509 642929019 XP_008195657.1 681 1.1e-68 PREDICTED: uncharacterized protein LOC662417 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P01042 137 5.2e-07 Kininogen-1 OS=Homo sapiens GN=KNG1 PE=1 SV=2 PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.40231 BF_2 597.06 6.45 4157 642924110 XP_008194009.1 2499 4.5e-279 PREDICTED: serine/threonine-protein kinase mig-15 isoform X5 [Tribolium castaneum] 642924109 XM_008195787.1 606 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1483 1.2e-162 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.40235 BF_2 1785.82 21.52 3759 642933896 XP_971172.2 2710 1.4e-303 PREDICTED: dual specificity testis-specific protein kinase 2 [Tribolium castaneum] 642933895 XM_966079.3 363 0 PREDICTED: Tribolium castaneum dual specificity testis-specific protein kinase 2 (LOC659807), mRNA K08842 TESK2 testis-specific kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08842 Q96S53 914 1.0e-96 Dual specificity testis-specific protein kinase 2 OS=Homo sapiens GN=TESK2 PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.40236 BF_2 2449.89 20.96 5177 668462939 KFB50382.1 1452 1.4e-157 AGAP005306-PA-like protein [Anopheles sinensis] 751770441 XM_011201182.1 332 6.52138e-171 PREDICTED: Bactrocera dorsalis calcium/calmodulin-dependent protein kinase type 1 (LOC105223446), mRNA K08794 CAMK1 calcium/calmodulin-dependent protein kinase I http://www.genome.jp/dbget-bin/www_bget?ko:K08794 Q9TXJ0 1242 1.3e-134 Calcium/calmodulin-dependent protein kinase type 1 OS=Caenorhabditis elegans GN=cmk-1 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.40237 BF_2 34.36 0.35 4430 91094045 XP_968644.1 1387 4.2e-150 PREDICTED: RNA-binding protein 12 [Tribolium castaneum]>gi|270003124|gb|EEZ99571.1| hypothetical protein TcasGA2_TC001555 [Tribolium castaneum] -- -- -- -- -- K08331 ATG13 autophagy-related protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08331 Q9VHR6 650 5.0e-66 Autophagy-related protein 13 homolog OS=Drosophila melanogaster GN=Atg13 PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG3874 Uncharacterized conserved protein Cluster-8309.40238 BF_2 36.84 0.71 2461 642914939 XP_008190450.1 877 3.2e-91 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q1LXK4 378 9.7e-35 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF00301 Rubredoxin -- -- GO:0005506 iron ion binding -- -- KOG1804 RNA helicase Cluster-8309.40239 BF_2 446.41 7.50 2778 817053730 XP_012263556.1 971 4.6e-102 PREDICTED: tafazzin homolog [Athalia rosae] -- -- -- -- -- K13511 TAZ monolysocardiolipin acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13511 Q9V6G5 816 1.8e-85 Tafazzin homolog OS=Drosophila melanogaster GN=Taz PE=2 SV=2 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG2847 Phosphate acyltransferase Cluster-8309.40240 BF_2 30.00 0.56 2539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40241 BF_2 1891.73 129.55 898 546681509 ERL91586.1 436 1.6e-40 hypothetical protein D910_08916 [Dendroctonus ponderosae] -- -- -- -- -- K12160 SUMO, SMT3 small ubiquitin-related modifier http://www.genome.jp/dbget-bin/www_bget?ko:K12160 Q6NV25 328 2.2e-29 Small ubiquitin-related modifier 3-like OS=Danio rerio GN=sumo3l PE=3 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG1769 Ubiquitin-like proteins Cluster-8309.40242 BF_2 2180.54 58.44 1848 332374554 AEE62418.1 1390 7.9e-151 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 853 6.1e-90 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.40246 BF_2 147.91 1.99 3404 642930288 XP_008196330.1 3568 0.0e+00 PREDICTED: semaphorin-1A isoform X1 [Tribolium castaneum] 642930289 XM_008198109.1 795 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2578 1.1e-289 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF05700//PF01437//PF01403 Breast carcinoma amplified sequence 2 (BCAS2)//Plexin repeat//Sema domain GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.40248 BF_2 11.72 0.58 1134 270010353 EFA06801.1 477 3.6e-45 hypothetical protein TcasGA2_TC009740 [Tribolium castaneum] -- -- -- -- -- K02090 CDK5 cyclin-dependent kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02090 Q00535 310 3.4e-27 Cyclin-dependent-like kinase 5 OS=Homo sapiens GN=CDK5 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0662 Cyclin-dependent kinase CDK5 Cluster-8309.40249 BF_2 476.87 6.48 3366 91086569 XP_973078.1 1429 4.3e-155 PREDICTED: E3 ubiquitin-protein ligase AMFR-like [Tribolium castaneum] -- -- -- -- -- K10636 AMFR, GP78 autocrine motility factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10636 Q9UKV5 826 1.5e-86 E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR PE=1 SV=2 PF17122//PF00097//PF17123//PF12906//PF12678//PF14634//PF13639//PF02845//PF12861 Zinc-finger//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger//zinc-RING finger domain//Ring finger domain//CUE domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.40251 BF_2 271.29 3.10 3947 546676985 ERL87909.1 599 8.9e-59 hypothetical protein D910_05297 [Dendroctonus ponderosae] -- -- -- -- -- K13208 ELAVL2_3_4 ELAV like protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13208 O61374 367 2.9e-33 Sex-lethal homolog OS=Ceratitis capitata GN=SXL PE=2 SV=2 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.40252 BF_2 35.87 11.07 422 478252124 ENN72555.1 292 3.8e-24 hypothetical protein YQE_10895, partial [Dendroctonus ponderosae] -- -- -- -- -- K18747 SXL protein sex-lethal http://www.genome.jp/dbget-bin/www_bget?ko:K18747 Q15717 170 2.2e-11 ELAV-like protein 1 OS=Homo sapiens GN=ELAVL1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.40253 BF_2 2071.42 12.92 6994 189239891 XP_969420.2 5035 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Tribolium castaneum] 752863719 XM_011269923.1 157 1.68866e-73 PREDICTED: Camponotus floridanus E3 ubiquitin-protein ligase UBR3 (LOC105258579), mRNA K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 1245 8.1e-135 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF02323//PF13639//PF00643//PF02207 Egg-laying hormone precursor//Ring finger domain//B-box zinc finger//Putative zinc finger in N-recognin (UBR box) GO:0007165//GO:0007275 signal transduction//multicellular organismal development GO:0008270//GO:0005179//GO:0005515 zinc ion binding//hormone activity//protein binding GO:0005576//GO:0005622 extracellular region//intracellular KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.40254 BF_2 1009.31 6.17 7126 189239891 XP_969420.2 6439 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Tribolium castaneum] 752863719 XM_011269923.1 159 1.33018e-74 PREDICTED: Camponotus floridanus E3 ubiquitin-protein ligase UBR3 (LOC105258579), mRNA K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 1589 1.1e-174 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF02323//PF13639//PF02207 Egg-laying hormone precursor//Ring finger domain//Putative zinc finger in N-recognin (UBR box) GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0008270//GO:0005515//GO:0005179 zinc ion binding//protein binding//hormone activity GO:0005576 extracellular region KOG1139 Predicted ubiquitin-protein ligase of the N-recognin family Cluster-8309.40258 BF_2 395.00 19.70 1126 91087153 XP_975332.1 608 2.3e-60 PREDICTED: 28S ribosomal protein S11, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02948 RP-S11, MRPS11, rpsK small subunit ribosomal protein S11 http://www.genome.jp/dbget-bin/www_bget?ko:K02948 P82911 252 1.8e-20 28S ribosomal protein S11, mitochondrial OS=Bos taurus GN=MRPS11 PE=1 SV=2 PF00411 Ribosomal protein S11 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0408 Mitochondrial/chloroplast ribosomal protein S11 Cluster-8309.40259 BF_2 94.76 0.45 9136 91082383 XP_968748.1 3389 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.44699e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2467 2.1e-276 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF03266//PF01637//PF06414//PF02367//PF01580//PF00931//PF00664//PF13304//PF00158//PF01926//PF00437 ABC transporter//Protein of unknown function, DUF258//NTPase//Archaeal ATPase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//FtsK/SpoIIIE family//NB-ARC domain//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Sigma-54 interaction domain//50S ribosome-binding GTPase//Type II/IV secretion system protein GO:0006810//GO:0055085//GO:0006355//GO:0002949 transport//transmembrane transport//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0003924//GO:0098519//GO:0005524//GO:0042626//GO:0016301//GO:0016887//GO:0000166//GO:0043531//GO:0003677//GO:0017111//GO:0005525 transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//nucleotide binding//ADP binding//DNA binding//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.40260 BF_2 388.41 3.21 5349 642915646 XP_008190694.1 3138 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.2e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.40261 BF_2 188.96 2.75 3161 260800283 XP_002595063.1 737 7.1e-75 hypothetical protein BRAFLDRAFT_115226 [Branchiostoma floridae]>gi|229280305|gb|EEN51074.1| hypothetical protein BRAFLDRAFT_115226 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17038 695 2.2e-71 Zinc finger protein 43 OS=Homo sapiens GN=ZNF43 PE=2 SV=4 PF00096//PF13465//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40264 BF_2 557.16 11.10 2387 91077292 XP_974520.1 2379 2.1e-265 PREDICTED: splicing factor 3A subunit 3 [Tribolium castaneum]>gi|270002083|gb|EEZ98530.1| hypothetical protein TcasGA2_TC001034 [Tribolium castaneum] 242011600 XM_002426492.1 125 3.51181e-56 Pediculus humanus corporis Splicing factor 3A subunit, putative, mRNA K12827 SF3A3, SAP61, PRP9 splicing factor 3A subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12827 Q12874 1856 3.9e-206 Splicing factor 3A subunit 3 OS=Homo sapiens GN=SF3A3 PE=1 SV=1 PF06936 Selenoprotein S (SelS) GO:0006886 intracellular protein transport GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG2636 Splicing factor 3a, subunit 3 Cluster-8309.40267 BF_2 127.18 5.15 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40271 BF_2 1556.80 10.03 6780 91088351 XP_971536.1 3641 0.0e+00 PREDICTED: ER degradation-enhancing alpha-mannosidase-like protein 3 [Tribolium castaneum] 642931619 XM_966443.2 359 0 PREDICTED: Tribolium castaneum ER degradation-enhancing alpha-mannosidase-like protein 3 (LOC660189), mRNA K10086 EDEM3 ER degradation enhancer, mannosidase alpha-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10086 Q9BZQ6 2083 5.3e-232 ER degradation-enhancing alpha-mannosidase-like protein 3 OS=Homo sapiens GN=EDEM3 PE=1 SV=2 PF06662//PF00755//PF01532 D-glucuronyl C5-epimerase C-terminus//Choline/Carnitine o-acyltransferase//Glycosyl hydrolase family 47 GO:0005975//GO:0006024 carbohydrate metabolic process//glycosaminoglycan biosynthetic process GO:0005509//GO:0016857//GO:0004571//GO:0016746 calcium ion binding//racemase and epimerase activity, acting on carbohydrates and derivatives//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//transferase activity, transferring acyl groups GO:0016020//GO:0016021 membrane//integral component of membrane KOG2429 Glycosyl hydrolase, family 47 Cluster-8309.40272 BF_2 379.10 5.41 3216 478259304 ENN79206.1 1335 3.3e-144 hypothetical protein YQE_04390, partial [Dendroctonus ponderosae]>gi|546681746|gb|ERL91778.1| hypothetical protein D910_09104 [Dendroctonus ponderosae] 388519142 BT147839.1 36 1.41649e-06 Medicago truncatula clone JCVI-FLMt-9K12 unknown mRNA -- -- -- -- Q5R6C0 862 9.5e-91 Cell cycle control protein 50A OS=Pongo abelii GN=TMEM30A PE=2 SV=1 PF04103//PF03381 CD20-like family//LEM3 (ligand-effect modulator 3) family / CDC50 family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2952 Cell cycle control protein Cluster-8309.40273 BF_2 399.90 5.62 3264 478259304 ENN79206.1 1335 3.3e-144 hypothetical protein YQE_04390, partial [Dendroctonus ponderosae]>gi|546681746|gb|ERL91778.1| hypothetical protein D910_09104 [Dendroctonus ponderosae] 388519142 BT147839.1 36 1.43787e-06 Medicago truncatula clone JCVI-FLMt-9K12 unknown mRNA -- -- -- -- Q5R6C0 862 9.7e-91 Cell cycle control protein 50A OS=Pongo abelii GN=TMEM30A PE=2 SV=1 PF03381//PF04103 LEM3 (ligand-effect modulator 3) family / CDC50 family//CD20-like family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG2952 Cell cycle control protein Cluster-8309.40274 BF_2 48.84 0.39 5479 642930363 XP_008196367.1 971 9.1e-102 PREDICTED: protein DEK isoform X3 [Tribolium castaneum] 755904867 XM_005191748.2 95 3.86104e-39 PREDICTED: Musca domestica 40S ribosomal protein S20 (LOC101888042), mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.40276 BF_2 3.86 0.46 634 642912259 XP_008200626.1 301 5.1e-25 PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|642912261|ref|XP_008200627.1| PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|270002461|gb|EEZ98908.1| hypothetical protein TcasGA2_TC004527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40277 BF_2 659.21 1.94 14515 478258629 ENN78679.1 7005 0.0e+00 hypothetical protein YQE_04851, partial [Dendroctonus ponderosae]>gi|546685785|gb|ERL95234.1| hypothetical protein D910_12501 [Dendroctonus ponderosae] 665784642 XM_008562939.1 48 1.37592e-12 PREDICTED: Microplitis demolitor synaptobrevin homolog YKT6 (LOC103580980), mRNA K05732 GRLF1 glucocorticoid receptor DNA-binding factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05732 Q9VX32 2839 0.0e+00 Rho GTPase-activating protein 190 OS=Drosophila melanogaster GN=RhoGAPp190 PE=1 SV=2 PF00071//PF01207//PF10403//PF08911//PF00957//PF00642//PF00620 Ras family//Dihydrouridine synthase (Dus)//Rad4 beta-hairpin domain 1//NUP50 (Nucleoporin 50 kDa)//Synaptobrevin//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//RhoGAP domain GO:0016192//GO:0007165//GO:0008033//GO:0007264//GO:0055114 vesicle-mediated transport//signal transduction//tRNA processing//small GTPase mediated signal transduction//oxidation-reduction process GO:0017150//GO:0003677//GO:0046872//GO:0050660//GO:0005525 tRNA dihydrouridine synthase activity//DNA binding//metal ion binding//flavin adenine dinucleotide binding//GTP binding GO:0016021//GO:0005643 integral component of membrane//nuclear pore KOG2333 Uncharacterized conserved protein Cluster-8309.40279 BF_2 43.72 2.18 1126 642925244 XP_008194480.1 506 1.5e-48 PREDICTED: fatty acid synthase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49327 262 1.3e-21 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF00975//PF16093 Thioesterase domain//Proteasome assembly chaperone 4 GO:0043248//GO:0009058 proteasome assembly//biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.40280 BF_2 641.17 9.76 3034 642914511 XP_008201707.1 1442 1.2e-156 PREDICTED: protein scalloped isoform X2 [Tribolium castaneum] 642914510 XM_008203485.1 441 0 PREDICTED: Tribolium castaneum scalloped (LOC658922), transcript variant X2, mRNA K09448 TEAD transcriptional enhancer factor http://www.genome.jp/dbget-bin/www_bget?ko:K09448 P28347 1085 1.2e-116 Transcriptional enhancer factor TEF-1 OS=Homo sapiens GN=TEAD1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3841 TEF-1 and related transcription factor, TEAD family Cluster-8309.40281 BF_2 117.76 2.08 2654 728417098 AIY68333.1 930 2.5e-97 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 555 3.1e-55 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.40282 BF_2 570.10 4.58 5490 283046718 NP_001164305.1 2081 1.8e-230 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial [Tribolium castaneum]>gi|270008216|gb|EFA04664.1| hypothetical protein TcasGA2_TC014119 [Tribolium castaneum] 332373615 BT126987.1 432 0 Dendroctonus ponderosae clone DPO013_P18 unknown mRNA K03942 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03942 Q91YT0 1897 1.6e-210 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Mus musculus GN=Ndufv1 PE=1 SV=1 PF04177//PF10589 TAP42-like family//NADH-ubiquinone oxidoreductase-F iron-sulfur binding region GO:0006120//GO:0009966//GO:0006744//GO:0006814//GO:0015992//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//regulation of signal transduction//ubiquinone biosynthetic process//sodium ion transport//proton transport//oxidation-reduction process GO:0010181//GO:0051287//GO:0008137//GO:0051539 FMN binding//NAD binding//NADH dehydrogenase (ubiquinone) activity//4 iron, 4 sulfur cluster binding -- -- KOG2658 NADH:ubiquinone oxidoreductase, NDUFV1/51kDa subunit Cluster-8309.40283 BF_2 2552.53 65.68 1913 91080775 XP_968281.1 1628 2.1e-178 PREDICTED: rab GDP dissociation inhibitor alpha [Tribolium castaneum]>gi|270005439|gb|EFA01887.1| hypothetical protein TcasGA2_TC007497 [Tribolium castaneum] 299756048 XM_001829008.2 37 2.32659e-07 Coprinopsis cinerea okayama7#130 ### RAB GDP-dissociation inhibitor, mRNA K17255 GDI1_2 Rab GDP dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K17255 Q7YQM0 1125 1.8e-121 Rab GDP dissociation inhibitor alpha OS=Pongo pygmaeus GN=GDI1 PE=2 SV=1 -- -- GO:0015031 protein transport GO:0005093 Rab GDP-dissociation inhibitor activity -- -- KOG1439 RAB proteins geranylgeranyltransferase component A (RAB escort protein) Cluster-8309.40286 BF_2 933.97 76.63 797 270004092 EFA00540.1 592 1.2e-58 hypothetical protein TcasGA2_TC003405 [Tribolium castaneum] 827544782 XM_012689556.1 56 2.59205e-18 PREDICTED: Bombyx mori inorganic phosphate co-transporter (LOC100500932), transcript variant X2, mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 440 2.0e-42 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40287 BF_2 598.09 3.97 6582 642914389 XP_008201657.1 2571 3.2e-287 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K08836 SLK STE20-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08836 O54988 1025 2.5e-109 STE20-like serine/threonine-protein kinase OS=Mus musculus GN=Slk PE=1 SV=2 PF07714//PF00069//PF12474 Protein tyrosine kinase//Protein kinase domain//Polo kinase kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.40288 BF_2 56.79 3.57 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40289 BF_2 13.00 1.60 627 91094995 XP_969089.1 192 2.2e-12 PREDICTED: 60S ribosomal protein L35a [Tribolium castaneum]>gi|642939753|ref|XP_008195720.1| PREDICTED: 60S ribosomal protein L35a [Tribolium castaneum]>gi|270015389|gb|EFA11837.1| hypothetical protein TcasGA2_TC002098 [Tribolium castaneum] -- -- -- -- -- K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P49180 155 1.8e-09 60S ribosomal protein L35a OS=Caenorhabditis elegans GN=rpl-33 PE=1 SV=3 PF01782//PF01247 RimM N-terminal domain//Ribosomal protein L35Ae GO:0006364//GO:0042254//GO:0006412 rRNA processing//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0887 60S ribosomal protein L35A/L37 Cluster-8309.40290 BF_2 1982.33 21.83 4086 91078730 XP_966316.1 1601 6.0e-175 PREDICTED: putative inorganic phosphate cotransporter isoform X1 [Tribolium castaneum] 642915952 XM_961223.3 285 6.88498e-145 PREDICTED: Tribolium castaneum putative inorganic phosphate cotransporter (LOC655821), transcript variant X1, mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 1253 5.6e-136 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00845//PF07690//PF00083//PF01907 Geminivirus BL1 movement protein//Major Facilitator Superfamily//Sugar (and other) transporter//Ribosomal protein L37e GO:0055085//GO:0006412//GO:0042254//GO:0046740 transmembrane transport//translation//ribosome biogenesis//transport of virus in host, cell to cell GO:0003677//GO:0022857//GO:0003735 DNA binding//transmembrane transporter activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622//GO:0033644 integral component of membrane//ribosome//intracellular//host cell membrane -- -- Cluster-8309.40291 BF_2 21.77 0.60 1795 478252836 ENN73225.1 1060 1.4e-112 hypothetical protein YQE_10122, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14102 Capsule biosynthesis CapC GO:0045227 capsule polysaccharide biosynthetic process -- -- GO:0016020 membrane -- -- Cluster-8309.40292 BF_2 4.26 0.33 824 546678473 ERL89081.1 771 2.1e-79 hypothetical protein D910_06458 [Dendroctonus ponderosae] -- -- -- -- -- K16055 TPS trehalose 6-phosphate synthase/phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16055 P40387 320 1.7e-28 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=tps1 PE=1 SV=2 PF00982 Glycosyltransferase family 20 GO:0005992 trehalose biosynthetic process GO:0003824 catalytic activity -- -- KOG1050 Trehalose-6-phosphate synthase component TPS1 and related subunits Cluster-8309.40293 BF_2 19.34 0.38 2413 642928523 XP_972628.2 374 6.7e-33 PREDICTED: uncharacterized protein LOC661375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 266 9.2e-22 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF02949//PF08367//PF00089 7tm Odorant receptor//Peptidase M16C associated//Trypsin GO:0006508//GO:0007608//GO:0007187 proteolysis//sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004984//GO:0005549//GO:0004252 olfactory receptor activity//odorant binding//serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.40295 BF_2 2756.35 133.17 1153 478250393 ENN70888.1 1026 8.0e-109 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 Q71SP7 829 2.3e-87 Fatty acid synthase OS=Bos taurus GN=FASN PE=2 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.40296 BF_2 4083.65 37.67 4822 546672885 ERL84608.1 3562 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1055 6.0e-113 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00108//PF08545//PF00107 Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Zinc-binding dehydrogenase GO:0008152//GO:0006633//GO:0042967//GO:0055114 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process//oxidation-reduction process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.40297 BF_2 898.39 7.87 5063 642928449 XP_008193790.1 3616 0.0e+00 PREDICTED: transcriptional-regulating factor 1 isoform X2 [Tribolium castaneum] 642928448 XM_008195568.1 429 0 PREDICTED: Tribolium castaneum transcriptional-regulating factor 1 (LOC103313127), transcript variant X2, mRNA -- -- -- -- Q08DG8 213 2.7e-15 Zinc finger protein 135 OS=Bos taurus GN=ZNF135 PE=2 SV=1 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40300 BF_2 110.96 2.28 2323 478260571 ENN80274.1 605 1.1e-59 hypothetical protein YQE_03268, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06872 EspG protein GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.40301 BF_2 1192.80 9.00 5833 642911463 XP_008199434.1 996 1.2e-104 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF15220//PF03323 MAP7 (E-MAP-115) family//Hypoxia-inducible lipid droplet-associated//Bacillus/Clostridium GerA spore germination protein GO:0010884//GO:0000226//GO:0001819//GO:0008284//GO:0009847 positive regulation of lipid storage//microtubule cytoskeleton organization//positive regulation of cytokine production//positive regulation of cell proliferation//spore germination -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.40303 BF_2 463.01 12.35 1855 642934971 XP_008196003.1 1022 3.7e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 9.63646e-66 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40304 BF_2 229.13 4.64 2355 642926608 XP_969412.2 812 1.1e-83 PREDICTED: histone-lysine N-methyltransferase pr-set7 [Tribolium castaneum] -- -- -- -- -- K11428 SETD8 histone-lysine N-methyltransferase SETD8 http://www.genome.jp/dbget-bin/www_bget?ko:K11428 Q9VFK6 626 1.6e-63 Histone-lysine N-methyltransferase pr-set7 OS=Drosophila melanogaster GN=pr-set7 PE=1 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1085 Predicted methyltransferase (contains a SET domain) Cluster-8309.40305 BF_2 267.73 3.55 3441 91085683 XP_972028.1 2028 1.5e-224 PREDICTED: nucleolar complex protein 3 homolog [Tribolium castaneum] -- -- -- -- -- K14834 NOC3 nucleolar complex protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14834 Q9VI82 1119 1.6e-120 Nucleolar complex protein 3 homolog OS=Drosophila melanogaster GN=CG1234 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2153 Protein involved in the nuclear export of pre-ribosomes Cluster-8309.40307 BF_2 1430.70 11.01 5723 642931601 XP_008196651.1 4639 0.0e+00 PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum]>gi|642931603|ref|XP_008196652.1| PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum] 723941700 KF986386.1 853 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3318 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF04810//PF02171//PF02170 Sec23/Sec24 zinc finger//Piwi domain//PAZ domain GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003676//GO:0008270 protein binding//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.40309 BF_2 8677.32 36.88 10129 478254521 ENN74767.1 2343 1.4e-260 hypothetical protein YQE_08655, partial [Dendroctonus ponderosae] 332374221 BT127290.1 561 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA -- -- -- -- O16011 733 2.7e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF01607//PF00057//PF00642//PF03176//PF01522 Chitin binding Peritrophin-A domain//Low-density lipoprotein receptor domain class A//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//MMPL family//Polysaccharide deacetylase GO:0006030//GO:0005975//GO:0006807 chitin metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process GO:0005515//GO:0046872//GO:0008061//GO:0016810 protein binding//metal ion binding//chitin binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds GO:0016020//GO:0005576 membrane//extracellular region KOG2494 C3H1-type Zn-finger protein Cluster-8309.40311 BF_2 524.28 10.01 2479 91088135 XP_970927.1 2676 8.1e-300 PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum]>gi|642931216|ref|XP_008196487.1| PREDICTED: nuclear protein localization protein 4 homolog [Tribolium castaneum] -- -- -- -- -- K14015 NPLOC4, NPL4 nuclear protein localization protein 4 homolog http://www.genome.jp/dbget-bin/www_bget?ko:K14015 Q9VBP9 1976 4.9e-220 Nuclear protein localization protein 4 homolog OS=Drosophila melanogaster GN=Npl4 PE=1 SV=3 PF00641//PF02565 Zn-finger in Ran binding protein and others//Recombination protein O C terminal GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0008270 zinc ion binding -- -- KOG2834 Nuclear pore complex, rNpl4 component (sc Npl4) Cluster-8309.40312 BF_2 476.92 4.57 4653 642916561 XP_008191701.1 1795 2.2e-197 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U0L2 302 1.2e-25 Ankyrin repeat domain-containing protein 33B OS=Mus musculus GN=Ankrd33b PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40313 BF_2 311.02 2.12 6417 642916561 XP_008191701.1 1854 4.3e-204 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U0L2 302 1.6e-25 Ankyrin repeat domain-containing protein 33B OS=Mus musculus GN=Ankrd33b PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40315 BF_2 39.47 0.72 2586 642928001 XP_008195479.1 4205 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] 642928000 XM_008197257.1 930 0 PREDICTED: Tribolium castaneum neurexin-1 (LOC663759), mRNA K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 A1XQX0 1725 6.5e-191 Neurexin-1a OS=Danio rerio GN=nrxn1a PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.40316 BF_2 47.20 0.53 4016 91078836 XP_971451.1 1905 3.3e-210 PREDICTED: cytosolic non-specific dipeptidase [Tribolium castaneum]>gi|270004128|gb|EFA00576.1| hypothetical protein TcasGA2_TC003446 [Tribolium castaneum] 808126062 XM_012310694.1 133 2.12161e-60 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K08660 CNDP2 cytosolic nonspecific dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08660 Q3ZC84 1568 1.6e-172 Cytosolic non-specific dipeptidase OS=Bos taurus GN=CNDP2 PE=2 SV=1 PF01120//PF01546 Alpha-L-fucosidase//Peptidase family M20/M25/M40 GO:0008152//GO:0006508//GO:0005975 metabolic process//proteolysis//carbohydrate metabolic process GO:0004560//GO:0016787//GO:0034701//GO:0008237//GO:0016805 alpha-L-fucosidase activity//hydrolase activity//tripeptidase activity//metallopeptidase activity//dipeptidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.40317 BF_2 263.23 2.37 4933 642925814 XP_970128.3 565 9.8e-55 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 400 5.5e-37 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF02737//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0006574//GO:0006550//GO:0008152//GO:0006633//GO:0018874//GO:0006568//GO:0006631//GO:0006552//GO:0006554//GO:0055114 valine catabolic process//isoleucine catabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//tryptophan metabolic process//fatty acid metabolic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process GO:0003824//GO:0050662//GO:0016491//GO:0003857 catalytic activity//coenzyme binding//oxidoreductase activity//3-hydroxyacyl-CoA dehydrogenase activity -- -- -- -- Cluster-8309.40318 BF_2 967.62 56.94 998 642920912 XP_008192612.1 755 1.8e-77 PREDICTED: outer dense fiber protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EB30 271 1.0e-22 Outer dense fiber protein 3 OS=Xenopus tropicalis GN=odf3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40320 BF_2 1786.61 22.01 3683 642923778 XP_008193880.1 633 9.5e-63 PREDICTED: zinc finger protein 395 isoform X1 [Tribolium castaneum] 170064362 XM_001867459.1 65 1.22945e-22 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- P04323 300 1.6e-25 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00536//PF08541//PF01416 SAM domain (Sterile alpha motif)//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//tRNA pseudouridine synthase GO:0001522//GO:0009451//GO:0008610 pseudouridine synthesis//RNA modification//lipid biosynthetic process GO:0016747//GO:0005515//GO:0009982//GO:0003723 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//pseudouridine synthase activity//RNA binding -- -- -- -- Cluster-8309.40323 BF_2 945.30 23.33 1982 91076308 XP_969307.1 2397 1.5e-267 PREDICTED: furin-like protease 2 [Tribolium castaneum] 817211511 XM_012426473.1 452 0 PREDICTED: Orussus abietinus furin-like protease 2 (LOC105700544), mRNA K08672 PCSK6 proprotein convertase subtilisin/kexin type 6 http://www.genome.jp/dbget-bin/www_bget?ko:K08672 P30432 2093 1.1e-233 Furin-like protease 2 OS=Drosophila melanogaster GN=Fur2 PE=2 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG3525 Subtilisin-like proprotein convertase Cluster-8309.40325 BF_2 216.61 4.03 2538 189234632 XP_001815875.1 1328 1.7e-143 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.4124e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40326 BF_2 1.00 8.36 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40328 BF_2 2.51 0.55 479 241238985 XP_002401441.1 205 5.3e-14 52 kD repressor of inhibitor of protein kinase, putative [Ixodes scapularis]>gi|215496163|gb|EEC05804.1| 52 kD repressor of inhibitor of protein kinase, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- O43422 189 1.5e-13 52 kDa repressor of the inhibitor of the protein kinase OS=Homo sapiens GN=PRKRIR PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.40329 BF_2 626.08 5.36 5174 831511189 XP_012714153.1 456 4.5e-42 PREDICTED: zinc finger protein 345-like [Fundulus heteroclitus] -- -- -- -- -- -- -- -- -- Q9NYT6 434 6.5e-41 Zinc finger protein 226 OS=Homo sapiens GN=ZNF226 PE=2 SV=2 PF16622//PF05485//PF07776//PF02892//PF13912//PF13465//PF00096 zinc-finger C2H2-type//THAP domain//Zinc-finger associated domain (zf-AD)//BED zinc finger//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677//GO:0003676//GO:0008270 metal ion binding//DNA binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.40331 BF_2 231.32 1.72 5920 189237914 XP_969710.2 1573 1.5e-171 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.55524e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.0e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13499//PF13833//PF10591//PF13405//PF02022//PF08332//PF00036//PF13202 EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Integrase Zinc binding domain//Calcium/calmodulin dependent protein kinase II association domain//EF hand//EF hand GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0004683//GO:0005516//GO:0008270//GO:0005509 calmodulin-dependent protein kinase activity//calmodulin binding//zinc ion binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40332 BF_2 18.62 0.54 1728 189237914 XP_969710.2 1196 2.3e-128 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q06190 154 6.4e-09 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha OS=Homo sapiens GN=PPP2R3A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40333 BF_2 17.58 0.33 2504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40334 BF_2 78.23 0.62 5536 189237914 XP_969710.2 1467 2.8e-159 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.45374e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 9.6e-115 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13202//PF10591//PF13833//PF13405//PF00036//PF13499//PF08332 EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair//Calcium/calmodulin dependent protein kinase II association domain GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0005509//GO:0004683//GO:0005516 calcium ion binding//calmodulin-dependent protein kinase activity//calmodulin binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40335 BF_2 894.41 6.30 6226 189237914 XP_969710.2 1573 1.6e-171 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|642924900|ref|XP_008194089.1| PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X1 [Tribolium castaneum]>gi|270006676|gb|EFA03124.1| hypothetical protein TcasGA2_TC013034 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.63612e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.1e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13202//PF08332//PF00036//PF02022//PF13499//PF10591//PF13833//PF13405 EF hand//Calcium/calmodulin dependent protein kinase II association domain//EF hand//Integrase Zinc binding domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0006468//GO:0009069//GO:0016310//GO:0007165 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//signal transduction GO:0005509//GO:0008270//GO:0004683//GO:0005516 calcium ion binding//zinc ion binding//calmodulin-dependent protein kinase activity//calmodulin binding GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.40336 BF_2 102.68 0.64 7049 546685536 ERL95023.1 2090 2.0e-231 hypothetical protein D910_12293 [Dendroctonus ponderosae] 829939667 XM_012742210.1 103 1.77581e-43 PREDICTED: Microcebus murinus LIM domain kinase 1 (LIMK1), transcript variant X2, mRNA K05743 LIMK1 LIM domain kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05743 Q8IR79 1129 2.3e-121 LIM domain kinase 1 OS=Drosophila melanogaster GN=LIMK1 PE=1 SV=1 PF00069//PF07714//PF16740//PF00170//PF04871//PF10473//PF06160//PF07544//PF08289//PF05929//PF05478//PF00595//PF06009//PF07851//PF05531//PF16331//PF10392//PF00935//PF04728//PF01621//PF00412//PF02601//PF04513 Protein kinase domain//Protein tyrosine kinase//Spindle and kinetochore-associated protein 2//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA//RNA polymerase II transcription mediator complex subunit 9//Influenza Matrix protein (M1) C-terminal domain//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin//PDZ domain (Also known as DHR or GLGF)//Laminin Domain II//TMPIT-like protein//Nucleopolyhedrovirus P10 protein//TolA binding protein trimerisation//Golgi transport complex subunit 5//Ribosomal protein L44//Lipoprotein leucine-zipper//Cell fusion glycoprotein K//LIM domain//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006468//GO:0070206//GO:0006886//GO:0015031//GO:0007059//GO:0006355//GO:0007067//GO:0000090//GO:0031110//GO:0006412//GO:0006308//GO:0019069//GO:0007155//GO:0042254//GO:0006357//GO:0051301//GO:0000921//GO:0006891 protein phosphorylation//protein trimerization//intracellular protein transport//protein transport//chromosome segregation//regulation of transcription, DNA-templated//mitotic nuclear division//mitotic anaphase//regulation of microtubule polymerization or depolymerization//translation//DNA catabolic process//viral capsid assembly//cell adhesion//ribosome biogenesis//regulation of transcription from RNA polymerase II promoter//cell division//septin ring assembly//intra-Golgi vesicle-mediated transport GO:0005198//GO:0008270//GO:0043565//GO:0008565//GO:0008855//GO:0005515//GO:0003723//GO:0042803//GO:0008017//GO:0045502//GO:0008134//GO:0005524//GO:0003700//GO:0003735//GO:0001104//GO:0004672 structural molecule activity//zinc ion binding//sequence-specific DNA binding//protein transporter activity//exodeoxyribonuclease VII activity//protein binding//RNA binding//protein homodimerization activity//microtubule binding//dynein binding//transcription factor binding//ATP binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//RNA polymerase II transcription cofactor activity//protein kinase activity GO:0005940//GO:0016021//GO:0005737//GO:0005876//GO:0005840//GO:0005622//GO:0019031//GO:0019867//GO:0016020//GO:0000940//GO:0017119//GO:0045298//GO:0019028//GO:0009318//GO:0005667//GO:0016592//GO:0030286 septin ring//integral component of membrane//cytoplasm//spindle microtubule//ribosome//intracellular//viral envelope//outer membrane//membrane//condensed chromosome outer kinetochore//Golgi transport complex//tubulin complex//viral capsid//exodeoxyribonuclease VII complex//transcription factor complex//mediator complex//dynein complex -- -- Cluster-8309.40337 BF_2 204.73 4.16 2348 478258505 ENN78580.1 1100 4.3e-117 hypothetical protein YQE_04948, partial [Dendroctonus ponderosae]>gi|546681354|gb|ERL91464.1| hypothetical protein D910_08794 [Dendroctonus ponderosae] -- -- -- -- -- K18729 ANGEL protein angel http://www.genome.jp/dbget-bin/www_bget?ko:K18729 Q5VTE6 611 8.9e-62 Protein angel homolog 2 OS=Homo sapiens GN=ANGEL2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.40340 BF_2 5762.52 55.67 4617 86515394 NP_001034522.1 2216 3.3e-246 pro-phenol oxidase subunit 2 [Tribolium castaneum]>gi|70999576|gb|AAX84205.1| pro-phenol oxidase subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V521 1934 6.8e-215 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 PF00264 Common central domain of tyrosinase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.40341 BF_2 159.00 2.19 3323 91085397 XP_966819.1 1555 1.1e-169 PREDICTED: growth/differentiation factor 8 [Tribolium castaneum]>gi|270009305|gb|EFA05753.1| myoglianin [Tribolium castaneum] 642926716 XM_961726.2 350 0 PREDICTED: Tribolium castaneum myoglianin (LOC655210), mRNA K05497 GDF8_11 growth differentiation factor 8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K05497 Q9Z1W4 622 6.7e-63 Growth/differentiation factor 11 OS=Mus musculus GN=Gdf11 PE=2 SV=1 PF00019//PF00688//PF10538 Transforming growth factor beta like domain//TGF-beta propeptide//Immunoreceptor tyrosine-based activation motif GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity GO:0005576 extracellular region KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.40342 BF_2 239.08 1.17 8831 646710408 KDR15927.1 1192 3.5e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.70322e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 PF11561 Single strand annealing-weakened 1 GO:0000736 double-strand break repair via single-strand annealing, removal of nonhomologous ends GO:0070336 flap-structured DNA binding -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.40343 BF_2 7099.11 56.73 5522 478250929 ENN71414.1 1135 8.8e-121 hypothetical protein YQE_11918, partial [Dendroctonus ponderosae] 642919750 XM_008193828.1 48 5.21528e-13 PREDICTED: Tribolium castaneum nucleosome assembly protein 1-like 1 (LOC103312656), transcript variant X2, mRNA K11279 NAP1L1, NRP nucleosome assembly protein 1-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11279 P55209 825 3.2e-86 Nucleosome assembly protein 1-like 1 OS=Homo sapiens GN=NAP1L1 PE=1 SV=1 PF00852//PF00956//PF04889//PF03606 Glycosyltransferase family 10 (fucosyltransferase) C-term//Nucleosome assembly protein (NAP)//Cwf15/Cwc15 cell cycle control protein//C4-dicarboxylate anaerobic carrier GO:0006486//GO:0000398//GO:0006334 protein glycosylation//mRNA splicing, via spliceosome//nucleosome assembly GO:0008417 fucosyltransferase activity GO:0016020//GO:0005634//GO:0016021//GO:0005681 membrane//nucleus//integral component of membrane//spliceosomal complex KOG1507 Nucleosome assembly protein NAP-1 Cluster-8309.40345 BF_2 19.24 0.70 1430 189238490 XP_001809098.1 788 3.9e-81 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|642926357|ref|XP_008194892.1| PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07973//PF02205 Threonyl and Alanyl tRNA synthetase second additional domain//WH2 motif GO:0043039 tRNA aminoacylation GO:0005524//GO:0016876//GO:0003779 ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//actin binding -- -- -- -- Cluster-8309.40346 BF_2 4296.00 37.57 5071 91090089 XP_975854.1 533 5.2e-51 PREDICTED: protein Tob1 [Tribolium castaneum]>gi|270013495|gb|EFA09943.1| hypothetical protein TcasGA2_TC012096 [Tribolium castaneum] 642934619 XM_970761.2 234 1.91951e-116 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 -- -- -- -- PF01339 CheB methylesterase GO:0000160//GO:0006935 phosphorelay signal transduction system//chemotaxis GO:0008984//GO:0000156 protein-glutamate methylesterase activity//phosphorelay response regulator activity GO:0005737 cytoplasm -- -- Cluster-8309.40347 BF_2 12855.58 64.37 8642 746835597 XP_011068495.1 2501 5.5e-279 PREDICTED: uncharacterized protein LOC105154570 isoform X8 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q62417 536 1.6e-52 Sorbin and SH3 domain-containing protein 1 OS=Mus musculus GN=Sorbs1 PE=1 SV=2 PF12549//PF14604//PF00383//PF00018 Tyrosine hydroxylase N terminal//Variant SH3 domain//Cytidine and deoxycytidylate deaminase zinc-binding region//SH3 domain GO:0055114//GO:0006570 oxidation-reduction process//tyrosine metabolic process GO:0008270//GO:0004511//GO:0005515 zinc ion binding//tyrosine 3-monooxygenase activity//protein binding -- -- KOG4225 Sorbin and SH3 domain-containing protein Cluster-8309.40348 BF_2 101.36 1.02 4453 478254003 ENN74295.1 1276 3.2e-137 hypothetical protein YQE_09267, partial [Dendroctonus ponderosae]>gi|546673725|gb|ERL85281.1| hypothetical protein D910_02702 [Dendroctonus ponderosae] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 P13280 850 3.3e-89 Glycogenin-1 OS=Oryctolagus cuniculus GN=GYG1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.40351 BF_2 6368.57 154.64 2010 332373698 AEE61990.1 2442 8.9e-273 unknown [Dendroctonus ponderosae] 630581065 KF383704.1 194 1.2965e-94 Tectarchus salebrosus isolate TES phosphoglucose isomerase (Pgi) mRNA, Pgi-1 allele, partial cds K01810 GPI, pgi glucose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01810 P52031 2165 4.8e-242 Glucose-6-phosphate isomerase OS=Drosophila yakuba GN=Pgi PE=3 SV=1 PF11593//PF02792//PF00342 Mediator complex subunit 3 fungal//Mago nashi protein//Phosphoglucose isomerase GO:0006096//GO:0005982//GO:0006098//GO:0005985//GO:0006094//GO:0006357 glycolytic process//starch metabolic process//pentose-phosphate shunt//sucrose metabolic process//gluconeogenesis//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0004347 RNA polymerase II transcription cofactor activity//glucose-6-phosphate isomerase activity GO:0005634//GO:0016592 nucleus//mediator complex KOG2446 Glucose-6-phosphate isomerase Cluster-8309.40352 BF_2 11779.63 251.05 2250 189234454 XP_967960.2 2239 3.5e-249 PREDICTED: aldehyde dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270002022|gb|EEZ98469.1| hypothetical protein TcasGA2_TC000960 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11884 1751 5.5e-194 Aldehyde dehydrogenase, mitochondrial OS=Rattus norvegicus GN=Aldh2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016620//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.40355 BF_2 3.00 0.80 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00283 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits GO:0015979 photosynthesis -- -- -- -- -- -- Cluster-8309.40361 BF_2 25.42 0.43 2777 270016295 EFA12741.1 1301 2.5e-140 Rm62 [Tribolium castaneum] 194745413 XM_001955147.1 238 6.24472e-119 Drosophila ananassae GF18634 (Dana\GF18634), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1121 7.6e-121 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0016787//GO:0003677//GO:0003676//GO:0005524 hydrolase activity//DNA binding//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40362 BF_2 414.99 4.50 4148 270015108 EFA11556.1 1793 3.3e-197 plexin B [Tribolium castaneum] 642910642 XM_008201819.1 310 8.85273e-159 PREDICTED: Tribolium castaneum plexin-B (LOC656639), mRNA -- -- -- -- Q9V4A7 1057 3.0e-113 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF00293//PF01403//PF02600 NUDIX domain//Sema domain//Disulfide bond formation protein DsbB GO:0006118 obsolete electron transport GO:0015035//GO:0016787//GO:0005515 protein disulfide oxidoreductase activity//hydrolase activity//protein binding GO:0016020 membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.40364 BF_2 2333.33 10.34 9731 642910643 XP_008200041.1 6865 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: plexin-B [Tribolium castaneum] 571537979 XM_395735.5 266 6.00975e-134 PREDICTED: Apis mellifera plexin B (plexB), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 Q9V4A7 4832 0.0e+00 Plexin-B OS=Drosophila melanogaster GN=plexB PE=1 SV=2 PF01833//PF01756//PF04414//PF01403//PF00441//PF02770//PF01437 IPT/TIG domain//Acyl-CoA oxidase//D-aminoacyl-tRNA deacylase//Sema domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Plexin repeat GO:0006118//GO:0055114//GO:0006637//GO:0006635 obsolete electron transport//oxidation-reduction process//acyl-CoA metabolic process//fatty acid beta-oxidation GO:0003997//GO:0051499//GO:0016627//GO:0003995//GO:0016788//GO:0005515 acyl-CoA oxidase activity//D-aminoacyl-tRNA deacylase activity//oxidoreductase activity, acting on the CH-CH group of donors//acyl-CoA dehydrogenase activity//hydrolase activity, acting on ester bonds//protein binding GO:0016020//GO:0005777 membrane//peroxisome KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.40365 BF_2 3.03 0.60 500 -- -- -- -- -- 642911796 XM_008202524.1 77 3.36307e-30 PREDICTED: Tribolium castaneum protein tyrosine phosphatase type IVA 1 (LOC660914), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40366 BF_2 788.88 5.73 6048 642924598 XP_008194358.1 2026 4.6e-224 PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924600|ref|XP_008194359.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum]>gi|642924602|ref|XP_008194360.1| PREDICTED: rho-associated protein kinase 1 [Tribolium castaneum] 827557233 XM_012694434.1 87 1.19415e-34 PREDICTED: Bombyx mori Rho-associated protein kinase (rock1), transcript variant X1, mRNA K17388 ROCK2 Rho-associated protein kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17388 M3TYT0 1033 2.7e-110 Rho-associated protein kinase 2 OS=Sus scrofa GN=ROCK2 PE=1 SV=1 PF00130//PF08912//PF01420//PF00769//PF04513 Phorbol esters/diacylglycerol binding domain (C1 domain)//Rho Binding//Type I restriction modification DNA specificity domain//Ezrin/radixin/moesin family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0035556//GO:0006304 intracellular signal transduction//DNA modification GO:0005198//GO:0008092//GO:0003677//GO:0017048 structural molecule activity//cytoskeletal protein binding//DNA binding//Rho GTPase binding GO:0019031//GO:0019028//GO:0019898//GO:0005737 viral envelope//viral capsid//extrinsic component of membrane//cytoplasm KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.40368 BF_2 82.00 47.14 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40370 BF_2 1783.00 7.22 10613 91084143 XP_970053.1 5407 0.0e+00 PREDICTED: glutamate synthase 1 [NADH], chloroplastic isoform X2 [Tribolium castaneum]>gi|270006644|gb|EFA03092.1| hypothetical protein TcasGA2_TC013000 [Tribolium castaneum] 642925099 XM_964960.2 890 0 PREDICTED: Tribolium castaneum glutamate synthase 1 [NADH], chloroplastic (LOC658584), transcript variant X3, mRNA K00264 GLT1 glutamate synthase (NADPH/NADH) http://www.genome.jp/dbget-bin/www_bget?ko:K00264 Q9LV03 3249 0.0e+00 Glutamate synthase 1 [NADH], chloroplastic OS=Arabidopsis thaliana GN=GLT1 PE=2 SV=2 PF00070//PF01493//PF01210//PF01266//PF01645//PF04183//PF01593//PF12831//PF00743//PF04898//PF01070//PF00869//PF01134//PF05834//PF13241//PF00833//PF07992//PF00287//PF01494 Pyridine nucleotide-disulphide oxidoreductase//GXGXG motif//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//FAD dependent oxidoreductase//Conserved region in glutamate synthase//IucA / IucC family//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Flavin-binding monooxygenase-like//Glutamate synthase central domain//FMN-dependent dehydrogenase//Flavivirus glycoprotein, central and dimerisation domains//Glucose inhibited division protein A//Lycopene cyclase protein//Putative NAD(P)-binding//Ribosomal S17//Pyridine nucleotide-disulphide oxidoreductase//Sodium / potassium ATPase beta chain//FAD binding domain GO:0019354//GO:0008152//GO:0046168//GO:0016117//GO:0019290//GO:0006814//GO:0006118//GO:0055114//GO:0042254//GO:0006779//GO:0006813//GO:0006412//GO:0006807//GO:0006537//GO:0006826//GO:0008033 siroheme biosynthetic process//metabolic process//glycerol-3-phosphate catabolic process//carotenoid biosynthetic process//siderophore biosynthetic process//sodium ion transport//obsolete electron transport//oxidation-reduction process//ribosome biogenesis//porphyrin-containing compound biosynthetic process//potassium ion transport//translation//nitrogen compound metabolic process//glutamate biosynthetic process//iron ion transport//tRNA processing GO:0043115//GO:0046983//GO:0016491//GO:0015930//GO:0010181//GO:0016616//GO:0003735//GO:0005506//GO:0016705//GO:0050661//GO:0004499//GO:0051287//GO:0016040//GO:0050660//GO:0071949//GO:0015343//GO:0051536//GO:0016638 precorrin-2 dehydrogenase activity//protein dimerization activity//oxidoreductase activity//glutamate synthase activity//FMN binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//NADP binding//N,N-dimethylaniline monooxygenase activity//NAD binding//glutamate synthase (NADH) activity//flavin adenine dinucleotide binding//FAD binding//siderophore transmembrane transporter activity//iron-sulfur cluster binding//oxidoreductase activity, acting on the CH-NH2 group of donors GO:0005890//GO:0005840//GO:0005622 sodium:potassium-exchanging ATPase complex//ribosome//intracellular KOG0399 Glutamate synthase Cluster-8309.40372 BF_2 172.00 12.90 845 642925601 XP_001812139.2 188 8.7e-12 PREDICTED: uncharacterized protein LOC660114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- -- -- Cluster-8309.40374 BF_2 1477.24 9.97 6486 642914186 XP_008201580.1 1615 2.3e-176 PREDICTED: uncharacterized protein LOC661670 isoform X1 [Tribolium castaneum]>gi|270002176|gb|EEZ98623.1| hypothetical protein TcasGA2_TC001146 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40375 BF_2 442.00 10.60 2032 478256698 ENN76880.1 1470 4.6e-160 hypothetical protein YQE_06721, partial [Dendroctonus ponderosae] 642911481 XM_968458.3 125 2.98175e-56 PREDICTED: Tribolium castaneum protein BCL9 homolog (LOC662357), mRNA -- -- -- -- Q961D9 203 1.6e-14 Protein BCL9 homolog OS=Drosophila melanogaster GN=lgs PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40376 BF_2 182.01 2.31 3581 91076812 XP_974369.1 922 2.8e-96 PREDICTED: Krueppel-like factor 13 [Tribolium castaneum]>gi|270001931|gb|EEZ98378.1| hypothetical protein TcasGA2_TC000837 [Tribolium castaneum] 667677333 AE014297.3 36 1.57907e-06 Drosophila melanogaster chromosome 3R K09208 KLF9S, BTEB krueppel-like factor 9/13/14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K09208 Q9Y2Y9 418 3.2e-39 Krueppel-like factor 13 OS=Homo sapiens GN=KLF13 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40377 BF_2 593.69 6.27 4247 642938734 XP_967034.2 3818 0.0e+00 PREDICTED: integrator complex subunit 3 homolog [Tribolium castaneum] -- -- -- -- -- K13140 INTS3 integrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13140 Q7PRB8 2253 6.4e-252 Integrator complex subunit 3 homolog OS=Anopheles gambiae GN=AGAP002539 PE=3 SV=5 -- -- -- -- -- -- -- -- KOG4262 Uncharacterized conserved protein Cluster-8309.40378 BF_2 30.00 0.49 2845 642930416 XP_008196392.1 623 1.1e-61 PREDICTED: stAR-related lipid transfer protein 3 [Tribolium castaneum]>gi|270011106|gb|EFA07554.1| Start1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DFS4 333 1.9e-29 StAR-related lipid transfer protein 3 OS=Danio rerio GN=stard3 PE=2 SV=2 PF01852 START domain -- -- GO:0008289 lipid binding -- -- KOG3845 MLN, STAR and related lipid-binding proteins Cluster-8309.40379 BF_2 309.00 5.73 2542 478250613 ENN71105.1 2284 2.4e-254 hypothetical protein YQE_12038, partial [Dendroctonus ponderosae]>gi|546673107|gb|ERL84776.1| hypothetical protein D910_02201 [Dendroctonus ponderosae] -- -- -- -- -- K06058 DTX deltex http://www.genome.jp/dbget-bin/www_bget?ko:K06058 Q8R3P2 649 3.8e-66 Probable E3 ubiquitin-protein ligase DTX2 OS=Mus musculus GN=Dtx2 PE=1 SV=2 PF00628//PF14634//PF17123//PF12678//PF00097//PF17122//PF13639//PF12861 PHD-finger//zinc-RING finger domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.40382 BF_2 590.32 4.00 6462 642915533 XP_008190655.1 1572 2.2e-171 PREDICTED: tyrosine-protein phosphatase non-receptor type 61F isoform X1 [Tribolium castaneum] -- -- -- -- -- K18026 PTPN2, PTPT tyrosine-protein phosphatase non-receptor type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18026 Q9W0G1 859 4.3e-90 Tyrosine-protein phosphatase non-receptor type 61F OS=Drosophila melanogaster GN=Ptp61F PE=1 SV=1 PF03119//PF00102//PF00782//PF01396//PF08043//PF03248 NAD-dependent DNA ligase C4 zinc finger domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//Topoisomerase DNA binding C4 zinc finger//Xin repeat//Rer1 family GO:0006260//GO:0006265//GO:0030036//GO:0006281//GO:0006470//GO:0006570 DNA replication//DNA topological change//actin cytoskeleton organization//DNA repair//protein dephosphorylation//tyrosine metabolic process GO:0003677//GO:0003911//GO:0004725//GO:0008138//GO:0003779//GO:0003916 DNA binding//DNA ligase (NAD+) activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//actin binding//DNA topoisomerase activity GO:0005694//GO:0030054//GO:0016021 chromosome//cell junction//integral component of membrane -- -- Cluster-8309.40383 BF_2 457.43 7.74 2761 642921053 XP_008192672.1 2472 4.1e-276 PREDICTED: serine/threonine-protein phosphatase rdgC [Tribolium castaneum] -- -- -- -- -- K13807 PPEF, PPP7C serine/threonine-protein phosphatase with EF-hands http://www.genome.jp/dbget-bin/www_bget?ko:K13807 P40421 1663 1.1e-183 Serine/threonine-protein phosphatase rdgC OS=Drosophila melanogaster GN=rdgC PE=2 SV=1 PF12763//PF00612//PF13499//PF13405//PF10591//PF13833//PF13202//PF00149//PF00036 Cytoskeletal-regulatory complex EF hand//IQ calmodulin-binding motif//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//Calcineurin-like phosphoesterase//EF hand GO:0007165 signal transduction GO:0005509//GO:0016787//GO:0005515 calcium ion binding//hydrolase activity//protein binding GO:0005578 proteinaceous extracellular matrix KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.40384 BF_2 103.96 1.75 2776 328717537 XP_001947862.2 192 9.8e-12 PREDICTED: pancreatic triacylglycerol lipase-like [Acyrthosiphon pisum] -- -- -- -- -- K01059 LPL lipoprotein lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01059 A5PK46 179 1.3e-11 Pancreatic lipase-related protein 2 OS=Bos taurus GN=PNLIPRP2 PE=2 SV=1 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.40387 BF_2 321.94 5.36 2801 642910948 XP_008193477.1 1852 3.2e-204 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 P23687 1214 1.3e-131 Prolyl endopeptidase OS=Sus scrofa GN=PREP PE=1 SV=1 PF00326//PF02897 Prolyl oligopeptidase family//Prolyl oligopeptidase, N-terminal beta-propeller domain GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0070008 serine-type peptidase activity//serine-type endopeptidase activity//serine-type exopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.40389 BF_2 145.48 3.25 2159 189237054 XP_966641.2 758 1.8e-77 PREDICTED: bcl-2-related ovarian killer protein [Tribolium castaneum]>gi|270007277|gb|EFA03725.1| hypothetical protein TcasGA2_TC013830 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I8I2 201 2.8e-14 Bcl-2-related ovarian killer protein OS=Gallus gallus GN=BOK PE=2 SV=1 PF00452//PF14489 Apoptosis regulator proteins, Bcl-2 family//QueF-like protein GO:0008616//GO:0042981 queuosine biosynthetic process//regulation of apoptotic process GO:0033739 preQ1 synthase activity -- -- -- -- Cluster-8309.40390 BF_2 109.75 0.77 6277 91094947 XP_968721.1 2301 6.2e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF06815//PF02295//PF09606 Reverse transcriptase connection domain//Adenosine deaminase z-alpha domain//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006807//GO:0006357//GO:0006278 nitrogen compound metabolic process//regulation of transcription from RNA polymerase II promoter//RNA-dependent DNA replication GO:0003726//GO:0003723//GO:0001104//GO:0003964 double-stranded RNA adenosine deaminase activity//RNA binding//RNA polymerase II transcription cofactor activity//RNA-directed DNA polymerase activity GO:0016592 mediator complex KOG2432 Uncharacterized conserved protein Cluster-8309.40391 BF_2 1995.22 30.88 2990 478251374 ENN71840.1 3372 0.0e+00 hypothetical protein YQE_11459, partial [Dendroctonus ponderosae] 642926047 XM_964823.2 392 0 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 2568 1.3e-288 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00171//PF02911 Aldehyde dehydrogenase family//Formyl transferase, C-terminal domain GO:0008152//GO:0009058//GO:0055114 metabolic process//biosynthetic process//oxidation-reduction process GO:0016742//GO:0016491 hydroxymethyl-, formyl- and related transferase activity//oxidoreductase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.40392 BF_2 2.00 73.08 204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40393 BF_2 36.94 1.02 1801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40394 BF_2 1708.81 41.81 1997 91082535 XP_973659.1 1816 3.4e-200 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007558|gb|EFA04006.1| hypothetical protein TcasGA2_TC014155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 787 2.9e-82 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083//PF07578//PF08573 Major Facilitator Superfamily//Sugar (and other) transporter//Lipid A Biosynthesis N-terminal domain//DNA repair protein endonuclease SAE2/CtIP C-terminus GO:0006308//GO:0000077//GO:0006281//GO:0009245//GO:0055085 DNA catabolic process//DNA damage checkpoint//DNA repair//lipid A biosynthetic process//transmembrane transport GO:0000014//GO:0008915//GO:0022857 single-stranded DNA endodeoxyribonuclease activity//lipid-A-disaccharide synthase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.40395 BF_2 400.79 8.45 2272 373842654 AEY77316.1 404 2.1e-36 extracellular Cu/Zn-superoxide dismutase [Phaedon cochleariae] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P24704 315 1.8e-27 Superoxide dismutase [Cu-Zn] 1 OS=Arabidopsis thaliana GN=CSD1 PE=1 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.40396 BF_2 448.78 5.11 3960 642917882 XP_008191369.1 1010 2.0e-106 PREDICTED: uncharacterized protein LOC103312469 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64322 300 1.7e-25 Neural proliferation differentiation and control protein 1 OS=Mus musculus GN=Npdc1 PE=2 SV=2 PF06809 Neural proliferation differentiation control-1 protein (NPDC1) -- -- -- -- GO:0016021 integral component of membrane KOG3884 Neural proliferation, differentiation and control protein Cluster-8309.40398 BF_2 1113.94 10.44 4749 546685733 ERL95188.1 972 6.0e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 4.0e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF13639//PF14634 Ring finger domain//zinc-RING finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.40399 BF_2 3819.35 67.91 2640 546682278 ERL92239.1 2240 3.1e-249 hypothetical protein D910_09556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 245 2.7e-19 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF00452//PF07926 Apoptosis regulator proteins, Bcl-2 family//TPR/MLP1/MLP2-like protein GO:0042981//GO:0006606 regulation of apoptotic process//protein import into nucleus -- -- -- -- -- -- Cluster-8309.404 BF_2 8.00 0.98 630 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02979//PF05159//PF03286 Nitrile hydratase, alpha chain//Capsule polysaccharide biosynthesis protein//Pox virus Ag35 surface protein GO:0006807//GO:0015774//GO:0000271 nitrogen compound metabolic process//polysaccharide transport//polysaccharide biosynthetic process GO:0046914//GO:0003824 transition metal ion binding//catalytic activity GO:0019031 viral envelope -- -- Cluster-8309.40401 BF_2 431.00 13.51 1622 642920110 XP_008192209.1 602 1.6e-59 PREDICTED: putative oxidoreductase GLYR1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q161 532 8.9e-53 Putative oxidoreductase GLYR1 homolog OS=Anopheles gambiae GN=AGAP009949 PE=3 SV=5 PF02737//PF05051//PF14833//PF13241//PF03435//PF01210//PF02558//PF02826//PF03446 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Cytochrome C oxidase copper chaperone (COX17)//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Putative NAD(P)-binding//Saccharopine dehydrogenase NADP binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006552//GO:0006631//GO:0046168//GO:0019354//GO:0006633//GO:0018874//GO:0006098//GO:0006779//GO:0006554//GO:0055114//GO:0019521//GO:0006568//GO:0006825//GO:0015940//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//glycerol-3-phosphate catabolic process//siroheme biosynthetic process//fatty acid biosynthetic process//benzoate metabolic process//pentose-phosphate shunt//porphyrin-containing compound biosynthetic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process//copper ion transport//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process GO:0008677//GO:0016491//GO:0051287//GO:0005507//GO:0043115//GO:0016531//GO:0004616//GO:0003857//GO:0016616 2-dehydropantoate 2-reductase activity//oxidoreductase activity//NAD binding//copper ion binding//precorrin-2 dehydrogenase activity//copper chaperone activity//phosphogluconate dehydrogenase (decarboxylating) activity//3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005758 mitochondrial intermembrane space KOG0409 Predicted dehydrogenase Cluster-8309.40402 BF_2 2.70 0.41 565 270004866 EFA01314.1 177 1.1e-10 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0A8J8 142 5.2e-08 Angiopoietin-2 OS=Canis familiaris GN=ANGPT2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40404 BF_2 50.08 4.42 761 270004866 EFA01314.1 634 1.5e-63 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 452 7.9e-44 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40406 BF_2 483.69 12.89 1857 270010830 EFA07278.1 1126 3.3e-120 hypothetical protein TcasGA2_TC014512 [Tribolium castaneum] 299884466 FP926002.1 78 3.64585e-30 Acyrthosiphon pisum mRNA, clone: ACI0AAF31YL22, full-insert cDNA sequence based on ESTs (5'-EST:ACI0AAF31YL22AAM1, 3'-EST ACI2AAF5YG16BBM1) K02678 ETS, pnt c-ets proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K02678 P51023 606 2.7e-61 ETS-like protein pointed, isoform P2/D OS=Drosophila melanogaster GN=pnt PE=2 SV=2 PF00447//PF00178 HSF-type DNA-binding//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40407 BF_2 1085.66 4.69 9968 642912029 XP_008199066.1 3032 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 468 1.4e-44 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF00873//PF04319//PF02460//PF03176 AcrB/AcrD/AcrF family//NifZ domain//Patched family//MMPL family GO:0006810//GO:0009399//GO:0007165 transport//nitrogen fixation//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.4041 BF_2 5.00 1.21 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40413 BF_2 178.34 1.76 4533 646717218 KDR20164.1 788 1.2e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.44275e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.8e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.40414 BF_2 104.84 0.77 6013 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40416 BF_2 118.68 1.10 4786 478251184 ENN71660.1 1199 2.9e-128 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K02330 POLB DNA polymerase beta http://www.genome.jp/dbget-bin/www_bget?ko:K02330 O57383 937 2.9e-99 DNA polymerase beta OS=Xenopus laevis GN=polb PE=1 SV=3 PF01909//PF00633//PF01367//PF10391//PF00328 Nucleotidyltransferase domain//Helix-hairpin-helix motif//5'-3' exonuclease, C-terminal SAM fold//Fingers domain of DNA polymerase lambda//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0034061//GO:0003677//GO:0003824//GO:0016779//GO:0003993 DNA polymerase activity//DNA binding//catalytic activity//nucleotidyltransferase activity//acid phosphatase activity GO:0005634 nucleus -- -- Cluster-8309.40418 BF_2 243.29 1.42 7472 642929587 XP_975389.2 4335 0.0e+00 PREDICTED: uncharacterized protein LOC664289 isoform X3 [Tribolium castaneum] 642929586 XM_970296.2 70 4.16326e-25 PREDICTED: Tribolium castaneum uncharacterized LOC664289 (LOC664289), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40420 BF_2 223.86 1.07 9041 642923740 XP_008193866.1 1948 7.7e-215 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X8 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 O35547 1209 1.6e-130 Long-chain-fatty-acid--CoA ligase 4 OS=Rattus norvegicus GN=Acsl4 PE=1 SV=1 PF06624//PF00908//PF15138//PF09259//PF00501 Ribosome associated membrane protein RAMP4//dTDP-4-dehydrorhamnose 3,5-epimerase//Syncollin//Fungal immunomodulatory protein Fve//AMP-binding enzyme GO:0002682//GO:0006887//GO:0009117//GO:0019872//GO:0008152//GO:0030639 regulation of immune system process//exocytosis//nucleotide metabolic process//streptomycin biosynthetic process//metabolic process//polyketide biosynthetic process GO:0008830//GO:0030246//GO:0003824 dTDP-4-dehydrorhamnose 3,5-epimerase activity//carbohydrate binding//catalytic activity GO:0005783//GO:0030667 endoplasmic reticulum//secretory granule membrane KOG1180 Acyl-CoA synthetase Cluster-8309.40421 BF_2 238.42 7.85 1557 642929019 XP_008195657.1 726 6.6e-74 PREDICTED: uncharacterized protein LOC662417 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00031 Cystatin domain -- -- GO:0004869 cysteine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.40422 BF_2 7.95 0.59 854 190702371 ACE75264.1 758 7.1e-78 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40423 BF_2 28.00 0.65 2095 270012045 EFA08493.1 1034 1.7e-109 hypothetical protein TcasGA2_TC006145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.40424 BF_2 149.54 1.82 3724 642928866 XP_008195596.1 3145 0.0e+00 PREDICTED: protein EFR3 homolog cmp44E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IGJ0 2001 9.3e-223 Protein EFR3 homolog cmp44E OS=Drosophila melanogaster GN=stmA PE=2 SV=3 PF07244//PF05000 Surface antigen variable number repeat//RNA polymerase Rpb1, domain 4 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0019867 nucleolus//outer membrane KOG1877 Putative transmembrane protein cmp44E Cluster-8309.40425 BF_2 76.23 0.57 5840 642925144 XP_008194444.1 1180 5.6e-126 PREDICTED: WSCD family member AGAP003962 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16WU7 876 4.1e-92 WSCD family member AAEL009094 OS=Aedes aegypti GN=AAEL009094 PE=3 SV=1 PF02485//PF01356//PF00569//PF00685 Core-2/I-Branching enzyme//Alpha amylase inhibitor//Zinc finger, ZZ type//Sulfotransferase domain -- -- GO:0015066//GO:0008146//GO:0008270//GO:0008375 alpha-amylase inhibitor activity//sulfotransferase activity//zinc ion binding//acetylglucosaminyltransferase activity GO:0016020 membrane -- -- Cluster-8309.40426 BF_2 241.00 9.10 1395 478257591 ENN77745.1 915 7.2e-96 hypothetical protein YQE_05815, partial [Dendroctonus ponderosae]>gi|546677145|gb|ERL88042.1| hypothetical protein D910_05431 [Dendroctonus ponderosae] -- -- -- -- -- K18666 ASCC1 activating signal cointegrator complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18666 Q9D8Z1 480 8.2e-47 Activating signal cointegrator 1 complex subunit 1 OS=Mus musculus GN=Ascc1 PE=2 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2814 Transcription coactivator complex, P50 component (LigT RNA ligase/phosphodiesterase family) Cluster-8309.40428 BF_2 31.77 0.49 2987 640802703 XP_008057688.1 799 4.4e-82 PREDICTED: zinc finger protein 658B-like [Tarsius syrichta] -- -- -- -- -- -- -- -- -- Q14590 778 4.9e-81 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF13465//PF00096//PF07776//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.40429 BF_2 27.14 0.38 3271 282165792 NP_001164135.1 183 1.3e-10 drongo protein isoform 2 [Tribolium castaneum]>gi|270008252|gb|EFA04700.1| drongo [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40430 BF_2 2296.45 89.46 1361 332372732 AEE61508.1 1136 1.7e-121 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 758 4.6e-79 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00191//PF08294//PF00802 Annexin//TIM21//Pneumovirus attachment glycoprotein G GO:0030150 protein import into mitochondrial matrix GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding GO:0005744//GO:0055036 mitochondrial inner membrane presequence translocase complex//virion membrane KOG0819 Annexin Cluster-8309.40431 BF_2 226.29 7.89 1487 546681897 ERL91906.1 667 4.4e-67 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 321 2.4e-28 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40432 BF_2 82.07 0.35 10089 642914147 XP_008201565.1 9361 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1238 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.2e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.40433 BF_2 546.42 15.50 1762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.40434 BF_2 316.91 7.37 2085 642923280 XP_008193688.1 149 7.2e-07 PREDICTED: long-chain fatty acid transport protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00487//PF06703//PF03419 Fatty acid desaturase//Microsomal signal peptidase 25 kDa subunit (SPC25)//Sporulation factor SpoIIGA GO:0030436//GO:0006508//GO:0006465//GO:0006629 asexual sporulation//proteolysis//signal peptide processing//lipid metabolic process GO:0008233//GO:0004190 peptidase activity//aspartic-type endopeptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.40435 BF_2 585.10 2.23 11262 642918088 XP_008193953.1 2255 2.4e-250 PREDICTED: uncharacterized protein LOC103313170 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17480 AATK, LMTK1 lemur tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17480 Q6ZMQ8 601 6.1e-60 Serine/threonine-protein kinase LMTK1 OS=Homo sapiens GN=AATK PE=1 SV=2 PF14991//PF07402//PF07714//PF00069 Protein melan-A//Human herpesvirus U26 protein//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0042470//GO:0016021 melanosome//integral component of membrane -- -- Cluster-8309.40436 BF_2 88.94 2.07 2081 478249899 ENN70406.1 717 9.8e-73 hypothetical protein YQE_12912, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VCH8 360 1.0e-32 Transmembrane protein 65 OS=Bos taurus GN=TMEM65 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4619 Uncharacterized conserved protein Cluster-8309.40437 BF_2 134.39 1.99 3112 642913255 XP_008201459.1 819 2.2e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 7.36372e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.8e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367//PF01024 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//Colicin pore forming domain GO:0050829//GO:0019835 defense response to Gram-negative bacterium//cytolysis GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding GO:0016021 integral component of membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40438 BF_2 285.20 4.43 2983 642913258 XP_008201460.1 819 2.1e-84 PREDICTED: RNA-binding protein squid isoform X3 [Tribolium castaneum] 506968668 KC740854.1 175 7.0549e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.5e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF01024//PF16367//PF00076 Colicin pore forming domain//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0003676 nucleic acid binding GO:0016021 integral component of membrane KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.40439 BF_2 3293.39 35.55 4162 332374310 AEE62296.1 1023 6.4e-108 unknown [Dendroctonus ponderosae]>gi|546677344|gb|ERL88201.1| hypothetical protein D910_05589 [Dendroctonus ponderosae] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 O80944 474 1.2e-45 Aldo-keto reductase family 4 member C8 OS=Arabidopsis thaliana GN=AKR4C8 PE=1 SV=2 PF01353 Green fluorescent protein GO:0008218 bioluminescence -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.40440 BF_2 733.62 4.29 7435 332376114 AEE63197.1 1491 6.2e-162 unknown [Dendroctonus ponderosae] 332376113 BT128237.1 195 1.34943e-94 Dendroctonus ponderosae clone DPO084_I14 unknown mRNA -- -- -- -- A1ZA47 900 8.7e-95 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF00412//PF13180//PF05493//PF07994 PDZ domain (Also known as DHR or GLGF)//LIM domain//PDZ domain//ATP synthase subunit H//Myo-inositol-1-phosphate synthase GO:0008654//GO:0015992//GO:0019872//GO:0015991//GO:0006021 phospholipid biosynthetic process//proton transport//streptomycin biosynthetic process//ATP hydrolysis coupled proton transport//inositol biosynthetic process GO:0015078//GO:0008270//GO:0004512//GO:0005515 hydrogen ion transmembrane transporter activity//zinc ion binding//inositol-3-phosphate synthase activity//protein binding GO:0033179 proton-transporting V-type ATPase, V0 domain KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40441 BF_2 54.50 0.77 3239 332372624 AEE61454.1 1753 1.1e-192 unknown [Dendroctonus ponderosae] 645007963 XM_008205563.1 265 7.14403e-134 PREDICTED: Nasonia vitripennis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (LOC100118240), transcript variant X4, mRNA K11648 SMARCB1, SNF5, INI1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11648 Q6DFM1 1331 4.0e-145 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xenopus tropicalis GN=smarcb1 PE=2 SV=1 PF04855//PF08039 SNF5 / SMARCB1 / INI1//Mitochondrial proteolipid GO:0006338 chromatin remodeling -- -- GO:0005739//GO:0000228 mitochondrion//nuclear chromosome KOG1649 SWI-SNF chromatin remodeling complex, Snf5 subunit Cluster-8309.40442 BF_2 10.67 0.45 1288 546675964 ERL87059.1 1145 1.4e-122 hypothetical protein D910_04460, partial [Dendroctonus ponderosae] 641676797 XM_008189320.1 35 2.00803e-06 PREDICTED: Acyrthosiphon pisum PDZ and LIM domain protein Zasp (LOC100162539), transcript variant X5, mRNA -- -- -- -- A1ZA47 655 3.8e-67 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40444 BF_2 294.23 6.31 2238 189234482 XP_970034.2 1070 1.2e-113 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270001732|gb|EEZ98179.1| hypothetical protein TcasGA2_TC000608 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q8UWA5 340 2.2e-30 Carbonic anhydrase 2 OS=Tribolodon hakonensis GN=ca2 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40445 BF_2 996.77 4.37 9827 642925384 XP_008194526.1 13580 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [Tribolium castaneum] 815805023 XM_012367811.1 84 9.04437e-33 PREDICTED: Linepithema humile transcription-associated protein 1 (LOC105672707), mRNA K08874 TRRAP transformation/transcription domain-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08874 Q9Y4A5 8483 0.0e+00 Transformation/transcription domain-associated protein OS=Homo sapiens GN=TRRAP PE=1 SV=3 PF02259 FAT domain -- -- GO:0005515 protein binding -- -- KOG0889 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily Cluster-8309.40446 BF_2 337.31 8.55 1937 642936134 XP_008198313.1 2536 1.1e-283 PREDICTED: ABC transporter G family member 20 isoform X2 [Tribolium castaneum] 642936133 XM_008200091.1 514 0 PREDICTED: Tribolium castaneum ABC transporter G family member 20 (LOC663804), transcript variant X2, mRNA -- -- -- -- Q55EH8 680 7.3e-70 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF01061//PF13304//PF00005//PF03193 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 -- -- GO:0016887//GO:0005524//GO:0005525//GO:0003924 ATPase activity//ATP binding//GTP binding//GTPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.40447 BF_2 1496.71 54.74 1431 546681897 ERL91906.1 923 8.7e-97 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 459 2.3e-44 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40448 BF_2 2.00 0.45 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40449 BF_2 1666.48 7.22 9948 642914147 XP_008201565.1 9307 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1202 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.1e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.40451 BF_2 91.49 1.42 2984 91087251 XP_975522.1 358 6.0e-31 PREDICTED: uncharacterized protein LOC664422 [Tribolium castaneum]>gi|270009553|gb|EFA06001.1| hypothetical protein TcasGA2_TC008827 [Tribolium castaneum] -- -- -- -- -- K04402 GADD45 growth arrest and DNA-damage-inducible protein http://www.genome.jp/dbget-bin/www_bget?ko:K04402 -- -- -- -- -- -- GO:0006950//GO:0051726 response to stress//regulation of cell cycle -- -- GO:0005634 nucleus -- -- Cluster-8309.40453 BF_2 613.76 6.03 4548 642937750 XP_008198931.1 1336 3.6e-144 PREDICTED: GRAM domain-containing protein 3-like isoform X3 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.55367e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q80TI0 272 3.5e-22 GRAM domain-containing protein 1B OS=Mus musculus GN=Gramd1b PE=2 SV=2 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.40454 BF_2 630.20 6.36 4430 642937748 XP_008198930.1 1378 4.7e-149 PREDICTED: GRAM domain-containing protein 3-like isoform X2 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.51304e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q3KR37 272 3.4e-22 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.40455 BF_2 374.38 4.15 4061 642937748 XP_008198930.1 1378 4.3e-149 PREDICTED: GRAM domain-containing protein 3-like isoform X2 [Tribolium castaneum] 642937751 XM_001814094.2 38 1.38598e-07 PREDICTED: Tribolium castaneum GRAM domain-containing protein 3-like (LOC100141873), transcript variant X4, mRNA -- -- -- -- Q3KR37 272 3.1e-22 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 PF01277 Oleosin -- -- -- -- GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.40457 BF_2 98.41 0.98 4475 91087897 XP_970459.1 859 7.2e-89 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270012016|gb|EFA08464.1| hypothetical protein TcasGA2_TC006113 [Tribolium castaneum] 642930872 XM_965366.2 96 8.75495e-40 PREDICTED: Tribolium castaneum arrestin domain-containing protein 3 (LOC659027), mRNA -- -- -- -- Q4KM31 225 9.7e-17 LIM domain-containing protein 2 OS=Rattus norvegicus GN=Limd2 PE=2 SV=1 PF11808//PF05495//PF00412 Domain of unknown function (DUF3329)//CHY zinc finger//LIM domain GO:0016310 phosphorylation GO:0004673//GO:0008270 protein histidine kinase activity//zinc ion binding GO:0009365 protein histidine kinase complex -- -- Cluster-8309.40458 BF_2 11.55 0.31 1829 189236914 XP_969111.2 732 1.6e-74 PREDICTED: alpha-(1,6)-fucosyltransferase [Tribolium castaneum]>gi|270006336|gb|EFA02784.1| hypothetical protein TcasGA2_TC008521 [Tribolium castaneum] -- -- -- -- -- K00717 FUT8 glycoprotein 6-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00717 Q9VYV5 287 2.6e-24 Alpha-(1,6)-fucosyltransferase OS=Drosophila melanogaster GN=FucT6 PE=1 SV=1 PF03462//PF09807//PF03938 PCRF domain//Elongation complex protein 6//Outer membrane protein (OmpH-like) GO:0006415//GO:0006449 translational termination//regulation of translational termination GO:0051082//GO:0016149 unfolded protein binding//translation release factor activity, codon specific GO:0005840//GO:0018444//GO:0005737//GO:0033588 ribosome//translation release factor complex//cytoplasm//Elongator holoenzyme complex KOG3705 Glycoprotein 6-alpha-L-fucosyltransferase Cluster-8309.40459 BF_2 613.93 3.68 7265 189239910 XP_001811161.1 2656 4.9e-297 PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|642931213|ref|XP_008196486.1| PREDICTED: uncharacterized protein LOC100142394 [Tribolium castaneum]>gi|270012115|gb|EFA08563.1| hypothetical protein TcasGA2_TC006218 [Tribolium castaneum] 642931212 XM_008198264.1 80 1.11738e-30 PREDICTED: Tribolium castaneum uncharacterized LOC100142394 (LOC100142394), transcript variant X2, mRNA -- -- -- -- P91791 286 1.3e-23 Peptidyl-prolyl cis-trans isomerase OS=Hemicentrotus pulcherrimus PE=2 SV=1 PF00097//PF14634//PF01363//PF00643//PF13639//PF04277//PF00160 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//FYVE zinc finger//B-box zinc finger//Ring finger domain//Oxaloacetate decarboxylase, gamma chain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0006525//GO:0006560//GO:0006090//GO:0071436//GO:0006814//GO:0000413 protein folding//arginine metabolic process//proline metabolic process//pyruvate metabolic process//sodium ion export//sodium ion transport//protein peptidyl-prolyl isomerization GO:0005515//GO:0008948//GO:0003755//GO:0008270//GO:0046872//GO:0015081 protein binding//oxaloacetate decarboxylase activity//peptidyl-prolyl cis-trans isomerase activity//zinc ion binding//metal ion binding//sodium ion transmembrane transporter activity GO:0005622//GO:0016020 intracellular//membrane KOG0865 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.40460 BF_2 1672.15 38.59 2100 91083817 XP_973463.1 1845 1.6e-203 PREDICTED: large neutral amino acids transporter small subunit 2 [Tribolium castaneum]>gi|270006773|gb|EFA03221.1| hypothetical protein TcasGA2_TC013142 [Tribolium castaneum] -- -- -- -- -- K13780 SLC7A5, LAT1 solute carrier family 7 (L-type amino acid transporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13780 Q01650 1148 4.3e-124 Large neutral amino acids transporter small subunit 1 OS=Homo sapiens GN=SLC7A5 PE=1 SV=2 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1287 Amino acid transporters Cluster-8309.40462 BF_2 632.04 12.02 2486 546684670 ERL94287.1 522 4.8e-50 hypothetical protein D910_11568 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NJ15 132 3.3e-06 Proprotein convertase subtilisin/kexin type 5 OS=Branchiostoma californiense GN=PC6 PE=2 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.40463 BF_2 152.50 1.78 3865 332375078 AEE62680.1 1122 2.0e-119 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14457 MOGAT2, MGAT2 2-acylglycerol O-acyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14457 Q3SYC2 664 1.0e-67 2-acylglycerol O-acyltransferase 2 OS=Homo sapiens GN=MOGAT2 PE=1 SV=2 PF03982 Diacylglycerol acyltransferase -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG0831 Acyl-CoA:diacylglycerol acyltransferase (DGAT) Cluster-8309.40465 BF_2 261.16 4.06 2978 91090214 XP_967924.1 1528 1.3e-166 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 652 2.0e-66 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.40467 BF_2 1861.13 50.76 1821 91086561 XP_975997.1 1203 3.8e-129 PREDICTED: phosphoenolpyruvate carboxykinase [GTP] isoform X1 [Tribolium castaneum]>gi|270009775|gb|EFA06223.1| hypothetical protein TcasGA2_TC009072 [Tribolium castaneum] 766927493 XM_011497449.1 59 1.30369e-19 PREDICTED: Ceratosolen solmsi marchali phosphoenolpyruvate carboxykinase [GTP]-like (LOC105360529), mRNA K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 P20007 995 2.0e-106 Phosphoenolpyruvate carboxykinase [GTP] OS=Drosophila melanogaster GN=Pepck PE=2 SV=2 PF00821 Phosphoenolpyruvate carboxykinase GO:0006099//GO:0006094 tricarboxylic acid cycle//gluconeogenesis GO:0005525//GO:0004613//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase (GTP) activity//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.40468 BF_2 23.26 0.82 1475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40469 BF_2 341.33 2.76 5468 189239886 XP_969203.2 1791 7.5e-197 PREDICTED: protein tweety [Tribolium castaneum] 642931168 XM_964110.3 243 2.05626e-121 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1074 4.2e-115 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40470 BF_2 2044.05 37.64 2559 642914669 XP_008190307.1 2276 2.0e-253 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6P2X9 431 7.2e-41 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF01306//PF07690 LacY proton/sugar symporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.40471 BF_2 517.05 5.31 4359 642922337 XP_008193118.1 1681 3.4e-184 PREDICTED: four and a half LIM domains protein 2 isoform X4 [Tribolium castaneum] 642922336 XM_008194896.1 488 0 PREDICTED: Tribolium castaneum four and a half LIM domains protein 2 (LOC661300), transcript variant X4, mRNA K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 1001 9.9e-107 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF00412//PF07562 LIM domain//Nine Cysteines Domain of family 3 GPCR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0008270 G-protein coupled receptor activity//zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.40472 BF_2 189.15 3.13 2812 270007215 EFA03663.1 306 6.0e-25 hypothetical protein TcasGA2_TC013758 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40477 BF_2 2949.05 60.45 2328 642936150 XP_975125.2 939 2.0e-98 PREDICTED: zinc transporter ZIP13 homolog [Tribolium castaneum] -- -- -- -- -- K14719 SLC39A13, ZIP13 solute carrier family 39 (zinc transporter), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K14719 Q9VAF0 594 8.2e-60 Zinc transporter ZIP13 homolog OS=Drosophila melanogaster GN=Zip99C PE=2 SV=1 PF03352//PF02535 Methyladenine glycosylase//ZIP Zinc transporter GO:0030001//GO:0055085//GO:0006284 metal ion transport//transmembrane transport//base-excision repair GO:0008725//GO:0046873 DNA-3-methyladenine glycosylase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.40478 BF_2 274.68 1.67 7155 91090606 XP_973086.1 645 7.5e-64 PREDICTED: peroxisomal membrane protein PEX14 [Tribolium castaneum] -- -- -- -- -- K13343 PEX14 peroxin-14 http://www.genome.jp/dbget-bin/www_bget?ko:K13343 Q642G4 224 2.0e-16 Peroxisomal membrane protein PEX14 OS=Rattus norvegicus GN=Pex14 PE=1 SV=1 PF05008 Vesicle transport v-SNARE protein N-terminus GO:0006886 intracellular protein transport -- -- GO:0016020 membrane KOG2629 Peroxisomal membrane anchor protein (peroxin) Cluster-8309.40479 BF_2 4528.26 98.72 2206 478263357 ENN81733.1 230 3.1e-16 hypothetical protein YQE_01872, partial [Dendroctonus ponderosae]>gi|546681305|gb|ERL91419.1| hypothetical protein D910_08751 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0032222//GO:0030431//GO:1903818 regulation of synaptic transmission, cholinergic//sleep//positive regulation of voltage-gated potassium channel activity GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.40480 BF_2 459.14 7.86 2732 642914891 XP_008190433.1 1675 1.1e-183 PREDICTED: CTL-like protein 2 isoform X2 [Tribolium castaneum] 620966641 XM_007658441.1 44 4.28874e-11 PREDICTED: Ornithorhynchus anatinus choline transporter-like protein 2 (LOC100086451), mRNA K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q7PRJ0 1269 5.2e-138 CTL-like protein 2 OS=Anopheles gambiae GN=AGAP010343 PE=3 SV=4 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.40485 BF_2 123.57 1.22 4538 642919813 XP_008192079.1 4520 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Tribolium castaneum] 642919812 XM_008193857.1 725 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X4, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1844 1.8e-204 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF05445//PF00069//PF06293//PF07714 Poxvirus serine/threonine protein kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.40489 BF_2 156.99 0.65 10416 642925077 XP_008194160.1 2597 4.9e-290 PREDICTED: suppressor of presenilin protein 4 isoform X4 [Tribolium castaneum] 462390187 APGK01018906.1 55 1.26696e-16 Dendroctonus ponderosae Seq01018916, whole genome shotgun sequence -- -- -- -- Q96IR2 252 1.7e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF02196//PF00715//PF05792//PF13465//PF00096//PF04988 Raf-like Ras-binding domain//Interleukin 2//Candida agglutinin-like (ALS)//Zinc-finger double domain//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95) GO:0007165//GO:0040007//GO:0008283//GO:0007155//GO:0006955 signal transduction//growth//cell proliferation//cell adhesion//immune response GO:0003677//GO:0005057//GO:0008083//GO:0046872//GO:0005134 DNA binding//receptor signaling protein activity//growth factor activity//metal ion binding//interleukin-2 receptor binding GO:0005634//GO:0005576//GO:0005893 nucleus//extracellular region//interleukin-2 receptor complex -- -- Cluster-8309.40490 BF_2 185.44 1.11 7253 642929299 XP_008195778.1 9649 0.0e+00 PREDICTED: dnaJ homolog subfamily C member 13 [Tribolium castaneum] -- -- -- -- -- K09533 DNAJC13 DnaJ homolog subfamily C member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09533 O75165 6488 0.0e+00 DnaJ homolog subfamily C member 13 OS=Homo sapiens GN=DNAJC13 PE=1 SV=5 PF00514//PF08040//PF00647//PF10152//PF00223 Armadillo/beta-catenin-like repeat//MNLL subunit//Elongation factor 1 gamma, conserved domain//Predicted coiled-coil domain-containing protein (DUF2360)//Photosystem I psaA/psaB protein GO:0006414//GO:0015979//GO:0006448//GO:0006118 translational elongation//photosynthesis//regulation of translational elongation//obsolete electron transport GO:0005515//GO:0003954//GO:0003746 protein binding//NADH dehydrogenase activity//translation elongation factor activity GO:0016021//GO:0009522//GO:0005840//GO:0071203//GO:0009579//GO:0005739 integral component of membrane//photosystem I//ribosome//WASH complex//thylakoid//mitochondrion KOG1789 Endocytosis protein RME-8, contains DnaJ domain Cluster-8309.40491 BF_2 3100.65 15.25 8791 642933622 XP_008197499.1 5260 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [Tribolium castaneum]>gi|270011314|gb|EFA07762.1| hypothetical protein TcasGA2_TC005316 [Tribolium castaneum] 641702319 XM_008141598.1 150 1.65426e-69 PREDICTED: Eptesicus fuscus ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant X3, mRNA K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 3619 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 PF13414//PF00443//PF02430//PF00917//PF15499//PF00240 TPR repeat//Ubiquitin carboxyl-terminal hydrolase//Apical membrane antigen 1//MATH domain//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Ubiquitin family GO:0009405//GO:0016579//GO:0006511 pathogenesis//protein deubiquitination//ubiquitin-dependent protein catabolic process GO:0005515//GO:0070140//GO:0032183//GO:0036459//GO:0004221 protein binding//SUMO-specific isopeptidase activity//SUMO binding//ubiquitinyl hydrolase activity//obsolete ubiquitin thiolesterase activity GO:0016020 membrane KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.40492 BF_2 116.03 2.41 2300 478253101 ENN73474.1 189 1.8e-11 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40493 BF_2 622.32 3.32 8122 478251011 ENN71492.1 1218 3.1e-130 hypothetical protein YQE_11788, partial [Dendroctonus ponderosae] -- -- -- -- -- K09592 EGLN, HPH hypoxia-inducible factor prolyl hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K09592 Q91YE3 670 4.4e-68 Egl nine homolog 1 OS=Mus musculus GN=Egln1 PE=2 SV=2 PF13640//PF01254 2OG-Fe(II) oxygenase superfamily//Nuclear transition protein 2 GO:0055114//GO:0007283 oxidation-reduction process//spermatogenesis GO:0003677//GO:0016491 DNA binding//oxidoreductase activity GO:0005634//GO:0000786 nucleus//nucleosome KOG3710 EGL-Nine (EGLN) protein Cluster-8309.40494 BF_2 626.00 18.25 1722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40495 BF_2 621.93 9.54 3015 189238048 XP_001811309.1 1728 8.3e-190 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 2.1e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF01370//PF01073//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0008210 C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//estrogen metabolic process GO:0080019//GO:0003854//GO:0050662//GO:0003824//GO:0016616 fatty-acyl-CoA reductase (alcohol-forming) activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.40497 BF_2 469.80 4.19 4979 642924146 XP_008194026.1 3330 0.0e+00 PREDICTED: signal transducer and activator of transcription 5B isoform X2 [Tribolium castaneum] 642924145 XM_008195804.1 442 0 PREDICTED: Tribolium castaneum signal-transducer and activator of transcription protein (LOC657965), transcript variant X3, mRNA K11224 STAT5B signal transducer and activator of transcription 5B http://www.genome.jp/dbget-bin/www_bget?ko:K11224 Q9TUZ0 1741 1.8e-192 Signal transducer and activator of transcription 5B OS=Sus scrofa GN=STAT5B PE=2 SV=1 PF02864//PF01017//PF02865 STAT protein, DNA binding domain//STAT protein, all-alpha domain//STAT protein, protein interaction domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0004871 transcription factor activity, sequence-specific DNA binding//signal transducer activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40500 BF_2 79.09 1.44 2584 642917177 XP_008191151.1 756 3.6e-77 PREDICTED: pangolin isoform X3 [Tribolium castaneum] 642917176 XM_008192929.1 411 0 PREDICTED: Tribolium castaneum pangolin (Pan), transcript variant X3, mRNA K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 P91943 333 1.7e-29 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.40501 BF_2 357.82 8.96 1958 642917173 XP_008191149.1 1345 1.4e-145 PREDICTED: pangolin isoform X1 [Tribolium castaneum] 642917176 XM_008192929.1 645 0 PREDICTED: Tribolium castaneum pangolin (Pan), transcript variant X3, mRNA K04491 TCF7L2 transcription factor 7-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04491 P91943 664 5.3e-68 Protein pangolin, isoforms A/H/I/S OS=Drosophila melanogaster GN=pan PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3248 Transcription factor TCF-4 Cluster-8309.40503 BF_2 99.03 4.21 1272 270003498 EEZ99945.1 1414 9.0e-154 hypothetical protein TcasGA2_TC002741 [Tribolium castaneum] -- -- -- -- -- K12316 GAA lysosomal alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12316 P70699 916 2.1e-97 Lysosomal alpha-glucosidase OS=Mus musculus GN=Gaa PE=1 SV=2 PF01055//PF03498 Glycosyl hydrolases family 31//Cytolethal distending toxin A/C domain GO:0005975//GO:0009405 carbohydrate metabolic process//pathogenesis GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.40504 BF_2 491.00 5.89 3773 91092740 XP_973214.1 1339 1.3e-144 PREDICTED: alpha/beta hydrolase domain-containing protein 17B [Tribolium castaneum]>gi|270014884|gb|EFA11332.1| hypothetical protein TcasGA2_TC010871 [Tribolium castaneum] 642911451 XM_968121.3 343 3.63872e-177 PREDICTED: Tribolium castaneum alpha/beta hydrolase domain-containing protein 17B (LOC661993), mRNA -- -- -- -- Q7ZVZ7 1114 6.7e-120 Alpha/beta hydrolase domain-containing protein 17C OS=Danio rerio GN=abhd17c PE=2 SV=1 PF02230//PF00326//PF16929//PF01738 Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Accessory Sec system GspB-transporter//Dienelactone hydrolase family GO:0015031//GO:0006508 protein transport//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.40506 BF_2 31.58 0.51 2865 642938354 XP_008198798.1 765 3.7e-78 PREDICTED: peptidyl-prolyl cis-trans isomerase G [Tribolium castaneum] 645259408 XM_008237125.1 62 4.43708e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.3e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF06213//PF02862//PF02724//PF03522//PF02535//PF06459//PF00160//PF08496//PF09507//PF05132//PF01080//PF03839 Cobalamin biosynthesis protein CobT//DDHD domain//CDC45-like protein//Solute carrier family 12//ZIP Zinc transporter//Ryanodine Receptor TM 4-6//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Peptidase family S49 N-terminal//DNA polymerase subunit Cdc27//RNA polymerase III RPC4//Presenilin//Translocation protein Sec62 GO:0006144//GO:0006351//GO:0030001//GO:0006457//GO:0006811//GO:0006206//GO:0006810//GO:0006816//GO:0015031//GO:0006874//GO:0006383//GO:0000413//GO:0006270//GO:0055085//GO:0009236//GO:0006260 purine nucleobase metabolic process//transcription, DNA-templated//metal ion transport//protein folding//ion transport//pyrimidine nucleobase metabolic process//transport//calcium ion transport//protein transport//cellular calcium ion homeostasis//transcription from RNA polymerase III promoter//protein peptidyl-prolyl isomerization//DNA replication initiation//transmembrane transport//cobalamin biosynthetic process//DNA replication GO:0005219//GO:0003677//GO:0003899//GO:0004252//GO:0008565//GO:0005215//GO:0004190//GO:0046872//GO:0046873//GO:0003755 ryanodine-sensitive calcium-release channel activity//DNA binding//DNA-directed RNA polymerase activity//serine-type endopeptidase activity//protein transporter activity//transporter activity//aspartic-type endopeptidase activity//metal ion binding//metal ion transmembrane transporter activity//peptidyl-prolyl cis-trans isomerase activity GO:0005634//GO:0005886//GO:0016020//GO:0016021//GO:0005622//GO:0005730//GO:0005666 nucleus//plasma membrane//membrane//integral component of membrane//intracellular//nucleolus//DNA-directed RNA polymerase III complex KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.40507 BF_2 124.76 1.62 3518 642931467 XP_966826.3 1593 4.4e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 1.3e-19 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.40508 BF_2 43.57 0.46 4274 91093306 XP_967617.1 1066 6.8e-113 PREDICTED: putative protein FAM10A4 [Tribolium castaneum]>gi|270014189|gb|EFA10637.1| hypothetical protein TcasGA2_TC016274 [Tribolium castaneum] -- -- -- -- -- K09560 ST13 suppressor of tumorigenicity protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09560 Q5ZLF0 702 4.5e-72 Hsc70-interacting protein OS=Gallus gallus GN=ST13 PE=2 SV=1 PF00522//PF01835//PF13414//PF13176//PF04194//PF00515//PF13374//PF13371//PF13174//PF13181 VPR/VPX protein//MG2 domain//TPR repeat//Tetratricopeptide repeat//Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0004866//GO:0005515 endopeptidase inhibitor activity//protein binding GO:0005737//GO:0042025 cytoplasm//host cell nucleus KOG1308 Hsp70-interacting protein Hip/Transient component of progesterone receptor complexes and an Hsp70-binding protein Cluster-8309.40509 BF_2 27.00 0.85 1615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01003 Flavivirus capsid protein C -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.40510 BF_2 157.12 1.78 3987 642923393 XP_008193730.1 1613 2.4e-176 PREDICTED: facilitated trehalose transporter Tret1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 457 1.1e-43 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF11789//PF07690//PF12678//PF14634//PF00097//PF13639//PF16685//PF12861//PF01589 Sugar (and other) transporter//Zinc-finger of the MIZ type in Nse subunit//Major Facilitator Superfamily//RING-H2 zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger//Alphavirus E1 glycoprotein GO:0016567//GO:0055085 protein ubiquitination//transmembrane transport GO:0046872//GO:0004252//GO:0008270//GO:0061630//GO:0004842//GO:0005515//GO:0022857 metal ion binding//serine-type endopeptidase activity//zinc ion binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding//transmembrane transporter activity GO:0055036//GO:0005680//GO:0019028//GO:0016021 virion membrane//anaphase-promoting complex//viral capsid//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.40512 BF_2 709.09 3.80 8098 189241962 XP_968788.2 787 2.9e-80 PREDICTED: remodeling and spacing factor 1-like [Tribolium castaneum] -- -- -- -- -- K11657 RSF1 remodeling and spacing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11657 Q96T23 382 1.1e-34 Remodeling and spacing factor 1 OS=Homo sapiens GN=RSF1 PE=1 SV=2 PF01428//PF10404//PF00628 AN1-like Zinc finger//Rad4 beta-hairpin domain 2//PHD-finger -- -- GO:0003677//GO:0008270//GO:0005515 DNA binding//zinc ion binding//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.40514 BF_2 658.47 14.91 2135 642921619 XP_008192449.1 547 5.2e-53 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|642921621|ref|XP_008192450.1| PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 293 6.0e-25 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.40515 BF_2 397.00 6.77 2739 642912091 XP_008200799.1 786 1.3e-80 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] 642912098 XM_008202582.1 273 2.15306e-138 PREDICTED: Tribolium castaneum ecdysone-induced protein 74EF (LOC655028), transcript variant X5, mRNA K09428 ELF1_2_4 E74-like factor 1/2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K09428 P11536 617 2.1e-62 Ecdysone-induced protein 74EF isoform B OS=Drosophila melanogaster GN=Eip74EF PE=2 SV=2 PF00178 Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3804 Transcription factor NERF and related proteins, contain ETS domain Cluster-8309.40516 BF_2 38.67 1.06 1807 642934737 XP_008197792.1 1218 6.8e-131 PREDICTED: uncharacterized protein LOC103314212 [Tribolium castaneum] 768447197 XM_011567278.1 53 2.79986e-16 PREDICTED: Plutella xylostella vegetative cell wall protein gp1 (LOC105395329), mRNA -- -- -- -- -- -- -- -- PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40517 BF_2 126.90 1.19 4741 642934737 XP_008197792.1 1348 1.5e-145 PREDICTED: uncharacterized protein LOC103314212 [Tribolium castaneum] 768447197 XM_011567278.1 52 2.67297e-15 PREDICTED: Plutella xylostella vegetative cell wall protein gp1 (LOC105395329), mRNA -- -- -- -- -- -- -- -- PF00057//PF00599 Low-density lipoprotein receptor domain class A//Influenza Matrix protein (M2) GO:0015992 proton transport GO:0005515//GO:0015078 protein binding//hydrogen ion transmembrane transporter activity GO:0033644//GO:0055036 host cell membrane//virion membrane -- -- Cluster-8309.40518 BF_2 48.78 1.64 1530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40519 BF_2 1968.28 11.92 7196 642936633 XP_008198516.1 3023 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936632 XM_008200294.1 364 0 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X1, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 2.3e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF02262//PF08702//PF04513//PF01496//PF04111//PF06009//PF15182 CBL proto-oncogene N-terminal domain 1//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//V-type ATPase 116kDa subunit family//Autophagy protein Apg6//Laminin Domain II//Otospiralin GO:0015991//GO:0030168//GO:0007155//GO:0007165//GO:0007605//GO:0006914//GO:0051258//GO:0007166//GO:0015992 ATP hydrolysis coupled proton transport//platelet activation//cell adhesion//signal transduction//sensory perception of sound//autophagy//protein polymerization//cell surface receptor signaling pathway//proton transport GO:0004871//GO:0030674//GO:0005198//GO:0015078//GO:0005102 signal transducer activity//protein binding, bridging//structural molecule activity//hydrogen ion transmembrane transporter activity//receptor binding GO:0005634//GO:0019031//GO:0033179//GO:0019028//GO:0005577 nucleus//viral envelope//proton-transporting V-type ATPase, V0 domain//viral capsid//fibrinogen complex -- -- Cluster-8309.40521 BF_2 28.41 1.65 1006 642922198 XP_008193058.1 407 4.2e-37 PREDICTED: patronin isoform X5 [Tribolium castaneum] -- -- -- -- -- K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 200 1.7e-14 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40523 BF_2 97.00 0.79 5425 642926303 XP_008194869.1 1059 5.6e-112 PREDICTED: GDNF-inducible zinc finger protein 1-like [Tribolium castaneum]>gi|270008503|gb|EFA04951.1| hypothetical protein TcasGA2_TC015019 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJU3 323 5.1e-28 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF00096//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40524 BF_2 4083.45 9.31 18629 612342210 AHW99830.1 17783 0.0e+00 ryanodine receptor [Leptinotarsa decemlineata] 612342209 KF734670.1 1032 0 Leptinotarsa decemlineata ryanodine receptor mRNA, complete cds K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 14917 0.0e+00 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 PF00520//PF00487//PF06423//PF06459//PF00622//PF01365//PF13499//PF13833//PF02815 Ion transport protein//Fatty acid desaturase//GWT1//Ryanodine Receptor TM 4-6//SPRY domain//RIH domain//EF-hand domain pair//EF-hand domain pair//MIR domain GO:0006629//GO:0006811//GO:0006506//GO:0070588//GO:0055085//GO:0006816//GO:0006874 lipid metabolic process//ion transport//GPI anchor biosynthetic process//calcium ion transmembrane transport//transmembrane transport//calcium ion transport//cellular calcium ion homeostasis GO:0005515//GO:0005219//GO:0016746//GO:0005262//GO:0005509//GO:0005216 protein binding//ryanodine-sensitive calcium-release channel activity//transferase activity, transferring acyl groups//calcium channel activity//calcium ion binding//ion channel activity GO:0005789//GO:0016020//GO:0016021//GO:0005622 endoplasmic reticulum membrane//membrane//integral component of membrane//intracellular KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.40526 BF_2 113.56 3.67 1581 -- -- -- -- -- 642928448 XM_008195568.1 132 2.965e-60 PREDICTED: Tribolium castaneum transcriptional-regulating factor 1 (LOC103313127), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40527 BF_2 307.01 1.55 8583 270012359 EFA08807.1 1919 1.7e-211 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.3e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF00098//PF04564//PF14634//PF02817//PF00097//PF01588//PF08783//PF00198//PF13639 Zinc knuckle//U-box domain//zinc-RING finger domain//e3 binding domain//Zinc finger, C3HC4 type (RING finger)//Putative tRNA binding domain//DWNN domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Ring finger domain GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0005515//GO:0000049//GO:0004842//GO:0016746//GO:0003676//GO:0008270//GO:0046872 protein binding//tRNA binding//ubiquitin-protein transferase activity//transferase activity, transferring acyl groups//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.40529 BF_2 168.24 0.97 7540 642939432 XP_008200388.1 4207 0.0e+00 PREDICTED: pumilio homolog 2 isoform X1 [Tribolium castaneum] 642939441 XM_008202171.1 724 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X6, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806//PF02422 CPL (NUC119) domain//Pumilio-family RNA binding repeat//Keratin -- -- GO:0003723//GO:0005200 RNA binding//structural constituent of cytoskeleton GO:0005882//GO:0005856 intermediate filament//cytoskeleton KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.40530 BF_2 246.30 3.19 3520 329350997 AEB91339.1 1370 3.2e-148 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- K00115 E1.1.5.9 glucose dehydrogenase (acceptor) http://www.genome.jp/dbget-bin/www_bget?ko:K00115 P18173 637 1.3e-64 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF07992//PF05834//PF00732//PF01266//PF05199//PF02254 Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//potassium ion transport GO:0016614//GO:0016705//GO:0050660//GO:0016491 oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.40531 BF_2 332.30 5.04 3046 642916135 XP_008190901.1 765 3.9e-78 PREDICTED: PQ-loop repeat-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N755 308 1.6e-26 PQ-loop repeat-containing protein 3 OS=Homo sapiens GN=PQLC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.40532 BF_2 1165.23 22.91 2415 270012526 EFA08974.1 251 1.2e-18 hypothetical protein TcasGA2_TC006681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40533 BF_2 2735.82 24.54 4951 688589261 XP_009290233.1 283 4.9e-22 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 169 2.54692e-80 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q9UII5 263 4.2e-21 Zinc finger protein 107 OS=Homo sapiens GN=ZNF107 PE=2 SV=1 PF13465//PF00076//PF16367//PF13912//PF02892//PF00096//PF05495//PF02207//PF05478 Zinc-finger double domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//CHY zinc finger//Putative zinc finger in N-recognin (UBR box)//Prominin -- -- GO:0046872//GO:0003676//GO:0003677//GO:0008270 metal ion binding//nucleic acid binding//DNA binding//zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.40534 BF_2 660.90 5.62 5203 270007741 EFA04189.1 2015 7.5e-223 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 672078086 XM_006252000.2 43 2.95627e-10 PREDICTED: Rattus norvegicus ring finger protein 31 (Rnf31), transcript variant X1, mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 897 1.3e-94 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF05121//PF02845 Gas vesicle protein K//CUE domain GO:0031412 gas vesicle organization GO:0005515 protein binding -- -- KOG1812 Predicted E3 ubiquitin ligase Cluster-8309.40536 BF_2 1519.03 16.68 4097 91077414 XP_975386.1 1918 1.0e-211 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 5.3e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF12634//PF00516//PF06723//PF02782//PF13414//PF15281 Inheritance of peroxisomes protein 1//Envelope glycoprotein GP120//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//TPR repeat//Consortin C-terminus GO:0042998//GO:0006457//GO:0005975//GO:0045033//GO:0000902 positive regulation of Golgi to plasma membrane protein transport//protein folding//carbohydrate metabolic process//peroxisome inheritance//cell morphogenesis GO:0005515//GO:0071253//GO:0005524//GO:0016773//GO:0051082 protein binding//connexin binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//unfolded protein binding GO:0005802//GO:0019031//GO:0005780 trans-Golgi network//viral envelope//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.40537 BF_2 175.96 1.49 5240 357619286 EHJ71921.1 431 3.6e-39 hypothetical protein KGM_05158 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.40538 BF_2 156.56 12.92 794 91082799 XP_967823.1 410 1.5e-37 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase hpo-8 [Tribolium castaneum]>gi|270007103|gb|EFA03551.1| hypothetical protein TcasGA2_TC013556 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 300 3.5e-26 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40539 BF_2 551.45 15.86 1742 91082799 XP_967823.1 427 3.5e-39 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase hpo-8 [Tribolium castaneum]>gi|270007103|gb|EFA03551.1| hypothetical protein TcasGA2_TC013556 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 O17040 273 1.0e-22 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 OS=Caenorhabditis elegans GN=hpo-8 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40540 BF_2 44.56 0.55 3655 91082799 XP_967823.1 427 7.3e-39 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase hpo-8 [Tribolium castaneum]>gi|270007103|gb|EFA03551.1| hypothetical protein TcasGA2_TC013556 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 O17040 273 2.2e-22 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase hpo-8 OS=Caenorhabditis elegans GN=hpo-8 PE=3 SV=2 PF09768 Peptidase M76 family -- -- GO:0004222 metalloendopeptidase activity -- -- KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40541 BF_2 55.02 1.01 2562 91082797 XP_967743.1 383 6.5e-34 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 261 3.7e-21 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.40545 BF_2 36.21 0.35 4672 642918982 XP_008191684.1 4673 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.45611e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF05109//PF00122 Herpes virus major outer envelope glycoprotein (BLLF1)//E1-E2 ATPase GO:0019058 viral life cycle GO:0046872//GO:0000166 metal ion binding//nucleotide binding GO:0019031 viral envelope KOG0206 P-type ATPase Cluster-8309.40546 BF_2 310.00 16.15 1090 478255733 ENN75942.1 519 4.7e-50 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 222 5.3e-17 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.40550 BF_2 4446.09 74.10 2797 91087957 XP_972849.1 2969 0.0e+00 PREDICTED: eukaryotic translation initiation factor 3 subunit B [Tribolium castaneum]>gi|270011918|gb|EFA08366.1| hypothetical protein TcasGA2_TC006009 [Tribolium castaneum] 759033163 XM_011349720.1 192 2.34385e-93 PREDICTED: Cerapachys biroi eukaryotic translation initiation factor 3 subunit B (LOC105285460), mRNA K03253 EIF3B translation initiation factor 3 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K03253 Q1HDZ5 2322 4.2e-260 Eukaryotic translation initiation factor 3 subunit B OS=Bombyx mori GN=eIF3-S9 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0000166//GO:0003676//GO:0003743 nucleotide binding//nucleic acid binding//translation initiation factor activity GO:0005840//GO:0005737 ribosome//cytoplasm KOG2314 Translation initiation factor 3, subunit b (eIF-3b) Cluster-8309.40553 BF_2 1860.39 22.71 3714 478251310 ENN71778.1 2248 5.2e-250 hypothetical protein YQE_11513, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68FA7 147 8.9e-08 E3 ubiquitin-protein ligase MARCH3 OS=Xenopus tropicalis GN=march3 PE=2 SV=1 PF03186//PF00737//PF12906//PF04434 CobD/Cbib protein//Photosystem II 10 kDa phosphoprotein//RING-variant domain//SWIM zinc finger GO:0009236//GO:0015979//GO:0050821 cobalamin biosynthetic process//photosynthesis//protein stabilization GO:0008270//GO:0042301//GO:0048472 zinc ion binding//phosphate ion binding//threonine-phosphate decarboxylase activity GO:0009523//GO:0016020//GO:0016021 photosystem II//membrane//integral component of membrane KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.40555 BF_2 1245.09 24.71 2395 91093675 XP_969585.1 1262 7.2e-136 PREDICTED: traB domain-containing protein [Tribolium castaneum]>gi|270008075|gb|EFA04523.1| hypothetical protein TcasGA2_TC016318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99JY4 634 1.9e-64 TraB domain-containing protein OS=Mus musculus GN=Trabd PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2860 Uncharacterized conserved protein, contains TraB domain Cluster-8309.40556 BF_2 2599.09 24.54 4718 688589261 XP_009290233.1 275 4.0e-21 PREDICTED: zinc finger and SCAN domain containing 2-like isoform X1 [Danio rerio] 817210508 XM_012425923.1 150 8.85045e-70 PREDICTED: Orussus abietinus uncharacterized LOC105700249 (LOC105700249), mRNA K09203 EGR1 early growth response protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09203 Q99676 246 3.8e-19 Zinc finger protein 184 OS=Homo sapiens GN=ZNF184 PE=1 SV=4 PF05495//PF13465//PF00096//PF13912//PF02892//PF03868//PF02207 CHY zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Ribosomal protein L6, N-terminal domain//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003677//GO:0046872//GO:0008270//GO:0003735 DNA binding//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.40557 BF_2 628.90 3.18 8566 642933622 XP_008197499.1 5274 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [Tribolium castaneum]>gi|270011314|gb|EFA07762.1| hypothetical protein TcasGA2_TC005316 [Tribolium castaneum] 641702319 XM_008141598.1 150 1.61174e-69 PREDICTED: Eptesicus fuscus ubiquitin specific peptidase 7 (herpes virus-associated) (USP7), transcript variant X3, mRNA K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 3625 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 PF00443//PF15499//PF02430//PF00917//PF00240 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Apical membrane antigen 1//MATH domain//Ubiquitin family GO:0009405//GO:0006511//GO:0016579 pathogenesis//ubiquitin-dependent protein catabolic process//protein deubiquitination GO:0036459//GO:0070140//GO:0032183//GO:0005515//GO:0004221 ubiquitinyl hydrolase activity//SUMO-specific isopeptidase activity//SUMO binding//protein binding//obsolete ubiquitin thiolesterase activity GO:0016020 membrane KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.40560 BF_2 248.90 0.81 13082 189235004 XP_970036.2 3148 0.0e+00 PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [Tribolium castaneum]>gi|270003924|gb|EFA00372.1| hypothetical protein TcasGA2_TC003215 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 Q6IR34 1569 4.1e-172 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 PF05194//PF13181//PF07714//PF10579//PF00069//PF13176//PF13414//PF02104//PF13374//PF04692//PF00515//PF00620//PF06293//PF02188 UreE urease accessory protein, C-terminal domain//Tetratricopeptide repeat//Protein tyrosine kinase//Rapsyn N-terminal myristoylation and linker region//Protein kinase domain//Tetratricopeptide repeat//TPR repeat//SURF1 family//Tetratricopeptide repeat//Platelet-derived growth factor, N terminal region//Tetratricopeptide repeat//RhoGAP domain//Lipopolysaccharide kinase (Kdo/WaaP) family//GoLoco motif GO:0040007//GO:0008283//GO:0019627//GO:0007165//GO:0006461//GO:0006468//GO:0007268 growth//cell proliferation//urea metabolic process//signal transduction//protein complex assembly//protein phosphorylation//synaptic transmission GO:0030695//GO:0016773//GO:0004672//GO:0043495//GO:0008083//GO:0033130//GO:0005515//GO:0016151//GO:0005524 GTPase regulator activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein anchor//growth factor activity//acetylcholine receptor binding//protein binding//nickel cation binding//ATP binding GO:0016020 membrane KOG1563 Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase Cluster-8309.40561 BF_2 908.49 2.98 13026 189235004 XP_970036.2 3148 0.0e+00 PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [Tribolium castaneum]>gi|270003924|gb|EFA00372.1| hypothetical protein TcasGA2_TC003215 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 Q6IR34 1569 4.0e-172 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 PF05194//PF10579//PF13181//PF07714//PF00069//PF13176//PF02104//PF13414//PF13374//PF04692//PF00515//PF02188//PF06293//PF00620 UreE urease accessory protein, C-terminal domain//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Protein tyrosine kinase//Protein kinase domain//Tetratricopeptide repeat//SURF1 family//TPR repeat//Tetratricopeptide repeat//Platelet-derived growth factor, N terminal region//Tetratricopeptide repeat//GoLoco motif//Lipopolysaccharide kinase (Kdo/WaaP) family//RhoGAP domain GO:0007165//GO:0006461//GO:0007268//GO:0006468//GO:0040007//GO:0008283//GO:0019627 signal transduction//protein complex assembly//synaptic transmission//protein phosphorylation//growth//cell proliferation//urea metabolic process GO:0005524//GO:0030695//GO:0016773//GO:0043495//GO:0004672//GO:0008083//GO:0033130//GO:0005515//GO:0016151 ATP binding//GTPase regulator activity//phosphotransferase activity, alcohol group as acceptor//protein anchor//protein kinase activity//growth factor activity//acetylcholine receptor binding//protein binding//nickel cation binding GO:0016020 membrane KOG1563 Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase Cluster-8309.40562 BF_2 860.97 2.81 13127 189235004 XP_970036.2 3148 0.0e+00 PREDICTED: arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 [Tribolium castaneum]>gi|270003924|gb|EFA00372.1| hypothetical protein TcasGA2_TC003215 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 Q6IR34 1569 4.1e-172 G-protein-signaling modulator 1 OS=Mus musculus GN=Gpsm1 PE=1 SV=3 PF05194//PF10579//PF13181//PF07714//PF00069//PF13176//PF13414//PF02104//PF04692//PF13374//PF00515//PF06293//PF02188//PF00620 UreE urease accessory protein, C-terminal domain//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Protein tyrosine kinase//Protein kinase domain//Tetratricopeptide repeat//TPR repeat//SURF1 family//Platelet-derived growth factor, N terminal region//Tetratricopeptide repeat//Tetratricopeptide repeat//Lipopolysaccharide kinase (Kdo/WaaP) family//GoLoco motif//RhoGAP domain GO:0006461//GO:0006468//GO:0007268//GO:0007165//GO:0008283//GO:0019627//GO:0040007 protein complex assembly//protein phosphorylation//synaptic transmission//signal transduction//cell proliferation//urea metabolic process//growth GO:0005524//GO:0005515//GO:0016151//GO:0033130//GO:0008083//GO:0043495//GO:0004672//GO:0030695//GO:0016773 ATP binding//protein binding//nickel cation binding//acetylcholine receptor binding//growth factor activity//protein anchor//protein kinase activity//GTPase regulator activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1563 Mitochondrial protein Surfeit 1/SURF1/SHY1, required for expression of cytochrome oxidase Cluster-8309.40563 BF_2 35.20 0.70 2376 91078958 XP_974220.1 498 2.8e-47 PREDICTED: cathepsin B [Tribolium castaneum]>gi|642916227|ref|XP_008190938.1| PREDICTED: cathepsin B [Tribolium castaneum]>gi|270004841|gb|EFA01289.1| cathepsin B precursor [Tribolium castaneum] 642916228 XM_969127.2 108 9.85697e-47 PREDICTED: Tribolium castaneum cathepsin B precursor (LOC663066), transcript variant X2, mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P43233 394 1.3e-36 Cathepsin B OS=Gallus gallus GN=CTSB PE=2 SV=1 PF00112//PF08127 Papain family cysteine protease//Peptidase family C1 propeptide GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.40564 BF_2 1117.51 20.58 2559 642933889 XP_008197555.1 1280 6.3e-138 PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum]>gi|642933891|ref|XP_008197556.1| PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40565 BF_2 72.19 1.06 3126 642933889 XP_008197555.1 1001 1.7e-105 PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum]>gi|642933891|ref|XP_008197556.1| PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40566 BF_2 197.31 10.83 1049 270013573 EFA10021.1 533 1.1e-51 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05049//PF00437//PF00448//PF02421//PF03193//PF03266//PF00005//PF00493//PF04548//PF00071//PF00910//PF08477//PF00735//PF07728//PF01695//PF00158//PF01926//PF00004//PF02367//PF00503//PF01580 Interferon-inducible GTPase (IIGP)//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//Ferrous iron transport protein B//Protein of unknown function, DUF258//NTPase//ABC transporter//MCM2/3/5 family//AIG1 family//Ras family//RNA helicase//Ras of Complex, Roc, domain of DAPkinase//Septin//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//G-protein alpha subunit//FtsK/SpoIIIE family GO:0007264//GO:0002949//GO:0006810//GO:0007165//GO:0006614//GO:0015684//GO:0006260//GO:0006355//GO:0007186 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//transport//signal transduction//SRP-dependent cotranslational protein targeting to membrane//ferrous iron transport//DNA replication//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway GO:0003677//GO:0003723//GO:0015093//GO:0003724//GO:0004871//GO:0005525//GO:0008134//GO:0003924//GO:0031683//GO:0098519//GO:0005524//GO:0019001//GO:0016887//GO:0000166 DNA binding//RNA binding//ferrous iron transmembrane transporter activity//RNA helicase activity//signal transducer activity//GTP binding//transcription factor binding//GTPase activity//G-protein beta/gamma-subunit complex binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//guanyl nucleotide binding//ATPase activity//nucleotide binding GO:0005667//GO:0016020//GO:0016021 transcription factor complex//membrane//integral component of membrane -- -- Cluster-8309.40567 BF_2 13.00 4.57 405 -- -- -- -- -- 462345612 APGK01034602.1 57 3.5148e-19 Dendroctonus ponderosae Seq01034612, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40569 BF_2 2545.51 17.53 6362 270016366 EFA12812.1 562 2.8e-54 hypothetical protein TcasGA2_TC001877 [Tribolium castaneum] 642933104 XM_008199038.1 222 1.12948e-109 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA K13199 SERBP1 plasminogen activator inhibitor 1 RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13199 Q9CY58 178 3.9e-11 Plasminogen activator inhibitor 1 RNA-binding protein OS=Mus musculus GN=Serbp1 PE=1 SV=2 PF03485 Arginyl tRNA synthetase N terminal domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0000166//GO:0004814 ATP binding//nucleotide binding//arginine-tRNA ligase activity GO:0005737 cytoplasm KOG2945 Predicted RNA-binding protein Cluster-8309.40571 BF_2 4826.82 388.42 807 270010810 EFA07258.1 304 2.9e-25 hypothetical protein TcasGA2_TC013289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40572 BF_2 425.95 5.79 3363 642926733 XP_008194990.1 2280 9.1e-254 PREDICTED: protein Malvolio isoform X2 [Tribolium castaneum] -- -- -- -- -- K12347 SLC11A, NRAMP natural resistance-associated macrophage protein http://www.genome.jp/dbget-bin/www_bget?ko:K12347 P49283 1804 5.9e-200 Protein Malvolio OS=Drosophila melanogaster GN=Mvl PE=2 SV=2 PF08089//PF01566//PF15168 Huwentoxin-II family//Natural resistance-associated macrophage protein//Triple QxxK/R motif-containing protein family GO:0006810//GO:0009405 transport//pathogenesis GO:0005215 transporter activity GO:0005576//GO:0016020//GO:0005789 extracellular region//membrane//endoplasmic reticulum membrane KOG1291 Mn2+ and Fe2+ transporters of the NRAMP family Cluster-8309.40575 BF_2 115.89 0.49 10240 642919989 XP_008192156.1 10221 0.0e+00 PREDICTED: teneurin-m isoform X1 [Tribolium castaneum]>gi|642919991|ref|XP_008192157.1| PREDICTED: teneurin-m isoform X1 [Tribolium castaneum]>gi|642919993|ref|XP_008192158.1| PREDICTED: teneurin-m isoform X1 [Tribolium castaneum] 642919996 XM_008193938.1 1698 0 PREDICTED: Tribolium castaneum teneurin-m (LOC664026), transcript variant X5, mRNA -- -- -- -- O61307 8820 0.0e+00 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF07442//PF01436 Ponericin//NHL repeat -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.40576 BF_2 1291.14 6.63 8437 642924582 XP_001814936.2 11294 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 8 isoform X1 [Tribolium castaneum] 780624705 XM_011709832.1 94 2.14242e-38 PREDICTED: Wasmannia auropunctata multiple epidermal growth factor-like domains protein 8 (LOC105462915), mRNA -- -- -- -- P60882 2699 2.4e-303 Multiple epidermal growth factor-like domains protein 8 OS=Mus musculus GN=Megf8 PE=2 SV=2 PF01344//PF01437//PF16622//PF07646//PF07645 Kelch motif//Plexin repeat//zinc-finger C2H2-type//Kelch motif//Calcium-binding EGF domain -- -- GO:0005515//GO:0046872//GO:0005509 protein binding//metal ion binding//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.40579 BF_2 501.85 5.81 3899 642916252 XP_008190947.1 2331 1.3e-259 PREDICTED: intersectin-2-like isoform X1 [Tribolium castaneum] 746842857 XM_011053352.1 94 9.8557e-39 PREDICTED: Acromyrmex echinatior intersectin-1 (LOC105144446), transcript variant X13, mRNA -- -- -- -- Q9NZM3 578 9.9e-58 Intersectin-2 OS=Homo sapiens GN=ITSN2 PE=1 SV=3 PF12763//PF13405//PF00036//PF14604//PF13499//PF00018 Cytoskeletal-regulatory complex EF hand//EF-hand domain//EF hand//Variant SH3 domain//EF-hand domain pair//SH3 domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG1029 Endocytic adaptor protein intersectin Cluster-8309.4058 BF_2 9.00 1.26 586 675390429 KFM83326.1 583 9.5e-58 40S ribosomal protein S18, partial [Stegodyphus mimosarum] 442775364 JQ963186.1 131 3.8088e-60 Spirometra erinaceieuropaei ribosomal protein S18 mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q8ISP0 570 1.3e-57 40S ribosomal protein S18 OS=Branchiostoma belcheri GN=RPS18 PE=2 SV=1 PF00416 Ribosomal protein S13/S18 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3311 Ribosomal protein S18 Cluster-8309.40581 BF_2 6897.78 121.50 2662 478250527 ENN71022.1 1626 4.9e-178 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] 194745413 XM_001955147.1 241 1.28679e-120 Drosophila ananassae GF18634 (Dana\GF18634), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1361 1.1e-148 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40582 BF_2 660.79 64.91 713 478250527 ENN71022.1 379 5.2e-34 hypothetical protein YQE_12421, partial [Dendroctonus ponderosae]>gi|546678988|gb|ERL89521.1| hypothetical protein D910_06887 [Dendroctonus ponderosae] -- -- -- -- -- K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 Q4R6M5 254 6.7e-21 Probable ATP-dependent RNA helicase DDX5 OS=Macaca fascicularis GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.40583 BF_2 3355.20 31.28 4774 546672885 ERL84608.1 3589 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1470 4.5e-161 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107//PF08545//PF00108 Zinc-binding dehydrogenase//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0055114//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//oxidation-reduction process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.40584 BF_2 11768.74 371.60 1612 332376114 AEE63197.1 1491 1.3e-162 unknown [Dendroctonus ponderosae] 641676797 XM_008189320.1 35 2.52726e-06 PREDICTED: Acyrthosiphon pisum PDZ and LIM domain protein Zasp (LOC100162539), transcript variant X5, mRNA -- -- -- -- A1ZA47 900 1.9e-95 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF00595//PF00412//PF13180//PF02843 PDZ domain (Also known as DHR or GLGF)//LIM domain//PDZ domain//Phosphoribosylglycinamide synthetase, C domain GO:0006144//GO:0009113 purine nucleobase metabolic process//purine nucleobase biosynthetic process GO:0005515//GO:0008270//GO:0004637 protein binding//zinc ion binding//phosphoribosylamine-glycine ligase activity -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.40585 BF_2 12.11 1.80 569 270007560 EFA04008.1 507 6.0e-49 hypothetical protein TcasGA2_TC014157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 278 8.8e-24 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.40586 BF_2 236.21 3.98 2770 91083989 XP_975221.1 158 8.6e-08 PREDICTED: CKLF-like MARVEL transmembrane domain-containing protein 8 [Tribolium castaneum]>gi|270007988|gb|EFA04436.1| hypothetical protein TcasGA2_TC014737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.40588 BF_2 589.03 4.73 5502 642931601 XP_008196651.1 4418 0.0e+00 PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum]>gi|642931603|ref|XP_008196652.1| PREDICTED: protein argonaute-2 isoform X1 [Tribolium castaneum] 723941700 KF986386.1 853 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3318 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02170//PF02171//PF04810 PAZ domain//Piwi domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0003676//GO:0008270//GO:0005515 nucleic acid binding//zinc ion binding//protein binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.4059 BF_2 1.00 0.90 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.40591 BF_2 2024.48 14.37 6180 478260998 ENN80588.1 6814 0.0e+00 hypothetical protein YQE_02993, partial [Dendroctonus ponderosae] 884965815 XM_010892944.2 162 2.47869e-76 PREDICTED: Esox lucius HECT domain containing E3 ubiquitin protein ligase 1 (hectd1), transcript variant X6, mRNA K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 4691 0.0e+00 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF06701//PF13606//PF00023 Mib_herc2//Ankyrin repeat//Ankyrin repeat GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515 ubiquitin-protein transferase activity//metal ion binding//protein binding -- -- KOG4276 Predicted hormone receptor interactor Cluster-8309.40593 BF_2 15.60 0.77 1135 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40594 BF_2 440.90 3.08 6270 642928815 XP_967995.2 1339 2.2e-144 PREDICTED: F-box only protein 33 [Tribolium castaneum] -- -- -- -- -- K10310 FBXO33 F-box protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K10310 Q7Z6M2 167 7.2e-10 F-box only protein 33 OS=Homo sapiens GN=FBXO33 PE=1 SV=1 PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.40595 BF_2 71.83 0.59 5396 91091818 XP_966528.1 972 6.8e-102 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AS29 785 1.4e-81 Glutamate receptor ionotropic, kainate 3 OS=Mus musculus GN=Grik3 PE=2 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.40596 BF_2 498.19 5.15 4330 189235866 XP_969616.2 4859 0.0e+00 PREDICTED: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [Tribolium castaneum]>gi|270004535|gb|EFA00983.1| hypothetical protein TcasGA2_TC003896 [Tribolium castaneum] 242012722 XM_002427032.1 602 0 Pediculus humanus corporis splicing factor ATP-dependent RNA helicase prp16, putative, mRNA K12815 DHX38, PRP16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 http://www.genome.jp/dbget-bin/www_bget?ko:K12815 Q92620 3643 0.0e+00 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Homo sapiens GN=DHX38 PE=1 SV=2 PF04408//PF02407//PF00437//PF00448//PF00005//PF01637//PF02562//PF00270//PF07652//PF00931 Helicase associated domain (HA2)//Putative viral replication protein//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//ABC transporter//Archaeal ATPase//PhoH-like protein//DEAD/DEAH box helicase//Flavivirus DEAD domain//NB-ARC domain GO:0006810//GO:0006614//GO:0019079//GO:0006260//GO:0018142//GO:0006144//GO:0006308 transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication//DNA replication//protein-DNA covalent cross-linking//purine nucleobase metabolic process//DNA catabolic process GO:0005524//GO:0016779//GO:0016887//GO:0008026//GO:0043531//GO:0016888//GO:0004386//GO:0005525//GO:0042624//GO:0003676 ATP binding//nucleotidyltransferase activity//ATPase activity//ATP-dependent helicase activity//ADP binding//endodeoxyribonuclease activity, producing 5'-phosphomonoesters//helicase activity//GTP binding//ATPase activity, uncoupled//nucleic acid binding -- -- KOG0924 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.40597 BF_2 295.30 4.40 3093 642939832 XP_008190719.1 946 4.1e-99 PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum]>gi|642939834|ref|XP_008190783.1| PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYP4 306 2.7e-26 Zinc finger C2HC domain-containing protein 1C OS=Rattus norvegicus GN=Zc2hc1c PE=2 SV=1 PF03884//PF16622//PF05191//PF00096//PF13465//PF02313//PF01155 Domain of unknown function (DUF329)//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Zinc-finger double domain//Fumarate reductase subunit D//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0046034//GO:0006144//GO:0006464//GO:0006106 ATP metabolic process//purine nucleobase metabolic process//cellular protein modification process//fumarate metabolic process GO:0016151//GO:0004017//GO:0046872//GO:0008270 nickel cation binding//adenylate kinase activity//metal ion binding//zinc ion binding GO:0016020 membrane KOG3940 Uncharacterized conserved protein Cluster-8309.40598 BF_2 10657.40 258.62 2011 91077452 XP_967401.1 1566 3.4e-171 PREDICTED: D-beta-hydroxybutyrate dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270001620|gb|EEZ98067.1| hypothetical protein TcasGA2_TC000474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02338 463 1.1e-44 D-beta-hydroxybutyrate dehydrogenase, mitochondrial OS=Homo sapiens GN=BDH1 PE=1 SV=3 PF01370//PF13676//PF00106 NAD dependent epimerase/dehydratase family//TIR domain//short chain dehydrogenase GO:0055114//GO:0007165//GO:0008152 oxidation-reduction process//signal transduction//metabolic process GO:0000166//GO:0003824//GO:0050662//GO:0016491//GO:0005515 nucleotide binding//catalytic activity//coenzyme binding//oxidoreductase activity//protein binding -- -- KOG1610 Corticosteroid 11-beta-dehydrogenase and related short chain-type dehydrogenases Cluster-8309.40599 BF_2 206.03 4.65 2141 546679409 ERL89880.1 1808 3.1e-199 hypothetical protein D910_07239 [Dendroctonus ponderosae] -- -- -- -- -- K01587 PAICS phosphoribosylaminoimidazole carboxylase / phosphoribosylaminoimidazole-succinocarboxamide synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01587 Q9I7S8 1473 9.0e-162 Multifunctional protein ADE2 OS=Drosophila melanogaster GN=ade5 PE=2 SV=2 PF00763//PF00731 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//AIR carboxylase GO:0009396//GO:0046487//GO:0055114//GO:0006189 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//oxidation-reduction process//'de novo' IMP biosynthetic process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG2835 Phosphoribosylamidoimidazole-succinocarboxamide synthase Cluster-8309.40600 BF_2 69.98 9.86 584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40601 BF_2 12.27 0.44 1466 91085847 XP_974980.1 899 5.4e-94 PREDICTED: LIM and SH3 domain protein F42H10.3 [Tribolium castaneum]>gi|270010142|gb|EFA06590.1| hypothetical protein TcasGA2_TC009504 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7C3 622 2.9e-63 LIM and SH3 domain protein Lasp OS=Drosophila melanogaster GN=Lasp PE=1 SV=2 PF00412 LIM domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1702 Nebulin repeat protein Cluster-8309.40603 BF_2 1366.77 7.11 8328 270015064 EFA11512.1 6503 0.0e+00 hypothetical protein TcasGA2_TC014226 [Tribolium castaneum] 665815330 XM_008558095.1 187 4.23465e-90 PREDICTED: Microplitis demolitor kinesin-like protein KIF13A (LOC103577457), transcript variant X3, mRNA K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 Q9H1H9 3358 0.0e+00 Kinesin-like protein KIF13A OS=Homo sapiens GN=KIF13A PE=1 SV=2 PF01496//PF00498//PF00225 V-type ATPase 116kDa subunit family//FHA domain//Kinesin motor domain GO:0007018//GO:0015991//GO:0007017//GO:0015992 microtubule-based movement//ATP hydrolysis coupled proton transport//microtubule-based process//proton transport GO:0005524//GO:0003777//GO:0005515//GO:0015078//GO:0008017 ATP binding//microtubule motor activity//protein binding//hydrogen ion transmembrane transporter activity//microtubule binding GO:0005874//GO:0045298//GO:0033179 microtubule//tubulin complex//proton-transporting V-type ATPase, V0 domain KOG0241 Kinesin-like protein Cluster-8309.40604 BF_2 788.00 17.27 2196 268607717 NP_001161316.1 503 6.7e-48 cuticular protein precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.40605 BF_2 460.98 1.80 10989 270015064 EFA11512.1 6011 0.0e+00 hypothetical protein TcasGA2_TC014226 [Tribolium castaneum] 642910931 XM_008195249.1 802 0 PREDICTED: Tribolium castaneum kinesin 3A (LOC661047), transcript variant X3, mRNA K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 Q9H1H9 3867 0.0e+00 Kinesin-like protein KIF13A OS=Homo sapiens GN=KIF13A PE=1 SV=2 PF01496//PF00225//PF01499//PF00498 V-type ATPase 116kDa subunit family//Kinesin motor domain//Herpesvirus UL25 family//FHA domain GO:0015992//GO:0007017//GO:0015991//GO:0019072//GO:0007018 proton transport//microtubule-based process//ATP hydrolysis coupled proton transport//viral genome packaging//microtubule-based movement GO:0008017//GO:0015078//GO:0003777//GO:0005515//GO:0005524 microtubule binding//hydrogen ion transmembrane transporter activity//microtubule motor activity//protein binding//ATP binding GO:0033179//GO:0045298//GO:0005874//GO:0042025 proton-transporting V-type ATPase, V0 domain//tubulin complex//microtubule//host cell nucleus KOG0241 Kinesin-like protein Cluster-8309.40610 BF_2 24.24 1.98 800 478249917 ENN70424.1 213 1.0e-14 hypothetical protein YQE_12929, partial [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 176 8.3e-12 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613 Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.40611 BF_2 118.85 1.38 3900 642936487 XP_008198457.1 2240 4.6e-249 PREDICTED: glutamate receptor ionotropic, kainate 3-like isoform X1 [Tribolium castaneum]>gi|270014114|gb|EFA10562.1| hypothetical protein TcasGA2_TC012818 [Tribolium castaneum] 462298669 APGK01051593.1 37 4.78548e-07 Dendroctonus ponderosae Seq01051603, whole genome shotgun sequence K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 1246 3.4e-135 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF00352//PF00060//PF10613//PF01699//PF05699 Transcription factor TFIID (or TATA-binding protein, TBP)//Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//Sodium/calcium exchanger protein//hAT family C-terminal dimerisation region GO:0007268//GO:0055085//GO:0007165//GO:0006811//GO:0006352 synaptic transmission//transmembrane transport//signal transduction//ion transport//DNA-templated transcription, initiation GO:0004970//GO:0005234//GO:0046983//GO:0003677//GO:0005216 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity//protein dimerization activity//DNA binding//ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.40612 BF_2 448.31 5.35 3793 642912192 XP_008200846.1 754 9.1e-77 PREDICTED: transmembrane protein 127-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q504G0 216 9.1e-16 Transmembrane protein 127 OS=Danio rerio GN=tmem127 PE=2 SV=1 PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.40613 BF_2 36.97 0.54 3127 642933047 XP_971594.2 1327 2.7e-143 PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum]>gi|642933049|ref|XP_008197242.1| PREDICTED: acetyl-coenzyme A transporter 1 [Tribolium castaneum] -- -- -- -- -- K03372 ACATN, SLC33A1 MFS transporter, PAT family, solute carrier family 33 (acetyl-CoA transportor), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03372 Q6AYY8 933 5.4e-99 Acetyl-coenzyme A transporter 1 OS=Rattus norvegicus GN=Slc33a1 PE=2 SV=1 PF05656//PF07690//PF13000 Protein of unknown function (DUF805)//Major Facilitator Superfamily//Acetyl-coenzyme A transporter 1 GO:0015876//GO:0055085 acetyl-CoA transport//transmembrane transport GO:0008521 acetyl-CoA transporter activity GO:0016021 integral component of membrane KOG3574 Acetyl-CoA transporter Cluster-8309.40619 BF_2 87.08 1.08 3659 649572255 NP_001280540.1 1336 2.9e-144 FMRFamide receptor [Tribolium castaneum]>gi|91078222|ref|XP_969392.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915085|ref|XP_008190406.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915087|ref|XP_008190407.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|270002872|gb|EEZ99319.1| hypothetical protein TcasGA2_TC001381 [Tribolium castaneum]>gi|485836781|tpg|DAA64478.1| TPA_inf: FMRFamide-like G protein-coupled receptor [Tribolium castaneum] 158301538 XM_321207.2 76 9.3751e-29 Anopheles gambiae str. PEST AGAP001862-PA (GPRNNA1) mRNA, complete cds -- -- -- -- Q9VZW5 891 4.7e-94 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.40620 BF_2 12.00 0.39 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277//PF06632 Oxaloacetate decarboxylase, gamma chain//DNA double-strand break repair and V(D)J recombination protein XRCC4 GO:0006525//GO:0006560//GO:0006310//GO:0006814//GO:0071436//GO:0006090//GO:0006302 arginine metabolic process//proline metabolic process//DNA recombination//sodium ion transport//sodium ion export//pyruvate metabolic process//double-strand break repair GO:0003677//GO:0008948//GO:0015081 DNA binding//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane -- -- Cluster-8309.40621 BF_2 1300.79 4.14 13439 478257788 ENN77931.1 3951 0.0e+00 hypothetical protein YQE_05608, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 435 1.3e-40 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF10034//PF13606//PF00023 Q-cell neuroblast polarisation//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.40624 BF_2 31.48 0.33 4243 189234829 XP_001811696.1 1732 4.0e-190 PREDICTED: protein fem-1 homolog CG6966 isoform X1 [Tribolium castaneum]>gi|270001481|gb|EEZ97928.1| hypothetical protein TcasGA2_TC000315 [Tribolium castaneum] 831477033 XM_012857159.1 113 2.94234e-49 PREDICTED: Fundulus heteroclitus fem-1 homolog c (C. elegans) (fem1c), mRNA -- -- -- -- Q9VFD5 890 7.1e-94 Protein fem-1 homolog CG6966 OS=Drosophila melanogaster GN=CG6966 PE=2 SV=2 PF00023//PF13374//PF13606 Ankyrin repeat//Tetratricopeptide repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.40626 BF_2 1136.81 7.23 6863 642921007 XP_008192651.1 2135 1.2e-236 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 2.79219e-66 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7RTS6 149 9.7e-08 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF01499 Herpesvirus UL25 family GO:0019072 viral genome packaging -- -- GO:0042025 host cell nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.40627 BF_2 286.00 2.00 6262 478255994 ENN76193.1 2025 6.3e-224 hypothetical protein YQE_07161, partial [Dendroctonus ponderosae] -- -- -- -- -- K11423 SETD2, SET2 histone-lysine N-methyltransferase SETD2 http://www.genome.jp/dbget-bin/www_bget?ko:K11423 Q9VYD1 849 6.0e-89 Probable histone-lysine N-methyltransferase CG1716 OS=Drosophila melanogaster GN=Set2 PE=1 SV=2 PF15761//PF00856//PF08236//PF00397 Immortalisation up-regulated protein//SET domain//SRI (Set2 Rpb1 interacting) domain//WW domain GO:0006355//GO:0006479//GO:0006554//GO:0034968 regulation of transcription, DNA-templated//protein methylation//lysine catabolic process//histone lysine methylation GO:0018024//GO:0005515 histone-lysine N-methyltransferase activity//protein binding GO:0005694//GO:0005634 chromosome//nucleus KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.40628 BF_2 60.00 17.87 427 91084765 XP_972022.1 379 3.1e-34 PREDICTED: cytochrome c oxidase assembly protein COX16 homolog, mitochondrial [Tribolium castaneum]>gi|270008948|gb|EFA05396.1| hypothetical protein TcasGA2_TC015568 [Tribolium castaneum] -- -- -- -- -- K18182 COX16 cytochrome c oxidase assembly protein subunit 16 http://www.genome.jp/dbget-bin/www_bget?ko:K18182 Q9P0S2 206 1.5e-15 Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial OS=Homo sapiens GN=COX16 PE=3 SV=1 PF14138//PF00322 Cytochrome c oxidase assembly protein COX16//Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0031966//GO:0005576 mitochondrial membrane//extracellular region -- -- Cluster-8309.40629 BF_2 22.28 1.19 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40630 BF_2 288.76 5.35 2544 728418014 AIY68354.1 1400 7.6e-152 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 583 1.7e-58 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF02950//PF07859//PF02230//PF00326 Conotoxin//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family GO:0009405//GO:0008152//GO:0006810//GO:0006508 pathogenesis//metabolic process//transport//proteolysis GO:0016787//GO:0008200//GO:0008236 hydrolase activity//ion channel inhibitor activity//serine-type peptidase activity GO:0005576 extracellular region -- -- Cluster-8309.40632 BF_2 81.99 0.55 6548 642914795 XP_008190356.1 5175 0.0e+00 PREDICTED: fatty acid synthase [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 1105 1.3e-118 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF00975//PF00107 Thioesterase domain//Zinc-binding dehydrogenase GO:0009058//GO:0055114 biosynthetic process//oxidation-reduction process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.40633 BF_2 603.78 5.48 4898 91084547 XP_973113.1 3577 0.0e+00 PREDICTED: protein unc-45 homolog B [Tribolium castaneum]>gi|270009248|gb|EFA05696.1| translocase of outer membrane 34 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F64 1674 1.0e-184 Protein unc-45 homolog B OS=Xenopus laevis GN=unc45b PE=2 SV=1 PF13371//PF00515//PF13374//PF13176//PF03152//PF08718//PF13414//PF13181//PF00839//PF00514 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Ubiquitin fusion degradation protein UFD1//Glycolipid transfer protein (GLTP)//TPR repeat//Tetratricopeptide repeat//Cysteine rich repeat//Armadillo/beta-catenin-like repeat GO:0006511//GO:0046836 ubiquitin-dependent protein catabolic process//glycolipid transport GO:0017089//GO:0051861//GO:0005515 glycolipid transporter activity//glycolipid binding//protein binding GO:0016020//GO:0005737 membrane//cytoplasm KOG1816 Ubiquitin fusion-degradation protein Cluster-8309.40635 BF_2 28.94 0.95 1556 282158091 NP_001164089.1 698 1.2e-70 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P14324 435 1.5e-41 Farnesyl pyrophosphate synthase OS=Homo sapiens GN=FDPS PE=1 SV=4 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.40637 BF_2 396.81 23.65 989 449139004 AGE89831.1 882 3.4e-92 isoprenyl diphosphate synthase [Phaedon cochleariae] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P08836 490 4.0e-48 Farnesyl pyrophosphate synthase OS=Gallus gallus GN=FDPS PE=1 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.40641 BF_2 560.38 3.62 6770 642934517 XP_008197696.1 5483 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein Mi-2 homolog isoform X1 [Tribolium castaneum]>gi|270013510|gb|EFA09958.1| hypothetical protein TcasGA2_TC012115 [Tribolium castaneum] 815926192 XM_012392264.1 601 0 PREDICTED: Bombus impatiens chromodomain-helicase-DNA-binding protein Mi-2 homolog (LOC100740721), transcript variant X10, mRNA K11643 CHD4, MI2B chromodomain-helicase-DNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11643 O97159 4696 0.0e+00 Chromodomain-helicase-DNA-binding protein Mi-2 homolog OS=Drosophila melanogaster GN=Mi-2 PE=1 SV=2 PF00628//PF00001//PF06357//PF00130//PF08073//PF00641//PF04851//PF00176//PF00270//PF08074 PHD-finger//7 transmembrane receptor (rhodopsin family)//Omega-atracotoxin//Phorbol esters/diacylglycerol binding domain (C1 domain)//CHDNT (NUC034) domain//Zn-finger in Ran binding protein and others//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//DEAD/DEAH box helicase//CHDCT2 (NUC038) domain GO:0006810//GO:0006952//GO:0009405//GO:0035556//GO:0006355//GO:0007186 transport//defense response//pathogenesis//intracellular signal transduction//regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway GO:0016787//GO:0005524//GO:0019855//GO:0016818//GO:0008270//GO:0005515//GO:0004930//GO:0003677//GO:0004386//GO:0003676//GO:0043169 hydrolase activity//ATP binding//calcium channel inhibitor activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//protein binding//G-protein coupled receptor activity//DNA binding//helicase activity//nucleic acid binding//cation binding GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG0383 Predicted helicase Cluster-8309.40642 BF_2 59.81 0.49 5401 642925447 XP_008194558.1 454 8.0e-42 PREDICTED: cellular FABP-like protein isoform X2 [Tribolium castaneum] 797056877 HG313989.1 36 2.38976e-06 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 11 K08756 FABP7 fatty acid-binding protein 7, brain http://www.genome.jp/dbget-bin/www_bget?ko:K08756 A6YLM6 230 3.1e-17 Fatty acid-binding protein, adipocyte OS=Cervus elaphus GN=FABP4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.40644 BF_2 134.62 7.44 1044 270009349 EFA05797.1 610 1.3e-60 hypothetical protein TcasGA2_TC030588 [Tribolium castaneum] -- -- -- -- -- K14156 CHK choline/ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14156 Q9Y259 319 2.9e-28 Choline/ethanolamine kinase OS=Homo sapiens GN=CHKB PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2686 Choline kinase Cluster-8309.40646 BF_2 624.65 7.26 3887 641664379 XP_001943157.3 2635 7.2e-295 PREDICTED: FERM, RhoGEF and pleckstrin domain-containing protein 2 [Acyrthosiphon pisum] 751460266 XM_011186586.1 188 5.47046e-91 PREDICTED: Bactrocera cucurbitae FERM, RhoGEF and pleckstrin domain-containing protein 2-like (LOC105213626), transcript variant X3, mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 8.5e-118 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF08172//PF00621 CASP C terminal//RhoGEF domain GO:0043087//GO:0035023//GO:0006891 regulation of GTPase activity//regulation of Rho protein signal transduction//intra-Golgi vesicle-mediated transport GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane KOG3531 Rho guanine nucleotide exchange factor CDEP Cluster-8309.40647 BF_2 123.19 1.59 3521 270007176 EFA03624.1 2174 1.9e-241 hypothetical protein TcasGA2_TC013717 [Tribolium castaneum] 642922446 XM_008194952.1 115 1.88421e-50 PREDICTED: Tribolium castaneum titin-like (LOC655359), mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 7.7e-118 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF08172//PF00621 CASP C terminal//RhoGEF domain GO:0043087//GO:0006891//GO:0035023 regulation of GTPase activity//intra-Golgi vesicle-mediated transport//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane -- -- Cluster-8309.40648 BF_2 370.35 9.67 1889 91080555 XP_967130.1 722 2.3e-73 PREDICTED: clathrin light chain isoform X1 [Tribolium castaneum] -- -- -- -- -- K04644 CLTA, LCA clathrin light chain A http://www.genome.jp/dbget-bin/www_bget?ko:K04644 Q9VWA1 368 1.1e-33 Clathrin light chain OS=Drosophila melanogaster GN=Clc PE=2 SV=1 PF13855//PF01086 Leucine rich repeat//Clathrin light chain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.40650 BF_2 92.45 0.56 7147 642920624 XP_008192494.1 1089 2.5e-115 PREDICTED: glycosyltransferase-like protein LARGE2 [Tribolium castaneum] -- -- -- -- -- K09668 LARGE glycosyltransferase-like protein LARGE http://www.genome.jp/dbget-bin/www_bget?ko:K09668 Q66PG3 757 3.2e-78 Glycosyltransferase-like protein LARGE1 OS=Gallus gallus GN=LARGE PE=2 SV=1 PF01545//PF09329//PF01501//PF00957//PF00711 Cation efflux family//Primase zinc finger//Glycosyl transferase family 8//Synaptobrevin//Beta defensin GO:0006260//GO:0006812//GO:0055085//GO:0016192//GO:0006952 DNA replication//cation transport//transmembrane transport//vesicle-mediated transport//defense response GO:0008324//GO:0016757 cation transmembrane transporter activity//transferase activity, transferring glycosyl groups GO:0005576//GO:0005634//GO:0016021 extracellular region//nucleus//integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.40653 BF_2 880.73 5.37 7153 91088357 XP_971705.1 1276 5.1e-137 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|270011777|gb|EFA08225.1| hypothetical protein TcasGA2_TC005852 [Tribolium castaneum] -- -- -- -- -- K17232 DUOXA2 dual oxidase maturation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17232 Q6DDK3 372 1.4e-33 Dual oxidase maturation factor 1 OS=Xenopus laevis GN=duoxa1 PE=2 SV=1 PF00096//PF01283//PF04062//PF17123//PF10204//PF00651 Zinc finger, C2H2 type//Ribosomal protein S26e//ARP2/3 complex ARPC3 (21 kDa) subunit//RING-like zinc finger//Dual oxidase maturation factor//BTB/POZ domain GO:0030833//GO:0034314//GO:0015031//GO:0042254//GO:0006412 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation//protein transport//ribosome biogenesis//translation GO:0003735//GO:0008270//GO:0005515//GO:0046872 structural constituent of ribosome//zinc ion binding//protein binding//metal ion binding GO:0016021//GO:0005622//GO:0005885//GO:0005840//GO:0005856//GO:0005789//GO:0044425 integral component of membrane//intracellular//Arp2/3 protein complex//ribosome//cytoskeleton//endoplasmic reticulum membrane//membrane part -- -- Cluster-8309.40654 BF_2 118.32 0.76 6834 91085003 XP_973266.1 2982 0.0e+00 PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|642926204|ref|XP_008194828.1| PREDICTED: glycogen [starch] synthase [Tribolium castaneum]>gi|270009020|gb|EFA05468.1| hypothetical protein TcasGA2_TC015651 [Tribolium castaneum] 194742159 XM_001953538.1 227 2.01674e-112 Drosophila ananassae GF17161 (Dana\GF17161), mRNA K00693 GYS glycogen(starch) synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00693 Q9VFC8 2563 1.2e-287 Glycogen [starch] synthase OS=Drosophila melanogaster GN=GlyS PE=1 SV=2 PF02535//PF00439//PF05693 ZIP Zinc transporter//Bromodomain//Glycogen synthase GO:0005978//GO:0005982//GO:0030001//GO:0055085//GO:0005985 glycogen biosynthetic process//starch metabolic process//metal ion transport//transmembrane transport//sucrose metabolic process GO:0046873//GO:0004373//GO:0005515 metal ion transmembrane transporter activity//glycogen (starch) synthase activity//protein binding GO:0016020 membrane KOG3742 Glycogen synthase Cluster-8309.40655 BF_2 170.00 13.15 828 91082307 XP_974197.1 721 1.3e-73 PREDICTED: inosine triphosphate pyrophosphatase [Tribolium castaneum]>gi|270007471|gb|EFA03919.1| hypothetical protein TcasGA2_TC014054 [Tribolium castaneum] -- -- -- -- -- K01519 ITPA inosine triphosphate pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01519 Q7Q4F5 688 3.7e-71 Inosine triphosphate pyrophosphatase OS=Anopheles gambiae GN=AGAP008374 PE=3 SV=2 PF01725 Ham1 family -- -- GO:0016787 hydrolase activity -- -- KOG3222 Inosine triphosphate pyrophosphatase Cluster-8309.40657 BF_2 4367.00 19.40 9706 817084369 XP_012264833.1 1743 4.9e-191 PREDICTED: cAMP-dependent protein kinase catalytic subunit [Athalia rosae] 462451100 APGK01007788.1 477 0 Dendroctonus ponderosae Seq01007796, whole genome shotgun sequence K04345 PKA protein kinase A http://www.genome.jp/dbget-bin/www_bget?ko:K04345 P12370 1693 1.3e-186 cAMP-dependent protein kinase catalytic subunit OS=Drosophila melanogaster GN=Pka-C1 PE=1 SV=3 PF00069//PF05933//PF07714 Protein kinase domain//Fungal ATP synthase protein 8 (A6L)//Protein tyrosine kinase GO:0015992//GO:0006468//GO:0015986 proton transport//protein phosphorylation//ATP synthesis coupled proton transport GO:0004672//GO:0005524//GO:0015078 protein kinase activity//ATP binding//hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.40658 BF_2 132.17 1.26 4666 642915296 XP_008190559.1 391 1.4e-34 PREDICTED: signal recognition particle 9 kDa protein [Tribolium castaneum]>gi|270004979|gb|EFA01427.1| hypothetical protein TcasGA2_TC030568 [Tribolium castaneum] -- -- -- -- -- K03109 SRP9 signal recognition particle subunit SRP9 http://www.genome.jp/dbget-bin/www_bget?ko:K03109 Q9VSC1 231 2.0e-17 Signal recognition particle 9 kDa protein OS=Drosophila melanogaster GN=Srp9 PE=3 SV=1 -- -- GO:0006614//GO:0045900 SRP-dependent cotranslational protein targeting to membrane//negative regulation of translational elongation GO:0008312 7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3465 Signal recognition particle, subunit Srp9 Cluster-8309.40660 BF_2 85.02 1.13 3424 642924809 XP_008194049.1 3098 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X1 [Tribolium castaneum] 195497284 XM_002095999.1 117 1.41604e-51 Drosophila yakuba GE25295 (Dyak\GE25295), partial mRNA -- -- -- -- Q5ZMS4 324 2.5e-28 Nuclear receptor coactivator 7 OS=Gallus gallus GN=NCOA7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.40664 BF_2 396.98 2.97 5881 642912571 XP_008200914.1 1898 3.1e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.06649e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.2e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF00617 RasGEF domain GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.40667 BF_2 43.80 0.42 4642 332376491 AEE63385.1 1362 3.5e-147 unknown [Dendroctonus ponderosae]>gi|546680485|gb|ERL90751.1| hypothetical protein D910_08098 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q16T79 1220 4.2e-132 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Aedes aegypti GN=AAEL010360 PE=3 SV=2 PF00437//PF02951//PF03082//PF01583//PF07728//PF08912//PF00931//PF08702//PF00005//PF03193//PF09177//PF07989//PF06414 Type II/IV secretion system protein//Prokaryotic glutathione synthetase, N-terminal domain//Male accessory gland secretory protein//Adenylylsulphate kinase//AAA domain (dynein-related subfamily)//Rho Binding//NB-ARC domain//Fibrinogen alpha/beta chain family//ABC transporter//Protein of unknown function, DUF258//Syntaxin 6, N-terminal//Centrosomin N-terminal motif 1//Zeta toxin GO:0006144//GO:0000103//GO:0048193//GO:0007618//GO:0030168//GO:0051258//GO:0006810//GO:0007165//GO:0006750 purine nucleobase metabolic process//sulfate assimilation//Golgi vesicle transport//mating//platelet activation//protein polymerization//transport//signal transduction//glutathione biosynthetic process GO:0043531//GO:0004020//GO:0017048//GO:0030674//GO:0005525//GO:0003924//GO:0005524//GO:0004363//GO:0016887//GO:0005102//GO:0016301 ADP binding//adenylylsulfate kinase activity//Rho GTPase binding//protein binding, bridging//GTP binding//GTPase activity//ATP binding//glutathione synthase activity//ATPase activity//receptor binding//kinase activity GO:0005576//GO:0016020//GO:0005815//GO:0005577 extracellular region//membrane//microtubule organizing center//fibrinogen complex KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.40669 BF_2 565.94 3.39 7271 91079915 XP_967163.1 3071 0.0e+00 PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|642918342|ref|XP_008196887.1| PREDICTED: cold shock domain-containing protein E1 [Tribolium castaneum]>gi|270003264|gb|EEZ99711.1| hypothetical protein TcasGA2_TC002472 [Tribolium castaneum] 642918340 XM_962070.3 658 0 PREDICTED: Tribolium castaneum cold shock domain-containing protein E1 (LOC655517), transcript variant X1, mRNA -- -- -- -- P18395 1330 1.2e-144 Cold shock domain-containing protein E1 OS=Rattus norvegicus GN=Csde1 PE=2 SV=1 PF00313//PF02099 'Cold-shock' DNA-binding domain//Josephin GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008242 DNA binding//omega peptidase activity -- -- KOG2935 Ataxin 3/Josephin Cluster-8309.40670 BF_2 17.00 1.38 803 291170320 ADD82416.1 198 5.7e-13 minus-C odorant binding protein 3 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40672 BF_2 396.00 40.62 695 758343053 AJO67868.1 391 2.1e-35 odorant binding protein 6 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.40673 BF_2 623.98 8.73 3277 91080113 XP_967415.1 1588 1.5e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit I [Tribolium castaneum]>gi|270003188|gb|EEZ99635.1| hypothetical protein TcasGA2_TC002391 [Tribolium castaneum] 642918634 XM_962322.2 236 9.55161e-118 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 3 subunit I (LOC655760), mRNA K03246 EIF3I translation initiation factor 3 subunit I http://www.genome.jp/dbget-bin/www_bget?ko:K03246 Q1HPW4 1315 2.9e-143 Eukaryotic translation initiation factor 3 subunit I OS=Bombyx mori PE=2 SV=1 PF00400//PF10505//PF10766//PF04053 WD domain, G-beta repeat//NMDA receptor-regulated gene protein 2 C-terminus//Multidrug efflux pump-associated protein AcrZ//Coatomer WD associated region GO:0015893//GO:0006886//GO:0016192//GO:0006855 drug transport//intracellular protein transport//vesicle-mediated transport//drug transmembrane transport GO:0015238//GO:0005515//GO:0005198 drug transmembrane transporter activity//protein binding//structural molecule activity GO:0030117//GO:0005886//GO:0008023 membrane coat//plasma membrane//transcription elongation factor complex KOG0643 Translation initiation factor 3, subunit i (eIF-3i)/TGF-beta receptor-interacting protein (TRIP-1) Cluster-8309.40675 BF_2 116.25 3.85 1549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40676 BF_2 810.50 23.78 1713 546685707 ERL95168.1 395 1.8e-35 hypothetical protein D910_12437 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VBV3 251 3.6e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40677 BF_2 289.96 1.19 10517 270006380 EFA02828.1 2538 3.4e-283 insulin-like growth factor receptor [Tribolium castaneum]>gi|570932717|gb|AHF20215.1| insulin like receptor 2 [Tribolium castaneum] 471364329 XM_004372657.1 83 3.4822e-32 PREDICTED: Trichechus manatus latirostris insulin-like growth factor 1 receptor (LOC101355333), mRNA K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q60751 1871 3.1e-207 Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 PF00041//PF00909//PF00757//PF16656//PF08727//PF07714//PF00069 Fibronectin type III domain//Ammonium Transporter Family//Furin-like cysteine rich region//Purple acid Phosphatase, N-terminal domain//Poliovirus 3A protein like//Protein tyrosine kinase//Protein kinase domain GO:0006144//GO:0015696//GO:0007169//GO:0006771//GO:0006508//GO:0019497//GO:0006468 purine nucleobase metabolic process//ammonium transport//transmembrane receptor protein tyrosine kinase signaling pathway//riboflavin metabolic process//proteolysis//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0005515//GO:0046872//GO:0004672//GO:0017111//GO:0004714//GO:0004197//GO:0003968//GO:0008519//GO:0005524//GO:0003993 protein binding//metal ion binding//protein kinase activity//nucleoside-triphosphatase activity//transmembrane receptor protein tyrosine kinase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity//ammonium transmembrane transporter activity//ATP binding//acid phosphatase activity GO:0031379//GO:0016020 RNA-directed RNA polymerase complex//membrane KOG3796 Ammonium transporter RHBG Cluster-8309.40678 BF_2 435.00 46.09 682 642926703 XP_970920.2 317 7.7e-27 PREDICTED: uncharacterized protein LOC659528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76879 206 2.4e-15 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40682 BF_2 1137.62 14.11 3660 642931127 XP_008201673.1 3349 0.0e+00 PREDICTED: uncharacterized protein LOC655872 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40684 BF_2 53.68 0.59 4116 189236397 XP_971210.2 1202 1.1e-128 PREDICTED: ATP-binding cassette sub-family G member 1 isoform X2 [Tribolium castaneum]>gi|642919759|ref|XP_008192054.1| PREDICTED: ATP-binding cassette sub-family G member 1 isoform X2 [Tribolium castaneum]>gi|270005417|gb|EFA01865.1| hypothetical protein TcasGA2_TC007470 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 714 1.8e-73 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF00437//PF01061//PF13304//PF01926//PF01637//PF06414//PF00005//PF03193 Type II/IV secretion system protein//ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Archaeal ATPase//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0006200//GO:0006810 obsolete ATP catabolic process//transport GO:0016887//GO:0016301//GO:0005525//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.40688 BF_2 49.86 0.60 3763 91083631 XP_970382.1 2205 5.1e-245 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.49299e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 1600 3.0e-176 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF03188//PF02826//PF01752//PF00205//PF07074//PF00107//PF00005//PF02233 Eukaryotic cytochrome b561//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Collagenase//Thiamine pyrophosphate enzyme, central domain//Translocon-associated protein, gamma subunit (TRAP-gamma)//Zinc-binding dehydrogenase//ABC transporter//NAD(P) transhydrogenase beta subunit GO:0006508//GO:0055114//GO:0006769//GO:0015992//GO:0046497//GO:0006613 proteolysis//oxidation-reduction process//nicotinamide metabolic process//proton transport//nicotinate nucleotide metabolic process//cotranslational protein targeting to membrane GO:0030976//GO:0000287//GO:0051287//GO:0050661//GO:0004252//GO:0008270//GO:0016887//GO:0008750//GO:0005524 thiamine pyrophosphate binding//magnesium ion binding//NAD binding//NADP binding//serine-type endopeptidase activity//zinc ion binding//ATPase activity//NAD(P)+ transhydrogenase (AB-specific) activity//ATP binding GO:0005576//GO:0005784//GO:0030176//GO:0016021 extracellular region//Sec61 translocon complex//integral component of endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.40689 BF_2 1777.75 17.94 4432 91091360 XP_972551.1 1769 2.1e-194 PREDICTED: 26S protease regulatory subunit 8 [Tribolium castaneum] 242005916 XM_002423761.1 495 0 Pediculus humanus corporis 26S protease regulatory subunit, putative, mRNA K03066 PSMC5, RPT6 26S proteasome regulatory subunit T6 http://www.genome.jp/dbget-bin/www_bget?ko:K03066 O18413 1711 4.7e-189 26S protease regulatory subunit 8 OS=Drosophila melanogaster GN=Rpt6 PE=1 SV=2 PF00004//PF07724//PF07728//PF01695//PF06068//PF00158//PF01057//PF05496//PF00910//PF07726//PF02367//PF06414//PF02562 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//RNA helicase//ATPase family associated with various cellular activities (AAA)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//PhoH-like protein GO:0002949//GO:0006310//GO:0006355//GO:0019079//GO:0006281 tRNA threonylcarbamoyladenosine modification//DNA recombination//regulation of transcription, DNA-templated//viral genome replication//DNA repair GO:0009378//GO:0003724//GO:0003678//GO:0003723//GO:0016301//GO:0016887//GO:0005524//GO:0008134 four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding//kinase activity//ATPase activity//ATP binding//transcription factor binding GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG0728 26S proteasome regulatory complex, ATPase RPT6 Cluster-8309.40690 BF_2 80.09 0.56 6316 642936704 XP_008198546.1 2613 4.2e-292 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142542 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P07207 158 8.1e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF13895//PF02793//PF00008 Immunoglobulin domain//Hormone receptor domain//EGF-like domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016020 membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.40691 BF_2 67.45 0.74 4076 642914748 XP_008190336.1 5338 0.0e+00 PREDICTED: potassium channel subfamily T member 2 [Tribolium castaneum] 642914747 XM_008192114.1 1137 0 PREDICTED: Tribolium castaneum potassium channel subfamily T member 2 (LOC655919), mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q8QFV0 1603 1.4e-176 Potassium channel subfamily T member 1 OS=Gallus gallus GN=KCNT1 PE=2 SV=1 PF03493//PF00520 Calcium-activated BK potassium channel alpha subunit//Ion transport protein GO:0006813//GO:0006811//GO:0055085 potassium ion transport//ion transport//transmembrane transport GO:0015269//GO:0005216 calcium-activated potassium channel activity//ion channel activity GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.40692 BF_2 1271.67 41.05 1583 270297202 NP_001161902.1 1698 1.3e-186 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 1286 3.2e-140 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 PF02602 Uroporphyrinogen-III synthase HemD GO:0033014//GO:0006783//GO:0015994//GO:0008152 tetrapyrrole biosynthetic process//heme biosynthetic process//chlorophyll metabolic process//metabolic process GO:0004852//GO:0033961 uroporphyrinogen-III synthase activity//cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.40693 BF_2 33.77 1.01 1681 91094771 XP_967866.1 1686 3.4e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.3e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.40696 BF_2 742.84 3.94 8182 270016796 EFA13242.1 3554 0.0e+00 hypothetical protein TcasGA2_TC001512 [Tribolium castaneum] 642938255 XM_008199910.1 478 0 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X3, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O35598 1514 6.0e-166 Disintegrin and metalloproteinase domain-containing protein 10 OS=Mus musculus GN=Adam10 PE=1 SV=2 PF01421//PF11857//PF01562 Reprolysin (M12B) family zinc metalloprotease//Domain of unknown function (DUF3377)//Reprolysin family propeptide GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.40700 BF_2 533.23 2.71 8512 642910377 XP_971554.2 7752 0.0e+00 PREDICTED: uncharacterized protein LOC660207 isoform X3 [Tribolium castaneum] 194747504 XM_001956156.1 230 5.40484e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q9CPW0 626 5.9e-63 Contactin-associated protein-like 2 OS=Mus musculus GN=Cntnap2 PE=1 SV=2 PF00008//PF02432//PF10192//PF00014 EGF-like domain//Fimbrial, major and minor subunit//Rhodopsin-like GPCR transmembrane domain//Kunitz/Bovine pancreatic trypsin inhibitor domain GO:0019236//GO:0007186//GO:0007155 response to pheromone//G-protein coupled receptor signaling pathway//cell adhesion GO:0005515//GO:0004867 protein binding//serine-type endopeptidase inhibitor activity GO:0009289 pilus -- -- Cluster-8309.40701 BF_2 1284.18 69.78 1057 332374140 AEE62211.1 547 2.6e-53 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09521 NgoPII restriction endonuclease GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0003677//GO:0009036 DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.40702 BF_2 37.00 11.85 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40703 BF_2 2699.85 86.42 1594 478252421 ENN72845.1 860 2.0e-89 hypothetical protein YQE_10525, partial [Dendroctonus ponderosae]>gi|546677840|gb|ERL88597.1| hypothetical protein D910_05982 [Dendroctonus ponderosae] 209921946 EU797511.1 126 6.47207e-57 Pinctada fucata calcineurin B subunit mRNA, complete cds K06268 PPP3R, CNB serine/threonine-protein phosphatase 2B regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06268 Q24214 838 2.9e-88 Calcineurin subunit B type 2 OS=Drosophila melanogaster GN=CanB2 PE=1 SV=2 PF00036//PF13202//PF10229//PF13499//PF10591//PF13833//PF13405//PF12763 EF hand//EF hand//Uncharacterized conserved protein (DUF2246)//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Cytoskeletal-regulatory complex EF hand GO:0007165//GO:0009235 signal transduction//cobalamin metabolic process GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.40704 BF_2 253.92 2.06 5442 642927078 XP_008195127.1 1453 1.2e-157 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 1038 6.3e-111 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF00001//PF00002//PF02742 7 transmembrane receptor (rhodopsin family)//7 transmembrane receptor (Secretin family)//Iron dependent repressor, metal binding and dimerisation domain GO:0007186 G-protein coupled receptor signaling pathway GO:0046983//GO:0004930//GO:0046914 protein dimerization activity//G-protein coupled receptor activity//transition metal ion binding GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.40706 BF_2 423.86 2.05 8927 317039806 ADU87471.1 238 1.5e-16 glyceraldehyde 3-phosphate dehydrogenase [Munidopsis formosa] -- -- -- -- -- K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P56649 235 1.3e-17 Glyceraldehyde-3-phosphate dehydrogenase OS=Panulirus versicolor PE=1 SV=1 PF05456//PF02800//PF09771//PF02768//PF00044 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain//Transmembrane protein 188//DNA polymerase III beta subunit, C-terminal domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0035307//GO:0045947//GO:0006260//GO:0055114 positive regulation of protein dephosphorylation//negative regulation of translational initiation//DNA replication//oxidation-reduction process GO:0003677//GO:0003887//GO:0008408//GO:0016620//GO:0008190 DNA binding//DNA-directed DNA polymerase activity//3'-5' exonuclease activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//eukaryotic initiation factor 4E binding GO:0009360//GO:0042575//GO:0071595 DNA polymerase III complex//DNA polymerase complex//Nem1-Spo7 phosphatase complex KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.40707 BF_2 123.79 1.76 3236 642931611 XP_971230.2 3113 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Tribolium castaneum] 808137240 XR_001099267.1 138 2.83431e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 3.1e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.40708 BF_2 160.16 1.77 4077 642927357 XP_008195235.1 881 1.8e-91 PREDICTED: glutamate receptor ionotropic, kainate 2-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.40710 BF_2 666.92 5.24 5610 91082499 XP_972877.1 1298 1.1e-139 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q7ZU29 712 4.1e-73 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF04097//PF00637//PF06701//PF16276//PF02066//PF04121//PF00569 Nup93/Nic96//Region in Clathrin and VPS//Mib_herc2//Nucleophosmin C-terminal domain//Metallothionein family 11//Nuclear pore protein 84 / 107//Zinc finger, ZZ type GO:0006810//GO:0016192//GO:0016567//GO:0006886 transport//vesicle-mediated transport//protein ubiquitination//intracellular protein transport GO:0005507//GO:0004842//GO:0008270//GO:0003676//GO:0046872 copper ion binding//ubiquitin-protein transferase activity//zinc ion binding//nucleic acid binding//metal ion binding GO:0005643 nuclear pore -- -- Cluster-8309.40712 BF_2 26.77 0.49 2555 675380246 KFM73148.1 252 1.0e-18 hypothetical protein X975_19875, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40714 BF_2 418.56 1.60 11252 642938657 XP_008197674.1 3758 0.0e+00 PREDICTED: probable G-protein coupled receptor 125 [Tribolium castaneum] -- -- -- -- -- K09478 ACADSB short/branched chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09478 P45954 1254 1.2e-135 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1 PF02770//PF02771//PF00002//PF13855//PF00441//PF13895//PF02793//PF01825 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//7 transmembrane receptor (Secretin family)//Leucine rich repeat//Acyl-CoA dehydrogenase, C-terminal domain//Immunoglobulin domain//Hormone receptor domain//GPCR proteolysis site, GPS, motif GO:0008152//GO:0007186//GO:0006118//GO:0055114 metabolic process//G-protein coupled receptor signaling pathway//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0004930//GO:0005515//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//G-protein coupled receptor activity//protein binding//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0016020 integral component of membrane//membrane KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.40717 BF_2 205.62 3.86 2516 642920046 XP_975305.2 1015 3.3e-107 PREDICTED: kielin/chordin-like protein [Tribolium castaneum]>gi|270005328|gb|EFA01776.1| hypothetical protein TcasGA2_TC007377 [Tribolium castaneum] -- -- -- -- -- K11169 DHRS13 dehydrogenase/reductase SDR family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11169 Q17QU7 402 1.6e-37 Dehydrogenase/reductase SDR family member 13 OS=Bos taurus GN=DHRS13 PE=2 SV=1 PF01370//PF00106//PF01073 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008207//GO:0008209//GO:0006694//GO:0055114//GO:0008152//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//metabolic process//estrogen metabolic process GO:0050662//GO:0003824//GO:0003854//GO:0016616//GO:0016491 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- -- -- Cluster-8309.4072 BF_2 4.00 0.57 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40720 BF_2 1344.74 5.07 11392 642937913 XP_972695.3 1601 1.7e-174 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.6e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40721 BF_2 163.00 5.05 1637 321451287 EFX62988.1 233 1.0e-16 hypothetical protein DAPPUDRAFT_67487, partial [Daphnia pulex] 56968030 AY859576.1 713 0 Gaetice depressus 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- PF04726 Microvirus J protein -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.40722 BF_2 643.20 6.33 4535 546681613 ERL91677.1 2243 2.4e-249 hypothetical protein D910_09004 [Dendroctonus ponderosae] 241591921 XM_002403988.1 180 1.78954e-86 Ixodes scapularis 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase, putative, mRNA K19029 PFKFB2 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19029 Q91309 1435 4.9e-157 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Lithobates catesbeiana PE=2 SV=1 PF01591//PF06414 6-phosphofructo-2-kinase//Zeta toxin GO:0006013//GO:0006000 mannose metabolic process//fructose metabolic process GO:0003873//GO:0005524//GO:0016301 6-phosphofructo-2-kinase activity//ATP binding//kinase activity -- -- KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.40724 BF_2 804.00 5.43 6477 91089857 XP_971049.1 1232 5.8e-132 PREDICTED: mRNA-decapping enzyme 1B [Tribolium castaneum]>gi|270013572|gb|EFA10020.1| hypothetical protein TcasGA2_TC012192 [Tribolium castaneum] -- -- -- -- -- K12611 DCP1B mRNA-decapping enzyme 1B http://www.genome.jp/dbget-bin/www_bget?ko:K12611 Q8IZD4 345 1.7e-30 mRNA-decapping enzyme 1B OS=Homo sapiens GN=DCP1B PE=1 SV=2 PF01064//PF06058 Activin types I and II receptor domain//Dcp1-like decapping family GO:0016310//GO:0009069//GO:0007178//GO:0000290//GO:0043085 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway//deadenylation-dependent decapping of nuclear-transcribed mRNA//positive regulation of catalytic activity GO:0004675//GO:0008047 transmembrane receptor protein serine/threonine kinase activity//enzyme activator activity GO:0016020 membrane KOG2868 Decapping enzyme complex component DCP1 Cluster-8309.40726 BF_2 247.84 3.07 3660 66864094 BAD99298.1 1697 4.0e-186 ultraspiracle [Leptinotarsa decemlineata] 662618236 AB506667.1 134 5.37122e-61 Harmonia axyridis HaUSP-1 mRNA for ultraspiracle 1 isoform, complete cds K14030 NR2B4, usp nuclear receptor subfamily 2 group B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14030 Q5I7G2 1198 1.2e-129 Retinoic acid receptor RXR OS=Lymnaea stagnalis GN=RXR PE=1 SV=1 PF00105//PF00104//PF08997 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0006118//GO:0006355//GO:0043401//GO:0015992//GO:0006119 obsolete electron transport//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//proton transport//oxidative phosphorylation GO:0008270//GO:0009055//GO:0043565//GO:0003700//GO:0008121 zinc ion binding//electron carrier activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ubiquinol-cytochrome-c reductase activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.40727 BF_2 71.94 0.90 3642 66864094 BAD99298.1 1697 3.9e-186 ultraspiracle [Leptinotarsa decemlineata] 662618236 AB506667.1 134 5.34455e-61 Harmonia axyridis HaUSP-1 mRNA for ultraspiracle 1 isoform, complete cds K14030 NR2B4, usp nuclear receptor subfamily 2 group B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14030 Q5I7G2 1198 1.2e-129 Retinoic acid receptor RXR OS=Lymnaea stagnalis GN=RXR PE=1 SV=1 PF08997//PF00104//PF00105 Ubiquinol-cytochrome C reductase complex, 6.4kD protein//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006119//GO:0015992//GO:0006118//GO:0006355//GO:0043401 oxidative phosphorylation//proton transport//obsolete electron transport//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008121//GO:0003700//GO:0008270//GO:0009055//GO:0043565 ubiquinol-cytochrome-c reductase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//electron carrier activity//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40728 BF_2 2929.46 32.37 4073 642922011 XP_008192984.1 1727 1.5e-189 PREDICTED: ultraspiracle nuclear receptor isoform X1 [Tribolium castaneum] 662618236 AB506667.1 134 5.98334e-61 Harmonia axyridis HaUSP-1 mRNA for ultraspiracle 1 isoform, complete cds K14030 NR2B4, usp nuclear receptor subfamily 2 group B member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14030 Q5I7G2 1198 1.3e-129 Retinoic acid receptor RXR OS=Lymnaea stagnalis GN=RXR PE=1 SV=1 PF08997//PF00104//PF00105 Ubiquinol-cytochrome C reductase complex, 6.4kD protein//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0015992//GO:0006118//GO:0006355//GO:0043401//GO:0006119 proton transport//obsolete electron transport//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//oxidative phosphorylation GO:0003700//GO:0008270//GO:0009055//GO:0043565//GO:0008121 transcription factor activity, sequence-specific DNA binding//zinc ion binding//electron carrier activity//sequence-specific DNA binding//ubiquinol-cytochrome-c reductase activity GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.40729 BF_2 102.99 0.73 6192 642923453 XP_008193751.1 2402 1.2e-267 PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum]>gi|642923455|ref|XP_008193752.1| PREDICTED: sterol regulatory element-binding protein cleavage-activating protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JPH4 1046 8.5e-112 Sterol regulatory element-binding protein cleavage-activating protein OS=Xenopus laevis GN=scap PE=2 SV=1 PF07569//PF02460//PF00400 TUP1-like enhancer of split//Patched family//WD domain, G-beta repeat GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0008158//GO:0005515 hedgehog receptor activity//protein binding GO:0005634//GO:0016020 nucleus//membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.40731 BF_2 650.65 3.62 7798 642924396 XP_008194278.1 1678 1.3e-183 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] 706147644 XM_010207329.1 63 3.38337e-21 PREDICTED: Colius striatus family with sequence similarity 76, member B (FAM76B), partial mRNA -- -- -- -- Q5ZJ65 773 4.8e-80 Protein FAM76A OS=Gallus gallus GN=FAM76A PE=2 SV=1 PF07714//PF08656//PF00069//PF00541//PF00170//PF03852//PF01920//PF00227//PF03938//PF04728//PF04513//PF01025//PF00416 Protein tyrosine kinase//DASH complex subunit Dad3//Protein kinase domain//Adenoviral fibre protein (knob domain)//bZIP transcription factor//DNA mismatch endonuclease Vsr//Prefoldin subunit//Proteasome subunit//Outer membrane protein (OmpH-like)//Lipoprotein leucine-zipper//Baculovirus polyhedron envelope protein, PEP, C terminus//GrpE//Ribosomal protein S13/S18 GO:0042254//GO:0008608//GO:0006298//GO:0051603//GO:0006468//GO:0006355//GO:0006412//GO:0006457//GO:0019062 ribosome biogenesis//attachment of spindle microtubules to kinetochore//mismatch repair//proteolysis involved in cellular protein catabolic process//protein phosphorylation//regulation of transcription, DNA-templated//translation//protein folding//virion attachment to host cell GO:0005524//GO:0003700//GO:0051082//GO:0051087//GO:0003735//GO:0004519//GO:0004672//GO:0005198//GO:0000774//GO:0043565//GO:0003723//GO:0004298//GO:0042803 ATP binding//transcription factor activity, sequence-specific DNA binding//unfolded protein binding//chaperone binding//structural constituent of ribosome//endonuclease activity//protein kinase activity//structural molecule activity//adenyl-nucleotide exchange factor activity//sequence-specific DNA binding//RNA binding//threonine-type endopeptidase activity//protein homodimerization activity GO:0019028//GO:0016272//GO:0005667//GO:0072686//GO:0005839//GO:0005622//GO:0005840//GO:0042729//GO:0019031//GO:0019867 viral capsid//prefoldin complex//transcription factor complex//mitotic spindle//proteasome core complex//intracellular//ribosome//DASH complex//viral envelope//outer membrane KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.40733 BF_2 1187.07 8.50 6132 546670634 ERL83320.1 5497 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.49373e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 8.1e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF05191//PF00036//PF13405//PF06337//PF13499//PF00443//PF11421 Adenylate kinase, active site lid//EF hand//EF-hand domain//DUSP domain//EF-hand domain pair//Ubiquitin carboxyl-terminal hydrolase//ATP synthase F1 beta subunit GO:0046034//GO:0006144//GO:0006508//GO:0016579//GO:0006754 ATP metabolic process//purine nucleobase metabolic process//proteolysis//protein deubiquitination//ATP biosynthetic process GO:0004843//GO:0005524//GO:0036459//GO:0016887//GO:0005509//GO:0004017 ubiquitin-specific protease activity//ATP binding//ubiquitinyl hydrolase activity//ATPase activity//calcium ion binding//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.40735 BF_2 609.00 297.80 370 642924223 XP_008194205.1 353 2.8e-31 PREDICTED: endocuticle structural glycoprotein SgAbd-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7M4F3 246 2.9e-20 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.40736 BF_2 10295.56 61.21 7323 157136306 XP_001656823.1 2693 2.5e-301 AAEL003419-PA [Aedes aegypti]>gi|108881091|gb|EAT45316.1| AAEL003419-PA [Aedes aegypti] 332374193 BT127276.1 730 0 Dendroctonus ponderosae clone DPO011_E07 unknown mRNA -- -- -- -- P61023 569 2.1e-56 Calcineurin B homologous protein 1 OS=Rattus norvegicus GN=Chp1 PE=1 SV=2 PF12763//PF01522//PF13499//PF00963//PF13833//PF10591//PF13405//PF01708//PF13202//PF00036 Cytoskeletal-regulatory complex EF hand//Polysaccharide deacetylase//EF-hand domain pair//Cohesin domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Geminivirus putative movement protein//EF hand//EF hand GO:0007165//GO:0006030//GO:0000272//GO:0006807//GO:0005975//GO:0046740 signal transduction//chitin metabolic process//polysaccharide catabolic process//nitrogen compound metabolic process//carbohydrate metabolic process//transport of virus in host, cell to cell GO:0005515//GO:0005509//GO:0030246//GO:0016810//GO:0008061 protein binding//calcium ion binding//carbohydrate binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0016021//GO:0005576//GO:0005578 integral component of membrane//extracellular region//proteinaceous extracellular matrix KOG0034 Ca2+/calmodulin-dependent protein phosphatase (calcineurin subunit B), EF-Hand superfamily protein Cluster-8309.40738 BF_2 1166.62 12.10 4320 642922624 XP_008193254.1 3710 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] 642922625 XM_008195033.1 226 4.57316e-112 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40741 BF_2 190.79 5.97 1623 270011231 EFA07679.1 1076 1.8e-114 hypothetical protein TcasGA2_TC030712 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q80Z70 530 1.5e-52 Protein sel-1 homolog 1 OS=Rattus norvegicus GN=Sel1l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.40742 BF_2 110.68 4.08 1421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219//PF00093 Insulin-like growth factor binding protein//von Willebrand factor type C domain GO:0001558 regulation of cell growth GO:0005520//GO:0005515 insulin-like growth factor binding//protein binding GO:0005576//GO:0016942 extracellular region//insulin-like growth factor binding protein complex -- -- Cluster-8309.40743 BF_2 26.14 0.39 3089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40744 BF_2 113.20 0.98 5129 478258615 ENN78665.1 281 8.7e-22 hypothetical protein YQE_04837, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08720 Influenza C hemagglutinin stalk GO:0019064//GO:0007165 fusion of virus membrane with host plasma membrane//signal transduction GO:0046789 host cell surface receptor binding GO:0019031//GO:0009986 viral envelope//cell surface -- -- Cluster-8309.40745 BF_2 4.92 0.36 858 512891724 XP_004922754.1 331 2.3e-28 PREDICTED: phosphatidylethanolamine-binding protein homolog F40A3.3-like [Bombyx mori]>gi|512891728|ref|XP_004922755.1| PREDICTED: phosphatidylethanolamine-binding protein homolog F40A3.3-like [Bombyx mori] -- -- -- -- -- -- -- -- -- O16264 265 4.3e-22 Phosphatidylethanolamine-binding protein homolog F40A3.3 OS=Caenorhabditis elegans GN=F40A3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.40750 BF_2 3314.48 56.16 2756 665810054 XP_008553427.1 1656 1.7e-181 PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|665810056|ref|XP_008553428.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|751201535|ref|XP_011167836.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Solenopsis invicta]>gi|780681748|ref|XP_011697692.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Wasmannia auropunctata]>gi|795064613|ref|XP_011874023.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Vollenhovia emeryi]>gi|826425920|ref|XP_012527326.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Monomorium pharaonis] 642933469 XM_968453.3 436 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (LOC662352), mRNA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 P62716 1626 2.1e-179 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb PE=2 SV=1 PF02135//PF00149 TAZ zinc finger//Calcineurin-like phosphoesterase GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0003712//GO:0008270//GO:0004402//GO:0016787 transcription cofactor activity//zinc ion binding//histone acetyltransferase activity//hydrolase activity GO:0000123//GO:0005667//GO:0005634 histone acetyltransferase complex//transcription factor complex//nucleus KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-8309.40753 BF_2 1575.67 20.18 3554 478252006 ENN72441.1 2821 0.0e+00 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1423 9.4e-156 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF05173//PF01433 Dihydrodipicolinate reductase, C-terminus//Peptidase family M1 GO:0009089//GO:0055114//GO:0009085 lysine biosynthetic process via diaminopimelate//oxidation-reduction process//lysine biosynthetic process GO:0008270//GO:0008839//GO:0008237 zinc ion binding//4-hydroxy-tetrahydrodipicolinate reductase//metallopeptidase activity -- -- -- -- Cluster-8309.40754 BF_2 37.35 1.02 1822 270008882 EFA05330.1 382 6.0e-34 hypothetical protein TcasGA2_TC015494 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01842 134 1.4e-06 Ets DNA-binding protein pokkuri OS=Drosophila melanogaster GN=aop PE=1 SV=2 PF02198 Sterile alpha motif (SAM)/Pointed domain -- -- GO:0043565 sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.40757 BF_2 418.00 9.24 2180 546675819 ERL86931.1 746 4.4e-76 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 577 7.2e-58 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.40758 BF_2 192.91 2.48 3535 646712387 KDR17169.1 1960 1.2e-216 Extracellular sulfatase SULF-1-like protein, partial [Zootermopsis nevadensis] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 1747 2.5e-193 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- KOG3731 Sulfatases Cluster-8309.4076 BF_2 1.01 0.33 416 321476104 EFX87065.1 323 9.5e-28 hypothetical protein DAPPUDRAFT_307141 [Daphnia pulex] -- -- -- -- -- K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 295 6.9e-26 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF04557 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 GO:0006425 glutaminyl-tRNA aminoacylation GO:0000166//GO:0004819//GO:0005524 nucleotide binding//glutamine-tRNA ligase activity//ATP binding GO:0005737 cytoplasm KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.40761 BF_2 287.59 1.63 7671 478260669 ENN80366.1 2509 5.8e-280 hypothetical protein YQE_03225, partial [Dendroctonus ponderosae] 698430595 XM_009698856.1 46 9.38494e-12 PREDICTED: Cariama cristata ubiquitin specific peptidase 19 (USP19), partial mRNA K08734 MLH1 DNA mismatch repair protein MLH1 http://www.genome.jp/dbget-bin/www_bget?ko:K08734 P40692 1843 4.0e-204 DNA mismatch repair protein Mlh1 OS=Homo sapiens GN=MLH1 PE=1 SV=1 PF12422//PF01119//PF00443//PF05427 Condensin II non structural maintenance of chromosomes subunit//DNA mismatch repair protein, C-terminal domain//Ubiquitin carboxyl-terminal hydrolase//Acidic fibroblast growth factor binding (FIBP) GO:0006298//GO:0016579 mismatch repair//protein deubiquitination GO:0036459//GO:0005524//GO:0017134//GO:0030983 ubiquitinyl hydrolase activity//ATP binding//fibroblast growth factor binding//mismatched DNA binding GO:0005634 nucleus KOG1979 DNA mismatch repair protein - MLH1 family Cluster-8309.40762 BF_2 563.35 11.98 2254 642931533 XP_008196625.1 1634 4.9e-179 PREDICTED: WW domain-containing oxidoreductase [Tribolium castaneum] -- -- -- -- -- K19329 WWOX WW domain-containing oxidoreductase http://www.genome.jp/dbget-bin/www_bget?ko:K19329 Q9VLU5 1171 9.9e-127 WW domain-containing oxidoreductase OS=Drosophila melanogaster GN=Wwox PE=2 SV=1 PF00106//PF00397//PF02826 short chain dehydrogenase//WW domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0005515//GO:0016491//GO:0051287 protein binding//oxidoreductase activity//NAD binding -- -- -- -- Cluster-8309.40763 BF_2 42.34 3.22 838 546682146 ERL92127.1 813 2.9e-84 hypothetical protein D910_09447 [Dendroctonus ponderosae] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 P59510 468 1.2e-45 A disintegrin and metalloproteinase with thrombospondin motifs 20 OS=Homo sapiens GN=ADAMTS20 PE=2 SV=2 PF05986 ADAM-TS Spacer 1 -- -- GO:0004222 metalloendopeptidase activity GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.40764 BF_2 1.00 5.48 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40767 BF_2 690.08 2.32 12754 91083299 XP_974608.1 2229 2.8e-247 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 3.1e-193 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 PF01695//PF06414//PF00004//PF11057//PF06309 IstB-like ATP binding protein//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Cortexin of kidney//Torsin -- -- GO:0005524//GO:0016301 ATP binding//kinase activity GO:0031224 intrinsic component of membrane KOG2558 Negative regulator of histones Cluster-8309.40768 BF_2 347.71 2.94 5234 817182178 XP_012288780.1 1873 2.2e-206 PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182180|ref|XP_012288789.1| PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182182|ref|XP_012288795.1| PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182184|ref|XP_012288803.1| PREDICTED: zinc transporter 9 [Orussus abietinus]>gi|817182186|ref|XP_012288810.1| PREDICTED: zinc transporter 9 [Orussus abietinus] -- -- -- -- -- K14696 SLC30A9, ZNT9 solute carrier family 30 (zinc transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14696 Q5PQZ3 1323 5.4e-144 Zinc transporter 9 OS=Danio rerio GN=slc30a9 PE=2 SV=1 PF01545//PF00707 Cation efflux family//Translation initiation factor IF-3, C-terminal domain GO:0006812//GO:0055085//GO:0006413 cation transport//transmembrane transport//translational initiation GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG2802 Membrane protein HUEL (cation efflux superfamily) Cluster-8309.40772 BF_2 236.16 0.95 10643 642937913 XP_972695.3 1638 8.0e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.5e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40773 BF_2 852.95 6.67 5640 642916006 XP_008190854.1 2755 1.3e-308 PREDICTED: supervillin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40774 BF_2 8.58 0.36 1296 189239365 XP_970191.2 1011 4.9e-107 PREDICTED: probable chitinase 2 [Tribolium castaneum]>gi|270010475|gb|EFA06923.1| hypothetical protein TcasGA2_TC009872 [Tribolium castaneum] 827562517 XM_004933295.2 39 1.20766e-08 PREDICTED: Bombyx mori probable chitinase 2 (LOC101744821), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 656 3.0e-67 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0071704//GO:0005975 organic substance metabolic process//carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.40775 BF_2 45.47 1.60 1476 91083175 XP_972331.1 437 2.0e-40 PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|642923608|ref|XP_008193577.1| PREDICTED: beta-lactamase-like protein 2 homolog [Tribolium castaneum]>gi|270006978|gb|EFA03426.1| hypothetical protein TcasGA2_TC013413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLS9 321 2.4e-28 Beta-lactamase-like protein 2 homolog OS=Drosophila melanogaster GN=CG12375 PE=2 SV=1 PF15182 Otospiralin GO:0007605 sensory perception of sound GO:0016787 hydrolase activity -- -- KOG0813 Glyoxylase Cluster-8309.40777 BF_2 1826.52 14.51 5554 270013772 EFA10220.1 5461 0.0e+00 hypothetical protein TcasGA2_TC012416 [Tribolium castaneum] 158287295 XM_309356.4 147 4.85296e-68 Anopheles gambiae str. PEST AGAP011292-PA (AgaP_AGAP011292) mRNA, complete cds -- -- -- -- Q24020 4278 0.0e+00 Protein flightless-1 OS=Drosophila melanogaster GN=fliI PE=2 SV=1 PF13855//PF00560//PF08661 Leucine rich repeat//Leucine Rich Repeat//Replication factor A protein 3 GO:0006260//GO:0006310//GO:0006281 DNA replication//DNA recombination//DNA repair GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG0444 Cytoskeletal regulator Flightless-I (contains leucine-rich and gelsolin repeats) Cluster-8309.40780 BF_2 19.18 0.64 1535 642922284 XP_008193093.1 1153 2.0e-123 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 706 5.6e-73 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- KOG3731 Sulfatases Cluster-8309.40781 BF_2 200.36 3.84 2471 194473697 NP_001123993.1 1360 3.2e-147 cytochrome P450 CYP4BN1 [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 921 1.1e-97 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.40782 BF_2 114.81 1.14 4499 478260090 ENN79875.1 2429 6.4e-271 hypothetical protein YQE_03694, partial [Dendroctonus ponderosae]>gi|546687051|gb|ERL95966.1| hypothetical protein D910_00706 [Dendroctonus ponderosae]>gi|546687508|gb|ERL96176.1| hypothetical protein D910_01286 [Dendroctonus ponderosae]>gi|546687512|gb|ERL96179.1| hypothetical protein D910_01289 [Dendroctonus ponderosae] 170045474 XM_001850281.1 44 7.09964e-11 Culex quinquefasciatus 6-phosphofructokinase, mRNA K00850 pfkA, PFK 6-phosphofructokinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00850 P52034 1997 3.3e-222 ATP-dependent 6-phosphofructokinase OS=Drosophila melanogaster GN=Pfk PE=2 SV=2 PF00365 Phosphofructokinase GO:0006094//GO:0006000//GO:0006013//GO:0006012//GO:0006098//GO:0006096 gluconeogenesis//fructose metabolic process//mannose metabolic process//galactose metabolic process//pentose-phosphate shunt//glycolytic process GO:0003872 6-phosphofructokinase activity GO:0005945 6-phosphofructokinase complex KOG2440 Pyrophosphate-dependent phosphofructo-1-kinase Cluster-8309.40784 BF_2 121.64 2.48 2341 -- -- -- -- -- 462381300 APGK01022056.1 51 4.71332e-15 Dendroctonus ponderosae Seq01022066, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40785 BF_2 23.34 0.42 2627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40786 BF_2 501.62 2.89 7540 91090366 XP_968305.1 1722 1.0e-188 PREDICTED: T-cell immunomodulatory protein [Tribolium castaneum]>gi|270013408|gb|EFA09856.1| hypothetical protein TcasGA2_TC012004 [Tribolium castaneum] 765338960 XM_011495191.1 147 6.59665e-68 Aedes aegypti AAEL017098-RA partial mRNA K17257 ITFG1 integrin alpha FG-GAP repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17257 P18459 1010 1.5e-107 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00140//PF00351 Sigma-70 factor, region 1.2//Biopterin-dependent aromatic amino acid hydroxylase GO:0006355//GO:0055114//GO:0006352 regulation of transcription, DNA-templated//oxidation-reduction process//DNA-templated transcription, initiation GO:0016987//GO:0003700//GO:0003677//GO:0016714 sigma factor activity//transcription factor activity, sequence-specific DNA binding//DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen GO:0005667 transcription factor complex KOG3820 Aromatic amino acid hydroxylase Cluster-8309.40787 BF_2 341.11 8.36 1995 256862217 ACU77882.2 1438 2.3e-156 tyrosine hydroxylase [Tenebrio molitor] 765338960 XM_011495191.1 199 2.13785e-97 Aedes aegypti AAEL017098-RA partial mRNA K00501 TH tyrosine 3-monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00501 P18459 1241 6.7e-135 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00351 Biopterin-dependent aromatic amino acid hydroxylase GO:0055114 oxidation-reduction process GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.40788 BF_2 190.29 0.91 9022 642924959 XP_008194115.1 2763 2.4e-309 PREDICTED: coiled-coil domain-containing protein CG32809 isoform X7 [Tribolium castaneum] 642924968 XM_008195898.1 229 2.0609e-113 PREDICTED: Tribolium castaneum coiled-coil domain-containing protein AGAP005037 (LOC100141714), transcript variant X12, mRNA -- -- -- -- Q7PQ25 1220 8.2e-132 Coiled-coil domain-containing protein AGAP005037 OS=Anopheles gambiae GN=AGAP005037 PE=4 SV=4 PF02970//PF07945//PF07989//PF01025//PF15724 Tubulin binding cofactor A//Janus-atracotoxin//Centrosomin N-terminal motif 1//GrpE//TMEM119 family GO:0007021//GO:0001503//GO:0006457//GO:0009405 tubulin complex assembly//ossification//protein folding//pathogenesis GO:0000774//GO:0042803//GO:0051082//GO:0051087//GO:0015631 adenyl-nucleotide exchange factor activity//protein homodimerization activity//unfolded protein binding//chaperone binding//tubulin binding GO:0005576//GO:0005815//GO:0045298 extracellular region//microtubule organizing center//tubulin complex -- -- Cluster-8309.40789 BF_2 60.65 2.53 1290 189236107 XP_973934.2 817 1.5e-84 PREDICTED: high mobility group protein DSP1-like [Tribolium castaneum] 642918928 XM_968841.3 235 1.33068e-117 PREDICTED: Tribolium castaneum high mobility group protein DSP1-like (LOC662763), mRNA K10802 HMGB1 high mobility group protein B1 http://www.genome.jp/dbget-bin/www_bget?ko:K10802 Q24537 690 3.4e-71 High mobility group protein DSP1 OS=Drosophila melanogaster GN=Dsp1 PE=2 SV=1 PF09606//PF04961//PF15761 ARC105 or Med15 subunit of Mediator complex non-fungal//Formiminotransferase-cyclodeaminase//Immortalisation up-regulated protein GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0001104//GO:0003824 RNA polymerase II transcription cofactor activity//catalytic activity GO:0016592//GO:0005634 mediator complex//nucleus KOG0381 HMG box-containing protein Cluster-8309.40795 BF_2 635.99 16.12 1938 741829513 AJA91072.1 1000 1.4e-105 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 696 1.0e-71 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.40796 BF_2 41.10 0.62 3043 189242457 XP_970217.2 215 2.3e-14 PREDICTED: neuroglian isoform X2 [Tribolium castaneum]>gi|642939198|ref|XP_008200377.1| PREDICTED: neuroglian isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20241 184 3.8e-12 Neuroglian OS=Drosophila melanogaster GN=Nrg PE=1 SV=2 PF02979//PF05864 Nitrile hydratase, alpha chain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GO:0006206//GO:0006807//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//nitrogen compound metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003824//GO:0046914//GO:0003899 DNA binding//catalytic activity//transition metal ion binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.40798 BF_2 222.69 6.79 1660 642930262 XP_971408.3 1014 2.8e-107 PREDICTED: transmembrane protein 192 [Tribolium castaneum]>gi|270009437|gb|EFA05885.1| hypothetical protein TcasGA2_TC008697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NYE7 225 3.6e-17 Transmembrane protein 192 OS=Danio rerio GN=tmem192 PE=2 SV=1 PF04736 Eclosion hormone GO:0018990//GO:0007218 ecdysis, chitin-based cuticle//neuropeptide signaling pathway GO:0008255 ecdysis-triggering hormone activity -- -- -- -- Cluster-8309.40801 BF_2 7.57 0.37 1137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40802 BF_2 40.34 1.10 1826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40803 BF_2 213.90 1.91 4980 642912047 XP_008199070.1 2587 3.4e-289 PREDICTED: nuclear factor 1 C-type isoform X1 [Tribolium castaneum]>gi|270014496|gb|EFA10944.1| hypothetical protein TcasGA2_TC001775 [Tribolium castaneum] 642912046 XM_008200848.1 750 0 PREDICTED: Tribolium castaneum nuclear factor 1 C-type (LOC660261), transcript variant X1, mRNA K09172 NFIN nuclear factor I, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09172 P09414 752 8.4e-78 Nuclear factor 1 A-type OS=Rattus norvegicus GN=Nfia PE=1 SV=2 PF16367//PF00859//PF03165 RNA recognition motif//CTF/NF-I family transcription modulation region//MH1 domain GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0003700//GO:0003676//GO:0003677 transcription factor activity, sequence-specific DNA binding//nucleic acid binding//DNA binding GO:0005622//GO:0005667//GO:0005634 intracellular//transcription factor complex//nucleus KOG3663 Nuclear factor I Cluster-8309.40804 BF_2 1500.68 19.42 3519 478257295 ENN77458.1 3420 0.0e+00 hypothetical protein YQE_06282, partial [Dendroctonus ponderosae] 572316028 XM_006623585.1 146 1.10173e-67 PREDICTED: Apis dorsata uncharacterized LOC102670726 (LOC102670726), transcript variant X2, mRNA -- -- -- -- P48053 1295 6.4e-141 Uncharacterized protein C05D11.1 OS=Caenorhabditis elegans GN=C05D11.1 PE=4 SV=2 PF08367//PF04987 Peptidase M16C associated//Phosphatidylinositolglycan class N (PIG-N) GO:0006506//GO:0006508 GPI anchor biosynthetic process//proteolysis GO:0016740 transferase activity GO:0005789 endoplasmic reticulum membrane KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.40805 BF_2 232.85 4.42 2489 642928324 XP_008195534.1 3092 0.0e+00 PREDICTED: exocyst complex component 5 [Tribolium castaneum]>gi|270009802|gb|EFA06250.1| hypothetical protein TcasGA2_TC009108 [Tribolium castaneum] 826409849 XM_012679854.1 54 1.07808e-16 PREDICTED: Monomorium pharaonis exocyst complex component 5 (LOC105836070), mRNA -- -- -- -- Q9XTM1 1915 5.8e-213 Exocyst complex component 5 OS=Drosophila melanogaster GN=sec10 PE=2 SV=1 PF07393 Exocyst complex component Sec10 GO:0048278//GO:0006887 vesicle docking//exocytosis -- -- GO:0005737 cytoplasm KOG3745 Exocyst subunit - Sec10p Cluster-8309.40807 BF_2 1763.00 18.79 4212 820805522 AKG92752.1 837 2.4e-86 diminutive [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q17103 217 7.7e-16 Myc protein (Fragment) OS=Asterias rubens GN=MYC PE=2 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.40809 BF_2 44.10 0.56 3556 642910507 XP_008200244.1 1345 2.5e-145 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] 462373318 APGK01024789.1 85 9.04436e-34 Dendroctonus ponderosae Seq01024799, whole genome shotgun sequence K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 Q5FW38 243 6.3e-19 Nuclear factor interleukin-3-regulated protein OS=Xenopus tropicalis GN=nfil3 PE=2 SV=1 PF00170//PF07716//PF05699//PF03131 bZIP transcription factor//Basic region leucine zipper//hAT family C-terminal dimerisation region//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700//GO:0046983 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//protein dimerization activity GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3119 Basic region leucine zipper transcription factor Cluster-8309.40810 BF_2 662.00 53.17 808 642910507 XP_008200244.1 142 1.8e-06 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40815 BF_2 315.63 7.22 2115 332026895 EGI66996.1 1641 7.1e-180 Heterogeneous nuclear ribonucleoprotein Q [Acromyrmex echinatior] 642914994 XM_008192253.1 391 0 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein Q-like (LOC662503), transcript variant X5, mRNA K13160 SYNCRIP, HNRPQ heterogeneous nuclear ribonucleoprotein Q http://www.genome.jp/dbget-bin/www_bget?ko:K13160 Q7TMK9 769 3.8e-80 Heterogeneous nuclear ribonucleoprotein Q OS=Mus musculus GN=Syncrip PE=1 SV=2 PF16367//PF00076//PF11411//PF00023//PF16622 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//DNA ligase IV//Ankyrin repeat//zinc-finger C2H2-type GO:0006260//GO:0006281 DNA replication//DNA repair GO:0003676//GO:0005515//GO:0003910//GO:0046872 nucleic acid binding//protein binding//DNA ligase (ATP) activity//metal ion binding -- -- KOG0117 Heterogeneous nuclear ribonucleoprotein R (RRM superfamily) Cluster-8309.40817 BF_2 206.08 6.01 1721 642918464 XP_008191487.1 942 6.6e-99 PREDICTED: FK506-binding protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09577 FKBP14 FK506-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09577 Q54SR7 402 1.1e-37 FK506-binding protein 2 OS=Dictyostelium discoideum GN=fkbp2 PE=3 SV=1 PF10591//PF13833//PF00036//PF13405//PF13499//PF00254//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//FKBP-type peptidyl-prolyl cis-trans isomerase//EF hand GO:0007165//GO:0006457 signal transduction//protein folding GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0549 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.40818 BF_2 45.85 0.48 4256 478253821 ENN74113.1 4449 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 107 6.38873e-46 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3303 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF16656//PF01618//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//MotA/TolQ/ExbB proton channel family//Immunoglobulin domain//Fibronectin type III domain GO:0019497//GO:0006810//GO:0006771//GO:0015031 hexachlorocyclohexane metabolic process//transport//riboflavin metabolic process//protein transport GO:0005515//GO:0008565//GO:0003993//GO:0046872 protein binding//protein transporter activity//acid phosphatase activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.40819 BF_2 1713.44 10.55 7078 91092128 XP_972649.1 4445 0.0e+00 PREDICTED: splicing factor 3B subunit 3 isoform X1 [Tribolium castaneum]>gi|270004662|gb|EFA01110.1| hypothetical protein TcasGA2_TC010322 [Tribolium castaneum] 77623052 CT030548.1 392 0 Xenopus tropicalis finished cDNA, clone TGas034j22 K12830 SF3B3, SAP130, RSE1 splicing factor 3B subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12830 Q15393 3985 0.0e+00 Splicing factor 3B subunit 3 OS=Homo sapiens GN=SF3B3 PE=1 SV=4 PF13414//PF03178//PF02402 TPR repeat//CPSF A subunit region//Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0005634//GO:0019867 nucleus//outer membrane KOG1898 Splicing factor 3b, subunit 3 Cluster-8309.4082 BF_2 15.32 0.58 1394 270004026 EFA00474.1 468 4.9e-44 hypothetical protein TcasGA2_TC003333 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54P77 158 1.8e-09 Probable 4-coumarate--CoA ligase 1 OS=Dictyostelium discoideum GN=4cl1 PE=3 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.40820 BF_2 213.13 1.19 7759 91092128 XP_972649.1 5382 0.0e+00 PREDICTED: splicing factor 3B subunit 3 isoform X1 [Tribolium castaneum]>gi|270004662|gb|EFA01110.1| hypothetical protein TcasGA2_TC010322 [Tribolium castaneum] 77623052 CT030548.1 392 0 Xenopus tropicalis finished cDNA, clone TGas034j22 K12830 SF3B3, SAP130, RSE1 splicing factor 3B subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12830 A0JN52 4781 0.0e+00 Splicing factor 3B subunit 3 OS=Bos taurus GN=SF3B3 PE=2 SV=1 PF03178 CPSF A subunit region -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG1898 Splicing factor 3b, subunit 3 Cluster-8309.40821 BF_2 944.11 10.35 4103 642922013 XP_008192985.1 2785 0.0e+00 PREDICTED: argonaute-2b isoform X1 [Tribolium castaneum] -- -- -- -- -- K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q8CJG0 1392 4.3e-152 Protein argonaute-2 OS=Mus musculus GN=Ago2 PE=1 SV=3 PF02170//PF02171 PAZ domain//Piwi domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.40822 BF_2 698.34 4.25 7168 642912301 XP_968800.3 1228 1.9e-131 PREDICTED: protein couch potato isoform X2 [Tribolium castaneum] 642912300 XM_963707.3 407 0 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X2, mRNA -- -- -- -- Q01617 796 9.6e-83 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.40825 BF_2 40.93 0.32 5616 642913783 XP_008201159.1 1313 2.0e-141 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.86782e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 1200 1.1e-129 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF03611//PF01562 PTS system sugar-specific permease component//Reprolysin family propeptide GO:0006508//GO:0009401 proteolysis//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.40828 BF_2 20.83 0.62 1685 642932834 XP_008197005.1 1294 9.8e-140 PREDICTED: uncharacterized protein LOC663161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40829 BF_2 338.05 4.65 3326 189237751 XP_001812575.1 2171 3.9e-241 PREDICTED: sorting nexin-13-like [Tribolium castaneum]>gi|642924410|ref|XP_008194284.1| PREDICTED: sorting nexin-13-like [Tribolium castaneum] -- -- -- -- -- K17925 SNX13 sorting nexin-13 http://www.genome.jp/dbget-bin/www_bget?ko:K17925 Q6PHS6 787 4.9e-82 Sorting nexin-13 OS=Mus musculus GN=Snx13 PE=2 SV=1 PF00787//PF00316 PX domain//Fructose-1-6-bisphosphatase GO:0006094//GO:0015976//GO:0005975//GO:0006000//GO:0006013//GO:0006096//GO:0006098 gluconeogenesis//carbon utilization//carbohydrate metabolic process//fructose metabolic process//mannose metabolic process//glycolytic process//pentose-phosphate shunt GO:0042578//GO:0042132//GO:0035091 phosphoric ester hydrolase activity//fructose 1,6-bisphosphate 1-phosphatase activity//phosphatidylinositol binding -- -- KOG2992 Nucleolar GTPase/ATPase p130 Cluster-8309.40830 BF_2 32.83 0.51 2986 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.40832 BF_2 17.37 0.39 2130 642917916 XP_008191381.1 712 3.8e-72 PREDICTED: methyltransferase-like protein 17, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U2U7 296 2.7e-25 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF02285//PF12326//PF09243 Cytochrome oxidase c subunit VIII//N-glycosylation protein//Mitochondrial small ribosomal subunit Rsm22 GO:0015992//GO:0034599//GO:0006412//GO:0006123 proton transport//cellular response to oxidative stress//translation//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277//GO:0005789 respiratory chain complex IV//endoplasmic reticulum membrane KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.40833 BF_2 1074.04 19.94 2540 859132804 AKO63317.1 1918 6.5e-212 3-hydroxy-3-methylglutaryl coenzyme A synthase [Leptinotarsa decemlineata] -- -- -- -- -- K01641 E2.3.3.10 hydroxymethylglutaryl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01641 P54961 1642 2.7e-181 Hydroxymethylglutaryl-CoA synthase 1 OS=Blattella germanica GN=HMGCS-1 PE=2 SV=1 PF01154//PF08540 Hydroxymethylglutaryl-coenzyme A synthase N terminal//Hydroxymethylglutaryl-coenzyme A synthase C terminal GO:0006574//GO:0006550//GO:0046950//GO:0006084//GO:0006552//GO:0008299 valine catabolic process//isoleucine catabolic process//cellular ketone body metabolic process//acetyl-CoA metabolic process//leucine catabolic process//isoprenoid biosynthetic process GO:0004421 hydroxymethylglutaryl-CoA synthase activity -- -- KOG1393 Hydroxymethylglutaryl-CoA synthase Cluster-8309.40834 BF_2 15.52 0.52 1526 91090452 XP_967359.1 569 1.0e-55 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|642935319|ref|XP_008197966.1| PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013849|gb|EFA10297.1| hypothetical protein TcasGA2_TC012512 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T674 175 2.1e-11 ABC transporter G family member 20 OS=Dictyostelium discoideum GN=abcG20 PE=3 SV=1 PF00931//PF03205//PF01637//PF00006//PF01926//PF00005//PF03193 NB-ARC domain//Molybdopterin guanine dinucleotide synthesis protein B//Archaeal ATPase//ATP synthase alpha/beta family, nucleotide-binding domain//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0006200//GO:0006810//GO:0006777 obsolete ATP catabolic process//transport//Mo-molybdopterin cofactor biosynthetic process GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0042626 ATP binding//ADP binding//GTPase activity//GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.40835 BF_2 53.15 0.57 4187 91079768 XP_966889.1 628 4.1e-62 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08699 275 1.4e-22 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.40836 BF_2 28.62 0.56 2427 642919248 XP_008191793.1 163 2.0e-08 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0044765 single-organism transport -- -- -- -- -- -- Cluster-8309.40838 BF_2 1287.17 4.84 11414 642935532 XP_008198047.1 1716 7.7e-188 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Tribolium castaneum]>gi|270013328|gb|EFA09776.1| hypothetical protein TcasGA2_TC011918 [Tribolium castaneum] 755889203 XM_005188558.2 102 1.03628e-42 PREDICTED: Musca domestica vesicular integral-membrane protein VIP36 (LOC101894935), mRNA K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q7L273 1027 2.5e-109 BTB/POZ domain-containing protein KCTD9 OS=Homo sapiens GN=KCTD9 PE=1 SV=1 PF02017//PF00139//PF02214//PF03388 CIDE-N domain//Legume lectin domain//BTB/POZ domain//Legume-like lectin family GO:0046854//GO:0051260//GO:0006915 phosphatidylinositol phosphorylation//protein homooligomerization//apoptotic process GO:0030246 carbohydrate binding GO:0005622//GO:0016020 intracellular//membrane KOG3839 Lectin VIP36, involved in the transport of glycoproteins carrying high mannose-type glycans Cluster-8309.40841 BF_2 112.93 0.97 5166 390198528 AFL70631.1 2282 8.2e-254 putative hypoxia-inducible factor 1 alpha [Callosobruchus maculatus] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 Q24167 843 2.4e-88 Protein similar OS=Drosophila melanogaster GN=sima PE=1 SV=2 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG3558 Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 Cluster-8309.40842 BF_2 5207.30 17.95 12426 91092464 XP_970082.1 4337 0.0e+00 PREDICTED: glycine dehydrogenase (decarboxylating), mitochondrial [Tribolium castaneum]>gi|270004725|gb|EFA01173.1| hypothetical protein TcasGA2_TC010496 [Tribolium castaneum] 332372930 BT126644.1 662 0 Dendroctonus ponderosae clone DPO0411_K02 unknown mRNA K00281 GLDC, gcvP glycine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00281 P23378 3262 0.0e+00 Glycine dehydrogenase (decarboxylating), mitochondrial OS=Homo sapiens GN=GLDC PE=1 SV=2 PF01176//PF02347//PF01053//PF01212//PF00344 Translation initiation factor 1A / IF-1//Glycine cleavage system P-protein//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//SecY translocase GO:0006544//GO:0006546//GO:0006520//GO:0006413//GO:0006446//GO:0055114//GO:0015031//GO:0006566//GO:0006563 glycine metabolic process//glycine catabolic process//cellular amino acid metabolic process//translational initiation//regulation of translational initiation//oxidation-reduction process//protein transport//threonine metabolic process//L-serine metabolic process GO:0004375//GO:0030170//GO:0003723//GO:0016829//GO:0003743 glycine dehydrogenase (decarboxylating) activity//pyridoxal phosphate binding//RNA binding//lyase activity//translation initiation factor activity GO:0016020//GO:0005840 membrane//ribosome KOG2040 Glycine dehydrogenase (decarboxylating) Cluster-8309.40843 BF_2 2278.05 7.72 12632 642913168 XP_008201419.1 3497 0.0e+00 PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum]>gi|642913170|ref|XP_008201420.1| PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum] 642913399 XM_008202772.1 149 8.56038e-69 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X3, mRNA K10358 MYO6 myosin VI http://www.genome.jp/dbget-bin/www_bget?ko:K10358 Q01989 2938 0.0e+00 Myosin heavy chain 95F OS=Drosophila melanogaster GN=jar PE=2 SV=4 PF13465//PF06459//PF02487//PF01363//PF13912//PF02736//PF02892//PF02724//PF01943//PF00437//PF00096//PF05672//PF00612//PF00063 Zinc-finger double domain//Ryanodine Receptor TM 4-6//CLN3 protein//FYVE zinc finger//C2H2-type zinc finger//Myosin N-terminal SH3-like domain//BED zinc finger//CDC45-like protein//Polysaccharide biosynthesis protein//Type II/IV secretion system protein//Zinc finger, C2H2 type//MAP7 (E-MAP-115) family//IQ calmodulin-binding motif//Myosin head (motor domain) GO:0000226//GO:0000271//GO:0006874//GO:0006816//GO:0006270//GO:0006810 microtubule cytoskeleton organization//polysaccharide biosynthetic process//cellular calcium ion homeostasis//calcium ion transport//DNA replication initiation//transport GO:0003774//GO:0046872//GO:0003677//GO:0005219//GO:0005515//GO:0005524 motor activity//metal ion binding//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding//ATP binding GO:0016020//GO:0005622//GO:0016459//GO:0016021//GO:0015630 membrane//intracellular//myosin complex//integral component of membrane//microtubule cytoskeleton KOG0163 Myosin class VI heavy chain Cluster-8309.40844 BF_2 253.60 9.15 1447 443725752 ELU13203.1 1077 1.2e-114 hypothetical protein CAPTEDRAFT_149382 [Capitella teleta] -- -- -- -- -- K01805 xylA xylose isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01805 Q9FKK7 810 4.6e-85 Xylose isomerase OS=Arabidopsis thaliana GN=XYLA PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40845 BF_2 5234.92 221.91 1274 270013979 EFA10427.1 523 1.9e-50 hypothetical protein TcasGA2_TC012668 [Tribolium castaneum] 642935879 XM_008199988.1 39 1.18659e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103314310 (LOC103314310), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40846 BF_2 615.35 16.99 1802 189238341 XP_966817.2 1777 1.0e-195 PREDICTED: sorting and assembly machinery component 50 homolog [Tribolium castaneum] -- -- -- -- -- K07277 SAM50, TOB55, bamA outer membrane protein insertion porin family http://www.genome.jp/dbget-bin/www_bget?ko:K07277 Q6PA35 910 1.5e-96 Sorting and assembly machinery component 50 homolog B OS=Xenopus laevis GN=samm50-b PE=2 SV=1 PF01103 Surface antigen -- -- -- -- GO:0019867 outer membrane KOG2602 Predicted cell surface protein homologous to bacterial outer membrane proteins Cluster-8309.40848 BF_2 882.29 26.18 1697 270015668 EFA12116.1 687 2.4e-69 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8CEE7 455 7.9e-44 Retinol dehydrogenase 13 OS=Mus musculus GN=Rdh13 PE=2 SV=1 PF01370//PF00106//PF01073//PF07465 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//Photosystem I protein M (PsaM) GO:0008152//GO:0008210//GO:0015979//GO:0008207//GO:0006694//GO:0055114//GO:0008209 metabolic process//estrogen metabolic process//photosynthesis//C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process GO:0003854//GO:0050662//GO:0003824//GO:0016616//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- -- -- Cluster-8309.40849 BF_2 273.24 1.96 6132 642929348 XP_008195797.1 3118 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1646 2.2e-181 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF09111//PF08352//PF00225//PF00787//PF00498 SLIDE//Oligopeptide/dipeptide transporter, C-terminal region//Kinesin motor domain//PX domain//FHA domain GO:0015833//GO:0007017//GO:0006338//GO:0007018 peptide transport//microtubule-based process//chromatin remodeling//microtubule-based movement GO:0016818//GO:0003676//GO:0008017//GO:0000166//GO:0035091//GO:0005515//GO:0003777//GO:0005524 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//microtubule binding//nucleotide binding//phosphatidylinositol binding//protein binding//microtubule motor activity//ATP binding GO:0045298//GO:0005874//GO:0005634 tubulin complex//microtubule//nucleus KOG0245 Kinesin-like protein Cluster-8309.40852 BF_2 18.00 4.82 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40853 BF_2 1299.93 43.30 1543 242117921 NP_001155991.1 1638 1.2e-179 rhodopsin 1/6-like [Tribolium castaneum]>gi|270007219|gb|EFA03667.1| hypothetical protein TcasGA2_TC013765 [Tribolium castaneum] 197259972 EU921225.1 214 7.54515e-106 Thermonectus marmoratus putative long wavelength opsin mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 P35362 1521 1.8e-167 Rhodopsin OS=Sphodromantis sp. PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0007165//GO:0007601//GO:0018298//GO:0007602 G-protein coupled receptor signaling pathway//signal transduction//visual perception//protein-chromophore linkage//phototransduction GO:0009881//GO:0004930 photoreceptor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.40854 BF_2 156.44 1.15 5955 189233727 XP_970593.2 2892 0.0e+00 PREDICTED: AP-3 complex subunit beta-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12397 AP3B AP-3 complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12397 Q13367 2115 9.0e-236 AP-3 complex subunit beta-2 OS=Homo sapiens GN=AP3B2 PE=1 SV=2 PF13374//PF02862//PF00515//PF09726//PF13371//PF00330//PF02535//PF02985//PF02486//PF13414//PF13181//PF01602//PF13174//PF08492 Tetratricopeptide repeat//DDHD domain//Tetratricopeptide repeat//Transmembrane protein//Tetratricopeptide repeat//Aconitase family (aconitate hydratase)//ZIP Zinc transporter//HEAT repeat//Replication initiation factor//TPR repeat//Tetratricopeptide repeat//Adaptin N terminal region//Tetratricopeptide repeat//SRP72 RNA-binding domain GO:0008152//GO:0030001//GO:0006265//GO:0006614//GO:0055085//GO:0006270//GO:0016192//GO:0006886 metabolic process//metal ion transport//DNA topological change//SRP-dependent cotranslational protein targeting to membrane//transmembrane transport//DNA replication initiation//vesicle-mediated transport//intracellular protein transport GO:0008312//GO:0046873//GO:0046872//GO:0003677//GO:0003916//GO:0005515 7S RNA binding//metal ion transmembrane transporter activity//metal ion binding//DNA binding//DNA topoisomerase activity//protein binding GO:0016020//GO:0030117//GO:0016021//GO:0048500 membrane//membrane coat//integral component of membrane//signal recognition particle KOG1060 Vesicle coat complex AP-3, beta subunit Cluster-8309.40855 BF_2 81.55 0.59 6051 429327037 AFZ78847.1 288 1.6e-22 putative cysteine-rich protein 1 [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- P36201 235 9.1e-18 Cysteine-rich protein 2 OS=Rattus norvegicus GN=Crip2 PE=2 SV=1 PF02188 GoLoco motif -- -- GO:0030695 GTPase regulator activity -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.40857 BF_2 154.23 3.99 1903 91086285 XP_967226.1 1304 7.7e-141 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 946 1.0e-100 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.40859 BF_2 4174.62 94.56 2134 546681329 ERL91443.1 1890 9.6e-209 hypothetical protein D910_08773 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 284 6.7e-24 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 PF01155//PF06905//PF00856 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Fas apoptotic inhibitory molecule (FAIM1)//SET domain GO:0006464//GO:0043066 cellular protein modification process//negative regulation of apoptotic process GO:0005515//GO:0016151 protein binding//nickel cation binding -- -- -- -- Cluster-8309.40860 BF_2 101.88 1.27 3646 642934083 XP_008196496.1 1036 1.8e-109 PREDICTED: phosphatase and actin regulator 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.6e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00957//PF00344//PF04940 Synaptobrevin//SecY translocase//Sensors of blue-light using FAD GO:0016192//GO:0015031//GO:0007165 vesicle-mediated transport//protein transport//signal transduction GO:0009882//GO:0071949 blue light photoreceptor activity//FAD binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.40861 BF_2 64.19 0.60 4752 531444638 AGT57836.1 1136 5.8e-121 cytochrome P450 412a1 [Leptinotarsa decemlineata] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 823 4.7e-86 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067//PF07535 Cytochrome P450//DBF zinc finger GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705//GO:0008270//GO:0003676 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.40862 BF_2 31.62 2.12 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40866 BF_2 217.44 1.23 7687 642939018 XP_008198083.1 835 7.5e-86 PREDICTED: protein SCAF8 isoform X2 [Tribolium castaneum] 195123078 XM_002006001.1 64 9.27248e-22 Drosophila mojavensis GI18767 (Dmoj\GI18767), mRNA K13191 RBM16, SCAF8 RNA-binding protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13191 Q6DID3 568 2.8e-56 Protein SCAF8 OS=Mus musculus GN=Scaf8 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0132 RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains Cluster-8309.40867 BF_2 1140.44 7.26 6858 642939018 XP_008198083.1 1297 1.8e-139 PREDICTED: protein SCAF8 isoform X2 [Tribolium castaneum] 195123078 XM_002006001.1 64 8.26765e-22 Drosophila mojavensis GI18767 (Dmoj\GI18767), mRNA K13191 RBM16, SCAF8 RNA-binding protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13191 Q6DID3 568 2.5e-56 Protein SCAF8 OS=Mus musculus GN=Scaf8 PE=1 SV=1 PF01080//PF00076 Presenilin//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG0132 RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains Cluster-8309.40870 BF_2 5342.00 612.48 652 91087441 XP_975685.1 238 1.1e-17 PREDICTED: B1 protein [Tribolium castaneum]>gi|270010982|gb|EFA07430.1| odorant binding protein (subfamily minus-C) C04 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27018 236 7.5e-19 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF03033//PF01395 Glycosyltransferase family 28 N-terminal domain//PBP/GOBP family GO:0005975//GO:0030259 carbohydrate metabolic process//lipid glycosylation GO:0016758//GO:0005549 transferase activity, transferring hexosyl groups//odorant binding -- -- -- -- Cluster-8309.40871 BF_2 1222.47 8.43 6355 91081951 XP_967254.1 2017 5.4e-223 PREDICTED: LIM domain-containing protein jub isoform X2 [Tribolium castaneum]>gi|270007323|gb|EFA03771.1| hypothetical protein TcasGA2_TC013882 [Tribolium castaneum] 170045329 XM_001850215.1 328 1.34067e-168 Culex quinquefasciatus limd1, mRNA K16682 AJUBA, LIMD1, WTIP LIM domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K16682 Q9VY77 1217 1.3e-131 LIM domain-containing protein jub OS=Drosophila melanogaster GN=jub PE=1 SV=3 PF00400//PF04185//PF00412 WD domain, G-beta repeat//Phosphoesterase family//LIM domain -- -- GO:0005515//GO:0016788//GO:0008270//GO:0043169 protein binding//hydrolase activity, acting on ester bonds//zinc ion binding//cation binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.40873 BF_2 32.33 0.92 1753 91081285 XP_967895.1 685 4.2e-69 PREDICTED: soma ferritin [Tribolium castaneum]>gi|270005213|gb|EFA01661.1| hypothetical protein TcasGA2_TC007233 [Tribolium castaneum] -- -- -- -- -- K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P42577 552 4.6e-55 Soma ferritin OS=Lymnaea stagnalis PE=2 SV=2 PF00210//PF02915 Ferritin-like domain//Rubrerythrin GO:0006826//GO:0055114//GO:0006879 iron ion transport//oxidation-reduction process//cellular iron ion homeostasis GO:0016491//GO:0046872//GO:0008199 oxidoreductase activity//metal ion binding//ferric iron binding -- -- KOG2332 Ferritin Cluster-8309.40874 BF_2 1162.54 16.40 3253 189234994 XP_969025.2 2102 3.8e-233 PREDICTED: protein SMG7-like [Tribolium castaneum] -- -- -- -- -- K14409 SMG7, EST1C protein SMG7 http://www.genome.jp/dbget-bin/www_bget?ko:K14409 Q92540 806 3.0e-84 Protein SMG7 OS=Homo sapiens GN=SMG7 PE=1 SV=2 PF07776//PF13181//PF13414//PF13176 Zinc-finger associated domain (zf-AD)//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus KOG2162 Nonsense-mediated mRNA decay protein Cluster-8309.40875 BF_2 57.89 0.70 3739 642934158 XP_968636.2 1148 1.8e-122 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 680 1.4e-69 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151//PF01805 GNS1/SUR4 family//Surp module GO:0006396 RNA processing GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.40876 BF_2 672.13 7.67 3953 642939400 XP_008193248.1 467 1.8e-43 PREDICTED: uncharacterized protein LOC103312106 [Tribolium castaneum]>gi|270016475|gb|EFA12921.1| hypothetical protein TcasGA2_TC006991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40880 BF_2 25.35 0.33 3536 91079020 XP_974879.1 1898 1.9e-209 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q863B3 1012 4.2e-108 Staphylococcal nuclease domain-containing protein 1 OS=Bos taurus GN=SND1 PE=1 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.40883 BF_2 468.46 4.76 4403 478255294 ENN75520.1 4929 0.0e+00 hypothetical protein YQE_07864, partial [Dendroctonus ponderosae] 585685897 XM_006820162.1 113 3.05425e-49 PREDICTED: Saccoglossus kowalevskii brefeldin A-inhibited guanine nucleotide-exchange protein 1-like (LOC100366823), mRNA K18442 ARFGEF, BIG brefeldin A-inhibited guanine nucleotide-exchange protein http://www.genome.jp/dbget-bin/www_bget?ko:K18442 Q9Y6D6 3777 0.0e+00 Brefeldin A-inhibited guanine nucleotide-exchange protein 1 OS=Homo sapiens GN=ARFGEF1 PE=1 SV=2 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.40884 BF_2 2155.28 21.10 4561 270008370 EFA04818.1 1154 4.6e-123 hypothetical protein TcasGA2_TC014868 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8SWR8 600 3.3e-60 Ataxin-2 homolog OS=Drosophila melanogaster GN=Atx2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2375 Protein interacting with poly(A)-binding protein Cluster-8309.40886 BF_2 118.48 7.23 973 270013731 EFA10179.1 908 3.3e-95 hypothetical protein TcasGA2_TC012371 [Tribolium castaneum] -- -- -- -- -- K13142 INTS5 integrator complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13142 Q6P9B9 285 2.3e-24 Integrator complex subunit 5 OS=Homo sapiens GN=INTS5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40887 BF_2 17.00 41.25 1434 241598585 XP_002404762.1 314 3.6e-26 ADP ribosylation factor 79F, putative [Ixodes scapularis]>gi|215500482|gb|EEC09976.1| ADP ribosylation factor 79F, putative [Ixodes scapularis] 642935820 XM_008199967.1 116 2.1037e-51 PREDICTED: Tribolium castaneum ADP-ribosylation factor 1 (LOC656788), transcript variant X3, mRNA K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 P0CM17 306 1.3e-26 ADP-ribosylation factor OS=Cryptococcus neoformans var. neoformans serotype D (strain B-3501A) GN=ARF PE=3 SV=1 PF08477//PF01239//PF00503//PF04670//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein prenyltransferase alpha subunit repeat//G-protein alpha subunit//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ras family GO:0007264//GO:0007186//GO:0018342//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//protein prenylation//signal transduction GO:0004871//GO:0019001//GO:0008318//GO:0005525//GO:0003924//GO:0031683 signal transducer activity//guanyl nucleotide binding//protein prenyltransferase activity//GTP binding//GTPase activity//G-protein beta/gamma-subunit complex binding GO:0005622 intracellular KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.40888 BF_2 252.92 1.49 7390 91083005 XP_974497.1 1587 4.6e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit H [Tribolium castaneum]>gi|270007645|gb|EFA04093.1| hypothetical protein TcasGA2_TC014327 [Tribolium castaneum] -- -- -- -- -- K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1431 2.3e-156 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF01398//PF04961//PF00622//PF07525//PF09596 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//SPRY domain//SOCS box//MamL-1 domain GO:0035556//GO:0007219//GO:0045944//GO:0044237 intracellular signal transduction//Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0005515//GO:0003713 catalytic activity//protein binding//transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-8309.40889 BF_2 121.99 2.59 2259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4089 BF_2 16.00 2.11 605 221136975 NP_001137600.1 151 1.2e-07 gustatory receptor [Tribolium castaneum]>gi|642925349|ref|XP_008194515.1| PREDICTED: gustatory receptor [Tribolium castaneum]>gi|163716744|gb|ABY40596.1| gustatory receptor [Tribolium castaneum]>gi|270009332|gb|EFA05780.1| gustatory receptor 70 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395//PF06151 7tm Chemosensory receptor//Trehalose receptor GO:0007607//GO:0050909//GO:0007187//GO:0050912 obsolete taste perception//sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.40893 BF_2 23.96 0.98 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40894 BF_2 355.25 4.32 3731 546677329 ERL88186.1 1326 4.2e-143 hypothetical protein D910_05574 [Dendroctonus ponderosae] -- -- -- -- -- K17407 MRPS28 small subunit ribosomal protein S28 http://www.genome.jp/dbget-bin/www_bget?ko:K17407 Q9CY16 323 3.5e-28 28S ribosomal protein S28, mitochondrial OS=Mus musculus GN=Mrps28 PE=1 SV=1 PF06788 Uncharacterised protein family (UPF0257) -- -- -- -- GO:0005886 plasma membrane KOG4078 Putative mitochondrial ribosomal protein mRpS35 Cluster-8309.40895 BF_2 1103.00 9.10 5355 91084933 XP_970918.1 4699 0.0e+00 PREDICTED: DNA-directed RNA polymerase I subunit RPA1 [Tribolium castaneum]>gi|270008555|gb|EFA05003.1| hypothetical protein TcasGA2_TC015082 [Tribolium castaneum] 593716780 XM_007104772.1 122 3.69384e-54 PREDICTED: Physeter catodon polymerase (RNA) I polypeptide A, 194kDa (POLR1A), mRNA K02999 RPA1, POLR1A DNA-directed RNA polymerase I subunit RPA1 http://www.genome.jp/dbget-bin/www_bget?ko:K02999 P91875 3292 0.0e+00 DNA-directed RNA polymerase I subunit RPA1 OS=Drosophila melanogaster GN=RpI1 PE=1 SV=2 PF04983//PF05000//PF04147//PF04998//PF02724//PF04997//PF07168//PF00623 RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//Nop14-like family//RNA polymerase Rpb1, domain 5//CDC45-like protein//RNA polymerase Rpb1, domain 1//Ureide permease//RNA polymerase Rpb1, domain 2 GO:0071705//GO:0006351//GO:0006270//GO:0006144//GO:0006206 nitrogen compound transport//transcription, DNA-templated//DNA replication initiation//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0008270 DNA binding//DNA-directed RNA polymerase activity//zinc ion binding GO:0005634//GO:0005730//GO:0032040 nucleus//nucleolus//small-subunit processome KOG0262 RNA polymerase I, large subunit Cluster-8309.40896 BF_2 61.00 1.85 1663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40897 BF_2 303.60 11.25 1416 478249904 ENN70411.1 502 5.7e-48 hypothetical protein YQE_12917, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH14 183 2.3e-12 Tissue inhibitor of metalloproteases OS=Drosophila melanogaster GN=Timp PE=2 SV=1 PF00965//PF13673 Tissue inhibitor of metalloproteinase//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0008191 N-acetyltransferase activity//metalloendopeptidase inhibitor activity -- -- -- -- Cluster-8309.40898 BF_2 1010.95 38.91 1374 546677533 ERL88352.1 606 4.8e-60 hypothetical protein D910_05739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH14 273 8.1e-23 Tissue inhibitor of metalloproteases OS=Drosophila melanogaster GN=Timp PE=2 SV=1 PF13673//PF00965 Acetyltransferase (GNAT) domain//Tissue inhibitor of metalloproteinase GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0008191 N-acetyltransferase activity//metalloendopeptidase inhibitor activity -- -- -- -- Cluster-8309.40899 BF_2 140.76 8.70 964 642913085 XP_008201384.1 581 2.7e-57 PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum]>gi|642913087|ref|XP_008201386.1| PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum] 642913086 XM_008203164.1 219 7.73394e-109 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X9, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 314 1.0e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.409 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40901 BF_2 1500.79 32.12 2242 741829289 AJA91071.1 1466 1.5e-159 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1061 5.6e-114 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.40903 BF_2 114.48 0.45 10999 642918318 XP_008191457.1 7327 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 195492470 XM_002093969.1 257 6.84408e-129 Drosophila yakuba GE20438 (Dyak\GE20438), partial mRNA -- -- -- -- Q9VS29 6236 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF07749//PF16656//PF13895//PF04120//PF00041 Endoplasmic reticulum protein ERp29, C-terminal domain//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Low affinity iron permease//Fibronectin type III domain GO:0019497//GO:0006771//GO:0055085 hexachlorocyclohexane metabolic process//riboflavin metabolic process//transmembrane transport GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.40905 BF_2 225.82 11.02 1144 642915944 XP_008190822.1 472 1.4e-44 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X1 [Tribolium castaneum]>gi|270003748|gb|EFA00196.1| hypothetical protein TcasGA2_TC003021 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00PI9 157 1.9e-09 Heterogeneous nuclear ribonucleoprotein U-like protein 2 OS=Mus musculus GN=Hnrnpul2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40907 BF_2 878.11 14.26 2864 642918268 XP_008191439.1 1540 5.0e-168 PREDICTED: methoprene-tolerant isoform X1 [Tribolium castaneum]>gi|207367000|dbj|BAG71980.1| methoprene-tolerant [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZQU2 294 6.2e-25 Neuronal PAS domain-containing protein 2 OS=Gallus gallus GN=NPAS2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0003677//GO:0005515//GO:0046983//GO:0004871//GO:0003700 DNA binding//protein binding//protein dimerization activity//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005737 transcription factor complex//cytoplasm -- -- Cluster-8309.40908 BF_2 224.05 2.24 4471 642927501 XP_008195294.1 965 3.7e-101 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26, partial [Tribolium castaneum] -- -- -- -- -- K17914 KIF13 kinesin family member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K17914 -- -- -- -- PF03427 Carbohydrate binding domain (family 19) GO:0006032 chitin catabolic process GO:0008061 chitin binding -- -- -- -- Cluster-8309.40909 BF_2 26.00 1.23 1174 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40910 BF_2 287.33 3.14 4115 91081613 XP_966546.1 1370 3.7e-148 PREDICTED: protein goliath-like [Tribolium castaneum] 768414717 XM_011549573.1 128 1.30864e-57 PREDICTED: Plutella xylostella protein goliath (LOC105380077), mRNA -- -- -- -- Q06003 711 3.9e-73 Protein goliath OS=Drosophila melanogaster GN=gol PE=2 SV=3 PF13639//PF00335//PF12861//PF06667//PF12678//PF17123//PF14634//PF00097 Ring finger domain//Tetraspanin family//Anaphase-promoting complex subunit 11 RING-H2 finger//Phage shock protein B//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0006355//GO:0016567//GO:0009271 regulation of transcription, DNA-templated//protein ubiquitination//phage shock GO:0046872//GO:0008270//GO:0004842//GO:0005515 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding GO:0005680//GO:0016021 anaphase-promoting complex//integral component of membrane KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.40911 BF_2 60.65 0.67 4101 91081613 XP_966546.1 1370 3.7e-148 PREDICTED: protein goliath-like [Tribolium castaneum] 768414717 XM_011549573.1 128 1.30415e-57 PREDICTED: Plutella xylostella protein goliath (LOC105380077), mRNA -- -- -- -- Q06003 711 3.9e-73 Protein goliath OS=Drosophila melanogaster GN=gol PE=2 SV=3 PF13639//PF00335//PF12861//PF06667//PF00097//PF17123//PF12678//PF14634 Ring finger domain//Tetraspanin family//Anaphase-promoting complex subunit 11 RING-H2 finger//Phage shock protein B//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain GO:0009271//GO:0016567//GO:0006355 phage shock//protein ubiquitination//regulation of transcription, DNA-templated GO:0004842//GO:0005515//GO:0008270//GO:0046872 ubiquitin-protein transferase activity//protein binding//zinc ion binding//metal ion binding GO:0016021//GO:0005680 integral component of membrane//anaphase-promoting complex KOG4628 Predicted E3 ubiquitin ligase Cluster-8309.40912 BF_2 272.29 1.47 8055 642931705 XP_008196694.1 6622 0.0e+00 PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum]>gi|642931707|ref|XP_008196695.1| PREDICTED: serine/threonine-protein kinase ATR [Tribolium castaneum] -- -- -- -- -- K06640 ATR serine/threonine-protein kinase ATR http://www.genome.jp/dbget-bin/www_bget?ko:K06640 Q9VXG8 2331 1.1e-260 Serine/threonine-protein kinase ATR OS=Drosophila melanogaster GN=mei-41 PE=1 SV=2 PF00454//PF02260//PF08064//PF02259 Phosphatidylinositol 3- and 4-kinase//FATC domain//UME (NUC010) domain//FAT domain GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0005515//GO:0004674 phosphotransferase activity, alcohol group as acceptor//protein binding//protein serine/threonine kinase activity -- -- KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination Cluster-8309.40914 BF_2 11.00 5.44 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09297 NADH pyrophosphatase zinc ribbon domain -- -- GO:0046872//GO:0016787 metal ion binding//hydrolase activity -- -- -- -- Cluster-8309.40915 BF_2 294.80 3.03 4362 642912192 XP_008200846.1 754 1.1e-76 PREDICTED: transmembrane protein 127-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGP5 216 1.0e-15 Transmembrane protein 127 OS=Mus musculus GN=Tmem127 PE=2 SV=1 PF00515//PF04799 Tetratricopeptide repeat//fzo-like conserved region GO:0008053 mitochondrial fusion GO:0003924//GO:0005515 GTPase activity//protein binding GO:0005741//GO:0016021 mitochondrial outer membrane//integral component of membrane -- -- Cluster-8309.40916 BF_2 26.69 0.39 3167 478251864 ENN72303.1 1127 4.3e-120 hypothetical protein YQE_11046, partial [Dendroctonus ponderosae]>gi|546674377|gb|ERL85764.1| hypothetical protein D910_03179 [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 2.1e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.40917 BF_2 51.96 0.65 3617 91084681 XP_968452.1 2285 2.6e-254 PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925779|ref|XP_008201721.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925781|ref|XP_008201727.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|642925783|ref|XP_008190266.1| PREDICTED: solute carrier family 26 member 10 isoform X2 [Tribolium castaneum]>gi|270008928|gb|EFA05376.1| hypothetical protein TcasGA2_TC015542 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q8CIW6 923 9.1e-98 Solute carrier family 26 member 6 OS=Mus musculus GN=Slc26a6 PE=1 SV=2 PF00916 Sulfate permease family GO:0008272//GO:0044765 sulfate transport//single-organism transport GO:0015116 sulfate transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.40919 BF_2 74.02 1.32 2629 642912272 XP_008200632.1 843 3.0e-87 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00187 253 3.2e-20 Mannan-binding lectin serine protease 2 OS=Homo sapiens GN=MASP2 PE=1 SV=4 PF00089//PF04272//PF01414 Trypsin//Phospholamban//Delta serrate ligand GO:0006508//GO:0007154//GO:0006816//GO:0006810 proteolysis//cell communication//calcium ion transport//transport GO:0004252//GO:0005246//GO:0042030 serine-type endopeptidase activity//calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.40921 BF_2 68.00 7.75 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40922 BF_2 960.57 24.30 1941 546678980 ERL89513.1 1262 5.8e-136 hypothetical protein D910_06879 [Dendroctonus ponderosae] 850318596 XM_013007893.1 39 1.82538e-08 PREDICTED: Echinops telfairi L-lactate dehydrogenase A chain-like (LOC101645051), mRNA K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1148 3.9e-124 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF02737//PF02866//PF00056//PF03721//PF02427 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//lactate/malate dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Photosystem I reaction centre subunit IV / PsaE GO:0006574//GO:0006550//GO:0055114//GO:0006554//GO:0006568//GO:0006633//GO:0018874//GO:0015979//GO:0006552//GO:0006631 valine catabolic process//isoleucine catabolic process//oxidation-reduction process//lysine catabolic process//tryptophan metabolic process//fatty acid biosynthetic process//benzoate metabolic process//photosynthesis//leucine catabolic process//fatty acid metabolic process GO:0016616//GO:0003857//GO:0051287//GO:0016491 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-hydroxyacyl-CoA dehydrogenase activity//NAD binding//oxidoreductase activity GO:0009522//GO:0009538 photosystem I//photosystem I reaction center KOG1495 Lactate dehydrogenase Cluster-8309.40923 BF_2 15.73 0.39 1972 642935798 XP_008198179.1 371 1.2e-32 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- K06489 CD53, MOX44, TSPAN25 CD53 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06489 Q3ZCD0 149 2.8e-08 CD81 antigen OS=Bos taurus GN=CD81 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.40925 BF_2 1329.93 5.11 11181 270015748 EFA12196.1 1838 5.4e-202 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TT16 248 5.2e-19 Inositol polyphosphate multikinase OS=Mus musculus GN=Ipmk PE=2 SV=1 PF16716//PF05529//PF00096//PF00867//PF03770//PF00695//PF04111//PF01218//PF08702//PF01105//PF10473//PF00642//PF03938//PF13912 Bone marrow stromal antigen 2//B-cell receptor-associated protein 31-like//Zinc finger, C2H2 type//XPG I-region//Inositol polyphosphate kinase//Major surface antigen from hepadnavirus//Autophagy protein Apg6//Coproporphyrinogen III oxidase//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Outer membrane protein (OmpH-like)//C2H2-type zinc finger GO:0030168//GO:0015994//GO:0051607//GO:0016032//GO:0006779//GO:0055114//GO:0006810//GO:0006886//GO:0006914//GO:0051258//GO:0007165 platelet activation//chlorophyll metabolic process//defense response to virus//viral process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//transport//intracellular protein transport//autophagy//protein polymerization//signal transduction GO:0046872//GO:0004518//GO:0030674//GO:0042803//GO:0004109//GO:0005102//GO:0008440//GO:0051082//GO:0045502//GO:0008134 metal ion binding//nuclease activity//protein binding, bridging//protein homodimerization activity//coproporphyrinogen oxidase activity//receptor binding//inositol-1,4,5-trisphosphate 3-kinase activity//unfolded protein binding//dynein binding//transcription factor binding GO:0005783//GO:0005667//GO:0030286//GO:0005577//GO:0016021 endoplasmic reticulum//transcription factor complex//dynein complex//fibrinogen complex//integral component of membrane -- -- Cluster-8309.40926 BF_2 2.00 1.44 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40927 BF_2 305.00 5.07 2806 642921258 XP_008192788.1 1049 4.2e-111 PREDICTED: serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [Tribolium castaneum] 573910381 XM_006642846.1 210 2.31845e-103 PREDICTED: Lepisosteus oculatus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC102696354), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q5I085 1017 8.9e-109 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Xenopus tropicalis GN=ppp1cb PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.40928 BF_2 1642.95 19.96 3730 91082177 XP_971147.1 608 7.6e-60 PREDICTED: transmembrane protein 35 [Tribolium castaneum]>gi|270007236|gb|EFA03684.1| hypothetical protein TcasGA2_TC013786 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9T5 193 4.2e-13 Transmembrane protein 35 OS=Bos taurus GN=TMEM35 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40929 BF_2 284.05 3.44 3741 91082177 XP_971147.1 602 3.8e-59 PREDICTED: transmembrane protein 35 [Tribolium castaneum]>gi|270007236|gb|EFA03684.1| hypothetical protein TcasGA2_TC013786 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IGI5 191 7.1e-13 Transmembrane protein 35 OS=Xenopus tropicalis GN=tmem35 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40930 BF_2 24.15 0.36 3107 642920332 XP_975626.2 1424 1.5e-154 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] 195397078 XM_002057120.1 100 3.6196e-42 Drosophila virilis GJ16936 (Dvir\GJ16936), mRNA -- -- -- -- Q6TYB5 388 8.5e-36 Fasciculation and elongation protein zeta-2 OS=Mus musculus GN=Fez2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.40934 BF_2 613.11 12.99 2261 642924570 XP_008194348.1 691 1.1e-69 PREDICTED: probable signal peptidase complex subunit 2 [Tribolium castaneum]>gi|270006751|gb|EFA03199.1| hypothetical protein TcasGA2_TC013119 [Tribolium castaneum] -- -- -- -- -- K12947 SPCS2, SPC2 signal peptidase complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12947 Q28250 519 4.0e-51 Signal peptidase complex subunit 2 OS=Canis familiaris GN=SPCS2 PE=1 SV=1 PF06703 Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0016021//GO:0005787 integral component of membrane//signal peptidase complex -- -- Cluster-8309.40935 BF_2 1012.77 18.77 2544 91083815 XP_973428.1 297 6.0e-24 PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924518|ref|XP_008194328.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|642924520|ref|XP_008194329.1| PREDICTED: chromobox protein homolog 5 [Tribolium castaneum]>gi|270007930|gb|EFA04378.1| hypothetical protein TcasGA2_TC014676 [Tribolium castaneum] 242011614 XM_002426498.1 39 2.40287e-08 Pediculus humanus corporis hypothetical protein, mRNA K11587 CBX5, HP1A chromobox protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11587 Q61686 246 2.0e-19 Chromobox protein homolog 5 OS=Mus musculus GN=Cbx5 PE=1 SV=1 PF04689//PF01393 DNA binding protein S1FA//Chromo shadow domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.40936 BF_2 289.51 1.35 9244 642912276 XP_008200634.1 5209 0.0e+00 PREDICTED: exportin-7 isoform X2 [Tribolium castaneum]>gi|270002549|gb|EEZ98996.1| hypothetical protein TcasGA2_TC004857 [Tribolium castaneum] 642912275 XM_008202412.1 985 0 PREDICTED: Tribolium castaneum exportin-7 (LOC655656), transcript variant X2, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 4020 0.0e+00 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF03810//PF13414 Importin-beta N-terminal domain//TPR repeat GO:0006886//GO:0015031 intracellular protein transport//protein transport GO:0008536//GO:0005515//GO:0008565 Ran GTPase binding//protein binding//protein transporter activity GO:0005643 nuclear pore KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.40938 BF_2 15.00 10.82 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40940 BF_2 1062.54 4.98 9209 270002460 EEZ98907.1 4932 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF01363//PF07649 Zn-finger in ubiquitin-hydrolases and other protein//FYVE zinc finger//C1-like domain GO:0055114 oxidation-reduction process GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.40941 BF_2 1072.76 9.13 5203 642911378 XP_008199399.1 1861 5.4e-205 PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911380|ref|XP_008199400.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911382|ref|XP_008199401.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911384|ref|XP_008199402.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911386|ref|XP_008199403.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum]>gi|642911388|ref|XP_008199404.1| PREDICTED: myocyte-specific enhancer factor 2 isoform X1 [Tribolium castaneum] 642911387 XM_008201182.1 520 0 PREDICTED: Tribolium castaneum myocyte-specific enhancer factor 2 (LOC660448), transcript variant X6, mRNA K09263 MEF2N MADS-box transcription enhancer factor 2, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09263 P40791 941 1.1e-99 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF03554//PF00319 UL73 viral envelope glycoprotein//SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.40942 BF_2 314.29 13.01 1298 478255506 ENN75723.1 727 4.2e-74 hypothetical protein YQE_07683, partial [Dendroctonus ponderosae]>gi|546676756|gb|ERL87712.1| hypothetical protein D910_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K02939 RP-L9, MRPL9, rplI large subunit ribosomal protein L9 http://www.genome.jp/dbget-bin/www_bget?ko:K02939 Q9VF89 604 3.2e-61 39S ribosomal protein L9, mitochondrial OS=Drosophila melanogaster GN=mRpL9 PE=2 SV=1 PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG4607 Mitochondrial ribosomal protein L9 Cluster-8309.40944 BF_2 64.36 0.55 5177 332372780 AEE61532.1 1204 8.2e-129 unknown [Dendroctonus ponderosae] 564241437 XM_006277474.1 68 3.72504e-24 PREDICTED: Alligator mississippiensis sideroflexin-1-like (LOC102569899), mRNA -- -- -- -- Q5E9M8 908 7.1e-96 Sideroflexin-1 OS=Bos taurus GN=SFXN1 PE=2 SV=3 PF03820 Tricarboxylate carrier GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.40945 BF_2 254.43 1.28 8582 642926988 XP_008195092.1 1922 7.5e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 5.93231e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K09750 TMPRSS11A transmembrane protease, serine 11A http://www.genome.jp/dbget-bin/www_bget?ko:K09750 P21902 290 5.4e-24 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF02468//PF00089 Photosystem II reaction centre N protein (psbN)//Trypsin GO:0015979//GO:0006508 photosynthesis//proteolysis GO:0004252 serine-type endopeptidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.40946 BF_2 22.97 1.06 1191 91081119 XP_975527.1 773 1.8e-79 PREDICTED: lipoyl synthase, mitochondrial [Tribolium castaneum]>gi|270006027|gb|EFA02475.1| hypothetical protein TcasGA2_TC008166 [Tribolium castaneum] 675228061 LK023128.1 51 2.36279e-15 Plasmodium berghei ANKA genome assembly PBANKA01, chromosome : 13 K03644 lipA lipoic acid synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K03644 B3NIL9 702 1.3e-72 Lipoyl synthase, mitochondrial OS=Drosophila erecta GN=Las PE=3 SV=1 PF04055 Radical SAM superfamily GO:0044238//GO:0044237//GO:0071704 primary metabolic process//cellular metabolic process//organic substance metabolic process GO:0016783//GO:0051536//GO:0003824 sulfurtransferase activity//iron-sulfur cluster binding//catalytic activity -- -- KOG2672 Lipoate synthase Cluster-8309.40949 BF_2 36.37 0.35 4650 642913457 XP_008201020.1 4027 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2251 1.2e-251 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00784//PF00023 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.40951 BF_2 877.69 5.33 7182 642936633 XP_008198516.1 3023 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936632 XM_008200294.1 364 0 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X1, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 2.3e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF02262//PF08702//PF01496//PF04513//PF15182//PF06009//PF04111 CBL proto-oncogene N-terminal domain 1//Fibrinogen alpha/beta chain family//V-type ATPase 116kDa subunit family//Baculovirus polyhedron envelope protein, PEP, C terminus//Otospiralin//Laminin Domain II//Autophagy protein Apg6 GO:0007155//GO:0030168//GO:0015991//GO:0015992//GO:0007166//GO:0007165//GO:0006914//GO:0051258//GO:0007605 cell adhesion//platelet activation//ATP hydrolysis coupled proton transport//proton transport//cell surface receptor signaling pathway//signal transduction//autophagy//protein polymerization//sensory perception of sound GO:0030674//GO:0004871//GO:0015078//GO:0005102//GO:0005198 protein binding, bridging//signal transducer activity//hydrogen ion transmembrane transporter activity//receptor binding//structural molecule activity GO:0033179//GO:0005634//GO:0019031//GO:0005577//GO:0019028 proton-transporting V-type ATPase, V0 domain//nucleus//viral envelope//fibrinogen complex//viral capsid -- -- Cluster-8309.40952 BF_2 94.24 4.28 1209 546672885 ERL84608.1 986 3.6e-104 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 816 7.7e-86 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107//PF00106 Zinc-binding dehydrogenase//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.40953 BF_2 73.15 0.98 3423 189234059 XP_969658.2 2716 2.6e-304 PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|642911998|ref|XP_008199054.1| PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|270014437|gb|EFA10885.1| hypothetical protein TcasGA2_TC001709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TWI9 1057 2.5e-113 CSC1-like protein 2 OS=Mus musculus GN=Tmem63b PE=1 SV=1 PF02714 Calcium-dependent channel, 7TM region, putative phosphate -- -- -- -- GO:0016020 membrane KOG1134 Uncharacterized conserved protein Cluster-8309.40954 BF_2 36.47 0.53 3149 642934087 XP_008196609.1 1036 1.5e-109 PREDICTED: phosphatase and actin regulator 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.4e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0015031//GO:0016192 protein transport//vesicle-mediated transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4339 RPEL repeat-containing protein Cluster-8309.40955 BF_2 704.10 55.91 814 642926727 XP_008194988.1 442 3.0e-41 PREDICTED: phenoloxidase subunit A3 [Tribolium castaneum]>gi|270009214|gb|EFA05662.1| hypothetical protein TcasGA2_TC014907 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V521 402 5.3e-38 Phenoloxidase 2 OS=Drosophila melanogaster GN=PPO2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40956 BF_2 623.13 2.63 10188 270003787 EFA00235.1 2422 9.4e-270 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 462304009 APGK01049651.1 110 3.30205e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 871 2.7e-91 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF08176//PF01637//PF03193//PF02899//PF00005//PF13895//PF00041//PF16656//PF13304//PF01926//PF01061//PF07714//PF00621//PF00069//PF03931 Small acid-soluble spore protein K family//Archaeal ATPase//Protein of unknown function, DUF258//Phage integrase, N-terminal SAM-like domain//ABC transporter//Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC-2 type transporter//Protein tyrosine kinase//RhoGEF domain//Protein kinase domain//Skp1 family, tetramerisation domain GO:0030436//GO:0019497//GO:0006468//GO:0035023//GO:0015074//GO:0043087//GO:0006771//GO:0006511 asexual sporulation//hexachlorocyclohexane metabolic process//protein phosphorylation//regulation of Rho protein signal transduction//DNA integration//regulation of GTPase activity//riboflavin metabolic process//ubiquitin-dependent protein catabolic process GO:0003993//GO:0016887//GO:0003924//GO:0005524//GO:0004672//GO:0046872//GO:0005089//GO:0005525//GO:0005515//GO:0003677 acid phosphatase activity//ATPase activity//GTPase activity//ATP binding//protein kinase activity//metal ion binding//Rho guanyl-nucleotide exchange factor activity//GTP binding//protein binding//DNA binding GO:0042601//GO:0016020 endospore-forming forespore//membrane -- -- Cluster-8309.40957 BF_2 359.40 5.21 3175 820805526 AKG92754.1 881 1.4e-91 usf [Leptinotarsa decemlineata] 641661239 XM_008183586.1 156 2.74122e-73 PREDICTED: Acyrthosiphon pisum chromatin modifying protein 2A (Chmp2a), transcript variant X7, mRNA K12191 CHMP2A charged multivesicular body protein 2A http://www.genome.jp/dbget-bin/www_bget?ko:K12191 Q6DFS6 458 6.6e-44 Charged multivesicular body protein 2a OS=Xenopus tropicalis GN=chmp2a PE=2 SV=1 PF04152//PF05848//PF04420//PF06156//PF05615//PF01346//PF06729//PF03357//PF00010 Mre11 DNA-binding presumed domain//Firmicute transcriptional repressor of class III stress genes (CtsR)//CHD5-like protein//Protein of unknown function (DUF972)//Tho complex subunit 7//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Kinetochore component, CENP-R//Snf7//Helix-loop-helix DNA-binding domain GO:0007034//GO:0006302//GO:0006355//GO:0071816//GO:0006260//GO:0034080//GO:0006950//GO:0006397//GO:0006457 vacuolar transport//double-strand break repair//regulation of transcription, DNA-templated//tail-anchored membrane protein insertion into ER membrane//DNA replication//CENP-A containing nucleosome assembly//response to stress//mRNA processing//protein folding GO:0046983//GO:0030145//GO:0004519//GO:0003677 protein dimerization activity//manganese ion binding//endonuclease activity//DNA binding GO:0000445//GO:0005634 THO complex part of transcription export complex//nucleus KOG3230 Vacuolar assembly/sorting protein DID4 Cluster-8309.40959 BF_2 88.26 1.54 2689 270003134 EEZ99581.1 841 5.3e-87 hypothetical protein TcasGA2_TC001567 [Tribolium castaneum] -- -- -- -- -- K13196 DPF2, REQ zinc finger protein ubi-d4 http://www.genome.jp/dbget-bin/www_bget?ko:K13196 Q61103 255 1.9e-20 Zinc finger protein ubi-d4 OS=Mus musculus GN=Dpf2 PE=1 SV=1 PF02064 MAS20 protein import receptor GO:0006886//GO:0006605 intracellular protein transport//protein targeting -- -- GO:0005742 mitochondrial outer membrane translocase complex KOG4056 Translocase of outer mitochondrial membrane complex, subunit TOM20 Cluster-8309.40961 BF_2 327.00 12.47 1384 91091780 XP_969605.1 1011 5.3e-107 PREDICTED: ubiquitin thioesterase OTU1 [Tribolium castaneum]>gi|270000841|gb|EEZ97288.1| hypothetical protein TcasGA2_TC011093 [Tribolium castaneum] -- -- -- -- -- K13719 OTU1, YOD1 ubiquitin thioesterase OTU1 http://www.genome.jp/dbget-bin/www_bget?ko:K13719 Q5F3A6 606 2.0e-61 Ubiquitin thioesterase OTU1 OS=Gallus gallus GN=YOD1 PE=2 SV=1 PF00240//PF00789 Ubiquitin family//UBX domain -- -- GO:0005515 protein binding -- -- KOG3288 OTU-like cysteine protease Cluster-8309.40963 BF_2 69.12 0.63 4845 642929394 XP_008195818.1 1810 4.1e-199 PREDICTED: neogenin isoform X2 [Tribolium castaneum] -- -- -- -- -- K06766 NEO1 neogenin http://www.genome.jp/dbget-bin/www_bget?ko:K06766 Q90610 949 1.2e-100 Neogenin (Fragment) OS=Gallus gallus PE=2 SV=1 PF00041//PF08465//PF06583//PF16656//PF01108 Fibronectin type III domain//Thymidine kinase from Herpesvirus C-terminal//Neogenin C-terminus//Purple acid Phosphatase, N-terminal domain//Tissue factor GO:0019497//GO:0006230//GO:0006206//GO:0006771 hexachlorocyclohexane metabolic process//TMP biosynthetic process//pyrimidine nucleobase metabolic process//riboflavin metabolic process GO:0005515//GO:0004797//GO:0005524//GO:0046872//GO:0003993 protein binding//thymidine kinase activity//ATP binding//metal ion binding//acid phosphatase activity GO:0016021 integral component of membrane KOG4221 Receptor mediating netrin-dependent axon guidance Cluster-8309.40965 BF_2 76.59 1.02 3413 332375404 AEE62843.1 1194 7.8e-128 unknown [Dendroctonus ponderosae] 642934692 XM_008199551.1 353 0 PREDICTED: Tribolium castaneum CUGBP Elav-like family member 1 (LOC660275), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q9IBD0 376 2.3e-34 CUGBP Elav-like family member 1 OS=Danio rerio GN=celf1 PE=1 SV=1 PF08675//PF00076//PF16367 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.40966 BF_2 532.26 11.29 2259 332375404 AEE62843.1 1194 5.2e-128 unknown [Dendroctonus ponderosae] 817215516 XM_012428466.1 65 7.49972e-23 PREDICTED: Orussus abietinus CUGBP Elav-like family member 4 (LOC105701602), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q9IBD0 376 1.5e-34 CUGBP Elav-like family member 1 OS=Danio rerio GN=celf1 PE=1 SV=1 PF08675//PF00076//PF16367 RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0004535//GO:0003676//GO:0046872 RNA binding//poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding GO:0005634//GO:0005737 nucleus//cytoplasm KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.40967 BF_2 416.01 9.95 2037 642928504 XP_008193818.1 2050 2.6e-227 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2K6 941 4.2e-100 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.40968 BF_2 992.00 7.39 5902 642937173 XP_008198722.1 3541 0.0e+00 PREDICTED: myosin-11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYY4 139 1.2e-06 Uveal autoantigen with coiled-coil domains and ankyrin repeats protein OS=Bos taurus GN=UACA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.40969 BF_2 65.39 0.41 6985 642920223 XP_975548.2 2830 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.7e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF01180//PF00170//PF02183 Dihydroorotate dehydrogenase//bZIP transcription factor//Homeobox associated leucine zipper GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0016627//GO:0003700//GO:0043565 oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.40970 BF_2 773.44 10.54 3356 270011492 EFA07940.1 3322 0.0e+00 hypothetical protein TcasGA2_TC005521 [Tribolium castaneum] 759067243 XM_011344784.1 294 5.6042e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 6.8e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF07533//PF13185//PF13492//PF01590//PF00233 BRK domain//GAF domain//GAF domain//GAF domain//3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0005515//GO:0016817//GO:0004114 protein binding//hydrolase activity, acting on acid anhydrides//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.40971 BF_2 56.14 1.36 2020 573896974 XP_006636225.1 150 5.3e-07 PREDICTED: tissue factor pathway inhibitor 2-like [Lepisosteus oculatus] -- -- -- -- -- -- -- -- -- C0HJF3 141 2.4e-07 Analgesic polypeptide HC3 OS=Heteractis crispa PE=1 SV=1 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4295 Serine proteinase inhibitor (KU family) Cluster-8309.40974 BF_2 96.45 0.49 8571 546674242 ERL85667.1 1294 5.0e-139 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q9VHN9 477 1.1e-45 Hermansky-Pudlak syndrome 5 protein homolog OS=Drosophila melanogaster GN=p PE=2 SV=1 PF13639//PF12678 Ring finger domain//RING-H2 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.40975 BF_2 122.54 0.70 7645 546674242 ERL85667.1 1294 4.4e-139 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 735 1.2e-75 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 PF00097//PF12678//PF17123//PF14634//PF09773//PF12861//PF13639//PF07967 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//Meckelin (Transmembrane protein 67)//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//C3HC zinc finger-like GO:0016567//GO:0010826//GO:0042384 protein ubiquitination//negative regulation of centrosome duplication//cilium assembly GO:0005515//GO:0004842//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//metal ion binding//zinc ion binding GO:0005680//GO:0005634//GO:0036038 anaphase-promoting complex//nucleus//TCTN-B9D complex KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.40976 BF_2 78.71 0.83 4263 270010219 EFA06667.1 2551 4.3e-285 hypothetical protein TcasGA2_TC009594 [Tribolium castaneum] -- -- -- -- -- K15046 NS1BP influenza virus NS1A-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K15046 Q9Y6Y0 951 6.1e-101 Influenza virus NS1A-binding protein OS=Homo sapiens GN=IVNS1ABP PE=1 SV=3 PF01344//PF07646//PF00651 Kelch motif//Kelch motif//BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.40977 BF_2 441.66 11.79 1854 642918280 XP_008191442.1 1219 5.4e-131 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 642918281 XM_008193221.1 276 3.11522e-140 PREDICTED: Tribolium castaneum UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (LOC655930), transcript variant X2, mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 1102 8.1e-119 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13176//PF13414//PF02259//PF13374//PF00515//PF13371//PF13174//PF07721//PF13181 Tetratricopeptide repeat//TPR repeat//FAT domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.40979 BF_2 3656.24 18.02 8775 642934775 XP_008197803.1 5779 0.0e+00 PREDICTED: helicase domino [Tribolium castaneum] 642934782 XM_963533.2 436 0 PREDICTED: Tribolium castaneum uncharacterized LOC657045 (LOC657045), mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 3079 0.0e+00 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.40980 BF_2 391.45 4.73 3749 478257589 ENN77743.1 1238 6.8e-133 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 792 1.5e-82 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF02325//PF13241//PF01408//PF03435//PF00389//PF00899//PF02826//PF03446//PF02254 YGGT family//Putative NAD(P)-binding//Oxidoreductase family, NAD-binding Rossmann fold//Saccharopine dehydrogenase NADP binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//TrkA-N domain GO:0055114//GO:0006779//GO:0019521//GO:0006813//GO:0006098//GO:0019354//GO:0008152 oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process//potassium ion transport//pentose-phosphate shunt//siroheme biosynthetic process//metabolic process GO:0008641//GO:0004616//GO:0016616//GO:0051287//GO:0016491//GO:0043115 small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity//precorrin-2 dehydrogenase activity GO:0016020 membrane KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.40981 BF_2 67.66 2.37 1482 642933447 XP_008197423.1 572 4.5e-56 PREDICTED: bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 P18155 404 5.6e-38 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Mus musculus GN=Mthfd2 PE=1 SV=1 PF00763//PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0004488//GO:0003824 methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.40982 BF_2 165.47 0.71 10043 642912633 XP_008200941.1 4778 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q5H8C4 2035 2.9e-226 Vacuolar protein sorting-associated protein 13A OS=Mus musculus GN=Vps13a PE=2 SV=1 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.40984 BF_2 56.55 0.40 6168 546670634 ERL83320.1 5541 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.5498e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 P35125 1367 5.1e-149 Ubiquitin carboxyl-terminal hydrolase 6 OS=Homo sapiens GN=USP6 PE=1 SV=2 PF13499//PF05191//PF00036//PF13405//PF06337//PF11421//PF00443 EF-hand domain pair//Adenylate kinase, active site lid//EF hand//EF-hand domain//DUSP domain//ATP synthase F1 beta subunit//Ubiquitin carboxyl-terminal hydrolase GO:0006144//GO:0046034//GO:0006508//GO:0016579//GO:0006754 purine nucleobase metabolic process//ATP metabolic process//proteolysis//protein deubiquitination//ATP biosynthetic process GO:0004843//GO:0036459//GO:0005524//GO:0016887//GO:0005509//GO:0004017 ubiquitin-specific protease activity//ubiquitinyl hydrolase activity//ATP binding//ATPase activity//calcium ion binding//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.40989 BF_2 2397.85 17.94 5878 642932082 XP_008196850.1 2434 2.2e-271 PREDICTED: zinc finger with UFM1-specific peptidase domain protein-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 1037 8.9e-111 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 PF00096//PF13465//PF08465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Thymidine kinase from Herpesvirus C-terminal//C2H2-type zinc finger GO:0006206//GO:0006230 pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0046872//GO:0005524//GO:0004797 metal ion binding//ATP binding//thymidine kinase activity -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.40990 BF_2 2370.89 16.61 6258 642916856 XP_968783.3 1187 9.3e-127 PREDICTED: zinc finger protein on ecdysone puffs [Tribolium castaneum] 242023932 XM_002432340.1 66 5.82909e-23 Pediculus humanus corporis proteasome subunit beta type, putative, mRNA K02732 PSMB1 20S proteasome subunit beta 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02732 P40304 767 1.9e-79 Proteasome subunit beta type-1 OS=Drosophila melanogaster GN=Prosbeta6 PE=2 SV=2 PF13673//PF00096//PF00227//PF13413//PF04988//PF01381//PF12844//PF13912 Acetyltransferase (GNAT) domain//Zinc finger, C2H2 type//Proteasome subunit//Helix-turn-helix domain//A-kinase anchoring protein 95 (AKAP95)//Helix-turn-helix//Helix-turn-helix domain//C2H2-type zinc finger GO:0051603//GO:0042967 proteolysis involved in cellular protein catabolic process//acyl-carrier-protein biosynthetic process GO:0004298//GO:0046872//GO:0043565//GO:0008080//GO:0003677 threonine-type endopeptidase activity//metal ion binding//sequence-specific DNA binding//N-acetyltransferase activity//DNA binding GO:0005839//GO:0005634 proteasome core complex//nucleus KOG0179 20S proteasome, regulatory subunit beta type PSMB1/PRE7 Cluster-8309.40992 BF_2 18.00 12.99 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.40993 BF_2 58.54 3.72 945 642932847 XP_008197010.1 466 5.7e-44 PREDICTED: NAD kinase-like isoform X2 [Tribolium castaneum] 751793735 XM_011208255.1 87 1.81064e-35 PREDICTED: Bactrocera dorsalis NAD kinase (LOC105228428), transcript variant X3, mRNA K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 O95544 294 2.0e-25 NAD kinase OS=Homo sapiens GN=NADK PE=1 SV=1 PF01513//PF01017 ATP-NAD kinase//STAT protein, all-alpha domain GO:0007165//GO:0008152//GO:0046497//GO:0006355//GO:0006741//GO:0006769 signal transduction//metabolic process//nicotinate nucleotide metabolic process//regulation of transcription, DNA-templated//NADP biosynthetic process//nicotinamide metabolic process GO:0003951//GO:0004871//GO:0003700 NAD+ kinase activity//signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2178 Predicted sugar kinase Cluster-8309.40994 BF_2 806.04 9.41 3869 642932845 XP_008197009.1 1536 2.0e-167 PREDICTED: NAD kinase-like isoform X1 [Tribolium castaneum] 751793735 XM_011208255.1 75 3.56733e-28 PREDICTED: Bactrocera dorsalis NAD kinase (LOC105228428), transcript variant X3, mRNA K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 P58058 997 2.5e-106 NAD kinase OS=Mus musculus GN=Nadk PE=1 SV=2 PF01513//PF00781 ATP-NAD kinase//Diacylglycerol kinase catalytic domain GO:0006741//GO:0008152//GO:0046497//GO:0006769 NADP biosynthetic process//metabolic process//nicotinate nucleotide metabolic process//nicotinamide metabolic process GO:0016301//GO:0003951 kinase activity//NAD+ kinase activity -- -- KOG2178 Predicted sugar kinase Cluster-8309.40995 BF_2 1883.18 7.43 10893 642918112 XP_008194047.1 2422 1.0e-269 PREDICTED: calpain-B isoform X2 [Tribolium castaneum] 751219340 XM_011164448.1 186 1.99424e-89 PREDICTED: Solenopsis invicta calpain-A-like (LOC105197860), transcript variant X10, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 1916 2.0e-212 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF13499//PF13405//PF13833//PF00036//PF12763//PF13202//PF00648 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand//Calpain family cysteine protease GO:0006508 proteolysis GO:0005509//GO:0005515//GO:0004198 calcium ion binding//protein binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.40996 BF_2 63.17 0.40 6840 270002551 EEZ98998.1 3806 0.0e+00 hypothetical protein TcasGA2_TC004859 [Tribolium castaneum] 827549416 XM_004927285.2 162 2.74369e-76 PREDICTED: Bombyx mori tankyrase (LOC101740141), mRNA K10799 TNKS tankyrase http://www.genome.jp/dbget-bin/www_bget?ko:K10799 Q9VBP3 3110 0.0e+00 Tankyrase OS=Drosophila melanogaster GN=Tnks PE=1 SV=1 PF00023//PF00322//PF13606//PF00536//PF00644//PF07647 Ankyrin repeat//Endothelin family//Ankyrin repeat//SAM domain (Sterile alpha motif)//Poly(ADP-ribose) polymerase catalytic domain//SAM domain (Sterile alpha motif) GO:0019229 regulation of vasoconstriction GO:0005515//GO:0003950 protein binding//NAD+ ADP-ribosyltransferase activity GO:0005576 extracellular region -- -- Cluster-8309.40997 BF_2 2084.86 69.45 1543 270011004 EFA07452.1 827 1.3e-85 serine protease P91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 496 1.3e-48 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.40999 BF_2 815.00 18.26 2154 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41001 BF_2 570.58 27.95 1141 91087251 XP_975522.1 560 8.6e-55 PREDICTED: uncharacterized protein LOC664422 [Tribolium castaneum]>gi|270009553|gb|EFA06001.1| hypothetical protein TcasGA2_TC008827 [Tribolium castaneum] -- -- -- -- -- K04402 GADD45 growth arrest and DNA-damage-inducible protein http://www.genome.jp/dbget-bin/www_bget?ko:K04402 Q2KIX1 132 1.5e-06 Growth arrest and DNA damage-inducible protein GADD45 gamma OS=Bos taurus GN=GADD45G PE=2 SV=1 PF05733 Tenuivirus/Phlebovirus nucleocapsid protein GO:0051726//GO:0006950 regulation of cell cycle//response to stress GO:0003723 RNA binding GO:0005634//GO:0019013 nucleus//viral nucleocapsid -- -- Cluster-8309.41002 BF_2 22.29 0.50 2143 91080995 XP_975051.1 1754 5.7e-193 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] 731415861 XM_010661396.1 41 1.56066e-09 PREDICTED: Vitis vinifera calreticulin (LOC100256319), transcript variant X2, mRNA K08054 CANX calnexin http://www.genome.jp/dbget-bin/www_bget?ko:K08054 P35565 1297 2.3e-141 Calnexin OS=Rattus norvegicus GN=Canx PE=1 SV=1 PF00262 Calreticulin family GO:0006457 protein folding GO:0051082//GO:0005509 unfolded protein binding//calcium ion binding GO:0005783 endoplasmic reticulum KOG0675 Calnexin Cluster-8309.41004 BF_2 137.98 1.34 4604 642915302 XP_008190562.1 1416 1.9e-153 PREDICTED: JNK-interacting protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04436 MAPK8IP3, JIP3 mitogen-activated protein kinase 8 interacting protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04436 O60271 993 8.8e-106 C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens GN=SPAG9 PE=1 SV=4 PF03178 CPSF A subunit region -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.41008 BF_2 521.55 26.39 1114 478256566 ENN76750.1 510 5.3e-49 hypothetical protein YQE_06815, partial [Dendroctonus ponderosae]>gi|546680028|gb|ERL90390.1| hypothetical protein D910_07739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05793//PF09726//PF07393//PF01101 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Transmembrane protein//Exocyst complex component Sec10//HMG14 and HMG17 GO:0006367//GO:0048278//GO:0006887//GO:0032968 transcription initiation from RNA polymerase II promoter//vesicle docking//exocytosis//positive regulation of transcription elongation from RNA polymerase II promoter GO:0031492//GO:0003677 nucleosomal DNA binding//DNA binding GO:0005737//GO:0005634//GO:0000785//GO:0016021 cytoplasm//nucleus//chromatin//integral component of membrane -- -- Cluster-8309.41014 BF_2 179.88 4.71 1885 642920515 XP_008192382.1 1537 7.3e-168 PREDICTED: TWiK family of potassium channels protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 367 1.4e-33 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF07830//PF00520//PF01007 Protein serine/threonine phosphatase 2C, C-terminal domain//Ion transport protein//Inward rectifier potassium channel GO:0006813//GO:0006470//GO:0055085//GO:0006811 potassium ion transport//protein dephosphorylation//transmembrane transport//ion transport GO:0005242//GO:0030145//GO:0004721//GO:0000287//GO:0005216 inward rectifier potassium channel activity//manganese ion binding//phosphoprotein phosphatase activity//magnesium ion binding//ion channel activity GO:0016021//GO:0008076//GO:0016020 integral component of membrane//voltage-gated potassium channel complex//membrane -- -- Cluster-8309.41016 BF_2 176.26 7.73 1241 642917126 XP_008191126.1 603 9.6e-60 PREDICTED: uncharacterized protein LOC659233 [Tribolium castaneum]>gi|270003488|gb|EEZ99935.1| hypothetical protein TcasGA2_TC002731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41017 BF_2 629.00 4.62 5985 642929257 XP_008195757.1 2695 1.2e-301 PREDICTED: enhancer of polycomb homolog 1 [Tribolium castaneum] 642929256 XM_008197535.1 558 0 PREDICTED: Tribolium castaneum enhancer of polycomb homolog 1 (LOC103313670), mRNA K11322 EPC enhancer of polycomb-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11322 Q8C9X6 1053 1.3e-112 Enhancer of polycomb homolog 1 OS=Mus musculus GN=Epc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2261 Polycomb enhancer protein, EPC Cluster-8309.41018 BF_2 61.25 1.24 2351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4102 BF_2 7.00 0.33 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41020 BF_2 390.84 4.53 3897 642928441 XP_008193786.1 225 2.1e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41021 BF_2 198.05 1.00 8569 478253260 ENN73631.1 10407 0.0e+00 hypothetical protein YQE_09878, partial [Dendroctonus ponderosae] 751798243 XM_011210726.1 68 6.18013e-24 PREDICTED: Bactrocera dorsalis protein furry-like (LOC105230123), mRNA -- -- -- -- O94915 4680 0.0e+00 Protein furry homolog-like OS=Homo sapiens GN=FRYL PE=1 SV=2 PF05510//PF02140//PF09201 Sarcoglycan alpha/epsilon//Galactose binding lectin domain//SRX, signal recognition particle receptor alpha subunit -- -- GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0016012 sarcoglycan complex KOG1825 Fry-like conserved proteins Cluster-8309.41022 BF_2 433.00 6.70 2992 642931889 XP_008196769.1 3735 0.0e+00 PREDICTED: protein HID1 [Tribolium castaneum]>gi|270012240|gb|EFA08688.1| hypothetical protein TcasGA2_TC006359 [Tribolium castaneum] 755988842 XM_011313686.1 188 4.19909e-91 PREDICTED: Fopius arisanus protein HID1 (LOC105271879), mRNA -- -- -- -- Q8R1F6 2846 0.0e+00 Protein HID1 OS=Mus musculus GN=Hid1 PE=1 SV=1 PF02291 Transcription initiation factor IID, 31kD subunit GO:0006352 DNA-templated transcription, initiation -- -- -- -- KOG2226 Proteins containing regions of low-complexity Cluster-8309.41023 BF_2 28.96 0.57 2424 642913085 XP_008201384.1 581 6.7e-57 PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum]>gi|642913087|ref|XP_008201386.1| PREDICTED: disks large 1 tumor suppressor protein isoform X8 [Tribolium castaneum] 642913086 XM_008203164.1 219 1.98609e-108 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X9, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 314 2.5e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.41025 BF_2 181.36 2.76 3040 546678022 ERL88746.1 1049 4.5e-111 hypothetical protein D910_06128 [Dendroctonus ponderosae] -- -- -- -- -- K01784 galE, GALE UDP-glucose 4-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01784 Q9W0P5 742 7.4e-77 UDP-glucose 4-epimerase OS=Drosophila melanogaster GN=Gale PE=1 SV=1 PF01073//PF00106//PF03435//PF01370//PF02254 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//TrkA-N domain GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008152//GO:0008210//GO:0006813 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//metabolic process//estrogen metabolic process//potassium ion transport GO:0003854//GO:0050662//GO:0003824//GO:0016616//GO:0016491 3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1371 UDP-glucose 4-epimerase/UDP-sulfoquinovose synthase Cluster-8309.41028 BF_2 174.19 0.90 8426 270002439 EEZ98886.1 1242 5.3e-133 hypothetical protein TcasGA2_TC004501 [Tribolium castaneum] 642912470 XM_008202654.1 112 2.10956e-48 PREDICTED: Tribolium castaneum transcription elongation regulator 1 (LOC659146), transcript variant X2, mRNA K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 601 4.6e-60 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF00397//PF12905//PF08503//PF10018 WW domain//Endo-alpha-N-acetylgalactosaminidase//Tetrahydrodipicolinate succinyltransferase N-terminal//Vitamin-D-receptor interacting Mediator subunit 4 GO:0042967//GO:0006531//GO:0006522//GO:0006357 acyl-carrier-protein biosynthetic process//aspartate metabolic process//alanine metabolic process//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0033926//GO:0001104//GO:0047200 protein binding//glycopeptide alpha-N-acetylgalactosaminidase activity//RNA polymerase II transcription cofactor activity//tetrahydrodipicolinate N-acetyltransferase activity GO:0016592 mediator complex KOG0155 Transcription factor CA150 Cluster-8309.41029 BF_2 115.70 3.75 1577 270002439 EEZ98886.1 272 3.0e-21 hypothetical protein TcasGA2_TC004501 [Tribolium castaneum] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 135 9.3e-07 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862 DDHD domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.41030 BF_2 38.81 0.71 2563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05083 LST-1 protein GO:0000902//GO:0006955 cell morphogenesis//immune response -- -- GO:0016020 membrane -- -- Cluster-8309.41031 BF_2 103.83 0.39 11522 170038835 XP_001847253.1 1154 1.1e-122 calcium-activated potassium channel alpha chain [Culex quinquefasciatus]>gi|167862444|gb|EDS25827.1| calcium-activated potassium channel alpha chain [Culex quinquefasciatus] 642936834 XM_008199616.1 328 2.4371e-168 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X2, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1092 7.3e-117 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF00520//PF01478//PF03493//PF07503 Ion transport protein//Type IV leader peptidase family//Calcium-activated BK potassium channel alpha subunit//HypF finger GO:0006811//GO:0055085//GO:0006813 ion transport//transmembrane transport//potassium ion transport GO:0000166//GO:0008270//GO:0005216//GO:0005249//GO:0004190//GO:0060072//GO:0015269 nucleotide binding//zinc ion binding//ion channel activity//voltage-gated potassium channel activity//aspartic-type endopeptidase activity//large conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity GO:0016020//GO:0008076 membrane//voltage-gated potassium channel complex KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.41034 BF_2 1412.48 4.96 12204 270001010 EEZ97457.1 2072 4.3e-229 hypothetical protein TcasGA2_TC011288 [Tribolium castaneum] 662203988 XM_008477133.1 151 6.3927e-70 PREDICTED: Diaphorina citri calcium-activated potassium channel slowpoke-like (LOC103512372), mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1831 1.6e-202 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF00397//PF12905 WW domain//Endo-alpha-N-acetylgalactosaminidase -- -- GO:0005515//GO:0033926 protein binding//glycopeptide alpha-N-acetylgalactosaminidase activity -- -- KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.41035 BF_2 621.11 7.42 3790 478258223 ENN78352.1 1166 1.5e-124 hypothetical protein YQE_05154, partial [Dendroctonus ponderosae] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q28FD1 632 5.3e-64 Alcohol dehydrogenase [NADP(+)] OS=Xenopus tropicalis GN=akr1a1 PE=2 SV=1 PF04869 Uso1 / p115 like vesicle tethering protein, head region GO:0048280//GO:0006886 vesicle fusion with Golgi apparatus//intracellular protein transport -- -- GO:0000139//GO:0005737 Golgi membrane//cytoplasm KOG1577 Aldo/keto reductase family proteins Cluster-8309.41037 BF_2 654.93 23.03 1477 642917156 XP_008191141.1 1740 1.7e-191 PREDICTED: filamin-A [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 215 4.6e-16 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41038 BF_2 1258.29 12.05 4657 546681405 ERL91502.1 4308 0.0e+00 hypothetical protein D910_08832 [Dendroctonus ponderosae] 768409434 XM_011554491.1 152 6.75268e-71 PREDICTED: Plutella xylostella filamin-A-like (LOC105384276), mRNA K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q8BTM8 542 1.8e-53 Filamin-A OS=Mus musculus GN=Flna PE=1 SV=5 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.41039 BF_2 599.21 5.06 5245 642932814 XP_008196996.1 2812 0.0e+00 PREDICTED: protein CLEC16A isoform X4 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 1236 6.7e-134 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG2219 Uncharacterized conserved protein Cluster-8309.41042 BF_2 158.57 2.44 3001 641652894 XP_008178577.1 157 1.2e-07 PREDICTED: uncharacterized protein DDB_G0283697-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.41043 BF_2 122.18 0.97 5559 270012402 EFA08850.1 3240 0.0e+00 hypothetical protein TcasGA2_TC006551 [Tribolium castaneum] 642932661 XM_008198715.1 84 5.10396e-33 PREDICTED: Tribolium castaneum inactive rhomboid protein 1 (LOC658816), mRNA -- -- -- -- Q76NQ1 1377 3.2e-150 Inactive rhomboid protein 1 OS=Drosophila melanogaster GN=rho-5 PE=2 SV=1 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2290 Rhomboid family proteins Cluster-8309.41044 BF_2 3833.16 136.14 1465 478258513 ENN78588.1 1533 1.6e-167 hypothetical protein YQE_04955, partial [Dendroctonus ponderosae] 817195914 XM_012418095.1 263 4.12717e-133 PREDICTED: Orussus abietinus cAMP-dependent protein kinase type I regulatory subunit (LOC105695993), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P16905 1375 1.4e-150 cAMP-dependent protein kinase type I regulatory subunit OS=Drosophila melanogaster GN=Pka-R1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.41046 BF_2 376.70 11.56 1650 642928984 XP_008195645.1 1519 7.8e-166 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q6UWM7 1099 1.6e-118 Lactase-like protein OS=Homo sapiens GN=LCTL PE=1 SV=2 PF02226//PF00232 Picornavirus coat protein (VP4)//Glycosyl hydrolase family 1 GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0004553//GO:0016798//GO:0005198 hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity, acting on glycosyl bonds//structural molecule activity GO:0019028 viral capsid KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.41047 BF_2 39.74 0.73 2549 642912996 XP_008201344.1 703 5.0e-71 PREDICTED: synaptic vesicle glycoprotein 2C-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q9JIS5 276 6.7e-23 Synaptic vesicle glycoprotein 2A OS=Mus musculus GN=Sv2a PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.41048 BF_2 1028.96 3.43 12845 270007509 EFA03957.1 1887 1.3e-207 hypothetical protein TcasGA2_TC014101 [Tribolium castaneum] 332374221 BT127290.1 481 0 Dendroctonus ponderosae clone DPO022_A01 unknown mRNA K14943 MBNL muscleblind http://www.genome.jp/dbget-bin/www_bget?ko:K14943 O16011 733 3.5e-75 Protein muscleblind OS=Drosophila melanogaster GN=mbl PE=2 SV=2 PF03176//PF01522//PF01607//PF00642//PF02198 MMPL family//Polysaccharide deacetylase//Chitin binding Peritrophin-A domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Sterile alpha motif (SAM)/Pointed domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0043565//GO:0016810//GO:0008061//GO:0046872 sequence-specific DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding//metal ion binding GO:0005634//GO:0005576//GO:0016020 nucleus//extracellular region//membrane -- -- Cluster-8309.41049 BF_2 978.00 135.07 590 260794194 XP_002592094.1 158 1.8e-08 hypothetical protein BRAFLDRAFT_84963 [Branchiostoma floridae]>gi|229277309|gb|EEN48105.1| hypothetical protein BRAFLDRAFT_84963 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41052 BF_2 556.87 52.96 727 91085625 XP_966506.1 157 2.9e-08 PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|642927073|ref|XP_008195125.1| PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|642927076|ref|XP_008195126.1| PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06652 Methuselah N-terminus GO:0007186//GO:0006950 G-protein coupled receptor signaling pathway//response to stress GO:0004930 G-protein coupled receptor activity -- -- -- -- Cluster-8309.41053 BF_2 255.43 1.99 5665 642927078 XP_008195127.1 1305 1.7e-140 PREDICTED: probable G-protein coupled receptor Mth-like 5 [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VGG8 922 1.9e-97 Probable G-protein coupled receptor Mth-like 5 OS=Drosophila melanogaster GN=mthl5 PE=2 SV=2 PF00001//PF02742//PF00002 7 transmembrane receptor (rhodopsin family)//Iron dependent repressor, metal binding and dimerisation domain//7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0046914//GO:0046983 G-protein coupled receptor activity//transition metal ion binding//protein dimerization activity GO:0016021 integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.41054 BF_2 768.47 261.75 409 821003176 XP_012365190.1 667 1.2e-67 PREDICTED: polyubiquitin-C isoform X4 [Nomascus leucogenys] 56199551 AY752852.1 183 3.2176e-89 Culicoides sonorensis clone CsUB1 ubiquitin mRNA, complete cds K08770 UBC ubiquitin C http://www.genome.jp/dbget-bin/www_bget?ko:K08770 Q63429 667 5.0e-69 Polyubiquitin-C OS=Rattus norvegicus GN=Ubc PE=1 SV=1 PF04452//PF00240//PF14560 RNA methyltransferase//Ubiquitin family//Ubiquitin-like domain GO:0006364 rRNA processing GO:0005515//GO:0008168 protein binding//methyltransferase activity -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.41057 BF_2 170.24 1.57 4829 546672885 ERL84608.1 3593 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1470 4.5e-161 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF08545//PF00108//PF00107 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain//Zinc-binding dehydrogenase GO:0008152//GO:0006633//GO:0042967//GO:0055114 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process//oxidation-reduction process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.41059 BF_2 326.72 6.84 2284 642911463 XP_008199434.1 611 2.1e-60 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06872 EspG protein GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.4106 BF_2 13.00 0.34 1901 642923176 XP_008193641.1 192 6.7e-12 PREDICTED: kinesin-like protein subito isoform X2 [Tribolium castaneum] -- -- -- -- -- K10402 KIF20 kinesin family member 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10402 Q80WE4 138 5.1e-07 Kinesin-like protein KIF20B OS=Mus musculus GN=Kif20b PE=1 SV=3 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.41065 BF_2 483.30 3.62 5878 270004589 EFA01037.1 1102 6.3e-117 hypothetical protein TcasGA2_TC003953 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U3I9 177 4.7e-11 Zinc finger protein 865 OS=Mus musculus GN=Znf865 PE=2 SV=1 PF01420//PF13465//PF01544//PF00096//PF00688//PF13912//PF09668 Type I restriction modification DNA specificity domain//Zinc-finger double domain//CorA-like Mg2+ transporter protein//Zinc finger, C2H2 type//TGF-beta propeptide//C2H2-type zinc finger//Aspartyl protease GO:0040007//GO:0030001//GO:0007165//GO:0055085//GO:0008283//GO:0006508//GO:0006304 growth//metal ion transport//signal transduction//transmembrane transport//cell proliferation//proteolysis//DNA modification GO:0008083//GO:0004190//GO:0003677//GO:0046873//GO:0046872 growth factor activity//aspartic-type endopeptidase activity//DNA binding//metal ion transmembrane transporter activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.41067 BF_2 1234.47 7.17 7490 478256535 ENN76719.1 1038 2.1e-109 hypothetical protein YQE_06784, partial [Dendroctonus ponderosae] 683942502 XM_009101103.1 36 3.31879e-06 PREDICTED: Serinus canaria zinc finger protein 329-like (LOC103825865), partial mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 629 2.3e-63 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF07975//PF12142//PF13465//PF16622//PF05191//PF01428//PF13912//PF04810//PF00130//PF01155//PF06397//PF00096//PF07776//PF04889 TFIIH C1-like domain//Polyphenol oxidase middle domain//Zinc-finger double domain//zinc-finger C2H2-type//Adenylate kinase, active site lid//AN1-like Zinc finger//C2H2-type zinc finger//Sec23/Sec24 zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Desulfoferrodoxin, N-terminal domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Cwf15/Cwc15 cell cycle control protein GO:0046034//GO:0006570//GO:0006281//GO:0006886//GO:0006464//GO:0055114//GO:0035556//GO:0000398//GO:0006118//GO:0006144//GO:0006888 ATP metabolic process//tyrosine metabolic process//DNA repair//intracellular protein transport//cellular protein modification process//oxidation-reduction process//intracellular signal transduction//mRNA splicing, via spliceosome//obsolete electron transport//purine nucleobase metabolic process//ER to Golgi vesicle-mediated transport GO:0004097//GO:0005506//GO:0004017//GO:0008270//GO:0016151//GO:0046872 catechol oxidase activity//iron ion binding//adenylate kinase activity//zinc ion binding//nickel cation binding//metal ion binding GO:0030127//GO:0005681//GO:0005634 COPII vesicle coat//spliceosomal complex//nucleus -- -- Cluster-8309.41068 BF_2 20.70 0.36 2682 825706152 NP_081979.1 186 4.7e-11 zinc finger protein 626 [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 B7Z6K7 169 1.8e-10 Putative uncharacterized zinc finger protein 814 OS=Homo sapiens GN=ZNF814 PE=2 SV=2 PF00096//PF13465//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.41072 BF_2 48.15 0.31 6786 91076704 XP_972106.1 1365 2.3e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 7.2e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF01297//PF00175//PF00892//PF13371//PF08449//PF08030//PF04142//PF10147 Zinc-uptake complex component A periplasmic//Oxidoreductase NAD-binding domain//EamA-like transporter family//Tetratricopeptide repeat//UAA transporter family//Ferric reductase NAD binding domain//Nucleotide-sugar transporter//Growth arrest and DNA-damage-inducible proteins-interacting protein 1 GO:0030001//GO:0055085//GO:0007049//GO:0015780//GO:0055114//GO:0008643 metal ion transport//transmembrane transport//cell cycle//nucleotide-sugar transport//oxidation-reduction process//carbohydrate transport GO:0016491//GO:0005515//GO:0005351//GO:0005338//GO:0046872 oxidoreductase activity//protein binding//sugar:proton symporter activity//nucleotide-sugar transmembrane transporter activity//metal ion binding GO:0005634//GO:0016021//GO:0000139//GO:0016020 nucleus//integral component of membrane//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.41073 BF_2 485.46 12.50 1912 86515328 NP_001034489.1 2277 1.2e-253 homothorax [Tribolium castaneum]>gi|38490517|emb|CAD57735.1| homothorax [Tribolium castaneum]>gi|270010957|gb|EFA07405.1| hypothetical protein TcasGA2_TC008629 [Tribolium castaneum] 86515327 NM_001039400.1 899 0 Tribolium castaneum homothorax (Hth), mRNA >gnl|BL_ORD_ID|1176366 Tribolium castaneum mRNA for homothorax (hth gene) K16672 HTH homeobox protein homothorax http://www.genome.jp/dbget-bin/www_bget?ko:K16672 O46339 1697 8.5e-188 Homeobox protein homothorax OS=Drosophila melanogaster GN=hth PE=1 SV=1 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0773 Transcription factor MEIS1 and related HOX domain proteins Cluster-8309.41074 BF_2 2.00 0.45 473 -- -- -- -- -- 642934619 XM_970761.2 106 2.39806e-46 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41075 BF_2 403.71 1.60 10826 91090089 XP_975854.1 857 3.0e-88 PREDICTED: protein Tob1 [Tribolium castaneum]>gi|270013495|gb|EFA09943.1| hypothetical protein TcasGA2_TC012096 [Tribolium castaneum] 642934619 XM_970761.2 381 0 PREDICTED: Tribolium castaneum protein Tob1 (LOC659063), mRNA K14443 TOB protein Tob/BTG http://www.genome.jp/dbget-bin/www_bget?ko:K14443 Q8R5K6 502 1.8e-48 Protein Tob1 OS=Rattus norvegicus GN=Tob1 PE=2 SV=1 PF10766 Multidrug efflux pump-associated protein AcrZ GO:0006855//GO:0015893 drug transmembrane transport//drug transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.41076 BF_2 3127.68 61.37 2419 91088273 XP_967838.1 599 5.5e-59 PREDICTED: protein scylla [Tribolium castaneum]>gi|270012158|gb|EFA08606.1| hypothetical protein TcasGA2_TC006266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTH4 305 2.8e-26 Protein scylla OS=Drosophila melanogaster GN=scyl PE=2 SV=1 PF07809 RTP801 C-terminal region GO:0009968 negative regulation of signal transduction -- -- GO:0005737 cytoplasm -- -- Cluster-8309.41077 BF_2 102.00 0.59 7571 642930787 XP_008196091.1 3466 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.8e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF02217//PF16711//PF01428//PF00383//PF02144//PF08069//PF08211 Origin of replication binding protein//Actin-binding domain of plant-specific actin-binding protein//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region//Repair protein Rad1/Rec1/Rad17//Ribosomal S13/S15 N-terminal domain//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0006281//GO:0042254//GO:0046087//GO:0006260//GO:0006412//GO:0006807//GO:0009972//GO:0006206 DNA repair//ribosome biogenesis//cytidine metabolic process//DNA replication//translation//nitrogen compound metabolic process//cytidine deamination//pyrimidine nucleobase metabolic process GO:0003779//GO:0003688//GO:0003735//GO:0008270//GO:0004126 actin binding//DNA replication origin binding//structural constituent of ribosome//zinc ion binding//cytidine deaminase activity GO:0005840//GO:0005634//GO:0046809 ribosome//nucleus//replication compartment KOG3183 Predicted Zn-finger protein Cluster-8309.41080 BF_2 375.01 3.25 5113 189237669 XP_967427.2 2257 6.4e-251 PREDICTED: hypoxia-inducible factor 1-alpha [Tribolium castaneum] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 Q24167 843 2.4e-88 Protein similar OS=Drosophila melanogaster GN=sima PE=1 SV=2 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3558 Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 Cluster-8309.41081 BF_2 499.58 2.89 7506 91091506 XP_969096.1 3513 0.0e+00 PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|642936851|ref|XP_008197901.1| PREDICTED: ubiquitin-protein ligase E3A [Tribolium castaneum]>gi|270000934|gb|EEZ97381.1| hypothetical protein TcasGA2_TC011206 [Tribolium castaneum] 170030268 XM_001842960.1 189 2.94903e-91 Culex quinquefasciatus ubiquitin-protein ligase E3A, mRNA K10587 UBE3A, E6AP ubiquitin-protein ligase E3 A http://www.genome.jp/dbget-bin/www_bget?ko:K10587 Q05086 2156 2.0e-240 Ubiquitin-protein ligase E3A OS=Homo sapiens GN=UBE3A PE=1 SV=4 PF00632//PF00895//PF15798 HECT-domain (ubiquitin-transferase)//ATP synthase protein 8//Proline-rich AKT1 substrate 1 GO:0016567//GO:0048011//GO:0015992//GO:0015986//GO:0032007 protein ubiquitination//neurotrophin TRK receptor signaling pathway//proton transport//ATP synthesis coupled proton transport//negative regulation of TOR signaling GO:0004842//GO:0015078 ubiquitin-protein transferase activity//hydrogen ion transmembrane transporter activity GO:0005622//GO:0000276 intracellular//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG0941 E3 ubiquitin protein ligase Cluster-8309.41083 BF_2 243.31 1.96 5490 546675155 ERL86391.1 1436 1.1e-155 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 989 3.1e-105 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF05944//PF14863//PF02384//PF13181//PF01555//PF13371//PF00515//PF13414//PF14721//PF02086 Phage small terminase subunit//Alkyl sulfatase dimerisation//N-6 DNA Methylase//Tetratricopeptide repeat//DNA methylase//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term//D12 class N6 adenine-specific DNA methyltransferase GO:0032775//GO:0019069//GO:0006306 DNA methylation on adenine//viral capsid assembly//DNA methylation GO:0046983//GO:0005515//GO:0004519//GO:0003677//GO:0009007//GO:0008170 protein dimerization activity//protein binding//endonuclease activity//DNA binding//site-specific DNA-methyltransferase (adenine-specific) activity//N-methyltransferase activity -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.41084 BF_2 1726.89 15.42 4972 332375504 AEE62893.1 1136 6.1e-121 unknown [Dendroctonus ponderosae] 573887517 XM_006631469.1 44 7.85208e-11 PREDICTED: Lepisosteus oculatus axonemal dynein light intermediate polypeptide 1-like (LOC102695726), mRNA K10410 DNALI dynein light intermediate chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10410 Q26630 486 5.9e-47 33 kDa inner dynein arm light chain, axonemal OS=Strongylocentrotus purpuratus PE=1 SV=1 PF12474//PF15898//PF02183//PF07850//PF04111//PF01166 Polo kinase kinase//cGMP-dependent protein kinase interacting domain//Homeobox associated leucine zipper//Renin receptor-like protein//Autophagy protein Apg6//TSC-22/dip/bun family GO:0007165//GO:0016310//GO:0009069//GO:0006914//GO:0006355 signal transduction//phosphorylation//serine family amino acid metabolic process//autophagy//regulation of transcription, DNA-templated GO:0004872//GO:0019901//GO:0043565//GO:0004674//GO:0003700 receptor activity//protein kinase binding//sequence-specific DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG4001 Axonemal dynein light chain Cluster-8309.41088 BF_2 169.94 0.95 7752 642930787 XP_008196091.1 3584 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.8e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF08069//PF01428//PF07531//PF02217//PF16711 Ribosomal S13/S15 N-terminal domain//AN1-like Zinc finger//NHR1 homology to TAF//Origin of replication binding protein//Actin-binding domain of plant-specific actin-binding protein GO:0006412//GO:0042254//GO:0006355//GO:0006260 translation//ribosome biogenesis//regulation of transcription, DNA-templated//DNA replication GO:0003779//GO:0003688//GO:0003700//GO:0008270//GO:0003735 actin binding//DNA replication origin binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//structural constituent of ribosome GO:0005667//GO:0046809//GO:0005840 transcription factor complex//replication compartment//ribosome KOG3183 Predicted Zn-finger protein Cluster-8309.41089 BF_2 575.36 5.90 4370 642910688 XP_008200061.1 1707 3.3e-187 PREDICTED: LOW QUALITY PROTEIN: probable palmitoyltransferase ZDHHC16 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q969W1 740 1.8e-76 Probable palmitoyltransferase ZDHHC16 OS=Homo sapiens GN=ZDHHC16 PE=2 SV=1 PF01529//PF00089 DHHC palmitoyltransferase//Trypsin GO:0006508 proteolysis GO:0008270//GO:0004252 zinc ion binding//serine-type endopeptidase activity -- -- -- -- Cluster-8309.41091 BF_2 79.83 0.75 4725 189242201 XP_972508.2 887 4.3e-92 PREDICTED: protein suppressor of white apricot, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12297 432 1.0e-40 Protein suppressor of white apricot OS=Drosophila melanogaster GN=su(w[a]) PE=1 SV=3 PF04277//PF01805//PF07127 Oxaloacetate decarboxylase, gamma chain//Surp module//Late nodulin protein GO:0006525//GO:0006560//GO:0006814//GO:0071436//GO:0009878//GO:0006090//GO:0006396 arginine metabolic process//proline metabolic process//sodium ion transport//sodium ion export//nodule morphogenesis//pyruvate metabolic process//RNA processing GO:0003723//GO:0008948//GO:0015081//GO:0046872 RNA binding//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity//metal ion binding GO:0016020 membrane KOG1847 mRNA splicing factor Cluster-8309.41093 BF_2 1599.82 71.28 1226 91087587 XP_971919.1 1021 3.2e-108 PREDICTED: ras-related protein Rab-2 [Tribolium castaneum]>gi|270010699|gb|EFA07147.1| hypothetical protein TcasGA2_TC010138 [Tribolium castaneum] 768435213 XM_011560742.1 215 1.65684e-106 PREDICTED: Plutella xylostella ras-related protein Rab-2A (LOC105389599), mRNA K07877 RAB2A Ras-related protein Rab-2A http://www.genome.jp/dbget-bin/www_bget?ko:K07877 Q05975 976 2.2e-104 Ras-related protein Rab-2 OS=Lymnaea stagnalis GN=RAB2 PE=2 SV=1 PF03193//PF08477//PF01926//PF00071//PF04670//PF00025 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.41095 BF_2 4650.26 81.64 2670 332375592 AEE62937.1 1523 4.3e-166 unknown [Dendroctonus ponderosae]>gi|478256607|gb|ENN76789.1| hypothetical protein YQE_06630, partial [Dendroctonus ponderosae]>gi|546685197|gb|ERL94724.1| hypothetical protein D910_11998 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.41096 BF_2 1703.47 18.36 4169 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41098 BF_2 1069.48 9.42 5034 859132801 AKO63316.1 1700 2.4e-186 acetyl CoA acetyltransferase [Leptinotarsa decemlineata] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 1338 9.5e-146 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF14634//PF00108//PF02803 zinc-RING finger domain//Thiolase, N-terminal domain//Thiolase, C-terminal domain GO:0008152 metabolic process GO:0005515//GO:0016747//GO:0008270 protein binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.41099 BF_2 509.66 3.04 7307 572308871 XP_006620242.1 1074 1.4e-113 PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X1 [Apis dorsata]>gi|572308873|ref|XP_006620243.1| PREDICTED: ribose-phosphate pyrophosphokinase 2-like isoform X2 [Apis dorsata] 837814424 XM_012928152.1 259 3.50886e-130 PREDICTED: Ochotona princeps ribose-phosphate pyrophosphokinase 1 (LOC101518950), mRNA K00948 PRPS, prsA ribose-phosphate pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00948 Q2HJ58 1002 1.3e-106 Ribose-phosphate pyrophosphokinase 1 OS=Bos taurus GN=PRPS1 PE=2 SV=3 PF00156//PF00160//PF14572 Phosphoribosyl transferase domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Phosphoribosyl synthetase-associated domain GO:0000413//GO:0009116//GO:0009165//GO:0006144//GO:0006457//GO:0006098 protein peptidyl-prolyl isomerization//nucleoside metabolic process//nucleotide biosynthetic process//purine nucleobase metabolic process//protein folding//pentose-phosphate shunt GO:0000287//GO:0004749//GO:0003755 magnesium ion binding//ribose phosphate diphosphokinase activity//peptidyl-prolyl cis-trans isomerase activity -- -- KOG1448 Ribose-phosphate pyrophosphokinase Cluster-8309.41102 BF_2 821.91 10.08 3697 642935566 XP_008198061.1 3825 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F isoform X1 [Tribolium castaneum] 642935565 XM_008199839.1 1084 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X1, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 2398 8.5e-269 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.41103 BF_2 273.23 3.40 3646 642935570 XP_008198063.1 3792 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F isoform X3 [Tribolium castaneum] 642935569 XM_008199841.1 1108 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X3, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 P12252 2413 1.5e-270 cAMP-specific 3',5'-cyclic phosphodiesterase OS=Drosophila melanogaster GN=dnc PE=1 SV=4 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.41105 BF_2 91.84 2.07 2142 646682520 KDR02319.1 1568 2.1e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.48417e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.0e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00069//PF07714//PF00937 Protein kinase domain//Protein tyrosine kinase//Coronavirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.41106 BF_2 375.33 6.94 2550 91082351 XP_967256.1 613 1.4e-60 PREDICTED: probable uridine nucleosidase 1 [Tribolium castaneum]>gi|270007493|gb|EFA03941.1| hypothetical protein TcasGA2_TC014082 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P6J4 247 1.6e-19 Uncharacterized protein C1683.06c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC1683.06c PE=3 SV=1 PF06156//PF01105//PF05964//PF02212//PF01496 Protein of unknown function (DUF972)//emp24/gp25L/p24 family/GOLD//F/Y-rich N-terminus//Dynamin GTPase effector domain//V-type ATPase 116kDa subunit family GO:0015992//GO:0006260//GO:0006810//GO:0015991 proton transport//DNA replication//transport//ATP hydrolysis coupled proton transport GO:0005525//GO:0015078//GO:0003924 GTP binding//hydrogen ion transmembrane transporter activity//GTPase activity GO:0033179//GO:0016021//GO:0005634 proton-transporting V-type ATPase, V0 domain//integral component of membrane//nucleus KOG2938 Predicted inosine-uridine preferring nucleoside hydrolase Cluster-8309.41111 BF_2 252.76 1.10 9892 478255274 ENN75503.1 1875 2.5e-206 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] 815822303 XM_012377001.1 72 4.26595e-26 PREDICTED: Linepithema humile DNA primase small subunit (LOC105678028), mRNA K02684 PRI1 DNA primase small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02684 Q24317 1060 3.2e-113 DNA primase small subunit OS=Drosophila melanogaster GN=DNApol-alpha50 PE=2 SV=2 PF00884//PF13180//PF00057//PF00595//PF01896 Sulfatase//PDZ domain//Low-density lipoprotein receptor domain class A//PDZ domain (Also known as DHR or GLGF)//Eukaryotic and archaeal DNA primase small subunit GO:0008152//GO:0006351//GO:0006269 metabolic process//transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0005515//GO:0003896//GO:0008484 protein binding//DNA primase activity//sulfuric ester hydrolase activity GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.41112 BF_2 268.00 3.84 3203 642913576 XP_008201070.1 1499 3.2e-163 PREDICTED: delta(14)-sterol reductase-like [Tribolium castaneum]>gi|270001705|gb|EEZ98152.1| hypothetical protein TcasGA2_TC000578 [Tribolium castaneum] -- -- -- -- -- K19532 LBR lamin-B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K19532 O08984 572 4.0e-57 Lamin-B receptor OS=Rattus norvegicus GN=Lbr PE=1 SV=1 PF04140//PF01222 Isoprenylcysteine carboxyl methyltransferase (ICMT) family//Ergosterol biosynthesis ERG4/ERG24 family GO:0006479//GO:0006481 protein methylation//C-terminal protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1435 Sterol reductase/lamin B receptor Cluster-8309.41114 BF_2 1071.00 6.90 6783 642911668 XP_008200693.1 4171 0.0e+00 PREDICTED: chondroitin sulfate proteoglycan 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UVK1 1054 1.1e-112 Chondroitin sulfate proteoglycan 4 OS=Homo sapiens GN=CSPG4 PE=1 SV=2 PF00008//PF01024//PF15880 EGF-like domain//Colicin pore forming domain//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial GO:0019835//GO:0050829 cytolysis//defense response to Gram-negative bacterium GO:0005515 protein binding GO:0016021//GO:0005747//GO:0005739 integral component of membrane//mitochondrial respiratory chain complex I//mitochondrion KOG3597 Proteoglycan Cluster-8309.41116 BF_2 436.28 1.66 11251 642925080 XP_008194161.1 4665 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A1 [Tribolium castaneum] 573902448 XM_006638886.1 156 9.78986e-73 PREDICTED: Lepisosteus oculatus lysine-specific demethylase 6A-like (LOC102692642), transcript variant X4, mRNA K14950 ATP13A1 cation-transporting ATPase 13A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14950 Q9HD20 3312 0.0e+00 Manganese-transporting ATPase 13A1 OS=Homo sapiens GN=ATP13A1 PE=1 SV=2 PF02388//PF13414//PF00515//PF00782//PF03938//PF00122//PF13949//PF00102//PF13181//PF08797 FemAB family//TPR repeat//Tetratricopeptide repeat//Dual specificity phosphatase, catalytic domain//Outer membrane protein (OmpH-like)//E1-E2 ATPase//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//Tetratricopeptide repeat//HIRAN domain GO:0006570//GO:0006470//GO:0009252 tyrosine metabolic process//protein dephosphorylation//peptidoglycan biosynthetic process GO:0004725//GO:0008138//GO:0005515//GO:0016755//GO:0046872//GO:0016818//GO:0003676//GO:0051082//GO:0008270//GO:0000166 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//transferase activity, transferring amino-acyl groups//metal ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//unfolded protein binding//zinc ion binding//nucleotide binding -- -- KOG0209 P-type ATPase Cluster-8309.41118 BF_2 59.49 0.37 7100 642935775 XP_008198168.1 1750 5.5e-192 PREDICTED: integrin alpha-PS3-like [Tribolium castaneum] -- -- -- -- -- K17595 SPATA2 spermatogenesis-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17595 O44386 660 5.6e-67 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 PF00641//PF08516 Zn-finger in Ran binding protein and others//ADAM cysteine-rich GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.41119 BF_2 455.20 17.78 1358 332374922 AEE62602.1 939 1.2e-98 unknown [Dendroctonus ponderosae]>gi|478263079|gb|ENN81479.1| hypothetical protein YQE_02171, partial [Dendroctonus ponderosae]>gi|546682121|gb|ERL92102.1| hypothetical protein D910_09423 [Dendroctonus ponderosae] -- -- -- -- -- K09562 HSPBP1 hsp70-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K09562 Q99P31 320 2.8e-28 Hsp70-binding protein 1 OS=Mus musculus GN=Hspbp1 PE=2 SV=1 PF01602//PF00514//PF02985 Adaptin N terminal region//Armadillo/beta-catenin-like repeat//HEAT repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0030117 membrane coat KOG2160 Armadillo/beta-catenin-like repeat-containing protein Cluster-8309.41125 BF_2 1988.91 11.72 7385 642918353 XP_008199964.1 4772 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- K08018 RAPGEF2, PDZGEF1 Rap guanine nucleotide exchange factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08018 F1PBJ0 2374 1.0e-265 Rap guanine nucleotide exchange factor 2 OS=Canis familiaris GN=RAPGEF2 PE=1 SV=2 PF13180//PF00617//PF00595//PF00788 PDZ domain//RasGEF domain//PDZ domain (Also known as DHR or GLGF)//Ras association (RalGDS/AF-6) domain GO:0043087//GO:0007165//GO:0007264 regulation of GTPase activity//signal transduction//small GTPase mediated signal transduction GO:0005085//GO:0005515 guanyl-nucleotide exchange factor activity//protein binding -- -- KOG3542 cAMP-regulated guanine nucleotide exchange factor Cluster-8309.41126 BF_2 87.00 0.56 6766 642930106 XP_008196254.1 2042 7.2e-226 PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum]>gi|642930108|ref|XP_008196255.1| PREDICTED: probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial [Tribolium castaneum] 686207191 AP014521.1 40 1.79065e-08 Candidatus Tachikawaea gelatinosa DNA, complete genome K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q96HY7 1558 4.0e-171 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Homo sapiens GN=DHTKD1 PE=1 SV=2 PF09412//PF00676 Endoribonuclease XendoU//Dehydrogenase E1 component GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.41127 BF_2 3144.08 64.73 2319 270003863 EFA00311.1 1778 1.0e-195 hypothetical protein TcasGA2_TC003147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41129 BF_2 1417.92 10.43 5972 642924318 XP_008194246.1 2380 4.1e-265 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 1111 2.4e-119 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 PF05971//PF02714//PF12822//PF01504 Protein of unknown function (DUF890)//Calcium-dependent channel, 7TM region, putative phosphate//Protein of unknown function (DUF3816)//Phosphatidylinositol-4-phosphate 5-Kinase GO:0006821//GO:0006810//GO:0046488//GO:0006820 chloride transport//transport//phosphatidylinositol metabolic process//anion transport GO:0005215//GO:0005254//GO:0008168//GO:0016307 transporter activity//chloride channel activity//methyltransferase activity//phosphatidylinositol phosphate kinase activity GO:0016020//GO:0034707 membrane//chloride channel complex KOG2514 Uncharacterized conserved protein Cluster-8309.41131 BF_2 61.95 1.44 2084 642923254 XP_008193679.1 749 1.9e-76 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.2e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF03796//PF00154 DnaB-like helicase C terminal domain//recA bacterial DNA recombination protein GO:0006281//GO:0009432//GO:0006260 DNA repair//SOS response//DNA replication GO:0003697//GO:0005524//GO:0003678 single-stranded DNA binding//ATP binding//DNA helicase activity GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.41134 BF_2 414.01 2.28 7898 91093216 XP_966931.1 11506 0.0e+00 PREDICTED: pre-mRNA-processing-splicing factor 8 [Tribolium castaneum]>gi|270016589|gb|EFA13035.1| hypothetical protein TcasGA2_TC010565 [Tribolium castaneum] 642938178 XM_961838.2 2460 0 PREDICTED: Tribolium castaneum pre-mRNA-processing-splicing factor 8 (LOC655310), mRNA K12856 PRPF8, PRP8 pre-mRNA-processing factor 8 http://www.genome.jp/dbget-bin/www_bget?ko:K12856 Q6P2Q9 10945 0.0e+00 Pre-mRNA-processing-splicing factor 8 OS=Homo sapiens GN=PRPF8 PE=1 SV=2 PF08083//PF10147//PF10596//PF10597//PF03153//PF10598//PF08082//PF01398 PROCN (NUC071) domain//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//U6-snRNA interacting domain of PrP8//U5-snRNA binding site 2 of PrP8//Transcription factor IIA, alpha/beta subunit//RNA recognition motif of the spliceosomal PrP8//PRO8NT (NUC069), PrP8 N-terminal domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0000398//GO:0006367//GO:0007049 mRNA splicing, via spliceosome//transcription initiation from RNA polymerase II promoter//cell cycle GO:0003723//GO:0005515//GO:0017070//GO:0030623 RNA binding//protein binding//U6 snRNA binding//U5 snRNA binding GO:0005634//GO:0005681//GO:0005672 nucleus//spliceosomal complex//transcription factor TFIIA complex KOG1795 U5 snRNP spliceosome subunit Cluster-8309.41135 BF_2 403.92 5.96 3120 646712642 KDR17338.1 385 4.6e-34 Protein takeout [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O76879 228 3.0e-17 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 PF00129 Class I Histocompatibility antigen, domains alpha 1 and 2 GO:0006955 immune response -- -- -- -- -- -- Cluster-8309.41138 BF_2 202.35 3.45 2744 642931607 XP_008196654.1 4104 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 756 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 2955 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02171//PF02170//PF04810 Piwi domain//PAZ domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003676//GO:0008270 protein binding//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.41139 BF_2 1040.36 8.25 5565 642931607 XP_008196654.1 4512 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 826 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3322 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02171//PF02170//PF04810 Piwi domain//PAZ domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003676//GO:0008270 protein binding//nucleic acid binding//zinc ion binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.41140 BF_2 392.40 5.41 3323 642911714 XP_008200711.1 876 5.7e-91 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 704 2.1e-72 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0050662//GO:0003824//GO:0016491 coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.41141 BF_2 236.34 2.57 4135 642931115 XP_008201667.1 431 2.8e-39 PREDICTED: autism susceptibility gene 2 protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04617//PF08597 Hox9 activation region//Translation initiation factor eIF3 subunit GO:0006446//GO:0006351 regulation of translational initiation//transcription, DNA-templated GO:0003743 translation initiation factor activity GO:0005737//GO:0005852//GO:0005840//GO:0005634 cytoplasm//eukaryotic translation initiation factor 3 complex//ribosome//nucleus -- -- Cluster-8309.41142 BF_2 298.85 2.08 6302 91090504 XP_975968.1 873 2.4e-90 PREDICTED: ribonuclease Oy [Tribolium castaneum]>gi|270013355|gb|EFA09803.1| hypothetical protein TcasGA2_TC011946 [Tribolium castaneum] -- -- -- -- -- K01166 E3.1.27.1 ribonuclease T2 http://www.genome.jp/dbget-bin/www_bget?ko:K01166 Q7M456 400 7.0e-37 Ribonuclease Oy OS=Crassostrea gigas PE=1 SV=1 PF00445 Ribonuclease T2 family -- -- GO:0003723//GO:0033897 RNA binding//ribonuclease T2 activity -- -- KOG1642 Ribonuclease, T2 family Cluster-8309.41144 BF_2 187.69 2.19 3880 642920179 XP_008192235.1 372 1.8e-32 PREDICTED: uncharacterized protein LOC103312687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04976 DMSO reductase anchor subunit (DmsC) GO:0019645 anaerobic electron transport chain -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41145 BF_2 1590.52 23.70 3095 332376929 AEE63604.1 1043 2.3e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q05319 445 2.1e-42 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41146 BF_2 1860.42 4.02 19648 646716100 KDR19487.1 3053 0.0e+00 E3 ubiquitin-protein ligase MARCH6 [Zootermopsis nevadensis] 847042359 XM_012951711.1 93 1.79831e-37 PREDICTED: Jaculus jaculus membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase (March6), mRNA K10661 MARCH6, DOA10 E3 ubiquitin-protein ligase MARCH6 http://www.genome.jp/dbget-bin/www_bget?ko:K10661 O60337 1868 1.3e-206 E3 ubiquitin-protein ligase MARCH6 OS=Homo sapiens GN=MARCH6 PE=1 SV=2 PF12906//PF03165//PF00400//PF13639//PF00004 RING-variant domain//MH1 domain//WD domain, G-beta repeat//Ring finger domain//ATPase family associated with various cellular activities (AAA) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0005524//GO:0008270 protein binding//ATP binding//zinc ion binding GO:0005622 intracellular KOG1609 Protein involved in mRNA turnover and stability Cluster-8309.41147 BF_2 637.66 7.28 3953 642931208 XP_008196484.1 1228 1.0e-131 PREDICTED: WD repeat domain phosphoinositide-interacting protein 2 isoform X3 [Tribolium castaneum]>gi|270012114|gb|EFA08562.1| hypothetical protein TcasGA2_TC006217 [Tribolium castaneum] -- -- -- -- -- K17908 WIPI, ATG18 autophagy-related protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K17908 Q9Y4P8 862 1.2e-90 WD repeat domain phosphoinositide-interacting protein 2 OS=Homo sapiens GN=WIPI2 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2110 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.41148 BF_2 3543.52 39.86 4006 91094331 XP_966352.1 4668 0.0e+00 PREDICTED: ubiquitin-like modifier-activating enzyme 1 [Tribolium castaneum] 766942063 XM_011505379.1 303 6.65416e-155 PREDICTED: Ceratosolen solmsi marchali ubiquitin-like modifier-activating enzyme 1 (LOC105366815), mRNA K03178 UBE1, UBA1 ubiquitin-activating enzyme E1 http://www.genome.jp/dbget-bin/www_bget?ko:K03178 Q29504 3516 0.0e+00 Ubiquitin-like modifier-activating enzyme 1 OS=Oryctolagus cuniculus GN=UBA1 PE=2 SV=1 PF13241//PF00899//PF00070//PF01006 Putative NAD(P)-binding//ThiF family//Pyridine nucleotide-disulphide oxidoreductase//Hepatitis C virus non-structural protein NS4a GO:0016032//GO:0019354//GO:0006779//GO:0055114 viral process//siroheme biosynthetic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0043115//GO:0016491//GO:0008641 precorrin-2 dehydrogenase activity//oxidoreductase activity//small protein activating enzyme activity GO:0019012 virion KOG2012 Ubiquitin activating enzyme UBA1 Cluster-8309.41150 BF_2 46.13 1.11 2023 91091818 XP_966528.1 1068 1.9e-113 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 714 8.7e-74 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0005216//GO:0005234//GO:0004970 ion channel activity//extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.41152 BF_2 915.42 28.29 1641 91088249 XP_966392.1 2026 1.3e-224 PREDICTED: myosin-IA [Tribolium castaneum]>gi|270011817|gb|EFA08265.1| hypothetical protein TcasGA2_TC005895 [Tribolium castaneum] 755988894 XM_011313704.1 50 1.18062e-14 PREDICTED: Fopius arisanus myosin-IA (LOC105271894), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 1435 1.8e-157 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF06017//PF00612//PF00063 Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Myosin head (motor domain) -- -- GO:0003774//GO:0005524//GO:0005515 motor activity//ATP binding//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.41155 BF_2 3521.11 34.91 4507 546679118 ERL89623.1 1551 4.2e-169 hypothetical protein D910_06988 [Dendroctonus ponderosae] 195146567 XM_002014220.1 155 1.40428e-72 Drosophila persimilis gpdh (Dper\Gpdh), mRNA K00006 GPD1 glycerol-3-phosphate dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00006 O97463 1392 4.7e-152 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic OS=Drosophila kanekoi GN=Gpdh1 PE=3 SV=3 PF01210//PF03523//PF12153//PF07479 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Macrophage scavenger receptor//LPS binding domain of CAP18 (C terminal)//NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus GO:0046168//GO:0042742//GO:0006898//GO:0006072//GO:0007165//GO:0046486//GO:0005975//GO:0055114 glycerol-3-phosphate catabolic process//defense response to bacterium//receptor-mediated endocytosis//glycerol-3-phosphate metabolic process//signal transduction//glycerolipid metabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0005044//GO:0016616//GO:0051287//GO:0004367 scavenger receptor activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//glycerol-3-phosphate dehydrogenase [NAD+] activity GO:0016020//GO:0009331 membrane//glycerol-3-phosphate dehydrogenase complex KOG2711 Glycerol-3-phosphate dehydrogenase/dihydroxyacetone 3-phosphate reductase Cluster-8309.41156 BF_2 359.66 1.84 8443 546680590 ERL90833.1 6072 0.0e+00 hypothetical protein D910_08178 [Dendroctonus ponderosae] 642925848 XM_008192328.1 61 4.74039e-20 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- Q6DFF9 2154 3.8e-240 Mitogen-activated protein kinase-binding protein 1 OS=Xenopus laevis GN=mapkbp1 PE=2 SV=1 PF08367//PF00400 Peptidase M16C associated//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG1408 WD40 repeat protein Cluster-8309.41158 BF_2 279.53 8.44 1672 546684210 ERL93915.1 1470 3.8e-160 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 94 4.1778e-39 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1096 3.6e-118 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.41159 BF_2 70.00 0.52 5881 91076824 XP_967870.1 1208 3.2e-129 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 729 4.6e-75 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.41160 BF_2 245.50 4.51 2566 546685769 ERL95218.1 2378 3.0e-265 hypothetical protein D910_12485 [Dendroctonus ponderosae] 514694901 XM_004994965.1 65 8.53497e-23 Salpingoeca rosetta bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 O95340 2061 7.1e-230 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2 OS=Homo sapiens GN=PAPSS2 PE=1 SV=2 PF01293//PF01747//PF01583 Phosphoenolpyruvate carboxykinase//ATP-sulfurylase//Adenylylsulphate kinase GO:0006094//GO:0006099//GO:0015976//GO:0006790//GO:0006144//GO:0000103 gluconeogenesis//tricarboxylic acid cycle//carbon utilization//sulfur compound metabolic process//purine nucleobase metabolic process//sulfate assimilation GO:0004612//GO:0005524//GO:0004781//GO:0004020 phosphoenolpyruvate carboxykinase (ATP) activity//ATP binding//sulfate adenylyltransferase (ATP) activity//adenylylsulfate kinase activity -- -- KOG4238 Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase Cluster-8309.41161 BF_2 315.87 1.01 13413 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 81 5.74927e-31 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q924T7 884 1.1e-92 E3 ubiquitin-protein ligase RNF31 OS=Mus musculus GN=Rnf31 PE=1 SV=2 PF07975//PF05121//PF01426//PF13465//PF08273//PF02845//PF00412//PF00641//PF09182//PF13912//PF05495//PF00096//PF07776 TFIIH C1-like domain//Gas vesicle protein K//BAH domain//Zinc-finger double domain//Zinc-binding domain of primase-helicase//CUE domain//LIM domain//Zn-finger in Ran binding protein and others//Bacterial purine repressor, N-terminal//C2H2-type zinc finger//CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0006281//GO:0031412//GO:0006269//GO:0006355//GO:0006351 DNA repair//gas vesicle organization//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//transcription, DNA-templated GO:0003896//GO:0008270//GO:0003682//GO:0003677//GO:0004386//GO:0005515//GO:0046872 DNA primase activity//zinc ion binding//chromatin binding//DNA binding//helicase activity//protein binding//metal ion binding GO:0005730//GO:0005634//GO:0005657//GO:0000785 nucleolus//nucleus//replication fork//chromatin -- -- Cluster-8309.41162 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41163 BF_2 19.00 5.47 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41164 BF_2 123.67 0.65 8210 478250393 ENN70888.1 1875 2.0e-206 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] 815792597 XM_012361475.1 47 2.7936e-12 PREDICTED: Linepithema humile fatty acid synthase-like (LOC105668856), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 878 3.4e-92 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF05524//PF00108//PF00107//PF00975//PF00106 PEP-utilising enzyme, N-terminal//Thiolase, N-terminal domain//Zinc-binding dehydrogenase//Thioesterase domain//short chain dehydrogenase GO:0008152//GO:0009401//GO:0055114//GO:0009058 metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//oxidation-reduction process//biosynthetic process GO:0016788//GO:0016491//GO:0016747 hydrolase activity, acting on ester bonds//oxidoreductase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.41165 BF_2 35.50 0.66 2538 546680929 ERL91103.1 603 2.0e-59 hypothetical protein D910_08445 [Dendroctonus ponderosae] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P22756 409 2.5e-38 Glutamate receptor ionotropic, kainate 1 OS=Rattus norvegicus GN=Grik1 PE=1 SV=3 PF03509//PF05889//PF06859 Gap junction alpha-8 protein (Cx50)//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//Bicoid-interacting protein 3 (Bin3) GO:0007154 cell communication GO:0016740//GO:0008168 transferase activity//methyltransferase activity GO:0005922 connexon complex -- -- Cluster-8309.41166 BF_2 263.50 2.08 5598 91088115 XP_969791.1 1930 5.8e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.6e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF01105//PF02966//PF04851 DEAD/DEAH box helicase//emp24/gp25L/p24 family/GOLD//Mitosis protein DIM1//Type III restriction enzyme, res subunit GO:0000398//GO:0006810 mRNA splicing, via spliceosome//transport GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0008026 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//ATP-dependent helicase activity GO:0016021//GO:0005681 integral component of membrane//spliceosomal complex KOG0330 ATP-dependent RNA helicase Cluster-8309.41167 BF_2 236.01 1.60 6477 675379920 KFM72822.1 1258 5.6e-135 Transposable element P transposase, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07967//PF08558 THAP domain//C3HC zinc finger-like//Telomere repeat binding factor (TRF) -- -- GO:0003676//GO:0008270//GO:0042803//GO:0042162 nucleic acid binding//zinc ion binding//protein homodimerization activity//telomeric DNA binding GO:0005634 nucleus -- -- Cluster-8309.41170 BF_2 74.58 5.68 836 478252357 ENN72783.1 568 7.4e-56 hypothetical protein YQE_10588, partial [Dendroctonus ponderosae]>gi|546680689|gb|ERL90915.1| hypothetical protein D910_08259 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A4QNC6 277 1.7e-23 Protein FAM136A OS=Xenopus tropicalis GN=fam136a PE=2 SV=1 PF02970//PF07464 Tubulin binding cofactor A//Apolipophorin-III precursor (apoLp-III) GO:0007021//GO:0006869 tubulin complex assembly//lipid transport GO:0051082//GO:0008289//GO:0015631 unfolded protein binding//lipid binding//tubulin binding GO:0005576//GO:0045298 extracellular region//tubulin complex KOG3377 Uncharacterized conserved protein Cluster-8309.41173 BF_2 32.55 2.21 903 642936923 XP_970894.2 287 3.1e-23 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.41174 BF_2 305.03 1.53 8641 642937304 XP_008198778.1 1898 4.6e-209 PREDICTED: zinc finger SWIM domain-containing protein 8 [Tribolium castaneum] 194892748 XM_001977686.1 154 9.71651e-72 Drosophila erecta GG19197 (Dere\GG19197), mRNA -- -- -- -- A7E2V4 868 5.2e-91 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 PF02024 Leptin GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region KOG3615 Uncharacterized conserved protein Cluster-8309.41175 BF_2 3837.21 15.48 10659 91080713 XP_975329.1 4737 0.0e+00 PREDICTED: leucine-rich PPR motif-containing protein, mitochondrial [Tribolium castaneum]>gi|270005471|gb|EFA01919.1| hypothetical protein TcasGA2_TC007529 [Tribolium castaneum] -- -- -- -- -- K17964 LRPPRC leucine-rich PPR motif-containing protein, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K17964 P42704 1298 8.8e-141 Leucine-rich PPR motif-containing protein, mitochondrial OS=Homo sapiens GN=LRPPRC PE=1 SV=3 PF00014//PF00536//PF07647//PF09246//PF13181//PF13414//PF00637//PF00515 Kunitz/Bovine pancreatic trypsin inhibitor domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PHAT//Tetratricopeptide repeat//TPR repeat//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0006355//GO:0016192//GO:0006886 regulation of transcription, DNA-templated//vesicle-mediated transport//intracellular protein transport GO:0003723//GO:0004867//GO:0005515 RNA binding//serine-type endopeptidase inhibitor activity//protein binding -- -- KOG3539 Spondins, extracellular matrix proteins Cluster-8309.41176 BF_2 1141.86 19.41 2748 642918856 XP_008191616.1 1413 2.5e-153 PREDICTED: pericentriolar material 1 protein isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76329 140 4.3e-07 Interaptin OS=Dictyostelium discoideum GN=abpD PE=1 SV=1 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.41178 BF_2 336.60 1.63 8940 642936570 XP_008198490.1 5154 0.0e+00 PREDICTED: guanylate cyclase 32E isoform X2 [Tribolium castaneum] 642936569 XM_008200268.1 589 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X2, mRNA -- -- -- -- Q07553 1915 2.1e-212 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00558//PF07701//PF01073//PF15427//PF00056//PF00069//PF02866//PF00211//PF07714 Vpu protein//Heme NO binding associated//3-beta hydroxysteroid dehydrogenase/isomerase family//S100P-binding protein//lactate/malate dehydrogenase, NAD binding domain//Protein kinase domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase GO:0032801//GO:0006182//GO:0008210//GO:0006144//GO:0019076//GO:0006812//GO:0008207//GO:0035556//GO:0055114//GO:0006694//GO:0008209//GO:0009190//GO:0046039//GO:0006468 receptor catabolic process//cGMP biosynthetic process//estrogen metabolic process//purine nucleobase metabolic process//viral release from host cell//cation transport//C21-steroid hormone metabolic process//intracellular signal transduction//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//cyclic nucleotide biosynthetic process//GTP metabolic process//protein phosphorylation GO:0004672//GO:0016849//GO:0016491//GO:0004383//GO:0048306//GO:0003854//GO:0005524//GO:0005261//GO:0016616 protein kinase activity//phosphorus-oxygen lyase activity//oxidoreductase activity//guanylate cyclase activity//calcium-dependent protein binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//ATP binding//cation channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0033644 host cell membrane KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.41180 BF_2 160.43 3.92 1999 642923490 XP_008193532.1 1769 9.7e-195 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 75 1.82845e-28 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 1234 4.3e-134 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00159//PF00852 Pancreatic hormone peptide//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486//GO:0007165 protein glycosylation//signal transduction GO:0005179//GO:0008417 hormone activity//fucosyltransferase activity GO:0005576//GO:0016020 extracellular region//membrane KOG2619 Fucosyltransferase Cluster-8309.41182 BF_2 63.03 2.16 1508 270001943 EEZ98390.1 619 1.6e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 5.61734e-117 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 7.0e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.41183 BF_2 192.45 2.33 3739 478263448 ENN81809.1 1986 1.2e-219 hypothetical protein YQE_01814, partial [Dendroctonus ponderosae]>gi|478263929|gb|ENN82095.1| hypothetical protein YQE_01527, partial [Dendroctonus ponderosae] 817188109 XM_012433187.1 139 9.11915e-64 PREDICTED: Orussus abietinus tubulin alpha chain-like (LOC105704177), mRNA -- -- -- -- Q7Z3E2 973 1.5e-103 Coiled-coil domain-containing protein 186 OS=Homo sapiens GN=CCDC186 PE=1 SV=2 PF13014 KH domain -- -- GO:0003723 RNA binding -- -- KOG1376 Alpha tubulin Cluster-8309.41184 BF_2 7442.13 392.67 1080 111182472 ABH07674.1 1424 5.3e-155 gut-specific chitinase [Apriona germari]>gi|111182474|gb|ABH07675.1| gut-specific chitinase [Apriona germari] 111182471 DQ837584.1 444 0 Apriona germari gut-specific chitinase mRNA, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 656 2.5e-67 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0016998//GO:0005975//GO:0006032 cell wall macromolecule catabolic process//carbohydrate metabolic process//chitin catabolic process GO:0004568//GO:0043169//GO:0004553 chitinase activity//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.41185 BF_2 361.48 6.02 2801 270004464 EFA00912.1 1317 3.5e-142 hypothetical protein TcasGA2_TC003818 [Tribolium castaneum] 642917680 XM_008193104.1 197 3.90008e-96 PREDICTED: Tribolium castaneum poly(A) polymerase type 3 (LOC103312455), transcript variant X2, mRNA K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 Q6PCL9 1005 2.2e-107 Poly(A) polymerase gamma OS=Mus musculus GN=Papolg PE=1 SV=1 PF04928//PF04926 Poly(A) polymerase central domain//Poly(A) polymerase predicted RNA binding domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003723 polynucleotide adenylyltransferase activity//RNA binding -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.41186 BF_2 76.29 1.78 2082 642919403 XP_008191855.1 1871 1.5e-206 PREDICTED: ubiquitin carboxyl-terminal hydrolase 46 [Tribolium castaneum] 642919402 XM_008193633.1 582 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 46 (LOC663037), mRNA K11842 USP12_46 ubiquitin carboxyl-terminal hydrolase 12/46 http://www.genome.jp/dbget-bin/www_bget?ko:K11842 P62068 1430 8.5e-157 Ubiquitin carboxyl-terminal hydrolase 46 OS=Homo sapiens GN=USP46 PE=1 SV=1 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0036459//GO:0032183//GO:0070140 ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.41187 BF_2 844.32 12.94 3016 189234074 XP_970690.2 1301 2.7e-140 PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum]>gi|642912025|ref|XP_008199064.1| PREDICTED: aldose 1-epimerase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01785 galM, GALM aldose 1-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01785 Q66HG4 743 5.6e-77 Aldose 1-epimerase OS=Rattus norvegicus GN=Galm PE=1 SV=1 PF05365//PF01263 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like//Aldose 1-epimerase GO:0005975//GO:0006122 carbohydrate metabolic process//mitochondrial electron transport, ubiquinol to cytochrome c GO:0016853 isomerase activity GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane KOG1604 Predicted mutarotase Cluster-8309.41188 BF_2 625.94 4.40 6244 478250592 ENN71084.1 843 7.2e-87 hypothetical protein YQE_12017, partial [Dendroctonus ponderosae]>gi|546672947|gb|ERL84655.1| hypothetical protein D910_02082 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GLM5 402 4.1e-37 Desumoylating isopeptidase 1 OS=Xenopus laevis GN=desi1 PE=2 SV=1 PF06453 Type II heat-labile enterotoxin , B subunit (LT-IIB) GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG0324 Uncharacterized conserved protein Cluster-8309.41190 BF_2 123.00 4.59 1409 91079626 XP_967654.1 1329 7.2e-144 PREDICTED: 28S ribosomal protein S29, mitochondrial [Tribolium castaneum]>gi|270004472|gb|EFA00920.1| hypothetical protein TcasGA2_TC003826 [Tribolium castaneum] -- -- -- -- -- K17408 DAP3, MRPS29 small subunit ribosomal protein S29 http://www.genome.jp/dbget-bin/www_bget?ko:K17408 P82922 749 5.3e-78 28S ribosomal protein S29, mitochondrial OS=Bos taurus GN=DAP3 PE=1 SV=3 PF04659 Archaeal flagella protein GO:0097588//GO:0006915 archaeal or bacterial-type flagellum-dependent cell motility//apoptotic process -- -- GO:0005761//GO:0015935 mitochondrial ribosome//small ribosomal subunit KOG3928 Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3 Cluster-8309.41192 BF_2 44.21 0.48 4117 642939400 XP_008193248.1 467 1.9e-43 PREDICTED: uncharacterized protein LOC103312106 [Tribolium castaneum]>gi|270016475|gb|EFA12921.1| hypothetical protein TcasGA2_TC006991 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03073 TspO/MBR family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41194 BF_2 181.18 2.18 3759 91076338 XP_971007.1 1162 4.4e-124 PREDICTED: protein TAPT1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VED0 770 5.2e-80 Protein TAPT1 homolog OS=Drosophila melanogaster GN=CG7218 PE=2 SV=2 PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG2490 Predicted membrane protein Cluster-8309.41197 BF_2 469.24 3.06 6692 157111277 XP_001651466.1 5483 0.0e+00 AAEL005801-PA [Aedes aegypti]>gi|108878460|gb|EAT42685.1| AAEL005801-PA [Aedes aegypti] 170063636 XM_001867153.1 197 9.38404e-96 Culex quinquefasciatus bifunctional aminoacyl-tRNA synthetase, mRNA K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 P28668 5286 0.0e+00 Bifunctional glutamate/proline--tRNA ligase OS=Drosophila melanogaster GN=Aats-glupro PE=1 SV=2 PF03950//PF00587//PF00749//PF00992//PF00458//PF09180//PF02146 tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class I (E and Q), catalytic domain//Troponin//WHEP-TRS domain//Prolyl-tRNA synthetase, C-terminal//Sir2 family GO:0006433//GO:0006418//GO:0043039//GO:0006525//GO:0006560 prolyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0004827//GO:0000166//GO:0004812//GO:0016876//GO:0005524//GO:0070403 proline-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding//NAD+ binding GO:0005861//GO:0005737 troponin complex//cytoplasm KOG4163 Prolyl-tRNA synthetase Cluster-8309.41198 BF_2 30.60 0.75 2001 332374418 AEE62350.1 1308 2.8e-141 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01939 646 6.6e-66 Protein misato OS=Drosophila melanogaster GN=mst PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG2530 Members of tubulin/FtsZ family Cluster-8309.41199 BF_2 22.88 0.39 2760 642929063 XP_008195676.1 436 5.0e-40 PREDICTED: flocculation protein FLO11 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41201 BF_2 30.79 1.23 1331 270016044 EFA12492.1 500 9.1e-48 hypothetical protein TcasGA2_TC012892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938 Outer membrane protein (OmpH-like) -- -- GO:0051082 unfolded protein binding -- -- -- -- Cluster-8309.41202 BF_2 140.26 1.23 5045 123478871 XP_001322596.1 198 3.6e-12 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121905445|gb|EAY10373.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 159 4.9e-09 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023//PF04998 Ankyrin repeat//Ankyrin repeat//RNA polymerase Rpb1, domain 5 GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005515 DNA binding//DNA-directed RNA polymerase activity//protein binding GO:0005730 nucleolus -- -- Cluster-8309.41205 BF_2 268.00 2.14 5524 478256258 ENN76448.1 3712 0.0e+00 hypothetical protein YQE_06902, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O60287 465 1.8e-44 Nucleolar pre-ribosomal-associated protein 1 OS=Homo sapiens GN=URB1 PE=1 SV=4 -- -- -- -- -- -- -- -- KOG1791 Uncharacterized conserved protein Cluster-8309.41206 BF_2 19.00 1.15 976 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41207 BF_2 763.39 2.68 12193 642913916 XP_008201212.1 3044 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X1 [Tribolium castaneum] 755870656 XM_005181954.2 137 3.87123e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 P51812 2107 1.6e-234 Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1 PF06293//PF00069//PF07714//PF00433 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0016773//GO:0004674//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.41208 BF_2 52.07 1.06 2342 642933218 XP_008197312.1 1098 7.3e-117 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 687 1.4e-70 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.41211 BF_2 97.00 2.25 2088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41215 BF_2 315.87 3.93 3649 478256507 ENN76691.1 1019 1.6e-107 hypothetical protein YQE_06756, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AYR6 722 1.9e-74 Haloacid dehalogenase-like hydrolase domain-containing protein 2 OS=Rattus norvegicus GN=Hdhd2 PE=2 SV=1 PF00013 KH domain -- -- GO:0003723 RNA binding -- -- KOG3040 Predicted sugar phosphatase (HAD superfamily) Cluster-8309.41216 BF_2 306.54 9.54 1631 189235090 XP_968736.2 1849 4.2e-204 PREDICTED: transmembrane protein 184B isoform X1 [Tribolium castaneum]>gi|270004019|gb|EFA00467.1| hypothetical protein TcasGA2_TC003325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2VDL9 1088 3.0e-117 Transmembrane protein 184B OS=Bos taurus GN=TMEM184B PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2641 Predicted seven transmembrane receptor - rhodopsin family Cluster-8309.4122 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41221 BF_2 2123.23 12.51 7388 91079112 XP_975371.1 1029 2.3e-108 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 3.5e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF03370//PF03423//PF16760 Carbohydrate/starch-binding module (family 21)//Carbohydrate binding domain (family 25)//Starch/carbohydrate-binding module (family 53) -- -- GO:0005515//GO:2001070 protein binding//starch binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.41222 BF_2 14.99 0.95 949 546685593 ERL95080.1 1153 1.2e-123 hypothetical protein D910_12350 [Dendroctonus ponderosae] 116194437 XM_001223030.1 57 8.64257e-19 Chaetomium globosum CBS 148.51 hypothetical protein (CHGG_03817) partial mRNA K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q9D4H8 572 1.2e-57 Cullin-2 OS=Mus musculus GN=Cul2 PE=1 SV=2 PF06180//PF00888//PF08469 Cobalt chelatase (CbiK)//Cullin family//Nucleoside triphosphatase I C-terminal GO:0006783//GO:0006511//GO:0019251//GO:0006351 heme biosynthetic process//ubiquitin-dependent protein catabolic process//anaerobic cobalamin biosynthetic process//transcription, DNA-templated GO:0017111//GO:0016852//GO:0031625//GO:0005524 nucleoside-triphosphatase activity//sirohydrochlorin cobaltochelatase activity//ubiquitin protein ligase binding//ATP binding -- -- KOG2166 Cullins Cluster-8309.41223 BF_2 96.87 8.45 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41226 BF_2 39.27 0.35 4995 102939 1952 1.5e-215 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1414 1.5e-154 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF03125 C. elegans Sre G protein-coupled chemoreceptor GO:0007606 sensory perception of chemical stimulus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41227 BF_2 1384.63 10.82 5642 91078042 XP_966587.1 1300 6.6e-140 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 792 2.2e-82 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41228 BF_2 1159.50 9.61 5334 642918375 XP_008200060.1 2520 2.1e-281 PREDICTED: ankyrin-2-like isoform X5 [Tribolium castaneum] 836709203 XM_012933675.1 98 8.07768e-41 PREDICTED: Sorex araneus ankyrin 2, neuronal (ANK2), mRNA K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 G5E8K5 1191 1.1e-128 Ankyrin-3 OS=Mus musculus GN=Ank3 PE=1 SV=1 PF00531 Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.41229 BF_2 307.00 7.48 2003 546685505 ERL95003.1 803 1.0e-82 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02106 Fanconi anaemia group C protein GO:0006281 DNA repair -- -- -- -- -- -- Cluster-8309.41230 BF_2 34.00 18.85 359 546685504 ERL95002.1 152 5.5e-08 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41231 BF_2 204.64 3.21 2954 91086723 XP_970869.1 1296 1.0e-139 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 7.76752e-09 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 697 1.2e-71 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF05637//PF02535 galactosyl transferase GMA12/MNN10 family//ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0016757//GO:0046873 transferase activity, transferring glycosyl groups//metal ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2693 Putative zinc transporter Cluster-8309.41233 BF_2 26.01 0.39 3102 189234428 XP_001816488.1 3520 0.0e+00 PREDICTED: coatomer subunit beta [Tribolium castaneum]>gi|270001762|gb|EEZ98209.1| hypothetical protein TcasGA2_TC000641 [Tribolium castaneum] 831211679 XM_003781123.2 112 7.71241e-49 PREDICTED: Otolemur garnettii coatomer protein complex, subunit beta 1 (COPB1), mRNA K17301 COPB1, SEC26 coatomer, subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K17301 P45437 2857 0.0e+00 Coatomer subunit beta OS=Drosophila melanogaster GN=betaCop PE=2 SV=2 PF01602//PF07718//PF00514//PF02985 Adaptin N terminal region//Coatomer beta C-terminal region//Armadillo/beta-catenin-like repeat//HEAT repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117//GO:0030126 membrane coat//COPI vesicle coat KOG1058 Vesicle coat complex COPI, beta subunit Cluster-8309.41234 BF_2 25.44 1.48 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41236 BF_2 81.40 1.24 3044 642924809 XP_008194049.1 1178 5.0e-126 PREDICTED: nuclear receptor coactivator 7 isoform X1 [Tribolium castaneum] 749755570 XM_011141969.1 132 5.76709e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q6DFV7 555 3.6e-55 Nuclear receptor coactivator 7 OS=Mus musculus GN=Ncoa7 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.41237 BF_2 29.00 0.92 1602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41238 BF_2 49.05 0.45 4852 642924817 XP_008194053.1 3497 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X5 [Tribolium castaneum] 749755570 XM_011141969.1 132 9.23348e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 6.1e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.41242 BF_2 642.87 15.77 1992 751230832 XP_011168942.1 177 3.9e-10 PREDICTED: vascular endothelial growth factor A-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00341 PDGF/VEGF domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity GO:0016020 membrane -- -- Cluster-8309.41243 BF_2 1386.90 12.15 5064 642935257 XP_008197935.1 1572 1.7e-171 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 429 2.4e-40 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.41244 BF_2 394.33 4.52 3935 91083595 XP_968896.1 1885 6.8e-208 PREDICTED: autophagy-related protein 9A [Tribolium castaneum]>gi|270006840|gb|EFA03288.1| hypothetical protein TcasGA2_TC013228 [Tribolium castaneum] 642924119 XM_963803.2 67 1.01609e-23 PREDICTED: Tribolium castaneum autophagy-related protein 9A (LOC657338), mRNA K17907 ATG9 autophagy-related protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K17907 Q3T904 1464 1.8e-160 Autophagy-related protein 9A OS=Bos taurus GN=ATG9A PE=2 SV=1 PF04828 Glutathione-dependent formaldehyde-activating enzyme GO:0008152 metabolic process GO:0016846 carbon-sulfur lyase activity -- -- KOG2173 Integral membrane protein Cluster-8309.41247 BF_2 129.35 1.53 3826 642934677 XP_008197764.1 940 2.5e-98 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X3 [Tribolium castaneum] 642934684 XM_008199547.1 208 4.10347e-102 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 239 2.0e-18 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF01434 Peptidase family M41 GO:0006508 proteolysis GO:0004222//GO:0005524 metalloendopeptidase activity//ATP binding -- -- -- -- Cluster-8309.41248 BF_2 1242.49 17.15 3317 642928315 XP_008195531.1 1039 7.2e-110 PREDICTED: microtubule-associated protein RP/EB family member 1 [Tribolium castaneum] 817062491 XM_012397482.1 89 5.03795e-36 PREDICTED: Athalia rosae microtubule-associated protein RP/EB family member 1 (LOC105684257), transcript variant X6, mRNA K10436 MAPRE microtubule-associated protein, RP/EB family http://www.genome.jp/dbget-bin/www_bget?ko:K10436 Q66T82 749 1.2e-77 Microtubule-associated protein RP/EB family member 1 OS=Coturnix coturnix japonica GN=MAPRE1 PE=2 SV=1 PF06070//PF00307//PF03271//PF05361 Herpesvirus large structural phosphoprotein UL32//Calponin homology (CH) domain//EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation GO:0008017//GO:0005515//GO:0005198 microtubule binding//protein binding//structural molecule activity GO:0045298//GO:0005737 tubulin complex//cytoplasm KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.41249 BF_2 264.82 3.86 3158 478252036 ENN72467.1 879 2.4e-91 hypothetical protein YQE_10809, partial [Dendroctonus ponderosae] 586460488 XM_006860838.1 137 9.94551e-63 PREDICTED: Chrysochloris asiatica NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (NDUFS8), mRNA K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 P42028 772 2.6e-80 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Bos taurus GN=NDUFS8 PE=1 SV=1 PF03194//PF05187//PF08782 LUC7 N_terminus//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S//c-SKI Smad4 binding domain GO:0055114//GO:0006376 oxidation-reduction process//mRNA splice site selection GO:0003729//GO:0046332//GO:0004174 mRNA binding//SMAD binding//electron-transferring-flavoprotein dehydrogenase activity GO:0005685 U1 snRNP KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit Cluster-8309.41250 BF_2 1946.00 26.16 3399 91078182 XP_967647.1 1956 3.4e-216 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IW92 1045 6.1e-112 Beta-galactosidase-1-like protein 2 OS=Homo sapiens GN=GLB1L2 PE=2 SV=1 PF02449 Beta-galactosidase GO:0046486//GO:0005975//GO:0006687//GO:0006027//GO:0008152//GO:0006012 glycerolipid metabolic process//carbohydrate metabolic process//glycosphingolipid metabolic process//glycosaminoglycan catabolic process//metabolic process//galactose metabolic process GO:0004565//GO:0004553 beta-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.41256 BF_2 36.00 1.60 1231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41262 BF_2 2311.99 388.53 536 642928380 XP_008192720.1 345 3.4e-30 PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|642928382|ref|XP_008192721.1| PREDICTED: uncharacterized protein LOC103312833 [Tribolium castaneum]>gi|270010784|gb|EFA07232.1| hypothetical protein TcasGA2_TC010589 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41263 BF_2 859.72 13.10 3033 546676276 ERL87322.1 1518 1.9e-165 hypothetical protein D910_04717 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGU5 692 4.6e-71 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF13174//PF13181//PF13414//PF08515//PF13176//PF07688//PF00515//PF13374//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Transforming growth factor beta type I GS-motif//Tetratricopeptide repeat//KaiA domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0007178//GO:0006468//GO:0007623//GO:0009069//GO:0016310 transmembrane receptor protein serine/threonine kinase signaling pathway//protein phosphorylation//circadian rhythm//serine family amino acid metabolic process//phosphorylation GO:0004675//GO:0005524//GO:0005515 transmembrane receptor protein serine/threonine kinase activity//ATP binding//protein binding GO:0016020 membrane -- -- Cluster-8309.41265 BF_2 470.59 2.47 8243 642924594 XP_008194356.1 1523 1.3e-165 PREDICTED: schwannomin-interacting protein 1-like [Tribolium castaneum]>gi|270007957|gb|EFA04405.1| hypothetical protein TcasGA2_TC014704 [Tribolium castaneum] 642924593 XM_008196134.1 273 6.5344e-138 PREDICTED: Tribolium castaneum schwannomin-interacting protein 1-like (LOC103313273), mRNA -- -- -- -- Q9H3K2 605 1.5e-60 Growth hormone-inducible transmembrane protein OS=Homo sapiens GN=GHITM PE=1 SV=2 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG4847 Coiled coil protein involved in linking membrane proteins to cytoskeleton Cluster-8309.41266 BF_2 1458.61 15.42 4243 642916660 XP_008192067.1 4186 0.0e+00 PREDICTED: serine/threonine-protein kinase N isoform X3 [Tribolium castaneum] 242022369 XM_002431568.1 129 3.75269e-58 Pediculus humanus corporis conserved hypothetical protein, mRNA K06071 PKN protein kinase N http://www.genome.jp/dbget-bin/www_bget?ko:K06071 Q16513 2483 1.4e-278 Serine/threonine-protein kinase N2 OS=Homo sapiens GN=PKN2 PE=1 SV=1 PF07714//PF00433//PF00069//PF02185 Protein tyrosine kinase//Protein kinase C terminal domain//Protein kinase domain//Hr1 repeat GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0694 Serine/threonine protein kinase Cluster-8309.41267 BF_2 179.38 1.06 7339 91083005 XP_974497.1 1587 4.5e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit H [Tribolium castaneum]>gi|270007645|gb|EFA04093.1| hypothetical protein TcasGA2_TC014327 [Tribolium castaneum] -- -- -- -- -- K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1431 2.3e-156 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF00622//PF09596//PF07525//PF04961//PF01398 SPRY domain//MamL-1 domain//SOCS box//Formiminotransferase-cyclodeaminase//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0045944//GO:0007219//GO:0044237//GO:0035556 positive regulation of transcription from RNA polymerase II promoter//Notch signaling pathway//cellular metabolic process//intracellular signal transduction GO:0003824//GO:0005515//GO:0003713 catalytic activity//protein binding//transcription coactivator activity GO:0005667//GO:0016607 transcription factor complex//nuclear speck KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-8309.41268 BF_2 1273.70 7.58 7314 91083005 XP_974497.1 1587 4.5e-173 PREDICTED: eukaryotic translation initiation factor 3 subunit H [Tribolium castaneum]>gi|270007645|gb|EFA04093.1| hypothetical protein TcasGA2_TC014327 [Tribolium castaneum] -- -- -- -- -- K03247 EIF3H translation initiation factor 3 subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K03247 Q9GV27 1431 2.3e-156 Eukaryotic translation initiation factor 3 subunit H OS=Bombyx mori PE=2 SV=1 PF01398//PF04961//PF09596//PF07525 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//MamL-1 domain//SOCS box GO:0035556//GO:0007219//GO:0045944//GO:0044237 intracellular signal transduction//Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0005515//GO:0003713 catalytic activity//protein binding//transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex KOG1560 Translation initiation factor 3, subunit h (eIF-3h) Cluster-8309.41269 BF_2 72.25 4.55 952 642919915 XP_008192123.1 954 1.5e-100 PREDICTED: ankyrin repeat and sterile alpha motif domain-containing protein 1B [Tribolium castaneum] 462448440 APGK01008686.1 56 3.11861e-18 Dendroctonus ponderosae Seq01008694, whole genome shotgun sequence -- -- -- -- Q8BIZ1 563 1.3e-56 Ankyrin repeat and sterile alpha motif domain-containing protein 1B OS=Mus musculus GN=Anks1b PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41270 BF_2 16.23 0.36 2180 270008906 EFA05354.1 1818 2.2e-200 hypothetical protein TcasGA2_TC015519 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1607 2.6e-177 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654//PF02934 Voltage gated chloride channel//GatB/GatE catalytic domain GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247//GO:0016874 voltage-gated chloride channel activity//ligase activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.41272 BF_2 243.70 3.77 2988 91078814 XP_970649.1 1632 1.1e-178 PREDICTED: ran GTPase-activating protein 1 [Tribolium castaneum]>gi|270003723|gb|EFA00171.1| hypothetical protein TcasGA2_TC002993 [Tribolium castaneum] -- -- -- -- -- K14319 RANGAP1 Ran GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14319 P46060 862 8.9e-91 Ran GTPase-activating protein 1 OS=Homo sapiens GN=RANGAP1 PE=1 SV=1 PF06524//PF13516//PF07834//PF13855//PF04546 NOA36 protein//Leucine Rich repeat//RanGAP1 C-terminal domain//Leucine rich repeat//Sigma-70, non-essential region GO:0006352//GO:0006355//GO:0050794//GO:0007165 DNA-templated transcription, initiation//regulation of transcription, DNA-templated//regulation of cellular process//signal transduction GO:0003700//GO:0016987//GO:0008270//GO:0005515//GO:0003677//GO:0005096 transcription factor activity, sequence-specific DNA binding//sigma factor activity//zinc ion binding//protein binding//DNA binding//GTPase activator activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1909 Ran GTPase-activating protein Cluster-8309.41273 BF_2 253.30 3.67 3172 91078814 XP_970649.1 1634 6.9e-179 PREDICTED: ran GTPase-activating protein 1 [Tribolium castaneum]>gi|270003723|gb|EFA00171.1| hypothetical protein TcasGA2_TC002993 [Tribolium castaneum] -- -- -- -- -- K14319 RANGAP1 Ran GTPase-activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14319 P46060 862 9.4e-91 Ran GTPase-activating protein 1 OS=Homo sapiens GN=RANGAP1 PE=1 SV=1 PF04546//PF07834//PF13516//PF13855//PF06524 Sigma-70, non-essential region//RanGAP1 C-terminal domain//Leucine Rich repeat//Leucine rich repeat//NOA36 protein GO:0007165//GO:0050794//GO:0006355//GO:0006352 signal transduction//regulation of cellular process//regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0005096//GO:0005515//GO:0008270//GO:0016987//GO:0003700 DNA binding//GTPase activator activity//protein binding//zinc ion binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1909 Ran GTPase-activating protein Cluster-8309.41274 BF_2 79.54 5.64 877 642925292 XP_001814214.2 395 9.0e-36 PREDICTED: uncharacterized protein LOC100142468 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41275 BF_2 37.60 0.51 3344 478254773 ENN75009.1 1721 6.0e-189 hypothetical protein YQE_08326, partial [Dendroctonus ponderosae]>gi|546674398|gb|ERL85785.1| hypothetical protein D910_03200 [Dendroctonus ponderosae] 768418305 XM_011551531.1 267 5.70372e-135 PREDICTED: Plutella xylostella serine/threonine-protein phosphatase alpha-2 isoform (LOC105381736), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q6NVU2 1617 2.8e-178 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit OS=Xenopus tropicalis GN=ppp1cc PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.41276 BF_2 4399.46 24.93 7669 642917448 XP_008191204.1 2754 2.3e-308 PREDICTED: maternal protein tudor isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25823 542 2.9e-53 Maternal protein tudor OS=Drosophila melanogaster GN=tud PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41278 BF_2 41.45 2.34 1028 642928987 XP_008195646.1 336 7.3e-29 PREDICTED: WD repeat-containing protein 74 [Tribolium castaneum]>gi|270009716|gb|EFA06164.1| hypothetical protein TcasGA2_TC009011 [Tribolium castaneum] -- -- -- -- -- K14841 NSA1, WDR74 ribosome biogenesis protein NSA1 http://www.genome.jp/dbget-bin/www_bget?ko:K14841 Q54FW9 141 1.2e-07 WD repeat-containing protein DDB_G0290555 OS=Dictyostelium discoideum GN=DDB_G0290555 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG3881 Uncharacterized conserved protein Cluster-8309.41280 BF_2 146.63 2.33 2925 642914454 XP_008201683.1 669 5.1e-67 PREDICTED: proteoglycan 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41282 BF_2 780.00 9.05 3893 270013723 EFA10171.1 4273 0.0e+00 hypothetical protein TcasGA2_TC012361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 1184 5.3e-128 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF02460//PF00873 Patched family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165 transport//signal transduction GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane KOG1934 Predicted membrane protein (patched superfamily) Cluster-8309.41283 BF_2 6286.00 97.61 2981 91081489 XP_976188.1 3027 0.0e+00 PREDICTED: V-type proton ATPase catalytic subunit A [Tribolium castaneum]>gi|270006460|gb|EFA02908.1| NtpA [Tribolium castaneum] 751448908 XM_011180358.1 701 0 PREDICTED: Bactrocera cucurbitae V-type proton ATPase catalytic subunit A isoform 2 (LOC105209762), transcript variant X2, mRNA K02145 ATPeV1A, ATP6A V-type H+-transporting ATPase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02145 O16109 2932 0.0e+00 V-type proton ATPase catalytic subunit A OS=Aedes aegypti GN=VhaA PE=2 SV=2 PF00006//PF00306//PF02874//PF11883 ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, beta-barrel domain//Domain of unknown function (DUF3403) GO:0015986//GO:0015992//GO:0015991//GO:0016310//GO:0046034//GO:0006119//GO:0009069 ATP synthesis coupled proton transport//proton transport//ATP hydrolysis coupled proton transport//phosphorylation//ATP metabolic process//oxidative phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0046961//GO:0046933//GO:0005524//GO:0016820 protein serine/threonine kinase activity//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033180//GO:0045259//GO:0033178 proton-transporting V-type ATPase, V1 domain//proton-transporting ATP synthase complex//proton-transporting two-sector ATPase complex, catalytic domain KOG1352 Vacuolar H+-ATPase V1 sector, subunit A Cluster-8309.41284 BF_2 52.38 1.04 2395 189240983 XP_966935.2 1213 3.4e-130 PREDICTED: DDB1- and CUL4-associated factor 10 homolog [Tribolium castaneum]>gi|270012997|gb|EFA09445.1| hypothetical protein TcasGA2_TC010660 [Tribolium castaneum] -- -- -- -- -- K11802 WDR32 WD repeat-containing protein 32 http://www.genome.jp/dbget-bin/www_bget?ko:K11802 Q9VAT2 447 9.4e-43 DDB1- and CUL4-associated factor 10 homolog OS=Drosophila melanogaster GN=CG1523 PE=1 SV=1 PF00400//PF08447 WD domain, G-beta repeat//PAS fold -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41285 BF_2 211.03 2.63 3640 478250663 ENN71155.1 1488 6.8e-162 hypothetical protein YQE_12086, partial [Dendroctonus ponderosae]>gi|546677247|gb|ERL88116.1| hypothetical protein D910_05505 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P19967 801 1.3e-83 Cytochrome b5-related protein OS=Drosophila melanogaster GN=Cyt-b5-r PE=2 SV=2 PF08320//PF00487 PIG-X / PBN1//Fatty acid desaturase GO:0006506//GO:0006629 GPI anchor biosynthetic process//lipid metabolic process -- -- GO:0005789 endoplasmic reticulum membrane KOG0537 Cytochrome b5 Cluster-8309.41287 BF_2 51.41 0.66 3562 91076618 XP_969384.1 252 1.4e-18 PREDICTED: trypsin II-P29 [Tribolium castaneum]>gi|270002914|gb|EEZ99361.1| serine protease H59 [Tribolium castaneum] -- -- -- -- -- K09643 TMPRSS13, TMPRSS11 transmembrane protease, serine 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09643 Q9BYE2 181 9.8e-12 Transmembrane protease serine 13 OS=Homo sapiens GN=TMPRSS13 PE=2 SV=4 PF16048//PF00089//PF11057 Frog antimicrobial peptide//Trypsin//Cortexin of kidney GO:0006952//GO:0006508 defense response//proteolysis GO:0004252 serine-type endopeptidase activity GO:0031224//GO:0005576 intrinsic component of membrane//extracellular region -- -- Cluster-8309.41288 BF_2 114.15 22.63 498 642922794 XP_008193328.1 427 9.9e-40 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 255 3.6e-21 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41292 BF_2 178.76 3.16 2657 642930948 XP_008196153.1 1518 1.6e-165 PREDICTED: protein diaphanous isoform X3 [Tribolium castaneum] 642930947 XM_008197931.1 56 8.90462e-18 PREDICTED: Tribolium castaneum protein diaphanous (LOC660495), transcript variant X3, mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 771 2.8e-80 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF10508//PF06371//PF06367 Proteasome non-ATPase 26S subunit//Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain GO:0016043//GO:0030036//GO:0043248 cellular component organization//actin cytoskeleton organization//proteasome assembly GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1924 RhoA GTPase effector DIA/Diaphanous Cluster-8309.41294 BF_2 73.56 7.77 683 642931342 XP_008196538.1 211 1.5e-14 PREDICTED: gametocyte-specific factor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41295 BF_2 618.00 15.48 1957 642937654 XP_008198887.1 1624 6.2e-178 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q0VD19 807 1.4e-84 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 PF13085//PF00149 2Fe-2S iron-sulfur cluster binding domain//Calcineurin-like phosphoesterase GO:0006118 obsolete electron transport GO:0016787//GO:0051536//GO:0009055 hydrolase activity//iron-sulfur cluster binding//electron carrier activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.41296 BF_2 1096.59 6.63 7202 642936633 XP_008198516.1 3002 0.0e+00 PREDICTED: trafficking kinesin-binding protein milt isoform X1 [Tribolium castaneum]>gi|270013061|gb|EFA09509.1| hypothetical protein TcasGA2_TC011611 [Tribolium castaneum] 642936632 XM_008200294.1 341 9.02192e-176 PREDICTED: Tribolium castaneum trafficking kinesin-binding protein milt (LOC661863), transcript variant X1, mRNA K15369 TRAK1 trafficking kinesin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15369 Q960V3 741 2.3e-76 Trafficking kinesin-binding protein milt OS=Drosophila melanogaster GN=milt PE=1 SV=1 PF06009//PF04111//PF15182//PF04513//PF08702//PF01496//PF02262 Laminin Domain II//Autophagy protein Apg6//Otospiralin//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//V-type ATPase 116kDa subunit family//CBL proto-oncogene N-terminal domain 1 GO:0030168//GO:0007155//GO:0015991//GO:0007166//GO:0015992//GO:0007165//GO:0007605//GO:0051258//GO:0006914 platelet activation//cell adhesion//ATP hydrolysis coupled proton transport//cell surface receptor signaling pathway//proton transport//signal transduction//sensory perception of sound//protein polymerization//autophagy GO:0004871//GO:0030674//GO:0015078//GO:0005102//GO:0005198 signal transducer activity//protein binding, bridging//hydrogen ion transmembrane transporter activity//receptor binding//structural molecule activity GO:0033179//GO:0005634//GO:0019031//GO:0005577//GO:0019028 proton-transporting V-type ATPase, V0 domain//nucleus//viral envelope//fibrinogen complex//viral capsid -- -- Cluster-8309.41297 BF_2 161.61 3.24 2372 478263612 ENN81918.1 2067 3.2e-229 hypothetical protein YQE_01630, partial [Dendroctonus ponderosae] 768432559 XM_011559308.1 120 2.10009e-53 PREDICTED: Plutella xylostella succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial (LOC105388405), mRNA K01027 OXCT 3-oxoacid CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K01027 Q9D0K2 1654 1.0e-182 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial OS=Mus musculus GN=Oxct1 PE=1 SV=1 PF00816//PF01144 H-NS histone family//Coenzyme A transferase GO:0006355//GO:0008152 regulation of transcription, DNA-templated//metabolic process GO:0003677//GO:0008410 DNA binding//CoA-transferase activity GO:0005622 intracellular KOG3822 Succinyl-CoA:alpha-ketoacid-CoA transferase Cluster-8309.41299 BF_2 1823.19 23.13 3585 91085847 XP_974980.1 1266 3.7e-136 PREDICTED: LIM and SH3 domain protein F42H10.3 [Tribolium castaneum]>gi|270010142|gb|EFA06590.1| hypothetical protein TcasGA2_TC009504 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34416 689 1.2e-70 LIM and SH3 domain protein F42H10.3 OS=Caenorhabditis elegans GN=F42H10.3 PE=3 SV=3 PF00412//PF00018//PF14604 LIM domain//SH3 domain//Variant SH3 domain -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG1702 Nebulin repeat protein Cluster-8309.41300 BF_2 61.93 0.68 4096 642936999 XP_968421.2 1046 1.4e-110 PREDICTED: 60 kDa SS-A/Ro ribonucleoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42700 350 2.8e-31 60 kDa SS-A/Ro ribonucleoprotein OS=Xenopus laevis GN=trove2 PE=1 SV=1 PF02285//PF05731 Cytochrome oxidase c subunit VIII//TROVE domain GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003723 cytochrome-c oxidase activity//RNA binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.41301 BF_2 737.32 8.22 4041 642936999 XP_968421.2 1046 1.3e-110 PREDICTED: 60 kDa SS-A/Ro ribonucleoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42700 350 2.8e-31 60 kDa SS-A/Ro ribonucleoprotein OS=Xenopus laevis GN=trove2 PE=1 SV=1 PF05731//PF02285 TROVE domain//Cytochrome oxidase c subunit VIII GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003723 cytochrome-c oxidase activity//RNA binding GO:0045277 respiratory chain complex IV -- -- Cluster-8309.41304 BF_2 11.85 1.03 769 642912447 XP_008200864.1 372 3.6e-33 PREDICTED: LOW QUALITY PROTEIN: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06657//PF01025//PF15070//PF02185//PF10473//PF06005//PF01017//PF10186//PF07352//PF16326//PF04977//PF03449//PF05615 Centrosome microtubule-binding domain of Cep57//GrpE//Putative golgin subfamily A member 2-like protein 5//Hr1 repeat//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Protein of unknown function (DUF904)//STAT protein, all-alpha domain//Vacuolar sorting 38 and autophagy-related subunit 14//Bacteriophage Mu Gam like protein//ABC transporter C-terminal domain//Septum formation initiator//Transcription elongation factor, N-terminal//Tho complex subunit 7 GO:0042262//GO:0006457//GO:0006397//GO:0043093//GO:0000917//GO:0032784//GO:0007165//GO:0010508//GO:0007049//GO:0006355 DNA protection//protein folding//mRNA processing//FtsZ-dependent cytokinesis//barrier septum assembly//regulation of DNA-templated transcription, elongation//signal transduction//positive regulation of autophagy//cell cycle//regulation of transcription, DNA-templated GO:0003677//GO:0003690//GO:0042803//GO:0004871//GO:0008017//GO:0045502//GO:0008134//GO:0003700//GO:0051087//GO:0000774 DNA binding//double-stranded DNA binding//protein homodimerization activity//signal transducer activity//microtubule binding//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//chaperone binding//adenyl-nucleotide exchange factor activity GO:0005667//GO:0030286//GO:0005794//GO:0045298//GO:0000445//GO:0005737 transcription factor complex//dynein complex//Golgi apparatus//tubulin complex//THO complex part of transcription export complex//cytoplasm -- -- Cluster-8309.41305 BF_2 114.41 1.30 3973 642938512 XP_008195463.1 842 6.0e-87 PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum]>gi|642938514|ref|XP_008195504.1| PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00591 COQ3 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00591 Q63159 602 1.7e-60 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Rattus norvegicus GN=Coq3 PE=2 SV=2 PF03602//PF01209//PF05401//PF08241//PF02527//PF05175//PF00891//PF09445 Conserved hypothetical protein 95//ubiE/COQ5 methyltransferase family//Nodulation protein S (NodS)//Methyltransferase domain//rRNA small subunit methyltransferase G//Methyltransferase small domain//O-methyltransferase//RNA cap guanine-N2 methyltransferase GO:0001510//GO:0009312//GO:0008152//GO:0009452//GO:0031167//GO:0006364//GO:0009877//GO:0006396//GO:0000154 RNA methylation//oligosaccharide biosynthetic process//metabolic process//7-methylguanosine RNA capping//rRNA methylation//rRNA processing//nodulation//RNA processing//rRNA modification GO:0008757//GO:0008171//GO:0008649//GO:0008168 S-adenosylmethionine-dependent methyltransferase activity//O-methyltransferase activity//rRNA methyltransferase activity//methyltransferase activity GO:0005737 cytoplasm KOG1270 Methyltransferases Cluster-8309.41306 BF_2 148.70 2.58 2696 91090278 XP_970876.1 767 2.0e-78 PREDICTED: cell division control protein 42 homolog [Tribolium castaneum]>gi|270014293|gb|EFA10741.1| hypothetical protein TcasGA2_TC012434 [Tribolium castaneum] -- -- -- -- -- K07865 RHOU, WRCH1 Ras homolog gene family, member U http://www.genome.jp/dbget-bin/www_bget?ko:K07865 Q9EQT3 457 7.3e-44 Rho-related GTP-binding protein RhoU OS=Mus musculus GN=Rhou PE=2 SV=1 PF01926//PF03193//PF08477//PF00025//PF00071 50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005525 GTPase activity//GTP binding GO:0005622//GO:0016020 intracellular//membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.41307 BF_2 85.18 0.64 5887 642935247 XP_008197929.1 4988 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 773 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1799 3.9e-199 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF16656//PF00041//PF13895//PF05506//PF01213 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//Domain of unknown function (DUF756)//Adenylate cyclase associated (CAP) N terminal GO:0006771//GO:0016042//GO:0009395//GO:0007010//GO:0019497 riboflavin metabolic process//lipid catabolic process//phospholipid catabolic process//cytoskeleton organization//hexachlorocyclohexane metabolic process GO:0003993//GO:0004629//GO:0046872//GO:0005515//GO:0003779 acid phosphatase activity//phospholipase C activity//metal ion binding//protein binding//actin binding -- -- -- -- Cluster-8309.41309 BF_2 25.00 11.02 380 657792115 XP_008322921.1 256 5.1e-20 PREDICTED: zinc finger MYM-type protein 1-like [Cynoglossus semilaevis] -- -- -- -- -- -- -- -- -- Q5SVZ6 121 9.4e-06 Zinc finger MYM-type protein 1 OS=Homo sapiens GN=ZMYM1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4131 BF_2 5.99 1.33 475 642931265 XP_008196504.1 188 4.9e-12 PREDICTED: high mobility group B protein 13-like [Tribolium castaneum]>gi|270012132|gb|EFA08580.1| hypothetical protein TcasGA2_TC006235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41312 BF_2 81.61 1.15 3266 642919300 XP_008191816.1 1453 6.9e-158 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64634 648 6.3e-66 UDP-glucuronosyltransferase 1-8 OS=Rattus norvegicus GN=Ugt1a8 PE=2 SV=1 PF04101//PF13409//PF02419//PF00201 Glycosyltransferase family 28 C-terminal domain//Glutathione S-transferase, N-terminal domain//PsbL protein//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0015979 metabolic process//photosynthesis GO:0016758//GO:0005515 transferase activity, transferring hexosyl groups//protein binding GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.41313 BF_2 1446.45 21.58 3091 642919300 XP_008191816.1 1453 6.6e-158 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64634 648 6.0e-66 UDP-glucuronosyltransferase 1-8 OS=Rattus norvegicus GN=Ugt1a8 PE=2 SV=1 PF13409//PF00201//PF04101 Glutathione S-transferase, N-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0005515//GO:0016758 protein binding//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.41314 BF_2 1109.00 13.21 3798 642915122 XP_008190418.1 736 1.1e-74 PREDICTED: uncharacterized protein LOC103312186 [Tribolium castaneum]>gi|270002873|gb|EEZ99320.1| bifocal [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03410 Metallopeptidase from vaccinia pox GO:0019058 viral life cycle GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.41316 BF_2 23.52 0.44 2512 91080341 XP_974659.1 557 4.2e-54 PREDICTED: ADP-ribosylation factor GTPase-activating protein 2 [Tribolium castaneum]>gi|270005715|gb|EFA02163.1| hypothetical protein TcasGA2_TC007817 [Tribolium castaneum] -- -- -- -- -- K12493 ARFGAP2_3 ADP-ribosylation factor GTPase-activating protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12493 Q17R07 270 3.3e-22 ADP-ribosylation factor GTPase-activating protein 3 OS=Bos taurus GN=ARFGAP3 PE=2 SV=1 PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- KOG0706 Predicted GTPase-activating protein Cluster-8309.41318 BF_2 166.57 10.89 927 642923010 XP_973133.3 600 1.6e-59 PREDICTED: transcription factor GATA-4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41319 BF_2 88.08 1.42 2887 642924612 XP_008194363.1 852 3.0e-88 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41320 BF_2 3.00 0.44 574 189238487 XP_969483.2 303 2.7e-25 PREDICTED: trichoplein keratin filament-binding protein-like [Tribolium castaneum] -- -- -- -- -- K16811 TCHP trichoplein keratin filament-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K16811 Q1RM03 136 2.6e-07 Trichoplein keratin filament-binding protein OS=Danio rerio GN=tchp PE=2 SV=1 PF05279//PF13304 Aspartyl beta-hydroxylase N-terminal region//AAA domain, putative AbiEii toxin, Type IV TA system -- -- GO:0005524 ATP binding GO:0016020 membrane -- -- Cluster-8309.41321 BF_2 397.01 3.06 5708 642925019 XP_008194138.1 3847 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X2 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.97512e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.8e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.41323 BF_2 1603.95 42.26 1875 749747448 XP_011135848.1 1108 4.0e-118 PREDICTED: casein kinase II subunit beta isoform X1 [Harpegnathos saltator] 642914880 XM_961220.2 352 0 PREDICTED: Tribolium castaneum casein kinase II subunit beta (LOC658630), transcript variant X1, mRNA K03115 CSNK2B casein kinase II subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03115 O76485 1031 1.4e-110 Casein kinase II subunit beta OS=Spodoptera frugiperda PE=2 SV=1 PF01214 Casein kinase II regulatory subunit GO:0045859 regulation of protein kinase activity GO:0019887 protein kinase regulator activity GO:0005956 protein kinase CK2 complex KOG3092 Casein kinase II, beta subunit Cluster-8309.41324 BF_2 271.00 8.62 1603 478255841 ENN76049.1 1283 1.8e-138 hypothetical protein YQE_07422, partial [Dendroctonus ponderosae] -- -- -- -- -- K08669 HTRA2, PRSS25 HtrA serine peptidase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08669 B4JTT7 1093 7.8e-118 Serine protease HTRA2, mitochondrial OS=Drosophila grimshawi GN=HtrA2 PE=3 SV=1 PF00089//PF05579//PF00595//PF10459//PF13180 Trypsin//Equine arteritis virus serine endopeptidase S32//PDZ domain (Also known as DHR or GLGF)//Peptidase S46//PDZ domain GO:0006508//GO:0016032//GO:0019082 proteolysis//viral process//viral protein processing GO:0070009//GO:0008239//GO:0005515//GO:0004252 serine-type aminopeptidase activity//dipeptidyl-peptidase activity//protein binding//serine-type endopeptidase activity -- -- KOG1320 Serine protease Cluster-8309.41327 BF_2 127.72 0.79 7016 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41328 BF_2 2672.75 11.94 9651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41329 BF_2 164.00 11.48 885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41332 BF_2 352.16 8.06 2116 91092598 XP_970550.1 686 3.9e-69 PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|642921812|ref|XP_008199330.1| PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|270006629|gb|EFA03077.1| hypothetical protein TcasGA2_TC010951 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q8NEJ0 361 7.8e-33 Dual specificity protein phosphatase 18 OS=Homo sapiens GN=DUSP18 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0016311//GO:0006470//GO:0006570 dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0016791//GO:0004725//GO:0008138 phosphatase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1718 Dual specificity phosphatase Cluster-8309.41334 BF_2 47.00 20.92 379 -- -- -- -- -- 746815352 KF823855.1 134 5.13299e-62 Eukoenenia mirabilis voucher MCZ:IZ-127902 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41336 BF_2 51.75 0.45 5097 642929846 XP_008195999.1 1855 2.6e-204 PREDICTED: anoctamin-8 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q9HCE9 524 2.4e-51 Anoctamin-8 OS=Homo sapiens GN=ANO8 PE=1 SV=3 PF15724 TMEM119 family GO:0001503 ossification -- -- -- -- KOG2513 Protein required for meiotic chromosome segregation Cluster-8309.41337 BF_2 24.71 0.54 2191 478252720 ENN73115.1 375 4.7e-33 hypothetical protein YQE_10256, partial [Dendroctonus ponderosae] -- -- -- -- -- K12485 RAB11FIP3_4 Rab11 family-interacting protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K12485 -- -- -- -- PF02183//PF15898//PF08653//PF05837//PF01166//PF00170//PF06005//PF04977//PF06156//PF16331 Homeobox associated leucine zipper//cGMP-dependent protein kinase interacting domain//DASH complex subunit Dam1//Centromere protein H (CENP-H)//TSC-22/dip/bun family//bZIP transcription factor//Protein of unknown function (DUF904)//Septum formation initiator//Protein of unknown function (DUF972)//TolA binding protein trimerisation GO:0000917//GO:0043093//GO:0070206//GO:0051382//GO:0007049//GO:0006260//GO:0008608//GO:0006355 barrier septum assembly//FtsZ-dependent cytokinesis//protein trimerization//kinetochore assembly//cell cycle//DNA replication//attachment of spindle microtubules to kinetochore//regulation of transcription, DNA-templated GO:0003700//GO:0019901//GO:0043565 transcription factor activity, sequence-specific DNA binding//protein kinase binding//sequence-specific DNA binding GO:0005667//GO:0072686//GO:0000776//GO:0005737//GO:0042729 transcription factor complex//mitotic spindle//kinetochore//cytoplasm//DASH complex -- -- Cluster-8309.41338 BF_2 1298.87 11.11 5179 646722544 KDR23502.1 4689 0.0e+00 Dual oxidase 2 [Zootermopsis nevadensis] -- -- -- -- -- K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9NRD9 2752 1.1e-309 Dual oxidase 1 OS=Homo sapiens GN=DUOX1 PE=1 SV=1 PF12763//PF00175//PF13499//PF13833//PF13405//PF13202//PF08030//PF03185//PF15048//PF08022//PF00036 Cytoskeletal-regulatory complex EF hand//Oxidoreductase NAD-binding domain//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Ferric reductase NAD binding domain//Calcium-activated potassium channel, beta subunit//Organic solute transporter subunit beta protein//FAD-binding domain//EF hand GO:0006813//GO:0006810//GO:0015721//GO:0055114 potassium ion transport//transport//bile acid and bile salt transport//oxidation-reduction process GO:0005215//GO:0015269//GO:0016491//GO:0046982//GO:0005515//GO:0005509 transporter activity//calcium-activated potassium channel activity//oxidoreductase activity//protein heterodimerization activity//protein binding//calcium ion binding GO:0005886//GO:0016020 plasma membrane//membrane KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.41340 BF_2 95.27 1.07 4008 752891325 XP_011263696.1 1568 3.9e-171 PREDICTED: uncharacterized protein LOC105255869 [Camponotus floridanus] 752891324 XM_011265394.1 393 0 PREDICTED: Camponotus floridanus uncharacterized LOC105255869 (LOC105255869), mRNA -- -- -- -- -- -- -- -- PF07927 HicA toxin of bacterial toxin-antitoxin, -- -- GO:0003729 mRNA binding -- -- -- -- Cluster-8309.41341 BF_2 2109.50 7.64 11839 270015748 EFA12196.1 1838 5.7e-202 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TT16 248 5.5e-19 Inositol polyphosphate multikinase OS=Mus musculus GN=Ipmk PE=2 SV=1 PF01218//PF08702//PF01105//PF00642//PF10473//PF03938//PF13912//PF05529//PF16716//PF00096//PF00867//PF03770//PF04111//PF00695 Coproporphyrinogen III oxidase//Fibrinogen alpha/beta chain family//emp24/gp25L/p24 family/GOLD//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Outer membrane protein (OmpH-like)//C2H2-type zinc finger//B-cell receptor-associated protein 31-like//Bone marrow stromal antigen 2//Zinc finger, C2H2 type//XPG I-region//Inositol polyphosphate kinase//Autophagy protein Apg6//Major surface antigen from hepadnavirus GO:0006810//GO:0006886//GO:0006914//GO:0051258//GO:0007165//GO:0006779//GO:0055114//GO:0015994//GO:0051607//GO:0016032//GO:0030168 transport//intracellular protein transport//autophagy//protein polymerization//signal transduction//porphyrin-containing compound biosynthetic process//oxidation-reduction process//chlorophyll metabolic process//defense response to virus//viral process//platelet activation GO:0045502//GO:0008134//GO:0005102//GO:0008440//GO:0051082//GO:0004109//GO:0046872//GO:0004518//GO:0042803//GO:0030674 dynein binding//transcription factor binding//receptor binding//inositol-1,4,5-trisphosphate 3-kinase activity//unfolded protein binding//coproporphyrinogen oxidase activity//metal ion binding//nuclease activity//protein homodimerization activity//protein binding, bridging GO:0016021//GO:0005577//GO:0005783//GO:0005667//GO:0030286 integral component of membrane//fibrinogen complex//endoplasmic reticulum//transcription factor complex//dynein complex -- -- Cluster-8309.41342 BF_2 75.93 0.96 3609 642940455 XP_972983.2 926 9.9e-97 PREDICTED: tektin-1 [Tribolium castaneum]>gi|642940457|ref|XP_008196454.1| PREDICTED: tektin-1 [Tribolium castaneum] 768916438 XR_964517.1 62 5.60399e-21 PREDICTED: Takifugu rubripes cytochrome c oxidase assembly protein COX15 homolog (LOC101068591), transcript variant X2, misc_RNA K02259 COX15 cytochrome c oxidase assembly protein subunit 15 http://www.genome.jp/dbget-bin/www_bget?ko:K02259 Q08DG6 598 4.4e-60 Cytochrome c oxidase assembly protein COX15 homolog OS=Bos taurus GN=COX15 PE=2 SV=1 PF01544//PF02185//PF04799//PF02628//PF00944 CorA-like Mg2+ transporter protein//Hr1 repeat//fzo-like conserved region//Cytochrome oxidase assembly protein//Alphavirus core protein GO:0006784//GO:0055114//GO:0008053//GO:0006508//GO:0007165//GO:0030001//GO:0055085 heme a biosynthetic process//oxidation-reduction process//mitochondrial fusion//proteolysis//signal transduction//metal ion transport//transmembrane transport GO:0016627//GO:0004252//GO:0046873//GO:0003924 oxidoreductase activity, acting on the CH-CH group of donors//serine-type endopeptidase activity//metal ion transmembrane transporter activity//GTPase activity GO:0005741//GO:0016020//GO:0016021 mitochondrial outer membrane//membrane//integral component of membrane KOG2725 Cytochrome oxidase assembly factor COX15 Cluster-8309.41344 BF_2 50.90 0.52 4407 189240839 XP_001812334.1 2664 3.5e-298 PREDICTED: SWI/SNF complex subunit SMARCC2 [Tribolium castaneum]>gi|270013718|gb|EFA10166.1| hypothetical protein TcasGA2_TC012356 [Tribolium castaneum] 585702584 XM_006897683.1 41 3.23505e-09 PREDICTED: Elephantulus edwardii SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), mRNA K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q8TAQ2 1626 3.4e-179 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens GN=SMARCC2 PE=1 SV=1 PF07460//PF04433 NUMOD3 motif (2 copies)//SWIRM domain -- -- GO:0005515//GO:0003677//GO:0005488 protein binding//DNA binding//binding -- -- KOG1279 Chromatin remodeling factor subunit and related transcription factors Cluster-8309.41345 BF_2 757.21 12.76 2770 237681162 NP_001153726.1 932 1.5e-97 glyoxylate reductase/hydroxypyruvate reductase-like [Tribolium castaneum]>gi|270012386|gb|EFA08834.1| LOW QUALITY PROTEIN: hypothetical protein TcasGA2_TC006532 [Tribolium castaneum] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 546 3.6e-54 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF03435//PF00389//PF02826//PF03446 Saccharopine dehydrogenase NADP binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0019521//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//metabolic process//pentose-phosphate shunt GO:0005488//GO:0004616//GO:0051287//GO:0016616//GO:0016491 binding//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.41346 BF_2 1167.00 11.30 4607 91086043 XP_973506.1 3181 0.0e+00 PREDICTED: transmembrane protein 245 [Tribolium castaneum]>gi|270010191|gb|EFA06639.1| hypothetical protein TcasGA2_TC009562 [Tribolium castaneum] 752866659 XM_011271529.1 35 7.32307e-06 PREDICTED: Camponotus floridanus transmembrane protein 245 (LOC105259540), transcript variant X3, mRNA -- -- -- -- Q9H330 868 2.8e-91 Transmembrane protein 245 OS=Homo sapiens GN=TMEM245 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2365 Uncharacterized membrane protein Cluster-8309.41347 BF_2 662.23 2.72 10457 642925384 XP_008194526.1 9484 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [Tribolium castaneum] 815805023 XM_012367811.1 81 4.47872e-31 PREDICTED: Linepithema humile transcription-associated protein 1 (LOC105672707), mRNA K08874 TRRAP transformation/transcription domain-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08874 Q9Y4A5 5859 0.0e+00 Transformation/transcription domain-associated protein OS=Homo sapiens GN=TRRAP PE=1 SV=3 PF13414//PF02259//PF13181//PF04065 TPR repeat//FAT domain//Tetratricopeptide repeat//Not1 N-terminal domain, CCR4-Not complex component GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG0889 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily Cluster-8309.41348 BF_2 67.00 4.12 967 270016375 EFA12821.1 269 4.0e-21 hypothetical protein TcasGA2_TC001888 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41349 BF_2 144.55 1.02 6236 332373884 AEE62083.1 1889 3.7e-208 unknown [Dendroctonus ponderosae] 332373883 BT127121.1 228 5.1164e-113 Dendroctonus ponderosae clone DPO1140_F24 unknown mRNA K11462 EED polycomb protein EED http://www.genome.jp/dbget-bin/www_bget?ko:K11462 Q5ZKH3 1420 3.7e-155 Polycomb protein EED OS=Gallus gallus GN=EED PE=2 SV=1 PF03650//PF01435//PF00400//PF03598 Uncharacterised protein family (UPF0041)//Peptidase family M48//WD domain, G-beta repeat//CO dehydrogenase/acetyl-CoA synthase complex beta subunit GO:0006508//GO:0015947//GO:0006084//GO:0006850 proteolysis//methane metabolic process//acetyl-CoA metabolic process//mitochondrial pyruvate transport GO:0018492//GO:0004222//GO:0005515 carbon-monoxide dehydrogenase (acceptor) activity//metalloendopeptidase activity//protein binding GO:0005743 mitochondrial inner membrane KOG2719 Metalloprotease Cluster-8309.4135 BF_2 2.00 0.37 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41350 BF_2 186.76 2.06 4077 91078812 XP_970578.1 598 1.2e-58 PREDICTED: phytanoyl-CoA dioxygenase domain-containing protein 1 homolog [Tribolium castaneum]>gi|270004117|gb|EFA00565.1| hypothetical protein TcasGA2_TC003435 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SRE7 351 2.2e-31 Phytanoyl-CoA dioxygenase domain-containing protein 1 OS=Homo sapiens GN=PHYHD1 PE=1 SV=2 PF04005 Hus1-like protein GO:0000077//GO:0006281 DNA damage checkpoint//DNA repair -- -- GO:0030896 checkpoint clamp complex KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.41353 BF_2 1392.84 9.60 6356 642924384 XP_008194273.1 2890 0.0e+00 PREDICTED: WD repeat-containing protein 59 [Tribolium castaneum]>gi|270007891|gb|EFA04339.1| hypothetical protein TcasGA2_TC014633 [Tribolium castaneum] 195162816 XM_002022214.1 101 2.07012e-42 Drosophila persimilis GL24697 (Dper\GL24697), mRNA -- -- -- -- Q9VKK2 1400 7.8e-153 WD repeat-containing protein 59 homolog OS=Drosophila melanogaster GN=CG4705 PE=1 SV=3 PF00324//PF02459//PF05773//PF13520 Amino acid permease//Adenoviral DNA terminal protein//RWD domain//Amino acid permease GO:0006865//GO:0055085//GO:0006810//GO:0003333//GO:0006260 amino acid transport//transmembrane transport//transport//amino acid transmembrane transport//DNA replication GO:0003677//GO:0015171//GO:0005515 DNA binding//amino acid transmembrane transporter activity//protein binding GO:0016020 membrane -- -- Cluster-8309.41355 BF_2 93.52 0.73 5633 642927663 XP_008195354.1 1331 1.7e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.4e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.41356 BF_2 378.00 23.06 973 195453696 XP_002073900.1 1480 1.5e-161 GK14362 [Drosophila willistoni]>gi|194169985|gb|EDW84886.1| GK14362 [Drosophila willistoni] 803322942 XM_012164297.1 470 0 PREDICTED: Ovis aries musimon tubulin alpha-3 chain (LOC101108295), transcript variant X3, mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q71U36 1476 1.8e-162 Tubulin alpha-1A chain OS=Homo sapiens GN=TUBA1A PE=1 SV=1 PF00091//PF04928//PF14820//PF00706 Tubulin/FtsZ family, GTPase domain//Poly(A) polymerase central domain//Small proline-rich 2//Anenome neurotoxin GO:0043631//GO:0009966//GO:0007018//GO:0051258//GO:0006184 RNA polyadenylation//regulation of signal transduction//microtubule-based movement//protein polymerization//obsolete GTP catabolic process GO:0004652//GO:0003924//GO:0005198//GO:0005525 polynucleotide adenylyltransferase activity//GTPase activity//structural molecule activity//GTP binding GO:0005874//GO:0005576//GO:0005737//GO:0001533 microtubule//extracellular region//cytoplasm//cornified envelope KOG1376 Alpha tubulin Cluster-8309.41358 BF_2 212.61 1.65 5666 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.20795e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 Q16204 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Homo sapiens GN=CCDC6 PE=1 SV=2 PF04434//PF04647//PF04551 SWIM zinc finger//Accessory gene regulator B//GcpE protein GO:0016114//GO:0009405//GO:0055114//GO:0009372 terpenoid biosynthetic process//pathogenesis//oxidation-reduction process//quorum sensing GO:0046429//GO:0008233//GO:0008270 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//peptidase activity//zinc ion binding GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.41360 BF_2 32.45 0.37 3942 189235679 XP_971393.2 226 1.6e-15 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41361 BF_2 118.58 0.55 9336 642926973 XP_008195085.1 2249 9.9e-250 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.0e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF00621//PF06206//PF05791//PF03650//PF10186//PF08031 RhoGEF domain//CpeT/CpcT family (DUF1001)//Bacillus haemolytic enterotoxin (HBL)//Uncharacterised protein family (UPF0041)//Vacuolar sorting 38 and autophagy-related subunit 14//Berberine and berberine like GO:0010508//GO:0017009//GO:0055114//GO:0043087//GO:0006850//GO:0009405//GO:0035023 positive regulation of autophagy//protein-phycocyanobilin linkage//oxidation-reduction process//regulation of GTPase activity//mitochondrial pyruvate transport//pathogenesis//regulation of Rho protein signal transduction GO:0005089//GO:0050660//GO:0016491 Rho guanyl-nucleotide exchange factor activity//flavin adenine dinucleotide binding//oxidoreductase activity GO:0016020//GO:0005743 membrane//mitochondrial inner membrane -- -- Cluster-8309.41362 BF_2 149.94 6.20 1299 146432689 ABQ41245.1 359 2.0e-31 male reproductive-related LIM protein [Macrobrachium rosenbergii] 525346489 KC793960.1 52 7.18319e-16 Scylla paramamosain clone Scpa68 microsatellite sequence K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 262 1.4e-21 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00096//PF02150//PF00412//PF08063 Zinc finger, C2H2 type//RNA polymerases M/15 Kd subunit//LIM domain//PADR1 (NUC008) domain GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0003950//GO:0046872//GO:0008270//GO:0003899//GO:0003677 NAD+ ADP-ribosyltransferase activity//metal ion binding//zinc ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.41364 BF_2 807.18 12.02 3096 642927514 XP_008195300.1 1933 1.4e-213 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] 170047638 XM_001851269.1 219 2.54312e-108 Culex quinquefasciatus conserved hypothetical protein, mRNA K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 A1L1G1 994 4.5e-106 Epithelial splicing regulatory protein 1 OS=Danio rerio GN=esrp1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.41365 BF_2 27.42 0.69 1945 270014340 EFA10788.1 281 3.3e-22 hypothetical protein TcasGA2_TC012758 [Tribolium castaneum] -- -- -- -- -- K12384 SCARB2, LIMP2, CD36L2 lysosome membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12384 Q27367 194 1.7e-13 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF08091//PF01130 Spider insecticidal peptide//CD36 family GO:0007155//GO:0009405 cell adhesion//pathogenesis -- -- GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.41366 BF_2 147.91 3.08 2295 478250852 ENN71341.1 953 4.6e-100 hypothetical protein YQE_11956, partial [Dendroctonus ponderosae]>gi|546678340|gb|ERL88982.1| hypothetical protein D910_06360 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VPK7 555 2.7e-55 Putative tRNA pseudouridine synthase Pus10 OS=Drosophila melanogaster GN=Pus10 PE=2 SV=2 PF02058//PF01416 Guanylin precursor//tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0009982//GO:0003723//GO:0030250 pseudouridine synthase activity//RNA binding//guanylate cyclase activator activity GO:0005576 extracellular region KOG2364 Predicted pseudouridylate synthase Cluster-8309.41367 BF_2 16.67 1.20 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02096 60Kd inner membrane protein GO:0051205 protein insertion into membrane -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41370 BF_2 161.09 1.87 3896 642932512 XP_008197144.1 2807 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum]>gi|642932514|ref|XP_008197145.1| PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum] 642932517 XM_008198925.1 651 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 P32023 2359 3.0e-264 cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 OS=Drosophila melanogaster GN=for PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.41372 BF_2 12.69 1.52 636 642931959 XP_008196795.1 248 7.2e-19 PREDICTED: tRNA-splicing endonuclease subunit Sen54-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2A2 138 1.7e-07 tRNA-splicing endonuclease subunit Sen54 OS=Mus musculus GN=Tsen54 PE=2 SV=2 PF02778 tRNA intron endonuclease, N-terminal domain GO:0051252//GO:0006388 regulation of RNA metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation GO:0000213 tRNA-intron endonuclease activity GO:0000214 tRNA-intron endonuclease complex -- -- Cluster-8309.41373 BF_2 121.89 1.44 3819 270013936 EFA10384.1 2301 3.8e-256 hypothetical protein TcasGA2_TC012615 [Tribolium castaneum] 642935647 XM_008199876.1 190 4.15425e-92 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 726 6.7e-75 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.41376 BF_2 98.29 1.11 3993 642932217 XP_008194627.1 1114 1.7e-118 PREDICTED: protein spinster isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GQQ0 813 5.7e-85 Protein spinster OS=Drosophila melanogaster GN=spin PE=1 SV=1 PF03137//PF00335 Organic Anion Transporter Polypeptide (OATP) family//Tetraspanin family GO:0006810 transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1330 Sugar transporter/spinster transmembrane protein Cluster-8309.41377 BF_2 70.50 0.34 8859 642917541 XP_008191247.1 5924 0.0e+00 PREDICTED: protein TANC2 isoform X3 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.78932e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.6e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF07728//PF00097//PF13606//PF00004//PF00023//PF01637//PF02376//PF13414//PF13639 AAA domain (dynein-related subfamily)//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//ATPase family associated with various cellular activities (AAA)//Ankyrin repeat//Archaeal ATPase//CUT domain//TPR repeat//Ring finger domain -- -- GO:0046872//GO:0005515//GO:0005524//GO:0008270//GO:0003677//GO:0016887 metal ion binding//protein binding//ATP binding//zinc ion binding//DNA binding//ATPase activity -- -- -- -- Cluster-8309.41378 BF_2 2485.61 30.21 3729 91075966 XP_969306.1 1289 8.3e-139 PREDICTED: electron transfer flavoprotein subunit alpha, mitochondrial [Tribolium castaneum]>gi|270014657|gb|EFA11105.1| hypothetical protein TcasGA2_TC004703 [Tribolium castaneum] -- -- -- -- -- K03522 fixB, etfA electron transfer flavoprotein alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03522 P13803 1016 1.5e-108 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Rattus norvegicus GN=Etfa PE=1 SV=4 PF15453//PF02796//PF04218//PF03184 Protein incorporated later into Tight Junctions//Helix-turn-helix domain of resolvase//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease GO:0006310//GO:0006118 DNA recombination//obsolete electron transport GO:0003677//GO:0000150//GO:0050660//GO:0003676//GO:0009055 DNA binding//recombinase activity//flavin adenine dinucleotide binding//nucleic acid binding//electron carrier activity GO:0005923 bicellular tight junction KOG3954 Electron transfer flavoprotein, alpha subunit Cluster-8309.41380 BF_2 49.00 1.80 1423 -- -- -- -- -- 86515329 NM_001039401.1 71 2.16231e-26 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41381 BF_2 240.92 2.87 3802 -- -- -- -- -- 86515329 NM_001039401.1 63 1.64228e-21 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.41384 BF_2 3722.17 42.03 3992 642923280 XP_008193688.1 2173 2.8e-241 PREDICTED: long-chain fatty acid transport protein 4 [Tribolium castaneum] -- -- -- -- -- K08745 SLC27A1_4, FATP1, FATP4 solute carrier family 27 (fatty acid transporter), member 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K08745 Q6P1M0 1350 3.1e-147 Long-chain fatty acid transport protein 4 OS=Homo sapiens GN=SLC27A4 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1179 Very long-chain acyl-CoA synthetase/fatty acid transporter Cluster-8309.41386 BF_2 92.09 1.43 2990 270003147 EEZ99594.1 759 1.9e-77 hypothetical protein TcasGA2_TC001581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41387 BF_2 56.32 1.42 1941 641657806 XP_008180482.1 398 8.9e-36 PREDICTED: uncharacterized protein LOC103308593 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16590 Exocrine gland-secreting peptide GO:0007165 signal transduction GO:0005186 pheromone activity GO:0005615 extracellular space -- -- Cluster-8309.41388 BF_2 3392.17 37.70 4051 332373348 AEE61815.1 1592 6.6e-174 unknown [Dendroctonus ponderosae] 769840408 XM_011633076.1 188 5.70343e-91 PREDICTED: Pogonomyrmex barbatus probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (LOC105423352), transcript variant X2, mRNA K00161 PDHA, pdhA pyruvate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00161 P26268 1220 3.7e-132 Pyruvate dehydrogenase E1 component subunit alpha type II, mitochondrial (Fragment) OS=Ascaris suum PE=2 SV=1 PF02775//PF09029//PF00676//PF13292 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//5-aminolevulinate synthase presequence//Dehydrogenase E1 component//1-deoxy-D-xylulose-5-phosphate synthase GO:0006563//GO:0016114//GO:0042967//GO:0006566//GO:0006778//GO:0006694//GO:0008152//GO:0006544//GO:0006783 L-serine metabolic process//terpenoid biosynthetic process//acyl-carrier-protein biosynthetic process//threonine metabolic process//porphyrin-containing compound metabolic process//steroid biosynthetic process//metabolic process//glycine metabolic process//heme biosynthetic process GO:0008661//GO:0016624//GO:0003824//GO:0030170//GO:0003870//GO:0030976 1-deoxy-D-xylulose-5-phosphate synthase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity//pyridoxal phosphate binding//5-aminolevulinate synthase activity//thiamine pyrophosphate binding GO:0005759 mitochondrial matrix KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.41389 BF_2 753.36 18.01 2037 478250623 ENN71115.1 494 6.9e-47 hypothetical protein YQE_12048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17064 Sleepless protein GO:0030431//GO:1903818//GO:0032222 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235 GPI anchor binding -- -- -- -- Cluster-8309.41391 BF_2 29.89 0.66 2196 642919379 XP_008191847.1 1572 7.4e-172 PREDICTED: vascular endothelial growth factor receptor 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P79701 645 9.5e-66 Vascular endothelial growth factor receptor 3 OS=Coturnix coturnix GN=FLT4 PE=2 SV=1 PF13895//PF00069//PF06293//PF07714 Immunoglobulin domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0005515//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.41393 BF_2 884.00 15.73 2638 512923828 XP_004930447.1 1539 6.0e-168 PREDICTED: 25S rRNA (cytosine-C(5))-methyltransferase nop2 [Bombyx mori] -- -- -- -- -- K14835 NOP2 ribosomal RNA methyltransferase Nop2 http://www.genome.jp/dbget-bin/www_bget?ko:K14835 Q922K7 1301 9.7e-142 Probable 28S rRNA (cytosine-C(5))-methyltransferase OS=Mus musculus GN=Nop2 PE=1 SV=1 PF01189//PF01269 16S rRNA methyltransferase RsmF//Fibrillarin GO:0008033//GO:0006364 tRNA processing//rRNA processing GO:0003723//GO:0008168 RNA binding//methyltransferase activity -- -- KOG1122 tRNA and rRNA cytosine-C5-methylase (nucleolar protein NOL1/NOP2) Cluster-8309.41394 BF_2 8.97 0.55 970 646713645 KDR17927.1 356 3.3e-31 hypothetical protein L798_08003 [Zootermopsis nevadensis] -- -- -- -- -- K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 145 4.0e-08 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41395 BF_2 448.29 7.14 2913 642915738 XP_008190784.1 4283 0.0e+00 PREDICTED: kalirin isoform X3 [Tribolium castaneum] 642915737 XM_008192562.1 954 0 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X3, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 O75962 2426 3.8e-272 Triple functional domain protein OS=Homo sapiens GN=TRIO PE=1 SV=2 PF16590//PF00435//PF00018//PF14604//PF00621 Exocrine gland-secreting peptide//Spectrin repeat//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0007165//GO:0043087//GO:0035023 signal transduction//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005186//GO:0005089//GO:0005515 pheromone activity//Rho guanyl-nucleotide exchange factor activity//protein binding GO:0005615 extracellular space KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.41396 BF_2 106.60 1.22 3945 642915736 XP_008190782.1 4668 0.0e+00 PREDICTED: kalirin isoform X2 [Tribolium castaneum] 462304009 APGK01049651.1 110 1.27197e-47 Dendroctonus ponderosae Seq01049661, whole genome shotgun sequence K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q1LUA6 860 2.0e-90 Triple functional domain protein OS=Danio rerio GN=trio PE=3 SV=1 PF13895//PF00041//PF00621//PF00069//PF02899//PF07714 Immunoglobulin domain//Fibronectin type III domain//RhoGEF domain//Protein kinase domain//Phage integrase, N-terminal SAM-like domain//Protein tyrosine kinase GO:0035023//GO:0006468//GO:0043087//GO:0015074 regulation of Rho protein signal transduction//protein phosphorylation//regulation of GTPase activity//DNA integration GO:0005524//GO:0003677//GO:0005515//GO:0005089//GO:0004672 ATP binding//DNA binding//protein binding//Rho guanyl-nucleotide exchange factor activity//protein kinase activity -- -- -- -- Cluster-8309.41399 BF_2 52.38 4.96 729 189239014 XP_974755.2 558 9.4e-55 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 221 4.6e-17 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41402 BF_2 852.90 17.21 2360 642921254 XP_008192785.1 1488 4.4e-162 PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|642921256|ref|XP_008192787.1| PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|270006236|gb|EFA02684.1| hypothetical protein TcasGA2_TC008405 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q02790 1051 8.5e-113 Peptidyl-prolyl cis-trans isomerase FKBP4 OS=Homo sapiens GN=FKBP4 PE=1 SV=3 PF13181//PF13174//PF00515//PF13371//PF04434//PF13176//PF00254//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//SWIM zinc finger//Tetratricopeptide repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//TPR repeat GO:0006457 protein folding GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.41404 BF_2 2343.30 10.13 9966 642914147 XP_008201565.1 9361 0.0e+00 PREDICTED: dmX-like protein 2 [Tribolium castaneum] 642914146 XM_008203343.1 1238 0 PREDICTED: Tribolium castaneum dmX-like protein 2 (LOC660978), mRNA -- -- -- -- Q8BPN8 2323 1.1e-259 DmX-like protein 2 OS=Mus musculus GN=Dmxl2 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1064 RAVE (regulator of V-ATPase assembly) complex subunit RAV1/DMX protein, WD repeat superfamily Cluster-8309.41405 BF_2 59.22 1.07 2603 478251412 ENN71878.1 726 1.1e-73 hypothetical protein YQE_11493, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M882 217 4.8e-16 Ribonuclease P protein subunit p29 OS=Rattus norvegicus GN=Pop4 PE=2 SV=1 PF01868 Domain of unknown function UPF0086 GO:0051252//GO:0008033//GO:0006364//GO:0006379 regulation of RNA metabolic process//tRNA processing//rRNA processing//mRNA cleavage GO:0004540//GO:0003723 ribonuclease activity//RNA binding GO:0000172//GO:0030677 ribonuclease MRP complex//ribonuclease P complex KOG4046 RNase MRP and P, subunit POP4/p29 Cluster-8309.41406 BF_2 129.00 3.40 1872 642917429 XP_008191194.1 1665 1.0e-182 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P84850 1303 4.1e-142 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Rattus norvegicus GN=D2hgdh PE=3 SV=1 PF01565//PF02913 FAD binding domain//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0050660//GO:0003824 oxidoreductase activity//flavin adenine dinucleotide binding//catalytic activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.41409 BF_2 17.60 0.32 2601 642928001 XP_008195479.1 4189 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: neurexin-1 [Tribolium castaneum] 642928000 XM_008197257.1 898 0 PREDICTED: Tribolium castaneum neurexin-1 (LOC663759), mRNA K07377 NRXN neurexin http://www.genome.jp/dbget-bin/www_bget?ko:K07377 A1XQX0 1713 1.6e-189 Neurexin-1a OS=Danio rerio GN=nrxn1a PE=2 SV=1 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3514 Neurexin III-alpha Cluster-8309.41410 BF_2 267.27 4.81 2611 642913707 XP_008201129.1 453 5.0e-42 PREDICTED: trans-Golgi network integral membrane protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41411 BF_2 148.58 7.25 1144 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41412 BF_2 822.06 14.86 2602 642913707 XP_008201129.1 457 1.7e-42 PREDICTED: trans-Golgi network integral membrane protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02116 Fungal pheromone mating factor STE2 GPCR GO:0007186//GO:0019236//GO:0007606 G-protein coupled receptor signaling pathway//response to pheromone//sensory perception of chemical stimulus GO:0004932 mating-type factor pheromone receptor activity GO:0016020 membrane -- -- Cluster-8309.41413 BF_2 91.59 4.56 1127 642913445 XP_008201015.1 214 1.1e-14 PREDICTED: trypsin-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21902 148 2.1e-08 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41415 BF_2 101.31 3.83 1393 189239759 XP_001807559.1 537 4.9e-52 PREDICTED: transcription factor MafK [Tribolium castaneum]>gi|270012669|gb|EFA09117.1| hypothetical protein TcasGA2_TC015977 [Tribolium castaneum] -- -- -- -- -- K09037 MAFF_G_K transcription factor MAFF/G/K http://www.genome.jp/dbget-bin/www_bget?ko:K09037 O60675 284 4.4e-24 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 PF04111//PF03131//PF00170//PF07716//PF03404 Autophagy protein Apg6//bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper//Mo-co oxidoreductase dimerisation domain GO:0006914//GO:0055114//GO:0006355 autophagy//oxidation-reduction process//regulation of transcription, DNA-templated GO:0030151//GO:0016491//GO:0003677//GO:0003700//GO:0043565 molybdenum ion binding//oxidoreductase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.41416 BF_2 58.69 2.26 1372 189239759 XP_001807559.1 537 4.8e-52 PREDICTED: transcription factor MafK [Tribolium castaneum]>gi|270012669|gb|EFA09117.1| hypothetical protein TcasGA2_TC015977 [Tribolium castaneum] -- -- -- -- -- K09037 MAFF_G_K transcription factor MAFF/G/K http://www.genome.jp/dbget-bin/www_bget?ko:K09037 O60675 284 4.3e-24 Transcription factor MafK OS=Homo sapiens GN=MAFK PE=1 SV=1 PF03404//PF07716//PF00170//PF03131//PF04111 Mo-co oxidoreductase dimerisation domain//Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor//Autophagy protein Apg6 GO:0055114//GO:0006355//GO:0006914 oxidation-reduction process//regulation of transcription, DNA-templated//autophagy GO:0003700//GO:0043565//GO:0030151//GO:0016491//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//molybdenum ion binding//oxidoreductase activity//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.41417 BF_2 384.58 3.70 4630 270011694 EFA08142.1 1526 3.4e-166 hypothetical protein TcasGA2_TC005759 [Tribolium castaneum] 170045052 XM_001850085.1 49 1.21427e-13 Culex quinquefasciatus heparan sulfate glucosamine 3-O-sulfotransferase 3B1, mRNA K07809 HS3ST3 http://www.genome.jp/dbget-bin/www_bget?ko:K07809 Q9QZS6 961 4.6e-102 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 OS=Mus musculus GN=Hs3st3b1 PE=2 SV=2 PF00685//PF00160 Sulfotransferase domain//Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755//GO:0008146 peptidyl-prolyl cis-trans isomerase activity//sulfotransferase activity -- -- KOG3704 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase Cluster-8309.41418 BF_2 11.30 0.35 1628 642924658 XP_008194384.1 752 6.7e-77 PREDICTED: tensin isoform X10 [Tribolium castaneum] -- -- -- -- -- K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41419 BF_2 48.19 12.06 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41420 BF_2 124.88 5.95 1165 189235871 XP_001811450.1 829 5.6e-86 PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|642918227|ref|XP_008191420.1| PREDICTED: probable GPI-anchored adhesin-like protein PGA55 isoform X1 [Tribolium castaneum]>gi|270003290|gb|EEZ99737.1| hypothetical protein TcasGA2_TC002506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41423 BF_2 789.24 8.23 4298 642915716 XP_008190773.1 2335 4.9e-260 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X4 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.4e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF01920//PF00621 Prefoldin subunit//RhoGEF domain GO:0043087//GO:0035023//GO:0006457 regulation of GTPase activity//regulation of Rho protein signal transduction//protein folding GO:0005089//GO:0051082 Rho guanyl-nucleotide exchange factor activity//unfolded protein binding GO:0016272 prefoldin complex KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.41424 BF_2 119.81 12.60 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41425 BF_2 239.44 6.04 1945 642915710 XP_008190770.1 738 3.4e-75 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04992//PF01105//PF02535//PF06156 RNA polymerase Rpb1, domain 6//emp24/gp25L/p24 family/GOLD//ZIP Zinc transporter//Protein of unknown function (DUF972) GO:0006351//GO:0030001//GO:0055085//GO:0006144//GO:0006810//GO:0006206//GO:0006260 transcription, DNA-templated//metal ion transport//transmembrane transport//purine nucleobase metabolic process//transport//pyrimidine nucleobase metabolic process//DNA replication GO:0003899//GO:0003677//GO:0046873 DNA-directed RNA polymerase activity//DNA binding//metal ion transmembrane transporter activity GO:0016021//GO:0016020//GO:0005730 integral component of membrane//membrane//nucleolus -- -- Cluster-8309.41426 BF_2 1746.45 18.30 4280 91078690 XP_971137.1 2336 3.7e-260 PREDICTED: eukaryotic translation initiation factor 3 subunit L [Tribolium castaneum]>gi|270003761|gb|EFA00209.1| hypothetical protein TcasGA2_TC003034 [Tribolium castaneum] -- -- -- -- -- K15029 EIF3L translation initiation factor 3 subunit L http://www.genome.jp/dbget-bin/www_bget?ko:K15029 Q16FL6 1819 1.4e-201 Eukaryotic translation initiation factor 3 subunit L OS=Aedes aegypti GN=AAEL009617 PE=3 SV=1 PF10255//PF07668 RNA polymerase I-associated factor PAF67//M penetrans paralogue family 1 GO:0006446 regulation of translational initiation GO:0003743 translation initiation factor activity GO:0016020//GO:0005840//GO:0005737//GO:0005852 membrane//ribosome//cytoplasm//eukaryotic translation initiation factor 3 complex KOG4197 FOG: PPR repeat Cluster-8309.41427 BF_2 616.51 4.87 5587 642927663 XP_008195354.1 1331 1.7e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.4e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.41428 BF_2 872.88 10.39 3803 642928866 XP_008195596.1 3152 0.0e+00 PREDICTED: protein EFR3 homolog cmp44E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IGJ0 2001 9.5e-223 Protein EFR3 homolog cmp44E OS=Drosophila melanogaster GN=stmA PE=2 SV=3 PF07244//PF05000 Surface antigen variable number repeat//RNA polymerase Rpb1, domain 4 GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0019867//GO:0005730 outer membrane//nucleolus KOG1877 Putative transmembrane protein cmp44E Cluster-8309.41429 BF_2 357.37 38.45 676 478249910 ENN70417.1 396 5.3e-36 hypothetical protein YQE_12922, partial [Dendroctonus ponderosae]>gi|546677538|gb|ERL88357.1| hypothetical protein D910_05744 [Dendroctonus ponderosae] 195578330 XM_002078983.1 75 5.97877e-29 Drosophila simulans GD23732 (Dsim\GD23732), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41431 BF_2 138.19 1.10 5565 642926303 XP_008194869.1 1059 5.8e-112 PREDICTED: GDNF-inducible zinc finger protein 1-like [Tribolium castaneum]>gi|270008503|gb|EFA04951.1| hypothetical protein TcasGA2_TC015019 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJU3 323 5.2e-28 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13465//PF00096//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.41432 BF_2 20.53 0.50 2013 478253832 ENN74124.1 1368 3.1e-148 hypothetical protein YQE_09097, partial [Dendroctonus ponderosae]>gi|546684638|gb|ERL94255.1| hypothetical protein D910_11536 [Dendroctonus ponderosae] 749785289 XM_011148089.1 84 1.8285e-33 PREDICTED: Harpegnathos saltator probable E3 ubiquitin-protein ligase makorin-1 (LOC105187344), mRNA K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q4SRI6 727 2.7e-75 Probable E3 ubiquitin-protein ligase makorin-1 OS=Tetraodon nigroviridis GN=mkrn1 PE=3 SV=1 PF13639//PF00097//PF16954//PF14634//PF12861//PF12678//PF00642 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//Haem-transporter, endosomal/lysosomal, haem-responsive gene//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0015886//GO:0016567 heme transport//protein ubiquitination GO:0004842//GO:0005515//GO:0015232//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//heme transporter activity//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.41434 BF_2 4.00 0.34 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41436 BF_2 4.00 4.26 315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41439 BF_2 1372.81 12.58 4852 91084129 XP_969781.1 4741 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 76 1.24622e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA -- -- -- -- Q54U44 1645 2.3e-181 ABC transporter C family member 12 OS=Dictyostelium discoideum GN=abcC12 PE=3 SV=1 PF01926//PF13304//PF00664//PF08477//PF06552//PF00931//PF01637//PF02456//PF03193//PF00005 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase//Plant specific mitochondrial import receptor subunit TOM20//NB-ARC domain//Archaeal ATPase//Adenovirus IVa2 protein//Protein of unknown function, DUF258//ABC transporter GO:0007264//GO:0045040//GO:0006200//GO:0006810//GO:0055085//GO:0019083 small GTPase mediated signal transduction//protein import into mitochondrial outer membrane//obsolete ATP catabolic process//transport//transmembrane transport//viral transcription GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0043531//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ADP binding//ATP binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane -- -- Cluster-8309.41440 BF_2 380.94 3.44 4915 91084129 XP_969781.1 2413 5.0e-269 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 76 1.26252e-28 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1310 1.6e-142 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06552//PF03193//PF00005//PF02456//PF01637//PF01926//PF13304//PF00664 Plant specific mitochondrial import receptor subunit TOM20//Protein of unknown function, DUF258//ABC transporter//Adenovirus IVa2 protein//Archaeal ATPase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0009987//GO:0045040//GO:0006810//GO:0019083//GO:0055085 cellular process//protein import into mitochondrial outer membrane//transport//viral transcription//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0000166//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//nucleotide binding//GTPase activity//ATP binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane -- -- Cluster-8309.41441 BF_2 166.35 1.22 5995 827549501 XP_012546855.1 643 1.1e-63 PREDICTED: uncharacterized protein LOC101735966 [Bombyx mori] -- -- -- -- -- -- -- -- -- P35662 152 3.8e-08 Cylicin-1 OS=Bos taurus GN=CYLC1 PE=1 SV=1 PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.41443 BF_2 61.35 2.37 1372 642935257 XP_008197935.1 1283 1.5e-138 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 330 2.0e-29 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.41445 BF_2 621.99 25.95 1290 642911623 XP_008200676.1 1313 4.7e-142 PREDICTED: trypsin I-P1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21902 519 2.3e-51 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41447 BF_2 1270.69 43.65 1505 642916373 XP_008190993.1 861 1.4e-89 PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum]>gi|642916375|ref|XP_008190995.1| PREDICTED: protein lifeguard 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06890 K06890 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06890 Q7Z429 451 2.0e-43 Protein lifeguard 1 OS=Homo sapiens GN=GRINA PE=2 SV=1 PF00335//PF00032 Tetraspanin family//Cytochrome b(C-terminal)/b6/petD GO:0006118 obsolete electron transport GO:0016491//GO:0009055 oxidoreductase activity//electron carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.41448 BF_2 180.69 1.99 4091 557876145 AHA39267.1 247 6.1e-18 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02391//PF02522//PF01395 MoaE protein//Aminoglycoside 3-N-acetyltransferase//PBP/GOBP family GO:0046677//GO:0006777//GO:0042967 response to antibiotic//Mo-molybdopterin cofactor biosynthetic process//acyl-carrier-protein biosynthetic process GO:0046353//GO:0005549 aminoglycoside 3-N-acetyltransferase activity//odorant binding -- -- -- -- Cluster-8309.41449 BF_2 572.36 6.14 4188 642921291 XP_008192803.1 4509 0.0e+00 PREDICTED: disheveled-associated activator of morphogenesis 1 isoform X3 [Tribolium castaneum]>gi|270005074|gb|EFA01522.1| hypothetical protein TcasGA2_TC007082 [Tribolium castaneum] 642921290 XM_008194581.1 501 0 PREDICTED: Tribolium castaneum disheveled-associated activator of morphogenesis 1 (LOC658864), transcript variant X3, mRNA K04512 DAAM dishevelled associated activator of morphogenesis http://www.genome.jp/dbget-bin/www_bget?ko:K04512 Q8BPM0 1369 2.0e-149 Disheveled-associated activator of morphogenesis 1 OS=Mus musculus GN=Daam1 PE=1 SV=4 PF04561//PF01763//PF06367//PF06371 RNA polymerase Rpb2, domain 2//Herpesvirus UL6 like//Diaphanous FH3 Domain//Diaphanous GTPase-binding Domain GO:0006351//GO:0016043//GO:0006144//GO:0006206//GO:0030036//GO:0006323 transcription, DNA-templated//cellular component organization//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//actin cytoskeleton organization//DNA packaging GO:0003677//GO:0003899//GO:0003779//GO:0017048 DNA binding//DNA-directed RNA polymerase activity//actin binding//Rho GTPase binding GO:0005730 nucleolus KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.41450 BF_2 82.40 0.52 6980 270004791 EFA01239.1 3278 0.0e+00 hypothetical protein TcasGA2_TC000086 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61555 1031 5.2e-110 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.41451 BF_2 167.00 7.54 1214 91081381 XP_972215.1 907 5.3e-95 PREDICTED: ribose-5-phosphate isomerase [Tribolium castaneum]>gi|270005180|gb|EFA01628.1| hypothetical protein TcasGA2_TC007198 [Tribolium castaneum] -- -- -- -- -- K01807 rpiA ribose 5-phosphate isomerase A http://www.genome.jp/dbget-bin/www_bget?ko:K01807 P49247 790 8.0e-83 Ribose-5-phosphate isomerase OS=Homo sapiens GN=RPIA PE=1 SV=3 PF06026//PF04152 Ribose 5-phosphate isomerase A (phosphoriboisomerase A)//Mre11 DNA-binding presumed domain GO:0006098//GO:0006302//GO:0015976//GO:0009052 pentose-phosphate shunt//double-strand break repair//carbon utilization//pentose-phosphate shunt, non-oxidative branch GO:0004751//GO:0030145//GO:0004519 ribose-5-phosphate isomerase activity//manganese ion binding//endonuclease activity GO:0005634 nucleus KOG3075 Ribose 5-phosphate isomerase Cluster-8309.41452 BF_2 1274.33 16.18 3581 91077414 XP_975386.1 1918 9.2e-212 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 4.6e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF12634//PF00516//PF06723//PF02782//PF13414//PF15281 Inheritance of peroxisomes protein 1//Envelope glycoprotein GP120//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain//TPR repeat//Consortin C-terminus GO:0005975//GO:0045033//GO:0000902//GO:0042998//GO:0006457 carbohydrate metabolic process//peroxisome inheritance//cell morphogenesis//positive regulation of Golgi to plasma membrane protein transport//protein folding GO:0016773//GO:0051082//GO:0005515//GO:0071253//GO:0005524 phosphotransferase activity, alcohol group as acceptor//unfolded protein binding//protein binding//connexin binding//ATP binding GO:0005802//GO:0019031//GO:0005780 trans-Golgi network//viral envelope//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.41453 BF_2 961.00 10.95 3957 642938608 XP_008199863.1 2835 0.0e+00 PREDICTED: semaphorin-5A [Tribolium castaneum] -- -- -- -- -- K06841 SEMA5 semaphorin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K06841 Q60519 1711 4.2e-189 Semaphorin-5B OS=Mus musculus GN=Sema5b PE=2 SV=2 PF04850//PF01403 Baculovirus E66 occlusion-derived virus envelope protein//Sema domain -- -- GO:0005515 protein binding GO:0019031 viral envelope -- -- Cluster-8309.41454 BF_2 1430.24 18.81 3468 642929255 XP_008195756.1 2075 5.5e-230 PREDICTED: PX domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270009666|gb|EFA06114.1| hypothetical protein TcasGA2_TC008957 [Tribolium castaneum] -- -- -- -- -- K17543 PXK PX domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17543 Q7Z7A4 1138 1.0e-122 PX domain-containing protein kinase-like protein OS=Homo sapiens GN=PXK PE=1 SV=1 PF02285//PF02205//PF07714//PF02569//PF00787//PF00069 Cytochrome oxidase c subunit VIII//WH2 motif//Protein tyrosine kinase//Pantoate-beta-alanine ligase//PX domain//Protein kinase domain GO:0019482//GO:0015992//GO:0007154//GO:0006123//GO:0015940//GO:0006468 beta-alanine metabolic process//proton transport//cell communication//mitochondrial electron transport, cytochrome c to oxygen//pantothenate biosynthetic process//protein phosphorylation GO:0004592//GO:0004129//GO:0004672//GO:0005524//GO:0003779//GO:0035091 pantoate-beta-alanine ligase activity//cytochrome-c oxidase activity//protein kinase activity//ATP binding//actin binding//phosphatidylinositol binding GO:0045277 respiratory chain complex IV KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.41456 BF_2 3749.55 33.73 4937 189237669 XP_967427.2 2476 2.5e-276 PREDICTED: hypoxia-inducible factor 1-alpha [Tribolium castaneum] -- -- -- -- -- K08268 HIF1A hypoxia-inducible factor 1 alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08268 Q24167 843 2.3e-88 Protein similar OS=Drosophila melanogaster GN=sima PE=1 SV=2 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3558 Hypoxia-inducible factor 1/Neuronal PAS domain protein NPAS1 Cluster-8309.41457 BF_2 364.63 3.33 4862 -- -- -- -- -- 86515329 NM_001039401.1 63 2.10453e-21 Tribolium castaneum pangolin (Pan), mRNA >gnl|BL_ORD_ID|637993 Tribolium castaneum pangolin mRNA, complete cds -- -- -- -- -- -- -- -- PF00404 Dockerin type I repeat GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.41458 BF_2 780.63 6.89 5026 546673034 ERL84720.1 3183 0.0e+00 hypothetical protein D910_02145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 1695 3.8e-187 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 PF06529 Vertebrate interleukin-3 regulated transcription factor GO:0007623//GO:0006351 circadian rhythm//transcription, DNA-templated -- -- GO:0005634 nucleus KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.41459 BF_2 26.03 0.84 1587 91086225 XP_972341.1 1458 8.9e-159 PREDICTED: dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B [Tribolium castaneum]>gi|270009866|gb|EFA06314.1| hypothetical protein TcasGA2_TC009183 [Tribolium castaneum] 820970777 XM_004634227.2 194 1.01882e-94 PREDICTED: Octodon degus STT3B, subunit of the oligosaccharyltransferase complex (catalytic) (Stt3b), mRNA K07151 STT3 dolichyl-diphosphooligosaccharide--protein glycosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07151 Q8TCJ2 1163 5.9e-126 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B OS=Homo sapiens GN=STT3B PE=1 SV=1 PF02516 Oligosaccharyl transferase STT3 subunit GO:0006486 protein glycosylation GO:0004576 oligosaccharyl transferase activity GO:0008250//GO:0016020 oligosaccharyltransferase complex//membrane KOG2292 Oligosaccharyltransferase, STT3 subunit Cluster-8309.4146 BF_2 6.00 0.41 898 161661033 ABX75383.1 682 4.8e-69 60S ribosomal protein L6 [Lycosa singoriensis] -- -- -- -- -- K02934 RP-L6e, RPL6 large subunit ribosomal protein L6e http://www.genome.jp/dbget-bin/www_bget?ko:K02934 Q6QMZ4 595 2.4e-60 60S ribosomal protein L6 OS=Chinchilla lanigera GN=RPL6 PE=2 SV=3 PF01159//PF03868 Ribosomal protein L6e//Ribosomal protein L6, N-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1694 60s ribosomal protein L6 Cluster-8309.41460 BF_2 60.62 0.69 3989 755930004 XP_011312621.1 2447 4.7e-273 PREDICTED: multidrug resistance-associated protein 4-like [Fopius arisanus] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1117 3.2e-120 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00005//PF03193//PF00664//PF13304//PF01926 ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0005525//GO:0016887 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.41462 BF_2 25.00 1.44 1011 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41465 BF_2 354.68 2.77 5642 642914563 XP_008201731.1 4144 0.0e+00 PREDICTED: histone-lysine N-methyltransferase ash1 isoform X2 [Tribolium castaneum]>gi|270001477|gb|EEZ97924.1| hypothetical protein TcasGA2_TC000311 [Tribolium castaneum] -- -- -- -- -- K06101 ASH1L histone-lysine N-methyltransferase ASH1L http://www.genome.jp/dbget-bin/www_bget?ko:K06101 Q9VW15 1058 3.1e-113 Histone-lysine N-methyltransferase ash1 OS=Drosophila melanogaster GN=ash1 PE=1 SV=3 PF00439//PF00856//PF01426//PF02378//PF00628 Bromodomain//SET domain//BAH domain//Phosphotransferase system, EIIC//PHD-finger GO:0009401//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0008982//GO:0005488//GO:0003682//GO:0016740//GO:0005515 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//binding//chromatin binding//transferase activity//protein binding GO:0009357//GO:0016020//GO:0000785 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane//chromatin KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.41467 BF_2 10.59 0.36 1510 478254782 ENN75018.1 768 8.7e-79 hypothetical protein YQE_08333, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BTX7 163 5.1e-10 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41469 BF_2 689.03 3.45 8635 270297218 NP_001161918.1 773 1.3e-78 cuticular protein analogous to peritrophins 1-H precursor [Tribolium castaneum]>gi|642929138|ref|XP_008195708.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|642929140|ref|XP_008195709.1| PREDICTED: cuticular protein analogous to peritrophins 1-H isoform X1 [Tribolium castaneum]>gi|268309014|gb|ACY95473.1| cuticular protein analogous to peritrophins 1-H [Tribolium castaneum]>gi|270010495|gb|EFA06943.1| hypothetical protein TcasGA2_TC009894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07827//PF01607 KNTase C-terminal domain//Chitin binding Peritrophin-A domain GO:0006030//GO:0046677 chitin metabolic process//response to antibiotic GO:0016779//GO:0008061 nucleotidyltransferase activity//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.41473 BF_2 175.35 1.35 5732 642929442 XP_008195842.1 5299 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X3 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 4034 0.0e+00 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00312//PF00520//PF16519 Ribosomal protein S15//Ion transport protein//Tetramerisation domain of TRPM GO:0006811//GO:0042254//GO:0055085//GO:0051262//GO:0006412 ion transport//ribosome biogenesis//transmembrane transport//protein tetramerization//translation GO:0005216//GO:0003735 ion channel activity//structural constituent of ribosome GO:0005622//GO:0016020//GO:0005840 intracellular//membrane//ribosome KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.41474 BF_2 344.45 1.58 9379 642926040 XP_008194740.1 10464 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 1035 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 7579 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF02655//PF02786//PF07478//PF08326 ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//Acetyl-CoA carboxylase, central region GO:0046436//GO:0006633//GO:0009252//GO:0006090 D-alanine metabolic process//fatty acid biosynthetic process//peptidoglycan biosynthetic process//pyruvate metabolic process GO:0005524//GO:0003989//GO:0008716//GO:0046872 ATP binding//acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity//metal ion binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.41475 BF_2 174.17 1.23 6203 642926044 XP_008194742.1 8497 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X3 [Tribolium castaneum] 827556928 XM_012694321.1 547 0 PREDICTED: Bombyx mori acetyl-CoA carboxylase (LOC101738903), transcript variant X3, mRNA K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 6090 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF08326 Acetyl-CoA carboxylase, central region GO:0006633//GO:0006090 fatty acid biosynthetic process//pyruvate metabolic process GO:0003989//GO:0005524 acetyl-CoA carboxylase activity//ATP binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.41476 BF_2 371.48 5.67 3028 642919702 XP_008192028.1 2244 1.2e-249 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 900 3.5e-95 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.41478 BF_2 681.90 11.48 2772 478250432 ENN70927.1 576 2.9e-56 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] 645036882 XM_001607897.2 186 5.0276e-90 PREDICTED: Nasonia vitripennis histone H2A-like (LOC100114644), mRNA K11251 H2A histone H2A http://www.genome.jp/dbget-bin/www_bget?ko:K11251 P84054 471 1.8e-45 Histone H2A OS=Drosophila simulans GN=His2A PE=3 SV=2 PF12513//PF00125//PF00656 Mitochondrial degradasome RNA helicase subunit C terminal//Core histone H2A/H2B/H3/H4//Caspase domain GO:0006508 proteolysis GO:0004197//GO:0016817//GO:0003677 cysteine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//DNA binding -- -- -- -- Cluster-8309.41479 BF_2 3196.92 49.37 2996 642930314 XP_008196343.1 1168 7.1e-125 PREDICTED: UDP-glucuronosyltransferase 2B17-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 447 1.2e-42 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.41481 BF_2 305.85 2.50 5412 270011060 EFA07508.1 3836 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1227 7.6e-133 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF07678//PF07677//PF01835//PF01483//PF00207 A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain//Proprotein convertase P-domain//Alpha-2-macroglobulin family GO:0006508 proteolysis GO:0004866//GO:0004252 endopeptidase inhibitor activity//serine-type endopeptidase activity GO:0005576//GO:0005615 extracellular region//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.41482 BF_2 1175.82 18.13 3000 478257576 ENN77730.1 2406 2.0e-268 hypothetical protein YQE_05801, partial [Dendroctonus ponderosae] -- -- -- -- -- K12261 HACL1 2-hydroxyacyl-CoA lyase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12261 Q9UJ83 1577 1.1e-173 2-hydroxyacyl-CoA lyase 1 OS=Homo sapiens GN=HACL1 PE=1 SV=2 PF00205//PF02775//PF02776//PF02552 Thiamine pyrophosphate enzyme, central domain//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//Thiamine pyrophosphate enzyme, N-terminal TPP binding domain//CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit GO:0019385 methanogenesis, from acetate GO:0000287//GO:0030976//GO:0003824 magnesium ion binding//thiamine pyrophosphate binding//catalytic activity -- -- KOG1185 Thiamine pyrophosphate-requiring enzyme Cluster-8309.41483 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41484 BF_2 672.00 20.55 1655 642922490 XP_008193193.1 963 2.3e-101 PREDICTED: protein big brother-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24040 770 2.3e-80 Protein big brother OS=Drosophila melanogaster GN=Bgb PE=2 SV=3 PF02312 Core binding factor beta subunit -- -- GO:0003713 transcription coactivator activity GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.41485 BF_2 52.76 0.89 2779 546685202 ERL94729.1 1287 1.0e-138 hypothetical protein D910_12003 [Dendroctonus ponderosae] -- -- -- -- -- K08860 EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08860 Q9NIV1 568 1.0e-56 Eukaryotic translation initiation factor 2-alpha kinase OS=Drosophila melanogaster GN=PEK PE=1 SV=2 PF06293//PF00069//PF07714//PF10588 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114//GO:0006468 oxidation-reduction process//protein phosphorylation GO:0016491//GO:0004672//GO:0005524//GO:0016773 oxidoreductase activity//protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG1035 eIF-2alpha kinase GCN2 Cluster-8309.41486 BF_2 1054.82 12.83 3726 642931768 XP_008196720.1 1923 2.5e-212 PREDICTED: cytohesin-1 isoform X3 [Tribolium castaneum] 676429235 XM_009047286.1 185 2.43875e-89 Lottia gigantea hypothetical protein partial mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 1356 5.8e-148 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.41487 BF_2 28.41 0.35 3701 642931770 XP_008196721.1 1314 1.0e-141 PREDICTED: cytohesin-1 isoform X4 [Tribolium castaneum] 749754538 XM_011141408.1 144 1.49965e-66 PREDICTED: Harpegnathos saltator cytohesin-1-like (LOC105183356), transcript variant X2, mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 980 2.3e-104 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.41488 BF_2 49.21 0.64 3484 665810054 XP_008553427.1 1656 2.1e-181 PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|665810056|ref|XP_008553428.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|751201535|ref|XP_011167836.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Solenopsis invicta]>gi|780681748|ref|XP_011697692.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Wasmannia auropunctata]>gi|795064613|ref|XP_011874023.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Vollenhovia emeryi]>gi|826425920|ref|XP_012527326.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Monomorium pharaonis] 642933469 XM_968453.3 436 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (LOC662352), mRNA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 P62716 1626 2.7e-179 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Rattus norvegicus GN=Ppp2cb PE=2 SV=1 PF09494//PF02135//PF01086//PF00149 Slx4 endonuclease//TAZ zinc finger//Clathrin light chain//Calcineurin-like phosphoesterase GO:0016192//GO:0042967//GO:0006281//GO:0006886//GO:0006355//GO:0006260//GO:0006308 vesicle-mediated transport//acyl-carrier-protein biosynthetic process//DNA repair//intracellular protein transport//regulation of transcription, DNA-templated//DNA replication//DNA catabolic process GO:0017108//GO:0005198//GO:0016787//GO:0008270//GO:0003712//GO:0004402 5'-flap endonuclease activity//structural molecule activity//hydrolase activity//zinc ion binding//transcription cofactor activity//histone acetyltransferase activity GO:0030132//GO:0030130//GO:0005667//GO:0005634//GO:0033557//GO:0000123 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle//transcription factor complex//nucleus//Slx1-Slx4 complex//histone acetyltransferase complex KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-8309.41489 BF_2 402.78 5.20 3527 91090364 XP_968231.1 1218 1.3e-130 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 509 9.0e-50 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 PF11789//PF13639//PF02891//PF14634//PF00097 Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//MIZ/SP-RING zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.41490 BF_2 642.47 2.04 13468 270007741 EFA04189.1 1783 1.6e-195 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 8.62628e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 868 8.1e-91 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF01426//PF13465//PF07975//PF00412//PF00641//PF09182//PF13912//PF02845//PF08273//PF00096//PF05495//PF07776 BAH domain//Zinc-finger double domain//TFIIH C1-like domain//LIM domain//Zn-finger in Ran binding protein and others//Bacterial purine repressor, N-terminal//C2H2-type zinc finger//CUE domain//Zinc-binding domain of primase-helicase//Zinc finger, C2H2 type//CHY zinc finger//Zinc-finger associated domain (zf-AD) GO:0006355//GO:0006269//GO:0006351//GO:0006281 regulation of transcription, DNA-templated//DNA replication, synthesis of RNA primer//transcription, DNA-templated//DNA repair GO:0008270//GO:0003682//GO:0046872//GO:0004386//GO:0003896//GO:0003677//GO:0005515 zinc ion binding//chromatin binding//metal ion binding//helicase activity//DNA primase activity//DNA binding//protein binding GO:0005730//GO:0000785//GO:0005657//GO:0005634 nucleolus//chromatin//replication fork//nucleus -- -- Cluster-8309.41491 BF_2 108.98 1.01 4791 746838316 XP_011049678.1 1675 1.8e-183 PREDICTED: uncharacterized protein LOC105143221 isoform X1 [Acromyrmex echinatior]>gi|332028468|gb|EGI68511.1| Monocarboxylate transporter 14 [Acromyrmex echinatior] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 447 1.9e-42 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF07690//PF02472//PF12537 Sugar (and other) transporter//Major Facilitator Superfamily//Biopolymer transport protein ExbD/TolR//The Golgi pH Regulator (GPHR) Family N-terminal GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.41493 BF_2 555.00 49.63 755 350646336 CCD58989.1 228 1.8e-16 hypothetical protein Smp_108010 [Schistosoma mansoni]>gi|350646338|emb|CCD58991.1| hypothetical protein Smp_100450 [Schistosoma mansoni]>gi|350646340|emb|CCD58993.1| hypothetical protein Smp_116960 [Schistosoma mansoni]>gi|353232702|emb|CCD80057.1| hypothetical protein Smp_107750 [Schistosoma mansoni] 54124688 AY620924.1 516 0 Prodinychus sp. AL7170 18S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41497 BF_2 1068.99 5.47 8459 642915855 XP_008196222.1 3032 0.0e+00 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X2 [Tribolium castaneum] 642915388 XM_008192374.1 178 4.3321e-85 PREDICTED: Tribolium castaneum uncharacterized LOC100141615 (LOC100141615), transcript variant X2, mRNA K16343 PLA2G6, IPLA2 calcium-independent phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K16343 O60733 1322 1.1e-143 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens GN=PLA2G6 PE=1 SV=2 PF01734//PF13606//PF00023 Patatin-like phospholipase//Ankyrin repeat//Ankyrin repeat GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.41498 BF_2 396.90 2.00 8603 642915855 XP_008196222.1 3032 0.0e+00 PREDICTED: 85/88 kDa calcium-independent phospholipase A2 isoform X2 [Tribolium castaneum] 642915388 XM_008192374.1 179 1.22508e-85 PREDICTED: Tribolium castaneum uncharacterized LOC100141615 (LOC100141615), transcript variant X2, mRNA K16343 PLA2G6, IPLA2 calcium-independent phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K16343 O60733 1322 1.2e-143 85/88 kDa calcium-independent phospholipase A2 OS=Homo sapiens GN=PLA2G6 PE=1 SV=2 PF13606//PF01734//PF00023//PF00320 Ankyrin repeat//Patatin-like phospholipase//Ankyrin repeat//GATA zinc finger GO:0006355//GO:0006629 regulation of transcription, DNA-templated//lipid metabolic process GO:0043565//GO:0008270//GO:0005515//GO:0003700 sequence-specific DNA binding//zinc ion binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.41502 BF_2 1163.89 22.14 2486 147902182 NP_001079763.1 447 2.4e-41 ER lumen protein-retaining receptor 3 [Xenopus laevis]>gi|6685399|sp|O42580.1|ERD23_XENLA RecName: Full=ER lumen protein-retaining receptor 3; AltName: Full=KDEL endoplasmic reticulum protein retention receptor 3; Short=KDEL receptor 3 [Xenopus laevis]>gi|2467290|emb|CAA04817.1| KDEL receptor [Xenopus laevis]>gi|32450093|gb|AAH54181.1| MGC64313 protein [Xenopus laevis] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 Q66JF2 456 8.8e-44 ER lumen protein-retaining receptor 3 OS=Xenopus tropicalis GN=kdelr3 PE=2 SV=1 PF00810//PF15050//PF05297 ER lumen protein retaining receptor//SCIMP protein//Herpesvirus latent membrane protein 1 (LMP1) GO:0019087//GO:0006621 transformation of host cell by virus//protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0097197//GO:0005783//GO:0001772//GO:0016021 tetraspanin-enriched microdomain//endoplasmic reticulum//immunological synapse//integral component of membrane KOG3106 ER lumen protein retaining receptor Cluster-8309.41503 BF_2 283.93 0.70 17236 642913486 XP_008201031.1 6078 0.0e+00 PREDICTED: histone-lysine N-methyltransferase 2C-like isoform X2 [Tribolium castaneum] 662203306 XM_008476764.1 101 5.63234e-42 PREDICTED: Diaphorina citri histone-lysine N-methyltransferase trr-like (LOC103512007), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1336 5.6e-145 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF05964//PF00628//PF07155//PF05965//PF00856 F/Y-rich N-terminus//PHD-finger//ECF-type riboflavin transporter, S component//F/Y rich C-terminus//SET domain -- -- GO:0005515 protein binding GO:0005634//GO:0016020 nucleus//membrane KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.41504 BF_2 742.62 5.04 6450 270014159 EFA10607.1 893 1.2e-92 hypothetical protein TcasGA2_TC012868 [Tribolium castaneum] 642936629 XM_008200293.1 231 1.13712e-114 PREDICTED: Tribolium castaneum serine-arginine protein 55-like (LOC660636), mRNA K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 732 2.3e-75 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00102//PF08777//PF04179//PF16367//PF00076//PF01416//PF00782//PF01529//PF02868 Protein-tyrosine phosphatase//RNA binding motif//Initiator tRNA phosphoribosyl transferase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA pseudouridine synthase//Dual specificity phosphatase, catalytic domain//DHHC palmitoyltransferase//Thermolysin metallopeptidase, alpha-helical domain GO:0019988//GO:0006570//GO:0006470//GO:0009451//GO:0001522 charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation//RNA modification//pseudouridine synthesis GO:0004222//GO:0003723//GO:0043399//GO:0008138//GO:0004725//GO:0008270//GO:0003676//GO:0009982 metalloendopeptidase activity//RNA binding//tRNA A64-2'-O-ribosylphosphate transferase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//zinc ion binding//nucleic acid binding//pseudouridine synthase activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.41506 BF_2 18.18 0.31 2719 642937320 XP_008198786.1 1165 1.4e-124 PREDICTED: venom carboxylesterase-6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B2D0J5 863 6.2e-91 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.41508 BF_2 121.00 1.15 4676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41510 BF_2 1633.03 22.33 3347 642918336 XP_008196857.1 2258 3.2e-251 PREDICTED: serine/threonine-protein kinase tricorner [Tribolium castaneum] 752860508 XM_011253959.1 362 0 PREDICTED: Camponotus floridanus serine/threonine-protein kinase tricorner (LOC105248897), transcript variant X2, mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q2LZZ7 2013 3.4e-224 Serine/threonine-protein kinase tricorner OS=Drosophila pseudoobscura pseudoobscura GN=trc PE=3 SV=1 PF00069//PF06293//PF00433//PF07714//PF04998 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//Protein tyrosine kinase//RNA polymerase Rpb1, domain 5 GO:0006351//GO:0016310//GO:0006468//GO:0006144//GO:0009069//GO:0006206 transcription, DNA-templated//phosphorylation//protein phosphorylation//purine nucleobase metabolic process//serine family amino acid metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005524//GO:0016773//GO:0004674//GO:0004672 DNA binding//DNA-directed RNA polymerase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein serine/threonine kinase activity//protein kinase activity GO:0016020//GO:0005730 membrane//nucleolus KOG0605 NDR and related serine/threonine kinases Cluster-8309.41512 BF_2 233.00 4.37 2517 642936089 XP_008198299.1 3648 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 2 [Tribolium castaneum]>gi|270013200|gb|EFA09648.1| hypothetical protein TcasGA2_TC011774 [Tribolium castaneum] 752890085 XM_011264720.1 314 3.19429e-161 PREDICTED: Camponotus floridanus transcription initiation factor TFIID subunit 2 (LOC105255436), mRNA K03128 TAF2 transcription initiation factor TFIID subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03128 Q24325 2774 1.6e-312 Transcription initiation factor TFIID subunit 2 OS=Drosophila melanogaster GN=Taf2 PE=1 SV=2 PF01433 Peptidase family M1 GO:0032259 methylation GO:0003676//GO:0008237//GO:0008270//GO:0008168//GO:0004222 nucleic acid binding//metallopeptidase activity//zinc ion binding//methyltransferase activity//metalloendopeptidase activity -- -- KOG1932 TATA binding protein associated factor Cluster-8309.41515 BF_2 3.64 0.73 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41516 BF_2 3097.43 19.26 7014 546685725 ERL95180.1 4209 0.0e+00 hypothetical protein D910_12448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.5e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.41517 BF_2 1663.65 30.25 2588 91081621 XP_966892.1 1552 1.8e-169 PREDICTED: probable 4-coumarate--CoA ligase 1 [Tribolium castaneum]>gi|270005089|gb|EFA01537.1| hypothetical protein TcasGA2_TC007097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O24145 893 2.0e-94 4-coumarate--CoA ligase 1 OS=Nicotiana tabacum GN=4CL1 PE=2 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.41518 BF_2 771.88 5.44 6222 270013964 EFA10412.1 5274 0.0e+00 hypothetical protein TcasGA2_TC012652 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 O15013 1221 4.3e-132 Rho guanine nucleotide exchange factor 10 OS=Homo sapiens GN=ARHGEF10 PE=1 SV=4 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.41519 BF_2 123.75 3.96 1593 642927970 XP_972030.2 1040 2.6e-110 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q80Z70 530 1.5e-52 Protein sel-1 homolog 1 OS=Rattus norvegicus GN=Sel1l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.4152 BF_2 2.00 0.50 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41520 BF_2 371.46 16.07 1254 642927970 XP_972030.2 1037 4.6e-110 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] -- -- -- -- -- K14026 SEL1, SEL1L SEL1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14026 Q80Z70 530 1.2e-52 Protein sel-1 homolog 1 OS=Rattus norvegicus GN=Sel1l PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1550 Extracellular protein SEL-1 and related proteins Cluster-8309.41526 BF_2 135.69 4.22 1631 642918353 XP_008199964.1 155 1.1e-07 PREDICTED: LOW QUALITY PROTEIN: rap guanine nucleotide exchange factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41527 BF_2 1446.35 17.26 3792 332376073 AEE63177.1 2232 3.8e-248 unknown [Dendroctonus ponderosae] 751798911 XM_011211092.1 84 3.47102e-33 PREDICTED: Bactrocera dorsalis probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial (LOC105230362), mRNA K00140 mmsA, iolA, ALDH6A1 malonate-semialdehyde dehydrogenase (acetylating) / methylmalonate-semialdehyde dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00140 Q17M80 1920 2.3e-213 Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Aedes aegypti GN=AAEL001134 PE=3 SV=1 PF00171//PF05893 Aldehyde dehydrogenase family//Acyl-CoA reductase (LuxC) GO:0008218//GO:0055114//GO:0006118//GO:0008152 bioluminescence//oxidation-reduction process//obsolete electron transport//metabolic process GO:0016491//GO:0003995 oxidoreductase activity//acyl-CoA dehydrogenase activity -- -- KOG2449 Methylmalonate semialdehyde dehydrogenase Cluster-8309.41529 BF_2 97.26 0.52 8150 546681997 ERL91993.1 4107 0.0e+00 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 2242 2.3e-250 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF09026//PF05456//PF06701 Centromere protein B dimerisation domain//Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)//Mib_herc2 GO:0016567//GO:0045947//GO:0006355 protein ubiquitination//negative regulation of translational initiation//regulation of transcription, DNA-templated GO:0004842//GO:0003677//GO:0008190//GO:0003682//GO:0046872 ubiquitin-protein transferase activity//DNA binding//eukaryotic initiation factor 4E binding//chromatin binding//metal ion binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region KOG4276 Predicted hormone receptor interactor Cluster-8309.41530 BF_2 61.61 0.88 3201 270004099 EFA00547.1 889 1.7e-92 hypothetical protein TcasGA2_TC003413 [Tribolium castaneum] 442633737 NM_176374.2 162 1.27686e-76 Drosophila melanogaster knirps-like (knrl), mRNA K08706 NR0AN, kni nuclear receptor subfamily 0 group A http://www.genome.jp/dbget-bin/www_bget?ko:K08706 P13054 507 1.4e-49 Knirps-related protein OS=Drosophila melanogaster GN=knrl PE=2 SV=1 PF05337//PF00105//PF00645 Macrophage colony stimulating factor-1 (CSF-1)//Zinc finger, C4 type (two domains)//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0040007//GO:0007165//GO:0008283//GO:0006355 growth//signal transduction//cell proliferation//regulation of transcription, DNA-templated GO:0008083//GO:0003677//GO:0008270//GO:0043565//GO:0005125//GO:0003700 growth factor activity//DNA binding//zinc ion binding//sequence-specific DNA binding//cytokine activity//transcription factor activity, sequence-specific DNA binding GO:0016021//GO:0005634//GO:0005667 integral component of membrane//nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.41531 BF_2 593.58 6.39 4171 642918310 XP_008191453.1 4172 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 2.3e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.41532 BF_2 2712.19 106.75 1350 642934210 XP_967287.2 215 1.0e-14 PREDICTED: uncharacterized protein C34C12.4 [Tribolium castaneum]>gi|270012965|gb|EFA09413.1| hypothetical protein TcasGA2_TC005215 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91VT8 174 2.4e-11 Small integral membrane protein 14 OS=Mus musculus GN=Smim14 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41534 BF_2 827.21 6.91 5297 546673559 ERL85134.1 861 5.0e-89 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41535 BF_2 668.12 20.74 1635 546673559 ERL85134.1 400 4.4e-36 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41536 BF_2 93.27 0.65 6278 478251857 ENN72296.1 1149 2.4e-122 hypothetical protein YQE_11039, partial [Dendroctonus ponderosae]>gi|546673558|gb|ERL85133.1| hypothetical protein D910_02555 [Dendroctonus ponderosae] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 Q5ZLN1 818 2.4e-85 Phosphoglycerate mutase 1 OS=Gallus gallus GN=PGAM1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.41538 BF_2 446.33 3.08 6351 642915800 XP_008200083.1 3469 0.0e+00 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum] -- -- -- -- -- K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q62371 723 2.5e-74 Discoidin domain-containing receptor 2 OS=Mus musculus GN=Ddr2 PE=1 SV=2 PF09472//PF00069//PF07714 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Protein kinase domain//Protein tyrosine kinase GO:0015948//GO:0046656//GO:0006468 methanogenesis//folic acid biosynthetic process//protein phosphorylation GO:0030269//GO:0005524//GO:0004672 tetrahydromethanopterin S-methyltransferase activity//ATP binding//protein kinase activity GO:0016020 membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.41539 BF_2 83.35 0.43 8404 642919073 XP_008191722.1 1583 1.5e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.5e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.41541 BF_2 82.50 3.63 1237 861599125 KMQ83546.1 410 2.3e-37 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16685 zinc RING finger of MSL2 -- -- GO:0061630 ubiquitin protein ligase activity -- -- -- -- Cluster-8309.41542 BF_2 34.00 4.71 589 607353959 EZA48640.1 163 4.8e-09 hypothetical protein X777_13603 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41543 BF_2 777.56 7.62 4558 91084835 XP_966560.1 1369 5.3e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 6.5e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00892//PF13895//PF08449//PF04142//PF06027//PF00893//PF00114 EamA-like transporter family//Immunoglobulin domain//UAA transporter family//Nucleotide-sugar transporter//Solute carrier family 35//Small Multidrug Resistance protein//Pilin (bacterial filament) GO:0055085//GO:0006810//GO:0007155//GO:0008643 transmembrane transport//transport//cell adhesion//carbohydrate transport GO:0005351//GO:0005515 sugar:proton symporter activity//protein binding GO:0009289//GO:0016021//GO:0000139//GO:0016020 pilus//integral component of membrane//Golgi membrane//membrane KOG3912 Predicted integral membrane protein Cluster-8309.41544 BF_2 161.49 2.15 3423 91084835 XP_966560.1 1369 4.0e-148 PREDICTED: solute carrier family 35 member F6 [Tribolium castaneum]>gi|270008579|gb|EFA05027.1| hypothetical protein TcasGA2_TC015114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N357 744 4.9e-77 Solute carrier family 35 member F6 OS=Homo sapiens GN=SLC35F6 PE=1 SV=1 PF00892//PF06027//PF08449//PF04142//PF00893 EamA-like transporter family//Solute carrier family 35//UAA transporter family//Nucleotide-sugar transporter//Small Multidrug Resistance protein GO:0055085//GO:0008643//GO:0006810 transmembrane transport//carbohydrate transport//transport GO:0005351 sugar:proton symporter activity GO:0016020//GO:0000139//GO:0016021 membrane//Golgi membrane//integral component of membrane KOG3912 Predicted integral membrane protein Cluster-8309.41548 BF_2 62.98 0.32 8394 642919607 XP_008191937.1 1817 1.1e-199 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X1 [Tribolium castaneum] 642919610 XM_970305.3 84 7.72051e-33 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X3, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 355 1.5e-31 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF04177//PF02257//PF12031 TAP42-like family//RFX DNA-binding domain//Domain of unknown function (DUF3518) GO:0009966//GO:0006355//GO:0006338 regulation of signal transduction//regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.41549 BF_2 266.28 1.85 6292 91086811 XP_973640.1 3020 0.0e+00 PREDICTED: tetratricopeptide repeat protein 30A [Tribolium castaneum]>gi|270009704|gb|EFA06152.1| hypothetical protein TcasGA2_TC008997 [Tribolium castaneum] 665813619 XM_008557152.1 150 1.18202e-69 PREDICTED: Microplitis demolitor tetratricopeptide repeat protein 30A (LOC103576769), mRNA -- -- -- -- A4IHR1 2322 9.4e-260 Tetratricopeptide repeat protein 30A OS=Xenopus tropicalis GN=ttc30a PE=2 SV=1 PF00031//PF13181//PF13414//PF00333//PF08912//PF13176//PF00112//PF00515 Cystatin domain//Tetratricopeptide repeat//TPR repeat//Ribosomal protein S5, N-terminal domain//Rho Binding//Tetratricopeptide repeat//Papain family cysteine protease//Tetratricopeptide repeat GO:0006412//GO:0042254//GO:0006508 translation//ribosome biogenesis//proteolysis GO:0004869//GO:0005515//GO:0003723//GO:0017048//GO:0008234//GO:0003735 cysteine-type endopeptidase inhibitor activity//protein binding//RNA binding//Rho GTPase binding//cysteine-type peptidase activity//structural constituent of ribosome GO:0005840 ribosome KOG1542 Cysteine proteinase Cathepsin F Cluster-8309.41552 BF_2 1062.75 6.26 7391 642922200 XP_008193059.1 2331 2.4e-259 PREDICTED: patronin isoform X6 [Tribolium castaneum] 645007691 XM_008218148.1 74 2.46087e-27 PREDICTED: Nasonia vitripennis patronin (LOC100118026), mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 1202 8.2e-130 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF00487//PF17095//PF00159//PF00307 Fatty acid desaturase//Spectrin-binding region of Ca2+-Calmodulin//Pancreatic hormone peptide//Calponin homology (CH) domain GO:0006629//GO:0007165//GO:0031175 lipid metabolic process//signal transduction//neuron projection development GO:0005179//GO:0005515//GO:0005516//GO:0030507 hormone activity//protein binding//calmodulin binding//spectrin binding GO:0005576//GO:0008091 extracellular region//spectrin KOG3654 Uncharacterized CH domain protein Cluster-8309.41553 BF_2 1749.53 28.99 2812 198475573 XP_002132955.1 673 1.7e-67 GA26108 [Drosophila pseudoobscura pseudoobscura]>gi|198138883|gb|EDY70357.1| GA26108 [Drosophila pseudoobscura pseudoobscura] 194893319 XM_001977817.1 90 1.18514e-36 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- Q8R4Y4 198 8.3e-14 Stabilin-1 OS=Mus musculus GN=Stab1 PE=1 SV=1 PF00558//PF07527//PF04882//PF00008 Vpu protein//Hairy Orange//Peroxin-3//EGF-like domain GO:0019076//GO:0007031//GO:0032801//GO:0006812//GO:0006355 viral release from host cell//peroxisome organization//receptor catabolic process//cation transport//regulation of transcription, DNA-templated GO:0005515//GO:0005261//GO:0003677 protein binding//cation channel activity//DNA binding GO:0005779//GO:0033644 integral component of peroxisomal membrane//host cell membrane KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.41554 BF_2 222.67 11.39 1105 91090188 XP_966752.1 1317 1.4e-142 PREDICTED: tetraspanin-33 [Tribolium castaneum]>gi|270013472|gb|EFA09920.1| hypothetical protein TcasGA2_TC012071 [Tribolium castaneum] -- -- -- -- -- K17346 TSPAN33 tetraspanin-33 http://www.genome.jp/dbget-bin/www_bget?ko:K17346 Q8R3S2 559 4.5e-56 Tetraspanin-33 OS=Mus musculus GN=Tspan33 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.41556 BF_2 1357.54 6.04 9688 642930211 XP_008196303.1 2794 0.0e+00 PREDICTED: protein aubergine [Tribolium castaneum]>gi|642930213|ref|XP_008196304.1| PREDICTED: protein aubergine [Tribolium castaneum]>gi|270010977|gb|EFA07425.1| piwi [Tribolium castaneum] 820846169 XM_003692874.2 149 6.55944e-69 PREDICTED: Apis florea general transcription factor IIE subunit 2 (LOC100864753), mRNA K02156 AUB, PIWI aubergine http://www.genome.jp/dbget-bin/www_bget?ko:K02156 O76922 1693 1.3e-186 Protein aubergine OS=Drosophila melanogaster GN=aub PE=1 SV=1 PF09494//PF07859//PF01764//PF15384//PF02186//PF02170//PF02230//PF02171//PF04636 Slx4 endonuclease//alpha/beta hydrolase fold//Lipase (class 3)//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//TFIIE beta subunit core domain//PAZ domain//Phospholipase/Carboxylesterase//Piwi domain//PA26 p53-induced protein (sestrin) GO:0008152//GO:0006281//GO:0006303//GO:0006629//GO:0006260//GO:0006308//GO:0006367//GO:1901031 metabolic process//DNA repair//double-strand break repair via nonhomologous end joining//lipid metabolic process//DNA replication//DNA catabolic process//transcription initiation from RNA polymerase II promoter//regulation of response to reactive oxygen species GO:0016787//GO:0017108//GO:0005515//GO:0003676 hydrolase activity//5'-flap endonuclease activity//protein binding//nucleic acid binding GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex KOG1042 Germ-line stem cell division protein Hiwi/Piwi; negative developmental regulator Cluster-8309.41558 BF_2 491.00 2.33 9118 270007552 EFA04000.1 501 4.8e-47 hypothetical protein TcasGA2_TC014149 [Tribolium castaneum] 462336464 APGK01037882.1 162 3.66242e-76 Dendroctonus ponderosae Seq01037892, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF06662 D-glucuronyl C5-epimerase C-terminus GO:0006024 glycosaminoglycan biosynthetic process GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives GO:0016021 integral component of membrane -- -- Cluster-8309.41560 BF_2 107.90 0.90 5297 189240620 XP_001807833.1 1647 3.6e-180 PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|642933748|ref|XP_008191504.1| PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|270013625|gb|EFA10073.1| hypothetical protein TcasGA2_TC012247 [Tribolium castaneum] 242003577 XM_002422736.1 104 3.70563e-44 Pediculus humanus corporis hypothetical protein, mRNA -- -- -- -- Q02525 213 2.8e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00096 Zinc finger, C2H2 type -- -- GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.41561 BF_2 296.10 1.98 6553 189240620 XP_001807833.1 1647 4.5e-180 PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|642933748|ref|XP_008191504.1| PREDICTED: uncharacterized protein LOC100142352 [Tribolium castaneum]>gi|270013625|gb|EFA10073.1| hypothetical protein TcasGA2_TC012247 [Tribolium castaneum] 242003577 XM_002422736.1 104 4.58815e-44 Pediculus humanus corporis hypothetical protein, mRNA -- -- -- -- Q02525 213 3.5e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF00096//PF00628 Zinc finger, C2H2 type//PHD-finger -- -- GO:0046872//GO:0005515//GO:0008270//GO:0003676 metal ion binding//protein binding//zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.41562 BF_2 110.42 1.70 2998 780653487 XP_011691003.1 1373 1.2e-148 PREDICTED: pescadillo homolog [Wasmannia auropunctata] -- -- -- -- -- K14843 PES1, NOP7 pescadillo http://www.genome.jp/dbget-bin/www_bget?ko:K14843 B4KID9 1186 2.4e-128 Pescadillo homolog OS=Drosophila mojavensis GN=GI18209 PE=3 SV=1 PF06732 Pescadillo N-terminus GO:0042254 ribosome biogenesis -- -- GO:0005730 nucleolus KOG2481 Protein required for normal rRNA processing Cluster-8309.41563 BF_2 51.53 0.40 5616 91091668 XP_971563.1 1168 1.3e-124 PREDICTED: docking protein 2 [Tribolium castaneum]>gi|270001055|gb|EEZ97502.1| hypothetical protein TcasGA2_TC011346 [Tribolium castaneum] -- -- -- -- -- K17808 ZIM17, DNLZ, Tim15 mitochondrial protein import protein ZIM17 http://www.genome.jp/dbget-bin/www_bget?ko:K17808 A1L1P7 281 3.9e-23 DNL-type zinc finger protein OS=Danio rerio GN=dnlz PE=2 SV=1 PF05180//PF02174 DNL zinc finger//PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0008270//GO:0005158 zinc ion binding//insulin receptor binding GO:0005899 insulin receptor complex KOG3277 Uncharacterized conserved protein Cluster-8309.41564 BF_2 709.28 4.09 7538 642911773 XP_008200735.1 2249 8.0e-250 PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911775|ref|XP_008200736.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911777|ref|XP_008200737.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|642911779|ref|XP_008200738.1| PREDICTED: trehalase-like isoform X1 [Tribolium castaneum]>gi|270014735|gb|EFA11183.1| hypothetical protein TcasGA2_TC004791 [Tribolium castaneum] 397560823 JX204291.1 38 2.5821e-07 Sogatella furcifera membrane-bound trehalase mRNA, complete cds K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 A8J4S9 1814 9.1e-201 Trehalase OS=Apis mellifera PE=1 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.41566 BF_2 79.54 2.07 1892 642934971 XP_008196003.1 1022 3.8e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 9.83236e-66 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41567 BF_2 57.61 2.39 1294 642934971 XP_008196003.1 1255 2.5e-135 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] -- -- -- -- -- K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 Q80Z30 653 6.6e-67 Protein phosphatase 1E OS=Rattus norvegicus GN=Ppm1e PE=1 SV=1 PF07228//PF01090//PF01006//PF00481 Stage II sporulation protein E (SpoIIE)//Ribosomal protein S19e//Hepatitis C virus non-structural protein NS4a//Protein phosphatase 2C GO:0042254//GO:0006412//GO:0016032 ribosome biogenesis//translation//viral process GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840//GO:0019012 ribosome//virion KOG0698 Serine/threonine protein phosphatase Cluster-8309.41568 BF_2 262.80 4.11 2963 642934971 XP_008196003.1 1255 5.7e-135 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] -- -- -- -- -- K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 Q80Z30 653 1.5e-66 Protein phosphatase 1E OS=Rattus norvegicus GN=Ppm1e PE=1 SV=1 PF00481//PF01006//PF01090//PF07228 Protein phosphatase 2C//Hepatitis C virus non-structural protein NS4a//Ribosomal protein S19e//Stage II sporulation protein E (SpoIIE) GO:0016032//GO:0042254//GO:0006412 viral process//ribosome biogenesis//translation GO:0003824//GO:0003735 catalytic activity//structural constituent of ribosome GO:0019012//GO:0005840 virion//ribosome KOG0698 Serine/threonine protein phosphatase Cluster-8309.41569 BF_2 12.30 0.31 1924 642934971 XP_008196003.1 1672 1.7e-183 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] -- -- -- -- -- K17501 PPM1E, POPX1 protein phosphatase 1E http://www.genome.jp/dbget-bin/www_bget?ko:K17501 Q8WY54 673 4.7e-69 Protein phosphatase 1E OS=Homo sapiens GN=PPM1E PE=1 SV=2 PF00481//PF01090//PF07228 Protein phosphatase 2C//Ribosomal protein S19e//Stage II sporulation protein E (SpoIIE) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0003824 structural constituent of ribosome//catalytic activity GO:0005840 ribosome KOG0698 Serine/threonine protein phosphatase Cluster-8309.41570 BF_2 44.67 0.34 5828 642921963 XP_008192963.1 2164 4.4e-240 PREDICTED: uncharacterized protein LOC658725 [Tribolium castaneum]>gi|270007382|gb|EFA03830.1| hypothetical protein TcasGA2_TC013946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005543 phospholipid binding -- -- -- -- Cluster-8309.41573 BF_2 355.90 4.61 3518 91079945 XP_968596.1 3239 0.0e+00 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003256|gb|EEZ99703.1| hypothetical protein TcasGA2_TC002464 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 2090 4.2e-233 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF07748//PF01074//PF09261 Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain//Alpha mannosidase, middle domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923//GO:0004559//GO:0004553//GO:0043169//GO:0008270 mannosidase activity//alpha-mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//zinc ion binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.41574 BF_2 3991.56 54.98 3324 91079945 XP_968596.1 3239 0.0e+00 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003256|gb|EEZ99703.1| hypothetical protein TcasGA2_TC002464 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 2090 4.0e-233 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF09261//PF01074//PF07748 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923//GO:0004559//GO:0004553//GO:0043169//GO:0008270 mannosidase activity//alpha-mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//zinc ion binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.41575 BF_2 231.64 3.07 3446 91079945 XP_968596.1 3239 0.0e+00 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003256|gb|EEZ99703.1| hypothetical protein TcasGA2_TC002464 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 2090 4.1e-233 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF07748//PF01074//PF09261 Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain//Alpha mannosidase, middle domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0008270//GO:0043169//GO:0004553//GO:0004559//GO:0015923 zinc ion binding//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.41577 BF_2 2.10 0.40 505 91076410 XP_969526.1 402 8.0e-37 PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002563|gb|EEZ99010.1| hypothetical protein TcasGA2_TC004878 [Tribolium castaneum] 731510745 XM_010600440.1 48 4.49131e-14 PREDICTED: Loxodonta africana aldose reductase-related protein 2-like (LOC100673621), mRNA K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 317 2.4e-28 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.41578 BF_2 7052.61 199.63 1765 254911123 NP_001157182.1 945 3.0e-99 cactus isoform 2 [Tribolium castaneum]>gi|270016252|gb|EFA12698.1| cactus [Tribolium castaneum] -- -- -- -- -- K09259 K09259 ankyrin only family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09259 Q03017 521 1.8e-51 NF-kappa-B inhibitor cactus OS=Drosophila melanogaster GN=cact PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41581 BF_2 552.00 7.36 3423 91091382 XP_973347.1 987 7.9e-104 PREDICTED: fibroblast growth factor receptor substrate 3 [Tribolium castaneum]>gi|270013059|gb|EFA09507.1| hypothetical protein TcasGA2_TC011609 [Tribolium castaneum] -- -- -- -- -- K12461 FRS2 fibroblast growth factor receptor substrate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12461 Q8C180 275 1.2e-22 Fibroblast growth factor receptor substrate 2 OS=Mus musculus GN=Frs2 PE=1 SV=3 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.41582 BF_2 1188.85 15.53 3490 189234059 XP_969658.2 2716 2.6e-304 PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|642911998|ref|XP_008199054.1| PREDICTED: transmembrane protein 63A [Tribolium castaneum]>gi|270014437|gb|EFA10885.1| hypothetical protein TcasGA2_TC001709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TWI9 1057 2.5e-113 CSC1-like protein 2 OS=Mus musculus GN=Tmem63b PE=1 SV=1 PF02714 Calcium-dependent channel, 7TM region, putative phosphate -- -- -- -- GO:0016020 membrane KOG1134 Uncharacterized conserved protein Cluster-8309.41586 BF_2 180.00 2.86 2922 642931096 XP_974337.3 498 3.4e-47 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWU1 342 1.7e-30 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.41587 BF_2 2266.91 14.76 6714 478261414 ENN80791.1 4569 0.0e+00 hypothetical protein YQE_02800, partial [Dendroctonus ponderosae]>gi|546680987|gb|ERL91161.1| hypothetical protein D910_08501 [Dendroctonus ponderosae] 815771795 XM_012380628.1 476 0 PREDICTED: Linepithema humile ATP-dependent helicase brm (LOC105680160), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 Q3TKT4 3297 0.0e+00 Transcription activator BRG1 OS=Mus musculus GN=Smarca4 PE=1 SV=1 PF00176//PF07533//PF14619//PF04851//PF00270//PF00439//PF08880 SNF2 family N-terminal domain//BRK domain//Snf2-ATP coupling, chromatin remodelling complex//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Bromodomain//QLQ GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0042393//GO:0016817//GO:0005524//GO:0016787//GO:0003677//GO:0005515 nucleic acid binding//histone binding//hydrolase activity, acting on acid anhydrides//ATP binding//hydrolase activity//DNA binding//protein binding GO:0005634 nucleus KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.41588 BF_2 2596.63 15.79 7166 478263704 ENN82007.1 2238 1.4e-248 hypothetical protein YQE_01582, partial [Dendroctonus ponderosae]>gi|546671060|gb|ERL83542.1| hypothetical protein D910_00613 [Dendroctonus ponderosae]>gi|546672516|gb|ERL84345.1| hypothetical protein D910_01767 [Dendroctonus ponderosae] -- -- -- -- -- K03544 clpX, CLPX ATP-dependent Clp protease ATP-binding subunit ClpX http://www.genome.jp/dbget-bin/www_bget?ko:K03544 Q5U2U0 1533 3.3e-168 ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial OS=Rattus norvegicus GN=Clpx PE=2 SV=1 PF06068//PF00158//PF01057//PF05496//PF07728//PF01695//PF14532//PF07724//PF00004//PF00437//PF02367//PF02562//PF00005//PF10662//PF00270 TIP49 C-terminus//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ABC transporter//Ethanolamine utilisation - propanediol utilisation//DEAD/DEAH box helicase GO:0019079//GO:0006281//GO:0006810//GO:0006355//GO:0006576//GO:0006310//GO:0002949 viral genome replication//DNA repair//transport//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0008134//GO:0016887//GO:0003678//GO:0003676//GO:0009378 ATP binding//transcription factor binding//ATPase activity//DNA helicase activity//nucleic acid binding//four-way junction helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0745 Putative ATP-dependent Clp-type protease (AAA+ ATPase superfamily) Cluster-8309.41589 BF_2 1353.96 31.11 2108 189235662 XP_001811794.1 1463 3.1e-159 PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum]>gi|642917553|ref|XP_008191254.1| PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41590 BF_2 364.94 7.78 2250 189235662 XP_001811794.1 1463 3.3e-159 PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum]>gi|642917553|ref|XP_008191254.1| PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41594 BF_2 127.95 2.71 2265 546673600 ERL85164.1 1732 2.1e-190 hypothetical protein D910_02586 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q14728 936 1.8e-99 Major facilitator superfamily domain-containing protein 10 OS=Homo sapiens GN=MFSD10 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2615 Permease of the major facilitator superfamily Cluster-8309.41595 BF_2 51.05 0.77 3078 546673600 ERL85164.1 1729 6.5e-190 hypothetical protein D910_02586 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q14728 936 2.4e-99 Major facilitator superfamily domain-containing protein 10 OS=Homo sapiens GN=MFSD10 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2615 Permease of the major facilitator superfamily Cluster-8309.41596 BF_2 214.81 1.16 8019 270007809 EFA04257.1 634 1.6e-62 hypothetical protein TcasGA2_TC014547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IIG7 207 2.1e-14 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF00612//PF04644 IQ calmodulin-binding motif//Motilin/ghrelin GO:0007165 signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.41598 BF_2 2792.19 15.18 7983 642923994 XP_967135.2 372 3.8e-32 PREDICTED: microtubule-associated protein futsch-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IIG7 207 2.1e-14 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF04644//PF00612 Motilin/ghrelin//IQ calmodulin-binding motif GO:0007165 signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.41600 BF_2 52.00 2.11 1319 270015247 EFA11695.1 808 1.7e-83 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.41603 BF_2 230.60 1.04 9581 91087223 XP_975486.1 6932 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X2 [Tribolium castaneum] 642929668 XM_970393.2 238 2.17369e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 2114 1.9e-235 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF01155//PF00130//PF03110//PF04135//PF03367//PF02145 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//SBP domain//Nucleolar RNA-binding protein, Nop10p family//ZPR1 zinc-finger domain//Rap/ran-GAP GO:0006464//GO:0051056//GO:0042254//GO:0035556//GO:0001522 cellular protein modification process//regulation of small GTPase mediated signal transduction//ribosome biogenesis//intracellular signal transduction//pseudouridine synthesis GO:0003677//GO:0005096//GO:0030515//GO:0016151//GO:0008270 DNA binding//GTPase activator activity//snoRNA binding//nickel cation binding//zinc ion binding GO:0072588//GO:0005634 box H/ACA RNP complex//nucleus KOG2703 C4-type Zn-finger protein Cluster-8309.41606 BF_2 944.07 4.46 9136 91085247 XP_973234.1 3413 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 316 9.0469e-162 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2247 6.8e-251 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF00015//PF02985//PF08064//PF11698//PF05997//PF14372//PF06009//PF07690//PF00083 Methyl-accepting chemotaxis protein (MCP) signalling domain//HEAT repeat//UME (NUC010) domain//V-ATPase subunit H//Nucleolar protein,Nop52//Domain of unknown function (DUF4413)//Laminin Domain II//Major Facilitator Superfamily//Sugar (and other) transporter GO:0006364//GO:0055085//GO:0007165//GO:0009069//GO:0007155//GO:0016310//GO:0015991 rRNA processing//transmembrane transport//signal transduction//serine family amino acid metabolic process//cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport GO:0004674//GO:0004871//GO:0003677//GO:0022857//GO:0016820//GO:0005515 protein serine/threonine kinase activity//signal transducer activity//DNA binding//transmembrane transporter activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0030688//GO:0016021//GO:0016020//GO:0000221 preribosome, small subunit precursor//integral component of membrane//membrane//vacuolar proton-transporting V-type ATPase, V1 domain KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.41607 BF_2 135.00 2.50 2544 91090674 XP_974487.1 2441 1.5e-272 PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|642935631|ref|XP_008198090.1| PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|642935634|ref|XP_008198091.1| PREDICTED: D-glucuronyl C5-epimerase [Tribolium castaneum]>gi|270013933|gb|EFA10381.1| hypothetical protein TcasGA2_TC012612 [Tribolium castaneum] 665801709 XM_008550658.1 129 2.23876e-58 PREDICTED: Microplitis demolitor D-glucuronyl C5-epimerase (LOC103572179), mRNA K01793 GLCE heparosan-N-sulfate-glucuronate 5-epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K01793 Q9EPS3 1331 3.1e-145 D-glucuronyl C5-epimerase OS=Mus musculus GN=Glce PE=1 SV=2 PF11734//PF09115//PF06662 TilS substrate C-terminal domain//DNA polymerase III, delta subunit, C terminal//D-glucuronyl C5-epimerase C-terminus GO:0006024//GO:0008033//GO:0006260 glycosaminoglycan biosynthetic process//tRNA processing//DNA replication GO:0003887//GO:0016879//GO:0016857//GO:0003677//GO:0005524//GO:0000166 DNA-directed DNA polymerase activity//ligase activity, forming carbon-nitrogen bonds//racemase and epimerase activity, acting on carbohydrates and derivatives//DNA binding//ATP binding//nucleotide binding GO:0042575//GO:0009360//GO:0016021//GO:0005737 DNA polymerase complex//DNA polymerase III complex//integral component of membrane//cytoplasm KOG3760 Heparan sulfate-glucuronic acid C5-epimerase Cluster-8309.41609 BF_2 128.59 1.19 4818 642931172 XP_008196469.1 2267 4.2e-252 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41610 BF_2 86.91 3.12 1451 189239889 XP_969643.2 569 9.9e-56 PREDICTED: uncharacterized protein LOC658141 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41612 BF_2 15.90 0.36 2112 642915063 XP_008190394.1 900 6.0e-94 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 380 4.9e-35 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF02770//PF02771//PF00441//PF09057 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain//Second Mitochondria-derived Activator of Caspases GO:0008152//GO:0006915//GO:0055114//GO:0006919//GO:0006118 metabolic process//apoptotic process//oxidation-reduction process//activation of cysteine-type endopeptidase activity involved in apoptotic process//obsolete electron transport GO:0003995//GO:0016627//GO:0050660 acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding GO:0005739 mitochondrion KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.41613 BF_2 173.83 3.08 2646 642923366 XP_973695.2 486 7.6e-46 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41615 BF_2 1.00 1.19 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41617 BF_2 1537.87 14.51 4720 270004796 EFA01244.1 1297 1.2e-139 sprouty-related protein with EVH-1 domain [Tribolium castaneum] 237823395 AB443867.1 36 2.08642e-06 Culex quinquefasciatus CqGSTd1 gene for glutathione transferase, complete cds, alternative splicing K04703 SPRED sprouty-related, EVH1 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04703 Q66JG9 467 8.9e-45 Sprouty-related, EVH1 domain-containing protein 1 OS=Xenopus tropicalis GN=spred1 PE=1 SV=1 PF02798//PF13417//PF05210//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Sprouty protein (Spry)//Glutathione S-transferase, N-terminal domain GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.41618 BF_2 123.50 3.58 1732 557771007 XP_005185166.1 383 4.4e-34 PREDICTED: glutathione S-transferase 1-like [Musca domestica] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 329 3.3e-29 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41619 BF_2 197.87 3.38 2738 546684140 ERL93845.1 973 2.7e-102 hypothetical protein D910_11131 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 307 1.8e-26 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF00560//PF13409//PF13855//PF02798//PF13417//PF00462 Leucine Rich Repeat//Glutathione S-transferase, N-terminal domain//Leucine rich repeat//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0005515//GO:0015035//GO:0009055 protein binding//protein disulfide oxidoreductase activity//electron carrier activity -- -- -- -- Cluster-8309.41620 BF_2 113.27 0.81 6126 642918795 XP_008191588.1 293 4.2e-23 PREDICTED: uncharacterized protein LOC103312529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41621 BF_2 1545.91 15.39 4490 91086569 XP_973078.1 2043 3.7e-226 PREDICTED: E3 ubiquitin-protein ligase AMFR-like [Tribolium castaneum] -- -- -- -- -- K10636 AMFR, GP78 autocrine motility factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10636 Q9UKV5 1150 5.4e-124 E3 ubiquitin-protein ligase AMFR OS=Homo sapiens GN=AMFR PE=1 SV=2 PF02537//PF14634//PF12906//PF17123//PF12678//PF00097//PF17122//PF13639//PF12861//PF02845 CrcB-like protein, Camphor Resistance (CrcB)//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//CUE domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680//GO:0016021 anaphase-promoting complex//integral component of membrane KOG0802 E3 ubiquitin ligase Cluster-8309.41624 BF_2 206.77 3.47 2778 557876145 AHA39267.1 269 1.2e-20 odorant-binding protein 2 [Monochamus alternatus]>gi|758343051|gb|AJO67867.1| odorant binding protein 2 [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395//PF02391//PF02522//PF15234 PBP/GOBP family//MoaE protein//Aminoglycoside 3-N-acetyltransferase//Linker for activation of T-cells GO:0042967//GO:0006777//GO:0046677//GO:0007165 acyl-carrier-protein biosynthetic process//Mo-molybdopterin cofactor biosynthetic process//response to antibiotic//signal transduction GO:0005549//GO:0046353 odorant binding//aminoglycoside 3-N-acetyltransferase activity GO:0016020 membrane -- -- Cluster-8309.41625 BF_2 30.40 0.42 3294 189242134 XP_968235.2 1493 1.6e-162 PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 1.0e-111 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF13174//PF01770//PF13181//PF13176//PF13414//PF04812//PF00515//PF05793//PF05118//PF02737 Tetratricopeptide repeat//Reduced folate carrier//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//Tetratricopeptide repeat//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Aspartyl/Asparaginyl beta-hydroxylase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0032968//GO:0018874//GO:0006633//GO:0006631//GO:0018193//GO:0006552//GO:0006367//GO:0006550//GO:0006574//GO:0006810//GO:0006568//GO:0045893//GO:0006554//GO:0055114 positive regulation of transcription elongation from RNA polymerase II promoter//benzoate metabolic process//fatty acid biosynthetic process//fatty acid metabolic process//peptidyl-amino acid modification//leucine catabolic process//transcription initiation from RNA polymerase II promoter//isoleucine catabolic process//valine catabolic process//transport//tryptophan metabolic process//positive regulation of transcription, DNA-templated//lysine catabolic process//oxidation-reduction process GO:0003677//GO:0016491//GO:0005515//GO:0003857 DNA binding//oxidoreductase activity//protein binding//3-hydroxyacyl-CoA dehydrogenase activity GO:0005634//GO:0016020 nucleus//membrane KOG3696 Aspartyl beta-hydroxylase Cluster-8309.41626 BF_2 3083.65 28.87 4755 780140340 XP_011680553.1 564 1.2e-54 PREDICTED: titin [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q23551 541 2.4e-53 Twitchin OS=Caenorhabditis elegans GN=unc-22 PE=1 SV=3 PF00041//PF13895//PF00319//PF16656 Fibronectin type III domain//Immunoglobulin domain//SRF-type transcription factor (DNA-binding and dimerisation domain)//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0046983//GO:0003677//GO:0003993 metal ion binding//protein binding//protein dimerization activity//DNA binding//acid phosphatase activity -- -- KOG0613 Projectin/twitchin and related proteins Cluster-8309.41628 BF_2 29.11 0.70 2015 478253752 ENN74046.1 716 1.2e-72 hypothetical protein YQE_09337, partial [Dendroctonus ponderosae] 268574973 XM_002642420.1 86 1.41495e-34 Caenorhabditis briggsae C. briggsae CBR-UNC-32 protein (Cbr-unc-32) mRNA, complete cds K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9I8D0 601 1.1e-60 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Gallus gallus GN=ATP6V0A1 PE=1 SV=1 PF01517//PF16326//PF04111//PF01496//PF00769 Hepatitis delta virus delta antigen//ABC transporter C-terminal domain//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Ezrin/radixin/moesin family GO:0015992//GO:0015991//GO:0006914 proton transport//ATP hydrolysis coupled proton transport//autophagy GO:0015078//GO:0003677//GO:0003723//GO:0008092 hydrogen ion transmembrane transporter activity//DNA binding//RNA binding//cytoskeletal protein binding GO:0005737//GO:0033179//GO:0042025//GO:0019898 cytoplasm//proton-transporting V-type ATPase, V0 domain//host cell nucleus//extrinsic component of membrane KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.41632 BF_2 667.75 7.36 4085 91077414 XP_975386.1 1918 1.0e-211 PREDICTED: heat shock 70 kDa protein cognate 5 [Tribolium castaneum]>gi|270001633|gb|EEZ98080.1| hypothetical protein TcasGA2_TC000487 [Tribolium castaneum] 589060793 KF986612.1 380 0 Epicauta chinensis heat shock 70 kDa protein cognate 5-like protein mRNA, complete cds K04043 dnaK molecular chaperone DnaK http://www.genome.jp/dbget-bin/www_bget?ko:K04043 P29845 1693 5.3e-187 Heat shock 70 kDa protein cognate 5 OS=Drosophila melanogaster GN=Hsc70-5 PE=1 SV=2 PF12634//PF13414//PF02782//PF06723//PF00516//PF15281 Inheritance of peroxisomes protein 1//TPR repeat//FGGY family of carbohydrate kinases, C-terminal domain//MreB/Mbl protein//Envelope glycoprotein GP120//Consortin C-terminus GO:0042998//GO:0006457//GO:0005975//GO:0000902//GO:0045033 positive regulation of Golgi to plasma membrane protein transport//protein folding//carbohydrate metabolic process//cell morphogenesis//peroxisome inheritance GO:0005515//GO:0071253//GO:0005524//GO:0016773//GO:0051082 protein binding//connexin binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//unfolded protein binding GO:0005802//GO:0019031//GO:0005780 trans-Golgi network//viral envelope//extrinsic component of intraperoxisomal membrane KOG0102 Molecular chaperones mortalin/PBP74/GRP75, HSP70 superfamily Cluster-8309.41633 BF_2 587.50 6.83 3883 478256593 ENN76775.1 3637 0.0e+00 hypothetical protein YQE_06616, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8CFG5 1356 6.0e-148 Voltage-dependent calcium channel subunit alpha-2/delta-3 OS=Rattus norvegicus GN=Cacna2d3 PE=1 SV=1 PF08030 Ferric reductase NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.41634 BF_2 811.30 13.94 2722 642921258 XP_008192788.1 1737 6.8e-191 PREDICTED: serine/threonine-protein phosphatase PP1-beta catalytic subunit isoform X1 [Tribolium castaneum] 597735941 XM_007230177.1 329 1.58522e-169 PREDICTED: Astyanax mexicanus serine/threonine-protein phosphatase PP1-beta catalytic subunit-like (LOC103033313), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q5I085 1654 1.2e-182 Serine/threonine-protein phosphatase PP1-beta catalytic subunit OS=Xenopus tropicalis GN=ppp1cb PE=2 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.41636 BF_2 624.14 2.13 12527 642914032 XP_008201515.1 5554 0.0e+00 PREDICTED: syntaxin-binding protein 5 isoform X2 [Tribolium castaneum] 751777385 XM_011199394.1 86 8.91998e-34 PREDICTED: Bactrocera dorsalis probable ATP-dependent RNA helicase DDX10 (LOC105222182), mRNA K08518 STXBP5 syntaxin-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08518 Q9WU70 2011 2.2e-223 Syntaxin-binding protein 5 OS=Rattus norvegicus GN=Stxbp5 PE=1 SV=1 PF00802//PF11616//PF00957//PF00270//PF01218//PF11427//PF04992//PF00400 Pneumovirus attachment glycoprotein G//WD repeat binding protein EZH2//Synaptobrevin//DEAD/DEAH box helicase//Coproporphyrinogen III oxidase//Tc3 transposase//RNA polymerase Rpb1, domain 6//WD domain, G-beta repeat GO:0006206//GO:0006479//GO:0015994//GO:0006144//GO:0006351//GO:0055114//GO:0006554//GO:0006779//GO:0016192 pyrimidine nucleobase metabolic process//protein methylation//chlorophyll metabolic process//purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//lysine catabolic process//porphyrin-containing compound biosynthetic process//vesicle-mediated transport GO:0003676//GO:0005515//GO:0004109//GO:0003677//GO:0018024//GO:0005524//GO:0003899 nucleic acid binding//protein binding//coproporphyrinogen oxidase activity//DNA binding//histone-lysine N-methyltransferase activity//ATP binding//DNA-directed RNA polymerase activity GO:0005730//GO:0055036//GO:0016021 nucleolus//virion membrane//integral component of membrane KOG0343 RNA Helicase Cluster-8309.41637 BF_2 1385.06 54.16 1357 270010528 EFA06976.1 217 6.0e-15 hypothetical protein TcasGA2_TC009936 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y7Y3 141 1.6e-07 Uncharacterized RNA-binding protein C365.04c OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPBC365.04c PE=3 SV=1 PF00076//PF04449//PF03153 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//CS1 type fimbrial major subunit//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003676 nucleic acid binding GO:0009289//GO:0005672 pilus//transcription factor TFIIA complex -- -- Cluster-8309.41638 BF_2 1599.68 87.04 1056 642928066 XP_008200141.1 174 4.6e-10 PREDICTED: serine protease inhibitor I/II-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- -- -- Cluster-8309.41640 BF_2 510.00 8.64 2756 270005740 EFA02188.1 4069 0.0e+00 hypothetical protein TcasGA2_TC007844 [Tribolium castaneum] 768430832 XM_011558359.1 42 5.59722e-10 PREDICTED: Plutella xylostella teneurin-a (LOC105387609), partial mRNA -- -- -- -- Q9VYN8 3168 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41642 BF_2 213.35 0.97 9494 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 6.16046e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF00071//PF01580//PF00493//PF02272//PF01411//PF01018//PF03193//PF00400//PF00005//PF01399//PF00025//PF02421//PF01343//PF07973//PF01926 Ras family//FtsK/SpoIIIE family//MCM2/3/5 family//DHHA1 domain//tRNA synthetases class II (A)//GTP1/OBG//Protein of unknown function, DUF258//WD domain, G-beta repeat//ABC transporter//PCI domain//ADP-ribosylation factor family//Ferrous iron transport protein B//Peptidase family S49//Threonyl and Alanyl tRNA synthetase second additional domain//50S ribosome-binding GTPase GO:0043039//GO:0007264//GO:0006413//GO:0006508//GO:0006522//GO:0006446//GO:0006531//GO:0006419//GO:0015684//GO:0006260 tRNA aminoacylation//small GTPase mediated signal transduction//translational initiation//proteolysis//alanine metabolic process//regulation of translational initiation//aspartate metabolic process//alanyl-tRNA aminoacylation//ferrous iron transport//DNA replication GO:0003676//GO:0005525//GO:0005515//GO:0004813//GO:0003677//GO:0015093//GO:0016876//GO:0008233//GO:0016887//GO:0000166//GO:0003924//GO:0003743//GO:0005524 nucleic acid binding//GTP binding//protein binding//alanine-tRNA ligase activity//DNA binding//ferrous iron transmembrane transporter activity//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//ATPase activity//nucleotide binding//GTPase activity//translation initiation factor activity//ATP binding GO:0005737//GO:0005840//GO:0016021 cytoplasm//ribosome//integral component of membrane KOG0188 Alanyl-tRNA synthetase Cluster-8309.41643 BF_2 192.00 26.96 585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41644 BF_2 26.65 4.89 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41646 BF_2 88.46 9.42 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41651 BF_2 19.00 5.66 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41652 BF_2 54.01 1.02 2507 332375600 AEE62941.1 1142 6.2e-122 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7T3C7 340 2.5e-30 Reticulon-4-interacting protein 1 homolog, mitochondrial OS=Danio rerio GN=rtn4ip1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.41654 BF_2 347.53 2.75 5573 642927835 XP_972081.2 781 9.9e-80 PREDICTED: LOW QUALITY PROTEIN: probable glucosamine 6-phosphate N-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00621 GNPNAT1, GNA1 glucosamine-phosphate N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00621 Q9VAI0 611 2.1e-61 Probable glucosamine 6-phosphate N-acetyltransferase OS=Drosophila melanogaster GN=CG1969 PE=2 SV=1 PF13508//PF00583//PF13673 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3396 Glucosamine-phosphate N-acetyltransferase Cluster-8309.41657 BF_2 244.21 1.82 5909 546683250 ERL93082.1 1097 2.4e-116 hypothetical protein D910_10384 [Dendroctonus ponderosae] 597773854 XM_007250594.1 78 1.17483e-29 PREDICTED: Astyanax mexicanus activin receptor type-2A-like (LOC103032572), transcript variant X4, mRNA K13596 ACVR2B activin receptor type-2B http://www.genome.jp/dbget-bin/www_bget?ko:K13596 P27039 654 2.3e-66 Activin receptor type-2A OS=Xenopus laevis GN=acvr2a PE=2 SV=1 PF07714//PF16782//PF01064//PF00069 Protein tyrosine kinase//Nucleotide exchange factor SIL1//Activin types I and II receptor domain//Protein kinase domain GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0000774//GO:0004675//GO:0004672//GO:0005524 adenyl-nucleotide exchange factor activity//transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020//GO:0005783 membrane//endoplasmic reticulum -- -- Cluster-8309.4166 BF_2 3.00 0.41 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41661 BF_2 9.83 0.44 1223 478251161 ENN71637.1 613 6.6e-61 hypothetical protein YQE_11735, partial [Dendroctonus ponderosae]>gi|546685822|gb|ERL95265.1| hypothetical protein D910_12531 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P15278 230 7.0e-18 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41664 BF_2 312.43 2.21 6208 642914669 XP_008190307.1 3009 0.0e+00 PREDICTED: uncharacterized protein LOC662983 isoform X2 [Tribolium castaneum] 642914670 XM_008192087.1 68 4.47207e-24 PREDICTED: Tribolium castaneum uncharacterized LOC662983 (LOC662983), transcript variant X3, mRNA -- -- -- -- Q6P2X9 431 1.7e-40 Monocarboxylate transporter 12 OS=Xenopus tropicalis GN=slc16a12 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41665 BF_2 856.71 17.21 2369 91090079 XP_969933.1 1422 2.0e-154 PREDICTED: twinfilin [Tribolium castaneum]>gi|270013504|gb|EFA09952.1| hypothetical protein TcasGA2_TC012105 [Tribolium castaneum] -- -- -- -- -- K08870 TWF twinfilin http://www.genome.jp/dbget-bin/www_bget?ko:K08870 Q17A58 1087 5.7e-117 Twinfilin OS=Aedes aegypti GN=twf PE=3 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular KOG1747 Protein tyrosine kinase 9/actin monomer-binding protein Cluster-8309.41667 BF_2 144.00 1.00 6293 91091970 XP_968583.1 1843 8.0e-203 PREDICTED: synaptotagmin-11 [Tribolium castaneum]>gi|270001306|gb|EEZ97753.1| synaptotagmin IV [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BT88 786 1.2e-81 Synaptotagmin-11 OS=Homo sapiens GN=SYT11 PE=1 SV=2 PF00168//PF03585 C2 domain//Herpesvirus ICP4-like protein C-terminal region GO:0045893//GO:0006810 positive regulation of transcription, DNA-templated//transport GO:0005215//GO:0005515 transporter activity//protein binding GO:0042025//GO:0016020//GO:0008021 host cell nucleus//membrane//synaptic vesicle KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41670 BF_2 836.00 21.83 1889 189240330 XP_001809949.1 1435 4.9e-156 PREDICTED: probable actin-related protein 2/3 complex subunit 2 [Tribolium castaneum] 533163901 XM_005395664.1 122 1.28794e-54 PREDICTED: Chinchilla lanigera actin related protein 2/3 complex, subunit 2, 34kDa (Arpc2), transcript variant X3, mRNA K05758 ARPC2 actin related protein 2/3 complex, subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05758 Q7PVX8 1305 2.4e-142 Probable actin-related protein 2/3 complex subunit 2 OS=Anopheles gambiae GN=Arc-p34 PE=3 SV=2 PF04045//PF05856 Arp2/3 complex, 34 kD subunit p34-Arc//ARP2/3 complex 20 kDa subunit (ARPC4) GO:0030833//GO:0030041//GO:0034314 regulation of actin filament polymerization//actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005885//GO:0015629 Arp2/3 protein complex//actin cytoskeleton KOG2826 Actin-related protein Arp2/3 complex, subunit ARPC2 Cluster-8309.41672 BF_2 12.00 6.65 359 -- -- -- -- -- 514833854 KC795683.1 267 5.62625e-136 Scylla paramamosain beta-actin mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41673 BF_2 399.00 8.04 2364 110617755 ABG78596.1 1805 7.7e-199 beta-actin [Mizuhopecten yessoensis] 514833854 KC795683.1 912 0 Scylla paramamosain beta-actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 Q26065 1796 3.5e-199 Actin, adductor muscle OS=Placopecten magellanicus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.41674 BF_2 224.69 2.49 4068 546683519 ERL93321.1 210 1.2e-13 hypothetical protein D910_10615 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus -- -- Cluster-8309.41675 BF_2 44.24 0.54 3730 649572255 NP_001280540.1 1336 2.9e-144 FMRFamide receptor [Tribolium castaneum]>gi|91078222|ref|XP_969392.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915085|ref|XP_008190406.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915087|ref|XP_008190407.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|270002872|gb|EEZ99319.1| hypothetical protein TcasGA2_TC001381 [Tribolium castaneum]>gi|485836781|tpg|DAA64478.1| TPA_inf: FMRFamide-like G protein-coupled receptor [Tribolium castaneum] 158301538 XM_321207.2 76 9.55882e-29 Anopheles gambiae str. PEST AGAP001862-PA (GPRNNA1) mRNA, complete cds -- -- -- -- Q9VZW5 891 4.8e-94 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.41677 BF_2 949.55 4.98 8262 91079350 XP_969694.1 3799 0.0e+00 PREDICTED: lysosomal alpha-glucosidase-like [Tribolium castaneum] -- -- -- -- -- K12316 GAA lysosomal alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12316 Q6P7A9 2110 4.7e-235 Lysosomal alpha-glucosidase OS=Rattus norvegicus GN=Gaa PE=2 SV=1 PF01055//PF00096//PF13465//PF13912//PF02892 Glycosyl hydrolases family 31//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BED zinc finger GO:0005975 carbohydrate metabolic process GO:0046872//GO:0004553//GO:0003677 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding -- -- -- -- Cluster-8309.41680 BF_2 2610.01 11.82 9525 815914229 XP_012242394.1 2221 1.8e-246 PREDICTED: uncharacterized protein LOC100740589 isoform X1 [Bombus impatiens] 642918459 XM_008193262.1 304 4.42022e-155 PREDICTED: Tribolium castaneum FH1/FH2 domain-containing protein 3 (LOC659452), transcript variant X5, mRNA -- -- -- -- Q76LL6 1232 3.5e-133 FH1/FH2 domain-containing protein 3 OS=Mus musculus GN=Fhod3 PE=1 SV=1 PF00895//PF01059 ATP synthase protein 8//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0055114//GO:0015992//GO:0006120//GO:0015986 oxidation-reduction process//proton transport//mitochondrial electron transport, NADH to ubiquinone//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG1925 Rac1 GTPase effector FHOS Cluster-8309.41681 BF_2 143.44 4.48 1627 270008756 EFA05204.1 538 4.4e-52 hypothetical protein TcasGA2_TC015340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49327 291 7.9e-25 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF00025//PF00975//PF16093 ADP-ribosylation factor family//Thioesterase domain//Proteasome assembly chaperone 4 GO:0009058//GO:0043248 biosynthetic process//proteasome assembly GO:0005525//GO:0016788 GTP binding//hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.41682 BF_2 62.32 0.96 3007 546684533 ERL94164.1 1157 1.3e-123 hypothetical protein D910_11446, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.41685 BF_2 352.23 0.95 15775 546679672 ERL90099.1 6770 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 3978 0.0e+00 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF00462//PF13176//PF13414//PF13374//PF00515//PF00018//PF14604//PF02737//PF08141//PF00389//PF03493//PF02826//PF03446//PF13181 Glutaredoxin//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//SH3 domain//Variant SH3 domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Small acid-soluble spore protein H family//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Tetratricopeptide repeat GO:0006631//GO:0006552//GO:0045454//GO:0008152//GO:0018874//GO:0006633//GO:0006098//GO:0006813//GO:0006568//GO:0019521//GO:0006118//GO:0030436//GO:0006554//GO:0055114//GO:0006574//GO:0006550 fatty acid metabolic process//leucine catabolic process//cell redox homeostasis//metabolic process//benzoate metabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//potassium ion transport//tryptophan metabolic process//D-gluconate metabolic process//obsolete electron transport//asexual sporulation//lysine catabolic process//oxidation-reduction process//valine catabolic process//isoleucine catabolic process GO:0015035//GO:0009055//GO:0016491//GO:0005515//GO:0051287//GO:0003857//GO:0004616//GO:0015269//GO:0016616 protein disulfide oxidoreductase activity//electron carrier activity//oxidoreductase activity//protein binding//NAD binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity//calcium-activated potassium channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016020//GO:0042601 membrane//endospore-forming forespore KOG1998 Signaling protein DOCK180 Cluster-8309.41686 BF_2 449.25 3.23 6099 91092316 XP_970010.1 1371 4.2e-148 PREDICTED: beta-1,3-glucan-binding protein [Tribolium castaneum]>gi|270015726|gb|EFA12174.1| Gram-negative bacteria binding protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76DI2 1247 4.1e-135 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF15886//PF00722 Carbohydrate binding domain (family 32)//Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.41688 BF_2 61.77 1.00 2866 189237332 XP_973384.2 1523 4.7e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 83 9.40622e-33 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.4e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.41689 BF_2 1489.34 15.81 4228 478253821 ENN74113.1 4477 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 107 6.34634e-46 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3293 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF16656//PF01618//PF00041//PF13895 Purple acid Phosphatase, N-terminal domain//MotA/TolQ/ExbB proton channel family//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0015031//GO:0006810//GO:0019497 riboflavin metabolic process//protein transport//transport//hexachlorocyclohexane metabolic process GO:0003993//GO:0008565//GO:0046872//GO:0005515 acid phosphatase activity//protein transporter activity//metal ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.41692 BF_2 867.00 10.53 3730 815792875 XP_012217045.1 986 1.1e-103 PREDICTED: splicing factor U2af 38 kDa subunit-like [Linepithema humile] 642933804 XM_964331.2 254 1.07337e-127 PREDICTED: Tribolium castaneum splicing factor U2af 38 kDa subunit (LOC657904), mRNA K12836 U2AF1 splicing factor U2AF 35 kDa subunit http://www.genome.jp/dbget-bin/www_bget?ko:K12836 Q94535 955 1.8e-101 Splicing factor U2af 38 kDa subunit OS=Drosophila melanogaster GN=U2af38 PE=1 SV=2 PF00642//PF02954//PF00076 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Bacterial regulatory protein, Fis family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0043565//GO:0046872 nucleic acid binding//sequence-specific DNA binding//metal ion binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.41693 BF_2 877.53 3.94 9604 642926098 XP_008194783.1 5696 0.0e+00 PREDICTED: uncharacterized protein KIAA1109 [Tribolium castaneum] 755951836 XM_011303587.1 50 7.02857e-14 PREDICTED: Fopius arisanus uncharacterized protein KIAA1109 (LOC105265834), transcript variant X9, mRNA -- -- -- -- A2AAE1 1928 7.0e-214 Uncharacterized protein KIAA1109 OS=Mus musculus GN=Kiaa1109 PE=1 SV=4 PF08093//PF11815 Magi 5 toxic peptide family//Domain of unknown function (DUF3336) GO:0009405//GO:0006810//GO:0006629//GO:0016042//GO:0046486 pathogenesis//transport//lipid metabolic process//lipid catabolic process//glycerolipid metabolic process GO:0004806//GO:0019871 triglyceride lipase activity//sodium channel inhibitor activity GO:0005576 extracellular region KOG3596 Uncharacterized conserved protein Cluster-8309.41694 BF_2 114.66 0.37 13363 270007741 EFA04189.1 2015 1.9e-222 hypothetical protein TcasGA2_TC014438 [Tribolium castaneum] 642923854 XM_008195685.1 221 8.55884e-109 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC663619), mRNA K11974 RNF31 E3 ubiquitin-protein ligase RNF31 http://www.genome.jp/dbget-bin/www_bget?ko:K11974 Q96EP0 878 5.5e-92 E3 ubiquitin-protein ligase RNF31 OS=Homo sapiens GN=RNF31 PE=1 SV=1 PF00096//PF05495//PF13806//PF07776//PF01426//PF05121//PF13465//PF07975//PF00412//PF00641//PF13912//PF09182//PF02845//PF08273 Zinc finger, C2H2 type//CHY zinc finger//Rieske-like [2Fe-2S] domain//Zinc-finger associated domain (zf-AD)//BAH domain//Gas vesicle protein K//Zinc-finger double domain//TFIIH C1-like domain//LIM domain//Zn-finger in Ran binding protein and others//C2H2-type zinc finger//Bacterial purine repressor, N-terminal//CUE domain//Zinc-binding domain of primase-helicase GO:0006281//GO:0031412//GO:0055114//GO:0006269//GO:0006355//GO:0042128//GO:0006351//GO:0006807 DNA repair//gas vesicle organization//oxidation-reduction process//DNA replication, synthesis of RNA primer//regulation of transcription, DNA-templated//nitrate assimilation//transcription, DNA-templated//nitrogen compound metabolic process GO:0003896//GO:0003682//GO:0008942//GO:0008270//GO:0005515//GO:0003677//GO:0004386//GO:0046872 DNA primase activity//chromatin binding//nitrite reductase [NAD(P)H] activity//zinc ion binding//protein binding//DNA binding//helicase activity//metal ion binding GO:0005730//GO:0005657//GO:0000785//GO:0005634 nucleolus//replication fork//chromatin//nucleus -- -- Cluster-8309.41695 BF_2 1209.13 15.61 3528 642938247 XP_008198128.1 619 3.8e-61 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 58 9.16487e-19 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 494 4.9e-48 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF17096//PF02932//PF01080//PF03293//PF07714//PF00069 Altered inheritance of mitochondria protein 3//Neurotransmitter-gated ion-channel transmembrane region//Presenilin//Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0019083//GO:0006811//GO:0006206//GO:0051016//GO:0006144//GO:0006351 protein phosphorylation//viral transcription//ion transport//pyrimidine nucleobase metabolic process//barbed-end actin filament capping//purine nucleobase metabolic process//transcription, DNA-templated GO:0003899//GO:0005524//GO:0004672//GO:0004190//GO:0003677 DNA-directed RNA polymerase activity//ATP binding//protein kinase activity//aspartic-type endopeptidase activity//DNA binding GO:0005730//GO:0030479//GO:0016021//GO:0016020 nucleolus//actin cortical patch//integral component of membrane//membrane KOG0671 LAMMER dual specificity kinases Cluster-8309.41696 BF_2 2233.00 88.47 1343 642920456 XP_975647.2 1257 1.5e-135 PREDICTED: eukaryotic translation initiation factor 3 subunit F-1 [Tribolium castaneum] -- -- -- -- -- K03249 EIF3F translation initiation factor 3 subunit F http://www.genome.jp/dbget-bin/www_bget?ko:K03249 B4JGX4 1127 7.4e-122 Eukaryotic translation initiation factor 3 subunit F-1 OS=Drosophila grimshawi GN=eIF3-S5-1 PE=3 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- KOG2975 Translation initiation factor 3, subunit f (eIF-3f) Cluster-8309.41698 BF_2 165.91 1.22 5958 189233727 XP_970593.2 2849 0.0e+00 PREDICTED: AP-3 complex subunit beta-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12397 AP3B AP-3 complex subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K12397 Q13367 2085 2.7e-232 AP-3 complex subunit beta-2 OS=Homo sapiens GN=AP3B2 PE=1 SV=2 PF02985//PF02535//PF13374//PF02862//PF00515//PF09726//PF13371//PF00330//PF02486//PF13414//PF13181//PF13174//PF08492//PF01602 HEAT repeat//ZIP Zinc transporter//Tetratricopeptide repeat//DDHD domain//Tetratricopeptide repeat//Transmembrane protein//Tetratricopeptide repeat//Aconitase family (aconitate hydratase)//Replication initiation factor//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//SRP72 RNA-binding domain//Adaptin N terminal region GO:0055085//GO:0006614//GO:0006270//GO:0016192//GO:0006886//GO:0006265//GO:0008152//GO:0030001 transmembrane transport//SRP-dependent cotranslational protein targeting to membrane//DNA replication initiation//vesicle-mediated transport//intracellular protein transport//DNA topological change//metabolic process//metal ion transport GO:0003677//GO:0005515//GO:0003916//GO:0046873//GO:0008312//GO:0046872 DNA binding//protein binding//DNA topoisomerase activity//metal ion transmembrane transporter activity//7S RNA binding//metal ion binding GO:0016021//GO:0048500//GO:0016020//GO:0030117 integral component of membrane//signal recognition particle//membrane//membrane coat KOG1060 Vesicle coat complex AP-3, beta subunit Cluster-8309.41699 BF_2 237.83 6.42 1837 642928935 XP_008195623.1 1413 1.7e-153 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9VCX1 836 5.6e-88 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF02196//PF00788 Raf-like Ras-binding domain//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- -- -- Cluster-8309.41701 BF_2 679.00 14.82 2204 91082953 XP_973566.1 1613 1.3e-176 PREDICTED: pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 [Tribolium castaneum]>gi|270007627|gb|EFA04075.1| hypothetical protein TcasGA2_TC014309 [Tribolium castaneum] -- -- -- -- -- K16174 MRPS18B, MRPS18-2 small subunit ribosomal protein S18b, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16174 Q68FS6 1003 2.9e-107 Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 OS=Rattus norvegicus GN=Pyroxd1 PE=2 SV=1 PF01266//PF05834//PF07992//PF01084//PF00070//PF01593 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Ribosomal protein S18//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase GO:0042254//GO:0055114//GO:0016117//GO:0006412 ribosome biogenesis//oxidation-reduction process//carotenoid biosynthetic process//translation GO:0003735//GO:0016491//GO:0016705 structural constituent of ribosome//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0005622//GO:0005840 intracellular//ribosome KOG4021 Mitochondrial ribosomal protein S18b Cluster-8309.41703 BF_2 35.47 1.04 1720 642919151 XP_008191758.1 383 4.3e-34 PREDICTED: sortilin-related receptor-like [Tribolium castaneum]>gi|270005745|gb|EFA02193.1| hypothetical protein TcasGA2_TC007849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04345//PF00041 Chorismate lyase//Fibronectin type III domain GO:0006744 ubiquinone biosynthetic process GO:0005515//GO:0008813 protein binding//chorismate lyase activity GO:0005737 cytoplasm -- -- Cluster-8309.41707 BF_2 53.59 1.78 1550 546676039 ERL87122.1 159 3.7e-08 hypothetical protein D910_04522 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17121 Zinc finger, C3HC4 type (RING finger) -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- -- -- Cluster-8309.41709 BF_2 13.22 0.38 1755 827545095 XP_012545127.1 529 5.2e-51 PREDICTED: uncharacterized protein LOC105841501 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01165 Ribosomal protein S21 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.41712 BF_2 58.90 0.59 4431 642928504 XP_008193818.1 3415 0.0e+00 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGW4 1340 4.9e-146 Endoplasmic reticulum metallopeptidase 1 OS=Xenopus laevis GN=ermp1 PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.41714 BF_2 39.93 11.49 432 568599616 AHE13803.1 289 8.6e-24 chemosensory protein 8 [Lissorhoptrus oryzophilus] 817185798 XM_012431951.1 64 4.84231e-23 PREDICTED: Orussus abietinus ejaculatory bulb-specific protein 3-like (LOC105703508), mRNA -- -- -- -- Q9W1C9 252 6.9e-21 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41715 BF_2 27.67 0.31 4013 329762926 AEC04844.1 324 7.0e-27 chemosensory protein [Batocera horsfieldi] 329762925 HQ587042.1 188 5.64945e-91 Batocera horsfieldi chemosensory protein (CSP3) mRNA, complete cds -- -- -- -- Q9W1C9 185 3.8e-12 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41717 BF_2 2.80 0.46 543 568599616 AHE13803.1 289 1.1e-23 chemosensory protein 8 [Lissorhoptrus oryzophilus] 817185798 XM_012431951.1 64 6.17534e-23 PREDICTED: Orussus abietinus ejaculatory bulb-specific protein 3-like (LOC105703508), mRNA -- -- -- -- Q9W1C9 252 8.7e-21 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41718 BF_2 1032.31 43.19 1287 642935880 XP_008198210.1 435 3.0e-40 PREDICTED: uncharacterized protein LOC103314310 [Tribolium castaneum] 642935879 XM_008199988.1 39 1.19904e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103314310 (LOC103314310), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41719 BF_2 359.31 6.69 2534 642923805 XP_008193890.1 1839 9.4e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 5.0e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0003723//GO:0000166 nucleic acid binding//RNA binding//nucleotide binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41720 BF_2 40.25 0.49 3736 642923805 XP_008193890.1 1839 1.4e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 7.3e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41721 BF_2 128.38 1.43 4050 642923805 XP_008193890.1 1839 1.5e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 7.9e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41722 BF_2 90.20 1.95 2222 642923805 XP_008193890.1 1839 8.2e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 4.4e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.41725 BF_2 2453.09 16.70 6431 642924727 XP_008194417.1 3076 0.0e+00 PREDICTED: RB1-inducible coiled-coil protein 1 isoform X4 [Tribolium castaneum] 642924726 XM_008196195.1 59 4.66435e-19 PREDICTED: Tribolium castaneum RB1-inducible coiled-coil protein 1 (LOC663996), transcript variant X7, mRNA K17589 RB1CC1 RB1-inducible coiled-coil protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17589 Q9HC24 552 1.7e-54 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 PF11057 Cortexin of kidney -- -- -- -- GO:0031224 intrinsic component of membrane KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.41728 BF_2 127.93 0.66 8427 270006717 EFA03165.1 2578 6.3e-288 hypothetical protein TcasGA2_TC013085 [Tribolium castaneum] 642924726 XM_008196195.1 59 6.12042e-19 PREDICTED: Tribolium castaneum RB1-inducible coiled-coil protein 1 (LOC663996), transcript variant X7, mRNA K17589 RB1CC1 RB1-inducible coiled-coil protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17589 Q9HC24 552 2.2e-54 Protein lifeguard 4 OS=Homo sapiens GN=TMBIM4 PE=1 SV=3 PF11057//PF04310 Cortexin of kidney//MukB N-terminal GO:0030261//GO:0007059 chromosome condensation//chromosome segregation GO:0003677//GO:0005524 DNA binding//ATP binding GO:0031224//GO:0009295 intrinsic component of membrane//nucleoid KOG2322 N-methyl-D-aspartate receptor glutamate-binding subunit Cluster-8309.41730 BF_2 24.00 1.23 1104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41731 BF_2 181.20 1.49 5378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01635//PF03014 Coronavirus M matrix/glycoprotein//Structural protein 2 GO:0019058 viral life cycle GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.41733 BF_2 30.98 0.35 4003 237681143 NP_001153714.1 3081 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 1.70563e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2398 9.2e-269 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00645//PF02877//PF00644//PF08063 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase, regulatory domain//Poly(ADP-ribose) polymerase catalytic domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0003677//GO:0008270//GO:0003950 DNA binding//zinc ion binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41734 BF_2 533.87 4.27 5520 237681143 NP_001153714.1 3231 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 2.35787e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2522 5.3e-283 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00645//PF02877//PF00644//PF08063 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase, regulatory domain//Poly(ADP-ribose) polymerase catalytic domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0003677//GO:0008270//GO:0003950 DNA binding//zinc ion binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41735 BF_2 43.95 0.32 6018 237681143 NP_001153714.1 3231 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 2.57199e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2522 5.8e-283 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00645//PF00644//PF02877//PF08063 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase catalytic domain//Poly(ADP-ribose) polymerase, regulatory domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0003950//GO:0003677//GO:0008270 NAD+ ADP-ribosyltransferase activity//DNA binding//zinc ion binding GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41736 BF_2 423.76 5.70 3398 270004713 EFA01161.1 1361 3.4e-147 hypothetical protein TcasGA2_TC010386 [Tribolium castaneum] 828210619 XM_004208630.2 127 3.87937e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1213 2.0e-131 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF07714//PF06293//PF00069//PF09573 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//TaqI restriction endonuclease GO:0006308//GO:0009307//GO:0006468 DNA catabolic process//DNA restriction-modification system//protein phosphorylation GO:0004672//GO:0016773//GO:0009036//GO:0003677//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//Type II site-specific deoxyribonuclease activity//DNA binding//ATP binding GO:0016020//GO:0009359 membrane//Type II site-specific deoxyribonuclease complex KOG4717 Serine/threonine protein kinase Cluster-8309.41738 BF_2 138.92 6.96 1122 189237587 XP_975066.2 639 5.8e-64 PREDICTED: nuclear cap-binding protein subunit 2 [Tribolium castaneum] 755860540 XM_005178495.2 59 7.94432e-20 PREDICTED: Musca domestica nuclear cap-binding protein subunit 2B (LOC101888112), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 577 3.7e-58 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.41739 BF_2 209.90 2.12 4427 189237587 XP_975066.2 695 7.4e-70 PREDICTED: nuclear cap-binding protein subunit 2 [Tribolium castaneum] 755860540 XM_005178495.2 76 1.13624e-28 PREDICTED: Musca domestica nuclear cap-binding protein subunit 2B (LOC101888112), mRNA K12883 NCBP2, CBP20 nuclear cap-binding protein subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12883 Q1HE01 629 1.4e-63 Nuclear cap-binding protein subunit 2 OS=Bombyx mori PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0121 Nuclear cap-binding protein complex, subunit CBP20 (RRM superfamily) Cluster-8309.41740 BF_2 247.06 2.08 5244 642924396 XP_008194278.1 1678 9.1e-184 PREDICTED: mitotic checkpoint serine/threonine-protein kinase BUB1 beta [Tribolium castaneum] -- -- -- -- -- K02178 BUB1 checkpoint serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K02178 O43683 451 7.1e-43 Mitotic checkpoint serine/threonine-protein kinase BUB1 OS=Homo sapiens GN=BUB1 PE=1 SV=1 PF07714//PF00541//PF00069//PF03852 Protein tyrosine kinase//Adenoviral fibre protein (knob domain)//Protein kinase domain//DNA mismatch endonuclease Vsr GO:0006298//GO:0019062//GO:0006468 mismatch repair//virion attachment to host cell//protein phosphorylation GO:0005524//GO:0004519//GO:0004672 ATP binding//endonuclease activity//protein kinase activity GO:0019028 viral capsid KOG1166 Mitotic checkpoint serine/threonine protein kinase Cluster-8309.41743 BF_2 612.63 9.47 2992 642917967 XP_008198963.1 3830 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] 766925232 XM_011496200.1 153 1.20101e-71 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1847 5.4e-205 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF12831//PF00070//PF01266//PF07992 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0006563//GO:0006566//GO:0006546//GO:0006544//GO:0055114 L-serine metabolic process//threonine metabolic process//glycine catabolic process//glycine metabolic process//oxidation-reduction process GO:0016491//GO:0004047 oxidoreductase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.41744 BF_2 29.94 0.45 3059 642917967 XP_008198963.1 3569 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] 766925232 XM_011496200.1 159 5.67414e-75 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1745 3.7e-193 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF00070//PF12831//PF07992//PF01266 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase GO:0006563//GO:0055114//GO:0006546//GO:0006544//GO:0006566 L-serine metabolic process//oxidation-reduction process//glycine catabolic process//glycine metabolic process//threonine metabolic process GO:0016491//GO:0004047 oxidoreductase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.41747 BF_2 180.41 1.48 5373 642937954 XP_008199143.1 2954 0.0e+00 PREDICTED: isoleucine--tRNA ligase, mitochondrial [Tribolium castaneum] 571578376 XM_006572314.1 45 2.36053e-11 PREDICTED: Apis mellifera isoleucyl-tRNA synthetase, mitochondrial-like (LOC726483), partial mRNA K01870 IARS, ileS isoleucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01870 Q9NSE4 1916 9.6e-213 Isoleucine--tRNA ligase, mitochondrial OS=Homo sapiens GN=IARS2 PE=1 SV=2 PF10473//PF08264//PF00133//PF09334 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Anticodon-binding domain of tRNA//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0006418 tRNA aminoacylation for protein translation GO:0045502//GO:0008134//GO:0005524//GO:0004812//GO:0000166//GO:0042803 dynein binding//transcription factor binding//ATP binding//aminoacyl-tRNA ligase activity//nucleotide binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex KOG0433 Isoleucyl-tRNA synthetase Cluster-8309.41749 BF_2 683.25 6.94 4408 91093203 XP_969368.1 999 4.1e-105 PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|642938151|ref|XP_008199786.1| PREDICTED: neurocalcin homolog [Tribolium castaneum]>gi|270016483|gb|EFA12929.1| hypothetical protein TcasGA2_TC010475 [Tribolium castaneum] 170043832 XM_001849523.1 373 0 Culex quinquefasciatus hippocalcin, mRNA -- -- -- -- P42325 984 9.3e-105 Neurocalcin homolog OS=Drosophila melanogaster GN=Nca PE=1 SV=2 PF13499//PF02745//PF13833//PF10591//PF13405//PF11095//PF12763//PF00036//PF13202 EF-hand domain pair//Methyl-coenzyme M reductase alpha subunit, N-terminal domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Gem-associated protein 7 (Gemin7)//Cytoskeletal-regulatory complex EF hand//EF hand//EF hand GO:0046656//GO:0007165//GO:0015948 folic acid biosynthetic process//signal transduction//methanogenesis GO:0005515//GO:0050524//GO:0005509 protein binding//coenzyme-B sulfoethylthiotransferase activity//calcium ion binding GO:0032797//GO:0005578 SMN complex//proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.41752 BF_2 3.00 2.33 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41753 BF_2 502.84 16.87 1534 478254694 ENN74935.1 403 1.9e-36 hypothetical protein YQE_08513, partial [Dendroctonus ponderosae] 768418772 XM_011551784.1 53 2.36851e-16 PREDICTED: Plutella xylostella uncharacterized LOC105381973 (LOC105381973), mRNA -- -- -- -- -- -- -- -- PF06936 Selenoprotein S (SelS) GO:0006886 intracellular protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.41755 BF_2 49.82 0.72 3184 478251864 ENN72303.1 1127 4.3e-120 hypothetical protein YQE_11046, partial [Dendroctonus ponderosae]>gi|546674377|gb|ERL85764.1| hypothetical protein D910_03179 [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 2.1e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.41756 BF_2 1334.60 6.76 8552 642935792 XP_008198176.1 4758 0.0e+00 PREDICTED: nitric oxide synthase, salivary gland isoform X2 [Tribolium castaneum] 148367285 AB304919.1 233 1.16718e-115 Luciola lateralis LlNOS mRNA for nitric oxide synthase, complete cds K13240 NOS1 nitric-oxide synthase, brain http://www.genome.jp/dbget-bin/www_bget?ko:K13240 B1B557 3625 0.0e+00 Nitric oxide synthase-like protein OS=Bombyx mori GN=NSL PE=2 SV=1 PF10505//PF00667//PF04103//PF02898//PF00802//PF00175//PF01040//PF00258//PF09570//PF00335//PF01384 NMDA receptor-regulated gene protein 2 C-terminus//FAD binding domain//CD20-like family//Nitric oxide synthase, oxygenase domain//Pneumovirus attachment glycoprotein G//Oxidoreductase NAD-binding domain//UbiA prenyltransferase family//Flavodoxin//SinI restriction endonuclease//Tetraspanin family//Phosphate transporter family GO:0006308//GO:0009307//GO:0055114//GO:0006817//GO:0006809 DNA catabolic process//DNA restriction-modification system//oxidation-reduction process//phosphate ion transport//nitric oxide biosynthetic process GO:0003677//GO:0009036//GO:0016491//GO:0005315//GO:0010181//GO:0004517//GO:0004659 DNA binding//Type II site-specific deoxyribonuclease activity//oxidoreductase activity//inorganic phosphate transmembrane transporter activity//FMN binding//nitric-oxide synthase activity//prenyltransferase activity GO:0009359//GO:0016020//GO:0008023//GO:0016021//GO:0055036 Type II site-specific deoxyribonuclease complex//membrane//transcription elongation factor complex//integral component of membrane//virion membrane KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.41757 BF_2 1202.11 8.71 6062 642925796 XP_008190317.1 6340 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 50 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULJ7 1763 6.0e-195 Ankyrin repeat domain-containing protein 50 OS=Homo sapiens GN=ANKRD50 PE=1 SV=4 PF01279//PF01331//PF09266//PF00023//PF13606 Parathyroid hormone family//mRNA capping enzyme, catalytic domain//Viral DNA topoisomerase I, N-terminal//Ankyrin repeat//Ankyrin repeat GO:0007165//GO:0006397//GO:0006370//GO:0006265 signal transduction//mRNA processing//7-methylguanosine mRNA capping//DNA topological change GO:0003677//GO:0003916//GO:0005179//GO:0004484//GO:0005515 DNA binding//DNA topoisomerase activity//hormone activity//mRNA guanylyltransferase activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.41758 BF_2 1.00 3.32 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41760 BF_2 270.45 3.39 3622 91094595 XP_970633.1 1466 2.4e-159 PREDICTED: cytochrome P450 6k1 [Tribolium castaneum]>gi|270016411|gb|EFA12857.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 966 9.4e-103 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0046872//GO:0016705 heme binding//oxidoreductase activity//iron ion binding//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.41763 BF_2 61.59 0.35 7662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41764 BF_2 463.00 22.60 1144 765141696 XP_011482082.1 415 5.6e-38 PREDICTED: polyubiquitin-C [Oryzias latipes] 568815687 NM_001288669.1 98 1.69344e-41 Solanum tuberosum ubiquitin-40S ribosomal protein S27a-like (LOC102593024), mRNA >gnl|BL_ORD_ID|2726171 Solanum tuberosum clone 068E12 ubiquitin extension protein-like protein mRNA, complete cds K04551 UBB ubiquitin B http://www.genome.jp/dbget-bin/www_bget?ko:K04551 P0CG54 412 5.1e-39 Polyubiquitin-B OS=Cavia porcellus GN=UBB PE=2 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.41766 BF_2 3.00 0.46 559 861633328 KMQ90923.1 292 5.0e-24 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41767 BF_2 204.19 5.13 1951 642925227 XP_008194475.1 739 2.6e-75 PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum]>gi|642925229|ref|XP_008194476.1| PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HA38 178 1.2e-11 Zinc finger matrin-type protein 3 OS=Homo sapiens GN=ZMAT3 PE=1 SV=1 PF06220//PF12753//PF04988 U1 zinc finger//Nuclear pore complex subunit Nro1//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0003677//GO:0008270//GO:0005515 DNA binding//zinc ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.41769 BF_2 868.12 15.71 2599 91086813 XP_973672.1 1182 1.5e-126 PREDICTED: neutral and basic amino acid transport protein rBAT [Tribolium castaneum]>gi|270010450|gb|EFA06898.1| hypothetical protein TcasGA2_TC009845 [Tribolium castaneum] -- -- -- -- -- K06519 SLC3A2, MDU1 solute carrier family 3, member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06519 O16098 254 2.4e-20 Maltase 1 OS=Drosophila virilis GN=Mal-B1 PE=3 SV=2 PF00128//PF00763 Alpha amylase, catalytic domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0009396//GO:0046487//GO:0005975//GO:0055114 folic acid-containing compound biosynthetic process//glyoxylate metabolic process//carbohydrate metabolic process//oxidation-reduction process GO:0043169//GO:0003824//GO:0004488 cation binding//catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG0471 Alpha-amylase Cluster-8309.41770 BF_2 19.73 0.41 2293 91086813 XP_973672.1 233 1.4e-16 PREDICTED: neutral and basic amino acid transport protein rBAT [Tribolium castaneum]>gi|270010450|gb|EFA06898.1| hypothetical protein TcasGA2_TC009845 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41771 BF_2 58.72 1.28 2205 91086813 XP_973672.1 221 3.4e-15 PREDICTED: neutral and basic amino acid transport protein rBAT [Tribolium castaneum]>gi|270010450|gb|EFA06898.1| hypothetical protein TcasGA2_TC009845 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41772 BF_2 12.65 0.51 1332 91079320 XP_967967.1 641 4.1e-64 PREDICTED: probable DNA-3-methyladenine glycosylase [Tribolium castaneum]>gi|270004337|gb|EFA00785.1| hypothetical protein TcasGA2_TC003671 [Tribolium castaneum] -- -- -- -- -- K03652 MPG DNA-3-methyladenine glycosylase http://www.genome.jp/dbget-bin/www_bget?ko:K03652 Q04841 455 6.2e-44 DNA-3-methyladenine glycosylase OS=Mus musculus GN=Mpg PE=2 SV=3 PF02245 Methylpurine-DNA glycosylase (MPG) GO:0006284 base-excision repair GO:0003677//GO:0003905 DNA binding//alkylbase DNA N-glycosylase activity -- -- -- -- Cluster-8309.41773 BF_2 29.58 0.42 3247 91079026 XP_974912.1 554 1.2e-53 PREDICTED: rap1 GTPase-GDP dissociation stimulator 1-B [Tribolium castaneum]>gi|270003670|gb|EFA00118.1| hypothetical protein TcasGA2_TC002934 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52306 138 8.6e-07 Rap1 GTPase-GDP dissociation stimulator 1 OS=Homo sapiens GN=RAP1GDS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41780 BF_2 518.04 21.61 1290 189235252 XP_971328.2 926 3.5e-97 PREDICTED: ubiquitin-conjugating enzyme E2-22 kDa [Tribolium castaneum]>gi|270004126|gb|EFA00574.1| hypothetical protein TcasGA2_TC003444 [Tribolium castaneum] 642916082 XM_966235.3 191 3.83301e-93 PREDICTED: Tribolium castaneum ubiquitin-conjugating enzyme E2-22 kDa (LOC659971), mRNA K04649 HIP2, UBC1 ubiquitin-conjugating enzyme (huntingtin interacting protein 2) http://www.genome.jp/dbget-bin/www_bget?ko:K04649 P52486 799 7.7e-84 Ubiquitin-conjugating enzyme E2-22 kDa OS=Drosophila melanogaster GN=UbcD4 PE=1 SV=2 PF02845//PF05773//PF15461//PF05743 CUE domain//RWD domain//Beta-carotene 15,15'-dioxygenase//UEV domain GO:0006464//GO:0015031//GO:0055114 cellular protein modification process//protein transport//oxidation-reduction process GO:0016881//GO:0005515//GO:0016702 acid-amino acid ligase activity//protein binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen -- -- KOG0418 Ubiquitin-protein ligase Cluster-8309.41781 BF_2 1.00 10.11 233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41782 BF_2 42.31 1.02 2030 270004122 EFA00570.1 324 3.5e-27 hypothetical protein TcasGA2_TC003440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.41783 BF_2 54.60 0.50 4890 357619286 EHJ71921.1 431 3.3e-39 hypothetical protein KGM_05158 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.41784 BF_2 7.39 0.33 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41785 BF_2 320.14 3.87 3750 478255274 ENN75503.1 1875 9.3e-207 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.41786 BF_2 392.06 2.84 6069 642931864 XP_008196760.1 1314 1.7e-141 PREDICTED: myosin heavy chain, clone 203 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01465//PF04048//PF05929//PF04508 GRIP domain//Sec8 exocyst complex component specific domain//Phage capsid scaffolding protein (GPO) serine peptidase//Viral A-type inclusion protein repeat GO:0016032//GO:0015031//GO:0000042//GO:0006904//GO:0019069 viral process//protein transport//protein targeting to Golgi//vesicle docking involved in exocytosis//viral capsid assembly GO:0005515 protein binding GO:0000145 exocyst -- -- Cluster-8309.41787 BF_2 254.27 3.33 3483 642932705 XP_008196952.1 2372 2.0e-264 PREDICTED: HEAT repeat-containing protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R5R2 1236 4.4e-134 HEAT repeat-containing protein 6 OS=Pongo abelii GN=HEATR6 PE=2 SV=1 PF02985//PF01106//PF00514//PF01667 HEAT repeat//NifU-like domain//Armadillo/beta-catenin-like repeat//Ribosomal protein S27 GO:0042254//GO:0006412//GO:0016226 ribosome biogenesis//translation//iron-sulfur cluster assembly GO:0005506//GO:0003735//GO:0051536//GO:0005515 iron ion binding//structural constituent of ribosome//iron-sulfur cluster binding//protein binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.41789 BF_2 308.00 33.92 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41790 BF_2 126.60 0.79 7024 642915800 XP_008200083.1 1943 2.3e-214 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum] -- -- -- -- -- K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q62371 723 2.7e-74 Discoidin domain-containing receptor 2 OS=Mus musculus GN=Ddr2 PE=1 SV=2 PF00069//PF07714//PF09472 Protein kinase domain//Protein tyrosine kinase//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) GO:0006468//GO:0046656//GO:0015948 protein phosphorylation//folic acid biosynthetic process//methanogenesis GO:0004672//GO:0005524//GO:0030269 protein kinase activity//ATP binding//tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.41793 BF_2 66.00 2.84 1258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41794 BF_2 15.80 1.13 870 189240524 XP_971875.2 163 7.1e-09 PREDICTED: 60S ribosomal protein L3 [Tribolium castaneum]>gi|270011378|gb|EFA07826.1| hypothetical protein TcasGA2_TC005395 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O16797 143 6.1e-08 60S ribosomal protein L3 OS=Drosophila melanogaster GN=RpL3 PE=1 SV=3 -- -- GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0746 60S ribosomal protein L3 and related proteins Cluster-8309.41797 BF_2 83.35 1.96 2067 642927021 XP_008195106.1 1235 8.3e-133 PREDICTED: CREB-regulated transcription coactivator 1-like isoform X1 [Tribolium castaneum]>gi|642927023|ref|XP_008195107.1| PREDICTED: CREB-regulated transcription coactivator 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K15309 CRTC1, TORC1 CREB-regulated transcription coactivator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15309 Q68ED7 272 1.6e-22 CREB-regulated transcription coactivator 1 OS=Mus musculus GN=Crtc1 PE=1 SV=1 PF00170//PF12884//PF05145 bZIP transcription factor//Transducer of regulated CREB activity, N terminus//Putative ammonia monooxygenase GO:0010468//GO:0051289//GO:0006355 regulation of gene expression//protein homotetramerization//regulation of transcription, DNA-templated GO:0008140//GO:0003700//GO:0043565 cAMP response element binding protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0016021 transcription factor complex//integral component of membrane -- -- Cluster-8309.41799 BF_2 79.76 0.98 3695 642911809 XP_008200752.1 3666 0.0e+00 PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911811|ref|XP_008200753.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911813|ref|XP_008200754.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 1444 3.6e-158 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41800 BF_2 1145.83 5.17 9564 91082921 XP_972710.1 2880 0.0e+00 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] 462337062 APGK01037684.1 46 1.17121e-11 Dendroctonus ponderosae Seq01037694, whole genome shotgun sequence K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 2336 3.4e-261 Annulin OS=Schistocerca americana PE=2 SV=1 PF02417//PF00868//PF01347//PF00927//PF02150 Chromate transporter//Transglutaminase family//Lipoprotein amino terminal region//Transglutaminase family, C-terminal ig like domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0018149//GO:0006869//GO:0006144//GO:0006351//GO:0015703 pyrimidine nucleobase metabolic process//peptide cross-linking//lipid transport//purine nucleobase metabolic process//transcription, DNA-templated//chromate transport GO:0046872//GO:0003810//GO:0015109//GO:0005319//GO:0003899//GO:0003677 metal ion binding//protein-glutamine gamma-glutamyltransferase activity//chromate transmembrane transporter activity//lipid transporter activity//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.41801 BF_2 74.34 13.70 514 91082921 XP_972710.1 555 1.5e-54 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] -- -- -- -- -- K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 501 1.1e-49 Annulin OS=Schistocerca americana PE=2 SV=1 PF00927 Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810//GO:0046872 protein-glutamine gamma-glutamyltransferase activity//metal ion binding -- -- -- -- Cluster-8309.41802 BF_2 424.42 2.11 8696 91093513 XP_969441.1 4135 0.0e+00 PREDICTED: RNA polymerase-associated protein CTR9 homolog [Tribolium castaneum]>gi|270002675|gb|EEZ99122.1| hypothetical protein TcasGA2_TC005228 [Tribolium castaneum] 759065906 XM_011344092.1 652 0 PREDICTED: Cerapachys biroi RNA polymerase-associated protein CTR9 homolog (LOC105282240), mRNA K15176 CTR9 RNA polymerase-associated protein CTR9 http://www.genome.jp/dbget-bin/www_bget?ko:K15176 Q4QR29 3306 0.0e+00 RNA polymerase-associated protein CTR9 homolog OS=Xenopus laevis GN=ctr9 PE=2 SV=1 PF07721//PF13181//PF10579//PF13174//PF05009//PF00515//PF13374//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0016032//GO:0007268 viral process//synaptic transmission GO:0042802//GO:0033130//GO:0005515//GO:0043495 identical protein binding//acetylcholine receptor binding//protein binding//protein anchor GO:0042025 host cell nucleus KOG2002 TPR-containing nuclear phosphoprotein that regulates K(+) uptake Cluster-8309.41805 BF_2 569.55 6.37 4026 642921414 XP_008192856.1 2698 3.7e-302 PREDICTED: N-acetylgalactosaminyltransferase 7 [Tribolium castaneum]>gi|270006291|gb|EFA02739.1| hypothetical protein TcasGA2_TC008465 [Tribolium castaneum] 195447413 XM_002071167.1 186 7.33191e-90 Drosophila willistoni GK25256 (Dwil\GK25256), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MV48 2294 1.1e-256 N-acetylgalactosaminyltransferase 7 OS=Drosophila melanogaster GN=GalNAc-T2 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.41812 BF_2 17.53 0.36 2338 642930006 XP_008196062.1 318 2.0e-26 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 7.1e-19 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.41813 BF_2 173.29 10.18 999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41814 BF_2 1521.28 28.54 2517 826443936 XP_012530879.1 647 1.5e-64 PREDICTED: S-phase kinase-associated protein 1 [Monomorium pharaonis] 831287439 XM_012819624.1 139 6.11418e-64 PREDICTED: Clupea harengus S-phase kinase-associated protein 1 (skp1), mRNA K03094 SKP1, CBF3D S-phase kinase-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03094 Q71U00 564 2.7e-56 S-phase kinase-associated protein 1 OS=Xenopus laevis GN=skp1 PE=1 SV=3 PF00651//PF01466//PF03931 BTB/POZ domain//Skp1 family, dimerisation domain//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- KOG1724 SCF ubiquitin ligase, Skp1 component Cluster-8309.41817 BF_2 1588.78 24.75 2972 91089951 XP_973444.1 2134 6.8e-237 PREDICTED: ABC transporter G family member 20 [Tribolium castaneum]>gi|270013551|gb|EFA09999.1| hypothetical protein TcasGA2_TC012169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q55EH8 694 2.7e-71 ABC transporter G family member 23 OS=Dictyostelium discoideum GN=abcG23 PE=3 SV=2 PF00931//PF13304//PF00006//PF01637//PF01061//PF03193//PF00005 NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//ABC-2 type transporter//Protein of unknown function, DUF258//ABC transporter -- -- GO:0043531//GO:0003924//GO:0005524//GO:0005525//GO:0000166//GO:0016887 ADP binding//GTPase activity//ATP binding//GTP binding//nucleotide binding//ATPase activity GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.41818 BF_2 29.55 0.58 2435 478252139 ENN72569.1 550 2.6e-53 hypothetical protein YQE_10794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TXI4 140 3.8e-07 DNA double-strand break repair Rad50 ATPase OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=rad50 PE=3 SV=1 PF09730//PF06315//PF04111//PF06009//PF00769//PF05557//PF02050//PF06160//PF07926 Microtubule-associated protein Bicaudal-D//Isocitrate dehydrogenase kinase/phosphatase (AceK)//Autophagy protein Apg6//Laminin Domain II//Ezrin/radixin/moesin family//Mitotic checkpoint protein//Flagellar FliJ protein//Septation ring formation regulator, EzrA//TPR/MLP1/MLP2-like protein GO:0007094//GO:0007155//GO:0006935//GO:0006006//GO:0000921//GO:0071973//GO:0006606//GO:0006810//GO:0006914 mitotic spindle assembly checkpoint//cell adhesion//chemotaxis//glucose metabolic process//septin ring assembly//bacterial-type flagellum-dependent cell motility//protein import into nucleus//transport//autophagy GO:0008772//GO:0003774//GO:0008092//GO:0016791 [isocitrate dehydrogenase (NADP+)] kinase activity//motor activity//cytoskeletal protein binding//phosphatase activity GO:0016020//GO:0009288//GO:0005737//GO:0019898//GO:0016021//GO:0005940//GO:0005794 membrane//bacterial-type flagellum//cytoplasm//extrinsic component of membrane//integral component of membrane//septin ring//Golgi apparatus -- -- Cluster-8309.41819 BF_2 33.00 0.90 1814 71738525 AAZ40333.1 180 1.6e-10 NFkB [Carcinoscorpius rotundicauda] -- -- -- -- -- K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 157 3.0e-09 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF00554 Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.41821 BF_2 2688.50 13.53 8599 86515360 NP_001034507.1 1560 7.2e-170 dorsal [Tribolium castaneum]>gi|11496169|gb|AAG22858.1| Dorsal [Tribolium castaneum] 462460645 APGK01006274.1 58 2.24642e-18 Dendroctonus ponderosae Seq01006279, whole genome shotgun sequence K09255 K09255 Rel/ankyrin family, other http://www.genome.jp/dbget-bin/www_bget?ko:K09255 P15330 1100 6.4e-118 Embryonic polarity protein dorsal OS=Drosophila melanogaster GN=dl PE=1 SV=2 PF00554//PF01408//PF10415//PF02894//PF08050 Rel homology DNA-binding domain//Oxidoreductase family, NAD-binding Rossmann fold//Fumarase C C-terminus//Oxidoreductase family, C-terminal alpha/beta domain//Tetracycline resistance leader peptide GO:0006099//GO:0006355//GO:0046677//GO:0055114//GO:0008152 tricarboxylic acid cycle//regulation of transcription, DNA-templated//response to antibiotic//oxidation-reduction process//metabolic process GO:0016829//GO:0003700//GO:0003677//GO:0016491 lyase activity//transcription factor activity, sequence-specific DNA binding//DNA binding//oxidoreductase activity GO:0005667 transcription factor complex -- -- Cluster-8309.41823 BF_2 1091.17 40.47 1415 91092922 XP_975933.1 1026 9.8e-109 PREDICTED: uncharacterized protein LOC660277 [Tribolium castaneum]>gi|270003110|gb|EEZ99557.1| hypothetical protein TcasGA2_TC000139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41825 BF_2 249.62 0.97 11087 270014822 EFA11270.1 5203 0.0e+00 hypothetical protein TcasGA2_TC010805 [Tribolium castaneum] 755977937 XM_011310121.1 322 5.07559e-165 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4044 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04689//PF08074//PF03808//PF00640//PF01874//PF00176 DNA binding protein S1FA//CHDCT2 (NUC038) domain//Glycosyl transferase WecB/TagA/CpsF family//Phosphotyrosine interaction domain (PTB/PID)//ATP:dephospho-CoA triphosphoribosyl transferase//SNF2 family N-terminal domain GO:0016310//GO:0006355//GO:0009058 phosphorylation//regulation of transcription, DNA-templated//biosynthetic process GO:0003677//GO:0005524//GO:0046917//GO:0005515//GO:0008270//GO:0016818 DNA binding//ATP binding//triphosphoribosyl-dephospho-CoA synthase activity//protein binding//zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.41827 BF_2 705.00 131.68 511 91091030 XP_975173.1 350 8.6e-31 PREDICTED: retinol dehydrogenase 12-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 259 1.3e-21 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF01073//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0008207//GO:0008209//GO:0055114//GO:0006694 metabolic process//estrogen metabolic process//C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process GO:0003824//GO:0050662//GO:0003854//GO:0016616//GO:0016491 catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.41828 BF_2 4.64 1.12 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41829 BF_2 28.81 0.65 2154 642912575 XP_008200916.1 674 9.8e-68 PREDICTED: guanine nucleotide-releasing factor 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 325 1.2e-28 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF03425 Carbohydrate binding domain (family 11) GO:0005985//GO:0005982//GO:0030245 sucrose metabolic process//starch metabolic process//cellulose catabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.41831 BF_2 173.21 5.78 1540 189236448 XP_973457.2 1720 3.6e-189 PREDICTED: protein tumorous imaginal discs, mitochondrial isoform X2 [Tribolium castaneum]>gi|270005934|gb|EFA02382.1| hypothetical protein TcasGA2_TC008059 [Tribolium castaneum] 642919851 XM_968364.3 179 2.15375e-86 PREDICTED: Tribolium castaneum protein tumorous imaginal discs, mitochondrial (LOC662253), transcript variant X2, mRNA K09504 DNAJA3 DnaJ homolog subfamily A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09504 Q24331 1392 1.6e-152 Protein tumorous imaginal discs, mitochondrial OS=Drosophila virilis GN=l(2)tid PE=2 SV=1 PF00684 DnaJ central domain GO:0006260//GO:0009408//GO:0006457 DNA replication//response to heat//protein folding GO:0046872//GO:0051082//GO:0031072//GO:0005524 metal ion binding//unfolded protein binding//heat shock protein binding//ATP binding GO:0005737 cytoplasm KOG0715 Molecular chaperone (DnaJ superfamily) Cluster-8309.41832 BF_2 104.52 0.99 4724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00219 Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0005520 insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region -- -- Cluster-8309.41833 BF_2 281.36 3.88 3323 642935527 XP_973346.2 1752 1.5e-192 PREDICTED: phosphoacetylglucosamine mutase [Tribolium castaneum] 629692694 XM_007813448.1 35 5.26601e-06 Metarhizium acridum CQMa 102 N-acetylglucosamine-phosphate mutase partial mRNA K01836 E5.4.2.3 phosphoacetylglucosamine mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01836 O95394 1189 1.2e-128 Phosphoacetylglucosamine mutase OS=Homo sapiens GN=PGM3 PE=1 SV=1 PF02880//PF02878//PF00408//PF02879 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I//Phosphoglucomutase/phosphomannomutase, C-terminal domain//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II GO:0005975//GO:0071704 carbohydrate metabolic process//organic substance metabolic process GO:0016868 intramolecular transferase activity, phosphotransferases -- -- KOG2537 Phosphoglucomutase/phosphomannomutase Cluster-8309.41835 BF_2 289.19 0.83 14898 642938921 XP_008195601.1 3295 0.0e+00 PREDICTED: PHD finger protein rhinoceros [Tribolium castaneum] 642938920 XM_008197379.1 365 0 PREDICTED: Tribolium castaneum PHD finger protein rhinoceros (LOC659824), mRNA -- -- -- -- Q7YZH1 1379 5.0e-150 PHD finger protein rhinoceros OS=Drosophila melanogaster GN=rno PE=1 SV=1 PF03708//PF02136//PF02214//PF00651//PF14560//PF00312//PF00130//PF00628 Avian retrovirus envelope protein, gp85//Nuclear transport factor 2 (NTF2) domain//BTB/POZ domain//BTB/POZ domain//Ubiquitin-like domain//Ribosomal protein S15//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger GO:0006810//GO:0006412//GO:0051260//GO:0042254//GO:0035556 transport//translation//protein homooligomerization//ribosome biogenesis//intracellular signal transduction GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0019031//GO:0005622//GO:0005840 viral envelope//intracellular//ribosome KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain Cluster-8309.41836 BF_2 222.61 1.83 5383 91081967 XP_967820.1 2574 1.2e-287 PREDICTED: replication factor C subunit 1 [Tribolium castaneum]>gi|270007366|gb|EFA03814.1| hypothetical protein TcasGA2_TC013927 [Tribolium castaneum] 196009296 XM_002114478.1 41 3.9574e-09 Trichoplax adhaerens hypothetical protein, mRNA K10754 RFC1 replication factor C subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10754 P35600 1845 1.7e-204 Replication factor C subunit 1 OS=Drosophila melanogaster GN=Gnf1 PE=1 SV=2 PF00004//PF03462//PF06144//PF07728//PF05496//PF08519//PF00910//PF00472//PF06414 ATPase family associated with various cellular activities (AAA)//PCRF domain//DNA polymerase III, delta subunit//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Replication factor RFC1 C terminal domain//RNA helicase//RF-1 domain//Zeta toxin GO:0006260//GO:0006415//GO:0006281//GO:0006310//GO:0006449 DNA replication//translational termination//DNA repair//DNA recombination//regulation of translational termination GO:1901363//GO:0016887//GO:0016301//GO:0003689//GO:0003747//GO:0005524//GO:0097159//GO:0003724//GO:0009378//GO:0003677//GO:0003723//GO:0003887//GO:0016149 heterocyclic compound binding//ATPase activity//kinase activity//DNA clamp loader activity//translation release factor activity//ATP binding//organic cyclic compound binding//RNA helicase activity//four-way junction helicase activity//DNA binding//RNA binding//DNA-directed DNA polymerase activity//translation release factor activity, codon specific GO:0005840//GO:0005737//GO:0018444//GO:0009379//GO:0009360//GO:0042575//GO:0005663//GO:0005657 ribosome//cytoplasm//translation release factor complex//Holliday junction helicase complex//DNA polymerase III complex//DNA polymerase complex//DNA replication factor C complex//replication fork KOG1968 Replication factor C, subunit RFC1 (large subunit) Cluster-8309.41837 BF_2 1136.32 13.36 3846 642920880 XP_008192598.1 2499 4.2e-279 PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum]>gi|642920882|ref|XP_008192599.1| PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SP67 1667 5.2e-184 WD repeat-containing protein 26 OS=Danio rerio GN=wdr26 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.41839 BF_2 500.88 22.58 1215 189236533 XP_975493.2 1064 3.3e-113 PREDICTED: triosephosphate isomerase [Tribolium castaneum]>gi|270005300|gb|EFA01748.1| hypothetical protein TcasGA2_TC007346 [Tribolium castaneum] 440200132 JQ784063.1 57 1.11421e-18 Eriocraniella aurosparsella voucher Erau triosephosphate isomerase mRNA, partial cds K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P30741 972 6.3e-104 Triosephosphate isomerase OS=Culex tarsalis GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006013//GO:0006000//GO:0046486//GO:0006094//GO:0015976//GO:0006020//GO:0008152//GO:0006096 mannose metabolic process//fructose metabolic process//glycerolipid metabolic process//gluconeogenesis//carbon utilization//inositol metabolic process//metabolic process//glycolytic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.41840 BF_2 14.45 0.48 1541 642930948 XP_008196153.1 1686 3.1e-185 PREDICTED: protein diaphanous isoform X3 [Tribolium castaneum] -- -- -- -- -- K05745 DIAPH3, DRF3 diaphanous 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05745 P48608 1243 3.0e-135 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF04614 Pex19 protein family -- -- -- -- GO:0005777 peroxisome KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.41842 BF_2 48.19 10.72 475 478258779 ENN78802.1 337 2.6e-29 hypothetical protein YQE_04739, partial [Dendroctonus ponderosae] -- -- -- -- -- K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P82204 288 5.1e-25 Triosephosphate isomerase OS=Bombyx mori GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006094//GO:0015976//GO:0046486//GO:0006000//GO:0006013//GO:0008152//GO:0006096//GO:0006020 gluconeogenesis//carbon utilization//glycerolipid metabolic process//fructose metabolic process//mannose metabolic process//metabolic process//glycolytic process//inositol metabolic process GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.41844 BF_2 22.17 3.04 592 332375176 AEE62729.1 337 3.2e-29 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 P82204 288 6.3e-25 Triosephosphate isomerase OS=Bombyx mori GN=Tpi PE=1 SV=2 PF00121 Triosephosphate isomerase GO:0006020//GO:0006096//GO:0008152//GO:0006000//GO:0046486//GO:0006013//GO:0015976//GO:0006094 inositol metabolic process//glycolytic process//metabolic process//fructose metabolic process//glycerolipid metabolic process//mannose metabolic process//carbon utilization//gluconeogenesis GO:0004807 triose-phosphate isomerase activity -- -- KOG1643 Triosephosphate isomerase Cluster-8309.41847 BF_2 761.25 9.02 3818 642920481 XP_008192369.1 2064 1.1e-228 PREDICTED: liprin-beta-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86W92 885 2.4e-93 Liprin-beta-1 OS=Homo sapiens GN=PPFIBP1 PE=1 SV=2 PF02198//PF07647//PF00536 Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005634 nucleus KOG0249 LAR-interacting protein and related proteins Cluster-8309.41848 BF_2 28.81 0.83 1742 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41851 BF_2 176.00 1.86 4247 642924817 XP_008194053.1 3596 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X5 [Tribolium castaneum] 749755570 XM_011141969.1 132 8.07354e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.3e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.41853 BF_2 70.00 25.89 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41854 BF_2 160.02 5.27 1558 270010741 EFA07189.1 942 5.9e-99 hypothetical protein TcasGA2_TC010195 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 785 3.9e-82 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.41856 BF_2 86.59 2.61 1675 642929822 XP_975593.2 1030 4.0e-109 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.90535e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.4e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.41860 BF_2 36.25 0.51 3289 91091818 XP_966528.1 1765 4.6e-194 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 1147 8.7e-124 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF00060//PF02321//PF10613 Ligand-gated ion channel//Outer membrane efflux protein//Ligated ion channel L-glutamate- and glycine-binding site GO:0006811//GO:0007268//GO:0006810//GO:0007165 ion transport//synaptic transmission//transport//signal transduction GO:0005216//GO:0005215//GO:0004970//GO:0005234 ion channel activity//transporter activity//ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.41861 BF_2 104.48 2.81 1843 91091818 XP_966528.1 1175 6.7e-126 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q38PU3 795 3.2e-83 Glutamate receptor ionotropic, kainate 2 OS=Macaca fascicularis GN=GRIK2 PE=2 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007268//GO:0006811//GO:0007165 synaptic transmission//ion transport//signal transduction GO:0005234//GO:0004970//GO:0005216 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.41863 BF_2 52.29 2.18 1292 91082921 XP_972710.1 699 7.4e-71 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] 462337062 APGK01037684.1 46 1.54628e-12 Dendroctonus ponderosae Seq01037694, whole genome shotgun sequence K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 451 1.7e-43 Annulin OS=Schistocerca americana PE=2 SV=1 PF00868//PF17070 Transglutaminase family//30S ribosomal protein Thx GO:0018149 peptide cross-linking GO:0046872//GO:0003810 metal ion binding//protein-glutamine gamma-glutamyltransferase activity GO:0005840 ribosome -- -- Cluster-8309.41864 BF_2 307.43 2.19 6167 237681143 NP_001153714.1 3148 0.0e+00 poly-(ADP-ribose) polymerase [Tribolium castaneum] 505789579 XM_004605427.1 81 2.63605e-31 PREDICTED: Sorex araneus poly (ADP-ribose) polymerase 1 (PARP1), mRNA K10798 PARP poly http://www.genome.jp/dbget-bin/www_bget?ko:K10798 Q11208 2434 9.5e-273 Poly [ADP-ribose] polymerase OS=Sarcophaga peregrina PE=1 SV=1 PF00644//PF00645//PF02877//PF08063 Poly(ADP-ribose) polymerase catalytic domain//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region//Poly(ADP-ribose) polymerase, regulatory domain//PADR1 (NUC008) domain GO:0006471 protein ADP-ribosylation GO:0008270//GO:0003677//GO:0003950 zinc ion binding//DNA binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1037 NAD+ ADP-ribosyltransferase Parp, required for poly-ADP ribosylation of nuclear proteins Cluster-8309.41865 BF_2 1002.76 13.33 3433 546676660 ERL87624.1 965 2.8e-101 hypothetical protein D910_05015 [Dendroctonus ponderosae] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q9BZC7 416 5.3e-39 ATP-binding cassette sub-family A member 2 OS=Homo sapiens GN=ABCA2 PE=1 SV=3 PF00711//PF00005//PF01225//PF01312 Beta defensin//ABC transporter//Mur ligase family, catalytic domain//FlhB HrpN YscU SpaS Family GO:0006952//GO:0009306//GO:0009058 defense response//protein secretion//biosynthetic process GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0005576//GO:0016020 extracellular region//membrane -- -- Cluster-8309.41867 BF_2 67.21 0.41 7226 642920223 XP_975548.2 2786 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.8e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF10473//PF07926//PF04799//PF02185//PF02183//PF15898//PF17078//PF04111//PF01180//PF00170//PF04508//PF01920//PF06005 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//fzo-like conserved region//Hr1 repeat//Homeobox associated leucine zipper//cGMP-dependent protein kinase interacting domain//SWI5-dependent HO expression protein 3//Autophagy protein Apg6//Dihydroorotate dehydrogenase//bZIP transcription factor//Viral A-type inclusion protein repeat//Prefoldin subunit//Protein of unknown function (DUF904) GO:0055114//GO:0006606//GO:0006355//GO:0006914//GO:0007165//GO:0000917//GO:0043093//GO:0008053//GO:0048309//GO:0051028//GO:0006457//GO:0016032 oxidation-reduction process//protein import into nucleus//regulation of transcription, DNA-templated//autophagy//signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis//mitochondrial fusion//endoplasmic reticulum inheritance//mRNA transport//protein folding//viral process GO:0016627//GO:0003700//GO:0019901//GO:0043565//GO:0051082//GO:0008134//GO:0003924//GO:0045502//GO:0042803 oxidoreductase activity, acting on the CH-CH group of donors//transcription factor activity, sequence-specific DNA binding//protein kinase binding//sequence-specific DNA binding//unfolded protein binding//transcription factor binding//GTPase activity//dynein binding//protein homodimerization activity GO:0005737//GO:0016272//GO:0016021//GO:0005741//GO:0005667//GO:0030286 cytoplasm//prefoldin complex//integral component of membrane//mitochondrial outer membrane//transcription factor complex//dynein complex -- -- Cluster-8309.41868 BF_2 109.76 1.26 3922 642928023 XP_008200123.1 1920 5.9e-212 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X1 [Tribolium castaneum]>gi|270010887|gb|EFA07335.1| hypothetical protein TcasGA2_TC015931 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.67844e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q9UBC2 1002 6.8e-107 Epidermal growth factor receptor substrate 15-like 1 OS=Homo sapiens GN=EPS15L1 PE=1 SV=1 PF03836//PF03938//PF16326//PF07851//PF05531//PF01920//PF10174//PF00036//PF13202//PF13833//PF13405//PF13499//PF04111//PF06005//PF10186//PF12763//PF16716 RasGAP C-terminus//Outer membrane protein (OmpH-like)//ABC transporter C-terminal domain//TMPIT-like protein//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//RIM-binding protein of the cytomatrix active zone//EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Autophagy protein Apg6//Protein of unknown function (DUF904)//Vacuolar sorting 38 and autophagy-related subunit 14//Cytoskeletal-regulatory complex EF hand//Bone marrow stromal antigen 2 GO:0007264//GO:0000917//GO:0043093//GO:0006457//GO:0051607//GO:0010508//GO:0006914 small GTPase mediated signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis//protein folding//defense response to virus//positive regulation of autophagy//autophagy GO:0005509//GO:0003677//GO:0005515//GO:0051082//GO:0005096 calcium ion binding//DNA binding//protein binding//unfolded protein binding//GTPase activator activity GO:0048786//GO:0005737//GO:0016272//GO:0019028//GO:0016021 presynaptic active zone//cytoplasm//prefoldin complex//viral capsid//integral component of membrane KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.41869 BF_2 10.33 0.37 1460 642920217 XP_008192253.1 612 1.0e-60 PREDICTED: zinc finger CCCH domain-containing protein 11A-like isoform X1 [Tribolium castaneum] 642920218 XM_008194032.1 148 3.48561e-69 PREDICTED: Tribolium castaneum zinc finger CCCH domain-containing protein 11A-like (LOC103312695), transcript variant X2, mRNA -- -- -- -- Q6NZF1 328 3.6e-29 Zinc finger CCCH domain-containing protein 11A OS=Mus musculus GN=Zc3h11a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41870 BF_2 162.49 0.99 7119 642920223 XP_975548.2 2830 0.0e+00 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P5D4 604 1.7e-60 Centrosomal protein of 135 kDa OS=Mus musculus GN=Cep135 PE=1 SV=1 PF01180//PF00170//PF02183 Dihydroorotate dehydrogenase//bZIP transcription factor//Homeobox associated leucine zipper GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0003700//GO:0016627//GO:0043565 transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//sequence-specific DNA binding GO:0005737//GO:0005667 cytoplasm//transcription factor complex -- -- Cluster-8309.41871 BF_2 63.49 0.39 7170 642920223 XP_975548.2 2514 1.4e-280 PREDICTED: centrosomal protein of 135 kDa [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66GS9 516 2.8e-50 Centrosomal protein of 135 kDa OS=Homo sapiens GN=CEP135 PE=1 SV=2 PF17078//PF06005//PF02183//PF00170//PF01180//PF10473//PF01166 SWI5-dependent HO expression protein 3//Protein of unknown function (DUF904)//Homeobox associated leucine zipper//bZIP transcription factor//Dihydroorotate dehydrogenase//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family GO:0000917//GO:0043093//GO:0055114//GO:0006355//GO:0048309//GO:0051028 barrier septum assembly//FtsZ-dependent cytokinesis//oxidation-reduction process//regulation of transcription, DNA-templated//endoplasmic reticulum inheritance//mRNA transport GO:0003700//GO:0016627//GO:0043565//GO:0042803//GO:0008134//GO:0045502 transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//sequence-specific DNA binding//protein homodimerization activity//transcription factor binding//dynein binding GO:0005737//GO:0005667//GO:0030286 cytoplasm//transcription factor complex//dynein complex -- -- Cluster-8309.41872 BF_2 446.67 21.07 1174 642920217 XP_008192253.1 612 8.3e-61 PREDICTED: zinc finger CCCH domain-containing protein 11A-like isoform X1 [Tribolium castaneum] 642920218 XM_008194032.1 149 7.74624e-70 PREDICTED: Tribolium castaneum zinc finger CCCH domain-containing protein 11A-like (LOC103312695), transcript variant X2, mRNA -- -- -- -- Q6NZF1 328 2.9e-29 Zinc finger CCCH domain-containing protein 11A OS=Mus musculus GN=Zc3h11a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41874 BF_2 148.45 1.61 4135 642923667 XP_008193834.1 3308 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] 170052083 XM_001862026.1 43 2.34522e-10 Culex quinquefasciatus multidrug resistance-associated protein 14, mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2199 1.1e-245 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664//PF13304//PF01926//PF00005//PF01416//PF03193 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//tRNA pseudouridine synthase//Protein of unknown function, DUF258 GO:0055085//GO:0006810//GO:0009451//GO:0001522 transmembrane transport//transport//RNA modification//pseudouridine synthesis GO:0005524//GO:0003723//GO:0003924//GO:0005525//GO:0009982//GO:0016887//GO:0042626 ATP binding//RNA binding//GTPase activity//GTP binding//pseudouridine synthase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.41876 BF_2 845.95 8.14 4637 642920570 XP_008192465.1 1475 2.8e-160 PREDICTED: synaptotagmin 1 isoform X1 [Tribolium castaneum] 642920569 XM_008194243.1 440 0 PREDICTED: Tribolium castaneum synaptotagmin 1 (Syt1), transcript variant X1, mRNA K15290 SYT1 synaptotagmin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15290 P21521 1327 1.7e-144 Synaptotagmin 1 OS=Drosophila melanogaster GN=Syt1 PE=1 SV=3 PF03821//PF00168//PF05478 Golgi 4-transmembrane spanning transporter//C2 domain//Prominin -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41877 BF_2 1871.95 48.92 1888 549438543 AGX25160.1 1186 3.7e-127 cathepsin B precursor [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P90850 674 3.5e-69 Uncharacterized peptidase C1-like protein F26E4.3 OS=Caenorhabditis elegans GN=F26E4.3 PE=1 SV=3 PF04218//PF01033//PF00112//PF03051 CENP-B N-terminal DNA-binding domain//Somatomedin B domain//Papain family cysteine protease//Peptidase C1-like family GO:0007165//GO:0006955//GO:0006508 signal transduction//immune response//proteolysis GO:0005044//GO:0003677//GO:0004197//GO:0030247//GO:0008234 scavenger receptor activity//DNA binding//cysteine-type endopeptidase activity//polysaccharide binding//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.41879 BF_2 337.36 3.65 4154 642926804 XP_008195020.1 1279 1.3e-137 PREDICTED: vacuole membrane protein 1 isoform X2 [Tribolium castaneum] 241594857 XM_002404356.1 107 6.23431e-46 Ixodes scapularis vacuole membrane protein, putative, mRNA -- -- -- -- Q6INE8 937 2.5e-99 Vacuole membrane protein 1 OS=Xenopus laevis GN=vmp1 PE=2 SV=1 PF00323 Mammalian defensin GO:0006952 defense response -- -- GO:0005576 extracellular region KOG1109 Vacuole membrane protein VMP1 Cluster-8309.41882 BF_2 924.44 12.00 3509 642937569 XP_008199101.1 2344 3.6e-261 PREDICTED: amidophosphoribosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1926 4.4e-214 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF05195//PF00156 Aminopeptidase P, N-terminal domain//Phosphoribosyl transferase domain GO:0009116 nucleoside metabolic process GO:0004177//GO:0030145 aminopeptidase activity//manganese ion binding -- -- KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.41884 BF_2 252.35 5.46 2221 380017601 XP_003692741.1 1811 1.4e-199 PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X2 [Apis florea] -- -- -- -- -- -- -- -- -- Q6GN91 1105 4.4e-119 5'-nucleotidase domain-containing protein 3 OS=Xenopus laevis GN=nt5dc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.41885 BF_2 232.34 1.14 8841 642918564 XP_008199298.1 1086 6.8e-115 PREDICTED: large proline-rich protein BAG6 isoform X2 [Tribolium castaneum] 242016373 XM_002428751.1 60 1.78567e-19 Pediculus humanus corporis RWD domain-containing protein, putative, mRNA -- -- -- -- A4IH17 240 3.5e-18 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF05773//PF00240//PF01153//PF14560//PF07469 RWD domain//Ubiquitin family//Glypican//Ubiquitin-like domain//Domain of unknown function (DUF1518) -- -- GO:0005515//GO:0043395 protein binding//heparan sulfate proteoglycan binding GO:0016020//GO:0005578//GO:0005634 membrane//proteinaceous extracellular matrix//nucleus KOG4018 Uncharacterized conserved protein, contains RWD domain Cluster-8309.41887 BF_2 838.97 9.72 3897 642918562 XP_008199292.1 1559 4.2e-170 PREDICTED: large proline-rich protein BAG6 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH17 362 1.1e-32 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF07469 Domain of unknown function (DUF1518) -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.41888 BF_2 33.19 1.30 1355 91092022 XP_970951.1 336 9.6e-29 PREDICTED: cathepsin L1 [Tribolium castaneum]>gi|270001246|gb|EEZ97693.1| cathepsin L precursor [Tribolium castaneum] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 P15242 293 3.8e-25 Testin-2 OS=Rattus norvegicus GN=Testin PE=1 SV=2 PF00112 Papain family cysteine protease GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.41892 BF_2 147.54 7.70 1089 642928725 XP_973998.2 1012 3.2e-107 PREDICTED: probable dolichol-phosphate mannosyltransferase [Tribolium castaneum] -- -- -- -- -- K00721 DPM1 dolichol-phosphate mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00721 O60762 954 6.9e-102 Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens GN=DPM1 PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2978 Dolichol-phosphate mannosyltransferase Cluster-8309.41893 BF_2 317.46 15.34 1153 642928725 XP_973998.2 1039 2.5e-110 PREDICTED: probable dolichol-phosphate mannosyltransferase [Tribolium castaneum] -- -- -- -- -- K00721 DPM1 dolichol-phosphate mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00721 O60762 981 5.4e-105 Dolichol-phosphate mannosyltransferase subunit 1 OS=Homo sapiens GN=DPM1 PE=1 SV=1 PF13506 Glycosyl transferase family 21 -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG2978 Dolichol-phosphate mannosyltransferase Cluster-8309.41894 BF_2 308.34 2.42 5612 189241221 XP_001812199.1 676 1.5e-67 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 510 1.1e-49 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF01166//PF04952//PF07544//PF00246//PF06008//PF04977//PF16326//PF05531//PF05405 TSC-22/dip/bun family//Succinylglutamate desuccinylase / Aspartoacylase family//RNA polymerase II transcription mediator complex subunit 9//Zinc carboxypeptidase//Laminin Domain I//Septum formation initiator//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0008152//GO:0015986//GO:0006508//GO:0030155//GO:0030334//GO:0007165//GO:0045995//GO:0015992//GO:0007049//GO:0006357//GO:0006355 metabolic process//ATP synthesis coupled proton transport//proteolysis//regulation of cell adhesion//regulation of cell migration//signal transduction//regulation of embryonic development//proton transport//cell cycle//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0001104//GO:0003677//GO:0016788//GO:0003700//GO:0004181//GO:0015078//GO:0005102//GO:0008270 RNA polymerase II transcription cofactor activity//DNA binding//hydrolase activity, acting on ester bonds//transcription factor activity, sequence-specific DNA binding//metallocarboxypeptidase activity//hydrogen ion transmembrane transporter activity//receptor binding//zinc ion binding GO:0005667//GO:0016592//GO:0019028 transcription factor complex//mediator complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.41896 BF_2 357.00 8.31 2085 478252467 ENN72889.1 852 2.2e-88 hypothetical protein YQE_10459, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF00822//PF13903 Clc-like//PMP-22/EMP/MP20/Claudin family//PMP-22/EMP/MP20/Claudin tight junction -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.41899 BF_2 1143.74 6.82 7303 642911903 XP_008199015.1 1233 5.0e-132 PREDICTED: heat shock factor protein-like isoform X3 [Tribolium castaneum] 642911902 XM_008200793.1 159 1.36339e-74 PREDICTED: Tribolium castaneum heat shock factor protein-like (LOC103314511), transcript variant X4, mRNA K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P22813 658 9.8e-67 Heat shock factor protein OS=Drosophila melanogaster GN=Hsf PE=1 SV=1 PF00637//PF00447 Region in Clathrin and VPS//HSF-type DNA-binding GO:0006886//GO:0016192//GO:0006355 intracellular protein transport//vesicle-mediated transport//regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0627 Heat shock transcription factor Cluster-8309.419 BF_2 23.89 1.64 896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41901 BF_2 27.35 0.83 1669 642926100 XP_008194784.1 875 3.7e-91 PREDICTED: polycomb complex protein BMI-1-A [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 Q91648 604 4.1e-61 Polycomb complex protein BMI-1-A OS=Xenopus laevis GN=bmi1a PE=1 SV=1 PF13639//PF03315//PF03854//PF01213//PF10099//PF03341//PF11789//PF00097//PF12678//PF14634 Ring finger domain//Serine dehydratase beta chain//P-11 zinc finger//Adenylate cyclase associated (CAP) N terminal//Anti-sigma-K factor rskA//Poxvirus mRNA capping enzyme, small subunit//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0006544//GO:0006370//GO:0009451//GO:0006534//GO:0007010//GO:0006563//GO:0006094//GO:0006566 glycine metabolic process//7-methylguanosine mRNA capping//RNA modification//cysteine metabolic process//cytoskeleton organization//L-serine metabolic process//gluconeogenesis//threonine metabolic process GO:0005515//GO:0003723//GO:0004482//GO:0046872//GO:0003779//GO:0051539//GO:0003941//GO:0008270 protein binding//RNA binding//mRNA (guanine-N7-)-methyltransferase activity//metal ion binding//actin binding//4 iron, 4 sulfur cluster binding//L-serine ammonia-lyase activity//zinc ion binding GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG2660 Locus-specific chromosome binding proteins Cluster-8309.41902 BF_2 51.03 5.21 697 676490959 XP_009065437.1 141 2.0e-06 hypothetical protein LOTGIDRAFT_132613, partial [Lottia gigantea]>gi|556095205|gb|ESO83858.1| hypothetical protein LOTGIDRAFT_132613, partial [Lottia gigantea] 9809 X13039.1 71 1.03319e-26 Philosamia cynthia ricini 5S rRNA -- -- -- -- -- -- -- -- PF01213 Adenylate cyclase associated (CAP) N terminal GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.41903 BF_2 113.00 19.22 533 642938085 XP_008190376.1 401 1.1e-36 PREDICTED: histone H1-III-like [Tribolium castaneum] -- -- -- -- -- K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P40265 304 8.0e-27 Histone H1-III OS=Glyptotendipes barbipes PE=3 SV=1 PF00538//PF06333 linker histone H1 and H5 family//Mediator complex subunit 13 C-terminal GO:0006357//GO:0006334 regulation of transcription from RNA polymerase II promoter//nucleosome assembly GO:0003677//GO:0001104 DNA binding//RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592//GO:0000786 nucleus//mediator complex//nucleosome -- -- Cluster-8309.41904 BF_2 424.37 2.30 8002 642937407 XP_008198823.1 2893 0.0e+00 PREDICTED: dynamin isoform X2 [Tribolium castaneum] 665799739 XM_008549577.1 312 1.32519e-159 PREDICTED: Microplitis demolitor dynamin-like (LOC103571419), mRNA K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 2535 2.4e-284 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF01926//PF01031//PF08023//PF02212 50S ribosome-binding GTPase//Dynamin central region//Frog antimicrobial peptide//Dynamin GTPase effector domain GO:0006952 defense response GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0005576 extracellular region KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.41907 BF_2 191.68 5.76 1680 642916441 XP_008191028.1 1494 6.3e-163 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X2 [Tribolium castaneum] 572301862 XM_006616904.1 66 1.54234e-23 PREDICTED: Apis dorsata transmembrane and coiled-coil domains protein 2-like (LOC102681558), transcript variant X6, mRNA -- -- -- -- Q80W04 671 7.0e-69 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF08702//PF04513//PF02601//PF02184//PF05073//PF03462//PF05478//PF05929//PF12919//PF05531//PF07851 Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Exonuclease VII, large subunit//HAT (Half-A-TPR) repeat//Baculovirus P24 capsid protein//PCRF domain//Prominin//Phage capsid scaffolding protein (GPO) serine peptidase//TcdA/TcdB catalytic glycosyltransferase domain//Nucleopolyhedrovirus P10 protein//TMPIT-like protein GO:0006449//GO:0030168//GO:0006308//GO:0019069//GO:0007165//GO:0051258//GO:0006415//GO:0006396 regulation of translational termination//platelet activation//DNA catabolic process//viral capsid assembly//signal transduction//protein polymerization//translational termination//RNA processing GO:0008855//GO:0016149//GO:0030674//GO:0016757//GO:0005198//GO:0005102 exodeoxyribonuclease VII activity//translation release factor activity, codon specific//protein binding, bridging//transferase activity, transferring glycosyl groups//structural molecule activity//receptor binding GO:0019031//GO:0016021//GO:0019028//GO:0009318//GO:0005840//GO:0005622//GO:0018444//GO:0005577//GO:0005737 viral envelope//integral component of membrane//viral capsid//exodeoxyribonuclease VII complex//ribosome//intracellular//translation release factor complex//fibrinogen complex//cytoplasm KOG3850 Predicted membrane protein Cluster-8309.41908 BF_2 266.54 0.44 25453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03493//PF01184 Calcium-activated BK potassium channel alpha subunit//GPR1/FUN34/yaaH family GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.41910 BF_2 355.34 1.68 9120 642938745 XP_008199871.1 2455 1.3e-273 PREDICTED: cytosolic purine 5'-nucleotidase isoform X1 [Tribolium castaneum] 41393060 NM_201427.1 43 5.19516e-10 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1766 4.1e-195 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.41911 BF_2 1064.26 8.95 5262 642914743 XP_008190334.1 2249 5.6e-250 PREDICTED: uncharacterized protein LOC655834 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H4G4 301 1.8e-25 Golgi-associated plant pathogenesis-related protein 1 OS=Homo sapiens GN=GLIPR2 PE=1 SV=3 PF02038 ATP1G1/PLM/MAT8 family GO:0006811 ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.41912 BF_2 28.04 0.66 2052 642936475 XP_008198451.1 1608 4.6e-176 PREDICTED: LOW QUALITY PROTEIN: G protein-coupled receptor kinase 2 [Tribolium castaneum] 642936474 XM_008200229.1 480 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 2 (LOC656376), mRNA K08291 GRK4_5_6 G protein-coupled receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08291 P43249 1045 3.7e-112 G protein-coupled receptor kinase 5 OS=Bos taurus GN=GRK5 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0986 G protein-coupled receptor kinase Cluster-8309.41913 BF_2 1941.81 14.05 6069 546670634 ERL83320.1 5425 0.0e+00 hypothetical protein D910_00214, partial [Dendroctonus ponderosae] 170050062 XM_001870954.1 71 9.39562e-26 Culex quinquefasciatus ubiquitin specific protease, mRNA K11837 USP6_32 ubiquitin carboxyl-terminal hydrolase 6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K11837 Q8NFA0 1141 8.0e-123 Ubiquitin carboxyl-terminal hydrolase 32 OS=Homo sapiens GN=USP32 PE=1 SV=1 PF13499//PF00036//PF05191//PF13405//PF06337//PF11421//PF00443 EF-hand domain pair//EF hand//Adenylate kinase, active site lid//EF-hand domain//DUSP domain//ATP synthase F1 beta subunit//Ubiquitin carboxyl-terminal hydrolase GO:0006144//GO:0046034//GO:0006508//GO:0016579//GO:0006754 purine nucleobase metabolic process//ATP metabolic process//proteolysis//protein deubiquitination//ATP biosynthetic process GO:0004843//GO:0005524//GO:0036459//GO:0016887//GO:0005509//GO:0004017 ubiquitin-specific protease activity//ATP binding//ubiquitinyl hydrolase activity//ATPase activity//calcium ion binding//adenylate kinase activity GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.41915 BF_2 7467.00 303.31 1317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41917 BF_2 323.98 5.89 2587 642920758 XP_971086.2 1029 8.1e-109 PREDICTED: protein-L-isoaspartate(D-aspartate) O-methyltransferase [Tribolium castaneum] 242014347 XM_002427808.1 67 6.65268e-24 Pediculus humanus corporis protein-L-isoaspartate O-methyltransferase, putative, mRNA K00573 E2.1.1.77, pcm protein-L-isoaspartate(D-aspartate) O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00573 Q5F3N1 775 9.4e-81 Protein-L-isoaspartate(D-aspartate) O-methyltransferase OS=Gallus gallus GN=PCMT1 PE=2 SV=3 PF01209//PF01596//PF08241//PF05175//PF01135 ubiE/COQ5 methyltransferase family//O-methyltransferase//Methyltransferase domain//Methyltransferase small domain//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0008152//GO:0006464//GO:0006479//GO:0046500 metabolic process//cellular protein modification process//protein methylation//S-adenosylmethionine metabolic process GO:0008168//GO:0004719//GO:0008171 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//O-methyltransferase activity -- -- KOG1661 Protein-L-isoaspartate(D-aspartate) O-methyltransferase Cluster-8309.41921 BF_2 25.15 0.33 3454 642913398 XP_008200993.1 1367 6.9e-148 PREDICTED: fruitless isoform X3 [Tribolium castaneum] 642913407 XM_008202776.1 210 2.86082e-103 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X7, mRNA -- -- -- -- Q8IN81 552 9.1e-55 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00096//PF00651 Zinc finger, C2H2 type//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.41922 BF_2 94.89 0.86 4925 189238112 XP_001814047.1 481 5.4e-45 PREDICTED: bleomycin hydrolase [Tribolium castaneum]>gi|270008738|gb|EFA05186.1| hypothetical protein TcasGA2_TC015316 [Tribolium castaneum] 767931498 XM_005262871.3 83 1.62498e-32 PREDICTED: Homo sapiens KIAA0922 (KIAA0922), transcript variant X5, mRNA K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 Q8R016 366 4.8e-33 Bleomycin hydrolase OS=Mus musculus GN=Blmh PE=1 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG4128 Bleomycin hydrolases and aminopeptidases of cysteine protease family Cluster-8309.41923 BF_2 1005.06 5.83 7504 642912357 XP_008199608.1 1411 1.2e-152 PREDICTED: PHD and RING finger domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17586 PHRF1 PHD and RING finger domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17586 Q63625 468 1.1e-44 PHD and RING finger domain-containing protein 1 OS=Rattus norvegicus GN=Phrf1 PE=1 SV=2 PF13639//PF03854//PF13994//PF12861//PF00130//PF00097//PF17123//PF12678//PF00628//PF14634 Ring finger domain//P-11 zinc finger//PgaD-like protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain GO:0035556//GO:0042710//GO:0016567 intracellular signal transduction//biofilm formation//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding//RNA binding GO:0005680 anaphase-promoting complex KOG0825 PHD Zn-finger protein Cluster-8309.41924 BF_2 894.94 5.06 7688 189241221 XP_001812199.1 1084 1.0e-114 PREDICTED: carboxypeptidase D-like [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 746 6.4e-77 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF00246//PF00018//PF06008//PF05531//PF01166//PF04952//PF07544 Zinc carboxypeptidase//SH3 domain//Laminin Domain I//Nucleopolyhedrovirus P10 protein//TSC-22/dip/bun family//Succinylglutamate desuccinylase / Aspartoacylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0008152//GO:0006508//GO:0030155//GO:0007165//GO:0030334//GO:0045995//GO:0006357//GO:0006355 metabolic process//proteolysis//regulation of cell adhesion//signal transduction//regulation of cell migration//regulation of embryonic development//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0005515//GO:0001104//GO:0016788//GO:0004181//GO:0003700//GO:0005102//GO:0008270 protein binding//RNA polymerase II transcription cofactor activity//hydrolase activity, acting on ester bonds//metallocarboxypeptidase activity//transcription factor activity, sequence-specific DNA binding//receptor binding//zinc ion binding GO:0005667//GO:0016592//GO:0019028 transcription factor complex//mediator complex//viral capsid KOG2649 Zinc carboxypeptidase Cluster-8309.41929 BF_2 265.29 1.67 6939 642913880 XP_008201199.1 5718 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X2 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.35125e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q8TDW5 642 6.7e-65 Synaptotagmin-like protein 5 OS=Homo sapiens GN=SYTL5 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.41931 BF_2 15.86 0.31 2395 91079744 XP_970506.1 923 1.5e-96 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 768418016 XM_011551374.1 201 1.98993e-98 PREDICTED: Plutella xylostella probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial (LOC105381602), transcript variant X5, mRNA K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 905 7.3e-96 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF02770//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0008152//GO:0006118//GO:0055114 metabolic process//obsolete electron transport//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.41933 BF_2 557.03 12.71 2121 195356716 XP_002044796.1 166 7.8e-09 GM13286 [Drosophila sechellia]>gi|194121629|gb|EDW43672.1| GM13286 [Drosophila sechellia] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41934 BF_2 322.00 9.08 1771 642919169 XP_008191766.1 1427 3.9e-155 PREDICTED: zinc finger FYVE domain-containing protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17603 ZFYVE1 zinc finger FYVE domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17603 Q810J8 982 6.4e-105 Zinc finger FYVE domain-containing protein 1 OS=Mus musculus GN=Zfyve1 PE=2 SV=2 PF02263//PF04548//PF01926 Guanylate-binding protein, N-terminal domain//AIG1 family//50S ribosome-binding GTPase -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- -- -- Cluster-8309.41935 BF_2 74.99 1.33 2641 642938917 XP_001808877.2 932 1.5e-97 PREDICTED: suppressor protein SRP40-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03884 Domain of unknown function (DUF329) -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.41936 BF_2 1535.82 37.25 2012 642914207 XP_008201590.1 805 5.9e-83 PREDICTED: uncharacterized protein LOC661830 isoform X5 [Tribolium castaneum] 827545791 XM_004925600.2 39 1.89338e-08 PREDICTED: Bombyx mori uncharacterized LOC101735549 (LOC101735549), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.41940 BF_2 511.99 4.81 4742 642927612 XP_973436.3 1023 7.3e-108 PREDICTED: cell growth regulator with RING finger domain protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24799 317 2.2e-27 Myophilin OS=Echinococcus granulosus PE=2 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.41943 BF_2 493.33 21.43 1250 675389799 KFM82696.1 885 1.9e-92 Myosin light chain kinase, smooth muscle, partial [Stegodyphus mimosarum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q15746 729 9.8e-76 Myosin light chain kinase, smooth muscle OS=Homo sapiens GN=MYLK PE=1 SV=4 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.41945 BF_2 743.96 8.36 4008 91090288 XP_971422.1 2498 5.7e-279 PREDICTED: pre-rRNA processing protein FTSJ3 [Tribolium castaneum]>gi|270013436|gb|EFA09884.1| hypothetical protein TcasGA2_TC012032 [Tribolium castaneum] 751213900 XM_011161477.1 235 4.21021e-117 PREDICTED: Solenopsis invicta pre-rRNA processing protein FTSJ3 (LOC105195860), mRNA K14857 SPB1, FTSJ3 AdoMet-dependent rRNA methyltransferase SPB1 http://www.genome.jp/dbget-bin/www_bget?ko:K14857 Q5ZKM1 1045 7.2e-112 pre-rRNA processing protein FTSJ3 OS=Gallus gallus GN=FTSJ3 PE=2 SV=2 PF01728//PF07780//PF00844 FtsJ-like methyltransferase//Spb1 C-terminal domain//Geminivirus coat protein/nuclear export factor BR1 family GO:0006364//GO:0008152//GO:0032259 rRNA processing//metabolic process//methylation GO:0008168//GO:0005198 methyltransferase activity//structural molecule activity GO:0019028//GO:0005634 viral capsid//nucleus KOG1098 Putative SAM-dependent rRNA methyltransferase SPB1 Cluster-8309.41947 BF_2 7.25 0.36 1127 642936612 XP_008198506.1 481 1.2e-45 PREDICTED: uncharacterized protein LOC661523 isoform X2 [Tribolium castaneum]>gi|270013067|gb|EFA09515.1| hypothetical protein TcasGA2_TC011617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41950 BF_2 336.00 2.61 5665 642937243 XP_008198753.1 2474 4.9e-276 PREDICTED: aryl hydrocarbon receptor [Tribolium castaneum] 197108533 EU912437.1 523 0 Tribolium castaneum spineless mRNA, partial cds -- -- -- -- Q8R4S4 951 8.0e-101 Aryl hydrocarbon receptor OS=Mus spicilegus GN=Ahr PE=2 SV=1 PF04062//PF08447//PF00010//PF00989 ARP2/3 complex ARPC3 (21 kDa) subunit//PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0030833//GO:0034314//GO:0006355 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation//regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity GO:0005856//GO:0005885 cytoskeleton//Arp2/3 protein complex KOG3560 Aryl-hydrocarbon receptor Cluster-8309.41951 BF_2 97.05 2.25 2088 768443595 XP_011563618.1 837 1.2e-86 PREDICTED: uncharacterized protein LOC105393537 [Plutella xylostella] -- -- -- -- -- -- -- -- -- P03352 132 2.8e-06 Gag polyprotein OS=Maedi visna virus (strain 1514) GN=gag PE=3 SV=1 PF00098//PF09668 Zinc knuckle//Aspartyl protease GO:0006508 proteolysis GO:0008270//GO:0003676//GO:0004190 zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.41952 BF_2 1363.07 44.69 1563 478256432 ENN76619.1 1029 4.9e-109 hypothetical protein YQE_06876, partial [Dendroctonus ponderosae] 766918334 XM_011499440.1 192 1.29755e-93 PREDICTED: Ceratosolen solmsi marchali protein enhancer of sevenless 2B (LOC105362095), mRNA K04364 GRB2 growth factor receptor-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04364 Q08012 948 4.9e-101 Protein enhancer of sevenless 2B OS=Drosophila melanogaster GN=drk PE=1 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG3601 Adaptor protein GRB2, contains SH2 and SH3 domains Cluster-8309.41953 BF_2 125.74 1.98 2946 332374296 AEE62289.1 1127 4.0e-120 unknown [Dendroctonus ponderosae] -- -- -- -- -- K15100 SLC25A1, CTP solute carrier family 25 (mitochondrial citrate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15100 P34519 928 1.9e-98 Putative tricarboxylate transport protein, mitochondrial OS=Caenorhabditis elegans GN=K11H3.3 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0756 Mitochondrial tricarboxylate/dicarboxylate carrier proteins Cluster-8309.41954 BF_2 677.71 5.31 5626 91092690 XP_971771.1 1827 5.1e-201 PREDICTED: myocyte-specific enhancer factor 2 isoform X2 [Tribolium castaneum] 795078923 XM_012021543.1 181 6.18217e-87 PREDICTED: Vollenhovia emeryi myocyte-specific enhancer factor 2 (LOC105567029), transcript variant X4, mRNA K04454 MEF2C MADS-box transcription enhancer factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K04454 P40791 941 1.2e-99 Myocyte-specific enhancer factor 2 OS=Drosophila melanogaster GN=Mef2 PE=1 SV=3 PF00319//PF03554 SRF-type transcription factor (DNA-binding and dimerisation domain)//UL73 viral envelope glycoprotein -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0019031 viral envelope KOG0014 MADS box transcription factor Cluster-8309.41955 BF_2 1587.73 19.55 3685 270014029 EFA10477.1 699 2.1e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.23012e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- O94842 173 8.6e-11 TOX high mobility group box family member 4 OS=Homo sapiens GN=TOX4 PE=1 SV=1 PF11770//PF03460 GRB2-binding adapter (GAPT)//Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.41956 BF_2 515.68 5.93 3928 642936984 XP_008198642.1 2321 1.9e-258 PREDICTED: bromodomain-containing protein 3-like isoform X5 [Tribolium castaneum] 751803975 XM_011213848.1 114 7.56827e-50 PREDICTED: Bactrocera dorsalis homeotic protein female sterile-like (LOC105232218), mRNA K11721 BRD3 bromodomain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11721 Q15059 993 7.5e-106 Bromodomain-containing protein 3 OS=Homo sapiens GN=BRD3 PE=1 SV=1 PF13965//PF00439//PF08290//PF12761//PF01025//PF02325//PF03938 dsRNA-gated channel SID-1//Bromodomain//Hepatitis core protein, putative zinc finger//Actin cytoskeleton-regulatory complex protein END3//GrpE//YGGT family//Outer membrane protein (OmpH-like) GO:0006897//GO:0007015//GO:0006457//GO:0009405//GO:0015931//GO:0033227 endocytosis//actin filament organization//protein folding//pathogenesis//nucleobase-containing compound transport//dsRNA transport GO:0005515//GO:0005198//GO:0051033//GO:0000774//GO:0051087//GO:0042803//GO:0051082 protein binding//structural molecule activity//RNA transmembrane transporter activity//adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity//unfolded protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1474 Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins Cluster-8309.41957 BF_2 44.01 0.39 5013 642936988 XP_008198644.1 722 6.2e-73 PREDICTED: bromodomain-containing protein 3-like isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13709 137 1.7e-06 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 PF01397//PF04055 Terpene synthase, N-terminal domain//Radical SAM superfamily GO:0008152 metabolic process GO:0003824//GO:0051536//GO:0016829//GO:0010333 catalytic activity//iron-sulfur cluster binding//lyase activity//terpene synthase activity -- -- -- -- Cluster-8309.41961 BF_2 7.00 4.91 341 270004866 EFA01314.1 286 1.5e-23 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 215 1.1e-16 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.41962 BF_2 165.52 4.51 1822 642915333 XP_008190576.1 659 4.5e-66 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 484 3.7e-47 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF00034 Cytochrome c GO:0006118 obsolete electron transport GO:0009055//GO:0020037 electron carrier activity//heme binding -- -- -- -- Cluster-8309.41966 BF_2 52.65 0.68 3524 332372718 AEE61501.1 1823 9.4e-201 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 761 5.4e-79 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.41969 BF_2 49.87 0.68 3346 478255222 ENN75451.1 251 1.7e-18 hypothetical protein YQE_08001, partial [Dendroctonus ponderosae] 642940046 XM_008194216.1 41 2.44979e-09 PREDICTED: Tribolium castaneum uncharacterized LOC103312751 (LOC103312751), mRNA K11984 SART1, HAF, SNU66 U4/U6.U5 tri-snRNP-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11984 -- -- -- -- PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.41970 BF_2 10.46 0.95 749 642934860 XP_971174.2 507 7.9e-49 PREDICTED: NADPH--cytochrome P450 reductase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00327 POR NADPH-ferrihemoprotein reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00327 Q27597 447 2.9e-43 NADPH--cytochrome P450 reductase OS=Drosophila melanogaster GN=Cpr PE=2 SV=2 PF00667//PF00258 FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0010181//GO:0016491 FMN binding//oxidoreductase activity -- -- KOG1158 NADP/FAD dependent oxidoreductase Cluster-8309.41971 BF_2 654.41 40.75 959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03525 Meiotic recombination protein rec114 GO:0007131 reciprocal meiotic recombination -- -- -- -- -- -- Cluster-8309.41973 BF_2 6.03 0.39 937 665786917 XP_008554781.1 386 1.1e-34 PREDICTED: [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Microplitis demolitor] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 375 8.2e-35 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0787 Dehydrogenase kinase Cluster-8309.41974 BF_2 150.58 8.37 1040 91092090 XP_971602.1 380 5.8e-34 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 -- -- -- -- PF07655 Secretin N-terminal domain GO:0009297 pilus assembly GO:0005488 binding GO:0019867 outer membrane -- -- Cluster-8309.41975 BF_2 31.00 1.23 1341 478253256 ENN73627.1 281 2.3e-22 hypothetical protein YQE_09874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41976 BF_2 825.91 41.04 1129 478253256 ENN73627.1 303 5.4e-25 hypothetical protein YQE_09874, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.41977 BF_2 1033.49 3.96 11213 642910658 XP_008200046.1 10447 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910660|ref|XP_008200047.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910662|ref|XP_008200048.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|642910664|ref|XP_008200049.1| PREDICTED: E3 ubiquitin-protein ligase HUWE1 [Tribolium castaneum]>gi|270014536|gb|EFA10984.1| hypothetical protein TcasGA2_TC004152 [Tribolium castaneum] -- -- -- -- -- K10592 HUWE1, MULE, ARF-BP1 E3 ubiquitin-protein ligase HUWE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10592 Q7Z6Z7 3562 0.0e+00 E3 ubiquitin-protein ligase HUWE1 OS=Homo sapiens GN=HUWE1 PE=1 SV=3 PF10660 Iron-containing outer mitochondrial membrane protein N-terminus GO:0006464 cellular protein modification process GO:0051537 2 iron, 2 sulfur cluster binding GO:0043231 intracellular membrane-bounded organelle KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.41980 BF_2 326.05 4.60 3251 91080077 XP_967815.1 1369 3.8e-148 PREDICTED: gamma-soluble NSF attachment protein [Tribolium castaneum]>gi|270003201|gb|EEZ99648.1| hypothetical protein TcasGA2_TC002405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81127 584 1.7e-58 Gamma-soluble NSF attachment protein OS=Bos taurus GN=NAPG PE=1 SV=3 PF13414//PF13176//PF06552//PF07721//PF00515//PF03930 TPR repeat//Tetratricopeptide repeat//Plant specific mitochondrial import receptor subunit TOM20//Tetratricopeptide repeat//Tetratricopeptide repeat//Recombinase Flp protein N-terminus GO:0006886//GO:0045040//GO:0006310 intracellular protein transport//protein import into mitochondrial outer membrane//DNA recombination GO:0005515//GO:0042802 protein binding//identical protein binding GO:0005742//GO:0005622 mitochondrial outer membrane translocase complex//intracellular KOG1585 Protein required for fusion of vesicles in vesicular transport, gamma-SNAP Cluster-8309.41981 BF_2 60.95 0.73 3784 91080077 XP_967815.1 1036 1.8e-109 PREDICTED: gamma-soluble NSF attachment protein [Tribolium castaneum]>gi|270003201|gb|EEZ99648.1| hypothetical protein TcasGA2_TC002405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81127 363 8.2e-33 Gamma-soluble NSF attachment protein OS=Bos taurus GN=NAPG PE=1 SV=3 PF13414//PF13176//PF03930 TPR repeat//Tetratricopeptide repeat//Recombinase Flp protein N-terminus GO:0006310//GO:0006886 DNA recombination//intracellular protein transport GO:0005515 protein binding GO:0005622 intracellular KOG1585 Protein required for fusion of vesicles in vesicular transport, gamma-SNAP Cluster-8309.41982 BF_2 158.85 1.68 4247 642921997 XP_008192975.1 1073 1.0e-113 PREDICTED: calcium uniporter protein, mitochondrial [Tribolium castaneum] 884952751 XM_013134023.1 63 1.83634e-21 PREDICTED: Esox lucius mitochondrial calcium uniporter (mcu), transcript variant X2, mRNA -- -- -- -- Q08BI9 672 1.4e-68 Calcium uniporter protein, mitochondrial OS=Danio rerio GN=mcu PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2966 Uncharacterized conserved protein Cluster-8309.41984 BF_2 804.83 5.92 5971 642919201 XP_967817.2 3104 0.0e+00 PREDICTED: polycomb protein Sfmbt [Tribolium castaneum] 591292165 XM_007073353.1 60 1.20415e-19 PREDICTED: Panthera tigris altaica transcription factor AP-4 (activating enhancer binding protein 4) (TFAP4), mRNA -- -- -- -- Q29L50 1530 6.2e-168 Polycomb protein Sfmbt OS=Drosophila pseudoobscura pseudoobscura GN=Sfmbt PE=3 SV=2 PF03840//PF00975//PF05577//PF07819//PF08114//PF02198//PF00536//PF02069//PF02820//PF00010//PF07647 Preprotein translocase SecG subunit//Thioesterase domain//Serine carboxypeptidase S28//PGAP1-like protein//ATPase proteolipid family//Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//Prokaryotic metallothionein//mbt repeat//Helix-loop-helix DNA-binding domain//SAM domain (Sterile alpha motif) GO:0006505//GO:0006886//GO:0009306//GO:0006355//GO:0015031//GO:0009058//GO:0006508//GO:0050790 GPI anchor metabolic process//intracellular protein transport//protein secretion//regulation of transcription, DNA-templated//protein transport//biosynthetic process//proteolysis//regulation of catalytic activity GO:0043565//GO:0008236//GO:0030234//GO:0016788//GO:0005515//GO:0046983//GO:0015450//GO:0046872 sequence-specific DNA binding//serine-type peptidase activity//enzyme regulator activity//hydrolase activity, acting on ester bonds//protein binding//protein dimerization activity//P-P-bond-hydrolysis-driven protein transmembrane transporter activity//metal ion binding GO:0009941//GO:0016021//GO:0005634 chloroplast envelope//integral component of membrane//nucleus -- -- Cluster-8309.41987 BF_2 76.23 0.65 5195 270011060 EFA07508.1 3837 0.0e+00 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20742 1226 9.5e-133 Pregnancy zone protein OS=Homo sapiens GN=PZP PE=1 SV=4 PF07678//PF07677//PF01835//PF00207//PF01483//PF00873 A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain//Alpha-2-macroglobulin family//Proprotein convertase P-domain//AcrB/AcrD/AcrF family GO:0006508//GO:0006810 proteolysis//transport GO:0004252//GO:0005215//GO:0004866 serine-type endopeptidase activity//transporter activity//endopeptidase inhibitor activity GO:0005576//GO:0016020//GO:0005615 extracellular region//membrane//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.41988 BF_2 144.93 3.03 2288 546676955 ERL87879.1 737 5.2e-75 hypothetical protein D910_05267 [Dendroctonus ponderosae] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P20350 286 4.2e-24 Protein rhomboid OS=Drosophila melanogaster GN=rho PE=1 SV=2 PF10591//PF13405//PF13833//PF00036//PF13499//PF01694//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//Rhomboid family//EF hand GO:0007165 signal transduction GO:0004252//GO:0005509 serine-type endopeptidase activity//calcium ion binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.41989 BF_2 285.97 16.92 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00106//PF01370//PF02558 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA GO:0055114//GO:0015940//GO:0008152 oxidation-reduction process//pantothenate biosynthetic process//metabolic process GO:0016491//GO:0008677//GO:0003824//GO:0050662 oxidoreductase activity//2-dehydropantoate 2-reductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.41991 BF_2 49.73 0.36 5991 642918310 XP_008191453.1 4768 0.0e+00 PREDICTED: type I inositol 3,4-bisphosphate 4-phosphatase [Tribolium castaneum] -- -- -- -- -- K01109 INPP4 inositol polyphosphate-4-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01109 Q96PE3 739 3.3e-76 Type I inositol 3,4-bisphosphate 4-phosphatase OS=Homo sapiens GN=INPP4A PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG4428 Inositol-polyphosphate 4-phosphatase Cluster-8309.41997 BF_2 59.45 0.55 4849 478251222 ENN71696.1 1228 1.3e-131 hypothetical protein YQE_11619, partial [Dendroctonus ponderosae] 315115388 HQ424723.1 158 3.24919e-74 Euphydryas aurinia ribosomal protein S15 (RpS15) mRNA, complete cds K02958 RP-S15e, RPS15 small subunit ribosomal protein S15e http://www.genome.jp/dbget-bin/www_bget?ko:K02958 Q9W6S3 537 7.0e-53 Target of rapamycin complex 2 subunit MAPKAP1 OS=Gallus gallus GN=MAPKAP1 PE=2 SV=1 PF00203//PF04145//PF00654 Ribosomal protein S19//Ctr copper transporter family//Voltage gated chloride channel GO:0035434//GO:0042254//GO:0055085//GO:0006825//GO:0006821//GO:0006412 copper ion transmembrane transport//ribosome biogenesis//transmembrane transport//copper ion transport//chloride transport//translation GO:0003735//GO:0005247//GO:0005375 structural constituent of ribosome//voltage-gated chloride channel activity//copper ion transmembrane transporter activity GO:0005840//GO:0016020//GO:0016021 ribosome//membrane//integral component of membrane KOG0898 40S ribosomal protein S15 Cluster-8309.41998 BF_2 10.15 0.69 907 170321837 BAG14263.1 169 1.5e-09 GNBP1 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00353 Hemolysin-type calcium-binding repeat (2 copies) -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.42003 BF_2 502.90 12.50 1970 642933218 XP_008197312.1 1186 3.8e-127 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O61369 762 2.3e-79 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.42004 BF_2 97.53 3.79 1363 332374670 AEE62476.1 724 9.9e-74 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9LZG0 383 1.4e-35 Adenosine kinase 2 OS=Arabidopsis thaliana GN=ADK2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.42005 BF_2 40.06 0.50 3620 270297180 NP_001161912.1 858 7.6e-89 cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|268309002|gb|ACY95467.1| cuticular protein analogous to peritrophins 1-B [Tribolium castaneum]>gi|270001714|gb|EEZ98161.1| hypothetical protein TcasGA2_TC000587 [Tribolium castaneum] 817213894 XM_012427772.1 132 6.87143e-60 PREDICTED: Orussus abietinus uncharacterized LOC105701218 (LOC105701218), mRNA -- -- -- -- -- -- -- -- PF01607//PF02975 Chitin binding Peritrophin-A domain//Methylamine dehydrogenase, L chain GO:0009308//GO:0055114//GO:0006030 amine metabolic process//oxidation-reduction process//chitin metabolic process GO:0016638//GO:0008061 oxidoreductase activity, acting on the CH-NH2 group of donors//chitin binding GO:0042597//GO:0005576 periplasmic space//extracellular region -- -- Cluster-8309.42006 BF_2 1094.14 14.33 3482 571568658 XP_006565113.1 332 7.2e-28 PREDICTED: optineurin isoform X2 [Apis mellifera] -- -- -- -- -- -- -- -- -- O88522 187 1.9e-12 NF-kappa-B essential modulator OS=Mus musculus GN=Ikbkg PE=1 SV=2 PF00096//PF10186//PF13851//PF08287//PF02183//PF06160//PF13912//PF07651 Zinc finger, C2H2 type//Vacuolar sorting 38 and autophagy-related subunit 14//Growth-arrest specific micro-tubule binding//Spc19//Homeobox associated leucine zipper//Septation ring formation regulator, EzrA//C2H2-type zinc finger//ANTH domain GO:0010508//GO:0006355//GO:0008608//GO:0000921//GO:0048870 positive regulation of autophagy//regulation of transcription, DNA-templated//attachment of spindle microtubules to kinetochore//septin ring assembly//cell motility GO:0046872//GO:0003700//GO:0043565//GO:0005543 metal ion binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//phospholipid binding GO:0005876//GO:0042729//GO:0005940//GO:0005667//GO:0031514//GO:0016021 spindle microtubule//DASH complex//septin ring//transcription factor complex//motile cilium//integral component of membrane -- -- Cluster-8309.42008 BF_2 1.00 0.43 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42009 BF_2 24.14 0.39 2905 642938243 XP_008198126.1 655 2.1e-65 PREDICTED: serine/threonine-protein kinase Doa isoform X1 [Tribolium castaneum] -- -- -- -- -- K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 494 4.0e-48 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 PF10399 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal GO:0055114//GO:0006119//GO:0015992//GO:0006118 oxidation-reduction process//oxidative phosphorylation//proton transport//obsolete electron transport GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- KOG0671 LAMMER dual specificity kinases Cluster-8309.42010 BF_2 38.51 3.00 825 642938247 XP_008198128.1 529 2.4e-51 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 58 2.07731e-19 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA K08823 CLK CDC-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08823 P49762 176 8.6e-12 Serine/threonine-protein kinase Doa OS=Drosophila melanogaster GN=Doa PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0671 LAMMER dual specificity kinases Cluster-8309.42011 BF_2 479.04 24.53 1104 91081585 XP_975324.1 393 1.9e-35 PREDICTED: protein FAM177A1 [Tribolium castaneum]>gi|270005105|gb|EFA01553.1| hypothetical protein TcasGA2_TC007114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QLZ5 227 1.4e-17 Protein FAM177A1 OS=Bos taurus GN=FAM177A1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42012 BF_2 73.00 1.59 2204 270013588 EFA10036.1 161 3.1e-08 hypothetical protein TcasGA2_TC012208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02792 Mago nashi protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.42014 BF_2 150.17 1.23 5399 642937831 XP_008200319.1 4126 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1078 1.4e-115 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF00397//PF13180//PF00595 WW domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.42015 BF_2 682.10 6.75 4512 478262128 ENN81013.1 2054 2.0e-227 hypothetical protein YQE_02575, partial [Dendroctonus ponderosae]>gi|546672857|gb|ERL84580.1| hypothetical protein D910_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86SQ0 529 5.5e-52 Pleckstrin homology-like domain family B member 2 OS=Homo sapiens GN=PHLDB2 PE=1 SV=2 PF11770//PF07926//PF00498 GRB2-binding adapter (GAPT)//TPR/MLP1/MLP2-like protein//FHA domain GO:0006606 protein import into nucleus GO:0005515 protein binding GO:0016021 integral component of membrane KOG0245 Kinesin-like protein Cluster-8309.42016 BF_2 36.89 1.74 1175 328698759 XP_003240725.1 137 9.9e-06 PREDICTED: serine/arginine repetitive matrix protein 2-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42017 BF_2 6.00 19.37 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42018 BF_2 102.46 2.46 2030 642930948 XP_008196153.1 1518 1.3e-165 PREDICTED: protein diaphanous isoform X3 [Tribolium castaneum] 642930947 XM_008197931.1 56 6.77525e-18 PREDICTED: Tribolium castaneum protein diaphanous (LOC660495), transcript variant X3, mRNA K05740 DIAPH1 diaphanous 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05740 P48608 771 2.1e-80 Protein diaphanous OS=Drosophila melanogaster GN=dia PE=2 SV=2 PF06371//PF06367//PF10508 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain//Proteasome non-ATPase 26S subunit GO:0030036//GO:0016043//GO:0043248 actin cytoskeleton organization//cellular component organization//proteasome assembly GO:0017048//GO:0003779 Rho GTPase binding//actin binding -- -- KOG2691 RNA polymerase II subunit 9 Cluster-8309.42021 BF_2 99.15 0.67 6493 642918222 XP_008191418.1 4592 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X1 [Tribolium castaneum]>gi|270003291|gb|EEZ99738.1| hypothetical protein TcasGA2_TC002507 [Tribolium castaneum] 795022714 XM_012005302.1 542 0 PREDICTED: Vollenhovia emeryi transcription initiation factor TFIID subunit 1 (LOC105557903), mRNA K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 P51123 3568 0.0e+00 Transcription initiation factor TFIID subunit 1 OS=Drosophila melanogaster GN=Taf1 PE=1 SV=3 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.42022 BF_2 8.00 0.56 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115 SFI toxin family GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.42023 BF_2 390.94 5.30 3374 91093076 XP_968784.1 903 4.3e-94 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] 195036913 XM_001989877.1 35 5.34771e-06 Drosophila grimshawi GH18533 (Dgri\GH18533), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 844 1.2e-88 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42024 BF_2 264.55 10.72 1320 642926079 XP_008194755.1 840 3.4e-87 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 522 1.0e-51 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106//PF04406//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase//Type IIB DNA topoisomerase//NAD dependent epimerase/dehydratase family GO:0006259//GO:0055114//GO:0008152 DNA metabolic process//oxidation-reduction process//metabolic process GO:0003677//GO:0050662//GO:0003824//GO:0005524//GO:0016491 DNA binding//coenzyme binding//catalytic activity//ATP binding//oxidoreductase activity GO:0005694 chromosome -- -- Cluster-8309.42025 BF_2 1678.81 20.82 3660 91086687 XP_969129.1 2459 1.7e-274 PREDICTED: tyrosine-protein kinase Src42A isoform X2 [Tribolium castaneum] 242015483 XM_002428338.1 244 3.81426e-122 Pediculus humanus corporis tyrosine-protein kinase Src42A, putative, mRNA K08892 FRK, PTK5 fyn-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08892 Q9V9J3 2167 5.2e-242 Tyrosine-protein kinase Src42A OS=Drosophila melanogaster GN=Src42A PE=2 SV=1 PF07714//PF00018//PF14604//PF00069//PF06293 Protein tyrosine kinase//SH3 domain//Variant SH3 domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524//GO:0016773 protein kinase activity//protein binding//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0197 Tyrosine kinases Cluster-8309.42026 BF_2 255.47 2.42 4698 642928846 XP_008195586.1 2003 1.7e-221 PREDICTED: tyrosine-protein kinase Src42A isoform X1 [Tribolium castaneum] 242015483 XM_002428338.1 244 4.90675e-122 Pediculus humanus corporis tyrosine-protein kinase Src42A, putative, mRNA K08892 FRK, PTK5 fyn-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08892 Q9V9J3 1803 1.1e-199 Tyrosine-protein kinase Src42A OS=Drosophila melanogaster GN=Src42A PE=2 SV=1 PF07714//PF00069//PF02043 Protein tyrosine kinase//Protein kinase domain//Bacteriochlorophyll C binding protein GO:0006468//GO:0015979 protein phosphorylation//photosynthesis GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0197 Tyrosine kinases Cluster-8309.42027 BF_2 104.44 16.68 549 478258333 ENN78452.1 570 2.9e-56 hypothetical protein YQE_05090, partial [Dendroctonus ponderosae]>gi|546677055|gb|ERL87964.1| hypothetical protein D910_05352 [Dendroctonus ponderosae] 806777497 KP219380.1 68 3.7339e-25 Paroster nigroadumbratus long-wavelength opsin (lwop) mRNA, partial cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 P35362 480 3.2e-47 Rhodopsin OS=Sphodromantis sp. PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.4203 BF_2 3.00 0.81 442 674304042 AIL23552.1 216 2.6e-15 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q2NL00 147 1.1e-08 Glutathione S-transferase theta-1 OS=Bos taurus GN=GSTT1 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42030 BF_2 8.76 1.99 471 642935298 XP_008197956.1 191 2.2e-12 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42031 BF_2 125.56 0.97 5679 642935312 XP_008197963.1 2061 3.8e-228 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X12 [Tribolium castaneum] 780158183 XM_011684374.1 51 1.15303e-14 PREDICTED: Strongylocentrotus purpuratus CAP-Gly domain-containing linker protein 1 (LOC594474), transcript variant X6, mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 1122 1.2e-120 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF10186//PF08702//PF00038 Vacuolar sorting 38 and autophagy-related subunit 14//Fibrinogen alpha/beta chain family//Intermediate filament protein GO:0051258//GO:0007165//GO:0010508//GO:0030168 protein polymerization//signal transduction//positive regulation of autophagy//platelet activation GO:0005198//GO:0005102//GO:0030674 structural molecule activity//receptor binding//protein binding, bridging GO:0005882//GO:0005577 intermediate filament//fibrinogen complex -- -- Cluster-8309.42035 BF_2 402.00 29.36 860 282158103 NP_001164095.1 1352 9.4e-147 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 194745413 XM_001955147.1 254 2.40163e-128 Drosophila ananassae GF18634 (Dana\GF18634), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1115 1.2e-120 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003677//GO:0016787//GO:0003676 ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.42038 BF_2 213.00 5.56 1890 780653482 XP_011691002.1 2477 7.3e-277 PREDICTED: tRNA-splicing ligase RtcB homolog [Wasmannia auropunctata] 752874085 XM_011256048.1 451 0 PREDICTED: Camponotus floridanus tRNA-splicing ligase RtcB homolog (LOC105250110), mRNA K14415 RTCB, rtcB tRNA-splicing ligase RtcB http://www.genome.jp/dbget-bin/www_bget?ko:K14415 Q9VIW7 2423 5.5e-272 tRNA-splicing ligase RtcB homolog OS=Drosophila melanogaster GN=CG9987 PE=2 SV=1 PF01139 tRNA-splicing ligase RtcB GO:0006396 RNA processing GO:0008452 RNA ligase activity -- -- KOG3833 Uncharacterized conserved protein, contains RtcB domain Cluster-8309.42039 BF_2 516.91 7.08 3340 642934154 XP_008199630.1 1009 2.2e-106 PREDICTED: telomerase reverse transcriptase isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009 Telomerase ribonucleoprotein complex - RNA binding domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- -- -- Cluster-8309.42040 BF_2 79.11 0.71 4923 332376376 AEE63328.1 726 2.1e-73 unknown [Dendroctonus ponderosae]>gi|546675031|gb|ERL86292.1| hypothetical protein D910_03700 [Dendroctonus ponderosae] -- -- -- -- -- K01493 comEB dCMP deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01493 P32321 580 7.3e-58 Deoxycytidylate deaminase OS=Homo sapiens GN=DCTD PE=1 SV=2 PF03261//PF00383 Cyclin-dependent kinase 5 activator protein//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0045859 regulation of protein kinase activity GO:0008270//GO:0016534 zinc ion binding//cyclin-dependent protein kinase 5 activator activity GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex KOG3127 Deoxycytidylate deaminase Cluster-8309.42041 BF_2 6.00 2.20 400 189236433 XP_972706.2 152 6.1e-08 PREDICTED: nuclear transcription factor Y subunit alpha isoform X1 [Tribolium castaneum]>gi|270005402|gb|EFA01850.1| hypothetical protein TcasGA2_TC007453 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0016602//GO:0005667 CCAAT-binding factor complex//transcription factor complex -- -- Cluster-8309.42043 BF_2 1.00 8.68 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42046 BF_2 1062.64 5.28 8704 642924084 XP_008193999.1 5676 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X1 [Tribolium castaneum] 642924089 XM_008195780.1 744 0 PREDICTED: Tribolium castaneum mediator of RNA polymerase II transcription subunit 12 (LOC656353), transcript variant X4, mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q86YW9 2448 3.2e-274 Mediator of RNA polymerase II transcription subunit 12-like protein OS=Homo sapiens GN=MED12L PE=1 SV=2 PF09497 Transcription mediator complex subunit Med12 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.42049 BF_2 141.58 0.73 8356 642913355 XP_008195386.1 6061 0.0e+00 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K11757 PBRM1, PB1 protein polybromo-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11757 Q86U86 1886 4.5e-209 Protein polybromo-1 OS=Homo sapiens GN=PBRM1 PE=1 SV=1 PF07728//PF07726//PF00158//PF00493//PF00004//PF00439//PF01426 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//Bromodomain//BAH domain GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0005515//GO:0008134//GO:0005524//GO:0003677//GO:0003682//GO:0016887 protein binding//transcription factor binding//ATP binding//DNA binding//chromatin binding//ATPase activity GO:0005667//GO:0000785 transcription factor complex//chromatin KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.4205 BF_2 14.00 0.56 1336 861611173 KMQ85248.1 412 1.5e-37 nuclease harbi1 [Lasius niger] -- -- -- -- -- -- -- -- -- Q96MB7 170 6.9e-11 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF02319//PF04827//PF01609 E2F/DP family winged-helix DNA-binding domain//Plant transposon protein//Transposase DDE domain GO:0006355//GO:0006313 regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803//GO:0003700 DNA binding//hydrolase activity, acting on ester bonds//transposase activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42050 BF_2 387.33 9.42 2008 642925384 XP_008194526.1 2481 2.7e-277 PREDICTED: LOW QUALITY PROTEIN: transformation/transcription domain-associated protein [Tribolium castaneum] 241056114 XM_002407701.1 98 3.00911e-41 Ixodes scapularis transformation/transcription domain-associated protein, putative, mRNA K08874 TRRAP transformation/transcription domain-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K08874 Q9Y4A5 1905 6.8e-212 Transformation/transcription domain-associated protein OS=Homo sapiens GN=TRRAP PE=1 SV=3 PF00454//PF02260 Phosphatidylinositol 3- and 4-kinase//FATC domain -- -- GO:0005515//GO:0016773 protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0889 Histone acetyltransferase SAGA, TRRAP/TRA1 component, PI-3 kinase superfamily Cluster-8309.42051 BF_2 149.00 2.80 2510 91082353 XP_967422.1 3058 0.0e+00 PREDICTED: DNA replication licensing factor Mcm7 [Tribolium castaneum]>gi|270007172|gb|EFA03620.1| hypothetical protein TcasGA2_TC013713 [Tribolium castaneum] 780092378 XM_011675888.1 72 1.07203e-26 PREDICTED: Strongylocentrotus purpuratus DNA replication licensing factor mcm7-A (LOC574771), transcript variant X2, mRNA K02210 MCM7, CDC47 DNA replication licensing factor MCM7 http://www.genome.jp/dbget-bin/www_bget?ko:K02210 Q9XYU0 2687 1.8e-302 DNA replication licensing factor Mcm7 OS=Drosophila melanogaster GN=Mcm7 PE=1 SV=1 PF00493//PF00285//PF07728//PF07726 MCM2/3/5 family//Citrate synthase//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006270//GO:0006260 DNA replication initiation//DNA replication GO:0046912//GO:0003677//GO:0005524//GO:0017111//GO:0016887 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer//DNA binding//ATP binding//nucleoside-triphosphatase activity//ATPase activity GO:0005634 nucleus KOG0482 DNA replication licensing factor, MCM7 component Cluster-8309.42052 BF_2 1078.53 68.17 949 91086581 XP_973438.1 1079 4.7e-115 PREDICTED: derlin-1 [Tribolium castaneum]>gi|270010357|gb|EFA06805.1| hypothetical protein TcasGA2_TC009744 [Tribolium castaneum] -- -- -- -- -- K11519 DERL1 Derlin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11519 Q5R9W3 805 1.1e-84 Derlin-1 OS=Pongo abelii GN=DERL1 PE=2 SV=1 PF04505//PF01694 Interferon-induced transmembrane protein//Rhomboid family GO:0009607 response to biotic stimulus GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG0858 Predicted membrane protein Cluster-8309.42054 BF_2 91.13 4.28 1178 270011709 EFA08157.1 164 7.4e-09 hypothetical protein TcasGA2_TC005777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10471 Anaphase-promoting complex APC subunit CDC26 GO:0030071//GO:0031145 regulation of mitotic metaphase/anaphase transition//anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process -- -- GO:0005680 anaphase-promoting complex -- -- Cluster-8309.42056 BF_2 26.98 0.39 3182 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42058 BF_2 272.35 4.78 2673 642913783 XP_008201159.1 2257 3.4e-251 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 8.83309e-28 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 2053 6.2e-229 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF10462//PF00413 Peptidase M66//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.42059 BF_2 196.43 1.49 5813 642913783 XP_008201159.1 1313 2.1e-141 PREDICTED: ADAM 17-like protease isoform X1 [Tribolium castaneum] 662209356 XM_008480054.1 74 1.93376e-27 PREDICTED: Diaphorina citri ADAM 17-like protease (LOC103515131), mRNA K06059 ADAM17, TACE disintegrin and metalloproteinase domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K06059 Q9VAC5 1200 1.1e-129 ADAM 17-like protease OS=Drosophila melanogaster GN=Tace PE=2 SV=2 PF04750//PF01562//PF03611 FAR-17a/AIG1-like protein//Reprolysin family propeptide//PTS system sugar-specific permease component GO:0006508//GO:0009401 proteolysis//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.42062 BF_2 598.91 5.31 5007 642910889 XP_008193451.1 4292 0.0e+00 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X1 [Tribolium castaneum] 805778458 XM_012283126.1 285 8.45067e-145 PREDICTED: Megachile rotundata SLIT-ROBO Rho GTPase-activating protein 1 (LOC100883803), transcript variant X1, mRNA K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 Q7Z6B7 1641 6.9e-181 SLIT-ROBO Rho GTPase-activating protein 1 OS=Homo sapiens GN=SRGAP1 PE=1 SV=1 PF09177//PF14604//PF00620//PF00018//PF16740//PF02321 Syntaxin 6, N-terminal//Variant SH3 domain//RhoGAP domain//SH3 domain//Spindle and kinetochore-associated protein 2//Outer membrane efflux protein GO:0000090//GO:0007067//GO:0051301//GO:0031110//GO:0007059//GO:0007165//GO:0006810//GO:0048193 mitotic anaphase//mitotic nuclear division//cell division//regulation of microtubule polymerization or depolymerization//chromosome segregation//signal transduction//transport//Golgi vesicle transport GO:0008017//GO:0005215//GO:0005515 microtubule binding//transporter activity//protein binding GO:0016020//GO:0000940//GO:0005876//GO:0045298 membrane//condensed chromosome outer kinetochore//spindle microtubule//tubulin complex -- -- Cluster-8309.42064 BF_2 1123.02 77.16 896 642927566 XP_972340.2 566 1.4e-55 PREDICTED: 40S ribosomal protein S12 [Tribolium castaneum] -- -- -- -- -- K02951 RP-S12e, RPS12 small subunit ribosomal protein S12e http://www.genome.jp/dbget-bin/www_bget?ko:K02951 P80455 427 7.3e-41 40S ribosomal protein S12 OS=Drosophila melanogaster GN=RpS12 PE=1 SV=2 PF02065 Melibiase GO:0046486//GO:0005975//GO:0001575//GO:0006012 glycerolipid metabolic process//carbohydrate metabolic process//globoside metabolic process//galactose metabolic process GO:0004557 alpha-galactosidase activity -- -- KOG3406 40S ribosomal protein S12 Cluster-8309.42065 BF_2 85.00 1.59 2529 642919579 XP_008191929.1 297 6.0e-24 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42066 BF_2 380.61 9.80 1912 91088923 XP_973277.1 1071 8.0e-114 PREDICTED: lysophospholipid acyltransferase 7 [Tribolium castaneum] -- -- -- -- -- K13516 MBOAT7 lysophospholipid acyltransferase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13516 Q5U4T9 604 4.7e-61 Lysophospholipid acyltransferase 7 OS=Xenopus laevis GN=mboat7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2706 Predicted membrane protein Cluster-8309.42070 BF_2 4.62 0.34 858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42074 BF_2 1444.70 26.37 2579 642919846 XP_008192093.1 650 7.1e-65 PREDICTED: lipid storage droplets surface-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 218 3.6e-16 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 PF05459 Herpesvirus transcriptional regulator family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.42076 BF_2 307.77 4.12 3409 189240845 XP_001812763.1 3345 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 393809286 JQ824200.1 482 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 2321 6.7e-260 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF01602//PF02985//PF02883//PF08367 Adaptin N terminal region//HEAT repeat//Adaptin C-terminal domain//Peptidase M16C associated GO:0016192//GO:0006886//GO:0006508 vesicle-mediated transport//intracellular protein transport//proteolysis GO:0005515 protein binding GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.42078 BF_2 907.99 8.54 4735 642926029 XP_969555.3 1934 1.7e-213 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 3.45329e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 2.9e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42080 BF_2 128.23 0.65 8504 642911051 XP_008200619.1 8610 0.0e+00 PREDICTED: HEAT repeat-containing protein 5B isoform X1 [Tribolium castaneum] 549438536 KC282400.1 192 7.18548e-93 Leptinotarsa decemlineata clone 18-9298 disulfide-isomerase mRNA, partial cds -- -- -- -- Q9P2D3 5357 0.0e+00 HEAT repeat-containing protein 5B OS=Homo sapiens GN=HEATR5B PE=1 SV=2 PF00578//PF00514//PF00085//PF02985//PF08785 AhpC/TSA family//Armadillo/beta-catenin-like repeat//Thioredoxin//HEAT repeat//Ku C terminal domain like GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0005515//GO:0016491//GO:0016817 antioxidant activity//protein binding//oxidoreductase activity//hydrolase activity, acting on acid anhydrides -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.42081 BF_2 86.60 0.52 7268 270007094 EFA03542.1 5470 0.0e+00 hypothetical protein TcasGA2_TC013545 [Tribolium castaneum] 697831268 XM_009637705.1 186 1.32833e-89 PREDICTED: Egretta garzetta UDP-glucose glycoprotein glucosyltransferase 2 (UGGT2), mRNA K11718 HUGT UDP-glucose:glycoprotein glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11718 Q09332 3667 0.0e+00 UDP-glucose:glycoprotein glucosyltransferase OS=Drosophila melanogaster GN=Ugt PE=1 SV=2 PF00230//PF06427//PF00110//PF01501 Major intrinsic protein//UDP-glucose:Glycoprotein Glucosyltransferase//wnt family//Glycosyl transferase family 8 GO:0006486//GO:0007165//GO:0007275//GO:0016055//GO:0006810 protein glycosylation//signal transduction//multicellular organismal development//Wnt signaling pathway//transport GO:0005102//GO:0016757//GO:0005215//GO:0003980 receptor binding//transferase activity, transferring glycosyl groups//transporter activity//UDP-glucose:glycoprotein glucosyltransferase activity GO:0005576//GO:0016020 extracellular region//membrane KOG1879 UDP-glucose:glycoprotein glucosyltransferase Cluster-8309.42082 BF_2 220.66 0.81 11703 91083299 XP_974608.1 2229 2.6e-247 PREDICTED: DET1 homolog [Tribolium castaneum]>gi|270006938|gb|EFA03386.1| hypothetical protein TcasGA2_TC013372 [Tribolium castaneum] -- -- -- -- -- K10571 DET1 de-etiolated-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10571 Q9D0A0 1751 2.9e-193 DET1 homolog OS=Mus musculus GN=Det1 PE=2 SV=2 PF01695//PF06414//PF00004//PF06309//PF11057 IstB-like ATP binding protein//Zeta toxin//ATPase family associated with various cellular activities (AAA)//Torsin//Cortexin of kidney -- -- GO:0016301//GO:0005524 kinase activity//ATP binding GO:0031224 intrinsic component of membrane KOG2558 Negative regulator of histones Cluster-8309.42085 BF_2 563.52 16.73 1696 642912938 XP_008201315.1 653 2.1e-65 PREDICTED: antichymotrypsin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 448 5.1e-43 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42086 BF_2 16.37 0.76 1184 264667459 ACY71315.1 524 1.3e-50 ribosomal protein L28 [Chrysomela tremula] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 427 9.7e-41 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-8309.42087 BF_2 498.27 14.15 1760 642912938 XP_008201315.1 653 2.2e-65 PREDICTED: antichymotrypsin-2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 448 5.3e-43 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42089 BF_2 135.87 0.86 6877 642911463 XP_008199434.1 1032 9.6e-109 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF03323//PF15220 MAP7 (E-MAP-115) family//Bacillus/Clostridium GerA spore germination protein//Hypoxia-inducible lipid droplet-associated GO:0001819//GO:0000226//GO:0010884//GO:0009847//GO:0008284 positive regulation of cytokine production//microtubule cytoskeleton organization//positive regulation of lipid storage//spore germination//positive regulation of cell proliferation -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.42090 BF_2 251.01 2.62 4296 478261443 ENN80813.1 1898 2.3e-209 hypothetical protein YQE_02770, partial [Dendroctonus ponderosae]>gi|546676399|gb|ERL87419.1| hypothetical protein D910_04814 [Dendroctonus ponderosae] 462382197 APGK01021748.1 140 2.91684e-64 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence -- -- -- -- Q6NYE2 1081 5.1e-116 Protein RCC2 homolog OS=Danio rerio GN=rcc2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.42091 BF_2 389.67 3.07 5589 478256475 ENN76660.1 630 3.2e-62 hypothetical protein YQE_06839, partial [Dendroctonus ponderosae] -- -- -- -- -- K12887 HNRNPM heterogeneous nuclear ribonucleoprotein M http://www.genome.jp/dbget-bin/www_bget?ko:K12887 Q9D0E1 281 3.9e-23 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus GN=Hnrnpm PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4212 RNA-binding protein hnRNP-M Cluster-8309.42097 BF_2 318.39 2.61 5399 478255296 ENN75522.1 1701 2.0e-186 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 3.6e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 PF01278 Omptin family GO:0006508 proteolysis GO:0004175 endopeptidase activity GO:0009279 cell outer membrane KOG1304 Amino acid transporters Cluster-8309.42098 BF_2 121.45 0.99 5394 478255296 ENN75522.1 1701 2.0e-186 hypothetical protein YQE_07866, partial [Dendroctonus ponderosae]>gi|546683150|gb|ERL93001.1| hypothetical protein D910_10303 [Dendroctonus ponderosae] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 583 3.6e-58 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 PF01278 Omptin family GO:0006508 proteolysis GO:0004175 endopeptidase activity GO:0009279 cell outer membrane KOG1304 Amino acid transporters Cluster-8309.421 BF_2 11.00 0.35 1602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42100 BF_2 257.84 2.02 5628 478255117 ENN75347.1 1050 6.4e-111 hypothetical protein YQE_08123, partial [Dendroctonus ponderosae] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 O01735 608 4.7e-61 Uncharacterized MFS-type transporter C09D4.1 OS=Caenorhabditis elegans GN=C09D4.1 PE=3 SV=2 PF10640//PF07690 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase//Major Facilitator Superfamily GO:0006370//GO:0055085 7-methylguanosine mRNA capping//transmembrane transport GO:0004484//GO:0004651 mRNA guanylyltransferase activity//polynucleotide 5'-phosphatase activity GO:0016021 integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.42101 BF_2 48.39 0.67 3320 478255117 ENN75347.1 919 5.9e-96 hypothetical protein YQE_08123, partial [Dendroctonus ponderosae] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q9UPI3 534 1.1e-52 Feline leukemia virus subgroup C receptor-related protein 2 OS=Homo sapiens GN=FLVCR2 PE=1 SV=1 PF10640//PF03137//PF07690 mRNA capping enzyme N-terminal, ATPase and guanylyltransferase//Organic Anion Transporter Polypeptide (OATP) family//Major Facilitator Superfamily GO:0006370//GO:0006810//GO:0055085 7-methylguanosine mRNA capping//transport//transmembrane transport GO:0004651//GO:0004484//GO:0005215 polynucleotide 5'-phosphatase activity//mRNA guanylyltransferase activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.42103 BF_2 255.71 5.80 2130 91092778 XP_973837.1 667 6.3e-67 PREDICTED: BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 [Tribolium castaneum]>gi|270014896|gb|EFA11344.1| hypothetical protein TcasGA2_TC010884 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06553 BNIP3 GO:0043065 positive regulation of apoptotic process -- -- GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.42104 BF_2 1618.06 7.36 9486 642922507 XP_008193202.1 10522 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR5 isoform X1 [Tribolium castaneum] 195499541 XM_002096957.1 85 2.42708e-33 Drosophila yakuba hyd (Dyak\hyd), partial mRNA K10593 EDD1, UBR5 E3 ubiquitin-protein ligase EDD1 http://www.genome.jp/dbget-bin/www_bget?ko:K10593 P51592 1894 6.1e-210 E3 ubiquitin-protein ligase hyd OS=Drosophila melanogaster GN=hyd PE=1 SV=3 PF11547//PF04625//PF00632//PF00658 E3 ubiquitin ligase EDD//DEC-1 protein, N-terminal region//HECT-domain (ubiquitin-transferase)//Poly-adenylate binding protein, unique domain GO:0007304//GO:0016567 chorion-containing eggshell formation//protein ubiquitination GO:0004842//GO:0003723//GO:0005213//GO:0043130 ubiquitin-protein transferase activity//RNA binding//structural constituent of chorion//ubiquitin binding GO:0042600//GO:0005576 chorion//extracellular region KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.42107 BF_2 689.32 20.17 1717 642937622 XP_008199126.1 1008 1.5e-106 PREDICTED: probable cytochrome P450 6a13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q964R1 773 1.1e-80 Cytochrome P450 6j1 OS=Blattella germanica GN=CYP6J1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.42108 BF_2 148.68 0.91 7140 642928768 XP_008195553.1 4946 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 342356458 JF265057.1 79 3.94932e-30 Heliconius melpomene cythera ribosomal protein L29 (RpL29) mRNA, complete cds K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 A1A4J6 3572 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Bos taurus GN=ATP9B PE=2 SV=1 PF12861//PF07926//PF17123//PF12678//PF07851//PF00628//PF14634//PF11365//PF00769//PF13639//PF15898//PF16685//PF01166//PF10473//PF00122//PF01779//PF00097 Anaphase-promoting complex subunit 11 RING-H2 finger//TPR/MLP1/MLP2-like protein//RING-like zinc finger//RING-H2 zinc finger//TMPIT-like protein//PHD-finger//zinc-RING finger domain//Protein of unknown function (DUF3166)//Ezrin/radixin/moesin family//Ring finger domain//cGMP-dependent protein kinase interacting domain//zinc RING finger of MSL2//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//E1-E2 ATPase//Ribosomal L29e protein family//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0006412//GO:0010506//GO:0042254//GO:0006355//GO:0006606 protein ubiquitination//translation//regulation of autophagy//ribosome biogenesis//regulation of transcription, DNA-templated//protein import into nucleus GO:0004842//GO:0061630//GO:0005515//GO:0008092//GO:0046872//GO:0042803//GO:0045502//GO:0008134//GO:0003700//GO:0000166//GO:0008270//GO:0003735//GO:0019901 ubiquitin-protein transferase activity//ubiquitin protein ligase activity//protein binding//cytoskeletal protein binding//metal ion binding//protein homodimerization activity//dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//nucleotide binding//zinc ion binding//structural constituent of ribosome//protein kinase binding GO:0005667//GO:0005680//GO:0030286//GO:0016021//GO:0019898//GO:0005615//GO:0005737//GO:0005840//GO:0005622 transcription factor complex//anaphase-promoting complex//dynein complex//integral component of membrane//extrinsic component of membrane//extracellular space//cytoplasm//ribosome//intracellular KOG0210 P-type ATPase Cluster-8309.42112 BF_2 2865.38 11.30 10892 642930447 XP_008196405.1 785 6.7e-80 PREDICTED: synaptosomal-associated protein 25 isoform X4 [Tribolium castaneum]>gi|270010729|gb|EFA07177.1| hypothetical protein TcasGA2_TC010177 [Tribolium castaneum] 642930446 XM_008198183.1 269 1.44641e-135 PREDICTED: Tribolium castaneum synaptosomal-associated protein 25 (LOC663588), transcript variant X4, mRNA K18211 SNAP25 synaptosomal-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K18211 P36975 708 2.3e-72 Synaptosomal-associated protein 25 OS=Drosophila melanogaster GN=Snap25 PE=2 SV=1 PF01292//PF03419 Prokaryotic cytochrome b561//Sporulation factor SpoIIGA GO:0030436//GO:0006118//GO:0006508 asexual sporulation//obsolete electron transport//proteolysis GO:0009055//GO:0004190 electron carrier activity//aspartic-type endopeptidase activity GO:0043005//GO:0016021 neuron projection//integral component of membrane KOG3065 SNAP-25 (synaptosome-associated protein) component of SNARE complex Cluster-8309.42116 BF_2 143.51 1.91 3431 642936574 XP_008198491.1 1031 6.3e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 3.0e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF10590//PF01243//PF12766//PF08241//PF05175//PF02252//PF03602//PF02251 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Methyltransferase domain//Methyltransferase small domain//Proteasome activator pa28 beta subunit//Conserved hypothetical protein 95//Proteasome activator pa28 alpha subunit GO:0031167//GO:0008152//GO:0055114//GO:0008615 rRNA methylation//metabolic process//oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0010181//GO:0016638//GO:0008168 pyridoxamine-phosphate oxidase activity//FMN binding//oxidoreductase activity, acting on the CH-NH2 group of donors//methyltransferase activity GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.42117 BF_2 659.24 15.70 2044 642936574 XP_008198491.1 1031 3.7e-109 PREDICTED: proteasome activator complex subunit 3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06698 PSME3 proteasome activator subunit 3 (PA28 gamma) http://www.genome.jp/dbget-bin/www_bget?ko:K06698 Q5RFD3 651 1.8e-66 Proteasome activator complex subunit 3 OS=Pongo abelii GN=PSME3 PE=2 SV=1 PF02252//PF01243//PF12766//PF02251 Proteasome activator pa28 beta subunit//Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//Proteasome activator pa28 alpha subunit GO:0055114//GO:0008615 oxidation-reduction process//pyridoxine biosynthetic process GO:0004733//GO:0010181 pyridoxamine-phosphate oxidase activity//FMN binding GO:0008537 proteasome activator complex KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.42120 BF_2 150.79 2.77 2566 91078780 XP_969394.1 1583 4.6e-173 PREDICTED: nedd8-activating enzyme E1 regulatory subunit [Tribolium castaneum]>gi|270004104|gb|EFA00552.1| hypothetical protein TcasGA2_TC003419 [Tribolium castaneum] -- -- -- -- -- K04532 APPBP1 amyloid beta precursor protein binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04532 Q7SXP2 892 2.5e-94 NEDD8-activating enzyme E1 regulatory subunit OS=Danio rerio GN=nae1 PE=2 SV=2 PF05104//PF01210//PF08041//PF00125//PF08036//PF13413 Ribosome receptor lysine/proline rich region//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//PetM family of cytochrome b6f complex subunit 7//Core histone H2A/H2B/H3/H4//Diapausin family of antimicrobial peptide//Helix-turn-helix domain GO:0015031//GO:0055114//GO:0046168//GO:0008152//GO:0050832 protein transport//oxidation-reduction process//glycerol-3-phosphate catabolic process//metabolic process//defense response to fungus GO:0000166//GO:0003677//GO:0003824//GO:0051287//GO:0016616 nucleotide binding//DNA binding//catalytic activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005576//GO:0030176//GO:0009512 extracellular region//integral component of endoplasmic reticulum membrane//cytochrome b6f complex KOG2016 NEDD8-activating complex, APP-BP1/UBA5 component Cluster-8309.42122 BF_2 3623.06 33.74 4779 546672885 ERL84608.1 3593 0.0e+00 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1470 4.5e-161 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00107//PF00108//PF08545 Zinc-binding dehydrogenase//Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0008152//GO:0006633//GO:0042967//GO:0055114 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process//oxidation-reduction process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.42124 BF_2 1310.38 41.25 1616 642910507 XP_008200244.1 1345 1.1e-145 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] 462373318 APGK01024789.1 75 1.47188e-28 Dendroctonus ponderosae Seq01024799, whole genome shotgun sequence K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 Q5FW38 243 2.9e-19 Nuclear factor interleukin-3-regulated protein OS=Xenopus tropicalis GN=nfil3 PE=2 SV=1 PF00170//PF07716//PF03131 bZIP transcription factor//Basic region leucine zipper//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.42125 BF_2 19.52 0.76 1368 642910507 XP_008200244.1 1392 3.4e-151 PREDICTED: uncharacterized protein LOC660017 [Tribolium castaneum] 462373318 APGK01024789.1 75 1.241e-28 Dendroctonus ponderosae Seq01024799, whole genome shotgun sequence K12114 VRI vrille http://www.genome.jp/dbget-bin/www_bget?ko:K12114 Q5FW38 243 2.4e-19 Nuclear factor interleukin-3-regulated protein OS=Xenopus tropicalis GN=nfil3 PE=2 SV=1 PF07716//PF00170//PF03131 Basic region leucine zipper//bZIP transcription factor//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3119 Basic region leucine zipper transcription factor Cluster-8309.42127 BF_2 584.70 3.04 8341 642929719 XP_008195949.1 2566 1.5e-286 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.89609e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q28653 2003 1.2e-222 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Oryctolagus cuniculus GN=PPP2R5D PE=2 SV=1 PF00910//PF00515//PF00004//PF01695//PF07728//PF05496//PF01603//PF06068 RNA helicase//Tetratricopeptide repeat//ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//TIP49 C-terminus GO:0006310//GO:0007165//GO:0006281 DNA recombination//signal transduction//DNA repair GO:0016887//GO:0009378//GO:0003724//GO:0008601//GO:0005524//GO:0003678//GO:0003723//GO:0005515 ATPase activity//four-way junction helicase activity//RNA helicase activity//protein phosphatase type 2A regulator activity//ATP binding//DNA helicase activity//RNA binding//protein binding GO:0000159//GO:0009379//GO:0005657 protein phosphatase type 2A complex//Holliday junction helicase complex//replication fork KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.42128 BF_2 175.99 0.82 9301 642915919 XP_008190810.1 5279 0.0e+00 PREDICTED: protein retinal degeneration B isoform X2 [Tribolium castaneum] 642915918 XM_008192588.1 895 0 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X4, mRNA -- -- -- -- P43125 3845 0.0e+00 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF16656//PF02480//PF00041//PF13895//PF03767//PF02121//PF02862 Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Fibronectin type III domain//Immunoglobulin domain//HAD superfamily, subfamily IIIB (Acid phosphatase)//Phosphatidylinositol transfer protein//DDHD domain GO:0006771//GO:0019497//GO:0006810 riboflavin metabolic process//hexachlorocyclohexane metabolic process//transport GO:0046872//GO:0003993//GO:0005515 metal ion binding//acid phosphatase activity//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.42129 BF_2 316.19 1.49 9171 642915923 XP_008190812.1 5097 0.0e+00 PREDICTED: protein retinal degeneration B isoform X4 [Tribolium castaneum] 642915922 XM_008192590.1 835 0 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X6, mRNA -- -- -- -- P43125 3461 0.0e+00 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF13895//PF03767//PF00041//PF16656//PF02480//PF02862//PF02121 Immunoglobulin domain//HAD superfamily, subfamily IIIB (Acid phosphatase)//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//DDHD domain//Phosphatidylinositol transfer protein GO:0006771//GO:0019497//GO:0006810 riboflavin metabolic process//hexachlorocyclohexane metabolic process//transport GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.42130 BF_2 57.28 0.57 4499 91094823 XP_971065.1 3140 0.0e+00 PREDICTED: protein O-mannosyltransferase 1 [Tribolium castaneum] 847169839 XM_002938748.3 97 2.44736e-40 PREDICTED: Xenopus (Silurana) tropicalis proteasome (prosome, macropain) subunit, beta type, 7 (psmb7), mRNA K00728 POMT dolichyl-phosphate-mannose-protein mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00728 Q9VTK2 2264 3.6e-253 Protein O-mannosyltransferase 1 OS=Drosophila melanogaster GN=rt PE=2 SV=2 PF02815//PF02366//PF00227 MIR domain//Dolichyl-phosphate-mannose-protein mannosyltransferase//Proteasome subunit GO:0006493//GO:0051603 protein O-linked glycosylation//proteolysis involved in cellular protein catabolic process GO:0000030//GO:0004298 mannosyltransferase activity//threonine-type endopeptidase activity GO:0016020//GO:0005839//GO:0000136 membrane//proteasome core complex//alpha-1,6-mannosyltransferase complex KOG3359 Dolichyl-phosphate-mannose:protein O-mannosyl transferase Cluster-8309.42132 BF_2 1912.16 13.17 6362 189239475 XP_975363.2 2302 4.8e-256 PREDICTED: atlastin [Tribolium castaneum]>gi|270010557|gb|EFA07005.1| hypothetical protein TcasGA2_TC009975 [Tribolium castaneum] 462343538 APGK01035351.1 39 6.05366e-08 Dendroctonus ponderosae Seq01035361, whole genome shotgun sequence K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 1767 2.2e-195 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 PF13176//PF02263//PF13414//PF00515//PF00106//PF02841//PF13174//PF00056//PF12242//PF02882//PF13181//PF07475//PF01370 Tetratricopeptide repeat//Guanylate-binding protein, N-terminal domain//TPR repeat//Tetratricopeptide repeat//short chain dehydrogenase//Guanylate-binding protein, C-terminal domain//Tetratricopeptide repeat//lactate/malate dehydrogenase, NAD binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetratricopeptide repeat//HPr Serine kinase C-terminal domain//NAD dependent epimerase/dehydratase family GO:0000160//GO:0046487//GO:0006109//GO:0009396//GO:0055114//GO:0008152//GO:0016310//GO:0006184 phosphorelay signal transduction system//glyoxylate metabolic process//regulation of carbohydrate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process//metabolic process//phosphorylation//obsolete GTP catabolic process GO:0000155//GO:0005524//GO:0050662//GO:0003924//GO:0004488//GO:0003824//GO:0005515//GO:0016491//GO:0005525//GO:0004672 phosphorelay sensor kinase activity//ATP binding//coenzyme binding//GTPase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//protein binding//oxidoreductase activity//GTP binding//protein kinase activity GO:0009365 protein histidine kinase complex KOG2037 Guanylate-binding protein Cluster-8309.42133 BF_2 847.72 5.91 6283 189239475 XP_975363.2 2302 4.8e-256 PREDICTED: atlastin [Tribolium castaneum]>gi|270010557|gb|EFA07005.1| hypothetical protein TcasGA2_TC009975 [Tribolium castaneum] 462343538 APGK01035351.1 39 5.97805e-08 Dendroctonus ponderosae Seq01035361, whole genome shotgun sequence K17339 ATL atlastin http://www.genome.jp/dbget-bin/www_bget?ko:K17339 Q9VC57 1767 2.1e-195 Atlastin OS=Drosophila melanogaster GN=atl PE=1 SV=1 PF13414//PF02263//PF13174//PF13176//PF02841//PF00515//PF13181 TPR repeat//Guanylate-binding protein, N-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat//Guanylate-binding protein, C-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006184 obsolete GTP catabolic process GO:0005515//GO:0003924//GO:0005525 protein binding//GTPase activity//GTP binding -- -- KOG2037 Guanylate-binding protein Cluster-8309.42134 BF_2 749.07 17.47 2081 189235662 XP_001811794.1 1463 3.1e-159 PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum]>gi|642917553|ref|XP_008191254.1| PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42135 BF_2 53.29 0.49 4807 91092640 XP_969145.1 2864 0.0e+00 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K19415 PHF8, JHDM1F lysine-specific demethylase PHF8 http://www.genome.jp/dbget-bin/www_bget?ko:K19415 P0CF52 1246 4.2e-135 Lysine-specific demethylase 7B OS=Danio rerio GN=jhdm1db PE=2 SV=1 PF00628 PHD-finger -- -- GO:0043169//GO:0005515 cation binding//protein binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.42136 BF_2 19.41 0.48 1984 478252606 ENN73011.1 995 5.4e-105 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 755890983 XM_005189166.2 182 5.99488e-88 PREDICTED: Musca domestica cdc42 homolog (LOC101898849), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q17031 953 1.7e-101 Cdc42 homolog OS=Anopheles gambiae GN=Cdc42 PE=2 SV=2 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.42139 BF_2 18.00 3.82 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42140 BF_2 294.98 3.66 3655 390362249 XP_001190749.2 463 4.9e-43 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q9ERK0 350 2.5e-31 Receptor-interacting serine/threonine-protein kinase 4 OS=Mus musculus GN=Ripk4 PE=1 SV=2 PF00931//PF13606//PF00023 NB-ARC domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0043531//GO:0005515 ADP binding//protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.42141 BF_2 62.02 0.79 3586 390362249 XP_001190749.2 463 4.8e-43 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K08848 RIPK4 receptor-interacting serine/threonine-protein kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08848 Q9ERK0 350 2.5e-31 Receptor-interacting serine/threonine-protein kinase 4 OS=Mus musculus GN=Ripk4 PE=1 SV=2 PF00931//PF13606//PF00023 NB-ARC domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0043531//GO:0005515 ADP binding//protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.42142 BF_2 109.02 1.18 4161 642930410 XP_008196388.1 3749 0.0e+00 PREDICTED: presequence protease, mitochondrial [Tribolium castaneum]>gi|270010721|gb|EFA07169.1| hypothetical protein TcasGA2_TC010168 [Tribolium castaneum] -- -- -- -- -- K06972 K06972 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06972 Q9V9E3 2309 2.0e-258 Presequence protease, mitochondrial OS=Drosophila melanogaster GN=CG3107 PE=2 SV=2 PF08397//PF08367 IRSp53/MIM homology domain//Peptidase M16C associated GO:0007009//GO:0006508 plasma membrane organization//proteolysis GO:0046872//GO:0008270//GO:0004222 metal ion binding//zinc ion binding//metalloendopeptidase activity -- -- KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.42144 BF_2 871.30 27.98 1590 189239803 XP_970743.2 1019 7.1e-108 PREDICTED: TRAF-type zinc finger domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R970 128 6.1e-06 TRAF-type zinc finger domain-containing protein 1 OS=Macaca fascicularis GN=TRAFD1 PE=2 SV=1 PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.42145 BF_2 311.00 6.94 2161 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01293 Phosphoenolpyruvate carboxykinase GO:0006094//GO:0015976//GO:0006099 gluconeogenesis//carbon utilization//tricarboxylic acid cycle GO:0004612//GO:0005524 phosphoenolpyruvate carboxykinase (ATP) activity//ATP binding -- -- -- -- Cluster-8309.42146 BF_2 22.00 112.79 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42147 BF_2 301.14 2.71 4933 642923556 XP_008193558.1 1060 3.9e-112 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270006985|gb|EFA03433.1| hypothetical protein TcasGA2_TC013423 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH60 226 8.2e-17 Golgi-associated PDZ and coiled-coil motif-containing protein OS=Mus musculus GN=Gopc PE=1 SV=1 PF07464 Apolipophorin-III precursor (apoLp-III) GO:0006869 lipid transport GO:0008289 lipid binding GO:0005576 extracellular region -- -- Cluster-8309.42150 BF_2 232.00 3.17 3344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42154 BF_2 668.79 16.31 2002 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42155 BF_2 789.21 19.13 2013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42156 BF_2 9.70 0.48 1129 642920003 XP_008192163.1 1051 9.9e-112 PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum]>gi|642920005|ref|XP_008192164.1| PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K16059 STIM1 stromal interaction molecule 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16059 P83094 706 4.1e-73 Stromal interaction molecule homolog OS=Drosophila melanogaster GN=Stim PE=1 SV=1 PF05384//PF10473//PF07851//PF15291//PF01576//PF00769//PF01940 Sensor protein DegS//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TMPIT-like protein//Dermcidin, antibiotic peptide//Myosin tail//Ezrin/radixin/moesin family//Integral membrane protein DUF92 GO:0031640//GO:0007165 killing of cells of other organism//signal transduction GO:0008233//GO:0016301//GO:0045502//GO:0008134//GO:0003774//GO:0042803//GO:0008092 peptidase activity//kinase activity//dynein binding//transcription factor binding//motor activity//protein homodimerization activity//cytoskeletal protein binding GO:0005737//GO:0016459//GO:0016021//GO:0019898//GO:0005576//GO:0005667//GO:0030286 cytoplasm//myosin complex//integral component of membrane//extrinsic component of membrane//extracellular region//transcription factor complex//dynein complex -- -- Cluster-8309.42157 BF_2 99.88 1.04 4290 642920003 XP_008192163.1 334 5.2e-28 PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum]>gi|642920005|ref|XP_008192164.1| PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42160 BF_2 71.73 0.48 6530 91084043 XP_967085.1 1345 4.6e-145 PREDICTED: fumarate hydratase, mitochondrial [Tribolium castaneum]>gi|270006696|gb|EFA03144.1| hypothetical protein TcasGA2_TC013056 [Tribolium castaneum] 768408689 XM_011550436.1 157 1.57603e-73 PREDICTED: Plutella xylostella fumarate hydratase, mitochondrial-like (LOC105380827), mRNA K01679 E4.2.1.2B, fumC fumarate hydratase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K01679 Q60HF9 1123 1.1e-120 Fumarate hydratase, mitochondrial OS=Macaca fascicularis GN=FH PE=2 SV=1 PF01336//PF10415//PF01607//PF01029//PF00491 OB-fold nucleic acid binding domain//Fumarase C C-terminus//Chitin binding Peritrophin-A domain//NusB family//Arginase family GO:0019643//GO:0006030//GO:0006106//GO:0006355//GO:0006099 reductive tricarboxylic acid cycle//chitin metabolic process//fumarate metabolic process//regulation of transcription, DNA-templated//tricarboxylic acid cycle GO:0003723//GO:0046872//GO:0016829//GO:0004333//GO:0008061//GO:0003676 RNA binding//metal ion binding//lyase activity//fumarate hydratase activity//chitin binding//nucleic acid binding GO:0045239//GO:0005576 tricarboxylic acid cycle enzyme complex//extracellular region KOG1317 Fumarase Cluster-8309.42162 BF_2 3929.97 41.31 4267 91090308 XP_972041.1 1907 2.1e-210 PREDICTED: mitochondrial enolase superfamily member 1 [Tribolium castaneum]>gi|270013803|gb|EFA10251.1| hypothetical protein TcasGA2_TC012451 [Tribolium castaneum] 27633565 BX060284.1 95 3.00129e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC40CD04 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K18334 fucD L-fuconate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K18334 Q6INX4 1346 9.5e-147 Mitochondrial enolase superfamily member 1 OS=Xenopus laevis GN=enosf1 PE=2 SV=1 PF08116 PhTx neurotoxin family GO:0009405//GO:0009063 pathogenesis//cellular amino acid catabolic process GO:0003824 catalytic activity GO:0005576 extracellular region -- -- Cluster-8309.42163 BF_2 2240.42 57.33 1922 642913828 XP_008201177.1 974 1.4e-102 PREDICTED: microtubule-associated protein tau isoform X3 [Tribolium castaneum] -- -- -- -- -- K04380 MAPT, TAU microtubule-associated protein tau http://www.genome.jp/dbget-bin/www_bget?ko:K04380 P15146 324 1.4e-28 Microtubule-associated protein 2 OS=Rattus norvegicus GN=Map2 PE=1 SV=3 PF00418 Tau and MAP protein, tubulin-binding repeat -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex KOG2418 Microtubule-associated protein TAU Cluster-8309.42166 BF_2 419.33 10.77 1916 189235302 XP_001816128.1 402 3.0e-36 PREDICTED: H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270003676|gb|EFA00124.1| hypothetical protein TcasGA2_TC002940 [Tribolium castaneum] 766934267 XM_011501142.1 68 1.36335e-24 PREDICTED: Ceratosolen solmsi marchali probable H/ACA ribonucleoprotein complex subunit 1 (LOC105363452), mRNA K11128 GAR1, NOLA1 H/ACA ribonucleoprotein complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11128 Q7KVQ0 330 2.8e-29 Probable H/ACA ribonucleoprotein complex subunit 1 OS=Drosophila melanogaster GN=CG4038 PE=1 SV=1 PF04410 Gar1/Naf1 RNA binding region GO:0042254//GO:0001522//GO:0031120 ribosome biogenesis//pseudouridine synthesis//snRNA pseudouridine synthesis GO:0030515//GO:0009982 snoRNA binding//pseudouridine synthase activity GO:0031429 box H/ACA snoRNP complex KOG3262 H/ACA small nucleolar RNP component GAR1 Cluster-8309.42169 BF_2 176.53 17.59 707 642919300 XP_008191816.1 643 1.3e-64 PREDICTED: UDP-glucuronosyltransferase 1-7C-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64638 414 1.9e-39 UDP-glucuronosyltransferase 1-5 OS=Rattus norvegicus GN=Ugt1a5 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.42174 BF_2 917.91 21.49 2074 270008737 EFA05185.1 259 1.2e-19 hypothetical protein TcasGA2_TC015315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.42175 BF_2 772.12 17.51 2132 189238116 XP_001814107.1 259 1.3e-19 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.42177 BF_2 75.46 0.77 4410 642931483 XP_008196604.1 1691 2.4e-185 PREDICTED: insulin receptor substrate 1 isoform X8 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 5.6e-49 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.42178 BF_2 108.00 12.42 651 665805381 XP_008550881.1 412 7.1e-38 PREDICTED: ER lumen protein-retaining receptor [Microplitis demolitor] -- -- -- -- -- K10949 KDELR ER lumen protein retaining receptor http://www.genome.jp/dbget-bin/www_bget?ko:K10949 O76767 400 7.2e-38 ER lumen protein-retaining receptor OS=Drosophila melanogaster GN=KdelR PE=2 SV=1 PF00810 ER lumen protein retaining receptor GO:0006621 protein retention in ER lumen GO:0046923 ER retention sequence binding GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG3106 ER lumen protein retaining receptor Cluster-8309.42179 BF_2 555.98 6.53 3848 642922155 XP_008193037.1 4305 0.0e+00 PREDICTED: afadin isoform X2 [Tribolium castaneum] -- -- -- -- -- K05702 AF6, MLLT4 afadin http://www.genome.jp/dbget-bin/www_bget?ko:K05702 Q9QZQ1 1389 8.9e-152 Afadin OS=Mus musculus GN=Mllt4 PE=1 SV=3 PF13180//PF00595//PF00498//PF16011 PDZ domain//PDZ domain (Also known as DHR or GLGF)//FHA domain//Carbohydrate-binding family 9 GO:0005975//GO:0016052 carbohydrate metabolic process//carbohydrate catabolic process GO:0004553//GO:0030246//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding//protein binding -- -- KOG1892 Actin filament-binding protein Afadin Cluster-8309.42180 BF_2 511.73 1.94 11296 642919281 XP_008191807.1 1507 1.3e-163 PREDICTED: coiled-coil domain-containing protein 85C [Tribolium castaneum] 332376520 BT128443.1 148 2.75227e-68 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 3.6e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF01907//PF08675//PF07503//PF00992//PF07776//PF13465//PF05443//PF05130//PF02892//PF16622//PF00646//PF03836//PF03462//PF00170//PF06495//PF00096//PF06005//PF02922//PF06156//PF00098//PF12937//PF00076//PF06621//PF04739//PF13912//PF00320 Ribosomal protein L37e//RNA binding domain//HypF finger//Troponin//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//FlgN protein//BED zinc finger//zinc-finger C2H2-type//F-box domain//RasGAP C-terminus//PCRF domain//bZIP transcription factor//Fruit fly transformer protein//Zinc finger, C2H2 type//Protein of unknown function (DUF904)//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//Protein of unknown function (DUF972)//Zinc knuckle//F-box-like//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Single-minded protein C-terminus//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//GATA zinc finger GO:0007264//GO:0042254//GO:0005975//GO:0006260//GO:0006415//GO:0006412//GO:0006449//GO:0006397//GO:0006402//GO:0043093//GO:0000917//GO:0044780//GO:0046660//GO:0051252//GO:0006355 small GTPase mediated signal transduction//ribosome biogenesis//carbohydrate metabolic process//DNA replication//translational termination//translation//regulation of translational termination//mRNA processing//mRNA catabolic process//FtsZ-dependent cytokinesis//barrier septum assembly//bacterial-type flagellum assembly//female sex differentiation//regulation of RNA metabolic process//regulation of transcription, DNA-templated GO:0046872//GO:0003676//GO:0003700//GO:0003735//GO:0005515//GO:0016149//GO:0003723//GO:0003677//GO:0004553//GO:0005096//GO:0008270//GO:0043565//GO:0004535 metal ion binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//protein binding//translation release factor activity, codon specific//RNA binding//DNA binding//hydrolase activity, hydrolyzing O-glycosyl compounds//GTPase activator activity//zinc ion binding//sequence-specific DNA binding//poly(A)-specific ribonuclease activity GO:0005667//GO:0005861//GO:0018444//GO:0005634//GO:0005737//GO:0005840//GO:0005622 transcription factor complex//troponin complex//translation release factor complex//nucleus//cytoplasm//ribosome//intracellular KOG1616 Protein involved in Snf1 protein kinase complex assembly Cluster-8309.42181 BF_2 116.41 3.06 1876 642932644 XP_008196931.1 2374 6.4e-265 PREDICTED: regulatory-associated protein of mTOR isoform X3 [Tribolium castaneum] 657579724 XM_008295570.1 285 3.13067e-145 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 2028 3.5e-226 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF06384 Beta-catenin-interacting protein ICAT -- -- GO:0008013 beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.42182 BF_2 76.00 4.86 942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42187 BF_2 169.29 69.73 387 531445261 AGT57839.1 166 1.4e-09 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42190 BF_2 149.18 1.95 3492 91087837 XP_967757.1 683 1.4e-68 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 452 3.6e-43 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01073//PF01715//PF03015 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//IPP transferase//Male sterility protein GO:0008210//GO:0008033//GO:0008209//GO:0006694//GO:0055114//GO:0008207 estrogen metabolic process//tRNA processing//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0003824//GO:0050662//GO:0003854//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.42191 BF_2 457.10 5.57 3723 189239121 XP_001815551.1 604 2.2e-59 PREDICTED: lysM and putative peptidoglycan-binding domain-containing protein 2 [Tribolium castaneum]>gi|270010334|gb|EFA06782.1| hypothetical protein TcasGA2_TC009718 [Tribolium castaneum] 766919473 XM_011505860.1 143 5.42608e-66 PREDICTED: Ceratosolen solmsi marchali transcription initiation factor IIA subunit 2 (LOC105367226), mRNA K03123 TFIIA2, GTF2A2, TOA2 transcription initiation factor TFIIA small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03123 P52656 467 7.0e-45 Transcription initiation factor IIA subunit 2 OS=Drosophila melanogaster GN=TfIIA-S PE=1 SV=1 PF02268//PF02751 Transcription initiation factor IIA, gamma subunit, helical domain//Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG3463 Transcription initiation factor IIA, gamma subunit Cluster-8309.42192 BF_2 197.61 2.26 3947 642932847 XP_008197010.1 1457 2.9e-158 PREDICTED: NAD kinase-like isoform X2 [Tribolium castaneum] 751793735 XM_011208255.1 75 3.63992e-28 PREDICTED: Bactrocera dorsalis NAD kinase (LOC105228428), transcript variant X3, mRNA K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 P58058 1070 8.9e-115 NAD kinase OS=Mus musculus GN=Nadk PE=1 SV=2 PF01513//PF00781 ATP-NAD kinase//Diacylglycerol kinase catalytic domain GO:0006741//GO:0008152//GO:0046497//GO:0006769 NADP biosynthetic process//metabolic process//nicotinate nucleotide metabolic process//nicotinamide metabolic process GO:0016301//GO:0003951 kinase activity//NAD+ kinase activity -- -- KOG2178 Predicted sugar kinase Cluster-8309.42197 BF_2 64.00 22.15 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42198 BF_2 429.74 2.39 7816 270005769 EFA02217.1 6674 0.0e+00 hypothetical protein TcasGA2_TC007876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IEK6 2280 8.7e-255 Ectopic P granules protein 5 homolog OS=Aedes aegypti GN=AAEL009648 PE=3 SV=1 PF12422//PF05493 Condensin II non structural maintenance of chromosomes subunit//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0005634 proton-transporting V-type ATPase, V0 domain//nucleus KOG3622 Uncharacterized conserved protein Cluster-8309.42200 BF_2 1394.82 15.56 4037 189235221 XP_967494.2 2057 7.9e-228 PREDICTED: heterogeneous nuclear ribonucleoprotein U-like protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15047 HNRNPUL1, E1BAP5 heterogeneous nuclear ribonucleoprotein U-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15047 Q8VDM6 770 5.6e-80 Heterogeneous nuclear ribonucleoprotein U-like protein 1 OS=Mus musculus GN=Hnrnpul1 PE=1 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.42201 BF_2 539.62 11.32 2282 189240108 XP_972976.2 2104 1.6e-233 PREDICTED: trifunctional purine biosynthetic protein adenosine-3 [Tribolium castaneum]>gi|270011705|gb|EFA08153.1| hypothetical protein TcasGA2_TC005772 [Tribolium castaneum] -- -- -- -- -- K11787 GART phosphoribosylamine--glycine ligase / phosphoribosylglycinamide formyltransferase / phosphoribosylformylglycinamidine cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K11787 P21872 1613 5.6e-178 Trifunctional purine biosynthetic protein adenosine-3 OS=Gallus gallus GN=GART PE=2 SV=1 PF00551 Formyl transferase GO:0006189//GO:0009113//GO:0006144//GO:0046653//GO:0009058//GO:0009256//GO:0032259 'de novo' IMP biosynthetic process//purine nucleobase biosynthetic process//purine nucleobase metabolic process//tetrahydrofolate metabolic process//biosynthetic process//10-formyltetrahydrofolate metabolic process//methylation GO:0005524//GO:0004641//GO:0016742//GO:0004637//GO:0008168//GO:0046872//GO:0004644 ATP binding//phosphoribosylformylglycinamidine cyclo-ligase activity//hydroxymethyl-, formyl- and related transferase activity//phosphoribosylamine-glycine ligase activity//methyltransferase activity//metal ion binding//phosphoribosylglycinamide formyltransferase activity GO:0005737 cytoplasm KOG0237 Glycinamide ribonucleotide synthetase (GARS)/Aminoimidazole ribonucleotide synthetase (AIRS) Cluster-8309.42202 BF_2 1592.00 52.45 1557 674304046 AIL23554.1 485 5.8e-46 microsomal glutathione S-transferase [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q91VS7 259 3.9e-21 Microsomal glutathione S-transferase 1 OS=Mus musculus GN=Mgst1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42205 BF_2 31.43 0.67 2257 642934520 XP_001812516.2 607 6.0e-60 PREDICTED: tetraspanin-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42206 BF_2 763.89 6.54 5174 642936907 XP_008194437.1 2007 6.3e-222 PREDICTED: fasciclin-1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10675 1362 1.6e-148 Fasciclin-1 OS=Schistocerca americana GN=FAS1 PE=1 SV=1 PF04433//PF15427 SWIRM domain//S100P-binding protein -- -- GO:0005515//GO:0048306 protein binding//calcium-dependent protein binding -- -- KOG1437 Fasciclin and related adhesion glycoproteins Cluster-8309.42211 BF_2 2765.63 218.35 817 332372826 AEE61555.1 695 1.4e-70 unknown [Dendroctonus ponderosae]>gi|478261811|gb|ENN80934.1| hypothetical protein YQE_02640, partial [Dendroctonus ponderosae]>gi|546673703|gb|ERL85262.1| hypothetical protein D910_02683 [Dendroctonus ponderosae] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 427 6.7e-41 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF13409//PF02798//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42212 BF_2 354.44 7.52 2258 642930742 XP_008196074.1 1542 2.3e-168 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18120 220 1.9e-16 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.42213 BF_2 71.30 1.29 2592 642930742 XP_008196074.1 1074 4.9e-114 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18120 220 2.1e-16 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.42215 BF_2 174.00 8.56 1137 642923667 XP_008193834.1 1072 3.6e-114 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] 645393647 KF926102.1 54 4.84717e-17 Spodoptera exigua strain Xen-R ABCC3 mRNA, complete cds K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 755 8.6e-79 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF03193//PF07728//PF00005//PF13304//PF01926 NB-ARC domain//Protein of unknown function, DUF258//AAA domain (dynein-related subfamily)//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase -- -- GO:0005524//GO:0005525//GO:0016887//GO:0043531//GO:0003924 ATP binding//GTP binding//ATPase activity//ADP binding//GTPase activity -- -- -- -- Cluster-8309.42217 BF_2 78.00 0.90 3907 642923667 XP_008193834.1 3044 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 989 2.2e-105 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF03193//PF00005//PF13304//PF00664 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.42219 BF_2 163.45 2.11 3534 642933817 XP_008197388.1 1238 6.4e-133 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3ZQL6 454 2.1e-43 MICAL-like protein 1 OS=Rattus norvegicus GN=Micall1 PE=1 SV=1 PF00412//PF00307//PF00288 LIM domain//Calponin homology (CH) domain//GHMP kinases N terminal domain -- -- GO:0005524//GO:0008270//GO:0005515 ATP binding//zinc ion binding//protein binding -- -- -- -- Cluster-8309.42220 BF_2 17.14 0.68 1346 170057076 XP_001864320.1 434 4.1e-40 ATP-dependent RNA helicase WM6 [Culex quinquefasciatus]>gi|167876642|gb|EDS40025.1| ATP-dependent RNA helicase WM6 [Culex quinquefasciatus] 827475656 NM_212977.2 111 1.18646e-48 Danio rerio DEAD (Asp-Glu-Ala-Asp) box polypeptide 39Ab (ddx39ab), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 417 1.6e-39 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- GO:0008026//GO:0005524//GO:0003676 ATP-dependent helicase activity//ATP binding//nucleic acid binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.42221 BF_2 285.82 1.69 7365 642911809 XP_008200752.1 5163 0.0e+00 PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911811|ref|XP_008200753.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911813|ref|XP_008200754.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.42223 BF_2 45.66 1.25 1810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42224 BF_2 273.07 2.11 5689 642923519 XP_008193543.1 1676 1.7e-183 PREDICTED: coiled-coil domain-containing protein 6 isoform X1 [Tribolium castaneum] 817195200 XM_012417714.1 198 2.21697e-96 PREDICTED: Orussus abietinus coiled-coil domain-containing protein 6 (LOC105695793), mRNA K09288 CCDC6, PTC coiled-coil domain-containing protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09288 Q16204 962 4.3e-102 Coiled-coil domain-containing protein 6 OS=Homo sapiens GN=CCDC6 PE=1 SV=2 PF04434//PF04551//PF04647 SWIM zinc finger//GcpE protein//Accessory gene regulator B GO:0016114//GO:0009405//GO:0009372//GO:0055114 terpenoid biosynthetic process//pathogenesis//quorum sensing//oxidation-reduction process GO:0046429//GO:0008233//GO:0008270 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//peptidase activity//zinc ion binding GO:0016021 integral component of membrane KOG2129 Uncharacterized conserved protein H4 Cluster-8309.42225 BF_2 24.74 0.76 1649 642934319 XP_008198599.1 370 1.3e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42227 BF_2 504.00 13.73 1823 270014963 EFA11411.1 527 9.2e-51 hypothetical protein TcasGA2_TC013586 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02187 Growth-Arrest-Specific Protein 2 Domain GO:0007050 cell cycle arrest -- -- -- -- -- -- Cluster-8309.42228 BF_2 245.11 1.75 6135 478251857 ENN72296.1 1154 6.1e-123 hypothetical protein YQE_11039, partial [Dendroctonus ponderosae]>gi|546673558|gb|ERL85133.1| hypothetical protein D910_02555 [Dendroctonus ponderosae] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 Q5ZLN1 818 2.3e-85 Phosphoglycerate mutase 1 OS=Gallus gallus GN=PGAM1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.42229 BF_2 109.55 1.30 3804 835482914 AKM70276.1 219 1.0e-14 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42233 BF_2 15.39 0.54 1477 357624051 EHJ74956.1 866 3.7e-90 hypothetical protein KGM_12920 [Danaus plexippus] 665810279 XM_008555330.1 104 1.016e-44 PREDICTED: Microplitis demolitor zinc finger protein 330 homolog (LOC103575512), transcript variant X2, mRNA -- -- -- -- Q9VAU9 850 1.1e-89 Zinc finger protein 330 homolog OS=Drosophila melanogaster GN=Noa36 PE=1 SV=1 PF06524//PF13912//PF03155 NOA36 protein//C2H2-type zinc finger//ALG6, ALG8 glycosyltransferase family -- -- GO:0046872//GO:0008270//GO:0016758 metal ion binding//zinc ion binding//transferase activity, transferring hexosyl groups GO:0005789//GO:0005634 endoplasmic reticulum membrane//nucleus -- -- Cluster-8309.42234 BF_2 251.61 9.23 1428 646715259 KDR18930.1 1219 4.1e-131 hypothetical protein L798_06668 [Zootermopsis nevadensis] 665810277 XM_008555329.1 236 4.10662e-118 PREDICTED: Microplitis demolitor zinc finger protein 330 homolog (LOC103575512), transcript variant X1, mRNA -- -- -- -- Q9VAU9 1184 1.9e-128 Zinc finger protein 330 homolog OS=Drosophila melanogaster GN=Noa36 PE=1 SV=1 PF13912//PF06524//PF03155 C2H2-type zinc finger//NOA36 protein//ALG6, ALG8 glycosyltransferase family -- -- GO:0016758//GO:0008270//GO:0046872 transferase activity, transferring hexosyl groups//zinc ion binding//metal ion binding GO:0005634//GO:0005789 nucleus//endoplasmic reticulum membrane -- -- Cluster-8309.42235 BF_2 164.04 3.05 2539 91095137 XP_972151.1 803 1.3e-82 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 2.14144e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 639 5.4e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.42238 BF_2 93.87 3.49 1413 642917782 XP_008191284.1 1636 1.8e-179 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [Tribolium castaneum] 170065886 XM_001868022.1 331 6.28889e-171 Culex quinquefasciatus calcium/calmodulin-dependent protein kinase type II alpha chain, mRNA K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 1551 5.3e-171 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.42239 BF_2 1175.28 10.02 5192 270004788 EFA01236.1 630 3.0e-62 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42240 BF_2 378.51 1.35 12018 642929438 XP_008195840.1 3313 0.0e+00 PREDICTED: transient receptor potential cation channel trpm isoform X1 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 2545 2.5e-285 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 PF00312//PF00520//PF16519//PF12122//PF07992 Ribosomal protein S15//Ion transport protein//Tetramerisation domain of TRPM//Cytoplasmic N-terminal domain of rhomboid serine protease//Pyridine nucleotide-disulphide oxidoreductase GO:0051262//GO:0055085//GO:0006412//GO:0055114//GO:0042254//GO:0006811 protein tetramerization//transmembrane transport//translation//oxidation-reduction process//ribosome biogenesis//ion transport GO:0016491//GO:0003735//GO:0005216//GO:0004252 oxidoreductase activity//structural constituent of ribosome//ion channel activity//serine-type endopeptidase activity GO:0016021//GO:0005840//GO:0005622//GO:0016020 integral component of membrane//ribosome//intracellular//membrane KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.42241 BF_2 875.20 35.93 1306 642926079 XP_008194755.1 840 3.3e-87 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 522 1.0e-51 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01370//PF00106//PF12242 NAD dependent epimerase/dehydratase family//short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.42242 BF_2 521.04 7.68 3124 270002093 EEZ98540.1 1018 1.8e-107 hypothetical protein TcasGA2_TC001044 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09297//PF13180//PF00595 NADH pyrophosphatase zinc ribbon domain//PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0046872//GO:0005515//GO:0016787 metal ion binding//protein binding//hydrolase activity -- -- -- -- Cluster-8309.42243 BF_2 1064.77 8.96 5257 270003794 EFA00242.1 2448 4.7e-273 hypothetical protein TcasGA2_TC003070 [Tribolium castaneum] -- -- -- -- -- K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.7e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF00621//PF02454 RhoGEF domain//Sigma 1s protein GO:0035023//GO:0043087//GO:0019048 regulation of Rho protein signal transduction//regulation of GTPase activity//modulation by virus of host morphology or physiology GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.42245 BF_2 279.54 2.18 5654 642920336 XP_008192303.1 1655 4.5e-181 PREDICTED: zinc finger CCCH domain-containing protein 14 isoform X1 [Tribolium castaneum]>gi|270005252|gb|EFA01700.1| hypothetical protein TcasGA2_TC007276 [Tribolium castaneum] 462358939 APGK01029925.1 99 2.38155e-41 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- Q5TYQ8 389 1.2e-35 Zinc finger CCCH domain-containing protein 14 OS=Danio rerio GN=zc3h14 PE=2 SV=1 PF01480//PF03595 PWI domain//Voltage-dependent anion channel GO:0006397//GO:0055085 mRNA processing//transmembrane transport -- -- GO:0016021 integral component of membrane KOG3702 Nuclear polyadenylated RNA binding protein Cluster-8309.42249 BF_2 29.48 0.66 2161 91084897 XP_969410.1 888 1.5e-92 PREDICTED: protein NipSnap [Tribolium castaneum]>gi|270008564|gb|EFA05012.1| hypothetical protein TcasGA2_TC015094 [Tribolium castaneum] 195403178 XM_002060136.1 104 1.49793e-44 Drosophila virilis GJ18493 (Dvir\GJ18493), mRNA -- -- -- -- Q9VXK0 764 1.5e-79 Protein NipSnap OS=Drosophila melanogaster GN=Nipsnap PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2883 NIPSNAP1 protein Cluster-8309.42250 BF_2 152.41 2.83 2544 817065189 XP_012254374.1 297 6.0e-24 PREDICTED: uncharacterized protein LOC105685104 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01576//PF04111 Myosin tail//Autophagy protein Apg6 GO:0006914 autophagy GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.42253 BF_2 96.20 0.49 8475 478258659 ENN78709.1 2012 2.7e-222 hypothetical protein YQE_04881, partial [Dendroctonus ponderosae] 478512620 XM_004430515.1 38 2.90465e-07 PREDICTED: Ceratotherium simum simum death inducer-obliterator 1 (DIDO1), mRNA -- -- -- -- Q8BFT6 638 2.4e-64 JmjC domain-containing protein 4 OS=Mus musculus GN=Jmjd4 PE=2 SV=1 PF07533//PF06427//PF00628//PF07500 BRK domain//UDP-glucose:Glycoprotein Glucosyltransferase//PHD-finger//Transcription factor S-II (TFIIS), central domain GO:0006351//GO:0006486 transcription, DNA-templated//protein glycosylation GO:0003980//GO:0016817//GO:0005515 UDP-glucose:glycoprotein glucosyltransferase activity//hydrolase activity, acting on acid anhydrides//protein binding -- -- KOG2131 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.42254 BF_2 12.00 2.27 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42255 BF_2 7.00 1.63 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42257 BF_2 6.19 0.57 745 817061123 XP_012252151.1 145 7.4e-07 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42259 BF_2 171.85 3.48 2353 817061123 XP_012252151.1 374 6.6e-33 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00448//PF00910//PF00004//PF07757//PF04471 SRP54-type protein, GTPase domain//RNA helicase//ATPase family associated with various cellular activities (AAA)//Predicted AdoMet-dependent methyltransferase//Restriction endonuclease GO:0009307//GO:0006614 DNA restriction-modification system//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0008168//GO:0005525//GO:0004519//GO:0003723//GO:0005524//GO:0003677 RNA helicase activity//methyltransferase activity//GTP binding//endonuclease activity//RNA binding//ATP binding//DNA binding -- -- -- -- Cluster-8309.42260 BF_2 29.00 10.37 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42261 BF_2 3626.32 142.06 1355 607303795 EZA45171.1 539 2.8e-52 lipase 3-like protein-1, partial [Microplitis demolitor] -- -- -- -- -- -- -- -- -- P04634 381 2.4e-35 Gastric triacylglycerol lipase OS=Rattus norvegicus GN=Lipf PE=1 SV=1 PF02129//PF02450//PF04083 X-Pro dipeptidyl-peptidase (S15 family)//Lecithin:cholesterol acyltransferase//Partial alpha/beta-hydrolase lipase region GO:0042967//GO:0006629 acyl-carrier-protein biosynthetic process//lipid metabolic process GO:0008374//GO:0016787 O-acyltransferase activity//hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.42262 BF_2 1855.00 30.94 2795 546672677 ERL84468.1 1435 7.3e-156 hypothetical protein D910_01899 [Dendroctonus ponderosae] 642918939 XM_008193444.1 321 4.55942e-165 PREDICTED: Tribolium castaneum B-box type zinc finger protein ncl-1-like (LOC662730), transcript variant X6, mRNA -- -- -- -- P34611 526 7.6e-52 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.42263 BF_2 883.06 4.12 9253 546681221 ERL91356.1 1694 2.2e-185 hypothetical protein D910_08688 [Dendroctonus ponderosae] 642927571 XM_008197097.1 82 1.10137e-31 PREDICTED: Tribolium castaneum cAMP-dependent protein kinase type II regulatory subunit (LOC661163), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P81900 1231 4.5e-133 cAMP-dependent protein kinase type II regulatory subunit OS=Drosophila melanogaster GN=Pka-R2 PE=1 SV=2 PF00701//PF15494 Dihydrodipicolinate synthetase family//Scavenger receptor cysteine-rich domain GO:0008152 metabolic process GO:0016829 lyase activity GO:0016020 membrane KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.42265 BF_2 430.05 9.65 2151 91091790 XP_970226.1 2606 9.2e-292 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X1 [Tribolium castaneum] 195481875 XM_002101781.1 176 1.40885e-84 Drosophila yakuba GE15405 (Dyak\GE15405), partial mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 1818 8.9e-202 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0005509//GO:0004571 calcium ion binding//mannosyl-oligosaccharide 1,2-alpha-mannosidase activity GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.42266 BF_2 166.80 3.30 2400 189235509 XP_969871.2 1975 1.5e-218 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 721 1.6e-74 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.42270 BF_2 165.62 3.73 2146 645020639 XP_008207241.1 204 3.1e-13 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42271 BF_2 401.00 5.88 3140 642916820 XP_008199515.1 860 3.9e-89 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|642916822|ref|XP_008199516.1| PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270003069|gb|EEZ99516.1| hypothetical protein TcasGA2_TC000097 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6R5N8 333 2.0e-29 Toll-like receptor 13 OS=Mus musculus GN=Tlr13 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.42272 BF_2 650.00 10.17 2962 332376885 AEE63582.1 817 3.5e-84 unknown [Dendroctonus ponderosae] 642921317 XM_966241.2 83 9.7253e-33 PREDICTED: Tribolium castaneum transmembrane protein 165 (LOC659977), mRNA -- -- -- -- P52875 677 2.5e-69 Transmembrane protein 165 OS=Mus musculus GN=Tmem165 PE=2 SV=2 PF01169 Uncharacterized protein family UPF0016 -- -- -- -- GO:0016020 membrane KOG2881 Predicted membrane protein Cluster-8309.42273 BF_2 451.00 51.15 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42274 BF_2 933.00 49.17 1081 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42275 BF_2 119.28 1.09 4846 766923194 XP_011506210.1 2382 1.9e-265 PREDICTED: rab GTPase-activating protein 1-like isoform X1 [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- Q5ZJ17 1531 3.8e-168 Rab GTPase-activating protein 1-like OS=Gallus gallus GN=RABGAP1L PE=2 SV=1 PF07776//PF14719//PF08127//PF00096//PF02892//PF04810//PF01363//PF00640//PF13465 Zinc-finger associated domain (zf-AD)//Phosphotyrosine interaction domain (PTB/PID)//Peptidase family C1 propeptide//Zinc finger, C2H2 type//BED zinc finger//Sec23/Sec24 zinc finger//FYVE zinc finger//Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger double domain GO:0006886//GO:0006888//GO:0050790//GO:0006508 intracellular protein transport//ER to Golgi vesicle-mediated transport//regulation of catalytic activity//proteolysis GO:0005515//GO:0003677//GO:0004197//GO:0046872//GO:0008270 protein binding//DNA binding//cysteine-type endopeptidase activity//metal ion binding//zinc ion binding GO:0005634//GO:0030127 nucleus//COPII vesicle coat -- -- Cluster-8309.42280 BF_2 71.54 4.87 902 242003896 XP_002422903.1 524 1.0e-50 U1 small nuclear ribonucleoprotein 70 kDa, putative [Pediculus humanus corporis]>gi|212505785|gb|EEB10165.1| U1 small nuclear ribonucleoprotein 70 kDa, putative [Pediculus humanus corporis] 766937927 XM_011503139.1 111 7.85791e-49 PREDICTED: Ceratosolen solmsi marchali U1 small nuclear ribonucleoprotein 70 kDa-like (LOC105365059), mRNA K11093 SNRP70 U1 small nuclear ribonucleoprotein 70kDa http://www.genome.jp/dbget-bin/www_bget?ko:K11093 P17133 503 1.1e-49 U1 small nuclear ribonucleoprotein 70 kDa OS=Drosophila melanogaster GN=snRNP-U1-70K PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.42283 BF_2 1424.18 15.43 4148 189241359 XP_971054.2 1182 2.3e-126 PREDICTED: DNA primase small subunit isoform X2 [Tribolium castaneum]>gi|270013128|gb|EFA09576.1| hypothetical protein TcasGA2_TC011690 [Tribolium castaneum] 815822303 XM_012377001.1 72 1.78053e-26 PREDICTED: Linepithema humile DNA primase small subunit (LOC105678028), mRNA K02684 PRI1 DNA primase small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02684 Q24317 930 1.6e-98 DNA primase small subunit OS=Drosophila melanogaster GN=DNApol-alpha50 PE=2 SV=2 PF01896//PF00595//PF13180 Eukaryotic and archaeal DNA primase small subunit//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006260//GO:0006206//GO:0006269//GO:0006351//GO:0006144 DNA replication//pyrimidine nucleobase metabolic process//DNA replication, synthesis of RNA primer//transcription, DNA-templated//purine nucleobase metabolic process GO:0003896//GO:0003899//GO:0005515 DNA primase activity//DNA-directed RNA polymerase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2851 Eukaryotic-type DNA primase, catalytic (small) subunit Cluster-8309.42286 BF_2 983.57 6.03 7113 91092226 XP_970548.1 8921 0.0e+00 PREDICTED: plexin-A2 [Tribolium castaneum]>gi|642912031|ref|XP_008199067.1| PREDICTED: plexin-A2 [Tribolium castaneum]>gi|270015104|gb|EFA11552.1| plexin A [Tribolium castaneum] 665792256 XM_008545501.1 519 0 PREDICTED: Microplitis demolitor plexin-A4 (LOC103568572), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 P70207 3582 0.0e+00 Plexin-A2 OS=Mus musculus GN=Plxna2 PE=1 SV=2 PF01833//PF01437//PF01403 IPT/TIG domain//Plexin repeat//Sema domain GO:0007165//GO:0007275 signal transduction//multicellular organismal development GO:0005515//GO:0004872 protein binding//receptor activity GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.42287 BF_2 245.26 1.54 6939 91092226 XP_970548.1 8921 0.0e+00 PREDICTED: plexin-A2 [Tribolium castaneum]>gi|642912031|ref|XP_008199067.1| PREDICTED: plexin-A2 [Tribolium castaneum]>gi|270015104|gb|EFA11552.1| plexin A [Tribolium castaneum] 665792256 XM_008545501.1 519 0 PREDICTED: Microplitis demolitor plexin-A4 (LOC103568572), transcript variant X2, mRNA K06820 PLXNA plexin A http://www.genome.jp/dbget-bin/www_bget?ko:K06820 P70207 3582 0.0e+00 Plexin-A2 OS=Mus musculus GN=Plxna2 PE=1 SV=2 PF01833//PF01403//PF01437 IPT/TIG domain//Sema domain//Plexin repeat GO:0007275//GO:0007165 multicellular organismal development//signal transduction GO:0005515//GO:0004872 protein binding//receptor activity GO:0016020//GO:0005622//GO:0016021 membrane//intracellular//integral component of membrane KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.42288 BF_2 8.01 0.38 1180 642920232 XP_008192259.1 148 5.3e-07 PREDICTED: uncharacterized protein LOC103312697 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03366//PF09003 YEATS family//Bacteriophage lambda integrase, N-terminal domain GO:0015074//GO:0006355 DNA integration//regulation of transcription, DNA-templated GO:0008907//GO:0003677 integrase activity//DNA binding -- -- -- -- Cluster-8309.42289 BF_2 257.31 2.79 4141 270006069 EFA02517.1 2899 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 199 4.47608e-97 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 P45481 798 3.2e-83 CREB-binding protein OS=Mus musculus GN=Crebbp PE=1 SV=3 PF02135//PF00439//PF02172//PF16987//PF12437 TAZ zinc finger//Bromodomain//KIX domain//KIX domain//Glutamine synthetase type III N terminal GO:0042967//GO:0006807//GO:0009252//GO:0006355 acyl-carrier-protein biosynthetic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process//regulation of transcription, DNA-templated GO:0005515//GO:0004402//GO:0004356//GO:0008270//GO:0003712 protein binding//histone acetyltransferase activity//glutamate-ammonia ligase activity//zinc ion binding//transcription cofactor activity GO:0005667//GO:0005634//GO:0000123 transcription factor complex//nucleus//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.4229 BF_2 7.00 0.61 770 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42290 BF_2 1833.37 8.80 9006 270006069 EFA02517.1 3497 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 703 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2346 2.2e-262 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF00439//PF07711//PF12437//PF00569//PF09468//PF16987//PF02172//PF09030//PF02135//PF08214 Bromodomain//Rab geranylgeranyl transferase alpha-subunit, insert domain//Glutamine synthetase type III N terminal//Zinc finger, ZZ type//Ydr279p protein family (RNase H2 complex component)//KIX domain//KIX domain//Creb binding//TAZ zinc finger//Histone acetylation protein GO:0016573//GO:0042967//GO:0006355//GO:0009252//GO:0006807 histone acetylation//acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated//peptidoglycan biosynthetic process//nitrogen compound metabolic process GO:0008270//GO:0003712//GO:0004663//GO:0004356//GO:0005515//GO:0003713//GO:0004402 zinc ion binding//transcription cofactor activity//Rab geranylgeranyltransferase activity//glutamate-ammonia ligase activity//protein binding//transcription coactivator activity//histone acetyltransferase activity GO:0005634//GO:0005968//GO:0005667//GO:0000123 nucleus//Rab-protein geranylgeranyltransferase complex//transcription factor complex//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.42292 BF_2 271.03 2.03 5859 91088115 XP_969791.1 1930 6.1e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 5.8e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF01105//PF04851 DEAD/DEAH box helicase//emp24/gp25L/p24 family/GOLD//Type III restriction enzyme, res subunit GO:0006810 transport GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0008026 ATP binding//DNA binding//hydrolase activity//nucleic acid binding//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.42294 BF_2 67.04 0.66 4516 91088115 XP_969791.1 1930 4.7e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 4.5e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF01105//PF04851 DEAD/DEAH box helicase//emp24/gp25L/p24 family/GOLD//Type III restriction enzyme, res subunit GO:0006810 transport GO:0003677//GO:0016787//GO:0003676//GO:0005524//GO:0008026 DNA binding//hydrolase activity//nucleic acid binding//ATP binding//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.42295 BF_2 85.70 1.15 3396 546682278 ERL92239.1 2053 1.9e-227 hypothetical protein D910_09556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 245 3.5e-19 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF00452 Apoptosis regulator proteins, Bcl-2 family GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.42296 BF_2 94.41 1.56 2821 478252683 ENN73079.1 193 7.6e-12 hypothetical protein YQE_10283, partial [Dendroctonus ponderosae]>gi|546682842|gb|ERL92731.1| hypothetical protein D910_10041 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42297 BF_2 386.41 21.73 1031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03402 Vomeronasal organ pheromone receptor family, V1R GO:0007186//GO:0007606//GO:0019236 G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//response to pheromone GO:0016503 pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.42298 BF_2 1717.90 9.88 7563 270013391 EFA09839.1 9941 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07008 594 2.7e-59 Neurogenic locus notch homolog protein 1 OS=Rattus norvegicus GN=Notch1 PE=1 SV=3 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.42300 BF_2 102.21 2.59 1935 189238895 XP_966473.2 663 1.7e-66 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 9.0e-28 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF00128//PF13855 Alpha amylase, catalytic domain//Leucine rich repeat GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169//GO:0005515 catalytic activity//cation binding//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.42301 BF_2 264.39 4.40 2800 478257550 ENN77704.1 2497 5.2e-279 hypothetical protein YQE_05776, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VUY0 1367 2.3e-149 MOXD1 homolog 1 OS=Drosophila melanogaster GN=CG5235 PE=2 SV=2 PF07465//PF01082 Photosystem I protein M (PsaM)//Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0055114//GO:0015979 oxidation-reduction process//photosynthesis GO:0016715//GO:0004497//GO:0005507 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-8309.42302 BF_2 1313.33 5.65 10009 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.5e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF00168//PF02891//PF00397//PF05430//PF01155//PF00632 C2 domain//MIZ/SP-RING zinc finger//WW domain//S-adenosyl-L-methionine-dependent methyltransferase//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//HECT-domain (ubiquitin-transferase) GO:0006464//GO:0016567//GO:0055114 cellular protein modification process//protein ubiquitination//oxidation-reduction process GO:0004842//GO:0016151//GO:0005515//GO:0008270//GO:0016645 ubiquitin-protein transferase activity//nickel cation binding//protein binding//zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.42303 BF_2 71.80 0.71 4529 642922287 XP_008193094.1 1398 2.3e-151 PREDICTED: calcium uptake protein 1 homolog, mitochondrial isoform X2 [Tribolium castaneum] 827547479 XM_004926405.2 135 1.8515e-61 PREDICTED: Bombyx mori calcium uptake protein 1 homolog, mitochondrial-like (LOC101741664), mRNA -- -- -- -- A2VEI2 1235 7.5e-134 Calcium uptake protein 1 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4495 PE=2 SV=1 PF13202//PF00036//PF03854//PF12763//PF10591//PF13405//PF13833//PF13499 EF hand//EF hand//P-11 zinc finger//Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF-hand domain pair GO:0007165 signal transduction GO:0005509//GO:0003723//GO:0008270//GO:0005515 calcium ion binding//RNA binding//zinc ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG2643 Ca2+ binding protein, contains EF-hand motifs Cluster-8309.42304 BF_2 447.69 4.11 4845 642914654 XP_008190301.1 1713 7.3e-188 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 9.89596e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 4.4e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42305 BF_2 516.85 7.49 3175 91088951 XP_973830.1 1515 4.4e-165 PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|642932526|ref|XP_008197151.1| PREDICTED: short-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270011559|gb|EFA08007.1| hypothetical protein TcasGA2_TC005596 [Tribolium castaneum] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q07417 1180 1.3e-127 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 PF02771//PF02770//PF00441 Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.42306 BF_2 24.00 12.40 365 -- -- -- -- -- 462329210 APGK01040426.1 36 1.48024e-07 Dendroctonus ponderosae Seq01040436, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.4231 BF_2 23.04 0.94 1310 332374592 AEE62437.1 541 1.6e-52 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 331 1.5e-29 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.42310 BF_2 185.65 1.29 6288 642928263 XP_001812997.2 1813 2.4e-199 PREDICTED: cyclin-T [Tribolium castaneum] -- -- -- -- -- K15188 CCNT cyclin T http://www.genome.jp/dbget-bin/www_bget?ko:K15188 O96433 749 2.4e-77 Cyclin-T OS=Drosophila melanogaster GN=CycT PE=1 SV=2 PF00528//PF03604//PF03526//PF02317 Binding-protein-dependent transport system inner membrane component//DNA directed RNA polymerase, 7 kDa subunit//Colicin E1 (microcin) immunity protein//NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain GO:0055114//GO:0006955//GO:0006206//GO:0030153//GO:0006144//GO:0006810//GO:0006351 oxidation-reduction process//immune response//pyrimidine nucleobase metabolic process//bacteriocin immunity//purine nucleobase metabolic process//transport//transcription, DNA-templated GO:0015643//GO:0016491//GO:0050662//GO:0003899//GO:0003677 toxic substance binding//oxidoreductase activity//coenzyme binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0019814//GO:0016020 nucleolus//immunoglobulin complex//membrane KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.42311 BF_2 100.61 0.64 6901 642928264 XP_969418.2 1644 1.0e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.4e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.42314 BF_2 739.04 4.79 6737 546681938 ERL91934.1 5335 0.0e+00 hypothetical protein D910_09257, partial [Dendroctonus ponderosae] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 O88572 3260 0.0e+00 Low-density lipoprotein receptor-related protein 6 OS=Mus musculus GN=Lrp6 PE=1 SV=1 PF12859//PF00057//PF02244//PF06320 Anaphase-promoting complex subunit 1//Low-density lipoprotein receptor domain class A//Carboxypeptidase activation peptide//GCN5-like protein 1 (GCN5L1) GO:0006508 proteolysis GO:0004180//GO:0005515 carboxypeptidase activity//protein binding GO:0031083//GO:0005680 BLOC-1 complex//anaphase-promoting complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.42316 BF_2 237.54 8.92 1401 189242434 XP_967120.2 498 1.6e-47 PREDICTED: thioredoxin domain-containing protein 17-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DBT3 289 1.2e-24 Thioredoxin domain-containing protein 17 OS=Danio rerio GN=txndc17 PE=2 SV=1 PF13897 Golgi-dynamics membrane-trafficking GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG3425 Uncharacterized conserved protein Cluster-8309.42318 BF_2 1413.15 7.21 8485 91086329 XP_967308.1 2183 4.1e-242 PREDICTED: protein pellino isoform X3 [Tribolium castaneum] 642927955 XM_962215.3 371 0 PREDICTED: Tribolium castaneum protein pellino (LOC662980), transcript variant X3, mRNA K11964 PELI pellino http://www.genome.jp/dbget-bin/www_bget?ko:K11964 O77237 1765 4.9e-195 Protein pellino OS=Drosophila melanogaster GN=Pli PE=1 SV=1 PF14634//PF15723//PF04710//PF05203//PF13897//PF01899//PF13639 zinc-RING finger domain//Motility quorum-sensing regulator, toxin of MqsA//Pellino//Hom_end-associated Hint//Golgi-dynamics membrane-trafficking//Na+/H+ ion antiporter subunit//Ring finger domain GO:0006812//GO:0042710//GO:0017148//GO:0009372//GO:0006810//GO:0030908//GO:0008063 cation transport//biofilm formation//negative regulation of translation//quorum sensing//transport//protein splicing//Toll signaling pathway GO:0008270//GO:0008324//GO:0005515 zinc ion binding//cation transmembrane transporter activity//protein binding GO:0016021 integral component of membrane KOG3842 Adaptor protein Pellino Cluster-8309.42320 BF_2 634.12 2.96 9254 642932362 XP_008197080.1 3162 0.0e+00 PREDICTED: histone acetyltransferase KAT6A isoform X2 [Tribolium castaneum] 688437395 LL190970.1 59 6.7237e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8WML3 1456 3.6e-159 Histone acetyltransferase KAT6B OS=Macaca fascicularis GN=KAT6B PE=2 SV=1 PF00628//PF01853//PF00538//PF13508//PF01160 PHD-finger//MOZ/SAS family//linker histone H1 and H5 family//Acetyltransferase (GNAT) domain//Vertebrate endogenous opioids neuropeptide GO:0007218//GO:0006355//GO:0042967//GO:0006334 neuropeptide signaling pathway//regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process//nucleosome assembly GO:0016747//GO:0005515//GO:0008080//GO:0003677 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//N-acetyltransferase activity//DNA binding GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.42322 BF_2 1285.66 152.85 639 332374452 AEE62367.1 437 8.8e-41 unknown [Dendroctonus ponderosae]>gi|478252607|gb|ENN73012.1| hypothetical protein YQE_10347, partial [Dendroctonus ponderosae]>gi|546677978|gb|ERL88707.1| hypothetical protein D910_06089 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BUZ1 131 1.1e-06 Actin-binding Rho-activating protein OS=Mus musculus GN=Abra PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3376 Uncharacterized conserved protein Cluster-8309.42323 BF_2 326.28 4.07 3640 746838316 XP_011049678.1 1675 1.4e-183 PREDICTED: uncharacterized protein LOC105143221 isoform X1 [Acromyrmex echinatior]>gi|332028468|gb|EGI68511.1| Monocarboxylate transporter 14 [Acromyrmex echinatior] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 447 1.4e-42 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF12537//PF07690//PF00083 The Golgi pH Regulator (GPHR) Family N-terminal//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.42325 BF_2 156.97 3.84 1995 478257528 ENN77683.1 315 3.9e-26 hypothetical protein YQE_05834, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42329 BF_2 240.88 3.05 3596 642925776 XP_008201712.1 1713 5.4e-188 PREDICTED: solute carrier family 26 member 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14453 K14453 solute carrier family 26, other http://www.genome.jp/dbget-bin/www_bget?ko:K14453 Q9BEG8 641 4.5e-65 Sulfate transporter OS=Bos taurus GN=SLC26A2 PE=3 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.42332 BF_2 52.21 0.96 2569 642913828 XP_008201177.1 1006 3.7e-106 PREDICTED: microtubule-associated protein tau isoform X3 [Tribolium castaneum] -- -- -- -- -- K04380 MAPT, TAU microtubule-associated protein tau http://www.genome.jp/dbget-bin/www_bget?ko:K04380 P15146 324 1.8e-28 Microtubule-associated protein 2 OS=Rattus norvegicus GN=Map2 PE=1 SV=3 PF00418 Tau and MAP protein, tubulin-binding repeat -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex KOG2418 Microtubule-associated protein TAU Cluster-8309.42333 BF_2 48.98 0.57 3902 642913824 XP_008201175.1 220 7.8e-15 PREDICTED: microtubule-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00418//PF13912//PF00157 Tau and MAP protein, tubulin-binding repeat//C2H2-type zinc finger//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0015631//GO:0046872 transcription factor activity, sequence-specific DNA binding//tubulin binding//metal ion binding GO:0005667//GO:0045298 transcription factor complex//tubulin complex -- -- Cluster-8309.42334 BF_2 25.67 0.46 2612 642928387 XP_008192723.1 1186 5.1e-127 PREDICTED: dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial [Tribolium castaneum] 852728203 XM_013016081.1 97 1.41359e-40 PREDICTED: Dipodomys ordii dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) (Dlst), mRNA K00658 DLST, sucB 2-oxoglutarate dehydrogenase E2 component (dihydrolipoamide succinyltransferase) http://www.genome.jp/dbget-bin/www_bget?ko:K00658 Q90512 1089 3.7e-117 Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (Fragment) OS=Takifugu rubripes GN=dlst PE=3 SV=1 PF00198 2-oxoacid dehydrogenases acyltransferase (catalytic domain) GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG0559 Dihydrolipoamide succinyltransferase (2-oxoglutarate dehydrogenase, E2 subunit) Cluster-8309.42335 BF_2 79.65 3.62 1207 642912996 XP_008201344.1 703 2.4e-71 PREDICTED: synaptic vesicle glycoprotein 2C-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K06258 SV2 MFS transporter, VNT family, synaptic vesicle glycoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06258 Q9JIS5 276 3.2e-23 Synaptic vesicle glycoprotein 2A OS=Mus musculus GN=Sv2a PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.42336 BF_2 596.47 11.67 2425 642938996 XP_008200109.1 1044 1.4e-110 PREDICTED: serine protease inhibitor 3/4-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 579 4.7e-58 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42338 BF_2 49.12 0.58 3810 642926421 XP_008191955.1 1584 5.2e-173 PREDICTED: TWiK family of potassium channels protein 7 [Tribolium castaneum]>gi|642926423|ref|XP_008191956.1| PREDICTED: TWiK family of potassium channels protein 7 [Tribolium castaneum]>gi|270008467|gb|EFA04915.1| hypothetical protein TcasGA2_TC014979 [Tribolium castaneum] 195131168 XM_002009987.1 121 9.42643e-54 Drosophila mojavensis GI14916 (Dmoj\GI14916), mRNA -- -- -- -- Q9ES08 170 2.0e-10 Potassium channel subfamily K member 9 OS=Rattus norvegicus GN=Kcnk9 PE=1 SV=2 PF12258//PF11857//PF17112//PF00520//PF01007 Microcephalin protein//Domain of unknown function (DUF3377)//Mitochondrial import receptor subunit Tom6, fungal//Ion transport protein//Inward rectifier potassium channel GO:0021987//GO:0055085//GO:0006813//GO:0030150//GO:0006811 cerebral cortex development//transmembrane transport//potassium ion transport//protein import into mitochondrial matrix//ion transport GO:0004222//GO:0005242//GO:0005216 metalloendopeptidase activity//inward rectifier potassium channel activity//ion channel activity GO:0016021//GO:0016020//GO:0008076//GO:0005742 integral component of membrane//membrane//voltage-gated potassium channel complex//mitochondrial outer membrane translocase complex -- -- Cluster-8309.42341 BF_2 2814.46 28.41 4431 642912785 XP_008201251.1 2124 1.5e-235 PREDICTED: uncharacterized protein LOC663557 isoform X1 [Tribolium castaneum] 215277044 NM_001142346.1 412 0 Nasonia vitripennis uncharacterized LOC100119622 (LOC100119622), mRNA -- -- -- -- Q5XIV0 1035 1.1e-110 Protein FAM46C OS=Rattus norvegicus GN=Fam46c PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3852 Uncharacterized conserved protein Cluster-8309.42343 BF_2 182.89 1.15 6966 642922445 XP_008193172.1 5211 0.0e+00 PREDICTED: uncharacterized protein LOC655273 [Tribolium castaneum] 665794170 XM_008546548.1 48 6.585e-13 PREDICTED: Microplitis demolitor adenylate cyclase type 8 (LOC103569316), transcript variant X1, mRNA K08048 ADCY8 adenylate cyclase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08048 P40145 1239 4.0e-134 Adenylate cyclase type 8 OS=Homo sapiens GN=ADCY8 PE=1 SV=1 PF00211//PF06327//PF07701 Adenylate and Guanylate cyclase catalytic domain//Domain of Unknown Function (DUF1053)//Heme NO binding associated GO:0035556//GO:0009190//GO:0006182//GO:0046039//GO:0006171//GO:0006144 intracellular signal transduction//cyclic nucleotide biosynthetic process//cGMP biosynthetic process//GTP metabolic process//cAMP biosynthetic process//purine nucleobase metabolic process GO:0004383//GO:0004016//GO:0016849 guanylate cyclase activity//adenylate cyclase activity//phosphorus-oxygen lyase activity GO:0005886 plasma membrane -- -- Cluster-8309.42344 BF_2 11.53 0.43 1422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08145 BOP1NT (NUC169) domain GO:0006364 rRNA processing -- -- -- -- -- -- Cluster-8309.42345 BF_2 1496.46 27.92 2529 642934118 XP_008199283.1 1895 3.0e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1321 4.5e-144 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0006810//GO:0055085//GO:0003333//GO:0006865 transport//transmembrane transport//amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.42346 BF_2 10.23 0.87 777 91083773 XP_972220.1 220 1.6e-15 PREDICTED: uncharacterized protein LOC660933 [Tribolium castaneum]>gi|270006783|gb|EFA03231.1| hypothetical protein TcasGA2_TC013160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335//PF00328 Tetraspanin family//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.42348 BF_2 304.03 14.46 1167 642919843 XP_008192092.1 1010 5.8e-107 PREDICTED: TIP41-like protein [Tribolium castaneum]>gi|270005393|gb|EFA01841.1| hypothetical protein TcasGA2_TC007443 [Tribolium castaneum] -- -- -- -- -- K17607 TIPRL, TIP41 type 2A phosphatase activator TIP41 http://www.genome.jp/dbget-bin/www_bget?ko:K17607 Q8BH58 544 2.6e-54 TIP41-like protein OS=Mus musculus GN=Tiprl PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3224 Uncharacterized conserved protein Cluster-8309.42349 BF_2 42.00 16.52 392 642918534 XP_008191512.1 190 2.4e-12 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42350 BF_2 11.00 130.19 229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42352 BF_2 257.59 4.28 2806 642937904 XP_008200352.1 2094 2.8e-232 PREDICTED: ankyrin repeat and death domain-containing protein 1A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q495B1 764 1.9e-79 Ankyrin repeat and death domain-containing protein 1A OS=Homo sapiens GN=ANKDD1A PE=2 SV=2 PF00531//PF13606//PF00023 Death domain//Ankyrin repeat//Ankyrin repeat GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.42354 BF_2 177.41 2.14 3752 642937904 XP_008200352.1 1073 9.2e-114 PREDICTED: ankyrin repeat and death domain-containing protein 1A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14DN9 434 4.7e-41 Ankyrin repeat and death domain-containing protein 1B OS=Mus musculus GN=Ankdd1b PE=2 SV=3 PF00023//PF13606//PF00531 Ankyrin repeat//Ankyrin repeat//Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.42355 BF_2 3.00 0.95 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42356 BF_2 60.00 0.45 5880 642912854 XP_008201281.1 2587 4.0e-289 PREDICTED: choline O-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00623 CHAT choline O-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00623 P07668 1668 6.0e-184 Choline O-acetyltransferase OS=Drosophila melanogaster GN=Cha PE=1 SV=3 PF00755 Choline/Carnitine o-acyltransferase -- -- GO:0016746 transferase activity, transferring acyl groups -- -- KOG3717 Carnitine O-acyltransferase CRAT Cluster-8309.42357 BF_2 216.00 13.51 956 91080237 XP_972872.1 762 2.7e-78 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42358 BF_2 1163.14 14.17 3722 642924614 XP_008194364.1 2724 3.3e-305 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.2e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF00554//PF01833 Rel homology DNA-binding domain//IPT/TIG domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005515//GO:0003677 transcription factor activity, sequence-specific DNA binding//protein binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42359 BF_2 178.77 3.28 2569 189239692 XP_967139.2 1433 1.1e-155 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 68 1.83665e-24 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 929 1.3e-98 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF03293//PF01080//PF00957 Poxvirus DNA-directed RNA polymerase, 18 kD subunit//Presenilin//Synaptobrevin GO:0006206//GO:0006351//GO:0019083//GO:0006144//GO:0016192 pyrimidine nucleobase metabolic process//transcription, DNA-templated//viral transcription//purine nucleobase metabolic process//vesicle-mediated transport GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0005730//GO:0016021 nucleolus//integral component of membrane KOG2736 Presenilin Cluster-8309.4236 BF_2 16.00 1.23 833 642915557 XP_008190666.1 518 4.6e-50 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08659 349 7.6e-32 Luciferin 4-monooxygenase OS=Photinus pyralis PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.42360 BF_2 47.34 0.45 4710 478252006 ENN72441.1 2271 1.4e-252 hypothetical protein YQE_10931, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P79098 1174 9.3e-127 Aminopeptidase N OS=Bos taurus GN=ANPEP PE=2 SV=4 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.42362 BF_2 180.09 5.48 1662 282158091 NP_001164089.1 665 8.4e-67 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 P05369 422 5.2e-40 Farnesyl pyrophosphate synthase OS=Rattus norvegicus GN=Fdps PE=2 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.42364 BF_2 4.00 0.45 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42365 BF_2 859.34 5.04 7423 91084647 XP_966816.1 4554 0.0e+00 PREDICTED: carboxypeptidase D [Tribolium castaneum] 332374583 BT127471.1 241 3.61564e-120 Dendroctonus ponderosae clone DPO102_A24 unknown mRNA K07752 CPD carboxypeptidase D http://www.genome.jp/dbget-bin/www_bget?ko:K07752 P42787 2788 0.0e+00 Carboxypeptidase D OS=Drosophila melanogaster GN=svr PE=1 SV=2 PF00036//PF04952//PF01694//PF13202//PF13833//PF10591//PF13405//PF00246//PF13499//PF08038//PF12763 EF hand//Succinylglutamate desuccinylase / Aspartoacylase family//Rhomboid family//EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//Zinc carboxypeptidase//EF-hand domain pair//TOM7 family//Cytoskeletal-regulatory complex EF hand GO:0006508//GO:0007165//GO:0008152//GO:0030150 proteolysis//signal transduction//metabolic process//protein import into mitochondrial matrix GO:0005509//GO:0008270//GO:0004181//GO:0004252//GO:0016788//GO:0005515 calcium ion binding//zinc ion binding//metallocarboxypeptidase activity//serine-type endopeptidase activity//hydrolase activity, acting on ester bonds//protein binding GO:0005578//GO:0005742//GO:0016021 proteinaceous extracellular matrix//mitochondrial outer membrane translocase complex//integral component of membrane KOG2649 Zinc carboxypeptidase Cluster-8309.42366 BF_2 784.00 7.42 4709 642917856 XP_008191315.1 917 1.4e-95 PREDICTED: uncharacterized protein LOC100141538 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.42367 BF_2 320.71 4.81 3079 642913091 XP_008201388.1 2146 2.9e-238 PREDICTED: disks large 1 tumor suppressor protein isoform X10 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.33965e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12075 DLG2_3 discs large protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12075 P31007 1823 3.4e-202 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF14604//PF00595//PF00018 PDZ domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.42370 BF_2 523.75 4.80 4848 642921414 XP_008192856.1 2698 4.4e-302 PREDICTED: N-acetylgalactosaminyltransferase 7 [Tribolium castaneum]>gi|270006291|gb|EFA02739.1| hypothetical protein TcasGA2_TC008465 [Tribolium castaneum] 195447413 XM_002071167.1 186 8.8424e-90 Drosophila willistoni GK25256 (Dwil\GK25256), mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MV48 2294 1.3e-256 N-acetylgalactosaminyltransferase 7 OS=Drosophila melanogaster GN=GalNAc-T2 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.42371 BF_2 16.70 0.53 1602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42373 BF_2 8428.66 86.85 4347 642931522 XP_008196620.1 1438 5.1e-156 PREDICTED: galactokinase-like [Tribolium castaneum]>gi|270011803|gb|EFA08251.1| hypothetical protein TcasGA2_TC005879 [Tribolium castaneum] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 P51570 1029 5.6e-110 Galactokinase OS=Homo sapiens GN=GALK1 PE=1 SV=1 PF00288//PF00640//PF13180//PF00595 GHMP kinases N terminal domain//Phosphotyrosine interaction domain (PTB/PID)//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006012//GO:0046835 galactose metabolic process//carbohydrate phosphorylation GO:0004335//GO:0005515//GO:0005524 galactokinase activity//protein binding//ATP binding GO:0005737 cytoplasm KOG0631 Galactokinase Cluster-8309.42374 BF_2 194.12 0.60 13918 91089729 XP_975072.1 3266 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1876 1.1e-207 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF03328//PF00709//PF13851//PF15036//PF03790//PF07926//PF09726//PF05837//PF08702//PF02183//PF13326//PF04111//PF00654//PF00170//PF05024//PF10473//PF15898//PF15191//PF00769 HpcH/HpaI aldolase/citrate lyase family//Adenylosuccinate synthetase//Growth-arrest specific micro-tubule binding//Interleukin 34//KNOX1 domain//TPR/MLP1/MLP2-like protein//Transmembrane protein//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Photosystem II Pbs27//Autophagy protein Apg6//Voltage gated chloride channel//bZIP transcription factor//N-acetylglucosaminyl transferase component (Gpi1)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//cGMP-dependent protein kinase interacting domain//Synaptonemal complex central element protein 3//Ezrin/radixin/moesin family GO:0001934//GO:0008283//GO:0048870//GO:0006531//GO:0030168//GO:0010207//GO:0055085//GO:0051382//GO:0006164//GO:0006606//GO:0040007//GO:0007130//GO:0006821//GO:0006144//GO:0006506//GO:0006522//GO:0007165//GO:0006914//GO:0051258//GO:0007131//GO:0006355//GO:0008284//GO:0007283 positive regulation of protein phosphorylation//cell proliferation//cell motility//aspartate metabolic process//platelet activation//photosystem II assembly//transmembrane transport//kinetochore assembly//purine nucleotide biosynthetic process//protein import into nucleus//growth//synaptonemal complex assembly//chloride transport//purine nucleobase metabolic process//GPI anchor biosynthetic process//alanine metabolic process//signal transduction//autophagy//protein polymerization//reciprocal meiotic recombination//regulation of transcription, DNA-templated//positive regulation of cell proliferation//spermatogenesis GO:0008092//GO:0004019//GO:0030674//GO:0045502//GO:0008134//GO:0005157//GO:0005102//GO:0003700//GO:0003677//GO:0003824//GO:0017176//GO:0005525//GO:0042803//GO:0019901//GO:0005247//GO:0043565 cytoskeletal protein binding//adenylosuccinate synthase activity//protein binding, bridging//dynein binding//transcription factor binding//macrophage colony-stimulating factor receptor binding//receptor binding//transcription factor activity, sequence-specific DNA binding//DNA binding//catalytic activity//phosphatidylinositol N-acetylglucosaminyltransferase activity//GTP binding//protein homodimerization activity//protein kinase binding//voltage-gated chloride channel activity//sequence-specific DNA binding GO:0030286//GO:0005667//GO:0000776//GO:0019898//GO:0005577//GO:0005615//GO:0005634//GO:0016020//GO:0031514//GO:0016021//GO:0005737 dynein complex//transcription factor complex//kinetochore//extrinsic component of membrane//fibrinogen complex//extracellular space//nucleus//membrane//motile cilium//integral component of membrane//cytoplasm KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.42376 BF_2 489.37 6.36 3506 642933500 XP_008197443.1 2478 1.0e-276 PREDICTED: rho GTPase-activating protein 20-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2F6 386 1.6e-35 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00788//PF00620 Ras association (RalGDS/AF-6) domain//RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.42377 BF_2 138.38 1.28 4814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42379 BF_2 349.58 2.07 7342 260436903 NP_001159498.1 879 5.7e-91 U-box domain containing 5 [Tribolium castaneum] -- -- -- -- -- K10600 UBOX5, UIP5 U-box domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10600 Q925F4 318 2.6e-27 RING finger protein 37 OS=Mus musculus GN=Ubox5 PE=1 SV=2 PF04564//PF14634 U-box domain//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//protein binding -- -- -- -- Cluster-8309.42380 BF_2 215.03 2.01 4769 546683539 ERL93341.1 1541 6.3e-168 hypothetical protein D910_10634 [Dendroctonus ponderosae] -- -- -- -- -- K10641 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 http://www.genome.jp/dbget-bin/www_bget?ko:K10641 Q6UWE0 703 3.9e-72 E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens GN=LRSAM1 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.42381 BF_2 1579.28 14.36 4887 91090894 XP_973482.1 1323 1.2e-142 PREDICTED: ileal sodium/bile acid cotransporter isoform X1 [Tribolium castaneum]>gi|270013229|gb|EFA09677.1| hypothetical protein TcasGA2_TC011805 [Tribolium castaneum] -- -- -- -- -- K14343 SLC10A3_5 solute carrier family 10 (sodium/bile acid cotransporter), member 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14343 P09131 356 6.9e-32 P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1 PF04785//PF01758 Rhabdovirus matrix protein M2//Sodium Bile acid symporter family GO:0016032 viral process -- -- GO:0016020//GO:0019031 membrane//viral envelope KOG2718 Na+-bile acid cotransporter Cluster-8309.42383 BF_2 1550.61 6.89 9697 642916116 XP_008190891.1 1596 5.4e-174 PREDICTED: nuclear pore complex protein Nup153 [Tribolium castaneum] 642916113 XM_008192668.1 546 0 PREDICTED: Tribolium castaneum WW domain-containing adapter protein with coiled-coil (LOC660923), mRNA -- -- -- -- P49790 578 2.5e-57 Nuclear pore complex protein Nup153 OS=Homo sapiens GN=NUP153 PE=1 SV=2 PF03172//PF00397//PF00641//PF03083 Sp100 domain//WW domain//Zn-finger in Ran binding protein and others//Sugar efflux transporter for intercellular exchange -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.42384 BF_2 1038.19 4.67 9593 642916116 XP_008190891.1 1596 5.3e-174 PREDICTED: nuclear pore complex protein Nup153 [Tribolium castaneum] 642916113 XM_008192668.1 379 0 PREDICTED: Tribolium castaneum WW domain-containing adapter protein with coiled-coil (LOC660923), mRNA -- -- -- -- P49790 578 2.4e-57 Nuclear pore complex protein Nup153 OS=Homo sapiens GN=NUP153 PE=1 SV=2 PF03083//PF03172//PF00397//PF00641 Sugar efflux transporter for intercellular exchange//Sp100 domain//WW domain//Zn-finger in Ran binding protein and others -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.42386 BF_2 346.45 7.92 2117 -- -- -- -- -- 642917392 XM_008201450.1 41 1.54141e-09 PREDICTED: Tribolium castaneum ribosomal protein S6 kinase alpha-5 (LOC658616), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42388 BF_2 321.95 3.00 4782 642917393 XP_008199672.1 3544 0.0e+00 PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X2 [Tribolium castaneum] 795078999 XM_012021559.1 166 1.14422e-78 PREDICTED: Vollenhovia emeryi ribosomal protein S6 kinase alpha-5 (LOC105567037), transcript variant X2, mRNA K04445 MSK1, RPS6KA5 ribosomal protein S6 kinase alpha-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04445 O75582 2231 2.6e-249 Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens GN=RPS6KA5 PE=1 SV=1 PF00069//PF06293//PF00433//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.42389 BF_2 51.67 2.11 1313 478250013 ENN70519.1 965 1.1e-101 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 560 4.1e-56 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.42391 BF_2 35.96 0.38 4204 91093150 XP_970085.1 3359 0.0e+00 PREDICTED: ribosomal protein S6 kinase alpha-5 isoform X1 [Tribolium castaneum]>gi|270003008|gb|EEZ99455.1| hypothetical protein TcasGA2_TC000021 [Tribolium castaneum] 795078999 XM_012021559.1 166 1.00487e-78 PREDICTED: Vollenhovia emeryi ribosomal protein S6 kinase alpha-5 (LOC105567037), transcript variant X2, mRNA K04445 MSK1, RPS6KA5 ribosomal protein S6 kinase alpha-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04445 O75582 2214 2.1e-247 Ribosomal protein S6 kinase alpha-5 OS=Homo sapiens GN=RPS6KA5 PE=1 SV=1 PF06293//PF00069//PF07714//PF00433 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Protein kinase C terminal domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.42392 BF_2 1413.38 71.86 1110 332374186 AEE62234.1 1501 6.4e-164 unknown [Dendroctonus ponderosae] 673526012 HG529539.1 38 3.70746e-08 Melanopsichium pennsylvanicum 4 genomic scaffold, scaffold SCAFFOLD72 K03030 PSMD14, RPN11, POH1 26S proteasome regulatory subunit N11 http://www.genome.jp/dbget-bin/www_bget?ko:K03030 Q9V3H2 1448 3.7e-159 26S proteasome non-ATPase regulatory subunit 14 OS=Drosophila melanogaster GN=Rpn11 PE=1 SV=1 PF01398//PF09412 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Endoribonuclease XendoU -- -- GO:0005515//GO:0016788 protein binding//hydrolase activity, acting on ester bonds -- -- KOG1555 26S proteasome regulatory complex, subunit RPN11 Cluster-8309.42393 BF_2 8.62 0.40 1178 332374186 AEE62234.1 1501 6.8e-164 unknown [Dendroctonus ponderosae] 673526012 HG529539.1 38 3.93707e-08 Melanopsichium pennsylvanicum 4 genomic scaffold, scaffold SCAFFOLD72 K03030 PSMD14, RPN11, POH1 26S proteasome regulatory subunit N11 http://www.genome.jp/dbget-bin/www_bget?ko:K03030 Q9V3H2 1448 3.9e-159 26S proteasome non-ATPase regulatory subunit 14 OS=Drosophila melanogaster GN=Rpn11 PE=1 SV=1 PF09412//PF01398 Endoribonuclease XendoU//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515//GO:0016788 protein binding//hydrolase activity, acting on ester bonds -- -- KOG1555 26S proteasome regulatory complex, subunit RPN11 Cluster-8309.42395 BF_2 28.44 0.35 3718 270003898 EFA00346.1 1651 8.7e-181 hypothetical protein TcasGA2_TC003186 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60271 905 1.1e-95 C-Jun-amino-terminal kinase-interacting protein 4 OS=Homo sapiens GN=SPAG9 PE=1 SV=4 PF04508//PF10186//PF01496//PF06156//PF04111//PF01763//PF00458//PF17082//PF02601//PF10473 Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14//V-type ATPase 116kDa subunit family//Protein of unknown function (DUF972)//Autophagy protein Apg6//Herpesvirus UL6 like//WHEP-TRS domain//Spindle Pole Component 29//Exonuclease VII, large subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006914//GO:0006260//GO:0006323//GO:0010508//GO:0015992//GO:0016032//GO:0015991//GO:0030474//GO:0006418//GO:0006308 autophagy//DNA replication//DNA packaging//positive regulation of autophagy//proton transport//viral process//ATP hydrolysis coupled proton transport//spindle pole body duplication//tRNA aminoacylation for protein translation//DNA catabolic process GO:0005524//GO:0008134//GO:0045502//GO:0015078//GO:0005200//GO:0004812//GO:0008855//GO:0042803 ATP binding//transcription factor binding//dynein binding//hydrogen ion transmembrane transporter activity//structural constituent of cytoskeleton//aminoacyl-tRNA ligase activity//exodeoxyribonuclease VII activity//protein homodimerization activity GO:0009318//GO:0005823//GO:0005856//GO:0030286//GO:0005667//GO:0033179 exodeoxyribonuclease VII complex//central plaque of spindle pole body//cytoskeleton//dynein complex//transcription factor complex//proton-transporting V-type ATPase, V0 domain KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.42396 BF_2 569.30 7.68 3390 642939191 XP_008200374.1 647 2.1e-64 PREDICTED: DNA-binding protein P3A2 isoform X5 [Tribolium castaneum] 642939190 XM_008202152.1 172 3.73564e-82 PREDICTED: Tribolium castaneum DNA-binding protein Ewg (LOC658623), transcript variant X7, mRNA K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 267 9.9e-22 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 PF00731 AIR carboxylase GO:0006189 'de novo' IMP biosynthetic process -- -- -- -- -- -- Cluster-8309.42397 BF_2 26.70 0.34 3546 478254065 ENN74357.1 365 1.1e-31 hypothetical protein YQE_09327, partial [Dendroctonus ponderosae] 642939190 XM_008202152.1 91 4.1664e-37 PREDICTED: Tribolium castaneum DNA-binding protein Ewg (LOC658623), transcript variant X7, mRNA K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 155 1.0e-08 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42398 BF_2 69.73 2.16 1636 91085557 XP_966821.1 987 3.8e-104 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 409 1.6e-38 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13414//PF00254//PF13371//PF13181//PF00515 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.42399 BF_2 31.67 0.33 4353 642925954 XP_008195644.1 2047 1.2e-226 PREDICTED: LOW QUALITY PROTEIN: RNA-binding protein 26 [Tribolium castaneum] -- -- -- -- -- K13192 RBM26 RNA-binding protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K13192 Q2T9I5 522 3.4e-51 RNA-binding protein 26 OS=Xenopus laevis GN=rbm26 PE=2 SV=2 PF01429//PF00642//PF00076//PF01480 Methyl-CpG binding domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PWI domain GO:0006397 mRNA processing GO:0003676//GO:0003677//GO:0046872 nucleic acid binding//DNA binding//metal ion binding GO:0005634 nucleus KOG2135 Proteins containing the RNA recognition motif Cluster-8309.42400 BF_2 889.75 14.01 2944 91089397 XP_974004.1 3350 0.0e+00 PREDICTED: pyridoxal-dependent decarboxylase domain-containing protein 1 [Tribolium castaneum]>gi|270011423|gb|EFA07871.1| hypothetical protein TcasGA2_TC005445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DF78 1043 9.0e-112 Pyridoxal-dependent decarboxylase domain-containing protein 1 OS=Xenopus laevis GN=pdxdc1 PE=2 SV=1 PF00282//PF00964 Pyridoxal-dependent decarboxylase conserved domain//Elicitin GO:0006952//GO:0019752//GO:0009405 defense response//carboxylic acid metabolic process//pathogenesis GO:0030170//GO:0016831 pyridoxal phosphate binding//carboxy-lyase activity GO:0005576 extracellular region KOG0630 Predicted pyridoxal-dependent decarboxylase Cluster-8309.42401 BF_2 49.78 0.42 5207 478253546 ENN73864.1 968 1.9e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.95072e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 1.0e-81 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF06814//PF01529 Peptidase family M50//Lung seven transmembrane receptor//DHHC palmitoyltransferase GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0016021 integral component of membrane KOG2585 Uncharacterized conserved protein Cluster-8309.42402 BF_2 1153.38 11.67 4420 91082195 XP_971684.1 1399 1.7e-151 PREDICTED: nipped-B-like protein B [Tribolium castaneum]>gi|270007443|gb|EFA03891.1| hypothetical protein TcasGA2_TC014015 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T200 132 5.8e-06 Zinc finger CCCH domain-containing protein 13 OS=Homo sapiens GN=ZC3H13 PE=1 SV=1 PF00642//PF03176 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//MMPL family -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.42403 BF_2 1826.59 16.65 4876 861599125 KMQ83546.1 322 1.5e-26 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF13404 Transposase//AsnC-type helix-turn-helix domain GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0043565//GO:0003677 sequence-specific DNA binding//DNA binding -- -- -- -- Cluster-8309.42404 BF_2 42.47 0.38 4943 861599125 KMQ83546.1 644 6.8e-64 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404//PF01498 AsnC-type helix-turn-helix domain//Transposase GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0043565//GO:0003677 sequence-specific DNA binding//DNA binding -- -- -- -- Cluster-8309.42405 BF_2 186.00 4.23 2127 189235300 XP_974730.2 707 1.4e-71 PREDICTED: la-related protein 7 [Tribolium castaneum]>gi|270004171|gb|EFA00619.1| hypothetical protein TcasGA2_TC003495 [Tribolium castaneum] -- -- -- -- -- K15191 LARP7 La-related protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K15191 Q7ZWE3 360 1.0e-32 La-related protein 7 OS=Danio rerio GN=larp7 PE=2 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding GO:0044424 intracellular part KOG0118 FOG: RRM domain Cluster-8309.42406 BF_2 67.21 1.37 2342 642917967 XP_008198963.1 2827 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] -- -- -- -- -- K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1249 9.3e-136 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF01494//PF07992//PF01266//PF12831//PF00070 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0006563//GO:0006566//GO:0055114//GO:0006546//GO:0006544 L-serine metabolic process//threonine metabolic process//oxidation-reduction process//glycine catabolic process//glycine metabolic process GO:0071949//GO:0016491//GO:0004047 FAD binding//oxidoreductase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.42407 BF_2 219.92 4.46 2348 642917967 XP_008198963.1 2995 0.0e+00 PREDICTED: pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial [Tribolium castaneum]>gi|270004690|gb|EFA01138.1| hypothetical protein TcasGA2_TC010363 [Tribolium castaneum] 194767821 XM_001965977.1 50 1.70036e-14 Drosophila ananassae GF19457 (Dana\GF19457), mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 1335 9.9e-146 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF12831//PF00070//PF07992//PF01266 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase GO:0006544//GO:0055114//GO:0006546//GO:0006566//GO:0006563 glycine metabolic process//oxidation-reduction process//glycine catabolic process//threonine metabolic process//L-serine metabolic process GO:0004047//GO:0016491 aminomethyltransferase activity//oxidoreductase activity GO:0005737 cytoplasm KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.42408 BF_2 2573.18 21.62 5267 189238186 XP_966734.2 2332 1.3e-259 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 642925605 XM_008196416.1 565 0 PREDICTED: Tribolium castaneum hippocampus abundant transcript 1 protein (LOC661725), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 6.7e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF07690//PF00400 Major Facilitator Superfamily//WD domain, G-beta repeat GO:0055085 transmembrane transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.42409 BF_2 48.89 2.98 973 759067723 XP_011343342.1 228 2.3e-16 PREDICTED: hippocampus abundant transcript 1 protein isoform X1 [Cerapachys biroi]>gi|759067725|ref|XP_011343343.1| PREDICTED: hippocampus abundant transcript 1 protein isoform X1 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q5SR56 141 1.2e-07 Hippocampus abundant transcript-like protein 1 OS=Homo sapiens GN=HIATL1 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.42410 BF_2 42.66 0.35 5355 189238186 XP_966734.2 2332 1.4e-259 PREDICTED: coronin-6 [Tribolium castaneum]>gi|270008836|gb|EFA05284.1| hypothetical protein TcasGA2_TC015441 [Tribolium castaneum] 642925605 XM_008196416.1 555 0 PREDICTED: Tribolium castaneum hippocampus abundant transcript 1 protein (LOC661725), mRNA K13886 CORO1B_1C_6 coronin-1B/1C/6 http://www.genome.jp/dbget-bin/www_bget?ko:K13886 Q920M5 1443 6.8e-158 Coronin-6 OS=Mus musculus GN=Coro6 PE=2 SV=1 PF00400//PF07690 WD domain, G-beta repeat//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.42411 BF_2 2137.33 78.79 1422 728416984 AIY68330.1 1849 3.6e-204 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 763 1.3e-79 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.42412 BF_2 20.00 0.32 2873 728417062 AIY68332.1 292 2.6e-23 putative integument esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 P35502 231 1.3e-17 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.42413 BF_2 39.06 0.31 5484 91076774 XP_973840.1 1189 4.8e-127 PREDICTED: autophagy protein 5 [Tribolium castaneum]>gi|270001850|gb|EEZ98297.1| hypothetical protein TcasGA2_TC000747 [Tribolium castaneum] 170060949 XM_001865993.1 65 1.83658e-22 Culex quinquefasciatus Autophagy-specific protein, mRNA K08339 ATG5 autophagy-related protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08339 Q9W3R7 857 6.2e-90 Autophagy protein 5 OS=Drosophila melanogaster GN=Atg5 PE=2 SV=2 PF06309//PF04106//PF16094//PF07728 Torsin//Autophagy protein Apg5//Proteasome assembly chaperone 4//AAA domain (dynein-related subfamily) GO:0043248//GO:0006914 proteasome assembly//autophagy GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0005737//GO:0005783 cytoplasm//endoplasmic reticulum KOG2170 ATPase of the AAA+ superfamily Cluster-8309.42414 BF_2 723.80 5.47 5823 189238796 XP_974873.2 578 3.6e-56 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] -- -- -- -- -- K01265 map methionyl aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01265 Q4VBS4 427 4.8e-40 Methionine aminopeptidase 1D, mitochondrial OS=Danio rerio GN=metap1d PE=2 SV=1 -- -- GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus KOG2738 Putative methionine aminopeptidase Cluster-8309.42415 BF_2 1086.00 8.18 5843 642916547 XP_008191645.1 1931 4.6e-213 PREDICTED: uncharacterized protein LOC103312116 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q792Q4 427 4.8e-40 Cysteine-rich PDZ-binding protein OS=Rattus norvegicus GN=Cript PE=1 SV=1 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3476 Microtubule-associated protein CRIPT Cluster-8309.42418 BF_2 229.56 1.58 6365 642914286 XP_008201622.1 2509 4.8e-280 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X2 [Tribolium castaneum] 642914285 XM_008203400.1 534 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 6-like (LOC663221), transcript variant X2, mRNA K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 Q8VEG6 1589 9.5e-175 CCR4-NOT transcription complex subunit 6-like OS=Mus musculus GN=Cnot6l PE=1 SV=2 PF13855//PF14987//PF06988//PF00560//PF01465//PF16093//PF08395 Leucine rich repeat//NADH dehydrogenase 1 alpha subcomplex subunit 3//NifT/FixU protein//Leucine Rich Repeat//GRIP domain//Proteasome assembly chaperone 4//7tm Chemosensory receptor GO:0000042//GO:0043248//GO:0050909//GO:0009399 protein targeting to Golgi//proteasome assembly//sensory perception of taste//nitrogen fixation GO:0005515 protein binding GO:0005747//GO:0016021//GO:0005743 mitochondrial respiratory chain complex I//integral component of membrane//mitochondrial inner membrane KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.42419 BF_2 583.46 3.65 6968 642914286 XP_008201622.1 2509 5.3e-280 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X2 [Tribolium castaneum] 642914285 XM_008203400.1 534 0 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 6-like (LOC663221), transcript variant X2, mRNA K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 Q8VEG6 1589 1.0e-174 CCR4-NOT transcription complex subunit 6-like OS=Mus musculus GN=Cnot6l PE=1 SV=2 PF08395//PF01465//PF16093//PF00560//PF06988//PF14987//PF13855 7tm Chemosensory receptor//GRIP domain//Proteasome assembly chaperone 4//Leucine Rich Repeat//NifT/FixU protein//NADH dehydrogenase 1 alpha subcomplex subunit 3//Leucine rich repeat GO:0009399//GO:0000042//GO:0043248//GO:0050909 nitrogen fixation//protein targeting to Golgi//proteasome assembly//sensory perception of taste GO:0005515 protein binding GO:0016021//GO:0005743//GO:0005747 integral component of membrane//mitochondrial inner membrane//mitochondrial respiratory chain complex I KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.42424 BF_2 1026.26 16.95 2820 91087199 XP_966953.1 1966 2.0e-217 PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|642929856|ref|XP_008196002.1| PREDICTED: sorting nexin-2 [Tribolium castaneum]>gi|270009518|gb|EFA05966.1| hypothetical protein TcasGA2_TC008785 [Tribolium castaneum] -- -- -- -- -- K17917 SNX1_2 sorting nexin-1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K17917 Q9CWK8 1117 2.3e-120 Sorting nexin-2 OS=Mus musculus GN=Snx2 PE=1 SV=2 PF00787//PF01025 PX domain//GrpE GO:0007154//GO:0006457 cell communication//protein folding GO:0035091//GO:0000774//GO:0051087//GO:0042803 phosphatidylinositol binding//adenyl-nucleotide exchange factor activity//chaperone binding//protein homodimerization activity -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.42425 BF_2 602.68 5.84 4605 642915700 XP_008190765.1 3280 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X3 [Tribolium castaneum] 642915699 XM_008192543.1 679 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 899 7.0e-95 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.42426 BF_2 649.60 6.24 4639 270013465 EFA09913.1 1341 9.6e-145 hypothetical protein TcasGA2_TC012064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02663 568 1.7e-56 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF07690//PF00083//PF04101//PF00201 Major Facilitator Superfamily//Sugar (and other) transporter//Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0055085 metabolic process//transmembrane transport GO:0016758//GO:0022857 transferase activity, transferring hexosyl groups//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.42429 BF_2 180.80 0.74 10537 91077334 XP_974850.1 2102 1.2e-232 PREDICTED: amidophosphoribosyltransferase [Tribolium castaneum]>gi|270001665|gb|EEZ98112.1| hypothetical protein TcasGA2_TC000530 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1736 1.4e-191 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF00156//PF01166//PF10473//PF17060//PF00769//PF13405//PF04111//PF11380//PF02465//PF01401//PF04728//PF05404//PF00038//PF04632//PF07851//PF04508 Phosphoribosyl transferase domain//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Monopolar spindle protein 2//Ezrin/radixin/moesin family//EF-hand domain//Autophagy protein Apg6//Stealth protein CR2, conserved region 2//Flagellar hook-associated protein 2 N-terminus//Angiotensin-converting enzyme//Lipoprotein leucine-zipper//Translocon-associated protein, delta subunit precursor (TRAP-delta)//Intermediate filament protein//Fusaric acid resistance protein family//TMPIT-like protein//Viral A-type inclusion protein repeat GO:0006189//GO:0006914//GO:0006536//GO:0009113//GO:0006810//GO:0006355//GO:0009116//GO:0006541//GO:0006144//GO:0071988//GO:0016032//GO:0030474//GO:0006508 'de novo' IMP biosynthetic process//autophagy//glutamate metabolic process//purine nucleobase biosynthetic process//transport//regulation of transcription, DNA-templated//nucleoside metabolic process//glutamine metabolic process//purine nucleobase metabolic process//protein localization to spindle pole body//viral process//spindle pole body duplication//proteolysis GO:0005198//GO:0051536//GO:0042803//GO:0008134//GO:0045502//GO:0008241//GO:0016772//GO:0004044//GO:0003700//GO:0008092//GO:0005509//GO:0008237//GO:0046872 structural molecule activity//iron-sulfur cluster binding//protein homodimerization activity//transcription factor binding//dynein binding//peptidyl-dipeptidase activity//transferase activity, transferring phosphorus-containing groups//amidophosphoribosyltransferase activity//transcription factor activity, sequence-specific DNA binding//cytoskeletal protein binding//calcium ion binding//metallopeptidase activity//metal ion binding GO:0016021//GO:0005737//GO:0005886//GO:0019867//GO:0005783//GO:0016020//GO:0019898//GO:0005882//GO:0030286//GO:0005667//GO:0009424 integral component of membrane//cytoplasm//plasma membrane//outer membrane//endoplasmic reticulum//membrane//extrinsic component of membrane//intermediate filament//dynein complex//transcription factor complex//bacterial-type flagellum hook KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.42434 BF_2 8.00 0.37 1186 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42435 BF_2 109.92 0.48 9917 91085247 XP_973234.1 3413 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 53 homolog [Tribolium castaneum]>gi|270008454|gb|EFA04902.1| hypothetical protein TcasGA2_TC014966 [Tribolium castaneum] 642926486 XM_968141.2 316 9.82343e-162 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 53 homolog (LOC662014), mRNA -- -- -- -- Q5ZLD7 2247 7.4e-251 Vacuolar protein sorting-associated protein 53 homolog OS=Gallus gallus GN=VPS53 PE=2 SV=1 PF05997//PF11698//PF08064//PF02985//PF00015//PF00083//PF07690//PF14372//PF06009 Nucleolar protein,Nop52//V-ATPase subunit H//UME (NUC010) domain//HEAT repeat//Methyl-accepting chemotaxis protein (MCP) signalling domain//Sugar (and other) transporter//Major Facilitator Superfamily//Domain of unknown function (DUF4413)//Laminin Domain II GO:0006364//GO:0009069//GO:0007165//GO:0055085//GO:0007155//GO:0016310//GO:0015991 rRNA processing//serine family amino acid metabolic process//signal transduction//transmembrane transport//cell adhesion//phosphorylation//ATP hydrolysis coupled proton transport GO:0004674//GO:0004871//GO:0016820//GO:0005515//GO:0003677//GO:0022857 protein serine/threonine kinase activity//signal transducer activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//DNA binding//transmembrane transporter activity GO:0030688//GO:0016021//GO:0016020//GO:0000221 preribosome, small subunit precursor//integral component of membrane//membrane//vacuolar proton-transporting V-type ATPase, V1 domain KOG2180 Late Golgi protein sorting complex, subunit Vps53 Cluster-8309.42436 BF_2 6.73 0.35 1096 676456525 XP_009054352.1 244 3.6e-18 hypothetical protein LOTGIDRAFT_189035 [Lottia gigantea]>gi|556106513|gb|ESO95165.1| hypothetical protein LOTGIDRAFT_189035 [Lottia gigantea] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 179 5.1e-12 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF02088 Ornatin GO:0030193//GO:0007155 regulation of blood coagulation//cell adhesion -- -- GO:0005576 extracellular region KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.42437 BF_2 338.36 3.72 4097 642924882 XP_008194082.1 2220 1.0e-246 PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|642924884|ref|XP_008194083.1| PREDICTED: serine/threonine-protein kinase MST4 isoform X1 [Tribolium castaneum]>gi|270008015|gb|EFA04463.1| hypothetical protein TcasGA2_TC014767 [Tribolium castaneum] 795080210 XM_012021821.1 347 2.36304e-179 PREDICTED: Vollenhovia emeryi serine/threonine-protein kinase 25 (LOC105567182), transcript variant X6, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 B0LT89 1090 4.4e-117 Serine/threonine-protein kinase 24 OS=Rattus norvegicus GN=Stk24 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.42440 BF_2 84.52 1.26 3097 642930308 XP_008196340.1 1113 1.8e-118 PREDICTED: bromodomain-containing protein 8 [Tribolium castaneum]>gi|270010708|gb|EFA07156.1| hypothetical protein TcasGA2_TC010150 [Tribolium castaneum] -- -- -- -- -- K11321 BRD8 bromodomain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11321 Q9H0E9 379 9.3e-35 Bromodomain-containing protein 8 OS=Homo sapiens GN=BRD8 PE=1 SV=2 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42442 BF_2 339.20 4.42 3495 649572249 NP_001280546.1 2673 2.5e-299 protein Skeletor, isoforms B/C precursor [Tribolium castaneum]>gi|270012993|gb|EFA09441.1| hypothetical protein TcasGA2_TC010653 [Tribolium castaneum]>gi|343787531|gb|AEM60136.1| knickkopf [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGY6 753 4.5e-78 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42443 BF_2 1214.92 94.85 823 91076392 XP_968727.1 1126 1.4e-120 PREDICTED: proteasome subunit alpha type-2 [Tribolium castaneum]>gi|270002557|gb|EEZ99004.1| hypothetical protein TcasGA2_TC004868 [Tribolium castaneum] 389611552 AK402776.1 159 1.48187e-75 Papilio xuthus mRNA for proteasome 25kD subunit, partial cds, sequence id: Px-0378, expressed in epidermis K02726 PSMA2 20S proteasome subunit alpha 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02726 P40301 1020 1.2e-109 Proteasome subunit alpha type-2 OS=Drosophila melanogaster GN=Prosalpha2 PE=1 SV=1 PF10584//PF00227 Proteasome subunit A N-terminal signature//Proteasome subunit GO:0051603//GO:0006511 proteolysis involved in cellular protein catabolic process//ubiquitin-dependent protein catabolic process GO:0004298//GO:0004175 threonine-type endopeptidase activity//endopeptidase activity GO:0005737//GO:0019773//GO:0005839//GO:0005634 cytoplasm//proteasome core complex, alpha-subunit complex//proteasome core complex//nucleus KOG0181 20S proteasome, regulatory subunit alpha type PSMA2/PRE8 Cluster-8309.42445 BF_2 1433.74 27.33 2482 91080689 XP_975235.1 1580 9.9e-173 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial [Tribolium castaneum]>gi|270006426|gb|EFA02874.1| hypothetical protein TcasGA2_TC007967 [Tribolium castaneum] 642919565 XM_970142.2 154 2.76514e-72 PREDICTED: Tribolium castaneum NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial (LOC664127), mRNA K03953 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K03953 P34943 747 1.6e-77 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial OS=Bos taurus GN=NDUFA9 PE=1 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210//GO:0044237 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process//cellular metabolic process GO:0000166//GO:0003824//GO:0050662//GO:0003854//GO:0016616 nucleotide binding//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2865 NADH:ubiquinone oxidoreductase, NDUFA9/39kDa subunit Cluster-8309.42446 BF_2 16.00 2.33 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42448 BF_2 71.00 2.38 1533 642929701 XP_008195941.1 161 2.1e-08 PREDICTED: uncharacterized protein LOC103313715 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42450 BF_2 460.00 18.92 1304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42451 BF_2 2196.71 13.30 7195 189234936 XP_971620.2 2104 5.0e-233 PREDICTED: probable sulfite oxidase, mitochondrial [Tribolium castaneum]>gi|642914911|ref|XP_008190439.1| PREDICTED: probable sulfite oxidase, mitochondrial [Tribolium castaneum]>gi|642914914|ref|XP_008190440.1| PREDICTED: probable sulfite oxidase, mitochondrial [Tribolium castaneum]>gi|270001403|gb|EEZ97850.1| hypothetical protein TcasGA2_TC000220 [Tribolium castaneum] 642914909 XM_966579.3 195 1.30565e-94 PREDICTED: Tribolium castaneum ubiquitin domain-containing protein 2 (LOC660341), mRNA K00387 SUOX sulfite oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00387 Q9VWP4 1553 1.6e-170 Probable sulfite oxidase, mitochondrial OS=Drosophila melanogaster GN=CG7280 PE=2 SV=1 PF00240//PF00174//PF01365//PF03404 Ubiquitin family//Oxidoreductase molybdopterin binding domain//RIH domain//Mo-co oxidoreductase dimerisation domain GO:0055114//GO:0006118//GO:0070588//GO:0042128//GO:0006816 oxidation-reduction process//obsolete electron transport//calcium ion transmembrane transport//nitrate assimilation//calcium ion transport GO:0020037//GO:0009055//GO:0005515//GO:0030151//GO:0016491//GO:0005262 heme binding//electron carrier activity//protein binding//molybdenum ion binding//oxidoreductase activity//calcium channel activity GO:0016020 membrane KOG0535 Sulfite oxidase, molybdopterin-binding component Cluster-8309.42454 BF_2 85.46 1.97 2101 91078068 XP_971672.1 239 2.6e-17 PREDICTED: ubiquitin domain-containing protein 2 [Tribolium castaneum]>gi|270002315|gb|EEZ98762.1| hypothetical protein TcasGA2_TC001326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91WB7 136 9.5e-07 Ubiquitin domain-containing protein 1 OS=Mus musculus GN=Ubtd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42455 BF_2 107.04 1.25 3873 91078068 XP_971672.1 239 4.9e-17 PREDICTED: ubiquitin domain-containing protein 2 [Tribolium castaneum]>gi|270002315|gb|EEZ98762.1| hypothetical protein TcasGA2_TC001326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68FV8 136 1.8e-06 Ubiquitin domain-containing protein 1 OS=Rattus norvegicus GN=Ubtd1 PE=2 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42456 BF_2 99.56 1.28 3538 91092538 XP_967850.1 1519 1.7e-165 PREDICTED: ras-related GTP-binding protein A [Tribolium castaneum]>gi|270006620|gb|EFA03068.1| hypothetical protein TcasGA2_TC010924 [Tribolium castaneum] 332372815 BT126586.1 193 8.26574e-94 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q3SX43 1348 4.6e-147 Ras-related GTP-binding protein A OS=Bos taurus GN=RRAGA PE=2 SV=1 PF07516//PF00025//PF08477//PF01926//PF00503//PF00484//PF04670//PF10662//PF00071//PF00005//PF03193 SecA Wing and Scaffold domain//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//G-protein alpha subunit//Carbonic anhydrase//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//ABC transporter//Protein of unknown function, DUF258 GO:0007165//GO:0017038//GO:0007186//GO:0006730//GO:0006576//GO:0007264//GO:0006807 signal transduction//protein import//G-protein coupled receptor signaling pathway//one-carbon metabolic process//cellular biogenic amine metabolic process//small GTPase mediated signal transduction//nitrogen compound metabolic process GO:0003924//GO:0005524//GO:0031683//GO:0008270//GO:0016887//GO:0019001//GO:0004089//GO:0005525//GO:0004871 GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//zinc ion binding//ATPase activity//guanyl nucleotide binding//carbonate dehydratase activity//GTP binding//signal transducer activity GO:0005737//GO:0005634//GO:0016020 cytoplasm//nucleus//membrane KOG3886 GTP-binding protein Cluster-8309.42457 BF_2 67.55 3.76 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42459 BF_2 1278.19 12.64 4519 642925855 XP_008190573.1 1338 2.1e-144 PREDICTED: nicastrin [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q9VC27 807 3.2e-84 Nicastrin OS=Drosophila melanogaster GN=nct PE=1 SV=3 PF05450//PF00328 Nicastrin//Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771//GO:0016485 hexachlorocyclohexane metabolic process//riboflavin metabolic process//protein processing GO:0003993 acid phosphatase activity GO:0016021 integral component of membrane -- -- Cluster-8309.42461 BF_2 75.00 2.63 1482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42469 BF_2 169.95 1.95 3941 642913457 XP_008201020.1 4044 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.0e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00023//PF00784 Ankyrin repeat//Ankyrin repeat//MyTH4 domain -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.42471 BF_2 26.69 0.40 3046 642913255 XP_008201459.1 819 2.1e-84 PREDICTED: RNA-binding protein squid isoform X1 [Tribolium castaneum]>gi|270001992|gb|EEZ98439.1| hypothetical protein TcasGA2_TC000928 [Tribolium castaneum] 506968668 KC740854.1 175 7.20572e-84 Coptotermes formosanus clone CFSNI578 RNA recognition motif (RRM) mRNA, partial cds K03102 SQD squid http://www.genome.jp/dbget-bin/www_bget?ko:K03102 Q08473 716 7.7e-74 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.42472 BF_2 162.72 2.05 3606 91086687 XP_969129.1 2459 1.7e-274 PREDICTED: tyrosine-protein kinase Src42A isoform X2 [Tribolium castaneum] 242015483 XM_002428338.1 244 3.75742e-122 Pediculus humanus corporis tyrosine-protein kinase Src42A, putative, mRNA K08892 FRK, PTK5 fyn-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08892 Q9V9J3 2167 5.1e-242 Tyrosine-protein kinase Src42A OS=Drosophila melanogaster GN=Src42A PE=2 SV=1 PF07714//PF06293//PF00069//PF14604//PF00018 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Variant SH3 domain//SH3 domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0005515//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//protein kinase activity GO:0016020 membrane KOG0197 Tyrosine kinases Cluster-8309.42473 BF_2 1158.70 11.64 4451 646718564 KDR20976.1 3498 0.0e+00 Formin-like protein, partial [Zootermopsis nevadensis] 837785995 XM_012926268.1 41 3.26762e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1597 7.8e-176 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF06367//PF08671//PF06371//PF02734//PF04627 Diaphanous FH3 Domain//Anti-repressor SinI//Diaphanous GTPase-binding Domain//DAK2 domain//Mitochondrial ATP synthase epsilon chain GO:0006119//GO:0016043//GO:0015986//GO:0006355//GO:0015992//GO:0006071//GO:0046486//GO:0030036 oxidative phosphorylation//cellular component organization//ATP synthesis coupled proton transport//regulation of transcription, DNA-templated//proton transport//glycerol metabolic process//glycerolipid metabolic process//actin cytoskeleton organization GO:0046983//GO:0017048//GO:0004371//GO:0003779//GO:0046933//GO:0046961 protein dimerization activity//Rho GTPase binding//glycerone kinase activity//actin binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism GO:0000275//GO:0045259 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex KOG1923 Rac1 GTPase effector FRL Cluster-8309.42474 BF_2 59.26 0.44 5864 646718564 KDR20976.1 3302 0.0e+00 Formin-like protein, partial [Zootermopsis nevadensis] 837785995 XM_012926268.1 41 4.3134e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1597 1.0e-175 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF02734//PF04627//PF06367//PF08671//PF06371 DAK2 domain//Mitochondrial ATP synthase epsilon chain//Diaphanous FH3 Domain//Anti-repressor SinI//Diaphanous GTPase-binding Domain GO:0015992//GO:0006071//GO:0046486//GO:0030036//GO:0006355//GO:0015986//GO:0006119//GO:0016043 proton transport//glycerol metabolic process//glycerolipid metabolic process//actin cytoskeleton organization//regulation of transcription, DNA-templated//ATP synthesis coupled proton transport//oxidative phosphorylation//cellular component organization GO:0046933//GO:0046961//GO:0004371//GO:0003779//GO:0017048//GO:0046983 proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//glycerone kinase activity//actin binding//Rho GTPase binding//protein dimerization activity GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG1923 Rac1 GTPase effector FRL Cluster-8309.42475 BF_2 48.04 0.45 4726 646718564 KDR20976.1 3302 0.0e+00 Formin-like protein, partial [Zootermopsis nevadensis] 837785995 XM_012926268.1 41 3.47115e-09 PREDICTED: Ochotona princeps formin-like 2 (FMNL2), transcript variant X2, mRNA -- -- -- -- Q9VUC6 1597 8.3e-176 Formin-like protein CG32138 OS=Drosophila melanogaster GN=CG32138 PE=1 SV=3 PF06371//PF01044//PF08671//PF06367//PF04627//PF02734 Diaphanous GTPase-binding Domain//Vinculin family//Anti-repressor SinI//Diaphanous FH3 Domain//Mitochondrial ATP synthase epsilon chain//DAK2 domain GO:0006071//GO:0015992//GO:0030036//GO:0046486//GO:0006355//GO:0016043//GO:0006119//GO:0007155//GO:0015986 glycerol metabolic process//proton transport//actin cytoskeleton organization//glycerolipid metabolic process//regulation of transcription, DNA-templated//cellular component organization//oxidative phosphorylation//cell adhesion//ATP synthesis coupled proton transport GO:0004371//GO:0003779//GO:0046933//GO:0046961//GO:0051015//GO:0046983//GO:0017048 glycerone kinase activity//actin binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//actin filament binding//protein dimerization activity//Rho GTPase binding GO:0045259//GO:0000275 proton-transporting ATP synthase complex//mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) KOG1923 Rac1 GTPase effector FRL Cluster-8309.42477 BF_2 7.49 0.40 1066 403234001 AFR31785.1 186 1.9e-11 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42480 BF_2 1104.15 10.66 4622 642915302 XP_008190562.1 1564 1.3e-170 PREDICTED: JNK-interacting protein 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58A65 1044 1.1e-111 C-Jun-amino-terminal kinase-interacting protein 4 OS=Mus musculus GN=Spag9 PE=1 SV=2 PF01080//PF03178 Presenilin//CPSF A subunit region -- -- GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.42482 BF_2 228.80 3.06 3420 546673279 ERL84915.1 371 2.1e-32 hypothetical protein D910_02338 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42484 BF_2 7.73 0.42 1056 642920880 XP_008192598.1 365 3.2e-32 PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum]>gi|642920882|ref|XP_008192599.1| PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SP67 309 4.2e-27 WD repeat-containing protein 26 OS=Danio rerio GN=wdr26 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.42485 BF_2 40.60 0.41 4380 642920880 XP_008192598.1 1586 3.5e-173 PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum]>gi|642920882|ref|XP_008192599.1| PREDICTED: WD repeat-containing protein 26 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7D7 1128 1.9e-121 WD repeat-containing protein 26 OS=Homo sapiens GN=WDR26 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.42487 BF_2 164.36 2.59 2938 270006128 EFA02576.1 1541 3.9e-168 hypothetical protein TcasGA2_TC008294 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7D7 1128 1.2e-121 WD repeat-containing protein 26 OS=Homo sapiens GN=WDR26 PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0293 WD40 repeat-containing protein Cluster-8309.42490 BF_2 149.95 2.88 2463 91089299 XP_971539.1 2343 3.3e-261 PREDICTED: uncharacterized protein LOC660192 [Tribolium castaneum] 642933045 XM_966446.2 324 8.62685e-167 PREDICTED: Tribolium castaneum uncharacterized LOC660192 (LOC660192), mRNA -- -- -- -- P16066 662 1.1e-67 Atrial natriuretic peptide receptor 1 OS=Homo sapiens GN=NPR1 PE=1 SV=1 PF07701//PF00211 Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain GO:0046039//GO:0006182//GO:0009190//GO:0035556//GO:0006144 GTP metabolic process//cGMP biosynthetic process//cyclic nucleotide biosynthetic process//intracellular signal transduction//purine nucleobase metabolic process GO:0004383//GO:0016849 guanylate cyclase activity//phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.42491 BF_2 296.27 5.91 2383 642925261 XP_008194484.1 311 1.3e-25 PREDICTED: ATP-dependent DNA helicase Q5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08236 SRI (Set2 Rpb1 interacting) domain GO:0006479//GO:0006355//GO:0006554//GO:0034968 protein methylation//regulation of transcription, DNA-templated//lysine catabolic process//histone lysine methylation GO:0018024 histone-lysine N-methyltransferase activity GO:0005694 chromosome -- -- Cluster-8309.42492 BF_2 19.00 0.71 1400 642934035 XP_008197614.1 458 7.1e-43 PREDICTED: transmembrane protein 17-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E1BY51 213 7.5e-16 Transmembrane protein 17 OS=Gallus gallus GN=TMEM17 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42493 BF_2 900.05 41.61 1192 91080235 XP_972829.1 892 2.9e-93 PREDICTED: caprin homolog [Tribolium castaneum]>gi|270005626|gb|EFA02074.1| hypothetical protein TcasGA2_TC007709 [Tribolium castaneum] -- -- -- -- -- K18743 CAPRIN1, GPIAP1 caprin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18743 Q9I7D3 338 2.0e-30 Caprin homolog OS=Drosophila melanogaster GN=Capr PE=1 SV=1 PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GO:0006633//GO:0006090 fatty acid biosynthetic process//pyruvate metabolic process GO:0003989 acetyl-CoA carboxylase activity GO:0009317 acetyl-CoA carboxylase complex -- -- Cluster-8309.42495 BF_2 224.73 5.26 2074 642931814 XP_008196744.1 1095 1.4e-116 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 797 2.1e-83 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.42496 BF_2 73.46 0.66 4970 817066161 XP_012254906.1 781 8.9e-80 PREDICTED: ribosomal protein S6 kinase beta-1 isoform X1 [Athalia rosae] 645004372 XM_008210703.1 107 7.46967e-46 PREDICTED: Nasonia vitripennis ribosomal protein S6 kinase beta-1-like (LOC100115857), transcript variant X3, mRNA K04688 RPS6KB p70 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04688 Q8BSK8 669 3.5e-68 Ribosomal protein S6 kinase beta-1 OS=Mus musculus GN=Rps6kb1 PE=1 SV=2 PF06293//PF00069//PF00433//PF07714//PF05180 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein kinase C terminal domain//Protein tyrosine kinase//DNL zinc finger GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004674//GO:0004672//GO:0008270//GO:0016773//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//zinc ion binding//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.42498 BF_2 552.17 2.73 8734 91090153 XP_972190.1 9530 0.0e+00 PREDICTED: CAD protein [Tribolium castaneum]>gi|270013749|gb|EFA10197.1| hypothetical protein TcasGA2_TC012392 [Tribolium castaneum] 218526269 EU860157.1 823 0 Strangalia bicolor carbamoyl-phosphate synthase (CAD) gene, partial cds K11540 CAD carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase http://www.genome.jp/dbget-bin/www_bget?ko:K11540 P05990 7863 0.0e+00 CAD protein OS=Drosophila melanogaster GN=r PE=1 SV=3 PF02729//PF01979//PF07478//PF02786//PF07722//PF02655//PF00185//PF00113 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain//Amidohydrolase family//D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//Peptidase C26//ATP-grasp domain//Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain//Enolase, C-terminal TIM barrel domain GO:0006571//GO:0006541//GO:0006094//GO:0006207//GO:0006096//GO:0000162//GO:0006543//GO:0006807//GO:0009252//GO:0006520//GO:0009094//GO:0006206//GO:0006522//GO:0046436//GO:0006531//GO:0070409 tyrosine biosynthetic process//glutamine metabolic process//gluconeogenesis//'de novo' pyrimidine nucleobase biosynthetic process//glycolytic process//tryptophan biosynthetic process//glutamine catabolic process//nitrogen compound metabolic process//peptidoglycan biosynthetic process//cellular amino acid metabolic process//L-phenylalanine biosynthetic process//pyrimidine nucleobase metabolic process//alanine metabolic process//D-alanine metabolic process//aspartate metabolic process//carbamoyl phosphate biosynthetic process GO:0004634//GO:0005524//GO:0016787//GO:0008716//GO:0000287//GO:0004070//GO:0046872//GO:0016597//GO:0016812//GO:0016743 phosphopyruvate hydratase activity//ATP binding//hydrolase activity//D-alanine-D-alanine ligase activity//magnesium ion binding//aspartate carbamoyltransferase activity//metal ion binding//amino acid binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides//carboxyl- or carbamoyltransferase activity GO:0009347//GO:0000015 aspartate carbamoyltransferase complex//phosphopyruvate hydratase complex KOG0370 Multifunctional pyrimidine synthesis protein CAD (includes carbamoyl-phophate synthetase, aspartate transcarbamylase, and glutamine amidotransferase) Cluster-8309.4250 BF_2 8.45 0.80 728 826494638 XP_012540802.1 405 5.1e-37 PREDICTED: pleckstrin homology domain-containing family F member 2 isoform X1 [Monomorium pharaonis] 755945962 XM_011301681.1 89 1.0663e-36 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 352 3.0e-32 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1729 FYVE finger containing protein Cluster-8309.42501 BF_2 741.76 9.99 3392 91091602 XP_975764.1 2842 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X7 [Tribolium castaneum] 642937044 XM_970671.2 557 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X7, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 1982 1.4e-220 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF11540//PF09266//PF00400 Cytoplasmic dynein 1 intermediate chain 2//Viral DNA topoisomerase I, N-terminal//WD domain, G-beta repeat GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0005515//GO:0003916//GO:0003677 protein binding//DNA topoisomerase activity//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.42502 BF_2 14.80 0.38 1897 282165788 NP_001164133.1 722 2.3e-73 scavenger receptor protein [Tribolium castaneum]>gi|270009221|gb|EFA05669.1| hypothetical protein TcasGA2_TC014951 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61009 350 1.3e-31 Scavenger receptor class B member 1 OS=Mus musculus GN=Scarb1 PE=1 SV=1 PF01130//PF04790 CD36 family//Sarcoglycan complex subunit protein GO:0007155 cell adhesion -- -- GO:0016012//GO:0016021//GO:0016020 sarcoglycan complex//integral component of membrane//membrane -- -- Cluster-8309.42503 BF_2 22.49 0.46 2337 642911849 XP_008200772.1 158 7.2e-08 PREDICTED: zinc transporter 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00276 Ribosomal protein L23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.42504 BF_2 784.39 20.69 1873 478262468 ENN81139.1 1449 1.2e-157 hypothetical protein YQE_02506, partial [Dendroctonus ponderosae]>gi|546672781|gb|ERL84537.1| hypothetical protein D910_01967 [Dendroctonus ponderosae] -- -- -- -- -- K14689 SLC30A2, ZNT2 solute carrier family 30 (zinc transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14689 Q2HJ10 917 2.3e-97 Zinc transporter 2 OS=Mus musculus GN=Slc30a2 PE=2 SV=1 PF01545 Cation efflux family GO:0055085//GO:0006812 transmembrane transport//cation transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1482 Zn2+ transporter Cluster-8309.42506 BF_2 23.10 2.18 731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42507 BF_2 131.03 0.97 5929 91092090 XP_971602.1 1246 1.3e-133 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 Q0P678 341 4.6e-30 Zinc finger CCCH domain-containing protein 18 OS=Mus musculus GN=Zc3h18 PE=1 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.42508 BF_2 122.75 0.93 5802 91092090 XP_971602.1 1246 1.2e-133 PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|642917996|ref|XP_008198975.1| PREDICTED: zinc finger CCCH domain-containing protein 18 [Tribolium castaneum]>gi|270004675|gb|EFA01123.1| hypothetical protein TcasGA2_TC010336 [Tribolium castaneum] -- -- -- -- -- K13092 ZC3H18 nuclear protein NHN1 http://www.genome.jp/dbget-bin/www_bget?ko:K13092 Q0P678 341 4.5e-30 Zinc finger CCCH domain-containing protein 18 OS=Mus musculus GN=Zc3h18 PE=1 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0005488 metal ion binding//binding -- -- -- -- Cluster-8309.42510 BF_2 15.62 0.31 2405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42511 BF_2 355.61 3.21 4928 189240067 XP_970199.2 2407 2.5e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.25696e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 4.9e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF05480//PF07690//PF00083//PF08040 Staphylococcus haemolytic protein//Major Facilitator Superfamily//Sugar (and other) transporter//MNLL subunit GO:0009405//GO:0006118//GO:0055085 pathogenesis//obsolete electron transport//transmembrane transport GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.42512 BF_2 60.51 1.04 2732 91092400 XP_969218.1 1516 2.9e-165 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 624 3.2e-63 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.42513 BF_2 22.02 0.59 1840 91092400 XP_969218.1 763 4.0e-78 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 360 8.9e-33 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.42516 BF_2 309.95 6.28 2351 189234632 XP_001815875.1 1000 1.7e-105 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.30688e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42518 BF_2 337.57 1.33 10942 270008428 EFA04876.1 9007 0.0e+00 hypothetical protein TcasGA2_TC014935 [Tribolium castaneum] -- -- -- -- -- K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 P42356 4980 0.0e+00 Phosphatidylinositol 4-kinase alpha OS=Homo sapiens GN=PI4KA PE=1 SV=3 PF00106//PF00515//PF13374//PF13414//PF00107//PF13181//PF07721//PF08240//PF00454//PF00899 short chain dehydrogenase//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Zinc-binding dehydrogenase//Tetratricopeptide repeat//Tetratricopeptide repeat//Alcohol dehydrogenase GroES-like domain//Phosphatidylinositol 3- and 4-kinase//ThiF family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0005515//GO:0008641//GO:0042802//GO:0016773 oxidoreductase activity//protein binding//small protein activating enzyme activity//identical protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0902 Phosphatidylinositol 4-kinase Cluster-8309.42519 BF_2 1420.81 102.15 869 264667459 ACY71315.1 524 9.8e-51 ribosomal protein L28 [Chrysomela tremula] -- -- -- -- -- K02903 RP-L28e, RPL28 large subunit ribosomal protein L28e http://www.genome.jp/dbget-bin/www_bget?ko:K02903 Q962T2 427 7.1e-41 60S ribosomal protein L28 OS=Spodoptera frugiperda GN=RpL28 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3412 60S ribosomal protein L28 Cluster-8309.42520 BF_2 198.00 27.90 584 189234118 XP_001811130.1 318 5.1e-27 PREDICTED: ATP-dependent RNA helicase A [Tribolium castaneum]>gi|270002525|gb|EEZ98972.1| hypothetical protein TcasGA2_TC004827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42524 BF_2 600.44 4.32 6096 642911420 XP_008199415.1 4264 0.0e+00 PREDICTED: insulin-like receptor [Tribolium castaneum]>gi|642911422|ref|XP_008199416.1| PREDICTED: insulin-like receptor [Tribolium castaneum] 887513390 KP331063.1 128 1.94419e-57 Leptinotarsa decemlineata insulin-like receptor (INR) mRNA, complete cds K04527 INSR insulin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04527 Q93105 2776 2.0e-312 Insulin-like receptor OS=Aedes aegypti GN=InR PE=2 SV=2 PF00069//PF07714//PF00757//PF00041 Protein kinase domain//Protein tyrosine kinase//Furin-like cysteine rich region//Fibronectin type III domain GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0005515//GO:0004714//GO:0004672 ATP binding//protein binding//transmembrane receptor protein tyrosine kinase activity//protein kinase activity GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.42525 BF_2 7375.85 34.06 9347 642927139 XP_008195153.1 10566 0.0e+00 PREDICTED: talin-1 isoform X1 [Tribolium castaneum]>gi|642927141|ref|XP_008195154.1| PREDICTED: talin-1 isoform X1 [Tribolium castaneum] 645021046 XM_008209207.1 107 1.40902e-45 PREDICTED: Nasonia vitripennis talin-2 (LOC100123995), mRNA K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 5938 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01608//PF02174//PF03081//PF01044//PF09141//PF01025 I/LWEQ domain//PTB domain (IRS-1 type)//Exo70 exocyst complex subunit//Vinculin family//Talin, middle domain//GrpE GO:0007155//GO:0006887//GO:0006457//GO:0007165//GO:0007016 cell adhesion//exocytosis//protein folding//signal transduction//cytoskeletal anchoring at plasma membrane GO:0042803//GO:0005200//GO:0051087//GO:0051015//GO:0000774//GO:0003779//GO:0005158 protein homodimerization activity//structural constituent of cytoskeleton//chaperone binding//actin filament binding//adenyl-nucleotide exchange factor activity//actin binding//insulin receptor binding GO:0000145//GO:0005899//GO:0001726//GO:0005856//GO:0005925 exocyst//insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.42526 BF_2 151.76 0.54 11959 642927143 XP_008195155.1 8604 0.0e+00 PREDICTED: talin-1 isoform X2 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.81714e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01608//PF09141//PF01025//PF01044//PF02174 I/LWEQ domain//Talin, middle domain//GrpE//Vinculin family//PTB domain (IRS-1 type) GO:0006457//GO:0007016//GO:0007165//GO:0007155 protein folding//cytoskeletal anchoring at plasma membrane//signal transduction//cell adhesion GO:0003779//GO:0005158//GO:0000774//GO:0051015//GO:0005200//GO:0051087//GO:0042803 actin binding//insulin receptor binding//adenyl-nucleotide exchange factor activity//actin filament binding//structural constituent of cytoskeleton//chaperone binding//protein homodimerization activity GO:0005899//GO:0005925//GO:0005856//GO:0001726 insulin receptor complex//focal adhesion//cytoskeleton//ruffle KOG0980 Actin-binding protein SLA2/Huntingtin-interacting protein Hip1 Cluster-8309.42527 BF_2 223.00 16.60 849 189240885 XP_971484.2 983 5.7e-104 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Tribolium castaneum] 642934610 XM_966391.3 152 1.19171e-71 PREDICTED: Tribolium castaneum splicing factor 3B subunit 1 (LOC660131), transcript variant X1, mRNA K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O57683 556 7.6e-56 Splicing factor 3B subunit 1 OS=Xenopus laevis GN=sf3b1 PE=2 SV=1 PF04162 Gyrovirus capsid protein (VP1) -- -- -- -- GO:0019028 viral capsid KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.42528 BF_2 265.00 24.11 747 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42529 BF_2 206.44 1.86 4937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.42531 BF_2 527.15 7.41 3264 642936982 XP_008198641.1 2270 1.3e-252 PREDICTED: bromodomain-containing protein 3-like isoform X4 [Tribolium castaneum] 642936987 XM_008200422.1 148 7.89335e-69 PREDICTED: Tribolium castaneum bromodomain-containing protein 3-like (LOC656325), transcript variant X11, mRNA K11721 BRD3 bromodomain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11721 Q15059 993 6.2e-106 Bromodomain-containing protein 3 OS=Homo sapiens GN=BRD3 PE=1 SV=1 PF01025//PF12761//PF08290//PF00439//PF13965 GrpE//Actin cytoskeleton-regulatory complex protein END3//Hepatitis core protein, putative zinc finger//Bromodomain//dsRNA-gated channel SID-1 GO:0015931//GO:0009405//GO:0006457//GO:0007015//GO:0006897//GO:0033227 nucleobase-containing compound transport//pathogenesis//protein folding//actin filament organization//endocytosis//dsRNA transport GO:0005198//GO:0005515//GO:0042803//GO:0051087//GO:0000774//GO:0051033 structural molecule activity//protein binding//protein homodimerization activity//chaperone binding//adenyl-nucleotide exchange factor activity//RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG1474 Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins Cluster-8309.42532 BF_2 416.13 5.26 3595 642936978 XP_008198639.1 774 4.2e-79 PREDICTED: bromodomain-containing protein 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13709 137 1.2e-06 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42533 BF_2 718.21 8.98 3634 642916768 XP_008192537.1 518 2.0e-49 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V3B7 326 1.5e-28 Peptidoglycan-recognition protein SC1a/b OS=Drosophila melanogaster GN=PGRP-SC1a PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0006807//GO:0009253//GO:0009252 nitrogen compound metabolic process//peptidoglycan catabolic process//peptidoglycan biosynthetic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.42535 BF_2 460.05 4.15 4930 478255570 ENN75787.1 1084 6.4e-115 hypothetical protein YQE_07744, partial [Dendroctonus ponderosae]>gi|546682060|gb|ERL92046.1| hypothetical protein D910_09368 [Dendroctonus ponderosae] 642913709 XM_008202908.1 121 1.22239e-53 PREDICTED: Tribolium castaneum acyl-CoA desaturase 1 (LOC662865), transcript variant X2, mRNA K00507 SCD, desC stearoyl-CoA desaturase (delta-9 desaturase) http://www.genome.jp/dbget-bin/www_bget?ko:K00507 O00767 737 4.6e-76 Acyl-CoA desaturase OS=Homo sapiens GN=SCD PE=1 SV=2 PF00487 Fatty acid desaturase GO:0006629 lipid metabolic process -- -- -- -- KOG1600 Fatty acid desaturase Cluster-8309.42538 BF_2 1250.69 9.50 5795 270006025 EFA02473.1 1249 5.6e-134 hypothetical protein TcasGA2_TC008164 [Tribolium castaneum] -- -- -- -- -- K14803 PTC2_3 protein phosphatase 2C homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14803 P49596 1031 4.4e-110 Probable protein phosphatase 2C T23F11.1 OS=Caenorhabditis elegans GN=ppm-2 PE=3 SV=2 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.42541 BF_2 1257.63 16.33 3508 270001368 EEZ97815.1 2124 1.2e-235 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 142 1.83776e-65 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 948 1.1e-100 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.42543 BF_2 65.05 0.74 3953 270001368 EEZ97815.1 2507 5.1e-280 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 90 1.67226e-36 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 1191 8.3e-129 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.42544 BF_2 723.36 7.37 4393 91078200 XP_968428.1 1053 2.3e-111 PREDICTED: m7GpppN-mRNA hydrolase [Tribolium castaneum]>gi|270001356|gb|EEZ97803.1| hypothetical protein TcasGA2_TC000167 [Tribolium castaneum] -- -- -- -- -- K12613 DCP2 mRNA-decapping enzyme subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12613 Q5REQ8 710 5.5e-73 m7GpppN-mRNA hydrolase OS=Pongo abelii GN=DCP2 PE=2 SV=1 PF00293//PF08273//PF15957//PF05026 NUDIX domain//Zinc-binding domain of primase-helicase//Commissureless//Dcp2, box A domain GO:0007411//GO:0006351//GO:0006269 axon guidance//transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0030145//GO:0016787//GO:0003896//GO:0004386//GO:0003723//GO:0008270 manganese ion binding//hydrolase activity//DNA primase activity//helicase activity//RNA binding//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2 Cluster-8309.42549 BF_2 75.27 0.41 7964 625256567 XP_007619640.1 744 2.8e-75 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like, partial [Cricetulus griseus] 642912444 XM_008202641.1 83 2.63391e-32 PREDICTED: Tribolium castaneum serum response factor (Srf), transcript variant X1, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 718 1.2e-73 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF00096//PF13465//PF07776//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.42550 BF_2 18.67 0.38 2318 478255733 ENN75942.1 1725 1.4e-189 hypothetical protein YQE_07477, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PFK1 789 2.0e-82 Zinc finger protein 598 OS=Danio rerio GN=znf598 PE=1 SV=2 PF05395//PF13639//PF00096//PF00097//PF08119 Protein phosphatase inhibitor 1/DARPP-32//Ring finger domain//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//Scorpion acidic alpha-KTx toxin family GO:0007165//GO:0009405//GO:0006810 signal transduction//pathogenesis//transport GO:0008270//GO:0046872//GO:0004864//GO:0019870//GO:0005515 zinc ion binding//metal ion binding//protein phosphatase inhibitor activity//potassium channel inhibitor activity//protein binding GO:0005576 extracellular region KOG2231 Predicted E3 ubiquitin ligase Cluster-8309.42551 BF_2 131.30 0.52 10764 642937913 XP_972695.3 1638 8.1e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.5e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42553 BF_2 619.77 4.08 6634 642917203 XP_008191162.1 5579 0.0e+00 PREDICTED: protein virilizer [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AIV2 848 8.3e-89 Protein virilizer homolog OS=Mus musculus GN=Kiaa1429 PE=1 SV=1 PF00665//PF01529 Integrase core domain//DHHC palmitoyltransferase GO:0015074 DNA integration GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.4256 BF_2 11.69 0.41 1493 189242300 XP_001811434.1 777 7.7e-80 PREDICTED: bone morphogenetic protein 7 [Tribolium castaneum]>gi|270015437|gb|EFA11885.1| maverick [Tribolium castaneum] -- -- -- -- -- K04384 TGFBN transforming growth factor beta, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K04384 P20722 183 2.4e-12 Bone morphogenetic protein 6 OS=Mus musculus GN=Bmp6 PE=1 SV=2 PF00019//PF00688 Transforming growth factor beta like domain//TGF-beta propeptide GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083 growth factor activity -- -- -- -- Cluster-8309.42560 BF_2 347.56 4.33 3647 478253263 ENN73634.1 2771 1.1e-310 hypothetical protein YQE_09881, partial [Dendroctonus ponderosae] -- -- -- -- -- K00771 XYLT protein xylosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00771 Q5QQ53 2068 1.6e-230 Xylosyltransferase oxt OS=Drosophila pseudoobscura pseudoobscura GN=oxt PE=2 SV=1 PF02485//PF12529 Core-2/I-Branching enzyme//Xylosyltransferase C terminal GO:0030206//GO:0006024 chondroitin sulfate biosynthetic process//glycosaminoglycan biosynthetic process GO:0030158//GO:0008375 protein xylosyltransferase activity//acetylglucosaminyltransferase activity GO:0016020 membrane KOG0799 Branching enzyme Cluster-8309.42561 BF_2 84.48 2.25 1857 332377013 AEE63646.1 1214 2.0e-130 unknown [Dendroctonus ponderosae]>gi|478253342|gb|ENN73703.1| hypothetical protein YQE_09700, partial [Dendroctonus ponderosae]>gi|546673935|gb|ERL85446.1| hypothetical protein D910_02865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0VD07 264 1.2e-21 Neuronal membrane glycoprotein M6-a OS=Bos taurus GN=GPM6A PE=2 SV=1 PF01275 Myelin proteolipid protein (PLP or lipophilin) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42563 BF_2 50.61 0.64 3579 546683891 ERL93639.1 657 1.5e-65 hypothetical protein D910_10927 [Dendroctonus ponderosae] -- -- -- -- -- K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 Q9NZR2 171 1.4e-10 Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens GN=LRP1B PE=1 SV=2 PF02723//PF00057//PF09788 Non-structural protein NS3/Small envelope protein E//Low-density lipoprotein receptor domain class A//Transmembrane protein 55A GO:0046856 phosphatidylinositol dephosphorylation GO:0034597//GO:0005515 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity//protein binding GO:0016020 membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.42564 BF_2 77.71 6.41 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42565 BF_2 862.76 19.38 2149 728416984 AIY68330.1 1408 7.6e-153 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 642 2.1e-65 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.42567 BF_2 798.69 9.72 3725 642923468 XP_008193757.1 632 1.3e-62 PREDICTED: glia maturation factor beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49858 457 1.0e-43 Protein cornichon OS=Drosophila melanogaster GN=cni PE=1 SV=1 PF00241//PF03311 Cofilin/tropomyosin-type actin-binding protein//Cornichon protein GO:0035556 intracellular signal transduction GO:0003779 actin binding GO:0016020//GO:0005622 membrane//intracellular KOG2729 ER vesicle integral membrane protein involved in establishing cell polarity, signaling and protein degradation Cluster-8309.42568 BF_2 73.49 6.10 791 478252109 ENN72540.1 517 5.8e-50 hypothetical protein YQE_10880, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02133 Permease for cytosine/purines, uracil, thiamine, allantoin GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.42570 BF_2 35.53 0.55 2979 189238377 XP_001808976.1 927 6.2e-97 PREDICTED: uncharacterized protein LOC100141756 [Tribolium castaneum]>gi|270008562|gb|EFA05010.1| hypothetical protein TcasGA2_TC015091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42571 BF_2 135.17 0.81 7269 642935386 XP_008197990.1 2226 3.6e-247 PREDICTED: histone acetyltransferase KAT7 [Tribolium castaneum] -- -- -- -- -- K11307 MYST2, HBO1, KAT7 histone acetyltransferase MYST2 http://www.genome.jp/dbget-bin/www_bget?ko:K11307 Q810T5 1269 1.4e-137 Histone acetyltransferase KAT7 OS=Rattus norvegicus GN=Kat7 PE=2 SV=1 PF01530//PF01853//PF13508 Zinc finger, C2HC type//MOZ/SAS family//Acetyltransferase (GNAT) domain GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0008080//GO:0003700//GO:0016747//GO:0008270 N-acetyltransferase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.42572 BF_2 45.60 1.98 1252 755893212 XP_011295172.1 147 7.3e-07 PREDICTED: uncharacterized protein LOC105262278 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42577 BF_2 3.00 0.83 438 607368123 EZA62240.1 141 1.3e-06 hypothetical protein X777_00608 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42578 BF_2 148.15 2.47 2800 780649216 XP_011689959.1 1310 2.3e-141 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.42581 BF_2 113.32 0.43 11203 270014366 EFA10814.1 2723 1.3e-304 hypothetical protein TcasGA2_TC030632 [Tribolium castaneum] 462321141 APGK01043373.1 66 1.04626e-22 Dendroctonus ponderosae Seq01043383, whole genome shotgun sequence K11984 SART1, HAF, SNU66 U4/U6.U5 tri-snRNP-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11984 O43290 908 1.5e-95 U4/U6.U5 tri-snRNP-associated protein 1 OS=Homo sapiens GN=SART1 PE=1 SV=1 PF00569//PF00856//PF00628//PF01033//PF03343//PF03412//PF07496 Zinc finger, ZZ type//SET domain//PHD-finger//Somatomedin B domain//SART-1 family//Peptidase C39 family//CW-type Zinc Finger GO:0006508//GO:0006955//GO:0000398//GO:0007165 proteolysis//immune response//mRNA splicing, via spliceosome//signal transduction GO:0008270//GO:0030247//GO:0008233//GO:0005524//GO:0005044//GO:0005515 zinc ion binding//polysaccharide binding//peptidase activity//ATP binding//scavenger receptor activity//protein binding GO:0016021 integral component of membrane KOG2217 U4/U6.U5 snRNP associated protein Cluster-8309.42582 BF_2 102.46 1.08 4258 642929562 XP_008195885.1 1287 1.6e-138 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] 642929561 XM_008197663.1 59 3.08087e-19 PREDICTED: Tribolium castaneum ankyrin repeat and IBR domain-containing protein 1-like (LOC664247), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42584 BF_2 272.18 3.95 3167 91085723 XP_973304.1 1054 1.2e-111 PREDICTED: [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial [Tribolium castaneum]>gi|270010109|gb|EFA06557.1| hypothetical protein TcasGA2_TC009468 [Tribolium castaneum] -- -- -- -- -- K00898 PDK2_3_4 pyruvate dehydrogenase kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K00898 P91622 713 1.8e-73 [Pyruvate dehydrogenase (acetyl-transferring)] kinase, mitochondrial OS=Drosophila melanogaster GN=Pdk PE=2 SV=2 PF00942 Cellulose binding domain GO:0005975 carbohydrate metabolic process GO:0005524//GO:0030248 ATP binding//cellulose binding -- -- KOG0787 Dehydrogenase kinase Cluster-8309.42585 BF_2 447.05 15.52 1492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42586 BF_2 325.95 3.88 3805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42587 BF_2 39.63 1.29 1573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42588 BF_2 228.38 3.11 3361 270001283 EEZ97730.1 2674 1.9e-299 stumps [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.9e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0005801//GO:0016020 cis-Golgi network//membrane -- -- Cluster-8309.42589 BF_2 1728.91 19.48 3999 91077584 XP_973097.1 4110 0.0e+00 PREDICTED: disintegrin and metalloproteinase domain-containing protein 10 [Tribolium castaneum] 817210687 XM_012426021.1 362 0 PREDICTED: Orussus abietinus disintegrin and metalloproteinase domain-containing protein 10 (LOC105700306), mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 O14672 1111 1.6e-119 Disintegrin and metalloproteinase domain-containing protein 10 OS=Homo sapiens GN=ADAM10 PE=1 SV=1 PF01562//PF01421 Reprolysin family propeptide//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.4259 BF_2 23.00 0.83 1453 478253177 ENN73548.1 260 6.7e-20 hypothetical protein YQE_09799, partial [Dendroctonus ponderosae]>gi|546678929|gb|ERL89467.1| hypothetical protein D910_06833 [Dendroctonus ponderosae] -- -- -- -- -- K15693 RNF26 RING finger protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K15693 Q8BUH7 177 1.2e-11 Ring finger protein 26 OS=Mus musculus GN=Rnf26 PE=2 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG4265 Predicted E3 ubiquitin ligase Cluster-8309.42590 BF_2 2445.97 23.02 4732 642933145 XP_008197275.1 2062 2.4e-228 PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum]>gi|642933147|ref|XP_008197277.1| PREDICTED: extracellular serine/threonine protein kinase FAM20C isoform X1 [Tribolium castaneum] 642933146 XM_008199055.1 284 2.87126e-144 PREDICTED: Tribolium castaneum extracellular serine/threonine protein kinase FAM20C (LOC662687), transcript variant X2, mRNA -- -- -- -- A4VCL2 1487 4.7e-163 Extracellular serine/threonine protein CG31145 OS=Drosophila melanogaster GN=CG31145 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3829 Uncharacterized conserved protein Cluster-8309.42592 BF_2 2145.17 26.11 3724 91091542 XP_970835.1 1754 9.9e-193 PREDICTED: retinal dehydrogenase 1 [Tribolium castaneum]>gi|270000922|gb|EEZ97369.1| hypothetical protein TcasGA2_TC011192 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 Q66HF8 1393 3.0e-152 Aldehyde dehydrogenase X, mitochondrial OS=Rattus norvegicus GN=Aldh1b1 PE=1 SV=1 PF00705//PF00171 Proliferating cell nuclear antigen, N-terminal domain//Aldehyde dehydrogenase family GO:0055114//GO:0008152//GO:0006275 oxidation-reduction process//metabolic process//regulation of DNA replication GO:0016491//GO:0016620//GO:0003677 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//DNA binding -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.42593 BF_2 902.97 9.82 4132 91092680 XP_971368.1 4473 0.0e+00 PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911362|ref|XP_008199390.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911364|ref|XP_008199391.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|642911366|ref|XP_008199393.1| PREDICTED: AP-2 complex subunit alpha [Tribolium castaneum]>gi|270014815|gb|EFA11263.1| hypothetical protein TcasGA2_TC010798 [Tribolium castaneum] 815809952 XM_012370439.1 590 0 PREDICTED: Linepithema humile AP-2 complex subunit alpha (LOC105674243), transcript variant X2, mRNA K11824 AP2A AP-2 complex subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K11824 Q7QG73 3987 0.0e+00 AP-2 complex subunit alpha OS=Anopheles gambiae GN=alpha-Adaptin PE=3 SV=4 PF09090//PF02985//PF02883//PF02296//PF01602 MIF4G like//HEAT repeat//Adaptin C-terminal domain//Alpha adaptin AP2, C-terminal domain//Adaptin N terminal region GO:0015031//GO:0016192//GO:0006886//GO:0016070 protein transport//vesicle-mediated transport//intracellular protein transport//RNA metabolic process GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0030117//GO:0030131 membrane coat//clathrin adaptor complex KOG1077 Vesicle coat complex AP-2, alpha subunit Cluster-8309.42594 BF_2 170.64 1.20 6222 91077030 XP_967400.1 1894 9.7e-209 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1086 2.0e-116 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF07714//PF03604//PF05028//PF01029//PF00069//PF06293//PF13971 Protein tyrosine kinase//DNA directed RNA polymerase, 7 kDa subunit//Poly (ADP-ribose) glycohydrolase (PARG)//NusB family//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Meiosis-specific protein Mei4 GO:0006144//GO:0006351//GO:0042138//GO:0006206//GO:0006310//GO:0006468//GO:0005975//GO:0006355 purine nucleobase metabolic process//transcription, DNA-templated//meiotic DNA double-strand break formation//pyrimidine nucleobase metabolic process//DNA recombination//protein phosphorylation//carbohydrate metabolic process//regulation of transcription, DNA-templated GO:0003677//GO:0003723//GO:0004649//GO:0004672//GO:0016773//GO:0003899//GO:0005524 DNA binding//RNA binding//poly(ADP-ribose) glycohydrolase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//DNA-directed RNA polymerase activity//ATP binding GO:0016020//GO:0005730 membrane//nucleolus KOG3087 Serine/threonine protein kinase Cluster-8309.42596 BF_2 167.21 4.63 1799 546685375 ERL94893.1 766 1.8e-78 hypothetical protein D910_12166 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09302 XLF-Cernunnos, XRcc4-like factor, NHEJ component GO:0006302 double-strand break repair -- -- GO:0005634 nucleus -- -- Cluster-8309.42598 BF_2 258.00 5.23 2350 91091730 XP_967397.1 826 2.5e-85 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270001070|gb|EEZ97517.1| hypothetical protein TcasGA2_TC011362 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.426 BF_2 12.00 19.11 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42600 BF_2 341.73 8.66 1937 642918045 XP_008198993.1 411 2.8e-37 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VII6 224 5.5e-17 Choline transporter-like protein 1 OS=Rattus norvegicus GN=Slc44a1 PE=1 SV=1 PF05786//PF00063 Condensin complex subunit 2//Myosin head (motor domain) GO:0007076 mitotic chromosome condensation GO:0005524//GO:0003774 ATP binding//motor activity GO:0000796//GO:0016459 condensin complex//myosin complex KOG1362 Choline transporter-like protein Cluster-8309.42604 BF_2 225.00 4.91 2204 501289832 BAN20095.1 635 3.3e-63 cathepsin L [Riptortus pedestris] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 594 7.8e-60 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF00112//PF03051//PF15163 Papain family cysteine protease//Peptidase C1-like family//Meiosis-expressed GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity GO:0005634 nucleus KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.42605 BF_2 27.91 0.48 2698 731275672 XP_010606850.1 276 1.7e-21 PREDICTED: macrophage mannose receptor 1-like [Fukomys damarensis]>gi|676265405|gb|KFO21624.1| Macrophage mannose receptor 1 [Fukomys damarensis] -- -- -- -- -- -- -- -- -- P82596 171 1.1e-10 Perlucin OS=Haliotis laevigata PE=1 SV=3 PF07740//PF02944 Ion channel inhibitory toxin//BESS motif GO:0009405//GO:0006810 pathogenesis//transport GO:0008200//GO:0003677 ion channel inhibitor activity//DNA binding GO:0005576 extracellular region -- -- Cluster-8309.42607 BF_2 272.27 2.60 4672 642919577 XP_008191928.1 3192 0.0e+00 PREDICTED: heat shock 70 kDa protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09485 HSP110 heat shock protein 110kDa http://www.genome.jp/dbget-bin/www_bget?ko:K09485 Q61316 1861 2.0e-206 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF02862//PF06723//PF04355 DDHD domain//MreB/Mbl protein//SmpA / OmlA family GO:0000902 cell morphogenesis GO:0046872 metal ion binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.42608 BF_2 2446.81 18.62 5783 189240885 XP_971484.2 5613 0.0e+00 PREDICTED: splicing factor 3B subunit 1 isoform X1 [Tribolium castaneum] 347963318 XM_310958.5 1205 0 Anopheles gambiae str. PEST AGAP000178-PA (AgaP_AGAP000178) mRNA, complete cds K12828 SF3B1, SAP155 splicing factor 3B subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12828 O75533 4878 0.0e+00 Splicing factor 3B subunit 1 OS=Homo sapiens GN=SF3B1 PE=1 SV=3 PF07571//PF04162//PF08064//PF04931//PF02985 TAF6 C-terminal HEAT repeat domain//Gyrovirus capsid protein (VP1)//UME (NUC010) domain//DNA polymerase phi//HEAT repeat GO:0006351//GO:0016310//GO:0051090//GO:0009069//GO:0006260 transcription, DNA-templated//phosphorylation//regulation of sequence-specific DNA binding transcription factor activity//serine family amino acid metabolic process//DNA replication GO:0003677//GO:0003887//GO:0005515//GO:0004674 DNA binding//DNA-directed DNA polymerase activity//protein binding//protein serine/threonine kinase activity GO:0019028//GO:0005634//GO:0042575 viral capsid//nucleus//DNA polymerase complex KOG0213 Splicing factor 3b, subunit 1 Cluster-8309.42610 BF_2 1035.08 9.93 4648 91080629 XP_974349.1 945 8.0e-99 PREDICTED: tetraspanin-9 [Tribolium castaneum]>gi|270005823|gb|EFA02271.1| hypothetical protein TcasGA2_TC007935 [Tribolium castaneum] 5628 X01518.1 48 4.38441e-13 Acyrthosiphon magnoliae (aphid) 5S ribosomal RNA K17350 TSPAN9 tetraspanin-9 http://www.genome.jp/dbget-bin/www_bget?ko:K17350 B0BM39 415 9.4e-39 Tetraspanin-9 OS=Xenopus tropicalis GN=tspan9 PE=2 SV=1 PF06687//PF00335//PF02949 SUR7/PalI family//Tetraspanin family//7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane -- -- Cluster-8309.42614 BF_2 45.00 2.10 1184 642915997 XP_008190849.1 672 9.2e-68 PREDICTED: nuclear anchorage protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2ASS6 162 5.2e-10 Titin OS=Mus musculus GN=Ttn PE=1 SV=1 PF15185//PF13895 Bcl-2-modifying factor, apoptosis//Immunoglobulin domain GO:0006915 apoptotic process GO:0005515 protein binding -- -- -- -- Cluster-8309.42615 BF_2 19.66 0.62 1608 91080851 XP_971681.1 511 5.8e-49 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 352 6.5e-32 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF00437//PF02421//PF00005//PF03193//PF01637//PF13304//PF01926 Type II/IV secretion system protein//Ferrous iron transport protein B//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase GO:0006200//GO:0006810//GO:0015684 obsolete ATP catabolic process//transport//ferrous iron transport GO:0005524//GO:0015093//GO:0003924//GO:0016887//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.42617 BF_2 256.00 4.40 2723 642918930 XP_008191661.1 1897 1.9e-209 PREDICTED: B-box type zinc finger protein ncl-1-like isoform X1 [Tribolium castaneum]>gi|642918932|ref|XP_008191662.1| PREDICTED: B-box type zinc finger protein ncl-1-like isoform X1 [Tribolium castaneum]>gi|642918934|ref|XP_008191663.1| PREDICTED: B-box type zinc finger protein ncl-1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64127 269 4.7e-22 Transcription intermediary factor 1-alpha OS=Mus musculus GN=Trim24 PE=1 SV=1 PF00097//PF14634//PF01363//PF00643//PF13639 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//FYVE zinc finger//B-box zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005622 intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.42619 BF_2 20.52 0.33 2889 332374366 AEE62324.1 456 2.5e-42 unknown [Dendroctonus ponderosae] 701373554 XM_009988747.1 54 1.25297e-16 PREDICTED: Tauraco erythrolophus DNA-damage inducible 1 homolog 2 (S. cerevisiae) (DDI2), partial mRNA K11885 DDI1 DNA damage-inducible protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11885 Q6TH22 295 4.8e-25 Protein DDI1 homolog 2 OS=Danio rerio GN=ddi2 PE=2 SV=1 PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- KOG0012 DNA damage inducible protein Cluster-8309.42620 BF_2 121.29 2.22 2575 546680966 ERL91140.1 559 2.5e-54 hypothetical protein D910_08480 [Dendroctonus ponderosae] 642937909 XM_008202132.1 89 3.90137e-36 PREDICTED: Tribolium castaneum zinc finger RNA-binding protein (LOC660269), mRNA K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q6PCR6 397 6.3e-37 Zinc finger RNA-binding protein OS=Danio rerio GN=zfr PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.42622 BF_2 43.64 0.48 4088 321462910 EFX73930.1 533 4.2e-51 hypothetical protein DAPPUDRAFT_307535 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q6UWB4 293 1.2e-24 Serine protease 55 OS=Homo sapiens GN=PRSS55 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.42623 BF_2 17.64 0.83 1176 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42625 BF_2 1332.00 14.95 4015 91079794 XP_966414.1 2188 5.1e-243 PREDICTED: tyrosine-protein kinase Src64B [Tribolium castaneum]>gi|642918199|ref|XP_008191407.1| PREDICTED: tyrosine-protein kinase Src64B [Tribolium castaneum] 158295963 XM_316537.3 333 1.40336e-171 Anopheles gambiae str. PEST AGAP006510-PA (AgaP_AGAP006510) mRNA, complete cds K05704 SRC tyrosine-protein kinase Src http://www.genome.jp/dbget-bin/www_bget?ko:K05704 P00528 1938 2.0e-215 Tyrosine-protein kinase Src64B OS=Drosophila melanogaster GN=Src64B PE=1 SV=3 PF07714//PF14604//PF00018//PF00069 Protein tyrosine kinase//Variant SH3 domain//SH3 domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0005515//GO:0004672 ATP binding//protein binding//protein kinase activity -- -- -- -- Cluster-8309.42626 BF_2 56.46 0.34 7196 91090320 XP_972446.1 2561 5.1e-286 PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|642934930|ref|XP_008197867.1| PREDICTED: rho-related BTB domain-containing protein 2 [Tribolium castaneum]>gi|270013809|gb|EFA10257.1| hypothetical protein TcasGA2_TC012457 [Tribolium castaneum] 642934932 XM_967353.2 685 0 PREDICTED: Tribolium castaneum rho-related BTB domain-containing protein 2 (LOC661174), transcript variant X3, mRNA K07868 RHOBTB1_2 Rho-related BTB domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K07868 Q9DAK3 906 1.7e-95 Rho-related BTB domain-containing protein 1 OS=Mus musculus GN=Rhobtb1 PE=1 SV=2 PF00651//PF08477//PF00071 BTB/POZ domain//Ras of Complex, Roc, domain of DAPkinase//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005515 GTP binding//protein binding GO:0005622 intracellular -- -- Cluster-8309.42627 BF_2 3291.00 65.59 2386 478253496 ENN73823.1 1643 4.7e-180 hypothetical protein YQE_09601, partial [Dendroctonus ponderosae]>gi|546679122|gb|ERL89627.1| hypothetical protein D910_06992 [Dendroctonus ponderosae] 642937401 XM_963712.3 458 0 PREDICTED: Tribolium castaneum innexin inx2 (LOC657243), mRNA -- -- -- -- Q9XYN1 1557 1.8e-171 Innexin inx2 OS=Schistocerca americana GN=inx2 PE=1 SV=1 PF00839//PF00876 Cysteine rich repeat//Innexin -- -- -- -- GO:0005921//GO:0016020 gap junction//membrane -- -- Cluster-8309.42628 BF_2 172.45 4.33 1954 728417130 AIY68334.1 1304 7.9e-141 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35502 596 4.0e-60 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.42629 BF_2 1052.69 5.44 8377 642923695 XP_008193847.1 5580 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1636 4.4e-180 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF03361//PF15723 Herpes virus intermediate/early protein 2/3//Motility quorum-sensing regulator, toxin of MqsA GO:0017148//GO:0042710//GO:0009372//GO:0006355 negative regulation of translation//biofilm formation//quorum sensing//regulation of transcription, DNA-templated -- -- -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.42630 BF_2 967.23 34.80 1450 91091412 XP_973980.1 450 6.2e-42 PREDICTED: cAMP-responsive element-binding protein-like 2 [Tribolium castaneum]>gi|270014172|gb|EFA10620.1| hypothetical protein TcasGA2_TC012882 [Tribolium castaneum] 751781411 XM_011201569.1 47 4.83962e-13 PREDICTED: Bactrocera dorsalis cAMP-responsive element-binding protein-like 2 (LOC105223754), mRNA -- -- -- -- A4IGK3 292 5.4e-25 cAMP-responsive element-binding protein-like 2 OS=Xenopus tropicalis GN=crebl2 PE=3 SV=1 PF00170//PF07716 bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42631 BF_2 40.58 0.40 4547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10729 Cell division activator CedA GO:0051301 cell division GO:0003677 DNA binding -- -- -- -- Cluster-8309.42633 BF_2 224.52 3.53 2951 642930769 XP_973375.2 3260 0.0e+00 PREDICTED: calpain-9-like [Tribolium castaneum] 662186924 XM_008486331.1 234 1.1113e-116 PREDICTED: Diaphorina citri calpain-3-like (LOC103521221), mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 O35920 971 2.0e-103 Calpain-9 OS=Rattus norvegicus GN=Capn9 PE=2 SV=2 PF00648//PF10403 Calpain family cysteine protease//Rad4 beta-hairpin domain 1 GO:0006508 proteolysis GO:0003677//GO:0004198 DNA binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.42634 BF_2 103.48 1.64 2934 642930769 XP_973375.2 3260 0.0e+00 PREDICTED: calpain-9-like [Tribolium castaneum] 662186924 XM_008486331.1 234 1.10482e-116 PREDICTED: Diaphorina citri calpain-3-like (LOC103521221), mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 O35920 971 2.0e-103 Calpain-9 OS=Rattus norvegicus GN=Capn9 PE=2 SV=2 PF00648//PF10403 Calpain family cysteine protease//Rad4 beta-hairpin domain 1 GO:0006508 proteolysis GO:0003677//GO:0004198 DNA binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.42635 BF_2 1155.29 26.50 2111 642934971 XP_008196003.1 1022 4.3e-108 PREDICTED: 205 kDa microtubule-associated protein-like [Tribolium castaneum] 642934970 XM_008197781.1 142 1.09919e-65 PREDICTED: Tribolium castaneum 205 kDa microtubule-associated protein-like (LOC656210), mRNA -- -- -- -- -- -- -- -- PF03872 Anti sigma-E protein RseA, N-terminal domain -- -- GO:0016989 sigma factor antagonist activity -- -- -- -- Cluster-8309.42636 BF_2 2.00 0.39 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42639 BF_2 35.84 0.42 3887 91081981 XP_968444.1 1743 1.9e-191 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921927|ref|XP_008192949.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921929|ref|XP_008192950.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007370|gb|EFA03818.1| hypothetical protein TcasGA2_TC013933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VMX0 787 5.7e-82 39S ribosomal protein L28, mitochondrial OS=Drosophila melanogaster GN=mRpL28 PE=2 SV=1 PF07690//PF00083//PF02568 Major Facilitator Superfamily//Sugar (and other) transporter//Thiamine biosynthesis protein (ThiI) GO:0055085//GO:0008033 transmembrane transport//tRNA processing GO:0022857//GO:0004810 transmembrane transporter activity//tRNA adenylyltransferase activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.42641 BF_2 1320.49 13.87 4270 91080723 XP_975387.1 919 7.6e-96 PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919596|ref|XP_008191933.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|642919599|ref|XP_008191934.1| PREDICTED: guanine nucleotide exchange factor for Rab-3A [Tribolium castaneum]>gi|270005868|gb|EFA02316.1| hypothetical protein TcasGA2_TC007982 [Tribolium castaneum] -- -- -- -- -- K16779 RAB3IP, RABIN8 Rab-3A-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K16779 Q2KJ58 289 3.5e-24 Guanine nucleotide exchange factor for Rab-3A OS=Bos taurus GN=RAB3IL1 PE=2 SV=1 PF02926//PF06008 THUMP domain//Laminin Domain I GO:0045995//GO:0007165//GO:0030155//GO:0030334 regulation of embryonic development//signal transduction//regulation of cell adhesion//regulation of cell migration GO:0005102//GO:0003723 receptor binding//RNA binding -- -- -- -- Cluster-8309.42643 BF_2 37.37 0.67 2606 270015294 EFA11742.1 455 2.9e-42 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01728//PF06689 FtsJ-like methyltransferase//ClpX C4-type zinc finger GO:0032259 methylation GO:0046983//GO:0008270//GO:0008168 protein dimerization activity//zinc ion binding//methyltransferase activity -- -- -- -- Cluster-8309.42645 BF_2 241.96 4.25 2668 642916256 XP_008190949.1 1280 6.5e-138 PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum]>gi|642916258|ref|XP_008190950.1| PREDICTED: uncharacterized protein LOC103312335 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08428 GPR139 G protein-coupled receptor 139 http://www.genome.jp/dbget-bin/www_bget?ko:K08428 Q9VZW5 219 2.9e-16 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.42647 BF_2 593.10 6.62 4037 646717218 KDR20164.1 788 1.1e-80 Heterogeneous nuclear ribonucleoprotein A1, A2/B1-like protein [Zootermopsis nevadensis] 780671672 XM_011697100.1 128 1.28362e-57 PREDICTED: Wasmannia auropunctata heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog (LOC105454481), mRNA K12741 HNRNPA1_3 heterogeneous nuclear ribonucleoprotein A1/A3 http://www.genome.jp/dbget-bin/www_bget?ko:K12741 P21522 704 2.5e-72 Heterogeneous nuclear ribonucleoprotein A1, A2/B1 homolog OS=Schistocerca americana GN=HNRNP PE=2 SV=1 PF00076//PF16367//PF00313 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//'Cold-shock' DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.42648 BF_2 62.20 0.47 5799 270003434 EEZ99881.1 5332 0.0e+00 hypothetical protein TcasGA2_TC002665 [Tribolium castaneum] 808141713 XM_012316967.1 60 1.16925e-19 PREDICTED: Bombus terrestris protein TANC2 (LOC100651021), transcript variant X3, mRNA -- -- -- -- Q9HCD6 2511 1.1e-281 Protein TANC2 OS=Homo sapiens GN=TANC2 PE=1 SV=3 PF13414//PF02376//PF00004//PF13606//PF01637//PF07728//PF00023 TPR repeat//CUT domain//ATPase family associated with various cellular activities (AAA)//Ankyrin repeat//Archaeal ATPase//AAA domain (dynein-related subfamily)//Ankyrin repeat -- -- GO:0016887//GO:0003677//GO:0005524//GO:0005515 ATPase activity//DNA binding//ATP binding//protein binding -- -- -- -- Cluster-8309.42649 BF_2 45.84 0.56 3713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42650 BF_2 867.00 15.45 2634 642923088 XP_972752.2 1457 1.9e-158 PREDICTED: hemocyte protein-glutamine gamma-glutamyltransferase [Tribolium castaneum] -- -- -- -- -- K03917 F13A1 coagulation factor XIII A1 polypeptide http://www.genome.jp/dbget-bin/www_bget?ko:K03917 Q05187 1119 1.2e-120 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00927//PF00868 Transglutaminase family, C-terminal ig like domain//Transglutaminase family GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.42651 BF_2 1157.58 5.46 9154 642922965 XP_008200471.1 8326 0.0e+00 PREDICTED: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1 [Tribolium castaneum] 642922966 XM_008202250.1 1408 0 PREDICTED: Tribolium castaneum probable ubiquitin carboxyl-terminal hydrolase FAF-X (LOC661487), transcript variant X2, mRNA K11840 USP9_24 ubiquitin carboxyl-terminal hydrolase 9/24 http://www.genome.jp/dbget-bin/www_bget?ko:K11840 Q93008 5006 0.0e+00 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Homo sapiens GN=USP9X PE=1 SV=3 PF11093//PF00443 Mitochondrial export protein Som1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG1866 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.42652 BF_2 2004.59 9.29 9311 642922965 XP_008200471.1 11133 0.0e+00 PREDICTED: probable ubiquitin carboxyl-terminal hydrolase FAF-X isoform X1 [Tribolium castaneum] 642922964 XM_008202249.1 1875 0 PREDICTED: Tribolium castaneum probable ubiquitin carboxyl-terminal hydrolase FAF-X (LOC661487), transcript variant X1, mRNA K11840 USP9_24 ubiquitin carboxyl-terminal hydrolase 9/24 http://www.genome.jp/dbget-bin/www_bget?ko:K11840 P70398 6863 0.0e+00 Probable ubiquitin carboxyl-terminal hydrolase FAF-X OS=Mus musculus GN=Usp9x PE=1 SV=2 PF11093//PF00443 Mitochondrial export protein Som1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity GO:0042720 mitochondrial inner membrane peptidase complex KOG1866 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.42654 BF_2 1.00 23.57 213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42657 BF_2 4364.77 40.41 4805 642918923 XP_008191658.1 5223 0.0e+00 PREDICTED: pyruvate carboxylase, mitochondrial isoform X1 [Tribolium castaneum] 817070062 XM_012401613.1 189 1.88357e-91 PREDICTED: Athalia rosae pyruvate carboxylase, mitochondrial (LOC105686618), transcript variant X3, mRNA K01958 PC, pyc pyruvate carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01958 Q29RK2 4044 0.0e+00 Pyruvate carboxylase, mitochondrial OS=Bos taurus GN=PC PE=2 SV=2 PF07478//PF02786//PF02655//PF05896//PF00682 D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//ATP-grasp domain//Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//HMGL-like GO:0009252//GO:0055114//GO:0006118//GO:0006814//GO:0046436 peptidoglycan biosynthetic process//oxidation-reduction process//obsolete electron transport//sodium ion transport//D-alanine metabolic process GO:0046872//GO:0016655//GO:0008716//GO:0005524//GO:0003824 metal ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//D-alanine-D-alanine ligase activity//ATP binding//catalytic activity -- -- KOG0369 Pyruvate carboxylase Cluster-8309.42660 BF_2 71.77 0.85 3827 827556941 XP_012549781.1 1539 8.7e-168 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42661 BF_2 157.89 2.82 2631 642918049 XP_008198995.1 2146 2.5e-238 PREDICTED: ATP-dependent RNA helicase dbp2-like [Tribolium castaneum] 805818946 XM_012294241.1 266 1.61039e-134 PREDICTED: Megachile rotundata probable ATP-dependent RNA helicase DDX17 (LOC100881729), transcript variant X7, mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1687 1.7e-186 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.42663 BF_2 6.01 0.33 1042 766928720 XP_011496419.1 298 1.9e-24 PREDICTED: dihydrofolate reductase [Ceratosolen solmsi marchali] 389612312 AK403254.1 35 1.6159e-06 Papilio xuthus mRNA for dihydrofolate reductase, partial cds, sequence id: Px-1353, expressed in epidermis K00287 folA dihydrofolate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00287 P04753 229 7.8e-18 Dihydrofolate reductase OS=Mesocricetus auratus GN=DHFR PE=2 SV=4 PF00186 Dihydrofolate reductase GO:0006761//GO:0046656//GO:0009165//GO:0055114//GO:0006545 dihydrofolate biosynthetic process//folic acid biosynthetic process//nucleotide biosynthetic process//oxidation-reduction process//glycine biosynthetic process GO:0004146 dihydrofolate reductase activity -- -- KOG1324 Dihydrofolate reductase Cluster-8309.42665 BF_2 17.80 1.28 869 642921394 XP_008192849.1 424 3.8e-39 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270006281|gb|EFA02729.1| hypothetical protein TcasGA2_TC008454 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 P45844 268 1.9e-22 ATP-binding cassette sub-family G member 1 OS=Homo sapiens GN=ABCG1 PE=1 SV=3 PF03193//PF00005//PF13304//PF01926//PF01637//PF02224 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Archaeal ATPase//Cytidylate kinase GO:0006139//GO:0006200//GO:0006206 nucleobase-containing compound metabolic process//obsolete ATP catabolic process//pyrimidine nucleobase metabolic process GO:0005524//GO:0003924//GO:0004127//GO:0016887//GO:0005525 ATP binding//GTPase activity//cytidylate kinase activity//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.42666 BF_2 29.13 0.80 1811 646705747 KDR13306.1 534 1.4e-51 Aldehyde dehydrogenase family 3 member B1, partial [Zootermopsis nevadensis] -- -- -- -- -- K00129 E1.2.1.5 aldehyde dehydrogenase (NAD(P)+) http://www.genome.jp/dbget-bin/www_bget?ko:K00129 Q5XI42 458 3.8e-44 Aldehyde dehydrogenase family 3 member B1 OS=Rattus norvegicus GN=Aldh3b1 PE=2 SV=1 PF00389//PF00171 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Aldehyde dehydrogenase family GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0051287//GO:0016616 oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.42669 BF_2 165.26 2.01 3724 242005288 XP_002423502.1 747 5.8e-76 beat protein, putative [Pediculus humanus corporis]>gi|212506606|gb|EEB10764.1| beat protein, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895//PF15339 Immunoglobulin domain//Acrosome formation-associated factor GO:0006897//GO:0007342//GO:0060478 endocytosis//fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis GO:0005515 protein binding GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8309.42670 BF_2 174.14 2.74 2949 260783431 XP_002586778.1 587 1.6e-57 hypothetical protein BRAFLDRAFT_102936 [Branchiostoma floridae]>gi|229271904|gb|EEN42789.1| hypothetical protein BRAFLDRAFT_102936 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q03938 398 5.6e-37 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF00096//PF13465//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.42671 BF_2 495.59 6.52 3467 91082257 XP_973105.1 1522 7.4e-166 PREDICTED: signal transducing adapter molecule 2 [Tribolium castaneum]>gi|270007457|gb|EFA03905.1| hypothetical protein TcasGA2_TC014037 [Tribolium castaneum] -- -- -- -- -- K04705 STAM signal transducing adaptor molecule http://www.genome.jp/dbget-bin/www_bget?ko:K04705 Q92783 870 1.2e-91 Signal transducing adapter molecule 1 OS=Homo sapiens GN=STAM PE=1 SV=3 PF00790//PF03127//PF14604//PF00018 VHS domain//GAT domain//Variant SH3 domain//SH3 domain GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0005622 intracellular KOG2199 Signal transducing adaptor protein STAM/STAM2 Cluster-8309.42673 BF_2 648.51 65.87 699 270007898 EFA04346.1 784 5.6e-81 hypothetical protein TcasGA2_TC014642 [Tribolium castaneum] -- -- -- -- -- K16600 TTLL2 tubulin polyglutamylase TTLL2 http://www.genome.jp/dbget-bin/www_bget?ko:K16600 Q9BWV7 297 6.8e-26 Probable tubulin polyglutamylase TTLL2 OS=Homo sapiens GN=TTLL2 PE=5 SV=3 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- -- -- Cluster-8309.42674 BF_2 11.00 2.66 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42675 BF_2 922.33 9.05 4549 270007804 EFA04252.1 2632 1.9e-294 hypothetical protein TcasGA2_TC014542 [Tribolium castaneum] 831223259 XM_012804206.1 235 4.78365e-117 PREDICTED: Otolemur garnettii RAN binding protein 9 (RANBP9), mRNA -- -- -- -- Q96S59 1739 2.7e-192 Ran-binding protein 9 OS=Homo sapiens GN=RANBP9 PE=1 SV=1 PF00622//PF06005//PF07557//PF08513//PF04977//PF07989//PF17122 SPRY domain//Protein of unknown function (DUF904)//Shugoshin C terminus//LisH//Septum formation initiator//Centrosomin N-terminal motif 1//Zinc-finger GO:0045132//GO:0043093//GO:0000917//GO:0007049 meiotic chromosome segregation//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634//GO:0005815//GO:0000775//GO:0005737 nucleus//microtubule organizing center//chromosome, centromeric region//cytoplasm KOG1477 SPRY domain-containing proteins Cluster-8309.42676 BF_2 15.00 13.90 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42678 BF_2 133.16 1.11 5318 642921981 XP_008192968.1 2698 4.9e-302 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8NFZ3 776 1.5e-80 Neuroligin-4, Y-linked OS=Homo sapiens GN=NLGN4Y PE=2 SV=1 PF06330//PF07859 Trichodiene synthase (TRI5)//alpha/beta hydrolase fold GO:0016106//GO:0016114//GO:0008152 sesquiterpenoid biosynthetic process//terpenoid biosynthetic process//metabolic process GO:0045482//GO:0016787 trichodiene synthase activity//hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.42679 BF_2 231.92 1.93 5306 642921981 XP_008192968.1 2946 0.0e+00 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 891 6.8e-94 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF06330//PF07859 Trichodiene synthase (TRI5)//alpha/beta hydrolase fold GO:0008152//GO:0016114//GO:0016106 metabolic process//terpenoid biosynthetic process//sesquiterpenoid biosynthetic process GO:0016787//GO:0045482 hydrolase activity//trichodiene synthase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.42681 BF_2 45.21 1.06 2066 546677470 ERL88302.1 1949 1.3e-215 hypothetical protein D910_05689 [Dendroctonus ponderosae] 642912507 XM_966689.2 445 0 PREDICTED: Tribolium castaneum cyclin dependent kinase 8 (LOC660461), mRNA K02208 CDK8_11 cyclin-dependent kinase 8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K02208 Q17IE8 1791 1.2e-198 Cyclin-dependent kinase 8 OS=Aedes aegypti GN=Cdk8 PE=3 SV=2 PF02932//PF00069//PF04973//PF02724//PF07714//PF06213 Neurotransmitter-gated ion-channel transmembrane region//Protein kinase domain//Nicotinamide mononucleotide transporter//CDC45-like protein//Protein tyrosine kinase//Cobalamin biosynthesis protein CobT GO:0006811//GO:0009236//GO:0034258//GO:0006270//GO:0006468 ion transport//cobalamin biosynthetic process//nicotinamide riboside transport//DNA replication initiation//protein phosphorylation GO:0004672//GO:0034257//GO:0005524 protein kinase activity//nicotinamide riboside transmembrane transporter activity//ATP binding GO:0016020 membrane KOG0666 Cyclin C-dependent kinase CDK8 Cluster-8309.42682 BF_2 7.00 2.03 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42683 BF_2 12.91 0.48 1404 641649259 XP_008185329.1 145 1.4e-06 PREDICTED: uncharacterized protein LOC100573760 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05933//PF06667 Fungal ATP synthase protein 8 (A6L)//Phage shock protein B GO:0015992//GO:0006355//GO:0015986//GO:0009271 proton transport//regulation of transcription, DNA-templated//ATP synthesis coupled proton transport//phage shock GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.42684 BF_2 65.03 0.62 4656 642915296 XP_008190559.1 391 1.4e-34 PREDICTED: signal recognition particle 9 kDa protein [Tribolium castaneum]>gi|270004979|gb|EFA01427.1| hypothetical protein TcasGA2_TC030568 [Tribolium castaneum] -- -- -- -- -- K03109 SRP9 signal recognition particle subunit SRP9 http://www.genome.jp/dbget-bin/www_bget?ko:K03109 Q9VSC1 231 2.0e-17 Signal recognition particle 9 kDa protein OS=Drosophila melanogaster GN=Srp9 PE=3 SV=1 -- -- GO:0006614//GO:0045900 SRP-dependent cotranslational protein targeting to membrane//negative regulation of translational elongation GO:0008312 7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3465 Signal recognition particle, subunit Srp9 Cluster-8309.42685 BF_2 16.96 0.70 1302 641649259 XP_008185329.1 145 1.3e-06 PREDICTED: uncharacterized protein LOC100573760 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667//PF05933 Phage shock protein B//Fungal ATP synthase protein 8 (A6L) GO:0006355//GO:0009271//GO:0015986//GO:0015992 regulation of transcription, DNA-templated//phage shock//ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.42686 BF_2 199.40 1.74 5069 642922756 XP_008193311.1 2454 9.1e-274 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|642922758|ref|XP_008193312.1| PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X1 [Tribolium castaneum] 751220523 XM_011165095.1 223 2.49968e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 1040 3.4e-111 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF00951//PF13895//PF00849 Arterivirus GL envelope glycoprotein//Immunoglobulin domain//RNA pseudouridylate synthase GO:0001522//GO:0009451 pseudouridine synthesis//RNA modification GO:0005515//GO:0003723//GO:0009982 protein binding//RNA binding//pseudouridine synthase activity GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.42688 BF_2 125.00 9.78 822 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42689 BF_2 678.13 4.14 7131 91077046 XP_968112.1 1016 7.1e-107 PREDICTED: ras-related C3 botulinum toxin substrate 1 [Tribolium castaneum]>gi|270002813|gb|EEZ99260.1| Mig-2-like protein [Tribolium castaneum] 746848885 XM_011056563.1 186 1.30316e-89 PREDICTED: Acromyrmex echinatior ras-related C3 botulinum toxin substrate 1 (LOC105146367), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 Q6RUV5 770 9.9e-80 Ras-related C3 botulinum toxin substrate 1 OS=Rattus norvegicus GN=Rac1 PE=1 SV=1 PF08477//PF05656//PF01501//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function (DUF805)//Glycosyl transferase family 8//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0016757//GO:0005525 transferase activity, transferring glycosyl groups//GTP binding GO:0005622//GO:0016020//GO:0016021 intracellular//membrane//integral component of membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.42690 BF_2 242.32 1.59 6665 512885476 XP_004921601.1 4075 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ATP-dependent RNA helicase DHX8 [Bombyx mori] 817212638 XM_012427088.1 642 0 PREDICTED: Orussus abietinus ATP-dependent RNA helicase DHX8 (LOC105700863), mRNA K12818 DHX8, PRP22 ATP-dependent RNA helicase DHX8/PRP22 http://www.genome.jp/dbget-bin/www_bget?ko:K12818 A2A4P0 3623 0.0e+00 ATP-dependent RNA helicase DHX8 OS=Mus musculus GN=Dhx8 PE=2 SV=1 PF07652//PF00437//PF00270//PF14532//PF00005//PF00575//PF04408 Flavivirus DEAD domain//Type II/IV secretion system protein//DEAD/DEAH box helicase//Sigma-54 interaction domain//ABC transporter//S1 RNA binding domain//Helicase associated domain (HA2) GO:0006355//GO:0019079//GO:0006810 regulation of transcription, DNA-templated//viral genome replication//transport GO:0003676//GO:0016887//GO:0005524//GO:0004386//GO:0008134//GO:0008026 nucleic acid binding//ATPase activity//ATP binding//helicase activity//transcription factor binding//ATP-dependent helicase activity GO:0005667 transcription factor complex KOG0922 DEAH-box RNA helicase Cluster-8309.42691 BF_2 56.87 0.61 4201 823397613 XP_012412169.1 386 4.8e-34 PREDICTED: macrophage mannose receptor 1 [Trichechus manatus latirostris] -- -- -- -- -- -- -- -- -- P22897 349 3.8e-31 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF04805//PF07840 E10-like protein conserved region//FadR C-terminal domain GO:0019217//GO:0055114 regulation of fatty acid metabolic process//oxidation-reduction process GO:0000062//GO:0016972 fatty-acyl-CoA binding//thiol oxidase activity -- -- KOG4297 C-type lectin Cluster-8309.42693 BF_2 1.00 1.43 300 260810234 XP_002599908.1 186 5.2e-12 hypothetical protein BRAFLDRAFT_58115 [Branchiostoma floridae]>gi|229285192|gb|EEN55920.1| hypothetical protein BRAFLDRAFT_58115 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P52746 143 2.1e-08 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF00301//PF07649//PF04988//PF13465//PF00096//PF06397//PF02150 Rubredoxin//C1-like domain//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type//Desulfoferrodoxin, N-terminal domain//RNA polymerases M/15 Kd subunit GO:0055114//GO:0006206//GO:0006144//GO:0006351 oxidation-reduction process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0047134//GO:0046872//GO:0005506//GO:0003899//GO:0003677 protein-disulfide reductase activity//metal ion binding//iron ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.42695 BF_2 6.00 1.84 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42696 BF_2 10.00 1.27 617 514683686 XP_004989424.1 181 4.1e-11 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- Q86Y25 143 4.3e-08 Zinc finger protein 354C OS=Homo sapiens GN=ZNF354C PE=2 SV=1 PF01146//PF00096//PF13465 Caveolin//Zinc finger, C2H2 type//Zinc-finger double domain GO:0070836 caveola assembly GO:0046872 metal ion binding -- -- -- -- Cluster-8309.42697 BF_2 8.00 0.48 978 514683686 XP_004989424.1 330 3.4e-28 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- Q13127 232 3.3e-18 RE1-silencing transcription factor OS=Homo sapiens GN=REST PE=1 SV=3 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.42698 BF_2 4.00 0.31 832 260823164 XP_002604053.1 192 2.9e-12 hypothetical protein BRAFLDRAFT_119781 [Branchiostoma floridae]>gi|229289378|gb|EEN60064.1| hypothetical protein BRAFLDRAFT_119781 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q642B9 136 3.8e-07 Zinc finger protein 18 OS=Rattus norvegicus GN=Znf18 PE=2 SV=1 PF02918//PF15036//PF00096//PF13465 Pertussis toxin, subunit 2 and 3, C-terminal domain//Interleukin 34//Zinc finger, C2H2 type//Zinc-finger double domain GO:0008284//GO:0001934//GO:0007165//GO:0009405//GO:0040007//GO:0008283 positive regulation of cell proliferation//positive regulation of protein phosphorylation//signal transduction//pathogenesis//growth//cell proliferation GO:0005157//GO:0046872 macrophage colony-stimulating factor receptor binding//metal ion binding GO:0005576//GO:0005615 extracellular region//extracellular space -- -- Cluster-8309.42701 BF_2 7.56 0.69 743 514683686 XP_004989424.1 263 1.5e-20 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- O54963 200 1.3e-14 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF00096//PF13465//PF04988 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95) -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding GO:0005634 nucleus KOG1721 FOG: Zn-finger Cluster-8309.42702 BF_2 2375.87 14.37 7205 546684210 ERL93915.1 1855 3.7e-204 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 119 2.31527e-52 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1311 1.8e-142 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF01105//PF00614//PF00412 emp24/gp25L/p24 family/GOLD//Phospholipase D Active site motif//LIM domain GO:0006810 transport GO:0003824//GO:0008270 catalytic activity//zinc ion binding GO:0016021 integral component of membrane KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.42703 BF_2 587.00 11.36 2448 270009982 EFA06430.1 1027 1.3e-108 hypothetical protein TcasGA2_TC009310 [Tribolium castaneum] -- -- -- -- -- K14689 SLC30A2, ZNT2 solute carrier family 30 (zinc transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14689 Q2HJ10 661 1.5e-67 Zinc transporter 2 OS=Mus musculus GN=Slc30a2 PE=2 SV=1 PF01545//PF12822 Cation efflux family//Protein of unknown function (DUF3816) GO:0055085//GO:0006812//GO:0006810 transmembrane transport//cation transport//transport GO:0008324//GO:0005215 cation transmembrane transporter activity//transporter activity GO:0016021 integral component of membrane KOG1482 Zn2+ transporter Cluster-8309.42705 BF_2 80.66 4.44 1047 642930472 XP_008196416.1 652 1.7e-65 PREDICTED: LOW QUALITY PROTEIN: papilin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q868Z9 561 2.5e-56 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.42706 BF_2 115.67 0.61 8231 642929799 XP_008195982.1 2636 1.2e-294 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 2-like [Tribolium castaneum] 118150627 NM_001077805.1 77 5.89346e-29 Danio rerio oxysterol binding protein-like 9 (osbpl9), mRNA >gnl|BL_ORD_ID|3545007 Danio rerio oxysterol binding protein-like 9, mRNA (cDNA clone MGC:154069 IMAGE:8338829), complete cds -- -- -- -- Q0IJ05 1433 1.5e-156 Oxysterol-binding protein-related protein 9 OS=Xenopus tropicalis GN=osbpl9 PE=2 SV=1 PF01421//PF05093//PF01562//PF10462//PF00413 Reprolysin (M12B) family zinc metalloprotease//Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis//Reprolysin family propeptide//Peptidase M66//Matrixin GO:0006508//GO:0016226 proteolysis//iron-sulfur cluster assembly GO:0004222//GO:0008270//GO:0051536 metalloendopeptidase activity//zinc ion binding//iron-sulfur cluster binding GO:0005737//GO:0031012 cytoplasm//extracellular matrix KOG2210 Oxysterol-binding protein Cluster-8309.42708 BF_2 1382.52 20.52 3105 642925798 XP_008190328.1 1995 9.4e-221 PREDICTED: protein PAT1 homolog 1 [Tribolium castaneum] 642925797 XM_008192106.1 59 2.23951e-19 PREDICTED: Tribolium castaneum protein PAT1 homolog 1 (LOC100142489), mRNA -- -- -- -- B5DF93 310 9.4e-27 Protein PAT1 homolog 1 OS=Rattus norvegicus GN=Patl1 PE=2 SV=1 PF12558 ATP-binding cassette cobalt transporter -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances -- -- -- -- Cluster-8309.42709 BF_2 527.00 18.75 1463 642919707 XP_008192031.1 782 2.0e-80 PREDICTED: cleavage and polyadenylation specificity factor subunit CG7185 [Tribolium castaneum] -- -- -- -- -- K14398 CPSF6_7 cleavage and polyadenylation specificity factor subunit 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K14398 Q9VSH4 418 1.3e-39 Cleavage and polyadenylation specificity factor subunit CG7185 OS=Drosophila melanogaster GN=CG7185 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4849 mRNA cleavage factor I subunit/CPSF subunit Cluster-8309.4271 BF_2 18.27 0.57 1629 91087945 XP_972135.1 1136 2.0e-121 PREDICTED: CUE domain-containing protein 2 [Tribolium castaneum]>gi|270011934|gb|EFA08382.1| hypothetical protein TcasGA2_TC006025 [Tribolium castaneum] 642930958 XM_967042.2 295 7.48347e-151 PREDICTED: Tribolium castaneum CUE domain-containing protein 2 (LOC660839), mRNA -- -- -- -- Q6TLH3 407 2.8e-38 CUE domain-containing protein 2 OS=Danio rerio GN=cuedc2 PE=2 SV=1 PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42711 BF_2 1385.10 19.32 3286 646724140 KDR24501.1 2122 1.9e-235 BTB/POZ domain-containing protein 3 [Zootermopsis nevadensis] 560970175 XM_006207391.1 80 5.02578e-31 PREDICTED: Vicugna pacos BTB (POZ) domain containing 3 (BTBD3), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 1671 1.5e-184 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.42712 BF_2 748.23 2.91 11042 642934936 XP_008195867.1 3146 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 5.54187e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 548 8.4e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05197//PF05225 TRIC channel//helix-turn-helix, Psq domain GO:0006812//GO:0015672 cation transport//monovalent inorganic cation transport GO:0005261//GO:0003677 cation channel activity//DNA binding GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.42713 BF_2 194.62 0.75 11071 642934936 XP_008195867.1 3146 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 5.55647e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 548 8.5e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05197//PF05225 TRIC channel//helix-turn-helix, Psq domain GO:0006812//GO:0015672 cation transport//monovalent inorganic cation transport GO:0005261//GO:0003677 cation channel activity//DNA binding GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.42715 BF_2 65.83 0.36 7976 270011776 EFA08224.1 1024 9.4e-108 hypothetical protein TcasGA2_TC005851 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q0VCL9 362 2.3e-32 Uncharacterized protein C3orf38 homolog OS=Bos taurus PE=2 SV=2 PF17123//PF10204//PF00651//PF00096//PF01283//PF04062 RING-like zinc finger//Dual oxidase maturation factor//BTB/POZ domain//Zinc finger, C2H2 type//Ribosomal protein S26e//ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0006412//GO:0034314//GO:0015031//GO:0042254 regulation of actin filament polymerization//translation//Arp2/3 complex-mediated actin nucleation//protein transport//ribosome biogenesis GO:0005515//GO:0003735//GO:0008270//GO:0046872 protein binding//structural constituent of ribosome//zinc ion binding//metal ion binding GO:0005856//GO:0005789//GO:0016021//GO:0005885//GO:0005622//GO:0005840 cytoskeleton//endoplasmic reticulum membrane//integral component of membrane//Arp2/3 protein complex//intracellular//ribosome -- -- Cluster-8309.42716 BF_2 208.12 2.02 4597 350414142 XP_003490218.1 2832 0.0e+00 PREDICTED: protein O-GlcNAcase isoform X3 [Bombus impatiens] 830022072 XM_012723671.1 44 7.25554e-11 PREDICTED: Condylura cristata meningioma expressed antigen 5 (hyaluronidase) (MGEA5), transcript variant X2, mRNA K15719 NCOAT, MGEA5 protein O-GlcNAcase / histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15719 O60502 1092 2.9e-117 Protein O-GlcNAcase OS=Homo sapiens GN=MGEA5 PE=1 SV=2 PF05418//PF00736 Apovitellenin I (Apo-VLDL-II)//EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006629//GO:0006448 translational elongation//lipid metabolic process//regulation of translational elongation GO:0003746//GO:0004857 translation elongation factor activity//enzyme inhibitor activity GO:0005853//GO:0005840//GO:0042627 eukaryotic translation elongation factor 1 complex//ribosome//chylomicron KOG3698 Hyaluronoglucosaminidase Cluster-8309.42717 BF_2 615.00 4.63 5844 642910543 XP_008200257.1 3897 0.0e+00 PREDICTED: zinc finger MYM-type protein 3 isoform X1 [Tribolium castaneum] 462332881 APGK01039173.1 211 1.3516e-103 Dendroctonus ponderosae Seq01039183, whole genome shotgun sequence -- -- -- -- Q9JLM4 734 1.2e-75 Zinc finger MYM-type protein 3 OS=Mus musculus GN=Zmym3 PE=2 SV=1 PF06467//PF08140 MYM-type Zinc finger with FCS sequence motif//Crustacean cuticle protein repeat -- -- GO:0008270//GO:0042302 zinc ion binding//structural constituent of cuticle -- -- -- -- Cluster-8309.42718 BF_2 240.06 5.01 2293 646682520 KDR02319.1 1568 2.3e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 2.6622e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.1e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF00069//PF07714//PF00937 Protein kinase domain//Protein tyrosine kinase//Coronavirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.42719 BF_2 94.06 0.87 4790 642910776 XP_008193405.1 2380 3.3e-265 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 3.37229e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1134 4.1e-122 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.42720 BF_2 560.76 2.95 8233 642913878 XP_975183.2 4525 0.0e+00 PREDICTED: uncharacterized protein LOC664073 isoform X1 [Tribolium castaneum] 462334568 APGK01038534.1 105 1.60458e-44 Dendroctonus ponderosae Seq01038544, whole genome shotgun sequence K17598 SYTL synaptotagmin-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17598 Q96C24 760 1.6e-78 Synaptotagmin-like protein 4 OS=Homo sapiens GN=SYTL4 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.42722 BF_2 2178.00 29.85 3339 478260891 ENN80525.1 598 9.9e-59 hypothetical protein YQE_03054, partial [Dendroctonus ponderosae]>gi|478265306|gb|ENN82461.1| hypothetical protein YQE_01164, partial [Dendroctonus ponderosae]>gi|478265308|gb|ENN82462.1| hypothetical protein YQE_01163, partial [Dendroctonus ponderosae]>gi|546683001|gb|ERL92873.1| hypothetical protein D910_10179 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00198//PF03145 2-oxoacid dehydrogenases acyltransferase (catalytic domain)//Seven in absentia protein family GO:0007275//GO:0008152//GO:0006511 multicellular organismal development//metabolic process//ubiquitin-dependent protein catabolic process GO:0016746 transferase activity, transferring acyl groups GO:0005634 nucleus -- -- Cluster-8309.42724 BF_2 43.12 1.24 1745 642919181 XP_008191771.1 737 3.9e-75 PREDICTED: uncharacterized protein LOC103312580 isoform X1 [Tribolium castaneum]>gi|270005582|gb|EFA02030.1| hypothetical protein TcasGA2_TC007655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42725 BF_2 4040.43 39.39 4578 197276682 NP_001127850.1 1395 5.2e-151 smoothened precursor [Tribolium castaneum]>gi|270012713|gb|EFA09161.1| smoothened [Tribolium castaneum] 645012677 XM_001604820.3 303 7.6129e-155 PREDICTED: Nasonia vitripennis uncharacterized LOC100119467 (LOC100119467), mRNA -- -- -- -- P91682 670 2.5e-68 Protein smoothened OS=Drosophila melanogaster GN=smo PE=1 SV=1 PF01534 Frizzled/Smoothened family membrane region GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.42728 BF_2 31.50 0.65 2318 642926703 XP_970920.2 302 1.4e-24 PREDICTED: uncharacterized protein LOC659528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 213 1.2e-15 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42732 BF_2 19.18 0.34 2639 642919618 XP_008191942.1 572 8.1e-56 PREDICTED: protein kinase C and casein kinase substrate in neurons protein 1 [Tribolium castaneum]>gi|270005457|gb|EFA01905.1| hypothetical protein TcasGA2_TC007515 [Tribolium castaneum] 642919617 XM_008193720.1 76 6.74039e-29 PREDICTED: Tribolium castaneum protein kinase C and casein kinase substrate in neurons protein 1 (LOC103312632), mRNA -- -- -- -- Q9DDA9 294 5.7e-25 Protein kinase C and casein kinase substrate in neurons protein 2 OS=Xenopus laevis GN=pacsin2 PE=2 SV=1 PF03947//PF01786//PF15460 Ribosomal Proteins L2, C-terminal domain//Alternative oxidase//Something about silencing, SAS, complex subunit 4 GO:0006412//GO:0016573//GO:0055114//GO:0042254//GO:0006118 translation//histone acetylation//oxidation-reduction process//ribosome biogenesis//obsolete electron transport GO:0009916//GO:0003735 alternative oxidase activity//structural constituent of ribosome GO:0005840 ribosome KOG2856 Adaptor protein PACSIN Cluster-8309.42735 BF_2 56.09 0.80 3203 478257125 ENN77288.1 488 5.4e-46 hypothetical protein YQE_06114, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P5B9 244 4.4e-19 Ankyrin repeat domain-containing protein 39 OS=Bos taurus GN=ANKRD39 PE=2 SV=1 PF13606//PF06399//PF00023 Ankyrin repeat//GTP cyclohydrolase I feedback regulatory protein (GFRP)//Ankyrin repeat GO:0009890 negative regulation of biosynthetic process GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.42736 BF_2 23.99 1.64 898 642913015 XP_008201353.1 572 2.7e-56 PREDICTED: spectrin alpha chain [Tribolium castaneum]>gi|270002786|gb|EEZ99233.1| alpha spectrin [Tribolium castaneum] 768429654 XM_011557714.1 143 1.27233e-66 PREDICTED: Plutella xylostella spectrin alpha chain-like (LOC105387044), mRNA K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 536 1.7e-53 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF13202//PF13499//PF13405//PF10591//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.42737 BF_2 36.82 0.43 3878 -- -- -- -- -- 462302759 APGK01050095.1 54 1.68732e-16 Dendroctonus ponderosae Seq01050105, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42739 BF_2 2680.73 13.22 8770 642920269 XP_008192276.1 3095 0.0e+00 PREDICTED: anoctamin-1-like isoform X2 [Tribolium castaneum] 780682419 XM_011699543.1 39 8.35836e-08 PREDICTED: Wasmannia auropunctata anoctamin-1 (LOC105455869), transcript variant X4, mRNA K19496 ANO1, DOG1, TMEM16A anoctamin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19496 Q8BHY3 1545 1.6e-169 Anoctamin-1 OS=Mus musculus GN=Ano1 PE=1 SV=2 PF01091//PF13939//PF16178 PTN/MK heparin-binding protein family, C-terminal domain//Toxin TisB, type I toxin-antitoxin system//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0008283//GO:0007165//GO:0040007//GO:0006820//GO:0022611//GO:0009432 cell proliferation//signal transduction//growth//anion transport//dormancy process//SOS response GO:0046983//GO:0008083//GO:0005253 protein dimerization activity//growth factor activity//anion channel activity GO:0005887 integral component of plasma membrane KOG2514 Uncharacterized conserved protein Cluster-8309.42740 BF_2 104.31 1.24 3795 642937773 XP_008198939.1 3931 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X1 [Tribolium castaneum]>gi|270000767|gb|EEZ97214.1| hypothetical protein TcasGA2_TC011007 [Tribolium castaneum] 665815760 XM_008558331.1 166 9.06265e-79 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 2218 6.5e-248 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF05309//PF00122 TraE protein//E1-E2 ATPase GO:0006812//GO:0000746//GO:0015917//GO:0015914 cation transport//conjugation//aminophospholipid transport//phospholipid transport GO:0000166//GO:0046872//GO:0000287//GO:0005524//GO:0015662//GO:0004012 nucleotide binding//metal ion binding//magnesium ion binding//ATP binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//phospholipid-translocating ATPase activity GO:0016021 integral component of membrane KOG0206 P-type ATPase Cluster-8309.42741 BF_2 360.96 2.40 6579 642937777 XP_008198941.1 5493 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IM isoform X3 [Tribolium castaneum] 665815760 XM_008558331.1 166 1.57673e-78 PREDICTED: Microplitis demolitor probable phospholipid-transporting ATPase ID (LOC103577611), transcript variant X4, mRNA K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 P98198 3294 0.0e+00 Phospholipid-transporting ATPase ID OS=Homo sapiens GN=ATP8B2 PE=1 SV=2 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.42742 BF_2 3714.25 53.29 3203 91091818 XP_966528.1 1772 7.0e-195 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum]>gi|270001103|gb|EEZ97550.1| hypothetical protein TcasGA2_TC011400 [Tribolium castaneum] -- -- -- -- -- K05201 GRIK1 glutamate receptor, ionotropic kainate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05201 P39087 1300 1.5e-141 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF00060//PF10613//PF06495//PF03509 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site//Fruit fly transformer protein//Gap junction alpha-8 protein (Cx50) GO:0007154//GO:0046660//GO:0006811//GO:0007165//GO:0006397//GO:0007268//GO:0006810 cell communication//female sex differentiation//ion transport//signal transduction//mRNA processing//synaptic transmission//transport GO:0005215//GO:0004970//GO:0005234 transporter activity//ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020//GO:0005922//GO:0005634 membrane//connexon complex//nucleus -- -- Cluster-8309.42743 BF_2 1039.83 5.26 8554 642923695 XP_008193847.1 6170 0.0e+00 PREDICTED: piezo-type mechanosensitive ion channel component 2 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- M9MSG8 1849 9.0e-205 Piezo-type mechanosensitive ion channel component OS=Drosophila melanogaster GN=Piezo PE=2 SV=1 PF03361//PF15723//PF00122 Herpes virus intermediate/early protein 2/3//Motility quorum-sensing regulator, toxin of MqsA//E1-E2 ATPase GO:0009372//GO:0017148//GO:0042710//GO:0006355 quorum sensing//negative regulation of translation//biofilm formation//regulation of transcription, DNA-templated GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG1893 Uncharacterized conserved protein Cluster-8309.42744 BF_2 107.11 0.78 6065 189240413 XP_969795.2 2244 2.4e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.26177e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.3e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00498//PF00250 FHA domain//Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0005515//GO:0003700 sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42745 BF_2 17.01 0.49 1738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42747 BF_2 25.67 0.97 1391 642928939 XP_008195625.1 1132 4.9e-121 PREDICTED: UTP--glucose-1-phosphate uridylyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00963 UGP2, galU, galF UTP--glucose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00963 Q07130 835 5.6e-88 UTP--glucose-1-phosphate uridylyltransferase OS=Bos taurus GN=UGP2 PE=1 SV=2 PF01704 UTP--glucose-1-phosphate uridylyltransferase GO:0008152 metabolic process GO:0070569 uridylyltransferase activity -- -- KOG2638 UDP-glucose pyrophosphorylase Cluster-8309.42748 BF_2 87.54 7.00 810 91087535 XP_970133.1 481 8.8e-46 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] -- -- -- -- -- K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 319 2.2e-28 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.42749 BF_2 440.48 4.69 4217 642913457 XP_008201020.1 4121 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2238 3.5e-250 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00784//PF00023//PF13606 MyTH4 domain//Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.42750 BF_2 61.84 0.72 3858 642911681 XP_008200699.1 3110 0.0e+00 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1160 3.2e-125 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF07647//PF01852//PF00620//PF03121 SAM domain (Sterile alpha motif)//START domain//RhoGAP domain//Herpesviridae UL52/UL70 DNA primase GO:0006351//GO:0007165//GO:0006269//GO:0006260 transcription, DNA-templated//signal transduction//DNA replication, synthesis of RNA primer//DNA replication GO:0005515//GO:0008289//GO:0003896 protein binding//lipid binding//DNA primase activity GO:0005657//GO:0005730 replication fork//nucleolus KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.42751 BF_2 40.00 0.55 3328 546682942 ERL92821.1 301 2.7e-24 hypothetical protein D910_10129 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42752 BF_2 534.88 7.14 3420 91081375 XP_972116.1 4329 0.0e+00 PREDICTED: chromatin-remodeling complex ATPase chain Iswi [Tribolium castaneum]>gi|270005181|gb|EFA01629.1| hypothetical protein TcasGA2_TC007199 [Tribolium castaneum] 815799995 XR_001100589.1 645 0 PREDICTED: Linepithema humile chromatin-remodeling complex ATPase chain Iswi (LOC105671246), transcript variant X2, misc_RNA K11654 SMARCA5, SNF2H, ISWI SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K11654 Q24368 3762 0.0e+00 Chromatin-remodeling complex ATPase chain Iswi OS=Drosophila melanogaster GN=Iswi PE=1 SV=1 PF09111//PF06422//PF05416//PF04851//PF09110//PF00176//PF13892//PF00270 SLIDE//CDR ABC transporter//Southampton virus-type processing peptidase//Type III restriction enzyme, res subunit//HAND//SNF2 family N-terminal domain//DNA-binding domain//DEAD/DEAH box helicase GO:0006338//GO:0006810//GO:0043044//GO:0006508 chromatin remodeling//transport//ATP-dependent chromatin remodeling//proteolysis GO:0005524//GO:0016787//GO:0016818//GO:0042626//GO:0031491//GO:0004386//GO:0003677//GO:0004197//GO:0003676 ATP binding//hydrolase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATPase activity, coupled to transmembrane movement of substances//nucleosome binding//helicase activity//DNA binding//cysteine-type endopeptidase activity//nucleic acid binding GO:0016585//GO:0016021//GO:0005634//GO:0000785 obsolete chromatin remodeling complex//integral component of membrane//nucleus//chromatin KOG0385 Chromatin remodeling complex WSTF-ISWI, small subunit Cluster-8309.42754 BF_2 18.59 0.60 1582 741829289 AJA91071.1 627 2.0e-62 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 538 1.7e-53 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42755 BF_2 31.75 0.55 2708 741829858 AJA91073.1 1179 3.4e-126 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 919 2.0e-97 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42757 BF_2 12.78 0.34 1857 322786223 EFZ12827.1 793 1.3e-81 hypothetical protein SINV_02089, partial [Solenopsis invicta] 505849574 XM_004618186.1 109 2.13301e-47 PREDICTED: Sorex araneus adaptor-related protein complex 3, sigma 1 subunit (AP3S1), mRNA K12399 AP3S AP-3 complex subunit sigma http://www.genome.jp/dbget-bin/www_bget?ko:K12399 Q8BSZ2 695 1.3e-71 AP-3 complex subunit sigma-2 OS=Mus musculus GN=Ap3s2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0936 Clathrin adaptor complex, small subunit Cluster-8309.42758 BF_2 922.22 13.81 3080 642929390 XP_008195816.1 919 5.5e-96 PREDICTED: cysteine dioxygenase type 1 [Tribolium castaneum]>gi|270010522|gb|EFA06970.1| hypothetical protein TcasGA2_TC009929 [Tribolium castaneum] -- -- -- -- -- K00456 CDO1 cysteine dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00456 Q6NWZ9 594 1.1e-59 Cysteine dioxygenase type 1 OS=Danio rerio GN=cdo1 PE=2 SV=1 PF07847//PF05995 Protein of unknown function (DUF1637)//Cysteine dioxygenase type I GO:0019530//GO:0006534//GO:0055114//GO:0046439 taurine metabolic process//cysteine metabolic process//oxidation-reduction process//L-cysteine metabolic process GO:0005506//GO:0016702//GO:0017172 iron ion binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//cysteine dioxygenase activity -- -- KOG4064 Cysteine dioxygenase CDO1 Cluster-8309.42759 BF_2 126.02 2.54 2361 642932773 XP_008196977.1 3190 0.0e+00 PREDICTED: dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 isoform X1 [Tribolium castaneum] 759067243 XM_011344784.1 294 3.92755e-150 PREDICTED: Cerapachys biroi dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11-like (LOC105282642), transcript variant X2, mRNA K13298 PDE11 dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13298 Q9VJ79 2157 4.8e-241 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11 OS=Drosophila melanogaster GN=Pde11 PE=1 SV=4 PF00233//PF01590//PF13492//PF13185//PF07533 3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain//GAF domain//BRK domain GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114//GO:0016817//GO:0005515 3',5'-cyclic-nucleotide phosphodiesterase activity//hydrolase activity, acting on acid anhydrides//protein binding -- -- -- -- Cluster-8309.42760 BF_2 132.90 3.34 1950 91084515 XP_967225.1 680 1.8e-68 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.42762 BF_2 254.97 2.03 5550 642936966 XP_008198632.1 3226 0.0e+00 PREDICTED: rab GTPase-activating protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RAN1 1670 3.3e-184 Rab GTPase-activating protein 1 OS=Pongo abelii GN=RABGAP1 PE=2 SV=1 PF13465//PF05443//PF00640//PF02892//PF13912//PF16622//PF00096//PF14719//PF07776 Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//Phosphotyrosine interaction domain (PTB/PID)//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Phosphotyrosine interaction domain (PTB/PID)//Zinc-finger associated domain (zf-AD) GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046872//GO:0008270//GO:0003677 protein binding//metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.42763 BF_2 1020.00 41.35 1319 642937391 XP_008198818.1 397 7.9e-36 PREDICTED: carboxypeptidase N subunit 2-like [Tribolium castaneum]>gi|270001112|gb|EEZ97559.1| hypothetical protein TcasGA2_TC011413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80X72 276 3.5e-23 Leucine-rich repeat-containing protein 15 OS=Mus musculus GN=Lrrc15 PE=2 SV=1 PF13855//PF00560//PF03328 Leucine rich repeat//Leucine Rich Repeat//HpcH/HpaI aldolase/citrate lyase family -- -- GO:0005515//GO:0003824 protein binding//catalytic activity -- -- -- -- Cluster-8309.42764 BF_2 1370.00 9.66 6218 642932323 XP_008197064.1 2163 6.2e-240 PREDICTED: mucin-17-like [Tribolium castaneum]>gi|270011608|gb|EFA08056.1| hypothetical protein TcasGA2_TC005652 [Tribolium castaneum] 462278420 APGK01058650.1 63 2.69586e-21 Dendroctonus ponderosae Seq01058660, whole genome shotgun sequence -- -- -- -- Q13231 222 3.0e-16 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF01607 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553//GO:0043169 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding GO:0005576 extracellular region -- -- Cluster-8309.42765 BF_2 168.05 0.71 10166 642926973 XP_008195085.1 2249 1.1e-249 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 1.1e-76 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF08031//PF10186//PF05791//PF03650//PF06206//PF00621//PF02948 Berberine and berberine like//Vacuolar sorting 38 and autophagy-related subunit 14//Bacillus haemolytic enterotoxin (HBL)//Uncharacterised protein family (UPF0041)//CpeT/CpcT family (DUF1001)//RhoGEF domain//Amelogenin GO:0010508//GO:0017009//GO:0055114//GO:0043087//GO:0006850//GO:0009405//GO:0035023//GO:0007275 positive regulation of autophagy//protein-phycocyanobilin linkage//oxidation-reduction process//regulation of GTPase activity//mitochondrial pyruvate transport//pathogenesis//regulation of Rho protein signal transduction//multicellular organismal development GO:0005089//GO:0050660//GO:0016491 Rho guanyl-nucleotide exchange factor activity//flavin adenine dinucleotide binding//oxidoreductase activity GO:0005578//GO:0016020//GO:0005743 proteinaceous extracellular matrix//membrane//mitochondrial inner membrane -- -- Cluster-8309.42766 BF_2 115.51 0.57 8734 642926973 XP_008195085.1 2758 8.8e-309 PREDICTED: rho guanine nucleotide exchange factor 18 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16529 AKAP13 A-kinase anchor protein 13 http://www.genome.jp/dbget-bin/www_bget?ko:K16529 Q8N1W1 745 9.6e-77 Rho guanine nucleotide exchange factor 28 OS=Homo sapiens GN=ARHGEF28 PE=1 SV=3 PF05529//PF00130//PF03650//PF07649//PF05791//PF00628//PF00621 B-cell receptor-associated protein 31-like//Phorbol esters/diacylglycerol binding domain (C1 domain)//Uncharacterised protein family (UPF0041)//C1-like domain//Bacillus haemolytic enterotoxin (HBL)//PHD-finger//RhoGEF domain GO:0035556//GO:0055114//GO:0043087//GO:0006850//GO:0006886//GO:0009405//GO:0035023 intracellular signal transduction//oxidation-reduction process//regulation of GTPase activity//mitochondrial pyruvate transport//intracellular protein transport//pathogenesis//regulation of Rho protein signal transduction GO:0005089//GO:0047134//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein-disulfide reductase activity//protein binding GO:0016020//GO:0005783//GO:0016021//GO:0005743 membrane//endoplasmic reticulum//integral component of membrane//mitochondrial inner membrane -- -- Cluster-8309.42767 BF_2 77.04 0.46 7250 642931401 XP_008196564.1 7208 0.0e+00 PREDICTED: brefeldin A-inhibited guanine nucleotide-exchange protein 3 [Tribolium castaneum] 170051315 XM_001861674.1 59 5.26181e-19 Culex quinquefasciatus BIG3, mRNA K17572 ARFGEF3, KEPI brefeldin A-inhibited guanine nucleotide-exchange protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17572 Q3UGY8 1263 6.8e-137 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 OS=Mus musculus GN=Arfgef3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0929 Guanine nucleotide exchange factor Cluster-8309.42769 BF_2 50.31 0.82 2868 91082351 XP_967256.1 712 5.1e-72 PREDICTED: probable uridine nucleosidase 1 [Tribolium castaneum]>gi|270007493|gb|EFA03941.1| hypothetical protein TcasGA2_TC014082 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q10314 203 2.2e-14 Uncharacterized protein C17G8.02 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC17G8.02 PE=3 SV=1 PF01105//PF06156//PF02212//PF01496 emp24/gp25L/p24 family/GOLD//Protein of unknown function (DUF972)//Dynamin GTPase effector domain//V-type ATPase 116kDa subunit family GO:0006260//GO:0015992//GO:0006810//GO:0015991 DNA replication//proton transport//transport//ATP hydrolysis coupled proton transport GO:0005525//GO:0015078//GO:0003924 GTP binding//hydrogen ion transmembrane transporter activity//GTPase activity GO:0033179//GO:0016021 proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG2938 Predicted inosine-uridine preferring nucleoside hydrolase Cluster-8309.42771 BF_2 11.01 2.59 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42772 BF_2 26.00 0.38 3144 270007530 EFA03978.1 1703 6.9e-187 hypothetical protein TcasGA2_TC014127 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N695 750 9.1e-78 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.42775 BF_2 145.49 1.47 4418 270001801 EEZ98248.1 1216 2.8e-130 hypothetical protein TcasGA2_TC000687 [Tribolium castaneum] 817087970 XM_012411364.1 53 6.92165e-16 PREDICTED: Athalia rosae Y+L amino acid transporter 2 (LOC105692280), transcript variant X4, mRNA K13872 SLC7A6 solute carrier family 7 (L-type amino acid transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K13872 Q8BGK6 703 3.6e-72 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF01990//PF13520//PF00324//PF01424 ATP synthase (F/14-kDa) subunit//Amino acid permease//Amino acid permease//R3H domain GO:0003333//GO:0006865//GO:0055085//GO:0034220//GO:0006810 amino acid transmembrane transport//amino acid transport//transmembrane transport//ion transmembrane transport//transport GO:0003676//GO:0015171 nucleic acid binding//amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.42776 BF_2 72.00 7.48 690 642915065 XP_008190395.1 375 1.5e-33 PREDICTED: protein groucho isoform X1 [Tribolium castaneum]>gi|270002870|gb|EEZ99317.1| groucho-like protein [Tribolium castaneum] 642915072 XM_008192177.1 141 1.24963e-65 PREDICTED: Tribolium castaneum protein groucho (LOC656496), transcript variant X5, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 348 8.2e-32 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF04136//PF03920//PF02183 Sec34-like family//Groucho/TLE N-terminal Q-rich domain//Homeobox associated leucine zipper GO:0006886//GO:0006355 intracellular protein transport//regulation of transcription, DNA-templated GO:0005515//GO:0043565//GO:0003700 protein binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0016020//GO:0005801 nucleus//transcription factor complex//membrane//cis-Golgi network -- -- Cluster-8309.42777 BF_2 366.09 7.07 2452 642915067 XP_008190396.1 2531 5.2e-283 PREDICTED: protein groucho isoform X2 [Tribolium castaneum] 602715430 XM_007467859.1 376 0 PREDICTED: Lipotes vexillifer transducin-like enhancer of split 3 (TLE3), transcript variant X12, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 2053 5.7e-229 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF03920//PF00400 Groucho/TLE N-terminal Q-rich domain//WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.42781 BF_2 1118.88 29.68 1864 91082269 XP_973494.1 933 7.9e-98 PREDICTED: eukaryotic translation initiation factor 4E-1A [Tribolium castaneum]>gi|270008177|gb|EFA04625.1| eukaryotic initiation factor 4E [Tribolium castaneum] -- -- -- -- -- K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 Q9DFS6 636 8.9e-65 Eukaryotic translation initiation factor 4E-1A OS=Danio rerio GN=eif4e1a PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.42782 BF_2 405.06 10.20 1949 642936684 XP_001807897.2 847 7.7e-88 PREDICTED: uncharacterized protein LOC100142617 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18120 217 3.6e-16 TWiK family of potassium channels protein 18 OS=Caenorhabditis elegans GN=twk-18 PE=1 SV=2 PF06423//PF01536 GWT1//Adenosylmethionine decarboxylase GO:0006525//GO:0008295//GO:0006560//GO:0006506//GO:0006597 arginine metabolic process//spermidine biosynthetic process//proline metabolic process//GPI anchor biosynthetic process//spermine biosynthetic process GO:0004014//GO:0016746 adenosylmethionine decarboxylase activity//transferase activity, transferring acyl groups GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.42783 BF_2 516.09 5.64 4116 270011364 EFA07812.1 3337 0.0e+00 hypothetical protein TcasGA2_TC005373 [Tribolium castaneum] 749776083 XM_011144769.1 306 1.46985e-156 PREDICTED: Harpegnathos saltator probable ATP-dependent RNA helicase DDX46 (LOC105185358), transcript variant X2, mRNA K12811 DDX46, PRP5 ATP-dependent RNA helicase DDX46/PRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K12811 Q7L014 2441 9.8e-274 Probable ATP-dependent RNA helicase DDX46 OS=Homo sapiens GN=DDX46 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676 ATP binding//nucleic acid binding -- -- KOG0334 RNA helicase Cluster-8309.42787 BF_2 29.36 0.55 2505 546680789 ERL90995.1 1582 5.9e-173 hypothetical protein D910_08337 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P83501 277 5.1e-23 Protein msta, isoform B OS=Drosophila melanogaster GN=msta PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42789 BF_2 6.24 0.37 1001 270002414 EEZ98861.1 187 1.3e-11 hypothetical protein TcasGA2_TC004472 [Tribolium castaneum] -- -- -- -- -- K06546 CD164, MGC24 CD164 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42790 BF_2 766.00 10.66 3292 282720995 NP_001164248.1 1593 4.1e-174 cytochrome P450 9Z4 [Tribolium castaneum]>gi|270012794|gb|EFA09242.1| cytochrome P450 9Z4 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1098 4.2e-118 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF05374 Cytochrome P450//Mu-Conotoxin GO:0009405//GO:0006810//GO:0055114 pathogenesis//transport//oxidation-reduction process GO:0016705//GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0019871 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity//iron ion binding//metal ion binding//heme binding//sodium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.42791 BF_2 48.18 1.07 2173 642931814 XP_008196744.1 1081 6.3e-115 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q964T2 779 2.7e-81 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42792 BF_2 23.24 0.72 1636 546674178 ERL85623.1 816 2.5e-84 hypothetical protein D910_03042 [Dendroctonus ponderosae] 689931529 LM413879.1 39 1.53328e-08 Enterobius vermicularis genome assembly E_vermicularis_Canary_Islands ,scaffold EVEC_scaffold0000328 K03019 RPC11, POLR3K DNA-directed RNA polymerase III subunit RPC11 http://www.genome.jp/dbget-bin/www_bget?ko:K03019 Q0VC80 388 4.5e-36 YrdC domain-containing protein, mitochondrial OS=Bos taurus GN=YRDC PE=2 SV=1 PF01300 Telomere recombination -- -- GO:0003725 double-stranded RNA binding -- -- KOG2906 RNA polymerase III subunit C11 Cluster-8309.42794 BF_2 6365.00 23.96 11402 642916133 XP_008190900.1 13009 0.0e+00 PREDICTED: laminin subunit alpha [Tribolium castaneum] -- -- -- -- -- K06240 LAMA3_5 laminin, alpha 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K06240 Q00174 7920 0.0e+00 Laminin subunit alpha OS=Drosophila melanogaster GN=LanA PE=1 SV=2 PF06667//PF06008//PF04136//PF04384//PF06009 Phage shock protein B//Laminin Domain I//Sec34-like family//Iron-sulphur cluster assembly//Laminin Domain II GO:0006355//GO:0007155//GO:0030155//GO:0045995//GO:0009271//GO:0016226//GO:0007165//GO:0030334//GO:0006886 regulation of transcription, DNA-templated//cell adhesion//regulation of cell adhesion//regulation of embryonic development//phage shock//iron-sulfur cluster assembly//signal transduction//regulation of cell migration//intracellular protein transport GO:0005102 receptor binding GO:0005801//GO:0016020 cis-Golgi network//membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.42797 BF_2 96.63 0.54 7837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42798 BF_2 147.49 13.33 750 91086893 XP_970527.1 454 1.1e-42 PREDICTED: protein CDV3 homolog isoform X2 [Tribolium castaneum]>gi|270009679|gb|EFA06127.1| hypothetical protein TcasGA2_TC008970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42799 BF_2 766.65 9.34 3722 546684210 ERL93915.1 1800 4.6e-198 hypothetical protein D910_11201 [Dendroctonus ponderosae] 725576925 XM_010342216.1 119 1.19095e-52 PREDICTED: Saimiri boliviensis boliviensis LIM and senescent cell antigen-like domains 2 (LIMS2), transcript variant X11, mRNA -- -- -- -- Q7Z4I7 1311 9.5e-143 LIM and senescent cell antigen-like-containing domain protein 2 OS=Homo sapiens GN=LIMS2 PE=1 SV=1 PF00614//PF00412 Phospholipase D Active site motif//LIM domain -- -- GO:0003824//GO:0008270 catalytic activity//zinc ion binding -- -- KOG2272 Focal adhesion protein PINCH-1, contains LIM domains Cluster-8309.4280 BF_2 1.00 1.96 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42800 BF_2 192.00 1.34 6261 642920713 XP_008192532.1 261 2.2e-19 PREDICTED: uncharacterized protein LOC103312793 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42802 BF_2 20.56 1.27 964 642920713 XP_008192532.1 523 1.4e-50 PREDICTED: uncharacterized protein LOC103312793 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42806 BF_2 432.85 3.51 5445 642940052 XP_008200969.1 2913 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF07728//PF01695//PF06068//PF05496//PF00439//PF00004//PF07724//PF00005//PF04851//PF00910 AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Bromodomain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ABC transporter//Type III restriction enzyme, res subunit//RNA helicase GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0003678//GO:0005524//GO:0003677//GO:0016787//GO:0005515 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//DNA helicase activity//ATP binding//DNA binding//hydrolase activity//protein binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.42807 BF_2 2238.30 6.05 15755 189237595 XP_966729.2 2234 9.2e-248 PREDICTED: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [Tribolium castaneum] 642910996 XM_968304.3 331 7.16614e-170 PREDICTED: Tribolium castaneum single-stranded DNA-binding protein 3 (LOC662190), transcript variant X3, mRNA K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 P49071 1432 3.8e-156 MAP kinase-activated protein kinase 2 OS=Drosophila melanogaster GN=MAPk-Ak2 PE=2 SV=1 PF06293//PF08001//PF06016//PF00155//PF01212//PF01053//PF09029//PF07714//PF00069 Lipopolysaccharide kinase (Kdo/WaaP) family//CMV US//Reovirus core-spike protein lambda-2 (L2)//Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//5-aminolevulinate synthase presequence//Protein tyrosine kinase//Protein kinase domain GO:0006544//GO:0006783//GO:0006520//GO:0006370//GO:0030683//GO:0009451//GO:0006468//GO:0042967//GO:0006563//GO:0009058//GO:0006778//GO:0006566 glycine metabolic process//heme biosynthetic process//cellular amino acid metabolic process//7-methylguanosine mRNA capping//evasion or tolerance by virus of host immune response//RNA modification//protein phosphorylation//acyl-carrier-protein biosynthetic process//L-serine metabolic process//biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process GO:0030170//GO:0003870//GO:0004484//GO:0004482//GO:0004672//GO:0016773//GO:0005524//GO:0016829 pyridoxal phosphate binding//5-aminolevulinate synthase activity//mRNA guanylyltransferase activity//mRNA (guanine-N7-)-methyltransferase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding//lyase activity GO:0005759//GO:0016020//GO:0019028//GO:0044386 mitochondrial matrix//membrane//viral capsid//integral to host endoplasmic reticulum membrane KOG0604 MAP kinase-activated protein kinase 2 Cluster-8309.42808 BF_2 12.35 0.60 1141 478256608 ENN76790.1 343 1.2e-29 hypothetical protein YQE_06631, partial [Dendroctonus ponderosae] 462333164 APGK01039067.1 96 2.18469e-40 Dendroctonus ponderosae Seq01039077, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42809 BF_2 66.23 0.89 3409 -- -- -- -- -- 642935330 XM_008199749.1 107 5.10645e-46 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC656292), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF06112//PF00424 Gammaherpesvirus capsid protein//REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0019028//GO:0042025//GO:0005667 viral capsid//host cell nucleus//transcription factor complex -- -- Cluster-8309.42810 BF_2 205.06 1.71 5306 642934118 XP_008199283.1 1895 6.3e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1299 3.3e-141 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.42811 BF_2 18.81 1.67 757 282158091 NP_001164089.1 411 1.1e-37 farnesyl pyrophosphate synthase [Tribolium castaneum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 Q92250 320 1.6e-28 Farnesyl pyrophosphate synthase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=fpp PE=3 SV=2 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.42812 BF_2 1455.00 33.19 2121 403234001 AFR31785.1 1015 2.8e-107 putative farnesyl diphosphate synthase [Tetropium fuscum] -- -- -- -- -- K00787 FDPS farnesyl diphosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00787 Q8WMY2 572 2.7e-57 Farnesyl pyrophosphate synthase OS=Bos taurus GN=FDPS PE=1 SV=1 PF00348 Polyprenyl synthetase GO:0008299 isoprenoid biosynthetic process -- -- -- -- KOG0711 Polyprenyl synthetase Cluster-8309.42814 BF_2 1192.22 33.59 1772 332374874 AEE62578.1 590 4.4e-58 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1HRV8 391 2.2e-36 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01036//PF01151 Bacteriorhodopsin-like protein//GNS1/SUR4 family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.42815 BF_2 102.98 2.48 2027 332374874 AEE62578.1 403 2.4e-36 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10249 ELOVL4 elongation of very long chain fatty acids protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10249 Q3S8M4 238 1.4e-18 Elongation of very long chain fatty acids protein 4 OS=Macaca mulatta GN=ELOVL4 PE=3 SV=1 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42816 BF_2 2522.03 57.85 2111 332375919 AEE63100.1 2238 4.2e-249 unknown [Dendroctonus ponderosae]>gi|478263200|gb|ENN81590.1| hypothetical protein YQE_02000, partial [Dendroctonus ponderosae]>gi|546674112|gb|ERL85582.1| hypothetical protein D910_03001 [Dendroctonus ponderosae] 826407846 XM_012667203.1 410 0 PREDICTED: Monomorium pharaonis AP-2 complex subunit mu (LOC105828717), transcript variant X2, mRNA K11826 AP2M1 AP-2 complex subunit mu-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11826 Q5ZMP6 1996 2.0e-222 AP-2 complex subunit mu OS=Gallus gallus GN=AP2M1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0938 Adaptor complexes medium subunit family Cluster-8309.42819 BF_2 48.35 6.70 589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42821 BF_2 1182.36 9.95 5257 91090366 XP_968305.1 2290 9.8e-255 PREDICTED: T-cell immunomodulatory protein [Tribolium castaneum]>gi|270013408|gb|EFA09856.1| hypothetical protein TcasGA2_TC012004 [Tribolium castaneum] 765338960 XM_011495191.1 147 4.59175e-68 Aedes aegypti AAEL017098-RA partial mRNA K17257 ITFG1 integrin alpha FG-GAP repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17257 P18459 993 1.0e-105 Tyrosine 3-monooxygenase OS=Drosophila melanogaster GN=ple PE=2 SV=2 PF00351 Biopterin-dependent aromatic amino acid hydroxylase GO:0055114 oxidation-reduction process GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.42823 BF_2 191.26 1.13 7383 642922200 XP_008193059.1 2412 9.9e-269 PREDICTED: patronin isoform X6 [Tribolium castaneum] 645007691 XM_008218148.1 77 5.28354e-29 PREDICTED: Nasonia vitripennis patronin (LOC100118026), mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 1217 1.5e-131 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF17095 Spectrin-binding region of Ca2+-Calmodulin GO:0031175 neuron projection development GO:0005516//GO:0030507 calmodulin binding//spectrin binding GO:0008091 spectrin KOG3654 Uncharacterized CH domain protein Cluster-8309.42824 BF_2 1951.60 11.58 7336 642922200 XP_008193059.1 2412 9.8e-269 PREDICTED: patronin isoform X6 [Tribolium castaneum] 645007691 XM_008218148.1 77 5.24974e-29 PREDICTED: Nasonia vitripennis patronin (LOC100118026), mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 1217 1.5e-131 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF17095 Spectrin-binding region of Ca2+-Calmodulin GO:0031175 neuron projection development GO:0005516//GO:0030507 calmodulin binding//spectrin binding GO:0008091 spectrin KOG3654 Uncharacterized CH domain protein Cluster-8309.42827 BF_2 6.00 0.38 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42828 BF_2 141.26 0.93 6671 642919657 XP_008192010.1 2454 1.2e-273 PREDICTED: kinesin light chain isoform X2 [Tribolium castaneum]>gi|270005876|gb|EFA02324.1| hypothetical protein TcasGA2_TC007992 [Tribolium castaneum] 817205694 XM_012423343.1 217 7.12982e-107 PREDICTED: Orussus abietinus kinesin light chain (LOC105698786), transcript variant X7, mRNA K10407 KLC kinesin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10407 P46824 1676 8.1e-185 Kinesin light chain OS=Drosophila melanogaster GN=Klc PE=1 SV=1 PF13176//PF11365//PF13414//PF13374//PF00515//PF07989//PF03836//PF06005//PF09730//PF13174//PF06156//PF13181//PF07721//PF01239 Tetratricopeptide repeat//Protein of unknown function (DUF3166)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Centrosomin N-terminal motif 1//RasGAP C-terminus//Protein of unknown function (DUF904)//Microtubule-associated protein Bicaudal-D//Tetratricopeptide repeat//Protein of unknown function (DUF972)//Tetratricopeptide repeat//Tetratricopeptide repeat//Protein prenyltransferase alpha subunit repeat GO:0007264//GO:0000917//GO:0043093//GO:0018342//GO:0007017//GO:0006260//GO:0006810//GO:0010506 small GTPase mediated signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis//protein prenylation//microtubule-based process//DNA replication//transport//regulation of autophagy GO:0003777//GO:0005515//GO:0042802//GO:0008318//GO:0005096 microtubule motor activity//protein binding//identical protein binding//protein prenyltransferase activity//GTPase activator activity GO:0005874//GO:0005615//GO:0005737//GO:0005794//GO:0005871//GO:0005815 microtubule//extracellular space//cytoplasm//Golgi apparatus//kinesin complex//microtubule organizing center KOG1840 Kinesin light chain Cluster-8309.42829 BF_2 183.19 1.67 4886 801375633 XP_012063602.1 310 3.6e-25 PREDICTED: zinc finger protein 2-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- Q9CXE0 278 7.6e-23 PR domain zinc finger protein 5 OS=Mus musculus GN=Prdm5 PE=2 SV=2 PF00130//PF00096//PF05715//PF08996//PF06061//PF07776//PF13465//PF01844//PF02892//PF13912//PF01363 Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Piccolo Zn-finger//DNA Polymerase alpha zinc finger//Baculoviridae ME53//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//HNH endonuclease//BED zinc finger//C2H2-type zinc finger//FYVE zinc finger GO:0035556//GO:0006260 intracellular signal transduction//DNA replication GO:0046872//GO:0001882//GO:0003676//GO:0008270//GO:0003887//GO:0003677//GO:0004519 metal ion binding//nucleoside binding//nucleic acid binding//zinc ion binding//DNA-directed DNA polymerase activity//DNA binding//endonuclease activity GO:0045202//GO:0042575//GO:0005634 synapse//DNA polymerase complex//nucleus -- -- Cluster-8309.42830 BF_2 983.74 11.94 3735 270001368 EEZ97815.1 2868 0.0e+00 hypothetical protein TcasGA2_TC000182 [Tribolium castaneum] 170046948 XM_001850953.1 142 1.95792e-65 Culex quinquefasciatus tyrosine phosphatase n9, mRNA K18038 PTPN9, MEG2 tyrosine-protein phosphatase non-receptor type 9 http://www.genome.jp/dbget-bin/www_bget?ko:K18038 Q641Z2 1365 5.2e-149 Tyrosine-protein phosphatase non-receptor type 9 OS=Rattus norvegicus GN=Ptpn9 PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.42831 BF_2 484.87 4.96 4373 91078200 XP_968428.1 1153 5.7e-123 PREDICTED: m7GpppN-mRNA hydrolase [Tribolium castaneum]>gi|270001356|gb|EEZ97803.1| hypothetical protein TcasGA2_TC000167 [Tribolium castaneum] -- -- -- -- -- K12613 DCP2 mRNA-decapping enzyme subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12613 Q5REQ8 712 3.2e-73 m7GpppN-mRNA hydrolase OS=Pongo abelii GN=DCP2 PE=2 SV=1 PF05026//PF00293//PF08273//PF15957 Dcp2, box A domain//NUDIX domain//Zinc-binding domain of primase-helicase//Commissureless GO:0006269//GO:0006351//GO:0007411 DNA replication, synthesis of RNA primer//transcription, DNA-templated//axon guidance GO:0008270//GO:0030145//GO:0004386//GO:0003723//GO:0016787//GO:0003896 zinc ion binding//manganese ion binding//helicase activity//RNA binding//hydrolase activity//DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2 Cluster-8309.42832 BF_2 185.41 2.01 4143 642935662 XP_008198105.1 1005 7.8e-106 PREDICTED: cytochrome b reductase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 3.1e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF00033//PF03188//PF01292 Cytochrome b/b6/petB//Eukaryotic cytochrome b561//Prokaryotic cytochrome b561 GO:0022904//GO:0006118 respiratory electron transport chain//obsolete electron transport GO:0009055 electron carrier activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1619 Cytochrome b Cluster-8309.42833 BF_2 578.57 12.48 2227 642934951 XP_008195932.1 2525 2.3e-282 PREDICTED: protein MTO1 homolog, mitochondrial [Tribolium castaneum] -- -- -- -- -- K03495 gidA, mnmG, MTO1 tRNA uridine 5-carboxymethylaminomethyl modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K03495 Q4R4P6 1807 1.7e-200 Protein MTO1 homolog, mitochondrial OS=Macaca fascicularis GN=MTO1 PE=2 SV=1 PF00070//PF12831//PF01134//PF07992//PF05834 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein GO:0055114//GO:0008033//GO:0016117 oxidation-reduction process//tRNA processing//carotenoid biosynthetic process GO:0016491//GO:0016705//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding -- -- KOG2311 NAD/FAD-utilizing protein possibly involved in translation Cluster-8309.42835 BF_2 6.29 0.37 1005 270015890 EFA12338.1 843 1.2e-87 hypothetical protein TcasGA2_TC016023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12297 430 3.7e-41 Protein suppressor of white apricot OS=Drosophila melanogaster GN=su(w[a]) PE=1 SV=3 PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- KOG1847 mRNA splicing factor Cluster-8309.42836 BF_2 28.29 0.51 2608 642914654 XP_008190301.1 1586 2.1e-173 PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|642914656|ref|XP_008190302.1| PREDICTED: protein CREBRF homolog [Tribolium castaneum]>gi|270001446|gb|EEZ97893.1| hypothetical protein TcasGA2_TC000275 [Tribolium castaneum] 759055308 XM_011338582.1 42 5.29638e-10 PREDICTED: Cerapachys biroi protein CREBRF homolog (LOC105279044), transcript variant X2, mRNA -- -- -- -- Q9VC61 625 2.3e-63 Protein CREBRF homolog OS=Drosophila melanogaster GN=CG13624 PE=2 SV=2 PF00170//PF07716 bZIP transcription factor//Basic region leucine zipper GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.42837 BF_2 678.51 9.80 3184 91087297 XP_975561.1 2707 2.6e-303 PREDICTED: protein fem-1 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K10349 FEM1B Fem-1 homolog b http://www.genome.jp/dbget-bin/www_bget?ko:K10349 Q5ZM55 1739 1.9e-192 Protein fem-1 homolog B OS=Gallus gallus GN=FEM1B PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.42838 BF_2 125.89 2.46 2426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42839 BF_2 41.46 1.10 1858 91076494 XP_972946.1 286 8.3e-23 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 183 3.0e-12 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- GO:0055114 oxidation-reduction process GO:0016491//GO:0010181 oxidoreductase activity//FMN binding -- -- -- -- Cluster-8309.42840 BF_2 100.38 1.47 3145 91076494 XP_972946.1 151 6.3e-07 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05208 ALG3 protein -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum -- -- Cluster-8309.42841 BF_2 37.00 2.23 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42843 BF_2 1.00 38.47 203 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42844 BF_2 433.91 6.32 3157 91087297 XP_975561.1 2727 1.3e-305 PREDICTED: protein fem-1 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K10349 FEM1B Fem-1 homolog b http://www.genome.jp/dbget-bin/www_bget?ko:K10349 Q5ZM55 1759 9.1e-195 Protein fem-1 homolog B OS=Gallus gallus GN=FEM1B PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.42846 BF_2 29.00 1.36 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42847 BF_2 209.62 2.16 4345 91076494 XP_972946.1 151 8.7e-07 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42850 BF_2 5.50 1.36 456 645030788 XP_008214012.1 468 1.6e-44 PREDICTED: 40S ribosomal protein S18 [Nasonia vitripennis] 264667372 GU120422.1 126 1.75715e-57 Chrysomela tremulae ribosomal protein S18 (RpS18) mRNA, complete cds K02964 RP-S18e, RPS18 small subunit ribosomal protein S18e http://www.genome.jp/dbget-bin/www_bget?ko:K02964 Q962R1 427 3.7e-41 40S ribosomal protein S18 OS=Spodoptera frugiperda GN=RpS18 PE=2 SV=1 PF00416 Ribosomal protein S13/S18 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3311 Ribosomal protein S18 Cluster-8309.42853 BF_2 109.54 0.69 6946 102939 1496 1.5e-162 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 1171 3.0e-126 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF04137//PF03310//PF13683//PF00665//PF02966 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//Caulimovirus DNA-binding protein//Integrase core domain//Integrase core domain//Mitosis protein DIM1 GO:0015074//GO:0000398//GO:0055114 DNA integration//mRNA splicing, via spliceosome//oxidation-reduction process GO:0003756//GO:0016671//GO:0003677 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//DNA binding GO:0005783//GO:0005681 endoplasmic reticulum//spliceosomal complex -- -- Cluster-8309.42857 BF_2 4.00 0.46 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42859 BF_2 837.41 3.46 10398 546684972 ERL94546.1 4054 0.0e+00 hypothetical protein D910_11823 [Dendroctonus ponderosae] 768442001 XM_011564452.1 506 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q9Z1N3 1894 6.6e-210 Unconventional myosin-IXa OS=Rattus norvegicus GN=Myo9a PE=1 SV=1 PF00620//PF00788//PF09280//PF02954//PF15177//PF00612//PF12678//PF07649//PF00063//PF00628//PF00437//PF00130 RhoGAP domain//Ras association (RalGDS/AF-6) domain//XPC-binding domain//Bacterial regulatory protein, Fis family//Interleukin-28A//IQ calmodulin-binding motif//RING-H2 zinc finger//C1-like domain//Myosin head (motor domain)//PHD-finger//Type II/IV secretion system protein//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007259//GO:0051607//GO:0050778//GO:0043161//GO:0006289//GO:0007165//GO:0006281//GO:0006810//GO:0055114//GO:0035556 JAK-STAT cascade//defense response to virus//positive regulation of immune response//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair//signal transduction//DNA repair//transport//oxidation-reduction process//intracellular signal transduction GO:0005515//GO:0003774//GO:0003684//GO:0005524//GO:0005125//GO:0043565//GO:0008270//GO:0047134 protein binding//motor activity//damaged DNA binding//ATP binding//cytokine activity//sequence-specific DNA binding//zinc ion binding//protein-disulfide reductase activity GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.42864 BF_2 112.39 1.02 4890 642939097 XP_008200220.1 2017 4.1e-223 PREDICTED: uncharacterized protein LOC658083 isoform X1 [Tribolium castaneum]>gi|642939099|ref|XP_008200221.1| PREDICTED: uncharacterized protein LOC658083 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR5 1230 3.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0019882//GO:0006955 antigen processing and presentation//immune response -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.42865 BF_2 67.88 2.95 1249 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42868 BF_2 721.37 12.57 2688 642919711 XP_008192032.1 1828 1.9e-201 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X1 [Tribolium castaneum]>gi|270005898|gb|EFA02346.1| hypothetical protein TcasGA2_TC008016 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.4e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.42870 BF_2 238.72 3.67 3010 478258252 ENN78381.1 1023 4.7e-108 hypothetical protein YQE_05182, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 212 2.1e-15 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.42871 BF_2 48.57 0.53 4139 91078224 XP_969612.1 1927 9.6e-213 PREDICTED: cell division cycle protein 20 homolog [Tribolium castaneum]>gi|270002363|gb|EEZ98810.1| hypothetical protein TcasGA2_TC001383 [Tribolium castaneum] -- -- -- -- -- K03363 CDC20 cell division cycle 20, cofactor of APC complex http://www.genome.jp/dbget-bin/www_bget?ko:K03363 Q62623 1377 2.4e-150 Cell division cycle protein 20 homolog OS=Rattus norvegicus GN=Cdc20 PE=1 SV=2 PF00400//PF00498 WD domain, G-beta repeat//FHA domain -- -- GO:0005515 protein binding -- -- KOG0305 Anaphase promoting complex, Cdc20, Cdh1, and Ama1 subunits Cluster-8309.42872 BF_2 841.39 21.42 1930 546678419 ERL89042.1 305 5.4e-25 hypothetical protein D910_06420 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1ZB86 192 2.8e-13 Kelch domain-containing protein 10 homolog OS=Drosophila melanogaster GN=slim PE=1 SV=1 PF07646//PF01344 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.42873 BF_2 78.96 0.64 5483 642920861 XP_008192589.1 3650 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 630 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3150 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF16656//PF02480//PF07353//PF00041//PF07354//PF13895 Tissue factor//Purple acid Phosphatase, N-terminal domain//Alphaherpesvirus glycoprotein E//Uroplakin II//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain GO:0019497//GO:0007339//GO:0006771//GO:0061024 hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//riboflavin metabolic process//membrane organization GO:0005515//GO:0003993//GO:0046872 protein binding//acid phosphatase activity//metal ion binding GO:0030176//GO:0016020//GO:0005576 integral component of endoplasmic reticulum membrane//membrane//extracellular region -- -- Cluster-8309.42875 BF_2 96.93 0.64 6668 821117180 XP_012382122.1 458 3.4e-42 PREDICTED: zinc finger protein 883-like [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8C827 422 2.1e-39 Zinc finger protein 62 OS=Mus musculus GN=Zfp62 PE=2 SV=1 PF13912//PF07776//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.42876 BF_2 2397.44 29.00 3745 642938770 XP_008199881.1 1708 2.1e-187 PREDICTED: protein transport protein Sec16B-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15027 945 2.6e-100 Protein transport protein Sec16A OS=Homo sapiens GN=SEC16A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1913 Regucalcin gene promoter region-related protein (RGPR) Cluster-8309.42878 BF_2 77.66 0.65 5315 546673559 ERL85134.1 861 5.0e-89 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42879 BF_2 1205.23 14.60 3741 546673559 ERL85134.1 865 1.2e-89 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42885 BF_2 1188.90 16.30 3338 170032167 XP_001843954.1 1582 7.8e-173 conserved hypothetical protein [Culex quinquefasciatus]>gi|167871903|gb|EDS35286.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P30839 1294 8.0e-141 Fatty aldehyde dehydrogenase OS=Rattus norvegicus GN=Aldh3a2 PE=1 SV=1 PF00171 Aldehyde dehydrogenase family GO:0044710//GO:0008152//GO:0055114 single-organism metabolic process//metabolic process//oxidation-reduction process GO:0016620//GO:0016491 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.42886 BF_2 2614.23 27.98 4196 91079020 XP_974879.1 1901 1.0e-209 PREDICTED: staphylococcal nuclease domain-containing protein 1 [Tribolium castaneum]>gi|270003672|gb|EFA00120.1| hypothetical protein TcasGA2_TC002936 [Tribolium castaneum] -- -- -- -- -- K15979 SND1 staphylococcal nuclease domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15979 Q7ZT42 1171 1.8e-126 Staphylococcal nuclease domain-containing protein 1 OS=Danio rerio GN=snd1 PE=2 SV=1 -- -- GO:0031047 gene silencing by RNA GO:0003676//GO:0016788 nucleic acid binding//hydrolase activity, acting on ester bonds GO:0016442 RISC complex KOG2039 Transcriptional coactivator p100 Cluster-8309.42889 BF_2 840.17 10.79 3543 478250976 ENN71460.1 1089 1.2e-115 hypothetical protein YQE_11877, partial [Dendroctonus ponderosae]>gi|546682655|gb|ERL92567.1| hypothetical protein D910_09880 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P46941 324 2.5e-28 WW domain-containing protein tag-325 OS=Caenorhabditis elegans GN=tag-325 PE=3 SV=1 PF02749//PF00620 Quinolinate phosphoribosyl transferase, N-terminal domain//RhoGAP domain GO:0007165 signal transduction GO:0016763 transferase activity, transferring pentosyl groups -- -- KOG1450 Predicted Rho GTPase-activating protein Cluster-8309.42890 BF_2 158.64 3.67 2096 478259873 ENN79691.1 473 1.9e-44 hypothetical protein YQE_03871, partial [Dendroctonus ponderosae]>gi|478260329|gb|ENN80079.1| hypothetical protein YQE_03487, partial [Dendroctonus ponderosae]>gi|478266524|gb|ENN82814.1| hypothetical protein YQE_00818, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24799 267 6.1e-22 Myophilin OS=Echinococcus granulosus PE=2 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- KOG2046 Calponin Cluster-8309.42893 BF_2 4.45 95.59 215 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42895 BF_2 698.94 24.39 1486 546683208 ERL93048.1 494 5.0e-47 hypothetical protein D910_10350 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42897 BF_2 22.83 0.35 3023 642935831 XP_008198194.1 1680 3.1e-184 PREDICTED: rho guanine nucleotide exchange factor 10 isoform X2 [Tribolium castaneum] -- -- -- -- -- K16727 ARHGEF10 Rho guanine nucleotide exchange factor 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16727 Q8C033 370 1.0e-33 Rho guanine nucleotide exchange factor 10 OS=Mus musculus GN=Arhgef10 PE=2 SV=2 PF11770 GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021 integral component of membrane KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.4290 BF_2 4.00 0.42 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42900 BF_2 1024.35 14.12 3323 91093076 XP_968784.1 903 4.2e-94 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] 195036913 XM_001989877.1 35 5.26601e-06 Drosophila grimshawi GH18533 (Dgri\GH18533), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 844 1.2e-88 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.42901 BF_2 310.27 4.13 3427 642918312 XP_008191454.1 2864 0.0e+00 PREDICTED: nardilysin-like [Tribolium castaneum] 642918311 XM_008193232.1 116 5.09751e-51 PREDICTED: Tribolium castaneum nardilysin-like (LOC655191), mRNA K01411 NRD1 nardilysin http://www.genome.jp/dbget-bin/www_bget?ko:K01411 Q8BHG1 1917 4.7e-213 Nardilysin OS=Mus musculus GN=Nrd1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0959 N-arginine dibasic convertase NRD1 and related Zn2+-dependent endopeptidases, insulinase superfamily Cluster-8309.42903 BF_2 21.44 0.50 2075 270014138 EFA10586.1 919 3.7e-96 hypothetical protein TcasGA2_TC012843 [Tribolium castaneum] 642936569 XM_008200268.1 184 4.8507e-89 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC660007), transcript variant X2, mRNA -- -- -- -- P55202 325 1.1e-28 Atrial natriuretic peptide receptor 2 OS=Anguilla japonica GN=npr2 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.42904 BF_2 484.49 14.82 1655 332376633 AEE63456.1 1923 1.1e-212 unknown [Dendroctonus ponderosae] 195434135 XM_002065023.1 48 1.54054e-13 Drosophila willistoni GK15257 (Dwil\GK15257), mRNA -- -- -- -- Q96P53 1238 1.2e-134 WD repeat and FYVE domain-containing protein 2 OS=Homo sapiens GN=WDFY2 PE=2 SV=2 PF00400//PF07365//PF01363 WD domain, G-beta repeat//Alpha conotoxin precursor//FYVE zinc finger GO:0007268//GO:0009405//GO:0007165 synaptic transmission//pathogenesis//signal transduction GO:0030550//GO:0005515//GO:0046872 acetylcholine receptor inhibitor activity//protein binding//metal ion binding GO:0005576 extracellular region KOG1818 Membrane trafficking and cell signaling protein HRS, contains VHS and FYVE domains Cluster-8309.42905 BF_2 1741.00 66.16 1388 332373814 AEE62048.1 1915 7.9e-212 unknown [Dendroctonus ponderosae] 194896197 XM_001978396.1 323 1.72901e-166 Drosophila erecta GG17681 (Dere\GG17681), mRNA K03064 PSMC6, RPT4 26S proteasome regulatory subunit T4 http://www.genome.jp/dbget-bin/www_bget?ko:K03064 P62335 1794 3.5e-199 26S protease regulatory subunit 10B OS=Spermophilus tridecemlineatus GN=PSMC6 PE=2 SV=1 PF00004//PF13851//PF07724//PF01695//PF07728//PF05496//PF00158//PF06068//PF01432//PF00910//PF07726//PF02562//PF01637//PF02367 ATPase family associated with various cellular activities (AAA)//Growth-arrest specific micro-tubule binding//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain//TIP49 C-terminus//Peptidase family M3//RNA helicase//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006355//GO:0006281//GO:0002949//GO:0006310//GO:0006508//GO:0048870 regulation of transcription, DNA-templated//DNA repair//tRNA threonylcarbamoyladenosine modification//DNA recombination//proteolysis//cell motility GO:0016887//GO:0008134//GO:0005524//GO:0004222//GO:0009378//GO:0003724//GO:0003678//GO:0003723 ATPase activity//transcription factor binding//ATP binding//metalloendopeptidase activity//four-way junction helicase activity//RNA helicase activity//DNA helicase activity//RNA binding GO:0009379//GO:0031514//GO:0005667//GO:0005657 Holliday junction helicase complex//motile cilium//transcription factor complex//replication fork KOG0651 26S proteasome regulatory complex, ATPase RPT4 Cluster-8309.42907 BF_2 448.15 13.12 1716 86515410 NP_001034529.1 1464 1.9e-159 cytochrome P450, family 4, subfamily Q, polypeptide 4 precursor [Tribolium castaneum]>gi|7804914|gb|AAF70178.1|AF251548_1 cytochrome P450 monooxigenase CYP4Q4 [Tribolium castaneum] 826490357 XM_012684512.1 42 3.46025e-10 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105838744), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1024 8.3e-110 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016491//GO:0046872//GO:0016705 heme binding//iron ion binding//oxidoreductase activity//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42908 BF_2 35.24 0.79 2158 86515410 NP_001034529.1 1464 2.4e-159 cytochrome P450, family 4, subfamily Q, polypeptide 4 precursor [Tribolium castaneum]>gi|7804914|gb|AAF70178.1|AF251548_1 cytochrome P450 monooxigenase CYP4Q4 [Tribolium castaneum] 826490357 XM_012684512.1 42 4.37008e-10 PREDICTED: Monomorium pharaonis cytochrome P450 4C1-like (LOC105838744), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1024 1.0e-109 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0005506//GO:0020037//GO:0016705 metal ion binding//oxidoreductase activity//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.42909 BF_2 18.08 0.44 2018 91079304 XP_966317.1 1435 5.2e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 3.9e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.42911 BF_2 1193.00 23.33 2426 282158109 NP_001164098.1 2402 4.7e-268 heat shock protein TC005094 [Tribolium castaneum]>gi|270015405|gb|EFA11853.1| hypothetical protein TcasGA2_TC005094 [Tribolium castaneum] 113208384 AB251895.1 568 0 Mamestra brassicae hsp70 mRNA for heat shock protein 70, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 O97125 2184 3.7e-244 Heat shock protein 68 OS=Drosophila melanogaster GN=Hsp68 PE=1 SV=1 PF01968//PF06723 Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005524//GO:0016787 ATP binding//hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.42913 BF_2 1452.09 17.34 3791 478254766 ENN75003.1 1130 2.3e-120 hypothetical protein YQE_08460, partial [Dendroctonus ponderosae] 462318734 APGK01044304.1 89 5.76577e-36 Dendroctonus ponderosae Seq01044314, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF00158 Sigma-54 interaction domain GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0008134 ATP binding//transcription factor binding GO:0005667 transcription factor complex -- -- Cluster-8309.42915 BF_2 151.43 3.84 1938 546673062 ERL84739.1 613 1.0e-60 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 324 1.4e-28 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF01764//PF02230//PF07859//PF00326//PF03583//PF11112 Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family//Secretory lipase//Pyocin activator protein PrtN GO:0006629//GO:0008152//GO:0046486//GO:0006355//GO:0006508//GO:0016042 lipid metabolic process//metabolic process//glycerolipid metabolic process//regulation of transcription, DNA-templated//proteolysis//lipid catabolic process GO:0004806//GO:0016787//GO:0008236 triglyceride lipase activity//hydrolase activity//serine-type peptidase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.42917 BF_2 383.78 2.57 6523 332372760 AEE61522.1 509 4.0e-48 unknown [Dendroctonus ponderosae]>gi|478251664|gb|ENN72118.1| hypothetical protein YQE_11177, partial [Dendroctonus ponderosae]>gi|478262743|gb|ENN81274.1| hypothetical protein YQE_02310, partial [Dendroctonus ponderosae]>gi|546680918|gb|ERL91092.1| hypothetical protein D910_08434 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38718 366 6.3e-33 Mitochondrial pyruvate carrier 2 OS=Rattus norvegicus GN=Mpc2 PE=2 SV=1 PF03650//PF02790 Uncharacterised protein family (UPF0041)//Cytochrome C oxidase subunit II, transmembrane domain GO:0022900//GO:0006850 electron transport chain//mitochondrial pyruvate transport -- -- GO:0016021//GO:0005743 integral component of membrane//mitochondrial inner membrane KOG1589 Uncharacterized conserved protein Cluster-8309.42919 BF_2 2301.10 16.76 6031 642925932 XP_008194701.1 4700 0.0e+00 PREDICTED: protein son of sevenless [Tribolium castaneum] 642925931 XM_008196479.1 821 0 PREDICTED: Tribolium castaneum protein son of sevenless (LOC662194), mRNA K03099 SOS son of sevenless http://www.genome.jp/dbget-bin/www_bget?ko:K03099 P26675 3237 0.0e+00 Protein son of sevenless OS=Drosophila melanogaster GN=Sos PE=1 SV=2 PF00617//PF00032//PF00621//PF00125 RasGEF domain//Cytochrome b(C-terminal)/b6/petD//RhoGEF domain//Core histone H2A/H2B/H3/H4 GO:0035023//GO:0043087//GO:0006118//GO:0007264 regulation of Rho protein signal transduction//regulation of GTPase activity//obsolete electron transport//small GTPase mediated signal transduction GO:0003677//GO:0005085//GO:0016491//GO:0009055//GO:0005089 DNA binding//guanyl-nucleotide exchange factor activity//oxidoreductase activity//electron carrier activity//Rho guanyl-nucleotide exchange factor activity GO:0016020 membrane KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.42925 BF_2 40.73 5.80 581 646720584 KDR22245.1 138 3.7e-06 GMP reductase 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42928 BF_2 67.35 0.70 4313 91083607 XP_969406.1 899 1.6e-93 PREDICTED: solute carrier family 25 member 44 [Tribolium castaneum]>gi|270007841|gb|EFA04289.1| hypothetical protein TcasGA2_TC014580 [Tribolium castaneum] -- -- -- -- -- K15121 SLC25A44 solute carrier family 25, member 44 http://www.genome.jp/dbget-bin/www_bget?ko:K15121 Q5RD67 494 6.0e-48 Solute carrier family 25 member 44 OS=Pongo abelii GN=SLC25A44 PE=2 SV=2 PF00096 Zinc finger, C2H2 type GO:0055085 transmembrane transport GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG0765 Predicted mitochondrial carrier protein Cluster-8309.42929 BF_2 27.33 0.58 2255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668//PF05493 Aspartyl protease//ATP synthase subunit H GO:0015991//GO:0015992//GO:0006508 ATP hydrolysis coupled proton transport//proton transport//proteolysis GO:0015078//GO:0004190 hydrogen ion transmembrane transporter activity//aspartic-type endopeptidase activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.42930 BF_2 26.67 2.10 819 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09668 Aspartyl protease GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.42931 BF_2 982.05 4.55 9316 642926040 XP_008194740.1 10496 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 1035 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 P11029 7605 0.0e+00 Acetyl-CoA carboxylase OS=Gallus gallus GN=ACAC PE=1 SV=1 PF02655//PF02786//PF07478//PF08326 ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus//Acetyl-CoA carboxylase, central region GO:0006090//GO:0009252//GO:0006633//GO:0046436 pyruvate metabolic process//peptidoglycan biosynthetic process//fatty acid biosynthetic process//D-alanine metabolic process GO:0046872//GO:0003989//GO:0008716//GO:0005524 metal ion binding//acetyl-CoA carboxylase activity//D-alanine-D-alanine ligase activity//ATP binding GO:0009317 acetyl-CoA carboxylase complex KOG0368 Acetyl-CoA carboxylase Cluster-8309.42933 BF_2 618.79 10.92 2658 642911645 XP_008200684.1 1455 3.3e-158 PREDICTED: synapse-associated protein of 47 kDa isoform X1 [Tribolium castaneum]>gi|270014579|gb|EFA11027.1| hypothetical protein TcasGA2_TC004616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q960T2 565 2.2e-56 Synapse-associated protein of 47 kDa OS=Drosophila melanogaster GN=Sap47 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4310 Synapse-associated protein Cluster-8309.42934 BF_2 3.03 0.41 595 642911649 XP_008200687.1 208 2.9e-14 PREDICTED: synapse-associated protein of 47 kDa isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42936 BF_2 1019.86 15.27 3081 642926820 XP_008195027.1 2254 8.6e-251 PREDICTED: uncharacterized protein LOC100142170 isoform X2 [Tribolium castaneum]>gi|270008388|gb|EFA04836.1| hypothetical protein TcasGA2_TC014886 [Tribolium castaneum] 642926819 XM_008196805.1 319 6.50937e-164 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096//PF14719 Altered inheritance of mitochondria protein 3//Phosphotyrosine interaction domain (PTB/PID) GO:0051016 barbed-end actin filament capping GO:0005515 protein binding GO:0030479 actin cortical patch -- -- Cluster-8309.42937 BF_2 8.00 2.86 403 642923549 XP_008193554.1 545 1.7e-53 PREDICTED: zinc finger and SCAN domain-containing protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10073 293 1.1e-25 Zinc finger and SCAN domain-containing protein 22 OS=Homo sapiens GN=ZSCAN22 PE=1 SV=2 PF00096//PF05495//PF02892//PF00412//PF13912//PF13465//PF13639//PF07975 Zinc finger, C2H2 type//CHY zinc finger//BED zinc finger//LIM domain//C2H2-type zinc finger//Zinc-finger double domain//Ring finger domain//TFIIH C1-like domain GO:0006281 DNA repair GO:0046872//GO:0005515//GO:0008270//GO:0003677 metal ion binding//protein binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.42939 BF_2 203.46 3.21 2939 344241662 EGV97765.1 670 3.9e-67 Zinc finger protein 845, partial [Cricetulus griseus] 642923548 XM_008195332.1 36 1.2931e-06 PREDICTED: Tribolium castaneum zinc finger and SCAN domain-containing protein 2-like (LOC658870), transcript variant X2, mRNA -- -- -- -- P18753 552 7.7e-55 Oocyte zinc finger protein XlCOF8.4 (Fragment) OS=Xenopus laevis PE=2 SV=1 PF13465//PF00096//PF13912//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.42940 BF_2 81.75 1.39 2742 344241662 EGV97765.1 646 2.2e-64 Zinc finger protein 845, partial [Cricetulus griseus] 462390348 APGK01018839.1 38 9.31792e-08 Dendroctonus ponderosae Seq01018849, whole genome shotgun sequence K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9BY31 525 9.7e-52 Zinc finger protein 717 OS=Homo sapiens GN=ZNF717 PE=2 SV=2 PF13912//PF07776//PF13465//PF00096//PF07975 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.42941 BF_2 12.00 0.33 1805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00738 Polyhedrin -- -- GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.42943 BF_2 112.97 0.47 10262 642912029 XP_008199066.1 2816 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: patched domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0EEE2 345 2.7e-30 Patched domain-containing protein 3 OS=Mus musculus GN=Ptchd3 PE=1 SV=1 PF04319//PF02460//PF03176//PF00873 NifZ domain//Patched family//MMPL family//AcrB/AcrD/AcrF family GO:0006810//GO:0007165//GO:0009399 transport//signal transduction//nitrogen fixation GO:0005215//GO:0008158 transporter activity//hedgehog receptor activity GO:0016020 membrane -- -- Cluster-8309.42947 BF_2 1341.07 5.04 11419 91093513 XP_969441.1 4135 0.0e+00 PREDICTED: RNA polymerase-associated protein CTR9 homolog [Tribolium castaneum]>gi|270002675|gb|EEZ99122.1| hypothetical protein TcasGA2_TC005228 [Tribolium castaneum] 759065906 XM_011344092.1 655 0 PREDICTED: Cerapachys biroi RNA polymerase-associated protein CTR9 homolog (LOC105282240), mRNA K15176 CTR9 RNA polymerase-associated protein CTR9 http://www.genome.jp/dbget-bin/www_bget?ko:K15176 Q4QR29 3306 0.0e+00 RNA polymerase-associated protein CTR9 homolog OS=Xenopus laevis GN=ctr9 PE=2 SV=1 PF00892//PF13174//PF05009//PF06027//PF07721//PF13181//PF10579//PF13176//PF05887//PF13414//PF00515//PF13374 EamA-like transporter family//Tetratricopeptide repeat//Epstein-Barr virus nuclear antigen 3 (EBNA-3)//Solute carrier family 35//Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Procyclic acidic repetitive protein (PARP)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006810//GO:0007268//GO:0016032 transport//synaptic transmission//viral process GO:0043495//GO:0005515//GO:0033130//GO:0042802 protein anchor//protein binding//acetylcholine receptor binding//identical protein binding GO:0016020//GO:0042025//GO:0016021 membrane//host cell nucleus//integral component of membrane KOG2002 TPR-containing nuclear phosphoprotein that regulates K(+) uptake Cluster-8309.42950 BF_2 77.95 0.59 5801 642936624 XP_008198511.1 2966 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X3 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.17895e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.9e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF02346//PF01166 Chordopoxvirus multifunctional envelope protein A27//TSC-22/dip/bun family GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.42951 BF_2 63.16 0.65 4331 642924482 XP_008194314.1 222 5.1e-15 PREDICTED: protein ELYS isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05210 Sprouty protein (Spry) GO:0007275//GO:0009966 multicellular organismal development//regulation of signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.42952 BF_2 1556.20 48.16 1639 282403505 NP_001164149.1 1680 1.7e-184 fumble isoform 2 [Tribolium castaneum]>gi|642912443|ref|XP_008200862.1| PREDICTED: fumble isoform X2 [Tribolium castaneum] 746854770 XM_011059724.1 126 6.65888e-57 PREDICTED: Acromyrmex echinatior pantothenate kinase 3 (LOC105148170), transcript variant X9, mRNA K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q8TE04 1160 1.4e-125 Pantothenate kinase 1 OS=Homo sapiens GN=PANK1 PE=1 SV=2 PF03630 Fumble GO:0015937//GO:0015940 coenzyme A biosynthetic process//pantothenate biosynthetic process GO:0004594//GO:0005524 pantothenate kinase activity//ATP binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.42954 BF_2 1277.75 5.50 10007 546685894 ERL95319.1 2308 1.5e-256 hypothetical protein D910_12585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MSS1 521 1.0e-50 Protein lava lamp OS=Drosophila melanogaster GN=lva PE=1 SV=2 PF06463 Molybdenum Cofactor Synthesis C GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0051539 4 iron, 4 sulfur cluster binding GO:0019008 molybdopterin synthase complex -- -- Cluster-8309.42956 BF_2 539.35 7.32 3368 642928849 XP_008195587.1 3047 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 16 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15159 MED16 mediator of RNA polymerase II transcription subunit 16 http://www.genome.jp/dbget-bin/www_bget?ko:K15159 Q16K67 1494 5.2e-164 Mediator of RNA polymerase II transcription subunit 16 OS=Aedes aegypti GN=MED16 PE=3 SV=1 PF00830 Ribosomal L28 family GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.42957 BF_2 96.49 0.86 4961 642931172 XP_008196469.1 1949 3.2e-215 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42958 BF_2 224.41 1.07 9099 189238003 XP_969912.2 3006 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925068|ref|XP_008194156.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925070|ref|XP_008194157.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|270008050|gb|EFA04498.1| hypothetical protein TcasGA2_TC014806 [Tribolium castaneum] 642925074 XM_008195937.1 248 5.69799e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 252 1.5e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF00096//PF13465//PF04988//PF02196//PF00715//PF05792 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//Raf-like Ras-binding domain//Interleukin 2//Candida agglutinin-like (ALS) GO:0007165//GO:0040007//GO:0008283//GO:0006955//GO:0007155 signal transduction//growth//cell proliferation//immune response//cell adhesion GO:0003677//GO:0005057//GO:0008083//GO:0046872//GO:0005134 DNA binding//receptor signaling protein activity//growth factor activity//metal ion binding//interleukin-2 receptor binding GO:0005634//GO:0005576//GO:0005893 nucleus//extracellular region//interleukin-2 receptor complex -- -- Cluster-8309.42959 BF_2 69.41 0.45 6786 642931369 XP_008196550.1 7220 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931368 XM_008198328.1 1020 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X6, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5900 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF10390//PF07353//PF05014//PF05171//PF00498//PF00225//PF00959 RNA polymerase II elongation factor ELL//Uroplakin II//Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//FHA domain//Kinesin motor domain//Phage lysozyme GO:0016998//GO:0006368//GO:0006206//GO:0007018//GO:0009253//GO:0009159//GO:0061024//GO:0007017//GO:0006826//GO:0005975 cell wall macromolecule catabolic process//transcription elongation from RNA polymerase II promoter//pyrimidine nucleobase metabolic process//microtubule-based movement//peptidoglycan catabolic process//deoxyribonucleoside monophosphate catabolic process//membrane organization//microtubule-based process//iron ion transport//carbohydrate metabolic process GO:0070694//GO:0003796//GO:0005515//GO:0003777//GO:0008017//GO:0005524//GO:0050144 deoxyribonucleoside 5'-monophosphate N-glycosidase activity//lysozyme activity//protein binding//microtubule motor activity//microtubule binding//ATP binding//nucleoside deoxyribosyltransferase activity GO:0008023//GO:0030176//GO:0005874//GO:0045298 transcription elongation factor complex//integral component of endoplasmic reticulum membrane//microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.4296 BF_2 264.41 4.33 2844 642921677 XP_008192920.1 1071 1.2e-113 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 393 2.0e-36 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.42960 BF_2 26.87 0.47 2680 91092368 XP_971937.1 1294 1.6e-139 PREDICTED: dnaJ homolog dnj-5 [Tribolium castaneum] -- -- -- -- -- K09534 DNAJC14 DnaJ homolog subfamily C member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K09534 Q921R4 425 3.7e-40 DnaJ homolog subfamily C member 14 OS=Mus musculus GN=Dnajc14 PE=2 SV=2 PF09726//PF05390 Transmembrane protein//Yeast cell wall synthesis protein KRE9/KNH1 GO:0042546//GO:0006078 cell wall biogenesis//(1->6)-beta-D-glucan biosynthetic process -- -- GO:0016021 integral component of membrane KOG0720 Molecular chaperone (DnaJ superfamily) Cluster-8309.42962 BF_2 573.48 9.33 2859 642927489 XP_008195288.1 1569 2.2e-171 PREDICTED: neuropilin and tolloid-like protein 1 [Tribolium castaneum] 642927488 XM_008197066.1 249 4.93683e-125 PREDICTED: Tribolium castaneum neuropilin and tolloid-like protein 1 (LOC658952), mRNA -- -- -- -- Q8NC67 400 3.2e-37 Neuropilin and tolloid-like protein 2 OS=Homo sapiens GN=NETO2 PE=1 SV=1 PF02535//PF00057//PF00430//PF01956 ZIP Zinc transporter//Low-density lipoprotein receptor domain class A//ATP synthase B/B' CF(0)//Integral membrane protein DUF106 GO:0055085//GO:0030001//GO:0015986//GO:0015992 transmembrane transport//metal ion transport//ATP synthesis coupled proton transport//proton transport GO:0005515//GO:0015078//GO:0046873 protein binding//hydrogen ion transmembrane transporter activity//metal ion transmembrane transporter activity GO:0016020//GO:0045263 membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.42963 BF_2 106.45 1.00 4756 728418761 AIY68380.1 1519 2.2e-165 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 709 7.8e-73 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF13499//PF01153//PF13405//PF13833//PF12763//PF08115//PF00036//PF03874//PF00326//PF13202//PF07859 EF-hand domain pair//Glypican//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//SFI toxin family//EF hand//RNA polymerase Rpb4//Prolyl oligopeptidase family//EF hand//alpha/beta hydrolase fold GO:0009405//GO:0006144//GO:0008152//GO:0006351//GO:0006206//GO:0006508 pathogenesis//purine nucleobase metabolic process//metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//proteolysis GO:0003899//GO:0043395//GO:0016787//GO:0008236//GO:0005515//GO:0005509 DNA-directed RNA polymerase activity//heparan sulfate proteoglycan binding//hydrolase activity//serine-type peptidase activity//protein binding//calcium ion binding GO:0005730//GO:0005578//GO:0005576//GO:0016020 nucleolus//proteinaceous extracellular matrix//extracellular region//membrane -- -- Cluster-8309.42964 BF_2 5.37 1.47 439 91091742 XP_966408.1 334 5.3e-29 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 276 1.2e-23 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 -- -- GO:0008152 metabolic process GO:0030170//GO:0008483 pyridoxal phosphate binding//transaminase activity -- -- KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.42965 BF_2 570.98 2.59 9515 91091742 XP_966408.1 1295 4.2e-139 PREDICTED: alanine--glyoxylate aminotransferase 2-like [Tribolium castaneum]>gi|270001093|gb|EEZ97540.1| hypothetical protein TcasGA2_TC011390 [Tribolium castaneum] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 953 7.9e-101 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF05372//PF00202//PF03431//PF02424 Delta lysin family//Aminotransferase class-III//RNA replicase, beta-chain//ApbE family GO:0019079//GO:0008152//GO:0017013//GO:0006144//GO:0019836 viral genome replication//metabolic process//protein flavinylation//purine nucleobase metabolic process//hemolysis by symbiont of host erythrocytes GO:0030170//GO:0008483//GO:0003968 pyridoxal phosphate binding//transaminase activity//RNA-directed RNA polymerase activity GO:0005576//GO:0031379 extracellular region//RNA-directed RNA polymerase complex KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.42967 BF_2 258.57 2.25 5101 642915075 XP_008190400.1 5163 0.0e+00 PREDICTED: unconventional myosin-IXa isoform X1 [Tribolium castaneum]>gi|642915077|ref|XP_008190401.1| PREDICTED: unconventional myosin-IXa isoform X1 [Tribolium castaneum]>gi|270002356|gb|EEZ98803.1| hypothetical protein TcasGA2_TC001372 [Tribolium castaneum] 768442001 XM_011564452.1 512 0 PREDICTED: Plutella xylostella unconventional myosin-IXa-like (LOC105392773), mRNA K10360 MYO9 myosin IX http://www.genome.jp/dbget-bin/www_bget?ko:K10360 Q63358 2222 3.0e-248 Unconventional myosin-IXb OS=Rattus norvegicus GN=Myo9b PE=1 SV=1 PF00788//PF00437//PF09280//PF02954//PF15177//PF00612//PF00063 Ras association (RalGDS/AF-6) domain//Type II/IV secretion system protein//XPC-binding domain//Bacterial regulatory protein, Fis family//Interleukin-28A//IQ calmodulin-binding motif//Myosin head (motor domain) GO:0035556//GO:0007165//GO:0006810//GO:0006281//GO:0043161//GO:0006289//GO:0007259//GO:0050778//GO:0051607 intracellular signal transduction//signal transduction//transport//DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair//JAK-STAT cascade//positive regulation of immune response//defense response to virus GO:0005125//GO:0043565//GO:0005524//GO:0003774//GO:0046872//GO:0003684//GO:0005515 cytokine activity//sequence-specific DNA binding//ATP binding//motor activity//metal ion binding//damaged DNA binding//protein binding GO:0016459 myosin complex KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.42968 BF_2 26.41 18.26 342 642912471 XP_008200876.1 298 6.1e-25 PREDICTED: transcription elongation regulator 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 141 4.1e-08 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862//PF06459 DDHD domain//Ryanodine Receptor TM 4-6 GO:0006816//GO:0006874 calcium ion transport//cellular calcium ion homeostasis GO:0005219//GO:0046872 ryanodine-sensitive calcium-release channel activity//metal ion binding GO:0016021//GO:0005622 integral component of membrane//intracellular KOG0155 Transcription factor CA150 Cluster-8309.42969 BF_2 1475.86 35.32 2035 642916336 XP_008190980.1 1473 2.1e-160 PREDICTED: rab11 family-interacting protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12485 RAB11FIP3_4 Rab11 family-interacting protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K12485 Q86YS3 404 7.7e-38 Rab11 family-interacting protein 4 OS=Homo sapiens GN=RAB11FIP4 PE=1 SV=1 PF08653//PF05557 DASH complex subunit Dam1//Mitotic checkpoint protein GO:0008608//GO:0007094 attachment of spindle microtubules to kinetochore//mitotic spindle assembly checkpoint -- -- GO:0042729//GO:0072686 DASH complex//mitotic spindle KOG0982 Centrosomal protein Nuf Cluster-8309.42971 BF_2 514.00 4.33 5257 642930931 XP_008196146.1 2320 3.3e-258 PREDICTED: ephrin type-A receptor 4-B isoform X2 [Tribolium castaneum] 642930930 XM_008197924.1 475 0 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P54755 1396 1.9e-152 Ephrin type-A receptor 5 OS=Gallus gallus GN=EPHA5 PE=2 SV=1 PF07731//PF06293//PF16656//PF00041//PF00069//PF07714//PF00536//PF04587//PF05434//PF07647 Multicopper oxidase//Lipopolysaccharide kinase (Kdo/WaaP) family//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase//SAM domain (Sterile alpha motif)//ADP-specific Phosphofructokinase/Glucokinase conserved region//TMEM9//SAM domain (Sterile alpha motif) GO:0005975//GO:0055114//GO:0006771//GO:0019497//GO:0006468 carbohydrate metabolic process//oxidation-reduction process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0046872//GO:0004672//GO:0003993//GO:0016773//GO:0016491//GO:0005515//GO:0005507//GO:0005524 metal ion binding//protein kinase activity//acid phosphatase activity//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity//protein binding//copper ion binding//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.42973 BF_2 24.13 0.87 1441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42977 BF_2 244.47 6.78 1795 332374794 AEE62538.1 980 2.7e-103 unknown [Dendroctonus ponderosae]>gi|546674015|gb|ERL85508.1| hypothetical protein D910_02927 [Dendroctonus ponderosae] -- -- -- -- -- K01444 AGA, aspG N4-(beta-N-acetylglucosaminyl)-L-asparaginase http://www.genome.jp/dbget-bin/www_bget?ko:K01444 O02467 840 1.9e-88 N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase (Fragment) OS=Spodoptera frugiperda PE=1 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1593 Asparaginase Cluster-8309.42979 BF_2 112.72 13.67 632 478255719 ENN75928.1 637 5.6e-64 hypothetical protein YQE_07465, partial [Dendroctonus ponderosae]>gi|546681163|gb|ERL91307.1| hypothetical protein D910_08639 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35502 169 4.3e-11 Esterase FE4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.42980 BF_2 302.00 2.86 4711 270013440 EFA09888.1 842 7.1e-87 hypothetical protein TcasGA2_TC012037 [Tribolium castaneum] -- -- -- -- -- K08497 SEC20 protein transport protein SEC20 http://www.genome.jp/dbget-bin/www_bget?ko:K08497 Q12981 377 2.4e-34 Vesicle transport protein SEC20 OS=Homo sapiens GN=BNIP1 PE=1 SV=3 PF13890//PF03836//PF04513 Rab3 GTPase-activating protein catalytic subunit//RasGAP C-terminus//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007264 small GTPase mediated signal transduction GO:0005096//GO:0005198 GTPase activator activity//structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope -- -- Cluster-8309.42981 BF_2 51.69 1.49 1737 91087645 XP_973337.1 594 1.5e-58 PREDICTED: homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein [Tribolium castaneum]>gi|270010715|gb|EFA07163.1| hypothetical protein TcasGA2_TC010160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BSE4 296 2.2e-25 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein OS=Homo sapiens GN=HERPUD2 PE=1 SV=2 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG4583 Membrane-associated ER protein involved in stress response (contains ubiquitin-like domain) Cluster-8309.42982 BF_2 75.11 1.44 2474 642923462 XP_008193755.1 945 4.2e-99 PREDICTED: forkhead box protein L2-like isoform X1 [Tribolium castaneum] 507561117 XM_004664203.1 146 7.71738e-68 PREDICTED: Jaculus jaculus forkhead box L2 (Foxl2), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 O88470 395 1.0e-36 Forkhead box protein L2 OS=Mus musculus GN=Foxl2 PE=1 SV=2 PF00250//PF06070 Forkhead domain//Herpesvirus large structural phosphoprotein UL32 GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700//GO:0005198 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//structural molecule activity GO:0005667 transcription factor complex -- -- Cluster-8309.42983 BF_2 1519.11 13.35 5049 642924854 XP_008194067.1 5142 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein mahjong [Tribolium castaneum] 662191784 XM_008470499.1 80 7.75206e-31 PREDICTED: Diaphorina citri protein mahjong (LOC103506118), mRNA K11789 VPRBP, DCAF1 HIV-1 Vpr-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11789 Q9Y4B6 2635 3.8e-296 Protein VPRBP OS=Homo sapiens GN=VPRBP PE=1 SV=3 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG1832 HIV-1 Vpr-binding protein Cluster-8309.42984 BF_2 59.32 0.37 7043 642928264 XP_969418.2 1140 3.0e-121 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q8BQR4 470 6.0e-45 KAT8 regulatory NSL complex subunit 2 OS=Mus musculus GN=Kansl2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.42985 BF_2 504.90 2.21 9864 478250015 ENN70521.1 3990 0.0e+00 hypothetical protein YQE_12697, partial [Dendroctonus ponderosae] 658876389 XM_008422979.1 108 4.13514e-46 PREDICTED: Poecilia reticulata unconventional myosin-Ig-like (LOC103473050), mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23978 2850 0.0e+00 Myosin-IA OS=Drosophila melanogaster GN=Myo31DF PE=2 SV=1 PF00612//PF00063//PF06414//PF00437//PF06017 IQ calmodulin-binding motif//Myosin head (motor domain)//Zeta toxin//Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding GO:0006810 transport GO:0003774//GO:0016301//GO:0005524//GO:0005515 motor activity//kinase activity//ATP binding//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.42986 BF_2 152.57 0.96 6944 91077500 XP_969314.1 3436 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.06023e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2060 2.5e-229 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF08446//PF07544//PF00588//PF06009 PAS fold//RNA polymerase II transcription mediator complex subunit 9//SpoU rRNA Methylase family//Laminin Domain II GO:0006396//GO:0006357//GO:0007155//GO:0006355//GO:0009451 RNA processing//regulation of transcription from RNA polymerase II promoter//cell adhesion//regulation of transcription, DNA-templated//RNA modification GO:0008173//GO:0003723//GO:0001104 RNA methyltransferase activity//RNA binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.42988 BF_2 101.00 2.91 1739 91090820 XP_971545.1 1658 6.3e-182 PREDICTED: heparan sulfate glucosamine 3-O-sulfotransferase 1 [Tribolium castaneum] 198456690 XM_001360374.2 94 4.34879e-39 Drosophila pseudoobscura pseudoobscura GA17321 (Dpse\GA17321), partial mRNA K08104 HS3ST5 http://www.genome.jp/dbget-bin/www_bget?ko:K08104 Q8IZT8 772 1.4e-80 Heparan sulfate glucosamine 3-O-sulfotransferase 5 OS=Homo sapiens GN=HS3ST5 PE=1 SV=1 PF00685//PF03567//PF04947 Sulfotransferase domain//Sulfotransferase family//Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription GO:0008146 sulfotransferase activity GO:0016021 integral component of membrane KOG3704 Heparan sulfate D-glucosaminyl 3-O-sulfotransferase Cluster-8309.42989 BF_2 587.83 8.34 3237 270001944 EEZ98391.1 2260 1.8e-251 hypothetical protein TcasGA2_TC000855 [Tribolium castaneum] 755966655 XM_011307270.1 318 2.46113e-163 PREDICTED: Fopius arisanus disks large 1 tumor suppressor protein (LOC105268032), transcript variant X5, mRNA K12075 DLG2_3 discs large protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12075 P31007 1822 4.6e-202 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF14604//PF00595//PF00018//PF13180 Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.42991 BF_2 1292.70 15.77 3717 189237356 XP_969548.2 2743 2.1e-307 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 817080180 XM_012407117.1 207 1.43342e-101 PREDICTED: Athalia rosae transmembrane 9 superfamily member 2 (LOC105689811), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q66HG5 2133 4.6e-238 Transmembrane 9 superfamily member 2 OS=Rattus norvegicus GN=Tm9sf2 PE=2 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.42992 BF_2 1205.45 14.39 3792 189237356 XP_969548.2 2743 2.1e-307 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 817080180 XM_012407117.1 207 1.46263e-101 PREDICTED: Athalia rosae transmembrane 9 superfamily member 2 (LOC105689811), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q66HG5 2133 4.7e-238 Transmembrane 9 superfamily member 2 OS=Rattus norvegicus GN=Tm9sf2 PE=2 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.42994 BF_2 1.84 7.80 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.42995 BF_2 102.00 0.77 5807 817087169 XP_012266348.1 531 1.0e-50 PREDICTED: CUGBP Elav-like family member 2 isoform X2 [Athalia rosae] 194861276 XM_001969711.1 74 1.93176e-27 Drosophila erecta GG23780 (Dere\GG23780), mRNA K13207 CUGBP, BRUNOL, CELF CUG-BP- and ETR3-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13207 Q5R8Y8 377 3.0e-34 CUGBP Elav-like family member 2 OS=Pongo abelii GN=CELF2 PE=2 SV=2 PF00076//PF15320//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//mRNA cap methylation, RNMT-activating mini protein//RNA recognition motif GO:0032259 methylation GO:0003676//GO:0003723 nucleic acid binding//RNA binding GO:0005845 mRNA cap binding complex KOG0144 RNA-binding protein CUGBP1/BRUNO (RRM superfamily) Cluster-8309.42998 BF_2 129.05 1.11 5152 642917797 XP_008191290.1 2204 9.0e-245 PREDICTED: NAD-dependent histone deacetylase Sir2 [Tribolium castaneum]>gi|270003357|gb|EEZ99804.1| hypothetical protein TcasGA2_TC002584 [Tribolium castaneum] -- -- -- -- -- K11411 SIRT1, SIR2L1 NAD-dependent deacetylase sirtuin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11411 Q9VK34 1115 7.0e-120 NAD-dependent histone deacetylase Sir2 OS=Drosophila melanogaster GN=Sir2 PE=1 SV=1 PF00205//PF04574//PF02146 Thiamine pyrophosphate enzyme, central domain//Protein of unknown function (DUF592)//Sir2 family GO:0006807//GO:0006355//GO:0006342//GO:0006476 nitrogen compound metabolic process//regulation of transcription, DNA-templated//chromatin silencing//protein deacetylation GO:0030976//GO:0000287//GO:0008270//GO:0051287//GO:0070403//GO:0017136//GO:0016811 thiamine pyrophosphate binding//magnesium ion binding//zinc ion binding//NAD binding//NAD+ binding//NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0000118 histone deacetylase complex KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family) Cluster-8309.42999 BF_2 1559.25 27.69 2643 546685535 ERL95022.1 492 1.5e-46 hypothetical protein D910_12292 [Dendroctonus ponderosae] 449102215 JX081307.1 150 4.93149e-70 Pleurobrachia bachei dynein light chain-2 mRNA, complete cds K10418 DYNLL dynein light chain LC8-type http://www.genome.jp/dbget-bin/www_bget?ko:K10418 Q78P75 465 8.5e-45 Dynein light chain 2, cytoplasmic OS=Rattus norvegicus GN=Dynll2 PE=1 SV=1 PF01221 Dynein light chain type 1 GO:0007017 microtubule-based process -- -- GO:0005875 microtubule associated complex KOG3430 Dynein light chain type 1 Cluster-8309.43000 BF_2 104.37 1.45 3302 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 6.44147e-40 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 1.4e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.43001 BF_2 2747.90 27.98 4395 91091728 XP_967315.1 1628 4.8e-178 PREDICTED: argininosuccinate synthase [Tribolium castaneum]>gi|270001069|gb|EEZ97516.1| hypothetical protein TcasGA2_TC011361 [Tribolium castaneum] 78496741 CP000153.1 36 1.94165e-06 Sulfurimonas denitrificans DSM 1251, complete genome K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 Q0IFL5 1380 1.1e-150 Argininosuccinate synthase OS=Aedes aegypti GN=AAEL004701 PE=3 SV=1 PF00764//PF00498 Arginosuccinate synthase//FHA domain GO:0006531//GO:0006560//GO:0006526//GO:0006522 aspartate metabolic process//proline metabolic process//arginine biosynthetic process//alanine metabolic process GO:0004055//GO:0005515//GO:0005524 argininosuccinate synthase activity//protein binding//ATP binding -- -- KOG1706 Argininosuccinate synthase Cluster-8309.43004 BF_2 14.00 1.16 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43005 BF_2 264.32 1.92 6036 91086459 XP_969641.1 1106 2.2e-117 PREDICTED: phytanoyl-CoA dioxygenase, peroxisomal-like [Tribolium castaneum] -- -- -- -- -- K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 P57093 721 4.0e-74 Phytanoyl-CoA dioxygenase, peroxisomal OS=Rattus norvegicus GN=Phyh PE=1 SV=2 PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.43006 BF_2 90.26 0.84 4776 478255274 ENN75503.1 1875 1.2e-206 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF00057 Sulfatase//Low-density lipoprotein receptor domain class A GO:0008152 metabolic process GO:0005515//GO:0008484 protein binding//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.43007 BF_2 80.47 2.81 1486 91089625 XP_973443.1 909 3.8e-95 PREDICTED: tudor and KH domain-containing protein [Tribolium castaneum]>gi|270012611|gb|EFA09059.1| hypothetical protein TcasGA2_TC006774 [Tribolium castaneum] -- -- -- -- -- K18406 TDRKH, TDRD2 tudor domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18406 Q80VL1 431 4.2e-41 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 -- -- -- -- GO:0003723 RNA binding -- -- KOG2039 Transcriptional coactivator p100 Cluster-8309.43009 BF_2 45.19 0.49 4174 642924249 XP_966647.3 1292 4.1e-139 PREDICTED: palmitoyltransferase ZDHHC18 [Tribolium castaneum] -- -- -- -- -- K16675 ZDHHC9_14_18 palmitoyltransferase ZDHHC9/14/18 http://www.genome.jp/dbget-bin/www_bget?ko:K16675 Q8BQQ1 1009 1.1e-107 Probable palmitoyltransferase ZDHHC14 OS=Mus musculus GN=Zdhhc14 PE=2 SV=1 PF13520//PF05493//PF03699//PF01529//PF02419 Amino acid permease//ATP synthase subunit H//Uncharacterised protein family (UPF0182)//DHHC palmitoyltransferase//PsbL protein GO:0003333//GO:0015992//GO:0015979//GO:0006865//GO:0015991 amino acid transmembrane transport//proton transport//photosynthesis//amino acid transport//ATP hydrolysis coupled proton transport GO:0015078//GO:0008270//GO:0015171 hydrogen ion transmembrane transporter activity//zinc ion binding//amino acid transmembrane transporter activity GO:0016020//GO:0009523//GO:0009539//GO:0033179//GO:0016021 membrane//photosystem II//photosystem II reaction center//proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG1311 DHHC-type Zn-finger proteins Cluster-8309.43010 BF_2 1049.64 17.68 2770 546682290 ERL92248.1 263 5.7e-20 hypothetical protein D910_09565 [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q86GF7 192 4.0e-13 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382//PF06662 RTX N-terminal domain//D-glucuronyl C5-epimerase C-terminus GO:0006024//GO:0009405 glycosaminoglycan biosynthetic process//pathogenesis GO:0016857//GO:0005509 racemase and epimerase activity, acting on carbohydrates and derivatives//calcium ion binding GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.43014 BF_2 3.96 0.40 705 642913083 XP_008201383.1 736 2.1e-75 PREDICTED: disks large 1 tumor suppressor protein isoform X7 [Tribolium castaneum] 642913082 XM_008203161.1 259 3.24163e-131 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X7, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 321 1.1e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.43015 BF_2 11.45 0.34 1689 91080235 XP_972829.1 164 1.1e-08 PREDICTED: caprin homolog [Tribolium castaneum]>gi|270005626|gb|EFA02074.1| hypothetical protein TcasGA2_TC007709 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13520 Amino acid permease GO:0003333//GO:0006865 amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.43016 BF_2 595.00 13.09 2189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43018 BF_2 2.00 0.56 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43020 BF_2 448.45 8.57 2477 270003943 EFA00391.1 1322 8.2e-143 hypothetical protein TcasGA2_TC003237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULV3 169 1.7e-10 Cip1-interacting zinc finger protein OS=Homo sapiens GN=CIZ1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43021 BF_2 129.93 1.77 3353 91089975 XP_973865.1 663 2.9e-66 PREDICTED: glycolipid transfer protein [Tribolium castaneum]>gi|270013545|gb|EFA09993.1| hypothetical protein TcasGA2_TC012160 [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 D3ZY60 238 2.3e-18 Pleckstrin homology domain-containing family A member 8 OS=Rattus norvegicus GN=Plekha8 PE=1 SV=1 PF08718 Glycolipid transfer protein (GLTP) GO:0046836 glycolipid transport GO:0051861//GO:0017089 glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG3221 Glycolipid transfer protein Cluster-8309.43024 BF_2 2795.00 67.16 2028 642910328 XP_008200285.1 1747 3.5e-192 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270014917|gb|EFA11365.1| hypothetical protein TcasGA2_TC011522 [Tribolium castaneum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 1459 3.6e-160 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0008152//GO:0006633//GO:0042967 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0004315//GO:0016491//GO:0016747//GO:0016297 3-oxoacyl-[acyl-carrier-protein] synthase activity//oxidoreductase activity//transferase activity, transferring acyl groups other than amino-acyl groups//acyl-[acyl-carrier-protein] hydrolase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.43025 BF_2 455.00 10.72 2063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43027 BF_2 6.05 1.64 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.43028 BF_2 5672.85 48.72 5158 91094043 XP_968570.1 5338 0.0e+00 PREDICTED: peroxidasin [Tribolium castaneum]>gi|270004795|gb|EFA01243.1| peroxidasin [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q9VZZ4 3408 0.0e+00 Peroxidasin OS=Drosophila melanogaster GN=Pxn PE=1 SV=1 PF13895//PF07354//PF02480//PF13855//PF09728 Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Alphaherpesvirus glycoprotein E//Leucine rich repeat//Myosin-like coiled-coil protein GO:0007339//GO:0006804//GO:0006979//GO:0055114 binding of sperm to zona pellucida//obsolete peroxidase reaction//response to oxidative stress//oxidation-reduction process GO:0019905//GO:0005515//GO:0004601//GO:0020037 syntaxin binding//protein binding//peroxidase activity//heme binding GO:0005576//GO:0016020 extracellular region//membrane KOG2408 Peroxidase/oxygenase Cluster-8309.43031 BF_2 574.59 8.09 3257 157130405 XP_001655700.1 449 1.8e-41 AAEL002600-PA [Aedes aegypti]>gi|108881960|gb|EAT46185.1| AAEL002600-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- P27435 282 1.7e-23 Tryptase OS=Rattus norvegicus GN=Tpsab1 PE=1 SV=2 PF16048//PF11057//PF00089 Frog antimicrobial peptide//Cortexin of kidney//Trypsin GO:0006508//GO:0006952 proteolysis//defense response GO:0004252 serine-type endopeptidase activity GO:0005576//GO:0031224 extracellular region//intrinsic component of membrane -- -- Cluster-8309.43033 BF_2 245.19 3.32 3378 134131322 BAF49604.1 1104 2.1e-117 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 517 1.0e-50 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00704//PF00089 Glycosyl hydrolases family 18//Trypsin GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004252 hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type endopeptidase activity -- -- KOG2806 Chitinase Cluster-8309.43035 BF_2 645.40 4.58 6181 642923131 XP_008193622.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 3 isoform X1 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.2e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF00989//PF00010//PF08447 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- -- -- Cluster-8309.43037 BF_2 385.17 4.17 4147 642926286 XP_008194862.1 2720 1.1e-304 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like [Tribolium castaneum] 642926285 XM_008196640.1 270 1.52352e-136 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1584 2.3e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF00069//PF01392//PF07714 Protein kinase domain//Fz domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.43038 BF_2 729.45 4.22 7513 642939202 XP_008200380.1 3478 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 168 1.39291e-79 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1288 8.9e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF01825//PF02793//PF02140//PF02617//PF00002//PF03547 GPCR proteolysis site, GPS, motif//Hormone receptor domain//Galactose binding lectin domain//ATP-dependent Clp protease adaptor protein ClpS//7 transmembrane receptor (Secretin family)//Membrane transport protein GO:0030163//GO:0055085//GO:0007186 protein catabolic process//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0030246 G-protein coupled receptor activity//carbohydrate binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.43040 BF_2 1120.34 6.50 7499 642922218 XP_008193066.1 916 3.0e-95 PREDICTED: TBC1 domain family member 24 isoform X3 [Tribolium castaneum] 768435492 XM_011560896.1 107 1.12933e-45 PREDICTED: Plutella xylostella TBC1 domain family member 24 (LOC105389728), transcript variant X5, mRNA -- -- -- -- Q9ULP9 328 1.9e-28 TBC1 domain family member 24 OS=Homo sapiens GN=TBC1D24 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.43041 BF_2 70.96 0.39 7941 642922218 XP_008193066.1 660 1.5e-65 PREDICTED: TBC1 domain family member 24 isoform X3 [Tribolium castaneum] 768435492 XM_011560896.1 74 2.64492e-27 PREDICTED: Plutella xylostella TBC1 domain family member 24 (LOC105389728), transcript variant X5, mRNA -- -- -- -- Q08CX5 283 3.2e-23 TBC1 domain family member 24 OS=Xenopus tropicalis GN=tbc1d24 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2801 Probable Rab-GAPs Cluster-8309.43042 BF_2 1319.18 7.60 7544 642922218 XP_008193066.1 916 3.0e-95 PREDICTED: TBC1 domain family member 24 isoform X3 [Tribolium castaneum] 768435492 XM_011560896.1 107 1.13614e-45 PREDICTED: Plutella xylostella TBC1 domain family member 24 (LOC105389728), transcript variant X5, mRNA -- -- -- -- Q9ULP9 328 1.9e-28 TBC1 domain family member 24 OS=Homo sapiens GN=TBC1D24 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.43043 BF_2 16.82 0.46 1803 91095059 XP_972457.1 767 1.3e-78 PREDICTED: uroporphyrinogen decarboxylase [Tribolium castaneum] -- -- -- -- -- K01599 hemE, UROD uroporphyrinogen decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01599 Q9V595 590 1.9e-59 Uroporphyrinogen decarboxylase OS=Drosophila melanogaster GN=Updo PE=3 SV=1 PF01208 Uroporphyrinogen decarboxylase (URO-D) GO:0015994//GO:0006779 chlorophyll metabolic process//porphyrin-containing compound biosynthetic process GO:0004853 uroporphyrinogen decarboxylase activity -- -- KOG2872 Uroporphyrinogen decarboxylase Cluster-8309.43044 BF_2 661.40 8.36 3598 91078392 XP_974372.1 1555 1.1e-169 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270003986|gb|EFA00434.1| hypothetical protein TcasGA2_TC003288 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 594 1.3e-59 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.43050 BF_2 133.41 4.31 1583 91091790 XP_970226.1 1209 6.6e-130 PREDICTED: mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A-like isoform X1 [Tribolium castaneum] 512883118 XM_002943445.2 41 1.14606e-09 PREDICTED: Xenopus (Silurana) tropicalis mannosidase, alpha, class 1A, member 2 (man1a2), mRNA K01230 MAN1 mannosyl-oligosaccharide alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01230 P53624 636 7.5e-65 Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform A OS=Drosophila melanogaster GN=alpha-Man-I PE=1 SV=2 PF01532 Glycosyl hydrolase family 47 GO:0005975 carbohydrate metabolic process GO:0004571//GO:0005509 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity//calcium ion binding GO:0016020 membrane KOG2204 Mannosyl-oligosaccharide alpha-1,2-mannosidase and related glycosyl hydrolases Cluster-8309.43051 BF_2 571.89 4.02 6239 282721016 NP_001164208.1 2490 7.5e-278 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 409 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 9.4e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF12937//PF01557//PF00646//PF12125//PF00400//PF15324 F-box-like//Fumarylacetoacetate (FAA) hydrolase family//F-box domain//D domain of beta-TrCP//WD domain, G-beta repeat//Hedgehog signalling target GO:0007224//GO:0008152 smoothened signaling pathway//metabolic process GO:0003824//GO:0046983//GO:0005515 catalytic activity//protein dimerization activity//protein binding -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.43052 BF_2 299.70 2.16 6100 282721016 NP_001164208.1 2490 7.3e-278 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 9.2e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF01557//PF12937//PF15324//PF00646//PF12125//PF00400 Fumarylacetoacetate (FAA) hydrolase family//F-box-like//Hedgehog signalling target//F-box domain//D domain of beta-TrCP//WD domain, G-beta repeat GO:0007224//GO:0008152 smoothened signaling pathway//metabolic process GO:0003824//GO:0005515//GO:0046983 catalytic activity//protein binding//protein dimerization activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.43053 BF_2 54.51 0.60 4103 91088055 XP_967186.1 1358 9.1e-147 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 94 1.03762e-38 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q2NL29 1146 1.4e-123 Inositol-3-phosphate synthase 1 OS=Bos taurus GN=ISYNA1 PE=2 SV=1 PF13912//PF07994//PF13762 C2H2-type zinc finger//Myo-inositol-1-phosphate synthase//Mitochondrial splicing apparatus component GO:0006021//GO:0000372//GO:0019872//GO:0008654 inositol biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//phospholipid biosynthetic process GO:0004512//GO:0046872//GO:0000166 inositol-3-phosphate synthase activity//metal ion binding//nucleotide binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.43054 BF_2 1767.32 14.94 5237 642934874 XP_008197845.1 2625 1.4e-293 PREDICTED: ecdysone-induced protein 75B, isoforms C/D isoform X4 [Tribolium castaneum] 443682249 KC020244.1 254 1.51126e-127 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1308 3.0e-142 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4846 Nuclear receptor Cluster-8309.43056 BF_2 67.60 0.48 6119 642917305 XP_008199244.1 5286 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X5 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3646 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF17096//PF02710//PF00501 DMAP1-binding Domain//Altered inheritance of mitochondria protein 3//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//AMP-binding enzyme GO:0051016//GO:0007165//GO:0008152//GO:0019064 barbed-end actin filament capping//signal transduction//metabolic process//fusion of virus membrane with host plasma membrane GO:0046789//GO:0016788//GO:0003824//GO:0008134 host cell surface receptor binding//hydrolase activity, acting on ester bonds//catalytic activity//transcription factor binding GO:0009986//GO:0030479//GO:0005634//GO:0019031//GO:0005667 cell surface//actin cortical patch//nucleus//viral envelope//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.43057 BF_2 274.85 7.51 1818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43059 BF_2 208.32 2.49 3790 642936594 XP_008198499.1 1421 4.1e-154 PREDICTED: solute carrier family 2, facilitated glucose transporter member 1-like isoform X2 [Tribolium castaneum]>gi|270014149|gb|EFA10597.1| hypothetical protein TcasGA2_TC012857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13355 670 2.1e-68 Solute carrier family 2, facilitated glucose transporter member 1 OS=Oryctolagus cuniculus GN=SLC2A1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.43062 BF_2 345.29 17.12 1131 91078844 XP_971675.1 520 3.7e-50 PREDICTED: leucine-rich repeat-containing protein 59 [Tribolium castaneum]>gi|270003717|gb|EFA00165.1| hypothetical protein TcasGA2_TC002987 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9X4 323 1.1e-28 Leucine-rich repeat-containing protein 59 OS=Bos taurus GN=LRRC59 PE=2 SV=1 PF03985//PF03040//PF00560//PF11744//PF01956//PF04998//PF13855 Paf1//CemA family//Leucine Rich Repeat//Aluminium activated malate transporter//Integral membrane protein DUF106//RNA polymerase Rpb1, domain 5//Leucine rich repeat GO:0006351//GO:0006368//GO:0006144//GO:0015743//GO:0016570//GO:0006206 transcription, DNA-templated//transcription elongation from RNA polymerase II promoter//purine nucleobase metabolic process//malate transport//histone modification//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0005515 DNA binding//DNA-directed RNA polymerase activity//protein binding GO:0016593//GO:0016021//GO:0016020//GO:0005730 Cdc73/Paf1 complex//integral component of membrane//membrane//nucleolus KOG0619 FOG: Leucine rich repeat Cluster-8309.43063 BF_2 153.38 2.09 3350 189238741 XP_972079.2 3193 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927110|ref|XP_008195141.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927112|ref|XP_008195142.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum]>gi|642927115|ref|XP_008195143.1| PREDICTED: ubiquitin carboxyl-terminal hydrolase 20 [Tribolium castaneum] 699256288 XM_009863644.1 39 3.17283e-08 PREDICTED: Ciona intestinalis ubiquitin carboxyl-terminal hydrolase 20-like (LOC100184024), mRNA K11848 USP20_33 ubiquitin carboxyl-terminal hydrolase 20/33 http://www.genome.jp/dbget-bin/www_bget?ko:K11848 A0JM59 1233 9.5e-134 Ubiquitin carboxyl-terminal hydrolase 20 OS=Xenopus tropicalis GN=usp20 PE=2 SV=1 PF02148//PF17001//PF06337//PF00443 Zn-finger in ubiquitin-hydrolases and other protein//Type III secretion basal body protein I, YscI, HrpB, PscI//DUSP domain//Ubiquitin carboxyl-terminal hydrolase GO:0006508//GO:0016579//GO:0009306 proteolysis//protein deubiquitination//protein secretion GO:0004843//GO:0036459//GO:0008270 ubiquitin-specific protease activity//ubiquitinyl hydrolase activity//zinc ion binding -- -- KOG1870 Ubiquitin C-terminal hydrolase Cluster-8309.43064 BF_2 230.49 1.05 9430 642930696 XP_008199991.1 1575 1.4e-171 PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930698|ref|XP_008199992.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|642930700|ref|XP_008199993.1| PREDICTED: aldehyde dehydrogenase, dimeric NADP-preferring-like [Tribolium castaneum]>gi|270012671|gb|EFA09119.1| hypothetical protein TcasGA2_TC015979 [Tribolium castaneum] -- -- -- -- -- K00128 E1.2.1.3 aldehyde dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K00128 P11883 1236 1.2e-133 Aldehyde dehydrogenase, dimeric NADP-preferring OS=Rattus norvegicus GN=Aldh3a1 PE=1 SV=3 PF08656//PF01370//PF00106//PF07690//PF00171//PF02558 DASH complex subunit Dad3//NAD dependent epimerase/dehydratase family//short chain dehydrogenase//Major Facilitator Superfamily//Aldehyde dehydrogenase family//Ketopantoate reductase PanE/ApbA GO:0008152//GO:0006081//GO:0006547//GO:0006570//GO:0006096//GO:0015940//GO:0055085//GO:0055114//GO:0008608//GO:0006094//GO:0006558 metabolic process//cellular aldehyde metabolic process//histidine metabolic process//tyrosine metabolic process//glycolytic process//pantothenate biosynthetic process//transmembrane transport//oxidation-reduction process//attachment of spindle microtubules to kinetochore//gluconeogenesis//L-phenylalanine metabolic process GO:0016491//GO:0003824//GO:0004030//GO:0008677//GO:0050662 oxidoreductase activity//catalytic activity//aldehyde dehydrogenase [NAD(P)+] activity//2-dehydropantoate 2-reductase activity//coenzyme binding GO:0072686//GO:0016021//GO:0042729 mitotic spindle//integral component of membrane//DASH complex KOG2456 Aldehyde dehydrogenase Cluster-8309.43066 BF_2 355.12 3.54 4488 642914155 XP_008201569.1 5162 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 15 isoform X3 [Tribolium castaneum]>gi|270001582|gb|EEZ98029.1| hypothetical protein TcasGA2_TC000430 [Tribolium castaneum] -- -- -- -- -- K04426 MAP3K5, ASK1 mitogen-activated protein kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04426 Q6ZN16 2571 9.0e-289 Mitogen-activated protein kinase kinase kinase 15 OS=Homo sapiens GN=MAP3K15 PE=1 SV=2 PF00069//PF07714//PF07647 Protein kinase domain//Protein tyrosine kinase//SAM domain (Sterile alpha motif) GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005515//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//protein binding//ATP binding -- -- KOG4279 Serine/threonine protein kinase Cluster-8309.43067 BF_2 948.99 12.22 3536 270014368 EFA10816.1 549 5.0e-53 hypothetical protein TcasGA2_TC030657 [Tribolium castaneum] -- -- -- -- -- K18588 COQ10 coenzyme Q-binding protein COQ10 http://www.genome.jp/dbget-bin/www_bget?ko:K18588 Q6DFA6 389 7.4e-36 Coenzyme Q-binding protein COQ10 homolog A, mitochondrial OS=Xenopus laevis GN=coq10b-a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3177 Oligoketide cyclase/lipid transport protein Cluster-8309.43069 BF_2 425.40 6.69 2947 91083661 XP_975782.1 3160 0.0e+00 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 2200 6.2e-246 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF07992//PF00036//PF12831//PF01266//PF13499//PF13833//PF13405//PF01134 Pyridine nucleotide-disulphide oxidoreductase//EF hand//FAD dependent oxidoreductase//FAD dependent oxidoreductase//EF-hand domain pair//EF-hand domain pair//EF-hand domain//Glucose inhibited division protein A GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0016491//GO:0005509//GO:0050660 oxidoreductase activity//calcium ion binding//flavin adenine dinucleotide binding -- -- KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.43073 BF_2 561.64 8.62 3012 642919036 XP_008191706.1 1793 2.4e-197 PREDICTED: uncharacterized protein LOC663686 isoform X2 [Tribolium castaneum] 749755207 XM_011141773.1 86 2.12604e-34 PREDICTED: Harpegnathos saltator uncharacterized LOC105183546 (LOC105183546), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43075 BF_2 1052.35 19.41 2555 270001418 EEZ97865.1 1466 1.7e-159 hypothetical protein TcasGA2_TC000237 [Tribolium castaneum] 642914800 XM_008192137.1 546 0 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X3, mRNA K13162 PCBP2_3_4 poly(rC)-binding protein 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13162 P57721 735 4.0e-76 Poly(rC)-binding protein 3 OS=Homo sapiens GN=PCBP3 PE=2 SV=2 PF00013//PF06326//PF13014//PF13184//PF07650 KH domain//Vesiculovirus matrix protein//KH domain//NusA-like KH domain//KH domain -- -- GO:0003723//GO:0005198 RNA binding//structural molecule activity GO:0019031 viral envelope KOG2190 PolyC-binding proteins alphaCP-1 and related KH domain proteins Cluster-8309.43076 BF_2 1440.55 17.02 3827 -- -- -- -- -- 642914805 XM_008192139.1 52 2.15371e-15 PREDICTED: Tribolium castaneum poly(rC)-binding protein 3 (LOC658107), transcript variant X6, mRNA -- -- -- -- -- -- -- -- PF06990 Galactose-3-O-sulfotransferase GO:0009058//GO:0006687 biosynthetic process//glycosphingolipid metabolic process GO:0001733 galactosylceramide sulfotransferase activity GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane -- -- Cluster-8309.43077 BF_2 884.00 22.05 1964 642931096 XP_974337.3 729 3.7e-74 PREDICTED: serine protease persephone-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWU1 501 4.2e-49 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.43078 BF_2 165.18 0.99 7291 91082383 XP_968748.1 2378 8.5e-265 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.15359e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1618 4.7e-178 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00931//PF00005//PF03193//PF01637//PF06414//PF00437//PF02224//PF00664//PF01926//PF13304 NB-ARC domain//ABC transporter//Protein of unknown function, DUF258//Archaeal ATPase//Zeta toxin//Type II/IV secretion system protein//Cytidylate kinase//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006206//GO:0055085//GO:0006810//GO:0006139 pyrimidine nucleobase metabolic process//transmembrane transport//transport//nucleobase-containing compound metabolic process GO:0016301//GO:0016887//GO:0004127//GO:0005525//GO:0017111//GO:0042626//GO:0005524//GO:0003924//GO:0043531 kinase activity//ATPase activity//cytidylate kinase activity//GTP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//ADP binding GO:0016021 integral component of membrane -- -- Cluster-8309.4308 BF_2 4.00 0.67 537 642924239 XP_008194212.1 469 1.4e-44 PREDICTED: neuroligin-1 [Tribolium castaneum] 642924238 XM_008195990.1 161 7.30312e-77 PREDICTED: Tribolium castaneum neuroligin 2 (LOC663865), mRNA -- -- -- -- Q5XG92 140 8.3e-08 Carboxylesterase 4A OS=Homo sapiens GN=CES4A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.43082 BF_2 22.73 0.99 1245 642913599 XP_008201080.1 169 2.0e-09 PREDICTED: extensin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43084 BF_2 22.51 0.39 2713 546678005 ERL88729.1 1301 2.4e-140 hypothetical protein D910_06111 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BNA9 1005 2.1e-107 CCR4-NOT transcription complex subunit 11 OS=Rattus norvegicus GN=Cnot11 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43085 BF_2 39.49 1.18 1693 91089543 XP_971483.1 801 1.4e-82 PREDICTED: uncharacterized protein LOC660130 isoform X1 [Tribolium castaneum] 642933375 XM_966390.2 173 5.136e-83 PREDICTED: Tribolium castaneum uncharacterized LOC660130 (LOC660130), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF00822//PF00335//PF13903//PF06687 PMP-22/EMP/MP20/Claudin family//Tetraspanin family//PMP-22/EMP/MP20/Claudin tight junction//SUR7/PalI family -- -- -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.43087 BF_2 538.16 10.32 2469 642932818 XP_008196998.1 3141 0.0e+00 PREDICTED: protein CLEC16A isoform X6 [Tribolium castaneum] -- -- -- -- -- K19513 CLEC16A protein CLEC16A http://www.genome.jp/dbget-bin/www_bget?ko:K19513 Q2KHT3 1236 3.1e-134 Protein CLEC16A OS=Homo sapiens GN=CLEC16A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2219 Uncharacterized conserved protein Cluster-8309.43088 BF_2 200.58 1.23 7105 478254018 ENN74310.1 6594 0.0e+00 hypothetical protein YQE_09281, partial [Dendroctonus ponderosae] 242005974 XM_002423790.1 223 3.50928e-110 Pediculus humanus corporis jumonji/arid domain-containing protein, putative, mRNA K11446 KDM5, JARID1 histone demethylase JARID1 http://www.genome.jp/dbget-bin/www_bget?ko:K11446 Q9VMJ7 3561 0.0e+00 Lysine-specific demethylase lid OS=Drosophila melanogaster GN=lid PE=1 SV=1 PF00628//PF01388//PF08429 PHD-finger//ARID/BRIGHT DNA binding domain//PLU-1-like protein GO:0055114 oxidation-reduction process GO:0016706//GO:0003677//GO:0005515 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//DNA binding//protein binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.43090 BF_2 206.92 3.54 2732 478259045 ENN78988.1 1984 1.6e-219 hypothetical protein YQE_04539, partial [Dendroctonus ponderosae] 640815149 XM_008066140.1 74 9.02446e-28 PREDICTED: Tarsius syrichta peroxisomal biogenesis factor 6 (PEX6), transcript variant X2, mRNA K13339 PEX6, PXAAA1 peroxin-6 http://www.genome.jp/dbget-bin/www_bget?ko:K13339 Q99LC9 1138 8.0e-123 Peroxisome assembly factor 2 OS=Mus musculus GN=Pex6 PE=2 SV=1 PF14532//PF01695//PF07728//PF05496//PF01057//PF06068//PF00158//PF00004//PF07724//PF07726//PF02562//PF02367//PF00910 Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Parvovirus non-structural protein NS1//TIP49 C-terminus//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0019079//GO:0006281//GO:0002949//GO:0006355//GO:0006310 viral genome replication//DNA repair//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA recombination GO:0005524//GO:0003678//GO:0003723//GO:0008134//GO:0016887//GO:0009378//GO:0003724 ATP binding//DNA helicase activity//RNA binding//transcription factor binding//ATPase activity//four-way junction helicase activity//RNA helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain Cluster-8309.43093 BF_2 4.00 0.86 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43096 BF_2 239.11 0.98 10447 642914280 XP_008201619.1 1367 2.1e-147 PREDICTED: cyclic AMP-dependent transcription factor ATF-6 beta [Tribolium castaneum] 332375533 BT127946.1 81 4.47442e-31 Dendroctonus ponderosae clone DPO1025_H21 unknown mRNA K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q6GM78 703 8.5e-72 Isoaspartyl peptidase/L-asparaginase OS=Xenopus laevis GN=asrgl1 PE=2 SV=1 PF01112//PF16622//PF13465//PF03453//PF04977//PF04275//PF14861//PF07776//PF01166//PF03131//PF13912//PF12356//PF07716//PF06156//PF00096//PF00170//PF06005 Asparaginase//zinc-finger C2H2-type//Zinc-finger double domain//MoeA N-terminal region (domain I and II)//Septum formation initiator//Phosphomevalonate kinase//Plant antimicrobial peptide//Zinc-finger associated domain (zf-AD)//TSC-22/dip/bun family//bZIP Maf transcription factor//C2H2-type zinc finger//Protein of unknown function (DUF3643)//Basic region leucine zipper//Protein of unknown function (DUF972)//Zinc finger, C2H2 type//bZIP transcription factor//Protein of unknown function (DUF904) GO:0032465//GO:0050832//GO:0006915//GO:0007049//GO:0006694//GO:0006260//GO:0006355//GO:0016567//GO:0032324//GO:0000917//GO:0043093//GO:0006695 regulation of cytokinesis//defense response to fungus//apoptotic process//cell cycle//steroid biosynthetic process//DNA replication//regulation of transcription, DNA-templated//protein ubiquitination//molybdopterin cofactor biosynthetic process//barrier septum assembly//FtsZ-dependent cytokinesis//cholesterol biosynthetic process GO:0016787//GO:0003700//GO:0004631//GO:0043565//GO:0008270//GO:0004842//GO:0003677//GO:0046872 hydrolase activity//transcription factor activity, sequence-specific DNA binding//phosphomevalonate kinase activity//sequence-specific DNA binding//zinc ion binding//ubiquitin-protein transferase activity//DNA binding//metal ion binding GO:0005737//GO:0005667//GO:0005634 cytoplasm//transcription factor complex//nucleus KOG1592 Asparaginase Cluster-8309.43097 BF_2 1717.76 23.34 3366 642913378 XP_008195461.1 2341 7.7e-261 PREDICTED: uncharacterized protein LOC657396 isoform X2 [Tribolium castaneum]>gi|270002028|gb|EEZ98475.1| hypothetical protein TcasGA2_TC000967 [Tribolium castaneum] 195480065 XM_002101088.1 119 1.07593e-52 Drosophila yakuba GE15793 (Dyak\GE15793), partial mRNA -- -- -- -- -- -- -- -- PF01853//PF01048 MOZ/SAS family//Phosphorylase superfamily GO:0009116//GO:0006355 nucleoside metabolic process//regulation of transcription, DNA-templated GO:0003824//GO:0016747 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.43101 BF_2 63.00 23.91 396 194354011 NP_001123895.1 405 2.8e-37 cytochrome P450 CYP9Z1 [Tribolium castaneum]>gi|270012791|gb|EFA09239.1| cytochrome P450 9Z1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 306 3.5e-27 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0046872//GO:0016705 heme binding//oxidoreductase activity//iron ion binding//metal ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.43103 BF_2 764.05 24.05 1616 189236728 XP_974937.2 906 9.2e-95 PREDICTED: ATP-dependent (S)-NAD(P)H-hydrate dehydratase [Tribolium castaneum] -- -- -- -- -- K17757 CARKD ATP-dependent NAD(P)H-hydrate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K17757 E3XDZ8 662 7.4e-68 ATP-dependent (S)-NAD(P)H-hydrate dehydratase OS=Anopheles darlingi GN=AND_21715 PE=3 SV=1 PF01256 Carbohydrate kinase -- -- GO:0052855 ADP-dependent NAD(P)H-hydrate dehydratase activity -- -- KOG3974 Predicted sugar kinase Cluster-8309.43104 BF_2 703.00 19.61 1787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04514 Bluetongue virus non-structural protein NS2 -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.4311 BF_2 2.21 0.39 522 642911511 XP_008199453.1 276 3.3e-22 PREDICTED: protein unc-79 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43110 BF_2 580.80 16.19 1788 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43111 BF_2 43.99 0.65 3122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43113 BF_2 50.00 0.68 3355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06373 Cocaine and amphetamine regulated transcript protein (CART) GO:0008343//GO:0009267//GO:0001678//GO:0007186//GO:0000186//GO:0032099 adult feeding behavior//cellular response to starvation//cellular glucose homeostasis//G-protein coupled receptor signaling pathway//activation of MAPKK activity//negative regulation of appetite -- -- GO:0005615 extracellular space -- -- Cluster-8309.43114 BF_2 612.53 6.84 4032 642924664 XP_008194387.1 1401 9.2e-152 PREDICTED: tensin isoform X13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43116 BF_2 415.74 2.25 8027 91077984 XP_968658.1 1315 1.7e-141 PREDICTED: serine protease 42 [Tribolium castaneum]>gi|270002734|gb|EEZ99181.1| serine protease H2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VIF2 364 1.3e-32 Serine protease 42 OS=Mus musculus GN=Prss42 PE=2 SV=1 PF09284//PF03184//PF05393//PF00089 Rhamnogalacturonan lyase B, N-terminal//DDE superfamily endonuclease//Human adenovirus early E3A glycoprotein//Trypsin GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004252//GO:0016837//GO:0030246//GO:0003676 serine-type endopeptidase activity//carbon-oxygen lyase activity, acting on polysaccharides//carbohydrate binding//nucleic acid binding GO:0016021 integral component of membrane -- -- Cluster-8309.43119 BF_2 640.11 38.99 974 546678053 ERL88777.1 630 5.6e-63 hypothetical protein D910_06159 [Dendroctonus ponderosae] -- -- -- -- -- K01934 MTHFS 5-formyltetrahydrofolate cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01934 Q9D110 447 3.8e-43 5-formyltetrahydrofolate cyclo-ligase OS=Mus musculus GN=Mthfs PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3093 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.43120 BF_2 37.19 1.11 1684 546684777 ERL94372.1 764 2.8e-78 hypothetical protein D910_11652 [Dendroctonus ponderosae] -- -- -- -- -- K01613 psd, PISD phosphatidylserine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01613 Q9UG56 516 6.6e-51 Phosphatidylserine decarboxylase proenzyme OS=Homo sapiens GN=PISD PE=2 SV=4 PF02666 Phosphatidylserine decarboxylase GO:0006544//GO:0046486//GO:0008654//GO:0006566//GO:0006563 glycine metabolic process//glycerolipid metabolic process//phospholipid biosynthetic process//threonine metabolic process//L-serine metabolic process GO:0004609 phosphatidylserine decarboxylase activity -- -- KOG2420 Phosphatidylserine decarboxylase Cluster-8309.43121 BF_2 25.36 0.34 3450 642913416 XP_008201002.1 2426 1.1e-270 PREDICTED: supernumerary limbs isoform X2 [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 5.2e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF12937//PF15324//PF00400//PF12125//PF00646 F-box-like//Hedgehog signalling target//WD domain, G-beta repeat//D domain of beta-TrCP//F-box domain GO:0007224 smoothened signaling pathway GO:0046983//GO:0005515 protein dimerization activity//protein binding -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.43122 BF_2 1111.48 8.44 5795 642925926 XP_008194700.1 6572 0.0e+00 PREDICTED: tetratricopeptide repeat protein 28 [Tribolium castaneum] 347968281 XM_312278.5 861 0 Anopheles gambiae str. PEST AGAP002648-PA (AgaP_AGAP002648) mRNA, complete cds -- -- -- -- Q96AY4 4208 0.0e+00 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 PF13414//PF13176//PF00515//PF13374//PF10255//PF13181//PF07721//PF10579 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RNA polymerase I-associated factor PAF67//Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region GO:0007268//GO:0006446 synaptic transmission//regulation of translational initiation GO:0043495//GO:0005515//GO:0042802//GO:0033130//GO:0003743 protein anchor//protein binding//identical protein binding//acetylcholine receptor binding//translation initiation factor activity GO:0005852//GO:0005737//GO:0005840 eukaryotic translation initiation factor 3 complex//cytoplasm//ribosome KOG0548 Molecular co-chaperone STI1 Cluster-8309.43123 BF_2 48.33 0.58 3783 189237356 XP_969548.2 2710 1.4e-303 PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|642923199|ref|XP_008193652.1| PREDICTED: transmembrane 9 superfamily member 2 [Tribolium castaneum]>gi|270007091|gb|EFA03539.1| hypothetical protein TcasGA2_TC013542 [Tribolium castaneum] 817080180 XM_012407117.1 207 1.45912e-101 PREDICTED: Athalia rosae transmembrane 9 superfamily member 2 (LOC105689811), transcript variant X2, mRNA K17086 TM9SF2_4 transmembrane 9 superfamily member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K17086 Q66HG5 2100 3.1e-234 Transmembrane 9 superfamily member 2 OS=Rattus norvegicus GN=Tm9sf2 PE=2 SV=1 PF02990 Endomembrane protein 70 -- -- -- -- GO:0016021 integral component of membrane KOG1278 Endosomal membrane proteins, EMP70 Cluster-8309.43128 BF_2 2.00 0.67 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43131 BF_2 2334.76 30.90 3448 478253971 ENN74263.1 1931 2.7e-213 hypothetical protein YQE_09235, partial [Dendroctonus ponderosae] -- -- -- -- -- K08189 SLC16A13 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K08189 Q7RTY0 334 1.7e-29 Monocarboxylate transporter 13 OS=Homo sapiens GN=SLC16A13 PE=2 SV=1 PF05924//PF00473//PF07690 SAMP Motif//Corticotropin-releasing factor family//Major Facilitator Superfamily GO:0055085//GO:0016055//GO:0007165 transmembrane transport//Wnt signaling pathway//signal transduction GO:0005179//GO:0008013 hormone activity//beta-catenin binding GO:0016021//GO:0016342//GO:0005576 integral component of membrane//catenin complex//extracellular region KOG2504 Monocarboxylate transporter Cluster-8309.43132 BF_2 51.93 0.38 6055 642935990 XP_008198259.1 3666 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1110 3.1e-119 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.43135 BF_2 727.72 3.85 8204 642932579 XP_008196910.1 4293 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.88203e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1947 3.7e-216 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF00443//PF00569//PF08496//PF02723//PF12678//PF02148//PF14634//PF17122//PF00097//PF01165//PF00637//PF13639//PF09726//PF12861 Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type//Peptidase family S49 N-terminal//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//zinc-RING finger domain//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Ribosomal protein S21//Region in Clathrin and VPS//Ring finger domain//Transmembrane protein//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0006412//GO:0016567//GO:0006886//GO:0016192//GO:0016579//GO:0042254 translation//protein ubiquitination//intracellular protein transport//vesicle-mediated transport//protein deubiquitination//ribosome biogenesis GO:0005515//GO:0004842//GO:0046872//GO:0036459//GO:0004252//GO:0003735//GO:0008270 protein binding//ubiquitin-protein transferase activity//metal ion binding//ubiquitinyl hydrolase activity//serine-type endopeptidase activity//structural constituent of ribosome//zinc ion binding GO:0005680//GO:0005886//GO:0016020//GO:0016021//GO:0005840 anaphase-promoting complex//plasma membrane//membrane//integral component of membrane//ribosome KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.43136 BF_2 114.98 0.61 8215 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 177 1.51296e-84 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF09726//PF12861//PF00637//PF01165//PF13639//PF05680//PF00097//PF17122//PF02148//PF02723//PF12678//PF14634//PF08496//PF00443//PF00569 Transmembrane protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Region in Clathrin and VPS//Ribosomal protein S21//Ring finger domain//ATP synthase E chain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger//Zn-finger in ubiquitin-hydrolases and other protein//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//zinc-RING finger domain//Peptidase family S49 N-terminal//Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type GO:0015992//GO:0042254//GO:0016579//GO:0016192//GO:0006886//GO:0015986//GO:0016567//GO:0006412 proton transport//ribosome biogenesis//protein deubiquitination//vesicle-mediated transport//intracellular protein transport//ATP synthesis coupled proton transport//protein ubiquitination//translation GO:0008270//GO:0003735//GO:0015078//GO:0004252//GO:0036459//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//structural constituent of ribosome//hydrogen ion transmembrane transporter activity//serine-type endopeptidase activity//ubiquitinyl hydrolase activity//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005840//GO:0016021//GO:0000276//GO:0016020//GO:0005886//GO:0005680 ribosome//integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//membrane//plasma membrane//anaphase-promoting complex KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.4314 BF_2 7.00 0.61 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43140 BF_2 2505.20 11.18 9659 642937913 XP_972695.3 1638 7.3e-179 PREDICTED: uncharacterized protein LOC661447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AJA9 380 2.2e-34 Uncharacterized protein C9orf172 homolog OS=Mus musculus GN=Gm996 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43142 BF_2 516.83 6.08 3845 91076698 XP_971949.1 3939 0.0e+00 PREDICTED: dipeptidyl peptidase 9 [Tribolium castaneum] -- -- -- -- -- K08656 DPP9 dipeptidyl-peptidase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08656 Q86TI2 1788 4.8e-198 Dipeptidyl peptidase 9 OS=Homo sapiens GN=DPP9 PE=1 SV=3 PF00326//PF07859//PF02230//PF13954//PF02129//PF01738//PF00930 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//PapC N-terminal domain//X-Pro dipeptidyl-peptidase (S15 family)//Dienelactone hydrolase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236//GO:0005515 hydrolase activity//serine-type peptidase activity//protein binding -- -- KOG2281 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases Cluster-8309.43144 BF_2 322.00 5.94 2555 91088613 XP_973949.1 1834 3.6e-202 PREDICTED: pseudouridylate synthase 7 homolog [Tribolium castaneum]>gi|270011693|gb|EFA08141.1| hypothetical protein TcasGA2_TC005758 [Tribolium castaneum] -- -- -- -- -- K06176 truD, PUS7 tRNA pseudouridine13 synthase http://www.genome.jp/dbget-bin/www_bget?ko:K06176 Q96PZ0 995 2.9e-106 Pseudouridylate synthase 7 homolog OS=Homo sapiens GN=PUS7 PE=1 SV=2 PF01142 tRNA pseudouridine synthase D (TruD) GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG2339 Uncharacterized conserved protein Cluster-8309.43145 BF_2 169.10 1.56 4816 330371797 AEC12819.1 1380 3.0e-149 lactate dehydrogenase [Litopenaeus vannamei]>gi|385211791|gb|AFI47930.1| L-lactate dehydrogenase isoform 2 [Litopenaeus vannamei] 262401152 FJ774758.1 534 0 Scylla paramamosain l-lactate dehydrogenase mRNA, partial cds K00016 LDH, ldh L-lactate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00016 Q95028 1178 3.3e-127 L-lactate dehydrogenase OS=Drosophila melanogaster GN=ImpL3 PE=2 SV=1 PF02056//PF00056//PF02866 Family 4 glycosyl hydrolase//lactate/malate dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, alpha/beta C-terminal domain GO:0055114//GO:0005975//GO:0006094//GO:0044262//GO:0006534//GO:0006096 oxidation-reduction process//carbohydrate metabolic process//gluconeogenesis//cellular carbohydrate metabolic process//cysteine metabolic process//glycolytic process GO:0000166//GO:0016616//GO:0016491//GO:0004553//GO:0004459 nucleotide binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//L-lactate dehydrogenase activity GO:0005737 cytoplasm KOG1495 Lactate dehydrogenase Cluster-8309.43146 BF_2 517.91 18.12 1483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43148 BF_2 89.52 3.94 1238 642930888 XP_008196127.1 152 1.9e-07 PREDICTED: uncharacterized protein LOC658955 isoform X7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43149 BF_2 152.78 0.70 9421 91083997 XP_975257.1 1901 2.3e-209 PREDICTED: phosphatidate cytidylyltransferase, photoreceptor-specific [Tribolium castaneum]>gi|270007993|gb|EFA04441.1| hypothetical protein TcasGA2_TC014743 [Tribolium castaneum] 729297249 XM_010548190.1 40 2.49717e-08 PREDICTED: Tarenaya hassleriana phosphatidate cytidylyltransferase (LOC104818548), transcript variant X5, mRNA K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 1615 1.4e-177 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 PF13639//PF05485//PF14604//PF00018//PF12906//PF12678 Ring finger domain//THAP domain//Variant SH3 domain//SH3 domain//RING-variant domain//RING-H2 zinc finger GO:0016024//GO:0008654//GO:0046486 CDP-diacylglycerol biosynthetic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0008270//GO:0003676//GO:0004605//GO:0005515 zinc ion binding//nucleic acid binding//phosphatidate cytidylyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1440 CDP-diacylglycerol synthase Cluster-8309.4315 BF_2 2.00 0.80 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43150 BF_2 585.92 2.47 10205 91083997 XP_975257.1 1901 2.4e-209 PREDICTED: phosphatidate cytidylyltransferase, photoreceptor-specific [Tribolium castaneum]>gi|270007993|gb|EFA04441.1| hypothetical protein TcasGA2_TC014743 [Tribolium castaneum] 729297249 XM_010548190.1 40 2.7058e-08 PREDICTED: Tarenaya hassleriana phosphatidate cytidylyltransferase (LOC104818548), transcript variant X5, mRNA K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 1615 1.5e-177 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 PF05485//PF12906 THAP domain//RING-variant domain GO:0046486//GO:0008654//GO:0016024 glycerolipid metabolic process//phospholipid biosynthetic process//CDP-diacylglycerol biosynthetic process GO:0008270//GO:0004605//GO:0003676 zinc ion binding//phosphatidate cytidylyltransferase activity//nucleic acid binding GO:0016021 integral component of membrane KOG1440 CDP-diacylglycerol synthase Cluster-8309.43153 BF_2 478.08 6.79 3231 642915218 XP_008190526.1 2071 1.5e-229 PREDICTED: UDP-glucose 6-dehydrogenase isoform X1 [Tribolium castaneum] 332376888 BT128627.1 168 5.9547e-80 Dendroctonus ponderosae clone DPO012_D10 unknown mRNA K00012 UGDH, ugd UDPglucose 6-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00012 O02373 1908 4.9e-212 UDP-glucose 6-dehydrogenase OS=Drosophila melanogaster GN=sgl PE=1 SV=1 PF00984//PF02892//PF03446//PF03721//PF03720 UDP-glucose/GDP-mannose dehydrogenase family, central domain//BED zinc finger//NAD binding domain of 6-phosphogluconate dehydrogenase//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain GO:0055114//GO:0006098//GO:0019521 oxidation-reduction process//pentose-phosphate shunt//D-gluconate metabolic process GO:0051287//GO:0016616//GO:0004616//GO:0003677 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//phosphogluconate dehydrogenase (decarboxylating) activity//DNA binding -- -- KOG2666 UDP-glucose/GDP-mannose dehydrogenase Cluster-8309.43155 BF_2 547.42 16.13 1707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04449//PF03153 CS1 type fimbrial major subunit//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672//GO:0009289 transcription factor TFIIA complex//pilus -- -- Cluster-8309.43156 BF_2 182.45 2.77 3047 646682520 KDR02319.1 1568 3.0e-171 Calcium/calmodulin-dependent protein kinase kinase 2 [Zootermopsis nevadensis] 821133341 XM_012518376.1 100 3.54888e-42 PREDICTED: Dasypus novemcinctus calcium/calmodulin-dependent protein kinase kinase 2, beta (CAMKK2), transcript variant X7, mRNA K07359 CAMKK calcium/calmodulin-dependent protein kinase kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07359 Q8C078 1119 1.4e-120 Calcium/calmodulin-dependent protein kinase kinase 2 OS=Mus musculus GN=Camkk2 PE=1 SV=2 PF07714//PF00937//PF00069 Protein tyrosine kinase//Coronavirus nucleocapsid protein//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0019013 viral nucleocapsid KOG0585 Ca2+/calmodulin-dependent protein kinase kinase beta and related serine/threonine protein kinases Cluster-8309.43157 BF_2 327.57 1.42 9930 642912274 XP_008200633.1 4458 0.0e+00 PREDICTED: exportin-7 isoform X1 [Tribolium castaneum] 749773613 XM_011143880.1 434 0 PREDICTED: Harpegnathos saltator exportin-7 (LOC105184822), transcript variant X8, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 3463 0.0e+00 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF13414//PF03810 TPR repeat//Importin-beta N-terminal domain GO:0006886 intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding -- -- KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.43159 BF_2 269.69 2.60 4618 642912496 XP_008200890.1 1792 4.8e-197 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LUQ4 218 6.5e-16 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.4316 BF_2 2.00 0.50 453 194386818 BAG59775.1 696 5.8e-71 unnamed protein product [Homo sapiens] 514052669 NM_001278556.1 425 0 Homo sapiens actin related protein 2/3 complex, subunit 3, 21kDa (ARPC3), transcript variant 1, mRNA K05756 ARPC3 actin related protein 2/3 complex, subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05756 Q3T035 696 2.4e-72 Actin-related protein 2/3 complex subunit 3 OS=Bos taurus GN=ARPC3 PE=1 SV=3 PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005856//GO:0005885 cytoskeleton//Arp2/3 protein complex KOG3155 Actin-related protein Arp2/3 complex, subunit ARPC3 Cluster-8309.43162 BF_2 2.57 0.57 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43163 BF_2 28.00 0.85 1664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01436//PF02723 NHL repeat//Non-structural protein NS3/Small envelope protein E -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.43164 BF_2 17.25 0.67 1370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43166 BF_2 178.58 1.34 5869 270014789 EFA11237.1 2314 1.8e-257 hypothetical protein TcasGA2_TC010769 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHH9 1291 3.1e-140 Tetratricopeptide repeat protein 39B OS=Xenopus laevis GN=ttc39b PE=2 SV=1 PF09110//PF04226//PF00515//PF13181//PF13414//PF13174//PF06703 HAND//Transglycosylase associated protein//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0006465//GO:0043044 signal peptide processing//ATP-dependent chromatin remodeling GO:0008233//GO:0005515//GO:0031491 peptidase activity//protein binding//nucleosome binding GO:0005787//GO:0016021//GO:0000785 signal peptidase complex//integral component of membrane//chromatin KOG1092 Ypt/Rab-specific GTPase-activating protein GYP1 Cluster-8309.43168 BF_2 223.40 1.64 5972 478251857 ENN72296.1 1149 2.3e-122 hypothetical protein YQE_11039, partial [Dendroctonus ponderosae]>gi|546673558|gb|ERL85133.1| hypothetical protein D910_02555 [Dendroctonus ponderosae] -- -- -- -- -- K01834 PGAM, gpmA 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase http://www.genome.jp/dbget-bin/www_bget?ko:K01834 Q5ZLN1 818 2.2e-85 Phosphoglycerate mutase 1 OS=Gallus gallus GN=PGAM1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0235 Phosphoglycerate mutase Cluster-8309.4317 BF_2 1.00 0.55 360 119596081 EAW75675.1 343 3.9e-30 hCG1786148 [Homo sapiens] 514052669 NM_001278556.1 357 0 Homo sapiens actin related protein 2/3 complex, subunit 3, 21kDa (ARPC3), transcript variant 1, mRNA K05756 ARPC3 actin related protein 2/3 complex, subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05756 Q3T035 289 2.9e-25 Actin-related protein 2/3 complex subunit 3 OS=Bos taurus GN=ARPC3 PE=1 SV=3 PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit GO:0034314//GO:0030833 Arp2/3 complex-mediated actin nucleation//regulation of actin filament polymerization -- -- GO:0005856//GO:0005885 cytoskeleton//Arp2/3 protein complex KOG3155 Actin-related protein Arp2/3 complex, subunit ARPC3 Cluster-8309.43170 BF_2 231.77 5.78 1964 546676100 ERL87167.1 1897 1.4e-209 hypothetical protein D910_04567 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H267 422 6.1e-40 Vacuolar protein sorting-associated protein 33B OS=Homo sapiens GN=VPS33B PE=1 SV=2 PF08926//PF00995 Domain of unknown function (DUF1908)//Sec1 family GO:0016192//GO:0016310//GO:0006904//GO:0009069//GO:0006468 vesicle-mediated transport//phosphorylation//vesicle docking involved in exocytosis//serine family amino acid metabolic process//protein phosphorylation GO:0000287//GO:0004674//GO:0005524 magnesium ion binding//protein serine/threonine kinase activity//ATP binding -- -- KOG1302 Vacuolar sorting protein VPS33/slp1 (Sec1 family) Cluster-8309.43174 BF_2 66.19 0.40 7284 332376224 AEE63252.1 1345 5.2e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.1e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF00930//PF01612//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease//WD domain, G-beta repeat GO:0006508//GO:0006139 proteolysis//nucleobase-containing compound metabolic process GO:0008408//GO:0003676//GO:0005515 3'-5' exonuclease activity//nucleic acid binding//protein binding -- -- KOG2248 3'-5' exonuclease Cluster-8309.43176 BF_2 698.60 4.10 7409 332376224 AEE63252.1 1345 5.3e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13917 RNGTT mRNA-capping enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K13917 Q9Y4P3 750 2.1e-77 Transducin beta-like protein 2 OS=Homo sapiens GN=TBL2 PE=1 SV=1 PF00400//PF00930//PF01612 WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease GO:0006139//GO:0006508 nucleobase-containing compound metabolic process//proteolysis GO:0005515//GO:0003676//GO:0008408 protein binding//nucleic acid binding//3'-5' exonuclease activity -- -- KOG2248 3'-5' exonuclease Cluster-8309.43179 BF_2 363.49 3.39 4769 642913355 XP_008195386.1 1300 5.6e-140 PREDICTED: protein polybromo-1 [Tribolium castaneum] -- -- -- -- -- K10738 MCM9 DNA helicase MCM9 http://www.genome.jp/dbget-bin/www_bget?ko:K10738 I0IUP4 1075 2.8e-115 DNA helicase MCM9 OS=Gallus gallus GN=MCM9 PE=1 SV=2 PF08073//PF10660//PF00493//PF07728//PF07726 CHDNT (NUC034) domain//Iron-containing outer mitochondrial membrane protein N-terminus//MCM2/3/5 family//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006355//GO:0006260 regulation of transcription, DNA-templated//DNA replication GO:0008270//GO:0016887//GO:0016818//GO:0005524//GO:0051537//GO:0003677 zinc ion binding//ATPase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//2 iron, 2 sulfur cluster binding//DNA binding GO:0043231//GO:0005634 intracellular membrane-bounded organelle//nucleus KOG0478 DNA replication licensing factor, MCM4 component Cluster-8309.43180 BF_2 328.05 7.63 2086 91080451 XP_969541.1 2760 1.2e-309 PREDICTED: mediator of RNA polymerase II transcription subunit 17 isoform X1 [Tribolium castaneum]>gi|270005569|gb|EFA02017.1| hypothetical protein TcasGA2_TC007640 [Tribolium castaneum] -- -- -- -- -- K15133 MED17 mediator of RNA polymerase II transcription subunit 17 http://www.genome.jp/dbget-bin/www_bget?ko:K15133 Q7PVZ2 2062 4.4e-230 Mediator of RNA polymerase II transcription subunit 17 OS=Anopheles gambiae GN=MED17 PE=3 SV=2 PF04810//PF10156 Sec23/Sec24 zinc finger//Subunit 17 of Mediator complex GO:0006888//GO:0006886//GO:0006357 ER to Golgi vesicle-mediated transport//intracellular protein transport//regulation of transcription from RNA polymerase II promoter GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.43181 BF_2 157.95 3.57 2140 91080451 XP_969541.1 2731 2.9e-306 PREDICTED: mediator of RNA polymerase II transcription subunit 17 isoform X1 [Tribolium castaneum]>gi|270005569|gb|EFA02017.1| hypothetical protein TcasGA2_TC007640 [Tribolium castaneum] -- -- -- -- -- K15133 MED17 mediator of RNA polymerase II transcription subunit 17 http://www.genome.jp/dbget-bin/www_bget?ko:K15133 Q7PVZ2 2034 8.0e-227 Mediator of RNA polymerase II transcription subunit 17 OS=Anopheles gambiae GN=MED17 PE=3 SV=2 PF04810//PF10156 Sec23/Sec24 zinc finger//Subunit 17 of Mediator complex GO:0006357//GO:0006886//GO:0006888 regulation of transcription from RNA polymerase II promoter//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0001104//GO:0008270 RNA polymerase II transcription cofactor activity//zinc ion binding GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.43187 BF_2 443.58 16.69 1399 642922190 XP_008193053.1 1123 5.5e-120 PREDICTED: patronin isoform X1 [Tribolium castaneum] 642922199 XM_008194837.1 290 3.85402e-148 PREDICTED: Tribolium castaneum patronin (LOC660656), transcript variant X6, mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 656 3.2e-67 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex KOG3654 Uncharacterized CH domain protein Cluster-8309.43188 BF_2 572.57 7.67 3409 642922204 XP_008193061.1 936 6.5e-98 PREDICTED: patronin isoform X8 [Tribolium castaneum] 642922199 XM_008194837.1 79 1.876e-30 PREDICTED: Tribolium castaneum patronin (LOC660656), transcript variant X6, mRNA K17493 CAMSAP calmodulin-regulated spectrin-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17493 A1ZAU8 656 7.8e-67 Patronin OS=Drosophila melanogaster GN=Patronin PE=1 SV=1 PF08683 Microtubule-binding calmodulin-regulated spectrin-associated -- -- GO:0008017 microtubule binding GO:0045298 tubulin complex KOG3654 Uncharacterized CH domain protein Cluster-8309.43196 BF_2 4.00 1.89 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43202 BF_2 499.00 4.20 5259 642927507 XP_008195297.1 7776 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule-like protein Dscam2 [Tribolium castaneum] 642927506 XM_008197075.1 1528 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule-like protein Dscam2 (LOC661648), mRNA K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 3232 0.0e+00 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05955//PF05790//PF00041//PF13895//PF16656 Equine herpesvirus glycoprotein gp2//Immunoglobulin C2-set domain//Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0007155//GO:0019497//GO:0016032 riboflavin metabolic process//cell adhesion//hexachlorocyclohexane metabolic process//viral process GO:0046872//GO:0003993//GO:0005515 metal ion binding//acid phosphatase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.43204 BF_2 253.78 2.95 3891 642935329 XP_008197970.1 373 1.4e-32 PREDICTED: regulator of G-protein signaling 7 isoform X1 [Tribolium castaneum] 642935330 XM_008199749.1 107 5.83615e-46 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC656292), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00424 REV protein (anti-repression trans-activator protein) GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0042025 transcription factor complex//host cell nucleus -- -- Cluster-8309.43205 BF_2 1973.00 20.36 4341 91092762 XP_973584.1 4786 0.0e+00 PREDICTED: isoleucine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270014792|gb|EFA11240.1| hypothetical protein TcasGA2_TC010772 [Tribolium castaneum] -- -- -- -- -- K01870 IARS, ileS isoleucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01870 Q8BU30 3651 0.0e+00 Isoleucine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Iars PE=2 SV=2 PF00133//PF09334//PF04083//PF08264 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Partial alpha/beta-hydrolase lipase region//Anticodon-binding domain of tRNA GO:0006450//GO:0009099//GO:0006418//GO:0006629//GO:0006428//GO:0009098//GO:0009097 regulation of translational fidelity//valine biosynthetic process//tRNA aminoacylation for protein translation//lipid metabolic process//isoleucyl-tRNA aminoacylation//leucine biosynthetic process//isoleucine biosynthetic process GO:0004822//GO:0004812//GO:0002161//GO:0000166//GO:0005524 isoleucine-tRNA ligase activity//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG0434 Isoleucyl-tRNA synthetase Cluster-8309.43206 BF_2 71.61 3.68 1102 91082797 XP_967743.1 398 5.1e-36 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 264 7.2e-22 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.43208 BF_2 828.72 7.06 5200 91093137 XP_969665.1 2367 1.1e-263 PREDICTED: breast cancer anti-estrogen resistance protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16832 NEDD9, HEF1, CASL enhancer of filamentation 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16832 Q61140 506 2.9e-49 Breast cancer anti-estrogen resistance protein 1 OS=Mus musculus GN=Bcar1 PE=1 SV=2 PF09726//PF14604//PF00018//PF01282 Transmembrane protein//Variant SH3 domain//SH3 domain//Ribosomal protein S24e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0016021//GO:0005840 intracellular//integral component of membrane//ribosome -- -- Cluster-8309.43209 BF_2 6.00 7.74 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43210 BF_2 413.03 4.72 3950 642928027 XP_008200126.1 3078 0.0e+00 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X3 [Tribolium castaneum] 749778487 XM_011145638.1 73 4.71215e-27 PREDICTED: Harpegnathos saltator epidermal growth factor receptor substrate 15-like 1 (LOC105185837), transcript variant X4, mRNA K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q60902 1260 8.3e-137 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3 PF04111//PF00435//PF13833//PF13405//PF13499//PF12763//PF01920//PF10174//PF10186//PF00036//PF03836//PF02601//PF13202//PF00769 Autophagy protein Apg6//Spectrin repeat//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//Prefoldin subunit//RIM-binding protein of the cytomatrix active zone//Vacuolar sorting 38 and autophagy-related subunit 14//EF hand//RasGAP C-terminus//Exonuclease VII, large subunit//EF hand//Ezrin/radixin/moesin family GO:0006308//GO:0007264//GO:0006457//GO:0010508//GO:0006914 DNA catabolic process//small GTPase mediated signal transduction//protein folding//positive regulation of autophagy//autophagy GO:0005509//GO:0008092//GO:0005515//GO:0008855//GO:0051082//GO:0005096 calcium ion binding//cytoskeletal protein binding//protein binding//exodeoxyribonuclease VII activity//unfolded protein binding//GTPase activator activity GO:0048786//GO:0009318//GO:0016272//GO:0005737//GO:0019898 presynaptic active zone//exodeoxyribonuclease VII complex//prefoldin complex//cytoplasm//extrinsic component of membrane KOG0998 Synaptic vesicle protein EHS-1 and related EH domain proteins Cluster-8309.43214 BF_2 157.76 1.94 3694 642932194 XP_008196896.1 1658 1.3e-181 PREDICTED: transcription factor hamlet-like [Tribolium castaneum] 667674288 AE014134.6 89 5.61683e-36 Drosophila melanogaster chromosome 2L K04462 EVI1 ecotropic virus integration site 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04462 Q8I7Z8 890 6.2e-94 Transcription factor hamlet OS=Drosophila melanogaster GN=ham PE=2 SV=1 PF16622//PF13912//PF02892//PF13465//PF00096 zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.43218 BF_2 116.32 2.35 2355 91088839 XP_970745.1 1131 1.1e-120 PREDICTED: RNA-binding protein lark [Tribolium castaneum]>gi|270012337|gb|EFA08785.1| hypothetical protein TcasGA2_TC006476 [Tribolium castaneum] 642932363 XM_965652.3 358 0 PREDICTED: Tribolium castaneum RNA-binding protein lark (LOC659335), mRNA K13187 RBM4 RNA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13187 Q94901 845 6.5e-89 RNA-binding protein lark OS=Drosophila melanogaster GN=lark PE=1 SV=1 PF00098//PF08777//PF08675//PF00076//PF16367 Zinc knuckle//RNA binding motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0008270//GO:0000166//GO:0004535//GO:0003676//GO:0046872//GO:0003723 zinc ion binding//nucleotide binding//poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus KOG0109 RNA-binding protein LARK, contains RRM and retroviral-type Zn-finger domains Cluster-8309.43223 BF_2 136.68 0.85 7007 642924136 XP_008194022.1 7907 0.0e+00 PREDICTED: neural-cadherin isoform X6 [Tribolium castaneum] 642924135 XM_008195800.1 1710 0 PREDICTED: Tribolium castaneum neural-cadherin (LOC657652), transcript variant X6, mRNA -- -- -- -- O15943 7157 0.0e+00 Neural-cadherin OS=Drosophila melanogaster GN=CadN PE=1 SV=2 PF00672//PF00028//PF01049//PF00008//PF11857 HAMP domain//Cadherin domain//Cadherin cytoplasmic region//EGF-like domain//Domain of unknown function (DUF3377) GO:0007165//GO:0007156 signal transduction//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0004871//GO:0005515//GO:0004222 calcium ion binding//signal transducer activity//protein binding//metalloendopeptidase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.43224 BF_2 31.60 0.52 2837 642930353 XP_008196361.1 542 2.6e-52 PREDICTED: protein 4.1 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K06107 EPB41, 4.1R erythrocyte membrane protein band 4.1 http://www.genome.jp/dbget-bin/www_bget?ko:K06107 Q9V8R9 375 2.5e-34 Protein 4.1 homolog OS=Drosophila melanogaster GN=cora PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3527 Erythrocyte membrane protein 4.1 and related proteins of the ERM family Cluster-8309.43228 BF_2 66.52 0.38 7559 642915588 XP_008190677.1 7723 0.0e+00 PREDICTED: tyrosine-protein phosphatase Lar isoform X3 [Tribolium castaneum] 821135605 XM_012519131.1 232 3.70836e-115 PREDICTED: Dasypus novemcinctus protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant X15, mRNA K05695 PTPRF, LAR receptor-type tyrosine-protein phosphatase F http://www.genome.jp/dbget-bin/www_bget?ko:K05695 P16621 6822 0.0e+00 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF16794//PF00782//PF00102//PF16656//PF00041//PF09472 Fibronectin-III type domain//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) GO:0006771//GO:0006570//GO:0006470//GO:0046656//GO:0019497//GO:0015948 riboflavin metabolic process//tyrosine metabolic process//protein dephosphorylation//folic acid biosynthetic process//hexachlorocyclohexane metabolic process//methanogenesis GO:0046872//GO:0003993//GO:0008138//GO:0005515//GO:0004725//GO:0030269 metal ion binding//acid phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.43229 BF_2 202.81 10.09 1128 642920003 XP_008192163.1 1125 2.6e-120 PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum]>gi|642920005|ref|XP_008192164.1| PREDICTED: stromal interaction molecule homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K16059 STIM1 stromal interaction molecule 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16059 P83094 775 4.1e-81 Stromal interaction molecule homolog OS=Drosophila melanogaster GN=Stim PE=1 SV=1 PF07647//PF03462//PF00536//PF01576//PF06810//PF02203//PF07851//PF15291//PF05478//PF08702//PF10473//PF07926//PF05384 SAM domain (Sterile alpha motif)//PCRF domain//SAM domain (Sterile alpha motif)//Myosin tail//Phage minor structural protein GP20//Tar ligand binding domain homologue//TMPIT-like protein//Dermcidin, antibiotic peptide//Prominin//Fibrinogen alpha/beta chain family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//Sensor protein DegS GO:0051258//GO:0031640//GO:0007165//GO:0006415//GO:0006606//GO:0006935//GO:0006449//GO:0030168 protein polymerization//killing of cells of other organism//signal transduction//translational termination//protein import into nucleus//chemotaxis//regulation of translational termination//platelet activation GO:0008134//GO:0045502//GO:0005198//GO:0008233//GO:0005102//GO:0016301//GO:0005515//GO:0016149//GO:0004888//GO:0003774//GO:0030674//GO:0042803 transcription factor binding//dynein binding//structural molecule activity//peptidase activity//receptor binding//kinase activity//protein binding//translation release factor activity, codon specific//transmembrane signaling receptor activity//motor activity//protein binding, bridging//protein homodimerization activity GO:0016459//GO:0016021//GO:0005577//GO:0005737//GO:0018444//GO:0005840//GO:0005667//GO:0030286//GO:0016020//GO:0005576 myosin complex//integral component of membrane//fibrinogen complex//cytoplasm//translation release factor complex//ribosome//transcription factor complex//dynein complex//membrane//extracellular region KOG4403 Cell surface glycoprotein STIM, contains SAM domain Cluster-8309.43232 BF_2 4738.85 46.35 4564 642915809 XP_008200087.1 1290 7.7e-139 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 594 1.6e-59 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501//PF01450 AMP-binding enzyme//Acetohydroxy acid isomeroreductase, catalytic domain GO:0009099//GO:0055114//GO:0015940//GO:0009098//GO:0009097//GO:0008152//GO:0009082 valine biosynthetic process//oxidation-reduction process//pantothenate biosynthetic process//leucine biosynthetic process//isoleucine biosynthetic process//metabolic process//branched-chain amino acid biosynthetic process GO:0004455//GO:0003824 ketol-acid reductoisomerase activity//catalytic activity -- -- -- -- Cluster-8309.43235 BF_2 1457.21 11.26 5699 91078042 XP_966587.1 1300 6.7e-140 PREDICTED: lipid storage droplets surface-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 792 2.2e-82 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43238 BF_2 901.59 30.89 1508 91079304 XP_966317.1 1568 1.5e-171 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 647 3.8e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.43239 BF_2 228.78 5.88 1916 642933080 XP_008197251.1 1014 3.3e-107 PREDICTED: ribosome biogenesis regulatory protein homolog [Tribolium castaneum] 795027340 XM_012006858.1 35 3.01444e-06 PREDICTED: Vollenhovia emeryi ribosome biogenesis regulatory protein homolog (LOC105558919), mRNA K14852 RRS1 regulator of ribosome biosynthesis http://www.genome.jp/dbget-bin/www_bget?ko:K14852 Q2KIH4 604 4.7e-61 Ribosome biogenesis regulatory protein homolog OS=Bos taurus GN=RRS1 PE=2 SV=1 PF04939 Ribosome biogenesis regulatory protein (RRS1) GO:0042254 ribosome biogenesis -- -- GO:0005634 nucleus KOG1765 Regulator of ribosome synthesis Cluster-8309.43240 BF_2 904.01 16.24 2616 642935586 XP_008198071.1 3030 0.0e+00 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase, isoform M isoform X9 [Tribolium castaneum] 642935585 XM_008199849.1 1006 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I (LOC662977), transcript variant X11, mRNA K13293 PDE4 cAMP-specific phosphodiesterase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13293 Q9W4T4 2356 4.5e-264 cAMP-specific 3',5'-cyclic phosphodiesterase, isoform I OS=Drosophila melanogaster GN=dnc PE=1 SV=2 PF00233//PF07469 3'5'-cyclic nucleotide phosphodiesterase//Domain of unknown function (DUF1518) GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0005634 nucleus KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.43241 BF_2 108.05 0.52 8930 478251476 ENN71939.1 1947 9.9e-215 hypothetical protein YQE_11373, partial [Dendroctonus ponderosae] 642917170 XM_966698.2 42 1.82943e-09 PREDICTED: Tribolium castaneum centrosomin (LOC660470), transcript variant X2, mRNA K16718 CNN centrosomin http://www.genome.jp/dbget-bin/www_bget?ko:K16718 Q54G05 303 1.8e-25 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF07926//PF07989//PF04406//PF01608//PF03938//PF00831//PF02183 TPR/MLP1/MLP2-like protein//Centrosomin N-terminal motif 1//Type IIB DNA topoisomerase//I/LWEQ domain//Outer membrane protein (OmpH-like)//Ribosomal L29 protein//Homeobox associated leucine zipper GO:0042254//GO:0006606//GO:0006355//GO:0006412//GO:0006259 ribosome biogenesis//protein import into nucleus//regulation of transcription, DNA-templated//translation//DNA metabolic process GO:0003779//GO:0005524//GO:0003700//GO:0043565//GO:0051082//GO:0003735//GO:0003677//GO:0003824 actin binding//ATP binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//unfolded protein binding//structural constituent of ribosome//DNA binding//catalytic activity GO:0005815//GO:0005622//GO:0005840//GO:0005667//GO:0005694 microtubule organizing center//intracellular//ribosome//transcription factor complex//chromosome -- -- Cluster-8309.43242 BF_2 19.42 0.53 1807 549438539 AGX25158.1 548 3.4e-53 windbeutel-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K09586 ERP29 endoplasmic reticulum protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K09586 O44342 253 2.2e-20 Protein windbeutel OS=Drosophila melanogaster GN=wbl PE=1 SV=1 PF07912//PF07749 ERp29, N-terminal domain//Endoplasmic reticulum protein ERp29, C-terminal domain GO:0009306 protein secretion -- -- GO:0005783//GO:0005788 endoplasmic reticulum//endoplasmic reticulum lumen -- -- Cluster-8309.43243 BF_2 53.00 108.97 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.43244 BF_2 604.68 15.77 1891 642917401 XP_008191181.1 1711 4.9e-188 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Tribolium castaneum] 167777849 CP000786.1 38 6.39301e-08 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome I, complete sequence -- -- -- -- A1L258 1469 2.3e-161 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF01565//PF02913 FAD binding domain//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0050660//GO:0003824//GO:0016491 flavin adenine dinucleotide binding//catalytic activity//oxidoreductase activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.43246 BF_2 127.66 1.97 2997 642923800 XP_008193888.1 1414 2.1e-153 PREDICTED: uncharacterized protein LOC663689 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04999 Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.43248 BF_2 181.39 1.78 4557 546684844 ERL94426.1 2530 1.3e-282 hypothetical protein D910_11704 [Dendroctonus ponderosae] -- -- -- -- -- K01769 E4.6.1.2 guanylate cyclase, other http://www.genome.jp/dbget-bin/www_bget?ko:K01769 Q9VEU5 1448 1.5e-158 Soluble guanylate cyclase 89Db OS=Drosophila melanogaster GN=Gyc-89Db PE=1 SV=1 PF00211//PF08144//PF07700//PF02285//PF07701 Adenylate and Guanylate cyclase catalytic domain//CPL (NUC119) domain//Haem-NO-binding//Cytochrome oxidase c subunit VIII//Heme NO binding associated GO:0006144//GO:0006123//GO:0046039//GO:0006182//GO:0015992//GO:0009190//GO:0035556 purine nucleobase metabolic process//mitochondrial electron transport, cytochrome c to oxygen//GTP metabolic process//cGMP biosynthetic process//proton transport//cyclic nucleotide biosynthetic process//intracellular signal transduction GO:0003723//GO:0004129//GO:0020037//GO:0016849//GO:0004383 RNA binding//cytochrome-c oxidase activity//heme binding//phosphorus-oxygen lyase activity//guanylate cyclase activity GO:0045277 respiratory chain complex IV KOG4171 Adenylate/guanylate kinase Cluster-8309.43249 BF_2 25.33 0.51 2347 270004866 EFA01314.1 267 1.7e-20 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P4P2 235 3.5e-18 Fibrinogen C domain-containing protein 1 OS=Xenopus tropicalis GN=fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43254 BF_2 32.81 0.87 1861 642923726 XP_008193858.1 270 5.9e-21 PREDICTED: long-chain-fatty-acid--CoA ligase 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01897 ACSL, fadD long-chain acyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43256 BF_2 740.00 9.74 3465 478262485 ENN81156.1 3139 0.0e+00 hypothetical protein YQE_02522, partial [Dendroctonus ponderosae] 642911150 XM_008202380.1 416 0 PREDICTED: Tribolium castaneum rho GTPase-activating protein 39 (LOC660972), mRNA -- -- -- -- Q9C0H5 959 5.8e-102 Rho GTPase-activating protein 39 OS=Homo sapiens GN=ARHGAP39 PE=1 SV=2 PF00784//PF00620//PF00397 MyTH4 domain//RhoGAP domain//WW domain GO:0007165 signal transduction GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.43257 BF_2 1220.14 4.92 10665 642911349 XP_008199384.1 4239 0.0e+00 PREDICTED: uncharacterized protein LOC659886 isoform X1 [Tribolium castaneum] 642911358 XM_008201167.1 137 3.38462e-62 PREDICTED: Tribolium castaneum uncharacterized LOC659886 (LOC659886), transcript variant X6, mRNA -- -- -- -- B6RSP1 355 2.0e-31 Pleckstrin homology domain-containing family A member 7 OS=Danio rerio GN=plekha7 PE=2 SV=2 PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.43259 BF_2 1237.37 17.81 3193 546677672 ERL88466.1 763 7.0e-78 hypothetical protein D910_05852, partial [Dendroctonus ponderosae] 462342680 APGK01035633.1 36 1.40624e-06 Dendroctonus ponderosae Seq01035643, whole genome shotgun sequence -- -- -- -- Q7SXT7 291 1.5e-24 Zinc finger C2HC domain-containing protein 1A OS=Danio rerio GN=zc2hc1a PE=2 SV=1 PF02964//PF01155//PF00096//PF04690//PF15168 Methane monooxygenase, hydrolase gamma chain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//YABBY protein//Triple QxxK/R motif-containing protein family GO:0007275//GO:0006464//GO:0015947//GO:0006118 multicellular organismal development//cellular protein modification process//methane metabolic process//obsolete electron transport GO:0016151//GO:0046872//GO:0015049 nickel cation binding//metal ion binding//methane monooxygenase activity GO:0005789//GO:0015050 endoplasmic reticulum membrane//methane monooxygenase complex KOG3940 Uncharacterized conserved protein Cluster-8309.43260 BF_2 359.22 8.83 1988 91077554 XP_972108.1 1153 2.6e-123 PREDICTED: 39S ribosomal protein L2, mitochondrial [Tribolium castaneum]>gi|270001586|gb|EEZ98033.1| hypothetical protein TcasGA2_TC000434 [Tribolium castaneum] -- -- -- -- -- K02886 RP-L2, MRPL2, rplB large subunit ribosomal protein L2 http://www.genome.jp/dbget-bin/www_bget?ko:K02886 Q498T4 482 6.8e-47 39S ribosomal protein L2, mitochondrial OS=Rattus norvegicus GN=Mrpl2 PE=2 SV=1 PF00181//PF03947 Ribosomal Proteins L2, RNA binding domain//Ribosomal Proteins L2, C-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0438 Mitochondrial/chloroplast ribosomal protein L2 Cluster-8309.43261 BF_2 23.14 0.35 3074 642931611 XP_971230.2 3097 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Tribolium castaneum] 808137240 XR_001099267.1 138 2.69082e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 2.9e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.43262 BF_2 277.03 3.89 3269 642931611 XP_971230.2 2719 1.1e-304 PREDICTED: sphingomyelin phosphodiesterase isoform X1 [Tribolium castaneum] 808137240 XR_001099267.1 138 2.86354e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 3.1e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.43263 BF_2 321.16 7.95 1977 642931613 XP_008196656.1 3053 0.0e+00 PREDICTED: sphingomyelin phosphodiesterase isoform X2 [Tribolium castaneum] 808137240 XR_001099267.1 138 1.72061e-63 PREDICTED: Bombus terrestris sphingomyelin phosphodiesterase (LOC100651097), transcript variant X8, misc_RNA K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 P17405 1194 1.9e-129 Sphingomyelin phosphodiesterase OS=Homo sapiens GN=SMPD1 PE=1 SV=4 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.43264 BF_2 118.81 0.77 6768 642920095 XP_008192202.1 1751 4.0e-192 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 7.49454e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.1e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43265 BF_2 1347.00 17.07 3589 642924886 XP_008194084.1 2016 4.0e-223 PREDICTED: serine/threonine-protein kinase MST4 isoform X2 [Tribolium castaneum] 642924885 XM_008195862.1 465 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase MST4 (LOC103313200), transcript variant X3, mRNA K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 Q99KH8 1092 2.3e-117 Serine/threonine-protein kinase 24 OS=Mus musculus GN=Stk24 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0201 Serine/threonine protein kinase Cluster-8309.43267 BF_2 846.79 4.20 8726 270001102 EEZ97549.1 1832 2.1e-201 hypothetical protein TcasGA2_TC011399 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZW4 179 4.1e-11 Dentin sialophosphoprotein OS=Homo sapiens GN=DSPP PE=1 SV=2 PF04433//PF03931 SWIRM domain//Skp1 family, tetramerisation domain GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- -- -- Cluster-8309.43271 BF_2 1066.55 22.87 2238 642921254 XP_008192785.1 1716 1.5e-188 PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|642921256|ref|XP_008192787.1| PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|270006236|gb|EFA02684.1| hypothetical protein TcasGA2_TC008405 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q9VL78 1056 2.1e-113 FK506-binding protein 59 OS=Drosophila melanogaster GN=FKBP59 PE=1 SV=1 PF13174//PF13181//PF13414//PF00254//PF13176//PF04434//PF13371//PF00515 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//SWIM zinc finger//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.43274 BF_2 15.41 0.31 2346 -- -- -- -- -- 642919184 XM_962644.3 56 7.84842e-18 PREDICTED: Tribolium castaneum transcription factor AP-4 (LOC656093), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43275 BF_2 571.87 4.34 5799 820805554 AKG92768.1 605 2.6e-59 cropped [Leptinotarsa decemlineata] -- -- -- -- -- K09108 TFAP4 transcription factor AP-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09108 Q01664 164 1.5e-09 Transcription factor AP-4 OS=Homo sapiens GN=TFAP4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43280 BF_2 226.00 5.30 2072 -- -- -- -- -- 642917898 XM_008193153.1 95 1.44542e-39 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43281 BF_2 29.73 0.52 2677 642917897 XP_008191374.1 2213 4.2e-246 PREDICTED: nuclear hormone receptor FTZ-F1 isoform X2 [Tribolium castaneum] 642917896 XM_008193152.1 723 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1606 4.2e-177 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00105//PF00104//PF00288 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//GHMP kinases N terminal domain GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0003700//GO:0043565//GO:0008270 ATP binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.43282 BF_2 102.41 0.94 4868 478254660 ENN74901.1 1209 2.0e-129 hypothetical protein YQE_08479, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12109 CXCR4 Chemokine receptor N terminal -- -- GO:0019955 cytokine binding -- -- -- -- Cluster-8309.43283 BF_2 113.05 5.56 1138 332373134 AEE61708.1 1176 3.2e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00913 ITPK1 inositol-1,3,4-trisphosphate 5/6-kinase / inositol-tetrakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00913 Q7ZU91 615 1.5e-62 Inositol-tetrakisphosphate 1-kinase OS=Danio rerio GN=itpk1 PE=2 SV=2 PF02655//PF05770 ATP-grasp domain//Inositol 1, 3, 4-trisphosphate 5/6-kinase GO:0032957 inositol trisphosphate metabolic process GO:0052725//GO:0046872//GO:0000287//GO:0052726//GO:0005524//GO:0047325 inositol-1,3,4-trisphosphate 6-kinase activity//metal ion binding//magnesium ion binding//inositol-1,3,4-trisphosphate 5-kinase activity//ATP binding//inositol tetrakisphosphate 1-kinase activity GO:0005622 intracellular -- -- Cluster-8309.43286 BF_2 132.42 1.26 4699 642924662 XP_008194386.1 2585 5.5e-289 PREDICTED: tensin isoform X12 [Tribolium castaneum] -- -- -- -- -- K18080 TNS tensin http://www.genome.jp/dbget-bin/www_bget?ko:K18080 Q9HBL0 649 7.0e-66 Tensin-1 OS=Homo sapiens GN=TNS1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43287 BF_2 1223.20 25.28 2311 91087799 XP_967345.1 3105 0.0e+00 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X2 [Tribolium castaneum] 572269851 XM_006612875.1 387 0 PREDICTED: Apis dorsata threonine--tRNA ligase, cytoplasmic-like (LOC102672191), transcript variant X2, mRNA K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q9D0R2 2689 9.6e-303 Threonine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Tars PE=1 SV=2 PF00587//PF07973 tRNA synthetase class II core domain (G, H, P, S and T)//Threonyl and Alanyl tRNA synthetase second additional domain GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0005524//GO:0000166//GO:0016876//GO:0004812 ATP binding//nucleotide binding//ligase activity, forming aminoacyl-tRNA and related compounds//aminoacyl-tRNA ligase activity -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.43289 BF_2 143.69 2.18 3044 642923201 XP_008193653.1 948 2.3e-99 PREDICTED: apoptotic chromatin condensation inducer in the nucleus [Tribolium castaneum]>gi|270007592|gb|EFA04040.1| hypothetical protein TcasGA2_TC014271 [Tribolium castaneum] -- -- -- -- -- K12875 ACIN1, ACINUS apoptotic chromatin condensation inducer in the nucleus http://www.genome.jp/dbget-bin/www_bget?ko:K12875 Q9JIX8 284 9.5e-24 Apoptotic chromatin condensation inducer in the nucleus OS=Mus musculus GN=Acin1 PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG2416 Acinus (induces apoptotic chromatin condensation) Cluster-8309.43291 BF_2 761.99 5.57 6007 642911463 XP_008199434.1 1028 2.4e-108 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF15220//PF03323 MAP7 (E-MAP-115) family//Hypoxia-inducible lipid droplet-associated//Bacillus/Clostridium GerA spore germination protein GO:0000226//GO:0010884//GO:0001819//GO:0009847//GO:0008284 microtubule cytoskeleton organization//positive regulation of lipid storage//positive regulation of cytokine production//spore germination//positive regulation of cell proliferation -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.43292 BF_2 461.25 3.71 5482 642937541 XP_008199088.1 4421 0.0e+00 PREDICTED: ribonuclease 3 [Tribolium castaneum] 820865686 XM_012493878.1 559 0 PREDICTED: Apis florea ribonuclease 3 (LOC100863432), mRNA K03685 rnc, DROSHA, RNT1 ribonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K03685 Q9NRR4 2767 2.1e-311 Ribonuclease 3 OS=Homo sapiens GN=DROSHA PE=1 SV=2 PF00636//PF14622 Ribonuclease III domain//Ribonuclease-III-like GO:0051252//GO:0006396 regulation of RNA metabolic process//RNA processing GO:0003723//GO:0004525 RNA binding//ribonuclease III activity -- -- KOG1817 Ribonuclease Cluster-8309.43294 BF_2 655.92 8.64 3464 642938815 XP_008199930.1 763 7.5e-78 PREDICTED: uncharacterized protein LOC103314794 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.43295 BF_2 2880.44 49.27 2733 571330972 AHF27418.1 1958 1.6e-216 putative sugar transporter 4_2 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.54308e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 942 4.3e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF08157//PF07690//PF00083 NUC129 domain//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0569 Permease of the major facilitator superfamily Cluster-8309.43296 BF_2 34.53 1.42 1307 668458368 KFB46282.1 1732 1.2e-190 AGAP004610-PA-like protein [Anopheles sinensis] 820863197 XM_012492833.1 398 0 PREDICTED: Apis florea signal recognition particle 54 kDa protein (LOC105736738), partial mRNA K03106 SRP54, ffh signal recognition particle subunit SRP54 http://www.genome.jp/dbget-bin/www_bget?ko:K03106 P14576 1576 6.2e-174 Signal recognition particle 54 kDa protein OS=Mus musculus GN=Srp54 PE=1 SV=2 PF01583//PF01926//PF01591//PF00004//PF02978//PF00448//PF02881//PF06414//PF04851//PF03205//PF10662 Adenylylsulphate kinase//50S ribosome-binding GTPase//6-phosphofructo-2-kinase//ATPase family associated with various cellular activities (AAA)//Signal peptide binding domain//SRP54-type protein, GTPase domain//SRP54-type protein, helical bundle domain//Zeta toxin//Type III restriction enzyme, res subunit//Molybdopterin guanine dinucleotide synthesis protein B//Ethanolamine utilisation - propanediol utilisation GO:0006000//GO:0006777//GO:0006614//GO:0006013//GO:0006144//GO:0000103//GO:0006576 fructose metabolic process//Mo-molybdopterin cofactor biosynthetic process//SRP-dependent cotranslational protein targeting to membrane//mannose metabolic process//purine nucleobase metabolic process//sulfate assimilation//cellular biogenic amine metabolic process GO:0016301//GO:0005524//GO:0016787//GO:0008312//GO:0005525//GO:0003873//GO:0004020//GO:0003677 kinase activity//ATP binding//hydrolase activity//7S RNA binding//GTP binding//6-phosphofructo-2-kinase activity//adenylylsulfate kinase activity//DNA binding GO:0048500 signal recognition particle KOG0780 Signal recognition particle, subunit Srp54 Cluster-8309.43297 BF_2 627.47 24.47 1360 817068229 XP_012256040.1 1888 1.0e-208 PREDICTED: signal recognition particle 54 kDa protein [Athalia rosae] 242009195 XM_002425332.1 477 0 Pediculus humanus corporis Signal recognition particle 54 kDa protein, putative, mRNA K03106 SRP54, ffh signal recognition particle subunit SRP54 http://www.genome.jp/dbget-bin/www_bget?ko:K03106 P14576 1716 3.8e-190 Signal recognition particle 54 kDa protein OS=Mus musculus GN=Srp54 PE=1 SV=2 PF03205//PF04851//PF06414//PF10662//PF01583//PF01926//PF00004//PF02978//PF01591//PF02881//PF00448 Molybdopterin guanine dinucleotide synthesis protein B//Type III restriction enzyme, res subunit//Zeta toxin//Ethanolamine utilisation - propanediol utilisation//Adenylylsulphate kinase//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Signal peptide binding domain//6-phosphofructo-2-kinase//SRP54-type protein, helical bundle domain//SRP54-type protein, GTPase domain GO:0006000//GO:0006777//GO:0006614//GO:0006013//GO:0000103//GO:0006144//GO:0006576 fructose metabolic process//Mo-molybdopterin cofactor biosynthetic process//SRP-dependent cotranslational protein targeting to membrane//mannose metabolic process//sulfate assimilation//purine nucleobase metabolic process//cellular biogenic amine metabolic process GO:0016301//GO:0016787//GO:0005524//GO:0005525//GO:0008312//GO:0004020//GO:0003873//GO:0003677 kinase activity//hydrolase activity//ATP binding//GTP binding//7S RNA binding//adenylylsulfate kinase activity//6-phosphofructo-2-kinase activity//DNA binding GO:0048500 signal recognition particle KOG0780 Signal recognition particle, subunit Srp54 Cluster-8309.43298 BF_2 86.00 0.58 6528 189240987 XP_001809298.1 1830 2.7e-201 PREDICTED: probable sodium/potassium/calcium exchanger CG1090 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q9VN12 1493 1.3e-163 Probable sodium/potassium/calcium exchanger CG1090 OS=Drosophila melanogaster GN=CG1090 PE=2 SV=3 PF04428//PF01699//PF03037 Choline kinase N terminus//Sodium/calcium exchanger protein//Kinetoplastid membrane protein 11 GO:0055085//GO:0008284//GO:0006952 transmembrane transport//positive regulation of cell proliferation//defense response GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.43302 BF_2 728.16 26.17 1451 91081971 XP_967978.1 987 3.3e-104 PREDICTED: plexin domain-containing protein 2 [Tribolium castaneum]>gi|270007319|gb|EFA03767.1| hypothetical protein TcasGA2_TC013878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DC11 523 8.8e-52 Plexin domain-containing protein 2 OS=Mus musculus GN=Plxdc2 PE=1 SV=1 PF01437 Plexin repeat -- -- -- -- GO:0016020 membrane KOG3848 Extracellular protein TEM7, contains PSI domain (tumor endothelial marker in humans) Cluster-8309.43303 BF_2 308.00 8.86 1742 642929509 XP_975022.2 1897 1.2e-209 PREDICTED: protein CLP1 homolog [Tribolium castaneum] -- -- -- -- -- K14399 CLP1, HERB polyribonucleotide 5'-hydroxyl-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K14399 Q7QJW7 1503 2.4e-165 Protein CLP1 homolog OS=Anopheles gambiae GN=cbc PE=3 SV=2 PF06807//PF01926 Pre-mRNA cleavage complex II protein Clp1//50S ribosome-binding GTPase GO:0031124 mRNA 3'-end processing GO:0005525 GTP binding -- -- KOG2749 mRNA cleavage and polyadenylation factor IA/II complex, subunit CLP1 Cluster-8309.43304 BF_2 677.93 17.30 1926 91076494 XP_972946.1 541 2.3e-52 PREDICTED: protein CREG1 [Tribolium castaneum]>gi|270002600|gb|EEZ99047.1| hypothetical protein TcasGA2_TC004921 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ73 394 1.1e-36 Protein CREG1 OS=Gallus gallus GN=CREG1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43306 BF_2 216.06 1.69 5625 642935280 XP_008197946.1 1202 1.5e-128 PREDICTED: adenosine receptor A2a [Tribolium castaneum] -- -- -- -- -- K04266 ADORA2A, ADOR adenosine receptor A2a http://www.genome.jp/dbget-bin/www_bget?ko:K04266 O13076 453 4.5e-43 Adenosine receptor A2b OS=Gallus gallus GN=ADORA2B PE=2 SV=1 PF10716//PF00643//PF00001 NADH dehydrogenase transmembrane subunit//B-box zinc finger//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0006118//GO:0055114 G-protein coupled receptor signaling pathway//obsolete electron transport//oxidation-reduction process GO:0004930//GO:0008270//GO:0016655 G-protein coupled receptor activity//zinc ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.43307 BF_2 204.90 3.62 2654 91081405 XP_972749.1 1686 5.4e-185 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 751 5.9e-78 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF03310//PF12689 Caulimovirus DNA-binding protein//Acid Phosphatase -- -- GO:0003677//GO:0016791 DNA binding//phosphatase activity -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.43309 BF_2 717.34 13.15 2569 91081405 XP_972749.1 1798 5.4e-198 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 754 2.5e-78 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF03310//PF12689 Caulimovirus DNA-binding protein//Acid Phosphatase -- -- GO:0003677//GO:0016791 DNA binding//phosphatase activity -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.43310 BF_2 2876.88 68.39 2047 546675018 ERL86281.1 1576 2.4e-172 hypothetical protein D910_03690 [Dendroctonus ponderosae] -- -- -- -- -- K01758 CTH cystathionine gamma-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01758 Q58DW2 1175 3.1e-127 Cystathionine gamma-lyase OS=Bos taurus GN=CTH PE=2 SV=1 PF00155//PF01212//PF01053 Aminotransferase class I and II//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0006520//GO:0009058 cellular amino acid metabolic process//biosynthetic process GO:0030170//GO:0016829 pyridoxal phosphate binding//lyase activity -- -- KOG0053 Cystathionine beta-lyases/cystathionine gamma-synthases Cluster-8309.43311 BF_2 244.65 1.82 5910 642916978 XP_008199580.1 1043 4.4e-110 PREDICTED: leukocyte receptor cluster member 8 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CBY3 733 1.6e-75 Leukocyte receptor cluster member 8 homolog OS=Mus musculus GN=Leng8 PE=1 SV=1 PF02978//PF01785 Signal peptide binding domain//Closterovirus coat protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0019012//GO:0048500 virion//signal recognition particle KOG1861 Leucine permease transcriptional regulator Cluster-8309.43312 BF_2 179.89 15.09 786 478251617 ENN72078.1 335 7.3e-29 hypothetical protein YQE_11264, partial [Dendroctonus ponderosae]>gi|546674549|gb|ERL85905.1| hypothetical protein D910_03320 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BW72 223 2.9e-17 HIG1 domain family member 2A, mitochondrial OS=Homo sapiens GN=HIGD2A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4431 Uncharacterized protein, induced by hypoxia Cluster-8309.43314 BF_2 39.48 0.75 2481 189239692 XP_967139.2 1102 2.7e-117 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 68 1.77287e-24 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 751 5.5e-78 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2736 Presenilin Cluster-8309.43315 BF_2 985.97 10.52 4207 642915942 XP_008190821.1 3449 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 5-like isoform X3 [Tribolium castaneum] 505775864 XM_004602277.1 54 1.83181e-16 PREDICTED: Sorex araneus ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), partial mRNA K05658 ABCB1 ATP-binding cassette, subfamily B (MDR/TAP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05658 P21448 2396 1.7e-268 Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2 PF00931//PF00503//PF07931//PF06414//PF08303//PF00004//PF00664//PF13304//PF01926//PF07728//PF00910//PF00485//PF00006//PF00005//PF03193//PF01443//PF01583 NB-ARC domain//G-protein alpha subunit//Chloramphenicol phosphotransferase-like protein//Zeta toxin//tRNA ligase kinase domain//ATPase family associated with various cellular activities (AAA)//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//AAA domain (dynein-related subfamily)//RNA helicase//Phosphoribulokinase / Uridine kinase family//ATP synthase alpha/beta family, nucleotide-binding domain//ABC transporter//Protein of unknown function, DUF258//Viral (Superfamily 1) RNA helicase//Adenylylsulphate kinase GO:0008152//GO:0006388//GO:0006144//GO:0000103//GO:0007165//GO:0055085//GO:0006810//GO:0007186 metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//purine nucleobase metabolic process//sulfate assimilation//signal transduction//transmembrane transport//transport//G-protein coupled receptor signaling pathway GO:0003723//GO:0043531//GO:0004020//GO:0005525//GO:0004871//GO:0003724//GO:0005524//GO:0031683//GO:0016740//GO:0003924//GO:0003972//GO:0019001//GO:0016887//GO:0016301//GO:0042626 RNA binding//ADP binding//adenylylsulfate kinase activity//GTP binding//signal transducer activity//RNA helicase activity//ATP binding//G-protein beta/gamma-subunit complex binding//transferase activity//GTPase activity//RNA ligase (ATP) activity//guanyl nucleotide binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0055 Multidrug/pheromone exporter, ABC superfamily Cluster-8309.43316 BF_2 1305.03 14.82 3970 642915938 XP_008190820.1 3589 0.0e+00 PREDICTED: ATP-binding cassette sub-family B member 5-like isoform X1 [Tribolium castaneum]>gi|270004089|gb|EFA00537.1| hypothetical protein TcasGA2_TC003402 [Tribolium castaneum] 505775864 XM_004602277.1 54 1.72772e-16 PREDICTED: Sorex araneus ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), partial mRNA K05658 ABCB1 ATP-binding cassette, subfamily B (MDR/TAP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05658 P21448 2470 4.1e-277 Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2 PF00910//PF00485//PF00006//PF03193//PF00005//PF01443//PF01583//PF00931//PF00503//PF06414//PF07931//PF08303//PF00004//PF13304//PF01926//PF00664//PF07728 RNA helicase//Phosphoribulokinase / Uridine kinase family//ATP synthase alpha/beta family, nucleotide-binding domain//Protein of unknown function, DUF258//ABC transporter//Viral (Superfamily 1) RNA helicase//Adenylylsulphate kinase//NB-ARC domain//G-protein alpha subunit//Zeta toxin//Chloramphenicol phosphotransferase-like protein//tRNA ligase kinase domain//ATPase family associated with various cellular activities (AAA)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region//AAA domain (dynein-related subfamily) GO:0000103//GO:0006144//GO:0008152//GO:0006388//GO:0007186//GO:0006810//GO:0055085//GO:0007165 sulfate assimilation//purine nucleobase metabolic process//metabolic process//tRNA splicing, via endonucleolytic cleavage and ligation//G-protein coupled receptor signaling pathway//transport//transmembrane transport//signal transduction GO:0003724//GO:0017111//GO:0004871//GO:0005525//GO:0004020//GO:0043531//GO:0003723//GO:0042626//GO:0019001//GO:0016887//GO:0016301//GO:0003924//GO:0003972//GO:0016740//GO:0031683//GO:0005524 RNA helicase activity//nucleoside-triphosphatase activity//signal transducer activity//GTP binding//adenylylsulfate kinase activity//ADP binding//RNA binding//ATPase activity, coupled to transmembrane movement of substances//guanyl nucleotide binding//ATPase activity//kinase activity//GTPase activity//RNA ligase (ATP) activity//transferase activity//G-protein beta/gamma-subunit complex binding//ATP binding GO:0016021 integral component of membrane KOG0055 Multidrug/pheromone exporter, ABC superfamily Cluster-8309.43317 BF_2 30.00 0.43 3224 672273128 KFG45225.1 147 1.9e-06 IgA-specific metalloendopeptidase [Toxoplasma gondii GAB2-2007-GAL-DOM2] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03502 Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279 cell outer membrane -- -- Cluster-8309.43318 BF_2 8645.92 65.04 5848 270007317 EFA03765.1 2886 0.0e+00 hypothetical protein TcasGA2_TC013876 [Tribolium castaneum] 642921924 XM_008194725.1 121 1.45168e-53 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 889 1.3e-93 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02020//PF05372//PF02854 eIF4-gamma/eIF5/eIF2-epsilon//Delta lysin family//MIF4G domain GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515//GO:0003723 protein binding//RNA binding GO:0005576 extracellular region KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.43319 BF_2 1504.63 12.81 5200 642921925 XP_008192947.1 2157 2.6e-239 PREDICTED: eukaryotic translation initiation factor 4 gamma 3-like isoform X3 [Tribolium castaneum] 642921924 XM_008194725.1 121 1.28983e-53 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4 gamma 3-like (LOC656935), transcript variant X3, mRNA K03260 EIF4G translation initiation factor 4G http://www.genome.jp/dbget-bin/www_bget?ko:K03260 O43432 889 1.1e-93 Eukaryotic translation initiation factor 4 gamma 3 OS=Homo sapiens GN=EIF4G3 PE=1 SV=2 PF02020//PF02854//PF05372 eIF4-gamma/eIF5/eIF2-epsilon//MIF4G domain//Delta lysin family GO:0019836 hemolysis by symbiont of host erythrocytes GO:0005515//GO:0003723 protein binding//RNA binding GO:0005576 extracellular region KOG0401 Translation initiation factor 4F, ribosome/mRNA-bridging subunit (eIF-4G) Cluster-8309.43320 BF_2 1074.75 19.41 2604 642926864 XP_008195044.1 2348 9.2e-262 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum] 748585115 LC002996.1 39 2.46034e-08 Ostrinia furnacalis gene for hypothetical protein, partial cds, note: entry16 -- -- -- -- O18824 615 3.4e-62 Scavenger receptor class B member 1 OS=Bos taurus GN=SCARB1 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43321 BF_2 101.86 1.22 3785 642932100 XP_008196854.1 1534 3.3e-167 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 585712445 XM_006900338.1 83 1.24608e-32 PREDICTED: Elephantulus edwardii splA/ryanodine receptor domain and SOCS box containing 4 (SPSB4), mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 4.8e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF00622//PF07525//PF01213 SPRY domain//SOCS box//Adenylate cyclase associated (CAP) N terminal GO:0007010//GO:0035556 cytoskeleton organization//intracellular signal transduction GO:0005515//GO:0003779 protein binding//actin binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.43323 BF_2 6.00 43.38 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43325 BF_2 5.24 0.35 909 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43326 BF_2 531.82 2.82 8188 642929719 XP_008195949.1 2566 1.5e-286 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform isoform X3 [Tribolium castaneum] 195497533 XM_002096105.1 295 3.82431e-150 Drosophila yakuba GE25516 (Dyak\GE25516), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q14738 2003 1.2e-222 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens GN=PPP2R5D PE=1 SV=1 PF01695//PF07728//PF05496//PF01603//PF06068//PF00004//PF07724 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Protein phosphatase 2A regulatory B subunit (B56 family)//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily) GO:0006310//GO:0006281//GO:0007165 DNA recombination//DNA repair//signal transduction GO:0009378//GO:0016887//GO:0008601//GO:0005524//GO:0003678 four-way junction helicase activity//ATPase activity//protein phosphatase type 2A regulator activity//ATP binding//DNA helicase activity GO:0000159//GO:0009379//GO:0005657 protein phosphatase type 2A complex//Holliday junction helicase complex//replication fork KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.43329 BF_2 13.01 0.60 1195 91077558 XP_972317.1 249 1.0e-18 PREDICTED: sorbitol dehydrogenase [Tribolium castaneum]>gi|270002167|gb|EEZ98614.1| hypothetical protein TcasGA2_TC001136 [Tribolium castaneum] -- -- -- -- -- K00008 SORD, gutB L-iditol 2-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00008 -- -- -- -- PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0000166//GO:0008270//GO:0046872//GO:0016491 nucleotide binding//zinc ion binding//metal ion binding//oxidoreductase activity -- -- KOG0024 Sorbitol dehydrogenase Cluster-8309.43330 BF_2 304.65 2.55 5293 189234120 XP_968578.2 724 3.8e-73 PREDICTED: tetraspanin-13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17356 TSPAN13_31 tetraspanin-13/31 http://www.genome.jp/dbget-bin/www_bget?ko:K17356 Q5XHG6 407 9.0e-38 Tetraspanin-31-A OS=Xenopus laevis GN=tspan31-a PE=2 SV=1 PF00076//PF07574//PF00335//PF11837 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nse1 non-SMC component of SMC5-6 complex//Tetraspanin family//Domain of unknown function (DUF3357) GO:0006012//GO:0005985//GO:0005982//GO:0006281 galactose metabolic process//sucrose metabolic process//starch metabolic process//DNA repair GO:0004575//GO:0003676//GO:0004564 sucrose alpha-glucosidase activity//nucleic acid binding//beta-fructofuranosidase activity GO:0030915//GO:0016021//GO:0017177 Smc5-Smc6 complex//integral component of membrane//glucosidase II complex KOG4208 Nucleolar RNA-binding protein NIFK Cluster-8309.43331 BF_2 308.28 3.30 4190 642912156 XP_008200829.1 841 8.2e-87 PREDICTED: tetraspanin-13 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17356 TSPAN13_31 tetraspanin-13/31 http://www.genome.jp/dbget-bin/www_bget?ko:K17356 Q5XHG6 499 1.5e-48 Tetraspanin-31-A OS=Xenopus laevis GN=tspan31-a PE=2 SV=1 PF00076//PF11654//PF11837//PF00335//PF07574 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Protein of unknown function (DUF2665)//Domain of unknown function (DUF3357)//Tetraspanin family//Nse1 non-SMC component of SMC5-6 complex GO:0009306//GO:0006281//GO:0005982//GO:0006012//GO:0005985 protein secretion//DNA repair//starch metabolic process//galactose metabolic process//sucrose metabolic process GO:0004564//GO:0003676//GO:0004575 beta-fructofuranosidase activity//nucleic acid binding//sucrose alpha-glucosidase activity GO:0017177//GO:0016021//GO:0030915 glucosidase II complex//integral component of membrane//Smc5-Smc6 complex KOG4208 Nucleolar RNA-binding protein NIFK Cluster-8309.43332 BF_2 36.67 0.58 2924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43334 BF_2 9.00 0.32 1455 357601612 EHJ63096.1 173 8.2e-10 putative piggyBac transposase Uribo1 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- -- -- Cluster-8309.43335 BF_2 38.85 0.34 5086 642918835 XP_008191606.1 3389 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 6.25431e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- A2RSQ0 1529 6.9e-168 DENN domain-containing protein 5B OS=Mus musculus GN=Dennd5b PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006269//GO:0006260//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated GO:0008270//GO:0003677//GO:0003896//GO:0005515 zinc ion binding//DNA binding//DNA primase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.43338 BF_2 461.65 2.89 6977 642912703 XP_008200968.1 4488 0.0e+00 PREDICTED: cytoskeleton-associated protein 5 [Tribolium castaneum]>gi|270002915|gb|EEZ99362.1| mini spindles [Tribolium castaneum] 642912702 XM_008202746.1 130 1.72066e-58 PREDICTED: Tribolium castaneum cytoskeleton-associated protein 5 (LOC659068), mRNA K16803 CKAP5, XMAP215 cytoskeleton-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16803 Q14008 1971 5.3e-219 Cytoskeleton-associated protein 5 OS=Homo sapiens GN=CKAP5 PE=1 SV=3 PF08465//PF02985//PF12422//PF11640 Thymidine kinase from Herpesvirus C-terminal//HEAT repeat//Condensin II non structural maintenance of chromosomes subunit//Telomere-length maintenance and DNA damage repair GO:0006206//GO:0016310//GO:0009069//GO:0006230 pyrimidine nucleobase metabolic process//phosphorylation//serine family amino acid metabolic process//TMP biosynthetic process GO:0004674//GO:0005515//GO:0004797//GO:0005524 protein serine/threonine kinase activity//protein binding//thymidine kinase activity//ATP binding GO:0005634 nucleus KOG1820 Microtubule-associated protein Cluster-8309.43339 BF_2 63.60 1.50 2063 546678750 ERL89302.1 1360 2.7e-147 hypothetical protein D910_06674 [Dendroctonus ponderosae] -- -- -- -- -- K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 -- -- -- -- PF05656//PF12106 Protein of unknown function (DUF805)//Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity GO:0016021 integral component of membrane -- -- Cluster-8309.43340 BF_2 19.00 0.48 1953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43341 BF_2 75.00 1.48 2410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43343 BF_2 722.07 2.85 10883 270005270 EFA01718.1 2859 0.0e+00 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] 642920291 XM_008194064.1 631 0 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 9-like (LOC664510), transcript variant X1, mRNA K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 Q3U1V8 1444 1.1e-157 Mitogen-activated protein kinase kinase kinase 9 OS=Mus musculus GN=Map3k9 PE=2 SV=2 PF00069//PF14604//PF00018//PF03938//PF07714//PF03102 Protein kinase domain//Variant SH3 domain//SH3 domain//Outer membrane protein (OmpH-like)//Protein tyrosine kinase//NeuB family GO:0016051//GO:0006468 carbohydrate biosynthetic process//protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0051082 protein binding//protein kinase activity//ATP binding//unfolded protein binding -- -- -- -- Cluster-8309.43346 BF_2 1877.01 33.95 2600 642919248 XP_008191793.1 999 2.4e-105 PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|642919250|ref|XP_008191794.1| PREDICTED: zinc transporter 1 isoform X1 [Tribolium castaneum]>gi|270005765|gb|EFA02213.1| hypothetical protein TcasGA2_TC007872 [Tribolium castaneum] 170068618 XM_001868902.1 84 2.37113e-33 Culex quinquefasciatus cation efflux protein/ zinc transporter, mRNA K14688 SLC30A1, ZNT1 solute carrier family 30 (zinc transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14688 Q60738 372 5.1e-34 Zinc transporter 1 OS=Mus musculus GN=Slc30a1 PE=1 SV=1 PF01545 Cation efflux family GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane KOG1483 Zn2+ transporter ZNT1 and related Cd2+/Zn2+ transporters (cation diffusion facilitator superfamily) Cluster-8309.43347 BF_2 255.00 4.38 2723 642920080 XP_001816051.2 1083 4.6e-115 PREDICTED: uncharacterized protein LOC100142030 [Tribolium castaneum] 817217709 XM_012429347.1 55 3.28103e-17 PREDICTED: Orussus abietinus uncharacterized LOC105702077 (LOC105702077), transcript variant X3, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43348 BF_2 166.00 1.19 6144 270003480 EEZ99927.1 1716 4.2e-188 hypothetical protein TcasGA2_TC002723 [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 252 9.9e-20 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 PF03554//PF03110 UL73 viral envelope glycoprotein//SBP domain -- -- GO:0003677 DNA binding GO:0019031//GO:0005634 viral envelope//nucleus KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.43349 BF_2 27.76 0.37 3458 642911043 XP_008193521.1 1799 5.6e-198 PREDICTED: histone deacetylase 6 [Tribolium castaneum] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 1328 9.4e-145 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.43352 BF_2 1272.30 12.67 4488 642916691 XP_008192180.1 4543 0.0e+00 PREDICTED: membrane-bound transcription factor site-1 protease isoform X1 [Tribolium castaneum] 768954933 XM_003976835.2 102 4.05641e-43 PREDICTED: Takifugu rubripes membrane-bound transcription factor site-1 protease-like (LOC101078346), partial mRNA K08653 MBTPS1 membrane-bound transcription factor site-1 protease http://www.genome.jp/dbget-bin/www_bget?ko:K08653 Q9Z2A8 3338 0.0e+00 Membrane-bound transcription factor site-1 protease OS=Cricetulus griseus GN=MBTPS1 PE=1 SV=2 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.43354 BF_2 86.36 1.16 3390 270014651 EFA11099.1 3279 0.0e+00 hypothetical protein TcasGA2_TC004696 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63406 1651 3.3e-182 Guanine nucleotide exchange factor DBS OS=Rattus norvegicus GN=Mcf2l PE=1 SV=3 PF00621//PF00435 RhoGEF domain//Spectrin repeat GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.43356 BF_2 4543.21 44.48 4560 91077054 XP_966585.1 1457 3.3e-158 PREDICTED: probable transaldolase [Tribolium castaneum]>gi|270001740|gb|EEZ98187.1| hypothetical protein TcasGA2_TC000616 [Tribolium castaneum] 746851965 XM_011058220.1 116 6.80068e-51 PREDICTED: Acromyrmex echinatior probable transaldolase (LOC105147307), mRNA K00616 E2.2.1.2, talA, talB transaldolase http://www.genome.jp/dbget-bin/www_bget?ko:K00616 Q9EQS0 1175 6.9e-127 Transaldolase OS=Rattus norvegicus GN=Taldo1 PE=1 SV=2 PF00560//PF00646//PF00923//PF15966//PF02428//PF13855//PF12937 Leucine Rich Repeat//F-box domain//Transaldolase//F-box//Potato type II proteinase inhibitor family//Leucine rich repeat//F-box-like GO:0005975//GO:0006098 carbohydrate metabolic process//pentose-phosphate shunt GO:0005515//GO:0004801//GO:0004867 protein binding//sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity//serine-type endopeptidase inhibitor activity GO:0005737 cytoplasm KOG2772 Transaldolase Cluster-8309.43357 BF_2 13.49 0.38 1760 642920404 XP_008192334.1 397 1.1e-35 PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum]>gi|642920406|ref|XP_967709.2| PREDICTED: uncharacterized protein LOC664268 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43358 BF_2 241.13 3.23 3407 478250209 ENN70712.1 1705 4.4e-187 hypothetical protein YQE_12657, partial [Dendroctonus ponderosae]>gi|546683975|gb|ERL93709.1| hypothetical protein D910_10996 [Dendroctonus ponderosae] -- -- -- -- -- K14807 DDX51, DBP6 ATP-dependent RNA helicase DDX51/DBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K14807 P26802 957 9.7e-102 Probable ATP-dependent RNA helicase Dbp73D OS=Drosophila melanogaster GN=Dbp73D PE=2 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0350 DEAD-box ATP-dependent RNA helicase Cluster-8309.43360 BF_2 281.54 12.63 1220 642917784 XP_008191285.1 743 5.5e-76 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X2 [Tribolium castaneum] -- -- -- -- -- K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 637 4.5e-65 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF08332 Calcium/calmodulin dependent protein kinase II association domain GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004683//GO:0005516 calmodulin-dependent protein kinase activity//calmodulin binding -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.43361 BF_2 183.21 0.85 9352 642930846 XP_008196111.1 677 1.9e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43362 BF_2 42.52 0.37 5058 642928921 XP_008195617.1 6951 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] 642928920 XM_008197395.1 1020 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 3949 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF02985//PF00443 HEAT repeat//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0005515 ubiquitinyl hydrolase activity//protein binding -- -- -- -- Cluster-8309.43366 BF_2 31.12 1.40 1219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43367 BF_2 45.25 0.38 5275 642924833 XP_008194059.1 824 9.7e-85 PREDICTED: IST1 homolog isoform X4 [Tribolium castaneum]>gi|270008007|gb|EFA04455.1| hypothetical protein TcasGA2_TC014759 [Tribolium castaneum] -- -- -- -- -- K19476 IST1 vacuolar protein sorting-associated protein IST1 http://www.genome.jp/dbget-bin/www_bget?ko:K19476 Q3ZBV1 568 1.9e-56 IST1 homolog OS=Bos taurus GN=IST1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2027 Spindle pole body protein Cluster-8309.43371 BF_2 588.29 5.08 5133 642924827 XP_008194056.1 824 9.4e-85 PREDICTED: IST1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K19476 IST1 vacuolar protein sorting-associated protein IST1 http://www.genome.jp/dbget-bin/www_bget?ko:K19476 Q3ZBV1 568 1.9e-56 IST1 homolog OS=Bos taurus GN=IST1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2027 Spindle pole body protein Cluster-8309.43373 BF_2 17710.15 557.10 1617 642928332 XP_008195538.1 991 1.3e-104 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81139 364 2.7e-33 Pancreatic lipase-related protein 2 OS=Cavia porcellus GN=PNLIPRP2 PE=1 SV=1 PF00975//PF01764//PF00326//PF06821//PF07819//PF07859 Thioesterase domain//Lipase (class 3)//Prolyl oligopeptidase family//Serine hydrolase//PGAP1-like protein//alpha/beta hydrolase fold GO:0006886//GO:0006629//GO:0006505//GO:0008152//GO:0009058//GO:0006508 intracellular protein transport//lipid metabolic process//GPI anchor metabolic process//metabolic process//biosynthetic process//proteolysis GO:0016787//GO:0016788//GO:0008236 hydrolase activity//hydrolase activity, acting on ester bonds//serine-type peptidase activity -- -- -- -- Cluster-8309.43374 BF_2 653.75 29.70 1208 642928332 XP_008195538.1 647 7.4e-65 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q17RR3 280 1.1e-23 Pancreatic lipase-related protein 3 OS=Homo sapiens GN=PNLIPRP3 PE=2 SV=2 PF01764//PF06821//PF00326//PF07819//PF00975 Lipase (class 3)//Serine hydrolase//Prolyl oligopeptidase family//PGAP1-like protein//Thioesterase domain GO:0009058//GO:0006508//GO:0006629//GO:0006886//GO:0006505 biosynthetic process//proteolysis//lipid metabolic process//intracellular protein transport//GPI anchor metabolic process GO:0008236//GO:0016788//GO:0016787 serine-type peptidase activity//hydrolase activity, acting on ester bonds//hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.43375 BF_2 5.79 0.94 546 826436136 XP_012529352.1 607 1.5e-60 PREDICTED: ubiquitin-conjugating enzyme E2 G2 [Monomorium pharaonis] 827562182 XM_004933089.2 86 3.66e-35 PREDICTED: Bombyx mori ubiquitin-conjugating enzyme E2 G2 (LOC101745353), mRNA K04555 UBE2G2, UBC7 ubiquitin-conjugating enzyme E2 G2 http://www.genome.jp/dbget-bin/www_bget?ko:K04555 Q17QG5 542 2.1e-54 Ubiquitin-conjugating enzyme E2 G2 OS=Bos taurus GN=UBE2G2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0426 Ubiquitin-protein ligase Cluster-8309.43376 BF_2 244.00 9.03 1417 91090934 XP_974343.1 871 9.2e-91 PREDICTED: ribosome maturation protein SBDS [Tribolium castaneum]>gi|270013208|gb|EFA09656.1| hypothetical protein TcasGA2_TC011782 [Tribolium castaneum] -- -- -- -- -- K14574 SDO1, SBDS ribosome maturation protein SDO1 http://www.genome.jp/dbget-bin/www_bget?ko:K14574 Q3SWZ6 774 6.7e-81 Ribosome maturation protein SBDS OS=Bos taurus GN=SBDS PE=2 SV=1 PF09377 SBDS protein C-terminal domain GO:0042254 ribosome biogenesis -- -- -- -- KOG2917 Predicted exosome subunit Cluster-8309.43377 BF_2 1467.36 11.37 5688 642936070 XP_008198290.1 2843 0.0e+00 PREDICTED: protein phosphatase Slingshot isoform X2 [Tribolium castaneum] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1461 5.9e-160 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.43378 BF_2 473.78 3.40 6119 91090936 XP_974392.1 3149 0.0e+00 PREDICTED: protein phosphatase Slingshot isoform X1 [Tribolium castaneum] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1461 6.3e-160 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.43379 BF_2 2763.94 20.43 5947 270014017 EFA10465.1 3006 0.0e+00 hypothetical protein TcasGA2_TC012711 [Tribolium castaneum] -- -- -- -- -- K05766 SSH protein phosphatase slingshot http://www.genome.jp/dbget-bin/www_bget?ko:K05766 Q6NN85 1461 6.1e-160 Protein phosphatase Slingshot OS=Drosophila melanogaster GN=ssh PE=1 SV=2 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.4338 BF_2 11.00 0.63 1012 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43380 BF_2 7.00 1.03 571 546682338 ERL92286.1 180 4.9e-11 hypothetical protein D910_09603 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43381 BF_2 1838.13 5.13 15273 642931869 XP_008196762.1 2259 1.1e-250 PREDICTED: protein split ends isoform X1 [Tribolium castaneum] 642931870 XM_008198541.1 278 2.0151e-140 PREDICTED: Tribolium castaneum protein split ends (LOC661278), transcript variant X2, mRNA -- -- -- -- Q8SX83 1148 3.1e-123 Protein split ends OS=Drosophila melanogaster GN=spen PE=1 SV=2 PF00335//PF04406//PF02532//PF16367//PF00076 Tetraspanin family//Type IIB DNA topoisomerase//Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006259//GO:0015979 DNA metabolic process//photosynthesis GO:0003676//GO:0005524//GO:0003824//GO:0003677 nucleic acid binding//ATP binding//catalytic activity//DNA binding GO:0005694//GO:0016020//GO:0009539//GO:0009523//GO:0016021 chromosome//membrane//photosystem II reaction center//photosystem II//integral component of membrane KOG0112 Large RNA-binding protein (RRM superfamily) Cluster-8309.43382 BF_2 688.78 11.12 2878 642929390 XP_008195816.1 919 5.1e-96 PREDICTED: cysteine dioxygenase type 1 [Tribolium castaneum]>gi|270010522|gb|EFA06970.1| hypothetical protein TcasGA2_TC009929 [Tribolium castaneum] -- -- -- -- -- K00456 CDO1 cysteine dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00456 Q6NWZ9 594 1.0e-59 Cysteine dioxygenase type 1 OS=Danio rerio GN=cdo1 PE=2 SV=1 PF07847//PF05995 Protein of unknown function (DUF1637)//Cysteine dioxygenase type I GO:0055114//GO:0019530//GO:0006534//GO:0046439 oxidation-reduction process//taurine metabolic process//cysteine metabolic process//L-cysteine metabolic process GO:0016702//GO:0017172//GO:0005506 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//cysteine dioxygenase activity//iron ion binding -- -- KOG4064 Cysteine dioxygenase CDO1 Cluster-8309.43383 BF_2 27.04 0.33 3711 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43385 BF_2 159.97 4.15 1899 642926542 XP_008194914.1 1359 3.2e-147 PREDICTED: LOW QUALITY PROTEIN: arginine-glutamic acid dipeptide repeats protein [Tribolium castaneum] 766941684 XM_011505186.1 56 6.33036e-18 PREDICTED: Ceratosolen solmsi marchali arginine-glutamic acid dipeptide repeats protein (LOC105366667), mRNA K05628 RERE arginine-glutamic acid dipeptide repeats protein http://www.genome.jp/dbget-bin/www_bget?ko:K05628 Q80TZ9 151 1.6e-08 Arginine-glutamic acid dipeptide repeats protein OS=Mus musculus GN=Rere PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43387 BF_2 13.22 0.74 1034 531445261 AGT57839.1 325 1.4e-27 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V6D6 193 1.2e-13 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.43388 BF_2 5.00 1.33 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43390 BF_2 1123.76 5.41 8973 642912276 XP_008200634.1 5209 0.0e+00 PREDICTED: exportin-7 isoform X2 [Tribolium castaneum]>gi|270002549|gb|EEZ98996.1| hypothetical protein TcasGA2_TC004857 [Tribolium castaneum] 642912275 XM_008202412.1 982 0 PREDICTED: Tribolium castaneum exportin-7 (LOC655656), transcript variant X2, mRNA K18460 XPO7, EXP7 exportin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18460 Q5ZLT0 4020 0.0e+00 Exportin-7 OS=Gallus gallus GN=XPO7 PE=2 SV=1 PF03810//PF13414 Importin-beta N-terminal domain//TPR repeat GO:0006886//GO:0015031 intracellular protein transport//protein transport GO:0008565//GO:0005515//GO:0008536 protein transporter activity//protein binding//Ran GTPase binding GO:0005643 nuclear pore KOG1410 Nuclear transport receptor RanBP16 (importin beta superfamily) Cluster-8309.43393 BF_2 121.22 2.45 2355 189237332 XP_973384.2 1276 1.7e-137 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 7.82345e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.0e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.43395 BF_2 80.51 0.66 5368 642920590 XP_008192477.1 719 1.5e-72 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 605 1.0e-60 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF00837//PF02230//PF12740//PF04083 Iodothyronine deiodinase//Phospholipase/Carboxylesterase//Chlorophyllase enzyme//Partial alpha/beta-hydrolase lipase region GO:0015996//GO:0006629//GO:0055114//GO:0015994 chlorophyll catabolic process//lipid metabolic process//oxidation-reduction process//chlorophyll metabolic process GO:0016787//GO:0004800//GO:0047746 hydrolase activity//thyroxine 5'-deiodinase activity//chlorophyllase activity -- -- -- -- Cluster-8309.43396 BF_2 20.20 1.06 1086 91094947 XP_968721.1 1020 3.7e-108 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5F3L4 728 1.1e-75 Protein DENND6A OS=Gallus gallus GN=DENND6A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.43397 BF_2 51.14 1.54 1678 642924836 XP_008194060.1 863 9.3e-90 PREDICTED: regucalcin-like isoform X1 [Tribolium castaneum]>gi|642924838|ref|XP_008194061.1| PREDICTED: regucalcin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 433 2.8e-41 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43398 BF_2 89.00 12.05 596 91092202 XP_969503.1 736 1.7e-75 PREDICTED: protein MEF2BNB homolog isoform X1 [Tribolium castaneum]>gi|270014438|gb|EFA10886.1| hypothetical protein TcasGA2_TC001710 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IR45 425 8.3e-41 Protein MEF2BNB homolog OS=Drosophila melanogaster GN=CG32590 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43399 BF_2 1538.86 29.78 2449 642924836 XP_008194060.1 879 1.9e-91 PREDICTED: regucalcin-like isoform X1 [Tribolium castaneum]>gi|642924838|ref|XP_008194061.1| PREDICTED: regucalcin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9TTJ5 418 2.2e-39 Regucalcin OS=Bos taurus GN=RGN PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43400 BF_2 250.70 3.08 3693 91092348 XP_971306.1 1293 2.8e-139 PREDICTED: uncharacterized protein LOC659947 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01601 Coronavirus S2 glycoprotein GO:0061025//GO:0046813 membrane fusion//receptor-mediated virion attachment to host cell -- -- GO:0016021//GO:0019031 integral component of membrane//viral envelope -- -- Cluster-8309.43401 BF_2 180.00 13.05 864 91077572 XP_972780.1 762 2.5e-78 PREDICTED: 39S ribosomal protein L46, mitochondrial [Tribolium castaneum] -- -- -- -- -- K17427 MRPL46 large subunit ribosomal protein L46 http://www.genome.jp/dbget-bin/www_bget?ko:K17427 Q5RK00 453 6.8e-44 39S ribosomal protein L46, mitochondrial OS=Rattus norvegicus GN=Mrpl46 PE=2 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4548 Mitochondrial ribosomal protein L17 Cluster-8309.43402 BF_2 414.80 5.87 3241 642920454 XP_008192357.1 1382 1.2e-149 PREDICTED: protein croquemort isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27367 956 1.2e-101 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43403 BF_2 2042.66 32.54 2913 91083737 XP_970914.1 1523 4.7e-166 PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|642924379|ref|XP_008194272.1| PREDICTED: uncharacterized protein LOC659522 [Tribolium castaneum]>gi|270007890|gb|EFA04338.1| hypothetical protein TcasGA2_TC014632 [Tribolium castaneum] -- -- -- -- -- K00815 TAT tyrosine aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00815 Q8QZR1 889 6.4e-94 Tyrosine aminotransferase OS=Mus musculus GN=Tat PE=1 SV=1 PF01212//PF01053//PF00155//PF02854 Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//Aminotransferase class I and II//MIF4G domain GO:0016070//GO:0009058//GO:0006520 RNA metabolic process//biosynthetic process//cellular amino acid metabolic process GO:0003723//GO:0003677//GO:0030170//GO:0005515//GO:0016829 RNA binding//DNA binding//pyridoxal phosphate binding//protein binding//lyase activity -- -- KOG0259 Tyrosine aminotransferase Cluster-8309.43404 BF_2 9920.18 115.09 3893 478254062 ENN74354.1 272 7.3e-21 hypothetical protein YQE_09324, partial [Dendroctonus ponderosae]>gi|546672807|gb|ERL84563.1| hypothetical protein D910_01992 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43410 BF_2 400.91 2.52 6955 189241642 XP_970294.2 3267 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X1 [Tribolium castaneum] 642937292 XM_965201.3 298 6.9764e-152 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X1, mRNA -- -- -- -- Q70EL1 1065 6.0e-114 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF00126//PF00443 Bacterial regulatory helix-turn-helix protein, lysR family//Ubiquitin carboxyl-terminal hydrolase GO:0016579//GO:0006355 protein deubiquitination//regulation of transcription, DNA-templated GO:0003700//GO:0036459 transcription factor activity, sequence-specific DNA binding//ubiquitinyl hydrolase activity GO:0005667 transcription factor complex KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.43417 BF_2 46.39 5.53 638 642931516 XP_001808926.2 221 9.8e-16 PREDICTED: uncharacterized protein LOC100141678 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08650 DASH complex subunit Dad4 GO:0008608 attachment of spindle microtubules to kinetochore -- -- GO:0072686//GO:0042729 mitotic spindle//DASH complex -- -- Cluster-8309.43418 BF_2 133.08 0.96 6090 332372732 AEE61508.1 572 1.9e-55 unknown [Dendroctonus ponderosae]>gi|546675468|gb|ERL86656.1| hypothetical protein D910_04062 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 396 2.0e-36 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF03370//PF15826//PF00191//PF08294//PF02936 Carbohydrate/starch-binding module (family 21)//Bcl-2-binding component 3, p53 upregulated modulator of apoptosis//Annexin//TIM21//Cytochrome c oxidase subunit IV GO:0030150//GO:0006123//GO:0097193//GO:0043065//GO:0015992//GO:0090200 protein import into mitochondrial matrix//mitochondrial electron transport, cytochrome c to oxygen//intrinsic apoptotic signaling pathway//positive regulation of apoptotic process//proton transport//positive regulation of release of cytochrome c from mitochondria GO:0005515//GO:0004129//GO:0005544//GO:0005509 protein binding//cytochrome-c oxidase activity//calcium-dependent phospholipid binding//calcium ion binding GO:0045277//GO:0005744//GO:0005739 respiratory chain complex IV//mitochondrial inner membrane presequence translocase complex//mitochondrion KOG0819 Annexin Cluster-8309.43419 BF_2 396.86 2.73 6369 642936968 XP_008198633.1 774 7.4e-79 PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936970|ref|XP_008198634.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936972|ref|XP_008198636.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936974|ref|XP_008198637.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum]>gi|642936976|ref|XP_008198638.1| PREDICTED: bromodomain-containing protein 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13709 137 2.2e-06 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 PF01397//PF04055 Terpene synthase, N-terminal domain//Radical SAM superfamily GO:0008152 metabolic process GO:0016829//GO:0010333//GO:0003824//GO:0051536 lyase activity//terpene synthase activity//catalytic activity//iron-sulfur cluster binding -- -- -- -- Cluster-8309.43422 BF_2 238.78 2.54 4220 642918982 XP_008191684.1 4673 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.31414e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.43423 BF_2 10812.37 362.18 1536 264667393 ACY71282.1 1027 8.2e-109 ribosomal protein S5 [Chrysomela tremula] 269118352 GQ865409.1 223 7.45718e-111 Catacroptera cloanthe voucher NW88-1 ribosomal protein S5 (RpS5) gene, partial cds K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q5E988 942 2.4e-100 40S ribosomal protein S5 OS=Bos taurus GN=RPS5 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3291 Ribosomal protein S7 Cluster-8309.43424 BF_2 85.48 0.52 7222 642918773 XP_008191578.1 3024 0.0e+00 PREDICTED: calpain-D-like isoform X2 [Tribolium castaneum] 194768179 XM_001966155.1 141 1.3674e-64 Drosophila ananassae GF19541 (Dana\GF19541), mRNA K08582 CAPN15 calpain-15 http://www.genome.jp/dbget-bin/www_bget?ko:K08582 P27398 1456 2.8e-159 Calpain-D OS=Drosophila melanogaster GN=sol PE=1 SV=2 PF00648//PF00641 Calpain family cysteine protease//Zn-finger in Ran binding protein and others GO:0006508 proteolysis GO:0008270//GO:0004198 zinc ion binding//calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.43427 BF_2 34.42 0.47 3370 642924682 XP_008194395.1 1980 5.6e-219 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 612 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1238 2.5e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF12052//PF08437//PF00018//PF01424 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal//SH3 domain//R3H domain GO:0009103//GO:0006816//GO:0070588 lipopolysaccharide biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0005515//GO:0003676//GO:0005245//GO:0008918 protein binding//nucleic acid binding//voltage-gated calcium channel activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.43428 BF_2 193.47 10.20 1081 270004596 EFA01044.1 1146 9.1e-123 hypothetical protein TcasGA2_TC003960 [Tribolium castaneum] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 587 2.5e-59 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.43429 BF_2 54.55 2.45 1219 546671620 ERL83854.1 1028 4.9e-109 hypothetical protein D910_01121 [Dendroctonus ponderosae] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 551 4.2e-55 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.43433 BF_2 2456.14 9.22 11435 642917156 XP_008191141.1 5897 0.0e+00 PREDICTED: filamin-A [Tribolium castaneum] -- -- -- -- -- K04437 FLNA filamin http://www.genome.jp/dbget-bin/www_bget?ko:K04437 Q14315 793 3.4e-82 Filamin-C OS=Homo sapiens GN=FLNC PE=1 SV=3 PF03110//PF03554//PF03547 SBP domain//UL73 viral envelope glycoprotein//Membrane transport protein GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0019031//GO:0005634//GO:0016021 viral envelope//nucleus//integral component of membrane KOG0518 Actin-binding cytoskeleton protein, filamin Cluster-8309.43436 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43438 BF_2 1.00 1.49 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43440 BF_2 1.00 10.51 232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43441 BF_2 1837.00 15.79 5153 478255854 ENN76062.1 464 5.3e-43 hypothetical protein YQE_07434, partial [Dendroctonus ponderosae]>gi|546680453|gb|ERL90719.1| hypothetical protein D910_08066 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q58D45 215 1.6e-15 Cell death-inducing p53-target protein 1 OS=Bos taurus GN=CDIP1 PE=2 SV=1 PF04113 Gpi16 subunit, GPI transamidase component GO:0016255 attachment of GPI anchor to protein -- -- GO:0042765 GPI-anchor transamidase complex -- -- Cluster-8309.43442 BF_2 114.00 15.39 597 478253101 ENN73474.1 270 1.9e-21 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02454 Sigma 1s protein GO:0019048 modulation by virus of host morphology or physiology -- -- -- -- -- -- Cluster-8309.43443 BF_2 82.57 0.49 7305 642935187 XP_008199684.1 1340 2.0e-144 PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|642935189|ref|XP_008199685.1| PREDICTED: cystinosin homolog [Tribolium castaneum]>gi|270014202|gb|EFA10650.1| hypothetical protein TcasGA2_TC016287 [Tribolium castaneum] 558226116 XM_006137153.1 62 1.13958e-20 PREDICTED: Pelodiscus sinensis tetratricopeptide repeat domain 1 (TTC1), transcript variant X3, mRNA K12386 CTNS cystinosin http://www.genome.jp/dbget-bin/www_bget?ko:K12386 Q9VCR7 1014 5.1e-108 Cystinosin homolog OS=Drosophila melanogaster GN=CG17119 PE=1 SV=2 PF13374//PF00515//PF13371//PF04194//PF13176//PF00522//PF13414//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Programmed cell death protein 2, C-terminal putative domain//Tetratricopeptide repeat//VPR/VPX protein//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0019058 viral life cycle GO:0005515 protein binding GO:0042025//GO:0005737 host cell nucleus//cytoplasm KOG3145 Cystine transporter Cystinosin Cluster-8309.43444 BF_2 41.85 0.37 5008 642926401 XP_008191947.1 3150 0.0e+00 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 635 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 1612 1.6e-177 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF03846//PF00105//PF00104 Cell division inhibitor SulA//Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0007165//GO:0009432//GO:0051782//GO:0006355//GO:0043401 signal transduction//SOS response//negative regulation of cell division//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003707//GO:0046872//GO:0003700//GO:0008270//GO:0043565 steroid hormone receptor activity//metal ion binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0009276//GO:0005634 transcription factor complex//Gram-negative-bacterium-type cell wall//nucleus -- -- Cluster-8309.43447 BF_2 217.88 2.42 4050 642912309 XP_008200644.1 1302 2.8e-140 PREDICTED: glycerol-3-phosphate acyltransferase 4 isoform X2 [Tribolium castaneum] 545878863 XM_005672663.1 113 2.80736e-49 PREDICTED: Sus scrofa 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta) (AGPAT6), transcript variant X2, mRNA K13506 GPAT3_4, AGPAT9, AGPAT6 glycerol-3-phosphate O-acyltransferase 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K13506 Q8K2C8 926 4.6e-98 Glycerol-3-phosphate acyltransferase 4 OS=Mus musculus GN=Agpat6 PE=2 SV=1 PF00481//PF03073//PF02812//PF01553//PF01699 Protein phosphatase 2C//TspO/MBR family//Glu/Leu/Phe/Val dehydrogenase, dimerisation domain//Acyltransferase//Sodium/calcium exchanger protein GO:0055114//GO:0006520//GO:0008152//GO:0055085 oxidation-reduction process//cellular amino acid metabolic process//metabolic process//transmembrane transport GO:0003824//GO:0016746//GO:0016491 catalytic activity//transferase activity, transferring acyl groups//oxidoreductase activity GO:0016021 integral component of membrane KOG2898 Predicted phosphate acyltransferase, contains PlsC domain Cluster-8309.43448 BF_2 2.00 2.92 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43449 BF_2 467.95 3.94 5251 478255990 ENN76189.1 1139 2.9e-121 hypothetical protein YQE_07157, partial [Dendroctonus ponderosae] 755992161 XM_011314822.1 134 7.72929e-61 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 710 6.6e-73 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00549//PF13508//PF00583//PF08445//PF13673 CoA-ligase//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein//Acetyltransferase (GNAT) domain GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0008080//GO:0016747 catalytic activity//N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.43452 BF_2 273.57 2.54 4791 189238796 XP_974873.2 4310 0.0e+00 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] 817212881 XM_012427217.1 176 3.16493e-84 PREDICTED: Orussus abietinus paired amphipathic helix protein Sin3a (LOC105700923), transcript variant X6, mRNA K11644 SIN3A paired amphipathic helix protein Sin3a http://www.genome.jp/dbget-bin/www_bget?ko:K11644 Q96ST3 1682 1.2e-185 Paired amphipathic helix protein Sin3a OS=Homo sapiens GN=SIN3A PE=1 SV=2 PF06390//PF02671 Neuroendocrine-specific golgi protein P55 (NESP55)//Paired amphipathic helix repeat GO:0006355//GO:0071107 regulation of transcription, DNA-templated//response to parathyroid hormone -- -- GO:0005634 nucleus KOG4204 Histone deacetylase complex, SIN3 component Cluster-8309.43453 BF_2 992.23 10.93 4083 189238796 XP_974873.2 4310 0.0e+00 PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|642927324|ref|XP_008195221.1| PREDICTED: paired amphipathic helix protein Sin3b [Tribolium castaneum]>gi|270009983|gb|EFA06431.1| hypothetical protein TcasGA2_TC009311 [Tribolium castaneum] 817212881 XM_012427217.1 176 2.69369e-84 PREDICTED: Orussus abietinus paired amphipathic helix protein Sin3a (LOC105700923), transcript variant X6, mRNA K11644 SIN3A paired amphipathic helix protein Sin3a http://www.genome.jp/dbget-bin/www_bget?ko:K11644 Q96ST3 1682 1.0e-185 Paired amphipathic helix protein Sin3a OS=Homo sapiens GN=SIN3A PE=1 SV=2 PF06390//PF02671 Neuroendocrine-specific golgi protein P55 (NESP55)//Paired amphipathic helix repeat GO:0006355//GO:0071107 regulation of transcription, DNA-templated//response to parathyroid hormone -- -- GO:0005634 nucleus KOG4204 Histone deacetylase complex, SIN3 component Cluster-8309.43454 BF_2 3.89 11.22 271 642929424 XP_008195834.1 330 9.4e-29 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07022//PF04218//PF01527 Bacteriophage CI repressor helix-turn-helix domain//CENP-B N-terminal DNA-binding domain//Transposase GO:0045892//GO:0006313 negative regulation of transcription, DNA-templated//transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- -- -- Cluster-8309.43455 BF_2 293.31 0.64 19481 642929422 XP_008195833.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.7798e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.5e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF05577//PF16367//PF00076//PF08273//PF01221//PF01429//PF07647//PF01609//PF08926//PF11789//PF02198//PF04564//PF06638//PF00326//PF00400//PF00130//PF00536//PF00439//PF00628//PF14634//PF04574 Serine carboxypeptidase S28//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc-binding domain of primase-helicase//Dynein light chain type 1//Methyl-CpG binding domain//SAM domain (Sterile alpha motif)//Transposase DDE domain//Domain of unknown function (DUF1908)//Zinc-finger of the MIZ type in Nse subunit//Sterile alpha motif (SAM)/Pointed domain//U-box domain//Strabismus protein//Prolyl oligopeptidase family//WD domain, G-beta repeat//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif)//Bromodomain//PHD-finger//zinc-RING finger domain//Protein of unknown function (DUF592) GO:0007017//GO:0006355//GO:0006468//GO:0009069//GO:0006807//GO:0006351//GO:0006476//GO:0006313//GO:0006269//GO:0035556//GO:0006508//GO:0006342//GO:0007275//GO:0016310//GO:0016567 microtubule-based process//regulation of transcription, DNA-templated//protein phosphorylation//serine family amino acid metabolic process//nitrogen compound metabolic process//transcription, DNA-templated//protein deacetylation//transposition, DNA-mediated//DNA replication, synthesis of RNA primer//intracellular signal transduction//proteolysis//chromatin silencing//multicellular organismal development//phosphorylation//protein ubiquitination GO:0043565//GO:0008270//GO:0016811//GO:0003896//GO:0017136//GO:0000287//GO:0004386//GO:0003677//GO:0051287//GO:0005515//GO:0004674//GO:0008236//GO:0005524//GO:0003676//GO:0004803//GO:0004842 sequence-specific DNA binding//zinc ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//DNA primase activity//NAD-dependent histone deacetylase activity//magnesium ion binding//helicase activity//DNA binding//NAD binding//protein binding//protein serine/threonine kinase activity//serine-type peptidase activity//ATP binding//nucleic acid binding//transposase activity//ubiquitin-protein transferase activity GO:0005875//GO:0016021//GO:0005657//GO:0005634//GO:0005730//GO:0000118 microtubule associated complex//integral component of membrane//replication fork//nucleus//nucleolus//histone deacetylase complex KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.43457 BF_2 206.92 3.13 3053 646722695 KDR23609.1 3011 0.0e+00 Periodic tryptophan protein 2-like protein [Zootermopsis nevadensis] -- -- -- -- -- K14558 PWP2, UTP1 periodic tryptophan protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14558 Q15269 2291 1.8e-256 Periodic tryptophan protein 2 homolog OS=Homo sapiens GN=PWP2 PE=1 SV=2 PF08625//PF01764//PF02031//PF00400//PF04192//PF09142//PF04617 Utp13 specific WD40 associated domain//Lipase (class 3)//Streptomyces extracellular neutral proteinase (M7) family//WD domain, G-beta repeat//Utp21 specific WD40 associated putative domain//tRNA Pseudouridine synthase II, C terminal//Hox9 activation region GO:0006351//GO:0006629//GO:0006508//GO:0006364//GO:0009451//GO:0001522 transcription, DNA-templated//lipid metabolic process//proteolysis//rRNA processing//RNA modification//pseudouridine synthesis GO:0004222//GO:0003723//GO:0005515//GO:0008270//GO:0009982 metalloendopeptidase activity//RNA binding//protein binding//zinc ion binding//pseudouridine synthase activity GO:0005634//GO:0005576//GO:0032040 nucleus//extracellular region//small-subunit processome KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.43458 BF_2 198.02 9.93 1121 91089925 XP_972979.1 1326 1.3e-143 PREDICTED: target of rapamycin complex subunit lst8 [Tribolium castaneum] -- -- -- -- -- K08266 GBL G protein beta subunit-like http://www.genome.jp/dbget-bin/www_bget?ko:K08266 Q803V5 1081 1.3e-116 Target of rapamycin complex subunit lst8 OS=Danio rerio GN=mlst8 PE=2 SV=1 PF00400//PF02897 WD domain, G-beta repeat//Prolyl oligopeptidase, N-terminal beta-propeller domain -- -- GO:0070008//GO:0005515//GO:0004252 serine-type exopeptidase activity//protein binding//serine-type endopeptidase activity -- -- KOG0315 G-protein beta subunit-like protein (contains WD40 repeats) Cluster-8309.43461 BF_2 91.39 3.44 1397 642936242 XP_008198362.1 1634 3.1e-179 PREDICTED: polypyrimidine tract-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 781 1.0e-81 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.43462 BF_2 53.00 1.45 1817 642924469 XP_008194311.1 910 3.6e-95 PREDICTED: transcription factor Sox-2 [Tribolium castaneum]>gi|270008130|gb|EFA04578.1| Sox21b [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12336 SOX transcription factor GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.43463 BF_2 12.00 0.60 1130 -- -- -- -- -- 462380946 APGK01022171.1 36 4.88504e-07 Dendroctonus ponderosae Seq01022181, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43464 BF_2 6.00 0.86 578 37594780 AAQ94359.1 396 4.5e-36 Hsp90 [Opistophthalmus carinatus] 567219073 XM_006413103.1 39 5.21153e-09 Eutrema salsugineum hypothetical protein (EUTSA_v10024564mg) mRNA, complete cds K04079 htpG, HSP90A molecular chaperone HtpG http://www.genome.jp/dbget-bin/www_bget?ko:K04079 Q04619 388 1.6e-36 Heat shock cognate protein HSP 90-beta OS=Gallus gallus GN=HSP90AB1 PE=2 SV=1 PF00183 Hsp90 protein GO:0006950//GO:0006457 response to stress//protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding -- -- KOG0019 Molecular chaperone (HSP90 family) Cluster-8309.43465 BF_2 999.59 11.56 3904 91087975 XP_973241.1 1366 1.0e-147 PREDICTED: wiskott-Aldrich syndrome protein family member 3 [Tribolium castaneum]>gi|270012052|gb|EFA08500.1| hypothetical protein TcasGA2_TC006152 [Tribolium castaneum] -- -- -- -- -- K06220 WASF WAS protein family http://www.genome.jp/dbget-bin/www_bget?ko:K06220 Q9UPY6 601 2.1e-60 Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens GN=WASF3 PE=1 SV=2 PF03358//PF07415//PF02205 NADPH-dependent FMN reductase//Gammaherpesvirus latent membrane protein (LMP2) protein//WH2 motif GO:0019042 viral latency GO:0003779//GO:0016491 actin binding//oxidoreductase activity GO:0033644 host cell membrane KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.43466 BF_2 39.08 1.18 1671 91092400 XP_969218.1 697 1.6e-70 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 279 2.0e-23 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43467 BF_2 15.48 1.00 937 557018159 XP_006009466.1 304 3.4e-25 PREDICTED: uncharacterized protein LOC102349681 isoform X1 [Latimeria chalumnae]>gi|557018161|ref|XP_006009467.1| PREDICTED: uncharacterized protein LOC102349681 isoform X2 [Latimeria chalumnae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02419 PsbL protein GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.43468 BF_2 279.00 9.94 1461 91081949 XP_967168.1 561 8.4e-55 PREDICTED: uncharacterized protein C18orf19 homolog B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5CZQ0 302 3.7e-26 Uncharacterized protein C18orf19 homolog B OS=Danio rerio GN=zgc:113036 PE=2 SV=1 PF01442//PF00448//PF13361//PF01610//PF13965 Apolipoprotein A1/A4/E domain//SRP54-type protein, GTPase domain//UvrD-like helicase C-terminal domain//Transposase//dsRNA-gated channel SID-1 GO:0006869//GO:0006313//GO:0042157//GO:0015931//GO:0006614//GO:0033227 lipid transport//transposition, DNA-mediated//lipoprotein metabolic process//nucleobase-containing compound transport//SRP-dependent cotranslational protein targeting to membrane//dsRNA transport GO:0016787//GO:0003677//GO:0008289//GO:0005524//GO:0004803//GO:0051033//GO:0005525 hydrolase activity//DNA binding//lipid binding//ATP binding//transposase activity//RNA transmembrane transporter activity//GTP binding GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG4082 Uncharacterized conserved protein Cluster-8309.43470 BF_2 12.20 0.34 1768 741829513 AJA91072.1 1364 7.9e-148 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 981 8.3e-105 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.43473 BF_2 388.31 6.65 2730 546678697 ERL89265.1 1371 1.9e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.4e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43477 BF_2 403.00 18.80 1184 546680236 ERL90554.1 630 6.8e-63 hypothetical protein D910_07902 [Dendroctonus ponderosae] 667830835 XM_007781397.1 52 6.52966e-16 Coniosporium apollinis CBS 100218 hypothetical protein partial mRNA K10976 ERO1LB ERO1-like protein beta http://www.genome.jp/dbget-bin/www_bget?ko:K10976 Q9V3A6 428 7.4e-41 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0016671//GO:0003756 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//protein disulfide isomerase activity GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.43478 BF_2 191.07 6.04 1610 478250804 ENN71296.1 1183 7.0e-127 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10950 ERO1L ERO1-like protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10950 Q9V3A6 913 5.8e-97 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0016671//GO:0003756 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//protein disulfide isomerase activity GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.43479 BF_2 348.87 11.13 1598 478250804 ENN71296.1 1194 3.7e-128 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10950 ERO1L ERO1-like protein alpha http://www.genome.jp/dbget-bin/www_bget?ko:K10950 Q9V3A6 924 3.1e-98 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0003756//GO:0016671 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.4348 BF_2 1.00 1.96 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43481 BF_2 38.57 1.35 1484 642916321 XP_008190972.1 159 3.5e-08 PREDICTED: uncharacterized protein LOC103312341 [Tribolium castaneum] 642916320 XM_008192750.1 106 7.89231e-46 PREDICTED: Tribolium castaneum uncharacterized LOC103312341 (LOC103312341), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43483 BF_2 1.00 9.36 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43484 BF_2 70.69 2.78 1351 91084201 XP_967826.1 1338 6.2e-145 PREDICTED: cyclin-dependent kinase 1 [Tribolium castaneum] 697443056 XM_009666252.1 44 2.09412e-11 PREDICTED: Struthio camelus australis cyclin-dependent kinase 3 (CDK3), partial mRNA K02087 CDK1, CDC2 cyclin-dependent kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02087 P23572 1201 2.0e-130 Cyclin-dependent kinase 1 OS=Drosophila melanogaster GN=cdc2 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.43487 BF_2 179.07 0.86 8955 646710408 KDR15927.1 1192 3.5e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.74134e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.7e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.43489 BF_2 20.00 42.14 283 642936837 XP_008197842.1 273 4.0e-22 PREDICTED: calcium-activated potassium channel slowpoke isoform X3 [Tribolium castaneum] 195504713 XM_002099161.1 68 1.81314e-25 Drosophila yakuba GE23506 (Dyak\GE23506), partial mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 267 8.3e-23 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4349 BF_2 74.00 5.62 838 91092028 XP_969359.1 1008 7.1e-107 PREDICTED: mediator of RNA polymerase II transcription subunit 18 [Tribolium castaneum]>gi|270004688|gb|EFA01136.1| hypothetical protein TcasGA2_TC010359 [Tribolium castaneum] -- -- -- -- -- K15135 MED18 mediator of RNA polymerase II transcription subunit 18 http://www.genome.jp/dbget-bin/www_bget?ko:K15135 Q17IN5 732 2.9e-76 Mediator of RNA polymerase II transcription subunit 18 OS=Aedes aegypti GN=MED18 PE=3 SV=1 PF09637 Med18 protein GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3264 Uncharacterized conserved protein Cluster-8309.43490 BF_2 11.00 0.55 1117 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43491 BF_2 413.82 3.59 5114 270014651 EFA11099.1 3279 0.0e+00 hypothetical protein TcasGA2_TC004696 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63406 1651 4.9e-182 Guanine nucleotide exchange factor DBS OS=Rattus norvegicus GN=Mcf2l PE=1 SV=3 PF00806//PF00435//PF00018//PF14604//PF00621 Pumilio-family RNA binding repeat//Spectrin repeat//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089//GO:0003723 protein binding//Rho guanyl-nucleotide exchange factor activity//RNA binding -- -- -- -- Cluster-8309.43493 BF_2 64.00 1.50 2071 478254281 ENN74535.1 1199 1.3e-128 hypothetical protein YQE_08859, partial [Dendroctonus ponderosae]>gi|546679316|gb|ERL89803.1| hypothetical protein D910_07164 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q17EJ1 932 4.7e-99 Mitochondrial GTPase 1 OS=Aedes aegypti GN=AAEL003813 PE=3 SV=1 PF03193//PF10662//PF04548//PF00071//PF00503//PF05049//PF01926//PF08477//PF02421 Protein of unknown function, DUF258//Ethanolamine utilisation - propanediol utilisation//AIG1 family//Ras family//G-protein alpha subunit//Interferon-inducible GTPase (IIGP)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B GO:0007264//GO:0015684//GO:0007186//GO:0007165//GO:0006576 small GTPase mediated signal transduction//ferrous iron transport//G-protein coupled receptor signaling pathway//signal transduction//cellular biogenic amine metabolic process GO:0005525//GO:0004871//GO:0019001//GO:0003924//GO:0015093//GO:0005524//GO:0031683 GTP binding//signal transducer activity//guanyl nucleotide binding//GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//G-protein beta/gamma-subunit complex binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG2485 Conserved ATP/GTP binding protein Cluster-8309.43494 BF_2 121.92 1.01 5318 546676782 ERL87728.1 270 1.7e-20 hypothetical protein D910_05118 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43497 BF_2 66.00 21.29 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43499 BF_2 396.03 1.36 12506 642922986 XP_008200482.1 7208 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase TRIP12 isoform X2 [Tribolium castaneum] 642922985 XM_008202260.1 1251 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase TRIP12 (LOC658915), transcript variant X4, mRNA K10590 TRIP12 E3 ubiquitin-protein ligase TRIP12 http://www.genome.jp/dbget-bin/www_bget?ko:K10590 G5E870 4375 0.0e+00 E3 ubiquitin-protein ligase TRIP12 OS=Mus musculus GN=Trip12 PE=1 SV=1 PF13414//PF13176//PF13371//PF00515//PF13374//PF00514//PF13174//PF00632//PF04049//PF12470//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Armadillo/beta-catenin-like repeat//Tetratricopeptide repeat//HECT-domain (ubiquitin-transferase)//Anaphase promoting complex subunit 8 / Cdc23//Suppressor of Fused Gli/Ci N terminal binding domain//Tetratricopeptide repeat GO:0016567//GO:0030071 protein ubiquitination//regulation of mitotic metaphase/anaphase transition GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0170 E3 ubiquitin protein ligase Cluster-8309.43501 BF_2 581.00 284.11 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12326 N-glycosylation protein GO:0034599 cellular response to oxidative stress -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.43502 BF_2 471.94 9.88 2285 91091908 XP_966621.1 1119 2.6e-119 PREDICTED: ribosome production factor 2 homolog [Tribolium castaneum]>gi|270000797|gb|EEZ97244.1| hypothetical protein TcasGA2_TC011042 [Tribolium castaneum] -- -- -- -- -- K14847 RPF2 ribosome production factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14847 Q9VEB3 773 1.4e-80 Ribosome production factor 2 homolog OS=Drosophila melanogaster GN=CG7993 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3031 Protein required for biogenesis of the ribosomal 60S subunit Cluster-8309.43503 BF_2 1.00 2.06 284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43506 BF_2 56.37 0.43 5801 546686097 ERL95494.1 1149 2.2e-122 hypothetical protein D910_12756 [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.49629e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 661 3.5e-67 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF05733//PF06743 Tenuivirus/Phlebovirus nucleocapsid protein//FAST kinase-like protein, subdomain 1 -- -- GO:0003723//GO:0004672 RNA binding//protein kinase activity GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.43507 BF_2 207.74 1.02 8807 642927636 XP_008195344.1 4414 0.0e+00 PREDICTED: zinc finger FYVE domain-containing protein 26 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19027 ZFYVE26 zinc finger FYVE domain-containing protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K19027 Q9VGP1 855 1.7e-89 Zinc finger FYVE domain-containing protein 26 homolog OS=Drosophila melanogaster GN=CG5270 PE=1 SV=3 PF01363//PF02419//PF04805 FYVE zinc finger//PsbL protein//E10-like protein conserved region GO:0015979//GO:0055114 photosynthesis//oxidation-reduction process GO:0046872//GO:0016972 metal ion binding//thiol oxidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.43508 BF_2 307.53 4.74 2999 642933278 XP_008197355.1 1071 1.3e-113 PREDICTED: serine/threonine-protein kinase pakG isoform X2 [Tribolium castaneum] 817211936 XM_012426709.1 59 2.16216e-19 PREDICTED: Orussus abietinus uncharacterized LOC105700657 (LOC105700657), mRNA -- -- -- -- Q96NU1 194 2.6e-13 Sterile alpha motif domain-containing protein 11 OS=Homo sapiens GN=SAMD11 PE=2 SV=3 PF07647//PF00536//PF02198 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed domain -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.43509 BF_2 650.48 9.27 3224 642921426 XP_008192862.1 1545 1.5e-168 PREDICTED: kelch domain-containing protein 3 [Tribolium castaneum]>gi|270006295|gb|EFA02743.1| hypothetical protein TcasGA2_TC008474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYI2 940 8.6e-100 Kelch domain-containing protein 3 OS=Rattus norvegicus GN=Klhdc3 PE=2 SV=1 PF07646//PF03089//PF01344 Kelch motif//Recombination activating protein 2//Kelch motif GO:0006310 DNA recombination GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG0379 Kelch repeat-containing proteins Cluster-8309.43510 BF_2 101.92 3.89 1382 91093162 XP_967461.1 1374 4.3e-149 PREDICTED: nucleolar complex protein 4 homolog B [Tribolium castaneum]>gi|270012948|gb|EFA09396.1| hypothetical protein TcasGA2_TC004314 [Tribolium castaneum] -- -- -- -- -- K14771 NOC4, UTP19 U3 small nucleolar RNA-associated protein 19 http://www.genome.jp/dbget-bin/www_bget?ko:K14771 Q6NU91 432 3.0e-41 Nucleolar complex protein 4 homolog B OS=Xenopus laevis GN=noc4l-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2154 Predicted nucleolar protein involved in ribosome biogenesis Cluster-8309.43511 BF_2 208.54 2.44 3859 270012327 EFA08775.1 2527 2.4e-282 hypothetical protein TcasGA2_TC006465 [Tribolium castaneum] 642932319 XM_008198841.1 537 0 PREDICTED: Tribolium castaneum myosin 15 (LOC658144), mRNA K10361 MYO15 myosin XV http://www.genome.jp/dbget-bin/www_bget?ko:K10361 Q9UKN7 699 9.1e-72 Unconventional myosin-XV OS=Homo sapiens GN=MYO15A PE=1 SV=2 PF01716//PF00784 Manganese-stabilising protein / photosystem II polypeptide//MyTH4 domain GO:0015979//GO:0042549 photosynthesis//photosystem II stabilization GO:0005509 calcium ion binding GO:0019898//GO:0005856//GO:0009654//GO:0009523 extrinsic component of membrane//cytoskeleton//photosystem II oxygen evolving complex//photosystem II KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.43512 BF_2 85.44 3.27 1381 189234402 XP_974971.2 196 1.7e-12 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43513 BF_2 176.55 1.63 4822 91087699 XP_974256.1 950 2.2e-99 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 518 1.1e-50 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852//PF01036 Glycosyltransferase family 10 (fucosyltransferase) C-term//Bacteriorhodopsin-like protein GO:0070085//GO:0006486 glycosylation//protein glycosylation GO:0016757//GO:0008417 transferase activity, transferring glycosyl groups//fucosyltransferase activity GO:0005794//GO:0016020 Golgi apparatus//membrane KOG2619 Fucosyltransferase Cluster-8309.43514 BF_2 387.12 5.75 3105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43518 BF_2 43.13 1.07 1970 546676863 ERL87800.1 503 6.0e-48 hypothetical protein D910_05189, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43520 BF_2 38.23 0.57 3116 524899886 XP_005106369.1 502 1.2e-47 PREDICTED: E3 ubiquitin-protein ligase mind-bomb-like isoform X1 [Aplysia californica] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 313 4.2e-27 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF14634//PF00097//PF00569//PF15898//PF06701//PF13639//PF07663 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc finger, ZZ type//cGMP-dependent protein kinase interacting domain//Mib_herc2//Ring finger domain//Sorbitol phosphotransferase enzyme II C-terminus GO:0008643//GO:0009401//GO:0016567 carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//protein ubiquitination GO:0046872//GO:0008982//GO:0019901//GO:0008270//GO:0005515//GO:0004842 metal ion binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase binding//zinc ion binding//protein binding//ubiquitin-protein transferase activity GO:0009357//GO:0016021 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.43521 BF_2 297.28 2.65 4988 478250812 ENN71304.1 2974 0.0e+00 hypothetical protein YQE_12229, partial [Dendroctonus ponderosae] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1642 5.3e-181 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF00050//PF00093//PF05375//PF07648//PF02130//PF04584 Kazal-type serine protease inhibitor domain//von Willebrand factor type C domain//Pacifastin inhibitor (LCMII)//Kazal-type serine protease inhibitor domain//Uncharacterized protein family UPF0054//Poxvirus A28 family GO:0016032//GO:0006364 viral process//rRNA processing GO:0004222//GO:0030414//GO:0005515 metalloendopeptidase activity//peptidase inhibitor activity//protein binding GO:0019031 viral envelope -- -- Cluster-8309.43524 BF_2 253.00 6.03 2043 478255783 ENN75992.1 1775 2.0e-195 hypothetical protein YQE_07524, partial [Dendroctonus ponderosae]>gi|546680369|gb|ERL90648.1| hypothetical protein D910_07995 [Dendroctonus ponderosae] -- -- -- -- -- K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P09242 902 1.4e-95 Alkaline phosphatase, tissue-nonspecific isozyme OS=Mus musculus GN=Alpl PE=1 SV=2 PF00245//PF01663//PF01676//PF00884 Alkaline phosphatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Metalloenzyme superfamily//Sulfatase GO:0008152 metabolic process GO:0046872//GO:0016791//GO:0003824//GO:0008484 metal ion binding//phosphatase activity//catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.43530 BF_2 479.93 4.40 4853 282400162 NP_001164204.1 2375 1.3e-264 hexamerin 5 precursor [Tribolium castaneum]>gi|270012805|gb|EFA09253.1| hypothetical protein TcasGA2_TC006515 [Tribolium castaneum] 157137263 XM_001663913.1 48 4.57929e-13 Aedes aegypti AAEL013757-RA mRNA K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 Q17127 1337 1.2e-145 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 PF06951 Group XII secretory phospholipase A2 precursor (PLA2G12) GO:0009395//GO:0016042 phospholipid catabolic process//lipid catabolic process GO:0005509//GO:0004623 calcium ion binding//phospholipase A2 activity GO:0005576 extracellular region -- -- Cluster-8309.43531 BF_2 123.36 10.14 796 270002887 EEZ99334.1 630 4.6e-63 hypothetical protein TcasGA2_TC004551 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 393 5.7e-37 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.43534 BF_2 1303.61 12.09 4798 91084515 XP_967225.1 790 7.7e-81 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.43535 BF_2 93.37 1.14 3720 642939887 XP_008200200.1 3339 0.0e+00 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 643 2.7e-65 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF01442//PF06152//PF08236//PF03127 Apolipoprotein A1/A4/E domain//Phage minor capsid protein 2//SRI (Set2 Rpb1 interacting) domain//GAT domain GO:0006886//GO:0034968//GO:0006869//GO:0042157//GO:0006554//GO:0006479//GO:0006355 intracellular protein transport//histone lysine methylation//lipid transport//lipoprotein metabolic process//lysine catabolic process//protein methylation//regulation of transcription, DNA-templated GO:0005198//GO:0018024//GO:0008289 structural molecule activity//histone-lysine N-methyltransferase activity//lipid binding GO:0019028//GO:0005622//GO:0005694//GO:0005576 viral capsid//intracellular//chromosome//extracellular region KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.43536 BF_2 148.76 1.84 3672 642939889 XP_008200206.1 2499 4.0e-279 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 565 3.0e-56 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF04216//PF08236//PF07464//PF06152//PF01442 Protein involved in formate dehydrogenase formation//SRI (Set2 Rpb1 interacting) domain//Apolipophorin-III precursor (apoLp-III)//Phage minor capsid protein 2//Apolipoprotein A1/A4/E domain GO:0006479//GO:0006355//GO:0006554//GO:0042157//GO:0034968//GO:0006869 protein methylation//regulation of transcription, DNA-templated//lysine catabolic process//lipoprotein metabolic process//histone lysine methylation//lipid transport GO:0018024//GO:0008289//GO:0005198 histone-lysine N-methyltransferase activity//lipid binding//structural molecule activity GO:0005694//GO:0005576//GO:0005737//GO:0019028 chromosome//extracellular region//cytoplasm//viral capsid KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.43539 BF_2 2146.90 115.46 1065 478257747 ENN77890.1 970 2.3e-102 hypothetical protein YQE_05567, partial [Dendroctonus ponderosae]>gi|546677670|gb|ERL88464.1| hypothetical protein D910_05850 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05946 610 5.2e-62 Sarcoplasmic calcium-binding protein 1 OS=Astacus leptodactylus PE=1 SV=1 PF00036//PF13833//PF13405//PF13499//PF13202//PF09298 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Fumarylacetoacetase N-terminal GO:0042207//GO:0006570//GO:0009072 styrene catabolic process//tyrosine metabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005509 fumarylacetoacetase activity//calcium ion binding -- -- -- -- Cluster-8309.43542 BF_2 1513.19 18.21 3764 642920169 XP_008192230.1 3419 0.0e+00 PREDICTED: echinoderm microtubule-associated protein-like 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18595 EML1_2 echinoderm microtubule-associated protein-like 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K18595 Q4V8C3 1931 1.2e-214 Echinoderm microtubule-associated protein-like 1 OS=Rattus norvegicus GN=Eml1 PE=2 SV=2 PF00930//PF00400 Dipeptidyl peptidase IV (DPP IV) N-terminal region//WD domain, G-beta repeat GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG2106 Uncharacterized conserved protein, contains HELP and WD40 domains Cluster-8309.43543 BF_2 2953.67 70.77 2033 642936925 XP_008194485.1 1095 1.4e-116 PREDICTED: nuclear factor NF-kappa-B p110 subunit isoform X2 [Tribolium castaneum] -- -- -- -- -- K02580 NFKB1 nuclear factor NF-kappa-B p105 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02580 Q94527 264 1.3e-21 Nuclear factor NF-kappa-B p110 subunit OS=Drosophila melanogaster GN=Rel PE=1 SV=1 PF09494//PF00023//PF03776//PF13606 Slx4 endonuclease//Ankyrin repeat//Septum formation topological specificity factor MinE//Ankyrin repeat GO:0006281//GO:0051301//GO:0006260//GO:0006308//GO:0032955 DNA repair//cell division//DNA replication//DNA catabolic process//regulation of barrier septum assembly GO:0005515//GO:0017108 protein binding//5'-flap endonuclease activity GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex -- -- Cluster-8309.43546 BF_2 9.75 0.61 953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.43547 BF_2 37.06 0.33 4994 282400162 NP_001164204.1 1680 5.1e-184 hexamerin 5 precursor [Tribolium castaneum]>gi|270012805|gb|EFA09253.1| hypothetical protein TcasGA2_TC006515 [Tribolium castaneum] 157137263 XM_001663913.1 48 4.71333e-13 Aedes aegypti AAEL013757-RA mRNA K01047 PLA2G, SPLA2 secretory phospholipase A2 http://www.genome.jp/dbget-bin/www_bget?ko:K01047 Q17127 960 6.4e-102 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 PF06951 Group XII secretory phospholipase A2 precursor (PLA2G12) GO:0016042//GO:0009395 lipid catabolic process//phospholipid catabolic process GO:0005509//GO:0004623 calcium ion binding//phospholipase A2 activity GO:0005576 extracellular region -- -- Cluster-8309.43549 BF_2 612.99 6.54 4207 478257812 ENN77955.1 359 6.4e-31 hypothetical protein YQE_05632, partial [Dendroctonus ponderosae]>gi|546674589|gb|ERL85938.1| hypothetical protein D910_03353 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04135//PF01155 Nucleolar RNA-binding protein, Nop10p family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0001522//GO:0042254//GO:0006464 pseudouridine synthesis//ribosome biogenesis//cellular protein modification process GO:0016151//GO:0030515 nickel cation binding//snoRNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.43550 BF_2 1036.94 6.36 7105 194880788 XP_001974544.1 2122 4.0e-235 GG21804 [Drosophila erecta]>gi|190657731|gb|EDV54944.1| GG21804 [Drosophila erecta] 572319027 XM_006625008.1 56 2.39887e-17 PREDICTED: Apis dorsata E3 ubiquitin-protein ligase SMURF1-like (LOC102679083), mRNA K04678 SMURF E3 ubiquitin ligase SMURF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K04678 A9JRZ0 1867 6.1e-207 E3 ubiquitin-protein ligase SMURF2 OS=Danio rerio GN=smurf2 PE=2 SV=1 PF00168//PF00397//PF00632 C2 domain//WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.43551 BF_2 1394.00 31.73 2125 642927136 XP_972282.2 1355 1.0e-146 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0L6 377 1.1e-34 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Mus musculus GN=Paox PE=1 SV=3 PF00070//PF01134//PF05834//PF00732//PF01266//PF06389//PF12831//PF02254//PF01593//PF07992//PF01494 Pyridine nucleotide-disulphide oxidoreductase//Glucose inhibited division protein A//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase//Filovirus membrane-associated protein VP24//FAD dependent oxidoreductase//TrkA-N domain//Flavin containing amine oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain GO:0016117//GO:0055114//GO:0008033//GO:0016032//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//tRNA processing//viral process//potassium ion transport GO:0050660//GO:0016614//GO:0016705//GO:0071949//GO:0005198//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//structural molecule activity//oxidoreductase activity GO:0016020 membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.43553 BF_2 83.99 0.84 4475 642916588 XP_008191804.1 545 1.9e-52 PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum]>gi|642916590|ref|XP_008191810.1| PREDICTED: uncharacterized protein LOC103312586 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12597 AIR1_2 protein AIR1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12597 A1L2T6 239 2.3e-18 Zinc finger CCHC domain-containing protein 7 OS=Xenopus laevis GN=zcchc7 PE=2 SV=2 PF06331 Transcription factor TFIIH complex subunit Tfb5 GO:0006289//GO:0006355 nucleotide-excision repair//regulation of transcription, DNA-templated -- -- GO:0000439 core TFIIH complex KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.43556 BF_2 12.47 0.86 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.43557 BF_2 560.00 9.19 2837 91078462 XP_967648.1 2187 4.7e-243 PREDICTED: protein SGT1 homolog ecdysoneless [Tribolium castaneum]>gi|270004999|gb|EFA01447.1| hypothetical protein TcasGA2_TC030757 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W032 1156 6.8e-125 Protein ecdysoneless OS=Drosophila melanogaster GN=ecd PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2406 MADS box transcription factor Cluster-8309.43559 BF_2 556.91 18.82 1525 270003289 EEZ99736.1 1349 3.7e-146 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13678 128 5.9e-06 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF09202//PF00168 Phorbol esters/diacylglycerol binding domain (C1 domain)//Rio2, N-terminal//C2 domain GO:0035556//GO:0006468//GO:0009069//GO:0016310 intracellular signal transduction//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0005515 ATP binding//protein serine/threonine kinase activity//protein binding -- -- -- -- Cluster-8309.43560 BF_2 18.97 0.51 1853 642934675 XP_008197763.1 1026 1.3e-108 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 556762122 XM_005976302.1 89 2.7924e-36 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 779 2.3e-81 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.43561 BF_2 329.22 3.78 3935 642927786 XP_008195405.1 2733 3.1e-306 PREDICTED: pre-mRNA-processing factor 39 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13217 PRPF39, PRP39 pre-mRNA-processing factor 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13217 Q1JPZ7 1242 1.0e-134 Pre-mRNA-processing factor 39 OS=Danio rerio GN=prpf39 PE=2 SV=2 PF02184//PF13181//PF13174//PF13414//PF05843 HAT (Half-A-TPR) repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Suppressor of forked protein (Suf) GO:0006396//GO:0006397 RNA processing//mRNA processing GO:0005515 protein binding GO:0005622//GO:0005634 intracellular//nucleus KOG1258 mRNA processing protein Cluster-8309.43563 BF_2 47.55 0.48 4419 642927788 XP_008195406.1 2047 1.2e-226 PREDICTED: pre-mRNA-processing factor 39 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13217 PRPF39, PRP39 pre-mRNA-processing factor 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13217 Q1JPZ7 1005 3.4e-107 Pre-mRNA-processing factor 39 OS=Danio rerio GN=prpf39 PE=2 SV=2 PF13181//PF00515//PF02184//PF13414//PF02978//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//HAT (Half-A-TPR) repeat//TPR repeat//Signal peptide binding domain//Tetratricopeptide repeat GO:0006614//GO:0006396 SRP-dependent cotranslational protein targeting to membrane//RNA processing GO:0008312//GO:0005515 7S RNA binding//protein binding GO:0005622//GO:0048500 intracellular//signal recognition particle KOG1258 mRNA processing protein Cluster-8309.43564 BF_2 19.19 0.65 1522 642918444 XP_008191477.1 1526 1.1e-166 PREDICTED: transient receptor potential cation channel subfamily A member 1 [Tribolium castaneum] -- -- -- -- -- K04984 TRPA1, ANKTM1 transient receptor potential cation channel subfamily A member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04984 Q7Z020 1136 7.6e-123 Transient receptor potential cation channel subfamily A member 1 OS=Drosophila melanogaster GN=TrpA1 PE=2 SV=4 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.43565 BF_2 288.43 7.94 1806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43566 BF_2 184.38 2.14 3886 546685110 ERL94637.1 1750 3.0e-192 hypothetical protein D910_11912 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PCB5 1066 2.6e-114 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 PF06151 Trehalose receptor GO:0007607//GO:0050912//GO:0007187 obsolete taste perception//detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0008527 taste receptor activity GO:0016021 integral component of membrane KOG4425 Uncharacterized conserved protein Cluster-8309.43569 BF_2 968.58 14.83 3019 91086463 XP_969857.1 1953 6.7e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1237 2.9e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.43571 BF_2 136.81 1.06 5691 189240823 XP_001811917.1 3289 0.0e+00 PREDICTED: ATP-dependent RNA helicase SUV3 homolog, mitochondrial [Tribolium castaneum]>gi|270013711|gb|EFA10159.1| hypothetical protein TcasGA2_TC012348 [Tribolium castaneum] 755880618 XM_005185469.2 352 0 PREDICTED: Musca domestica ATP-dependent RNA helicase SUV3 homolog, mitochondrial (LOC101900390), mRNA K17675 SUPV3L1, SUV3 ATP-dependent RNA helicase SUPV3L1/SUV3 http://www.genome.jp/dbget-bin/www_bget?ko:K17675 Q9VN03 2699 1.6e-303 ATP-dependent RNA helicase SUV3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG9791 PE=2 SV=3 PF12513//PF11965//PF00001 Mitochondrial degradasome RNA helicase subunit C terminal//Domain of unknown function (DUF3479)//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0015994 G-protein coupled receptor signaling pathway//chlorophyll metabolic process GO:0003676//GO:0016851//GO:0016817//GO:0005524//GO:0004386//GO:0004930 nucleic acid binding//magnesium chelatase activity//hydrolase activity, acting on acid anhydrides//ATP binding//helicase activity//G-protein coupled receptor activity GO:0016021//GO:0010007 integral component of membrane//magnesium chelatase complex KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily Cluster-8309.43573 BF_2 100.17 1.31 3475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05241 Emopamil binding protein GO:0006694//GO:0016125 steroid biosynthetic process//sterol metabolic process GO:0047750 cholestenol delta-isomerase activity GO:0016021 integral component of membrane -- -- Cluster-8309.43582 BF_2 40.47 0.39 4658 270017210 EFA13656.1 560 3.5e-54 hypothetical protein TcasGA2_TC016129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YMJ7 216 1.1e-15 Envelope fusion protein OS=Lymantria dispar multicapsid nuclear polyhedrosis virus GN=LdOrf-130 PE=3 SV=1 PF07651//PF06009//PF03632//PF02601 ANTH domain//Laminin Domain II//Glycosyl hydrolase family 65 central catalytic domain//Exonuclease VII, large subunit GO:0007155//GO:0005975//GO:0006308 cell adhesion//carbohydrate metabolic process//DNA catabolic process GO:0003824//GO:0008855//GO:0005543 catalytic activity//exodeoxyribonuclease VII activity//phospholipid binding GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.43586 BF_2 4351.80 43.73 4450 91081213 XP_975619.1 894 6.3e-93 PREDICTED: proto-oncogene c-Fos isoform X2 [Tribolium castaneum]>gi|270006054|gb|EFA02502.1| hypothetical protein TcasGA2_TC008201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03131//PF07716//PF00170 bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.43588 BF_2 2228.12 27.88 3630 270011110 EFA07558.1 1124 1.1e-119 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 764 2.5e-79 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF08367//PF02949//PF08395//PF00089//PF04130 Peptidase M16C associated//7tm Odorant receptor//7tm Chemosensory receptor//Trypsin//Spc97 / Spc98 family GO:0007187//GO:0007608//GO:0050909//GO:0006508//GO:0000226//GO:0090063 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell//sensory perception of taste//proteolysis//microtubule cytoskeleton organization//positive regulation of microtubule nucleation GO:0005549//GO:0004984//GO:0004252 odorant binding//olfactory receptor activity//serine-type endopeptidase activity GO:0005815//GO:0016021//GO:0000922//GO:0016020 microtubule organizing center//integral component of membrane//spindle pole//membrane -- -- Cluster-8309.43589 BF_2 662.03 2.71 10518 91077334 XP_974850.1 2102 1.2e-232 PREDICTED: amidophosphoribosyltransferase [Tribolium castaneum]>gi|270001665|gb|EEZ98112.1| hypothetical protein TcasGA2_TC000530 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 1736 1.4e-191 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 PF07851//PF04632//PF04508//PF04728//PF01401//PF00038//PF05404//PF11380//PF04111//PF13405//PF02465//PF01166//PF10473//PF00156//PF00769//PF17060 TMPIT-like protein//Fusaric acid resistance protein family//Viral A-type inclusion protein repeat//Lipoprotein leucine-zipper//Angiotensin-converting enzyme//Intermediate filament protein//Translocon-associated protein, delta subunit precursor (TRAP-delta)//Stealth protein CR2, conserved region 2//Autophagy protein Apg6//EF-hand domain//Flagellar hook-associated protein 2 N-terminus//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Phosphoribosyl transferase domain//Ezrin/radixin/moesin family//Monopolar spindle protein 2 GO:0030474//GO:0016032//GO:0006508//GO:0006144//GO:0071988//GO:0006914//GO:0006536//GO:0009113//GO:0006810//GO:0006189//GO:0006541//GO:0006355//GO:0009116 spindle pole body duplication//viral process//proteolysis//purine nucleobase metabolic process//protein localization to spindle pole body//autophagy//glutamate metabolic process//purine nucleobase biosynthetic process//transport//'de novo' IMP biosynthetic process//glutamine metabolic process//regulation of transcription, DNA-templated//nucleoside metabolic process GO:0008092//GO:0046872//GO:0005509//GO:0008237//GO:0008134//GO:0045502//GO:0008241//GO:0004044//GO:0003700//GO:0016772//GO:0042803//GO:0005198//GO:0051536 cytoskeletal protein binding//metal ion binding//calcium ion binding//metallopeptidase activity//transcription factor binding//dynein binding//peptidyl-dipeptidase activity//amidophosphoribosyltransferase activity//transcription factor activity, sequence-specific DNA binding//transferase activity, transferring phosphorus-containing groups//protein homodimerization activity//structural molecule activity//iron-sulfur cluster binding GO:0005667//GO:0030286//GO:0009424//GO:0005882//GO:0019898//GO:0005783//GO:0019867//GO:0005886//GO:0016020//GO:0016021//GO:0005737 transcription factor complex//dynein complex//bacterial-type flagellum hook//intermediate filament//extrinsic component of membrane//endoplasmic reticulum//outer membrane//plasma membrane//membrane//integral component of membrane//cytoplasm KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.43591 BF_2 45.43 9.09 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43592 BF_2 102.67 1.79 2688 546678697 ERL89265.1 1371 1.8e-148 hypothetical protein D910_06638 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27367 710 3.4e-73 Protein croquemort OS=Drosophila melanogaster GN=crq PE=1 SV=2 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.43593 BF_2 67.00 2.72 1317 642929245 XP_008195751.1 329 6.1e-28 PREDICTED: poly [ADP-ribose] polymerase 11-like [Tribolium castaneum]>gi|270009669|gb|EFA06117.1| hypothetical protein TcasGA2_TC008960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2W4 186 9.5e-13 Zinc finger CCCH-type antiviral protein 1 OS=Homo sapiens GN=ZC3HAV1 PE=1 SV=3 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- -- -- Cluster-8309.43595 BF_2 292.42 3.68 3611 642920655 XP_008192506.1 3040 0.0e+00 PREDICTED: tetratricopeptide repeat protein 17 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E9PVB5 637 1.3e-64 Tetratricopeptide repeat protein 17 OS=Mus musculus GN=Ttc17 PE=2 SV=1 PF13181//PF08152//PF02468//PF13174//PF00515//PF13374//PF13371//PF13176//PF13414 Tetratricopeptide repeat//GUCT (NUC152) domain//Photosystem II reaction centre N protein (psbN)//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0015979 photosynthesis GO:0005515//GO:0003723//GO:0004386//GO:0005524 protein binding//RNA binding//helicase activity//ATP binding GO:0005634//GO:0009539//GO:0009523//GO:0016020 nucleus//photosystem II reaction center//photosystem II//membrane KOG4507 Uncharacterized conserved protein, contains TPR repeats Cluster-8309.43597 BF_2 1696.12 18.31 4163 642913615 XP_008201089.1 4124 0.0e+00 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X4 [Tribolium castaneum]>gi|270002050|gb|EEZ98497.1| hypothetical protein TcasGA2_TC000997 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q5PQN1 2385 3.1e-267 Probable E3 ubiquitin-protein ligase HERC4 OS=Rattus norvegicus GN=Herc4 PE=2 SV=1 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0941 E3 ubiquitin protein ligase Cluster-8309.43602 BF_2 189.75 1.56 5383 270010529 EFA06977.1 2726 2.8e-305 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929423 XM_008197612.1 391 0 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9UIF8 496 4.4e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF16866//PF13718//PF00628//PF01221//PF08926//PF00130//PF00439 PHD-finger//GNAT acetyltransferase 2//PHD-finger//Dynein light chain type 1//Domain of unknown function (DUF1908)//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain GO:0009069//GO:0006468//GO:0042967//GO:0016310//GO:0035556//GO:0007017 serine family amino acid metabolic process//protein phosphorylation//acyl-carrier-protein biosynthetic process//phosphorylation//intracellular signal transduction//microtubule-based process GO:0008080//GO:0005515//GO:0005524//GO:0000287//GO:0004674 N-acetyltransferase activity//protein binding//ATP binding//magnesium ion binding//protein serine/threonine kinase activity GO:0005875 microtubule associated complex KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.43603 BF_2 647.27 1.43 19246 642929424 XP_008195834.1 3477 0.0e+00 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X2 [Tribolium castaneum] 642929421 XM_008197611.1 179 2.7462e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA K01285 PRCP lysosomal Pro-X carboxypeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01285 Q7TMR0 1024 9.4e-109 Lysosomal Pro-X carboxypeptidase OS=Mus musculus GN=Prcp PE=2 SV=2 PF01221//PF08273//PF01429//PF05577//PF16367//PF00076//PF02198//PF04564//PF06638//PF07647//PF11789//PF08926//PF00400//PF00326//PF14634//PF00628//PF04574//PF00130//PF00536//PF00439 Dynein light chain type 1//Zinc-binding domain of primase-helicase//Methyl-CpG binding domain//Serine carboxypeptidase S28//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Sterile alpha motif (SAM)/Pointed domain//U-box domain//Strabismus protein//SAM domain (Sterile alpha motif)//Zinc-finger of the MIZ type in Nse subunit//Domain of unknown function (DUF1908)//WD domain, G-beta repeat//Prolyl oligopeptidase family//zinc-RING finger domain//PHD-finger//Protein of unknown function (DUF592)//Phorbol esters/diacylglycerol binding domain (C1 domain)//SAM domain (Sterile alpha motif)//Bromodomain GO:0006508//GO:0006342//GO:0007275//GO:0016567//GO:0016310//GO:0006269//GO:0035556//GO:0006807//GO:0006351//GO:0006476//GO:0007017//GO:0006355//GO:0009069//GO:0006468 proteolysis//chromatin silencing//multicellular organismal development//protein ubiquitination//phosphorylation//DNA replication, synthesis of RNA primer//intracellular signal transduction//nitrogen compound metabolic process//transcription, DNA-templated//protein deacetylation//microtubule-based process//regulation of transcription, DNA-templated//serine family amino acid metabolic process//protein phosphorylation GO:0003676//GO:0004842//GO:0008236//GO:0004674//GO:0005524//GO:0000287//GO:0004386//GO:0003677//GO:0051287//GO:0005515//GO:0008270//GO:0043565//GO:0016811//GO:0003896//GO:0017136 nucleic acid binding//ubiquitin-protein transferase activity//serine-type peptidase activity//protein serine/threonine kinase activity//ATP binding//magnesium ion binding//helicase activity//DNA binding//NAD binding//protein binding//zinc ion binding//sequence-specific DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//DNA primase activity//NAD-dependent histone deacetylase activity GO:0000118//GO:0005730//GO:0005657//GO:0005634//GO:0016021//GO:0005875 histone deacetylase complex//nucleolus//replication fork//nucleus//integral component of membrane//microtubule associated complex KOG2183 Prolylcarboxypeptidase (angiotensinase C) Cluster-8309.43607 BF_2 715.25 13.59 2489 332375116 AEE62699.1 2526 2.0e-282 unknown [Dendroctonus ponderosae]>gi|546676201|gb|ERL87268.1| hypothetical protein D910_04664 [Dendroctonus ponderosae] -- -- -- -- -- K12825 SF3A1, SAP114 splicing factor 3A subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12825 Q15459 1472 1.4e-161 Splicing factor 3A subunit 1 OS=Homo sapiens GN=SF3A1 PE=1 SV=1 PF01805//PF01093//PF00240 Surp module//Clusterin//Ubiquitin family GO:0008219//GO:0006396 cell death//RNA processing GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG0007 Splicing factor 3a, subunit 1 Cluster-8309.43609 BF_2 175.45 3.64 2301 91091438 XP_972410.1 2336 2.0e-260 PREDICTED: protein ST7 homolog [Tribolium castaneum]>gi|270000957|gb|EEZ97404.1| hypothetical protein TcasGA2_TC011233 [Tribolium castaneum] 759067333 XM_011344833.1 251 3.06436e-126 PREDICTED: Cerapachys biroi protein ST7 homolog (LOC105282664), mRNA -- -- -- -- Q9VPB1 2095 7.2e-234 Protein ST7 homolog OS=Drosophila melanogaster GN=CG3634 PE=2 SV=1 PF00637//PF13174//PF13414//PF13181//PF00515 Region in Clathrin and VPS//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding -- -- KOG3807 Predicted membrane protein ST7 (tumor suppressor in humans) Cluster-8309.43610 BF_2 178.55 3.67 2321 91091438 XP_972410.1 2336 2.0e-260 PREDICTED: protein ST7 homolog [Tribolium castaneum]>gi|270000957|gb|EEZ97404.1| hypothetical protein TcasGA2_TC011233 [Tribolium castaneum] 759067333 XM_011344833.1 251 3.09141e-126 PREDICTED: Cerapachys biroi protein ST7 homolog (LOC105282664), mRNA -- -- -- -- Q9VPB1 2095 7.3e-234 Protein ST7 homolog OS=Drosophila melanogaster GN=CG3634 PE=2 SV=1 PF13181//PF00515//PF00637//PF13174//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//Tetratricopeptide repeat//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding -- -- KOG3807 Predicted membrane protein ST7 (tumor suppressor in humans) Cluster-8309.43611 BF_2 3.00 0.47 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43614 BF_2 997.16 9.54 4660 642933926 XP_008197570.1 2887 0.0e+00 PREDICTED: protein Skeletor, isoforms B/C isoform X2 [Tribolium castaneum] 642933925 XM_008199348.1 442 0 PREDICTED: Tribolium castaneum protein Skeletor, isoforms B/C (LOC661990), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 894 2.7e-94 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.43615 BF_2 1683.93 62.29 1418 642920923 XP_008192617.1 1088 6.4e-116 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 573 1.4e-57 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.43616 BF_2 238.12 85.15 403 835482914 AKM70276.1 152 6.1e-08 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43618 BF_2 429.57 138.59 416 835482914 AKM70276.1 163 3.4e-09 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43620 BF_2 1537.95 11.04 6117 91080927 XP_974039.1 6563 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3110 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF02617//PF01599//PF04183//PF02207 ATP-dependent Clp protease adaptor protein ClpS//Ribosomal protein S27a//IucA / IucC family//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0016567//GO:0030163//GO:0042254//GO:0006826//GO:0019290 translation//protein ubiquitination//protein catabolic process//ribosome biogenesis//iron ion transport//siderophore biosynthetic process GO:0004842//GO:0003735//GO:0008270//GO:0015343 ubiquitin-protein transferase activity//structural constituent of ribosome//zinc ion binding//siderophore transmembrane transporter activity GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.43621 BF_2 10.37 0.34 1554 642928322 XP_008195533.1 577 1.3e-56 PREDICTED: transmembrane protein 50A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9CAZ8 330 2.3e-29 Transmembrane protein 50B OS=Papio anubis GN=TMEM50B PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3393 Predicted membrane protein Cluster-8309.43622 BF_2 1571.84 8.08 8427 642911986 XP_008199051.1 3925 0.0e+00 PREDICTED: uncharacterized protein LOC657912 isoform X4 [Tribolium castaneum] 642911985 XM_008200829.1 807 0 PREDICTED: Tribolium castaneum amyloid beta A4 precursor protein-binding family A member 1-like (LOC657912), transcript variant X4, mRNA K04531 APBA1, X11 amyloid beta (A4) precursor protein-binding, family A, member 1 (X11) http://www.genome.jp/dbget-bin/www_bget?ko:K04531 O17583 1393 6.7e-152 Protein lin-10 OS=Caenorhabditis elegans GN=lin-10 PE=1 SV=1 PF13180//PF05773//PF00595//PF00640//PF05743 PDZ domain//RWD domain//PDZ domain (Also known as DHR or GLGF)//Phosphotyrosine interaction domain (PTB/PID)//UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG3605 Beta amyloid precursor-binding protein Cluster-8309.43627 BF_2 31.46 1.13 1455 642926860 XP_971810.2 180 1.3e-10 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H4Z2 132 1.9e-06 Zinc finger protein 335 OS=Homo sapiens GN=ZNF335 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43631 BF_2 9.00 3.67 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF04988//PF07649 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//C1-like domain GO:0055114 oxidation-reduction process GO:0003677//GO:0047134//GO:0046872 DNA binding//protein-disulfide reductase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.43634 BF_2 437.88 4.38 4465 642924813 XP_008194051.1 3880 0.0e+00 PREDICTED: nuclear receptor coactivator 7 isoform X3 [Tribolium castaneum] 749755570 XM_011141969.1 132 8.4915e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q8NI08 710 5.6e-73 Nuclear receptor coactivator 7 OS=Homo sapiens GN=NCOA7 PE=1 SV=2 PF01092//PF00569 Ribosomal protein S6e//Zinc finger, ZZ type GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2372 Oxidation resistance protein Cluster-8309.43635 BF_2 263.72 2.02 5759 780110017 XP_011676369.1 240 5.5e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 207 1.5e-14 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF07776//PF13606//PF06213//PF01539 Ankyrin repeat//Zinc-finger associated domain (zf-AD)//Ankyrin repeat//Cobalamin biosynthesis protein CobT//Hepatitis C virus envelope glycoprotein E1 GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0019031//GO:0005634 viral envelope//nucleus KOG4177 Ankyrin Cluster-8309.43637 BF_2 22.54 0.36 2943 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43638 BF_2 401.17 1.74 9906 478255274 ENN75503.1 1875 2.5e-206 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] 815822303 XM_012377001.1 72 4.27201e-26 PREDICTED: Linepithema humile DNA primase small subunit (LOC105678028), mRNA K02684 PRI1 DNA primase small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02684 Q24317 1060 3.2e-113 DNA primase small subunit OS=Drosophila melanogaster GN=DNApol-alpha50 PE=2 SV=2 PF00057//PF13180//PF00884//PF00595//PF01896 Low-density lipoprotein receptor domain class A//PDZ domain//Sulfatase//PDZ domain (Also known as DHR or GLGF)//Eukaryotic and archaeal DNA primase small subunit GO:0006351//GO:0008152//GO:0006269 transcription, DNA-templated//metabolic process//DNA replication, synthesis of RNA primer GO:0005515//GO:0003896//GO:0008484 protein binding//DNA primase activity//sulfuric ester hydrolase activity GO:0005657//GO:0005730 replication fork//nucleolus -- -- Cluster-8309.43641 BF_2 72.19 0.49 6437 642922760 XP_008193313.1 2754 1.9e-308 PREDICTED: RNA pseudouridylate synthase domain-containing protein 2-like isoform X2 [Tribolium castaneum] 751220523 XM_011165095.1 223 3.17762e-110 PREDICTED: Solenopsis invicta RNA pseudouridylate synthase domain-containing protein 2-like (LOC105198399), transcript variant X3, mRNA -- -- -- -- Q8IZ73 1040 4.4e-111 RNA pseudouridylate synthase domain-containing protein 2 OS=Homo sapiens GN=RPUSD2 PE=1 SV=2 PF13895//PF00951//PF00849 Immunoglobulin domain//Arterivirus GL envelope glycoprotein//RNA pseudouridylate synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982//GO:0005515 RNA binding//pseudouridine synthase activity//protein binding GO:0019031 viral envelope KOG1919 RNA pseudouridylate synthases Cluster-8309.43642 BF_2 1116.44 21.01 2510 91078722 XP_967156.1 3311 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 5 [Tribolium castaneum]>gi|270004088|gb|EFA00536.1| hypothetical protein TcasGA2_TC003401 [Tribolium castaneum] 642915936 XM_962063.2 359 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 5 (LOC655510), mRNA K11836 USP5_13, UBP14 ubiquitin carboxyl-terminal hydrolase 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K11836 P56399 2135 1.8e-238 Ubiquitin carboxyl-terminal hydrolase 5 OS=Mus musculus GN=Usp5 PE=1 SV=1 PF00443//PF02148 Ubiquitin carboxyl-terminal hydrolase//Zn-finger in ubiquitin-hydrolases and other protein GO:0016579//GO:0006508//GO:0006511 protein deubiquitination//proteolysis//ubiquitin-dependent protein catabolic process GO:0046872//GO:0008234//GO:0008270//GO:0004221//GO:0008242//GO:0036459 metal ion binding//cysteine-type peptidase activity//zinc ion binding//obsolete ubiquitin thiolesterase activity//omega peptidase activity//ubiquitinyl hydrolase activity -- -- KOG0944 Ubiquitin-specific protease UBP14 Cluster-8309.43643 BF_2 38.76 0.60 2978 91078722 XP_967156.1 2751 1.9e-308 PREDICTED: ubiquitin carboxyl-terminal hydrolase 5 [Tribolium castaneum]>gi|270004088|gb|EFA00536.1| hypothetical protein TcasGA2_TC003401 [Tribolium castaneum] 642915936 XM_962063.2 344 7.96473e-178 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 5 (LOC655510), mRNA K11836 USP5_13, UBP14 ubiquitin carboxyl-terminal hydrolase 5/13 http://www.genome.jp/dbget-bin/www_bget?ko:K11836 P45974 1809 1.4e-200 Ubiquitin carboxyl-terminal hydrolase 5 OS=Homo sapiens GN=USP5 PE=1 SV=2 PF00443//PF03635//PF02845 Ubiquitin carboxyl-terminal hydrolase//Vacuolar protein sorting-associated protein 35//CUE domain GO:0006511//GO:0006508//GO:0042147//GO:0015031//GO:0016579 ubiquitin-dependent protein catabolic process//proteolysis//retrograde transport, endosome to Golgi//protein transport//protein deubiquitination GO:0036459//GO:0008242//GO:0005515//GO:0008234//GO:0008270//GO:0004221//GO:0008565//GO:0046872 ubiquitinyl hydrolase activity//omega peptidase activity//protein binding//cysteine-type peptidase activity//zinc ion binding//obsolete ubiquitin thiolesterase activity//protein transporter activity//metal ion binding GO:0030904 retromer complex KOG0944 Ubiquitin-specific protease UBP14 Cluster-8309.43644 BF_2 325.32 24.35 846 189241532 XP_969755.2 532 1.1e-51 PREDICTED: transmembrane emp24 domain-containing protein 3 [Tribolium castaneum]>gi|270001016|gb|EEZ97463.1| hypothetical protein TcasGA2_TC011294 [Tribolium castaneum] -- -- -- -- -- K14825 ERP2 protein ERP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14825 Q9Y3B3 388 2.3e-36 Transmembrane emp24 domain-containing protein 7 OS=Homo sapiens GN=TMED7 PE=1 SV=2 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG1693 emp24/gp25L/p24 family of membrane trafficking proteins Cluster-8309.43645 BF_2 468.00 30.03 939 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43646 BF_2 63.67 0.39 7098 642924674 XP_008194391.1 1323 1.8e-142 PREDICTED: protein abrupt isoform X2 [Tribolium castaneum] 642924672 XM_969854.3 316 7.02057e-162 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X4, mRNA -- -- -- -- Q24174 657 1.2e-66 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF04135//PF00096//PF13465//PF02892//PF13912//PF00651 Nucleolar RNA-binding protein, Nop10p family//Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//BTB/POZ domain GO:0042254//GO:0001522 ribosome biogenesis//pseudouridine synthesis GO:0005515//GO:0046872//GO:0030515//GO:0003677 protein binding//metal ion binding//snoRNA binding//DNA binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.43647 BF_2 145.48 0.92 6873 642924674 XP_008194391.1 1323 1.7e-142 PREDICTED: protein abrupt isoform X2 [Tribolium castaneum] 642924672 XM_969854.3 316 6.79686e-162 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X4, mRNA -- -- -- -- Q24174 657 1.2e-66 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF02892//PF13912//PF00651//PF04135//PF13465//PF00096 BED zinc finger//C2H2-type zinc finger//BTB/POZ domain//Nucleolar RNA-binding protein, Nop10p family//Zinc-finger double domain//Zinc finger, C2H2 type GO:0042254//GO:0001522 ribosome biogenesis//pseudouridine synthesis GO:0030515//GO:0003677//GO:0005515//GO:0046872 snoRNA binding//DNA binding//protein binding//metal ion binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.43649 BF_2 470.64 10.22 2214 91089979 XP_973921.1 1248 2.8e-134 PREDICTED: uncharacterized protein LOC662748 isoform X2 [Tribolium castaneum]>gi|270013543|gb|EFA09991.1| hypothetical protein TcasGA2_TC012158 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05191 Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017 adenylate kinase activity -- -- -- -- Cluster-8309.43650 BF_2 1079.91 24.24 2151 189239736 XP_001809239.1 901 4.7e-94 PREDICTED: uncharacterized protein LOC100141683 [Tribolium castaneum]>gi|270011260|gb|EFA07708.1| hypothetical protein TcasGA2_TC002185 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43651 BF_2 115.10 2.24 2437 478252725 ENN73120.1 1233 1.7e-132 hypothetical protein YQE_10261, partial [Dendroctonus ponderosae] -- -- -- -- -- K18398 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18398 Q9EQG7 420 1.3e-39 Ectonucleotide pyrophosphatase/phosphodiesterase family member 5 OS=Mus musculus GN=Enpp5 PE=2 SV=3 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase -- -- GO:0003824 catalytic activity -- -- KOG2645 Type I phosphodiesterase/nucleotide pyrophosphatase Cluster-8309.43652 BF_2 447.78 7.46 2797 478252725 ENN73120.1 1649 1.1e-180 hypothetical protein YQE_10261, partial [Dendroctonus ponderosae] -- -- -- -- -- K18398 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase family member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18398 Q0VA77 603 9.0e-61 Bis(5'-adenosyl)-triphosphatase enpp4 OS=Xenopus tropicalis GN=enpp4 PE=2 SV=1 PF01663 Type I phosphodiesterase / nucleotide pyrophosphatase -- -- GO:0003824 catalytic activity -- -- KOG2645 Type I phosphodiesterase/nucleotide pyrophosphatase Cluster-8309.43653 BF_2 21.02 1.57 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43654 BF_2 295.10 2.05 6296 642919612 XP_008191939.1 1923 4.2e-212 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X4 [Tribolium castaneum] 642919611 XM_008193717.1 100 7.37479e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 5.3e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF02257//PF01388//PF12031 RFX DNA-binding domain//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518) GO:0006355//GO:0006338 regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex -- -- Cluster-8309.43656 BF_2 234.28 1.61 6373 91087271 XP_975540.1 2035 4.4e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 7.5e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.43659 BF_2 2469.32 43.26 2675 642923832 XP_008193898.1 2379 2.4e-265 PREDICTED: importin subunit alpha-4 [Tribolium castaneum] 170029938 XM_001842796.1 313 1.22201e-160 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 1914 8.2e-213 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF01602//PF11698//PF00514//PF01749//PF10508//PF02985 Adaptin N terminal region//V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Importin beta binding domain//Proteasome non-ATPase 26S subunit//HEAT repeat GO:0015031//GO:0043248//GO:0006606//GO:0016192//GO:0015991//GO:0006886 protein transport//proteasome assembly//protein import into nucleus//vesicle-mediated transport//ATP hydrolysis coupled proton transport//intracellular protein transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0005737//GO:0000221//GO:0005634 membrane coat//cytoplasm//vacuolar proton-transporting V-type ATPase, V1 domain//nucleus KOG0166 Karyopherin (importin) alpha Cluster-8309.43663 BF_2 195.74 2.39 3717 642937806 XP_008200308.1 1035 2.3e-109 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937808|ref|XP_008200309.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937810|ref|XP_008200310.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51884 137 1.3e-06 Lumican OS=Homo sapiens GN=LUM PE=1 SV=2 PF00560//PF13855//PF13516 Leucine Rich Repeat//Leucine rich repeat//Leucine Rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.43664 BF_2 384.12 6.74 2672 642937806 XP_008200308.1 1035 1.7e-109 PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937808|ref|XP_008200309.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum]>gi|642937810|ref|XP_008200310.1| PREDICTED: leucine-rich repeat-containing protein 15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51884 137 9.3e-07 Lumican OS=Homo sapiens GN=LUM PE=1 SV=2 PF00560//PF13516//PF13855 Leucine Rich Repeat//Leucine Rich repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.43666 BF_2 473.67 4.15 5067 642911723 XP_008200714.1 359 7.8e-31 PREDICTED: scaffold attachment factor B2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YR5 202 5.1e-14 Scaffold attachment factor B2 OS=Mus musculus GN=Safb2 PE=2 SV=2 PF06459//PF09270//PF04111//PF00076//PF02932 Ryanodine Receptor TM 4-6//Beta-trefoil DNA-binding domain//Autophagy protein Apg6//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Neurotransmitter-gated ion-channel transmembrane region GO:0006914//GO:0006816//GO:0006874//GO:0006811//GO:0006355 autophagy//calcium ion transport//cellular calcium ion homeostasis//ion transport//regulation of transcription, DNA-templated GO:0005219//GO:0000978//GO:0000982//GO:0003676 ryanodine-sensitive calcium-release channel activity//RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding//nucleic acid binding GO:0016021//GO:0005634//GO:0016020//GO:0005622 integral component of membrane//nucleus//membrane//intracellular -- -- Cluster-8309.43669 BF_2 43.59 0.48 4125 820805580 AKG92781.1 3171 0.0e+00 trachealess [Leptinotarsa decemlineata] 820805579 KP147944.1 572 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1104 1.1e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF08447//PF00010//PF04551//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold GO:0016114//GO:0055114//GO:0006355 terpenoid biosynthetic process//oxidation-reduction process//regulation of transcription, DNA-templated GO:0046983//GO:0005515//GO:0046429 protein dimerization activity//protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.43670 BF_2 25.88 0.43 2825 642924692 XP_008194400.1 677 5.8e-68 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 131 4.9e-06 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF01534//PF00002//PF01857//PF00737 Frizzled/Smoothened family membrane region//7 transmembrane receptor (Secretin family)//Retinoblastoma-associated protein B domain//Photosystem II 10 kDa phosphoprotein GO:0051726//GO:0050821//GO:0015979//GO:0007186//GO:0007166 regulation of cell cycle//protein stabilization//photosynthesis//G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway GO:0004930//GO:0042301 G-protein coupled receptor activity//phosphate ion binding GO:0005634//GO:0016021//GO:0016020//GO:0009523 nucleus//integral component of membrane//membrane//photosystem II -- -- Cluster-8309.43671 BF_2 778.74 16.39 2275 642924692 XP_008194400.1 1010 1.1e-106 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 255 1.6e-20 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.43672 BF_2 2242.00 86.85 1367 91087851 XP_968461.1 1418 3.3e-154 PREDICTED: D-arabinitol dehydrogenase 1 [Tribolium castaneum]>gi|270012005|gb|EFA08453.1| hypothetical protein TcasGA2_TC006100 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R0J7 383 1.4e-35 D-arabinitol dehydrogenase 1 OS=Uromyces fabae GN=ARD1 PE=1 SV=1 PF08240//PF02558//PF00107 Alcohol dehydrogenase GroES-like domain//Ketopantoate reductase PanE/ApbA//Zinc-binding dehydrogenase GO:0015940//GO:0055114 pantothenate biosynthetic process//oxidation-reduction process GO:0008677//GO:0008270//GO:0000166//GO:0046872//GO:0016491 2-dehydropantoate 2-reductase activity//zinc ion binding//nucleotide binding//metal ion binding//oxidoreductase activity -- -- KOG0024 Sorbitol dehydrogenase Cluster-8309.43675 BF_2 163.45 1.00 7140 642939442 XP_008200393.1 3574 0.0e+00 PREDICTED: maternal protein pumilio isoform X6 [Tribolium castaneum] 642939433 XM_008202167.1 727 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.8e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF00806//PF08144 Pumilio-family RNA binding repeat//CPL (NUC119) domain -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.43676 BF_2 772.00 10.31 3419 642938912 XP_008195563.1 4292 0.0e+00 PREDICTED: valine--tRNA ligase [Tribolium castaneum]>gi|270016168|gb|EFA12616.1| hypothetical protein TcasGA2_TC006857 [Tribolium castaneum] 780637039 XM_011688674.1 185 2.23585e-89 PREDICTED: Wasmannia auropunctata valine--tRNA ligase (LOC105449436), transcript variant X2, mRNA K01873 VARS, valS valyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01873 P49696 3306 0.0e+00 Valine--tRNA ligase OS=Takifugu rubripes GN=vars PE=3 SV=1 PF13603//PF09334//PF00133//PF08264//PF10458 Leucyl-tRNA synthetase, Domain 2//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA//Valyl tRNA synthetase tRNA binding arm GO:0009098//GO:0009097//GO:0006438//GO:0006450//GO:0009099//GO:0006418 leucine biosynthetic process//isoleucine biosynthetic process//valyl-tRNA aminoacylation//regulation of translational fidelity//valine biosynthetic process//tRNA aminoacylation for protein translation GO:0005524//GO:0004812//GO:0004832//GO:0002161//GO:0000166 ATP binding//aminoacyl-tRNA ligase activity//valine-tRNA ligase activity//aminoacyl-tRNA editing activity//nucleotide binding GO:0005737 cytoplasm KOG0432 Valyl-tRNA synthetase Cluster-8309.43677 BF_2 38.92 0.52 3413 91076406 XP_969383.1 1130 2.1e-120 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 Q6AZW2 703 2.8e-72 Alcohol dehydrogenase [NADP(+)] A OS=Danio rerio GN=akr1a1a PE=2 SV=2 PF00038//PF01353//PF04728 Intermediate filament protein//Green fluorescent protein//Lipoprotein leucine-zipper GO:0008218//GO:0055114 bioluminescence//oxidation-reduction process GO:0016491//GO:0005198 oxidoreductase activity//structural molecule activity GO:0019867//GO:0005882 outer membrane//intermediate filament -- -- Cluster-8309.43679 BF_2 55.14 0.51 4784 478251175 ENN71651.1 1844 4.7e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.43680 BF_2 105.65 0.99 4773 478251175 ENN71651.1 1844 4.7e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.43681 BF_2 3.52 0.31 763 478257549 ENN77703.1 470 1.6e-44 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 166 1.1e-10 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0020037//GO:0019825 heme binding//oxygen binding -- -- -- -- Cluster-8309.43684 BF_2 20.06 0.41 2314 642931172 XP_008196469.1 1143 4.4e-122 PREDICTED: uncharacterized protein LOC658141 isoform X2 [Tribolium castaneum]>gi|270012106|gb|EFA08554.1| hypothetical protein TcasGA2_TC006209 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43685 BF_2 273.90 3.69 3394 166851820 NP_001107777.1 386 3.8e-34 pH-sensitive chloride channel precursor [Tribolium castaneum]>gi|642914731|ref|XP_008190329.1| PREDICTED: pH-sensitive chloride channel isoform X1 [Tribolium castaneum]>gi|156447623|gb|ABU63604.1| pH sensitive chloride channel [Tribolium castaneum]>gi|270002732|gb|EEZ99179.1| pHCl [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane -- -- Cluster-8309.43686 BF_2 448.18 1.98 9749 642914729 XP_008190327.1 1611 9.9e-176 PREDICTED: pH-sensitive chloride channel isoform X8 [Tribolium castaneum] 642914730 XM_008192107.1 360 0 PREDICTED: Tribolium castaneum pH sensitive chloride channel (Phcl), transcript variant X8, mRNA -- -- -- -- Q94900 458 2.0e-43 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.43687 BF_2 161.59 7.41 1200 642926449 XP_008191964.1 927 2.5e-97 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|642926451|ref|XP_008191965.1| PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009087|gb|EFA05535.1| hypothetical protein TcasGA2_TC015722 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18173 537 1.7e-53 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF05834//PF07992//PF00732//PF02254 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0006813//GO:0055114 carotenoid biosynthetic process//potassium ion transport//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.43688 BF_2 24.01 0.40 2811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43690 BF_2 1047.33 3.37 13303 642926407 XP_008191950.1 4370 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.22283e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.8e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF10541//PF00046//PF02121//PF03325//PF05920//PF03699//PF00529//PF02376 Nuclear envelope localisation domain//Homeobox domain//Phosphatidylinositol transfer protein//Herpesvirus polymerase accessory protein//Homeobox KN domain//Uncharacterised protein family (UPF0182)//HlyD membrane-fusion protein of T1SS//CUT domain GO:0019079//GO:0055085//GO:0006810//GO:0006355//GO:0006260 viral genome replication//transmembrane transport//transport//regulation of transcription, DNA-templated//DNA replication GO:0030337//GO:0003677 DNA polymerase processivity factor activity//DNA binding GO:0016021//GO:0042575//GO:0016020//GO:0005622 integral component of membrane//DNA polymerase complex//membrane//intracellular KOG3668 Phosphatidylinositol transfer protein Cluster-8309.43692 BF_2 198.92 2.30 3900 642935910 XP_008198225.1 1985 1.7e-219 PREDICTED: BMP-binding endothelial regulator protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 950 7.2e-101 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF01479//PF00093 S4 domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.43693 BF_2 94.88 0.56 7368 642911815 XP_008200755.1 3980 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.43694 BF_2 100.28 0.59 7358 642911815 XP_008200755.1 3942 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5T011 547 7.3e-54 Protein SZT2 OS=Homo sapiens GN=SZT2 PE=1 SV=3 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.43695 BF_2 299.87 10.29 1506 571330966 AHF27415.1 790 2.4e-81 putative sugar transporter 3_1 [Phaedon cochleariae]>gi|571330968|gb|AHF27416.1| putative sugar transporter 3_2 [Phaedon cochleariae] -- -- -- -- -- K08145 SLC2A8, GLUT8 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08145 P58354 307 1.0e-26 Solute carrier family 2, facilitated glucose transporter member 8 OS=Bos taurus GN=SLC2A8 PE=2 SV=2 PF01769//PF00083//PF07690 Divalent cation transporter//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006812//GO:0055085 cation transport//transmembrane transport GO:0008324//GO:0022857 cation transmembrane transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.43697 BF_2 35.21 2.14 974 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43698 BF_2 109.90 0.72 6676 642917326 XP_008199254.1 3269 0.0e+00 PREDICTED: kazrin isoform X2 [Tribolium castaneum] 642917325 XM_008201032.1 539 0 PREDICTED: Tribolium castaneum kazrin (LOC658072), transcript variant X2, mRNA -- -- -- -- Q5FWS6 736 8.1e-76 Kazrin OS=Rattus norvegicus GN=Kazn PE=2 SV=2 PF09482//PF12285//PF14010//PF00536//PF02183//PF04923//PF07647 Bacterial type III secretion apparatus protein (OrgA_MxiK)//Protein of unknown function (DUF3621)//Phosphoenolpyruvate carboxylase//SAM domain (Sterile alpha motif)//Homeobox associated leucine zipper//Ninjurin//SAM domain (Sterile alpha motif) GO:0009405//GO:0006094//GO:0006355//GO:0006099//GO:0042246//GO:0019643//GO:0015977//GO:0007155 pathogenesis//gluconeogenesis//regulation of transcription, DNA-templated//tricarboxylic acid cycle//tissue regeneration//reductive tricarboxylic acid cycle//carbon fixation//cell adhesion GO:0008964//GO:0004252//GO:0003700//GO:0043565//GO:0005515//GO:0070008 phosphoenolpyruvate carboxylase activity//serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein binding//serine-type exopeptidase activity GO:0016021//GO:0005667 integral component of membrane//transcription factor complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.43699 BF_2 92.21 0.43 9194 270006069 EFA02517.1 3290 0.0e+00 hypothetical protein TcasGA2_TC008222 [Tribolium castaneum] 170039953 XM_001847729.1 690 0 Culex quinquefasciatus conserved hypothetical protein, mRNA K04498 EP300, CREBBP, KAT3 E1A/CREB-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K04498 Q92793 2221 7.1e-248 CREB-binding protein OS=Homo sapiens GN=CREBBP PE=1 SV=3 PF09030//PF02135//PF08214//PF16987//PF02172//PF06371//PF09468//PF07711//PF12437//PF00569//PF00439 Creb binding//TAZ zinc finger//Histone acetylation protein//KIX domain//KIX domain//Diaphanous GTPase-binding Domain//Ydr279p protein family (RNase H2 complex component)//Rab geranylgeranyl transferase alpha-subunit, insert domain//Glutamine synthetase type III N terminal//Zinc finger, ZZ type//Bromodomain GO:0009252//GO:0006807//GO:0016573//GO:0042967//GO:0006355//GO:0030036 peptidoglycan biosynthetic process//nitrogen compound metabolic process//histone acetylation//acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated//actin cytoskeleton organization GO:0004356//GO:0004402//GO:0003713//GO:0005515//GO:0017048//GO:0003779//GO:0003712//GO:0008270//GO:0004663 glutamate-ammonia ligase activity//histone acetyltransferase activity//transcription coactivator activity//protein binding//Rho GTPase binding//actin binding//transcription cofactor activity//zinc ion binding//Rab geranylgeranyltransferase activity GO:0005634//GO:0005968//GO:0005667//GO:0000123 nucleus//Rab-protein geranylgeranyltransferase complex//transcription factor complex//histone acetyltransferase complex KOG1778 CREB binding protein/P300 and related TAZ Zn-finger proteins Cluster-8309.43702 BF_2 89.31 0.81 4926 91090284 XP_971237.1 1565 1.1e-170 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 500 1.4e-48 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.43703 BF_2 3297.55 33.89 4358 91090284 XP_971237.1 1631 2.1e-178 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 537 6.3e-53 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.43705 BF_2 364.65 7.31 2375 642923613 XP_008193578.1 1719 7.2e-189 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X2 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.01356e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 1323 2.5e-144 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.43706 BF_2 18.30 2.64 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43707 BF_2 87.21 0.75 5155 2654204 AAC63079.1 1031 9.4e-109 putative juvenile hormone esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01020//PF03945 Ribosomal L40e family//delta endotoxin, N-terminal domain GO:0009405//GO:0042254//GO:0006412 pathogenesis//ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.43708 BF_2 1334.38 22.84 2731 478255819 ENN76027.1 1030 6.5e-109 hypothetical protein YQE_07403, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00658//PF06305 Poly-adenylate binding protein, unique domain//Protein of unknown function (DUF1049) -- -- GO:0003723 RNA binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.43711 BF_2 4.00 5.27 304 817061123 XP_012252151.1 133 7.5e-06 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43712 BF_2 527.54 10.48 2392 642923254 XP_008193679.1 749 2.2e-76 PREDICTED: DNA repair protein XRCC3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K10880 XRCC3 DNA-repair protein XRCC3 http://www.genome.jp/dbget-bin/www_bget?ko:K10880 Q08DH8 411 1.4e-38 DNA repair protein XRCC3 OS=Bos taurus GN=XRCC3 PE=2 SV=1 PF00154//PF03796 recA bacterial DNA recombination protein//DnaB-like helicase C terminal domain GO:0006260//GO:0009432//GO:0006281 DNA replication//SOS response//DNA repair GO:0005524//GO:0003678//GO:0003697 ATP binding//DNA helicase activity//single-stranded DNA binding GO:0005657 replication fork KOG1564 DNA repair protein RHP57 Cluster-8309.43713 BF_2 60.93 1.09 2636 167234455 NP_001107843.1 1160 5.3e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.4e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43714 BF_2 354.01 1.87 8193 642918562 XP_008199292.1 1023 1.3e-107 PREDICTED: large proline-rich protein BAG6 isoform X1 [Tribolium castaneum] 242016373 XM_002428751.1 60 1.65424e-19 Pediculus humanus corporis RWD domain-containing protein, putative, mRNA -- -- -- -- A4IH17 240 3.2e-18 Large proline-rich protein bag6 OS=Xenopus tropicalis GN=Bag6 PE=2 SV=1 PF07469//PF14560//PF00240//PF05773 Domain of unknown function (DUF1518)//Ubiquitin-like domain//Ubiquitin family//RWD domain -- -- GO:0005515 protein binding GO:0005634 nucleus KOG4018 Uncharacterized conserved protein, contains RWD domain Cluster-8309.43716 BF_2 347.30 1.87 8059 642928738 XP_008199761.1 3549 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|642928740|ref|XP_008199762.1| PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|270009769|gb|EFA06217.1| hypothetical protein TcasGA2_TC009066 [Tribolium castaneum] 642928739 XM_008201540.1 59 5.85196e-19 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 4 regulatory subunit 3 (LOC663105), transcript variant X2, mRNA K17491 SMEK, PPP4R3 protein phosphatase 4 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17491 Q9VFS5 2688 4.4e-302 Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Drosophila melanogaster GN=flfl PE=1 SV=4 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG2175 Protein predicted to be involved in carbohydrate metabolism Cluster-8309.43717 BF_2 65.25 0.35 8097 642928738 XP_008199761.1 3549 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|642928740|ref|XP_008199762.1| PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|270009769|gb|EFA06217.1| hypothetical protein TcasGA2_TC009066 [Tribolium castaneum] 642928739 XM_008201540.1 59 5.87968e-19 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 4 regulatory subunit 3 (LOC663105), transcript variant X2, mRNA K17491 SMEK, PPP4R3 protein phosphatase 4 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17491 Q9VFS5 2688 4.4e-302 Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Drosophila melanogaster GN=flfl PE=1 SV=4 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG2175 Protein predicted to be involved in carbohydrate metabolism Cluster-8309.43719 BF_2 379.37 10.89 1744 546673729 ERL85285.1 1122 8.9e-120 hypothetical protein D910_02706 [Dendroctonus ponderosae] -- -- -- -- -- K10812 GlcAT-SP beta-1,3-glucuronyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10812 Q9VTG7 854 4.4e-90 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P OS=Drosophila melanogaster GN=GlcAT-P PE=2 SV=1 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.43723 BF_2 100.00 48.37 371 478255731 ENN75940.1 220 7.4e-16 hypothetical protein YQE_07475, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43726 BF_2 703.10 21.50 1655 91082187 XP_971460.1 565 3.3e-55 PREDICTED: prostaglandin E synthase 3 [Tribolium castaneum]>gi|270007441|gb|EFA03889.1| hypothetical protein TcasGA2_TC014013 [Tribolium castaneum] -- -- -- -- -- K15730 PTGES3 cytosolic prostaglandin-E synthase http://www.genome.jp/dbget-bin/www_bget?ko:K15730 Q9VH95 227 2.1e-17 Uncharacterized protein CG16817 OS=Drosophila melanogaster GN=CG16817 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.43727 BF_2 1773.45 40.21 2132 642931467 XP_966826.3 1593 2.6e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 7.6e-20 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.43729 BF_2 66.32 0.63 4706 642913546 XP_008201056.1 1646 4.2e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 2.0e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.43731 BF_2 66.77 0.59 5024 847140834 XP_012821161.1 437 6.9e-40 PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis]>gi|847140836|ref|XP_012821162.1| PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- E9QAG8 409 5.0e-38 Zinc finger protein 431 OS=Mus musculus GN=Znf431 PE=1 SV=1 PF17123//PF07776//PF00096//PF02892//PF13912//PF05485//PF16622//PF13465 RING-like zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//BED zinc finger//C2H2-type zinc finger//THAP domain//zinc-finger C2H2-type//Zinc-finger double domain -- -- GO:0046872//GO:0005515//GO:0008270//GO:0003677//GO:0003676 metal ion binding//protein binding//zinc ion binding//DNA binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.43732 BF_2 1366.05 4.96 11810 478258209 ENN78338.1 4936 0.0e+00 hypothetical protein YQE_05141, partial [Dendroctonus ponderosae] 642917861 XM_008193096.1 510 0 PREDICTED: Tribolium castaneum protein dopey-1 homolog (LOC656419), mRNA -- -- -- -- A1ZBE8 1965 4.4e-218 Protein dopey-1 homolog OS=Drosophila melanogaster GN=CG15099 PE=1 SV=1 PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0000775//GO:0005634 chromosome, centromeric region//nucleus KOG2957 Vacuolar H+-ATPase V0 sector, subunit d Cluster-8309.43733 BF_2 87.61 0.42 9009 270005301 EFA01749.1 185 2.1e-10 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 159 8.8e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01533//PF04608//PF00096//PF09728//PF05485//PF02892//PF01708 Tospovirus nucleocapsid protein//Phosphatidylglycerophosphatase A//Zinc finger, C2H2 type//Myosin-like coiled-coil protein//THAP domain//BED zinc finger//Geminivirus putative movement protein GO:0046486//GO:0046740//GO:0006629 glycerolipid metabolic process//transport of virus in host, cell to cell//lipid metabolic process GO:0003676//GO:0008962//GO:0046872//GO:0003677//GO:0019905 nucleic acid binding//phosphatidylglycerophosphatase activity//metal ion binding//DNA binding//syntaxin binding GO:0019013//GO:0016021 viral nucleocapsid//integral component of membrane -- -- Cluster-8309.43734 BF_2 8.95 0.98 671 91090364 XP_968231.1 370 5.4e-33 PREDICTED: RING finger protein 10 [Tribolium castaneum]>gi|270013409|gb|EFA09857.1| hypothetical protein TcasGA2_TC012005 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5U6 228 6.5e-18 RING finger protein 10 OS=Homo sapiens GN=RNF10 PE=1 SV=2 -- -- -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG2164 Predicted E3 ubiquitin ligase Cluster-8309.43737 BF_2 247.39 2.04 5360 642934874 XP_008197845.1 2625 1.4e-293 PREDICTED: ecdysone-induced protein 75B, isoforms C/D isoform X4 [Tribolium castaneum] 443682249 KC020244.1 254 1.547e-127 Monochamus alternatus ecdysone-induced protein 75-like protein (E75) mRNA, partial cds K08701 NR1D3 nuclear receptor subfamily 1 group D member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08701 Q08893 1308 3.1e-142 Ecdysone-inducible protein E75 OS=Manduca sexta GN=E75 PE=2 SV=2 PF00105//PF01213//PF00104//PF05805 Zinc finger, C4 type (two domains)//Adenylate cyclase associated (CAP) N terminal//Ligand-binding domain of nuclear hormone receptor//L6 membrane protein GO:0006355//GO:0043401//GO:0007010 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//cytoskeleton organization GO:0003700//GO:0008270//GO:0043565//GO:0003779 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding//actin binding GO:0005667//GO:0016021//GO:0005634 transcription factor complex//integral component of membrane//nucleus KOG4846 Nuclear receptor Cluster-8309.43739 BF_2 17.08 1.34 820 642937603 XP_008199117.1 184 2.5e-11 PREDICTED: uncharacterized protein LOC103314536 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43741 BF_2 13.31 0.31 2100 642937603 XP_008199117.1 183 8.2e-11 PREDICTED: uncharacterized protein LOC103314536 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43744 BF_2 19.00 0.98 1095 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43746 BF_2 18.00 0.34 2490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4375 BF_2 23.51 0.83 1468 642929350 XP_008195799.1 1093 1.7e-116 PREDICTED: translation initiation factor IF-2, mitochondrial [Tribolium castaneum] 769830568 XM_011632673.1 65 4.83233e-23 PREDICTED: Pogonomyrmex barbatus translation initiation factor IF-2, mitochondrial (LOC105423025), transcript variant X4, mRNA K02519 infB, MTIF2 translation initiation factor IF-2 http://www.genome.jp/dbget-bin/www_bget?ko:K02519 P46198 686 1.1e-70 Translation initiation factor IF-2, mitochondrial OS=Bos taurus GN=MTIF2 PE=1 SV=1 PF08477//PF03193//PF01926//PF00025//PF02421//PF00071//PF10662 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ferrous iron transport protein B//Ras family//Ethanolamine utilisation - propanediol utilisation GO:0006576//GO:0007264//GO:0015684 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005524//GO:0015093//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//GTP binding GO:0016021 integral component of membrane KOG1145 Mitochondrial translation initiation factor 2 (IF-2; GTPase) Cluster-8309.43752 BF_2 180.05 0.49 15750 546679672 ERL90099.1 6770 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 3978 0.0e+00 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF00515//PF13374//PF14604//PF00018//PF08141//PF00462//PF13176//PF13414//PF13181//PF00389//PF03493//PF02826//PF03446 Tetratricopeptide repeat//Tetratricopeptide repeat//Variant SH3 domain//SH3 domain//Small acid-soluble spore protein H family//Glutaredoxin//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006813//GO:0008152//GO:0006098//GO:0045454//GO:0055114//GO:0006118//GO:0030436//GO:0019521 potassium ion transport//metabolic process//pentose-phosphate shunt//cell redox homeostasis//oxidation-reduction process//obsolete electron transport//asexual sporulation//D-gluconate metabolic process GO:0051287//GO:0005515//GO:0009055//GO:0015035//GO:0016616//GO:0015269//GO:0004616 NAD binding//protein binding//electron carrier activity//protein disulfide oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//calcium-activated potassium channel activity//phosphogluconate dehydrogenase (decarboxylating) activity GO:0016020//GO:0042601 membrane//endospore-forming forespore KOG1998 Signaling protein DOCK180 Cluster-8309.43753 BF_2 403.57 1.19 14507 546679672 ERL90099.1 6770 0.0e+00 hypothetical protein D910_07453 [Dendroctonus ponderosae] 642934911 XM_967148.3 629 0 PREDICTED: Tribolium castaneum C-terminal-binding protein (LOC660954), transcript variant X2, mRNA K13708 DOCK1 dedicator of cytokinesis protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13708 Q8BUR4 3978 0.0e+00 Dedicator of cytokinesis protein 1 OS=Mus musculus GN=Dock1 PE=1 SV=3 PF00515//PF13374//PF08141//PF00018//PF14604//PF13176//PF00462//PF13414//PF13181//PF00389//PF03493//PF02826//PF03446 Tetratricopeptide repeat//Tetratricopeptide repeat//Small acid-soluble spore protein H family//SH3 domain//Variant SH3 domain//Tetratricopeptide repeat//Glutaredoxin//TPR repeat//Tetratricopeptide repeat//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//Calcium-activated BK potassium channel alpha subunit//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0055114//GO:0019521//GO:0030436//GO:0006118//GO:0045454//GO:0006813//GO:0008152//GO:0006098 oxidation-reduction process//D-gluconate metabolic process//asexual sporulation//obsolete electron transport//cell redox homeostasis//potassium ion transport//metabolic process//pentose-phosphate shunt GO:0004616//GO:0015269//GO:0016616//GO:0015035//GO:0009055//GO:0005515//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//calcium-activated potassium channel activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//protein disulfide oxidoreductase activity//electron carrier activity//protein binding//NAD binding GO:0042601//GO:0016020 endospore-forming forespore//membrane KOG1998 Signaling protein DOCK180 Cluster-8309.43754 BF_2 679.00 62.59 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43755 BF_2 263.72 3.58 3372 546678030 ERL88754.1 994 1.2e-104 hypothetical protein D910_06136 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5NVC7 440 8.6e-42 E3 ubiquitin-protein ligase RNF34 OS=Pongo abelii GN=RNF34 PE=2 SV=2 PF15323//PF14634//PF12906//PF13639 Developmental protein//zinc-RING finger domain//RING-variant domain//Ring finger domain GO:0048598 embryonic morphogenesis GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0072669 tRNA-splicing ligase complex -- -- Cluster-8309.43758 BF_2 129.20 2.16 2788 642933410 XP_008197405.1 2321 1.3e-258 PREDICTED: sodium-independent sulfate anion transporter isoform X2 [Tribolium castaneum] 644991717 XM_001603675.3 264 2.20766e-133 PREDICTED: Nasonia vitripennis sodium-independent sulfate anion transporter (LOC100120043), mRNA K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 959 4.7e-102 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.43759 BF_2 179.75 4.87 1832 91089905 XP_972496.1 1215 1.5e-130 PREDICTED: UDP-glucuronosyltransferase [Tribolium castaneum]>gi|270013659|gb|EFA10107.1| hypothetical protein TcasGA2_TC012286 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 577 6.1e-58 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758//GO:0016740 transferase activity, transferring hexosyl groups//transferase activity -- -- -- -- Cluster-8309.43760 BF_2 41.22 0.49 3786 270014262 EFA10710.1 1560 3.2e-170 domino [Tribolium castaneum] 760445496 XM_011401515.1 99 1.58968e-41 Auxenochlorella protothecoides Helicase swr1 partial mRNA K11661 SRCAP helicase SRCAP http://www.genome.jp/dbget-bin/www_bget?ko:K11661 Q9NDJ2 667 4.6e-68 Helicase domino OS=Drosophila melanogaster GN=dom PE=1 SV=2 PF00154//PF05625//PF00004//PF03796//PF01637//PF07088//PF00176 recA bacterial DNA recombination protein//PAXNEB protein//ATPase family associated with various cellular activities (AAA)//DnaB-like helicase C terminal domain//Archaeal ATPase//GvpD gas vesicle protein//SNF2 family N-terminal domain GO:0006260//GO:0009432//GO:0006281 DNA replication//SOS response//DNA repair GO:0003697//GO:0003678//GO:0005524 single-stranded DNA binding//DNA helicase activity//ATP binding GO:0033588//GO:0005657 Elongator holoenzyme complex//replication fork KOG0391 SNF2 family DNA-dependent ATPase Cluster-8309.43762 BF_2 121.43 1.07 5017 546684675 ERL94292.1 1147 3.2e-122 hypothetical protein D910_11573 [Dendroctonus ponderosae] -- -- -- -- -- K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 Q9U1N0 962 3.8e-102 Hrp65 protein OS=Chironomus tentans GN=HRP65 PE=1 SV=1 PF02601//PF00076 Exonuclease VII, large subunit//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006308 DNA catabolic process GO:0003676//GO:0008855 nucleic acid binding//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG0115 RNA-binding protein p54nrb (RRM superfamily) Cluster-8309.43765 BF_2 327.87 3.67 4021 642926686 XP_008194968.1 2027 2.4e-224 PREDICTED: optomotor-blind protein [Tribolium castaneum] 815905935 XM_012383383.1 239 2.52427e-119 PREDICTED: Bombus impatiens optomotor-blind protein (LOC100740497), partial mRNA K10177 TBX3 T-box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10177 Q24432 1212 3.1e-131 Optomotor-blind protein OS=Drosophila melanogaster GN=bi PE=1 SV=3 PF06624//PF00907 Ribosome associated membrane protein RAMP4//T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667//GO:0005783 nucleus//transcription factor complex//endoplasmic reticulum KOG3585 TBX2 and related T-box transcription factors Cluster-8309.43766 BF_2 96.56 1.69 2679 189240077 XP_971167.2 1503 9.1e-164 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 190 6.7e-13 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.43767 BF_2 28.87 0.45 2997 270009512 EFA05960.1 1136 3.7e-121 hypothetical protein TcasGA2_TC008778 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P07686 869 1.4e-91 Beta-hexosaminidase subunit beta OS=Homo sapiens GN=HEXB PE=1 SV=3 PF08085//PF09328//PF08013//PF00728 Entericidin EcnA/B family//Domain of unknown function (DUF1984)//Tagatose 6 phosphate kinase//Glycosyl hydrolase family 20, catalytic domain GO:0046938//GO:0005975//GO:0009636//GO:0019402//GO:0010038 phytochelatin biosynthetic process//carbohydrate metabolic process//response to toxic substance//galactitol metabolic process//response to metal ion GO:0046872//GO:0004553//GO:0016756 metal ion binding//hydrolase activity, hydrolyzing O-glycosyl compounds//glutathione gamma-glutamylcysteinyltransferase activity GO:0016020 membrane KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.43770 BF_2 1132.58 5.13 9519 642911194 XP_008199555.1 11434 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X2 [Tribolium castaneum] 805816093 XM_012293284.1 544 0 PREDICTED: Megachile rotundata inositol 1,4,5-trisphosphate receptor (LOC100879087), transcript variant X3, mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 8769 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF00520//PF01365//PF02815 Ion transport protein//RIH domain//MIR domain GO:0006816//GO:0055085//GO:0006811//GO:0070588 calcium ion transport//transmembrane transport//ion transport//calcium ion transmembrane transport GO:0005216//GO:0005262 ion channel activity//calcium channel activity GO:0016020 membrane KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.43773 BF_2 114.27 1.22 4208 190702371 ACE75264.1 1541 5.6e-168 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00751//PF03175 DM DNA binding domain//DNA polymerase type B, organellar and viral GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008408//GO:0043565//GO:0000166//GO:0003677//GO:0003887 3'-5' exonuclease activity//sequence-specific DNA binding//nucleotide binding//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.43774 BF_2 36.51 0.95 1895 642915433 XP_008190613.1 467 8.7e-44 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00328//PF13508//PF00583//PF08445//PF13673//PF13302 Histidine phosphatase superfamily (branch 2)//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain GO:0019497//GO:0042967//GO:0006771 hexachlorocyclohexane metabolic process//acyl-carrier-protein biosynthetic process//riboflavin metabolic process GO:0016747//GO:0008080//GO:0003993 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//acid phosphatase activity -- -- -- -- Cluster-8309.43778 BF_2 2398.57 13.08 7960 189238786 XP_974651.2 2965 0.0e+00 PREDICTED: putative RNA-binding protein 15B [Tribolium castaneum] 662187094 XM_008487201.1 150 1.49723e-69 PREDICTED: Diaphorina citri putative RNA-binding protein 15 (LOC103522090), mRNA K13190 RBM15 RNA-binding protein 15 http://www.genome.jp/dbget-bin/www_bget?ko:K13190 Q96T37 714 3.4e-73 Putative RNA-binding protein 15 OS=Homo sapiens GN=RBM15 PE=1 SV=2 PF00558//PF00076//PF16367//PF00789//PF02313//PF08777//PF15281 Vpu protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//UBX domain//Fumarate reductase subunit D//RNA binding motif//Consortin C-terminus GO:0006812//GO:0032801//GO:0006106//GO:0042998//GO:0019076 cation transport//receptor catabolic process//fumarate metabolic process//positive regulation of Golgi to plasma membrane protein transport//viral release from host cell GO:0003676//GO:0003723//GO:0005261//GO:0005515//GO:0071253 nucleic acid binding//RNA binding//cation channel activity//protein binding//connexin binding GO:0016020//GO:0033644//GO:0005802 membrane//host cell membrane//trans-Golgi network KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.43779 BF_2 1372.43 7.41 8039 189238786 XP_974651.2 2965 0.0e+00 PREDICTED: putative RNA-binding protein 15B [Tribolium castaneum] 662187094 XM_008487201.1 150 1.51215e-69 PREDICTED: Diaphorina citri putative RNA-binding protein 15 (LOC103522090), mRNA K13190 RBM15 RNA-binding protein 15 http://www.genome.jp/dbget-bin/www_bget?ko:K13190 Q96T37 714 3.5e-73 Putative RNA-binding protein 15 OS=Homo sapiens GN=RBM15 PE=1 SV=2 PF15281//PF00789//PF08777//PF02313//PF00076//PF00558//PF16367 Consortin C-terminus//UBX domain//RNA binding motif//Fumarate reductase subunit D//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Vpu protein//RNA recognition motif GO:0019076//GO:0042998//GO:0006812//GO:0032801//GO:0006106 viral release from host cell//positive regulation of Golgi to plasma membrane protein transport//cation transport//receptor catabolic process//fumarate metabolic process GO:0003723//GO:0005515//GO:0071253//GO:0005261//GO:0003676 RNA binding//protein binding//connexin binding//cation channel activity//nucleic acid binding GO:0005802//GO:0016020//GO:0033644 trans-Golgi network//membrane//host cell membrane KOG2699 Predicted ubiquitin regulatory protein Cluster-8309.43780 BF_2 9.99 0.37 1418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43781 BF_2 21.00 1.31 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43785 BF_2 36.37 0.73 2385 642927926 XP_001814448.2 1898 1.3e-209 PREDICTED: LOW QUALITY PROTEIN: membralin [Tribolium castaneum] 642927925 XM_001814396.2 309 1.82023e-158 PREDICTED: Tribolium castaneum membralin (LOC663408), mRNA -- -- -- -- Q4ZIN3 1161 1.5e-125 Membralin OS=Homo sapiens GN=TMEM259 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2092 Uncharacterized conserved protein Cluster-8309.43787 BF_2 109.74 0.82 5889 642911463 XP_008199434.1 996 1.2e-104 PREDICTED: MAP7 domain-containing protein 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF03323//PF15220 MAP7 (E-MAP-115) family//Bacillus/Clostridium GerA spore germination protein//Hypoxia-inducible lipid droplet-associated GO:0001819//GO:0000226//GO:0010884//GO:0008284//GO:0009847 positive regulation of cytokine production//microtubule cytoskeleton organization//positive regulation of lipid storage//positive regulation of cell proliferation//spore germination -- -- GO:0015630//GO:0016021 microtubule cytoskeleton//integral component of membrane -- -- Cluster-8309.43788 BF_2 959.74 10.73 4030 478260571 ENN80274.1 706 3.6e-71 hypothetical protein YQE_03268, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05672//PF15220//PF03323 MAP7 (E-MAP-115) family//Hypoxia-inducible lipid droplet-associated//Bacillus/Clostridium GerA spore germination protein GO:0009847//GO:0008284//GO:0010884//GO:0000226//GO:0001819 spore germination//positive regulation of cell proliferation//positive regulation of lipid storage//microtubule cytoskeleton organization//positive regulation of cytokine production -- -- GO:0016021//GO:0015630 integral component of membrane//microtubule cytoskeleton -- -- Cluster-8309.43789 BF_2 711.59 73.89 690 322793851 EFZ17191.1 257 7.1e-20 hypothetical protein SINV_15085, partial [Solenopsis invicta] 808119683 XM_012307943.1 60 1.33179e-20 PREDICTED: Bombus terrestris 40S ribosomal protein S28 (LOC105665663), mRNA K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 Q9W334 233 1.8e-18 40S ribosomal protein S28 OS=Drosophila melanogaster GN=RpS28b PE=1 SV=2 PF01176//PF01200//PF03367 Translation initiation factor 1A / IF-1//Ribosomal protein S28e//ZPR1 zinc-finger domain GO:0042254//GO:0006413//GO:0006446//GO:0006412 ribosome biogenesis//translational initiation//regulation of translational initiation//translation GO:0008270//GO:0003735//GO:0003723//GO:0003743 zinc ion binding//structural constituent of ribosome//RNA binding//translation initiation factor activity GO:0005840//GO:0005622 ribosome//intracellular KOG3502 40S ribosomal protein S28 Cluster-8309.43790 BF_2 551.61 7.40 3404 91084021 XP_975350.1 2531 7.2e-283 PREDICTED: probable ATP-dependent RNA helicase DDX23 [Tribolium castaneum]>gi|270008001|gb|EFA04449.1| hypothetical protein TcasGA2_TC014753 [Tribolium castaneum] 571571862 XM_006564848.1 565 0 PREDICTED: Apis mellifera uncharacterized LOC551823 (LOC551823), mRNA K12858 DDX23, PRP28 ATP-dependent RNA helicase DDX23/PRP28 http://www.genome.jp/dbget-bin/www_bget?ko:K12858 Q9BUQ8 2115 5.1e-236 Probable ATP-dependent RNA helicase DDX23 OS=Homo sapiens GN=DDX23 PE=1 SV=3 PF00270//PF06862//PF00176//PF04851 DEAD/DEAH box helicase//Utp25, U3 small nucleolar RNA-associated SSU processome protein 25//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0016787//GO:0003677//GO:0003676//GO:0008026 ATP binding//hydrolase activity//DNA binding//nucleic acid binding//ATP-dependent helicase activity GO:0005634 nucleus KOG0333 U5 snRNP-like RNA helicase subunit Cluster-8309.43791 BF_2 285.60 1.86 6707 642920095 XP_008192202.1 1742 4.4e-191 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 7.42662e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.0e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43793 BF_2 110.81 0.68 7132 332372760 AEE61522.1 509 4.4e-48 unknown [Dendroctonus ponderosae]>gi|478251664|gb|ENN72118.1| hypothetical protein YQE_11177, partial [Dendroctonus ponderosae]>gi|478262743|gb|ENN81274.1| hypothetical protein YQE_02310, partial [Dendroctonus ponderosae]>gi|546680918|gb|ERL91092.1| hypothetical protein D910_08434 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P38718 366 6.9e-33 Mitochondrial pyruvate carrier 2 OS=Rattus norvegicus GN=Mpc2 PE=2 SV=1 PF03650//PF02790 Uncharacterised protein family (UPF0041)//Cytochrome C oxidase subunit II, transmembrane domain GO:0022900//GO:0006850 electron transport chain//mitochondrial pyruvate transport -- -- GO:0005743//GO:0016021 mitochondrial inner membrane//integral component of membrane KOG1589 Uncharacterized conserved protein Cluster-8309.43795 BF_2 75.01 0.46 7048 642927085 XP_008195131.1 4729 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X2 [Tribolium castaneum] 642927084 XM_008196909.1 374 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X2, mRNA -- -- -- -- A6H603 309 2.8e-26 NACHT domain- and WD repeat-containing protein 1 OS=Mus musculus GN=Nwd1 PE=2 SV=2 PF07728//PF00004//PF03193//PF00005//PF00400//PF04851//PF01637//PF00931//PF00910 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//WD domain, G-beta repeat//Type III restriction enzyme, res subunit//Archaeal ATPase//NB-ARC domain//RNA helicase -- -- GO:0016887//GO:0005525//GO:0003724//GO:0003677//GO:0016787//GO:0005524//GO:0003723//GO:0005515//GO:0003924//GO:0043531 ATPase activity//GTP binding//RNA helicase activity//DNA binding//hydrolase activity//ATP binding//RNA binding//protein binding//GTPase activity//ADP binding -- -- -- -- Cluster-8309.43796 BF_2 308.74 1.86 7216 642912703 XP_008200968.1 4488 0.0e+00 PREDICTED: cytoskeleton-associated protein 5 [Tribolium castaneum]>gi|270002915|gb|EEZ99362.1| mini spindles [Tribolium castaneum] 642912702 XM_008202746.1 130 1.77992e-58 PREDICTED: Tribolium castaneum cytoskeleton-associated protein 5 (LOC659068), mRNA K16803 CKAP5, XMAP215 cytoskeleton-associated protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K16803 Q14008 1971 5.4e-219 Cytoskeleton-associated protein 5 OS=Homo sapiens GN=CKAP5 PE=1 SV=3 PF02985//PF11640//PF12422//PF08465 HEAT repeat//Telomere-length maintenance and DNA damage repair//Condensin II non structural maintenance of chromosomes subunit//Thymidine kinase from Herpesvirus C-terminal GO:0006206//GO:0016310//GO:0009069//GO:0006230 pyrimidine nucleobase metabolic process//phosphorylation//serine family amino acid metabolic process//TMP biosynthetic process GO:0004674//GO:0005515//GO:0004797//GO:0005524 protein serine/threonine kinase activity//protein binding//thymidine kinase activity//ATP binding GO:0005634 nucleus KOG1820 Microtubule-associated protein Cluster-8309.43797 BF_2 43.56 0.36 5298 642934118 XP_008199283.1 1895 6.3e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1299 3.3e-141 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006865//GO:0055085//GO:0003333//GO:0006810 amino acid transport//transmembrane transport//amino acid transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.43800 BF_2 688.42 3.16 9387 546684330 ERL94035.1 3979 0.0e+00 hypothetical protein D910_11318 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O94812 756 5.5e-78 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF02947//PF00168//PF08392//PF01688 flt3 ligand//C2 domain//FAE1/Type III polyketide synthase-like protein//Alphaherpesvirus glycoprotein I GO:0007165//GO:0006633 signal transduction//fatty acid biosynthetic process GO:0016747//GO:0005515//GO:0005125 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//cytokine activity GO:0043657//GO:0016020 host cell//membrane KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.43803 BF_2 595.98 6.24 4281 642932431 XP_008197110.1 2076 5.2e-230 PREDICTED: uncharacterized protein LOC100141760 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43804 BF_2 160.00 1.28 5511 642915654 XP_008190698.1 870 4.7e-90 PREDICTED: uncharacterized protein LOC103312268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05745//PF03153//PF04103 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA)//Transcription factor IIA, alpha/beta subunit//CD20-like family GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0019867//GO:0005672//GO:0016021 outer membrane//transcription factor TFIIA complex//integral component of membrane -- -- Cluster-8309.43806 BF_2 1810.70 36.14 2383 91092788 XP_974007.1 919 4.2e-96 PREDICTED: dual specificity protein phosphatase 10 [Tribolium castaneum]>gi|270014786|gb|EFA11234.1| hypothetical protein TcasGA2_TC010766 [Tribolium castaneum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q0IID7 428 1.5e-40 Dual specificity protein phosphatase 10 OS=Bos taurus GN=DUSP10 PE=2 SV=1 PF05706//PF00102//PF04179//PF00782 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Initiator tRNA phosphoribosyl transferase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470//GO:0019988//GO:0035335 tyrosine metabolic process//protein dephosphorylation//charged-tRNA amino acid modification//peptidyl-tyrosine dephosphorylation GO:0043399//GO:0017017//GO:0004725//GO:0008138//GO:0004721 tRNA A64-2'-O-ribosylphosphate transferase activity//MAP kinase tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//phosphoprotein phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-8309.43807 BF_2 122.02 0.88 6113 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06449 Mitochondrial domain of unknown function (DUF1082) -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0005739//GO:0016021 mitochondrion//integral component of membrane -- -- Cluster-8309.43808 BF_2 136.40 1.37 4453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43813 BF_2 316.22 1.94 7105 795018288 XP_011859156.1 2928 0.0e+00 PREDICTED: uncharacterized protein K02A2.6-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- P0CT37 925 1.0e-97 Transposon Tf2-4 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-4 PE=3 SV=1 PF13683//PF02035//PF00665//PF00098//PF17068 Integrase core domain//Coagulin//Integrase core domain//Zinc knuckle//Required for respiratory growth protein 8 mitochondrial GO:0000002//GO:0042381//GO:0015074 mitochondrial genome maintenance//hemolymph coagulation//DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005576 extracellular region -- -- Cluster-8309.43815 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43816 BF_2 63.36 1.82 1745 642939092 XP_008200218.1 530 4.0e-51 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06209 Cofactor of BRCA1 (COBRA1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.43817 BF_2 16.53 0.41 1970 642939092 XP_008200218.1 686 3.6e-69 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606//PF06209 Ankyrin repeat//Ankyrin repeat//Cofactor of BRCA1 (COBRA1) GO:0045892 negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.43818 BF_2 105.30 2.47 2074 642939092 XP_008200218.1 955 2.5e-100 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFX9 186 1.5e-12 Tankyrase-1 OS=Mus musculus GN=Tnks PE=1 SV=1 PF06209//PF13606//PF00023 Cofactor of BRCA1 (COBRA1)//Ankyrin repeat//Ankyrin repeat GO:0045892 negative regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.43819 BF_2 2.00 1.15 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43820 BF_2 519.52 11.36 2201 189242426 XP_969950.2 1190 1.5e-127 PREDICTED: ankyrin repeat domain-containing protein 12 isoform X3 [Tribolium castaneum] 642939093 XM_964857.3 235 2.29662e-117 PREDICTED: Tribolium castaneum ankyrin repeat domain-containing protein 11 (LOC658469), transcript variant X3, mRNA -- -- -- -- Q6UB98 509 5.6e-50 Ankyrin repeat domain-containing protein 12 OS=Homo sapiens GN=ANKRD12 PE=1 SV=3 PF01405 Photosystem II reaction centre T protein GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.43823 BF_2 10.00 0.36 1463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43824 BF_2 153.43 5.01 1568 668451731 KFB40787.1 242 8.8e-18 hypothetical protein ZHAS_00008218 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- O95271 233 4.0e-18 Tankyrase-1 OS=Homo sapiens GN=TNKS PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43826 BF_2 784.57 25.06 1597 642939092 XP_008200218.1 530 3.6e-51 PREDICTED: ankyrin repeat domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06209 Cofactor of BRCA1 (COBRA1) GO:0045892 negative regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.43829 BF_2 552.16 6.72 3723 546676181 ERL87248.1 2487 1.0e-277 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9I9 673 9.1e-69 Mycosubtilin synthase subunit C OS=Bacillus subtilis GN=mycC PE=3 SV=1 PF02733//PF00501 Dak1 domain//AMP-binding enzyme GO:0046486//GO:0006071//GO:0008152 glycerolipid metabolic process//glycerol metabolic process//metabolic process GO:0004371//GO:0003824 glycerone kinase activity//catalytic activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.43830 BF_2 26.68 0.31 3836 259013492 NP_001158490.1 1405 3.0e-152 casein kinase 1, alpha 1 [Saccoglossus kowalevskii]>gi|197734685|gb|ACH73238.1| casein kinase 1 protein catalytic subunit [Saccoglossus kowalevskii] 768410303 XM_011559102.1 355 0 PREDICTED: Plutella xylostella casein kinase I isoform alpha-like (LOC105388216), transcript variant X2, mRNA K08957 CSNK1A casein kinase 1, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08957 Q8BK63 1401 3.6e-153 Casein kinase I isoform alpha OS=Mus musculus GN=Csnk1a1 PE=1 SV=2 PF05445//PF07714//PF00069 Poxvirus serine/threonine protein kinase//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004674//GO:0004672//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.43831 BF_2 834.27 10.31 3672 270014366 EFA10814.1 2201 1.4e-244 hypothetical protein TcasGA2_TC030632 [Tribolium castaneum] -- -- -- -- -- K09189 MLL5 histone-lysine N-methyltransferase MLL5 http://www.genome.jp/dbget-bin/www_bget?ko:K09189 Q3UG20 509 9.3e-50 Histone-lysine N-methyltransferase 2E OS=Mus musculus GN=Kmt2e PE=1 SV=2 PF00856//PF00569//PF00628//PF01033//PF07496 SET domain//Zinc finger, ZZ type//PHD-finger//Somatomedin B domain//CW-type Zinc Finger GO:0007165//GO:0006955 signal transduction//immune response GO:0005515//GO:0008270//GO:0005044//GO:0030247 protein binding//zinc ion binding//scavenger receptor activity//polysaccharide binding -- -- KOG1844 PHD Zn-finger proteins Cluster-8309.43832 BF_2 406.70 20.73 1108 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43833 BF_2 567.00 5.33 4737 189235385 XP_969534.2 4402 0.0e+00 PREDICTED: regulator of nonsense transcripts 2 [Tribolium castaneum] -- -- -- -- -- K14327 UPF2, RENT2 regulator of nonsense transcripts 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14327 Q9HAU5 2203 4.5e-246 Regulator of nonsense transcripts 2 OS=Homo sapiens GN=UPF2 PE=1 SV=1 PF02854 MIF4G domain -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG2051 Nonsense-mediated mRNA decay 2 protein Cluster-8309.43835 BF_2 172.00 2.45 3227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43836 BF_2 5.00 0.46 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43837 BF_2 2068.61 36.27 2673 531445261 AGT57839.1 756 3.8e-77 cytochrome P450 12h2, partial [Leptinotarsa decemlineata] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 547 2.7e-54 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.43839 BF_2 902.79 6.36 6226 270003174 EEZ99621.1 1609 1.1e-175 hypothetical protein TcasGA2_TC002139 [Tribolium castaneum] 817079739 XM_012406879.1 41 4.58132e-09 PREDICTED: Athalia rosae thioredoxin-related transmembrane protein 1-like (LOC105689684), mRNA K14832 MAK21, NOC1, CEBPZ ribosome biogenesis protein MAK21 http://www.genome.jp/dbget-bin/www_bget?ko:K14832 Q03701 977 8.5e-104 CCAAT/enhancer-binding protein zeta OS=Homo sapiens GN=CEBPZ PE=1 SV=3 PF00085 Thioredoxin GO:0045454 cell redox homeostasis -- -- -- -- KOG2038 CAATT-binding transcription factor/60S ribosomal subunit biogenesis protein Cluster-8309.43841 BF_2 117.68 1.60 3357 546676387 ERL87409.1 794 1.9e-81 hypothetical protein D910_04804 [Dendroctonus ponderosae] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 578 8.5e-58 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF01370//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.43842 BF_2 600.49 3.98 6605 270014159 EFA10607.1 893 1.2e-92 hypothetical protein TcasGA2_TC012868 [Tribolium castaneum] 642936629 XM_008200293.1 231 1.16461e-114 PREDICTED: Tribolium castaneum serine-arginine protein 55-like (LOC660636), mRNA K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 732 2.3e-75 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF04179//PF08777//PF00102//PF00782//PF01529//PF02868//PF01416//PF16367//PF00076 Initiator tRNA phosphoribosyl transferase//RNA binding motif//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain//DHHC palmitoyltransferase//Thermolysin metallopeptidase, alpha-helical domain//tRNA pseudouridine synthase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0001522//GO:0009451//GO:0019988//GO:0006570//GO:0006470 pseudouridine synthesis//RNA modification//charged-tRNA amino acid modification//tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0009982//GO:0003676//GO:0004725//GO:0008138//GO:0004222//GO:0003723//GO:0043399 zinc ion binding//pseudouridine synthase activity//nucleic acid binding//protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//metalloendopeptidase activity//RNA binding//tRNA A64-2'-O-ribosylphosphate transferase activity -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.43844 BF_2 247.72 1.68 6446 91076790 XP_974060.1 1407 3.0e-152 PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|642913035|ref|XP_008201360.1| PREDICTED: apoptotic protease-activating factor 1 [Tribolium castaneum]>gi|270001925|gb|EEZ98372.1| hypothetical protein TcasGA2_TC000831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O88879 532 3.5e-52 Apoptotic protease-activating factor 1 OS=Mus musculus GN=Apaf1 PE=1 SV=3 PF00931//PF00619//PF07569//PF00400 NB-ARC domain//Caspase recruitment domain//TUP1-like enhancer of split//WD domain, G-beta repeat GO:0042981//GO:0006355 regulation of apoptotic process//regulation of transcription, DNA-templated GO:0005515//GO:0043531 protein binding//ADP binding GO:0005634 nucleus -- -- Cluster-8309.43848 BF_2 916.81 18.55 2355 189238127 XP_001814833.1 1517 1.9e-165 PREDICTED: lachesin [Tribolium castaneum]>gi|270008732|gb|EFA05180.1| hypothetical protein TcasGA2_TC015310 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 1312 4.6e-143 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43849 BF_2 1018.42 18.73 2562 189238127 XP_001814833.1 1411 4.0e-153 PREDICTED: lachesin [Tribolium castaneum]>gi|270008732|gb|EFA05180.1| hypothetical protein TcasGA2_TC015310 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 1248 1.3e-135 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43850 BF_2 556.77 10.53 2500 189238127 XP_001814833.1 933 1.1e-97 PREDICTED: lachesin [Tribolium castaneum]>gi|270008732|gb|EFA05180.1| hypothetical protein TcasGA2_TC015310 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26474 809 1.0e-84 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895//PF04369 Immunoglobulin domain//Lactococcin-like family GO:0042742 defense response to bacterium GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.43852 BF_2 990.51 14.08 3229 157125048 XP_001660595.1 2233 2.5e-248 AAEL010063-PA [Aedes aegypti]>gi|108873778|gb|EAT38003.1| AAEL010063-PA [Aedes aegypti] 124487747 EF091969.1 234 1.21728e-116 Maconellicoccus hirsutus clone WHMH3794 putative T-complex protein 1 subunit gamma mRNA, partial cds K09495 CCT3, TRIC5 T-complex protein 1 subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K09495 P48605 2177 3.1e-243 T-complex protein 1 subunit gamma OS=Drosophila melanogaster GN=Cctgamma PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family GO:0006457 protein folding GO:0005524//GO:0051082 ATP binding//unfolded protein binding GO:0005737 cytoplasm KOG0364 Chaperonin complex component, TCP-1 gamma subunit (CCT3) Cluster-8309.43854 BF_2 222.67 7.36 1553 646714773 KDR18627.1 221 2.4e-15 hypothetical protein L798_06607 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43859 BF_2 2255.56 17.09 5808 642917952 XP_008198956.1 1655 4.7e-181 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 728 6.0e-75 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.4386 BF_2 8.00 1.10 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43860 BF_2 23.27 3.04 607 546675135 ERL86379.1 330 2.1e-28 hypothetical protein D910_03787, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43862 BF_2 67.44 0.75 4071 642930006 XP_008196062.1 305 1.1e-24 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 1.2e-18 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43863 BF_2 463.08 6.13 3449 91086943 XP_972716.1 828 2.2e-85 PREDICTED: G patch domain-containing protein 4 [Tribolium castaneum]>gi|270010496|gb|EFA06944.1| hypothetical protein TcasGA2_TC009895 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 437 2.0e-41 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 PF08188//PF01585 Spermatozal protamine family//G-patch domain GO:0035092 sperm chromatin condensation GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0000228 nuclear chromosome KOG1212 Amidases Cluster-8309.43865 BF_2 159.59 0.60 11389 642920053 XP_008192184.1 1927 2.6e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.85285e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.8e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF00341//PF13673//PF00159//PF02297//PF08159//PF03822//PF08445//PF00583//PF13508 PDGF/VEGF domain//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide//Cytochrome oxidase c subunit VIb//NUC153 domain//NAF domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0015992//GO:0006123//GO:0007165//GO:0042967//GO:0040007//GO:0008283 proton transport//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//acyl-carrier-protein biosynthetic process//growth//cell proliferation GO:0016747//GO:0004129//GO:0008083//GO:0008080//GO:0005179 transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity//growth factor activity//N-acetyltransferase activity//hormone activity GO:0005739//GO:0016020//GO:0005576//GO:0005634//GO:0045277 mitochondrion//membrane//extracellular region//nucleus//respiratory chain complex IV KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.43866 BF_2 92.59 1.35 3165 478254712 ENN74953.1 1280 7.7e-138 hypothetical protein YQE_08530, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 1251 7.3e-136 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF00722//PF15886 Glycosyl hydrolases family 16//Carbohydrate binding domain (family 32) GO:0005975 carbohydrate metabolic process GO:0004553//GO:0030246 hydrolase activity, hydrolyzing O-glycosyl compounds//carbohydrate binding -- -- -- -- Cluster-8309.43868 BF_2 1219.50 7.56 7032 546685725 ERL95180.1 4192 0.0e+00 hypothetical protein D910_12448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q80U22 357 7.5e-32 Iporin OS=Mus musculus GN=Rusc2 PE=2 SV=2 PF12025 Phage protein C GO:0019073 viral DNA genome packaging -- -- -- -- -- -- Cluster-8309.43870 BF_2 71.48 0.37 8390 649572303 NP_001280516.1 1401 1.9e-151 V-type proton ATPase subunit H [Tribolium castaneum]>gi|270012170|gb|EFA08618.1| hypothetical protein TcasGA2_TC006281 [Tribolium castaneum]>gi|629511291|gb|AHY84719.1| V-type proton ATPase subunit H variant-2 [Tribolium castaneum] 642931552 XM_961600.3 337 1.76e-173 PREDICTED: Tribolium castaneum V-type proton ATPase subunit H (LOC657235), transcript variant X1, mRNA K02144 ATPeV1H V-type H+-transporting ATPase subunit H http://www.genome.jp/dbget-bin/www_bget?ko:K02144 Q9V3J1 1298 6.9e-141 V-type proton ATPase subunit H OS=Drosophila melanogaster GN=VhaSFD PE=2 SV=2 PF02297//PF02739//PF01602//PF02778//PF00514//PF02985//PF01974//PF11698 Cytochrome oxidase c subunit VIb//5'-3' exonuclease, N-terminal resolvase-like domain//Adaptin N terminal region//tRNA intron endonuclease, N-terminal domain//Armadillo/beta-catenin-like repeat//HEAT repeat//tRNA intron endonuclease, catalytic C-terminal domain//V-ATPase subunit H GO:0051252//GO:0015992//GO:0006123//GO:0006886//GO:0016192//GO:0006388//GO:0015991//GO:0006119 regulation of RNA metabolic process//proton transport//mitochondrial electron transport, cytochrome c to oxygen//intracellular protein transport//vesicle-mediated transport//tRNA splicing, via endonucleolytic cleavage and ligation//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0046961//GO:0004129//GO:0003677//GO:0016820//GO:0005515//GO:0000213 proton-transporting ATPase activity, rotational mechanism//cytochrome-c oxidase activity//DNA binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding//tRNA-intron endonuclease activity GO:0005739//GO:0000214//GO:0030117//GO:0045277//GO:0000221 mitochondrion//tRNA-intron endonuclease complex//membrane coat//respiratory chain complex IV//vacuolar proton-transporting V-type ATPase, V1 domain KOG2759 Vacuolar H+-ATPase V1 sector, subunit H Cluster-8309.43871 BF_2 364.00 7.17 2410 478257950 ENN78088.1 1858 5.6e-205 hypothetical protein YQE_05242, partial [Dendroctonus ponderosae] -- -- -- -- -- K14805 DDX24, MAK5 ATP-dependent RNA helicase DDX24/MAK5 http://www.genome.jp/dbget-bin/www_bget?ko:K14805 Q9ESV0 1075 1.4e-115 ATP-dependent RNA helicase DDX24 OS=Mus musculus GN=Ddx24 PE=1 SV=2 PF06955//PF09798//PF08040//PF00270 Xyloglucan endo-transglycosylase (XET) C-terminus//DNA damage checkpoint protein//MNLL subunit//DEAD/DEAH box helicase GO:0006073//GO:0006118//GO:0000077 cellular glucan metabolic process//obsolete electron transport//DNA damage checkpoint GO:0016762//GO:0003676//GO:0003954//GO:0005524 xyloglucan:xyloglucosyl transferase activity//nucleic acid binding//NADH dehydrogenase activity//ATP binding GO:0005739//GO:0048046//GO:0005618 mitochondrion//apoplast//cell wall KOG0347 RNA helicase Cluster-8309.43872 BF_2 1219.97 21.02 2715 91079112 XP_975371.1 1029 8.5e-109 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 1.3e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF04879//PF16760//PF03423//PF03370 Molybdopterin oxidoreductase Fe4S4 domain//Starch/carbohydrate-binding module (family 53)//Carbohydrate binding domain (family 25)//Carbohydrate/starch-binding module (family 21) GO:0055114 oxidation-reduction process GO:2001070//GO:0005515//GO:0016491 starch binding//protein binding//oxidoreductase activity -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.43873 BF_2 28.86 0.49 2746 91079112 XP_975371.1 1029 8.6e-109 PREDICTED: glycogen-binding subunit 76A [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 Q9VVY3 774 1.3e-80 Glycogen-binding subunit 76A OS=Drosophila melanogaster GN=Gbs-76A PE=1 SV=1 PF03370//PF03423//PF16760 Carbohydrate/starch-binding module (family 21)//Carbohydrate binding domain (family 25)//Starch/carbohydrate-binding module (family 53) -- -- GO:2001070//GO:0005515 starch binding//protein binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.43874 BF_2 501.85 3.27 6707 642920336 XP_008192303.1 1655 5.4e-181 PREDICTED: zinc finger CCCH domain-containing protein 14 isoform X1 [Tribolium castaneum]>gi|270005252|gb|EFA01700.1| hypothetical protein TcasGA2_TC007276 [Tribolium castaneum] 462358939 APGK01029925.1 99 2.82662e-41 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- Q5TYQ8 389 1.4e-35 Zinc finger CCCH domain-containing protein 14 OS=Danio rerio GN=zc3h14 PE=2 SV=1 PF03595//PF01480//PF05830 Voltage-dependent anion channel//PWI domain//Nodulation protein Z (NodZ) GO:0006397//GO:0009312//GO:0055085//GO:0009877 mRNA processing//oligosaccharide biosynthetic process//transmembrane transport//nodulation GO:0016758 transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane KOG3702 Nuclear polyadenylated RNA binding protein Cluster-8309.43875 BF_2 72.31 1.51 2296 91093479 XP_968090.1 360 2.7e-31 PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930712|ref|XP_008199997.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930714|ref|XP_008199998.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930716|ref|XP_008199999.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930718|ref|XP_008200000.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|270012666|gb|EFA09114.1| hypothetical protein TcasGA2_TC015974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.43879 BF_2 527.90 7.17 3367 237681208 NP_001153741.1 1279 1.1e-137 cleavage and polyadenylation specific factor 4, 30kDa [Tribolium castaneum]>gi|270004678|gb|EFA01126.1| hypothetical protein TcasGA2_TC010339 [Tribolium castaneum] 751792985 XM_011207858.1 143 4.90216e-66 PREDICTED: Bactrocera dorsalis cleavage and polyadenylation specificity factor subunit 4 (LOC105228160), mRNA K14404 CPSF4, YTH1 cleavage and polyadenylation specificity factor subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14404 Q9VPT8 848 4.2e-89 Cleavage and polyadenylation specificity factor subunit 4 OS=Drosophila melanogaster GN=Clp PE=1 SV=1 PF03943//PF00642//PF00098 TAP C-terminal domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Zinc knuckle GO:0051028 mRNA transport GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.4388 BF_2 18.33 0.43 2085 564248485 XP_006263331.1 816 3.2e-84 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 755 1.6e-78 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF16622//PF07776//PF13912//PF02892//PF00096//PF13465 zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.43881 BF_2 1213.23 5.73 9145 646710408 KDR15927.1 1190 6.1e-127 La-related protein [Zootermopsis nevadensis] 766937877 XM_011503112.1 182 2.79975e-87 PREDICTED: Ceratosolen solmsi marchali la-related protein CG11505 (LOC105365044), transcript variant X6, mRNA K18763 LARP4 la-related protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18763 Q9I7T7 786 1.8e-81 La-related protein CG11505 OS=Drosophila melanogaster GN=CG11505 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2591 c-Mpl binding protein, contains La domain Cluster-8309.43883 BF_2 126.71 1.75 3311 91092074 XP_971115.1 2158 1.3e-239 PREDICTED: uncharacterized protein LOC659745 [Tribolium castaneum]>gi|270004682|gb|EFA01130.1| hypothetical protein TcasGA2_TC010343 [Tribolium castaneum] 642917993 XM_966022.2 289 3.32714e-147 PREDICTED: Tribolium castaneum uncharacterized LOC659745 (LOC659745), mRNA K10480 BTBD8 BTB/POZ domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10480 Q5XKL5 386 1.5e-35 BTB/POZ domain-containing protein 8 OS=Homo sapiens GN=BTBD8 PE=2 SV=2 PF00651//PF15952 BTB/POZ domain//Enhancer of split M4 family GO:0007423//GO:0007219 sensory organ development//Notch signaling pathway GO:0005515 protein binding -- -- KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.43884 BF_2 49.58 0.78 2947 91083583 XP_968366.1 950 1.3e-99 PREDICTED: adenosylhomocysteinase [Tribolium castaneum]>gi|270007826|gb|EFA04274.1| hypothetical protein TcasGA2_TC014564 [Tribolium castaneum] 751460631 XM_011186787.1 162 1.17439e-76 PREDICTED: Bactrocera cucurbitae adenosylhomocysteinase (LOC105213739), mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q27580 872 6.1e-92 Adenosylhomocysteinase OS=Drosophila melanogaster GN=Ahcy13 PE=2 SV=2 PF02826//PF02254//PF11744//PF01175//PF05221//PF00208 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//TrkA-N domain//Aluminium activated malate transporter//Urocanase//S-adenosyl-L-homocysteine hydrolase//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0006813//GO:0015743//GO:0055114//GO:0006555//GO:0006520//GO:0006547//GO:0006730 potassium ion transport//malate transport//oxidation-reduction process//methionine metabolic process//cellular amino acid metabolic process//histidine metabolic process//one-carbon metabolic process GO:0051287//GO:0004013//GO:0016491//GO:0000166//GO:0016153 NAD binding//adenosylhomocysteinase activity//oxidoreductase activity//nucleotide binding//urocanate hydratase activity -- -- KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.43885 BF_2 9.59 0.58 985 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43889 BF_2 2563.52 60.56 2058 332376366 AEE63323.1 1176 5.8e-126 unknown [Dendroctonus ponderosae]>gi|478253695|gb|ENN73994.1| hypothetical protein YQE_09384, partial [Dendroctonus ponderosae]>gi|546679604|gb|ERL90045.1| hypothetical protein D910_07403 [Dendroctonus ponderosae] 195403178 XM_002060136.1 104 1.42536e-44 Drosophila virilis GJ18493 (Dvir\GJ18493), mRNA -- -- -- -- Q9VXK0 976 3.7e-104 Protein NipSnap OS=Drosophila melanogaster GN=Nipsnap PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2883 NIPSNAP1 protein Cluster-8309.43895 BF_2 1231.10 24.21 2414 91088593 XP_967390.1 873 9.2e-91 PREDICTED: low density lipoprotein receptor adapter protein 1 [Tribolium castaneum]>gi|270012267|gb|EFA08715.1| hypothetical protein TcasGA2_TC006386 [Tribolium castaneum] -- -- -- -- -- K12474 LDLRAP1, ARH low density lipoprotein receptor adapter protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12474 Q67FQ3 337 5.4e-30 Low density lipoprotein receptor adapter protein 1-B OS=Xenopus laevis GN=ldlrap1-b PE=1 SV=1 PF00640//PF08416//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43896 BF_2 295.63 1.21 10499 270003689 EFA00137.1 2104 7.3e-233 hypothetical protein TcasGA2_TC002957 [Tribolium castaneum] 642916224 XM_008192715.1 305 1.35515e-155 PREDICTED: Tribolium castaneum uncharacterized LOC662985 (LOC662985), mRNA -- -- -- -- Q9V5L3 504 1.0e-48 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF02459//PF00631//PF00067//PF00439 Adenoviral DNA terminal protein//GGL domain//Cytochrome P450//Bromodomain GO:0007165//GO:0006260//GO:0007186//GO:0055114 signal transduction//DNA replication//G-protein coupled receptor signaling pathway//oxidation-reduction process GO:0003677//GO:0016705//GO:0005515//GO:0004871//GO:0005506//GO:0020037 DNA binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//protein binding//signal transducer activity//iron ion binding//heme binding GO:0005834 heterotrimeric G-protein complex KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.43897 BF_2 364.31 6.76 2541 189233738 XP_971576.2 1678 4.4e-184 PREDICTED: xaa-Pro dipeptidase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K14213 PEPD Xaa-Pro dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K14213 P12955 1250 7.7e-136 Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0030145//GO:0004177 manganese ion binding//aminopeptidase activity -- -- KOG2737 Putative metallopeptidase Cluster-8309.43898 BF_2 500.48 7.07 3250 91076670 XP_971562.1 2445 6.5e-273 PREDICTED: ATP-binding cassette sub-family F member 1 [Tribolium castaneum]>gi|270002367|gb|EEZ98814.1| hypothetical protein TcasGA2_TC004420 [Tribolium castaneum] 195480796 XM_002101360.1 207 1.25157e-101 Drosophila yakuba GE15656 (Dyak\GE15656), partial mRNA K06184 ABCF1 ATP-binding cassette, subfamily F, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06184 Q767L0 1760 7.2e-195 ATP-binding cassette sub-family F member 1 OS=Sus scrofa GN=ABCF1 PE=3 SV=1 PF03193//PF00005//PF06003//PF03938//PF01008//PF00910//PF13304//PF01926//PF00004//PF07213 Protein of unknown function, DUF258//ABC transporter//Survival motor neuron protein (SMN)//Outer membrane protein (OmpH-like)//Initiation factor 2 subunit family//RNA helicase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//DAP10 membrane protein GO:0050776//GO:0044237//GO:0006200//GO:0007165//GO:0006397//GO:0014068 regulation of immune response//cellular metabolic process//obsolete ATP catabolic process//signal transduction//mRNA processing//positive regulation of phosphatidylinositol 3-kinase signaling GO:0005102//GO:0016887//GO:0051082//GO:0003924//GO:0043548//GO:0005524//GO:0003724//GO:0005525//GO:0003723 receptor binding//ATPase activity//unfolded protein binding//GTPase activity//phosphatidylinositol 3-kinase binding//ATP binding//RNA helicase activity//GTP binding//RNA binding GO:0005737//GO:0016020//GO:0005634 cytoplasm//membrane//nucleus KOG0062 ATPase component of ABC transporters with duplicated ATPase domains/Translation elongation factor EF-3b Cluster-8309.43899 BF_2 37.04 2.30 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04061//PF00335 ORMDL family//Tetraspanin family -- -- -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.4390 BF_2 30.38 0.68 2157 564248485 XP_006263331.1 816 3.4e-84 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 755 1.6e-78 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00075//PF00096//PF13465//PF02892//PF13912//PF07776//PF16622 RNase H//Zinc finger, C2H2 type//Zinc-finger double domain//BED zinc finger//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type GO:0051252 regulation of RNA metabolic process GO:0008270//GO:0003676//GO:0003677//GO:0004523//GO:0046872 zinc ion binding//nucleic acid binding//DNA binding//RNA-DNA hybrid ribonuclease activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.43901 BF_2 323.24 10.67 1555 642933162 XP_974056.2 1933 7.2e-214 PREDICTED: ubiquitin carboxyl-terminal hydrolase nonstop isoform X2 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q9VVR1 1294 3.7e-141 Ubiquitin carboxyl-terminal hydrolase nonstop OS=Drosophila melanogaster GN=not PE=1 SV=3 PF02148//PF00443 Zn-finger in ubiquitin-hydrolases and other protein//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0008270 ubiquitinyl hydrolase activity//zinc ion binding -- -- KOG1867 Ubiquitin-specific protease Cluster-8309.43903 BF_2 935.24 7.53 5481 642935990 XP_008198259.1 4380 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase HECW2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12168 HECW2 E3 ubiquitin-protein ligase HECW2 http://www.genome.jp/dbget-bin/www_bget?ko:K12168 Q9P2P5 1884 5.1e-209 E3 ubiquitin-protein ligase HECW2 OS=Homo sapiens GN=HECW2 PE=1 SV=2 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.43905 BF_2 1225.63 9.77 5537 642927835 XP_972081.2 781 9.9e-80 PREDICTED: LOW QUALITY PROTEIN: probable glucosamine 6-phosphate N-acetyltransferase [Tribolium castaneum] -- -- -- -- -- K00621 GNPNAT1, GNA1 glucosamine-phosphate N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00621 Q9VAI0 611 2.1e-61 Probable glucosamine 6-phosphate N-acetyltransferase OS=Drosophila melanogaster GN=CG1969 PE=2 SV=1 PF13673//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG3396 Glucosamine-phosphate N-acetyltransferase Cluster-8309.43906 BF_2 2.00 3.26 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43907 BF_2 132.02 1.91 3180 91088615 XP_974002.1 834 4.0e-86 PREDICTED: sepiapterin reductase [Tribolium castaneum]>gi|270012265|gb|EFA08713.1| hypothetical protein TcasGA2_TC006384 [Tribolium castaneum] -- -- -- -- -- K00072 SPR sepiapterin reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00072 P35270 313 4.3e-27 Sepiapterin reductase OS=Homo sapiens GN=SPR PE=1 SV=1 PF00769//PF05130//PF12242//PF00106 Ezrin/radixin/moesin family//FlgN protein//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase GO:0044780//GO:0008152//GO:0055114 bacterial-type flagellum assembly//metabolic process//oxidation-reduction process GO:0008092//GO:0016491 cytoskeletal protein binding//oxidoreductase activity GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG1204 Predicted dehydrogenase Cluster-8309.43908 BF_2 9.00 0.37 1312 13625795 AAK35160.1 181 8.7e-11 defensin 1 precursor [Acalolepta luxuriosa] -- -- -- -- -- -- -- -- -- Q27023 157 2.2e-09 Tenecin-1 OS=Tenebrio molitor PE=1 SV=1 PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-8309.43909 BF_2 4.30 0.78 519 642914190 XP_008201582.1 181 3.4e-11 PREDICTED: uncharacterized protein LOC661670 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43911 BF_2 1392.55 4.21 14122 642938921 XP_008195601.1 3295 0.0e+00 PREDICTED: PHD finger protein rhinoceros [Tribolium castaneum] 642938920 XM_008197379.1 365 0 PREDICTED: Tribolium castaneum PHD finger protein rhinoceros (LOC659824), mRNA -- -- -- -- Q7YZH1 1379 4.7e-150 PHD finger protein rhinoceros OS=Drosophila melanogaster GN=rno PE=1 SV=1 PF14560//PF00628//PF00312//PF02214//PF00130//PF02136//PF03708 Ubiquitin-like domain//PHD-finger//Ribosomal protein S15//BTB/POZ domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Nuclear transport factor 2 (NTF2) domain//Avian retrovirus envelope protein, gp85 GO:0051260//GO:0006412//GO:0006810//GO:0035556//GO:0042254 protein homooligomerization//translation//transport//intracellular signal transduction//ribosome biogenesis GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0019031//GO:0005840//GO:0005622 viral envelope//ribosome//intracellular KOG3840 Uncharaterized conserved protein, contains BTB/POZ domain Cluster-8309.43916 BF_2 322.21 2.16 6537 642930787 XP_008196091.1 3440 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.5e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF08069//PF08211//PF02217//PF07531//PF01428//PF00383 Ribosomal S13/S15 N-terminal domain//Cytidine and deoxycytidylate deaminase zinc-binding region//Origin of replication binding protein//NHR1 homology to TAF//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region GO:0006260//GO:0006355//GO:0046087//GO:0042254//GO:0006206//GO:0009972//GO:0006807//GO:0006412 DNA replication//regulation of transcription, DNA-templated//cytidine metabolic process//ribosome biogenesis//pyrimidine nucleobase metabolic process//cytidine deamination//nitrogen compound metabolic process//translation GO:0003735//GO:0008270//GO:0003700//GO:0003688//GO:0004126 structural constituent of ribosome//zinc ion binding//transcription factor activity, sequence-specific DNA binding//DNA replication origin binding//cytidine deaminase activity GO:0005840//GO:0046809//GO:0005667 ribosome//replication compartment//transcription factor complex KOG3183 Predicted Zn-finger protein Cluster-8309.43917 BF_2 558.96 3.27 7443 642930787 XP_008196091.1 3584 0.0e+00 PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|642930789|ref|XP_008196092.1| PREDICTED: dyslexia-associated protein KIAA0319-like protein [Tribolium castaneum]>gi|270011970|gb|EFA08418.1| hypothetical protein TcasGA2_TC006065 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K135 1251 1.7e-135 Dyslexia-associated protein KIAA0319-like protein OS=Mus musculus GN=Kiaa0319l PE=2 SV=1 PF16711//PF02217//PF07531//PF00383//PF01428//PF08211//PF08069 Actin-binding domain of plant-specific actin-binding protein//Origin of replication binding protein//NHR1 homology to TAF//Cytidine and deoxycytidylate deaminase zinc-binding region//AN1-like Zinc finger//Cytidine and deoxycytidylate deaminase zinc-binding region//Ribosomal S13/S15 N-terminal domain GO:0042254//GO:0046087//GO:0006355//GO:0006260//GO:0006412//GO:0006807//GO:0009972//GO:0006206 ribosome biogenesis//cytidine metabolic process//regulation of transcription, DNA-templated//DNA replication//translation//nitrogen compound metabolic process//cytidine deamination//pyrimidine nucleobase metabolic process GO:0003779//GO:0003688//GO:0003700//GO:0003735//GO:0008270//GO:0004126 actin binding//DNA replication origin binding//transcription factor activity, sequence-specific DNA binding//structural constituent of ribosome//zinc ion binding//cytidine deaminase activity GO:0005840//GO:0005667//GO:0046809 ribosome//transcription factor complex//replication compartment KOG3183 Predicted Zn-finger protein Cluster-8309.43919 BF_2 126.00 2.62 2297 91081833 XP_974716.1 1272 4.8e-137 PREDICTED: replication factor C subunit 4 [Tribolium castaneum]>gi|270006308|gb|EFA02756.1| hypothetical protein TcasGA2_TC008489 [Tribolium castaneum] 156849228 XM_001647445.1 73 2.72413e-27 Vanderwaltozyma polyspora DSM 70294 hypothetical protein (Kpol_1018p177) partial mRNA K10755 RFC2_4 replication factor C subunit 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10755 Q99J62 913 8.3e-97 Replication factor C subunit 4 OS=Mus musculus GN=Rfc4 PE=1 SV=1 PF01443//PF05496//PF07728//PF06144//PF00004//PF01637//PF02562//PF04851//PF00270 Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//DNA polymerase III, delta subunit//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0006260//GO:0006310//GO:0006281 DNA replication//DNA recombination//DNA repair GO:0009378//GO:0017111//GO:0003676//GO:0016887//GO:0003887//GO:0003677//GO:0016787//GO:0005524 four-way junction helicase activity//nucleoside-triphosphatase activity//nucleic acid binding//ATPase activity//DNA-directed DNA polymerase activity//DNA binding//hydrolase activity//ATP binding GO:0042575//GO:0009360//GO:0005657//GO:0009379 DNA polymerase complex//DNA polymerase III complex//replication fork//Holliday junction helicase complex KOG0989 Replication factor C, subunit RFC4 Cluster-8309.43922 BF_2 78.26 3.13 1332 478250432 ENN70927.1 600 2.3e-59 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 510 2.6e-50 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00522//PF00656 VPR/VPX protein//Caspase domain GO:0006508//GO:0019058 proteolysis//viral life cycle GO:0004197 cysteine-type endopeptidase activity GO:0042025 host cell nucleus -- -- Cluster-8309.43925 BF_2 90.67 1.08 3792 642919490 XP_008191893.1 2883 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum]>gi|642919492|ref|XP_008191894.1| PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43928 BF_2 1180.48 19.48 2822 91093803 XP_968404.1 863 1.6e-89 PREDICTED: inositol polyphosphate 1-phosphatase [Tribolium castaneum]>gi|270015932|gb|EFA12380.1| hypothetical protein TcasGA2_TC002087 [Tribolium castaneum] -- -- -- -- -- K01107 INPP1 inositol polyphosphate 1-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01107 P49442 655 8.4e-67 Inositol polyphosphate 1-phosphatase OS=Mus musculus GN=Inpp1 PE=2 SV=2 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.43929 BF_2 25.44 0.73 1745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14978 Mitochondrial ribosome protein 63 -- -- -- -- GO:0005761 mitochondrial ribosome -- -- Cluster-8309.43931 BF_2 63.00 8.32 604 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43932 BF_2 1304.92 9.10 6288 642930675 XP_966843.2 4210 0.0e+00 PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 2065 6.0e-230 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.43934 BF_2 67.86 0.99 3154 649572315 NP_001280527.1 2838 0.0e+00 lethal(2) giant larvae protein homolog 1 [Tribolium castaneum]>gi|642930673|ref|XP_008199983.1| PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X1 [Tribolium castaneum]>gi|270012677|gb|EFA09125.1| hypothetical protein TcasGA2_TC015986 [Tribolium castaneum]>gi|625293659|gb|AHY24027.1| lethal giant larvae [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 1450 6.1e-159 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.43935 BF_2 123.76 2.01 2863 642932086 XP_008196851.1 1247 4.7e-134 PREDICTED: solute carrier family 25 member 36-A isoform X2 [Tribolium castaneum] -- -- -- -- -- K15116 SLC25A33_36, RIM2 solute carrier family 25, member 33/36 http://www.genome.jp/dbget-bin/www_bget?ko:K15116 Q6DG32 810 9.1e-85 Solute carrier family 25 member 36-A OS=Danio rerio GN=slc25a36a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0757 Mitochondrial carrier protein - Rim2p/Mrs12p Cluster-8309.43936 BF_2 1136.57 18.08 2917 91088711 XP_975115.1 1328 1.9e-143 PREDICTED: solute carrier family 25 member 36-A isoform X1 [Tribolium castaneum]>gi|270012292|gb|EFA08740.1| hypothetical protein TcasGA2_TC006415 [Tribolium castaneum] -- -- -- -- -- K15116 SLC25A33_36, RIM2 solute carrier family 25, member 33/36 http://www.genome.jp/dbget-bin/www_bget?ko:K15116 Q6DG32 745 3.2e-77 Solute carrier family 25 member 36-A OS=Danio rerio GN=slc25a36a PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0757 Mitochondrial carrier protein - Rim2p/Mrs12p Cluster-8309.43938 BF_2 306.31 1.76 7557 270001017 EEZ97464.1 919 1.3e-95 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 726 1.3e-74 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF03540//PF02137//PF07297 Transcription initiation factor TFIID 23-30kDa subunit//Adenosine-deaminase (editase) domain//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GO:0006144//GO:0009059//GO:0006352//GO:0006807//GO:0006396 purine nucleobase metabolic process//macromolecule biosynthetic process//DNA-templated transcription, initiation//nitrogen compound metabolic process//RNA processing GO:0003723//GO:0004000 RNA binding//adenosine deaminase activity GO:0005634//GO:0030176 nucleus//integral component of endoplasmic reticulum membrane KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.43939 BF_2 107.21 0.52 8866 270001017 EEZ97464.1 369 9.4e-32 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 337 2.0e-29 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137//PF07297 Adenosine-deaminase (editase) domain//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) GO:0006396//GO:0009059//GO:0006807//GO:0006144 RNA processing//macromolecule biosynthetic process//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0004000//GO:0003723 adenosine deaminase activity//RNA binding GO:0030176 integral component of endoplasmic reticulum membrane KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.43940 BF_2 1610.64 15.91 4521 91079889 XP_968047.1 4005 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 47 [Tribolium castaneum] 752892515 XM_011266045.1 165 3.88904e-78 PREDICTED: Camponotus floridanus ubiquitin carboxyl-terminal hydrolase 47 (LOC105256270), transcript variant X2, mRNA K11857 USP47 ubiquitin carboxyl-terminal hydrolase 47 http://www.genome.jp/dbget-bin/www_bget?ko:K11857 Q24574 1707 1.4e-188 Ubiquitin carboxyl-terminal hydrolase 64E OS=Drosophila melanogaster GN=Ubp64E PE=1 SV=2 PF00443//PF00240//PF14560 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin family//Ubiquitin-like domain GO:0016579 protein deubiquitination GO:0005515//GO:0036459 protein binding//ubiquitinyl hydrolase activity -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.43942 BF_2 405.53 3.00 5941 642925021 XP_008194139.1 3725 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X3 [Tribolium castaneum] 462328174 APGK01040787.1 46 7.26165e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 6.1e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.43944 BF_2 98.44 2.40 2006 91077554 XP_972108.1 1153 2.6e-123 PREDICTED: 39S ribosomal protein L2, mitochondrial [Tribolium castaneum]>gi|270001586|gb|EEZ98033.1| hypothetical protein TcasGA2_TC000434 [Tribolium castaneum] -- -- -- -- -- K02886 RP-L2, MRPL2, rplB large subunit ribosomal protein L2 http://www.genome.jp/dbget-bin/www_bget?ko:K02886 Q498T4 482 6.9e-47 39S ribosomal protein L2, mitochondrial OS=Rattus norvegicus GN=Mrpl2 PE=2 SV=1 PF00181//PF03947 Ribosomal Proteins L2, RNA binding domain//Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0438 Mitochondrial/chloroplast ribosomal protein L2 Cluster-8309.43945 BF_2 21.05 0.31 3167 189234632 XP_001815875.1 994 1.1e-104 PREDICTED: uncharacterized protein LOC100141793 [Tribolium castaneum]>gi|270002124|gb|EEZ98571.1| hypothetical protein TcasGA2_TC001083 [Tribolium castaneum] 645023008 XM_003425366.2 61 1.76622e-20 PREDICTED: Nasonia vitripennis uncharacterized LOC100678221 (LOC100678221), transcript variant X13, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43947 BF_2 686.30 8.27 3759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07677//PF06387 A-macroglobulin receptor//D1 dopamine receptor-interacting protein (calcyon) GO:0048268//GO:0007212 clathrin coat assembly//dopamine receptor signaling pathway GO:0032051 clathrin light chain binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.43949 BF_2 285.37 6.85 2031 478255214 ENN75443.1 689 1.7e-69 hypothetical protein YQE_07994, partial [Dendroctonus ponderosae]>gi|546675119|gb|ERL86366.1| hypothetical protein D910_03774 [Dendroctonus ponderosae] -- -- -- -- -- K17499 PPM1G, PP2CG protein phosphatase 1G http://www.genome.jp/dbget-bin/www_bget?ko:K17499 Q7K4Q5 586 6.1e-59 Probable protein phosphatase CG10417 OS=Drosophila melanogaster GN=CG10417 PE=1 SV=1 PF00481 Protein phosphatase 2C -- -- GO:0003824 catalytic activity -- -- KOG0698 Serine/threonine protein phosphatase Cluster-8309.43950 BF_2 331.17 7.94 2033 167444210 ABZ80666.1 1036 9.8e-110 tollip-like protein [Sitophilus zeamais] -- -- -- -- -- K05402 TOLLIP toll-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05402 A2RUW1 649 3.0e-66 Toll-interacting protein OS=Rattus norvegicus GN=Tollip PE=2 SV=1 PF02845//PF00168 CUE domain//C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.43951 BF_2 50.20 0.48 4652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.43952 BF_2 120.40 1.01 5272 270007730 EFA04178.1 469 1.4e-43 hypothetical protein TcasGA2_TC014427 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9C0D2 153 2.6e-08 Centrosomal protein of 295 kDa OS=Homo sapiens GN=CEP295 PE=2 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43954 BF_2 14.21 0.63 1225 478252606 ENN73011.1 751 6.6e-77 hypothetical protein YQE_10346, partial [Dendroctonus ponderosae]>gi|546677977|gb|ERL88706.1| hypothetical protein D910_06088 [Dendroctonus ponderosae] 704163529 XM_010146261.1 149 8.09309e-70 PREDICTED: Buceros rhinoceros silvestris cell division cycle 42 (CDC42), transcript variant X2, mRNA K04393 CDC42 cell division control protein 42 http://www.genome.jp/dbget-bin/www_bget?ko:K04393 Q17031 730 7.3e-76 Cdc42 homolog OS=Anopheles gambiae GN=Cdc42 PE=2 SV=2 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.43957 BF_2 601.99 141.38 465 270297202 NP_001161902.1 515 5.8e-50 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 374 5.3e-35 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- GO:0008152 metabolic process GO:0033961 cis-stilbene-oxide hydrolase activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.43958 BF_2 35.67 2.73 834 270297202 NP_001161902.1 620 6.9e-62 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 462 6.0e-45 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 PF00906 Hepatitis core antigen GO:0009405 pathogenesis GO:0016787//GO:0005198 hydrolase activity//structural molecule activity -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.43959 BF_2 62.40 0.56 4942 817011235 AKF11871.1 1486 1.6e-161 putative juvenile hormone epoxide hydrolase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 1230 3.1e-133 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 PF00993 Class II histocompatibility antigen, alpha domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0042613//GO:0016020 MHC class II protein complex//membrane KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.4396 BF_2 15.94 0.56 1488 642918175 XP_008191397.1 1135 2.4e-121 PREDICTED: glycosyltransferase-like domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXN0 820 3.3e-86 Glycosyltransferase-like domain-containing protein 1-like OS=Drosophila melanogaster GN=CG15914 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43961 BF_2 48.68 1.11 2114 91084843 XP_966905.1 1225 1.2e-131 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 840 2.2e-88 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01370//PF01073 Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family GO:0008210//GO:0055114//GO:0006694//GO:0008209//GO:0008207 estrogen metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0003854//GO:0050662//GO:0003824//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.43963 BF_2 160.08 4.33 1835 91079236 XP_970901.1 1361 1.8e-147 PREDICTED: tubulin-specific chaperone E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KS0 795 3.2e-83 Tubulin-specific chaperone E OS=Bos taurus GN=TBCE PE=2 SV=1 PF00564//PF13855 PB1 domain//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG3207 Beta-tubulin folding cofactor E Cluster-8309.43966 BF_2 109.95 0.98 4994 571522851 XP_006560648.1 2180 5.3e-242 PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X3 [Apis mellifera]>gi|572299843|ref|XP_006616037.1| PREDICTED: zinc finger SWIM domain-containing protein 8-like isoform X2 [Apis dorsata]>gi|820834524|ref|XP_012348863.1| PREDICTED: zinc finger SWIM domain-containing protein 8 isoform X2 [Apis florea] 195132728 XM_002010759.1 175 1.18691e-83 Drosophila mojavensis GI21737 (Dmoj\GI21737), mRNA -- -- -- -- A7E2V4 1086 1.6e-116 Zinc finger SWIM domain-containing protein 8 OS=Homo sapiens GN=ZSWIM8 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3615 Uncharacterized conserved protein Cluster-8309.43970 BF_2 43.27 2.62 977 546680730 ERL90956.1 961 2.3e-101 hypothetical protein D910_08298 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R599 496 8.0e-49 Translin-associated protein X OS=Macaca fascicularis GN=TSNAX PE=2 SV=1 PF01997 Translin family -- -- GO:0043565 sequence-specific DNA binding -- -- KOG3066 Translin-associated protein X Cluster-8309.43971 BF_2 275.80 4.85 2668 728417098 AIY68333.1 793 1.9e-81 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 522 2.1e-51 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.43972 BF_2 114.57 1.25 4134 642917767 XP_008191359.1 1275 3.8e-137 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 512 4.7e-50 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF02254//PF05199//PF07992//PF05834//PF00732//PF01266 TrkA-N domain//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0055114//GO:0016117//GO:0006813//GO:0044710 oxidation-reduction process//carotenoid biosynthetic process//potassium ion transport//single-organism metabolic process GO:0050660//GO:0016491//GO:0016614//GO:0016705 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.43973 BF_2 77.14 1.28 2807 642931467 XP_966826.3 1593 3.5e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 1.0e-19 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.43974 BF_2 15.79 0.54 1507 642931467 XP_966826.3 924 7.0e-97 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6PEM8 149 2.1e-08 Proton-coupled folate transporter OS=Mus musculus GN=Slc46a1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.43975 BF_2 204.97 1.07 8290 642914685 XP_008190314.1 4543 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.31246e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 1636 4.4e-180 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 PF00069//PF07714//PF16656//PF00041 Protein kinase domain//Protein tyrosine kinase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497//GO:0006468 riboflavin metabolic process//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0046872//GO:0004672//GO:0003993//GO:0005515//GO:0005524 metal ion binding//protein kinase activity//acid phosphatase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.43976 BF_2 1166.85 6.09 8296 642914685 XP_008190314.1 7291 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: proto-oncogene tyrosine-protein kinase ROS [Tribolium castaneum] 695158202 XM_009508869.1 44 1.31341e-10 PREDICTED: Phalacrocorax carbo ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), mRNA K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 Q78DX7 2253 1.2e-251 Proto-oncogene tyrosine-protein kinase ROS OS=Mus musculus GN=Ros1 PE=1 SV=1 PF00069//PF07714//PF16656//PF00041 Protein kinase domain//Protein tyrosine kinase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0006468//GO:0019497 riboflavin metabolic process//protein phosphorylation//hexachlorocyclohexane metabolic process GO:0003993//GO:0004672//GO:0046872//GO:0005524//GO:0005515 acid phosphatase activity//protein kinase activity//metal ion binding//ATP binding//protein binding -- -- -- -- Cluster-8309.43977 BF_2 711.07 9.33 3477 478260834 ENN80486.1 1804 1.5e-198 hypothetical protein YQE_03090, partial [Dendroctonus ponderosae] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q5F364 1548 2.9e-170 Multidrug resistance-associated protein 1 OS=Gallus gallus GN=ABCC1 PE=2 SV=1 PF00664//PF01926//PF13304//PF00005//PF03193 ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0055085 transport//transmembrane transport GO:0042626//GO:0016887//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.4398 BF_2 5.00 0.69 589 318087128 ADV40156.1 823 1.4e-85 putative 14-3-3 protein isoform 2 [Latrodectus hesperus] -- -- -- -- -- K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 Q2F637 767 1.8e-80 14-3-3 protein zeta OS=Bombyx mori GN=14-3-3zeta PE=2 SV=2 PF13181//PF15499//PF02154 Tetratricopeptide repeat//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Flagellar motor switch protein FliM GO:0071973 bacterial-type flagellum-dependent cell motility GO:0005515//GO:0032183//GO:0003774//GO:0070140 protein binding//SUMO binding//motor activity//SUMO-specific isopeptidase activity GO:0009425 bacterial-type flagellum basal body -- -- Cluster-8309.43981 BF_2 20.01 0.78 1356 270003787 EFA00235.1 713 1.9e-72 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 642915737 XM_008192562.1 189 5.21907e-92 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X3, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q0KL02 317 6.3e-28 Triple functional domain protein OS=Mus musculus GN=Trio PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.43982 BF_2 86.54 0.32 11723 642927139 XP_008195153.1 8604 0.0e+00 PREDICTED: talin-1 isoform X1 [Tribolium castaneum]>gi|642927141|ref|XP_008195154.1| PREDICTED: talin-1 isoform X1 [Tribolium castaneum] 462478154 APGK01000083.1 98 1.78117e-40 Dendroctonus ponderosae Seq01000083, whole genome shotgun sequence K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y4G6 4957 0.0e+00 Talin-2 OS=Homo sapiens GN=TLN2 PE=1 SV=4 PF01608//PF01044//PF02174//PF09141//PF01025 I/LWEQ domain//Vinculin family//PTB domain (IRS-1 type)//Talin, middle domain//GrpE GO:0007016//GO:0007165//GO:0006457//GO:0007155 cytoskeletal anchoring at plasma membrane//signal transduction//protein folding//cell adhesion GO:0003779//GO:0005158//GO:0042803//GO:0005200//GO:0051087//GO:0051015//GO:0000774 actin binding//insulin receptor binding//protein homodimerization activity//structural constituent of cytoskeleton//chaperone binding//actin filament binding//adenyl-nucleotide exchange factor activity GO:0005899//GO:0001726//GO:0005856//GO:0005925 insulin receptor complex//ruffle//cytoskeleton//focal adhesion KOG4261 Talin Cluster-8309.43983 BF_2 24.46 0.54 2168 91088497 XP_971106.1 1288 6.3e-139 PREDICTED: hydroxysteroid dehydrogenase-like protein 2 [Tribolium castaneum]>gi|270012748|gb|EFA09196.1| hypothetical protein TcasGA2_TC005801 [Tribolium castaneum] 195430189 XM_002063103.1 51 4.35971e-15 Drosophila willistoni GK21765 (Dwil\GK21765), mRNA -- -- -- -- Q6PAY8 1029 2.8e-110 Hydroxysteroid dehydrogenase-like protein 2 OS=Xenopus laevis GN=hsdl2 PE=2 SV=1 PF12242//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0032934//GO:0016491//GO:0000166 sterol binding//oxidoreductase activity//nucleotide binding -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.43984 BF_2 26.51 0.55 2296 478260883 ENN80520.1 505 4.1e-48 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZR5 151 1.9e-08 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Homo sapiens GN=CMTM4 PE=1 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.43987 BF_2 1090.50 11.78 4160 270013807 EFA10255.1 3315 0.0e+00 hypothetical protein TcasGA2_TC012455 [Tribolium castaneum] -- -- -- -- -- K04648 DCTN1 dynactin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04648 P13496 2104 1.2e-234 Dynactin subunit 1 OS=Drosophila melanogaster GN=Gl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0971 Microtubule-associated protein dynactin DCTN1/Glued Cluster-8309.43988 BF_2 120.94 1.22 4451 642934746 XP_008197795.1 2989 0.0e+00 PREDICTED: dynactin subunit 1 [Tribolium castaneum] -- -- -- -- -- K04648 DCTN1 dynactin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04648 P13496 1855 9.5e-206 Dynactin subunit 1 OS=Drosophila melanogaster GN=Gl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0971 Microtubule-associated protein dynactin DCTN1/Glued Cluster-8309.43990 BF_2 101.77 1.25 3699 642927970 XP_972030.2 3284 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 255552749 XM_002517372.1 35 5.86839e-06 Ricinus communis mannosidase alpha class 2a, putative, mRNA K01231 MAN2 alpha-mannosidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01231 Q24451 1997 2.7e-222 Alpha-mannosidase 2 OS=Drosophila melanogaster GN=alpha-Man-II PE=1 SV=2 PF09261//PF01074//PF07748//PF08053 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Tryptophanase operon leader peptide GO:0031554//GO:0031556//GO:0006013//GO:0005975 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome//mannose metabolic process//carbohydrate metabolic process GO:0004553//GO:0004559//GO:0015923//GO:0008270 hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-mannosidase activity//mannosidase activity//zinc ion binding -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.43992 BF_2 377.34 4.03 4203 642927970 XP_972030.2 4255 0.0e+00 PREDICTED: alpha-mannosidase 2 [Tribolium castaneum] 255552749 XM_002517372.1 35 6.67583e-06 Ricinus communis mannosidase alpha class 2a, putative, mRNA K01231 MAN2 alpha-mannosidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01231 Q24451 2373 7.7e-266 Alpha-mannosidase 2 OS=Drosophila melanogaster GN=alpha-Man-II PE=1 SV=2 PF09261//PF07748//PF08053//PF01074 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 C-terminal domain//Tryptophanase operon leader peptide//Glycosyl hydrolases family 38 N-terminal domain GO:0031554//GO:0031556//GO:0005975//GO:0006013 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome//carbohydrate metabolic process//mannose metabolic process GO:0004553//GO:0015923//GO:0004559//GO:0008270 hydrolase activity, hydrolyzing O-glycosyl compounds//mannosidase activity//alpha-mannosidase activity//zinc ion binding -- -- KOG1958 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.43993 BF_2 17.81 0.81 1205 607357065 EZA51539.1 229 2.2e-16 hypothetical protein X777_09786 [Cerapachys biroi] 462299627 APGK01051253.1 52 6.649e-16 Dendroctonus ponderosae Seq01051263, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44003 BF_2 153.24 3.09 2359 -- -- -- -- -- 642912782 XM_008203028.1 89 3.5696e-36 PREDICTED: Tribolium castaneum held out wings (how), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44004 BF_2 380.12 9.67 1932 642923427 XP_008193740.1 1289 4.3e-139 PREDICTED: alpha-tocopherol transfer protein-like isoform X2 [Tribolium castaneum]>gi|270007646|gb|EFA04094.1| hypothetical protein TcasGA2_TC014329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6JFQ6 386 9.0e-36 Clavesin-1 OS=Rattus norvegicus GN=Clvs1 PE=1 SV=1 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.44006 BF_2 587.04 2.75 9213 270002460 EEZ98907.1 3799 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF07649//PF01363 Zn-finger in ubiquitin-hydrolases and other protein//C1-like domain//FYVE zinc finger GO:0055114 oxidation-reduction process GO:0008270//GO:0047134//GO:0046872 zinc ion binding//protein-disulfide reductase activity//metal ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44007 BF_2 260.91 1.22 9269 270002460 EEZ98907.1 5010 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1802 2.8e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF02148//PF07649//PF01363 Zn-finger in ubiquitin-hydrolases and other protein//C1-like domain//FYVE zinc finger GO:0055114 oxidation-reduction process GO:0046872//GO:0047134//GO:0008270 metal ion binding//protein-disulfide reductase activity//zinc ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44008 BF_2 287.65 2.50 5093 642912265 XP_008200629.1 1187 7.6e-127 PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912267|ref|XP_008200630.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912269|ref|XP_008200631.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q6IRB8 281 3.5e-23 Lysine-specific demethylase 3A-A OS=Xenopus laevis GN=kdm3a-a PE=2 SV=1 PF01498 Transposase GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677 DNA binding -- -- -- -- Cluster-8309.44009 BF_2 62.34 0.68 4112 478251563 ENN72025.1 1955 5.4e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 3.5e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.44010 BF_2 504.20 3.99 5571 91078406 XP_974522.1 2008 5.2e-222 PREDICTED: cirhin [Tribolium castaneum]>gi|270003991|gb|EFA00439.1| hypothetical protein TcasGA2_TC003293 [Tribolium castaneum] -- -- -- -- -- K14548 UTP4, CIRH1A U3 small nucleolar RNA-associated protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14548 Q969X6 742 1.4e-76 Cirhin OS=Homo sapiens GN=CIRH1A PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2048 WD40 repeat protein Cluster-8309.44011 BF_2 88.78 0.60 6435 642924086 XP_008194000.1 2791 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X2 [Tribolium castaneum] 194751946 XM_001958249.1 59 4.66727e-19 Drosophila ananassae GF23597 (Dana\GF23597), mRNA K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q9VW47 1468 1.0e-160 Mediator of RNA polymerase II transcription subunit 12 OS=Drosophila melanogaster GN=kto PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3598 Thyroid hormone receptor-associated protein complex, subunit TRAP230 Cluster-8309.44012 BF_2 548.02 2.57 9210 642913168 XP_008201419.1 1661 1.5e-181 PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum]>gi|642913170|ref|XP_008201420.1| PREDICTED: myosin heavy chain 95F isoform X1 [Tribolium castaneum] 642913399 XM_008202772.1 149 6.23456e-69 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X3, mRNA K10358 MYO6 myosin VI http://www.genome.jp/dbget-bin/www_bget?ko:K10358 Q01989 1300 4.4e-141 Myosin heavy chain 95F OS=Drosophila melanogaster GN=jar PE=2 SV=4 PF13465//PF01363//PF13912//PF02724//PF02892//PF02487//PF06459//PF00096//PF01943//PF00063//PF00612 Zinc-finger double domain//FYVE zinc finger//C2H2-type zinc finger//CDC45-like protein//BED zinc finger//CLN3 protein//Ryanodine Receptor TM 4-6//Zinc finger, C2H2 type//Polysaccharide biosynthesis protein//Myosin head (motor domain)//IQ calmodulin-binding motif GO:0000271//GO:0006816//GO:0006270//GO:0006874 polysaccharide biosynthetic process//calcium ion transport//DNA replication initiation//cellular calcium ion homeostasis GO:0005524//GO:0003677//GO:0005219//GO:0005515//GO:0003774//GO:0046872 ATP binding//DNA binding//ryanodine-sensitive calcium-release channel activity//protein binding//motor activity//metal ion binding GO:0016021//GO:0016459//GO:0005622//GO:0016020 integral component of membrane//myosin complex//intracellular//membrane KOG0163 Myosin class VI heavy chain Cluster-8309.44014 BF_2 159.78 0.86 8097 642926340 XP_008194885.1 3619 0.0e+00 PREDICTED: small G protein signaling modulator 1 isoform X1 [Tribolium castaneum]>gi|270009053|gb|EFA05501.1| hypothetical protein TcasGA2_TC015686 [Tribolium castaneum] 195482092 XM_002101873.1 376 0 Drosophila yakuba GE17884 (Dyak\GE17884), partial mRNA -- -- -- -- Q8BPQ7 2332 8.4e-261 Small G protein signaling modulator 1 OS=Mus musculus GN=Sgsm1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1648 Uncharacterized conserved protein, contains RUN, BRK and TBC domains Cluster-8309.44019 BF_2 8.00 1.44 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44020 BF_2 23.17 0.97 1290 -- -- -- -- -- 755883564 XM_005186518.2 34 7.23367e-06 PREDICTED: Musca domestica cytoplasmic phosphatidylinositol transfer protein 1 (LOC101895494), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44023 BF_2 2446.92 31.55 3532 546673138 ERL84803.1 2449 2.4e-273 hypothetical protein D910_02228 [Dendroctonus ponderosae] 645036531 XM_001607427.3 100 4.12052e-42 PREDICTED: Nasonia vitripennis ribulose-phosphate 3-epimerase (LOC100121800), mRNA K01937 pyrG, CTPS CTP synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01937 Q2M197 1861 1.5e-206 CTP synthase OS=Drosophila pseudoobscura pseudoobscura GN=CTPsyn PE=3 SV=2 PF16941//PF00215//PF07722//PF06418//PF01729//PF00834 Putative cyclodextrin porin//Orotidine 5'-phosphate decarboxylase / HUMPS family//Peptidase C26//CTP synthase N-terminus//Quinolinate phosphoribosyl transferase, C-terminal domain//Ribulose-phosphate 3 epimerase family GO:0005975//GO:0006541//GO:0009435//GO:0006206//GO:0046497//GO:0006221//GO:0098657//GO:0006207 carbohydrate metabolic process//glutamine metabolic process//NAD biosynthetic process//pyrimidine nucleobase metabolic process//nicotinate nucleotide metabolic process//pyrimidine nucleotide biosynthetic process//import into cell//'de novo' pyrimidine nucleobase biosynthetic process GO:0004514//GO:0004590//GO:0003883//GO:0016787//GO:0016857 nicotinate-nucleotide diphosphorylase (carboxylating) activity//orotidine-5'-phosphate decarboxylase activity//CTP synthase activity//hydrolase activity//racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG2387 CTP synthase (UTP-ammonia lyase) Cluster-8309.44024 BF_2 111.08 2.52 2132 478260221 ENN79984.1 224 1.5e-15 hypothetical protein YQE_03578, partial [Dendroctonus ponderosae]>gi|546675215|gb|ERL86451.1| hypothetical protein D910_03858 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44025 BF_2 371.62 5.15 3306 642917516 XP_969396.3 1985 1.4e-219 PREDICTED: fragile X mental retardation syndrome-related protein 1 isoform X2 [Tribolium castaneum] 642917515 XM_964303.3 446 0 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X2, mRNA K15516 FMR fragile X mental retardation protein http://www.genome.jp/dbget-bin/www_bget?ko:K15516 Q9NFU0 1214 1.5e-131 Fragile X mental retardation syndrome-related protein 1 OS=Drosophila melanogaster GN=Fmr1 PE=1 SV=1 PF13184//PF13014//PF00013//PF12235//PF07650//PF06331 NusA-like KH domain//KH domain//KH domain//Fragile X-related 1 protein core C terminal//KH domain//Transcription factor TFIIH complex subunit Tfb5 GO:0006355//GO:0006289 regulation of transcription, DNA-templated//nucleotide-excision repair GO:0003723 RNA binding GO:0000439 core TFIIH complex -- -- Cluster-8309.44026 BF_2 166.37 9.11 1051 642917518 XP_008191235.1 181 7.0e-11 PREDICTED: fragile X mental retardation syndrome-related protein 1 isoform X3 [Tribolium castaneum] 642917523 XM_008193017.1 66 9.53829e-24 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44028 BF_2 1053.89 14.71 3284 642917516 XP_969396.3 1985 1.4e-219 PREDICTED: fragile X mental retardation syndrome-related protein 1 isoform X2 [Tribolium castaneum] 642917515 XM_964303.3 446 0 PREDICTED: Tribolium castaneum fragile X mental retardation syndrome-related protein 1 (LOC657873), transcript variant X2, mRNA K15516 FMR fragile X mental retardation protein http://www.genome.jp/dbget-bin/www_bget?ko:K15516 Q9NFU0 1214 1.5e-131 Fragile X mental retardation syndrome-related protein 1 OS=Drosophila melanogaster GN=Fmr1 PE=1 SV=1 PF06331//PF07650//PF12235//PF00013//PF13184//PF13014 Transcription factor TFIIH complex subunit Tfb5//KH domain//Fragile X-related 1 protein core C terminal//KH domain//NusA-like KH domain//KH domain GO:0006355//GO:0006289 regulation of transcription, DNA-templated//nucleotide-excision repair GO:0003723 RNA binding GO:0000439 core TFIIH complex -- -- Cluster-8309.44029 BF_2 659.59 6.81 4336 478257240 ENN77403.1 3447 0.0e+00 hypothetical protein YQE_06228, partial [Dendroctonus ponderosae] 768451728 XM_011569773.1 111 3.8903e-48 PREDICTED: Plutella xylostella GTPase-activating protein-like (LOC105397755), partial mRNA K12380 RASA3 Ras GTPase-activating protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12380 Q14644 1808 2.6e-200 Ras GTPase-activating protein 3 OS=Homo sapiens GN=RASA3 PE=1 SV=3 PF00779//PF00616//PF00168 BTK motif//GTPase-activator protein for Ras-like GTPase//C2 domain GO:0043087//GO:0035556 regulation of GTPase activity//intracellular signal transduction GO:0005515 protein binding -- -- KOG2059 Ras GTPase-activating protein Cluster-8309.44030 BF_2 240.44 3.53 3138 642939832 XP_008190719.1 942 1.2e-98 PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum]>gi|642939834|ref|XP_008190783.1| PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CCG1 288 3.4e-24 Zinc finger C2HC domain-containing protein 1C OS=Mus musculus GN=Zc2hc1c PE=2 SV=1 PF13465//PF00096//PF02313//PF01155//PF05191//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//Fumarate reductase subunit D//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0006144//GO:0046034//GO:0006464//GO:0006106 purine nucleobase metabolic process//ATP metabolic process//cellular protein modification process//fumarate metabolic process GO:0016151//GO:0004017//GO:0046872 nickel cation binding//adenylate kinase activity//metal ion binding GO:0016020 membrane KOG3940 Uncharacterized conserved protein Cluster-8309.44031 BF_2 1193.36 21.89 2568 642926791 XP_008195017.1 410 4.8e-37 PREDICTED: uncharacterized protein LOC103313467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44034 BF_2 42.01 0.52 3642 642915289 XP_975869.2 1723 3.8e-189 PREDICTED: RING finger and SPRY domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R881 1177 3.2e-127 RING finger and SPRY domain-containing protein 1 OS=Pongo abelii GN=RSPRY1 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.44038 BF_2 1511.00 85.32 1028 649572227 NP_001280512.1 1435 2.7e-156 clathrin heavy chain [Tribolium castaneum]>gi|270008499|gb|EFA04947.1| hypothetical protein TcasGA2_TC015014 [Tribolium castaneum]>gi|629511285|gb|AHY84716.1| clathrin heavy chain [Tribolium castaneum] 649572226 NM_001293583.1 402 0 Tribolium castaneum clathrin heavy chain (LOC656193), mRNA >gnl|BL_ORD_ID|19160611 Tribolium castaneum strain Georgia-1 clathrin heavy chain (Chc) mRNA, complete cds K04646 CLTC clathrin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K04646 P49951 1195 7.4e-130 Clathrin heavy chain 1 OS=Bos taurus GN=CLTC PE=1 SV=1 -- -- GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198 structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle KOG0985 Vesicle coat protein clathrin, heavy chain Cluster-8309.44041 BF_2 1.00 6.73 244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44042 BF_2 4374.84 47.70 4124 642919579 XP_008191929.1 3085 0.0e+00 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q61316 1858 3.9e-206 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF02862//PF04355//PF06723 DDHD domain//SmpA / OmlA family//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005524//GO:0046872 ATP binding//metal ion binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.44043 BF_2 11.00 34.51 268 270015668 EFA12116.1 188 2.8e-12 hypothetical protein TcasGA2_TC002262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.44044 BF_2 301.57 11.54 1380 91086175 XP_970802.1 1231 1.6e-132 PREDICTED: L-asparaginase isoform X1 [Tribolium castaneum]>gi|270009879|gb|EFA06327.1| hypothetical protein TcasGA2_TC009198 [Tribolium castaneum] -- -- -- -- -- K13278 ASPG 60kDa lysophospholipase http://www.genome.jp/dbget-bin/www_bget?ko:K13278 Q9U518 818 5.2e-86 L-asparaginase OS=Dirofilaria immitis PE=1 SV=1 PF00710 Asparaginase GO:0006522//GO:0006528//GO:0006520//GO:0006531 alanine metabolic process//asparagine metabolic process//cellular amino acid metabolic process//aspartate metabolic process GO:0004067 asparaginase activity -- -- KOG0503 Asparaginase Cluster-8309.44046 BF_2 26.61 1.49 1033 607303795 EZA45171.1 364 4.2e-32 lipase 3-like protein-1, partial [Microplitis demolitor] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 Q5VXJ0 277 2.1e-23 Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2 PF02450//PF04083 Lecithin:cholesterol acyltransferase//Partial alpha/beta-hydrolase lipase region GO:0006629//GO:0042967 lipid metabolic process//acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.44047 BF_2 495.23 4.40 4996 642913326 XP_008195269.1 1969 1.6e-217 PREDICTED: protein roadkill isoform X3 [Tribolium castaneum] 817216130 XM_012428712.1 388 0 PREDICTED: Orussus abietinus protein roadkill (LOC105701723), transcript variant X5, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1774 2.6e-196 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF05355//PF00917//PF00651 Apolipoprotein C-II//MATH domain//BTB/POZ domain GO:0006869//GO:0006629 lipid transport//lipid metabolic process GO:0005515//GO:0008047 protein binding//enzyme activator activity GO:0042627 chylomicron KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.44048 BF_2 264.56 2.44 4821 642913326 XP_008195269.1 1984 2.7e-219 PREDICTED: protein roadkill isoform X3 [Tribolium castaneum] 817216130 XM_012428712.1 388 0 PREDICTED: Orussus abietinus protein roadkill (LOC105701723), transcript variant X5, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1774 2.5e-196 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF00651//PF00917//PF05355 BTB/POZ domain//MATH domain//Apolipoprotein C-II GO:0006629//GO:0006869 lipid metabolic process//lipid transport GO:0005515//GO:0008047 protein binding//enzyme activator activity GO:0042627 chylomicron KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.44051 BF_2 358.98 3.35 4770 270001755 EEZ98202.1 1966 3.3e-217 hypothetical protein TcasGA2_TC000632 [Tribolium castaneum] 817216130 XM_012428712.1 388 0 PREDICTED: Orussus abietinus protein roadkill (LOC105701723), transcript variant X5, mRNA K10523 SPOP speckle-type POZ protein http://www.genome.jp/dbget-bin/www_bget?ko:K10523 Q9VFP2 1770 7.3e-196 Protein roadkill OS=Drosophila melanogaster GN=rdx PE=1 SV=2 PF00651//PF00917//PF05355 BTB/POZ domain//MATH domain//Apolipoprotein C-II GO:0006869//GO:0006629 lipid transport//lipid metabolic process GO:0008047//GO:0005515 enzyme activator activity//protein binding GO:0042627 chylomicron KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.44054 BF_2 668.17 20.00 1685 642925814 XP_970128.3 720 3.6e-73 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 524 7.8e-52 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0050662//GO:0003824 oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.44055 BF_2 80.29 1.69 2269 270008593 EFA05041.1 2628 2.7e-294 hypothetical protein TcasGA2_TC015132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96AY4 1597 4.0e-176 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 PF07721//PF13181//PF10579//PF13414//PF13176//PF13374//PF00515//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0007268 synaptic transmission GO:0042802//GO:0033130//GO:0043495//GO:0005515 identical protein binding//acetylcholine receptor binding//protein anchor//protein binding -- -- KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain Cluster-8309.44056 BF_2 3.00 6.99 279 270008593 EFA05041.1 420 3.6e-39 hypothetical protein TcasGA2_TC015132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96AY4 275 9.7e-24 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44058 BF_2 43.23 0.32 5927 642925926 XP_008194700.1 6390 0.0e+00 PREDICTED: tetratricopeptide repeat protein 28 [Tribolium castaneum] 347968281 XM_312278.5 861 0 Anopheles gambiae str. PEST AGAP002648-PA (AgaP_AGAP002648) mRNA, complete cds -- -- -- -- Q96AY4 3087 0.0e+00 Tetratricopeptide repeat protein 28 OS=Homo sapiens GN=TTC28 PE=1 SV=4 PF10579//PF07721//PF13181//PF10255//PF13371//PF13374//PF00515//PF13176//PF07544//PF13414 Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Tetratricopeptide repeat//RNA polymerase I-associated factor PAF67//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//RNA polymerase II transcription mediator complex subunit 9//TPR repeat GO:0006357//GO:0006446//GO:0007268 regulation of transcription from RNA polymerase II promoter//regulation of translational initiation//synaptic transmission GO:0043495//GO:0003743//GO:0001104//GO:0033130//GO:0042802//GO:0005515 protein anchor//translation initiation factor activity//RNA polymerase II transcription cofactor activity//acetylcholine receptor binding//identical protein binding//protein binding GO:0005840//GO:0005737//GO:0005852//GO:0016592 ribosome//cytoplasm//eukaryotic translation initiation factor 3 complex//mediator complex KOG0548 Molecular co-chaperone STI1 Cluster-8309.44059 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44060 BF_2 649.10 9.16 3250 546683908 ERL93656.1 2922 0.0e+00 hypothetical protein D910_10944 [Dendroctonus ponderosae] 195130912 XM_002009859.1 179 4.598e-86 Drosophila mojavensis GI14989 (Dmoj\GI14989), mRNA -- -- -- -- Q80XJ3 846 6.9e-89 Tetratricopeptide repeat protein 28 OS=Mus musculus GN=Ttc28 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44063 BF_2 73.61 0.90 3722 649572255 NP_001280540.1 1336 2.9e-144 FMRFamide receptor [Tribolium castaneum]>gi|91078222|ref|XP_969392.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915085|ref|XP_008190406.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915087|ref|XP_008190407.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|270002872|gb|EEZ99319.1| hypothetical protein TcasGA2_TC001381 [Tribolium castaneum]>gi|485836781|tpg|DAA64478.1| TPA_inf: FMRFamide-like G protein-coupled receptor [Tribolium castaneum] 158301538 XM_321207.2 76 9.53812e-29 Anopheles gambiae str. PEST AGAP001862-PA (GPRNNA1) mRNA, complete cds -- -- -- -- Q9VZW5 891 4.8e-94 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.44064 BF_2 74.77 0.96 3559 649572255 NP_001280540.1 1336 2.8e-144 FMRFamide receptor [Tribolium castaneum]>gi|91078222|ref|XP_969392.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915085|ref|XP_008190406.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|642915087|ref|XP_008190407.1| PREDICTED: FMRFamide receptor [Tribolium castaneum]>gi|270002872|gb|EEZ99319.1| hypothetical protein TcasGA2_TC001381 [Tribolium castaneum]>gi|485836781|tpg|DAA64478.1| TPA_inf: FMRFamide-like G protein-coupled receptor [Tribolium castaneum] 158301538 XM_321207.2 76 9.11633e-29 Anopheles gambiae str. PEST AGAP001862-PA (GPRNNA1) mRNA, complete cds -- -- -- -- Q9VZW5 891 4.6e-94 FMRFamide receptor OS=Drosophila melanogaster GN=FR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.44069 BF_2 486.74 5.20 4206 642933107 XP_008197261.1 1670 6.2e-183 PREDICTED: prominin-like protein isoform X1 [Tribolium castaneum]>gi|270011437|gb|EFA07885.1| hypothetical protein TcasGA2_TC005459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82295 530 3.9e-52 Prominin-like protein OS=Drosophila melanogaster GN=CG7740 PE=1 SV=1 PF04513//PF13903//PF07464//PF02417//PF07926//PF05356//PF05478//PF01442 Baculovirus polyhedron envelope protein, PEP, C terminus//PMP-22/EMP/MP20/Claudin tight junction//Apolipophorin-III precursor (apoLp-III)//Chromate transporter//TPR/MLP1/MLP2-like protein//Phage Coat protein B//Prominin//Apolipoprotein A1/A4/E domain GO:0006606//GO:0042157//GO:0015703//GO:0006869 protein import into nucleus//lipoprotein metabolic process//chromate transport//lipid transport GO:0015109//GO:0008289//GO:0005198 chromate transmembrane transporter activity//lipid binding//structural molecule activity GO:0005576//GO:0016021//GO:0019028//GO:0019031 extracellular region//integral component of membrane//viral capsid//viral envelope KOG4331 Polytopic membrane protein Prominin Cluster-8309.44071 BF_2 36.93 0.86 2089 642915964 XP_008190829.1 1006 3.0e-106 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 1.3e-27 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44072 BF_2 193.28 6.77 1481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0003677//GO:0046983 DNA binding//protein dimerization activity -- -- -- -- Cluster-8309.44073 BF_2 30.06 0.57 2490 795011494 XP_011872774.1 366 5.9e-32 PREDICTED: uncharacterized protein LOC105564750, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.44075 BF_2 1344.46 61.68 1199 91093479 XP_968090.1 424 5.3e-39 PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930712|ref|XP_008199997.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930714|ref|XP_008199998.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930716|ref|XP_008199999.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930718|ref|XP_008200000.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|270012666|gb|EFA09114.1| hypothetical protein TcasGA2_TC015974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.44076 BF_2 1263.41 12.54 4501 91087363 XP_975631.1 632 1.5e-62 PREDICTED: iron-sulfur cluster assembly enzyme ISCU, mitochondrial [Tribolium castaneum]>gi|270010618|gb|EFA07066.1| hypothetical protein TcasGA2_TC010045 [Tribolium castaneum] 844835377 XM_012936598.1 119 1.44265e-52 Schistosoma haematobium Iron-sulfur cluster assembly enzyme ISCU, mitochondrial mRNA K04488 iscU, nifU nitrogen fixation protein NifU and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K04488 Q9D7P6 568 1.6e-56 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial OS=Mus musculus GN=Iscu PE=1 SV=1 PF09494//PF01592//PF05735 Slx4 endonuclease//NifU-like N terminal domain//Thrombospondin C-terminal region GO:0016226//GO:0006281//GO:0006260//GO:0007155//GO:0006308 iron-sulfur cluster assembly//DNA repair//DNA replication//cell adhesion//DNA catabolic process GO:0017108//GO:0051536//GO:0005509//GO:0005506 5'-flap endonuclease activity//iron-sulfur cluster binding//calcium ion binding//iron ion binding GO:0005634//GO:0005576//GO:0033557 nucleus//extracellular region//Slx1-Slx4 complex KOG3361 Iron binding protein involved in Fe-S cluster formation Cluster-8309.44077 BF_2 626.11 25.16 1328 91093479 XP_968090.1 424 5.9e-39 PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930712|ref|XP_008199997.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930714|ref|XP_008199998.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930716|ref|XP_008199999.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|642930718|ref|XP_008200000.1| PREDICTED: uncharacterized protein LOC656468 [Tribolium castaneum]>gi|270012666|gb|EFA09114.1| hypothetical protein TcasGA2_TC015974 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular -- -- Cluster-8309.44080 BF_2 430.00 5.17 3768 642914430 XP_008201676.1 2675 1.6e-299 PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum]>gi|642914432|ref|XP_008201677.1| PREDICTED: semaphorin-2A isoform X2 [Tribolium castaneum] 642914431 XM_008203455.1 637 0 PREDICTED: Tribolium castaneum semaphorin-2A (LOC656741), transcript variant X3, mRNA -- -- -- -- Q9XZC8 2207 1.2e-246 Semaphorin-2A OS=Schistocerca gregaria GN=SEMA-2A PE=2 SV=1 PF01403//PF01437 Sema domain//Plexin repeat -- -- GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.44081 BF_2 11.19 0.48 1259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44082 BF_2 22.30 0.58 1907 478251538 ENN72000.1 1071 8.0e-114 hypothetical protein YQE_11291, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SWK7 184 2.4e-12 RING finger protein 145 OS=Mus musculus GN=Rnf145 PE=2 SV=1 PF00097//PF17123//PF12678//PF14634//PF12861//PF13639 Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.44083 BF_2 431.69 4.68 4146 282721016 NP_001164208.1 2480 7.2e-277 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 406 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2115 6.3e-236 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF15324//PF00400//PF12125//PF00646//PF12937//PF01557 Hedgehog signalling target//WD domain, G-beta repeat//D domain of beta-TrCP//F-box domain//F-box-like//Fumarylacetoacetate (FAA) hydrolase family GO:0008152//GO:0007224 metabolic process//smoothened signaling pathway GO:0046983//GO:0005515//GO:0003824 protein dimerization activity//protein binding//catalytic activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.44084 BF_2 168.36 1.16 6382 282721016 NP_001164208.1 2467 3.6e-275 supernumerary limbs [Tribolium castaneum] 170067177 XM_001868344.1 397 0 Culex quinquefasciatus F-box/WD repeat protein 11, mRNA K03362 FBXW1_11, BTRC, beta-TRCP F-box and WD-40 domain protein 1/11 http://www.genome.jp/dbget-bin/www_bget?ko:K03362 Q9Y297 2110 3.7e-235 F-box/WD repeat-containing protein 1A OS=Homo sapiens GN=BTRC PE=1 SV=1 PF15324//PF00400//PF12125//PF00646//PF12937//PF01557 Hedgehog signalling target//WD domain, G-beta repeat//D domain of beta-TrCP//F-box domain//F-box-like//Fumarylacetoacetate (FAA) hydrolase family GO:0007224//GO:0008152 smoothened signaling pathway//metabolic process GO:0046983//GO:0005515//GO:0003824 protein dimerization activity//protein binding//catalytic activity -- -- KOG0281 Beta-TrCP (transducin repeats containing)/Slimb proteins Cluster-8309.44085 BF_2 603.94 12.85 2253 642920207 XP_008192249.1 940 1.5e-98 PREDICTED: plancitoxin-1 [Tribolium castaneum] -- -- -- -- -- K01158 DNASE2 deoxyribonuclease II http://www.genome.jp/dbget-bin/www_bget?ko:K01158 Q75WF2 570 4.8e-57 Plancitoxin-1 OS=Acanthaster planci PE=1 SV=1 PF03265//PF15880 Deoxyribonuclease II//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial GO:0006259//GO:0006308 DNA metabolic process//DNA catabolic process GO:0004531 deoxyribonuclease II activity GO:0005739//GO:0005747 mitochondrion//mitochondrial respiratory chain complex I KOG3825 Deoxyribonuclease II Cluster-8309.44092 BF_2 1372.54 17.78 3517 642928441 XP_008193786.1 274 3.9e-21 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44093 BF_2 960.61 10.81 4004 189240839 XP_001812334.1 3167 0.0e+00 PREDICTED: SWI/SNF complex subunit SMARCC2 [Tribolium castaneum]>gi|270013718|gb|EFA10166.1| hypothetical protein TcasGA2_TC012356 [Tribolium castaneum] 585702584 XM_006897683.1 41 2.93678e-09 PREDICTED: Elephantulus edwardii SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (SMARCC2), mRNA K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q8TAQ2 1969 5.1e-219 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens GN=SMARCC2 PE=1 SV=1 PF04433//PF09268 SWIRM domain//Clathrin, heavy-chain linker GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005488//GO:0005515//GO:0005198 binding//protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle KOG1279 Chromatin remodeling factor subunit and related transcription factors Cluster-8309.44094 BF_2 28.90 0.31 4215 642939478 XP_008197026.1 1937 6.8e-214 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 724 1.3e-74 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF00854//PF06432//PF04923//PF07690 POT family//Phosphatidylinositol N-acetylglucosaminyltransferase//Ninjurin//Major Facilitator Superfamily GO:0007155//GO:0006506//GO:0042246//GO:0006810//GO:0055085 cell adhesion//GPI anchor biosynthetic process//tissue regeneration//transport//transmembrane transport GO:0005215//GO:0017176 transporter activity//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.44095 BF_2 185.01 2.34 3590 642924494 XP_008194318.1 1947 4.0e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 9.0e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.44097 BF_2 217.23 2.33 4184 642913457 XP_008201020.1 3978 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.2e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00023//PF00784//PF13606 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.44098 BF_2 202.66 2.21 4115 642913457 XP_008201020.1 4091 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.1e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF13606//PF00023//PF00784 Ankyrin repeat//Ankyrin repeat//MyTH4 domain -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.44103 BF_2 625.68 10.79 2712 642920316 XP_008192296.1 1643 5.4e-180 PREDICTED: histone-lysine N-methyltransferase setd3 [Tribolium castaneum] -- -- -- -- -- K19199 SETD3 histone-lysine N-methyltransferase SETD3 http://www.genome.jp/dbget-bin/www_bget?ko:K19199 Q5ZML9 864 4.7e-91 Histone-lysine N-methyltransferase setd3 OS=Gallus gallus GN=SETD3 PE=2 SV=1 PF00856//PF00253 SET domain//Ribosomal protein S14p/S29e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1337 N-methyltransferase Cluster-8309.44104 BF_2 7.43 0.69 740 91081763 XP_973188.1 468 2.6e-44 PREDICTED: UDP-glucuronosyltransferase 2B20 [Tribolium castaneum]>gi|270005052|gb|EFA01500.1| hypothetical protein TcasGA2_TC007056 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q88168 361 2.7e-33 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201//PF02419 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//PsbL protein GO:0008152//GO:0015979 metabolic process//photosynthesis GO:0016758//GO:0016740 transferase activity, transferring hexosyl groups//transferase activity GO:0009539//GO:0009523//GO:0016020 photosystem II reaction center//photosystem II//membrane -- -- Cluster-8309.44105 BF_2 1325.51 3.61 15640 189237595 XP_966729.2 2234 9.1e-248 PREDICTED: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [Tribolium castaneum] 642910996 XM_968304.3 334 1.52899e-171 PREDICTED: Tribolium castaneum single-stranded DNA-binding protein 3 (LOC662190), transcript variant X3, mRNA K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 P49071 1432 3.7e-156 MAP kinase-activated protein kinase 2 OS=Drosophila melanogaster GN=MAPk-Ak2 PE=2 SV=1 PF00155//PF08001//PF06016//PF01053//PF01212//PF06293//PF07714//PF09029//PF00069 Aminotransferase class I and II//CMV US//Reovirus core-spike protein lambda-2 (L2)//Cys/Met metabolism PLP-dependent enzyme//Beta-eliminating lyase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//5-aminolevulinate synthase presequence//Protein kinase domain GO:0006520//GO:0006544//GO:0006783//GO:0009451//GO:0030683//GO:0006370//GO:0009058//GO:0006566//GO:0006778//GO:0042967//GO:0006468//GO:0006563 cellular amino acid metabolic process//glycine metabolic process//heme biosynthetic process//RNA modification//evasion or tolerance by virus of host immune response//7-methylguanosine mRNA capping//biosynthetic process//threonine metabolic process//porphyrin-containing compound metabolic process//acyl-carrier-protein biosynthetic process//protein phosphorylation//L-serine metabolic process GO:0004672//GO:0016773//GO:0004484//GO:0003870//GO:0030170//GO:0004482//GO:0016829//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//mRNA guanylyltransferase activity//5-aminolevulinate synthase activity//pyridoxal phosphate binding//mRNA (guanine-N7-)-methyltransferase activity//lyase activity//ATP binding GO:0005759//GO:0016020//GO:0044386//GO:0019028 mitochondrial matrix//membrane//integral to host endoplasmic reticulum membrane//viral capsid KOG0604 MAP kinase-activated protein kinase 2 Cluster-8309.44106 BF_2 992.06 2.73 15492 189237595 XP_966729.2 2234 9.0e-248 PREDICTED: 5-aminolevulinate synthase, erythroid-specific, mitochondrial [Tribolium castaneum] 642910996 XM_968304.3 331 7.04623e-170 PREDICTED: Tribolium castaneum single-stranded DNA-binding protein 3 (LOC662190), transcript variant X3, mRNA K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 P49071 1432 3.7e-156 MAP kinase-activated protein kinase 2 OS=Drosophila melanogaster GN=MAPk-Ak2 PE=2 SV=1 PF00069//PF09029//PF07714//PF01212//PF01053//PF08001//PF06016//PF00155//PF06293 Protein kinase domain//5-aminolevulinate synthase presequence//Protein tyrosine kinase//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme//CMV US//Reovirus core-spike protein lambda-2 (L2)//Aminotransferase class I and II//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0042967//GO:0006468//GO:0006563//GO:0009058//GO:0006778//GO:0006566//GO:0006520//GO:0006783//GO:0006544//GO:0030683//GO:0009451//GO:0006370 acyl-carrier-protein biosynthetic process//protein phosphorylation//L-serine metabolic process//biosynthetic process//porphyrin-containing compound metabolic process//threonine metabolic process//cellular amino acid metabolic process//heme biosynthetic process//glycine metabolic process//evasion or tolerance by virus of host immune response//RNA modification//7-methylguanosine mRNA capping GO:0005524//GO:0016829//GO:0003870//GO:0004484//GO:0030170//GO:0004482//GO:0004672//GO:0016773 ATP binding//lyase activity//5-aminolevulinate synthase activity//mRNA guanylyltransferase activity//pyridoxal phosphate binding//mRNA (guanine-N7-)-methyltransferase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0019028//GO:0044386//GO:0005759//GO:0016020 viral capsid//integral to host endoplasmic reticulum membrane//mitochondrial matrix//membrane KOG0604 MAP kinase-activated protein kinase 2 Cluster-8309.44107 BF_2 27.91 2.48 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44108 BF_2 43.27 0.62 3213 -- -- -- -- -- 462302786 APGK01050086.1 56 1.07861e-17 Dendroctonus ponderosae Seq01050096, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44109 BF_2 3.69 0.63 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44112 BF_2 54.80 1.13 2307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00681 Plectin repeat -- -- -- -- GO:0005856 cytoskeleton -- -- Cluster-8309.44114 BF_2 307.93 2.00 6712 642929667 XP_008195928.1 3270 0.0e+00 PREDICTED: probable Rho GTPase-activating protein CG5521 isoform X1 [Tribolium castaneum] 642929668 XM_970393.2 238 1.52026e-118 PREDICTED: Tribolium castaneum probable Rho GTPase-activating protein CG5521 (LOC664386), transcript variant X2, mRNA -- -- -- -- Q9VB98 1597 1.2e-175 Probable Rho GTPase-activating protein CG5521 OS=Drosophila melanogaster GN=CG5521 PE=1 SV=2 PF03367//PF02145//PF00130//PF01155//PF04135//PF03110 ZPR1 zinc-finger domain//Rap/ran-GAP//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Nucleolar RNA-binding protein, Nop10p family//SBP domain GO:0035556//GO:0001522//GO:0042254//GO:0051056//GO:0006464 intracellular signal transduction//pseudouridine synthesis//ribosome biogenesis//regulation of small GTPase mediated signal transduction//cellular protein modification process GO:0008270//GO:0016151//GO:0030515//GO:0003677//GO:0005096 zinc ion binding//nickel cation binding//snoRNA binding//DNA binding//GTPase activator activity GO:0005634//GO:0072588 nucleus//box H/ACA RNP complex KOG2703 C4-type Zn-finger protein Cluster-8309.44117 BF_2 235.75 5.04 2245 642928504 XP_008193818.1 868 3.3e-90 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2K6 283 9.2e-24 Endoplasmic reticulum metallopeptidase 1 OS=Homo sapiens GN=ERMP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.44118 BF_2 48.77 0.31 6771 642924674 XP_008194391.1 1323 1.7e-142 PREDICTED: protein abrupt isoform X2 [Tribolium castaneum] 642924672 XM_969854.3 316 6.69544e-162 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X4, mRNA -- -- -- -- Q24174 657 1.2e-66 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF04135//PF13465//PF00096//PF00651//PF02892//PF13912 Nucleolar RNA-binding protein, Nop10p family//Zinc-finger double domain//Zinc finger, C2H2 type//BTB/POZ domain//BED zinc finger//C2H2-type zinc finger GO:0042254//GO:0001522 ribosome biogenesis//pseudouridine synthesis GO:0003677//GO:0030515//GO:0005515//GO:0046872 DNA binding//snoRNA binding//protein binding//metal ion binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.44119 BF_2 110.51 4.90 1231 478253914 ENN74206.1 988 2.2e-104 hypothetical protein YQE_09179, partial [Dendroctonus ponderosae]>gi|546674879|gb|ERL86165.1| hypothetical protein D910_03578 [Dendroctonus ponderosae] 780631737 XM_011687331.1 63 5.21717e-22 PREDICTED: Wasmannia auropunctata nicotinate phosphoribosyltransferase (LOC105448642), transcript variant X2, mRNA K00763 pncB, NAPRT1 nicotinate phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00763 Q9VQX4 803 2.5e-84 Nicotinate phosphoribosyltransferase OS=Drosophila melanogaster GN=CG3714 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2511 Nicotinic acid phosphoribosyltransferase Cluster-8309.44120 BF_2 213.02 2.66 3643 817051906 XP_012253468.1 1791 5.0e-197 PREDICTED: autophagy-related protein 16-1 isoform X2 [Athalia rosae] -- -- -- -- -- K17890 ATG16L autophagy-related protein 16, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17890 Q676U5 920 2.0e-97 Autophagy-related protein 16-1 OS=Homo sapiens GN=ATG16L1 PE=1 SV=2 PF08702//PF05837//PF00105//PF00400 Fibrinogen alpha/beta chain family//Centromere protein H (CENP-H)//Zinc finger, C4 type (two domains)//WD domain, G-beta repeat GO:0051258//GO:0051382//GO:0007165//GO:0030168//GO:0006355 protein polymerization//kinetochore assembly//signal transduction//platelet activation//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0005102//GO:0008270//GO:0030674//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//receptor binding//zinc ion binding//protein binding, bridging//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005577//GO:0000776 transcription factor complex//nucleus//fibrinogen complex//kinetochore KOG0288 WD40 repeat protein TipD Cluster-8309.44121 BF_2 32.96 0.41 3657 642922229 XP_008193071.1 838 1.6e-86 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] 642922228 XM_008194849.1 74 1.21208e-27 PREDICTED: Tribolium castaneum thiamine transporter 2-like (LOC661148), mRNA K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 Q22931 325 2.0e-28 Folate-like transporter 3 OS=Caenorhabditis elegans GN=folt-3 PE=3 SV=3 PF01770//PF07690 Reduced folate carrier//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.44122 BF_2 187.65 2.74 3156 642911928 XP_967929.2 2694 8.4e-302 PREDICTED: uncharacterized protein LOC656296 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60611 151 2.6e-08 DNA-binding protein SATB1 OS=Mus musculus GN=Satb1 PE=1 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG3755 SATB1 matrix attachment region binding protein Cluster-8309.44123 BF_2 315.00 2.75 5077 91091902 XP_971322.1 679 6.1e-68 PREDICTED: mediator of RNA polymerase II transcription subunit 22 [Tribolium castaneum]>gi|270000800|gb|EEZ97247.1| hypothetical protein TcasGA2_TC011045 [Tribolium castaneum] -- -- -- -- -- K15139 MED22 mediator of RNA polymerase II transcription subunit 22 http://www.genome.jp/dbget-bin/www_bget?ko:K15139 Q7QB45 538 5.6e-53 Mediator of RNA polymerase II transcription subunit 22 OS=Anopheles gambiae GN=MED22 PE=3 SV=3 PF00219//PF00093//PF14528//PF06179 Insulin-like growth factor binding protein//von Willebrand factor type C domain//LAGLIDADG-like domain//Surfeit locus protein 5 subunit 22 of Mediator complex GO:0006357//GO:0001558 regulation of transcription from RNA polymerase II promoter//regulation of cell growth GO:0001104//GO:0004519//GO:0005520//GO:0005515 RNA polymerase II transcription cofactor activity//endonuclease activity//insulin-like growth factor binding//protein binding GO:0005576//GO:0016592//GO:0016942 extracellular region//mediator complex//insulin-like growth factor binding protein complex KOG3304 Surfeit family protein 5 Cluster-8309.44124 BF_2 59.06 9.47 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44125 BF_2 141.58 1.32 4786 642925187 XP_008194461.1 3226 0.0e+00 PREDICTED: myelin regulatory factor isoform X2 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.36945e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1228 5.2e-133 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF05224//PF10152 NDT80 / PhoG like DNA-binding family//Predicted coiled-coil domain-containing protein (DUF2360) -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.44126 BF_2 119.29 0.62 8284 546680590 ERL90833.1 6072 0.0e+00 hypothetical protein D910_08178 [Dendroctonus ponderosae] 642925848 XM_008192328.1 61 4.65073e-20 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- Q6DFF9 2154 3.8e-240 Mitogen-activated protein kinase-binding protein 1 OS=Xenopus laevis GN=mapkbp1 PE=2 SV=1 PF00400//PF08367 WD domain, G-beta repeat//Peptidase M16C associated GO:0006508 proteolysis GO:0005515 protein binding -- -- KOG1408 WD40 repeat protein Cluster-8309.44127 BF_2 440.18 6.46 3137 91090830 XP_971933.1 783 3.3e-80 PREDICTED: ras-related protein M-Ras [Tribolium castaneum]>gi|642935926|ref|XP_008198232.1| PREDICTED: ras-related protein M-Ras [Tribolium castaneum]>gi|270013249|gb|EFA09697.1| hypothetical protein TcasGA2_TC011829 [Tribolium castaneum] 332376259 BT128312.1 188 4.40506e-91 Dendroctonus ponderosae clone DPO105_N17 unknown mRNA K07831 MRAS Ras-related protein M-Ras http://www.genome.jp/dbget-bin/www_bget?ko:K07831 O08989 639 6.7e-65 Ras-related protein M-Ras OS=Mus musculus GN=Mras PE=1 SV=1 PF03193//PF08477//PF01926//PF00071//PF02421//PF04670//PF00025 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ras family//Ferrous iron transport protein B//Gtr1/RagA G protein conserved region//ADP-ribosylation factor family GO:0015684//GO:0007264//GO:0006184 ferrous iron transport//small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0005525//GO:0003924//GO:0015093 GTP binding//GTPase activity//ferrous iron transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0395 Ras-related GTPase Cluster-8309.44129 BF_2 12.78 1.22 724 642929557 XP_008195884.1 854 4.4e-89 PREDICTED: focal adhesion kinase 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44132 BF_2 249.57 2.06 5364 270002048 EEZ98495.1 654 5.1e-65 hypothetical protein TcasGA2_TC000995 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44134 BF_2 650.38 6.40 4535 642913586 XP_008201074.1 1578 3.1e-172 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] 768311758 CP010986.1 104 3.1689e-44 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- PF02166 Androgen receptor GO:0030521//GO:0007165//GO:0006355 androgen receptor signaling pathway//signal transduction//regulation of transcription, DNA-templated GO:0004882//GO:0005496//GO:0003677 androgen receptor activity//steroid binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.44135 BF_2 27.85 0.73 1882 642913592 XP_008201077.1 367 3.4e-32 PREDICTED: dentin sialophosphoprotein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.44136 BF_2 354.91 7.82 2186 642913592 XP_008201077.1 1546 7.6e-169 PREDICTED: dentin sialophosphoprotein isoform X2 [Tribolium castaneum] 768311758 CP010986.1 104 1.51555e-44 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- PF02166 Androgen receptor GO:0007165//GO:0030521//GO:0006355 signal transduction//androgen receptor signaling pathway//regulation of transcription, DNA-templated GO:0004882//GO:0003677//GO:0005496 androgen receptor activity//DNA binding//steroid binding GO:0005634 nucleus -- -- Cluster-8309.44137 BF_2 10.65 0.86 804 642913586 XP_008201074.1 414 5.2e-38 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44138 BF_2 8.67 0.53 977 642913586 XP_008201074.1 369 1.0e-32 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] 768311758 CP010986.1 104 6.64626e-45 Verticillium dahliae VdLs.17 chromosome 7, complete sequence -- -- -- -- -- -- -- -- PF02166 Androgen receptor GO:0006355//GO:0007165//GO:0030521 regulation of transcription, DNA-templated//signal transduction//androgen receptor signaling pathway GO:0005496//GO:0003677//GO:0004882 steroid binding//DNA binding//androgen receptor activity GO:0005634 nucleus -- -- Cluster-8309.4414 BF_2 43.00 42.67 319 426376198 XP_004054894.1 448 2.3e-42 PREDICTED: uncharacterized protein LOC101140100 [Gorilla gorilla gorilla] 584613557 NG_033959.1 319 6.11965e-165 Homo sapiens poly (ADP-ribose) polymerase 2 (PARP2), RefSeqGene on chromosome 14 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44140 BF_2 24.42 1.38 1029 642913586 XP_008201074.1 465 8.0e-44 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44142 BF_2 37.69 2.30 974 642913586 XP_008201074.1 465 7.6e-44 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913588|ref|XP_008201075.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum]>gi|642913590|ref|XP_008201076.1| PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44145 BF_2 92.00 1.07 3886 91088515 XP_971706.1 1200 1.8e-128 PREDICTED: short-chain dehydrogenase/reductase family 16C member 6 [Tribolium castaneum] -- -- -- -- -- K15734 SDR16C5 all-trans-retinol dehydrogenase (NAD+) http://www.genome.jp/dbget-bin/www_bget?ko:K15734 A5PJJ7 506 2.2e-49 Short-chain dehydrogenase/reductase family 16C member 6 OS=Bos taurus GN=SDR16C6 PE=2 SV=1 PF02737//PF01209//PF01370//PF05175//PF13241//PF00899//PF03446//PF02882//PF01073//PF00106//PF02254//PF00208//PF03435//PF01210//PF02558//PF03721//PF02826//PF00056 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//ubiE/COQ5 methyltransferase family//NAD dependent epimerase/dehydratase family//Methyltransferase small domain//Putative NAD(P)-binding//ThiF family//NAD binding domain of 6-phosphogluconate dehydrogenase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//TrkA-N domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Saccharopine dehydrogenase NADP binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//Ketopantoate reductase PanE/ApbA//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//lactate/malate dehydrogenase, NAD binding domain GO:0008210//GO:0046168//GO:0006633//GO:0006098//GO:0018874//GO:0008152//GO:0019354//GO:0006552//GO:0046487//GO:0006554//GO:0006779//GO:0055114//GO:0008207//GO:0006568//GO:0006813//GO:0006520//GO:0006631//GO:0009396//GO:0006550//GO:0006574//GO:0015940//GO:0008209//GO:0006694//GO:0019521 estrogen metabolic process//glycerol-3-phosphate catabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//metabolic process//siroheme biosynthetic process//leucine catabolic process//glyoxylate metabolic process//lysine catabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process//tryptophan metabolic process//potassium ion transport//cellular amino acid metabolic process//fatty acid metabolic process//folic acid-containing compound biosynthetic process//isoleucine catabolic process//valine catabolic process//pantothenate biosynthetic process//androgen metabolic process//steroid biosynthetic process//D-gluconate metabolic process GO:0016491//GO:0043115//GO:0008677//GO:0004488//GO:0016616//GO:0003854//GO:0008168//GO:0051287//GO:0003824//GO:0008641//GO:0050662//GO:0003857//GO:0004616 oxidoreductase activity//precorrin-2 dehydrogenase activity//2-dehydropantoate 2-reductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//methyltransferase activity//NAD binding//catalytic activity//small protein activating enzyme activity//coenzyme binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG1201 Hydroxysteroid 17-beta dehydrogenase 11 Cluster-8309.44146 BF_2 1029.60 24.13 2072 91090840 XP_972191.1 1205 2.5e-129 PREDICTED: N-acetyl-D-glucosamine kinase [Tribolium castaneum]>gi|270013990|gb|EFA10438.1| hypothetical protein TcasGA2_TC012681 [Tribolium castaneum] -- -- -- -- -- K00884 NAGK, nagK N-acetylglucosamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00884 Q9QZ08 717 4.0e-74 N-acetyl-D-glucosamine kinase OS=Mus musculus GN=Nagk PE=2 SV=3 -- -- -- -- -- -- -- -- KOG1794 N-Acetylglucosamine kinase Cluster-8309.44147 BF_2 61.49 2.69 1245 170028341 XP_001842054.1 206 1.0e-13 conserved hypothetical protein [Culex quinquefasciatus]>gi|167874209|gb|EDS37592.1| conserved hypothetical protein [Culex quinquefasciatus] 759058842 XM_011340371.1 42 2.49072e-10 PREDICTED: Cerapachys biroi uncharacterized LOC105280125 (LOC105280125), mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44148 BF_2 6.56 0.31 1187 645020575 XP_003426678.2 386 1.3e-34 PREDICTED: uncharacterized protein LOC100123516 isoform X1 [Nasonia vitripennis] 749773866 XM_011143969.1 77 8.29086e-30 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X1, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44151 BF_2 10.00 1.44 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44153 BF_2 330.92 2.83 5181 91091502 XP_968873.1 1269 2.4e-136 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270000935|gb|EEZ97382.1| hypothetical protein TcasGA2_TC011207 [Tribolium castaneum] -- -- -- -- -- K05605 HIBCH 3-hydroxyisobutyryl-CoA hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K05605 A2VDC2 912 2.4e-96 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Xenopus laevis GN=hibch PE=2 SV=1 PF00378//PF16113 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0016836//GO:0003824 hydro-lyase activity//catalytic activity -- -- KOG1684 Enoyl-CoA hydratase Cluster-8309.44156 BF_2 323.88 2.58 5540 91091502 XP_968873.1 1272 1.1e-136 PREDICTED: 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270000935|gb|EEZ97382.1| hypothetical protein TcasGA2_TC011207 [Tribolium castaneum] -- -- -- -- -- K05605 HIBCH 3-hydroxyisobutyryl-CoA hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K05605 A2VDC2 912 2.6e-96 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial OS=Xenopus laevis GN=hibch PE=2 SV=1 PF16113//PF00378 Enoyl-CoA hydratase/isomerase//Enoyl-CoA hydratase/isomerase GO:0008152 metabolic process GO:0003824//GO:0016836 catalytic activity//hydro-lyase activity -- -- KOG1684 Enoyl-CoA hydratase Cluster-8309.44159 BF_2 125.76 8.29 922 270016206 EFA12652.1 326 9.5e-28 hypothetical protein TcasGA2_TC016253 [Tribolium castaneum] -- -- -- -- -- K08776 NPEPPS puromycin-sensitive aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K08776 Q9USX1 151 7.6e-09 Aminopeptidase 1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=ape1 PE=3 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.44160 BF_2 126.95 1.37 4151 642935247 XP_008197929.1 4314 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 726 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1681 1.3e-185 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF00041//PF16656//PF05506 Immunoglobulin domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Domain of unknown function (DUF756) GO:0016042//GO:0006771//GO:0019497//GO:0009395 lipid catabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//phospholipid catabolic process GO:0004629//GO:0046872//GO:0003993//GO:0005515 phospholipase C activity//metal ion binding//acid phosphatase activity//protein binding -- -- -- -- Cluster-8309.44163 BF_2 37.15 0.65 2682 270007047 EFA03495.1 1081 7.8e-115 hypothetical protein TcasGA2_TC013495 [Tribolium castaneum] -- -- -- -- -- K18695 GPCPD1 glycerophosphocholine phosphodiesterase GPCPD1 http://www.genome.jp/dbget-bin/www_bget?ko:K18695 Q9NPB8 481 1.2e-46 Glycerophosphocholine phosphodiesterase GPCPD1 OS=Homo sapiens GN=GPCPD1 PE=1 SV=2 PF01868//PF03009 Domain of unknown function UPF0086//Glycerophosphoryl diester phosphodiesterase family GO:0008033//GO:0051252//GO:0006364//GO:0006629//GO:0006379 tRNA processing//regulation of RNA metabolic process//rRNA processing//lipid metabolic process//mRNA cleavage GO:0008081//GO:0004540//GO:0003723 phosphoric diester hydrolase activity//ribonuclease activity//RNA binding GO:0000172//GO:0030677 ribonuclease MRP complex//ribonuclease P complex KOG2421 Predicted starch-binding protein Cluster-8309.44164 BF_2 313.00 219.42 341 167234390 NP_001107818.1 253 1.0e-19 adipokinetic hormone 2 precursor [Tribolium castaneum]>gi|81170844|gb|ABB58740.1| AKH-II preprohormone [Tribolium castaneum]>gi|126116534|gb|ABN79649.1| adipokinetic hormone 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17128 168 3.0e-11 Hypertrehalosaemic prohormone OS=Blaberus discoidalis PE=1 SV=1 PF06377//PF00711 Adipokinetic hormone//Beta defensin GO:0006952//GO:0007165 defense response//signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.44166 BF_2 230.08 2.53 4089 91076588 XP_968186.1 1366 1.1e-147 PREDICTED: transmembrane protein 194A [Tribolium castaneum]>gi|270002381|gb|EEZ98828.1| hypothetical protein TcasGA2_TC004435 [Tribolium castaneum] 642912650 XM_963240.2 181 4.48235e-87 PREDICTED: Tribolium castaneum charged multivesicular body protein 5 (LOC656734), mRNA K10391 TUBE tubulin epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K10391 Q9D6T1 783 1.8e-81 Tubulin epsilon chain OS=Mus musculus GN=Tube1 PE=2 SV=1 PF04632//PF04111//PF16326//PF05531//PF01920//PF04871//PF03357//PF00091//PF00462//PF07544 Fusaric acid resistance protein family//Autophagy protein Apg6//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//Prefoldin subunit//Uso1 / p115 like vesicle tethering protein, C terminal region//Snf7//Tubulin/FtsZ family, GTPase domain//Glutaredoxin//RNA polymerase II transcription mediator complex subunit 9 GO:0006457//GO:0045454//GO:0006914//GO:0006810//GO:0006886//GO:0006357//GO:0006118//GO:0007034//GO:0015031 protein folding//cell redox homeostasis//autophagy//transport//intracellular protein transport//regulation of transcription from RNA polymerase II promoter//obsolete electron transport//vacuolar transport//protein transport GO:0003677//GO:0001104//GO:0009055//GO:0015035//GO:0003924//GO:0051082//GO:0008565 DNA binding//RNA polymerase II transcription cofactor activity//electron carrier activity//protein disulfide oxidoreductase activity//GTPase activity//unfolded protein binding//protein transporter activity GO:0016592//GO:0005886//GO:0016020//GO:0019028//GO:0016272//GO:0005737 mediator complex//plasma membrane//membrane//viral capsid//prefoldin complex//cytoplasm KOG3817 Uncharacterized conserved protein Cluster-8309.44170 BF_2 923.29 8.04 5090 91078490 XP_968588.1 2030 1.3e-224 PREDICTED: COP9 signalosome complex subunit 1 [Tribolium castaneum]>gi|270004016|gb|EFA00464.1| hypothetical protein TcasGA2_TC003322 [Tribolium castaneum] 642915516 XM_963495.3 360 0 PREDICTED: Tribolium castaneum COP9 signalosome complex subunit 1 (LOC657006), mRNA K12175 GPS1, COPS1, CSN1 COP9 signalosome complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12175 Q99LD4 1580 8.4e-174 COP9 signalosome complex subunit 1 OS=Mus musculus GN=Gps1 PE=1 SV=1 PF13414//PF01399//PF00515 TPR repeat//PCI domain//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0686 COP9 signalosome, subunit CSN1 Cluster-8309.44173 BF_2 98.71 2.43 1984 478254217 ENN74482.1 310 1.5e-25 hypothetical protein YQE_08928, partial [Dendroctonus ponderosae]>gi|546675251|gb|ERL86487.1| hypothetical protein D910_03891 [Dendroctonus ponderosae] -- -- -- -- -- K04636 GNA14 guanine nucleotide-binding protein subunit alpha-14 http://www.genome.jp/dbget-bin/www_bget?ko:K04636 P23625 270 2.6e-22 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.44174 BF_2 46.31 0.46 4462 478265842 ENN82601.1 273 6.4e-21 hypothetical protein YQE_01027, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01442//PF02734 Apolipoprotein A1/A4/E domain//DAK2 domain GO:0006869//GO:0006071//GO:0046486//GO:0042157 lipid transport//glycerol metabolic process//glycerolipid metabolic process//lipoprotein metabolic process GO:0004371//GO:0008289 glycerone kinase activity//lipid binding GO:0005576 extracellular region -- -- Cluster-8309.44175 BF_2 141.00 3.06 2213 642919975 XP_008192152.1 1092 3.4e-116 PREDICTED: parathyroid hormone/parathyroid hormone-related peptide receptor-like [Tribolium castaneum]>gi|642919977|ref|XP_008192153.1| PREDICTED: parathyroid hormone/parathyroid hormone-related peptide receptor-like [Tribolium castaneum]>gi|270006438|gb|EFA02886.1| hypothetical protein TcasGA2_TC008110 [Tribolium castaneum]>gi|570932719|gb|AHF20216.1| parathyroid hormone receptor like 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P43220 492 5.3e-48 Glucagon-like peptide 1 receptor OS=Homo sapiens GN=GLP1R PE=1 SV=2 PF00002//PF02793 7 transmembrane receptor (Secretin family)//Hormone receptor domain GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0004871//GO:0004930 signal transducer activity//G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.44183 BF_2 32.46 0.60 2537 546685044 ERL94598.1 1467 1.3e-159 hypothetical protein D910_11875 [Dendroctonus ponderosae] 126142258 EF387104.1 128 8.02953e-58 Drosophila simulans strain S132 Malic DH (Mdh) gene, partial sequence K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P06801 1037 3.8e-111 NADP-dependent malic enzyme OS=Mus musculus GN=Me1 PE=1 SV=2 PF03949//PF00390//PF01420 Malic enzyme, NAD binding domain//Malic enzyme, N-terminal domain//Type I restriction modification DNA specificity domain GO:0006099//GO:0015976//GO:0006090//GO:0055114//GO:0006108//GO:0006304 tricarboxylic acid cycle//carbon utilization//pyruvate metabolic process//oxidation-reduction process//malate metabolic process//DNA modification GO:0004471//GO:0003677//GO:0051287 malate dehydrogenase (decarboxylating) (NAD+) activity//DNA binding//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.44185 BF_2 827.98 6.65 5492 642913045 XP_008201364.1 6843 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] 642913044 XM_008203142.1 708 0 PREDICTED: Tribolium castaneum fibrillin-2 (LOC663193), mRNA -- -- -- -- Q61555 3664 0.0e+00 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.44187 BF_2 1261.75 12.85 4394 270010422 EFA06870.1 1347 1.8e-145 hypothetical protein TcasGA2_TC009815 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.44188 BF_2 91.98 1.70 2552 637366323 XP_008121191.1 428 3.9e-39 PREDICTED: oocyte zinc finger protein XlCOF6-like, partial [Anolis carolinensis] 195570403 XM_002103161.1 88 1.39048e-35 Drosophila simulans GD19093 (Dsim\GD19093), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NQZ8 410 2.0e-38 Endothelial zinc finger protein induced by tumor necrosis factor alpha OS=Homo sapiens GN=ZNF71 PE=2 SV=1 PF00096//PF13465//PF13912//PF07776//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.44189 BF_2 25.63 0.40 2978 91093211 XP_969739.1 468 1.0e-43 PREDICTED: probable small nuclear ribonucleoprotein Sm D1 [Tribolium castaneum]>gi|270016480|gb|EFA12926.1| hypothetical protein TcasGA2_TC010472 [Tribolium castaneum] -- -- -- -- -- K11087 SNRPD1, SMD1 small nuclear ribonucleoprotein D1 http://www.genome.jp/dbget-bin/www_bget?ko:K11087 Q9VU02 423 7.1e-40 Probable small nuclear ribonucleoprotein Sm D1 OS=Drosophila melanogaster GN=SmD1 PE=1 SV=1 PF11095 Gem-associated protein 7 (Gemin7) -- -- -- -- GO:0032797 SMN complex KOG3428 Small nuclear ribonucleoprotein SMD1 and related snRNPs Cluster-8309.44193 BF_2 3.00 0.41 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44195 BF_2 164.27 2.92 2638 642933468 XP_973513.2 1225 1.5e-131 PREDICTED: homogentisate 1,2-dioxygenase [Tribolium castaneum] 685830398 LN609529.1 94 6.64314e-39 Strongyloides ratti genome assembly S_ratti_ED321 ,chromosome : 2 K00451 HGD, hmgA homogentisate 1,2-dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00451 O09173 1095 7.5e-118 Homogentisate 1,2-dioxygenase OS=Mus musculus GN=Hgd PE=1 SV=2 PF04209 homogentisate 1,2-dioxygenase GO:0055114//GO:0042207//GO:0006570//GO:0006559 oxidation-reduction process//styrene catabolic process//tyrosine metabolic process//L-phenylalanine catabolic process GO:0004411 homogentisate 1,2-dioxygenase activity -- -- KOG1417 Homogentisate 1,2-dioxygenase Cluster-8309.44196 BF_2 69.00 3.67 1073 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11081//PF07809 Protein of unknown function (DUF2890)//RTP801 C-terminal region GO:0009968//GO:0016032 negative regulation of signal transduction//viral process -- -- GO:0005737 cytoplasm -- -- Cluster-8309.44197 BF_2 268.71 3.40 3597 546675258 ERL86494.1 972 4.6e-102 hypothetical protein D910_03898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44198 BF_2 1795.66 35.82 2384 282165792 NP_001164135.1 870 2.0e-90 drongo protein isoform 2 [Tribolium castaneum]>gi|270008252|gb|EFA04700.1| drongo [Tribolium castaneum] -- -- -- -- -- K15044 AGFG1 Arf-GAP domain and FG repeats-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15044 P52594 415 4.8e-39 Arf-GAP domain and FG repeat-containing protein 1 OS=Homo sapiens GN=AGFG1 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0702 Predicted GTPase-activating protein Cluster-8309.44200 BF_2 6.45 0.35 1056 91079212 XP_966680.1 897 6.6e-94 PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|642916704|ref|XP_008192258.1| PREDICTED: myosin regulatory light chain sqh [Tribolium castaneum]>gi|270004989|gb|EFA01437.1| hypothetical protein TcasGA2_TC030667 [Tribolium castaneum] 665815702 XM_008558299.1 225 3.92634e-112 PREDICTED: Microplitis demolitor myosin regulatory light chain sqh (LOC103577593), mRNA K12755 MYL9 myosin regulatory light chain 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12755 P40423 847 1.7e-89 Myosin regulatory light chain sqh OS=Drosophila melanogaster GN=sqh PE=1 SV=1 PF10591//PF13833//PF00036//PF13405//PF13499//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0031 Myosin regulatory light chain, EF-Hand protein superfamily Cluster-8309.44204 BF_2 195.94 1.65 5254 642939784 XP_970158.2 1024 6.2e-108 PREDICTED: mesoderm induction early response protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T105 566 3.3e-56 Mesoderm induction early response protein 1 OS=Xenopus laevis GN=mier1 PE=2 SV=1 PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.44205 BF_2 473.50 6.52 3327 642919875 XP_008192105.1 3515 0.0e+00 PREDICTED: N-acetyltransferase 10 isoform X1 [Tribolium castaneum]>gi|270005385|gb|EFA01833.1| hypothetical protein TcasGA2_TC007435 [Tribolium castaneum] -- -- -- -- -- K14521 NAT10, KRE33 N-acetyltransferase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14521 Q8K224 2996 0.0e+00 N-acetyltransferase 10 OS=Mus musculus GN=Nat10 PE=2 SV=1 PF13718//PF13508//PF00583 GNAT acetyltransferase 2//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG2036 Predicted P-loop ATPase fused to an acetyltransferase Cluster-8309.44212 BF_2 25.31 3.84 563 642930844 XP_008196110.1 150 1.5e-07 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44214 BF_2 98.72 0.58 7416 270006156 EFA02604.1 2074 1.5e-229 hypothetical protein TcasGA2_TC008323 [Tribolium castaneum] 820858958 XM_012490996.1 144 3.0184e-66 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7RTS6 149 1.0e-07 Otopetrin-2 OS=Homo sapiens GN=OTOP2 PE=2 SV=3 PF01769//PF01499 Divalent cation transporter//Herpesvirus UL25 family GO:0006812//GO:0019072 cation transport//viral genome packaging GO:0008324 cation transmembrane transporter activity GO:0042025 host cell nucleus KOG4740 Uncharacterized conserved protein Cluster-8309.44216 BF_2 75.87 2.27 1684 642921007 XP_008192651.1 1341 3.5e-145 PREDICTED: uncharacterized protein LOC663563 isoform X6 [Tribolium castaneum] 820858958 XM_012490996.1 144 6.74952e-67 PREDICTED: Apis florea uncharacterized LOC100869561 (LOC100869561), mRNA -- -- -- -- Q7M734 135 1.0e-06 Otopetrin-1 OS=Rattus norvegicus GN=Otop1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44217 BF_2 67.00 0.65 4575 91080859 XP_976120.1 630 2.6e-62 PREDICTED: lipid storage droplets surface-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270005933|gb|EFA02381.1| hypothetical protein TcasGA2_TC008057 [Tribolium castaneum] -- -- -- -- -- K17284 PLIN2, ADRP perilipin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K17284 Q9VCI3 205 2.1e-14 Lipid storage droplets surface-binding protein 1 OS=Drosophila melanogaster GN=Lsd-1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44218 BF_2 443.00 3.31 5880 91087589 XP_971974.1 2420 9.3e-270 PREDICTED: RNA polymerase II subunit A C-terminal domain phosphatase [Tribolium castaneum]>gi|270010700|gb|EFA07148.1| hypothetical protein TcasGA2_TC010139 [Tribolium castaneum] -- -- -- -- -- K15732 CTDP1, FCP1 RNA polymerase II subunit A C-terminal domain phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K15732 Q7TSG2 708 1.3e-72 RNA polymerase II subunit A C-terminal domain phosphatase OS=Mus musculus GN=Ctdp1 PE=1 SV=1 PF02932//PF00366 Neurotransmitter-gated ion-channel transmembrane region//Ribosomal protein S17 GO:0042254//GO:0006811//GO:0006412 ribosome biogenesis//ion transport//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular KOG0323 TFIIF-interacting CTD phosphatases, including NLI-interacting factor Cluster-8309.44219 BF_2 88.43 3.04 1506 642913680 XP_008201115.1 852 1.6e-88 PREDICTED: protein amalgam-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01411//PF13895 tRNA synthetases class II (A)//Immunoglobulin domain GO:0006522//GO:0006419//GO:0006531 alanine metabolic process//alanyl-tRNA aminoacylation//aspartate metabolic process GO:0005524//GO:0000166//GO:0005515//GO:0004813 ATP binding//nucleotide binding//protein binding//alanine-tRNA ligase activity -- -- -- -- Cluster-8309.44220 BF_2 15.98 4.48 436 478255706 ENN75917.1 293 3.0e-24 hypothetical protein YQE_07558, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44224 BF_2 31.89 1.36 1265 91086881 XP_970132.1 1278 5.3e-138 PREDICTED: RING finger protein 113A [Tribolium castaneum]>gi|270010474|gb|EFA06922.1| hypothetical protein TcasGA2_TC009871 [Tribolium castaneum] 195450055 XM_002072309.1 74 4.11854e-28 Drosophila willistoni GK22373 (Dwil\GK22373), mRNA K13127 RNF113A, CWC24 RING finger protein 113A http://www.genome.jp/dbget-bin/www_bget?ko:K13127 O15541 956 4.7e-102 RING finger protein 113A OS=Homo sapiens GN=RNF113A PE=1 SV=1 PF00642//PF03854//PF16685//PF07297//PF13639//PF14634//PF00097//PF11789 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//P-11 zinc finger//zinc RING finger of MSL2//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit GO:0009059 macromolecule biosynthetic process GO:0003723//GO:0061630//GO:0005515//GO:0008270//GO:0003676//GO:0046872 RNA binding//ubiquitin protein ligase activity//protein binding//zinc ion binding//nucleic acid binding//metal ion binding GO:0030176 integral component of endoplasmic reticulum membrane KOG1813 Predicted E3 ubiquitin ligase Cluster-8309.44226 BF_2 253.17 1.84 6046 642912875 XP_008201292.1 4806 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X9 [Tribolium castaneum]>gi|270001881|gb|EEZ98328.1| hypothetical protein TcasGA2_TC000782 [Tribolium castaneum] 642912874 XM_008203070.1 1390 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1836 2.1e-203 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00628//PF07649//PF00781//PF00076//PF00609//PF00130//PF00788 PHD-finger//C1-like domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain GO:0007165//GO:0009395//GO:0007205//GO:0035556//GO:0055114//GO:0046486 signal transduction//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//intracellular signal transduction//oxidation-reduction process//glycerolipid metabolic process GO:0005515//GO:0004143//GO:0047134//GO:0046872//GO:0000166//GO:0003676//GO:0016301 protein binding//diacylglycerol kinase activity//protein-disulfide reductase activity//metal ion binding//nucleotide binding//nucleic acid binding//kinase activity GO:0005622 intracellular KOG1169 Diacylglycerol kinase Cluster-8309.44227 BF_2 17.14 0.36 2295 642922662 XP_008193267.1 167 6.4e-09 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.44228 BF_2 35.46 0.48 3371 642922662 XP_008193267.1 1142 8.3e-122 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 845 9.4e-89 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0016491//GO:0020037//GO:0005488//GO:0016705 iron ion binding//oxidoreductase activity//heme binding//binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.44231 BF_2 47.12 0.45 4679 429327037 AFZ78847.1 288 1.2e-22 putative cysteine-rich protein 1 [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- P36201 235 7.0e-18 Cysteine-rich protein 2 OS=Rattus norvegicus GN=Crip2 PE=2 SV=1 PF02188 GoLoco motif -- -- GO:0030695 GTPase regulator activity -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.44232 BF_2 35.97 0.33 4844 546675277 ERL86513.1 2764 9.9e-310 hypothetical protein D910_03917 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PD19 1667 6.5e-184 UPF0668 protein C10orf76 homolog OS=Mus musculus PE=2 SV=2 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- KOG4654 Uncharacterized conserved protein Cluster-8309.44234 BF_2 319.23 1.72 8030 189236343 XP_975398.2 1765 1.1e-193 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X3 [Tribolium castaneum] 642919611 XM_008193717.1 100 9.41791e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.8e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF02257//PF01388//PF12031 RFX DNA-binding domain//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518) GO:0006338//GO:0006355 chromatin remodeling//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.44237 BF_2 1639.88 28.47 2697 642937018 XP_008198655.1 2482 2.7e-277 PREDICTED: neutral ceramidase-like [Tribolium castaneum] -- -- -- -- -- K12349 ASAH2 neutral ceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K12349 Q9VA70 1845 8.3e-205 Neutral ceramidase OS=Drosophila melanogaster GN=CDase PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2232 Ceramidases Cluster-8309.44238 BF_2 2.00 0.62 421 861589141 KMQ82656.1 196 5.1e-13 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF01047 Transposase//MarR family GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44240 BF_2 21.64 0.81 1403 607356391 EZA50914.1 232 1.1e-16 hypothetical protein X777_10741 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01047//PF01498 MarR family//Transposase GO:0015074//GO:0006313//GO:0006355 DNA integration//transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44242 BF_2 3256.86 53.41 2838 642919346 XP_008191834.1 1839 1.1e-202 PREDICTED: uncharacterized protein LOC662079 [Tribolium castaneum]>gi|270005802|gb|EFA02250.1| hypothetical protein TcasGA2_TC007913 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.44244 BF_2 47.00 0.71 3050 282403501 NP_001164148.1 269 1.3e-20 fumble isoform 3 [Tribolium castaneum]>gi|270002881|gb|EEZ99328.1| fumble [Tribolium castaneum] -- -- -- -- -- K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q8K4K6 219 3.3e-16 Pantothenate kinase 1 OS=Mus musculus GN=Pank1 PE=1 SV=1 PF03630//PF00325 Fumble//Bacterial regulatory proteins, crp family GO:0015937//GO:0006355//GO:0015940 coenzyme A biosynthetic process//regulation of transcription, DNA-templated//pantothenate biosynthetic process GO:0005524//GO:0004594//GO:0003677 ATP binding//pantothenate kinase activity//DNA binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.44246 BF_2 80.13 1.63 2338 642919917 XP_008192124.1 1050 2.7e-111 PREDICTED: transmembrane 7 superfamily member 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NS93 457 6.4e-44 Transmembrane 7 superfamily member 3 OS=Homo sapiens GN=TM7SF3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44252 BF_2 38.53 0.50 3502 642921967 XP_008192964.1 947 3.5e-99 PREDICTED: protein painting of fourth isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W123 294 7.6e-25 Protein painting of fourth OS=Drosophila melanogaster GN=Pof PE=1 SV=1 PF01757//PF00076 Acyltransferase family//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0016747//GO:0003676 transferase activity, transferring acyl groups other than amino-acyl groups//nucleic acid binding -- -- -- -- Cluster-8309.44254 BF_2 403.89 4.73 3861 642923462 XP_008193755.1 1023 6.0e-108 PREDICTED: forkhead box protein L2-like isoform X1 [Tribolium castaneum] 507561117 XM_004664203.1 146 1.20991e-67 PREDICTED: Jaculus jaculus forkhead box L2 (Foxl2), mRNA K09405 FOXL forkhead box protein L http://www.genome.jp/dbget-bin/www_bget?ko:K09405 O88470 395 1.6e-36 Forkhead box protein L2 OS=Mus musculus GN=Foxl2 PE=1 SV=2 PF00250//PF06070 Forkhead domain//Herpesvirus large structural phosphoprotein UL32 GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005198//GO:0043565 transcription factor activity, sequence-specific DNA binding//structural molecule activity//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44258 BF_2 97.61 0.36 11641 642920053 XP_008192184.1 1927 2.7e-212 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.93838e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.9e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF03822//PF08159//PF00583//PF13508//PF08445//PF03396//PF02297//PF00341//PF13673//PF00159 NAF domain//NUC153 domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Cytochrome oxidase c subunit VIb//PDGF/VEGF domain//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide GO:0006206//GO:0006144//GO:0008283//GO:0040007//GO:0006351//GO:0015992//GO:0042967//GO:0006123//GO:0007165//GO:0019083 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//cell proliferation//growth//transcription, DNA-templated//proton transport//acyl-carrier-protein biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//viral transcription GO:0004129//GO:0016747//GO:0008080//GO:0005179//GO:0008083//GO:0003677//GO:0003899 cytochrome-c oxidase activity//transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity//hormone activity//growth factor activity//DNA binding//DNA-directed RNA polymerase activity GO:0005576//GO:0016020//GO:0045277//GO:0005634//GO:0005730//GO:0005739 extracellular region//membrane//respiratory chain complex IV//nucleus//nucleolus//mitochondrion KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.44259 BF_2 65.20 1.29 2403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00681 Plectin repeat -- -- -- -- GO:0005856 cytoskeleton -- -- Cluster-8309.44260 BF_2 91.94 1.53 2800 270007326 EFA03774.1 1530 7.0e-167 hypothetical protein TcasGA2_TC013885 [Tribolium castaneum] -- -- -- -- -- K12591 RRP6, EXOSC10 exosome complex exonuclease RRP6 http://www.genome.jp/dbget-bin/www_bget?ko:K12591 Q01780 843 1.3e-88 Exosome component 10 OS=Homo sapiens GN=EXOSC10 PE=1 SV=2 PF08066//PF02456//PF01612 PMC2NT (NUC016) domain//Adenovirus IVa2 protein//3'-5' exonuclease GO:0006139//GO:0006396//GO:0019083 nucleobase-containing compound metabolic process//RNA processing//viral transcription GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity GO:0000176 nuclear exosome (RNase complex) KOG2206 Exosome 3'-5' exoribonuclease complex, subunit PM/SCL-100 (Rrp6) Cluster-8309.44261 BF_2 517.72 8.37 2874 91094369 XP_970631.1 1029 8.9e-109 PREDICTED: E3 ubiquitin-protein ligase znrf1 [Tribolium castaneum] -- -- -- -- -- K10694 ZNRF1_2 E3 ubiquitin-protein ligase ZNRF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10694 Q71FD5 435 2.8e-41 E3 ubiquitin-protein ligase ZNRF2 OS=Mus musculus GN=Znrf2 PE=1 SV=1 PF13639//PF01612//PF15926//PF14634//PF12678//PF12906//PF17123//PF00097 Ring finger domain//3'-5' exonuclease//E3 ubiquitin-protein ligase RNF220//zinc-RING finger domain//RING-H2 zinc finger//RING-variant domain//RING-like zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0006139//GO:0090263 protein ubiquitination//nucleobase-containing compound metabolic process//positive regulation of canonical Wnt signaling pathway GO:0005515//GO:0046872//GO:0008270//GO:0003676//GO:0008408 protein binding//metal ion binding//zinc ion binding//nucleic acid binding//3'-5' exonuclease activity -- -- KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.44264 BF_2 782.47 8.32 4219 642922624 XP_008193254.1 3643 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] 642922625 XM_008195033.1 226 4.46534e-112 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07291 Methylamine utilisation protein MauE GO:0030416 methylamine metabolic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.44265 BF_2 85.33 0.88 4325 -- -- -- -- -- 642922625 XM_008195033.1 61 2.41945e-20 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF08001 CMV US GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0044386 integral to host endoplasmic reticulum membrane -- -- Cluster-8309.44266 BF_2 25.14 0.31 3680 642933135 XP_973578.2 3446 0.0e+00 PREDICTED: DNA topoisomerase 3-alpha [Tribolium castaneum] 571572814 XM_394050.5 155 1.14453e-72 PREDICTED: Apis mellifera DNA topoisomerase 3-alpha-like (LOC410571), mRNA K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 Q9NG98 2222 2.2e-248 DNA topoisomerase 3-alpha OS=Drosophila melanogaster GN=Top3alpha PE=2 SV=2 PF06839//PF01022//PF00556//PF01131//PF01396 GRF zinc finger//Bacterial regulatory protein, arsR family//Antenna complex alpha/beta subunit//DNA topoisomerase//Topoisomerase DNA binding C4 zinc finger GO:0019684//GO:0006265//GO:0006118//GO:0006355 photosynthesis, light reaction//DNA topological change//obsolete electron transport//regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0003916//GO:0045156//GO:0003677 transcription factor activity, sequence-specific DNA binding//zinc ion binding//DNA topoisomerase activity//electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//DNA binding GO:0005694//GO:0005667//GO:0030077//GO:0016021 chromosome//transcription factor complex//plasma membrane light-harvesting complex//integral component of membrane KOG1956 DNA topoisomerase III alpha Cluster-8309.44271 BF_2 154.97 1.20 5672 270009170 EFA05618.1 2269 2.9e-252 hypothetical protein TcasGA2_TC015826 [Tribolium castaneum] 768423227 XM_011554208.1 242 7.67338e-121 PREDICTED: Plutella xylostella histone-lysine N-methyltransferase SETD1-like (LOC105384048), mRNA K11422 SETD1, SET1 histone-lysine N-methyltransferase SETD1 http://www.genome.jp/dbget-bin/www_bget?ko:K11422 Q5LJZ2 1105 1.1e-118 Histone-lysine N-methyltransferase SETD1 OS=Drosophila melanogaster GN=Set1 PE=1 SV=1 PF00856//PF00076//PF03490 SET domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396//GO:0005515//GO:0003676 glycosylphosphatidylinositol diacylglycerol-lyase activity//protein binding//nucleic acid binding -- -- KOG1080 Histone H3 (Lys4) methyltransferase complex, subunit SET1 and related methyltransferases Cluster-8309.44275 BF_2 777.28 2.14 15482 642934437 XP_008197662.1 5528 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X1 [Tribolium castaneum]>gi|270013709|gb|EFA10157.1| hypothetical protein TcasGA2_TC012345 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.78095e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1577 5.7e-173 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00155//PF02178//PF13639//PF12125//PF00439//PF16866//PF00628//PF00202 Aminotransferase class I and II//AT hook motif//Ring finger domain//D domain of beta-TrCP//Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III GO:0009058 biosynthetic process GO:0003677//GO:0030170//GO:0046983//GO:0005515//GO:0008483//GO:0005488//GO:0008270 DNA binding//pyridoxal phosphate binding//protein dimerization activity//protein binding//transaminase activity//binding//zinc ion binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.44276 BF_2 1231.26 14.75 3778 646701548 KDR11217.1 3060 0.0e+00 E3 ubiquitin-protein ligase Nedd-4 [Zootermopsis nevadensis] -- -- -- -- -- K10591 NEDD4, RSP5 E3 ubiquitin-protein ligase NEDD4 http://www.genome.jp/dbget-bin/www_bget?ko:K10591 Q9VVI3 2157 7.7e-241 E3 ubiquitin-protein ligase Nedd-4 OS=Drosophila melanogaster GN=Nedd4 PE=1 SV=2 PF00632//PF00168//PF00397 HECT-domain (ubiquitin-transferase)//C2 domain//WW domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515 ubiquitin-protein transferase activity//protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.44279 BF_2 36.00 5.25 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44280 BF_2 34.64 1.25 1444 642928561 XP_008199958.1 648 6.8e-65 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 517 4.3e-51 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067//PF00640 Cytochrome P450//Phosphotyrosine interaction domain (PTB/PID) GO:0055114 oxidation-reduction process GO:0020037//GO:0005515//GO:0005506//GO:0016705 heme binding//protein binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.44281 BF_2 87.88 0.78 4977 642910291 XP_008198710.1 3584 0.0e+00 PREDICTED: guanine nucleotide exchange factor DBS-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63406 1738 3.9e-192 Guanine nucleotide exchange factor DBS OS=Rattus norvegicus GN=Mcf2l PE=1 SV=3 PF00435//PF00018//PF14604//PF00621//PF00806 Spectrin repeat//SH3 domain//Variant SH3 domain//RhoGEF domain//Pumilio-family RNA binding repeat GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089//GO:0003723 protein binding//Rho guanyl-nucleotide exchange factor activity//RNA binding -- -- -- -- Cluster-8309.44282 BF_2 224.99 2.61 3896 642910291 XP_008198710.1 1797 1.1e-197 PREDICTED: guanine nucleotide exchange factor DBS-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44283 BF_2 182.39 2.37 3512 270005700 EFA02148.1 294 1.8e-23 hypothetical protein TcasGA2_TC007800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15003//PF04625//PF09036//PF01484 HAUS augmin-like complex subunit 2//DEC-1 protein, N-terminal region//Bcr-Abl oncoprotein oligomerisation domain//Nematode cuticle collagen N-terminal domain GO:0007304//GO:0016310//GO:0006468//GO:0031023//GO:0009069//GO:0007165//GO:0051225 chorion-containing eggshell formation//phosphorylation//protein phosphorylation//microtubule organizing center organization//serine family amino acid metabolic process//signal transduction//spindle assembly GO:0004674//GO:0042302//GO:0005096//GO:0005213 protein serine/threonine kinase activity//structural constituent of cuticle//GTPase activator activity//structural constituent of chorion GO:0042600//GO:0005576 chorion//extracellular region -- -- Cluster-8309.44288 BF_2 82.00 2.18 1859 642923877 XP_008193910.1 439 1.5e-40 PREDICTED: aristaless isoform X1 [Tribolium castaneum] -- -- -- -- -- K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44289 BF_2 40.80 0.34 5302 189239596 XP_967754.2 1896 4.8e-209 PREDICTED: BTB/POZ domain-containing protein KCTD3 [Tribolium castaneum]>gi|270010663|gb|EFA07111.1| hypothetical protein TcasGA2_TC010101 [Tribolium castaneum] 170042981 XM_001849132.1 104 3.70915e-44 Culex quinquefasciatus BTB/POZ domain-containing protein KCTD3, mRNA -- -- -- -- Q8BFX3 921 2.3e-97 BTB/POZ domain-containing protein KCTD3 OS=Mus musculus GN=Kctd3 PE=2 SV=1 PF00651//PF09726//PF02214 BTB/POZ domain//Transmembrane protein//BTB/POZ domain GO:0051260 protein homooligomerization GO:0005515 protein binding GO:0016021 integral component of membrane KOG2714 SETA binding protein SB1 and related proteins, contain BTB/POZ domain Cluster-8309.44290 BF_2 616.47 4.26 6345 91078808 XP_970433.1 2223 7.0e-247 PREDICTED: protein SDA1 homolog [Tribolium castaneum]>gi|270004115|gb|EFA00563.1| hypothetical protein TcasGA2_TC003433 [Tribolium castaneum] -- -- -- -- -- K14856 SDA1, SDAD1 protein SDA1 http://www.genome.jp/dbget-bin/www_bget?ko:K14856 Q7KKH3 1747 4.5e-193 Protein SDA1 homolog OS=Drosophila melanogaster GN=Mys45A PE=1 SV=1 PF07690//PF06839//PF01306 Major Facilitator Superfamily//GRF zinc finger//LacY proton/sugar symporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0008270 zinc ion binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG2229 Protein required for actin cytoskeleton organization and cell cycle progression Cluster-8309.44293 BF_2 768.37 6.78 5028 642918835 XP_008191606.1 5206 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 6.18248e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- Q6ZUT9 2374 7.0e-266 DENN domain-containing protein 5B OS=Homo sapiens GN=DENND5B PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006269//GO:0006260//GO:0006351 DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated GO:0008270//GO:0005515//GO:0003896//GO:0003677 zinc ion binding//protein binding//DNA primase activity//DNA binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.44297 BF_2 36.45 0.55 3067 270000862 EEZ97309.1 900 8.7e-94 hypothetical protein TcasGA2_TC011118 [Tribolium castaneum] 195590478 XM_002084937.1 97 1.6621e-40 Drosophila simulans GD14552 (Dsim\GD14552), mRNA K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 P29747 388 8.4e-36 Cyclic AMP response element-binding protein A OS=Drosophila melanogaster GN=CrebA PE=1 SV=2 PF02183//PF07716//PF03131//PF07926//PF01544//PF00170//PF06005//PF04111 Homeobox associated leucine zipper//Basic region leucine zipper//bZIP Maf transcription factor//TPR/MLP1/MLP2-like protein//CorA-like Mg2+ transporter protein//bZIP transcription factor//Protein of unknown function (DUF904)//Autophagy protein Apg6 GO:0006914//GO:0030001//GO:0055085//GO:0000917//GO:0043093//GO:0006606//GO:0006355 autophagy//metal ion transport//transmembrane transport//barrier septum assembly//FtsZ-dependent cytokinesis//protein import into nucleus//regulation of transcription, DNA-templated GO:0003677//GO:0003700//GO:0043565//GO:0046873 DNA binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//metal ion transmembrane transporter activity GO:0005667//GO:0005634//GO:0005737//GO:0016020 transcription factor complex//nucleus//cytoplasm//membrane KOG0709 CREB/ATF family transcription factor Cluster-8309.44300 BF_2 98.00 1.40 3216 642931624 XP_008196660.1 331 8.7e-28 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF13465//PF00096//PF16622//PF02892//PF13912 Ring finger domain//Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0003677//GO:0008270//GO:0005515//GO:0046872 DNA binding//zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.44301 BF_2 36.20 0.32 5063 642929984 XP_008196053.1 1498 6.5e-163 PREDICTED: atrial natriuretic peptide receptor 1 [Tribolium castaneum] 642929983 XM_008197831.1 279 1.84986e-141 PREDICTED: Tribolium castaneum atrial natriuretic peptide receptor 1 (LOC664507), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18910 1051 1.8e-112 Atrial natriuretic peptide receptor 1 OS=Rattus norvegicus GN=Npr1 PE=1 SV=1 PF07714//PF00211//PF00069//PF06330//PF07701 Protein tyrosine kinase//Adenylate and Guanylate cyclase catalytic domain//Protein kinase domain//Trichodiene synthase (TRI5)//Heme NO binding associated GO:0009190//GO:0035556//GO:0006144//GO:0006468//GO:0016114//GO:0016106//GO:0046039//GO:0006182 cyclic nucleotide biosynthetic process//intracellular signal transduction//purine nucleobase metabolic process//protein phosphorylation//terpenoid biosynthetic process//sesquiterpenoid biosynthetic process//GTP metabolic process//cGMP biosynthetic process GO:0016849//GO:0045482//GO:0004672//GO:0004383//GO:0005524 phosphorus-oxygen lyase activity//trichodiene synthase activity//protein kinase activity//guanylate cyclase activity//ATP binding -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.44303 BF_2 855.82 10.51 3693 642934510 XP_008197694.1 3479 0.0e+00 PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|642934512|ref|XP_008197695.1| PREDICTED: AP-1 complex subunit gamma-1 isoform X2 [Tribolium castaneum]>gi|270013512|gb|EFA09960.1| hypothetical protein TcasGA2_TC012117 [Tribolium castaneum] 393809286 JQ824200.1 481 0 Bombyx mori adaptor protein complex-1 gamma subunit (AP1G) mRNA, complete cds, alternatively spliced K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 2321 7.2e-260 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF02883//PF02985//PF08367//PF01602 Adaptin C-terminal domain//HEAT repeat//Peptidase M16C associated//Adaptin N terminal region GO:0015031//GO:0006508//GO:0006886//GO:0016192 protein transport//proteolysis//intracellular protein transport//vesicle-mediated transport GO:0008565//GO:0005515 protein transporter activity//protein binding GO:0030117//GO:0044431//GO:0030131 membrane coat//Golgi apparatus part//clathrin adaptor complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.44304 BF_2 221.00 1.06 9025 642913467 XP_008201025.1 3247 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC664116 [Tribolium castaneum] 642913466 XM_008202803.1 409 0 PREDICTED: Tribolium castaneum uncharacterized LOC664116 (LOC664116), mRNA -- -- -- -- Q5BJU7 192 1.3e-12 Wiskott-Aldrich syndrome protein family member 1 OS=Rattus norvegicus GN=Wasf1 PE=1 SV=1 PF04013 Putative SAM-dependent RNA methyltransferase GO:0008033//GO:0009451 tRNA processing//RNA modification GO:0008175 tRNA methyltransferase activity -- -- KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.44306 BF_2 5.00 0.32 940 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44307 BF_2 26.65 0.35 3478 385845164 AFI81409.1 798 6.6e-82 lipoate protein ligase [Phyllotreta striolata] 385845163 JQ278008.1 57 3.24908e-18 Phyllotreta striolata lipoate protein ligase (lpl) mRNA, complete cds K10105 LIPT1 lipoyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10105 Q9Y234 412 1.6e-38 Lipoyltransferase 1, mitochondrial OS=Homo sapiens GN=LIPT1 PE=2 SV=1 PF08127//PF03099 Peptidase family C1 propeptide//Biotin/lipoate A/B protein ligase family GO:0050790//GO:0006464//GO:0006508 regulation of catalytic activity//cellular protein modification process//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3159 Lipoate-protein ligase A Cluster-8309.44308 BF_2 46.79 0.46 4540 478258212 ENN78341.1 2151 1.1e-238 hypothetical protein YQE_05143, partial [Dendroctonus ponderosae]>gi|546677008|gb|ERL87924.1| hypothetical protein D910_05312 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R7U0 1006 2.7e-107 Transmembrane channel-like protein 7 OS=Macaca fascicularis GN=TMC7 PE=2 SV=1 PF08686//PF07810 PLAC (protease and lacunin) domain//TMC domain -- -- GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.4431 BF_2 58.44 1.09 2527 642928107 XP_008200159.1 534 2.0e-51 PREDICTED: SAGA-associated factor 11 homolog [Tribolium castaneum]>gi|270010861|gb|EFA07309.1| hypothetical protein TcasGA2_TC015900 [Tribolium castaneum] -- -- -- -- -- K11363 SGF11 SAGA-associated factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11363 B0W8L4 238 1.7e-18 SAGA-associated factor 11 homolog OS=Culex quinquefasciatus GN=Sgf11 PE=3 SV=1 PF11522 Yeast phosphatidylinositol-4-OH kinase Pik1 -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.44310 BF_2 2288.18 23.82 4306 478261169 ENN80698.1 3064 0.0e+00 hypothetical protein YQE_02881, partial [Dendroctonus ponderosae] 549438548 KC282406.1 75 3.97404e-28 Leptinotarsa decemlineata clone 13-6555 heat shock protein mRNA, partial cds K09486 HYOU1 hypoxia up-regulated 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09486 Q9JKR6 1864 8.3e-207 Hypoxia up-regulated protein 1 OS=Mus musculus GN=Hyou1 PE=1 SV=1 PF06723 MreB/Mbl protein GO:0000902 cell morphogenesis -- -- -- -- KOG0104 Molecular chaperones GRP170/SIL1, HSP70 superfamily Cluster-8309.44312 BF_2 47.63 0.89 2538 91093831 XP_966868.1 430 2.3e-39 PREDICTED: proline-rich protein 4-like [Tribolium castaneum] 642938794 XM_961775.2 143 3.68477e-66 PREDICTED: Tribolium castaneum proline-rich protein 4-like (LOC657696), mRNA K01283 ACE peptidyl-dipeptidase A http://www.genome.jp/dbget-bin/www_bget?ko:K01283 Q9VLJ6 262 2.8e-21 Angiotensin-converting enzyme-related protein OS=Drosophila melanogaster GN=Acer PE=1 SV=1 PF00879//PF01401 Defensin propeptide//Angiotensin-converting enzyme GO:0006952//GO:0006508 defense response//proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane -- -- Cluster-8309.44314 BF_2 2.00 11.72 248 642915337 XP_008190578.1 215 1.9e-15 PREDICTED: fibrinogen C domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- K10104 FCN ficolin http://www.genome.jp/dbget-bin/www_bget?ko:K10104 A2AV25 148 4.5e-09 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44315 BF_2 253.64 4.17 2832 642933086 XP_008197254.1 1618 4.4e-177 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 1020 4.0e-109 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133//PF03171 Tubulin-tyrosine ligase family//2OG-Fe(II) oxygenase superfamily GO:0006464//GO:0055114 cellular protein modification process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.44319 BF_2 13.00 1.25 721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44322 BF_2 262.00 2.87 4108 642914043 XP_008201521.1 3397 0.0e+00 PREDICTED: metabotropic glutamate receptor 5-like [Tribolium castaneum]>gi|270002144|gb|EEZ98591.1| hypothetical protein TcasGA2_TC001106 [Tribolium castaneum] 852783725 XM_013028106.1 66 3.81667e-23 PREDICTED: Dipodomys ordii glutamate receptor, metabotropic 2 (Grm2), mRNA K04604 GRM5 metabotropic glutamate receptor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04604 P31424 2041 2.4e-227 Metabotropic glutamate receptor 5 OS=Rattus norvegicus GN=Grm5 PE=1 SV=2 PF01620//PF00003//PF02687//PF07562 Ribonuclease (pollen allergen)//7 transmembrane sweet-taste receptor of 3 GCPR//FtsX-like permease family//Nine Cysteines Domain of family 3 GPCR GO:0016068//GO:0007186 type I hypersensitivity//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020//GO:0005886 integral component of membrane//membrane//plasma membrane KOG1056 Glutamate-gated metabotropic ion channel receptor subunit GRM2 and related subunits, G-protein coupled receptor superfamily Cluster-8309.44323 BF_2 1492.60 7.05 9146 815898955 XP_012250113.1 3448 0.0e+00 PREDICTED: metabotropic glutamate receptor 2 isoform X2 [Bombus impatiens] 827545296 XM_004925338.2 134 1.34964e-60 PREDICTED: Bombyx mori metabotropic glutamate receptor 2-like (LOC101737989), mRNA K04611 MXR metabotropic X receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04611 O00222 1625 9.1e-179 Metabotropic glutamate receptor 8 OS=Homo sapiens GN=GRM8 PE=2 SV=2 PF00003//PF07690//PF09198//PF07562 7 transmembrane sweet-taste receptor of 3 GCPR//Major Facilitator Superfamily//Bacteriophage T4 beta-glucosyltransferase//Nine Cysteines Domain of family 3 GPCR GO:0006304//GO:0055085//GO:0007186 DNA modification//transmembrane transport//G-protein coupled receptor signaling pathway GO:0033821//GO:0004930 DNA beta-glucosyltransferase activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.44325 BF_2 9.16 0.98 679 270003075 EEZ99522.1 448 4.9e-42 hypothetical protein TcasGA2_TC000103 [Tribolium castaneum] 642916839 XM_008201303.1 165 5.59645e-79 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2B catalytic subunit 2-like (LOC657135), transcript variant X4, mRNA K04348 PPP3C, CNA serine/threonine-protein phosphatase 2B catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04348 Q27889 421 2.7e-40 Serine/threonine-protein phosphatase 2B catalytic subunit 2 OS=Drosophila melanogaster GN=Pp2B-14D PE=1 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG0375 Serine-threonine phosphatase 2B, catalytic subunit Cluster-8309.44326 BF_2 20.82 0.40 2472 189238013 XP_001813375.1 2647 1.9e-296 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 55 2.9767e-17 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1925 4.0e-214 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00664//PF13304//PF06414//PF00005//PF03193//PF00437 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//ABC transporter//Protein of unknown function, DUF258//Type II/IV secretion system protein GO:0006810//GO:0006200//GO:0055085 transport//obsolete ATP catabolic process//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.44327 BF_2 19.20 0.35 2562 189238013 XP_001813375.1 1776 1.9e-195 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 52 1.43607e-15 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1328 7.0e-145 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00437//PF13304//PF06414//PF00664//PF03193//PF00005 Type II/IV secretion system protein//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0006200//GO:0006810//GO:0055085 obsolete ATP catabolic process//transport//transmembrane transport GO:0042626//GO:0016887//GO:0016301//GO:0005525//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.44328 BF_2 1128.74 21.77 2456 189238013 XP_001813375.1 2718 1.1e-304 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] 687022023 LM523171.1 55 2.95716e-17 Parastrongyloides trichosuri genome assembly P_trichosuri_KNP ,scaffold PTRK_scaffold0000014 K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q61102 1926 3.1e-214 ATP-binding cassette sub-family B member 7, mitochondrial OS=Mus musculus GN=Abcb7 PE=1 SV=3 PF00437//PF06414//PF13304//PF00664//PF03193//PF00005 Type II/IV secretion system protein//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0055085//GO:0006200//GO:0006810 transmembrane transport//obsolete ATP catabolic process//transport GO:0016887//GO:0016301//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.44332 BF_2 30.00 1.68 1035 391337758 XP_003743232.1 255 1.8e-19 PREDICTED: uncharacterized protein LOC100899973 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44334 BF_2 673.32 3.14 9249 189235087 XP_001808767.1 4590 0.0e+00 PREDICTED: leucine-rich repeat-containing protein 16A [Tribolium castaneum] 808129414 XM_003397808.2 142 4.87447e-65 PREDICTED: Bombus terrestris DNA/RNA-binding protein KIN17 (LOC100644094), mRNA -- -- -- -- Q5VZK9 1592 6.2e-175 Leucine-rich repeat-containing protein 16A OS=Homo sapiens GN=LRRC16A PE=1 SV=1 PF00560//PF07062 Leucine Rich Repeat//Clc-like -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2837 Protein containing a U1-type Zn-finger and implicated in RNA splicing or processing Cluster-8309.44336 BF_2 39.01 1.16 1690 478259929 ENN79731.1 747 2.6e-76 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 407 2.9e-38 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.44337 BF_2 541.25 3.77 6297 642929205 XP_008195735.1 6293 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 848 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 2954 0.0e+00 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF01506//PF00400 Hepatitis C virus non-structural 5a protein membrane anchor//WD domain, G-beta repeat GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0004197//GO:0004252//GO:0017111//GO:0005515 RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//serine-type endopeptidase activity//nucleoside-triphosphatase activity//protein binding GO:0031379 RNA-directed RNA polymerase complex KOG4155 FOG: WD40 repeat Cluster-8309.44338 BF_2 1242.00 15.29 3686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44339 BF_2 697.02 4.75 6428 642918222 XP_008191418.1 7410 0.0e+00 PREDICTED: transcription initiation factor TFIID subunit 1 isoform X1 [Tribolium castaneum]>gi|270003291|gb|EEZ99738.1| hypothetical protein TcasGA2_TC002507 [Tribolium castaneum] 795022714 XM_012005302.1 590 0 PREDICTED: Vollenhovia emeryi transcription initiation factor TFIID subunit 1 (LOC105557903), mRNA K03125 TAF1 transcription initiation factor TFIID subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03125 Q8IZX4 3968 0.0e+00 Transcription initiation factor TFIID subunit 1-like OS=Homo sapiens GN=TAF1L PE=1 SV=1 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG0008 Transcription initiation factor TFIID, subunit TAF1 Cluster-8309.44340 BF_2 23.83 0.39 2841 642928778 XP_008195558.1 1770 1.1e-194 PREDICTED: hexosaminidase 1 isoform X2 [Tribolium castaneum] 755880535 XM_005185434.2 54 1.23189e-16 PREDICTED: Musca domestica chitooligosaccharidolytic beta-N-acetylglucosaminidase (LOC101894273), mRNA K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49010 1441 6.1e-158 Chitooligosaccharidolytic beta-N-acetylglucosaminidase OS=Bombyx mori PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.44341 BF_2 453.46 5.15 3974 546676181 ERL87248.1 2281 8.2e-254 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9J0 409 4.0e-38 Mycosubtilin synthase subunit B OS=Bacillus subtilis GN=mycB PE=3 SV=1 PF02733//PF00501 Dak1 domain//AMP-binding enzyme GO:0008152//GO:0046486//GO:0006071 metabolic process//glycerolipid metabolic process//glycerol metabolic process GO:0003824//GO:0004371 catalytic activity//glycerone kinase activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.44342 BF_2 90.00 0.85 4697 642925942 XP_008194705.1 4442 0.0e+00 PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3-like [Tribolium castaneum] 642925941 XM_008196483.1 58 1.2233e-18 PREDICTED: Tribolium castaneum voltage-dependent calcium channel subunit alpha-2/delta-3-like (LOC662338), mRNA K05316 CACNA2DN voltage-dependent calcium channel alpha-2/delta, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05316 Q7Z3S7 1097 7.8e-118 Voltage-dependent calcium channel subunit alpha-2/delta-4 OS=Homo sapiens GN=CACNA2D4 PE=1 SV=2 PF00469//PF06112 Negative factor, (F-Protein) or Nef//Gammaherpesvirus capsid protein -- -- GO:0005525 GTP binding GO:0019028 viral capsid KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.44343 BF_2 303.47 3.02 4496 642926401 XP_008191947.1 3150 0.0e+00 PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|642926403|ref|XP_008191948.1| PREDICTED: nuclear hormone receptor FTZ-F1 beta [Tribolium castaneum]>gi|270009223|gb|EFA05671.1| hormone receptor in 39-like protein [Tribolium castaneum] 642926402 XM_008193726.1 635 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 beta (LOC658947), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 Q05192 1612 1.4e-177 Nuclear hormone receptor FTZ-F1 beta OS=Drosophila melanogaster GN=Hr39 PE=1 SV=3 PF00104//PF00105//PF03846 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains)//Cell division inhibitor SulA GO:0006355//GO:0051782//GO:0043401//GO:0009432//GO:0007165 regulation of transcription, DNA-templated//negative regulation of cell division//steroid hormone mediated signaling pathway//SOS response//signal transduction GO:0008270//GO:0043565//GO:0003700//GO:0046872//GO:0003707 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//steroid hormone receptor activity GO:0009276//GO:0005634//GO:0005667 Gram-negative-bacterium-type cell wall//nucleus//transcription factor complex -- -- Cluster-8309.44345 BF_2 8.00 197.56 212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44351 BF_2 480.47 4.12 5168 189240067 XP_970199.2 2407 2.6e-268 PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|642931791|ref|XP_008196730.1| PREDICTED: monocarboxylate transporter 13 [Tribolium castaneum]>gi|270011736|gb|EFA08184.1| hypothetical protein TcasGA2_TC005811 [Tribolium castaneum] 815907549 XM_012384084.1 85 1.31863e-33 PREDICTED: Bombus impatiens uncharacterized LOC100748998 (LOC100748998), transcript variant X4, mRNA K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6GM59 478 5.2e-46 Monocarboxylate transporter 12 OS=Xenopus laevis GN=slc16a12 PE=2 SV=1 PF00083//PF08040//PF07690//PF05480 Sugar (and other) transporter//MNLL subunit//Major Facilitator Superfamily//Staphylococcus haemolytic protein GO:0006118//GO:0009405//GO:0055085 obsolete electron transport//pathogenesis//transmembrane transport GO:0003954//GO:0022857 NADH dehydrogenase activity//transmembrane transporter activity GO:0005739//GO:0016021 mitochondrion//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.44353 BF_2 102.14 0.53 8329 642934565 XP_008197717.1 3682 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF01533//PF00069//PF06293//PF07714 Tospovirus nucleocapsid protein//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524//GO:0000166 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding//nucleotide binding GO:0019013//GO:0016020 viral nucleocapsid//membrane KOG0611 Predicted serine/threonine protein kinase Cluster-8309.44354 BF_2 66.00 2.93 1229 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44356 BF_2 145.58 1.18 5458 407731620 AFU25696.1 4540 0.0e+00 Na+,K+ ATPase alpha-subunit 2, partial [Tetraopes tetrophthalmus] 407731619 JQ771527.1 1269 0 Tetraopes tetrophthalmus Na+,K+ ATPase alpha-subunit 2 mRNA, partial cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 2978 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF04565 E1-E2 ATPase//RNA polymerase Rpb2, domain 3 GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0000166//GO:0003677//GO:0003899 metal ion binding//nucleotide binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.44358 BF_2 147.36 6.39 1252 242022723 XP_002431788.1 717 5.9e-73 papilin, putative [Pediculus humanus corporis]>gi|212517113|gb|EEB19050.1| papilin, putative [Pediculus humanus corporis] -- -- -- -- -- -- -- -- -- Q868Z9 612 3.6e-62 Papilin OS=Drosophila melanogaster GN=Ppn PE=1 SV=2 PF00014//PF02226 Kunitz/Bovine pancreatic trypsin inhibitor domain//Picornavirus coat protein (VP4) -- -- GO:0004867//GO:0005198 serine-type endopeptidase inhibitor activity//structural molecule activity GO:0019028 viral capsid KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.44359 BF_2 826.95 7.69 4784 642915090 XP_008190408.1 1130 2.9e-120 PREDICTED: probable uridine-cytidine kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 910 3.9e-96 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF00485//PF06414//PF01121//PF09547//PF00437//PF07690//PF02224//PF00083//PF03810 Phosphoribulokinase / Uridine kinase family//Zeta toxin//Dephospho-CoA kinase//Stage IV sporulation protein A (spore_IV_A)//Type II/IV secretion system protein//Major Facilitator Superfamily//Cytidylate kinase//Sugar (and other) transporter//Importin-beta N-terminal domain GO:0015937//GO:0006886//GO:0006810//GO:0006139//GO:0015940//GO:0055085//GO:0043934//GO:0006206//GO:0008152 coenzyme A biosynthetic process//intracellular protein transport//transport//nucleobase-containing compound metabolic process//pantothenate biosynthetic process//transmembrane transport//sporulation//pyrimidine nucleobase metabolic process//metabolic process GO:0004127//GO:0016887//GO:0016301//GO:0005524//GO:0004140//GO:0008536//GO:0022857 cytidylate kinase activity//ATPase activity//kinase activity//ATP binding//dephospho-CoA kinase activity//Ran GTPase binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.44360 BF_2 117.78 3.80 1585 91082413 XP_976289.1 522 3.0e-50 PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922599|ref|XP_008193242.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922601|ref|XP_008193243.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922603|ref|XP_008193244.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922605|ref|XP_008193245.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922607|ref|XP_008193246.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|270007164|gb|EFA03612.1| hypothetical protein TcasGA2_TC013700 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44361 BF_2 24.86 0.37 3061 642915291 XP_008190557.1 1402 5.3e-152 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 656 7.0e-67 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.44362 BF_2 59.91 1.64 1820 642915291 XP_008190557.1 1278 7.6e-138 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8K2V1 596 3.8e-60 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Mus musculus GN=Ppp4r1 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0211 Protein phosphatase 2A regulatory subunit A and related proteins Cluster-8309.44363 BF_2 3090.72 15.24 8771 642912633 XP_008200941.1 4927 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q96RL7 2069 2.9e-230 Vacuolar protein sorting-associated protein 13A OS=Homo sapiens GN=VPS13A PE=1 SV=2 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.44365 BF_2 222.00 8.51 1379 641658103 XP_008180598.1 716 8.5e-73 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8TAQ5 685 1.4e-70 Zinc finger protein 420 OS=Homo sapiens GN=ZNF420 PE=1 SV=1 PF00412//PF13912//PF15178//PF00346//PF02178//PF13465//PF07975//PF00096 LIM domain//C2H2-type zinc finger//Mitochondrial import receptor subunit TOM5 homolog//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//AT hook motif//Zinc-finger double domain//TFIIH C1-like domain//Zinc finger, C2H2 type GO:0006281//GO:0055114 DNA repair//oxidation-reduction process GO:0003677//GO:0051287//GO:0016651//GO:0008270//GO:0048038//GO:0046872 DNA binding//NAD binding//oxidoreductase activity, acting on NAD(P)H//zinc ion binding//quinone binding//metal ion binding GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.44366 BF_2 86.86 1.07 3679 91089675 XP_974428.1 1381 1.7e-149 PREDICTED: probable trans-2-enoyl-CoA reductase, mitochondrial [Tribolium castaneum]>gi|270012629|gb|EFA09077.1| hypothetical protein TcasGA2_TC006794 [Tribolium castaneum] -- -- -- -- -- K07512 MECR, NRBF1 mitochondrial trans-2-enoyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K07512 Q9V6U9 1031 2.8e-110 Probable trans-2-enoyl-CoA reductase, mitochondrial OS=Drosophila melanogaster GN=CG16935 PE=3 SV=2 PF08240//PF00107 Alcohol dehydrogenase GroES-like domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0008270//GO:0000166//GO:0016491 zinc ion binding//nucleotide binding//oxidoreductase activity -- -- KOG0025 Zn2+-binding dehydrogenase (nuclear receptor binding factor-1) Cluster-8309.44367 BF_2 58.00 3.58 964 332373302 AEE61792.1 375 2.1e-33 unknown [Dendroctonus ponderosae]>gi|546684141|gb|ERL93846.1| hypothetical protein D910_11132 [Dendroctonus ponderosae] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 263 8.2e-22 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF04101//PF02432//PF00201 Glycosyltransferase family 28 C-terminal domain//Fimbrial, major and minor subunit//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152//GO:0007155 metabolic process//cell adhesion GO:0016758 transferase activity, transferring hexosyl groups GO:0009289 pilus -- -- Cluster-8309.44369 BF_2 1.00 3.42 265 332373302 AEE61792.1 251 1.3e-19 unknown [Dendroctonus ponderosae]>gi|546684141|gb|ERL93846.1| hypothetical protein D910_11132 [Dendroctonus ponderosae] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 158 3.4e-10 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44370 BF_2 240.00 19.97 790 91090210 XP_967762.1 666 3.0e-67 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09426 224 2.2e-17 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Rattus norvegicus GN=Ugt8 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016740//GO:0016758 transferase activity//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44371 BF_2 89.00 26.32 428 270013462 EFA09910.1 516 4.1e-50 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08541 310 1.3e-27 UDP-glucuronosyltransferase 2B2 OS=Rattus norvegicus GN=Ugt2b PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44372 BF_2 517.67 12.74 1987 91090214 XP_967924.1 1409 5.3e-153 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08541 585 7.8e-59 UDP-glucuronosyltransferase 2B2 OS=Rattus norvegicus GN=Ugt2b PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44373 BF_2 24.75 0.65 1892 91090214 XP_967924.1 1334 2.5e-144 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08541 623 2.9e-63 UDP-glucuronosyltransferase 2B2 OS=Rattus norvegicus GN=Ugt2b PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44374 BF_2 125.52 4.36 1492 91090214 XP_967924.1 1157 6.7e-124 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08542 556 1.3e-55 UDP-glucuronosyltransferase 2B17 OS=Rattus norvegicus GN=Ugt2b17 PE=2 SV=2 PF04101//PF00201//PF00502 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Phycobilisome protein GO:0015979//GO:0008152 photosynthesis//metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0030089 phycobilisome -- -- Cluster-8309.44375 BF_2 67.06 2.54 1392 270013462 EFA09910.1 1126 2.4e-120 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q09426 424 2.5e-40 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Rattus norvegicus GN=Ugt8 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.44378 BF_2 49.69 0.32 6707 270000722 EEZ97169.1 1408 2.4e-152 hypothetical protein TcasGA2_TC004356 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 802 1.8e-83 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00018//PF14604//PF00621//PF00130//PF00307 SH3 domain//Variant SH3 domain//RhoGEF domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Calponin homology (CH) domain GO:0035556//GO:0035023//GO:0043087 intracellular signal transduction//regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.44379 BF_2 2536.93 5.49 19620 642937892 XP_008200345.1 18892 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR4 isoform X1 [Tribolium castaneum] 755931779 XM_011315804.1 195 3.57072e-94 PREDICTED: Fopius arisanus protein purity of essence (LOC105273389), transcript variant X4, mRNA K10691 UBR4, ZUBR1 E3 ubiquitin-protein ligase UBR4 http://www.genome.jp/dbget-bin/www_bget?ko:K10691 Q5T4S7 10400 0.0e+00 E3 ubiquitin-protein ligase UBR4 OS=Homo sapiens GN=UBR4 PE=1 SV=1 PF03488//PF01667//PF02806//PF04410//PF03875//PF02207 Nematode insulin-related peptide beta type//Ribosomal protein S27//Alpha amylase, C-terminal all-beta domain//Gar1/Naf1 RNA binding region//Statherin//Putative zinc finger in N-recognin (UBR box) GO:0006412//GO:0001522//GO:0042254//GO:0005975//GO:0007165//GO:0030500//GO:0042742 translation//pseudouridine synthesis//ribosome biogenesis//carbohydrate metabolic process//signal transduction//regulation of bone mineralization//defense response to bacterium GO:0043169//GO:0005179//GO:0003824//GO:0003735//GO:0008270//GO:0046848 cation binding//hormone activity//catalytic activity//structural constituent of ribosome//zinc ion binding//hydroxyapatite binding GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1776 Zn-binding protein Push Cluster-8309.44382 BF_2 932.11 14.84 2915 332373440 AEE61861.1 1521 8.1e-166 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RDN7 1071 5.0e-115 Carboxypeptidase Q OS=Pongo abelii GN=CPQ PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2195 Transferrin receptor and related proteins containing the protease-associated (PA) domain Cluster-8309.44384 BF_2 82.56 0.77 4778 546678584 ERL89166.1 1205 5.8e-129 hypothetical protein D910_06541, partial [Dendroctonus ponderosae] -- -- -- -- -- K08002 MMP24 matrix metalloproteinase-24 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K08002 Q9GLE4 481 2.1e-46 Matrix metalloproteinase-14 OS=Bos taurus GN=MMP14 PE=2 SV=1 PF01400//PF07998//PF00413//PF10462//PF02691 Astacin (Peptidase family M12A)//Peptidase family M54//Matrixin//Peptidase M66//Vacuolating cyotoxin GO:0006508//GO:0009405 proteolysis//pathogenesis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0005576//GO:0031012 extracellular region//extracellular matrix -- -- Cluster-8309.44385 BF_2 12.73 0.48 1389 478254210 ENN74475.1 1424 6.8e-155 hypothetical protein YQE_08921, partial [Dendroctonus ponderosae] -- -- -- -- -- K02085 APC adenomatosis polyposis coli protein http://www.genome.jp/dbget-bin/www_bget?ko:K02085 P70478 882 2.0e-93 Adenomatous polyposis coli protein OS=Rattus norvegicus GN=Apc PE=1 SV=1 PF10280//PF00514//PF05972 Mediator complex protein//Armadillo/beta-catenin-like repeat//APC 15 residue motif GO:0006357//GO:0016055 regulation of transcription from RNA polymerase II promoter//Wnt signaling pathway GO:0008013//GO:0001104//GO:0005515 beta-catenin binding//RNA polymerase II transcription cofactor activity//protein binding GO:0016592//GO:0016342 mediator complex//catenin complex KOG2122 Beta-catenin-binding protein APC, contains ARM repeats Cluster-8309.44386 BF_2 28.71 1.48 1100 189234473 XP_001808764.1 1072 3.5e-114 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] 662206050 XM_008478247.1 93 9.7879e-39 PREDICTED: Diaphorina citri double-strand-break repair protein rad21 homolog (LOC103513421), mRNA K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 697 4.4e-72 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF04825//PF06766 N terminus of Rad21 / Rec8 like protein//Fungal hydrophobin -- -- GO:0005515 protein binding GO:0000228//GO:0005576 nuclear chromosome//extracellular region KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.44387 BF_2 347.18 11.11 1594 332373278 AEE61780.1 1520 5.8e-166 unknown [Dendroctonus ponderosae]>gi|546685176|gb|ERL94703.1| hypothetical protein D910_11977 [Dendroctonus ponderosae] -- -- -- -- -- K12164 UBA5, UBE1DC1 ubiquitin-like modifier-activating enzyme 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12164 B9VJ80 1329 3.3e-145 Ubiquitin-like modifier-activating enzyme 5 OS=Bombyx mori PE=2 SV=1 PF01494//PF03435//PF02558//PF02826//PF03721//PF00899//PF00831 FAD binding domain//Saccharopine dehydrogenase NADP binding domain//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Ribosomal L29 protein GO:0055114//GO:0042254//GO:0015940//GO:0006412 oxidation-reduction process//ribosome biogenesis//pantothenate biosynthetic process//translation GO:0008677//GO:0003735//GO:0008641//GO:0071949//GO:0016491//GO:0051287//GO:0016616 2-dehydropantoate 2-reductase activity//structural constituent of ribosome//small protein activating enzyme activity//FAD binding//oxidoreductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0005622//GO:0005840 intracellular//ribosome KOG2336 Molybdopterin biosynthesis-related protein Cluster-8309.44389 BF_2 524.46 2.76 8243 270009943 EFA06391.1 325 1.1e-26 hypothetical protein TcasGA2_TC009269 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12009//PF00570//PF12356//PF12763 Telomerase ribonucleoprotein complex - RNA binding domain//HRDC domain//Protein of unknown function (DUF3643)//Cytoskeletal-regulatory complex EF hand GO:0032465//GO:0006278//GO:0016567//GO:0006915 regulation of cytokinesis//RNA-dependent DNA replication//protein ubiquitination//apoptotic process GO:0003964//GO:0005515//GO:0004842//GO:0003676 RNA-directed DNA polymerase activity//protein binding//ubiquitin-protein transferase activity//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.44391 BF_2 19.77 0.34 2692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44393 BF_2 1753.88 40.14 2115 91087035 XP_974421.1 1714 2.4e-188 PREDICTED: E3 ubiquitin-protein ligase synoviolin A [Tribolium castaneum]>gi|642929379|ref|XP_008195811.1| PREDICTED: E3 ubiquitin-protein ligase synoviolin A [Tribolium castaneum]>gi|642929381|ref|XP_008195812.1| PREDICTED: E3 ubiquitin-protein ligase synoviolin A [Tribolium castaneum]>gi|270010520|gb|EFA06968.1| hypothetical protein TcasGA2_TC009927 [Tribolium castaneum] 733931137 XM_010727931.1 111 1.88241e-48 PREDICTED: Meleagris gallopavo E3 ubiquitin-protein ligase synoviolin-like (LOC104916890), mRNA K10601 SYVN1, HRD1 E3 ubiquitin-protein ligase synoviolin http://www.genome.jp/dbget-bin/www_bget?ko:K10601 Q9DBY1 1238 1.6e-134 E3 ubiquitin-protein ligase synoviolin OS=Mus musculus GN=Syvn1 PE=1 SV=3 PF11789//PF14634//PF12906//PF12678//PF17123//PF17122//PF00097//PF13639//PF12861 Zinc-finger of the MIZ type in Nse subunit//zinc-RING finger domain//RING-variant domain//RING-H2 zinc finger//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0008270//GO:0043169//GO:0004842//GO:0046872//GO:0005515 zinc ion binding//cation binding//ubiquitin-protein transferase activity//metal ion binding//protein binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.44394 BF_2 238.19 1.21 8526 478262704 ENN81251.1 2158 3.2e-239 hypothetical protein YQE_02345, partial [Dendroctonus ponderosae]>gi|546679053|gb|ERL89576.1| hypothetical protein D910_06941 [Dendroctonus ponderosae] 759080227 XM_011351649.1 232 4.1851e-115 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X5, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1209 1.5e-130 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.44396 BF_2 617.12 7.34 3806 642925611 XP_008194640.1 2652 7.5e-297 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.7e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44397 BF_2 37.08 0.84 2142 91076406 XP_969383.1 1230 3.3e-132 PREDICTED: aldose reductase [Tribolium castaneum]>gi|642912326|ref|XP_008200648.1| PREDICTED: aldose reductase [Tribolium castaneum]>gi|270002562|gb|EEZ99009.1| hypothetical protein TcasGA2_TC004877 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 768 5.0e-80 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.44400 BF_2 1319.85 7.51 7639 91085823 XP_974821.1 3077 0.0e+00 PREDICTED: bone morphogenetic protein receptor type-2 [Tribolium castaneum]>gi|270011027|gb|EFA07475.1| wishful thinking [Tribolium castaneum] -- -- -- -- -- K04671 BMPR2 bone morphogenetic protein receptor type-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04671 O35607 801 2.7e-83 Bone morphogenetic protein receptor type-2 OS=Mus musculus GN=Bmpr2 PE=1 SV=1 PF00069//PF01064//PF03460//PF03829//PF06221//PF07714 Protein kinase domain//Activin types I and II receptor domain//Nitrite/Sulfite reductase ferredoxin-like half domain//PTS system glucitol/sorbitol-specific IIA component//Putative zinc finger motif, C2HC5-type//Protein tyrosine kinase GO:0008643//GO:0016310//GO:0055114//GO:0009401//GO:0006355//GO:0006468//GO:0023014//GO:0009069//GO:0007178 carbohydrate transport//phosphorylation//oxidation-reduction process//phosphoenolpyruvate-dependent sugar phosphotransferase system//regulation of transcription, DNA-templated//protein phosphorylation//signal transduction by protein phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004672//GO:0008982//GO:0004675//GO:0005024//GO:0016491//GO:0008270//GO:0004702//GO:0005524 protein kinase activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//transmembrane receptor protein serine/threonine kinase activity//transforming growth factor beta-activated receptor activity//oxidoreductase activity//zinc ion binding//receptor signaling protein serine/threonine kinase activity//ATP binding GO:0016020//GO:0005634//GO:0005737//GO:0009357 membrane//nucleus//cytoplasm//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex -- -- Cluster-8309.44401 BF_2 1463.80 12.58 5154 642919776 XP_008192060.1 5683 0.0e+00 PREDICTED: multidrug resistance-associated protein 7 [Tribolium castaneum] -- -- -- -- -- K05674 ABCC10 ATP-binding cassette, subfamily C (CFTR/MRP), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K05674 Q5T3U5 2041 3.0e-227 Multidrug resistance-associated protein 7 OS=Homo sapiens GN=ABCC10 PE=1 SV=1 PF01926//PF13304//PF00664//PF03193//PF00005//PF00004 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA) GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.44402 BF_2 364.98 4.70 3533 91082077 XP_966548.1 1186 6.9e-127 PREDICTED: zinc finger CCCH domain-containing protein 10 [Tribolium castaneum]>gi|270007415|gb|EFA03863.1| hypothetical protein TcasGA2_TC013984 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96K80 323 3.3e-28 Zinc finger CCCH domain-containing protein 10 OS=Homo sapiens GN=ZC3H10 PE=1 SV=1 PF02183//PF16326//PF04977 Homeobox associated leucine zipper//ABC transporter C-terminal domain//Septum formation initiator GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0005488//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.44403 BF_2 11.83 0.50 1273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44404 BF_2 122.94 1.90 2991 282158097 NP_001164092.1 989 4.1e-104 quaking related [Tribolium castaneum] -- -- -- -- -- K17843 KHDRBS2, SLM1 KH domain-containing, RNA-binding, signal transduction-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17843 Q920F3 502 4.9e-49 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Rattus norvegicus GN=Khdrbs2 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.44406 BF_2 2308.03 37.29 2876 237681141 NP_001153713.1 2130 1.9e-236 glycerol kinase-like [Tribolium castaneum]>gi|270003063|gb|EEZ99510.1| hypothetical protein TcasGA2_TC000091 [Tribolium castaneum] -- -- -- -- -- K00864 glpK, GK glycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00864 Q14409 1486 3.8e-163 Putative glycerol kinase 3 OS=Homo sapiens GN=GK3P PE=5 SV=2 PF02782//PF00370 FGGY family of carbohydrate kinases, C-terminal domain//FGGY family of carbohydrate kinases, N-terminal domain GO:0006072//GO:0016310//GO:0046486//GO:0005975 glycerol-3-phosphate metabolic process//phosphorylation//glycerolipid metabolic process//carbohydrate metabolic process GO:0016773//GO:0004370 phosphotransferase activity, alcohol group as acceptor//glycerol kinase activity -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.44408 BF_2 590.57 3.53 7281 642930496 XP_008196428.1 2252 3.5e-250 PREDICTED: CLIP-associating protein isoform X3 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 A1A5G0 890 1.2e-93 CLIP-associating protein 1 OS=Xenopus tropicalis GN=clasp1 PE=1 SV=1 PF01602//PF01528//PF02985 Adaptin N terminal region//Herpesvirus glycoprotein M//HEAT repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0016020//GO:0030117 membrane//membrane coat -- -- Cluster-8309.44411 BF_2 55.86 0.33 7387 642935532 XP_008198047.1 2202 2.2e-244 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Tribolium castaneum]>gi|270013328|gb|EFA09776.1| hypothetical protein TcasGA2_TC011918 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q14642 962 5.6e-102 Type I inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens GN=INPP5A PE=1 SV=1 -- -- GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG1976 Inositol polyphosphate 5-phosphatase, type I Cluster-8309.44414 BF_2 90.78 0.75 5346 189235691 XP_966538.2 1798 1.1e-197 PREDICTED: limbic system-associated membrane protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EHU7 696 2.8e-71 Endoplasmic reticulum-Golgi intermediate compartment protein 2 OS=Gecko japonicus GN=ERGIC2 PE=2 SV=1 PF13895//PF00041//PF15333//PF11629 Immunoglobulin domain//Fibronectin type III domain//TATA box-binding protein-associated factor 1D//C terminal SARAH domain of Mst1 GO:0016310//GO:0009069//GO:0006355 phosphorylation//serine family amino acid metabolic process//regulation of transcription, DNA-templated GO:0005515//GO:0004674 protein binding//protein serine/threonine kinase activity GO:0005668//GO:0005634 RNA polymerase transcription factor SL1 complex//nucleus KOG2667 COPII vesicle protein Cluster-8309.44416 BF_2 622.22 6.29 4425 189235691 XP_966538.2 1798 9.3e-198 PREDICTED: limbic system-associated membrane protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EHU7 696 2.3e-71 Endoplasmic reticulum-Golgi intermediate compartment protein 2 OS=Gecko japonicus GN=ERGIC2 PE=2 SV=1 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- KOG2667 COPII vesicle protein Cluster-8309.44417 BF_2 178.15 1.38 5687 270007804 EFA04252.1 2632 2.3e-294 hypothetical protein TcasGA2_TC014542 [Tribolium castaneum] 831223259 XM_012804206.1 235 5.9899e-117 PREDICTED: Otolemur garnettii RAN binding protein 9 (RANBP9), mRNA -- -- -- -- Q96S59 1739 3.4e-192 Ran-binding protein 9 OS=Homo sapiens GN=RANBP9 PE=1 SV=1 PF06005//PF00622//PF17122//PF07989//PF08513//PF04977 Protein of unknown function (DUF904)//SPRY domain//Zinc-finger//Centrosomin N-terminal motif 1//LisH//Septum formation initiator GO:0000917//GO:0043093//GO:0007049 barrier septum assembly//FtsZ-dependent cytokinesis//cell cycle GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005737//GO:0005815 cytoplasm//microtubule organizing center KOG1477 SPRY domain-containing proteins Cluster-8309.44418 BF_2 405.00 4.81 3808 270010332 EFA06780.1 1053 2.0e-111 hypothetical protein TcasGA2_TC009716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44421 BF_2 267.00 16.80 952 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44423 BF_2 48.70 2.69 1045 642931033 XP_008196186.1 410 1.9e-37 PREDICTED: uncharacterized protein LOC103313792 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05497 Destabilase GO:0005975 carbohydrate metabolic process GO:0003796 lysozyme activity -- -- -- -- Cluster-8309.44424 BF_2 458.56 4.81 4279 478253821 ENN74113.1 4520 0.0e+00 hypothetical protein YQE_09086, partial [Dendroctonus ponderosae]>gi|546684626|gb|ERL94243.1| hypothetical protein D910_11524 [Dendroctonus ponderosae] 817219709 XM_012430138.1 107 6.42355e-46 PREDICTED: Orussus abietinus contactin (LOC105702510), transcript variant X2, mRNA -- -- -- -- Q9VN14 3311 0.0e+00 Contactin OS=Drosophila melanogaster GN=Cont PE=1 SV=2 PF16656//PF13895//PF01618//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//MotA/TolQ/ExbB proton channel family//Fibronectin type III domain GO:0006810//GO:0019497//GO:0006771//GO:0015031 transport//hexachlorocyclohexane metabolic process//riboflavin metabolic process//protein transport GO:0005515//GO:0003993//GO:0008565//GO:0046872 protein binding//acid phosphatase activity//protein transporter activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.44425 BF_2 27.74 2.00 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44426 BF_2 401.71 2.65 6638 270008506 EFA04954.1 343 7.3e-29 hypothetical protein TcasGA2_TC015023 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.44427 BF_2 651.65 7.35 3994 646714577 KDR18490.1 1909 1.1e-210 Cytospin-A [Zootermopsis nevadensis] 817187826 XM_012433045.1 176 2.63445e-84 PREDICTED: Orussus abietinus cytospin-A (LOC105704102), transcript variant X5, mRNA -- -- -- -- Q2KN98 542 1.5e-53 Cytospin-A OS=Mus musculus GN=Specc1l PE=1 SV=1 PF07926//PF03920//PF00307//PF06667 TPR/MLP1/MLP2-like protein//Groucho/TLE N-terminal Q-rich domain//Calponin homology (CH) domain//Phage shock protein B GO:0006355//GO:0006606//GO:0009271 regulation of transcription, DNA-templated//protein import into nucleus//phage shock GO:0005515 protein binding -- -- KOG4678 FOG: Calponin homology domain Cluster-8309.44429 BF_2 2310.47 10.86 9191 270002460 EEZ98907.1 4938 0.0e+00 hypothetical protein TcasGA2_TC004526 [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q5ZIX8 1803 2.1e-199 Lysine-specific demethylase 3A OS=Gallus gallus GN=KDM3A PE=2 SV=1 PF07649//PF01363//PF02148 C1-like domain//FYVE zinc finger//Zn-finger in ubiquitin-hydrolases and other protein GO:0055114 oxidation-reduction process GO:0047134//GO:0046872//GO:0008270 protein-disulfide reductase activity//metal ion binding//zinc ion binding -- -- KOG1356 Putative transcription factor 5qNCA, contains JmjC domain Cluster-8309.44430 BF_2 316.51 2.69 5211 642912265 XP_008200629.1 1906 3.3e-210 PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912267|ref|XP_008200630.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum]>gi|642912269|ref|XP_008200631.1| PREDICTED: probable JmjC domain-containing histone demethylation protein 2C [Tribolium castaneum] -- -- -- -- -- K15601 KDM3 lysine-specific demethylase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15601 Q6IRB8 281 3.6e-23 Lysine-specific demethylase 3A-A OS=Xenopus laevis GN=kdm3a-a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44431 BF_2 1065.52 3.77 12107 91092426 XP_968165.1 6155 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC1 [Tribolium castaneum]>gi|270004743|gb|EFA01191.1| hypothetical protein TcasGA2_TC010518 [Tribolium castaneum] 617460781 XM_007571860.1 414 0 PREDICTED: Poecilia formosa ATP-binding cassette, sub-family E (OABP), member 1 (abce1), mRNA K03018 RPC1, POLR3A DNA-directed RNA polymerase III subunit RPC1 http://www.genome.jp/dbget-bin/www_bget?ko:K03018 Q5ZL98 4386 0.0e+00 DNA-directed RNA polymerase III subunit RPC1 OS=Gallus gallus GN=POLR3A PE=2 SV=1 PF04997//PF02367//PF00623//PF04998//PF00931//PF13304//PF07728//PF08477//PF05000//PF04983//PF00004//PF03193//PF00005//PF00910//PF07851//PF07352//PF00448//PF01920//PF06810 RNA polymerase Rpb1, domain 1//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 5//NB-ARC domain//AAA domain, putative AbiEii toxin, Type IV TA system//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 3//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//RNA helicase//TMPIT-like protein//Bacteriophage Mu Gam like protein//SRP54-type protein, GTPase domain//Prefoldin subunit//Phage minor structural protein GP20 GO:0007264//GO:0002949//GO:0006206//GO:0006144//GO:0042262//GO:0006351//GO:0006457//GO:0006614 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//DNA protection//transcription, DNA-templated//protein folding//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0003690//GO:0005525//GO:0032549//GO:0043531//GO:0003723//GO:0003677//GO:0008270//GO:0051082//GO:0016887//GO:0005198//GO:0003924//GO:0005524//GO:0003899 RNA helicase activity//double-stranded DNA binding//GTP binding//ribonucleoside binding//ADP binding//RNA binding//DNA binding//zinc ion binding//unfolded protein binding//ATPase activity//structural molecule activity//GTPase activity//ATP binding//DNA-directed RNA polymerase activity GO:0005634//GO:0016272//GO:0005730//GO:0016021 nucleus//prefoldin complex//nucleolus//integral component of membrane KOG0261 RNA polymerase III, large subunit Cluster-8309.44433 BF_2 71.49 1.01 3241 -- -- -- -- -- 462302786 APGK01050086.1 56 1.08811e-17 Dendroctonus ponderosae Seq01050096, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44434 BF_2 88.38 1.23 3288 646706689 KDR13796.1 370 2.7e-32 PDZ domain-containing protein 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O54824 231 1.4e-17 Pro-interleukin-16 OS=Mus musculus GN=Il16 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44435 BF_2 362.97 4.79 3460 642915809 XP_008200087.1 573 8.1e-56 PREDICTED: 4-coumarate--CoA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27757 196 1.7e-13 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.44440 BF_2 67.16 1.68 1957 642927980 XP_008195470.1 1064 5.3e-113 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08685 GON domain -- -- GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.44442 BF_2 48.72 0.91 2524 91084751 XP_971582.1 1374 7.8e-149 PREDICTED: scavenger receptor class B member 1-like [Tribolium castaneum]>gi|642925852|ref|XP_008190558.1| PREDICTED: scavenger receptor class B member 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 447 9.9e-43 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.44445 BF_2 70.00 0.34 8830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03554//PF03502 UL73 viral envelope glycoprotein//Nucleoside-specific channel-forming protein, Tsx -- -- -- -- GO:0009279//GO:0019031 cell outer membrane//viral envelope -- -- Cluster-8309.44447 BF_2 61.05 1.11 2593 91082797 XP_967743.1 383 6.5e-34 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q9D3B1 261 3.8e-21 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 2 OS=Mus musculus GN=Hacd2 PE=2 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.44448 BF_2 700.53 25.87 1420 91084625 XP_974579.1 1260 7.2e-136 PREDICTED: cullin-2 [Tribolium castaneum]>gi|270008911|gb|EFA05359.1| hypothetical protein TcasGA2_TC015524 [Tribolium castaneum] -- -- -- -- -- K03870 CUL2 cullin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03870 Q13617 696 7.5e-72 Cullin-2 OS=Homo sapiens GN=CUL2 PE=1 SV=2 PF00888 Cullin family GO:0006511 ubiquitin-dependent protein catabolic process GO:0031625 ubiquitin protein ligase binding GO:0031461 cullin-RING ubiquitin ligase complex KOG2284 E3 ubiquitin ligase, Cullin 2 component Cluster-8309.44450 BF_2 5.00 0.98 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44451 BF_2 6.00 7.02 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44452 BF_2 58.29 1.15 2413 546675819 ERL86931.1 1416 1.0e-153 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 1021 2.6e-109 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 PF01968//PF06723 Hydantoinase/oxoprolinase//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0016787 hydrolase activity -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.44453 BF_2 18.62 0.39 2305 546675819 ERL86931.1 1426 6.6e-155 hypothetical protein D910_04334, partial [Dendroctonus ponderosae] -- -- -- -- -- K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11147 1044 5.4e-112 Heat shock 70 kDa protein cognate 4 OS=Drosophila melanogaster GN=Hsc70-4 PE=1 SV=3 PF01968//PF08273//PF06723 Hydantoinase/oxoprolinase//Zinc-binding domain of primase-helicase//MreB/Mbl protein GO:0006351//GO:0000902//GO:0006269 transcription, DNA-templated//cell morphogenesis//DNA replication, synthesis of RNA primer GO:0004386//GO:0003896//GO:0016787//GO:0008270 helicase activity//DNA primase activity//hydrolase activity//zinc ion binding GO:0005657//GO:0005730 replication fork//nucleolus KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.44455 BF_2 155.66 0.74 9104 642933690 XP_008197522.1 457 6.0e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 229 6.8e-17 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04048//PF02179 Sec8 exocyst complex component specific domain//BAG domain GO:0006904//GO:0015031 vesicle docking involved in exocytosis//protein transport GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.44456 BF_2 200.01 0.97 8900 642933690 XP_008197522.1 457 5.9e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 227 1.1e-16 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF04048//PF02179 Sec8 exocyst complex component specific domain//BAG domain GO:0006904//GO:0015031 vesicle docking involved in exocytosis//protein transport GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.44457 BF_2 128.00 2.71 2260 91080047 XP_972871.1 300 2.4e-24 PREDICTED: protein SREK1IP1 [Tribolium castaneum]>gi|270003217|gb|EEZ99664.1| hypothetical protein TcasGA2_TC002421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N9Q2 188 9.6e-13 Protein SREK1IP1 OS=Homo sapiens GN=SREK1IP1 PE=1 SV=1 PF06459//PF02724//PF05793//PF01080//PF02932 Ryanodine Receptor TM 4-6//CDC45-like protein//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Presenilin//Neurotransmitter-gated ion-channel transmembrane region GO:0006367//GO:0006811//GO:0006874//GO:0006270//GO:0006816//GO:0032968 transcription initiation from RNA polymerase II promoter//ion transport//cellular calcium ion homeostasis//DNA replication initiation//calcium ion transport//positive regulation of transcription elongation from RNA polymerase II promoter GO:0008270//GO:0003676//GO:0005219//GO:0004190//GO:0003677 zinc ion binding//nucleic acid binding//ryanodine-sensitive calcium-release channel activity//aspartic-type endopeptidase activity//DNA binding GO:0016020//GO:0005622//GO:0016021//GO:0005634 membrane//intracellular//integral component of membrane//nucleus KOG2985 Uncharacterized conserved protein Cluster-8309.44459 BF_2 135.09 1.28 4698 91076704 XP_972106.1 1365 1.6e-147 PREDICTED: UDP-galactose translocator [Tribolium castaneum]>gi|270001866|gb|EEZ98313.1| hypothetical protein TcasGA2_TC000767 [Tribolium castaneum] -- -- -- -- -- K15272 SLC35A1_2_3 solute carrier family 35 (UDP-sugar transporter), member A1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15272 Q9R0M8 771 5.0e-80 UDP-galactose translocator OS=Mus musculus GN=Slc35a2 PE=2 SV=1 PF08449//PF04142//PF13371//PF10147//PF13639//PF16685//PF12678//PF14634//PF01297//PF00097//PF00892//PF00175 UAA transporter family//Nucleotide-sugar transporter//Tetratricopeptide repeat//Growth arrest and DNA-damage-inducible proteins-interacting protein 1//Ring finger domain//zinc RING finger of MSL2//RING-H2 zinc finger//zinc-RING finger domain//Zinc-uptake complex component A periplasmic//Zinc finger, C3HC4 type (RING finger)//EamA-like transporter family//Oxidoreductase NAD-binding domain GO:0055085//GO:0055114//GO:0007049//GO:0015780//GO:0030001//GO:0008643 transmembrane transport//oxidation-reduction process//cell cycle//nucleotide-sugar transport//metal ion transport//carbohydrate transport GO:0005351//GO:0008270//GO:0005338//GO:0061630//GO:0016491//GO:0005515//GO:0046872 sugar:proton symporter activity//zinc ion binding//nucleotide-sugar transmembrane transporter activity//ubiquitin protein ligase activity//oxidoreductase activity//protein binding//metal ion binding GO:0016021//GO:0005634//GO:0000139//GO:0016020 integral component of membrane//nucleus//Golgi membrane//membrane KOG2234 Predicted UDP-galactose transporter Cluster-8309.44461 BF_2 812.29 11.99 3121 646696804 KDR08844.1 4269 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component [Zootermopsis nevadensis] 642930974 XM_008197940.1 1005 0 PREDICTED: Tribolium castaneum 116 kDa U5 small nuclear ribonucleoprotein component (LOC661338), mRNA K12852 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component http://www.genome.jp/dbget-bin/www_bget?ko:K12852 Q5F3X4 3877 0.0e+00 116 kDa U5 small nuclear ribonucleoprotein component OS=Gallus gallus GN=EFTUD2 PE=2 SV=1 PF01926//PF08477//PF03144//PF00071//PF03764 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Elongation factor Tu domain 2//Ras family//Elongation factor G, domain IV GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0468 U5 snRNP-specific protein Cluster-8309.44463 BF_2 37.00 2.09 1029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44464 BF_2 41.20 0.49 3803 546685733 ERL95188.1 972 4.8e-102 hypothetical protein D910_12456 [Dendroctonus ponderosae] -- -- -- -- -- K04725 XIAP, BIRC4 E3 ubiquitin-protein ligase XIAP http://www.genome.jp/dbget-bin/www_bget?ko:K04725 P41436 608 3.2e-61 Apoptosis inhibitor IAP OS=Cydia pomonella granulosis virus (isolate Mexico/1963) GN=IAP PE=3 SV=1 PF14634//PF13639 zinc-RING finger domain//Ring finger domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.44467 BF_2 1390.88 31.20 2152 91087131 XP_975238.1 1915 1.2e-211 PREDICTED: trifunctional enzyme subunit beta, mitochondrial [Tribolium castaneum]>gi|270009593|gb|EFA06041.1| hypothetical protein TcasGA2_TC008872 [Tribolium castaneum] -- -- -- -- -- K07509 HADHB acetyl-CoA acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07509 O46629 1508 7.9e-166 Trifunctional enzyme subunit beta, mitochondrial OS=Bos taurus GN=HADHB PE=2 SV=1 PF02803//PF00108//PF08545 Thiolase, C-terminal domain//Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0042967//GO:0006633//GO:0008152 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.44470 BF_2 223.41 12.38 1042 817057502 XP_012269659.1 799 1.5e-82 PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X3 [Athalia rosae]>gi|817057504|ref|XP_012269660.1| PREDICTED: C-1-tetrahydrofolate synthase, cytoplasmic isoform X3 [Athalia rosae] -- -- -- -- -- K00288 MTHFD methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase / formyltetrahydrofolate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00288 O96553 728 1.1e-75 C-1-tetrahydrofolate synthase, cytoplasmic OS=Drosophila melanogaster GN=pug PE=1 SV=4 PF02882//PF00763 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG4230 C1-tetrahydrofolate synthase Cluster-8309.44471 BF_2 158.58 4.09 1911 642935660 XP_008198104.1 481 2.1e-45 PREDICTED: cytochrome b reductase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08370 CYBRD1 cytochrome b reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08370 Q53TN4 208 3.9e-15 Cytochrome b reductase 1 OS=Homo sapiens GN=CYBRD1 PE=1 SV=1 PF01292//PF00033//PF03188 Prokaryotic cytochrome b561//Cytochrome b/b6/petB//Eukaryotic cytochrome b561 GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0009055 electron carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1619 Cytochrome b Cluster-8309.44472 BF_2 1184.00 23.75 2373 313225548 CBY07022.1 161 3.3e-08 unnamed protein product [Oikopleura dioica] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44473 BF_2 918.62 11.93 3509 270013939 EFA10387.1 896 2.9e-93 hypothetical protein TcasGA2_TC012618 [Tribolium castaneum] -- -- -- -- -- K16295 CYBASC3 cytochrome b ascorbate-dependent protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16295 Q95245 298 2.6e-25 Cytochrome b561 OS=Sus scrofa GN=CYB561 PE=2 SV=1 PF03188//PF01292 Eukaryotic cytochrome b561//Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane KOG1619 Cytochrome b Cluster-8309.44476 BF_2 66.90 0.64 4649 91078312 XP_972704.1 2045 2.2e-226 PREDICTED: intraflagellar transport protein 122 homolog [Tribolium castaneum]>gi|270003955|gb|EFA00403.1| hypothetical protein TcasGA2_TC003254 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NYH1 1408 6.7e-154 Intraflagellar transport protein 122 homolog OS=Danio rerio GN=ift122 PE=2 SV=1 PF01363//PF00400//PF13176//PF04053//PF13639//PF00637//PF13181//PF01525 FYVE zinc finger//WD domain, G-beta repeat//Tetratricopeptide repeat//Coatomer WD associated region//Ring finger domain//Region in Clathrin and VPS//Tetratricopeptide repeat//Rotavirus NS26 GO:0016192//GO:0006886//GO:0019079 vesicle-mediated transport//intracellular protein transport//viral genome replication GO:0005198//GO:0005515//GO:0000287//GO:0046872//GO:0008270//GO:0016887 structural molecule activity//protein binding//magnesium ion binding//metal ion binding//zinc ion binding//ATPase activity GO:0030117//GO:0030430 membrane coat//host cell cytoplasm KOG1538 Uncharacterized conserved protein WDR10, contains WD40 repeats Cluster-8309.44479 BF_2 968.96 11.53 3803 642932911 XP_008197183.1 2530 1.1e-282 PREDICTED: ankyrin repeat domain-containing protein 13D isoform X1 [Tribolium castaneum]>gi|270012473|gb|EFA08921.1| hypothetical protein TcasGA2_TC006628 [Tribolium castaneum] 645004819 XM_001604621.3 84 3.48119e-33 PREDICTED: Nasonia vitripennis ankyrin repeat domain-containing protein 13D (LOC100121088), mRNA -- -- -- -- Q6PD24 1509 1.1e-165 Ankyrin repeat domain-containing protein 13D OS=Mus musculus GN=Ankrd13d PE=2 SV=2 PF15306//PF00023 LIN37//Ankyrin repeat GO:0007049 cell cycle GO:0005515 protein binding GO:0017053 transcriptional repressor complex KOG0522 Ankyrin repeat protein Cluster-8309.44483 BF_2 164.00 13.33 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44485 BF_2 143.81 2.11 3140 270016830 EFA13276.1 858 6.6e-89 hypothetical protein TcasGA2_TC016027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 552 8.2e-55 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.44486 BF_2 238.23 4.56 2474 270003787 EFA00235.1 3339 0.0e+00 hypothetical protein TcasGA2_TC003063 [Tribolium castaneum] 642915737 XM_008192562.1 745 0 PREDICTED: Tribolium castaneum kalirin (LOC656919), transcript variant X3, mRNA K08810 TRIO triple functional domain protein http://www.genome.jp/dbget-bin/www_bget?ko:K08810 Q0KL02 1708 5.8e-189 Triple functional domain protein OS=Mus musculus GN=Trio PE=1 SV=3 PF00435//PF11896//PF09589 Spectrin repeat//Domain of unknown function (DUF3416)//HrpA pilus formation protein GO:0009405//GO:0005975 pathogenesis//carbohydrate metabolic process GO:0004553//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//protein binding GO:0005615 extracellular space KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.44487 BF_2 29.90 0.43 3210 642917272 XP_008199229.1 300 3.4e-24 PREDICTED: UNC93-like protein [Tribolium castaneum]>gi|642917274|ref|XP_008199230.1| PREDICTED: UNC93-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 239 1.7e-18 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006525//GO:0006560//GO:0071436//GO:0006090//GO:0006814 arginine metabolic process//proline metabolic process//sodium ion export//pyruvate metabolic process//sodium ion transport GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.44488 BF_2 1943.54 24.94 3547 189234051 XP_001809969.1 2712 7.7e-304 PREDICTED: solute carrier family 12 member 8 [Tribolium castaneum]>gi|270014477|gb|EFA10925.1| hypothetical protein TcasGA2_TC001752 [Tribolium castaneum] -- -- -- -- -- K14428 SLC12A8, CCC9 solute carrier family 12 (potassium/chloride transporters), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14428 Q6A4L1 1040 2.4e-111 Solute carrier family 12 member 8 OS=Xenopus laevis GN=slc12a8 PE=2 SV=1 PF02535//PF00324//PF13520 ZIP Zinc transporter//Amino acid permease//Amino acid permease GO:0030001//GO:0006865//GO:0055085//GO:0006810//GO:0003333 metal ion transport//amino acid transport//transmembrane transport//transport//amino acid transmembrane transport GO:0015171//GO:0046873 amino acid transmembrane transporter activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.44489 BF_2 134.46 1.52 3990 189234051 XP_001809969.1 2156 2.6e-239 PREDICTED: solute carrier family 12 member 8 [Tribolium castaneum]>gi|270014477|gb|EFA10925.1| hypothetical protein TcasGA2_TC001752 [Tribolium castaneum] -- -- -- -- -- K14428 SLC12A8, CCC9 solute carrier family 12 (potassium/chloride transporters), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14428 Q6A4L1 829 7.9e-87 Solute carrier family 12 member 8 OS=Xenopus laevis GN=slc12a8 PE=2 SV=1 PF00324//PF02535//PF13520 Amino acid permease//ZIP Zinc transporter//Amino acid permease GO:0030001//GO:0006865//GO:0055085//GO:0006810//GO:0003333 metal ion transport//amino acid transport//transmembrane transport//transport//amino acid transmembrane transport GO:0015171//GO:0046873 amino acid transmembrane transporter activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.44491 BF_2 227.35 2.44 4190 805759384 XP_012151679.1 1158 1.4e-123 PREDICTED: protein KRI1 homolog [Megachile rotundata] 820856991 XR_001112512.1 101 1.36129e-42 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA K14786 KRI1 protein KRI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14786 Q9VTU0 542 1.6e-53 Protein KRI1 homolog OS=Drosophila melanogaster GN=CG5645 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2409 KRR1-interacting protein involved in 40S ribosome biogenesis Cluster-8309.44492 BF_2 35.14 0.40 3951 332372885 AEE61584.1 909 1.0e-94 unknown [Dendroctonus ponderosae]>gi|478252324|gb|ENN72750.1| hypothetical protein YQE_10555, partial [Dendroctonus ponderosae]>gi|546680657|gb|ERL90883.1| hypothetical protein D910_08228 [Dendroctonus ponderosae] 820856991 XR_001112512.1 101 1.28297e-42 PREDICTED: Apis florea uncharacterized protein C1orf43 homolog (LOC100869278), transcript variant X3, misc_RNA K14786 KRI1 protein KRI1 http://www.genome.jp/dbget-bin/www_bget?ko:K14786 Q9VTU0 542 1.5e-53 Protein KRI1 homolog OS=Drosophila melanogaster GN=CG5645 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2409 KRR1-interacting protein involved in 40S ribosome biogenesis Cluster-8309.44494 BF_2 176.77 2.22 3620 642922580 XP_008193235.1 1425 1.4e-154 PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922582|ref|XP_008193236.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922584|ref|XP_008193237.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum]>gi|642922586|ref|XP_008193238.1| PREDICTED: protein AF-10 isoform X1 [Tribolium castaneum] 642922589 XM_008195018.1 167 2.40245e-79 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X6, mRNA -- -- -- -- P55197 507 1.6e-49 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00130//PF05405//PF00628//PF12678 Phorbol esters/diacylglycerol binding domain (C1 domain)//Mitochondrial ATP synthase B chain precursor (ATP-synt_B)//PHD-finger//RING-H2 zinc finger GO:0035556//GO:0015992//GO:0015986 intracellular signal transduction//proton transport//ATP synthesis coupled proton transport GO:0005515//GO:0008270//GO:0015078 protein binding//zinc ion binding//hydrogen ion transmembrane transporter activity -- -- KOG0956 PHD finger protein AF10 Cluster-8309.44495 BF_2 1669.30 12.58 5837 91078256 XP_970842.1 4504 0.0e+00 PREDICTED: importin-7 [Tribolium castaneum]>gi|270003922|gb|EFA00370.1| hypothetical protein TcasGA2_TC003212 [Tribolium castaneum] 558207907 XM_006132981.1 93 5.32307e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2891 0.0e+00 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF03810//PF05773//PF05743 Importin-beta N-terminal domain//RWD domain//UEV domain GO:0015031//GO:0006886//GO:0006464 protein transport//intracellular protein transport//cellular protein modification process GO:0008536//GO:0005515//GO:0008565 Ran GTPase binding//protein binding//protein transporter activity GO:0005643 nuclear pore KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.44499 BF_2 474.90 10.24 2228 546675643 ERL86793.1 952 5.9e-100 hypothetical protein D910_04198 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TPQ9 231 9.7e-18 Arrestin domain-containing protein 3 OS=Mus musculus GN=Arrdc3 PE=2 SV=1 PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.44501 BF_2 2066.93 18.22 5034 270006638 EFA03086.1 1933 2.3e-213 hypothetical protein TcasGA2_TC012992 [Tribolium castaneum] 642925120 XM_008195954.1 531 0 PREDICTED: Tribolium castaneum YTH domain-containing family protein 3 (LOC659651), transcript variant X1, mRNA -- -- -- -- Q8BYK6 754 5.0e-78 YTH domain-containing family protein 3 OS=Mus musculus GN=Ythdf3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1901 Uncharacterized high-glucose-regulated protein Cluster-8309.44502 BF_2 31.92 1.14 1462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44503 BF_2 113.55 1.27 4020 642923393 XP_008193730.1 1613 2.4e-176 PREDICTED: facilitated trehalose transporter Tret1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 457 1.1e-43 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF14634//PF12678//PF00097//PF11789//PF00083//PF07690//PF12861//PF01589//PF16685//PF13639 zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Sugar (and other) transporter//Major Facilitator Superfamily//Anaphase-promoting complex subunit 11 RING-H2 finger//Alphavirus E1 glycoprotein//zinc RING finger of MSL2//Ring finger domain GO:0016567//GO:0055085 protein ubiquitination//transmembrane transport GO:0004252//GO:0046872//GO:0008270//GO:0005515//GO:0061630//GO:0004842//GO:0022857 serine-type endopeptidase activity//metal ion binding//zinc ion binding//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//transmembrane transporter activity GO:0005680//GO:0055036//GO:0019028//GO:0016021 anaphase-promoting complex//virion membrane//viral capsid//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.44504 BF_2 10.00 0.57 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44505 BF_2 177.47 1.98 4043 642923393 XP_008193730.1 1613 2.4e-176 PREDICTED: facilitated trehalose transporter Tret1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A5LGM7 457 1.1e-43 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF14634//PF12678//PF00097//PF11789//PF00083//PF07690//PF12861//PF01589//PF16685//PF13639 zinc-RING finger domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Zinc-finger of the MIZ type in Nse subunit//Sugar (and other) transporter//Major Facilitator Superfamily//Anaphase-promoting complex subunit 11 RING-H2 finger//Alphavirus E1 glycoprotein//zinc RING finger of MSL2//Ring finger domain GO:0055085//GO:0016567 transmembrane transport//protein ubiquitination GO:0008270//GO:0004252//GO:0046872//GO:0022857//GO:0005515//GO:0061630//GO:0004842 zinc ion binding//serine-type endopeptidase activity//metal ion binding//transmembrane transporter activity//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity GO:0019028//GO:0016021//GO:0005680//GO:0055036 viral capsid//integral component of membrane//anaphase-promoting complex//virion membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.44506 BF_2 22.41 0.43 2487 478263721 ENN82024.1 257 2.6e-19 hypothetical protein YQE_01599, partial [Dendroctonus ponderosae]>gi|546679404|gb|ERL89875.1| hypothetical protein D910_07234, partial [Dendroctonus ponderosae] -- -- -- -- -- K00826 E2.6.1.42, ilvE branched-chain amino acid aminotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00826 Q5EA40 159 2.4e-09 Branched-chain-amino-acid aminotransferase, mitochondrial OS=Bos taurus GN=BCAT2 PE=2 SV=1 PF01063//PF05868 Amino-transferase class IV//Rotavirus major outer capsid protein VP7 GO:0008152 metabolic process GO:0003824 catalytic activity GO:0016021//GO:0019012 integral component of membrane//virion KOG0975 Branched chain aminotransferase BCAT1, pyridoxal phosphate enzymes type IV superfamily Cluster-8309.44507 BF_2 84.35 1.09 3521 328777746 XP_396692.3 823 8.5e-85 PREDICTED: roughened isoform X3 [Apis mellifera]>gi|340717290|ref|XP_003397118.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|350407287|ref|XP_003488045.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|380017382|ref|XP_003692636.1| PREDICTED: ras-like protein 3 [Apis florea]>gi|571537886|ref|XP_006558879.1| PREDICTED: roughened isoform X1 [Apis mellifera]>gi|571537889|ref|XP_006558880.1| PREDICTED: roughened isoform X2 [Apis mellifera]>gi|572258774|ref|XP_006607754.1| PREDICTED: ras-like protein 3-like isoform X1 [Apis dorsata]>gi|572258776|ref|XP_006607755.1| PREDICTED: ras-like protein 3-like isoform X2 [Apis dorsata]>gi|572258778|ref|XP_006607756.1| PREDICTED: ras-like protein 3-like isoform X3 [Apis dorsata]>gi|572258780|ref|XP_006607757.1| PREDICTED: ras-like protein 3-like isoform X4 [Apis dorsata]>gi|808126889|ref|XP_012166429.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126891|ref|XP_012166430.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|808126893|ref|XP_012166431.1| PREDICTED: ras-like protein 3 [Bombus terrestris]>gi|815906255|ref|XP_012238943.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906257|ref|XP_012238944.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|815906259|ref|XP_012238945.1| PREDICTED: ras-like protein 3 [Bombus impatiens]>gi|169668013|gb|ACA64426.1| RAS-like protein [Bombus ignitus] 642938605 XM_008201640.1 384 0 PREDICTED: Tribolium castaneum ras-like protein 3 (LOC658243), transcript variant X5, mRNA K04353 RAP1A Ras-related protein Rap-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04353 P08645 803 7.3e-84 Ras-like protein 3 OS=Drosophila melanogaster GN=R PE=2 SV=2 PF01926//PF08477//PF03193//PF00025//PF00071//PF00268 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ras family//Ribonucleotide reductase, small chain GO:0006184//GO:0009186//GO:0007264//GO:0055114 obsolete GTP catabolic process//deoxyribonucleoside diphosphate metabolic process//small GTPase mediated signal transduction//oxidation-reduction process GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.44509 BF_2 1103.05 9.48 5152 91088913 XP_973082.1 2219 1.6e-246 PREDICTED: uncharacterized protein KIAA0556-like [Tribolium castaneum] 551546037 XM_005760895.1 51 1.04535e-14 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 1376 3.8e-150 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF01507//PF07685//PF00733//PF00764//PF08131//PF02568//PF07722 Phosphoadenosine phosphosulfate reductase family//CobB/CobQ-like glutamine amidotransferase domain//Asparagine synthase//Arginosuccinate synthase//Defensin-like peptide family//Thiamine biosynthesis protein (ThiI)//Peptidase C26 GO:0006522//GO:0008152//GO:0006529//GO:0006531//GO:0006560//GO:0009236//GO:0008033//GO:0006541//GO:0006526 alanine metabolic process//metabolic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//cobalamin biosynthetic process//tRNA processing//glutamine metabolic process//arginine biosynthetic process GO:0004066//GO:0004810//GO:0003824//GO:0004055//GO:0005524//GO:0016787 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//catalytic activity//argininosuccinate synthase activity//ATP binding//hydrolase activity GO:0005576 extracellular region KOG1622 GMP synthase Cluster-8309.44513 BF_2 135.32 1.01 5886 91088913 XP_973082.1 2219 1.9e-246 PREDICTED: uncharacterized protein KIAA0556-like [Tribolium castaneum] 551546037 XM_005760895.1 51 1.19533e-14 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 1376 4.4e-150 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF01507//PF07685//PF00733//PF07722//PF02568//PF08131//PF00764 Phosphoadenosine phosphosulfate reductase family//CobB/CobQ-like glutamine amidotransferase domain//Asparagine synthase//Peptidase C26//Thiamine biosynthesis protein (ThiI)//Defensin-like peptide family//Arginosuccinate synthase GO:0006522//GO:0008152//GO:0006529//GO:0006531//GO:0006560//GO:0008033//GO:0009236//GO:0006541//GO:0006526 alanine metabolic process//metabolic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//tRNA processing//cobalamin biosynthetic process//glutamine metabolic process//arginine biosynthetic process GO:0004066//GO:0004810//GO:0003824//GO:0004055//GO:0005524//GO:0016787 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//catalytic activity//argininosuccinate synthase activity//ATP binding//hydrolase activity GO:0005576 extracellular region KOG1622 GMP synthase Cluster-8309.44514 BF_2 1177.16 49.85 1275 642931818 XP_008196746.1 1472 1.7e-160 PREDICTED: GMP synthase [glutamine-hydrolyzing] isoform X1 [Tribolium castaneum] -- -- -- -- -- K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 P49915 1114 2.3e-120 GMP synthase [glutamine-hydrolyzing] OS=Homo sapiens GN=GMPS PE=1 SV=1 PF00958 GMP synthase C terminal domain GO:0006536//GO:0006144//GO:0006164//GO:0006177 glutamate metabolic process//purine nucleobase metabolic process//purine nucleotide biosynthetic process//GMP biosynthetic process GO:0003922//GO:0005524 GMP synthase (glutamine-hydrolyzing) activity//ATP binding -- -- KOG1622 GMP synthase Cluster-8309.44517 BF_2 6686.00 34.18 8471 642911053 XP_008200620.1 8548 0.0e+00 PREDICTED: HEAT repeat-containing protein 5B isoform X2 [Tribolium castaneum] 549438536 KC282400.1 192 7.15748e-93 Leptinotarsa decemlineata clone 18-9298 disulfide-isomerase mRNA, partial cds -- -- -- -- Q9P2D3 5379 0.0e+00 HEAT repeat-containing protein 5B OS=Homo sapiens GN=HEATR5B PE=1 SV=2 PF02985//PF08785//PF00578//PF00085//PF00514 HEAT repeat//Ku C terminal domain like//AhpC/TSA family//Thioredoxin//Armadillo/beta-catenin-like repeat GO:0045454//GO:0055114 cell redox homeostasis//oxidation-reduction process GO:0016209//GO:0016491//GO:0005515//GO:0016817 antioxidant activity//oxidoreductase activity//protein binding//hydrolase activity, acting on acid anhydrides -- -- KOG0191 Thioredoxin/protein disulfide isomerase Cluster-8309.44519 BF_2 136.00 20.18 569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4452 BF_2 14.98 0.42 1765 642936377 XP_971655.2 1589 6.4e-174 PREDICTED: S1 RNA-binding domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N5C6 1100 1.3e-118 S1 RNA-binding domain-containing protein 1 OS=Homo sapiens GN=SRBD1 PE=1 SV=2 PF00575 S1 RNA binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG1856 Transcription elongation factor SPT6 Cluster-8309.44521 BF_2 43.00 4.66 673 478254979 ENN75212.1 181 4.5e-11 hypothetical protein YQE_08222, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44522 BF_2 20.47 0.35 2764 642924494 XP_008194318.1 1947 3.1e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 6.9e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.44524 BF_2 36.26 0.41 3967 642924494 XP_008194318.1 1947 4.4e-215 PREDICTED: 5'-AMP-activated protein kinase subunit gamma-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 Q91WG5 992 9.9e-106 5'-AMP-activated protein kinase subunit gamma-2 OS=Mus musculus GN=Prkag2 PE=1 SV=2 PF00829//PF04452 Ribosomal prokaryotic L21 protein//RNA methyltransferase GO:0006364 rRNA processing GO:0008168 methyltransferase activity GO:0005840 ribosome KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.44526 BF_2 336.75 2.17 6783 642937533 XP_008199086.1 1407 3.1e-152 PREDICTED: F-box only protein 9 [Tribolium castaneum] -- -- -- -- -- K10295 FBXO9 F-box protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10295 Q3ZBT2 828 1.8e-86 F-box only protein 9 OS=Bos taurus GN=FBXO9 PE=2 SV=2 PF00303//PF13414//PF03006//PF12937//PF00646//PF00515//PF13181 Thymidylate synthase//TPR repeat//Haemolysin-III related//F-box-like//F-box domain//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006206//GO:0006231 pyrimidine nucleobase metabolic process//dTMP biosynthetic process GO:0004799//GO:0005515 thymidylate synthase activity//protein binding GO:0016021 integral component of membrane KOG2997 F-box protein FBX9 Cluster-8309.44529 BF_2 221.61 5.38 2011 91089699 XP_974834.1 1210 6.4e-130 PREDICTED: SET and MYND domain-containing protein 4 [Tribolium castaneum]>gi|270011321|gb|EFA07769.1| hypothetical protein TcasGA2_TC005323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BTK5 173 4.7e-11 SET and MYND domain-containing protein 4 OS=Mus musculus GN=Smyd4 PE=2 SV=2 PF13414//PF00856 TPR repeat//SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.4453 BF_2 5.00 0.34 904 642936377 XP_971655.2 504 2.1e-48 PREDICTED: S1 RNA-binding domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q497V5 379 2.7e-35 S1 RNA-binding domain-containing protein 1 OS=Mus musculus GN=Srbd1 PE=2 SV=2 PF14641 Helix-turn-helix DNA-binding domain of SPT6 -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.44531 BF_2 53.87 0.73 3357 478250976 ENN71460.1 1093 4.0e-116 hypothetical protein YQE_11877, partial [Dendroctonus ponderosae]>gi|546682655|gb|ERL92567.1| hypothetical protein D910_09880 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P46941 324 2.4e-28 WW domain-containing protein tag-325 OS=Caenorhabditis elegans GN=tag-325 PE=3 SV=1 PF00620//PF02749 RhoGAP domain//Quinolinate phosphoribosyl transferase, N-terminal domain GO:0007165 signal transduction GO:0016763 transferase activity, transferring pentosyl groups -- -- KOG1450 Predicted Rho GTPase-activating protein Cluster-8309.44534 BF_2 429.91 10.78 1956 642930397 XP_008196382.1 1526 1.4e-166 PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930399|ref|XP_008196383.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|642930401|ref|XP_008196384.1| PREDICTED: PTB domain-containing adapter protein ced-6 [Tribolium castaneum]>gi|270010720|gb|EFA07168.1| hypothetical protein TcasGA2_TC010167 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7JUY7 636 9.3e-65 PTB domain-containing adapter protein ced-6 OS=Drosophila melanogaster GN=ced-6 PE=1 SV=1 PF00640//PF08416//PF14719 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG3536 Adaptor protein CED-6, contains PTB domain Cluster-8309.44537 BF_2 28.61 0.33 3936 642921067 XP_008192678.1 931 2.8e-97 PREDICTED: LIM domain only protein 3-like isoform X3 [Tribolium castaneum] 642921066 XM_008194456.1 286 1.84338e-145 PREDICTED: Tribolium castaneum LIM domain only protein 3-like (LOC663863), transcript variant X3, mRNA -- -- -- -- Q99MB5 570 8.4e-57 LIM domain only protein 3 OS=Rattus norvegicus GN=Lmo3 PE=2 SV=2 PF06112//PF00412 Gammaherpesvirus capsid protein//LIM domain -- -- GO:0008270 zinc ion binding GO:0019028 viral capsid -- -- Cluster-8309.44539 BF_2 20.25 0.92 1206 91089905 XP_972496.1 969 3.4e-102 PREDICTED: UDP-glucuronosyltransferase [Tribolium castaneum]>gi|270013659|gb|EFA10107.1| hypothetical protein TcasGA2_TC012286 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9XT55 485 1.9e-47 UDP-glucuronosyltransferase 2B19 OS=Macaca fascicularis GN=UGT2B19 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758//GO:0016740 transferase activity, transferring hexosyl groups//transferase activity -- -- -- -- Cluster-8309.44542 BF_2 1813.00 60.49 1541 478258647 ENN78697.1 1059 1.6e-112 hypothetical protein YQE_04869, partial [Dendroctonus ponderosae] -- -- -- -- -- K01540 ATP1B sodium/potassium-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K01540 Q24046 790 1.0e-82 Sodium/potassium-transporting ATPase subunit beta-1 OS=Drosophila melanogaster GN=nrv1 PE=1 SV=2 PF03598//PF00287 CO dehydrogenase/acetyl-CoA synthase complex beta subunit//Sodium / potassium ATPase beta chain GO:0006084//GO:0006814//GO:0015947//GO:0006813 acetyl-CoA metabolic process//sodium ion transport//methane metabolic process//potassium ion transport GO:0018492 carbon-monoxide dehydrogenase (acceptor) activity GO:0005890 sodium:potassium-exchanging ATPase complex KOG3927 Na+/K+ ATPase, beta subunit Cluster-8309.44544 BF_2 376.28 2.79 5936 478257810 ENN77953.1 2106 2.4e-233 hypothetical protein YQE_05630, partial [Dendroctonus ponderosae] -- -- -- -- -- K14833 NOC2 nucleolar complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14833 Q9VIF0 1452 6.8e-159 Nucleolar complex protein 2 homolog OS=Drosophila melanogaster GN=CG9246 PE=1 SV=1 PF01292//PF00083//PF07690 Prokaryotic cytochrome b561//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006118 transmembrane transport//obsolete electron transport GO:0022857//GO:0009055 transmembrane transporter activity//electron carrier activity GO:0016021 integral component of membrane KOG2256 Predicted protein involved in nuclear export of pre-ribosomes Cluster-8309.44547 BF_2 97.90 0.79 5498 642939895 XP_008200229.1 2703 1.3e-302 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] 657546453 XM_008280188.1 50 4.01402e-14 PREDICTED: Stegastes partitus protein tyrosine phosphatase, non-receptor type 6 (ptpn6), mRNA K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q06124 1888 1.7e-209 Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens GN=PTPN11 PE=1 SV=2 PF00782//PF03832//PF00102 Dual specificity phosphatase, catalytic domain//WSK motif//Protein-tyrosine phosphatase GO:0006605//GO:0007165//GO:0006570//GO:0006470 protein targeting//signal transduction//tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG0790 Protein tyrosine phosphatase Corkscrew and related SH2 domain enzymes Cluster-8309.44548 BF_2 415.48 5.27 3587 121583752 NP_001073568.1 1122 1.8e-119 cuticular protein analogous to peritrophins 3-D2 precursor [Tribolium castaneum]>gi|119387892|gb|ABL73931.1| obstractor D [Tribolium castaneum]>gi|270002339|gb|EEZ98786.1| hypothetical protein TcasGA2_TC001350 [Tribolium castaneum] 815806463 XM_012368582.1 219 2.95118e-108 PREDICTED: Linepithema humile chondroitin proteoglycan-2-like (LOC105673158), mRNA -- -- -- -- Q86UB9 152 2.3e-08 Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.44549 BF_2 391.00 3.88 4503 390362249 XP_001190749.2 1689 4.1e-185 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q505D1 908 6.2e-96 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF08513//PF07660//PF00023 Ankyrin repeat//LisH//Secretin and TonB N terminus short domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0019867 outer membrane -- -- Cluster-8309.44550 BF_2 86.01 0.71 5381 390362249 XP_001190749.2 1582 1.3e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 3.0e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00906//PF13606//PF01637//PF00023//PF00866 Hepatitis core antigen//Ankyrin repeat//Archaeal ATPase//Ankyrin repeat//Ring hydroxylating beta subunit GO:0055114//GO:0006725//GO:0009405 oxidation-reduction process//cellular aromatic compound metabolic process//pathogenesis GO:0005198//GO:0005515//GO:0005524//GO:0003824 structural molecule activity//protein binding//ATP binding//catalytic activity -- -- -- -- Cluster-8309.44553 BF_2 63.85 0.37 7450 642920095 XP_008192202.1 1816 1.3e-199 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 8.2539e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.2e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.44554 BF_2 108.49 0.63 7492 642920095 XP_008192202.1 1816 1.3e-199 PREDICTED: AF4/FMR2 family member 4 isoform X2 [Tribolium castaneum] 642920106 XM_008193986.1 172 8.30066e-82 PREDICTED: Tribolium castaneum AF4/FMR2 family member 4 (LOC664325), transcript variant X8, mRNA K15185 AFF4 AF4/FMR2 family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15185 B3NAM7 278 1.2e-22 AF4/FMR2 family member 4 OS=Drosophila erecta GN=lilli PE=3 SV=1 PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.44558 BF_2 111.22 2.44 2194 91076878 XP_974995.1 789 4.6e-81 PREDICTED: methionyl-tRNA formyltransferase, mitochondrial isoform X1 [Tribolium castaneum]>gi|270001958|gb|EEZ98405.1| hypothetical protein TcasGA2_TC000873 [Tribolium castaneum] -- -- -- -- -- K00604 MTFMT, fmt methionyl-tRNA formyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00604 Q96DP5 572 2.8e-57 Methionyl-tRNA formyltransferase, mitochondrial OS=Homo sapiens GN=MTFMT PE=1 SV=2 PF04281//PF00551//PF02911 Mitochondrial import receptor subunit Tom22//Formyl transferase//Formyl transferase, C-terminal domain GO:0006886//GO:0009058//GO:0008152 intracellular protein transport//biosynthetic process//metabolic process GO:0003824//GO:0016742 catalytic activity//hydroxymethyl-, formyl- and related transferase activity GO:0005741 mitochondrial outer membrane KOG3082 Methionyl-tRNA formyltransferase Cluster-8309.44559 BF_2 466.73 12.77 1816 270006519 EFA02967.1 989 2.5e-104 hypothetical protein TcasGA2_TC030640 [Tribolium castaneum] -- -- -- -- -- K17725 ETHE1 sulfur dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K17725 Q9DCM0 746 1.5e-77 Persulfide dioxygenase ETHE1, mitochondrial OS=Mus musculus GN=Ethe1 PE=1 SV=2 PF15221 Lens epithelial cell protein LEP503 GO:0007275 multicellular organismal development -- -- -- -- KOG0813 Glyoxylase Cluster-8309.44560 BF_2 125.65 3.85 1651 642924888 XP_008194085.1 710 5.0e-72 PREDICTED: nibrin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5I2W8 420 8.8e-40 Nibrin OS=Danio rerio GN=nbn PE=2 SV=2 PF00498//PF15826 FHA domain//Bcl-2-binding component 3, p53 upregulated modulator of apoptosis GO:0090200//GO:0043065//GO:0097193 positive regulation of release of cytochrome c from mitochondria//positive regulation of apoptotic process//intrinsic apoptotic signaling pathway GO:0005515 protein binding GO:0005739 mitochondrion -- -- Cluster-8309.44561 BF_2 8.62 0.37 1250 189237846 XP_974719.2 1150 3.6e-123 PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|642924610|ref|XP_008194362.1| PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|270007960|gb|EFA04408.1| hypothetical protein TcasGA2_TC014707 [Tribolium castaneum] 642924609 XM_008196140.1 249 2.12545e-125 PREDICTED: Tribolium castaneum BTB/POZ domain-containing protein 6 (LOC663586), transcript variant X2, mRNA K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 F7ASZ0 344 4.3e-31 BTB/POZ domain-containing protein 3 OS=Callithrix jacchus GN=BTBD3 PE=2 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.44562 BF_2 2107.44 56.96 1835 642924612 XP_008194363.1 2213 2.9e-246 PREDICTED: BTB/POZ domain-containing protein 6 isoform X2 [Tribolium castaneum] -- -- -- -- -- K10478 BTBD3_6 BTB/POZ domain-containing protein 3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K10478 P58545 374 2.1e-34 BTB/POZ domain-containing protein 3 OS=Mus musculus GN=Btbd3 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- KOG2075 Topoisomerase TOP1-interacting protein BTBD1 Cluster-8309.44564 BF_2 3281.65 118.46 1446 478259256 ENN79158.1 956 1.3e-100 hypothetical protein YQE_04344, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44565 BF_2 10.00 6.37 348 -- -- -- -- -- 462326012 APGK01041603.1 134 4.67309e-62 Dendroctonus ponderosae Seq01041613, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44567 BF_2 375.23 1.90 8549 270012359 EFA08807.1 1895 1.0e-208 hypothetical protein TcasGA2_TC006501 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 1.3e-81 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF13639//PF00198//PF08783//PF00097//PF01588//PF00098//PF04564//PF14634//PF02817 Ring finger domain//2-oxoacid dehydrogenases acyltransferase (catalytic domain)//DWNN domain//Zinc finger, C3HC4 type (RING finger)//Putative tRNA binding domain//Zinc knuckle//U-box domain//zinc-RING finger domain//e3 binding domain GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0000049//GO:0005515//GO:0016746//GO:0004842//GO:0003676//GO:0008270//GO:0046872 tRNA binding//protein binding//transferase activity, transferring acyl groups//ubiquitin-protein transferase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005634 nucleus KOG0557 Dihydrolipoamide acetyltransferase Cluster-8309.44568 BF_2 153.23 11.85 828 91083251 XP_974045.1 485 3.1e-46 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 780659103 XM_011694063.1 107 1.20281e-46 PREDICTED: Wasmannia auropunctata ATP-dependent RNA helicase WM6 (LOC105452708), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q5ZHZ0 436 6.1e-42 Spliceosome RNA helicase DDX39B OS=Gallus gallus GN=DDX39B PE=2 SV=1 PF00270 DEAD/DEAH box helicase -- -- GO:0008026//GO:0003676//GO:0005524 ATP-dependent helicase activity//nucleic acid binding//ATP binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.44569 BF_2 435.93 29.28 910 332376787 AEE63533.1 834 1.2e-86 unknown [Dendroctonus ponderosae]>gi|478252479|gb|ENN72901.1| hypothetical protein YQE_10471, partial [Dendroctonus ponderosae]>gi|546682599|gb|ERL92518.1| hypothetical protein D910_09831 [Dendroctonus ponderosae] 617645164 XM_007532444.1 182 2.69531e-88 PREDICTED: Erinaceus europaeus DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A (DDX39A), mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q27268 800 4.2e-84 ATP-dependent RNA helicase WM6 OS=Drosophila melanogaster GN=Hel25E PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.44570 BF_2 27.15 0.64 2070 91083251 XP_974045.1 697 2.0e-70 PREDICTED: ATP-dependent RNA helicase WM6 [Tribolium castaneum]>gi|270007718|gb|EFA04166.1| hypothetical protein TcasGA2_TC014413 [Tribolium castaneum] 442626186 NM_001273171.1 169 1.05486e-80 Drosophila melanogaster helicase at 25E (Hel25E), transcript variant D, mRNA K12812 UAP56, BAT1, SUB2 ATP-dependent RNA helicase UAP56/SUB2 http://www.genome.jp/dbget-bin/www_bget?ko:K12812 Q63413 618 1.2e-62 Spliceosome RNA helicase Ddx39b OS=Rattus norvegicus GN=Ddx39b PE=2 SV=3 PF00128//PF02391//PF04851//PF00270//PF00765 Alpha amylase, catalytic domain//MoaE protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//Autoinducer synthase GO:0005975//GO:0006777 carbohydrate metabolic process//Mo-molybdopterin cofactor biosynthetic process GO:0008026//GO:0003677//GO:0016787//GO:0016740//GO:0005524//GO:0003824//GO:0043169//GO:0003676 ATP-dependent helicase activity//DNA binding//hydrolase activity//transferase activity//ATP binding//catalytic activity//cation binding//nucleic acid binding -- -- KOG0329 ATP-dependent RNA helicase Cluster-8309.44578 BF_2 8.84 0.46 1086 357611230 EHJ67381.1 181 7.3e-11 hypothetical protein KGM_13834 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44579 BF_2 65.37 0.53 5480 642930890 XP_008196128.1 314 1.4e-25 PREDICTED: protein-methionine sulfoxide oxidase MICAL3 isoform X8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 208 1.1e-14 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44584 BF_2 669.99 7.22 4167 189239223 XP_973572.2 678 6.5e-68 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 7.75384e-75 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44586 BF_2 72.14 0.92 3569 270006797 EFA03245.1 212 6.1e-14 hypothetical protein TcasGA2_TC013178 [Tribolium castaneum] -- -- -- -- -- K13171 SRRM1, SRM160 serine/arginine repetitive matrix protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13171 Q52KI8 169 2.4e-10 Serine/arginine repetitive matrix protein 1 OS=Mus musculus GN=Srrm1 PE=1 SV=2 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2146 Splicing coactivator SRm160/300, subunit SRm160 (contains PWI domain) Cluster-8309.44588 BF_2 30.07 0.38 3563 91089227 XP_968078.1 1676 1.1e-183 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 699 8.4e-72 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF00498//PF12920 FHA domain//TcdA/TcdB pore forming domain GO:0009405 pathogenesis GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.44589 BF_2 428.98 5.57 3509 91089227 XP_968078.1 1676 1.0e-183 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 699 8.3e-72 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF00498//PF12920 FHA domain//TcdA/TcdB pore forming domain GO:0009405 pathogenesis GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.44591 BF_2 5.00 1.33 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44592 BF_2 31.96 0.36 3987 642910866 XP_001813884.2 3464 0.0e+00 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] -- -- -- -- -- K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 Q8TEK3 1321 7.1e-144 Histone-lysine N-methyltransferase, H3 lysine-79 specific OS=Homo sapiens GN=DOT1L PE=1 SV=2 PF08123//PF02390//PF00103 Histone methylation protein DOT1//Putative methyltransferase//Somatotropin hormone family GO:0007165//GO:0009451//GO:0006479//GO:0006554//GO:0008033//GO:0006400 signal transduction//RNA modification//protein methylation//lysine catabolic process//tRNA processing//tRNA modification GO:0018024//GO:0005179//GO:0008176 histone-lysine N-methyltransferase activity//hormone activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005576 extracellular region KOG3924 Putative protein methyltransferase involved in meiosis and transcriptional silencing (Dot1) Cluster-8309.44595 BF_2 111.47 0.83 5904 642930905 XP_008196134.1 432 3.1e-39 PREDICTED: TRAF-type zinc finger domain-containing protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01001 Hepatitis C virus non-structural protein NS4b GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0017111//GO:0004252//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//serine-type endopeptidase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.44601 BF_2 448.00 2.09 9243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12422 Condensin II non structural maintenance of chromosomes subunit -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.44602 BF_2 533.65 5.16 4617 255918127 NP_001157610.1 1687 7.2e-185 tramtrack [Tribolium castaneum]>gi|642921896|ref|XP_008192935.1| PREDICTED: tramtrack isoform X1 [Tribolium castaneum] 751794272 XR_852685.1 49 1.21084e-13 PREDICTED: Bactrocera dorsalis polyhomeotic-proximal chromatin protein-like (LOC105228656), transcript variant X5, misc_RNA K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 578 1.2e-57 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF02178//PF00096//PF13465//PF13912//PF00651 AT hook motif//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//BTB/POZ domain -- -- GO:0005515//GO:0046872//GO:0003677 protein binding//metal ion binding//DNA binding -- -- -- -- Cluster-8309.44603 BF_2 75.66 0.77 4388 255918127 NP_001157610.1 1687 6.9e-185 tramtrack [Tribolium castaneum]>gi|642921896|ref|XP_008192935.1| PREDICTED: tramtrack isoform X1 [Tribolium castaneum] 751794272 XR_852685.1 49 1.15031e-13 PREDICTED: Bactrocera dorsalis polyhomeotic-proximal chromatin protein-like (LOC105228656), transcript variant X5, misc_RNA K09237 TTK tramtrack http://www.genome.jp/dbget-bin/www_bget?ko:K09237 P17789 578 1.1e-57 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF02178//PF13465//PF00096//PF13912//PF00651 AT hook motif//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BTB/POZ domain -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.44604 BF_2 137.83 2.93 2258 270009876 EFA06324.1 1586 1.8e-173 hypothetical protein TcasGA2_TC009195 [Tribolium castaneum] 704338400 XM_010176089.1 39 2.12897e-08 PREDICTED: Caprimulgus carolinensis salvador family WW domain containing protein 1 (SAV1), mRNA K16686 SAV1, Sav scaffold protein salvador http://www.genome.jp/dbget-bin/www_bget?ko:K16686 Q9H4B6 559 9.1e-56 Protein salvador homolog 1 OS=Homo sapiens GN=SAV1 PE=1 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.44607 BF_2 14.93 0.74 1131 642921248 XP_969543.2 563 3.8e-55 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 Q7KQM6 245 1.2e-19 PERQ amino acid-rich with GYF domain-containing protein CG11148 OS=Drosophila melanogaster GN=CG11148 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44608 BF_2 13.00 0.45 1499 478250837 ENN71327.1 180 1.3e-10 hypothetical protein YQE_11987, partial [Dendroctonus ponderosae] 642921251 XM_008194562.1 101 4.79912e-43 PREDICTED: Tribolium castaneum PERQ amino acid-rich with GYF domain-containing protein 2 (LOC658036), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF12297 Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- -- -- -- -- Cluster-8309.44611 BF_2 54.54 1.71 1625 546676387 ERL87409.1 298 2.9e-24 hypothetical protein D910_04804 [Dendroctonus ponderosae] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 P08074 219 1.8e-16 Carbonyl reductase [NADPH] 2 OS=Mus musculus GN=Cbr2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.44613 BF_2 2.00 2.39 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44616 BF_2 499.66 4.44 4993 642938298 XP_008192776.1 2305 1.7e-256 PREDICTED: late secretory pathway protein AVL9 homolog [Tribolium castaneum] 820839237 XM_012495150.1 168 9.23864e-80 PREDICTED: Apis florea late secretory pathway protein AVL9 homolog (LOC100871294), mRNA -- -- -- -- Q80U56 1230 3.2e-133 Late secretory pathway protein AVL9 homolog OS=Mus musculus GN=Avl9 PE=2 SV=2 PF01767 Birnavirus VP3 protein -- -- GO:0005198 structural molecule activity -- -- KOG3823 Uncharacterized conserved protein Cluster-8309.44618 BF_2 159.42 0.90 7715 260436903 NP_001159498.1 879 5.9e-91 U-box domain containing 5 [Tribolium castaneum] -- -- -- -- -- K10600 UBOX5, UIP5 U-box domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10600 Q925F4 318 2.8e-27 RING finger protein 37 OS=Mus musculus GN=Ubox5 PE=1 SV=2 PF04564//PF14634 U-box domain//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0005515//GO:0004842 zinc ion binding//protein binding//ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.44625 BF_2 142.46 2.06 3176 546681102 ERL91258.1 1088 1.4e-115 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P34410 177 2.5e-11 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF01573 Bromovirus movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0044156 host cell junction -- -- Cluster-8309.44626 BF_2 211.46 8.10 1379 478260273 ENN80025.1 238 2.3e-17 hypothetical protein YQE_03502, partial [Dendroctonus ponderosae] -- -- -- -- -- K03424 tatD TatD DNase family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03424 -- -- -- -- PF01026 TatD related DNase GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- -- -- Cluster-8309.44627 BF_2 122.47 0.64 8261 642919073 XP_008191722.1 1583 1.5e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.4e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.44629 BF_2 92.21 0.50 7976 642919073 XP_008191722.1 1583 1.4e-172 PREDICTED: MAP kinase-activating death domain protein isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXY2 1281 6.1e-139 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3570 MAPK-activating protein DENN Cluster-8309.44630 BF_2 176.54 2.32 3469 817051906 XP_012253468.1 1791 4.7e-197 PREDICTED: autophagy-related protein 16-1 isoform X2 [Athalia rosae] -- -- -- -- -- K17890 ATG16L autophagy-related protein 16, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K17890 Q676U5 920 1.9e-97 Autophagy-related protein 16-1 OS=Homo sapiens GN=ATG16L1 PE=1 SV=2 PF00105//PF00400//PF05837//PF08702 Zinc finger, C4 type (two domains)//WD domain, G-beta repeat//Centromere protein H (CENP-H)//Fibrinogen alpha/beta chain family GO:0030168//GO:0006355//GO:0051258//GO:0051382//GO:0007165 platelet activation//regulation of transcription, DNA-templated//protein polymerization//kinetochore assembly//signal transduction GO:0003700//GO:0005102//GO:0008270//GO:0030674//GO:0043565//GO:0005515 transcription factor activity, sequence-specific DNA binding//receptor binding//zinc ion binding//protein binding, bridging//sequence-specific DNA binding//protein binding GO:0005577//GO:0000776//GO:0005667//GO:0005634 fibrinogen complex//kinetochore//transcription factor complex//nucleus KOG0288 WD40 repeat protein TipD Cluster-8309.44631 BF_2 64.86 1.17 2605 642921092 XP_008192688.1 1665 1.4e-182 PREDICTED: mediator of RNA polymerase II transcription subunit 25 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15168 MED25 mediator of RNA polymerase II transcription subunit 25 http://www.genome.jp/dbget-bin/www_bget?ko:K15168 Q9VDR1 538 2.9e-53 Mediator of RNA polymerase II transcription subunit 25 OS=Drosophila melanogaster GN=MED25 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44632 BF_2 2044.35 25.46 3646 642928913 XP_971104.2 1611 3.7e-176 PREDICTED: FK506-binding protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.44633 BF_2 23.00 0.36 2926 91083807 XP_973296.1 1994 1.2e-220 PREDICTED: organic cation transporter protein isoform X1 [Tribolium castaneum]>gi|270007927|gb|EFA04375.1| hypothetical protein TcasGA2_TC014673 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 794 6.7e-83 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF03839//PF00083//PF07690 Translocation protein Sec62//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0015031 transmembrane transport//protein transport GO:0008565//GO:0022857 protein transporter activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.44634 BF_2 420.60 4.02 4660 270010422 EFA06870.1 1347 1.9e-145 hypothetical protein TcasGA2_TC009815 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05891 AdoMet dependent proline di-methyltransferase GO:0006480 N-terminal protein amino acid methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.44635 BF_2 492.12 1.91 11053 642934936 XP_008195867.1 3128 0.0e+00 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 205 5.54741e-100 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 548 8.4e-54 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF05225//PF05197 helix-turn-helix, Psq domain//TRIC channel GO:0015672//GO:0006812 monovalent inorganic cation transport//cation transport GO:0003677//GO:0005261 DNA binding//cation channel activity GO:0016020 membrane KOG4565 E93 protein involved in programmed cell death, putative transcription regulator Cluster-8309.44636 BF_2 939.80 10.73 3952 478258615 ENN78665.1 504 9.3e-48 hypothetical protein YQE_04837, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08720 Influenza C hemagglutinin stalk GO:0007165//GO:0019064 signal transduction//fusion of virus membrane with host plasma membrane GO:0046789 host cell surface receptor binding GO:0009986//GO:0019031 cell surface//viral envelope -- -- Cluster-8309.44637 BF_2 253.23 1.50 7357 642911815 XP_008200755.1 6657 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 596 1.5e-59 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.44638 BF_2 292.34 1.55 8197 642920751 XP_008192546.1 1457 6.0e-158 PREDICTED: pre-mRNA cleavage complex 2 protein Pcf11 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 446 4.2e-42 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 PF08916 Phenylalanine zipper GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0004871 signal transducer activity -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.44639 BF_2 52.61 1.16 2180 780687510 XP_011698854.1 345 1.4e-29 PREDICTED: uncharacterized protein LOC105456480 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.44640 BF_2 114.67 2.91 1933 332375618 AEE62950.1 1358 4.3e-147 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02175 BRN putative enzyme (brainiac) http://www.genome.jp/dbget-bin/www_bget?ko:K02175 Q24157 635 1.2e-64 Beta-1,3-galactosyltransferase brn OS=Drosophila melanogaster GN=brn PE=2 SV=2 PF12919//PF01762//PF02434//PF11365//PF05557 TcdA/TcdB catalytic glycosyltransferase domain//Galactosyltransferase//Fringe-like//Protein of unknown function (DUF3166)//Mitotic checkpoint protein GO:0007094//GO:0006486//GO:0010506 mitotic spindle assembly checkpoint//protein glycosylation//regulation of autophagy GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0005615//GO:0016020 extracellular space//membrane -- -- Cluster-8309.44641 BF_2 278.84 6.53 2073 642929609 XP_008195902.1 2320 1.3e-258 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] 642929608 XM_008197680.1 221 1.30976e-109 PREDICTED: Tribolium castaneum FAS-associated factor 1 (LOC664346), mRNA -- -- -- -- Q9UNN5 1010 4.2e-108 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF09226//PF00240//PF00789 Restriction endonuclease HincII//Ubiquitin family//UBX domain GO:0006308//GO:0009307 DNA catabolic process//DNA restriction-modification system GO:0005515//GO:0003677//GO:0009036 protein binding//DNA binding//Type II site-specific deoxyribonuclease activity GO:0009359 Type II site-specific deoxyribonuclease complex KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.44646 BF_2 511.29 30.17 996 91090021 XP_967356.1 957 6.9e-101 PREDICTED: peroxiredoxin-1 [Tribolium castaneum]>gi|270014285|gb|EFA10733.1| hypothetical protein TcasGA2_TC012328 [Tribolium castaneum] -- -- -- -- -- K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9Z0V6 678 6.4e-70 Thioredoxin-dependent peroxide reductase, mitochondrial OS=Rattus norvegicus GN=Prdx3 PE=1 SV=2 PF10417//PF00578//PF08534 C-terminal domain of 1-Cys peroxiredoxin//AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0016209//GO:0051920//GO:0016491 antioxidant activity//peroxiredoxin activity//oxidoreductase activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.44648 BF_2 111.43 0.67 7239 189241670 XP_001807691.1 252 2.8e-18 PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum]>gi|642937361|ref|XP_008198805.1| PREDICTED: inositol monophosphatase 2-like [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 Q9M8S8 232 2.4e-17 Inositol-phosphate phosphatase OS=Arabidopsis thaliana GN=VTC4 PE=1 SV=1 PF03664//PF04159//PF02935//PF00459//PF05739 Glycosyl hydrolase family 62//NB glycoprotein//Cytochrome c oxidase subunit VIIc//Inositol monophosphatase family//SNARE domain GO:0009117//GO:0006123//GO:0046373//GO:0015992//GO:0046854//GO:0005975 nucleotide metabolic process//mitochondrial electron transport, cytochrome c to oxygen//L-arabinose metabolic process//proton transport//phosphatidylinositol phosphorylation//carbohydrate metabolic process GO:0046556//GO:0005515//GO:0004129 alpha-L-arabinofuranosidase activity//protein binding//cytochrome-c oxidase activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2951 Inositol monophosphatase Cluster-8309.44656 BF_2 47.16 0.85 2603 642927014 XP_001810799.2 529 7.7e-51 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9J0 162 1.1e-09 Peroxisomal leader peptide-processing protease OS=Homo sapiens GN=TYSND1 PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.44657 BF_2 161.06 1.87 3893 642922648 XP_008193260.1 2324 8.3e-259 PREDICTED: coiled-coil and C2 domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K18260 CC2D1 coiled-coil and C2 domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18260 Q29M42 1636 2.1e-180 Coiled-coil and C2 domain-containing protein 1-like OS=Drosophila pseudoobscura pseudoobscura GN=GA18377 PE=3 SV=2 PF00168//PF04097//PF00711 C2 domain//Nup93/Nic96//Beta defensin GO:0006952//GO:0006810 defense response//transport GO:0005515 protein binding GO:0005576//GO:0005643 extracellular region//nuclear pore KOG3837 Uncharacterized conserved protein, contains DM14 and C2 domains Cluster-8309.44658 BF_2 36.14 0.39 4191 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44659 BF_2 224.77 3.67 2851 642930150 XP_008196273.1 1713 4.3e-188 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X7 [Tribolium castaneum] 189164165 EU545256.1 376 0 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1233 8.1e-134 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.44660 BF_2 30.39 0.47 2998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44661 BF_2 22.20 0.40 2629 531447909 AGT57849.1 911 3.9e-95 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 603 8.4e-61 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067//PF04083//PF00328 Cytochrome P450//Partial alpha/beta-hydrolase lipase region//Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0055114//GO:0019497//GO:0006629 riboflavin metabolic process//oxidation-reduction process//hexachlorocyclohexane metabolic process//lipid metabolic process GO:0003993//GO:0020037//GO:0005506//GO:0016705 acid phosphatase activity//heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.44662 BF_2 261.05 3.82 3149 478257994 ENN78132.1 1444 7.4e-157 hypothetical protein YQE_05286, partial [Dendroctonus ponderosae] 815908496 XM_003488754.2 48 2.95938e-13 PREDICTED: Bombus impatiens protein SEC13 homolog (LOC100746611), mRNA K14004 SEC13 protein transport protein SEC13 http://www.genome.jp/dbget-bin/www_bget?ko:K14004 P55735 1099 3.1e-118 Protein SEC13 homolog OS=Homo sapiens GN=SEC13 PE=1 SV=3 PF00400//PF00023//PF00097//PF13606//PF14634//PF13639//PF16685 WD domain, G-beta repeat//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat//zinc-RING finger domain//Ring finger domain//zinc RING finger of MSL2 -- -- GO:0061630//GO:0005515//GO:0046872//GO:0008270 ubiquitin protein ligase activity//protein binding//metal ion binding//zinc ion binding -- -- KOG1332 Vesicle coat complex COPII, subunit SEC13 Cluster-8309.44664 BF_2 216.99 0.65 14305 91089729 XP_975072.1 3148 0.0e+00 PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|642933644|ref|XP_008197508.1| PREDICTED: H(+)/Cl(-) exchange transporter 7 [Tribolium castaneum]>gi|270011308|gb|EFA07756.1| hypothetical protein TcasGA2_TC005310 [Tribolium castaneum] -- -- -- -- -- K05016 CLCN7 chloride channel 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05016 P51798 1839 2.2e-203 H(+)/Cl(-) exchange transporter 7 OS=Homo sapiens GN=CLCN7 PE=1 SV=2 PF00170//PF00654//PF04111//PF15191//PF00769//PF15898//PF10473//PF05024//PF15036//PF13851//PF00709//PF03328//PF08702//PF02183//PF13326//PF09726//PF05837//PF07926 bZIP transcription factor//Voltage gated chloride channel//Autophagy protein Apg6//Synaptonemal complex central element protein 3//Ezrin/radixin/moesin family//cGMP-dependent protein kinase interacting domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//N-acetylglucosaminyl transferase component (Gpi1)//Interleukin 34//Growth-arrest specific micro-tubule binding//Adenylosuccinate synthetase//HpcH/HpaI aldolase/citrate lyase family//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper//Photosystem II Pbs27//Transmembrane protein//Centromere protein H (CENP-H)//TPR/MLP1/MLP2-like protein GO:0006144//GO:0006821//GO:0007130//GO:0040007//GO:0006506//GO:0006522//GO:0051258//GO:0006914//GO:0007165//GO:0007283//GO:0008284//GO:0006355//GO:0007131//GO:0006531//GO:0048870//GO:0008283//GO:0001934//GO:0010207//GO:0030168//GO:0006164//GO:0051382//GO:0055085//GO:0006606 purine nucleobase metabolic process//chloride transport//synaptonemal complex assembly//growth//GPI anchor biosynthetic process//alanine metabolic process//protein polymerization//autophagy//signal transduction//spermatogenesis//positive regulation of cell proliferation//regulation of transcription, DNA-templated//reciprocal meiotic recombination//aspartate metabolic process//cell motility//cell proliferation//positive regulation of protein phosphorylation//photosystem II assembly//platelet activation//purine nucleotide biosynthetic process//kinetochore assembly//transmembrane transport//protein import into nucleus GO:0017176//GO:0003824//GO:0042803//GO:0005525//GO:0043565//GO:0005247//GO:0019901//GO:0008092//GO:0030674//GO:0004019//GO:0008134//GO:0045502//GO:0003700//GO:0005157//GO:0005102 phosphatidylinositol N-acetylglucosaminyltransferase activity//catalytic activity//protein homodimerization activity//GTP binding//sequence-specific DNA binding//voltage-gated chloride channel activity//protein kinase binding//cytoskeletal protein binding//protein binding, bridging//adenylosuccinate synthase activity//transcription factor binding//dynein binding//transcription factor activity, sequence-specific DNA binding//macrophage colony-stimulating factor receptor binding//receptor binding GO:0016020//GO:0016021//GO:0031514//GO:0005737//GO:0005667//GO:0030286//GO:0000776//GO:0019898//GO:0005615//GO:0005577 membrane//integral component of membrane//motile cilium//cytoplasm//transcription factor complex//dynein complex//kinetochore//extrinsic component of membrane//extracellular space//fibrinogen complex KOG0474 Cl- channel CLC-7 and related proteins (CLC superfamily) Cluster-8309.44665 BF_2 12.21 0.38 1639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44669 BF_2 651.36 5.29 5437 189240413 XP_969795.2 2244 2.2e-249 PREDICTED: forkhead box protein K1 [Tribolium castaneum]>gi|270011459|gb|EFA07907.1| hypothetical protein TcasGA2_TC005482 [Tribolium castaneum] 642932965 XM_964702.3 346 1.13034e-178 PREDICTED: Tribolium castaneum forkhead box protein K1 (LOC658300), mRNA K09404 FOXK forkhead box protein K http://www.genome.jp/dbget-bin/www_bget?ko:K09404 P42128 1096 1.2e-117 Forkhead box protein K1 OS=Mus musculus GN=Foxk1 PE=1 SV=2 PF00250//PF00498 Forkhead domain//FHA domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0005515//GO:0003700 sequence-specific DNA binding//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.4467 BF_2 5.00 1.16 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44673 BF_2 181.04 3.44 2488 91089449 XP_967843.1 2043 2.0e-226 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 [Tribolium castaneum]>gi|270011408|gb|EFA07856.1| hypothetical protein TcasGA2_TC005426 [Tribolium castaneum] -- -- -- -- -- K14440 SMARCAL1, HARP SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14440 Q9VMX6 1255 2.0e-136 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 OS=Drosophila melanogaster GN=Marcal1 PE=1 SV=2 PF13949//PF04851//PF00176 ALIX V-shaped domain binding to HIV//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain GO:0016568 chromatin modification GO:0005515//GO:0003677//GO:0016787//GO:0004386//GO:0005524 protein binding//DNA binding//hydrolase activity//helicase activity//ATP binding GO:0005634 nucleus KOG1000 Chromatin remodeling protein HARP/SMARCAL1, DEAD-box superfamily Cluster-8309.44674 BF_2 97.84 1.90 2440 189238895 XP_966473.2 1135 3.9e-121 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 317 1.1e-27 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF13855//PF00128 Leucine rich repeat//Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169//GO:0005515 catalytic activity//cation binding//protein binding -- -- KOG2123 Uncharacterized conserved protein Cluster-8309.44676 BF_2 168.89 1.51 4971 642925814 XP_970128.3 570 2.6e-55 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 405 1.4e-37 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01370//PF02737//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//short chain dehydrogenase GO:0006574//GO:0006550//GO:0008152//GO:0006633//GO:0018874//GO:0006568//GO:0006631//GO:0006552//GO:0006554//GO:0055114 valine catabolic process//isoleucine catabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//tryptophan metabolic process//fatty acid metabolic process//leucine catabolic process//lysine catabolic process//oxidation-reduction process GO:0050662//GO:0003824//GO:0016491//GO:0003857 coenzyme binding//catalytic activity//oxidoreductase activity//3-hydroxyacyl-CoA dehydrogenase activity -- -- -- -- Cluster-8309.44677 BF_2 51.29 1.64 1593 642912944 XP_008201318.1 785 9.7e-81 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P80034 507 6.9e-50 Antichymotrypsin-2 OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44679 BF_2 125.36 2.61 2300 -- -- -- -- -- 462381300 APGK01022056.1 51 4.62951e-15 Dendroctonus ponderosae Seq01022066, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44680 BF_2 10.00 52.99 251 795517215 XP_011712761.1 453 4.8e-43 PREDICTED: tubulin alpha-8 chain isoform X2 [Macaca nemestrina] 768423887 XM_011554570.1 186 4.00968e-91 PREDICTED: Plutella xylostella tubulin alpha chain (LOC105384350), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q32KN8 453 2.0e-44 Tubulin alpha-3 chain OS=Bos taurus GN=TUBA3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44683 BF_2 546.62 5.19 4693 189241196 XP_001810857.1 3678 0.0e+00 PREDICTED: zinc finger protein 91 [Tribolium castaneum]>gi|270013967|gb|EFA10415.1| hypothetical protein TcasGA2_TC012655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51523 616 4.7e-62 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF00096//PF02112//PF13912//PF01258 Zinc-finger double domain//Zinc finger, C2H2 type//cAMP phosphodiesterases class-II//C2H2-type zinc finger//Prokaryotic dksA/traR C4-type zinc finger GO:0006198 cAMP catabolic process GO:0046872//GO:0004115//GO:0008270//GO:0005488 metal ion binding//3',5'-cyclic-AMP phosphodiesterase activity//zinc ion binding//binding -- -- -- -- Cluster-8309.44685 BF_2 900.45 4.61 8465 642910377 XP_971554.2 7752 0.0e+00 PREDICTED: uncharacterized protein LOC660207 isoform X3 [Tribolium castaneum] 194747504 XM_001956156.1 230 5.37486e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q9CPW0 626 5.8e-63 Contactin-associated protein-like 2 OS=Mus musculus GN=Cntnap2 PE=1 SV=2 PF02432//PF10192//PF00014//PF00008 Fimbrial, major and minor subunit//Rhodopsin-like GPCR transmembrane domain//Kunitz/Bovine pancreatic trypsin inhibitor domain//EGF-like domain GO:0007155//GO:0007186//GO:0019236 cell adhesion//G-protein coupled receptor signaling pathway//response to pheromone GO:0004867//GO:0005515 serine-type endopeptidase inhibitor activity//protein binding GO:0009289 pilus -- -- Cluster-8309.44686 BF_2 18.36 0.37 2366 795020727 XP_011860021.1 875 5.3e-91 PREDICTED: transposable element P transposase isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 310 7.2e-27 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44688 BF_2 13.99 1.24 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44689 BF_2 18.05 0.43 2031 817076849 XP_012260720.1 761 7.5e-78 PREDICTED: beclin 1-associated autophagy-related key regulator isoform X1 [Athalia rosae] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 Q6ZNE5 477 2.6e-46 Beclin 1-associated autophagy-related key regulator OS=Homo sapiens GN=ATG14 PE=1 SV=1 PF10186//PF00643 Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0010508 positive regulation of autophagy GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.44690 BF_2 116.31 2.99 1917 91088681 XP_974930.1 1028 7.8e-109 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JFV8 482 6.6e-47 Synaptic vesicle membrane protein VAT-1 homolog OS=Danio rerio GN=vat1 PE=2 SV=1 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.44695 BF_2 1350.93 7.30 8025 91085649 XP_970922.1 6731 0.0e+00 PREDICTED: CD109 antigen [Tribolium castaneum]>gi|270011037|gb|EFA07485.1| hypothetical protein TcasGA2_TC009375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R422 759 2.1e-78 CD109 antigen OS=Mus musculus GN=Cd109 PE=2 SV=1 PF00057//PF00432//PF00207//PF07678//PF02033//PF07677//PF01835 Low-density lipoprotein receptor domain class A//Prenyltransferase and squalene oxidase repeat//Alpha-2-macroglobulin family//A-macroglobulin complement component//Ribosome-binding factor A//A-macroglobulin receptor//MG2 domain GO:0006364//GO:0010951 rRNA processing//negative regulation of endopeptidase activity GO:0003824//GO:0004866//GO:0005515 catalytic activity//endopeptidase inhibitor activity//protein binding GO:0005576//GO:0005615 extracellular region//extracellular space KOG1366 Alpha-macroglobulin Cluster-8309.44698 BF_2 63.89 0.38 7241 642930298 XP_008196335.1 3056 0.0e+00 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1 [Tribolium castaneum] 642930305 XM_008198117.1 1318 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 1577 2.7e-173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF00520//PF01676 Ion transport protein//Metalloenzyme superfamily GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0046872//GO:0005216//GO:0003824 metal ion binding//ion channel activity//catalytic activity GO:0016020 membrane -- -- Cluster-8309.44699 BF_2 720.72 4.43 7096 642930298 XP_008196335.1 3056 0.0e+00 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1 [Tribolium castaneum] 642930305 XM_008198117.1 1318 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 1577 2.6e-173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF00520//PF01676 Ion transport protein//Metalloenzyme superfamily GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0046872//GO:0003824//GO:0005216 metal ion binding//catalytic activity//ion channel activity GO:0016020 membrane -- -- Cluster-8309.44701 BF_2 47.54 1.43 1680 189239358 XP_974445.2 1222 2.2e-131 PREDICTED: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [Tribolium castaneum] 817088660 XM_012411735.1 54 7.22674e-17 PREDICTED: Athalia rosae tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (LOC105692505), transcript variant X2, mRNA K05545 DUS4 tRNA-dihydrouridine synthase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05545 Q32M08 710 2.1e-73 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus4l PE=2 SV=1 PF00977//PF01207 Histidine biosynthesis protein//Dihydrouridine synthase (Dus) GO:0008033//GO:0055114//GO:0000105 tRNA processing//oxidation-reduction process//histidine biosynthetic process GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.44703 BF_2 117.00 12.06 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44704 BF_2 58.16 0.66 3966 642917429 XP_008191194.1 1648 2.1e-180 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1L258 1320 9.2e-144 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF01565//PF02913//PF08558 FAD binding domain//FAD linked oxidases, C-terminal domain//Telomere repeat binding factor (TRF) GO:0055114 oxidation-reduction process GO:0016491//GO:0042162//GO:0050660//GO:0003824//GO:0042803 oxidoreductase activity//telomeric DNA binding//flavin adenine dinucleotide binding//catalytic activity//protein homodimerization activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.44705 BF_2 15.00 0.58 1376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44711 BF_2 67.16 0.51 5770 91091932 XP_966409.1 1977 2.1e-218 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 827536550 XM_004921667.2 136 6.56975e-62 PREDICTED: Bombyx mori structural maintenance of chromosomes protein 3 (LOC101736252), mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O93309 1082 5.3e-116 Structural maintenance of chromosomes protein 3 OS=Xenopus laevis GN=smc3 PE=1 SV=2 PF04210//PF05440//PF00614//PF05531//PF13304 Tetrahydromethanopterin S-methyltransferase, subunit G//Tetrahydromethanopterin S-methyltransferase subunit B//Phospholipase D Active site motif//Nucleopolyhedrovirus P10 protein//AAA domain, putative AbiEii toxin, Type IV TA system GO:0030261//GO:0006310//GO:0007062//GO:0046656//GO:0006281//GO:0015948 chromosome condensation//DNA recombination//sister chromatid cohesion//folic acid biosynthetic process//DNA repair//methanogenesis GO:0030269//GO:0005524//GO:0003824 tetrahydromethanopterin S-methyltransferase activity//ATP binding//catalytic activity GO:0005694//GO:0019028//GO:0005634//GO:0016021 chromosome//viral capsid//nucleus//integral component of membrane KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.44713 BF_2 589.37 4.86 5359 91091932 XP_966409.1 1977 2.0e-218 PREDICTED: structural maintenance of chromosomes protein 3 [Tribolium castaneum]>gi|270000783|gb|EEZ97230.1| hypothetical protein TcasGA2_TC011028 [Tribolium castaneum] 827536550 XM_004921667.2 136 6.09885e-62 PREDICTED: Bombyx mori structural maintenance of chromosomes protein 3 (LOC101736252), mRNA K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O93309 1082 4.9e-116 Structural maintenance of chromosomes protein 3 OS=Xenopus laevis GN=smc3 PE=1 SV=2 PF13304//PF05531//PF00614//PF04210//PF05440 AAA domain, putative AbiEii toxin, Type IV TA system//Nucleopolyhedrovirus P10 protein//Phospholipase D Active site motif//Tetrahydromethanopterin S-methyltransferase, subunit G//Tetrahydromethanopterin S-methyltransferase subunit B GO:0006281//GO:0046656//GO:0015948//GO:0030261//GO:0007062//GO:0006310 DNA repair//folic acid biosynthetic process//methanogenesis//chromosome condensation//sister chromatid cohesion//DNA recombination GO:0005524//GO:0003824//GO:0030269 ATP binding//catalytic activity//tetrahydromethanopterin S-methyltransferase activity GO:0016021//GO:0005634//GO:0019028//GO:0005694 integral component of membrane//nucleus//viral capsid//chromosome KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-8309.44715 BF_2 152.93 1.27 5339 270002209 EEZ98656.1 2306 1.4e-256 hypothetical protein TcasGA2_TC001185 [Tribolium castaneum] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1289 4.9e-140 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.44716 BF_2 133.54 4.03 1675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44717 BF_2 180.88 1.91 4239 642924682 XP_008194395.1 1811 2.8e-199 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 612 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1236 5.4e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF12052//PF08437//PF00018//PF01424 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal//SH3 domain//R3H domain GO:0009103//GO:0006816//GO:0070588 lipopolysaccharide biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0005515//GO:0003676//GO:0005245//GO:0008918 protein binding//nucleic acid binding//voltage-gated calcium channel activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.44718 BF_2 96.46 2.93 1665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44719 BF_2 65.55 0.55 5287 642924682 XP_008194395.1 1870 5.0e-206 PREDICTED: voltage-dependent L-type calcium channel subunit beta-2 isoform X4 [Tribolium castaneum] 642924681 XM_008196173.1 637 0 PREDICTED: Tribolium castaneum voltage-dependent L-type calcium channel subunit beta-2 (LOC663831), transcript variant X4, mRNA K04863 CACNB2 voltage-dependent calcium channel beta-2 http://www.genome.jp/dbget-bin/www_bget?ko:K04863 P54288 1236 6.7e-134 Voltage-dependent L-type calcium channel subunit beta-2 OS=Oryctolagus cuniculus GN=CACNB2 PE=1 SV=1 PF12052//PF08437//PF01424//PF00018 Voltage gated calcium channel subunit beta domain 4Aa N terminal//Glycosyl transferase family 8 C-terminal//R3H domain//SH3 domain GO:0009103//GO:0006816//GO:0070588 lipopolysaccharide biosynthetic process//calcium ion transport//calcium ion transmembrane transport GO:0003676//GO:0005245//GO:0008918//GO:0005515 nucleic acid binding//voltage-gated calcium channel activity//lipopolysaccharide 3-alpha-galactosyltransferase activity//protein binding GO:0005891 voltage-gated calcium channel complex KOG3812 L-type voltage-dependent Ca2+ channel, beta subunit Cluster-8309.44721 BF_2 610.49 17.03 1787 646723939 KDR24373.1 1858 4.1e-205 T-complex protein 1 subunit gamma [Zootermopsis nevadensis] 124487747 EF091969.1 234 6.68131e-117 Maconellicoccus hirsutus clone WHMH3794 putative T-complex protein 1 subunit gamma mRNA, partial cds K09495 CCT3, TRIC5 T-complex protein 1 subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K09495 P48605 1813 2.8e-201 T-complex protein 1 subunit gamma OS=Drosophila melanogaster GN=Cctgamma PE=2 SV=2 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding -- -- KOG0364 Chaperonin complex component, TCP-1 gamma subunit (CCT3) Cluster-8309.44726 BF_2 58.68 2.66 1210 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44730 BF_2 11.00 11.94 314 123439425 XP_001310484.1 185 7.2e-12 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121892256|gb|EAX97554.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q9STP8 161 1.8e-10 Acyl-CoA-binding domain-containing protein 2 OS=Arabidopsis thaliana GN=ACBP2 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44734 BF_2 902.07 12.91 3210 478256479 ENN76664.1 1569 2.4e-171 hypothetical protein YQE_06843, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q869E1 144 1.7e-07 DNA ligase 1 OS=Dictyostelium discoideum GN=lig1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44737 BF_2 3192.14 38.61 3746 270017242 EFA13688.1 1493 1.8e-162 hypothetical protein TcasGA2_TC001594 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 1.1e-111 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF05118//PF02737//PF00515//PF04812//PF13414//PF13176//PF13181//PF13174 Aspartyl/Asparaginyl beta-hydroxylase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Tetratricopeptide repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0055114//GO:0006554//GO:0006552//GO:0045893//GO:0018193//GO:0006631//GO:0006568//GO:0006633//GO:0018874//GO:0006574//GO:0006550 oxidation-reduction process//lysine catabolic process//leucine catabolic process//positive regulation of transcription, DNA-templated//peptidyl-amino acid modification//fatty acid metabolic process//tryptophan metabolic process//fatty acid biosynthetic process//benzoate metabolic process//valine catabolic process//isoleucine catabolic process GO:0003857//GO:0016491//GO:0005515 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//protein binding GO:0005634 nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.44738 BF_2 60.88 0.68 4041 546672114 ERL84135.1 1143 7.6e-122 hypothetical protein D910_01486 [Dendroctonus ponderosae]>gi|546675290|gb|ERL86521.1| hypothetical protein D910_03927 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NAG6 531 2.9e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.44739 BF_2 117.45 1.11 4723 270015509 EFA11957.1 1503 1.6e-163 serine protease H82 [Tribolium castaneum] 641658676 XM_001951259.3 168 8.73543e-80 PREDICTED: Acyrthosiphon pisum hornerin (LOC100164097), transcript variant X2, mRNA -- -- -- -- Q96EN8 486 5.6e-47 Molybdenum cofactor sulfurase OS=Homo sapiens GN=MOCOS PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.44740 BF_2 1155.67 20.04 2699 642916167 XP_008190914.1 1078 1.7e-114 PREDICTED: uncharacterized protein LOC103312328 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44743 BF_2 8.98 0.43 1168 270004596 EFA01044.1 1106 4.3e-118 hypothetical protein TcasGA2_TC003960 [Tribolium castaneum] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q8C8R3 553 2.3e-55 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4177 Ankyrin Cluster-8309.44745 BF_2 902.05 16.56 2566 642929001 XP_008195650.1 2028 1.2e-224 PREDICTED: thrombospondin type-1 domain-containing protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UY14 845 7.1e-89 ADAMTS-like protein 4 OS=Homo sapiens GN=ADAMTSL4 PE=1 SV=2 PF05986//PF08686 ADAM-TS Spacer 1//PLAC (protease and lacunin) domain -- -- GO:0008233//GO:0004222 peptidase activity//metalloendopeptidase activity GO:0031012 extracellular matrix KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.44750 BF_2 51.88 0.44 5233 270004497 EFA00945.1 2146 4.9e-238 hypothetical protein TcasGA2_TC003854 [Tribolium castaneum] -- -- -- -- -- K14416 HBS1 elongation factor 1 alpha-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K14416 Q69ZS7 1399 8.4e-153 HBS1-like protein OS=Mus musculus GN=Hbs1l PE=1 SV=2 PF03144//PF05773//PF01926//PF09445 Elongation factor Tu domain 2//RWD domain//50S ribosome-binding GTPase//RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0005525//GO:0008168//GO:0005515 GTP binding//methyltransferase activity//protein binding -- -- KOG0458 Elongation factor 1 alpha Cluster-8309.44753 BF_2 266.81 4.48 2777 642934573 XP_008197722.1 2027 1.6e-224 PREDICTED: uncharacterized protein LOC658962 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10314 FBXO39 F-box protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K10314 -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44754 BF_2 1034.17 16.67 2882 478250393 ENN70888.1 2076 3.5e-230 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 751 6.4e-78 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF03404//PF00107 Mo-co oxidoreductase dimerisation domain//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0030151 oxidoreductase activity//molybdenum ion binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.44756 BF_2 208.04 2.38 3951 570341982 AHE77387.1 1798 8.3e-198 heat shock protein 70, partial [Lissorhoptrus oryzophilus] 645000994 XM_001599723.3 244 4.12054e-122 PREDICTED: Nasonia vitripennis heat shock protein 68-like (LOC100114907), mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P41825 1624 5.1e-179 Heat shock protein 70 A1 OS=Anopheles albimanus GN=HSP70A1 PE=3 SV=1 PF00560//PF02782//PF13855 Leucine Rich Repeat//FGGY family of carbohydrate kinases, C-terminal domain//Leucine rich repeat GO:0005975 carbohydrate metabolic process GO:0005515//GO:0016773 protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.4476 BF_2 8.00 0.58 867 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.44763 BF_2 4.14 0.35 783 642925447 XP_008194558.1 385 1.2e-34 PREDICTED: cellular FABP-like protein isoform X2 [Tribolium castaneum] -- -- -- -- -- K08756 FABP7 fatty acid-binding protein 7, brain http://www.genome.jp/dbget-bin/www_bget?ko:K08756 A6YLM6 196 3.9e-14 Fatty acid-binding protein, adipocyte OS=Cervus elaphus GN=FABP4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.44764 BF_2 840.10 4.68 7799 270012248 EFA08696.1 940 5.1e-98 hypothetical protein TcasGA2_TC006367 [Tribolium castaneum] -- -- -- -- -- K14570 REX1, REXO1, RNH70 RNA exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14570 Q8IX06 586 2.3e-58 Putative exonuclease GOR OS=Homo sapiens GN=REXO1L1P PE=5 SV=2 PF02932//PF03930//PF00400//PF00930//PF01612 Neurotransmitter-gated ion-channel transmembrane region//Recombinase Flp protein N-terminus//WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//3'-5' exonuclease GO:0006811//GO:0006508//GO:0006310//GO:0006139 ion transport//proteolysis//DNA recombination//nucleobase-containing compound metabolic process GO:0003676//GO:0008408//GO:0005515 nucleic acid binding//3'-5' exonuclease activity//protein binding GO:0016020 membrane KOG2248 3'-5' exonuclease Cluster-8309.44766 BF_2 75.85 0.96 3587 642933817 XP_008197388.1 674 1.6e-67 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TN34 370 1.2e-33 MICAL-like protein 2 OS=Mus musculus GN=Micall2 PE=1 SV=1 PF00307//PF00288 Calponin homology (CH) domain//GHMP kinases N terminal domain -- -- GO:0005515//GO:0005524 protein binding//ATP binding -- -- -- -- Cluster-8309.44767 BF_2 6.38 0.31 1160 546680705 ERL90931.1 694 2.5e-70 hypothetical protein D910_08274, partial [Dendroctonus ponderosae] -- -- -- -- -- K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 537 1.7e-53 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.44768 BF_2 107.37 2.25 2279 642930218 XP_008196305.1 2314 7.0e-258 PREDICTED: protein UBASH3A homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 1098 2.9e-118 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.44770 BF_2 1306.95 14.50 4057 189241935 XP_969741.2 2165 2.4e-240 PREDICTED: coronin-2B-like isoform X2 [Tribolium castaneum] 612001587 XM_007485717.1 39 3.84971e-08 PREDICTED: Monodelphis domestica coronin 6 (CORO6), transcript variant X3, mRNA K13887 CORO2 coronin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13887 A8WGE3 1310 1.4e-142 Coronin-2B OS=Xenopus tropicalis GN=coro2b PE=2 SV=1 PF00400//PF04977 WD domain, G-beta repeat//Septum formation initiator GO:0007049 cell cycle GO:0005515 protein binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.44771 BF_2 489.28 3.45 6213 478263644 ENN81950.1 1558 8.8e-170 hypothetical protein YQE_01661, partial [Dendroctonus ponderosae]>gi|546676683|gb|ERL87639.1| hypothetical protein D910_05030 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9I7H9 662 2.9e-67 Prolyl 3-hydroxylase sudestada1 OS=Drosophila melanogaster GN=sud1 PE=2 SV=1 PF07527//PF00010//PF03594//PF13640//PF10637 Hairy Orange//Helix-loop-helix DNA-binding domain//Benzoate membrane transport protein//2OG-Fe(II) oxygenase superfamily//Oxoglutarate and iron-dependent oxygenase degradation C-term GO:0006355//GO:0055114//GO:0042919//GO:0006810 regulation of transcription, DNA-templated//oxidation-reduction process//benzoate transport//transport GO:0016706//GO:0031418//GO:0042925//GO:0005506//GO:0003677//GO:0046983//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//L-ascorbic acid binding//benzoate transporter activity//iron ion binding//DNA binding//protein dimerization activity//oxidoreductase activity GO:0016021 integral component of membrane -- -- Cluster-8309.44772 BF_2 1.00 4.80 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44777 BF_2 472.31 4.25 4936 642917920 XP_008200607.1 2695 1.0e-301 PREDICTED: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [Tribolium castaneum] -- -- -- -- -- K00738 MGAT4A_B alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B http://www.genome.jp/dbget-bin/www_bget?ko:K00738 Q6GMK0 1217 1.0e-131 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B OS=Danio rerio GN=mgat4b PE=2 SV=1 PF01991//PF04666 ATP synthase (E/31 kDa) subunit//N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region GO:0015992//GO:0005975//GO:0006119//GO:0015991 proton transport//carbohydrate metabolic process//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0046961//GO:0016758 proton-transporting ATPase activity, rotational mechanism//transferase activity, transferring hexosyl groups GO:0016020//GO:0033178 membrane//proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.44779 BF_2 228.83 1.37 7250 91076138 XP_970159.1 2672 6.9e-299 PREDICTED: catenin alpha [Tribolium castaneum]>gi|642911687|ref|XP_008200701.1| PREDICTED: catenin alpha [Tribolium castaneum]>gi|642911689|ref|XP_008200702.1| PREDICTED: catenin alpha [Tribolium castaneum]>gi|270014573|gb|EFA11021.1| hypothetical protein TcasGA2_TC004609 [Tribolium castaneum] 642911688 XM_008202480.1 594 0 PREDICTED: Tribolium castaneum catenin alpha (LOC658703), transcript variant X3, mRNA K05691 CTNNA catenin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05691 P35220 2281 6.2e-255 Catenin alpha OS=Drosophila melanogaster GN=alpha-Cat PE=1 SV=2 PF08919//PF00328//PF03223//PF00639//PF01044//PF01608//PF00435//PF04632 F-actin binding//Histidine phosphatase superfamily (branch 2)//V-ATPase subunit C//PPIC-type PPIASE domain//Vinculin family//I/LWEQ domain//Spectrin repeat//Fusaric acid resistance protein family GO:0006810//GO:0019497//GO:0006468//GO:0015992//GO:0015991//GO:0006771//GO:0007155 transport//hexachlorocyclohexane metabolic process//protein phosphorylation//proton transport//ATP hydrolysis coupled proton transport//riboflavin metabolic process//cell adhesion GO:0003779//GO:0005198//GO:0045296//GO:0005524//GO:0003993//GO:0051015//GO:0015078//GO:0005515//GO:0016853//GO:0004715 actin binding//structural molecule activity//cadherin binding//ATP binding//acid phosphatase activity//actin filament binding//hydrogen ion transmembrane transporter activity//protein binding//isomerase activity//non-membrane spanning protein tyrosine kinase activity GO:0033180//GO:0015629//GO:0005886 proton-transporting V-type ATPase, V1 domain//actin cytoskeleton//plasma membrane KOG3681 Alpha-catenin Cluster-8309.44782 BF_2 1.00 7.77 240 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44786 BF_2 1150.65 10.29 4965 91084129 XP_969781.1 4516 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|642924905|ref|XP_008194092.1| PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270008023|gb|EFA04471.1| hypothetical protein TcasGA2_TC014775 [Tribolium castaneum] 815905118 XM_012383019.1 51 1.00714e-14 PREDICTED: Bombus impatiens multidrug resistance-associated protein 4-like (LOC100745129), mRNA -- -- -- -- Q54U44 1414 1.4e-154 ABC transporter C family member 12 OS=Dictyostelium discoideum GN=abcC12 PE=3 SV=1 PF03193//PF00005//PF01637//PF02456//PF06552//PF00931//PF08477//PF01926//PF13304//PF00664//PF00437 Protein of unknown function, DUF258//ABC transporter//Archaeal ATPase//Adenovirus IVa2 protein//Plant specific mitochondrial import receptor subunit TOM20//NB-ARC domain//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0055085//GO:0019083//GO:0006810//GO:0045040//GO:0007264//GO:0009987 transmembrane transport//viral transcription//transport//protein import into mitochondrial outer membrane//small GTPase mediated signal transduction//cellular process GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0000166//GO:0016887//GO:0042626 ATP binding//ADP binding//GTPase activity//GTP binding//nucleotide binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0005742 integral component of membrane//mitochondrial outer membrane translocase complex -- -- Cluster-8309.44789 BF_2 95.27 1.29 3381 478253357 ENN73716.1 926 9.3e-97 hypothetical protein YQE_09686, partial [Dendroctonus ponderosae]>gi|478266907|gb|ENN82945.1| hypothetical protein YQE_00690, partial [Dendroctonus ponderosae]>gi|546681927|gb|ERL91923.1| hypothetical protein D910_09246 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2ABP2 551 1.2e-54 Post-GPI attachment to proteins factor 2 OS=Cricetulus griseus GN=Pgap2 PE=2 SV=1 PF01848 Hok/gef family -- -- -- -- GO:0016020 membrane KOG3979 FGF receptor activating protein 1 Cluster-8309.44790 BF_2 12.68 0.58 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44791 BF_2 1271.86 12.45 4561 642911425 XP_008199417.1 1790 8.1e-197 PREDICTED: uncharacterized protein LOC103314658 [Tribolium castaneum]>gi|270014802|gb|EFA11250.1| hypothetical protein TcasGA2_TC010783 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62675 357 4.9e-32 Pro-interleukin-16 OS=Macaca mulatta GN=IL16 PE=2 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.44796 BF_2 7.00 0.34 1156 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44798 BF_2 987.79 6.19 6965 642917278 XP_008199232.1 1608 1.6e-175 PREDICTED: carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein isoform X2 [Tribolium castaneum] 685047512 LN596024.1 38 2.38486e-07 Cyprinus carpio genome assembly common carp genome ,scaffold 000002447 K16513 NOS1AP, CAPON carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein http://www.genome.jp/dbget-bin/www_bget?ko:K16513 O54960 737 6.5e-76 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Rattus norvegicus GN=Nos1ap PE=1 SV=1 PF00640 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4815 Muscular protein implicated in muscular dystrophy phenotype Cluster-8309.44799 BF_2 109.95 2.44 2174 91077688 XP_974709.1 1738 4.1e-191 PREDICTED: protein PTCD3 homolog, mitochondrial [Tribolium castaneum]>gi|270001531|gb|EEZ97978.1| hypothetical protein TcasGA2_TC000373 [Tribolium castaneum] -- -- -- -- -- K17659 PTCD3 pentatricopeptide repeat domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17659 A1Z9A8 1410 1.8e-154 Protein PTCD3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4679 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.448 BF_2 2.00 2.34 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44800 BF_2 630.05 14.37 2121 91077688 XP_974709.1 2028 9.5e-225 PREDICTED: protein PTCD3 homolog, mitochondrial [Tribolium castaneum]>gi|270001531|gb|EEZ97978.1| hypothetical protein TcasGA2_TC000373 [Tribolium castaneum] -- -- -- -- -- K17659 PTCD3 pentatricopeptide repeat domain-containing protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17659 A1Z9A8 1606 3.4e-177 Protein PTCD3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG4679 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44801 BF_2 52.54 0.49 4796 270009357 EFA05805.1 2692 2.2e-301 hypothetical protein TcasGA2_TC030720 [Tribolium castaneum] -- -- -- -- -- K10875 RAD54L, RAD54 DNA repair and recombination protein RAD54 and RAD54-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K10875 B4MX21 1952 5.8e-217 DNA repair and recombination protein RAD54-like OS=Drosophila willistoni GN=okr PE=3 SV=1 PF08658//PF00270//PF04851//PF01484//PF00176 Rad54 N terminal//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//Nematode cuticle collagen N-terminal domain//SNF2 family N-terminal domain -- -- GO:0005524//GO:0016787//GO:0003677//GO:0003676//GO:0042302//GO:0016817 ATP binding//hydrolase activity//DNA binding//nucleic acid binding//structural constituent of cuticle//hydrolase activity, acting on acid anhydrides -- -- KOG0390 DNA repair protein, SNF2 family Cluster-8309.44803 BF_2 547.25 2.56 9227 91083997 XP_975257.1 1901 2.2e-209 PREDICTED: phosphatidate cytidylyltransferase, photoreceptor-specific [Tribolium castaneum]>gi|270007993|gb|EFA04441.1| hypothetical protein TcasGA2_TC014743 [Tribolium castaneum] 729297249 XM_010548190.1 40 2.44555e-08 PREDICTED: Tarenaya hassleriana phosphatidate cytidylyltransferase (LOC104818548), transcript variant X5, mRNA K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 1615 1.3e-177 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 PF12861//PF12906//PF12678//PF05485//PF14604//PF00018//PF13639 Anaphase-promoting complex subunit 11 RING-H2 finger//RING-variant domain//RING-H2 zinc finger//THAP domain//Variant SH3 domain//SH3 domain//Ring finger domain GO:0016024//GO:0046486//GO:0008654//GO:0016567 CDP-diacylglycerol biosynthetic process//glycerolipid metabolic process//phospholipid biosynthetic process//protein ubiquitination GO:0003676//GO:0008270//GO:0004605//GO:0005515//GO:0004842 nucleic acid binding//zinc ion binding//phosphatidate cytidylyltransferase activity//protein binding//ubiquitin-protein transferase activity GO:0016021//GO:0005680 integral component of membrane//anaphase-promoting complex KOG1440 CDP-diacylglycerol synthase Cluster-8309.44806 BF_2 437.00 8.11 2542 642924866 XP_008194074.1 942 9.7e-99 PREDICTED: protein crossbronx homolog [Tribolium castaneum] 665792379 XM_008545569.1 54 1.10136e-16 PREDICTED: Microplitis demolitor UPF0598 protein CG30010 (LOC103568629), transcript variant X3, mRNA -- -- -- -- Q7K4V4 498 1.2e-48 Protein crossbronx OS=Drosophila melanogaster GN=cbx PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.44807 BF_2 163.85 1.65 4438 332375999 AEE63140.1 1341 9.2e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DGR4 833 3.0e-87 Protein HGH1 homolog OS=Danio rerio GN=hgh1 PE=2 SV=1 PF05485//PF00096 THAP domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- KOG2973 Uncharacterized conserved protein Cluster-8309.44809 BF_2 19.00 0.77 1323 642913828 XP_008201177.1 790 2.1e-81 PREDICTED: microtubule-associated protein tau isoform X3 [Tribolium castaneum] -- -- -- -- -- K04380 MAPT, TAU microtubule-associated protein tau http://www.genome.jp/dbget-bin/www_bget?ko:K04380 P15146 310 4.0e-27 Microtubule-associated protein 2 OS=Rattus norvegicus GN=Map2 PE=1 SV=3 PF00418 Tau and MAP protein, tubulin-binding repeat -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex KOG2418 Microtubule-associated protein TAU Cluster-8309.44810 BF_2 2967.91 33.07 4041 91092998 XP_968397.1 1000 2.9e-105 PREDICTED: ras-related protein Rac1 [Tribolium castaneum]>gi|270004802|gb|EFA01250.1| Ras-related protein Rac1 [Tribolium castaneum] 751452676 XM_011182416.1 179 5.72962e-86 PREDICTED: Bactrocera cucurbitae ras-related protein Rac1 (LOC105211120), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 P40792 956 1.5e-101 Ras-related protein Rac1 OS=Drosophila melanogaster GN=Rac1 PE=1 SV=2 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding GO:0005622//GO:0016020 intracellular//membrane KOG0393 Ras-related small GTPase, Rho type Cluster-8309.44812 BF_2 11.84 0.31 1884 332374412 AEE62347.1 607 5.0e-60 unknown [Dendroctonus ponderosae]>gi|478255244|gb|ENN75473.1| hypothetical protein YQE_08022, partial [Dendroctonus ponderosae]>gi|546671879|gb|ERL83998.1| hypothetical protein D910_01314 [Dendroctonus ponderosae]>gi|546679662|gb|ERL90089.1| hypothetical protein D910_07443 [Dendroctonus ponderosae] -- -- -- -- -- K13347 PXMP2, PMP22 peroxisomal membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13347 Q9ZS51 170 9.7e-11 Peroxisomal membrane protein PMP22 OS=Arabidopsis thaliana GN=PMP22 PE=1 SV=1 PF06027//PF04117 Solute carrier family 35//Mpv17 / PMP22 family GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.44813 BF_2 29.80 0.32 4137 546674815 ERL86101.1 1860 5.6e-205 hypothetical protein D910_03515 [Dendroctonus ponderosae] 815800151 XM_012365304.1 53 6.47779e-16 PREDICTED: Linepithema humile uncharacterized LOC105671296 (LOC105671296), transcript variant X3, mRNA -- -- -- -- B0UYT5 156 9.0e-09 Major facilitator superfamily domain-containing protein 6-B OS=Danio rerio GN=mfsd6b PE=3 SV=1 PF01306//PF07690 LacY proton/sugar symporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.44814 BF_2 21.98 0.65 1698 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06374 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) GO:0015992//GO:0006814//GO:0006120//GO:0006744 proton transport//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.44815 BF_2 22.25 1.09 1142 478255595 ENN75809.1 691 5.5e-70 hypothetical protein YQE_07645, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.44816 BF_2 940.67 72.89 827 332374374 AEE62328.1 687 1.2e-69 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44817 BF_2 94.20 1.38 3144 91089355 XP_972978.1 757 3.4e-77 PREDICTED: innexin inx2 [Tribolium castaneum]>gi|270011438|gb|EFA07886.1| hypothetical protein TcasGA2_TC005460 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XYN1 619 1.4e-62 Innexin inx2 OS=Schistocerca americana GN=inx2 PE=1 SV=1 PF00876//PF08587 Innexin//Ubiquitin associated domain (UBA) GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0004674 protein serine/threonine kinase activity GO:0005921 gap junction -- -- Cluster-8309.44818 BF_2 731.68 17.68 2018 91088421 XP_967011.1 289 4.0e-23 PREDICTED: activated RNA polymerase II transcriptional coactivator p15 [Tribolium castaneum]>gi|270012200|gb|EFA08648.1| hypothetical protein TcasGA2_TC006312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11031 175 2.7e-11 Activated RNA polymerase II transcriptional coactivator p15 OS=Mus musculus GN=Sub1 PE=1 SV=3 PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003713//GO:0003677 transcription coactivator activity//DNA binding GO:0005667 transcription factor complex KOG2712 Transcriptional coactivator Cluster-8309.44820 BF_2 462.94 2.42 8304 170042086 XP_001848770.1 1358 1.8e-146 RING finger protein 121 [Culex quinquefasciatus]>gi|167865628|gb|EDS29011.1| RING finger protein 121 [Culex quinquefasciatus] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 1112 2.5e-119 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 PF02687//PF00097//PF14634//PF17123//PF12678//PF13639//PF12861//PF09773 FtsX-like permease family//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger//RING-H2 zinc finger//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Meckelin (Transmembrane protein 67) GO:0010826//GO:0042384//GO:0016567 negative regulation of centrosome duplication//cilium assembly//protein ubiquitination GO:0046872//GO:0008270//GO:0004842//GO:0005515 metal ion binding//zinc ion binding//ubiquitin-protein transferase activity//protein binding GO:0036038//GO:0016020//GO:0005680 TCTN-B9D complex//membrane//anaphase-promoting complex KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.44822 BF_2 844.00 8.55 4415 91089371 XP_973545.1 3861 0.0e+00 PREDICTED: calcium-activated chloride channel regulator 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54281 456 1.6e-43 Epithelial chloride channel protein OS=Bos taurus PE=2 SV=1 PF02480//PF10462 Alphaherpesvirus glycoprotein E//Peptidase M66 -- -- GO:0004222 metalloendopeptidase activity GO:0016020 membrane -- -- Cluster-8309.44824 BF_2 12.83 0.38 1690 282403501 NP_001164148.1 896 1.4e-93 fumble isoform 3 [Tribolium castaneum]>gi|270002881|gb|EEZ99328.1| fumble [Tribolium castaneum] 746854770 XM_011059724.1 63 7.21941e-22 PREDICTED: Acromyrmex echinatior pantothenate kinase 3 (LOC105148170), transcript variant X9, mRNA K09680 coaW type II pantothenate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09680 Q9BZ23 611 6.4e-62 Pantothenate kinase 2, mitochondrial OS=Homo sapiens GN=PANK2 PE=1 SV=3 PF03630 Fumble GO:0015937//GO:0015940 coenzyme A biosynthetic process//pantothenate biosynthetic process GO:0004594//GO:0005524 pantothenate kinase activity//ATP binding -- -- KOG2201 Pantothenate kinase PanK and related proteins Cluster-8309.44825 BF_2 393.37 2.69 6406 642938167 XP_008190994.1 878 6.5e-91 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NQ0 408 8.4e-38 G-protein coupled receptor Mth2 OS=Drosophila simulans GN=mth2 PE=3 SV=1 PF00002//PF00001//PF04644 7 transmembrane receptor (Secretin family)//7 transmembrane receptor (rhodopsin family)//Motilin/ghrelin GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0005179//GO:0004930 hormone activity//G-protein coupled receptor activity GO:0005576//GO:0016021 extracellular region//integral component of membrane -- -- Cluster-8309.44826 BF_2 378.42 12.47 1557 478252036 ENN72467.1 917 4.7e-96 hypothetical protein YQE_10809, partial [Dendroctonus ponderosae] 586460488 XM_006860838.1 137 4.85004e-63 PREDICTED: Chrysochloris asiatica NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (NDUFS8), mRNA K03941 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K03941 P42028 772 1.3e-80 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Bos taurus GN=NDUFS8 PE=1 SV=1 PF05130//PF01297//PF08782//PF05187 FlgN protein//Zinc-uptake complex component A periplasmic//c-SKI Smad4 binding domain//Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GO:0044780//GO:0030001//GO:0055114 bacterial-type flagellum assembly//metal ion transport//oxidation-reduction process GO:0004174//GO:0046332//GO:0046872 electron-transferring-flavoprotein dehydrogenase activity//SMAD binding//metal ion binding -- -- KOG3256 NADH:ubiquinone oxidoreductase, NDUFS8/23 kDa subunit Cluster-8309.44827 BF_2 844.00 20.32 2025 478266386 ENN82777.1 1064 5.5e-113 hypothetical protein YQE_00855, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 336 5.9e-30 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.44828 BF_2 34.42 0.61 2646 642935358 XP_008197980.1 1191 1.4e-127 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44831 BF_2 219.76 1.06 8959 642916561 XP_008191701.1 2302 6.8e-256 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] 642916712 XM_001813000.2 329 5.26391e-169 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q5T2T1 1155 2.8e-124 MAGUK p55 subfamily member 7 OS=Homo sapiens GN=MPP7 PE=1 SV=1 PF00651//PF14604//PF00018//PF00595//PF05225//PF13180 BTB/POZ domain//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF)//helix-turn-helix, Psq domain//PDZ domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.44833 BF_2 9.00 0.44 1138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44834 BF_2 2258.66 25.50 3993 91082721 XP_972476.1 730 5.8e-74 PREDICTED: uncharacterized protein LOC661208 [Tribolium castaneum]>gi|270014957|gb|EFA11405.1| hypothetical protein TcasGA2_TC013579 [Tribolium castaneum] -- -- -- -- -- K16678 EGR eiger http://www.genome.jp/dbget-bin/www_bget?ko:K16678 -- -- -- -- PF00229 TNF(Tumour Necrosis Factor) family GO:0006955//GO:0007165 immune response//signal transduction GO:0005164 tumor necrosis factor receptor binding GO:0016020 membrane -- -- Cluster-8309.44836 BF_2 3.00 0.32 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44838 BF_2 893.92 4.41 8773 546685536 ERL95023.1 3214 0.0e+00 hypothetical protein D910_12293 [Dendroctonus ponderosae] 780637936 XM_011688946.1 186 1.6048e-89 PREDICTED: Wasmannia auropunctata LIM domain kinase 1 (LOC105449641), transcript variant X2, mRNA K05743 LIMK1 LIM domain kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05743 Q8IR79 1694 8.7e-187 LIM domain kinase 1 OS=Drosophila melanogaster GN=LIMK1 PE=1 SV=1 PF10392//PF05929//PF00595//PF05478//PF07851//PF05531//PF06009//PF16331//PF02601//PF04513//PF04728//PF01621//PF00412//PF16740//PF00170//PF04871//PF00069//PF07714//PF07544//PF08289//PF06293//PF10473//PF06160 Golgi transport complex subunit 5//Phage capsid scaffolding protein (GPO) serine peptidase//PDZ domain (Also known as DHR or GLGF)//Prominin//TMPIT-like protein//Nucleopolyhedrovirus P10 protein//Laminin Domain II//TolA binding protein trimerisation//Exonuclease VII, large subunit//Baculovirus polyhedron envelope protein, PEP, C terminus//Lipoprotein leucine-zipper//Cell fusion glycoprotein K//LIM domain//Spindle and kinetochore-associated protein 2//bZIP transcription factor//Uso1 / p115 like vesicle tethering protein, C terminal region//Protein kinase domain//Protein tyrosine kinase//RNA polymerase II transcription mediator complex subunit 9//Influenza Matrix protein (M1) C-terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Septation ring formation regulator, EzrA GO:0006891//GO:0000921//GO:0051301//GO:0006357//GO:0007155//GO:0019069//GO:0006308//GO:0031110//GO:0000090//GO:0006355//GO:0007067//GO:0007059//GO:0015031//GO:0006886//GO:0070206//GO:0006468 intra-Golgi vesicle-mediated transport//septin ring assembly//cell division//regulation of transcription from RNA polymerase II promoter//cell adhesion//viral capsid assembly//DNA catabolic process//regulation of microtubule polymerization or depolymerization//mitotic anaphase//regulation of transcription, DNA-templated//mitotic nuclear division//chromosome segregation//protein transport//intracellular protein transport//protein trimerization//protein phosphorylation GO:0016773//GO:0004672//GO:0001104//GO:0003700//GO:0005524//GO:0008134//GO:0045502//GO:0008017//GO:0042803//GO:0003723//GO:0005515//GO:0008855//GO:0008565//GO:0043565//GO:0008270//GO:0005198 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//RNA polymerase II transcription cofactor activity//transcription factor activity, sequence-specific DNA binding//ATP binding//transcription factor binding//dynein binding//microtubule binding//protein homodimerization activity//RNA binding//protein binding//exodeoxyribonuclease VII activity//protein transporter activity//sequence-specific DNA binding//zinc ion binding//structural molecule activity GO:0030286//GO:0016592//GO:0005667//GO:0009318//GO:0019028//GO:0045298//GO:0017119//GO:0000940//GO:0016020//GO:0019867//GO:0019031//GO:0005876//GO:0005737//GO:0016021//GO:0005940 dynein complex//mediator complex//transcription factor complex//exodeoxyribonuclease VII complex//viral capsid//tubulin complex//Golgi transport complex//condensed chromosome outer kinetochore//membrane//outer membrane//viral envelope//spindle microtubule//cytoplasm//integral component of membrane//septin ring -- -- Cluster-8309.44840 BF_2 585.87 4.05 6335 642919657 XP_008192010.1 2446 9.7e-273 PREDICTED: kinesin light chain isoform X2 [Tribolium castaneum]>gi|270005876|gb|EFA02324.1| hypothetical protein TcasGA2_TC007992 [Tribolium castaneum] 817205684 XM_012423337.1 328 1.33643e-168 PREDICTED: Orussus abietinus kinesin light chain (LOC105698786), transcript variant X2, mRNA K10407 KLC kinesin light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10407 P46824 1708 1.5e-188 Kinesin light chain OS=Drosophila melanogaster GN=Klc PE=1 SV=1 PF13181//PF06156//PF13174//PF03836//PF13374//PF00515//PF00637//PF13414//PF11365//PF13176 Tetratricopeptide repeat//Protein of unknown function (DUF972)//Tetratricopeptide repeat//RasGAP C-terminus//Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//TPR repeat//Protein of unknown function (DUF3166)//Tetratricopeptide repeat GO:0010506//GO:0016192//GO:0006886//GO:0007017//GO:0006260//GO:0007264 regulation of autophagy//vesicle-mediated transport//intracellular protein transport//microtubule-based process//DNA replication//small GTPase mediated signal transduction GO:0005096//GO:0005515//GO:0003777 GTPase activator activity//protein binding//microtubule motor activity GO:0005874//GO:0005871//GO:0005615 microtubule//kinesin complex//extracellular space KOG1840 Kinesin light chain Cluster-8309.44842 BF_2 7.00 0.51 866 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44843 BF_2 1008.09 15.24 3055 91076598 XP_968579.1 3213 0.0e+00 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 5.95432e-40 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q93050 2180 1.3e-243 V-type proton ATPase 116 kDa subunit a isoform 1 OS=Homo sapiens GN=ATP6V0A1 PE=1 SV=3 PF01496 V-type ATPase 116kDa subunit family GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.44844 BF_2 23.80 0.44 2530 91076598 XP_968579.1 1385 4.1e-150 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum]>gi|642912657|ref|XP_008200952.1| PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 [Tribolium castaneum] 442619807 NM_169810.2 96 4.92239e-40 Drosophila melanogaster vacuolar H[+] ATPase 100kD subunit 2 (Vha100-2), transcript variant A, mRNA K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q9HBG4 935 2.6e-99 V-type proton ATPase 116 kDa subunit a isoform 4 OS=Homo sapiens GN=ATP6V0A4 PE=1 SV=2 PF02060//PF01496 Slow voltage-gated potassium channel//V-type ATPase 116kDa subunit family GO:0006811//GO:0015992//GO:0015991//GO:0006813 ion transport//proton transport//ATP hydrolysis coupled proton transport//potassium ion transport GO:0015078//GO:0005249 hydrogen ion transmembrane transporter activity//voltage-gated potassium channel activity GO:0016020//GO:0008076//GO:0033179 membrane//voltage-gated potassium channel complex//proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.44845 BF_2 177.64 1.90 4195 340723622 XP_003400188.1 3281 0.0e+00 PREDICTED: protein brunelleschi isoform X1 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q6PA97 1584 2.4e-174 Trafficking protein particle complex subunit 9 OS=Xenopus laevis GN=trappc9 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1953 Targeting complex (TRAPP) subunit Cluster-8309.44846 BF_2 129.65 1.34 4321 340723622 XP_003400188.1 3201 0.0e+00 PREDICTED: protein brunelleschi isoform X1 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q6PA97 1528 7.6e-168 Trafficking protein particle complex subunit 9 OS=Xenopus laevis GN=trappc9 PE=2 SV=1 PF00515 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1953 Targeting complex (TRAPP) subunit Cluster-8309.44847 BF_2 1187.69 5.05 10127 642938459 XP_008199812.1 3950 0.0e+00 PREDICTED: Niemann-Pick C1 protein isoform X3 [Tribolium castaneum] 657584210 XM_008298026.1 56 3.42453e-17 PREDICTED: Stegastes partitus Niemann-Pick disease, type C1 (npc1), transcript variant X2, mRNA K12385 NPC1 Niemann-Pick C1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K12385 P56941 2256 6.8e-252 Niemann-Pick C1 protein OS=Sus scrofa GN=NPC1 PE=2 SV=1 PF03402//PF07677//PF03176//PF02460 Vomeronasal organ pheromone receptor family, V1R//A-macroglobulin receptor//MMPL family//Patched family GO:0007186//GO:0019236//GO:0007606//GO:0007165 G-protein coupled receptor signaling pathway//response to pheromone//sensory perception of chemical stimulus//signal transduction GO:0008158//GO:0016503 hedgehog receptor activity//pheromone receptor activity GO:0016020//GO:0005576//GO:0016021 membrane//extracellular region//integral component of membrane KOG1933 Cholesterol transport protein (Niemann-Pick C disease protein) Cluster-8309.44848 BF_2 100.46 1.36 3375 270000870 EEZ97317.1 1789 7.9e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.36855e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.5e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.44849 BF_2 457.27 4.35 4687 478259245 ENN79147.1 3115 0.0e+00 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] 260807434 XM_002598468.1 159 8.72987e-75 Branchiostoma floridae hypothetical protein, mRNA K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 2572 7.2e-289 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF00004//PF07728//PF01745//PF08752//PF01695//PF00158//PF01926//PF01057//PF00931//PF02367//PF07724//PF06068//PF05496//PF00910//PF06800//PF07726//PF00005//PF01299//PF01637 ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//Isopentenyl transferase//Coatomer gamma subunit appendage platform subdomain//IstB-like ATP binding protein//Sigma-54 interaction domain//50S ribosome-binding GTPase//Parvovirus non-structural protein NS1//NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//RNA helicase//Sugar transport protein//ATPase family associated with various cellular activities (AAA)//ABC transporter//Lysosome-associated membrane glycoprotein (Lamp)//Archaeal ATPase GO:0002949//GO:0006310//GO:0008643//GO:0019079//GO:0016114//GO:0016192//GO:0006281//GO:0006886//GO:0006355//GO:0006694//GO:0034219//GO:0009058 tRNA threonylcarbamoyladenosine modification//DNA recombination//carbohydrate transport//viral genome replication//terpenoid biosynthetic process//vesicle-mediated transport//DNA repair//intracellular protein transport//regulation of transcription, DNA-templated//steroid biosynthetic process//carbohydrate transmembrane transport//biosynthetic process GO:0003678//GO:0003723//GO:0043531//GO:0005525//GO:0009378//GO:0003724//GO:0005524//GO:0005198//GO:0015144//GO:0008134//GO:0004161//GO:0016887 DNA helicase activity//RNA binding//ADP binding//GTP binding//four-way junction helicase activity//RNA helicase activity//ATP binding//structural molecule activity//carbohydrate transmembrane transporter activity//transcription factor binding//dimethylallyltranstransferase activity//ATPase activity GO:0005657//GO:0005667//GO:0016020//GO:0016021//GO:0009379//GO:0030126 replication fork//transcription factor complex//membrane//integral component of membrane//Holliday junction helicase complex//COPI vesicle coat KOG0741 AAA+-type ATPase Cluster-8309.44850 BF_2 452.76 4.31 4681 478259245 ENN79147.1 3115 0.0e+00 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] 260807434 XM_002598468.1 165 4.02778e-78 Branchiostoma floridae hypothetical protein, mRNA K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 2572 7.2e-289 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF00931//PF02367//PF00004//PF00158//PF01926//PF01057//PF07728//PF01745//PF01695//PF08752//PF00910//PF06800//PF01637//PF07726//PF01299//PF00005//PF07724//PF06068//PF05496 NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain//50S ribosome-binding GTPase//Parvovirus non-structural protein NS1//AAA domain (dynein-related subfamily)//Isopentenyl transferase//IstB-like ATP binding protein//Coatomer gamma subunit appendage platform subdomain//RNA helicase//Sugar transport protein//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//Lysosome-associated membrane glycoprotein (Lamp)//ABC transporter//AAA domain (Cdc48 subfamily)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus GO:0008643//GO:0002949//GO:0006310//GO:0016192//GO:0006281//GO:0006886//GO:0016114//GO:0019079//GO:0034219//GO:0009058//GO:0006694//GO:0006355 carbohydrate transport//tRNA threonylcarbamoyladenosine modification//DNA recombination//vesicle-mediated transport//DNA repair//intracellular protein transport//terpenoid biosynthetic process//viral genome replication//carbohydrate transmembrane transport//biosynthetic process//steroid biosynthetic process//regulation of transcription, DNA-templated GO:0043531//GO:0003678//GO:0003723//GO:0009378//GO:0003724//GO:0005525//GO:0015144//GO:0008134//GO:0005198//GO:0005524//GO:0004161//GO:0016887 ADP binding//DNA helicase activity//RNA binding//four-way junction helicase activity//RNA helicase activity//GTP binding//carbohydrate transmembrane transporter activity//transcription factor binding//structural molecule activity//ATP binding//dimethylallyltranstransferase activity//ATPase activity GO:0005667//GO:0005657//GO:0016020//GO:0016021//GO:0009379//GO:0030126 transcription factor complex//replication fork//membrane//integral component of membrane//Holliday junction helicase complex//COPI vesicle coat KOG0741 AAA+-type ATPase Cluster-8309.44851 BF_2 124.36 4.44 1458 546677198 ERL88080.1 790 2.3e-81 hypothetical protein D910_05469 [Dendroctonus ponderosae] -- -- -- -- -- K15262 BCP1, BCCIP protein BCP1 http://www.genome.jp/dbget-bin/www_bget?ko:K15262 Q9VFR0 496 1.2e-48 Protein BCCIP homolog OS=Drosophila melanogaster GN=CG9286 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3034 Isoamyl acetate-hydrolyzing esterase and related enzymes Cluster-8309.44852 BF_2 137.83 1.65 3783 189240899 XP_972980.2 1488 7.0e-162 PREDICTED: protein numb isoform X1 [Tribolium castaneum] 642934702 XM_967887.3 381 0 PREDICTED: Tribolium castaneum protein numb (LOC661741), transcript variant X1, mRNA K06057 NUMBL numb http://www.genome.jp/dbget-bin/www_bget?ko:K06057 P16554 1106 5.7e-119 Protein numb OS=Drosophila melanogaster GN=numb PE=1 SV=2 PF14719//PF08168//PF00640//PF07353 Phosphotyrosine interaction domain (PTB/PID)//NUC205 domain//Phosphotyrosine interaction domain (PTB/PID)//Uroplakin II GO:0061024 membrane organization GO:0005515 protein binding GO:0030176//GO:0005634 integral component of endoplasmic reticulum membrane//nucleus KOG3537 Adaptor protein NUMB Cluster-8309.44853 BF_2 69.53 0.62 4985 189236066 XP_971573.2 1275 4.6e-137 PREDICTED: protein SMG9 [Tribolium castaneum] -- -- -- -- -- K18735 SMG9 protein SMG9 http://www.genome.jp/dbget-bin/www_bget?ko:K18735 Q05AW9 527 1.0e-51 Protein SMG9 OS=Xenopus laevis GN=smg9 PE=2 SV=1 PF09268//PF00005//PF03193//PF00931//PF00910//PF01445//PF00071//PF01926//PF08477//PF00735//PF10220 Clathrin, heavy-chain linker//ABC transporter//Protein of unknown function, DUF258//NB-ARC domain//RNA helicase//Viral small hydrophobic protein//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Uncharacterized conserved protein (DUF2146) GO:0000184//GO:0006886//GO:0016192//GO:0007264 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//intracellular protein transport//vesicle-mediated transport//small GTPase mediated signal transduction GO:0003723//GO:0005524//GO:0043531//GO:0005198//GO:0003924//GO:0005525//GO:0016887//GO:0003724 RNA binding//ATP binding//ADP binding//structural molecule activity//GTPase activity//GTP binding//ATPase activity//RNA helicase activity GO:0030132//GO:0016020//GO:0030130 clathrin coat of coated pit//membrane//clathrin coat of trans-Golgi network vesicle KOG4181 Uncharacterized conserved protein Cluster-8309.44855 BF_2 95.92 5.58 1006 642937671 XP_008198895.1 179 1.1e-10 PREDICTED: E3 ubiquitin-protein ligase RNF19A-like [Tribolium castaneum]>gi|642937673|ref|XP_008198896.1| PREDICTED: E3 ubiquitin-protein ligase RNF19A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44859 BF_2 201.04 6.81 1522 642929512 XP_975068.2 1084 2.0e-115 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Tribolium castaneum] 727003473 XM_010393578.1 39 1.4241e-08 PREDICTED: Corvus cornix cornix 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 O95861 750 4.4e-78 3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens GN=BPNT1 PE=1 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.44860 BF_2 253.81 0.94 11553 478250013 ENN70519.1 1319 8.5e-142 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 249 4.1e-19 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF01280//PF02388 Ribosomal protein L19e//FemAB family GO:0009252//GO:0006412//GO:0042254 peptidoglycan biosynthetic process//translation//ribosome biogenesis GO:0016755//GO:0003735 transferase activity, transferring amino-acyl groups//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.44861 BF_2 44.05 1.07 2017 642931187 XP_008196474.1 308 2.5e-25 PREDICTED: uncharacterized protein LOC103313868 [Tribolium castaneum]>gi|270012111|gb|EFA08559.1| hypothetical protein TcasGA2_TC006214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44862 BF_2 85.54 0.79 4843 642915277 XP_008190552.1 1610 6.4e-176 PREDICTED: breast cancer type 2 susceptibility protein homolog isoform X1 [Tribolium castaneum]>gi|642915279|ref|XP_008190553.1| PREDICTED: breast cancer type 2 susceptibility protein homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K08775 BRCA2, FANCD1 breast cancer 2 susceptibility protein http://www.genome.jp/dbget-bin/www_bget?ko:K08775 P51587 780 4.6e-81 Breast cancer type 2 susceptibility protein OS=Homo sapiens GN=BRCA2 PE=1 SV=2 PF04057//PF09103 Replication factor-A protein 1, N-terminal domain//BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 GO:0000724//GO:0006260 double-strand break repair via homologous recombination//DNA replication GO:0003677 DNA binding GO:0005634 nucleus KOG4751 DNA recombinational repair protein BRCA2 Cluster-8309.44863 BF_2 1185.75 34.50 1725 189241335 XP_001809545.1 1796 6.2e-198 PREDICTED: innexin inx3 [Tribolium castaneum]>gi|270013143|gb|EFA09591.1| hypothetical protein TcasGA2_TC011709 [Tribolium castaneum] 642936310 XM_001809493.2 422 0 PREDICTED: Tribolium castaneum innexin inx3 (LOC100141896), mRNA -- -- -- -- Q9VAS7 1318 6.8e-144 Innexin inx3 OS=Drosophila melanogaster GN=Inx3 PE=1 SV=1 PF00876//PF01292//PF06662 Innexin//Prokaryotic cytochrome b561//D-glucuronyl C5-epimerase C-terminus GO:0006118//GO:0006024 obsolete electron transport//glycosaminoglycan biosynthetic process GO:0016857//GO:0009055 racemase and epimerase activity, acting on carbohydrates and derivatives//electron carrier activity GO:0005921//GO:0016021 gap junction//integral component of membrane -- -- Cluster-8309.44864 BF_2 906.70 4.78 8214 270013321 EFA09769.1 3434 0.0e+00 hypothetical protein TcasGA2_TC011910 [Tribolium castaneum] -- -- -- -- -- K15283 SLC35E1 solute carrier family 35, member E1 http://www.genome.jp/dbget-bin/www_bget?ko:K15283 Q9VR50 1070 1.9e-114 Solute carrier family 35 member E1 homolog OS=Drosophila melanogaster GN=CG14621 PE=2 SV=1 PF00892//PF09165//PF00595//PF13180 EamA-like transporter family//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0006119//GO:0006118//GO:0055114//GO:0015992 oxidative phosphorylation//obsolete electron transport//oxidation-reduction process//proton transport GO:0008121//GO:0005515 ubiquinol-cytochrome-c reductase activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.44865 BF_2 514.61 2.65 8409 642935563 XP_008198060.1 3533 0.0e+00 PREDICTED: glutamate receptor-interacting protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15283 SLC35E1 solute carrier family 35, member E1 http://www.genome.jp/dbget-bin/www_bget?ko:K15283 Q9VR50 1070 1.9e-114 Solute carrier family 35 member E1 homolog OS=Drosophila melanogaster GN=CG14621 PE=2 SV=1 PF00892//PF09165//PF01783//PF13180//PF08088//PF00595 EamA-like transporter family//Ubiquinol-cytochrome c reductase 8 kDa, N-terminal//Ribosomal L32p protein family//PDZ domain//Conotoxin I-superfamily//PDZ domain (Also known as DHR or GLGF) GO:0006412//GO:0006119//GO:0009405//GO:0015992//GO:0042254//GO:0055114//GO:0006118 translation//oxidative phosphorylation//pathogenesis//proton transport//ribosome biogenesis//oxidation-reduction process//obsolete electron transport GO:0005515//GO:0008121//GO:0003735 protein binding//ubiquinol-cytochrome-c reductase activity//structural constituent of ribosome GO:0016021//GO:0015934//GO:0016020//GO:0005576//GO:0005840 integral component of membrane//large ribosomal subunit//membrane//extracellular region//ribosome KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.44866 BF_2 11.84 0.79 910 270013321 EFA09769.1 454 1.3e-42 hypothetical protein TcasGA2_TC011910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E0R9 158 1.2e-09 Glutamate receptor-interacting protein 2 OS=Xenopus laevis GN=grip2 PE=2 SV=2 PF00595 PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.44867 BF_2 363.00 5.23 3193 642935122 XP_008197897.1 4663 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 694449459 XM_009352104.1 77 2.27136e-29 PREDICTED: Pyrus x bretschneideri uncharacterized LOC103941904 (LOC103941904), partial mRNA -- -- -- -- P10079 354 7.6e-32 Fibropellin-1 OS=Strongylocentrotus purpuratus GN=EGF1 PE=1 SV=2 PF03150//PF00023 Di-haem cytochrome c peroxidase//Ankyrin repeat GO:0055114 oxidation-reduction process GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.44868 BF_2 64.25 0.77 3784 189239803 XP_970743.2 594 3.3e-58 PREDICTED: TRAF-type zinc finger domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01001 Hepatitis C virus non-structural protein NS4b GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0003968//GO:0017111//GO:0004252//GO:0004197 RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//cysteine-type endopeptidase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.44870 BF_2 435.30 1.61 11605 478250013 ENN70519.1 1223 1.2e-130 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 192 1.7e-12 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF02388//PF01280 FemAB family//Ribosomal protein L19e GO:0042254//GO:0009252//GO:0006412 ribosome biogenesis//peptidoglycan biosynthetic process//translation GO:0003735//GO:0016755 structural constituent of ribosome//transferase activity, transferring amino-acyl groups GO:0005840//GO:0005622 ribosome//intracellular KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.44876 BF_2 376.76 5.33 3246 751457144 XP_011183174.1 1662 4.0e-182 PREDICTED: protein will die slowly [Bactrocera cucurbitae] 585715269 XM_006825240.1 164 1.00111e-77 PREDICTED: Saccoglossus kowalevskii protein will die slowly-like (LOC100375790), mRNA K14963 WDR5, SWD3, CPS30 COMPASS component SWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K14963 Q9V3J8 1615 4.7e-178 Protein will die slowly OS=Drosophila melanogaster GN=wds PE=1 SV=1 PF07569//PF00400//PF02944 TUP1-like enhancer of split//WD domain, G-beta repeat//BESS motif GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus KOG0266 WD40 repeat-containing protein Cluster-8309.44878 BF_2 408.43 6.43 2943 642912011 XP_008199059.1 1271 8.0e-137 PREDICTED: rho guanine nucleotide exchange factor 17 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80U35 742 7.2e-77 Rho guanine nucleotide exchange factor 17 OS=Mus musculus GN=Arhgef17 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3522 Predicted guanine nucleotide exchange factor Cluster-8309.44880 BF_2 22.78 0.36 2958 642930848 XP_008196112.1 670 3.9e-67 PREDICTED: putative mediator of RNA polymerase II transcription subunit 26 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44883 BF_2 153.77 17.21 661 478251437 ENN71902.1 203 1.2e-13 hypothetical protein YQE_11439, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44884 BF_2 3324.17 126.55 1386 291170322 ADD82417.1 224 9.5e-16 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.44886 BF_2 756.04 6.40 5228 642928927 XP_008195620.1 2115 1.9e-234 PREDICTED: protein lingerer isoform X2 [Tribolium castaneum] 642928926 XM_008197398.1 263 1.49801e-132 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X3, mRNA -- -- -- -- Q16VD3 512 6.0e-50 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44887 BF_2 8.00 0.45 1035 91080995 XP_975051.1 165 5.0e-09 PREDICTED: calnexin [Tribolium castaneum]>gi|642919970|ref|XP_008192150.1| PREDICTED: calnexin [Tribolium castaneum]>gi|642919972|ref|XP_008192151.1| PREDICTED: calnexin [Tribolium castaneum]>gi|270005348|gb|EFA01796.1| hypothetical protein TcasGA2_TC007397 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44890 BF_2 194.44 19.33 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44891 BF_2 711.44 9.32 3481 478250947 ENN71431.1 310 2.6e-25 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P22897 277 7.1e-23 Macrophage mannose receptor 1 OS=Homo sapiens GN=MRC1 PE=1 SV=1 PF03791 KNOX2 domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.44893 BF_2 426.23 3.10 6046 642917633 XP_008193409.1 5050 0.0e+00 PREDICTED: DNA topoisomerase 2 [Tribolium castaneum] 158299571 XM_319665.4 602 0 Anopheles gambiae str. PEST AGAP008917-PA (AgaP_AGAP008917) mRNA, partial cds K03164 TOP2 DNA topoisomerase II http://www.genome.jp/dbget-bin/www_bget?ko:K03164 O16140 4530 0.0e+00 DNA topoisomerase 2 OS=Bombyx mori GN=TOP2 PE=2 SV=1 PF01728//PF00204//PF00521 FtsJ-like methyltransferase//DNA gyrase B//DNA gyrase/topoisomerase IV, subunit A GO:0006265//GO:0032259 DNA topological change//methylation GO:0003677//GO:0003918//GO:0005524//GO:0008168 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding//methyltransferase activity -- -- KOG0355 DNA topoisomerase type II Cluster-8309.44894 BF_2 180.63 0.98 7976 642911937 XP_008199029.1 3528 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 585 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1858 7.6e-206 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF08397//PF07043//PF00885//PF03114//PF00023//PF14604//PF00018//PF00465//PF01412//PF13606 IRSp53/MIM homology domain//Protein of unknown function (DUF1328)//6,7-dimethyl-8-ribityllumazine synthase//BAR domain//Ankyrin repeat//Variant SH3 domain//SH3 domain//Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf//Ankyrin repeat GO:0009231//GO:0055114//GO:0007009 riboflavin biosynthetic process//oxidation-reduction process//plasma membrane organization GO:0016491//GO:0005515//GO:0005096//GO:0046872 oxidoreductase activity//protein binding//GTPase activator activity//metal ion binding GO:0005886//GO:0005737//GO:0009349 plasma membrane//cytoplasm//riboflavin synthase complex KOG3857 Alcohol dehydrogenase, class IV Cluster-8309.44897 BF_2 82.29 0.85 4326 189241229 XP_971878.2 693 1.2e-69 PREDICTED: DNA primase large subunit [Tribolium castaneum]>gi|270013987|gb|EFA10435.1| hypothetical protein TcasGA2_TC012678 [Tribolium castaneum] -- -- -- -- -- K02685 PRI2 DNA primase large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02685 P33610 577 1.4e-57 DNA primase large subunit OS=Mus musculus GN=Prim2 PE=1 SV=1 PF04104 Eukaryotic and archaeal DNA primase, large subunit GO:0006351//GO:0006269 transcription, DNA-templated//DNA replication, synthesis of RNA primer GO:0003896 DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork KOG2267 Eukaryotic-type DNA primase, large subunit Cluster-8309.449 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4490 BF_2 2.00 0.87 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44902 BF_2 9.52 27.46 271 478263705 ENN82008.1 402 4.3e-37 hypothetical protein YQE_01583, partial [Dendroctonus ponderosae]>gi|546671061|gb|ERL83543.1| hypothetical protein D910_00614 [Dendroctonus ponderosae]>gi|546672515|gb|ERL84344.1| hypothetical protein D910_01766 [Dendroctonus ponderosae] -- -- -- -- -- K06114 SPTA spectrin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06114 P13395 350 1.9e-32 Spectrin alpha chain OS=Drosophila melanogaster GN=alpha-Spec PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.44903 BF_2 791.63 11.23 3235 332373230 AEE61756.1 981 3.7e-103 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NAM7 628 1.3e-63 Phytanoyl-CoA dioxygenase domain-containing protein 1 homolog OS=Caenorhabditis elegans GN=Y105C5B.9 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3290 Peroxisomal phytanoyl-CoA hydroxylase Cluster-8309.44904 BF_2 307.12 10.13 1556 546682240 ERL92201.1 2301 1.5e-256 hypothetical protein D910_09521 [Dendroctonus ponderosae] -- -- -- -- -- K15105 SLC25A12_13, AGC solute carrier family 25 (mitochondrial aspartate/glutamate transporter), member 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K15105 Q9VA73 1884 1.4e-209 Calcium-binding mitochondrial carrier protein Aralar1 OS=Drosophila melanogaster GN=aralar1 PE=2 SV=1 PF13405//PF13833//PF00036//PF13499//PF13202 EF-hand domain//EF-hand domain pair//EF hand//EF-hand domain pair//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.44905 BF_2 154.80 0.77 8673 478262704 ENN81251.1 2158 3.3e-239 hypothetical protein YQE_02345, partial [Dendroctonus ponderosae]>gi|546679053|gb|ERL89576.1| hypothetical protein D910_06941 [Dendroctonus ponderosae] 759080227 XM_011351649.1 232 4.25757e-115 PREDICTED: Cerapachys biroi uncharacterized LOC105286595 (LOC105286595), transcript variant X5, mRNA K00889 PIP5K 1-phosphatidylinositol-4-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00889 P70182 1209 1.5e-130 Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha OS=Mus musculus GN=Pip5k1a PE=1 SV=2 PF01504 Phosphatidylinositol-4-phosphate 5-Kinase GO:0046488 phosphatidylinositol metabolic process GO:0016307 phosphatidylinositol phosphate kinase activity -- -- KOG0229 Phosphatidylinositol-4-phosphate 5-kinase Cluster-8309.44908 BF_2 17.32 0.32 2572 642933004 XP_008197224.1 767 1.9e-78 PREDICTED: uncharacterized protein LOC658601 [Tribolium castaneum]>gi|270011458|gb|EFA07906.1| hypothetical protein TcasGA2_TC005481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858//PF04610 Amiloride-sensitive sodium channel//TrbL/VirB6 plasmid conjugal transfer protein GO:0030255//GO:0006814//GO:0006810 protein secretion by the type IV secretion system//sodium ion transport//transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.44909 BF_2 28.49 1.30 1202 642920389 XP_008192326.1 233 7.5e-17 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44910 BF_2 13.00 1.68 610 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44911 BF_2 448.00 13.24 1703 91081999 XP_969259.1 1356 6.4e-147 PREDICTED: ribonucleoside-diphosphate reductase subunit M2 B [Tribolium castaneum]>gi|270007377|gb|EFA03825.1| hypothetical protein TcasGA2_TC013940 [Tribolium castaneum] -- -- -- -- -- K10808 RRM2 ribonucleoside-diphosphate reductase subunit M2 http://www.genome.jp/dbget-bin/www_bget?ko:K10808 P48592 1281 1.3e-139 Ribonucleoside-diphosphate reductase subunit M2 OS=Drosophila melanogaster GN=RnrS PE=1 SV=2 PF00268 Ribonucleotide reductase, small chain GO:0006144//GO:0055114//GO:0009186//GO:0006206 purine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//pyrimidine nucleobase metabolic process GO:0004748//GO:0046914 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//transition metal ion binding GO:0005971 ribonucleoside-diphosphate reductase complex KOG1567 Ribonucleotide reductase, beta subunit Cluster-8309.44912 BF_2 673.91 7.92 3848 642926029 XP_969555.3 1934 1.4e-213 PREDICTED: eukaryotic translation initiation factor 4E transporter-like isoform X3 [Tribolium castaneum]>gi|270009289|gb|EFA05737.1| eukaryotic translation initiation factor 4E nuclear import factor 1 [Tribolium castaneum] 642926028 XM_964462.3 50 2.80144e-14 PREDICTED: Tribolium castaneum eukaryotic translation initiation factor 4E transporter-like (LOC658049), transcript variant X3, mRNA -- -- -- -- Q9EST3 247 2.3e-19 Eukaryotic translation initiation factor 4E transporter OS=Mus musculus GN=Eif4enif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44916 BF_2 8.00 2.81 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44918 BF_2 18.65 1.69 750 728416727 AIY68319.1 331 2.0e-28 putative beta-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P35501 185 7.1e-13 Esterase E4 OS=Myzus persicae PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44920 BF_2 278.76 2.63 4719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08115//PF03611 SFI toxin family//PTS system sugar-specific permease component GO:0009405//GO:0009401 pathogenesis//phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.44921 BF_2 222.10 2.96 3426 237681208 NP_001153741.1 1279 1.1e-137 cleavage and polyadenylation specific factor 4, 30kDa [Tribolium castaneum]>gi|270004678|gb|EFA01126.1| hypothetical protein TcasGA2_TC010339 [Tribolium castaneum] 751792985 XM_011207858.1 143 4.98899e-66 PREDICTED: Bactrocera dorsalis cleavage and polyadenylation specificity factor subunit 4 (LOC105228160), mRNA K14404 CPSF4, YTH1 cleavage and polyadenylation specificity factor subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14404 Q9VPT8 848 4.3e-89 Cleavage and polyadenylation specificity factor subunit 4 OS=Drosophila melanogaster GN=Clp PE=1 SV=1 PF03943//PF00098//PF00642 TAP C-terminal domain//Zinc knuckle//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0051028 mRNA transport GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus KOG1040 Polyadenylation factor I complex, subunit, Yth1 (CPSF subunit) Cluster-8309.44922 BF_2 30.19 0.47 2983 478260594 ENN80297.1 378 2.9e-33 hypothetical protein YQE_03290, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44924 BF_2 958.49 5.37 7757 642939202 XP_008200380.1 3580 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 462 0 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1284 2.7e-139 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF02617//PF00002//PF02140//PF02793//PF01825 Membrane transport protein//ATP-dependent Clp protease adaptor protein ClpS//7 transmembrane receptor (Secretin family)//Galactose binding lectin domain//Hormone receptor domain//GPCR proteolysis site, GPS, motif GO:0030163//GO:0007186//GO:0055085 protein catabolic process//G-protein coupled receptor signaling pathway//transmembrane transport GO:0030246//GO:0004930 carbohydrate binding//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG4193 G protein-coupled receptors Cluster-8309.44926 BF_2 673.82 3.87 7567 642939202 XP_008200380.1 3258 0.0e+00 PREDICTED: latrophilin Cirl [Tribolium castaneum] 642939201 XM_008202158.1 168 1.40297e-79 PREDICTED: Tribolium castaneum latrophilin Cirl (LOC657847), mRNA -- -- -- -- B3MFV7 1288 9.0e-140 Latrophilin Cirl OS=Drosophila ananassae GN=Cirl PE=3 SV=1 PF03547//PF00002//PF02617//PF02140//PF02793//PF01825 Membrane transport protein//7 transmembrane receptor (Secretin family)//ATP-dependent Clp protease adaptor protein ClpS//Galactose binding lectin domain//Hormone receptor domain//GPCR proteolysis site, GPS, motif GO:0030163//GO:0055085//GO:0007186 protein catabolic process//transmembrane transport//G-protein coupled receptor signaling pathway GO:0004930//GO:0030246 G-protein coupled receptor activity//carbohydrate binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG4193 G protein-coupled receptors Cluster-8309.44929 BF_2 3.00 0.83 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44930 BF_2 572.00 6.31 4078 642926517 XP_008191989.1 2538 1.3e-283 PREDICTED: myb-binding protein 1A [Tribolium castaneum]>gi|270009066|gb|EFA05514.1| hypothetical protein TcasGA2_TC015701 [Tribolium castaneum] -- -- -- -- -- K02331 POL5, MYBBP1A DNA polymerase phi http://www.genome.jp/dbget-bin/www_bget?ko:K02331 Q6DRL5 199 9.2e-14 Myb-binding protein 1A-like protein OS=Danio rerio GN=mybbp1a PE=1 SV=1 PF02532//PF08328//PF09815//PF04931 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//Adenylosuccinate lyase C-terminal//XK-related protein//DNA polymerase phi GO:0006260//GO:0006522//GO:0006351//GO:0006188//GO:0015979//GO:0009152//GO:0006531//GO:0006144 DNA replication//alanine metabolic process//transcription, DNA-templated//IMP biosynthetic process//photosynthesis//purine ribonucleotide biosynthetic process//aspartate metabolic process//purine nucleobase metabolic process GO:0004018//GO:0003677//GO:0003887 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity//DNA binding//DNA-directed DNA polymerase activity GO:0009539//GO:0016021//GO:0042575//GO:0016020//GO:0009523 photosystem II reaction center//integral component of membrane//DNA polymerase complex//membrane//photosystem II KOG1926 Predicted regulator of rRNA gene transcription (MYB-binding protein) Cluster-8309.44931 BF_2 6.14 0.84 592 478257424 ENN77580.1 305 1.7e-25 hypothetical protein YQE_05876, partial [Dendroctonus ponderosae] -- -- -- -- -- K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 Q9TTS3 129 1.7e-06 Acetyl-CoA carboxylase 1 OS=Bos taurus GN=ACACA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44932 BF_2 32.32 2.97 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44933 BF_2 835.00 4.58 7908 642927357 XP_008195235.1 881 3.6e-91 PREDICTED: glutamate receptor ionotropic, kainate 2-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.44935 BF_2 151.49 9.08 985 546678378 ERL89011.1 852 1.0e-88 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 713 5.5e-74 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3936 Nitroreductases Cluster-8309.44936 BF_2 316.89 5.40 2742 91080237 XP_972872.1 1006 4.0e-106 PREDICTED: uncharacterized protein LOC661629 [Tribolium castaneum]>gi|270005625|gb|EFA02073.1| hypothetical protein TcasGA2_TC007708 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44939 BF_2 436.80 4.38 4459 478257777 ENN77920.1 1102 4.8e-117 hypothetical protein YQE_05597, partial [Dendroctonus ponderosae] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q99JX7 569 1.2e-56 Nuclear RNA export factor 1 OS=Mus musculus GN=Nxf1 PE=1 SV=3 PF13855//PF02136//PF03943//PF09162 Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain//TAP C-terminal domain//Tap, RNA-binding GO:0006810//GO:0006406//GO:0051028 transport//mRNA export from nucleus//mRNA transport GO:0003723//GO:0005515 RNA binding//protein binding GO:0005634//GO:0005622//GO:0005737 nucleus//intracellular//cytoplasm -- -- Cluster-8309.44941 BF_2 47.91 0.45 4743 478257777 ENN77920.1 1042 4.6e-110 hypothetical protein YQE_05597, partial [Dendroctonus ponderosae] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q9U1H9 529 5.8e-52 Nuclear RNA export factor 1 OS=Drosophila melanogaster GN=sbr PE=1 SV=2 PF13855//PF02136//PF03943//PF09162 Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain//TAP C-terminal domain//Tap, RNA-binding GO:0051028//GO:0006810//GO:0006406 mRNA transport//transport//mRNA export from nucleus GO:0005515//GO:0003723 protein binding//RNA binding GO:0005634//GO:0005737//GO:0005622 nucleus//cytoplasm//intracellular -- -- Cluster-8309.44943 BF_2 536.80 4.36 5437 642937294 XP_008198774.1 3084 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X2 [Tribolium castaneum] 642937293 XM_008200552.1 244 5.68455e-122 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X2, mRNA -- -- -- -- Q70EL1 976 9.7e-104 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF00126 Bacterial regulatory helix-turn-helix protein, lysR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.44944 BF_2 133.39 2.02 3045 357622566 EHJ73993.1 2320 1.9e-258 fanconi anemia group J protein [Danaus plexippus] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 2051 1.2e-228 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 PF13307//PF00270//PF02562//PF04851//PF06733//PF00176 Helicase C-terminal domain//DEAD/DEAH box helicase//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD_2//SNF2 family N-terminal domain GO:0006139 nucleobase-containing compound metabolic process GO:0003677//GO:0016787//GO:0005524//GO:0008026//GO:0003676//GO:0004003//GO:0016818 DNA binding//hydrolase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding//ATP-dependent DNA helicase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005657 replication fork KOG1132 Helicase of the DEAD superfamily Cluster-8309.44945 BF_2 18.04 0.31 2739 357622566 EHJ73993.1 2298 6.1e-256 fanconi anemia group J protein [Danaus plexippus] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 2042 1.2e-227 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 PF02562//PF04851//PF06733//PF00176//PF13307//PF00270 PhoH-like protein//Type III restriction enzyme, res subunit//DEAD_2//SNF2 family N-terminal domain//Helicase C-terminal domain//DEAD/DEAH box helicase GO:0006139 nucleobase-containing compound metabolic process GO:0008026//GO:0005524//GO:0003677//GO:0016787//GO:0016818//GO:0003676//GO:0004003 ATP-dependent helicase activity//ATP binding//DNA binding//hydrolase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//ATP-dependent DNA helicase activity GO:0005657 replication fork KOG1132 Helicase of the DEAD superfamily Cluster-8309.44946 BF_2 7.18 0.45 949 270006398 EFA02846.1 499 8.5e-48 regulator of telomere elongation helicase 1 [Tribolium castaneum] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 258 3.1e-21 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1132 Helicase of the DEAD superfamily Cluster-8309.44947 BF_2 114.68 0.88 5762 826470794 XP_012536083.1 1736 1.9e-190 PREDICTED: synaptotagmin-7 [Monomorium pharaonis] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 2.0e-91 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF04545//PF00168 Sigma-70, region 4//C2 domain GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677//GO:0016987 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding//sigma factor activity GO:0005667 transcription factor complex KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.4495 BF_2 62.52 0.39 7002 270014059 EFA10507.1 1113 4.0e-118 hypothetical protein TcasGA2_TC012755 [Tribolium castaneum] 194763724 XM_001963947.1 63 3.03635e-21 Drosophila ananassae GF21316 (Dana\GF21316), mRNA -- -- -- -- -- -- -- -- PF17121//PF02419 Zinc finger, C3HC4 type (RING finger)//PsbL protein GO:0015979 photosynthesis GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.44952 BF_2 120.57 0.91 5828 546682075 ERL92061.1 4401 0.0e+00 hypothetical protein D910_09383 [Dendroctonus ponderosae] -- -- -- -- -- K06101 ASH1L histone-lysine N-methyltransferase ASH1L http://www.genome.jp/dbget-bin/www_bget?ko:K06101 Q9VW15 2072 8.5e-231 Histone-lysine N-methyltransferase ash1 OS=Drosophila melanogaster GN=ash1 PE=1 SV=3 PF01426//PF00856//PF00439//PF00628//PF02378 BAH domain//SET domain//Bromodomain//PHD-finger//Phosphotransferase system, EIIC GO:0008643//GO:0009401 carbohydrate transport//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0003682//GO:0008982 protein binding//chromatin binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity GO:0000785//GO:0016020//GO:0009357 chromatin//membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.44953 BF_2 157.91 0.84 8144 642935646 XP_008198097.1 4212 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X6 [Tribolium castaneum] 642935647 XM_008199876.1 234 3.08969e-116 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.4e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF11973//PF08718//PF13180//PF00620//PF00595 NQRA C-terminal domain//Glycolipid transfer protein (GLTP)//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0046836//GO:0007165//GO:0055114//GO:0006118 glycolipid transport//signal transduction//oxidation-reduction process//obsolete electron transport GO:0005515//GO:0017089//GO:0016655//GO:0051861 protein binding//glycolipid transporter activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//glycolipid binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.44954 BF_2 274.70 2.25 5404 642918478 XP_008191493.1 5390 0.0e+00 PREDICTED: epidermal growth factor receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K04361 EGFR, ERBB1 epidermal growth factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04361 P0CY46 4398 0.0e+00 Epidermal growth factor receptor OS=Apis mellifera GN=Egfr PE=2 SV=1 PF00757//PF00069//PF06293//PF07714 Furin-like cysteine rich region//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0016773//GO:0004714//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//transmembrane receptor protein tyrosine kinase activity//protein kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.44955 BF_2 117.35 0.98 5299 642913636 XP_008201097.1 848 1.6e-87 PREDICTED: microtubule-associated protein futsch [Tribolium castaneum]>gi|270002053|gb|EEZ98500.1| hypothetical protein TcasGA2_TC001001 [Tribolium castaneum] 642913635 XM_008202875.1 61 2.9689e-20 PREDICTED: Tribolium castaneum microtubule-associated protein futsch (LOC661669), mRNA -- -- -- -- Q9W596 677 4.5e-69 Microtubule-associated protein futsch OS=Drosophila melanogaster GN=futsch PE=1 SV=4 PF01825//PF02187//PF05923 GPCR proteolysis site, GPS, motif//Growth-Arrest-Specific Protein 2 Domain//APC cysteine-rich region GO:0007050//GO:0016055 cell cycle arrest//Wnt signaling pathway -- -- GO:0016020 membrane -- -- Cluster-8309.44956 BF_2 4.00 1.85 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44959 BF_2 133.92 1.07 5525 270004788 EFA01236.1 630 3.2e-62 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44964 BF_2 137.93 1.58 3930 642920422 XP_008192343.1 2516 4.6e-281 PREDICTED: fasciclin-2 isoform X2 [Tribolium castaneum]>gi|225685461|emb|CAX64461.1| fasciclin-2 precursor [Tribolium castaneum]>gi|270005231|gb|EFA01679.1| hypothetical protein TcasGA2_TC007253 [Tribolium castaneum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1653 2.2e-182 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF05864//PF00041//PF07354//PF13895//PF16656 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006351//GO:0019497//GO:0007339//GO:0006144//GO:0006206//GO:0006771 transcription, DNA-templated//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//riboflavin metabolic process GO:0003677//GO:0003899//GO:0005515//GO:0003993//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//protein binding//acid phosphatase activity//metal ion binding GO:0005576//GO:0005730 extracellular region//nucleolus -- -- Cluster-8309.44965 BF_2 18.59 0.41 2173 270008217 EFA04665.1 867 4.1e-90 cytochrome P450-like protein [Tribolium castaneum] 194753078 XM_001958810.1 37 2.6487e-07 Drosophila ananassae GF12357 (Dana\GF12357), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 O46051 636 1.0e-64 Probable cytochrome P450 4d14 OS=Drosophila melanogaster GN=Cyp4d14 PE=3 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.44966 BF_2 788.11 8.85 4013 642934618 XP_008197739.1 2862 0.0e+00 PREDICTED: zinc finger protein 62-like [Tribolium castaneum]>gi|270013744|gb|EFA10192.1| hypothetical protein TcasGA2_TC012384 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05481 443 4.6e-42 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096//PF07776//PF03337//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Poxvirus F12L protein//C2H2-type zinc finger GO:0016032 viral process GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.44967 BF_2 13.53 0.31 2132 157108012 XP_001650037.1 194 4.4e-12 AAEL004929-PA [Aedes aegypti]>gi|108879418|gb|EAT43643.1| AAEL004929-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- O46108 151 1.8e-08 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.44969 BF_2 86.83 2.04 2069 91092598 XP_970550.1 423 1.2e-38 PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|642921812|ref|XP_008199330.1| PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|270006629|gb|EFA03077.1| hypothetical protein TcasGA2_TC010951 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9JLY7 284 6.5e-24 Dual specificity protein phosphatase 14 OS=Mus musculus GN=Dusp14 PE=2 SV=2 PF00782 Dual specificity phosphatase, catalytic domain GO:0006470 protein dephosphorylation GO:0008138 protein tyrosine/serine/threonine phosphatase activity -- -- KOG1718 Dual specificity phosphatase Cluster-8309.4497 BF_2 3.00 0.33 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03229 Alphavirus glycoprotein J GO:0019050 suppression by virus of host apoptotic process -- -- -- -- -- -- Cluster-8309.44970 BF_2 10.14 1.15 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44971 BF_2 21.06 0.41 2436 642929832 XP_008195993.1 830 9.0e-86 PREDICTED: N-acylneuraminate-9-phosphatase [Tribolium castaneum] -- -- -- -- -- K01097 NANP N-acylneuraminate-9-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01097 Q8TBE9 345 6.4e-31 N-acylneuraminate-9-phosphatase OS=Homo sapiens GN=NANP PE=1 SV=1 PF04062 ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0034314 regulation of actin filament polymerization//Arp2/3 complex-mediated actin nucleation -- -- GO:0005856//GO:0005885 cytoskeleton//Arp2/3 protein complex -- -- Cluster-8309.44972 BF_2 325.54 2.45 5837 642916405 XP_008191009.1 3474 0.0e+00 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.5e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF00018//PF14604 IRSp53/MIM homology domain//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.44974 BF_2 519.14 8.40 2872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0007187//GO:0050912//GO:0050909//GO:0007607 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.44975 BF_2 128.94 3.43 1859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44976 BF_2 1252.76 20.12 2892 759001854 AJP08639.1 1866 7.9e-206 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 475 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1636 1.5e-180 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF06293//PF00069//PF03242 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Late embryogenesis abundant protein GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.44977 BF_2 45.05 0.34 5902 546679844 ERL90232.1 1077 5.0e-114 hypothetical protein D910_07585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 554 9.1e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF03561//PF01157//PF07228 Allantoicase repeat//Ribosomal protein L21e//Stage II sporulation protein E (SpoIIE) GO:0006144//GO:0006412//GO:0000256//GO:0042254//GO:0006807 purine nucleobase metabolic process//translation//allantoin catabolic process//ribosome biogenesis//nitrogen compound metabolic process GO:0003824//GO:0004037//GO:0003735 catalytic activity//allantoicase activity//structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.44978 BF_2 210.25 2.37 3994 642926686 XP_008194968.1 2084 5.8e-231 PREDICTED: optomotor-blind protein [Tribolium castaneum] 642926685 XM_008196746.1 616 0 PREDICTED: Tribolium castaneum optomotor-blind-like (LOC661159), mRNA K10177 TBX3 T-box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10177 Q24432 1174 7.9e-127 Optomotor-blind protein OS=Drosophila melanogaster GN=bi PE=1 SV=3 PF00907//PF00018//PF06624 T-box//SH3 domain//Ribosome associated membrane protein RAMP4 GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005515 transcription factor activity, sequence-specific DNA binding//protein binding GO:0005667//GO:0005783//GO:0005634 transcription factor complex//endoplasmic reticulum//nucleus KOG3585 TBX2 and related T-box transcription factors Cluster-8309.44981 BF_2 325.68 1.66 8479 642935640 XP_008198094.1 4502 0.0e+00 PREDICTED: rho GTPase-activating protein 21-B isoform X3 [Tribolium castaneum] 642935647 XM_008199876.1 264 6.77006e-133 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.5e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF13180//PF00620//PF00595 Glycolipid transfer protein (GLTP)//PDZ domain//RhoGAP domain//PDZ domain (Also known as DHR or GLGF) GO:0007165//GO:0046836 signal transduction//glycolipid transport GO:0051861//GO:0017089//GO:0005515 glycolipid binding//glycolipid transporter activity//protein binding GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.44982 BF_2 138.15 0.78 7712 642935642 XP_008198095.1 2419 1.6e-269 PREDICTED: rho GTPase-activating protein 21-B isoform X4 [Tribolium castaneum] 642935647 XM_008199876.1 210 6.42185e-103 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X7, mRNA -- -- -- -- Q71M21 793 2.3e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF00620//PF00595//PF13180//PF11973//PF08718 RhoGAP domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain//NQRA C-terminal domain//Glycolipid transfer protein (GLTP) GO:0007165//GO:0046836//GO:0006118//GO:0055114 signal transduction//glycolipid transport//obsolete electron transport//oxidation-reduction process GO:0017089//GO:0005515//GO:0051861//GO:0016655 glycolipid transporter activity//protein binding//glycolipid binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.44984 BF_2 34.94 16.20 375 817011235 AKF11871.1 488 6.3e-47 putative juvenile hormone epoxide hydrolase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 346 7.5e-32 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.44985 BF_2 101.80 0.81 5576 91077028 XP_967318.1 1305 1.7e-140 PREDICTED: moesin/ezrin/radixin homolog 1 [Tribolium castaneum]>gi|270002017|gb|EEZ98464.1| hypothetical protein TcasGA2_TC000955 [Tribolium castaneum] -- -- -- -- -- K05762 RDX radixin http://www.genome.jp/dbget-bin/www_bget?ko:K05762 Q170J7 988 4.1e-105 Moesin/ezrin/radixin homolog 1 OS=Aedes aegypti GN=Moe PE=3 SV=1 PF00769//PF00887//PF05531//PF02911//PF00551 Ezrin/radixin/moesin family//Acyl CoA binding protein//Nucleopolyhedrovirus P10 protein//Formyl transferase, C-terminal domain//Formyl transferase GO:0009058 biosynthetic process GO:0008092//GO:0000062//GO:0016742 cytoskeletal protein binding//fatty-acyl-CoA binding//hydroxymethyl-, formyl- and related transferase activity GO:0005737//GO:0019028//GO:0019898 cytoplasm//viral capsid//extrinsic component of membrane KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.44986 BF_2 42.77 0.52 3750 642915700 XP_008190765.1 2371 2.8e-264 PREDICTED: cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like isoform X3 [Tribolium castaneum] 642915699 XM_008192543.1 487 0 PREDICTED: Tribolium castaneum cAMP-specific 3',5'-cyclic phosphodiesterase 4A-like (LOC100141919), transcript variant X3, mRNA K18436 PDE7 high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18436 P70453 486 4.4e-47 High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A OS=Mus musculus GN=Pde7a PE=2 SV=2 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.44992 BF_2 44.26 1.90 1264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.44994 BF_2 68.35 0.78 3930 665810054 XP_008553427.1 1656 2.4e-181 PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|665810056|ref|XP_008553428.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Microplitis demolitor]>gi|751201535|ref|XP_011167836.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Solenopsis invicta]>gi|780681748|ref|XP_011697692.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Wasmannia auropunctata]>gi|795064613|ref|XP_011874023.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Vollenhovia emeryi]>gi|826425920|ref|XP_012527326.1| PREDICTED: serine/threonine-protein phosphatase 2A catalytic subunit beta isoform [Monomorium pharaonis] 642933469 XM_968453.3 436 0 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (LOC662352), mRNA K04382 PPP2C serine/threonine-protein phosphatase 2A catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K04382 P62714 1626 3.0e-179 Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform OS=Homo sapiens GN=PPP2CB PE=1 SV=1 PF09514//PF00149//PF02135//PF01086//PF09494 SSXRD motif//Calcineurin-like phosphoesterase//TAZ zinc finger//Clathrin light chain//Slx4 endonuclease GO:0006281//GO:0006886//GO:0042967//GO:0016192//GO:0006260//GO:0006355//GO:0006308 DNA repair//intracellular protein transport//acyl-carrier-protein biosynthetic process//vesicle-mediated transport//DNA replication//regulation of transcription, DNA-templated//DNA catabolic process GO:0016787//GO:0005198//GO:0017108//GO:0003712//GO:0008270//GO:0004402 hydrolase activity//structural molecule activity//5'-flap endonuclease activity//transcription cofactor activity//zinc ion binding//histone acetyltransferase activity GO:0030132//GO:0030130//GO:0005634//GO:0005667//GO:0000123//GO:0033557 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle//nucleus//transcription factor complex//histone acetyltransferase complex//Slx1-Slx4 complex KOG0371 Serine/threonine protein phosphatase 2A, catalytic subunit Cluster-8309.44996 BF_2 173.10 0.47 15767 91093435 XP_969667.1 5244 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1396 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 3755 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF00889//PF00168//PF08236//PF00130//PF07065//PF11968//PF03081//PF12169//PF01104//PF11112 Elongation factor TS//C2 domain//SRI (Set2 Rpb1 interacting) domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//D123//Putative methyltransferase (DUF3321)//Exo70 exocyst complex subunit//DNA polymerase III subunits gamma and tau domain III//Bunyavirus non-structural protein NS-s//Pyocin activator protein PrtN GO:0016032//GO:0006887//GO:0006479//GO:0006414//GO:0006448//GO:0034968//GO:0006355//GO:0006260//GO:0007049//GO:0000154//GO:0035556//GO:0006554//GO:0006396 viral process//exocytosis//protein methylation//translational elongation//regulation of translational elongation//histone lysine methylation//regulation of transcription, DNA-templated//DNA replication//cell cycle//rRNA modification//intracellular signal transduction//lysine catabolic process//RNA processing GO:0018024//GO:0005515//GO:0003887//GO:0003746//GO:0016433 histone-lysine N-methyltransferase activity//protein binding//DNA-directed DNA polymerase activity//translation elongation factor activity//rRNA (adenine) methyltransferase activity GO:0005694//GO:0000145//GO:0042575//GO:0005840//GO:0005622 chromosome//exocyst//DNA polymerase complex//ribosome//intracellular KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44997 BF_2 216.33 1.13 8267 91093435 XP_969667.1 5865 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1530 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 4289 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF00168//PF08236//PF03310//PF01104//PF04623//PF11112//PF00130//PF11968//PF03081//PF07065//PF12169 C2 domain//SRI (Set2 Rpb1 interacting) domain//Caulimovirus DNA-binding protein//Bunyavirus non-structural protein NS-s//Adenovirus E1B protein N-terminus//Pyocin activator protein PrtN//Phorbol esters/diacylglycerol binding domain (C1 domain)//Putative methyltransferase (DUF3321)//Exo70 exocyst complex subunit//D123//DNA polymerase III subunits gamma and tau domain III GO:0006887//GO:0006479//GO:0009605//GO:0016032//GO:0006260//GO:0006355//GO:0006554//GO:0006396//GO:0007049//GO:0000154//GO:0035556//GO:0034968 exocytosis//protein methylation//response to external stimulus//viral process//DNA replication//regulation of transcription, DNA-templated//lysine catabolic process//RNA processing//cell cycle//rRNA modification//intracellular signal transduction//histone lysine methylation GO:0003677//GO:0018024//GO:0005515//GO:0003887//GO:0016433 DNA binding//histone-lysine N-methyltransferase activity//protein binding//DNA-directed DNA polymerase activity//rRNA (adenine) methyltransferase activity GO:0005694//GO:0000145//GO:0042575 chromosome//exocyst//DNA polymerase complex KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44998 BF_2 509.79 1.38 15735 91093435 XP_969667.1 5244 0.0e+00 PREDICTED: protein unc-13 homolog B [Tribolium castaneum] 642938496 XM_964574.2 1396 0 PREDICTED: Tribolium castaneum protein unc-13 homolog B (LOC658165), mRNA K15293 UNC13, MUNC13 protein unc-13 http://www.genome.jp/dbget-bin/www_bget?ko:K15293 O14795 3755 0.0e+00 Protein unc-13 homolog B OS=Homo sapiens GN=UNC13B PE=1 SV=2 PF12169//PF00130//PF11968//PF07065//PF03081//PF11112//PF01104//PF00889//PF00168//PF08236 DNA polymerase III subunits gamma and tau domain III//Phorbol esters/diacylglycerol binding domain (C1 domain)//Putative methyltransferase (DUF3321)//D123//Exo70 exocyst complex subunit//Pyocin activator protein PrtN//Bunyavirus non-structural protein NS-s//Elongation factor TS//C2 domain//SRI (Set2 Rpb1 interacting) domain GO:0016032//GO:0006887//GO:0006479//GO:0006448//GO:0034968//GO:0006414//GO:0007049//GO:0000154//GO:0035556//GO:0006554//GO:0006396//GO:0006355//GO:0006260 viral process//exocytosis//protein methylation//regulation of translational elongation//histone lysine methylation//translational elongation//cell cycle//rRNA modification//intracellular signal transduction//lysine catabolic process//RNA processing//regulation of transcription, DNA-templated//DNA replication GO:0005515//GO:0003887//GO:0018024//GO:0003746//GO:0016433 protein binding//DNA-directed DNA polymerase activity//histone-lysine N-methyltransferase activity//translation elongation factor activity//rRNA (adenine) methyltransferase activity GO:0005694//GO:0000145//GO:0042575//GO:0005840//GO:0005622 chromosome//exocyst//DNA polymerase complex//ribosome//intracellular KOG1011 Neurotransmitter release regulator, UNC-13 Cluster-8309.44999 BF_2 229.44 2.83 3674 478253263 ENN73634.1 2771 1.2e-310 hypothetical protein YQE_09881, partial [Dendroctonus ponderosae] -- -- -- -- -- K00771 XYLT protein xylosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00771 Q5QQ53 2068 1.6e-230 Xylosyltransferase oxt OS=Drosophila pseudoobscura pseudoobscura GN=oxt PE=2 SV=1 PF12529//PF02485 Xylosyltransferase C terminal//Core-2/I-Branching enzyme GO:0030206//GO:0006024 chondroitin sulfate biosynthetic process//glycosaminoglycan biosynthetic process GO:0008375//GO:0030158 acetylglucosaminyltransferase activity//protein xylosyltransferase activity GO:0016020 membrane KOG0799 Branching enzyme Cluster-8309.45 BF_2 2.56 0.32 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45000 BF_2 13.29 1.50 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45006 BF_2 202.99 1.69 5303 646710672 KDR16118.1 400 1.4e-35 hypothetical protein L798_10008 [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 383 5.5e-35 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13912//PF07776//PF01113//PF13465//PF00096//PF08533//PF00044 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Dihydrodipicolinate reductase, N-terminus//Zinc-finger double domain//Zinc finger, C2H2 type//Beta-galactosidase C-terminal domain//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain GO:0006012//GO:0009089//GO:0006027//GO:0009085//GO:0046486//GO:0006687//GO:0055114 galactose metabolic process//lysine biosynthetic process via diaminopimelate//glycosaminoglycan catabolic process//lysine biosynthetic process//glycerolipid metabolic process//glycosphingolipid metabolic process//oxidation-reduction process GO:0004565//GO:0008839//GO:0008270//GO:0016620//GO:0046872 beta-galactosidase activity//4-hydroxy-tetrahydrodipicolinate reductase//zinc ion binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//metal ion binding GO:0009341//GO:0005634 beta-galactosidase complex//nucleus -- -- Cluster-8309.45008 BF_2 88.46 0.71 5486 91082499 XP_972877.1 1497 9.2e-163 PREDICTED: nuclear pore complex protein Nup93 [Tribolium castaneum]>gi|270007136|gb|EFA03584.1| hypothetical protein TcasGA2_TC013667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU29 852 2.4e-89 Nuclear pore complex protein Nup93 OS=Danio rerio GN=dye PE=2 SV=1 PF04097//PF16276//PF00569//PF01256//PF06701//PF00637//PF02066//PF04121 Nup93/Nic96//Nucleophosmin C-terminal domain//Zinc finger, ZZ type//Carbohydrate kinase//Mib_herc2//Region in Clathrin and VPS//Metallothionein family 11//Nuclear pore protein 84 / 107 GO:0006886//GO:0016567//GO:0006810//GO:0016192 intracellular protein transport//protein ubiquitination//transport//vesicle-mediated transport GO:0004842//GO:0052855//GO:0005507//GO:0046872//GO:0003676//GO:0008270 ubiquitin-protein transferase activity//ADP-dependent NAD(P)H-hydrate dehydratase activity//copper ion binding//metal ion binding//nucleic acid binding//zinc ion binding GO:0005643 nuclear pore -- -- Cluster-8309.45009 BF_2 296.24 5.91 2385 110767819 XP_393546.3 2235 1.1e-248 PREDICTED: potassium voltage-gated channel protein Shab-like isoform X6 [Apis mellifera] 189008483 EU616810.1 323 3.00309e-166 Tribolium castaneum shaker cognate b (Shab) gene, exon 2 and partial cds K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1985 4.3e-221 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF02214//PF00520//PF13374 BTB/POZ domain//Ion transport protein//Tetratricopeptide repeat GO:0055085//GO:0051260//GO:0006811 transmembrane transport//protein homooligomerization//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane -- -- Cluster-8309.4501 BF_2 5.03 0.34 904 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45012 BF_2 252.18 1.65 6669 91080389 XP_966373.1 6388 0.0e+00 PREDICTED: teneurin-a, partial [Tribolium castaneum] 194768035 XM_001966084.1 267 1.14314e-134 Drosophila ananassae GF19389 (Dana\GF19389), mRNA -- -- -- -- Q9VYN8 4159 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.45013 BF_2 508.59 3.96 5662 91080389 XP_966373.1 6385 0.0e+00 PREDICTED: teneurin-a, partial [Tribolium castaneum] 194768035 XM_001966084.1 267 9.70046e-135 Drosophila ananassae GF19389 (Dana\GF19389), mRNA -- -- -- -- Q9VYN8 4159 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.45016 BF_2 144.61 1.04 6078 91080389 XP_966373.1 6388 0.0e+00 PREDICTED: teneurin-a, partial [Tribolium castaneum] 194768035 XM_001966084.1 267 1.04177e-134 Drosophila ananassae GF19389 (Dana\GF19389), mRNA -- -- -- -- Q9VYN8 4159 0.0e+00 Teneurin-a OS=Drosophila melanogaster GN=Ten-a PE=1 SV=2 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG4659 Uncharacterized conserved protein (Rhs family) Cluster-8309.45018 BF_2 111.71 0.88 5579 642931607 XP_008196654.1 4556 0.0e+00 PREDICTED: protein argonaute-2 isoform X3 [Tribolium castaneum] 723941700 KF986386.1 853 0 Graminella nigrifrons argonaute 2 mRNA, partial cds K11593 ELF2C, AGO eukaryotic translation initiation factor 2C http://www.genome.jp/dbget-bin/www_bget?ko:K11593 Q9UKV8 3318 0.0e+00 Protein argonaute-2 OS=Homo sapiens GN=AGO2 PE=1 SV=3 PF02171//PF02170//PF04810 Piwi domain//PAZ domain//Sec23/Sec24 zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0008270//GO:0003676 protein binding//zinc ion binding//nucleic acid binding GO:0030127 COPII vesicle coat KOG1041 Translation initiation factor 2C (eIF-2C) and related proteins Cluster-8309.45019 BF_2 107.67 2.70 1957 642916559 XP_008191693.1 1581 6.0e-173 PREDICTED: uncharacterized protein LOC103312554 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45020 BF_2 44.54 0.45 4422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45022 BF_2 55.52 2.15 1367 645020639 XP_008207241.1 180 1.2e-10 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45023 BF_2 44.48 0.39 5107 478260665 ENN80362.1 1376 9.2e-149 hypothetical protein YQE_03221, partial [Dendroctonus ponderosae]>gi|478269621|gb|ENN83368.1| hypothetical protein YQE_00276, partial [Dendroctonus ponderosae]>gi|546683697|gb|ERL93475.1| hypothetical protein D910_10766 [Dendroctonus ponderosae] -- -- -- -- -- K08592 SENP1 sentrin-specific protease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08592 Q9VXP4 724 1.5e-74 Platelet-activating factor acetylhydrolase IB subunit beta homolog OS=Drosophila melanogaster GN=Paf-AHalpha PE=1 SV=1 PF00657//PF00770//PF02902 GDSL-like Lipase/Acylhydrolase//Adenovirus endoprotease//Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0016788//GO:0008234//GO:0004197 hydrolase activity, acting on ester bonds//cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG0778 Protease, Ulp1 family Cluster-8309.45024 BF_2 15.66 0.36 2103 189238926 XP_001811313.1 401 4.3e-36 PREDICTED: acyl-CoA-binding domain-containing protein 5A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q641E3 313 2.9e-27 Acyl-CoA-binding domain-containing protein 5 OS=Xenopus laevis GN=acbd5 PE=2 SV=1 PF00887 Acyl CoA binding protein -- -- GO:0000062 fatty-acyl-CoA binding -- -- KOG0817 Acyl-CoA-binding protein Cluster-8309.45027 BF_2 4.40 0.34 822 642939755 XP_969161.2 266 7.6e-21 PREDICTED: dnaJ homolog subfamily C member 3 [Tribolium castaneum] -- -- -- -- -- K09523 DNAJC3 DnaJ homolog subfamily C member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09523 Q9R0T3 143 5.8e-08 DnaJ homolog subfamily C member 3 OS=Rattus norvegicus GN=Dnajc3 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG0624 dsRNA-activated protein kinase inhibitor P58, contains TPR and DnaJ domains Cluster-8309.45029 BF_2 173.52 7.14 1304 332374520 AEE62401.1 597 5.0e-59 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45031 BF_2 26.05 1.15 1233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45034 BF_2 28.43 1.59 1035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45037 BF_2 105.86 0.84 5534 642918693 XP_008191540.1 2619 7.3e-293 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1276 1.6e-138 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF00788//PF15200 Ras association (RalGDS/AF-6) domain//Keratinocyte differentiation-associated GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.45041 BF_2 210.93 2.88 3348 121583752 NP_001073568.1 1122 1.7e-119 cuticular protein analogous to peritrophins 3-D2 precursor [Tribolium castaneum]>gi|119387892|gb|ABL73931.1| obstractor D [Tribolium castaneum]>gi|270002339|gb|EEZ98786.1| hypothetical protein TcasGA2_TC001350 [Tribolium castaneum] 815806463 XM_012368582.1 219 2.75255e-108 PREDICTED: Linepithema humile chondroitin proteoglycan-2-like (LOC105673158), mRNA -- -- -- -- Q86UB9 201 4.4e-14 Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.45042 BF_2 885.97 12.23 3318 121583752 NP_001073568.1 1122 1.7e-119 cuticular protein analogous to peritrophins 3-D2 precursor [Tribolium castaneum]>gi|119387892|gb|ABL73931.1| obstractor D [Tribolium castaneum]>gi|270002339|gb|EEZ98786.1| hypothetical protein TcasGA2_TC001350 [Tribolium castaneum] 815806463 XM_012368582.1 219 2.72762e-108 PREDICTED: Linepithema humile chondroitin proteoglycan-2-like (LOC105673158), mRNA -- -- -- -- Q86UB9 201 4.4e-14 Transmembrane protein 135 OS=Homo sapiens GN=TMEM135 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.45043 BF_2 298.74 1.38 9369 642921537 XP_967662.3 1215 7.9e-130 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270006324|gb|EFA02772.1| hypothetical protein TcasGA2_TC008507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWF2 488 6.5e-47 Supporter of activation of yellow protein OS=Drosophila melanogaster GN=e(y)3 PE=2 SV=3 -- -- -- -- GO:0003677 DNA binding -- -- KOG1512 PHD Zn-finger protein Cluster-8309.45044 BF_2 513.11 3.32 6760 546681968 ERL91964.1 676 1.8e-67 hypothetical protein D910_09287 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 139 1.4e-06 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF09472//PF04838 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Baculoviridae late expression factor 5 GO:0015948//GO:0006355//GO:0046656 methanogenesis//regulation of transcription, DNA-templated//folic acid biosynthetic process GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.45045 BF_2 580.26 3.49 7236 642921537 XP_967662.3 1215 6.1e-130 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270006324|gb|EFA02772.1| hypothetical protein TcasGA2_TC008507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWF2 488 5.0e-47 Supporter of activation of yellow protein OS=Drosophila melanogaster GN=e(y)3 PE=2 SV=3 -- -- -- -- GO:0003677 DNA binding -- -- KOG1512 PHD Zn-finger protein Cluster-8309.45046 BF_2 473.00 24.65 1090 478252983 ENN73365.1 591 2.1e-58 hypothetical protein YQE_10015, partial [Dendroctonus ponderosae]>gi|546679350|gb|ERL89825.1| hypothetical protein D910_07185 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P51909 223 4.0e-17 Apolipoprotein D OS=Cavia porcellus GN=APOD PE=2 SV=1 PF03973 Triabin GO:0030682 evasion or tolerance of host defense response -- -- -- -- -- -- Cluster-8309.45048 BF_2 84.00 3.35 1335 768437701 XP_011560403.1 311 7.5e-26 PREDICTED: zinc finger protein Xfin-like [Plutella xylostella]>gi|768437703|ref|XP_011560404.1| PREDICTED: zinc finger protein Xfin-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q9W747 217 2.4e-16 Zinc finger protein draculin OS=Danio rerio GN=drl PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.45049 BF_2 74.37 0.72 4589 546684929 ERL94511.1 246 8.9e-18 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF01363 Zinc-finger associated domain (zf-AD)//FYVE zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45050 BF_2 15.57 1.35 771 546684929 ERL94511.1 201 2.5e-13 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF17123 Zinc-finger associated domain (zf-AD)//RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45052 BF_2 44.13 0.60 3340 642923250 XP_008193676.1 367 6.0e-32 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 313 4.5e-27 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF14634//PF00097//PF00569//PF06701//PF15898//PF13639//PF07663 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc finger, ZZ type//Mib_herc2//cGMP-dependent protein kinase interacting domain//Ring finger domain//Sorbitol phosphotransferase enzyme II C-terminus GO:0016567//GO:0009401//GO:0008643 protein ubiquitination//phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0004842//GO:0005515//GO:0008270//GO:0019901//GO:0008982//GO:0046872 ubiquitin-protein transferase activity//protein binding//zinc ion binding//protein kinase binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//metal ion binding GO:0016021//GO:0009357 integral component of membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.45053 BF_2 34.32 1.70 1132 642923250 XP_008193676.1 243 4.9e-18 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q96AX9 202 1.1e-14 E3 ubiquitin-protein ligase MIB2 OS=Homo sapiens GN=MIB2 PE=1 SV=3 PF06701//PF13639//PF14634//PF00097 Mib_herc2//Ring finger domain//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0005515//GO:0046872//GO:0004842//GO:0008270 protein binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding -- -- -- -- Cluster-8309.45055 BF_2 27.54 4.45 546 478260276 ENN80028.1 197 5.1e-13 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q99KE8 133 5.5e-07 Zinc finger protein 64 OS=Mus musculus GN=Zfp64 PE=2 SV=1 PF00096//PF13465//PF04988//PF02150//PF07649 Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//RNA polymerases M/15 Kd subunit//C1-like domain GO:0006206//GO:0055114//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//oxidation-reduction process//transcription, DNA-templated//purine nucleobase metabolic process GO:0047134//GO:0046872//GO:0003899//GO:0003677 protein-disulfide reductase activity//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.45057 BF_2 23.00 0.97 1277 642937652 XP_966876.3 224 8.8e-16 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 145 5.2e-08 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF16866//PF07649//PF06397//PF02150//PF04988//PF00096//PF13465 PHD-finger//C1-like domain//Desulfoferrodoxin, N-terminal domain//RNA polymerases M/15 Kd subunit//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006351//GO:0006144//GO:0006206//GO:0055114 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0003899//GO:0003677//GO:0005515//GO:0046872//GO:0047134//GO:0005506 DNA-directed RNA polymerase activity//DNA binding//protein binding//metal ion binding//protein-disulfide reductase activity//iron ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.45058 BF_2 438.28 3.34 5775 780110017 XP_011676369.1 240 5.6e-17 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15504 ANKRD52 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K15504 Q4UMH6 207 1.5e-14 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF07776//PF00023//PF06213//PF13606 Zinc-finger associated domain (zf-AD)//Ankyrin repeat//Cobalamin biosynthesis protein CobT//Ankyrin repeat GO:0009236 cobalamin biosynthetic process GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.45060 BF_2 1325.17 14.59 4086 642927788 XP_008195406.1 2047 1.2e-226 PREDICTED: pre-mRNA-processing factor 39 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13217 PRPF39, PRP39 pre-mRNA-processing factor 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13217 Q1JPZ7 1005 3.2e-107 Pre-mRNA-processing factor 39 OS=Danio rerio GN=prpf39 PE=2 SV=2 PF13414//PF13174//PF02978//PF13181//PF00515//PF02184 TPR repeat//Tetratricopeptide repeat//Signal peptide binding domain//Tetratricopeptide repeat//Tetratricopeptide repeat//HAT (Half-A-TPR) repeat GO:0006614//GO:0006396 SRP-dependent cotranslational protein targeting to membrane//RNA processing GO:0008312//GO:0005515 7S RNA binding//protein binding GO:0005622//GO:0048500 intracellular//signal recognition particle KOG1258 mRNA processing protein Cluster-8309.45061 BF_2 90.35 0.69 5763 91090858 XP_967143.1 942 2.2e-98 PREDICTED: annexin B9 isoform X1 [Tribolium castaneum]>gi|270013217|gb|EFA09665.1| hypothetical protein TcasGA2_TC011791 [Tribolium castaneum] 688710729 LL320824.1 36 2.55101e-06 Anisakis simplex genome assembly A_simplex ,scaffold ASIM_scaffold0001563 K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 Q9VXG4 722 2.9e-74 Annexin B11 OS=Drosophila melanogaster GN=AnxB11 PE=2 SV=2 PF00270//PF01580//PF00191//PF06733//PF00580//PF02562//PF04851 DEAD/DEAH box helicase//FtsK/SpoIIIE family//Annexin//DEAD_2//UvrD/REP helicase N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit -- -- GO:0004003//GO:0003676//GO:0005509//GO:0000166//GO:0005544//GO:0003677//GO:0016787//GO:0005524 ATP-dependent DNA helicase activity//nucleic acid binding//calcium ion binding//nucleotide binding//calcium-dependent phospholipid binding//DNA binding//hydrolase activity//ATP binding GO:0005657 replication fork KOG0819 Annexin Cluster-8309.45063 BF_2 417.00 8.87 2253 546681148 ERL91298.1 756 3.2e-77 hypothetical protein D910_08631 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B4USX2 130 5.1e-06 Serpin B10 OS=Otolemur garnettii GN=SERPINB10 PE=3 SV=1 PF02914 Bacteriophage Mu transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.45064 BF_2 7.01 0.58 793 91078850 XP_971848.1 674 3.6e-68 PREDICTED: uncharacterized protein LOC660531 [Tribolium castaneum]>gi|270004130|gb|EFA00578.1| hypothetical protein TcasGA2_TC003448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0042318 penicillin biosynthetic process -- -- -- -- -- -- Cluster-8309.45066 BF_2 671.84 4.69 6275 642930820 XP_008196102.1 4113 0.0e+00 PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|642930822|ref|XP_008196103.1| PREDICTED: GTPase-activating protein CdGAPr [Tribolium castaneum]>gi|270011956|gb|EFA08404.1| hypothetical protein TcasGA2_TC006051 [Tribolium castaneum] 194760457 XM_001962421.1 42 1.28325e-09 Drosophila ananassae GF15474 (Dana\GF15474), mRNA -- -- -- -- Q9VIS1 1396 2.2e-152 GTPase-activating protein CdGAPr OS=Drosophila melanogaster GN=CdGAPr PE=1 SV=2 PF01929//PF00787//PF00018//PF00620//PF14604 Ribosomal protein L14//PX domain//SH3 domain//RhoGAP domain//Variant SH3 domain GO:0007165//GO:0006412//GO:0042254//GO:0007154 signal transduction//translation//ribosome biogenesis//cell communication GO:0035091//GO:0005515//GO:0003735 phosphatidylinositol binding//protein binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1449 Predicted Rho GTPase-activating protein CdGAPr Cluster-8309.45068 BF_2 291.11 1.10 11310 642937629 XP_008198876.1 4353 0.0e+00 PREDICTED: tubby-related protein 4 [Tribolium castaneum] 462288762 APGK01055065.1 72 4.87976e-26 Dendroctonus ponderosae Seq01055075, whole genome shotgun sequence -- -- -- -- Q9JIL5 1348 1.5e-146 Tubby-related protein 4 OS=Mus musculus GN=Tulp4 PE=2 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- KOG2503 Tubby superfamily protein TULP4 Cluster-8309.45071 BF_2 62.51 0.74 3811 577754854 AHH86056.1 1964 4.5e-217 glycoside hydrolase family 31 [Phaedon cochleariae] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 875 3.5e-92 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01607//PF01055 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 31 GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.45072 BF_2 870.04 8.13 4765 642919813 XP_008192079.1 4713 0.0e+00 PREDICTED: homeodomain-interacting protein kinase 2 isoform X4 [Tribolium castaneum] 642919812 XM_008193857.1 759 0 PREDICTED: Tribolium castaneum homeodomain-interacting protein kinase 2 (LOC661500), transcript variant X4, mRNA K08826 HIPK homeodomain interacting protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08826 Q9H2X6 1895 2.3e-210 Homeodomain-interacting protein kinase 2 OS=Homo sapiens GN=HIPK2 PE=1 SV=2 PF05445//PF00069//PF06293//PF07714 Poxvirus serine/threonine protein kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.45074 BF_2 69.01 3.46 1122 270012026 EFA08474.1 702 2.9e-71 hypothetical protein TcasGA2_TC006124 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 487 1.0e-47 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45075 BF_2 26.92 0.62 2108 91084843 XP_966905.1 1174 1.0e-125 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 793 6.3e-83 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01073//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008207//GO:0006694//GO:0055114//GO:0008209//GO:0008210 C21-steroid hormone metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//estrogen metabolic process GO:0080019//GO:0003854//GO:0050662//GO:0003824//GO:0016616 fatty-acyl-CoA reductase (alcohol-forming) activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.45076 BF_2 556.92 4.95 4994 91076832 XP_974636.1 4089 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 224 6.84648e-111 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 Q9Y6R4 854 1.3e-89 Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens GN=MAP3K4 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0000166//GO:0004672 ATP binding//nucleotide binding//protein kinase activity -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.45077 BF_2 716.56 5.91 5361 642918693 XP_008191540.1 2619 7.1e-293 PREDICTED: protein sprint isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 1276 1.6e-138 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200//PF00788 Keratinocyte differentiation-associated//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.45078 BF_2 43.86 2.09 1166 642923532 XP_969777.2 291 1.4e-23 PREDICTED: GPALPP motifs-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IXQ4 171 4.6e-11 GPALPP motifs-containing protein 1 OS=Homo sapiens GN=GPALPP1 PE=1 SV=1 PF06638//PF06687 Strabismus protein//SUR7/PalI family GO:0007275 multicellular organismal development -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.45082 BF_2 119.83 2.36 2415 91092388 XP_968476.1 2123 1.0e-235 PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|642930639|ref|XP_008199205.1| PREDICTED: uncharacterized protein LOC656883 [Tribolium castaneum]>gi|270011253|gb|EFA07701.1| hypothetical protein TcasGA2_TC002177 [Tribolium castaneum] 645007828 XM_008205498.1 63 1.0382e-21 PREDICTED: Nasonia vitripennis uncharacterized LOC100118938 (LOC100118938), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45083 BF_2 709.27 13.35 2510 478254210 ENN74475.1 2197 2.9e-244 hypothetical protein YQE_08921, partial [Dendroctonus ponderosae] -- -- -- -- -- K02085 APC adenomatosis polyposis coli protein http://www.genome.jp/dbget-bin/www_bget?ko:K02085 Q61315 1246 2.2e-135 Adenomatous polyposis coli protein OS=Mus musculus GN=Apc PE=1 SV=1 PF02985//PF05972//PF00514//PF10280 HEAT repeat//APC 15 residue motif//Armadillo/beta-catenin-like repeat//Mediator complex protein GO:0006357//GO:0016055 regulation of transcription from RNA polymerase II promoter//Wnt signaling pathway GO:0008013//GO:0001104//GO:0005515 beta-catenin binding//RNA polymerase II transcription cofactor activity//protein binding GO:0016592//GO:0016342 mediator complex//catenin complex KOG2122 Beta-catenin-binding protein APC, contains ARM repeats Cluster-8309.45084 BF_2 105.55 4.54 1260 189240236 XP_001811057.1 1774 1.6e-195 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 54 5.38161e-17 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q7ZYD5 1064 1.4e-114 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Xenopus laevis GN=slc25a25 PE=2 SV=1 PF13202//PF13499//PF10591//PF13833//PF00036//PF13405 EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0036 Predicted mitochondrial carrier protein Cluster-8309.45086 BF_2 20.04 0.32 2887 91088643 XP_974406.1 376 4.7e-33 PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|642931990|ref|XP_008196810.1| PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|642931992|ref|XP_008196811.1| PREDICTED: uncharacterized protein LOC663257 [Tribolium castaneum]>gi|270011686|gb|EFA08134.1| hypothetical protein TcasGA2_TC005738 [Tribolium castaneum] -- -- -- -- -- K12163 ANUBL1 AN1-type zinc finger and ubiquitin domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12163 -- -- -- -- PF04023//PF14560//PF00240 FeoA domain//Ubiquitin-like domain//Ubiquitin family -- -- GO:0046914//GO:0008270//GO:0046872//GO:0005515 transition metal ion binding//zinc ion binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.45087 BF_2 330.03 4.04 3708 478250393 ENN70888.1 2076 4.5e-230 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 751 8.2e-78 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.45088 BF_2 147.91 3.43 2090 478254798 ENN75034.1 1459 9.0e-159 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 170 2.96172e-81 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 980 1.3e-104 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.45090 BF_2 59.33 0.81 3349 642925753 XP_008201610.1 903 4.3e-94 PREDICTED: protein GUCD1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K02264 COX5A cytochrome c oxidase subunit 5a http://www.genome.jp/dbget-bin/www_bget?ko:K02264 Q94514 421 1.4e-39 Cytochrome c oxidase subunit 5A, mitochondrial OS=Drosophila melanogaster GN=CoVa PE=2 SV=2 PF02284//PF03412 Cytochrome c oxidase subunit Va//Peptidase C39 family GO:0006123//GO:0015992//GO:0006508 mitochondrial electron transport, cytochrome c to oxygen//proton transport//proteolysis GO:0005524//GO:0004129//GO:0008233 ATP binding//cytochrome-c oxidase activity//peptidase activity GO:0045277//GO:0016021//GO:0005743 respiratory chain complex IV//integral component of membrane//mitochondrial inner membrane KOG4077 Cytochrome c oxidase, subunit Va/COX6 Cluster-8309.45091 BF_2 42.00 39.58 322 642922463 XP_008193182.1 277 1.6e-22 PREDICTED: integrin beta-PS [Tribolium castaneum] -- -- -- -- -- K06493 ITGB3 integrin beta 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06493 P11584 223 1.2e-17 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1226 Integrin beta subunit (N-terminal portion of extracellular region) Cluster-8309.45092 BF_2 23.89 0.88 1423 642919702 XP_008192028.1 994 5.1e-105 PREDICTED: inositol-trisphosphate 3-kinase A-like [Tribolium castaneum] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 638 4.0e-65 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.45095 BF_2 241.90 5.73 2054 478255270 ENN75499.1 618 2.9e-61 hypothetical protein YQE_08048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.45097 BF_2 288.78 3.80 3464 91091214 XP_966756.1 2881 0.0e+00 PREDICTED: WD repeat-containing protein 24 [Tribolium castaneum]>gi|270014105|gb|EFA10553.1| hypothetical protein TcasGA2_TC012809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZX22 1413 1.3e-154 WD repeat-containing protein 24 OS=Xenopus laevis GN=wdr24 PE=2 SV=1 PF00400 WD domain, G-beta repeat GO:0007165//GO:0016558 signal transduction//protein import into peroxisome matrix GO:0005053//GO:0005515 peroxisome matrix targeting signal-2 binding//protein binding GO:0005777//GO:0005781 peroxisome//obsolete peroxisome targeting signal receptor complex KOG0269 WD40 repeat-containing protein Cluster-8309.45098 BF_2 408.54 13.61 1543 546673667 ERL85231.1 1312 7.3e-142 hypothetical protein D910_02652 [Dendroctonus ponderosae] -- -- -- -- -- K06990 K06990 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06990 Q803S3 958 3.4e-102 Protein MEMO1 OS=Danio rerio GN=memo1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3086 Predicted dioxygenase Cluster-8309.45099 BF_2 505.01 3.36 6568 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028//PF14249 Cadherin domain//Tocopherol cyclase GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0009976//GO:0005509 tocopherol cyclase activity//calcium ion binding GO:0016020 membrane -- -- Cluster-8309.4510 BF_2 6.00 0.33 1040 861635019 KMQ91440.1 498 1.2e-47 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q3ZCU0 242 2.4e-19 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45100 BF_2 124.99 3.20 1919 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07657 N terminus of Notch ligand GO:0007219//GO:0007275 Notch signaling pathway//multicellular organismal development -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45101 BF_2 1911.02 40.44 2264 478256359 ENN76549.1 2315 5.3e-258 hypothetical protein YQE_07000, partial [Dendroctonus ponderosae]>gi|546680788|gb|ERL90994.1| hypothetical protein D910_08336 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 274 1.0e-22 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45103 BF_2 45.37 0.35 5703 642926862 XP_008195043.1 709 2.3e-71 PREDICTED: uncharacterized protein LOC103313479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 139 1.2e-06 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45104 BF_2 458.14 4.61 4440 270006116 EFA02564.1 933 1.9e-97 hypothetical protein TcasGA2_TC008273 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q7ZYQ3 470 3.8e-45 Choline/ethanolaminephosphotransferase 1 OS=Xenopus laevis GN=cept1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.45105 BF_2 109.00 1.43 3482 642920784 XP_008192559.1 186 6.1e-11 PREDICTED: choline/ethanolaminephosphotransferase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00871 Acetokinase family GO:0008152//GO:0016310 metabolic process//phosphorylation GO:0016774//GO:0016301 phosphotransferase activity, carboxyl group as acceptor//kinase activity GO:0005622 intracellular -- -- Cluster-8309.45107 BF_2 306.69 2.16 6239 270006116 EFA02564.1 908 2.1e-94 hypothetical protein TcasGA2_TC008273 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q7ZYQ3 470 5.3e-45 Choline/ethanolaminephosphotransferase 1 OS=Xenopus laevis GN=cept1 PE=2 SV=1 PF01066 CDP-alcohol phosphatidyltransferase GO:0008654 phospholipid biosynthetic process GO:0016780 phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.45108 BF_2 46.24 3.50 840 642920788 XP_008192561.1 234 4.0e-17 PREDICTED: cholinephosphotransferase 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45109 BF_2 34.92 0.35 4417 270006116 EFA02564.1 251 2.3e-18 hypothetical protein TcasGA2_TC008273 [Tribolium castaneum] -- -- -- -- -- K13644 CEPT1 choline/ethanolamine phosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13644 Q7ZYQ3 157 7.4e-09 Choline/ethanolaminephosphotransferase 1 OS=Xenopus laevis GN=cept1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.45111 BF_2 29.13 1.02 1487 478262463 ENN81134.1 908 5.0e-95 hypothetical protein YQE_02502, partial [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q06AU5 721 9.9e-75 Ras-related protein Rab-32 OS=Sus scrofa GN=RAB32 PE=2 SV=1 PF04670//PF10662//PF00071//PF00503//PF02367//PF00025//PF01926//PF08477 Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//G-protein alpha subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ADP-ribosylation factor family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007165//GO:0006576//GO:0007186//GO:0002949//GO:0007264 signal transduction//cellular biogenic amine metabolic process//G-protein coupled receptor signaling pathway//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0031683//GO:0005524//GO:0003924//GO:0004871//GO:0019001//GO:0005525 G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//signal transducer activity//guanyl nucleotide binding//GTP binding -- -- KOG0394 Ras-related GTPase Cluster-8309.45119 BF_2 72.23 0.41 7731 546674242 ERL85667.1 1294 4.5e-139 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q6DD32 793 2.3e-82 RING finger protein 121 OS=Xenopus laevis GN=rnf121 PE=2 SV=1 PF00097//PF17123//PF12678//PF14634//PF12861//PF13639//PF07967 Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//C3HC zinc finger-like GO:0016567 protein ubiquitination GO:0004842//GO:0046872//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//metal ion binding//protein binding//zinc ion binding GO:0005680//GO:0005634 anaphase-promoting complex//nucleus KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.4512 BF_2 8.00 0.59 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45124 BF_2 270.16 2.37 5052 270000843 EEZ97290.1 2313 2.0e-257 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 377 0 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 1079 1.0e-115 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF01369 Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.45125 BF_2 422.06 4.38 4320 270000843 EEZ97290.1 2031 8.7e-225 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 377 0 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 1079 8.8e-116 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF00595//PF16867//PF13180//PF01369 PDZ domain (Also known as DHR or GLGF)//Dimethlysulfonioproprionate lyase//PDZ domain//Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086//GO:0005515//GO:0047869 ARF guanyl-nucleotide exchange factor activity//protein binding//dimethylpropiothetin dethiomethylase activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.45126 BF_2 480.43 98.99 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45128 BF_2 157.82 5.68 1449 642926052 XP_970129.2 648 6.8e-65 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P41034 207 3.8e-15 Alpha-tocopherol transfer protein OS=Rattus norvegicus GN=Ttpa PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45129 BF_2 225.21 1.21 8074 642938555 XP_008199840.1 3495 0.0e+00 PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum]>gi|642938557|ref|XP_008199841.1| PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum] 642938558 XR_511746.1 676 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X3, misc_RNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.6e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF08935//PF01312//PF01602//PF09258//PF00514 HEAT repeat//Viral protein VP4 subunit//FlhB HrpN YscU SpaS Family//Adaptin N terminal region//Glycosyl transferase family 64 domain//Armadillo/beta-catenin-like repeat GO:0015012//GO:0016192//GO:0006886//GO:0006024//GO:0009306 heparan sulfate proteoglycan biosynthetic process//vesicle-mediated transport//intracellular protein transport//glycosaminoglycan biosynthetic process//protein secretion GO:0005515 protein binding GO:0019030//GO:0016021//GO:0016020//GO:0030117 icosahedral viral capsid//integral component of membrane//membrane//membrane coat KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.45134 BF_2 43.51 0.36 5293 642912949 XP_008201320.1 755 9.8e-77 PREDICTED: uncharacterized protein LOC103315151 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18407 TDRD5 tudor domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18407 Q4R3G4 152 3.4e-08 RING finger protein 17 OS=Macaca fascicularis GN=RNF17 PE=2 SV=2 PF15151 Response gene to complement 32 protein family GO:0051726 regulation of cell cycle -- -- -- -- -- -- Cluster-8309.45135 BF_2 36.06 2.40 917 478263480 ENN81835.1 246 1.8e-18 hypothetical protein YQE_01774, partial [Dendroctonus ponderosae] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q7TSX5 140 1.4e-07 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Rattus norvegicus GN=Sgms1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45137 BF_2 31.93 0.35 4063 642913773 XP_008201155.1 4296 0.0e+00 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6H8H2 2020 6.4e-225 DENN domain-containing protein 4C OS=Mus musculus GN=Dennd4c PE=1 SV=1 PF04554 Extensin-like region GO:0042546//GO:0009664 cell wall biogenesis//plant-type cell wall organization GO:0005199 structural constituent of cell wall GO:0005618 cell wall KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.45140 BF_2 1421.07 4.72 12887 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 5.9e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0043248//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//proteasome assembly//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.45142 BF_2 196.63 0.65 12935 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 6.0e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0043248//GO:0005975 sucrose metabolic process//starch metabolic process//proteasome assembly//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.45144 BF_2 1006.33 578.49 356 429327037 AFZ78847.1 367 6.4e-33 putative cysteine-rich protein 1 [Coptotermes formosanus] -- -- -- -- -- -- -- -- -- P63255 292 1.3e-25 Cysteine-rich protein 1 OS=Rattus norvegicus GN=Crip1 PE=1 SV=2 PF03884//PF00412 Domain of unknown function (DUF329)//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.45146 BF_2 66.97 0.76 3981 189236323 XP_975243.2 2357 1.3e-262 PREDICTED: condensin complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YHY6 1231 1.9e-133 Condensin complex subunit 1 OS=Xenopus laevis GN=ncapd2 PE=1 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG0414 Chromosome condensation complex Condensin, subunit D2 Cluster-8309.45147 BF_2 58.37 1.86 1602 642929822 XP_975593.2 1060 1.3e-112 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.59798e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.3e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.45149 BF_2 212.89 6.01 1769 332374448 AEE62365.1 630 1.0e-62 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01934 MTHFS 5-formyltetrahydrofolate cyclo-ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01934 Q9D110 447 6.9e-43 5-formyltetrahydrofolate cyclo-ligase OS=Mus musculus GN=Mthfs PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3093 5-formyltetrahydrofolate cyclo-ligase Cluster-8309.45150 BF_2 86.63 2.65 1657 642929822 XP_975593.2 1036 8.0e-110 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.82956e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.4e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.45152 BF_2 79.63 1.07 3394 642916496 XP_008191066.1 2813 0.0e+00 PREDICTED: elongation factor Tu GTP-binding domain-containing protein 1 [Tribolium castaneum]>gi|270003614|gb|EFA00062.1| hypothetical protein TcasGA2_TC002875 [Tribolium castaneum] -- -- -- -- -- K14536 RIA1 ribosome assembly protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14536 Q7Z2Z2 1323 3.5e-144 Elongation factor Tu GTP-binding domain-containing protein 1 OS=Homo sapiens GN=EFTUD1 PE=1 SV=2 PF03764//PF03144//PF02961//PF08477 Elongation factor G, domain IV//Elongation factor Tu domain 2//Barrier to autointegration factor//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0003677//GO:0000166//GO:0005525 DNA binding//nucleotide binding//GTP binding -- -- KOG0467 Translation elongation factor 2/ribosome biogenesis protein RIA1 and related proteins Cluster-8309.45153 BF_2 53.75 1.70 1611 727098966 AIY54302.1 1001 8.8e-106 TATA-box-binding protein 1 [Colaphellus bowringi] -- -- -- -- -- K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 Q9YGV8 507 7.0e-50 TATA box-binding protein-like protein 1 OS=Gallus gallus GN=TBPL1 PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.45156 BF_2 157.63 0.99 6976 727098966 AIY54302.1 721 1.1e-72 TATA-box-binding protein 1 [Colaphellus bowringi] 762143181 XM_011456532.1 50 5.09786e-14 PREDICTED: Crassostrea gigas TATA box-binding protein-like protein 1 (LOC105347432), mRNA K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 Q9YGV8 339 9.1e-30 TATA box-binding protein-like protein 1 OS=Gallus gallus GN=TBPL1 PE=2 SV=1 PF00352 Transcription factor TFIID (or TATA-binding protein, TBP) GO:0006352 DNA-templated transcription, initiation GO:0003677 DNA binding -- -- KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.45157 BF_2 71.32 0.79 4042 871211803 XP_012946119.1 440 2.5e-40 PREDICTED: collagen alpha-1(I) chain-like [Aplysia californica] 170039347 XM_001847447.1 45 1.77184e-11 Culex quinquefasciatus collagen alpha 1(XVIII) chain, mRNA K08135 COL15A collagen, type XV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08135 P02453 358 3.3e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF10660//PF06482 Iron-containing outer mitochondrial membrane protein N-terminus//Collagenase NC10 and Endostatin GO:0007155 cell adhesion GO:0005198//GO:0051537 structural molecule activity//2 iron, 2 sulfur cluster binding GO:0043231//GO:0031012 intracellular membrane-bounded organelle//extracellular matrix -- -- Cluster-8309.45159 BF_2 133.73 2.26 2763 270000727 EEZ97174.1 449 1.5e-41 hypothetical protein TcasGA2_TC004361 [Tribolium castaneum] 752865554 XM_011270924.1 89 4.18728e-36 PREDICTED: Camponotus floridanus RNA-binding protein 1-like (LOC105259161), transcript variant X11, mRNA K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q02427 409 2.8e-38 RNA-binding protein 1 OS=Drosophila melanogaster GN=Rbp1 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-8309.45161 BF_2 163.55 8.20 1121 642911480 XP_008199442.1 1056 2.6e-112 PREDICTED: retinol dehydrogenase 13-like [Tribolium castaneum]>gi|270014891|gb|EFA11339.1| hypothetical protein TcasGA2_TC010879 [Tribolium castaneum] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 680 4.2e-70 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.45164 BF_2 232.50 0.98 10235 642935247 XP_008197929.1 5389 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 780 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1750 3.3e-193 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF00041//PF13895//PF13443//PF16656//PF05506 Fibronectin type III domain//Immunoglobulin domain//Cro/C1-type HTH DNA-binding domain//Purple acid Phosphatase, N-terminal domain//Domain of unknown function (DUF756) GO:0019497//GO:0009395//GO:0006771//GO:0016042 hexachlorocyclohexane metabolic process//phospholipid catabolic process//riboflavin metabolic process//lipid catabolic process GO:0005515//GO:0046872//GO:0004629//GO:0003993//GO:0043565 protein binding//metal ion binding//phospholipase C activity//acid phosphatase activity//sequence-specific DNA binding -- -- -- -- Cluster-8309.45168 BF_2 34.78 0.72 2322 478256208 ENN76402.1 688 2.5e-69 hypothetical protein YQE_07063, partial [Dendroctonus ponderosae] -- -- -- -- -- K19525 VPS13A_C vacuolar protein sorting-associated protein 13A/C http://www.genome.jp/dbget-bin/www_bget?ko:K19525 Q5H8C4 285 5.6e-24 Vacuolar protein sorting-associated protein 13A OS=Mus musculus GN=Vps13a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.45169 BF_2 143.28 3.35 2079 478258252 ENN78381.1 1023 3.2e-108 hypothetical protein YQE_05182, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 212 1.5e-15 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF00018//PF14604//PF00621 SH3 domain//Variant SH3 domain//RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG4240 Multidomain protein, contains SPEC repeats, PH, SH3, and separate rac-specific and rho-specific guanine nucleotide exchange factor domains Cluster-8309.45170 BF_2 404.29 1.35 12816 270013710 EFA10158.1 5454 0.0e+00 hypothetical protein TcasGA2_TC012347 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 5.2e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF03400//PF06553//PF13606//PF00023//PF00960//PF05510//PF00536 IS1 transposase//BNIP3//Ankyrin repeat//Ankyrin repeat//Neocarzinostatin family//Sarcoglycan alpha/epsilon//SAM domain (Sterile alpha motif) GO:0043065//GO:0006313//GO:0006952 positive regulation of apoptotic process//transposition, DNA-mediated//defense response GO:0004803//GO:0003677//GO:0005515 transposase activity//DNA binding//protein binding GO:0005740//GO:0016012//GO:0016021 mitochondrial envelope//sarcoglycan complex//integral component of membrane -- -- Cluster-8309.45172 BF_2 30.00 0.95 1610 -- -- -- -- -- 642911032 XM_008195295.1 170 2.26993e-81 PREDICTED: Tribolium castaneum small conductance calcium-activated potassium channel protein (LOC657962), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45175 BF_2 1110.74 4.23 11280 642918088 XP_008193953.1 2255 2.4e-250 PREDICTED: uncharacterized protein LOC103313170 isoform X2 [Tribolium castaneum] -- -- -- -- -- K17480 AATK, LMTK1 lemur tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17480 Q6ZMQ8 601 6.2e-60 Serine/threonine-protein kinase LMTK1 OS=Homo sapiens GN=AATK PE=1 SV=2 PF07402//PF14991//PF07714//PF00069 Human herpesvirus U26 protein//Protein melan-A//Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0042470//GO:0016021 melanosome//integral component of membrane -- -- Cluster-8309.45176 BF_2 1978.38 14.09 6161 189240296 XP_973610.2 2451 2.5e-273 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 P55156 752 1.0e-77 Microsomal triglyceride transfer protein large subunit (Fragment) OS=Bos taurus GN=MTTP PE=1 SV=1 PF09172//PF00019//PF01347 Domain of unknown function (DUF1943)//Transforming growth factor beta like domain//Lipoprotein amino terminal region GO:0006869//GO:0008283//GO:0040007//GO:0007165 lipid transport//cell proliferation//growth//signal transduction GO:0005319//GO:0008083 lipid transporter activity//growth factor activity -- -- KOG3900 Transforming growth factor beta, bone morphogenetic protein and related proteins Cluster-8309.45177 BF_2 23.29 0.63 1846 642934734 XP_967685.3 360 2.2e-31 PREDICTED: UDP-glucuronosyltransferase-like [Tribolium castaneum]>gi|270013464|gb|EFA09912.1| hypothetical protein TcasGA2_TC012063 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64676 131 3.2e-06 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Mus musculus GN=Ugt8 PE=2 SV=2 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.45180 BF_2 270.87 1.99 5969 642926198 XP_008194826.1 5231 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein castor homolog 1-like [Tribolium castaneum] 645021609 XM_008209379.1 386 0 PREDICTED: Nasonia vitripennis zinc finger protein castor homolog 1-like (LOC100116283), partial mRNA -- -- -- -- Q7M3M8 877 3.2e-92 Transcription factor castor OS=Drosophila melanogaster GN=cas PE=1 SV=2 PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.45184 BF_2 61.57 0.70 3966 642922116 XP_008193022.1 736 1.2e-74 PREDICTED: calcium channel flower isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 352 1.6e-31 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF03613//PF10233 PTS system mannose/fructose/sorbose family IID component//Uncharacterized conserved protein CG6151-P GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021 integral component of membrane KOG4085 Uncharacterized conserved protein Cluster-8309.45185 BF_2 786.48 10.95 3293 478258600 ENN78650.1 1780 8.5e-196 hypothetical protein YQE_04823, partial [Dendroctonus ponderosae]>gi|546676605|gb|ERL87577.1| hypothetical protein D910_04968 [Dendroctonus ponderosae] 696999013 XM_009567460.1 74 1.09023e-27 PREDICTED: Cuculus canorus regulatory solute carrier protein, family 1, member 1 (RSC1A1), mRNA K11885 DDI1 DNA damage-inducible protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11885 Q497D6 986 4.1e-105 Protein DDI1 homolog 2 OS=Xenopus tropicalis GN=ddi2 PE=2 SV=1 PF09668//PF00240 Aspartyl protease//Ubiquitin family GO:0006508 proteolysis GO:0004190//GO:0005515 aspartic-type endopeptidase activity//protein binding -- -- KOG0012 DNA damage inducible protein Cluster-8309.45188 BF_2 35.07 0.82 2068 642927514 XP_008195300.1 944 4.6e-99 PREDICTED: RNA-binding protein fusilli isoform X1 [Tribolium castaneum] -- -- -- -- -- K14947 ESRP1_2 epithelial splicing regulatory protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14947 Q9BJZ5 414 5.4e-39 RNA-binding protein fusilli OS=Drosophila melanogaster GN=fus PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1365 RNA-binding protein Fusilli, contains RRM domain Cluster-8309.45189 BF_2 2174.74 62.40 1745 91091630 XP_970163.1 1498 2.2e-163 PREDICTED: pyruvate dehydrogenase E1 component subunit beta, mitochondrial [Tribolium castaneum]>gi|270000896|gb|EEZ97343.1| hypothetical protein TcasGA2_TC011159 [Tribolium castaneum] 572261461 XM_006608952.1 211 3.98064e-104 PREDICTED: Apis dorsata pyruvate dehydrogenase E1 component subunit beta, mitochondrial-like (LOC102674287), transcript variant X3, mRNA K00162 PDHB, pdhB pyruvate dehydrogenase E1 component beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00162 O44451 1220 1.6e-132 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial OS=Caenorhabditis elegans GN=pdhb-1 PE=1 SV=2 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG0524 Pyruvate dehydrogenase E1, beta subunit Cluster-8309.45190 BF_2 153.86 2.66 2708 642927435 XP_008195272.1 827 2.2e-85 PREDICTED: UPF0183 protein CG7083 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSH9 574 2.0e-57 UPF0183 protein CG7083 OS=Drosophila melanogaster GN=CG7083 PE=2 SV=1 PF05094 Late expression factor 9 (LEF-9) GO:0019083 viral transcription -- -- -- -- KOG2819 Uncharacterized conserved protein Cluster-8309.45191 BF_2 875.65 11.27 3538 91085889 XP_967833.1 1816 6.1e-200 PREDICTED: UPF0183 protein CG7083 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VSH9 1366 3.8e-149 UPF0183 protein CG7083 OS=Drosophila melanogaster GN=CG7083 PE=2 SV=1 PF05094 Late expression factor 9 (LEF-9) GO:0019083 viral transcription -- -- -- -- KOG2819 Uncharacterized conserved protein Cluster-8309.45192 BF_2 304.57 6.11 2372 642916614 XP_008191899.1 1314 6.6e-142 PREDICTED: LOW QUALITY PROTEIN: suppressor of cytokine signaling 5 [Tribolium castaneum] -- -- -- -- -- K04697 SOCS4 suppressor of cytokine signaling 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04697 Q8WXH5 667 2.9e-68 Suppressor of cytokine signaling 4 OS=Homo sapiens GN=SOCS4 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.45193 BF_2 41.11 0.33 5471 270011060 EFA07508.1 2488 1.1e-277 hypothetical protein TcasGA2_TC009667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28666 738 3.9e-76 Murinoglobulin-2 OS=Mus musculus GN=Mug2 PE=2 SV=2 PF07678//PF07677//PF01835//PF00207//PF01483 A-macroglobulin complement component//A-macroglobulin receptor//MG2 domain//Alpha-2-macroglobulin family//Proprotein convertase P-domain GO:0006508 proteolysis GO:0004252//GO:0004866 serine-type endopeptidase activity//endopeptidase inhibitor activity GO:0005615//GO:0005576 extracellular space//extracellular region KOG1366 Alpha-macroglobulin Cluster-8309.45194 BF_2 371.44 1.49 10705 642914280 XP_008201619.1 1367 2.1e-147 PREDICTED: cyclic AMP-dependent transcription factor ATF-6 beta [Tribolium castaneum] 332375533 BT127946.1 81 4.58532e-31 Dendroctonus ponderosae clone DPO1025_H21 unknown mRNA K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q6GM78 703 8.7e-72 Isoaspartyl peptidase/L-asparaginase OS=Xenopus laevis GN=asrgl1 PE=2 SV=1 PF00170//PF00096//PF06005//PF06156//PF03604//PF12356//PF07716//PF07975//PF01166//PF03131//PF13912//PF01363//PF16866//PF04275//PF04977//PF14861//PF06467//PF07776//PF13465//PF03453//PF01112 bZIP transcription factor//Zinc finger, C2H2 type//Protein of unknown function (DUF904)//Protein of unknown function (DUF972)//DNA directed RNA polymerase, 7 kDa subunit//Protein of unknown function (DUF3643)//Basic region leucine zipper//TFIIH C1-like domain//TSC-22/dip/bun family//bZIP Maf transcription factor//C2H2-type zinc finger//FYVE zinc finger//PHD-finger//Phosphomevalonate kinase//Septum formation initiator//Plant antimicrobial peptide//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//MoeA N-terminal region (domain I and II)//Asparaginase GO:0016567//GO:0006144//GO:0032324//GO:0006351//GO:0043093//GO:0000917//GO:0006695//GO:0006206//GO:0032465//GO:0006281//GO:0050832//GO:0006915//GO:0006694//GO:0007049//GO:0006260//GO:0006355 protein ubiquitination//purine nucleobase metabolic process//molybdopterin cofactor biosynthetic process//transcription, DNA-templated//FtsZ-dependent cytokinesis//barrier septum assembly//cholesterol biosynthetic process//pyrimidine nucleobase metabolic process//regulation of cytokinesis//DNA repair//defense response to fungus//apoptotic process//steroid biosynthetic process//cell cycle//DNA replication//regulation of transcription, DNA-templated GO:0005515//GO:0004842//GO:0003677//GO:0046872//GO:0016787//GO:0003899//GO:0004631//GO:0003700//GO:0008270//GO:0043565 protein binding//ubiquitin-protein transferase activity//DNA binding//metal ion binding//hydrolase activity//DNA-directed RNA polymerase activity//phosphomevalonate kinase activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005730//GO:0005737 transcription factor complex//nucleus//nucleolus//cytoplasm KOG1592 Asparaginase Cluster-8309.45199 BF_2 113.60 1.73 3031 91080705 XP_975304.1 881 1.4e-91 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- K17352 TSPAN11 tetraspanin-11 http://www.genome.jp/dbget-bin/www_bget?ko:K17352 Q9QZA6 364 5.0e-33 CD151 antigen OS=Rattus norvegicus GN=Cd151 PE=1 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.4520 BF_2 34.22 1.96 1016 478254654 ENN74895.1 839 3.4e-87 hypothetical protein YQE_08473, partial [Dendroctonus ponderosae] 817052986 XM_012404120.1 175 2.35231e-84 PREDICTED: Athalia rosae SUMO-conjugating enzyme UBC9-B (LOC105688078), mRNA K10577 UBE2I, UBC9 ubiquitin-conjugating enzyme E2 I http://www.genome.jp/dbget-bin/www_bget?ko:K10577 Q9DDJ0 751 2.2e-78 SUMO-conjugating enzyme UBC9-B OS=Danio rerio GN=ube2ib PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0424 Ubiquitin-protein ligase Cluster-8309.45201 BF_2 16.00 0.43 1855 91077582 XP_973057.1 519 7.9e-50 PREDICTED: uncharacterized protein LOC661830 isoform X1 [Tribolium castaneum]>gi|270001568|gb|EEZ98015.1| hypothetical protein TcasGA2_TC000415 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45202 BF_2 696.18 15.11 2214 642914209 XP_008201591.1 790 3.6e-81 PREDICTED: uncharacterized protein LOC661830 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.45204 BF_2 96.33 0.74 5719 642928819 XP_008195574.1 1389 3.2e-150 PREDICTED: transcriptional repressor p66-alpha isoform X1 [Tribolium castaneum] 642928820 XM_008197353.1 64 6.89046e-22 PREDICTED: Tribolium castaneum transcriptional repressor p66-alpha (LOC656529), transcript variant X2, mRNA -- -- -- -- Q8WXI9 344 2.0e-30 Transcriptional repressor p66-beta OS=Homo sapiens GN=GATAD2B PE=1 SV=1 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667 transcription factor complex -- -- Cluster-8309.45205 BF_2 256.00 7.89 1645 91081763 XP_973188.1 796 5.3e-82 PREDICTED: UDP-glucuronosyltransferase 2B20 [Tribolium castaneum]>gi|270005052|gb|EFA01500.1| hypothetical protein TcasGA2_TC007056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 374 1.9e-34 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.45207 BF_2 113.92 0.55 8971 642917303 XP_008199243.1 6908 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X4 [Tribolium castaneum] 665815961 XM_008558446.1 643 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3679 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF06464//PF02710//PF02784//PF00501//PF01297 DMAP1-binding Domain//Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein//Pyridoxal-dependent decarboxylase, pyridoxal binding domain//AMP-binding enzyme//Zinc-uptake complex component A periplasmic GO:0030001//GO:0007165//GO:0008152//GO:0019064 metal ion transport//signal transduction//metabolic process//fusion of virus membrane with host plasma membrane GO:0016788//GO:0003824//GO:0008134//GO:0046789//GO:0046872 hydrolase activity, acting on ester bonds//catalytic activity//transcription factor binding//host cell surface receptor binding//metal ion binding GO:0005634//GO:0005667//GO:0019031//GO:0009986 nucleus//transcription factor complex//viral envelope//cell surface KOG3628 Predicted AMP-binding protein Cluster-8309.45211 BF_2 112.14 1.22 4133 642912871 XP_008201290.1 3785 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X7 [Tribolium castaneum] 642912870 XM_008203068.1 1166 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X7, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1287 6.4e-140 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00130//PF00788//PF00781//PF00076//PF07649//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//C1-like domain//PHD-finger GO:0007165//GO:0035556//GO:0055114 signal transduction//intracellular signal transduction//oxidation-reduction process GO:0016301//GO:0003676//GO:0047134//GO:0005515 kinase activity//nucleic acid binding//protein-disulfide reductase activity//protein binding -- -- KOG1169 Diacylglycerol kinase Cluster-8309.45212 BF_2 243.86 1.73 6180 642912869 XP_008201289.1 3556 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X6 [Tribolium castaneum] 642912868 XM_008203067.1 1382 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X6, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1296 8.7e-141 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF07649//PF00628//PF00781//PF00076//PF00609//PF00130//PF00788 C1-like domain//PHD-finger//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain GO:0046486//GO:0035556//GO:0055114//GO:0007205//GO:0009395//GO:0007165 glycerolipid metabolic process//intracellular signal transduction//oxidation-reduction process//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//signal transduction GO:0047134//GO:0003676//GO:0016301//GO:0005515//GO:0004143 protein-disulfide reductase activity//nucleic acid binding//kinase activity//protein binding//diacylglycerol kinase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.45214 BF_2 1254.92 17.16 3347 288869514 NP_001165864.1 2852 0.0e+00 extended synaptotagmin-like protein 2a [Tribolium castaneum]>gi|642923659|ref|XP_008193831.1| PREDICTED: extended synaptotagmin-like protein 2a isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M7N9 964 1.5e-102 Extended synaptotagmin-3 OS=Xenopus tropicalis GN=esyt3 PE=2 SV=1 PF17047//PF00168 Synaptotagmin-like mitochondrial-lipid-binding domain//C2 domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.45215 BF_2 496.29 19.83 1334 270008843 EFA05291.1 961 3.2e-101 hypothetical protein TcasGA2_TC015448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 260 2.5e-21 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45218 BF_2 2.44 2.91 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45222 BF_2 13.00 0.65 1122 332376577 AEE63428.1 277 5.5e-22 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q9Z0L8 149 1.6e-08 Gamma-glutamyl hydrolase OS=Mus musculus GN=Ggh PE=1 SV=2 PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.45225 BF_2 39.00 4.55 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45226 BF_2 500.19 14.64 1716 270297202 NP_001161902.1 988 3.0e-104 juvenile hormone epoxide hydrolase-like protein 5 precursor [Tribolium castaneum]>gi|269093690|dbj|BAI49690.1| juvenile hormone epoxide hydrolase-like protein 5 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q25489 845 4.8e-89 Juvenile hormone epoxide hydrolase OS=Manduca sexta PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.45227 BF_2 11.00 13.12 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45231 BF_2 55.24 0.54 4566 642934390 XP_008197640.1 2185 1.3e-242 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X2 [Tribolium castaneum] 462277993 APGK01058794.1 35 7.25738e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 813 6.5e-85 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.45233 BF_2 372.86 4.39 3838 642921365 XP_972788.2 3525 0.0e+00 PREDICTED: sorting nexin-25 [Tribolium castaneum] 766918141 XM_011498364.1 151 1.99825e-70 PREDICTED: Ceratosolen solmsi marchali RING-box protein 1A (LOC105361251), mRNA K17887 SNX25, MDM1 sorting nexin-25 http://www.genome.jp/dbget-bin/www_bget?ko:K17887 Q9H3E2 1310 1.3e-142 Sorting nexin-25 OS=Homo sapiens GN=SNX25 PE=1 SV=2 PF12861//PF12678//PF00097//PF00787//PF13639 Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//PX domain//Ring finger domain GO:0016567 protein ubiquitination GO:0005515//GO:0035091//GO:0046872//GO:0004842//GO:0008270 protein binding//phosphatidylinositol binding//metal ion binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex KOG2930 SCF ubiquitin ligase, Rbx1 component Cluster-8309.45235 BF_2 4.43 9.11 284 307196158 EFN77820.1 287 9.6e-24 hypothetical protein EAI_03910, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45236 BF_2 1.57 8.31 251 861603962 KMQ84139.1 217 1.1e-15 histone-lysine n-methyltransferase setmar [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45237 BF_2 271.36 3.48 3551 861603962 KMQ84139.1 355 1.6e-30 histone-lysine n-methyltransferase setmar [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45239 BF_2 14.64 0.31 2277 861603962 KMQ84139.1 349 5.0e-30 histone-lysine n-methyltransferase setmar [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45240 BF_2 1160.40 11.69 4439 642912959 XP_008201326.1 2864 0.0e+00 PREDICTED: programmed cell death 6-interacting protein [Tribolium castaneum]>gi|270001905|gb|EEZ98352.1| hypothetical protein TcasGA2_TC000807 [Tribolium castaneum] -- -- -- -- -- K12200 PDCD6IP, ALIX, RIM20 programmed cell death 6-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12200 Q9W6C5 1514 3.3e-166 Programmed cell death 6-interacting protein OS=Xenopus laevis GN=pdcd6ip PE=1 SV=1 PF04111//PF17082//PF13949 Autophagy protein Apg6//Spindle Pole Component 29//ALIX V-shaped domain binding to HIV GO:0030474//GO:0006914 spindle pole body duplication//autophagy GO:0005200//GO:0005515 structural constituent of cytoskeleton//protein binding GO:0005823//GO:0005856 central plaque of spindle pole body//cytoskeleton KOG2220 Predicted signal transduction protein Cluster-8309.45242 BF_2 927.21 18.04 2437 91076754 XP_973519.1 1295 1.1e-139 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P30638 168 2.2e-10 Putative transporter ZK637.1 OS=Caenorhabditis elegans GN=ZK637.1 PE=3 SV=5 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.45244 BF_2 109.12 1.78 2846 91076754 XP_973519.1 1049 4.3e-111 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7L1I2 155 8.1e-09 Synaptic vesicle glycoprotein 2B OS=Homo sapiens GN=SV2B PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.45245 BF_2 85.00 0.93 4098 861619777 KMQ87102.1 2897 0.0e+00 blastopia polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 776 1.1e-80 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00098//PF09668 Zinc knuckle//Aspartyl protease GO:0006508 proteolysis GO:0008270//GO:0003676//GO:0004190 zinc ion binding//nucleic acid binding//aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.45249 BF_2 659.85 9.04 3341 91076754 XP_973519.1 817 4.0e-84 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63564 313 4.5e-27 Synaptic vesicle glycoprotein 2B OS=Rattus norvegicus GN=Sv2b PE=1 SV=1 PF05631//PF07690//PF00083 Sugar-tranasporters, 12 TM//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0015689 transmembrane transport//molybdate ion transport GO:0022857//GO:0015098 transmembrane transporter activity//molybdate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.4525 BF_2 46.07 2.77 983 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45250 BF_2 101.59 1.35 3428 345489096 XP_001604048.2 2041 4.8e-226 PREDICTED: organic cation transporter protein-like [Nasonia vitripennis] 815793565 XM_012361984.1 64 4.1127e-22 PREDICTED: Linepithema humile uncharacterized LOC105669183 (LOC105669183), mRNA -- -- -- -- Q9VCA2 639 7.3e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.45251 BF_2 348.11 8.50 2001 91091236 XP_967765.1 731 2.2e-74 PREDICTED: golgin subfamily A member 7 [Tribolium castaneum]>gi|642936471|ref|XP_008198449.1| PREDICTED: golgin subfamily A member 7 [Tribolium castaneum]>gi|270014108|gb|EFA10556.1| hypothetical protein TcasGA2_TC012812 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D428 419 1.4e-39 Golgin subfamily A member 7B OS=Mus musculus GN=GOLGA7B PE=1 SV=1 PF03650 Uncharacterised protein family (UPF0041) GO:0006850 mitochondrial pyruvate transport -- -- GO:0005743 mitochondrial inner membrane KOG4069 Uncharacterized conserved protein Cluster-8309.45254 BF_2 86.60 2.42 1784 642931814 XP_008196744.1 920 2.4e-96 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 684 2.3e-70 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.45256 BF_2 38.80 0.98 1941 642917782 XP_008191284.1 687 2.7e-69 PREDICTED: calcium/calmodulin-dependent protein kinase type II alpha chain isoform X1 [Tribolium castaneum] -- -- -- -- -- K04515 CAMK2 calcium/calmodulin-dependent protein kinase (CaM kinase) II http://www.genome.jp/dbget-bin/www_bget?ko:K04515 Q00168 638 5.4e-65 Calcium/calmodulin-dependent protein kinase type II alpha chain OS=Drosophila melanogaster GN=CaMKII PE=1 SV=1 PF08332 Calcium/calmodulin dependent protein kinase II association domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005516//GO:0004683 calmodulin binding//calmodulin-dependent protein kinase activity -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.45259 BF_2 2673.43 30.76 3923 91087131 XP_975238.1 1903 5.5e-210 PREDICTED: trifunctional enzyme subunit beta, mitochondrial [Tribolium castaneum]>gi|270009593|gb|EFA06041.1| hypothetical protein TcasGA2_TC008872 [Tribolium castaneum] -- -- -- -- -- K07509 HADHB acetyl-CoA acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07509 O46629 1462 3.1e-160 Trifunctional enzyme subunit beta, mitochondrial OS=Bos taurus GN=HADHB PE=2 SV=1 PF08541//PF02803//PF08545//PF00108 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal//Thiolase, C-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0006633//GO:0008152//GO:0008610 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process//metabolic process//lipid biosynthetic process GO:0004315//GO:0016747 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005835 fatty acid synthase complex KOG1068 Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases Cluster-8309.4526 BF_2 6.32 0.42 924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45261 BF_2 1382.99 47.58 1503 332376360 AEE63320.1 1078 9.7e-115 unknown [Dendroctonus ponderosae] 821454901 XM_003756308.2 97 8.05256e-41 PREDICTED: Sarcophilus harrisii proteasome (prosome, macropain) subunit, alpha type, 3 (PSMA3), mRNA K02727 PSMA3 20S proteasome subunit alpha 7 http://www.genome.jp/dbget-bin/www_bget?ko:K02727 P25788 866 1.5e-91 Proteasome subunit alpha type-3 OS=Homo sapiens GN=PSMA3 PE=1 SV=2 PF00227//PF01896//PF10584 Proteasome subunit//Eukaryotic and archaeal DNA primase small subunit//Proteasome subunit A N-terminal signature GO:0006351//GO:0006511//GO:0006269//GO:0051603 transcription, DNA-templated//ubiquitin-dependent protein catabolic process//DNA replication, synthesis of RNA primer//proteolysis involved in cellular protein catabolic process GO:0003896//GO:0004175//GO:0004298 DNA primase activity//endopeptidase activity//threonine-type endopeptidase activity GO:0005657//GO:0005839//GO:0019773//GO:0005730 replication fork//proteasome core complex//proteasome core complex, alpha-subunit complex//nucleolus KOG0184 20S proteasome, regulatory subunit alpha type PSMA3/PRE10 Cluster-8309.45263 BF_2 176.06 2.02 3929 646720840 KDR22423.1 602 4.0e-59 hypothetical protein L798_01417, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q6P1L5 275 1.4e-22 Protein FAM117B OS=Homo sapiens GN=FAM117B PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45264 BF_2 257.87 7.02 1824 646720840 KDR22423.1 768 1.0e-78 hypothetical protein L798_01417, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q3U3E2 273 1.1e-22 Protein FAM117B OS=Mus musculus GN=Fam117b PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45266 BF_2 538.00 198.99 399 642911627 XP_968106.2 244 1.3e-18 PREDICTED: uncharacterized protein LOC656487 [Tribolium castaneum]>gi|270015130|gb|EFA11578.1| hypothetical protein TcasGA2_TC004750 [Tribolium castaneum] -- -- -- -- -- K03945 NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45269 BF_2 89.92 2.40 1853 820805548 AKG92765.1 895 2.0e-93 net [Leptinotarsa decemlineata] -- -- -- -- -- K00248 ACADS, bcd butyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00248 Q07417 308 9.5e-27 Short-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Mus musculus GN=Acads PE=1 SV=2 PF00010//PF00441 Helix-loop-helix DNA-binding domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016627//GO:0046983 oxidoreductase activity, acting on the CH-CH group of donors//protein dimerization activity -- -- KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.45272 BF_2 16.49 0.56 1509 546677533 ERL88352.1 606 5.3e-60 hypothetical protein D910_05739 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VH14 273 8.9e-23 Tissue inhibitor of metalloproteases OS=Drosophila melanogaster GN=Timp PE=2 SV=1 PF13673//PF00965 Acetyltransferase (GNAT) domain//Tissue inhibitor of metalloproteinase GO:0042967 acyl-carrier-protein biosynthetic process GO:0008191//GO:0008080 metalloendopeptidase inhibitor activity//N-acetyltransferase activity -- -- -- -- Cluster-8309.45274 BF_2 1371.61 19.28 3263 642938573 XP_969296.2 2189 3.1e-243 PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum]>gi|642938575|ref|XP_008199847.1| PREDICTED: acyl-CoA synthetase short-chain family member 3, mitochondrial [Tribolium castaneum] 195573452 XM_002104672.1 41 2.38836e-09 Drosophila simulans GD21091 (Dsim\GD21091), mRNA K01908 E6.2.1.17, prpE propionyl-CoA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01908 Q14DH7 1709 5.9e-189 Acyl-CoA synthetase short-chain family member 3, mitochondrial OS=Mus musculus GN=Acss3 PE=1 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1175 Acyl-CoA synthetase Cluster-8309.45275 BF_2 123.75 2.29 2545 546684308 ERL94013.1 1156 1.5e-123 hypothetical protein D910_11297 [Dendroctonus ponderosae] -- -- -- -- -- K15446 TRM13, CCDC76 tRNA:m4X modification enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K15446 Q9NUP7 616 2.5e-62 tRNA:m(4)X modification enzyme TRM13 homolog OS=Homo sapiens GN=TRMT13 PE=1 SV=2 PF11722//PF02077//PF05206 CCCH zinc finger in TRM13 protein//SURF4 family//Methyltransferase TRM13 GO:0008033 tRNA processing GO:0008168 methyltransferase activity GO:0016021 integral component of membrane KOG2811 Uncharacterized conserved protein Cluster-8309.45276 BF_2 41.52 0.31 5833 478257962 ENN78100.1 1149 2.2e-122 hypothetical protein YQE_05254, partial [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.51014e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 661 3.5e-67 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF06743//PF05733 FAST kinase-like protein, subdomain 1//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0004672//GO:0003723 protein kinase activity//RNA binding GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.45277 BF_2 1259.37 5.58 9725 642935247 XP_008197929.1 5274 0.0e+00 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] 642935246 XM_008199707.1 774 0 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 1668 1.0e-183 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13443//PF16656//PF00041//PF13895//PF05506 Cro/C1-type HTH DNA-binding domain//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain//Domain of unknown function (DUF756) GO:0016042//GO:0006771//GO:0019497//GO:0009395 lipid catabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//phospholipid catabolic process GO:0046872//GO:0004629//GO:0003993//GO:0043565//GO:0005515 metal ion binding//phospholipase C activity//acid phosphatase activity//sequence-specific DNA binding//protein binding -- -- -- -- Cluster-8309.45278 BF_2 390.64 11.96 1653 642920923 XP_008192617.1 786 7.8e-81 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q6GMC7 430 6.1e-41 Alcohol dehydrogenase [NADP(+)] OS=Xenopus laevis GN=akr1a1 PE=2 SV=1 PF03435 Saccharopine dehydrogenase NADP binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.45279 BF_2 263.84 2.88 4114 546681074 ERL91230.1 1528 1.8e-166 hypothetical protein D910_08566 [Dendroctonus ponderosae] -- -- -- -- -- K00911 ITPK 1D-myo-inositol-triphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00911 P42335 883 4.5e-93 Inositol-trisphosphate 3-kinase B OS=Rattus norvegicus GN=Itpkb PE=1 SV=3 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1621 1D-myo-inositol-triphosphate 3-kinase A Cluster-8309.4528 BF_2 5.00 0.54 674 672077319 XP_008768685.1 1014 1.1e-107 PREDICTED: spectrin beta chain, non-erythrocytic 1 isoform X4 [Rattus norvegicus] 672077318 XM_008770463.1 581 0 PREDICTED: Rattus norvegicus spectrin, beta, non-erythrocytic 1 (Sptbn1), transcript variant X5, mRNA K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q62261 1011 1.1e-108 Spectrin beta chain, non-erythrocytic 1 OS=Mus musculus GN=Sptbn1 PE=1 SV=2 PF06936//PF00435 Selenoprotein S (SelS)//Spectrin repeat GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0030176 integral component of endoplasmic reticulum membrane KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.45280 BF_2 692.47 5.17 5889 642915588 XP_008190677.1 7722 0.0e+00 PREDICTED: tyrosine-protein phosphatase Lar isoform X3 [Tribolium castaneum] 821135605 XM_012519131.1 232 2.88645e-115 PREDICTED: Dasypus novemcinctus protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant X15, mRNA K05695 PTPRF, LAR receptor-type tyrosine-protein phosphatase F http://www.genome.jp/dbget-bin/www_bget?ko:K05695 P16621 6820 0.0e+00 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF00102//PF16656//PF00041//PF09472//PF01108//PF00782 Protein-tyrosine phosphatase//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Tissue factor//Dual specificity phosphatase, catalytic domain GO:0006771//GO:0019497//GO:0046656//GO:0006570//GO:0006470//GO:0015948 riboflavin metabolic process//hexachlorocyclohexane metabolic process//folic acid biosynthetic process//tyrosine metabolic process//protein dephosphorylation//methanogenesis GO:0046872//GO:0003993//GO:0004725//GO:0005515//GO:0008138//GO:0030269 metal ion binding//acid phosphatase activity//protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//tetrahydromethanopterin S-methyltransferase activity GO:0016020 membrane -- -- Cluster-8309.45283 BF_2 1461.26 7.34 8614 642926407 XP_008191950.1 2727 3.4e-305 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 1.43715e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 3.1e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF10541//PF02376//PF00046//PF11593//PF02121//PF05920//PF03699 Nuclear envelope localisation domain//CUT domain//Homeobox domain//Mediator complex subunit 3 fungal//Phosphatidylinositol transfer protein//Homeobox KN domain//Uncharacterised protein family (UPF0182) GO:0006357//GO:0006355//GO:0006810 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//transport GO:0001104//GO:0003677 RNA polymerase II transcription cofactor activity//DNA binding GO:0005622//GO:0016592//GO:0016021 intracellular//mediator complex//integral component of membrane KOG3668 Phosphatidylinositol transfer protein Cluster-8309.45284 BF_2 3549.91 85.01 2034 546681357 ERL91467.1 785 1.2e-80 hypothetical protein D910_08797 [Dendroctonus ponderosae] -- -- -- -- -- K02265 COX5B cytochrome c oxidase subunit 5b http://www.genome.jp/dbget-bin/www_bget?ko:K02265 Q53HC9 387 7.3e-36 Protein TSSC1 OS=Homo sapiens GN=TSSC1 PE=1 SV=2 PF03121//PF01215 Herpesviridae UL52/UL70 DNA primase//Cytochrome c oxidase subunit Vb GO:0006260//GO:0006269//GO:0015992//GO:0006351//GO:0006123 DNA replication//DNA replication, synthesis of RNA primer//proton transport//transcription, DNA-templated//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0003896 cytochrome-c oxidase activity//DNA primase activity GO:0005740//GO:0005730//GO:0005657//GO:0045277 mitochondrial envelope//nucleolus//replication fork//respiratory chain complex IV KOG3352 Cytochrome c oxidase, subunit Vb/COX4 Cluster-8309.45286 BF_2 3327.85 20.60 7046 91085525 XP_972127.1 4732 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 isoform X1 [Tribolium castaneum]>gi|270008364|gb|EFA04812.1| hypothetical protein TcasGA2_TC014862 [Tribolium castaneum] 158287320 XM_309375.4 117 2.92855e-51 Anopheles gambiae str. PEST AGAP011271-PA (AgaP_AGAP011271) mRNA, partial cds K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 2155 2.4e-240 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF04346//PF00122 P5-type ATPase cation transporter//Ethanolamine utilisation protein, EutH//E1-E2 ATPase GO:0034229//GO:0006200//GO:0006812 ethanolamine transport//obsolete ATP catabolic process//cation transport GO:0005524//GO:0015662//GO:0034228//GO:0000166//GO:0016887//GO:0046872 ATP binding//ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism//ethanolamine transmembrane transporter activity//nucleotide binding//ATPase activity//metal ion binding GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.45288 BF_2 21.53 0.52 2016 270013489 EFA09937.1 184 6.0e-11 hypothetical protein TcasGA2_TC012090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45294 BF_2 35.49 0.50 3231 189237846 XP_974719.2 859 5.2e-89 PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|642924610|ref|XP_008194362.1| PREDICTED: BTB/POZ domain-containing protein 6 isoform X1 [Tribolium castaneum]>gi|270007960|gb|EFA04408.1| hypothetical protein TcasGA2_TC014707 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45295 BF_2 115.00 4.48 1362 676470177 XP_009058769.1 210 3.9e-14 hypothetical protein LOTGIDRAFT_164025 [Lottia gigantea]>gi|556101791|gb|ESO90443.1| hypothetical protein LOTGIDRAFT_164025 [Lottia gigantea] -- -- -- -- -- K02599 NOTCH Notch http://www.genome.jp/dbget-bin/www_bget?ko:K02599 P02535 132 1.8e-06 Keratin, type I cytoskeletal 10 OS=Mus musculus GN=Krt10 PE=1 SV=3 PF04952 Succinylglutamate desuccinylase / Aspartoacylase family GO:0008152 metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.45297 BF_2 199.11 2.64 3446 642916726 XP_008192366.1 1461 8.7e-159 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 141 4.1e-07 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.4530 BF_2 3.00 0.96 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00340 Interleukin-1 / 18 -- -- -- -- GO:0005615 extracellular space -- -- Cluster-8309.45300 BF_2 1091.77 14.49 3439 642913381 XP_008195471.1 796 1.1e-81 PREDICTED: double-strand-break repair protein rad21 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 284 1.1e-23 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF04824 Conserved region of Rad21 / Rec8 like protein -- -- -- -- GO:0000228 nuclear chromosome KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.45301 BF_2 492.23 6.50 3455 189234473 XP_001808764.1 796 1.1e-81 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] -- -- -- -- -- K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 282 1.8e-23 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF04824 Conserved region of Rad21 / Rec8 like protein -- -- -- -- GO:0000228 nuclear chromosome KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.45302 BF_2 499.65 7.22 3184 332372624 AEE61454.1 1753 1.1e-192 unknown [Dendroctonus ponderosae] 645007963 XM_008205563.1 265 7.02136e-134 PREDICTED: Nasonia vitripennis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (LOC100118240), transcript variant X4, mRNA K11648 SMARCB1, SNF5, INI1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11648 Q6DFM1 1331 3.9e-145 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xenopus tropicalis GN=smarcb1 PE=2 SV=1 PF08039//PF04855 Mitochondrial proteolipid//SNF5 / SMARCB1 / INI1 GO:0006338 chromatin remodeling -- -- GO:0005739//GO:0000228 mitochondrion//nuclear chromosome KOG1649 SWI-SNF chromatin remodeling complex, Snf5 subunit Cluster-8309.45303 BF_2 26.00 0.89 1512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45304 BF_2 3.00 0.90 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45306 BF_2 1058.75 9.73 4840 -- -- -- -- -- 642912444 XM_008202641.1 364 0 PREDICTED: Tribolium castaneum serum response factor (Srf), transcript variant X1, mRNA K04378 SRF serum response factor http://www.genome.jp/dbget-bin/www_bget?ko:K04378 Q3SXZ3 139 9.9e-07 Zinc finger protein 718 OS=Homo sapiens GN=ZNF718 PE=2 SV=1 PF13465//PF00096//PF00319//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//SRF-type transcription factor (DNA-binding and dimerisation domain)//C2H2-type zinc finger -- -- GO:0003677//GO:0046872//GO:0046983 DNA binding//metal ion binding//protein dimerization activity -- -- -- -- Cluster-8309.45307 BF_2 344.00 4.35 3592 617660946 XP_007537349.1 202 8.8e-13 PREDICTED: zinc finger protein 850-like [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- O75346 197 1.4e-13 Zinc finger protein 253 OS=Homo sapiens GN=ZNF253 PE=2 SV=2 PF02892//PF13912//PF00433//PF05191//PF13465//PF06689//PF00096//PF01155 BED zinc finger//C2H2-type zinc finger//Protein kinase C terminal domain//Adenylate kinase, active site lid//Zinc-finger double domain//ClpX C4-type zinc finger//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0016310//GO:0006144//GO:0046034//GO:0006468//GO:0009069//GO:0006464 phosphorylation//purine nucleobase metabolic process//ATP metabolic process//protein phosphorylation//serine family amino acid metabolic process//cellular protein modification process GO:0016151//GO:0046983//GO:0003677//GO:0005524//GO:0046872//GO:0004674//GO:0004017//GO:0008270 nickel cation binding//protein dimerization activity//DNA binding//ATP binding//metal ion binding//protein serine/threonine kinase activity//adenylate kinase activity//zinc ion binding -- -- -- -- Cluster-8309.45308 BF_2 147.78 1.82 3678 642918994 XP_008191690.1 1739 5.4e-191 PREDICTED: tyrosine-protein kinase Btk29A isoform X3 [Tribolium castaneum] 642918993 XM_008193468.1 324 1.29362e-166 PREDICTED: Tribolium castaneum tyrosine-protein kinase Btk29A (LOC663266), transcript variant X3, mRNA K07364 TEC tyrosine-protein kinase Tec http://www.genome.jp/dbget-bin/www_bget?ko:K07364 P08630 1518 9.3e-167 Tyrosine-protein kinase Btk29A OS=Drosophila melanogaster GN=Btk29A PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.45309 BF_2 328.14 4.29 3489 642918994 XP_008191690.1 2383 1.1e-265 PREDICTED: tyrosine-protein kinase Btk29A isoform X3 [Tribolium castaneum] 642918993 XM_008193468.1 455 0 PREDICTED: Tribolium castaneum tyrosine-protein kinase Btk29A (LOC663266), transcript variant X3, mRNA K07364 TEC tyrosine-protein kinase Tec http://www.genome.jp/dbget-bin/www_bget?ko:K07364 P08630 1986 4.8e-221 Tyrosine-protein kinase Btk29A OS=Drosophila melanogaster GN=Btk29A PE=2 SV=2 PF00069//PF14604//PF00018//PF07714 Protein kinase domain//Variant SH3 domain//SH3 domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding -- -- -- -- Cluster-8309.4531 BF_2 1.89 0.97 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45311 BF_2 468.12 4.83 4338 642918982 XP_008191684.1 4714 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.3512e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.45312 BF_2 542.50 6.11 4001 642932100 XP_008196854.1 1751 2.4e-192 PREDICTED: SPRY domain-containing SOCS box protein 1 isoform X2 [Tribolium castaneum] 642932099 XM_008198632.1 549 0 PREDICTED: Tribolium castaneum SPRY domain-containing SOCS box protein 1 (LOC664070), transcript variant X2, mRNA K10343 SPSB1_4, SSB1, SSB4 SPRY domain-containing SOCS box protein 1/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10343 A1Z6E0 1167 5.1e-126 Protein gustavus OS=Drosophila melanogaster GN=gus PE=1 SV=1 PF07525//PF00622 SOCS box//SPRY domain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3953 SOCS box protein SSB-1, contains SPRY domain Cluster-8309.45313 BF_2 236.28 4.08 2709 642928561 XP_008199958.1 1050 3.1e-111 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 O18635 743 5.1e-77 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0016705//GO:0005488 heme binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.45314 BF_2 75.86 2.23 1708 642928567 XP_008199961.1 576 1.8e-56 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 384 1.4e-35 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.45316 BF_2 1.00 4.80 254 705675810 XP_010116797.1 158 7.8e-09 PREDICTED: LOW QUALITY PROTEIN: ankyrin-1-like, partial [Chlamydotis macqueenii] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 P16157 148 4.6e-09 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45317 BF_2 166.97 2.23 3417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45318 BF_2 117.80 7.56 939 642925845 XP_008190534.1 669 1.6e-67 PREDICTED: mitogen-activated protein kinase-binding protein 1 isoform X3 [Tribolium castaneum] 642925848 XM_008192328.1 87 1.79872e-35 PREDICTED: Tribolium castaneum mitogen-activated protein kinase-binding protein 1 (LOC659789), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45319 BF_2 15.03 1.68 662 197116398 NP_001127706.1 295 2.7e-24 cytochrome P450 isoform 9F2 [Tribolium castaneum]>gi|270012795|gb|EFA09243.1| cytochrome P450 9Z5 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 213 3.5e-16 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067//PF03846 Cytochrome P450//Cell division inhibitor SulA GO:0009432//GO:0006118//GO:0051782//GO:0055114 SOS response//obsolete electron transport//negative regulation of cell division//oxidation-reduction process GO:0016705//GO:0004497//GO:0009055//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//monooxygenase activity//electron carrier activity//iron ion binding//heme binding GO:0009276 Gram-negative-bacterium-type cell wall -- -- Cluster-8309.45320 BF_2 468.83 20.80 1230 91077322 XP_974743.1 1310 1.0e-141 PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|642913792|ref|XP_008201162.1| PREDICTED: pre-mRNA-splicing factor 18 [Tribolium castaneum]>gi|270002090|gb|EEZ98537.1| hypothetical protein TcasGA2_TC001041 [Tribolium castaneum] 632985180 XM_007911344.1 103 3.02827e-44 PREDICTED: Callorhinchus milii pre-mRNA processing factor 18 (prpf18), mRNA K12817 PRPF18, PRP18 pre-mRNA-splicing factor 18 http://www.genome.jp/dbget-bin/www_bget?ko:K12817 Q8BM39 859 8.1e-91 Pre-mRNA-splicing factor 18 OS=Mus musculus GN=Prpf18 PE=2 SV=1 PF02840 Prp18 domain GO:0008380 RNA splicing -- -- GO:0005681 spliceosomal complex KOG2808 U5 snRNP-associated RNA splicing factor Cluster-8309.45322 BF_2 1455.72 27.38 2511 642930006 XP_008196062.1 318 2.2e-26 PREDICTED: vanin-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRR1 241 7.6e-19 Vanin-like protein 2 OS=Drosophila melanogaster GN=CG32751 PE=3 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.45324 BF_2 652.08 3.27 8638 642930272 XP_008196325.1 3813 0.0e+00 PREDICTED: AT-rich interactive domain-containing protein 4B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19195 ARID4B AT-rich interactive domain-containing protein 4B http://www.genome.jp/dbget-bin/www_bget?ko:K19195 Q4LE39 739 4.7e-76 AT-rich interactive domain-containing protein 4B OS=Homo sapiens GN=ARID4B PE=1 SV=2 PF01388 ARID/BRIGHT DNA binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.45329 BF_2 4.44 0.69 558 642932128 XP_975308.3 183 2.2e-11 PREDICTED: monocarboxylate transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01213//PF00684 Adenylate cyclase associated (CAP) N terminal//DnaJ central domain GO:0007010 cytoskeleton organization GO:0003779//GO:0031072//GO:0051082 actin binding//heat shock protein binding//unfolded protein binding -- -- -- -- Cluster-8309.45331 BF_2 444.60 5.35 3765 478249931 ENN70438.1 943 1.1e-98 hypothetical protein YQE_12942, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9IBG7 163 1.3e-09 Kielin/chordin-like protein OS=Xenopus laevis GN=kcp PE=2 SV=1 PF00093//PF00216 von Willebrand factor type C domain//Bacterial DNA-binding protein -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.45333 BF_2 154.83 0.87 7740 642935862 XP_008198202.1 2012 2.5e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 9.46976e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 4.0e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF00515//PF13374//PF13371//PF00400//PF13176//PF13414//PF13181//PF00638//PF02064 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//RanBP1 domain//MAS20 protein import receptor GO:0006605//GO:0006886//GO:0046907 protein targeting//intracellular protein transport//intracellular transport GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.45334 BF_2 66.69 0.37 7757 642935862 XP_008198202.1 2012 2.5e-222 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] 462302391 APGK01050245.1 46 9.49066e-12 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 1110 4.0e-119 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF13181//PF00638//PF02064//PF13414//PF13176//PF00400//PF00515//PF13374//PF13371 Tetratricopeptide repeat//RanBP1 domain//MAS20 protein import receptor//TPR repeat//Tetratricopeptide repeat//WD domain, G-beta repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006886//GO:0046907//GO:0006605 intracellular protein transport//intracellular transport//protein targeting GO:0005515 protein binding GO:0005742 mitochondrial outer membrane translocase complex KOG1125 TPR repeat-containing protein Cluster-8309.45336 BF_2 247.31 5.27 2252 642923358 XP_008193717.1 657 9.6e-66 PREDICTED: serine/threonine-protein phosphatase 1 regulatory subunit 10-like [Tribolium castaneum]>gi|270007046|gb|EFA03494.1| hypothetical protein TcasGA2_TC013494 [Tribolium castaneum] -- -- -- -- -- K17552 PPP1R10 protein phosphatase 1 regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K17552 Q6GLQ4 298 1.7e-25 Serine/threonine-protein phosphatase 1 regulatory subunit 10 OS=Xenopus laevis GN=ppp1r10 PE=2 SV=1 PF04006//PF00642//PF05297 Mpp10 protein//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Herpesvirus latent membrane protein 1 (LMP1) GO:0006364//GO:0019087//GO:0006351 rRNA processing//transformation of host cell by virus//transcription, DNA-templated GO:0008270//GO:0046872//GO:0003677 zinc ion binding//metal ion binding//DNA binding GO:0005732//GO:0034457//GO:0016021//GO:0005634 small nucleolar ribonucleoprotein complex//Mpp10 complex//integral component of membrane//nucleus -- -- Cluster-8309.45337 BF_2 323.02 4.28 3441 134131322 BAF49604.1 1073 8.5e-114 chitinase [Monochamus alternatus] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 489 1.8e-47 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00089//PF00704 Trypsin//Glycosyl hydrolases family 18 GO:0006508//GO:0005975 proteolysis//carbohydrate metabolic process GO:0004553//GO:0004252 hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type endopeptidase activity -- -- KOG2806 Chitinase Cluster-8309.45339 BF_2 26.45 0.45 2767 642933086 XP_008197254.1 848 8.4e-88 PREDICTED: tubulin polyglutamylase TTLL4-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K16601 TTLL4 tubulin polyglutamylase TTLL4 http://www.genome.jp/dbget-bin/www_bget?ko:K16601 Q14679 452 2.9e-43 Tubulin polyglutamylase TTLL4 OS=Homo sapiens GN=TTLL4 PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2157 Predicted tubulin-tyrosine ligase Cluster-8309.45341 BF_2 1428.98 26.43 2549 270015207 EFA11655.1 1074 4.8e-114 hypothetical protein TcasGA2_TC004080 [Tribolium castaneum] -- -- -- -- -- K07189 PPP1R3 protein phosphatase 1 regulatory subunit 3A/B/C/D/E http://www.genome.jp/dbget-bin/www_bget?ko:K07189 A6QNP3 340 2.6e-30 Protein phosphatase 1 regulatory subunit 3B OS=Bos taurus GN=PPP1R3B PE=2 SV=1 PF03370//PF16760 Carbohydrate/starch-binding module (family 21)//Starch/carbohydrate-binding module (family 53) -- -- GO:0005515//GO:2001070 protein binding//starch binding -- -- KOG3986 Protein phosphatase, regulatory subunit PPP1R3C/D Cluster-8309.45345 BF_2 763.80 14.51 2489 91094425 XP_969302.1 1958 1.5e-216 PREDICTED: host cell factor 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 Q9V4C8 625 2.2e-63 Host cell factor OS=Drosophila melanogaster GN=Hcf PE=1 SV=2 PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.45346 BF_2 730.33 9.22 3600 642939156 XP_008200359.1 1312 1.7e-141 PREDICTED: host cell factor 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14966 HCFC host cell factor http://www.genome.jp/dbget-bin/www_bget?ko:K14966 P51611 613 8.0e-62 Host cell factor 1 OS=Mesocricetus auratus GN=HCFC1 PE=1 SV=1 PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- KOG4152 Host cell transcription factor HCFC1 Cluster-8309.45349 BF_2 22.70 0.34 3083 642911939 XP_008199030.1 3213 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2 [Tribolium castaneum] 642911942 XM_008200810.1 525 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 Q9ULH1 1719 3.9e-190 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Homo sapiens GN=ASAP1 PE=1 SV=4 PF00023//PF13606//PF03114//PF01412//PF07043//PF08397 Ankyrin repeat//Ankyrin repeat//BAR domain//Putative GTPase activating protein for Arf//Protein of unknown function (DUF1328)//IRSp53/MIM homology domain GO:0007009 plasma membrane organization GO:0005096//GO:0005515 GTPase activator activity//protein binding GO:0005886//GO:0005737 plasma membrane//cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.45350 BF_2 883.31 7.25 5383 642911937 XP_008199029.1 3902 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 585 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1858 5.1e-206 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF03114//PF00018//PF00023//PF14604//PF07043//PF08397//PF13606//PF00465//PF01412 BAR domain//SH3 domain//Ankyrin repeat//Variant SH3 domain//Protein of unknown function (DUF1328)//IRSp53/MIM homology domain//Ankyrin repeat//Iron-containing alcohol dehydrogenase//Putative GTPase activating protein for Arf GO:0007009//GO:0055114 plasma membrane organization//oxidation-reduction process GO:0046872//GO:0005096//GO:0005515//GO:0016491 metal ion binding//GTPase activator activity//protein binding//oxidoreductase activity GO:0005737//GO:0005886 cytoplasm//plasma membrane -- -- Cluster-8309.45351 BF_2 109.24 0.36 12820 642926407 XP_008191950.1 4387 0.0e+00 PREDICTED: homeobox protein cut-like [Tribolium castaneum] 642930836 XM_963889.3 303 2.1419e-154 PREDICTED: Tribolium castaneum phosphatidylinositol transfer protein alpha isoform (LOC657428), transcript variant X1, mRNA K09313 CUTL homeobox protein cut-like http://www.genome.jp/dbget-bin/www_bget?ko:K09313 P10180 1051 4.6e-112 Homeobox protein cut OS=Drosophila melanogaster GN=ct PE=1 SV=1 PF00046//PF10541//PF02376//PF05920//PF03325//PF03699//PF02121 Homeobox domain//Nuclear envelope localisation domain//CUT domain//Homeobox KN domain//Herpesvirus polymerase accessory protein//Uncharacterised protein family (UPF0182)//Phosphatidylinositol transfer protein GO:0006260//GO:0006355//GO:0019079//GO:0006810 DNA replication//regulation of transcription, DNA-templated//viral genome replication//transport GO:0003677//GO:0030337 DNA binding//DNA polymerase processivity factor activity GO:0005622//GO:0016021//GO:0042575 intracellular//integral component of membrane//DNA polymerase complex KOG3668 Phosphatidylinositol transfer protein Cluster-8309.45352 BF_2 9.23 0.46 1131 270007579 EFA04027.1 461 2.6e-43 hypothetical protein TcasGA2_TC014256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45353 BF_2 302.55 3.24 4190 91077046 XP_968112.1 1016 4.2e-107 PREDICTED: ras-related C3 botulinum toxin substrate 1 [Tribolium castaneum]>gi|270002813|gb|EEZ99260.1| Mig-2-like protein [Tribolium castaneum] 746848885 XM_011056563.1 186 7.63327e-90 PREDICTED: Acromyrmex echinatior ras-related C3 botulinum toxin substrate 1 (LOC105146367), mRNA K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 P62999 770 5.8e-80 Ras-related C3 botulinum toxin substrate 1 OS=Canis familiaris GN=RAC1 PE=2 SV=1 PF08477//PF15894//PF05656//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//Inhibitor of glucose uptake transporter SgrT//Protein of unknown function (DUF805)//ADP-ribosylation factor family//Ras family GO:0007264//GO:0046325 small GTPase mediated signal transduction//negative regulation of glucose import GO:0005525 GTP binding GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular KOG0393 Ras-related small GTPase, Rho type Cluster-8309.45355 BF_2 1216.91 53.88 1232 642937410 XP_008198824.1 862 8.9e-90 PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|642937412|ref|XP_008198826.1| PREDICTED: putative 1-acyl-sn-glycerol-3-phosphate acyltransferase acl-2 [Tribolium castaneum]>gi|270000810|gb|EEZ97257.1| hypothetical protein TcasGA2_TC011057 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 380 2.8e-35 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0046486//GO:0008654//GO:0042967//GO:0008152 glycerolipid metabolic process//phospholipid biosynthetic process//acyl-carrier-protein biosynthetic process//metabolic process GO:0016746//GO:0003841 transferase activity, transferring acyl groups//1-acylglycerol-3-phosphate O-acyltransferase activity GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.45356 BF_2 40.38 0.92 2122 642931814 XP_008196744.1 1099 5.0e-117 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 797 2.2e-83 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.45357 BF_2 279.00 4.93 2655 642917087 XP_008191111.1 1264 4.7e-136 PREDICTED: probable ATP-dependent RNA helicase DDX20 [Tribolium castaneum]>gi|270004341|gb|EFA00789.1| hypothetical protein TcasGA2_TC003675 [Tribolium castaneum] -- -- -- -- -- K13131 DDX20, GEMIN3 ATP-dependent RNA helicase DDX20 http://www.genome.jp/dbget-bin/www_bget?ko:K13131 P0C218 932 6.0e-99 Probable ATP-dependent RNA helicase DDX20 OS=Danio rerio GN=ddx20 PE=3 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0004386//GO:0000166//GO:0005524//GO:0003677//GO:0016787//GO:0003676 helicase activity//nucleotide binding//ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- -- -- Cluster-8309.45360 BF_2 119.97 1.69 3258 531447909 AGT57849.1 1618 5.1e-177 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 1015 1.8e-108 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.45361 BF_2 811.50 4.51 7815 642936590 XP_008198497.1 1461 2.0e-158 PREDICTED: uncharacterized protein LOC103314369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12080 255 5.6e-20 Integrin alpha-PS2 OS=Drosophila melanogaster GN=if PE=1 SV=2 PF05375//PF15686 Pacifastin inhibitor (LCMII)//Lysine-rich CEACAM1 co-isolated protein family GO:0045766//GO:0043123//GO:0043066 positive regulation of angiogenesis//positive regulation of I-kappaB kinase/NF-kappaB signaling//negative regulation of apoptotic process GO:0030414 peptidase inhibitor activity -- -- KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.45362 BF_2 41.24 0.32 5696 642925023 XP_008194140.1 3709 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X4 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.96036e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.8e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.45363 BF_2 18.96 0.36 2498 642916810 XP_967695.2 1570 1.4e-171 PREDICTED: beta-parvin [Tribolium castaneum] -- -- -- -- -- K06275 PARV parvin http://www.genome.jp/dbget-bin/www_bget?ko:K06275 Q9HBI1 1086 7.9e-117 Beta-parvin OS=Homo sapiens GN=PARVB PE=1 SV=1 PF00307//PF00737 Calponin homology (CH) domain//Photosystem II 10 kDa phosphoprotein GO:0050821//GO:0015979 protein stabilization//photosynthesis GO:0042301//GO:0005515 phosphate ion binding//protein binding GO:0016020//GO:0009523 membrane//photosystem II KOG3631 Alpha-parvin and related focal adhesion proteins Cluster-8309.45365 BF_2 596.10 9.51 2908 642935358 XP_008197980.1 1397 1.9e-151 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E9QJ05 145 1.2e-07 Protein PET117 homolog, mitochondrial OS=Danio rerio GN=pet117 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45367 BF_2 932.00 25.53 1814 332376085 AEE63183.1 1974 1.5e-218 unknown [Dendroctonus ponderosae]>gi|478254813|gb|ENN75049.1| hypothetical protein YQE_08364, partial [Dendroctonus ponderosae]>gi|546676901|gb|ERL87825.1| hypothetical protein D910_05214 [Dendroctonus ponderosae] 642925677 XM_969308.2 332 2.25738e-171 PREDICTED: Tribolium castaneum ruvB-like 2 (LOC663252), mRNA K11338 RUVBL2, RVB2, INO80J RuvB-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11338 Q9DE27 1665 4.1e-184 RuvB-like 2 OS=Xenopus laevis GN=ruvbl2 PE=2 SV=1 PF06414//PF02367//PF02562//PF00910//PF06068//PF00158//PF03796//PF05496//PF07728//PF01695//PF00004 Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//RNA helicase//TIP49 C-terminus//Sigma-54 interaction domain//DnaB-like helicase C terminal domain//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//ATPase family associated with various cellular activities (AAA) GO:0006260//GO:0006355//GO:0006281//GO:0006310//GO:0002949 DNA replication//regulation of transcription, DNA-templated//DNA repair//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0016887//GO:0016301//GO:0005524//GO:0008134//GO:0003724//GO:0009378//GO:0003723//GO:0003678 ATPase activity//kinase activity//ATP binding//transcription factor binding//RNA helicase activity//four-way junction helicase activity//RNA binding//DNA helicase activity GO:0009379//GO:0005657//GO:0005667 Holliday junction helicase complex//replication fork//transcription factor complex KOG2680 DNA helicase TIP49, TBP-interacting protein Cluster-8309.45368 BF_2 219.62 0.76 12396 642913916 XP_008201212.1 3044 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X1 [Tribolium castaneum] 755870656 XM_005181954.2 137 3.93587e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 P51812 2107 1.6e-234 Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1 PF00069//PF06293//PF07714//PF00433 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Protein kinase C terminal domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.45370 BF_2 12.07 0.38 1628 642912660 XP_008200953.1 1394 2.4e-151 PREDICTED: aldose reductase-like [Tribolium castaneum]>gi|270002625|gb|EEZ99072.1| hypothetical protein TcasGA2_TC004950 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 758 5.5e-79 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.45371 BF_2 535.44 3.79 6204 91094947 XP_968721.1 2301 6.2e-256 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 1527 1.4e-167 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- KOG2432 Uncharacterized conserved protein Cluster-8309.45373 BF_2 146.02 0.51 12254 642931485 XP_008196605.1 917 3.7e-95 PREDICTED: insulin receptor substrate 1 isoform X9 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 1.5e-48 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF12814//PF02174 Meiotic cell cortex C-terminal pleckstrin homology//PTB domain (IRS-1 type) GO:0007165//GO:0032065 signal transduction//cortical protein anchoring GO:0005543//GO:0005515//GO:0005158 phospholipid binding//protein binding//insulin receptor binding GO:0005938//GO:0005899 cell cortex//insulin receptor complex -- -- Cluster-8309.45374 BF_2 1009.19 8.72 5130 642925748 XP_008201596.1 549 7.3e-53 PREDICTED: uncharacterized protein LOC103315223 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03967 Photosynthetic reaction centre, H-chain N-terminal region GO:0006118//GO:0019684 obsolete electron transport//photosynthesis, light reaction GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity GO:0030077 plasma membrane light-harvesting complex -- -- Cluster-8309.45375 BF_2 4.99 4.95 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45376 BF_2 233.58 1.70 6050 642938527 XP_008199828.1 2530 1.7e-282 PREDICTED: actin-related protein 8 [Tribolium castaneum] 642927958 XR_511541.1 53 9.49949e-16 PREDICTED: Tribolium castaneum transcriptional adapter 2B (LOC663682), transcript variant X2, misc_RNA K11673 ACTR8, ARP8, INO80N actin-related protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11673 Q0IEG8 1666 1.1e-183 Actin-related protein 8 OS=Aedes aegypti GN=Arp8 PE=3 SV=1 PF04433//PF00569//PF06723 SWIRM domain//Zinc finger, ZZ type//MreB/Mbl protein GO:0000902 cell morphogenesis GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0797 Actin-related protein Cluster-8309.45377 BF_2 89.06 0.67 5824 642938527 XP_008199828.1 2530 1.6e-282 PREDICTED: actin-related protein 8 [Tribolium castaneum] 642927958 XR_511541.1 53 9.14251e-16 PREDICTED: Tribolium castaneum transcriptional adapter 2B (LOC663682), transcript variant X2, misc_RNA K11673 ACTR8, ARP8, INO80N actin-related protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11673 Q0IEG8 1666 1.0e-183 Actin-related protein 8 OS=Aedes aegypti GN=Arp8 PE=3 SV=1 PF06723//PF00569//PF04433 MreB/Mbl protein//Zinc finger, ZZ type//SWIRM domain GO:0000902 cell morphogenesis GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0797 Actin-related protein Cluster-8309.45381 BF_2 91.10 1.25 3328 260795637 XP_002592811.1 669 5.8e-67 hypothetical protein BRAFLDRAFT_275668 [Branchiostoma floridae]>gi|229278035|gb|EEN48822.1| hypothetical protein BRAFLDRAFT_275668, partial [Branchiostoma floridae] 815905920 XM_012383378.1 159 6.17905e-75 PREDICTED: Bombus impatiens another transcription unit protein (LOC100742825), transcript variant X2, mRNA K15177 LEO1 RNA polymerase-associated protein LEO1 http://www.genome.jp/dbget-bin/www_bget?ko:K15177 Q05481 646 1.1e-65 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00346//PF16622//PF04004//PF13912//PF01363//PF00130//PF00096//PF07776 Zinc-finger double domain//Respiratory-chain NADH dehydrogenase, 49 Kd subunit//zinc-finger C2H2-type//Leo1-like protein//C2H2-type zinc finger//FYVE zinc finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0016570//GO:0035556//GO:0055114//GO:0006368 histone modification//intracellular signal transduction//oxidation-reduction process//transcription elongation from RNA polymerase II promoter GO:0008270//GO:0048038//GO:0046872//GO:0051287//GO:0016651 zinc ion binding//quinone binding//metal ion binding//NAD binding//oxidoreductase activity, acting on NAD(P)H GO:0016593//GO:0005634 Cdc73/Paf1 complex//nucleus -- -- Cluster-8309.45388 BF_2 686.14 3.77 7899 642937363 XP_008198806.1 4646 0.0e+00 PREDICTED: ATP-dependent helicase brm isoform X1 [Tribolium castaneum]>gi|642937365|ref|XP_008198807.1| PREDICTED: ATP-dependent helicase brm isoform X1 [Tribolium castaneum] 801398653 XM_012204404.1 479 0 PREDICTED: Atta cephalotes ATP-dependent helicase brm (LOC105623001), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 P25439 3883 0.0e+00 ATP-dependent helicase brm OS=Drosophila melanogaster GN=brm PE=1 SV=2 PF00176//PF04851//PF00270//PF13892//PF02935//PF14619//PF07533//PF00439//PF08880 SNF2 family N-terminal domain//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//DNA-binding domain//Cytochrome c oxidase subunit VIIc//Snf2-ATP coupling, chromatin remodelling complex//BRK domain//Bromodomain//QLQ GO:0006355//GO:0015992//GO:0006123 regulation of transcription, DNA-templated//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0042393//GO:0003676//GO:0004129//GO:0016817//GO:0005524//GO:0016787//GO:0003677//GO:0005515 histone binding//nucleic acid binding//cytochrome-c oxidase activity//hydrolase activity, acting on acid anhydrides//ATP binding//hydrolase activity//DNA binding//protein binding GO:0005634//GO:0045277 nucleus//respiratory chain complex IV KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.45389 BF_2 1656.17 12.85 5679 642915716 XP_008190773.1 4756 0.0e+00 PREDICTED: rho guanine nucleotide exchange factor 11 isoform X4 [Tribolium castaneum] 752876735 XM_011257478.1 63 2.46081e-21 PREDICTED: Camponotus floridanus rho guanine nucleotide exchange factor 12 (LOC105251006), transcript variant X6, mRNA K12331 ARHGEF11 Rho guanine nucleotide exchange factor 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12331 O15085 715 1.9e-73 Rho guanine nucleotide exchange factor 11 OS=Homo sapiens GN=ARHGEF11 PE=1 SV=1 PF09128//PF00130//PF13180//PF00595//PF00621 Regulator of G protein signalling-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGEF domain GO:0043087//GO:0035023//GO:0035556 regulation of GTPase activity//regulation of Rho protein signal transduction//intracellular signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding GO:0005737 cytoplasm KOG3520 Predicted guanine nucleotide exchange factor Cluster-8309.4539 BF_2 6.00 1.08 520 118083604 XP_416616.2 557 8.7e-55 PREDICTED: 60S ribosomal protein L24 [Gallus gallus]>gi|527266977|ref|XP_005151635.1| PREDICTED: 60S ribosomal protein L24 [Melopsittacus undulatus]>gi|729738889|ref|XP_010565634.1| PREDICTED: 60S ribosomal protein L24 [Haliaeetus leucocephalus]>gi|733872175|ref|XP_010718751.1| PREDICTED: 60S ribosomal protein L24 [Meleagris gallopavo]>gi|768340933|ref|XP_011582962.1| PREDICTED: 60S ribosomal protein L24 [Aquila chrysaetos canadensis] 694903177 XM_009446072.1 520 0 PREDICTED: Pan troglodytes ribosomal protein L24 (RPL24), mRNA K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q6Y263 533 2.2e-53 60S ribosomal protein L24 OS=Pagrus major GN=rpl24 PE=2 SV=1 PF07565 Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1722 60s ribosomal protein L24 Cluster-8309.45393 BF_2 281.69 1.74 7052 189239223 XP_973572.2 678 1.1e-67 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 1.31629e-74 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.45395 BF_2 139.09 0.70 8601 91082383 XP_968748.1 3389 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 751222477 XM_011166174.1 44 1.36191e-10 PREDICTED: Solenopsis invicta probable multidrug resistance-associated protein lethal(2)03659 (LOC105199199), mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2467 2.0e-276 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF00664//PF13304//PF00158//PF01926//PF01580//PF00931//PF00005//PF03266//PF03193//PF01637//PF02367//PF06414 Type II/IV secretion system protein//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//Sigma-54 interaction domain//50S ribosome-binding GTPase//FtsK/SpoIIIE family//NB-ARC domain//ABC transporter//NTPase//Protein of unknown function, DUF258//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0006810//GO:0055085//GO:0006355//GO:0002949 transport//transmembrane transport//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0003924//GO:0098519//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0000166//GO:0043531//GO:0003677//GO:0017111//GO:0005525 transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//nucleotide binding//ADP binding//DNA binding//nucleoside-triphosphatase activity//GTP binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.45396 BF_2 315.00 1.20 11302 642920962 XP_008192632.1 910 2.2e-94 PREDICTED: uncharacterized protein LOC103312136 [Tribolium castaneum]>gi|642920964|ref|XP_008192633.1| PREDICTED: uncharacterized protein LOC103312136 [Tribolium castaneum]>gi|270005145|gb|EFA01593.1| hypothetical protein TcasGA2_TC007157 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45397 BF_2 290.00 22.39 829 642924825 XP_967668.2 738 1.4e-75 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I922 290 5.2e-25 Regucalcin OS=Xenopus laevis GN=rgn PE=2 SV=1 PF01731 Arylesterase -- -- GO:0004064 arylesterase activity -- -- -- -- Cluster-8309.45398 BF_2 46.46 0.45 4654 91076340 XP_971067.1 1806 1.2e-198 PREDICTED: peroxisomal N(1)-acetyl-spermine/spermidine oxidase [Tribolium castaneum]>gi|270002541|gb|EEZ98988.1| hypothetical protein TcasGA2_TC004849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q865R1 602 1.9e-60 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus GN=PAOX PE=1 SV=3 PF01593//PF01134//PF06100//PF01494//PF07992//PF01266//PF00979 Flavin containing amine oxidoreductase//Glucose inhibited division protein A//MCRA family//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Reovirus outer capsid protein, Sigma 3 GO:0019058//GO:0055114//GO:0008033//GO:0006631 viral life cycle//oxidation-reduction process//tRNA processing//fatty acid metabolic process GO:0050151//GO:0005198//GO:0016491//GO:0071949//GO:0050660 oleate hydratase activity//structural molecule activity//oxidoreductase activity//FAD binding//flavin adenine dinucleotide binding -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.45399 BF_2 101.50 2.71 1852 642936637 XP_008198518.1 1491 1.5e-162 PREDICTED: zinc finger and BTB domain-containing protein 12 [Tribolium castaneum] 642936636 XM_008200296.1 101 5.95628e-43 PREDICTED: Tribolium castaneum zinc finger and BTB domain-containing protein 12 (LOC661906), mRNA -- -- -- -- Q01295 398 3.5e-37 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45400 BF_2 32.98 0.48 3171 167234455 NP_001107843.1 1160 6.4e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.9e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45401 BF_2 905.78 11.14 3688 568248634 ETN58473.1 1038 1.0e-109 Elongation of very long chain fatty acids protein [Anopheles darlingi] 642935170 XM_008201454.1 67 9.51723e-24 PREDICTED: Tribolium castaneum elongation of very long chain fatty acids protein AAEL008004 (LOC655397), mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 723 1.4e-74 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45402 BF_2 133.48 2.80 2284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45403 BF_2 83.58 1.07 3543 642926809 XP_008195022.1 416 1.3e-37 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PVG3 262 3.9e-21 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF01465//PF07776//PF04120//PF13465//PF01309//PF00096 GRIP domain//Zinc-finger associated domain (zf-AD)//Low affinity iron permease//Zinc-finger double domain//Equine arteritis virus small envelope glycoprotein//Zinc finger, C2H2 type GO:0000042//GO:0055085 protein targeting to Golgi//transmembrane transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0019031//GO:0005634 viral envelope//nucleus -- -- Cluster-8309.45404 BF_2 150.25 5.49 1433 91092260 XP_967199.1 755 2.6e-77 PREDICTED: uncharacterized protein C6orf136 [Tribolium castaneum]>gi|270001227|gb|EEZ97674.1| hypothetical protein TcasGA2_TC016219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SQH8 260 2.7e-21 Uncharacterized protein C6orf136 OS=Homo sapiens GN=C6orf136 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4457 Uncharacterized conserved protein Cluster-8309.45406 BF_2 528.59 2.27 10022 642917699 XP_008191335.1 2161 1.7e-239 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X5 [Tribolium castaneum] 817189456 XM_012414634.1 313 4.61897e-160 PREDICTED: Orussus abietinus mitogen-activated protein kinase kinase kinase kinase 5 (LOC105694191), transcript variant X5, mRNA K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q8IVH8 1310 3.3e-142 Mitogen-activated protein kinase kinase kinase kinase 3 OS=Homo sapiens GN=MAP4K3 PE=1 SV=1 PF07728//PF00069//PF07714//PF01926//PF00004//PF00437//PF00005//PF03193//PF03266//PF01637//PF00503//PF00910//PF01580 AAA domain (dynein-related subfamily)//Protein kinase domain//Protein tyrosine kinase//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//ABC transporter//Protein of unknown function, DUF258//NTPase//Archaeal ATPase//G-protein alpha subunit//RNA helicase//FtsK/SpoIIIE family GO:0006468//GO:0006810//GO:0007165//GO:0007186 protein phosphorylation//transport//signal transduction//G-protein coupled receptor signaling pathway GO:0003723//GO:0003677//GO:0003724//GO:0004672//GO:0005525//GO:0004871//GO:0003924//GO:0005524//GO:0098519//GO:0031683//GO:0000166//GO:0016887//GO:0019001 RNA binding//DNA binding//RNA helicase activity//protein kinase activity//GTP binding//signal transducer activity//GTPase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//G-protein beta/gamma-subunit complex binding//nucleotide binding//ATPase activity//guanyl nucleotide binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45407 BF_2 58.08 0.53 4833 642923482 XP_008193528.1 1562 2.4e-170 PREDICTED: hyccin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BYI3 417 5.7e-39 Hyccin OS=Homo sapiens GN=FAM126A PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.45408 BF_2 2063.00 16.64 5474 642913045 XP_008201364.1 6725 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35556 3609 0.0e+00 Fibrillin-2 OS=Homo sapiens GN=FBN2 PE=1 SV=3 PF09064//PF07645//PF00008 Thrombomodulin like fifth domain, EGF-like//Calcium-binding EGF domain//EGF-like domain GO:0007165 signal transduction GO:0005509//GO:0004888//GO:0005515 calcium ion binding//transmembrane signaling receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.45410 BF_2 30.66 1.12 1431 546673062 ERL84739.1 984 7.4e-104 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 453 1.1e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF03583//PF01764//PF00326//PF07859//PF02230 Secretory lipase//Lipase (class 3)//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase GO:0046486//GO:0016042//GO:0006508//GO:0006629//GO:0008152 glycerolipid metabolic process//lipid catabolic process//proteolysis//lipid metabolic process//metabolic process GO:0008236//GO:0004806//GO:0016787 serine-type peptidase activity//triglyceride lipase activity//hydrolase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.45411 BF_2 36.41 0.92 1941 546673062 ERL84739.1 984 1.0e-103 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 453 1.5e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF03583//PF11112//PF01764//PF02230//PF07859//PF00326 Secretory lipase//Pyocin activator protein PrtN//Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0016042//GO:0006355//GO:0046486//GO:0008152//GO:0006629 proteolysis//lipid catabolic process//regulation of transcription, DNA-templated//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0008236//GO:0016787//GO:0004806 serine-type peptidase activity//hydrolase activity//triglyceride lipase activity -- -- KOG1552 Predicted alpha/beta hydrolase Cluster-8309.45412 BF_2 6.29 1.14 518 478250471 ENN70966.1 337 2.8e-29 hypothetical protein YQE_12367, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AYT7 136 2.3e-07 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45415 BF_2 325.00 33.17 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45416 BF_2 3093.25 46.57 3066 91090560 XP_971544.1 1549 4.8e-169 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013348|gb|EFA09796.1| hypothetical protein TcasGA2_TC011938 [Tribolium castaneum] 751447204 XM_011179427.1 197 4.27386e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1022 2.5e-109 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151//PF02554 GNS1/SUR4 family//Carbon starvation protein CstA GO:0009267 cellular response to starvation -- -- GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.45421 BF_2 110.59 2.56 2096 91088863 XP_971818.1 142 4.7e-06 PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932389|ref|XP_008197091.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|642932391|ref|XP_008197092.1| PREDICTED: uncharacterized protein LOC660498 [Tribolium castaneum]>gi|270011591|gb|EFA08039.1| hypothetical protein TcasGA2_TC005632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45422 BF_2 28.00 1.75 956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45423 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45424 BF_2 11.00 5.26 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45429 BF_2 19.36 0.75 1373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4543 BF_2 11.00 0.62 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03323 Bacillus/Clostridium GerA spore germination protein GO:0009847 spore germination -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45430 BF_2 3.00 1.38 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45433 BF_2 200.49 2.30 3939 642927862 XP_008195429.1 2688 5.2e-301 PREDICTED: receptor-type tyrosine-protein phosphatase kappa isoform X2 [Tribolium castaneum]>gi|270009857|gb|EFA06305.1| hypothetical protein TcasGA2_TC009173 [Tribolium castaneum] 662183442 XM_008489250.1 153 1.58578e-71 PREDICTED: Diaphorina citri receptor-type tyrosine-protein phosphatase alpha (LOC103524239), mRNA K13297 PTPRT receptor-type tyrosine-protein phosphatase T http://www.genome.jp/dbget-bin/www_bget?ko:K13297 Q99M80 1006 2.3e-107 Receptor-type tyrosine-protein phosphatase T OS=Mus musculus GN=Ptprt PE=2 SV=2 PF00782//PF00641//PF00041//PF00102//PF07973 Dual specificity phosphatase, catalytic domain//Zn-finger in Ran binding protein and others//Fibronectin type III domain//Protein-tyrosine phosphatase//Threonyl and Alanyl tRNA synthetase second additional domain GO:0035335//GO:0043039//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//tRNA aminoacylation//protein dephosphorylation//tyrosine metabolic process GO:0008270//GO:0016876//GO:0005524//GO:0008138//GO:0005515//GO:0004725 zinc ion binding//ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.45434 BF_2 56.73 1.49 1884 642917693 XP_008191332.1 2257 2.4e-251 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 9.8e-120 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45435 BF_2 128.41 3.45 1845 642917699 XP_008191335.1 2220 4.5e-247 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X5 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 9.6e-120 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45436 BF_2 107.84 0.87 5467 642917699 XP_008191335.1 2220 1.3e-246 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 isoform X5 [Tribolium castaneum] -- -- -- -- -- K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q9Y4K4 1110 2.8e-119 Mitogen-activated protein kinase kinase kinase kinase 5 OS=Homo sapiens GN=MAP4K5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45439 BF_2 56.00 0.43 5787 642916405 XP_008191009.1 3474 0.0e+00 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.5e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF08397//PF00018//PF14604 IRSp53/MIM homology domain//SH3 domain//Variant SH3 domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.4544 BF_2 2.00 0.55 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45441 BF_2 606.00 12.86 2258 270001642 EEZ98089.1 550 2.5e-53 hypothetical protein TcasGA2_TC000502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8T3Y0 248 1.1e-19 Probable E3 ubiquitin-protein ligase sinah OS=Drosophila melanogaster GN=sinah PE=1 SV=2 PF03391//PF03145//PF02176 Nepovirus coat protein, central domain//Seven in absentia protein family//TRAF-type zinc finger GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0005634//GO:0019028 nucleus//viral capsid KOG3002 Zn finger protein Cluster-8309.45442 BF_2 2859.85 25.16 5042 91090308 XP_972041.1 1907 2.4e-210 PREDICTED: mitochondrial enolase superfamily member 1 [Tribolium castaneum]>gi|270013803|gb|EFA10251.1| hypothetical protein TcasGA2_TC012451 [Tribolium castaneum] 27633565 BX060284.1 95 3.55105e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC40CD04 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K18334 fucD L-fuconate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K18334 Q6INX4 1345 1.5e-146 Mitochondrial enolase superfamily member 1 OS=Xenopus laevis GN=enosf1 PE=2 SV=1 PF08116 PhTx neurotoxin family GO:0009405//GO:0009063 pathogenesis//cellular amino acid catabolic process GO:0003824 catalytic activity GO:0005576 extracellular region -- -- Cluster-8309.45443 BF_2 27.15 0.35 3498 642922662 XP_008193267.1 705 4.0e-71 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 492 8.3e-48 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016491//GO:0005506//GO:0020037//GO:0005488//GO:0016705 oxidoreductase activity//iron ion binding//heme binding//binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.45444 BF_2 47.15 0.47 4514 642910200 XP_008198377.1 2265 6.7e-252 PREDICTED: N-alpha-acetyltransferase 35, NatC auxiliary subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZHV2 1540 3.2e-169 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Gallus gallus GN=NAA35 PE=2 SV=1 PF02050//PF08287//PF01442//PF08336 Flagellar FliJ protein//Spc19//Apolipoprotein A1/A4/E domain//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0006525//GO:0018401//GO:0055114//GO:0008608//GO:0006869//GO:0071973//GO:0006560//GO:0006935//GO:0042157 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//oxidation-reduction process//attachment of spindle microtubules to kinetochore//lipid transport//bacterial-type flagellum-dependent cell motility//proline metabolic process//chemotaxis//lipoprotein metabolic process GO:0016702//GO:0004656//GO:0008289//GO:0003774 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//procollagen-proline 4-dioxygenase activity//lipid binding//motor activity GO:0005876//GO:0009288//GO:0042729//GO:0005783//GO:0005576//GO:0016020 spindle microtubule//bacterial-type flagellum//DASH complex//endoplasmic reticulum//extracellular region//membrane KOG2343 Glucose-repressible protein and related proteins Cluster-8309.45445 BF_2 131.17 2.54 2450 91079234 XP_970844.1 3509 0.0e+00 PREDICTED: TFIIH basal transcription factor complex helicase XPD subunit [Tribolium castaneum]>gi|270003570|gb|EFA00018.1| hypothetical protein TcasGA2_TC002825 [Tribolium castaneum] 572310025 XM_006620723.1 529 0 PREDICTED: Apis dorsata TFIIH basal transcription factor complex helicase XPD subunit-like (LOC102676342), mRNA K10844 ERCC2, XPD DNA excision repair protein ERCC-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10844 O08811 2758 1.0e-310 TFIIH basal transcription factor complex helicase XPD subunit OS=Mus musculus GN=Ercc2 PE=2 SV=2 PF06733//PF06777//PF13307//PF00580//PF00176//PF02562//PF04851//PF00270 DEAD_2//Helical and beta-bridge domain//Helicase C-terminal domain//UvrD/REP helicase N-terminal domain//SNF2 family N-terminal domain//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0006139//GO:0006289 nucleobase-containing compound metabolic process//nucleotide-excision repair GO:0005524//GO:0016787//GO:0003677//GO:0008026//GO:0004003//GO:0003676//GO:0016818 ATP binding//hydrolase activity//DNA binding//ATP-dependent helicase activity//ATP-dependent DNA helicase activity//nucleic acid binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005657//GO:0005634 replication fork//nucleus KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 Cluster-8309.45446 BF_2 1593.04 17.60 4073 189242134 XP_968235.2 1493 2.0e-162 PREDICTED: aspartyl/asparaginyl beta-hydroxylase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00476 ASPH aspartate beta-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00476 Q12797 1043 1.2e-111 Aspartyl/asparaginyl beta-hydroxylase OS=Homo sapiens GN=ASPH PE=1 SV=3 PF05118//PF00515//PF13414//PF04812//PF13176//PF13181//PF15339//PF13174 Aspartyl/Asparaginyl beta-hydroxylase//Tetratricopeptide repeat//TPR repeat//Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus//Tetratricopeptide repeat//Tetratricopeptide repeat//Acrosome formation-associated factor//Tetratricopeptide repeat GO:0045893//GO:0018193//GO:0006897//GO:0060478//GO:0007342 positive regulation of transcription, DNA-templated//peptidyl-amino acid modification//endocytosis//acrosomal vesicle exocytosis//fusion of sperm to egg plasma membrane GO:0005515 protein binding GO:0005886//GO:0005634 plasma membrane//nucleus KOG3696 Aspartyl beta-hydroxylase Cluster-8309.45448 BF_2 18.76 1.04 1042 270002439 EEZ98886.1 272 1.9e-21 hypothetical protein TcasGA2_TC004501 [Tribolium castaneum] -- -- -- -- -- K12824 TCERG1, CA150 transcription elongation regulator 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12824 O14776 135 6.2e-07 Transcription elongation regulator 1 OS=Homo sapiens GN=TCERG1 PE=1 SV=2 PF02862 DDHD domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.45450 BF_2 11.00 16.77 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45451 BF_2 363.72 3.30 4901 546675258 ERL86494.1 972 6.2e-102 hypothetical protein D910_03898 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45452 BF_2 457.87 3.65 5529 189239298 XP_971413.2 2145 6.7e-238 PREDICTED: protein lingerer isoform X3 [Tribolium castaneum] 642928928 XM_966320.3 252 2.0647e-126 PREDICTED: Tribolium castaneum protein lingerer (LOC660058), transcript variant X4, mRNA -- -- -- -- Q16VD3 579 1.1e-57 Protein lingerer OS=Aedes aegypti GN=lig PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45453 BF_2 701.37 16.10 2110 91078388 XP_974322.1 1200 9.8e-129 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|642915363|ref|XP_008190586.1| PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270003984|gb|EFA00432.1| hypothetical protein TcasGA2_TC003286 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q92051 566 1.3e-56 Carbonic anhydrase OS=Danio rerio GN=cahz PE=1 SV=2 -- -- GO:0006730//GO:0006807 one-carbon metabolic process//nitrogen compound metabolic process GO:0008270//GO:0004089//GO:0046872 zinc ion binding//carbonate dehydratase activity//metal ion binding -- -- -- -- Cluster-8309.45454 BF_2 58.39 0.57 4567 642919794 XP_008192070.1 4448 0.0e+00 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1086 1.4e-116 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.45455 BF_2 310.93 2.32 5900 642919794 XP_008192070.1 4571 0.0e+00 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1118 3.6e-120 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF00400//PF04053 WD domain, G-beta repeat//Coatomer WD associated region GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.45456 BF_2 236.48 2.96 3627 642910776 XP_008193405.1 2342 6.3e-261 PREDICTED: la-related protein 1 [Tribolium castaneum] 830109730 XM_012729993.1 95 2.54731e-39 PREDICTED: Condylura cristata La ribonucleoprotein domain family, member 1 (LARP1), mRNA K18757 LARP1 la-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18757 Q9VAW5 1170 2.1e-126 La-related protein 1 OS=Drosophila melanogaster GN=larp PE=1 SV=5 -- -- -- -- -- -- -- -- KOG2590 RNA-binding protein LARP/SRO9 and related La domain proteins Cluster-8309.45457 BF_2 677.85 9.05 3420 642936769 XP_008198572.1 840 8.8e-87 PREDICTED: general transcription factor IIF subunit 1 isoform X2 [Tribolium castaneum] 820846436 XM_012485722.1 154 3.82276e-72 PREDICTED: Apis florea general transcription factor IIF subunit 1-like (LOC100863803), mRNA K03138 TFIIF1, GTF2F1, TFG1 transcription initiation factor TFIIF subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03138 Q05913 679 1.7e-69 General transcription factor IIF subunit 1 OS=Drosophila melanogaster GN=TfIIFalpha PE=1 SV=3 PF08202//PF05793 Mis12-Mtw1 protein family//Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GO:0051301//GO:0032968//GO:0007059//GO:0006367 cell division//positive regulation of transcription elongation from RNA polymerase II promoter//chromosome segregation//transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005634//GO:0000444 nucleus//MIS12/MIND type complex KOG2393 Transcription initiation factor IIF, large subunit (RAP74) Cluster-8309.45460 BF_2 2144.08 20.14 4740 478257975 ENN78113.1 1310 3.8e-141 hypothetical protein YQE_05267, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 622 9.5e-63 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.45461 BF_2 1279.95 8.28 6757 546677006 ERL87922.1 2801 0.0e+00 hypothetical protein D910_05310 [Dendroctonus ponderosae] 642917861 XM_008193096.1 494 0 PREDICTED: Tribolium castaneum protein dopey-1 homolog (LOC656419), mRNA K02146 ATPeV0D, ATP6D V-type H+-transporting ATPase subunit d http://www.genome.jp/dbget-bin/www_bget?ko:K02146 Q25531 1736 9.0e-192 V-type proton ATPase subunit d OS=Manduca sexta PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2957 Vacuolar H+-ATPase V0 sector, subunit d Cluster-8309.45466 BF_2 228.34 3.41 3089 91078902 XP_973455.1 1013 6.9e-107 PREDICTED: syntaxin-7 [Tribolium castaneum] -- -- -- -- -- K08488 STX7 syntaxin 7 http://www.genome.jp/dbget-bin/www_bget?ko:K08488 Q3ZBT5 504 3.0e-49 Syntaxin-7 OS=Bos taurus GN=STX7 PE=2 SV=1 PF04632//PF02561//PF05531//PF00957//PF08597//PF00804//PF00015//PF05739 Fusaric acid resistance protein family//Flagellar protein FliS//Nucleopolyhedrovirus P10 protein//Synaptobrevin//Translation initiation factor eIF3 subunit//Syntaxin//Methyl-accepting chemotaxis protein (MCP) signalling domain//SNARE domain GO:0007165//GO:0006446//GO:0016192//GO:0006810 signal transduction//regulation of translational initiation//vesicle-mediated transport//transport GO:0004871//GO:0003743//GO:0005515 signal transducer activity//translation initiation factor activity//protein binding GO:0016020//GO:0005840//GO:0009288//GO:0005737//GO:0005852//GO:0005886//GO:0019028//GO:0016021 membrane//ribosome//bacterial-type flagellum//cytoplasm//eukaryotic translation initiation factor 3 complex//plasma membrane//viral capsid//integral component of membrane KOG0811 SNARE protein PEP12/VAM3/Syntaxin 7/Syntaxin 17 Cluster-8309.45468 BF_2 420.15 5.46 3504 91081981 XP_968444.1 1956 3.5e-216 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921927|ref|XP_008192949.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642921929|ref|XP_008192950.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270007370|gb|EFA03818.1| hypothetical protein TcasGA2_TC013933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 822 4.5e-86 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083//PF02568 Major Facilitator Superfamily//Sugar (and other) transporter//Thiamine biosynthesis protein (ThiI) GO:0055085//GO:0008033 transmembrane transport//tRNA processing GO:0022857//GO:0004810 transmembrane transporter activity//tRNA adenylyltransferase activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.4547 BF_2 3.00 0.40 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45472 BF_2 52.93 2.09 1346 642938577 XP_008199848.1 280 3.0e-22 PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938579|ref|XP_008199849.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938581|ref|XP_008199850.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938583|ref|XP_008199851.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|642938585|ref|XP_008199852.1| PREDICTED: plasma membrane calcium-transporting ATPase 2 isoform X1 [Tribolium castaneum]>gi|270015602|gb|EFA12050.1| hypothetical protein TcasGA2_TC001467 [Tribolium castaneum] 642938584 XM_008201630.1 147 1.15336e-68 PREDICTED: Tribolium castaneum plasma membrane calcium-transporting ATPase 1 (LOC656486), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF12424 Plasma membrane calcium transporter ATPase C terminal GO:0006816 calcium ion transport GO:0003824//GO:0005388 catalytic activity//calcium-transporting ATPase activity GO:0016529 sarcoplasmic reticulum -- -- Cluster-8309.45474 BF_2 130.19 5.45 1287 642912973 XP_008201334.1 1180 1.2e-126 PREDICTED: elongator complex protein 4 [Tribolium castaneum] -- -- -- -- -- K11375 ELP4 elongator complex protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11375 Q5XG58 511 1.9e-50 Elongator complex protein 4 OS=Xenopus laevis GN=elp4 PE=2 SV=1 PF05625 PAXNEB protein -- -- -- -- GO:0033588 Elongator holoenzyme complex KOG3949 RNA polymerase II elongator complex, subunit ELP4 Cluster-8309.45475 BF_2 181.11 0.60 12986 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 6.0e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005985//GO:0043248//GO:0005982//GO:0005975 sucrose metabolic process//proteasome assembly//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.45476 BF_2 808.48 7.63 4719 642930284 XP_008196328.1 1023 7.3e-108 PREDICTED: fanconi-associated nuclease 1 homolog isoform X1 [Tribolium castaneum]>gi|270010701|gb|EFA07149.1| hypothetical protein TcasGA2_TC010140 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LWH4 450 8.3e-43 Fanconi-associated nuclease 1 OS=Danio rerio GN=fan1 PE=2 SV=2 PF08774 VRR-NUC domain -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2143 Uncharacterized conserved protein Cluster-8309.45477 BF_2 7.00 1.46 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45480 BF_2 880.84 4.97 7704 817058126 XP_012250513.1 1919 1.5e-211 PREDICTED: beta-1,4-mannosyltransferase egh isoform X1 [Athalia rosae]>gi|817058128|ref|XP_012250514.1| PREDICTED: beta-1,4-mannosyltransferase egh isoform X1 [Athalia rosae] 642920158 XM_970403.3 374 0 PREDICTED: Tribolium castaneum beta-1,4-mannosyltransferase egh (LOC664396), mRNA K02359 EGH egghead protein (zeste-white 4 protein) http://www.genome.jp/dbget-bin/www_bget?ko:K02359 O01346 1850 6.2e-205 Beta-1,4-mannosyltransferase egh OS=Drosophila melanogaster GN=egh PE=2 SV=1 PF13506//PF00651 Glycosyl transferase family 21//BTB/POZ domain -- -- GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.45482 BF_2 223.87 1.19 8126 641658099 XP_008180596.1 937 1.2e-97 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 642920823 XM_008194352.1 69 1.62909e-24 PREDICTED: Tribolium castaneum transcription factor SPT20 homolog (LOC661459), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 886 4.0e-93 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF12090//PF13912//PF00412//PF04810//PF02892//PF12833//PF16622//PF13465 Zinc finger, C2H2 type//Spt20 family//C2H2-type zinc finger//LIM domain//Sec23/Sec24 zinc finger//BED zinc finger//Helix-turn-helix domain//zinc-finger C2H2-type//Zinc-finger double domain GO:0006355//GO:0006886//GO:0006888 regulation of transcription, DNA-templated//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0008270//GO:0003712//GO:0043565//GO:0046872//GO:0003700//GO:0003677 zinc ion binding//transcription cofactor activity//sequence-specific DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0030127//GO:0005667//GO:0000124 COPII vesicle coat//transcription factor complex//SAGA complex -- -- Cluster-8309.45484 BF_2 233.00 5.64 2015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05313 Poxvirus P21 membrane protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45486 BF_2 35.18 0.48 3382 642913496 XP_008201037.1 981 3.9e-103 PREDICTED: uncharacterized protein LOC100142275 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45487 BF_2 515.65 7.84 3038 189234485 XP_001811926.1 1069 2.2e-113 PREDICTED: uncharacterized protein LOC100142275 isoform X2 [Tribolium castaneum]>gi|270001729|gb|EEZ98176.1| hypothetical protein TcasGA2_TC000605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45489 BF_2 71.51 2.51 1481 642912091 XP_008200799.1 1091 3.0e-116 PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912093|ref|XP_008200800.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum]>gi|642912095|ref|XP_008200802.1| PREDICTED: ecdysone-induced protein 74EF isoform A isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45495 BF_2 25.64 1.21 1175 194754345 XP_001959456.1 143 2.0e-06 GF12046 [Drosophila ananassae]>gi|190620754|gb|EDV36278.1| GF12046 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04487//PF01155 CITED//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0006355 cellular protein modification process//regulation of transcription, DNA-templated GO:0016151 nickel cation binding GO:0005634 nucleus -- -- Cluster-8309.45496 BF_2 420.06 1.41 12774 642926088 XP_008194761.1 1377 1.8e-148 PREDICTED: uncharacterized protein LOC103313398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P08045 153 6.2e-08 Zinc finger protein Xfin OS=Xenopus laevis PE=1 SV=1 PF02990//PF15220//PF01222//PF09606//PF01214 Endomembrane protein 70//Hypoxia-inducible lipid droplet-associated//Ergosterol biosynthesis ERG4/ERG24 family//ARC105 or Med15 subunit of Mediator complex non-fungal//Casein kinase II regulatory subunit GO:0045859//GO:0010884//GO:0001819//GO:0008284//GO:0006357 regulation of protein kinase activity//positive regulation of lipid storage//positive regulation of cytokine production//positive regulation of cell proliferation//regulation of transcription from RNA polymerase II promoter GO:0001104//GO:0019887 RNA polymerase II transcription cofactor activity//protein kinase regulator activity GO:0016021//GO:0016592//GO:0005956//GO:0016020 integral component of membrane//mediator complex//protein kinase CK2 complex//membrane -- -- Cluster-8309.45497 BF_2 4.00 0.88 477 270008985 EFA05433.1 241 3.5e-18 hypothetical protein TcasGA2_TC015610 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09606 ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.45498 BF_2 7.00 15.50 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45500 BF_2 213.49 2.73 3564 189241728 XP_966529.2 1790 6.3e-197 PREDICTED: polycomb protein Scm [Tribolium castaneum] 817209209 XM_012425227.1 101 1.15615e-42 PREDICTED: Orussus abietinus polycomb protein Scm-like (LOC105699853), transcript variant X3, mRNA K11461 SCMH1 polycomb protein SCMH1 http://www.genome.jp/dbget-bin/www_bget?ko:K11461 Q9VHA0 1356 5.5e-148 Polycomb protein Scm OS=Drosophila melanogaster GN=Scm PE=1 SV=2 PF05495//PF02820//PF02069//PF03145//PF06467 CHY zinc finger//mbt repeat//Prokaryotic metallothionein//Seven in absentia protein family//MYM-type Zinc finger with FCS sequence motif GO:0006511//GO:0006355//GO:0007275 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated//multicellular organismal development GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.45502 BF_2 57.92 0.50 5090 642925869 XP_008190626.1 2127 7.6e-236 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 1060 1.7e-113 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF01421//PF01562//PF00413 Reprolysin (M12B) family zinc metalloprotease//Reprolysin family propeptide//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.45505 BF_2 24.04 0.58 2032 642916102 XP_971729.2 1730 3.3e-190 PREDICTED: DDB1- and CUL4-associated factor 11 [Tribolium castaneum] -- -- -- -- -- K11801 WDR23 WD repeat-containing protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K11801 Q5R7H5 1196 1.1e-129 DDB1- and CUL4-associated factor 11 OS=Pongo abelii GN=DCAF11 PE=2 SV=2 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0266 WD40 repeat-containing protein Cluster-8309.45506 BF_2 2283.53 10.19 9663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45509 BF_2 336.96 2.02 7266 642915546 XP_008190660.1 7945 0.0e+00 PREDICTED: serine/threonine-protein kinase SMG1 [Tribolium castaneum] -- -- -- -- -- K08873 SMG1 PI-3-kinase-related kinase SMG-1 http://www.genome.jp/dbget-bin/www_bget?ko:K08873 Q8BKX6 1869 3.7e-207 Serine/threonine-protein kinase SMG1 OS=Mus musculus GN=Smg1 PE=1 SV=3 PF15785//PF00454//PF08771 Serine/threonine-protein kinase smg-1//Phosphatidylinositol 3- and 4-kinase//Rapamycin binding domain GO:0009069//GO:0000184//GO:0016310 serine family amino acid metabolic process//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//phosphorylation GO:0008144//GO:0004674//GO:0016773 drug binding//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0891 DNA-dependent protein kinase Cluster-8309.45512 BF_2 420.00 3.91 4786 642915546 XP_008190660.1 3375 0.0e+00 PREDICTED: serine/threonine-protein kinase SMG1 [Tribolium castaneum] 642915545 XM_008192438.1 117 1.9853e-51 PREDICTED: Tribolium castaneum serine/threonine-protein kinase SMG1 (LOC658025), mRNA K08873 SMG1 PI-3-kinase-related kinase SMG-1 http://www.genome.jp/dbget-bin/www_bget?ko:K08873 Q8BKX6 999 1.8e-106 Serine/threonine-protein kinase SMG1 OS=Mus musculus GN=Smg1 PE=1 SV=3 PF05773//PF02260 RWD domain//FATC domain -- -- GO:0005515 protein binding -- -- KOG0891 DNA-dependent protein kinase Cluster-8309.45513 BF_2 75.04 0.45 7214 642915546 XP_008190660.1 7945 0.0e+00 PREDICTED: serine/threonine-protein kinase SMG1 [Tribolium castaneum] -- -- -- -- -- K08873 SMG1 PI-3-kinase-related kinase SMG-1 http://www.genome.jp/dbget-bin/www_bget?ko:K08873 Q8BKX6 1869 3.7e-207 Serine/threonine-protein kinase SMG1 OS=Mus musculus GN=Smg1 PE=1 SV=3 PF08771//PF15785//PF00454 Rapamycin binding domain//Serine/threonine-protein kinase smg-1//Phosphatidylinositol 3- and 4-kinase GO:0009069//GO:0016310//GO:0000184 serine family amino acid metabolic process//phosphorylation//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0016773//GO:0008144//GO:0004674 phosphotransferase activity, alcohol group as acceptor//drug binding//protein serine/threonine kinase activity -- -- KOG0891 DNA-dependent protein kinase Cluster-8309.45516 BF_2 1990.40 14.11 6187 91087059 XP_974768.1 2503 2.3e-279 PREDICTED: angiotensin-converting enzyme-like [Tribolium castaneum] 705688348 XM_010123009.1 125 9.18128e-56 PREDICTED: Chlamydotis macqueenii SMAD family member 2 (SMAD2), transcript variant X2, mRNA K04500 SMAD2_3 mothers against decapentaplegic homolog 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K04500 P84022 1609 4.4e-177 Mothers against decapentaplegic homolog 3 OS=Homo sapiens GN=SMAD3 PE=1 SV=1 PF01401//PF10401//PF03166//PF03165 Angiotensin-converting enzyme//Interferon-regulatory factor 3//MH2 domain//MH1 domain GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0008241//GO:0008237//GO:0003700 peptidyl-dipeptidase activity//metallopeptidase activity//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005622//GO:0016020 transcription factor complex//intracellular//membrane -- -- Cluster-8309.45517 BF_2 21.00 5.84 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45524 BF_2 516.76 8.04 2977 91094931 XP_970563.1 2741 2.8e-307 PREDICTED: bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase [Tribolium castaneum]>gi|270016688|gb|EFA13134.1| hypothetical protein TcasGA2_TC010318 [Tribolium castaneum] 572264375 XM_006610309.1 75 2.73716e-28 PREDICTED: Apis dorsata bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2-like (LOC102670740), transcript variant X2, mRNA K13811 PAPSS 3'-phosphoadenosine 5'-phosphosulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13811 Q27128 2136 1.6e-238 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase OS=Urechis caupo PE=2 SV=1 PF01583//PF01747 Adenylylsulphate kinase//ATP-sulfurylase GO:0006790//GO:0000103//GO:0006144 sulfur compound metabolic process//sulfate assimilation//purine nucleobase metabolic process GO:0004781//GO:0005524//GO:0004020 sulfate adenylyltransferase (ATP) activity//ATP binding//adenylylsulfate kinase activity -- -- KOG4238 Bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase Cluster-8309.45533 BF_2 475.98 18.12 1386 642931051 XP_008196192.1 746 2.8e-76 PREDICTED: myeloid leukemia factor isoform X4 [Tribolium castaneum]>gi|270012061|gb|EFA08509.1| hypothetical protein TcasGA2_TC006162 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NKV0 358 1.1e-32 Myeloid leukemia factor OS=Drosophila melanogaster GN=Mlf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45534 BF_2 114.39 2.04 2636 827551061 XP_012547435.1 489 3.4e-46 PREDICTED: cAMP-dependent protein kinase catalytic subunit alpha-like [Bombyx mori] -- -- -- -- -- K04345 PKA protein kinase A http://www.genome.jp/dbget-bin/www_bget?ko:K04345 P17612 484 5.3e-47 cAMP-dependent protein kinase catalytic subunit alpha OS=Homo sapiens GN=PRKACA PE=1 SV=2 PF00069//PF07714//PF16035 Protein kinase domain//Protein tyrosine kinase//Chalcone isomerase like GO:0006468 protein phosphorylation GO:0016872//GO:0004672//GO:0005524 intramolecular lyase activity//protein kinase activity//ATP binding -- -- KOG0616 cAMP-dependent protein kinase catalytic subunit (PKA) Cluster-8309.45535 BF_2 96.23 0.35 11627 642936312 XP_008198391.1 8183 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 1.00468e-77 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3630 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF03822//PF14604//PF00018//PF07651//PF01608 NAF domain//Variant SH3 domain//SH3 domain//ANTH domain//I/LWEQ domain GO:0007165 signal transduction GO:0003779//GO:0005515//GO:0005543 actin binding//protein binding//phospholipid binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.45536 BF_2 984.71 7.23 5983 646700010 KDR10365.1 926 1.6e-96 Angiopoietin-related protein 1 [Zootermopsis nevadensis] 578359011 KJ186851.1 49 1.57189e-13 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- Q9UKU9 544 1.3e-53 Angiopoietin-related protein 2 OS=Homo sapiens GN=ANGPTL2 PE=2 SV=1 PF04513//PF06009//PF04136//PF01607 Baculovirus polyhedron envelope protein, PEP, C terminus//Laminin Domain II//Sec34-like family//Chitin binding Peritrophin-A domain GO:0006886//GO:0006030//GO:0007155 intracellular protein transport//chitin metabolic process//cell adhesion GO:0005198//GO:0008061 structural molecule activity//chitin binding GO:0019031//GO:0019028//GO:0005576//GO:0005801//GO:0016020 viral envelope//viral capsid//extracellular region//cis-Golgi network//membrane -- -- Cluster-8309.45537 BF_2 1051.02 53.37 1111 546674232 ERL85660.1 317 1.3e-26 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45538 BF_2 24.16 1.57 929 642920389 XP_008192326.1 190 5.6e-12 PREDICTED: probable H/ACA ribonucleoprotein complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45539 BF_2 689.01 5.62 5416 642925019 XP_008194138.1 3889 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X2 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.61604e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.6e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.45540 BF_2 9.00 0.68 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45541 BF_2 505.69 15.23 1676 91092034 XP_969657.1 1306 4.0e-141 PREDICTED: proton-coupled amino acid transporter 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 499 6.1e-49 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.45543 BF_2 323.00 4.37 3377 642933143 XP_008197274.1 3049 0.0e+00 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] 642933142 XM_008199052.1 70 1.8714e-25 PREDICTED: Tribolium castaneum UPF0378 protein KIAA0100 (LOC662561), mRNA -- -- -- -- Q5SYL3 445 2.3e-42 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1910 Uncharacterized conserved protein Cluster-8309.45544 BF_2 2839.32 34.26 3754 642934158 XP_968636.2 1148 1.9e-122 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 680 1.4e-69 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01805//PF01151 Surp module//GNS1/SUR4 family GO:0006396 RNA processing GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.45548 BF_2 707.77 6.05 5181 91091282 XP_966431.1 1870 4.9e-206 PREDICTED: rab5 GDP/GTP exchange factor isoform X1 [Tribolium castaneum]>gi|270013085|gb|EFA09533.1| hypothetical protein TcasGA2_TC011637 [Tribolium castaneum] 642936530 XM_961338.3 239 3.25906e-119 PREDICTED: Tribolium castaneum rab5 GDP/GTP exchange factor (LOC658256), transcript variant X1, mRNA -- -- -- -- O18973 696 2.7e-71 Rab5 GDP/GTP exchange factor OS=Bos taurus GN=RABGEF1 PE=1 SV=1 PF01754 A20-like zinc finger -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.45549 BF_2 11.00 0.44 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45551 BF_2 13.23 0.35 1882 642935114 XP_008197893.1 483 1.2e-45 PREDICTED: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1 isoform X2 [Tribolium castaneum] 573874497 XM_006625570.1 40 4.91813e-09 PREDICTED: Lepisosteus oculatus 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-like (LOC102694917), mRNA K01103 PFKFB3 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3  http://www.genome.jp/dbget-bin/www_bget?ko:K01103 Q91348 211 1.7e-15 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase OS=Gallus gallus PE=2 SV=2 PF07294//PF03851//PF01591 Fibroin P25//UV-endonuclease UvdE//6-phosphofructo-2-kinase GO:0006000//GO:0006013//GO:0006289//GO:0009411 fructose metabolic process//mannose metabolic process//nucleotide-excision repair//response to UV GO:0003873//GO:0005198//GO:0004519//GO:0005524 6-phosphofructo-2-kinase activity//structural molecule activity//endonuclease activity//ATP binding GO:0005576 extracellular region KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.45552 BF_2 520.41 3.83 5965 642937896 XP_008200347.1 2573 1.7e-287 PREDICTED: protein vav isoform X1 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1473 2.5e-161 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00130//PF00307//PF00018//PF14604//PF00621 Phorbol esters/diacylglycerol binding domain (C1 domain)//Calponin homology (CH) domain//SH3 domain//Variant SH3 domain//RhoGEF domain GO:0035556//GO:0043087//GO:0035023 intracellular signal transduction//regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.45554 BF_2 472.52 4.91 4310 478251097 ENN71573.1 1390 1.9e-150 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 209 6.7e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402//PF00036 Man1-Src1p-C-terminal domain//EF hand -- -- GO:0005509 calcium ion binding GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.45555 BF_2 297.37 18.43 962 270002027 EEZ98474.1 452 2.4e-42 hypothetical protein TcasGA2_TC000966 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWD0 135 5.7e-07 Gametocyte-specific factor 1-like OS=Mus musculus GN=Gtsf1l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4376 Uncharacterized conserved protein Cluster-8309.45556 BF_2 314.00 10.24 1570 780104265 XP_011675652.1 245 4.0e-18 PREDICTED: zinc finger protein 883 isoform X1 [Strongylocentrotus purpuratus] -- -- -- -- -- K09207 KLF6_7 krueppel-like factor 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K09207 Q5VIY5 232 5.3e-18 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF00797//PF04931//PF00096//PF13465 N-acetyltransferase//DNA polymerase phi//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006351//GO:0008152//GO:0042967//GO:0006260 transcription, DNA-templated//metabolic process//acyl-carrier-protein biosynthetic process//DNA replication GO:0003677//GO:0016407//GO:0003887//GO:0046872 DNA binding//acetyltransferase activity//DNA-directed DNA polymerase activity//metal ion binding GO:0042575 DNA polymerase complex -- -- Cluster-8309.45557 BF_2 17.23 0.33 2468 642933896 XP_971172.2 1523 4.0e-166 PREDICTED: dual specificity testis-specific protein kinase 2 [Tribolium castaneum] 564254917 XM_006266377.1 95 1.72641e-39 PREDICTED: Alligator mississippiensis dual specificity testis-specific protein kinase 1-like (LOC102574118), mRNA K08842 TESK2 testis-specific kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08842 Q96S53 892 2.4e-94 Dual specificity testis-specific protein kinase 2 OS=Homo sapiens GN=TESK2 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.45561 BF_2 19.46 0.80 1300 546676040 ERL87123.1 220 2.6e-15 hypothetical protein D910_04523 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45562 BF_2 300.00 8.97 1686 642912158 XP_008200830.1 1263 3.9e-136 PREDICTED: tRNA pseudouridine synthase A, mitochondrial [Tribolium castaneum] -- -- -- -- -- K06173 truA, PUS1 tRNA pseudouridine38-40 synthase http://www.genome.jp/dbget-bin/www_bget?ko:K06173 Q9WU56 870 5.9e-92 tRNA pseudouridine synthase A, mitochondrial OS=Mus musculus GN=Pus1 PE=1 SV=2 PF01416 tRNA pseudouridine synthase GO:0009451//GO:0001522 RNA modification//pseudouridine synthesis GO:0003723//GO:0009982 RNA binding//pseudouridine synthase activity -- -- KOG2553 Pseudouridylate synthase Cluster-8309.45563 BF_2 411.15 5.43 3452 558201797 XP_006131692.1 250 2.3e-18 PREDICTED: zinc finger protein 135-like, partial [Pelodiscus sinensis] 667677333 AE014297.3 36 1.52161e-06 Drosophila melanogaster chromosome 3R K09208 KLF9S, BTEB krueppel-like factor 9/13/14/16 http://www.genome.jp/dbget-bin/www_bget?ko:K09208 Q9Y2Y9 455 1.6e-43 Krueppel-like factor 13 OS=Homo sapiens GN=KLF13 PE=1 SV=1 PF13465//PF02176//PF00096//PF13912 Zinc-finger double domain//TRAF-type zinc finger//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.45564 BF_2 209.94 2.55 3733 642913781 XP_008201158.1 1088 1.7e-115 PREDICTED: programmed cell death protein 2-like [Tribolium castaneum] -- -- -- -- -- K14801 TSR4 pre-rRNA-processing protein TSR4 http://www.genome.jp/dbget-bin/www_bget?ko:K14801 Q8C5N5 232 1.3e-17 Programmed cell death protein 2-like OS=Mus musculus GN=Pdcd2l PE=2 SV=1 PF04194//PF01150 Programmed cell death protein 2, C-terminal putative domain//GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity GO:0005737 cytoplasm KOG2061 Uncharacterized MYND Zn-finger protein Cluster-8309.45565 BF_2 53.00 1.41 1865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45571 BF_2 59.22 0.54 4858 642935897 XP_008198219.1 936 9.2e-98 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X2 [Tribolium castaneum] 688627348 LL261331.1 74 1.61409e-27 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 -- -- -- -- Q8NA58 326 2.0e-28 Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.45573 BF_2 577.89 7.86 3362 642928048 XP_008200135.1 1024 4.0e-108 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 3.2e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF05104//PF04508//PF09392 Ribosome receptor lysine/proline rich region//Viral A-type inclusion protein repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0009405//GO:0016032//GO:0015031 pathogenesis//viral process//protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45574 BF_2 854.50 11.81 3314 642928044 XP_008200132.1 982 2.9e-103 PREDICTED: ribosome-binding protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P2E9 264 2.2e-21 Ribosome-binding protein 1 OS=Homo sapiens GN=RRBP1 PE=1 SV=4 PF09392//PF04508//PF05104 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Viral A-type inclusion protein repeat//Ribosome receptor lysine/proline rich region GO:0016032//GO:0009405//GO:0015031 viral process//pathogenesis//protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45575 BF_2 725.78 10.38 3212 642928048 XP_008200135.1 946 4.2e-99 PREDICTED: early endosome antigen 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 254 3.0e-20 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF05104//PF04508//PF09392 Ribosome receptor lysine/proline rich region//Viral A-type inclusion protein repeat//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0015031//GO:0016032//GO:0009405 protein transport//viral process//pathogenesis -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45578 BF_2 23.28 0.51 2204 642928046 XP_008200133.1 748 2.6e-76 PREDICTED: ribosome-binding protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1D823 186 1.6e-12 Adventurous-gliding motility protein Z OS=Myxococcus xanthus (strain DK 1622) GN=aglZ PE=1 SV=1 PF05104 Ribosome receptor lysine/proline rich region GO:0015031 protein transport -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.45582 BF_2 534.98 11.55 2224 642934675 XP_008197763.1 2437 3.7e-272 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 556762122 XM_005976302.1 125 3.26843e-56 PREDICTED: Pantholops hodgsonii adenylate cyclase 1 (brain) (ADCY1), mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1565 2.0e-172 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.45583 BF_2 48.15 0.42 5029 642934675 XP_008197763.1 2238 1.0e-248 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 642934684 XM_008199547.1 110 1.6247e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1576 2.4e-173 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0016114//GO:0035556//GO:0009190 terpenoid biosynthetic process//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0008685//GO:0016849 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity//phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.45585 BF_2 23.69 0.85 1458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45586 BF_2 144.77 4.30 1694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45587 BF_2 173.29 2.56 3124 642918017 XP_008198981.1 462 5.4e-43 PREDICTED: protein LSM14 homolog B isoform X2 [Tribolium castaneum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q566L7 195 2.0e-13 Protein LSM14 homolog B OS=Xenopus tropicalis GN=lsm14b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.45589 BF_2 209.20 2.07 4523 270016526 EFA12972.1 942 1.7e-98 hypothetical protein TcasGA2_TC010996 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 561 1.1e-55 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF09198 Bacteriophage T4 beta-glucosyltransferase GO:0006304 DNA modification GO:0033821 DNA beta-glucosyltransferase activity -- -- KOG3097 Predicted membrane protein Cluster-8309.45590 BF_2 30.01 0.95 1603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45592 BF_2 149.00 2.37 2915 384255136 AFH75400.1 3825 0.0e+00 elongation factor 2 [Eriocheir sinensis] 393395827 JQ824131.1 2380 0 Scylla paramamosain elongation factor 2 mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 Q1HPK6 3203 0.0e+00 Translation elongation factor 2 OS=Bombyx mori GN=tef2 PE=1 SV=1 PF03764//PF03144//PF06881 Elongation factor G, domain IV//Elongation factor Tu domain 2//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated GO:0005525 GTP binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0469 Elongation factor 2 Cluster-8309.45593 BF_2 2997.89 61.72 2319 189234402 XP_974971.2 3224 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 1858 2.2e-206 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF01414//PF00008 Delta serrate ligand//EGF-like domain GO:0007154 cell communication GO:0005515 protein binding GO:0016020 membrane KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.45594 BF_2 29.42 0.66 2161 189234402 XP_974971.2 3224 0.0e+00 PREDICTED: multiple epidermal growth factor-like domains protein 10 isoform X1 [Tribolium castaneum]>gi|270002777|gb|EEZ99224.1| draper [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 1858 2.1e-206 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF00008//PF01414 EGF-like domain//Delta serrate ligand GO:0007154 cell communication GO:0005515 protein binding GO:0016020 membrane KOG1218 Proteins containing Ca2+-binding EGF-like domains Cluster-8309.45595 BF_2 6.00 0.92 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45597 BF_2 292.26 5.56 2488 642918750 XP_008191568.1 1074 4.7e-114 PREDICTED: palmitoyltransferase ZDHHC7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91WU6 360 1.2e-32 Palmitoyltransferase ZDHHC7 OS=Mus musculus GN=Zdhhc7 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.45599 BF_2 543.00 14.33 1872 91088645 XP_974426.1 423 1.1e-38 PREDICTED: calcium-binding and coiled-coil domain-containing protein 2 [Tribolium castaneum]>gi|270011685|gb|EFA08133.1| hypothetical protein TcasGA2_TC005737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R914 211 1.7e-15 Calcium-binding and coiled-coil domain-containing protein 2 OS=Macaca fascicularis GN=CALCOCO2 PE=2 SV=1 PF02050//PF00038//PF07544//PF06156//PF07851//PF04111//PF10174//PF13851//PF10186//PF05440 Flagellar FliJ protein//Intermediate filament protein//RNA polymerase II transcription mediator complex subunit 9//Protein of unknown function (DUF972)//TMPIT-like protein//Autophagy protein Apg6//RIM-binding protein of the cytomatrix active zone//Growth-arrest specific micro-tubule binding//Vacuolar sorting 38 and autophagy-related subunit 14//Tetrahydromethanopterin S-methyltransferase subunit B GO:0048870//GO:0071973//GO:0006935//GO:0015948//GO:0010508//GO:0006260//GO:0006357//GO:0046656//GO:0006914 cell motility//bacterial-type flagellum-dependent cell motility//chemotaxis//methanogenesis//positive regulation of autophagy//DNA replication//regulation of transcription from RNA polymerase II promoter//folic acid biosynthetic process//autophagy GO:0003774//GO:0001104//GO:0005198//GO:0030269 motor activity//RNA polymerase II transcription cofactor activity//structural molecule activity//tetrahydromethanopterin S-methyltransferase activity GO:0016020//GO:0016592//GO:0048786//GO:0009288//GO:0005882//GO:0031514//GO:0016021 membrane//mediator complex//presynaptic active zone//bacterial-type flagellum//intermediate filament//motile cilium//integral component of membrane -- -- Cluster-8309.45601 BF_2 102.91 0.71 6351 642923135 XP_008193624.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 2 isoform X3 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.2e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF08447//PF00010//PF00989 PAS fold//Helix-loop-helix DNA-binding domain//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.45602 BF_2 92.13 2.37 1914 642937984 XP_008199157.1 229 3.5e-16 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45603 BF_2 488.29 28.78 997 189234473 XP_001808764.1 1192 3.9e-128 PREDICTED: double-strand-break repair protein rad21 homolog isoform X1 [Tribolium castaneum]>gi|270002814|gb|EEZ99261.1| rad21 [Tribolium castaneum] 662206050 XM_008478247.1 93 8.84216e-39 PREDICTED: Diaphorina citri double-strand-break repair protein rad21 homolog (LOC103513421), mRNA K06670 SCC1, MCD1, RAD21 cohesin complex subunit SCC1 http://www.genome.jp/dbget-bin/www_bget?ko:K06670 Q61550 725 2.3e-75 Double-strand-break repair protein rad21 homolog OS=Mus musculus GN=Rad21 PE=1 SV=3 PF06766//PF04825 Fungal hydrophobin//N terminus of Rad21 / Rec8 like protein -- -- GO:0005515 protein binding GO:0005576//GO:0000228 extracellular region//nuclear chromosome KOG1213 Sister chromatid cohesion complex Cohesin, subunit RAD21/SCC1 Cluster-8309.45604 BF_2 719.72 14.63 2345 642912121 XP_008200815.1 1300 2.7e-140 PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|642912123|ref|XP_008200816.1| PREDICTED: spermine oxidase-like [Tribolium castaneum]>gi|270002494|gb|EEZ98941.1| hypothetical protein TcasGA2_TC004564 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 414 6.2e-39 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF00070//PF07664//PF00899//PF01134//PF01266//PF01593//PF12831//PF07992//PF01494 Pyridine nucleotide-disulphide oxidoreductase//Ferrous iron transport protein B C terminus//ThiF family//Glucose inhibited division protein A//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain GO:0008033//GO:0015684//GO:0055114 tRNA processing//ferrous iron transport//oxidation-reduction process GO:0008641//GO:0050660//GO:0016491//GO:0071949//GO:0015093 small protein activating enzyme activity//flavin adenine dinucleotide binding//oxidoreductase activity//FAD binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.45606 BF_2 139.77 0.67 9071 642933690 XP_008197522.1 457 6.0e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 227 1.2e-16 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF02179//PF04048 BAG domain//Sec8 exocyst complex component specific domain GO:0015031//GO:0006904 protein transport//vesicle docking involved in exocytosis GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.45609 BF_2 1134.82 13.00 3938 91081191 XP_975602.1 3797 0.0e+00 PREDICTED: N-alpha-acetyltransferase 16, NatA auxiliary subunit isoform X2 [Tribolium castaneum]>gi|270006047|gb|EFA02495.1| hypothetical protein TcasGA2_TC008190 [Tribolium castaneum] 642920290 XM_970509.2 763 0 PREDICTED: Tribolium castaneum N-alpha-acetyltransferase 16, NatA auxiliary subunit (LOC664508), transcript variant X3, mRNA K00670 E2.3.1.88 peptide alpha-N-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00670 Q5R4J9 2511 7.2e-282 N-alpha-acetyltransferase 15, NatA auxiliary subunit OS=Pongo abelii GN=NAA15 PE=2 SV=1 PF13371//PF00515//PF13414//PF13176//PF06552//PF03601//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Plant specific mitochondrial import receptor subunit TOM20//Conserved hypothetical protein 698//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0045040 protein import into mitochondrial outer membrane GO:0005515 protein binding GO:0005742//GO:0016021 mitochondrial outer membrane translocase complex//integral component of membrane KOG1156 N-terminal acetyltransferase Cluster-8309.45610 BF_2 8.82 0.48 1055 270010513 EFA06961.1 680 9.7e-69 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03568 Peptidase family C50 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0005634 nucleus -- -- Cluster-8309.45611 BF_2 20.58 1.30 951 642929360 XP_008195803.1 784 7.6e-81 PREDICTED: separin [Tribolium castaneum] -- -- -- -- -- K02365 ESP1 separase http://www.genome.jp/dbget-bin/www_bget?ko:K02365 P60330 267 2.8e-22 Separin OS=Mus musculus GN=Espl1 PE=1 SV=1 PF03568 Peptidase family C50 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0005634 nucleus KOG1849 Regulator of spindle pole body duplication Cluster-8309.45612 BF_2 6.00 0.76 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45613 BF_2 189.00 2.99 2928 281369846 BAI59107.1 972 3.7e-102 serpin55 [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q1JPB0 246 2.3e-19 Leukocyte elastase inhibitor OS=Bos taurus GN=SERPINB1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2392 Serpin Cluster-8309.45615 BF_2 63.17 0.37 7470 662212467 XP_008479970.1 158 2.3e-07 PREDICTED: zinc finger protein 425-like [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF04810//PF00412//PF13912//PF01155//PF00096//PF13465 zinc-finger C2H2-type//Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006886//GO:0006888//GO:0006464 intracellular protein transport//ER to Golgi vesicle-mediated transport//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.45617 BF_2 179.31 7.25 1322 478257606 ENN77758.1 157 5.4e-08 hypothetical protein YQE_05730, partial [Dendroctonus ponderosae]>gi|546677510|gb|ERL88336.1| hypothetical protein D910_05723 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45618 BF_2 34.00 1.21 1466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45619 BF_2 296.04 9.51 1590 91087061 XP_974794.1 1218 6.0e-131 PREDICTED: retrograde Golgi transport protein RGP1 homolog [Tribolium castaneum]>gi|270010531|gb|EFA06979.1| hypothetical protein TcasGA2_TC009939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92546 492 3.8e-48 RAB6A-GEF complex partner protein 2 OS=Homo sapiens GN=RGP1 PE=1 SV=1 PF04216 Protein involved in formate dehydrogenase formation -- -- -- -- GO:0005737 cytoplasm KOG4469 Uncharacterized conserved protein Cluster-8309.45620 BF_2 2047.95 68.44 1539 91076824 XP_967870.1 885 2.4e-92 PREDICTED: fatty-acid amide hydrolase 2-B [Tribolium castaneum]>gi|270001790|gb|EEZ98237.1| hypothetical protein TcasGA2_TC000676 [Tribolium castaneum] -- -- -- -- -- K19176 FAAH2 fatty acid amide hydrolase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K19176 Q6DH69 565 1.3e-56 Fatty-acid amide hydrolase 2-A OS=Danio rerio GN=faah2a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1212 Amidases Cluster-8309.45621 BF_2 2179.87 69.99 1590 741829289 AJA91071.1 1030 3.8e-109 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 738 1.1e-76 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.45623 BF_2 94.96 0.47 8686 390362249 XP_001190749.2 1116 2.2e-118 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 976 1.6e-103 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.45625 BF_2 64.06 1.77 1803 642928935 XP_008195623.1 238 3.0e-17 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q9VCX1 139 3.7e-07 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 -- -- GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.45626 BF_2 41.16 0.53 3517 642912272 XP_008200632.1 770 1.2e-78 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 8.7e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089 Delta serrate ligand//Trypsin GO:0006508//GO:0007154 proteolysis//cell communication GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.45628 BF_2 82.26 1.35 2835 91082797 XP_967743.1 715 2.3e-72 PREDICTED: COMM domain-containing protein 2 [Tribolium castaneum]>gi|270007580|gb|EFA04028.1| hypothetical protein TcasGA2_TC014257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BXC6 372 5.5e-34 COMM domain-containing protein 2 OS=Mus musculus GN=Commd2 PE=1 SV=1 PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.45629 BF_2 20.00 1.68 786 546682961 ERL92838.1 1171 8.4e-126 hypothetical protein D910_10145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9UM47 242 1.8e-19 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.4563 BF_2 13.23 0.36 1837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45632 BF_2 71.17 0.36 8592 642918656 XP_008191524.1 2229 1.9e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.3e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF07535//PF06220//PF00463//PF00069//PF01799//PF00433//PF07714 DBF zinc finger//U1 zinc finger//Isocitrate lyase family//Protein kinase domain//[2Fe-2S] binding domain//Protein kinase C terminal domain//Protein tyrosine kinase GO:0019752//GO:0016310//GO:0009069//GO:0006468//GO:0006097//GO:0055114 carboxylic acid metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation//glyoxylate cycle//oxidation-reduction process GO:0004451//GO:0016491//GO:0005543//GO:0005524//GO:0046872//GO:0004674//GO:0004672//GO:0003676//GO:0008270 isocitrate lyase activity//oxidoreductase activity//phospholipid binding//ATP binding//metal ion binding//protein serine/threonine kinase activity//protein kinase activity//nucleic acid binding//zinc ion binding -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.45634 BF_2 351.81 10.94 1633 282158103 NP_001164095.1 1643 3.2e-180 ATP-dependent RNA helicase p62 [Tribolium castaneum]>gi|642939024|ref|XP_008200192.1| PREDICTED: ATP-dependent RNA helicase p62 isoform X1 [Tribolium castaneum] 195492386 XM_002093932.1 172 1.78039e-82 Drosophila yakuba GE20460 (Dyak\GE20460), partial mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 P19109 1360 8.7e-149 ATP-dependent RNA helicase p62 OS=Drosophila melanogaster GN=Rm62 PE=1 SV=3 PF00270//PF06273//PF03141//PF04851 DEAD/DEAH box helicase//Plant specific eukaryotic initiation factor 4B//Putative S-adenosyl-L-methionine-dependent methyltransferase//Type III restriction enzyme, res subunit GO:0006446 regulation of translational initiation GO:0003743//GO:0016787//GO:0003677//GO:0005524//GO:0003676//GO:0008168 translation initiation factor activity//hydrolase activity//DNA binding//ATP binding//nucleic acid binding//methyltransferase activity GO:0005840 ribosome KOG0331 ATP-dependent RNA helicase Cluster-8309.45639 BF_2 128.66 1.72 3425 642937037 XP_008198662.1 2915 0.0e+00 PREDICTED: cytoplasmic dynein 1 intermediate chain isoform X3 [Tribolium castaneum] 642937036 XM_008200440.1 584 0 PREDICTED: Tribolium castaneum cytoplasmic dynein 1 intermediate chain (LOC657386), transcript variant X3, mRNA K10415 DYNC1I, DNCI dynein intermediate chain, cytosolic http://www.genome.jp/dbget-bin/www_bget?ko:K10415 Q24246 2063 5.5e-230 Cytoplasmic dynein 1 intermediate chain OS=Drosophila melanogaster GN=sw PE=1 SV=3 PF11540//PF09266//PF00400 Cytoplasmic dynein 1 intermediate chain 2//Viral DNA topoisomerase I, N-terminal//WD domain, G-beta repeat GO:0006265//GO:0007018 DNA topological change//microtubule-based movement GO:0003916//GO:0005515//GO:0003677 DNA topoisomerase activity//protein binding//DNA binding GO:0005868 cytoplasmic dynein complex KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.45640 BF_2 25.00 0.83 1546 307168739 EFN61742.1 152 2.4e-07 hypothetical protein EAG_13055, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45641 BF_2 25.00 0.39 2996 332375280 AEE62781.1 555 8.6e-54 unknown [Dendroctonus ponderosae]>gi|478256834|gb|ENN77009.1| hypothetical protein YQE_06503, partial [Dendroctonus ponderosae] 815824285 XM_012378064.1 88 1.63469e-35 PREDICTED: Linepithema humile dnaJ homolog subfamily C member 8 (LOC105678594), mRNA K09528 DNAJC8 DnaJ homolog subfamily C member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09528 O75937 382 4.1e-35 DnaJ homolog subfamily C member 8 OS=Homo sapiens GN=DNAJC8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1150 Predicted molecular chaperone (DnaJ superfamily) Cluster-8309.45646 BF_2 15.70 0.41 1904 642910558 XP_008200265.1 957 1.3e-100 PREDICTED: ras-related protein Rab6 isoform X2 [Tribolium castaneum]>gi|270014377|gb|EFA10825.1| hypothetical protein TcasGA2_TC001600 [Tribolium castaneum] 676425887 XM_009046199.1 171 7.48935e-82 Lottia gigantea hypothetical protein mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 933 3.3e-99 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF08477//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0015031//GO:0007264 protein transport//small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.45647 BF_2 73.19 0.68 4760 478254040 ENN74332.1 1807 9.1e-199 hypothetical protein YQE_09302, partial [Dendroctonus ponderosae]>gi|546686146|gb|ERL95532.1| hypothetical protein D910_12794 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q502I9 789 4.1e-82 F-BAR domain only protein 2 OS=Danio rerio GN=fcho2 PE=2 SV=1 PF13326//PF02050//PF01442//PF02662 Photosystem II Pbs27//Flagellar FliJ protein//Apolipoprotein A1/A4/E domain//Methyl-viologen-reducing hydrogenase, delta subunit GO:0071973//GO:0006869//GO:0006935//GO:0042157//GO:0015948//GO:0055114//GO:0010207 bacterial-type flagellum-dependent cell motility//lipid transport//chemotaxis//lipoprotein metabolic process//methanogenesis//oxidation-reduction process//photosystem II assembly GO:0008289//GO:0003774 lipid binding//motor activity GO:0016020//GO:0005576//GO:0009288 membrane//extracellular region//bacterial-type flagellum KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.45649 BF_2 281.47 1.70 7225 642930298 XP_008196335.1 3056 0.0e+00 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X1 [Tribolium castaneum] 642930305 XM_008198117.1 1318 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 1577 2.6e-173 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF01676//PF00520 Metalloenzyme superfamily//Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0003824//GO:0005216//GO:0046872 catalytic activity//ion channel activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.45651 BF_2 534.01 10.92 2332 91081173 XP_975583.1 1226 1.0e-131 PREDICTED: mitochondrial 2-oxodicarboxylate carrier [Tribolium castaneum]>gi|270006043|gb|EFA02491.1| hypothetical protein TcasGA2_TC008186 [Tribolium castaneum] -- -- -- -- -- K15110 SLC25A21, ODC solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15110 Q9BQT8 888 6.7e-94 Mitochondrial 2-oxodicarboxylate carrier OS=Homo sapiens GN=SLC25A21 PE=1 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0754 Mitochondrial oxodicarboxylate carrier protein Cluster-8309.45653 BF_2 6.30 0.38 973 835482914 AKM70276.1 143 1.7e-06 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06974 Protein of unknown function (DUF1298) GO:0042967//GO:0046486 acyl-carrier-protein biosynthetic process//glycerolipid metabolic process GO:0004144 diacylglycerol O-acyltransferase activity -- -- -- -- Cluster-8309.45655 BF_2 689.00 56.76 795 478256590 ENN76772.1 465 6.2e-44 hypothetical protein YQE_06613, partial [Dendroctonus ponderosae] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q45VV3 215 2.5e-16 Transcriptional coactivator yorkie OS=Drosophila melanogaster GN=yki PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45656 BF_2 374.69 6.27 2788 642911706 XP_008200710.1 705 3.2e-71 PREDICTED: yorkie homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q9EPK5 283 1.1e-23 WW domain-containing transcription regulator protein 1 OS=Mus musculus GN=Wwtr1 PE=1 SV=2 PF00397//PF03153 WW domain//Transcription factor IIA, alpha/beta subunit GO:0006367 transcription initiation from RNA polymerase II promoter GO:0005515 protein binding GO:0005672 transcription factor TFIIA complex KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.45657 BF_2 15.59 0.70 1214 91076148 XP_970492.1 742 7.2e-76 PREDICTED: yorkie homolog isoform X1 [Tribolium castaneum]>gi|270014715|gb|EFA11163.1| hypothetical protein TcasGA2_TC004769 [Tribolium castaneum] -- -- -- -- -- K16687 YAP1, Yki protein yorkie http://www.genome.jp/dbget-bin/www_bget?ko:K16687 Q45VV3 309 4.8e-27 Transcriptional coactivator yorkie OS=Drosophila melanogaster GN=yki PE=1 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.45658 BF_2 419.39 4.37 4298 91089273 XP_966340.1 958 2.3e-100 PREDICTED: autophagy-related protein 101 [Tribolium castaneum]>gi|270011443|gb|EFA07891.1| hypothetical protein TcasGA2_TC005466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH75 708 9.2e-73 Autophagy-related protein 101 OS=Xenopus tropicalis GN=atg101 PE=2 SV=1 PF02907 Hepatitis C virus NS3 protease GO:0006508//GO:0019087 proteolysis//transformation of host cell by virus GO:0008236 serine-type peptidase activity -- -- KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.45659 BF_2 148.04 2.13 3194 91092536 XP_967769.1 2382 1.3e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.3e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.45660 BF_2 164.00 17.42 681 546681776 ERL91802.1 199 3.7e-13 hypothetical protein D910_09127 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45661 BF_2 254.54 3.09 3734 91080499 XP_971142.1 1091 7.5e-116 PREDICTED: 5'-AMP-activated protein kinase subunit beta-1 [Tribolium castaneum]>gi|270005556|gb|EFA02004.1| hypothetical protein TcasGA2_TC007626 [Tribolium castaneum] 332376520 BT128443.1 148 9.04263e-69 Dendroctonus ponderosae clone DPO1136_F01 unknown mRNA K07199 PRKAB 5'-AMP-activated protein kinase, regulatory beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07199 Q5BIS9 672 1.2e-68 5'-AMP-activated protein kinase subunit beta-1 OS=Bos taurus GN=PRKAB1 PE=2 SV=3 PF02892//PF04739//PF13912//PF00320//PF16622//PF13465//PF05443//PF02922//PF07503//PF00096 BED zinc finger//5'-AMP-activated protein kinase beta subunit, interaction domain//C2H2-type zinc finger//GATA zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein//Carbohydrate-binding module 48 (Isoamylase N-terminal domain)//HypF finger//Zinc finger, C2H2 type GO:0006355//GO:0005975 regulation of transcription, DNA-templated//carbohydrate metabolic process GO:0004553//GO:0003677//GO:0005515//GO:0008270//GO:0043565//GO:0046872//GO:0003700 hydrolase activity, hydrolyzing O-glycosyl compounds//DNA binding//protein binding//zinc ion binding//sequence-specific DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1616 Protein involved in Snf1 protein kinase complex assembly Cluster-8309.45662 BF_2 377.72 3.85 4391 332376575 AEE63427.1 1298 8.8e-140 unknown [Dendroctonus ponderosae]>gi|546673735|gb|ERL85291.1| hypothetical protein D910_02712 [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5FWL7 826 1.9e-86 Palmitoyltransferase ZDHHC15 OS=Xenopus laevis GN=zdhhc15 PE=2 SV=1 PF00219//PF01529//PF01309//PF02714 Insulin-like growth factor binding protein//DHHC palmitoyltransferase//Equine arteritis virus small envelope glycoprotein//Calcium-dependent channel, 7TM region, putative phosphate GO:0001558 regulation of cell growth GO:0005520//GO:0008270 insulin-like growth factor binding//zinc ion binding GO:0016942//GO:0019031//GO:0016020//GO:0005576 insulin-like growth factor binding protein complex//viral envelope//membrane//extracellular region KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.45663 BF_2 49.50 0.49 4542 332376575 AEE63427.1 1358 1.0e-146 unknown [Dendroctonus ponderosae]>gi|546673735|gb|ERL85291.1| hypothetical protein D910_02712 [Dendroctonus ponderosae] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q5FWL7 833 3.1e-87 Palmitoyltransferase ZDHHC15 OS=Xenopus laevis GN=zdhhc15 PE=2 SV=1 PF02714//PF01309//PF01529//PF00219 Calcium-dependent channel, 7TM region, putative phosphate//Equine arteritis virus small envelope glycoprotein//DHHC palmitoyltransferase//Insulin-like growth factor binding protein GO:0001558 regulation of cell growth GO:0008270//GO:0005520 zinc ion binding//insulin-like growth factor binding GO:0005576//GO:0016020//GO:0019031//GO:0016942 extracellular region//membrane//viral envelope//insulin-like growth factor binding protein complex KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.45666 BF_2 499.35 7.43 3098 642930161 XP_008196278.1 3054 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [Tribolium castaneum]>gi|642930163|ref|XP_008196279.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [Tribolium castaneum]>gi|642930165|ref|XP_008196280.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 6.0e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00989//PF00072//PF05504//PF00233//PF09771 PAS fold//Response regulator receiver domain//Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188 GO:0006144//GO:0000160//GO:0035307//GO:0007165//GO:0009847//GO:0006355 purine nucleobase metabolic process//phosphorelay signal transduction system//positive regulation of protein dephosphorylation//signal transduction//spore germination//regulation of transcription, DNA-templated GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.45671 BF_2 1088.92 12.67 3881 91090029 XP_967684.1 2946 0.0e+00 PREDICTED: glycerol-3-phosphate acyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270013527|gb|EFA09975.1| hypothetical protein TcasGA2_TC012134 [Tribolium castaneum] 462277993 APGK01058794.1 35 6.15996e-06 Dendroctonus ponderosae Seq01058804, whole genome shotgun sequence K00629 GPAT1_2 glycerol-3-phosphate O-acyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00629 P97564 1000 1.1e-106 Glycerol-3-phosphate acyltransferase 1, mitochondrial OS=Rattus norvegicus GN=Gpam PE=1 SV=3 PF01553//PF00620 Acyltransferase//RhoGAP domain GO:0046486//GO:0008654//GO:0008152//GO:0007165//GO:0042967 glycerolipid metabolic process//phospholipid biosynthetic process//metabolic process//signal transduction//acyl-carrier-protein biosynthetic process GO:0016746//GO:0004366 transferase activity, transferring acyl groups//glycerol-3-phosphate O-acyltransferase activity GO:0016020 membrane KOG3729 Mitochondrial glycerol-3-phosphate acyltransferase GPAT Cluster-8309.45672 BF_2 645.87 16.08 1967 189237918 XP_001811805.1 2207 1.5e-245 PREDICTED: transcription initiation factor TFIID subunit 6 [Tribolium castaneum]>gi|270006675|gb|EFA03123.1| hypothetical protein TcasGA2_TC013033 [Tribolium castaneum] 762091727 XM_011429969.1 66 1.81142e-23 PREDICTED: Crassostrea gigas transcription initiation factor TFIID subunit 6-like (LOC105328924), mRNA K03131 TAF6 transcription initiation factor TFIID subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K03131 P49847 1590 2.2e-175 Transcription initiation factor TFIID subunit 6 OS=Drosophila melanogaster GN=Taf6 PE=1 SV=2 PF08769//PF00125//PF07571//PF02969 Sporulation initiation factor Spo0A C terminal//Core histone H2A/H2B/H3/H4//TAF6 C-terminal HEAT repeat domain//TATA box binding protein associated factor (TAF) GO:0051090//GO:0006352//GO:0042173//GO:0006355 regulation of sequence-specific DNA binding transcription factor activity//DNA-templated transcription, initiation//regulation of sporulation resulting in formation of a cellular spore//regulation of transcription, DNA-templated GO:0046982//GO:0003677//GO:0003700//GO:0005509 protein heterodimerization activity//DNA binding//transcription factor activity, sequence-specific DNA binding//calcium ion binding GO:0005667//GO:0005634//GO:0005737 transcription factor complex//nucleus//cytoplasm KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.45675 BF_2 7.62 0.37 1149 91085321 XP_969715.1 722 1.4e-73 PREDICTED: lactoylglutathione lyase [Tribolium castaneum]>gi|270009130|gb|EFA05578.1| hypothetical protein TcasGA2_TC015771 [Tribolium castaneum] -- -- -- -- -- K01759 GLO1, gloA lactoylglutathione lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01759 Q6P7Q4 638 3.2e-65 Lactoylglutathione lyase OS=Rattus norvegicus GN=Glo1 PE=1 SV=3 -- -- GO:0005975//GO:0006090 carbohydrate metabolic process//pyruvate metabolic process GO:0004462//GO:0046872 lactoylglutathione lyase activity//metal ion binding -- -- KOG2944 Glyoxalase Cluster-8309.45676 BF_2 437.50 4.06 4790 642918008 XP_008198978.1 844 4.2e-87 PREDICTED: E3 ubiquitin-protein ligase rnf146 [Tribolium castaneum] -- -- -- -- -- K15700 RNF146 E3 ubiquitin-protein ligase RNF146 http://www.genome.jp/dbget-bin/www_bget?ko:K15700 Q5XIK5 576 2.1e-57 E3 ubiquitin-protein ligase RNF146 OS=Rattus norvegicus GN=Rnf146 PE=2 SV=1 PF08445//PF13302//PF13508//PF00583//PF13639//PF16685//PF12678//PF14634//PF00097//PF13673 FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//Ring finger domain//zinc RING finger of MSL2//RING-H2 zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0046872//GO:0005515//GO:0061630//GO:0008080//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//metal ion binding//protein binding//ubiquitin protein ligase activity//N-acetyltransferase activity//zinc ion binding -- -- KOG0824 Predicted E3 ubiquitin ligase Cluster-8309.45677 BF_2 172.35 3.26 2496 91082351 XP_967256.1 877 3.3e-91 PREDICTED: probable uridine nucleosidase 1 [Tribolium castaneum]>gi|270007493|gb|EFA03941.1| hypothetical protein TcasGA2_TC014082 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8AJF8 263 2.1e-21 Pyrimidine-specific ribonucleoside hydrolase RihA OS=Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696) GN=rihA PE=3 SV=1 PF02212//PF01496//PF01105//PF06156 Dynamin GTPase effector domain//V-type ATPase 116kDa subunit family//emp24/gp25L/p24 family/GOLD//Protein of unknown function (DUF972) GO:0015991//GO:0006810//GO:0006260//GO:0015992 ATP hydrolysis coupled proton transport//transport//DNA replication//proton transport GO:0003924//GO:0015078//GO:0005525 GTPase activity//hydrogen ion transmembrane transporter activity//GTP binding GO:0016021//GO:0033179 integral component of membrane//proton-transporting V-type ATPase, V0 domain KOG2938 Predicted inosine-uridine preferring nucleoside hydrolase Cluster-8309.45680 BF_2 34.16 2.82 793 642928567 XP_008199961.1 327 6.2e-28 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 Q9VVR9 212 5.5e-16 Probable cytochrome P450 12c1, mitochondrial OS=Drosophila melanogaster GN=Cyp12c1 PE=2 SV=2 PF11057//PF00067 Cortexin of kidney//Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0031224 intrinsic component of membrane -- -- Cluster-8309.45684 BF_2 222.96 0.87 11026 642922880 XP_008200435.1 5420 0.0e+00 PREDICTED: maestro heat-like repeat-containing protein family member 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDA8 1179 5.7e-127 Maestro heat-like repeat-containing protein family member 1 OS=Homo sapiens GN=MROH1 PE=2 SV=3 PF05485//PF02985//PF10288//PF01429//PF11698//PF00628//PF00096//PF07178 THAP domain//HEAT repeat//Cytoplasmic tRNA 2-thiolation protein 2//Methyl-CpG binding domain//V-ATPase subunit H//PHD-finger//Zinc finger, C2H2 type//TraL protein GO:0002098//GO:0015991//GO:0034227//GO:0000746 tRNA wobble uridine modification//ATP hydrolysis coupled proton transport//tRNA thio-modification//conjugation GO:0016820//GO:0000049//GO:0005515//GO:0003677//GO:0046872//GO:0003676 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//tRNA binding//protein binding//DNA binding//metal ion binding//nucleic acid binding GO:0000221//GO:0005634//GO:0019867 vacuolar proton-transporting V-type ATPase, V1 domain//nucleus//outer membrane KOG2032 Uncharacterized conserved protein Cluster-8309.45685 BF_2 362.13 5.39 3096 332375600 AEE62941.1 1416 1.3e-153 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7T3C7 340 3.1e-30 Reticulon-4-interacting protein 1 homolog, mitochondrial OS=Danio rerio GN=rtn4ip1 PE=2 SV=2 PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.45687 BF_2 214.59 2.63 3698 642921224 XP_008192769.1 1938 4.5e-214 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921223 XM_008194547.1 369 0 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X1, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 652 2.5e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF00023//PF14604//PF00018//PF13606 Ankyrin repeat//Variant SH3 domain//SH3 domain//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.4569 BF_2 1.00 1.46 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45690 BF_2 1054.11 3.91 11557 642917448 XP_008191204.1 2643 2.5e-295 PREDICTED: maternal protein tudor isoform X3 [Tribolium castaneum] -- -- -- -- -- K11457 PHC2, EDR2 polyhomeotic-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11457 P25823 542 4.4e-53 Maternal protein tudor OS=Drosophila melanogaster GN=tud PE=1 SV=2 PF02198//PF00536//PF07647 Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0005634 nucleus -- -- Cluster-8309.45692 BF_2 51.48 2.49 1153 589939228 XP_006982360.1 507 1.2e-48 PREDICTED: zinc finger protein 658B-like [Peromyscus maniculatus bairdii] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q52M93 479 8.8e-47 Zinc finger protein 585B OS=Homo sapiens GN=ZNF585B PE=2 SV=1 PF13465//PF07975//PF13912//PF16622//PF00096//PF01155//PF00130//PF06467//PF07776 Zinc-finger double domain//TFIIH C1-like domain//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD) GO:0035556//GO:0006281//GO:0006464 intracellular signal transduction//DNA repair//cellular protein modification process GO:0016151//GO:0046872//GO:0008270 nickel cation binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45693 BF_2 12.00 0.51 1279 282158087 NP_001164087.1 240 1.2e-17 zinc finger protein TC009514 [Tribolium castaneum]>gi|270010151|gb|EFA06599.1| hypothetical protein TcasGA2_TC009514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.45698 BF_2 275.18 3.32 3759 546679853 ERL90241.1 1277 2.0e-137 hypothetical protein D910_07594 [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 700 6.8e-72 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF16782//PF00916 Nucleotide exchange factor SIL1//Sulfate permease family GO:0008272 sulfate transport GO:0015116//GO:0000774 sulfate transmembrane transporter activity//adenyl-nucleotide exchange factor activity GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.45699 BF_2 683.53 6.76 4517 642914389 XP_008201657.1 2629 4.1e-294 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K08836 SLK STE20-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08836 O54988 1025 1.7e-109 STE20-like serine/threonine-protein kinase OS=Mus musculus GN=Slk PE=1 SV=2 PF00069//PF07714//PF12474 Protein kinase domain//Protein tyrosine kinase//Polo kinase kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004674//GO:0004672//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//ATP binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.45701 BF_2 80.05 7.92 710 91079879 XP_975774.1 464 7.2e-44 PREDICTED: uncharacterized protein LOC655985 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06220//PF04889 U1 zinc finger//Cwf15/Cwc15 cell cycle control protein GO:0000398 mRNA splicing, via spliceosome GO:0008270 zinc ion binding GO:0005681 spliceosomal complex -- -- Cluster-8309.45703 BF_2 164.75 6.10 1417 91094297 XP_971720.1 1187 2.1e-127 PREDICTED: estradiol 17-beta-dehydrogenase 12 [Tribolium castaneum]>gi|270014405|gb|EFA10853.1| hypothetical protein TcasGA2_TC001630 [Tribolium castaneum] -- -- -- -- -- K10251 HSD17B12, KAR, IFA38 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K10251 Q28IU1 690 3.7e-71 Very-long-chain 3-oxoacyl-CoA reductase OS=Xenopus tropicalis GN=hsd17b12 PE=2 SV=1 PF00106//PF02737//PF03435//PF01370//PF10461//PF02882 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//NAD dependent epimerase/dehydratase family//Peptidase S68//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0006550//GO:0006574//GO:0046487//GO:0009396//GO:0006974//GO:0006568//GO:0006915//GO:0006554//GO:0055114//GO:0008152//GO:0006633//GO:0018874//GO:0006631//GO:0006552 isoleucine catabolic process//valine catabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//cellular response to DNA damage stimulus//tryptophan metabolic process//apoptotic process//lysine catabolic process//oxidation-reduction process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//fatty acid metabolic process//leucine catabolic process GO:0050662//GO:0004488//GO:0000166//GO:0003857//GO:0003824//GO:0016491 coenzyme binding//methylenetetrahydrofolate dehydrogenase (NADP+) activity//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity//catalytic activity//oxidoreductase activity -- -- KOG1014 17 beta-hydroxysteroid dehydrogenase type 3, HSD17B3 Cluster-8309.45704 BF_2 55.61 0.70 3613 478256573 ENN76755.1 1419 6.7e-154 hypothetical protein YQE_06596, partial [Dendroctonus ponderosae] -- -- -- -- -- K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 Q99MR0 773 2.2e-80 Actin-like protein 6B OS=Mus musculus GN=Actl6b PE=1 SV=1 PF02487//PF07690 CLN3 protein//Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG3880 Predicted small molecule transporter involved in cellular pH homeostasis (Batten disease protein in human) Cluster-8309.45706 BF_2 73.28 1.02 3302 478256573 ENN76755.1 1419 6.2e-154 hypothetical protein YQE_06596, partial [Dendroctonus ponderosae] -- -- -- -- -- K11652 ACTL6B actin-like protein 6B http://www.genome.jp/dbget-bin/www_bget?ko:K11652 Q99MR0 773 2.0e-80 Actin-like protein 6B OS=Mus musculus GN=Actl6b PE=1 SV=1 PF07690//PF02487 Major Facilitator Superfamily//CLN3 protein GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG3880 Predicted small molecule transporter involved in cellular pH homeostasis (Batten disease protein in human) Cluster-8309.45707 BF_2 426.20 2.13 8668 642916202 XP_008190929.1 540 1.4e-51 PREDICTED: uncharacterized protein LOC103312333 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q59SG9 137 3.0e-06 Probable GPI-anchored adhesin-like protein PGA55 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PGA55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45708 BF_2 435.74 3.12 6126 642916202 XP_008190929.1 462 1.1e-42 PREDICTED: uncharacterized protein LOC103312333 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q59SG9 137 2.1e-06 Probable GPI-anchored adhesin-like protein PGA55 OS=Candida albicans (strain SC5314 / ATCC MYA-2876) GN=PGA55 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45711 BF_2 51.82 0.39 5892 546679844 ERL90232.1 1077 5.0e-114 hypothetical protein D910_07585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 554 9.1e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228//PF01157//PF03561 Stage II sporulation protein E (SpoIIE)//Ribosomal protein L21e//Allantoicase repeat GO:0006807//GO:0042254//GO:0000256//GO:0006412//GO:0006144 nitrogen compound metabolic process//ribosome biogenesis//allantoin catabolic process//translation//purine nucleobase metabolic process GO:0003735//GO:0004037//GO:0003824 structural constituent of ribosome//allantoicase activity//catalytic activity GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.45712 BF_2 101.19 0.93 4840 546679844 ERL90232.1 1077 4.1e-114 hypothetical protein D910_07585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 554 7.4e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228//PF03561 Stage II sporulation protein E (SpoIIE)//Allantoicase repeat GO:0000256//GO:0006807//GO:0006144 allantoin catabolic process//nitrogen compound metabolic process//purine nucleobase metabolic process GO:0003824//GO:0004037 catalytic activity//allantoicase activity -- -- -- -- Cluster-8309.45713 BF_2 8.49 0.40 1179 332372718 AEE61501.1 663 1.0e-66 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08193 SLC17A MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K08193 Q9NRA2 229 8.8e-18 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.45714 BF_2 65.55 1.15 2674 332376166 AEE63223.1 796 8.7e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q86BN8 611 1.0e-61 Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 OS=Drosophila melanogaster GN=Plip PE=2 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1719 Dual specificity phosphatase Cluster-8309.45715 BF_2 33.00 3.04 741 642929725 XP_975551.3 737 1.7e-75 PREDICTED: nuclear pore complex protein Nup133 [Tribolium castaneum] -- -- -- -- -- K14300 NUP133 nuclear pore complex protein Nup133 http://www.genome.jp/dbget-bin/www_bget?ko:K14300 Q8R0G9 187 4.1e-13 Nuclear pore complex protein Nup133 OS=Mus musculus GN=Nup133 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45718 BF_2 71.18 0.48 6441 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.03026e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF05201 CPSF A subunit region//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0033014//GO:0055114 tetrapyrrole biosynthetic process//oxidation-reduction process GO:0003676//GO:0050661//GO:0008883 nucleic acid binding//NADP binding//glutamyl-tRNA reductase activity GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45720 BF_2 959.48 6.33 6631 91087281 XP_975549.1 5068 0.0e+00 PREDICTED: DNA damage-binding protein 1 [Tribolium castaneum]>gi|270010588|gb|EFA07036.1| hypothetical protein TcasGA2_TC010010 [Tribolium castaneum] 347967940 XM_312466.5 190 7.23884e-92 Anopheles gambiae str. PEST AGAP002472-PA (AgaP_AGAP002472) mRNA, complete cds K10610 DDB1 DNA damage-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10610 Q3U1J4 4016 0.0e+00 DNA damage-binding protein 1 OS=Mus musculus GN=Ddb1 PE=1 SV=2 PF03178//PF05201 CPSF A subunit region//Glutamyl-tRNAGlu reductase, N-terminal domain GO:0033014//GO:0055114 tetrapyrrole biosynthetic process//oxidation-reduction process GO:0008883//GO:0050661//GO:0003676 glutamyl-tRNA reductase activity//NADP binding//nucleic acid binding GO:0005634 nucleus KOG1897 Damage-specific DNA binding complex, subunit DDB1 Cluster-8309.45721 BF_2 8.10 0.38 1168 189237923 XP_001810409.1 1226 5.2e-132 PREDICTED: exocyst complex component 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ43 454 7.1e-44 Exocyst complex component 8 OS=Gallus gallus GN=EXOC8 PE=2 SV=1 PF02902//PF07578 Ulp1 protease family, C-terminal catalytic domain//Lipid A Biosynthesis N-terminal domain GO:0009245//GO:0006508 lipid A biosynthetic process//proteolysis GO:0008915//GO:0008234 lipid-A-disaccharide synthase activity//cysteine-type peptidase activity -- -- KOG2215 Exocyst complex subunit Cluster-8309.45726 BF_2 101.20 5.10 1117 189237923 XP_001810409.1 1254 2.8e-135 PREDICTED: exocyst complex component 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJ43 482 3.8e-47 Exocyst complex component 8 OS=Gallus gallus GN=EXOC8 PE=2 SV=1 PF07578//PF02902 Lipid A Biosynthesis N-terminal domain//Ulp1 protease family, C-terminal catalytic domain GO:0006508//GO:0009245 proteolysis//lipid A biosynthetic process GO:0008915//GO:0008234 lipid-A-disaccharide synthase activity//cysteine-type peptidase activity -- -- KOG2215 Exocyst complex subunit Cluster-8309.45729 BF_2 1204.60 45.61 1392 270001240 EEZ97687.1 703 2.7e-71 hypothetical protein TcasGA2_TC016235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V4U9 521 1.4e-51 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.45730 BF_2 10.35 0.84 800 478250187 ENN70690.1 311 4.5e-26 hypothetical protein YQE_12635, partial [Dendroctonus ponderosae] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 218 1.1e-16 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.45732 BF_2 407.05 9.86 2014 546674618 ERL85967.1 1881 1.0e-207 hypothetical protein D910_03382 [Dendroctonus ponderosae] 612023545 XM_007491044.1 107 2.99698e-46 PREDICTED: Monodelphis domestica ClpB caseinolytic peptidase B homolog (E. coli) (CLPB), transcript variant X4, mRNA K03695 clpB ATP-dependent Clp protease ATP-binding subunit ClpB http://www.genome.jp/dbget-bin/www_bget?ko:K03695 Q60649 1468 3.2e-161 Caseinolytic peptidase B protein homolog OS=Mus musculus GN=Clpb PE=1 SV=1 PF00005//PF00023//PF07726//PF06414//PF00910//PF08477//PF07728//PF13606//PF00158//PF00004//PF06309//PF07724//PF00448 ABC transporter//Ankyrin repeat//ATPase family associated with various cellular activities (AAA)//Zeta toxin//RNA helicase//Ras of Complex, Roc, domain of DAPkinase//AAA domain (dynein-related subfamily)//Ankyrin repeat//Sigma-54 interaction domain//ATPase family associated with various cellular activities (AAA)//Torsin//AAA domain (Cdc48 subfamily)//SRP54-type protein, GTPase domain GO:0007264//GO:0006355//GO:0006614 small GTPase mediated signal transduction//regulation of transcription, DNA-templated//SRP-dependent cotranslational protein targeting to membrane GO:0003724//GO:0005525//GO:0016301//GO:0016887//GO:0005515//GO:0008134//GO:0005524//GO:0003723 RNA helicase activity//GTP binding//kinase activity//ATPase activity//protein binding//transcription factor binding//ATP binding//RNA binding GO:0005667 transcription factor complex KOG1051 Chaperone HSP104 and related ATP-dependent Clp proteases Cluster-8309.45736 BF_2 952.12 28.31 1694 546671664 ERL83880.1 838 7.4e-87 hypothetical protein D910_01160 [Dendroctonus ponderosae]>gi|546671671|gb|ERL83885.1| hypothetical protein D910_01165 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P8Y1 518 3.9e-51 Calcyphosin-like protein OS=Mus musculus GN=Capsl PE=2 SV=4 PF13202//PF13833//PF00036//PF13405//PF13499 EF hand//EF-hand domain pair//EF hand//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.45738 BF_2 125.20 4.48 1455 546671664 ERL83880.1 951 5.0e-100 hypothetical protein D910_01160 [Dendroctonus ponderosae]>gi|546671671|gb|ERL83885.1| hypothetical protein D910_01165 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P8Y1 574 1.1e-57 Calcyphosin-like protein OS=Mus musculus GN=Capsl PE=2 SV=4 PF13202//PF13499//PF13405//PF10591//PF13833//PF00036 EF hand//EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.45742 BF_2 1488.06 9.21 7045 270013942 EFA10390.1 1611 7.2e-176 hypothetical protein TcasGA2_TC012621 [Tribolium castaneum] 642935672 XM_969594.3 364 0 PREDICTED: Tribolium castaneum 26S proteasome non-ATPase regulatory subunit 11 (LOC663555), mRNA K03036 PSMD11, RPN6 26S proteasome regulatory subunit N6 http://www.genome.jp/dbget-bin/www_bget?ko:K03036 Q7KLV9 1341 6.0e-146 26S proteasome non-ATPase regulatory subunit 11 OS=Drosophila melanogaster GN=Rpn6 PE=1 SV=1 PF01399//PF05524//PF05823 PCI domain//PEP-utilising enzyme, N-terminal//Nematode fatty acid retinoid binding protein (Gp-FAR-1) GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.45745 BF_2 215.48 2.45 3971 478256717 ENN76898.1 281 6.7e-22 hypothetical protein YQE_06546, partial [Dendroctonus ponderosae]>gi|478266402|gb|ENN82785.1| hypothetical protein YQE_00848, partial [Dendroctonus ponderosae]>gi|546681300|gb|ERL91414.1| hypothetical protein D910_08746 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45746 BF_2 10.00 0.98 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45752 BF_2 876.73 5.11 7462 478252915 ENN73299.1 1438 8.7e-156 hypothetical protein YQE_10063, partial [Dendroctonus ponderosae]>gi|546681594|gb|ERL91658.1| hypothetical protein D910_08986, partial [Dendroctonus ponderosae] -- -- -- -- -- K16526 AKAP10 A-kinase anchor protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16526 O88845 730 4.5e-75 A-kinase anchor protein 10, mitochondrial OS=Mus musculus GN=Akap10 PE=1 SV=3 PF00002//PF02101 7 transmembrane receptor (Secretin family)//Ocular albinism type 1 protein GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.45753 BF_2 83.40 0.45 8010 478252915 ENN73299.1 1438 9.4e-156 hypothetical protein YQE_10063, partial [Dendroctonus ponderosae]>gi|546681594|gb|ERL91658.1| hypothetical protein D910_08986, partial [Dendroctonus ponderosae] -- -- -- -- -- K16526 AKAP10 A-kinase anchor protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16526 O88845 730 4.8e-75 A-kinase anchor protein 10, mitochondrial OS=Mus musculus GN=Akap10 PE=1 SV=3 PF00002//PF02101//PF01534 7 transmembrane receptor (Secretin family)//Ocular albinism type 1 protein//Frizzled/Smoothened family membrane region GO:0007186//GO:0007166 G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.45756 BF_2 633.27 6.05 4663 642922405 XP_008193143.1 994 1.7e-104 PREDICTED: tetratricopeptide repeat protein 14 isoform X2 [Tribolium castaneum] 642922404 XM_008194921.1 225 1.77649e-111 PREDICTED: Tribolium castaneum tetratricopeptide repeat protein 14 (LOC663177), transcript variant X2, mRNA -- -- -- -- Q9VGU5 596 9.7e-60 Tetratricopeptide repeat protein 14 homolog OS=Drosophila melanogaster GN=CG6621 PE=1 SV=2 PF01080//PF13181//PF11744//PF15741//PF05053//PF13174//PF13371//PF02724//PF09726//PF13374//PF00515//PF13176//PF10486//PF13414 Presenilin//Tetratricopeptide repeat//Aluminium activated malate transporter//Ligand-dependent nuclear receptor-interacting factor 1//Menin//Tetratricopeptide repeat//Tetratricopeptide repeat//CDC45-like protein//Transmembrane protein//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Phosphoinositide 3-kinase gamma adapter protein p101 subunit//TPR repeat GO:0006355//GO:0007165//GO:0015743//GO:0006270 regulation of transcription, DNA-templated//signal transduction//malate transport//DNA replication initiation GO:0046935//GO:0004190//GO:0042974//GO:0005515 1-phosphatidylinositol-3-kinase regulator activity//aspartic-type endopeptidase activity//retinoic acid receptor binding//protein binding GO:0005944//GO:0005634//GO:0016021//GO:0005667 phosphatidylinositol 3-kinase complex, class IB//nucleus//integral component of membrane//transcription factor complex -- -- Cluster-8309.45757 BF_2 1558.78 12.49 5506 642927190 XP_008195173.1 7885 0.0e+00 PREDICTED: DNA-directed RNA polymerase II subunit RPB1 [Tribolium castaneum]>gi|270010112|gb|EFA06560.1| hypothetical protein TcasGA2_TC009471 [Tribolium castaneum] 324120583 AB596930.1 1941 0 Lucidina biplagiata RPB1 mRNA for RNA polymerase II largest subunit, partial cds, isolate: E-19 K03006 RPB1, POLR2A DNA-directed RNA polymerase II subunit RPB1 http://www.genome.jp/dbget-bin/www_bget?ko:K03006 P04052 7075 0.0e+00 DNA-directed RNA polymerase II subunit RPB1 OS=Drosophila melanogaster GN=RpII215 PE=3 SV=4 PF04997//PF04992//PF05001//PF00623//PF04998//PF01381//PF04983//PF05000//PF04990 RNA polymerase Rpb1, domain 1//RNA polymerase Rpb1, domain 6//RNA polymerase Rpb1 C-terminal repeat//RNA polymerase Rpb1, domain 2//RNA polymerase Rpb1, domain 5//Helix-turn-helix//RNA polymerase Rpb1, domain 3//RNA polymerase Rpb1, domain 4//RNA polymerase Rpb1, domain 7 GO:0006206//GO:0006351//GO:0006144//GO:0006366 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//transcription from RNA polymerase II promoter GO:0043565//GO:0003899//GO:0003677 sequence-specific DNA binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005665 nucleolus//DNA-directed RNA polymerase II, core complex KOG0260 RNA polymerase II, large subunit Cluster-8309.45760 BF_2 11.04 0.34 1660 642922794 XP_008193328.1 677 3.4e-68 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 406 3.7e-38 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45762 BF_2 23.75 0.62 1899 642925895 XP_008190722.1 1323 4.8e-143 PREDICTED: uncharacterized protein LOC661054 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 705 9.0e-73 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.45766 BF_2 6.18 0.40 931 642920332 XP_975626.2 404 8.6e-37 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078//PF04048 SWI5-dependent HO expression protein 3//Sec8 exocyst complex component specific domain GO:0051028//GO:0006904//GO:0048309//GO:0015031 mRNA transport//vesicle docking involved in exocytosis//endoplasmic reticulum inheritance//protein transport -- -- GO:0000145 exocyst KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.45767 BF_2 359.74 5.14 3214 642919831 XP_008192086.1 788 8.8e-81 PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919833|ref|XP_008192087.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919835|ref|XP_973145.3| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919837|ref|XP_008192088.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919839|ref|XP_008192090.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919841|ref|XP_008192091.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|270006383|gb|EFA02831.1| sprouty [Tribolium castaneum] -- -- -- -- -- K17383 SPRY2 protein sprouty homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17383 O44783 484 6.5e-47 Protein sprouty OS=Drosophila melanogaster GN=sty PE=1 SV=2 PF05210 Sprouty protein (Spry) GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development -- -- GO:0016020 membrane -- -- Cluster-8309.45768 BF_2 957.96 18.74 2425 91083579 XP_968212.1 2253 8.9e-251 PREDICTED: lysine--tRNA ligase isoform X2 [Tribolium castaneum]>gi|270007824|gb|EFA04272.1| hypothetical protein TcasGA2_TC014562 [Tribolium castaneum] 157106532 XM_001649316.1 196 1.21286e-95 Aedes aegypti AAEL014702-RA mRNA K04567 KARS, lysS lysyl-tRNA synthetase, class II http://www.genome.jp/dbget-bin/www_bget?ko:K04567 P37879 1893 2.0e-210 Lysine--tRNA ligase OS=Cricetulus griseus GN=KARS PE=1 SV=1 PF01409//PF00152//PF17121//PF01336//PF06667 tRNA synthetases class II core domain (F)//tRNA synthetases class II (D, K and N)//Zinc finger, C3HC4 type (RING finger)//OB-fold nucleic acid binding domain//Phage shock protein B GO:0006430//GO:0009271//GO:0009085//GO:0006418//GO:0006355//GO:0043039 lysyl-tRNA aminoacylation//phage shock//lysine biosynthetic process//tRNA aminoacylation for protein translation//regulation of transcription, DNA-templated//tRNA aminoacylation GO:0005524//GO:0000049//GO:0005515//GO:0004824//GO:0003676//GO:0000166//GO:0008270//GO:0004812 ATP binding//tRNA binding//protein binding//lysine-tRNA ligase activity//nucleic acid binding//nucleotide binding//zinc ion binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm KOG1885 Lysyl-tRNA synthetase (class II) Cluster-8309.45769 BF_2 278.61 1.19 10065 546685894 ERL95319.1 1917 3.4e-211 hypothetical protein D910_12585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8MSS1 506 5.7e-49 Protein lava lamp OS=Drosophila melanogaster GN=lva PE=1 SV=2 PF06463//PF11427 Molybdenum Cofactor Synthesis C//Tc3 transposase GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0003677//GO:0051539 DNA binding//4 iron, 4 sulfur cluster binding GO:0019008 molybdopterin synthase complex -- -- Cluster-8309.45772 BF_2 246.66 2.35 4686 642939323 XP_969087.2 928 7.5e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 5.75892e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.2e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01956//PF01588//PF02724 Integral membrane protein DUF106//Putative tRNA binding domain//CDC45-like protein GO:0006270 DNA replication initiation GO:0000049 tRNA binding GO:0016020 membrane KOG2241 tRNA-binding protein Cluster-8309.45774 BF_2 252.02 1.95 5681 642937978 XP_008199153.1 5190 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 76 1.46073e-28 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2907 0.0e+00 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF04310//PF03193//PF00005//PF13304//PF06414//PF11080//PF00448 MukB N-terminal//Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//Protein of unknown function (DUF2622)//SRP54-type protein, GTPase domain GO:0051252//GO:0030261//GO:0007059//GO:0006614 regulation of RNA metabolic process//chromosome condensation//chromosome segregation//SRP-dependent cotranslational protein targeting to membrane GO:0016301//GO:0016887//GO:0005525//GO:0004521//GO:0003924//GO:0003677//GO:0005524 kinase activity//ATPase activity//GTP binding//endoribonuclease activity//GTPase activity//DNA binding//ATP binding GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.45776 BF_2 3.00 0.96 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45777 BF_2 524.52 3.12 7322 91081067 XP_975439.1 3055 0.0e+00 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] 749752310 XM_011140194.1 113 5.09347e-49 PREDICTED: Harpegnathos saltator leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 (LOC105182625), transcript variant X5, mRNA -- -- -- -- Q50L44 311 1.7e-26 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF13895//PF13855//PF00560//PF03526 Immunoglobulin domain//Leucine rich repeat//Leucine Rich Repeat//Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643//GO:0005515 toxic substance binding//protein binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.45778 BF_2 192.00 2.67 3291 642929848 XP_008196000.1 3334 0.0e+00 PREDICTED: alanine--tRNA ligase, mitochondrial [Tribolium castaneum] 599384916 XM_007409341.1 64 3.94659e-22 Melampsora larici-populina 98AG31 hypothetical protein (MELLADRAFT_48072), partial mRNA K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VRJ1 1963 2.1e-218 Alanine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-ala-m PE=2 SV=1 PF07973//PF08718//PF01411 Threonyl and Alanyl tRNA synthetase second additional domain//Glycolipid transfer protein (GLTP)//tRNA synthetases class II (A) GO:0046836//GO:0006531//GO:0006419//GO:0043039//GO:0006522 glycolipid transport//aspartate metabolic process//alanyl-tRNA aminoacylation//tRNA aminoacylation//alanine metabolic process GO:0004813//GO:0005524//GO:0017089//GO:0016876//GO:0051861//GO:0000166 alanine-tRNA ligase activity//ATP binding//glycolipid transporter activity//ligase activity, forming aminoacyl-tRNA and related compounds//glycolipid binding//nucleotide binding GO:0005737 cytoplasm KOG0188 Alanyl-tRNA synthetase Cluster-8309.45780 BF_2 160.58 1.69 4270 91077926 XP_974115.1 1002 1.8e-105 PREDICTED: tropinone reductase 2 [Tribolium castaneum]>gi|270001443|gb|EEZ97890.1| hypothetical protein TcasGA2_TC000272 [Tribolium castaneum] 689542246 LL999048.1 56 1.43746e-17 Strongyloides stercoralis genome assembly S_stercoralis_PV0001 ,scaffold SSTP_scaffold0000001 -- -- -- -- Q9X248 335 1.6e-29 3-oxoacyl-[acyl-carrier-protein] reductase FabG OS=Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099) GN=fabG PE=3 SV=1 PF00106//PF01370//PF07684//PF05889//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NOTCH protein//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0007219//GO:0008152//GO:0007275//GO:0030154//GO:0055114 Notch signaling pathway//metabolic process//multicellular organismal development//cell differentiation//oxidation-reduction process GO:0050662//GO:0003824//GO:0016740//GO:0016491//GO:0000166 coenzyme binding//catalytic activity//transferase activity//oxidoreductase activity//nucleotide binding GO:0016021 integral component of membrane -- -- Cluster-8309.45784 BF_2 631.53 5.74 4893 91090284 XP_971237.1 1565 1.1e-170 PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|642934866|ref|XP_008197841.1| PREDICTED: KH domain-containing protein C56G2.1 [Tribolium castaneum]>gi|270013437|gb|EFA09885.1| hypothetical protein TcasGA2_TC012034 [Tribolium castaneum] -- -- -- -- -- K16518 AKAP1 A-kinase anchor protein 1, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K16518 Q92667 500 1.4e-48 A-kinase anchor protein 1, mitochondrial OS=Homo sapiens GN=AKAP1 PE=1 SV=1 PF00013//PF13014 KH domain//KH domain -- -- GO:0003723 RNA binding -- -- KOG2279 Kinase anchor protein AKAP149, contains KH and Tudor RNA-binding domains Cluster-8309.45786 BF_2 306.36 2.70 5032 642931023 XP_008196183.1 2071 2.3e-229 PREDICTED: probable ribonuclease ZC3H12B isoform X2 [Tribolium castaneum] 642931022 XM_008197961.1 302 3.01177e-154 PREDICTED: Tribolium castaneum probable ribonuclease ZC3H12B (LOC661984), transcript variant X2, mRNA K18668 ZC3H12, MCPIP ribonuclease ZC3H12 http://www.genome.jp/dbget-bin/www_bget?ko:K18668 Q5DTV4 843 2.4e-88 Probable ribonuclease ZC3H12C OS=Mus musculus GN=Zc3h12c PE=2 SV=2 PF07499//PF01769//PF05157//PF00642 RuvA, C-terminal domain//Divalent cation transporter//Type II secretion system (T2SS), protein E, N-terminal domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006810//GO:0006281//GO:0006310//GO:0006812 transport//DNA repair//DNA recombination//cation transport GO:0005524//GO:0009378//GO:0046872//GO:0008324 ATP binding//four-way junction helicase activity//metal ion binding//cation transmembrane transporter activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG3777 Uncharacterized conserved protein Cluster-8309.45787 BF_2 587.00 7.73 3462 546675262 ERL86498.1 3058 0.0e+00 hypothetical protein D910_03902 [Dendroctonus ponderosae] 572263546 XM_006609915.1 337 7.22095e-174 PREDICTED: Apis dorsata protein crooked neck-like (LOC102679096), mRNA K12869 CRN, CRNKL1, CLF1, SYF3 crooked neck http://www.genome.jp/dbget-bin/www_bget?ko:K12869 P17886 2735 6.7e-308 Protein crooked neck OS=Drosophila melanogaster GN=crn PE=2 SV=2 PF02184//PF13374//PF05843//PF13414//PF13174//PF06330 HAT (Half-A-TPR) repeat//Tetratricopeptide repeat//Suppressor of forked protein (Suf)//TPR repeat//Tetratricopeptide repeat//Trichodiene synthase (TRI5) GO:0016114//GO:0016106//GO:0006397//GO:0006396 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process//mRNA processing//RNA processing GO:0005515//GO:0045482 protein binding//trichodiene synthase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1915 Cell cycle control protein (crooked neck) Cluster-8309.45788 BF_2 132.68 1.25 4713 642931023 XP_008196183.1 2086 4.0e-231 PREDICTED: probable ribonuclease ZC3H12B isoform X2 [Tribolium castaneum] 642931022 XM_008197961.1 301 1.01406e-153 PREDICTED: Tribolium castaneum probable ribonuclease ZC3H12B (LOC661984), transcript variant X2, mRNA K18668 ZC3H12, MCPIP ribonuclease ZC3H12 http://www.genome.jp/dbget-bin/www_bget?ko:K18668 Q5DTV4 846 1.0e-88 Probable ribonuclease ZC3H12C OS=Mus musculus GN=Zc3h12c PE=2 SV=2 PF05157//PF07499//PF01769//PF00642 Type II secretion system (T2SS), protein E, N-terminal domain//RuvA, C-terminal domain//Divalent cation transporter//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006810//GO:0006281//GO:0006310//GO:0006812 transport//DNA repair//DNA recombination//cation transport GO:0005524//GO:0008324//GO:0009378//GO:0046872 ATP binding//cation transmembrane transporter activity//four-way junction helicase activity//metal ion binding GO:0005657//GO:0009379 replication fork//Holliday junction helicase complex KOG3777 Uncharacterized conserved protein Cluster-8309.45789 BF_2 509.60 7.15 3267 91078940 XP_973987.1 1536 1.6e-167 PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|642916209|ref|XP_008190931.1| PREDICTED: motile sperm domain-containing protein 2 [Tribolium castaneum]>gi|270003691|gb|EFA00139.1| hypothetical protein TcasGA2_TC002960 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CWP6 582 2.8e-58 Motile sperm domain-containing protein 2 OS=Mus musculus GN=Mospd2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0439 VAMP-associated protein involved in inositol metabolism Cluster-8309.45794 BF_2 174.46 2.37 3368 642923652 XP_971908.2 2365 1.3e-263 PREDICTED: uncharacterized protein LOC660599 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1581 4.2e-174 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00437//PF01443//PF00664//PF13304//PF01926//PF08477//PF04670//PF01580//PF01348//PF04548//PF01637//PF02367//PF06414//PF00005//PF03193 Type II/IV secretion system protein//Viral (Superfamily 1) RNA helicase//ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Gtr1/RagA G protein conserved region//FtsK/SpoIIIE family//Type II intron maturase//AIG1 family//Archaeal ATPase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ABC transporter//Protein of unknown function, DUF258 GO:0007264//GO:0002949//GO:0006810//GO:0055085//GO:0006397 small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification//transport//transmembrane transport//mRNA processing GO:0042626//GO:0016301//GO:0016887//GO:0000166//GO:0005525//GO:0003924//GO:0003677//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//kinase activity//ATPase activity//nucleotide binding//GTP binding//GTPase activity//DNA binding//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.45797 BF_2 292.00 4.09 3277 189235137 XP_001807432.1 2668 9.0e-299 PREDICTED: probable RNA-binding protein 19 [Tribolium castaneum]>gi|270003801|gb|EFA00249.1| hypothetical protein TcasGA2_TC003078 [Tribolium castaneum] -- -- -- -- -- K14787 MRD1, RBM19 multiple RNA-binding domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14787 Q8R3C6 1416 5.6e-155 Probable RNA-binding protein 19 OS=Mus musculus GN=Rbm19 PE=1 SV=1 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif -- -- GO:0003676//GO:1901363//GO:0003723//GO:0097159 nucleic acid binding//heterocyclic compound binding//RNA binding//organic cyclic compound binding -- -- KOG0110 RNA-binding protein (RRM superfamily) Cluster-8309.45799 BF_2 2370.67 18.36 5689 642935331 XP_008197971.1 2924 0.0e+00 PREDICTED: regulator of G-protein signaling 7 isoform X2 [Tribolium castaneum] 642935330 XM_008199749.1 953 0 PREDICTED: Tribolium castaneum regulator of G-protein signaling 7 (LOC656292), transcript variant X2, mRNA K16449 RGS regulator of G-protein signaling http://www.genome.jp/dbget-bin/www_bget?ko:K16449 Q80ZD1 950 1.1e-100 Regulator of G-protein signaling 9 OS=Tamias striatus PE=1 SV=1 PF00631//PF00424//PF00610 GGL domain//REV protein (anti-repression trans-activator protein)//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0006355//GO:0007186//GO:0035556//GO:0007165 regulation of transcription, DNA-templated//G-protein coupled receptor signaling pathway//intracellular signal transduction//signal transduction GO:0004871//GO:0003700 signal transducer activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667//GO:0005834 host cell nucleus//transcription factor complex//heterotrimeric G-protein complex KOG3589 G protein signaling regulators Cluster-8309.4580 BF_2 1.00 9.73 234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45800 BF_2 25.78 0.34 3484 91085219 XP_972532.1 1550 4.2e-169 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270009084|gb|EFA05532.1| hypothetical protein TcasGA2_TC015719 [Tribolium castaneum] -- -- -- -- -- K00108 betA, CHDH choline dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00108 P18172 577 1.2e-57 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF05199 GMC oxidoreductase//GMC oxidoreductase GO:0006066//GO:0006563//GO:0055114//GO:0006544//GO:0006566 alcohol metabolic process//L-serine metabolic process//oxidation-reduction process//glycine metabolic process//threonine metabolic process GO:0016614//GO:0008812//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//choline dehydrogenase activity//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.45802 BF_2 36.62 0.34 4829 91080259 XP_973356.1 2365 1.8e-263 PREDICTED: TBC1 domain family member 23 [Tribolium castaneum]>gi|270005620|gb|EFA02068.1| hypothetical protein TcasGA2_TC007702 [Tribolium castaneum] 641791443 XM_005305637.2 106 2.6098e-45 PREDICTED: Chrysemys picta bellii chaperonin containing TCP1, subunit 4 (delta) (CCT4), mRNA K09496 CCT4 T-complex protein 1 subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K09496 Q9NB32 2088 9.9e-233 T-complex protein 1 subunit delta OS=Ochlerotatus triseriatus PE=2 SV=1 PF00118 TCP-1/cpn60 chaperonin family -- -- GO:0005524 ATP binding GO:0005622 intracellular KOG0358 Chaperonin complex component, TCP-1 delta subunit (CCT4) Cluster-8309.45803 BF_2 855.82 11.33 3446 91076338 XP_971007.1 2127 5.1e-236 PREDICTED: protein TAPT1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VED0 1430 1.4e-156 Protein TAPT1 homolog OS=Drosophila melanogaster GN=CG7218 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2490 Predicted membrane protein Cluster-8309.45804 BF_2 623.47 12.86 2315 642928539 XP_008195366.1 627 3.0e-62 PREDICTED: trypsin-1-like [Tribolium castaneum]>gi|270011007|gb|EFA07455.1| serine protease P94 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 435 2.2e-41 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0003824 serine-type endopeptidase activity//catalytic activity -- -- -- -- Cluster-8309.45805 BF_2 40.04 0.38 4707 270004078 EFA00526.1 412 5.1e-37 hypothetical protein TcasGA2_TC003391 [Tribolium castaneum] 662204498 XM_008477405.1 35 7.48328e-06 PREDICTED: Diaphorina citri uncharacterized LOC103512635 (LOC103512635), mRNA -- -- -- -- -- -- -- -- PF01091 PTN/MK heparin-binding protein family, C-terminal domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0008083 growth factor activity -- -- -- -- Cluster-8309.45806 BF_2 563.96 1.55 15538 642934439 XP_008197663.1 5595 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 642934440 XM_008199442.1 135 6.38333e-61 PREDICTED: Tribolium castaneum nucleosome-remodeling factor subunit NURF301 (LOC100141790), transcript variant X3, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1598 2.1e-175 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00155//PF02178//PF13639//PF12125//PF00439//PF16866//PF00628//PF00202 Aminotransferase class I and II//AT hook motif//Ring finger domain//D domain of beta-TrCP//Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III GO:0009058 biosynthetic process GO:0003677//GO:0008270//GO:0005515//GO:0008483//GO:0030170//GO:0046983 DNA binding//zinc ion binding//protein binding//transaminase activity//pyridoxal phosphate binding//protein dimerization activity -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.45809 BF_2 99.55 6.71 908 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957//PF06209 Synaptobrevin//Cofactor of BRCA1 (COBRA1) GO:0045892//GO:0016192 negative regulation of transcription, DNA-templated//vesicle-mediated transport -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.45810 BF_2 119.53 3.17 1863 828177651 AKK25148.1 438 2.0e-40 chemosensory protein 4 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 251 3.9e-20 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01299//PF00957//PF06209 Lysosome-associated membrane glycoprotein (Lamp)//Synaptobrevin//Cofactor of BRCA1 (COBRA1) GO:0016192//GO:0045892 vesicle-mediated transport//negative regulation of transcription, DNA-templated -- -- GO:0016020//GO:0016021//GO:0005634 membrane//integral component of membrane//nucleus -- -- Cluster-8309.45812 BF_2 354.81 3.79 4204 642922624 XP_008193254.1 3594 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] 642922625 XM_008195033.1 226 4.44933e-112 PREDICTED: Tribolium castaneum uncharacterized LOC659317 (LOC659317), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07291 Methylamine utilisation protein MauE GO:0030416 methylamine metabolic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45814 BF_2 165.10 0.93 7727 642937296 XP_008198775.1 2919 0.0e+00 PREDICTED: uncharacterized protein LOC658848 isoform X3 [Tribolium castaneum] 642937295 XM_008200553.1 210 6.4344e-103 PREDICTED: Tribolium castaneum uncharacterized LOC658848 (LOC658848), transcript variant X3, mRNA -- -- -- -- Q70EL1 831 9.0e-87 Inactive ubiquitin carboxyl-terminal hydrolase 54 OS=Homo sapiens GN=USP54 PE=1 SV=4 PF00126//PF09663 Bacterial regulatory helix-turn-helix protein, lysR family//Amidohydrolase ring-opening protein (Amido_AtzD_TrzD) GO:0006807//GO:0006355 nitrogen compound metabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0016812 transcription factor activity, sequence-specific DNA binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides GO:0005667 transcription factor complex KOG1887 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.45815 BF_2 41.74 1.83 1243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45817 BF_2 290.48 2.39 5371 642928768 XP_008195553.1 4200 0.0e+00 PREDICTED: ATPase, class II, type 9B isoform X2 [Tribolium castaneum] 462389179 APGK01019264.1 69 1.07478e-24 Dendroctonus ponderosae Seq01019274, whole genome shotgun sequence K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 O43861 2973 0.0e+00 Probable phospholipid-transporting ATPase IIB OS=Homo sapiens GN=ATP9B PE=2 SV=4 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0210 P-type ATPase Cluster-8309.45821 BF_2 45.09 0.66 3162 189240526 XP_972038.2 1592 5.1e-174 PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933395|ref|XP_008197398.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933397|ref|XP_008197400.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933399|ref|XP_008197401.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933402|ref|XP_008197402.1| PREDICTED: epsin-1 [Tribolium castaneum] 462340791 APGK01036278.1 94 7.97538e-39 Dendroctonus ponderosae Seq01036288, whole genome shotgun sequence K12471 EPN epsin http://www.genome.jp/dbget-bin/www_bget?ko:K12471 Q9Z1Z3 828 8.2e-87 Epsin-2 OS=Rattus norvegicus GN=Epn2 PE=1 SV=1 PF07651//PF09298//PF00790 ANTH domain//Fumarylacetoacetase N-terminal//VHS domain GO:0006886//GO:0006570//GO:0042207//GO:0009072 intracellular protein transport//tyrosine metabolic process//styrene catabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005543 fumarylacetoacetase activity//phospholipid binding -- -- KOG2056 Equilibrative nucleoside transporter protein Cluster-8309.45822 BF_2 618.91 11.01 2639 189240526 XP_972038.2 1592 4.3e-174 PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933395|ref|XP_008197398.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933397|ref|XP_008197400.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933399|ref|XP_008197401.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933402|ref|XP_008197402.1| PREDICTED: epsin-1 [Tribolium castaneum] 462340791 APGK01036278.1 94 6.64569e-39 Dendroctonus ponderosae Seq01036288, whole genome shotgun sequence K12471 EPN epsin http://www.genome.jp/dbget-bin/www_bget?ko:K12471 Q9Z1Z3 828 6.9e-87 Epsin-2 OS=Rattus norvegicus GN=Epn2 PE=1 SV=1 PF07651//PF00790//PF09298 ANTH domain//VHS domain//Fumarylacetoacetase N-terminal GO:0006886//GO:0006570//GO:0042207//GO:0009072 intracellular protein transport//tyrosine metabolic process//styrene catabolic process//aromatic amino acid family metabolic process GO:0004334//GO:0005543 fumarylacetoacetase activity//phospholipid binding -- -- KOG2056 Equilibrative nucleoside transporter protein Cluster-8309.45823 BF_2 64.00 0.88 3324 189240526 XP_972038.2 1592 5.4e-174 PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933395|ref|XP_008197398.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933397|ref|XP_008197400.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933399|ref|XP_008197401.1| PREDICTED: epsin-1 [Tribolium castaneum]>gi|642933402|ref|XP_008197402.1| PREDICTED: epsin-1 [Tribolium castaneum] 462340791 APGK01036278.1 94 8.38869e-39 Dendroctonus ponderosae Seq01036288, whole genome shotgun sequence K12471 EPN epsin http://www.genome.jp/dbget-bin/www_bget?ko:K12471 Q9Z1Z3 828 8.6e-87 Epsin-2 OS=Rattus norvegicus GN=Epn2 PE=1 SV=1 PF07651//PF09298//PF00790 ANTH domain//Fumarylacetoacetase N-terminal//VHS domain GO:0009072//GO:0042207//GO:0006886//GO:0006570 aromatic amino acid family metabolic process//styrene catabolic process//intracellular protein transport//tyrosine metabolic process GO:0005543//GO:0004334 phospholipid binding//fumarylacetoacetase activity -- -- KOG2056 Equilibrative nucleoside transporter protein Cluster-8309.45825 BF_2 184.66 2.05 4062 270009986 EFA06434.1 1589 1.5e-173 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.9e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF01544//PF02653//PF03359 CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component//Guanylate-kinase-associated protein (GKAP) protein GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.45826 BF_2 166.27 3.60 2221 546673801 ERL85345.1 1439 2.0e-156 hypothetical protein D910_02765 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7SXW3 744 3.2e-77 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.45828 BF_2 20.85 0.58 1803 270015218 EFA11666.1 360 2.1e-31 hypothetical protein TcasGA2_TC008530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW3 162 7.9e-10 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF08163//PF13855 NUC194 domain//Leucine rich repeat GO:0009069//GO:0016310//GO:0006303 serine family amino acid metabolic process//phosphorylation//double-strand break repair via nonhomologous end joining GO:0005515//GO:0004677//GO:0005524//GO:0003677 protein binding//DNA-dependent protein kinase activity//ATP binding//DNA binding GO:0005958//GO:0005634 DNA-dependent protein kinase-DNA ligase 4 complex//nucleus KOG0619 FOG: Leucine rich repeat Cluster-8309.45833 BF_2 2.00 4.66 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45834 BF_2 69.63 0.42 7242 91075968 XP_969381.1 1380 4.5e-149 PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|642910393|ref|XP_008190714.1| PREDICTED: abhydrolase domain-containing protein 8 isoform X1 [Tribolium castaneum]>gi|270014619|gb|EFA11067.1| hypothetical protein TcasGA2_TC004663 [Tribolium castaneum] -- -- -- -- -- K03522 fixB, etfA electron transfer flavoprotein alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03522 P13803 751 1.6e-77 Electron transfer flavoprotein subunit alpha, mitochondrial OS=Rattus norvegicus GN=Etfa PE=1 SV=4 PF07224//PF16987//PF03403//PF00326//PF07819//PF04083//PF12740//PF15453//PF02230//PF06821 Chlorophyllase//KIX domain//Platelet-activating factor acetylhydrolase, isoform II//Prolyl oligopeptidase family//PGAP1-like protein//Partial alpha/beta-hydrolase lipase region//Chlorophyllase enzyme//Protein incorporated later into Tight Junctions//Phospholipase/Carboxylesterase//Serine hydrolase GO:0015996//GO:0006505//GO:0006886//GO:0006355//GO:0046486//GO:0006629//GO:0015994//GO:0016042//GO:0006508 chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport//regulation of transcription, DNA-templated//glycerolipid metabolic process//lipid metabolic process//chlorophyll metabolic process//lipid catabolic process//proteolysis GO:0016787//GO:0003847//GO:0003712//GO:0008236//GO:0016788//GO:0047746 hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//transcription cofactor activity//serine-type peptidase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity GO:0005923//GO:0008247//GO:0005667 bicellular tight junction//1-alkyl-2-acetylglycerophosphocholine esterase complex//transcription factor complex KOG3954 Electron transfer flavoprotein, alpha subunit Cluster-8309.45838 BF_2 112.41 0.78 6290 546677600 ERL88405.1 5090 0.0e+00 hypothetical protein D910_05791 [Dendroctonus ponderosae] -- -- -- -- -- K17601 WDR81 WD repeat-containing protein 81 http://www.genome.jp/dbget-bin/www_bget?ko:K17601 D4A929 968 9.5e-103 WD repeat-containing protein 81 OS=Rattus norvegicus GN=Wdr81 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.45842 BF_2 269.09 1.77 6646 56756172 CAH65679.2 2465 6.3e-275 acetylcholinesterase precursor [Nilaparvata lugens] 642913509 XM_008202822.1 782 0 PREDICTED: Tribolium castaneum acetylcholinesterase 2 (LOC659368), mRNA K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 Q27677 3038 0.0e+00 Acetylcholinesterase OS=Leptinotarsa decemlineata PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG4389 Acetylcholinesterase/Butyrylcholinesterase Cluster-8309.45843 BF_2 9.00 0.85 731 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07926//PF00370 TPR/MLP1/MLP2-like protein//FGGY family of carbohydrate kinases, N-terminal domain GO:0006606//GO:0005975 protein import into nucleus//carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- -- -- Cluster-8309.45844 BF_2 270.56 3.28 3733 759001854 AJP08639.1 1844 3.6e-203 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 436 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1619 1.8e-178 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF03242//PF06293//PF00069 Protein tyrosine kinase//Late embryogenesis abundant protein//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.45846 BF_2 59.31 0.37 7049 91091256 XP_968850.1 1918 1.8e-211 PREDICTED: isocitrate dehydrogenase [NADP] cytoplasmic [Tribolium castaneum]>gi|270013091|gb|EFA09539.1| hypothetical protein TcasGA2_TC011647 [Tribolium castaneum] 757951337 KJ371291.1 374 0 Pogonistes gracilis isolate Pgra1-2 voucher Pgra1-RBINS cytoplasmic NADP+-dependent isocitrate dehydrogenase (IDH1) gene, partial cds K00031 IDH1, IDH2, icd isocitrate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00031 P41562 1730 4.7e-191 Isocitrate dehydrogenase [NADP] cytoplasmic OS=Rattus norvegicus GN=Idh1 PE=1 SV=1 PF01398//PF04117//PF00180 JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Mpv17 / PMP22 family//Isocitrate/isopropylmalate dehydrogenase GO:0006099//GO:0055114//GO:0006749//GO:0006102//GO:0019643 tricarboxylic acid cycle//oxidation-reduction process//glutathione metabolic process//isocitrate metabolic process//reductive tricarboxylic acid cycle GO:0000287//GO:0004450//GO:0005515//GO:0051287//GO:0016616 magnesium ion binding//isocitrate dehydrogenase (NADP+) activity//protein binding//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016021 integral component of membrane KOG1526 NADP-dependent isocitrate dehydrogenase Cluster-8309.45847 BF_2 93.12 2.31 1977 755545949 XP_011242903.1 916 7.8e-96 PREDICTED: zinc finger protein 431-like, partial [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 875 1.8e-92 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF05864//PF13912//PF16622//PF07776//PF00096//PF13465 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.4585 BF_2 11.59 0.43 1408 546674258 ERL85677.1 861 1.3e-89 hypothetical protein D910_03093 [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q55E31 472 7.0e-46 Ras-related protein Rab-32B OS=Dictyostelium discoideum GN=rab32B PE=3 SV=1 PF00071//PF00025//PF08477//PF01926 Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- -- -- Cluster-8309.45850 BF_2 52.57 0.33 6881 675371505 KFM64407.1 682 3.7e-68 PiggyBac transposable element-derived protein 4, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P16425 223 2.5e-16 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF13949//PF00484 ALIX V-shaped domain binding to HIV//Carbonic anhydrase GO:0006807//GO:0006730 nitrogen compound metabolic process//one-carbon metabolic process GO:0005515//GO:0004089//GO:0008270 protein binding//carbonate dehydratase activity//zinc ion binding -- -- -- -- Cluster-8309.45851 BF_2 3.98 0.58 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45852 BF_2 87.00 6.97 809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03920//PF00170//PF13851//PF06005//PF04111//PF02183//PF00225//PF09728//PF07926//PF04136 Groucho/TLE N-terminal Q-rich domain//bZIP transcription factor//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//Autophagy protein Apg6//Homeobox associated leucine zipper//Kinesin motor domain//Myosin-like coiled-coil protein//TPR/MLP1/MLP2-like protein//Sec34-like family GO:0000917//GO:0043093//GO:0048870//GO:0006606//GO:0006355//GO:0007017//GO:0007018//GO:0006886//GO:0006914 barrier septum assembly//FtsZ-dependent cytokinesis//cell motility//protein import into nucleus//regulation of transcription, DNA-templated//microtubule-based process//microtubule-based movement//intracellular protein transport//autophagy GO:0008017//GO:0003777//GO:0005515//GO:0019905//GO:0043565//GO:0003700//GO:0005524 microtubule binding//microtubule motor activity//protein binding//syntaxin binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//ATP binding GO:0016020//GO:0005667//GO:0005874//GO:0005801//GO:0005737//GO:0031514//GO:0045298 membrane//transcription factor complex//microtubule//cis-Golgi network//cytoplasm//motile cilium//tubulin complex -- -- Cluster-8309.45853 BF_2 74.11 1.07 3173 642919263 XP_008191800.1 1439 2.8e-156 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8BGM5 922 1.0e-97 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.45855 BF_2 77.14 1.97 1929 642918534 XP_008191512.1 171 1.9e-09 PREDICTED: titin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45858 BF_2 22.81 1.55 902 642935862 XP_008198202.1 691 4.4e-70 PREDICTED: peroxisomal targeting signal 1 receptor isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q920N5 202 9.1e-15 Peroxisomal targeting signal 1 receptor OS=Cricetulus griseus GN=PEX5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45862 BF_2 43.00 8.00 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45863 BF_2 475.60 1.95 10501 642913929 XP_008201218.1 1980 1.7e-218 PREDICTED: headcase protein [Tribolium castaneum] 642913928 XM_008202996.1 693 0 PREDICTED: Tribolium castaneum headcase protein (LOC664275), mRNA -- -- -- -- Q9N2M8 849 1.0e-88 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 PF02701//PF10403 Dof domain, zinc finger//Rad4 beta-hairpin domain 1 GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3816 Cell differentiation regulator of the Headcase family Cluster-8309.45864 BF_2 49.57 0.32 6697 646719715 KDR21733.1 2722 1.0e-304 Importin-7 [Zootermopsis nevadensis] 558207907 XM_006132981.1 93 6.10938e-38 PREDICTED: Pelodiscus sinensis ubiquitin-conjugating enzyme E2M (UBE2M), mRNA -- -- -- -- O95373 2243 1.5e-250 Importin-7 OS=Homo sapiens GN=IPO7 PE=1 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0015031//GO:0006464 protein transport//cellular protein modification process GO:0005515 protein binding -- -- KOG1991 Nuclear transport receptor RANBP7/RANBP8 (importin beta superfamily) Cluster-8309.45865 BF_2 460.81 3.22 6268 642929348 XP_008195797.1 4436 0.0e+00 PREDICTED: kinesin-like protein KIF16B [Tribolium castaneum] -- -- -- -- -- K17916 KIF16B, SNX23 kinesin family member 16B http://www.genome.jp/dbget-bin/www_bget?ko:K17916 B1AVY7 1650 7.9e-182 Kinesin-like protein KIF16B OS=Mus musculus GN=Kif16b PE=1 SV=1 PF00787//PF00498//PF00225 PX domain//FHA domain//Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0035091//GO:0005515//GO:0003777//GO:0008017 ATP binding//phosphatidylinositol binding//protein binding//microtubule motor activity//microtubule binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0245 Kinesin-like protein Cluster-8309.45866 BF_2 67.21 3.01 1221 642912944 XP_008201318.1 552 7.8e-54 PREDICTED: antichymotrypsin-2-like isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 382 1.6e-35 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45871 BF_2 429.00 4.16 4600 546684887 ERL94469.1 2704 8.5e-303 hypothetical protein D910_11746 [Dendroctonus ponderosae] -- -- -- -- -- K10866 RAD50 DNA repair protein RAD50 http://www.genome.jp/dbget-bin/www_bget?ko:K10866 Q9W252 1533 2.1e-168 DNA repair protein RAD50 OS=Drosophila melanogaster GN=rad50 PE=2 SV=4 PF13304//PF16331//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//TolA binding protein trimerisation//ABC transporter GO:0070206 protein trimerization GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- KOG0962 DNA repair protein RAD50, ABC-type ATPase/SMC superfamily Cluster-8309.45872 BF_2 779.15 6.08 5651 189235813 XP_971989.2 2629 5.2e-294 PREDICTED: probable cytosolic oligopeptidase A [Tribolium castaneum] 689005257 LL516414.1 39 5.37581e-08 Onchocerca ochengi genome assembly O_ochengi_Ngaoundere ,scaffold OOCN_contig0000027 K01409 KAE1, tsaD, QRI7 N6-L-threonylcarbamoyladenine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01409 Q7SYR1 1314 6.5e-143 Probable tRNA N6-adenosine threonylcarbamoyltransferase OS=Xenopus laevis GN=osgep PE=2 SV=1 PF02543//PF01432 Carbamoyltransferase N-terminus//Peptidase family M3 GO:0006508//GO:0009058 proteolysis//biosynthetic process GO:0004222//GO:0003824 metalloendopeptidase activity//catalytic activity -- -- KOG2708 Predicted metalloprotease with chaperone activity (RNAse H/HSP70 fold) Cluster-8309.45874 BF_2 4.00 1.40 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45875 BF_2 77.00 3.56 1192 308482644 XP_003103525.1 145 1.2e-06 CRE-CLEC-199 protein [Caenorhabditis remanei]>gi|308259946|gb|EFP03899.1| CRE-CLEC-199 protein [Caenorhabditis remanei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45877 BF_2 291.02 3.91 3399 642919831 XP_008192086.1 788 9.3e-81 PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919833|ref|XP_008192087.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919835|ref|XP_973145.3| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919837|ref|XP_008192088.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919839|ref|XP_008192090.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|642919841|ref|XP_008192091.1| PREDICTED: protein sprouty [Tribolium castaneum]>gi|270006383|gb|EFA02831.1| sprouty [Tribolium castaneum] -- -- -- -- -- K17383 SPRY2 protein sprouty homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17383 O44783 484 6.8e-47 Protein sprouty OS=Drosophila melanogaster GN=sty PE=1 SV=2 PF05210 Sprouty protein (Spry) GO:0007275//GO:0009966 multicellular organismal development//regulation of signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.45878 BF_2 53.85 0.56 4295 91090558 XP_971487.1 1781 8.5e-196 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 828217611 XM_002154671.3 60 8.64104e-20 PREDICTED: Hydra vulgaris transcription elongation factor 1 homolog (LOC100207595), mRNA K03241 EIF2B3 translation initiation factor eIF-2B subunit gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03241 A5PJI7 711 4.1e-73 Translation initiation factor eIF-2B subunit gamma OS=Bos taurus GN=EIF2B3 PE=2 SV=1 PF00483//PF07959//PF01128 Nucleotidyl transferase//L-fucokinase//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0050518//GO:0016779//GO:0016772 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity//transferase activity, transferring phosphorus-containing groups -- -- KOG1462 Translation initiation factor 2B, gamma subunit (eIF-2Bgamma/GCD1) Cluster-8309.45880 BF_2 110.11 1.12 4397 91090558 XP_971487.1 1781 8.7e-196 PREDICTED: translation initiation factor eIF-2B subunit gamma [Tribolium castaneum]>gi|270013887|gb|EFA10335.1| hypothetical protein TcasGA2_TC012553 [Tribolium castaneum] 751447204 XM_011179427.1 197 6.15126e-96 PREDICTED: Bactrocera cucurbitae elongation of very long chain fatty acids protein AAEL008004 (LOC105209165), transcript variant X2, mRNA K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 996 3.8e-106 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01128//PF01151//PF07959//PF00483 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase//GNS1/SUR4 family//L-fucokinase//Nucleotidyl transferase GO:0008299//GO:0009058//GO:0006694 isoprenoid biosynthetic process//biosynthetic process//steroid biosynthetic process GO:0016772//GO:0050518//GO:0016779 transferase activity, transferring phosphorus-containing groups//2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity//nucleotidyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.45884 BF_2 27.00 7.77 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45885 BF_2 7.40 3.83 365 -- -- -- -- -- 462329210 APGK01040426.1 36 1.48024e-07 Dendroctonus ponderosae Seq01040436, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.45886 BF_2 10.60 3.70 406 -- -- -- -- -- 462329210 APGK01040426.1 36 1.66304e-07 Dendroctonus ponderosae Seq01040436, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.45888 BF_2 2257.44 23.28 4344 646696935 KDR08899.1 1285 2.8e-138 Beta-amyloid-like protein, partial [Zootermopsis nevadensis] 462380259 APGK01022394.1 40 1.14676e-08 Dendroctonus ponderosae Seq01022404, whole genome shotgun sequence K04520 APP amyloid beta A4 protein http://www.genome.jp/dbget-bin/www_bget?ko:K04520 P14599 928 2.9e-98 Beta-amyloid-like protein OS=Drosophila melanogaster GN=Appl PE=1 SV=2 PF12924//PF02177 Copper-binding of amyloid precursor, CuBD//Amyloid A4 N-terminal heparin-binding -- -- GO:0046914//GO:0008201 transition metal ion binding//heparin binding -- -- KOG3540 Beta amyloid precursor protein Cluster-8309.45894 BF_2 30.74 0.73 2055 270014491 EFA10939.1 774 2.4e-79 hypothetical protein TcasGA2_TC001770 [Tribolium castaneum] 751473836 XM_011193984.1 53 3.19172e-16 PREDICTED: Bactrocera cucurbitae endochitinase (LOC105218422), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 P36362 522 1.6e-51 Endochitinase OS=Manduca sexta PE=2 SV=1 PF00704//PF01607 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.45900 BF_2 98.54 0.55 7824 642914403 XP_008201481.1 2794 0.0e+00 PREDICTED: TELO2-interacting protein 1 homolog [Tribolium castaneum] 780665329 XM_011695591.1 124 4.17915e-55 PREDICTED: Wasmannia auropunctata uncharacterized LOC105453540 (LOC105453540), mRNA -- -- -- -- Q3ZCX4 649 1.2e-65 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF13465//PF08880//PF00096//PF02985//PF08064 Zinc-finger double domain//QLQ//Zinc finger, C2H2 type//HEAT repeat//UME (NUC010) domain GO:0016310//GO:0009069//GO:0006355 phosphorylation//serine family amino acid metabolic process//regulation of transcription, DNA-templated GO:0005515//GO:0005524//GO:0046872//GO:0004674 protein binding//ATP binding//metal ion binding//protein serine/threonine kinase activity GO:0005634 nucleus -- -- Cluster-8309.45903 BF_2 764.56 5.00 6683 642928510 XP_008193821.1 3443 0.0e+00 PREDICTED: multiple C2 and transmembrane domain-containing protein 1 isoform X2 [Tribolium castaneum] 755894366 XM_011297040.1 39 6.36089e-08 PREDICTED: Musca domestica multiple C2 and transmembrane domain-containing protein 1 (LOC101898395), transcript variant X1, mRNA -- -- -- -- Q6DN14 1246 5.9e-135 Multiple C2 and transmembrane domain-containing protein 1 OS=Homo sapiens GN=MCTP1 PE=2 SV=2 PF00606//PF02542//PF00168 Herpesvirus Glycoprotein B//YgbB family//C2 domain GO:0016114 terpenoid biosynthetic process GO:0005515//GO:0008685 protein binding//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity GO:0016020 membrane KOG1030 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.45906 BF_2 280.54 2.95 4261 642923667 XP_008193834.1 4119 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15439 2437 3.0e-273 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF02367//PF06414//PF00006//PF03205//PF03193//PF03266//PF00005//PF13304//PF01926//PF01443//PF00664//PF08477 NB-ARC domain//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//ATP synthase alpha/beta family, nucleotide-binding domain//Molybdopterin guanine dinucleotide synthesis protein B//Protein of unknown function, DUF258//NTPase//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Viral (Superfamily 1) RNA helicase//ABC transporter transmembrane region//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0006777//GO:0002949//GO:0006810//GO:0055085 small GTPase mediated signal transduction//Mo-molybdopterin cofactor biosynthetic process//tRNA threonylcarbamoyladenosine modification//transport//transmembrane transport GO:0042626//GO:0016887//GO:0016301//GO:0005525//GO:0003924//GO:0043531//GO:0098519//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//GTP binding//GTPase activity//ADP binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.45908 BF_2 36.22 0.43 3789 270009834 EFA06282.1 2409 1.1e-268 hypothetical protein TcasGA2_TC009148 [Tribolium castaneum] -- -- -- -- -- K12600 SKI3, TTC37 superkiller protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12600 Q6PGP7 940 1.0e-99 Tetratricopeptide repeat protein 37 OS=Homo sapiens GN=TTC37 PE=1 SV=1 PF13174//PF13181//PF12513//PF13414//PF13176//PF00515//PF13374//PF13371 Tetratricopeptide repeat//Tetratricopeptide repeat//Mitochondrial degradasome RNA helicase subunit C terminal//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0016817//GO:0005515 hydrolase activity, acting on acid anhydrides//protein binding -- -- KOG1127 TPR repeat-containing protein Cluster-8309.4591 BF_2 55.00 1.48 1839 478256216 ENN76410.1 208 9.1e-14 hypothetical protein YQE_07071, partial [Dendroctonus ponderosae]>gi|546684462|gb|ERL94101.1| hypothetical protein D910_11383 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45910 BF_2 301.54 3.56 3826 546683595 ERL93390.1 1233 2.6e-132 hypothetical protein D910_10682 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45911 BF_2 41.61 7.84 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45912 BF_2 87.91 0.93 4230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05737 Collagen binding domain -- -- GO:0005518 collagen binding GO:0005581 collagen trimer -- -- Cluster-8309.45913 BF_2 292.00 3.60 3679 546670890 ERL83460.1 943 1.1e-98 hypothetical protein D910_00452 [Dendroctonus ponderosae]>gi|546677255|gb|ERL88124.1| hypothetical protein D910_05512 [Dendroctonus ponderosae]>gi|546678640|gb|ERL89222.1| hypothetical protein D910_06596 [Dendroctonus ponderosae] -- -- -- -- -- K07928 RAB40 Ras-related protein Rab-40 http://www.genome.jp/dbget-bin/www_bget?ko:K07928 Q8VHQ4 748 1.8e-77 Ras-related protein Rab-40C OS=Mus musculus GN=Rab40c PE=2 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.45917 BF_2 115.00 2.35 2333 270016078 EFA12526.1 1195 4.1e-128 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 793 6.9e-83 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00665//PF10371 Integrase core domain//Domain of unknown function GO:0055114//GO:0015074 oxidation-reduction process//DNA integration GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors -- -- -- -- Cluster-8309.45922 BF_2 162.13 1.81 4043 546678692 ERL89260.1 3267 0.0e+00 hypothetical protein D910_06633, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15145 1260 8.5e-137 Aminopeptidase N OS=Sus scrofa GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.45923 BF_2 428.59 9.57 2160 571330962 AHF27413.1 1329 1.1e-143 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A5LGM7 437 1.2e-41 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.45928 BF_2 720.86 8.17 3978 642913546 XP_008201056.1 1646 3.5e-180 PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913548|ref|XP_008201057.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913550|ref|XP_008201058.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum]>gi|642913552|ref|XP_008201059.1| PREDICTED: organic cation transporter protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 645 1.7e-65 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.45929 BF_2 1128.31 12.39 4098 642924614 XP_008194364.1 2671 5.1e-299 PREDICTED: uncharacterized protein LOC663601 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17335 NFAT5 nuclear factor of activated T-cells 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17335 Q9WV30 701 5.7e-72 Nuclear factor of activated T-cells 5 OS=Mus musculus GN=Nfat5 PE=1 SV=2 PF01833//PF00554 IPT/TIG domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.45930 BF_2 150.00 1.31 5061 642917976 XP_008198967.1 3341 0.0e+00 PREDICTED: follistatin-related protein 5-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BFR2 1162 2.5e-125 Follistatin-related protein 5 OS=Mus musculus GN=Fstl5 PE=2 SV=1 PF10591//PF13833//PF13405//PF13499//PF00050//PF00036//PF07648//PF13895//PF13202 Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Kazal-type serine protease inhibitor domain//EF hand//Kazal-type serine protease inhibitor domain//Immunoglobulin domain//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.45936 BF_2 4.56 0.42 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45937 BF_2 352.79 6.31 2627 642910319 XP_969877.2 2468 1.1e-275 PREDICTED: uridine-cytidine kinase-like 1 [Tribolium castaneum] 602627952 XM_007420856.1 35 4.15387e-06 PREDICTED: Python bivittatus uridine-cytidine kinase-like 1-like (LOC103062425), mRNA K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q91YL3 1454 1.8e-159 Uridine-cytidine kinase-like 1 OS=Mus musculus GN=Uckl1 PE=2 SV=1 PF02224//PF00485//PF01583//PF01121//PF06414//PF03205//PF07931 Cytidylate kinase//Phosphoribulokinase / Uridine kinase family//Adenylylsulphate kinase//Dephospho-CoA kinase//Zeta toxin//Molybdopterin guanine dinucleotide synthesis protein B//Chloramphenicol phosphotransferase-like protein GO:0015940//GO:0008152//GO:0000103//GO:0006139//GO:0006144//GO:0006777//GO:0006206//GO:0015937 pantothenate biosynthetic process//metabolic process//sulfate assimilation//nucleobase-containing compound metabolic process//purine nucleobase metabolic process//Mo-molybdopterin cofactor biosynthetic process//pyrimidine nucleobase metabolic process//coenzyme A biosynthetic process GO:0016740//GO:0005524//GO:0004020//GO:0004127//GO:0016301//GO:0005525//GO:0004140 transferase activity//ATP binding//adenylylsulfate kinase activity//cytidylate kinase activity//kinase activity//GTP binding//dephospho-CoA kinase activity -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.45938 BF_2 37.43 0.58 2978 91093871 XP_967859.1 963 4.2e-101 PREDICTED: OTU domain-containing protein 5-A [Tribolium castaneum]>gi|270014527|gb|EFA10975.1| hypothetical protein TcasGA2_TC004141 [Tribolium castaneum] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 388 8.1e-36 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.45939 BF_2 168.26 3.12 2541 91087799 XP_967345.1 3115 0.0e+00 PREDICTED: threonine--tRNA ligase, cytoplasmic isoform X2 [Tribolium castaneum] 572269851 XM_006612875.1 387 0 PREDICTED: Apis dorsata threonine--tRNA ligase, cytoplasmic-like (LOC102672191), transcript variant X2, mRNA K01868 TARS, thrS threonyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01868 Q3ZBV8 2707 8.7e-305 Threonine--tRNA ligase, cytoplasmic OS=Bos taurus GN=TARS PE=2 SV=1 PF00587//PF07973 tRNA synthetase class II core domain (G, H, P, S and T)//Threonyl and Alanyl tRNA synthetase second additional domain GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0000166//GO:0005524//GO:0004812//GO:0016876 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity//ligase activity, forming aminoacyl-tRNA and related compounds -- -- KOG1637 Threonyl-tRNA synthetase Cluster-8309.45940 BF_2 34.49 1.03 1686 642925227 XP_008194475.1 693 4.8e-70 PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum]>gi|642925229|ref|XP_008194476.1| PREDICTED: zinc finger matrin-type protein 4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9HA38 178 1.0e-11 Zinc finger matrin-type protein 3 OS=Homo sapiens GN=ZMAT3 PE=1 SV=1 PF04988//PF06220 A-kinase anchoring protein 95 (AKAP95)//U1 zinc finger -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.45941 BF_2 137.03 2.51 2575 817061558 XP_012252386.1 254 5.9e-19 PREDICTED: collagen alpha-3(IX) chain-like [Athalia rosae] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 Q07092 197 9.9e-14 Collagen alpha-1(XVI) chain OS=Homo sapiens GN=COL16A1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.45942 BF_2 1590.00 16.26 4378 332374982 AEE62632.1 800 4.9e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13800 CMPK1, UMPK UMP-CMP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13800 Q29561 644 2.5e-65 UMP-CMP kinase OS=Sus scrofa GN=CMPK1 PE=1 SV=1 PF00910//PF06414 RNA helicase//Zeta toxin -- -- GO:0003724//GO:0016301//GO:0005524//GO:0003723 RNA helicase activity//kinase activity//ATP binding//RNA binding -- -- KOG3079 Uridylate kinase/adenylate kinase Cluster-8309.45944 BF_2 5.00 6.45 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45945 BF_2 21.50 0.96 1222 270011108 EFA07556.1 666 4.7e-67 doublesex [Tribolium castaneum] 642928399 XR_511419.1 167 7.95927e-80 PREDICTED: Tribolium castaneum male-specific doublesex isoform m (LOC660453), transcript variant X2, misc_RNA K19488 DMRT1 doublesex- and mab-3-related transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19488 P23023 260 2.3e-21 Protein doublesex OS=Drosophila melanogaster GN=dsx PE=1 SV=1 PF00751 DM DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding -- -- KOG3815 Transcription factor Doublesex Cluster-8309.45946 BF_2 111.00 3.39 1658 751457144 XP_011183174.1 1497 2.8e-163 PREDICTED: protein will die slowly [Bactrocera cucurbitae] 585715269 XM_006825240.1 164 5.06328e-78 PREDICTED: Saccoglossus kowalevskii protein will die slowly-like (LOC100375790), mRNA K14963 WDR5, SWD3, CPS30 COMPASS component SWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K14963 Q9V3J8 1450 3.2e-159 Protein will die slowly OS=Drosophila melanogaster GN=wds PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0266 WD40 repeat-containing protein Cluster-8309.45947 BF_2 3.84 0.75 502 642912880 XP_971262.2 395 5.1e-36 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45948 BF_2 163.00 3.62 2172 642912880 XP_971262.2 1272 4.5e-137 PREDICTED: dentin sialophosphoprotein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45949 BF_2 25.29 1.22 1155 270012481 EFA08929.1 901 2.5e-94 hypothetical protein TcasGA2_TC006636 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 576 5.0e-58 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.45950 BF_2 229.57 11.37 1132 478257458 ENN77614.1 1202 3.1e-129 hypothetical protein YQE_05909, partial [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 767 3.5e-80 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.45952 BF_2 120.69 7.65 947 642937660 XP_008198889.1 727 3.1e-74 PREDICTED: tetraspanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17353 TSPAN18 tetraspanin-18 http://www.genome.jp/dbget-bin/www_bget?ko:K17353 Q96SJ8 233 2.4e-18 Tetraspanin-18 OS=Homo sapiens GN=TSPAN18 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.45954 BF_2 24.35 0.43 2680 478251030 ENN71511.1 446 3.3e-41 hypothetical protein YQE_11804, partial [Dendroctonus ponderosae]>gi|546679470|gb|ERL89934.1| hypothetical protein D910_07293 [Dendroctonus ponderosae] -- -- -- -- -- K16815 PNPLA8 calcium-independent phospholipase A2-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16815 Q9NP80 319 7.3e-28 Calcium-independent phospholipase A2-gamma OS=Homo sapiens GN=PNPLA8 PE=1 SV=1 PF01734 Patatin-like phospholipase GO:0006629 lipid metabolic process -- -- -- -- KOG0513 Ca2+-independent phospholipase A2 Cluster-8309.45958 BF_2 11.00 76.74 243 642918497 XP_972472.3 148 1.1e-07 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X1 [Tribolium castaneum]>gi|270004628|gb|EFA01076.1| hypothetical protein TcasGA2_TC003997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.45959 BF_2 7.12 2.41 410 642918497 XP_972472.3 134 7.7e-06 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X1 [Tribolium castaneum]>gi|270004628|gb|EFA01076.1| hypothetical protein TcasGA2_TC003997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45960 BF_2 283.43 3.03 4203 642918499 XP_008191499.1 263 8.7e-20 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P298 133 4.3e-06 HIG1 domain family member 1B OS=Homo sapiens GN=HIGD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45961 BF_2 211.89 1.21 7597 642918499 XP_008191499.1 263 1.6e-19 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P298 133 7.7e-06 HIG1 domain family member 1B OS=Homo sapiens GN=HIGD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45962 BF_2 205.68 1.17 7624 642918499 XP_008191499.1 263 1.6e-19 PREDICTED: HIG1 domain family member 1A, mitochondrial-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P298 133 7.7e-06 HIG1 domain family member 1B OS=Homo sapiens GN=HIGD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.45964 BF_2 188.19 2.74 3163 189239405 XP_001813943.1 2912 0.0e+00 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] 637379439 XM_008125298.1 41 2.31435e-09 PREDICTED: Anolis carolinensis nuclear export mediator factor NEMF-like (LOC103282578), mRNA -- -- -- -- O60524 1933 6.1e-215 Nuclear export mediator factor NEMF OS=Homo sapiens GN=NEMF PE=1 SV=4 PF08052 PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process -- -- -- -- KOG2030 Predicted RNA-binding protein Cluster-8309.45965 BF_2 1078.57 4.89 9510 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 6.17089e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF00005//PF01399//PF00400//PF03193//PF01018//PF01411//PF02272//PF00493//PF01580//PF00071//PF01926//PF07973//PF01343//PF00025//PF02421 ABC transporter//PCI domain//WD domain, G-beta repeat//Protein of unknown function, DUF258//GTP1/OBG//tRNA synthetases class II (A)//DHHA1 domain//MCM2/3/5 family//FtsK/SpoIIIE family//Ras family//50S ribosome-binding GTPase//Threonyl and Alanyl tRNA synthetase second additional domain//Peptidase family S49//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0043039//GO:0007264//GO:0006413//GO:0006508//GO:0006522//GO:0006446//GO:0006531//GO:0006419//GO:0015684//GO:0006260 tRNA aminoacylation//small GTPase mediated signal transduction//translational initiation//proteolysis//alanine metabolic process//regulation of translational initiation//aspartate metabolic process//alanyl-tRNA aminoacylation//ferrous iron transport//DNA replication GO:0003676//GO:0005525//GO:0005515//GO:0004813//GO:0003677//GO:0015093//GO:0016876//GO:0008233//GO:0016887//GO:0000166//GO:0003924//GO:0003743//GO:0005524 nucleic acid binding//GTP binding//protein binding//alanine-tRNA ligase activity//DNA binding//ferrous iron transmembrane transporter activity//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//ATPase activity//nucleotide binding//GTPase activity//translation initiation factor activity//ATP binding GO:0005737//GO:0005840//GO:0016021 cytoplasm//ribosome//integral component of membrane KOG0188 Alanyl-tRNA synthetase Cluster-8309.45966 BF_2 183.10 4.22 2103 642915190 XP_008190511.1 1436 4.2e-156 PREDICTED: protein phosphatase 1 regulatory subunit 12B-like isoform X1 [Tribolium castaneum] 242023035 XM_002431897.1 50 1.52025e-14 Pediculus humanus corporis protein phosphatase 1 regulatory subunit 12B, putative, mRNA K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q90623 953 1.8e-101 Protein phosphatase 1 regulatory subunit 12A OS=Gallus gallus GN=PPP1R12A PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.45969 BF_2 1.00 0.54 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45970 BF_2 12.00 0.53 1239 861605932 KMQ84424.1 265 1.5e-20 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45971 BF_2 87.00 3.01 1498 642938802 XP_008199892.1 628 1.5e-62 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 466 3.7e-45 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.45972 BF_2 209.39 2.08 4495 642912808 XP_008201260.1 1904 4.8e-210 PREDICTED: neurogenic protein mastermind-like, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21519 206 1.6e-14 Neurogenic protein mastermind OS=Drosophila melanogaster GN=mam PE=2 SV=2 PF09596 MamL-1 domain GO:0007219//GO:0045944 Notch signaling pathway//positive regulation of transcription from RNA polymerase II promoter GO:0003713 transcription coactivator activity GO:0016607//GO:0005667 nuclear speck//transcription factor complex -- -- Cluster-8309.45974 BF_2 132.99 0.87 6708 642940098 XP_008192969.1 1320 3.8e-142 PREDICTED: excitatory amino acid transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 Q10901 652 4.5e-66 Excitatory amino acid transporter OS=Caenorhabditis elegans GN=glt-1 PE=1 SV=2 PF00375//PF01585 Sodium:dicarboxylate symporter family//G-patch domain GO:0006812//GO:0006835//GO:0006820 cation transport//dicarboxylic acid transport//anion transport GO:0003676//GO:0017153 nucleic acid binding//sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.45975 BF_2 86.55 0.57 6661 642940098 XP_008192969.1 1251 3.8e-134 PREDICTED: excitatory amino acid transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 Q10901 602 2.8e-60 Excitatory amino acid transporter OS=Caenorhabditis elegans GN=glt-1 PE=1 SV=2 PF00375//PF01585 Sodium:dicarboxylate symporter family//G-patch domain GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153//GO:0003676 sodium:dicarboxylate symporter activity//nucleic acid binding GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.45977 BF_2 185.46 2.33 3614 642939887 XP_008200200.1 3339 0.0e+00 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 643 2.7e-65 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF08236//PF06152//PF01442//PF03127 SRI (Set2 Rpb1 interacting) domain//Phage minor capsid protein 2//Apolipoprotein A1/A4/E domain//GAT domain GO:0006869//GO:0006886//GO:0034968//GO:0042157//GO:0006554//GO:0006355//GO:0006479 lipid transport//intracellular protein transport//histone lysine methylation//lipoprotein metabolic process//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005198//GO:0008289//GO:0018024 structural molecule activity//lipid binding//histone-lysine N-methyltransferase activity GO:0019028//GO:0005576//GO:0005622//GO:0005694 viral capsid//extracellular region//intracellular//chromosome KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.45978 BF_2 18.00 18.18 318 -- -- -- -- -- 225543475 NM_001145913.1 55 3.48335e-18 Tribolium castaneum ventral vein lacking (Vvl), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.45979 BF_2 445.94 3.57 5508 546675238 ERL86474.1 1956 5.5e-216 hypothetical protein D910_03880 [Dendroctonus ponderosae] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q54G06 923 1.4e-97 Xaa-Pro aminopeptidase 1 OS=Dictyostelium discoideum GN=xpnpep1 PE=3 SV=1 PF01321//PF01398//PF04961//PF02723//PF10278 Creatinase/Prolidase N-terminal domain//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//Non-structural protein NS3/Small envelope protein E//Mediator of RNA pol II transcription subunit 19 GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0003824//GO:0001104//GO:0016787//GO:0005515 catalytic activity//RNA polymerase II transcription cofactor activity//hydrolase activity//protein binding GO:0016020//GO:0016592 membrane//mediator complex KOG2413 Xaa-Pro aminopeptidase Cluster-8309.45981 BF_2 694.64 4.76 6398 642923192 XP_008193649.1 974 4.8e-102 PREDICTED: MFS-type transporter SLC18B1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3Z5L6 368 3.6e-33 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF07690//PF05529//PF17095 Major Facilitator Superfamily//B-cell receptor-associated protein 31-like//Spectrin-binding region of Ca2+-Calmodulin GO:0006886//GO:0055085//GO:0031175 intracellular protein transport//transmembrane transport//neuron projection development GO:0030507//GO:0005516 spectrin binding//calmodulin binding GO:0005783//GO:0016021//GO:0008091 endoplasmic reticulum//integral component of membrane//spectrin KOG3764 Vesicular amine transporter Cluster-8309.45987 BF_2 79.45 0.65 5403 390362249 XP_001190749.2 1582 1.3e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 3.0e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00906//PF01637//PF13606//PF00866//PF00023 Hepatitis core antigen//Archaeal ATPase//Ankyrin repeat//Ring hydroxylating beta subunit//Ankyrin repeat GO:0009405//GO:0055114//GO:0006725 pathogenesis//oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824//GO:0005524//GO:0005198//GO:0005515 catalytic activity//ATP binding//structural molecule activity//protein binding -- -- -- -- Cluster-8309.45990 BF_2 346.37 7.26 2283 642929118 XP_008195696.1 834 2.9e-86 PREDICTED: uncharacterized protein LOC100142378 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42891 537 3.3e-53 Endothelin-converting enzyme 1 OS=Bos taurus GN=ECE1 PE=1 SV=2 PF01431//PF05649 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.45993 BF_2 883.00 7.21 5409 546684088 ERL93807.1 1248 6.8e-134 hypothetical protein D910_11093 [Dendroctonus ponderosae] -- -- -- -- -- K06627 CCNA cyclin A http://www.genome.jp/dbget-bin/www_bget?ko:K06627 P14785 768 1.3e-79 G2/mitotic-specific cyclin-A OS=Drosophila melanogaster GN=CycA PE=1 SV=3 PF05461//PF04108//PF02984//PF00210//PF08336 Apolipoprotein L//Autophagy protein Apg17//Cyclin, C-terminal domain//Ferritin-like domain//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region GO:0006560//GO:0006869//GO:0006914//GO:0042157//GO:0018401//GO:0006525//GO:0006879//GO:0055114 proline metabolic process//lipid transport//autophagy//lipoprotein metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//cellular iron ion homeostasis//oxidation-reduction process GO:0016702//GO:0008289//GO:0004656//GO:0008199 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//lipid binding//procollagen-proline 4-dioxygenase activity//ferric iron binding GO:0005783//GO:0005634//GO:0005576 endoplasmic reticulum//nucleus//extracellular region KOG0654 G2/Mitotic-specific cyclin A Cluster-8309.45997 BF_2 124.27 1.71 3334 642929686 XP_008195936.1 1180 3.2e-126 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] 462360465 APGK01029384.1 79 1.83429e-30 Dendroctonus ponderosae Seq01029394, whole genome shotgun sequence K06064 HAIRLESS hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06064 Q02308 257 1.4e-20 Protein hairless OS=Drosophila melanogaster GN=H PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46 BF_2 2.00 0.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.460 BF_2 5.40 0.33 981 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4600 BF_2 3.00 2.26 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07488 Glycosyl hydrolase family 67 middle domain GO:0045493//GO:0005975 xylan catabolic process//carbohydrate metabolic process GO:0046559 alpha-glucuronidase activity GO:0005576 extracellular region -- -- Cluster-8309.46000 BF_2 67.71 0.89 3467 332374952 AEE62617.1 516 3.3e-49 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CW42 275 1.2e-22 Mitochondrial amidoxime-reducing component 1 OS=Mus musculus GN=Marc1 PE=1 SV=2 PF03473 MOSC domain -- -- GO:0003824//GO:0030151//GO:0030170 catalytic activity//molybdenum ion binding//pyridoxal phosphate binding -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.46001 BF_2 1258.13 16.15 3547 649572315 NP_001280527.1 2820 0.0e+00 lethal(2) giant larvae protein homolog 1 [Tribolium castaneum]>gi|642930673|ref|XP_008199983.1| PREDICTED: lethal(2) giant larvae protein homolog 1 isoform X1 [Tribolium castaneum]>gi|270012677|gb|EFA09125.1| hypothetical protein TcasGA2_TC015986 [Tribolium castaneum]>gi|625293659|gb|AHY24027.1| lethal giant larvae [Tribolium castaneum] -- -- -- -- -- K06094 LLGL lethal(2) giant larvae protein http://www.genome.jp/dbget-bin/www_bget?ko:K06094 Q08470 1450 6.9e-159 Protein lethal(2) giant larvae OS=Drosophila pseudoobscura pseudoobscura GN=l(2)gl PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1983 Tomosyn and related SNARE-interacting proteins Cluster-8309.46002 BF_2 126.97 1.12 5013 91090308 XP_972041.1 1907 2.4e-210 PREDICTED: mitochondrial enolase superfamily member 1 [Tribolium castaneum]>gi|270013803|gb|EFA10251.1| hypothetical protein TcasGA2_TC012451 [Tribolium castaneum] 27633565 BX060284.1 95 3.53048e-39 Single read from an extremity of a full-length cDNA clone made from Anopheles gambiae total adult females. 3-PRIME end of clone FK0AAC40CD04 of strain 6-9 of Anopheles gambiae (African malaria mosquito) K18334 fucD L-fuconate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K18334 Q6INX4 1346 1.1e-146 Mitochondrial enolase superfamily member 1 OS=Xenopus laevis GN=enosf1 PE=2 SV=1 PF08116 PhTx neurotoxin family GO:0009405//GO:0009063 pathogenesis//cellular amino acid catabolic process GO:0003824 catalytic activity GO:0005576 extracellular region -- -- Cluster-8309.46003 BF_2 533.80 27.24 1107 91087837 XP_967757.1 1005 2.1e-106 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270012001|gb|EFA08449.1| hypothetical protein TcasGA2_TC006096 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 710 1.4e-73 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01370//PF01715 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//IPP transferase GO:0008207//GO:0008033//GO:0008209//GO:0006694//GO:0055114//GO:0008210 C21-steroid hormone metabolic process//tRNA processing//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//estrogen metabolic process GO:0050662//GO:0003824//GO:0003854//GO:0016616 coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1221 Acyl-CoA reductase Cluster-8309.46005 BF_2 146.00 1.50 4352 642930648 XP_008199209.1 3390 0.0e+00 PREDICTED: gamma-tubulin complex component 6 [Tribolium castaneum] -- -- -- -- -- K16573 TUBGCP6, GCP6 gamma-tubulin complex component 6 http://www.genome.jp/dbget-bin/www_bget?ko:K16573 Q96RT7 575 2.5e-57 Gamma-tubulin complex component 6 OS=Homo sapiens GN=TUBGCP6 PE=1 SV=3 PF04130 Spc97 / Spc98 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0000922//GO:0005815 spindle pole//microtubule organizing center KOG2001 Gamma-tubulin complex, DGRIP84/SPC97 component Cluster-8309.46006 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46007 BF_2 401.03 8.56 2246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46008 BF_2 234.49 1.60 6432 642921412 XP_008192854.1 1114 2.8e-118 PREDICTED: out at first protein [Tribolium castaneum] 195035062 XM_001988996.1 113 4.47121e-49 Drosophila grimshawi GH10264 (Dgri\GH10264), mRNA -- -- -- -- O18638 791 3.3e-82 Out at first protein OS=Drosophila virilis GN=oaf PE=3 SV=1 PF05648//PF00937 Peroxisomal biogenesis factor 11 (PEX11)//Coronavirus nucleocapsid protein GO:0016559 peroxisome fission -- -- GO:0019013//GO:0005779 viral nucleocapsid//integral component of peroxisomal membrane -- -- Cluster-8309.46009 BF_2 78.17 0.84 4191 642913916 XP_008201212.1 3081 0.0e+00 PREDICTED: ribosomal protein S6 kinase 2 beta isoform X1 [Tribolium castaneum] 755870656 XM_005181954.2 137 1.32363e-62 PREDICTED: Musca domestica ribosomal protein S6 kinase 2 beta (LOC101895137), mRNA K04373 RPS6KA, RSK2 p90 ribosomal S6 kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04373 P51812 2107 5.4e-235 Ribosomal protein S6 kinase alpha-3 OS=Homo sapiens GN=RPS6KA3 PE=1 SV=1 PF00433//PF07714//PF06293//PF00069 Protein kinase C terminal domain//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0016773//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0603 Ribosomal protein S6 kinase Cluster-8309.46011 BF_2 159.62 2.37 3099 642926040 XP_008194740.1 3084 0.0e+00 PREDICTED: acetyl-CoA carboxylase isoform X1 [Tribolium castaneum] 158292710 XM_314071.4 653 0 Anopheles gambiae str. PEST AGAP005175-PB (AgaP_AGAP005175) mRNA, complete cds K11262 ACACA acetyl-CoA carboxylase / biotin carboxylase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11262 O00763 2377 1.9e-266 Acetyl-CoA carboxylase 2 OS=Homo sapiens GN=ACACB PE=1 SV=3 PF02655//PF02786//PF07478 ATP-grasp domain//Carbamoyl-phosphate synthase L chain, ATP binding domain//D-ala D-ala ligase C-terminus GO:0009252//GO:0046436 peptidoglycan biosynthetic process//D-alanine metabolic process GO:0046872//GO:0008716//GO:0005524 metal ion binding//D-alanine-D-alanine ligase activity//ATP binding -- -- KOG0368 Acetyl-CoA carboxylase Cluster-8309.46014 BF_2 44.69 0.87 2448 21218350 AAM44045.1 2540 4.7e-284 arylphorin-like hexamerin [Apriona germari] 21218349 AF509880.1 489 0 Apriona germari arylphorin-like hexamerin mRNA, complete cds -- -- -- -- Q17127 1167 3.1e-126 Hexamerin OS=Blaberus discoidalis PE=2 SV=1 PF12464 Maltose acetyltransferase GO:0042967 acyl-carrier-protein biosynthetic process GO:0016407 acetyltransferase activity -- -- -- -- Cluster-8309.46018 BF_2 233.25 2.12 4881 189236382 XP_969620.2 2293 4.1e-255 PREDICTED: serine/threonine-protein kinase PAK mbt [Tribolium castaneum] 158287954 XM_309828.4 261 1.80829e-131 Anopheles gambiae str. PEST AGAP010874-PA (AgaP_AGAP010874) mRNA, complete cds K05736 PAK7 p21-activated kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05736 Q9VXE5 1526 1.5e-167 Serine/threonine-protein kinase PAK mbt OS=Drosophila melanogaster GN=mbt PE=1 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein kinase activity GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.46019 BF_2 131.75 1.27 4633 189236382 XP_969620.2 2293 3.9e-255 PREDICTED: serine/threonine-protein kinase PAK mbt [Tribolium castaneum] 158287954 XM_309828.4 261 1.71573e-131 Anopheles gambiae str. PEST AGAP010874-PA (AgaP_AGAP010874) mRNA, complete cds K05736 PAK7 p21-activated kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05736 Q9VXE5 1526 1.4e-167 Serine/threonine-protein kinase PAK mbt OS=Drosophila melanogaster GN=mbt PE=1 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.46020 BF_2 679.00 15.91 2073 270010572 EFA07020.1 714 2.2e-72 hypothetical protein TcasGA2_TC009991 [Tribolium castaneum] 642929657 XM_970383.2 189 8.05182e-92 PREDICTED: Tribolium castaneum AP-2 complex subunit sigma (LOC664376), mRNA K11827 AP2S1 AP-2 complex subunit sigma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K11827 P62744 692 3.2e-71 AP-2 complex subunit sigma OS=Rattus norvegicus GN=Ap2s1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0935 Clathrin adaptor complex, small subunit Cluster-8309.46021 BF_2 362.61 5.39 3100 91079410 XP_967066.1 1352 3.4e-146 PREDICTED: nudC domain-containing protein 1 [Tribolium castaneum]>gi|270003473|gb|EEZ99920.1| hypothetical protein TcasGA2_TC002712 [Tribolium castaneum] -- -- -- -- -- K07071 K07071 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K07071 Q6PIP5 687 1.8e-70 NudC domain-containing protein 1 OS=Mus musculus GN=Nudcd1 PE=2 SV=2 PF01370//PF02827//PF00070 NAD dependent epimerase/dehydratase family//cAMP-dependent protein kinase inhibitor//Pyridine nucleotide-disulphide oxidoreductase GO:0045859//GO:0006469//GO:0055114 regulation of protein kinase activity//negative regulation of protein kinase activity//oxidation-reduction process GO:0016491//GO:0050662//GO:0003824//GO:0004862 oxidoreductase activity//coenzyme binding//catalytic activity//cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex KOG4379 Uncharacterized conserved protein (tumor antigen CML66 in humans) Cluster-8309.46022 BF_2 11.00 0.85 830 3907620 AAC78681.1 346 4.1e-30 actin 1 [Penaeus monodon] 795401007 XM_012087502.1 131 5.49239e-60 PREDICTED: Cercocebus atys actin, beta (ACTB), mRNA K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 P90689 341 6.4e-31 Actin OS=Brugia malayi PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.46025 BF_2 783.11 15.74 2369 91093509 XP_969295.1 1113 1.3e-118 PREDICTED: ras-related protein Rab-39B [Tribolium castaneum]>gi|270002676|gb|EEZ99123.1| hypothetical protein TcasGA2_TC005229 [Tribolium castaneum] -- -- -- -- -- K07925 RAB39B Ras-related protein Rab-39B http://www.genome.jp/dbget-bin/www_bget?ko:K07925 Q8BHD0 613 5.2e-62 Ras-related protein Rab-39A OS=Mus musculus GN=Rab39a PE=1 SV=1 PF03193//PF08477//PF01926//PF00025//PF04670//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0098 GTPase Rab2, small G protein superfamily Cluster-8309.46029 BF_2 259.54 1.68 6735 270016510 EFA12956.1 3014 0.0e+00 pumilio [Tribolium castaneum] 642939433 XM_008202167.1 706 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X2, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.7e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806 CPL (NUC119) domain//Pumilio-family RNA binding repeat -- -- GO:0003723 RNA binding -- -- KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.46033 BF_2 39.00 3.77 720 795016637 XP_011858564.1 169 1.2e-09 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01429 Methyl-CpG binding domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.46035 BF_2 57.26 4.49 821 642937344 XP_008198797.1 914 5.5e-96 PREDICTED: centaurin-gamma-1A [Tribolium castaneum] 701339117 XM_009982980.1 84 7.27745e-34 PREDICTED: Tauraco erythrolophus arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3-like (LOC104376406), partial mRNA K12491 AGAP1_3 Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12491 Q9NGC3 790 5.4e-83 Centaurin-gamma-1A OS=Drosophila melanogaster GN=CenG1A PE=2 SV=2 PF00071//PF08477 Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0705 GTPase-activating protein Centaurin gamma (contains Ras-like GTPase, PH and ankyrin repeat domains) Cluster-8309.46037 BF_2 14.09 0.47 1551 642919164 XP_008191764.1 1201 5.5e-129 PREDICTED: forkhead box protein N3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09407 FOXN forkhead box protein N http://www.genome.jp/dbget-bin/www_bget?ko:K09407 Q499D0 446 7.9e-43 Forkhead box protein N3 OS=Mus musculus GN=Foxn3 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.46038 BF_2 523.82 4.39 5274 642919164 XP_008191764.1 1586 4.2e-173 PREDICTED: forkhead box protein N3-like isoform X2 [Tribolium castaneum] 642919163 XM_008193542.1 45 2.31674e-11 PREDICTED: Tribolium castaneum forkhead box protein N3-like (LOC100141565), transcript variant X5, mRNA K09407 FOXN forkhead box protein N http://www.genome.jp/dbget-bin/www_bget?ko:K09407 Q499D0 451 7.1e-43 Forkhead box protein N3 OS=Mus musculus GN=Foxn3 PE=1 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.46039 BF_2 9.98 0.42 1274 189240236 XP_001811057.1 1228 3.3e-132 PREDICTED: calcium-binding mitochondrial carrier protein SCaMC-2 [Tribolium castaneum] 662186350 XM_008483497.1 54 5.44312e-17 PREDICTED: Diaphorina citri calcium-binding mitochondrial carrier protein SCaMC-2-B-like (LOC103518432), mRNA K14684 SLC25A23S solute carrier family 25 (mitochondrial phosphate transporter), member 23/24/25/41 http://www.genome.jp/dbget-bin/www_bget?ko:K14684 Q0V7M4 858 1.1e-90 Calcium-binding mitochondrial carrier protein SCaMC-2 OS=Bos taurus GN=SLC25A25 PE=2 SV=1 PF13499//PF10591//PF13833//PF00036//PF13405//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//EF hand GO:0007165 signal transduction GO:0005509 calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0036 Predicted mitochondrial carrier protein Cluster-8309.46040 BF_2 295.86 1.91 6780 649572237 NP_001280538.1 2012 2.2e-222 5-hydroxytryptamine receptor [Tribolium castaneum]>gi|510960964|gb|AGN56420.1| serotonin receptor type 1 [Tribolium castaneum] 195584787 XM_002082150.1 80 1.0424e-30 Drosophila simulans GD11428 (Dsim\GD11428), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25190 1208 1.5e-130 5-hydroxytryptamine receptor OS=Heliothis virescens PE=2 SV=1 PF00974//PF00001 Rhabdovirus spike glycoprotein//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.46041 BF_2 128.08 1.05 5386 642927663 XP_008195354.1 1331 1.6e-143 PREDICTED: cAMP-regulated phosphoprotein 21 isoform X3 [Tribolium castaneum] -- -- -- -- -- K02360 ENC a component of the cytoplasm (encore) http://www.genome.jp/dbget-bin/www_bget?ko:K02360 A0JNC2 395 2.3e-36 R3H domain-containing protein 2 OS=Bos taurus GN=R3HDM2 PE=2 SV=1 PF01424 R3H domain -- -- GO:0003676 nucleic acid binding -- -- KOG2953 mRNA-binding protein Encore Cluster-8309.46042 BF_2 84.37 2.25 1858 546684200 ERL93905.1 259 1.1e-19 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46043 BF_2 221.92 4.03 2591 91094007 XP_971310.1 1623 1.1e-177 PREDICTED: DENN domain-containing protein 1A isoform X1 [Tribolium castaneum]>gi|270016162|gb|EFA12610.1| hypothetical protein TcasGA2_TC006851 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F67 410 2.0e-38 DENN domain-containing protein 1A OS=Xenopus laevis GN=dennd1a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3569 RAS signaling inhibitor ST5 Cluster-8309.46044 BF_2 8.18 0.68 789 546681137 ERL91287.1 231 8.4e-17 hypothetical protein D910_08620 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q61704 147 1.9e-08 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Mus musculus GN=Itih3 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46045 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46049 BF_2 77.40 2.88 1412 154416570 XP_001581307.1 396 1.1e-35 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121915533|gb|EAY20321.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 360 6.8e-33 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023//PF02263//PF05396 Ankyrin repeat//Ankyrin repeat//Guanylate-binding protein, N-terminal domain//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0003924//GO:0005515//GO:0005525 GTPase activity//protein binding//GTP binding -- -- KOG4177 Ankyrin Cluster-8309.4605 BF_2 2.00 0.45 474 478251927 ENN72365.1 308 5.9e-26 hypothetical protein YQE_11000, partial [Dendroctonus ponderosae]>gi|546671230|gb|ERL83629.1| hypothetical protein D910_00764 [Dendroctonus ponderosae]>gi|546671841|gb|ERL83978.1| hypothetical protein D910_01294 [Dendroctonus ponderosae] -- -- -- -- -- K12620 LSM1 U6 snRNA-associated Sm-like protein LSm1 http://www.genome.jp/dbget-bin/www_bget?ko:K12620 Q5E9Z8 285 1.1e-24 U6 snRNA-associated Sm-like protein LSm1 OS=Bos taurus GN=LSM1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1782 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.46050 BF_2 42.00 1.30 1638 780132859 XP_011679540.1 377 2.0e-33 PREDICTED: uncharacterized protein LOC105445556 [Strongylocentrotus purpuratus] -- -- -- -- -- K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q4UMH6 312 2.9e-27 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46051 BF_2 99.60 4.42 1230 642934260 XP_008200857.1 605 5.6e-60 PREDICTED: uncharacterized protein LOC103314998 isoform X23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4UMH6 529 1.5e-52 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.46055 BF_2 43.69 1.03 2064 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01132 Elongation factor P (EF-P) OB domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005840 ribosome -- -- Cluster-8309.46056 BF_2 228.72 2.64 3916 642938306 XP_008192805.1 639 2.0e-63 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X3 [Tribolium castaneum] 642938305 XM_008194583.1 200 1.1763e-97 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X4, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 Q9VWW0 222 1.9e-16 Cyclic AMP response element-binding protein B OS=Drosophila melanogaster GN=CrebB PE=1 SV=1 PF07716//PF00170//PF02173//PF03131 Basic region leucine zipper//bZIP transcription factor//pKID domain//bZIP Maf transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.46057 BF_2 12.92 0.33 1933 642910932 XP_008193471.1 964 2.1e-101 PREDICTED: kinesin-like protein KIF13A isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46060 BF_2 66.35 2.07 1631 478258496 ENN78571.1 1843 2.1e-203 hypothetical protein YQE_04939, partial [Dendroctonus ponderosae]>gi|546677392|gb|ERL88238.1| hypothetical protein D910_05626 [Dendroctonus ponderosae] 768436038 XM_011561181.1 53 2.52177e-16 PREDICTED: Plutella xylostella PRKCA-binding protein-like (LOC105389970), mRNA -- -- -- -- Q5REH1 1208 3.7e-131 PRKCA-binding protein OS=Pongo abelii GN=PICK1 PE=2 SV=1 PF13180//PF06456//PF00595 PDZ domain//Arfaptin-like domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0019904//GO:0005515 protein domain specific binding//protein binding -- -- KOG3651 Protein kinase C, alpha binding protein Cluster-8309.46061 BF_2 36.74 1.20 1570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46062 BF_2 252.70 2.20 5085 642918584 XP_966986.2 1643 1.0e-179 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0NGI1 259 1.3e-20 Transmembrane protein 234 homolog OS=Anopheles gambiae GN=AGAP012180 PE=3 SV=1 PF16331//PF04977//PF13855//PF06005//PF00892//PF10392//PF07926//PF00560 TolA binding protein trimerisation//Septum formation initiator//Leucine rich repeat//Protein of unknown function (DUF904)//EamA-like transporter family//Golgi transport complex subunit 5//TPR/MLP1/MLP2-like protein//Leucine Rich Repeat GO:0006606//GO:0043093//GO:0000917//GO:0007049//GO:0006891//GO:0070206 protein import into nucleus//FtsZ-dependent cytokinesis//barrier septum assembly//cell cycle//intra-Golgi vesicle-mediated transport//protein trimerization GO:0005515 protein binding GO:0016020//GO:0017119//GO:0005737//GO:0016021 membrane//Golgi transport complex//cytoplasm//integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.46063 BF_2 21.89 0.34 2985 91087321 XP_975587.1 665 1.5e-66 PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|642929809|ref|XP_008195985.1| PREDICTED: ras-like protein 2 [Tribolium castaneum]>gi|270009526|gb|EFA05974.1| hypothetical protein TcasGA2_TC008799 [Tribolium castaneum] 186969251 EU616728.1 55 3.60096e-17 Kryptolebias marmoratus R-ras3 mRNA, complete cds K07830 RRAS2, TC21 Ras-related protein R-Ras2 http://www.genome.jp/dbget-bin/www_bget?ko:K07830 P04388 507 1.3e-49 Ras-like protein 2 OS=Drosophila melanogaster GN=Ras64B PE=1 SV=2 PF00071//PF00025//PF08469//PF08477 Ras family//ADP-ribosylation factor family//Nucleoside triphosphatase I C-terminal//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0006184//GO:0006351 small GTPase mediated signal transduction//obsolete GTP catabolic process//transcription, DNA-templated GO:0017111//GO:0005525//GO:0003924//GO:0005524 nucleoside-triphosphatase activity//GTP binding//GTPase activity//ATP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.46065 BF_2 316.51 0.81 16732 765150019 XP_011485511.1 427 3.3e-38 PREDICTED: ring-infected erythrocyte surface antigen-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- P25386 202 1.7e-13 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46067 BF_2 652.22 5.92 4893 642930421 XP_008196394.1 3685 0.0e+00 PREDICTED: tyrosine-protein kinase hopscotch [Tribolium castaneum] 755985098 XM_011312437.1 47 1.66068e-12 PREDICTED: Fopius arisanus tyrosine-protein kinase hopscotch (LOC105271102), mRNA K04447 JAK2 Janus kinase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04447 Q24592 570 1.1e-56 Tyrosine-protein kinase hopscotch OS=Drosophila melanogaster GN=hop PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.46070 BF_2 12.87 4.72 400 270006872 EFA03320.1 172 2.9e-10 hypothetical protein TcasGA2_TC013263 [Tribolium castaneum] 642924012 XM_970745.2 112 9.24044e-50 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X2, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 155 1.1e-09 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00503 G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0019001//GO:0004871//GO:0031683 GTPase activity//guanyl nucleotide binding//signal transducer activity//G-protein beta/gamma-subunit complex binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46071 BF_2 141.00 6.02 1267 91083543 XP_975838.1 738 2.2e-75 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha isoform X2 [Tribolium castaneum] 805773141 XM_012281746.1 191 3.76276e-93 PREDICTED: Megachile rotundata guanine nucleotide-binding protein G(o) subunit alpha (LOC100880970), transcript variant X3, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 722 6.4e-75 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00025//PF00503 ADP-ribosylation factor family//G-protein alpha subunit GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005525//GO:0031683//GO:0019001//GO:0004871 GTPase activity//GTP binding//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46073 BF_2 33.69 0.99 1712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46074 BF_2 372.00 35.14 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46078 BF_2 76.42 2.30 1678 826420612 XP_012525240.1 917 5.1e-96 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 321 2.71601e-165 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 915 3.6e-97 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00503//PF00025//PF01580 G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0003677//GO:0031683//GO:0005524//GO:0004871//GO:0019001//GO:0005525//GO:0000166 GTPase activity//DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//signal transducer activity//guanyl nucleotide binding//GTP binding//nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46081 BF_2 6.67 0.57 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46084 BF_2 9.97 0.74 847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46085 BF_2 23.87 1.05 1241 531445092 AGT57838.1 365 3.8e-32 cytochrome P450 413a1 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27902 212 8.7e-16 Cytochrome P450 6B4 OS=Papilio glaucus GN=CYP6B4 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.46090 BF_2 174.00 7.41 1270 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46091 BF_2 15.06 0.49 1581 826420612 XP_012525240.1 917 4.8e-96 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 321 2.55566e-165 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 915 3.3e-97 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00503//PF00025//PF01580 G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0003924//GO:0005524//GO:0003677//GO:0031683//GO:0000166//GO:0005525//GO:0004871//GO:0019001 GTPase activity//ATP binding//DNA binding//G-protein beta/gamma-subunit complex binding//nucleotide binding//GTP binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46095 BF_2 12.80 2.14 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00974 Rhabdovirus spike glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.46096 BF_2 155.30 7.16 1194 826420612 XP_012525240.1 954 1.8e-100 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 327 8.85108e-169 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 952 1.3e-101 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF08477//PF00503//PF00025//PF01580//PF04670 Ras of Complex, Roc, domain of DAPkinase//G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family//Gtr1/RagA G protein conserved region GO:0007264//GO:0007186//GO:0007165 small GTPase mediated signal transduction//G-protein coupled receptor signaling pathway//signal transduction GO:0000166//GO:0005525//GO:0019001//GO:0004871//GO:0003924//GO:0005524//GO:0031683//GO:0003677 nucleotide binding//GTP binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//DNA binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46098 BF_2 11.97 0.38 1590 826420612 XP_012525240.1 917 4.8e-96 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Monomorium pharaonis] 642924011 XM_961328.2 321 2.57054e-165 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC655023), transcript variant X1, mRNA K04534 GNAO, G-ALPHA-O guanine nucleotide-binding protein G(o) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04534 P38404 915 3.4e-97 Guanine nucleotide-binding protein G(o) subunit alpha OS=Locusta migratoria PE=3 SV=1 PF00503//PF00025//PF01580 G-protein alpha subunit//ADP-ribosylation factor family//FtsK/SpoIIIE family GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0031683//GO:0003677//GO:0005524//GO:0003924//GO:0019001//GO:0004871//GO:0000166//GO:0005525 G-protein beta/gamma-subunit complex binding//DNA binding//ATP binding//GTPase activity//guanyl nucleotide binding//signal transducer activity//nucleotide binding//GTP binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.46099 BF_2 1268.90 9.11 6117 478256710 ENN76892.1 1622 3.3e-177 hypothetical protein YQE_06733, partial [Dendroctonus ponderosae]>gi|546685091|gb|ERL94618.1| hypothetical protein D910_11895 [Dendroctonus ponderosae] 749732005 XM_011139608.1 230 3.87931e-114 PREDICTED: Harpegnathos saltator mitogen-activated protein kinase 14B-like (LOC105182275), transcript variant X1, mRNA K04441 P38 p38 MAP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04441 O61443 1360 3.3e-148 Mitogen-activated protein kinase 14B OS=Drosophila melanogaster GN=p38b PE=1 SV=1 PF07714//PF01762//PF02434//PF06293//PF00069//PF13414 Protein tyrosine kinase//Galactosyltransferase//Fringe-like//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//TPR repeat GO:0006486//GO:0006468 protein glycosylation//protein phosphorylation GO:0008378//GO:0004672//GO:0016773//GO:0005515//GO:0005524//GO:0016757 galactosyltransferase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//protein binding//ATP binding//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG0660 Mitogen-activated protein kinase Cluster-8309.46100 BF_2 214.00 4.77 2162 642923314 XP_972670.2 1929 2.9e-213 PREDICTED: T-box transcription factor TBX20 [Tribolium castaneum] 642923313 XM_967577.2 521 0 PREDICTED: Tribolium castaneum H15 protein (LOC661420), mRNA K10185 TBX20 T-box protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10185 Q94890 986 2.7e-105 T-box protein H15 OS=Drosophila melanogaster GN=H15 PE=2 SV=2 PF00907 T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3586 TBX1 and related T-box transcription factors Cluster-8309.46102 BF_2 122.74 1.13 4828 478251982 ENN72418.1 2639 3.1e-295 hypothetical protein YQE_10936, partial [Dendroctonus ponderosae] 562831337 XM_006145090.1 42 9.86098e-10 PREDICTED: Tupaia chinensis tripartite motif containing 24 (TRIM24), mRNA K08883 TRIM33, TIF1G tripartite motif-containing protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K08883 Q56R14 487 4.4e-47 E3 ubiquitin-protein ligase TRIM33 OS=Xenopus laevis GN=trim33 PE=1 SV=1 PF13639//PF00439//PF01361//PF00097//PF00643//PF14634//PF00628 Ring finger domain//Bromodomain//Tautomerase enzyme//Zinc finger, C3HC4 type (RING finger)//B-box zinc finger//zinc-RING finger domain//PHD-finger GO:0006725 cellular aromatic compound metabolic process GO:0008270//GO:0005515//GO:0046872//GO:0016853 zinc ion binding//protein binding//metal ion binding//isomerase activity GO:0005622 intracellular -- -- Cluster-8309.46106 BF_2 61.09 3.11 1110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46108 BF_2 88.15 0.37 10294 478255274 ENN75503.1 1875 2.6e-206 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] 815822303 XM_012377001.1 72 4.43996e-26 PREDICTED: Linepithema humile DNA primase small subunit (LOC105678028), mRNA K02684 PRI1 DNA primase small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K02684 Q24317 1060 3.4e-113 DNA primase small subunit OS=Drosophila melanogaster GN=DNApol-alpha50 PE=2 SV=2 PF01896//PF00057//PF13180//PF00884//PF00595 Eukaryotic and archaeal DNA primase small subunit//Low-density lipoprotein receptor domain class A//PDZ domain//Sulfatase//PDZ domain (Also known as DHR or GLGF) GO:0006269//GO:0006351//GO:0008152 DNA replication, synthesis of RNA primer//transcription, DNA-templated//metabolic process GO:0008484//GO:0005515//GO:0003896 sulfuric ester hydrolase activity//protein binding//DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork -- -- Cluster-8309.46109 BF_2 2.00 0.72 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46110 BF_2 433.00 108.34 454 817056880 XP_012269325.1 158 1.4e-08 PREDICTED: uncharacterized protein LOC105693774 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46111 BF_2 775.00 71.12 743 91094513 XP_971885.1 559 7.3e-55 PREDICTED: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial [Tribolium castaneum]>gi|270001243|gb|EEZ97690.1| lethal neo18 [Tribolium castaneum] -- -- -- -- -- K03961 NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03961 Q02380 236 8.5e-19 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial OS=Bos taurus GN=NDUFB5 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46112 BF_2 19.29 1.18 973 641681966 XP_008189661.1 241 7.2e-18 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like, partial [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- A4IFA3 190 2.4e-13 General transcription factor II-I repeat domain-containing protein 2 OS=Bos taurus GN=GTF2IRD2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46113 BF_2 1.00 0.87 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46114 BF_2 5.56 0.35 948 478260882 ENN80519.1 270 3.0e-21 hypothetical protein YQE_03058, partial [Dendroctonus ponderosae]>gi|546671739|gb|ERL83923.1| hypothetical protein D910_01216 [Dendroctonus ponderosae]>gi|546675041|gb|ERL86299.1| hypothetical protein D910_03707 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04814 Hepatocyte nuclear factor 1 (HNF-1), N terminus GO:0045893 positive regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.46117 BF_2 270.11 3.64 3390 91093659 XP_966349.1 2937 0.0e+00 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] 686775201 LM127048.1 46 4.12457e-12 Taenia asiatica genome assembly T_asiatica_South_Korea ,scaffold TASK_contig0000687 K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 Q9W3K5 2018 9.0e-225 Glutamate--cysteine ligase OS=Drosophila melanogaster GN=Gclc PE=2 SV=1 PF03074//PF00355 Glutamate-cysteine ligase//Rieske [2Fe-2S] domain GO:0006749//GO:0055114//GO:0006750 glutathione metabolic process//oxidation-reduction process//glutathione biosynthetic process GO:0051537//GO:0016491//GO:0004357 2 iron, 2 sulfur cluster binding//oxidoreductase activity//glutamate-cysteine ligase activity GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.46118 BF_2 162.17 1.65 4394 91093659 XP_966349.1 2003 1.6e-221 PREDICTED: glutamate--cysteine ligase catalytic subunit [Tribolium castaneum]>gi|270008080|gb|EFA04528.1| hypothetical protein TcasGA2_TC016323 [Tribolium castaneum] 686775201 LM127048.1 46 5.35923e-12 Taenia asiatica genome assembly T_asiatica_South_Korea ,scaffold TASK_contig0000687 K11204 GCLC glutamate--cysteine ligase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K11204 P19468 1367 3.6e-149 Glutamate--cysteine ligase catalytic subunit OS=Rattus norvegicus GN=Gclc PE=1 SV=2 PF03074//PF00355 Glutamate-cysteine ligase//Rieske [2Fe-2S] domain GO:0006749//GO:0006750//GO:0055114 glutathione metabolic process//glutathione biosynthetic process//oxidation-reduction process GO:0051537//GO:0004357//GO:0016491 2 iron, 2 sulfur cluster binding//glutamate-cysteine ligase activity//oxidoreductase activity GO:0017109 glutamate-cysteine ligase complex KOG3754 Gamma-glutamylcysteine synthetase Cluster-8309.46119 BF_2 3.00 3.08 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46121 BF_2 71.09 0.59 5300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46126 BF_2 20.00 3.37 535 123507472 XP_001329422.1 295 2.2e-24 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121912377|gb|EAY17199.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K10324 ASB2 ankyrin repeat and SOCS box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10324 Q9J569 240 2.1e-19 Putative ankyrin repeat protein FPV162 OS=Fowlpox virus (strain NVSL) GN=FPV162 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46128 BF_2 248.77 3.32 3422 642936562 XP_008198486.1 1449 2.1e-157 PREDICTED: somatostatin receptor type 2 isoform X1 [Tribolium castaneum] 462360042 APGK01029530.1 119 1.09402e-52 Dendroctonus ponderosae Seq01029540, whole genome shotgun sequence K04218 SSTR2 somatostatin receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04218 P30874 580 5.1e-58 Somatostatin receptor type 2 OS=Homo sapiens GN=SSTR2 PE=1 SV=1 PF13994//PF00001 PgaD-like protein//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0042710 G-protein coupled receptor signaling pathway//biofilm formation GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.46129 BF_2 278.25 5.84 2282 642926882 XP_008195051.1 1690 1.6e-185 PREDICTED: probable cation-transporting ATPase 13A3 isoform X3 [Tribolium castaneum] 759064686 XM_011343453.1 68 1.62863e-24 PREDICTED: Cerapachys biroi probable cation-transporting ATPase 13A3 (LOC105281898), transcript variant X2, mRNA K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 985 3.7e-105 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF06399//PF00122 P5-type ATPase cation transporter//GTP cyclohydrolase I feedback regulatory protein (GFRP)//E1-E2 ATPase GO:0009890//GO:0006812 negative regulation of biosynthetic process//cation transport GO:0046872//GO:0016887//GO:0000166 metal ion binding//ATPase activity//nucleotide binding GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.46130 BF_2 180.18 4.62 1918 91076534 XP_973776.1 777 9.9e-80 PREDICTED: snRNA-activating protein complex subunit 3 [Tribolium castaneum]>gi|270002398|gb|EEZ98845.1| hypothetical protein TcasGA2_TC004455 [Tribolium castaneum] -- -- -- -- -- K15210 SNAPC3 snRNA-activating protein complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15210 Q5E9M5 334 9.6e-30 snRNA-activating protein complex subunit 3 OS=Bos taurus GN=SNAPC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2664 Small nuclear RNA activating protein complex - 50kD subunit (SNAP50) Cluster-8309.46131 BF_2 205.51 0.58 15155 546683698 ERL93476.1 2777 1.2e-310 hypothetical protein D910_10767, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07535 Zinc finger, C2H2 type//DBF zinc finger -- -- GO:0046872//GO:0008270//GO:0003676 metal ion binding//zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.46132 BF_2 166.23 1.74 4273 642927998 XP_008195478.1 2546 1.7e-284 PREDICTED: LOW QUALITY PROTEIN: DNA replication licensing factor Mcm5 [Tribolium castaneum] 686484113 KM036513.1 190 4.65281e-92 Locusta migratoria Mcm5 mRNA, complete cds K02209 MCM5, CDC46 DNA replication licensing factor MCM5 http://www.genome.jp/dbget-bin/www_bget?ko:K02209 Q9VGW6 2277 1.1e-254 DNA replication licensing factor Mcm5 OS=Drosophila melanogaster GN=Mcm5 PE=1 SV=1 PF00493//PF00004//PF07728//PF07726//PF00158 MCM2/3/5 family//ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Sigma-54 interaction domain GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008134//GO:0016887//GO:0003677//GO:0005524 transcription factor binding//ATPase activity//DNA binding//ATP binding GO:0005667 transcription factor complex KOG0481 DNA replication licensing factor, MCM5 component Cluster-8309.46135 BF_2 349.00 6.62 2492 546684523 ERL94154.1 2540 4.8e-284 hypothetical protein D910_11436 [Dendroctonus ponderosae] -- -- -- -- -- K13142 INTS5 integrator complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13142 Q8CHT3 675 3.6e-69 Integrator complex subunit 5 OS=Mus musculus GN=Ints5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46136 BF_2 14.00 1.02 864 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06858//PF02259 Nucleolar GTP-binding protein 1 (NOG1)//FAT domain -- -- GO:0005515//GO:0005525 protein binding//GTP binding -- -- -- -- Cluster-8309.46137 BF_2 23.00 1.92 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46139 BF_2 18.35 0.33 2634 642926809 XP_008195022.1 416 9.9e-38 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9PVG3 262 2.9e-21 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF04120//PF01309//PF00096//PF13465//PF07776 Low affinity iron permease//Equine arteritis virus small envelope glycoprotein//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD) GO:0055085 transmembrane transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0019031//GO:0005634 viral envelope//nucleus -- -- Cluster-8309.46141 BF_2 33.34 0.47 3233 642914563 XP_008201731.1 497 4.9e-47 PREDICTED: histone-lysine N-methyltransferase ash1 isoform X2 [Tribolium castaneum]>gi|270001477|gb|EEZ97924.1| hypothetical protein TcasGA2_TC000311 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0032259 methylation GO:0008168//GO:0043169 methyltransferase activity//cation binding -- -- -- -- Cluster-8309.46142 BF_2 92.22 1.32 3217 91083297 XP_974591.1 1894 5.0e-209 PREDICTED: probable cysteine desulfurase, mitochondrial [Tribolium castaneum]>gi|270007737|gb|EFA04185.1| hypothetical protein TcasGA2_TC014434 [Tribolium castaneum] -- -- -- -- -- K04487 iscS, NFS1 cysteine desulfurase http://www.genome.jp/dbget-bin/www_bget?ko:K04487 Q9VKD3 1773 2.2e-196 Probable cysteine desulfurase, mitochondrial OS=Drosophila melanogaster GN=CG12264 PE=2 SV=1 PF08477//PF01926//PF00025//PF03193//PF00282//PF01212//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Protein of unknown function, DUF258//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//Gtr1/RagA G protein conserved region//Ras family GO:0006520//GO:0007264//GO:0019752//GO:0008152 cellular amino acid metabolic process//small GTPase mediated signal transduction//carboxylic acid metabolic process//metabolic process GO:0016829//GO:0005525//GO:0003924//GO:0030170//GO:0016831//GO:0003824 lyase activity//GTP binding//GTPase activity//pyridoxal phosphate binding//carboxy-lyase activity//catalytic activity -- -- KOG1549 Cysteine desulfurase NFS1 Cluster-8309.46143 BF_2 188.12 1.37 6031 642923145 XP_008193629.1 2730 1.1e-305 PREDICTED: nuclear receptor coactivator 1 isoform X8 [Tribolium castaneum] 642923146 XM_008195408.1 411 0 PREDICTED: Tribolium castaneum nuclear receptor coactivator 1 (LOC656017), transcript variant X9, mRNA K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 Q9WUI9 536 1.1e-52 Nuclear receptor coactivator 2 OS=Rattus norvegicus GN=Ncoa2 PE=1 SV=1 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.46144 BF_2 301.33 5.62 2529 270013857 EFA10305.1 160 4.6e-08 hypothetical protein TcasGA2_TC012520 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46145 BF_2 304.61 2.68 5034 642932649 XP_969929.2 1247 8.3e-134 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 886 2.5e-93 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.46147 BF_2 33.93 0.57 2777 91084661 XP_967669.1 1706 2.7e-187 PREDICTED: protein phosphatase 1D [Tribolium castaneum]>gi|270008629|gb|EFA05077.1| hypothetical protein TcasGA2_TC015174 [Tribolium castaneum] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 728 2.8e-75 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481 Protein phosphatase 2C GO:0006470 protein dephosphorylation GO:0004722//GO:0046872//GO:0003824 protein serine/threonine phosphatase activity//metal ion binding//catalytic activity GO:0008287 protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.46150 BF_2 277.35 4.26 3008 478253953 ENN74245.1 1772 6.5e-195 hypothetical protein YQE_09217, partial [Dendroctonus ponderosae]>gi|546674841|gb|ERL86127.1| hypothetical protein D910_03541 [Dendroctonus ponderosae] 150013142 CP000743.1 37 3.68075e-07 Methanococcus aeolicus Nankai-3, complete genome K07767 KATNA1 katanin p60 ATPase-containing subunit A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07767 B4USW8 1439 1.1e-157 Katanin p60 ATPase-containing subunit A-like 1 OS=Otolemur garnettii GN=KATNAL1 PE=3 SV=1 PF05496//PF01080//PF06068//PF01695//PF07728//PF03286//PF07724//PF00004//PF02562//PF02367//PF00910 Holliday junction DNA helicase ruvB N-terminus//Presenilin//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Pox virus Ag35 surface protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0006281//GO:0006310//GO:0002949 DNA repair//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0004190//GO:0003723//GO:0003678//GO:0005524//GO:0016887//GO:0003724//GO:0009378 aspartic-type endopeptidase activity//RNA binding//DNA helicase activity//ATP binding//ATPase activity//RNA helicase activity//four-way junction helicase activity GO:0009379//GO:0005657//GO:0016021//GO:0019031 Holliday junction helicase complex//replication fork//integral component of membrane//viral envelope KOG0738 AAA+-type ATPase Cluster-8309.46151 BF_2 91.46 1.06 3898 642918805 XP_008191593.1 3364 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 2055 5.3e-229 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF12409//PF00122 P5-type ATPase cation transporter//E1-E2 ATPase GO:0006812 cation transport GO:0046872//GO:0016887//GO:0000166 metal ion binding//ATPase activity//nucleotide binding GO:0016021 integral component of membrane KOG0208 Cation transport ATPase Cluster-8309.46152 BF_2 51.89 0.51 4551 546683303 ERL93135.1 344 3.8e-29 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 190 1.1e-12 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF06305 Trypsin//Protein of unknown function (DUF1049) GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.46160 BF_2 693.89 4.62 6570 642928935 XP_008195623.1 2125 1.7e-235 PREDICTED: regulator of G-protein signaling loco [Tribolium castaneum]>gi|270010425|gb|EFA06873.1| hypothetical protein TcasGA2_TC009818 [Tribolium castaneum] -- -- -- -- -- K17426 MRPL45 large subunit ribosomal protein L45 http://www.genome.jp/dbget-bin/www_bget?ko:K17426 Q9VCX1 1021 7.1e-109 Regulator of G-protein signaling loco OS=Drosophila melanogaster GN=loco PE=1 SV=2 PF00788//PF02188//PF00595//PF02196//PF07961//PF13180 Ras association (RalGDS/AF-6) domain//GoLoco motif//PDZ domain (Also known as DHR or GLGF)//Raf-like Ras-binding domain//MBA1-like protein//PDZ domain GO:0032979//GO:0007165 protein insertion into mitochondrial membrane from inner side//signal transduction GO:0005515//GO:0030695//GO:0005057 protein binding//GTPase regulator activity//receptor signaling protein activity GO:0005743 mitochondrial inner membrane KOG4599 Putative mitochondrial/chloroplast ribosomal protein L45 Cluster-8309.46163 BF_2 162.35 2.34 3194 478257607 ENN77759.1 781 5.7e-80 hypothetical protein YQE_05731, partial [Dendroctonus ponderosae]>gi|546677511|gb|ERL88337.1| hypothetical protein D910_05724, partial [Dendroctonus ponderosae] -- -- -- -- -- K09880 mtnC, ENOPH1 enolase-phosphatase E1 http://www.genome.jp/dbget-bin/www_bget?ko:K09880 Q17Q32 461 3.0e-44 Enolase-phosphatase E1 OS=Aedes aegypti GN=AAEL000109 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2630 Enolase-phosphatase E-1 Cluster-8309.46164 BF_2 624.49 23.52 1398 478250783 ENN71275.1 862 1.0e-89 hypothetical protein YQE_12200, partial [Dendroctonus ponderosae]>gi|546673018|gb|ERL84704.1| hypothetical protein D910_02129 [Dendroctonus ponderosae] -- -- -- -- -- K06999 K06999 phospholipase/carboxylesterase http://www.genome.jp/dbget-bin/www_bget?ko:K06999 Q3UFF7 515 7.1e-51 Lysophospholipase-like protein 1 OS=Mus musculus GN=Lyplal1 PE=1 SV=3 PF01764//PF07859//PF02230//PF00326//PF03583//PF00975//PF01738 Lipase (class 3)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Secretory lipase//Thioesterase domain//Dienelactone hydrolase family GO:0006508//GO:0016042//GO:0009058//GO:0046486//GO:0008152//GO:0006629 proteolysis//lipid catabolic process//biosynthetic process//glycerolipid metabolic process//metabolic process//lipid metabolic process GO:0008236//GO:0016788//GO:0016787//GO:0004806 serine-type peptidase activity//hydrolase activity, acting on ester bonds//hydrolase activity//triglyceride lipase activity -- -- KOG2112 Lysophospholipase Cluster-8309.46165 BF_2 77.63 0.38 8879 642938747 XP_008199872.1 1850 1.7e-203 PREDICTED: cytosolic purine 5'-nucleotidase isoform X2 [Tribolium castaneum] 41393060 NM_201427.1 39 8.46269e-08 Danio rerio 5'-nucleotidase, cytosolic IIa (nt5c2a), mRNA >gnl|BL_ORD_ID|2615369 Danio rerio 5'-nucleotidase, cytosolic II, mRNA (cDNA clone MGC:56594 IMAGE:5915251), complete cds K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 Q3V1L4 1401 8.3e-153 Cytosolic purine 5'-nucleotidase OS=Mus musculus GN=Nt5c2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.46167 BF_2 128.79 0.93 6074 642933274 XP_008197353.1 2089 2.3e-231 PREDICTED: PAB-dependent poly(A)-specific ribonuclease subunit PAN2 [Tribolium castaneum] 850480667 CP011888.1 37 7.47792e-07 Ovis canadensis canadensis isolate 43U chromosome 3 sequence K12571 PAN2 PAB-dependent poly(A)-specific ribonuclease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12571 Q5F450 822 7.8e-86 PAB-dependent poly(A)-specific ribonuclease subunit PAN2 OS=Gallus gallus GN=PAN2 PE=2 SV=1 PF01612//PF03798//PF09061//PF00443 3'-5' exonuclease//TLC domain//Stirrup//Ubiquitin carboxyl-terminal hydrolase GO:0006139//GO:0016579 nucleobase-containing compound metabolic process//protein deubiquitination GO:0016788//GO:0036459//GO:0003676//GO:0008408 hydrolase activity, acting on ester bonds//ubiquitinyl hydrolase activity//nucleic acid binding//3'-5' exonuclease activity GO:0016021 integral component of membrane KOG1275 PAB-dependent poly(A) ribonuclease, subunit PAN2 Cluster-8309.46168 BF_2 2724.47 122.44 1218 642934605 XP_971300.2 782 1.7e-80 PREDICTED: CD63 antigen [Tribolium castaneum] -- -- -- -- -- K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q9XSK2 375 1.1e-34 CD63 antigen OS=Bos taurus GN=CD63 PE=2 SV=4 PF13520//PF00115//PF09004//PF00335//PF05149 Amino acid permease//Cytochrome C and Quinol oxidase polypeptide I//Domain of unknown function (DUF1891)//Tetraspanin family//Paraflagellar rod protein GO:0003333//GO:0006865//GO:0015992//GO:0055114//GO:0006118//GO:0006123//GO:0009060 amino acid transmembrane transport//amino acid transport//proton transport//oxidation-reduction process//obsolete electron transport//mitochondrial electron transport, cytochrome c to oxygen//aerobic respiration GO:0004129//GO:0020037//GO:0016706//GO:0009055//GO:0005506//GO:0008168//GO:0005516//GO:0015171 cytochrome-c oxidase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//electron carrier activity//iron ion binding//methyltransferase activity//calmodulin binding//amino acid transmembrane transporter activity GO:0016020//GO:0045277//GO:0016021//GO:0031514 membrane//respiratory chain complex IV//integral component of membrane//motile cilium KOG3882 Tetraspanin family integral membrane protein Cluster-8309.46172 BF_2 84.41 1.00 3826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46175 BF_2 324.34 1.97 7159 642912303 XP_008200641.1 1230 1.1e-131 PREDICTED: protein couch potato isoform X3 [Tribolium castaneum] 642912304 XM_008202420.1 406 0 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X4, mRNA -- -- -- -- Q01617 784 2.4e-81 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00168//PF00076 C2 domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.46177 BF_2 446.18 5.30 3806 642912719 XP_008200974.1 2258 3.7e-251 PREDICTED: tyrosine kinase receptor Cad96Ca isoform X1 [Tribolium castaneum] -- -- -- -- -- K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 Q9VBW3 1351 2.2e-147 Tyrosine kinase receptor Cad96Ca OS=Drosophila melanogaster GN=Cad96Ca PE=2 SV=2 PF16622//PF00069//PF06293//PF00028//PF07714 zinc-finger C2H2-type//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Cadherin domain//Protein tyrosine kinase GO:0007156//GO:0006468 homophilic cell adhesion via plasma membrane adhesion molecules//protein phosphorylation GO:0005524//GO:0016773//GO:0005509//GO:0004672//GO:0046872 ATP binding//phosphotransferase activity, alcohol group as acceptor//calcium ion binding//protein kinase activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.46178 BF_2 181.00 2.23 3685 546682477 ERL92400.1 3247 0.0e+00 hypothetical protein D910_09714 [Dendroctonus ponderosae] 820864418 XM_012493351.1 157 8.85991e-74 PREDICTED: Apis florea structural maintenance of chromosomes protein 2 (LOC100863079), transcript variant X1, mRNA K06674 SMC2 structural maintenance of chromosome 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06674 P50533 2622 9.0e-295 Structural maintenance of chromosomes protein 2 OS=Xenopus laevis GN=smc2 PE=1 SV=1 PF13304//PF06470 AAA domain, putative AbiEii toxin, Type IV TA system//SMC proteins Flexible Hinge Domain GO:0051276 chromosome organization GO:0005515//GO:0005524 protein binding//ATP binding GO:0005694 chromosome KOG0933 Structural maintenance of chromosome protein 2 (chromosome condensation complex Condensin, subunit E) Cluster-8309.46181 BF_2 140.55 1.16 5361 642935257 XP_008197935.1 1482 4.9e-161 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 424 9.8e-40 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.46182 BF_2 84.18 1.68 2387 571330972 AHF27418.1 1686 4.9e-185 putative sugar transporter 4_2 [Phaedon cochleariae] 195586810 XM_002083125.1 43 1.34611e-10 Drosophila simulans GD13586 (Dsim\GD13586), mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 P20303 941 4.9e-100 Solute carrier family 2, facilitated glucose transporter member 1 OS=Sus scrofa GN=SLC2A1 PE=2 SV=2 PF00083//PF07690//PF08157 Sugar (and other) transporter//Major Facilitator Superfamily//NUC129 domain GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0569 Permease of the major facilitator superfamily Cluster-8309.46183 BF_2 229.66 5.14 2156 546679304 ERL89791.1 496 4.3e-47 hypothetical protein D910_07152 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03188 Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46184 BF_2 45.00 3.27 863 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46186 BF_2 33.00 80.98 277 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46187 BF_2 129.06 4.04 1624 642915257 XP_008190546.1 1047 4.1e-111 PREDICTED: alpha-tubulin N-acetyltransferase isoform X2 [Tribolium castaneum] -- -- -- -- -- K19573 ATAT1, MEC17 alpha-tubulin N-acetyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19573 Q16Y34 630 3.8e-64 Alpha-tubulin N-acetyltransferase OS=Aedes aegypti GN=AAEL008679 PE=3 SV=1 PF13673//PF05301//PF03494//PF13508//PF00583 Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Beta-amyloid peptide (beta-APP)//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967//GO:0071929 acyl-carrier-protein biosynthetic process//alpha-tubulin acetylation GO:0008080//GO:0019799 N-acetyltransferase activity//tubulin N-acetyltransferase activity GO:0005874//GO:0045298//GO:0016021 microtubule//tubulin complex//integral component of membrane KOG4601 Uncharacterized conserved protein Cluster-8309.46189 BF_2 20.00 5.60 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4619 BF_2 20.71 0.32 2957 270012779 EFA09227.1 1708 1.7e-187 ataxia telangiectasia and Rad3-related protein [Tribolium castaneum] -- -- -- -- -- K06640 ATR serine/threonine-protein kinase ATR http://www.genome.jp/dbget-bin/www_bget?ko:K06640 Q13535 994 4.3e-106 Serine/threonine-protein kinase ATR OS=Homo sapiens GN=ATR PE=1 SV=3 PF00454//PF14010//PF02259 Phosphatidylinositol 3- and 4-kinase//Phosphoenolpyruvate carboxylase//FAT domain GO:0019643//GO:0015977//GO:0006094//GO:0006099 reductive tricarboxylic acid cycle//carbon fixation//gluconeogenesis//tricarboxylic acid cycle GO:0005515//GO:0008964//GO:0016773 protein binding//phosphoenolpyruvate carboxylase activity//phosphotransferase activity, alcohol group as acceptor -- -- KOG0890 Protein kinase of the PI-3 kinase family involved in mitotic growth, DNA repair and meiotic recombination Cluster-8309.46193 BF_2 108.83 0.70 6791 91087949 XP_972541.1 1210 2.2e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.0e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF12763//PF13606//PF13499//PF13833//PF10591//PF13405//PF13202//PF01694//PF00023//PF00036 Cytoskeletal-regulatory complex EF hand//Ankyrin repeat//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Rhomboid family//Ankyrin repeat//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515//GO:0004252 calcium ion binding//protein binding//serine-type endopeptidase activity GO:0016021//GO:0005578 integral component of membrane//proteinaceous extracellular matrix KOG2289 Rhomboid family proteins Cluster-8309.46194 BF_2 154.00 12.05 822 215820608 NP_001135963.1 334 1.0e-28 autophagy related protein Atg12-like protein [Bombyx mori]>gi|213390048|gb|ACJ46063.1| autophagy related protein Atg12-like protein [Bombyx mori] -- -- -- -- -- K08336 ATG12 ubiquitin-like protein ATG12 http://www.genome.jp/dbget-bin/www_bget?ko:K08336 Q9VTU1 274 3.7e-23 Autophagy protein 12-like OS=Drosophila melanogaster GN=Atg12 PE=3 SV=3 PF08727//PF04110 Poliovirus 3A protein like//Ubiquitin-like autophagy protein Apg12 GO:0006508//GO:0006144//GO:0000045 proteolysis//purine nucleobase metabolic process//autophagosome assembly GO:0017111//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0005737//GO:0031379 cytoplasm//RNA-directed RNA polymerase complex KOG3439 Protein conjugation factor involved in autophagy Cluster-8309.46197 BF_2 25.74 2.56 707 478259947 ENN79749.1 609 1.1e-60 hypothetical protein YQE_03805, partial [Dendroctonus ponderosae]>gi|546681497|gb|ERL91574.1| hypothetical protein D910_08904 [Dendroctonus ponderosae] 533121362 XM_005376003.1 92 2.22251e-38 PREDICTED: Chinchilla lanigera glutamine-fructose-6-phosphate transaminase 2 (Gfpt2), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q9Z2Z9 513 6.2e-51 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Mus musculus GN=Gfpt2 PE=2 SV=3 PF01380 SIS domain GO:0005975 carbohydrate metabolic process GO:0030246 carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.46198 BF_2 130.46 0.72 7832 642920114 XP_008192211.1 1223 7.8e-131 PREDICTED: E3 ubiquitin-protein ligase SH3RF1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.6e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF17123//PF09360//PF14634//PF00018//PF14604//PF00097//PF13639 RING-like zinc finger//Iron-binding zinc finger CDGSH type//zinc-RING finger domain//SH3 domain//Variant SH3 domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0046872//GO:0005515//GO:0051537//GO:0008270 metal ion binding//protein binding//2 iron, 2 sulfur cluster binding//zinc ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.46199 BF_2 77.11 3.08 1336 91086881 XP_970132.1 1278 5.6e-138 PREDICTED: RING finger protein 113A [Tribolium castaneum]>gi|270010474|gb|EFA06922.1| hypothetical protein TcasGA2_TC009871 [Tribolium castaneum] 195450055 XM_002072309.1 74 4.35627e-28 Drosophila willistoni GK22373 (Dwil\GK22373), mRNA K13127 RNF113A, CWC24 RING finger protein 113A http://www.genome.jp/dbget-bin/www_bget?ko:K13127 O15541 956 5.0e-102 RING finger protein 113A OS=Homo sapiens GN=RNF113A PE=1 SV=1 PF13639//PF16685//PF11789//PF00097//PF03854//PF00642//PF14634 Ring finger domain//zinc RING finger of MSL2//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//P-11 zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//zinc-RING finger domain -- -- GO:0061630//GO:0046872//GO:0005515//GO:0003723//GO:0008270//GO:0003676 ubiquitin protein ligase activity//metal ion binding//protein binding//RNA binding//zinc ion binding//nucleic acid binding -- -- KOG1813 Predicted E3 ubiquitin ligase Cluster-8309.46200 BF_2 493.43 8.20 2805 478255270 ENN75499.1 1625 6.8e-178 hypothetical protein YQE_08048, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46202 BF_2 149.51 2.14 3212 158294276 XP_001688670.1 383 8.1e-34 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768430547 XM_011558205.1 125 4.74065e-56 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105387473), transcript variant X3, mRNA >gnl|BL_ORD_ID|28135220 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105389571), transcript variant X3, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47194 284 1.0e-23 Synaptobrevin OS=Doryteuthis pealeii PE=1 SV=1 PF00517//PF00963//PF04799//PF07352//PF00957 Retroviral envelope protein//Cohesin domain//fzo-like conserved region//Bacteriophage Mu Gam like protein//Synaptobrevin GO:0008053//GO:0000272//GO:0042262//GO:0016192 mitochondrial fusion//polysaccharide catabolic process//DNA protection//vesicle-mediated transport GO:0030246//GO:0003690//GO:0005198//GO:0003924 carbohydrate binding//double-stranded DNA binding//structural molecule activity//GTPase activity GO:0005741//GO:0016021//GO:0019031 mitochondrial outer membrane//integral component of membrane//viral envelope KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.46203 BF_2 4.00 1.16 431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46204 BF_2 52.45 0.79 3063 642910620 XP_008200030.1 353 2.3e-30 PREDICTED: uncharacterized protein LOC100142225 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.46207 BF_2 66.69 6.51 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46208 BF_2 149.84 1.73 3916 642925647 XP_008194654.1 4485 0.0e+00 PREDICTED: potassium voltage-gated channel subfamily H member 6-like isoform X2 [Tribolium castaneum] 642925646 XM_008196432.1 572 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel subfamily H member 6-like (LOC662676), transcript variant X2, mRNA K04910 KCNH7 potassium voltage-gated channel Eag-related subfamily H member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04910 Q9NS40 1865 5.8e-207 Potassium voltage-gated channel subfamily H member 7 OS=Homo sapiens GN=KCNH7 PE=2 SV=2 PF08447//PF00520//PF00989 PAS fold//Ion transport protein//PAS fold GO:0006811//GO:0055085//GO:0006355 ion transport//transmembrane transport//regulation of transcription, DNA-templated GO:0005515//GO:0005216 protein binding//ion channel activity GO:0016020 membrane KOG0498 K+-channel ERG and related proteins, contain PAS/PAC sensor domain Cluster-8309.46209 BF_2 119.48 1.52 3578 642922915 XP_008200450.1 3937 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 385 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2444 3.8e-274 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF08477//PF06305//PF01926//PF13304//PF02421//PF00071 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function (DUF1049)//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Ferrous iron transport protein B//Ras family GO:0006184//GO:0015684//GO:0007264 obsolete GTP catabolic process//ferrous iron transport//small GTPase mediated signal transduction GO:0005524//GO:0015093//GO:0003924//GO:0005525 ATP binding//ferrous iron transmembrane transporter activity//GTPase activity//GTP binding GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.46210 BF_2 142.12 1.41 4511 91093481 XP_968172.1 1534 3.9e-167 PREDICTED: WD repeat domain phosphoinositide-interacting protein 3 [Tribolium castaneum]>gi|270012665|gb|EFA09113.1| hypothetical protein TcasGA2_TC015973 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CR39 1285 1.2e-139 WD repeat domain phosphoinositide-interacting protein 3 OS=Mus musculus GN=Wdr45b PE=2 SV=2 PF04584//PF00240//PF14560//PF00400//PF03178 Poxvirus A28 family//Ubiquitin family//Ubiquitin-like domain//WD domain, G-beta repeat//CPSF A subunit region GO:0016032 viral process GO:0005515//GO:0003676 protein binding//nucleic acid binding GO:0019031//GO:0005634 viral envelope//nucleus KOG2111 Uncharacterized conserved protein, contains WD40 repeats Cluster-8309.46213 BF_2 764.54 9.58 3626 642940390 XP_008200542.1 2165 2.1e-240 PREDICTED: chitin deacetylase 5 isoform X3 [Tribolium castaneum] 827560342 XM_012695639.1 311 2.14893e-159 PREDICTED: Bombyx mori uncharacterized LOC101740429 (LOC101740429), mRNA -- -- -- -- -- -- -- -- PF01522//PF01607 Polysaccharide deacetylase//Chitin binding Peritrophin-A domain GO:0006030//GO:0006807//GO:0005975 chitin metabolic process//nitrogen compound metabolic process//carbohydrate metabolic process GO:0016810//GO:0008061 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.46217 BF_2 90.75 0.42 9259 642936835 XP_008197838.1 1310 7.5e-141 PREDICTED: calcium-activated potassium channel slowpoke isoform X2 [Tribolium castaneum] 642936834 XM_008199616.1 411 0 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X2, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1258 3.3e-136 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF03493//PF02254//PF01478//PF00520//PF13606//PF07503 Calcium-activated BK potassium channel alpha subunit//TrkA-N domain//Type IV leader peptidase family//Ion transport protein//Ankyrin repeat//HypF finger GO:0055085//GO:0006813//GO:0006811 transmembrane transport//potassium ion transport//ion transport GO:0004190//GO:0015269//GO:0005515//GO:0005216//GO:0008270 aspartic-type endopeptidase activity//calcium-activated potassium channel activity//protein binding//ion channel activity//zinc ion binding GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.46218 BF_2 127.20 1.20 4711 157138068 XP_001657222.1 1584 6.5e-173 AAEL003765-PA, partial [Aedes aegypti]>gi|108880706|gb|EAT44931.1| AAEL003765-PA, partial [Aedes aegypti] 642936834 XM_008199616.1 461 0 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X2, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1492 1.2e-163 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF07503//PF03493 HypF finger//Calcium-activated BK potassium channel alpha subunit GO:0006813 potassium ion transport GO:0000166//GO:0008270//GO:0060072//GO:0015269 nucleotide binding//zinc ion binding//large conductance calcium-activated potassium channel activity//calcium-activated potassium channel activity GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.46220 BF_2 11.00 2.98 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46225 BF_2 69.00 4.53 925 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46226 BF_2 116.60 1.58 3381 189234485 XP_001811926.1 1005 6.4e-106 PREDICTED: uncharacterized protein LOC100142275 isoform X2 [Tribolium castaneum]>gi|270001729|gb|EEZ98176.1| hypothetical protein TcasGA2_TC000605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335//PF02747 Tetraspanin family//Proliferating cell nuclear antigen, C-terminal domain GO:0006275 regulation of DNA replication GO:0003677 DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.46227 BF_2 79.61 1.70 2250 642911000 XP_008193502.1 361 2.0e-31 PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum]>gi|642911002|ref|XP_008193503.1| PREDICTED: uncharacterized protein LOC662221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16113 Enoyl-CoA hydratase/isomerase -- -- GO:0016836 hydro-lyase activity -- -- -- -- Cluster-8309.46228 BF_2 54.87 0.83 3038 642913496 XP_008201037.1 1087 1.8e-115 PREDICTED: uncharacterized protein LOC100142275 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4623 BF_2 8.00 0.72 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46230 BF_2 82.31 1.22 3105 189238048 XP_001811309.1 1728 8.5e-190 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q7ZXF5 876 2.2e-92 Fatty acyl-CoA reductase 1 OS=Xenopus laevis GN=far1 PE=2 SV=1 PF03015//PF01073//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0080019//GO:0016616//GO:0003854//GO:0050662//GO:0003824 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.46232 BF_2 214.84 2.94 3347 642914719 XP_008190322.1 390 1.3e-34 PREDICTED: pH-sensitive chloride channel isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13443//PF02932 Cro/C1-type HTH DNA-binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport GO:0043565 sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.46233 BF_2 880.04 10.50 3792 189237166 XP_974303.2 1329 1.9e-143 PREDICTED: transmembrane protein 198 isoform X1 [Tribolium castaneum]>gi|270007195|gb|EFA03643.1| hypothetical protein TcasGA2_TC013737 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q498W5 483 1.0e-46 Transmembrane protein 198-B OS=Danio rerio GN=tmem198b PE=2 SV=1 PF09207//PF05365 Yeast killer toxin//Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0009405//GO:0006122//GO:0008219 pathogenesis//mitochondrial electron transport, ubiquinol to cytochrome c//cell death -- -- GO:0005750//GO:0005576//GO:0005743 mitochondrial respiratory chain complex III//extracellular region//mitochondrial inner membrane -- -- Cluster-8309.46235 BF_2 2.00 2.09 316 780114121 XP_011676955.1 200 1.3e-13 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q9J569 159 3.1e-10 Putative ankyrin repeat protein FPV162 OS=Fowlpox virus (strain NVSL) GN=FPV162 PE=3 SV=1 PF13606//PF00023//PF05396 Ankyrin repeat//Ankyrin repeat//Phage T7 capsid assembly protein GO:0019069 viral capsid assembly GO:0005515 protein binding -- -- -- -- Cluster-8309.46237 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46238 BF_2 98.82 1.34 3375 765336429 XP_011493101.1 255 5.9e-19 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 222 1.6e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.46239 BF_2 8.32 1.51 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4624 BF_2 39.00 0.51 3495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46240 BF_2 56.10 0.75 3431 765336429 XP_011493101.1 255 6.0e-19 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 222 1.7e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.46241 BF_2 9.00 3.27 401 307181085 EFN68830.1 155 2.8e-08 Transient receptor potential channel pyrexia [Camponotus floridanus] -- -- -- -- -- -- -- -- -- O14974 147 9.6e-09 Protein phosphatase 1 regulatory subunit 12A OS=Homo sapiens GN=PPP1R12A PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.46247 BF_2 257.27 4.58 2637 478251138 ENN71614.1 1171 2.8e-125 hypothetical protein YQE_11713, partial [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q91XA9 609 1.7e-61 Acidic mammalian chitinase OS=Mus musculus GN=Chia PE=1 SV=2 PF00287//PF00704 Sodium / potassium ATPase beta chain//Glycosyl hydrolases family 18 GO:0006814//GO:0006813//GO:0005975 sodium ion transport//potassium ion transport//carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005890 sodium:potassium-exchanging ATPase complex -- -- Cluster-8309.46251 BF_2 1489.69 9.22 7044 642930498 XP_008196429.1 2853 0.0e+00 PREDICTED: CLIP-associating protein isoform X4 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 946 3.8e-100 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF12844//PF01528//PF11640//PF02985 Helix-turn-helix domain//Herpesvirus glycoprotein M//Telomere-length maintenance and DNA damage repair//HEAT repeat GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0005515//GO:0004674//GO:0043565 protein binding//protein serine/threonine kinase activity//sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.46252 BF_2 1721.64 9.78 7652 91089099 XP_971819.1 9261 0.0e+00 PREDICTED: serine/threonine-protein kinase mTOR [Tribolium castaneum]>gi|270011516|gb|EFA07964.1| hypothetical protein TcasGA2_TC005546 [Tribolium castaneum] 242011951 XM_002426662.1 83 2.53024e-32 Pediculus humanus corporis Phosphatidylinositol 3-kinase tor2, putative, mRNA K07203 FRAP FKBP12-rapamycin complex-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K07203 Q9VK45 6979 0.0e+00 Target of rapamycin OS=Drosophila melanogaster GN=Tor PE=1 SV=1 PF00454//PF01602//PF13176//PF02260//PF08771//PF02985//PF02259 Phosphatidylinositol 3- and 4-kinase//Adaptin N terminal region//Tetratricopeptide repeat//FATC domain//Rapamycin binding domain//HEAT repeat//FAT domain GO:0016192//GO:0006886//GO:0016310 vesicle-mediated transport//intracellular protein transport//phosphorylation GO:0016773//GO:0016301//GO:0005524//GO:0008144//GO:0005515 phosphotransferase activity, alcohol group as acceptor//kinase activity//ATP binding//drug binding//protein binding GO:0030117 membrane coat KOG0891 DNA-dependent protein kinase Cluster-8309.46258 BF_2 135.88 1.05 5702 270009582 EFA06030.1 3207 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.84369e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 Q05397 1800 2.9e-199 Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2 PF00069//PF03623//PF07714 Protein kinase domain//Focal adhesion targeting region//Protein tyrosine kinase GO:0007165//GO:0006468//GO:0007172 signal transduction//protein phosphorylation//signal complex assembly GO:0005524//GO:0004713//GO:0004871//GO:0004672 ATP binding//protein tyrosine kinase activity//signal transducer activity//protein kinase activity GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.46259 BF_2 35.20 0.93 1875 642910713 XP_008200528.1 263 3.9e-20 PREDICTED: serine-arginine protein 55-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 Q08170 243 3.3e-19 Serine/arginine-rich splicing factor 4 OS=Homo sapiens GN=SRSF4 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.4626 BF_2 51.83 1.43 1801 91076116 XP_969524.1 1541 2.4e-168 PREDICTED: tRNA modification GTPase GTPBP3, mitochondrial [Tribolium castaneum]>gi|270014577|gb|EFA11025.1| hypothetical protein TcasGA2_TC004613 [Tribolium castaneum] -- -- -- -- -- K03650 mnmE, trmE, MSS1 tRNA modification GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K03650 Q501Z5 1094 6.7e-118 tRNA modification GTPase GTPBP3, mitochondrial OS=Danio rerio GN=gtpbp3 PE=2 SV=1 PF02421//PF00071//PF00005//PF03193//PF08477//PF01926 Ferrous iron transport protein B//Ras family//ABC transporter//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0008033//GO:0015684//GO:0007264 tRNA processing//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0015093//GO:0005524//GO:0016887//GO:0005525//GO:0000166 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//ATPase activity//GTP binding//nucleotide binding GO:0016021 integral component of membrane KOG1191 Mitochondrial GTPase Cluster-8309.46260 BF_2 518.23 5.79 4034 642935257 XP_008197935.1 2067 5.4e-229 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NRG5 1325 2.5e-144 NADPH-dependent diflavin oxidoreductase 1 OS=Xenopus laevis GN=ndor1 PE=2 SV=1 PF12641//PF00175//PF01344//PF07646//PF00667//PF00258 Flavodoxin domain//Oxidoreductase NAD-binding domain//Kelch motif//Kelch motif//FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0005515//GO:0016491//GO:0010181 protein binding//oxidoreductase activity//FMN binding -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.46261 BF_2 49.63 0.43 5163 270013859 EFA10307.1 1822 1.8e-200 hypothetical protein TcasGA2_TC012523 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q6NRG5 1165 1.1e-125 NADPH-dependent diflavin oxidoreductase 1 OS=Xenopus laevis GN=ndor1 PE=2 SV=1 PF00667//PF07646//PF00258//PF01771//PF01344//PF12641//PF00175 FAD binding domain//Kelch motif//Flavodoxin//Herpesvirus alkaline exonuclease//Kelch motif//Flavodoxin domain//Oxidoreductase NAD-binding domain GO:0055114 oxidation-reduction process GO:0005515//GO:0016491//GO:0010181//GO:0003677//GO:0004527 protein binding//oxidoreductase activity//FMN binding//DNA binding//exonuclease activity -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.46262 BF_2 2129.96 54.64 1918 642931467 XP_966826.3 1593 2.4e-174 PREDICTED: proton-coupled folate transporter [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q05B81 249 6.9e-20 Proton-coupled folate transporter OS=Bos taurus GN=SLC46A1 PE=2 SV=1 PF05026//PF07690 Dcp2, box A domain//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0016787//GO:0003723//GO:0030145 hydrolase activity//RNA binding//manganese ion binding GO:0016021 integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.46263 BF_2 169.00 11.14 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46264 BF_2 695.71 4.85 6285 270005549 EFA01997.1 4656 0.0e+00 hypothetical protein TcasGA2_TC007618 [Tribolium castaneum] 642919307 XM_008193597.1 101 2.04686e-42 PREDICTED: Tribolium castaneum signal-induced proliferation-associated 1-like protein 2 (LOC660473), transcript variant X2, mRNA K17702 SIPA1L2, SPAL2 signal-induced proliferation-associated 1 like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17702 Q80TE4 1803 1.4e-199 Signal-induced proliferation-associated 1-like protein 2 OS=Mus musculus GN=Sipa1l2 PE=1 SV=3 PF06005//PF00595//PF04799//PF02145//PF06221 Protein of unknown function (DUF904)//PDZ domain (Also known as DHR or GLGF)//fzo-like conserved region//Rap/ran-GAP//Putative zinc finger motif, C2HC5-type GO:0006355//GO:0008053//GO:0051056//GO:0000917//GO:0043093 regulation of transcription, DNA-templated//mitochondrial fusion//regulation of small GTPase mediated signal transduction//barrier septum assembly//FtsZ-dependent cytokinesis GO:0005096//GO:0003924//GO:0005515//GO:0008270 GTPase activator activity//GTPase activity//protein binding//zinc ion binding GO:0005634//GO:0016021//GO:0005741//GO:0005737 nucleus//integral component of membrane//mitochondrial outer membrane//cytoplasm KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46268 BF_2 17.00 2.49 573 91091214 XP_966756.1 368 7.9e-33 PREDICTED: WD repeat-containing protein 24 [Tribolium castaneum]>gi|270014105|gb|EFA10553.1| hypothetical protein TcasGA2_TC012809 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZX22 179 2.7e-12 WD repeat-containing protein 24 OS=Xenopus laevis GN=wdr24 PE=2 SV=1 -- -- GO:0016558//GO:0007165 protein import into peroxisome matrix//signal transduction GO:0005053 peroxisome matrix targeting signal-2 binding GO:0005781//GO:0005777 obsolete peroxisome targeting signal receptor complex//peroxisome -- -- Cluster-8309.46270 BF_2 75.97 0.40 8252 642920871 XP_008192594.1 3373 0.0e+00 PREDICTED: protein turtle isoform X9 [Tribolium castaneum]>gi|270006125|gb|EFA02573.1| hypothetical protein TcasGA2_TC008291 [Tribolium castaneum] 780702434 XM_011704077.1 443 0 PREDICTED: Wasmannia auropunctata protein turtle (LOC105458610), mRNA -- -- -- -- Q967D7 2984 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF02480//PF07353//PF16656//PF13895//PF07354//PF00041 Tissue factor//Alphaherpesvirus glycoprotein E//Uroplakin II//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain GO:0019497//GO:0007339//GO:0006771//GO:0061024 hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida//riboflavin metabolic process//membrane organization GO:0005515//GO:0003993//GO:0046872 protein binding//acid phosphatase activity//metal ion binding GO:0030176//GO:0016020//GO:0005576 integral component of endoplasmic reticulum membrane//membrane//extracellular region -- -- Cluster-8309.46271 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46272 BF_2 172.00 5.60 1572 478252882 ENN73270.1 1041 2.0e-110 hypothetical protein YQE_10113, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46274 BF_2 1026.16 26.71 1894 642939755 XP_969161.2 2023 3.2e-224 PREDICTED: dnaJ homolog subfamily C member 3 [Tribolium castaneum] -- -- -- -- -- K09523 DNAJC3 DnaJ homolog subfamily C member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09523 Q13217 1117 1.5e-120 DnaJ homolog subfamily C member 3 OS=Homo sapiens GN=DNAJC3 PE=1 SV=1 PF07378//PF13181//PF13174//PF13371//PF00515//PF00836//PF13414//PF13176 Flagellar protein FlbT//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Stathmin family//TPR repeat//Tetratricopeptide repeat GO:0031110//GO:0006402//GO:1902209 regulation of microtubule polymerization or depolymerization//mRNA catabolic process//negative regulation of bacterial-type flagellum assembly GO:0048027//GO:0005515 mRNA 5'-UTR binding//protein binding -- -- KOG0550 Molecular chaperone (DnaJ superfamily) Cluster-8309.46278 BF_2 42.91 0.86 2374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46279 BF_2 684.15 8.18 3784 642919263 XP_008191800.1 2096 2.2e-232 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGM5 1006 2.3e-107 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.46280 BF_2 75.99 0.82 4167 91088223 XP_973543.1 1516 4.4e-165 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Tribolium castaneum]>gi|270011823|gb|EFA08271.1| hypothetical protein TcasGA2_TC005902 [Tribolium castaneum] 645002819 XM_008209794.1 206 5.78577e-101 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X3, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 1276 1.2e-138 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.46281 BF_2 103.37 2.10 2345 91088223 XP_973543.1 1516 2.5e-165 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Tribolium castaneum]>gi|270011823|gb|EFA08271.1| hypothetical protein TcasGA2_TC005902 [Tribolium castaneum] 645002819 XM_008209794.1 206 3.23634e-101 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X3, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 1276 6.9e-139 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0005794//GO:0016021 Golgi apparatus//integral component of membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.46282 BF_2 18.76 1.59 782 642931814 XP_008196744.1 595 5.1e-59 PREDICTED: cytochrome P450 9Z4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q9VG82 369 3.4e-34 Probable cytochrome P450 9f2 OS=Drosophila melanogaster GN=Cyp9f2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.46283 BF_2 226.47 4.71 2298 478256087 ENN76286.1 2279 8.1e-254 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 1431 7.1e-157 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF02568//PF00764//PF00733 Thiamine biosynthesis protein (ThiI)//Arginosuccinate synthase//Asparagine synthase GO:0006522//GO:0008033//GO:0006526//GO:0006529//GO:0006531//GO:0006560 alanine metabolic process//tRNA processing//arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process GO:0004066//GO:0004810//GO:0005524//GO:0004055 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//ATP binding//argininosuccinate synthase activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.46285 BF_2 52.00 5.05 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46286 BF_2 873.36 24.23 1795 642915949 XP_967806.3 1381 8.5e-150 PREDICTED: protein halfway isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 863 4.1e-91 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF15549//PF13855 Leucine Rich Repeat//PGC7/Stella/Dppa3 domain//Leucine rich repeat -- -- GO:0035064//GO:0005515 methylated histone binding//protein binding -- -- -- -- Cluster-8309.46287 BF_2 57.02 0.46 5464 642915951 XP_008190823.1 974 4.1e-102 PREDICTED: protein halfway isoform X2 [Tribolium castaneum]>gi|270004091|gb|EFA00539.1| hypothetical protein TcasGA2_TC003404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 475 1.2e-45 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46288 BF_2 102.65 2.46 2033 642927423 XP_008195266.1 686 3.8e-69 PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum]>gi|642927425|ref|XP_008195267.1| PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46290 BF_2 870.43 7.04 5461 270009582 EFA06030.1 3206 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.76527e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 Q05397 1803 1.2e-199 Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2 PF07714//PF03623//PF00069 Protein tyrosine kinase//Focal adhesion targeting region//Protein kinase domain GO:0006468//GO:0007172//GO:0007165 protein phosphorylation//signal complex assembly//signal transduction GO:0004713//GO:0005524//GO:0004672//GO:0004871 protein tyrosine kinase activity//ATP binding//protein kinase activity//signal transducer activity GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.46291 BF_2 11.39 0.48 1285 170036200 XP_001845953.1 270 4.1e-21 conserved hypothetical protein [Culex quinquefasciatus]>gi|167878751|gb|EDS42134.1| conserved hypothetical protein [Culex quinquefasciatus] 543382501 XM_005534384.1 41 9.25436e-10 PREDICTED: Pseudopodoces humilis bromodomain containing 2 (BRD2), mRNA K08871 BRD2 bromodomain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08871 P13709 249 4.6e-20 Homeotic protein female sterile OS=Drosophila melanogaster GN=fs(1)h PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1474 Transcription initiation factor TFIID, subunit BDF1 and related bromodomain proteins Cluster-8309.46293 BF_2 23.23 0.76 1560 642914933 XP_008190447.1 345 1.0e-29 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.46294 BF_2 643.93 9.40 3152 642914935 XP_008190448.1 756 4.4e-77 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X2 [Tribolium castaneum] 170050238 XM_001859888.1 68 2.25777e-24 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46296 BF_2 337.51 3.60 4207 751778641 XP_011198371.1 1054 1.7e-111 PREDICTED: REST corepressor isoform X2 [Bactrocera dorsalis] 817199620 XM_012420083.1 130 1.03446e-58 PREDICTED: Orussus abietinus uncharacterized LOC105697085 (LOC105697085), transcript variant X3, mRNA -- -- -- -- Q59E36 855 8.1e-90 REST corepressor OS=Drosophila melanogaster GN=CoRest PE=1 SV=2 PF00376 MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG1194 Predicted DNA-binding protein, contains Myb-like, SANT and ELM2 domains Cluster-8309.46298 BF_2 390.00 4.49 3920 91076686 XP_971385.1 1175 1.4e-125 PREDICTED: dnaJ homolog subfamily C member 25 homolog [Tribolium castaneum]>gi|270001878|gb|EEZ98325.1| hypothetical protein TcasGA2_TC000779 [Tribolium castaneum] -- -- -- -- -- K19371 DNAJC25 DnaJ homolog subfamily C member 25 http://www.genome.jp/dbget-bin/www_bget?ko:K19371 Q9VXT2 979 3.2e-104 DnaJ homolog subfamily C member 25 homolog OS=Drosophila melanogaster GN=CG7872 PE=2 SV=1 PF05746//PF02854 DALR anticodon binding domain//MIF4G domain GO:0006420//GO:0006560//GO:0006457//GO:0006525 arginyl-tRNA aminoacylation//proline metabolic process//protein folding//arginine metabolic process GO:0051082//GO:0005515//GO:0004814//GO:0031072//GO:0005524//GO:0003723 unfolded protein binding//protein binding//arginine-tRNA ligase activity//heat shock protein binding//ATP binding//RNA binding -- -- KOG0722 Molecular chaperone (DnaJ superfamily) Cluster-8309.46300 BF_2 429.66 3.58 5307 91081967 XP_967820.1 2574 1.2e-287 PREDICTED: replication factor C subunit 1 [Tribolium castaneum]>gi|270007366|gb|EFA03814.1| hypothetical protein TcasGA2_TC013927 [Tribolium castaneum] 196009296 XM_002114478.1 41 3.90116e-09 Trichoplax adhaerens hypothetical protein, mRNA K10754 RFC1 replication factor C subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10754 P35600 1845 1.6e-204 Replication factor C subunit 1 OS=Drosophila melanogaster GN=Gnf1 PE=1 SV=2 PF00004//PF03462//PF06144//PF07728//PF05496//PF08519//PF00910//PF00472//PF06414 ATPase family associated with various cellular activities (AAA)//PCRF domain//DNA polymerase III, delta subunit//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Replication factor RFC1 C terminal domain//RNA helicase//RF-1 domain//Zeta toxin GO:0006281//GO:0006415//GO:0006260//GO:0006449//GO:0006310 DNA repair//translational termination//DNA replication//regulation of translational termination//DNA recombination GO:0005524//GO:0003747//GO:0003689//GO:0016301//GO:1901363//GO:0016887//GO:0003723//GO:0003677//GO:0016149//GO:0003887//GO:0097159//GO:0009378//GO:0003724 ATP binding//translation release factor activity//DNA clamp loader activity//kinase activity//heterocyclic compound binding//ATPase activity//RNA binding//DNA binding//translation release factor activity, codon specific//DNA-directed DNA polymerase activity//organic cyclic compound binding//four-way junction helicase activity//RNA helicase activity GO:0009360//GO:0009379//GO:0005663//GO:0042575//GO:0005840//GO:0018444//GO:0005737//GO:0005657 DNA polymerase III complex//Holliday junction helicase complex//DNA replication factor C complex//DNA polymerase complex//ribosome//translation release factor complex//cytoplasm//replication fork KOG1968 Replication factor C, subunit RFC1 (large subunit) Cluster-8309.46303 BF_2 429.00 10.20 2047 270003204 EEZ99651.1 1245 5.7e-134 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86BA1 496 1.7e-48 Protein-methionine sulfoxide oxidase Mical OS=Drosophila melanogaster GN=Mical PE=1 SV=1 PF06467//PF00412 MYM-type Zinc finger with FCS sequence motif//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.46304 BF_2 54.64 1.22 2164 270003204 EEZ99651.1 607 5.8e-60 hypothetical protein TcasGA2_TC002408 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- G3MWR8 373 3.2e-34 Protein-methionine sulfoxide oxidase MICAL3 OS=Bos taurus GN=MICAL3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46305 BF_2 43.00 9.46 477 642918586 XP_008199372.1 162 5.1e-09 PREDICTED: protein-methionine sulfoxide oxidase Mical [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46306 BF_2 65.24 0.55 5293 815768419 XP_012231104.1 1519 2.5e-165 PREDICTED: calcium-activated potassium channel slowpoke isoform X12 [Linepithema humile] 642936834 XM_008199616.1 461 0 PREDICTED: Tribolium castaneum calcium-activated potassium channel slowpoke (LOC657078), transcript variant X2, mRNA K04936 KCNMA1 potassium large conductance calcium-activated channel subfamily M alpha member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04936 Q03720 1459 9.3e-160 Calcium-activated potassium channel slowpoke OS=Drosophila melanogaster GN=slo PE=1 SV=3 PF03493//PF07503 Calcium-activated BK potassium channel alpha subunit//HypF finger GO:0006813 potassium ion transport GO:0015269//GO:0008270 calcium-activated potassium channel activity//zinc ion binding GO:0016020 membrane KOG1420 Ca2+-activated K+ channel Slowpoke, alpha subunit Cluster-8309.46307 BF_2 361.30 2.23 7066 642919794 XP_008192070.1 2788 0.0e+00 PREDICTED: coronin-7 isoform X1 [Tribolium castaneum]>gi|270005922|gb|EFA02370.1| hypothetical protein TcasGA2_TC008045 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1118 4.3e-120 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF04851//PF00400 Type III restriction enzyme, res subunit//WD domain, G-beta repeat -- -- GO:0005515//GO:0003677//GO:0016787//GO:0005524 protein binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.46308 BF_2 107.95 4.32 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46311 BF_2 36.00 1.24 1500 270015441 EFA11889.1 189 1.2e-11 hypothetical protein TcasGA2_TC016002 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03079 ARD/ARD' family GO:0055114 oxidation-reduction process GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity -- -- -- -- Cluster-8309.46312 BF_2 57.86 0.53 4893 91088253 XP_966567.1 1655 3.9e-181 PREDICTED: ankyrin repeat and zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270012152|gb|EFA08600.1| hypothetical protein TcasGA2_TC006259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPJ0 627 2.6e-63 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF15306//PF13606//PF06072//PF00023//PF01553 LIN37//Ankyrin repeat//Alphaherpesvirus tegument protein US9//Ankyrin repeat//Acyltransferase GO:0007049//GO:0008152 cell cycle//metabolic process GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0017053//GO:0019033 transcriptional repressor complex//viral tegument KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.46313 BF_2 394.30 3.17 5491 642929086 XP_008195685.1 2031 1.1e-224 PREDICTED: putative transcription factor SOX-15 isoform X1 [Tribolium castaneum] 642929087 XM_008197464.1 219 4.53357e-108 PREDICTED: Tribolium castaneum putative transcription factor SOX-15 (LOC663052), transcript variant X2, mRNA K04495 SOX17 transcription factor SOX17 (SOX group F) http://www.genome.jp/dbget-bin/www_bget?ko:K04495 P40657 448 1.7e-42 Putative transcription factor SOX-15 OS=Drosophila melanogaster GN=Sox15 PE=2 SV=2 PF17066 RBPJ-interacting and tubulin associated protein GO:0051168//GO:0007219 nuclear export//Notch signaling pathway GO:0015631 tubulin binding GO:0045298 tubulin complex KOG0527 HMG-box transcription factor Cluster-8309.46314 BF_2 42.60 0.38 5038 478263926 ENN82092.1 3330 0.0e+00 hypothetical protein YQE_01525, partial [Dendroctonus ponderosae] -- -- -- -- -- K06111 EXOC4, SEC8L1 exocyst complex component 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06111 Q96A65 1435 5.4e-157 Exocyst complex component 4 OS=Homo sapiens GN=EXOC4 PE=1 SV=1 PF04048//PF10392//PF07859//PF08702//PF00326 Sec8 exocyst complex component specific domain//Golgi transport complex subunit 5//alpha/beta hydrolase fold//Fibrinogen alpha/beta chain family//Prolyl oligopeptidase family GO:0015031//GO:0030168//GO:0006508//GO:0051258//GO:0006904//GO:0006891//GO:0007165//GO:0008152 protein transport//platelet activation//proteolysis//protein polymerization//vesicle docking involved in exocytosis//intra-Golgi vesicle-mediated transport//signal transduction//metabolic process GO:0008236//GO:0005102//GO:0030674//GO:0016787 serine-type peptidase activity//receptor binding//protein binding, bridging//hydrolase activity GO:0005577//GO:0017119//GO:0000145 fibrinogen complex//Golgi transport complex//exocyst -- -- Cluster-8309.46317 BF_2 314.74 6.40 2344 270014462 EFA10910.1 282 3.0e-22 hypothetical protein TcasGA2_TC001736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46318 BF_2 362.40 4.53 3634 642911903 XP_008199015.1 1233 2.5e-132 PREDICTED: heat shock factor protein-like isoform X3 [Tribolium castaneum] 642911902 XM_008200793.1 159 6.75341e-75 PREDICTED: Tribolium castaneum heat shock factor protein-like (LOC103314511), transcript variant X4, mRNA K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P22813 658 4.9e-67 Heat shock factor protein OS=Drosophila melanogaster GN=Hsf PE=1 SV=1 PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0627 Heat shock transcription factor Cluster-8309.46319 BF_2 136.39 0.45 13069 270002590 EEZ99037.1 315 2.5e-25 hypothetical protein TcasGA2_TC004911 [Tribolium castaneum] 225543469 NM_001145911.1 123 2.51551e-54 Tribolium castaneum serum response factor (Srf), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46320 BF_2 77.00 4.17 1060 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46321 BF_2 386.21 12.92 1538 642925638 XP_008194650.1 1632 5.7e-179 PREDICTED: putative fatty acyl-CoA reductase CG5065 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 917 1.9e-97 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF05805//PF03015//PF01370//PF01073//PF01118 L6 membrane protein//Male sterility protein//NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0051287//GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding GO:0016021 integral component of membrane KOG1221 Acyl-CoA reductase Cluster-8309.46322 BF_2 145.59 0.79 7994 642920861 XP_008192589.1 3610 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 571 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3120 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF00041//PF07354//PF13895//PF02480//PF07353//PF16656 Tissue factor//Fibronectin type III domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Alphaherpesvirus glycoprotein E//Uroplakin II//Purple acid Phosphatase, N-terminal domain GO:0007339//GO:0019497//GO:0061024//GO:0006771 binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//membrane organization//riboflavin metabolic process GO:0005515//GO:0003993//GO:0046872 protein binding//acid phosphatase activity//metal ion binding GO:0030176//GO:0005576//GO:0016020 integral component of endoplasmic reticulum membrane//extracellular region//membrane -- -- Cluster-8309.46323 BF_2 228.54 1.85 5465 642920861 XP_008192589.1 3667 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 663 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3167 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF02480//PF07353//PF16656//PF13895//PF07354//PF00041//PF01108 Alphaherpesvirus glycoprotein E//Uroplakin II//Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Tissue factor GO:0061024//GO:0006771//GO:0007339//GO:0019497 membrane organization//riboflavin metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0005576//GO:0016020//GO:0030176 extracellular region//membrane//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.46324 BF_2 158.92 1.44 4904 642924106 XP_008194007.1 3057 0.0e+00 PREDICTED: serine/threonine-protein kinase mig-15 isoform X3 [Tribolium castaneum] 642924109 XM_008195787.1 569 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1480 3.2e-162 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF00069//PF06293//PF07463//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//NUMOD4 motif//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0016788//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//hydrolase activity, acting on ester bonds//ATP binding GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.46327 BF_2 364.00 5.61 2999 768421086 XP_011551338.1 1409 8.1e-153 PREDICTED: E3 ubiquitin-protein ligase NRDP1 isoform X2 [Plutella xylostella] -- -- -- -- -- K11981 RNF41, NRDP1 E3 ubiquitin-protein ligase NRDP1 http://www.genome.jp/dbget-bin/www_bget?ko:K11981 Q5FWL3 1121 8.3e-121 E3 ubiquitin-protein ligase NRDP1 OS=Xenopus laevis GN=rnf41 PE=2 SV=1 PF17082//PF13639//PF15965//PF16685//PF03145//PF12861//PF02176//PF11789//PF12678//PF00367//PF04564//PF14634//PF08941//PF00097 Spindle Pole Component 29//Ring finger domain//TRAF-like zinc-finger//zinc RING finger of MSL2//Seven in absentia protein family//Anaphase-promoting complex subunit 11 RING-H2 finger//TRAF-type zinc finger//Zinc-finger of the MIZ type in Nse subunit//RING-H2 zinc finger//phosphotransferase system, EIIB//U-box domain//zinc-RING finger domain//USP8 interacting//Zinc finger, C3HC4 type (RING finger) GO:0006511//GO:0008643//GO:0007275//GO:0016567//GO:0030474 ubiquitin-dependent protein catabolic process//carbohydrate transport//multicellular organismal development//protein ubiquitination//spindle pole body duplication GO:0008270//GO:0005200//GO:0016881//GO:0031386//GO:0008982//GO:0046872//GO:0005515//GO:0004842//GO:0061630 zinc ion binding//structural constituent of cytoskeleton//acid-amino acid ligase activity//protein tag//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//metal ion binding//protein binding//ubiquitin-protein transferase activity//ubiquitin protein ligase activity GO:0009357//GO:0005823//GO:0005856//GO:0005634//GO:0005680 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//central plaque of spindle pole body//cytoskeleton//nucleus//anaphase-promoting complex -- -- Cluster-8309.46329 BF_2 36.12 0.54 3082 478255178 ENN75407.1 459 1.2e-42 hypothetical protein YQE_07958, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK4 165 6.1e-10 Fatty acid-binding protein 12 OS=Mus musculus GN=Fabp12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.46331 BF_2 403.61 3.18 5591 642937261 XP_008198761.1 2852 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270001290|gb|EEZ97737.1| tartan/capricious-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12024 415 1.1e-38 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF01080//PF13855 Leucine Rich Repeat//Presenilin//Leucine rich repeat -- -- GO:0004190//GO:0005515 aspartic-type endopeptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.46333 BF_2 56.41 0.43 5742 642915402 XP_008190599.1 1051 5.0e-111 PREDICTED: nocturnin isoform X1 [Tribolium castaneum] -- -- -- -- -- K18764 CCRN4L nocturnin http://www.genome.jp/dbget-bin/www_bget?ko:K18764 O35710 366 5.6e-33 Nocturnin OS=Mus musculus GN=Ccrn4l PE=1 SV=3 PF03255 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit GO:0006090//GO:0006633 pyruvate metabolic process//fatty acid biosynthetic process GO:0003989 acetyl-CoA carboxylase activity GO:0009317 acetyl-CoA carboxylase complex KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.46338 BF_2 171.01 4.73 1800 642920067 XP_008192192.1 1431 1.4e-155 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58797 434 2.3e-41 Nuclear RNA export factor 1 OS=Coturnix coturnix japonica GN=NXF1 PE=1 SV=1 PF01132//PF03943//PF09162//PF13855//PF02136 Elongation factor P (EF-P) OB domain//TAP C-terminal domain//Tap, RNA-binding//Leucine rich repeat//Nuclear transport factor 2 (NTF2) domain GO:0006414//GO:0006406//GO:0006810//GO:0006448//GO:0051028 translational elongation//mRNA export from nucleus//transport//regulation of translational elongation//mRNA transport GO:0003723//GO:0005515//GO:0003746 RNA binding//protein binding//translation elongation factor activity GO:0005634//GO:0005622//GO:0005840//GO:0005737 nucleus//intracellular//ribosome//cytoplasm -- -- Cluster-8309.4634 BF_2 16.24 0.33 2373 154413468 XP_001579764.1 192 8.4e-12 viral A-type inclusion protein [Trichomonas vaginalis G3]>gi|121913974|gb|EAY18778.1| viral A-type inclusion protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- A6ZYV5 162 1.0e-09 Spindle pole body component 110 OS=Saccharomyces cerevisiae (strain YJM789) GN=SPC110 PE=3 SV=1 PF08941 USP8 interacting GO:0016567 protein ubiquitination GO:0016881//GO:0031386 acid-amino acid ligase activity//protein tag -- -- -- -- Cluster-8309.46341 BF_2 256.98 2.37 4824 478250068 ENN70574.1 5312 0.0e+00 hypothetical protein YQE_12749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TDM6 588 8.5e-59 Disks large homolog 5 OS=Homo sapiens GN=DLG5 PE=1 SV=4 PF15898//PF00595//PF13180//PF04111//PF06156 cGMP-dependent protein kinase interacting domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain//Autophagy protein Apg6//Protein of unknown function (DUF972) GO:0006260//GO:0006914 DNA replication//autophagy GO:0019901//GO:0005515 protein kinase binding//protein binding -- -- KOG3580 Tight junction proteins Cluster-8309.46344 BF_2 35.71 0.58 2869 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46348 BF_2 296.82 7.64 1912 642930331 XP_008196350.1 890 7.8e-93 PREDICTED: ataxin-10 [Tribolium castaneum] -- -- -- -- -- K19323 ATXN10 ataxin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19323 P28658 312 3.4e-27 Ataxin-10 OS=Mus musculus GN=Atxn10 PE=1 SV=2 PF06743//PF01320 FAST kinase-like protein, subdomain 1//Colicin immunity protein / pyocin immunity protein GO:0006955 immune response GO:0004672//GO:0015643 protein kinase activity//toxic substance binding GO:0019814 immunoglobulin complex KOG2676 Uncharacterized conserved protein Cluster-8309.46355 BF_2 12.00 3.21 443 262401269 ACY66537.1 460 1.3e-43 60S ribosomal protein L27 [Scylla paramamosain] 262401268 FJ774816.1 384 0 Scylla paramamosain 60S ribosomal protein L27 mRNA, partial cds K02901 RP-L27e, RPL27 large subunit ribosomal protein L27e http://www.genome.jp/dbget-bin/www_bget?ko:K02901 P61359 349 4.0e-32 60S ribosomal protein L27 OS=Hippocampus comes GN=rpl27 PE=2 SV=2 PF01777 Ribosomal L27e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3418 60S ribosomal protein L27 Cluster-8309.46363 BF_2 91.77 2.14 2083 91082667 XP_966596.1 481 2.3e-45 PREDICTED: uncharacterized protein LOC659832 [Tribolium castaneum]>gi|270014970|gb|EFA11418.1| hypothetical protein TcasGA2_TC013595 [Tribolium castaneum] 642910857 XM_961503.3 132 3.92776e-60 PREDICTED: Tribolium castaneum uncharacterized LOC659832 (LOC659832), mRNA -- -- -- -- -- -- -- -- PF05808 Podoplanin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46364 BF_2 673.88 5.15 5756 91089043 XP_969794.1 4688 0.0e+00 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.11981e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 3142 0.0e+00 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF00400//PF02985//PF06384 WD domain, G-beta repeat//HEAT repeat//Beta-catenin-interacting protein ICAT -- -- GO:0005515//GO:0008013 protein binding//beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.46365 BF_2 6.47 1.06 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46369 BF_2 16.00 3.89 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46371 BF_2 14.67 0.48 1554 91092260 XP_967199.1 670 2.1e-67 PREDICTED: uncharacterized protein C6orf136 [Tribolium castaneum]>gi|270001227|gb|EEZ97674.1| hypothetical protein TcasGA2_TC016219 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SQH8 242 3.6e-19 Uncharacterized protein C6orf136 OS=Homo sapiens GN=C6orf136 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4457 Uncharacterized conserved protein Cluster-8309.46374 BF_2 14.15 1.21 778 546672982 ERL84676.1 236 2.2e-17 hypothetical protein D910_02103 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP7 154 2.9e-09 C-Myc-binding protein OS=Bos taurus GN=MYCBP PE=3 SV=3 PF02330 Mitochondrial glycoprotein -- -- -- -- GO:0005759 mitochondrial matrix -- -- Cluster-8309.46376 BF_2 538.15 3.79 6221 91090504 XP_975968.1 873 2.4e-90 PREDICTED: ribonuclease Oy [Tribolium castaneum]>gi|270013355|gb|EFA09803.1| hypothetical protein TcasGA2_TC011946 [Tribolium castaneum] -- -- -- -- -- K01166 E3.1.27.1 ribonuclease T2 http://www.genome.jp/dbget-bin/www_bget?ko:K01166 Q7M456 400 6.9e-37 Ribonuclease Oy OS=Crassostrea gigas PE=1 SV=1 PF00445 Ribonuclease T2 family -- -- GO:0003723//GO:0033897 RNA binding//ribonuclease T2 activity -- -- KOG1642 Ribonuclease, T2 family Cluster-8309.46377 BF_2 391.41 2.91 5914 91080927 XP_974039.1 6560 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919881|ref|XP_008192108.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|642919883|ref|XP_008192109.1| PREDICTED: E3 ubiquitin-protein ligase UBR2 [Tribolium castaneum]>gi|270005384|gb|EFA01832.1| hypothetical protein TcasGA2_TC007434 [Tribolium castaneum] -- -- -- -- -- K10626 UBR2 E3 ubiquitin-protein ligase UBR2 http://www.genome.jp/dbget-bin/www_bget?ko:K10626 Q8IWV8 3107 0.0e+00 E3 ubiquitin-protein ligase UBR2 OS=Homo sapiens GN=UBR2 PE=1 SV=1 PF01599//PF02617//PF02207//PF04183 Ribosomal protein S27a//ATP-dependent Clp protease adaptor protein ClpS//Putative zinc finger in N-recognin (UBR box)//IucA / IucC family GO:0016567//GO:0006412//GO:0019290//GO:0006826//GO:0030163//GO:0042254 protein ubiquitination//translation//siderophore biosynthetic process//iron ion transport//protein catabolic process//ribosome biogenesis GO:0004842//GO:0008270//GO:0015343//GO:0003735 ubiquitin-protein transferase activity//zinc ion binding//siderophore transmembrane transporter activity//structural constituent of ribosome GO:0005840 ribosome KOG1140 N-end rule pathway, recognition component UBR1 Cluster-8309.46378 BF_2 323.83 1.79 7870 642934473 XP_008197678.1 5341 0.0e+00 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X2 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 3.2e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF06553//PF13606//PF00023//PF00536 BNIP3//Ankyrin repeat//Ankyrin repeat//SAM domain (Sterile alpha motif) GO:0043065 positive regulation of apoptotic process GO:0005515 protein binding GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.46379 BF_2 222.21 1.61 6058 642913051 XP_008201367.1 1799 9.8e-198 PREDICTED: tRNA (guanine(10)-N2)-methyltransferase homolog [Tribolium castaneum] -- -- -- -- -- K15430 TRM11, TRMT11 tRNA (guanine10-N2)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15430 Q6YJI5 1082 5.6e-116 tRNA (guanine(10)-N2)-methyltransferase homolog OS=Gallus gallus GN=TRMT11 PE=2 SV=1 PF13181//PF02384//PF05944//PF08241//PF14863//PF01555//PF13371//PF03602//PF00515//PF02086//PF13414//PF14721 Tetratricopeptide repeat//N-6 DNA Methylase//Phage small terminase subunit//Methyltransferase domain//Alkyl sulfatase dimerisation//DNA methylase//Tetratricopeptide repeat//Conserved hypothetical protein 95//Tetratricopeptide repeat//D12 class N6 adenine-specific DNA methyltransferase//TPR repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term GO:0006306//GO:0019069//GO:0032775//GO:0008152//GO:0031167 DNA methylation//viral capsid assembly//DNA methylation on adenine//metabolic process//rRNA methylation GO:0008170//GO:0008168//GO:0009007//GO:0003677//GO:0004519//GO:0005515//GO:0046983 N-methyltransferase activity//methyltransferase activity//site-specific DNA-methyltransferase (adenine-specific) activity//DNA binding//endonuclease activity//protein binding//protein dimerization activity -- -- KOG2671 Putative RNA methylase Cluster-8309.4638 BF_2 9.00 0.36 1327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46381 BF_2 34.50 1.65 1161 642929593 XP_008195897.1 706 1.0e-71 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 559 4.7e-56 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0909 Peptide:N-glycanase Cluster-8309.46382 BF_2 3.00 121.61 202 189238710 XP_969341.2 341 3.8e-30 PREDICTED: titin [Tribolium castaneum]>gi|270010078|gb|EFA06526.1| hypothetical protein TcasGA2_TC009430 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46383 BF_2 292.06 1.94 6599 642916561 XP_008191701.1 1854 4.5e-204 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U0L2 302 1.7e-25 Ankyrin repeat domain-containing protein 33B OS=Mus musculus GN=Ankrd33b PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46384 BF_2 98.33 4.62 1177 642910330 XP_970349.3 738 2.0e-75 PREDICTED: 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGE0 423 2.8e-40 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3 OS=Xenopus tropicalis GN=ogfod3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46386 BF_2 8.00 1.23 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46387 BF_2 87.42 0.68 5677 189240823 XP_001811917.1 3243 0.0e+00 PREDICTED: ATP-dependent RNA helicase SUV3 homolog, mitochondrial [Tribolium castaneum]>gi|270013711|gb|EFA10159.1| hypothetical protein TcasGA2_TC012348 [Tribolium castaneum] 755880618 XM_005185469.2 352 0 PREDICTED: Musca domestica ATP-dependent RNA helicase SUV3 homolog, mitochondrial (LOC101900390), mRNA K17675 SUPV3L1, SUV3 ATP-dependent RNA helicase SUPV3L1/SUV3 http://www.genome.jp/dbget-bin/www_bget?ko:K17675 Q9VN03 2690 1.8e-302 ATP-dependent RNA helicase SUV3 homolog, mitochondrial OS=Drosophila melanogaster GN=CG9791 PE=2 SV=3 PF12513//PF11965//PF00001 Mitochondrial degradasome RNA helicase subunit C terminal//Domain of unknown function (DUF3479)//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0015994 G-protein coupled receptor signaling pathway//chlorophyll metabolic process GO:0016817//GO:0016851//GO:0003676//GO:0004930//GO:0004386//GO:0005524 hydrolase activity, acting on acid anhydrides//magnesium chelatase activity//nucleic acid binding//G-protein coupled receptor activity//helicase activity//ATP binding GO:0010007//GO:0016021 magnesium chelatase complex//integral component of membrane KOG0953 Mitochondrial RNA helicase SUV3, DEAD-box superfamily Cluster-8309.46389 BF_2 351.99 2.71 5723 642923585 XP_008193571.1 1658 2.1e-181 PREDICTED: run domain Beclin-1 interacting and cysteine-rich containing protein [Tribolium castaneum] -- -- -- -- -- K19330 KIAA0226 run domain Beclin-1 interacting and cysteine-rich containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K19330 Q92622 802 1.5e-83 Run domain Beclin-1 interacting and cysteine-rich containing protein OS=Homo sapiens GN=KIAA0226 PE=1 SV=4 PF14721//PF08506//PF00628 Apoptosis-inducing factor, mitochondrion-associated, C-term//Cse1//PHD-finger GO:0006886 intracellular protein transport GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.4639 BF_2 27.00 0.68 1948 91082495 XP_972789.1 1723 2.0e-189 PREDICTED: SHC SH2 domain-binding protein 1 [Tribolium castaneum]>gi|270007137|gb|EFA03585.1| hypothetical protein TcasGA2_TC013668 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z179 296 2.5e-25 SHC SH2 domain-binding protein 1 OS=Mus musculus GN=Shcbp1 PE=1 SV=1 PF05924 SAMP Motif GO:0016055 Wnt signaling pathway GO:0008013 beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.46392 BF_2 39.91 0.99 1982 270012236 EFA08684.1 705 2.3e-71 hypothetical protein TcasGA2_TC006354 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVV5 386 9.2e-36 Androgen-induced gene 1 protein OS=Homo sapiens GN=AIG1 PE=1 SV=2 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane KOG3989 Beta-2-glycoprotein I Cluster-8309.46394 BF_2 3.00 0.66 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4640 BF_2 3.06 0.32 693 270007072 EFA03520.1 344 5.8e-30 hypothetical protein TcasGA2_TC013522 [Tribolium castaneum] -- -- -- -- -- K18953 NSMAF, FAN factor associated with neutral sphingomyelinase activation http://www.genome.jp/dbget-bin/www_bget?ko:K18953 -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46401 BF_2 59.19 0.57 4611 546674389 ERL85776.1 3567 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 513 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 7.6e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF00069//PF07714//PF12474 Protein kinase domain//Protein tyrosine kinase//Polo kinase kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.46402 BF_2 82.94 1.30 2948 546674389 ERL85776.1 2958 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 768423141 XM_011554159.1 370 0 PREDICTED: Plutella xylostella serine/threonine-protein kinase TAO3 (LOC105384015), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 Q7ZYJ0 1134 2.5e-122 Serine/threonine-protein kinase TAO1-B OS=Xenopus laevis GN=taok1-b PE=2 SV=1 PF12474//PF07714//PF00069 Polo kinase kinase//Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.46403 BF_2 106.48 2.38 2156 270005270 EFA01718.1 1895 2.6e-209 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] 642920293 XM_008194065.1 444 0 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 9-like (LOC664510), transcript variant X2, mRNA K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 Q3U1V8 1312 4.2e-143 Mitogen-activated protein kinase kinase kinase 9 OS=Mus musculus GN=Map3k9 PE=2 SV=2 PF00018//PF14604//PF00069//PF07714 SH3 domain//Variant SH3 domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.46408 BF_2 35.27 0.32 4921 642934471 XP_008197677.1 247 7.3e-18 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46410 BF_2 149.84 1.03 6369 642933926 XP_008197570.1 1635 1.1e-178 PREDICTED: protein Skeletor, isoforms B/C isoform X2 [Tribolium castaneum] 642933925 XM_008199348.1 310 1.36279e-158 PREDICTED: Tribolium castaneum protein Skeletor, isoforms B/C (LOC661990), transcript variant X2, mRNA -- -- -- -- Q9GPJ1 645 2.7e-65 Protein Skeletor, isoforms D/E OS=Drosophila melanogaster GN=Skeletor PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4731 Protein predicted to be involved in spindle matrix formation, contains DM13, DoH, and DOMON domains Cluster-8309.46413 BF_2 34.36 0.35 4357 270009789 EFA06237.1 1463 6.4e-159 hypothetical protein TcasGA2_TC009087 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFD2 206 1.5e-14 Ankyrin repeat and protein kinase domain-containing protein 1 OS=Homo sapiens GN=ANKK1 PE=2 SV=1 PF05509//PF00023//PF13606 TraY domain//Ankyrin repeat//Ankyrin repeat GO:0000746 conjugation GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG4177 Ankyrin Cluster-8309.46415 BF_2 161.98 0.42 16421 157124457 XP_001660469.1 11313 0.0e+00 AAEL009869-PA [Aedes aegypti]>gi|108873980|gb|EAT38205.1| AAEL009869-PA [Aedes aegypti] 665794659 XM_008546814.1 316 1.62841e-161 PREDICTED: Microplitis demolitor low-density lipoprotein receptor-related protein 2 (LOC103569491), mRNA K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 P98158 5576 0.0e+00 Low-density lipoprotein receptor-related protein 2 OS=Rattus norvegicus GN=Lrp2 PE=1 SV=1 PF00008//PF00057//PF07645//PF01731//PF09246 EGF-like domain//Low-density lipoprotein receptor domain class A//Calcium-binding EGF domain//Arylesterase//PHAT GO:0006355 regulation of transcription, DNA-templated GO:0003723//GO:0005509//GO:0004064//GO:0005515 RNA binding//calcium ion binding//arylesterase activity//protein binding GO:0016021 integral component of membrane KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.46416 BF_2 380.43 5.49 3188 91088439 XP_968151.1 778 1.3e-79 PREDICTED: uncharacterized protein LOC656533 [Tribolium castaneum]>gi|270011749|gb|EFA08197.1| hypothetical protein TcasGA2_TC005824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46418 BF_2 114.61 1.13 4541 91083193 XP_972923.1 1404 4.6e-152 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] 347972934 XM_316946.5 74 1.50798e-27 Anopheles gambiae str. PEST AGAP008497-PA (AgaP_AGAP008497) mRNA, partial cds K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q6DG88 837 1.1e-87 Cysteine protease ATG4B OS=Danio rerio GN=atg4b PE=2 SV=2 PF03293 Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006206//GO:0006144//GO:0006810//GO:0006351//GO:0008152//GO:0019083 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transport//transcription, DNA-templated//metabolic process//viral transcription GO:0008233//GO:0003899//GO:0003677 peptidase activity//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46419 BF_2 267.89 2.66 4495 91083193 XP_972923.1 1391 1.5e-150 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] 347972934 XM_316946.5 74 1.49258e-27 Anopheles gambiae str. PEST AGAP008497-PA (AgaP_AGAP008497) mRNA, partial cds K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q5ZIW7 837 1.1e-87 Cysteine protease ATG4A OS=Gallus gallus GN=ATG4A PE=2 SV=1 PF03293 Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006206//GO:0006508//GO:0015031//GO:0019083//GO:0006351//GO:0006914//GO:0006144 pyrimidine nucleobase metabolic process//proteolysis//protein transport//viral transcription//transcription, DNA-templated//autophagy//purine nucleobase metabolic process GO:0008234//GO:0003677//GO:0003899 cysteine-type peptidase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005737 nucleolus//cytoplasm KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46421 BF_2 591.16 10.56 2629 91083193 XP_972923.1 1408 9.2e-153 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] 347972934 XM_316946.5 74 8.68576e-28 Anopheles gambiae str. PEST AGAP008497-PA (AgaP_AGAP008497) mRNA, partial cds K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q6DG88 854 6.6e-90 Cysteine protease ATG4B OS=Danio rerio GN=atg4b PE=2 SV=2 -- -- GO:0006914//GO:0015031//GO:0006508 autophagy//protein transport//proteolysis GO:0008234 cysteine-type peptidase activity GO:0005737 cytoplasm KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46422 BF_2 15.34 0.69 1218 91083193 XP_972923.1 352 1.2e-30 PREDICTED: cysteine protease ATG4B [Tribolium castaneum]>gi|270006970|gb|EFA03418.1| hypothetical protein TcasGA2_TC013405 [Tribolium castaneum] -- -- -- -- -- K08342 ATG4 cysteine protease ATG4 http://www.genome.jp/dbget-bin/www_bget?ko:K08342 Q5ZIW7 192 1.8e-13 Cysteine protease ATG4A OS=Gallus gallus GN=ATG4A PE=2 SV=1 -- -- GO:0006914//GO:0015031//GO:0006508 autophagy//protein transport//proteolysis GO:0008234 cysteine-type peptidase activity GO:0005737 cytoplasm KOG2674 Cysteine protease required for autophagy - Apg4p/Aut2p Cluster-8309.46425 BF_2 513.89 2.13 10402 478249703 ENN70211.1 3709 0.0e+00 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 Q8R420 1191 2.2e-128 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF01225//PF00448//PF03193//PF00005//PF06414//PF13304 Mur ligase family, catalytic domain//SRP54-type protein, GTPase domain//Protein of unknown function, DUF258//ABC transporter//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system GO:0006614//GO:0009058 SRP-dependent cotranslational protein targeting to membrane//biosynthetic process GO:0016887//GO:0016301//GO:0005525//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATP binding//GTPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.46427 BF_2 26.13 0.42 2899 91094333 XP_969230.1 955 3.4e-100 PREDICTED: acyl-protein thioesterase 1 [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 Q5RBR7 628 1.2e-63 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF02230//PF01738//PF00326//PF07859//PF10503//PF05577//PF01764//PF08170 Phospholipase/Carboxylesterase//Dienelactone hydrolase family//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Esterase PHB depolymerase//Serine carboxypeptidase S28//Lipase (class 3)//POPLD (NUC188) domain GO:0006629//GO:0008152//GO:0051252//GO:0008033//GO:0006396//GO:0006508 lipid metabolic process//metabolic process//regulation of RNA metabolic process//tRNA processing//RNA processing//proteolysis GO:0004526//GO:0016787//GO:0008236 ribonuclease P activity//hydrolase activity//serine-type peptidase activity GO:0030677//GO:0005576 ribonuclease P complex//extracellular region KOG2112 Lysophospholipase Cluster-8309.46428 BF_2 133.33 1.17 5035 642910386 XP_969301.3 1715 4.5e-188 PREDICTED: ribonucleases P/MRP protein subunit POP1, partial [Tribolium castaneum] -- -- -- -- -- K06130 LYPLA2 lysophospholipase II http://www.genome.jp/dbget-bin/www_bget?ko:K06130 Q5RBR7 592 3.0e-59 Acyl-protein thioesterase 1 OS=Pongo abelii GN=LYPLA1 PE=2 SV=1 PF01738//PF02230//PF08170//PF00326//PF07859//PF10503//PF05577//PF01764//PF06978 Dienelactone hydrolase family//Phospholipase/Carboxylesterase//POPLD (NUC188) domain//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Esterase PHB depolymerase//Serine carboxypeptidase S28//Lipase (class 3)//Ribonucleases P/MRP protein subunit POP1 GO:0006508//GO:0001682//GO:0051252//GO:0008033//GO:0006396//GO:0008152//GO:0006629 proteolysis//tRNA 5'-leader removal//regulation of RNA metabolic process//tRNA processing//RNA processing//metabolic process//lipid metabolic process GO:0008236//GO:0016787//GO:0004526 serine-type peptidase activity//hydrolase activity//ribonuclease P activity GO:0005576//GO:0030677 extracellular region//ribonuclease P complex KOG2112 Lysophospholipase Cluster-8309.46431 BF_2 5.00 0.80 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46432 BF_2 540.17 4.05 5863 478259801 ENN79629.1 2421 7.1e-270 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 143 8.57547e-66 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P97449 1171 2.6e-126 Aminopeptidase N OS=Mus musculus GN=Anpep PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.46433 BF_2 904.42 4.96 7913 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.1344e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.6e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0008237//GO:0008270//GO:0036459 metallopeptidase activity//zinc ion binding//ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.46434 BF_2 82.77 1.18 3231 478259801 ENN79629.1 1912 4.1e-211 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 146 1.01063e-67 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P16406 992 8.1e-106 Glutamyl aminopeptidase OS=Mus musculus GN=Enpep PE=1 SV=1 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.46436 BF_2 1214.13 14.22 3860 642910971 XP_008193488.1 686 7.1e-69 PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910973|ref|XP_008193489.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910975|ref|XP_008193490.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910977|ref|XP_008193491.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|642910979|ref|XP_008193492.1| PREDICTED: transforming acidic coiled-coil-containing protein 1-like [Tribolium castaneum]>gi|270015145|gb|EFA11593.1| transforming acidic coiled-coil protein [Tribolium castaneum] -- -- -- -- -- K14281 TACC1 transforming acidic coiled-coil-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14281 O75410 289 3.2e-24 Transforming acidic coiled-coil-containing protein 1 OS=Homo sapiens GN=TACC1 PE=1 SV=2 PF07224//PF08702//PF12740 Chlorophyllase//Fibrinogen alpha/beta chain family//Chlorophyllase enzyme GO:0051258//GO:0015994//GO:0015996//GO:0007165//GO:0030168 protein polymerization//chlorophyll metabolic process//chlorophyll catabolic process//signal transduction//platelet activation GO:0047746//GO:0005102//GO:0030674 chlorophyllase activity//receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.46437 BF_2 39.13 2.24 1017 478251178 ENN71654.1 875 2.3e-91 hypothetical protein YQE_11752, partial [Dendroctonus ponderosae] -- -- -- -- -- K18180 COA7, SELRC1, RESA1 cytochrome c oxidase assembly factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18180 Q9W5N0 699 2.4e-72 Cytochrome c oxidase assembly factor 7 homolog OS=Drosophila melanogaster GN=CG13865 PE=1 SV=1 PF13181 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4014 Uncharacterized conserved protein (contains TPR repeat) Cluster-8309.46438 BF_2 620.89 12.12 2431 642912496 XP_008200890.1 1793 1.9e-197 PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912498|ref|XP_008200891.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912500|ref|XP_008200892.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|642912502|ref|XP_008200893.1| PREDICTED: major facilitator superfamily domain-containing protein 6 [Tribolium castaneum]>gi|270002432|gb|EEZ98879.1| hypothetical protein TcasGA2_TC004493 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1LUQ4 218 3.4e-16 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.4644 BF_2 36.06 0.89 1988 646718133 KDR20724.1 912 2.3e-95 DNA polymerase alpha subunit B [Zootermopsis nevadensis] -- -- -- -- -- K02321 POLA2 DNA polymerase alpha subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02321 P33611 674 3.7e-69 DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2 PE=1 SV=2 PF10471//PF04042 Anaphase-promoting complex APC subunit CDC26//DNA polymerase alpha/epsilon subunit B GO:0031145//GO:0006260//GO:0030071 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process//DNA replication//regulation of mitotic metaphase/anaphase transition GO:0003887//GO:0003677 DNA-directed DNA polymerase activity//DNA binding GO:0005680//GO:0042575 anaphase-promoting complex//DNA polymerase complex KOG1625 DNA polymerase alpha-primase complex, polymerase-associated subunit B Cluster-8309.46440 BF_2 479.60 2.57 8082 642926340 XP_008194885.1 3619 0.0e+00 PREDICTED: small G protein signaling modulator 1 isoform X1 [Tribolium castaneum]>gi|270009053|gb|EFA05501.1| hypothetical protein TcasGA2_TC015686 [Tribolium castaneum] 195482092 XM_002101873.1 376 0 Drosophila yakuba GE17884 (Dyak\GE17884), partial mRNA -- -- -- -- Q8BPQ7 2332 8.4e-261 Small G protein signaling modulator 1 OS=Mus musculus GN=Sgsm1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1648 Uncharacterized conserved protein, contains RUN, BRK and TBC domains Cluster-8309.4645 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46450 BF_2 31.00 0.87 1786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46451 BF_2 127.89 3.46 1833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46452 BF_2 52.00 3.14 979 478250567 ENN71060.1 557 1.6e-54 hypothetical protein YQE_12244, partial [Dendroctonus ponderosae]>gi|546681270|gb|ERL91395.1| hypothetical protein D910_08727 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01817 Chorismate mutase type II GO:0046417 chorismate metabolic process -- -- -- -- -- -- Cluster-8309.46453 BF_2 1205.25 64.90 1064 91079780 XP_976161.1 264 1.7e-20 PREDICTED: uncharacterized protein LOC656005 [Tribolium castaneum]>gi|270003312|gb|EEZ99759.1| hypothetical protein TcasGA2_TC002531 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46454 BF_2 51.54 2.46 1163 91079780 XP_976161.1 264 1.8e-20 PREDICTED: uncharacterized protein LOC656005 [Tribolium castaneum]>gi|270003312|gb|EEZ99759.1| hypothetical protein TcasGA2_TC002531 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46456 BF_2 866.83 7.85 4907 91091688 XP_972411.1 1271 1.3e-136 PREDICTED: carbohydrate sulfotransferase 5 [Tribolium castaneum]>gi|270001059|gb|EEZ97506.1| hypothetical protein TcasGA2_TC011350 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QUP4 261 7.1e-21 Carbohydrate sulfotransferase 5 OS=Mus musculus GN=Chst5 PE=2 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.46457 BF_2 56.18 1.16 2306 91081127 XP_976484.1 737 5.2e-75 PREDICTED: protein maelstrom [Tribolium castaneum]>gi|270006444|gb|EFA02892.1| maelstrom [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0W2W6 466 5.7e-45 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.46459 BF_2 98.82 1.82 2555 546681066 ERL91222.1 2100 5.1e-233 hypothetical protein D910_08559 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P07861 812 4.8e-85 Neprilysin OS=Rattus norvegicus GN=Mme PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.46460 BF_2 438.44 5.11 3875 642910870 XP_008193441.1 2744 1.6e-307 PREDICTED: kinesin-like protein Klp10A isoform X1 [Tribolium castaneum] 462310547 APGK01047286.1 86 2.74256e-34 Dendroctonus ponderosae Seq01047296, whole genome shotgun sequence K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 O00139 1655 1.3e-182 Kinesin-like protein KIF2A OS=Homo sapiens GN=KIF2A PE=1 SV=3 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0246 Kinesin-like protein Cluster-8309.46462 BF_2 1766.46 16.95 4647 642922159 XP_008193039.1 2619 6.2e-293 PREDICTED: nostrin isoform X1 [Tribolium castaneum]>gi|270007234|gb|EFA03682.1| hypothetical protein TcasGA2_TC013784 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6WKZ7 419 3.2e-39 Nostrin OS=Mus musculus GN=Nostrin PE=1 SV=2 PF02185//PF00018//PF14604 Hr1 repeat//SH3 domain//Variant SH3 domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG4429 Uncharacterized conserved protein, contains SH3 and FCH domains Cluster-8309.46463 BF_2 5.00 0.79 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46464 BF_2 721.11 9.09 3604 270009986 EFA06434.1 1396 3.1e-151 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.6e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF03359//PF01544//PF02653 Guanylate-kinase-associated protein (GKAP) protein//CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.46468 BF_2 39.67 0.35 5052 270013859 EFA10307.1 1925 2.0e-212 hypothetical protein TcasGA2_TC012523 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PFP6 1230 3.2e-133 NADPH-dependent diflavin oxidoreductase 1 OS=Danio rerio GN=ndor1 PE=2 SV=1 PF01344//PF00175//PF07646//PF00667//PF00258 Kelch motif//Oxidoreductase NAD-binding domain//Kelch motif//FAD binding domain//Flavodoxin GO:0055114 oxidation-reduction process GO:0005515//GO:0016491//GO:0010181 protein binding//oxidoreductase activity//FMN binding -- -- KOG1159 NADP-dependent flavoprotein reductase Cluster-8309.46469 BF_2 49.00 3.17 934 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4647 BF_2 1.88 0.39 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46472 BF_2 125.00 9.31 849 226968625 YP_002808574.1 1066 1.4e-113 NADH dehydrogenase subunit 1 [Scylla paramamosain]>gi|225697861|gb|ACO07228.1| NADH dehydrogenase subunit 1 [Scylla paramamosain] 403311088 JX457150.1 840 0 Scylla paramamosain mitochondrion, complete genome K03878 ND1 NADH-ubiquinone oxidoreductase chain 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03878 P33502 829 1.7e-87 NADH-ubiquinone oxidoreductase chain 1 OS=Anopheles quadrimaculatus GN=ND1 PE=3 SV=1 PF00146 NADH dehydrogenase GO:0055114//GO:0015992//GO:0006814//GO:0006744//GO:0006120 oxidation-reduction process//proton transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0048038//GO:0008137 quinone binding//NADH dehydrogenase (ubiquinone) activity GO:0005739//GO:0016020//GO:0016021//GO:0005886 mitochondrion//membrane//integral component of membrane//plasma membrane KOG4770 NADH dehydrogenase subunit 1 Cluster-8309.46473 BF_2 12.01 1.66 589 332372794 AEE61539.1 226 2.4e-16 unknown [Dendroctonus ponderosae]>gi|478256323|gb|ENN76513.1| hypothetical protein YQE_06964, partial [Dendroctonus ponderosae] -- -- -- -- -- K00849 galK galactokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00849 Q9R0N0 174 1.0e-11 Galactokinase OS=Mus musculus GN=Galk1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46474 BF_2 149.10 3.50 2071 270010719 EFA07167.1 2030 5.5e-225 hypothetical protein TcasGA2_TC010166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH82 622 4.1e-63 SH3 domain-binding protein 5-like OS=Xenopus tropicalis GN=sh3bp5l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2008 BTK-associated SH3-domain binding protein SAB Cluster-8309.46476 BF_2 149.11 0.90 7235 642921434 XP_008192864.1 2906 0.0e+00 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 1324 5.8e-144 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF00876//PF02145//PF00237 Innexin//Rap/ran-GAP//Ribosomal protein L22p/L17e GO:0006412//GO:0042254//GO:0051056 translation//ribosome biogenesis//regulation of small GTPase mediated signal transduction GO:0005096//GO:0003735 GTPase activator activity//structural constituent of ribosome GO:0005921//GO:0005840 gap junction//ribosome KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.46477 BF_2 143.91 1.14 5556 642937240 XP_008198752.1 2533 6.9e-283 PREDICTED: chondroitin sulfate synthase 1 isoform X1 [Tribolium castaneum] 194768964 XM_001966545.1 125 8.23942e-56 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1667 7.4e-184 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF13506//PF01762//PF05679//PF02434 Glycosyl transferase family 21//Galactosyltransferase//Chondroitin N-acetylgalactosaminyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378//GO:0008376 transferase activity, transferring glycosyl groups//galactosyltransferase activity//acetylgalactosaminyltransferase activity GO:0016020//GO:0032580 membrane//Golgi cisterna membrane KOG3588 Chondroitin synthase 1 Cluster-8309.46478 BF_2 5.00 3.66 338 189241624 XP_001807794.1 252 1.3e-19 PREDICTED: chondroitin sulfate synthase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 -- -- -- -- PF05679 Chondroitin N-acetylgalactosaminyltransferase -- -- GO:0008376 acetylgalactosaminyltransferase activity GO:0032580 Golgi cisterna membrane -- -- Cluster-8309.46479 BF_2 375.45 3.09 5364 189241624 XP_001807794.1 2521 1.6e-281 PREDICTED: chondroitin sulfate synthase 1 isoform X2 [Tribolium castaneum] 194768964 XM_001966545.1 131 3.67401e-59 Drosophila ananassae GF22250 (Dana\GF22250), mRNA K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 1685 5.9e-186 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF13506//PF02434//PF05679//PF01762 Glycosyl transferase family 21//Fringe-like//Chondroitin N-acetylgalactosaminyltransferase//Galactosyltransferase GO:0006486 protein glycosylation GO:0008376//GO:0008378//GO:0016757 acetylgalactosaminyltransferase activity//galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020//GO:0032580 membrane//Golgi cisterna membrane KOG3588 Chondroitin synthase 1 Cluster-8309.46481 BF_2 3.00 0.67 475 242002648 XP_002435967.1 291 5.6e-24 60S acidic ribosomal protein P1, putative [Ixodes scapularis]>gi|215499303|gb|EEC08797.1| 60S acidic ribosomal protein P1, putative, partial [Ixodes scapularis] -- -- -- -- -- K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P02402 269 8.1e-23 60S acidic ribosomal protein P1 OS=Artemia salina PE=1 SV=2 -- -- GO:0006414//GO:0042254 translational elongation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1762 60s acidic ribosomal protein P1 Cluster-8309.46482 BF_2 82.00 0.32 11086 642921556 XP_008192422.1 9106 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- K14616 CUBN cubilin http://www.genome.jp/dbget-bin/www_bget?ko:K14616 Q9JLB4 4656 0.0e+00 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.46483 BF_2 26.71 0.90 1522 91090210 XP_967762.1 556 3.3e-54 PREDICTED: UDP-glucuronosyltransferase 2B16 [Tribolium castaneum]>gi|270013463|gb|EFA09911.1| hypothetical protein TcasGA2_TC012062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18569 167 1.8e-10 Ecdysteroid UDP-glucosyltransferase OS=Autographa californica nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.46485 BF_2 955.35 11.42 3787 642928441 XP_008193786.1 225 2.0e-15 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46486 BF_2 7198.06 244.04 1521 642916091 XP_008190884.1 1064 4.1e-113 PREDICTED: alpha-L-fucosidase-like isoform X1 [Tribolium castaneum] 808126062 XM_012310694.1 95 1.05444e-39 PREDICTED: Bombus terrestris alpha-L-fucosidase (LOC100644255), mRNA K01206 FUCA alpha-L-fucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01206 C3YWU0 905 4.7e-96 Alpha-L-fucosidase OS=Branchiostoma floridae GN=BRAFLDRAFT_56888 PE=3 SV=2 PF01546//PF01120 Peptidase family M20/M25/M40//Alpha-L-fucosidase GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016787//GO:0004560 hydrolase activity//alpha-L-fucosidase activity -- -- KOG2276 Metalloexopeptidases Cluster-8309.46487 BF_2 445.24 5.51 3669 189238478 XP_968757.2 855 1.7e-88 PREDICTED: bicaudal D-related protein homolog isoform X2 [Tribolium castaneum] 195590137 XM_002084767.1 68 2.63238e-24 Drosophila simulans GD14464 (Dsim\GD14464), mRNA K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 443 4.2e-42 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF01544//PF01920//PF13851//PF10473 CorA-like Mg2+ transporter protein//Prefoldin subunit//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0055085//GO:0006457//GO:0030001//GO:0048870 transmembrane transport//protein folding//metal ion transport//cell motility GO:0046873//GO:0051082//GO:0042803//GO:0045502//GO:0008134 metal ion transmembrane transporter activity//unfolded protein binding//protein homodimerization activity//dynein binding//transcription factor binding GO:0016020//GO:0016272//GO:0030286//GO:0031514//GO:0005667 membrane//prefoldin complex//dynein complex//motile cilium//transcription factor complex -- -- Cluster-8309.46489 BF_2 397.85 15.16 1385 642910558 XP_008200265.1 1075 2.0e-114 PREDICTED: ras-related protein Rab6 isoform X2 [Tribolium castaneum]>gi|270014377|gb|EFA10825.1| hypothetical protein TcasGA2_TC001600 [Tribolium castaneum] 642910557 XM_008202043.1 281 3.84154e-143 PREDICTED: Tribolium castaneum ras-related protein Rab6 (LOC661182), transcript variant X2, mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 1038 1.6e-111 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF03193//PF08477//PF01926//PF04670//PF02421//PF00025//PF00071 Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Gtr1/RagA G protein conserved region//Ferrous iron transport protein B//ADP-ribosylation factor family//Ras family GO:0015031//GO:0015684//GO:0007264 protein transport//ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0005525//GO:0015093 GTPase activity//GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.46490 BF_2 258.86 2.03 5627 642919894 XP_008192113.1 2193 1.9e-243 PREDICTED: mucin-17 isoform X1 [Tribolium castaneum]>gi|642919896|ref|XP_008192115.1| PREDICTED: mucin-17 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46492 BF_2 1036.16 9.16 5021 91095029 XP_966439.1 854 3.1e-88 PREDICTED: ubiquitin-conjugating enzyme E2 H [Tribolium castaneum]>gi|270014763|gb|EFA11211.1| hypothetical protein TcasGA2_TC005175 [Tribolium castaneum] 462332992 APGK01039128.1 55 6.08707e-17 Dendroctonus ponderosae Seq01039138, whole genome shotgun sequence K10576 UBE2H, UBC8 ubiquitin-conjugating enzyme E2 H http://www.genome.jp/dbget-bin/www_bget?ko:K10576 P62257 751 1.1e-77 Ubiquitin-conjugating enzyme E2 H OS=Mus musculus GN=Ube2h PE=1 SV=1 PF05773 RWD domain -- -- GO:0005515//GO:0016881//GO:0005524 protein binding//acid-amino acid ligase activity//ATP binding -- -- KOG0416 Ubiquitin-protein ligase Cluster-8309.46493 BF_2 822.21 28.76 1483 642928439 XP_008193785.1 1050 1.7e-111 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 751786134 XM_011204132.1 202 3.39468e-99 PREDICTED: Bactrocera dorsalis ras-related protein Rab-8A (LOC105225600), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P35280 874 1.8e-92 Ras-related protein Rab-8A OS=Rattus norvegicus GN=Rab8a PE=1 SV=2 PF00025//PF04670//PF00071//PF10662//PF01926//PF03193//PF08477 ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0006576//GO:0007264//GO:0015031 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.46494 BF_2 426.00 2.82 6602 642916803 XP_008199510.1 1707 5.0e-187 PREDICTED: LON peptidase N-terminal domain and RING finger protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H7 621 1.7e-62 LON peptidase N-terminal domain and RING finger protein 3 OS=Mus musculus GN=Lonrf3 PE=2 SV=1 PF13639//PF16685//PF11789//PF02190//PF00097//PF14634 Ring finger domain//zinc RING finger of MSL2//Zinc-finger of the MIZ type in Nse subunit//ATP-dependent protease La (LON) substrate-binding domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain GO:0006510//GO:0006508 obsolete ATP-dependent proteolysis//proteolysis GO:0046872//GO:0005515//GO:0061630//GO:0004176//GO:0008270 metal ion binding//protein binding//ubiquitin protein ligase activity//ATP-dependent peptidase activity//zinc ion binding -- -- KOG4159 Predicted E3 ubiquitin ligase Cluster-8309.46495 BF_2 183.46 7.42 1322 91078476 XP_968270.1 911 2.0e-95 PREDICTED: ubiquinone biosynthesis protein COQ9, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18587 COQ9 ubiquinone biosynthesis protein COQ9 http://www.genome.jp/dbget-bin/www_bget?ko:K18587 Q8MKN0 559 5.3e-56 Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Drosophila melanogaster GN=Coq9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2969 Uncharacterized conserved protein Cluster-8309.46496 BF_2 91.54 3.01 1558 91078476 XP_968270.1 911 2.3e-95 PREDICTED: ubiquinone biosynthesis protein COQ9, mitochondrial [Tribolium castaneum] -- -- -- -- -- K18587 COQ9 ubiquinone biosynthesis protein COQ9 http://www.genome.jp/dbget-bin/www_bget?ko:K18587 Q8MKN0 559 6.3e-56 Ubiquinone biosynthesis protein COQ9, mitochondrial OS=Drosophila melanogaster GN=Coq9 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2969 Uncharacterized conserved protein Cluster-8309.46498 BF_2 202.12 6.12 1668 642912146 XP_008200825.1 443 4.6e-41 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BQS4 133 1.7e-06 Protein FAM102B OS=Mus musculus GN=Fam102b PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46499 BF_2 856.79 4.07 9085 642929329 XP_008195789.1 5307 0.0e+00 PREDICTED: unconventional myosin-X [Tribolium castaneum] 642929328 XM_008197567.1 514 0 PREDICTED: Tribolium castaneum myosin 22 (LOC662516), mRNA K12559 MYO10 myosin X http://www.genome.jp/dbget-bin/www_bget?ko:K12559 Q9U1M8 1418 9.1e-155 Myosin-I heavy chain OS=Dictyostelium discoideum GN=myoI PE=1 SV=1 PF00788//PF08416//PF00612//PF00784//PF00063 Ras association (RalGDS/AF-6) domain//Phosphotyrosine-binding domain//IQ calmodulin-binding motif//MyTH4 domain//Myosin head (motor domain) GO:0007165 signal transduction GO:0005515//GO:0005524//GO:0003774 protein binding//ATP binding//motor activity GO:0016459//GO:0005856 myosin complex//cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.46500 BF_2 184.20 5.91 1592 642918280 XP_008191442.1 840 4.1e-87 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 642918281 XM_008193221.1 184 3.70223e-89 PREDICTED: Tribolium castaneum UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (LOC655930), transcript variant X2, mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 740 6.6e-77 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13414//PF13176//PF02529//PF13374//PF00515//PF13371//PF13174//PF07721//PF13181 TPR repeat//Tetratricopeptide repeat//Cytochrome B6-F complex subunit 5//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding GO:0009512 cytochrome b6f complex KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.46505 BF_2 9.95 0.63 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46507 BF_2 391.11 7.32 2522 478260870 ENN80509.1 1625 6.1e-178 hypothetical protein YQE_03066, partial [Dendroctonus ponderosae] 195352940 XM_002042933.1 130 6.17e-59 Drosophila sechellia GM16357 (Dsec\GM16357), mRNA K09442 SPDEF SAM pointed domain-containing ETS transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09442 Q9WTP3 564 2.7e-56 SAM pointed domain-containing Ets transcription factor OS=Mus musculus GN=Spdef PE=2 SV=1 PF02198//PF00178 Sterile alpha motif (SAM)/Pointed domain//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3805 ERG and related ETS transcription factors Cluster-8309.46508 BF_2 319.39 2.41 5842 642927212 XP_008195182.1 2270 2.3e-252 PREDICTED: S phase cyclin A-associated protein in the endoplasmic reticulum [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY12 753 7.6e-78 S phase cyclin A-associated protein in the endoplasmic reticulum OS=Homo sapiens GN=SCAPER PE=1 SV=2 PF05955 Equine herpesvirus glycoprotein gp2 GO:0016032 viral process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46509 BF_2 445.70 16.66 1406 546678868 ERL89413.1 1075 2.0e-114 hypothetical protein D910_06780 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 O88531 826 6.2e-87 Palmitoyl-protein thioesterase 1 OS=Mus musculus GN=Ppt1 PE=2 SV=2 PF01674//PF02089 Lipase (class 2)//Palmitoyl protein thioesterase -- -- GO:0098599//GO:0016787 palmitoyl hydrolase activity//hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.46510 BF_2 682.22 8.47 3658 642932512 XP_008197144.1 2807 0.0e+00 PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum]>gi|642932514|ref|XP_008197145.1| PREDICTED: cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 isoform X1 [Tribolium castaneum] 642932517 XM_008198925.1 654 0 PREDICTED: Tribolium castaneum cGMP-dependent protein kinase, isozyme 2 forms cD4/T1/T3A/T3B (LOC662523), transcript variant X4, mRNA K07376 PRKG1 cGMP-dependent protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07376 P32023 2359 2.8e-264 cGMP-dependent protein kinase, isozyme 2 forms cD5/T2 OS=Drosophila melanogaster GN=for PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0614 cGMP-dependent protein kinase Cluster-8309.46511 BF_2 37.54 1.69 1214 546680684 ERL90910.1 475 6.6e-45 hypothetical protein D910_08254 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZL12 135 7.2e-07 Protein phosphatase 1 regulatory subunit 21 OS=Gallus gallus GN=PPP1R21 PE=2 SV=1 PF04799//PF07926//PF10473//PF00170 fzo-like conserved region//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//bZIP transcription factor GO:0006606//GO:0008053//GO:0006355 protein import into nucleus//mitochondrial fusion//regulation of transcription, DNA-templated GO:0008134//GO:0003924//GO:0045502//GO:0043565//GO:0042803//GO:0003700 transcription factor binding//GTPase activity//dynein binding//sequence-specific DNA binding//protein homodimerization activity//transcription factor activity, sequence-specific DNA binding GO:0030286//GO:0016021//GO:0005667//GO:0005741 dynein complex//integral component of membrane//transcription factor complex//mitochondrial outer membrane -- -- Cluster-8309.46513 BF_2 479.32 8.54 2636 642935023 XP_008199910.1 1210 8.4e-130 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 770 3.6e-80 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF11547//PF08925 E3 ubiquitin ligase EDD//Domain of Unknown Function (DUF1907) -- -- GO:0043130 ubiquitin binding GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.46517 BF_2 38.47 0.76 2402 478253832 ENN74124.1 1426 6.9e-155 hypothetical protein YQE_09097, partial [Dendroctonus ponderosae]>gi|546684638|gb|ERL94255.1| hypothetical protein D910_11536 [Dendroctonus ponderosae] 749785289 XM_011148089.1 84 2.1881e-33 PREDICTED: Harpegnathos saltator probable E3 ubiquitin-protein ligase makorin-1 (LOC105187344), mRNA K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q5NU14 740 1.0e-76 Probable E3 ubiquitin-protein ligase makorin-1 OS=Takifugu rubripes GN=mkrn1 PE=2 SV=1 PF00097//PF12678//PF14634//PF13639//PF16685//PF16954//PF00642//PF12861 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain//Ring finger domain//zinc RING finger of MSL2//Haem-transporter, endosomal/lysosomal, haem-responsive gene//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567//GO:0015886 protein ubiquitination//heme transport GO:0015232//GO:0005515//GO:0061630//GO:0004842//GO:0008270//GO:0046872 heme transporter activity//protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.46518 BF_2 77.27 0.49 6927 642931369 XP_008196550.1 7220 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X6 [Tribolium castaneum] 642931368 XM_008198328.1 1020 0 PREDICTED: Tribolium castaneum kinesin 3B (LOC662651), transcript variant X6, mRNA K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5900 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF07353//PF10390//PF05171//PF05014//PF00225//PF00498//PF00959 Uroplakin II//RNA polymerase II elongation factor ELL//Haemin-degrading HemS.ChuX domain//Nucleoside 2-deoxyribosyltransferase//Kinesin motor domain//FHA domain//Phage lysozyme GO:0006206//GO:0016998//GO:0006368//GO:0007017//GO:0061024//GO:0005975//GO:0006826//GO:0007018//GO:0009253//GO:0009159 pyrimidine nucleobase metabolic process//cell wall macromolecule catabolic process//transcription elongation from RNA polymerase II promoter//microtubule-based process//membrane organization//carbohydrate metabolic process//iron ion transport//microtubule-based movement//peptidoglycan catabolic process//deoxyribonucleoside monophosphate catabolic process GO:0008017//GO:0003796//GO:0070694//GO:0003777//GO:0005515//GO:0005524//GO:0050144 microtubule binding//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule motor activity//protein binding//ATP binding//nucleoside deoxyribosyltransferase activity GO:0008023//GO:0030176//GO:0005874//GO:0045298 transcription elongation factor complex//integral component of endoplasmic reticulum membrane//microtubule//tubulin complex KOG0245 Kinesin-like protein Cluster-8309.46521 BF_2 70.72 2.76 1359 170321839 BAG14264.1 334 1.6e-28 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P79953 162 6.0e-10 Ovochymase-2 OS=Xenopus laevis GN=ovch2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.46522 BF_2 1.00 0.49 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46524 BF_2 111.60 0.42 11530 642930915 XP_008196139.1 1612 9.0e-176 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 6.5e-49 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.46526 BF_2 225.59 0.85 11402 642930915 XP_008196139.1 1612 8.9e-176 PREDICTED: limulus clotting factor C-like isoform X2 [Tribolium castaneum]>gi|270012763|gb|EFA09211.1| serine protease P69 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 6.5e-49 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.46528 BF_2 56.21 1.19 2258 478255819 ENN76027.1 844 2.0e-87 hypothetical protein YQE_07403, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.46529 BF_2 6.74 0.31 1183 642937272 XP_008198766.1 570 6.2e-56 PREDICTED: PH and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 462369756 APGK01026098.1 160 5.99298e-76 Dendroctonus ponderosae Seq01026108, whole genome shotgun sequence K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 272 9.1e-23 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.46531 BF_2 52.35 4.50 774 642937272 XP_008198766.1 1042 7.5e-111 PREDICTED: PH and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 642937277 XM_008200547.1 180 2.94531e-87 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X4, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 468 1.1e-45 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF16867 Dimethlysulfonioproprionate lyase -- -- GO:0047869 dimethylpropiothetin dethiomethylase activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.46532 BF_2 38.60 0.65 2766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46533 BF_2 109.96 1.51 3341 642934081 XP_008196456.1 1036 1.6e-109 PREDICTED: phosphatase and actin regulator 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.5e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00957//PF00344 Synaptobrevin//SecY translocase GO:0016192//GO:0015031 vesicle-mediated transport//protein transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.46535 BF_2 763.08 4.35 7625 478249959 ENN70466.1 989 1.0e-103 hypothetical protein YQE_12969, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46539 BF_2 417.65 7.40 2647 642924566 XP_008194346.1 1572 8.9e-172 PREDICTED: endoplasmic reticulum-Golgi intermediate compartment protein 3 isoform X1 [Tribolium castaneum]>gi|270007946|gb|EFA04394.1| hypothetical protein TcasGA2_TC014693 [Tribolium castaneum] 827553572 XM_004929230.2 77 1.87984e-29 PREDICTED: Bombyx mori endoplasmic reticulum-Golgi intermediate compartment protein 3 (LOC101741074), mRNA -- -- -- -- Q803I2 1024 1.3e-109 Endoplasmic reticulum-Golgi intermediate compartment protein 3 OS=Danio rerio GN=ergic3 PE=2 SV=1 PF04976 DMSO reductase anchor subunit (DmsC) GO:0019645 anaerobic electron transport chain -- -- GO:0016021 integral component of membrane KOG2667 COPII vesicle protein Cluster-8309.46544 BF_2 80.97 5.53 900 157138609 XP_001664277.1 735 3.5e-75 AAEL003891-PA [Aedes aegypti]>gi|108880565|gb|EAT44790.1| AAEL003891-PA [Aedes aegypti] -- -- -- -- -- K06515 SLC44A1, CDW92 solute carrier family 44 (choline transporter-like protein), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06515 Q54I48 455 4.2e-44 Choline transporter-like protein 2 OS=Dictyostelium discoideum GN=slc44a2 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.46545 BF_2 84.68 2.83 1541 642937919 XP_008199130.1 921 1.6e-96 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6IR74 295 2.6e-25 Choline transporter-like protein 1 OS=Xenopus laevis GN=slc44a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.46546 BF_2 7.91 0.31 1339 642921367 XP_008192837.1 1377 1.8e-149 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50429 662 6.2e-68 Arylsulfatase B OS=Mus musculus GN=Arsb PE=2 SV=3 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.46548 BF_2 164.85 3.12 2500 642921367 XP_008192837.1 2227 9.4e-248 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50429 840 2.6e-88 Arylsulfatase B OS=Mus musculus GN=Arsb PE=2 SV=3 PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.46551 BF_2 10.89 0.40 1433 642923174 XP_008193640.1 424 6.4e-39 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29RT6 274 6.5e-23 Kinesin-like protein KIF20A OS=Bos taurus GN=KIF20A PE=2 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.46552 BF_2 4.00 0.50 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46556 BF_2 9.02 0.37 1310 630585733 AHZ00135.1 568 1.2e-55 pyruvate dehydrogenase, partial [Spinotectarchus acornutus] 769840408 XM_011633076.1 90 5.44499e-37 PREDICTED: Pogonomyrmex barbatus probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial (LOC105423352), transcript variant X2, mRNA K00161 PDHA, pdhA pyruvate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00161 P52899 485 2.0e-47 Probable pyruvate dehydrogenase E1 component subunit alpha, mitochondrial OS=Caenorhabditis elegans GN=T05H10.6 PE=3 SV=1 PF00676 Dehydrogenase E1 component GO:0008152 metabolic process GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.46561 BF_2 109.80 20.51 511 642920332 XP_975626.2 405 3.6e-37 PREDICTED: fasciculation and elongation protein zeta-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17078//PF04048 SWI5-dependent HO expression protein 3//Sec8 exocyst complex component specific domain GO:0051028//GO:0006904//GO:0015031//GO:0048309 mRNA transport//vesicle docking involved in exocytosis//protein transport//endoplasmic reticulum inheritance -- -- GO:0000145 exocyst KOG3919 Kinesin-associated fasciculation and elongation protein involved in axonal transport Cluster-8309.46562 BF_2 23.60 0.64 1836 91079768 XP_966889.1 356 6.3e-31 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48815 165 3.6e-10 Alcohol dehydrogenase 2 OS=Ceratitis capitata GN=ADH2 PE=3 SV=1 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.46563 BF_2 9.87 0.40 1317 91079768 XP_966889.1 477 4.2e-45 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48815 202 1.3e-14 Alcohol dehydrogenase 2 OS=Ceratitis capitata GN=ADH2 PE=3 SV=1 PF06449//PF00106 Mitochondrial domain of unknown function (DUF1082)//short chain dehydrogenase GO:0008152 metabolic process GO:0016491//GO:0016820 oxidoreductase activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016021//GO:0005739 integral component of membrane//mitochondrion -- -- Cluster-8309.46565 BF_2 229.02 2.37 4326 91078172 XP_967060.1 1454 7.0e-158 PREDICTED: sorting nexin-27 [Tribolium castaneum]>gi|270001364|gb|EEZ97811.1| hypothetical protein TcasGA2_TC000177 [Tribolium castaneum] 573908103 XM_006641708.1 114 8.34221e-50 PREDICTED: Lepisosteus oculatus sorting nexin-27-like (LOC102684965), mRNA K17936 SNX27 sorting nexin-27 http://www.genome.jp/dbget-bin/www_bget?ko:K17936 A5PKA5 1014 3.0e-108 Sorting nexin-27 OS=Bos taurus GN=SNX27 PE=2 SV=1 PF00788//PF01544//PF00787//PF00595//PF13180 Ras association (RalGDS/AF-6) domain//CorA-like Mg2+ transporter protein//PX domain//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0055085//GO:0030001//GO:0007165 transmembrane transport//metal ion transport//signal transduction GO:0005515//GO:0035091//GO:0046873 protein binding//phosphatidylinositol binding//metal ion transmembrane transporter activity GO:0016020 membrane KOG3784 Sorting nexin protein SNX27 Cluster-8309.46567 BF_2 38.76 0.38 4557 642931654 XP_008196673.1 2387 4.8e-266 PREDICTED: rap1 GTPase-activating protein 1 isoform X1 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.49208e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.0e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF02145//PF07836//PF02188//PF13851 Rap/ran-GAP//DmpG-like communication domain//GoLoco motif//Growth-arrest specific micro-tubule binding GO:0019439//GO:0051056//GO:0048870 aromatic compound catabolic process//regulation of small GTPase mediated signal transduction//cell motility GO:0030695//GO:0005096//GO:0016833 GTPase regulator activity//GTPase activator activity//oxo-acid-lyase activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46568 BF_2 667.11 9.97 3087 642939478 XP_008197026.1 2215 2.9e-246 PREDICTED: major facilitator superfamily domain-containing protein 8, partial [Tribolium castaneum] -- -- -- -- -- K12307 MSFD8, CLN7 MFS transporter, ceroid-lipofuscinosis neuronal protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12307 Q8NHS3 830 4.7e-87 Major facilitator superfamily domain-containing protein 8 OS=Homo sapiens GN=MFSD8 PE=1 SV=1 PF07690//PF04923 Major Facilitator Superfamily//Ninjurin GO:0042246//GO:0055085//GO:0007155 tissue regeneration//transmembrane transport//cell adhesion -- -- GO:0016021 integral component of membrane KOG2325 Predicted transporter/transmembrane protein Cluster-8309.46569 BF_2 148.04 2.91 2417 642917000 XP_008199589.1 461 5.5e-43 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 206 8.4e-15 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.46570 BF_2 62.11 2.17 1487 642932834 XP_008197005.1 1294 8.6e-140 PREDICTED: uncharacterized protein LOC663161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46572 BF_2 286.75 2.14 5890 642937382 XP_008198814.1 4353 0.0e+00 PREDICTED: GTPase-activating Rap/Ran-GAP domain-like protein 3 [Tribolium castaneum] 642937381 XM_008200592.1 830 0 PREDICTED: Tribolium castaneum GTPase-activating Rap/Ran-GAP domain-like protein 3 (LOC656074), mRNA -- -- -- -- Q5VVW2 2037 9.9e-227 GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=2 SV=2 PF02145//PF03124 Rap/ran-GAP//EXS family GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46574 BF_2 52.93 0.38 6110 642937382 XP_008198814.1 4353 0.0e+00 PREDICTED: GTPase-activating Rap/Ran-GAP domain-like protein 3 [Tribolium castaneum] 642937381 XM_008200592.1 830 0 PREDICTED: Tribolium castaneum GTPase-activating Rap/Ran-GAP domain-like protein 3 (LOC656074), mRNA -- -- -- -- Q5VVW2 2037 1.0e-226 GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=2 SV=2 PF03124//PF02145 EXS family//Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46575 BF_2 263.32 1.89 6109 642937382 XP_008198814.1 4353 0.0e+00 PREDICTED: GTPase-activating Rap/Ran-GAP domain-like protein 3 [Tribolium castaneum] 642937381 XM_008200592.1 830 0 PREDICTED: Tribolium castaneum GTPase-activating Rap/Ran-GAP domain-like protein 3 (LOC656074), mRNA -- -- -- -- Q5VVW2 2037 1.0e-226 GTPase-activating Rap/Ran-GAP domain-like protein 3 OS=Homo sapiens GN=GARNL3 PE=2 SV=2 PF03124//PF02145 EXS family//Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity GO:0016021 integral component of membrane KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46576 BF_2 2082.83 25.64 3686 642915807 XP_008200086.1 3638 0.0e+00 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 572308789 XM_006620141.1 286 1.72522e-145 PREDICTED: Apis dorsata WD repeat-containing protein 47-like (LOC102670854), mRNA -- -- -- -- Q8CGF6 1106 5.6e-119 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.46577 BF_2 122.90 1.60 3501 329350997 AEB91339.1 2095 2.7e-232 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- -- -- -- -- P18172 1049 2.2e-112 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF02254//PF01266//PF00732//PF05834//PF07992 GMC oxidoreductase//TrkA-N domain//FAD dependent oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase GO:0055114//GO:0006813//GO:0016117 oxidation-reduction process//potassium ion transport//carotenoid biosynthetic process GO:0016491//GO:0016614//GO:0016705//GO:0050660 oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.46581 BF_2 294.26 2.32 5587 642932522 XP_008197149.1 945 9.6e-99 PREDICTED: ribokinase [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 653 2.8e-66 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF04097//PF02066//PF00569//PF04121//PF06701//PF16276 Nup93/Nic96//Metallothionein family 11//Zinc finger, ZZ type//Nuclear pore protein 84 / 107//Mib_herc2//Nucleophosmin C-terminal domain GO:0016567//GO:0006810 protein ubiquitination//transport GO:0005507//GO:0004842//GO:0003676//GO:0008270//GO:0046872 copper ion binding//ubiquitin-protein transferase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005643 nuclear pore -- -- Cluster-8309.46582 BF_2 26.69 0.49 2544 91090496 XP_969212.1 763 5.5e-78 PREDICTED: aminoacylase-1 [Tribolium castaneum]>gi|270013867|gb|EFA10315.1| hypothetical protein TcasGA2_TC012531 [Tribolium castaneum] -- -- -- -- -- K14677 ACY1 aminoacylase http://www.genome.jp/dbget-bin/www_bget?ko:K14677 Q6PTT0 421 1.0e-39 Aminoacylase-1B OS=Rattus norvegicus GN=Acy1b PE=1 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0006520//GO:0006508//GO:0000051//GO:0008152 cellular amino acid metabolic process//proteolysis//obsolete urea cycle intermediate metabolic process//metabolic process GO:0008237//GO:0004046//GO:0016787 metallopeptidase activity//aminoacylase activity//hydrolase activity GO:0005737 cytoplasm KOG2275 Aminoacylase ACY1 and related metalloexopeptidases Cluster-8309.46583 BF_2 322.91 1.72 8156 189241962 XP_968788.2 835 8.0e-86 PREDICTED: remodeling and spacing factor 1-like [Tribolium castaneum] -- -- -- -- -- K11657 RSF1 remodeling and spacing factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11657 Q96T23 382 1.1e-34 Remodeling and spacing factor 1 OS=Homo sapiens GN=RSF1 PE=1 SV=2 PF00628//PF10404//PF01428 PHD-finger//Rad4 beta-hairpin domain 2//AN1-like Zinc finger -- -- GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding -- -- KOG1246 DNA-binding protein jumonji/RBP2/SMCY, contains JmjC domain Cluster-8309.46584 BF_2 3285.27 17.04 8351 642926988 XP_008195092.1 1922 7.3e-212 PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum]>gi|642926990|ref|XP_008195093.1| PREDICTED: uncharacterized protein LOC656611 [Tribolium castaneum] 642926985 XM_008196869.1 122 5.77194e-54 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX27 (LOC103313489), mRNA K01320 F7 coagulation factor VII http://www.genome.jp/dbget-bin/www_bget?ko:K01320 P21902 337 1.9e-29 Proclotting enzyme OS=Tachypleus tridentatus PE=1 SV=1 PF00089//PF02468 Trypsin//Photosystem II reaction centre N protein (psbN) GO:0006508//GO:0015979 proteolysis//photosynthesis GO:0004252 serine-type endopeptidase activity GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.46588 BF_2 271.36 3.70 3356 270001264 EEZ97711.1 2291 4.8e-255 Ras opposite [Tribolium castaneum] 7321217 Y12732.2 114 6.45598e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 1930 1.4e-214 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF05192//PF11744//PF00995 MutS domain III//Aluminium activated malate transporter//Sec1 family GO:0006298//GO:0015743//GO:0006904//GO:0016192 mismatch repair//malate transport//vesicle docking involved in exocytosis//vesicle-mediated transport GO:0005524//GO:0030983 ATP binding//mismatched DNA binding -- -- KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.46590 BF_2 930.81 8.10 5095 270010529 EFA06977.1 4750 0.0e+00 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929423 XM_008197612.1 78 1.01199e-29 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9UIF8 496 4.2e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF01221//PF16866//PF00628//PF00130//PF00439//PF08926 Dynein light chain type 1//PHD-finger//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain//Domain of unknown function (DUF1908) GO:0035556//GO:0007017//GO:0016310//GO:0009069//GO:0006468 intracellular signal transduction//microtubule-based process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0000287//GO:0004674//GO:0005515//GO:0005524 magnesium ion binding//protein serine/threonine kinase activity//protein binding//ATP binding GO:0005875 microtubule associated complex KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.46591 BF_2 71.04 0.78 4105 642912669 XP_008200957.1 3277 0.0e+00 PREDICTED: aminopeptidase N [Tribolium castaneum] 556957556 XM_005989784.1 42 8.37319e-10 PREDICTED: Latimeria chalumnae alanyl (membrane) aminopeptidase (ANPEP), transcript variant X3, mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1579 8.8e-174 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.46593 BF_2 287.69 1.52 8195 642918629 XP_008200387.1 2425 3.4e-270 PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 [Tribolium castaneum] 642918632 XM_008202178.1 276 1.39626e-139 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 6 regulatory subunit 3 (LOC655675), transcript variant X5, mRNA K15501 PPP6R3, SAPS3 serine/threonine-protein phosphatase 6 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15501 Q5F471 1177 7.2e-127 Serine/threonine-protein phosphatase 6 regulatory subunit 3 OS=Gallus gallus GN=PPP6R3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2073 SAP family cell cycle dependent phosphatase-associated protein Cluster-8309.46594 BF_2 33.04 0.40 3781 642928439 XP_008193785.1 891 1.2e-92 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 751786134 XM_011204132.1 190 4.11252e-92 PREDICTED: Bactrocera dorsalis ras-related protein Rab-8A (LOC105225600), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P35280 825 2.2e-86 Ras-related protein Rab-8A OS=Rattus norvegicus GN=Rab8a PE=1 SV=2 PF00025//PF04670//PF00071//PF10662//PF08477//PF03193//PF01926 ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0006576//GO:0007264//GO:0015031 cellular biogenic amine metabolic process//small GTPase mediated signal transduction//protein transport GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.46595 BF_2 35.71 0.43 3769 642928439 XP_008193785.1 891 1.2e-92 PREDICTED: ras-related protein Rab-8A-like [Tribolium castaneum]>gi|270010835|gb|EFA07283.1| hypothetical protein TcasGA2_TC014518 [Tribolium castaneum] 751786134 XM_011204132.1 190 4.09935e-92 PREDICTED: Bactrocera dorsalis ras-related protein Rab-8A (LOC105225600), mRNA K07901 RAB8A, MEL Ras-related protein Rab-8A http://www.genome.jp/dbget-bin/www_bget?ko:K07901 P55258 825 2.2e-86 Ras-related protein Rab-8A OS=Mus musculus GN=Rab8a PE=1 SV=2 PF04670//PF00025//PF10662//PF00071//PF01926//PF08477//PF03193 Gtr1/RagA G protein conserved region//ADP-ribosylation factor family//Ethanolamine utilisation - propanediol utilisation//Ras family//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0007264//GO:0015031//GO:0006576 small GTPase mediated signal transduction//protein transport//cellular biogenic amine metabolic process GO:0003924//GO:0005524//GO:0005525 GTPase activity//ATP binding//GTP binding -- -- KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.46596 BF_2 111.91 3.92 1482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01446 Replication protein GO:0006260 DNA replication GO:0003677 DNA binding GO:0005727 extrachromosomal circular DNA -- -- Cluster-8309.46597 BF_2 91.81 3.83 1291 225543459 NP_001139380.1 271 3.2e-21 dopamine N acetyltransferase isoform 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94521 150 1.4e-08 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46598 BF_2 29.29 0.73 1956 270013391 EFA09839.1 2971 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 275 1.18326e-139 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 286 3.6e-24 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.46600 BF_2 15.00 0.95 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46602 BF_2 749.64 11.78 2949 642922112 XP_008193020.1 768 1.7e-78 PREDICTED: calcium channel flower isoform X2 [Tribolium castaneum]>gi|270007428|gb|EFA03876.1| hypothetical protein TcasGA2_TC014000 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MXW6 393 2.1e-36 Calcium channel flower OS=Drosophila willistoni GN=flower PE=3 SV=2 PF10233//PF03613 Uncharacterized conserved protein CG6151-P//PTS system mannose/fructose/sorbose family IID component GO:0006816//GO:0009401//GO:0048488//GO:0070588 calcium ion transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//synaptic vesicle endocytosis//calcium ion transmembrane transport GO:0005262 calcium channel activity GO:0016021//GO:0030285 integral component of membrane//integral component of synaptic vesicle membrane KOG4085 Uncharacterized conserved protein Cluster-8309.46605 BF_2 191.37 0.73 11314 642925080 XP_008194161.1 4665 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A1 [Tribolium castaneum] 573902448 XM_006638886.1 156 9.84486e-73 PREDICTED: Lepisosteus oculatus lysine-specific demethylase 6A-like (LOC102692642), transcript variant X4, mRNA K14950 ATP13A1 cation-transporting ATPase 13A1 http://www.genome.jp/dbget-bin/www_bget?ko:K14950 Q9HD20 3312 0.0e+00 Manganese-transporting ATPase 13A1 OS=Homo sapiens GN=ATP13A1 PE=1 SV=2 PF13414//PF02388//PF03938//PF00782//PF00515//PF00122//PF13949//PF00102//PF08797//PF13181 TPR repeat//FemAB family//Outer membrane protein (OmpH-like)//Dual specificity phosphatase, catalytic domain//Tetratricopeptide repeat//E1-E2 ATPase//ALIX V-shaped domain binding to HIV//Protein-tyrosine phosphatase//HIRAN domain//Tetratricopeptide repeat GO:0006570//GO:0006470//GO:0009252 tyrosine metabolic process//protein dephosphorylation//peptidoglycan biosynthetic process GO:0004725//GO:0005515//GO:0008138//GO:0016755//GO:0046872//GO:0016818//GO:0003676//GO:0051082//GO:0008270//GO:0000166 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity//transferase activity, transferring amino-acyl groups//metal ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//unfolded protein binding//zinc ion binding//nucleotide binding -- -- KOG0209 P-type ATPase Cluster-8309.46610 BF_2 131.48 2.25 2733 642918280 XP_008191442.1 388 1.8e-34 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] -- -- -- -- -- K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 371 7.0e-34 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.46614 BF_2 242.00 11.14 1196 189238518 XP_001811514.1 354 6.9e-31 PREDICTED: dnaJ homolog subfamily C member 30 [Tribolium castaneum]>gi|270009074|gb|EFA05522.1| hypothetical protein TcasGA2_TC015709 [Tribolium castaneum] -- -- -- -- -- K09515 DNAJB9 DnaJ homolog subfamily B member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K09515 P97554 197 4.6e-14 DnaJ homolog subfamily B member 9 OS=Rattus norvegicus GN=Dnajb9 PE=2 SV=2 PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0016706//GO:0008168 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//methyltransferase activity -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.46617 BF_2 159.61 1.39 5088 546685821 ERL95264.1 1051 4.5e-111 hypothetical protein D910_12530 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04843//PF04931//PF02724//PF01080 Herpesvirus tegument protein, N-terminal conserved region//DNA polymerase phi//CDC45-like protein//Presenilin GO:0006260//GO:0006508//GO:0006270//GO:0006351 DNA replication//proteolysis//DNA replication initiation//transcription, DNA-templated GO:0008233//GO:0003887//GO:0003677//GO:0004190 peptidase activity//DNA-directed DNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0042575//GO:0016021 DNA polymerase complex//integral component of membrane -- -- Cluster-8309.46618 BF_2 50.60 0.66 3488 478251160 ENN71636.1 816 5.4e-84 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46619 BF_2 376.94 7.40 2419 332374250 AEE62266.1 1841 5.3e-203 unknown [Dendroctonus ponderosae]>gi|478251803|gb|ENN72249.1| hypothetical protein YQE_11112, partial [Dendroctonus ponderosae]>gi|546684740|gb|ERL94350.1| hypothetical protein D910_11631 [Dendroctonus ponderosae] -- -- -- -- -- K01102 PDP pyruvate dehydrogenase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01102 Q3UV70 975 5.7e-104 [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial OS=Mus musculus GN=Pdp1 PE=2 SV=1 PF00481//PF03110 Protein phosphatase 2C//SBP domain -- -- GO:0003824//GO:0003677 catalytic activity//DNA binding GO:0005634 nucleus KOG0700 Protein phosphatase 2C/pyruvate dehydrogenase (lipoamide) phosphatase Cluster-8309.46621 BF_2 42.66 0.83 2430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46623 BF_2 189.31 0.53 15368 642914060 XP_008201528.1 14444 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3114 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF14604//PF00018//PF00435//PF00307//PF11616 Variant SH3 domain//SH3 domain//Spectrin repeat//Calponin homology (CH) domain//WD repeat binding protein EZH2 GO:0006479//GO:0006554 protein methylation//lysine catabolic process GO:0018024//GO:0005515 histone-lysine N-methyltransferase activity//protein binding -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.46624 BF_2 116.47 0.76 6677 642914058 XP_008201527.1 6845 0.0e+00 PREDICTED: spectrin alpha chain, non-erythrocytic 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 2022 6.1e-225 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.46625 BF_2 916.02 3.31 11880 642914062 XP_008201529.1 13841 0.0e+00 PREDICTED: spectrin beta chain, non-erythrocytic 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 3138 0.0e+00 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00435//PF14604//PF00018//PF11616//PF00307 Spectrin repeat//Variant SH3 domain//SH3 domain//WD repeat binding protein EZH2//Calponin homology (CH) domain GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0005515//GO:0018024 protein binding//histone-lysine N-methyltransferase activity -- -- KOG0040 Ca2+-binding actin-bundling protein (spectrin), alpha chain (EF-Hand protein superfamily) Cluster-8309.46626 BF_2 333.05 2.20 6612 270002146 EEZ98593.1 6803 0.0e+00 hypothetical protein TcasGA2_TC001109 [Tribolium castaneum] -- -- -- -- -- K06115 SPTB spectrin beta http://www.genome.jp/dbget-bin/www_bget?ko:K06115 Q9NRC6 2022 6.1e-225 Spectrin beta chain, non-erythrocytic 5 OS=Homo sapiens GN=SPTBN5 PE=1 SV=2 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0517 Beta-spectrin Cluster-8309.46628 BF_2 258.47 1.74 6505 642933881 XP_008197550.1 1596 3.6e-174 PREDICTED: protein phosphatase PP2A 55 kDa regulatory subunit isoform X3 [Tribolium castaneum] 817186518 XM_012432341.1 231 1.14687e-114 PREDICTED: Orussus abietinus protein phosphatase PP2A 55 kDa regulatory subunit (LOC105703734), transcript variant X6, mRNA K04354 PPP2R2 serine/threonine-protein phosphatase 2A regulatory subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K04354 P36872 1423 1.7e-155 Protein phosphatase PP2A 55 kDa regulatory subunit OS=Drosophila melanogaster GN=tws PE=2 SV=1 PF00400//PF11093//PF13463//PF13465 WD domain, G-beta repeat//Mitochondrial export protein Som1//Winged helix DNA-binding domain//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0046872//GO:0005515 transcription factor activity, sequence-specific DNA binding//metal ion binding//protein binding GO:0042720//GO:0005667 mitochondrial inner membrane peptidase complex//transcription factor complex KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.46629 BF_2 12.31 1.85 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF01363 Zinc-finger associated domain (zf-AD)//FYVE zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.46632 BF_2 287.51 7.03 1999 478254836 ENN75072.1 973 1.9e-102 hypothetical protein YQE_08385, partial [Dendroctonus ponderosae] -- -- -- -- -- K16795 PAFAH1B2_3 platelet-activating factor acetylhydrolase IB subunit beta/gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16795 Q61206 484 4.0e-47 Platelet-activating factor acetylhydrolase IB subunit beta OS=Mus musculus GN=Pafah1b2 PE=1 SV=2 PF00657 GDSL-like Lipase/Acylhydrolase -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.46634 BF_2 331.38 2.07 6995 642928264 XP_969418.2 1644 1.1e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.5e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.46636 BF_2 34.23 0.45 3445 861616833 KMQ86423.1 1250 2.5e-134 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- Q99315 498 1.7e-48 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF13683//PF00665//PF01165 Integrase core domain//Integrase core domain//Ribosomal protein S21 GO:0042254//GO:0015074//GO:0006412 ribosome biogenesis//DNA integration//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.46638 BF_2 3.00 0.31 695 642913474 XP_008201027.1 155 4.8e-08 PREDICTED: uncharacterized protein LOC664262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.4664 BF_2 1.57 0.35 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46640 BF_2 213.27 1.07 8615 642913474 XP_008201027.1 774 9.9e-79 PREDICTED: uncharacterized protein LOC664262 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 531 6.2e-52 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.46642 BF_2 297.00 5.37 2600 642928291 XP_008195520.1 2436 5.7e-272 PREDICTED: helicase SKI2W [Tribolium castaneum] 510904653 XM_004830813.1 55 3.13305e-17 Babesia equi DEAD/DEAH box helicase domain-containing protein (BEWA_006130) mRNA, complete cds K12599 SKI2, SKIV2L antiviral helicase SKI2 http://www.genome.jp/dbget-bin/www_bget?ko:K12599 Q15477 1385 1.7e-151 Helicase SKI2W OS=Homo sapiens GN=SKIV2L PE=1 SV=3 PF00787//PF04119 PX domain//Heat shock protein 9/12 GO:0006950 response to stress GO:0035091 phosphatidylinositol binding -- -- KOG0947 Cytoplasmic exosomal RNA helicase SKI2, DEAD-box superfamily Cluster-8309.46643 BF_2 452.42 2.95 6699 478256693 ENN76875.1 2011 2.8e-222 hypothetical protein YQE_06716, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PCB5 1066 4.4e-114 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 PF06151//PF05059 Trehalose receptor//Orbivirus VP4 core protein GO:0007187//GO:0050912//GO:0007607 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4425 Uncharacterized conserved protein Cluster-8309.46646 BF_2 1654.74 9.71 7413 91076206 XP_972459.1 2763 2.0e-309 PREDICTED: KN motif and ankyrin repeat domain-containing protein 2 [Tribolium castaneum]>gi|270014552|gb|EFA11000.1| hypothetical protein TcasGA2_TC004585 [Tribolium castaneum] 759076887 XM_011349892.1 70 4.13022e-25 PREDICTED: Cerapachys biroi KN motif and ankyrin repeat domain-containing protein 2-like (LOC105285603), transcript variant X3, mRNA -- -- -- -- Q14678 663 2.6e-67 KN motif and ankyrin repeat domain-containing protein 1 OS=Homo sapiens GN=KANK1 PE=1 SV=3 PF13606//PF00628//PF07649//PF00130//PF00023//PF13939//PF01300//PF01096//PF02150 Ankyrin repeat//PHD-finger//C1-like domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ankyrin repeat//Toxin TisB, type I toxin-antitoxin system//Telomere recombination//Transcription factor S-II (TFIIS)//RNA polymerases M/15 Kd subunit GO:0055114//GO:0035556//GO:0022611//GO:0006144//GO:0006351//GO:0006820//GO:0006206//GO:0009432 oxidation-reduction process//intracellular signal transduction//dormancy process//purine nucleobase metabolic process//transcription, DNA-templated//anion transport//pyrimidine nucleobase metabolic process//SOS response GO:0003899//GO:0003725//GO:0047134//GO:0008270//GO:0005253//GO:0005515//GO:0003677//GO:0003676 DNA-directed RNA polymerase activity//double-stranded RNA binding//protein-disulfide reductase activity//zinc ion binding//anion channel activity//protein binding//DNA binding//nucleic acid binding GO:0005887//GO:0005730 integral component of plasma membrane//nucleolus KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.46647 BF_2 589.00 17.83 1669 642927459 XP_968905.2 1207 1.2e-129 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q3SZJ4 799 1.0e-83 Prostaglandin reductase 1 OS=Bos taurus GN=PTGR1 PE=2 SV=1 PF01370//PF00208//PF00106//PF02826//PF00107 NAD dependent epimerase/dehydratase family//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//short chain dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Zinc-binding dehydrogenase GO:0006520//GO:0055114//GO:0008152 cellular amino acid metabolic process//oxidation-reduction process//metabolic process GO:0016491//GO:0051287//GO:0003824//GO:0050662 oxidoreductase activity//NAD binding//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.46648 BF_2 73.10 0.38 8239 91087319 XP_975585.1 1377 1.1e-148 PREDICTED: solute carrier family 46 member 3-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q5F4B8 256 4.6e-20 Solute carrier family 46 member 3 OS=Gallus gallus GN=SLC46A3 PE=2 SV=1 PF00608//PF02285//PF03869//PF07690 Adenoviral fibre protein (repeat/shaft region)//Cytochrome oxidase c subunit VIII//Arc-like DNA binding domain//Major Facilitator Superfamily GO:0015992//GO:0007155//GO:0055085//GO:0006123//GO:0009405//GO:0019062 proton transport//cell adhesion//transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//pathogenesis//virion attachment to host cell GO:0004129//GO:0003677 cytochrome-c oxidase activity//DNA binding GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.46649 BF_2 13.57 0.31 2118 478250924 ENN71409.1 224 1.5e-15 hypothetical protein YQE_11913, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.46650 BF_2 1429.68 52.38 1429 642934635 XP_008197747.1 237 3.1e-17 PREDICTED: uncharacterized protein LOC103314201 [Tribolium castaneum]>gi|270013491|gb|EFA09939.1| hypothetical protein TcasGA2_TC012092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46651 BF_2 12.02 0.34 1747 642934635 XP_008197747.1 196 2.1e-12 PREDICTED: uncharacterized protein LOC103314201 [Tribolium castaneum]>gi|270013491|gb|EFA09939.1| hypothetical protein TcasGA2_TC012092 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46654 BF_2 1234.08 12.42 4443 642928504 XP_008193818.1 3415 0.0e+00 PREDICTED: endoplasmic reticulum metallopeptidase 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VGW4 1340 4.9e-146 Endoplasmic reticulum metallopeptidase 1 OS=Xenopus laevis GN=ermp1 PE=2 SV=1 PF01546 Peptidase family M20/M25/M40 GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG2194 Aminopeptidases of the M20 family Cluster-8309.46656 BF_2 132.00 3.80 1742 546674232 ERL85660.1 317 2.0e-26 hypothetical protein D910_03077 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46659 BF_2 48.70 0.58 3812 307170013 EFN62483.1 873 1.5e-90 Transposable element P transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q7M3K2 476 6.5e-46 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46660 BF_2 697.88 4.86 6292 642924902 XP_008194090.1 1523 1.0e-165 PREDICTED: serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta isoform X2 [Tribolium castaneum] 504152283 XM_004588332.1 49 1.65278e-13 PREDICTED: Ochotona princeps protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), mRNA K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q9Y5P8 1071 1.1e-114 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta OS=Homo sapiens GN=PPP2R3B PE=1 SV=2 PF13499//PF10591//PF13833//PF13405//PF02022//PF08332//PF00036//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//Integrase Zinc binding domain//Calcium/calmodulin dependent protein kinase II association domain//EF hand//EF hand GO:0007165//GO:0016310//GO:0009069//GO:0006468 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0008270//GO:0005509//GO:0005516//GO:0004683 zinc ion binding//calcium ion binding//calmodulin binding//calmodulin-dependent protein kinase activity GO:0005578 proteinaceous extracellular matrix KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.46664 BF_2 310.24 3.29 4232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46665 BF_2 453.19 6.30 3295 642915652 XP_008190697.1 1571 1.5e-171 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- K09648 IMP2 mitochondrial inner membrane protease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09648 Q969R8 631 6.0e-64 Integrin-alpha FG-GAP repeat-containing protein 2 OS=Homo sapiens GN=ITFG2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.46667 BF_2 2087.75 20.58 4531 270012101 EFA08549.1 2607 1.5e-291 hypothetical protein TcasGA2_TC006204 [Tribolium castaneum] 642931168 XM_964110.3 418 0 PREDICTED: Tribolium castaneum protein tweety (LOC657663), mRNA -- -- -- -- Q9U6L4 1123 7.3e-121 Protein tweety OS=Drosophila melanogaster GN=tty PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.46669 BF_2 52.00 1.79 1503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46670 BF_2 10.37 0.72 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46672 BF_2 5.00 2.56 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08465 Thymidine kinase from Herpesvirus C-terminal GO:0006230//GO:0006206 TMP biosynthetic process//pyrimidine nucleobase metabolic process GO:0004797//GO:0005524 thymidine kinase activity//ATP binding -- -- -- -- Cluster-8309.46673 BF_2 60.43 1.98 1565 642933298 XP_008197360.1 974 1.2e-102 PREDICTED: LOW QUALITY PROTEIN: mucin-17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46677 BF_2 231.00 5.41 2074 91078636 XP_968589.1 446 2.6e-41 PREDICTED: U6 snRNA-associated Sm-like protein LSm5 [Tribolium castaneum]>gi|270004060|gb|EFA00508.1| hypothetical protein TcasGA2_TC003372 [Tribolium castaneum] 242023982 XM_002432365.1 101 6.68402e-43 Pediculus humanus corporis conserved hypothetical protein, mRNA K12624 LSM5 U6 snRNA-associated Sm-like protein LSm5 http://www.genome.jp/dbget-bin/www_bget?ko:K12624 Q2HJH0 382 2.8e-35 U6 snRNA-associated Sm-like protein LSm5 OS=Bos taurus GN=LSM5 PE=3 SV=3 -- -- -- -- -- -- -- -- KOG1775 U6 snRNA-associated Sm-like protein Cluster-8309.4668 BF_2 10.00 0.33 1541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46684 BF_2 54.18 0.61 4018 91089065 XP_970808.1 3130 0.0e+00 PREDICTED: protein brunelleschi [Tribolium castaneum]>gi|642932680|ref|XP_008196943.1| PREDICTED: protein brunelleschi [Tribolium castaneum]>gi|642932683|ref|XP_008196944.1| PREDICTED: protein brunelleschi [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PA97 1499 1.6e-164 Trafficking protein particle complex subunit 9 OS=Xenopus laevis GN=trappc9 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1953 Targeting complex (TRAPP) subunit Cluster-8309.46685 BF_2 4.00 0.51 618 -- -- -- -- -- 761231605 KM881639.1 615 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46686 BF_2 7.31 0.54 858 270011903 EFA08351.1 801 7.3e-83 hypothetical protein TcasGA2_TC005994 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.46688 BF_2 63.00 3.46 1049 642922662 XP_008193267.1 568 9.3e-56 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P29981 416 1.6e-39 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.46689 BF_2 320.45 10.13 1610 642922662 XP_008193267.1 1027 8.5e-109 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q27589 806 1.5e-84 Cytochrome P450 4d2 OS=Drosophila melanogaster GN=Cyp4d2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.46691 BF_2 11.00 2.66 460 642922662 XP_008193267.1 379 3.3e-34 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VMS9 303 8.9e-27 Probable cytochrome P450 4ac1 OS=Drosophila melanogaster GN=Cyp4ac1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005488//GO:0016491//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding//oxidoreductase activity//iron ion binding//heme binding -- -- -- -- Cluster-8309.46692 BF_2 11.55 0.35 1682 642922662 XP_008193267.1 1010 8.4e-107 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q27589 776 4.7e-81 Cytochrome P450 4d2 OS=Drosophila melanogaster GN=Cyp4d2 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.46693 BF_2 673.18 10.59 2947 91092362 XP_971770.1 1234 1.6e-132 PREDICTED: midnolin-A [Tribolium castaneum]>gi|270015714|gb|EFA12162.1| hypothetical protein TcasGA2_TC002312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZWN4 381 5.2e-35 Midnolin-A OS=Xenopus laevis GN=midn-a PE=2 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46695 BF_2 18.00 1.66 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46700 BF_2 192.34 1.73 4950 270013742 EFA10190.1 824 9.1e-85 hypothetical protein TcasGA2_TC012382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46703 BF_2 1230.94 14.86 3752 91088223 XP_973543.1 2732 3.9e-306 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 5 isoform X1 [Tribolium castaneum]>gi|270011823|gb|EFA08271.1| hypothetical protein TcasGA2_TC005902 [Tribolium castaneum] 645002819 XM_008209794.1 290 1.04964e-147 PREDICTED: Nasonia vitripennis polypeptide N-acetylgalactosaminyltransferase 5 (LOC100117924), transcript variant X3, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q6WV17 2284 1.4e-255 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.46704 BF_2 256.15 1.33 8366 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.68933e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF01059//PF10233//PF00472//PF09606//PF00400//PF16692 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Uncharacterized conserved protein CG6151-P//RF-1 domain//ARC105 or Med15 subunit of Mediator complex non-fungal//WD domain, G-beta repeat//Folliculin C-terminal domain GO:0006120//GO:0006449//GO:0006415//GO:0043087//GO:0006357//GO:0055114 mitochondrial electron transport, NADH to ubiquinone//regulation of translational termination//translational termination//regulation of GTPase activity//regulation of transcription from RNA polymerase II promoter//oxidation-reduction process GO:0001104//GO:0003747//GO:0005085//GO:0005515 RNA polymerase II transcription cofactor activity//translation release factor activity//guanyl-nucleotide exchange factor activity//protein binding GO:0016592//GO:0016021//GO:0005840//GO:0018444 mediator complex//integral component of membrane//ribosome//translation release factor complex KOG3154 Uncharacterized conserved protein Cluster-8309.46706 BF_2 504.06 4.34 5145 642933550 XP_008197466.1 3443 0.0e+00 PREDICTED: reversion-inducing cysteine-rich protein with Kazal motifs [Tribolium castaneum] -- -- -- -- -- K17461 RECK, ST15 reversion-inducing-cysteine-rich protein with kazal motifs http://www.genome.jp/dbget-bin/www_bget?ko:K17461 Q9Z0J1 1914 1.6e-212 Reversion-inducing cysteine-rich protein with Kazal motifs OS=Mus musculus GN=Reck PE=2 SV=2 PF07648//PF05375//PF00050//PF02130 Kazal-type serine protease inhibitor domain//Pacifastin inhibitor (LCMII)//Kazal-type serine protease inhibitor domain//Uncharacterized protein family UPF0054 GO:0006364 rRNA processing GO:0004222//GO:0030414//GO:0005515 metalloendopeptidase activity//peptidase inhibitor activity//protein binding -- -- -- -- Cluster-8309.46708 BF_2 226.67 16.94 847 642939420 XP_008200384.1 380 4.7e-34 PREDICTED: phosphatidylinositol 4-kinase type 2-alpha isoform X1 [Tribolium castaneum]>gi|270016503|gb|EFA12949.1| hypothetical protein TcasGA2_TC005069 [Tribolium castaneum] -- -- -- -- -- K13711 PI4K2 phosphatidylinositol 4-kinase type 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13711 Q6DCQ8 244 1.1e-19 Phosphatidylinositol 4-kinase type 2-beta OS=Xenopus laevis GN=pi4k2b PE=2 SV=1 PF14987//PF17050 NADH dehydrogenase 1 alpha subcomplex subunit 3//Altered inheritance of mitochondria 5 GO:0042407 cristae formation -- -- GO:0061617//GO:0005743//GO:0044284//GO:0005747 MICOS complex//mitochondrial inner membrane//mitochondrial crista junction//mitochondrial respiratory chain complex I KOG2381 Phosphatidylinositol 4-kinase Cluster-8309.4671 BF_2 15.59 0.57 1427 817193593 XP_012272264.1 141 4.1e-06 PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193595|ref|XP_012272265.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus]>gi|817193597|ref|XP_012272266.1| PREDICTED: 52 kDa repressor of the inhibitor of the protein kinase-like [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.46710 BF_2 11.26 0.42 1411 642922477 XP_973426.2 404 1.3e-36 PREDICTED: uncharacterized protein LOC662220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46713 BF_2 162.06 1.42 5062 478251563 ENN72025.1 1955 6.6e-216 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A1Z8J0 1065 4.3e-114 CWF19-like protein 1 homolog OS=Drosophila melanogaster GN=CG7741 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.46714 BF_2 42.52 0.70 2832 91081405 XP_972749.1 1031 5.2e-109 PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|642920827|ref|XP_008192575.1| PREDICTED: T-complex protein 11-like protein 1 [Tribolium castaneum]>gi|270005174|gb|EFA01622.1| hypothetical protein TcasGA2_TC007191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ3 432 6.1e-41 T-complex protein 11-like protein 1 OS=Homo sapiens GN=TCP11L1 PE=1 SV=1 PF12689//PF03310 Acid Phosphatase//Caulimovirus DNA-binding protein -- -- GO:0016791//GO:0003677 phosphatase activity//DNA binding -- -- KOG1981 SOK1 kinase belonging to the STE20/SPS1/GC kinase family Cluster-8309.46715 BF_2 324.03 4.38 3383 478252457 ENN72879.1 2104 2.3e-233 hypothetical protein YQE_10449, partial [Dendroctonus ponderosae] -- -- -- -- -- K09531 DNAJC11 DnaJ homolog subfamily C member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09531 Q5U458 1166 5.6e-126 DnaJ homolog subfamily C member 11 OS=Mus musculus GN=Dnajc11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0718 Molecular chaperone (DnaJ superfamily) Cluster-8309.46716 BF_2 269.38 4.06 3064 546683205 ERL93045.1 3551 0.0e+00 hypothetical protein D910_10347 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96JG6 1826 1.5e-202 Syndetin OS=Homo sapiens GN=CCDC132 PE=1 SV=3 PF05531//PF04048//PF08718 Nucleopolyhedrovirus P10 protein//Sec8 exocyst complex component specific domain//Glycolipid transfer protein (GLTP) GO:0015031//GO:0006904//GO:0046836 protein transport//vesicle docking involved in exocytosis//glycolipid transport GO:0051861//GO:0017089 glycolipid binding//glycolipid transporter activity GO:0000145//GO:0005737//GO:0019028 exocyst//cytoplasm//viral capsid KOG2939 Uncharacterized conserved protein Cluster-8309.46718 BF_2 33.44 1.20 1457 270004864 EFA01312.1 2091 3.2e-232 baboon, partial [Tribolium castaneum] 589944031 XM_006984651.1 98 2.16876e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 P36897 1480 9.4e-163 TGF-beta receptor type-1 OS=Homo sapiens GN=TGFBR1 PE=1 SV=1 PF08515//PF00069//PF01064//PF07714 Transforming growth factor beta type I GS-motif//Protein kinase domain//Activin types I and II receptor domain//Protein tyrosine kinase GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004675//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.46719 BF_2 5.00 4.01 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46720 BF_2 26.00 5.55 483 826449982 XP_012532058.1 135 6.9e-06 PREDICTED: TGF-beta receptor type-1 isoform X2 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064 Activin types I and II receptor domain GO:0016310//GO:0009069//GO:0007178 phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.46721 BF_2 13.00 1.25 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46722 BF_2 159.22 3.17 2387 270004864 EFA01312.1 2073 6.5e-230 baboon, partial [Tribolium castaneum] 589944031 XM_006984651.1 98 3.58714e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 P36897 1473 1.0e-161 TGF-beta receptor type-1 OS=Homo sapiens GN=TGFBR1 PE=1 SV=1 PF07714//PF01064//PF00069//PF08515//PF02790 Protein tyrosine kinase//Activin types I and II receptor domain//Protein kinase domain//Transforming growth factor beta type I GS-motif//Cytochrome C oxidase subunit II, transmembrane domain GO:0009069//GO:0006468//GO:0016310//GO:0007178//GO:0022900 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway//electron transport chain GO:0005524//GO:0004672//GO:0004675 ATP binding//protein kinase activity//transmembrane receptor protein serine/threonine kinase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.46725 BF_2 39.50 1.38 1484 642915222 XP_008190529.1 1973 1.6e-218 PREDICTED: TGF-beta receptor type-1 isoform X1 [Tribolium castaneum] 589944031 XM_006984651.1 98 2.20994e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 O46680 1455 7.6e-160 TGF-beta receptor type-1 OS=Bos taurus GN=TGFBR1 PE=2 SV=1 PF08515//PF01064//PF00069//PF07714 Transforming growth factor beta type I GS-motif//Activin types I and II receptor domain//Protein kinase domain//Protein tyrosine kinase GO:0007178//GO:0016310//GO:0006468//GO:0009069 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.46732 BF_2 583.38 4.82 5347 642915949 XP_967806.3 974 4.0e-102 PREDICTED: protein halfway isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 475 1.2e-45 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46733 BF_2 53.03 0.65 3714 91076832 XP_974636.1 3605 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 168 6.8549e-80 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 670 2.0e-68 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0000166//GO:0005524 protein kinase activity//nucleotide binding//ATP binding -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.46734 BF_2 161.00 2.81 2688 642929118 XP_008195696.1 834 3.4e-86 PREDICTED: uncharacterized protein LOC100142378 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42893 530 2.5e-52 Endothelin-converting enzyme 1 OS=Rattus norvegicus GN=Ece1 PE=1 SV=2 PF05649//PF01431 Peptidase family M13//Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.46735 BF_2 355.16 2.69 5815 546677823 ERL88580.1 3317 0.0e+00 hypothetical protein D910_05965 [Dendroctonus ponderosae] 562831337 XM_006145090.1 42 1.1892e-09 PREDICTED: Tupaia chinensis tripartite motif containing 24 (TRIM24), mRNA K08883 TRIM33, TIF1G tripartite motif-containing protein 33 http://www.genome.jp/dbget-bin/www_bget?ko:K08883 Q56R14 487 5.3e-47 E3 ubiquitin-protein ligase TRIM33 OS=Xenopus laevis GN=trim33 PE=1 SV=1 PF00439//PF13639//PF00628//PF14634//PF00643//PF00097//PF01361 Bromodomain//Ring finger domain//PHD-finger//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger)//Tautomerase enzyme GO:0006725 cellular aromatic compound metabolic process GO:0046872//GO:0005515//GO:0016853//GO:0008270 metal ion binding//protein binding//isomerase activity//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.46736 BF_2 174.00 2.28 3484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08025 Spider antimicrobial peptide GO:0019836 hemolysis by symbiont of host erythrocytes -- -- GO:0005576 extracellular region -- -- Cluster-8309.46739 BF_2 45.56 0.61 3403 189239692 XP_967139.2 1433 1.5e-155 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 65 1.13505e-22 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 929 1.7e-98 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF01080//PF00957//PF03293 Presenilin//Synaptobrevin//Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006206//GO:0006351//GO:0019083//GO:0006144//GO:0016192 pyrimidine nucleobase metabolic process//transcription, DNA-templated//viral transcription//purine nucleobase metabolic process//vesicle-mediated transport GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0005730//GO:0016021 nucleolus//integral component of membrane KOG2736 Presenilin Cluster-8309.46740 BF_2 78.91 1.07 3382 189239692 XP_967139.2 1433 1.5e-155 PREDICTED: presenilin homolog [Tribolium castaneum] 507629623 XM_004698694.1 65 1.12798e-22 PREDICTED: Echinops telfairi presenilin 1 (PSEN1), transcript variant X2, mRNA K04505 PSEN1, PS1 presenilin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04505 Q4JIM4 929 1.7e-98 Presenilin-1 OS=Gallus gallus GN=PSEN1 PE=1 SV=1 PF01080//PF00957//PF03293 Presenilin//Synaptobrevin//Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006144//GO:0016192//GO:0006351//GO:0019083//GO:0006206 purine nucleobase metabolic process//vesicle-mediated transport//transcription, DNA-templated//viral transcription//pyrimidine nucleobase metabolic process GO:0003899//GO:0004190//GO:0003677 DNA-directed RNA polymerase activity//aspartic-type endopeptidase activity//DNA binding GO:0016021//GO:0005730 integral component of membrane//nucleolus KOG2736 Presenilin Cluster-8309.46745 BF_2 217.00 10.42 1158 478253972 ENN74264.1 285 6.7e-23 hypothetical protein YQE_09236, partial [Dendroctonus ponderosae]>gi|546674823|gb|ERL86109.1| hypothetical protein D910_03523 [Dendroctonus ponderosae] 749731967 XM_011139388.1 34 6.48064e-06 PREDICTED: Harpegnathos saltator UPF0547 protein C16orf87-like (LOC105182147), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF07882//PF07851//PF08070 L-fucose isomerase, second N-terminal domain//TMPIT-like protein//DTHCT (NUC029) region GO:0006013//GO:0006265//GO:0006000//GO:0006004 mannose metabolic process//DNA topological change//fructose metabolic process//fucose metabolic process GO:0003918//GO:0005524//GO:0003677//GO:0008736 DNA topoisomerase type II (ATP-hydrolyzing) activity//ATP binding//DNA binding//L-fucose isomerase activity GO:0005737//GO:0005634//GO:0016021 cytoplasm//nucleus//integral component of membrane -- -- Cluster-8309.46746 BF_2 351.79 4.61 3479 642928007 XP_008200118.1 1675 1.3e-183 PREDICTED: solute carrier family 35, member F5 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15289 SLC35F5 solute carrier family 35, member F5 http://www.genome.jp/dbget-bin/www_bget?ko:K15289 A6QL92 863 7.9e-91 Solute carrier family 35 member F5 OS=Bos taurus GN=SLC35F5 PE=2 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2765 Predicted membrane protein Cluster-8309.46748 BF_2 478.94 13.43 1779 646709836 KDR15525.1 1383 4.9e-150 Vacuolar protein sorting-associated protein 26B-like [Zootermopsis nevadensis] 545849340 XM_003482653.2 172 1.94305e-82 PREDICTED: Sus scrofa vacuolar protein sorting-associated protein 26B-like (LOC100738900), mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q9W552 1291 9.5e-141 Vacuolar protein sorting-associated protein 26 OS=Drosophila melanogaster GN=Vps26 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.46749 BF_2 91.88 2.06 2154 645020637 XP_008207240.1 197 2.0e-12 PREDICTED: uncharacterized protein LOC103316246 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46750 BF_2 56.28 1.66 1703 189235363 XP_001808147.1 741 1.3e-75 PREDICTED: uncharacterized protein LOC100142009 [Tribolium castaneum]>gi|270003618|gb|EFA00066.1| hypothetical protein TcasGA2_TC002880 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46751 BF_2 96.72 1.95 2367 91089063 XP_970679.1 2031 4.8e-225 PREDICTED: N-sulphoglucosamine sulphohydrolase isoform X1 [Tribolium castaneum]>gi|270012406|gb|EFA08854.1| hypothetical protein TcasGA2_TC006555 [Tribolium castaneum] 584037463 XM_006753050.1 45 1.03176e-11 PREDICTED: Myotis davidii N-sulfoglucosamine sulfohydrolase (SGSH), partial mRNA K01565 SGSH N-sulfoglucosamine sulfohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01565 P51688 1498 1.3e-164 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens GN=SGSH PE=1 SV=1 PF09004//PF00884//PF07931//PF01663//PF02076//PF00010 Domain of unknown function (DUF1891)//Sulfatase//Chloramphenicol phosphotransferase-like protein//Type I phosphodiesterase / nucleotide pyrophosphatase//Pheromone A receptor//Helix-loop-helix DNA-binding domain GO:0007186//GO:0007606//GO:0019236//GO:0055114//GO:0008152 G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//response to pheromone//oxidation-reduction process//metabolic process GO:0008168//GO:0008484//GO:0016706//GO:0004932//GO:0016740//GO:0005524//GO:0003824//GO:0046983 methyltransferase activity//sulfuric ester hydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//mating-type factor pheromone receptor activity//transferase activity//ATP binding//catalytic activity//protein dimerization activity GO:0016021 integral component of membrane KOG3867 Sulfatase Cluster-8309.46752 BF_2 168.20 1.36 5472 270016078 EFA12526.1 1426 1.6e-154 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] 118441617 CR925768.9 53 8.5865e-16 Zebrafish DNA sequence from clone DKEY-20L4 in linkage group 12, complete sequence -- -- -- -- P0CT34 848 6.8e-89 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF02793//PF00665 Hormone receptor domain//Integrase core domain GO:0015074//GO:0007186 DNA integration//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.46753 BF_2 516.00 68.99 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46754 BF_2 478.09 8.69 2589 91091956 XP_968337.1 3381 0.0e+00 PREDICTED: exocyst complex component 6 [Tribolium castaneum]>gi|270000776|gb|EEZ97223.1| hypothetical protein TcasGA2_TC011021 [Tribolium castaneum] 571522972 XM_393572.5 71 3.97877e-26 PREDICTED: Apis mellifera exocyst complex component 6 (sec15), transcript variant 2, mRNA -- -- -- -- Q9VDE6 1952 3.1e-217 Exocyst complex component 6 OS=Drosophila melanogaster GN=sec15 PE=1 SV=1 PF04048//PF04091//PF01207 Sec8 exocyst complex component specific domain//Exocyst complex subunit Sec15-like//Dihydrouridine synthase (Dus) GO:0006904//GO:0055114//GO:0015031//GO:0008033 vesicle docking involved in exocytosis//oxidation-reduction process//protein transport//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity GO:0000145 exocyst KOG2176 Exocyst complex, subunit SEC15 Cluster-8309.46756 BF_2 287.80 7.28 1941 478252064 ENN72495.1 1626 3.6e-178 hypothetical protein YQE_10836, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWN5 1225 4.7e-133 Protein FAM188A homolog OS=Drosophila melanogaster GN=CG7332 PE=1 SV=1 PF13499//PF13405//PF00036 EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG2871 Uncharacterized conserved protein Cluster-8309.46761 BF_2 127.03 1.16 4870 242018392 XP_002429661.1 498 5.7e-47 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5MCW4 383 5.0e-35 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF05279//PF13465//PF00096 Aspartyl beta-hydroxylase N-terminal region//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.46762 BF_2 65.14 0.79 3746 91089279 XP_970539.1 1682 2.2e-184 PREDICTED: serine/threonine-protein kinase unc-51 isoform X1 [Tribolium castaneum]>gi|270011454|gb|EFA07902.1| hypothetical protein TcasGA2_TC005477 [Tribolium castaneum] 820865549 XM_003698790.2 61 2.09284e-20 PREDICTED: Apis florea serine/threonine-protein kinase unc-51 (LOC100864929), transcript variant X1, mRNA K08269 ULK1_2_3, ATG1 serine/threonine-protein kinase ULK/ATG1 http://www.genome.jp/dbget-bin/www_bget?ko:K08269 Q8IYT8 967 7.4e-103 Serine/threonine-protein kinase ULK2 OS=Homo sapiens GN=ULK2 PE=1 SV=3 PF06293//PF00069//PF07714//PF12063 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Domain of unknown function (DUF3543) GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674//GO:0000166//GO:0016773 ATP binding//protein kinase activity//protein serine/threonine kinase activity//nucleotide binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0595 Serine/threonine-protein kinase involved in autophagy Cluster-8309.46765 BF_2 118.27 1.76 3102 91088055 XP_967186.1 1467 1.6e-159 PREDICTED: inositol-3-phosphate synthase [Tribolium castaneum]>gi|270012832|gb|EFA09280.1| inositol-3-phosphate synthase [Tribolium castaneum] 194754672 XM_001959583.1 111 2.77387e-48 Drosophila ananassae GF11950 (Dana\GF11950), mRNA K01858 INO1, ISYNA1 myo-inositol-1-phosphate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01858 Q2NL29 1243 6.1e-135 Inositol-3-phosphate synthase 1 OS=Bos taurus GN=ISYNA1 PE=2 SV=1 PF13762//PF07994//PF13912 Mitochondrial splicing apparatus component//Myo-inositol-1-phosphate synthase//C2H2-type zinc finger GO:0006021//GO:0000372//GO:0019872//GO:0008654 inositol biosynthetic process//Group I intron splicing//streptomycin biosynthetic process//phospholipid biosynthetic process GO:0004512//GO:0046872//GO:0000166 inositol-3-phosphate synthase activity//metal ion binding//nucleotide binding GO:0030529 intracellular ribonucleoprotein complex KOG0693 Myo-inositol-1-phosphate synthase Cluster-8309.46766 BF_2 47.25 0.42 4997 642928750 XP_008199767.1 3233 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 659 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- Q9UPX0 212 3.5e-15 Protein turtle homolog B OS=Homo sapiens GN=IGSF9B PE=2 SV=2 PF00001//PF13895 7 transmembrane receptor (rhodopsin family)//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.46767 BF_2 23.48 0.38 2856 642928750 XP_008199767.1 2932 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 658 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- O60500 211 2.6e-15 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF00001//PF13895 7 transmembrane receptor (rhodopsin family)//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.46768 BF_2 543.43 8.64 2917 642915551 XP_008190663.1 1295 1.3e-139 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 71 4.48679e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 2.3e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076//PF01480 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PWI domain GO:0006397 mRNA processing GO:0003676 nucleic acid binding -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.46769 BF_2 10.59 0.37 1475 642915224 XP_008190530.1 1919 2.9e-212 PREDICTED: TGF-beta receptor type-1 isoform X2 [Tribolium castaneum] 589944031 XM_006984651.1 98 2.19621e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 P80204 1438 7.1e-158 TGF-beta receptor type-1 OS=Rattus norvegicus GN=Tgfbr1 PE=1 SV=1 PF08515//PF00069//PF01064//PF07714 Transforming growth factor beta type I GS-motif//Protein kinase domain//Activin types I and II receptor domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310//GO:0007178 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004672//GO:0004675//GO:0005524 protein kinase activity//transmembrane receptor protein serine/threonine kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.46770 BF_2 7.00 0.33 1182 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46773 BF_2 124.81 1.39 4032 546684171 ERL93876.1 1173 2.5e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P57775 470 3.4e-45 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF00646//PF01442//PF00400//PF15966//PF03357//PF12937 F-box domain//Apolipoprotein A1/A4/E domain//WD domain, G-beta repeat//F-box//Snf7//F-box-like GO:0042157//GO:0007034//GO:0006869 lipoprotein metabolic process//vacuolar transport//lipid transport GO:0008289//GO:0005515 lipid binding//protein binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.46775 BF_2 35.48 0.54 3041 91084211 XP_968214.1 750 2.1e-76 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 282 1.6e-23 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.46776 BF_2 2593.94 12.79 8768 189238003 XP_969912.2 3006 0.0e+00 PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925068|ref|XP_008194156.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|642925070|ref|XP_008194157.1| PREDICTED: uncharacterized protein LOC658431 isoform X1 [Tribolium castaneum]>gi|270008050|gb|EFA04498.1| hypothetical protein TcasGA2_TC014806 [Tribolium castaneum] 642925074 XM_008195937.1 248 5.48987e-124 PREDICTED: Tribolium castaneum suppressor of presenilin protein 4 (LOC658431), transcript variant X5, mRNA -- -- -- -- Q96IR2 252 1.4e-19 Zinc finger protein 845 OS=Homo sapiens GN=ZNF845 PE=2 SV=3 PF04988//PF00096//PF13465//PF02196//PF05792//PF00715 A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain//Raf-like Ras-binding domain//Candida agglutinin-like (ALS)//Interleukin 2 GO:0008283//GO:0007165//GO:0040007//GO:0007155//GO:0006955 cell proliferation//signal transduction//growth//cell adhesion//immune response GO:0005057//GO:0003677//GO:0008083//GO:0046872//GO:0005134 receptor signaling protein activity//DNA binding//growth factor activity//metal ion binding//interleukin-2 receptor binding GO:0005634//GO:0005893//GO:0005576 nucleus//interleukin-2 receptor complex//extracellular region -- -- Cluster-8309.46777 BF_2 46.43 0.43 4818 751224154 XP_011165403.1 320 2.5e-26 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08103 Uperin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.46778 BF_2 1009.09 32.70 1578 189239803 XP_970743.2 1004 3.9e-106 PREDICTED: TRAF-type zinc finger domain-containing protein 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R970 128 6.1e-06 TRAF-type zinc finger domain-containing protein 1 OS=Macaca fascicularis GN=TRAFD1 PE=2 SV=1 PF01258 Prokaryotic dksA/traR C4-type zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.46779 BF_2 90.56 3.96 1243 642919467 XP_008191881.1 497 1.9e-47 PREDICTED: polyprenol reductase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLP9 326 5.2e-29 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1640 Predicted steroid reductase Cluster-8309.46781 BF_2 1842.73 8.86 8989 642937658 XP_008198888.1 6936 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 14 [Tribolium castaneum] 157132702 XM_001662569.1 146 2.83078e-67 Aedes aegypti AAEL012490-RA partial mRNA K15156 MED14, RGR1 mediator of RNA polymerase II transcription subunit 14 http://www.genome.jp/dbget-bin/www_bget?ko:K15156 Q16U49 4416 0.0e+00 Mediator of RNA polymerase II transcription subunit 14 OS=Aedes aegypti GN=MED14 PE=3 SV=2 PF08638 Mediator complex subunit MED14 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG1875 Thyroid hormone receptor-associated coactivator complex component (TRAP170) Cluster-8309.46783 BF_2 11.88 0.58 1137 546680604 ERL90847.1 242 6.4e-18 hypothetical protein D910_08192 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46784 BF_2 491.00 67.81 590 642926014 XP_008194728.1 467 2.7e-44 PREDICTED: ATP-citrate synthase isoform X1 [Tribolium castaneum]>gi|642926016|ref|XP_008194729.1| PREDICTED: ATP-citrate synthase isoform X1 [Tribolium castaneum] 50540365 NM_001002649.1 42 1.14486e-10 Danio rerio ATP citrate lyase a (aclya), mRNA >gnl|BL_ORD_ID|2650124 Danio rerio ATP citrate lyase, mRNA (cDNA clone MGC:92008 IMAGE:7043656), complete cds K01648 ACLY ATP citrate (pro-S)-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01648 Q32PF2 295 9.8e-26 ATP-citrate synthase OS=Bos taurus GN=ACLY PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1254 ATP-citrate lyase Cluster-8309.46785 BF_2 18.39 2.47 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46789 BF_2 741.81 8.94 3759 91077592 XP_973319.1 1821 1.7e-200 PREDICTED: decaprenyl-diphosphate synthase subunit 1 [Tribolium castaneum] 645030079 XM_008211983.1 197 5.25135e-96 PREDICTED: Nasonia vitripennis decaprenyl-diphosphate synthase subunit 1 (LOC100118369), transcript variant X4, mRNA K12504 PDSS1 decaprenyl-diphosphate synthase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12504 Q5T2R2 916 6.1e-97 Decaprenyl-diphosphate synthase subunit 1 OS=Homo sapiens GN=PDSS1 PE=1 SV=1 PF01783//PF00348 Ribosomal L32p protein family//Polyprenyl synthetase GO:0042254//GO:0008299//GO:0006412 ribosome biogenesis//isoprenoid biosynthetic process//translation GO:0003735 structural constituent of ribosome GO:0015934//GO:0005840 large ribosomal subunit//ribosome KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.46790 BF_2 122.15 0.80 6705 546675629 ERL86779.1 7291 0.0e+00 hypothetical protein D910_04185 [Dendroctonus ponderosae] 705688754 XM_010123154.1 36 2.96923e-06 PREDICTED: Chlamydotis macqueenii activating signal cointegrator 1 complex subunit 3 (ASCC3), partial mRNA K18663 ASCC3 activating signal cointegrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18663 F1NTD6 3909 0.0e+00 Activating signal cointegrator 1 complex subunit 3 OS=Gallus gallus GN=ascc3 PE=3 SV=2 PF00437//PF00270//PF02562//PF00098//PF04851//PF00176//PF00580 Type II/IV secretion system protein//DEAD/DEAH box helicase//PhoH-like protein//Zinc knuckle//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//UvrD/REP helicase N-terminal domain GO:0006810 transport GO:0003676//GO:0016787//GO:0003677//GO:0008270//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//zinc ion binding//ATP binding -- -- KOG0952 DNA/RNA helicase MER3/SLH1, DEAD-box superfamily Cluster-8309.46793 BF_2 1468.20 21.54 3138 642917797 XP_008191290.1 2396 3.0e-267 PREDICTED: NAD-dependent histone deacetylase Sir2 [Tribolium castaneum]>gi|270003357|gb|EEZ99804.1| hypothetical protein TcasGA2_TC002584 [Tribolium castaneum] -- -- -- -- -- K11411 SIRT1, SIR2L1 NAD-dependent deacetylase sirtuin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11411 Q9VK34 1115 4.3e-120 NAD-dependent histone deacetylase Sir2 OS=Drosophila melanogaster GN=Sir2 PE=1 SV=1 PF04574//PF00205//PF02146 Protein of unknown function (DUF592)//Thiamine pyrophosphate enzyme, central domain//Sir2 family GO:0006355//GO:0006807//GO:0006476//GO:0006342 regulation of transcription, DNA-templated//nitrogen compound metabolic process//protein deacetylation//chromatin silencing GO:0008270//GO:0030976//GO:0000287//GO:0016811//GO:0017136//GO:0070403//GO:0051287 zinc ion binding//thiamine pyrophosphate binding//magnesium ion binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//NAD-dependent histone deacetylase activity//NAD+ binding//NAD binding GO:0000118 histone deacetylase complex KOG2684 Sirtuin 5 and related class III sirtuins (SIR2 family) Cluster-8309.46794 BF_2 1130.60 9.76 5133 270013169 EFA09617.1 2364 2.5e-263 hypothetical protein TcasGA2_TC011738 [Tribolium castaneum] 195495540 XM_002095275.1 180 2.02741e-86 Drosophila yakuba GE19764 (Dyak\GE19764), partial mRNA K08819 CDK12_13 cyclin-dependent kinase 12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K08819 Q9VP22 1822 7.3e-202 Cyclin-dependent kinase 12 OS=Drosophila melanogaster GN=Cdk12 PE=1 SV=1 PF08272//PF00069//PF03092//PF00876//PF04505//PF07714 Topoisomerase I zinc-ribbon-like//Protein kinase domain//BT1 family//Innexin//Interferon-induced transmembrane protein//Protein tyrosine kinase GO:0006468//GO:0006810//GO:0006265//GO:0009607 protein phosphorylation//transport//DNA topological change//response to biotic stimulus GO:0005524//GO:0003677//GO:0004672//GO:0003918 ATP binding//DNA binding//protein kinase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0016021//GO:0005921//GO:0005694 integral component of membrane//gap junction//chromosome KOG0600 Cdc2-related protein kinase Cluster-8309.46796 BF_2 281.37 3.55 3605 642927427 XP_008195268.1 1097 1.5e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF00096 zinc-finger C2H2-type//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.46797 BF_2 31.73 0.42 3433 91080655 XP_974603.1 512 9.5e-49 PREDICTED: post-GPI attachment to proteins factor 2 [Tribolium castaneum]>gi|270005499|gb|EFA01947.1| hypothetical protein TcasGA2_TC007562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UHJ9 296 4.4e-25 Post-GPI attachment to proteins factor 2 OS=Homo sapiens GN=PGAP2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.46799 BF_2 124.83 0.82 6642 642930492 XP_008196426.1 2252 3.2e-250 PREDICTED: CLIP-associating protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 5.2e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF02985//PF03153//PF12844//PF01528 HEAT repeat//Transcription factor IIA, alpha/beta subunit//Helix-turn-helix domain//Herpesvirus glycoprotein M GO:0006367 transcription initiation from RNA polymerase II promoter GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding GO:0005672//GO:0016020 transcription factor TFIIA complex//membrane -- -- Cluster-8309.46800 BF_2 187.00 3.72 2388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46802 BF_2 117.62 2.10 2630 642932900 XP_008197178.1 2035 1.8e-225 PREDICTED: carboxypeptidase M isoform X1 [Tribolium castaneum] 170072561 XM_001870172.1 158 1.7524e-74 Culex quinquefasciatus carboxypeptidase D, mRNA K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q5RFD6 991 8.6e-106 Carboxypeptidase M OS=Pongo abelii GN=CPM PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008270//GO:0016788//GO:0004181 zinc ion binding//hydrolase activity, acting on ester bonds//metallocarboxypeptidase activity -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.46804 BF_2 185.34 3.11 2778 642932902 XP_008197179.1 1991 2.4e-220 PREDICTED: carboxypeptidase M isoform X2 [Tribolium castaneum] 170072561 XM_001870172.1 158 1.85108e-74 Culex quinquefasciatus carboxypeptidase D, mRNA K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 Q80V42 993 5.3e-106 Carboxypeptidase M OS=Mus musculus GN=Cpm PE=2 SV=2 PF00246//PF04952 Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004181//GO:0008270//GO:0016788 metallocarboxypeptidase activity//zinc ion binding//hydrolase activity, acting on ester bonds -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.46809 BF_2 5.00 21.14 258 546678141 ERL88850.1 161 3.6e-09 hypothetical protein D910_06232 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46810 BF_2 84.00 4.25 1113 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46811 BF_2 38.55 2.56 917 642934441 XP_008197664.1 1106 3.4e-118 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X3 [Tribolium castaneum] 242013552 XM_002427424.1 112 2.22255e-49 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K11728 BPTF, E(bx) nucleosome-remodeling factor subunit BPTF http://www.genome.jp/dbget-bin/www_bget?ko:K11728 Q9W0T1 699 2.2e-72 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00628//PF16866//PF00108//PF13639 PHD-finger//PHD-finger//Thiolase, N-terminal domain//Ring finger domain GO:0008152 metabolic process GO:0008270//GO:0005515//GO:0016747 zinc ion binding//protein binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.46812 BF_2 5.44 1.67 423 514683686 XP_004989424.1 217 1.9e-15 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- O54963 170 2.2e-11 RE1-silencing transcription factor OS=Rattus norvegicus GN=Rest PE=2 SV=1 PF04988//PF00096//PF13465//PF02150 A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.46814 BF_2 15.00 0.81 1065 642923174 XP_008193640.1 404 9.9e-37 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V877 246 8.5e-20 Kinesin-like protein subito OS=Drosophila melanogaster GN=sub PE=1 SV=1 PF00225//PF01146 Kinesin motor domain//Caveolin GO:0007018//GO:0007017//GO:0070836 microtubule-based movement//microtubule-based process//caveola assembly GO:0003777//GO:0005524//GO:0008017 microtubule motor activity//ATP binding//microtubule binding GO:0045298//GO:0005874 tubulin complex//microtubule KOG0242 Kinesin-like protein Cluster-8309.46817 BF_2 38.67 0.70 2598 642915296 XP_008190559.1 391 7.7e-35 PREDICTED: signal recognition particle 9 kDa protein [Tribolium castaneum]>gi|270004979|gb|EFA01427.1| hypothetical protein TcasGA2_TC030568 [Tribolium castaneum] -- -- -- -- -- K03109 SRP9 signal recognition particle subunit SRP9 http://www.genome.jp/dbget-bin/www_bget?ko:K03109 Q9VSC1 231 1.1e-17 Signal recognition particle 9 kDa protein OS=Drosophila melanogaster GN=Srp9 PE=3 SV=1 -- -- GO:0045900//GO:0006614 negative regulation of translational elongation//SRP-dependent cotranslational protein targeting to membrane GO:0008312 7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3465 Signal recognition particle, subunit Srp9 Cluster-8309.46819 BF_2 49.56 0.50 4459 91079768 XP_966889.1 792 4.2e-81 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 385 2.7e-35 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF01073//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0055114//GO:0006694//GO:0008209//GO:0008207 metabolic process//estrogen metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.46824 BF_2 107.80 0.80 5895 642937978 XP_008199153.1 4516 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 76 1.51611e-28 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 2441 1.4e-273 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF00005//PF03193//PF04310//PF06414//PF13304//PF00352//PF00448 ABC transporter//Protein of unknown function, DUF258//MukB N-terminal//Zeta toxin//AAA domain, putative AbiEii toxin, Type IV TA system//Transcription factor TFIID (or TATA-binding protein, TBP)//SRP54-type protein, GTPase domain GO:0006352//GO:0007059//GO:0030261//GO:0006614 DNA-templated transcription, initiation//chromosome segregation//chromosome condensation//SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0016887//GO:0016301//GO:0005524//GO:0003677//GO:0003924 GTP binding//ATPase activity//kinase activity//ATP binding//DNA binding//GTPase activity GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.46825 BF_2 8.21 0.45 1055 646722316 KDR23329.1 269 4.4e-21 DNA repair protein RAD51-like protein 3 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8GXF0 214 4.3e-16 DNA repair protein RAD51 homolog 3 OS=Arabidopsis thaliana GN=RAD51C PE=1 SV=2 PF16836 Shu complex component Psy3, DNA-binding description GO:0000725 recombinational repair -- -- GO:0005634//GO:0097196 nucleus//Shu complex KOG1433 DNA repair protein RAD51/RHP55 Cluster-8309.46826 BF_2 219.68 1.20 7969 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 201 6.684e-98 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF00097//PF17122//PF14634//PF02148//PF02723//PF12678//PF00569//PF00443//PF12861//PF01165//PF00637//PF13639//PF05680 Zinc finger, C3HC4 type (RING finger)//Zinc-finger//zinc-RING finger domain//Zn-finger in ubiquitin-hydrolases and other protein//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Zinc finger, ZZ type//Ubiquitin carboxyl-terminal hydrolase//Anaphase-promoting complex subunit 11 RING-H2 finger//Ribosomal protein S21//Region in Clathrin and VPS//Ring finger domain//ATP synthase E chain GO:0016192//GO:0006886//GO:0015992//GO:0042254//GO:0016579//GO:0016567//GO:0006412//GO:0015986 vesicle-mediated transport//intracellular protein transport//proton transport//ribosome biogenesis//protein deubiquitination//protein ubiquitination//translation//ATP synthesis coupled proton transport GO:0036459//GO:0008270//GO:0003735//GO:0015078//GO:0004842//GO:0005515//GO:0046872 ubiquitinyl hydrolase activity//zinc ion binding//structural constituent of ribosome//hydrogen ion transmembrane transporter activity//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005840//GO:0005680//GO:0000276//GO:0016020 ribosome//anaphase-promoting complex//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//membrane KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.46827 BF_2 891.15 12.58 3251 478263518 ENN81868.1 2723 3.8e-305 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68EI3 1268 8.1e-138 Cytosolic carboxypeptidase-like protein 5 OS=Danio rerio GN=agbl5 PE=2 SV=1 PF04828//PF00246//PF07776//PF04952//PF05656 Glutathione-dependent formaldehyde-activating enzyme//Zinc carboxypeptidase//Zinc-finger associated domain (zf-AD)//Succinylglutamate desuccinylase / Aspartoacylase family//Protein of unknown function (DUF805) GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016788//GO:0008270//GO:0016846//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//carbon-sulfur lyase activity//metallocarboxypeptidase activity GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3641 Zinc carboxypeptidase Cluster-8309.46828 BF_2 122.15 1.23 4425 478263518 ENN81868.1 2311 3.0e-257 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68EI3 1268 1.1e-137 Cytosolic carboxypeptidase-like protein 5 OS=Danio rerio GN=agbl5 PE=2 SV=1 PF04828//PF00246//PF07776//PF05656//PF04952 Glutathione-dependent formaldehyde-activating enzyme//Zinc carboxypeptidase//Zinc-finger associated domain (zf-AD)//Protein of unknown function (DUF805)//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0004181//GO:0016846//GO:0008270//GO:0016788 metallocarboxypeptidase activity//carbon-sulfur lyase activity//zinc ion binding//hydrolase activity, acting on ester bonds GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3641 Zinc carboxypeptidase Cluster-8309.46829 BF_2 38.81 1.00 1910 270011957 EFA08405.1 805 5.6e-83 hypothetical protein TcasGA2_TC006052 [Tribolium castaneum] -- -- -- -- -- K04710 CERS ceramide synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K04710 Q8C172 470 1.6e-45 Ceramide synthase 6 OS=Mus musculus GN=Cers6 PE=1 SV=1 PF03798//PF12766 TLC domain//Pyridoxamine 5'-phosphate oxidase -- -- GO:0010181 FMN binding GO:0016021 integral component of membrane KOG1607 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.46830 BF_2 823.30 92.37 660 642913091 XP_008201388.1 456 5.7e-43 PREDICTED: disks large 1 tumor suppressor protein isoform X10 [Tribolium castaneum] 642913090 XM_008203166.1 194 4.1107e-95 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X11, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 309 2.6e-27 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.46831 BF_2 9.00 0.32 1472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46833 BF_2 358.46 2.63 5980 642911486 XP_008199444.1 557 1.0e-53 PREDICTED: Na(+)/H(+) exchange regulatory cofactor NHE-RF2 [Tribolium castaneum]>gi|270014790|gb|EFA11238.1| hypothetical protein TcasGA2_TC010770 [Tribolium castaneum] -- -- -- -- -- K13358 SLC9A3R2, NHERF2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 http://www.genome.jp/dbget-bin/www_bget?ko:K13358 Q5ZM14 257 2.5e-20 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Gallus gallus GN=SLC9A3R1 PE=2 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.46834 BF_2 58.64 0.84 3197 642929628 XP_008195910.1 593 3.6e-58 PREDICTED: integrin alpha-X-like [Tribolium castaneum] -- -- -- -- -- K06585 ITGA9 integrin alpha 9 http://www.genome.jp/dbget-bin/www_bget?ko:K06585 P13612 380 7.4e-35 Integrin alpha-4 OS=Homo sapiens GN=ITGA4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46836 BF_2 255.43 10.86 1271 91087219 XP_975481.1 675 4.4e-68 PREDICTED: pinin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H307 323 1.2e-28 Pinin OS=Homo sapiens GN=PNN PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46838 BF_2 580.80 3.82 6643 270006862 EFA03310.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q96IG2 1483 1.9e-162 F-box/LRR-repeat protein 20 OS=Homo sapiens GN=FBXL20 PE=1 SV=2 PF13516//PF12937//PF02126//PF00560//PF00646//PF15966//PF13855//PF00152 Leucine Rich repeat//F-box-like//Phosphotriesterase family//Leucine Rich Repeat//F-box domain//F-box//Leucine rich repeat//tRNA synthetases class II (D, K and N) GO:0009056//GO:0006418 catabolic process//tRNA aminoacylation for protein translation GO:0004812//GO:0005515//GO:0000166//GO:0005524//GO:0008270 aminoacyl-tRNA ligase activity//protein binding//nucleotide binding//ATP binding//zinc ion binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.46844 BF_2 19.29 1.08 1033 91078348 XP_973652.1 149 3.5e-07 PREDICTED: prostaglandin E synthase 2 [Tribolium castaneum]>gi|270003893|gb|EFA00341.1| hypothetical protein TcasGA2_TC003180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0045454//GO:0006118 cell redox homeostasis//obsolete electron transport GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- -- -- Cluster-8309.46846 BF_2 90.64 1.56 2719 642935358 XP_008197980.1 1191 1.4e-127 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46848 BF_2 457.77 10.77 2066 91086285 XP_967226.1 1600 4.0e-175 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] 827562488 XM_012696459.1 44 3.23188e-11 PREDICTED: Bombyx mori 4-coumarate--CoA ligase 1-like (LOC101735849), mRNA -- -- -- -- Q27757 1167 2.6e-126 Luciferin 4-monooxygenase OS=Photuris pennsylvanica PE=2 SV=2 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.46854 BF_2 164.01 1.54 4747 646710672 KDR16118.1 400 1.3e-35 hypothetical protein L798_10008 [Zootermopsis nevadensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 383 4.9e-35 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF13465//PF13912//PF16622//PF01113//PF00096//PF03015//PF00044//PF08533//PF07776 Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type//Dihydrodipicolinate reductase, N-terminus//Zinc finger, C2H2 type//Male sterility protein//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Beta-galactosidase C-terminal domain//Zinc-finger associated domain (zf-AD) GO:0046486//GO:0006687//GO:0055114//GO:0006027//GO:0009085//GO:0006012//GO:0009089 glycerolipid metabolic process//glycosphingolipid metabolic process//oxidation-reduction process//glycosaminoglycan catabolic process//lysine biosynthetic process//galactose metabolic process//lysine biosynthetic process via diaminopimelate GO:0016620//GO:0046872//GO:0080019//GO:0008270//GO:0004565//GO:0008839 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//metal ion binding//fatty-acyl-CoA reductase (alcohol-forming) activity//zinc ion binding//beta-galactosidase activity//4-hydroxy-tetrahydrodipicolinate reductase GO:0009341//GO:0005634 beta-galactosidase complex//nucleus -- -- Cluster-8309.46856 BF_2 792.76 6.63 5286 642928433 XP_008193783.1 6152 0.0e+00 PREDICTED: proteasome activator complex subunit 4 [Tribolium castaneum]>gi|270010813|gb|EFA07261.1| hypothetical protein TcasGA2_TC013292 [Tribolium castaneum] -- -- -- -- -- K06699 PSME4 proteasome activator subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K06699 Q6NRP2 2946 0.0e+00 Proteasome activator complex subunit 4 OS=Xenopus laevis GN=psme4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1851 Uncharacterized conserved protein Cluster-8309.46857 BF_2 1033.89 11.01 4216 546683122 ERL92973.1 2083 7.9e-231 hypothetical protein D910_10276 [Dendroctonus ponderosae] 237874246 NM_001160401.1 165 3.62457e-78 Acyrthosiphon pisum aspartyl-tRNA synthetase (Aats-asp), mRNA K01876 DARS, aspS aspartyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01876 P14868 1669 3.3e-184 Aspartate--tRNA ligase, cytoplasmic OS=Homo sapiens GN=DARS PE=1 SV=2 PF00152//PF11538//PF01409 tRNA synthetases class II (D, K and N)//Snurportin1//tRNA synthetases class II core domain (F) GO:0006418//GO:0043039 tRNA aminoacylation for protein translation//tRNA aminoacylation GO:0000166//GO:0004812//GO:0005524//GO:0000049//GO:0005515 nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//tRNA binding//protein binding GO:0005737 cytoplasm KOG0556 Aspartyl-tRNA synthetase Cluster-8309.46858 BF_2 45.97 0.44 4704 642922794 XP_008193328.1 680 4.3e-68 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 403 2.3e-37 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46862 BF_2 316.52 2.14 6479 642914773 XP_008190345.1 1450 3.1e-157 PREDICTED: protein SERAC1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SNQ7 389 1.4e-35 Protein SERAC1 OS=Danio rerio GN=serac1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46865 BF_2 533.00 12.84 2024 91081605 XP_975406.1 2055 6.7e-228 PREDICTED: conserved oligomeric Golgi complex subunit 8 [Tribolium castaneum]>gi|270006211|gb|EFA02659.1| hypothetical protein TcasGA2_TC008380 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKH0 1330 3.2e-145 Conserved oligomeric Golgi complex subunit 8 OS=Drosophila melanogaster GN=CG6488 PE=2 SV=1 PF04124//PF06248 Dor1-like family//Centromere/kinetochore Zw10 GO:0007067 mitotic nuclear division -- -- GO:0017119//GO:0000775//GO:0005634 Golgi transport complex//chromosome, centromeric region//nucleus KOG2069 Golgi transport complex subunit Cluster-8309.46866 BF_2 986.03 8.07 5401 91086067 XP_974022.1 2937 0.0e+00 PREDICTED: snake venom 5'-nucleotidase isoform X1 [Tribolium castaneum]>gi|270009911|gb|EFA06359.1| hypothetical protein TcasGA2_TC009234 [Tribolium castaneum] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 O34313 387 1.9e-35 Trifunctional nucleotide phosphoesterase protein YfkN OS=Bacillus subtilis (strain 168) GN=yfkN PE=1 SV=1 PF02872//PF00149 5'-nucleotidase, C-terminal domain//Calcineurin-like phosphoesterase GO:0009166 nucleotide catabolic process GO:0016787 hydrolase activity -- -- KOG4697 Integral membrane protein involved in transport between the late Golgi and endosome Cluster-8309.46868 BF_2 21.00 0.50 2055 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46869 BF_2 3.00 1.13 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46871 BF_2 442.00 4.78 4153 765150019 XP_011485511.1 184 1.2e-10 PREDICTED: ring-infected erythrocyte surface antigen-like [Oryzias latipes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04947 Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.46872 BF_2 281.71 1.41 8627 546674242 ERL85667.1 1272 1.8e-136 hypothetical protein D910_03084 [Dendroctonus ponderosae] -- -- -- -- -- K15698 RNF121 RING finger protein 121 http://www.genome.jp/dbget-bin/www_bget?ko:K15698 Q9VHN9 460 1.1e-43 Hermansky-Pudlak syndrome 5 protein homolog OS=Drosophila melanogaster GN=p PE=2 SV=1 PF13639//PF12678 Ring finger domain//RING-H2 zinc finger -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1734 Predicted RING-containing E3 ubiquitin ligase Cluster-8309.46875 BF_2 33.01 0.81 1992 478251087 ENN71563.1 634 3.9e-63 hypothetical protein YQE_11664, partial [Dendroctonus ponderosae] -- -- -- -- -- K05687 PARK7 protein DJ-1 http://www.genome.jp/dbget-bin/www_bget?ko:K05687 Q5XJ36 436 1.5e-41 Protein deglycase DJ-1zDJ-1 OS=Danio rerio GN=park7 PE=2 SV=1 PF07685//PF08465 CobB/CobQ-like glutamine amidotransferase domain//Thymidine kinase from Herpesvirus C-terminal GO:0009236//GO:0006206//GO:0006230 cobalamin biosynthetic process//pyrimidine nucleobase metabolic process//TMP biosynthetic process GO:0003824//GO:0005524//GO:0004797 catalytic activity//ATP binding//thymidine kinase activity -- -- KOG2764 Putative transcriptional regulator DJ-1 Cluster-8309.46876 BF_2 250.00 6.24 1963 332373082 AEE61682.1 583 3.2e-57 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q05B54 156 4.3e-09 Transmembrane protein 134 OS=Bos taurus GN=TMEM134 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46878 BF_2 91.85 0.45 8807 478258750 ENN78776.1 2014 1.7e-222 hypothetical protein YQE_04763, partial [Dendroctonus ponderosae] 780682419 XM_011699543.1 39 8.39377e-08 PREDICTED: Wasmannia auropunctata anoctamin-1 (LOC105455869), transcript variant X4, mRNA K19480 ANO5, GDD1, TMEM16E anoctamin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K19480 Q75V66 924 1.7e-97 Anoctamin-5 OS=Homo sapiens GN=ANO5 PE=1 SV=1 PF13939//PF16178//PF01091 Toxin TisB, type I toxin-antitoxin system//Dimerisation domain of Ca+-activated chloride-channel, anoctamin//PTN/MK heparin-binding protein family, C-terminal domain GO:0040007//GO:0007165//GO:0008283//GO:0009432//GO:0022611//GO:0006820 growth//signal transduction//cell proliferation//SOS response//dormancy process//anion transport GO:0008083//GO:0046983//GO:0005253 growth factor activity//protein dimerization activity//anion channel activity GO:0005887 integral component of plasma membrane KOG2514 Uncharacterized conserved protein Cluster-8309.46881 BF_2 37.76 0.95 1957 478259228 ENN79130.1 801 1.7e-82 hypothetical protein YQE_04317, partial [Dendroctonus ponderosae] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 O34940 288 2.1e-24 Putative sugar lactone lactonase YvrE OS=Bacillus subtilis (strain 168) GN=yvrE PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46883 BF_2 2.00 7.71 261 123423385 XP_001306365.1 175 8.6e-11 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121887935|gb|EAX93435.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 151 2.1e-09 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46884 BF_2 253.98 2.84 4030 546684171 ERL93876.1 1173 2.5e-125 hypothetical protein D910_11162 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P57775 470 3.4e-45 F-box/WD repeat-containing protein 4 OS=Homo sapiens GN=FBXW4 PE=2 SV=1 PF15966//PF00400//PF00646//PF01442//PF12937//PF03357 F-box//WD domain, G-beta repeat//F-box domain//Apolipoprotein A1/A4/E domain//F-box-like//Snf7 GO:0007034//GO:0006869//GO:0042157 vacuolar transport//lipid transport//lipoprotein metabolic process GO:0005515//GO:0008289 protein binding//lipid binding GO:0005576 extracellular region KOG2911 Uncharacterized conserved protein Cluster-8309.46885 BF_2 9.95 0.31 1616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02388 FemAB family GO:0009252 peptidoglycan biosynthetic process GO:0016755 transferase activity, transferring amino-acyl groups -- -- -- -- Cluster-8309.46886 BF_2 114.00 3.18 1787 817088843 XP_012267256.1 438 1.9e-40 PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae]>gi|817088845|ref|XP_012267257.1| PREDICTED: DNA-directed RNA polymerase I subunit RPA43 [Athalia rosae] -- -- -- -- -- K03004 RPA43 DNA-directed RNA polymerase I subunit RPA43 http://www.genome.jp/dbget-bin/www_bget?ko:K03004 Q3B726 275 6.2e-23 DNA-directed RNA polymerase I subunit RPA43 OS=Homo sapiens GN=TWISTNB PE=1 SV=1 PF03876 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003899 DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG4134 DNA-dependent RNA polymerase I Cluster-8309.46887 BF_2 151.02 2.30 3033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46888 BF_2 949.85 11.44 3761 642926192 XP_008194823.1 1297 9.8e-140 PREDICTED: glycylpeptide N-tetradecanoyltransferase 2 [Tribolium castaneum] -- -- -- -- -- K00671 E2.3.1.97, NMT glycylpeptide N-tetradecanoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00671 P30419 1044 8.8e-112 Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens GN=NMT1 PE=1 SV=2 PF01233//PF07402//PF13508//PF02799 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain//Human herpesvirus U26 protein//Acetyltransferase (GNAT) domain//Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0004379 N-acetyltransferase activity//glycylpeptide N-tetradecanoyltransferase activity GO:0016021 integral component of membrane KOG2779 N-myristoyl transferase Cluster-8309.46889 BF_2 1245.15 22.19 2635 642926192 XP_008194823.1 1891 9.1e-209 PREDICTED: glycylpeptide N-tetradecanoyltransferase 2 [Tribolium castaneum] 670428483 XM_008656828.1 53 4.10815e-16 PREDICTED: Zea mays glycylpeptide N-tetradecanoyltransferase 1 (LOC100283890), transcript variant X2, mRNA K00671 E2.3.1.97, NMT glycylpeptide N-tetradecanoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00671 P30419 1554 4.5e-171 Glycylpeptide N-tetradecanoyltransferase 1 OS=Homo sapiens GN=NMT1 PE=1 SV=2 PF02799//PF13508//PF07402//PF01233 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain//Acetyltransferase (GNAT) domain//Human herpesvirus U26 protein//Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0004379//GO:0008080 glycylpeptide N-tetradecanoyltransferase activity//N-acetyltransferase activity GO:0016021 integral component of membrane KOG2779 N-myristoyl transferase Cluster-8309.46892 BF_2 98.00 3.75 1380 768443194 XP_011563401.1 213 1.8e-14 PREDICTED: homeobox protein 6-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588 C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.46895 BF_2 74.69 0.96 3545 642922624 XP_008193254.1 3526 0.0e+00 PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum]>gi|642922626|ref|XP_008193255.1| PREDICTED: uncharacterized protein LOC659317 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46896 BF_2 48.13 0.71 3115 91092214 XP_969938.1 2127 4.6e-236 PREDICTED: uncharacterized protein LOC658457 [Tribolium castaneum]>gi|270014434|gb|EFA10882.1| hypothetical protein TcasGA2_TC001706 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P48613 198 9.1e-14 Protein tipE OS=Drosophila melanogaster GN=tipE PE=2 SV=1 PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.46898 BF_2 1196.52 10.56 5027 642927882 XP_008195435.1 2852 0.0e+00 PREDICTED: zinc finger protein 609-like isoform X2 [Tribolium castaneum] 642927883 XM_008197214.1 252 1.87601e-126 PREDICTED: Tribolium castaneum zinc finger protein 608-like (LOC662416), transcript variant X3, mRNA -- -- -- -- Q56A10 383 5.2e-35 Zinc finger protein 608 OS=Mus musculus GN=Znf608 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46899 BF_2 22.75 0.34 3082 315258628 BAG14262.2 320 1.6e-26 44 kDa zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P13582 227 3.9e-17 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.46903 BF_2 401.97 2.95 5988 91080961 XP_974748.1 580 2.2e-56 PREDICTED: ubiquitin-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z2M6 446 3.1e-42 Ubiquitin-like protein 3 OS=Mus musculus GN=Ubl3 PE=1 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46904 BF_2 328.03 2.36 6092 91080961 XP_974748.1 580 2.2e-56 PREDICTED: ubiquitin-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Z2M6 446 3.1e-42 Ubiquitin-like protein 3 OS=Mus musculus GN=Ubl3 PE=1 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.46908 BF_2 451.15 5.27 3867 91087699 XP_974256.1 950 1.7e-99 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 518 8.9e-51 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF01036//PF00852 Bacteriorhodopsin-like protein//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0070085//GO:0006486 glycosylation//protein glycosylation GO:0008417//GO:0016757 fucosyltransferase activity//transferase activity, transferring glycosyl groups GO:0005794//GO:0016020 Golgi apparatus//membrane KOG2619 Fucosyltransferase Cluster-8309.46909 BF_2 773.20 2.98 11144 642910592 XP_008200017.1 3242 0.0e+00 PREDICTED: uncharacterized protein LOC103314818 isoform X2 [Tribolium castaneum] 642910591 XM_008201795.1 107 1.68098e-45 PREDICTED: Tribolium castaneum uncharacterized LOC103314818 (LOC103314818), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07359//PF08272 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2)//Topoisomerase I zinc-ribbon-like GO:0006265//GO:0042742 DNA topological change//defense response to bacterium GO:0003677//GO:0003918 DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005694 chromosome -- -- Cluster-8309.46913 BF_2 116.00 2.01 2698 646705478 KDR13176.1 151 5.4e-07 hypothetical protein L798_12933, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03852//PF05653 DNA mismatch endonuclease Vsr//Magnesium transporter NIPA GO:0006298//GO:0015693 mismatch repair//magnesium ion transport GO:0004519//GO:0015095 endonuclease activity//magnesium ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.46914 BF_2 267.10 4.34 2864 478256087 ENN76286.1 2307 5.7e-257 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 1467 6.0e-161 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF00733//PF00764//PF02568 Asparagine synthase//Arginosuccinate synthase//Thiamine biosynthesis protein (ThiI) GO:0006522//GO:0008033//GO:0006526//GO:0006529//GO:0006531//GO:0006560 alanine metabolic process//tRNA processing//arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process GO:0004066//GO:0004810//GO:0005524//GO:0004055 asparagine synthase (glutamine-hydrolyzing) activity//tRNA adenylyltransferase activity//ATP binding//argininosuccinate synthase activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.46915 BF_2 103.24 2.01 2438 478256087 ENN76286.1 1327 2.1e-143 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 923 6.1e-98 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF00764//PF02568//PF00733 Arginosuccinate synthase//Thiamine biosynthesis protein (ThiI)//Asparagine synthase GO:0006526//GO:0006529//GO:0006531//GO:0006560//GO:0006522//GO:0008033 arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//alanine metabolic process//tRNA processing GO:0004810//GO:0005524//GO:0004055//GO:0004066 tRNA adenylyltransferase activity//ATP binding//argininosuccinate synthase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.46916 BF_2 33.21 0.68 2333 270001539 EEZ97986.1 1123 9.1e-120 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 141 4.37616e-65 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 526 6.3e-52 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF00076//PF16367//PF01174//PF03153 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//SNO glutamine amidotransferase family//Transcription factor IIA, alpha/beta subunit GO:0042819//GO:0006541//GO:0006367//GO:0042823 vitamin B6 biosynthetic process//glutamine metabolic process//transcription initiation from RNA polymerase II promoter//pyridoxal phosphate biosynthetic process GO:0004359//GO:0003676 glutaminase activity//nucleic acid binding GO:0005672 transcription factor TFIIA complex KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.46917 BF_2 2.00 1.46 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46922 BF_2 1163.24 14.96 3540 91087023 XP_974255.1 1314 9.9e-142 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q9C0D9 721 2.4e-74 Ethanolaminephosphotransferase 1 OS=Homo sapiens GN=EPT1 PE=1 SV=3 PF13292 1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694 terpenoid biosynthetic process//steroid biosynthetic process GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity -- -- KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.46923 BF_2 45.00 15.33 409 478250268 ENN70767.1 301 3.3e-25 hypothetical protein YQE_12527, partial [Dendroctonus ponderosae] -- -- -- -- -- K09751 TMPRSS11B transmembrane protease, serine 11B http://www.genome.jp/dbget-bin/www_bget?ko:K09751 P05049 176 4.3e-12 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.46924 BF_2 5.63 0.50 757 242008321 XP_002424955.1 192 2.7e-12 conserved hypothetical protein [Pediculus humanus corporis]>gi|212508569|gb|EEB12217.1| conserved hypothetical protein [Pediculus humanus corporis] 642915784 XM_963085.2 121 1.80699e-54 PREDICTED: Tribolium castaneum cofilin/actin-depolymerizing factor homolog (LOC656560), mRNA K05765 CFL cofilin http://www.genome.jp/dbget-bin/www_bget?ko:K05765 P45594 186 5.5e-13 Cofilin/actin-depolymerizing factor homolog OS=Drosophila melanogaster GN=tsr PE=2 SV=1 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular -- -- Cluster-8309.46925 BF_2 11.44 0.64 1036 815803125 XP_012222257.1 355 4.6e-31 PREDICTED: glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2-like isoform X1 [Linepithema humile] 195391703 XM_002054464.1 69 2.01988e-25 Drosophila virilis GJ22773 (Dvir\GJ22773), mRNA K00820 glmS, GFPT glucosamine--fructose-6-phosphate aminotransferase (isomerizing) http://www.genome.jp/dbget-bin/www_bget?ko:K00820 Q9Z2Z9 277 2.1e-23 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2 OS=Mus musculus GN=Gfpt2 PE=2 SV=3 PF01380//PF13397 SIS domain//RNA polymerase-binding protein GO:0005975//GO:0045893 carbohydrate metabolic process//positive regulation of transcription, DNA-templated GO:0001000//GO:0030246 bacterial-type RNA polymerase core enzyme binding//carbohydrate binding -- -- KOG1268 Glucosamine 6-phosphate synthetases, contain amidotransferase and phosphosugar isomerase domains Cluster-8309.46926 BF_2 80.43 0.45 7699 642939018 XP_008198083.1 860 9.5e-89 PREDICTED: protein SCAF8 isoform X2 [Tribolium castaneum] 195123078 XM_002006001.1 64 9.28702e-22 Drosophila mojavensis GI18767 (Dmoj\GI18767), mRNA K13191 RBM16, SCAF8 RNA-binding protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13191 Q6DID3 568 2.8e-56 Protein SCAF8 OS=Mus musculus GN=Scaf8 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0132 RNA polymerase II C-terminal domain-binding protein RA4, contains RPR and RRM domains Cluster-8309.46928 BF_2 260.00 2.22 5197 478255927 ENN76129.1 1966 3.6e-217 hypothetical protein YQE_07349, partial [Dendroctonus ponderosae]>gi|546676523|gb|ERL87517.1| hypothetical protein D910_04909 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NRA2 315 4.1e-27 Sialin OS=Homo sapiens GN=SLC17A5 PE=1 SV=2 PF00379//PF07690 Insect cuticle protein//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0042302 structural constituent of cuticle GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.46929 BF_2 331.80 2.24 6482 642931680 XP_008196686.1 193 1.8e-11 PREDICTED: neurofilament heavy polypeptide-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46931 BF_2 13.00 1.77 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF04218 helix-turn-helix, Psq domain//CENP-B N-terminal DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.46932 BF_2 1606.00 12.38 5715 546677666 ERL88460.1 5013 0.0e+00 hypothetical protein D910_05846 [Dendroctonus ponderosae] -- -- -- -- -- K07207 TSC2 tuberous sclerosis 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07207 P49815 1939 2.2e-215 Tuberin OS=Homo sapiens GN=TSC2 PE=1 SV=2 PF02888//PF04088//PF02145//PF03542 Calmodulin binding domain//Peroxin 13, N-terminal region//Rap/ran-GAP//Tuberin GO:0043547//GO:0006813//GO:0051056//GO:0016560 positive regulation of GTPase activity//potassium ion transport//regulation of small GTPase mediated signal transduction//protein import into peroxisome matrix, docking GO:0005516//GO:0005096//GO:0015269 calmodulin binding//GTPase activator activity//calcium-activated potassium channel activity GO:0016021//GO:0005777 integral component of membrane//peroxisome KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.46936 BF_2 56.20 0.59 4269 478258345 ENN78464.1 1348 1.4e-145 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1005 3.3e-107 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF13304//PF01926//PF00005//PF03193 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter//Protein of unknown function, DUF258 GO:0006810//GO:0055085 transport//transmembrane transport GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.46940 BF_2 44.00 0.96 2214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46941 BF_2 227.00 5.89 1900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46944 BF_2 233.69 6.31 1836 642910469 XP_008200226.1 1009 1.2e-106 PREDICTED: uncharacterized protein LOC659133 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 242 4.3e-19 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.46948 BF_2 17.61 0.44 1972 332373528 AEE61905.1 453 3.8e-42 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46950 BF_2 4.00 51.33 227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46951 BF_2 8.00 1.57 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46952 BF_2 599.80 4.09 6428 642929205 XP_008195735.1 3696 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 560 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q9Y4E6 1822 9.2e-202 WD repeat-containing protein 7 OS=Homo sapiens GN=WDR7 PE=1 SV=2 PF07569//PF01506//PF00784//PF00400 TUP1-like enhancer of split//Hepatitis C virus non-structural 5a protein membrane anchor//MyTH4 domain//WD domain, G-beta repeat GO:0006144//GO:0006355//GO:0006508 purine nucleobase metabolic process//regulation of transcription, DNA-templated//proteolysis GO:0005515//GO:0004197//GO:0017111//GO:0004252//GO:0003968 protein binding//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0005634//GO:0005856//GO:0031379 nucleus//cytoskeleton//RNA-directed RNA polymerase complex KOG4155 FOG: WD40 repeat Cluster-8309.46953 BF_2 309.72 2.01 6740 642912146 XP_008200825.1 1113 3.8e-118 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNM6 504 6.5e-49 Protein FAM102A OS=Xenopus laevis GN=fam102a PE=2 SV=1 PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.46954 BF_2 887.65 20.03 2141 189238236 XP_972123.2 372 1.0e-32 PREDICTED: guanine nucleotide-binding protein subunit gamma-e [Tribolium castaneum]>gi|270008671|gb|EFA05119.1| hypothetical protein TcasGA2_TC015232 [Tribolium castaneum] 743280388 KM065747.1 140 1.44244e-64 Culex quinquefasciatus clone C2B G-protein gamma-subunit mRNA, complete cds K04547 GNG13 guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 http://www.genome.jp/dbget-bin/www_bget?ko:K04547 Q9NFZ3 335 8.2e-30 Guanine nucleotide-binding protein subunit gamma-e OS=Drosophila melanogaster GN=Ggamma30A PE=1 SV=1 PF00631//PF02501 GGL domain//Type II secretion system (T2SS), protein I GO:0007165//GO:0015031//GO:0015628//GO:0007186 signal transduction//protein transport//protein secretion by the type II secretion system//G-protein coupled receptor signaling pathway GO:0008565//GO:0004871 protein transporter activity//signal transducer activity GO:0005834//GO:0015627 heterotrimeric G-protein complex//type II protein secretion system complex KOG4119 G protein gamma subunit Cluster-8309.46956 BF_2 513.13 16.44 1593 478250645 ENN71137.1 1207 1.1e-129 hypothetical protein YQE_12068, partial [Dendroctonus ponderosae] -- -- -- -- -- K17525 CHID1 chitinase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17525 A0JPQ9 801 5.6e-84 Chitinase domain-containing protein 1 OS=Rattus norvegicus GN=Chid1 PE=2 SV=2 PF00704//PF03644 Glycosyl hydrolases family 18//Glycosyl hydrolase family 85 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0033925 hydrolase activity, hydrolyzing O-glycosyl compounds//mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity GO:0005737 cytoplasm KOG2091 Predicted member of glycosyl hydrolase family 18 Cluster-8309.46958 BF_2 42.87 0.40 4770 478255990 ENN76189.1 1139 2.6e-121 hypothetical protein YQE_07157, partial [Dendroctonus ponderosae] 755992161 XM_011314822.1 134 7.01638e-61 PREDICTED: Fopius arisanus succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial-like (LOC105272622), transcript variant X2, mRNA K01900 LSC2 succinyl-CoA synthetase beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01900 Q9Z2I9 710 6.0e-73 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial OS=Mus musculus GN=Sucla2 PE=1 SV=2 PF00583//PF00549 Acetyltransferase (GNAT) family//CoA-ligase GO:0008152//GO:0042967 metabolic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0008080 catalytic activity//N-acetyltransferase activity -- -- KOG2799 Succinyl-CoA synthetase, beta subunit Cluster-8309.46959 BF_2 53.51 0.64 3768 642915551 XP_008190663.1 1298 7.5e-140 PREDICTED: RNA-binding protein 25 isoform X2 [Tribolium castaneum] 572312960 XM_006622122.1 71 5.81211e-26 PREDICTED: Apis dorsata RNA-binding protein 25-like (LOC102681777), transcript variant X2, mRNA K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 522 3.0e-51 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.4696 BF_2 11.98 0.78 930 674304046 AIL23554.1 332 1.9e-28 microsomal glutathione S-transferase [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q91VS7 205 4.2e-15 Microsomal glutathione S-transferase 1 OS=Mus musculus GN=Mgst1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.46960 BF_2 1015.57 10.72 4251 642926413 XP_008191952.1 2942 0.0e+00 PREDICTED: uncharacterized protein LOC659527 isoform X1 [Tribolium castaneum] 827557070 XM_012694375.1 218 1.25991e-107 PREDICTED: Bombyx mori tau-tubulin kinase 1 (LOC101738454), transcript variant X3, mRNA K08815 TTBK tau tubulin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08815 Q6PCN3 1169 3.2e-126 Tau-tubulin kinase 1 OS=Mus musculus GN=Ttbk1 PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.46962 BF_2 524.46 4.55 5108 91087085 XP_974959.1 1184 1.7e-126 PREDICTED: phytepsin [Tribolium castaneum]>gi|270010541|gb|EFA06989.1| hypothetical protein TcasGA2_TC009950 [Tribolium castaneum] -- -- -- -- -- K01379 CTSD cathepsin D http://www.genome.jp/dbget-bin/www_bget?ko:K01379 Q03168 593 2.4e-59 Lysosomal aspartic protease OS=Aedes aegypti GN=AAEL006169 PE=1 SV=2 PF03145//PF01186//PF02176//PF00026 Seven in absentia protein family//Lysyl oxidase//TRAF-type zinc finger//Eukaryotic aspartyl protease GO:0055114//GO:0006508//GO:0006511//GO:0007275 oxidation-reduction process//proteolysis//ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270//GO:0016641//GO:0004190//GO:0005507 zinc ion binding//oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//aspartic-type endopeptidase activity//copper ion binding GO:0005634 nucleus KOG1339 Aspartyl protease Cluster-8309.46963 BF_2 1158.07 20.38 2664 189236857 XP_974302.2 1925 1.1e-212 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum] 541975047 XM_005440594.1 35 4.21317e-06 PREDICTED: Falco cherrug solute carrier family 36 (proton/amino acid symporter), member 1 (SLC36A1), mRNA K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q4KL91 842 1.6e-88 Proton-coupled amino acid transporter 4 OS=Xenopus laevis GN=slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.46965 BF_2 121.25 1.42 3871 572098878 AHF48760.1 2078 2.8e-230 mitochondrial arginyl-tRNA synthetase [Caryedes brasiliensis] 874501526 XM_013108851.1 55 4.68283e-17 PREDICTED: Anas platyrhynchos mitochondrial ribosomal protein S9 (MRPS9), mRNA K01887 RARS, argS arginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01887 Q0P5H7 921 1.7e-97 Probable arginine--tRNA ligase, mitochondrial OS=Bos taurus GN=RARS2 PE=2 SV=1 PF00750//PF00380//PF05746 tRNA synthetases class I (R)//Ribosomal protein S9/S16//DALR anticodon binding domain GO:0006525//GO:0006412//GO:0006560//GO:0006420//GO:0042254 arginine metabolic process//translation//proline metabolic process//arginyl-tRNA aminoacylation//ribosome biogenesis GO:0005524//GO:0004814//GO:0003735 ATP binding//arginine-tRNA ligase activity//structural constituent of ribosome GO:0005840 ribosome KOG1195 Arginyl-tRNA synthetase Cluster-8309.46966 BF_2 62.09 0.77 3673 642922521 XP_008193210.1 3245 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1353 1.3e-147 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF00514//PF02985 Armadillo/beta-catenin-like repeat//HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.46972 BF_2 65.63 1.91 1728 332375352 AEE62817.1 223 1.6e-15 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46974 BF_2 73.68 2.41 1566 91079959 XP_969470.1 510 7.4e-49 PREDICTED: three-prime repair exonuclease 1 [Tribolium castaneum]>gi|270003252|gb|EEZ99699.1| hypothetical protein TcasGA2_TC002459 [Tribolium castaneum] -- -- -- -- -- K10791 TREX2 three prime repair exonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10791 Q9R1A9 252 2.5e-20 Three prime repair exonuclease 2 OS=Mus musculus GN=Trex2 PE=2 SV=1 PF13482//PF03104 RNase_H superfamily//DNA polymerase family B, exonuclease domain -- -- GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- -- -- Cluster-8309.46975 BF_2 15.95 0.50 1632 478255105 ENN75335.1 604 9.7e-60 hypothetical protein YQE_08111, partial [Dendroctonus ponderosae]>gi|546680135|gb|ERL90476.1| hypothetical protein D910_07825 [Dendroctonus ponderosae] 766923225 XM_011507925.1 57 1.50796e-18 PREDICTED: Ceratosolen solmsi marchali uracil phosphoribosyltransferase homolog (LOC105368798), transcript variant X2, mRNA K00761 upp, UPRT uracil phosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00761 Q6NYU7 450 2.9e-43 Uracil phosphoribosyltransferase homolog OS=Danio rerio GN=uprt PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.46977 BF_2 183.05 3.55 2444 642935245 XP_008197928.1 1930 2.5e-213 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 311 1.44245e-159 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 828 6.4e-87 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895//PF05790 Immunoglobulin domain//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.46979 BF_2 20.10 0.77 1374 642923549 XP_008193554.1 984 7.1e-104 PREDICTED: zinc finger and SCAN domain-containing protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5VIY5 333 8.9e-30 Zinc finger protein 468 OS=Homo sapiens GN=ZNF468 PE=2 SV=1 PF13912//PF00960//PF02178//PF00096//PF13465//PF00982 C2H2-type zinc finger//Neocarzinostatin family//AT hook motif//Zinc finger, C2H2 type//Zinc-finger double domain//Glycosyltransferase family 20 GO:0005992//GO:0006952 trehalose biosynthetic process//defense response GO:0046872//GO:0003677//GO:0003824 metal ion binding//DNA binding//catalytic activity -- -- -- -- Cluster-8309.46981 BF_2 754.11 7.02 4784 332372957 AEE61620.1 2271 1.4e-252 unknown [Dendroctonus ponderosae] 242003777 XM_002422811.1 148 1.16102e-68 Pediculus humanus corporis conserved hypothetical protein, mRNA K11142 LAP3 cytosol aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11142 P00727 1029 6.1e-110 Cytosol aminopeptidase OS=Bos taurus GN=LAP3 PE=1 SV=3 PF02789//PF04140//PF02544//PF00883 Cytosol aminopeptidase family, N-terminal domain//Isoprenylcysteine carboxyl methyltransferase (ICMT) family//3-oxo-5-alpha-steroid 4-dehydrogenase//Cytosol aminopeptidase family, catalytic domain GO:0006629//GO:0006481//GO:0006508//GO:0006479 lipid metabolic process//C-terminal protein methylation//proteolysis//protein methylation GO:0004177//GO:0004671//GO:0016627 aminopeptidase activity//protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005622//GO:0005737 integral component of membrane//intracellular//cytoplasm -- -- Cluster-8309.46983 BF_2 645.71 7.33 3971 642919697 XP_008192026.1 4505 0.0e+00 PREDICTED: putative ATP-dependent RNA helicase DHX57 [Tribolium castaneum]>gi|270005433|gb|EFA01881.1| hypothetical protein TcasGA2_TC007486 [Tribolium castaneum] -- -- -- -- -- K13026 DHX57 ATP-dependent RNA helicase DHX57 http://www.genome.jp/dbget-bin/www_bget?ko:K13026 Q6P158 2493 8.8e-280 Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2 PF00270//PF00437//PF04408//PF00642//PF05773//PF00005 DEAD/DEAH box helicase//Type II/IV secretion system protein//Helicase associated domain (HA2)//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//RWD domain//ABC transporter GO:0006810 transport GO:0008270//GO:0016887//GO:0003676//GO:0046872//GO:0004386//GO:0005524//GO:0008026//GO:0005515 zinc ion binding//ATPase activity//nucleic acid binding//metal ion binding//helicase activity//ATP binding//ATP-dependent helicase activity//protein binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.46984 BF_2 85.12 0.93 4113 642923221 XP_008193661.1 1362 3.1e-147 PREDICTED: uncharacterized protein LOC103313092 [Tribolium castaneum] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q6DF07 344 1.4e-30 Programmed cell death protein 10 OS=Xenopus tropicalis GN=pdcd10 PE=2 SV=1 PF09815//PF00863//PF04048 XK-related protein//Peptidase family C4//Sec8 exocyst complex component specific domain GO:0006904//GO:0015031//GO:0006508 vesicle docking involved in exocytosis//protein transport//proteolysis GO:0008234 cysteine-type peptidase activity GO:0016021//GO:0000145 integral component of membrane//exocyst KOG4025 Putative apoptosis related protein Cluster-8309.46985 BF_2 155.84 1.73 4064 642923221 XP_008193661.1 1362 3.1e-147 PREDICTED: uncharacterized protein LOC103313092 [Tribolium castaneum] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q8AVR4 477 5.3e-46 Programmed cell death protein 10 OS=Xenopus laevis GN=pdcd10 PE=2 SV=1 PF00669//PF00863//PF09815 Bacterial flagellin N-terminal helical region//Peptidase family C4//XK-related protein GO:0006508//GO:0071973 proteolysis//bacterial-type flagellum-dependent cell motility GO:0008234//GO:0005198 cysteine-type peptidase activity//structural molecule activity GO:0016021 integral component of membrane KOG4025 Putative apoptosis related protein Cluster-8309.46986 BF_2 14.36 0.31 2199 642929609 XP_008195902.1 2244 8.9e-250 PREDICTED: FAS-associated factor 1 [Tribolium castaneum]>gi|270011090|gb|EFA07538.1| Fas (TNFRSF6) associated factor 1 [Tribolium castaneum] 642929608 XM_008197680.1 179 3.09682e-86 PREDICTED: Tribolium castaneum FAS-associated factor 1 (LOC664346), mRNA -- -- -- -- Q9UNN5 941 4.5e-100 FAS-associated factor 1 OS=Homo sapiens GN=FAF1 PE=1 SV=2 PF00789//PF00240//PF00430//PF05279 UBX domain//Ubiquitin family//ATP synthase B/B' CF(0)//Aspartyl beta-hydroxylase N-terminal region GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078//GO:0005515 hydrogen ion transmembrane transporter activity//protein binding GO:0045263//GO:0016020 proton-transporting ATP synthase complex, coupling factor F(o)//membrane KOG1363 Predicted regulator of the ubiquitin pathway (contains UAS and UBX domains) Cluster-8309.46988 BF_2 22.48 0.70 1624 270001943 EEZ98390.1 619 1.8e-61 hypothetical protein TcasGA2_TC000854 [Tribolium castaneum] 642913080 XM_008203160.1 234 6.05971e-117 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X6, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 317 7.6e-28 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.46989 BF_2 23.00 5.06 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46990 BF_2 39.00 9.11 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.46991 BF_2 182.40 2.10 3923 642940154 XP_008194847.1 1161 6.0e-124 PREDICTED: myoneurin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 345 1.0e-30 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF02714//PF00651 Calcium-dependent channel, 7TM region, putative phosphate//BTB/POZ domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.46992 BF_2 93.95 1.43 3036 642940156 XP_008194851.1 1063 1.1e-112 PREDICTED: myoneurin-like isoform X3 [Tribolium castaneum]>gi|642940158|ref|XP_008194859.1| PREDICTED: myoneurin-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 335 1.2e-29 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF02714//PF00651//PF01527 Calcium-dependent channel, 7TM region, putative phosphate//BTB/POZ domain//Transposase GO:0006313 transposition, DNA-mediated GO:0004803//GO:0005515//GO:0003677 transposase activity//protein binding//DNA binding GO:0016020 membrane -- -- Cluster-8309.46993 BF_2 34.30 0.71 2304 189237223 XP_969624.2 1426 6.6e-155 PREDICTED: 45 kDa calcium-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZKE5 310 7.0e-27 45 kDa calcium-binding protein OS=Gallus gallus GN=SDF4 PE=2 SV=2 PF12763//PF13202//PF13499//PF13833//PF00036//PF13405 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG4251 Calcium binding protein Cluster-8309.46994 BF_2 569.04 20.28 1461 642912660 XP_008200953.1 1394 2.2e-151 PREDICTED: aldose reductase-like [Tribolium castaneum]>gi|270002625|gb|EEZ99072.1| hypothetical protein TcasGA2_TC004950 [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P07943 758 5.0e-79 Aldose reductase OS=Rattus norvegicus GN=Akr1b1 PE=1 SV=3 -- -- GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.46996 BF_2 7.02 0.70 705 546672817 ERL84573.1 256 9.4e-20 hypothetical protein D910_02002 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q76DI2 180 2.5e-12 Beta-1,3-glucan-binding protein OS=Tenebrio molitor GN=GRP PE=1 SV=1 PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.46999 BF_2 36.77 0.67 2585 270015561 EFA12009.1 732 2.2e-74 hypothetical protein TcasGA2_TC016134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06403 Lamprin -- -- GO:0005198 structural molecule activity GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.47001 BF_2 230.68 1.77 5727 642929059 XP_008195674.1 2839 0.0e+00 PREDICTED: A-agglutinin anchorage subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9S0 859 3.8e-90 MTSS1-like protein OS=Mus musculus GN=Mtss1l PE=1 SV=1 PF14980//PF02205//PF08397 TIP39 peptide//WH2 motif//IRSp53/MIM homology domain GO:0007218//GO:0007009 neuropeptide signaling pathway//plasma membrane organization GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.47002 BF_2 93.78 0.84 4962 -- -- -- -- -- 642916579 XM_008193556.1 49 1.30202e-13 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein L (LOC657712), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47003 BF_2 117.06 0.55 9111 478259419 ENN79309.1 1279 2.9e-137 hypothetical protein YQE_04219, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P42260 843 4.3e-88 Glutamate receptor ionotropic, kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.47004 BF_2 1029.82 13.46 3488 270007542 EFA03990.1 2206 3.6e-245 hypothetical protein TcasGA2_TC014139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB0 1005 2.7e-107 MAGUK p55 subfamily member 6 OS=Mus musculus GN=Mpp6 PE=1 SV=1 PF13180//PF03193//PF14604//PF00018//PF00595 PDZ domain//Protein of unknown function, DUF258//Variant SH3 domain//SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005525//GO:0005515//GO:0003924 GTP binding//protein binding//GTPase activity -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.47008 BF_2 587.88 1.61 15567 642934439 XP_008197663.1 5485 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.79075e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1486 2.0e-162 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00155//PF02178//PF13639//PF12125//PF00439//PF16866//PF00628//PF00202 Aminotransferase class I and II//AT hook motif//Ring finger domain//D domain of beta-TrCP//Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III GO:0009058 biosynthetic process GO:0003677//GO:0008270//GO:0008483//GO:0005515//GO:0046983//GO:0030170 DNA binding//zinc ion binding//transaminase activity//protein binding//protein dimerization activity//pyridoxal phosphate binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.47009 BF_2 697.26 1.91 15581 642934439 XP_008197663.1 5552 0.0e+00 PREDICTED: nucleosome-remodeling factor subunit NURF301 isoform X2 [Tribolium castaneum] 242013552 XM_002427424.1 127 1.79236e-56 Pediculus humanus corporis fetal alzheimer antigen, falz, putative, mRNA K13524 ABAT 4-aminobutyrate aminotransferase / (S)-3-amino-2-methylpropionate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K13524 Q9W0T1 1507 7.5e-165 Nucleosome-remodeling factor subunit NURF301 OS=Drosophila melanogaster GN=E(bx) PE=1 SV=2 PF00439//PF00628//PF16866//PF00202//PF02178//PF00155//PF13639//PF12125 Bromodomain//PHD-finger//PHD-finger//Aminotransferase class-III//AT hook motif//Aminotransferase class I and II//Ring finger domain//D domain of beta-TrCP GO:0009058 biosynthetic process GO:0008270//GO:0003677//GO:0046983//GO:0030170//GO:0008483//GO:0005515 zinc ion binding//DNA binding//protein dimerization activity//pyridoxal phosphate binding//transaminase activity//protein binding -- -- KOG1405 4-aminobutyrate aminotransferase Cluster-8309.47011 BF_2 1970.86 31.27 2924 91094595 XP_970633.1 1466 1.9e-159 PREDICTED: cytochrome P450 6k1 [Tribolium castaneum]>gi|270016411|gb|EFA12857.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 966 7.6e-103 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0046872//GO:0016491//GO:0005506//GO:0020037//GO:0016705 metal ion binding//oxidoreductase activity//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.47013 BF_2 458.75 5.00 4123 642926286 XP_008194862.1 2731 5.6e-306 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror-like [Tribolium castaneum] 642926285 XM_008196640.1 273 3.25548e-138 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1579 8.8e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF07714//PF01392//PF00069 Protein tyrosine kinase//Fz domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.47021 BF_2 2453.95 35.17 3206 642922662 XP_008193267.1 1184 1.1e-126 PREDICTED: cytochrome P450 4c3-like [Tribolium castaneum]>gi|270008167|gb|EFA04615.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 867 2.5e-91 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067//PF12822 Cytochrome P450//Protein of unknown function (DUF3816) GO:0055114//GO:0006810 oxidation-reduction process//transport GO:0016705//GO:0020037//GO:0005215//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//transporter activity//iron ion binding -- -- -- -- Cluster-8309.47022 BF_2 32.22 1.59 1133 642921027 XP_008192660.1 721 1.8e-73 PREDICTED: protein kinase C-binding protein NELL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92832 278 1.8e-23 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47023 BF_2 769.21 20.48 1858 642919704 XP_008192030.1 1785 1.3e-196 PREDICTED: serine/threonine-protein kinase SIK2 [Tribolium castaneum]>gi|270005428|gb|EFA01876.1| hypothetical protein TcasGA2_TC007481 [Tribolium castaneum] 807042760 XM_012306425.1 116 2.74128e-51 PREDICTED: Ceratitis capitata serine/threonine-protein kinase par-1 (LOC101453227), transcript variant X3, mRNA K16311 SIK2 serine/threonine-protein kinase SIK2 http://www.genome.jp/dbget-bin/www_bget?ko:K16311 Q9H0K1 1243 3.6e-135 Serine/threonine-protein kinase SIK2 OS=Homo sapiens GN=SIK2 PE=1 SV=1 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0016773//GO:0004672//GO:0004674 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.47025 BF_2 127.35 0.63 8714 642937185 XP_008198729.1 2693 3.0e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 4.68986e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.9e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF05192//PF00856//PF00995//PF00023//PF11744//PF05033//PF02068//PF13606 MutS domain III//SET domain//Sec1 family//Ankyrin repeat//Aluminium activated malate transporter//Pre-SET motif//Plant PEC family metallothionein//Ankyrin repeat GO:0006554//GO:0006479//GO:0016192//GO:0034968//GO:0015743//GO:0006904//GO:0006298 lysine catabolic process//protein methylation//vesicle-mediated transport//histone lysine methylation//malate transport//vesicle docking involved in exocytosis//mismatch repair GO:0030983//GO:0008270//GO:0005515//GO:0018024//GO:0005524 mismatched DNA binding//zinc ion binding//protein binding//histone-lysine N-methyltransferase activity//ATP binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.47026 BF_2 1.00 0.55 360 642937128 XP_008198704.1 253 1.1e-19 PREDICTED: histone-lysine N-methyltransferase EHMT2 [Tribolium castaneum] -- -- -- -- -- K11420 EHMT euchromatic histone-lysine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11420 Q9Z148 154 1.3e-09 Histone-lysine N-methyltransferase EHMT2 OS=Mus musculus GN=Ehmt2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47027 BF_2 143.17 1.01 6226 270012280 EFA08728.1 711 1.5e-71 hypothetical protein TcasGA2_TC006403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80VL1 172 1.9e-10 Tudor and KH domain-containing protein OS=Mus musculus GN=Tdrkh PE=1 SV=1 PF04277//PF15802 Oxaloacetate decarboxylase, gamma chain//DDB1- and CUL4-associated factor 17 GO:0016567//GO:0006560//GO:0006525//GO:0006814//GO:0071436//GO:0006090 protein ubiquitination//proline metabolic process//arginine metabolic process//sodium ion transport//sodium ion export//pyruvate metabolic process GO:0008948//GO:0015081 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.47029 BF_2 360.91 13.71 1388 546676966 ERL87890.1 603 1.1e-59 hypothetical protein D910_05278 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47032 BF_2 748.54 16.77 2154 270001223 EEZ97670.1 186 3.8e-11 hypothetical protein TcasGA2_TC016215 [Tribolium castaneum] 642937522 XM_008200859.1 67 5.52392e-24 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47034 BF_2 432.42 4.73 4112 91087255 XP_975528.1 1116 1.0e-118 PREDICTED: transmembrane protein 110 [Tribolium castaneum]>gi|270009551|gb|EFA05999.1| hypothetical protein TcasGA2_TC008825 [Tribolium castaneum] 847108462 XR_001170156.1 36 1.8156e-06 PREDICTED: Xenopus (Silurana) tropicalis transmembrane protein 110 (tmem110), transcript variant X1, misc_RNA -- -- -- -- Q86TL2 556 3.7e-55 Transmembrane protein 110 OS=Homo sapiens GN=TMEM110 PE=2 SV=1 PF01708//PF01529 Geminivirus putative movement protein//DHHC palmitoyltransferase GO:0046740 transport of virus in host, cell to cell GO:0008270 zinc ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.47035 BF_2 28.52 0.55 2469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47037 BF_2 69.27 0.58 5322 91088913 XP_973082.1 2046 2.0e-226 PREDICTED: uncharacterized protein KIAA0556-like [Tribolium castaneum] 551546037 XM_005760895.1 51 1.08009e-14 Emiliania huxleyi CCMP1516 glutamine amidotransferase partial mRNA K01951 guaA, GMPS GMP synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01951 Q4V7C6 1376 4.0e-150 GMP synthase [glutamine-hydrolyzing] OS=Rattus norvegicus GN=Gmps PE=1 SV=1 PF02568//PF07722//PF00764//PF08131//PF00733//PF07685//PF01507 Thiamine biosynthesis protein (ThiI)//Peptidase C26//Arginosuccinate synthase//Defensin-like peptide family//Asparagine synthase//CobB/CobQ-like glutamine amidotransferase domain//Phosphoadenosine phosphosulfate reductase family GO:0006526//GO:0008033//GO:0009236//GO:0006541//GO:0006560//GO:0006531//GO:0006529//GO:0008152//GO:0006522 arginine biosynthetic process//tRNA processing//cobalamin biosynthetic process//glutamine metabolic process//proline metabolic process//aspartate metabolic process//asparagine biosynthetic process//metabolic process//alanine metabolic process GO:0016787//GO:0005524//GO:0004055//GO:0003824//GO:0004810//GO:0004066 hydrolase activity//ATP binding//argininosuccinate synthase activity//catalytic activity//tRNA adenylyltransferase activity//asparagine synthase (glutamine-hydrolyzing) activity GO:0005576 extracellular region KOG1622 GMP synthase Cluster-8309.47038 BF_2 243.13 1.93 5565 167234451 NP_001107840.1 4552 0.0e+00 Dicer-2 [Tribolium castaneum]>gi|642913971|ref|XP_008201496.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|642913973|ref|XP_008201497.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|270002830|gb|EEZ99277.1| hypothetical protein TcasGA2_TC001108 [Tribolium castaneum] 642913972 XM_008203275.1 50 4.06326e-14 PREDICTED: Tribolium castaneum Dicer-2 (Dcr-2), transcript variant X2, mRNA -- -- -- -- P34529 1074 4.3e-115 Endoribonuclease dcr-1 OS=Caenorhabditis elegans GN=dcr-1 PE=1 SV=3 PF00636//PF03368//PF04851//PF02170//PF14622//PF00270 Ribonuclease III domain//Dicer dimerisation domain//Type III restriction enzyme, res subunit//PAZ domain//Ribonuclease-III-like//DEAD/DEAH box helicase GO:0034470//GO:0051252//GO:0006396//GO:0016072 ncRNA processing//regulation of RNA metabolic process//RNA processing//rRNA metabolic process GO:0005515//GO:0004386//GO:0003723//GO:0005524//GO:0016787//GO:0003677//GO:0004525//GO:0043167//GO:0016891//GO:0003676 protein binding//helicase activity//RNA binding//ATP binding//hydrolase activity//DNA binding//ribonuclease III activity//ion binding//endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding -- -- KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.47039 BF_2 837.26 7.76 4802 189235133 XP_966882.2 3063 0.0e+00 PREDICTED: EH domain-binding protein 1 isoform X1 [Tribolium castaneum]>gi|270003802|gb|EFA00250.1| hypothetical protein TcasGA2_TC003079 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NDI1 547 4.8e-54 EH domain-binding protein 1 OS=Homo sapiens GN=EHBP1 PE=1 SV=3 PF05366//PF00307 Sarcolipin//Calponin homology (CH) domain -- -- GO:0005515//GO:0030234 protein binding//enzyme regulator activity GO:0016020 membrane -- -- Cluster-8309.47041 BF_2 222.00 3.48 2955 642930268 XP_008196323.1 2286 1.6e-254 PREDICTED: digestive organ expansion factor homolog [Tribolium castaneum]>gi|270009436|gb|EFA05884.1| hypothetical protein TcasGA2_TC008696 [Tribolium castaneum] -- -- -- -- -- K14774 UTP25, DEF U3 small nucleolar RNA-associated protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K14774 Q68CQ4 1490 1.3e-163 Digestive organ expansion factor homolog OS=Homo sapiens GN=DIEXF PE=1 SV=2 PF06862 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 -- -- -- -- GO:0005634 nucleus KOG2340 Uncharacterized conserved protein Cluster-8309.47044 BF_2 149.23 3.80 1932 91082667 XP_966596.1 342 2.8e-29 PREDICTED: uncharacterized protein LOC659832 [Tribolium castaneum]>gi|270014970|gb|EFA11418.1| hypothetical protein TcasGA2_TC013595 [Tribolium castaneum] 642910857 XM_961503.3 73 2.28456e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659832 (LOC659832), mRNA -- -- -- -- -- -- -- -- PF05808 Podoplanin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47045 BF_2 19.00 3.31 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47046 BF_2 37.71 0.81 2239 478256087 ENN76286.1 2299 3.8e-256 hypothetical protein YQE_07249, partial [Dendroctonus ponderosae]>gi|546675828|gb|ERL86933.1| hypothetical protein D910_04336 [Dendroctonus ponderosae] -- -- -- -- -- K01953 asnB, ASNS asparagine synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01953 Q5ZJU3 1467 4.7e-161 Asparagine synthetase [glutamine-hydrolyzing] OS=Gallus gallus GN=ASNS PE=2 SV=3 PF00733//PF00764//PF02568 Asparagine synthase//Arginosuccinate synthase//Thiamine biosynthesis protein (ThiI) GO:0006526//GO:0006529//GO:0006531//GO:0006560//GO:0006522//GO:0008033 arginine biosynthetic process//asparagine biosynthetic process//aspartate metabolic process//proline metabolic process//alanine metabolic process//tRNA processing GO:0005524//GO:0004810//GO:0004055//GO:0004066 ATP binding//tRNA adenylyltransferase activity//argininosuccinate synthase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0571 Asparagine synthase (glutamine-hydrolyzing) Cluster-8309.47047 BF_2 10.09 0.41 1321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47048 BF_2 343.27 3.77 4100 642930410 XP_008196388.1 3749 0.0e+00 PREDICTED: presequence protease, mitochondrial [Tribolium castaneum]>gi|270010721|gb|EFA07169.1| hypothetical protein TcasGA2_TC010168 [Tribolium castaneum] -- -- -- -- -- K06972 K06972 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06972 Q9V9E3 2309 2.0e-258 Presequence protease, mitochondrial OS=Drosophila melanogaster GN=CG3107 PE=2 SV=2 PF08397//PF08367 IRSp53/MIM homology domain//Peptidase M16C associated GO:0006508//GO:0007009 proteolysis//plasma membrane organization GO:0008270//GO:0004222//GO:0046872 zinc ion binding//metalloendopeptidase activity//metal ion binding -- -- KOG2019 Metalloendoprotease HMP1 (insulinase superfamily) Cluster-8309.47049 BF_2 220.96 11.82 1069 759001854 AJP08639.1 1203 2.2e-129 c-Jun N-terminal kinase [Microdera dzhungarica] 817204830 XM_012422883.1 317 2.86391e-163 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X1, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1096 2.3e-118 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF06293//PF00069//PF03242 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Late embryogenesis abundant protein GO:0006950//GO:0006468 response to stress//protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.47051 BF_2 267.00 12.84 1157 189238165 XP_973195.2 374 3.2e-33 PREDICTED: serine protease gd-like [Tribolium castaneum]>gi|642925379|ref|XP_008194524.1| PREDICTED: serine protease gd-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47052 BF_2 220.86 4.57 2311 642933063 XP_008197247.1 1689 2.1e-185 PREDICTED: rab GTPase-binding effector protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O35551 370 7.7e-34 Rab GTPase-binding effector protein 1 OS=Mus musculus GN=Rabep1 PE=1 SV=2 PF03528 Rabaptin GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0005096//GO:0008083 GTPase activator activity//growth factor activity -- -- KOG0993 Rab5 GTPase effector Rabaptin-5 Cluster-8309.47053 BF_2 8.00 0.43 1058 225543480 NP_001139387.1 525 9.1e-51 cuticular protein-like precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.47054 BF_2 311.26 3.38 4140 546686080 ERL95480.1 797 1.0e-81 hypothetical protein D910_12742 [Dendroctonus ponderosae] -- -- -- -- -- K03434 PIGL N-acetylglucosaminylphosphatidylinositol deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K03434 Q9Y2B2 434 5.2e-41 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Homo sapiens GN=PIGL PE=1 SV=1 PF04144 SCAMP family GO:0015031 protein transport -- -- GO:0016021 integral component of membrane KOG3332 N-acetylglucosaminyl phosphatidylinositol de-N-acetylase Cluster-8309.47055 BF_2 1178.85 44.72 1390 91081285 XP_967895.1 685 3.4e-69 PREDICTED: soma ferritin [Tribolium castaneum]>gi|270005213|gb|EFA01661.1| hypothetical protein TcasGA2_TC007233 [Tribolium castaneum] -- -- -- -- -- K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P42577 552 3.6e-55 Soma ferritin OS=Lymnaea stagnalis PE=2 SV=2 PF00210//PF02915 Ferritin-like domain//Rubrerythrin GO:0006826//GO:0055114//GO:0006879 iron ion transport//oxidation-reduction process//cellular iron ion homeostasis GO:0016491//GO:0046872//GO:0008199 oxidoreductase activity//metal ion binding//ferric iron binding -- -- KOG2332 Ferritin Cluster-8309.47057 BF_2 80.86 0.89 4074 478249815 ENN70322.1 784 3.3e-80 hypothetical protein YQE_12833, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PR54 158 5.2e-09 Telomere-associated protein RIF1 OS=Mus musculus GN=Rif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47061 BF_2 148.91 1.78 3785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.47063 BF_2 66.04 1.55 2065 571330974 AHF27419.1 1063 7.3e-113 putative sugar transporter 5 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A9ZSY2 627 1.1e-63 Facilitated trehalose transporter Tret1 OS=Apis mellifera ligustica GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.47064 BF_2 721.57 13.70 2491 817182773 XP_012272816.1 326 2.6e-27 PREDICTED: uncharacterized protein LOC105695640 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15957 Commissureless GO:0007411 axon guidance -- -- -- -- -- -- Cluster-8309.47066 BF_2 71.71 0.98 3335 642914128 XP_008201556.1 3030 0.0e+00 PREDICTED: colorectal mutant cancer protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 586 1.0e-58 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 PF00404//PF13405//PF00036//PF13499//PF13202 Dockerin type I repeat//EF-hand domain//EF hand//EF-hand domain pair//EF hand GO:0005975 carbohydrate metabolic process GO:0004553//GO:0005509 hydrolase activity, hydrolyzing O-glycosyl compounds//calcium ion binding -- -- -- -- Cluster-8309.47068 BF_2 467.09 2.69 7549 642935854 XP_008198199.1 3978 0.0e+00 PREDICTED: importin-13 [Tribolium castaneum]>gi|270013261|gb|EFA09709.1| hypothetical protein TcasGA2_TC011842 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K0C1 1357 9.0e-148 Importin-13 OS=Mus musculus GN=Ipo13 PE=2 SV=1 PF00071//PF02421//PF01926//PF07817//PF03810//PF08477//PF03193 Ras family//Ferrous iron transport protein B//50S ribosome-binding GTPase//GLE1-like protein//Importin-beta N-terminal domain//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258 GO:0007264//GO:0015684//GO:0015031//GO:0016973//GO:0006886 small GTPase mediated signal transduction//ferrous iron transport//protein transport//poly(A)+ mRNA export from nucleus//intracellular protein transport GO:0005525//GO:0008565//GO:0015093//GO:0008536//GO:0003924 GTP binding//protein transporter activity//ferrous iron transmembrane transporter activity//Ran GTPase binding//GTPase activity GO:0005643//GO:0016021 nuclear pore//integral component of membrane KOG3068 mRNA splicing factor Cluster-8309.47069 BF_2 38.74 1.50 1365 642910295 XP_008200272.1 367 2.5e-32 PREDICTED: beta-N-acetylglucosaminidase NAG2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 P49010 294 3.0e-25 Chitooligosaccharidolytic beta-N-acetylglucosaminidase OS=Bombyx mori PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.47071 BF_2 900.42 23.99 1857 642925685 XP_008194669.1 1435 4.8e-156 PREDICTED: aminomethyltransferase, mitochondrial [Tribolium castaneum]>gi|270008909|gb|EFA05357.1| hypothetical protein TcasGA2_TC015522 [Tribolium castaneum] -- -- -- -- -- K00605 gcvT, AMT aminomethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00605 P25285 942 2.9e-100 Aminomethyltransferase, mitochondrial OS=Bos taurus GN=AMT PE=1 SV=1 -- -- GO:0006544//GO:0006546//GO:0006566//GO:0006563 glycine metabolic process//glycine catabolic process//threonine metabolic process//L-serine metabolic process GO:0008483//GO:0004047 transaminase activity//aminomethyltransferase activity GO:0005737 cytoplasm KOG2770 Aminomethyl transferase Cluster-8309.47075 BF_2 519.63 10.60 2338 478253832 ENN74124.1 1593 2.9e-174 hypothetical protein YQE_09097, partial [Dendroctonus ponderosae]>gi|546684638|gb|ERL94255.1| hypothetical protein D910_11536 [Dendroctonus ponderosae] 749785289 XM_011148089.1 84 2.12893e-33 PREDICTED: Harpegnathos saltator probable E3 ubiquitin-protein ligase makorin-1 (LOC105187344), mRNA K15687 MKRN E3 ubiquitin-protein ligase makorin http://www.genome.jp/dbget-bin/www_bget?ko:K15687 Q5NU14 754 2.3e-78 Probable E3 ubiquitin-protein ligase makorin-1 OS=Takifugu rubripes GN=mkrn1 PE=2 SV=1 PF14634//PF12861//PF12678//PF00642//PF00097//PF16954//PF13639 zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Zinc finger, C3HC4 type (RING finger)//Haem-transporter, endosomal/lysosomal, haem-responsive gene//Ring finger domain GO:0016567//GO:0015886 protein ubiquitination//heme transport GO:0005515//GO:0004842//GO:0015232//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//heme transporter activity//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG1039 Predicted E3 ubiquitin ligase Cluster-8309.47076 BF_2 481.03 1.97 10509 91088841 XP_970807.1 2162 1.4e-239 PREDICTED: histone acetyltransferase KAT6B isoform X1 [Tribolium castaneum]>gi|270012338|gb|EFA08786.1| hypothetical protein TcasGA2_TC006477 [Tribolium castaneum] 688437395 LL190970.1 59 7.63921e-19 Heligmosomoides polygyrus genome assembly H_bakeri_Edinburgh ,scaffold HPBE_scaffold0002591 K11306 MYST4, KAT6B histone acetyltransferase MYST4 http://www.genome.jp/dbget-bin/www_bget?ko:K11306 Q8BRB7 1032 6.0e-110 Histone acetyltransferase KAT6B OS=Mus musculus GN=Kat6b PE=1 SV=3 PF00628//PF00538//PF01853//PF06431//PF01160//PF13508 PHD-finger//linker histone H1 and H5 family//MOZ/SAS family//Polyomavirus large T antigen C-terminus//Vertebrate endogenous opioids neuropeptide//Acetyltransferase (GNAT) domain GO:0042967//GO:0006334//GO:0007218//GO:0006260//GO:0006355 acyl-carrier-protein biosynthetic process//nucleosome assembly//neuropeptide signaling pathway//DNA replication//regulation of transcription, DNA-templated GO:0005515//GO:0008080//GO:0003677//GO:0005524//GO:0016747//GO:0005488 protein binding//N-acetyltransferase activity//DNA binding//ATP binding//transferase activity, transferring acyl groups other than amino-acyl groups//binding GO:0000786//GO:0005634 nucleosome//nucleus KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.47077 BF_2 374.09 3.23 5128 91083351 XP_975052.1 2637 5.6e-295 PREDICTED: gamma-tubulin complex component 3 [Tribolium castaneum]>gi|270007769|gb|EFA04217.1| hypothetical protein TcasGA2_TC014466 [Tribolium castaneum] -- -- -- -- -- K16570 TUBGCP3, GCP3 gamma-tubulin complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16570 P58854 1192 8.3e-129 Gamma-tubulin complex component 3 OS=Mus musculus GN=Tubgcp3 PE=2 SV=2 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226 positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0005815//GO:0000922//GO:0044430//GO:0015630 microtubule organizing center//spindle pole//cytoskeletal part//microtubule cytoskeleton KOG2000 Gamma-tubulin complex, DGRIP91/SPC98 component Cluster-8309.47079 BF_2 427.53 3.83 4958 91088253 XP_966567.1 1655 4.0e-181 PREDICTED: ankyrin repeat and zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270012152|gb|EFA08600.1| hypothetical protein TcasGA2_TC006259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPJ0 627 2.6e-63 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF13606//PF00023//PF01553//PF15306 Ankyrin repeat//Ankyrin repeat//Acyltransferase//LIN37 GO:0008152//GO:0007049 metabolic process//cell cycle GO:0005515//GO:0016746 protein binding//transferase activity, transferring acyl groups GO:0017053 transcriptional repressor complex KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.47080 BF_2 653.95 6.02 4829 91088253 XP_966567.1 1655 3.9e-181 PREDICTED: ankyrin repeat and zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270012152|gb|EFA08600.1| hypothetical protein TcasGA2_TC006259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZPJ0 627 2.5e-63 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF13606//PF06072//PF00023//PF01553//PF15306 Ankyrin repeat//Alphaherpesvirus tegument protein US9//Ankyrin repeat//Acyltransferase//LIN37 GO:0008152//GO:0007049 metabolic process//cell cycle GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0017053//GO:0019033 transcriptional repressor complex//viral tegument KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.47085 BF_2 111.96 0.69 7118 642916946 XP_008199566.1 487 1.6e-45 PREDICTED: FGFR1 oncogene partner [Tribolium castaneum] 242023379 XM_002432067.1 93 6.49558e-38 Pediculus humanus corporis mitochondrial import inner membrane translocase subunit TIM13, putative, mRNA K17781 TIM13 mitochondrial import inner membrane translocase subunit TIM13 http://www.genome.jp/dbget-bin/www_bget?ko:K17781 Q8AVK1 314 7.4e-27 Mitochondrial import inner membrane translocase subunit Tim13-B OS=Xenopus laevis GN=timm13-b PE=3 SV=1 PF09398//PF16045//PF01468 FOP N terminal dimerisation domain//LisH//GA module GO:0009405//GO:0034453 pathogenesis//microtubule anchoring GO:0005515 protein binding GO:0005815 microtubule organizing center KOG1733 Mitochondrial import inner membrane translocase, subunit TIM13 Cluster-8309.47086 BF_2 89.65 1.37 3018 270015051 EFA11499.1 1436 6.0e-156 hypothetical protein TcasGA2_TC014213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2C3 393 2.2e-36 Beta-1,3-galactosyltransferase 5 OS=Homo sapiens GN=B3GALT5 PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG2287 Galactosyltransferases Cluster-8309.47088 BF_2 3.69 0.42 658 91088697 XP_975033.1 140 2.5e-06 PREDICTED: uncharacterized protein LOC663911 [Tribolium castaneum]>gi|270011669|gb|EFA08117.1| hypothetical protein TcasGA2_TC005721 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.47091 BF_2 76.00 1.17 3016 642921295 XP_008192806.1 1217 1.5e-130 PREDICTED: uncharacterized protein LOC103312850 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47092 BF_2 32.91 0.37 4019 746838318 XP_011049679.1 1504 1.0e-163 PREDICTED: uncharacterized protein LOC105143221 isoform X2 [Acromyrmex echinatior] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 447 1.6e-42 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF07690//PF03137//PF12537 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//The Golgi pH Regulator (GPHR) Family N-terminal GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.47093 BF_2 187.15 1.93 4337 270003958 EFA00406.1 1857 1.3e-204 hypothetical protein TcasGA2_TC003257 [Tribolium castaneum] -- -- -- -- -- K15837 GPSM2 G-protein signaling modulator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15837 P81274 1369 2.1e-149 G-protein-signaling modulator 2 OS=Homo sapiens GN=GPSM2 PE=1 SV=3 PF00515//PF13374//PF13414//PF13176//PF10579//PF07721//PF13181//PF05194 Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//Tetratricopeptide repeat//UreE urease accessory protein, C-terminal domain GO:0019627//GO:0007268//GO:0006461 urea metabolic process//synaptic transmission//protein complex assembly GO:0042802//GO:0033130//GO:0016151//GO:0005515//GO:0043495 identical protein binding//acetylcholine receptor binding//nickel cation binding//protein binding//protein anchor -- -- KOG1130 Predicted G-alpha GTPase interaction protein, contains GoLoco domain Cluster-8309.47098 BF_2 71.88 0.54 5906 642918478 XP_008191493.1 5390 0.0e+00 PREDICTED: epidermal growth factor receptor isoform X1 [Tribolium castaneum] -- -- -- -- -- K04361 EGFR, ERBB1 epidermal growth factor receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04361 P0CY46 4398 0.0e+00 Epidermal growth factor receptor OS=Apis mellifera GN=Egfr PE=2 SV=1 PF00757//PF07714//PF06293//PF00069 Furin-like cysteine rich region//Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468//GO:0007169 protein phosphorylation//transmembrane receptor protein tyrosine kinase signaling pathway GO:0005524//GO:0016773//GO:0004672//GO:0004714 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.47101 BF_2 1049.95 33.15 1612 546682476 ERL92399.1 940 1.0e-98 hypothetical protein D910_09713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 434 2.0e-41 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02402//PF02615 Lysis protein//Malate/L-lactate dehydrogenase GO:0055114//GO:0008152//GO:0009405//GO:0019835 oxidation-reduction process//metabolic process//pathogenesis//cytolysis GO:0016491 oxidoreductase activity GO:0019867 outer membrane -- -- Cluster-8309.47102 BF_2 461.63 4.80 4311 478257975 ENN78113.1 1145 4.8e-122 hypothetical protein YQE_05267, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V0D5 602 1.8e-60 Malate dehydrogenase OS=Pyrococcus abyssi (strain GE5 / Orsay) GN=mdh PE=3 SV=1 PF02615 Malate/L-lactate dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.47105 BF_2 207.45 1.42 6414 546682476 ERL92399.1 637 5.7e-63 hypothetical protein D910_09713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q58820 329 1.2e-28 L-sulfolactate dehydrogenase OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=comC PE=1 SV=1 PF02615//PF08289 Malate/L-lactate dehydrogenase//Influenza Matrix protein (M1) C-terminal domain GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0003723//GO:0016491//GO:0005198 RNA binding//oxidoreductase activity//structural molecule activity -- -- -- -- Cluster-8309.47106 BF_2 47.07 0.84 2640 270017024 EFA13470.1 982 2.3e-103 hypothetical protein TcasGA2_TC001911 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 300 1.2e-25 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.47107 BF_2 81.93 1.36 2813 270017024 EFA13470.1 983 1.9e-103 hypothetical protein TcasGA2_TC001911 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 300 1.2e-25 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.47109 BF_2 60.10 6.85 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47111 BF_2 249.01 5.43 2204 741829289 AJA91071.1 1471 3.8e-160 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 1073 2.2e-115 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.47113 BF_2 317.42 2.45 5708 642912871 XP_008201290.1 4729 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X7 [Tribolium castaneum] 642912874 XM_008203070.1 1284 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X9, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1804 9.9e-200 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00609//PF00130//PF00788//PF00781//PF00076//PF00628//PF07649 Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Ras association (RalGDS/AF-6) domain//Diacylglycerol kinase catalytic domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//PHD-finger//C1-like domain GO:0035556//GO:0055114//GO:0046486//GO:0007165//GO:0009395//GO:0007205 intracellular signal transduction//oxidation-reduction process//glycerolipid metabolic process//signal transduction//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway GO:0003676//GO:0016301//GO:0047134//GO:0004143//GO:0005515 nucleic acid binding//kinase activity//protein-disulfide reductase activity//diacylglycerol kinase activity//protein binding -- -- KOG1169 Diacylglycerol kinase Cluster-8309.47116 BF_2 82.77 0.57 6330 270010053 EFA06501.1 2365 2.4e-263 hypothetical protein TcasGA2_TC009400 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 957 1.8e-101 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF00665//PF05225//PF00098 Integrase core domain//helix-turn-helix, Psq domain//Zinc knuckle GO:0015074 DNA integration GO:0008270//GO:0003677//GO:0003676 zinc ion binding//DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.47117 BF_2 130.89 0.80 7141 270010053 EFA06501.1 2365 2.7e-263 hypothetical protein TcasGA2_TC009400 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT39 957 2.0e-101 Transposon Tf2-6 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-6 PE=3 SV=1 PF05225//PF00098//PF00665 helix-turn-helix, Psq domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0008270//GO:0003676//GO:0003677 zinc ion binding//nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.47119 BF_2 333.98 2.21 6617 189239223 XP_973572.2 678 1.0e-67 PREDICTED: DAZ-associated protein 2 isoform X1 [Tribolium castaneum] 642928676 XM_008201511.1 159 1.23467e-74 PREDICTED: Tribolium castaneum DAZ-associated protein 2 (LOC662381), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF05115 Cytochrome B6-F complex subunit VI (PetL) GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.47120 BF_2 427.09 7.58 2644 189240891 XP_971710.2 3065 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Bre1 [Tribolium castaneum]>gi|270013497|gb|EFA09945.1| hypothetical protein TcasGA2_TC012098 [Tribolium castaneum] 195552621 XM_002076477.1 132 5.00368e-60 Drosophila simulans GD17597 (Dsim\GD17597), mRNA K10696 BRE1 E3 ubiquitin-protein ligase BRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10696 Q9VRP9 2307 2.2e-258 E3 ubiquitin-protein ligase Bre1 OS=Drosophila melanogaster GN=Bre1 PE=1 SV=2 PF17078//PF16331//PF04111//PF04739//PF07926//PF04632 SWI5-dependent HO expression protein 3//TolA binding protein trimerisation//Autophagy protein Apg6//5'-AMP-activated protein kinase beta subunit, interaction domain//TPR/MLP1/MLP2-like protein//Fusaric acid resistance protein family GO:0048309//GO:0006810//GO:0070206//GO:0006914//GO:0051028//GO:0006606 endoplasmic reticulum inheritance//transport//protein trimerization//autophagy//mRNA transport//protein import into nucleus GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding GO:0005886 plasma membrane KOG0978 E3 ubiquitin ligase involved in syntaxin degradation Cluster-8309.47121 BF_2 157.00 10.97 886 189240891 XP_971710.2 1244 3.2e-134 PREDICTED: E3 ubiquitin-protein ligase Bre1 [Tribolium castaneum]>gi|270013497|gb|EFA09945.1| hypothetical protein TcasGA2_TC012098 [Tribolium castaneum] 642934616 XM_966617.3 360 0 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase Bre1 (LOC660381), mRNA K10696 BRE1 E3 ubiquitin-protein ligase BRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K10696 Q9VRP9 1145 4.0e-124 E3 ubiquitin-protein ligase Bre1 OS=Drosophila melanogaster GN=Bre1 PE=1 SV=2 PF13639//PF14634//PF12861//PF12678//PF00097 Ring finger domain//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0978 E3 ubiquitin ligase involved in syntaxin degradation Cluster-8309.47123 BF_2 11.00 0.89 804 514683686 XP_004989424.1 163 6.5e-09 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF04988//PF02150 Zinc-finger double domain//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003677//GO:0003899 metal ion binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.47124 BF_2 484.27 5.75 3808 91079074 XP_975225.1 1006 5.5e-106 PREDICTED: ras-related protein Rab-10 [Tribolium castaneum]>gi|270003655|gb|EFA00103.1| hypothetical protein TcasGA2_TC002919 [Tribolium castaneum] 642916371 XM_970132.3 262 3.91425e-132 PREDICTED: Tribolium castaneum ras-related protein Rab-10 (LOC664117), mRNA K07903 RAB10 Ras-related protein Rab-10 http://www.genome.jp/dbget-bin/www_bget?ko:K07903 P22127 812 7.1e-85 Ras-related protein Rab-10 OS=Diplobatis ommata PE=2 SV=1 PF01926//PF04344//PF08477//PF03193//PF00025//PF04670//PF00071 50S ribosome-binding GTPase//Chemotaxis phosphatase, CheZ//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//Ras family GO:0050920//GO:0007264//GO:0015031 regulation of chemotaxis//small GTPase mediated signal transduction//protein transport GO:0003824//GO:0005525//GO:0003924 catalytic activity//GTP binding//GTPase activity GO:0009288 bacterial-type flagellum KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.47125 BF_2 923.23 2.60 15152 826444743 XP_012531039.1 5876 0.0e+00 PREDICTED: voltage-dependent calcium channel type A subunit alpha-1 isoform X7 [Monomorium pharaonis] 259906454 NM_001165911.1 940 0 Tribolium castaneum cacophony A (Cac), mRNA >gnl|BL_ORD_ID|7385018 Tribolium castaneum cacophony A (CAC) mRNA, complete cds -- -- -- -- C9D7C2 3178 0.0e+00 Voltage-dependent calcium channel type A subunit alpha-1 OS=Apis mellifera GN=CAC PE=2 SV=1 PF00230//PF14138//PF13405//PF00036//PF02561//PF01635//PF00520 Major intrinsic protein//Cytochrome c oxidase assembly protein COX16//EF-hand domain//EF hand//Flagellar protein FliS//Coronavirus M matrix/glycoprotein//Ion transport protein GO:0019058//GO:0006810//GO:0055085//GO:0006811 viral life cycle//transport//transmembrane transport//ion transport GO:0005215//GO:0005509//GO:0005216 transporter activity//calcium ion binding//ion channel activity GO:0031966//GO:0009288//GO:0016020 mitochondrial membrane//bacterial-type flagellum//membrane KOG2301 Voltage-gated Ca2+ channels, alpha1 subunits Cluster-8309.47127 BF_2 429.75 15.29 1463 91079142 XP_975469.1 1492 9.3e-163 PREDICTED: hypoxia-inducible factor 1-alpha inhibitor [Tribolium castaneum]>gi|270004836|gb|EFA01284.1| hypoxia-inducible factor 1, alpha subunit inhibitor [Tribolium castaneum] -- -- -- -- -- K18055 HIF1AN hypoxia-inducible factor 1-alpha inhibitor (HIF hydroxylase) http://www.genome.jp/dbget-bin/www_bget?ko:K18055 Q9NWT6 1105 2.9e-119 Hypoxia-inducible factor 1-alpha inhibitor OS=Homo sapiens GN=HIF1AN PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.47135 BF_2 109.53 0.54 8723 642926595 XP_008194933.1 1180 8.4e-126 PREDICTED: fasciclin-3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15278 504 8.4e-49 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF13895//PF02017//PF09230 Immunoglobulin domain//CIDE-N domain//DNA fragmentation factor 40 kDa GO:0006915//GO:0006309 apoptotic process//apoptotic DNA fragmentation GO:0016787//GO:0005515 hydrolase activity//protein binding GO:0005622//GO:0005634//GO:0005737 intracellular//nucleus//cytoplasm -- -- Cluster-8309.47136 BF_2 22.04 3.76 532 642926597 XP_008194934.1 255 9.3e-20 PREDICTED: fasciclin-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47137 BF_2 872.00 4.41 8555 642926595 XP_008194933.1 1393 1.7e-150 PREDICTED: fasciclin-3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15278 540 5.5e-53 Fasciclin-3 OS=Drosophila melanogaster GN=Fas3 PE=2 SV=1 PF02017//PF13895//PF13965//PF12539//PF09230 CIDE-N domain//Immunoglobulin domain//dsRNA-gated channel SID-1//Chromosome segregation protein Csm1/Pcs1//DNA fragmentation factor 40 kDa GO:0006915//GO:0033227//GO:0015931//GO:0006309 apoptotic process//dsRNA transport//nucleobase-containing compound transport//apoptotic DNA fragmentation GO:0051033//GO:0016787//GO:0005515 RNA transmembrane transporter activity//hydrolase activity//protein binding GO:0005622//GO:0005737//GO:0016021//GO:0005634 intracellular//cytoplasm//integral component of membrane//nucleus -- -- Cluster-8309.47138 BF_2 40.73 4.55 662 642937521 XP_008199080.1 240 6.4e-18 PREDICTED: heterogeneous nuclear ribonucleoprotein 27C isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04140 Isoprenylcysteine carboxyl methyltransferase (ICMT) family GO:0006479//GO:0006481 protein methylation//C-terminal protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47139 BF_2 117.00 4.70 1329 189237653 XP_001811993.1 884 2.7e-92 PREDICTED: rab-like protein 3 [Tribolium castaneum]>gi|270006864|gb|EFA03312.1| hypothetical protein TcasGA2_TC013254 [Tribolium castaneum] -- -- -- -- -- K07933 RABL3 Rab-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07933 Q5ZKR4 554 2.0e-55 Rab-like protein 3 OS=Gallus gallus GN=RABL3 PE=2 SV=1 PF08477//PF05049//PF01926//PF00004//PF00025//PF03193//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//Interferon-inducible GTPase (IIGP)//50S ribosome-binding GTPase//ATPase family associated with various cellular activities (AAA)//ADP-ribosylation factor family//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity GO:0016020 membrane -- -- Cluster-8309.47140 BF_2 28.08 0.55 2437 270010707 EFA07155.1 1428 4.1e-155 hypothetical protein TcasGA2_TC010149 [Tribolium castaneum] 642930305 XM_008198117.1 521 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04957 HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04957 Q9TV66 708 5.2e-73 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 OS=Oryctolagus cuniculus GN=HCN4 PE=2 SV=1 PF02962 5-carboxymethyl-2-hydroxymuconate isomerase GO:0006570//GO:0019439//GO:0018874 tyrosine metabolic process//aromatic compound catabolic process//benzoate metabolic process GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity -- -- -- -- Cluster-8309.47142 BF_2 33.00 0.81 1985 91077256 XP_974061.1 862 1.4e-89 PREDICTED: trypsin-1 [Tribolium castaneum]>gi|270002769|gb|EEZ99216.1| serine protease-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 238 1.3e-18 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF04928//PF01008//PF00089 Poly(A) polymerase central domain//Initiation factor 2 subunit family//Trypsin GO:0006508//GO:0043631//GO:0044237 proteolysis//RNA polyadenylation//cellular metabolic process GO:0004652//GO:0004252//GO:0008233 polynucleotide adenylyltransferase activity//serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.47144 BF_2 437.22 7.35 2774 642923285 XP_008193690.1 2418 7.5e-270 PREDICTED: venom dipeptidyl peptidase 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B1A4F7 1320 6.4e-144 Venom dipeptidyl peptidase 4 OS=Vespula vulgaris PE=1 SV=1 PF00930//PF02129//PF00326 Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family)//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.47146 BF_2 32.00 1.39 1250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47147 BF_2 25.47 0.38 3105 91078388 XP_974322.1 1200 1.4e-128 PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|642915363|ref|XP_008190586.1| PREDICTED: carbonic anhydrase 1 [Tribolium castaneum]>gi|270003984|gb|EFA00432.1| hypothetical protein TcasGA2_TC003286 [Tribolium castaneum] -- -- -- -- -- K01672 E4.2.1.1 carbonic anhydrase http://www.genome.jp/dbget-bin/www_bget?ko:K01672 Q92051 566 1.9e-56 Carbonic anhydrase OS=Danio rerio GN=cahz PE=1 SV=2 -- -- GO:0006730//GO:0006807 one-carbon metabolic process//nitrogen compound metabolic process GO:0008270//GO:0004089//GO:0046872 zinc ion binding//carbonate dehydratase activity//metal ion binding -- -- -- -- Cluster-8309.47149 BF_2 2.00 0.31 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47154 BF_2 231.42 1.31 7692 642936873 XP_969385.2 1572 2.6e-171 PREDICTED: cdc42-interacting protein 4 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RU3 725 1.8e-74 Formin-binding protein 1 OS=Homo sapiens GN=FNBP1 PE=1 SV=2 PF00018//PF14604//PF02185//PF09177//PF00816 SH3 domain//Variant SH3 domain//Hr1 repeat//Syntaxin 6, N-terminal//H-NS histone family GO:0007165//GO:0006355//GO:0048193 signal transduction//regulation of transcription, DNA-templated//Golgi vesicle transport GO:0003677//GO:0005515 DNA binding//protein binding GO:0005622//GO:0016020 intracellular//membrane KOG3565 Cdc42-interacting protein CIP4 Cluster-8309.47155 BF_2 351.01 5.68 2872 478257994 ENN78132.1 1444 6.7e-157 hypothetical protein YQE_05286, partial [Dendroctonus ponderosae] 815908496 XM_003488754.2 48 2.69605e-13 PREDICTED: Bombus impatiens protein SEC13 homolog (LOC100746611), mRNA K14004 SEC13 protein transport protein SEC13 http://www.genome.jp/dbget-bin/www_bget?ko:K14004 Q9D1M0 1099 2.8e-118 Protein SEC13 homolog OS=Mus musculus GN=Sec13 PE=2 SV=3 PF13606//PF16473//PF00023//PF00400 Ankyrin repeat//Domain of unknown function (DUF5051)//Ankyrin repeat//WD domain, G-beta repeat -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- KOG1332 Vesicle coat complex COPII, subunit SEC13 Cluster-8309.47156 BF_2 237.01 5.36 2138 91078830 XP_971270.1 1311 1.3e-141 PREDICTED: metallophosphoesterase domain-containing protein 1 [Tribolium castaneum]>gi|270004125|gb|EFA00573.1| hypothetical protein TcasGA2_TC003443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q22306 692 3.3e-71 UPF0046 protein T07D4.2 OS=Caenorhabditis elegans GN=T07D4.2 PE=1 SV=3 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3947 Phosphoesterases Cluster-8309.47159 BF_2 852.25 7.78 4867 642934675 XP_008197763.1 4351 0.0e+00 PREDICTED: Ca(2+)/calmodulin-responsive adenylate cyclase isoform X2 [Tribolium castaneum] 642934684 XM_008199547.1 110 1.57199e-47 PREDICTED: Tribolium castaneum Ca(2+)/calmodulin-responsive adenylate cyclase (LOC661438), transcript variant X7, mRNA K08041 ADCY1 adenylate cyclase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08041 P32870 1576 2.3e-173 Ca(2+)/calmodulin-responsive adenylate cyclase OS=Drosophila melanogaster GN=rut PE=1 SV=2 PF02542//PF00211 YgbB family//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0016114 cyclic nucleotide biosynthetic process//intracellular signal transduction//terpenoid biosynthetic process GO:0016849//GO:0008685 phosphorus-oxygen lyase activity//2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity -- -- -- -- Cluster-8309.47160 BF_2 618.37 11.21 2594 189242404 XP_968940.2 2817 0.0e+00 PREDICTED: palmitoyltransferase ZDHHC5 isoform X2 [Tribolium castaneum] 642939045 XM_963847.3 577 0 PREDICTED: Tribolium castaneum palmitoyltransferase ZDHHC5 (LOC657384), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q2THW9 732 9.1e-76 Palmitoyltransferase ZDHHC5 OS=Canis familiaris GN=ZDHHC5 PE=2 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270 zinc ion binding -- -- KOG1311 DHHC-type Zn-finger proteins Cluster-8309.47161 BF_2 176.07 0.97 7898 270016265 EFA12711.1 933 3.3e-97 hypothetical protein TcasGA2_TC002345 [Tribolium castaneum] 642939045 XM_963847.3 205 3.95862e-100 PREDICTED: Tribolium castaneum palmitoyltransferase ZDHHC5 (LOC657384), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47165 BF_2 259.25 9.59 1418 642932331 XP_008197068.1 440 8.8e-41 PREDICTED: uncharacterized protein LOC103314051 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07947//PF00335//PF01284//PF06624//PF03348 YhhN-like protein//Tetraspanin family//Membrane-associating domain//Ribosome associated membrane protein RAMP4//Serine incorporator (Serinc) -- -- -- -- GO:0016021//GO:0016020//GO:0005783 integral component of membrane//membrane//endoplasmic reticulum -- -- Cluster-8309.47169 BF_2 225.72 3.82 2762 642926303 XP_008194869.1 919 4.9e-96 PREDICTED: GDNF-inducible zinc finger protein 1-like [Tribolium castaneum]>gi|270008503|gb|EFA04951.1| hypothetical protein TcasGA2_TC015019 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJU3 323 2.6e-28 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF09008//PF00096//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Head binding//Zinc finger, C2H2 type//Zinc-finger double domain GO:0009405 pathogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47176 BF_2 231.69 2.88 3648 546674893 ERL86179.1 3056 0.0e+00 hypothetical protein D910_03592, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 1.08733e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1896 1.4e-210 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.47177 BF_2 74.47 1.26 2757 91090486 XP_968848.1 975 1.6e-102 PREDICTED: GTP-binding protein Di-Ras2 [Tribolium castaneum]>gi|270013863|gb|EFA10311.1| hypothetical protein TcasGA2_TC012527 [Tribolium castaneum] 642935350 XM_963755.2 98 4.14862e-41 PREDICTED: Tribolium castaneum GTP-binding protein Di-Ras2 (LOC657287), mRNA K07841 DIRAS2 DIRAS family, GTP-binding Ras-like 2 http://www.genome.jp/dbget-bin/www_bget?ko:K07841 Q95KD9 747 1.8e-77 GTP-binding protein Di-Ras2 OS=Macaca fascicularis GN=DIRAS2 PE=2 SV=1 PF08477//PF03193//PF01926//PF01637//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase//Archaeal ATPase//Ras family//ADP-ribosylation factor family GO:0007264//GO:0006184 small GTPase mediated signal transduction//obsolete GTP catabolic process GO:0003924//GO:0005525//GO:0005524 GTPase activity//GTP binding//ATP binding GO:0016020 membrane KOG0395 Ras-related GTPase Cluster-8309.47178 BF_2 134.00 3.66 1818 91082227 XP_972577.1 1114 7.9e-119 PREDICTED: probable cytochrome P450 4d14 [Tribolium castaneum]>gi|270008181|gb|EFA04629.1| cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q5RCN6 802 4.9e-84 Cytochrome P450 4V2 OS=Pongo abelii GN=CYP4V2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005488//GO:0016705//GO:0005506//GO:0016491//GO:0020037 binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity//heme binding -- -- -- -- Cluster-8309.4718 BF_2 7.00 0.43 967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47180 BF_2 1.00 15.80 222 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47183 BF_2 51.91 0.59 3951 189238946 XP_972230.2 195 6.3e-12 PREDICTED: orexin receptor type 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.47184 BF_2 82.00 1.37 2794 826469534 XP_012535839.1 912 3.2e-95 PREDICTED: uncharacterized protein LOC105836387 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47186 BF_2 597.59 6.63 4058 642931121 XP_008201670.1 421 4.0e-38 PREDICTED: autism susceptibility gene 2 protein isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04617//PF08597 Hox9 activation region//Translation initiation factor eIF3 subunit GO:0006351//GO:0006446 transcription, DNA-templated//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840//GO:0005634//GO:0005737//GO:0005852 ribosome//nucleus//cytoplasm//eukaryotic translation initiation factor 3 complex -- -- Cluster-8309.47189 BF_2 754.91 6.47 5166 642931695 XP_008196691.1 301 4.2e-24 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O55035 139 1.1e-06 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF05324 Sperm antigen HE2 -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.47190 BF_2 480.57 8.09 2773 642910843 XP_008193432.1 1665 1.5e-182 PREDICTED: xaa-Pro dipeptidase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14213 PEPD Xaa-Pro dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K14213 P12955 1250 8.4e-136 Xaa-Pro dipeptidase OS=Homo sapiens GN=PEPD PE=1 SV=3 PF05195 Aminopeptidase P, N-terminal domain -- -- GO:0030145//GO:0004177 manganese ion binding//aminopeptidase activity -- -- KOG2737 Putative metallopeptidase Cluster-8309.47192 BF_2 34.02 0.31 4911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47195 BF_2 185.92 1.33 6157 642912869 XP_008201289.1 4842 0.0e+00 PREDICTED: diacylglycerol kinase theta isoform X6 [Tribolium castaneum] 642912868 XM_008203067.1 1425 0 PREDICTED: Tribolium castaneum diacylglycerol kinase theta (LOC659765), transcript variant X6, mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q6P5E8 1296 8.6e-141 Diacylglycerol kinase theta OS=Mus musculus GN=Dgkq PE=2 SV=1 PF00076//PF00781//PF00130//PF00609//PF00788//PF00628//PF07649 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Diacylglycerol kinase catalytic domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Diacylglycerol kinase accessory domain//Ras association (RalGDS/AF-6) domain//PHD-finger//C1-like domain GO:0007165//GO:0009395//GO:0007205//GO:0055114//GO:0035556//GO:0046486 signal transduction//phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//oxidation-reduction process//intracellular signal transduction//glycerolipid metabolic process GO:0004143//GO:0005515//GO:0016301//GO:0003676//GO:0047134 diacylglycerol kinase activity//protein binding//kinase activity//nucleic acid binding//protein-disulfide reductase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.47198 BF_2 462.40 3.24 6250 478257502 ENN77658.1 2692 2.8e-301 hypothetical protein YQE_05952, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q13439 325 3.4e-28 Golgin subfamily A member 4 OS=Homo sapiens GN=GOLGA4 PE=1 SV=1 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.4720 BF_2 16.65 0.63 1384 332373478 AEE61880.1 609 2.2e-60 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 415 2.8e-39 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04265//PF04263 Thiamin pyrophosphokinase, vitamin B1 binding domain//Thiamin pyrophosphokinase, catalytic domain GO:0009229//GO:0006772 thiamine diphosphate biosynthetic process//thiamine metabolic process GO:0005524//GO:0030975//GO:0004788 ATP binding//thiamine binding//thiamine diphosphokinase activity -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.47201 BF_2 604.65 2.20 11799 642930533 XP_008196445.1 4961 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 642930532 XM_008198223.1 980 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X12, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 4167 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47203 BF_2 822.26 2.44 14410 642930533 XP_008196445.1 4913 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 isoform X12 [Tribolium castaneum] 642930520 XM_008198217.1 960 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X6, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 4184 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47204 BF_2 93.59 0.61 6657 642930525 XP_008196441.1 3418 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X8 [Tribolium castaneum] 795051011 XM_012014668.1 258 1.14918e-129 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X22, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 1840 7.8e-204 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47207 BF_2 109.41 0.32 14429 642930521 XP_008196439.1 3729 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X6 [Tribolium castaneum] 642930520 XM_008198217.1 806 0 PREDICTED: Tribolium castaneum inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC663934), transcript variant X6, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 3317 0.0e+00 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47209 BF_2 388.35 2.42 7000 642930523 XP_008196440.1 2319 5.7e-258 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X7 [Tribolium castaneum] 795051011 XM_012014668.1 258 1.20872e-129 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X22, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 1837 1.8e-203 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328//PF17076 Histidine phosphatase superfamily (branch 2)//SBE2, cell-qall formation GO:0006771//GO:0019497//GO:0031505 riboflavin metabolic process//hexachlorocyclohexane metabolic process//fungal-type cell wall organization GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47210 BF_2 410.33 2.68 6699 642930525 XP_008196441.1 3404 0.0e+00 PREDICTED: inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase isoform X8 [Tribolium castaneum] 795051011 XM_012014668.1 258 1.15647e-129 PREDICTED: Vollenhovia emeryi inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 (LOC105563237), transcript variant X22, mRNA K13024 PPIP5K, VIP inositol-hexakisphosphate/diphosphoinositol-pentakisphosphate 1-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K13024 Q9VR59 1841 6.0e-204 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase OS=Drosophila melanogaster GN=l(1)G0196 PE=1 SV=2 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG1057 Arp2/3 complex-interacting protein VIP1/Asp1, involved in regulation of actin cytoskeleton Cluster-8309.47211 BF_2 29.87 1.44 1157 91089445 XP_966341.1 348 3.3e-30 PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|91089447|ref|XP_975797.1| PREDICTED: rho GDP-dissociation inhibitor 2 [Tribolium castaneum]>gi|270012573|gb|EFA09021.1| hypothetical protein TcasGA2_TC006730 [Tribolium castaneum] -- -- -- -- -- K12462 ARHGDI, RHOGDI Rho GDP-dissociation inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K12462 P52565 234 2.3e-18 Rho GDP-dissociation inhibitor 1 OS=Homo sapiens GN=ARHGDIA PE=1 SV=3 PF02115 RHO protein GDP dissociation inhibitor -- -- GO:0005094 Rho GDP-dissociation inhibitor activity GO:0005737 cytoplasm KOG3205 Rho GDP-dissociation inhibitor Cluster-8309.47214 BF_2 38.32 0.31 5541 642940052 XP_008200969.1 2913 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF07724//PF00004//PF00439//PF05496//PF06068//PF01695//PF07728//PF00910//PF04851//PF00005 AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//Bromodomain//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//RNA helicase//Type III restriction enzyme, res subunit//ABC transporter GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0003724//GO:0009378//GO:0016887//GO:0005515//GO:0003723//GO:0003678//GO:0005524//GO:0003677//GO:0016787 RNA helicase activity//four-way junction helicase activity//ATPase activity//protein binding//RNA binding//DNA helicase activity//ATP binding//DNA binding//hydrolase activity GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.47215 BF_2 85.43 1.31 3020 642915313 XP_008190567.1 1625 7.3e-178 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 766920220 XM_011506269.1 107 4.51753e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1210 4.0e-131 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF00437//PF00270//PF03060//PF03368 Type II/IV secretion system protein//DEAD/DEAH box helicase//Nitronate monooxygenase//Dicer dimerisation domain GO:0006810//GO:0051252//GO:0055114//GO:0006807 transport//regulation of RNA metabolic process//oxidation-reduction process//nitrogen compound metabolic process GO:0018580//GO:0005524//GO:0016891//GO:0003676 nitronate monooxygenase activity//ATP binding//endoribonuclease activity, producing 5'-phosphomonoesters//nucleic acid binding -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.47216 BF_2 144.18 2.26 2961 642915313 XP_008190567.1 1620 2.7e-177 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 766920220 XM_011506269.1 107 4.42821e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1205 1.5e-130 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF03060//PF00270//PF00437//PF03368 Nitronate monooxygenase//DEAD/DEAH box helicase//Type II/IV secretion system protein//Dicer dimerisation domain GO:0006810//GO:0051252//GO:0006807//GO:0055114 transport//regulation of RNA metabolic process//nitrogen compound metabolic process//oxidation-reduction process GO:0005524//GO:0018580//GO:0003676//GO:0016891 ATP binding//nitronate monooxygenase activity//nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.47218 BF_2 533.57 5.98 4019 642923221 XP_008193661.1 1362 3.0e-147 PREDICTED: uncharacterized protein LOC103313092 [Tribolium castaneum] -- -- -- -- -- K18269 PDCD10 programmed cell death protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K18269 Q8AVR4 477 5.2e-46 Programmed cell death protein 10 OS=Xenopus laevis GN=pdcd10 PE=2 SV=1 PF00669//PF00863//PF09815 Bacterial flagellin N-terminal helical region//Peptidase family C4//XK-related protein GO:0006508//GO:0071973 proteolysis//bacterial-type flagellum-dependent cell motility GO:0008234//GO:0005198 cysteine-type peptidase activity//structural molecule activity GO:0016021 integral component of membrane KOG4025 Putative apoptosis related protein Cluster-8309.47220 BF_2 56.61 0.36 6953 91077500 XP_969314.1 3473 0.0e+00 PREDICTED: exocyst complex component 1 [Tribolium castaneum]>gi|270002145|gb|EEZ98592.1| hypothetical protein TcasGA2_TC001107 [Tribolium castaneum] 805812953 XM_012292417.1 89 1.06161e-35 PREDICTED: Megachile rotundata exocyst complex component 1 (LOC100878684), transcript variant X4, mRNA -- -- -- -- Q9VVG4 2093 3.7e-233 Exocyst complex component 1 OS=Drosophila melanogaster GN=sec3 PE=1 SV=2 PF00588//PF07544 SpoU rRNA Methylase family//RNA polymerase II transcription mediator complex subunit 9 GO:0006396//GO:0009451//GO:0006357 RNA processing//RNA modification//regulation of transcription from RNA polymerase II promoter GO:0008173//GO:0001104//GO:0003723 RNA methyltransferase activity//RNA polymerase II transcription cofactor activity//RNA binding GO:0016592 mediator complex KOG2148 Exocyst protein Sec3 Cluster-8309.47222 BF_2 64.91 1.08 2790 270006157 EFA02605.1 2133 8.4e-237 hypothetical protein TcasGA2_TC008324 [Tribolium castaneum] 332375782 BT128071.1 218 8.23202e-108 Dendroctonus ponderosae clone DPO116_B20 unknown mRNA K01892 HARS, hisS histidyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01892 Q61035 1637 1.1e-180 Histidine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Hars PE=2 SV=2 PF00458//PF00587//PF00152 WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG1936 Histidyl-tRNA synthetase Cluster-8309.47223 BF_2 872.63 6.67 5758 270012867 EFA09315.1 1048 1.1e-110 hypothetical protein TcasGA2_TC030748 [Tribolium castaneum] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 532 3.2e-52 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 PF08288//PF07830//PF04420 PIGA (GPI anchor biosynthesis)//Protein serine/threonine phosphatase 2C, C-terminal domain//CHD5-like protein GO:0006470//GO:0006506//GO:0071816 protein dephosphorylation//GPI anchor biosynthetic process//tail-anchored membrane protein insertion into ER membrane GO:0000287//GO:0004721//GO:0030145 magnesium ion binding//phosphoprotein phosphatase activity//manganese ion binding -- -- KOG2687 Spindle pole body protein, contains UNC-84 domain Cluster-8309.47227 BF_2 405.90 26.33 932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47229 BF_2 33.00 3.06 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47231 BF_2 318.47 7.86 1982 91080597 XP_973963.1 1525 1.9e-166 PREDICTED: vacuolar protein-sorting-associated protein 36 [Tribolium castaneum]>gi|270005813|gb|EFA02261.1| hypothetical protein TcasGA2_TC007925 [Tribolium castaneum] -- -- -- -- -- K12190 VPS36, EAP45 ESCRT-II complex subunit VPS36 http://www.genome.jp/dbget-bin/www_bget?ko:K12190 Q9VU87 1000 5.9e-107 Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2 PF11605 Vacuolar protein sorting protein 36 Vps36 -- -- GO:0032266//GO:0043130 phosphatidylinositol-3-phosphate binding//ubiquitin binding -- -- KOG2760 Vacuolar sorting protein VPS36 Cluster-8309.47232 BF_2 63.00 3.37 1069 675386912 KFM79809.1 1024 1.3e-108 Cathepsin L, partial [Stegodyphus mimosarum] 530733 X80989.1 58 2.7181e-19 N.norvegicus mRNA for cathepsin L K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 843 5.0e-89 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.47234 BF_2 344.72 3.95 3942 91083301 XP_974629.1 1378 4.2e-149 PREDICTED: alpha-methylacyl-CoA racemase [Tribolium castaneum]>gi|270007738|gb|EFA04186.1| hypothetical protein TcasGA2_TC014435 [Tribolium castaneum] -- -- -- -- -- K01796 E5.1.99.4, AMACR, mcr alpha-methylacyl-CoA racemase http://www.genome.jp/dbget-bin/www_bget?ko:K01796 O09174 1099 3.9e-118 Alpha-methylacyl-CoA racemase OS=Mus musculus GN=Amacr PE=1 SV=4 PF02515//PF04178//PF07647//PF00536 CoA-transferase family III//Got1/Sft2-like family//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0008152//GO:0016192 metabolic process//vesicle-mediated transport GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.47235 BF_2 25.00 0.71 1757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47237 BF_2 64.02 1.21 2501 642934019 XP_008197606.1 667 7.4e-67 PREDICTED: PCTP-like protein isoform X1 [Tribolium castaneum] 642934018 XM_008199384.1 142 1.30569e-65 PREDICTED: Tribolium castaneum phosphatidylcholine transfer protein (LOC662808), transcript variant X1, mRNA -- -- -- -- Q9Y365 309 9.9e-27 PCTP-like protein OS=Homo sapiens GN=STARD10 PE=1 SV=2 PF12592//PF01852 Protein of unknown function (DUF3763)//START domain -- -- GO:0016820//GO:0008289 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//lipid binding -- -- KOG2761 START domain-containing proteins involved in steroidogenesis/phosphatidylcholine transfer Cluster-8309.47238 BF_2 749.24 13.19 2664 91080563 XP_973259.1 2637 2.9e-295 PREDICTED: alpha-N-acetylglucosaminidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 1665 6.1e-184 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.47239 BF_2 62.22 0.64 4349 91093228 XP_967462.1 705 5.0e-71 PREDICTED: phosphopantothenoylcysteine decarboxylase [Tribolium castaneum]>gi|270016594|gb|EFA13040.1| hypothetical protein TcasGA2_TC010571 [Tribolium castaneum] -- -- -- -- -- K01598 PPCDC, coaC phosphopantothenoylcysteine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01598 Q8BZB2 574 3.2e-57 Phosphopantothenoylcysteine decarboxylase OS=Mus musculus GN=Ppcdc PE=2 SV=1 PF02297//PF08070//PF02569//PF05676//PF02441 Cytochrome oxidase c subunit VIb//DTHCT (NUC029) region//Pantoate-beta-alanine ligase//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7)//Flavoprotein GO:0008152//GO:0006744//GO:0006123//GO:0006120//GO:0015940//GO:0006118//GO:0006814//GO:0015992//GO:0019482//GO:0006265 metabolic process//ubiquinone biosynthetic process//mitochondrial electron transport, cytochrome c to oxygen//mitochondrial electron transport, NADH to ubiquinone//pantothenate biosynthetic process//obsolete electron transport//sodium ion transport//proton transport//beta-alanine metabolic process//DNA topological change GO:0003824//GO:0003677//GO:0003954//GO:0003918//GO:0004592//GO:0004129//GO:0005524//GO:0008137 catalytic activity//DNA binding//NADH dehydrogenase activity//DNA topoisomerase type II (ATP-hydrolyzing) activity//pantoate-beta-alanine ligase activity//cytochrome-c oxidase activity//ATP binding//NADH dehydrogenase (ubiquinone) activity GO:0005634//GO:0045277//GO:0005739 nucleus//respiratory chain complex IV//mitochondrion KOG0672 Halotolerance protein HAL3 (contains flavoprotein domain) Cluster-8309.47242 BF_2 240.50 2.85 3811 642934319 XP_008198599.1 1520 1.4e-165 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] 831504568 XM_012856442.1 55 4.60957e-17 PREDICTED: Fundulus heteroclitus inositol hexakisphosphate kinase 1 (ip6k1), mRNA K07756 IP6K, IHPK inositol-hexakisphosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07756 Q96PC2 434 4.8e-41 Inositol hexakisphosphate kinase 3 OS=Homo sapiens GN=IP6K3 PE=1 SV=2 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1620 Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex Cluster-8309.47244 BF_2 145.67 5.64 1367 642934319 XP_008198599.1 370 1.1e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47245 BF_2 121.27 2.12 2685 189240781 XP_969579.2 1527 1.5e-166 PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum]>gi|642934322|ref|XP_008198600.1| PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum] 831504568 XM_012856442.1 55 3.23463e-17 PREDICTED: Fundulus heteroclitus inositol hexakisphosphate kinase 1 (ip6k1), mRNA K07756 IP6K, IHPK inositol-hexakisphosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07756 Q96PC2 434 3.4e-41 Inositol hexakisphosphate kinase 3 OS=Homo sapiens GN=IP6K3 PE=1 SV=2 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1620 Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex Cluster-8309.47247 BF_2 39.00 1.56 1335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47249 BF_2 72.74 1.08 3108 642932487 XP_008197135.1 1919 6.1e-212 PREDICTED: E3 ubiquitin-protein ligase RBBP6 [Tribolium castaneum] -- -- -- -- -- K10624 RBBP6 E3 ubiquitin-protein ligase RBBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K10624 Q7Z6E9 787 4.6e-82 E3 ubiquitin-protein ligase RBBP6 OS=Homo sapiens GN=RBBP6 PE=1 SV=1 PF00097//PF00098//PF04564//PF14634//PF13639//PF08783 Zinc finger, C3HC4 type (RING finger)//Zinc knuckle//U-box domain//zinc-RING finger domain//Ring finger domain//DWNN domain GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270//GO:0003676 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding//nucleic acid binding GO:0005634 nucleus KOG0314 Predicted E3 ubiquitin ligase Cluster-8309.47253 BF_2 41.96 0.35 5262 478250976 ENN71460.1 1070 2.9e-113 hypothetical protein YQE_11877, partial [Dendroctonus ponderosae]>gi|546682655|gb|ERL92567.1| hypothetical protein D910_09880 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P46941 324 3.8e-28 WW domain-containing protein tag-325 OS=Caenorhabditis elegans GN=tag-325 PE=3 SV=1 PF01437//PF02749//PF00620 Plexin repeat//Quinolinate phosphoribosyl transferase, N-terminal domain//RhoGAP domain GO:0007165 signal transduction GO:0016763 transferase activity, transferring pentosyl groups GO:0016020 membrane KOG1450 Predicted Rho GTPase-activating protein Cluster-8309.47257 BF_2 188.23 1.45 5717 478262859 ENN81341.1 1820 3.4e-200 hypothetical protein YQE_02252, partial [Dendroctonus ponderosae] 213513283 NM_001141934.1 389 0 Tribolium castaneum estrogen-related receptor (Err), mRNA K08703 NR3BN, ERR estrogen-related receptor ERR http://www.genome.jp/dbget-bin/www_bget?ko:K08703 O95718 803 1.2e-83 Steroid hormone receptor ERR2 OS=Homo sapiens GN=ESRRB PE=1 SV=2 PF00106//PF00104//PF01370//PF00105//PF00324 short chain dehydrogenase//Ligand-binding domain of nuclear hormone receptor//NAD dependent epimerase/dehydratase family//Zinc finger, C4 type (two domains)//Amino acid permease GO:0006810//GO:0055085//GO:0008152//GO:0006355//GO:0043401 transport//transmembrane transport//metabolic process//regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0016491//GO:0003824//GO:0050662//GO:0003700//GO:0008270//GO:0043565 oxidoreductase activity//catalytic activity//coenzyme binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0016020 transcription factor complex//nucleus//membrane -- -- Cluster-8309.47260 BF_2 59.41 0.75 3584 189234531 XP_967948.2 892 8.6e-93 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 704 2.2e-72 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF00324//PF03522 Amino acid permease//Amino acid permease//Solute carrier family 12 GO:0003333//GO:0006811//GO:0006865//GO:0055085//GO:0006810 amino acid transmembrane transport//ion transport//amino acid transport//transmembrane transport//transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.47261 BF_2 435.00 6.07 3286 546673947 ERL85458.1 3578 0.0e+00 hypothetical protein D910_02877 [Dendroctonus ponderosae] 657572521 XM_008291658.1 272 9.31089e-138 PREDICTED: Stegastes partitus ribonucleoside-diphosphate reductase large subunit (LOC103364515), mRNA K10807 RRM1 ribonucleoside-diphosphate reductase subunit M1 http://www.genome.jp/dbget-bin/www_bget?ko:K10807 P07742 3192 0.0e+00 Ribonucleoside-diphosphate reductase large subunit OS=Mus musculus GN=Rrm1 PE=1 SV=2 PF02867//PF00317 Ribonucleotide reductase, barrel domain//Ribonucleotide reductase, all-alpha domain GO:0009186//GO:0006144//GO:0006260//GO:0006206//GO:0055114 deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process//DNA replication//pyrimidine nucleobase metabolic process//oxidation-reduction process GO:0005524//GO:0004748 ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0005971 ribonucleoside-diphosphate reductase complex KOG1112 Ribonucleotide reductase, alpha subunit Cluster-8309.47262 BF_2 12.80 0.32 1977 91078036 XP_966313.1 1101 2.8e-117 PREDICTED: casein kinase II subunit beta [Tribolium castaneum]>gi|642914882|ref|XP_008190429.1| PREDICTED: casein kinase II subunit beta [Tribolium castaneum] 768429608 XM_011557689.1 206 2.72077e-101 PREDICTED: Plutella xylostella casein kinase II subunit beta (LOC105387020), mRNA K03115 CSNK2B casein kinase II subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03115 O76485 1031 1.5e-110 Casein kinase II subunit beta OS=Spodoptera frugiperda PE=2 SV=1 PF01214 Casein kinase II regulatory subunit GO:0045859 regulation of protein kinase activity GO:0019887 protein kinase regulator activity GO:0005956 protein kinase CK2 complex KOG3092 Casein kinase II, beta subunit Cluster-8309.47266 BF_2 22.00 0.67 1668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47268 BF_2 5.99 0.32 1064 768445485 XP_011564646.1 222 1.2e-15 PREDICTED: uncharacterized protein LOC105394441 isoform X2 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04136//PF02185//PF11427//PF10473//PF02050//PF07544//PF05531//PF02465//PF15233//PF01496//PF03462 Sec34-like family//Hr1 repeat//Tc3 transposase//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Flagellar FliJ protein//RNA polymerase II transcription mediator complex subunit 9//Nucleopolyhedrovirus P10 protein//Flagellar hook-associated protein 2 N-terminus//Synaptonemal complex central element protein 1//V-type ATPase 116kDa subunit family//PCRF domain GO:0006935//GO:0071973//GO:0006415//GO:0006357//GO:0015992//GO:0006449//GO:0007130//GO:0070193//GO:0015991//GO:0007165//GO:0007128//GO:0006886 chemotaxis//bacterial-type flagellum-dependent cell motility//translational termination//regulation of transcription from RNA polymerase II promoter//proton transport//regulation of translational termination//synaptonemal complex assembly//synaptonemal complex organization//ATP hydrolysis coupled proton transport//signal transduction//meiotic prophase I//intracellular protein transport GO:0003774//GO:0001104//GO:0045502//GO:0008134//GO:0042803//GO:0003677//GO:0016149//GO:0015078 motor activity//RNA polymerase II transcription cofactor activity//dynein binding//transcription factor binding//protein homodimerization activity//DNA binding//translation release factor activity, codon specific//hydrogen ion transmembrane transporter activity GO:0009424//GO:0030286//GO:0016592//GO:0005667//GO:0009288//GO:0018444//GO:0019028//GO:0000795//GO:0016020//GO:0033179//GO:0005801//GO:0005840//GO:0005737 bacterial-type flagellum hook//dynein complex//mediator complex//transcription factor complex//bacterial-type flagellum//translation release factor complex//viral capsid//synaptonemal complex//membrane//proton-transporting V-type ATPase, V0 domain//cis-Golgi network//ribosome//cytoplasm -- -- Cluster-8309.47270 BF_2 19.00 0.70 1421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47275 BF_2 116.59 3.17 1825 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47277 BF_2 26.54 0.32 3760 270014029 EFA10477.1 699 2.2e-70 hypothetical protein TcasGA2_TC012723 [Tribolium castaneum] 820846531 XM_003693206.2 65 1.2554e-22 PREDICTED: Apis florea TOX high mobility group box family member 3-like (LOC100869383), partial mRNA -- -- -- -- O94842 173 8.7e-11 TOX high mobility group box family member 4 OS=Homo sapiens GN=TOX4 PE=1 SV=1 PF03460//PF11770 Nitrite/Sulfite reductase ferredoxin-like half domain//GRB2-binding adapter (GAPT) GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity GO:0016021 integral component of membrane KOG0381 HMG box-containing protein Cluster-8309.47280 BF_2 156.00 7.24 1188 195429517 XP_002062805.1 222 1.4e-15 GK19503 [Drosophila willistoni]>gi|194158890|gb|EDW73791.1| GK19503 [Drosophila willistoni] -- -- -- -- -- -- -- -- -- Q54VM3 170 6.1e-11 TBC1 domain family member 5 homolog A OS=Dictyostelium discoideum GN=tbc1d5A PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47282 BF_2 756.51 14.07 2536 189237698 XP_970597.2 3338 0.0e+00 PREDICTED: protein shuttle craft [Tribolium castaneum] 642924172 XM_965504.3 284 1.52966e-144 PREDICTED: Tribolium castaneum protein shuttle craft (LOC659177), mRNA K12236 NFX1 transcriptional repressor NF-X1 http://www.genome.jp/dbget-bin/www_bget?ko:K12236 P40798 2285 7.4e-256 Protein shuttle craft OS=Drosophila melanogaster GN=stc PE=1 SV=2 PF01422//PF01424 NF-X1 type zinc finger//R3H domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0008270//GO:0003676 transcription factor activity, sequence-specific DNA binding//zinc ion binding//nucleic acid binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.47284 BF_2 731.29 15.93 2208 91090216 XP_968004.1 1600 4.2e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.5e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008146//GO:0008476 sulfotransferase activity//protein-tyrosine sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.47285 BF_2 306.48 3.27 4203 642921416 XP_008192857.1 2259 3.1e-251 PREDICTED: transmembrane protein 62 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P6H9 1134 3.6e-122 Transmembrane protein 62 OS=Homo sapiens GN=TMEM62 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47287 BF_2 408.00 2.76 6465 91079166 XP_967495.1 4861 0.0e+00 PREDICTED: HEAT repeat-containing protein 1 homolog [Tribolium castaneum]>gi|270003615|gb|EFA00063.1| hypothetical protein TcasGA2_TC002876 [Tribolium castaneum] -- -- -- -- -- K14550 UTP10, HEATR1 U3 small nucleolar RNA-associated protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14550 Q7SY48 1495 7.6e-164 HEAT repeat-containing protein 1 OS=Danio rerio GN=heatr1 PE=2 SV=1 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG1837 Uncharacterized conserved protein Cluster-8309.47293 BF_2 87.22 1.05 3767 270014679 EFA11127.1 650 1.0e-64 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 256 2.1e-20 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47296 BF_2 14.11 0.53 1400 642915536 XP_008190656.1 409 3.4e-37 PREDICTED: uncharacterized Golgi apparatus membrane protein-like protein CG5021 isoform X1 [Tribolium castaneum]>gi|270004023|gb|EFA00471.1| hypothetical protein TcasGA2_TC003329 [Tribolium castaneum] 571572836 XM_006565668.1 108 5.74744e-47 PREDICTED: Apis mellifera uncharacterized FAM18-like protein CG5021-like (LOC408503), transcript variant X6, mRNA -- -- -- -- Q8IQC1 373 2.1e-34 Uncharacterized Golgi apparatus membrane protein-like protein CG5021 OS=Drosophila melanogaster GN=CG5021 PE=2 SV=2 PF05832 Eukaryotic protein of unknown function (DUF846) -- -- -- -- GO:0016021 integral component of membrane KOG3195 Uncharacterized membrane protein NPD008/CGI-148 Cluster-8309.47298 BF_2 45.74 0.34 5874 642921136 XP_008192702.1 1068 5.5e-113 PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921138|ref|XP_008192703.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921140|ref|XP_008192704.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921142|ref|XP_008192706.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921144|ref|XP_008192707.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921146|ref|XP_008192708.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921148|ref|XP_008192709.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921150|ref|XP_008192710.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WVB4 224 1.7e-16 Slit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2 PF13855//PF15050//PF14991//PF13895 Leucine rich repeat//SCIMP protein//Protein melan-A//Immunoglobulin domain -- -- GO:0005515 protein binding GO:0016021//GO:0001772//GO:0042470//GO:0097197 integral component of membrane//immunological synapse//melanosome//tetraspanin-enriched microdomain -- -- Cluster-8309.47302 BF_2 189.65 2.26 3795 270002245 EEZ98692.1 1521 1.1e-165 hypothetical protein TcasGA2_TC001228 [Tribolium castaneum] -- -- -- -- -- K08187 SLC16A10 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K08187 Q91Y77 935 3.9e-99 Monocarboxylate transporter 10 OS=Rattus norvegicus GN=Slc16a10 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.47305 BF_2 256.00 2.75 4185 91094681 XP_967379.1 2293 3.5e-255 PREDICTED: beta-catenin-like protein 1 [Tribolium castaneum]>gi|270016504|gb|EFA12950.1| hypothetical protein TcasGA2_TC005070 [Tribolium castaneum] -- -- -- -- -- K12864 CTNNBL1 beta-catenin-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12864 Q8WYA6 1509 1.2e-165 Beta-catenin-like protein 1 OS=Homo sapiens GN=CTNNBL1 PE=1 SV=1 PF02985//PF02892//PF00782//PF00102//PF00514//PF11648//PF00096 HEAT repeat//BED zinc finger//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Armadillo/beta-catenin-like repeat//C-terminal domain of RIG-I//Zinc finger, C2H2 type GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0005515//GO:0004725//GO:0003677//GO:0046872//GO:0016817 protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//DNA binding//metal ion binding//hydrolase activity, acting on acid anhydrides -- -- KOG2734 Uncharacterized conserved protein Cluster-8309.47307 BF_2 55.46 0.57 4334 478263754 ENN82050.1 936 8.2e-98 hypothetical protein YQE_01563, partial [Dendroctonus ponderosae] -- -- -- -- -- K17083 FERMT2, KIND2 kindlin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17083 Q9VZI3 598 5.3e-60 Unc-112-related protein OS=Drosophila melanogaster GN=Fit1 PE=1 SV=1 PF00644 Poly(ADP-ribose) polymerase catalytic domain -- -- GO:0003950 NAD+ ADP-ribosyltransferase activity -- -- KOG3727 Mitogen inducible gene product (contains ERM and PH domains) Cluster-8309.47308 BF_2 147.00 1.33 4899 270005111 EFA01559.1 1885 8.4e-208 hypothetical protein TcasGA2_TC007120 [Tribolium castaneum] 642921112 XM_008194472.1 648 0 PREDICTED: Tribolium castaneum B-cell lymphoma/leukemia 11B (LOC664174), mRNA -- -- -- -- Q9NSJ1 214 2.0e-15 Putative zinc finger protein 355P OS=Homo sapiens GN=ZNF355P PE=5 SV=2 PF13912//PF07776//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.47309 BF_2 318.10 2.64 5328 478255001 ENN75234.1 3133 0.0e+00 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1964 2.6e-218 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06414//PF01637//PF03193//PF00005//PF01580//PF01926//PF13304//PF00664//PF00437 Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//FtsK/SpoIIIE family//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0003677//GO:0003924//GO:0000166//GO:0005525//GO:0016301//GO:0016887//GO:0042626 ATP binding//DNA binding//GTPase activity//nucleotide binding//GTP binding//kinase activity//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.4731 BF_2 72.00 3.73 1095 270008839 EFA05287.1 261 3.9e-20 hypothetical protein TcasGA2_TC015444 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GQU6 149 1.5e-08 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 3 OS=Mus musculus GN=Lingo3 PE=2 SV=2 PF00560//PF13855//PF14955 Leucine Rich Repeat//Leucine rich repeat//Mitochondrial ribosome subunit S24 -- -- GO:0005515 protein binding GO:0005739 mitochondrion KOG0619 FOG: Leucine rich repeat Cluster-8309.47310 BF_2 124.61 0.41 13083 225543470 NP_001139383.1 315 2.5e-25 serum response factor [Tribolium castaneum] 225543469 NM_001145911.1 123 2.51821e-54 Tribolium castaneum serum response factor (Srf), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47312 BF_2 278.31 2.76 4500 642931475 XP_008196599.1 1698 3.7e-186 PREDICTED: insulin receptor substrate 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 P84770 503 5.7e-49 Insulin receptor substrate 1-B OS=Xenopus laevis GN=irs1-b PE=2 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.47314 BF_2 81.64 0.71 5070 270011103 EFA07551.1 3565 0.0e+00 semaphorin-1a-like protein [Tribolium castaneum] 642930289 XM_008198109.1 776 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2582 5.4e-290 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF01403//PF01437//PF05700 Sema domain//Plexin repeat//Breast carcinoma amplified sequence 2 (BCAS2) GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.47315 BF_2 782.01 4.57 7452 270011103 EFA07551.1 3565 0.0e+00 semaphorin-1a-like protein [Tribolium castaneum] 642930289 XM_008198109.1 776 0 PREDICTED: Tribolium castaneum semaphorin-1A (LOC660780), transcript variant X2, mRNA K06842 SEMA6 semaphorin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K06842 Q24322 2582 7.9e-290 Semaphorin-1A OS=Drosophila melanogaster GN=Sema-1a PE=2 SV=2 PF01437//PF01403//PF05700 Plexin repeat//Sema domain//Breast carcinoma amplified sequence 2 (BCAS2) GO:0006397 mRNA processing GO:0005515 protein binding GO:0016020 membrane KOG3611 Semaphorins Cluster-8309.47317 BF_2 1426.03 6.18 9937 197276678 NP_001127849.1 4725 0.0e+00 patched [Tribolium castaneum]>gi|270015128|gb|EFA11576.1| patched [Tribolium castaneum] 197276677 NM_001134377.1 723 0 Tribolium castaneum patched (Ptc), mRNA K15013 ACSBG long-chain-fatty-acid--CoA ligase ACSBG http://www.genome.jp/dbget-bin/www_bget?ko:K15013 P18502 2167 1.4e-241 Protein patched OS=Drosophila melanogaster GN=ptc PE=2 SV=2 PF02116//PF00501//PF08941//PF16499//PF03572//PF02460 Fungal pheromone mating factor STE2 GPCR//AMP-binding enzyme//USP8 interacting//Alpha galactosidase A//Peptidase family S41//Patched family GO:0007165//GO:0007606//GO:0005975//GO:0007186//GO:0016567//GO:0008152//GO:0019236//GO:0006508 signal transduction//sensory perception of chemical stimulus//carbohydrate metabolic process//G-protein coupled receptor signaling pathway//protein ubiquitination//metabolic process//response to pheromone//proteolysis GO:0008158//GO:0031386//GO:0004553//GO:0008236//GO:0004932//GO:0016881//GO:0003824 hedgehog receptor activity//protein tag//hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type peptidase activity//mating-type factor pheromone receptor activity//acid-amino acid ligase activity//catalytic activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1935 Membrane protein Patched/PTCH Cluster-8309.47318 BF_2 90.70 0.91 4472 642937652 XP_966876.3 827 3.7e-85 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6B4Z5 368 2.5e-33 Zinc finger Y-chromosomal protein OS=Pan troglodytes GN=ZFY PE=2 SV=1 PF00096//PF13465//PF07649//PF02738 Zinc finger, C2H2 type//Zinc-finger double domain//C1-like domain//Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0047134//GO:0046872 oxidoreductase activity//protein-disulfide reductase activity//metal ion binding -- -- -- -- Cluster-8309.47320 BF_2 11.81 0.81 897 478253168 ENN73539.1 316 1.3e-26 hypothetical protein YQE_09790, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q867Z4 288 9.6e-25 Longitudinals lacking protein, isoforms F/I/K/T OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF01428//PF02892//PF01155//PF00096//PF13465 AN1-like Zinc finger//BED zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006464 cellular protein modification process GO:0008270//GO:0003677//GO:0016151//GO:0046872 zinc ion binding//DNA binding//nickel cation binding//metal ion binding -- -- -- -- Cluster-8309.47321 BF_2 22.00 0.99 1219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47322 BF_2 49.50 0.73 3137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47323 BF_2 36.04 0.62 2733 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47324 BF_2 18.96 0.32 2766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47325 BF_2 37.19 0.31 5315 847111375 XP_012814894.1 858 1.1e-88 PREDICTED: uncharacterized protein LOC105946753 [Xenopus (Silurana) tropicalis]>gi|847149816|ref|XP_012822809.1| PREDICTED: uncharacterized protein LOC105947875 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.47329 BF_2 13.04 1.00 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47330 BF_2 46.92 0.78 2794 642925558 XP_008194598.1 1188 3.2e-127 PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925560|ref|XP_008194599.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|642925562|ref|XP_008194600.1| PREDICTED: angiotensin-converting enzyme [Tribolium castaneum]>gi|270008677|gb|EFA05125.1| hypothetical protein TcasGA2_TC015240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6Q4G4 327 9.0e-29 Angiotensin-converting enzyme OS=Theromyzon tessulatum GN=ACE PE=2 SV=1 PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008237//GO:0008241 metallopeptidase activity//peptidyl-dipeptidase activity GO:0016020 membrane KOG3690 Angiotensin I-converting enzymes - M2 family peptidases Cluster-8309.47339 BF_2 235.00 3.92 2796 642913398 XP_008200993.1 1367 5.6e-148 PREDICTED: fruitless isoform X3 [Tribolium castaneum] 642913407 XM_008202776.1 250 1.34199e-125 PREDICTED: Tribolium castaneum fruitless (Fru), transcript variant X7, mRNA -- -- -- -- Q8IN81 552 7.3e-55 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00096//PF00651 Zinc finger, C2H2 type//BTB/POZ domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.47341 BF_2 157.60 3.47 2188 189234531 XP_967948.2 1727 7.9e-190 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 1438 1.1e-157 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006811//GO:0006810//GO:0055085 ion transport//transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.47344 BF_2 12.46 0.54 1261 91089745 XP_975162.1 578 7.8e-57 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 439 4.2e-42 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF07714//PF06293 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.47346 BF_2 10.00 0.36 1452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47349 BF_2 10.00 1.35 598 91089745 XP_975162.1 277 2.9e-22 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q1RMT7 222 2.9e-17 Serine/threonine-protein kinase RIO3 OS=Bos taurus GN=RIOK3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.4735 BF_2 25.05 0.56 2167 759162834 XP_011373103.1 547 5.2e-53 PREDICTED: uncharacterized protein LOC105301931 [Pteropus vampyrus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9Y6Q3 534 6.9e-53 Zinc finger protein 37 homolog OS=Homo sapiens GN=ZFP37 PE=2 SV=3 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47350 BF_2 176.79 5.11 1734 91089745 XP_975162.1 687 2.4e-69 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 O14730 404 6.6e-38 Serine/threonine-protein kinase RIO3 OS=Homo sapiens GN=RIOK3 PE=1 SV=2 PF07714//PF00069//PF06293 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.47351 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47353 BF_2 6.46 0.33 1111 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47355 BF_2 6.00 0.45 839 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47356 BF_2 7.29 0.37 1120 270007459 EFA03907.1 401 2.3e-36 hypothetical protein TcasGA2_TC014039 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 205 5.1e-15 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47360 BF_2 1.00 1.11 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47365 BF_2 21.07 0.32 3010 189235662 XP_001811794.1 377 3.8e-33 PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum]>gi|642917553|ref|XP_008191254.1| PREDICTED: uncharacterized protein LOC100142103 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47366 BF_2 48.61 0.57 3859 642921234 XP_008192774.1 1587 2.4e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921235 XM_008194553.1 286 1.80699e-145 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 677 3.2e-69 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF00023//PF14604//PF00018//PF03396//PF13606 Ankyrin repeat//Variant SH3 domain//SH3 domain//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Ankyrin repeat GO:0006206//GO:0006351//GO:0019083//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//viral transcription//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0005515 DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005730 nucleolus KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.47367 BF_2 32.42 0.65 2379 642921234 XP_008192774.1 1587 1.5e-173 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X3 [Tribolium castaneum] 642921233 XM_008194552.1 277 1.11614e-140 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X6, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q62415 386 1.1e-35 Apoptosis-stimulating of p53 protein 1 OS=Mus musculus GN=Ppp1r13b PE=2 SV=2 PF05188 MutS domain II GO:0006298 mismatch repair GO:0030983//GO:0005524 mismatched DNA binding//ATP binding -- -- -- -- Cluster-8309.47368 BF_2 192.00 6.45 1533 91086281 XP_973404.1 1589 5.5e-174 PREDICTED: alpha-N-acetylgalactosaminidase-like [Tribolium castaneum] -- -- -- -- -- K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 1151 1.4e-124 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF16499//PF02065 Alpha galactosidase A//Melibiase GO:0001575//GO:0046486//GO:0005975//GO:0006012 globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process//galactose metabolic process GO:0004557//GO:0004553 alpha-galactosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.47369 BF_2 59.58 0.51 5214 768954657 XP_011616057.1 422 3.9e-38 PREDICTED: zinc finger protein 595-like [Takifugu rubripes] -- -- -- -- -- -- -- -- -- E9QAG8 390 8.3e-36 Zinc finger protein 431 OS=Mus musculus GN=Znf431 PE=1 SV=1 PF13465//PF16622//PF05485//PF13912//PF02892//PF00096//PF06467//PF07776//PF17123 Zinc-finger double domain//zinc-finger C2H2-type//THAP domain//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//RING-like zinc finger -- -- GO:0003676//GO:0003677//GO:0008270//GO:0005515//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47370 BF_2 23.92 0.46 2481 270013290 EFA09738.1 1133 6.7e-121 hypothetical protein TcasGA2_TC011873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44386 520 3.3e-51 Integrin alpha-PS3 OS=Drosophila melanogaster GN=scb PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47371 BF_2 267.22 6.75 1942 91079056 XP_975139.1 1149 7.4e-123 PREDICTED: uncharacterized protein LOC664025 [Tribolium castaneum]>gi|270004195|gb|EFA00643.1| hypothetical protein TcasGA2_TC003519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47373 BF_2 631.00 18.59 1707 91079696 XP_968351.1 1157 7.6e-124 PREDICTED: rRNA 2'-O-methyltransferase fibrillarin [Tribolium castaneum]>gi|270003342|gb|EEZ99789.1| hypothetical protein TcasGA2_TC002569 [Tribolium castaneum] 746845440 XM_011054705.1 112 4.20717e-49 PREDICTED: Acromyrmex echinatior rRNA 2'-O-methyltransferase fibrillarin (LOC105145259), mRNA K14563 NOP1, FBL rRNA 2'-O-methyltransferase fibrillarin http://www.genome.jp/dbget-bin/www_bget?ko:K14563 Q8I1F4 1136 8.6e-123 rRNA 2'-O-methyltransferase fibrillarin OS=Drosophila erecta GN=Fib PE=3 SV=1 PF01189//PF08704//PF01269//PF01728//PF01135 16S rRNA methyltransferase RsmF//tRNA methyltransferase complex GCD14 subunit//Fibrillarin//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GO:0006479//GO:0009451//GO:0006364//GO:0032259//GO:0008033//GO:0046500//GO:0006464//GO:0030488 protein methylation//RNA modification//rRNA processing//methylation//tRNA processing//S-adenosylmethionine metabolic process//cellular protein modification process//tRNA methylation GO:0008168//GO:0004719//GO:0003723//GO:0016429 methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//RNA binding//tRNA (adenine-N1-)-methyltransferase activity GO:0031515 tRNA (m1A) methyltransferase complex KOG1596 Fibrillarin and related nucleolar RNA-binding proteins Cluster-8309.47374 BF_2 378.52 6.52 2714 642913646 XP_008201102.1 2668 7.5e-299 PREDICTED: uncharacterized family 31 glucosidase KIAA1161 isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZQ1 651 2.4e-66 Uncharacterized family 31 glucosidase KIAA1161 OS=Mus musculus GN=Kiaa1161 PE=1 SV=2 PF03539//PF01055 Spumavirus aspartic protease (A9)//Glycosyl hydrolases family 31 GO:0005975//GO:0006508 carbohydrate metabolic process//proteolysis GO:0004190//GO:0004553 aspartic-type endopeptidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.47379 BF_2 3.00 0.98 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47381 BF_2 8.00 0.79 709 642926739 XP_008194992.1 146 5.4e-07 PREDICTED: segment polarity protein dishevelled homolog DVL-3 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47382 BF_2 147.00 4.39 1688 571543791 XP_006561534.1 245 4.3e-18 PREDICTED: chaoptin-like isoform X2 [Apis mellifera]>gi|571543794|ref|XP_006561535.1| PREDICTED: chaoptin-like isoform X3 [Apis mellifera]>gi|571543797|ref|XP_006561536.1| PREDICTED: chaoptin-like isoform X4 [Apis mellifera]>gi|571543800|ref|XP_006561537.1| PREDICTED: chaoptin-like isoform X5 [Apis mellifera]>gi|571543803|ref|XP_006561538.1| PREDICTED: chaoptin-like isoform X6 [Apis mellifera]>gi|571543806|ref|XP_006561539.1| PREDICTED: chaoptin-like isoform X7 [Apis mellifera] -- -- -- -- -- -- -- -- -- D4A1J9 226 2.8e-17 Leucine-rich repeat and fibronectin type-III domain-containing protein 5 OS=Rattus norvegicus GN=Lrfn5 PE=1 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.47383 BF_2 225.50 4.67 2308 91085301 XP_968534.1 1697 2.5e-186 PREDICTED: scavenger receptor class B member 1 isoform X1 [Tribolium castaneum]>gi|270009220|gb|EFA05668.1| hypothetical protein TcasGA2_TC014946 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 521 2.4e-51 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.47387 BF_2 10.31 0.37 1443 45822209 CAE47501.1 828 9.1e-86 cathepsin L-like proteinase [Diabrotica virgifera virgifera] -- -- -- -- -- K01371 CTSK cathepsin K http://www.genome.jp/dbget-bin/www_bget?ko:K01371 Q26636 700 2.6e-72 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.47388 BF_2 8.42 0.44 1086 546681897 ERL91906.1 408 3.5e-37 hypothetical protein D910_09229 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P05049 275 3.8e-23 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.47391 BF_2 10.98 0.47 1261 861605580 KMQ84383.1 273 1.8e-21 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47392 BF_2 961.34 3.79 10888 270008428 EFA04876.1 9007 0.0e+00 hypothetical protein TcasGA2_TC014935 [Tribolium castaneum] -- -- -- -- -- K00888 PI4K phosphatidylinositol 4-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00888 P42356 4980 0.0e+00 Phosphatidylinositol 4-kinase alpha OS=Homo sapiens GN=PI4KA PE=1 SV=3 PF13181//PF07721//PF08240//PF00899//PF00454//PF00106//PF13374//PF00515//PF13414//PF00107 Tetratricopeptide repeat//Tetratricopeptide repeat//Alcohol dehydrogenase GroES-like domain//ThiF family//Phosphatidylinositol 3- and 4-kinase//short chain dehydrogenase//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Zinc-binding dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0042802//GO:0016773//GO:0016491//GO:0008641//GO:0005515 identical protein binding//phosphotransferase activity, alcohol group as acceptor//oxidoreductase activity//small protein activating enzyme activity//protein binding -- -- KOG0902 Phosphatidylinositol 4-kinase Cluster-8309.47393 BF_2 90.02 1.43 2912 642916768 XP_008192537.1 537 1.0e-51 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q9V3B7 310 8.8e-27 Peptidoglycan-recognition protein SC1a/b OS=Drosophila melanogaster GN=PGRP-SC1a PE=1 SV=1 PF01510//PF16647 N-acetylmuramoyl-L-alanine amidase//Granulocyte colony-stimulating factor GO:0006955//GO:0006807//GO:0009252//GO:0007165//GO:0009253 immune response//nitrogen compound metabolic process//peptidoglycan biosynthetic process//signal transduction//peptidoglycan catabolic process GO:0008745//GO:0005125 N-acetylmuramoyl-L-alanine amidase activity//cytokine activity GO:0005576 extracellular region -- -- Cluster-8309.47395 BF_2 77.19 0.49 6910 270015831 EFA12279.1 790 1.1e-80 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF08398//PF09106//PF02892 Zinc-finger double domain//Parvovirus coat protein VP1//Elongation factor SelB, winged helix//BED zinc finger GO:0001514//GO:0006448 selenocysteine incorporation//regulation of translational elongation GO:0003746//GO:0005525//GO:0046872//GO:0003677//GO:0003723//GO:0005198 translation elongation factor activity//GTP binding//metal ion binding//DNA binding//RNA binding//structural molecule activity GO:0005840//GO:0005737//GO:0019028 ribosome//cytoplasm//viral capsid -- -- Cluster-8309.47398 BF_2 61.77 2.87 1189 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47399 BF_2 7.00 1.16 540 321475291 EFX86254.1 737 1.2e-75 ribosomal protein-like protein S6 [Daphnia pulex] 6166341 AF154067.1 98 7.71966e-42 AF154067 Aedes aegypti ribosomal protein S6 mRNA, complete cds K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 P29327 707 1.5e-73 40S ribosomal protein S6 OS=Drosophila melanogaster GN=RpS6 PE=1 SV=1 PF01092 Ribosomal protein S6e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1646 40S ribosomal protein S6 Cluster-8309.47401 BF_2 148.27 2.84 2472 91089063 XP_970679.1 2031 5.0e-225 PREDICTED: N-sulphoglucosamine sulphohydrolase isoform X1 [Tribolium castaneum]>gi|270012406|gb|EFA08854.1| hypothetical protein TcasGA2_TC006555 [Tribolium castaneum] 584037463 XM_006753050.1 45 1.07821e-11 PREDICTED: Myotis davidii N-sulfoglucosamine sulfohydrolase (SGSH), partial mRNA K01565 SGSH N-sulfoglucosamine sulfohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01565 P51688 1498 1.3e-164 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens GN=SGSH PE=1 SV=1 PF09004//PF07931//PF01663//PF00884//PF02076//PF00010 Domain of unknown function (DUF1891)//Chloramphenicol phosphotransferase-like protein//Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase//Pheromone A receptor//Helix-loop-helix DNA-binding domain GO:0007606//GO:0019236//GO:0055114//GO:0007186//GO:0008152 sensory perception of chemical stimulus//response to pheromone//oxidation-reduction process//G-protein coupled receptor signaling pathway//metabolic process GO:0004932//GO:0008484//GO:0008168//GO:0016706//GO:0046983//GO:0016740//GO:0003824//GO:0005524 mating-type factor pheromone receptor activity//sulfuric ester hydrolase activity//methyltransferase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein dimerization activity//transferase activity//catalytic activity//ATP binding GO:0016021 integral component of membrane KOG3867 Sulfatase Cluster-8309.47402 BF_2 134.93 2.63 2435 91089063 XP_970679.1 2031 4.9e-225 PREDICTED: N-sulphoglucosamine sulphohydrolase isoform X1 [Tribolium castaneum]>gi|270012406|gb|EFA08854.1| hypothetical protein TcasGA2_TC006555 [Tribolium castaneum] 584037463 XM_006753050.1 45 1.06184e-11 PREDICTED: Myotis davidii N-sulfoglucosamine sulfohydrolase (SGSH), partial mRNA K01565 SGSH N-sulfoglucosamine sulfohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01565 P51688 1498 1.3e-164 N-sulphoglucosamine sulphohydrolase OS=Homo sapiens GN=SGSH PE=1 SV=1 PF00010//PF02076//PF00884//PF07931//PF01663//PF09004 Helix-loop-helix DNA-binding domain//Pheromone A receptor//Sulfatase//Chloramphenicol phosphotransferase-like protein//Type I phosphodiesterase / nucleotide pyrophosphatase//Domain of unknown function (DUF1891) GO:0007606//GO:0019236//GO:0055114//GO:0007186//GO:0008152 sensory perception of chemical stimulus//response to pheromone//oxidation-reduction process//G-protein coupled receptor signaling pathway//metabolic process GO:0004932//GO:0008168//GO:0008484//GO:0016706//GO:0046983//GO:0016740//GO:0005524//GO:0003824 mating-type factor pheromone receptor activity//methyltransferase activity//sulfuric ester hydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors//protein dimerization activity//transferase activity//ATP binding//catalytic activity GO:0016021 integral component of membrane KOG3867 Sulfatase Cluster-8309.47406 BF_2 57.12 0.96 2789 242018392 XP_002429661.1 645 2.9e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 3.4e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47410 BF_2 157.21 2.22 3254 642927491 XP_008195289.1 730 4.8e-74 PREDICTED: uncharacterized protein LOC103313551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02076//PF05550 Pheromone A receptor//Pestivirus Npro endopeptidase C53 GO:0019082//GO:0007186//GO:0016032//GO:0019236//GO:0007606 viral protein processing//G-protein coupled receptor signaling pathway//viral process//response to pheromone//sensory perception of chemical stimulus GO:0004932 mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.47416 BF_2 24.00 0.34 3230 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47419 BF_2 16.35 1.42 770 642922539 XP_008193217.1 573 1.8e-56 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SPP0 239 4.0e-19 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47420 BF_2 169.78 2.71 2906 642922539 XP_008193217.1 573 6.8e-56 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SPP0 239 1.5e-18 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47422 BF_2 88.11 11.07 620 642922539 XP_008193217.1 573 1.4e-56 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SPP0 239 3.2e-19 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47423 BF_2 89.64 3.03 1526 270008621 EFA05069.1 151 3.1e-07 hypothetical protein TcasGA2_TC015166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47424 BF_2 362.83 10.88 1682 478256678 ENN76860.1 772 3.3e-79 hypothetical protein YQE_06701, partial [Dendroctonus ponderosae]>gi|546685125|gb|ERL94652.1| hypothetical protein D910_11927 [Dendroctonus ponderosae] -- -- -- -- -- K02602 CPEB, ORB cytoplasmic polyadenylation element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K02602 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47425 BF_2 236.49 4.03 2739 642916439 XP_008191027.1 1004 6.8e-106 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 430 1.0e-40 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF00606//PF10459//PF08651//PF06814//PF04111//PF05073//PF11744//PF00046//PF02184//PF09036//PF09392//PF02601//PF08702//PF05929//PF05478//PF01496 Herpesvirus Glycoprotein B//Peptidase S46//DASH complex subunit Duo1//Lung seven transmembrane receptor//Autophagy protein Apg6//Baculovirus P24 capsid protein//Aluminium activated malate transporter//Homeobox domain//HAT (Half-A-TPR) repeat//Bcr-Abl oncoprotein oligomerisation domain//Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin//V-type ATPase 116kDa subunit family GO:0015031//GO:0007067//GO:0051258//GO:0006468//GO:0009069//GO:0006914//GO:0007165//GO:0009405//GO:0019069//GO:0006308//GO:0015743//GO:0015991//GO:0015992//GO:0006396//GO:0030168//GO:0016310 protein transport//mitotic nuclear division//protein polymerization//protein phosphorylation//serine family amino acid metabolic process//autophagy//signal transduction//pathogenesis//viral capsid assembly//DNA catabolic process//malate transport//ATP hydrolysis coupled proton transport//proton transport//RNA processing//platelet activation//phosphorylation GO:0015078//GO:0070009//GO:0005096//GO:0008855//GO:0003677//GO:0004674//GO:0005102//GO:0008239//GO:0030674 hydrogen ion transmembrane transporter activity//serine-type aminopeptidase activity//GTPase activator activity//exodeoxyribonuclease VII activity//DNA binding//protein serine/threonine kinase activity//receptor binding//dipeptidyl-peptidase activity//protein binding, bridging GO:0042729//GO:0005622//GO:0016021//GO:0033179//GO:0016020//GO:0005577//GO:0009318//GO:0019028//GO:0072686 DASH complex//intracellular//integral component of membrane//proton-transporting V-type ATPase, V0 domain//membrane//fibrinogen complex//exodeoxyribonuclease VII complex//viral capsid//mitotic spindle KOG3850 Predicted membrane protein Cluster-8309.47426 BF_2 279.57 11.59 1296 642939241 XP_008194774.1 1252 5.6e-135 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q4JM44 411 7.6e-39 Phosphatidylcholine:ceramide cholinephosphotransferase 2 OS=Rattus norvegicus GN=Sgms2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.47429 BF_2 15.53 1.97 617 642913461 XP_008201022.1 661 9.0e-67 PREDICTED: uncharacterized protein LOC663795 [Tribolium castaneum] -- -- -- -- -- K07524 RGS3 regulator of G-protein signalling 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07524 P17252 128 2.4e-06 Protein kinase C alpha type OS=Homo sapiens GN=PRKCA PE=1 SV=4 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG0696 Serine/threonine protein kinase Cluster-8309.47430 BF_2 76.60 2.30 1683 642914933 XP_008190447.1 345 1.1e-29 PREDICTED: serine/arginine repetitive matrix protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12300 Protein of unknown function (DUF3628) -- -- GO:0016817 hydrolase activity, acting on acid anhydrides -- -- -- -- Cluster-8309.47431 BF_2 221.31 2.36 4203 642929562 XP_008195885.1 2014 7.9e-223 PREDICTED: ankyrin repeat and IBR domain-containing protein 1-like [Tribolium castaneum]>gi|270010556|gb|EFA07004.1| hypothetical protein TcasGA2_TC009974 [Tribolium castaneum] 642929561 XM_008197663.1 153 1.69304e-71 PREDICTED: Tribolium castaneum ankyrin repeat and IBR domain-containing protein 1-like (LOC664247), mRNA -- -- -- -- -- -- -- -- -- -- -- -- GO:0043169 cation binding -- -- -- -- Cluster-8309.47434 BF_2 5.79 0.32 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47435 BF_2 290.17 4.55 2956 91088353 XP_971591.1 1440 2.0e-156 PREDICTED: alpha/beta hydrolase domain-containing protein 13 [Tribolium castaneum]>gi|270011778|gb|EFA08226.1| hypothetical protein TcasGA2_TC005853 [Tribolium castaneum] -- -- -- -- -- K06889 K06889 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06889 Q7L211 757 1.3e-78 Alpha/beta hydrolase domain-containing protein 13 OS=Homo sapiens GN=ABHD13 PE=2 SV=1 PF01738//PF01764//PF02230//PF07859//PF00326//PF07819 Dienelactone hydrolase family//Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Prolyl oligopeptidase family//PGAP1-like protein GO:0006508//GO:0006505//GO:0008152//GO:0006886//GO:0006629 proteolysis//GPI anchor metabolic process//metabolic process//intracellular protein transport//lipid metabolic process GO:0008236//GO:0016788//GO:0016787 serine-type peptidase activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- KOG4391 Predicted alpha/beta hydrolase BEM46 Cluster-8309.47438 BF_2 111.19 4.69 1280 91084687 XP_968830.1 287 4.4e-23 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] -- -- -- -- -- K18082 MTMR3_4, ZFYVE10_11 myotubularin-related protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18082 Q9NYA4 130 2.9e-06 Myotubularin-related protein 4 OS=Homo sapiens GN=MTMR4 PE=1 SV=2 PF13639//PF01363 Ring finger domain//FYVE zinc finger GO:0006470//GO:0006570//GO:0035335 protein dephosphorylation//tyrosine metabolic process//peptidyl-tyrosine dephosphorylation GO:0005515//GO:0046872//GO:0004725//GO:0008270 protein binding//metal ion binding//protein tyrosine phosphatase activity//zinc ion binding -- -- -- -- Cluster-8309.47439 BF_2 538.00 9.87 2567 91078584 XP_971954.1 1057 4.5e-112 PREDICTED: 3-hydroxyacyl-CoA dehydrogenase type-2 [Tribolium castaneum]>gi|270004043|gb|EFA00491.1| hypothetical protein TcasGA2_TC003351 [Tribolium castaneum] 769864511 XM_011645839.1 68 1.8352e-24 PREDICTED: Pogonomyrmex barbatus 3-hydroxyacyl-CoA dehydrogenase type-2 (LOC105431577), mRNA K08683 HSD17B10 3-hydroxyacyl-CoA dehydrogenase / 3-hydroxy-2-methylbutyryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K08683 O18404 946 1.4e-100 3-hydroxyacyl-CoA dehydrogenase type-2 OS=Drosophila melanogaster GN=scu PE=1 SV=1 PF01370//PF01073//PF00106 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase GO:0008207//GO:0055114//GO:0006694//GO:0008209//GO:0008210//GO:0008152 C21-steroid hormone metabolic process//oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//estrogen metabolic process//metabolic process GO:0000166//GO:0003854//GO:0050662//GO:0003824//GO:0016491//GO:0016616 nucleotide binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG1199 Short-chain alcohol dehydrogenase/3-hydroxyacyl-CoA dehydrogenase Cluster-8309.47440 BF_2 270.14 1.64 7175 642927083 XP_008195130.1 5734 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927084 XM_008196909.1 473 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X2, mRNA -- -- -- -- Q9ULI1 411 4.2e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF07728//PF00004//PF03193//PF00005//PF00400//PF01637//PF00910//PF00931 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//WD domain, G-beta repeat//Archaeal ATPase//RNA helicase//NB-ARC domain -- -- GO:0005524//GO:0003723//GO:0043531//GO:0005515//GO:0003924//GO:0005525//GO:0016887//GO:0003724 ATP binding//RNA binding//ADP binding//protein binding//GTPase activity//GTP binding//ATPase activity//RNA helicase activity -- -- -- -- Cluster-8309.47441 BF_2 143.94 0.86 7304 642927083 XP_008195130.1 5360 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927082 XM_008196908.1 520 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X1, mRNA -- -- -- -- Q9ULI1 411 4.3e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF03193//PF07728//PF00005//PF01637//PF00004//PF00931//PF00910 Protein of unknown function, DUF258//AAA domain (dynein-related subfamily)//ABC transporter//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//NB-ARC domain//RNA helicase -- -- GO:0003924//GO:0003724//GO:0043531//GO:0016887//GO:0003723//GO:0005525//GO:0005524 GTPase activity//RNA helicase activity//ADP binding//ATPase activity//RNA binding//GTP binding//ATP binding -- -- -- -- Cluster-8309.47444 BF_2 4.00 0.57 583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47445 BF_2 685.28 8.30 3739 321462910 EFX73930.1 533 3.8e-51 hypothetical protein DAPPUDRAFT_307535 [Daphnia pulex] -- -- -- -- -- -- -- -- -- Q6UWB4 293 1.1e-24 Serine protease 55 OS=Homo sapiens GN=PRSS55 PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.47447 BF_2 55.25 1.16 2284 270009116 EFA05564.1 1983 1.7e-219 hypothetical protein TcasGA2_TC015753 [Tribolium castaneum] 642926575 XM_008196705.1 163 2.52348e-77 PREDICTED: Tribolium castaneum putative fatty acyl-CoA reductase CG5065 (LOC656109), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1034 7.7e-111 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01073//PF01118//PF01370//PF03015 3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Male sterility protein GO:0008209//GO:0055114//GO:0006694//GO:0008207//GO:0008210 androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0016616//GO:0051287//GO:0050662//GO:0003824//GO:0003854 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.47448 BF_2 1210.00 42.61 1475 91084139 XP_976149.1 334 1.8e-28 PREDICTED: chromo domain-containing protein cec-1 [Tribolium castaneum]>gi|270006667|gb|EFA03115.1| hypothetical protein TcasGA2_TC013025 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.47449 BF_2 1751.94 8.96 8470 642911559 XP_970343.3 5242 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4083 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF04851//PF00176//PF04689//PF08074//PF03808 Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//DNA binding protein S1FA//CHDCT2 (NUC038) domain//Glycosyl transferase WecB/TagA/CpsF family GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0008270//GO:0016818//GO:0005524//GO:0003677//GO:0016787 zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//DNA binding//hydrolase activity GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.47450 BF_2 603.21 6.15 4387 91084287 XP_966951.1 533 4.5e-51 PREDICTED: rhythmically expressed gene 5 protein [Tribolium castaneum]>gi|270008733|gb|EFA05181.1| hypothetical protein TcasGA2_TC015311 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94913 211 4.0e-15 Rhythmically expressed gene 5 protein OS=Drosophila melanogaster GN=Reg-5 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47451 BF_2 17.05 0.38 2164 478252879 ENN73268.1 277 1.1e-21 hypothetical protein YQE_10163, partial [Dendroctonus ponderosae]>gi|546673885|gb|ERL85407.1| hypothetical protein D910_02827, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47455 BF_2 64.79 0.55 5258 91081873 XP_968521.1 1429 6.8e-155 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 4.92931e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence K16717 CEP97 centrosomal protein CEP97 http://www.genome.jp/dbget-bin/www_bget?ko:K16717 Q8IW35 304 7.9e-26 Centrosomal protein of 97 kDa OS=Homo sapiens GN=CEP97 PE=1 SV=1 PF00612//PF01984//PF05531//PF13855 IQ calmodulin-binding motif//Double-stranded DNA-binding domain//Nucleopolyhedrovirus P10 protein//Leucine rich repeat -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0019028 viral capsid KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.47456 BF_2 308.58 3.59 3885 91081873 XP_968521.1 2216 2.8e-246 PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|642921577|ref|XP_008192430.1| PREDICTED: centrosomal protein of 97 kDa [Tribolium castaneum]>gi|270005016|gb|EFA01464.1| hypothetical protein TcasGA2_TC007010 [Tribolium castaneum] 462361277 APGK01029116.1 57 3.63327e-18 Dendroctonus ponderosae Seq01029126, whole genome shotgun sequence K16717 CEP97 centrosomal protein CEP97 http://www.genome.jp/dbget-bin/www_bget?ko:K16717 Q8IW35 751 8.6e-78 Centrosomal protein of 97 kDa OS=Homo sapiens GN=CEP97 PE=1 SV=1 PF00560//PF00612//PF05531//PF13855 Leucine Rich Repeat//IQ calmodulin-binding motif//Nucleopolyhedrovirus P10 protein//Leucine rich repeat -- -- GO:0005515 protein binding GO:0019028 viral capsid KOG0531 Protein phosphatase 1, regulatory subunit, and related proteins Cluster-8309.47457 BF_2 343.65 5.04 3139 642916792 XP_008199505.1 1678 5.4e-184 PREDICTED: deformed epidermal autoregulatory factor 1 [Tribolium castaneum]>gi|270003059|gb|EEZ99506.1| hypothetical protein TcasGA2_TC000085 [Tribolium castaneum] 642916791 XM_008201283.1 177 5.74247e-85 PREDICTED: Tribolium castaneum deformed epidermal autoregulatory factor 1 (LOC655086), mRNA -- -- -- -- O88450 347 4.9e-31 Deformed epidermal autoregulatory factor 1 homolog OS=Rattus norvegicus GN=Deaf1 PE=1 SV=1 PF08064//PF00125//PF01342//PF15460 UME (NUC010) domain//Core histone H2A/H2B/H3/H4//SAND domain//Something about silencing, SAS, complex subunit 4 GO:0016310//GO:0009069//GO:0016573 phosphorylation//serine family amino acid metabolic process//histone acetylation GO:0004674//GO:0046872//GO:0003677//GO:0008270 protein serine/threonine kinase activity//metal ion binding//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.47458 BF_2 5.21 0.37 871 91078698 XP_971450.1 677 1.8e-68 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 569 2.4e-57 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47459 BF_2 40.43 3.17 821 91078698 XP_971450.1 840 2.1e-87 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q5ZKN1 659 8.4e-68 Cyclin-dependent kinase 9 OS=Gallus gallus GN=CDK9 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47461 BF_2 6.00 0.58 718 91078698 XP_971450.1 558 9.2e-55 PREDICTED: cyclin-dependent kinase 9 [Tribolium castaneum]>gi|270004079|gb|EFA00527.1| hypothetical protein TcasGA2_TC003392 [Tribolium castaneum] -- -- -- -- -- K02211 CDK9 cyclin-dependent kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K02211 Q6GLD8 508 2.4e-50 Cyclin-dependent kinase 9 OS=Xenopus tropicalis GN=cdk9 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0600 Cdc2-related protein kinase Cluster-8309.47464 BF_2 277.48 3.87 3286 646714573 KDR18486.1 3080 0.0e+00 Leucine-zipper-like transcriptional regulator 1 [Zootermopsis nevadensis] 527245427 XM_005140996.1 147 2.8583e-68 PREDICTED: Melopsittacus undulatus leucine-zipper-like transcription regulator 1 (LOC101875977), partial mRNA -- -- -- -- Q9CQ33 1429 1.7e-156 Leucine-zipper-like transcriptional regulator 1 OS=Mus musculus GN=Lztr1 PE=2 SV=2 PF03089//PF01344//PF11648//PF00651//PF07646 Recombination activating protein 2//Kelch motif//C-terminal domain of RIG-I//BTB/POZ domain//Kelch motif GO:0006310 DNA recombination GO:0003677//GO:0005515//GO:0016817 DNA binding//protein binding//hydrolase activity, acting on acid anhydrides GO:0005634 nucleus KOG0379 Kelch repeat-containing proteins Cluster-8309.47468 BF_2 643.00 4.84 5849 546682311 ERL92264.1 783 6.1e-80 hypothetical protein D910_09581 [Dendroctonus ponderosae] -- -- -- -- -- K15113 SLC25A28_37, MFRN solute carrier family 25 (mitochondrial iron transporter), member 28/37 http://www.genome.jp/dbget-bin/www_bget?ko:K15113 Q66H23 495 6.2e-48 Mitoferrin-1 OS=Rattus norvegicus GN=Slc25a37 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0760 Mitochondrial carrier protein MRS3/4 Cluster-8309.47469 BF_2 18.15 0.34 2542 642923795 XP_008193886.1 1065 5.3e-113 PREDICTED: uncharacterized protein LOC663689 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07650//PF00013//PF04999//PF13014 KH domain//KH domain//Cell division protein FtsL//KH domain GO:0051301//GO:0007049 cell division//cell cycle GO:0003723 RNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.4747 BF_2 5.38 0.34 957 642940190 XP_008200552.1 507 1.0e-48 PREDICTED: uncharacterized protein LOC103314959 isoform X2 [Tribolium castaneum]>gi|642940192|ref|XP_008200553.1| PREDICTED: uncharacterized protein LOC103314959 isoform X2 [Tribolium castaneum]>gi|270017054|gb|EFA13500.1| hypothetical protein TcasGA2_TC004259 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47470 BF_2 33.99 1.07 1618 635120339 XP_007983241.1 348 4.7e-30 PREDICTED: histone-lysine N-methyltransferase SETMAR [Chlorocebus sabaeus] 687869404 LK939364.1 75 1.47374e-28 Angiostrongylus costaricensis genome assembly A_costaricensis_Costa_Rica ,scaffold ACOC_scaffold0000209 K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q53H47 345 4.3e-31 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF09339//PF01047//PF01498//PF01022//PF01325//PF00440//PF13404 IclR helix-turn-helix domain//MarR family//Transposase//Bacterial regulatory protein, arsR family//Iron dependent repressor, N-terminal DNA binding domain//Bacterial regulatory proteins, tetR family//AsnC-type helix-turn-helix domain GO:0015074//GO:0006313//GO:0006355 DNA integration//transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.47471 BF_2 16.73 0.81 1154 1263081 AAC52010.1 780 2.7e-80 mariner transposase [Homo sapiens] 689770398 LM265316.1 319 2.39576e-164 Strongylus vulgaris genome assembly S_vulgaris_Kentucky ,scaffold SVUK_scaffold0039628 K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q53H47 717 2.2e-74 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47475 BF_2 196.36 2.77 3252 642913555 XP_008201060.1 2186 7.0e-243 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X1 [Tribolium castaneum] 642913556 XM_967014.3 616 0 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X2, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 1249 1.3e-135 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF00324//PF01194//PF04544//PF13520 Amino acid permease//RNA polymerases N / 8 kDa subunit//Herpesvirus egress protein UL20//Amino acid permease GO:0003333//GO:0006206//GO:0055085//GO:0006351//GO:0006865//GO:0006810//GO:0019058//GO:0006144 amino acid transmembrane transport//pyrimidine nucleobase metabolic process//transmembrane transport//transcription, DNA-templated//amino acid transport//transport//viral life cycle//purine nucleobase metabolic process GO:0015171//GO:0003677//GO:0003899 amino acid transmembrane transporter activity//DNA binding//DNA-directed RNA polymerase activity GO:0016020//GO:0005730 membrane//nucleolus -- -- Cluster-8309.47476 BF_2 374.94 5.20 3305 642913555 XP_008201060.1 2234 1.9e-248 PREDICTED: b(0,+)-type amino acid transporter 1 isoform X1 [Tribolium castaneum] 642913554 XM_008202838.1 620 0 PREDICTED: Tribolium castaneum b(0,+)-type amino acid transporter 1 (LOC660811), transcript variant X1, mRNA K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 P82252 1249 1.3e-135 b(0,+)-type amino acid transporter 1 OS=Rattus norvegicus GN=Slc7a9 PE=1 SV=1 PF00324//PF01194//PF13520//PF04544 Amino acid permease//RNA polymerases N / 8 kDa subunit//Amino acid permease//Herpesvirus egress protein UL20 GO:0003333//GO:0006206//GO:0006810//GO:0006144//GO:0019058//GO:0055085//GO:0006351//GO:0006865 amino acid transmembrane transport//pyrimidine nucleobase metabolic process//transport//purine nucleobase metabolic process//viral life cycle//transmembrane transport//transcription, DNA-templated//amino acid transport GO:0003677//GO:0015171//GO:0003899 DNA binding//amino acid transmembrane transporter activity//DNA-directed RNA polymerase activity GO:0005730//GO:0016020 nucleolus//membrane -- -- Cluster-8309.47477 BF_2 21.01 0.50 2054 91085955 XP_971224.1 1612 1.6e-176 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q75QN2 565 1.7e-56 Integrator complex subunit 8 OS=Homo sapiens GN=INTS8 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47478 BF_2 734.77 107.14 574 291170322 ADD82417.1 469 1.5e-44 minus-C odorant binding protein 4 [Batocera horsfieldi] 291170321 GU584934.1 247 1.22236e-124 Batocera horsfieldi minus-C odorant binding protein 4 mRNA, complete cds -- -- -- -- Q27017 132 7.6e-07 B1 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.47479 BF_2 476.00 1.27 15974 642938845 XP_972555.3 12736 0.0e+00 PREDICTED: midasin [Tribolium castaneum] -- -- -- -- -- K14572 MDN1, REA1 midasin http://www.genome.jp/dbget-bin/www_bget?ko:K14572 Q9NU22 4992 0.0e+00 Midasin OS=Homo sapiens GN=MDN1 PE=1 SV=2 PF10662//PF00910//PF03193//PF07726//PF00005//PF02367//PF00437//PF00004//PF00448//PF07728//PF14532//PF01695//PF00158//PF06068//PF05496 Ethanolamine utilisation - propanediol utilisation//RNA helicase//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA)//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA)//SRP54-type protein, GTPase domain//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus GO:0006281//GO:0006810//GO:0006614//GO:0006355//GO:0006576//GO:0006310//GO:0002949 DNA repair//transport//SRP-dependent cotranslational protein targeting to membrane//regulation of transcription, DNA-templated//cellular biogenic amine metabolic process//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0003924//GO:0005524//GO:0016887//GO:0003723//GO:0003678//GO:0003724//GO:0009378//GO:0005525 transcription factor binding//GTPase activity//ATP binding//ATPase activity//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity//GTP binding GO:0009379//GO:0005667//GO:0005657 Holliday junction helicase complex//transcription factor complex//replication fork KOG1808 AAA ATPase containing von Willebrand factor type A (vWA) domain Cluster-8309.4748 BF_2 2.00 0.62 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47481 BF_2 488.22 7.80 2907 332376294 AEE63287.1 1800 3.6e-198 unknown [Dendroctonus ponderosae]>gi|478257770|gb|ENN77913.1| hypothetical protein YQE_05590, partial [Dendroctonus ponderosae] 642933156 XM_968826.3 47 9.81639e-13 PREDICTED: Tribolium castaneum trehalase (LOC662746), transcript variant X2, mRNA K01194 E3.2.1.28, treA, treF alpha,alpha-trehalase http://www.genome.jp/dbget-bin/www_bget?ko:K01194 P32359 1648 6.2e-182 Trehalase OS=Tenebrio molitor PE=2 SV=1 PF01204 Trehalase GO:0005982//GO:0005985//GO:0005991 starch metabolic process//sucrose metabolic process//trehalose metabolic process GO:0004555 alpha,alpha-trehalase activity -- -- KOG0602 Neutral trehalase Cluster-8309.47485 BF_2 118.00 1.10 4766 270001609 EEZ98056.1 2859 0.0e+00 hypothetical protein TcasGA2_TC000461 [Tribolium castaneum] 827556978 XM_004930671.2 65 1.59454e-22 PREDICTED: Bombyx mori major facilitator superfamily domain-containing protein 6 (LOC101746863), mRNA -- -- -- -- Q1LUQ4 968 7.2e-103 Major facilitator superfamily domain-containing protein 6-A OS=Danio rerio GN=mfsd6a PE=3 SV=1 PF07690//PF01306 Major Facilitator Superfamily//LacY proton/sugar symporter GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG3762 Predicted transporter Cluster-8309.47486 BF_2 20.00 0.32 2882 827556337 XP_012549527.1 234 1.4e-16 PREDICTED: multiple inositol polyphosphate phosphatase 1 isoform X2 [Bombyx mori] -- -- -- -- -- K03103 MINPP1 multiple inositol-polyphosphate phosphatase / 2,3-bisphosphoglycerate 3-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K03103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47487 BF_2 3.00 0.33 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47491 BF_2 392.53 9.57 2003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47494 BF_2 9.00 1.03 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47495 BF_2 887.25 22.41 1943 642914567 XP_008190268.1 327 1.5e-27 PREDICTED: uncharacterized protein LOC103312147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47496 BF_2 9.00 0.82 744 642937396 XP_008198820.1 689 6.1e-70 PREDICTED: innexin shaking-B isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1DH70 384 5.9e-36 Innexin shaking-B OS=Aedes aegypti GN=shakB PE=3 SV=1 PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.47497 BF_2 462.19 7.74 2786 478255924 ENN76126.1 1824 5.7e-201 hypothetical protein YQE_07346, partial [Dendroctonus ponderosae]>gi|546676527|gb|ERL87521.1| hypothetical protein D910_04913 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1DH70 1482 1.1e-162 Innexin shaking-B OS=Aedes aegypti GN=shakB PE=3 SV=1 PF00876//PF06753 Innexin//Bradykinin GO:0007165//GO:0006950 signal transduction//response to stress GO:0005179 hormone activity GO:0005921//GO:0005576 gap junction//extracellular region -- -- Cluster-8309.47498 BF_2 4.23 0.42 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47499 BF_2 14.00 31.01 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47500 BF_2 47.00 5.48 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47505 BF_2 58.70 1.07 2578 642939069 XP_008200209.1 1427 5.7e-155 PREDICTED: HIV Tat-specific factor 1 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K13093 HTATSF1 HIV Tat-specific factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13093 Q5RB63 749 9.7e-78 HIV Tat-specific factor 1 homolog OS=Pongo abelii GN=HTATSF1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1548 Transcription elongation factor TAT-SF1 Cluster-8309.47507 BF_2 254.14 17.18 906 642917710 XP_008191340.1 397 5.4e-36 PREDICTED: ninjurin-1 [Tribolium castaneum]>gi|270003379|gb|EEZ99826.1| hypothetical protein TcasGA2_TC002607 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 184 1.1e-12 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF02724//PF06459 Ninjurin//CDC45-like protein//Ryanodine Receptor TM 4-6 GO:0007155//GO:0006874//GO:0006816//GO:0006270//GO:0042246 cell adhesion//cellular calcium ion homeostasis//calcium ion transport//DNA replication initiation//tissue regeneration GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.47509 BF_2 290.00 17.51 980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47510 BF_2 279.37 2.98 4204 91076340 XP_971067.1 2071 2.0e-229 PREDICTED: peroxisomal N(1)-acetyl-spermine/spermidine oxidase [Tribolium castaneum]>gi|270002541|gb|EEZ98988.1| hypothetical protein TcasGA2_TC004849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q865R1 687 2.4e-70 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Bos taurus GN=PAOX PE=1 SV=3 PF06100//PF01266//PF00979//PF01134//PF00899//PF01494//PF07992//PF01593 MCRA family//FAD dependent oxidoreductase//Reovirus outer capsid protein, Sigma 3//Glucose inhibited division protein A//ThiF family//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase GO:0006631//GO:0055114//GO:0008033//GO:0019058 fatty acid metabolic process//oxidation-reduction process//tRNA processing//viral life cycle GO:0050660//GO:0008641//GO:0071949//GO:0005198//GO:0050151//GO:0016491 flavin adenine dinucleotide binding//small protein activating enzyme activity//FAD binding//structural molecule activity//oleate hydratase activity//oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.47511 BF_2 20.54 0.36 2659 332374794 AEE62538.1 706 2.4e-71 unknown [Dendroctonus ponderosae]>gi|546674015|gb|ERL85508.1| hypothetical protein D910_02927 [Dendroctonus ponderosae] -- -- -- -- -- K01444 AGA, aspG N4-(beta-N-acetylglucosaminyl)-L-asparaginase http://www.genome.jp/dbget-bin/www_bget?ko:K01444 Q64191 653 1.4e-66 N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase OS=Mus musculus GN=Aga PE=2 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1593 Asparaginase Cluster-8309.47512 BF_2 3.00 0.81 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47514 BF_2 2126.55 39.84 2520 270006157 EFA02605.1 2232 2.5e-248 hypothetical protein TcasGA2_TC008324 [Tribolium castaneum] 332375782 BT128071.1 218 7.43028e-108 Dendroctonus ponderosae clone DPO116_B20 unknown mRNA K01892 HARS, hisS histidyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01892 Q61035 1637 1.0e-180 Histidine--tRNA ligase, cytoplasmic OS=Mus musculus GN=Hars PE=2 SV=2 PF05073//PF00458//PF00587//PF00152 Baculovirus P24 capsid protein//WHEP-TRS domain//tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N) GO:0006418 tRNA aminoacylation for protein translation GO:0000166//GO:0005524//GO:0004812 nucleotide binding//ATP binding//aminoacyl-tRNA ligase activity GO:0019028 viral capsid KOG1936 Histidyl-tRNA synthetase Cluster-8309.47515 BF_2 297.04 6.97 2069 646718490 KDR20930.1 993 9.6e-105 hypothetical protein L798_03868 [Zootermopsis nevadensis] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 D4A4K3 586 6.2e-59 Beclin 1-associated autophagy-related key regulator OS=Rattus norvegicus GN=Atg14 PE=3 SV=1 PF10186//PF00643 Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0010508 positive regulation of autophagy GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.47518 BF_2 94.60 2.52 1857 189233648 XP_972556.2 711 4.3e-72 PREDICTED: beta-arrestin-1 isoform X4 [Tribolium castaneum] 642910565 XM_967463.3 283 4.00799e-144 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X4, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P51485 395 7.8e-37 Probable beta-arrestin OS=Caenorhabditis elegans GN=arr-1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3865 Arrestin Cluster-8309.47519 BF_2 105.28 2.01 2481 642910564 XP_008200268.1 1299 3.8e-140 PREDICTED: arrestin red cell isoform 2 isoform X3 [Tribolium castaneum] 525343481 NM_001279418.1 174 2.10669e-83 Bombyx mori beta-arrestin-1-like (LOC101742650), mRNA >gnl|BL_ORD_ID|14275337 Bombyx mori strain Qiufeng x Baiyu nonvisual arrestin mRNA, complete cds K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 Q4R562 933 4.3e-99 Beta-arrestin-1 OS=Macaca fascicularis GN=ARRB1 PE=2 SV=1 PF00950 ABC 3 transport family GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016020 membrane KOG3865 Arrestin Cluster-8309.47521 BF_2 28.53 0.40 3290 642910562 XP_008200267.1 1299 5.0e-140 PREDICTED: arrestin red cell isoform 2 isoform X2 [Tribolium castaneum] 642910561 XM_008202045.1 274 7.20662e-139 PREDICTED: Tribolium castaneum kurtz (LOC661293), transcript variant X2, mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P49407 933 5.7e-99 Beta-arrestin-1 OS=Homo sapiens GN=ARRB1 PE=1 SV=2 PF00950 ABC 3 transport family GO:0006810 transport GO:0042626//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATP binding GO:0016020 membrane KOG3865 Arrestin Cluster-8309.47524 BF_2 51.95 0.89 2740 91079879 XP_975774.1 464 2.8e-43 PREDICTED: uncharacterized protein LOC655985 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04889 Cwf15/Cwc15 cell cycle control protein GO:0000398 mRNA splicing, via spliceosome -- -- GO:0005681 spliceosomal complex -- -- Cluster-8309.47526 BF_2 479.55 1.65 12418 642914032 XP_008201515.1 5554 0.0e+00 PREDICTED: syntaxin-binding protein 5 isoform X2 [Tribolium castaneum] 751777385 XM_011199394.1 86 8.84214e-34 PREDICTED: Bactrocera dorsalis probable ATP-dependent RNA helicase DDX10 (LOC105222182), mRNA K08518 STXBP5 syntaxin-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08518 Q9WU70 2011 2.1e-223 Syntaxin-binding protein 5 OS=Rattus norvegicus GN=Stxbp5 PE=1 SV=1 PF00957//PF00802//PF11616//PF04992//PF00400//PF11427//PF00270//PF01218 Synaptobrevin//Pneumovirus attachment glycoprotein G//WD repeat binding protein EZH2//RNA polymerase Rpb1, domain 6//WD domain, G-beta repeat//Tc3 transposase//DEAD/DEAH box helicase//Coproporphyrinogen III oxidase GO:0006351//GO:0015994//GO:0006144//GO:0006206//GO:0006479//GO:0016192//GO:0006554//GO:0006779//GO:0055114 transcription, DNA-templated//chlorophyll metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//protein methylation//vesicle-mediated transport//lysine catabolic process//porphyrin-containing compound biosynthetic process//oxidation-reduction process GO:0018024//GO:0003677//GO:0004109//GO:0005515//GO:0003676//GO:0005524//GO:0003899 histone-lysine N-methyltransferase activity//DNA binding//coproporphyrinogen oxidase activity//protein binding//nucleic acid binding//ATP binding//DNA-directed RNA polymerase activity GO:0016021//GO:0055036//GO:0005730 integral component of membrane//virion membrane//nucleolus KOG0343 RNA Helicase Cluster-8309.47527 BF_2 157.27 1.89 3766 642921579 XP_008192431.1 1018 2.2e-107 PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum]>gi|642921581|ref|XP_008192432.1| PREDICTED: MOB kinase activator-like 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2LZ59 873 5.9e-92 MOB kinase activator-like 2 OS=Drosophila pseudoobscura pseudoobscura GN=Mob1 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG0440 Cell cycle-associated protein Mob1-1 Cluster-8309.47528 BF_2 1039.42 12.45 3779 546673579 ERL85150.1 2312 2.0e-257 hypothetical protein D910_02572 [Dendroctonus ponderosae] 381143842 JN171289.1 206 5.24234e-101 Bembidion scopulinum voucher DRMaddison:DNA1282 topoisomerase I gene, partial cds K03163 TOP1 DNA topoisomerase I http://www.genome.jp/dbget-bin/www_bget?ko:K03163 P30189 1944 3.8e-216 DNA topoisomerase 1 OS=Drosophila melanogaster GN=Top1 PE=1 SV=1 PF02919//PF01028 Eukaryotic DNA topoisomerase I, DNA binding fragment//Eukaryotic DNA topoisomerase I, catalytic core GO:0006265 DNA topological change GO:0003917//GO:0003677//GO:0003918 DNA topoisomerase type I activity//DNA binding//DNA topoisomerase type II (ATP-hydrolyzing) activity GO:0005694 chromosome KOG0981 DNA topoisomerase I Cluster-8309.47531 BF_2 186.12 5.61 1675 270009029 EFA05477.1 800 1.9e-82 hypothetical protein TcasGA2_TC015661 [Tribolium castaneum] -- -- -- -- -- K10606 FANCL, PHF9 E3 ubiquitin-protein ligase FANCL http://www.genome.jp/dbget-bin/www_bget?ko:K10606 Q9NW38 346 3.4e-31 E3 ubiquitin-protein ligase FANCL OS=Homo sapiens GN=FANCL PE=1 SV=2 PF13639//PF12678//PF12906//PF12861//PF00628 Ring finger domain//RING-H2 zinc finger//RING-variant domain//Anaphase-promoting complex subunit 11 RING-H2 finger//PHD-finger GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0008270 ubiquitin-protein transferase activity//protein binding//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.47532 BF_2 41.00 0.48 3879 642930592 XP_008198268.1 295 1.6e-23 PREDICTED: calponin homology domain-containing protein DDB_G0272472 [Tribolium castaneum]>gi|270010755|gb|EFA07203.1| hypothetical protein TcasGA2_TC010210 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04610//PF06624 TrbL/VirB6 plasmid conjugal transfer protein//Ribosome associated membrane protein RAMP4 GO:0030255 protein secretion by the type IV secretion system -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-8309.47534 BF_2 31.99 0.65 2331 728417130 AIY68334.1 705 2.7e-71 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 316 1.4e-27 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.47535 BF_2 1033.82 26.36 1928 91080555 XP_967130.1 706 1.7e-71 PREDICTED: clathrin light chain isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWA1 368 1.1e-33 Clathrin light chain OS=Drosophila melanogaster GN=Clc PE=2 SV=1 PF01086//PF13855 Clathrin light chain//Leucine rich repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.47537 BF_2 21.46 0.41 2465 642919416 XP_008191861.1 399 8.7e-36 PREDICTED: F-box/LRR-repeat protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K04644 CLTA, LCA clathrin light chain A http://www.genome.jp/dbget-bin/www_bget?ko:K04644 Q8IY45 297 2.4e-25 Protein AMN1 homolog OS=Homo sapiens GN=AMN1 PE=2 SV=4 PF13855//PF01086 Leucine rich repeat//Clathrin light chain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030130//GO:0030132 clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit -- -- Cluster-8309.47538 BF_2 71.56 1.48 2314 642919416 XP_008191861.1 399 8.1e-36 PREDICTED: F-box/LRR-repeat protein 2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY45 297 2.2e-25 Protein AMN1 homolog OS=Homo sapiens GN=AMN1 PE=2 SV=4 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.47539 BF_2 238.00 3.49 3137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01708 Geminivirus putative movement protein GO:0046740 transport of virus in host, cell to cell -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47541 BF_2 30.15 0.39 3543 478254798 ENN75034.1 2058 5.3e-228 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 227 1.04089e-112 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 1138 1.0e-122 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF03526//PF06870//PF00887 Colicin E1 (microcin) immunity protein//A49-like RNA polymerase I associated factor//Acyl CoA binding protein GO:0006351//GO:0006144//GO:0006206//GO:0006955//GO:0030153 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//immune response//bacteriocin immunity GO:0000062//GO:0003899//GO:0003677//GO:0015643 fatty-acyl-CoA binding//DNA-directed RNA polymerase activity//DNA binding//toxic substance binding GO:0005634//GO:0019814//GO:0005730 nucleus//immunoglobulin complex//nucleolus KOG3530 FERM domain protein EHM2 Cluster-8309.47544 BF_2 335.24 7.42 2177 189236990 XP_970274.2 792 2.1e-81 PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|642921800|ref|XP_008199324.1| PREDICTED: uncharacterized protein LOC658824 [Tribolium castaneum]>gi|270008114|gb|EFA04562.1| hypothetical protein TcasGA2_TC010947 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZS10 145 8.9e-08 C-type lectin domain family 17, member A OS=Homo sapiens GN=CLEC17A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47545 BF_2 15.21 1.57 693 478260276 ENN80028.1 211 1.5e-14 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P17012 167 8.0e-11 Zinc finger X-chromosomal protein OS=Mus musculus GN=Zfx PE=1 SV=2 PF16622//PF00096//PF13465//PF04988//PF01096 zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//A-kinase anchoring protein 95 (AKAP95)//Transcription factor S-II (TFIIS) GO:0006351 transcription, DNA-templated GO:0003676//GO:0003677//GO:0008270//GO:0046872 nucleic acid binding//DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47547 BF_2 361.40 5.41 3080 642920934 XP_001814127.2 1388 2.3e-150 PREDICTED: yemanuclein-alpha isoform X2 [Tribolium castaneum] -- -- -- -- -- K17492 UBN ubinuclein http://www.genome.jp/dbget-bin/www_bget?ko:K17492 Q80WC1 453 2.4e-43 Ubinuclein-2 OS=Mus musculus GN=Ubn2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47548 BF_2 32.74 0.45 3299 91077726 XP_975075.1 2465 3.1e-275 PREDICTED: protein inturned [Tribolium castaneum]>gi|270002215|gb|EEZ98662.1| hypothetical protein TcasGA2_TC001193 [Tribolium castaneum] 642914358 XM_969982.2 79 1.81482e-30 PREDICTED: Tribolium castaneum protein inturned (LOC663956), mRNA -- -- -- -- Q2I0E5 577 1.1e-57 Protein inturned OS=Xenopus laevis GN=intu PE=2 SV=1 PF03276 Spumavirus gag protein GO:0019076//GO:0075521//GO:0046718 viral release from host cell//microtubule-dependent intracellular transport of viral material towards nucleus//viral entry into host cell -- -- GO:0030430//GO:0044163//GO:0042025//GO:0019028 host cell cytoplasm//host cytoskeleton//host cell nucleus//viral capsid -- -- Cluster-8309.47552 BF_2 49.85 1.29 1906 665789011 XP_008560125.1 1371 1.3e-148 PREDICTED: uncharacterized protein LOC103580223 [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00412//PF00751 LIM domain//DM DNA binding domain GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565 zinc ion binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.47553 BF_2 89.36 2.35 1878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47555 BF_2 230.45 2.16 4759 478259245 ENN79147.1 3080 0.0e+00 hypothetical protein YQE_04333, partial [Dendroctonus ponderosae] 260807434 XM_002598468.1 163 5.29776e-77 Branchiostoma floridae hypothetical protein, mRNA K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 2537 8.4e-285 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF07728//PF08752//PF01695//PF01926//PF06068//PF05496//PF00004//PF07724//PF07726//PF00005//PF01299//PF02367//PF01637//PF00910//PF06800 AAA domain (dynein-related subfamily)//Coatomer gamma subunit appendage platform subdomain//IstB-like ATP binding protein//50S ribosome-binding GTPase//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA)//ABC transporter//Lysosome-associated membrane glycoprotein (Lamp)//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Archaeal ATPase//RNA helicase//Sugar transport protein GO:0006886//GO:0006281//GO:0016192//GO:0034219//GO:0008643//GO:0006310//GO:0002949 intracellular protein transport//DNA repair//vesicle-mediated transport//carbohydrate transmembrane transport//carbohydrate transport//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0005198//GO:0015144//GO:0005524//GO:0016887//GO:0003723//GO:0003678//GO:0003724//GO:0009378//GO:0005525 structural molecule activity//carbohydrate transmembrane transporter activity//ATP binding//ATPase activity//RNA binding//DNA helicase activity//RNA helicase activity//four-way junction helicase activity//GTP binding GO:0009379//GO:0016021//GO:0030126//GO:0005657//GO:0016020 Holliday junction helicase complex//integral component of membrane//COPI vesicle coat//replication fork//membrane KOG0741 AAA+-type ATPase Cluster-8309.47556 BF_2 263.76 2.61 4521 642911937 XP_008199029.1 3664 0.0e+00 PREDICTED: arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1 [Tribolium castaneum] 642911942 XM_008200810.1 525 0 PREDICTED: Tribolium castaneum arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (LOC656708), transcript variant X4, mRNA K12488 ASAP Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12488 O97902 1725 1.1e-190 Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 OS=Bos taurus GN=ASAP1 PE=1 SV=1 PF14604//PF00023//PF00018//PF03114//PF07043//PF08397//PF13606//PF01412 Variant SH3 domain//Ankyrin repeat//SH3 domain//BAR domain//Protein of unknown function (DUF1328)//IRSp53/MIM homology domain//Ankyrin repeat//Putative GTPase activating protein for Arf GO:0007009 plasma membrane organization GO:0005096//GO:0005515 GTPase activator activity//protein binding GO:0005886//GO:0005737 plasma membrane//cytoplasm KOG0521 Putative GTPase activating proteins (GAPs) Cluster-8309.47559 BF_2 151.32 0.45 14374 189241098 XP_971301.2 11947 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13D [Tribolium castaneum] -- -- -- -- -- K19527 VPS13D vacuolar protein sorting-associated protein 13D http://www.genome.jp/dbget-bin/www_bget?ko:K19527 Q5THJ4 2017 5.0e-224 Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.4756 BF_2 4.42 0.36 800 642925206 XP_008194468.1 434 2.5e-40 PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum]>gi|642925208|ref|XP_008194469.1| PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum] -- -- -- -- -- K15153 MED31, SOH1 mediator of RNA polymerase II transcription subunit 31 http://www.genome.jp/dbget-bin/www_bget?ko:K15153 Q17DI7 357 8.6e-33 Mediator of RNA polymerase II transcription subunit 31 OS=Aedes aegypti GN=MED31 PE=3 SV=1 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4086 Transcriptional regulator SOH1 Cluster-8309.47567 BF_2 30.68 2.24 860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47568 BF_2 89.32 4.18 1181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4757 BF_2 35.04 3.19 747 642925206 XP_008194468.1 623 2.8e-62 PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum]>gi|642925208|ref|XP_008194469.1| PREDICTED: mediator of RNA polymerase II transcription subunit 31 [Tribolium castaneum] -- -- -- -- -- K15153 MED31, SOH1 mediator of RNA polymerase II transcription subunit 31 http://www.genome.jp/dbget-bin/www_bget?ko:K15153 Q28FE2 482 2.6e-47 Mediator of RNA polymerase II transcription subunit 31 OS=Xenopus tropicalis GN=med31 PE=2 SV=2 PF05669 SOH1 GO:0006355 regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4086 Transcriptional regulator SOH1 Cluster-8309.47571 BF_2 25.80 0.61 2058 478251301 ENN71769.1 758 1.7e-77 hypothetical protein YQE_11504, partial [Dendroctonus ponderosae] -- -- -- -- -- K01487 E3.5.4.3, guaD guanine deaminase http://www.genome.jp/dbget-bin/www_bget?ko:K01487 Q86AW9 481 9.2e-47 Guanine deaminase OS=Dictyostelium discoideum GN=guaD PE=1 SV=1 PF00962//PF01979 Adenosine/AMP deaminase//Amidohydrolase family -- -- GO:0019239//GO:0016787 deaminase activity//hydrolase activity -- -- KOG3968 Atrazine chlorohydrolase/guanine deaminase Cluster-8309.47573 BF_2 154.95 1.07 6323 642936157 XP_008198320.1 2712 1.4e-303 PREDICTED: transcription factor RFX3 isoform X2 [Tribolium castaneum] 620977287 XM_007670933.1 80 9.71757e-31 PREDICTED: Ornithorhynchus anatinus regulatory factor X, 2 (influences HLA class II expression) (RFX2), mRNA K09173 RFX1_2_3 regulatory factor X 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09173 Q0V9K5 1350 4.9e-147 Transcription factor RFX3 OS=Xenopus tropicalis GN=rfx3 PE=2 SV=2 PF02257 RFX DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG3712 RFX family transcription factor Cluster-8309.47575 BF_2 35.76 2.80 822 642915266 XP_971845.3 235 3.0e-17 PREDICTED: sorting nexin-16 [Tribolium castaneum]>gi|270003912|gb|EFA00360.1| hypothetical protein TcasGA2_TC003202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47577 BF_2 71.67 0.37 8394 123407101 XP_001302933.1 225 4.4e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.6e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47583 BF_2 11.68 0.55 1183 607356497 EZA51012.1 179 1.3e-10 hypothetical protein X777_10518, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09907 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.47584 BF_2 109.01 0.86 5584 546675238 ERL86474.1 1956 5.6e-216 hypothetical protein D910_03880 [Dendroctonus ponderosae] -- -- -- -- -- K01262 pepP Xaa-Pro aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01262 Q54G06 923 1.4e-97 Xaa-Pro aminopeptidase 1 OS=Dictyostelium discoideum GN=xpnpep1 PE=3 SV=1 PF02723//PF01398//PF04961//PF10278//PF01321 Non-structural protein NS3/Small envelope protein E//JAB1/Mov34/MPN/PAD-1 ubiquitin protease//Formiminotransferase-cyclodeaminase//Mediator of RNA pol II transcription subunit 19//Creatinase/Prolidase N-terminal domain GO:0006357//GO:0044237 regulation of transcription from RNA polymerase II promoter//cellular metabolic process GO:0005515//GO:0003824//GO:0001104//GO:0016787 protein binding//catalytic activity//RNA polymerase II transcription cofactor activity//hydrolase activity GO:0016020//GO:0016592 membrane//mediator complex KOG2413 Xaa-Pro aminopeptidase Cluster-8309.47587 BF_2 535.13 12.08 2140 759056049 XP_011337263.1 1712 4.2e-188 PREDICTED: septin-2 isoform X2 [Cerapachys biroi] 749756922 XM_011142606.1 276 3.60503e-140 PREDICTED: Harpegnathos saltator septin-2 (LOC105184061), mRNA K16939 SEPT6_8_11 septin 6/8/11 http://www.genome.jp/dbget-bin/www_bget?ko:K16939 P54359 1637 8.6e-181 Septin-2 OS=Drosophila melanogaster GN=Sep2 PE=2 SV=2 PF07926//PF04799//PF03193//PF13897//PF00071//PF02601//PF00735//PF08477//PF04111//PF01926//PF10186//PF06367 TPR/MLP1/MLP2-like protein//fzo-like conserved region//Protein of unknown function, DUF258//Golgi-dynamics membrane-trafficking//Ras family//Exonuclease VII, large subunit//Septin//Ras of Complex, Roc, domain of DAPkinase//Autophagy protein Apg6//50S ribosome-binding GTPase//Vacuolar sorting 38 and autophagy-related subunit 14//Diaphanous FH3 Domain GO:0006308//GO:0010508//GO:0007264//GO:0006606//GO:0008053//GO:0006810//GO:0016043//GO:0006914 DNA catabolic process//positive regulation of autophagy//small GTPase mediated signal transduction//protein import into nucleus//mitochondrial fusion//transport//cellular component organization//autophagy GO:0005525//GO:0003924//GO:0003779//GO:0008855 GTP binding//GTPase activity//actin binding//exodeoxyribonuclease VII activity GO:0005741//GO:0009318//GO:0016021 mitochondrial outer membrane//exodeoxyribonuclease VII complex//integral component of membrane KOG3859 Septins (P-loop GTPases) Cluster-8309.47589 BF_2 553.00 27.38 1132 270002223 EEZ98670.1 642 2.6e-64 hypothetical protein TcasGA2_TC001202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UPR3 132 1.5e-06 Protein SMG5 OS=Homo sapiens GN=SMG5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47591 BF_2 426.06 6.22 3151 91086463 XP_969857.1 1953 7.0e-216 PREDICTED: putative ferric-chelate reductase 1 homolog [Tribolium castaneum]>gi|270009811|gb|EFA06259.1| hypothetical protein TcasGA2_TC009118 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MSU3 1236 4.0e-134 Putative ferric-chelate reductase 1 homolog OS=Drosophila melanogaster GN=CG8399 PE=2 SV=1 PF03188//PF00335 Eukaryotic cytochrome b561//Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4293 Predicted membrane protein, contains DoH and Cytochrome b-561/ferric reductase transmembrane domains Cluster-8309.47592 BF_2 2.00 0.92 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47593 BF_2 270.06 1.40 8381 91083409 XP_968752.1 1012 2.4e-106 PREDICTED: sodium/potassium/calcium exchanger 4 [Tribolium castaneum]>gi|270006894|gb|EFA03342.1| hypothetical protein TcasGA2_TC013319 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q8NFF2 545 1.4e-53 Sodium/potassium/calcium exchanger 4 OS=Homo sapiens GN=SLC24A4 PE=1 SV=2 PF06689//PF01699 ClpX C4-type zinc finger//Sodium/calcium exchanger protein GO:0055085 transmembrane transport GO:0046983//GO:0008270 protein dimerization activity//zinc ion binding GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.47594 BF_2 48.42 2.92 982 91083409 XP_968752.1 914 6.6e-96 PREDICTED: sodium/potassium/calcium exchanger 4 [Tribolium castaneum]>gi|270006894|gb|EFA03342.1| hypothetical protein TcasGA2_TC013319 [Tribolium castaneum] -- -- -- -- -- K13752 SLC24A4, NCKX4 solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13752 Q8NFF2 567 4.7e-57 Sodium/potassium/calcium exchanger 4 OS=Homo sapiens GN=SLC24A4 PE=1 SV=2 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.47602 BF_2 479.53 4.68 4578 642932649 XP_969929.2 1010 2.3e-106 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 705 2.2e-72 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.47603 BF_2 462.28 4.09 5018 642932649 XP_969929.2 1247 8.2e-134 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 886 2.5e-93 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.47605 BF_2 271.55 6.68 1987 642921483 XP_008192888.1 1043 1.5e-110 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY1 209 3.1e-15 Monocarboxylate transporter 9 OS=Homo sapiens GN=SLC16A9 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.47607 BF_2 403.73 4.84 3774 91091546 XP_970948.1 1001 2.1e-105 PREDICTED: myb-like protein X [Tribolium castaneum]>gi|642936928|ref|XP_008194494.1| PREDICTED: myb-like protein X [Tribolium castaneum]>gi|270000921|gb|EEZ97368.1| hypothetical protein TcasGA2_TC011190 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96MX3 167 4.4e-10 Zinc finger protein 48 OS=Homo sapiens GN=ZNF48 PE=1 SV=2 PF13912//PF00096//PF02178 C2H2-type zinc finger//Zinc finger, C2H2 type//AT hook motif -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding -- -- -- -- Cluster-8309.47609 BF_2 337.11 7.29 2222 642916163 XP_008190912.1 2033 2.6e-225 PREDICTED: abhydrolase domain-containing protein 16A [Tribolium castaneum]>gi|270003703|gb|EFA00151.1| hypothetical protein TcasGA2_TC002972 [Tribolium castaneum] 658893399 XM_008431335.1 63 9.5401e-22 PREDICTED: Poecilia reticulata abhydrolase domain containing 16A (abhd16a), transcript variant X2, mRNA -- -- -- -- Q5R6S0 1171 9.7e-127 Abhydrolase domain-containing protein 16A OS=Pongo abelii GN=ABHD16A PE=2 SV=1 PF00326 Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- KOG1553 Predicted alpha/beta hydrolase BAT5 Cluster-8309.47610 BF_2 27.82 0.68 1987 478257813 ENN77956.1 1787 7.9e-197 hypothetical protein YQE_05633, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46040 325 1.1e-28 Protein msta, isoform A OS=Drosophila melanogaster GN=msta PE=2 SV=3 PF00856 SET domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47611 BF_2 214.72 4.44 2312 189235087 XP_001808767.1 2027 1.4e-224 PREDICTED: leucine-rich repeat-containing protein 16A [Tribolium castaneum] 642915512 XM_008192426.1 123 4.39795e-55 PREDICTED: Tribolium castaneum adenylate kinase isoenzyme 6 (LOC103312254), mRNA -- -- -- -- Q5VZK9 887 8.7e-94 Leucine-rich repeat-containing protein 16A OS=Homo sapiens GN=LRRC16A PE=1 SV=1 PF01121//PF00560//PF00005//PF03193//PF03266//PF00910//PF10662//PF00493//PF13516//PF01443//PF14532//PF02224//PF01580//PF01926//PF00158//PF01695//PF07728//PF00004//PF13855 Dephospho-CoA kinase//Leucine Rich Repeat//ABC transporter//Protein of unknown function, DUF258//NTPase//RNA helicase//Ethanolamine utilisation - propanediol utilisation//MCM2/3/5 family//Leucine Rich repeat//Viral (Superfamily 1) RNA helicase//Sigma-54 interaction domain//Cytidylate kinase//FtsK/SpoIIIE family//50S ribosome-binding GTPase//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Leucine rich repeat GO:0015937//GO:0006260//GO:0006355//GO:0006139//GO:0015940//GO:0006206//GO:0006576 coenzyme A biosynthetic process//DNA replication//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process//pantothenate biosynthetic process//pyrimidine nucleobase metabolic process//cellular biogenic amine metabolic process GO:0004127//GO:0016887//GO:0000166//GO:0008134//GO:0003924//GO:0098519//GO:0005524//GO:0003724//GO:0004140//GO:0005525//GO:0005515//GO:0003677//GO:0003723 cytidylate kinase activity//ATPase activity//nucleotide binding//transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//RNA helicase activity//dephospho-CoA kinase activity//GTP binding//protein binding//DNA binding//RNA binding GO:0005667 transcription factor complex KOG3347 Predicted nucleotide kinase/nuclear protein involved oxidative stress response Cluster-8309.47612 BF_2 77.88 0.79 4401 642923551 XP_008193555.1 837 2.5e-86 PREDICTED: Golgi integral membrane protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08D19 143 3.1e-07 Golgi integral membrane protein 4 OS=Xenopus tropicalis GN=golim4 PE=2 SV=2 PF05090//PF02566//PF04111//PF02513//PF01940 Vitamin K-dependent gamma-carboxylase//OsmC-like protein//Autophagy protein Apg6//Spin/Ssty Family//Integral membrane protein DUF92 GO:0006914//GO:0007276//GO:0017187//GO:0006979 autophagy//gamete generation//peptidyl-glutamic acid carboxylation//response to oxidative stress GO:0008488 gamma-glutamyl carboxylase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47614 BF_2 63.34 1.24 2424 91081067 XP_975439.1 1963 3.8e-217 PREDICTED: uncharacterized protein ZC262.3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q50L44 311 5.6e-27 Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 OS=Gallus gallus GN=LINGO1 PE=2 SV=1 PF00560//PF13855//PF13895 Leucine Rich Repeat//Leucine rich repeat//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47620 BF_2 36.07 0.50 3286 332375725 AEE63003.1 548 6.1e-53 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0007178//GO:0016310//GO:0009069//GO:1903818//GO:0030431//GO:0032222 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic GO:0034235//GO:0004675 GPI anchor binding//transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.47622 BF_2 4.00 0.31 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47624 BF_2 56.52 0.75 3438 642917000 XP_008199589.1 241 2.5e-17 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47627 BF_2 63.49 0.85 3427 642917000 XP_008199589.1 241 2.5e-17 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47628 BF_2 170.23 3.53 2303 642917000 XP_008199589.1 631 1.0e-62 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 252 3.7e-20 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47630 BF_2 114.79 1.67 3156 189237912 XP_969631.2 2893 0.0e+00 PREDICTED: histone acetyltransferase KAT2A [Tribolium castaneum]>gi|270008022|gb|EFA04470.1| hypothetical protein TcasGA2_TC014774 [Tribolium castaneum] -- -- -- -- -- K06062 PCAF, KAT2, GCN5 histone acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06062 Q9JHD2 1837 8.2e-204 Histone acetyltransferase KAT2A OS=Mus musculus GN=Kat2a PE=1 SV=2 PF13673//PF00583//PF06472//PF13508//PF00439//PF06466 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//ABC transporter transmembrane region 2//Acetyltransferase (GNAT) domain//Bromodomain//PCAF (P300/CBP-associated factor) N-terminal domain GO:0016573//GO:0055085//GO:0042967//GO:0006810//GO:0006355 histone acetylation//transmembrane transport//acyl-carrier-protein biosynthetic process//transport//regulation of transcription, DNA-templated GO:0005524//GO:0008080//GO:0004402//GO:0005515//GO:0042626 ATP binding//N-acetyltransferase activity//histone acetyltransferase activity//protein binding//ATPase activity, coupled to transmembrane movement of substances GO:0005634//GO:0016021//GO:0000123 nucleus//integral component of membrane//histone acetyltransferase complex KOG1472 Histone acetyltransferase SAGA/ADA, catalytic subunit PCAF/GCN5 and related proteins Cluster-8309.47633 BF_2 629.00 32.37 1100 91091038 XP_975208.1 276 7.1e-22 PREDICTED: uncharacterized protein LOC664098 [Tribolium castaneum]>gi|270013164|gb|EFA09612.1| hypothetical protein TcasGA2_TC011733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03846//PF04442 Cell division inhibitor SulA//Cytochrome c oxidase assembly protein CtaG/Cox11 GO:0009432//GO:0051782 SOS response//negative regulation of cell division GO:0005507 copper ion binding GO:0009276 Gram-negative-bacterium-type cell wall -- -- Cluster-8309.47635 BF_2 551.66 15.41 1785 642913859 XP_008201191.1 617 3.3e-61 PREDICTED: uncharacterized protein LOC103315111 [Tribolium castaneum] 746845580 XM_011054780.1 39 1.67598e-08 PREDICTED: Acromyrmex echinatior protein spaetzle (LOC105145317), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47639 BF_2 218.25 10.00 1200 642923192 XP_008193649.1 667 3.5e-67 PREDICTED: MFS-type transporter SLC18B1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D3Z5L6 293 3.4e-25 MFS-type transporter SLC18B1 OS=Mus musculus GN=Slc18b1 PE=2 SV=2 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47640 BF_2 221.06 2.17 4544 642922737 XP_008193304.1 1814 1.3e-199 PREDICTED: protein RRP5 homolog [Tribolium castaneum] -- -- -- -- -- K14792 RRP5, PDCD11 rRNA biogenesis protein RRP5 http://www.genome.jp/dbget-bin/www_bget?ko:K14792 Q14690 642 4.4e-65 Protein RRP5 homolog OS=Homo sapiens GN=PDCD11 PE=1 SV=3 PF00575//PF05843//PF01496 S1 RNA binding domain//Suppressor of forked protein (Suf)//V-type ATPase 116kDa subunit family GO:0006397//GO:0015991//GO:0015992 mRNA processing//ATP hydrolysis coupled proton transport//proton transport GO:0015078//GO:0003676 hydrogen ion transmembrane transporter activity//nucleic acid binding GO:0005634//GO:0033179 nucleus//proton-transporting V-type ATPase, V0 domain KOG1070 rRNA processing protein Rrp5 Cluster-8309.47641 BF_2 104.82 1.46 3296 289474530 ADC97876.1 1920 4.9e-212 glycoside hydrolase family 31 [Chrysomela tremula] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 891 4.2e-94 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1065 Maltase glucoamylase and related hydrolases, glycosyl hydrolase family 31 Cluster-8309.47642 BF_2 61.64 0.88 3202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47644 BF_2 401.24 7.06 2665 546684067 ERL93790.1 2182 1.7e-242 hypothetical protein D910_11076 [Dendroctonus ponderosae] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 1363 6.4e-149 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.47645 BF_2 5.02 0.46 741 91080563 XP_973259.1 262 2.0e-20 PREDICTED: alpha-N-acetylglucosaminidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 152 4.7e-09 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.47646 BF_2 8.12 0.70 771 91090686 XP_974615.1 180 6.7e-11 PREDICTED: FGGY carbohydrate kinase domain-containing protein [Tribolium castaneum]>gi|270013302|gb|EFA09750.1| hypothetical protein TcasGA2_TC011889 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCD1 147 1.9e-08 FGGY carbohydrate kinase domain-containing protein OS=Xenopus laevis GN=fggy PE=2 SV=2 PF00370 FGGY family of carbohydrate kinases, N-terminal domain GO:0005975 carbohydrate metabolic process GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2517 Ribulose kinase and related carbohydrate kinases Cluster-8309.47650 BF_2 295.88 1.64 7822 817087620 XP_012266596.1 1741 6.7e-191 PREDICTED: uncharacterized protein LOC105692156 isoform X1 [Athalia rosae] 780665329 XM_011695591.1 124 4.17808e-55 PREDICTED: Wasmannia auropunctata uncharacterized LOC105453540 (LOC105453540), mRNA -- -- -- -- Q3ZCX4 649 1.2e-65 Zinc finger protein 568 OS=Homo sapiens GN=ZNF568 PE=2 SV=2 PF08064//PF13465//PF08880//PF00096 UME (NUC010) domain//Zinc-finger double domain//QLQ//Zinc finger, C2H2 type GO:0006355//GO:0016310//GO:0009069 regulation of transcription, DNA-templated//phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004674//GO:0046872 ATP binding//protein serine/threonine kinase activity//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.47652 BF_2 445.89 7.07 2924 189237332 XP_973384.2 1523 4.8e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 9.73578e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.4e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.47654 BF_2 37.55 0.34 4896 642927083 XP_008195130.1 5360 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927082 XM_008196908.1 520 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X1, mRNA -- -- -- -- Q9ULI1 411 2.9e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF07728//PF03193//PF00005//PF01637//PF00004//PF00931//PF00910 AAA domain (dynein-related subfamily)//Protein of unknown function, DUF258//ABC transporter//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//NB-ARC domain//RNA helicase -- -- GO:0005525//GO:0005524//GO:0003723//GO:0016887//GO:0043531//GO:0003724//GO:0003924 GTP binding//ATP binding//RNA binding//ATPase activity//ADP binding//RNA helicase activity//GTPase activity -- -- -- -- Cluster-8309.47656 BF_2 138.86 1.18 5197 642938278 XP_008192712.1 3280 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 959 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.1e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF07714//PF00069//PF12142 Protein tyrosine kinase//Protein kinase domain//Polyphenol oxidase middle domain GO:0006570//GO:0006468//GO:0055114//GO:0006118 tyrosine metabolic process//protein phosphorylation//oxidation-reduction process//obsolete electron transport GO:0004097//GO:0004672//GO:0005524 catechol oxidase activity//protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.47657 BF_2 61.99 0.67 4185 642938278 XP_008192712.1 3056 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938277 XM_008194490.1 871 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X2, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 Q9UKI8 1731 2.1e-191 Serine/threonine-protein kinase tousled-like 1 OS=Homo sapiens GN=TLK1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1151 Tousled-like protein kinase Cluster-8309.47660 BF_2 32.96 0.33 4437 642933795 XP_008197323.1 2058 6.6e-228 PREDICTED: multidrug resistance-associated protein 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q5F364 1283 2.0e-139 Multidrug resistance-associated protein 1 OS=Gallus gallus GN=ABCC1 PE=2 SV=1 PF03193//PF00005//PF17001//PF09547//PF06414//PF01637//PF08603//PF13304//PF01926//PF00664 Protein of unknown function, DUF258//ABC transporter//Type III secretion basal body protein I, YscI, HrpB, PscI//Stage IV sporulation protein A (spore_IV_A)//Zeta toxin//Archaeal ATPase//Adenylate cyclase associated (CAP) C terminal//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//ABC transporter transmembrane region GO:0009306//GO:0006810//GO:0007010//GO:0055085//GO:0043934 protein secretion//transport//cytoskeleton organization//transmembrane transport//sporulation GO:0003924//GO:0003779//GO:0005524//GO:0042626//GO:0005525//GO:0016887//GO:0016301 GTPase activity//actin binding//ATP binding//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//kinase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47661 BF_2 89.12 0.70 5636 373159263 AEY63781.1 2018 3.7e-223 ecdysone receptor isoform B [Monochamus alternatus] 373159262 JN616375.1 1054 0 Monochamus alternatus ecdysone receptor isoform B mRNA, complete cds K14034 NR1H1, EcR ecdysone receptor http://www.genome.jp/dbget-bin/www_bget?ko:K14034 P49880 1317 2.9e-143 Ecdysone receptor OS=Aedes aegypti GN=EcR PE=1 SV=2 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.47663 BF_2 330.00 185.13 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47664 BF_2 188.00 21.26 657 -- -- -- -- -- 642937526 XM_008200861.1 81 2.6803e-32 PREDICTED: Tribolium castaneum heterogeneous nuclear ribonucleoprotein 27C (LOC655156), transcript variant X7, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47665 BF_2 345.00 12.64 1429 570341954 AHE77375.1 542 1.3e-52 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P82147 340 1.4e-30 Protein lethal(2)essential for life OS=Drosophila melanogaster GN=l(2)efl PE=1 SV=1 PF00525 Alpha crystallin A chain, N terminal GO:0007423 sensory organ development GO:0005212 structural constituent of eye lens -- -- -- -- Cluster-8309.47666 BF_2 438.00 3.73 5196 189233955 XP_967484.2 2432 3.3e-271 PREDICTED: uncharacterized protein LOC655828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane -- -- Cluster-8309.47668 BF_2 49.96 0.64 3567 815897996 XP_012249713.1 1473 3.6e-160 PREDICTED: histone deacetylase 6 [Bombus impatiens] -- -- -- -- -- K11407 HDAC6 histone deacetylase 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11407 Q9Z2V5 1042 1.4e-111 Histone deacetylase 6 OS=Mus musculus GN=Hdac6 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1343 Histone deacetylase complex, catalytic component HDA1 Cluster-8309.47672 BF_2 1039.92 19.81 2483 642926071 XP_008194753.1 2757 3.3e-309 PREDICTED: transcription elongation factor SPT5 [Tribolium castaneum]>gi|270008998|gb|EFA05446.1| hypothetical protein TcasGA2_TC015626 [Tribolium castaneum] 158293810 XM_001231044.2 314 3.15053e-161 Anopheles gambiae str. PEST AGAP005021-PA (AgaP_AGAP005021) mRNA, complete cds K15172 SUPT5H, SPT5 transcription elongation factor SPT5 http://www.genome.jp/dbget-bin/www_bget?ko:K15172 Q9V460 2232 1.0e-249 Transcription elongation factor SPT5 OS=Drosophila melanogaster GN=Spt5 PE=1 SV=1 -- -- GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter -- -- -- -- KOG1999 RNA polymerase II transcription elongation factor DSIF/SUPT5H/SPT5 Cluster-8309.47676 BF_2 64.92 0.48 5998 546680189 ERL90517.1 1703 1.3e-186 hypothetical protein D910_07865 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54G05 523 3.6e-51 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF05440 Tetrahydromethanopterin S-methyltransferase subunit B GO:0046656//GO:0015948 folic acid biosynthetic process//methanogenesis GO:0030269 tetrahydromethanopterin S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.47679 BF_2 11.91 1.15 722 642912738 XP_966526.2 300 7.6e-25 PREDICTED: uncharacterized protein LOC654964 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 234 1.4e-18 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF02798//PF13417//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47680 BF_2 415.00 4.67 4008 189238846 XP_971101.2 2032 6.2e-225 PREDICTED: XK-related protein 7 [Tribolium castaneum]>gi|270010171|gb|EFA06619.1| hypothetical protein TcasGA2_TC009537 [Tribolium castaneum] -- -- -- -- -- K11583 PPP2R3 serine/threonine-protein phosphatase 2A regulatory subunit B'' http://www.genome.jp/dbget-bin/www_bget?ko:K11583 Q803V3 1320 9.3e-144 Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma OS=Danio rerio GN=ppp2r3c PE=2 SV=1 PF09815//PF13499//PF00036//PF13405 XK-related protein//EF-hand domain pair//EF hand//EF-hand domain -- -- GO:0005509 calcium ion binding GO:0016021 integral component of membrane KOG2562 Protein phosphatase 2 regulatory subunit Cluster-8309.47684 BF_2 289.43 2.73 4727 478260301 ENN80053.1 3354 0.0e+00 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1901 4.7e-211 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF04851//PF04408//PF02562//PF00437//PF00270//PF07652 Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//PhoH-like protein//Type II/IV secretion system protein//DEAD/DEAH box helicase//Flavivirus DEAD domain GO:0006810//GO:0019079 transport//viral genome replication GO:0008026//GO:0004386//GO:0005524//GO:0003677//GO:0016787//GO:0003676 ATP-dependent helicase activity//helicase activity//ATP binding//DNA binding//hydrolase activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.47685 BF_2 62.11 0.45 6065 478260301 ENN80053.1 2656 4.1e-297 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1477 8.7e-162 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF00437//PF07652//PF00270//PF04408//PF02562//PF04851 Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase//Helicase associated domain (HA2)//PhoH-like protein//Type III restriction enzyme, res subunit GO:0019079//GO:0006810 viral genome replication//transport GO:0016787//GO:0003677//GO:0004386//GO:0005524//GO:0008026//GO:0003676 hydrolase activity//DNA binding//helicase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.47687 BF_2 84.44 1.44 2737 642924813 XP_008194051.1 1176 7.7e-126 PREDICTED: nuclear receptor coactivator 7 isoform X3 [Tribolium castaneum] 749755570 XM_011141969.1 132 5.17849e-60 PREDICTED: Harpegnathos saltator oxidation resistance protein 1 (LOC105183677), transcript variant X5, mRNA -- -- -- -- Q6DFV7 539 2.3e-53 Nuclear receptor coactivator 7 OS=Mus musculus GN=Ncoa7 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2372 Oxidation resistance protein Cluster-8309.47688 BF_2 35.07 0.45 3565 546680054 ERL90409.1 2899 0.0e+00 hypothetical protein D910_07758, partial [Dendroctonus ponderosae] -- -- -- -- -- K13146 INTS9 integrator complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13146 Q8K114 1741 1.3e-192 Integrator complex subunit 9 OS=Mus musculus GN=Ints9 PE=2 SV=1 PF01896//PF00076 Eukaryotic and archaeal DNA primase small subunit//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896//GO:0003676 DNA primase activity//nucleic acid binding GO:0005730//GO:0005657 nucleolus//replication fork KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.47691 BF_2 484.00 2.79 7550 270003693 EFA00141.1 4947 0.0e+00 hypothetical protein TcasGA2_TC002962 [Tribolium castaneum] 642915996 XM_008192627.1 748 0 PREDICTED: Tribolium castaneum nuclear anchorage protein 1-like (LOC662729), mRNA -- -- -- -- O01761 501 1.6e-48 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF13895//PF02474//PF02554//PF01184 Immunoglobulin domain//Nodulation protein A (NodA)//Carbon starvation protein CstA//GPR1/FUN34/yaaH family GO:0009267//GO:0009877 cellular response to starvation//nodulation GO:0016746//GO:0005515 transferase activity, transferring acyl groups//protein binding GO:0005829//GO:0016021//GO:0016020 cytosol//integral component of membrane//membrane KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.47696 BF_2 92.00 0.65 6167 642910377 XP_971554.2 5768 0.0e+00 PREDICTED: uncharacterized protein LOC660207 isoform X3 [Tribolium castaneum] 194747504 XM_001956156.1 230 3.9112e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q0V8T7 600 4.4e-60 Contactin-associated protein like 5-3 OS=Mus musculus GN=Cntnap5c PE=2 SV=1 PF10192//PF00008 Rhodopsin-like GPCR transmembrane domain//EGF-like domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0005515 protein binding -- -- -- -- Cluster-8309.47697 BF_2 49.86 0.33 6642 478250040 ENN70546.1 5690 0.0e+00 hypothetical protein YQE_12721, partial [Dendroctonus ponderosae] 194747504 XM_001956156.1 230 4.21226e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q0V8T7 600 4.7e-60 Contactin-associated protein like 5-3 OS=Mus musculus GN=Cntnap5c PE=2 SV=1 PF00008//PF10192 EGF-like domain//Rhodopsin-like GPCR transmembrane domain GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone GO:0005515 protein binding -- -- -- -- Cluster-8309.47699 BF_2 530.00 9.20 2696 -- -- -- -- -- 642928667 XM_008201507.1 93 2.44085e-38 PREDICTED: Tribolium castaneum protein daughterless (LOC662057), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47701 BF_2 22.58 0.32 3217 642935257 XP_008197935.1 595 2.1e-58 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q99808 205 1.5e-14 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733//PF04893 Nucleoside transporter//Yip1 domain GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47702 BF_2 331.65 13.95 1282 642935257 XP_008197935.1 1324 2.5e-143 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 A1A4N1 372 2.5e-34 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47703 BF_2 398.42 5.64 3243 642935257 XP_008197935.1 595 2.1e-58 PREDICTED: NADPH-dependent diflavin oxidoreductase 1 [Tribolium castaneum] -- -- -- -- -- K15014 SLC29A1_2_3, ENT1_2_3 solute carrier family 29 (equilibrative nucleoside transporter), member 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15014 Q99808 205 1.5e-14 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733//PF04893 Nucleoside transporter//Yip1 domain GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.47706 BF_2 389.00 19.38 1127 642911168 XP_008200609.1 488 1.9e-46 PREDICTED: leucine-rich repeat-containing protein 70-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 199 2.5e-14 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47708 BF_2 24.82 0.46 2539 642931526 XP_008196622.1 666 9.8e-67 PREDICTED: 227 kDa spindle- and centromere-associated protein isoform X1 [Tribolium castaneum] 462342680 APGK01035633.1 36 1.11572e-06 Dendroctonus ponderosae Seq01035643, whole genome shotgun sequence -- -- -- -- Q7SXT7 291 1.2e-24 Zinc finger C2HC domain-containing protein 1A OS=Danio rerio GN=zc2hc1a PE=2 SV=1 PF00096//PF04690//PF15168 Zinc finger, C2H2 type//YABBY protein//Triple QxxK/R motif-containing protein family GO:0007275 multicellular organismal development GO:0046872 metal ion binding GO:0005789 endoplasmic reticulum membrane KOG3940 Uncharacterized conserved protein Cluster-8309.47712 BF_2 924.77 7.55 5412 189238580 XP_971286.2 2127 8.1e-236 PREDICTED: protein mothers against dpp-like [Tribolium castaneum] 826414663 XM_012666571.1 155 1.68853e-72 PREDICTED: Monomorium pharaonis protein mothers against dpp (LOC105828307), transcript variant X2, mRNA K04676 SMAD1 mothers against decapentaplegic homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04676 P42003 1912 2.8e-212 Protein mothers against dpp OS=Drosophila melanogaster GN=Mad PE=1 SV=1 PF01272//PF03165//PF10401//PF03166 Transcription elongation factor, GreA/GreB, C-term//MH1 domain//Interferon-regulatory factor 3//MH2 domain GO:0006355//GO:0032784 regulation of transcription, DNA-templated//regulation of DNA-templated transcription, elongation GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.47713 BF_2 51.87 0.48 4837 91084075 XP_967986.1 1341 1.0e-144 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I923 524 2.2e-51 Regucalcin OS=Gallus gallus GN=RGN PE=2 SV=1 -- -- GO:0050790 regulation of catalytic activity GO:0030234//GO:0005509 enzyme regulator activity//calcium ion binding -- -- -- -- Cluster-8309.47714 BF_2 443.41 6.64 3082 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01853 MOZ/SAS family GO:0006355 regulation of transcription, DNA-templated GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.47716 BF_2 43.51 2.92 911 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47717 BF_2 61.08 0.93 3022 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01853//PF05428 MOZ/SAS family//Corticotropin-releasing factor binding protein (CRF-BP) GO:0006355 regulation of transcription, DNA-templated GO:0016747//GO:0051424 transferase activity, transferring acyl groups other than amino-acyl groups//corticotropin-releasing hormone binding -- -- -- -- Cluster-8309.47718 BF_2 313.08 1.91 7132 91087949 XP_972541.1 1210 2.3e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.1e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF12763//PF13606//PF13405//PF10591//PF13833//PF13499//PF13202//PF01694//PF00036//PF00023 Cytoskeletal-regulatory complex EF hand//Ankyrin repeat//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain pair//EF hand//Rhomboid family//EF hand//Ankyrin repeat GO:0007165 signal transduction GO:0005509//GO:0004252//GO:0005515 calcium ion binding//serine-type endopeptidase activity//protein binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.47719 BF_2 458.01 2.88 6939 91087949 XP_972541.1 1210 2.2e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.1e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF13606//PF13833//PF10591//PF13405//PF13499//PF12763//PF00036//PF00023//PF13202//PF01694 Ankyrin repeat//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//EF hand//Ankyrin repeat//EF hand//Rhomboid family GO:0007165 signal transduction GO:0004252//GO:0005515//GO:0005509 serine-type endopeptidase activity//protein binding//calcium ion binding GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.4772 BF_2 5.79 0.63 669 270004758 EFA01206.1 190 4.0e-12 hypothetical protein TcasGA2_TC010533 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15050//PF00060 SCIMP protein//Ligand-gated ion channel GO:0006811//GO:0007165//GO:0007268 ion transport//signal transduction//synaptic transmission GO:0004970 ionotropic glutamate receptor activity GO:0016020//GO:0016021//GO:0001772//GO:0097197 membrane//integral component of membrane//immunological synapse//tetraspanin-enriched microdomain -- -- Cluster-8309.47723 BF_2 78.60 20.91 444 91077988 XP_968808.1 167 1.2e-09 PREDICTED: protein SERAC1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47727 BF_2 371.77 2.05 7876 91093773 XP_966763.1 1569 5.9e-171 PREDICTED: KAT8 regulatory NSL complex subunit 1 [Tribolium castaneum]>gi|270015922|gb|EFA12370.1| hypothetical protein TcasGA2_TC002076 [Tribolium castaneum] 462418059 APGK01017125.1 89 1.20329e-35 Dendroctonus ponderosae Seq01017135, whole genome shotgun sequence K18400 KANSL1 KAT8 regulatory NSL complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18400 Q7Z3B3 343 3.6e-30 KAT8 regulatory NSL complex subunit 1 OS=Homo sapiens GN=KANSL1 PE=1 SV=2 PF06009//PF14822//PF08651//PF17064 Laminin Domain II//Vasohibin//DASH complex subunit Duo1//Sleepless protein GO:0032222//GO:0007155//GO:0007067//GO:0045765//GO:0030431//GO:1903818 regulation of synaptic transmission, cholinergic//cell adhesion//mitotic nuclear division//regulation of angiogenesis//sleep//positive regulation of voltage-gated potassium channel activity GO:0034235 GPI anchor binding GO:0042729//GO:0005737//GO:0072686 DASH complex//cytoplasm//mitotic spindle -- -- Cluster-8309.47729 BF_2 146.83 6.17 1283 478252069 ENN72500.1 875 2.9e-91 hypothetical protein YQE_10841, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O14929 434 1.6e-41 Histone acetyltransferase type B catalytic subunit OS=Homo sapiens GN=HAT1 PE=1 SV=1 PF10394//PF06580//PF13508//PF05301//PF00583//PF13673//PF08445 Histone acetyl transferase HAT1 N-terminus//Histidine kinase//Acetyltransferase (GNAT) domain//Touch receptor neuron protein Mec-17//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967//GO:0016310//GO:0016568//GO:0000160//GO:0071929 acyl-carrier-protein biosynthetic process//phosphorylation//chromatin modification//phosphorelay signal transduction system//alpha-tubulin acetylation GO:0008080//GO:0004402//GO:0000155//GO:0016747//GO:0019799 N-acetyltransferase activity//histone acetyltransferase activity//phosphorelay sensor kinase activity//transferase activity, transferring acyl groups other than amino-acyl groups//tubulin N-acetyltransferase activity GO:0005874//GO:0009365//GO:0045298//GO:0016021//GO:0000123 microtubule//protein histidine kinase complex//tubulin complex//integral component of membrane//histone acetyltransferase complex KOG2696 Histone acetyltransferase type b catalytic subunit Cluster-8309.47731 BF_2 249.32 9.59 1375 642918845 XP_008191611.1 681 9.7e-69 PREDICTED: phosphoglycolate phosphatase 2-like [Tribolium castaneum]>gi|270005689|gb|EFA02137.1| hypothetical protein TcasGA2_TC007787 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 314 1.4e-27 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 PF02310 B12 binding domain -- -- GO:0046872//GO:0031419 metal ion binding//cobalamin binding -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.47732 BF_2 105.60 5.16 1144 642927612 XP_973436.3 625 2.5e-62 PREDICTED: cell growth regulator with RING finger domain protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47733 BF_2 1048.52 10.01 4669 283046724 NP_001164308.1 1952 1.4e-215 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 751 1.0e-77 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF00520//PF08727//PF13606//PF00023 Ion transport protein//Poliovirus 3A protein like//Ankyrin repeat//Ankyrin repeat GO:0055085//GO:0006144//GO:0006508//GO:0006811 transmembrane transport//purine nucleobase metabolic process//proteolysis//ion transport GO:0005515//GO:0005216//GO:0003968//GO:0004197//GO:0017111 protein binding//ion channel activity//RNA-directed RNA polymerase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex -- -- Cluster-8309.47734 BF_2 854.19 5.36 6958 642935550 XP_008198055.1 345 4.5e-29 PREDICTED: toxin S6C6 [Tribolium castaneum] -- -- -- -- -- K04008 CD59 CD59 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K04008 -- -- -- -- PF01051//PF00087 Initiator Replication protein//Snake toxin GO:0006270//GO:0009405//GO:0006260 DNA replication initiation//pathogenesis//DNA replication GO:0003887 DNA-directed DNA polymerase activity GO:0042575//GO:0005727//GO:0005576 DNA polymerase complex//extrachromosomal circular DNA//extracellular region -- -- Cluster-8309.47737 BF_2 26.33 0.74 1778 642915807 XP_008200086.1 1110 2.2e-118 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 817218728 XM_012429755.1 250 8.47762e-126 PREDICTED: Orussus abietinus WD repeat-containing protein 47-like (LOC105702288), partial mRNA -- -- -- -- Q8CGF6 571 2.9e-57 WD repeat-containing protein 47 OS=Mus musculus GN=Wdr47 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47740 BF_2 125.27 1.26 4430 642937338 XP_008198794.1 871 2.9e-90 PREDICTED: innexin inx7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3W6 554 6.8e-55 Innexin inx7 OS=Drosophila melanogaster GN=Inx7 PE=2 SV=1 PF00876//PF05274 Innexin//Occlusion-derived virus envelope protein E25 -- -- -- -- GO:0019031//GO:0005921//GO:0042025 viral envelope//gap junction//host cell nucleus -- -- Cluster-8309.47744 BF_2 3.00 0.45 563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47747 BF_2 23.39 0.33 3258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05550 Pestivirus Npro endopeptidase C53 GO:0016032//GO:0019082 viral process//viral protein processing -- -- -- -- -- -- Cluster-8309.47750 BF_2 30.00 1.22 1317 62089222 BAD93055.1 943 3.8e-99 heat shock 70kDa protein 1A variant [Homo sapiens] 261857773 AB527245.1 511 0 Synthetic construct DNA, clone: pF1KB9773, Homo sapiens HSPA1A gene for heat shock 70kDa protein 1A, without stop codon, in Flexi system K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P0DMV9 935 1.3e-99 Heat shock 70 kDa protein 1B OS=Homo sapiens GN=HSPA1B PE=1 SV=1 PF06723//PF00543//PF01791 MreB/Mbl protein//Nitrogen regulatory protein P-II//DeoC/LacD family aldolase GO:0000902//GO:0006808 cell morphogenesis//regulation of nitrogen utilization GO:0016829//GO:0030234 lyase activity//enzyme regulator activity -- -- -- -- Cluster-8309.47751 BF_2 1305.17 35.81 1812 189235224 XP_967725.2 2213 2.9e-246 PREDICTED: coatomer subunit delta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 1501 4.3e-165 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.47754 BF_2 64.32 0.71 4101 642919579 XP_008191929.1 2776 3.2e-311 PREDICTED: heat shock 70 kDa protein 4 isoform X2 [Tribolium castaneum]>gi|270005857|gb|EFA02305.1| hypothetical protein TcasGA2_TC007971 [Tribolium castaneum] -- -- -- -- -- K09489 HSPA4 heat shock 70kDa protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09489 Q61316 1784 1.5e-197 Heat shock 70 kDa protein 4 OS=Mus musculus GN=Hspa4 PE=1 SV=1 PF06723//PF04355 MreB/Mbl protein//SmpA / OmlA family GO:0000902 cell morphogenesis GO:0005524 ATP binding GO:0019867 outer membrane KOG0103 Molecular chaperones HSP105/HSP110/SSE1, HSP70 superfamily Cluster-8309.47759 BF_2 26.00 0.39 3078 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09003 Bacteriophage lambda integrase, N-terminal domain GO:0015074 DNA integration GO:0003677//GO:0008907 DNA binding//integrase activity -- -- -- -- Cluster-8309.47764 BF_2 10.19 1.50 571 546675793 ERL86913.1 350 9.6e-31 hypothetical protein D910_04316 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47766 BF_2 89.11 0.72 5474 820854616 XP_012344603.1 3462 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X2 [Apis florea] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 1408 7.9e-154 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF08826//PF03592//PF06008//PF09177//PF04111 DMPK coiled coil domain like//Terminase small subunit//Laminin Domain I//Syntaxin 6, N-terminal//Autophagy protein Apg6 GO:0045995//GO:0006323//GO:0030155//GO:0048193//GO:0016310//GO:0006914//GO:0009069//GO:0006468//GO:0030334//GO:0007165 regulation of embryonic development//DNA packaging//regulation of cell adhesion//Golgi vesicle transport//phosphorylation//autophagy//serine family amino acid metabolic process//protein phosphorylation//regulation of cell migration//signal transduction GO:0004674//GO:0005102//GO:0005524 protein serine/threonine kinase activity//receptor binding//ATP binding GO:0016020 membrane KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.47768 BF_2 10.00 0.44 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47770 BF_2 7.18 0.32 1232 642921436 XP_008192865.1 388 8.2e-35 PREDICTED: ral GTPase-activating protein subunit beta isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X10 217 2.3e-16 Ral GTPase-activating protein subunit beta OS=Homo sapiens GN=RALGAPB PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47771 BF_2 314.35 2.13 6461 270006298 EFA02746.1 2906 0.0e+00 hypothetical protein TcasGA2_TC008477 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 1324 5.1e-144 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF00237//PF00876//PF02145 Ribosomal protein L22p/L17e//Innexin//Rap/ran-GAP GO:0006412//GO:0042254//GO:0051056 translation//ribosome biogenesis//regulation of small GTPase mediated signal transduction GO:0005096//GO:0003735 GTPase activator activity//structural constituent of ribosome GO:0005921//GO:0005840 gap junction//ribosome KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.47775 BF_2 658.00 16.52 1953 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47777 BF_2 7.31 0.56 837 189238013 XP_001813375.1 468 2.9e-44 PREDICTED: ATP-binding cassette sub-family B member 7, mitochondrial [Tribolium castaneum]>gi|270008053|gb|EFA04501.1| hypothetical protein TcasGA2_TC014809 [Tribolium castaneum] -- -- -- -- -- K05662 ABCB7 ATP-binding cassette, subfamily B (MDR/TAP), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05662 Q704E8 210 9.9e-16 ATP-binding cassette sub-family B member 7, mitochondrial OS=Rattus norvegicus GN=Abcb7 PE=1 SV=1 -- -- -- -- GO:0017111 nucleoside-triphosphatase activity -- -- KOG0057 Mitochondrial Fe/S cluster exporter, ABC superfamily Cluster-8309.47780 BF_2 144.40 2.22 3014 546682611 ERL92528.1 524 3.4e-50 hypothetical protein D910_09841 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0P3X7 213 1.6e-15 UPF0545 protein C22orf39 homolog OS=Danio rerio PE=3 SV=2 PF03581 Herpesvirus UL33-like protein GO:0019073 viral DNA genome packaging -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.47782 BF_2 303.52 6.13 2360 642921426 XP_008192862.1 1167 7.3e-125 PREDICTED: kelch domain-containing protein 3 [Tribolium castaneum]>gi|270006295|gb|EFA02743.1| hypothetical protein TcasGA2_TC008474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYI2 741 7.5e-77 Kelch domain-containing protein 3 OS=Rattus norvegicus GN=Klhdc3 PE=2 SV=1 PF07646//PF01344//PF03089 Kelch motif//Kelch motif//Recombination activating protein 2 GO:0006310 DNA recombination GO:0003677//GO:0005515 DNA binding//protein binding GO:0005634 nucleus KOG4693 Uncharacterized conserved protein, contains kelch repeat Cluster-8309.47785 BF_2 6.00 6.51 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47788 BF_2 627.14 31.28 1126 91087407 XP_975668.1 598 3.3e-59 PREDICTED: microtubule-associated protein Jupiter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4KBL1 140 1.8e-07 Microtubule-associated protein Jupiter OS=Drosophila mojavensis GN=Jupiter PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47789 BF_2 203.76 2.98 3149 91089227 XP_968078.1 1676 9.3e-184 PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum]>gi|642932923|ref|XP_008197189.1| PREDICTED: sarcolemmal membrane-associated protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14BN4 699 7.4e-72 Sarcolemmal membrane-associated protein OS=Homo sapiens GN=SLMAP PE=1 SV=1 PF00498 FHA domain -- -- GO:0005515 protein binding -- -- KOG3872 FOG: FHA domain Cluster-8309.47791 BF_2 151.17 5.83 1371 91084587 XP_974100.1 1387 1.3e-150 PREDICTED: zinc finger FYVE domain-containing protein 9 [Tribolium castaneum]>gi|270008651|gb|EFA05099.1| hypothetical protein TcasGA2_TC015198 [Tribolium castaneum] -- -- -- -- -- K04679 MADHIP, SARA MAD, mothers against decapentaplegic interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K04679 O95405 824 1.0e-86 Zinc finger FYVE domain-containing protein 9 OS=Homo sapiens GN=ZFYVE9 PE=1 SV=2 -- -- -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47793 BF_2 17.38 0.60 1493 91084337 XP_972793.1 262 4.0e-20 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 50 1.07182e-14 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47794 BF_2 42.62 1.20 1779 646709836 KDR15525.1 1362 1.3e-147 Vacuolar protein sorting-associated protein 26B-like [Zootermopsis nevadensis] 884922933 XM_003472567.3 171 6.98846e-82 PREDICTED: Cavia porcellus VPS26 retromer complex component B (Vps26b), mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q9W552 1278 3.0e-139 Vacuolar protein sorting-associated protein 26 OS=Drosophila melanogaster GN=Vps26 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.47795 BF_2 583.43 19.16 1561 91084541 XP_972999.1 1668 3.9e-183 PREDICTED: vacuolar protein sorting-associated protein 26B-like [Tribolium castaneum]>gi|270008666|gb|EFA05114.1| hypothetical protein TcasGA2_TC015215 [Tribolium castaneum] 545849340 XM_003482653.2 172 1.70017e-82 PREDICTED: Sus scrofa vacuolar protein sorting-associated protein 26B-like (LOC100738900), mRNA K18466 VPS26 vacuolar protein sorting-associated protein 26 http://www.genome.jp/dbget-bin/www_bget?ko:K18466 Q9W552 1261 2.5e-137 Vacuolar protein sorting-associated protein 26 OS=Drosophila melanogaster GN=Vps26 PE=2 SV=1 -- -- GO:0007034 vacuolar transport -- -- GO:0030904 retromer complex KOG3063 Membrane coat complex Retromer, subunit VPS26 Cluster-8309.47798 BF_2 387.42 2.32 7266 642918330 XP_008199110.1 5143 0.0e+00 PREDICTED: tyrosine-protein kinase Abl [Tribolium castaneum] 815766251 XM_012363285.1 447 0 PREDICTED: Linepithema humile tyrosine-protein kinase Abl (LOC105670007), mRNA K06619 ABL1 abelson tyrosine-protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06619 P00522 2688 4.0e-302 Tyrosine-protein kinase Abl OS=Drosophila melanogaster GN=Abl PE=1 SV=3 PF14604//PF00018//PF08919//PF00069//PF07714 Variant SH3 domain//SH3 domain//F-actin binding//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0004715//GO:0005524 protein binding//protein kinase activity//non-membrane spanning protein tyrosine kinase activity//ATP binding -- -- KOG4278 Protein tyrosine kinase Cluster-8309.478 BF_2 7.00 1.22 527 554548683 XP_005868880.1 766 5.1e-79 PREDICTED: LOW QUALITY PROTEIN: ribosomal protein S16 [Myotis brandtii] 71482588 NM_001020.4 527 0 Homo sapiens ribosomal protein S16 (RPS16), mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 Q3T0X6 744 7.5e-78 40S ribosomal protein S16 OS=Bos taurus GN=RPS16 PE=2 SV=3 PF00380 Ribosomal protein S9/S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.47801 BF_2 190.00 1.88 4525 642933801 XP_008197340.1 1564 1.3e-170 PREDICTED: sphingosine-1-phosphate phosphatase 1-like [Tribolium castaneum]>gi|270013628|gb|EFA10076.1| hypothetical protein TcasGA2_TC012252 [Tribolium castaneum] 242013612 XM_002427452.1 98 6.84423e-41 Pediculus humanus corporis sphingosine-1-phosphate phosphatase, putative, mRNA K04716 SGPP1 sphingosine-1-phosphate phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04716 Q9BX95 650 5.1e-66 Sphingosine-1-phosphate phosphatase 1 OS=Homo sapiens GN=SGPP1 PE=1 SV=2 -- -- GO:0008152 metabolic process GO:0003824 catalytic activity GO:0016020 membrane KOG2822 Sphingoid base-phosphate phosphatase Cluster-8309.47802 BF_2 463.00 18.21 1351 642923823 XP_008193894.1 754 3.3e-77 PREDICTED: uncharacterized protein LOC103313156 [Tribolium castaneum]>gi|270007762|gb|EFA04210.1| hypothetical protein TcasGA2_TC014459 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062//PF13903//PF09446 Clc-like//PMP-22/EMP/MP20/Claudin tight junction//VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47803 BF_2 797.98 4.13 8374 642938555 XP_008199840.1 3495 0.0e+00 PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum]>gi|642938557|ref|XP_008199841.1| PREDICTED: catenin delta-2 isoform X1 [Tribolium castaneum] 642938558 XR_511746.1 676 0 PREDICTED: Tribolium castaneum catenin delta-2 (LOC100141625), transcript variant X3, misc_RNA K02366 EXT1 glucuronyl/N-acetylglucosaminyl transferase EXT1 http://www.genome.jp/dbget-bin/www_bget?ko:K02366 Q9V730 2376 6.9e-266 Exostosin-1 OS=Drosophila melanogaster GN=ttv PE=1 SV=1 PF02985//PF00514//PF01602//PF01312//PF09258 HEAT repeat//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//FlhB HrpN YscU SpaS Family//Glycosyl transferase family 64 domain GO:0015012//GO:0009306//GO:0006024//GO:0016192//GO:0006886 heparan sulfate proteoglycan biosynthetic process//protein secretion//glycosaminoglycan biosynthetic process//vesicle-mediated transport//intracellular protein transport GO:0005515 protein binding GO:0016020//GO:0030117//GO:0016021 membrane//membrane coat//integral component of membrane KOG1048 Neural adherens junction protein Plakophilin and related Armadillo repeat proteins Cluster-8309.47805 BF_2 236.00 8.11 1505 332375150 AEE62716.1 1178 2.5e-126 unknown [Dendroctonus ponderosae] 195568600 XM_002102266.1 65 4.9571e-23 Drosophila simulans GD19834 (Dsim\GD19834), mRNA K04405 ECSIT evolutionarily conserved signaling intermediate in Toll pathway http://www.genome.jp/dbget-bin/www_bget?ko:K04405 Q9U6M0 968 2.3e-103 Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial OS=Drosophila melanogaster GN=ECSIT PE=1 SV=2 PF01777 Ribosomal L27e protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3941 Intermediate in Toll signal transduction pathway (ECSIT) Cluster-8309.47806 BF_2 662.87 4.08 7080 91077136 XP_971386.1 4613 0.0e+00 PREDICTED: methyl-CpG-binding domain protein 5 isoform X2 [Tribolium castaneum]>gi|270001717|gb|EEZ98164.1| hypothetical protein TcasGA2_TC000591 [Tribolium castaneum] 462383301 APGK01021303.1 73 8.47656e-27 Dendroctonus ponderosae Seq01021313, whole genome shotgun sequence -- -- -- -- Q9P267 256 3.9e-20 Methyl-CpG-binding domain protein 5 OS=Homo sapiens GN=MBD5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47809 BF_2 642.78 3.95 7092 91077136 XP_971386.1 4613 0.0e+00 PREDICTED: methyl-CpG-binding domain protein 5 isoform X2 [Tribolium castaneum]>gi|270001717|gb|EEZ98164.1| hypothetical protein TcasGA2_TC000591 [Tribolium castaneum] 462383301 APGK01021303.1 73 8.491e-27 Dendroctonus ponderosae Seq01021313, whole genome shotgun sequence -- -- -- -- Q9P267 256 3.9e-20 Methyl-CpG-binding domain protein 5 OS=Homo sapiens GN=MBD5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47811 BF_2 311.00 6.44 2307 91086585 XP_973508.1 2209 1.1e-245 PREDICTED: trafficking protein particle complex subunit 12 [Tribolium castaneum]>gi|270010359|gb|EFA06807.1| hypothetical protein TcasGA2_TC009746 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K2L8 890 3.9e-94 Trafficking protein particle complex subunit 12 OS=Mus musculus GN=Trappc12 PE=1 SV=2 PF13374//PF13181//PF07721//PF00515//PF13414//PF13174//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG2796 Uncharacterized conserved protein Cluster-8309.47815 BF_2 195.31 13.46 894 332375216 AEE62749.1 600 1.5e-59 unknown [Dendroctonus ponderosae]>gi|478260771|gb|ENN80443.1| hypothetical protein YQE_03135, partial [Dendroctonus ponderosae]>gi|546679580|gb|ERL90028.1| hypothetical protein D910_07386 [Dendroctonus ponderosae] -- -- -- -- -- K17197 NKIRAS NF-kappa-B inhibitor-interacting Ras-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17197 Q9V4L4 336 2.6e-30 NF-kappa-B inhibitor-interacting Ras-like protein OS=Drosophila melanogaster GN=kappaB-Ras PE=1 SV=1 PF00004//PF00025//PF08477//PF01926//PF00493//PF00071//PF00931//PF01637 ATPase family associated with various cellular activities (AAA)//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//MCM2/3/5 family//Ras family//NB-ARC domain//Archaeal ATPase GO:0006260//GO:0007264 DNA replication//small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003677//GO:0043531 ATP binding//GTP binding//DNA binding//ADP binding -- -- -- -- Cluster-8309.47823 BF_2 17.00 0.34 2403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00876 Innexin -- -- -- -- GO:0005921 gap junction -- -- Cluster-8309.47824 BF_2 13.89 0.56 1328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47826 BF_2 77.00 1.76 2116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01985 CRS1 / YhbY (CRM) domain -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.47828 BF_2 22.00 19.39 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47831 BF_2 10.98 0.53 1148 642923056 XP_008200513.1 322 3.4e-27 PREDICTED: fibronectin type-III domain-containing protein 3A isoform X4 [Tribolium castaneum]>gi|270006595|gb|EFA03043.1| hypothetical protein TcasGA2_TC010469 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47832 BF_2 84.08 0.32 11123 642911559 XP_970343.3 5214 0.0e+00 PREDICTED: chromodomain-helicase-DNA-binding protein 1 [Tribolium castaneum] 755977937 XM_011310121.1 360 0 PREDICTED: Fopius arisanus chromodomain-helicase-DNA-binding protein 1 (LOC105269677), transcript variant X5, mRNA K11367 CHD1 chromodomain-helicase-DNA-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11367 A9X4T1 4055 0.0e+00 Chromodomain-helicase-DNA-binding protein 1 OS=Bombyx mori GN=CHD1 PE=1 SV=1 PF03808//PF08074//PF00640//PF04689//PF00176//PF04851 Glycosyl transferase WecB/TagA/CpsF family//CHDCT2 (NUC038) domain//Phosphotyrosine interaction domain (PTB/PID)//DNA binding protein S1FA//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0008270//GO:0016818//GO:0016787//GO:0003677//GO:0005524//GO:0005515 zinc ion binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//hydrolase activity//DNA binding//ATP binding//protein binding GO:0005634 nucleus KOG0384 Chromodomain-helicase DNA-binding protein Cluster-8309.47837 BF_2 136.59 12.51 744 478254757 ENN74994.1 180 6.5e-11 hypothetical protein YQE_08451, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7PSY2 164 1.9e-10 UPF0729 protein AGAP000931 OS=Anopheles gambiae GN=AGAP000931 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47838 BF_2 73.32 1.31 2636 546683891 ERL93639.1 995 7.2e-105 hypothetical protein D910_10927 [Dendroctonus ponderosae] -- -- -- -- -- K06233 LRP2 low density lipoprotein-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06233 Q9NZR2 179 1.2e-11 Low-density lipoprotein receptor-related protein 1B OS=Homo sapiens GN=LRP1B PE=1 SV=2 PF00057 Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.47840 BF_2 366.68 6.90 2511 859132814 AKO63320.1 1120 2.2e-119 mevalonate kinase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9R008 406 5.6e-38 Mevalonate kinase OS=Mus musculus GN=Mvk PE=2 SV=1 PF00288//PF04055 GHMP kinases N terminal domain//Radical SAM superfamily -- -- GO:0051536//GO:0005524//GO:0003824 iron-sulfur cluster binding//ATP binding//catalytic activity -- -- KOG1511 Mevalonate kinase MVK/ERG12 Cluster-8309.47842 BF_2 6.56 1.65 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47843 BF_2 199.57 9.16 1199 91094895 XP_973250.1 912 1.4e-95 PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923028|ref|XP_008200501.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum]>gi|642923030|ref|XP_008200502.1| PREDICTED: putative uncharacterized protein C3orf83 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- H3BPM6 338 2.1e-30 MKRN2 opposite strand protein OS=Homo sapiens GN=MKRN2OS PE=4 SV=1 PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.47844 BF_2 44.98 0.51 4002 91091542 XP_970835.1 1645 4.6e-180 PREDICTED: retinal dehydrogenase 1 [Tribolium castaneum]>gi|270000922|gb|EEZ97369.1| hypothetical protein TcasGA2_TC011192 [Tribolium castaneum] -- -- -- -- -- K07249 E1.2.1.36 retinal dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07249 Q62148 1318 1.6e-143 Retinal dehydrogenase 2 OS=Mus musculus GN=Aldh1a2 PE=2 SV=2 PF00705//PF00171 Proliferating cell nuclear antigen, N-terminal domain//Aldehyde dehydrogenase family GO:0008152//GO:0006275//GO:0055114 metabolic process//regulation of DNA replication//oxidation-reduction process GO:0003677//GO:0016491//GO:0016620 DNA binding//oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.47845 BF_2 492.21 5.91 3771 91091542 XP_970835.1 1726 1.8e-189 PREDICTED: retinal dehydrogenase 1 [Tribolium castaneum]>gi|270000922|gb|EEZ97369.1| hypothetical protein TcasGA2_TC011192 [Tribolium castaneum] -- -- -- -- -- K07249 E1.2.1.36 retinal dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07249 Q66HF8 1365 5.3e-149 Aldehyde dehydrogenase X, mitochondrial OS=Rattus norvegicus GN=Aldh1b1 PE=1 SV=1 PF00171//PF00705 Aldehyde dehydrogenase family//Proliferating cell nuclear antigen, N-terminal domain GO:0008152//GO:0006275//GO:0055114 metabolic process//regulation of DNA replication//oxidation-reduction process GO:0003677//GO:0016491 DNA binding//oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.47846 BF_2 36.01 0.51 3216 91084489 XP_971806.1 629 2.4e-62 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.47848 BF_2 64.80 1.47 2132 642915964 XP_008190829.1 1006 3.1e-106 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 1.3e-27 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47850 BF_2 18.00 0.68 1389 662191266 XP_008468441.1 682 7.5e-69 PREDICTED: transposable element P transposase [Diaphorina citri] -- -- -- -- -- -- -- -- -- Q7M3K2 364 2.3e-33 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47851 BF_2 1753.11 24.93 3229 642939454 XP_008200409.1 1602 3.6e-175 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum]>gi|270016515|gb|EFA12961.1| hypothetical protein TcasGA2_TC001412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 696 1.7e-71 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.47852 BF_2 1.00 1.78 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47853 BF_2 198.84 1.07 8069 642918330 XP_008199110.1 2885 0.0e+00 PREDICTED: tyrosine-protein kinase Abl [Tribolium castaneum] 815766251 XM_012363285.1 453 0 PREDICTED: Linepithema humile tyrosine-protein kinase Abl (LOC105670007), mRNA K06619 ABL1 abelson tyrosine-protein kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06619 P00522 2331 1.1e-260 Tyrosine-protein kinase Abl OS=Drosophila melanogaster GN=Abl PE=1 SV=3 PF14604//PF00018//PF00069//PF08919//PF07714 Variant SH3 domain//SH3 domain//Protein kinase domain//F-actin binding//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0004715 protein binding//protein kinase activity//ATP binding//non-membrane spanning protein tyrosine kinase activity -- -- KOG4278 Protein tyrosine kinase Cluster-8309.47854 BF_2 579.00 4.78 5351 478257233 ENN77396.1 1644 8.1e-180 hypothetical protein YQE_06221, partial [Dendroctonus ponderosae] 751455975 XM_011184231.1 54 2.33423e-16 PREDICTED: Bactrocera cucurbitae heparan-sulfate 6-O-sulfotransferase 2 (LOC105212331), transcript variant X2, mRNA K02514 HS6ST1 heparan sulfate 6-O-sulfotransferase HS6ST1 http://www.genome.jp/dbget-bin/www_bget?ko:K02514 Q76KB2 785 1.3e-81 Heparan-sulfate 6-O-sulfotransferase 1 OS=Gallus gallus GN=HS6ST1 PE=1 SV=4 PF00622//PF06990//PF03567 SPRY domain//Galactose-3-O-sulfotransferase//Sulfotransferase family GO:0009058//GO:0006687 biosynthetic process//glycosphingolipid metabolic process GO:0008146//GO:0005515//GO:0001733 sulfotransferase activity//protein binding//galactosylceramide sulfotransferase activity GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG4030 Uncharacterized conserved protein, contains SPRY domain Cluster-8309.47856 BF_2 12.00 0.57 1171 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47857 BF_2 10.00 11.70 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47859 BF_2 39.37 0.91 2092 478254028 ENN74320.1 1274 2.5e-137 hypothetical protein YQE_09291, partial [Dendroctonus ponderosae] -- -- -- -- -- K09048 CREB3 cyclic AMP-responsive element-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09048 Q9D2A5 304 3.1e-26 Cyclic AMP-responsive element-binding protein 3-like protein 4 OS=Mus musculus GN=Creb3l4 PE=1 SV=1 PF03131//PF04281//PF11365//PF07716//PF00170 bZIP Maf transcription factor//Mitochondrial import receptor subunit Tom22//Protein of unknown function (DUF3166)//Basic region leucine zipper//bZIP transcription factor GO:0006355//GO:0010506//GO:0006886 regulation of transcription, DNA-templated//regulation of autophagy//intracellular protein transport GO:0043565//GO:0003700//GO:0003677 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005741//GO:0005615//GO:0005634//GO:0005667 mitochondrial outer membrane//extracellular space//nucleus//transcription factor complex KOG0709 CREB/ATF family transcription factor Cluster-8309.47864 BF_2 48.03 1.43 1691 91088847 XP_970872.1 1342 2.7e-145 PREDICTED: adenosine kinase [Tribolium castaneum]>gi|270011602|gb|EFA08050.1| hypothetical protein TcasGA2_TC005644 [Tribolium castaneum] -- -- -- -- -- K00856 E2.7.1.20, ADK adenosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00856 P55264 930 6.5e-99 Adenosine kinase OS=Mus musculus GN=Adk PE=1 SV=2 PF00113 Enolase, C-terminal TIM barrel domain GO:0006094//GO:0009094//GO:0006166//GO:0006571//GO:0000162//GO:0006096//GO:0006144//GO:0006167 gluconeogenesis//L-phenylalanine biosynthetic process//purine ribonucleoside salvage//tyrosine biosynthetic process//tryptophan biosynthetic process//glycolytic process//purine nucleobase metabolic process//AMP biosynthetic process GO:0016773//GO:0000287//GO:0004001//GO:0004634 phosphotransferase activity, alcohol group as acceptor//magnesium ion binding//adenosine kinase activity//phosphopyruvate hydratase activity GO:0000015 phosphopyruvate hydratase complex KOG2854 Possible pfkB family carbohydrate kinase Cluster-8309.47866 BF_2 3.51 0.62 524 642912259 XP_008200626.1 167 1.5e-09 PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|642912261|ref|XP_008200627.1| PREDICTED: uncharacterized protein LOC103314979 [Tribolium castaneum]>gi|270002461|gb|EEZ98908.1| hypothetical protein TcasGA2_TC004527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01805 Surp module GO:0006396 RNA processing GO:0003723 RNA binding -- -- -- -- Cluster-8309.47868 BF_2 84.00 6.44 833 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47869 BF_2 859.43 9.33 4139 642913457 XP_008201020.1 4038 0.0e+00 PREDICTED: ankyrin repeat domain-containing protein 17 [Tribolium castaneum] 768423943 XM_011554601.1 357 0 PREDICTED: Plutella xylostella ankyrin repeat domain-containing protein 17-like (LOC105384370), partial mRNA K16726 ANKRD17, MASK ankyrin repeat domain-containing protein 17 http://www.genome.jp/dbget-bin/www_bget?ko:K16726 Q99NH0 2220 4.2e-248 Ankyrin repeat domain-containing protein 17 OS=Mus musculus GN=Ankrd17 PE=1 SV=2 PF00023//PF00784//PF13606 Ankyrin repeat//MyTH4 domain//Ankyrin repeat -- -- GO:0005515 protein binding GO:0005856 cytoskeleton -- -- Cluster-8309.47872 BF_2 298.00 7.18 2024 642910650 XP_968863.2 2068 2.1e-229 PREDICTED: protein hook [Tribolium castaneum] -- -- -- -- -- K16536 HOOK3 protein HOOK3 http://www.genome.jp/dbget-bin/www_bget?ko:K16536 Q17AF4 1026 5.8e-110 Protein hook OS=Aedes aegypti GN=hk PE=3 SV=1 PF01763//PF01873 Herpesvirus UL6 like//Domain found in IF2B/IF5 GO:0006413//GO:0006323//GO:0006446 translational initiation//DNA packaging//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.47874 BF_2 43.63 4.22 720 642925421 XP_008194544.1 245 1.8e-18 PREDICTED: caldesmon-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47876 BF_2 1.00 1.78 290 749793177 XP_011149868.1 178 4.3e-11 PREDICTED: MLX-interacting protein isoform X2 [Harpegnathos saltator] -- -- -- -- -- K09113 MLX MAX-like protein X http://www.genome.jp/dbget-bin/www_bget?ko:K09113 -- -- -- -- PF04977//PF07716//PF00170//PF00010 Septum formation initiator//Basic region leucine zipper//bZIP transcription factor//Helix-loop-helix DNA-binding domain GO:0007049//GO:0006355 cell cycle//regulation of transcription, DNA-templated GO:0003700//GO:0046983//GO:0043565 transcription factor activity, sequence-specific DNA binding//protein dimerization activity//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.47878 BF_2 21.31 0.43 2350 91081429 XP_973458.1 1554 9.7e-170 PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|642920877|ref|XP_008192597.1| PREDICTED: ATP-binding cassette sub-family G member 4 [Tribolium castaneum]>gi|270006127|gb|EFA02575.1| hypothetical protein TcasGA2_TC008293 [Tribolium castaneum] 749790449 XM_011150162.1 130 5.74328e-59 PREDICTED: Harpegnathos saltator ATP-binding cassette sub-family G member 4 (LOC105188614), mRNA K05680 ABCG4 ATP-binding cassette, subfamily G (WHITE), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05680 Q9H172 946 1.3e-100 ATP-binding cassette sub-family G member 4 OS=Homo sapiens GN=ABCG4 PE=1 SV=2 PF01926//PF13304//PF03193//PF00005 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function, DUF258//ABC transporter GO:0006200 obsolete ATP catabolic process GO:0003924//GO:0016887//GO:0005525//GO:0005524 GTPase activity//ATPase activity//GTP binding//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.47879 BF_2 242.83 4.52 2535 642924099 XP_008194004.1 1356 9.5e-147 PREDICTED: division abnormally delayed protein [Tribolium castaneum] -- -- -- -- -- K02306 DALLY dally http://www.genome.jp/dbget-bin/www_bget?ko:K02306 Q24114 699 6.0e-72 Division abnormally delayed protein OS=Drosophila melanogaster GN=dally PE=1 SV=1 PF01392//PF01153//PF03176//PF07657 Fz domain//Glypican//MMPL family//N terminus of Notch ligand GO:0007219//GO:0007275 Notch signaling pathway//multicellular organismal development GO:0005515//GO:0043395 protein binding//heparan sulfate proteoglycan binding GO:0016021//GO:0016020//GO:0005578 integral component of membrane//membrane//proteinaceous extracellular matrix -- -- Cluster-8309.47880 BF_2 5.00 0.53 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47882 BF_2 455.20 30.38 914 91087999 XP_973740.1 783 9.5e-81 PREDICTED: UPF0454 protein C12orf49 homolog [Tribolium castaneum]>gi|270011897|gb|EFA08345.1| hypothetical protein TcasGA2_TC005988 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNT2 462 6.5e-45 UPF0454 protein C12orf49 homolog OS=Xenopus laevis PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3136 Uncharacterized conserved protein Cluster-8309.47886 BF_2 579.54 3.62 6989 642934824 XP_008197825.1 4092 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 5.1e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 PF00610 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556 intracellular signal transduction -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47887 BF_2 155.62 1.92 3669 642934824 XP_008197825.1 4487 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 2.7e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47889 BF_2 114.07 1.44 3597 642934830 XP_008197828.1 4401 0.0e+00 PREDICTED: DEP domain-containing protein 5 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75140 1859 2.6e-206 DEP domain-containing protein 5 OS=Homo sapiens GN=DEPDC5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3572 Uncharacterized conserved protein, contains DEP domain Cluster-8309.47890 BF_2 1.00 1.24 307 808127224 XP_012166572.1 221 4.7e-16 PREDICTED: LOW QUALITY PROTEIN: fatty acid synthase [Bombus terrestris] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 148 5.6e-09 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47891 BF_2 3.00 0.56 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47893 BF_2 55.70 1.19 2252 546672885 ERL84608.1 1433 1.0e-155 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 1101 1.3e-118 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00108//PF08545 Thiolase, N-terminal domain//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0008152//GO:0006633//GO:0042967 metabolic process//fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0016747//GO:0004315 transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0005835 fatty acid synthase complex KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.47894 BF_2 248.35 2.17 5073 642934565 XP_008197717.1 1516 5.3e-165 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47895 BF_2 6.00 6.06 318 546686701 ERL95808.1 171 3.0e-10 hypothetical protein D910_00344, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47896 BF_2 32.04 0.37 3942 478256593 ENN76775.1 2995 0.0e+00 hypothetical protein YQE_06616, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9Z1L5 1088 7.3e-117 Voltage-dependent calcium channel subunit alpha-2/delta-3 OS=Mus musculus GN=Cacna2d3 PE=1 SV=1 PF08030//PF05483 Ferric reductase NAD binding domain//Synaptonemal complex protein 1 (SCP-1) GO:0007130//GO:0055114 synaptonemal complex assembly//oxidation-reduction process GO:0016491 oxidoreductase activity GO:0000795 synaptonemal complex KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.47899 BF_2 440.25 5.89 3413 642933817 XP_008197388.1 565 6.8e-55 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.479 BF_2 6.28 2.04 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.47900 BF_2 363.44 21.12 1007 642926177 XP_008194817.1 792 9.5e-82 PREDICTED: protein LSM12 homolog A-like [Tribolium castaneum]>gi|270008537|gb|EFA04985.1| hypothetical protein TcasGA2_TC015064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZML5 382 1.4e-35 Protein LSM12 homolog OS=Gallus gallus GN=LSM12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4401 Uncharacterized conserved protein Cluster-8309.47901 BF_2 62.77 1.61 1923 642917480 XP_008191219.1 777 1.0e-79 PREDICTED: probable RNA-binding protein 18 [Tribolium castaneum]>gi|270004407|gb|EFA00855.1| hypothetical protein TcasGA2_TC003758 [Tribolium castaneum] 642917479 XM_008192997.1 137 6.01634e-63 PREDICTED: Tribolium castaneum probable RNA-binding protein 18 (LOC103312423), mRNA -- -- -- -- Q6PBM8 292 7.1e-25 Probable RNA-binding protein 18 OS=Danio rerio GN=rbm18 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.47902 BF_2 493.14 50.70 694 642927976 XP_008195469.1 559 6.8e-55 PREDICTED: leptin receptor gene-related protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3Y064 399 1.0e-37 Leptin receptor gene-related protein OS=Takifugu rubripes GN=leprot PE=2 SV=1 PF07440//PF07155 Caerin 1 protein//ECF-type riboflavin transporter, S component -- -- -- -- GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.47904 BF_2 107.31 1.32 3686 270012487 EFA08935.1 2481 4.9e-277 hypothetical protein TcasGA2_TC006642 [Tribolium castaneum] 645037466 XM_008219044.1 211 8.49403e-104 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1544 9.0e-170 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF09604//PF02214//PF00520 F subunit of K+-transporting ATPase (Potass_KdpF)//BTB/POZ domain//Ion transport protein GO:0043462//GO:0055085//GO:0006813//GO:0051260//GO:0006811 regulation of ATPase activity//transmembrane transport//potassium ion transport//protein homooligomerization//ion transport GO:0008556//GO:0005216 potassium-transporting ATPase activity//ion channel activity GO:0005886//GO:0016020 plasma membrane//membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.47908 BF_2 80.00 0.81 4425 642934496 XP_008197689.1 1102 4.7e-117 PREDICTED: nascent polypeptide-associated complex subunit alpha, muscle-specific form-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PR54 167 5.1e-10 Telomere-associated protein RIF1 OS=Mus musculus GN=Rif1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47909 BF_2 225.80 0.74 13028 270007354 EFA03802.1 5836 0.0e+00 hypothetical protein TcasGA2_TC013915 [Tribolium castaneum] 642917043 XM_008192874.1 352 0 PREDICTED: Tribolium castaneum diacylglycerol kinase eta-like (LOC103312380), mRNA K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 B4K6T8 2049 8.8e-228 Diacylglycerol kinase eta OS=Drosophila mojavensis GN=GI24133 PE=3 SV=1 PF00536//PF00609//PF00130//PF02017//PF07647//PF00749//PF07649//PF02198//PF16866//PF00781 SAM domain (Sterile alpha motif)//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//CIDE-N domain//SAM domain (Sterile alpha motif)//tRNA synthetases class I (E and Q), catalytic domain//C1-like domain//Sterile alpha motif (SAM)/Pointed domain//PHD-finger//Diacylglycerol kinase catalytic domain GO:0043039//GO:0007205//GO:0009395//GO:0046486//GO:0006915//GO:0035556//GO:0055114 tRNA aminoacylation//protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process//apoptotic process//intracellular signal transduction//oxidation-reduction process GO:0005515//GO:0004143//GO:0047134//GO:0016876//GO:0016301//GO:0043565//GO:0005524 protein binding//diacylglycerol kinase activity//protein-disulfide reductase activity//ligase activity, forming aminoacyl-tRNA and related compounds//kinase activity//sequence-specific DNA binding//ATP binding GO:0005634//GO:0005622 nucleus//intracellular KOG1170 Diacylglycerol kinase Cluster-8309.47910 BF_2 402.00 7.99 2391 642936706 XP_008198547.1 835 2.3e-86 PREDICTED: uncharacterized protein C17orf85 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q803E1 227 3.0e-17 Uncharacterized protein C17orf85 homolog OS=Danio rerio GN=zgc:55870 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47912 BF_2 39.51 2.81 875 91084843 XP_966905.1 424 3.9e-39 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 162 3.8e-10 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.47914 BF_2 31.30 0.37 3784 546676181 ERL87248.1 2332 9.6e-260 hypothetical protein D910_04646 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9R9I9 664 1.0e-67 Mycosubtilin synthase subunit C OS=Bacillus subtilis GN=mycC PE=3 SV=1 PF02733//PF00501 Dak1 domain//AMP-binding enzyme GO:0006071//GO:0046486//GO:0008152 glycerol metabolic process//glycerolipid metabolic process//metabolic process GO:0004371//GO:0003824 glycerone kinase activity//catalytic activity -- -- KOG1178 Non-ribosomal peptide synthetase/alpha-aminoadipate reductase and related enzymes Cluster-8309.47915 BF_2 124.00 24.94 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47919 BF_2 386.98 4.73 3710 478252950 ENN73334.1 1210 1.2e-129 hypothetical protein YQE_10095, partial [Dendroctonus ponderosae]>gi|546679632|gb|ERL90063.1| hypothetical protein D910_07419 [Dendroctonus ponderosae] -- -- -- -- -- K00637 E2.3.1.26, SOAT sterol O-acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00637 Q60457 838 6.7e-88 Sterol O-acyltransferase 1 OS=Cricetulus griseus GN=SOAT1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0380 Sterol O-acyltransferase/Diacylglycerol O-acyltransferase Cluster-8309.47920 BF_2 783.42 11.86 3051 91093909 XP_970018.1 939 2.6e-98 PREDICTED: cation transport regulator-like protein 1 [Tribolium castaneum]>gi|270014507|gb|EFA10955.1| hypothetical protein TcasGA2_TC004115 [Tribolium castaneum] -- -- -- -- -- K07232 chaC cation transport protein ChaC http://www.genome.jp/dbget-bin/www_bget?ko:K07232 Q9BUX1 467 5.7e-45 Glutathione-specific gamma-glutamylcyclotransferase 1 OS=Homo sapiens GN=CHAC1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47922 BF_2 34.63 0.87 1960 270008949 EFA05397.1 1196 2.6e-128 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 626 1.3e-63 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47924 BF_2 293.11 5.78 2408 189240752 XP_968856.2 777 1.2e-79 PREDICTED: uncharacterized protein LOC657295 isoform X2 [Tribolium castaneum]>gi|642934166|ref|XP_008199634.1| PREDICTED: uncharacterized protein LOC657295 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14135 151 2.0e-08 Transcription cofactor vestigial-like protein 4 OS=Homo sapiens GN=VGLL4 PE=1 SV=4 PF15245//PF07545 Transcription cofactor vestigial-like protein 4//Vestigial/Tondu family GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.47925 BF_2 1.00 4.96 253 805760798 XP_012153830.1 215 1.9e-15 PREDICTED: endophilin-A isoform X3 [Megachile rotundata] 645025278 XR_512247.1 38 7.58268e-09 PREDICTED: Nasonia vitripennis uncharacterized LOC100118568 (LOC100118568), ncRNA K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I1A6 157 4.2e-10 Endophilin-A OS=Drosophila willistoni GN=endoA PE=3 SV=1 PF00018 SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.47930 BF_2 99.09 0.52 8245 546675647 ERL86797.1 3344 0.0e+00 hypothetical protein D910_04202 [Dendroctonus ponderosae] 170039960 XM_001847732.1 106 4.46787e-45 Culex quinquefasciatus phosphatidylinositol 3-kinase 1, mRNA K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 O35904 2100 6.8e-234 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform OS=Mus musculus GN=Pik3cd PE=1 SV=2 PF10415//PF04666//PF09446//PF00454//PF02888//PF00951 Fumarase C C-terminus//N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region//VMA21-like domain//Phosphatidylinositol 3- and 4-kinase//Calmodulin binding domain//Arterivirus GL envelope glycoprotein GO:0006813//GO:0070072//GO:0005975//GO:0006099 potassium ion transport//vacuolar proton-transporting V-type ATPase complex assembly//carbohydrate metabolic process//tricarboxylic acid cycle GO:0015269//GO:0016758//GO:0005516//GO:0016829//GO:0016773 calcium-activated potassium channel activity//transferase activity, transferring hexosyl groups//calmodulin binding//lyase activity//phosphotransferase activity, alcohol group as acceptor GO:0019031//GO:0016021//GO:0016020 viral envelope//integral component of membrane//membrane KOG0904 Phosphatidylinositol 3-kinase catalytic subunit (p110) Cluster-8309.47933 BF_2 67.46 0.60 4965 642911714 XP_008200711.1 876 8.5e-91 PREDICTED: LOW QUALITY PROTEIN: dihydropteridine reductase [Tribolium castaneum] -- -- -- -- -- K00357 QDPR dihydropteridine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00357 P11348 704 3.1e-72 Dihydropteridine reductase OS=Rattus norvegicus GN=Qdpr PE=1 SV=1 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0016491//GO:0003824//GO:0050662 oxidoreductase activity//catalytic activity//coenzyme binding -- -- KOG4022 Dihydropteridine reductase DHPR/QDPR Cluster-8309.47934 BF_2 67.67 1.68 1974 478257290 ENN77453.1 1543 1.5e-168 hypothetical protein YQE_06277, partial [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 942 3.1e-100 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.47936 BF_2 2.00 0.50 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47940 BF_2 125.20 0.77 7117 91081013 XP_975219.1 1786 3.7e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 4.3e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF00096//PF01956//PF13465//PF13912 Zinc finger, C2H2 type//Integral membrane protein DUF106//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding GO:0016020 membrane -- -- Cluster-8309.47941 BF_2 51.34 0.73 3247 91081013 XP_975219.1 1786 1.7e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 2.0e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.47943 BF_2 38.29 0.70 2570 642923250 XP_008193676.1 336 1.8e-28 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] -- -- -- -- -- K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q9VUX2 268 5.8e-22 E3 ubiquitin-protein ligase mind-bomb OS=Drosophila melanogaster GN=mib1 PE=1 SV=3 PF14634//PF00097//PF00569//PF07663//PF06701//PF15898//PF13639 zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc finger, ZZ type//Sorbitol phosphotransferase enzyme II C-terminus//Mib_herc2//cGMP-dependent protein kinase interacting domain//Ring finger domain GO:0009401//GO:0008643//GO:0016567 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport//protein ubiquitination GO:0008982//GO:0019901//GO:0043169//GO:0008270//GO:0046872//GO:0005515//GO:0004842 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase binding//cation binding//zinc ion binding//metal ion binding//protein binding//ubiquitin-protein transferase activity GO:0009357//GO:0016021 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG4582 Uncharacterized conserved protein, contains ZZ-type Zn-finger Cluster-8309.47944 BF_2 535.63 12.57 2070 642911723 XP_008200714.1 359 3.2e-31 PREDICTED: scaffold attachment factor B2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80YR5 202 2.1e-14 Scaffold attachment factor B2 OS=Mus musculus GN=Safb2 PE=2 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.47945 BF_2 119.64 0.58 8947 642910379 XP_008200298.1 7631 0.0e+00 PREDICTED: uncharacterized protein LOC660207 isoform X4 [Tribolium castaneum] 194747504 XM_001956156.1 230 5.68225e-114 Drosophila ananassae GF24721 (Dana\GF24721), mRNA -- -- -- -- Q9CPW0 626 6.2e-63 Contactin-associated protein-like 2 OS=Mus musculus GN=Cntnap2 PE=1 SV=2 PF00014//PF10192//PF02432//PF00008 Kunitz/Bovine pancreatic trypsin inhibitor domain//Rhodopsin-like GPCR transmembrane domain//Fimbrial, major and minor subunit//EGF-like domain GO:0007155//GO:0007186//GO:0019236 cell adhesion//G-protein coupled receptor signaling pathway//response to pheromone GO:0004867//GO:0005515 serine-type endopeptidase inhibitor activity//protein binding GO:0009289 pilus -- -- Cluster-8309.47947 BF_2 11.00 3.08 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47949 BF_2 869.46 4.82 7828 642925217 XP_008194472.1 2663 8.2e-298 PREDICTED: zinc finger protein 729-like isoform X1 [Tribolium castaneum]>gi|270008760|gb|EFA05208.1| hypothetical protein TcasGA2_TC015347 [Tribolium castaneum] 194761711 XM_001963036.1 87 1.54703e-34 Drosophila ananassae GF15759 (Dana\GF15759), mRNA -- -- -- -- Q9VL13 907 1.4e-95 MOB kinase activator-like 3 OS=Drosophila melanogaster GN=Mob3 PE=2 SV=1 PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus KOG1903 Cell cycle-associated protein Cluster-8309.47951 BF_2 282.46 1.44 8521 642924897 XP_008194088.1 5244 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 1408 1.2e-153 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF06008 Laminin Domain I GO:0030155//GO:0030334//GO:0007165//GO:0045995 regulation of cell adhesion//regulation of cell migration//signal transduction//regulation of embryonic development GO:0005102 receptor binding -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.47952 BF_2 214.89 0.93 9908 642924897 XP_008194088.1 7637 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 2408 1.6e-269 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF06008 Laminin Domain I GO:0007165//GO:0030155//GO:0030334//GO:0045995 signal transduction//regulation of cell adhesion//regulation of cell migration//regulation of embryonic development GO:0005102 receptor binding -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.47953 BF_2 1965.53 45.31 2102 642921619 XP_008192449.1 547 5.1e-53 PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum]>gi|642921621|ref|XP_008192450.1| PREDICTED: nose resistant to fluoxetine protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 293 5.9e-25 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.47954 BF_2 264.00 4.00 3051 546677546 ERL88365.1 2277 1.8e-253 hypothetical protein D910_05752 [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1403 1.7e-153 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613//PF00060//PF06816 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//NOTCH protein GO:0006811//GO:0030154//GO:0007268//GO:0007165 ion transport//cell differentiation//synaptic transmission//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.47956 BF_2 3.00 5.47 289 642924557 XP_008194343.1 147 1.7e-07 PREDICTED: zinc finger protein 600-like [Tribolium castaneum]>gi|270006757|gb|EFA03205.1| hypothetical protein TcasGA2_TC013125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07649//PF06397//PF13465//PF00096 C1-like domain//Desulfoferrodoxin, N-terminal domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0055114 oxidation-reduction process GO:0005506//GO:0046872//GO:0047134 iron ion binding//metal ion binding//protein-disulfide reductase activity -- -- -- -- Cluster-8309.47957 BF_2 10.86 3.92 402 642926860 XP_971810.2 171 3.8e-10 PREDICTED: zinc finger protein 90 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01155//PF13465//PF00096//PF01096//PF00647//PF07649 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//Elongation factor 1 gamma, conserved domain//C1-like domain GO:0006448//GO:0006414//GO:0006464//GO:0006351//GO:0055114 regulation of translational elongation//translational elongation//cellular protein modification process//transcription, DNA-templated//oxidation-reduction process GO:0016151//GO:0047134//GO:0046872//GO:0003676//GO:0003746//GO:0008270 nickel cation binding//protein-disulfide reductase activity//metal ion binding//nucleic acid binding//translation elongation factor activity//zinc ion binding GO:0005840 ribosome -- -- Cluster-8309.47958 BF_2 15.35 1.32 774 861591666 KMQ82837.1 178 1.2e-10 integrase core domain protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47959 BF_2 160.79 8.42 1086 642923928 XP_008193931.1 1196 1.5e-128 PREDICTED: probable serine incorporator isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHV9 744 1.6e-77 Serine incorporator 1 OS=Bos taurus GN=SERINC1 PE=2 SV=1 PF03348 Serine incorporator (Serinc) -- -- -- -- GO:0016020 membrane KOG2592 Tumor differentially expressed (TDE) protein Cluster-8309.47960 BF_2 1186.57 10.94 4823 478255594 ENN75808.1 232 3.9e-16 hypothetical protein YQE_07644, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q86GF7 197 1.8e-13 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF02382 RTX N-terminal domain GO:0009405 pathogenesis GO:0005509 calcium ion binding GO:0005576 extracellular region KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.47962 BF_2 146.00 6.63 1208 546673618 ERL85182.1 650 3.3e-65 hypothetical protein D910_02604, partial [Dendroctonus ponderosae] -- -- -- -- -- K00942 E2.7.4.8, gmk guanylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00942 Q64520 527 2.5e-52 Guanylate kinase OS=Mus musculus GN=Guk1 PE=1 SV=2 PF01926//PF06068//PF01695//PF07728//PF08477//PF00004//PF01637//PF03205//PF00005//PF03193//PF00910//PF00485 50S ribosome-binding GTPase//TIP49 C-terminus//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Ras of Complex, Roc, domain of DAPkinase//ATPase family associated with various cellular activities (AAA)//Archaeal ATPase//Molybdopterin guanine dinucleotide synthesis protein B//ABC transporter//Protein of unknown function, DUF258//RNA helicase//Phosphoribulokinase / Uridine kinase family GO:0008152//GO:0006777//GO:0007264 metabolic process//Mo-molybdopterin cofactor biosynthetic process//small GTPase mediated signal transduction GO:0003723//GO:0005524//GO:0003678//GO:0003924//GO:0016887//GO:0016301//GO:0005525//GO:0003724 RNA binding//ATP binding//DNA helicase activity//GTPase activity//ATPase activity//kinase activity//GTP binding//RNA helicase activity GO:0005657 replication fork KOG0707 Guanylate kinase Cluster-8309.47966 BF_2 121.12 0.56 9338 642937449 XP_008198840.1 454 1.4e-41 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00042//PF00628//PF07127 Globin//PHD-finger//Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872//GO:0005515//GO:0020037//GO:0019825 metal ion binding//protein binding//heme binding//oxygen binding -- -- -- -- Cluster-8309.47967 BF_2 107.65 1.19 4087 478252657 ENN73061.1 1798 8.6e-198 hypothetical protein YQE_10331, partial [Dendroctonus ponderosae] -- -- -- -- -- K10770 ALKBH8 alkylated DNA repair protein alkB homolog 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10770 Q07G10 1262 5.0e-137 Alkylated DNA repair protein alkB homolog 8 OS=Xenopus tropicalis GN=alkbh8 PE=2 SV=2 PF01738//PF08241//PF08168//PF04083//PF01209 Dienelactone hydrolase family//Methyltransferase domain//NUC205 domain//Partial alpha/beta-hydrolase lipase region//ubiE/COQ5 methyltransferase family GO:0008152//GO:0006629 metabolic process//lipid metabolic process GO:0008168//GO:0016787 methyltransferase activity//hydrolase activity GO:0005634 nucleus -- -- Cluster-8309.47968 BF_2 1.00 1.59 295 478260276 ENN80028.1 162 3.1e-09 hypothetical protein YQE_03505, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05495//PF02150//PF13465//PF00096 CHY zinc finger//RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.47970 BF_2 12.90 2.55 499 260810939 XP_002600180.1 164 3.1e-09 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00096//PF13465//PF02150 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0008270//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.47971 BF_2 84.88 0.68 5533 642937245 XP_008198754.1 4816 0.0e+00 PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937247|ref|XP_008198755.1| PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937249|ref|XP_008198756.1| PREDICTED: protocadherin-15 [Tribolium castaneum] 817188676 XM_012433497.1 76 1.42244e-28 PREDICTED: Orussus abietinus protocadherin-15 (LOC105704354), mRNA K16500 PCDH15 protocadherin-15 http://www.genome.jp/dbget-bin/www_bget?ko:K16500 Q8BNA6 730 3.3e-75 Protocadherin Fat 3 OS=Mus musculus GN=Fat3 PE=1 SV=2 PF01272//PF00028//PF00041 Transcription elongation factor, GreA/GreB, C-term//Cadherin domain//Fibronectin type III domain GO:0007156//GO:0032784 homophilic cell adhesion via plasma membrane adhesion molecules//regulation of DNA-templated transcription, elongation GO:0005509//GO:0003677//GO:0005515 calcium ion binding//DNA binding//protein binding GO:0016020 membrane -- -- Cluster-8309.47972 BF_2 390.12 3.39 5100 642937245 XP_008198754.1 6167 0.0e+00 PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937247|ref|XP_008198755.1| PREDICTED: protocadherin-15 [Tribolium castaneum]>gi|642937249|ref|XP_008198756.1| PREDICTED: protocadherin-15 [Tribolium castaneum] 817188676 XM_012433497.1 76 1.31039e-28 PREDICTED: Orussus abietinus protocadherin-15 (LOC105704354), mRNA K16500 PCDH15 protocadherin-15 http://www.genome.jp/dbget-bin/www_bget?ko:K16500 Q8R508 856 7.5e-90 Protocadherin Fat 3 OS=Rattus norvegicus GN=Fat3 PE=1 SV=1 PF00041//PF00028//PF01272 Fibronectin type III domain//Cadherin domain//Transcription elongation factor, GreA/GreB, C-term GO:0007156//GO:0032784 homophilic cell adhesion via plasma membrane adhesion molecules//regulation of DNA-templated transcription, elongation GO:0003677//GO:0005509//GO:0005515 DNA binding//calcium ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.47974 BF_2 1.81 18.34 233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47976 BF_2 177.11 0.95 8120 642924482 XP_008194314.1 3729 0.0e+00 PREDICTED: protein ELYS isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U249 903 4.2e-95 Protein ELYS OS=Xenopus laevis GN=ahctf1 PE=1 SV=1 PF05210 Sprouty protein (Spry) GO:0009966//GO:0007275 regulation of signal transduction//multicellular organismal development -- -- GO:0016020 membrane -- -- Cluster-8309.47977 BF_2 15.29 0.60 1346 642932836 XP_008197006.1 968 5.0e-102 PREDICTED: uncharacterized protein LOC663161 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47978 BF_2 201.35 3.84 2479 270007381 EFA03829.1 1893 5.0e-209 hypothetical protein TcasGA2_TC013944 [Tribolium castaneum] -- -- -- -- -- K19192 SAP130 histone deacetylase complex subunit SAP130 http://www.genome.jp/dbget-bin/www_bget?ko:K19192 Q8BIH0 312 4.4e-27 Histone deacetylase complex subunit SAP130 OS=Mus musculus GN=Sap130 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.47979 BF_2 1516.42 12.61 5316 407731620 AFU25696.1 4540 0.0e+00 Na+,K+ ATPase alpha-subunit 2, partial [Tetraopes tetrophthalmus] 407731619 JQ771527.1 1269 0 Tetraopes tetrophthalmus Na+,K+ ATPase alpha-subunit 2 mRNA, partial cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 2978 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF04565//PF00122 RNA polymerase Rpb2, domain 3//E1-E2 ATPase GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0000166 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//nucleotide binding GO:0005730 nucleolus KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.47983 BF_2 157.46 2.08 3452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47988 BF_2 335.00 9.81 1716 91091920 XP_967150.1 2145 2.1e-238 PREDICTED: 60S ribosomal export protein NMD3 [Tribolium castaneum]>gi|270000793|gb|EEZ97240.1| hypothetical protein TcasGA2_TC011038 [Tribolium castaneum] 194768750 XM_001966439.1 63 7.33283e-22 Drosophila ananassae GF21978 (Dana\GF21978), mRNA K07562 NMD3 nonsense-mediated mRNA decay protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K07562 Q5BLF0 1487 1.7e-163 60S ribosomal export protein NMD3 OS=Danio rerio GN=nmd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2613 NMD protein affecting ribosome stability and mRNA decay Cluster-8309.47989 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47990 BF_2 272.81 5.81 2251 91085843 XP_974961.1 554 8.4e-54 PREDICTED: protein lunapark [Tribolium castaneum]>gi|270010140|gb|EFA06588.1| hypothetical protein TcasGA2_TC009502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1KKR9 362 6.3e-33 Protein lunapark-B OS=Takifugu rubripes GN=lnpb PE=3 SV=1 PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG2846 Predicted membrane protein Cluster-8309.47993 BF_2 75.46 2.58 1513 642921071 XP_008192680.1 188 1.6e-11 PREDICTED: muscle LIM protein Mlp84B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47994 BF_2 21.00 2.56 630 270003490 EEZ99937.1 564 1.6e-55 hypothetical protein TcasGA2_TC002733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DM3 281 4.4e-24 Uncharacterized protein C18orf8 OS=Homo sapiens GN=C18orf8 PE=2 SV=2 PF09280 XPC-binding domain GO:0006281//GO:0043161//GO:0006289 DNA repair//proteasome-mediated ubiquitin-dependent protein catabolic process//nucleotide-excision repair GO:0003684 damaged DNA binding -- -- KOG2377 Uncharacterized conserved protein Cluster-8309.47995 BF_2 1.00 0.44 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47996 BF_2 3.00 32.79 231 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.47998 BF_2 59.00 1.82 1641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04647 Accessory gene regulator B GO:0009372//GO:0009405 quorum sensing//pathogenesis GO:0008233 peptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.4800 BF_2 11.88 0.60 1111 270012890 EFA09338.1 480 1.6e-45 hypothetical protein TcasGA2_TC001664 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02884 Polysaccharide lyase family 8, C-terminal beta-sandwich domain -- -- GO:0016829 lyase activity GO:0005576 extracellular region -- -- Cluster-8309.48002 BF_2 1609.00 77.03 1161 114051842 NP_001040431.1 525 1.0e-50 cyclic AMP-regulated protein [Bombyx mori]>gi|95102866|gb|ABF51374.1| cyclic AMP-regulated protein [Bombyx mori] -- -- -- -- -- -- -- -- -- Q14019 309 4.6e-27 Coactosin-like protein OS=Homo sapiens GN=COTL1 PE=1 SV=3 PF00241 Cofilin/tropomyosin-type actin-binding protein -- -- GO:0003779 actin binding GO:0005622 intracellular -- -- Cluster-8309.48006 BF_2 66.40 1.14 2730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48008 BF_2 246.12 5.20 2268 332375232 AEE62757.1 1178 3.7e-126 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00729 ALG5 dolichyl-phosphate beta-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00729 Q9VLQ1 972 1.2e-103 Dolichyl-phosphate beta-glucosyltransferase OS=Drosophila melanogaster GN=wol PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2977 Glycosyltransferase Cluster-8309.48009 BF_2 186.11 5.09 1817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48011 BF_2 43.62 1.00 2119 642915313 XP_008190567.1 2613 1.4e-292 PREDICTED: dosage compensation regulator isoform X1 [Tribolium castaneum] 617490619 XM_007578097.1 253 2.17863e-127 PREDICTED: Poecilia formosa DEAH (Asp-Glu-Ala-His) box helicase 9 (dhx9), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1880 5.7e-209 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF04408 Helicase associated domain (HA2) -- -- GO:0004386 helicase activity -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.48012 BF_2 39.58 0.57 3202 91088947 XP_973771.1 2775 2.5e-311 PREDICTED: exocyst complex component 3 [Tribolium castaneum]>gi|270012371|gb|EFA08819.1| hypothetical protein TcasGA2_TC006514 [Tribolium castaneum] -- -- -- -- -- K06110 EXOC3, SEC6L1 exocyst complex component 3 http://www.genome.jp/dbget-bin/www_bget?ko:K06110 Q9V8K2 1730 2.1e-191 Exocyst complex component 3 OS=Drosophila melanogaster GN=sec6 PE=2 SV=2 PF05192//PF03283//PF06046 MutS domain III//Pectinacetylesterase//Exocyst complex component Sec6 GO:0006298//GO:0006887 mismatch repair//exocytosis GO:0005524//GO:0030983//GO:0016787 ATP binding//mismatched DNA binding//hydrolase activity GO:0000145 exocyst KOG2286 Exocyst complex subunit SEC6 Cluster-8309.48013 BF_2 171.35 17.93 687 642926077 XP_971220.2 626 1.1e-62 PREDICTED: 39S ribosomal protein L18, mitochondrial [Tribolium castaneum] -- -- -- -- -- K02881 RP-L18, MRPL18, rplR large subunit ribosomal protein L18 http://www.genome.jp/dbget-bin/www_bget?ko:K02881 Q9H0U6 244 9.3e-20 39S ribosomal protein L18, mitochondrial OS=Homo sapiens GN=MRPL18 PE=1 SV=1 PF00861 Ribosomal L18p/L5e family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3333 Mitochondrial/chloroplast ribosomal protein L18 Cluster-8309.48017 BF_2 91.95 1.71 2540 642931650 XP_008196671.1 163 2.1e-08 PREDICTED: death-associated protein kinase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5D014 143 1.8e-07 Protein NATD1 OS=Danio rerio GN=natd1 PE=3 SV=1 PF04558//PF00583//PF13508 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967//GO:0006418 acyl-carrier-protein biosynthetic process//tRNA aminoacylation for protein translation GO:0004812//GO:0008080//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//N-acetyltransferase activity//ATP binding//nucleotide binding GO:0005737 cytoplasm -- -- Cluster-8309.48019 BF_2 197.12 3.37 2732 642929013 XP_008195655.1 1308 3.8e-141 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Tribolium castaneum] 759111195 XM_011357078.1 54 1.18402e-16 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K06125 COQ2 4-hydroxybenzoate polyprenyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06125 Q16QL3 1096 6.0e-118 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Aedes aegypti GN=coq2 PE=3 SV=1 PF01040//PF02366 UbiA prenyltransferase family//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0006493 protein O-linked glycosylation GO:0004659//GO:0000030 prenyltransferase activity//mannosyltransferase activity GO:0000136//GO:0016020//GO:0016021 alpha-1,6-mannosyltransferase complex//membrane//integral component of membrane KOG1381 Para-hydroxybenzoate-polyprenyl transferase Cluster-8309.48023 BF_2 370.47 0.92 17162 642913486 XP_008201031.1 6772 0.0e+00 PREDICTED: histone-lysine N-methyltransferase 2C-like isoform X2 [Tribolium castaneum] 807039419 XM_004534701.2 145 1.94693e-66 PREDICTED: Ceratitis capitata histone-lysine N-methyltransferase trr (LOC101450744), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1972 9.9e-219 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF00856//PF05965//PF07155//PF00628//PF05964 SET domain//F/Y rich C-terminus//ECF-type riboflavin transporter, S component//PHD-finger//F/Y-rich N-terminus -- -- GO:0005515 protein binding GO:0005634//GO:0016020 nucleus//membrane KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.48024 BF_2 126.92 1.12 5015 270010959 EFA07407.1 2173 3.5e-241 protein C kinase 98E-like protein [Tribolium castaneum] 817193422 XM_012416747.1 273 3.966e-138 PREDICTED: Orussus abietinus protein kinase C (LOC105695297), transcript variant X5, mRNA K18050 PRKCE novel protein kinase C epsilon type http://www.genome.jp/dbget-bin/www_bget?ko:K18050 P13678 1797 5.7e-199 Protein kinase C OS=Drosophila melanogaster GN=Pkc98E PE=2 SV=1 PF00130//PF07714//PF07649//PF00628//PF00069//PF00168//PF00433//PF06293 Phorbol esters/diacylglycerol binding domain (C1 domain)//Protein tyrosine kinase//C1-like domain//PHD-finger//Protein kinase domain//C2 domain//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009069//GO:0006468//GO:0016310//GO:0055114//GO:0035556 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0016773//GO:0047134//GO:0004672//GO:0004674 ATP binding//protein binding//phosphotransferase activity, alcohol group as acceptor//protein-disulfide reductase activity//protein kinase activity//protein serine/threonine kinase activity GO:0016020 membrane KOG0694 Serine/threonine protein kinase Cluster-8309.48026 BF_2 456.22 3.80 5312 546680410 ERL90676.1 3620 0.0e+00 hypothetical protein D910_08023 [Dendroctonus ponderosae] 827559853 XM_012695450.1 81 2.26844e-31 PREDICTED: Bombyx mori active breakpoint cluster region-related protein (LOC101736460), transcript variant X3, mRNA -- -- -- -- Q6PAJ1 1290 3.7e-140 Breakpoint cluster region protein OS=Mus musculus GN=Bcr PE=1 SV=3 PF00621//PF07247//PF09036//PF00620//PF00168 RhoGEF domain//Alcohol acetyltransferase//Bcr-Abl oncoprotein oligomerisation domain//RhoGAP domain//C2 domain GO:0043087//GO:0035023//GO:0007165//GO:0042967//GO:0016310//GO:0006066//GO:0009069//GO:0006468 regulation of GTPase activity//regulation of Rho protein signal transduction//signal transduction//acyl-carrier-protein biosynthetic process//phosphorylation//alcohol metabolic process//serine family amino acid metabolic process//protein phosphorylation GO:0004026//GO:0004674//GO:0005089//GO:0005096//GO:0005515 alcohol O-acetyltransferase activity//protein serine/threonine kinase activity//Rho guanyl-nucleotide exchange factor activity//GTPase activator activity//protein binding -- -- -- -- Cluster-8309.48028 BF_2 112.48 1.14 4424 642921136 XP_008192702.1 1068 4.1e-113 PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921138|ref|XP_008192703.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921140|ref|XP_008192704.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921142|ref|XP_008192706.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921144|ref|XP_008192707.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921146|ref|XP_008192708.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921148|ref|XP_008192709.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum]>gi|642921150|ref|XP_008192710.1| PREDICTED: uncharacterized protein LOC664293 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WVB4 224 1.3e-16 Slit homolog 3 protein OS=Mus musculus GN=Slit3 PE=2 SV=2 PF13855//PF13895//PF15050//PF14991 Leucine rich repeat//Immunoglobulin domain//SCIMP protein//Protein melan-A -- -- GO:0005515 protein binding GO:0016021//GO:0001772//GO:0042470//GO:0097197 integral component of membrane//immunological synapse//melanosome//tetraspanin-enriched microdomain -- -- Cluster-8309.48030 BF_2 1170.81 11.16 4674 642915090 XP_008190408.1 1130 2.8e-120 PREDICTED: probable uridine-cytidine kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q9VC99 910 3.8e-96 Probable uridine-cytidine kinase OS=Drosophila melanogaster GN=CG6364 PE=3 SV=1 PF00485//PF09547//PF06414//PF01121//PF02224//PF00437//PF07690//PF00083//PF03810 Phosphoribulokinase / Uridine kinase family//Stage IV sporulation protein A (spore_IV_A)//Zeta toxin//Dephospho-CoA kinase//Cytidylate kinase//Type II/IV secretion system protein//Major Facilitator Superfamily//Sugar (and other) transporter//Importin-beta N-terminal domain GO:0008152//GO:0006206//GO:0043934//GO:0055085//GO:0015940//GO:0006139//GO:0006810//GO:0006886//GO:0015937 metabolic process//pyrimidine nucleobase metabolic process//sporulation//transmembrane transport//pantothenate biosynthetic process//nucleobase-containing compound metabolic process//transport//intracellular protein transport//coenzyme A biosynthetic process GO:0022857//GO:0008536//GO:0004140//GO:0005524//GO:0016301//GO:0016887//GO:0004127 transmembrane transporter activity//Ran GTPase binding//dephospho-CoA kinase activity//ATP binding//kinase activity//ATPase activity//cytidylate kinase activity GO:0016021 integral component of membrane KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.48031 BF_2 11.17 0.47 1279 91078976 XP_974454.1 252 5.0e-19 PREDICTED: heparan-alpha-glucosaminide N-acetyltransferase [Tribolium castaneum]>gi|270003686|gb|EFA00134.1| hypothetical protein TcasGA2_TC002950 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48033 BF_2 475.47 13.61 1749 478260919 ENN80542.1 1144 2.5e-122 hypothetical protein YQE_03036, partial [Dendroctonus ponderosae]>gi|546684164|gb|ERL93869.1| hypothetical protein D910_11155 [Dendroctonus ponderosae] -- -- -- -- -- K11687 ADPRHL2 poly(ADP-ribose) glycohydrolase ARH3 http://www.genome.jp/dbget-bin/www_bget?ko:K11687 Q8CG72 584 8.9e-59 Poly(ADP-ribose) glycohydrolase ARH3 OS=Mus musculus GN=Adprhl2 PE=1 SV=1 PF01051 Initiator Replication protein GO:0006260//GO:0006270 DNA replication//DNA replication initiation GO:0003887 DNA-directed DNA polymerase activity GO:0005727//GO:0042575 extrachromosomal circular DNA//DNA polymerase complex -- -- Cluster-8309.48034 BF_2 27.64 0.37 3427 91090264 XP_970269.1 366 8.1e-32 PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934841|ref|XP_008197832.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934843|ref|XP_008197833.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934845|ref|XP_008197834.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|270013784|gb|EFA10232.1| hypothetical protein TcasGA2_TC012429 [Tribolium castaneum] -- -- -- -- -- K10666 RNF5 E3 ubiquitin-protein ligase RNF5 http://www.genome.jp/dbget-bin/www_bget?ko:K10666 Q5ZIR9 302 8.8e-26 E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus GN=RNF185 PE=2 SV=1 PF00219//PF12678//PF12861//PF13639 Insulin-like growth factor binding protein//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain GO:0001558//GO:0016567 regulation of cell growth//protein ubiquitination GO:0046872//GO:0008270//GO:0005515//GO:0004842//GO:0005520 metal ion binding//zinc ion binding//protein binding//ubiquitin-protein transferase activity//insulin-like growth factor binding GO:0005576//GO:0016942//GO:0005680 extracellular region//insulin-like growth factor binding protein complex//anaphase-promoting complex KOG0823 Predicted E3 ubiquitin ligase Cluster-8309.48035 BF_2 2.00 0.32 546 391339448 XP_003744061.1 161 7.6e-09 PREDICTED: uncharacterized protein LOC100905681 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006090//GO:0071436//GO:0006814//GO:0006525//GO:0006560 pyruvate metabolic process//sodium ion export//sodium ion transport//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.48036 BF_2 1033.59 21.98 2254 478251961 ENN72399.1 2164 1.7e-240 hypothetical protein YQE_11033, partial [Dendroctonus ponderosae] -- -- -- -- -- K01412 PMPCA, MAS2 mitochondrial-processing peptidase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01412 Q0P5M8 1272 1.9e-138 Mitochondrial-processing peptidase subunit alpha OS=Bos taurus GN=PMPCA PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2067 Mitochondrial processing peptidase, alpha subunit Cluster-8309.48038 BF_2 2.00 0.31 554 546684446 ERL94085.1 209 2.1e-14 hypothetical protein D910_11367 [Dendroctonus ponderosae] -- -- -- -- -- K01412 PMPCA, MAS2 mitochondrial-processing peptidase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01412 P20069 151 4.6e-09 Mitochondrial-processing peptidase subunit alpha OS=Rattus norvegicus GN=Pmpca PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2067 Mitochondrial processing peptidase, alpha subunit Cluster-8309.48040 BF_2 168.61 1.62 4642 642915162 XP_008190500.1 1424 2.3e-154 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02562 149 6.5e-08 Myosin heavy chain, skeletal muscle (Fragments) OS=Oryctolagus cuniculus PE=1 SV=2 PF02135 TAZ zinc finger GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0008270//GO:0003712//GO:0004402 zinc ion binding//transcription cofactor activity//histone acetyltransferase activity GO:0000123//GO:0005667//GO:0005634 histone acetyltransferase complex//transcription factor complex//nucleus -- -- Cluster-8309.48042 BF_2 55.60 1.97 1465 270014289 EFA10737.1 225 7.7e-16 armadillo-1 [Tribolium castaneum] 642934620 XM_008199519.1 68 1.03647e-24 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 Q17GS9 128 5.6e-06 Armadillo segment polarity protein OS=Aedes aegypti GN=arm PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48043 BF_2 86.30 2.94 1515 270014289 EFA10737.1 642 3.5e-64 armadillo-1 [Tribolium castaneum] 642934620 XM_008199519.1 158 9.9944e-75 PREDICTED: Tribolium castaneum armadillo segment polarity protein-like (LOC659291), transcript variant X1, mRNA K02105 CTNNB1 catenin beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02105 P18824 430 5.6e-41 Armadillo segment polarity protein OS=Drosophila melanogaster GN=arm PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48044 BF_2 135.00 33.19 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48047 BF_2 122.43 3.54 1735 642923022 XP_008200499.1 968 6.4e-102 PREDICTED: U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62377 498 8.3e-49 U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 OS=Mus musculus GN=Zrsr2 PE=2 SV=1 PF00076//PF00642 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- KOG2202 U2 snRNP splicing factor, small subunit, and related proteins Cluster-8309.48048 BF_2 326.00 68.18 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48050 BF_2 301.00 4.52 3073 189234519 XP_001813478.1 630 1.8e-62 PREDICTED: BRISC complex subunit Abro1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TCJ1 271 3.1e-22 BRISC complex subunit Abro1 OS=Mus musculus GN=Fam175b PE=2 SV=1 PF09162 Tap, RNA-binding GO:0006406 mRNA export from nucleus GO:0003723 RNA binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.48051 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48053 BF_2 697.74 6.11 5067 91082203 XP_972014.1 3609 0.0e+00 PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922206|ref|XP_008193062.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922209|ref|XP_008193063.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|270007229|gb|EFA03677.1| hypothetical protein TcasGA2_TC013779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02466 665 1.0e-67 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF07714//PF03139//PF00069//PF05676 Protein tyrosine kinase//Vanadium/alternative nitrogenase delta subunit//Protein kinase domain//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0015992//GO:0055114//GO:0006118//GO:0006814//GO:0006468//GO:0009399//GO:0006120//GO:0006807//GO:0006744//GO:0016310//GO:0019337 proton transport//oxidation-reduction process//obsolete electron transport//sodium ion transport//protein phosphorylation//nitrogen fixation//mitochondrial electron transport, NADH to ubiquinone//nitrogen compound metabolic process//ubiquinone biosynthetic process//phosphorylation//tetrachloroethylene catabolic process GO:0016163//GO:0008137//GO:0000166//GO:0005524//GO:0004672//GO:0003954 nitrogenase activity//NADH dehydrogenase (ubiquinone) activity//nucleotide binding//ATP binding//protein kinase activity//NADH dehydrogenase activity GO:0016610//GO:0005739 nitrogenase complex//mitochondrion KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.48054 BF_2 99.08 4.89 1135 642912575 XP_008200916.1 674 5.2e-68 PREDICTED: guanine nucleotide-releasing factor 2 isoform X4 [Tribolium castaneum] -- -- -- -- -- K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 325 6.3e-29 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF03425 Carbohydrate binding domain (family 11) GO:0030245//GO:0005982//GO:0005985 cellulose catabolic process//starch metabolic process//sucrose metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.48055 BF_2 211.03 2.03 4628 642936421 XP_008198427.1 2180 4.9e-242 PREDICTED: 5-hydroxytryptamine receptor 1 [Tribolium castaneum] 827537400 XM_012691584.1 74 1.5371e-27 PREDICTED: Bombyx mori 5-hydroxytryptamine receptor 1-like (LOC101742917), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 P20905 1148 9.4e-124 5-hydroxytryptamine receptor 1 OS=Drosophila melanogaster GN=5-HT7 PE=2 SV=1 PF12822//PF06072//PF00001//PF03839 Protein of unknown function (DUF3816)//Alphaherpesvirus tegument protein US9//7 transmembrane receptor (rhodopsin family)//Translocation protein Sec62 GO:0015031//GO:0007186//GO:0006810 protein transport//G-protein coupled receptor signaling pathway//transport GO:0008565//GO:0005215//GO:0004930 protein transporter activity//transporter activity//G-protein coupled receptor activity GO:0019033//GO:0016021 viral tegument//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.48056 BF_2 146.25 1.40 4656 642936421 XP_008198427.1 2180 5.0e-242 PREDICTED: 5-hydroxytryptamine receptor 1 [Tribolium castaneum] 827537400 XM_012691584.1 74 1.54648e-27 PREDICTED: Bombyx mori 5-hydroxytryptamine receptor 1-like (LOC101742917), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 P20905 1148 9.5e-124 5-hydroxytryptamine receptor 1 OS=Drosophila melanogaster GN=5-HT7 PE=2 SV=1 PF03839//PF12822//PF06072//PF00001 Translocation protein Sec62//Protein of unknown function (DUF3816)//Alphaherpesvirus tegument protein US9//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0015031//GO:0006810 G-protein coupled receptor signaling pathway//protein transport//transport GO:0008565//GO:0004930//GO:0005215 protein transporter activity//G-protein coupled receptor activity//transporter activity GO:0016021//GO:0019033 integral component of membrane//viral tegument KOG3656 FOG: 7 transmembrane receptor Cluster-8309.48057 BF_2 23.57 0.37 2982 91088439 XP_968151.1 419 5.0e-38 PREDICTED: uncharacterized protein LOC656533 [Tribolium castaneum]>gi|270011749|gb|EFA08197.1| hypothetical protein TcasGA2_TC005824 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48058 BF_2 155.26 2.11 3360 189235679 XP_971393.2 409 8.2e-37 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48060 BF_2 161.00 3.89 2018 -- -- -- -- -- 56044569 AC152925.1 37 2.45667e-07 Tribolium castaneum BAC T.cast_C17P12 (Clemson University Genomics Institute Tribolium castaneum BAC Library (Red Flour Beetle)) complete sequence -- -- -- -- -- -- -- -- PF01273 LBP / BPI / CETP family, N-terminal domain -- -- GO:0008289 lipid binding -- -- -- -- Cluster-8309.48062 BF_2 728.24 10.82 3103 91091282 XP_966431.1 2214 3.8e-246 PREDICTED: rab5 GDP/GTP exchange factor isoform X1 [Tribolium castaneum]>gi|270013085|gb|EFA09533.1| hypothetical protein TcasGA2_TC011637 [Tribolium castaneum] 642936531 XM_970650.3 233 4.20535e-116 PREDICTED: Tribolium castaneum rab5 GDP/GTP exchange factor (LOC658256), transcript variant X2, mRNA -- -- -- -- Q9JM13 745 3.4e-77 Rab5 GDP/GTP exchange factor OS=Mus musculus GN=Rabgef1 PE=1 SV=1 PF01754 A20-like zinc finger -- -- GO:0003677//GO:0005488//GO:0008270 DNA binding//binding//zinc ion binding -- -- KOG2319 Vacuolar assembly/sorting protein VPS9 Cluster-8309.48064 BF_2 327.01 4.54 3298 642914971 XP_008190464.1 2176 1.0e-241 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 1.41247e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 392 3.1e-36 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF00322//PF01585//PF07823//PF01805//PF06703 Endothelin family//G-patch domain//Cyclic phosphodiesterase-like protein//Surp module//Microsomal signal peptidase 25 kDa subunit (SPC25) GO:0019229//GO:0006465//GO:0006396 regulation of vasoconstriction//signal peptide processing//RNA processing GO:0003723//GO:0008233//GO:0003676//GO:0004112 RNA binding//peptidase activity//nucleic acid binding//cyclic-nucleotide phosphodiesterase activity GO:0016021//GO:0005787//GO:0005576 integral component of membrane//signal peptidase complex//extracellular region -- -- Cluster-8309.48065 BF_2 121.37 1.76 3177 642914971 XP_008190464.1 1011 1.2e-106 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 1.36008e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 392 3.0e-36 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF01585//PF00322//PF06703//PF05680 G-patch domain//Endothelin family//Microsomal signal peptidase 25 kDa subunit (SPC25)//ATP synthase E chain GO:0006465//GO:0019229//GO:0015986//GO:0015992 signal peptide processing//regulation of vasoconstriction//ATP synthesis coupled proton transport//proton transport GO:0015078//GO:0003676//GO:0008233 hydrogen ion transmembrane transporter activity//nucleic acid binding//peptidase activity GO:0016021//GO:0000276//GO:0005576//GO:0005787 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//extracellular region//signal peptidase complex -- -- Cluster-8309.48067 BF_2 4.75 0.38 817 741829513 AJA91072.1 182 4.2e-11 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06363//PF15681 Picornaviridae P3A protein//Lymphocyte activation family X GO:0051249//GO:0006955 regulation of lymphocyte activation//immune response -- -- GO:0019012 virion -- -- Cluster-8309.48071 BF_2 229.00 1.76 5730 642914658 XP_008190303.1 1363 3.3e-147 PREDICTED: glycine N-acyltransferase [Tribolium castaneum]>gi|270001445|gb|EEZ97892.1| hypothetical protein TcasGA2_TC000274 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13302//PF13673//PF08445//PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.48072 BF_2 1631.96 42.81 1882 91090214 XP_967924.1 1392 4.7e-151 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q9HAW9 588 3.3e-59 UDP-glucuronosyltransferase 1-8 OS=Homo sapiens GN=UGT1A8 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.48075 BF_2 12.00 1.85 559 157127404 XP_001654963.1 398 2.6e-36 AAEL002228-PA [Aedes aegypti]>gi|108882398|gb|EAT46623.1| AAEL002228-PA [Aedes aegypti] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 337 1.2e-30 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- GO:0003824 catalytic activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48077 BF_2 42.00 4.74 658 478252126 ENN72557.1 261 2.3e-20 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48078 BF_2 60.00 2.86 1164 478252125 ENN72556.1 744 4.0e-76 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 519 2.0e-51 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48080 BF_2 28.00 3.03 674 546672885 ERL84608.1 649 2.4e-65 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 551 2.3e-55 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00107 Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48085 BF_2 21.00 6.08 431 755966256 XP_011305442.1 367 7.8e-33 PREDICTED: fatty acid synthase-like [Fopius arisanus]>gi|755966259|ref|XP_011305443.1| PREDICTED: fatty acid synthase-like [Fopius arisanus] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 284 1.3e-24 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48087 BF_2 88.01 1.02 3881 645008238 XP_008203901.1 1419 7.2e-154 PREDICTED: fatty acid synthase-like [Nasonia vitripennis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 1101 2.2e-118 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00107//PF00106//PF14604//PF00975//PF00018 Zinc-binding dehydrogenase//short chain dehydrogenase//Variant SH3 domain//Thioesterase domain//SH3 domain GO:0055114//GO:0009058//GO:0008152 oxidation-reduction process//biosynthetic process//metabolic process GO:0005515//GO:0016491//GO:0016788 protein binding//oxidoreductase activity//hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48093 BF_2 9.00 0.49 1058 478250393 ENN70888.1 757 1.1e-77 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 614 1.8e-62 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 PF06872 EspG protein GO:0009405//GO:0006508 pathogenesis//proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48095 BF_2 8.22 1.10 599 478252126 ENN72557.1 280 1.3e-22 hypothetical protein YQE_10897, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.481 BF_2 4.65 0.33 875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48100 BF_2 3.00 5.35 290 641675408 XP_008187029.1 225 1.5e-16 PREDICTED: fatty acid synthase [Acyrthosiphon pisum]>gi|641675410|ref|XP_008187030.1| PREDICTED: fatty acid synthase [Acyrthosiphon pisum] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12785 168 2.5e-11 Fatty acid synthase OS=Rattus norvegicus GN=Fasn PE=1 SV=3 PF10174 RIM-binding protein of the cytomatrix active zone -- -- -- -- GO:0048786 presynaptic active zone KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48105 BF_2 2.06 0.43 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48108 BF_2 399.43 6.64 2805 91093897 XP_969153.1 2630 2.0e-294 PREDICTED: tyrosine-protein kinase shark [Tribolium castaneum]>gi|270014537|gb|EFA10985.1| hypothetical protein TcasGA2_TC004153 [Tribolium castaneum] -- -- -- -- -- K17512 SHARK tyrosine-protein kinase shark  http://www.genome.jp/dbget-bin/www_bget?ko:K17512 P53356 785 7.1e-82 Tyrosine-protein kinase HTK16 OS=Hydra vulgaris GN=HTK16 PE=2 SV=1 PF00023//PF00069//PF13606//PF07714 Ankyrin repeat//Protein kinase domain//Ankyrin repeat//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524//GO:0004713 protein binding//protein kinase activity//ATP binding//protein tyrosine kinase activity -- -- -- -- Cluster-8309.48109 BF_2 31.57 0.67 2258 91093897 XP_969153.1 1901 5.4e-210 PREDICTED: tyrosine-protein kinase shark [Tribolium castaneum]>gi|270014537|gb|EFA10985.1| hypothetical protein TcasGA2_TC004153 [Tribolium castaneum] -- -- -- -- -- K17512 SHARK tyrosine-protein kinase shark  http://www.genome.jp/dbget-bin/www_bget?ko:K17512 Q24145 780 2.2e-81 Tyrosine-protein kinase shark OS=Drosophila melanogaster GN=shark PE=2 SV=2 PF00069//PF00023//PF07714//PF13606 Protein kinase domain//Ankyrin repeat//Protein tyrosine kinase//Ankyrin repeat GO:0006468//GO:0016310 protein phosphorylation//phosphorylation GO:0004672//GO:0005515//GO:0000166//GO:0005524 protein kinase activity//protein binding//nucleotide binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.48112 BF_2 120.72 26.71 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48114 BF_2 343.75 1.35 10949 197276678 NP_001127849.1 4725 0.0e+00 patched [Tribolium castaneum]>gi|270015128|gb|EFA11576.1| patched [Tribolium castaneum] 197276677 NM_001134377.1 723 0 Tribolium castaneum patched (Ptc), mRNA K15013 ACSBG long-chain-fatty-acid--CoA ligase ACSBG http://www.genome.jp/dbget-bin/www_bget?ko:K15013 P18502 2167 1.5e-241 Protein patched OS=Drosophila melanogaster GN=ptc PE=2 SV=2 PF16499//PF03572//PF02460//PF02116//PF00501//PF08941 Alpha galactosidase A//Peptidase family S41//Patched family//Fungal pheromone mating factor STE2 GPCR//AMP-binding enzyme//USP8 interacting GO:0007165//GO:0007606//GO:0005975//GO:0007186//GO:0016567//GO:0008152//GO:0019236//GO:0006508 signal transduction//sensory perception of chemical stimulus//carbohydrate metabolic process//G-protein coupled receptor signaling pathway//protein ubiquitination//metabolic process//response to pheromone//proteolysis GO:0008158//GO:0031386//GO:0004553//GO:0008236//GO:0004932//GO:0016881//GO:0003824 hedgehog receptor activity//protein tag//hydrolase activity, hydrolyzing O-glycosyl compounds//serine-type peptidase activity//mating-type factor pheromone receptor activity//acid-amino acid ligase activity//catalytic activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1935 Membrane protein Patched/PTCH Cluster-8309.48115 BF_2 28.00 3.50 622 195432162 XP_002064095.1 211 1.4e-14 GK19985 [Drosophila willistoni]>gi|194160180|gb|EDW75081.1| GK19985 [Drosophila willistoni] -- -- -- -- -- K01372 E3.4.22.40, pepC bleomycin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01372 -- -- -- -- PF03051 Peptidase C1-like family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.48118 BF_2 11.98 0.78 928 817053041 XP_012259845.1 528 3.6e-51 PREDICTED: insulin-like receptor [Athalia rosae] -- -- -- -- -- K04527 INSR insulin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04527 O02466 403 4.6e-38 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF00757 Furin-like cysteine rich region GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0004714 ATP binding//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.48119 BF_2 531.31 5.76 4146 91084075 XP_967986.1 1341 8.6e-145 PREDICTED: regucalcin [Tribolium castaneum]>gi|270006685|gb|EFA03133.1| hypothetical protein TcasGA2_TC013045 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q9I923 524 1.9e-51 Regucalcin OS=Gallus gallus GN=RGN PE=2 SV=1 -- -- GO:0050790 regulation of catalytic activity GO:0030234//GO:0005509 enzyme regulator activity//calcium ion binding -- -- -- -- Cluster-8309.48121 BF_2 1296.92 16.07 3663 642918801 XP_008191591.1 1384 7.8e-150 PREDICTED: acyl-CoA:lysophosphatidylglycerol acyltransferase 1 [Tribolium castaneum]>gi|270005684|gb|EFA02132.1| hypothetical protein TcasGA2_TC007781 [Tribolium castaneum] -- -- -- -- -- K13514 LPGAT1 lysophosphatidylglycerol acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13514 Q92604 758 1.2e-78 Acyl-CoA:lysophosphatidylglycerol acyltransferase 1 OS=Homo sapiens GN=LPGAT1 PE=1 SV=1 PF01553 Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups -- -- KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.48122 BF_2 125.23 1.96 2964 478261325 ENN80741.1 3369 0.0e+00 hypothetical protein YQE_02849, partial [Dendroctonus ponderosae] 759040950 XM_011330978.1 45 1.29504e-11 PREDICTED: Cerapachys biroi UPF0378 protein KIAA0100 (LOC105274669), transcript variant X2, mRNA -- -- -- -- Q5SYL3 1379 9.9e-151 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 PF02601 Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG1910 Uncharacterized conserved protein Cluster-8309.48123 BF_2 80.38 4.26 1077 642933143 XP_008197274.1 1612 8.4e-177 PREDICTED: UPF0378 protein KIAA0100 [Tribolium castaneum]>gi|270011425|gb|EFA07873.1| hypothetical protein TcasGA2_TC005447 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14667 735 1.7e-76 Protein KIAA0100 OS=Homo sapiens GN=KIAA0100 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1910 Uncharacterized conserved protein Cluster-8309.48124 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48126 BF_2 147.95 3.53 2041 -- -- -- -- -- 85822206 DQ295882.1 47 6.86098e-13 Glossina morsitans morsitans prophenol oxidase activating enzyme precursor protein (PPAE) mRNA, complete cds -- -- -- -- -- -- -- -- PF13631 Cytochrome b(N-terminal)/b6/petB GO:0006118 obsolete electron transport GO:0009055//GO:0016491 electron carrier activity//oxidoreductase activity GO:0016020 membrane -- -- Cluster-8309.48127 BF_2 42.00 2.33 1042 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48128 BF_2 17.05 0.38 2150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48129 BF_2 4.00 0.75 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48132 BF_2 3.51 0.51 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48133 BF_2 9.00 0.58 932 31872149 AAP59456.1 1039 2.0e-110 cathepsin B precursor [Araneus ventricosus] 505842615 XM_004614756.1 50 6.60354e-15 PREDICTED: Sorex araneus cathepsin B (CTSB), mRNA K01363 CTSB cathepsin B http://www.genome.jp/dbget-bin/www_bget?ko:K01363 P07688 952 1.0e-101 Cathepsin B OS=Bos taurus GN=CTSB PE=1 SV=5 PF08127//PF03051//PF00112 Peptidase family C1 propeptide//Peptidase C1-like family//Papain family cysteine protease GO:0006508//GO:0050790 proteolysis//regulation of catalytic activity GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.48134 BF_2 83.00 2.44 1712 817208960 XP_012280514.1 1282 2.5e-138 PREDICTED: glycoprotein endo-alpha-1,2-mannosidase [Orussus abietinus] -- -- -- -- -- K15538 MANEA glycoprotein endo-alpha-1,2-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K15538 Q5GF25 916 2.8e-97 Glycoprotein endo-alpha-1,2-mannosidase OS=Rattus norvegicus GN=Manea PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48135 BF_2 41.38 0.77 2526 642936826 XP_008197806.1 2492 1.8e-278 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [Tribolium castaneum]>gi|270000937|gb|EEZ97384.1| hypothetical protein TcasGA2_TC011210 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 1889 6.1e-210 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00628//PF00622//PF00130 PHD-finger//SPRY domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.48137 BF_2 145.33 6.28 1255 546676804 ERL87750.1 647 7.7e-65 hypothetical protein D910_05139 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 B4F753 267 3.7e-22 Monoacylglycerol lipase ABHD12 OS=Xenopus tropicalis GN=abhd12 PE=2 SV=1 PF00975//PF01764//PF02230//PF07859//PF14993 Thioesterase domain//Lipase (class 3)//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Neuropeptide S precursor protein GO:0009058//GO:0006629//GO:0007218//GO:0008152 biosynthetic process//lipid metabolic process//neuropeptide signaling pathway//metabolic process GO:0016787//GO:0016788 hydrolase activity//hydrolase activity, acting on ester bonds GO:0005576 extracellular region -- -- Cluster-8309.48139 BF_2 43.36 3.15 863 642931770 XP_008196721.1 672 6.7e-68 PREDICTED: cytohesin-1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q9QX11 460 1.1e-44 Cytohesin-1 OS=Mus musculus GN=Cyth1 PE=1 SV=2 PF01466//PF01369 Skp1 family, dimerisation domain//Sec7 domain GO:0043087//GO:0006511//GO:0032012 regulation of GTPase activity//ubiquitin-dependent protein catabolic process//regulation of ARF protein signal transduction GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.48140 BF_2 198.46 4.22 2255 642931766 XP_008196719.1 2049 3.7e-227 PREDICTED: cytohesin-1 isoform X2 [Tribolium castaneum] 676429235 XM_009047286.1 185 1.46768e-89 Lottia gigantea hypothetical protein partial mRNA K18441 CYTH cytohesin http://www.genome.jp/dbget-bin/www_bget?ko:K18441 Q15438 1356 3.5e-148 Cytohesin-1 OS=Homo sapiens GN=CYTH1 PE=1 SV=1 PF01369//PF11525 Sec7 domain//Copper resistance protein K GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086//GO:0046872 ARF guanyl-nucleotide exchange factor activity//metal ion binding -- -- KOG0930 Guanine nucleotide exchange factor Cytohesin, contains PH and Sec7 domains Cluster-8309.48143 BF_2 529.03 5.28 4476 478258212 ENN78341.1 2330 1.9e-259 hypothetical protein YQE_05143, partial [Dendroctonus ponderosae]>gi|546677008|gb|ERL87924.1| hypothetical protein D910_05312 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q4R7U0 1006 2.7e-107 Transmembrane channel-like protein 7 OS=Macaca fascicularis GN=TMC7 PE=2 SV=1 PF08686//PF07810//PF16794 PLAC (protease and lacunin) domain//TMC domain//Fibronectin-III type domain -- -- GO:0008233//GO:0005515 peptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.48144 BF_2 311.35 2.32 5910 642929812 XP_008195986.1 1599 1.5e-174 PREDICTED: myb-related protein B isoform X2 [Tribolium castaneum] 817200908 XM_012420764.1 89 9.01947e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 1.1e-44 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.48145 BF_2 678.15 5.82 5160 642929812 XP_008195986.1 1980 8.5e-219 PREDICTED: myb-related protein B isoform X2 [Tribolium castaneum] 657582350 XM_008297008.1 122 3.55842e-54 PREDICTED: Stegastes partitus v-myb avian myeloblastosis viral oncogene homolog (myb), mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 Q08759 683 8.7e-70 Transcriptional activator Myb OS=Xenopus laevis GN=myb PE=2 SV=1 PF16517//PF09111 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain//SLIDE GO:0007165//GO:0006338 signal transduction//chromatin remodeling GO:0003676//GO:0005524//GO:0016818 nucleic acid binding//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0005634 nucleus KOG0048 Transcription factor, Myb superfamily Cluster-8309.48146 BF_2 166.64 1.61 4607 642918821 XP_972786.2 1179 5.8e-126 PREDICTED: TNF receptor-associated factor 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 317 2.1e-27 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF06009//PF02176 Acyltransferase family//Laminin Domain II//TRAF-type zinc finger GO:0007155 cell adhesion GO:0016747//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- -- -- Cluster-8309.48147 BF_2 1.00 0.90 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4815 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48150 BF_2 8.86 0.42 1167 642914188 XP_008201581.1 392 2.7e-35 PREDICTED: uncharacterized protein LOC661670 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09064 Thrombomodulin like fifth domain, EGF-like GO:0007165 signal transduction GO:0004888 transmembrane signaling receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.48152 BF_2 6.00 4.88 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48153 BF_2 206.86 1.35 6703 642921311 XP_008192814.1 1092 1.0e-115 PREDICTED: venom acid phosphatase Acph-1-like [Tribolium castaneum]>gi|270006249|gb|EFA02697.1| hypothetical protein TcasGA2_TC008419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLY5 653 3.4e-66 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328//PF08052//PF02367 Histidine phosphatase superfamily (branch 2)//PyrBI operon leader peptide//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0002949//GO:0006771//GO:0019856//GO:0019497 tRNA threonylcarbamoyladenosine modification//riboflavin metabolic process//pyrimidine nucleobase biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.48154 BF_2 53.47 0.35 6640 642921311 XP_008192814.1 1092 1.0e-115 PREDICTED: venom acid phosphatase Acph-1-like [Tribolium castaneum]>gi|270006249|gb|EFA02697.1| hypothetical protein TcasGA2_TC008419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLY5 653 3.4e-66 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF02367//PF08052//PF00328 Threonylcarbamoyl adenosine biosynthesis protein TsaE//PyrBI operon leader peptide//Histidine phosphatase superfamily (branch 2) GO:0002949//GO:0006771//GO:0019856//GO:0019497 tRNA threonylcarbamoyladenosine modification//riboflavin metabolic process//pyrimidine nucleobase biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.48156 BF_2 37.00 3.25 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48157 BF_2 10.19 0.47 1195 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48160 BF_2 36.36 1.04 1745 755939885 XP_011297929.1 794 9.7e-82 PREDICTED: NHS-like protein 1 isoform X1 [Fopius arisanus] -- -- -- -- -- K00750 GYG1, GYG2 glycogenin glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00750 Q9R062 762 2.0e-79 Glycogenin-1 OS=Mus musculus GN=Gyg1 PE=1 SV=3 PF11051//PF01501 Mannosyltransferase putative//Glycosyl transferase family 8 GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1950 Glycosyl transferase, family 8 - glycogenin Cluster-8309.48165 BF_2 208.68 8.12 1362 546679304 ERL89791.1 571 5.4e-56 hypothetical protein D910_07152 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03188 Eukaryotic cytochrome b561 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48169 BF_2 1.24 0.51 388 546675359 ERL86569.1 333 6.1e-29 hypothetical protein D910_03976 [Dendroctonus ponderosae] -- -- -- -- -- K12345 SRD5A3 3-oxo-5-alpha-steroid 4-dehydrogenase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12345 Q9VLP9 204 2.3e-15 Polyprenol reductase OS=Drosophila melanogaster GN=CG7840 PE=2 SV=1 PF02544 3-oxo-5-alpha-steroid 4-dehydrogenase GO:0006629 lipid metabolic process GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG1640 Predicted steroid reductase Cluster-8309.48177 BF_2 367.46 16.68 1209 642913075 XP_008201379.1 1055 3.6e-112 PREDICTED: disks large 1 tumor suppressor protein isoform X3 [Tribolium castaneum] 642913074 XM_008203157.1 285 1.99642e-145 PREDICTED: Tribolium castaneum disks large 1 tumor suppressor protein (LOC663521), transcript variant X3, mRNA K12076 DLG1 disks large protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12076 P31007 354 2.9e-32 Disks large 1 tumor suppressor protein OS=Drosophila melanogaster GN=dlg1 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0708 Membrane-associated guanylate kinase MAGUK (contains PDZ, SH3, HOOK and GUK domains) Cluster-8309.48180 BF_2 64.00 0.97 3046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48182 BF_2 399.26 2.24 7752 91080495 XP_971019.1 7430 0.0e+00 PREDICTED: ectopic P granules protein 5 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IEK6 2377 4.9e-266 Ectopic P granules protein 5 homolog OS=Aedes aegypti GN=AAEL009648 PE=3 SV=1 PF12422//PF05493 Condensin II non structural maintenance of chromosomes subunit//ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0005634//GO:0033179 nucleus//proton-transporting V-type ATPase, V0 domain KOG3622 Uncharacterized conserved protein Cluster-8309.48184 BF_2 13.93 0.76 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48185 BF_2 509.10 8.97 2661 642921967 XP_008192964.1 947 2.7e-99 PREDICTED: protein painting of fourth isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W123 294 5.8e-25 Protein painting of fourth OS=Drosophila melanogaster GN=Pof PE=1 SV=1 PF00076//PF01757 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Acyltransferase family -- -- GO:0016747//GO:0003676 transferase activity, transferring acyl groups other than amino-acyl groups//nucleic acid binding -- -- -- -- Cluster-8309.48188 BF_2 597.17 3.79 6877 478249793 ENN70300.1 1026 4.8e-108 hypothetical protein YQE_12811, partial [Dendroctonus ponderosae] 642934382 XM_962183.2 94 1.74455e-38 PREDICTED: Tribolium castaneum fibroblast growth factor receptor-like 1 (LOC655623), mRNA K15279 SLC35C1, FUCT1 solute carrier family 35 (GDP-fucose transporter), member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K15279 Q9VHT4 606 9.9e-61 GDP-fucose transporter 1 OS=Drosophila melanogaster GN=nac PE=1 SV=1 PF03121//PF03030//PF13895//PF00892//PF06667 Herpesviridae UL52/UL70 DNA primase//Inorganic H+ pyrophosphatase//Immunoglobulin domain//EamA-like transporter family//Phage shock protein B GO:0015992//GO:0006355//GO:0006269//GO:0006260//GO:0006119//GO:0006351//GO:0009271 proton transport//regulation of transcription, DNA-templated//DNA replication, synthesis of RNA primer//DNA replication//oxidative phosphorylation//transcription, DNA-templated//phage shock GO:0005515//GO:0009678//GO:0004427//GO:0003896 protein binding//hydrogen-translocating pyrophosphatase activity//inorganic diphosphatase activity//DNA primase activity GO:0005730//GO:0016020//GO:0016021//GO:0005657 nucleolus//membrane//integral component of membrane//replication fork KOG1442 GDP-fucose transporter Cluster-8309.48189 BF_2 94.87 3.69 1363 478249807 ENN70314.1 757 1.5e-77 hypothetical protein YQE_12825, partial [Dendroctonus ponderosae]>gi|546682872|gb|ERL92758.1| hypothetical protein D910_10067 [Dendroctonus ponderosae] -- -- -- -- -- K15279 SLC35C1, FUCT1 solute carrier family 35 (GDP-fucose transporter), member C1 http://www.genome.jp/dbget-bin/www_bget?ko:K15279 Q9VHT4 484 2.7e-47 GDP-fucose transporter 1 OS=Drosophila melanogaster GN=nac PE=1 SV=1 PF00892 EamA-like transporter family -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1442 GDP-fucose transporter Cluster-8309.48190 BF_2 74.05 0.52 6228 642929745 XP_008195958.1 2579 3.6e-288 PREDICTED: uncharacterized protein LOC664426 isoform X1 [Tribolium castaneum]>gi|270010581|gb|EFA07029.1| hypothetical protein TcasGA2_TC010001 [Tribolium castaneum] 242020070 XM_002430435.1 44 9.85009e-11 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05433//PF05887//PF06112//PF09172//PF03067 Glycine zipper 2TM domain//Procyclic acidic repetitive protein (PARP)//Gammaherpesvirus capsid protein//Domain of unknown function (DUF1943)//Chitin binding domain GO:0006869 lipid transport GO:0005319 lipid transporter activity GO:0016020//GO:0019867//GO:0019028 membrane//outer membrane//viral capsid -- -- Cluster-8309.48192 BF_2 81.34 0.56 6327 642929749 XP_008195960.1 2122 3.6e-235 PREDICTED: uncharacterized protein LOC664426 isoform X3 [Tribolium castaneum] 242020070 XM_002430435.1 38 2.16524e-07 Pediculus humanus corporis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- PF05433//PF05887//PF03067 Glycine zipper 2TM domain//Procyclic acidic repetitive protein (PARP)//Chitin binding domain -- -- -- -- GO:0019028//GO:0016020//GO:0019867 viral capsid//membrane//outer membrane -- -- Cluster-8309.48196 BF_2 483.94 10.83 2156 642916163 XP_008190912.1 2033 2.5e-225 PREDICTED: abhydrolase domain-containing protein 16A [Tribolium castaneum]>gi|270003703|gb|EFA00151.1| hypothetical protein TcasGA2_TC002972 [Tribolium castaneum] 658893399 XM_008431335.1 63 9.25219e-22 PREDICTED: Poecilia reticulata abhydrolase domain containing 16A (abhd16a), transcript variant X2, mRNA -- -- -- -- Q5R6S0 1171 9.4e-127 Abhydrolase domain-containing protein 16A OS=Pongo abelii GN=ABHD16A PE=2 SV=1 PF00326 Prolyl oligopeptidase family GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- KOG1553 Predicted alpha/beta hydrolase BAT5 Cluster-8309.48197 BF_2 20.00 0.47 2077 91078588 XP_972111.1 2168 5.4e-241 PREDICTED: tyrosine-protein kinase-like otk [Tribolium castaneum] -- -- -- -- -- K05127 PTK7, CCK4 PTK7 protein tyrosine kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K05127 Q13308 739 1.1e-76 Inactive tyrosine-protein kinase 7 OS=Homo sapiens GN=PTK7 PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.48198 BF_2 155.87 1.85 3810 642934333 XP_008198606.1 2979 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X4 [Tribolium castaneum] 817086197 XM_012410395.1 89 5.79494e-36 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF00643//PF14634//PF05929//PF00097//PF05524//PF01436//PF05149//PF01637//PF03358//PF02601//PF01580//PF13639 B-box zinc finger//zinc-RING finger domain//Phage capsid scaffolding protein (GPO) serine peptidase//Zinc finger, C3HC4 type (RING finger)//PEP-utilising enzyme, N-terminal//NHL repeat//Paraflagellar rod protein//Archaeal ATPase//NADPH-dependent FMN reductase//Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain GO:0009401//GO:0006308//GO:0019069 phosphoenolpyruvate-dependent sugar phosphotransferase system//DNA catabolic process//viral capsid assembly GO:0003677//GO:0005524//GO:0005516//GO:0016491//GO:0005515//GO:0008855//GO:0008270//GO:0000166//GO:0046872 DNA binding//ATP binding//calmodulin binding//oxidoreductase activity//protein binding//exodeoxyribonuclease VII activity//zinc ion binding//nucleotide binding//metal ion binding GO:0031514//GO:0005622//GO:0009318 motile cilium//intracellular//exodeoxyribonuclease VII complex -- -- Cluster-8309.48199 BF_2 535.78 78.67 572 546682799 ERL92688.1 323 1.3e-27 hypothetical protein D910_09999 [Dendroctonus ponderosae] -- -- -- -- -- K13189 RBM14 RNA-binding protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13189 Q96PK6 166 8.6e-11 RNA-binding protein 14 OS=Homo sapiens GN=RBM14 PE=1 SV=2 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.4820 BF_2 35.80 0.44 3690 642926421 XP_008191955.1 1584 5.1e-173 PREDICTED: TWiK family of potassium channels protein 7 [Tribolium castaneum]>gi|642926423|ref|XP_008191956.1| PREDICTED: TWiK family of potassium channels protein 7 [Tribolium castaneum]>gi|270008467|gb|EFA04915.1| hypothetical protein TcasGA2_TC014979 [Tribolium castaneum] 195131168 XM_002009987.1 121 9.1267e-54 Drosophila mojavensis GI14916 (Dmoj\GI14916), mRNA -- -- -- -- Q9ES08 170 1.9e-10 Potassium channel subfamily K member 9 OS=Rattus norvegicus GN=Kcnk9 PE=1 SV=2 PF01007//PF17112//PF00520//PF11857//PF12258 Inward rectifier potassium channel//Mitochondrial import receptor subunit Tom6, fungal//Ion transport protein//Domain of unknown function (DUF3377)//Microcephalin protein GO:0006811//GO:0006813//GO:0030150//GO:0021987//GO:0055085 ion transport//potassium ion transport//protein import into mitochondrial matrix//cerebral cortex development//transmembrane transport GO:0005216//GO:0005242//GO:0004222 ion channel activity//inward rectifier potassium channel activity//metalloendopeptidase activity GO:0008076//GO:0005742//GO:0016020//GO:0016021 voltage-gated potassium channel complex//mitochondrial outer membrane translocase complex//membrane//integral component of membrane -- -- Cluster-8309.48200 BF_2 35.95 1.22 1523 642939191 XP_008200374.1 241 1.1e-17 PREDICTED: DNA-binding protein P3A2 isoform X5 [Tribolium castaneum] -- -- -- -- -- K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 154 5.6e-09 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 PF02060 Slow voltage-gated potassium channel GO:0006811//GO:0006813 ion transport//potassium ion transport GO:0005249 voltage-gated potassium channel activity GO:0016020//GO:0008076 membrane//voltage-gated potassium channel complex -- -- Cluster-8309.48201 BF_2 153.00 3.06 2378 642939187 XP_008200372.1 1030 5.7e-109 PREDICTED: DNA-binding protein Ewg isoform X3 [Tribolium castaneum] 462310479 APGK01047307.1 62 3.67598e-21 Dendroctonus ponderosae Seq01047317, whole genome shotgun sequence K11831 NRF1 nuclear respiratory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11831 Q24312 784 7.8e-82 DNA-binding protein Ewg OS=Drosophila melanogaster GN=ewg PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48204 BF_2 235.83 3.87 2835 91087237 XP_975509.1 1259 1.9e-135 PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|642929695|ref|XP_008195939.1| PREDICTED: delta-aminolevulinic acid dehydratase [Tribolium castaneum]>gi|270010578|gb|EFA07026.1| hypothetical protein TcasGA2_TC009997 [Tribolium castaneum] 827564585 CP011663.1 41 2.07159e-09 Clostridium sporogenes strain DSM 795, complete genome K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 1035 7.3e-111 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF03244//PF00490 Photosystem I reaction centre subunit VI//Delta-aminolevulinic acid dehydratase GO:0033014//GO:0015994//GO:0015979 tetrapyrrole biosynthetic process//chlorophyll metabolic process//photosynthesis GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding GO:0009522//GO:0009538 photosystem I//photosystem I reaction center KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.48206 BF_2 263.78 2.37 4943 642939444 XP_008200394.1 1205 6.0e-129 PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939446|ref|XP_008200396.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939448|ref|XP_008200397.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum]>gi|642939450|ref|XP_008200398.1| PREDICTED: transcription factor E2F2-like [Tribolium castaneum] 642939445 XM_008202174.1 38 1.68969e-07 PREDICTED: Tribolium castaneum transcription factor E2F2-like (LOC656396), transcript variant X2, mRNA K06620 E2F3 transcription factor E2F3 http://www.genome.jp/dbget-bin/www_bget?ko:K06620 O00716 437 2.8e-41 Transcription factor E2F3 OS=Homo sapiens GN=E2F3 PE=1 SV=1 PF02319//PF01991 E2F/DP family winged-helix DNA-binding domain//ATP synthase (E/31 kDa) subunit GO:0006355//GO:0015992//GO:0006119//GO:0015991 regulation of transcription, DNA-templated//proton transport//oxidative phosphorylation//ATP hydrolysis coupled proton transport GO:0003700//GO:0046961 transcription factor activity, sequence-specific DNA binding//proton-transporting ATPase activity, rotational mechanism GO:0005667//GO:0033178 transcription factor complex//proton-transporting two-sector ATPase complex, catalytic domain KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.48208 BF_2 256.43 6.67 1895 642917679 XP_008191324.1 527 9.6e-51 PREDICTED: poly(A) polymerase type 3 [Tribolium castaneum]>gi|642917681|ref|XP_008191326.1| PREDICTED: poly(A) polymerase type 3 [Tribolium castaneum] 642917680 XM_008193104.1 52 1.05702e-15 PREDICTED: Tribolium castaneum poly(A) polymerase type 3 (LOC103312455), transcript variant X2, mRNA K14376 PAP poly(A) polymerase http://www.genome.jp/dbget-bin/www_bget?ko:K14376 Q6PCL9 371 4.8e-34 Poly(A) polymerase gamma OS=Mus musculus GN=Papolg PE=1 SV=1 PF04928//PF04926 Poly(A) polymerase central domain//Poly(A) polymerase predicted RNA binding domain GO:0043631 RNA polyadenylation GO:0004652//GO:0003723 polynucleotide adenylyltransferase activity//RNA binding -- -- KOG2245 Poly(A) polymerase and related nucleotidyltransferases Cluster-8309.48209 BF_2 23.62 0.39 2834 524873532 XP_005093511.1 211 6.3e-14 PREDICTED: low-density lipoprotein receptor-related protein 4-like [Aplysia californica] -- -- -- -- -- K03068 LRP5_6 low density lipoprotein receptor-related protein 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K03068 Q9JI18 177 2.3e-11 Low-density lipoprotein receptor-related protein 1B OS=Mus musculus GN=Lrp1b PE=1 SV=1 PF00057//PF14659 Low-density lipoprotein receptor domain class A//Phage integrase, N-terminal SAM-like domain GO:0015074 DNA integration GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.48215 BF_2 70.21 2.93 1288 91092722 XP_972691.1 1473 1.3e-160 PREDICTED: arrestin domain-containing protein 2 isoform X2 [Tribolium castaneum]>gi|270014876|gb|EFA11324.1| hypothetical protein TcasGA2_TC010863 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBH0 266 4.9e-22 Arrestin domain-containing protein 2 OS=Homo sapiens GN=ARRDC2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.48216 BF_2 160.75 1.52 4699 642925990 XP_008194721.1 3152 0.0e+00 PREDICTED: DNA repair and recombination protein RAD54-like [Tribolium castaneum] -- -- -- -- -- K10875 RAD54L, RAD54 DNA repair and recombination protein RAD54 and RAD54-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K10875 Q92698 2269 9.8e-254 DNA repair and recombination protein RAD54-like OS=Homo sapiens GN=RAD54L PE=1 SV=2 PF04851//PF01484//PF00176//PF08658 Type III restriction enzyme, res subunit//Nematode cuticle collagen N-terminal domain//SNF2 family N-terminal domain//Rad54 N terminal -- -- GO:0016817//GO:0042302//GO:0005524//GO:0016787//GO:0003677 hydrolase activity, acting on acid anhydrides//structural constituent of cuticle//ATP binding//hydrolase activity//DNA binding -- -- KOG0390 DNA repair protein, SNF2 family Cluster-8309.48218 BF_2 111.03 2.85 1916 820805520 AKG92751.1 846 9.9e-88 steroid receptor coactivator [Leptinotarsa decemlineata] 820805519 KP147914.1 185 1.24356e-89 Leptinotarsa decemlineata steroid receptor coactivator mRNA, complete cds K11255 NCOA2, TIF2, KAT13C nuclear receptor coactivator 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48221 BF_2 491.09 7.32 3094 270003145 EEZ99592.1 4008 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.3e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF04579//PF00069//PF07714 Keratin, high-sulphur matrix protein//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005198 ATP binding//protein kinase activity//structural molecule activity GO:0045095 keratin filament KOG1094 Discoidin domain receptor DDR1 Cluster-8309.48222 BF_2 1.00 7.23 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48225 BF_2 45.00 0.44 4564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48226 BF_2 139.14 3.44 1977 546675591 ERL86754.1 2118 3.3e-235 hypothetical protein D910_04160 [Dendroctonus ponderosae] 752860506 XM_011253949.1 341 2.44684e-176 PREDICTED: Camponotus floridanus serine/threonine-protein kinase tricorner (LOC105248897), transcript variant X1, mRNA K08790 STK38, NDR serine/threonine kinase 38 http://www.genome.jp/dbget-bin/www_bget?ko:K08790 Q2LZZ7 1949 5.3e-217 Serine/threonine-protein kinase tricorner OS=Drosophila pseudoobscura pseudoobscura GN=trc PE=3 SV=1 PF00069//PF06293//PF00433//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase C terminal domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0605 NDR and related serine/threonine kinases Cluster-8309.48227 BF_2 40.53 0.76 2521 642929027 XP_973541.3 829 1.2e-85 PREDICTED: probable maleylacetoacetate isomerase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01800 maiA, GSTZ1 maleylacetoacetate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01800 Q9VHD2 786 4.9e-82 Probable maleylacetoacetate isomerase 2 OS=Drosophila melanogaster GN=GstZ2 PE=1 SV=1 PF13409//PF02798//PF13417//PF00462 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0005515 protein disulfide oxidoreductase activity//electron carrier activity//protein binding -- -- KOG0868 Glutathione S-transferase Cluster-8309.4823 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48230 BF_2 3.00 0.34 660 642937453 XP_008198842.1 316 9.8e-27 PREDICTED: protein tramtrack, beta isoform-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48231 BF_2 53.38 0.49 4810 91087363 XP_975631.1 632 1.6e-62 PREDICTED: iron-sulfur cluster assembly enzyme ISCU, mitochondrial [Tribolium castaneum]>gi|270010618|gb|EFA07066.1| hypothetical protein TcasGA2_TC010045 [Tribolium castaneum] 844835377 XM_012936598.1 119 1.54249e-52 Schistosoma haematobium Iron-sulfur cluster assembly enzyme ISCU, mitochondrial mRNA K04488 iscU, nifU nitrogen fixation protein NifU and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K04488 Q9D7P6 568 1.8e-56 Iron-sulfur cluster assembly enzyme ISCU, mitochondrial OS=Mus musculus GN=Iscu PE=1 SV=1 PF05735//PF01592//PF09494 Thrombospondin C-terminal region//NifU-like N terminal domain//Slx4 endonuclease GO:0016226//GO:0006281//GO:0007155//GO:0006260//GO:0006308 iron-sulfur cluster assembly//DNA repair//cell adhesion//DNA replication//DNA catabolic process GO:0017108//GO:0005509//GO:0051536//GO:0005506 5'-flap endonuclease activity//calcium ion binding//iron-sulfur cluster binding//iron ion binding GO:0005634//GO:0005576//GO:0033557 nucleus//extracellular region//Slx1-Slx4 complex KOG3361 Iron binding protein involved in Fe-S cluster formation Cluster-8309.48233 BF_2 641.65 14.04 2199 189236353 XP_001807129.1 2395 2.7e-267 PREDICTED: signal recognition particle receptor subunit alpha homolog [Tribolium castaneum]>gi|270005877|gb|EFA02325.1| hypothetical protein TcasGA2_TC007993 [Tribolium castaneum] 720030593 XM_010267260.1 42 4.45448e-10 PREDICTED: Nelumbo nucifera signal recognition particle receptor subunit alpha-like (LOC104603264), transcript variant X4, mRNA K13431 SRPR signal recognition particle receptor subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K13431 Q9U5L1 1446 1.2e-158 Signal recognition particle receptor subunit alpha homolog OS=Drosophila melanogaster GN=Gtp-bp PE=1 SV=2 PF03266//PF01926//PF02881//PF04086//PF00448 NTPase//50S ribosome-binding GTPase//SRP54-type protein, helical bundle domain//Signal recognition particle, alpha subunit, N-terminal//SRP54-type protein, GTPase domain GO:0006614//GO:0006886//GO:0006184 SRP-dependent cotranslational protein targeting to membrane//intracellular protein transport//obsolete GTP catabolic process GO:0098519//GO:0003924//GO:0005525//GO:0005047 nucleotide phosphatase activity, acting on free nucleotides//GTPase activity//GTP binding//signal recognition particle binding GO:0005786//GO:0005785 signal recognition particle, endoplasmic reticulum targeting//signal recognition particle receptor complex KOG0781 Signal recognition particle receptor, alpha subunit Cluster-8309.48234 BF_2 652.00 8.85 3369 91082299 XP_974015.1 1414 2.4e-153 PREDICTED: cell differentiation protein RCD1 homolog [Tribolium castaneum]>gi|270007201|gb|EFA03649.1| hypothetical protein TcasGA2_TC013743 [Tribolium castaneum] -- -- -- -- -- K12606 RCD1, CNOT9, CAF40 CCR4-NOT transcription complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K12606 A7MB47 1248 1.7e-135 Cell differentiation protein RCD1 homolog OS=Bos taurus GN=RQCD1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3036 Protein involved in cell differentiation/sexual development Cluster-8309.48235 BF_2 16.00 0.69 1259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48236 BF_2 286.91 4.58 2910 642922915 XP_008200450.1 3722 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 361 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2244 4.8e-251 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF00071//PF02421//PF01926//PF13304//PF01031//PF08477 Ras family//Ferrous iron transport protein B//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Dynamin central region//Ras of Complex, Roc, domain of DAPkinase GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0005524//GO:0015093//GO:0003924 GTP binding//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.48237 BF_2 53.69 1.20 2152 91079304 XP_966317.1 1435 5.6e-156 PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|91079306|ref|XP_975771.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum]>gi|642917073|ref|XP_008191109.1| PREDICTED: protein N-terminal asparagine amidohydrolase [Tribolium castaneum] -- -- -- -- -- K14662 NTAN1 protein N-terminal asparagine amidohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K14662 Q96AB6 648 4.2e-66 Protein N-terminal asparagine amidohydrolase OS=Homo sapiens GN=NTAN1 PE=1 SV=3 PF14736 Protein N-terminal asparagine amidohydrolase GO:0006528 asparagine metabolic process GO:0008418 protein-N-terminal asparagine amidohydrolase activity -- -- -- -- Cluster-8309.48238 BF_2 72.56 1.10 3038 91081979 XP_968359.1 2904 0.0e+00 PREDICTED: ubiquitin-protein ligase E3C [Tribolium castaneum]>gi|270007369|gb|EFA03817.1| hypothetical protein TcasGA2_TC013932 [Tribolium castaneum] -- -- -- -- -- K10589 UBE3C ubiquitin-protein ligase E3 C http://www.genome.jp/dbget-bin/www_bget?ko:K10589 Q15386 1282 1.8e-139 Ubiquitin-protein ligase E3C OS=Homo sapiens GN=UBE3C PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.48241 BF_2 98.30 1.02 4305 270008878 EFA05326.1 1127 5.8e-120 hypothetical protein TcasGA2_TC015490 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O62589 347 6.7e-31 Serine protease gd OS=Drosophila melanogaster GN=gd PE=1 SV=2 PF15957//PF03067//PF04277//PF00089 Commissureless//Chitin binding domain//Oxaloacetate decarboxylase, gamma chain//Trypsin GO:0006560//GO:0006525//GO:0007411//GO:0006814//GO:0006090//GO:0071436//GO:0006508 proline metabolic process//arginine metabolic process//axon guidance//sodium ion transport//pyruvate metabolic process//sodium ion export//proteolysis GO:0008948//GO:0015081//GO:0004252 oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity//serine-type endopeptidase activity GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.48243 BF_2 250.25 2.66 4230 642938247 XP_008198128.1 296 1.3e-23 PREDICTED: serine/threonine-protein kinase Doa isoform X3 [Tribolium castaneum] 642938246 XM_008199906.1 58 1.10073e-18 PREDICTED: Tribolium castaneum serine/threonine-protein kinase Doa (LOC659421), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF17096//PF02932//PF01080//PF03293 Altered inheritance of mitochondria protein 3//Neurotransmitter-gated ion-channel transmembrane region//Presenilin//Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006144//GO:0006351//GO:0019083//GO:0006811//GO:0051016//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//viral transcription//ion transport//barbed-end actin filament capping//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0004190 DNA-directed RNA polymerase activity//DNA binding//aspartic-type endopeptidase activity GO:0016021//GO:0030479//GO:0005730//GO:0016020 integral component of membrane//actin cortical patch//nucleolus//membrane -- -- Cluster-8309.48245 BF_2 15.00 0.48 1603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48246 BF_2 23.08 1.19 1102 91088815 XP_976275.1 426 2.9e-39 PREDICTED: uncharacterized protein LOC658222 [Tribolium castaneum]>gi|270011614|gb|EFA08062.1| hypothetical protein TcasGA2_TC005658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48247 BF_2 16.92 0.32 2481 478250027 ENN70533.1 303 1.2e-24 hypothetical protein YQE_12709, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48248 BF_2 5.35 0.50 732 91088815 XP_976275.1 492 4.2e-47 PREDICTED: uncharacterized protein LOC658222 [Tribolium castaneum]>gi|270011614|gb|EFA08062.1| hypothetical protein TcasGA2_TC005658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48249 BF_2 10.65 0.53 1128 91088815 XP_976275.1 492 6.5e-47 PREDICTED: uncharacterized protein LOC658222 [Tribolium castaneum]>gi|270011614|gb|EFA08062.1| hypothetical protein TcasGA2_TC005658 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48250 BF_2 370.86 2.19 7376 270009468 EFA05916.1 1259 4.9e-135 hypothetical protein TcasGA2_TC008732 [Tribolium castaneum] 686207191 AP014521.1 40 1.95298e-08 Candidatus Tachikawaea gelatinosa DNA, complete genome K15791 DHKTD1 probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15791 Q6P286 968 1.1e-102 Probable 2-oxoglutarate dehydrogenase E1 component DHKTD1, mitochondrial OS=Xenopus laevis GN=dhtkd1 PE=2 SV=1 PF00676//PF09412 Dehydrogenase E1 component//Endoribonuclease XendoU GO:0008152 metabolic process GO:0016788//GO:0016624 hydrolase activity, acting on ester bonds//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor -- -- KOG0450 2-oxoglutarate dehydrogenase, E1 subunit Cluster-8309.48257 BF_2 638.61 2.44 11257 642936312 XP_008198391.1 8183 0.0e+00 PREDICTED: dedicator of cytokinesis protein 3 [Tribolium castaneum] 751206253 XM_011157338.1 165 9.72605e-78 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 3630 0.0e+00 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 PF14604//PF00018//PF01608//PF07651//PF03822 Variant SH3 domain//SH3 domain//I/LWEQ domain//ANTH domain//NAF domain GO:0007165 signal transduction GO:0005543//GO:0003779//GO:0005515 phospholipid binding//actin binding//protein binding -- -- KOG1998 Signaling protein DOCK180 Cluster-8309.48260 BF_2 438.78 11.91 1828 642917631 XP_008193400.1 1859 3.2e-205 PREDICTED: cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K14589 CMTR1, FTSJD2, MTR1 cap1 methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14589 Q803R5 967 3.6e-103 Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 OS=Danio rerio GN=cmtr1 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG3673 FtsJ-like RNA methyltransferase Cluster-8309.48262 BF_2 5.00 5.23 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48266 BF_2 730.57 13.78 2505 332374040 AEE62161.1 1406 1.5e-152 unknown [Dendroctonus ponderosae]>gi|478259932|gb|ENN79734.1| hypothetical protein YQE_03790, partial [Dendroctonus ponderosae]>gi|546674727|gb|ERL86036.1| hypothetical protein D910_03450 [Dendroctonus ponderosae] -- -- -- -- -- K00965 galT, GALT UDPglucose--hexose-1-phosphate uridylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00965 Q9VMA2 1039 2.2e-111 Probable galactose-1-phosphate uridylyltransferase OS=Drosophila melanogaster GN=Galt PE=2 SV=2 PF02744//PF07074//PF01087 Galactose-1-phosphate uridyl transferase, C-terminal domain//Translocon-associated protein, gamma subunit (TRAP-gamma)//Galactose-1-phosphate uridyl transferase, N-terminal domain GO:0006012//GO:0006613//GO:0009117 galactose metabolic process//cotranslational protein targeting to membrane//nucleotide metabolic process GO:0008108 UDP-glucose:hexose-1-phosphate uridylyltransferase activity GO:0030176//GO:0005784 integral component of endoplasmic reticulum membrane//Sec61 translocon complex KOG2958 Galactose-1-phosphate uridylyltransferase Cluster-8309.48267 BF_2 50.47 0.80 2910 642913836 XP_001815393.2 1504 7.5e-164 PREDICTED: engulfment and cell motility protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92556 408 3.8e-38 Engulfment and cell motility protein 1 OS=Homo sapiens GN=ELMO1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48268 BF_2 1255.85 11.77 4752 270014286 EFA10734.1 1118 7.1e-119 transformer2, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O18391 492 1.1e-47 Probable serine hydrolase OS=Drosophila melanogaster GN=kraken PE=2 SV=1 PF07819//PF02205 PGAP1-like protein//WH2 motif GO:0006886//GO:0006505 intracellular protein transport//GPI anchor metabolic process GO:0003779//GO:0016788 actin binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.48273 BF_2 127.88 2.70 2265 189241329 XP_001808868.1 187 3.0e-11 PREDICTED: uncharacterized protein LOC100142578 [Tribolium castaneum]>gi|270014077|gb|EFA10525.1| hypothetical protein TcasGA2_TC012777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005750//GO:0005743 mitochondrial respiratory chain complex III//mitochondrial inner membrane -- -- Cluster-8309.48277 BF_2 402.42 2.04 8525 189234241 XP_976116.2 354 5.0e-30 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 194896366 XM_001978429.1 74 2.84034e-27 Drosophila erecta GG19602 (Dere\GG19602), mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 262 9.5e-21 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF06305//PF04145//PF02033 Protein of unknown function (DUF1049)//Ctr copper transporter family//Ribosome-binding factor A GO:0006825//GO:0035434//GO:0006364 copper ion transport//copper ion transmembrane transport//rRNA processing GO:0005375 copper ion transmembrane transporter activity GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG3386 Copper transporter Cluster-8309.48278 BF_2 58.00 1.56 1838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48279 BF_2 236.63 1.20 8519 478261817 ENN80940.1 1262 2.5e-135 hypothetical protein YQE_02645, partial [Dendroctonus ponderosae]>gi|546673708|gb|ERL85267.1| hypothetical protein D910_02688 [Dendroctonus ponderosae] -- -- -- -- -- K05610 UCHL5, UCH37 ubiquitin carboxyl-terminal hydrolase L5 http://www.genome.jp/dbget-bin/www_bget?ko:K05610 Q9XSJ0 1055 1.1e-112 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos taurus GN=UCHL5 PE=2 SV=1 PF00397//PF01404//PF00552//PF02845//PF01088//PF00325 WW domain//Ephrin receptor ligand binding domain//Integrase DNA binding domain//CUE domain//Ubiquitin carboxyl-terminal hydrolase, family 1//Bacterial regulatory proteins, crp family GO:0016579//GO:0006355//GO:0006511//GO:0006508//GO:0048013 protein deubiquitination//regulation of transcription, DNA-templated//ubiquitin-dependent protein catabolic process//proteolysis//ephrin receptor signaling pathway GO:0005515//GO:0004843//GO:0003677//GO:0003676 protein binding//ubiquitin-specific protease activity//DNA binding//nucleic acid binding GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.4828 BF_2 10.00 0.34 1524 359843230 AEV89750.1 610 1.8e-60 superoxide dismutase [Schistocerca gregaria] -- -- -- -- -- K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 Q8HXQ1 533 6.4e-53 Superoxide dismutase [Cu-Zn] OS=Macaca fascicularis GN=SOD1 PE=2 SV=3 PF00080//PF13241 Copper/zinc superoxide dismutase (SODC)//Putative NAD(P)-binding GO:0006779//GO:0055114//GO:0006801//GO:0019354 porphyrin-containing compound biosynthetic process//oxidation-reduction process//superoxide metabolic process//siroheme biosynthetic process GO:0046872//GO:0043115 metal ion binding//precorrin-2 dehydrogenase activity -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8309.48280 BF_2 42.53 0.48 4022 642927313 XP_974796.3 1396 3.5e-151 PREDICTED: uncharacterized protein LOC663667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.9e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF08043//PF03359//PF01544//PF02653 Xin repeat//Guanylate-kinase-associated protein (GKAP) protein//CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component GO:0006810//GO:0055085//GO:0030001//GO:0030036//GO:0023052 transport//transmembrane transport//metal ion transport//actin cytoskeleton organization//signaling GO:0003779//GO:0005215//GO:0046873 actin binding//transporter activity//metal ion transmembrane transporter activity GO:0016020//GO:0030054 membrane//cell junction KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.48281 BF_2 53.05 0.40 5801 642914389 XP_008201657.1 2571 2.8e-287 PREDICTED: STE20-like serine/threonine-protein kinase [Tribolium castaneum] -- -- -- -- -- K08836 SLK STE20-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08836 Q9H2G2 693 6.8e-71 STE20-like serine/threonine-protein kinase OS=Homo sapiens GN=SLK PE=1 SV=1 PF12474//PF06293//PF00069//PF07714 Polo kinase kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004674//GO:0004672//GO:0016773 ATP binding//protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.48283 BF_2 413.74 3.18 5723 642931136 XP_967600.2 3863 0.0e+00 PREDICTED: DNA-directed RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270012086|gb|EFA08534.1| hypothetical protein TcasGA2_TC006188 [Tribolium castaneum] -- -- -- -- -- K10908 POLRMT, RPO41 DNA-directed RNA polymerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K10908 Q8BKF1 1977 8.7e-220 DNA-directed RNA polymerase, mitochondrial OS=Mus musculus GN=Polrmt PE=2 SV=1 PF00940//PF03840 DNA-dependent RNA polymerase//Preprotein translocase SecG subunit GO:0009306//GO:0006144//GO:0006351//GO:0015031//GO:0006206 protein secretion//purine nucleobase metabolic process//transcription, DNA-templated//protein transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0016740//GO:0003677//GO:0015450 DNA-directed RNA polymerase activity//transferase activity//DNA binding//P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0016021//GO:0009941//GO:0005730 integral component of membrane//chloroplast envelope//nucleolus KOG1038 Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation Cluster-8309.48284 BF_2 147.85 1.31 5007 91084547 XP_973113.1 3577 0.0e+00 PREDICTED: protein unc-45 homolog B [Tribolium castaneum]>gi|270009248|gb|EFA05696.1| translocase of outer membrane 34 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68F64 1674 1.0e-184 Protein unc-45 homolog B OS=Xenopus laevis GN=unc45b PE=2 SV=1 PF00839//PF00514//PF13181//PF13176//PF03152//PF08718//PF13414//PF13371//PF13374//PF00515 Cysteine rich repeat//Armadillo/beta-catenin-like repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Ubiquitin fusion degradation protein UFD1//Glycolipid transfer protein (GLTP)//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0046836//GO:0006511 glycolipid transport//ubiquitin-dependent protein catabolic process GO:0005515//GO:0017089//GO:0051861 protein binding//glycolipid transporter activity//glycolipid binding GO:0005737//GO:0016020 cytoplasm//membrane KOG1816 Ubiquitin fusion-degradation protein Cluster-8309.48286 BF_2 126.82 0.95 5889 642925611 XP_008194640.1 2652 1.2e-296 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 2.6e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48288 BF_2 9.48 0.41 1253 546681613 ERL91677.1 888 8.7e-93 hypothetical protein D910_09004 [Dendroctonus ponderosae] 573874497 XM_006625570.1 43 6.97092e-11 PREDICTED: Lepisosteus oculatus 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-like (LOC102694917), mRNA K01103 PFKFB3 6-phosphofructo-2-kinase / fructose-2,6-biphosphatase 3  http://www.genome.jp/dbget-bin/www_bget?ko:K01103 Q5NVT1 404 4.8e-38 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 OS=Pongo abelii GN=PFKFB2 PE=2 SV=1 PF06414//PF01591 Zeta toxin//6-phosphofructo-2-kinase GO:0006000//GO:0006013 fructose metabolic process//mannose metabolic process GO:0016301//GO:0005524//GO:0003873 kinase activity//ATP binding//6-phosphofructo-2-kinase activity -- -- KOG0234 Fructose-6-phosphate 2-kinase/fructose-2,6-biphosphatase Cluster-8309.48289 BF_2 2938.66 39.98 3362 642922441 XP_008193170.1 2357 1.1e-262 PREDICTED: glucose-6-phosphate dehydrogenase isoform X1 [Tribolium castaneum]>gi|270007117|gb|EFA03565.1| hypothetical protein TcasGA2_TC013648 [Tribolium castaneum] 642922838 XM_968977.2 327 2.53921e-168 PREDICTED: Tribolium castaneum isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial-like (LOC662903), transcript variant X2, mRNA K00036 G6PD, zwf glucose-6-phosphate 1-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00036 P12646 1929 1.9e-214 Glucose-6-phosphate 1-dehydrogenase OS=Drosophila melanogaster GN=Zw PE=1 SV=2 PF02781//PF00180//PF00479 Glucose-6-phosphate dehydrogenase, C-terminal domain//Isocitrate/isopropylmalate dehydrogenase//Glucose-6-phosphate dehydrogenase, NAD binding domain GO:0055114//GO:0006098//GO:0006006//GO:0006749 oxidation-reduction process//pentose-phosphate shunt//glucose metabolic process//glutathione metabolic process GO:0016616//GO:0004345//GO:0050661 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//glucose-6-phosphate dehydrogenase activity//NADP binding -- -- KOG0563 Glucose-6-phosphate 1-dehydrogenase Cluster-8309.48294 BF_2 148.86 1.76 3832 642912272 XP_008200632.1 786 1.8e-80 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 259 9.5e-21 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF01414//PF00089 Delta serrate ligand//Trypsin GO:0006508//GO:0007154 proteolysis//cell communication GO:0004252 serine-type endopeptidase activity GO:0016020 membrane -- -- Cluster-8309.48296 BF_2 1.00 0.88 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48298 BF_2 155.02 1.45 4771 270013807 EFA10255.1 2967 0.0e+00 hypothetical protein TcasGA2_TC012455 [Tribolium castaneum] -- -- -- -- -- K04648 DCTN1 dynactin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04648 P13496 1855 1.0e-205 Dynactin subunit 1 OS=Drosophila melanogaster GN=Gl PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0971 Microtubule-associated protein dynactin DCTN1/Glued Cluster-8309.48299 BF_2 87.59 5.95 903 642926336 XP_008194882.1 653 1.1e-65 PREDICTED: LOW QUALITY PROTEIN: retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta [Tribolium castaneum] 642926335 XM_008196660.1 192 7.38168e-94 PREDICTED: Tribolium castaneum retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (LOC657343), mRNA K13758 PDE6D retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K13758 Q9XT54 580 1.3e-58 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta OS=Canis familiaris GN=PDE6D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4038 cGMP-phosphodiesterase, delta subunit Cluster-8309.483 BF_2 11.85 0.76 939 769864913 XP_011644363.1 276 6.0e-22 PREDICTED: GSK3-beta interaction protein [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- Q7ZWI4 197 3.6e-14 GSK3-beta interaction protein OS=Danio rerio GN=gskip PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3965 Uncharacterized conserved protein Cluster-8309.48304 BF_2 9.98 0.61 972 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48307 BF_2 5.00 1.59 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48310 BF_2 28.00 3.52 620 3287775 P81387.1 400 1.7e-36 RecName: Full=Cuticle protein AMP3; AltName: Full=HA-AMP3 [Homarus americanus] -- -- -- -- -- -- -- -- -- P81576 446 3.2e-43 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.48313 BF_2 321.73 7.30 2131 642910461 XP_008190748.1 2013 5.3e-223 PREDICTED: fibroblast growth factor receptor homolog 1-like isoform X2 [Tribolium castaneum] 462340826 APGK01036266.1 75 1.95134e-28 Dendroctonus ponderosae Seq01036276, whole genome shotgun sequence K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 Q07407 1199 5.3e-130 Fibroblast growth factor receptor homolog 1 OS=Drosophila melanogaster GN=htl PE=1 SV=3 PF02313//PF00069//PF07714//PF06305 Fumarate reductase subunit D//Protein kinase domain//Protein tyrosine kinase//Protein of unknown function (DUF1049) GO:0006468//GO:0006106 protein phosphorylation//fumarate metabolic process GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005887//GO:0016020 integral component of plasma membrane//membrane -- -- Cluster-8309.48314 BF_2 360.73 1.87 8358 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.68771e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF10233//PF01059//PF16692//PF09606//PF00400//PF00472 Uncharacterized conserved protein CG6151-P//NADH-ubiquinone oxidoreductase chain 4, amino terminus//Folliculin C-terminal domain//ARC105 or Med15 subunit of Mediator complex non-fungal//WD domain, G-beta repeat//RF-1 domain GO:0006120//GO:0006449//GO:0055114//GO:0043087//GO:0006415//GO:0006357 mitochondrial electron transport, NADH to ubiquinone//regulation of translational termination//oxidation-reduction process//regulation of GTPase activity//translational termination//regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0003747//GO:0001104//GO:0005085 protein binding//translation release factor activity//RNA polymerase II transcription cofactor activity//guanyl-nucleotide exchange factor activity GO:0016021//GO:0016592//GO:0018444//GO:0005840 integral component of membrane//mediator complex//translation release factor complex//ribosome KOG3154 Uncharacterized conserved protein Cluster-8309.48318 BF_2 73.41 0.38 8296 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.67513e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF01059//PF00400//PF00472//PF16692 NADH-ubiquinone oxidoreductase chain 4, amino terminus//WD domain, G-beta repeat//RF-1 domain//Folliculin C-terminal domain GO:0055114//GO:0043087//GO:0006415//GO:0006120//GO:0006449 oxidation-reduction process//regulation of GTPase activity//translational termination//mitochondrial electron transport, NADH to ubiquinone//regulation of translational termination GO:0005515//GO:0003747//GO:0005085 protein binding//translation release factor activity//guanyl-nucleotide exchange factor activity GO:0018444//GO:0005840 translation release factor complex//ribosome KOG3154 Uncharacterized conserved protein Cluster-8309.48320 BF_2 41.74 1.07 1912 646712642 KDR17338.1 453 3.7e-42 Protein takeout [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9VBV3 219 2.1e-16 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 PF06978 Ribonucleases P/MRP protein subunit POP1 GO:0001682//GO:0051252//GO:0008033 tRNA 5'-leader removal//regulation of RNA metabolic process//tRNA processing GO:0004526 ribonuclease P activity GO:0030677 ribonuclease P complex -- -- Cluster-8309.48323 BF_2 715.86 4.05 7675 642917299 XP_008199241.1 7102 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X2 [Tribolium castaneum] 665815961 XM_008558446.1 862 0 PREDICTED: Microplitis demolitor disco-interacting protein 2 homolog A (LOC103577686), transcript variant X5, mRNA -- -- -- -- Q9W0S9 5103 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF01297//PF00501//PF06464 Zinc-uptake complex component A periplasmic//AMP-binding enzyme//DMAP1-binding Domain GO:0030001//GO:0008152 metal ion transport//metabolic process GO:0008134//GO:0046872//GO:0003824 transcription factor binding//metal ion binding//catalytic activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3628 Predicted AMP-binding protein Cluster-8309.48326 BF_2 59.51 0.80 3390 91081173 XP_975583.1 1068 3.2e-113 PREDICTED: mitochondrial 2-oxodicarboxylate carrier [Tribolium castaneum]>gi|270006043|gb|EFA02491.1| hypothetical protein TcasGA2_TC008186 [Tribolium castaneum] -- -- -- -- -- K15110 SLC25A21, ODC solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15110 Q9BQT8 761 5.2e-79 Mitochondrial 2-oxodicarboxylate carrier OS=Homo sapiens GN=SLC25A21 PE=1 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0754 Mitochondrial oxodicarboxylate carrier protein Cluster-8309.4833 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48332 BF_2 1086.47 7.18 6616 642927984 XP_008195472.1 731 7.4e-74 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08299//PF05028 Bacterial dnaA protein helix-turn-helix//Poly (ADP-ribose) glycohydrolase (PARG) GO:0006275//GO:0006270//GO:0005975 regulation of DNA replication//DNA replication initiation//carbohydrate metabolic process GO:0005524//GO:0043565//GO:0004649 ATP binding//sequence-specific DNA binding//poly(ADP-ribose) glycohydrolase activity -- -- -- -- Cluster-8309.48334 BF_2 924.00 15.67 2754 642924477 XP_008194313.1 1368 4.2e-148 PREDICTED: insulin-like growth factor-binding protein complex acid labile subunit [Tribolium castaneum]>gi|270007914|gb|EFA04362.1| hypothetical protein TcasGA2_TC014658 [Tribolium castaneum] 642924476 XM_008196091.1 186 4.99452e-90 PREDICTED: Tribolium castaneum insulin-like growth factor-binding protein complex acid labile subunit (LOC660991), mRNA -- -- -- -- O94898 299 1.6e-25 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Homo sapiens GN=LRIG2 PE=2 SV=3 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48337 BF_2 191.57 4.35 2128 91092598 XP_970550.1 686 3.9e-69 PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|642921812|ref|XP_008199330.1| PREDICTED: dual specificity protein phosphatase 21 [Tribolium castaneum]>gi|270006629|gb|EFA03077.1| hypothetical protein TcasGA2_TC010951 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q8NEJ0 361 7.8e-33 Dual specificity protein phosphatase 18 OS=Homo sapiens GN=DUSP18 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0016311//GO:0006570//GO:0006470 dephosphorylation//tyrosine metabolic process//protein dephosphorylation GO:0008138//GO:0016791//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//phosphatase activity//protein tyrosine phosphatase activity -- -- KOG1718 Dual specificity phosphatase Cluster-8309.48339 BF_2 2.00 1.29 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48340 BF_2 135.59 3.97 1717 642936844 XP_008197869.1 1620 1.6e-177 PREDICTED: E3 ubiquitin-protein ligase listerin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VW09 741 5.5e-77 E3 ubiquitin-protein ligase listerin OS=Drosophila melanogaster GN=l(3)76BDr PE=1 SV=2 PF12861//PF13639//PF00097//PF16866//PF12678//PF12906//PF00628//PF00130 Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Zinc finger, C3HC4 type (RING finger)//PHD-finger//RING-H2 zinc finger//RING-variant domain//PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0016567 intracellular signal transduction//protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0803 Predicted E3 ubiquitin ligase Cluster-8309.48341 BF_2 2.00 0.88 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48343 BF_2 15.00 0.60 1340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48346 BF_2 344.71 3.42 4499 642931932 XP_973544.3 3188 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 6 [Tribolium castaneum]>gi|270012741|gb|EFA09189.1| structural maintenance of chromosomes 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9I7 1238 3.4e-134 Structural maintenance of chromosomes protein 6 OS=Xenopus laevis GN=smc6 PE=2 SV=1 PF01580//PF05557//PF00038//PF10473//PF16716//PF04108//PF13304//PF04632//PF04336 FtsK/SpoIIIE family//Mitotic checkpoint protein//Intermediate filament protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Bone marrow stromal antigen 2//Autophagy protein Apg17//AAA domain, putative AbiEii toxin, Type IV TA system//Fusaric acid resistance protein family//Protein of unknown function, DUF479 GO:0015940//GO:0006914//GO:0006810//GO:0007094//GO:0006633//GO:0051607 pantothenate biosynthetic process//autophagy//transport//mitotic spindle assembly checkpoint//fatty acid biosynthetic process//defense response to virus GO:0000166//GO:0005524//GO:0008770//GO:0005198//GO:0045502//GO:0008134//GO:0042803//GO:0003677 nucleotide binding//ATP binding//[acyl-carrier-protein] phosphodiesterase activity//structural molecule activity//dynein binding//transcription factor binding//protein homodimerization activity//DNA binding GO:0005882//GO:0030286//GO:0005886//GO:0005667 intermediate filament//dynein complex//plasma membrane//transcription factor complex KOG0250 DNA repair protein RAD18 (SMC family protein) Cluster-8309.48347 BF_2 201.66 4.83 2032 91094503 XP_971555.1 1652 3.6e-181 PREDICTED: tyrosine-protein kinase Fps85D isoform X2 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1070 4.6e-115 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF08702 Fibrinogen alpha/beta chain family GO:0051258//GO:0030168//GO:0007165 protein polymerization//platelet activation//signal transduction GO:0005102//GO:0030674 receptor binding//protein binding, bridging GO:0005577 fibrinogen complex -- -- Cluster-8309.48348 BF_2 14.03 0.44 1629 478251183 ENN71659.1 940 1.1e-98 hypothetical protein YQE_11757, partial [Dendroctonus ponderosae] -- -- -- -- -- K01920 gshB, GSS glutathione synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01920 Q9NWS8 525 5.8e-52 Required for meiotic nuclear division protein 1 homolog OS=Homo sapiens GN=RMND1 PE=1 SV=2 PF00540 gag gene protein p17 (matrix protein) -- -- GO:0005198 structural molecule activity -- -- KOG2861 Uncharacterized conserved protein Cluster-8309.48349 BF_2 191.97 6.22 1579 478251183 ENN71659.1 1253 5.2e-135 hypothetical protein YQE_11757, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NWS8 603 5.1e-61 Required for meiotic nuclear division protein 1 homolog OS=Homo sapiens GN=RMND1 PE=1 SV=2 PF00540 gag gene protein p17 (matrix protein) -- -- GO:0005198 structural molecule activity -- -- KOG2861 Uncharacterized conserved protein Cluster-8309.48357 BF_2 10.00 1.73 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48359 BF_2 1524.33 15.90 4297 478259502 ENN79383.1 4928 0.0e+00 hypothetical protein YQE_04170, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- H9JIQ1 3852 0.0e+00 Protein mesh OS=Bombyx mori PE=1 SV=1 PF06119//PF05434//PF00779//PF04277//PF02487//PF01833 Nidogen-like//TMEM9//BTK motif//Oxaloacetate decarboxylase, gamma chain//CLN3 protein//IPT/TIG domain GO:0035556//GO:0006814//GO:0006090//GO:0007160//GO:0071436//GO:0006560//GO:0006525 intracellular signal transduction//sodium ion transport//pyruvate metabolic process//cell-matrix adhesion//sodium ion export//proline metabolic process//arginine metabolic process GO:0015081//GO:0008948//GO:0005515 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity//protein binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG4291 Mucin/alpha-tectorin Cluster-8309.48360 BF_2 32.30 0.89 1799 16903179 AAK61417.1 297 4.3e-24 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48364 BF_2 29.77 1.08 1443 478250113 ENN70619.1 462 2.5e-43 hypothetical protein YQE_12793, partial [Dendroctonus ponderosae] -- -- -- -- -- K15104 SLC25A11, OGC solute carrier family 25 (mitochondrial oxoglutarate transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K15104 P22292 396 4.6e-37 Mitochondrial 2-oxoglutarate/malate carrier protein OS=Bos taurus GN=SLC25A11 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0759 Mitochondrial oxoglutarate/malate carrier proteins Cluster-8309.48366 BF_2 67.04 1.37 2341 478258657 ENN78707.1 891 7.3e-93 hypothetical protein YQE_04879, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48368 BF_2 262.83 1.86 6213 91077030 XP_967400.1 1924 3.2e-212 PREDICTED: poly(ADP-ribose) glycohydrolase [Tribolium castaneum]>gi|270002018|gb|EEZ98465.1| hypothetical protein TcasGA2_TC000956 [Tribolium castaneum] -- -- -- -- -- K07759 PARG poly(ADP-ribose) glycohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K07759 O46043 1115 8.5e-120 Poly(ADP-ribose) glycohydrolase OS=Drosophila melanogaster GN=Parg PE=1 SV=3 PF00069//PF06293//PF03604//PF05028//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//DNA directed RNA polymerase, 7 kDa subunit//Poly (ADP-ribose) glycohydrolase (PARG)//Protein tyrosine kinase GO:0006206//GO:0005975//GO:0006351//GO:0006144//GO:0006468 pyrimidine nucleobase metabolic process//carbohydrate metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//protein phosphorylation GO:0016773//GO:0004649//GO:0004672//GO:0005524//GO:0003899//GO:0003677 phosphotransferase activity, alcohol group as acceptor//poly(ADP-ribose) glycohydrolase activity//protein kinase activity//ATP binding//DNA-directed RNA polymerase activity//DNA binding GO:0016020//GO:0005730 membrane//nucleolus KOG3087 Serine/threonine protein kinase Cluster-8309.48371 BF_2 28.65 0.76 1861 270003747 EFA00195.1 2141 6.6e-238 hypothetical protein TcasGA2_TC003020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P53619 1440 5.2e-158 Coatomer subunit delta OS=Bos taurus GN=ARCN1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2635 Medium subunit of clathrin adaptor complex Cluster-8309.48374 BF_2 186.47 3.31 2643 642921021 XP_974765.2 814 7.0e-84 PREDICTED: uncharacterized protein LOC663634 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48375 BF_2 301.90 4.93 2848 642921021 XP_974765.2 814 7.6e-84 PREDICTED: uncharacterized protein LOC663634 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48378 BF_2 69.00 2.40 1492 546673846 ERL85378.1 430 1.3e-39 hypothetical protein D910_02798 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48387 BF_2 101.00 2.25 2165 -- -- -- -- -- 642913530 XM_966293.2 135 8.78019e-62 PREDICTED: Tribolium castaneum methyl-CpG-binding domain protein 5 (LOC660029), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48388 BF_2 11.00 0.39 1471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48391 BF_2 548.06 2.84 8351 86515334 NP_001034492.1 4335 0.0e+00 chitin synthase 2 [Tribolium castaneum]>gi|33867321|gb|AAQ55061.1| chitin synthase CHS2 [Tribolium castaneum]>gi|34148365|gb|AAQ62692.1| chitin synthase [Tribolium castaneum]>gi|270014271|gb|EFA10719.1| chitin synthase 2 [Tribolium castaneum] -- -- -- -- -- K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q9H3F6 946 4.5e-100 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens GN=KCTD10 PE=1 SV=1 PF02186//PF00651//PF03233//PF02214 TFIIE beta subunit core domain//BTB/POZ domain//Aphid transmission protein//BTB/POZ domain GO:0051260//GO:0006367//GO:0019089 protein homooligomerization//transcription initiation from RNA polymerase II promoter//transmission of virus GO:0005515//GO:0016757 protein binding//transferase activity, transferring glycosyl groups -- -- KOG2716 Polymerase delta-interacting protein PDIP1 and related proteins, contain BTB/POZ domain Cluster-8309.48392 BF_2 55.00 10.32 510 546685505 ERL95003.1 230 7.0e-17 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06455 NADH dehydrogenase subunit 5 C-terminus GO:0006814//GO:0042773//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ATP synthesis coupled electron transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-8309.48393 BF_2 290.40 3.11 4189 546683303 ERL93135.1 484 2.1e-45 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- K01345 CELA3 pancreatic endopeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01345 P13582 299 2.4e-25 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF06305//PF00089 Protein of unknown function (DUF1049)//Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0005887 integral component of plasma membrane -- -- Cluster-8309.48394 BF_2 204.60 3.25 2921 91084489 XP_971806.1 713 4.0e-72 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103 CD20-like family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48395 BF_2 877.64 5.85 6564 332373456 AEE61869.1 1731 8.1e-190 unknown [Dendroctonus ponderosae]>gi|478257157|gb|ENN77320.1| hypothetical protein YQE_06146, partial [Dendroctonus ponderosae] 701345709 XM_009975740.1 83 2.16873e-32 PREDICTED: Tyto alba UDP-glucuronic acid decarboxylase 1 (LOC104368417), partial mRNA K08678 UXS1, uxs UDP-glucuronate decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K08678 Q6DF08 1329 1.4e-144 UDP-glucuronic acid decarboxylase 1 OS=Xenopus tropicalis GN=uxs1 PE=2 SV=1 PF01073//PF00293//PF00106//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NUDIX domain//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003854//GO:0050662//GO:0003824//GO:0016787 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//hydrolase activity -- -- KOG1429 dTDP-glucose 4-6-dehydratase/UDP-glucuronic acid decarboxylase Cluster-8309.48396 BF_2 112.41 1.12 4476 642922521 XP_008193210.1 2779 0.0e+00 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q26626 1116 4.7e-120 Kinesin-associated protein 3 OS=Strongylocentrotus purpuratus GN=KAP115 PE=1 SV=1 PF02985//PF00514 HEAT repeat//Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.48398 BF_2 406.37 2.39 7414 642939438 XP_008200391.1 4034 0.0e+00 PREDICTED: maternal protein pumilio isoform X4 [Tribolium castaneum] 642939437 XM_008202169.1 658 0 PREDICTED: Tribolium castaneum maternal protein pumilio (LOC656229), transcript variant X4, mRNA K17943 PUM pumilio RNA-binding family http://www.genome.jp/dbget-bin/www_bget?ko:K17943 Q8TB72 1587 1.9e-174 Pumilio homolog 2 OS=Homo sapiens GN=PUM2 PE=1 SV=2 PF08144//PF00806//PF02422 CPL (NUC119) domain//Pumilio-family RNA binding repeat//Keratin -- -- GO:0003723//GO:0005200 RNA binding//structural constituent of cytoskeleton GO:0005856//GO:0005882 cytoskeleton//intermediate filament KOG1488 Translational repressor Pumilio/PUF3 and related RNA-binding proteins (Puf superfamily) Cluster-8309.484 BF_2 8.15 0.90 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48407 BF_2 624.46 7.40 3815 642935249 XP_008197930.1 1729 8.0e-190 PREDICTED: cdk10/11-like protein isoform X1 [Tribolium castaneum] 808133727 XM_012313986.1 209 1.13761e-102 PREDICTED: Bombus terrestris cyclin-dependent kinase 11B (LOC100650971), transcript variant X6, mRNA K08818 CDC2L cell division cycle 2-like http://www.genome.jp/dbget-bin/www_bget?ko:K08818 Q9VPC0 1397 1.0e-152 Serine/threonine-protein kinase PITSLRE OS=Drosophila melanogaster GN=Pitslre PE=1 SV=1 PF00069//PF01166//PF07714//PF05324 Protein kinase domain//TSC-22/dip/bun family//Protein tyrosine kinase//Sperm antigen HE2 GO:0006355//GO:0006468 regulation of transcription, DNA-templated//protein phosphorylation GO:0005524//GO:0003700//GO:0004672 ATP binding//transcription factor activity, sequence-specific DNA binding//protein kinase activity GO:0005576//GO:0005667 extracellular region//transcription factor complex -- -- Cluster-8309.48409 BF_2 76.48 1.04 3378 642915652 XP_008190697.1 1174 1.6e-125 PREDICTED: integrin-alpha FG-GAP repeat-containing protein 2-like [Tribolium castaneum] -- -- -- -- -- K09648 IMP2 mitochondrial inner membrane protease subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09648 Q6AZD4 491 1.0e-47 Mitochondrial inner membrane protease subunit 2 OS=Danio rerio GN=immp2l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1568 Mitochondrial inner membrane protease, subunit IMP2 Cluster-8309.48411 BF_2 664.62 20.15 1667 642918656 XP_008191524.1 1896 1.5e-209 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 1716 4.6e-190 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004672//GO:0004674//GO:0005543//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//phospholipid binding//ATP binding -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.48414 BF_2 14.05 0.47 1533 642936242 XP_008198362.1 1627 2.2e-178 PREDICTED: polypyrimidine tract-binding protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 781 1.1e-81 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.48415 BF_2 261.56 2.58 4534 270013160 EFA09608.1 920 6.2e-96 hypothetical protein TcasGA2_TC011728 [Tribolium castaneum] 642936249 XM_008200144.1 221 2.88982e-109 PREDICTED: Tribolium castaneum polypyrimidine tract-binding protein 1 (LOC654951), transcript variant X5, mRNA K14948 PTBP2, NPTB polypyrimidine tract-binding protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14948 Q00438 675 6.5e-69 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF08675//PF01405//PF00076 RNA binding domain//Photosystem II reaction centre T protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0051252//GO:0006402//GO:0015979 regulation of RNA metabolic process//mRNA catabolic process//photosynthesis GO:0004535//GO:0003676//GO:0046872//GO:0003723 poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding//RNA binding GO:0016020//GO:0009539//GO:0005737//GO:0009523//GO:0005634 membrane//photosystem II reaction center//cytoplasm//photosystem II//nucleus KOG1190 Polypyrimidine tract-binding protein Cluster-8309.48416 BF_2 101.73 4.29 1278 642936244 XP_008198363.1 1656 7.8e-182 PREDICTED: polypyrimidine tract-binding protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K13218 PTBP1, PTB polypyrimidine tract-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13218 Q00438 769 2.3e-80 Polypyrimidine tract-binding protein 1 OS=Rattus norvegicus GN=Ptbp1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1190 Polypyrimidine tract-binding protein Cluster-8309.48417 BF_2 33.52 0.62 2561 642926885 XP_972226.3 1431 1.9e-155 PREDICTED: merlin [Tribolium castaneum] 768439449 XM_011563053.1 208 2.73578e-102 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K16684 NF2 merlin http://www.genome.jp/dbget-bin/www_bget?ko:K16684 Q24564 1023 1.6e-109 Moesin/ezrin/radixin homolog 2 OS=Drosophila melanogaster GN=Mer PE=1 SV=1 PF00887//PF00487 Acyl CoA binding protein//Fatty acid desaturase GO:0006629 lipid metabolic process GO:0000062 fatty-acyl-CoA binding -- -- KOG3529 Radixin, moesin and related proteins of the ERM family Cluster-8309.48418 BF_2 32.84 0.40 3732 332376995 AEE63637.1 1603 3.2e-175 unknown [Dendroctonus ponderosae]>gi|478252044|gb|ENN72475.1| hypothetical protein YQE_10817, partial [Dendroctonus ponderosae] 768439449 XM_011563053.1 201 3.11546e-98 PREDICTED: Plutella xylostella merlin-like (LOC105391564), mRNA K04712 DEGS sphingolipid delta-4 desaturase http://www.genome.jp/dbget-bin/www_bget?ko:K04712 Q3ZBY7 1091 3.1e-117 Sphingolipid delta(4)-desaturase DES1 OS=Bos taurus GN=DEGS1 PE=2 SV=1 PF00487//PF00887 Fatty acid desaturase//Acyl CoA binding protein GO:0006629 lipid metabolic process GO:0000062 fatty-acyl-CoA binding -- -- KOG2987 Fatty acid desaturase Cluster-8309.48420 BF_2 8.00 7.80 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48421 BF_2 565.68 2.82 8679 560135523 CDJ84245.1 2273 1.5e-252 Protein of unknown function DUF889 domain containing protein [Haemonchus contortus] -- -- -- -- -- -- -- -- -- Q7ZV90 255 6.3e-20 ATP-dependent DNA helicase PIF1 OS=Danio rerio GN=pif1 PE=2 SV=1 PF02689//PF01443//PF05970 Helicase//Viral (Superfamily 1) RNA helicase//PIF1-like helicase GO:0000723//GO:0006281 telomere maintenance//DNA repair GO:0005524//GO:0003678//GO:0004386 ATP binding//DNA helicase activity//helicase activity GO:0005657 replication fork -- -- Cluster-8309.48425 BF_2 21.00 1.44 896 478254217 ENN74482.1 186 1.6e-11 hypothetical protein YQE_08928, partial [Dendroctonus ponderosae]>gi|546675251|gb|ERL86487.1| hypothetical protein D910_03891 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P23625 144 4.8e-08 G protein alpha q subunit OS=Drosophila melanogaster GN=Galphaq PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0085 G protein subunit Galphaq/Galphay, small G protein superfamily Cluster-8309.48427 BF_2 85.01 1.37 2886 91081333 XP_976019.1 2826 0.0e+00 PREDICTED: probable phosphorylase b kinase regulatory subunit alpha isoform X1 [Tribolium castaneum] -- -- -- -- -- K07190 PHKA_B phosphorylase kinase alpha/beta subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07190 Q9W391 2119 1.5e-236 Probable phosphorylase b kinase regulatory subunit alpha OS=Drosophila melanogaster GN=CG7766 PE=1 SV=2 PF07525//PF17050 SOCS box//Altered inheritance of mitochondria 5 GO:0042407//GO:0035556 cristae formation//intracellular signal transduction -- -- GO:0044284//GO:0061617 mitochondrial crista junction//MICOS complex KOG3635 Phosphorylase kinase Cluster-8309.48434 BF_2 184.95 3.83 2309 -- -- -- -- -- 642920079 XM_001815999.2 51 4.64791e-15 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48435 BF_2 94.05 1.91 2352 -- -- -- -- -- 642920079 XM_001815999.2 51 4.7358e-15 PREDICTED: Tribolium castaneum uncharacterized LOC100142030 (LOC100142030), mRNA -- -- -- -- -- -- -- -- PF02751 Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.48436 BF_2 17.82 0.37 2314 478253824 ENN74116.1 509 1.4e-48 hypothetical protein YQE_09089, partial [Dendroctonus ponderosae]>gi|546684629|gb|ERL94246.1| hypothetical protein D910_11527 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B9VTT2 299 1.3e-25 Rho GTPase-activating protein 7 OS=Canis familiaris GN=DLC1 PE=2 SV=1 PF03121 Herpesviridae UL52/UL70 DNA primase GO:0006351//GO:0006260//GO:0006269 transcription, DNA-templated//DNA replication//DNA replication, synthesis of RNA primer GO:0003896 DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork -- -- Cluster-8309.48438 BF_2 195.50 1.90 4589 390362249 XP_001190749.2 841 9.0e-87 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 831 5.4e-87 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.48439 BF_2 16.36 0.34 2275 817061123 XP_012252151.1 291 2.7e-23 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04147 Nop14-like family -- -- -- -- GO:0032040 small-subunit processome -- -- Cluster-8309.48443 BF_2 280.00 18.63 916 478253497 ENN73824.1 519 3.9e-50 hypothetical protein YQE_09602, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9V3W6 304 1.4e-26 Innexin inx7 OS=Drosophila melanogaster GN=Inx7 PE=2 SV=1 PF00876//PF01553 Innexin//Acyltransferase GO:0008152 metabolic process GO:0016746 transferase activity, transferring acyl groups GO:0005921 gap junction -- -- Cluster-8309.48447 BF_2 86.99 1.92 2182 91088603 XP_973741.1 2119 2.8e-235 PREDICTED: sodium-dependent nutrient amino acid transporter 1 [Tribolium castaneum]>gi|642931940|ref|XP_008196786.1| PREDICTED: sodium-dependent nutrient amino acid transporter 1 [Tribolium castaneum]>gi|270012259|gb|EFA08707.1| hypothetical protein TcasGA2_TC006378 [Tribolium castaneum] 602654660 XM_007433088.1 38 7.39536e-08 PREDICTED: Python bivittatus solute carrier family 6 (neurotransmitter transporter), member 2 (SLC6A2), mRNA K05038 SLC6A5S solute carrier family 6 (neurotransmitter transporter, amino acid) member 5/7/9/14 http://www.genome.jp/dbget-bin/www_bget?ko:K05038 B4GVM9 1489 1.3e-163 Sodium-dependent nutrient amino acid transporter 1 OS=Drosophila persimilis GN=NAAT1 PE=3 SV=1 PF08447//PF00209 PAS fold//Sodium:neurotransmitter symporter family GO:0006810//GO:0006836//GO:0006812 transport//neurotransmitter transport//cation transport GO:0005328//GO:0005515//GO:0015293 neurotransmitter:sodium symporter activity//protein binding//symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.48448 BF_2 196.65 8.35 1272 189241858 XP_971116.2 1391 4.2e-151 PREDICTED: phosphatidylinositol 4,5-bisphosphate 5-phosphatase A-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 P59644 534 4.1e-53 Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A OS=Mus musculus GN=Inpp5j PE=2 SV=2 PF06330 Trichodiene synthase (TRI5) GO:0016114//GO:0016106 terpenoid biosynthetic process//sesquiterpenoid biosynthetic process GO:0045482 trichodiene synthase activity -- -- -- -- Cluster-8309.48451 BF_2 89.06 0.96 4172 270015450 EFA11898.1 376 6.8e-33 hypothetical protein TcasGA2_TC001429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07646 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48460 BF_2 363.90 1.53 10245 478256576 ENN76758.1 3630 0.0e+00 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- K10395 KIF4_21_27 kinesin family member 4/21/27 http://www.genome.jp/dbget-bin/www_bget?ko:K10395 Q7Z4S6 1645 4.9e-181 Kinesin-like protein KIF21A OS=Homo sapiens GN=KIF21A PE=1 SV=2 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule KOG0244 Kinesin-like protein Cluster-8309.48461 BF_2 175.55 2.70 3010 642927168 XP_008195164.1 1378 3.2e-149 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZI58 629 9.3e-64 Protein FAM214A OS=Gallus gallus GN=FAM214A PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2306 Uncharacterized conserved protein Cluster-8309.48463 BF_2 254.48 0.98 11174 91079222 XP_970170.1 5671 0.0e+00 PREDICTED: calcineurin-binding protein cabin-1 [Tribolium castaneum]>gi|270004269|gb|EFA00717.1| hypothetical protein TcasGA2_TC003597 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P08043 714 4.8e-73 Zinc finger protein 2 OS=Mus musculus GN=Zfp2 PE=2 SV=2 PF00096//PF03608//PF04882//PF04828//PF00320//PF01363//PF13912//PF17051//PF13414//PF13465//PF13176//PF05191//PF16622//PF02892//PF00515//PF09726 Zinc finger, C2H2 type//PTS system enzyme II sorbitol-specific factor//Peroxin-3//Glutathione-dependent formaldehyde-activating enzyme//GATA zinc finger//FYVE zinc finger//C2H2-type zinc finger//Cytochrome C oxidase assembly factor 2//TPR repeat//Zinc-finger double domain//Tetratricopeptide repeat//Adenylate kinase, active site lid//zinc-finger C2H2-type//BED zinc finger//Tetratricopeptide repeat//Transmembrane protein GO:0046034//GO:0006355//GO:0009401//GO:0008152//GO:0007031//GO:0006144//GO:0033617 ATP metabolic process//regulation of transcription, DNA-templated//phosphoenolpyruvate-dependent sugar phosphotransferase system//metabolic process//peroxisome organization//purine nucleobase metabolic process//mitochondrial respiratory chain complex IV assembly GO:0016846//GO:0008270//GO:0043565//GO:0003700//GO:0004017//GO:0003677//GO:0005515//GO:0046872 carbon-sulfur lyase activity//zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//adenylate kinase activity//DNA binding//protein binding//metal ion binding GO:0016021//GO:0005779//GO:0005667 integral component of membrane//integral component of peroxisomal membrane//transcription factor complex -- -- Cluster-8309.48465 BF_2 82.11 1.95 2046 642933823 XP_008197408.1 1644 3.1e-180 PREDICTED: formin-2 [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 776 5.7e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019031//GO:0019028 viral envelope//viral capsid KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.48467 BF_2 267.65 1.68 6949 546684555 ERL94183.1 5857 0.0e+00 hypothetical protein D910_11465 [Dendroctonus ponderosae] 642931708 XM_008198474.1 214 3.45619e-105 PREDICTED: Tribolium castaneum golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (LOC655455), mRNA K18443 GBF1 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18443 Q9R1D7 1809 3.2e-200 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Cricetulus griseus GN=GBF1 PE=1 SV=1 PF00001//PF01369 7 transmembrane receptor (rhodopsin family)//Sec7 domain GO:0043087//GO:0032012//GO:0007186 regulation of GTPase activity//regulation of ARF protein signal transduction//G-protein coupled receptor signaling pathway GO:0005086//GO:0004930 ARF guanyl-nucleotide exchange factor activity//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG0928 Pattern-formation protein/guanine nucleotide exchange factor Cluster-8309.48468 BF_2 1893.49 12.20 6779 546684555 ERL94183.1 5855 0.0e+00 hypothetical protein D910_11465 [Dendroctonus ponderosae] 642931708 XM_008198474.1 214 3.37118e-105 PREDICTED: Tribolium castaneum golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 (LOC655455), mRNA K18443 GBF1 golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18443 Q9R1D7 1809 3.1e-200 Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 OS=Cricetulus griseus GN=GBF1 PE=1 SV=1 PF01369 Sec7 domain GO:0043087//GO:0032012 regulation of GTPase activity//regulation of ARF protein signal transduction GO:0005086 ARF guanyl-nucleotide exchange factor activity -- -- KOG0928 Pattern-formation protein/guanine nucleotide exchange factor Cluster-8309.48469 BF_2 69.24 2.86 1301 478250432 ENN70927.1 524 1.5e-50 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 438 5.6e-42 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656//PF00522 Caspase domain//VPR/VPX protein GO:0006508//GO:0019058 proteolysis//viral life cycle GO:0004197 cysteine-type endopeptidase activity GO:0042025 host cell nucleus -- -- Cluster-8309.48470 BF_2 1.00 0.63 349 642913381 XP_008195471.1 189 2.7e-12 PREDICTED: double-strand-break repair protein rad21 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48472 BF_2 561.00 8.52 3041 478254047 ENN74339.1 1183 1.3e-126 hypothetical protein YQE_09309, partial [Dendroctonus ponderosae]>gi|546686139|gb|ERL95525.1| hypothetical protein D910_12787 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A9ZSY3 680 1.1e-69 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF07284//PF07690//PF03137//PF00083 2-vinyl bacteriochlorophyllide hydratase (BCHF)//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Sugar (and other) transporter GO:0055085//GO:0019685//GO:0006810//GO:0030494 transmembrane transport//photosynthesis, dark reaction//transport//bacteriochlorophyll biosynthetic process GO:0022857//GO:0016836//GO:0005215 transmembrane transporter activity//hydro-lyase activity//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.48475 BF_2 266.60 3.42 3547 642915923 XP_008190812.1 3396 0.0e+00 PREDICTED: protein retinal degeneration B isoform X4 [Tribolium castaneum] 642915920 XM_008192589.1 55 4.2872e-17 PREDICTED: Tribolium castaneum protein retinal degeneration B (LOC655106), transcript variant X5, mRNA -- -- -- -- P43125 2320 9.1e-260 Protein retinal degeneration B OS=Drosophila melanogaster GN=rdgB PE=1 SV=2 PF03767//PF02862 HAD superfamily, subfamily IIIB (Acid phosphatase)//DDHD domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0003993 metal ion binding//acid phosphatase activity -- -- KOG2308 Phosphatidic acid-preferring phospholipase A1, contains DDHD domain Cluster-8309.48478 BF_2 3.00 21.69 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48479 BF_2 88.14 1.33 3069 741829513 AJA91072.1 1502 1.4e-163 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P33270 1028 5.1e-110 Cytochrome P450 6a2 OS=Drosophila melanogaster GN=Cyp6a2 PE=2 SV=2 PF01830//PF00067//PF01297 Peptidase C7 family//Cytochrome P450//Zinc-uptake complex component A periplasmic GO:0030001//GO:0006508//GO:0055114 metal ion transport//proteolysis//oxidation-reduction process GO:0016705//GO:0004197//GO:0020037//GO:0046872//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//cysteine-type endopeptidase activity//heme binding//metal ion binding//iron ion binding -- -- -- -- Cluster-8309.48481 BF_2 214.63 1.92 4965 642932399 XP_001812551.2 1590 1.4e-173 PREDICTED: uncharacterized protein LOC100142041 [Tribolium castaneum] 642932398 XM_001812499.2 48 4.68576e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142041 (LOC100142041), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 P46152 200 8.5e-14 Transcription factor GATA-4 OS=Rattus norvegicus GN=Gata4 PE=1 SV=1 PF00320//PF07776//PF00979 GATA zinc finger//Zinc-finger associated domain (zf-AD)//Reovirus outer capsid protein, Sigma 3 GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005198//GO:0003700//GO:0043565//GO:0008270 structural molecule activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.48482 BF_2 405.64 3.61 4987 642932399 XP_001812551.2 1585 5.2e-173 PREDICTED: uncharacterized protein LOC100142041 [Tribolium castaneum] 642932398 XM_001812499.2 48 4.70668e-13 PREDICTED: Tribolium castaneum uncharacterized LOC100142041 (LOC100142041), mRNA K17895 GATA3 GATA-binding protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17895 P43694 207 1.3e-14 Transcription factor GATA-4 OS=Homo sapiens GN=GATA4 PE=1 SV=2 PF00979//PF00320//PF07776 Reovirus outer capsid protein, Sigma 3//GATA zinc finger//Zinc-finger associated domain (zf-AD) GO:0019058//GO:0006355 viral life cycle//regulation of transcription, DNA-templated GO:0005198//GO:0003700//GO:0008270//GO:0043565 structural molecule activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.48484 BF_2 5.00 0.35 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48485 BF_2 67.42 0.45 6542 91089043 XP_969794.1 4704 0.0e+00 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] 657579724 XM_008295570.1 270 2.40998e-136 PREDICTED: Stegastes partitus regulatory associated protein of MTOR, complex 1 (rptor), mRNA K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8N122 3158 0.0e+00 Regulatory-associated protein of mTOR OS=Homo sapiens GN=RPTOR PE=1 SV=1 PF06384//PF02985//PF00400 Beta-catenin-interacting protein ICAT//HEAT repeat//WD domain, G-beta repeat -- -- GO:0005515//GO:0008013 protein binding//beta-catenin binding GO:0016342 catenin complex KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.48487 BF_2 78.19 0.43 7864 478255473 ENN75692.1 1601 1.2e-174 hypothetical protein YQE_07754, partial [Dendroctonus ponderosae] 642937067 XM_008200455.1 308 2.1791e-157 PREDICTED: Tribolium castaneum collagen alpha chain CG42342 (LOC659070), transcript variant X4, mRNA -- -- -- -- B7Z0K8 216 1.9e-15 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 PF01757//PF17123//PF17122//PF13639 Acyltransferase family//RING-like zinc finger//Zinc-finger//Ring finger domain -- -- GO:0005515//GO:0016747//GO:0008270 protein binding//transferase activity, transferring acyl groups other than amino-acyl groups//zinc ion binding -- -- -- -- Cluster-8309.48488 BF_2 120.36 0.65 8019 642937088 XP_008198687.1 1740 9.0e-191 PREDICTED: nose resistant to fluoxetine protein 6 isoform X1 [Tribolium castaneum]>gi|270000892|gb|EEZ97339.1| hypothetical protein TcasGA2_TC011151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B7Z0K8 181 2.2e-11 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 PF13639//PF01757//PF17123//PF17122 Ring finger domain//Acyltransferase family//RING-like zinc finger//Zinc-finger -- -- GO:0016747//GO:0005515//GO:0008270 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//zinc ion binding -- -- -- -- Cluster-8309.48489 BF_2 332.47 2.05 7075 642918656 XP_008191524.1 2229 1.6e-247 PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|642918658|ref|XP_008191525.1| PREDICTED: RAC serine/threonine-protein kinase [Tribolium castaneum]>gi|270005657|gb|EFA02105.1| hypothetical protein TcasGA2_TC007749 [Tribolium castaneum] -- -- -- -- -- K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 Q8INB9 2003 1.0e-222 RAC serine/threonine-protein kinase OS=Drosophila melanogaster GN=Akt1 PE=1 SV=3 PF01799//PF00433//PF07714//PF00069//PF00463 [2Fe-2S] binding domain//Protein kinase C terminal domain//Protein tyrosine kinase//Protein kinase domain//Isocitrate lyase family GO:0006468//GO:0009069//GO:0019752//GO:0016310//GO:0006097//GO:0055114 protein phosphorylation//serine family amino acid metabolic process//carboxylic acid metabolic process//phosphorylation//glyoxylate cycle//oxidation-reduction process GO:0005543//GO:0016491//GO:0004451//GO:0005524//GO:0004672//GO:0046872//GO:0004674 phospholipid binding//oxidoreductase activity//isocitrate lyase activity//ATP binding//protein kinase activity//metal ion binding//protein serine/threonine kinase activity -- -- KOG0690 Serine/threonine protein kinase Cluster-8309.48491 BF_2 1657.94 11.94 6096 642937213 XP_008198742.1 1736 2.0e-190 PREDICTED: activin receptor type-2A [Tribolium castaneum]>gi|270001287|gb|EEZ97734.1| punt [Tribolium castaneum] 852789879 XM_013030253.1 144 2.47964e-66 PREDICTED: Dipodomys ordii activin A receptor, type IIB (Acvr2b), mRNA K13596 ACVR2B activin receptor type-2B http://www.genome.jp/dbget-bin/www_bget?ko:K13596 P27039 1135 4.0e-122 Activin receptor type-2A OS=Xenopus laevis GN=acvr2a PE=2 SV=1 PF16782//PF01064//PF00069//PF07714 Nucleotide exchange factor SIL1//Activin types I and II receptor domain//Protein kinase domain//Protein tyrosine kinase GO:0007178//GO:0016310//GO:0006468//GO:0009069 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0000774//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//adenyl-nucleotide exchange factor activity//protein kinase activity//ATP binding GO:0016020//GO:0005783 membrane//endoplasmic reticulum -- -- Cluster-8309.48492 BF_2 14.59 0.42 1743 91079768 XP_966889.1 821 7.1e-85 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 310 5.3e-27 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0050662//GO:0003824//GO:0000166 oxidoreductase activity//coenzyme binding//catalytic activity//nucleotide binding -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.48493 BF_2 463.00 35.48 833 642917962 XP_008198961.1 846 4.3e-88 PREDICTED: probable phospholipid hydroperoxide glutathione peroxidase [Tribolium castaneum]>gi|270004924|gb|EFA01372.1| hypothetical protein TcasGA2_TC010362 [Tribolium castaneum] 512938538 XM_004933972.1 53 1.26286e-16 PREDICTED: Bombyx mori phospholipid hydroperoxide glutathione peroxidase, mitochondrial-like (LOC101744684), partial mRNA K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q32QL6 485 1.3e-47 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial OS=Callithrix jacchus GN=GPX4 PE=2 SV=2 PF00255//PF00578//PF11095//PF08534 Glutathione peroxidase//AhpC/TSA family//Gem-associated protein 7 (Gemin7)//Redoxin GO:0006804//GO:0006979//GO:0006749//GO:0055114 obsolete peroxidase reaction//response to oxidative stress//glutathione metabolic process//oxidation-reduction process GO:0016491//GO:0004602//GO:0016209 oxidoreductase activity//glutathione peroxidase activity//antioxidant activity GO:0032797 SMN complex KOG1651 Glutathione peroxidase Cluster-8309.48498 BF_2 29.88 0.84 1770 642928567 XP_008199961.1 576 1.9e-56 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 384 1.4e-35 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.48500 BF_2 9.00 0.38 1290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48503 BF_2 34.00 6.11 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48504 BF_2 703.50 7.44 4244 642910515 XP_971774.3 2651 1.1e-296 PREDICTED: leucine-rich repeats and immunoglobulin-like domains protein 2 isoform X2 [Tribolium castaneum]>gi|270014383|gb|EFA10831.1| hypothetical protein TcasGA2_TC001607 [Tribolium castaneum] 642910514 XM_966681.3 50 3.09246e-14 PREDICTED: Tribolium castaneum leucine-rich repeats and immunoglobulin-like domains protein 2 (LOC660451), transcript variant X2, mRNA -- -- -- -- Q52KR2 1478 4.7e-162 Leucine-rich repeats and immunoglobulin-like domains protein 2 OS=Mus musculus GN=Lrig2 PE=1 SV=1 PF13895//PF13855//PF06667//PF00560//PF02924//PF05790 Immunoglobulin domain//Leucine rich repeat//Phage shock protein B//Leucine Rich Repeat//Bacteriophage lambda head decoration protein D//Immunoglobulin C2-set domain GO:0007155//GO:0006355//GO:0009271 cell adhesion//regulation of transcription, DNA-templated//phage shock GO:0005515 protein binding GO:0019028//GO:0016021 viral capsid//integral component of membrane KOG4194 Membrane glycoprotein LIG-1 Cluster-8309.48505 BF_2 222.82 3.95 2649 751425407 AJF93909.1 2405 2.3e-268 FTZ F1 beta [Leptinotarsa decemlineata] 642917898 XM_008193153.1 817 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1653 1.5e-182 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00105//PF00104//PF00288 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor//GHMP kinases N terminal domain GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0005524//GO:0003700//GO:0008270//GO:0043565 ATP binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.48506 BF_2 1.00 5.48 250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48507 BF_2 16.09 0.47 1716 642932088 XP_975105.3 656 9.5e-66 PREDICTED: acid phosphatase-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IHQ9 220 1.4e-16 2-phosphoxylose phosphatase 1 OS=Xenopus tropicalis GN=pxylp1 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3672 Histidine acid phosphatase Cluster-8309.48509 BF_2 47.05 0.60 3585 546677956 ERL88689.1 429 4.2e-39 hypothetical protein D910_06072 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03547//PF05485 Membrane transport protein//THAP domain GO:0055085 transmembrane transport GO:0003676 nucleic acid binding GO:0016021 integral component of membrane -- -- Cluster-8309.48511 BF_2 502.00 16.09 1592 332374872 AEE62577.1 1421 1.7e-154 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03843 ALG2 alpha-1,3/alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03843 Q9H553 880 3.9e-93 Alpha-1,3/1,6-mannosyltransferase ALG2 OS=Homo sapiens GN=ALG2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0853 Glycosyltransferase Cluster-8309.48512 BF_2 498.00 99.68 496 668465859 KFB52933.1 491 3.7e-47 AGAP005873-PA-like protein [Anopheles sinensis] 242007912 XM_002424715.1 111 4.1928e-49 Pediculus humanus corporis DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide, putative, mRNA K03014 RPB6, POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03014 Q24320 469 5.5e-46 DNA-directed RNA polymerases I, II, and III subunit RPABC2 OS=Drosophila melanogaster GN=RpII18 PE=2 SV=1 PF01192 RNA polymerase Rpb6 GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG3405 RNA polymerase subunit K Cluster-8309.48516 BF_2 15.53 1.31 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48518 BF_2 287.30 2.58 4939 270014603 EFA11051.1 3563 0.0e+00 hypothetical protein TcasGA2_TC004645 [Tribolium castaneum] 195445683 XM_002070402.1 103 1.24209e-43 Drosophila willistoni GK12058 (Dwil\GK12058), mRNA K16667 PTPRG receptor-type tyrosine-protein phosphatase gamma http://www.genome.jp/dbget-bin/www_bget?ko:K16667 P35832 2408 7.9e-270 Tyrosine-protein phosphatase 99A OS=Drosophila melanogaster GN=Ptp99A PE=2 SV=2 PF00041//PF00102//PF00782 Fibronectin type III domain//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0005515//GO:0008138 protein tyrosine phosphatase activity//protein binding//protein tyrosine/serine/threonine phosphatase activity -- -- -- -- Cluster-8309.48522 BF_2 43.35 0.35 5502 642939323 XP_969087.2 928 8.8e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.76952e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF01588 Putative tRNA binding domain -- -- GO:0000049 tRNA binding -- -- KOG2241 tRNA-binding protein Cluster-8309.48524 BF_2 30.47 1.62 1072 270004118 EFA00566.1 451 3.5e-42 hypothetical protein TcasGA2_TC003436 [Tribolium castaneum] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 399 1.5e-37 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.48526 BF_2 618.49 2.17 12221 642938657 XP_008197674.1 3758 0.0e+00 PREDICTED: probable G-protein coupled receptor 125 [Tribolium castaneum] -- -- -- -- -- K09478 ACADSB short/branched chain acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09478 P45954 1254 1.3e-135 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial OS=Homo sapiens GN=ACADSB PE=1 SV=1 PF02793//PF01825//PF00441//PF13895//PF13855//PF02771//PF02770//PF00002 Hormone receptor domain//GPCR proteolysis site, GPS, motif//Acyl-CoA dehydrogenase, C-terminal domain//Immunoglobulin domain//Leucine rich repeat//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, middle domain//7 transmembrane receptor (Secretin family) GO:0055114//GO:0006118//GO:0007186//GO:0008152 oxidation-reduction process//obsolete electron transport//G-protein coupled receptor signaling pathway//metabolic process GO:0016627//GO:0050660//GO:0005515//GO:0003995//GO:0004930 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//protein binding//acyl-CoA dehydrogenase activity//G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0139 Short-chain acyl-CoA dehydrogenase Cluster-8309.48528 BF_2 38.24 0.32 5300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48530 BF_2 123.16 1.14 4809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48531 BF_2 120.68 12.05 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48532 BF_2 285.50 5.18 2593 -- -- -- -- -- 642924278 XM_008196007.1 103 6.48227e-44 PREDICTED: Tribolium castaneum uncharacterized LOC103313241 (LOC103313241), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF07645//PF00008//PF13895//PF08040 Calcium-binding EGF domain//EGF-like domain//Immunoglobulin domain//MNLL subunit GO:0006118 obsolete electron transport GO:0005509//GO:0005515//GO:0003954 calcium ion binding//protein binding//NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-8309.48535 BF_2 50.00 1.72 1505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48537 BF_2 45.11 1.49 1553 642918172 XP_008191396.1 358 3.1e-31 PREDICTED: uncharacterized protein LOC103312474 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ46 170 8.0e-11 EF-hand calcium-binding domain-containing protein 2 OS=Mus musculus GN=Efcab2 PE=2 SV=1 PF03982//PF03145 Diacylglycerol acyltransferase//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0005634 nucleus -- -- Cluster-8309.48545 BF_2 259.32 2.28 5047 546671406 ERL83731.1 3164 0.0e+00 hypothetical protein D910_00944, partial [Dendroctonus ponderosae]>gi|546675549|gb|ERL86722.1| hypothetical protein D910_04128, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24247 1688 2.5e-186 Integrin alpha-PS1 OS=Drosophila melanogaster GN=mew PE=1 SV=2 PF06529 Vertebrate interleukin-3 regulated transcription factor GO:0006351//GO:0007623 transcription, DNA-templated//circadian rhythm -- -- GO:0005634 nucleus KOG3637 Vitronectin receptor, alpha subunit Cluster-8309.48547 BF_2 59.20 0.62 4272 642925057 XP_008194153.1 5222 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X4 [Tribolium castaneum] 874475179 XM_013100081.1 39 4.05555e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1813 6.7e-201 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.48550 BF_2 362.91 8.64 2045 751799211 XP_011209556.1 727 6.7e-74 PREDICTED: methyltransferase-like protein 23 [Bactrocera dorsalis] -- -- -- -- -- -- -- -- -- Q5U312 190 5.1e-13 Ankycorbin OS=Rattus norvegicus GN=Rai14 PE=2 SV=2 PF00887//PF13606//PF00023//PF16367//PF06839//PF00076//PF06177 Acyl CoA binding protein//Ankyrin repeat//Ankyrin repeat//RNA recognition motif//GRF zinc finger//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//QueT transporter -- -- GO:0008270//GO:0000062//GO:0003676//GO:0005515 zinc ion binding//fatty-acyl-CoA binding//nucleic acid binding//protein binding GO:0005886 plasma membrane -- -- Cluster-8309.48551 BF_2 95.14 1.25 3466 270008217 EFA04665.1 679 4.1e-68 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 Q9VA27 492 8.2e-48 Cytochrome P450 4c3 OS=Drosophila melanogaster GN=Cyp4c3 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.48552 BF_2 73.22 12.82 526 642935292 XP_008197953.1 581 1.4e-57 PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X4 [Tribolium castaneum]>gi|642935294|ref|XP_008197954.1| PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X4 [Tribolium castaneum]>gi|642935296|ref|XP_008197955.1| PREDICTED: CAP-Gly domain-containing linker protein 1 isoform X4 [Tribolium castaneum] 705662443 XM_010129333.1 45 2.17746e-12 PREDICTED: Chlamydotis macqueenii CAP-GLY domain containing linker protein 1 (CLIP1), mRNA K10421 CLIP1, RSN CAP-Gly domain-containing linker protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10421 P30622 304 7.8e-27 CAP-Gly domain-containing linker protein 1 OS=Homo sapiens GN=CLIP1 PE=1 SV=2 PF08702//PF13949//PF05531//PF02185 Fibrinogen alpha/beta chain family//ALIX V-shaped domain binding to HIV//Nucleopolyhedrovirus P10 protein//Hr1 repeat GO:0030168//GO:0051258//GO:0007165 platelet activation//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0005515 receptor binding//protein binding, bridging//protein binding GO:0005577//GO:0019028 fibrinogen complex//viral capsid -- -- Cluster-8309.48553 BF_2 165.15 6.19 1404 189234028 XP_973216.2 1787 5.6e-197 PREDICTED: dual specificity mitogen-activated protein kinase kinase dSOR1 [Tribolium castaneum]>gi|270014747|gb|EFA11195.1| hypothetical protein TcasGA2_TC004803 [Tribolium castaneum] -- -- -- -- -- K04368 MAP2K1, MEK1 mitogen-activated protein kinase kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04368 Q24324 1479 1.2e-162 Dual specificity mitogen-activated protein kinase kinase dSOR1 OS=Drosophila melanogaster GN=Dsor1 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0581 Mitogen-activated protein kinase kinase (MAP2K) Cluster-8309.48556 BF_2 27.00 10.72 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48561 BF_2 94.54 0.96 4412 270003550 EEZ99997.1 329 2.0e-27 hypothetical protein TcasGA2_TC002800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NEL2 155 1.3e-08 Ankyrin repeat domain-containing protein SOWAHB OS=Homo sapiens GN=SOWAHB PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.48563 BF_2 62.89 0.46 5994 642916731 XP_008192389.1 645 6.3e-64 PREDICTED: uncharacterized protein LOC103312734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48564 BF_2 292.67 1.32 9559 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 6.20281e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF00071//PF01411//PF02272//PF01018//PF00400//PF01399//PF02421//PF00025//PF07973//PF01343//PF01926 Ras family//tRNA synthetases class II (A)//DHHA1 domain//GTP1/OBG//WD domain, G-beta repeat//PCI domain//Ferrous iron transport protein B//ADP-ribosylation factor family//Threonyl and Alanyl tRNA synthetase second additional domain//Peptidase family S49//50S ribosome-binding GTPase GO:0015684//GO:0006508//GO:0006522//GO:0006413//GO:0007264//GO:0043039//GO:0006419//GO:0006446//GO:0006531 ferrous iron transport//proteolysis//alanine metabolic process//translational initiation//small GTPase mediated signal transduction//tRNA aminoacylation//alanyl-tRNA aminoacylation//regulation of translational initiation//aspartate metabolic process GO:0000166//GO:0016876//GO:0008233//GO:0003743//GO:0005524//GO:0003676//GO:0005525//GO:0015093//GO:0005515//GO:0004813 nucleotide binding//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//translation initiation factor activity//ATP binding//nucleic acid binding//GTP binding//ferrous iron transmembrane transporter activity//protein binding//alanine-tRNA ligase activity GO:0005840//GO:0005737//GO:0016021 ribosome//cytoplasm//integral component of membrane KOG0188 Alanyl-tRNA synthetase Cluster-8309.48565 BF_2 329.59 1.66 8598 91084029 XP_966465.1 4108 0.0e+00 PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|642924795|ref|XP_008194044.1| PREDICTED: alanine--tRNA ligase, cytoplasmic [Tribolium castaneum]>gi|270006700|gb|EFA03148.1| hypothetical protein TcasGA2_TC013061 [Tribolium castaneum] 440199242 JQ783618.1 203 5.57679e-99 Schreckensteinia sp. Sktn ala-tRNA synthetase mRNA, partial cds K01872 AARS, alaS alanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01872 Q9VLM8 3510 0.0e+00 Alanine--tRNA ligase, cytoplasmic OS=Drosophila melanogaster GN=Aats-ala PE=2 SV=1 PF01926//PF07973//PF01343//PF02421//PF00025//PF03193//PF00400//PF01399//PF00005//PF02272//PF01411//PF01018//PF00493//PF00071//PF01580 50S ribosome-binding GTPase//Threonyl and Alanyl tRNA synthetase second additional domain//Peptidase family S49//Ferrous iron transport protein B//ADP-ribosylation factor family//Protein of unknown function, DUF258//WD domain, G-beta repeat//PCI domain//ABC transporter//DHHA1 domain//tRNA synthetases class II (A)//GTP1/OBG//MCM2/3/5 family//Ras family//FtsK/SpoIIIE family GO:0015684//GO:0006260//GO:0006446//GO:0006531//GO:0006419//GO:0007264//GO:0043039//GO:0006522//GO:0006508//GO:0006413 ferrous iron transport//DNA replication//regulation of translational initiation//aspartate metabolic process//alanyl-tRNA aminoacylation//small GTPase mediated signal transduction//tRNA aminoacylation//alanine metabolic process//proteolysis//translational initiation GO:0003924//GO:0003743//GO:0005524//GO:0016876//GO:0008233//GO:0016887//GO:0000166//GO:0005515//GO:0004813//GO:0003677//GO:0015093//GO:0003676//GO:0005525 GTPase activity//translation initiation factor activity//ATP binding//ligase activity, forming aminoacyl-tRNA and related compounds//peptidase activity//ATPase activity//nucleotide binding//protein binding//alanine-tRNA ligase activity//DNA binding//ferrous iron transmembrane transporter activity//nucleic acid binding//GTP binding GO:0016021//GO:0005737//GO:0005840 integral component of membrane//cytoplasm//ribosome KOG0188 Alanyl-tRNA synthetase Cluster-8309.48566 BF_2 79.29 4.88 967 270010513 EFA06961.1 532 1.3e-51 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2TBG7 367 7.2e-34 Iron-sulfur cluster assembly 2 homolog, mitochondrial OS=Bos taurus GN=ISCA2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1119 Mitochondrial Fe-S cluster biosynthesis protein ISA2 (contains a HesB-like domain) Cluster-8309.48567 BF_2 223.20 3.44 3004 642927943 XP_008195456.1 2414 2.3e-269 PREDICTED: tetratricopeptide repeat protein 37 [Tribolium castaneum] -- -- -- -- -- K12600 SKI3, TTC37 superkiller protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12600 Q6PGP7 941 6.2e-100 Tetratricopeptide repeat protein 37 OS=Homo sapiens GN=TTC37 PE=1 SV=1 PF13414//PF13174//PF13176//PF13371//PF13181//PF13374//PF00515 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1127 TPR repeat-containing protein Cluster-8309.48571 BF_2 130.84 7.58 1009 642926280 XP_008194858.1 520 3.3e-50 PREDICTED: uncharacterized protein LOC103313420 isoform X1 [Tribolium castaneum]>gi|270008508|gb|EFA04956.1| hypothetical protein TcasGA2_TC015025 [Tribolium castaneum] 749773866 XM_011143969.1 84 9.0159e-34 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X1, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- PF01972 Serine dehydrogenase proteinase -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.48573 BF_2 3.32 0.57 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48576 BF_2 9.57 1.12 646 270015858 EFA12306.1 324 1.1e-27 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48577 BF_2 80.64 1.80 2164 270015858 EFA12306.1 324 3.8e-27 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48579 BF_2 18.00 2.51 587 72016467 XP_782887.1 302 3.6e-25 PREDICTED: ankyrin-1-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 272 4.5e-23 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.48580 BF_2 14.00 1.49 679 170053867 XP_001862871.1 152 1.0e-07 predicted protein [Culex quinquefasciatus]>gi|167874341|gb|EDS37724.1| predicted protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48581 BF_2 15.79 0.33 2291 270015858 EFA12306.1 324 4.0e-27 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48582 BF_2 32.00 0.98 1651 817061123 XP_012252151.1 475 8.9e-45 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00657//PF00448 GDSL-like Lipase/Acylhydrolase//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0016788 GTP binding//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.48583 BF_2 195.00 1.38 6216 390362249 XP_001190749.2 698 4.7e-70 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 662 2.9e-67 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00004//PF00448//PF00023//PF13606 ATPase family associated with various cellular activities (AAA)//SRP54-type protein, GTPase domain//Ankyrin repeat//Ankyrin repeat GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005515//GO:0005525//GO:0005524 protein binding//GTP binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.48585 BF_2 49.29 0.67 3387 91080139 XP_968438.1 3145 0.0e+00 PREDICTED: polyphosphoinositide phosphatase [Tribolium castaneum]>gi|270005661|gb|EFA02109.1| hypothetical protein TcasGA2_TC007753 [Tribolium castaneum] 755878609 XM_005184732.2 66 3.14088e-23 PREDICTED: Musca domestica polyphosphoinositide phosphatase (LOC101887510), mRNA -- -- -- -- Q91WF7 1924 7.2e-214 Polyphosphoinositide phosphatase OS=Mus musculus GN=Fig4 PE=1 SV=1 PF02383 SacI homology domain -- -- GO:0042578 phosphoric ester hydrolase activity -- -- KOG1888 Putative phosphoinositide phosphatase Cluster-8309.48587 BF_2 758.00 8.03 4234 642924505 XP_973263.2 4129 0.0e+00 PREDICTED: importin subunit beta-1 [Tribolium castaneum] -- -- -- -- -- K14293 KPNB1 importin subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14293 P70168 3109 0.0e+00 Importin subunit beta-1 OS=Mus musculus GN=Kpnb1 PE=1 SV=2 PF02985//PF03810//PF00514//PF11698 HEAT repeat//Importin-beta N-terminal domain//Armadillo/beta-catenin-like repeat//V-ATPase subunit H GO:0015991//GO:0006886 ATP hydrolysis coupled proton transport//intracellular protein transport GO:0008536//GO:0005515//GO:0016820 Ran GTPase binding//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain KOG1241 Karyopherin (importin) beta 1 Cluster-8309.48589 BF_2 87.00 3.20 1426 746842810 XP_011051628.1 144 1.9e-06 PREDICTED: neprilysin-11-like [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- Q22523 138 3.8e-07 Neprilysin-21 OS=Caenorhabditis elegans GN=nep-21 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.48590 BF_2 120.26 1.96 2850 478253706 ENN74005.1 643 5.1e-64 hypothetical protein YQE_09395, partial [Dendroctonus ponderosae]>gi|546678195|gb|ERL88885.1| hypothetical protein D910_06267 [Dendroctonus ponderosae] -- -- -- -- -- K01346 CELA2 pancreatic elastase II http://www.genome.jp/dbget-bin/www_bget?ko:K01346 Q7SIG2 182 6.0e-12 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF10186//PF02477//PF00089//PF04111//PF05837 Vacuolar sorting 38 and autophagy-related subunit 14//Nucleocapsid N protein//Trypsin//Autophagy protein Apg6//Centromere protein H (CENP-H) GO:0006508//GO:0051382//GO:0010508//GO:0006914 proteolysis//kinetochore assembly//positive regulation of autophagy//autophagy GO:0004252 serine-type endopeptidase activity GO:0000776//GO:0019013 kinetochore//viral nucleocapsid -- -- Cluster-8309.48591 BF_2 5.25 0.49 736 478258463 ENN78547.1 142 1.6e-06 hypothetical protein YQE_04986, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00865//PF06524//PF09026//PF04931 Osteopontin//NOA36 protein//Centromere protein B dimerisation domain//DNA polymerase phi GO:0006351//GO:0001503//GO:0007155//GO:0006355//GO:0006260 transcription, DNA-templated//ossification//cell adhesion//regulation of transcription, DNA-templated//DNA replication GO:0003677//GO:0003887//GO:0008270//GO:0003682 DNA binding//DNA-directed DNA polymerase activity//zinc ion binding//chromatin binding GO:0000785//GO:0005634//GO:0042575//GO:0000775 chromatin//nucleus//DNA polymerase complex//chromosome, centromeric region -- -- Cluster-8309.48595 BF_2 242.56 8.88 1430 642934319 XP_008198599.1 370 1.2e-32 PREDICTED: inositol hexakisphosphate kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48598 BF_2 133.91 4.33 1580 91079782 XP_967732.1 1056 3.6e-112 PREDICTED: 39S ribosomal protein L38, mitochondrial [Tribolium castaneum]>gi|270003311|gb|EEZ99758.1| hypothetical protein TcasGA2_TC002530 [Tribolium castaneum] 170048742 XM_001870724.1 53 2.44119e-16 Culex quinquefasciatus mitochondrial ribosomal protein L38, mRNA K17419 MRPL38 large subunit ribosomal protein L38 http://www.genome.jp/dbget-bin/www_bget?ko:K17419 Q3ZBF3 690 4.1e-71 39S ribosomal protein L38, mitochondrial OS=Bos taurus GN=MRPL38 PE=1 SV=2 PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.48600 BF_2 40.88 0.73 2625 642934689 XP_972767.2 2951 0.0e+00 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 D3ZGS3 1477 3.8e-162 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Rattus norvegicus GN=Ocrl PE=1 SV=1 PF16276//PF00620//PF01113 Nucleophosmin C-terminal domain//RhoGAP domain//Dihydrodipicolinate reductase, N-terminus GO:0009089//GO:0007165//GO:0055114//GO:0009085 lysine biosynthetic process via diaminopimelate//signal transduction//oxidation-reduction process//lysine biosynthetic process GO:0008839//GO:0003676 4-hydroxy-tetrahydrodipicolinate reductase//nucleic acid binding -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.48602 BF_2 7.26 0.42 1002 642934689 XP_972767.2 841 2.0e-87 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 D3ZGS3 410 7.7e-39 Inositol polyphosphate 5-phosphatase OCRL-1 OS=Rattus norvegicus GN=Ocrl PE=1 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.48604 BF_2 23.00 1.10 1158 642934689 XP_972767.2 367 2.1e-32 PREDICTED: inositol polyphosphate 5-phosphatase OCRL-1 [Tribolium castaneum] -- -- -- -- -- K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 Q8K337 141 1.4e-07 Type II inositol 1,4,5-trisphosphate 5-phosphatase OS=Mus musculus GN=Inpp5b PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48605 BF_2 28.00 0.41 3124 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48606 BF_2 535.47 2.90 8000 642932579 XP_008196910.1 4322 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 11 homolog [Tribolium castaneum] 642932706 XM_008198731.1 204 1.44225e-99 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 45 (LOC655219), mRNA -- -- -- -- Q9H270 1966 2.3e-218 Vacuolar protein sorting-associated protein 11 homolog OS=Homo sapiens GN=VPS11 PE=1 SV=1 PF13639//PF01165//PF00637//PF12861//PF00443//PF00569//PF02723//PF12678//PF02148//PF14634//PF00097//PF17122 Ring finger domain//Ribosomal protein S21//Region in Clathrin and VPS//Anaphase-promoting complex subunit 11 RING-H2 finger//Ubiquitin carboxyl-terminal hydrolase//Zinc finger, ZZ type//Non-structural protein NS3/Small envelope protein E//RING-H2 zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Zinc-finger GO:0016567//GO:0016192//GO:0006886//GO:0006412//GO:0042254//GO:0016579 protein ubiquitination//vesicle-mediated transport//intracellular protein transport//translation//ribosome biogenesis//protein deubiquitination GO:0004842//GO:0005515//GO:0036459//GO:0046872//GO:0008270//GO:0003735 ubiquitin-protein transferase activity//protein binding//ubiquitinyl hydrolase activity//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005680//GO:0005840//GO:0016020 anaphase-promoting complex//ribosome//membrane KOG2114 Vacuolar assembly/sorting protein PEP5/VPS11 Cluster-8309.48610 BF_2 68.00 4.46 925 270013391 EFA09839.1 1338 4.3e-145 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 35 1.42834e-06 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P07207 158 1.2e-09 Neurogenic locus Notch protein OS=Drosophila melanogaster GN=N PE=1 SV=3 PF00203 Ribosomal protein S19 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.48612 BF_2 309.90 1.54 8680 478262858 ENN81340.1 3676 0.0e+00 hypothetical protein YQE_02251, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VFB7 1853 3.1e-205 Trafficking protein particle complex subunit 10 OS=Drosophila melanogaster GN=SIDL PE=1 SV=1 PF01484 Nematode cuticle collagen N-terminal domain -- -- GO:0042302 structural constituent of cuticle -- -- KOG1931 Putative transmembrane protein Cluster-8309.48613 BF_2 55.79 3.55 945 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48616 BF_2 85.00 6.24 857 94468538 ABF18118.1 178 1.3e-10 TIL domain-containing cysteine-rich salivary secreted peptide [Aedes aegypti] -- -- -- -- -- -- -- -- -- P0DM55 131 1.5e-06 Venom peptide SjAPI OS=Scorpiops jendeki PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48617 BF_2 6.28 0.35 1045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48619 BF_2 164.58 3.26 2400 642923613 XP_008193578.1 1827 2.2e-201 PREDICTED: major facilitator superfamily domain-containing protein 1 isoform X2 [Tribolium castaneum] 817183853 XM_012423204.1 72 1.02438e-26 PREDICTED: Orussus abietinus major facilitator superfamily domain-containing protein 1 (LOC105698724), mRNA -- -- -- -- Q32LQ6 1323 2.5e-144 Major facilitator superfamily domain-containing protein 1 OS=Danio rerio GN=mfsd1 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG4686 Predicted sugar transporter Cluster-8309.4862 BF_2 3.00 2.73 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48626 BF_2 135.44 3.19 2062 270012761 EFA09209.1 2062 1.1e-228 Eph receptor tyrosine kinase [Tribolium castaneum] 642930930 XM_008197924.1 296 2.64589e-151 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P28693 779 2.6e-81 Ephrin type-B receptor 2 OS=Gallus gallus GN=EPHB2 PE=1 SV=3 PF02544//PF01404//PF00041//PF16656 3-oxo-5-alpha-steroid 4-dehydrogenase//Ephrin receptor ligand binding domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006629//GO:0006771//GO:0048013 hexachlorocyclohexane metabolic process//lipid metabolic process//riboflavin metabolic process//ephrin receptor signaling pathway GO:0005515//GO:0003993//GO:0046872//GO:0016627 protein binding//acid phosphatase activity//metal ion binding//oxidoreductase activity, acting on the CH-CH group of donors GO:0016021//GO:0005737 integral component of membrane//cytoplasm -- -- Cluster-8309.48627 BF_2 107.40 4.10 1383 642929791 XP_008195979.1 859 2.2e-89 PREDICTED: oxysterol-binding protein-related protein 9 isoform X2 [Tribolium castaneum] 755507583 XM_006502619.2 92 4.45023e-38 PREDICTED: Mus musculus oxysterol binding protein-like 9 (Osbpl9), transcript variant X3, mRNA -- -- -- -- Q96SU4 629 4.3e-64 Oxysterol-binding protein-related protein 9 OS=Homo sapiens GN=OSBPL9 PE=1 SV=2 PF06667//PF03510 Phage shock protein B//2C endopeptidase (C24) cysteine protease family GO:0009271//GO:0006508//GO:0006355 phage shock//proteolysis//regulation of transcription, DNA-templated GO:0004197 cysteine-type endopeptidase activity -- -- KOG2210 Oxysterol-binding protein Cluster-8309.48628 BF_2 98.38 1.98 2370 665820747 XP_008559286.1 1602 2.7e-175 PREDICTED: guanine nucleotide-binding protein subunit beta-5 [Microplitis demolitor] 807025222 XM_004523529.2 192 1.98283e-93 PREDICTED: Ceratitis capitata guanine nucleotide-binding protein subunit beta-5 (LOC101456443), mRNA K04539 GNB5 guanine nucleotide-binding protein subunit beta-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04539 Q6PNB6 1309 1.0e-142 Guanine nucleotide-binding protein subunit beta-5 OS=Oryctolagus cuniculus GN=GNB5 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.48629 BF_2 417.35 3.52 5246 642912602 XP_008200928.1 1201 1.9e-128 PREDICTED: poly(A) RNA polymerase gld-2 homolog A-like [Tribolium castaneum]>gi|270002400|gb|EEZ98847.1| hypothetical protein TcasGA2_TC004457 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW4 846 1.1e-88 ER membrane protein complex subunit 3 OS=Danio rerio GN=emc3 PE=2 SV=1 PF01956//PF06596//PF01909 Integral membrane protein DUF106//Photosystem II reaction centre X protein (PsbX)//Nucleotidyltransferase domain GO:0015979 photosynthesis GO:0016779 nucleotidyltransferase activity GO:0009523//GO:0016020 photosystem II//membrane KOG3188 Uncharacterized conserved protein Cluster-8309.48633 BF_2 82.30 1.96 2046 270001314 EEZ97761.1 2240 2.4e-249 hect domain and RLD 2-like protein [Tribolium castaneum] 642937613 XM_008200900.1 321 3.32435e-165 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase HERC2 (LOC656972), mRNA K10595 HERC2 E3 ubiquitin-protein ligase HERC2 http://www.genome.jp/dbget-bin/www_bget?ko:K10595 Q4U2R1 1668 2.1e-184 E3 ubiquitin-protein ligase HERC2 OS=Mus musculus GN=Herc2 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.48634 BF_2 58.52 1.14 2434 642922794 XP_008193328.1 1279 7.8e-138 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 723 9.5e-75 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48637 BF_2 5.00 2.25 378 211939884 ACJ13424.1 159 9.0e-09 serpin [Sphenophorus levis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48640 BF_2 82.53 3.48 1280 91089043 XP_969794.1 1019 5.8e-108 PREDICTED: regulatory-associated protein of mTOR isoform X1 [Tribolium castaneum]>gi|270012399|gb|EFA08847.1| hypothetical protein TcasGA2_TC006548 [Tribolium castaneum] -- -- -- -- -- K07204 RAPTOR regulatory associated protein of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K07204 Q8K4Q0 554 2.0e-55 Regulatory-associated protein of mTOR OS=Mus musculus GN=Rptor PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1517 Guanine nucleotide binding protein MIP1 Cluster-8309.48649 BF_2 840.61 12.71 3054 642932587 XP_967273.3 1369 3.6e-148 PREDICTED: S-adenosylmethionine decarboxylase proenzyme isoform X2 [Tribolium castaneum]>gi|270011546|gb|EFA07994.1| hypothetical protein TcasGA2_TC005583 [Tribolium castaneum] -- -- -- -- -- K01611 speD, AMD1 S-adenosylmethionine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01611 P91931 873 4.8e-92 S-adenosylmethionine decarboxylase proenzyme OS=Drosophila melanogaster GN=SamDC PE=2 SV=1 PF01536 Adenosylmethionine decarboxylase GO:0006597//GO:0008295//GO:0006560//GO:0006557//GO:0006525 spermine biosynthetic process//spermidine biosynthetic process//proline metabolic process//S-adenosylmethioninamine biosynthetic process//arginine metabolic process GO:0004014 adenosylmethionine decarboxylase activity -- -- KOG0788 S-adenosylmethionine decarboxylase Cluster-8309.4865 BF_2 7.00 1.76 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48651 BF_2 9.61 0.38 1352 91083703 XP_969630.1 380 7.6e-34 PREDICTED: monocarboxylate transporter 5 [Tribolium castaneum]>gi|270007880|gb|EFA04328.1| hypothetical protein TcasGA2_TC014622 [Tribolium castaneum] -- -- -- -- -- K11810 SLC16A12 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11810 Q6ZSM3 161 7.7e-10 Monocarboxylate transporter 12 OS=Homo sapiens GN=SLC16A12 PE=1 SV=2 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.48653 BF_2 43.00 43.43 318 -- -- -- -- -- 642927790 XM_965363.2 50 2.09644e-15 PREDICTED: Tribolium castaneum nucleolysin TIAR (LOC659024), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48654 BF_2 55.00 0.80 3151 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48655 BF_2 168.96 2.59 3019 91079606 XP_966371.1 1455 3.8e-158 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|642917676|ref|XP_008191323.1| PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270003388|gb|EEZ99835.1| hypothetical protein TcasGA2_TC002616 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 585 1.2e-58 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 PF01312 FlhB HrpN YscU SpaS Family GO:0009306 protein secretion -- -- GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.48659 BF_2 20.62 0.70 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4866 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48665 BF_2 819.13 67.08 798 642920923 XP_008192617.1 821 3.3e-85 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q6GMC7 450 1.4e-43 Alcohol dehydrogenase [NADP(+)] OS=Xenopus laevis GN=akr1a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.48666 BF_2 8.98 0.58 935 642920923 XP_008192617.1 796 3.0e-82 PREDICTED: aldose reductase isoform X2 [Tribolium castaneum] -- -- -- -- -- K00002 AKR1A1, adh alcohol dehydrogenase (NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00002 Q6GMC7 450 1.6e-43 Alcohol dehydrogenase [NADP(+)] OS=Xenopus laevis GN=akr1a1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.48669 BF_2 124.01 1.00 5481 642925021 XP_008194139.1 3705 0.0e+00 PREDICTED: amyloid beta A4 precursor protein-binding family B member 1-interacting protein-like isoform X3 [Tribolium castaneum] 462328174 APGK01040787.1 46 6.69597e-12 Dendroctonus ponderosae Seq01040797, whole genome shotgun sequence K17704 APBB1IP, RIAM amyloid beta A4 precursor protein-binding family B member 1-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K17704 Q70E73 728 5.6e-75 Ras-associated and pleckstrin homology domains-containing protein 1 OS=Homo sapiens GN=RAPH1 PE=1 SV=3 PF00788 Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction -- -- -- -- KOG3751 Growth factor receptor-bound proteins (GRB7, GRB10, GRB14) Cluster-8309.48671 BF_2 18.20 0.63 1503 91088445 XP_968690.1 775 1.3e-79 PREDICTED: E3 ubiquitin-protein ligase CHIP [Tribolium castaneum]>gi|270012210|gb|EFA08658.1| hypothetical protein TcasGA2_TC006323 [Tribolium castaneum] -- -- -- -- -- K09561 STUB1, CHIP STIP1 homology and U-box containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09561 Q9UNE7 457 4.1e-44 E3 ubiquitin-protein ligase CHIP OS=Homo sapiens GN=STUB1 PE=1 SV=2 PF13181//PF13174//PF13371//PF07497//PF00515//PF04658//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Rho termination factor, RNA-binding domain//Tetratricopeptide repeat//TAFII55 protein conserved region//Tetratricopeptide repeat//TPR repeat GO:0006353//GO:0006367//GO:0016567 DNA-templated transcription, termination//transcription initiation from RNA polymerase II promoter//protein ubiquitination GO:0003723//GO:0005515//GO:0004842 RNA binding//protein binding//ubiquitin-protein transferase activity GO:0005669//GO:0000151 transcription factor TFIID complex//ubiquitin ligase complex KOG4642 Chaperone-dependent E3 ubiquitin protein ligase (contains TPR repeats) Cluster-8309.48675 BF_2 594.37 26.97 1209 478263332 ENN81711.1 185 2.8e-11 hypothetical protein YQE_01916, partial [Dendroctonus ponderosae]>gi|546681318|gb|ERL91432.1| hypothetical protein D910_08762 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48676 BF_2 159.00 12.60 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48678 BF_2 90.47 1.39 3005 642918691 XP_008191539.1 1571 1.3e-171 PREDICTED: protein sprint isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 643 2.2e-65 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.48680 BF_2 543.69 9.20 2760 642926591 XP_008194932.1 1964 3.3e-217 PREDICTED: scavenger receptor class B member 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WTV0 538 3.0e-53 Scavenger receptor class B member 1 OS=Homo sapiens GN=SCARB1 PE=1 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.48681 BF_2 100.11 3.23 1582 642923174 XP_008193640.1 552 1.0e-53 PREDICTED: kinesin-like protein subito isoform X1 [Tribolium castaneum] -- -- -- -- -- K10402 KIF20 kinesin family member 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10402 Q9V877 354 3.8e-32 Kinesin-like protein subito OS=Drosophila melanogaster GN=sub PE=1 SV=1 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0247 Kinesin-like protein Cluster-8309.48682 BF_2 123.97 5.31 1264 642915518 XP_968660.2 732 1.1e-74 PREDICTED: syntaxin-8 [Tribolium castaneum] -- -- -- -- -- K08501 STX8 syntaxin 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08501 Q3T075 258 4.1e-21 Syntaxin-8 OS=Bos taurus GN=STX8 PE=2 SV=1 PF11744//PF05739//PF06009 Aluminium activated malate transporter//SNARE domain//Laminin Domain II GO:0015743//GO:0007155 malate transport//cell adhesion GO:0005515 protein binding -- -- KOG3202 SNARE protein TLG1/Syntaxin 6 Cluster-8309.48683 BF_2 15.13 0.37 2011 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48685 BF_2 277.09 5.28 2482 642920515 XP_008192382.1 1349 6.0e-146 PREDICTED: TWiK family of potassium channels protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34410 335 9.5e-30 TWiK family of potassium channels protein 7 OS=Caenorhabditis elegans GN=twk-7 PE=3 SV=3 PF07830//PF00520//PF01007 Protein serine/threonine phosphatase 2C, C-terminal domain//Ion transport protein//Inward rectifier potassium channel GO:0006811//GO:0055085//GO:0006813//GO:0006470 ion transport//transmembrane transport//potassium ion transport//protein dephosphorylation GO:0005216//GO:0000287//GO:0004721//GO:0005242//GO:0030145 ion channel activity//magnesium ion binding//phosphoprotein phosphatase activity//inward rectifier potassium channel activity//manganese ion binding GO:0016020//GO:0008076//GO:0016021 membrane//voltage-gated potassium channel complex//integral component of membrane KOG1418 Tandem pore domain K+ channel Cluster-8309.48686 BF_2 8.17 0.48 1004 270009422 EFA05870.1 306 2.1e-25 hypothetical protein TcasGA2_TC008670 [Tribolium castaneum] -- -- -- -- -- K10904 TIPIN TIMELESS-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K10904 Q0IHI4 216 2.4e-16 TIMELESS-interacting protein OS=Xenopus laevis GN=tipin PE=1 SV=1 PF07962 Replication Fork Protection Component Swi3 GO:0006974//GO:0007049//GO:0048478 cellular response to DNA damage stimulus//cell cycle//replication fork protection -- -- GO:0005634 nucleus KOG3004 Meiotic chromosome segregation protein Cluster-8309.48687 BF_2 25.69 0.63 1983 642928356 XP_008195548.1 966 1.2e-101 PREDICTED: abhydrolase domain-containing protein 4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K13699 ABHD5, CGI-58 abhydrolase domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13699 Q9DBL9 560 6.1e-56 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Mus musculus GN=Abhd5 PE=1 SV=1 PF16929//PF01764//PF07819//PF02230//PF07859//PF03403 Accessory Sec system GspB-transporter//Lipase (class 3)//PGAP1-like protein//Phospholipase/Carboxylesterase//alpha/beta hydrolase fold//Platelet-activating factor acetylhydrolase, isoform II GO:0006505//GO:0008152//GO:0006886//GO:0006629//GO:0016042//GO:0015031//GO:0046486 GPI anchor metabolic process//metabolic process//intracellular protein transport//lipid metabolic process//lipid catabolic process//protein transport//glycerolipid metabolic process GO:0016788//GO:0003847//GO:0016787 hydrolase activity, acting on ester bonds//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.48688 BF_2 255.90 5.75 2148 270010344 EFA06792.1 1271 5.8e-137 hypothetical protein TcasGA2_TC009729 [Tribolium castaneum] -- -- -- -- -- K13699 ABHD5, CGI-58 abhydrolase domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13699 Q8WTS1 771 2.3e-80 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 OS=Homo sapiens GN=ABHD5 PE=1 SV=1 PF07819//PF03403 PGAP1-like protein//Platelet-activating factor acetylhydrolase, isoform II GO:0006886//GO:0046486//GO:0016042//GO:0006505 intracellular protein transport//glycerolipid metabolic process//lipid catabolic process//GPI anchor metabolic process GO:0003847//GO:0016788 1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4409 Predicted hydrolase/acyltransferase (alpha/beta hydrolase superfamily) Cluster-8309.48690 BF_2 1.00 0.44 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48695 BF_2 517.06 14.10 1821 546673062 ERL84739.1 984 9.4e-104 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 453 1.4e-43 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF02230//PF10503//PF01764//PF03583 Phospholipase/Carboxylesterase//Esterase PHB depolymerase//Lipase (class 3)//Secretory lipase GO:0046486//GO:0006629//GO:0016042 glycerolipid metabolic process//lipid metabolic process//lipid catabolic process GO:0004806//GO:0016787 triglyceride lipase activity//hydrolase activity GO:0005576 extracellular region KOG1552 Predicted alpha/beta hydrolase Cluster-8309.48697 BF_2 98.36 0.74 5818 642937199 XP_008198736.1 4828 0.0e+00 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 5.41945e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1968 9.8e-219 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00787//PF00168//PF00454 PX domain//C2 domain//Phosphatidylinositol 3- and 4-kinase -- -- GO:0016773//GO:0035091//GO:0005515 phosphotransferase activity, alcohol group as acceptor//phosphatidylinositol binding//protein binding -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.48701 BF_2 204.86 2.17 4242 642931487 XP_008196606.1 1648 2.2e-180 PREDICTED: insulin receptor substrate 1 isoform X10 [Tribolium castaneum] -- -- -- -- -- K16172 IRS1 insulin receptor substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K16172 B4NZ70 563 5.9e-56 Insulin receptor substrate 1 OS=Drosophila yakuba GN=chico PE=3 SV=1 PF02174 PTB domain (IRS-1 type) GO:0007165 signal transduction GO:0005158 insulin receptor binding GO:0005899 insulin receptor complex -- -- Cluster-8309.48703 BF_2 422.06 15.13 1454 270013585 EFA10033.1 947 1.5e-99 hypothetical protein TcasGA2_TC012205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N3F8 294 3.1e-25 MICAL-like protein 1 OS=Homo sapiens GN=MICALL1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48706 BF_2 173.77 5.15 1700 332376807 AEE63543.1 1800 2.1e-198 unknown [Dendroctonus ponderosae] 645003053 XM_008209892.1 41 1.23268e-09 PREDICTED: Nasonia vitripennis kynurenine--oxoglutarate transaminase 3-like (LOC100119206), mRNA K00816 CCBL kynurenine---oxoglutarate transaminase / cysteine-S-conjugate beta-lyase / glutamine---phenylpyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00816 Q6YP21 1245 2.0e-135 Kynurenine--oxoglutarate transaminase 3 OS=Homo sapiens GN=CCBL2 PE=1 SV=1 PF00155//PF01053 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG0257 Kynurenine aminotransferase, glutamine transaminase K Cluster-8309.48707 BF_2 129.00 2.73 2263 91088777 XP_967353.1 2052 1.7e-227 PREDICTED: protein phosphatase 1 regulatory subunit 16A [Tribolium castaneum]>gi|270011631|gb|EFA08079.1| hypothetical protein TcasGA2_TC005675 [Tribolium castaneum] -- -- -- -- -- K17458 PPP1R16A, MYPT3 protein phosphatase 1 regulatory subunit 16A http://www.genome.jp/dbget-bin/www_bget?ko:K17458 Q95N27 945 1.6e-100 Protein phosphatase 1 regulatory inhibitor subunit 16B OS=Bos taurus GN=PPP1R16B PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.48709 BF_2 14.00 0.46 1568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48711 BF_2 27.39 0.44 2909 546680360 ERL90639.1 3369 0.0e+00 hypothetical protein D910_07986 [Dendroctonus ponderosae] 759040950 XM_011330978.1 45 1.27071e-11 PREDICTED: Cerapachys biroi UPF0378 protein KIAA0100 (LOC105274669), transcript variant X2, mRNA -- -- -- -- Q5SYL3 1379 9.7e-151 Protein KIAA0100 OS=Mus musculus GN=Kiaa0100 PE=2 SV=1 PF02601 Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG1910 Uncharacterized conserved protein Cluster-8309.48715 BF_2 89.79 0.92 4350 91093869 XP_967782.1 6281 0.0e+00 PREDICTED: cytoplasmic FMR1-interacting protein [Tribolium castaneum]>gi|270014526|gb|EFA10974.1| hypothetical protein TcasGA2_TC004140 [Tribolium castaneum] 572271770 XM_006613756.1 995 0 PREDICTED: Apis dorsata cytoplasmic FMR1-interacting protein-like (LOC102675501), mRNA K05749 CYFIP cytoplasmic FMR1 interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K05749 Q9VF87 5547 0.0e+00 Cytoplasmic FMR1-interacting protein OS=Drosophila melanogaster GN=Sra-1 PE=1 SV=1 -- -- -- -- -- -- GO:0005737 cytoplasm KOG3534 p53 inducible protein PIR121 Cluster-8309.48716 BF_2 11.00 0.35 1588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48718 BF_2 305.34 3.72 3718 189239090 XP_968540.2 1587 2.3e-173 PREDICTED: cystathionine beta-synthase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01697 E4.2.1.22, CBS cystathionine beta-synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01697 P35520 1187 2.3e-128 Cystathionine beta-synthase OS=Homo sapiens GN=CBS PE=1 SV=2 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- KOG1252 Cystathionine beta-synthase and related enzymes Cluster-8309.48724 BF_2 1259.61 15.36 3718 478260883 ENN80520.1 656 2.1e-65 hypothetical protein YQE_03059, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IZR5 180 1.3e-11 CKLF-like MARVEL transmembrane domain-containing protein 4 OS=Homo sapiens GN=CMTM4 PE=1 SV=1 PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane KOG4788 Members of chemokine-like factor super family and related proteins Cluster-8309.48727 BF_2 125.65 1.63 3514 91090862 XP_972769.1 1643 6.9e-180 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 132 6.6682e-60 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 Q92905 1371 9.9e-150 COP9 signalosome complex subunit 5 OS=Homo sapiens GN=COPS5 PE=1 SV=4 PF11890//PF03083//PF01040//PF01398 Domain of unknown function (DUF3410)//Sugar efflux transporter for intercellular exchange//UbiA prenyltransferase family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0046983//GO:0005515//GO:0004659 protein dimerization activity//protein binding//prenyltransferase activity GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.48728 BF_2 100.25 1.28 3573 91090862 XP_972769.1 1643 7.1e-180 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 132 6.78132e-60 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 O35864 1371 1.0e-149 COP9 signalosome complex subunit 5 OS=Mus musculus GN=Cops5 PE=1 SV=3 PF03083//PF01040//PF01398 Sugar efflux transporter for intercellular exchange//UbiA prenyltransferase family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0004659//GO:0005515 prenyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.48731 BF_2 372.04 3.72 4474 478255758 ENN75967.1 1670 6.5e-183 hypothetical protein YQE_07501, partial [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 P57094 335 1.7e-29 Axin-1 OS=Danio rerio GN=axin1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48732 BF_2 1.00 36.54 204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48735 BF_2 100.18 0.73 6014 478260301 ENN80053.1 2656 4.1e-297 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1477 8.7e-162 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF04851//PF04408//PF02562//PF00437//PF07652//PF00270 Type III restriction enzyme, res subunit//Helicase associated domain (HA2)//PhoH-like protein//Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0019079//GO:0006810 viral genome replication//transport GO:0016787//GO:0003677//GO:0004386//GO:0005524//GO:0008026//GO:0003676 hydrolase activity//DNA binding//helicase activity//ATP binding//ATP-dependent helicase activity//nucleic acid binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.48736 BF_2 141.94 1.21 5176 478260301 ENN80053.1 3354 0.0e+00 hypothetical protein YQE_03529, partial [Dendroctonus ponderosae] -- -- -- -- -- K18408 TDRD9 ATP-dependent RNA helicase TDRD9 http://www.genome.jp/dbget-bin/www_bget?ko:K18408 B0XDC4 1901 5.1e-211 Probable ATP-dependent RNA helicase spindle-E OS=Culex quinquefasciatus GN=spn-E PE=3 SV=1 PF12189//PF04408//PF02562//PF04851//PF00437//PF07652//PF00270 Single-strand DNA-binding protein//Helicase associated domain (HA2)//PhoH-like protein//Type III restriction enzyme, res subunit//Type II/IV secretion system protein//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0006810//GO:0006457//GO:0019079//GO:0009405 transport//protein folding//viral genome replication//pathogenesis GO:0003676//GO:0005515//GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0004386 nucleic acid binding//protein binding//ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//helicase activity -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.48739 BF_2 27.67 1.32 1166 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48740 BF_2 31.07 0.51 2833 189237332 XP_973384.2 1523 4.6e-166 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 9.42901e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.4e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.48741 BF_2 67.03 1.15 2727 189237332 XP_973384.2 1500 2.1e-163 PREDICTED: transcription factor Dp-1 [Tribolium castaneum] 829770480 XM_012765543.1 65 9.07167e-23 PREDICTED: Microcebus murinus transcription factor Dp-1 (TFDP1), transcript variant X6, mRNA K04683 TFDP1 transcription factor Dp-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04683 Q08639 815 2.3e-85 Transcription factor Dp-1 OS=Mus musculus GN=Tfdp1 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2829 E2F-like protein Cluster-8309.48746 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48748 BF_2 34.46 0.40 3923 270016526 EFA12972.1 942 1.5e-98 hypothetical protein TcasGA2_TC010996 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 561 9.3e-56 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 PF09198 Bacteriophage T4 beta-glucosyltransferase GO:0006304 DNA modification GO:0033821 DNA beta-glucosyltransferase activity -- -- KOG3097 Predicted membrane protein Cluster-8309.4875 BF_2 6.96 0.83 640 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48751 BF_2 676.65 8.07 3796 642930270 XP_008196324.1 1192 1.5e-127 PREDICTED: uncharacterized protein LOC103313834 [Tribolium castaneum] 642930269 XM_008198102.1 181 4.15831e-87 PREDICTED: Tribolium castaneum uncharacterized LOC103313834 (LOC103313834), mRNA -- -- -- -- -- -- -- -- PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.48752 BF_2 2.00 0.38 509 546673958 ERL85466.1 195 8.1e-13 hypothetical protein D910_02885 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVH3 123 7.4e-06 MICOS complex subunit MIC13 homolog OS=Drosophila melanogaster GN=CG7603 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48753 BF_2 357.00 24.33 901 546673958 ERL85466.1 303 4.3e-25 hypothetical protein D910_02885 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVH3 166 1.4e-10 MICOS complex subunit MIC13 homolog OS=Drosophila melanogaster GN=CG7603 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48757 BF_2 53.25 0.64 3744 91094203 XP_971608.1 1093 4.4e-116 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.85702e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 668 3.5e-68 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.48760 BF_2 63.52 0.99 2962 189237054 XP_966641.2 758 2.4e-77 PREDICTED: bcl-2-related ovarian killer protein [Tribolium castaneum]>gi|270007277|gb|EFA03725.1| hypothetical protein TcasGA2_TC013830 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I8I2 201 3.9e-14 Bcl-2-related ovarian killer protein OS=Gallus gallus GN=BOK PE=2 SV=1 PF00452//PF14489 Apoptosis regulator proteins, Bcl-2 family//QueF-like protein GO:0042981//GO:0008616 regulation of apoptotic process//queuosine biosynthetic process GO:0033739 preQ1 synthase activity -- -- -- -- Cluster-8309.48762 BF_2 321.87 2.71 5251 642934118 XP_008199283.1 1895 6.2e-209 PREDICTED: high affinity cationic amino acid transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 P30825 1299 3.3e-141 High affinity cationic amino acid transporter 1 OS=Homo sapiens GN=SLC7A1 PE=1 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.48763 BF_2 19.77 0.37 2534 642911681 XP_008200699.1 1856 1.0e-204 PREDICTED: stAR-related lipid transfer protein 13 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q923Q2 1063 3.7e-114 StAR-related lipid transfer protein 13 OS=Mus musculus GN=Stard13 PE=1 SV=5 PF01852//PF00620 START domain//RhoGAP domain GO:0007165 signal transduction GO:0008289 lipid binding -- -- KOG2200 Tumour suppressor protein p122-RhoGAP/DLC1 Cluster-8309.48766 BF_2 423.35 5.69 3398 642923323 XP_001814851.2 2046 1.2e-226 PREDICTED: transport and Golgi organization protein 6 [Tribolium castaneum]>gi|270007618|gb|EFA04066.1| hypothetical protein TcasGA2_TC014300 [Tribolium castaneum] 501297508 AK417956.1 98 5.12593e-41 Riptortus pedestris mRNA for NEDD8, putative, complete cds, sequence id: Rped-1360 -- -- -- -- P61282 288 3.7e-24 NEDD8 OS=Bos taurus GN=NEDD8 PE=3 SV=1 PF13443//PF00452//PF00240//PF02985//PF14560 Cro/C1-type HTH DNA-binding domain//Apoptosis regulator proteins, Bcl-2 family//Ubiquitin family//HEAT repeat//Ubiquitin-like domain GO:0042981 regulation of apoptotic process GO:0043565//GO:0005515 sequence-specific DNA binding//protein binding -- -- KOG0005 Ubiquitin-like protein Cluster-8309.48767 BF_2 3.17 0.52 541 478260658 ENN80355.1 495 1.4e-47 hypothetical protein YQE_03214, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q25519 430 2.0e-41 Phenoloxidase subunit 2 OS=Manduca sexta GN=ppo PE=1 SV=3 PF03490 Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.48769 BF_2 20.00 1.90 727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4877 BF_2 6.00 0.34 1015 642919293 XP_008191813.1 951 3.5e-100 PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum]>gi|642919295|ref|XP_008191814.1| PREDICTED: transmembrane and TPR repeat-containing protein CG4341-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V3X5 555 1.2e-55 Transmembrane and TPR repeat-containing protein CG4341 OS=Drosophila melanogaster GN=CG4341 PE=2 SV=1 PF13371//PF13374//PF13181//PF00515//PF13414//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.48773 BF_2 175.32 4.97 1763 642912303 XP_008200641.1 1230 2.7e-132 PREDICTED: protein couch potato isoform X3 [Tribolium castaneum] 642912304 XM_008202420.1 321 2.85652e-165 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X4, mRNA -- -- -- -- Q01617 713 9.9e-74 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00076//PF17051 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Cytochrome C oxidase assembly factor 2 GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0003676 nucleic acid binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.48774 BF_2 28.51 0.41 3162 642934087 XP_008196609.1 1036 1.5e-109 PREDICTED: phosphatase and actin regulator 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.4e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF04904//PF00344//PF00957 NAB conserved region 1 (NCD1)//SecY translocase//Synaptobrevin GO:0045892//GO:0016192//GO:0015031 negative regulation of transcription, DNA-templated//vesicle-mediated transport//protein transport -- -- GO:0005634//GO:0016021//GO:0016020 nucleus//integral component of membrane//membrane KOG4339 RPEL repeat-containing protein Cluster-8309.48776 BF_2 332.74 6.01 2604 478253945 ENN74237.1 863 1.4e-89 hypothetical protein YQE_09210, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BJM3 303 5.1e-26 Coiled-coil domain-containing protein R3HCC1L OS=Mus musculus GN=R3hcc1l PE=2 SV=1 PF08675 RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0046872//GO:0003723//GO:0004535 metal ion binding//RNA binding//poly(A)-specific ribonuclease activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG4483 Uncharacterized conserved protein Cluster-8309.48777 BF_2 10.00 1.27 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48778 BF_2 847.43 7.40 5080 642933029 XP_008197236.1 2620 5.2e-293 PREDICTED: putative polypeptide N-acetylgalactosaminyltransferase 9 isoform X2 [Tribolium castaneum] 642933028 XM_008199014.1 472 0 PREDICTED: Tribolium castaneum putative polypeptide N-acetylgalactosaminyltransferase 9 (LOC658959), transcript variant X2, mRNA K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MRC9 2103 1.9e-234 Putative polypeptide N-acetylgalactosaminyltransferase 9 OS=Drosophila melanogaster GN=pgant9 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.48780 BF_2 214.36 2.66 3654 642926488 XP_008191976.1 3661 0.0e+00 PREDICTED: probable ATP-dependent RNA helicase kurz [Tribolium castaneum]>gi|270009095|gb|EFA05543.1| hypothetical protein TcasGA2_TC015731 [Tribolium castaneum] -- -- -- -- -- K14780 DHX37, DHR1 ATP-dependent RNA helicase DHX37/DHR1 http://www.genome.jp/dbget-bin/www_bget?ko:K14780 O46072 2658 6.0e-299 Probable ATP-dependent RNA helicase kurz OS=Drosophila melanogaster GN=kz PE=1 SV=1 PF01580//PF00270//PF07652//PF04851//PF02562//PF02399//PF00437//PF04408 FtsK/SpoIIIE family//DEAD/DEAH box helicase//Flavivirus DEAD domain//Type III restriction enzyme, res subunit//PhoH-like protein//Origin of replication binding protein//Type II/IV secretion system protein//Helicase associated domain (HA2) GO:0019079//GO:0006810//GO:0006260 viral genome replication//transport//DNA replication GO:0005524//GO:0003688//GO:0004386//GO:0003677//GO:0016787//GO:0008026//GO:0000166//GO:0003676 ATP binding//DNA replication origin binding//helicase activity//DNA binding//hydrolase activity//ATP-dependent helicase activity//nucleotide binding//nucleic acid binding GO:0046809 replication compartment KOG0926 DEAH-box RNA helicase Cluster-8309.48781 BF_2 774.45 8.20 4236 91082383 XP_968748.1 3454 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2490 2.1e-279 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF02714//PF00004//PF00664//PF01926//PF13304//PF00931//PF01637//PF06414//PF02367//PF00005//PF03193 Calcium-dependent channel, 7TM region, putative phosphate//ATPase family associated with various cellular activities (AAA)//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//NB-ARC domain//Archaeal ATPase//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258 GO:0055085//GO:0006810//GO:0002949 transmembrane transport//transport//tRNA threonylcarbamoyladenosine modification GO:0005524//GO:0043531//GO:0003924//GO:0005525//GO:0016887//GO:0016301//GO:0042626//GO:0017111 ATP binding//ADP binding//GTPase activity//GTP binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//nucleoside-triphosphatase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.48782 BF_2 34.66 0.31 5019 642915929 XP_008190815.1 812 2.3e-83 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 400 5.6e-37 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.48783 BF_2 1328.19 13.90 4283 642926766 XP_008195005.1 4281 0.0e+00 PREDICTED: copper-transporting ATPase 1 isoform X1 [Tribolium castaneum] 827557043 XM_012694365.1 41 3.14328e-09 PREDICTED: Bombyx mori copper-transporting ATPase 2 (LOC101738315), transcript variant X5, mRNA K17686 copA, ATP7 Cu+-exporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K17686 Q64430 2523 3.2e-283 Copper-transporting ATPase 1 OS=Mus musculus GN=Atp7a PE=1 SV=3 PF00403//PF01529//PF00122//PF05138 Heavy-metal-associated domain//DHHC palmitoyltransferase//E1-E2 ATPase//Phenylacetic acid catabolic protein GO:0030001//GO:0010124 metal ion transport//phenylacetate catabolic process GO:0000166//GO:0008270//GO:0046872 nucleotide binding//zinc ion binding//metal ion binding -- -- KOG0207 Cation transport ATPase Cluster-8309.48784 BF_2 266.10 7.28 1816 478253376 ENN73730.1 320 9.2e-27 hypothetical protein YQE_09662, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5R7A8 165 3.6e-10 C-Myc-binding protein OS=Pongo abelii GN=MYCBP PE=3 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48785 BF_2 9.83 0.32 1565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48787 BF_2 1172.74 12.47 4220 642924110 XP_008194009.1 2553 2.5e-285 PREDICTED: serine/threonine-protein kinase mig-15 isoform X5 [Tribolium castaneum] 642924109 XM_008195787.1 939 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase mig-15 (LOC656940), transcript variant X5, mRNA K04413 MINK misshapen/NIK-related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04413 Q23356 1466 1.1e-160 Serine/threonine-protein kinase mig-15 OS=Caenorhabditis elegans GN=mig-15 PE=2 SV=3 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0587 Traf2- and Nck-interacting kinase and related germinal center kinase (GCK) family protein kinases Cluster-8309.48788 BF_2 81.25 1.16 3214 546679844 ERL90232.1 1075 4.6e-114 hypothetical protein D910_07585 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q0KIA2 553 6.5e-55 PP2C-like domain-containing protein CG9801 OS=Drosophila melanogaster GN=CG9801 PE=2 SV=1 PF07228 Stage II sporulation protein E (SpoIIE) -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.48794 BF_2 772.51 10.00 3519 478253702 ENN74001.1 1870 3.3e-206 hypothetical protein YQE_09391, partial [Dendroctonus ponderosae] 194741715 XM_001953298.1 46 4.28321e-12 Drosophila ananassae GF17255 (Dana\GF17255), mRNA K01942 HLCS biotin--protein ligase http://www.genome.jp/dbget-bin/www_bget?ko:K01942 Q920N2 610 1.7e-61 Biotin--protein ligase OS=Mus musculus GN=Hlcs PE=2 SV=1 PF02237//PF03099 Biotin protein ligase C terminal domain//Biotin/lipoate A/B protein ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG1536 Biotin holocarboxylase synthetase/biotin-protein ligase Cluster-8309.48796 BF_2 11.00 0.34 1658 642925318 XP_008194505.1 439 1.3e-40 PREDICTED: microtubule-associated proteins 1A/1B light chain 3C-like [Tribolium castaneum]>gi|270008734|gb|EFA05182.1| hypothetical protein TcasGA2_TC015312 [Tribolium castaneum] -- -- -- -- -- K10435 MAP1LC microtubule-associated protein 1 light chain http://www.genome.jp/dbget-bin/www_bget?ko:K10435 Q9BXW4 342 9.8e-31 Microtubule-associated proteins 1A/1B light chain 3C OS=Homo sapiens GN=MAP1LC3C PE=1 SV=1 PF02150//PF04110 RNA polymerases M/15 Kd subunit//Ubiquitin-like autophagy protein Apg12 GO:0000045//GO:0006144//GO:0006351//GO:0006206 autophagosome assembly//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005737 nucleolus//cytoplasm KOG1654 Microtubule-associated anchor protein involved in autophagy and membrane trafficking Cluster-8309.48799 BF_2 15.00 1.10 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48800 BF_2 277.96 1.04 11433 642920053 XP_008192184.1 2013 2.8e-222 PREDICTED: aarF domain-containing protein kinase 4 [Tribolium castaneum] 462387844 APGK01019785.1 56 3.86778e-17 Dendroctonus ponderosae Seq01019795, whole genome shotgun sequence K08869 ADCK, ABC1 aarF domain-containing kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08869 A3QJU3 1241 3.8e-134 AarF domain-containing protein kinase 4 OS=Danio rerio GN=adck4 PE=3 SV=2 PF08112//PF02297//PF13673//PF00159//PF03822//PF08159//PF13508//PF00583//PF08445 ATP synthase epsilon subunit//Cytochrome oxidase c subunit VIb//Acetyltransferase (GNAT) domain//Pancreatic hormone peptide//NAF domain//NUC153 domain//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein GO:0015986//GO:0015992//GO:0006123//GO:0007165//GO:0006810//GO:0042967 ATP synthesis coupled proton transport//proton transport//mitochondrial electron transport, cytochrome c to oxygen//signal transduction//transport//acyl-carrier-protein biosynthetic process GO:0016747//GO:0004129//GO:0008080//GO:0005179//GO:0042626 transferase activity, transferring acyl groups other than amino-acyl groups//cytochrome-c oxidase activity//N-acetyltransferase activity//hormone activity//ATPase activity, coupled to transmembrane movement of substances GO:0005576//GO:0005634//GO:0045277//GO:0005739//GO:0033178 extracellular region//nucleus//respiratory chain complex IV//mitochondrion//proton-transporting two-sector ATPase complex, catalytic domain KOG1234 ABC (ATP binding cassette) 1 protein Cluster-8309.48801 BF_2 450.85 2.20 8842 91093683 XP_970017.1 1672 7.6e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 2.4e-75 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01395//PF01553//PF04136//PF00115 PBP/GOBP family//Acyltransferase//Sec34-like family//Cytochrome C and Quinol oxidase polypeptide I GO:0008152//GO:0055114//GO:0015992//GO:0006118//GO:0006886//GO:0009060//GO:0006123 metabolic process//oxidation-reduction process//proton transport//obsolete electron transport//intracellular protein transport//aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0020037//GO:0009055//GO:0016746//GO:0005506//GO:0005549 cytochrome-c oxidase activity//heme binding//electron carrier activity//transferase activity, transferring acyl groups//iron ion binding//odorant binding GO:0016020//GO:0045277//GO:0005801//GO:0016021 membrane//respiratory chain complex IV//cis-Golgi network//integral component of membrane KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.48803 BF_2 10.70 0.67 958 642928025 XP_008200124.1 425 3.3e-39 PREDICTED: epidermal growth factor receptor substrate 15-like 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12472 EPS15 epidermal growth factor receptor substrate 15 http://www.genome.jp/dbget-bin/www_bget?ko:K12472 Q60902 149 1.4e-08 Epidermal growth factor receptor substrate 15-like 1 OS=Mus musculus GN=Eps15l1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48804 BF_2 42.79 0.35 5397 91078510 XP_969463.1 3442 0.0e+00 PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|642915541|ref|XP_008190658.1| PREDICTED: TATA element modulatory factor [Tribolium castaneum]>gi|270003849|gb|EFA00297.1| hypothetical protein TcasGA2_TC003130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82094 856 7.9e-90 TATA element modulatory factor OS=Homo sapiens GN=TMF1 PE=1 SV=2 PF03376 Adenovirus E3B protein -- -- -- -- GO:0016020 membrane KOG4673 Transcription factor TMF, TATA element modulatory factor Cluster-8309.48809 BF_2 37.48 12.57 411 546673559 ERL85134.1 167 1.2e-09 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48813 BF_2 3.00 0.31 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48814 BF_2 35.10 0.32 4808 642910690 XP_008200062.1 1046 1.6e-110 PREDICTED: serine protease snake [Tribolium castaneum]>gi|270015111|gb|EFA11559.1| serine protease P44 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 565 3.9e-56 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF01529//PF12422//PF00089 DHHC palmitoyltransferase//Condensin II non structural maintenance of chromosomes subunit//Trypsin GO:0006508 proteolysis GO:0008236//GO:0004252//GO:0008270 serine-type peptidase activity//serine-type endopeptidase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.48815 BF_2 684.04 14.54 2255 478263151 ENN81544.1 1606 8.7e-176 hypothetical protein YQE_02073, partial [Dendroctonus ponderosae] -- -- -- -- -- K18166 FOXRED1 FAD-dependent oxidoreductase domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18166 Q6DCP1 1055 2.8e-113 FAD-dependent oxidoreductase domain-containing protein 1 OS=Xenopus laevis GN=foxred1 PE=2 SV=1 PF01266//PF03435//PF05834//PF02558//PF00070//PF01494//PF07992//PF02254 FAD dependent oxidoreductase//Saccharopine dehydrogenase NADP binding domain//Lycopene cyclase protein//Ketopantoate reductase PanE/ApbA//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain GO:0015940//GO:0006813//GO:0016117//GO:0055114 pantothenate biosynthetic process//potassium ion transport//carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0071949//GO:0016491//GO:0008677 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oxidoreductase activity//2-dehydropantoate 2-reductase activity -- -- KOG2853 Possible oxidoreductase Cluster-8309.48816 BF_2 14.24 0.54 1385 91086693 XP_969563.1 484 6.8e-46 PREDICTED: 12 kDa FK506-binding protein [Tribolium castaneum]>gi|270010405|gb|EFA06853.1| hypothetical protein TcasGA2_TC009796 [Tribolium castaneum] -- -- -- -- -- K09568 FKBP1 FK506-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09568 P48375 429 6.6e-41 12 kDa FK506-binding protein OS=Drosophila melanogaster GN=FK506-bp2 PE=3 SV=2 PF01581 FMRFamide related peptide family GO:0000413//GO:0006457//GO:0007218 protein peptidyl-prolyl isomerization//protein folding//neuropeptide signaling pathway GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0544 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.48818 BF_2 8.00 0.31 1354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48819 BF_2 6.37 0.44 894 270006907 EFA03355.1 342 1.3e-29 hypothetical protein TcasGA2_TC013340 [Tribolium castaneum] -- -- -- -- -- K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 Q9XS79 192 1.3e-13 5-aminolevulinate synthase, nonspecific, mitochondrial OS=Delphinapterus leucas GN=ALAS1 PE=2 SV=1 PF09029 5-aminolevulinate synthase presequence GO:0006563//GO:0042967//GO:0006566//GO:0006778//GO:0006783//GO:0006544 L-serine metabolic process//acyl-carrier-protein biosynthetic process//threonine metabolic process//porphyrin-containing compound metabolic process//heme biosynthetic process//glycine metabolic process GO:0003870//GO:0030170 5-aminolevulinate synthase activity//pyridoxal phosphate binding GO:0005759 mitochondrial matrix KOG1360 5-aminolevulinate synthase Cluster-8309.48822 BF_2 406.76 2.09 8425 642934565 XP_008197717.1 3683 0.0e+00 PREDICTED: calponin homology domain-containing protein DDB_G0272472 isoform X1 [Tribolium castaneum]>gi|270013729|gb|EFA10177.1| hypothetical protein TcasGA2_TC012367 [Tribolium castaneum] -- -- -- -- -- K08800 NUAK NUAK family, SNF1-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08800 O60285 882 1.2e-92 NUAK family SNF1-like kinase 1 OS=Homo sapiens GN=NUAK1 PE=1 SV=1 PF06293//PF00069//PF07714//PF01533 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase//Tospovirus nucleocapsid protein GO:0006468 protein phosphorylation GO:0000166//GO:0005524//GO:0016773//GO:0004672 nucleotide binding//ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020//GO:0019013 membrane//viral nucleocapsid KOG0611 Predicted serine/threonine protein kinase Cluster-8309.48824 BF_2 75.16 1.10 3136 642910907 XP_008193460.1 1000 2.3e-105 PREDICTED: katanin p60 ATPase-containing subunit A-like 1 [Tribolium castaneum]>gi|642910909|ref|XP_008193461.1| PREDICTED: katanin p60 ATPase-containing subunit A-like 1 [Tribolium castaneum] 150013142 CP000743.1 37 3.83928e-07 Methanococcus aeolicus Nankai-3, complete genome K07767 KATNA1 katanin p60 ATPase-containing subunit A1 http://www.genome.jp/dbget-bin/www_bget?ko:K07767 Q9BW62 737 2.9e-76 Katanin p60 ATPase-containing subunit A-like 1 OS=Homo sapiens GN=KATNAL1 PE=1 SV=1 PF01695//PF07728//PF05496//PF01080//PF06068//PF00004//PF03286//PF07726//PF02562//PF02367//PF00910 IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Presenilin//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//Pox virus Ag35 surface protein//ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Threonylcarbamoyl adenosine biosynthesis protein TsaE//RNA helicase GO:0006281//GO:0006310//GO:0002949 DNA repair//DNA recombination//tRNA threonylcarbamoyladenosine modification GO:0003723//GO:0005524//GO:0003678//GO:0004190//GO:0003724//GO:0009378//GO:0016887 RNA binding//ATP binding//DNA helicase activity//aspartic-type endopeptidase activity//RNA helicase activity//four-way junction helicase activity//ATPase activity GO:0019031//GO:0005657//GO:0009379//GO:0016021 viral envelope//replication fork//Holliday junction helicase complex//integral component of membrane KOG0738 AAA+-type ATPase Cluster-8309.48826 BF_2 3.00 0.45 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48827 BF_2 20.33 1.56 834 642925847 XP_008190542.1 667 2.5e-67 PREDICTED: mitogen-activated protein kinase-binding protein 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48829 BF_2 1.00 3.05 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48830 BF_2 52.56 1.09 2309 642921254 XP_008192785.1 1716 1.6e-188 PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|642921256|ref|XP_008192787.1| PREDICTED: FK506-binding protein 59 [Tribolium castaneum]>gi|270006236|gb|EFA02684.1| hypothetical protein TcasGA2_TC008405 [Tribolium castaneum] -- -- -- -- -- K09571 FKBP4_5 FK506-binding protein 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K09571 Q9VL78 1056 2.2e-113 FK506-binding protein 59 OS=Drosophila melanogaster GN=FKBP59 PE=1 SV=1 PF13371//PF00515//PF04434//PF13176//PF13414//PF00254//PF13181//PF13174 Tetratricopeptide repeat//Tetratricopeptide repeat//SWIM zinc finger//Tetratricopeptide repeat//TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.48833 BF_2 431.13 5.03 3875 478254875 ENN75111.1 1428 6.5e-155 hypothetical protein YQE_08424, partial [Dendroctonus ponderosae] 642926583 XM_962896.2 307 3.84533e-157 PREDICTED: Tribolium castaneum lipoma-preferred partner homolog (LOC656358), transcript variant X2, mRNA K16676 LPP lipoma-prefererred partner http://www.genome.jp/dbget-bin/www_bget?ko:K16676 Q5F464 812 7.2e-85 Lipoma-preferred partner homolog OS=Gallus gallus GN=LPP PE=2 SV=1 PF06467//PF00412 MYM-type Zinc finger with FCS sequence motif//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1701 Focal adhesion adaptor protein Paxillin and related LIM proteins Cluster-8309.48834 BF_2 2.00 0.98 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48836 BF_2 11.00 0.41 1416 641670797 XP_008185349.1 430 1.3e-39 PREDICTED: uncharacterized protein LOC100570268 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07834//PF00665//PF00213 RanGAP1 C-terminal domain//Integrase core domain//ATP synthase delta (OSCP) subunit GO:0015986//GO:0007165//GO:0015074 ATP synthesis coupled proton transport//signal transduction//DNA integration GO:0005096//GO:0046933 GTPase activator activity//proton-transporting ATP synthase activity, rotational mechanism GO:0045259 proton-transporting ATP synthase complex -- -- Cluster-8309.48837 BF_2 569.00 6.29 4073 189241815 XP_971376.2 3970 0.0e+00 PREDICTED: FERM and PDZ domain-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14CM0 1079 8.3e-116 FERM and PDZ domain-containing protein 4 OS=Homo sapiens GN=FRMPD4 PE=1 SV=1 PF00595//PF00397//PF13180 PDZ domain (Also known as DHR or GLGF)//WW domain//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3552 FERM domain protein FRM-8 Cluster-8309.48839 BF_2 20.00 6.08 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48840 BF_2 54.03 0.75 3288 642922915 XP_008200450.1 3947 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 372 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2427 3.3e-272 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF02421//PF00071//PF06305//PF13304//PF01926//PF08477 Ferrous iron transport protein B//Ras family//Protein of unknown function (DUF1049)//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0007264//GO:0015684//GO:0006184 small GTPase mediated signal transduction//ferrous iron transport//obsolete GTP catabolic process GO:0003924//GO:0015093//GO:0005524//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//ATP binding//GTP binding GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.48841 BF_2 665.65 8.71 3484 642922917 XP_008200451.1 3946 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X2 [Tribolium castaneum] 642922916 XM_008202229.1 385 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5U3A7 2455 2.0e-275 Dynamin-like 120 kDa protein, mitochondrial OS=Danio rerio GN=opa1 PE=2 SV=1 PF02421//PF00071//PF06305//PF01926//PF08477 Ferrous iron transport protein B//Ras family//Protein of unknown function (DUF1049)//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0005525//GO:0015093 GTP binding//ferrous iron transmembrane transporter activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.48843 BF_2 1544.80 6.88 9686 642912705 XP_970640.2 7721 0.0e+00 PREDICTED: protein crumbs [Tribolium castaneum] -- -- -- -- -- K16681 CRB protein crumbs http://www.genome.jp/dbget-bin/www_bget?ko:K16681 P10040 4517 0.0e+00 Protein crumbs OS=Drosophila melanogaster GN=crb PE=1 SV=3 PF04053//PF00008//PF11857//PF07645//PF00400 Coatomer WD associated region//EGF-like domain//Domain of unknown function (DUF3377)//Calcium-binding EGF domain//WD domain, G-beta repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515//GO:0004222//GO:0005509 structural molecule activity//protein binding//metalloendopeptidase activity//calcium ion binding GO:0030117 membrane coat -- -- Cluster-8309.48845 BF_2 43.00 1.85 1262 -- -- -- -- -- 572311522 XM_006621426.1 43 7.02243e-11 PREDICTED: Apis dorsata glycine-rich cell wall structural protein 1-like (LOC102675835), transcript variant X10, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48852 BF_2 18.23 0.75 1303 270011080 EFA07528.1 535 7.8e-52 frazzled [Tribolium castaneum] 642929397 XM_008197598.1 54 5.57052e-17 PREDICTED: Tribolium castaneum neogenin (LOC663356), transcript variant X4, mRNA K06765 DCC deleted in colorectal carcinoma http://www.genome.jp/dbget-bin/www_bget?ko:K06765 P43146 202 1.3e-14 Netrin receptor DCC OS=Homo sapiens GN=DCC PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG4475 FOG: Immunoglobin and related proteins Cluster-8309.48853 BF_2 442.77 10.81 2000 642929394 XP_008195818.1 1991 1.8e-220 PREDICTED: neogenin isoform X2 [Tribolium castaneum] 642929397 XM_008197598.1 54 8.63255e-17 PREDICTED: Tribolium castaneum neogenin (LOC663356), transcript variant X4, mRNA K06766 NEO1 neogenin http://www.genome.jp/dbget-bin/www_bget?ko:K06766 Q92859 673 4.9e-69 Neogenin OS=Homo sapiens GN=NEO1 PE=1 SV=2 PF00041//PF13895//PF05790 Fibronectin type III domain//Immunoglobulin domain//Immunoglobulin C2-set domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane KOG4222 Axon guidance receptor Dscam Cluster-8309.48854 BF_2 553.29 5.22 4720 270011080 EFA07528.1 3052 0.0e+00 frazzled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90610 1088 8.7e-117 Neogenin (Fragment) OS=Gallus gallus PE=2 SV=1 PF06583//PF08465//PF00041//PF16656//PF01108 Neogenin C-terminus//Thymidine kinase from Herpesvirus C-terminal//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain//Tissue factor GO:0006771//GO:0006206//GO:0006230//GO:0019497 riboflavin metabolic process//pyrimidine nucleobase metabolic process//TMP biosynthetic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0004797//GO:0005524//GO:0005515 acid phosphatase activity//metal ion binding//thymidine kinase activity//ATP binding//protein binding GO:0016021 integral component of membrane KOG4221 Receptor mediating netrin-dependent axon guidance Cluster-8309.48855 BF_2 122.08 0.51 10340 642918328 XP_008199102.1 6476 0.0e+00 PREDICTED: otoferlin-like [Tribolium castaneum] 662203764 XM_008477009.1 153 4.18476e-71 PREDICTED: Diaphorina citri otoferlin-like (LOC103512257), partial mRNA -- -- -- -- Q5SPC5 3900 0.0e+00 Otoferlin OS=Danio rerio GN=otof PE=3 SV=1 PF00168//PF00957//PF08150 C2 domain//Synaptobrevin//FerB (NUC096) domain GO:0016192 vesicle-mediated transport GO:0005515 protein binding GO:0016021 integral component of membrane KOG1326 Membrane-associated protein FER-1 and related ferlins, contain multiple C2 domains Cluster-8309.48856 BF_2 934.92 4.02 10014 642924895 XP_008194087.1 5496 0.0e+00 PREDICTED: laminin subunit alpha-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K05637 LAMA1_2 laminin, alpha 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K05637 P19137 1398 2.1e-152 Laminin subunit alpha-1 OS=Mus musculus GN=Lama1 PE=1 SV=1 PF06008//PF06009 Laminin Domain I//Laminin Domain II GO:0045995//GO:0007165//GO:0030334//GO:0030155//GO:0007155 regulation of embryonic development//signal transduction//regulation of cell migration//regulation of cell adhesion//cell adhesion GO:0005102 receptor binding -- -- KOG1836 Extracellular matrix glycoprotein Laminin subunits alpha and gamma Cluster-8309.48863 BF_2 916.39 6.99 5774 642931136 XP_967600.2 3863 0.0e+00 PREDICTED: DNA-directed RNA polymerase, mitochondrial [Tribolium castaneum]>gi|270012086|gb|EFA08534.1| hypothetical protein TcasGA2_TC006188 [Tribolium castaneum] -- -- -- -- -- K10908 POLRMT, RPO41 DNA-directed RNA polymerase, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K10908 Q8BKF1 1977 8.8e-220 DNA-directed RNA polymerase, mitochondrial OS=Mus musculus GN=Polrmt PE=2 SV=1 PF03840//PF00940 Preprotein translocase SecG subunit//DNA-dependent RNA polymerase GO:0006144//GO:0009306//GO:0006351//GO:0015031//GO:0006206 purine nucleobase metabolic process//protein secretion//transcription, DNA-templated//protein transport//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0016740//GO:0015450 DNA-directed RNA polymerase activity//DNA binding//transferase activity//P-P-bond-hydrolysis-driven protein transmembrane transporter activity GO:0009941//GO:0016021//GO:0005730 chloroplast envelope//integral component of membrane//nucleolus KOG1038 Mitochondrial/chloroplast DNA-directed RNA polymerase RPO41, provides primers for DNA replication-initiation Cluster-8309.48864 BF_2 36.00 4.97 590 795009668 XP_011863002.1 262 1.6e-20 PREDICTED: uncharacterized protein LOC105559376 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00126//PF01047//PF01498//PF09339//PF00165 Bacterial regulatory helix-turn-helix protein, lysR family//MarR family//Transposase//IclR helix-turn-helix domain//Bacterial regulatory helix-turn-helix proteins, AraC family GO:0006355//GO:0015074//GO:0006313 regulation of transcription, DNA-templated//DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.48865 BF_2 646.09 5.44 5253 642914939 XP_008190450.1 1842 8.7e-203 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K13983 MOV10L1 putative helicase MOV10L1 http://www.genome.jp/dbget-bin/www_bget?ko:K13983 Q1LXK4 952 5.7e-101 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF00270//PF05970//PF13361//PF00580//PF00176//PF01637//PF02562//PF04851//PF00437//PF00004 DEAD/DEAH box helicase//PIF1-like helicase//UvrD-like helicase C-terminal domain//UvrD/REP helicase N-terminal domain//SNF2 family N-terminal domain//Archaeal ATPase//PhoH-like protein//Type III restriction enzyme, res subunit//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0006810//GO:0006281//GO:0000723 transport//DNA repair//telomere maintenance GO:0016787//GO:0003677//GO:0005524//GO:0003678//GO:0003676 hydrolase activity//DNA binding//ATP binding//DNA helicase activity//nucleic acid binding GO:0005657 replication fork KOG1804 RNA helicase Cluster-8309.48866 BF_2 423.66 5.26 3656 642914939 XP_008190450.1 1593 4.5e-174 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q1LXK4 922 1.2e-97 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF04851//PF01637//PF02562//PF00176//PF00580//PF00005//PF13361//PF05970//PF00270//PF00004//PF00437 Type III restriction enzyme, res subunit//Archaeal ATPase//PhoH-like protein//SNF2 family N-terminal domain//UvrD/REP helicase N-terminal domain//ABC transporter//UvrD-like helicase C-terminal domain//PIF1-like helicase//DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006281//GO:0006810//GO:0000723 DNA repair//transport//telomere maintenance GO:0003677//GO:0016787//GO:0003678//GO:0005524//GO:0016887//GO:0003676 DNA binding//hydrolase activity//DNA helicase activity//ATP binding//ATPase activity//nucleic acid binding GO:0005657 replication fork KOG1804 RNA helicase Cluster-8309.48867 BF_2 34.88 0.39 3996 270003759 EFA00207.1 1136 4.9e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.76753e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.48869 BF_2 23.92 0.55 2118 91089745 XP_975162.1 214 2.1e-14 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q57886 167 2.4e-10 RIO-type serine/threonine-protein kinase Rio1 OS=Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) GN=rio1 PE=3 SV=1 PF06293 Lipopolysaccharide kinase (Kdo/WaaP) family -- -- GO:0016773//GO:0005524//GO:0016772 phosphotransferase activity, alcohol group as acceptor//ATP binding//transferase activity, transferring phosphorus-containing groups GO:0016020 membrane KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.48870 BF_2 97.90 0.54 7824 642927006 XP_008195101.1 3700 0.0e+00 PREDICTED: protein disabled isoform X4 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 670 4.3e-68 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF07415//PF00640 Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphotyrosine interaction domain (PTB/PID) GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.48871 BF_2 224.54 1.53 6415 642937185 XP_008198729.1 2693 2.2e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.44727e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.1e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF05192//PF11744//PF00995//PF00023//PF13606 MutS domain III//Aluminium activated malate transporter//Sec1 family//Ankyrin repeat//Ankyrin repeat GO:0006298//GO:0016192//GO:0015743//GO:0006904 mismatch repair//vesicle-mediated transport//malate transport//vesicle docking involved in exocytosis GO:0030983//GO:0005524//GO:0005515 mismatched DNA binding//ATP binding//protein binding -- -- KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.48873 BF_2 41.62 0.66 2914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48875 BF_2 67.75 1.42 2289 91095137 XP_972151.1 753 7.2e-77 PREDICTED: calcium release-activated calcium channel protein 1 [Tribolium castaneum]>gi|270015634|gb|EFA12082.1| hypothetical protein TcasGA2_TC016005 [Tribolium castaneum] 170044795 XM_001849968.1 183 1.92764e-88 Culex quinquefasciatus conserved hypothetical protein, mRNA K16057 ORAI2 calcium release-activated calcium channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16057 Q9U6B8 637 8.4e-65 Calcium release-activated calcium channel protein 1 OS=Drosophila melanogaster GN=olf186-F PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4298 CAP-binding protein complex interacting protein 2 Cluster-8309.48877 BF_2 190.10 1.23 6741 642923720 XP_008193855.1 1439 6.0e-156 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0FGR8 565 5.5e-56 Extended synaptotagmin-2 OS=Homo sapiens GN=ESYT2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0005515//GO:0008289 protein binding//lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.48879 BF_2 95.62 1.03 4173 91078850 XP_971848.1 1166 1.7e-124 PREDICTED: uncharacterized protein LOC660531 [Tribolium castaneum]>gi|270004130|gb|EFA00578.1| hypothetical protein TcasGA2_TC003448 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03604 DNA directed RNA polymerase, 7 kDa subunit GO:0042318//GO:0006144//GO:0006351//GO:0006206 penicillin biosynthetic process//purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.48880 BF_2 63.61 2.92 1198 242018452 XP_002429689.1 404 1.1e-36 fatty acid synthase, putative [Pediculus humanus corporis]>gi|212514692|gb|EEB16951.1| fatty acid synthase, putative [Pediculus humanus corporis] 815792597 XM_012361475.1 47 3.97772e-13 PREDICTED: Linepithema humile fatty acid synthase-like (LOC105668856), mRNA K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 324 8.6e-29 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- GO:0042967//GO:0006633 acyl-carrier-protein biosynthetic process//fatty acid biosynthetic process GO:0016491//GO:0016297 oxidoreductase activity//acyl-[acyl-carrier-protein] hydrolase activity GO:0005835 fatty acid synthase complex KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.48881 BF_2 46.97 1.29 1811 91085253 XP_973335.1 609 2.8e-60 PREDICTED: uncharacterized protein LOC662125 [Tribolium castaneum]>gi|270009097|gb|EFA05545.1| hypothetical protein TcasGA2_TC015733 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00274 Fructose-bisphosphate aldolase class-I GO:0006096//GO:0006098//GO:0006020//GO:0006094//GO:0015976//GO:0006000//GO:0006013 glycolytic process//pentose-phosphate shunt//inositol metabolic process//gluconeogenesis//carbon utilization//fructose metabolic process//mannose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- -- -- Cluster-8309.48882 BF_2 981.94 4.54 9326 546681221 ERL91356.1 1694 2.2e-185 hypothetical protein D910_08688 [Dendroctonus ponderosae] 642927571 XM_008197097.1 82 1.11009e-31 PREDICTED: Tribolium castaneum cAMP-dependent protein kinase type II regulatory subunit (LOC661163), transcript variant X2, mRNA K04739 PRKAR cAMP-dependent protein kinase regulator http://www.genome.jp/dbget-bin/www_bget?ko:K04739 P81900 1231 4.5e-133 cAMP-dependent protein kinase type II regulatory subunit OS=Drosophila melanogaster GN=Pka-R2 PE=1 SV=2 PF00701//PF15494 Dihydrodipicolinate synthetase family//Scavenger receptor cysteine-rich domain GO:0008152 metabolic process GO:0016829 lyase activity GO:0016020 membrane KOG1113 cAMP-dependent protein kinase types I and II, regulatory subunit Cluster-8309.48884 BF_2 257.51 2.98 3897 332375210 AEE62746.1 1041 4.9e-110 unknown [Dendroctonus ponderosae]>gi|478254335|gb|ENN74587.1| hypothetical protein YQE_08710, partial [Dendroctonus ponderosae]>gi|546674053|gb|ERL85541.1| hypothetical protein D910_02960 [Dendroctonus ponderosae] -- -- -- -- -- K02895 RP-L24, MRPL24, rplX large subunit ribosomal protein L24 http://www.genome.jp/dbget-bin/www_bget?ko:K02895 Q29MA5 828 1.0e-86 Probable 39S ribosomal protein L24, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL24 PE=3 SV=1 PF13482 RNase_H superfamily -- -- GO:0003676 nucleic acid binding -- -- KOG3801 Uncharacterized conserved protein BCN92 Cluster-8309.48886 BF_2 59.22 0.71 3762 642911809 XP_008200752.1 2003 1.3e-221 PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911811|ref|XP_008200753.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911813|ref|XP_008200754.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 739 2.0e-76 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48887 BF_2 3.00 0.99 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48888 BF_2 16.00 0.40 1951 546682247 ERL92208.1 244 6.4e-18 hypothetical protein D910_09528, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08573//PF07578//PF03122 DNA repair protein endonuclease SAE2/CtIP C-terminus//Lipid A Biosynthesis N-terminal domain//Herpes virus major capsid protein GO:0009245//GO:0006281//GO:0000077//GO:0006308 lipid A biosynthetic process//DNA repair//DNA damage checkpoint//DNA catabolic process GO:0005198//GO:0008915//GO:0000014 structural molecule activity//lipid-A-disaccharide synthase activity//single-stranded DNA endodeoxyribonuclease activity GO:0019028 viral capsid -- -- Cluster-8309.48891 BF_2 155.48 2.26 3168 91083687 XP_969193.1 734 1.6e-74 PREDICTED: uncharacterized protein LOC657653 [Tribolium castaneum]>gi|642924327|ref|XP_008194250.1| PREDICTED: uncharacterized protein LOC657653 [Tribolium castaneum]>gi|642924330|ref|XP_008194251.1| PREDICTED: uncharacterized protein LOC657653 [Tribolium castaneum]>gi|642924332|ref|XP_008194252.1| PREDICTED: uncharacterized protein LOC657653 [Tribolium castaneum]>gi|270006813|gb|EFA03261.1| hypothetical protein TcasGA2_TC013195 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48894 BF_2 79.90 0.65 5393 270002310 EEZ98757.1 2340 1.6e-260 hypothetical protein TcasGA2_TC001321 [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 O43795 1233 1.5e-133 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF06414//PF00063//PF00612//PF09293//PF06017//PF00437 Zeta toxin//Myosin head (motor domain)//IQ calmodulin-binding motif//T4 RNase H, C terminal//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0005515//GO:0003677//GO:0003824//GO:0005524//GO:0003774//GO:0016301 protein binding//DNA binding//catalytic activity//ATP binding//motor activity//kinase activity GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.48896 BF_2 34.96 0.60 2741 332372500 AEE61392.1 393 4.8e-35 unknown [Dendroctonus ponderosae]>gi|478254478|gb|ENN74727.1| hypothetical protein YQE_08694, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P1S2 134 2.1e-06 Protein C3orf33 OS=Homo sapiens GN=C3orf33 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48897 BF_2 139.00 1.39 4472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01810 LysE type translocator GO:0006865 amino acid transport -- -- GO:0016020 membrane -- -- Cluster-8309.48899 BF_2 1095.44 26.80 1997 546673691 ERL85252.1 2493 1.1e-278 hypothetical protein D910_02673 [Dendroctonus ponderosae] 826416467 XM_012667541.1 210 1.64268e-103 PREDICTED: Monomorium pharaonis asparagine--tRNA ligase, cytoplasmic (LOC105828947), mRNA K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q2KJG3 2079 4.5e-232 Asparagine--tRNA ligase, cytoplasmic OS=Bos taurus GN=NARS PE=2 SV=3 PF00152//PF01409//PF00237//PF01336 tRNA synthetases class II (D, K and N)//tRNA synthetases class II core domain (F)//Ribosomal protein L22p/L17e//OB-fold nucleic acid binding domain GO:0043039//GO:0042254//GO:0006418//GO:0006412 tRNA aminoacylation//ribosome biogenesis//tRNA aminoacylation for protein translation//translation GO:0004812//GO:0003676//GO:0003735//GO:0000166//GO:0000049//GO:0005524 aminoacyl-tRNA ligase activity//nucleic acid binding//structural constituent of ribosome//nucleotide binding//tRNA binding//ATP binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG0555 Asparaginyl-tRNA synthetase Cluster-8309.489 BF_2 4.00 0.97 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48901 BF_2 227.22 15.19 913 91087039 XP_974482.1 911 1.4e-95 PREDICTED: AP-3 complex subunit sigma-2 isoform X1 [Tribolium castaneum]>gi|270009628|gb|EFA06076.1| hypothetical protein TcasGA2_TC008912 [Tribolium castaneum] 505849574 XM_004618186.1 123 1.69829e-55 PREDICTED: Sorex araneus adaptor-related protein complex 3, sigma 1 subunit (AP3S1), mRNA K12399 AP3S AP-3 complex subunit sigma http://www.genome.jp/dbget-bin/www_bget?ko:K12399 Q1JQA3 730 5.5e-76 AP-3 complex subunit sigma-2 OS=Bos taurus GN=AP3S2 PE=2 SV=1 -- -- GO:0016192//GO:0015031//GO:0006886 vesicle-mediated transport//protein transport//intracellular protein transport GO:0008565 protein transporter activity GO:0030117 membrane coat KOG0936 Clathrin adaptor complex, small subunit Cluster-8309.48902 BF_2 299.00 2.34 5639 642919889 XP_008192111.1 3942 0.0e+00 PREDICTED: transmembrane and TPR repeat-containing protein CG4050-like [Tribolium castaneum]>gi|270005381|gb|EFA01829.1| hypothetical protein TcasGA2_TC007431 [Tribolium castaneum] 642919888 XM_008193889.1 143 8.24581e-66 PREDICTED: Tribolium castaneum transmembrane and TPR repeat-containing protein CG4050-like (LOC663014), mRNA -- -- -- -- Q7K4B6 2515 3.5e-282 Transmembrane and TPR repeat-containing protein CG4050 OS=Drosophila melanogaster GN=CG4050 PE=2 SV=1 PF13176//PF13414//PF13371//PF00515//PF13374//PF00619//PF13174//PF10579//PF04977//PF13181//PF08631 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Caspase recruitment domain//Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Septum formation initiator//Tetratricopeptide repeat//Meiosis protein SPO22/ZIP4 like GO:0042981//GO:0007268//GO:0051321//GO:0007049 regulation of apoptotic process//synaptic transmission//meiotic cell cycle//cell cycle GO:0033130//GO:0005515//GO:0043495 acetylcholine receptor binding//protein binding//protein anchor -- -- KOG1124 FOG: TPR repeat Cluster-8309.48903 BF_2 97.84 0.65 6552 642929489 XP_008195859.1 4654 0.0e+00 PREDICTED: ADAMTS-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82987 811 1.6e-84 ADAMTS-like protein 3 OS=Homo sapiens GN=ADAMTSL3 PE=1 SV=4 PF13895//PF08686 Immunoglobulin domain//PLAC (protease and lacunin) domain -- -- GO:0008233//GO:0005515 peptidase activity//protein binding -- -- KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.48905 BF_2 786.81 11.05 3265 91095167 XP_968412.1 623 1.2e-61 PREDICTED: PRA1 family protein 3 [Tribolium castaneum]>gi|270015793|gb|EFA12241.1| hypothetical protein TcasGA2_TC016173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5J9 362 9.2e-33 PRA1 family protein 3 OS=Mus musculus GN=Arl6ip5 PE=1 SV=2 PF04382//PF02313 SAB domain//Fumarate reductase subunit D GO:0006106//GO:0030866 fumarate metabolic process//cortical actin cytoskeleton organization GO:0008092 cytoskeletal protein binding GO:0005856//GO:0016020 cytoskeleton//membrane KOG4050 Glutamate transporter EAAC1-interacting protein GTRAP3-18 Cluster-8309.48906 BF_2 3.54 1.06 426 546685092 ERL94619.1 231 4.5e-17 hypothetical protein D910_11896 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5F433 148 7.8e-09 PRA1 family protein 3 OS=Gallus gallus GN=ARL6IP5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4050 Glutamate transporter EAAC1-interacting protein GTRAP3-18 Cluster-8309.48908 BF_2 96.51 1.33 3328 91095167 XP_968412.1 623 1.2e-61 PREDICTED: PRA1 family protein 3 [Tribolium castaneum]>gi|270015793|gb|EFA12241.1| hypothetical protein TcasGA2_TC016173 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5J9 362 9.4e-33 PRA1 family protein 3 OS=Mus musculus GN=Arl6ip5 PE=1 SV=2 PF04382//PF02313 SAB domain//Fumarate reductase subunit D GO:0006106//GO:0030866 fumarate metabolic process//cortical actin cytoskeleton organization GO:0008092 cytoskeletal protein binding GO:0005856//GO:0016020 cytoskeleton//membrane KOG4050 Glutamate transporter EAAC1-interacting protein GTRAP3-18 Cluster-8309.48909 BF_2 639.35 15.62 1999 91083715 XP_970185.1 1499 2.0e-163 PREDICTED: RNA-binding protein 45 [Tribolium castaneum]>gi|270007883|gb|EFA04331.1| hypothetical protein TcasGA2_TC014625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUH3 745 2.2e-77 RNA-binding protein 45 OS=Homo sapiens GN=RBM45 PE=1 SV=1 PF08777//PF16367//PF00076//PF08675 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding domain GO:0006402//GO:0051252 mRNA catabolic process//regulation of RNA metabolic process GO:0003723//GO:0097159//GO:1901363//GO:0004535//GO:0003676//GO:0046872 RNA binding//organic cyclic compound binding//heterocyclic compound binding//poly(A)-specific ribonuclease activity//nucleic acid binding//metal ion binding GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.48911 BF_2 120.89 1.77 3151 91083715 XP_970185.1 1379 2.6e-149 PREDICTED: RNA-binding protein 45 [Tribolium castaneum]>gi|270007883|gb|EFA04331.1| hypothetical protein TcasGA2_TC014625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUH3 682 7.0e-70 RNA-binding protein 45 OS=Homo sapiens GN=RBM45 PE=1 SV=1 PF14552//PF08777//PF08675//PF00076//PF16367 Tautomerase enzyme//RNA binding motif//RNA binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0051252//GO:0006725//GO:0006402 regulation of RNA metabolic process//cellular aromatic compound metabolic process//mRNA catabolic process GO:0097159//GO:0003676//GO:0004535//GO:1901363//GO:0046872//GO:0003723//GO:0016853 organic cyclic compound binding//nucleic acid binding//poly(A)-specific ribonuclease activity//heterocyclic compound binding//metal ion binding//RNA binding//isomerase activity GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.48912 BF_2 32.00 0.45 3243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48913 BF_2 17.18 0.32 2551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48917 BF_2 7.41 1.29 528 478253952 ENN74244.1 431 3.6e-40 hypothetical protein YQE_09216, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48920 BF_2 68.06 3.58 1082 91081585 XP_975324.1 389 5.5e-35 PREDICTED: protein FAM177A1 [Tribolium castaneum]>gi|270005105|gb|EFA01553.1| hypothetical protein TcasGA2_TC007114 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6QLZ5 227 1.4e-17 Protein FAM177A1 OS=Bos taurus GN=FAM177A1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48921 BF_2 79.00 2.80 1466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48924 BF_2 28.14 0.38 3345 270007768 EFA04216.1 1199 2.0e-128 hypothetical protein TcasGA2_TC014465 [Tribolium castaneum] 170029938 XM_001842796.1 262 3.43379e-132 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 981 1.6e-104 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF00514//PF11698//PF01602//PF02985//PF11538//PF10508//PF01749 Armadillo/beta-catenin-like repeat//V-ATPase subunit H//Adaptin N terminal region//HEAT repeat//Snurportin1//Proteasome non-ATPase 26S subunit//Importin beta binding domain GO:0006606//GO:0043248//GO:0015031//GO:0016192//GO:0015991//GO:0006886 protein import into nucleus//proteasome assembly//protein transport//vesicle-mediated transport//ATP hydrolysis coupled proton transport//intracellular protein transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0005737//GO:0005634//GO:0000221 membrane coat//cytoplasm//nucleus//vacuolar proton-transporting V-type ATPase, V1 domain KOG0166 Karyopherin (importin) alpha Cluster-8309.48925 BF_2 143.87 0.59 10427 91083259 XP_974150.1 3703 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase Su(dx) [Tribolium castaneum]>gi|270007721|gb|EFA04169.1| hypothetical protein TcasGA2_TC014416 [Tribolium castaneum] 768410327 XM_011559226.1 460 0 PREDICTED: Plutella xylostella E3 ubiquitin-protein ligase Su(dx)-like (LOC105388335), mRNA K05633 AIP5, WWP1 atrophin-1 interacting protein 5 (WW domain containing E3 ubiquitin protein ligase 1) http://www.genome.jp/dbget-bin/www_bget?ko:K05633 Q9Y0H4 2665 2.6e-299 E3 ubiquitin-protein ligase Su(dx) OS=Drosophila melanogaster GN=Su(dx) PE=1 SV=1 PF05430//PF02891//PF00397//PF00168//PF00632//PF01155 S-adenosyl-L-methionine-dependent methyltransferase//MIZ/SP-RING zinc finger//WW domain//C2 domain//HECT-domain (ubiquitin-transferase)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464//GO:0016567//GO:0055114 cellular protein modification process//protein ubiquitination//oxidation-reduction process GO:0005515//GO:0016151//GO:0004842//GO:0008270//GO:0016645 protein binding//nickel cation binding//ubiquitin-protein transferase activity//zinc ion binding//oxidoreductase activity, acting on the CH-NH group of donors GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.48926 BF_2 148.50 1.13 5762 642920448 XP_008192355.1 2534 5.5e-283 PREDICTED: nuclear factor related to kappa-B-binding protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K11671 NFRKB, INO80G nuclear factor related to kappa-B-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11671 Q6PIJ4 679 2.8e-69 Nuclear factor related to kappa-B-binding protein OS=Mus musculus GN=Nfrkb PE=2 SV=1 PF10597//PF00397 U5-snRNA binding site 2 of PrP8//WW domain -- -- GO:0030623//GO:0005515 U5 snRNA binding//protein binding -- -- KOG1927 R-kappa-B and related transcription factors Cluster-8309.48927 BF_2 98.60 0.80 5435 642920450 XP_975645.2 2534 5.2e-283 PREDICTED: nuclear factor related to kappa-B-binding protein isoform X2 [Tribolium castaneum]>gi|270005227|gb|EFA01675.1| hypothetical protein TcasGA2_TC007248 [Tribolium castaneum] -- -- -- -- -- K11671 NFRKB, INO80G nuclear factor related to kappa-B-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11671 Q6P4R8 679 2.7e-69 Nuclear factor related to kappa-B-binding protein OS=Homo sapiens GN=NFRKB PE=1 SV=2 PF00397//PF10597 WW domain//U5-snRNA binding site 2 of PrP8 -- -- GO:0030623//GO:0005515 U5 snRNA binding//protein binding -- -- KOG1927 R-kappa-B and related transcription factors Cluster-8309.48929 BF_2 4.00 1.47 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48931 BF_2 24.37 0.48 2429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48932 BF_2 940.76 21.60 2109 91079134 XP_975446.1 995 5.7e-105 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|642916464|ref|XP_008191038.1| PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270004224|gb|EFA00672.1| hypothetical protein TcasGA2_TC003549 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q58DT4 515 1.1e-50 Pyrroline-5-carboxylate reductase 1, mitochondrial OS=Bos taurus GN=PYCR1 PE=2 SV=1 PF03446//PF01408 NAD binding domain of 6-phosphogluconate dehydrogenase//Oxidoreductase family, NAD-binding Rossmann fold GO:0019521//GO:0055114//GO:0006098//GO:0055129//GO:0006525//GO:0006561 D-gluconate metabolic process//oxidation-reduction process//pentose-phosphate shunt//L-proline biosynthetic process//arginine metabolic process//proline biosynthetic process GO:0004616//GO:0000166//GO:0004735//GO:0016491 phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding//pyrroline-5-carboxylate reductase activity//oxidoreductase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.48934 BF_2 69.69 4.28 968 642928567 XP_008199961.1 505 1.7e-48 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 391 1.2e-36 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.48941 BF_2 337.00 4.27 3587 91080401 XP_966987.1 1815 8.1e-200 PREDICTED: ankyrin repeat and LEM domain-containing protein 2 [Tribolium castaneum]>gi|270005746|gb|EFA02194.1| hypothetical protein TcasGA2_TC007850 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TP65 753 4.6e-78 Ankyrin repeat and LEM domain-containing protein 2 OS=Rattus norvegicus GN=Ankle2 PE=2 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.48942 BF_2 25.00 1.81 866 751237885 XP_011172858.1 248 9.8e-19 PREDICTED: uncharacterized protein LOC105205238 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48946 BF_2 524.49 4.26 5436 189237182 XP_001808720.1 2170 8.4e-241 PREDICTED: FERM, RhoGEF and pleckstrin domain-containing protein 2-like [Tribolium castaneum] 642922446 XM_008194952.1 244 5.6835e-122 PREDICTED: Tribolium castaneum titin-like (LOC655359), mRNA K06082 FARP2, FRG FERM, RhoGEF and pleckstrin domain protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06082 Q91VS8 1096 1.2e-117 FERM, RhoGEF and pleckstrin domain-containing protein 2 OS=Mus musculus GN=Farp2 PE=1 SV=2 PF00621//PF08172 RhoGEF domain//CASP C terminal GO:0043087//GO:0035023//GO:0006891 regulation of GTPase activity//regulation of Rho protein signal transduction//intra-Golgi vesicle-mediated transport GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0030173 integral component of Golgi membrane KOG3531 Rho guanine nucleotide exchange factor CDEP Cluster-8309.48949 BF_2 312.38 6.68 2242 270005270 EFA01718.1 1895 2.7e-209 hypothetical protein TcasGA2_TC007298 [Tribolium castaneum] 642920293 XM_008194065.1 444 0 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 9-like (LOC664510), transcript variant X2, mRNA K04417 MAP3K9, MLK1 mitogen-activated protein kinase kinase kinase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04417 Q3U1V8 1312 4.4e-143 Mitogen-activated protein kinase kinase kinase 9 OS=Mus musculus GN=Map3k9 PE=2 SV=2 PF07714//PF00018//PF14604//PF00069 Protein tyrosine kinase//SH3 domain//Variant SH3 domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- -- -- Cluster-8309.48950 BF_2 232.29 3.87 2795 478258781 ENN78804.1 2058 4.2e-228 hypothetical protein YQE_04741, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5ZIL9 960 3.6e-102 KIF1-binding protein homolog OS=Gallus gallus GN=kbp PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48951 BF_2 3.00 2.56 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48954 BF_2 4.70 1.12 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03492 SAM dependent carboxyl methyltransferase -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.48956 BF_2 367.44 4.69 3563 270015294 EFA11742.1 680 3.3e-68 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.48958 BF_2 1401.58 13.74 4553 123463203 XP_001316939.1 238 7.5e-17 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121899660|gb|EAY04716.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q4UMH6 222 2.2e-16 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF04083//PF09174 Partial alpha/beta-hydrolase lipase region//Maf1 regulator GO:0016480//GO:0006629 negative regulation of transcription from RNA polymerase III promoter//lipid metabolic process -- -- -- -- KOG4177 Ankyrin Cluster-8309.48959 BF_2 28.30 6.92 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03492 SAM dependent carboxyl methyltransferase -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.48960 BF_2 681.56 9.61 3255 270015294 EFA11742.1 680 3.0e-68 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06363 Picornaviridae P3A protein -- -- -- -- GO:0019012 virion -- -- Cluster-8309.48962 BF_2 192.93 3.44 2632 546674012 ERL85505.1 2670 4.3e-299 hypothetical protein D910_02924 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q16ZN9 1594 1.0e-175 Conserved oligomeric Golgi complex subunit 3 OS=Aedes aegypti GN=Cog3 PE=3 SV=1 PF04048//PF04136 Sec8 exocyst complex component specific domain//Sec34-like family GO:0015031//GO:0006886//GO:0006904 protein transport//intracellular protein transport//vesicle docking involved in exocytosis -- -- GO:0016020//GO:0000145//GO:0005801 membrane//exocyst//cis-Golgi network KOG2604 Subunit of cis-Golgi transport vesicle tethering complex - Sec34p Cluster-8309.48964 BF_2 79.10 1.86 2062 91087975 XP_973241.1 1095 1.4e-116 PREDICTED: wiskott-Aldrich syndrome protein family member 3 [Tribolium castaneum]>gi|270012052|gb|EFA08500.1| hypothetical protein TcasGA2_TC006152 [Tribolium castaneum] -- -- -- -- -- K06220 WASF WAS protein family http://www.genome.jp/dbget-bin/www_bget?ko:K06220 Q9UPY6 601 1.1e-60 Wiskott-Aldrich syndrome protein family member 3 OS=Homo sapiens GN=WASF3 PE=1 SV=2 PF07415//PF03358 Gammaherpesvirus latent membrane protein (LMP2) protein//NADPH-dependent FMN reductase GO:0019042 viral latency GO:0016491//GO:0003779 oxidoreductase activity//actin binding GO:0033644 host cell membrane KOG1830 Wiskott Aldrich syndrome proteins Cluster-8309.48967 BF_2 12.00 0.76 950 391339337 XP_003744008.1 1192 3.7e-128 PREDICTED: catalase-like [Metaseiulus occidentalis] 391339336 XM_003743960.1 229 2.10302e-114 PREDICTED: Metaseiulus occidentalis catalase-like (LOC100908415), mRNA K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 Q2I6W4 1132 1.4e-122 Catalase OS=Callithrix jacchus GN=CAT PE=2 SV=3 PF00199 Catalase GO:0006568//GO:0015947//GO:0006979//GO:0006804//GO:0055114 tryptophan metabolic process//methane metabolic process//response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004096//GO:0020037 catalase activity//heme binding -- -- KOG0047 Catalase Cluster-8309.48969 BF_2 173.00 3.94 2125 91092900 XP_970994.1 993 9.9e-105 PREDICTED: WW domain-binding protein 11 [Tribolium castaneum]>gi|270003035|gb|EEZ99482.1| hypothetical protein TcasGA2_TC000057 [Tribolium castaneum] 346710668 AK382553.1 92 6.89984e-38 Bombyx mori mRNA, clone: fdpe20P17 K12866 WBP11, NPWBP WW domain-binding protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K12866 Q9Y2W2 452 2.2e-43 WW domain-binding protein 11 OS=Homo sapiens GN=WBP11 PE=1 SV=1 PF09429 WW domain binding protein 11 GO:0006396 RNA processing -- -- -- -- KOG4672 Uncharacterized conserved low complexity protein Cluster-8309.48970 BF_2 916.71 11.58 3600 642932794 XP_974082.2 1670 5.3e-183 PREDICTED: dual specificity mitogen-activated protein kinase kinase 4 isoform X2 [Tribolium castaneum] 755973707 XM_011308799.1 131 2.45761e-59 PREDICTED: Fopius arisanus dual specificity mitogen-activated protein kinase kinase 4-like (LOC105268902), mRNA K04430 MAP2K4, MKK4 mitogen-activated protein kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04430 P47809 1129 1.2e-121 Dual specificity mitogen-activated protein kinase kinase 4 OS=Mus musculus GN=Map2k4 PE=1 SV=2 PF00069//PF04196//PF07714 Protein kinase domain//Bunyavirus RNA dependent RNA polymerase//Protein tyrosine kinase GO:0006468//GO:0006144//GO:0006351//GO:0019079 protein phosphorylation//purine nucleobase metabolic process//transcription, DNA-templated//viral genome replication GO:0005524//GO:0004672//GO:0003968 ATP binding//protein kinase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG1006 Mitogen-activated protein kinase (MAPK) kinase MKK4 Cluster-8309.48972 BF_2 21.04 2.57 630 91089745 XP_975162.1 252 2.5e-19 PREDICTED: serine/threonine-protein kinase RIO3 [Tribolium castaneum]>gi|270011304|gb|EFA07752.1| hypothetical protein TcasGA2_TC005306 [Tribolium castaneum] -- -- -- -- -- K08872 RIOK3, SUDD RIO kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08872 Q1RMT7 205 2.9e-15 Serine/threonine-protein kinase RIO3 OS=Bos taurus GN=RIOK3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2270 Serine/threonine protein kinase involved in cell cycle control Cluster-8309.48977 BF_2 33.05 2.16 928 642925141 XP_008194443.1 278 3.5e-22 PREDICTED: sex lethal isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48980 BF_2 36.96 0.35 4643 91088115 XP_969791.1 1930 4.8e-213 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 379 0 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 1694 4.6e-187 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF01105//PF04851//PF00270 emp24/gp25L/p24 family/GOLD//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0006810 transport GO:0005524//GO:0016787//GO:0003677//GO:0003676//GO:0008026 ATP binding//hydrolase activity//DNA binding//nucleic acid binding//ATP-dependent helicase activity GO:0016021 integral component of membrane KOG0330 ATP-dependent RNA helicase Cluster-8309.48982 BF_2 299.07 14.72 1137 91088115 XP_969791.1 1073 2.8e-114 PREDICTED: probable ATP-dependent RNA helicase DDX47 [Tribolium castaneum]>gi|270012107|gb|EFA08555.1| hypothetical protein TcasGA2_TC006210 [Tribolium castaneum] 820838030 XM_003690796.2 238 2.5145e-119 PREDICTED: Apis florea probable ATP-dependent RNA helicase DDX47 (LOC100864339), mRNA K14777 DDX47, RRP3 ATP-dependent RNA helicase DDX47/RRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K14777 Q29S22 962 8.5e-103 Probable ATP-dependent RNA helicase DDX47 OS=Bos taurus GN=DDX47 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0005524//GO:0003677//GO:0016787//GO:0003676//GO:0008026 ATP binding//DNA binding//hydrolase activity//nucleic acid binding//ATP-dependent helicase activity -- -- KOG0330 ATP-dependent RNA helicase Cluster-8309.48984 BF_2 25.00 0.63 1956 478253983 ENN74275.1 451 6.4e-42 hypothetical protein YQE_09247, partial [Dendroctonus ponderosae]>gi|546673743|gb|ERL85299.1| hypothetical protein D910_02720 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48986 BF_2 157.00 7.12 1209 91087143 XP_975288.1 1046 4.0e-111 PREDICTED: exosome complex component MTR3 [Tribolium castaneum] -- -- -- -- -- K12587 MTR3, EXOSC6 exosome complex component MTR3 http://www.genome.jp/dbget-bin/www_bget?ko:K12587 Q6P0I8 438 5.3e-42 Exosome complex component MTR3 OS=Danio rerio GN=exosc6 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1068 Exosomal 3'-5' exoribonuclease complex, subunit Rrp41 and related exoribonucleases Cluster-8309.48987 BF_2 143.17 1.42 4515 642910521 XP_008200247.1 918 1.0e-95 PREDICTED: muscle M-line assembly protein unc-89-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48988 BF_2 541.65 3.97 6000 91082203 XP_972014.1 3609 0.0e+00 PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922206|ref|XP_008193062.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|642922209|ref|XP_008193063.1| PREDICTED: uncharacterized protein LOC660712 [Tribolium castaneum]>gi|270007229|gb|EFA03677.1| hypothetical protein TcasGA2_TC013779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02466 665 1.2e-67 Insulin-like peptide receptor OS=Branchiostoma lanceolatum PE=2 SV=1 PF00069//PF03139//PF07714//PF05676 Protein kinase domain//Vanadium/alternative nitrogenase delta subunit//Protein tyrosine kinase//NADH-ubiquinone oxidoreductase B18 subunit (NDUFB7) GO:0015992//GO:0055114//GO:0006118//GO:0006814//GO:0006468//GO:0009399//GO:0006120//GO:0006807//GO:0006744//GO:0016310//GO:0019337 proton transport//oxidation-reduction process//obsolete electron transport//sodium ion transport//protein phosphorylation//nitrogen fixation//mitochondrial electron transport, NADH to ubiquinone//nitrogen compound metabolic process//ubiquinone biosynthetic process//phosphorylation//tetrachloroethylene catabolic process GO:0016163//GO:0008137//GO:0000166//GO:0005524//GO:0004672//GO:0003954 nitrogenase activity//NADH dehydrogenase (ubiquinone) activity//nucleotide binding//ATP binding//protein kinase activity//NADH dehydrogenase activity GO:0016610//GO:0005739 nitrogenase complex//mitochondrion KOG4258 Insulin/growth factor receptor (contains protein kinase domain) Cluster-8309.4899 BF_2 24.00 0.64 1855 91078176 XP_967241.1 1502 8.2e-164 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1262 2.3e-137 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.48990 BF_2 120.47 1.39 3906 642925947 XP_008194707.1 681 2.7e-68 PREDICTED: uncharacterized protein LOC103313387, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48993 BF_2 25.00 9.25 399 383847897 XP_003699589.1 422 3.0e-39 PREDICTED: 60S ribosomal protein L35a [Megachile rotundata] 262401316 FJ774840.1 179 5.24099e-87 Scylla paramamosain ribosomal protein L35A mRNA, partial cds K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 P61272 380 9.1e-36 60S ribosomal protein L35a OS=Macaca fascicularis GN=RPL35A PE=3 SV=1 PF01247 Ribosomal protein L35Ae GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0887 60S ribosomal protein L35A/L37 Cluster-8309.48994 BF_2 212.58 5.21 1993 91083711 XP_969979.1 1185 5.1e-127 PREDICTED: dnaJ homolog subfamily B member 13 [Tribolium castaneum]>gi|270006809|gb|EFA03257.1| hypothetical protein TcasGA2_TC013191 [Tribolium castaneum] -- -- -- -- -- K09519 DNAJB13 DnaJ homolog subfamily B member 13 http://www.genome.jp/dbget-bin/www_bget?ko:K09519 Q80Y75 555 2.3e-55 DnaJ homolog subfamily B member 13 OS=Mus musculus GN=Dnajb13 PE=2 SV=1 PF04961//PF11744 Formiminotransferase-cyclodeaminase//Aluminium activated malate transporter GO:0044237//GO:0015743//GO:0006457 cellular metabolic process//malate transport//protein folding GO:0051082//GO:0031072//GO:0003824 unfolded protein binding//heat shock protein binding//catalytic activity -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.48995 BF_2 133.90 3.53 1872 546683908 ERL93656.1 1982 1.8e-219 hypothetical protein D910_10944 [Dendroctonus ponderosae] 195130912 XM_002009859.1 179 2.62887e-86 Drosophila mojavensis GI14989 (Dmoj\GI14989), mRNA -- -- -- -- Q80XJ3 846 4.0e-89 Tetratricopeptide repeat protein 28 OS=Mus musculus GN=Ttc28 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48996 BF_2 88.38 1.62 2567 607361054 EZA55356.1 530 5.8e-51 Putative nuclease HARBI1, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q6AZB8 284 8.0e-24 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF01609//PF03213 Transposase DDE domain//Poxvirus P35 protein GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity GO:0019031 viral envelope -- -- Cluster-8309.48997 BF_2 2.90 12.67 257 642915333 XP_008190576.1 246 4.9e-19 PREDICTED: techylectin-5B-like [Tribolium castaneum] -- -- -- -- -- K06252 TN tenascin http://www.genome.jp/dbget-bin/www_bget?ko:K06252 Q5XK91 219 2.7e-17 Fibrinogen C domain-containing protein 1-B OS=Xenopus laevis GN=fibcd1-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.48998 BF_2 121.70 1.27 4309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.48999 BF_2 22.16 0.46 2300 642923366 XP_973695.2 486 6.6e-46 PREDICTED: uncharacterized protein LOC662511 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.4900 BF_2 33.00 1.01 1655 829782570 XP_012623491.1 170 2.1e-09 PREDICTED: piggyBac transposable element-derived protein 4 isoform X1 [Microcebus murinus]>gi|829782575|ref|XP_012623492.1| PREDICTED: piggyBac transposable element-derived protein 4 isoform X1 [Microcebus murinus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49000 BF_2 321.35 1.41 9849 270006808 EFA03256.1 1963 1.5e-216 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] 642924343 XM_008196035.1 453 0 PREDICTED: Tribolium castaneum voltage-gated potassium channel subunit beta-2 (LOC658668), mRNA K04883 KCNAB2 potassium voltage-gated channel Shaker-related subfamily A, beta member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04883 Q27955 988 7.2e-105 Voltage-gated potassium channel subunit beta-2 OS=Bos taurus GN=KCNAB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB Cluster-8309.49003 BF_2 596.72 23.35 1356 642911486 XP_008199444.1 557 2.3e-54 PREDICTED: Na(+)/H(+) exchange regulatory cofactor NHE-RF2 [Tribolium castaneum]>gi|270014790|gb|EFA11238.1| hypothetical protein TcasGA2_TC010770 [Tribolium castaneum] -- -- -- -- -- K13358 SLC9A3R2, NHERF2 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 http://www.genome.jp/dbget-bin/www_bget?ko:K13358 Q5ZM14 257 5.7e-21 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 OS=Gallus gallus GN=SLC9A3R1 PE=2 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.49004 BF_2 107.70 2.23 2305 332376577 AEE63428.1 1040 3.8e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 Q54HL4 550 1.0e-54 Gamma-glutamyl hydrolase B OS=Dictyostelium discoideum GN=gghB PE=3 SV=1 PF07722//PF11522 Peptidase C26//Yeast phosphatidylinositol-4-OH kinase Pik1 GO:0006541 glutamine metabolic process GO:0016773//GO:0016787 phosphotransferase activity, alcohol group as acceptor//hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.49005 BF_2 88.37 1.28 3185 642924174 XP_008194038.1 1263 7.3e-136 PREDICTED: LOW QUALITY PROTEIN: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like [Tribolium castaneum] -- -- -- -- -- K05544 DUS3 tRNA-dihydrouridine synthase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05544 Q28BT8 798 2.5e-83 tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like OS=Xenopus tropicalis GN=dus3l PE=2 SV=2 PF00642//PF01207 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Dihydrouridine synthase (Dus) GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0017150//GO:0046872//GO:0050660 tRNA dihydrouridine synthase activity//metal ion binding//flavin adenine dinucleotide binding -- -- KOG2333 Uncharacterized conserved protein Cluster-8309.49006 BF_2 323.74 3.41 4256 642937533 XP_008199086.1 1403 5.7e-152 PREDICTED: F-box only protein 9 [Tribolium castaneum] -- -- -- -- -- K10295 FBXO9 F-box protein 9 http://www.genome.jp/dbget-bin/www_bget?ko:K10295 Q3ZBT2 828 1.1e-86 F-box only protein 9 OS=Bos taurus GN=FBXO9 PE=2 SV=2 PF00646//PF00515//PF13181//PF13414//PF12937//PF03006 F-box domain//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//F-box-like//Haemolysin-III related -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2997 F-box protein FBX9 Cluster-8309.49007 BF_2 25.30 0.59 2084 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49009 BF_2 7.30 0.39 1070 808146256 XP_012174286.1 143 1.8e-06 PREDICTED: prestin [Bombus terrestris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49011 BF_2 120.39 2.62 2207 270000870 EEZ97317.1 1522 4.7e-166 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 46 2.67185e-12 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 226 3.7e-17 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 PF08476 Viral D10 N-terminal -- -- GO:0016791 phosphatase activity -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.49012 BF_2 365.65 5.63 3005 270000870 EEZ97317.1 1789 7.0e-197 hypothetical protein TcasGA2_TC011128 [Tribolium castaneum] 170036038 XM_001845821.1 95 2.10608e-39 Culex quinquefasciatus N-acetyl lactosaminide beta-1,3-N-acetyl glucosaminyl transferase, mRNA -- -- -- -- L7YAI7 274 1.4e-22 Beta-1,4-glucuronyltransferase 1 OS=Danio rerio GN=b4gat1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.49013 BF_2 260.99 1.94 5922 768446798 XP_011565358.1 1006 8.6e-106 PREDICTED: leucine-rich PPR motif-containing protein, mitochondrial-like [Plutella xylostella] 752871555 XM_011254679.1 92 1.94257e-37 PREDICTED: Camponotus floridanus 60S ribosome subunit biogenesis protein NIP7 homolog (LOC105249313), mRNA K07565 NIP7 60S ribosome subunit biogenesis protein NIP7 http://www.genome.jp/dbget-bin/www_bget?ko:K07565 Q503P2 684 7.7e-70 60S ribosome subunit biogenesis protein NIP7 homolog OS=Danio rerio GN=nip7 PE=2 SV=1 PF03002//PF13181//PF08686//PF03973//PF13176//PF04369//PF01472 Somatostatin/Cortistatin family//Tetratricopeptide repeat//PLAC (protease and lacunin) domain//Triabin//Tetratricopeptide repeat//Lactococcin-like family//PUA domain GO:0030682//GO:0042742//GO:0007165 evasion or tolerance of host defense response//defense response to bacterium//signal transduction GO:0008233//GO:0003723//GO:0005515//GO:0005179 peptidase activity//RNA binding//protein binding//hormone activity GO:0005576 extracellular region KOG3492 Ribosome biogenesis protein NIP7 Cluster-8309.49014 BF_2 809.45 11.92 3129 642916755 XP_008192481.1 2591 7.3e-290 PREDICTED: nuclear valosin-containing protein-like [Tribolium castaneum] 124087411 XM_001346809.1 35 4.95521e-06 Paramecium tetraurelia strain d4-2 >gnl|BL_ORD_ID|3811472 Paramecium tetraurelia hypothetical protein (GSPATT00000539001) partial mRNA K14571 RIX7, NVL ribosome biogenesis ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14571 O15381 1068 1.2e-114 Nuclear valosin-containing protein-like OS=Homo sapiens GN=NVL PE=1 SV=1 PF07726//PF00005//PF01637//PF01118//PF10662//PF00910//PF14532//PF06068//PF05496//PF01443//PF00437//PF07724//PF06414//PF02367//PF02562//PF00931//PF07728//PF01695//PF00158//PF01057//PF00004 ATPase family associated with various cellular activities (AAA)//ABC transporter//Archaeal ATPase//Semialdehyde dehydrogenase, NAD binding domain//Ethanolamine utilisation - propanediol utilisation//RNA helicase//Sigma-54 interaction domain//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//Viral (Superfamily 1) RNA helicase//Type II/IV secretion system protein//AAA domain (Cdc48 subfamily)//Zeta toxin//Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//NB-ARC domain//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//Parvovirus non-structural protein NS1//ATPase family associated with various cellular activities (AAA) GO:0006576//GO:0002949//GO:0006310//GO:0006810//GO:0006281//GO:0019079//GO:0055114//GO:0006355 cellular biogenic amine metabolic process//tRNA threonylcarbamoyladenosine modification//DNA recombination//transport//DNA repair//viral genome replication//oxidation-reduction process//regulation of transcription, DNA-templated GO:0051287//GO:0043531//GO:0003678//GO:0003723//GO:0009378//GO:0003724//GO:0008134//GO:0005524//GO:0016620//GO:0016301//GO:0016887 NAD binding//ADP binding//DNA helicase activity//RNA binding//four-way junction helicase activity//RNA helicase activity//transcription factor binding//ATP binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//kinase activity//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG0733 Nuclear AAA ATPase (VCP subfamily) Cluster-8309.49015 BF_2 7.00 1.53 478 642939494 XP_008190865.1 433 1.9e-40 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54FB7 179 2.2e-12 Xanthine dehydrogenase OS=Dictyostelium discoideum GN=xdh PE=3 SV=1 PF02738 Molybdopterin-binding domain of aldehyde dehydrogenase GO:0055114 oxidation-reduction process GO:0003824//GO:0043167//GO:0016491 catalytic activity//ion binding//oxidoreductase activity -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.49018 BF_2 37.00 2.45 920 642923341 XP_008193709.1 745 2.4e-76 PREDICTED: peptidyl-prolyl cis-trans isomerase-like [Tribolium castaneum] -- -- -- -- -- K03768 PPIB, ppiB peptidyl-prolyl cis-trans isomerase B (cyclophilin B) http://www.genome.jp/dbget-bin/www_bget?ko:K03768 P28517 548 7.0e-55 Peptidyl-prolyl cis-trans isomerase, rhodopsin-specific isozyme OS=Calliphora vicina GN=NINAA PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0880 Peptidyl-prolyl cis-trans isomerase Cluster-8309.49019 BF_2 223.64 4.72 2270 642910948 XP_008193477.1 2276 1.8e-253 PREDICTED: prolyl endopeptidase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01322 PREP prolyl oligopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01322 Q9QUR6 1570 5.4e-173 Prolyl endopeptidase OS=Mus musculus GN=Prep PE=2 SV=1 PF02897//PF00326 Prolyl oligopeptidase, N-terminal beta-propeller domain//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0070008//GO:0008236//GO:0004252 serine-type exopeptidase activity//serine-type peptidase activity//serine-type endopeptidase activity -- -- KOG2237 Predicted serine protease Cluster-8309.49021 BF_2 55.81 1.45 1894 642913668 XP_008201109.1 1299 2.9e-140 PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913670|ref|XP_008201110.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913672|ref|XP_008201111.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913674|ref|XP_008201112.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913676|ref|XP_008201113.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum]>gi|642913678|ref|XP_008201114.1| PREDICTED: solute carrier family 22 member 21 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WTW5 614 3.2e-62 Solute carrier family 22 member 3 OS=Mus musculus GN=Slc22a3 PE=2 SV=1 PF01272//PF07690//PF00083 Transcription elongation factor, GreA/GreB, C-term//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0032784 transmembrane transport//regulation of DNA-templated transcription, elongation GO:0003677//GO:0022857 DNA binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.49022 BF_2 126.60 1.17 4801 746863121 XP_011062509.1 3108 0.0e+00 PREDICTED: neither inactivation nor afterpotential protein C isoform X1 [Acromyrmex echinatior]>gi|746863123|ref|XP_011062510.1| PREDICTED: neither inactivation nor afterpotential protein C isoform X1 [Acromyrmex echinatior] -- -- -- -- -- K08834 MYO3, DFNB30 myosin III http://www.genome.jp/dbget-bin/www_bget?ko:K08834 P10676 2652 3.9e-298 Neither inactivation nor afterpotential protein C OS=Drosophila melanogaster GN=ninaC PE=1 SV=2 PF01991//PF07714//PF05337//PF00063//PF00612//PF06293//PF00069 ATP synthase (E/31 kDa) subunit//Protein tyrosine kinase//Macrophage colony stimulating factor-1 (CSF-1)//Myosin head (motor domain)//IQ calmodulin-binding motif//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0040007//GO:0015991//GO:0008283//GO:0006119//GO:0015992//GO:0007165//GO:0006468 growth//ATP hydrolysis coupled proton transport//cell proliferation//oxidative phosphorylation//proton transport//signal transduction//protein phosphorylation GO:0003774//GO:0016773//GO:0004672//GO:0008083//GO:0005515//GO:0005125//GO:0046961//GO:0005524 motor activity//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//growth factor activity//protein binding//cytokine activity//proton-transporting ATPase activity, rotational mechanism//ATP binding GO:0016020//GO:0016459//GO:0016021//GO:0033178 membrane//myosin complex//integral component of membrane//proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.49023 BF_2 233.50 6.78 1728 642916443 XP_008191029.1 1489 2.5e-162 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum]>gi|642916445|ref|XP_008191030.1| PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum] 572301862 XM_006616904.1 66 1.58734e-23 PREDICTED: Apis dorsata transmembrane and coiled-coil domains protein 2-like (LOC102681558), transcript variant X6, mRNA -- -- -- -- Q80W04 647 4.4e-66 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF00606//PF04513//PF08702//PF02601//PF02184//PF05073//PF03462//PF05478//PF05929//PF05531//PF07851 Herpesvirus Glycoprotein B//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//Exonuclease VII, large subunit//HAT (Half-A-TPR) repeat//Baculovirus P24 capsid protein//PCRF domain//Prominin//Phage capsid scaffolding protein (GPO) serine peptidase//Nucleopolyhedrovirus P10 protein//TMPIT-like protein GO:0030168//GO:0019069//GO:0006308//GO:0006449//GO:0006415//GO:0006396//GO:0007165//GO:0051258 platelet activation//viral capsid assembly//DNA catabolic process//regulation of translational termination//translational termination//RNA processing//signal transduction//protein polymerization GO:0030674//GO:0016149//GO:0008855//GO:0005102//GO:0005198 protein binding, bridging//translation release factor activity, codon specific//exodeoxyribonuclease VII activity//receptor binding//structural molecule activity GO:0016020//GO:0019031//GO:0005622//GO:0005840//GO:0009318//GO:0005737//GO:0005577//GO:0018444//GO:0019028//GO:0016021 membrane//viral envelope//intracellular//ribosome//exodeoxyribonuclease VII complex//cytoplasm//fibrinogen complex//translation release factor complex//viral capsid//integral component of membrane KOG3850 Predicted membrane protein Cluster-8309.49024 BF_2 78.25 0.49 6938 546674893 ERL86179.1 3041 0.0e+00 hypothetical protein D910_03592, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 2.07678e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1895 3.4e-210 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.49026 BF_2 165.55 5.18 1623 189241213 XP_970686.2 1339 5.7e-145 PREDICTED: peroxisomal targeting signal 1 receptor isoform X1 [Tribolium castaneum]>gi|270013260|gb|EFA09708.1| hypothetical protein TcasGA2_TC011841 [Tribolium castaneum] 462302391 APGK01050245.1 53 2.50913e-16 Dendroctonus ponderosae Seq01050255, whole genome shotgun sequence K13342 PEX5, PXR1 peroxin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K13342 P50542 635 1.0e-64 Peroxisomal targeting signal 1 receptor OS=Homo sapiens GN=PEX5 PE=1 SV=3 PF13414//PF13181//PF00515//PF13371 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1125 TPR repeat-containing protein Cluster-8309.49029 BF_2 79.26 0.68 5170 642926835 XP_008195033.1 610 6.2e-60 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S94 415 1.0e-38 Cyclin-L2 OS=Homo sapiens GN=CCNL2 PE=1 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355//GO:0006396//GO:0000079 regulation of transcription, DNA-templated//RNA processing//regulation of cyclin-dependent protein serine/threonine kinase activity GO:0019901//GO:0003700 protein kinase binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0834 CDK9 kinase-activating protein cyclin T Cluster-8309.49031 BF_2 48.00 3.13 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11023//PF03176//PF04987 Zinc-ribbon containing domain//MMPL family//Phosphatidylinositolglycan class N (PIG-N) GO:0006506 GPI anchor biosynthetic process GO:0016740 transferase activity GO:0005887//GO:0016020//GO:0005789 integral component of plasma membrane//membrane//endoplasmic reticulum membrane -- -- Cluster-8309.49033 BF_2 29.46 0.96 1566 546673667 ERL85231.1 1312 7.4e-142 hypothetical protein D910_02652 [Dendroctonus ponderosae] -- -- -- -- -- K06990 K06990 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06990 Q6GNT9 958 3.4e-102 Protein MEMO1 OS=Xenopus laevis GN=memo1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3086 Predicted dioxygenase Cluster-8309.49034 BF_2 161.21 1.29 5502 270009638 EFA06086.1 4231 0.0e+00 hypothetical protein TcasGA2_TC008923 [Tribolium castaneum] 817193412 XM_012416742.1 242 7.44193e-121 PREDICTED: Orussus abietinus unconventional myosin-VIIb-like (LOC105695296), transcript variant X2, mRNA -- -- -- -- Q8IVE3 343 2.5e-30 Pleckstrin homology domain-containing family H member 2 OS=Homo sapiens GN=PLEKHH2 PE=1 SV=2 PF02196//PF03359//PF00887//PF00784//PF08416//PF00788 Raf-like Ras-binding domain//Guanylate-kinase-associated protein (GKAP) protein//Acyl CoA binding protein//MyTH4 domain//Phosphotyrosine-binding domain//Ras association (RalGDS/AF-6) domain GO:0007165//GO:0023052 signal transduction//signaling GO:0000062//GO:0005057//GO:0005515 fatty-acyl-CoA binding//receptor signaling protein activity//protein binding GO:0005856 cytoskeleton KOG4229 Myosin VII, myosin IXB and related myosins Cluster-8309.49035 BF_2 229.01 5.31 2093 91091126 XP_969575.1 962 3.8e-101 PREDICTED: magnesium transporter NIPA2 [Tribolium castaneum]>gi|270013137|gb|EFA09585.1| hypothetical protein TcasGA2_TC011702 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SWX0 863 4.8e-91 Magnesium transporter NIPA2 OS=Bos taurus GN=NIPA2 PE=2 SV=1 PF05653//PF00892 Magnesium transporter NIPA//EamA-like transporter family GO:0015693 magnesium ion transport GO:0015095 magnesium ion transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2922 Uncharacterized conserved protein Cluster-8309.49037 BF_2 26.74 0.46 2713 91091126 XP_969575.1 384 5.2e-34 PREDICTED: magnesium transporter NIPA2 [Tribolium castaneum]>gi|270013137|gb|EFA09585.1| hypothetical protein TcasGA2_TC011702 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8Q9 350 1.9e-31 Magnesium transporter NIPA2 OS=Homo sapiens GN=NIPA2 PE=2 SV=1 PF00892//PF05653 EamA-like transporter family//Magnesium transporter NIPA GO:0015693 magnesium ion transport GO:0015095 magnesium ion transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2922 Uncharacterized conserved protein Cluster-8309.49040 BF_2 444.34 4.12 4800 91090806 XP_970749.1 4595 0.0e+00 PREDICTED: ubiquitin-protein ligase E3B [Tribolium castaneum]>gi|270013259|gb|EFA09707.1| hypothetical protein TcasGA2_TC011840 [Tribolium castaneum] 642935863 XM_965656.2 556 0 PREDICTED: Tribolium castaneum ubiquitin-protein ligase E3B (LOC659339), mRNA K10588 UBE3B ubiquitin-protein ligase E3 B http://www.genome.jp/dbget-bin/www_bget?ko:K10588 Q08CZ0 2754 5.8e-310 Ubiquitin-protein ligase E3B OS=Xenopus tropicalis GN=ube3b PE=2 SV=1 PF00632//PF00612 HECT-domain (ubiquitin-transferase)//IQ calmodulin-binding motif GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005622 intracellular KOG0942 E3 ubiquitin protein ligase Cluster-8309.49043 BF_2 159.00 10.77 905 91092040 XP_969867.1 628 8.9e-63 PREDICTED: probable phospholipid hydroperoxide glutathione peroxidase [Tribolium castaneum]>gi|270004921|gb|EFA01369.1| hypothetical protein TcasGA2_TC010354 [Tribolium castaneum] -- -- -- -- -- K05361 GPX4 phospholipid-hydroperoxide glutathione peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K05361 Q9LEF0 441 1.8e-42 Probable phospholipid hydroperoxide glutathione peroxidase OS=Mesembryanthemum crystallinum GN=GPXMC1 PE=2 SV=1 PF00578//PF08534//PF00255 AhpC/TSA family//Redoxin//Glutathione peroxidase GO:0055114//GO:0006804//GO:0006979//GO:0006749 oxidation-reduction process//obsolete peroxidase reaction//response to oxidative stress//glutathione metabolic process GO:0004602//GO:0016209//GO:0004601//GO:0016491 glutathione peroxidase activity//antioxidant activity//peroxidase activity//oxidoreductase activity -- -- KOG1651 Glutathione peroxidase Cluster-8309.49044 BF_2 860.00 36.49 1273 91087635 XP_973117.1 1195 2.2e-128 PREDICTED: proteasome subunit alpha type-5 [Tribolium castaneum]>gi|642930329|ref|XP_008196349.1| PREDICTED: proteasome subunit alpha type-5 [Tribolium castaneum]>gi|270009423|gb|EFA05871.1| hypothetical protein TcasGA2_TC008671 [Tribolium castaneum] 571526488 XM_006557223.1 230 7.90016e-115 PREDICTED: Apis mellifera proteasome alpha5 subunit (Prosalpha5), mRNA K02729 PSMA5 20S proteasome subunit alpha 5 http://www.genome.jp/dbget-bin/www_bget?ko:K02729 Q95083 984 2.7e-105 Proteasome subunit alpha type-5 OS=Drosophila melanogaster GN=Prosalpha5 PE=2 SV=2 PF00227//PF10584 Proteasome subunit//Proteasome subunit A N-terminal signature GO:0051603//GO:0006511 proteolysis involved in cellular protein catabolic process//ubiquitin-dependent protein catabolic process GO:0004298//GO:0004175 threonine-type endopeptidase activity//endopeptidase activity GO:0019773//GO:0005737//GO:0005839//GO:0005634 proteasome core complex, alpha-subunit complex//cytoplasm//proteasome core complex//nucleus KOG0176 20S proteasome, regulatory subunit alpha type PSMA5/PUP2 Cluster-8309.49046 BF_2 22.55 0.54 2019 642924856 XP_008194068.1 1494 7.6e-163 PREDICTED: trypsin-3 [Tribolium castaneum]>gi|270008121|gb|EFA04569.1| serine protease P133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P81286 420 1.1e-39 Plasminogen (Fragment) OS=Ovis aries GN=PLG PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.49047 BF_2 95.70 0.62 6755 546676860 ERL87797.1 1674 3.4e-183 hypothetical protein D910_05186 [Dendroctonus ponderosae] 512862182 XM_002935331.2 57 6.33947e-18 PREDICTED: Xenopus (Silurana) tropicalis enhancer of rudimentary homolog (Drosophila) (erh), mRNA -- -- -- -- Q8NBJ9 1125 6.4e-121 SID1 transmembrane family member 2 OS=Homo sapiens GN=SIDT2 PE=1 SV=2 PF08030//PF01133//PF00097//PF00175//PF13965 Ferric reductase NAD binding domain//Enhancer of rudimentary//Zinc finger, C3HC4 type (RING finger)//Oxidoreductase NAD-binding domain//dsRNA-gated channel SID-1 GO:0045747//GO:0015931//GO:0006221//GO:0033227//GO:0007049//GO:0055114 positive regulation of Notch signaling pathway//nucleobase-containing compound transport//pyrimidine nucleotide biosynthetic process//dsRNA transport//cell cycle//oxidation-reduction process GO:0016491//GO:0046872//GO:0051033 oxidoreductase activity//metal ion binding//RNA transmembrane transporter activity GO:0016021 integral component of membrane KOG1766 Enhancer of rudimentary Cluster-8309.49048 BF_2 578.76 4.43 5757 546682075 ERL92061.1 4429 0.0e+00 hypothetical protein D910_09383 [Dendroctonus ponderosae] -- -- -- -- -- K06101 ASH1L histone-lysine N-methyltransferase ASH1L http://www.genome.jp/dbget-bin/www_bget?ko:K06101 Q9VW15 2095 1.8e-233 Histone-lysine N-methyltransferase ash1 OS=Drosophila melanogaster GN=ash1 PE=1 SV=3 PF00439//PF00856//PF01426//PF02378//PF00628 Bromodomain//SET domain//BAH domain//Phosphotransferase system, EIIC//PHD-finger GO:0009401//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//carbohydrate transport GO:0005515//GO:0008982//GO:0003682 protein binding//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//chromatin binding GO:0000785//GO:0009357//GO:0016020 chromatin//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.49051 BF_2 69.47 0.38 7850 642935646 XP_008198097.1 2678 1.5e-299 PREDICTED: rho GTPase-activating protein 21-B isoform X6 [Tribolium castaneum] 642935645 XM_008199875.1 247 1.7669e-123 PREDICTED: Tribolium castaneum rho GTPase-activating protein 21-B (LOC663411), transcript variant X6, mRNA -- -- -- -- Q71M21 793 2.3e-82 Rho GTPase-activating protein 21-B OS=Xenopus laevis GN=arhgap21-b PE=2 SV=1 PF08718//PF11973//PF13180//PF00595//PF00620 Glycolipid transfer protein (GLTP)//NQRA C-terminal domain//PDZ domain//PDZ domain (Also known as DHR or GLGF)//RhoGAP domain GO:0055114//GO:0006118//GO:0046836//GO:0007165 oxidation-reduction process//obsolete electron transport//glycolipid transport//signal transduction GO:0016655//GO:0051861//GO:0005515//GO:0017089 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//glycolipid binding//protein binding//glycolipid transporter activity GO:0005737 cytoplasm KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.49052 BF_2 9.17 0.33 1437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17056 Killer toxin-resistance protein 1 GO:0031505 fungal-type cell wall organization -- -- -- -- -- -- Cluster-8309.49053 BF_2 183.00 4.75 1898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49055 BF_2 262.00 2.53 4611 478256707 ENN76889.1 1972 6.5e-218 hypothetical protein YQE_06730, partial [Dendroctonus ponderosae]>gi|546685095|gb|ERL94622.1| hypothetical protein D910_11898 [Dendroctonus ponderosae] 880935623 XM_005079858.2 48 4.34923e-13 PREDICTED: Mesocricetus auratus dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 (Dyrk3), mRNA K18669 DYRK2_3_4 dual specificity tyrosine-phosphorylation-regulated kinase 2/3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K18669 Q5ZIU3 1711 4.9e-189 Dual specificity tyrosine-phosphorylation-regulated kinase 2 OS=Gallus gallus GN=DYRK2 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0667 Dual-specificity tyrosine-phosphorylation regulated kinase Cluster-8309.49057 BF_2 177.00 4.97 1777 642911746 XP_008200724.1 1659 4.9e-182 PREDICTED: protein MON2 homolog isoform X2 [Tribolium castaneum] 462386069 APGK01020363.1 46 2.14289e-12 Dendroctonus ponderosae Seq01020373, whole genome shotgun sequence -- -- -- -- Q9VLT1 1223 7.3e-133 Protein MON2 homolog OS=Drosophila melanogaster GN=mon2 PE=2 SV=4 PF07464 Apolipophorin-III precursor (apoLp-III) GO:0006869 lipid transport GO:0008289 lipid binding GO:0005576 extracellular region KOG1848 Uncharacterized conserved protein Cluster-8309.49058 BF_2 746.00 7.60 4395 642911744 XP_008200722.1 5379 0.0e+00 PREDICTED: protein MON2 homolog isoform X1 [Tribolium castaneum]>gi|270014560|gb|EFA11008.1| hypothetical protein TcasGA2_TC004594 [Tribolium castaneum] 805783467 XM_012284434.1 38 1.50099e-07 PREDICTED: Megachile rotundata protein MON2 homolog (LOC100878853), transcript variant X3, mRNA -- -- -- -- Q9VLT1 3816 0.0e+00 Protein MON2 homolog OS=Drosophila melanogaster GN=mon2 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG1848 Uncharacterized conserved protein Cluster-8309.49060 BF_2 57.78 0.97 2775 642918280 XP_008191442.1 388 1.8e-34 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] -- -- -- -- -- K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P81436 371 7.1e-34 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Oryctolagus cuniculus GN=OGT PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.49061 BF_2 49.32 0.32 6715 91091178 XP_971714.1 1911 1.1e-210 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936379|ref|XP_008198413.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936381|ref|XP_008198414.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|642936384|ref|XP_008198415.1| PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270013121|gb|EFA09569.1| hypothetical protein TcasGA2_TC011683 [Tribolium castaneum] 564254995 XM_006266415.1 37 8.26795e-07 PREDICTED: Alligator mississippiensis F-box protein 21 (FBXO21), mRNA K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q9EPL9 1219 8.0e-132 Peroxisomal acyl-coenzyme A oxidase 3 OS=Mus musculus GN=Acox3 PE=1 SV=2 PF00646//PF00213//PF01756//PF08755//PF00441//PF02770//PF12937 F-box domain//ATP synthase delta (OSCP) subunit//Acyl-CoA oxidase//Hemimethylated DNA-binding protein YccV like//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//F-box-like GO:0006635//GO:0006637//GO:0055114//GO:0006118//GO:0006631//GO:0015986 fatty acid beta-oxidation//acyl-CoA metabolic process//oxidation-reduction process//obsolete electron transport//fatty acid metabolic process//ATP synthesis coupled proton transport GO:0005515//GO:0003995//GO:0003677//GO:0016627//GO:0046933//GO:0003997 protein binding//acyl-CoA dehydrogenase activity//DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//proton-transporting ATP synthase activity, rotational mechanism//acyl-CoA oxidase activity GO:0005777//GO:0045259 peroxisome//proton-transporting ATP synthase complex KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.49062 BF_2 5.00 0.51 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49066 BF_2 604.76 19.01 1618 642929822 XP_975593.2 1060 1.3e-112 PREDICTED: pleckstrin homology domain-containing family F member 2 [Tribolium castaneum] 755945962 XM_011301681.1 108 6.66535e-47 PREDICTED: Fopius arisanus pleckstrin homology domain-containing family F member 2 (LOC105264662), mRNA -- -- -- -- Q91WB4 815 1.4e-85 Pleckstrin homology domain-containing family F member 2 OS=Mus musculus GN=Plekhf2 PE=1 SV=1 PF01363 FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- KOG1729 FYVE finger containing protein Cluster-8309.49069 BF_2 2.00 3.83 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49070 BF_2 638.00 6.17 4616 189233723 XP_970246.2 2880 0.0e+00 PREDICTED: leishmanolysin-like peptidase [Tribolium castaneum] 807037579 XM_004533605.2 92 1.51155e-37 PREDICTED: Ceratitis capitata leishmanolysin-like peptidase (LOC101450918), transcript variant X4, mRNA K13539 LMLN leishmanolysin-like peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K13539 Q29AK2 2313 7.6e-259 Leishmanolysin-like peptidase OS=Drosophila pseudoobscura pseudoobscura GN=GA17800 PE=3 SV=1 PF03491//PF01457 Serotonin (5-HT) neurotransmitter transporter, N-terminus//Leishmanolysin GO:0006508//GO:0006812//GO:0007155//GO:0006836 proteolysis//cation transport//cell adhesion//neurotransmitter transport GO:0005335//GO:0004222 serotonin:sodium symporter activity//metalloendopeptidase activity GO:0016020//GO:0005887 membrane//integral component of plasma membrane KOG2556 Leishmanolysin-like peptidase (Peptidase M8 family) Cluster-8309.49071 BF_2 403.05 3.71 4834 189240517 XP_001812287.1 5551 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X1 [Tribolium castaneum]>gi|270012592|gb|EFA09040.1| hypothetical protein TcasGA2_TC006753 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49072 BF_2 250.39 2.66 4222 642933365 XP_008197385.1 5115 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49073 BF_2 138.51 1.25 4934 189240517 XP_001812287.1 3876 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X1 [Tribolium castaneum]>gi|270012592|gb|EFA09040.1| hypothetical protein TcasGA2_TC006753 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49074 BF_2 170.76 1.60 4762 642933365 XP_008197385.1 5446 0.0e+00 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15202 Adipogenin GO:0045444 fat cell differentiation -- -- -- -- -- -- Cluster-8309.49075 BF_2 5.04 0.41 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49076 BF_2 3774.43 59.29 2950 642924301 XP_008194238.1 3160 0.0e+00 PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924303|ref|XP_008194239.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum]>gi|642924305|ref|XP_008194240.1| PREDICTED: glycerol-3-phosphate dehydrogenase, mitochondrial isoform X1 [Tribolium castaneum] -- -- -- -- -- K00111 glpA, glpD glycerol-3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00111 A6QLU1 2199 8.1e-246 Glycerol-3-phosphate dehydrogenase, mitochondrial OS=Bos taurus GN=GPD2 PE=2 SV=1 PF12831//PF13202//PF00036//PF07992//PF01134//PF13405//PF13833//PF01266//PF13499 FAD dependent oxidoreductase//EF hand//EF hand//Pyridine nucleotide-disulphide oxidoreductase//Glucose inhibited division protein A//EF-hand domain//EF-hand domain pair//FAD dependent oxidoreductase//EF-hand domain pair GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0005509//GO:0050660//GO:0016491 calcium ion binding//flavin adenine dinucleotide binding//oxidoreductase activity -- -- KOG0042 Glycerol-3-phosphate dehydrogenase Cluster-8309.49077 BF_2 16.61 0.34 2306 91078242 XP_970298.1 1646 2.0e-180 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 462322709 APGK01042728.1 101 7.44453e-43 Dendroctonus ponderosae Seq01042738, whole genome shotgun sequence K00921 PIKFYVE, FAB1 1-phosphatidylinositol-3-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00921 Q9Z1T6 577 7.6e-58 1-phosphatidylinositol 3-phosphate 5-kinase OS=Mus musculus GN=Pikfyve PE=1 SV=3 PF00118//PF00851//PF00610//PF01363 TCP-1/cpn60 chaperonin family//Helper component proteinase//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//FYVE zinc finger GO:0046488//GO:0006508//GO:0035556 phosphatidylinositol metabolic process//proteolysis//intracellular signal transduction GO:0043167//GO:0005524//GO:0004197//GO:0046872 ion binding//ATP binding//cysteine-type endopeptidase activity//metal ion binding -- -- KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.49080 BF_2 181.12 1.39 5738 270014299 EFA10747.1 1625 1.4e-177 hypothetical protein TcasGA2_TC012493 [Tribolium castaneum]>gi|485836784|tpg|DAA64479.1| TPA_inf: ETH-like G protein-coupled receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O93603 396 1.8e-36 Thyrotropin-releasing hormone receptor OS=Gallus gallus GN=TRHR PE=2 SV=1 PF07057//PF05924//PF00001//PF01278 DNA helicase TraI//SAMP Motif//7 transmembrane receptor (rhodopsin family)//Omptin family GO:0000746//GO:0007186//GO:0006508//GO:0016055 conjugation//G-protein coupled receptor signaling pathway//proteolysis//Wnt signaling pathway GO:0016818//GO:0008013//GO:0004175//GO:0003678//GO:0005524//GO:0003677//GO:0004930 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//beta-catenin binding//endopeptidase activity//DNA helicase activity//ATP binding//DNA binding//G-protein coupled receptor activity GO:0016342//GO:0009279//GO:0005657//GO:0016021 catenin complex//cell outer membrane//replication fork//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.49082 BF_2 7.00 0.41 996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49083 BF_2 92.01 1.15 3621 642916443 XP_008191029.1 1482 3.3e-161 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum]>gi|642916445|ref|XP_008191030.1| PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W04 670 2.0e-68 Transmembrane and coiled-coil domains protein 2 OS=Mus musculus GN=Tmcc2 PE=1 SV=1 PF02601//PF00038//PF08702//PF04513//PF02184//PF03462//PF05073//PF05531//PF07851//PF10459//PF05929//PF05478 Exonuclease VII, large subunit//Intermediate filament protein//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//HAT (Half-A-TPR) repeat//PCRF domain//Baculovirus P24 capsid protein//Nucleopolyhedrovirus P10 protein//TMPIT-like protein//Peptidase S46//Phage capsid scaffolding protein (GPO) serine peptidase//Prominin GO:0007165//GO:0051258//GO:0006415//GO:0006396//GO:0006449//GO:0030168//GO:0006308//GO:0019069 signal transduction//protein polymerization//translational termination//RNA processing//regulation of translational termination//platelet activation//DNA catabolic process//viral capsid assembly GO:0005198//GO:0070009//GO:0005102//GO:0016149//GO:0008855//GO:0030674//GO:0008239 structural molecule activity//serine-type aminopeptidase activity//receptor binding//translation release factor activity, codon specific//exodeoxyribonuclease VII activity//protein binding, bridging//dipeptidyl-peptidase activity GO:0016021//GO:0019028//GO:0005882//GO:0005622//GO:0009318//GO:0005840//GO:0005577//GO:0005737//GO:0018444//GO:0019031 integral component of membrane//viral capsid//intermediate filament//intracellular//exodeoxyribonuclease VII complex//ribosome//fibrinogen complex//cytoplasm//translation release factor complex//viral envelope KOG3850 Predicted membrane protein Cluster-8309.49089 BF_2 180.30 1.15 6822 642937838 XP_008200322.1 3064 0.0e+00 PREDICTED: tyrosine-protein kinase Fps85D isoform X1 [Tribolium castaneum]>gi|270000733|gb|EEZ97180.1| hypothetical protein TcasGA2_TC004367 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1537 1.1e-168 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF09432//PF10541//PF07714//PF05090//PF00069//PF00346 Tho complex subunit THP2//Nuclear envelope localisation domain//Protein tyrosine kinase//Vitamin K-dependent gamma-carboxylase//Protein kinase domain//Respiratory-chain NADH dehydrogenase, 49 Kd subunit GO:0006468//GO:0017187//GO:0006406//GO:0006368//GO:0055114 protein phosphorylation//peptidyl-glutamic acid carboxylation//mRNA export from nucleus//transcription elongation from RNA polymerase II promoter//oxidation-reduction process GO:0051287//GO:0016651//GO:0004713//GO:0005524//GO:0048038//GO:0004672//GO:0008488 NAD binding//oxidoreductase activity, acting on NAD(P)H//protein tyrosine kinase activity//ATP binding//quinone binding//protein kinase activity//gamma-glutamyl carboxylase activity GO:0016021//GO:0000446 integral component of membrane//nucleoplasmic THO complex KOG0194 Protein tyrosine kinase Cluster-8309.49090 BF_2 404.79 7.36 2587 91094503 XP_971555.1 1921 3.0e-212 PREDICTED: tyrosine-protein kinase Fps85D isoform X2 [Tribolium castaneum] -- -- -- -- -- K08889 FER, TYK3 tyrosine-protein kinase Fer http://www.genome.jp/dbget-bin/www_bget?ko:K08889 P18106 1546 3.7e-170 Tyrosine-protein kinase Fps85D OS=Drosophila melanogaster GN=Fps85D PE=2 SV=3 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0194 Protein tyrosine kinase Cluster-8309.49092 BF_2 19.32 1.05 1059 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49093 BF_2 23.00 0.82 1464 646703486 KDR12134.1 1228 3.8e-132 Membrane-bound alkaline phosphatase [Zootermopsis nevadensis] 557753920 XM_005176648.1 43 8.17852e-11 PREDICTED: Musca domestica membrane-bound alkaline phosphatase (LOC101888689), mRNA K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 P29523 1010 3.0e-108 Membrane-bound alkaline phosphatase OS=Bombyx mori GN=Alp-m PE=1 SV=4 PF00245//PF02533//PF01676 Alkaline phosphatase//Photosystem II 4 kDa reaction centre component//Metalloenzyme superfamily GO:0015979//GO:0008152 photosynthesis//metabolic process GO:0046872//GO:0016791//GO:0003824 metal ion binding//phosphatase activity//catalytic activity GO:0009539//GO:0009523 photosystem II reaction center//photosystem II -- -- Cluster-8309.49097 BF_2 44.08 0.70 2907 642927136 XP_972282.2 1000 2.1e-105 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6QHF9 273 1.7e-22 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593//PF00858 Flavin containing amine oxidoreductase//Amiloride-sensitive sodium channel GO:0006814//GO:0055114 sodium ion transport//oxidation-reduction process GO:0005272//GO:0016491 sodium channel activity//oxidoreductase activity GO:0016020 membrane KOG0685 Flavin-containing amine oxidase Cluster-8309.49101 BF_2 25.20 0.85 1523 642936884 XP_969823.3 427 3.0e-39 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 195 9.9e-14 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49102 BF_2 15.18 0.97 945 270001017 EEZ97464.1 326 9.7e-28 hypothetical protein TcasGA2_TC011295 [Tribolium castaneum] -- -- -- -- -- K13194 ADARB double stranded RNA-specific editase B http://www.genome.jp/dbget-bin/www_bget?ko:K13194 Q9NII1 247 5.8e-20 Double-stranded RNA-specific editase Adar OS=Drosophila melanogaster GN=Adar PE=1 SV=2 PF02137 Adenosine-deaminase (editase) domain GO:0006144//GO:0006807//GO:0006396 purine nucleobase metabolic process//nitrogen compound metabolic process//RNA processing GO:0003723//GO:0004000 RNA binding//adenosine deaminase activity -- -- KOG2777 tRNA-specific adenosine deaminase 1 Cluster-8309.49104 BF_2 564.67 9.34 2815 805765285 XP_012134962.1 832 6.1e-86 PREDICTED: peptidyl-prolyl cis-trans isomerase cyp11 isoform X2 [Megachile rotundata] 645259408 XM_008237125.1 62 4.35866e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.1e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.49105 BF_2 16.12 0.58 1456 478250783 ENN71275.1 592 2.1e-58 hypothetical protein YQE_12200, partial [Dendroctonus ponderosae]>gi|546673018|gb|ERL84704.1| hypothetical protein D910_02129 [Dendroctonus ponderosae] -- -- -- -- -- K06999 K06999 phospholipase/carboxylesterase http://www.genome.jp/dbget-bin/www_bget?ko:K06999 Q3UFF7 359 9.1e-33 Lysophospholipase-like protein 1 OS=Mus musculus GN=Lyplal1 PE=1 SV=3 PF03583//PF01738//PF01764//PF07859//PF02230//PF00326 Secretory lipase//Dienelactone hydrolase family//Lipase (class 3)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family GO:0008152//GO:0006629//GO:0016042//GO:0006508//GO:0046486 metabolic process//lipid metabolic process//lipid catabolic process//proteolysis//glycerolipid metabolic process GO:0016787//GO:0004806//GO:0008236 hydrolase activity//triglyceride lipase activity//serine-type peptidase activity -- -- KOG2112 Lysophospholipase Cluster-8309.49106 BF_2 148.64 0.83 7816 123407101 XP_001302933.1 225 4.1e-15 hypothetical protein [Trichomonas vaginalis G3]>gi|121884268|gb|EAX90003.1| hypothetical protein TVAG_272650 [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q54PM6 146 2.5e-07 Uncharacterized protein DDB_G0284459 OS=Dictyostelium discoideum GN=DDB_G0284459 PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49107 BF_2 50.00 1.45 1732 478257465 ENN77621.1 438 1.8e-40 hypothetical protein YQE_05915, partial [Dendroctonus ponderosae]>gi|546679859|gb|ERL90247.1| hypothetical protein D910_07599 [Dendroctonus ponderosae] 665389295 NM_001297885.1 50 1.24752e-14 Drosophila melanogaster vinculin (Vinc), transcript variant C, mRNA K05700 VCL vinculin http://www.genome.jp/dbget-bin/www_bget?ko:K05700 O46037 359 1.1e-32 Vinculin OS=Drosophila melanogaster GN=Vinc PE=1 SV=1 PF01044//PF01608 Vinculin family//I/LWEQ domain GO:0007155 cell adhesion GO:0003779//GO:0051015 actin binding//actin filament binding -- -- KOG3681 Alpha-catenin Cluster-8309.49108 BF_2 4.00 36.05 236 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49109 BF_2 19.88 4.04 493 270005102 EFA01550.1 399 1.7e-36 hypothetical protein TcasGA2_TC007111 [Tribolium castaneum] -- -- -- -- -- K17602 YLPM1 YLP motif-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17602 Q9R0I7 193 5.5e-14 YLP motif-containing protein 1 OS=Mus musculus GN=Ylpm1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49110 BF_2 173.79 1.57 4917 728417025 AIY68331.1 3330 0.0e+00 putative gliotactin [Leptinotarsa decemlineata] 645019941 XM_008208782.1 54 2.14363e-16 PREDICTED: Nasonia vitripennis gliotactin (LOC100120557), transcript variant X3, mRNA -- -- -- -- Q8NFZ3 621 1.3e-62 Neuroligin-4, Y-linked OS=Homo sapiens GN=NLGN4Y PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.49111 BF_2 16.61 0.34 2303 91084545 XP_973071.1 1808 3.4e-199 PREDICTED: tudor domain-containing protein 7 isoform X1 [Tribolium castaneum]>gi|270008665|gb|EFA05113.1| hypothetical protein TcasGA2_TC015214 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.0e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49113 BF_2 4.00 2.24 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49114 BF_2 7.00 0.90 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49121 BF_2 4.59 0.39 777 357608515 EHJ66045.1 277 3.8e-22 hypothetical protein KGM_18750 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49122 BF_2 77.57 2.64 1518 795021508 XP_011860288.1 1161 2.3e-124 PREDICTED: putative uncharacterized protein FLJ37770 [Vollenhovia emeryi] 795018260 XM_012003757.1 984 0 PREDICTED: Vollenhovia emeryi putative uncharacterized protein FLJ37770 (LOC105556663), mRNA -- -- -- -- Q7JQ07 340 1.5e-30 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF07778 Mis6 GO:0034508 centromere complex assembly -- -- GO:0000776 kinetochore -- -- Cluster-8309.49124 BF_2 13.05 0.34 1910 642928186 XP_008195482.1 864 8.1e-90 PREDICTED: retinol dehydrogenase 12-like [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8NBN7 567 9.1e-57 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF01370//PF00106 NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- -- -- Cluster-8309.49125 BF_2 146.64 2.01 3345 642934172 XP_969292.2 1255 6.5e-135 PREDICTED: ras-related protein Rab-3 isoform X1 [Tribolium castaneum] 242004796 XM_002423218.1 218 9.89098e-108 Pediculus humanus corporis RAB 3 and, putative, mRNA K07883 RAB3C Ras-related protein Rab-3C http://www.genome.jp/dbget-bin/www_bget?ko:K07883 P25228 1074 2.6e-115 Ras-related protein Rab-3 OS=Drosophila melanogaster GN=Rab3 PE=1 SV=1 PF04451//PF03193//PF04670//PF00071//PF00503//PF01926//PF08477//PF00025//PF02421 Large eukaryotic DNA virus major capsid protein//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//G-protein alpha subunit//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ferrous iron transport protein B GO:0007165//GO:0007264//GO:0015684//GO:0007186 signal transduction//small GTPase mediated signal transduction//ferrous iron transport//G-protein coupled receptor signaling pathway GO:0005198//GO:0003924//GO:0015093//GO:0031683//GO:0005525//GO:0019001//GO:0004871 structural molecule activity//GTPase activity//ferrous iron transmembrane transporter activity//G-protein beta/gamma-subunit complex binding//GTP binding//guanyl nucleotide binding//signal transducer activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.49131 BF_2 791.78 9.09 3931 642910295 XP_008200272.1 1711 1.0e-187 PREDICTED: beta-N-acetylglucosaminidase NAG2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00827 AGXT2 alanine-glyoxylate transaminase / (R)-3-amino-2-methylpropionate-pyruvate transaminase http://www.genome.jp/dbget-bin/www_bget?ko:K00827 Q9BYV1 1306 3.8e-142 Alanine--glyoxylate aminotransferase 2, mitochondrial OS=Homo sapiens GN=AGXT2 PE=1 SV=1 PF00728//PF00202//PF00155 Glycosyl hydrolase family 20, catalytic domain//Aminotransferase class-III//Aminotransferase class I and II GO:0009058//GO:0005975 biosynthetic process//carbohydrate metabolic process GO:0030170//GO:0008483//GO:0004553 pyridoxal phosphate binding//transaminase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.49135 BF_2 31.65 0.31 4533 91078312 XP_972704.1 2673 3.3e-299 PREDICTED: intraflagellar transport protein 122 homolog [Tribolium castaneum]>gi|270003955|gb|EFA00403.1| hypothetical protein TcasGA2_TC003254 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NWV3 1958 1.1e-217 Intraflagellar transport protein 122 homolog OS=Mus musculus GN=Ift122 PE=2 SV=1 PF13181//PF01525//PF00400//PF01363//PF04053//PF13639//PF00637//PF13176 Tetratricopeptide repeat//Rotavirus NS26//WD domain, G-beta repeat//FYVE zinc finger//Coatomer WD associated region//Ring finger domain//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0019079//GO:0006886//GO:0016192 viral genome replication//intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198//GO:0016887//GO:0008270//GO:0046872//GO:0000287 protein binding//structural molecule activity//ATPase activity//zinc ion binding//metal ion binding//magnesium ion binding GO:0030430//GO:0030117 host cell cytoplasm//membrane coat KOG1538 Uncharacterized conserved protein WDR10, contains WD40 repeats Cluster-8309.49136 BF_2 531.69 8.19 3002 642921429 XP_974248.2 1678 5.2e-184 PREDICTED: uncharacterized protein LOC663094 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4KMD7 284 9.4e-24 Speckle targeted PIP5K1A-regulated poly(A) polymerase OS=Danio rerio GN=tut1 PE=2 SV=1 PF01909//PF08039//PF09128 Nucleotidyltransferase domain//Mitochondrial proteolipid//Regulator of G protein signalling-like domain GO:0043087 regulation of GTPase activity GO:0005089//GO:0016779 Rho guanyl-nucleotide exchange factor activity//nucleotidyltransferase activity GO:0005737//GO:0005739 cytoplasm//mitochondrion KOG2277 S-M checkpoint control protein CID1 and related nucleotidyltransferases Cluster-8309.49138 BF_2 119.01 1.12 4717 478260065 ENN79850.1 406 2.6e-36 hypothetical protein YQE_03670, partial [Dendroctonus ponderosae]>gi|546676798|gb|ERL87744.1| hypothetical protein D910_05133, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:0030431//GO:1903818//GO:0032222//GO:0007178//GO:0016310//GO:0009069 sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic//transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.4914 BF_2 2.00 1.06 363 795009010 XP_011859826.1 294 1.9e-24 PREDICTED: uncharacterized protein LOC105557250, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07531 NHR1 homology to TAF GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.49140 BF_2 250.16 2.48 4509 478260065 ENN79850.1 406 2.4e-36 hypothetical protein YQE_03670, partial [Dendroctonus ponderosae]>gi|546676798|gb|ERL87744.1| hypothetical protein D910_05133, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01064//PF17064 Activin types I and II receptor domain//Sleepless protein GO:1903818//GO:0030431//GO:0032222//GO:0016310//GO:0009069//GO:0007178 positive regulation of voltage-gated potassium channel activity//sleep//regulation of synaptic transmission, cholinergic//phosphorylation//serine family amino acid metabolic process//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0004675//GO:0034235 transmembrane receptor protein serine/threonine kinase activity//GPI anchor binding GO:0016020 membrane -- -- Cluster-8309.49141 BF_2 71.75 1.86 1904 546673729 ERL85285.1 1122 9.7e-120 hypothetical protein D910_02706 [Dendroctonus ponderosae] -- -- -- -- -- K10812 GlcAT-SP beta-1,3-glucuronyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10812 Q9VTG7 854 4.8e-90 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P OS=Drosophila melanogaster GN=GlcAT-P PE=2 SV=1 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.49142 BF_2 52.38 1.50 1750 546673729 ERL85285.1 1122 9.0e-120 hypothetical protein D910_02706 [Dendroctonus ponderosae] -- -- -- -- -- K10812 GlcAT-SP beta-1,3-glucuronyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K10812 Q9VTG7 854 4.4e-90 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase P OS=Drosophila melanogaster GN=GlcAT-P PE=2 SV=1 PF03360 Glycosyltransferase family 43 GO:0030206 chondroitin sulfate biosynthetic process GO:0015018 galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity GO:0016020 membrane KOG1476 Beta-1,3-glucuronyltransferase B3GAT1/SQV-8 Cluster-8309.49145 BF_2 50.02 1.23 1985 546673062 ERL84739.1 806 4.5e-83 hypothetical protein D910_02164 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q6AYT7 361 7.3e-33 Monoacylglycerol lipase ABHD12 OS=Rattus norvegicus GN=Abhd12 PE=2 SV=1 PF11112//PF01764//PF07859//PF10503 Pyocin activator protein PrtN//Lipase (class 3)//alpha/beta hydrolase fold//Esterase PHB depolymerase GO:0008152//GO:0006355//GO:0006629 metabolic process//regulation of transcription, DNA-templated//lipid metabolic process GO:0016787 hydrolase activity GO:0005576 extracellular region -- -- Cluster-8309.49149 BF_2 102.20 5.25 1101 642919346 XP_008191834.1 536 5.0e-52 PREDICTED: uncharacterized protein LOC662079 [Tribolium castaneum]>gi|270005802|gb|EFA02250.1| hypothetical protein TcasGA2_TC007913 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690//PF05425 Major Facilitator Superfamily//Copper resistance protein D GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49152 BF_2 562.26 3.82 6437 91077834 XP_971265.1 7175 0.0e+00 PREDICTED: integrator complex subunit 1 [Tribolium castaneum]>gi|270002256|gb|EEZ98703.1| hypothetical protein TcasGA2_TC001242 [Tribolium castaneum] -- -- -- -- -- K13138 INTS1 integrator complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13138 Q6P4S8 2384 6.2e-267 Integrator complex subunit 1 OS=Mus musculus GN=Ints1 PE=2 SV=2 PF04443 Acyl-protein synthetase, LuxE GO:0008218 bioluminescence GO:0047474 long-chain fatty acid luciferin component ligase activity -- -- -- -- Cluster-8309.49154 BF_2 68.05 1.42 2292 91090216 XP_968004.1 1600 4.4e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.7e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008146//GO:0008476 sulfotransferase activity//protein-tyrosine sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.49155 BF_2 89.24 3.23 1443 642922884 XP_008200437.1 1527 8.1e-167 PREDICTED: uncharacterized protein LOC659493 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49157 BF_2 104.07 0.92 5016 642922889 XP_008200440.1 1532 7.4e-167 PREDICTED: uncharacterized protein LOC659493 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49158 BF_2 155.00 4.63 1689 91094819 XP_970889.1 1558 2.4e-170 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49159 BF_2 223.13 1.86 5313 91094819 XP_970889.1 1558 7.6e-170 PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|642922887|ref|XP_008200438.1| PREDICTED: uncharacterized protein LOC659493 isoform X2 [Tribolium castaneum]>gi|270006570|gb|EFA03018.1| hypothetical protein TcasGA2_TC010441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49160 BF_2 229.12 2.27 4507 189236906 XP_001809986.1 2851 0.0e+00 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 1480 2.9e-162 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF00140//PF00023//PF13606//PF01529 Sigma-70 factor, region 1.2//Ankyrin repeat//Ankyrin repeat//DHHC palmitoyltransferase GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003677//GO:0005515//GO:0008270//GO:0016987//GO:0003700//GO:0046872 DNA binding//protein binding//zinc ion binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667 transcription factor complex KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.49161 BF_2 2240.00 93.16 1293 227018332 ACP18832.1 818 1.2e-84 tetraspanin 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P08962 286 2.4e-24 CD63 antigen OS=Homo sapiens GN=CD63 PE=1 SV=2 PF00335//PF03600 Tetraspanin family//Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49165 BF_2 163.02 5.56 1513 642934075 XP_008196143.1 1076 1.7e-114 PREDICTED: sin3 histone deacetylase corepressor complex component SDS3 [Tribolium castaneum]>gi|270012950|gb|EFA09398.1| hypothetical protein TcasGA2_TC004316 [Tribolium castaneum] 347964404 XM_559379.4 34 8.51902e-06 Anopheles gambiae str. PEST AGAP000738-PA (AgaP_AGAP000738) mRNA, complete cds K19201 SUDS3, SAP45 Sin3 histone deacetylase corepressor complex component SDS3 http://www.genome.jp/dbget-bin/www_bget?ko:K19201 Q5RBB8 633 1.6e-64 Sin3 histone deacetylase corepressor complex component SDS3 OS=Pongo abelii GN=SUDS3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49166 BF_2 30.29 0.59 2446 189236145 XP_974763.2 2325 4.0e-259 PREDICTED: diphthine--ammonia ligase [Tribolium castaneum]>gi|270005602|gb|EFA02050.1| hypothetical protein TcasGA2_TC007678 [Tribolium castaneum] -- -- -- -- -- K06927 DPH6 diphthine-ammonia ligase http://www.genome.jp/dbget-bin/www_bget?ko:K06927 Q9USQ7 917 3.0e-97 Diphthine--ammonia ligase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=mug71 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2316 Predicted ATPase (PP-loop superfamily) Cluster-8309.49167 BF_2 79.36 0.59 5933 478255012 ENN75245.1 1054 2.3e-111 hypothetical protein YQE_08254, partial [Dendroctonus ponderosae] -- -- -- -- -- K10684 UBLE1A, SAE1 ubiquitin-like 1-activating enzyme E1 A http://www.genome.jp/dbget-bin/www_bget?ko:K10684 Q28DS0 490 2.4e-47 SUMO-activating enzyme subunit 1 OS=Xenopus tropicalis GN=sae1 PE=2 SV=1 PF07243//PF00899 Phlebovirus glycoprotein G1//ThiF family -- -- GO:0008641 small protein activating enzyme activity GO:0019012//GO:0016021 virion//integral component of membrane KOG2014 SMT3/SUMO-activating complex, AOS1/RAD31 component Cluster-8309.49175 BF_2 18.15 0.68 1398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49177 BF_2 10.00 4.04 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49179 BF_2 82.00 7.41 750 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49180 BF_2 29.55 1.09 1419 270016115 EFA12563.1 267 1.0e-20 hypothetical protein TcasGA2_TC004192 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845//PF09009 CUE domain//Exotoxin A catalytic -- -- GO:0047286//GO:0005515 NAD+-diphthamide ADP-ribosyltransferase activity//protein binding -- -- -- -- Cluster-8309.49182 BF_2 11.28 1.57 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49183 BF_2 43.05 1.34 1634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02388 FemAB family GO:0009252 peptidoglycan biosynthetic process GO:0016755 transferase activity, transferring amino-acyl groups -- -- -- -- Cluster-8309.49184 BF_2 10.40 0.72 890 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49186 BF_2 32.86 0.59 2614 642917000 XP_008199589.1 426 6.8e-39 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11976 RNF216 TRIAD3; E3 ubiquitin-protein ligase RNF216 http://www.genome.jp/dbget-bin/www_bget?ko:K11976 P58283 153 1.3e-08 E3 ubiquitin-protein ligase RNF216 OS=Mus musculus GN=Rnf216 PE=1 SV=3 PF08050 Tetracycline resistance leader peptide GO:0046677 response to antibiotic -- -- -- -- -- -- Cluster-8309.49187 BF_2 29.95 1.77 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49188 BF_2 184.26 5.19 1773 642923014 XP_008200496.1 897 1.1e-93 PREDICTED: transcription factor GATA-5-like isoform X3 [Tribolium castaneum]>gi|270008081|gb|EFA04529.1| serpent [Tribolium castaneum] 642923013 XM_008202274.1 127 2.00609e-57 PREDICTED: Tribolium castaneum transcription factor GATA-4-like (LOC661909), transcript variant X3, mRNA K17896 GATA5 GATA-binding protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K17896 P52172 304 2.7e-26 Box A-binding factor OS=Drosophila melanogaster GN=srp PE=1 SV=2 PF01873//PF08752//PF00320 Domain found in IF2B/IF5//Coatomer gamma subunit appendage platform subdomain//GATA zinc finger GO:0016192//GO:0006446//GO:0006886//GO:0006355//GO:0006413 vesicle-mediated transport//regulation of translational initiation//intracellular protein transport//regulation of transcription, DNA-templated//translational initiation GO:0005198//GO:0003743//GO:0003700//GO:0008270//GO:0043565 structural molecule activity//translation initiation factor activity//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005840//GO:0030126 transcription factor complex//ribosome//COPI vesicle coat KOG1601 GATA-4/5/6 transcription factors Cluster-8309.49189 BF_2 6.00 2.62 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49191 BF_2 470.23 11.48 2001 642936656 XP_008198526.1 629 1.5e-62 PREDICTED: LOW QUALITY PROTEIN: probable nuclear transport factor 2 [Tribolium castaneum] 642936655 XM_008200304.1 162 7.93397e-77 PREDICTED: Tribolium castaneum nuclear transport factor-2 (LOC662356), mRNA -- -- -- -- Q21735 305 2.3e-26 Probable nuclear transport factor 2 OS=Caenorhabditis elegans GN=ran-4 PE=3 SV=1 PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular KOG2104 Nuclear transport factor 2 Cluster-8309.49192 BF_2 800.94 8.73 4127 91089273 XP_966340.1 958 2.2e-100 PREDICTED: autophagy-related protein 101 [Tribolium castaneum]>gi|270011443|gb|EFA07891.1| hypothetical protein TcasGA2_TC005466 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IH75 708 8.8e-73 Autophagy-related protein 101 OS=Xenopus tropicalis GN=atg101 PE=2 SV=1 PF00069//PF06293//PF07714//PF02907 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Hepatitis C virus NS3 protease GO:0006468//GO:0006508//GO:0019087 protein phosphorylation//proteolysis//transformation of host cell by virus GO:0005524//GO:0016773//GO:0004672//GO:0008236 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//serine-type peptidase activity GO:0016020 membrane KOG0598 Ribosomal protein S6 kinase and related proteins Cluster-8309.49193 BF_2 4.42 0.33 840 91084907 XP_969916.1 534 6.5e-52 PREDICTED: cytosolic 10-formyltetrahydrofolate dehydrogenase [Tribolium castaneum]>gi|270008989|gb|EFA05437.1| hypothetical protein TcasGA2_TC015614 [Tribolium castaneum] 642926047 XM_964823.2 49 2.13173e-14 PREDICTED: Tribolium castaneum cytosolic 10-formyltetrahydrofolate dehydrogenase (LOC658435), mRNA K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q3SY69 472 4.2e-46 Mitochondrial 10-formyltetrahydrofolate dehydrogenase OS=Homo sapiens GN=ALDH1L2 PE=1 SV=2 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491//GO:0016741 oxidoreductase activity//transferase activity, transferring one-carbon groups -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.49194 BF_2 435.97 3.75 5150 642914114 XP_008201549.1 3028 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X2 [Tribolium castaneum] 642914119 XM_008203330.1 557 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q68DX3 206 1.8e-14 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49197 BF_2 23.71 0.34 3190 270003145 EEZ99592.1 4002 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.3e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1094 Discoidin domain receptor DDR1 Cluster-8309.49199 BF_2 384.99 6.09 2931 642917574 XP_008191263.1 1239 4.1e-133 PREDICTED: zinc transporter ZIP11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14717 SLC39A11, ZIP11 solute carrier family 39 (zinc transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14717 Q8BWY7 763 2.6e-79 Zinc transporter ZIP11 OS=Mus musculus GN=Slc39a11 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2474 Zinc transporter and related ZIP domain-containing proteins Cluster-8309.49200 BF_2 337.89 5.43 2891 642917577 XP_008191264.1 1202 7.8e-129 PREDICTED: zinc transporter ZIP11 isoform X3 [Tribolium castaneum] -- -- -- -- -- K14717 SLC39A11, ZIP11 solute carrier family 39 (zinc transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14717 Q2YDD4 753 3.7e-78 Zinc transporter ZIP11 OS=Bos taurus GN=SLC39A11 PE=2 SV=1 PF02535 ZIP Zinc transporter GO:0030001//GO:0055085 metal ion transport//transmembrane transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2474 Zinc transporter and related ZIP domain-containing proteins Cluster-8309.49205 BF_2 152.46 5.98 1353 478258160 ENN78298.1 1380 8.4e-150 hypothetical protein YQE_05448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZV5 975 3.2e-104 Cysteine and histidine-rich protein 1 homolog OS=Drosophila melanogaster GN=CG32486 PE=2 SV=2 PF03145//PF00097//PF02176//PF13639 Seven in absentia protein family//Zinc finger, C3HC4 type (RING finger)//TRAF-type zinc finger//Ring finger domain GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0005515//GO:0046872//GO:0008270 protein binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.49207 BF_2 172.37 4.23 1991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49209 BF_2 9.00 0.69 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49210 BF_2 866.00 14.37 2808 189234759 XP_001814707.1 1633 8.0e-179 PREDICTED: SET and MYND domain-containing protein 5 [Tribolium castaneum]>gi|270001538|gb|EEZ97985.1| hypothetical protein TcasGA2_TC000380 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GPQ4 1083 2.0e-116 SET and MYND domain-containing protein 5 OS=Xenopus laevis GN=smyd5 PE=2 SV=1 PF07966//PF00856//PF04636//PF05279 A1 Propeptide//SET domain//PA26 p53-induced protein (sestrin)//Aspartyl beta-hydroxylase N-terminal region GO:1901031//GO:0006508 regulation of response to reactive oxygen species//proteolysis GO:0005515//GO:0004190 protein binding//aspartic-type endopeptidase activity GO:0016020//GO:0005634 membrane//nucleus KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.49214 BF_2 59.92 0.48 5462 642915644 XP_972006.3 3143 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.3e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.49218 BF_2 227.44 1.60 6227 612026501 XP_007492212.1 603 4.8e-59 PREDICTED: zinc finger protein 91-like [Monodelphis domestica] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9NYT6 585 2.4e-58 Zinc finger protein 226 OS=Homo sapiens GN=ZNF226 PE=2 SV=2 PF02053//PF00130//PF13465//PF00096//PF13912 Gene 66 (IR5) protein//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger GO:0035556 intracellular signal transduction GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.49219 BF_2 136.76 1.79 3477 91090880 XP_973129.1 851 4.7e-88 PREDICTED: serine/arginine repetitive matrix protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13172 SRRM2, SRM300 serine/arginine repetitive matrix protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13172 Q9UQ35 447 1.4e-42 Serine/arginine repetitive matrix protein 2 OS=Homo sapiens GN=SRRM2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1869 Splicing coactivator SRm160/300, subunit SRm300 Cluster-8309.49220 BF_2 1046.25 42.79 1310 91087023 XP_974255.1 1422 1.1e-154 PREDICTED: ethanolaminephosphotransferase 1-like [Tribolium castaneum] -- -- -- -- -- K00993 EPT1 ethanolaminephosphotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00993 Q9C0D9 802 3.5e-84 Ethanolaminephosphotransferase 1 OS=Homo sapiens GN=EPT1 PE=1 SV=3 PF01066//PF13292 CDP-alcohol phosphatidyltransferase//1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694//GO:0008654 terpenoid biosynthetic process//steroid biosynthetic process//phospholipid biosynthetic process GO:0008661//GO:0016780 1-deoxy-D-xylulose-5-phosphate synthase activity//phosphotransferase activity, for other substituted phosphate groups GO:0016020 membrane KOG2877 sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferases Cluster-8309.49221 BF_2 9.27 0.37 1322 270001008 EEZ97455.1 390 5.1e-35 hypothetical protein TcasGA2_TC011286 [Tribolium castaneum] -- -- -- -- -- K05527 bolA BolA protein http://www.genome.jp/dbget-bin/www_bget?ko:K05527 Q86KD0 282 7.0e-24 BolA-like protein DDB_G0274169 OS=Dictyostelium discoideum GN=DDB_G0274169 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG2313 Stress-induced protein UVI31+ Cluster-8309.49222 BF_2 69.22 1.23 2640 820805518 AKG92750.1 2539 6.6e-284 tango [Leptinotarsa decemlineata] 820805517 KP147913.1 351 0 Leptinotarsa decemlineata tango mRNA, complete cds K09097 ARNT aryl hydrocarbon receptor nuclear translocator http://www.genome.jp/dbget-bin/www_bget?ko:K09097 O15945 1775 1.1e-196 Aryl hydrocarbon receptor nuclear translocator homolog OS=Drosophila melanogaster GN=tgo PE=1 SV=3 PF00989//PF08447//PF00010 PAS fold//PAS fold//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49223 BF_2 95.39 1.67 2673 642914766 XP_008190343.1 639 1.4e-63 PREDICTED: trypsin II-P29-like [Tribolium castaneum]>gi|270002733|gb|EEZ99180.1| serine protease H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05319 329 5.1e-29 Serine proteinase stubble OS=Drosophila melanogaster GN=Sb PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.49224 BF_2 68.92 5.59 803 642932946 XP_008197199.1 581 2.2e-57 PREDICTED: sodium-independent sulfate anion transporter-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q58DD2 349 7.3e-32 Sodium-independent sulfate anion transporter OS=Bos taurus GN=SLC26A11 PE=2 SV=1 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49225 BF_2 4.08 0.46 659 805806150 XP_012145960.1 303 3.1e-25 PREDICTED: sodium-independent sulfate anion transporter-like isoform X1 [Megachile rotundata] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 215 2.1e-16 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF01566//PF00916 Natural resistance-associated macrophage protein//Sulfate permease family GO:0008272//GO:0006810 sulfate transport//transport GO:0015116//GO:0005215 sulfate transmembrane transporter activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.49226 BF_2 96.71 3.73 1373 270012481 EFA08929.1 901 3.0e-94 hypothetical protein TcasGA2_TC006636 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 576 5.9e-58 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.49228 BF_2 575.31 18.02 1623 642928571 XP_008199962.1 975 9.2e-103 PREDICTED: S-methyl-5'-thioadenosine phosphorylase [Tribolium castaneum] -- -- -- -- -- K00772 E2.4.2.28, mtaP 5'-methylthioadenosine phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00772 Q16MW6 940 4.3e-100 S-methyl-5'-thioadenosine phosphorylase OS=Aedes aegypti GN=AAEL012172 PE=3 SV=1 PF01048//PF12422 Phosphorylase superfamily//Condensin II non structural maintenance of chromosomes subunit GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity GO:0005634 nucleus KOG3985 Methylthioadenosine phosphorylase MTAP Cluster-8309.49229 BF_2 130.40 1.35 4321 642924318 XP_008194246.1 944 9.7e-99 PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|642924320|ref|XP_008194247.1| PREDICTED: anoctamin-10 isoform X1 [Tribolium castaneum]>gi|270008243|gb|EFA04691.1| abnormal X segregation [Tribolium castaneum] -- -- -- -- -- K19327 ANO10, TMEM16K anoctamin-10 http://www.genome.jp/dbget-bin/www_bget?ko:K19327 Q9NW15 374 5.0e-34 Anoctamin-10 OS=Homo sapiens GN=ANO10 PE=1 SV=2 -- -- GO:0006820//GO:0006821 anion transport//chloride transport GO:0005254 chloride channel activity GO:0034707 chloride channel complex -- -- Cluster-8309.49231 BF_2 14.24 0.71 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49233 BF_2 230.72 1.54 6573 91077990 XP_968879.1 2384 1.5e-265 PREDICTED: U4/U6 small nuclear ribonucleoprotein Prp3 [Tribolium castaneum]>gi|270001423|gb|EEZ97870.1| hypothetical protein TcasGA2_TC000245 [Tribolium castaneum] 642914786 XM_008192130.1 262 6.78036e-132 PREDICTED: Tribolium castaneum LIM domain-binding protein 2 (LOC657473), transcript variant X7, mRNA K12843 PRPF3, PRP3 U4/U6 small nuclear ribonucleoprotein PRP3 http://www.genome.jp/dbget-bin/www_bget?ko:K12843 Q922U1 1295 1.2e-140 U4/U6 small nuclear ribonucleoprotein Prp3 OS=Mus musculus GN=Prpf3 PE=2 SV=1 PF01480 PWI domain GO:0006397 mRNA processing -- -- -- -- KOG2769 Putative u4/u6 small nuclear ribonucleoprotein Cluster-8309.49234 BF_2 76.00 1.34 2665 591326172 XP_007089078.1 181 1.8e-10 PREDICTED: zinc finger protein 658-like isoform X1 [Panthera tigris altaica]>gi|591326174|ref|XP_007089079.1| PREDICTED: zinc finger protein 658-like isoform X2 [Panthera tigris altaica] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q4V348 178 1.6e-11 Zinc finger protein 658B OS=Homo sapiens GN=ZNF658B PE=2 SV=1 PF13912//PF00651//PF13465//PF02178//PF00096 C2H2-type zinc finger//BTB/POZ domain//Zinc-finger double domain//AT hook motif//Zinc finger, C2H2 type -- -- GO:0003677//GO:0005515//GO:0046872 DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.49235 BF_2 667.53 5.80 5105 642924872 XP_008194077.1 631 2.3e-62 PREDICTED: tubulin glycylase 3A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM92 435 4.9e-41 Tubulin glycylase 3B OS=Drosophila melanogaster GN=TTLL3B PE=1 SV=2 PF06156//PF04111//PF03194//PF03255//PF02601//PF03133 Protein of unknown function (DUF972)//Autophagy protein Apg6//LUC7 N_terminus//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//Exonuclease VII, large subunit//Tubulin-tyrosine ligase family GO:0006376//GO:0006464//GO:0006633//GO:0006914//GO:0006090//GO:0006260//GO:0006308 mRNA splice site selection//cellular protein modification process//fatty acid biosynthetic process//autophagy//pyruvate metabolic process//DNA replication//DNA catabolic process GO:0008855//GO:0003989//GO:0003729 exodeoxyribonuclease VII activity//acetyl-CoA carboxylase activity//mRNA binding GO:0005685//GO:0009318//GO:0009317 U1 snRNP//exodeoxyribonuclease VII complex//acetyl-CoA carboxylase complex KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.49236 BF_2 189.97 2.70 3232 642924872 XP_008194077.1 631 1.4e-62 PREDICTED: tubulin glycylase 3A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM92 435 3.1e-41 Tubulin glycylase 3B OS=Drosophila melanogaster GN=TTLL3B PE=1 SV=2 PF03133 Tubulin-tyrosine ligase family GO:0006464 cellular protein modification process -- -- -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.49239 BF_2 142.02 0.40 15260 642914247 XP_008201606.1 19171 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10506 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF08717//PF00008//PF07645 Cadherin domain//nsp8 replicase//EGF-like domain//Calcium-binding EGF domain GO:0007156//GO:0006508 homophilic cell adhesion via plasma membrane adhesion molecules//proteolysis GO:0008242//GO:0016740//GO:0005515//GO:0005509//GO:0004197 omega peptidase activity//transferase activity//protein binding//calcium ion binding//cysteine-type endopeptidase activity GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.49240 BF_2 544.29 1.62 14346 189241098 XP_971301.2 13697 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13D [Tribolium castaneum] -- -- -- -- -- K19527 VPS13D vacuolar protein sorting-associated protein 13D http://www.genome.jp/dbget-bin/www_bget?ko:K19527 Q5THJ4 2751 3.9e-309 Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.49241 BF_2 90.02 0.99 4082 478253469 ENN73796.1 2068 4.2e-229 hypothetical protein YQE_09574, partial [Dendroctonus ponderosae] -- -- -- -- -- K08863 PLK4 polo-like kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08863 A2VDZ4 1218 6.3e-132 Serine/threonine-protein kinase PLK4 OS=Bos taurus GN=PLK4 PE=2 SV=1 PF07714//PF00069//PF00050//PF06293//PF07648 Protein tyrosine kinase//Protein kinase domain//Kazal-type serine protease inhibitor domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Kazal-type serine protease inhibitor domain GO:0006468 protein phosphorylation GO:0004672//GO:0005515//GO:0005524//GO:0016773 protein kinase activity//protein binding//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.49244 BF_2 62.40 0.75 3772 546673143 ERL84808.1 760 1.8e-77 hypothetical protein D910_02232 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3T1L0 197 1.4e-13 Aldehyde dehydrogenase family 16 member A1 OS=Rattus norvegicus GN=Aldh16a1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.49245 BF_2 182.83 1.46 5539 546675155 ERL86391.1 1444 1.3e-156 hypothetical protein D910_03799 [Dendroctonus ponderosae] -- -- -- -- -- K14859 SSF1_2 ribosome biogenesis protein SSF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K14859 Q9VDE5 984 1.2e-104 Protein Peter pan OS=Drosophila melanogaster GN=ppan PE=1 SV=1 PF02086//PF14721//PF13414//PF00515//PF03602//PF13371//PF01555//PF02384//PF13181//PF08241//PF14863//PF05944 D12 class N6 adenine-specific DNA methyltransferase//Apoptosis-inducing factor, mitochondrion-associated, C-term//TPR repeat//Tetratricopeptide repeat//Conserved hypothetical protein 95//Tetratricopeptide repeat//DNA methylase//N-6 DNA Methylase//Tetratricopeptide repeat//Methyltransferase domain//Alkyl sulfatase dimerisation//Phage small terminase subunit GO:0031167//GO:0032775//GO:0008152//GO:0006306//GO:0019069 rRNA methylation//DNA methylation on adenine//metabolic process//DNA methylation//viral capsid assembly GO:0005515//GO:0046983//GO:0003677//GO:0004519//GO:0009007//GO:0008170//GO:0008168 protein binding//protein dimerization activity//DNA binding//endonuclease activity//site-specific DNA-methyltransferase (adenine-specific) activity//N-methyltransferase activity//methyltransferase activity -- -- KOG2963 RNA-binding protein required for 60S ribosomal subunit biogenesis Cluster-8309.49246 BF_2 535.65 2.99 7771 642914403 XP_008201481.1 2818 0.0e+00 PREDICTED: TELO2-interacting protein 1 homolog [Tribolium castaneum] 780665329 XM_011695591.1 121 1.93114e-53 PREDICTED: Wasmannia auropunctata uncharacterized LOC105453540 (LOC105453540), mRNA -- -- -- -- Q9BY31 411 4.6e-38 Zinc finger protein 717 OS=Homo sapiens GN=ZNF717 PE=2 SV=2 PF14634//PF00628//PF16866//PF00569//PF00096//PF13912//PF00412//PF05191//PF01428//PF08064//PF13465//PF07975 zinc-RING finger domain//PHD-finger//PHD-finger//Zinc finger, ZZ type//Zinc finger, C2H2 type//C2H2-type zinc finger//LIM domain//Adenylate kinase, active site lid//AN1-like Zinc finger//UME (NUC010) domain//Zinc-finger double domain//TFIIH C1-like domain GO:0016310//GO:0006281//GO:0009069//GO:0006144//GO:0046034 phosphorylation//DNA repair//serine family amino acid metabolic process//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0046872//GO:0004674//GO:0004017//GO:0005515 zinc ion binding//metal ion binding//protein serine/threonine kinase activity//adenylate kinase activity//protein binding -- -- -- -- Cluster-8309.49248 BF_2 25.82 0.38 3133 91084345 XP_972963.1 1879 2.7e-207 PREDICTED: SH2B adapter protein 2 isoform X1 [Tribolium castaneum]>gi|270008825|gb|EFA05273.1| hypothetical protein TcasGA2_TC015430 [Tribolium castaneum] -- -- -- -- -- K12459 SH2B1_3 SH2B adaptor protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K12459 Q9UQQ2 476 5.3e-46 SH2B adapter protein 3 OS=Homo sapiens GN=SH2B3 PE=1 SV=2 PF00583//PF13508//PF08916//PF01395 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Phenylalanine zipper//PBP/GOBP family GO:0007165//GO:0042967//GO:0035556 signal transduction//acyl-carrier-protein biosynthetic process//intracellular signal transduction GO:0005549//GO:0005543//GO:0008080//GO:0004871 odorant binding//phospholipid binding//N-acetyltransferase activity//signal transducer activity GO:0005622 intracellular -- -- Cluster-8309.49249 BF_2 84.71 0.42 8816 91081101 XP_975504.1 3888 0.0e+00 PREDICTED: DNA topoisomerase 3-beta-1 [Tribolium castaneum]>gi|270005298|gb|EFA01746.1| hypothetical protein TcasGA2_TC007344 [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 O95985 2923 0.0e+00 DNA topoisomerase 3-beta-1 OS=Homo sapiens GN=TOP3B PE=1 SV=1 PF04421//PF13855//PF00560//PF01131 Mss4 protein//Leucine rich repeat//Leucine Rich Repeat//DNA topoisomerase GO:0006265//GO:0007264//GO:0043087 DNA topological change//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005515//GO:0003916//GO:0003677//GO:0003917//GO:0005085 protein binding//DNA topoisomerase activity//DNA binding//DNA topoisomerase type I activity//guanyl-nucleotide exchange factor activity GO:0005694 chromosome KOG1956 DNA topoisomerase III alpha Cluster-8309.4925 BF_2 27.00 1.22 1210 662192401 XP_008469056.1 154 1.1e-07 PREDICTED: uncharacterized protein LOC103506445 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.49250 BF_2 761.18 3.98 8296 91081101 XP_975504.1 3888 0.0e+00 PREDICTED: DNA topoisomerase 3-beta-1 [Tribolium castaneum]>gi|270005298|gb|EFA01746.1| hypothetical protein TcasGA2_TC007344 [Tribolium castaneum] -- -- -- -- -- K03165 TOP3 DNA topoisomerase III http://www.genome.jp/dbget-bin/www_bget?ko:K03165 O95985 2923 0.0e+00 DNA topoisomerase 3-beta-1 OS=Homo sapiens GN=TOP3B PE=1 SV=1 PF00560//PF01131//PF04421//PF13855 Leucine Rich Repeat//DNA topoisomerase//Mss4 protein//Leucine rich repeat GO:0043087//GO:0006265//GO:0007264 regulation of GTPase activity//DNA topological change//small GTPase mediated signal transduction GO:0003917//GO:0003677//GO:0005085//GO:0005515//GO:0003916 DNA topoisomerase type I activity//DNA binding//guanyl-nucleotide exchange factor activity//protein binding//DNA topoisomerase activity GO:0005694 chromosome KOG1956 DNA topoisomerase III alpha Cluster-8309.49252 BF_2 27.00 3.09 653 642911734 XP_008200718.1 540 1.0e-52 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC660336 [Tribolium castaneum] 768412001 XM_011568499.1 42 1.27458e-10 PREDICTED: Plutella xylostella serine/arginine repetitive matrix protein 1 (LOC105396496), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49253 BF_2 99.84 2.37 2052 642911278 XP_008199353.1 1882 7.8e-208 PREDICTED: glutamate-gated chloride channel isoform X3 [Tribolium castaneum] 768428214 XM_011556933.1 327 1.54035e-168 PREDICTED: Plutella xylostella glutamate-gated chloride channel-like (LOC105386383), transcript variant X8, mRNA K05273 GRGLCN glutamate receptor, anionic, other http://www.genome.jp/dbget-bin/www_bget?ko:K05273 Q94900 1639 4.9e-181 Glutamate-gated chloride channel OS=Drosophila melanogaster GN=GluClalpha PE=1 SV=2 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3644 Ligand-gated ion channel Cluster-8309.49257 BF_2 131.00 9.74 850 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49259 BF_2 172.09 1.84 4190 546671782 ERL83947.1 882 1.4e-91 hypothetical protein D910_01240 [Dendroctonus ponderosae]>gi|546671784|gb|ERL83948.1| hypothetical protein D910_01241 [Dendroctonus ponderosae] 642930107 XM_008198033.1 119 1.34216e-52 PREDICTED: Tribolium castaneum probable 2-oxoglutarate dehydrogenase E1 component DHKTD1 homolog, mitochondrial (LOC656360), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF07839 Plant calmodulin-binding domain -- -- GO:0005516 calmodulin binding -- -- -- -- Cluster-8309.49260 BF_2 100.42 0.62 7078 166998249 NP_001107795.1 2592 1.3e-289 CYCLE [Tribolium castaneum]>gi|140270864|gb|ABO86538.1| CYCLE [Tribolium castaneum] 121945612 AB289690.1 179 1.00698e-85 Dianemobius nigrofasciatus mRNA for circadian transcription modulator CYCLE, partial cds K02296 ARNTL, BMAL1, CYC aryl hydrocarbon receptor nuclear translocator-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02296 A0MLS5 1442 1.2e-157 Aryl hydrocarbon receptor nuclear translocator-like protein 1 OS=Equus caballus GN=ARNTL PE=2 SV=1 PF08447//PF08446//PF00010//PF00989//PF02159 PAS fold//PAS fold//Helix-loop-helix DNA-binding domain//PAS fold//Oestrogen receptor GO:0043401//GO:0006355//GO:0007165 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0004871//GO:0030284//GO:0005496//GO:0003700//GO:0003677//GO:0005515//GO:0046983 signal transducer activity//estrogen receptor activity//steroid binding//transcription factor activity, sequence-specific DNA binding//DNA binding//protein binding//protein dimerization activity GO:0005737//GO:0005634//GO:0005667 cytoplasm//nucleus//transcription factor complex KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49264 BF_2 1.00 1.09 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49266 BF_2 201.36 1.29 6795 166998249 NP_001107795.1 2587 4.6e-289 CYCLE [Tribolium castaneum]>gi|140270864|gb|ABO86538.1| CYCLE [Tribolium castaneum] 121945612 AB289690.1 179 9.66506e-86 Dianemobius nigrofasciatus mRNA for circadian transcription modulator CYCLE, partial cds K02296 ARNTL, BMAL1, CYC aryl hydrocarbon receptor nuclear translocator-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02296 A0MLS5 1442 1.1e-157 Aryl hydrocarbon receptor nuclear translocator-like protein 1 OS=Equus caballus GN=ARNTL PE=2 SV=1 PF02159//PF00989//PF08446//PF08447//PF00010 Oestrogen receptor//PAS fold//PAS fold//PAS fold//Helix-loop-helix DNA-binding domain GO:0043401//GO:0006355//GO:0007165 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0004871//GO:0030284//GO:0005496//GO:0005515//GO:0046983//GO:0003677 transcription factor activity, sequence-specific DNA binding//signal transducer activity//estrogen receptor activity//steroid binding//protein binding//protein dimerization activity//DNA binding GO:0005737//GO:0005667//GO:0005634 cytoplasm//transcription factor complex//nucleus KOG3561 Aryl-hydrocarbon receptor nuclear translocator Cluster-8309.49267 BF_2 63.00 1.25 2389 91079360 XP_970234.1 2639 1.5e-295 PREDICTED: armadillo repeat-containing protein 8 [Tribolium castaneum]>gi|270004363|gb|EFA00811.1| hypothetical protein TcasGA2_TC003698 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBR3 1449 6.1e-159 Armadillo repeat-containing protein 8 OS=Mus musculus GN=Armc8 PE=2 SV=2 PF11698//PF00514//PF12031//PF01602//PF02985//PF04869 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Domain of unknown function (DUF3518)//Adaptin N terminal region//HEAT repeat//Uso1 / p115 like vesicle tethering protein, head region GO:0006338//GO:0006886//GO:0015991//GO:0048280//GO:0016192 chromatin remodeling//intracellular protein transport//ATP hydrolysis coupled proton transport//vesicle fusion with Golgi apparatus//vesicle-mediated transport GO:0016820//GO:0005515 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein binding GO:0005737//GO:0030117//GO:0000139//GO:0090544//GO:0000221 cytoplasm//membrane coat//Golgi membrane//BAF-type complex//vacuolar proton-transporting V-type ATPase, V1 domain -- -- Cluster-8309.4927 BF_2 6.01 1.08 521 478259603 ENN79456.1 143 8.8e-07 hypothetical protein YQE_04100, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887//PF10152//PF01607//PF01299 Procyclic acidic repetitive protein (PARP)//Predicted coiled-coil domain-containing protein (DUF2360)//Chitin binding Peritrophin-A domain//Lysosome-associated membrane glycoprotein (Lamp) GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576//GO:0016020//GO:0071203 extracellular region//membrane//WASH complex -- -- Cluster-8309.49272 BF_2 218.75 1.74 5542 642915644 XP_972006.3 3111 0.0e+00 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.5e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.49273 BF_2 21.00 6.34 425 765336429 XP_011493101.1 225 2.2e-16 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- -- -- -- -- Q804S5 174 7.5e-12 E3 ubiquitin-protein ligase mib1 OS=Danio rerio GN=mib1 PE=1 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.49282 BF_2 458.52 9.24 2364 478252633 ENN73038.1 1374 7.3e-149 hypothetical protein YQE_10373, partial [Dendroctonus ponderosae] -- -- -- -- -- K13963 SERPINB serpin B http://www.genome.jp/dbget-bin/www_bget?ko:K13963 P48594 528 3.8e-52 Serpin B4 OS=Homo sapiens GN=SERPINB4 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49287 BF_2 104.47 1.61 2997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49288 BF_2 52.64 1.36 1907 189235302 XP_001816128.1 402 3.0e-36 PREDICTED: H/ACA ribonucleoprotein complex subunit 1 [Tribolium castaneum]>gi|270003676|gb|EFA00124.1| hypothetical protein TcasGA2_TC002940 [Tribolium castaneum] 766934267 XM_011501142.1 68 1.35683e-24 PREDICTED: Ceratosolen solmsi marchali probable H/ACA ribonucleoprotein complex subunit 1 (LOC105363452), mRNA K11128 GAR1, NOLA1 H/ACA ribonucleoprotein complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11128 Q7KVQ0 330 2.8e-29 Probable H/ACA ribonucleoprotein complex subunit 1 OS=Drosophila melanogaster GN=CG4038 PE=1 SV=1 PF04410 Gar1/Naf1 RNA binding region GO:0042254//GO:0001522//GO:0031120 ribosome biogenesis//pseudouridine synthesis//snRNA pseudouridine synthesis GO:0030515//GO:0009982 snoRNA binding//pseudouridine synthase activity GO:0031429 box H/ACA snoRNP complex KOG3262 H/ACA small nucleolar RNP component GAR1 Cluster-8309.49289 BF_2 127.32 4.82 1392 339238571 XP_003380840.1 186 2.4e-11 zinc knuckle protein [Trichinella spiralis]>gi|316976211|gb|EFV59539.1| zinc knuckle protein [Trichinella spiralis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49291 BF_2 70.52 6.01 778 642915298 XP_008190560.1 882 2.7e-92 PREDICTED: JNK-interacting protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29EP6 560 2.4e-56 JNK-interacting protein 3 OS=Drosophila pseudoobscura pseudoobscura GN=syd PE=3 SV=2 PF01763//PF04977//PF06156//PF04111//PF01496//PF04508//PF10186//PF06005//PF10473//PF05837//PF17082//PF00458 Herpesvirus UL6 like//Septum formation initiator//Protein of unknown function (DUF972)//Autophagy protein Apg6//V-type ATPase 116kDa subunit family//Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14//Protein of unknown function (DUF904)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centromere protein H (CENP-H)//Spindle Pole Component 29//WHEP-TRS domain GO:0006418//GO:0000917//GO:0043093//GO:0016032//GO:0015991//GO:0030474//GO:0006260//GO:0007049//GO:0006323//GO:0010508//GO:0015992//GO:0051382//GO:0006914 tRNA aminoacylation for protein translation//barrier septum assembly//FtsZ-dependent cytokinesis//viral process//ATP hydrolysis coupled proton transport//spindle pole body duplication//DNA replication//cell cycle//DNA packaging//positive regulation of autophagy//proton transport//kinetochore assembly//autophagy GO:0042803//GO:0015078//GO:0005200//GO:0004812//GO:0005524//GO:0008134//GO:0045502 protein homodimerization activity//hydrogen ion transmembrane transporter activity//structural constituent of cytoskeleton//aminoacyl-tRNA ligase activity//ATP binding//transcription factor binding//dynein binding GO:0000776//GO:0033179//GO:0005856//GO:0030286//GO:0005667//GO:0005823//GO:0005737 kinetochore//proton-transporting V-type ATPase, V0 domain//cytoskeleton//dynein complex//transcription factor complex//central plaque of spindle pole body//cytoplasm KOG2077 JNK/SAPK-associated protein-1 Cluster-8309.49293 BF_2 13.00 0.84 932 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49296 BF_2 2.03 0.40 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49298 BF_2 61.79 0.36 7427 642927006 XP_008195101.1 3735 0.0e+00 PREDICTED: protein disabled isoform X4 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 681 2.1e-69 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF07415//PF00640//PF14719 Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID) GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.49299 BF_2 165.00 2.93 2639 642912479 XP_008200881.1 1779 8.9e-196 PREDICTED: synaptic vesicular amine transporter [Tribolium castaneum]>gi|642912481|ref|XP_008200882.1| PREDICTED: synaptic vesicular amine transporter [Tribolium castaneum] -- -- -- -- -- K08155 SLC18A1_2, VMAT MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K08155 Q8BRU6 1053 5.6e-113 Synaptic vesicular amine transporter OS=Mus musculus GN=Slc18a2 PE=1 SV=1 PF07690//PF00083//PF02892 Major Facilitator Superfamily//Sugar (and other) transporter//BED zinc finger GO:0055085 transmembrane transport GO:0003677//GO:0022857 DNA binding//transmembrane transporter activity GO:0016021 integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.49301 BF_2 59.38 0.90 3040 642921918 XP_008192944.1 1544 1.8e-168 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15326 593 1.4e-59 Zinc finger MYND domain-containing protein 11 OS=Homo sapiens GN=ZMYND11 PE=1 SV=2 PF00628//PF00130//PF00439 PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//Bromodomain GO:0035556 intracellular signal transduction GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.49303 BF_2 272.30 6.08 2162 642939069 XP_008200209.1 1427 4.8e-155 PREDICTED: HIV Tat-specific factor 1 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K13093 HTATSF1 HIV Tat-specific factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13093 Q5RB63 749 8.1e-78 HIV Tat-specific factor 1 homolog OS=Pongo abelii GN=HTATSF1 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG1548 Transcription elongation factor TAT-SF1 Cluster-8309.49307 BF_2 26.40 6.53 456 642910556 XP_008200264.1 766 4.4e-79 PREDICTED: ras-related protein Rab6 isoform X1 [Tribolium castaneum] 721611937 XM_010239811.1 71 6.59389e-27 PREDICTED: Brachypodium distachyon ras-related protein RABH1b (LOC100823113), mRNA K07893 RAB6A Ras-related protein Rab-6A http://www.genome.jp/dbget-bin/www_bget?ko:K07893 O18334 713 2.5e-74 Ras-related protein Rab6 OS=Drosophila melanogaster GN=Rab6 PE=1 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0094 GTPase Rab6/YPT6/Ryh1, small G protein superfamily Cluster-8309.49308 BF_2 591.88 6.87 3890 546680213 ERL90536.1 630 2.2e-62 hypothetical protein D910_07884 [Dendroctonus ponderosae] -- -- -- -- -- K12887 HNRNPM heterogeneous nuclear ribonucleoprotein M http://www.genome.jp/dbget-bin/www_bget?ko:K12887 Q9D0E1 281 2.7e-23 Heterogeneous nuclear ribonucleoprotein M OS=Mus musculus GN=Hnrnpm PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG4212 RNA-binding protein hnRNP-M Cluster-8309.49309 BF_2 5.15 0.86 538 642915807 XP_008200086.1 414 3.4e-38 PREDICTED: WD repeat-containing protein 47 [Tribolium castaneum] 766926462 XM_011496875.1 94 1.28667e-39 PREDICTED: Ceratosolen solmsi marchali WD repeat-containing protein 47 (LOC105360084), transcript variant X5, mRNA -- -- -- -- O94967 258 1.7e-21 WD repeat-containing protein 47 OS=Homo sapiens GN=WDR47 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0641 WD40 repeat protein Cluster-8309.49311 BF_2 574.83 15.87 1802 332373366 AEE61824.1 1600 3.4e-175 unknown [Dendroctonus ponderosae]>gi|478258142|gb|ENN78280.1| hypothetical protein YQE_05431, partial [Dendroctonus ponderosae] 391342831 XM_003745671.1 69 3.56089e-25 PREDICTED: Metaseiulus occidentalis GMP reductase 2-like (LOC100902322), mRNA K00364 E1.7.1.7, guaC GMP reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00364 Q9DCZ1 1399 2.9e-153 GMP reductase 1 OS=Mus musculus GN=Gmpr PE=2 SV=1 PF01081//PF00478//PF01070 KDPG and KHG aldolase//IMP dehydrogenase / GMP reductase domain//FMN-dependent dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016829//GO:0016491//GO:0003824 lyase activity//oxidoreductase activity//catalytic activity -- -- KOG2550 IMP dehydrogenase/GMP reductase Cluster-8309.49312 BF_2 4.29 0.78 516 91077988 XP_968808.1 167 1.4e-09 PREDICTED: protein SERAC1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49316 BF_2 55.00 2.94 1069 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49318 BF_2 372.87 8.47 2128 827546729 XP_012545763.1 331 5.7e-28 PREDICTED: uncharacterized protein LOC105841624 isoform X1 [Bombyx mori] -- -- -- -- -- -- -- -- -- Q9YMJ7 144 1.1e-07 Envelope fusion protein OS=Lymantria dispar multicapsid nuclear polyhedrosis virus GN=LdOrf-130 PE=3 SV=1 PF03728//PF06009//PF06008//PF01105//PF04108 Viral DNA-binding protein, zinc binding domain//Laminin Domain II//Laminin Domain I//emp24/gp25L/p24 family/GOLD//Autophagy protein Apg17 GO:0030334//GO:0007165//GO:0006914//GO:0006810//GO:0007155//GO:0030155//GO:0006260//GO:0045995 regulation of cell migration//signal transduction//autophagy//transport//cell adhesion//regulation of cell adhesion//DNA replication//regulation of embryonic development GO:0003677//GO:0008270//GO:0005102 DNA binding//zinc ion binding//receptor binding GO:0016021 integral component of membrane -- -- Cluster-8309.49319 BF_2 33.83 0.33 4563 642940154 XP_008194847.1 912 5.2e-95 PREDICTED: myoneurin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 336 1.3e-29 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF00651//PF04218//PF01527//PF00376//PF02714 BTB/POZ domain//CENP-B N-terminal DNA-binding domain//Transposase//MerR family regulatory protein//Calcium-dependent channel, 7TM region, putative phosphate GO:0006313//GO:0006355 transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0005515//GO:0004803//GO:0003677 protein binding//transposase activity//DNA binding GO:0016020 membrane -- -- Cluster-8309.49321 BF_2 568.74 9.14 2889 642933538 XP_008197461.1 3463 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 4 [Tribolium castaneum]>gi|270011334|gb|EFA07782.1| hypothetical protein TcasGA2_TC005339 [Tribolium castaneum] 817186761 XM_012432473.1 151 1.49947e-70 PREDICTED: Orussus abietinus tyrosine-protein phosphatase non-receptor type 4 (LOC105703795), transcript variant X5, mRNA K18037 PTPN4, MEG tyrosine-protein phosphatase non-receptor type 4 http://www.genome.jp/dbget-bin/www_bget?ko:K18037 Q9WU22 1835 1.3e-203 Tyrosine-protein phosphatase non-receptor type 4 OS=Mus musculus GN=Ptpn4 PE=1 SV=2 PF00782//PF13180//PF00595//PF00102 Dual specificity phosphatase, catalytic domain//PDZ domain//PDZ domain (Also known as DHR or GLGF)//Protein-tyrosine phosphatase GO:0035335//GO:0006470//GO:0006570 peptidyl-tyrosine dephosphorylation//protein dephosphorylation//tyrosine metabolic process GO:0004725//GO:0008138//GO:0005515 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein binding GO:0005856 cytoskeleton KOG0792 Protein tyrosine phosphatase PTPMEG, contains FERM domain Cluster-8309.49323 BF_2 193.00 4.76 1984 -- -- -- -- -- 642926596 XM_008196712.1 35 3.12342e-06 PREDICTED: Tribolium castaneum fasciclin-3 (LOC657272), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49324 BF_2 211.05 2.31 4104 189238110 XP_001814014.1 2184 1.5e-242 PREDICTED: PHD finger protein 12 [Tribolium castaneum]>gi|270008739|gb|EFA05187.1| hypothetical protein TcasGA2_TC015317 [Tribolium castaneum] -- -- -- -- -- K13703 ABHD11 abhydrolase domain-containing protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13703 Q6DRD9 608 3.5e-61 Alpha/beta hydrolase domain-containing protein 11 OS=Danio rerio GN=abhd11 PE=2 SV=1 PF00130//PF00628//PF00498//PF01738//PF03403//PF02450//PF07819//PF12740//PF01764//PF04083//PF07224//PF00975 Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//FHA domain//Dienelactone hydrolase family//Platelet-activating factor acetylhydrolase, isoform II//Lecithin:cholesterol acyltransferase//PGAP1-like protein//Chlorophyllase enzyme//Lipase (class 3)//Partial alpha/beta-hydrolase lipase region//Chlorophyllase//Thioesterase domain GO:0006886//GO:0042967//GO:0006505//GO:0015996//GO:0035556//GO:0046486//GO:0009058//GO:0015994//GO:0006629//GO:0016042 intracellular protein transport//acyl-carrier-protein biosynthetic process//GPI anchor metabolic process//chlorophyll catabolic process//intracellular signal transduction//glycerolipid metabolic process//biosynthetic process//chlorophyll metabolic process//lipid metabolic process//lipid catabolic process GO:0003847//GO:0016787//GO:0008374//GO:0047746//GO:0005515//GO:0016788 1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity//O-acyltransferase activity//chlorophyllase activity//protein binding//hydrolase activity, acting on ester bonds GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG2382 Predicted alpha/beta hydrolase Cluster-8309.49325 BF_2 90.07 0.96 4215 189238110 XP_001814014.1 2258 4.1e-251 PREDICTED: PHD finger protein 12 [Tribolium castaneum]>gi|270008739|gb|EFA05187.1| hypothetical protein TcasGA2_TC015317 [Tribolium castaneum] -- -- -- -- -- K13703 ABHD11 abhydrolase domain-containing protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13703 Q6DRD9 526 1.1e-51 Alpha/beta hydrolase domain-containing protein 11 OS=Danio rerio GN=abhd11 PE=2 SV=1 PF04083//PF01764//PF07819//PF00975//PF01674//PF07224//PF00130//PF00498//PF00628 Partial alpha/beta-hydrolase lipase region//Lipase (class 3)//PGAP1-like protein//Thioesterase domain//Lipase (class 2)//Chlorophyllase//Phorbol esters/diacylglycerol binding domain (C1 domain)//FHA domain//PHD-finger GO:0009058//GO:0035556//GO:0015996//GO:0006505//GO:0006886//GO:0006629//GO:0015994 biosynthetic process//intracellular signal transduction//chlorophyll catabolic process//GPI anchor metabolic process//intracellular protein transport//lipid metabolic process//chlorophyll metabolic process GO:0016787//GO:0016788//GO:0047746//GO:0005515 hydrolase activity//hydrolase activity, acting on ester bonds//chlorophyllase activity//protein binding -- -- KOG2382 Predicted alpha/beta hydrolase Cluster-8309.49329 BF_2 716.00 256.05 403 642925880 XP_969481.2 393 7.0e-36 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 249 1.4e-20 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF01073//PF00106//PF01370 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0006694//GO:0055114//GO:0008209//GO:0008207//GO:0008210//GO:0008152 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process//metabolic process GO:0016491//GO:0016616//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.49330 BF_2 99.00 2.62 1870 91081371 XP_971796.1 907 8.2e-95 PREDICTED: coiled-coil domain-containing protein 94 [Tribolium castaneum]>gi|270005184|gb|EFA01632.1| hypothetical protein TcasGA2_TC007202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BW85 635 1.2e-64 Coiled-coil domain-containing protein 94 OS=Homo sapiens GN=CCDC94 PE=1 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- KOG2989 Uncharacterized conserved protein Cluster-8309.49331 BF_2 144.81 9.26 941 642923845 XP_008193902.1 738 1.6e-75 PREDICTED: uncharacterized protein LOC662374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P82198 183 1.5e-12 Transforming growth factor-beta-induced protein ig-h3 OS=Mus musculus GN=Tgfbi PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49332 BF_2 371.14 1.15 13813 478254656 ENN74897.1 8505 0.0e+00 hypothetical protein YQE_08475, partial [Dendroctonus ponderosae] 611970121 XM_007480100.1 108 5.79685e-46 PREDICTED: Monodelphis domestica HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 (HERC1), mRNA K10594 HERC1 E3 ubiquitin-protein ligase HERC1 http://www.genome.jp/dbget-bin/www_bget?ko:K10594 Q15751 3927 0.0e+00 Probable E3 ubiquitin-protein ligase HERC1 OS=Homo sapiens GN=HERC1 PE=1 SV=2 PF01475//PF06817//PF00400//PF00622//PF00632 Ferric uptake regulator family//Reverse transcriptase thumb domain//WD domain, G-beta repeat//SPRY domain//HECT-domain (ubiquitin-transferase) GO:0016567//GO:0006278//GO:0006355 protein ubiquitination//RNA-dependent DNA replication//regulation of transcription, DNA-templated GO:0003964//GO:0004842//GO:0005515//GO:0003700 RNA-directed DNA polymerase activity//ubiquitin-protein transferase activity//protein binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG1426 FOG: RCC1 domain Cluster-8309.49333 BF_2 22.41 0.34 3019 91084515 XP_967225.1 751 1.6e-76 PREDICTED: double-stranded RNA-specific editase Adar [Tribolium castaneum]>gi|270012651|gb|EFA09099.1| hypothetical protein TcasGA2_TC015220 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03368 Dicer dimerisation domain GO:0051252 regulation of RNA metabolic process GO:0016891//GO:0003723 endoribonuclease activity, producing 5'-phosphomonoesters//RNA binding -- -- -- -- Cluster-8309.49336 BF_2 239.22 2.63 4089 270009970 EFA06418.1 1501 2.4e-163 hypothetical protein TcasGA2_TC009297 [Tribolium castaneum] 642927421 XM_962345.3 282 3.20564e-143 PREDICTED: Tribolium castaneum uncharacterized LOC655783 (LOC655783), mRNA -- -- -- -- -- -- -- -- PF06736 Protein of unknown function (DUF1211) GO:0006813 potassium ion transport GO:0005267 potassium channel activity -- -- -- -- Cluster-8309.49337 BF_2 34.52 0.43 3653 189238817 XP_967438.2 689 3.0e-69 PREDICTED: uncharacterized protein LOC655783 [Tribolium castaneum] 642927421 XM_962345.3 208 3.91616e-102 PREDICTED: Tribolium castaneum uncharacterized LOC655783 (LOC655783), mRNA -- -- -- -- -- -- -- -- PF04382//PF06736 SAB domain//Protein of unknown function (DUF1211) GO:0030866//GO:0006813 cortical actin cytoskeleton organization//potassium ion transport GO:0008092//GO:0005267 cytoskeletal protein binding//potassium channel activity GO:0005856 cytoskeleton -- -- Cluster-8309.49338 BF_2 34.78 0.33 4753 91082539 XP_973726.1 1447 5.0e-157 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T052 800 2.2e-83 Inter-alpha-trypsin inhibitor heavy chain H4 OS=Bos taurus GN=ITIH4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49345 BF_2 112.78 2.47 2194 642912278 XP_967486.2 753 6.9e-77 PREDICTED: prolow-density lipoprotein receptor-related protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 335 8.4e-30 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.49346 BF_2 92.10 0.75 5418 91084477 XP_971283.1 1848 1.8e-203 PREDICTED: uncharacterized protein LOC659924 [Tribolium castaneum]>gi|270008871|gb|EFA05319.1| hypothetical protein TcasGA2_TC015477 [Tribolium castaneum] -- -- -- -- -- K10581 UBE2O ubiquitin-conjugating enzyme E2 O http://www.genome.jp/dbget-bin/www_bget?ko:K10581 Q9C0C9 640 8.9e-65 E2/E3 hybrid ubiquitin-protein ligase UBE2O OS=Homo sapiens GN=UBE2O PE=1 SV=3 PF05743 UEV domain GO:0015031//GO:0006464 protein transport//cellular protein modification process -- -- -- -- KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.49348 BF_2 216.61 1.98 4853 91084477 XP_971283.1 2934 0.0e+00 PREDICTED: uncharacterized protein LOC659924 [Tribolium castaneum]>gi|270008871|gb|EFA05319.1| hypothetical protein TcasGA2_TC015477 [Tribolium castaneum] -- -- -- -- -- K10581 UBE2O ubiquitin-conjugating enzyme E2 O http://www.genome.jp/dbget-bin/www_bget?ko:K10581 Q9C0C9 640 8.0e-65 E2/E3 hybrid ubiquitin-protein ligase UBE2O OS=Homo sapiens GN=UBE2O PE=1 SV=3 -- -- -- -- -- -- -- -- KOG0895 Ubiquitin-conjugating enzyme Cluster-8309.49349 BF_2 642.83 7.22 4013 91079492 XP_968664.1 1430 4.0e-155 PREDICTED: RING finger and transmembrane domain-containing protein 2 [Tribolium castaneum]>gi|270003440|gb|EEZ99887.1| hypothetical protein TcasGA2_TC002671 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UF64 482 1.4e-46 RING finger and transmembrane domain-containing protein 2 OS=Mus musculus GN=Rnft2 PE=2 SV=2 PF15185//PF11789//PF13639//PF12678//PF14634//PF12861//PF00097 Bcl-2-modifying factor, apoptosis//Zinc-finger of the MIZ type in Nse subunit//Ring finger domain//RING-H2 zinc finger//zinc-RING finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger) GO:0006915//GO:0016567 apoptotic process//protein ubiquitination GO:0008270//GO:0043169//GO:0046872//GO:0004842//GO:0005515 zinc ion binding//cation binding//metal ion binding//ubiquitin-protein transferase activity//protein binding GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.49350 BF_2 97.00 2.80 1734 189237799 XP_001814012.1 1866 4.8e-206 PREDICTED: polypeptide N-acetylgalactosaminyltransferase 35A [Tribolium castaneum]>gi|270008127|gb|EFA04575.1| PNR-like protein [Tribolium castaneum] -- -- -- -- -- K00710 GALNT polypeptide N-acetylgalactosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00710 Q8MVS5 1292 7.1e-141 Polypeptide N-acetylgalactosaminyltransferase 35A OS=Drosophila melanogaster GN=Pgant35A PE=1 SV=2 -- -- GO:0006486 protein glycosylation GO:0016757 transferase activity, transferring glycosyl groups GO:0016021//GO:0005794 integral component of membrane//Golgi apparatus KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.49351 BF_2 26.13 0.45 2722 642923664 XP_008193833.1 2846 0.0e+00 PREDICTED: acetylcholinesterase [Tribolium castaneum]>gi|270007708|gb|EFA04156.1| hypothetical protein TcasGA2_TC014402 [Tribolium castaneum] 160431938 EU086057.1 919 0 Alphitobius diaperinus strain Denmark-S acetylcholinesterase (AP-AChE) mRNA, partial cds K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 Q869C3 2087 7.3e-233 Acetylcholinesterase OS=Anopheles gambiae GN=Ace PE=3 SV=3 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787//GO:0004104 hydrolase activity//cholinesterase activity -- -- KOG4389 Acetylcholinesterase/Butyrylcholinesterase Cluster-8309.49352 BF_2 54.17 0.48 4983 91089905 XP_972496.1 1305 1.5e-140 PREDICTED: UDP-glucuronosyltransferase [Tribolium castaneum]>gi|270013659|gb|EFA10107.1| hypothetical protein TcasGA2_TC012286 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36513 593 2.3e-59 UDP-glucuronosyltransferase 2B14 OS=Oryctolagus cuniculus GN=UGT2B14 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016740//GO:0016758 transferase activity//transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.49353 BF_2 16.79 0.57 1512 642915949 XP_967806.3 982 1.3e-103 PREDICTED: protein halfway isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W568 475 3.4e-46 Protein halfway OS=Drosophila melanogaster GN=hfw PE=1 SV=3 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49354 BF_2 99.13 2.96 1687 478258020 ENN78158.1 607 4.5e-60 hypothetical protein YQE_05312, partial [Dendroctonus ponderosae] -- -- -- -- -- K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q7KRY6 484 3.4e-47 Nucleosomal histone kinase 1 OS=Drosophila melanogaster GN=ball PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.49358 BF_2 17.49 0.44 1962 478257079 ENN77242.1 541 2.4e-52 hypothetical protein YQE_06072, partial [Dendroctonus ponderosae] 642917441 XM_008192979.1 36 8.58624e-07 PREDICTED: Tribolium castaneum jerky protein homolog-like (LOC103312418), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49359 BF_2 134.97 2.85 2270 478257079 ENN77242.1 1174 1.1e-125 hypothetical protein YQE_06072, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.49360 BF_2 381.00 11.05 1730 762092937 XP_011428912.1 230 2.4e-16 PREDICTED: uncharacterized protein LOC105329380 isoform X3 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- P98088 142 1.6e-07 Mucin-5AC OS=Homo sapiens GN=MUC5AC PE=1 SV=4 PF09494 Slx4 endonuclease GO:0006260//GO:0006281//GO:0006308 DNA replication//DNA repair//DNA catabolic process GO:0017108 5'-flap endonuclease activity GO:0005634//GO:0033557 nucleus//Slx1-Slx4 complex -- -- Cluster-8309.49363 BF_2 76.00 0.80 4271 642921997 XP_008192975.1 1073 1.1e-113 PREDICTED: calcium uniporter protein, mitochondrial [Tribolium castaneum] 884952751 XM_013134023.1 63 1.8468e-21 PREDICTED: Esox lucius mitochondrial calcium uniporter (mcu), transcript variant X2, mRNA -- -- -- -- Q08BI9 672 1.4e-68 Calcium uniporter protein, mitochondrial OS=Danio rerio GN=mcu PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2966 Uncharacterized conserved protein Cluster-8309.49364 BF_2 104.19 1.91 2574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49365 BF_2 96.32 0.84 5106 642913543 XP_971895.2 790 8.2e-81 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 7.7e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF00097//PF06506//PF14634//PF00643//PF06003//PF02736 Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator//zinc-RING finger domain//B-box zinc finger//Survival motor neuron protein (SMN)//Myosin N-terminal SH3-like domain GO:0000160//GO:0006397 phosphorelay signal transduction system//mRNA processing GO:0005515//GO:0003677//GO:0005524//GO:0003723//GO:0046872//GO:0003774//GO:0000156//GO:0008270 protein binding//DNA binding//ATP binding//RNA binding//metal ion binding//motor activity//phosphorelay response regulator activity//zinc ion binding GO:0016459//GO:0005634//GO:0005737//GO:0005622 myosin complex//nucleus//cytoplasm//intracellular -- -- Cluster-8309.49368 BF_2 13.34 0.33 1959 642912548 XP_008200908.1 783 2.0e-80 PREDICTED: collagen and calcium-binding EGF domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXH8 363 4.2e-33 Collagen and calcium-binding EGF domain-containing protein 1 OS=Homo sapiens GN=CCBE1 PE=1 SV=1 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.49370 BF_2 207.84 1.66 5535 642939323 XP_969087.2 913 4.9e-95 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.81039e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF03876//PF01588 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Putative tRNA binding domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0000049 DNA-directed RNA polymerase activity//tRNA binding GO:0005730 nucleolus KOG2241 tRNA-binding protein Cluster-8309.49373 BF_2 333.68 6.06 2589 768419593 XP_011550521.1 1889 1.5e-208 PREDICTED: serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform [Plutella xylostella] 695538883 XM_009544325.1 56 8.67368e-18 Heterobasidion irregulare TC 32-1 hypothetical protein mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 A4FV68 1632 4.0e-180 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform OS=Bos taurus GN=PPP2R5E PE=1 SV=1 PF01603 Protein phosphatase 2A regulatory B subunit (B56 family) GO:0007165 signal transduction GO:0008601 protein phosphatase type 2A regulator activity GO:0000159 protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.49375 BF_2 541.23 3.30 7152 649572237 NP_001280538.1 2012 2.3e-222 5-hydroxytryptamine receptor [Tribolium castaneum]>gi|510960964|gb|AGN56420.1| serotonin receptor type 1 [Tribolium castaneum] 195584787 XM_002082150.1 80 1.09991e-30 Drosophila simulans GD11428 (Dsim\GD11428), mRNA K04153 HTR1 5-hydroxytryptamine receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04153 Q25190 1208 1.6e-130 5-hydroxytryptamine receptor OS=Heliothis virescens PE=2 SV=1 PF00974//PF00001 Rhabdovirus spike glycoprotein//7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0019031//GO:0016021 viral envelope//integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.49376 BF_2 131.23 1.21 4823 642935321 XP_008197967.1 172 3.6e-09 PREDICTED: 5-hydroxytryptamine receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49378 BF_2 44.99 1.99 1232 642933391 XP_008197397.1 350 2.1e-30 PREDICTED: cyclin-dependent kinase 2-associated protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49119 216 3.0e-16 Cyclin-dependent kinase 2-associated protein 1 OS=Mesocricetus auratus GN=CDK2AP1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4713 Cyclin-dependent kinase 2-associated protein Cluster-8309.49379 BF_2 935.92 8.27 5023 642936719 XP_008198552.1 2792 0.0e+00 PREDICTED: ATP-dependent RNA helicase DDX54 [Tribolium castaneum]>gi|270000966|gb|EEZ97413.1| hypothetical protein TcasGA2_TC011242 [Tribolium castaneum] 642936718 XM_008200330.1 214 2.49442e-105 PREDICTED: Tribolium castaneum ATP-dependent RNA helicase DDX54 (LOC660698), mRNA K14808 DDX54, DBP10 ATP-dependent RNA helicase DDX54/DBP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14808 Q8K4L0 1764 3.8e-195 ATP-dependent RNA helicase DDX54 OS=Mus musculus GN=Ddx54 PE=1 SV=1 PF08147//PF00974//PF15785//PF00227//PF00270 DBP10CT (NUC160) domain//Rhabdovirus spike glycoprotein//Serine/threonine-protein kinase smg-1//Proteasome subunit//DEAD/DEAH box helicase GO:0051603//GO:0009069//GO:0000184//GO:0016310 proteolysis involved in cellular protein catabolic process//serine family amino acid metabolic process//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//phosphorylation GO:0004298//GO:0016818//GO:0004674//GO:0003676//GO:0008026//GO:0003723//GO:0005524 threonine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//protein serine/threonine kinase activity//nucleic acid binding//ATP-dependent helicase activity//RNA binding//ATP binding GO:0005839//GO:0019031//GO:0005634 proteasome core complex//viral envelope//nucleus KOG0337 ATP-dependent RNA helicase Cluster-8309.49381 BF_2 105.65 0.76 6130 91091096 XP_968472.1 2668 1.7e-298 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58428 391 7.5e-36 ATP-binding cassette sub-family G member 8 OS=Rattus norvegicus GN=Abcg8 PE=2 SV=2 PF01061//PF00005 ABC-2 type transporter//ABC transporter -- -- GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.49382 BF_2 313.12 3.80 3730 91091096 XP_968472.1 1886 4.9e-208 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270013147|gb|EFA09595.1| hypothetical protein TcasGA2_TC011713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58428 301 1.2e-25 ATP-binding cassette sub-family G member 8 OS=Rattus norvegicus GN=Abcg8 PE=2 SV=2 PF05297//PF00005//PF01061 Herpesvirus latent membrane protein 1 (LMP1)//ABC transporter//ABC-2 type transporter GO:0006200//GO:0019087 obsolete ATP catabolic process//transformation of host cell by virus GO:0016887//GO:0005524 ATPase activity//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.49383 BF_2 601.52 13.62 2135 478253336 ENN73697.1 702 5.5e-71 hypothetical protein YQE_09694, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0W2W6 433 3.5e-41 Protein maelstrom homolog OS=Culex quinquefasciatus GN=mael PE=3 SV=1 PF02438 Late 100kD protein GO:0019060 intracellular transport of viral protein in host cell -- -- -- -- -- -- Cluster-8309.49385 BF_2 21.36 0.38 2615 642934168 XP_008199635.1 1855 1.4e-204 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.89664e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 O95352 1286 5.3e-140 Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1 PF13241//PF00899//PF02826 Putative NAD(P)-binding//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0006779//GO:0055114//GO:0019354 porphyrin-containing compound biosynthetic process//oxidation-reduction process//siroheme biosynthetic process GO:0008641//GO:0051287//GO:0043115 small protein activating enzyme activity//NAD binding//precorrin-2 dehydrogenase activity -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.49386 BF_2 147.48 3.46 2069 189236439 XP_001814289.1 886 2.5e-92 PREDICTED: uncharacterized protein LOC100142575 [Tribolium castaneum]>gi|270005928|gb|EFA02376.1| hypothetical protein TcasGA2_TC008051 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08332 Calcium/calmodulin dependent protein kinase II association domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005516//GO:0004683 calmodulin binding//calmodulin-dependent protein kinase activity -- -- -- -- Cluster-8309.49387 BF_2 104.75 0.52 8736 642938612 XP_008199865.1 1750 6.8e-192 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] 462373247 APGK01024812.1 79 4.8367e-30 Dendroctonus ponderosae Seq01024822, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF05366//PF00435//PF10541//PF01388 Sarcolipin//Spectrin repeat//Nuclear envelope localisation domain//ARID/BRIGHT DNA binding domain -- -- GO:0003677//GO:0005515//GO:0030234 DNA binding//protein binding//enzyme regulator activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.49389 BF_2 420.37 2.55 7185 642938612 XP_008199865.1 2583 1.4e-288 PREDICTED: uncharacterized protein LOC655974, partial [Tribolium castaneum] 462373247 APGK01024812.1 79 3.97434e-30 Dendroctonus ponderosae Seq01024822, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF00435//PF01388//PF10541 Spectrin repeat//ARID/BRIGHT DNA binding domain//Nuclear envelope localisation domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.49391 BF_2 280.11 1.44 8430 642916934 XP_008199560.1 2574 1.8e-287 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] 642916933 XM_008201338.1 374 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase HSL1 (LOC660568), mRNA K08853 AAK AP2-associated kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08853 F1MH24 1145 3.8e-123 AP2-associated protein kinase 1 OS=Bos taurus GN=AAK1 PE=1 SV=2 PF00069//PF07714//PF08925 Protein kinase domain//Protein tyrosine kinase//Domain of Unknown Function (DUF1907) GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005634 nucleus KOG1989 ARK protein kinase family Cluster-8309.49392 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.49393 BF_2 68.00 4.42 931 270013462 EFA09910.1 708 4.8e-72 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09426 216 2.2e-16 2-hydroxyacylsphingosine 1-beta-galactosyltransferase OS=Rattus norvegicus GN=Ugt8 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.49394 BF_2 146.00 4.36 1687 270013462 EFA09910.1 1288 4.9e-139 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q91280 529 2.1e-52 UDP-glucuronosyltransferase (Fragment) OS=Pleuronectes platessa GN=ugt3 PE=2 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.49395 BF_2 3.00 0.72 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49396 BF_2 630.14 12.93 2326 642917609 XP_008191278.1 1425 8.7e-155 PREDICTED: U3 small nucleolar RNA-associated protein 6 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VCY6 452 2.4e-43 U3 small nucleolar RNA-associated protein 6 homolog OS=Mus musculus GN=Utp6 PE=2 SV=1 PF05843 Suppressor of forked protein (Suf) GO:0006397 mRNA processing -- -- GO:0005634 nucleus KOG2396 HAT (Half-A-TPR) repeat-containing protein Cluster-8309.49399 BF_2 15.57 0.45 1724 91084617 XP_974511.1 940 1.1e-98 PREDICTED: serine/threonine-protein kinase 16 [Tribolium castaneum]>gi|270008645|gb|EFA05093.1| hypothetical protein TcasGA2_TC015191 [Tribolium castaneum] -- -- -- -- -- K08856 STK16 serine/threonine kinase 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08856 P57760 453 1.4e-43 Serine/threonine-protein kinase 16 OS=Rattus norvegicus GN=Stk16 PE=2 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG1989 ARK protein kinase family Cluster-8309.49400 BF_2 118.29 3.60 1663 91084617 XP_974511.1 1367 3.3e-148 PREDICTED: serine/threonine-protein kinase 16 [Tribolium castaneum]>gi|270008645|gb|EFA05093.1| hypothetical protein TcasGA2_TC015191 [Tribolium castaneum] -- -- -- -- -- K08856 STK16 serine/threonine kinase 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08856 P57760 626 1.1e-63 Serine/threonine-protein kinase 16 OS=Rattus norvegicus GN=Stk16 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG2345 Serine/threonine protein kinase/TGF-beta stimulated factor Cluster-8309.49402 BF_2 45.14 1.32 1720 91084617 XP_974511.1 1070 9.4e-114 PREDICTED: serine/threonine-protein kinase 16 [Tribolium castaneum]>gi|270008645|gb|EFA05093.1| hypothetical protein TcasGA2_TC015191 [Tribolium castaneum] -- -- -- -- -- K08856 STK16 serine/threonine kinase 16 http://www.genome.jp/dbget-bin/www_bget?ko:K08856 P57760 484 3.5e-47 Serine/threonine-protein kinase 16 OS=Rattus norvegicus GN=Stk16 PE=2 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG1989 ARK protein kinase family Cluster-8309.49404 BF_2 479.01 22.37 1183 91082921 XP_972710.1 1216 7.6e-131 PREDICTED: annulin [Tribolium castaneum]>gi|270007059|gb|EFA03507.1| hypothetical protein TcasGA2_TC013508 [Tribolium castaneum] 462337062 APGK01037684.1 46 1.41219e-12 Dendroctonus ponderosae Seq01037694, whole genome shotgun sequence K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 P52183 841 9.6e-89 Annulin OS=Schistocerca americana PE=2 SV=1 PF00868 Transglutaminase family GO:0018149 peptide cross-linking -- -- -- -- -- -- Cluster-8309.49405 BF_2 101.87 1.78 2679 91090986 XP_974863.1 2692 1.2e-301 PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936123|ref|XP_008198309.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936125|ref|XP_008198310.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|270013188|gb|EFA09636.1| hypothetical protein TcasGA2_TC011759 [Tribolium castaneum] 642936121 XM_969770.3 61 1.49093e-20 PREDICTED: Tribolium castaneum ubiquitin thioesterase trabid (LOC663735), transcript variant X1, mRNA K11862 ZRANB1, TRABID ubiquitin thioesterase ZRANB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11862 Q9VH90 1856 4.4e-206 Ubiquitin thioesterase trabid OS=Drosophila melanogaster GN=trbd PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG4345 NF-kappa B regulator AP20/Cezanne Cluster-8309.49406 BF_2 13.16 0.37 1758 546676192 ERL87259.1 150 4.6e-07 hypothetical protein D910_04656 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01401 Angiotensin-converting enzyme GO:0006508 proteolysis GO:0008241//GO:0008237 peptidyl-dipeptidase activity//metallopeptidase activity GO:0016020 membrane -- -- Cluster-8309.49407 BF_2 719.50 4.06 7704 642928738 XP_008199761.1 3549 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|642928740|ref|XP_008199762.1| PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 3 [Tribolium castaneum]>gi|270009769|gb|EFA06217.1| hypothetical protein TcasGA2_TC009066 [Tribolium castaneum] 642928739 XM_008201540.1 59 5.59299e-19 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 4 regulatory subunit 3 (LOC663105), transcript variant X2, mRNA K17491 SMEK, PPP4R3 protein phosphatase 4 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17491 Q9VFS5 2688 4.2e-302 Serine/threonine-protein phosphatase 4 regulatory subunit 3 OS=Drosophila melanogaster GN=flfl PE=1 SV=4 PF00638 RanBP1 domain GO:0046907 intracellular transport -- -- -- -- KOG2175 Protein predicted to be involved in carbohydrate metabolism Cluster-8309.49408 BF_2 104.47 6.28 983 642917000 XP_008199589.1 252 3.8e-19 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49409 BF_2 71.90 3.37 1179 270009226 EFA05674.1 966 7.4e-102 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXL6 334 5.9e-30 SID1 transmembrane family member 1 OS=Homo sapiens GN=SIDT1 PE=2 SV=2 PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.4941 BF_2 38.01 0.50 3488 270008685 EFA05133.1 1253 1.2e-134 hypothetical protein TcasGA2_TC015248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00822//PF01699//PF09258 PMP-22/EMP/MP20/Claudin family//Sodium/calcium exchanger protein//Glycosyl transferase family 64 domain GO:0055085//GO:0015012//GO:0006024 transmembrane transport//heparan sulfate proteoglycan biosynthetic process//glycosaminoglycan biosynthetic process -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49412 BF_2 61.42 2.08 1522 270009226 EFA05674.1 986 4.6e-104 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXL6 466 3.7e-45 SID1 transmembrane family member 1 OS=Homo sapiens GN=SIDT1 PE=2 SV=2 PF13965 dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49414 BF_2 106.39 3.09 1726 270009226 EFA05674.1 1253 5.7e-135 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NXL6 664 4.7e-68 SID1 transmembrane family member 1 OS=Homo sapiens GN=SIDT1 PE=2 SV=2 PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49419 BF_2 50.00 0.38 5862 642928556 XP_008195374.1 702 1.5e-70 PREDICTED: serine protease easter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 413 2.0e-38 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.4942 BF_2 2.00 0.39 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49420 BF_2 2.00 0.53 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01096 Transcription factor S-II (TFIIS) GO:0006351 transcription, DNA-templated GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.49421 BF_2 171.58 5.91 1502 91078286 XP_971953.1 1058 2.0e-112 PREDICTED: negative elongation factor E [Tribolium castaneum]>gi|270003949|gb|EFA00397.1| hypothetical protein TcasGA2_TC003247 [Tribolium castaneum] -- -- -- -- -- K15182 RDBP, NELFE negative elongation factor E http://www.genome.jp/dbget-bin/www_bget?ko:K15182 P92204 626 1.0e-63 Negative elongation factor E OS=Drosophila melanogaster GN=Nelf-E PE=1 SV=1 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0000166//GO:0003676 RNA binding//nucleotide binding//nucleic acid binding -- -- KOG0123 Polyadenylate-binding protein (RRM superfamily) Cluster-8309.49422 BF_2 113.23 1.35 3802 91093755 XP_969513.1 2086 3.2e-231 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 [Tribolium castaneum]>gi|270012977|gb|EFA09425.1| hypothetical protein TcasGA2_TC010636 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 O15254 1438 1.8e-157 Peroxisomal acyl-coenzyme A oxidase 3 OS=Homo sapiens GN=ACOX3 PE=1 SV=2 PF01756//PF07716//PF07544//PF05139//PF00441//PF02770//PF00107 Acyl-CoA oxidase//Basic region leucine zipper//RNA polymerase II transcription mediator complex subunit 9//Erythromycin esterase//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain//Zinc-binding dehydrogenase GO:0006637//GO:0006118//GO:0006355//GO:0006357//GO:0055114//GO:0006635//GO:0046677//GO:0006631 acyl-CoA metabolic process//obsolete electron transport//regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//oxidation-reduction process//fatty acid beta-oxidation//response to antibiotic//fatty acid metabolic process GO:0003995//GO:0043565//GO:0003700//GO:0016627//GO:0001104//GO:0003997 acyl-CoA dehydrogenase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity, acting on the CH-CH group of donors//RNA polymerase II transcription cofactor activity//acyl-CoA oxidase activity GO:0016592//GO:0005777//GO:0005667 mediator complex//peroxisome//transcription factor complex KOG0135 Pristanoyl-CoA/acyl-CoA oxidase Cluster-8309.49424 BF_2 120.04 3.16 1874 345480784 XP_001605371.2 299 2.6e-24 PREDICTED: GTP cyclohydrolase 1 isoform X2 [Nasonia vitripennis] 768436468 XM_011561420.1 91 2.18359e-37 PREDICTED: Plutella xylostella GTP cyclohydrolase 1 (LOC105390169), transcript variant X2, mRNA K01495 GCH1, folE GTP cyclohydrolase I http://www.genome.jp/dbget-bin/www_bget?ko:K01495 P48596 283 7.7e-24 GTP cyclohydrolase 1 OS=Drosophila melanogaster GN=Pu PE=2 SV=3 -- -- -- -- -- -- -- -- KOG2698 GTP cyclohydrolase I Cluster-8309.49426 BF_2 13.00 0.52 1330 91093827 XP_966784.1 445 2.2e-41 PREDICTED: proline-rich protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49427 BF_2 113.19 1.65 3149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49428 BF_2 8.00 0.54 910 478254618 ENN74861.1 380 5.1e-34 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 -- -- -- -- PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.49429 BF_2 562.49 16.10 1749 478254618 ENN74861.1 748 2.1e-76 hypothetical protein YQE_08631, partial [Dendroctonus ponderosae] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 343 7.9e-31 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF06687//PF00230//PF07043 SUR7/PalI family//Major intrinsic protein//Protein of unknown function (DUF1328) GO:0006810 transport GO:0005215 transporter activity GO:0005886//GO:0016020 plasma membrane//membrane -- -- Cluster-8309.49430 BF_2 7.32 0.52 872 642923081 XP_970728.2 443 2.4e-41 PREDICTED: aquaporin NIP1-2-like [Tribolium castaneum] -- -- -- -- -- K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q25074 367 6.5e-34 Aquaporin OS=Haematobia irritans exigua PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.49431 BF_2 340.30 34.56 699 478255840 ENN76048.1 300 7.4e-25 hypothetical protein YQE_07421, partial [Dendroctonus ponderosae]>gi|546680467|gb|ERL90733.1| hypothetical protein D910_08080 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16692 Folliculin C-terminal domain GO:0043087 regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.49433 BF_2 610.75 8.33 3356 91090986 XP_974863.1 2803 0.0e+00 PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936123|ref|XP_008198309.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|642936125|ref|XP_008198310.1| PREDICTED: ubiquitin thioesterase trabid [Tribolium castaneum]>gi|270013188|gb|EFA09636.1| hypothetical protein TcasGA2_TC011759 [Tribolium castaneum] 642936121 XM_969770.3 59 2.42267e-19 PREDICTED: Tribolium castaneum ubiquitin thioesterase trabid (LOC663735), transcript variant X1, mRNA K11862 ZRANB1, TRABID ubiquitin thioesterase ZRANB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11862 Q9VH90 1920 2.1e-213 Ubiquitin thioesterase trabid OS=Drosophila melanogaster GN=trbd PE=1 SV=1 PF00641 Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG4345 NF-kappa B regulator AP20/Cezanne Cluster-8309.49435 BF_2 1827.00 20.19 4073 189235802 XP_976325.2 307 6.7e-25 PREDICTED: DNA ligase 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49436 BF_2 19.51 1.70 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49437 BF_2 7.77 0.31 1328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49438 BF_2 84.00 0.92 4089 546685504 ERL95002.1 782 5.6e-80 hypothetical protein D910_12274 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IIG7 182 8.6e-12 Uncharacterized protein PF11_0207 OS=Plasmodium falciparum (isolate 3D7) GN=PF11_0207 PE=4 SV=2 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.4944 BF_2 63.12 3.28 1092 642922841 XP_001813804.2 546 3.4e-53 PREDICTED: uncharacterized protein LOC100141768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05297//PF03694 Herpesvirus latent membrane protein 1 (LMP1)//Erg28 like protein GO:0019087 transformation of host cell by virus -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49443 BF_2 31.72 3.00 730 478252829 ENN73218.1 578 4.5e-57 hypothetical protein YQE_10115, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49444 BF_2 1001.14 12.21 3716 589094703 AHK59785.1 1404 3.8e-152 major facilitator superfamily protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZU13 144 2.0e-07 Protein spinster homolog 1 OS=Danio rerio GN=spns1 PE=2 SV=1 PF01220//PF00083//PF07690 Dehydroquinase class II//Sugar (and other) transporter//Major Facilitator Superfamily GO:0006571//GO:0000162//GO:0009094//GO:0055085 tyrosine biosynthetic process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process//transmembrane transport GO:0003855//GO:0022857 3-dehydroquinate dehydratase activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.49445 BF_2 42.00 7.17 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49446 BF_2 93.00 21.13 471 307168739 EFN61742.1 207 3.0e-14 hypothetical protein EAG_13055, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49447 BF_2 1.00 29.91 208 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49448 BF_2 74.63 0.65 5089 642917330 XP_008199256.1 2195 9.9e-244 PREDICTED: kazrin isoform X4 [Tribolium castaneum] 642917329 XM_008201034.1 314 6.50108e-161 PREDICTED: Tribolium castaneum kazrin (LOC658072), transcript variant X4, mRNA -- -- -- -- Q674X7 600 3.6e-60 Kazrin OS=Homo sapiens GN=KAZN PE=1 SV=2 PF00536//PF07647//PF02183//PF12285//PF09482 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//Homeobox associated leucine zipper//Protein of unknown function (DUF3621)//Bacterial type III secretion apparatus protein (OrgA_MxiK) GO:0006355//GO:0009405 regulation of transcription, DNA-templated//pathogenesis GO:0003700//GO:0004252//GO:0043565//GO:0070008//GO:0005515 transcription factor activity, sequence-specific DNA binding//serine-type endopeptidase activity//sequence-specific DNA binding//serine-type exopeptidase activity//protein binding GO:0005667 transcription factor complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.49451 BF_2 169.69 1.30 5730 270007165 EFA03613.1 1428 9.7e-155 hypothetical protein TcasGA2_TC013701 [Tribolium castaneum] 642922583 XM_008195015.1 341 7.17194e-176 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X3, mRNA -- -- -- -- P55197 839 7.9e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG0956 PHD finger protein AF10 Cluster-8309.49452 BF_2 44.00 0.92 2298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49453 BF_2 5.00 1.93 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49454 BF_2 3.00 0.49 541 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49455 BF_2 878.81 6.46 5982 642916405 XP_008191009.1 3474 0.0e+00 PREDICTED: GATA zinc finger domain-containing protein 14 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DBJ3 302 1.5e-25 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 OS=Mus musculus GN=Baiap2l1 PE=1 SV=1 PF00018//PF14604//PF08397 SH3 domain//Variant SH3 domain//IRSp53/MIM homology domain GO:0007009 plasma membrane organization GO:0005515 protein binding -- -- -- -- Cluster-8309.49456 BF_2 61.17 1.51 1987 270003897 EFA00345.1 1623 8.2e-178 hypothetical protein TcasGA2_TC003184 [Tribolium castaneum] 766920220 XM_011506269.1 107 2.9561e-46 PREDICTED: Ceratosolen solmsi marchali dosage compensation regulator (LOC105367527), mRNA K13184 DHX9 ATP-dependent RNA helicase A http://www.genome.jp/dbget-bin/www_bget?ko:K13184 P24785 1205 9.9e-131 Dosage compensation regulator OS=Drosophila melanogaster GN=mle PE=2 SV=2 PF00437//PF00270//PF03060//PF03368 Type II/IV secretion system protein//DEAD/DEAH box helicase//Nitronate monooxygenase//Dicer dimerisation domain GO:0006810//GO:0006807//GO:0055114//GO:0051252 transport//nitrogen compound metabolic process//oxidation-reduction process//regulation of RNA metabolic process GO:0005524//GO:0018580//GO:0003676//GO:0016891 ATP binding//nitronate monooxygenase activity//nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG0921 Dosage compensation complex, subunit MLE Cluster-8309.49458 BF_2 6.00 0.47 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49461 BF_2 136.44 3.49 1922 189239542 XP_001816493.1 505 3.5e-48 PREDICTED: uncharacterized protein LOC100141605 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49462 BF_2 35.00 3.83 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49464 BF_2 1066.49 4.99 9219 91076832 XP_974636.1 3950 0.0e+00 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] 642913068 XM_008203154.1 224 1.26754e-110 PREDICTED: Tribolium castaneum mitogen-activated protein kinase kinase kinase 4 (LOC663503), transcript variant X2, mRNA K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 Q9Y6R4 854 2.3e-89 Mitogen-activated protein kinase kinase kinase 4 OS=Homo sapiens GN=MAP3K4 PE=1 SV=2 PF02744//PF07714//PF00069 Galactose-1-phosphate uridyl transferase, C-terminal domain//Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009117//GO:0006012 protein phosphorylation//nucleotide metabolic process//galactose metabolic process GO:0008108//GO:0004672//GO:0005524//GO:0000166 UDP-glucose:hexose-1-phosphate uridylyltransferase activity//protein kinase activity//ATP binding//nucleotide binding -- -- KOG4645 MAPKKK (MAP kinase kinase kinase) SSK2 and related serine/threonine protein kinases Cluster-8309.49465 BF_2 229.11 6.24 1822 478252220 ENN72648.1 669 3.1e-67 hypothetical protein YQE_10746, partial [Dendroctonus ponderosae] 645003522 XM_008214370.1 95 1.26802e-39 PREDICTED: Nasonia vitripennis high affinity copper uptake protein 1 (LOC100122867), transcript variant X3, mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 340 1.8e-30 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane KOG3386 Copper transporter Cluster-8309.49466 BF_2 10.00 1.10 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00957//PF05434 Synaptobrevin//TMEM9 GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49467 BF_2 13.98 1.32 729 270007921 EFA04369.1 175 2.4e-10 hypothetical protein TcasGA2_TC014667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49469 BF_2 152.86 3.80 1972 189234241 XP_976116.2 673 1.2e-67 PREDICTED: high affinity copper uptake protein 1 isoform X2 [Tribolium castaneum] 645003520 XM_008214369.1 86 1.38422e-34 PREDICTED: Nasonia vitripennis high affinity copper uptake protein 1 (LOC100122867), transcript variant X2, mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 362 5.6e-33 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145 Ctr copper transporter family GO:0006825//GO:0035434 copper ion transport//copper ion transmembrane transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane KOG3386 Copper transporter Cluster-8309.49470 BF_2 46.94 0.75 2921 642927770 XP_008195398.1 727 9.5e-74 PREDICTED: uncharacterized protein LOC103313579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JM12 145 1.2e-07 Multiple epidermal growth factor-like domains protein 10 OS=Xenopus tropicalis GN=megf10 PE=2 SV=1 PF02018 Carbohydrate binding domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds -- -- -- -- Cluster-8309.49471 BF_2 75.35 0.53 6258 91087319 XP_975585.1 1392 1.6e-150 PREDICTED: solute carrier family 46 member 3-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q5F4B8 257 2.6e-20 Solute carrier family 46 member 3 OS=Gallus gallus GN=SLC46A3 PE=2 SV=1 PF00608//PF02285//PF07690//PF04023 Adenoviral fibre protein (repeat/shaft region)//Cytochrome oxidase c subunit VIII//Major Facilitator Superfamily//FeoA domain GO:0055085//GO:0006123//GO:0009405//GO:0019062//GO:0015992//GO:0007155 transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//pathogenesis//virion attachment to host cell//proton transport//cell adhesion GO:0046914//GO:0004129 transition metal ion binding//cytochrome-c oxidase activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.49473 BF_2 145.54 11.36 823 91081479 XP_974351.1 873 3.1e-91 PREDICTED: dynactin subunit 5 [Tribolium castaneum]>gi|270006145|gb|EFA02593.1| hypothetical protein TcasGA2_TC008312 [Tribolium castaneum] 642920959 XM_969258.2 155 2.4797e-73 PREDICTED: Tribolium castaneum dynactin subunit 5 (LOC663200), mRNA K10427 DCTN5 dynactin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10427 Q5R559 670 4.5e-69 Dynactin subunit 5 OS=Pongo abelii GN=DCTN5 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772//GO:0016740 transferase activity, transferring phosphorus-containing groups//transferase activity -- -- KOG3121 Dynactin, subunit p25 Cluster-8309.49474 BF_2 6.79 0.83 630 91081479 XP_974351.1 676 1.7e-68 PREDICTED: dynactin subunit 5 [Tribolium castaneum]>gi|270006145|gb|EFA02593.1| hypothetical protein TcasGA2_TC008312 [Tribolium castaneum] 642920959 XM_969258.2 128 1.91331e-58 PREDICTED: Tribolium castaneum dynactin subunit 5 (LOC663200), mRNA K10427 DCTN5 dynactin 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10427 Q5R559 513 5.5e-51 Dynactin subunit 5 OS=Pongo abelii GN=DCTN5 PE=2 SV=1 PF07959 L-fucokinase -- -- GO:0016772//GO:0016740 transferase activity, transferring phosphorus-containing groups//transferase activity -- -- KOG3121 Dynactin, subunit p25 Cluster-8309.49475 BF_2 520.04 6.74 3514 91090862 XP_972769.1 1643 6.9e-180 PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935950|ref|XP_008198243.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|642935952|ref|XP_008198244.1| PREDICTED: COP9 signalosome complex subunit 5 [Tribolium castaneum]>gi|270013240|gb|EFA09688.1| hypothetical protein TcasGA2_TC011816 [Tribolium castaneum] 196009166 XM_002114413.1 132 6.6682e-60 Trichoplax adhaerens hypothetical protein, mRNA K09613 COPS5, CSN5 COP9 signalosome complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09613 O35864 1371 9.9e-150 COP9 signalosome complex subunit 5 OS=Mus musculus GN=Cops5 PE=1 SV=3 PF04479//PF03083//PF01040//PF01398 RTA1 like protein//Sugar efflux transporter for intercellular exchange//UbiA prenyltransferase family//JAB1/Mov34/MPN/PAD-1 ubiquitin protease GO:0006950 response to stress GO:0004659//GO:0005515 prenyltransferase activity//protein binding GO:0016021 integral component of membrane KOG1554 COP9 signalosome, subunit CSN5 Cluster-8309.49477 BF_2 150.38 1.10 5987 642911239 XP_008199721.1 3998 0.0e+00 PREDICTED: IQ motif and SEC7 domain-containing protein 1 isoform X1 [Tribolium castaneum] 641661643 XM_001945108.3 182 1.82988e-87 PREDICTED: Acyrthosiphon pisum IQ motif and SEC7 domain-containing protein 1 (LOC100162626), transcript variant X2, mRNA K12495 IQSEC IQ motif and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12495 Q6DN90 1206 2.3e-130 IQ motif and SEC7 domain-containing protein 1 OS=Homo sapiens GN=IQSEC1 PE=1 SV=1 PF01369//PF00612 Sec7 domain//IQ calmodulin-binding motif GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005515//GO:0005086 protein binding//ARF guanyl-nucleotide exchange factor activity -- -- KOG0931 Predicted guanine nucleotide exchange factor, contains Sec7 domain Cluster-8309.49484 BF_2 477.24 34.73 862 332373702 AEE61992.1 351 1.1e-30 unknown [Dendroctonus ponderosae]>gi|478250661|gb|ENN71153.1| hypothetical protein YQE_12084, partial [Dendroctonus ponderosae]>gi|546677245|gb|ERL88114.1| hypothetical protein D910_05503 [Dendroctonus ponderosae] -- -- -- -- -- K05357 VKORC1 vitamin-K-epoxide reductase (warfarin-sensitive) http://www.genome.jp/dbget-bin/www_bget?ko:K05357 Q8N0U8 229 6.4e-18 Vitamin K epoxide reductase complex subunit 1-like protein 1 OS=Homo sapiens GN=VKORC1L1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49486 BF_2 498.46 3.27 6670 270006862 EFA03310.1 2203 1.5e-244 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q96IG2 1483 1.9e-162 F-box/LRR-repeat protein 20 OS=Homo sapiens GN=FBXL20 PE=1 SV=2 PF02126//PF12937//PF13516//PF15966//PF00646//PF00560//PF13855//PF00152 Phosphotriesterase family//F-box-like//Leucine Rich repeat//F-box//F-box domain//Leucine Rich Repeat//Leucine rich repeat//tRNA synthetases class II (D, K and N) GO:0009056//GO:0006418 catabolic process//tRNA aminoacylation for protein translation GO:0005515//GO:0004812//GO:0000166//GO:0008270//GO:0005524 protein binding//aminoacyl-tRNA ligase activity//nucleotide binding//zinc ion binding//ATP binding -- -- KOG1947 Leucine rich repeat proteins, some proteins contain F-box Cluster-8309.49490 BF_2 127.40 5.32 1289 91090252 XP_969934.1 408 4.1e-37 PREDICTED: mitochondrial import receptor subunit TOM22 homolog [Tribolium castaneum]>gi|270013781|gb|EFA10229.1| hypothetical protein TcasGA2_TC012425 [Tribolium castaneum] -- -- -- -- -- K17769 TOM22 mitochondrial import receptor subunit TOM22 http://www.genome.jp/dbget-bin/www_bget?ko:K17769 Q9CPQ3 236 1.5e-18 Mitochondrial import receptor subunit TOM22 homolog OS=Mus musculus GN=Tomm22 PE=2 SV=3 PF04281 Mitochondrial import receptor subunit Tom22 GO:0006886 intracellular protein transport -- -- GO:0005741 mitochondrial outer membrane KOG4111 Translocase of outer mitochondrial membrane complex, subunit TOM22 Cluster-8309.49491 BF_2 26.00 0.85 1563 478256534 ENN76718.1 642 3.6e-64 hypothetical protein YQE_06783, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q0VAW7 348 1.9e-31 Zinc finger protein 112 OS=Mus musculus GN=Znf112 PE=2 SV=2 PF00096//PF13465//PF00130//PF02892//PF13912//PF05191//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//BED zinc finger//C2H2-type zinc finger//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0046034//GO:0006144//GO:0035556 ATP metabolic process//purine nucleobase metabolic process//intracellular signal transduction GO:0046872//GO:0004017//GO:0003677 metal ion binding//adenylate kinase activity//DNA binding -- -- -- -- Cluster-8309.49492 BF_2 26.75 0.43 2875 91084671 XP_966504.1 791 3.5e-81 PREDICTED: lambda-crystallin [Tribolium castaneum]>gi|270008625|gb|EFA05073.1| hypothetical protein TcasGA2_TC015170 [Tribolium castaneum] -- -- -- -- -- K13247 CRYL1 L-gulonate 3-dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K13247 P14755 502 4.7e-49 Lambda-crystallin OS=Oryctolagus cuniculus GN=CRYL1 PE=1 SV=3 PF02737//PF03446//PF00725//PF12592 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, C-terminal domain//Protein of unknown function (DUF3763) GO:0006633//GO:0018874//GO:0006098//GO:0006552//GO:0006631//GO:0006574//GO:0006550//GO:0006554//GO:0055114//GO:0019521//GO:0006568 fatty acid biosynthetic process//benzoate metabolic process//pentose-phosphate shunt//leucine catabolic process//fatty acid metabolic process//valine catabolic process//isoleucine catabolic process//lysine catabolic process//oxidation-reduction process//D-gluconate metabolic process//tryptophan metabolic process GO:0016491//GO:0016820//GO:0070403//GO:0003857//GO:0004616 oxidoreductase activity//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//NAD+ binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity -- -- KOG2305 3-hydroxyacyl-CoA dehydrogenase Cluster-8309.49493 BF_2 34.54 0.71 2314 642915206 XP_008190520.1 275 1.9e-21 PREDICTED: gelsolin-related protein of 125 kDa isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49495 BF_2 2.00 0.48 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00937//PF04732//PF01788 Coronavirus nucleocapsid protein//Intermediate filament head (DNA binding) region//PsbJ GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523//GO:0019013//GO:0005882 membrane//photosystem II reaction center//photosystem II//viral nucleocapsid//intermediate filament -- -- Cluster-8309.49500 BF_2 275.41 2.85 4332 270014937 EFA11385.1 608 8.9e-60 hypothetical protein TcasGA2_TC011545 [Tribolium castaneum] -- -- -- -- -- K10694 ZNRF1_2 E3 ubiquitin-protein ligase ZNRF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K10694 Q8NHG8 395 1.8e-36 E3 ubiquitin-protein ligase ZNRF2 OS=Homo sapiens GN=ZNRF2 PE=1 SV=1 PF01612//PF15926//PF13639//PF14634//PF12906//PF17123//PF12678//PF00097 3'-5' exonuclease//E3 ubiquitin-protein ligase RNF220//Ring finger domain//zinc-RING finger domain//RING-variant domain//RING-like zinc finger//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0090263//GO:0016567//GO:0006139 positive regulation of canonical Wnt signaling pathway//protein ubiquitination//nucleobase-containing compound metabolic process GO:0005515//GO:0003676//GO:0008408//GO:0008270//GO:0046872 protein binding//nucleic acid binding//3'-5' exonuclease activity//zinc ion binding//metal ion binding -- -- KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.49507 BF_2 7.00 0.74 684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49508 BF_2 472.41 8.61 2583 546684930 ERL94512.1 2755 5.8e-309 hypothetical protein D910_11789 [Dendroctonus ponderosae] 641669724 XM_001950701.3 53 4.02599e-16 PREDICTED: Acyrthosiphon pisum myotubularin-related protein 6 (LOC100169408), transcript variant X2, mRNA K18083 MTMR6_7_8 myotubularin-related protein 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K18083 Q5F452 1701 4.0e-188 Myotubularin-related protein 8 OS=Gallus gallus GN=MTMR8 PE=2 SV=1 PF01363//PF00782//PF00102//PF13639 FYVE zinc finger//Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase//Ring finger domain GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0008270//GO:0008138//GO:0005515//GO:0004725//GO:0046872 zinc ion binding//protein tyrosine/serine/threonine phosphatase activity//protein binding//protein tyrosine phosphatase activity//metal ion binding -- -- KOG1089 Myotubularin-related phosphatidylinositol 3-phosphate 3-phosphatase MTM6 Cluster-8309.49510 BF_2 42.13 4.31 696 478252124 ENN72555.1 292 6.2e-24 hypothetical protein YQE_10895, partial [Dendroctonus ponderosae] -- -- -- -- -- K18747 SXL protein sex-lethal http://www.genome.jp/dbget-bin/www_bget?ko:K18747 Q15717 170 3.6e-11 ELAV-like protein 1 OS=Homo sapiens GN=ELAVL1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0145 RNA-binding protein ELAV/HU (RRM superfamily) Cluster-8309.49512 BF_2 138.94 3.67 1869 91082933 XP_972996.1 1070 1.0e-113 PREDICTED: uncharacterized protein LOC661762 [Tribolium castaneum]>gi|270007056|gb|EFA03504.1| hypothetical protein TcasGA2_TC013505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49514 BF_2 204.68 1.71 5294 546680010 ERL90372.1 1094 4.8e-116 hypothetical protein D910_07721 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6VMQ6 269 9.1e-22 Activating transcription factor 7-interacting protein 1 OS=Homo sapiens GN=ATF7IP PE=1 SV=3 PF06156//PF16794//PF17060 Protein of unknown function (DUF972)//Fibronectin-III type domain//Monopolar spindle protein 2 GO:0030474//GO:0071988//GO:0006260 spindle pole body duplication//protein localization to spindle pole body//DNA replication GO:0005515 protein binding -- -- -- -- Cluster-8309.4952 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49520 BF_2 149.23 0.82 7874 859132808 AKO63318.1 2842 0.0e+00 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 2206 3.3e-246 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF14634//PF00643//PF00628//PF17123//PF00283//PF02460//PF02932//PF00368//PF13639 zinc-RING finger domain//B-box zinc finger//PHD-finger//RING-like zinc finger//Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits//Patched family//Neurotransmitter-gated ion-channel transmembrane region//Hydroxymethylglutaryl-coenzyme A reductase//Ring finger domain GO:0015979//GO:0007165//GO:0006811//GO:0015936//GO:0006694//GO:0055114 photosynthesis//signal transduction//ion transport//coenzyme A metabolic process//steroid biosynthetic process//oxidation-reduction process GO:0005515//GO:0050662//GO:0008158//GO:0004420//GO:0008270 protein binding//coenzyme binding//hedgehog receptor activity//hydroxymethylglutaryl-CoA reductase (NADPH) activity//zinc ion binding GO:0005622//GO:0016020 intracellular//membrane KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.49521 BF_2 36.82 0.59 2883 642923308 XP_008193697.1 1923 1.9e-212 PREDICTED: T-box transcription factor TBX20-like isoform X1 [Tribolium castaneum]>gi|642923310|ref|XP_008193698.1| PREDICTED: T-box transcription factor TBX20-like isoform X1 [Tribolium castaneum] 641673418 XM_008188106.1 209 8.57042e-103 PREDICTED: Acyrthosiphon pisum T-box transcription factor TBX20-like (LOC100167986), partial mRNA K10185 TBX20 T-box protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10185 Q9ES03 958 6.3e-102 T-box transcription factor TBX20 OS=Mus musculus GN=Tbx20 PE=2 SV=3 PF00907 T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3586 TBX1 and related T-box transcription factors Cluster-8309.49522 BF_2 61.18 0.99 2868 642923312 XP_972626.2 1933 1.3e-213 PREDICTED: T-box transcription factor TBX20-like isoform X2 [Tribolium castaneum] 641673418 XM_008188106.1 219 2.35363e-108 PREDICTED: Acyrthosiphon pisum T-box transcription factor TBX20-like (LOC100167986), partial mRNA K10185 TBX20 T-box protein 20 http://www.genome.jp/dbget-bin/www_bget?ko:K10185 Q9ES03 974 8.8e-104 T-box transcription factor TBX20 OS=Mus musculus GN=Tbx20 PE=2 SV=3 PF00907 T-box GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3586 TBX1 and related T-box transcription factors Cluster-8309.49526 BF_2 118.34 1.05 5002 642915929 XP_008190815.1 812 2.3e-83 PREDICTED: putative leucine-rich repeat-containing protein DDB_G0290503 [Tribolium castaneum]>gi|270004085|gb|EFA00533.1| hypothetical protein TcasGA2_TC003398 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 400 5.5e-37 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF03161 LAGLIDADG DNA endonuclease family -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8309.49527 BF_2 39.55 1.62 1309 642914502 XP_008201702.1 1612 1.0e-176 PREDICTED: RUN and FYVE domain-containing protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7L099 792 5.1e-83 Protein RUFY3 OS=Homo sapiens GN=RUFY3 PE=1 SV=1 PF06005 Protein of unknown function (DUF904) GO:0000917//GO:0043093 barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0005737 cytoplasm -- -- Cluster-8309.4953 BF_2 81.63 1.26 2991 642919458 XP_008191877.1 3114 0.0e+00 PREDICTED: gamma-tubulin complex component 2-like [Tribolium castaneum] -- -- -- -- -- K16569 TUBGCP2, GCP2 gamma-tubulin complex component 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16569 Q9BSJ2 1510 6.4e-166 Gamma-tubulin complex component 2 OS=Homo sapiens GN=TUBGCP2 PE=1 SV=2 PF04130 Spc97 / Spc98 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0005815//GO:0000922 microtubule organizing center//spindle pole KOG2001 Gamma-tubulin complex, DGRIP84/SPC97 component Cluster-8309.49531 BF_2 447.71 13.06 1721 578359006 AHI15746.1 1712 3.4e-188 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359005 KJ186848.1 1126 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-1) mRNA, complete cds -- -- -- -- O85465 625 1.5e-63 Endoglucanase 5A OS=Bacillus agaradhaerens GN=cel5A PE=1 SV=1 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.49533 BF_2 175.81 2.38 3380 270008598 EFA05046.1 2573 9.7e-288 hypothetical protein TcasGA2_TC015138 [Tribolium castaneum] 817328593 XM_012435835.1 362 0 PREDICTED: Aotus nancymaae adaptor-related protein complex 3, delta 1 subunit (AP3D1), mRNA K12396 AP3D1 AP-3 complex subunit delta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12396 O54774 1906 8.8e-212 AP-3 complex subunit delta-1 OS=Mus musculus GN=Ap3d1 PE=1 SV=1 PF11698//PF01602//PF02985//PF14532 V-ATPase subunit H//Adaptin N terminal region//HEAT repeat//Sigma-54 interaction domain GO:0006355//GO:0015991//GO:0006886//GO:0016192 regulation of transcription, DNA-templated//ATP hydrolysis coupled proton transport//intracellular protein transport//vesicle-mediated transport GO:0005524//GO:0016820//GO:0008134//GO:0005515 ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//transcription factor binding//protein binding GO:0030117//GO:0005667//GO:0000221 membrane coat//transcription factor complex//vacuolar proton-transporting V-type ATPase, V1 domain KOG1059 Vesicle coat complex AP-3, delta subunit Cluster-8309.49534 BF_2 264.44 3.21 3733 91091446 XP_972658.1 1633 1.1e-178 PREDICTED: kanadaptin [Tribolium castaneum]>gi|270000979|gb|EEZ97426.1| hypothetical protein TcasGA2_TC011256 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BWU0 920 2.1e-97 Kanadaptin OS=Homo sapiens GN=SLC4A1AP PE=1 SV=1 PF03368//PF00498 Dicer dimerisation domain//FHA domain GO:0051252 regulation of RNA metabolic process GO:0005515//GO:0016891 protein binding//endoribonuclease activity, producing 5'-phosphomonoesters -- -- KOG1882 Transcriptional regulator SNIP1, contains FHA domain Cluster-8309.49537 BF_2 187.00 3.54 2494 642912518 XP_008200898.1 3155 0.0e+00 PREDICTED: lysine-specific histone demethylase 1A [Tribolium castaneum] 831537284 XM_012867807.1 99 1.04273e-41 PREDICTED: Fundulus heteroclitus lysine (K)-specific demethylase 1A (kdm1a), transcript variant X2, mRNA K11450 KDM1A, AOF2, LSD1 lysine-specific histone demethylase 1A http://www.genome.jp/dbget-bin/www_bget?ko:K11450 O60341 2321 4.9e-260 Lysine-specific histone demethylase 1A OS=Homo sapiens GN=KDM1A PE=1 SV=2 PF01134//PF02826//PF00070//PF04433//PF01266//PF05834//PF02254//PF01593//PF12831//PF01494//PF07992//PF04799 Glucose inhibited division protein A//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//SWIRM domain//FAD dependent oxidoreductase//Lycopene cyclase protein//TrkA-N domain//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//fzo-like conserved region GO:0006813//GO:0055114//GO:0008033//GO:0008053//GO:0016117 potassium ion transport//oxidation-reduction process//tRNA processing//mitochondrial fusion//carotenoid biosynthetic process GO:0051287//GO:0003924//GO:0005515//GO:0016491//GO:0016705//GO:0071949//GO:0050660 NAD binding//GTPase activity//protein binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//flavin adenine dinucleotide binding GO:0016021//GO:0005741 integral component of membrane//mitochondrial outer membrane KOG0029 Amine oxidase Cluster-8309.49539 BF_2 66.24 0.37 7727 642927000 XP_008195098.1 2561 5.4e-286 PREDICTED: protein disabled isoform X1 [Tribolium castaneum]>gi|270010075|gb|EFA06523.1| hypothetical protein TcasGA2_TC009426 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 681 2.2e-69 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF07415//PF00640//PF08416//PF14719 Gammaherpesvirus latent membrane protein (LMP2) protein//Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine-binding domain//Phosphotyrosine interaction domain (PTB/PID) GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.49540 BF_2 227.08 1.37 7236 642927006 XP_008195101.1 3700 0.0e+00 PREDICTED: protein disabled isoform X4 [Tribolium castaneum] -- -- -- -- -- K12475 DAB2 disabled homolog 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12475 P98081 670 3.9e-68 Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 PF14719//PF00640//PF07415 Phosphotyrosine interaction domain (PTB/PID)//Phosphotyrosine interaction domain (PTB/PID)//Gammaherpesvirus latent membrane protein (LMP2) protein GO:0019042 viral latency GO:0005515 protein binding GO:0033644 host cell membrane KOG3535 Adaptor protein Disabled Cluster-8309.49541 BF_2 42.94 0.47 4112 329350997 AEB91339.1 2095 3.1e-232 salicyl alcohol oxidase paralog 1 [Chrysomela lapponica] -- -- -- -- -- -- -- -- -- P18172 1049 2.5e-112 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF02254//PF05199//PF00732//PF05834//PF07992//PF01534//PF01266 TrkA-N domain//GMC oxidoreductase//GMC oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//Frizzled/Smoothened family membrane region//FAD dependent oxidoreductase GO:0055114//GO:0007166//GO:0016117//GO:0006813 oxidation-reduction process//cell surface receptor signaling pathway//carotenoid biosynthetic process//potassium ion transport GO:0050660//GO:0016491//GO:0016614//GO:0016705 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016020 membrane -- -- Cluster-8309.49542 BF_2 15.74 0.33 2269 642933365 XP_008197385.1 1572 7.7e-172 PREDICTED: uncharacterized protein LOC659874 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49544 BF_2 12.40 0.57 1202 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49546 BF_2 121.92 2.62 2235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49548 BF_2 388.64 1.28 12959 642927168 XP_008195164.1 970 2.8e-101 PREDICTED: protein FAM214A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47180 731 6.0e-75 Polygalacturonase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PGU1 PE=1 SV=1 PF16093//PF00295 Proteasome assembly chaperone 4//Glycosyl hydrolases family 28 GO:0005975//GO:0005985//GO:0043248//GO:0005982 carbohydrate metabolic process//sucrose metabolic process//proteasome assembly//starch metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.49549 BF_2 2339.50 13.67 7445 332376741 AEE63510.1 1257 8.5e-135 unknown [Dendroctonus ponderosae] 665817218 XM_008559146.1 65 2.49654e-22 PREDICTED: Microplitis demolitor glycine N-methyltransferase-like (LOC103578165), mRNA K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q29513 847 1.2e-88 Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1 PF01135//PF05724//PF05175//PF01885//PF08241//PF01909//PF00076//PF09249//PF06220//PF01209 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Thiopurine S-methyltransferase (TPMT)//Methyltransferase small domain//RNA 2'-phosphotransferase, Tpt1 / KptA family//Methyltransferase domain//Nucleotidyltransferase domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//tRNA nucleotidyltransferase, second domain//U1 zinc finger//ubiE/COQ5 methyltransferase family GO:0008152//GO:0006464//GO:0006388//GO:0006479//GO:0046500//GO:0008033 metabolic process//cellular protein modification process//tRNA splicing, via endonucleolytic cleavage and ligation//protein methylation//S-adenosylmethionine metabolic process//tRNA processing GO:0004810//GO:0008757//GO:0016437//GO:0008168//GO:0016772//GO:0008270//GO:0003676//GO:0004719//GO:0016779 tRNA adenylyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//tRNA cytidylyltransferase activity//methyltransferase activity//transferase activity, transferring phosphorus-containing groups//zinc ion binding//nucleic acid binding//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nucleotidyltransferase activity -- -- KOG2278 RNA:NAD 2'-phosphotransferase TPT1 Cluster-8309.49550 BF_2 406.17 9.21 2133 91092074 XP_971115.1 2139 1.3e-237 PREDICTED: uncharacterized protein LOC659745 [Tribolium castaneum]>gi|270004682|gb|EFA01130.1| hypothetical protein TcasGA2_TC010343 [Tribolium castaneum] 642917993 XM_966022.2 289 2.13207e-147 PREDICTED: Tribolium castaneum uncharacterized LOC659745 (LOC659745), mRNA K10480 BTBD8 BTB/POZ domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K10480 Q5XKL5 386 9.9e-36 BTB/POZ domain-containing protein 8 OS=Homo sapiens GN=BTBD8 PE=2 SV=2 PF00651//PF05757 BTB/POZ domain//Oxygen evolving enhancer protein 3 (PsbQ) GO:0015979 photosynthesis GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0009523//GO:0009654//GO:0019898 photosystem II//photosystem II oxygen evolving complex//extrinsic component of membrane KOG1987 Speckle-type POZ protein SPOP and related proteins with TRAF, MATH and BTB/POZ domains Cluster-8309.49553 BF_2 82.86 1.17 3238 642934087 XP_008196609.1 1036 1.6e-109 PREDICTED: phosphatase and actin regulator 1 isoform X4 [Tribolium castaneum] -- -- -- -- -- K17585 PHACTR4 phosphatase and actin regulator 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17585 O75167 481 1.5e-46 Phosphatase and actin regulator 2 OS=Homo sapiens GN=PHACTR2 PE=1 SV=2 PF00344//PF00957 SecY translocase//Synaptobrevin GO:0016192//GO:0015031 vesicle-mediated transport//protein transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4339 RPEL repeat-containing protein Cluster-8309.49556 BF_2 28.90 5.47 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49557 BF_2 35.66 0.35 4519 91085249 XP_973267.1 1086 3.5e-115 PREDICTED: thioredoxin-related transmembrane protein 2 homolog [Tribolium castaneum]>gi|270009096|gb|EFA05544.1| hypothetical protein TcasGA2_TC015732 [Tribolium castaneum] 815899095 XM_012394754.1 156 3.9149e-73 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 3.2e-92 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00085//PF00149//PF02144//PF04139//PF04005 Thioredoxin//Calcineurin-like phosphoesterase//Repair protein Rad1/Rec1/Rad17//Rad9//Hus1-like protein GO:0006281//GO:0045454//GO:0000077 DNA repair//cell redox homeostasis//DNA damage checkpoint GO:0016787 hydrolase activity GO:0030896//GO:0005634 checkpoint clamp complex//nucleus KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.49558 BF_2 49.87 0.48 4619 91085249 XP_973267.1 1086 3.5e-115 PREDICTED: thioredoxin-related transmembrane protein 2 homolog [Tribolium castaneum]>gi|270009096|gb|EFA05544.1| hypothetical protein TcasGA2_TC015732 [Tribolium castaneum] 815899095 XM_012394754.1 156 4.00223e-73 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 3.3e-92 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00085//PF02144//PF00149//PF04139 Thioredoxin//Repair protein Rad1/Rec1/Rad17//Calcineurin-like phosphoesterase//Rad9 GO:0006281//GO:0045454//GO:0000077 DNA repair//cell redox homeostasis//DNA damage checkpoint GO:0016787 hydrolase activity GO:0030896//GO:0005634 checkpoint clamp complex//nucleus KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.49559 BF_2 122.03 6.14 1118 332375811 AEE63046.1 936 2.1e-98 unknown [Dendroctonus ponderosae] 815899095 XM_012394754.1 159 2.03593e-75 PREDICTED: Bombus impatiens vacuolar protein sorting-associated protein 29 (LOC100741775), mRNA K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 876 7.9e-93 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.49560 BF_2 58.26 0.45 5736 642918049 XP_008198995.1 1794 3.5e-197 PREDICTED: ATP-dependent RNA helicase dbp2-like [Tribolium castaneum] 752889233 XM_011264255.1 203 3.71425e-99 PREDICTED: Camponotus floridanus probable ATP-dependent RNA helicase DDX17 (LOC105255133), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q501J6 1428 4.0e-156 Probable ATP-dependent RNA helicase DDX17 OS=Mus musculus GN=Ddx17 PE=1 SV=1 PF00270//PF00004//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Type III restriction enzyme, res subunit -- -- GO:0003677//GO:0016787//GO:0003676//GO:0005524 DNA binding//hydrolase activity//nucleic acid binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.49562 BF_2 347.00 5.85 2767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49566 BF_2 120.81 2.37 2419 642924086 XP_008194000.1 1470 5.5e-160 PREDICTED: mediator of RNA polymerase II transcription subunit 12 isoform X2 [Tribolium castaneum] -- -- -- -- -- K15162 MED12 mediator of RNA polymerase II transcription subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15162 Q9VW47 725 5.5e-75 Mediator of RNA polymerase II transcription subunit 12 OS=Drosophila melanogaster GN=kto PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49568 BF_2 1.63 2.38 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49569 BF_2 250.00 3.85 3006 307196370 EFN77965.1 169 4.9e-09 hypothetical protein EAI_12921, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49572 BF_2 153.46 1.22 5533 642932256 XP_008197035.1 1291 7.2e-139 PREDICTED: uncharacterized protein CG7065 homolog isoform X2 [Tribolium castaneum] 805785462 XM_012284975.1 63 2.39714e-21 PREDICTED: Megachile rotundata uncharacterized protein CG7065-like (LOC100874663), transcript variant X3, mRNA -- -- -- -- Q7YZA2 382 7.5e-35 Uncharacterized protein CG7065 OS=Drosophila melanogaster GN=CG7065 PE=1 SV=1 PF16554 Dimerisation domain of d-ornithine 4,5-aminomutase -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.49574 BF_2 212.01 0.69 13209 642934475 XP_008197679.1 5413 0.0e+00 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X3 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 5.3e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF05510//PF00536//PF00960//PF00023//PF06553//PF13606//PF03400 Sarcoglycan alpha/epsilon//SAM domain (Sterile alpha motif)//Neocarzinostatin family//Ankyrin repeat//BNIP3//Ankyrin repeat//IS1 transposase GO:0043065//GO:0006313//GO:0006952 positive regulation of apoptotic process//transposition, DNA-mediated//defense response GO:0004803//GO:0003677//GO:0005515 transposase activity//DNA binding//protein binding GO:0005740//GO:0016012//GO:0016021 mitochondrial envelope//sarcoglycan complex//integral component of membrane -- -- Cluster-8309.49578 BF_2 50.25 2.25 1222 642933837 XP_008197529.1 190 7.4e-12 PREDICTED: epsin-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49579 BF_2 85.62 1.06 3671 478259957 ENN79759.1 1185 9.3e-127 hypothetical protein YQE_03815, partial [Dendroctonus ponderosae]>gi|546681505|gb|ERL91582.1| hypothetical protein D910_08912 [Dendroctonus ponderosae] -- -- -- -- -- K05614 SLC1A3, EAAT1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05614 P24942 748 1.8e-77 Excitatory amino acid transporter 1 OS=Rattus norvegicus GN=Slc1a3 PE=1 SV=2 PF02535//PF01903//PF00375 ZIP Zinc transporter//CbiX//Sodium:dicarboxylate symporter family GO:0030001//GO:0055085//GO:0006783//GO:0009236//GO:0006820//GO:0006835//GO:0006812 metal ion transport//transmembrane transport//heme biosynthetic process//cobalamin biosynthetic process//anion transport//dicarboxylic acid transport//cation transport GO:0017153//GO:0016852//GO:0046873 sodium:dicarboxylate symporter activity//sirohydrochlorin cobaltochelatase activity//metal ion transmembrane transporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.49582 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49583 BF_2 282.13 2.82 4472 91081955 XP_967420.1 2620 4.5e-293 PREDICTED: cullin-3 [Tribolium castaneum]>gi|270007361|gb|EFA03809.1| hypothetical protein TcasGA2_TC013922 [Tribolium castaneum] 755982854 XM_011311736.1 332 5.62708e-171 PREDICTED: Fopius arisanus cullin-3 (LOC105270650), mRNA K03869 CUL3 cullin 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03869 B5DF89 2168 4.8e-242 Cullin-3 OS=Rattus norvegicus GN=Cul3 PE=1 SV=2 PF02023//PF00888//PF12422 SCAN domain//Cullin family//Condensin II non structural maintenance of chromosomes subunit GO:0006511//GO:0006355 ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated GO:0003700//GO:0031625 transcription factor activity, sequence-specific DNA binding//ubiquitin protein ligase binding GO:0005667//GO:0005634//GO:0031461 transcription factor complex//nucleus//cullin-RING ubiquitin ligase complex KOG2166 Cullins Cluster-8309.49588 BF_2 45.00 74.92 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49590 BF_2 91.49 0.59 6728 642912146 XP_008200825.1 1113 3.8e-118 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNM6 504 6.5e-49 Protein FAM102A OS=Xenopus laevis GN=fam102a PE=2 SV=1 PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.49591 BF_2 286.39 2.32 5456 642912146 XP_008200825.1 635 8.3e-63 PREDICTED: uncharacterized protein LOC656488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07660 Secretin and TonB N terminus short domain -- -- -- -- GO:0019867 outer membrane -- -- Cluster-8309.49593 BF_2 301.61 5.25 2691 332374548 AEE62415.1 509 1.7e-48 unknown [Dendroctonus ponderosae]>gi|478260072|gb|ENN79857.1| hypothetical protein YQE_03677, partial [Dendroctonus ponderosae]>gi|546676791|gb|ERL87737.1| hypothetical protein D910_05126 [Dendroctonus ponderosae] -- -- -- -- -- K03671 trxA thioredoxin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03671 Q95108 302 6.9e-26 Thioredoxin, mitochondrial OS=Bos taurus GN=TXN2 PE=1 SV=2 PF02966//PF01323//PF00085//PF08534//PF00462//PF07689 Mitosis protein DIM1//DSBA-like thioredoxin domain//Thioredoxin//Redoxin//Glutaredoxin//KaiB domain GO:0048511//GO:0000398//GO:0045454//GO:0006118 rhythmic process//mRNA splicing, via spliceosome//cell redox homeostasis//obsolete electron transport GO:0016491//GO:0015035//GO:0009055 oxidoreductase activity//protein disulfide oxidoreductase activity//electron carrier activity GO:0005681 spliceosomal complex KOG0910 Thioredoxin-like protein Cluster-8309.49595 BF_2 846.73 7.51 5003 642919677 XP_968051.2 1092 7.7e-116 PREDICTED: uncharacterized protein LOC656425 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VBW5 307 3.4e-26 HMG box transcription factor BBX OS=Mus musculus GN=Bbx PE=1 SV=2 PF13014//PF08785//PF00013//PF11520 KH domain//Ku C terminal domain like//KH domain//Chromatin protein Cren7 -- -- GO:0003690//GO:0016817//GO:0003723 double-stranded DNA binding//hydrolase activity, acting on acid anhydrides//RNA binding GO:0005737 cytoplasm KOG2746 HMG-box transcription factor Capicua and related proteins Cluster-8309.49596 BF_2 19.65 1.23 954 546677206 ERL88085.1 163 7.8e-09 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49597 BF_2 37.61 0.62 2812 546677626 ERL88431.1 2497 5.2e-279 hypothetical protein D910_05817, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VUY0 1367 2.3e-149 MOXD1 homolog 1 OS=Drosophila melanogaster GN=CG5235 PE=2 SV=2 PF01082//PF07465 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//Photosystem I protein M (PsaM) GO:0055114//GO:0015979 oxidation-reduction process//photosynthesis GO:0004497//GO:0016715//GO:0005507 monooxygenase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//copper ion binding -- -- KOG3568 Dopamine beta-monooxygenase Cluster-8309.49598 BF_2 65.82 1.08 2829 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49599 BF_2 88.10 0.59 6511 478257181 ENN77344.1 2459 3.1e-274 hypothetical protein YQE_06170, partial [Dendroctonus ponderosae]>gi|546681413|gb|ERL91510.1| hypothetical protein D910_08840 [Dendroctonus ponderosae] 471419251 XM_004391060.1 39 6.19627e-08 PREDICTED: Trichechus manatus latirostris F-box and WD repeat domain containing 5 (LOC101355169), mRNA K10263 FBXW5 F-box and WD-40 domain protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10263 Q9QXW2 1187 4.0e-128 F-box/WD repeat-containing protein 5 OS=Mus musculus GN=Fbxw5 PE=1 SV=1 PF01105//PF00646//PF00400//PF00355//PF12937 emp24/gp25L/p24 family/GOLD//F-box domain//WD domain, G-beta repeat//Rieske [2Fe-2S] domain//F-box-like GO:0006810//GO:0055114 transport//oxidation-reduction process GO:0051537//GO:0016491//GO:0005515 2 iron, 2 sulfur cluster binding//oxidoreductase activity//protein binding GO:0016021 integral component of membrane KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.49604 BF_2 72.00 1.01 3270 642937391 XP_008198818.1 551 2.7e-53 PREDICTED: carboxypeptidase N subunit 2-like [Tribolium castaneum]>gi|270001112|gb|EEZ97559.1| hypothetical protein TcasGA2_TC011413 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02833 197 1.3e-13 Insulin-like growth factor-binding protein complex acid labile subunit OS=Papio hamadryas GN=IGFALS PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.49605 BF_2 7.85 19.77 276 546677909 ERL88653.1 190 1.6e-12 hypothetical protein D910_06037 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49606 BF_2 196.19 0.73 11468 642929737 XP_008195956.1 3594 0.0e+00 PREDICTED: zinc finger SWIM domain-containing protein 6-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P217 2085 5.2e-232 Zinc finger SWIM domain-containing protein 5 OS=Homo sapiens GN=ZSWIM5 PE=2 SV=2 PF02724//PF02892//PF04851//PF02861//PF00570//PF00270//PF01189//PF05063//PF09382 CDC45-like protein//BED zinc finger//Type III restriction enzyme, res subunit//Clp amino terminal domain, pathogenicity island component//HRDC domain//DEAD/DEAH box helicase//16S rRNA methyltransferase RsmF//MT-A70//RQC domain GO:0006260//GO:0019538//GO:0006281//GO:0006270//GO:0006139 DNA replication//protein metabolic process//DNA repair//DNA replication initiation//nucleobase-containing compound metabolic process GO:0008168//GO:0003676//GO:0043140//GO:0005524//GO:0003677//GO:0016787 methyltransferase activity//nucleic acid binding//ATP-dependent 3'-5' DNA helicase activity//ATP binding//DNA binding//hydrolase activity GO:0005622//GO:0005657 intracellular//replication fork KOG0351 ATP-dependent DNA helicase Cluster-8309.49607 BF_2 633.00 24.03 1389 91085415 XP_967672.1 937 2.0e-98 PREDICTED: ell-associated factor Eaf [Tribolium castaneum]>gi|642926746|ref|XP_008194996.1| PREDICTED: ell-associated factor Eaf [Tribolium castaneum]>gi|270009158|gb|EFA05606.1| hypothetical protein TcasGA2_TC015812 [Tribolium castaneum] 642926744 XM_962579.2 42 2.78714e-10 PREDICTED: Tribolium castaneum ell-associated factor Eaf (LOC656023), transcript variant X1, mRNA K15186 EAF ELL-associated factor http://www.genome.jp/dbget-bin/www_bget?ko:K15186 B4P1N5 480 8.1e-47 Ell-associated factor Eaf OS=Drosophila yakuba GN=Eaf PE=3 SV=1 PF07943 Penicillin-binding protein 5, C-terminal domain GO:0006508 proteolysis GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity -- -- KOG4795 Protein associated with transcriptional elongation factor ELL Cluster-8309.49609 BF_2 201.10 1.54 5751 642938278 XP_008192712.1 3280 0.0e+00 PREDICTED: serine/threonine-protein kinase tousled-like 2 isoform X2 [Tribolium castaneum] 642938291 XM_008194530.1 978 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase tousled-like 2 (LOC655717), transcript variant X9, mRNA K08864 TLK tousled-like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08864 O55047 1829 1.3e-202 Serine/threonine-protein kinase tousled-like 2 OS=Mus musculus GN=Tlk2 PE=1 SV=2 PF07714//PF00069//PF12142 Protein tyrosine kinase//Protein kinase domain//Polyphenol oxidase middle domain GO:0006118//GO:0055114//GO:0006468//GO:0006570 obsolete electron transport//oxidation-reduction process//protein phosphorylation//tyrosine metabolic process GO:0005524//GO:0004097//GO:0004672 ATP binding//catechol oxidase activity//protein kinase activity -- -- KOG1151 Tousled-like protein kinase Cluster-8309.49610 BF_2 249.24 3.79 3040 642930253 XP_008196317.1 1147 2.0e-122 PREDICTED: lachesin-like [Tribolium castaneum]>gi|642930255|ref|XP_008196318.1| PREDICTED: lachesin-like [Tribolium castaneum]>gi|642930257|ref|XP_008196319.1| PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49613 BF_2 110.77 1.29 3876 642914292 XP_008201625.1 1104 2.4e-117 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 O14733 934 5.1e-99 Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens GN=MAP2K7 PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0983 Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2 Cluster-8309.49616 BF_2 182.79 6.76 1419 642914292 XP_008201625.1 1443 4.4e-157 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 O14733 1119 6.7e-121 Dual specificity mitogen-activated protein kinase kinase 7 OS=Homo sapiens GN=MAP2K7 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0983 Mitogen-activated protein kinase (MAPK) kinase MKK7/JNKK2 Cluster-8309.49617 BF_2 300.79 6.47 2231 642914292 XP_008201625.1 587 1.2e-57 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 Q23977 182 4.7e-12 Dual specificity mitogen-activated protein kinase kinase hemipterous OS=Drosophila melanogaster GN=hep PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49619 BF_2 12.00 3.19 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49620 BF_2 5.28 0.72 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49621 BF_2 162.72 5.69 1483 270008954 EFA05402.1 1409 4.0e-153 hypothetical protein TcasGA2_TC015574 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49622 BF_2 6.00 0.56 732 478250699 ENN71191.1 204 1.1e-13 hypothetical protein YQE_12120, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49623 BF_2 57.19 0.38 6565 270010424 EFA06872.1 8503 0.0e+00 hypothetical protein TcasGA2_TC009817 [Tribolium castaneum] 642928920 XM_008197395.1 1349 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 34 (LOC659997), mRNA K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q70CQ2 4681 0.0e+00 Ubiquitin carboxyl-terminal hydrolase 34 OS=Homo sapiens GN=USP34 PE=1 SV=2 PF01080//PF02985//PF00443//PF05395 Presenilin//HEAT repeat//Ubiquitin carboxyl-terminal hydrolase//Protein phosphatase inhibitor 1/DARPP-32 GO:0007165//GO:0016579 signal transduction//protein deubiquitination GO:0036459//GO:0004864//GO:0004190//GO:0005515 ubiquitinyl hydrolase activity//protein phosphatase inhibitor activity//aspartic-type endopeptidase activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.49626 BF_2 648.34 5.96 4834 91076220 XP_972698.1 3287 0.0e+00 PREDICTED: solute carrier organic anion transporter family member 5A1 [Tribolium castaneum]>gi|270014737|gb|EFA11185.1| hypothetical protein TcasGA2_TC004793 [Tribolium castaneum] 462373375 APGK01024771.1 206 6.71995e-101 Dendroctonus ponderosae Seq01024781, whole genome shotgun sequence K14353 SLCO3A solute carrier organic anion transporter family, member 3A http://www.genome.jp/dbget-bin/www_bget?ko:K14353 Q9H2Y9 912 2.3e-96 Solute carrier organic anion transporter family member 5A1 OS=Homo sapiens GN=SLCO5A1 PE=2 SV=2 PF07690//PF03137//PF00050//PF07648 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0055085//GO:0006810 transmembrane transport//transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.49627 BF_2 181.93 2.74 3066 282165752 NP_001164117.1 1291 4.0e-139 uncharacterized protein LOC100322888 [Tribolium castaneum]>gi|270013327|gb|EFA09775.1| hypothetical protein TcasGA2_TC011917 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49630 BF_2 444.99 24.18 1057 -- -- -- -- -- 642916845 XM_008201305.1 130 2.53876e-59 PREDICTED: Tribolium castaneum failed axon connections (LOC656797), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49633 BF_2 32.87 0.90 1811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-8309.49634 BF_2 61.11 2.85 1184 156546413 XP_001607107.1 442 4.3e-41 PREDICTED: pyridoxal kinase isoform X2 [Nasonia vitripennis] -- -- -- -- -- K00868 pdxK, pdxY pyridoxine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00868 Q8W1X2 370 3.9e-34 Pyridoxal kinase OS=Arabidopsis thaliana GN=PK PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2599 Pyridoxal/pyridoxine/pyridoxamine kinase Cluster-8309.49637 BF_2 190.43 2.38 3638 91076374 XP_967954.1 2668 1.0e-298 PREDICTED: DNA ligase 3 [Tribolium castaneum]>gi|270002897|gb|EEZ99344.1| ligase III [Tribolium castaneum] -- -- -- -- -- K10776 LIG3 DNA ligase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10776 P49916 2093 2.0e-233 DNA ligase 3 OS=Homo sapiens GN=LIG3 PE=1 SV=2 PF04675//PF04679//PF02229//PF01068//PF00645 DNA ligase N terminus//ATP dependent DNA ligase C terminal region//Transcriptional Coactivator p15 (PC4)//ATP dependent DNA ligase domain//Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region GO:0006281//GO:0006260//GO:0006355//GO:0006310 DNA repair//DNA replication//regulation of transcription, DNA-templated//DNA recombination GO:0003677//GO:0005524//GO:0003713//GO:0003909//GO:0000166//GO:0008270//GO:0043167//GO:0003910 DNA binding//ATP binding//transcription coactivator activity//DNA ligase activity//nucleotide binding//zinc ion binding//ion binding//DNA ligase (ATP) activity GO:0005667 transcription factor complex KOG0967 ATP-dependent DNA ligase I Cluster-8309.49639 BF_2 11.40 0.59 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49640 BF_2 38.69 0.72 2525 91080515 XP_971732.1 844 2.2e-87 PREDICTED: galectin-8-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O00214 373 3.8e-34 Galectin-8 OS=Homo sapiens GN=LGALS8 PE=1 SV=4 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- KOG3587 Galectin, galactose-binding lectin Cluster-8309.49643 BF_2 6.00 0.46 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49644 BF_2 296.00 4.06 3336 270007486 EFA03934.1 2860 0.0e+00 hypothetical protein TcasGA2_TC014074 [Tribolium castaneum] -- -- -- -- -- K18643 KATNB1 katanin p80 WD40 repeat-containing subunit B1 http://www.genome.jp/dbget-bin/www_bget?ko:K18643 O61585 1038 3.9e-111 Katanin p80 WD40 repeat-containing subunit B1 OS=Strongylocentrotus purpuratus GN=KATNB1 PE=1 SV=1 PF13931//PF00400 Kinesin-associated microtubule-binding//WD domain, G-beta repeat -- -- GO:0008017//GO:0005515 microtubule binding//protein binding GO:0045298 tubulin complex KOG0267 Microtubule severing protein katanin p80 subunit B (contains WD40 repeats) Cluster-8309.49648 BF_2 55.68 2.12 1388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02790 Cytochrome C oxidase subunit II, transmembrane domain GO:0022900 electron transport chain -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49649 BF_2 21.81 0.52 2026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49652 BF_2 112.16 1.80 2896 642921163 XP_008192741.1 2292 3.2e-255 PREDICTED: sip1/TFIP11 interacting protein isoform X1 [Tribolium castaneum]>gi|270006305|gb|EFA02753.1| hypothetical protein TcasGA2_TC008486 [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q0IIX9 1226 5.3e-133 Tuftelin-interacting protein 11 OS=Xenopus tropicalis GN=tfip11 PE=2 SV=2 PF07842//PF01585 GC-rich sequence DNA-binding factor-like protein//G-patch domain GO:0008380//GO:0006355//GO:0006397 RNA splicing//regulation of transcription, DNA-templated//mRNA processing GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0005681//GO:0005634 spliceosomal complex//nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.49655 BF_2 16.30 0.80 1143 478252346 ENN72772.1 192 4.0e-12 hypothetical protein YQE_10577, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O00462 143 8.0e-08 Beta-mannosidase OS=Homo sapiens GN=MANBA PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49656 BF_2 248.06 3.69 3102 642939784 XP_970158.2 1230 4.8e-132 PREDICTED: mesoderm induction early response protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T105 566 1.9e-56 Mesoderm induction early response protein 1 OS=Xenopus laevis GN=mier1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2133 Transcriptional corepressor Atrophin-1/DRPLA Cluster-8309.49657 BF_2 22.22 0.38 2755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00647//PF03609 Elongation factor 1 gamma, conserved domain//PTS system sorbose-specific iic component GO:0009401//GO:0006414//GO:0006448 phosphoenolpyruvate-dependent sugar phosphotransferase system//translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0016021//GO:0005840 integral component of membrane//ribosome -- -- Cluster-8309.49658 BF_2 483.67 4.30 4991 390362249 XP_001190749.2 1582 1.2e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 2.8e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00906//PF00023//PF00866//PF01637//PF13606 Hepatitis core antigen//Ankyrin repeat//Ring hydroxylating beta subunit//Archaeal ATPase//Ankyrin repeat GO:0055114//GO:0006725//GO:0009405 oxidation-reduction process//cellular aromatic compound metabolic process//pathogenesis GO:0005198//GO:0005515//GO:0005524//GO:0003824 structural molecule activity//protein binding//ATP binding//catalytic activity -- -- -- -- Cluster-8309.49660 BF_2 21.94 0.75 1515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49663 BF_2 191.62 1.45 5819 270009582 EFA06030.1 3434 0.0e+00 hypothetical protein TcasGA2_TC008860 [Tribolium castaneum] 749781041 XM_011146561.1 110 1.88176e-47 PREDICTED: Harpegnathos saltator uncharacterized LOC105186395 (LOC105186395), mRNA K05725 PTK2, FAK focal adhesion kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05725 Q05397 1800 3.0e-199 Focal adhesion kinase 1 OS=Homo sapiens GN=PTK2 PE=1 SV=2 PF00069//PF03623//PF07714 Protein kinase domain//Focal adhesion targeting region//Protein tyrosine kinase GO:0006468//GO:0007172//GO:0007165 protein phosphorylation//signal complex assembly//signal transduction GO:0004713//GO:0005524//GO:0004672//GO:0004871 protein tyrosine kinase activity//ATP binding//protein kinase activity//signal transducer activity GO:0005925 focal adhesion KOG4257 Focal adhesion tyrosine kinase FAK, contains FERM domain Cluster-8309.49665 BF_2 106.37 1.46 3342 270010224 EFA06672.1 3668 0.0e+00 hypothetical protein TcasGA2_TC009600 [Tribolium castaneum] -- -- -- -- -- K02324 POLE1 DNA polymerase epsilon subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02324 Q9WVF7 2204 2.4e-246 DNA polymerase epsilon catalytic subunit A OS=Mus musculus GN=Pole PE=2 SV=3 PF05280//PF08490 Flagellar transcriptional activator (FlhC)//Domain of unknown function (DUF1744) GO:0045893//GO:1902208//GO:0006260 positive regulation of transcription, DNA-templated//regulation of bacterial-type flagellum assembly//DNA replication GO:0003677//GO:0003887//GO:0008270 DNA binding//DNA-directed DNA polymerase activity//zinc ion binding GO:0005634//GO:0042575 nucleus//DNA polymerase complex KOG1798 DNA polymerase epsilon, catalytic subunit A Cluster-8309.49669 BF_2 25.49 0.82 1590 642924008 XP_008193967.1 180 1.4e-10 PREDICTED: ran-binding protein 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07557 Shugoshin C terminus GO:0045132 meiotic chromosome segregation -- -- GO:0005634//GO:0000775 nucleus//chromosome, centromeric region -- -- Cluster-8309.49672 BF_2 259.95 4.85 2528 270014679 EFA11127.1 658 8.2e-66 hypothetical protein TcasGA2_TC004728 [Tribolium castaneum] -- -- -- -- -- K09273 UBTF upstream-binding transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09273 P25980 300 1.1e-25 Nucleolar transcription factor 1-B OS=Xenopus laevis GN=ubtf-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49673 BF_2 53.28 0.94 2667 478254798 ENN75034.1 1439 2.4e-156 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 167 1.76485e-79 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 980 1.6e-104 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF03526 Colicin E1 (microcin) immunity protein GO:0006955//GO:0030153 immune response//bacteriocin immunity GO:0015643 toxic substance binding GO:0019814 immunoglobulin complex KOG3530 FERM domain protein EHM2 Cluster-8309.49677 BF_2 424.11 4.04 4677 728417025 AIY68331.1 3720 0.0e+00 putative gliotactin [Leptinotarsa decemlineata] 645019941 XM_008208782.1 61 2.61802e-20 PREDICTED: Nasonia vitripennis gliotactin (LOC100120557), transcript variant X3, mRNA -- -- -- -- Q69ZK9 628 1.9e-63 Neuroligin-2 OS=Mus musculus GN=Nlgn2 PE=1 SV=2 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.49680 BF_2 70.00 4.21 982 270013391 EFA09839.1 1541 1.3e-168 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UM47 220 8.1e-17 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.49684 BF_2 14.00 0.67 1157 674304018 AIL23540.1 317 1.3e-26 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 250 3.2e-20 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 PF13409//PF13417//PF02798 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49685 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49686 BF_2 28.00 0.74 1880 478267740 ENN83098.1 409 4.6e-37 hypothetical protein YQE_00541, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B0BN95 185 1.8e-12 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49688 BF_2 389.41 2.12 7971 189236343 XP_975398.2 2270 3.1e-252 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X3 [Tribolium castaneum] 642919611 XM_008193717.1 100 9.34839e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.7e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF01388//PF12031//PF02257 ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518)//RFX DNA-binding domain GO:0006355//GO:0006338 regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.49689 BF_2 3.20 0.43 598 91086889 XP_970389.1 228 1.4e-16 PREDICTED: lipoma HMGIC fusion partner-like 2 protein [Tribolium castaneum]>gi|642929193|ref|XP_008195730.1| PREDICTED: lipoma HMGIC fusion partner-like 2 protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49691 BF_2 130.53 1.64 3622 642917011 XP_008199595.1 1252 1.6e-134 PREDICTED: probable ATP-dependent RNA helicase DHX35 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O77475 954 2.3e-101 Ceramide phosphoethanolamine synthase OS=Drosophila melanogaster GN=CG4585 PE=1 SV=1 PF01066//PF04548//PF00503//PF00437//PF03193//PF00005 CDP-alcohol phosphatidyltransferase//AIG1 family//G-protein alpha subunit//Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter GO:0006810//GO:0007165//GO:0008654//GO:0007186 transport//signal transduction//phospholipid biosynthetic process//G-protein coupled receptor signaling pathway GO:0003924//GO:0016780//GO:0005524//GO:0031683//GO:0005525//GO:0004871//GO:0019001//GO:0016887 GTPase activity//phosphotransferase activity, for other substituted phosphate groups//ATP binding//G-protein beta/gamma-subunit complex binding//GTP binding//signal transducer activity//guanyl nucleotide binding//ATPase activity GO:0016020 membrane KOG0922 DEAH-box RNA helicase Cluster-8309.49692 BF_2 21.74 0.34 2925 91086413 XP_967009.1 1442 1.2e-156 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270010301|gb|EFA06749.1| hypothetical protein TcasGA2_TC009683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4MYA4 555 3.4e-55 Facilitated trehalose transporter Tret1 OS=Drosophila willistoni GN=Tret1 PE=3 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.49693 BF_2 23.11 0.33 3257 642917000 XP_008199589.1 225 1.7e-15 PREDICTED: uncharacterized protein LOC100142249 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00317 Ribonucleotide reductase, all-alpha domain GO:0006260//GO:0006206//GO:0055114//GO:0009186//GO:0006144 DNA replication//pyrimidine nucleobase metabolic process//oxidation-reduction process//deoxyribonucleoside diphosphate metabolic process//purine nucleobase metabolic process GO:0005524//GO:0004748 ATP binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-8309.49697 BF_2 216.93 1.33 7087 91078242 XP_970298.1 3529 0.0e+00 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 642939064 XM_008201985.1 402 0 PREDICTED: Tribolium castaneum xenotropic and polytropic retrovirus receptor 1 (LOC100142189), transcript variant X2, mRNA -- -- -- -- Q9UBH6 1815 6.6e-201 Xenotropic and polytropic retrovirus receptor 1 OS=Homo sapiens GN=XPR1 PE=1 SV=1 PF01504//PF03124 Phosphatidylinositol-4-phosphate 5-Kinase//EXS family GO:0046488 phosphatidylinositol metabolic process GO:0016307//GO:0043167 phosphatidylinositol phosphate kinase activity//ion binding GO:0016021 integral component of membrane KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.49698 BF_2 166.81 3.57 2244 91078242 XP_970298.1 2598 8.1e-291 PREDICTED: 1-phosphatidylinositol 3-phosphate 5-kinase [Tribolium castaneum]>gi|270003932|gb|EFA00380.1| hypothetical protein TcasGA2_TC003226 [Tribolium castaneum] 462322709 APGK01042728.1 101 7.24129e-43 Dendroctonus ponderosae Seq01042738, whole genome shotgun sequence K00921 PIKFYVE, FAB1 1-phosphatidylinositol-3-phosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00921 Q9Z1T6 1105 4.4e-119 1-phosphatidylinositol 3-phosphate 5-kinase OS=Mus musculus GN=Pikfyve PE=1 SV=3 PF00118//PF00610//PF00851//PF01363 TCP-1/cpn60 chaperonin family//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP)//Helper component proteinase//FYVE zinc finger GO:0006508//GO:0035556//GO:0046854//GO:0044267 proteolysis//intracellular signal transduction//phosphatidylinositol phosphorylation//cellular protein metabolic process GO:0016307//GO:0004197//GO:0046872//GO:0005524 phosphatidylinositol phosphate kinase activity//cysteine-type endopeptidase activity//metal ion binding//ATP binding GO:0005622 intracellular KOG0230 Phosphatidylinositol-4-phosphate 5-kinase and related FYVE finger-containing proteins Cluster-8309.49699 BF_2 36.81 0.53 3196 189235866 XP_969616.2 3011 0.0e+00 PREDICTED: pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 [Tribolium castaneum]>gi|270004535|gb|EFA00983.1| hypothetical protein TcasGA2_TC003896 [Tribolium castaneum] 242012722 XM_002427032.1 375 0 Pediculus humanus corporis splicing factor ATP-dependent RNA helicase prp16, putative, mRNA K12815 DHX38, PRP16 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX38/PRP16 http://www.genome.jp/dbget-bin/www_bget?ko:K12815 Q17R09 2191 7.4e-245 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 OS=Bos taurus GN=DHX38 PE=2 SV=1 PF02562//PF01637//PF00005//PF00931//PF00270//PF07652//PF02407//PF00158//PF00448//PF00437 PhoH-like protein//Archaeal ATPase//ABC transporter//NB-ARC domain//DEAD/DEAH box helicase//Flavivirus DEAD domain//Putative viral replication protein//Sigma-54 interaction domain//SRP54-type protein, GTPase domain//Type II/IV secretion system protein GO:0006144//GO:0006308//GO:0019079//GO:0006614//GO:0006810//GO:0018142//GO:0006260//GO:0006355 purine nucleobase metabolic process//DNA catabolic process//viral genome replication//SRP-dependent cotranslational protein targeting to membrane//transport//protein-DNA covalent cross-linking//DNA replication//regulation of transcription, DNA-templated GO:0004386//GO:0016888//GO:0043531//GO:0008026//GO:0003676//GO:0042624//GO:0005525//GO:0005524//GO:0008134//GO:0016887//GO:0000166//GO:0016779 helicase activity//endodeoxyribonuclease activity, producing 5'-phosphomonoesters//ADP binding//ATP-dependent helicase activity//nucleic acid binding//ATPase activity, uncoupled//GTP binding//ATP binding//transcription factor binding//ATPase activity//nucleotide binding//nucleotidyltransferase activity GO:0005667 transcription factor complex KOG0924 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.49700 BF_2 111.98 1.49 3434 642927046 XP_008195117.1 2581 1.2e-288 PREDICTED: putative ATP-dependent RNA helicase DHX30 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13185 DHX30 ATP-dependent RNA helicase DHX30 http://www.genome.jp/dbget-bin/www_bget?ko:K13185 Q5ZI74 1067 1.7e-114 Putative ATP-dependent RNA helicase DHX30 OS=Gallus gallus GN=DHX30 PE=2 SV=1 PF03193//PF04408//PF00270 Protein of unknown function, DUF258//Helicase associated domain (HA2)//DEAD/DEAH box helicase -- -- GO:0003924//GO:0003676//GO:0004386//GO:0005524//GO:0005525 GTPase activity//nucleic acid binding//helicase activity//ATP binding//GTP binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.49701 BF_2 106.12 1.72 2873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49702 BF_2 51.29 1.50 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49703 BF_2 21.62 0.78 1440 478250432 ENN70927.1 363 7.6e-32 hypothetical protein YQE_12329, partial [Dendroctonus ponderosae]>gi|546677342|gb|ERL88199.1| hypothetical protein D910_05588 [Dendroctonus ponderosae] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 290 9.1e-25 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3573 Caspase, apoptotic cysteine protease Cluster-8309.49704 BF_2 27.52 0.73 1873 642921248 XP_969543.2 768 1.1e-78 PREDICTED: PERQ amino acid-rich with GYF domain-containing protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K18730 GIGYF PERQ amino acid-rich with GYF domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18730 Q7KQM6 245 2.0e-19 PERQ amino acid-rich with GYF domain-containing protein CG11148 OS=Drosophila melanogaster GN=CG11148 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49710 BF_2 19.31 2.06 679 91088697 XP_975033.1 140 2.6e-06 PREDICTED: uncharacterized protein LOC663911 [Tribolium castaneum]>gi|270011669|gb|EFA08117.1| hypothetical protein TcasGA2_TC005721 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.49712 BF_2 32.22 1.00 1640 123482337 XP_001323756.1 242 9.2e-18 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- Q9EP71 189 5.3e-13 Ankycorbin OS=Mus musculus GN=Rai14 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.49717 BF_2 285.89 4.21 3130 91094507 XP_971663.1 1499 3.1e-163 PREDICTED: 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial [Tribolium castaneum]>gi|270000751|gb|EEZ97198.1| hypothetical protein TcasGA2_TC004386 [Tribolium castaneum] -- -- -- -- -- K00166 BCKDHA, bkdA1 2-oxoisovalerate dehydrogenase E1 component alpha subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00166 Q8HXY4 1341 2.7e-146 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial OS=Macaca fascicularis GN=BCKDHA PE=2 SV=1 PF00676//PF02775//PF13292 Dehydrogenase E1 component//Thiamine pyrophosphate enzyme, C-terminal TPP binding domain//1-deoxy-D-xylulose-5-phosphate synthase GO:0016114//GO:0006694//GO:0008152 terpenoid biosynthetic process//steroid biosynthetic process//metabolic process GO:0030976//GO:0008661//GO:0016624//GO:0003824 thiamine pyrophosphate binding//1-deoxy-D-xylulose-5-phosphate synthase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor//catalytic activity -- -- KOG0225 Pyruvate dehydrogenase E1, alpha subunit Cluster-8309.49719 BF_2 76.01 1.08 3221 270014279 EFA10727.1 1613 1.9e-176 cappuccino [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 781 2.4e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.49720 BF_2 1300.00 65.30 1120 332372686 AEE61485.1 1029 3.5e-109 unknown [Dendroctonus ponderosae]>gi|478255312|gb|ENN75538.1| hypothetical protein YQE_07881, partial [Dendroctonus ponderosae]>gi|546683134|gb|ERL92985.1| hypothetical protein D910_10288 [Dendroctonus ponderosae] 268557825 XM_002636857.1 54 4.77246e-17 Caenorhabditis briggsae C. briggsae CBR-PAS-6 protein (Cbr-pas-6) mRNA, partial cds K02725 PSMA1 20S proteasome subunit alpha 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02725 Q9R1P4 832 1.0e-87 Proteasome subunit alpha type-1 OS=Mus musculus GN=Psma1 PE=1 SV=1 PF00227//PF10584 Proteasome subunit//Proteasome subunit A N-terminal signature GO:0006511//GO:0051603 ubiquitin-dependent protein catabolic process//proteolysis involved in cellular protein catabolic process GO:0004175//GO:0004298 endopeptidase activity//threonine-type endopeptidase activity GO:0005839//GO:0019773 proteasome core complex//proteasome core complex, alpha-subunit complex KOG0863 20S proteasome, regulatory subunit alpha type PSMA1/PRE5 Cluster-8309.49724 BF_2 322.48 3.60 4038 642938312 XP_008192824.1 857 1.1e-88 PREDICTED: cyclic AMP-responsive element-binding protein 1 isoform X6 [Tribolium castaneum] 642938311 XM_008194602.1 163 4.48901e-77 PREDICTED: Tribolium castaneum cyclic AMP-responsive element-binding protein 1 (LOC656052), transcript variant X7, mRNA K09050 CREBN cAMP response element-binding protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09050 Q9VWW0 285 9.7e-24 Cyclic AMP response element-binding protein B OS=Drosophila melanogaster GN=CrebB PE=1 SV=1 PF03131//PF00170//PF07716//PF02173 bZIP Maf transcription factor//bZIP transcription factor//Basic region leucine zipper//pKID domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0003677//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.49726 BF_2 61.15 1.02 2801 91078176 XP_967241.1 2271 8.4e-253 PREDICTED: peroxidase [Tribolium castaneum]>gi|642915052|ref|XP_008190390.1| PREDICTED: peroxidase [Tribolium castaneum]>gi|270002725|gb|EEZ99172.1| hypothetical protein TcasGA2_TC000175 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q01603 1711 3.0e-189 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- GO:0006979//GO:0006804//GO:0055114 response to oxidative stress//obsolete peroxidase reaction//oxidation-reduction process GO:0004601//GO:0020037 peroxidase activity//heme binding -- -- -- -- Cluster-8309.49727 BF_2 3.00 14.41 254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04577 Protein of unknown function (DUF563) -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- -- -- Cluster-8309.49732 BF_2 657.95 9.19 3282 91090264 XP_970269.1 888 2.3e-92 PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934841|ref|XP_008197832.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934843|ref|XP_008197833.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|642934845|ref|XP_008197834.1| PREDICTED: E3 ubiquitin-protein ligase RNF185 [Tribolium castaneum]>gi|270013784|gb|EFA10232.1| hypothetical protein TcasGA2_TC012429 [Tribolium castaneum] 780638303 XM_011689036.1 101 1.06373e-42 PREDICTED: Wasmannia auropunctata E3 ubiquitin-protein ligase RNF185-like (LOC105449687), transcript variant X4, mRNA K10666 RNF5 E3 ubiquitin-protein ligase RNF5 http://www.genome.jp/dbget-bin/www_bget?ko:K10666 Q5ZIR9 677 2.8e-69 E3 ubiquitin-protein ligase RNF185 OS=Gallus gallus GN=RNF185 PE=2 SV=1 PF13639//PF17123//PF12678//PF12861//PF14634//PF00219//PF00097 Ring finger domain//RING-like zinc finger//RING-H2 zinc finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//Insulin-like growth factor binding protein//Zinc finger, C3HC4 type (RING finger) GO:0016567//GO:0001558 protein ubiquitination//regulation of cell growth GO:0005520//GO:0005515//GO:0004842//GO:0008270//GO:0046872 insulin-like growth factor binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding//metal ion binding GO:0016942//GO:0005680//GO:0005576 insulin-like growth factor binding protein complex//anaphase-promoting complex//extracellular region KOG0823 Predicted E3 ubiquitin ligase Cluster-8309.49734 BF_2 4.16 0.41 709 546684826 ERL94408.1 431 4.9e-40 hypothetical protein D910_11687, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q42524 237 6.2e-19 4-coumarate--CoA ligase 1 OS=Arabidopsis thaliana GN=4CL1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.49736 BF_2 25.00 0.39 2967 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49737 BF_2 24.06 3.08 614 270008217 EFA04665.1 256 8.2e-20 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 219 6.6e-17 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.49741 BF_2 30.56 0.49 2886 478260286 ENN80038.1 1121 1.9e-119 hypothetical protein YQE_03515, partial [Dendroctonus ponderosae] -- -- -- -- -- K03660 OGG1 N-glycosylase/DNA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K03660 O70249 689 9.8e-71 N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1 PF13895//PF07934//PF00730//PF00633 Immunoglobulin domain//8-oxoguanine DNA glycosylase, N-terminal domain//HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006289//GO:0006308//GO:0006285//GO:0006281//GO:0006284 nucleotide-excision repair//DNA catabolic process//base-excision repair, AP site formation//DNA repair//base-excision repair GO:0003684//GO:0008534//GO:0005515//GO:0003677 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//protein binding//DNA binding -- -- KOG2875 8-oxoguanine DNA glycosylase Cluster-8309.49742 BF_2 26.60 0.60 2135 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49746 BF_2 44.00 10.05 470 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49747 BF_2 10.55 0.87 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49749 BF_2 2.00 3.18 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49752 BF_2 13.55 0.31 2105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49754 BF_2 35.29 0.62 2662 642919697 XP_008192026.1 1931 2.1e-213 PREDICTED: putative ATP-dependent RNA helicase DHX57 [Tribolium castaneum]>gi|270005433|gb|EFA01881.1| hypothetical protein TcasGA2_TC007486 [Tribolium castaneum] -- -- -- -- -- K13026 DHX57 ATP-dependent RNA helicase DHX57 http://www.genome.jp/dbget-bin/www_bget?ko:K13026 Q6P158 776 7.4e-81 Putative ATP-dependent RNA helicase DHX57 OS=Homo sapiens GN=DHX57 PE=1 SV=2 PF01609//PF00270//PF00437//PF05773//PF00642//PF00005 Transposase DDE domain//DEAD/DEAH box helicase//Type II/IV secretion system protein//RWD domain//Zinc finger C-x8-C-x5-C-x3-H type (and similar)//ABC transporter GO:0006313//GO:0006810 transposition, DNA-mediated//transport GO:0005524//GO:0003677//GO:0008026//GO:0005515//GO:0008270//GO:0003676//GO:0016887//GO:0004803//GO:0046872 ATP binding//DNA binding//ATP-dependent helicase activity//protein binding//zinc ion binding//nucleic acid binding//ATPase activity//transposase activity//metal ion binding -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.49755 BF_2 118.64 1.86 2962 642935358 XP_008197980.1 1345 2.1e-145 PREDICTED: uncharacterized protein LOC657906 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E9QJ05 145 1.2e-07 Protein PET117 homolog, mitochondrial OS=Danio rerio GN=pet117 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49758 BF_2 127.00 8.50 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49760 BF_2 14.00 2.36 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49761 BF_2 262.40 4.23 2881 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49763 BF_2 26.60 0.64 2027 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49765 BF_2 75.00 1.57 2288 91089021 XP_968771.1 1518 1.4e-165 PREDICTED: peptidyl-prolyl cis-trans isomerase-like 4 [Tribolium castaneum]>gi|270011537|gb|EFA07985.1| hypothetical protein TcasGA2_TC005570 [Tribolium castaneum] 665815434 XM_008558152.1 39 2.1577e-08 PREDICTED: Microplitis demolitor peptidyl-prolyl cis-trans isomerase-like 4 (LOC103577497), mRNA K12735 PPIL4 peptidyl-prolyl cis-trans isomerase-like 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12735 Q8WUA2 1130 5.7e-122 Peptidyl-prolyl cis-trans isomerase-like 4 OS=Homo sapiens GN=PPIL4 PE=1 SV=1 PF00160//PF00076 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0000413//GO:0044267//GO:0006457 protein peptidyl-prolyl isomerization//cellular protein metabolic process//protein folding GO:1901363//GO:0003676//GO:0097159//GO:0003755//GO:0016853 heterocyclic compound binding//nucleic acid binding//organic cyclic compound binding//peptidyl-prolyl cis-trans isomerase activity//isomerase activity -- -- KOG0415 Predicted peptidyl prolyl cis-trans isomerase Cluster-8309.49766 BF_2 61.11 1.09 2622 531447909 AGT57849.1 927 5.5e-97 cytochrome P450 6bq15, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 601 1.4e-60 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00328//PF04083//PF00067 Histidine phosphatase superfamily (branch 2)//Partial alpha/beta-hydrolase lipase region//Cytochrome P450 GO:0006771//GO:0055114//GO:0019497//GO:0006629 riboflavin metabolic process//oxidation-reduction process//hexachlorocyclohexane metabolic process//lipid metabolic process GO:0003993//GO:0020037//GO:0005506//GO:0016705 acid phosphatase activity//heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.4977 BF_2 1.00 1.52 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49770 BF_2 14.90 0.37 1978 642919664 XP_008192013.1 539 4.1e-52 PREDICTED: gamma-sarcoglycan [Tribolium castaneum]>gi|270005447|gb|EFA01895.1| hypothetical protein TcasGA2_TC007505 [Tribolium castaneum] -- -- -- -- -- K12563 SGCD delta-sarcoglycan http://www.genome.jp/dbget-bin/www_bget?ko:K12563 Q92629 269 3.4e-22 Delta-sarcoglycan OS=Homo sapiens GN=SGCD PE=1 SV=2 PF04790 Sarcoglycan complex subunit protein GO:0007010 cytoskeleton organization -- -- GO:0016012//GO:0016021 sarcoglycan complex//integral component of membrane KOG3950 Gamma/delta sarcoglycan Cluster-8309.49772 BF_2 321.75 4.69 3155 642927886 XP_001813556.2 1242 2.0e-133 PREDICTED: follistatin [Tribolium castaneum] -- -- -- -- -- K04661 FST follistatin http://www.genome.jp/dbget-bin/www_bget?ko:K04661 P31514 642 3.0e-65 Follistatin (Fragment) OS=Ovis aries GN=FST PE=2 SV=1 PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.49774 BF_2 19.38 1.53 818 91078712 XP_966534.1 541 9.8e-53 PREDICTED: ethanolamine-phosphate cytidylyltransferase [Tribolium castaneum]>gi|270003752|gb|EFA00200.1| hypothetical protein TcasGA2_TC003025 [Tribolium castaneum] -- -- -- -- -- K00967 PCYT2 ethanolamine-phosphate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00967 Q5EA75 432 1.8e-41 Ethanolamine-phosphate cytidylyltransferase OS=Bos taurus GN=PCYT2 PE=2 SV=1 PF01467 Cytidylyltransferase-like GO:0009058 biosynthetic process GO:0003824//GO:0016779 catalytic activity//nucleotidyltransferase activity -- -- KOG2804 Phosphorylcholine transferase/cholinephosphate cytidylyltransferase Cluster-8309.49777 BF_2 633.51 2.30 11802 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 800 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.1e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF06743//PF01017//PF03124//PF01436//PF14634//PF00643//PF00097 FAST kinase-like protein, subdomain 1//STAT protein, all-alpha domain//EXS family//NHL repeat//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0004871//GO:0003700//GO:0046872//GO:0004672 protein binding//zinc ion binding//signal transducer activity//transcription factor activity, sequence-specific DNA binding//metal ion binding//protein kinase activity GO:0016021//GO:0005667//GO:0005622 integral component of membrane//transcription factor complex//intracellular KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.49778 BF_2 253.96 3.64 3204 642927083 XP_008195130.1 3664 0.0e+00 PREDICTED: leucine-rich repeat and WD repeat-containing protein KIAA1239 isoform X1 [Tribolium castaneum]>gi|270010029|gb|EFA06477.1| hypothetical protein TcasGA2_TC009369 [Tribolium castaneum] 642927082 XM_008196908.1 494 0 PREDICTED: Tribolium castaneum leucine-rich repeat and WD repeat-containing protein KIAA1239 (LOC660120), transcript variant X1, mRNA -- -- -- -- Q9ULI1 406 7.1e-38 NACHT and WD repeat domain-containing protein 2 OS=Homo sapiens GN=NWD2 PE=2 SV=3 PF00004//PF07728//PF00931//PF00910//PF03193//PF00005//PF00006//PF04851//PF01637 ATPase family associated with various cellular activities (AAA)//AAA domain (dynein-related subfamily)//NB-ARC domain//RNA helicase//Protein of unknown function, DUF258//ABC transporter//ATP synthase alpha/beta family, nucleotide-binding domain//Type III restriction enzyme, res subunit//Archaeal ATPase -- -- GO:0003924//GO:0043531//GO:0016787//GO:0003677//GO:0005524//GO:0003723//GO:0003724//GO:0016887//GO:0005525 GTPase activity//ADP binding//hydrolase activity//DNA binding//ATP binding//RNA binding//RNA helicase activity//ATPase activity//GTP binding -- -- -- -- Cluster-8309.49780 BF_2 3.00 0.54 518 751454280 XP_011181606.1 196 6.3e-13 PREDICTED: uncharacterized protein LOC105211716 [Bactrocera cucurbitae] -- -- -- -- -- K00505 TYR tyrosinase http://www.genome.jp/dbget-bin/www_bget?ko:K00505 Q8I1F6 183 8.3e-13 Phenoloxidase 3 OS=Drosophila erecta GN=PPO3 PE=3 SV=2 PF00264 Common central domain of tyrosinase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.49783 BF_2 24.70 0.49 2392 91084077 XP_968062.1 632 8.1e-63 PREDICTED: protein odr-4 homolog [Tribolium castaneum]>gi|270008008|gb|EFA04456.1| hypothetical protein TcasGA2_TC014760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWX8 234 4.7e-18 Protein odr-4 homolog OS=Homo sapiens GN=ODR4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49784 BF_2 10.00 0.62 958 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49786 BF_2 260.75 2.66 4395 189239183 XP_966847.2 1778 1.9e-195 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q69ZF3 1014 3.1e-108 Non-lysosomal glucosylceramidase OS=Mus musculus GN=Gba2 PE=1 SV=2 PF01232//PF04685 Mannitol dehydrogenase Rossmann domain//Protein of unknown function, DUF608 GO:0006687//GO:0005975//GO:0006807//GO:0055114//GO:0006665 glycosphingolipid metabolic process//carbohydrate metabolic process//nitrogen compound metabolic process//oxidation-reduction process//sphingolipid metabolic process GO:0004348//GO:0016798//GO:0016491 glucosylceramidase activity//hydrolase activity, acting on glycosyl bonds//oxidoreductase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.49787 BF_2 948.56 12.83 3380 189239183 XP_966847.2 2940 0.0e+00 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q5M868 1550 1.7e-170 Non-lysosomal glucosylceramidase OS=Rattus norvegicus GN=Gba2 PE=2 SV=2 PF04685 Protein of unknown function, DUF608 GO:0006665//GO:0006680//GO:0006807//GO:0006687//GO:0005975 sphingolipid metabolic process//glucosylceramide catabolic process//nitrogen compound metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process GO:0004348 glucosylceramidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.49788 BF_2 240.05 3.77 2950 642930159 XP_008196277.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 5.7e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00989//PF00072//PF05504//PF00233//PF09771 PAS fold//Response regulator receiver domain//Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188 GO:0009847//GO:0006355//GO:0006144//GO:0007165//GO:0035307//GO:0000160 spore germination//regulation of transcription, DNA-templated//purine nucleobase metabolic process//signal transduction//positive regulation of protein dephosphorylation//phosphorelay signal transduction system GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.49789 BF_2 151.85 1.96 3530 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 6.9e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00072//PF00989//PF00233//PF05504//PF09771 Response regulator receiver domain//PAS fold//3'5'-cyclic nucleotide phosphodiesterase//Spore germination B3/ GerAC like, C-terminal//Transmembrane protein 188 GO:0006355//GO:0009847//GO:0006144//GO:0035307//GO:0000160//GO:0007165 regulation of transcription, DNA-templated//spore germination//purine nucleobase metabolic process//positive regulation of protein dephosphorylation//phosphorelay signal transduction system//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.49790 BF_2 61.25 1.91 1632 642911138 XP_971944.3 561 9.4e-55 PREDICTED: mitochondrial folate transporter/carrier isoform X2 [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q95J75 320 3.4e-28 Mitochondrial folate transporter/carrier OS=Macaca fascicularis GN=SLC25A32 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0764 Mitochondrial FAD carrier protein Cluster-8309.49793 BF_2 237.06 2.78 3854 478251380 ENN71846.1 1036 1.9e-109 hypothetical protein YQE_11464, partial [Dendroctonus ponderosae] -- -- -- -- -- K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 Q7ZXE9 429 1.9e-40 Testin OS=Xenopus laevis GN=tes PE=2 SV=1 PF06297//PF00412 PET Domain//LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.49794 BF_2 107.61 1.77 2829 91079124 XP_975420.1 615 8.9e-61 PREDICTED: proteasome assembly chaperone 2 [Tribolium castaneum]>gi|270003633|gb|EFA00081.1| hypothetical protein TcasGA2_TC002896 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14735//PF13912//PF07776//PF13465//PF00096//PF07975 HAUS augmin-like complex subunit 4//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain GO:0006281//GO:0051225 DNA repair//spindle assembly GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0070652//GO:0005634 HAUS complex//nucleus -- -- Cluster-8309.49797 BF_2 54.19 0.32 7306 642911815 XP_008200755.1 6671 0.0e+00 PREDICTED: protein SZT2-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 611 2.8e-61 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 PF01726 LexA DNA binding domain GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.49803 BF_2 33.65 1.98 999 642915450 XP_008190622.1 1185 2.5e-127 PREDICTED: E3 ubiquitin-protein ligase MYCBP2 [Tribolium castaneum] -- -- -- -- -- K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 Q7TPH6 828 2.6e-87 E3 ubiquitin-protein ligase MYCBP2 OS=Mus musculus GN=Mycbp2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49807 BF_2 358.57 2.47 6363 270003917 EFA00365.1 7046 0.0e+00 hypothetical protein TcasGA2_TC003207 [Tribolium castaneum] 820837995 XM_012494632.1 48 6.01194e-13 PREDICTED: Apis florea E3 ubiquitin-protein ligase highwire-like (LOC100865814), transcript variant X9, mRNA K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 3448 0.0e+00 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF13639//PF17123 Ring finger domain//RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49808 BF_2 78.43 0.52 6655 270003917 EFA00365.1 6460 0.0e+00 hypothetical protein TcasGA2_TC003207 [Tribolium castaneum] 820837995 XM_012494632.1 48 6.28944e-13 PREDICTED: Apis florea E3 ubiquitin-protein ligase highwire-like (LOC100865814), transcript variant X9, mRNA K10693 MYCBP2, PAM E3 ubiquitin-protein ligase MYCBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K10693 O75592 3448 0.0e+00 E3 ubiquitin-protein ligase MYCBP2 OS=Homo sapiens GN=MYCBP2 PE=1 SV=3 PF17123//PF13639 RING-like zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515 zinc ion binding//protein binding -- -- KOG1428 Inhibitor of type V adenylyl cyclases/Neuronal presynaptic protein Highwire/PAM/RPM-1 Cluster-8309.49813 BF_2 60.79 0.73 3794 270008949 EFA05397.1 1203 7.9e-129 hypothetical protein TcasGA2_TC015569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P97279 629 1.2e-63 Inter-alpha-trypsin inhibitor heavy chain H2 OS=Mesocricetus auratus GN=ITIH2 PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.49815 BF_2 2.00 5.17 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49816 BF_2 28.60 1.16 1315 478252870 ENN73259.1 802 8.6e-83 hypothetical protein YQE_10155, partial [Dendroctonus ponderosae]>gi|546674747|gb|ERL86052.1| hypothetical protein D910_03466 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U145 311 3.0e-27 Transmembrane protein 64 OS=Mus musculus GN=Tmem64 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49817 BF_2 46.54 0.70 3077 751425405 AJF93908.1 2411 5.4e-269 FTZ F1 alpha [Leptinotarsa decemlineata] 642917896 XM_008193152.1 798 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X2, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1606 4.9e-177 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00288//PF00104//PF00105 GHMP kinases N terminal domain//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0003700//GO:0043565//GO:0008270 ATP binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.49818 BF_2 39.72 0.69 2691 751425407 AJF93909.1 2380 1.8e-265 FTZ F1 beta [Leptinotarsa decemlineata] 642917898 XM_008193153.1 541 0 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1628 1.2e-179 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00288//PF00104//PF00105 GHMP kinases N terminal domain//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0005524//GO:0043565//GO:0008270//GO:0003700 ATP binding//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.49819 BF_2 92.77 2.27 1994 751425407 AJF93909.1 2183 9.5e-243 FTZ F1 beta [Leptinotarsa decemlineata] 751425406 KM091936.1 662 0 Leptinotarsa decemlineata FTZ F1 beta mRNA, complete cds K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 1453 1.7e-159 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4218 Nuclear hormone receptor betaFTZ-F1 Cluster-8309.49822 BF_2 17.71 0.49 1807 642913378 XP_008195461.1 728 4.5e-74 PREDICTED: uncharacterized protein LOC657396 isoform X2 [Tribolium castaneum]>gi|270002028|gb|EEZ98475.1| hypothetical protein TcasGA2_TC000967 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.49823 BF_2 193.24 3.42 2653 189240781 XP_969579.2 1520 9.6e-166 PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum]>gi|642934322|ref|XP_008198600.1| PREDICTED: inositol hexakisphosphate kinase 1 isoform X2 [Tribolium castaneum] 831504568 XM_012856442.1 55 3.19778e-17 PREDICTED: Fundulus heteroclitus inositol hexakisphosphate kinase 1 (ip6k1), mRNA K07756 IP6K, IHPK inositol-hexakisphosphate 5-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K07756 Q96PC2 434 3.4e-41 Inositol hexakisphosphate kinase 3 OS=Homo sapiens GN=IP6K3 PE=1 SV=2 PF03770 Inositol polyphosphate kinase -- -- GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity -- -- KOG1620 Inositol polyphosphate multikinase, component of the ARGR transcription regulatory complex Cluster-8309.49825 BF_2 84.24 2.31 1811 345488645 XP_003425958.1 1012 5.3e-107 PREDICTED: T-cell activation inhibitor, mitochondrial isoform X1 [Nasonia vitripennis]>gi|645006689|ref|XP_008204888.1| PREDICTED: T-cell activation inhibitor, mitochondrial isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q66JZ4 365 2.3e-33 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.49826 BF_2 73.27 1.84 1953 546674929 ERL86206.1 678 3.1e-68 hypothetical protein D910_03617 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49828 BF_2 27.96 2.09 848 642937828 XP_008200318.1 532 1.1e-51 PREDICTED: ethanolamine kinase 2 [Tribolium castaneum] -- -- -- -- -- K00894 ETNK, EKI ethanolamine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00894 Q9NVF9 395 3.6e-37 Ethanolamine kinase 2 OS=Homo sapiens GN=ETNK2 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4720 Ethanolamine kinase Cluster-8309.4983 BF_2 1.00 0.34 408 166998659 NP_001107798.1 252 1.6e-19 Snipper [Tribolium castaneum]>gi|156447793|gb|ABU63675.1| Snipper [Tribolium castaneum] -- -- -- -- -- K18417 ERI2 ERI1 exoribonuclease 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18417 A8K979 200 7.0e-15 ERI1 exoribonuclease 2 OS=Homo sapiens GN=ERI2 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0542 Predicted exonuclease Cluster-8309.49830 BF_2 18.65 0.50 1861 91094379 XP_970941.1 1077 1.6e-114 PREDICTED: 39S ribosomal protein L4, mitochondrial [Tribolium castaneum]>gi|270014913|gb|EFA11361.1| hypothetical protein TcasGA2_TC011518 [Tribolium castaneum] -- -- -- -- -- K02926 RP-L4, MRPL4, rplD large subunit ribosomal protein L4 http://www.genome.jp/dbget-bin/www_bget?ko:K02926 Q32PI6 676 2.0e-69 39S ribosomal protein L4, mitochondrial OS=Bos taurus GN=MRPL4 PE=1 SV=1 PF01084//PF03497//PF00573 Ribosomal protein S18//Anthrax toxin LF subunit//Ribosomal protein L4/L1 family GO:0042254//GO:0006171//GO:0006412//GO:0009405 ribosome biogenesis//cAMP biosynthetic process//translation//pathogenesis GO:0003735//GO:0008294 structural constituent of ribosome//calcium- and calmodulin-responsive adenylate cyclase activity GO:0005576//GO:0005840//GO:0005622 extracellular region//ribosome//intracellular KOG1624 Mitochondrial/chloroplast ribosomal protein L4 Cluster-8309.49831 BF_2 134.54 1.62 3765 189240011 XP_970535.2 1502 1.7e-163 PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Tribolium castaneum]>gi|642931571|ref|XP_008196639.1| PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Tribolium castaneum]>gi|270012173|gb|EFA08621.1| hypothetical protein TcasGA2_TC006284 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P20735 957 1.1e-101 Gamma-glutamyltranspeptidase 1 OS=Sus scrofa GN=GGT1 PE=2 SV=1 PF01019 Gamma-glutamyltranspeptidase GO:0006749//GO:0006693//GO:0019530//GO:0006691 glutathione metabolic process//prostaglandin metabolic process//taurine metabolic process//leukotriene metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.49833 BF_2 1138.26 20.79 2578 478256352 ENN76542.1 1586 2.1e-173 hypothetical protein YQE_06993, partial [Dendroctonus ponderosae] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 Q60928 969 3.0e-103 Gamma-glutamyltranspeptidase 1 OS=Mus musculus GN=Ggt1 PE=1 SV=1 PF01019 Gamma-glutamyltranspeptidase GO:0019530//GO:0006691//GO:0006693//GO:0006749 taurine metabolic process//leukotriene metabolic process//prostaglandin metabolic process//glutathione metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.49834 BF_2 121.02 1.36 4003 189240011 XP_970535.2 1502 1.8e-163 PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Tribolium castaneum]>gi|642931571|ref|XP_008196639.1| PREDICTED: gamma-glutamyltranspeptidase 1 isoform X2 [Tribolium castaneum]>gi|270012173|gb|EFA08621.1| hypothetical protein TcasGA2_TC006284 [Tribolium castaneum] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P20735 957 1.1e-101 Gamma-glutamyltranspeptidase 1 OS=Sus scrofa GN=GGT1 PE=2 SV=1 PF01019 Gamma-glutamyltranspeptidase GO:0006749//GO:0006693//GO:0019530//GO:0006691 glutathione metabolic process//prostaglandin metabolic process//taurine metabolic process//leukotriene metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.49837 BF_2 1013.28 5.53 7953 86515334 NP_001034492.1 4335 0.0e+00 chitin synthase 2 [Tribolium castaneum]>gi|33867321|gb|AAQ55061.1| chitin synthase CHS2 [Tribolium castaneum]>gi|34148365|gb|AAQ62692.1| chitin synthase [Tribolium castaneum]>gi|270014271|gb|EFA10719.1| chitin synthase 2 [Tribolium castaneum] -- -- -- -- -- K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q9H3F6 928 5.2e-98 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 OS=Homo sapiens GN=KCTD10 PE=1 SV=1 PF03233//PF02214//PF02186//PF00651 Aphid transmission protein//BTB/POZ domain//TFIIE beta subunit core domain//BTB/POZ domain GO:0051260//GO:0006367//GO:0019089 protein homooligomerization//transcription initiation from RNA polymerase II promoter//transmission of virus GO:0016757//GO:0005515 transferase activity, transferring glycosyl groups//protein binding -- -- KOG2716 Polymerase delta-interacting protein PDIP1 and related proteins, contain BTB/POZ domain Cluster-8309.49839 BF_2 105.45 1.01 4654 91077854 XP_972003.1 1652 8.3e-181 PREDICTED: tetratricopeptide repeat protein 7B [Tribolium castaneum]>gi|270002262|gb|EEZ98709.1| hypothetical protein TcasGA2_TC001250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86TV6 645 2.0e-65 Tetratricopeptide repeat protein 7B OS=Homo sapiens GN=TTC7B PE=1 SV=3 PF00515//PF13374//PF13181//PF13371//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG4162 Predicted calmodulin-binding protein Cluster-8309.49842 BF_2 0.98 0.47 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49846 BF_2 18.00 2.00 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49847 BF_2 200.92 2.19 4126 642931643 XP_008196669.1 765 5.3e-78 PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum]>gi|642931645|ref|XP_972490.2| PREDICTED: suppressor of cytokine signaling 2 [Tribolium castaneum] -- -- -- -- -- K04701 CISH cytokine inducible SH2-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K04701 O14508 228 4.0e-17 Suppressor of cytokine signaling 2 OS=Homo sapiens GN=SOCS2 PE=1 SV=1 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.49848 BF_2 231.06 1.47 6852 194880788 XP_001974544.1 2122 3.9e-235 GG21804 [Drosophila erecta]>gi|190657731|gb|EDV54944.1| GG21804 [Drosophila erecta] 572319027 XM_006625008.1 56 2.313e-17 PREDICTED: Apis dorsata E3 ubiquitin-protein ligase SMURF1-like (LOC102679083), mRNA K04678 SMURF E3 ubiquitin ligase SMURF1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K04678 A9JRZ0 1867 5.9e-207 E3 ubiquitin-protein ligase SMURF2 OS=Danio rerio GN=smurf2 PE=2 SV=1 PF00397//PF00632 WW domain//HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0005515//GO:0004842 protein binding//ubiquitin-protein transferase activity GO:0005622 intracellular KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.49852 BF_2 20.18 0.39 2452 308495432 XP_003109904.1 230 3.4e-16 hypothetical protein CRE_06611 [Caenorhabditis remanei]>gi|308244741|gb|EFO88693.1| hypothetical protein CRE_06611 [Caenorhabditis remanei] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49854 BF_2 392.66 10.79 1810 478259707 ENN79551.1 501 9.5e-48 hypothetical protein YQE_04013, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49859 BF_2 3.00 0.38 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49862 BF_2 25.32 0.95 1405 478257589 ENN77743.1 1232 1.3e-132 hypothetical protein YQE_05813, partial [Dendroctonus ponderosae]>gi|546677142|gb|ERL88039.1| hypothetical protein D910_05428 [Dendroctonus ponderosae] -- -- -- -- -- K00049 GRHPR glyoxylate/hydroxypyruvate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00049 Q9UBQ7 790 9.3e-83 Glyoxylate reductase/hydroxypyruvate reductase OS=Homo sapiens GN=GRHPR PE=1 SV=1 PF03435//PF02325//PF13241//PF01408//PF00389//PF00899//PF02826//PF03446//PF00044//PF01118//PF02254 Saccharopine dehydrogenase NADP binding domain//YGGT family//Putative NAD(P)-binding//Oxidoreductase family, NAD-binding Rossmann fold//D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain//ThiF family//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//Semialdehyde dehydrogenase, NAD binding domain//TrkA-N domain GO:0055114//GO:0006779//GO:0019521//GO:0006813//GO:0008152//GO:0019354//GO:0006098 oxidation-reduction process//porphyrin-containing compound biosynthetic process//D-gluconate metabolic process//potassium ion transport//metabolic process//siroheme biosynthetic process//pentose-phosphate shunt GO:0016620//GO:0008641//GO:0004616//GO:0051287//GO:0016616//GO:0016491//GO:0043115 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//small protein activating enzyme activity//phosphogluconate dehydrogenase (decarboxylating) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//precorrin-2 dehydrogenase activity GO:0016020 membrane KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.49865 BF_2 218.93 3.31 3050 642922596 XP_970120.2 1845 2.3e-203 PREDICTED: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Tribolium castaneum] -- -- -- -- -- K05543 DUS2 tRNA-dihydrouridine synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05543 Q9NX74 1063 4.5e-114 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Homo sapiens GN=DUS2 PE=1 SV=1 PF10541//PF00977//PF01207 Nuclear envelope localisation domain//Histidine biosynthesis protein//Dihydrouridine synthase (Dus) GO:0055114//GO:0000105//GO:0008033 oxidation-reduction process//histidine biosynthetic process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity GO:0016021 integral component of membrane KOG2334 tRNA-dihydrouridine synthase Cluster-8309.49870 BF_2 28.77 0.70 2010 307197059 EFN78431.1 161 2.8e-08 Transposable element Tc3 transposase, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49872 BF_2 62.48 0.66 4248 546685737 ERL95192.1 1349 1.0e-145 hypothetical protein D910_12460 [Dendroctonus ponderosae] -- -- -- -- -- K14286 AGXT2L1, ETNPPL ethanolamine-phosphate phospho-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K14286 Q9VU95 1056 4.0e-113 Alanine--glyoxylate aminotransferase 2-like OS=Drosophila melanogaster GN=CG8745 PE=2 SV=2 PF03431//PF00202 RNA replicase, beta-chain//Aminotransferase class-III GO:0006144//GO:0019079 purine nucleobase metabolic process//viral genome replication GO:0008483//GO:0030170//GO:0003968 transaminase activity//pyridoxal phosphate binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex KOG1404 Alanine-glyoxylate aminotransferase AGT2 Cluster-8309.49873 BF_2 199.56 1.62 5433 546681355 ERL91465.1 2903 0.0e+00 hypothetical protein D910_08795 [Dendroctonus ponderosae] -- -- -- -- -- K13983 MOV10L1 putative helicase MOV10L1 http://www.genome.jp/dbget-bin/www_bget?ko:K13983 Q6J5K9 1597 9.5e-176 Probable RNA helicase armi OS=Drosophila melanogaster GN=armi PE=1 SV=4 PF00789//PF07545//PF04851//PF01443//PF02562 UBX domain//Vestigial/Tondu family//Type III restriction enzyme, res subunit//Viral (Superfamily 1) RNA helicase//PhoH-like protein GO:0006355 regulation of transcription, DNA-templated GO:0005524//GO:0016787//GO:0003677//GO:0005515 ATP binding//hydrolase activity//DNA binding//protein binding GO:0005634 nucleus KOG1802 RNA helicase nonsense mRNA reducing factor (pNORF1) Cluster-8309.49877 BF_2 309.03 10.20 1554 91081503 XP_974574.1 1439 1.4e-156 PREDICTED: actin-related protein 10 [Tribolium castaneum]>gi|270006151|gb|EFA02599.1| hypothetical protein TcasGA2_TC008318 [Tribolium castaneum] -- -- -- -- -- K16576 ACTR10, ARP11 actin-related protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K16576 Q9QZB7 822 2.0e-86 Actin-related protein 10 OS=Mus musculus GN=Actr10 PE=1 SV=2 PF09446 VMA21-like domain GO:0070072 vacuolar proton-transporting V-type ATPase complex assembly -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.49880 BF_2 76.84 1.91 1973 642910469 XP_008200226.1 1008 1.7e-106 PREDICTED: uncharacterized protein LOC659133 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 242 4.6e-19 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.49881 BF_2 13.00 0.91 886 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49882 BF_2 119.41 1.23 4338 478261444 ENN80814.1 1613 2.6e-176 hypothetical protein YQE_02771, partial [Dendroctonus ponderosae]>gi|546676398|gb|ERL87418.1| hypothetical protein D910_04813 [Dendroctonus ponderosae] 462382197 APGK01021748.1 104 3.03015e-44 Dendroctonus ponderosae Seq01021758, whole genome shotgun sequence K02433 gatA, QRSL1 aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02433 Q17H91 1361 1.8e-148 Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial OS=Aedes aegypti GN=gatA PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1211 Amidases Cluster-8309.49884 BF_2 169.98 4.17 1992 332376669 AEE63474.1 618 2.8e-61 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B5XB27 336 5.8e-30 Kynurenine formamidase OS=Salmo salar GN=afmid PE=2 SV=1 PF00183//PF00326//PF07859 Hsp90 protein//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006950//GO:0008152//GO:0006457//GO:0006508 response to stress//metabolic process//protein folding//proteolysis GO:0005524//GO:0016787//GO:0051082//GO:0008236 ATP binding//hydrolase activity//unfolded protein binding//serine-type peptidase activity -- -- -- -- Cluster-8309.49885 BF_2 1658.39 30.22 2583 332376669 AEE63474.1 695 4.3e-70 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B5XB27 393 1.9e-36 Kynurenine formamidase OS=Salmo salar GN=afmid PE=2 SV=1 PF00183//PF00326//PF07859 Hsp90 protein//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0006950//GO:0008152//GO:0006457 proteolysis//response to stress//metabolic process//protein folding GO:0008236//GO:0051082//GO:0005524//GO:0016787 serine-type peptidase activity//unfolded protein binding//ATP binding//hydrolase activity -- -- -- -- Cluster-8309.49886 BF_2 341.00 22.83 912 642917470 XP_008191215.1 274 1.0e-21 PREDICTED: uncharacterized protein LOC103312421 [Tribolium castaneum]>gi|642917472|ref|XP_008191216.1| PREDICTED: uncharacterized protein LOC103312421 [Tribolium castaneum]>gi|270003451|gb|EEZ99898.1| hypothetical protein TcasGA2_TC002682 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49890 BF_2 4.01 0.86 482 270015258 EFA11706.1 244 1.6e-18 hypothetical protein TcasGA2_TC001793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49892 BF_2 379.78 6.34 2793 270010128 EFA06576.1 1043 2.1e-110 hypothetical protein TcasGA2_TC009488 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Q968 711 2.7e-73 Protein N-terminal glutamine amidohydrolase OS=Anopheles gambiae GN=tun PE=3 SV=3 PF09764 N-terminal glutamine amidase GO:0006807 nitrogen compound metabolic process GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides -- -- KOG3261 Uncharacterized conserved protein Cluster-8309.49893 BF_2 166.47 3.81 2114 642929595 XP_008195898.1 1519 1.0e-165 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 992 5.3e-106 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF04721 PNGase C-terminal domain, mannose-binding module PAW GO:0006516 glycoprotein catabolic process -- -- GO:0005737 cytoplasm KOG0909 Peptide:N-glycanase Cluster-8309.49894 BF_2 188.76 1.55 5374 642929595 XP_008195898.1 1497 9.0e-163 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 986 6.7e-105 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF02532//PF04721//PF06736//PF08395 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//PNGase C-terminal domain, mannose-binding module PAW//Protein of unknown function (DUF1211)//7tm Chemosensory receptor GO:0050909//GO:0006516//GO:0006813//GO:0015979 sensory perception of taste//glycoprotein catabolic process//potassium ion transport//photosynthesis GO:0005267 potassium channel activity GO:0009539//GO:0009523//GO:0005737//GO:0016020//GO:0016021 photosystem II reaction center//photosystem II//cytoplasm//membrane//integral component of membrane KOG0909 Peptide:N-glycanase Cluster-8309.49898 BF_2 64.64 0.48 5910 642929595 XP_008195898.1 1192 2.3e-127 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q9JI78 876 4.2e-92 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Mus musculus GN=Ngly1 PE=1 SV=2 PF02532//PF04721//PF06736//PF10843//PF08395 Photosystem II reaction centre I protein (PSII 4.8 kDa protein)//PNGase C-terminal domain, mannose-binding module PAW//Protein of unknown function (DUF1211)//Protein of unknown function (DUF2578)//7tm Chemosensory receptor GO:0006112//GO:0006813//GO:0015979//GO:0050909//GO:0006516 energy reserve metabolic process//potassium ion transport//photosynthesis//sensory perception of taste//glycoprotein catabolic process GO:0005267 potassium channel activity GO:0016021//GO:0009539//GO:0005737//GO:0009523//GO:0016020 integral component of membrane//photosystem II reaction center//cytoplasm//photosystem II//membrane KOG0909 Peptide:N-glycanase Cluster-8309.49899 BF_2 1823.37 20.09 4084 820805532 AKG92757.1 3460 0.0e+00 helix loop helix protein 106 [Leptinotarsa decemlineata] -- -- -- -- -- K07197 SREBP1, SREBF1 sterol regulatory element-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07197 Q60416 1235 6.8e-134 Sterol regulatory element-binding protein 1 OS=Cricetulus griseus GN=SREBF1 PE=2 SV=1 PF01166//PF15898//PF00010 TSC-22/dip/bun family//cGMP-dependent protein kinase interacting domain//Helix-loop-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0019901//GO:0046983//GO:0003700 protein kinase binding//protein dimerization activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2588 Predicted DNA-binding protein Cluster-8309.49900 BF_2 77.00 3.72 1152 193878327 ACF25908.1 283 1.1e-22 crustin-2 [Eriocheir sinensis]>gi|239909562|gb|ACS32493.1| crustin III [Eriocheir sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49901 BF_2 133.95 1.54 3932 270014491 EFA10939.1 2273 6.9e-253 hypothetical protein TcasGA2_TC001770 [Tribolium castaneum] 751473836 XM_011193984.1 157 9.45964e-74 PREDICTED: Bactrocera cucurbitae endochitinase (LOC105218422), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 P36362 1808 2.4e-200 Endochitinase OS=Manduca sexta PE=2 SV=1 PF01757//PF00704//PF01607 Acyltransferase family//Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0004553//GO:0008061//GO:0016747 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005576 extracellular region -- -- Cluster-8309.49902 BF_2 206.37 2.27 4096 270014491 EFA10939.1 1976 2.0e-218 hypothetical protein TcasGA2_TC001770 [Tribolium castaneum] 751473836 XM_011193984.1 157 9.85784e-74 PREDICTED: Bactrocera cucurbitae endochitinase (LOC105218422), mRNA K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 P36362 1683 7.7e-186 Endochitinase OS=Manduca sexta PE=2 SV=1 PF01607//PF00704//PF03427//PF01757 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Carbohydrate binding domain (family 19)//Acyltransferase family GO:0006030//GO:0006032//GO:0005975 chitin metabolic process//chitin catabolic process//carbohydrate metabolic process GO:0004553//GO:0008061//GO:0016747 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005576 extracellular region KOG2806 Chitinase Cluster-8309.49903 BF_2 42.77 0.40 4722 642933239 XP_008197324.1 185 1.1e-10 PREDICTED: titin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49904 BF_2 7.38 0.31 1293 642938395 XP_971552.2 279 3.7e-22 PREDICTED: probable oligoribonuclease isoform X1 [Tribolium castaneum] -- -- -- -- -- K13288 orn, REX2, REXO2 oligoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K13288 Q9VCI0 232 4.3e-18 Probable oligoribonuclease OS=Drosophila melanogaster GN=CG10214 PE=1 SV=1 PF08395//PF02949 7tm Chemosensory receptor//7tm Odorant receptor GO:0007187//GO:0050909//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of taste//sensory perception of smell GO:0005549//GO:0004984 odorant binding//olfactory receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3242 Oligoribonuclease (3'->5' exoribonuclease) Cluster-8309.49906 BF_2 19.91 0.81 1313 478260591 ENN80294.1 316 1.9e-26 hypothetical protein YQE_03287, partial [Dendroctonus ponderosae]>gi|546685277|gb|ERL94804.1| hypothetical protein D910_12078 [Dendroctonus ponderosae] -- -- -- -- -- K12176 COPS2, CSN2, TRIP15 COP9 signalosome complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12176 Q6IR75 292 4.8e-25 COP9 signalosome complex subunit 2 (Fragment) OS=Xenopus laevis GN=csn2 PE=2 SV=1 PF01399 PCI domain -- -- GO:0005515 protein binding -- -- KOG1464 COP9 signalosome, subunit CSN2 Cluster-8309.49907 BF_2 266.08 7.29 1814 801375161 XP_012063342.1 2126 3.5e-236 PREDICTED: COP9 signalosome complex subunit 2 [Atta cephalotes] 807038124 XM_004533924.2 381 0 PREDICTED: Ceratitis capitata COP9 signalosome complex subunit 2 (LOC101459187), mRNA K12176 COPS2, CSN2, TRIP15 COP9 signalosome complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12176 Q94899 2025 7.5e-226 COP9 signalosome complex subunit 2 OS=Drosophila melanogaster GN=alien PE=1 SV=2 PF13176//PF01399 Tetratricopeptide repeat//PCI domain -- -- GO:0005515 protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.49910 BF_2 128.43 0.71 7879 642918163 XP_008191393.1 2589 3.1e-289 PREDICTED: mucin-22 isoform X3 [Tribolium castaneum] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 819 2.3e-85 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704//PF01607 Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain GO:0005975//GO:0006030 carbohydrate metabolic process//chitin metabolic process GO:0008061//GO:0004553 chitin binding//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0005576 extracellular region -- -- Cluster-8309.49912 BF_2 6.00 0.92 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49914 BF_2 399.83 9.73 2007 332374266 AEE62274.1 1745 5.9e-192 unknown [Dendroctonus ponderosae]>gi|546680061|gb|ERL90416.1| hypothetical protein D910_07765 [Dendroctonus ponderosae] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 P17248 1497 1.4e-164 Tryptophan--tRNA ligase, cytoplasmic OS=Bos taurus GN=WARS PE=1 SV=3 PF00579 tRNA synthetases class I (W and Y) GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0005524//GO:0000166 aminoacyl-tRNA ligase activity//ATP binding//nucleotide binding -- -- KOG2145 Cytoplasmic tryptophanyl-tRNA synthetase Cluster-8309.49915 BF_2 56.66 0.72 3601 189234531 XP_967948.2 893 6.6e-93 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 711 3.5e-73 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF03522//PF00324 Amino acid permease//Solute carrier family 12//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0003333//GO:0006811 transmembrane transport//amino acid transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215 amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.49921 BF_2 21.00 0.42 2371 759064429 XP_011341618.1 885 3.7e-92 PREDICTED: uncharacterized protein LOC105281809 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- B0BN95 137 8.2e-07 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.49924 BF_2 128.93 1.66 3529 642922915 XP_008200450.1 3979 0.0e+00 PREDICTED: dynamin-like 120 kDa protein, mitochondrial isoform X1 [Tribolium castaneum]>gi|270006550|gb|EFA02998.1| hypothetical protein TcasGA2_TC010420 [Tribolium castaneum] 642922916 XM_008202229.1 385 0 PREDICTED: Tribolium castaneum dynamin-like 120 kDa protein, mitochondrial (LOC660454), transcript variant X2, mRNA K17079 OPA1 optic atrophy protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17079 Q5F499 2457 1.2e-275 Dynamin-like 120 kDa protein, mitochondrial OS=Gallus gallus GN=OPA1 PE=2 SV=1 PF01926//PF13304//PF06305//PF08477//PF00071//PF02421 50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Protein of unknown function (DUF1049)//Ras of Complex, Roc, domain of DAPkinase//Ras family//Ferrous iron transport protein B GO:0006184//GO:0007264//GO:0015684 obsolete GTP catabolic process//small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005524//GO:0003924//GO:0005525 ferrous iron transmembrane transporter activity//ATP binding//GTPase activity//GTP binding GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane KOG0447 Dynamin-like GTP binding protein Cluster-8309.49930 BF_2 308.00 23.91 826 332374356 AEE62319.1 795 3.5e-82 unknown [Dendroctonus ponderosae] -- -- -- -- -- K08597 SENP8, NEDP1, DEN1 sentrin-specific protease 8 http://www.genome.jp/dbget-bin/www_bget?ko:K08597 Q5FVJ8 358 6.8e-33 Sentrin-specific protease 8 OS=Rattus norvegicus GN=Senp8 PE=2 SV=1 PF02902 Ulp1 protease family, C-terminal catalytic domain GO:0006508 proteolysis GO:0008234 cysteine-type peptidase activity -- -- KOG3246 Sentrin-specific cysteine protease (Ulp1 family) Cluster-8309.49931 BF_2 14.17 0.49 1487 642932789 XP_008196985.1 332 3.1e-28 PREDICTED: fibroblast growth factor 1-like [Tribolium castaneum]>gi|270012810|gb|EFA09258.1| fibroblast growth factor 1 [Tribolium castaneum] -- -- -- -- -- K18496 FGF1 fibroblast growth factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K18496 Q7SIF8 196 7.4e-14 Fibroblast growth factor 1 (Fragment) OS=Notophthalmus viridescens GN=fgf1 PE=1 SV=1 PF06268//PF00167//PF00340 Fascin domain//Fibroblast growth factor//Interleukin-1 / 18 GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0030674//GO:0008083//GO:0051015 protein binding, bridging//growth factor activity//actin filament binding GO:0005615 extracellular space -- -- Cluster-8309.49932 BF_2 319.00 42.79 599 91088435 XP_967919.1 560 4.5e-55 PREDICTED: ragulator complex protein LAMTOR2 homolog [Tribolium castaneum]>gi|270011751|gb|EFA08199.1| hypothetical protein TcasGA2_TC005826 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V8I2 479 4.6e-47 Ragulator complex protein LAMTOR2 homolog OS=Drosophila melanogaster GN=CG5189 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4107 MP1 adaptor interacting protein P14 Cluster-8309.49934 BF_2 363.69 1.46 10743 642926389 XP_008194905.1 4856 0.0e+00 PREDICTED: citron Rho-interacting kinase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O14578 2078 3.2e-231 Citron Rho-interacting kinase OS=Homo sapiens GN=CIT PE=1 SV=2 PF07714//PF00069//PF15367//PF00827//PF00130//PF13851//PF00433//PF01326//PF00391//PF09377 Protein tyrosine kinase//Protein kinase domain//Calcium-binding and spermatid-specific protein 1//Ribosomal L15//Phorbol esters/diacylglycerol binding domain (C1 domain)//Growth-arrest specific micro-tubule binding//Protein kinase C terminal domain//Pyruvate phosphate dikinase, PEP/pyruvate binding domain//PEP-utilising enzyme, mobile domain//SBDS protein C-terminal domain GO:0006468//GO:0009069//GO:0035556//GO:0042254//GO:0007283//GO:0048870//GO:0016310//GO:0006412 protein phosphorylation//serine family amino acid metabolic process//intracellular signal transduction//ribosome biogenesis//spermatogenesis//cell motility//phosphorylation//translation GO:0005524//GO:0004674//GO:0003735//GO:0016772//GO:0016301//GO:0004672//GO:0005509 ATP binding//protein serine/threonine kinase activity//structural constituent of ribosome//transferase activity, transferring phosphorus-containing groups//kinase activity//protein kinase activity//calcium ion binding GO:0031514//GO:0005840 motile cilium//ribosome KOG0612 Rho-associated, coiled-coil containing protein kinase Cluster-8309.49938 BF_2 297.40 1.69 7656 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 8.0e-261 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF01344//PF00651//PF07646 Kelch motif//BTB/POZ domain//Kelch motif -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.49939 BF_2 1314.73 6.27 9059 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 9.4e-261 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF07646//PF00651//PF01667//PF01344//PF00856 Kelch motif//BTB/POZ domain//Ribosomal protein S27//Kelch motif//SET domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840//GO:0005622 ribosome//intracellular KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.4994 BF_2 10.47 0.61 1007 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49945 BF_2 402.00 6.83 2748 642930650 XP_008199210.1 1816 4.7e-200 PREDICTED: ubiquitin carboxyl-terminal hydrolase 30 [Tribolium castaneum] -- -- -- -- -- K11851 USP30 ubiquitin carboxyl-terminal hydrolase 30 http://www.genome.jp/dbget-bin/www_bget?ko:K11851 Q9W462 475 6.1e-46 Ubiquitin carboxyl-terminal hydrolase 30 homolog OS=Drosophila melanogaster GN=CG3016 PE=2 SV=1 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0036459//GO:0032183//GO:0070140 ubiquitinyl hydrolase activity//SUMO binding//SUMO-specific isopeptidase activity -- -- KOG1867 Ubiquitin-specific protease Cluster-8309.49947 BF_2 18.01 1.64 746 332372780 AEE61532.1 200 3.1e-13 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JHY2 158 9.5e-10 Sideroflexin-3 OS=Rattus norvegicus GN=Sfxn3 PE=2 SV=1 PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.49949 BF_2 35.45 0.39 4111 642913773 XP_008201155.1 4269 0.0e+00 PREDICTED: C-myc promoter-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6H8H2 2020 6.4e-225 DENN domain-containing protein 4C OS=Mus musculus GN=Dennd4c PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2127 Calmodulin-binding protein CRAG, contains DENN domain Cluster-8309.49950 BF_2 5.32 0.44 795 645004771 XP_008210751.1 420 1.0e-38 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100116128 [Nasonia vitripennis] 194893319 XM_001977817.1 74 2.54893e-28 Drosophila erecta GG19272 (Dere\GG19272), mRNA -- -- -- -- -- -- -- -- PF05818 Enterobacterial TraT complement resistance protein GO:0046999 regulation of conjugation -- -- GO:0019867 outer membrane -- -- Cluster-8309.49951 BF_2 14.60 0.39 1851 642925690 XP_008194671.1 1357 5.3e-147 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1161 1.2e-125 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.49952 BF_2 37.37 0.40 4237 91086089 XP_967008.1 1099 1.0e-116 PREDICTED: XK-related protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5GH59 276 1.1e-22 XK-related protein 4 OS=Rattus norvegicus GN=Xkr4 PE=2 SV=1 PF09815 XK-related protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49953 BF_2 27.88 0.33 3776 546676381 ERL87403.1 680 3.5e-68 hypothetical protein D910_04798 [Dendroctonus ponderosae] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 Q9FPH3 391 4.6e-36 Probable low-specificity L-threonine aldolase 2 OS=Arabidopsis thaliana GN=THA2 PE=1 SV=1 PF08122//PF01212//PF01053 NADH-ubiquinone oxidoreductase B12 subunit family//Beta-eliminating lyase//Cys/Met metabolism PLP-dependent enzyme GO:0006520//GO:0022900 cellular amino acid metabolic process//electron transport chain GO:0016829//GO:0030170 lyase activity//pyridoxal phosphate binding GO:0005747//GO:0005739 mitochondrial respiratory chain complex I//mitochondrion KOG1368 Threonine aldolase Cluster-8309.49954 BF_2 6.00 0.36 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01350 Flavivirus non-structural protein NS4A GO:0016032//GO:0016070 viral process//RNA metabolic process -- -- GO:0019012 virion -- -- Cluster-8309.49956 BF_2 227.63 2.65 3883 642914519 XP_008201711.1 1016 3.9e-107 PREDICTED: post-GPI attachment to proteins factor 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VWK6 648 7.5e-66 Post-GPI attachment to proteins factor 2-like OS=Drosophila melanogaster GN=CG7990 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.49957 BF_2 93.97 2.04 2214 642929686 XP_008195936.1 615 7.0e-61 PREDICTED: uncharacterized protein LOC103313713 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49958 BF_2 180.45 1.63 4926 478251097 ENN71573.1 1380 3.1e-149 hypothetical protein YQE_11673, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9WU40 209 7.7e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.49960 BF_2 119.18 0.92 5705 91080703 XP_975295.1 987 1.3e-103 PREDICTED: uncharacterized protein LOC664189 [Tribolium castaneum]>gi|270005858|gb|EFA02306.1| hypothetical protein TcasGA2_TC007972 [Tribolium castaneum] 462358939 APGK01029925.1 99 2.40317e-41 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- Q8BJ05 260 1.1e-20 Zinc finger CCCH domain-containing protein 14 OS=Mus musculus GN=Zc3h14 PE=1 SV=1 PF01480//PF05830//PF03595 PWI domain//Nodulation protein Z (NodZ)//Voltage-dependent anion channel GO:0006397//GO:0009312//GO:0055085//GO:0009877 mRNA processing//oligosaccharide biosynthetic process//transmembrane transport//nodulation GO:0016758 transferase activity, transferring hexosyl groups GO:0016021 integral component of membrane KOG3702 Nuclear polyadenylated RNA binding protein Cluster-8309.49962 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49965 BF_2 17.89 0.46 1910 478250804 ENN71296.1 674 8.7e-68 hypothetical protein YQE_12221, partial [Dendroctonus ponderosae] -- -- -- -- -- K10976 ERO1LB ERO1-like protein beta http://www.genome.jp/dbget-bin/www_bget?ko:K10976 Q9V3A6 487 1.7e-47 Ero1-like protein OS=Drosophila melanogaster GN=Ero1L PE=2 SV=2 PF04137 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) GO:0055114 oxidation-reduction process GO:0003756//GO:0016671 protein disulfide isomerase activity//oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor GO:0005783 endoplasmic reticulum KOG2608 Endoplasmic reticulum membrane-associated oxidoreductin involved in disulfide bond formation Cluster-8309.49970 BF_2 3313.72 62.67 2499 478250393 ENN70888.1 1982 2.4e-219 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 663 8.8e-68 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF00107//PF03404 Zinc-binding dehydrogenase//Mo-co oxidoreductase dimerisation domain GO:0055114 oxidation-reduction process GO:0016491//GO:0030151 oxidoreductase activity//molybdenum ion binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.49971 BF_2 146.44 2.95 2366 642913809 XP_008201168.1 397 1.4e-35 PREDICTED: putative WEB family protein At1g65010, chloroplastic [Tribolium castaneum]>gi|270001664|gb|EEZ98111.1| hypothetical protein TcasGA2_TC000528 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6P9Q6 173 5.5e-11 FK506-binding protein 15 OS=Mus musculus GN=Fkbp15 PE=1 SV=2 PF10473//PF09177//PF04111//PF08650 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//Autophagy protein Apg6//DASH complex subunit Dad4 GO:0008608//GO:0048193//GO:0006914 attachment of spindle microtubules to kinetochore//Golgi vesicle transport//autophagy GO:0042803//GO:0008134//GO:0045502 protein homodimerization activity//transcription factor binding//dynein binding GO:0016020//GO:0042729//GO:0030286//GO:0072686//GO:0005667 membrane//DASH complex//dynein complex//mitotic spindle//transcription factor complex -- -- Cluster-8309.49976 BF_2 773.70 10.44 3386 91081645 XP_968283.1 984 1.7e-103 PREDICTED: uncharacterized protein LOC656681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07062 Clc-like -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.49978 BF_2 26.11 0.38 3144 688549490 XP_009298860.1 580 1.1e-56 PREDICTED: gastrula zinc finger protein XlCGF57.1-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9EQB9 575 1.8e-57 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF04810//PF00412//PF13912//PF14972//PF00096//PF13465//PF09174 Sec23/Sec24 zinc finger//LIM domain//C2H2-type zinc finger//Mitochondrial morphogenesis regulator//Zinc finger, C2H2 type//Zinc-finger double domain//Maf1 regulator GO:0006886//GO:0016480//GO:0006888//GO:0007005 intracellular protein transport//negative regulation of transcription from RNA polymerase III promoter//ER to Golgi vesicle-mediated transport//mitochondrion organization GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0030127//GO:0031305 COPII vesicle coat//integral component of mitochondrial inner membrane -- -- Cluster-8309.49979 BF_2 27.00 1.87 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49980 BF_2 13.00 1.16 754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49981 BF_2 60.22 1.03 2724 688549490 XP_009298860.1 543 1.9e-52 PREDICTED: gastrula zinc finger protein XlCGF57.1-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9EQB9 532 1.5e-52 Zinc finger protein 287 OS=Mus musculus GN=Znf287 PE=2 SV=2 PF05191//PF13912//PF00412//PF09174//PF00096//PF13465 Adenylate kinase, active site lid//C2H2-type zinc finger//LIM domain//Maf1 regulator//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006144//GO:0046034//GO:0016480 purine nucleobase metabolic process//ATP metabolic process//negative regulation of transcription from RNA polymerase III promoter GO:0008270//GO:0046872//GO:0004017 zinc ion binding//metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.49982 BF_2 228.88 4.31 2511 642936826 XP_008197806.1 2492 1.8e-278 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X1 [Tribolium castaneum]>gi|270000937|gb|EEZ97384.1| hypothetical protein TcasGA2_TC011210 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 1889 6.1e-210 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00628//PF00130//PF00622 PHD-finger//Phorbol esters/diacylglycerol binding domain (C1 domain)//SPRY domain GO:0035556 intracellular signal transduction GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.49991 BF_2 13.14 1.76 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.49994 BF_2 1575.00 43.70 1795 237681128 NP_001153709.1 2550 2.4e-285 eukaryotic initiation factor 3 p66 subunit [Tribolium castaneum] 766940977 XM_011504807.1 209 5.29985e-103 PREDICTED: Ceratosolen solmsi marchali eukaryotic translation initiation factor 3 subunit D (LOC105366385), mRNA K03251 EIF3D translation initiation factor 3 subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K03251 Q7QBW3 2128 8.4e-238 Eukaryotic translation initiation factor 3 subunit D OS=Anopheles gambiae GN=eIF3-S7 PE=3 SV=3 PF10505//PF05091//PF01788 NMDA receptor-regulated gene protein 2 C-terminus//Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)//PsbJ GO:0015979//GO:0006446 photosynthesis//regulation of translational initiation GO:0003743 translation initiation factor activity GO:0008023//GO:0005840//GO:0016020//GO:0005852//GO:0009539//GO:0005737//GO:0009523 transcription elongation factor complex//ribosome//membrane//eukaryotic translation initiation factor 3 complex//photosystem II reaction center//cytoplasm//photosystem II KOG2479 Translation initiation factor 3, subunit d (eIF-3d) Cluster-8309.49995 BF_2 186.05 3.22 2703 642929864 XP_008196005.1 2407 1.4e-268 PREDICTED: cactin isoform X2 [Tribolium castaneum] 696122558 KF828752.1 126 1.10684e-56 Rhipicephalus microplus Cactin mRNA, partial cds -- -- -- -- Q9VR99 1610 1.5e-177 Cactin OS=Drosophila melanogaster GN=cactin PE=1 SV=3 PF09732 Cactus-binding C-terminus of cactin protein -- -- GO:0005515 protein binding -- -- KOG2370 Cactin Cluster-8309.49996 BF_2 162.55 1.16 6160 189240093 XP_972388.2 1454 1.0e-157 PREDICTED: myosin heavy chain, clone 203 isoform X1 [Tribolium castaneum]>gi|270012237|gb|EFA08685.1| hypothetical protein TcasGA2_TC006355 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05929//PF04048//PF01465//PF04508//PF10186 Phage capsid scaffolding protein (GPO) serine peptidase//Sec8 exocyst complex component specific domain//GRIP domain//Viral A-type inclusion protein repeat//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0019069//GO:0010508//GO:0000042//GO:0015031//GO:0006904//GO:0016032 viral capsid assembly//positive regulation of autophagy//protein targeting to Golgi//protein transport//vesicle docking involved in exocytosis//viral process GO:0005515 protein binding GO:0000145 exocyst -- -- Cluster-8309.49998 BF_2 163.10 6.48 1340 642933482 XP_008197436.1 1172 1.1e-125 PREDICTED: luc7-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95232 670 7.3e-69 Luc7-like protein 3 OS=Homo sapiens GN=LUC7L3 PE=1 SV=2 PF08027//PF03194//PF05887 Albumin I chain b//LUC7 N_terminus//Procyclic acidic repetitive protein (PARP) GO:0009405//GO:0006376 pathogenesis//mRNA splice site selection GO:0045735//GO:0003729 nutrient reservoir activity//mRNA binding GO:0005685//GO:0016020 U1 snRNP//membrane KOG0796 Spliceosome subunit Cluster-8309.49999 BF_2 165.90 4.25 1921 642933482 XP_008197436.1 1172 1.6e-125 PREDICTED: luc7-like protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95232 670 1.0e-68 Luc7-like protein 3 OS=Homo sapiens GN=LUC7L3 PE=1 SV=2 PF05887//PF03194//PF08027 Procyclic acidic repetitive protein (PARP)//LUC7 N_terminus//Albumin I chain b GO:0009405//GO:0006376 pathogenesis//mRNA splice site selection GO:0003729//GO:0045735 mRNA binding//nutrient reservoir activity GO:0005685//GO:0016020 U1 snRNP//membrane KOG0796 Spliceosome subunit Cluster-8309.50000 BF_2 151.00 2.72 2606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50001 BF_2 24.79 1.61 931 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50002 BF_2 38.37 1.24 1580 815793737 XP_012217495.1 220 3.2e-15 PREDICTED: mucin-17-like [Linepithema humile] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50003 BF_2 175.00 7.57 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50005 BF_2 72.90 1.59 2201 642912820 XP_008201266.1 477 7.0e-45 PREDICTED: DNA damage-regulated autophagy modulator protein 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 292 8.1e-25 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4320 Uncharacterized conserved protein Cluster-8309.50006 BF_2 102.41 1.84 2620 270001923 EEZ98370.1 376 4.3e-33 hypothetical protein TcasGA2_TC000828 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZC48 223 9.7e-17 DNA damage-regulated autophagy modulator protein 2 OS=Bos taurus GN=DRAM2 PE=2 SV=1 PF01825 GPCR proteolysis site, GPS, motif -- -- -- -- GO:0016020 membrane KOG4320 Uncharacterized conserved protein Cluster-8309.50009 BF_2 11.39 0.43 1387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50010 BF_2 12.61 0.56 1228 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50011 BF_2 37.00 4.87 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50012 BF_2 193.83 2.08 4188 478250013 ENN70519.1 1223 4.2e-131 hypothetical protein YQE_12695, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZPJ0 192 6.1e-13 Testis-expressed sequence 2 protein OS=Mus musculus GN=Tex2 PE=1 SV=2 PF02388//PF01280 FemAB family//Ribosomal protein L19e GO:0009252//GO:0006412//GO:0042254 peptidoglycan biosynthetic process//translation//ribosome biogenesis GO:0016755//GO:0003735 transferase activity, transferring amino-acyl groups//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2238 Uncharacterized conserved protein TEX2, contains PH domain Cluster-8309.50013 BF_2 230.06 0.93 10601 270005280 EFA01728.1 8299 0.0e+00 hypothetical protein TcasGA2_TC007308 [Tribolium castaneum] 642920256 XM_008194048.1 93 9.69062e-38 PREDICTED: Tribolium castaneum pecanex-like protein 1 (LOC664487), transcript variant X2, mRNA -- -- -- -- Q96RV3 3295 0.0e+00 Pecanex-like protein 1 OS=Homo sapiens GN=PCNX PE=1 SV=2 PF11095//PF05041//PF06753 Gem-associated protein 7 (Gemin7)//Pecanex protein (C-terminus)//Bradykinin GO:0006950//GO:0007165 response to stress//signal transduction GO:0005179 hormone activity GO:0032797//GO:0016021//GO:0005576 SMN complex//integral component of membrane//extracellular region KOG3604 Pecanex Cluster-8309.50014 BF_2 73.06 0.33 9539 270005280 EFA01728.1 8020 0.0e+00 hypothetical protein TcasGA2_TC007308 [Tribolium castaneum] 642920256 XM_008194048.1 93 8.71642e-38 PREDICTED: Tribolium castaneum pecanex-like protein 1 (LOC664487), transcript variant X2, mRNA -- -- -- -- Q96RV3 3295 0.0e+00 Pecanex-like protein 1 OS=Homo sapiens GN=PCNX PE=1 SV=2 PF05041//PF11095//PF04805//PF06753 Pecanex protein (C-terminus)//Gem-associated protein 7 (Gemin7)//E10-like protein conserved region//Bradykinin GO:0007165//GO:0006950//GO:0055114 signal transduction//response to stress//oxidation-reduction process GO:0005179//GO:0016972 hormone activity//thiol oxidase activity GO:0016021//GO:0032797//GO:0005576 integral component of membrane//SMN complex//extracellular region KOG3604 Pecanex Cluster-8309.50019 BF_2 9.00 12.34 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50020 BF_2 173.00 5.89 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50024 BF_2 172.38 4.24 1987 642920075 XP_008192196.1 1290 3.4e-139 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 793 5.9e-83 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03453 MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.50025 BF_2 292.24 4.32 3118 642920075 XP_008192196.1 1129 2.5e-120 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 742 7.6e-77 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03454//PF03453 MoeA C-terminal region (domain IV)//MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.50026 BF_2 3.00 0.48 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50027 BF_2 19.00 0.42 2182 270006380 EFA02828.1 295 8.8e-24 insulin-like growth factor receptor [Tribolium castaneum]>gi|570932717|gb|AHF20215.1| insulin like receptor 2 [Tribolium castaneum] -- -- -- -- -- K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q9WTL4 239 1.1e-18 Insulin receptor-related protein OS=Mus musculus GN=Insrr PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50028 BF_2 182.62 0.75 10537 270006380 EFA02828.1 2538 3.4e-283 insulin-like growth factor receptor [Tribolium castaneum]>gi|570932717|gb|AHF20215.1| insulin like receptor 2 [Tribolium castaneum] 471364329 XM_004372657.1 83 3.48885e-32 PREDICTED: Trichechus manatus latirostris insulin-like growth factor 1 receptor (LOC101355333), mRNA K05087 IGF1R insulin-like growth factor 1 receptor http://www.genome.jp/dbget-bin/www_bget?ko:K05087 Q60751 1871 3.1e-207 Insulin-like growth factor 1 receptor OS=Mus musculus GN=Igf1r PE=1 SV=3 PF16656//PF08727//PF00757//PF00909//PF00041//PF00069//PF07714 Purple acid Phosphatase, N-terminal domain//Poliovirus 3A protein like//Furin-like cysteine rich region//Ammonium Transporter Family//Fibronectin type III domain//Protein kinase domain//Protein tyrosine kinase GO:0015696//GO:0006144//GO:0006508//GO:0006771//GO:0007169//GO:0019497//GO:0006468 ammonium transport//purine nucleobase metabolic process//proteolysis//riboflavin metabolic process//transmembrane receptor protein tyrosine kinase signaling pathway//hexachlorocyclohexane metabolic process//protein phosphorylation GO:0005515//GO:0003968//GO:0017111//GO:0004714//GO:0004672//GO:0046872//GO:0004197//GO:0005524//GO:0008519//GO:0003993 protein binding//RNA-directed RNA polymerase activity//nucleoside-triphosphatase activity//transmembrane receptor protein tyrosine kinase activity//protein kinase activity//metal ion binding//cysteine-type endopeptidase activity//ATP binding//ammonium transmembrane transporter activity//acid phosphatase activity GO:0016020//GO:0031379 membrane//RNA-directed RNA polymerase complex KOG3796 Ammonium transporter RHBG Cluster-8309.50029 BF_2 55.87 0.45 5499 642920075 XP_008192196.1 1113 3.1e-118 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 703 4.5e-72 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03453 MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.50033 BF_2 88.20 1.07 3720 332372780 AEE61532.1 1006 5.4e-106 unknown [Dendroctonus ponderosae] 564241437 XM_006277474.1 68 2.66933e-24 PREDICTED: Alligator mississippiensis sideroflexin-1-like (LOC102569899), mRNA -- -- -- -- Q5E9M8 773 2.3e-80 Sideroflexin-1 OS=Bos taurus GN=SFXN1 PE=2 SV=3 PF03820 Tricarboxylate carrier GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.50034 BF_2 34.58 0.52 3066 478257160 ENN77323.1 1838 1.5e-202 hypothetical protein YQE_06149, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IVI9 341 2.4e-30 Nostrin OS=Homo sapiens GN=NOSTRIN PE=1 SV=2 PF02185 Hr1 repeat GO:0007165 signal transduction -- -- -- -- KOG3158 HSP90 co-chaperone p23 Cluster-8309.50039 BF_2 1000.39 46.46 1188 270008834 EFA05282.1 830 4.4e-86 hypothetical protein TcasGA2_TC015439 [Tribolium castaneum] -- -- -- -- -- K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02599 388 3.2e-36 Calmodulin OS=Dictyostelium discoideum GN=calA PE=1 SV=3 PF13499//PF10591//PF13833//PF00036//PF13405//PF12763//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF hand//EF-hand domain//Cytoskeletal-regulatory complex EF hand//EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.50040 BF_2 14.49 0.44 1672 642921818 XP_008199331.1 193 4.5e-12 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.50044 BF_2 186.87 1.94 4322 642925718 XP_973763.2 936 8.2e-98 PREDICTED: facilitated trehalose transporter Tret1-2 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4GAP7 488 3.0e-47 Facilitated trehalose transporter Tret1 OS=Drosophila persimilis GN=Tret1 PE=3 SV=2 PF00083//PF10483//PF07690//PF05493 Sugar (and other) transporter//Elongator subunit Iki1//Major Facilitator Superfamily//ATP synthase subunit H GO:0015992//GO:0015991//GO:0055085 proton transport//ATP hydrolysis coupled proton transport//transmembrane transport GO:0015078//GO:0022857 hydrogen ion transmembrane transporter activity//transmembrane transporter activity GO:0033588//GO:0033179//GO:0016021 Elongator holoenzyme complex//proton-transporting V-type ATPase, V0 domain//integral component of membrane -- -- Cluster-8309.50045 BF_2 199.78 8.10 1319 642918845 XP_008191611.1 681 9.3e-69 PREDICTED: phosphoglycolate phosphatase 2-like [Tribolium castaneum]>gi|270005689|gb|EFA02137.1| hypothetical protein TcasGA2_TC007787 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 314 1.4e-27 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 PF02310 B12 binding domain -- -- GO:0046872//GO:0031419 metal ion binding//cobalamin binding -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.50046 BF_2 21.00 1.25 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.50048 BF_2 273.29 2.45 4957 642910200 XP_008198377.1 2478 1.5e-276 PREDICTED: N-alpha-acetyltransferase 35, NatC auxiliary subunit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZHV2 1716 1.4e-189 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Gallus gallus GN=NAA35 PE=2 SV=1 PF08336//PF08287//PF01442//PF02050 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Spc19//Apolipoprotein A1/A4/E domain//Flagellar FliJ protein GO:0042157//GO:0006935//GO:0006869//GO:0071973//GO:0006560//GO:0008608//GO:0055114//GO:0006525//GO:0018401 lipoprotein metabolic process//chemotaxis//lipid transport//bacterial-type flagellum-dependent cell motility//proline metabolic process//attachment of spindle microtubules to kinetochore//oxidation-reduction process//arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline GO:0003774//GO:0008289//GO:0004656//GO:0016702 motor activity//lipid binding//procollagen-proline 4-dioxygenase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005576//GO:0016020//GO:0005783//GO:0042729//GO:0009288//GO:0005876 extracellular region//membrane//endoplasmic reticulum//DASH complex//bacterial-type flagellum//spindle microtubule KOG2343 Glucose-repressible protein and related proteins Cluster-8309.50050 BF_2 57.44 0.37 6762 642940098 XP_008192969.1 1251 3.8e-134 PREDICTED: excitatory amino acid transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 Q10901 602 2.8e-60 Excitatory amino acid transporter OS=Caenorhabditis elegans GN=glt-1 PE=1 SV=2 PF01585//PF00375 G-patch domain//Sodium:dicarboxylate symporter family GO:0006835//GO:0006812//GO:0006820 dicarboxylic acid transport//cation transport//anion transport GO:0003676//GO:0017153 nucleic acid binding//sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.50051 BF_2 136.49 1.27 4781 642923482 XP_008193528.1 1562 2.3e-170 PREDICTED: hyccin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BYI3 417 5.7e-39 Hyccin OS=Homo sapiens GN=FAM126A PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.50052 BF_2 17.28 0.43 1985 642923487 XP_008193531.1 316 2.9e-26 PREDICTED: RNA binding protein fox-1 homolog 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50053 BF_2 20.93 4.92 465 546677542 ERL88361.1 236 1.3e-17 hypothetical protein D910_05748, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01426 BAH domain -- -- GO:0003682 chromatin binding GO:0000785 chromatin -- -- Cluster-8309.50056 BF_2 145.07 4.03 1794 478249914 ENN70421.1 958 9.6e-101 hypothetical protein YQE_12926, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P78524 186 1.3e-12 Suppression of tumorigenicity 5 protein OS=Homo sapiens GN=ST5 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50058 BF_2 3.85 0.31 815 91092902 XP_971056.1 495 2.1e-47 PREDICTED: N-acetyltransferase 9-like protein [Tribolium castaneum]>gi|270003097|gb|EEZ99544.1| hypothetical protein TcasGA2_TC000126 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7SLC8 273 4.8e-23 N-acetyltransferase 9-like protein OS=Nematostella vectensis GN=nat9 PE=3 SV=1 PF13302 Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- KOG4135 Predicted phosphoglucosamine acetyltransferase Cluster-8309.50059 BF_2 93.00 5.09 1051 642933799 XP_008197333.1 1000 7.5e-106 PREDICTED: PIH1 domain-containing protein 1 [Tribolium castaneum]>gi|270013593|gb|EFA10041.1| hypothetical protein TcasGA2_TC012213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZWY2 469 1.2e-45 PIH1 domain-containing protein 1 OS=Xenopus laevis GN=pih1d1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50063 BF_2 217.00 13.55 957 478254555 ENN74798.1 694 2.1e-70 hypothetical protein YQE_08571, partial [Dendroctonus ponderosae]>gi|546681658|gb|ERL91709.1| hypothetical protein D910_09036 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q92626 207 2.5e-15 Peroxidasin homolog OS=Homo sapiens GN=PXDN PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50064 BF_2 94.29 1.98 2279 91091974 XP_968950.1 1069 1.6e-113 PREDICTED: protein prenyltransferase alpha subunit repeat-containing protein 1-B [Tribolium castaneum]>gi|270001151|gb|EEZ97598.1| hypothetical protein TcasGA2_TC011467 [Tribolium castaneum] -- -- -- -- -- K14137 PTAR1 protein prenyltransferase alpha subunit repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14137 A1L3L1 385 1.4e-35 Protein prenyltransferase alpha subunit repeat-containing protein 1-B (Fragment) OS=Xenopus laevis GN=ptar1-b PE=2 SV=1 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- -- -- Cluster-8309.50066 BF_2 219.00 4.55 2299 91094257 XP_969374.1 1055 6.9e-112 PREDICTED: BUD13 homolog [Tribolium castaneum]>gi|270016259|gb|EFA12705.1| hypothetical protein TcasGA2_TC002339 [Tribolium castaneum] -- -- -- -- -- K13106 BUD13, CWC26 pre-mRNA-splicing factor CWC26 http://www.genome.jp/dbget-bin/www_bget?ko:K13106 P30640 569 6.4e-57 BUD13 homolog OS=Caenorhabditis elegans GN=R08D7.1 PE=3 SV=1 PF04139//PF01176 Rad9//Translation initiation factor 1A / IF-1 GO:0006446//GO:0006413//GO:0000077 regulation of translational initiation//translational initiation//DNA damage checkpoint GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005840//GO:0030896 ribosome//checkpoint clamp complex KOG2654 Uncharacterized conserved protein Cluster-8309.50067 BF_2 68.24 0.58 5182 91083631 XP_970382.1 3673 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 2.06143e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 Q13423 2881 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Homo sapiens GN=NNT PE=1 SV=3 PF01752//PF02826//PF03188//PF00205//PF00236//PF00107//PF02233//PF02456//PF00005 Collagenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Thiamine pyrophosphate enzyme, central domain//Glycoprotein hormone//Zinc-binding dehydrogenase//NAD(P) transhydrogenase beta subunit//Adenovirus IVa2 protein//ABC transporter GO:0007165//GO:0019083//GO:0046497//GO:0006769//GO:0015992//GO:0055114//GO:0006508 signal transduction//viral transcription//nicotinate nucleotide metabolic process//nicotinamide metabolic process//proton transport//oxidation-reduction process//proteolysis GO:0005524//GO:0008750//GO:0008270//GO:0016887//GO:0004252//GO:0050661//GO:0051287//GO:0005179//GO:0000287//GO:0030976 ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//zinc ion binding//ATPase activity//serine-type endopeptidase activity//NADP binding//NAD binding//hormone activity//magnesium ion binding//thiamine pyrophosphate binding GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.50068 BF_2 25.66 0.37 3223 642925144 XP_008194444.1 1180 3.1e-126 PREDICTED: WSCD family member AGAP003962 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16WU7 876 2.3e-92 WSCD family member AAEL009094 OS=Aedes aegypti GN=AAEL009094 PE=3 SV=1 PF00685//PF01356 Sulfotransferase domain//Alpha amylase inhibitor -- -- GO:0015066//GO:0008146 alpha-amylase inhibitor activity//sulfotransferase activity -- -- -- -- Cluster-8309.50070 BF_2 135.22 2.29 2755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50072 BF_2 48.02 5.88 629 642917454 XP_008191207.1 338 2.6e-29 PREDICTED: uncharacterized protein LOC655754 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14722 Ki-ras-induced actin-interacting protein-IP3R-interacting domain GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.50073 BF_2 541.76 8.16 3065 91079466 XP_967409.1 421 3.0e-38 PREDICTED: uncharacterized protein LOC655754 isoform X3 [Tribolium castaneum]>gi|270003452|gb|EEZ99899.1| hypothetical protein TcasGA2_TC002683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14722 Ki-ras-induced actin-interacting protein-IP3R-interacting domain GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.50074 BF_2 184.80 8.07 1245 546685212 ERL94739.1 1007 1.4e-106 hypothetical protein D910_12013 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N954 397 3.1e-37 G patch domain-containing protein 11 OS=Homo sapiens GN=GPATCH11 PE=1 SV=3 PF01585//PF08941 G-patch domain//USP8 interacting GO:0016567 protein ubiquitination GO:0016881//GO:0031386//GO:0003676 acid-amino acid ligase activity//protein tag//nucleic acid binding -- -- KOG1994 Predicted RNA binding protein, contains G-patch and Zn-finger domains Cluster-8309.50078 BF_2 57.24 0.57 4512 189239531 XP_975588.2 1723 4.7e-189 PREDICTED: myb-related protein B isoform X1 [Tribolium castaneum] 817200908 XM_012420764.1 89 6.87286e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 8.5e-45 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.50079 BF_2 134.14 1.12 5280 270014457 EFA10905.1 248 6.0e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.50081 BF_2 6.00 2.16 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50082 BF_2 394.80 3.85 4578 91089365 XP_973210.1 1738 8.7e-191 PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Tribolium castaneum]>gi|642933115|ref|XP_008197263.1| PREDICTED: guanine nucleotide-binding protein G(o) subunit alpha [Tribolium castaneum]>gi|270012525|gb|EFA08973.1| hypothetical protein TcasGA2_TC006680 [Tribolium castaneum] 642933114 XM_008199041.1 278 6.01137e-141 PREDICTED: Tribolium castaneum guanine nucleotide-binding protein G(o) subunit alpha (LOC661989), transcript variant X2, mRNA K04630 GNAI guanine nucleotide-binding protein G(i) subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K04630 Q9XZV3 959 7.7e-102 Guanine nucleotide-binding protein G(o) subunit alpha OS=Geodia cydonium PE=2 SV=3 PF07931//PF08477//PF00025//PF04670//PF00503 Chloramphenicol phosphotransferase-like protein//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Gtr1/RagA G protein conserved region//G-protein alpha subunit GO:0007165//GO:0007186//GO:0007264 signal transduction//G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction GO:0005524//GO:0031683//GO:0016740//GO:0003924//GO:0005525//GO:0004871//GO:0019001 ATP binding//G-protein beta/gamma-subunit complex binding//transferase activity//GTPase activity//GTP binding//signal transducer activity//guanyl nucleotide binding -- -- KOG0082 G-protein alpha subunit (small G protein superfamily) Cluster-8309.50084 BF_2 10.82 0.84 828 91094899 XP_973315.1 576 8.7e-57 PREDICTED: ubiquitin-like modifier-activating enzyme 5 [Tribolium castaneum]>gi|270006537|gb|EFA02985.1| hypothetical protein TcasGA2_TC010401 [Tribolium castaneum] -- -- -- -- -- K12164 UBA5, UBE1DC1 ubiquitin-like modifier-activating enzyme 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12164 B9VJ80 530 7.7e-53 Ubiquitin-like modifier-activating enzyme 5 OS=Bombyx mori PE=2 SV=1 PF03435//PF02558//PF02826//PF03721//PF00899//PF00831//PF01494//PF02737 Saccharopine dehydrogenase NADP binding domain//Ketopantoate reductase PanE/ApbA//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//ThiF family//Ribosomal L29 protein//FAD binding domain//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain GO:0018874//GO:0006633//GO:0006412//GO:0006631//GO:0006552//GO:0015940//GO:0006574//GO:0006550//GO:0006568//GO:0006554//GO:0055114//GO:0042254 benzoate metabolic process//fatty acid biosynthetic process//translation//fatty acid metabolic process//leucine catabolic process//pantothenate biosynthetic process//valine catabolic process//isoleucine catabolic process//tryptophan metabolic process//lysine catabolic process//oxidation-reduction process//ribosome biogenesis GO:0016491//GO:0051287//GO:0008677//GO:0008641//GO:0071949//GO:0016616//GO:0003735//GO:0000166//GO:0003857//GO:0048037 oxidoreductase activity//NAD binding//2-dehydropantoate 2-reductase activity//small protein activating enzyme activity//FAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//structural constituent of ribosome//nucleotide binding//3-hydroxyacyl-CoA dehydrogenase activity//cofactor binding GO:0005622//GO:0005840 intracellular//ribosome KOG2336 Molybdopterin biosynthesis-related protein Cluster-8309.50089 BF_2 23.47 0.31 3469 91083357 XP_975102.1 2572 1.3e-287 PREDICTED: suppressor of hairless protein [Tribolium castaneum]>gi|270008236|gb|EFA04684.1| suppressor of hairless [Tribolium castaneum] 642923838 XM_970009.2 512 0 PREDICTED: Tribolium castaneum suppressor of hairless (LOC663984), mRNA K06053 RBPSUH, RBPJK recombining binding protein suppressor of hairless http://www.genome.jp/dbget-bin/www_bget?ko:K06053 P28159 2150 4.6e-240 Suppressor of hairless protein OS=Drosophila melanogaster GN=Su(H) PE=1 SV=1 PF09271//PF09270//PF01833 LAG1, DNA binding//Beta-trefoil DNA-binding domain//IPT/TIG domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0003700//GO:0000978//GO:0000982 protein binding//DNA binding//transcription factor activity, sequence-specific DNA binding//RNA polymerase II core promoter proximal region sequence-specific DNA binding//transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3743 Recombination signal binding protein-J kappa(CBF1, Su(H), HS2NF5) Cluster-8309.50090 BF_2 8.59 0.74 776 91088745 XP_975314.1 302 4.8e-25 PREDICTED: uncharacterized protein LOC664209 [Tribolium castaneum]>gi|270012304|gb|EFA08752.1| hypothetical protein TcasGA2_TC006429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50091 BF_2 11.26 1.10 715 332373440 AEE61861.1 334 8.7e-29 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GQ29 299 4.1e-26 Carboxypeptidase Q OS=Xenopus laevis GN=cpq PE=2 SV=1 PF02780 Transketolase, C-terminal domain GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.50092 BF_2 197.61 1.50 5796 642927212 XP_008195182.1 2177 1.4e-241 PREDICTED: S phase cyclin A-associated protein in the endoplasmic reticulum [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY12 677 4.9e-69 S phase cyclin A-associated protein in the endoplasmic reticulum OS=Homo sapiens GN=SCAPER PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50095 BF_2 2.00 2.25 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5010 BF_2 12.68 0.39 1633 769831193 XP_011634997.1 1729 3.4e-190 PREDICTED: synaptotagmin-7 isoform X1 [Pogonomyrmex barbatus] 768417764 XM_011551234.1 440 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 876 1.2e-92 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.50100 BF_2 19.60 0.64 1573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50102 BF_2 465.99 3.59 5724 270013632 EFA10080.1 4350 0.0e+00 hypothetical protein TcasGA2_TC012257 [Tribolium castaneum] 462320691 APGK01043568.1 65 1.91749e-22 Dendroctonus ponderosae Seq01043578, whole genome shotgun sequence K16680 ED echinoid http://www.genome.jp/dbget-bin/www_bget?ko:K16680 Q96RW7 345 1.5e-30 Hemicentin-1 OS=Homo sapiens GN=HMCN1 PE=1 SV=2 PF01108//PF06682//PF13895//PF00041 Tissue factor//SOCE-associated regulatory factor of calcium homoeostasis//Immunoglobulin domain//Fibronectin type III domain GO:2001256 regulation of store-operated calcium entry GO:0005515 protein binding GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.50105 BF_2 491.00 11.04 2147 91087583 XP_971811.1 2038 6.7e-226 PREDICTED: nicalin-1 [Tribolium castaneum]>gi|270009431|gb|EFA05879.1| hypothetical protein TcasGA2_TC008691 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NZ07 1167 2.7e-126 Nicalin-1 OS=Danio rerio GN=ncl1 PE=2 SV=1 PF05450 Nicastrin GO:0016485//GO:0006508 protein processing//proteolysis GO:0008233 peptidase activity GO:0016021 integral component of membrane KOG2526 Predicted aminopeptidases - M20/M25/M40 family Cluster-8309.50106 BF_2 55.84 0.86 3014 642916479 XP_008191061.1 1715 2.7e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 1.6e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 PF00076//PF09726 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Transmembrane protein -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding GO:0016021 integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.50108 BF_2 315.93 2.66 5249 642931184 XP_008196473.1 2454 9.4e-274 PREDICTED: mediator of RNA polymerase II transcription subunit 1 [Tribolium castaneum]>gi|270012110|gb|EFA08558.1| hypothetical protein TcasGA2_TC006213 [Tribolium castaneum] -- -- -- -- -- K15144 MED1 mediator of RNA polymerase II transcription subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15144 Q172G3 1280 5.3e-139 Mediator of RNA polymerase II transcription subunit 1 OS=Aedes aegypti GN=AAEL007402 PE=3 SV=1 PF04810//PF10744 Sec23/Sec24 zinc finger//Mediator of RNA polymerase II transcription subunit 1 GO:0006886//GO:0006888//GO:0006357 intracellular protein transport//ER to Golgi vesicle-mediated transport//regulation of transcription from RNA polymerase II promoter GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.5011 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50110 BF_2 148.32 1.30 5046 642935053 XP_008199922.1 1091 1.0e-115 PREDICTED: cerebellar degeneration-related protein 2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 347 7.8e-31 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF01025//PF02183//PF04977//PF16326//PF06156//PF10473//PF07926 GrpE//Homeobox associated leucine zipper//Septum formation initiator//ABC transporter C-terminal domain//Protein of unknown function (DUF972)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein GO:0006606//GO:0006355//GO:0006260//GO:0007049//GO:0006457 protein import into nucleus//regulation of transcription, DNA-templated//DNA replication//cell cycle//protein folding GO:0043565//GO:0042803//GO:0051087//GO:0000774//GO:0003700//GO:0003677//GO:0008134//GO:0045502 sequence-specific DNA binding//protein homodimerization activity//chaperone binding//adenyl-nucleotide exchange factor activity//transcription factor activity, sequence-specific DNA binding//DNA binding//transcription factor binding//dynein binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.50112 BF_2 25.00 3.42 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50114 BF_2 240.44 2.71 4003 91088329 XP_970397.1 411 5.7e-37 PREDICTED: geminin [Tribolium castaneum]>gi|270012171|gb|EFA08619.1| hypothetical protein TcasGA2_TC006282 [Tribolium castaneum] -- -- -- -- -- K10749 GMNN geminin http://www.genome.jp/dbget-bin/www_bget?ko:K10749 -- -- -- -- PF00833//PF07412//PF00714//PF06456 Ribosomal S17//Geminin//Interferon gamma//Arfaptin-like domain GO:0006275//GO:0007165//GO:0006412//GO:0006955//GO:0042254 regulation of DNA replication//signal transduction//translation//immune response//ribosome biogenesis GO:0019904//GO:0005133//GO:0003735 protein domain specific binding//interferon-gamma receptor binding//structural constituent of ribosome GO:0005622//GO:0005840//GO:0005576 intracellular//ribosome//extracellular region -- -- Cluster-8309.50116 BF_2 66.00 2.18 1553 478260764 ENN80437.1 252 6.1e-19 hypothetical protein YQE_03141, partial [Dendroctonus ponderosae] 642925806 XM_964316.3 202 3.55878e-99 PREDICTED: Tribolium castaneum glycine-rich cell wall structural protein (LOC657888), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50118 BF_2 112.14 0.56 8639 642937332 XP_008198790.1 3498 0.0e+00 PREDICTED: WD repeat-containing protein 96 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42260 843 4.1e-88 Glutamate receptor ionotropic, kainate 2 OS=Rattus norvegicus GN=Grik2 PE=1 SV=2 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0016020 membrane -- -- Cluster-8309.50119 BF_2 84.10 1.03 3718 646702401 KDR11613.1 2159 1.1e-239 Mothers against decapentaplegic-like protein 4 [Zootermopsis nevadensis] 552954715 KF307635.1 131 2.53898e-59 Pinctada fucata TGF beta signaling pathway factor (smad4) mRNA, complete cds K04501 SMAD4 mothers against decapentaplegic homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04501 Q9GKQ9 1075 2.2e-115 Mothers against decapentaplegic homolog 4 OS=Sus scrofa GN=SMAD4 PE=2 SV=1 PF03166//PF03165 MH2 domain//MH1 domain GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005622 intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.50120 BF_2 457.85 5.89 3537 270014279 EFA10727.1 1613 2.1e-176 cappuccino [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 781 2.6e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.50121 BF_2 27.25 0.38 3305 642933823 XP_008197408.1 1619 4.0e-177 PREDICTED: formin-2 [Tribolium castaneum] -- -- -- -- -- K02184 FMN2 formin 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02184 Q24120 776 9.2e-81 Protein cappuccino OS=Drosophila melanogaster GN=capu PE=1 SV=2 PF04513 Baculovirus polyhedron envelope protein, PEP, C terminus -- -- GO:0005198 structural molecule activity GO:0019028//GO:0019031 viral capsid//viral envelope KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.50122 BF_2 34.33 0.44 3572 91081013 XP_975219.1 1786 1.8e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 2.2e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.50123 BF_2 9.29 1.50 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50124 BF_2 67.80 4.33 942 642927700 XP_008196611.1 411 1.3e-37 PREDICTED: LOW QUALITY PROTEIN: oxidative stress-induced growth inhibitor 2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y236 229 7.0e-18 Oxidative stress-induced growth inhibitor 2 OS=Homo sapiens GN=OSGIN2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50125 BF_2 9.00 0.59 929 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50131 BF_2 323.55 1.67 8371 91080871 XP_972325.1 4869 0.0e+00 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.1e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF07645//PF00008//PF02257//PF06119 Calcium-binding EGF domain//EGF-like domain//RFX DNA-binding domain//Nidogen-like GO:0007160//GO:0006355 cell-matrix adhesion//regulation of transcription, DNA-templated GO:0003677//GO:0005509//GO:0005515 DNA binding//calcium ion binding//protein binding -- -- KOG1214 Nidogen and related basement membrane protein proteins Cluster-8309.50132 BF_2 7.00 0.44 955 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50136 BF_2 82.90 0.39 9135 91077944 XP_966624.1 1709 4.0e-187 PREDICTED: U3 small nucleolar RNA-associated protein 18 homolog [Tribolium castaneum]>gi|270001438|gb|EEZ97885.1| hypothetical protein TcasGA2_TC000267 [Tribolium castaneum] 642914704 XM_961439.3 98 1.38671e-40 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K14553 UTP18 U3 small nucleolar RNA-associated protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K14553 Q9V7P1 823 9.0e-86 U3 small nucleolar RNA-associated protein 18 homolog OS=Drosophila melanogaster GN=wcd PE=1 SV=1 PF00400//PF05434 WD domain, G-beta repeat//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2055 WD40 repeat protein Cluster-8309.50137 BF_2 12.98 0.37 1763 646721584 KDR22862.1 383 4.4e-34 Transcription initiation factor TFIID subunit 4 [Zootermopsis nevadensis] 642914704 XM_961439.3 98 2.63545e-41 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K03129 TAF4 transcription initiation factor TFIID subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03129 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50138 BF_2 21.00 2.53 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.50139 BF_2 156.89 1.19 5781 642914701 XP_008199886.1 2077 5.4e-230 PREDICTED: transcription initiation factor TFIID subunit 4 isoform X1 [Tribolium castaneum] 642914704 XM_961439.3 141 1.0937e-64 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K03129 TAF4 transcription initiation factor TFIID subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03129 O00268 702 6.1e-72 Transcription initiation factor TFIID subunit 4 OS=Homo sapiens GN=TAF4 PE=1 SV=2 PF05236//PF07531 Transcription initiation factor TFIID component TAF4 family//NHR1 homology to TAF GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005669//GO:0005667 transcription factor TFIID complex//transcription factor complex KOG2341 TATA box binding protein (TBP)-associated factor, RNA polymerase II Cluster-8309.5014 BF_2 8.29 0.47 1020 91079462 XP_966980.1 303 4.9e-25 PREDICTED: uncharacterized protein LOC655346 [Tribolium castaneum]>gi|270003455|gb|EEZ99902.1| hypothetical protein TcasGA2_TC002686 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50140 BF_2 21.00 2.53 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.50141 BF_2 117.04 0.56 9047 91077944 XP_966624.1 1709 4.0e-187 PREDICTED: U3 small nucleolar RNA-associated protein 18 homolog [Tribolium castaneum]>gi|270001438|gb|EEZ97885.1| hypothetical protein TcasGA2_TC000267 [Tribolium castaneum] 642914704 XM_961439.3 98 1.37329e-40 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K14553 UTP18 U3 small nucleolar RNA-associated protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K14553 Q9V7P1 823 8.9e-86 U3 small nucleolar RNA-associated protein 18 homolog OS=Drosophila melanogaster GN=wcd PE=1 SV=1 PF00400//PF05434 WD domain, G-beta repeat//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2055 WD40 repeat protein Cluster-8309.50143 BF_2 482.29 2.29 9083 91077944 XP_966624.1 1709 4.0e-187 PREDICTED: U3 small nucleolar RNA-associated protein 18 homolog [Tribolium castaneum]>gi|270001438|gb|EEZ97885.1| hypothetical protein TcasGA2_TC000267 [Tribolium castaneum] 642914704 XM_961439.3 98 1.37878e-40 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K14553 UTP18 U3 small nucleolar RNA-associated protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K14553 Q9V7P1 823 9.0e-86 U3 small nucleolar RNA-associated protein 18 homolog OS=Drosophila melanogaster GN=wcd PE=1 SV=1 PF00400//PF05434 WD domain, G-beta repeat//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG2055 WD40 repeat protein Cluster-8309.50145 BF_2 309.01 2.36 5770 642914701 XP_008199886.1 2077 5.4e-230 PREDICTED: transcription initiation factor TFIID subunit 4 isoform X1 [Tribolium castaneum] 642914704 XM_961439.3 141 1.0916e-64 PREDICTED: Tribolium castaneum transcription initiation factor TFIID subunit 4 (LOC654970), transcript variant X3, mRNA K03129 TAF4 transcription initiation factor TFIID subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K03129 O00268 702 6.1e-72 Transcription initiation factor TFIID subunit 4 OS=Homo sapiens GN=TAF4 PE=1 SV=2 PF07531//PF05236 NHR1 homology to TAF//Transcription initiation factor TFIID component TAF4 family GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005669//GO:0005667 transcription factor TFIID complex//transcription factor complex KOG2341 TATA box binding protein (TBP)-associated factor, RNA polymerase II Cluster-8309.50146 BF_2 48.10 5.17 676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.5015 BF_2 29.83 0.63 2278 642918256 XP_008191433.1 1117 4.4e-119 PREDICTED: low affinity cationic amino acid transporter 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395 7tm Chemosensory receptor GO:0050909 sensory perception of taste -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50150 BF_2 310.74 3.97 3563 642921224 XP_008192769.1 1938 4.4e-214 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921223 XM_008194547.1 369 0 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X1, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 677 3.0e-69 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF14604//PF00018//PF00023//PF03396//PF13606 Variant SH3 domain//SH3 domain//Ankyrin repeat//Poxvirus DNA-directed RNA polymerase, 35 kD subunit//Ankyrin repeat GO:0006144//GO:0006351//GO:0019083//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//viral transcription//pyrimidine nucleobase metabolic process GO:0005515//GO:0003899//GO:0003677 protein binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.50151 BF_2 68.17 0.54 5566 546680781 ERL90987.1 443 1.5e-40 hypothetical protein D910_08329 [Dendroctonus ponderosae] -- -- -- -- -- K18592 GGT1_5 gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18592 P07314 242 1.3e-18 Gamma-glutamyltranspeptidase 1 OS=Rattus norvegicus GN=Ggt1 PE=1 SV=4 PF01019 Gamma-glutamyltranspeptidase GO:0006749//GO:0006693//GO:0006691//GO:0019530 glutathione metabolic process//prostaglandin metabolic process//leukotriene metabolic process//taurine metabolic process GO:0003840 gamma-glutamyltransferase activity -- -- KOG2410 Gamma-glutamyltransferase Cluster-8309.50152 BF_2 3.17 0.35 668 801402421 XP_012061378.1 424 3.0e-39 PREDICTED: vacuolar protein sorting-associated protein 29 [Atta cephalotes] -- -- -- -- -- K18467 VPS29 vacuolar protein sorting-associated protein 29 http://www.genome.jp/dbget-bin/www_bget?ko:K18467 Q9QZ88 389 1.4e-36 Vacuolar protein sorting-associated protein 29 OS=Mus musculus GN=Vps29 PE=1 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3325 Membrane coat complex Retromer, subunit VPS29/PEP11 Cluster-8309.50155 BF_2 600.84 4.89 5431 665804096 XP_008550173.1 2041 7.6e-226 PREDICTED: potassium voltage-gated channel protein Shab isoform X2 [Microplitis demolitor] 795009898 XM_012008789.1 149 3.66794e-69 PREDICTED: Vollenhovia emeryi potassium voltage-gated channel protein Shab-like (LOC105560041), mRNA K04886 KCNB2 potassium voltage-gated channel Shab-related subfamily B member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04886 P17970 1859 4.0e-206 Potassium voltage-gated channel protein Shab OS=Drosophila melanogaster GN=Shab PE=1 SV=2 PF13374//PF02214//PF00520//PF01092 Tetratricopeptide repeat//BTB/POZ domain//Ion transport protein//Ribosomal protein S6e GO:0055085//GO:0006412//GO:0051260//GO:0006811//GO:0042254 transmembrane transport//translation//protein homooligomerization//ion transport//ribosome biogenesis GO:0005515//GO:0005216//GO:0003735 protein binding//ion channel activity//structural constituent of ribosome GO:0016020//GO:0005622//GO:0005840 membrane//intracellular//ribosome -- -- Cluster-8309.50156 BF_2 15.45 0.78 1114 642917930 XP_008200653.1 558 1.4e-54 PREDICTED: uncharacterized protein LOC103314985, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50158 BF_2 72.95 1.25 2721 642919246 XP_008191792.1 510 1.3e-48 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 312 4.8e-27 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50159 BF_2 448.65 8.65 2457 642919246 XP_008191792.1 900 6.9e-94 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 533 1.0e-52 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50161 BF_2 11.52 0.44 1384 642935247 XP_008197929.1 711 3.2e-72 PREDICTED: Down syndrome cell adhesion molecule isoform X2 [Tribolium castaneum] -- -- -- -- -- K06767 DSCAM Down syndrome cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06767 Q9VS29 373 2.1e-34 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50165 BF_2 3.00 0.66 477 733916798 XP_010720481.1 193 1.3e-12 PREDICTED: polyubiquitin-B, partial [Meleagris gallopavo] 70909910 AM049142.1 66 4.16551e-24 Carabus granulatus mRNA for ribosomal protein Ubq/L40e (ubiquitin/rpL40e gene) K04551 UBB ubiquitin B http://www.genome.jp/dbget-bin/www_bget?ko:K04551 P0CG65 179 2.2e-12 Polyubiquitin-B OS=Pan troglodytes GN=UBB PE=3 SV=1 PF00240 Ubiquitin family -- -- GO:0005515 protein binding -- -- KOG0001 Ubiquitin and ubiquitin-like proteins Cluster-8309.50168 BF_2 94.98 1.09 3938 642929450 XP_008195846.1 3584 0.0e+00 PREDICTED: serine/threonine-protein kinase D3 isoform X2 [Tribolium castaneum] 242010804 XM_002426104.1 343 3.79938e-177 Pediculus humanus corporis serine/threonine-protein kinase D1, putative, mRNA K06070 PKD protein kinase D http://www.genome.jp/dbget-bin/www_bget?ko:K06070 O94806 2295 8.0e-257 Serine/threonine-protein kinase D3 OS=Homo sapiens GN=PRKD3 PE=1 SV=1 PF06293//PF01155//PF00130//PF05445//PF00069//PF16866//PF07714//PF07649//PF00628 Lipopolysaccharide kinase (Kdo/WaaP) family//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//Poxvirus serine/threonine protein kinase//Protein kinase domain//PHD-finger//Protein tyrosine kinase//C1-like domain//PHD-finger GO:0006464//GO:0006468//GO:0055114//GO:0035556 cellular protein modification process//protein phosphorylation//oxidation-reduction process//intracellular signal transduction GO:0005524//GO:0005515//GO:0016151//GO:0016773//GO:0004672//GO:0047134 ATP binding//protein binding//nickel cation binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein-disulfide reductase activity GO:0016020 membrane KOG4236 Serine/threonine protein kinase PKC mu/PKD and related proteins Cluster-8309.50171 BF_2 23.77 0.39 2842 91078200 XP_968428.1 1053 1.5e-111 PREDICTED: m7GpppN-mRNA hydrolase [Tribolium castaneum]>gi|270001356|gb|EEZ97803.1| hypothetical protein TcasGA2_TC000167 [Tribolium castaneum] -- -- -- -- -- K12613 DCP2 mRNA-decapping enzyme subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12613 Q5REQ8 710 3.6e-73 m7GpppN-mRNA hydrolase OS=Pongo abelii GN=DCP2 PE=2 SV=1 PF05026//PF00293//PF15957//PF08273 Dcp2, box A domain//NUDIX domain//Commissureless//Zinc-binding domain of primase-helicase GO:0006269//GO:0006351//GO:0007411 DNA replication, synthesis of RNA primer//transcription, DNA-templated//axon guidance GO:0008270//GO:0016787//GO:0003896//GO:0004386//GO:0003723//GO:0030145 zinc ion binding//hydrolase activity//DNA primase activity//helicase activity//RNA binding//manganese ion binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2937 Decapping enzyme complex, predicted pyrophosphatase DCP2 Cluster-8309.50172 BF_2 1.00 0.65 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50173 BF_2 153.39 0.98 6861 478253900 ENN74192.1 2763 1.8e-309 hypothetical protein YQE_09165, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 2.05361e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1647 1.9e-181 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.50176 BF_2 265.00 22.58 778 226968618 YP_002808567.1 1066 1.2e-113 cytochrome c oxidase subunit III [Scylla paramamosain]>gi|225697854|gb|ACO07221.1| cytochrome c oxidase subunit III [Scylla paramamosain]>gi|403311093|gb|AFR34052.1| cytochrome c oxidase subunit III (mitochondrion) [Scylla paramamosain] 225697849 FJ827761.1 776 0 Scylla paramamosain mitochondrion, complete genome K02262 COX3 cytochrome c oxidase subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02262 B0FWD1 850 5.7e-90 Cytochrome c oxidase subunit 3 OS=Aedes aegypti GN=mt:CoIII PE=3 SV=1 -- -- GO:0006123//GO:0019646//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//aerobic electron transport chain//proton transport GO:0004129 cytochrome-c oxidase activity GO:0016021//GO:0045277//GO:0005739 integral component of membrane//respiratory chain complex IV//mitochondrion KOG4664 Cytochrome oxidase subunit III and related proteins Cluster-8309.50179 BF_2 671.23 5.42 5468 383847785 XP_003699533.1 2153 7.9e-239 PREDICTED: serine/threonine-protein phosphatase 5 isoform X1 [Megachile rotundata] 817223205 XM_012431486.1 202 1.27307e-98 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 1825 3.5e-202 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF13181//PF13174//PF13371//PF00515//PF00149//PF01553//PF13176//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Calcineurin-like phosphoesterase//Acyltransferase//Tetratricopeptide repeat//TPR repeat GO:0008152 metabolic process GO:0016746//GO:0005515//GO:0016787 transferase activity, transferring acyl groups//protein binding//hydrolase activity -- -- KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.50183 BF_2 285.94 10.76 1399 524901033 XP_005106931.1 651 3.0e-65 PREDICTED: ras-related protein Rab-1A [Aplysia californica] -- -- -- -- -- K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q05974 647 3.5e-66 Ras-related protein Rab-1A OS=Lymnaea stagnalis GN=RAB1A PE=2 SV=1 PF00071//PF00025//PF08477//PF03193//PF01926 Ras family//ADP-ribosylation factor family//Ras of Complex, Roc, domain of DAPkinase//Protein of unknown function, DUF258//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.50184 BF_2 22.40 0.43 2474 332027975 EGI68026.1 352 2.5e-30 Ras-related protein Rab-1A, partial [Acromyrmex echinatior] -- -- -- -- -- K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q39571 339 3.2e-30 GTP-binding protein YPTC1 OS=Chlamydomonas reinhardtii GN=YPTC1 PE=3 SV=1 PF08477//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.50185 BF_2 23.08 2.66 650 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50186 BF_2 419.50 10.45 1966 189242016 XP_001807518.1 1879 1.7e-207 PREDICTED: carboxypeptidase E-like [Tribolium castaneum] 37787288 AY214171.1 41 1.42961e-09 Paralichthys olivaceus carboxypeptidase H mRNA, complete cds K01294 CPE carboxypeptidase E http://www.genome.jp/dbget-bin/www_bget?ko:K01294 P37892 1035 5.1e-111 Carboxypeptidase E OS=Lophius americanus GN=cpe PE=2 SV=1 PF04952//PF00246 Succinylglutamate desuccinylase / Aspartoacylase family//Zinc carboxypeptidase GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016788//GO:0008270//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//metallocarboxypeptidase activity -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.50187 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50190 BF_2 56.19 0.64 3981 642923836 XP_008193900.1 2217 2.2e-246 PREDICTED: LOW QUALITY PROTEIN: DNA repair protein complementing XP-G cells homolog [Tribolium castaneum] -- -- -- -- -- K10846 ERCC5, XPG, RAD2 DNA excision repair protein ERCC-5 http://www.genome.jp/dbget-bin/www_bget?ko:K10846 P28715 623 6.1e-63 DNA repair protein complementing XP-G cells OS=Homo sapiens GN=ERCC5 PE=1 SV=3 PF00867//PF00752 XPG I-region//XPG N-terminal domain GO:0006281 DNA repair GO:0004518 nuclease activity -- -- KOG2520 5'-3' exonuclease Cluster-8309.50191 BF_2 36.63 0.97 1861 642928561 XP_008199958.1 1171 2.0e-125 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 805 2.2e-84 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067//PF02959 Cytochrome P450//HTLV Tax GO:0055114//GO:0045893 oxidation-reduction process//positive regulation of transcription, DNA-templated GO:0005506//GO:0016491//GO:0020037//GO:0005488//GO:0016705 iron ion binding//oxidoreductase activity//heme binding//binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.50197 BF_2 14.00 22.29 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50198 BF_2 25.27 0.41 2888 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50201 BF_2 214.00 23.38 670 91080149 XP_968815.1 364 2.7e-32 PREDICTED: uncharacterized protein LOC657254 [Tribolium castaneum]>gi|270006413|gb|EFA02861.1| odorant binding protein 17 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P54192 145 2.7e-08 General odorant-binding protein 19d OS=Drosophila melanogaster GN=Obp19d PE=2 SV=2 PF00039//PF01395 Fibronectin type I domain//PBP/GOBP family -- -- GO:0005549 odorant binding GO:0005576 extracellular region -- -- Cluster-8309.50202 BF_2 1302.80 8.60 6621 642930492 XP_008196426.1 2252 3.2e-250 PREDICTED: CLIP-associating protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K16578 CLASP1_2 CLIP-associating protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K16578 Q99JD4 867 5.2e-91 CLIP-associating protein 2 OS=Rattus norvegicus GN=Clasp2 PE=2 SV=1 PF02985//PF12844//PF01528 HEAT repeat//Helix-turn-helix domain//Herpesvirus glycoprotein M -- -- GO:0005515//GO:0043565 protein binding//sequence-specific DNA binding GO:0016020 membrane -- -- Cluster-8309.50203 BF_2 444.06 3.75 5237 642922255 XP_008193081.1 3052 0.0e+00 PREDICTED: sodium bicarbonate cotransporter 3 isoform X2 [Tribolium castaneum] 642922254 XM_008194859.1 405 0 PREDICTED: Tribolium castaneum sodium bicarbonate cotransporter 3 (LOC661759), transcript variant X4, mRNA -- -- -- -- Q8JZR6 1986 7.2e-221 Electroneutral sodium bicarbonate exchanger 1 OS=Mus musculus GN=Slc4a8 PE=2 SV=1 PF00955//PF07565 HCO3- transporter family//Band 3 cytoplasmic domain GO:0006820 anion transport GO:0008509 anion transmembrane transporter activity GO:0016021 integral component of membrane KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.50206 BF_2 49.31 0.55 4049 91090772 XP_969499.1 1511 1.6e-164 PREDICTED: rapamycin-insensitive companion of mTOR [Tribolium castaneum]>gi|270013969|gb|EFA10417.1| hypothetical protein TcasGA2_TC012657 [Tribolium castaneum] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 725 9.2e-75 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.50207 BF_2 4.00 1.10 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50209 BF_2 22.92 0.71 1630 91094501 XP_971498.1 793 1.2e-81 PREDICTED: translation initiation factor eIF-2B subunit alpha [Tribolium castaneum]>gi|270000750|gb|EEZ97197.1| hypothetical protein TcasGA2_TC004385 [Tribolium castaneum] 815821379 XM_012376515.1 71 2.48479e-26 PREDICTED: Linepithema humile translation initiation factor eIF-2B subunit alpha (LOC105677712), mRNA K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q0IIF2 560 5.1e-56 Translation initiation factor eIF-2B subunit alpha OS=Bos taurus GN=EIF2B1 PE=2 SV=1 PF01008 Initiation factor 2 subunit family GO:0044237 cellular metabolic process -- -- -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.5021 BF_2 5.00 1.14 470 602715618 XP_007468010.1 677 9.6e-69 PREDICTED: 60S ribosomal protein L23-like [Lipotes vexillifer] 40226377 BC010114.2 470 0 Homo sapiens ribosomal protein L23, mRNA (cDNA clone MGC:19760 IMAGE:3632936), complete cds K02894 RP-L23e, RPL23 large subunit ribosomal protein L23e http://www.genome.jp/dbget-bin/www_bget?ko:K02894 P62829 664 1.3e-68 60S ribosomal protein L23 OS=Homo sapiens GN=RPL23 PE=1 SV=1 PF00238 Ribosomal protein L14p/L23e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0901 60S ribosomal protein L14/L17/L23 Cluster-8309.50210 BF_2 148.54 6.78 1204 646700908 KDR10861.1 1083 2.0e-115 Translation initiation factor eIF-2B subunit alpha [Zootermopsis nevadensis] 815821379 XM_012376515.1 71 1.82114e-26 PREDICTED: Linepithema humile translation initiation factor eIF-2B subunit alpha (LOC105677712), mRNA K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q14232 819 3.5e-86 Translation initiation factor eIF-2B subunit alpha OS=Homo sapiens GN=EIF2B1 PE=1 SV=1 PF01008 Initiation factor 2 subunit family GO:0044237 cellular metabolic process -- -- -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.50211 BF_2 187.00 3.13 2786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0009405//GO:0019835 pathogenesis//cytolysis -- -- GO:0019867 outer membrane -- -- Cluster-8309.50214 BF_2 117.02 1.70 3171 546684811 ERL94393.1 1865 1.1e-205 hypothetical protein D910_11672, partial [Dendroctonus ponderosae] 195134144 XM_002011462.1 52 1.78103e-15 Drosophila mojavensis GI14008 (Dmoj\GI14008), mRNA -- -- -- -- Q9VY99 1021 3.4e-109 Cytosolic carboxypeptidase NnaD OS=Drosophila melanogaster GN=NnaD PE=2 SV=2 PF04928//PF00246//PF04952 Poly(A) polymerase central domain//Zinc carboxypeptidase//Succinylglutamate desuccinylase / Aspartoacylase family GO:0006508//GO:0043631//GO:0008152 proteolysis//RNA polyadenylation//metabolic process GO:0016788//GO:0008270//GO:0004652//GO:0004181 hydrolase activity, acting on ester bonds//zinc ion binding//polynucleotide adenylyltransferase activity//metallocarboxypeptidase activity -- -- KOG3641 Zinc carboxypeptidase Cluster-8309.50216 BF_2 194.97 5.79 1695 642913503 XP_008201041.1 1467 8.6e-160 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 Q91YJ2 811 4.1e-85 Sorting nexin-4 OS=Mus musculus GN=Snx4 PE=2 SV=1 PF00500//PF00787 L1 (late) protein//PX domain GO:0007154 cell communication GO:0035091//GO:0005198 phosphatidylinositol binding//structural molecule activity GO:0019028 viral capsid KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.50218 BF_2 54.77 1.26 2111 642913503 XP_008201041.1 1541 2.8e-168 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 A1A4L0 837 5.0e-88 Sorting nexin-4 OS=Bos taurus GN=SNX4 PE=2 SV=1 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.50224 BF_2 9.74 0.73 845 91089739 XP_975135.1 570 4.4e-56 PREDICTED: S-adenosylmethionine mitochondrial carrier protein homolog [Tribolium castaneum]>gi|270012648|gb|EFA09096.1| hypothetical protein TcasGA2_TC006818 [Tribolium castaneum] -- -- -- -- -- K15111 SLC25A26 solute carrier family 25 (mitochondrial S-adenosylmethionine transporter), member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K15111 Q9VBN7 347 1.3e-31 S-adenosylmethionine mitochondrial carrier protein homolog OS=Drosophila melanogaster GN=CG4743 PE=2 SV=2 PF02554//PF09515 Carbon starvation protein CstA//Thiamine transporter protein (Thia_YuaJ) GO:0009267//GO:0015888 cellular response to starvation//thiamine transport GO:0015234 thiamine transmembrane transporter activity GO:0016020//GO:0005886 membrane//plasma membrane KOG0768 Mitochondrial carrier protein PET8 Cluster-8309.50231 BF_2 163.33 1.17 6113 734625955 XP_010741096.1 446 7.6e-41 PREDICTED: uncharacterized protein LOC104928499 [Larimichthys crocea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8IYB9 395 2.6e-36 Zinc finger protein 595 OS=Homo sapiens GN=ZNF595 PE=2 SV=1 PF00096//PF13465//PF13912//PF06305 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Protein of unknown function (DUF1049) -- -- GO:0046872 metal ion binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.50232 BF_2 137.15 2.50 2578 91082913 XP_972525.1 874 7.5e-91 PREDICTED: sorting nexin-20 [Tribolium castaneum]>gi|270007065|gb|EFA03513.1| hypothetical protein TcasGA2_TC013515 [Tribolium castaneum] -- -- -- -- -- K01070 frmB, ESD, fghA S-formylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01070 Q9R0P3 549 1.5e-54 S-formylglutathione hydrolase OS=Mus musculus GN=Esd PE=1 SV=1 PF00787//PF10503 PX domain//Esterase PHB depolymerase -- -- GO:0035091 phosphatidylinositol binding GO:0005576 extracellular region KOG3101 Esterase D Cluster-8309.50233 BF_2 461.08 4.19 4887 642914939 XP_008190450.1 1788 1.5e-196 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K13983 MOV10L1 putative helicase MOV10L1 http://www.genome.jp/dbget-bin/www_bget?ko:K13983 Q1LXK4 952 5.3e-101 Putative helicase mov-10-B.1 OS=Danio rerio GN=mov10b.1 PE=2 SV=2 PF02562//PF01637//PF04851//PF00176//PF00580//PF05970//PF13361//PF00270//PF00437//PF00004 PhoH-like protein//Archaeal ATPase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain//UvrD/REP helicase N-terminal domain//PIF1-like helicase//UvrD-like helicase C-terminal domain//DEAD/DEAH box helicase//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0000723//GO:0006810//GO:0006281 telomere maintenance//transport//DNA repair GO:0003676//GO:0016787//GO:0003677//GO:0003678//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//DNA helicase activity//ATP binding GO:0005657 replication fork KOG1804 RNA helicase Cluster-8309.50236 BF_2 43.70 0.78 2641 270006959 EFA03407.1 1289 5.8e-139 hypothetical protein TcasGA2_TC013394 [Tribolium castaneum] -- -- -- -- -- K11248 SH3GLB endophilin-B http://www.genome.jp/dbget-bin/www_bget?ko:K11248 Q5ZIR1 753 3.4e-78 Endophilin-B1 OS=Gallus gallus GN=SH3GLB1 PE=2 SV=1 PF00018//PF14604//PF03114 SH3 domain//Variant SH3 domain//BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG3725 SH3 domain protein SH3GLB Cluster-8309.50240 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50245 BF_2 375.81 4.57 3728 270009986 EFA06434.1 1611 3.8e-176 hypothetical protein TcasGA2_TC009315 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2H0 324 2.7e-28 Disks large-associated protein 4 OS=Homo sapiens GN=DLGAP4 PE=1 SV=3 PF03359//PF01544//PF02653 Guanylate-kinase-associated protein (GKAP) protein//CorA-like Mg2+ transporter protein//Branched-chain amino acid transport system / permease component GO:0055085//GO:0023052//GO:0030001//GO:0006810 transmembrane transport//signaling//metal ion transport//transport GO:0046873//GO:0005215 metal ion transmembrane transporter activity//transporter activity GO:0016020 membrane KOG3971 SAP-90/PSD-95 associated protein-related protein (Vulcan) Cluster-8309.50247 BF_2 35.00 6.08 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50248 BF_2 169.84 2.36 3298 642911164 XP_008200608.1 2198 2.9e-244 PREDICTED: sodium/hydrogen exchanger 7 isoform X1 [Tribolium castaneum] 556959399 XM_005990356.1 38 1.12325e-07 PREDICTED: Latimeria chalumnae solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant X3, mRNA K12041 SLC9A6_7, NHE6_7 solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K12041 Q8BLV3 1283 1.5e-139 Sodium/hydrogen exchanger 7 OS=Mus musculus GN=Slc9a7 PE=2 SV=1 PF00999//PF11522 Sodium/hydrogen exchanger family//Yeast phosphatidylinositol-4-OH kinase Pik1 GO:0055085//GO:0006885//GO:0006812 transmembrane transport//regulation of pH//cation transport GO:0015299//GO:0016773 solute:proton antiporter activity//phosphotransferase activity, alcohol group as acceptor GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.50250 BF_2 446.06 6.34 3232 642918695 XP_008191541.1 1571 1.4e-171 PREDICTED: protein sprint isoform X3 [Tribolium castaneum]>gi|642918697|ref|XP_008191542.1| PREDICTED: protein sprint isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 643 2.4e-65 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.50254 BF_2 568.17 6.99 3685 642926212 XP_008194831.1 2213 5.9e-246 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926214|ref|XP_008194832.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926216|ref|XP_973431.2| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926218|ref|XP_008194833.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926220|ref|XP_008194834.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926222|ref|XP_008194835.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] 749752848 XM_011140486.1 61 2.05843e-20 PREDICTED: Harpegnathos saltator putative fatty acyl-CoA reductase CG5065 (LOC105182795), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1491 1.3e-163 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01073//PF01118//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0055114//GO:0006694//GO:0008209//GO:0008207//GO:0008210 oxidation-reduction process//steroid biosynthetic process//androgen metabolic process//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0080019//GO:0051287//GO:0016616//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.50255 BF_2 63.94 0.93 3172 189235122 XP_001811652.1 2006 5.1e-222 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 422 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1600 2.5e-176 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF04277//PF00856//PF01496//PF15048 Oxaloacetate decarboxylase, gamma chain//SET domain//V-type ATPase 116kDa subunit family//Organic solute transporter subunit beta protein GO:0015991//GO:0006560//GO:0006814//GO:0006090//GO:0071436//GO:0015992//GO:0006525//GO:0015721//GO:0006810 ATP hydrolysis coupled proton transport//proline metabolic process//sodium ion transport//pyruvate metabolic process//sodium ion export//proton transport//arginine metabolic process//bile acid and bile salt transport//transport GO:0015081//GO:0005215//GO:0046982//GO:0005515//GO:0015078//GO:0003682//GO:0008948 sodium ion transmembrane transporter activity//transporter activity//protein heterodimerization activity//protein binding//hydrogen ion transmembrane transporter activity//chromatin binding//oxaloacetate decarboxylase activity GO:0016020//GO:0033179//GO:0000785//GO:0005886 membrane//proton-transporting V-type ATPase, V0 domain//chromatin//plasma membrane KOG1079 Transcriptional repressor EZH1 Cluster-8309.50256 BF_2 155.36 1.46 4724 91083631 XP_970382.1 4149 0.0e+00 PREDICTED: NAD(P) transhydrogenase, mitochondrial [Tribolium castaneum]>gi|270006830|gb|EFA03278.1| hypothetical protein TcasGA2_TC013213 [Tribolium castaneum] 768393840 XM_011594299.1 171 1.87796e-81 PREDICTED: Aquila chrysaetos canadensis nicotinamide nucleotide transhydrogenase (NNT), mRNA K00323 NNT NAD(P) transhydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00323 P11024 3168 0.0e+00 NAD(P) transhydrogenase, mitochondrial OS=Bos taurus GN=NNT PE=1 SV=3 PF00236//PF07074//PF00107//PF02456//PF02233//PF00005//PF01752//PF02826//PF03188//PF00205 Glycoprotein hormone//Translocon-associated protein, gamma subunit (TRAP-gamma)//Zinc-binding dehydrogenase//Adenovirus IVa2 protein//NAD(P) transhydrogenase beta subunit//ABC transporter//Collagenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Eukaryotic cytochrome b561//Thiamine pyrophosphate enzyme, central domain GO:0006508//GO:0019083//GO:0007165//GO:0006613//GO:0046497//GO:0015992//GO:0006769//GO:0055114 proteolysis//viral transcription//signal transduction//cotranslational protein targeting to membrane//nicotinate nucleotide metabolic process//proton transport//nicotinamide metabolic process//oxidation-reduction process GO:0050661//GO:0051287//GO:0005179//GO:0030976//GO:0000287//GO:0005524//GO:0008750//GO:0016887//GO:0008270//GO:0004252 NADP binding//NAD binding//hormone activity//thiamine pyrophosphate binding//magnesium ion binding//ATP binding//NAD(P)+ transhydrogenase (AB-specific) activity//ATPase activity//zinc ion binding//serine-type endopeptidase activity GO:0030176//GO:0005784//GO:0005576//GO:0016021 integral component of endoplasmic reticulum membrane//Sec61 translocon complex//extracellular region//integral component of membrane -- -- Cluster-8309.50257 BF_2 184.10 3.70 2369 642915430 XP_008190612.1 1893 4.8e-209 PREDICTED: WD repeat-containing protein 75 [Tribolium castaneum]>gi|270004005|gb|EFA00453.1| hypothetical protein TcasGA2_TC003309 [Tribolium castaneum] -- -- -- -- -- K14552 NAN1, UTP17, WDR75 NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17) http://www.genome.jp/dbget-bin/www_bget?ko:K14552 Q6DFC6 757 1.1e-78 WD repeat-containing protein 75 OS=Xenopus laevis GN=wdr75 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1963 WD40 repeat protein Cluster-8309.50259 BF_2 8.69 1.09 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50262 BF_2 219.72 1.90 5126 91094587 XP_970350.1 3321 0.0e+00 PREDICTED: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Tribolium castaneum] 642939259 XM_965257.2 500 0 PREDICTED: Tribolium castaneum high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (LOC658906), mRNA K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 O70628 911 3.2e-96 High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A OS=Mus musculus GN=Pde9a PE=1 SV=1 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0007165//GO:0006144 signal transduction//purine nucleobase metabolic process GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.50263 BF_2 370.83 8.40 2134 642924770 XP_008194433.1 2238 4.3e-249 PREDICTED: netrin receptor UNC5C isoform X1 [Tribolium castaneum] -- -- -- -- -- K07521 UNC5 netrin receptor unc-5 http://www.genome.jp/dbget-bin/www_bget?ko:K07521 Q95TU8 714 9.2e-74 Netrin receptor unc-5 OS=Drosophila melanogaster GN=unc-5 PE=1 SV=1 PF11468//PF13895//PF01733//PF01632 Aromatic prenyltransferase Orf2//Immunoglobulin domain//Nucleoside transporter//Ribosomal protein L35 GO:0006810//GO:0006412//GO:0015858//GO:0042254 transport//translation//nucleoside transport//ribosome biogenesis GO:0005515//GO:0016740//GO:0005337//GO:0003735 protein binding//transferase activity//nucleoside transmembrane transporter activity//structural constituent of ribosome GO:0016021//GO:0005840//GO:0005622 integral component of membrane//ribosome//intracellular KOG1480 Netrin transmembrane receptor unc-5 Cluster-8309.50264 BF_2 261.94 23.73 749 478255161 ENN75390.1 547 1.8e-53 hypothetical protein YQE_07942, partial [Dendroctonus ponderosae] -- -- -- -- -- K15262 BCP1, BCCIP protein BCP1 http://www.genome.jp/dbget-bin/www_bget?ko:K15262 Q9VFR0 360 3.6e-33 Protein BCCIP homolog OS=Drosophila melanogaster GN=CG9286 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3034 Isoamyl acetate-hydrolyzing esterase and related enzymes Cluster-8309.50266 BF_2 378.87 1.23 13121 91081325 XP_970374.1 3636 0.0e+00 PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920734|ref|XP_008192539.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920736|ref|XP_008192541.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920738|ref|XP_008192542.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920740|ref|XP_008192543.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|642920742|ref|XP_008192544.1| PREDICTED: brain tumor protein [Tribolium castaneum]>gi|270006454|gb|EFA02902.1| brain tumor protein [Tribolium castaneum] 462431177 APGK01014745.1 798 0 Dendroctonus ponderosae Seq01014753, whole genome shotgun sequence K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 P34611 1666 2.3e-183 B-box type zinc finger protein ncl-1 OS=Caenorhabditis elegans GN=ncl-1 PE=2 SV=1 PF14634//PF00643//PF00097//PF06743//PF01436//PF03124//PF01017 zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger)//FAST kinase-like protein, subdomain 1//NHL repeat//EXS family//STAT protein, all-alpha domain GO:0006355//GO:0007165 regulation of transcription, DNA-templated//signal transduction GO:0046872//GO:0004672//GO:0003700//GO:0004871//GO:0008270//GO:0005515 metal ion binding//protein kinase activity//transcription factor activity, sequence-specific DNA binding//signal transducer activity//zinc ion binding//protein binding GO:0005622//GO:0005667//GO:0016021 intracellular//transcription factor complex//integral component of membrane KOG2177 Predicted E3 ubiquitin ligase Cluster-8309.50268 BF_2 59.07 0.49 5340 769848297 XP_011635512.1 1496 1.2e-162 PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus]>gi|769848299|ref|XP_011635513.1| PREDICTED: developmentally-regulated GTP-binding protein 2 [Pogonomyrmex barbatus] 572314861 XM_006623032.1 428 0 PREDICTED: Apis dorsata developmentally-regulated GTP-binding protein 2-like (LOC102680357), transcript variant X1, mRNA K06944 K06944 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06944 P55039 1333 3.8e-145 Developmentally-regulated GTP-binding protein 2 OS=Homo sapiens GN=DRG2 PE=1 SV=1 PF03006//PF02421//PF01926//PF03193//PF00176 Haemolysin-III related//Ferrous iron transport protein B//50S ribosome-binding GTPase//Protein of unknown function, DUF258//SNF2 family N-terminal domain GO:0015684 ferrous iron transport GO:0003924//GO:0005524//GO:0005525//GO:0015093 GTPase activity//ATP binding//GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane KOG1486 GTP-binding protein DRG2 (ODN superfamily) Cluster-8309.50269 BF_2 12.99 0.57 1245 642913824 XP_008201175.1 211 2.8e-14 PREDICTED: microtubule-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05296 Taste receptor protein (TAS2R) GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50272 BF_2 0.61 0.38 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50273 BF_2 395.37 3.10 5625 642937978 XP_008199153.1 3018 0.0e+00 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X5 [Tribolium castaneum] 807058312 KM232914.1 81 2.40302e-31 Petromyzon marinus ABCA2 mRNA, partial cds K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q8R420 1715 2.0e-189 ATP-binding cassette sub-family A member 3 OS=Mus musculus GN=Abca3 PE=2 SV=3 PF13304//PF06414//PF11080//PF03193//PF04310//PF00005//PF00448 AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//Protein of unknown function (DUF2622)//Protein of unknown function, DUF258//MukB N-terminal//ABC transporter//SRP54-type protein, GTPase domain GO:0006614//GO:0007059//GO:0051252//GO:0030261 SRP-dependent cotranslational protein targeting to membrane//chromosome segregation//regulation of RNA metabolic process//chromosome condensation GO:0003677//GO:0005524//GO:0003924//GO:0004521//GO:0016887//GO:0016301//GO:0005525 DNA binding//ATP binding//GTPase activity//endoribonuclease activity//ATPase activity//kinase activity//GTP binding GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.50274 BF_2 35.15 0.59 2792 642919713 XP_008192033.1 1789 6.5e-197 PREDICTED: ectonucleoside triphosphate diphosphohydrolase 5 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01511 ENTPD5_6 ectonucleoside triphosphate diphosphohydrolase 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K01511 E1BPW0 710 3.5e-73 Ectonucleoside triphosphate diphosphohydrolase 5 OS=Bos taurus GN=ENTPD5 PE=3 SV=1 PF01150 GDA1/CD39 (nucleoside phosphatase) family -- -- GO:0016787 hydrolase activity -- -- KOG1385 Nucleoside phosphatase Cluster-8309.50279 BF_2 470.92 7.49 2918 189238125 XP_001814215.1 3173 0.0e+00 PREDICTED: phagocyte signaling-impaired protein [Tribolium castaneum]>gi|270008817|gb|EFA05265.1| hypothetical protein TcasGA2_TC015420 [Tribolium castaneum] 462295253 APGK01052815.1 38 9.92396e-08 Dendroctonus ponderosae Seq01052825, whole genome shotgun sequence K17973 NAA25, MDM20 N-terminal acetyltransferase B complex non-catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17973 Q9VDQ7 1583 2.2e-174 Phagocyte signaling-impaired protein OS=Drosophila melanogaster GN=psidin PE=2 SV=1 PF14863//PF13414 Alkyl sulfatase dimerisation//TPR repeat -- -- GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- KOG2053 Mitochondrial inheritance and actin cytoskeleton organization protein Cluster-8309.50282 BF_2 33.40 0.87 1896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845 Spore germination protein GO:0009847 spore germination -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50283 BF_2 35.28 1.93 1051 189236433 XP_972706.2 827 8.7e-86 PREDICTED: nuclear transcription factor Y subunit alpha isoform X1 [Tribolium castaneum]>gi|270005402|gb|EFA01850.1| hypothetical protein TcasGA2_TC007453 [Tribolium castaneum] 642919803 XM_967613.3 141 1.93731e-65 PREDICTED: Tribolium castaneum nuclear transcription factor Y subunit alpha (LOC661458), transcript variant X1, mRNA K08064 NFYA nuclear transcription factor Y, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08064 P23511 325 5.8e-29 Nuclear transcription factor Y subunit alpha OS=Homo sapiens GN=NFYA PE=1 SV=2 PF11525//PF02045//PF00737//PF09606 Copper resistance protein K//CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B//Photosystem II 10 kDa phosphoprotein//ARC105 or Med15 subunit of Mediator complex non-fungal GO:0006355//GO:0006357//GO:0050821//GO:0015979 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//protein stabilization//photosynthesis GO:0046872//GO:0003700//GO:0042301//GO:0001104 metal ion binding//transcription factor activity, sequence-specific DNA binding//phosphate ion binding//RNA polymerase II transcription cofactor activity GO:0009523//GO:0016020//GO:0005667//GO:0016592 photosystem II//membrane//transcription factor complex//mediator complex KOG1561 CCAAT-binding factor, subunit B (HAP2) Cluster-8309.50284 BF_2 5.00 1.58 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50285 BF_2 18554.29 549.37 1700 578359006 AHI15746.1 1712 3.4e-188 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359005 KJ186848.1 1126 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-1) mRNA, complete cds -- -- -- -- O85465 625 1.5e-63 Endoglucanase 5A OS=Bacillus agaradhaerens GN=cel5A PE=1 SV=1 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.50289 BF_2 7.82 0.48 963 642916451 XP_008191033.1 241 7.1e-18 PREDICTED: transmembrane and coiled-coil domains protein 2 isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50292 BF_2 1334.52 12.45 4770 332377021 AEE63650.1 2446 7.3e-273 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01303 APEH acylaminoacyl-peptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01303 P13676 1008 1.7e-107 Acylamino-acid-releasing enzyme OS=Rattus norvegicus GN=Apeh PE=1 SV=1 PF00326//PF00769//PF07859//PF02129 Prolyl oligopeptidase family//Ezrin/radixin/moesin family//alpha/beta hydrolase fold//X-Pro dipeptidyl-peptidase (S15 family) GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008092//GO:0016787//GO:0008236 cytoskeletal protein binding//hydrolase activity//serine-type peptidase activity GO:0019898//GO:0005737 extrinsic component of membrane//cytoplasm KOG2010 Double stranded RNA binding protein Cluster-8309.50295 BF_2 29.00 36.67 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50296 BF_2 24.00 0.69 1751 391339726 XP_003744198.1 1607 5.2e-176 PREDICTED: retinal dehydrogenase 1-like [Metaseiulus occidentalis] -- -- -- -- -- K07249 E1.2.1.36 retinal dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K07249 Q8MI17 1525 6.9e-168 Retinal dehydrogenase 1 OS=Oryctolagus cuniculus GN=ALDH1A1 PE=2 SV=1 PF05893//PF00171 Acyl-CoA reductase (LuxC)//Aldehyde dehydrogenase family GO:0008218//GO:0055114//GO:0006118//GO:0008152 bioluminescence//oxidation-reduction process//obsolete electron transport//metabolic process GO:0016491//GO:0003995 oxidoreductase activity//acyl-CoA dehydrogenase activity -- -- KOG2450 Aldehyde dehydrogenase Cluster-8309.50297 BF_2 103.65 1.37 3444 642927943 XP_008195456.1 771 8.9e-79 PREDICTED: tetratricopeptide repeat protein 37 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DFB8 283 1.4e-23 Tetratricopeptide repeat protein 37 OS=Xenopus laevis GN=ttc37 PE=2 SV=1 PF13414//PF13174//PF13176//PF16045//PF13374//PF00515//PF13181 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//LisH//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50298 BF_2 102.00 14.23 587 546683525 ERL93327.1 440 3.6e-41 hypothetical protein D910_10621 [Dendroctonus ponderosae] 572257679 XM_006607174.1 44 8.80252e-12 PREDICTED: Apis dorsata PAXIP1-associated glutamate-rich protein 1-like (LOC102673490), mRNA K14973 PA1 PAXIP1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14973 Q9BTK6 134 4.5e-07 PAXIP1-associated glutamate-rich protein 1 OS=Homo sapiens GN=PAGR1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50300 BF_2 31.24 0.79 1951 642940167 XP_008194639.1 623 7.3e-62 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXM1 253 2.4e-20 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens GN=LRIG3 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.50302 BF_2 134.00 2.53 2506 642926809 XP_008195022.1 149 8.6e-07 PREDICTED: zinc finger protein 64 homolog, isoforms 3 and 4-like [Tribolium castaneum]>gi|270009173|gb|EFA05621.1| hypothetical protein TcasGA2_TC015829 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF10588 Zinc-finger associated domain (zf-AD)//NADH-ubiquinone oxidoreductase-G iron-sulfur binding region GO:0055114 oxidation-reduction process GO:0016491//GO:0008270 oxidoreductase activity//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.50303 BF_2 49.18 0.48 4591 642924939 XP_008194106.1 1397 3.0e-151 PREDICTED: uncharacterized protein LOC100142197 isoform X2 [Tribolium castaneum] 642924938 XM_008195884.1 157 1.10597e-73 PREDICTED: Tribolium castaneum uncharacterized LOC100142197 (LOC100142197), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50310 BF_2 60.00 2.84 1172 642933823 XP_008197408.1 189 9.2e-12 PREDICTED: formin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50315 BF_2 23.83 1.19 1122 861599125 KMQ83546.1 1141 3.6e-122 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q53H47 125 9.6e-06 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 PF00292//PF01498//PF09749//PF01047//PF02796//PF04218 'Paired box' domain//Transposase//Uncharacterised conserved protein//MarR family//Helix-turn-helix domain of resolvase//CENP-B N-terminal DNA-binding domain GO:0006313//GO:0015074//GO:0034477//GO:0006355//GO:0006310 transposition, DNA-mediated//DNA integration//U6 snRNA 3'-end processing//regulation of transcription, DNA-templated//DNA recombination GO:0000150//GO:0003677//GO:0003700//GO:0004518 recombinase activity//DNA binding//transcription factor activity, sequence-specific DNA binding//nuclease activity GO:0005667 transcription factor complex -- -- Cluster-8309.50318 BF_2 68.71 0.70 4404 795018312 XP_011859165.1 573 1.0e-55 PREDICTED: uncharacterized protein LOC105556682 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50321 BF_2 68.00 1.79 1879 270004788 EFA01236.1 980 2.8e-103 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1XG89 400 2.1e-37 Putative ATP-dependent RNA helicase TDRD12 OS=Bombyx mori GN=TDRD12 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50323 BF_2 51.54 0.60 3873 270004788 EFA01236.1 887 3.5e-92 female sterile Yb [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1XG89 287 5.4e-24 Putative ATP-dependent RNA helicase TDRD12 OS=Bombyx mori GN=TDRD12 PE=1 SV=2 PF00270 DEAD/DEAH box helicase -- -- GO:0005524//GO:0003676 ATP binding//nucleic acid binding -- -- -- -- Cluster-8309.50327 BF_2 236.65 1.01 10054 91076250 XP_966964.1 1806 2.5e-198 PREDICTED: testican-2 [Tribolium castaneum] 642912114 XM_961871.3 78 2.00316e-29 PREDICTED: Tribolium castaneum testican-2 (LOC655329), mRNA -- -- -- -- Q9ER58 343 4.5e-30 Testican-2 OS=Mus musculus GN=Spock2 PE=2 SV=1 PF07648//PF13833//PF00050//PF10591//PF00036//PF15009 Kazal-type serine protease inhibitor domain//EF-hand domain pair//Kazal-type serine protease inhibitor domain//Secreted protein acidic and rich in cysteine Ca binding region//EF hand//Transmembrane protein 173 GO:0032481//GO:0002218//GO:0007165 positive regulation of type I interferon production//activation of innate immune response//signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG3555 Ca2+-binding proteoglycan Testican Cluster-8309.50330 BF_2 134.28 2.78 2305 642918756 XP_008191570.1 1365 7.8e-148 PREDICTED: thymidylate synthase-like [Tribolium castaneum]>gi|270005647|gb|EFA02095.1| hypothetical protein TcasGA2_TC007732 [Tribolium castaneum] 674038954 XM_008826954.1 103 5.75244e-44 PREDICTED: Nannospalax galili thymidylate synthetase (Tyms), mRNA K00560 thyA, TYMS thymidylate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00560 P04818 1141 3.0e-123 Thymidylate synthase OS=Homo sapiens GN=TYMS PE=1 SV=3 PF02949//PF00303//PF06385 7tm Odorant receptor//Thymidylate synthase//Baculovirus LEF-11 protein GO:0019058//GO:0006231//GO:0007187//GO:0032259//GO:0006206//GO:0007608//GO:0006235//GO:0006355 viral life cycle//dTMP biosynthetic process//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//methylation//pyrimidine nucleobase metabolic process//sensory perception of smell//dTTP biosynthetic process//regulation of transcription, DNA-templated GO:0005549//GO:0004984//GO:0004799 odorant binding//olfactory receptor activity//thymidylate synthase activity GO:0016020 membrane KOG0673 Thymidylate synthase Cluster-8309.50333 BF_2 421.24 2.71 6793 91077932 XP_974190.1 2842 0.0e+00 PREDICTED: conserved oligomeric Golgi complex subunit 7 [Tribolium castaneum] 820862785 XM_003697932.2 121 1.68694e-53 PREDICTED: Apis florea U4/U6 small nuclear ribonucleoprotein Prp4 (LOC100870360), mRNA K12662 PRPF4, PRP4 U4/U6 small nuclear ribonucleoprotein PRP4 http://www.genome.jp/dbget-bin/www_bget?ko:K12662 Q3MHE2 1614 1.3e-177 U4/U6 small nuclear ribonucleoprotein Prp4 OS=Bos taurus GN=PRPF4 PE=2 SV=1 PF10191//PF10392//PF02468//PF00400 Golgi complex component 7 (COG7)//Golgi transport complex subunit 5//Photosystem II reaction centre N protein (psbN)//WD domain, G-beta repeat GO:0006886//GO:0006891//GO:0015979 intracellular protein transport//intra-Golgi vesicle-mediated transport//photosynthesis GO:0005515 protein binding GO:0009523//GO:0009539//GO:0017119//GO:0016020 photosystem II//photosystem II reaction center//Golgi transport complex//membrane KOG0272 U4/U6 small nuclear ribonucleoprotein Prp4 (contains WD40 repeats) Cluster-8309.50338 BF_2 63.93 0.50 5613 642928360 XP_972133.2 2245 1.7e-249 PREDICTED: ATP-binding cassette sub-family B member 8, mitochondrial isoform X1 [Tribolium castaneum] 768408887 XM_011551471.1 79 3.10182e-30 PREDICTED: Plutella xylostella igLON family member 5-like (LOC105381682), mRNA K05655 ABCB8 ATP-binding cassette, subfamily B (MDR/TAP), member 8 http://www.genome.jp/dbget-bin/www_bget?ko:K05655 B2GUP8 1544 1.4e-169 ATP-binding cassette sub-family B member 8, mitochondrial OS=Xenopus tropicalis GN=abcb8 PE=2 SV=1 PF06472//PF12814//PF01583//PF13304//PF00664//PF13895//PF03193//PF00005//PF06414 ABC transporter transmembrane region 2//Meiotic cell cortex C-terminal pleckstrin homology//Adenylylsulphate kinase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Immunoglobulin domain//Protein of unknown function, DUF258//ABC transporter//Zeta toxin GO:0006810//GO:0055085//GO:0006144//GO:0000103//GO:0032065 transport//transmembrane transport//purine nucleobase metabolic process//sulfate assimilation//cortical protein anchoring GO:0003924//GO:0005524//GO:0042626//GO:0016887//GO:0016301//GO:0005543//GO:0004020//GO:0005515//GO:0005525 GTPase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances//ATPase activity//kinase activity//phospholipid binding//adenylylsulfate kinase activity//protein binding//GTP binding GO:0016021//GO:0005938 integral component of membrane//cell cortex KOG0058 Peptide exporter, ABC superfamily Cluster-8309.50339 BF_2 168.74 0.92 7953 751224154 XP_011165403.1 884 1.6e-91 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07180//PF01825 Protein of unknown function (DUF1401)//GPCR proteolysis site, GPS, motif GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50340 BF_2 321.95 1.86 7510 751224154 XP_011165403.1 1440 5.1e-156 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50341 BF_2 141.24 0.75 8155 751224154 XP_011165403.1 1304 3.3e-140 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50342 BF_2 198.41 1.10 7846 751224154 XP_011165403.1 1312 3.7e-141 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01825//PF07180 GPCR proteolysis site, GPS, motif//Protein of unknown function (DUF1401) GO:0006351 transcription, DNA-templated -- -- GO:0016020 membrane -- -- Cluster-8309.50344 BF_2 225.00 7.08 1617 642933692 XP_008197523.1 1004 4.0e-106 PREDICTED: ankyrin repeat domain-containing protein 6 [Tribolium castaneum]>gi|270012614|gb|EFA09062.1| hypothetical protein TcasGA2_TC006777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y2G4 484 3.3e-47 Ankyrin repeat domain-containing protein 6 OS=Homo sapiens GN=ANKRD6 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50345 BF_2 247.00 9.71 1351 61652776 AAX47960.1 737 3.0e-75 prophenoloxidase activating factor serine proteinase [Scylla serrata] 61652775 AY946200.1 252 4.9481e-127 Scylla serrata prophenoloxidase activating factor serine proteinase (PPAF-SP) mRNA, complete cds -- -- -- -- Q7RTY7 459 2.2e-44 Ovochymase-1 OS=Homo sapiens GN=OVCH1 PE=2 SV=2 PF00089//PF16622 Trypsin//zinc-finger C2H2-type GO:0006508 proteolysis GO:0004252//GO:0046872 serine-type endopeptidase activity//metal ion binding -- -- -- -- Cluster-8309.50346 BF_2 10.00 1.02 699 -- -- -- -- -- 333103092 JF715397.1 177 1.23143e-85 Scylla paramamosain clone SP13 microsatellite sequence -- -- -- -- -- -- -- -- PF05434//PF12409 TMEM9//P5-type ATPase cation transporter GO:0006812 cation transport GO:0016887 ATPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50347 BF_2 24.00 0.50 2284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50352 BF_2 115.10 1.55 3386 478254798 ENN75034.1 2058 5.1e-228 hypothetical protein YQE_08349, partial [Dendroctonus ponderosae] 642926307 XM_008196649.1 227 9.94294e-113 PREDICTED: Tribolium castaneum band 4.1-like protein 5 (LOC103313424), mRNA -- -- -- -- Q5FVG2 1138 1.0e-122 Band 4.1-like protein 5 OS=Rattus norvegicus GN=Epb41l5 PE=2 SV=2 PF00887//PF00403 Acyl CoA binding protein//Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872//GO:0000062 metal ion binding//fatty-acyl-CoA binding -- -- KOG3530 FERM domain protein EHM2 Cluster-8309.50353 BF_2 58.00 1.54 1858 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50354 BF_2 18.35 0.34 2534 607361054 EZA55356.1 530 5.7e-51 Putative nuclease HARBI1, partial [Cerapachys biroi] -- -- -- -- -- -- -- -- -- Q6AZB8 284 7.9e-24 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF03213//PF01609 Poxvirus P35 protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding GO:0019031 viral envelope -- -- Cluster-8309.50357 BF_2 136.02 0.70 8446 270015299 EFA11747.1 1770 3.1e-194 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 589 1.1e-58 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF00041//PF13895//PF16656 Fibronectin type III domain//Immunoglobulin domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.50358 BF_2 3.00 1.41 374 642929839 XP_008195996.1 298 6.7e-25 PREDICTED: uncharacterized protein LOC103313727 [Tribolium castaneum]>gi|270009520|gb|EFA05968.1| hypothetical protein TcasGA2_TC008789 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50362 BF_2 150.22 0.95 6933 642940100 XP_970097.2 1204 1.1e-128 PREDICTED: excitatory amino acid transporter isoform X2 [Tribolium castaneum] -- -- -- -- -- K05612 SLC1A1, EAAT3 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05612 Q10901 602 2.9e-60 Excitatory amino acid transporter OS=Caenorhabditis elegans GN=glt-1 PE=1 SV=2 PF01585//PF00375 G-patch domain//Sodium:dicarboxylate symporter family GO:0006820//GO:0006812//GO:0006835 anion transport//cation transport//dicarboxylic acid transport GO:0017153//GO:0003676 sodium:dicarboxylate symporter activity//nucleic acid binding GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.50367 BF_2 19.43 0.33 2750 546684608 ERL94225.1 1767 2.3e-194 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 747 1.8e-77 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.50373 BF_2 16.30 0.32 2425 546681787 ERL91813.1 401 5.0e-36 hypothetical protein D910_09138 [Dendroctonus ponderosae] -- -- -- -- -- K13753 SLC24A5, NCKX5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13753 Q71RS6 244 3.3e-19 Sodium/potassium/calcium exchanger 5 OS=Homo sapiens GN=SLC24A5 PE=1 SV=1 PF01699 Sodium/calcium exchanger protein GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG1307 K+-dependent Ca2+/Na+ exchanger NCKX1 and related proteins Cluster-8309.50374 BF_2 21.00 2.55 632 478252081 ENN72512.1 224 4.3e-16 hypothetical protein YQE_10853, partial [Dendroctonus ponderosae]>gi|546685597|gb|ERL95084.1| hypothetical protein D910_12354, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12106 Colicin C terminal ribonuclease domain GO:0051252 regulation of RNA metabolic process GO:0004540 ribonuclease activity -- -- -- -- Cluster-8309.50375 BF_2 73.00 2.13 1722 91084303 XP_971911.1 1275 1.6e-137 PREDICTED: T-box transcription factor TBX1-A [Tribolium castaneum]>gi|270009267|gb|EFA05715.1| optomotor blind related gene 1 protein [Tribolium castaneum] 884973126 XM_010885314.2 48 1.60425e-13 PREDICTED: Esox lucius T-box 20 (tbx20), transcript variant X4, mRNA K10175 TBX1 T-box protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10175 Q8AX98 849 1.6e-89 T-box transcription factor TBX1-A OS=Xenopus laevis GN=tbx1-a PE=1 SV=1 PF00907 T-box GO:0006355//GO:0006351 regulation of transcription, DNA-templated//transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.50376 BF_2 175.57 1.56 5000 91085385 XP_966386.1 455 5.6e-42 PREDICTED: arginine/serine-rich coiled-coil protein 2 [Tribolium castaneum]>gi|270009149|gb|EFA05597.1| hypothetical protein TcasGA2_TC015801 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XHJ5 200 8.6e-14 Arginine/serine-rich coiled-coil protein 2 OS=Xenopus tropicalis GN=rsrc2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50380 BF_2 1113.74 12.73 3946 270002078 EEZ98525.1 246 7.7e-18 hypothetical protein TcasGA2_TC001029 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50384 BF_2 85.79 0.86 4475 478255961 ENN76162.1 1692 1.8e-185 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 Q8WY07 1081 5.4e-116 Cationic amino acid transporter 3 OS=Homo sapiens GN=SLC7A3 PE=1 SV=1 PF13520//PF15020//PF00324 Amino acid permease//Cation channel sperm-associated protein subunit delta//Amino acid permease GO:0006865//GO:0003333//GO:0055085//GO:0006810 amino acid transport//amino acid transmembrane transport//transmembrane transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0036128//GO:0016020 CatSper complex//membrane -- -- Cluster-8309.50386 BF_2 23.44 1.24 1075 642920711 XP_008192531.1 633 2.8e-63 PREDICTED: uncharacterized protein LOC103312793 isoform X1 [Tribolium castaneum]>gi|270006095|gb|EFA02543.1| hypothetical protein TcasGA2_TC008248 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50389 BF_2 406.00 2.98 5978 642920612 XP_008192488.1 1042 5.8e-110 PREDICTED: uncharacterized protein LOC103312782 [Tribolium castaneum]>gi|270006183|gb|EFA02631.1| hypothetical protein TcasGA2_TC008351 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01127 Succinate dehydrogenase/Fumarate reductase transmembrane subunit -- -- GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors -- -- -- -- Cluster-8309.50392 BF_2 199.98 8.43 1279 91082137 XP_966595.1 1464 1.4e-159 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 172 1.38598e-82 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1193 1.6e-129 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.50394 BF_2 30.87 0.77 1970 332373656 AEE61969.1 1637 1.9e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 387 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 A9JRC7 1586 6.5e-175 Serine/threonine-protein phosphatase 4 catalytic subunit B OS=Danio rerio GN=ppp4cb PE=2 SV=1 PF00149//PF01429 Calcineurin-like phosphoesterase//Methyl-CpG binding domain -- -- GO:0016787//GO:0003677 hydrolase activity//DNA binding GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.50395 BF_2 186.82 1.81 4608 642918982 XP_008191684.1 4714 0.0e+00 PREDICTED: probable phospholipid-transporting ATPase IA isoform X5 [Tribolium castaneum] 170040348 XM_001847913.1 155 1.436e-72 Culex quinquefasciatus phospholipid-transporting ATPase 1, mRNA K14802 DRS2, ATP8A phospholipid-transporting ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K14802 Q9Y2Q0 3152 0.0e+00 Phospholipid-transporting ATPase IA OS=Homo sapiens GN=ATP8A1 PE=1 SV=1 PF00122 E1-E2 ATPase -- -- GO:0046872//GO:0000166 metal ion binding//nucleotide binding -- -- KOG0206 P-type ATPase Cluster-8309.50396 BF_2 802.51 3.29 10489 642918082 XP_008193932.1 1793 8.4e-197 PREDICTED: protein disulfide-isomerase TMX3 [Tribolium castaneum] 795019206 XM_012004108.1 296 1.36347e-150 PREDICTED: Vollenhovia emeryi uncharacterized LOC105556990 (LOC105556990), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q9VPF8 987 1.0e-104 Transmembrane protein 104 homolog OS=Drosophila melanogaster GN=CG5262 PE=2 SV=2 PF00085//PF00400//PF01428//PF01984//PF03222//PF00659//PF01216//PF02073//PF00578 Thioredoxin//WD domain, G-beta repeat//AN1-like Zinc finger//Double-stranded DNA-binding domain//Tryptophan/tyrosine permease family//POLO box duplicated region//Calsequestrin//Thermophilic metalloprotease (M29)//AhpC/TSA family GO:0045454//GO:0055114//GO:0006508//GO:0003333 cell redox homeostasis//oxidation-reduction process//proteolysis//amino acid transmembrane transport GO:0005515//GO:0016491//GO:0003677//GO:0016209//GO:0004177//GO:0008270//GO:0005509 protein binding//oxidoreductase activity//DNA binding//antioxidant activity//aminopeptidase activity//zinc ion binding//calcium ion binding -- -- KOG4277 Uncharacterized conserved protein, contains thioredoxin domain Cluster-8309.50399 BF_2 48.38 2.44 1117 270011245 EFA07693.1 507 1.2e-48 hypothetical protein TcasGA2_TC030782, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X3B2 187 6.2e-13 Adipocyte plasma membrane-associated protein OS=Salmo salar GN=apmap PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG1520 Predicted alkaloid synthase/Surface mucin Hemomucin Cluster-8309.5040 BF_2 8.00 0.34 1258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50400 BF_2 95.67 5.11 1070 91092208 XP_969730.1 1137 1.0e-121 PREDICTED: protein unc-50 homolog [Tribolium castaneum]>gi|270014482|gb|EFA10930.1| hypothetical protein TcasGA2_TC001757 [Tribolium castaneum] 602644740 XM_007428757.1 50 7.61834e-15 PREDICTED: Python bivittatus unc-50 homolog (C. elegans) (UNC50), transcript variant X5, mRNA -- -- -- -- Q9VHN5 860 5.4e-91 Protein unc-50 homolog OS=Drosophila melanogaster GN=CG9773 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3012 Uncharacterized conserved protein Cluster-8309.50401 BF_2 3.00 0.57 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00879//PF04446 Defensin propeptide//tRNAHis guanylyltransferase GO:0006400//GO:0006952 tRNA modification//defense response GO:0000287//GO:0008193 magnesium ion binding//tRNA guanylyltransferase activity -- -- -- -- Cluster-8309.50402 BF_2 44.19 0.38 5097 768426896 XP_011554510.1 578 3.1e-56 PREDICTED: uncharacterized protein LOC105385776, partial [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q7M3K2 212 3.6e-15 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485//PF01979 THAP domain//Amidohydrolase family -- -- GO:0016787//GO:0003676 hydrolase activity//nucleic acid binding -- -- -- -- Cluster-8309.50404 BF_2 3.00 0.37 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50405 BF_2 33.90 0.53 2970 332375849 AEE63065.1 995 8.1e-105 unknown [Dendroctonus ponderosae]>gi|478259872|gb|ENN79690.1| hypothetical protein YQE_03870, partial [Dendroctonus ponderosae]>gi|546684339|gb|ERL94044.1| hypothetical protein D910_11327 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O76879 181 8.2e-12 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50407 BF_2 2.00 14.46 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50409 BF_2 81.00 2.89 1460 91094423 XP_969158.1 456 1.3e-42 PREDICTED: integrator complex subunit 12 [Tribolium castaneum]>gi|270016363|gb|EFA12809.1| hypothetical protein TcasGA2_TC001873 [Tribolium castaneum] -- -- -- -- -- K13149 INTS12 integrator complex subunit 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13149 Q6IQU7 157 2.4e-09 Integrator complex subunit 12 OS=Danio rerio GN=ints12 PE=2 SV=1 PF00130//PF05715//PF16866//PF09726//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Piccolo Zn-finger//PHD-finger//Transmembrane protein//PHD-finger GO:0035556 intracellular signal transduction GO:0046872//GO:0005515 metal ion binding//protein binding GO:0016021//GO:0045202 integral component of membrane//synapse -- -- Cluster-8309.50410 BF_2 195.20 1.28 6644 478256693 ENN76875.1 1740 7.4e-191 hypothetical protein YQE_06716, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PCB5 884 5.5e-93 Round spermatid basic protein 1-like protein OS=Homo sapiens GN=RSBN1L PE=1 SV=2 PF05059//PF06151 Orbivirus VP4 core protein//Trehalose receptor GO:0050912//GO:0007187//GO:0007607 detection of chemical stimulus involved in sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//obsolete taste perception GO:0008527 taste receptor activity GO:0016021//GO:0019028 integral component of membrane//viral capsid KOG4425 Uncharacterized conserved protein Cluster-8309.50411 BF_2 9.04 0.49 1053 91084337 XP_972793.1 665 5.3e-67 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 1.92744e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 476 1.8e-46 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- GO:0006457 protein folding GO:0031072//GO:0051082 heat shock protein binding//unfolded protein binding -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.50412 BF_2 311.00 14.99 1155 91079640 XP_968044.1 741 8.9e-76 PREDICTED: OCIA domain-containing protein 1 [Tribolium castaneum]>gi|270003372|gb|EEZ99819.1| hypothetical protein TcasGA2_TC002599 [Tribolium castaneum] 642917740 XM_962951.2 61 6.32761e-21 PREDICTED: Tribolium castaneum OCIA domain-containing protein 1 (LOC656418), mRNA -- -- -- -- Q28X44 416 1.8e-39 OCIA domain-containing protein 1 OS=Drosophila pseudoobscura pseudoobscura GN=GA12348 PE=3 SV=1 PF02637 GatB domain -- -- GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor -- -- -- -- Cluster-8309.50413 BF_2 116.00 1.59 3342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03324 Herpesvirus DNA helicase/primase complex associated protein GO:0019079 viral genome replication -- -- -- -- -- -- Cluster-8309.50415 BF_2 418.96 11.52 1808 642917276 XP_008199231.1 1232 1.6e-132 PREDICTED: capon-like protein isoform X1 [Tribolium castaneum] 685047512 LN596024.1 38 6.10712e-08 Cyprinus carpio genome assembly common carp genome ,scaffold 000002447 K16513 NOS1AP, CAPON carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein http://www.genome.jp/dbget-bin/www_bget?ko:K16513 O54960 255 1.3e-20 Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein OS=Rattus norvegicus GN=Nos1ap PE=1 SV=1 PF00640 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- KOG4815 Muscular protein implicated in muscular dystrophy phenotype Cluster-8309.50416 BF_2 99.48 3.39 1515 123482337 XP_001323756.1 297 3.6e-24 ankyrin repeat protein [Trichomonas vaginalis G3]>gi|121906627|gb|EAY11533.1| ankyrin repeat protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- K06694 PSMD10 26S proteasome non-ATPase regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06694 O70511 257 6.4e-21 Ankyrin-3 OS=Rattus norvegicus GN=Ank3 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50418 BF_2 254.73 1.75 6384 283046724 NP_001164308.1 351 8.3e-30 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 275 2.2e-22 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF13606//PF00096//PF04988//PF09153//PF07535//PF00520 Ankyrin repeat//Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//Domain of unknown function (DUF1938)//DBF zinc finger//Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005515//GO:0003677//GO:0046872//GO:0008270//GO:0005216//GO:0003676 protein binding//DNA binding//metal ion binding//zinc ion binding//ion channel activity//nucleic acid binding GO:0005634//GO:0005737//GO:0016020 nucleus//cytoplasm//membrane -- -- Cluster-8309.50421 BF_2 22.13 0.55 1960 270006730 EFA03178.1 280 4.3e-22 hypothetical protein TcasGA2_TC013098 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01254 Nuclear transition protein 2 GO:0007283 spermatogenesis GO:0003677 DNA binding GO:0000786//GO:0005634 nucleosome//nucleus -- -- Cluster-8309.50423 BF_2 50.19 0.56 4044 642935910 XP_008198225.1 1985 1.8e-219 PREDICTED: BMP-binding endothelial regulator protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N8U9 950 7.5e-101 BMP-binding endothelial regulator protein OS=Homo sapiens GN=BMPER PE=1 SV=3 PF00093//PF01479 von Willebrand factor type C domain//S4 domain -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- -- -- Cluster-8309.50424 BF_2 11.52 0.33 1768 307166389 EFN60526.1 163 1.4e-08 Protein hunchback [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50427 BF_2 77.30 1.12 3166 546673801 ERL85345.1 1621 2.2e-177 hypothetical protein D910_02765 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6GPJ5 767 9.7e-80 Leucine-rich repeat-containing protein 40 OS=Xenopus laevis GN=lrrc40 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.50428 BF_2 194.82 11.21 1014 642919633 XP_008191999.1 271 2.5e-21 PREDICTED: dopamine N acetyltransferase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94521 150 1.1e-08 Dopamine N-acetyltransferase OS=Drosophila melanogaster GN=Dat PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50430 BF_2 94.02 2.87 1657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50432 BF_2 390.64 7.89 2359 91092194 XP_969216.1 1766 2.5e-194 PREDICTED: ceramide kinase [Tribolium castaneum]>gi|270014479|gb|EFA10927.1| hypothetical protein TcasGA2_TC001754 [Tribolium castaneum] -- -- -- -- -- K04715 E2.7.1.138, CERK ceramide kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04715 Q8TCT0 672 7.5e-69 Ceramide kinase OS=Homo sapiens GN=CERK PE=1 SV=1 PF00781//PF02976 Diacylglycerol kinase catalytic domain//DNA mismatch repair enzyme MutH GO:0009395//GO:0007205//GO:0046486 phospholipid catabolic process//protein kinase C-activating G-protein coupled receptor signaling pathway//glycerolipid metabolic process GO:0004519//GO:0004143//GO:0003677//GO:0016301 endonuclease activity//diacylglycerol kinase activity//DNA binding//kinase activity -- -- KOG1115 Ceramide kinase Cluster-8309.50434 BF_2 19.51 0.41 2268 478253865 ENN74157.1 915 1.2e-95 hypothetical protein YQE_09130, partial [Dendroctonus ponderosae]>gi|546684674|gb|ERL94291.1| hypothetical protein D910_11572 [Dendroctonus ponderosae] -- -- -- -- -- K04715 E2.7.1.138, CERK ceramide kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04715 Q8TCT0 371 5.8e-34 Ceramide kinase OS=Homo sapiens GN=CERK PE=1 SV=1 PF00781 Diacylglycerol kinase catalytic domain -- -- GO:0016301 kinase activity -- -- KOG1115 Ceramide kinase Cluster-8309.50436 BF_2 3.00 1.05 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09815 XK-related protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50437 BF_2 105.65 2.55 2020 546676350 ERL87377.1 1897 1.4e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.2e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.50438 BF_2 273.00 6.65 2005 91083247 XP_973990.1 1467 1.0e-159 PREDICTED: GDP-fucose protein O-fucosyltransferase 1 [Tribolium castaneum] 195149693 XM_002015755.1 56 6.69035e-18 Drosophila persimilis GL11249 (Dper\GL11249), mRNA K03691 POFUT peptide-O-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03691 Q9V6X7 1207 5.9e-131 GDP-fucose protein O-fucosyltransferase 1 OS=Drosophila melanogaster GN=O-fut1 PE=1 SV=1 PF11547 E3 ubiquitin ligase EDD -- -- GO:0043130 ubiquitin binding -- -- KOG3849 GDP-fucose protein O-fucosyltransferase Cluster-8309.50439 BF_2 5.00 0.57 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50440 BF_2 46.00 4.27 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10808 Protein of unknown function (DUF2542) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50442 BF_2 21.00 3.45 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05851 Lentivirus virion infectivity factor (VIF) GO:0019058 viral life cycle -- -- -- -- -- -- Cluster-8309.50446 BF_2 283.38 7.79 1808 642914299 XP_008201627.1 1721 3.2e-189 PREDICTED: cytosol aminopeptidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K11142 LAP3 cytosol aminopeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K11142 Q68FS4 1104 4.7e-119 Cytosol aminopeptidase OS=Rattus norvegicus GN=Lap3 PE=1 SV=1 PF02789//PF03823//PF00883 Cytosol aminopeptidase family, N-terminal domain//Neurokinin B//Cytosol aminopeptidase family, catalytic domain GO:0006508//GO:0007217 proteolysis//tachykinin receptor signaling pathway GO:0004177 aminopeptidase activity GO:0005622 intracellular KOG2597 Predicted aminopeptidase of the M17 family Cluster-8309.50447 BF_2 41.00 12.04 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50449 BF_2 20.52 0.34 2847 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50450 BF_2 638.64 17.17 1843 478259581 ENN79434.1 765 2.3e-78 hypothetical protein YQE_04078, partial [Dendroctonus ponderosae]>gi|546686694|gb|ERL95804.1| hypothetical protein D910_00332 [Dendroctonus ponderosae]>gi|546687578|gb|ERL96217.1| hypothetical protein D910_01476 [Dendroctonus ponderosae] -- -- -- -- -- K12193 VPS24, CHMP3 charged multivesicular body protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12193 Q4R574 597 2.9e-60 Charged multivesicular body protein 3 OS=Macaca fascicularis GN=CHMP3 PE=2 SV=3 PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- KOG3229 Vacuolar sorting protein VPS24 Cluster-8309.50451 BF_2 207.01 1.87 4916 189237113 XP_971629.2 1209 2.1e-129 PREDICTED: xyloside xylosyltransferase 1 [Tribolium castaneum]>gi|270007231|gb|EFA03679.1| hypothetical protein TcasGA2_TC013781 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBI6 600 3.5e-60 Xyloside xylosyltransferase 1 OS=Homo sapiens GN=XXYLT1 PE=1 SV=1 PF12763//PF13202//PF13499//PF13405//PF13833//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand -- -- GO:0016757//GO:0005509//GO:0005515 transferase activity, transferring glycosyl groups//calcium ion binding//protein binding -- -- KOG0032 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.50453 BF_2 154.73 4.18 1834 478252879 ENN73268.1 274 2.0e-21 hypothetical protein YQE_10163, partial [Dendroctonus ponderosae]>gi|546673885|gb|ERL85407.1| hypothetical protein D910_02827, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50458 BF_2 9.00 0.63 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50462 BF_2 40.15 0.45 4011 642910697 XP_008200065.1 946 5.3e-99 PREDICTED: uncharacterized protein LOC103314827 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09107 Elongation factor SelB, winged helix GO:0001514//GO:0006448 selenocysteine incorporation//regulation of translational elongation GO:0003723//GO:0005525//GO:0003746 RNA binding//GTP binding//translation elongation factor activity GO:0005737//GO:0005840 cytoplasm//ribosome -- -- Cluster-8309.50463 BF_2 32.00 1.71 1070 817054398 XP_012267380.1 183 4.2e-11 PREDICTED: THAP domain-containing protein 1-like isoform X2 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.50466 BF_2 47.80 1.03 2238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50467 BF_2 59.95 0.87 3160 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50468 BF_2 965.39 3.40 12152 642913340 XP_008195316.1 15018 0.0e+00 PREDICTED: WD repeat and FYVE domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270002019|gb|EEZ98466.1| hypothetical protein TcasGA2_TC000957 [Tribolium castaneum] 572266379 XM_006611237.1 593 0 PREDICTED: Apis dorsata WD repeat and FYVE domain-containing protein 3-like (LOC102679853), mRNA -- -- -- -- Q8IZQ1 5442 0.0e+00 WD repeat and FYVE domain-containing protein 3 OS=Homo sapiens GN=WDFY3 PE=1 SV=2 PF00400//PF01363 WD domain, G-beta repeat//FYVE zinc finger -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- KOG1786 Lysosomal trafficking regulator LYST and related BEACH and WD40 repeat proteins Cluster-8309.50470 BF_2 162.46 2.31 3232 642915724 XP_008190776.1 1435 8.4e-156 PREDICTED: serine/threonine-protein kinase VRK1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q32PI1 400 3.6e-37 Serine/threonine-protein kinase VRK1 OS=Bos taurus GN=VRK1 PE=2 SV=1 PF07714//PF00069//PF03047 Protein tyrosine kinase//Protein kinase domain//COMC family GO:0007165//GO:0006468 signal transduction//protein phosphorylation GO:0005524//GO:0004672//GO:0005186 ATP binding//protein kinase activity//pheromone activity -- -- KOG1164 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.50474 BF_2 104.10 1.95 2516 642925371 XP_008194521.1 312 1.1e-25 PREDICTED: zinc finger protein 600-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 222 1.2e-16 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF04988//PF13465//PF00096 A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.50475 BF_2 13.29 0.50 1393 546673850 ERL85380.1 1204 2.2e-129 hypothetical protein D910_02800 [Dendroctonus ponderosae] 157136796 XM_001656862.1 144 5.55843e-67 Aedes aegypti AAEL003514-RA mRNA K11131 DKC1, NOLA4, CBF5 H/ACA ribonucleoprotein complex subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11131 O44081 1174 2.7e-127 H/ACA ribonucleoprotein complex subunit 4 OS=Drosophila melanogaster GN=Nop60B PE=1 SV=1 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG2529 Pseudouridine synthase Cluster-8309.50476 BF_2 249.53 2.06 5343 390362249 XP_001190749.2 1582 1.3e-172 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 851 3.0e-89 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF01637//PF13606//PF00866//PF00023//PF00906 Archaeal ATPase//Ankyrin repeat//Ring hydroxylating beta subunit//Ankyrin repeat//Hepatitis core antigen GO:0009405//GO:0055114//GO:0006725 pathogenesis//oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824//GO:0005524//GO:0005198//GO:0005515 catalytic activity//ATP binding//structural molecule activity//protein binding -- -- -- -- Cluster-8309.50478 BF_2 3.27 0.55 538 332374294 AEE62288.1 262 1.4e-20 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50481 BF_2 3.00 1.25 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50483 BF_2 7.00 0.60 775 808859777 KKF11870.1 1235 3.1e-133 Tubulin alpha-1C chain [Larimichthys crocea] 262401096 FJ774729.1 736 0 Scylla paramamosain alpha-I tubulin mRNA, partial cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q25008 1257 3.6e-137 Tubulin alpha-1 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.50484 BF_2 3.00 1.16 394 330976859 AEC48728.1 565 7.8e-56 alpha-tubulin [Eriocheir sinensis] 330976858 HQ436507.1 194 2.37129e-95 Eriocheir sinensis alpha-tubulin mRNA, complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P41383 548 3.0e-55 Tubulin alpha-2/alpha-4 chain OS=Patella vulgata GN=TUB2 PE=2 SV=1 PF13912//PF00091//PF11057 C2H2-type zinc finger//Tubulin/FtsZ family, GTPase domain//Cortexin of kidney -- -- GO:0046872//GO:0003924 metal ion binding//GTPase activity GO:0031224 intrinsic component of membrane KOG1376 Alpha tubulin Cluster-8309.50488 BF_2 10.00 1.56 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50492 BF_2 49.40 0.84 2744 91085763 XP_974155.1 1911 4.5e-211 PREDICTED: polyribonucleotide nucleotidyltransferase 1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270009999|gb|EFA06447.1| hypothetical protein TcasGA2_TC009329 [Tribolium castaneum] -- -- -- -- -- K00962 pnp, PNPT1 polyribonucleotide nucleotidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00962 Q8K1R3 1319 8.3e-144 Polyribonucleotide nucleotidyltransferase 1, mitochondrial OS=Mus musculus GN=Pnpt1 PE=1 SV=1 PF03726//PF00575 Polyribonucleotide nucleotidyltransferase, RNA binding domain//S1 RNA binding domain GO:0006144//GO:0006402//GO:0006396//GO:0051252//GO:0006206 purine nucleobase metabolic process//mRNA catabolic process//RNA processing//regulation of RNA metabolic process//pyrimidine nucleobase metabolic process GO:0000175//GO:0003723//GO:0004654//GO:0003676 3'-5'-exoribonuclease activity//RNA binding//polyribonucleotide nucleotidyltransferase activity//nucleic acid binding -- -- KOG1067 Predicted RNA-binding polyribonucleotide nucleotidyltransferase Cluster-8309.50493 BF_2 86.89 0.83 4661 642911186 XP_008199538.1 3936 0.0e+00 PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911188|ref|XP_008199542.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911190|ref|XP_008199549.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum]>gi|642911192|ref|XP_008199550.1| PREDICTED: inositol 1,4,5-trisphosphate receptor isoform X1 [Tribolium castaneum] 198453821 XM_001359317.2 76 1.19679e-28 Drosophila pseudoobscura pseudoobscura GA10452 (Dpse\GA10452), partial mRNA K04958 ITPR1 inositol 1,4,5-triphosphate receptor type 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04958 P29993 3156 0.0e+00 Inositol 1,4,5-trisphosphate receptor OS=Drosophila melanogaster GN=Itp-r83A PE=2 SV=3 PF08702//PF00520 Fibrinogen alpha/beta chain family//Ion transport protein GO:0007165//GO:0055085//GO:0051258//GO:0030168//GO:0006811 signal transduction//transmembrane transport//protein polymerization//platelet activation//ion transport GO:0030674//GO:0005216//GO:0005102 protein binding, bridging//ion channel activity//receptor binding GO:0016020//GO:0005577 membrane//fibrinogen complex KOG3533 Inositol 1,4,5-trisphosphate receptor Cluster-8309.50495 BF_2 9.36 0.31 1547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01325 Iron dependent repressor, N-terminal DNA binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.50497 BF_2 127.49 0.87 6437 642912571 XP_008200914.1 1898 3.4e-209 PREDICTED: guanine nucleotide-releasing factor 2 isoform X2 [Tribolium castaneum] 755946791 XM_011301952.1 195 1.16739e-94 PREDICTED: Fopius arisanus guanine nucleotide-releasing factor 2 (LOC105264812), transcript variant X5, mRNA K06277 RAPGEF1, GRF2 Rap guanine nucleotide exchange factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06277 O77086 1025 2.4e-109 Guanine nucleotide-releasing factor 2 OS=Drosophila melanogaster GN=C3G PE=1 SV=4 PF00617 RasGEF domain GO:0043087//GO:0007264 regulation of GTPase activity//small GTPase mediated signal transduction GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.50502 BF_2 98.33 3.01 1653 91078380 XP_974219.1 194 3.4e-12 PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum]>gi|642915348|ref|XP_008190582.1| PREDICTED: uncharacterized protein LOC663065 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03310//PF02176//PF03145//PF00876 Caulimovirus DNA-binding protein//TRAF-type zinc finger//Seven in absentia protein family//Innexin GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0003677//GO:0008270 DNA binding//zinc ion binding GO:0005921//GO:0005634 gap junction//nucleus -- -- Cluster-8309.50503 BF_2 12.08 1.71 583 642914727 XP_008190326.1 269 2.4e-21 PREDICTED: pH-sensitive chloride channel isoform X7 [Tribolium castaneum] 642914730 XM_008192107.1 127 6.33882e-58 PREDICTED: Tribolium castaneum pH sensitive chloride channel (Phcl), transcript variant X8, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50504 BF_2 134.77 1.39 4338 478258110 ENN78248.1 2446 6.6e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 3.50025e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 2.5e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF00400//PF08063//PF01435//PF01433//PF09127 WD domain, G-beta repeat//PADR1 (NUC008) domain//Peptidase family M48//Peptidase family M1//Leukotriene A4 hydrolase, C-terminal GO:0006508//GO:0019370 proteolysis//leukotriene biosynthetic process GO:0008237//GO:0008270//GO:0003950//GO:0004222//GO:0005515 metallopeptidase activity//zinc ion binding//NAD+ ADP-ribosyltransferase activity//metalloendopeptidase activity//protein binding GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.50505 BF_2 92.17 0.77 5283 478258110 ENN78248.1 2446 8.1e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 4.26913e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 3.1e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF01435//PF00400//PF08063//PF09127//PF01433 Peptidase family M48//WD domain, G-beta repeat//PADR1 (NUC008) domain//Leukotriene A4 hydrolase, C-terminal//Peptidase family M1 GO:0019370//GO:0006508 leukotriene biosynthetic process//proteolysis GO:0005515//GO:0004222//GO:0003950//GO:0008270//GO:0008237 protein binding//metalloendopeptidase activity//NAD+ ADP-ribosyltransferase activity//zinc ion binding//metallopeptidase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.50506 BF_2 20.90 0.42 2381 26324131 AAN77377.1 2686 5.4e-301 smooth endoplasmic reticulum calcium ATPase [Porcellio scaber] 378947922 JN986572.1 799 0 Litopenaeus vannamei sarco/endoplasmic reticulum Ca2+-ATPase mRNA, complete cds K05853 ATP2A Ca2+ transporting ATPase, sarcoplasmic/endoplasmic reticulum http://www.genome.jp/dbget-bin/www_bget?ko:K05853 Q7PPA5 2456 1.0e-275 Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type OS=Anopheles gambiae GN=Ca-P60A PE=3 SV=5 -- -- -- -- -- -- -- -- KOG0202 Ca2+ transporting ATPase Cluster-8309.50508 BF_2 92.88 1.66 2631 642930462 XP_008196413.1 2319 2.1e-258 PREDICTED: phosphofurin acidic cluster sorting protein 1 [Tribolium castaneum]>gi|270009398|gb|EFA05846.1| hypothetical protein TcasGA2_TC008635 [Tribolium castaneum] 558214452 XM_006108296.1 57 2.45127e-18 PREDICTED: Myotis lucifugus phosphofurin acidic cluster sorting protein 2 (PACS2), partial mRNA -- -- -- -- Q6VY07 359 1.7e-32 Phosphofurin acidic cluster sorting protein 1 OS=Homo sapiens GN=PACS1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3709 PACS-1 cytosolic sorting protein Cluster-8309.50511 BF_2 150.90 4.80 1601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50512 BF_2 400.60 7.62 2485 270003665 EFA00113.1 1871 1.8e-206 hypothetical protein TcasGA2_TC002929 [Tribolium castaneum] 642916327 XM_008192753.1 606 0 PREDICTED: Tribolium castaneum glucose transporter type 1 (LOC663886), transcript variant X2, mRNA K07299 SLC2A1, GLUT1 MFS transporter, SP family, solute carrier family 2 (facilitated glucose transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07299 Q8IRI6 1796 3.7e-199 Glucose transporter type 1 OS=Drosophila melanogaster GN=Glut1 PE=2 SV=4 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0569 Permease of the major facilitator superfamily Cluster-8309.50513 BF_2 80.62 1.16 3204 270009489 EFA05937.1 1625 7.7e-178 hypothetical protein TcasGA2_TC008753 [Tribolium castaneum] 642929936 XM_008197811.1 369 0 PREDICTED: Tribolium castaneum nucleolar protein 4-like (LOC664605), transcript variant X1, mRNA -- -- -- -- Q96MY1 448 9.6e-43 Nucleolar protein 4-like OS=Homo sapiens GN=NOL4L PE=1 SV=2 PF09026 Centromere protein B dimerisation domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003682 DNA binding//chromatin binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region -- -- Cluster-8309.50515 BF_2 6.61 1.22 513 769856846 XP_011640032.1 138 3.3e-06 PREDICTED: longitudinals lacking protein, isoforms A/B/D/L isoform X39 [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16622//PF02892//PF01708//PF13912//PF00096//PF13465 zinc-finger C2H2-type//BED zinc finger//Geminivirus putative movement protein//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0046740 transport of virus in host, cell to cell GO:0003677//GO:0046872 DNA binding//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.50518 BF_2 54.40 1.67 1648 642913824 XP_008201175.1 211 3.6e-14 PREDICTED: microtubule-associated protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05296 Taste receptor protein (TAS2R) GO:0007186//GO:0050909 G-protein coupled receptor signaling pathway//sensory perception of taste GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50521 BF_2 55.00 0.61 4035 546673724 ERL85280.1 3262 0.0e+00 hypothetical protein D910_02701 [Dendroctonus ponderosae] 756767049 KJ699123.1 896 0 Brassicogethes aeneus isolate Wlkp_PL voltage-sensitive sodium channel mRNA, complete cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 2894 0.0e+00 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF00520//PF02163//PF02297 Ion transport protein//Peptidase family M50//Cytochrome oxidase c subunit VIb GO:0055085//GO:0006123//GO:0006508//GO:0006811//GO:0015992 transmembrane transport//mitochondrial electron transport, cytochrome c to oxygen//proteolysis//ion transport//proton transport GO:0004222//GO:0005216//GO:0004129 metalloendopeptidase activity//ion channel activity//cytochrome-c oxidase activity GO:0045277//GO:0016020//GO:0005739 respiratory chain complex IV//membrane//mitochondrion -- -- Cluster-8309.50524 BF_2 160.69 4.41 1812 270009226 EFA05674.1 1385 3.0e-150 hypothetical protein TcasGA2_TC015033 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AXF6 733 4.9e-76 SID1 transmembrane family member 1 OS=Mus musculus GN=Sidt1 PE=2 SV=1 PF01040//PF13965 UbiA prenyltransferase family//dsRNA-gated channel SID-1 GO:0015931//GO:0033227 nucleobase-containing compound transport//dsRNA transport GO:0004659//GO:0051033 prenyltransferase activity//RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.50526 BF_2 222.64 1.57 6221 571535227 XP_006568313.1 6105 0.0e+00 PREDICTED: neurobeachin-like [Apis mellifera] 817185259 XM_012430472.1 851 0 PREDICTED: Orussus abietinus neurobeachin (LOC105702683), transcript variant X7, mRNA -- -- -- -- Q8NFP9 3084 0.0e+00 Neurobeachin OS=Homo sapiens GN=NBEA PE=1 SV=3 PF10508//PF10798 Proteasome non-ATPase 26S subunit//Biofilm development protein YmgB/AriR GO:0071229//GO:0042710//GO:0043248 cellular response to acid chemical//biofilm formation//proteasome assembly -- -- -- -- KOG1787 Kinase A-anchor protein Neurobeachin and related BEACH and WD40 repeat proteins Cluster-8309.50527 BF_2 89.00 2.80 1618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50528 BF_2 90.43 2.15 2047 642936881 XP_008194325.1 316 3.0e-26 PREDICTED: uncharacterized protein LOC103313261 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50530 BF_2 58.56 0.58 4509 478257181 ENN77344.1 1760 2.4e-193 hypothetical protein YQE_06170, partial [Dendroctonus ponderosae]>gi|546681413|gb|ERL91510.1| hypothetical protein D910_08840 [Dendroctonus ponderosae] -- -- -- -- -- K10263 FBXW5 F-box and WD-40 domain protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K10263 Q9QXW2 697 1.8e-71 F-box/WD repeat-containing protein 5 OS=Mus musculus GN=Fbxw5 PE=1 SV=1 PF12937//PF09026//PF00400//PF00646//PF00355 F-box-like//Centromere protein B dimerisation domain//WD domain, G-beta repeat//F-box domain//Rieske [2Fe-2S] domain GO:0006355//GO:0055114 regulation of transcription, DNA-templated//oxidation-reduction process GO:0003677//GO:0051537//GO:0016491//GO:0005515//GO:0003682 DNA binding//2 iron, 2 sulfur cluster binding//oxidoreductase activity//protein binding//chromatin binding GO:0000785//GO:0005634//GO:0000775 chromatin//nucleus//chromosome, centromeric region KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.50532 BF_2 425.00 16.42 1370 91081201 XP_975610.1 1253 4.5e-135 PREDICTED: peptidylglycine alpha-hydroxylating monooxygenase [Tribolium castaneum]>gi|270005264|gb|EFA01712.1| hypothetical protein TcasGA2_TC007292 [Tribolium castaneum] -- -- -- -- -- K00504 PAM, PHM peptidylglycine monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K00504 O01404 924 2.6e-98 Peptidylglycine alpha-hydroxylating monooxygenase OS=Drosophila melanogaster GN=Phm PE=1 SV=2 PF01082 Copper type II ascorbate-dependent monooxygenase, N-terminal domain GO:0006518//GO:0055114 peptide metabolic process//oxidation-reduction process GO:0004504//GO:0005507//GO:0016715//GO:0004497 peptidylglycine monooxygenase activity//copper ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity GO:0016020 membrane KOG3567 Peptidylglycine alpha-amidating monooxygenase Cluster-8309.50535 BF_2 448.97 9.46 2273 91092806 XP_967025.1 2140 1.1e-237 PREDICTED: protein henna [Tribolium castaneum]>gi|270003060|gb|EEZ99507.1| hypothetical protein TcasGA2_TC000087 [Tribolium castaneum] -- -- -- -- -- K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1717 4.9e-190 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF00351//PF01842 Biopterin-dependent aromatic amino acid hydroxylase//ACT domain GO:0008152//GO:0000162//GO:0006571//GO:0055114//GO:0006559//GO:0009094 metabolic process//tryptophan biosynthetic process//tyrosine biosynthetic process//oxidation-reduction process//L-phenylalanine catabolic process//L-phenylalanine biosynthetic process GO:0016714//GO:0005506//GO:0004505//GO:0016597 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//iron ion binding//phenylalanine 4-monooxygenase activity//amino acid binding -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.50537 BF_2 207.67 2.60 3632 478258640 ENN78690.1 1014 6.2e-107 hypothetical protein YQE_04862, partial [Dendroctonus ponderosae]>gi|546685796|gb|ERL95245.1| hypothetical protein D910_12512 [Dendroctonus ponderosae] -- -- -- -- -- K07966 B4GALT1 beta-1,4-galactosyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07966 Q80WN7 486 4.3e-47 Beta-1,4-galactosyltransferase 4 OS=Cricetulus griseus GN=B4GALT4 PE=2 SV=1 PF05679//PF03279 Chondroitin N-acetylgalactosaminyltransferase//Bacterial lipid A biosynthesis acyltransferase -- -- GO:0008376//GO:0016740 acetylgalactosaminyltransferase activity//transferase activity GO:0016021//GO:0032580 integral component of membrane//Golgi cisterna membrane KOG3916 UDP-Gal:glucosylceramide beta-1,4-galactosyltransferase Cluster-8309.50539 BF_2 104.11 0.42 10756 642914930 XP_008190446.1 6308 0.0e+00 PREDICTED: protein slit isoform X3 [Tribolium castaneum] 462424845 APGK01016975.1 99 4.54251e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 4797 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF00560//PF07645//PF13639//PF05463//PF00097//PF00008//PF14634//PF13855 Leucine Rich Repeat//Calcium-binding EGF domain//Ring finger domain//Sclerostin (SOST)//Zinc finger, C3HC4 type (RING finger)//EGF-like domain//zinc-RING finger domain//Leucine rich repeat -- -- GO:0008270//GO:0005509//GO:0005515//GO:0046872 zinc ion binding//calcium ion binding//protein binding//metal ion binding GO:0005615 extracellular space KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.5054 BF_2 56.78 5.04 758 478260467 ENN80187.1 142 1.7e-06 hypothetical protein YQE_03382, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02723 Non-structural protein NS3/Small envelope protein E -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.50540 BF_2 12.93 0.34 1899 642914052 XP_969243.3 1511 7.6e-165 PREDICTED: sorting nexin-6 isoform X2 [Tribolium castaneum]>gi|270001606|gb|EEZ98053.1| hypothetical protein TcasGA2_TC000458 [Tribolium castaneum] 697469095 XM_009669926.1 81 8.01687e-32 PREDICTED: Struthio camelus australis sorting nexin 6 (SNX6), transcript variant X2, mRNA K17920 SNX5_6_32 sorting nexin-5/6/32 http://www.genome.jp/dbget-bin/www_bget?ko:K17920 Q5R613 931 5.6e-99 Sorting nexin-6 OS=Pongo abelii GN=SNX6 PE=2 SV=1 PF01916//PF04632//PF00787 Deoxyhypusine synthase//Fusaric acid resistance protein family//PX domain GO:0007154//GO:0006810//GO:0008612 cell communication//transport//peptidyl-lysine modification to peptidyl-hypusine GO:0035091 phosphatidylinositol binding GO:0005886 plasma membrane KOG1660 Sorting nexin SNX6/TFAF2, contains PX domain Cluster-8309.50542 BF_2 87.38 5.82 915 642926314 XP_008194873.1 883 2.4e-92 PREDICTED: bicaudal D-related protein homolog isoform X1 [Tribolium castaneum]>gi|642926316|ref|XP_008194874.1| PREDICTED: bicaudal D-related protein homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 446 4.7e-43 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF01920//PF13851//PF10473 Prefoldin subunit//Growth-arrest specific micro-tubule binding//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006457//GO:0048870 protein folding//cell motility GO:0051082//GO:0042803//GO:0008134//GO:0045502 unfolded protein binding//protein homodimerization activity//transcription factor binding//dynein binding GO:0016272//GO:0030286//GO:0031514//GO:0005667 prefoldin complex//dynein complex//motile cilium//transcription factor complex -- -- Cluster-8309.50543 BF_2 50.46 0.63 3620 189238478 XP_968757.2 850 6.4e-88 PREDICTED: bicaudal D-related protein homolog isoform X2 [Tribolium castaneum] 195590137 XM_002084767.1 68 2.59687e-24 Drosophila simulans GD14464 (Dsim\GD14464), mRNA K16756 CCDC64 coiled-coil domain-containing protein 64 http://www.genome.jp/dbget-bin/www_bget?ko:K16756 Q8SWR2 443 4.1e-42 Bicaudal D-related protein homolog OS=Drosophila melanogaster GN=CG17365 PE=2 SV=1 PF10473//PF13851//PF01920//PF01544 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Growth-arrest specific micro-tubule binding//Prefoldin subunit//CorA-like Mg2+ transporter protein GO:0006457//GO:0055085//GO:0030001//GO:0048870 protein folding//transmembrane transport//metal ion transport//cell motility GO:0046873//GO:0051082//GO:0042803//GO:0008134//GO:0045502 metal ion transmembrane transporter activity//unfolded protein binding//protein homodimerization activity//transcription factor binding//dynein binding GO:0016020//GO:0016272//GO:0031514//GO:0030286//GO:0005667 membrane//prefoldin complex//motile cilium//dynein complex//transcription factor complex -- -- Cluster-8309.50544 BF_2 10.00 0.37 1407 546681029 ERL91194.1 212 2.4e-14 hypothetical protein D910_08533 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01290 Thymosin beta-4 family GO:0007015 actin filament organization GO:0003785 actin monomer binding -- -- -- -- Cluster-8309.50548 BF_2 442.39 1.32 14311 189241098 XP_971301.2 12901 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13D [Tribolium castaneum] -- -- -- -- -- K19527 VPS13D vacuolar protein sorting-associated protein 13D http://www.genome.jp/dbget-bin/www_bget?ko:K19527 Q5THJ4 2461 1.6e-275 Vacuolar protein sorting-associated protein 13D OS=Homo sapiens GN=VPS13D PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.50549 BF_2 50.49 0.41 5482 642939323 XP_969087.2 928 8.8e-97 PREDICTED: aminoacyl tRNA synthase complex-interacting multifunctional protein 1 isoform X1 [Tribolium castaneum] 826415001 XM_012666755.1 37 6.74475e-07 PREDICTED: Monomorium pharaonis arginine/serine-rich protein PNISR (LOC105828433), transcript variant X2, mRNA K15437 AIMP1, ARC1 aminoacyl tRNA synthase complex-interacting multifunctional protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15437 O54873 578 1.4e-57 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 OS=Cricetulus griseus GN=AIMP1 PE=2 SV=1 PF03876//PF01588 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Putative tRNA binding domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0000049 DNA-directed RNA polymerase activity//tRNA binding GO:0005730 nucleolus KOG2241 tRNA-binding protein Cluster-8309.50551 BF_2 587.59 3.16 8056 642934473 XP_008197678.1 5966 0.0e+00 PREDICTED: kinase D-interacting substrate of 220 kDa isoform X2 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 3.3e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF00536//PF06553//PF13606//PF00023 SAM domain (Sterile alpha motif)//BNIP3//Ankyrin repeat//Ankyrin repeat GO:0043065 positive regulation of apoptotic process GO:0005515 protein binding GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.50556 BF_2 1183.67 21.88 2550 91088067 XP_967758.1 898 1.2e-93 PREDICTED: UPF0047 protein C4A8.02c [Tribolium castaneum]>gi|270011871|gb|EFA08319.1| hypothetical protein TcasGA2_TC005961 [Tribolium castaneum] 642931137 XM_962665.2 338 1.47429e-174 PREDICTED: Tribolium castaneum UPF0047 protein C4A8.02c (LOC656116), mRNA -- -- -- -- P0AF49 389 5.3e-36 UPF0047 protein YjbQ OS=Escherichia coli O157:H7 GN=yjbQ PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3267 Uncharacterized conserved protein Cluster-8309.50557 BF_2 26.00 0.66 1938 -- -- -- -- -- 462278079 APGK01058767.1 46 2.34094e-12 Dendroctonus ponderosae Seq01058777, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50558 BF_2 156.92 1.91 3718 546684844 ERL94426.1 2239 5.7e-249 hypothetical protein D910_11704 [Dendroctonus ponderosae] -- -- -- -- -- K01769 E4.6.1.2 guanylate cyclase, other http://www.genome.jp/dbget-bin/www_bget?ko:K01769 Q9VEU6 1251 8.6e-136 Soluble guanylate cyclase 89Da OS=Drosophila melanogaster GN=Gyc-89Da PE=1 SV=2 PF07701//PF00211//PF07700 Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain//Haem-NO-binding GO:0035556//GO:0009190//GO:0006182//GO:0046039//GO:0006144 intracellular signal transduction//cyclic nucleotide biosynthetic process//cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process GO:0004383//GO:0016849//GO:0020037 guanylate cyclase activity//phosphorus-oxygen lyase activity//heme binding -- -- KOG4171 Adenylate/guanylate kinase Cluster-8309.50559 BF_2 133.96 0.94 6256 478257502 ENN77658.1 2749 7.0e-308 hypothetical protein YQE_05952, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q13439 325 3.4e-28 Golgin subfamily A member 4 OS=Homo sapiens GN=GOLGA4 PE=1 SV=1 PF01465 GRIP domain GO:0000042 protein targeting to Golgi GO:0005515 protein binding -- -- -- -- Cluster-8309.50562 BF_2 98.74 0.69 6257 546674893 ERL86179.1 2180 6.7e-242 hypothetical protein D910_03592, partial [Dendroctonus ponderosae] 755849126 XM_011298332.1 209 1.87184e-102 PREDICTED: Musca domestica protein grainyhead (LOC101890862), transcript variant X6, mRNA K09275 TFCP2 transcription factor CP2 and related proteins http://www.genome.jp/dbget-bin/www_bget?ko:K09275 P13002 1751 1.5e-193 Protein grainyhead OS=Drosophila melanogaster GN=grh PE=2 SV=3 -- -- -- -- -- -- -- -- KOG4091 Transcription factor Cluster-8309.50564 BF_2 423.60 13.29 1621 642919866 XP_008192101.1 1717 8.4e-189 PREDICTED: uridine 5'-monophosphate synthase [Tribolium castaneum] -- -- -- -- -- K13421 UMPS uridine monophosphate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K13421 Q01637 1272 1.4e-138 Uridine 5'-monophosphate synthase OS=Drosophila melanogaster GN=r-l PE=2 SV=2 PF00156//PF00215 Phosphoribosyl transferase domain//Orotidine 5'-phosphate decarboxylase / HUMPS family GO:0006207//GO:0006206//GO:0009116 'de novo' pyrimidine nucleobase biosynthetic process//pyrimidine nucleobase metabolic process//nucleoside metabolic process GO:0004590 orotidine-5'-phosphate decarboxylase activity -- -- KOG1377 Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase Cluster-8309.50565 BF_2 15.40 0.49 1592 478250399 ENN70894.1 1523 2.6e-166 hypothetical protein YQE_12299, partial [Dendroctonus ponderosae]>gi|546672890|gb|ERL84613.1| hypothetical protein D910_02041 [Dendroctonus ponderosae] -- -- -- -- -- K13421 UMPS uridine monophosphate synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K13421 Q01637 1121 4.4e-121 Uridine 5'-monophosphate synthase OS=Drosophila melanogaster GN=r-l PE=2 SV=2 PF00156//PF00215 Phosphoribosyl transferase domain//Orotidine 5'-phosphate decarboxylase / HUMPS family GO:0006207//GO:0009116//GO:0006206 'de novo' pyrimidine nucleobase biosynthetic process//nucleoside metabolic process//pyrimidine nucleobase metabolic process GO:0004590 orotidine-5'-phosphate decarboxylase activity -- -- KOG1377 Uridine 5'- monophosphate synthase/orotate phosphoribosyltransferase Cluster-8309.50569 BF_2 4.00 0.37 740 91091456 XP_972862.1 193 2.0e-12 PREDICTED: aquaporin AQPcic [Tribolium castaneum]>gi|270000980|gb|EEZ97427.1| hypothetical protein TcasGA2_TC011257 [Tribolium castaneum] -- -- -- -- -- K09884 AQPN aquaporin rerated protein, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K09884 Q25074 178 4.5e-12 Aquaporin OS=Haematobia irritans exigua PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.50571 BF_2 23.13 0.97 1284 642918880 XP_008191625.1 1026 8.9e-109 PREDICTED: probable ATP-dependent RNA helicase DDX49 [Tribolium castaneum] 769857380 XM_011642027.1 37 1.54734e-07 PREDICTED: Pogonomyrmex barbatus probable ATP-dependent RNA helicase DDX10 (LOC105429200), mRNA K14778 DDX49, DBP8 ATP-dependent RNA helicase DDX49/DBP8 http://www.genome.jp/dbget-bin/www_bget?ko:K14778 Q9Y6V7 778 2.1e-81 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens GN=DDX49 PE=1 SV=1 PF00270//PF04851//PF00176 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0005524//GO:0003676//GO:0003677//GO:0016787 ATP binding//nucleic acid binding//DNA binding//hydrolase activity -- -- KOG0340 ATP-dependent RNA helicase Cluster-8309.50572 BF_2 402.87 10.65 1869 642918880 XP_008191625.1 1769 9.1e-195 PREDICTED: probable ATP-dependent RNA helicase DDX49 [Tribolium castaneum] 471223534 XM_004030496.1 44 2.9184e-11 Ichthyophthirius multifiliis hypothetical protein (IMG5_158860) mRNA, partial cds K14778 DDX49, DBP8 ATP-dependent RNA helicase DDX49/DBP8 http://www.genome.jp/dbget-bin/www_bget?ko:K14778 Q9Y6V7 1283 8.4e-140 Probable ATP-dependent RNA helicase DDX49 OS=Homo sapiens GN=DDX49 PE=1 SV=1 PF00270//PF04851//PF00176 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0005524//GO:0003676//GO:0003677//GO:0016787 ATP binding//nucleic acid binding//DNA binding//hydrolase activity -- -- KOG0340 ATP-dependent RNA helicase Cluster-8309.50575 BF_2 25.00 0.82 1558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50579 BF_2 238.97 5.15 2227 642912148 XP_008200826.1 1887 2.2e-208 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 484 4.5e-47 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF07196//PF01757 Flagellin hook IN motif//Acyltransferase family GO:0006928//GO:0044781 movement of cell or subcellular component//bacterial-type flagellum organization GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0009288 bacterial-type flagellum -- -- Cluster-8309.50587 BF_2 369.62 11.57 1623 91076806 XP_974293.1 777 8.4e-80 PREDICTED: sorting nexin-12 [Tribolium castaneum]>gi|270001843|gb|EEZ98290.1| hypothetical protein TcasGA2_TC000739 [Tribolium castaneum] -- -- -- -- -- K17918 SNX3_12 sorting nexin-3/12 http://www.genome.jp/dbget-bin/www_bget?ko:K17918 Q9UMY4 597 2.6e-60 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 PF00233//PF00787 3'5'-cyclic nucleotide phosphodiesterase//PX domain GO:0007154//GO:0006144//GO:0007165 cell communication//purine nucleobase metabolic process//signal transduction GO:0035091//GO:0004114 phosphatidylinositol binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG2527 Sorting nexin SNX11 Cluster-8309.50588 BF_2 81.47 1.53 2518 91076806 XP_974293.1 777 1.3e-79 PREDICTED: sorting nexin-12 [Tribolium castaneum]>gi|270001843|gb|EEZ98290.1| hypothetical protein TcasGA2_TC000739 [Tribolium castaneum] -- -- -- -- -- K17918 SNX3_12 sorting nexin-3/12 http://www.genome.jp/dbget-bin/www_bget?ko:K17918 Q9UMY4 597 4.0e-60 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 PF00233//PF00787 3'5'-cyclic nucleotide phosphodiesterase//PX domain GO:0006144//GO:0007154//GO:0007165 purine nucleobase metabolic process//cell communication//signal transduction GO:0035091//GO:0004114 phosphatidylinositol binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG2527 Sorting nexin SNX11 Cluster-8309.50589 BF_2 61.90 1.19 2459 91076806 XP_974293.1 777 1.3e-79 PREDICTED: sorting nexin-12 [Tribolium castaneum]>gi|270001843|gb|EEZ98290.1| hypothetical protein TcasGA2_TC000739 [Tribolium castaneum] -- -- -- -- -- K17918 SNX3_12 sorting nexin-3/12 http://www.genome.jp/dbget-bin/www_bget?ko:K17918 Q9UMY4 597 3.9e-60 Sorting nexin-12 OS=Homo sapiens GN=SNX12 PE=1 SV=3 PF00233//PF00787 3'5'-cyclic nucleotide phosphodiesterase//PX domain GO:0007154//GO:0006144//GO:0007165 cell communication//purine nucleobase metabolic process//signal transduction GO:0035091//GO:0004114 phosphatidylinositol binding//3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG2527 Sorting nexin SNX11 Cluster-8309.50593 BF_2 174.00 9.76 1033 332374840 AEE62561.1 651 2.2e-65 unknown [Dendroctonus ponderosae]>gi|546685384|gb|ERL94902.1| hypothetical protein D910_12175 [Dendroctonus ponderosae] -- -- -- -- -- K06134 COQ7 ubiquinone biosynthesis monooxygenase Coq7 http://www.genome.jp/dbget-bin/www_bget?ko:K06134 Q99807 459 1.6e-44 5-demethoxyubiquinone hydroxylase, mitochondrial OS=Homo sapiens GN=COQ7 PE=1 SV=3 PF03232//PF02915 Ubiquinone biosynthesis protein COQ7//Rubrerythrin GO:0055114//GO:0006744 oxidation-reduction process//ubiquinone biosynthetic process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- KOG4061 DMQ mono-oxygenase/Ubiquinone biosynthesis protein COQ7/CLK-1/CAT5 Cluster-8309.50594 BF_2 11.00 0.69 951 641669667 XP_008184906.1 270 3.0e-21 PREDICTED: uncharacterized protein LOC100574215 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50595 BF_2 18.59 0.62 1544 91082001 XP_969328.1 541 1.9e-52 PREDICTED: vacuolar protein sorting-associated protein 37A [Tribolium castaneum]>gi|270007313|gb|EFA03761.1| hypothetical protein TcasGA2_TC013872 [Tribolium castaneum] -- -- -- -- -- K12185 VPS37 ESCRT-I complex subunit VPS37 http://www.genome.jp/dbget-bin/www_bget?ko:K12185 Q8CHS8 192 2.2e-13 Vacuolar protein sorting-associated protein 37A OS=Mus musculus GN=Vps37a PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3270 Uncharacterized conserved protein Cluster-8309.50596 BF_2 61.28 0.62 4430 642928531 XP_008195362.1 3020 0.0e+00 PREDICTED: transient receptor potential channel pyrexia [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 1952 5.3e-217 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF13606//PF07992//PF01266//PF00023//PF02254//PF00520 Ankyrin repeat//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Ankyrin repeat//TrkA-N domain//Ion transport protein GO:0055085//GO:0006813//GO:0055114//GO:0006811 transmembrane transport//potassium ion transport//oxidation-reduction process//ion transport GO:0016491//GO:0005515//GO:0005216 oxidoreductase activity//protein binding//ion channel activity GO:0016020 membrane KOG4177 Ankyrin Cluster-8309.50599 BF_2 84.73 0.86 4419 91079074 XP_975225.1 987 1.0e-103 PREDICTED: ras-related protein Rab-10 [Tribolium castaneum]>gi|270003655|gb|EFA00103.1| hypothetical protein TcasGA2_TC002919 [Tribolium castaneum] 642916371 XM_970132.3 262 4.5483e-132 PREDICTED: Tribolium castaneum ras-related protein Rab-10 (LOC664117), mRNA K07903 RAB10 Ras-related protein Rab-10 http://www.genome.jp/dbget-bin/www_bget?ko:K07903 P22127 793 1.3e-82 Ras-related protein Rab-10 OS=Diplobatis ommata PE=2 SV=1 PF01442//PF08477//PF04111//PF00025//PF16716//PF01496//PF04344//PF15898//PF00071//PF02601 Apolipoprotein A1/A4/E domain//Ras of Complex, Roc, domain of DAPkinase//Autophagy protein Apg6//ADP-ribosylation factor family//Bone marrow stromal antigen 2//V-type ATPase 116kDa subunit family//Chemotaxis phosphatase, CheZ//cGMP-dependent protein kinase interacting domain//Ras family//Exonuclease VII, large subunit GO:0042157//GO:0051607//GO:0006869//GO:0015991//GO:0007264//GO:0006308//GO:0050920//GO:0006914//GO:0015992//GO:0015031 lipoprotein metabolic process//defense response to virus//lipid transport//ATP hydrolysis coupled proton transport//small GTPase mediated signal transduction//DNA catabolic process//regulation of chemotaxis//autophagy//proton transport//protein transport GO:0003824//GO:0008289//GO:0008855//GO:0005525//GO:0019901//GO:0015078 catalytic activity//lipid binding//exodeoxyribonuclease VII activity//GTP binding//protein kinase binding//hydrogen ion transmembrane transporter activity GO:0005576//GO:0033179//GO:0009318//GO:0009288 extracellular region//proton-transporting V-type ATPase, V0 domain//exodeoxyribonuclease VII complex//bacterial-type flagellum KOG0078 GTP-binding protein SEC4, small G protein superfamily, and related Ras family GTP-binding proteins Cluster-8309.50600 BF_2 17.75 3.69 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50601 BF_2 91.00 2.81 1642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50603 BF_2 38.70 1.86 1157 642932044 XP_008196835.1 430 1.0e-39 PREDICTED: uncharacterized protein LOC103313971 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50607 BF_2 15.03 0.78 1090 91079146 XP_966535.1 240 1.0e-17 PREDICTED: ankyrin repeat domain-containing protein 49 [Tribolium castaneum]>gi|270004231|gb|EFA00679.1| hypothetical protein TcasGA2_TC003556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VE42 153 5.3e-09 Ankyrin repeat domain-containing protein 49 OS=Mus musculus GN=Ankrd49 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50608 BF_2 460.88 2.73 7344 642937185 XP_008198729.1 2693 2.6e-301 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 3.94939e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2250 2.5e-251 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF00856//PF11744//PF05192//PF00023//PF05033//PF00995//PF13606 SET domain//Aluminium activated malate transporter//MutS domain III//Ankyrin repeat//Pre-SET motif//Sec1 family//Ankyrin repeat GO:0016192//GO:0034968//GO:0015743//GO:0006904//GO:0006298//GO:0006554//GO:0006479 vesicle-mediated transport//histone lysine methylation//malate transport//vesicle docking involved in exocytosis//mismatch repair//lysine catabolic process//protein methylation GO:0005515//GO:0018024//GO:0005524//GO:0030983//GO:0008270 protein binding//histone-lysine N-methyltransferase activity//ATP binding//mismatched DNA binding//zinc ion binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.5061 BF_2 13.00 0.93 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50610 BF_2 231.55 6.76 1721 189237479 XP_970444.2 1590 4.8e-174 PREDICTED: golgi-associated PDZ and coiled-coil motif-containing protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH60 759 4.5e-79 Golgi-associated PDZ and coiled-coil motif-containing protein OS=Mus musculus GN=Gopc PE=1 SV=1 PF04871//PF05837//PF06156//PF00595 Uso1 / p115 like vesicle tethering protein, C terminal region//Centromere protein H (CENP-H)//Protein of unknown function (DUF972)//PDZ domain (Also known as DHR or GLGF) GO:0051382//GO:0006886//GO:0006260//GO:0015031 kinetochore assembly//intracellular protein transport//DNA replication//protein transport GO:0005515//GO:0008565 protein binding//protein transporter activity GO:0016020//GO:0000776//GO:0005737 membrane//kinetochore//cytoplasm -- -- Cluster-8309.50612 BF_2 28.22 0.33 3864 642911213 XP_008199622.1 1038 1.1e-109 PREDICTED: FCH domain only protein 2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UQN2 622 7.7e-63 F-BAR domain only protein 2 OS=Mus musculus GN=Fcho2 PE=1 SV=1 PF02662//PF01442//PF02050//PF13326 Methyl-viologen-reducing hydrogenase, delta subunit//Apolipoprotein A1/A4/E domain//Flagellar FliJ protein//Photosystem II Pbs27 GO:0055114//GO:0010207//GO:0071973//GO:0006869//GO:0006935//GO:0042157//GO:0015948 oxidation-reduction process//photosystem II assembly//bacterial-type flagellum-dependent cell motility//lipid transport//chemotaxis//lipoprotein metabolic process//methanogenesis GO:0003774//GO:0008289 motor activity//lipid binding GO:0016020//GO:0009288//GO:0005576 membrane//bacterial-type flagellum//extracellular region KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.50613 BF_2 65.39 1.37 2284 642923805 XP_008193890.1 1839 8.5e-203 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 4.5e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.50619 BF_2 126.95 1.72 3378 91077060 XP_968584.1 3353 0.0e+00 PREDICTED: TBC domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270001739|gb|EEZ98186.1| hypothetical protein TcasGA2_TC000615 [Tribolium castaneum] -- -- -- -- -- K17544 TBCK TBC domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17544 Q8TEA7 1806 3.5e-200 TBC domain-containing protein kinase-like protein OS=Homo sapiens GN=TBCK PE=1 SV=4 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding GO:0005622 intracellular KOG1093 Predicted protein kinase (contains TBC and RHOD domains) Cluster-8309.50620 BF_2 129.91 2.52 2443 270012313 EFA08761.1 390 9.5e-35 hypothetical protein TcasGA2_TC006440 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q93373 201 3.2e-14 Leucine-rich repeat-containing protein let-4 OS=Caenorhabditis elegans GN=let-4 PE=2 SV=2 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.50625 BF_2 674.23 3.16 9216 270010529 EFA06977.1 4691 0.0e+00 hypothetical protein TcasGA2_TC009937 [Tribolium castaneum] 642929421 XM_008197611.1 179 1.31275e-85 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X1, mRNA -- -- -- -- Q9UIF8 496 7.5e-48 Bromodomain adjacent to zinc finger domain protein 2B OS=Homo sapiens GN=BAZ2B PE=1 SV=3 PF01429//PF01221//PF00439//PF00130//PF08926//PF04574//PF06638//PF00628//PF16866 Methyl-CpG binding domain//Dynein light chain type 1//Bromodomain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Domain of unknown function (DUF1908)//Protein of unknown function (DUF592)//Strabismus protein//PHD-finger//PHD-finger GO:0006468//GO:0009069//GO:0035556//GO:0007017//GO:0006355//GO:0016310//GO:0006476//GO:0007275//GO:0006342//GO:0006807 protein phosphorylation//serine family amino acid metabolic process//intracellular signal transduction//microtubule-based process//regulation of transcription, DNA-templated//phosphorylation//protein deacetylation//multicellular organismal development//chromatin silencing//nitrogen compound metabolic process GO:0017136//GO:0016811//GO:0005524//GO:0004674//GO:0008270//GO:0005515//GO:0051287//GO:0003677//GO:0000287 NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//ATP binding//protein serine/threonine kinase activity//zinc ion binding//protein binding//NAD binding//DNA binding//magnesium ion binding GO:0005875//GO:0016021//GO:0005634//GO:0000118 microtubule associated complex//integral component of membrane//nucleus//histone deacetylase complex KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.50626 BF_2 532.07 13.04 1994 332374338 AEE62310.1 903 2.5e-94 unknown [Dendroctonus ponderosae] 759034475 XM_011335706.1 148 4.7918e-69 PREDICTED: Cerapachys biroi ADP-ribosylation factor-like protein 5B (LOC105277374), mRNA K07950 ARL5B ADP-ribosylation factor-like protein 5B http://www.genome.jp/dbget-bin/www_bget?ko:K07950 Q2KJ96 746 1.7e-77 ADP-ribosylation factor-like protein 5A OS=Bos taurus GN=ARL5A PE=2 SV=1 PF00071//PF04670//PF00503//PF01926//PF08477//PF03661//PF02421//PF00025//PF05843 Ras family//Gtr1/RagA G protein conserved region//G-protein alpha subunit//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Uncharacterised protein family (UPF0121)//Ferrous iron transport protein B//ADP-ribosylation factor family//Suppressor of forked protein (Suf) GO:0007186//GO:0007264//GO:0015684//GO:0007165//GO:0006397 G-protein coupled receptor signaling pathway//small GTPase mediated signal transduction//ferrous iron transport//signal transduction//mRNA processing GO:0005525//GO:0019001//GO:0004871//GO:0015093//GO:0031683//GO:0003924 GTP binding//guanyl nucleotide binding//signal transducer activity//ferrous iron transmembrane transporter activity//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.50627 BF_2 14.95 0.32 2247 91087535 XP_970133.1 321 8.7e-27 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] -- -- -- -- -- K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 189 7.3e-13 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 -- -- GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.50628 BF_2 86.99 9.38 675 91087535 XP_970133.1 629 5.1e-63 PREDICTED: DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Tribolium castaneum]>gi|270009448|gb|EFA05896.1| hypothetical protein TcasGA2_TC008708 [Tribolium castaneum] 642930219 XM_965040.2 161 9.30676e-77 PREDICTED: Tribolium castaneum DNA-directed RNA polymerases I, II, and III subunit RPABC3 (LOC658676), mRNA K03016 RPB8, POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03016 P52434 440 1.7e-42 DNA-directed RNA polymerases I, II, and III subunit RPABC3 OS=Homo sapiens GN=POLR2H PE=1 SV=4 PF03870 RNA polymerase Rpb8 GO:0006351 transcription, DNA-templated -- -- -- -- KOG3400 RNA polymerase subunit 8 Cluster-8309.50630 BF_2 37.61 0.65 2709 91088147 XP_971356.1 1157 1.2e-123 PREDICTED: platelet-activating factor acetylhydrolase [Tribolium castaneum]>gi|270012120|gb|EFA08568.1| hypothetical protein TcasGA2_TC006223 [Tribolium castaneum] -- -- -- -- -- K05961 dnk deoxynucleoside kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05961 P70683 520 3.6e-51 Platelet-activating factor acetylhydrolase OS=Cavia porcellus GN=PLA2G7 PE=2 SV=1 PF03403//PF01121//PF02367//PF01738//PF00005 Platelet-activating factor acetylhydrolase, isoform II//Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Dienelactone hydrolase family//ABC transporter GO:0046486//GO:0015937//GO:0016042//GO:0002949//GO:0015940 glycerolipid metabolic process//coenzyme A biosynthetic process//lipid catabolic process//tRNA threonylcarbamoyladenosine modification//pantothenate biosynthetic process GO:0004140//GO:0016887//GO:0016787//GO:0003847//GO:0005524 dephospho-CoA kinase activity//ATPase activity//hydrolase activity//1-alkyl-2-acetylglycerophosphocholine esterase activity//ATP binding GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG4235 Mitochondrial thymidine kinase 2/deoxyguanosine kinase Cluster-8309.50631 BF_2 90.88 0.43 9206 642937449 XP_008198840.1 454 1.4e-41 PREDICTED: protein tramtrack, beta isoform-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07127//PF00628//PF00042 Late nodulin protein//PHD-finger//Globin GO:0009878 nodule morphogenesis GO:0019825//GO:0020037//GO:0046872//GO:0005515 oxygen binding//heme binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.50636 BF_2 416.00 5.54 3431 546674943 ERL86220.1 2362 2.9e-263 hypothetical protein D910_03631, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6ZVD7 317 1.6e-27 Storkhead-box protein 1 OS=Homo sapiens GN=STOX1 PE=1 SV=2 PF02153 Prephenate dehydrogenase GO:0006571//GO:0055114//GO:0000162//GO:0009094 tyrosine biosynthetic process//oxidation-reduction process//tryptophan biosynthetic process//L-phenylalanine biosynthetic process GO:0008977//GO:0004665 prephenate dehydrogenase activity//prephenate dehydrogenase (NADP+) activity -- -- -- -- Cluster-8309.50637 BF_2 212.00 1.68 5569 91080879 XP_972622.1 4552 0.0e+00 PREDICTED: coronin-7 isoform X2 [Tribolium castaneum] -- -- -- -- -- K18619 CORO7 coronin-7 http://www.genome.jp/dbget-bin/www_bget?ko:K18619 Q9D2V7 1118 3.4e-120 Coronin-7 OS=Mus musculus GN=Coro7 PE=2 SV=2 PF04053//PF00400 Coatomer WD associated region//WD domain, G-beta repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG0303 Actin-binding protein Coronin, contains WD40 repeats Cluster-8309.50639 BF_2 130.75 6.79 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50645 BF_2 380.39 2.89 5790 642920442 XP_008192352.1 1913 5.6e-211 PREDICTED: interference hedgehog-like isoform X6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 849 5.5e-89 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF13895//PF00041//PF02480//PF16656 Immunoglobulin domain//Fibronectin type III domain//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0016020 membrane -- -- Cluster-8309.50646 BF_2 2.07 0.39 507 642915775 XP_008200074.1 399 1.8e-36 PREDICTED: translocating chain-associated membrane protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14010 TRAM1 translocating chain-associated membrane protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14010 Q01685 170 2.6e-11 Translocating chain-associated membrane protein 1 OS=Canis familiaris GN=TRAM1 PE=1 SV=2 PF03798 TLC domain -- -- -- -- GO:0016021 integral component of membrane KOG1608 Protein transporter of the TRAM (translocating chain-associating membrane) superfamily Cluster-8309.50652 BF_2 28.40 0.54 2486 780089478 XP_011673857.1 145 2.5e-06 PREDICTED: uncharacterized protein LOC105442899 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10104//PF02935 Di-sulfide bridge nucleocytoplasmic transport domain//Cytochrome c oxidase subunit VIIc GO:0006406//GO:0006611//GO:0006998//GO:0006123//GO:0015992 mRNA export from nucleus//protein export from nucleus//nuclear envelope organization//mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0031965//GO:0045277 nuclear membrane//respiratory chain complex IV -- -- Cluster-8309.50653 BF_2 173.93 7.60 1244 478250793 ENN71285.1 367 2.2e-32 hypothetical protein YQE_12210, partial [Dendroctonus ponderosae] -- -- -- -- -- K17402 MRPS23 small subunit ribosomal protein S23 http://www.genome.jp/dbget-bin/www_bget?ko:K17402 Q2NL27 174 2.2e-11 28S ribosomal protein S23, mitochondrial OS=Bos taurus GN=MRPS23 PE=1 SV=1 PF10484//PF13741 Mitochondrial ribosomal protein S23//Mitochondrial ribosomal protein S25 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005763//GO:0005840 mitochondrial small ribosomal subunit//ribosome -- -- Cluster-8309.50654 BF_2 173.26 7.75 1222 546673007 ERL84693.1 367 2.2e-32 hypothetical protein D910_02120 [Dendroctonus ponderosae] -- -- -- -- -- K17402 MRPS23 small subunit ribosomal protein S23 http://www.genome.jp/dbget-bin/www_bget?ko:K17402 Q2NL27 174 2.2e-11 28S ribosomal protein S23, mitochondrial OS=Bos taurus GN=MRPS23 PE=1 SV=1 PF10484//PF13741 Mitochondrial ribosomal protein S23//Mitochondrial ribosomal protein S25 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005763 ribosome//mitochondrial small ribosomal subunit -- -- Cluster-8309.50657 BF_2 253.30 2.16 5197 283046724 NP_001164308.1 351 6.7e-30 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 275 1.8e-22 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF13606//PF09153//PF04988//PF00096//PF00520//PF07535 Ankyrin repeat//Domain of unknown function (DUF1938)//A-kinase anchoring protein 95 (AKAP95)//Zinc finger, C2H2 type//Ion transport protein//DBF zinc finger GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0003676//GO:0008270//GO:0005216//GO:0046872//GO:0003677//GO:0005515 nucleic acid binding//zinc ion binding//ion channel activity//metal ion binding//DNA binding//protein binding GO:0016020//GO:0005737//GO:0005634 membrane//cytoplasm//nucleus -- -- Cluster-8309.50658 BF_2 83.16 0.66 5551 283046724 NP_001164308.1 351 7.2e-30 painless [Tribolium castaneum]>gi|642919098|ref|XP_008191735.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919100|ref|XP_008191736.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|642919102|ref|XP_008191737.1| PREDICTED: painless isoform X1 [Tribolium castaneum]>gi|270006388|gb|EFA02836.1| painless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0Y6 275 1.9e-22 Transient receptor potential cation channel protein painless OS=Drosophila melanogaster GN=pain PE=1 SV=1 PF13606//PF07535//PF00520//PF00096//PF09153//PF04988 Ankyrin repeat//DBF zinc finger//Ion transport protein//Zinc finger, C2H2 type//Domain of unknown function (DUF1938)//A-kinase anchoring protein 95 (AKAP95) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0003677//GO:0005515//GO:0003676//GO:0005216//GO:0008270//GO:0046872 DNA binding//protein binding//nucleic acid binding//ion channel activity//zinc ion binding//metal ion binding GO:0005634//GO:0016020//GO:0005737 nucleus//membrane//cytoplasm -- -- Cluster-8309.50662 BF_2 106.01 3.36 1606 478257137 ENN77300.1 376 2.6e-33 hypothetical protein YQE_06126, partial [Dendroctonus ponderosae]>gi|546681456|gb|ERL91553.1| hypothetical protein D910_08883 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50663 BF_2 24.20 0.52 2234 91077894 XP_973141.1 1014 3.8e-107 PREDICTED: protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha [Tribolium castaneum]>gi|270001465|gb|EEZ97912.1| hypothetical protein TcasGA2_TC000297 [Tribolium castaneum] 704568790 XM_010186488.1 35 3.52406e-06 PREDICTED: Mesitornis unicolor farnesyltransferase, CAAX box, alpha (FNTA), partial mRNA K05955 FNTA protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05955 P29702 623 3.4e-63 Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha OS=Bos taurus GN=FNTA PE=2 SV=2 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- KOG0530 Protein farnesyltransferase, alpha subunit/protein geranylgeranyltransferase type I, alpha subunit Cluster-8309.50666 BF_2 206.46 2.87 3295 642934163 XP_008199633.1 735 1.3e-74 PREDICTED: uncharacterized protein LOC657295 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q14135 151 2.7e-08 Transcription cofactor vestigial-like protein 4 OS=Homo sapiens GN=VGLL4 PE=1 SV=4 PF07545//PF15245 Vestigial/Tondu family//Transcription cofactor vestigial-like protein 4 GO:0006355 regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.50670 BF_2 78.68 2.00 1931 642920402 XP_008192333.1 464 2.0e-43 PREDICTED: uncharacterized protein LOC664268 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50671 BF_2 212.40 2.69 3585 546676365 ERL87392.1 1940 2.6e-214 hypothetical protein D910_04787, partial [Dendroctonus ponderosae] 828210619 XM_004208630.2 127 4.09515e-57 PREDICTED: Hydra vulgaris SNF-related serine/threonine-protein kinase-like (LOC100200107), mRNA K08802 SNRK SNF related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08802 Q9NRH2 1339 5.2e-146 SNF-related serine/threonine-protein kinase OS=Homo sapiens GN=SNRK PE=1 SV=2 PF09573//PF06293//PF00069//PF07714 TaqI restriction endonuclease//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006308//GO:0009307//GO:0006468 DNA catabolic process//DNA restriction-modification system//protein phosphorylation GO:0004672//GO:0016773//GO:0009036//GO:0003677//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//Type II site-specific deoxyribonuclease activity//DNA binding//ATP binding GO:0016020//GO:0009359 membrane//Type II site-specific deoxyribonuclease complex KOG4717 Serine/threonine protein kinase Cluster-8309.50673 BF_2 87.42 0.98 4011 91075990 XP_970704.1 2425 1.7e-270 PREDICTED: synaptojanin-1 isoform X1 [Tribolium castaneum]>gi|270014666|gb|EFA11114.1| hypothetical protein TcasGA2_TC004712 [Tribolium castaneum] 642910454 XM_008192523.1 287 5.22385e-146 PREDICTED: Tribolium castaneum synaptojanin-1 (LOC659292), transcript variant X2, mRNA K01099 E3.1.3.36 phosphatidylinositol-bisphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01099 O43426 1532 2.4e-168 Synaptojanin-1 OS=Homo sapiens GN=SYNJ1 PE=1 SV=2 -- -- GO:0046854 phosphatidylinositol phosphorylation GO:0042578//GO:0000166 phosphoric ester hydrolase activity//nucleotide binding -- -- KOG0566 Inositol-1,4,5-triphosphate 5-phosphatase (synaptojanin), INP51/INP52/INP53 family Cluster-8309.50674 BF_2 936.54 8.14 5100 270012402 EFA08850.1 3240 0.0e+00 hypothetical protein TcasGA2_TC006551 [Tribolium castaneum] 642932661 XM_008198715.1 84 4.67978e-33 PREDICTED: Tribolium castaneum inactive rhomboid protein 1 (LOC658816), mRNA -- -- -- -- Q76NQ1 1377 2.9e-150 Inactive rhomboid protein 1 OS=Drosophila melanogaster GN=rho-5 PE=2 SV=1 PF01694 Rhomboid family -- -- GO:0004252 serine-type endopeptidase activity GO:0016021 integral component of membrane KOG2290 Rhomboid family proteins Cluster-8309.50675 BF_2 103.89 0.85 5397 642919693 XP_008192024.1 793 3.9e-81 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0T5 372 1.1e-33 Transient receptor potential channel pyrexia OS=Drosophila melanogaster GN=pyx PE=2 SV=2 PF10716//PF00520 NADH dehydrogenase transmembrane subunit//Ion transport protein GO:0055114//GO:0006811//GO:0006118//GO:0055085 oxidation-reduction process//ion transport//obsolete electron transport//transmembrane transport GO:0016655//GO:0005216 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//ion channel activity GO:0016020 membrane KOG0510 Ankyrin repeat protein Cluster-8309.50678 BF_2 43.35 1.00 2093 478254477 ENN74726.1 1349 5.1e-146 hypothetical protein YQE_08693, partial [Dendroctonus ponderosae]>gi|546685047|gb|ERL94601.1| hypothetical protein D910_11878 [Dendroctonus ponderosae] -- -- -- -- -- K13205 AAR2, C20orf4 A1 cistron-splicing factor AAR2 http://www.genome.jp/dbget-bin/www_bget?ko:K13205 Q08DJ7 779 2.6e-81 Protein AAR2 homolog OS=Bos taurus GN=AAR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3937 mRNA splicing factor Cluster-8309.50679 BF_2 5.70 0.82 578 642926187 XP_008194822.1 484 2.8e-46 PREDICTED: deleted in azoospermia-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24207 333 3.8e-30 Protein boule OS=Drosophila melanogaster GN=bol PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8309.50682 BF_2 53.83 1.03 2476 642939406 XP_008193285.1 335 2.3e-28 PREDICTED: uncharacterized protein LOC661130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5M8X6 130 5.6e-06 Collectin-10 OS=Xenopus tropicalis GN=colec10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50685 BF_2 334.86 6.80 2348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50688 BF_2 2.00 3.26 294 478253101 ENN73474.1 247 4.3e-19 hypothetical protein YQE_09899, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02161 Progesterone receptor GO:0006355//GO:0007165//GO:0043401 regulation of transcription, DNA-templated//signal transduction//steroid hormone mediated signaling pathway GO:0003707//GO:0005496//GO:0003677 steroid hormone receptor activity//steroid binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.50691 BF_2 1.00 0.99 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00322 Endothelin family GO:0019229 regulation of vasoconstriction -- -- GO:0005576 extracellular region -- -- Cluster-8309.50693 BF_2 4.00 2.65 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50695 BF_2 31.00 2.14 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50697 BF_2 3.22 0.37 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50699 BF_2 33.78 4.44 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50700 BF_2 129.16 1.06 5367 478255001 ENN75234.1 1692 2.2e-185 hypothetical protein YQE_08244, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1080 8.4e-116 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF06414//PF01637//PF03193//PF00005//PF01926//PF13304//PF00664//PF00437 Zeta toxin//Archaeal ATPase//Protein of unknown function, DUF258//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0055085//GO:0006810 transmembrane transport//transport GO:0016887//GO:0016301//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//kinase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50701 BF_2 70.45 0.71 4414 642938610 XP_008199864.1 2111 4.7e-234 PREDICTED: protein trachealess [Tribolium castaneum] 820805579 KP147944.1 547 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1103 1.5e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00010//PF04551//PF08447//PF00989 Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold//PAS fold GO:0055114//GO:0016114//GO:0006355 oxidation-reduction process//terpenoid biosynthetic process//regulation of transcription, DNA-templated GO:0005515//GO:0046429//GO:0046983 protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity//protein dimerization activity -- -- -- -- Cluster-8309.50704 BF_2 81.46 2.24 1805 546682401 ERL92343.1 1126 3.2e-120 hypothetical protein D910_09660 [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 735 2.9e-76 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.50706 BF_2 32.16 0.99 1647 642915964 XP_008190829.1 974 1.2e-102 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 1.0e-27 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50708 BF_2 232.70 6.76 1727 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50710 BF_2 34.69 1.20 1493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.50714 BF_2 19.27 0.40 2326 642915964 XP_008190829.1 611 2.1e-60 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 284 7.3e-24 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50715 BF_2 18.06 0.44 2018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50716 BF_2 103.42 2.37 2110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50718 BF_2 385.97 3.86 4465 91082023 XP_970243.1 884 9.1e-92 PREDICTED: 39S ribosomal protein L47, mitochondrial [Tribolium castaneum]>gi|270007306|gb|EFA03754.1| hypothetical protein TcasGA2_TC013863 [Tribolium castaneum] -- -- -- -- -- K17428 MRPL47, NCM1 large subunit ribosomal protein L47 http://www.genome.jp/dbget-bin/www_bget?ko:K17428 Q9HD33 443 5.1e-42 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0005761 ribosome//mitochondrial ribosome KOG3331 Mitochondrial/chloroplast ribosomal protein L4/L29 Cluster-8309.50719 BF_2 92.03 0.87 4722 91082023 XP_970243.1 884 9.6e-92 PREDICTED: 39S ribosomal protein L47, mitochondrial [Tribolium castaneum]>gi|270007306|gb|EFA03754.1| hypothetical protein TcasGA2_TC013863 [Tribolium castaneum] -- -- -- -- -- K17428 MRPL47, NCM1 large subunit ribosomal protein L47 http://www.genome.jp/dbget-bin/www_bget?ko:K17428 Q9HD33 443 5.4e-42 39S ribosomal protein L47, mitochondrial OS=Homo sapiens GN=MRPL47 PE=1 SV=2 PF06984 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005761//GO:0005840 mitochondrial ribosome//ribosome KOG3331 Mitochondrial/chloroplast ribosomal protein L4/L29 Cluster-8309.50720 BF_2 648.91 6.28 4607 91081241 XP_975643.1 2015 6.7e-223 PREDICTED: interference hedgehog-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4JEF2 851 2.6e-89 Interference hedgehog OS=Drosophila grimshawi GN=iHog PE=3 SV=1 PF02480//PF16656//PF00041//PF13895 Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.50721 BF_2 5.18 0.32 967 270010513 EFA06961.1 607 2.6e-60 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03568 Peptidase family C50 GO:0006508 proteolysis GO:0008233 peptidase activity GO:0005634 nucleus -- -- Cluster-8309.50723 BF_2 22.41 0.32 3261 270003759 EFA00207.1 1136 4.0e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 3.88265e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.1e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.50724 BF_2 29.00 4.16 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50727 BF_2 4.00 0.43 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50730 BF_2 216.33 2.29 4245 642923551 XP_008193555.1 837 2.4e-86 PREDICTED: Golgi integral membrane protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 186 3.1e-12 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 PF01940//PF02513//PF04111//PF02566//PF05090 Integral membrane protein DUF92//Spin/Ssty Family//Autophagy protein Apg6//OsmC-like protein//Vitamin K-dependent gamma-carboxylase GO:0006914//GO:0007276//GO:0017187//GO:0006979 autophagy//gamete generation//peptidyl-glutamic acid carboxylation//response to oxidative stress GO:0008488 gamma-glutamyl carboxylase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50731 BF_2 1.00 0.57 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50733 BF_2 14.00 0.99 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50734 BF_2 172.64 2.36 3345 91088343 XP_971105.1 804 1.3e-82 PREDICTED: L-xylulose reductase [Tribolium castaneum]>gi|270011784|gb|EFA08232.1| hypothetical protein TcasGA2_TC005860 [Tribolium castaneum] -- -- -- -- -- K03331 DCXR L-xylulose reductase http://www.genome.jp/dbget-bin/www_bget?ko:K03331 Q1JP75 582 2.9e-58 L-xylulose reductase OS=Bos taurus GN=DCXR PE=2 SV=1 PF00106//PF01370//PF02558//PF02254//PF02826//PF02882//PF12242 short chain dehydrogenase//NAD dependent epimerase/dehydratase family//Ketopantoate reductase PanE/ApbA//TrkA-N domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0055114//GO:0006813//GO:0009396//GO:0046487//GO:0008152//GO:0015940 oxidation-reduction process//potassium ion transport//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//metabolic process//pantothenate biosynthetic process GO:0008677//GO:0051287//GO:0016491//GO:0004488//GO:0003824//GO:0050662 2-dehydropantoate 2-reductase activity//NAD binding//oxidoreductase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//catalytic activity//coenzyme binding -- -- KOG1207 Diacetyl reductase/L-xylulose reductase Cluster-8309.50736 BF_2 2.00 1.31 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50738 BF_2 120.00 2.12 2660 642914962 XP_008190460.1 841 5.2e-87 PREDICTED: ribosomal RNA-processing protein 8 [Tribolium castaneum]>gi|270001380|gb|EEZ97827.1| hypothetical protein TcasGA2_TC000195 [Tribolium castaneum] -- -- -- -- -- K14850 RRP8 ribosomal RNA-processing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K14850 Q9DB85 599 2.5e-60 Ribosomal RNA-processing protein 8 OS=Mus musculus GN=Rrp8 PE=1 SV=1 PF10391//PF05148//PF08241//PF05175 Fingers domain of DNA polymerase lambda//Hypothetical methyltransferase//Methyltransferase domain//Methyltransferase small domain GO:0008152 metabolic process GO:0034061//GO:0008168//GO:0003677 DNA polymerase activity//methyltransferase activity//DNA binding GO:0005634 nucleus KOG3045 Predicted RNA methylase involved in rRNA processing Cluster-8309.50739 BF_2 121.00 3.83 1608 91077596 XP_973387.1 648 7.6e-65 PREDICTED: forkhead-associated domain-containing protein 1 [Tribolium castaneum]>gi|270001561|gb|EEZ98008.1| hypothetical protein TcasGA2_TC000407 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16331//PF00992//PF16326//PF05531//PF00170//PF13851//PF06005//PF01166//PF04513//PF03999//PF07716//PF00038//PF02183 TolA binding protein trimerisation//Troponin//ABC transporter C-terminal domain//Nucleopolyhedrovirus P10 protein//bZIP transcription factor//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF904)//TSC-22/dip/bun family//Baculovirus polyhedron envelope protein, PEP, C terminus//Microtubule associated protein (MAP65/ASE1 family)//Basic region leucine zipper//Intermediate filament protein//Homeobox associated leucine zipper GO:0006355//GO:0070206//GO:0000226//GO:0043093//GO:0000917//GO:0048870//GO:0000910 regulation of transcription, DNA-templated//protein trimerization//microtubule cytoskeleton organization//FtsZ-dependent cytokinesis//barrier septum assembly//cell motility//cytokinesis GO:0003700//GO:0043565//GO:0005198//GO:0008017//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//structural molecule activity//microtubule binding//DNA binding GO:0005737//GO:0005882//GO:0045298//GO:0019028//GO:0031514//GO:0005861//GO:0019031//GO:0005667 cytoplasm//intermediate filament//tubulin complex//viral capsid//motile cilium//troponin complex//viral envelope//transcription factor complex -- -- Cluster-8309.50740 BF_2 61.27 0.56 4862 91093829 XP_969227.1 1839 1.8e-202 PREDICTED: transmembrane protein 161B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C2L6 1009 1.3e-107 Transmembrane protein 161B OS=Mus musculus GN=Tmem161b PE=2 SV=1 PF04632//PF10018//PF01008//PF00336 Fusaric acid resistance protein family//Vitamin-D-receptor interacting Mediator subunit 4//Initiation factor 2 subunit family//DNA polymerase (viral) C-terminal domain GO:0006357//GO:0051252//GO:0006810//GO:0044237 regulation of transcription from RNA polymerase II promoter//regulation of RNA metabolic process//transport//cellular metabolic process GO:0004523//GO:0001104 RNA-DNA hybrid ribonuclease activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0005886 mediator complex//plasma membrane KOG1468 Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2) Cluster-8309.50741 BF_2 200.34 0.98 8805 91086935 XP_972534.1 3985 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2479 8.2e-278 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF13958//PF01926//PF13304//PF00664//PF14719//PF00437//PF03193//PF00005//PF05209//PF02724//PF00640//PF00931 Toxin ToxN, type III toxin-antitoxin system//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//Phosphotyrosine interaction domain (PTB/PID)//Type II/IV secretion system protein//Protein of unknown function, DUF258//ABC transporter//Septum formation inhibitor MinC, N-terminal domain//CDC45-like protein//Phosphotyrosine interaction domain (PTB/PID)//NB-ARC domain GO:0055085//GO:0051302//GO:0006810//GO:0006270//GO:0009987//GO:0051252 transmembrane transport//regulation of cell division//transport//DNA replication initiation//cellular process//regulation of RNA metabolic process GO:0005524//GO:0004521//GO:0003924//GO:0016887//GO:0000166//GO:0042626//GO:0003723//GO:0005515//GO:0043531//GO:0005525 ATP binding//endoribonuclease activity//GTPase activity//ATPase activity//nucleotide binding//ATPase activity, coupled to transmembrane movement of substances//RNA binding//protein binding//ADP binding//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.50742 BF_2 518.68 5.70 4092 91086935 XP_972534.1 4084 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] 195484314 XM_002090606.1 45 1.79395e-11 Drosophila yakuba GE13220 (Dyak\GE13220), partial mRNA K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 2458 1.0e-275 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF13304//PF01926//PF00437//PF05209//PF00005//PF03193//PF02724//PF00931 ABC transporter transmembrane region//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein//Septum formation inhibitor MinC, N-terminal domain//ABC transporter//Protein of unknown function, DUF258//CDC45-like protein//NB-ARC domain GO:0009987//GO:0006270//GO:0006810//GO:0055085//GO:0051302 cellular process//DNA replication initiation//transport//transmembrane transport//regulation of cell division GO:0042626//GO:0000166//GO:0005525//GO:0016887//GO:0043531//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//nucleotide binding//GTP binding//ATPase activity//ADP binding//GTPase activity//ATP binding GO:0016021 integral component of membrane -- -- Cluster-8309.50745 BF_2 39.79 0.86 2212 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50747 BF_2 289.38 0.70 17491 642913486 XP_008201031.1 6210 0.0e+00 PREDICTED: histone-lysine N-methyltransferase 2C-like isoform X2 [Tribolium castaneum] 807039419 XM_004534701.2 145 1.98434e-66 PREDICTED: Ceratitis capitata histone-lysine N-methyltransferase trr (LOC101450744), mRNA K09188 MLL3 histone-lysine N-methyltransferase MLL3 http://www.genome.jp/dbget-bin/www_bget?ko:K09188 Q8IRW8 1972 1.0e-218 Histone-lysine N-methyltransferase trr OS=Drosophila melanogaster GN=trr PE=1 SV=2 PF07155//PF00628//PF05964//PF00856//PF05965//PF08052 ECF-type riboflavin transporter, S component//PHD-finger//F/Y-rich N-terminus//SET domain//F/Y rich C-terminus//PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process GO:0005515 protein binding GO:0016020//GO:0005634 membrane//nucleus KOG4443 Putative transcription factor HALR/MLL3, involved in embryonic development Cluster-8309.50748 BF_2 56.70 0.46 5396 546680337 ERL90623.1 1560 4.5e-170 hypothetical protein D910_07970 [Dendroctonus ponderosae] -- -- -- -- -- K00272 DDO D-aspartate oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00272 Q99489 534 1.7e-52 D-aspartate oxidase OS=Homo sapiens GN=DDO PE=2 SV=1 PF02985//PF01266 HEAT repeat//FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0005515//GO:0016491 protein binding//oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.50749 BF_2 43.25 0.43 4468 642935794 XP_008198177.1 369 4.7e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00864//PF00335 ATP P2X receptor//Tetraspanin family GO:0007165//GO:0006812//GO:0098655//GO:0033198 signal transduction//cation transport//cation transmembrane transport//response to ATP GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0016021//GO:0005887 integral component of membrane//integral component of plasma membrane -- -- Cluster-8309.50750 BF_2 249.84 2.78 4049 91086367 XP_974595.1 889 2.2e-92 PREDICTED: ankyrin repeat family A protein 2-like [Tribolium castaneum] -- -- -- -- -- K13352 PEX11B peroxin-11B http://www.genome.jp/dbget-bin/www_bget?ko:K13352 Q9ULH0 194 3.5e-13 Kinase D-interacting substrate of 220 kDa OS=Homo sapiens GN=KIDINS220 PE=1 SV=3 PF05648//PF02932//PF00023//PF02931//PF13606 Peroxisomal biogenesis factor 11 (PEX11)//Neurotransmitter-gated ion-channel transmembrane region//Ankyrin repeat//Neurotransmitter-gated ion-channel ligand binding domain//Ankyrin repeat GO:0006811//GO:0016559//GO:0006810 ion transport//peroxisome fission//transport GO:0005230//GO:0005515 extracellular ligand-gated ion channel activity//protein binding GO:0016020//GO:0005779 membrane//integral component of peroxisomal membrane -- -- Cluster-8309.50751 BF_2 420.20 2.28 7986 91079606 XP_966371.1 1460 2.6e-158 PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|642917676|ref|XP_008191323.1| PREDICTED: proton-coupled amino acid transporter 4 [Tribolium castaneum]>gi|270003388|gb|EEZ99835.1| hypothetical protein TcasGA2_TC002616 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q924A5 585 3.1e-58 Proton-coupled amino acid transporter 1 OS=Rattus norvegicus GN=Slc36a1 PE=2 SV=1 PF14659//PF16588//PF01312 Phage integrase, N-terminal SAM-like domain//C2H2 zinc-finger//FlhB HrpN YscU SpaS Family GO:0015074//GO:0009306 DNA integration//protein secretion GO:0003676//GO:0003677//GO:0008270 nucleic acid binding//DNA binding//zinc ion binding GO:0016020 membrane KOG1304 Amino acid transporters Cluster-8309.50755 BF_2 59.99 0.98 2844 642935023 XP_008199910.1 1040 4.7e-110 PREDICTED: ester hydrolase C11orf54 homolog isoform X1 [Tribolium castaneum]>gi|270013012|gb|EFA09460.1| hypothetical protein TcasGA2_TC010676 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HJH3 644 1.6e-65 Ester hydrolase C11orf54 homolog OS=Bos taurus PE=2 SV=1 PF08925 Domain of Unknown Function (DUF1907) -- -- -- -- GO:0005634 nucleus KOG4059 Uncharacterized conserved protein Cluster-8309.50756 BF_2 125.38 1.89 3057 645020639 XP_008207241.1 204 4.4e-13 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01522 Polysaccharide deacetylase GO:0006807//GO:0005975 nitrogen compound metabolic process//carbohydrate metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- -- -- Cluster-8309.50757 BF_2 55.00 1.42 1909 642916317 XP_008190971.1 315 3.7e-26 PREDICTED: uncharacterized protein LOC103312340 [Tribolium castaneum]>gi|270004179|gb|EFA00627.1| hypothetical protein TcasGA2_TC003503 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01695//PF00004//PF06309//PF00005//PF03193//PF02562//PF00910//PF00931//PF08047 IstB-like ATP binding protein//ATPase family associated with various cellular activities (AAA)//Torsin//ABC transporter//Protein of unknown function, DUF258//PhoH-like protein//RNA helicase//NB-ARC domain//Histidine operon leader peptide GO:0000105 histidine biosynthetic process GO:0003724//GO:0016887//GO:0005525//GO:0003924//GO:0043531//GO:0003723//GO:0005524 RNA helicase activity//ATPase activity//GTP binding//GTPase activity//ADP binding//RNA binding//ATP binding -- -- -- -- Cluster-8309.50758 BF_2 269.93 4.64 2719 242015216 XP_002428268.1 1387 2.6e-150 cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis]>gi|212512842|gb|EEB15530.1| cAMP-dependent protein kinase catalytic subunit, putative [Pediculus humanus corporis] 558203653 XM_006132037.1 59 1.95783e-19 PREDICTED: Pelodiscus sinensis mitogen-activated protein kinase kinase 7 (MAP2K7), partial mRNA K04432 MAP2K3, MKK3 mitogen-activated protein kinase kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04432 O09110 1122 5.7e-121 Dual specificity mitogen-activated protein kinase kinase 3 OS=Mus musculus GN=Map2k3 PE=1 SV=2 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004672//GO:0004674 ATP binding//protein kinase activity//protein serine/threonine kinase activity -- -- KOG0984 Mitogen-activated protein kinase (MAPK) kinase MKK3/MKK6 Cluster-8309.50759 BF_2 161.05 2.16 3410 91077060 XP_968584.1 3353 0.0e+00 PREDICTED: TBC domain-containing protein kinase-like protein [Tribolium castaneum]>gi|270001739|gb|EEZ98186.1| hypothetical protein TcasGA2_TC000615 [Tribolium castaneum] -- -- -- -- -- K17544 TBCK TBC domain-containing protein kinase-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K17544 Q8TEA7 1806 3.5e-200 TBC domain-containing protein kinase-like protein OS=Homo sapiens GN=TBCK PE=1 SV=4 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity GO:0005622 intracellular KOG1093 Predicted protein kinase (contains TBC and RHOD domains) Cluster-8309.50762 BF_2 38.00 0.67 2657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50764 BF_2 2.00 0.45 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50766 BF_2 42.33 0.89 2278 91092284 XP_968475.1 1070 1.2e-113 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [Tribolium castaneum]>gi|270001209|gb|EEZ97656.1| hypothetical protein TcasGA2_TC016200 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q99943 486 2.7e-47 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Homo sapiens GN=AGPAT1 PE=1 SV=2 PF01553 Acyltransferase GO:0008152//GO:0042967//GO:0008654//GO:0046486 metabolic process//acyl-carrier-protein biosynthetic process//phospholipid biosynthetic process//glycerolipid metabolic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane KOG2848 1-acyl-sn-glycerol-3-phosphate acyltransferase Cluster-8309.50767 BF_2 1.00 15.15 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5077 BF_2 23.00 1.18 1102 270016830 EFA13276.1 530 2.5e-51 hypothetical protein TcasGA2_TC016027 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P27401 215 3.5e-16 Pro-Pol polyprotein OS=Simian foamy virus type 3 (strain LK3) GN=pol PE=3 SV=2 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.50771 BF_2 229.04 3.96 2708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50774 BF_2 308.82 4.51 3149 642939483 XP_966848.2 1017 2.4e-107 PREDICTED: transcription elongation factor B polypeptide 3 [Tribolium castaneum]>gi|642939485|ref|XP_008193753.1| PREDICTED: transcription elongation factor B polypeptide 3 [Tribolium castaneum]>gi|270016551|gb|EFA12997.1| hypothetical protein TcasGA2_TC001477 [Tribolium castaneum] -- -- -- -- -- K15076 TCEB3, ELOA transcription elongation factor B, polypeptide 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15076 Q9VCP0 606 4.5e-61 Transcription elongation factor B polypeptide 3 OS=Drosophila melanogaster GN=EloA PE=1 SV=1 PF08711//PF06881 TFIIS helical bundle-like domain//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006351//GO:0006355 transcription, DNA-templated//regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG2821 RNA polymerase II transcription elongation factor Elongin/SIII, subunit elongin A Cluster-8309.50778 BF_2 109.89 1.59 3185 91079722 XP_969695.1 2853 0.0e+00 PREDICTED: xenotropic and polytropic retrovirus receptor 1 [Tribolium castaneum]>gi|270003331|gb|EEZ99778.1| hypothetical protein TcasGA2_TC002557 [Tribolium castaneum] 827561892 XM_004932993.2 53 4.97404e-16 PREDICTED: Bombyx mori xenotropic and polytropic retrovirus receptor 1 (LOC101739894), mRNA -- -- -- -- Q9Z0U0 1878 1.5e-208 Xenotropic and polytropic retrovirus receptor 1 OS=Mus musculus GN=Xpr1 PE=1 SV=1 PF03124 EXS family -- -- -- -- GO:0016021 integral component of membrane KOG1162 Predicted small molecule transporter Cluster-8309.50781 BF_2 81.63 0.76 4773 91078484 XP_968508.1 435 1.1e-39 PREDICTED: uncharacterized protein C20orf24 homolog [Tribolium castaneum]>gi|270003855|gb|EFA00303.1| hypothetical protein TcasGA2_TC003138 [Tribolium castaneum] 766924181 XM_011495620.1 92 1.56336e-37 PREDICTED: Ceratosolen solmsi marchali uncharacterized protein C20orf24 homolog (LOC105359127), mRNA -- -- -- -- Q9CQT9 303 9.4e-26 Uncharacterized protein C20orf24 homolog OS=Mus musculus PE=2 SV=1 PF07062 Clc-like -- -- -- -- GO:0016021 integral component of membrane KOG3415 Putative Rab5-interacting protein Cluster-8309.50786 BF_2 20.00 0.31 2999 861621514 KMQ87532.1 318 2.6e-26 mariner mos1 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07552 Spore Coat Protein X and V domain GO:0030435 sporulation resulting in formation of a cellular spore -- -- GO:0031160 spore wall -- -- Cluster-8309.50788 BF_2 11.58 0.80 889 91080705 XP_975304.1 592 1.3e-58 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- K17353 TSPAN18 tetraspanin-18 http://www.genome.jp/dbget-bin/www_bget?ko:K17353 P27701 236 1.0e-18 CD82 antigen OS=Homo sapiens GN=CD82 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.50795 BF_2 10.00 1.27 616 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50796 BF_2 31.00 1.72 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50800 BF_2 23.28 0.33 3219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50802 BF_2 3.00 0.46 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50803 BF_2 192.29 15.78 797 91085321 XP_969715.1 722 9.8e-74 PREDICTED: lactoylglutathione lyase [Tribolium castaneum]>gi|270009130|gb|EFA05578.1| hypothetical protein TcasGA2_TC015771 [Tribolium castaneum] -- -- -- -- -- K01759 GLO1, gloA lactoylglutathione lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01759 Q6P7Q4 638 2.2e-65 Lactoylglutathione lyase OS=Rattus norvegicus GN=Glo1 PE=1 SV=3 -- -- GO:0005975//GO:0006090 carbohydrate metabolic process//pyruvate metabolic process GO:0004462//GO:0046872 lactoylglutathione lyase activity//metal ion binding -- -- KOG2944 Glyoxalase Cluster-8309.50806 BF_2 126.68 3.93 1634 332374764 AEE62523.1 1431 1.2e-155 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06126 COQ6 ubiquinone biosynthesis monooxygenase Coq6 http://www.genome.jp/dbget-bin/www_bget?ko:K06126 F1RAX8 980 1.0e-104 Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial OS=Danio rerio GN=coq6 PE=2 SV=1 PF08491//PF01266//PF07992//PF05834//PF01494 Squalene epoxidase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//FAD binding domain GO:0055114//GO:0006694//GO:0016117//GO:0016114 oxidation-reduction process//steroid biosynthetic process//carotenoid biosynthetic process//terpenoid biosynthetic process GO:0004506//GO:0050660//GO:0016491//GO:0016705//GO:0071949 squalene monooxygenase activity//flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding GO:0016021 integral component of membrane KOG3855 Monooxygenase involved in coenzyme Q (ubiquinone) biosynthesis Cluster-8309.50811 BF_2 32.66 0.98 1688 270001391 EEZ97838.1 1702 4.8e-187 hypothetical protein TcasGA2_TC000207 [Tribolium castaneum] -- -- -- -- -- K05860 PLCE phosphatidylinositol phospholipase C, epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K05860 Q9P212 192 2.5e-13 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 OS=Homo sapiens GN=PLCE1 PE=1 SV=3 PF01241//PF00788 Photosystem I psaG / psaK//Ras association (RalGDS/AF-6) domain GO:0015979//GO:0007165 photosynthesis//signal transduction -- -- GO:0016020//GO:0009522 membrane//photosystem I -- -- Cluster-8309.50812 BF_2 691.34 4.48 6737 642914941 XP_008190451.1 8103 0.0e+00 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like [Tribolium castaneum] 642914940 XM_008192229.1 1528 0 PREDICTED: Tribolium castaneum 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1-like (LOC661312), mRNA K05860 PLCE phosphatidylinositol phospholipase C, epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K05860 Q8K4S1 1352 3.0e-147 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 OS=Mus musculus GN=Plce1 PE=1 SV=3 PF00788//PF00168//PF00617//PF00387 Ras association (RalGDS/AF-6) domain//C2 domain//RasGEF domain//Phosphatidylinositol-specific phospholipase C, Y domain GO:0007264//GO:0035556//GO:0043087//GO:0006629//GO:0046339//GO:0007165//GO:0009395 small GTPase mediated signal transduction//intracellular signal transduction//regulation of GTPase activity//lipid metabolic process//diacylglycerol metabolic process//signal transduction//phospholipid catabolic process GO:0005515//GO:0005085//GO:0004435 protein binding//guanyl-nucleotide exchange factor activity//phosphatidylinositol phospholipase C activity -- -- -- -- Cluster-8309.50813 BF_2 2.33 0.34 574 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50814 BF_2 280.14 8.59 1652 646718490 KDR20930.1 993 7.7e-105 hypothetical protein L798_03868 [Zootermopsis nevadensis] -- -- -- -- -- K17889 ATG14L, ATG14 beclin 1-associated autophagy-related key regulator http://www.genome.jp/dbget-bin/www_bget?ko:K17889 D4A4K3 586 4.9e-59 Beclin 1-associated autophagy-related key regulator OS=Rattus norvegicus GN=Atg14 PE=3 SV=1 PF03951//PF10186//PF00643 Glutamine synthetase, beta-Grasp domain//Vacuolar sorting 38 and autophagy-related subunit 14//B-box zinc finger GO:0006542//GO:0010508//GO:0006807//GO:0009252 glutamine biosynthetic process//positive regulation of autophagy//nitrogen compound metabolic process//peptidoglycan biosynthetic process GO:0008270//GO:0004356 zinc ion binding//glutamate-ammonia ligase activity GO:0005622 intracellular -- -- Cluster-8309.50815 BF_2 594.00 57.01 723 478257892 ENN78032.1 370 5.9e-33 hypothetical protein YQE_05469, partial [Dendroctonus ponderosae]>gi|546676206|gb|ERL87273.1| hypothetical protein D910_04669 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03529 Otx1 transcription factor GO:0007275 multicellular organismal development GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.50817 BF_2 33.19 0.47 3217 167234455 NP_001107843.1 1160 6.5e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 3.0e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5082 BF_2 22.00 0.33 3071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13724 DNA-binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.50820 BF_2 1.00 3.14 268 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50821 BF_2 37.44 0.56 3060 642934333 XP_008198606.1 2626 6.3e-294 PREDICTED: tripartite motif-containing protein 2 isoform X4 [Tribolium castaneum] 817086197 XM_012410395.1 92 9.98018e-38 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 O75382 343 1.4e-30 Tripartite motif-containing protein 3 OS=Homo sapiens GN=TRIM3 PE=1 SV=2 PF01637//PF05149//PF13639//PF01580//PF02601//PF00097//PF05929//PF00643//PF14634//PF01436//PF05524//PF09815 Archaeal ATPase//Paraflagellar rod protein//Ring finger domain//FtsK/SpoIIIE family//Exonuclease VII, large subunit//Zinc finger, C3HC4 type (RING finger)//Phage capsid scaffolding protein (GPO) serine peptidase//B-box zinc finger//zinc-RING finger domain//NHL repeat//PEP-utilising enzyme, N-terminal//XK-related protein GO:0009401//GO:0019069//GO:0006308 phosphoenolpyruvate-dependent sugar phosphotransferase system//viral capsid assembly//DNA catabolic process GO:0003677//GO:0005524//GO:0005516//GO:0005515//GO:0008855//GO:0008270//GO:0000166//GO:0046872 DNA binding//ATP binding//calmodulin binding//protein binding//exodeoxyribonuclease VII activity//zinc ion binding//nucleotide binding//metal ion binding GO:0031514//GO:0016021//GO:0005622//GO:0009318 motile cilium//integral component of membrane//intracellular//exodeoxyribonuclease VII complex -- -- Cluster-8309.50824 BF_2 1.00 3.52 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50826 BF_2 4.62 0.44 725 642914292 XP_008201625.1 458 3.7e-43 PREDICTED: dual specificity mitogen-activated protein kinase kinase 7 [Tribolium castaneum] -- -- -- -- -- K04431 MAP2K7, MKK7 mitogen-activated protein kinase kinase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04431 -- -- -- -- PF08935 Viral protein VP4 subunit -- -- -- -- GO:0019030 icosahedral viral capsid -- -- Cluster-8309.50829 BF_2 38.00 3.97 688 861631908 KMQ90492.1 184 2.1e-11 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50840 BF_2 5.26 0.37 882 642911480 XP_008199442.1 685 2.1e-69 PREDICTED: retinol dehydrogenase 13-like [Tribolium castaneum]>gi|270014891|gb|EFA11339.1| hypothetical protein TcasGA2_TC010879 [Tribolium castaneum] -- -- -- -- -- K11161 RDH13 retinol dehydrogenase 13 http://www.genome.jp/dbget-bin/www_bget?ko:K11161 Q8NBN7 484 1.8e-47 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0016491//GO:0000166 oxidoreductase activity//nucleotide binding -- -- -- -- Cluster-8309.50841 BF_2 23.74 2.63 664 642911480 XP_008199442.1 770 2.2e-79 PREDICTED: retinol dehydrogenase 13-like [Tribolium castaneum]>gi|270014891|gb|EFA11339.1| hypothetical protein TcasGA2_TC010879 [Tribolium castaneum] -- -- -- -- -- K11152 RDH11 retinol dehydrogenase 11 http://www.genome.jp/dbget-bin/www_bget?ko:K11152 Q8TC12 508 2.2e-50 Retinol dehydrogenase 11 OS=Homo sapiens GN=RDH11 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0000166//GO:0016491 nucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.50844 BF_2 24.00 0.46 2492 642925978 XP_967909.2 1119 2.8e-119 PREDICTED: UNC93-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y115 304 3.7e-26 UNC93-like protein OS=Drosophila melanogaster GN=CG4928 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50846 BF_2 166.38 2.35 3247 642936096 XP_008198301.1 2202 9.7e-245 PREDICTED: PR domain zinc finger protein 10-like isoform X2 [Tribolium castaneum] 780701311 XM_011703805.1 79 1.7859e-30 PREDICTED: Wasmannia auropunctata PR domain zinc finger protein 10-like (LOC105458476), transcript variant X2, mRNA -- -- -- -- Q5RAX9 917 4.0e-97 PR domain zinc finger protein 10 OS=Pongo abelii GN=PRDM10 PE=2 SV=1 PF13912//PF09803//PF13465//PF00096 C2H2-type zinc finger//Uncharacterized conserved protein (DUF2346)//Zinc-finger double domain//Zinc finger, C2H2 type GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0046872 metal ion binding GO:0005739 mitochondrion -- -- Cluster-8309.50847 BF_2 1.00 1.37 302 820857060 XP_012345672.1 453 5.8e-43 PREDICTED: actin, clone 205-like isoform X1 [Apis florea] 295393578 GU992421.1 296 3.51352e-152 Scylla paramamosain beta-actin mRNA, complete cds K05692 ACTB_G1 actin beta/gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05692 P0DM42 449 6.9e-44 Actin-3 OS=Caenorhabditis elegans GN=act-3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.50849 BF_2 600.00 6.16 4362 642936291 XP_008198385.1 4280 0.0e+00 PREDICTED: nuclear pore complex protein Nup160 homolog [Tribolium castaneum] -- -- -- -- -- K14303 NUP160, NUP120 nuclear pore complex protein Nup160 http://www.genome.jp/dbget-bin/www_bget?ko:K14303 Q9VKJ3 1743 9.0e-193 Nuclear pore complex protein Nup160 homolog OS=Drosophila melanogaster GN=Nup160 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.50851 BF_2 33.00 2.35 874 270008756 EFA05204.1 320 4.4e-27 hypothetical protein TcasGA2_TC015340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P12276 166 1.3e-10 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 PF00975 Thioesterase domain GO:0009058 biosynthetic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.50852 BF_2 129.29 1.19 4850 642925057 XP_008194153.1 5276 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X4 [Tribolium castaneum] 874475179 XM_013100081.1 39 4.60893e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1850 3.9e-205 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.50853 BF_2 366.67 3.48 4689 189237993 XP_001812825.1 5381 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X2 [Tribolium castaneum] 874475179 XM_013100081.1 39 4.45479e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1864 9.0e-207 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.50854 BF_2 70.84 0.87 3710 642925057 XP_008194153.1 4997 0.0e+00 PREDICTED: tectonin beta-propeller repeat-containing protein isoform X4 [Tribolium castaneum] 874475179 XM_013100081.1 39 3.51749e-08 PREDICTED: Anas platyrhynchos tectonin beta-propeller repeat containing 1 (TECPR1), transcript variant X4, mRNA K17988 TECPR1 tectonin beta-propeller repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17988 Q9VWB0 1682 9.1e-186 Tectonin beta-propeller repeat-containing protein OS=Drosophila melanogaster GN=Pex23 PE=2 SV=2 PF00337 Galactoside-binding lectin -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.50856 BF_2 529.83 4.25 5505 642927195 XP_008195175.1 2564 1.7e-286 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50857 BF_2 51.18 0.41 5501 642927195 XP_008195175.1 2564 1.7e-286 PREDICTED: uncharacterized protein LOC662380 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50858 BF_2 71.00 1.14 2896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08063//PF09596 PADR1 (NUC008) domain//MamL-1 domain GO:0045944//GO:0007219 positive regulation of transcription from RNA polymerase II promoter//Notch signaling pathway GO:0003713//GO:0003950 transcription coactivator activity//NAD+ ADP-ribosyltransferase activity GO:0005667//GO:0016607//GO:0005634 transcription factor complex//nuclear speck//nucleus -- -- Cluster-8309.50859 BF_2 7.00 1.51 481 514692343 XP_004993744.1 207 3.1e-14 hypothetical protein PTSG_12268 [Salpingoeca rosetta]>gi|326427892|gb|EGD73462.1| hypothetical protein PTSG_12268 [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5086 BF_2 6.92 0.42 973 270015294 EFA11742.1 448 7.1e-42 hypothetical protein TcasGA2_TC005292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50860 BF_2 12.19 0.35 1726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50861 BF_2 426.96 7.18 2776 546684003 ERL93732.1 2078 2.0e-230 hypothetical protein D910_11018 [Dendroctonus ponderosae] 642929691 XM_970420.3 420 0 PREDICTED: Tribolium castaneum splicing factor 3B subunit 2 (LOC664413), transcript variant X2, mRNA K12829 SF3B2, SAP145, CUS1 splicing factor 3B subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12829 Q13435 1529 3.7e-168 Splicing factor 3B subunit 2 OS=Homo sapiens GN=SF3B2 PE=1 SV=2 PF04998//PF04037 RNA polymerase Rpb1, domain 5//Domain of unknown function (DUF382) GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005730 nucleus//nucleolus KOG2330 Splicing factor 3b, subunit 2 Cluster-8309.50864 BF_2 36.86 0.86 2073 546683453 ERL93259.1 310 1.5e-25 hypothetical protein D910_10555 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O01761 133 2.1e-06 Muscle M-line assembly protein unc-89 OS=Caenorhabditis elegans GN=unc-89 PE=1 SV=3 PF09788//PF11883 Transmembrane protein 55A//Domain of unknown function (DUF3403) GO:0016310//GO:0009069//GO:0046856 phosphorylation//serine family amino acid metabolic process//phosphatidylinositol dephosphorylation GO:0004674//GO:0034597 protein serine/threonine kinase activity//phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity -- -- -- -- Cluster-8309.50865 BF_2 389.90 7.31 2518 642930142 XP_008196269.1 1873 1.1e-206 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X3 [Tribolium castaneum] 189164165 EU545256.1 262 2.57745e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1247 1.7e-135 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.50866 BF_2 64.17 2.97 1192 189164166 ACD77184.1 1175 4.4e-126 putative hepatocyte nuclear factor 4 nuclear hormone receptor [Callosobruchus maculatus] 189164165 EU545256.1 262 1.20101e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 753 1.5e-78 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.50867 BF_2 138.59 2.14 2999 662209763 XP_008478495.1 561 1.7e-54 PREDICTED: uncharacterized protein LOC103515333 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.50868 BF_2 66.92 0.42 6954 386763496 NP_001245440.1 5465 0.0e+00 calcium activated protein for secretion, isoform E [Drosophila melanogaster]>gi|383293108|gb|AFH06800.1| calcium activated protein for secretion, isoform E [Drosophila melanogaster] 642910886 XM_008195228.1 1198 0 PREDICTED: Tribolium castaneum calcium-dependent secretion activator (LOC660877), transcript variant X6, mRNA -- -- -- -- Q9NHE5 3654 0.0e+00 Calcium-dependent secretion activator OS=Drosophila melanogaster GN=Caps PE=1 SV=3 PF11615 Protein of unknown function (DUF3249) GO:0072499//GO:0007476//GO:0016079//GO:0035249//GO:0000266//GO:0016477//GO:0008045//GO:0035147//GO:0046331//GO:0007156 photoreceptor cell axon guidance//imaginal disc-derived wing morphogenesis//synaptic vesicle exocytosis//synaptic transmission, glutamatergic//mitochondrial fission//cell migration//motor neuron axon guidance//branch fusion, open tracheal system//lateral inhibition//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005543 phospholipid binding GO:0005739//GO:0016020//GO:0042995//GO:0008021 mitochondrion//membrane//cell projection//synaptic vesicle KOG3543 Ca2+-dependent activator protein Cluster-8309.50871 BF_2 130.00 3.78 1724 642914683 XP_001815109.2 276 1.1e-21 PREDICTED: uncharacterized protein LOC100142559 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01093 Clusterin GO:0008219 cell death -- -- -- -- -- -- Cluster-8309.50872 BF_2 158.04 2.32 3142 642920703 XP_008192529.1 303 1.5e-24 PREDICTED: beta-taxilin-like isoform X2 [Tribolium castaneum]>gi|270006091|gb|EFA02539.1| hypothetical protein TcasGA2_TC008244 [Tribolium castaneum] -- -- -- -- -- K15712 TTC3 E3 ubiquitin-protein ligase TTC3 http://www.genome.jp/dbget-bin/www_bget?ko:K15712 Q86Y13 157 5.2e-09 E3 ubiquitin-protein ligase DZIP3 OS=Homo sapiens GN=DZIP3 PE=1 SV=2 PF13639//PF04420//PF12861//PF03938//PF11789//PF00097//PF14634//PF17123//PF12906//PF12678 Ring finger domain//CHD5-like protein//Anaphase-promoting complex subunit 11 RING-H2 finger//Outer membrane protein (OmpH-like)//Zinc-finger of the MIZ type in Nse subunit//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger//RING-variant domain//RING-H2 zinc finger GO:0016567//GO:0071816 protein ubiquitination//tail-anchored membrane protein insertion into ER membrane GO:0004842//GO:0005515//GO:0046872//GO:0051082//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//unfolded protein binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0800 FOG: Predicted E3 ubiquitin ligase Cluster-8309.50876 BF_2 264.09 6.56 1971 531445092 AGT57838.1 975 1.1e-102 cytochrome P450 413a1 [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- Q9V4U7 362 5.6e-33 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067//PF01833 Cytochrome P450//IPT/TIG domain GO:0055114 oxidation-reduction process GO:0020037//GO:0005515//GO:0005506//GO:0016705 heme binding//protein binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.50878 BF_2 32.17 0.35 4119 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50880 BF_2 162.83 1.79 4089 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50885 BF_2 164.75 2.02 3693 847046522 XP_012807721.1 797 9.2e-82 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 260-like [Jaculus jaculus] -- -- -- -- -- -- -- -- -- Q14590 769 6.7e-80 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF00096//PF02022//PF13465//PF13912//PF02723//PF07776 Zinc finger, C2H2 type//Integrase Zinc binding domain//Zinc-finger double domain//C2H2-type zinc finger//Non-structural protein NS3/Small envelope protein E//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.50887 BF_2 112.20 0.90 5489 91089161 XP_973772.1 3055 0.0e+00 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] 642932771 XM_968679.2 453 0 PREDICTED: Tribolium castaneum probable G-protein coupled receptor CG31760 (LOC662590), mRNA -- -- -- -- Q9VKA4 2243 1.2e-250 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50888 BF_2 68.30 0.53 5665 91089161 XP_973772.1 3055 0.0e+00 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] 642932771 XM_968679.2 444 0 PREDICTED: Tribolium castaneum probable G-protein coupled receptor CG31760 (LOC662590), mRNA -- -- -- -- Q9VKA4 2243 1.2e-250 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50889 BF_2 86.31 0.66 5765 91089161 XP_973772.1 3058 0.0e+00 PREDICTED: probable G-protein coupled receptor CG31760 [Tribolium castaneum] 642932771 XM_968679.2 459 0 PREDICTED: Tribolium castaneum probable G-protein coupled receptor CG31760 (LOC662590), mRNA -- -- -- -- Q9VKA4 2243 1.3e-250 Probable G-protein coupled receptor CG31760 OS=Drosophila melanogaster GN=CG31760 PE=1 SV=2 PF00003 7 transmembrane sweet-taste receptor of 3 GCPR GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.50890 BF_2 29.10 0.82 1763 642920867 XP_008192592.1 2528 8.3e-283 PREDICTED: protein turtle isoform X7 [Tribolium castaneum] 780702434 XM_011704077.1 434 0 PREDICTED: Wasmannia auropunctata protein turtle (LOC105458610), mRNA -- -- -- -- Q967D7 2226 3.6e-249 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF16656//PF07354//PF00041//PF13895//PF01108 Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Immunoglobulin domain//Tissue factor GO:0007339//GO:0019497//GO:0006771 binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0005515//GO:0046872//GO:0003993 protein binding//metal ion binding//acid phosphatase activity GO:0005576 extracellular region -- -- Cluster-8309.50892 BF_2 31.00 0.43 3283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05861 Bacterial phosphonate metabolism protein (PhnI) GO:0019634 organic phosphonate metabolic process -- -- -- -- -- -- Cluster-8309.50895 BF_2 2.00 18.72 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50896 BF_2 1.99 3.39 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50897 BF_2 47.83 0.96 2369 560922390 XP_006187394.1 378 2.3e-33 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 782-like [Camelus ferus] -- -- -- -- -- -- -- -- -- Q1LYE3 221 1.5e-16 Zinc finger protein 143 OS=Danio rerio GN=znf143 PE=2 SV=2 PF00096//PF13465//PF16622//PF02892//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//BED zinc finger//C2H2-type zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.50899 BF_2 172.00 5.91 1504 642927984 XP_008195472.1 747 2.3e-76 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50905 BF_2 286.42 12.30 1261 642914504 XP_008201703.1 1370 1.1e-148 PREDICTED: RUN and FYVE domain-containing protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WXA3 700 2.3e-72 RUN and FYVE domain-containing protein 2 OS=Homo sapiens GN=RUFY2 PE=1 SV=2 PF06005 Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737 cytoplasm -- -- Cluster-8309.50906 BF_2 1442.68 41.68 1735 728416727 AIY68319.1 1451 6.3e-158 putative beta-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 893 1.3e-94 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.50909 BF_2 102.36 2.42 2054 270014998 EFA11446.1 1919 4.0e-212 hypothetical protein TcasGA2_TC013628 [Tribolium castaneum] 746860780 XM_011062944.1 41 1.49476e-09 PREDICTED: Acromyrmex echinatior xanthine dehydrogenase-like (LOC105150088), transcript variant X2, mRNA -- -- -- -- P47990 835 8.2e-88 Xanthine dehydrogenase/oxidase OS=Gallus gallus GN=XDH PE=1 SV=1 PF02738//PF01313 Molybdopterin-binding domain of aldehyde dehydrogenase//Bacterial export proteins, family 3 GO:0055114//GO:0009306 oxidation-reduction process//protein secretion GO:0016491 oxidoreductase activity GO:0016020 membrane KOG0430 Xanthine dehydrogenase Cluster-8309.5091 BF_2 2.00 0.95 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50911 BF_2 33.36 0.87 1894 478259581 ENN79434.1 737 4.3e-75 hypothetical protein YQE_04078, partial [Dendroctonus ponderosae]>gi|546686694|gb|ERL95804.1| hypothetical protein D910_00332 [Dendroctonus ponderosae]>gi|546687578|gb|ERL96217.1| hypothetical protein D910_01476 [Dendroctonus ponderosae] -- -- -- -- -- K12193 VPS24, CHMP3 charged multivesicular body protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12193 Q4R574 569 5.3e-57 Charged multivesicular body protein 3 OS=Macaca fascicularis GN=CHMP3 PE=2 SV=3 PF03357 Snf7 GO:0007034 vacuolar transport -- -- -- -- KOG3229 Vacuolar sorting protein VPS24 Cluster-8309.50915 BF_2 55.42 1.48 1849 642913503 XP_008201041.1 1400 5.5e-152 PREDICTED: sorting nexin-4-like [Tribolium castaneum]>gi|270001727|gb|EEZ98174.1| hypothetical protein TcasGA2_TC000603 [Tribolium castaneum] -- -- -- -- -- K17919 SNX4 sorting nexin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K17919 A1A4L0 777 3.9e-81 Sorting nexin-4 OS=Bos taurus GN=SNX4 PE=2 SV=1 PF00787 PX domain GO:0007154 cell communication GO:0035091 phosphatidylinositol binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.5092 BF_2 8.00 0.54 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50920 BF_2 12.08 0.38 1632 189238634 XP_001811204.1 1894 2.5e-209 PREDICTED: tubulin gamma-1 chain isoform X2 [Tribolium castaneum] 532072251 XM_005321887.1 177 2.95637e-85 PREDICTED: Spermophilus tridecemlineatus tubulin, gamma 2 (Tubg2), mRNA K10389 TUBG tubulin gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10389 Q32KM1 1697 7.3e-188 Tubulin gamma-2 chain OS=Bos taurus GN=TUBG2 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1374 Gamma tubulin Cluster-8309.50922 BF_2 108.75 4.29 1348 642933817 XP_008197388.1 674 6.1e-68 PREDICTED: MICAL-like protein 1 [Tribolium castaneum]>gi|642933819|ref|XP_008197394.1| PREDICTED: MICAL-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TN34 370 4.5e-34 MICAL-like protein 2 OS=Mus musculus GN=Micall2 PE=1 SV=1 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50924 BF_2 26.47 0.45 2744 91090272 XP_970617.1 1298 5.5e-140 PREDICTED: nitrogen permease regulator 3-like protein [Tribolium castaneum]>gi|270013442|gb|EFA09890.1| hypothetical protein TcasGA2_TC012039 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUB4 676 3.0e-69 Nitrogen permease regulator 3-like protein OS=Drosophila melanogaster GN=CG8783 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3830 Uncharacterized conserved protein Cluster-8309.50925 BF_2 26.25 0.60 2129 675372920 KFM65822.1 141 6.2e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50927 BF_2 24.19 0.32 3480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50928 BF_2 1.00 0.37 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50933 BF_2 124.50 0.82 6603 546678769 ERL89321.1 3207 0.0e+00 hypothetical protein D910_06693 [Dendroctonus ponderosae] 815816223 XM_012373772.1 303 1.10019e-154 PREDICTED: Linepithema humile protein stoned-B (LOC105676122), transcript variant X2, mRNA -- -- -- -- Q24212 2445 5.4e-274 Protein stoned-B OS=Drosophila melanogaster GN=stnB PE=1 SV=4 -- -- -- -- -- -- -- -- KOG2677 Stoned B synaptic vesicle biogenesis protein Cluster-8309.50935 BF_2 768.33 12.43 2873 642920771 XP_008192553.1 1321 1.2e-142 PREDICTED: spondin-1-like [Tribolium castaneum]>gi|270005186|gb|EFA01634.1| hypothetical protein TcasGA2_TC007204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W770 831 3.4e-87 Spondin-1 OS=Gallus gallus GN=SPON1 PE=2 SV=1 PF08943//PF08925 CsiD//Domain of Unknown Function (DUF1907) -- -- GO:0005506 iron ion binding GO:0005634 nucleus KOG3539 Spondins, extracellular matrix proteins Cluster-8309.50938 BF_2 24.50 0.48 2424 478250251 ENN70751.1 405 1.7e-36 hypothetical protein YQE_12540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609//PF09057 Plant transposon protein//Transposase DDE domain//Second Mitochondria-derived Activator of Caspases GO:0006919//GO:0006313//GO:0006915 activation of cysteine-type endopeptidase activity involved in apoptotic process//transposition, DNA-mediated//apoptotic process GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity GO:0005739 mitochondrion -- -- Cluster-8309.50939 BF_2 20.10 0.40 2411 478250251 ENN70751.1 814 6.4e-84 hypothetical protein YQE_12540, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6AZB8 220 2.0e-16 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF09057//PF04827 Second Mitochondria-derived Activator of Caspases//Plant transposon protein GO:0006919//GO:0006915 activation of cysteine-type endopeptidase activity involved in apoptotic process//apoptotic process GO:0016788 hydrolase activity, acting on ester bonds GO:0005739 mitochondrion -- -- Cluster-8309.50941 BF_2 502.29 7.48 3095 189239405 XP_001813943.1 3364 0.0e+00 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] 637379439 XM_008125298.1 41 2.26402e-09 PREDICTED: Anolis carolinensis nuclear export mediator factor NEMF-like (LOC103282578), mRNA -- -- -- -- Q9VBX1 2205 1.7e-246 Nuclear export mediator factor NEMF homolog OS=Drosophila melanogaster GN=Clbn PE=1 SV=2 PF08052 PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process -- -- -- -- KOG2030 Predicted RNA-binding protein Cluster-8309.50943 BF_2 15.52 0.36 2104 189239405 XP_001813943.1 2436 4.6e-272 PREDICTED: nuclear export mediator factor NEMF homolog [Tribolium castaneum]>gi|270010510|gb|EFA06958.1| hypothetical protein TcasGA2_TC009916 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O60524 1740 9.7e-193 Nuclear export mediator factor NEMF OS=Homo sapiens GN=NEMF PE=1 SV=4 PF05615//PF02050//PF08052 Tho complex subunit 7//Flagellar FliJ protein//PyrBI operon leader peptide GO:0019856//GO:0071973//GO:0006397//GO:0006935 pyrimidine nucleobase biosynthetic process//bacterial-type flagellum-dependent cell motility//mRNA processing//chemotaxis GO:0003774 motor activity GO:0000445//GO:0016020//GO:0009288 THO complex part of transcription export complex//membrane//bacterial-type flagellum KOG2030 Predicted RNA-binding protein Cluster-8309.50945 BF_2 33.66 0.67 2403 642921818 XP_008199331.1 1173 1.5e-125 PREDICTED: vitamin K-dependent gamma-carboxylase [Tribolium castaneum] -- -- -- -- -- K10106 GGCX vitamin K-dependent gamma-carboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10106 Q9MYY3 693 2.8e-71 Vitamin K-dependent gamma-carboxylase OS=Delphinapterus leucas GN=GGCX PE=2 SV=1 PF05090 Vitamin K-dependent gamma-carboxylase GO:0017187 peptidyl-glutamic acid carboxylation GO:0008488 gamma-glutamyl carboxylase activity -- -- -- -- Cluster-8309.50946 BF_2 34.19 0.36 4250 91077592 XP_973319.1 1821 1.9e-200 PREDICTED: decaprenyl-diphosphate synthase subunit 1 [Tribolium castaneum] 645030079 XM_008211983.1 197 5.94392e-96 PREDICTED: Nasonia vitripennis decaprenyl-diphosphate synthase subunit 1 (LOC100118369), transcript variant X4, mRNA K12504 PDSS1 decaprenyl-diphosphate synthase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12504 Q5T2R2 916 6.9e-97 Decaprenyl-diphosphate synthase subunit 1 OS=Homo sapiens GN=PDSS1 PE=1 SV=1 PF01783//PF00348 Ribosomal L32p protein family//Polyprenyl synthetase GO:0008299//GO:0006412//GO:0042254 isoprenoid biosynthetic process//translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG0776 Geranylgeranyl pyrophosphate synthase/Polyprenyl synthetase Cluster-8309.50948 BF_2 2.00 0.33 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50949 BF_2 186.39 8.17 1241 642916768 XP_008192537.1 517 9.0e-50 PREDICTED: peptidoglycan-recognition protein LA-like [Tribolium castaneum]>gi|270004831|gb|EFA01279.1| hypothetical protein TcasGA2_TC002789 [Tribolium castaneum] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q8SXQ7 284 3.9e-24 Peptidoglycan-recognition protein LF OS=Drosophila melanogaster GN=PGRP-LF PE=1 SV=1 PF06422//PF01510 CDR ABC transporter//N-acetylmuramoyl-L-alanine amidase GO:0006810//GO:0009253//GO:0009252//GO:0006807 transport//peptidoglycan catabolic process//peptidoglycan biosynthetic process//nitrogen compound metabolic process GO:0005524//GO:0042626//GO:0008745 ATP binding//ATPase activity, coupled to transmembrane movement of substances//N-acetylmuramoyl-L-alanine amidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.50950 BF_2 136.00 1.69 3645 91087405 XP_975667.1 2806 0.0e+00 PREDICTED: structural maintenance of chromosomes protein 5 [Tribolium castaneum]>gi|270009507|gb|EFA05955.1| hypothetical protein TcasGA2_TC008773 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CG46 1362 1.1e-148 Structural maintenance of chromosomes protein 5 OS=Mus musculus GN=Smc5 PE=2 SV=1 PF13851//PF02183//PF13304 Growth-arrest specific micro-tubule binding//Homeobox associated leucine zipper//AAA domain, putative AbiEii toxin, Type IV TA system GO:0048870//GO:0006355 cell motility//regulation of transcription, DNA-templated GO:0003700//GO:0005524//GO:0043565 transcription factor activity, sequence-specific DNA binding//ATP binding//sequence-specific DNA binding GO:0005667//GO:0031514 transcription factor complex//motile cilium KOG0979 Structural maintenance of chromosome protein SMC5/Spr18, SMC superfamily Cluster-8309.50951 BF_2 81.47 4.52 1042 642933095 XP_008197256.1 395 1.1e-35 PREDICTED: protein Gawky isoform X1 [Tribolium castaneum]>gi|642933097|ref|XP_008197257.1| PREDICTED: protein Gawky isoform X1 [Tribolium castaneum] 642933104 XM_008199038.1 408 0 PREDICTED: Tribolium castaneum protein Gawky (LOC661812), transcript variant X6, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50952 BF_2 104.16 0.47 9485 642918629 XP_008200387.1 1253 3.1e-134 PREDICTED: serine/threonine-protein phosphatase 6 regulatory subunit 3 isoform X2 [Tribolium castaneum] 642918632 XM_008202178.1 261 3.52515e-131 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase 6 regulatory subunit 3 (LOC655675), transcript variant X5, mRNA K15501 PPP6R3, SAPS3 serine/threonine-protein phosphatase 6 regulatory subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15501 O75170 775 3.4e-80 Serine/threonine-protein phosphatase 6 regulatory subunit 2 OS=Homo sapiens GN=PPP6R2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2073 SAP family cell cycle dependent phosphatase-associated protein Cluster-8309.5096 BF_2 27.00 0.44 2852 642917435 XP_008191197.1 979 5.6e-103 PREDICTED: uncharacterized protein LOC103312417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50961 BF_2 186.66 7.31 1356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50963 BF_2 221.52 4.74 2241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50966 BF_2 76.00 2.54 1537 478254156 ENN74435.1 873 5.9e-91 hypothetical protein YQE_08970, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O54905 329 2.9e-29 Beta-1,3-galactosyltransferase 2 OS=Mus musculus GN=B3galt2 PE=2 SV=2 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.50967 BF_2 464.09 3.35 6074 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50968 BF_2 158.23 3.11 2415 532107609 XP_005338536.1 469 6.5e-44 PREDICTED: zinc finger protein 420-like [Ictidomys tridecemlineatus] -- -- -- -- -- -- -- -- -- Q9UJU3 432 5.2e-41 Zinc finger protein 112 OS=Homo sapiens GN=ZNF112 PE=2 SV=2 PF13912//PF16622//PF05191//PF00096//PF10392//PF13465 C2H2-type zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc finger, C2H2 type//Golgi transport complex subunit 5//Zinc-finger double domain GO:0006891//GO:0046034//GO:0006144 intra-Golgi vesicle-mediated transport//ATP metabolic process//purine nucleobase metabolic process GO:0046872//GO:0004017 metal ion binding//adenylate kinase activity GO:0017119 Golgi transport complex -- -- Cluster-8309.50970 BF_2 4.00 0.89 475 328703894 XP_001945611.2 153 5.6e-08 PREDICTED: uncharacterized protein LOC100164320 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50971 BF_2 179.09 1.35 5830 752891325 XP_011263696.1 1568 5.7e-171 PREDICTED: uncharacterized protein LOC105255869 [Camponotus floridanus] 752891324 XM_011265394.1 393 0 PREDICTED: Camponotus floridanus uncharacterized LOC105255869 (LOC105255869), mRNA -- -- -- -- -- -- -- -- PF07927 HicA toxin of bacterial toxin-antitoxin, -- -- GO:0003729 mRNA binding -- -- -- -- Cluster-8309.50972 BF_2 87.53 1.36 2973 91085955 XP_971224.1 3102 0.0e+00 PREDICTED: integrator complex subunit 8 [Tribolium castaneum]>gi|270010172|gb|EFA06620.1| hypothetical protein TcasGA2_TC009538 [Tribolium castaneum] -- -- -- -- -- K13145 INTS8 integrator complex subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13145 Q80V86 755 2.3e-78 Integrator complex subunit 8 OS=Mus musculus GN=Ints8 PE=2 SV=1 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.50977 BF_2 338.24 5.04 3097 91089209 XP_967093.1 2991 0.0e+00 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog [Tribolium castaneum]>gi|270012470|gb|EFA08918.1| hypothetical protein TcasGA2_TC006624 [Tribolium castaneum] -- -- -- -- -- K14439 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14439 Q9VL72 1791 1.7e-198 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 homolog OS=Drosophila melanogaster GN=Etl1 PE=1 SV=1 PF00270//PF00176//PF02845//PF04851 DEAD/DEAH box helicase//SNF2 family N-terminal domain//CUE domain//Type III restriction enzyme, res subunit -- -- GO:0005515//GO:0003676//GO:0003677//GO:0016787//GO:0005524 protein binding//nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0389 SNF2 family DNA-dependent ATPase Cluster-8309.50980 BF_2 27.59 0.61 2175 742090774 XP_010831732.1 722 2.7e-73 PREDICTED: zinc finger protein 665-like, partial [Bison bison bison] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZN08 696 1.1e-71 Putative zinc finger protein 66 OS=Homo sapiens GN=ZNF66 PE=5 SV=3 PF07776//PF16622//PF13912//PF05864//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677//GO:0008270//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//zinc ion binding//metal ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.50982 BF_2 51.60 1.38 1856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50983 BF_2 798.80 13.22 2815 642912548 XP_008200908.1 1126 5.0e-120 PREDICTED: collagen and calcium-binding EGF domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXH8 366 2.7e-33 Collagen and calcium-binding EGF domain-containing protein 1 OS=Homo sapiens GN=CCBE1 PE=1 SV=1 PF00008//PF07645 EGF-like domain//Calcium-binding EGF domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.50986 BF_2 89.00 1.69 2490 642935733 XP_008198149.1 915 1.3e-95 PREDICTED: proteoglycan 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50987 BF_2 425.00 11.53 1829 270008070 EFA04518.1 612 1.3e-60 hypothetical protein TcasGA2_TC016313 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.50989 BF_2 178.11 0.97 7999 642920861 XP_008192589.1 3650 0.0e+00 PREDICTED: protein turtle isoform X4 [Tribolium castaneum] 642920860 XM_008194367.1 630 0 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X9, mRNA -- -- -- -- Q967D7 3150 0.0e+00 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 PF01108//PF07353//PF02480//PF16656//PF07354//PF13895//PF00041 Tissue factor//Uroplakin II//Alphaherpesvirus glycoprotein E//Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0061024//GO:0019497//GO:0007339 riboflavin metabolic process//membrane organization//hexachlorocyclohexane metabolic process//binding of sperm to zona pellucida GO:0046872//GO:0003993//GO:0005515 metal ion binding//acid phosphatase activity//protein binding GO:0016020//GO:0005576//GO:0030176 membrane//extracellular region//integral component of endoplasmic reticulum membrane -- -- Cluster-8309.50990 BF_2 144.55 1.71 3820 189234149 XP_971128.2 773 5.8e-79 PREDICTED: uncharacterized protein LOC659761 [Tribolium castaneum]>gi|270002466|gb|EEZ98913.1| hypothetical protein TcasGA2_TC004532 [Tribolium castaneum] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q9VW97 195 2.5e-13 Possible lysine-specific histone demethylase 1 OS=Drosophila melanogaster GN=Su(var)3-3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.50991 BF_2 223.32 15.71 882 91076902 XP_975035.1 815 1.8e-84 PREDICTED: pseudouridine-5'-monophosphatase [Tribolium castaneum]>gi|270001800|gb|EEZ98247.1| hypothetical protein TcasGA2_TC000686 [Tribolium castaneum] -- -- -- -- -- K17623 HDHD1 pseudouridine-5'-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K17623 Q94529 500 2.5e-49 Probable pseudouridine-5'-phosphatase OS=Drosophila melanogaster GN=Gs1l PE=2 SV=2 PF05656//PF15894 Protein of unknown function (DUF805)//Inhibitor of glucose uptake transporter SgrT GO:0046325 negative regulation of glucose import GO:0016787 hydrolase activity GO:0016021 integral component of membrane KOG2914 Predicted haloacid-halidohydrolase and related hydrolases Cluster-8309.50994 BF_2 594.98 66.40 662 332375022 AEE62652.1 556 1.4e-54 unknown [Dendroctonus ponderosae] -- -- -- -- -- K03955 NDUFAB1 NADH dehydrogenase (ubiquinone) 1 alpha/beta subcomplex 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03955 Q94519 396 2.1e-37 Acyl carrier protein, mitochondrial OS=Drosophila melanogaster GN=mtacp1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1748 Acyl carrier protein/NADH-ubiquinone oxidoreductase, NDUFAB1/SDAP subunit Cluster-8309.50995 BF_2 123.88 0.94 5797 642935609 XP_008198080.1 4494 0.0e+00 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7C5 1453 5.1e-159 Phosphatidylinositide phosphatase SAC2 OS=Danio rerio GN=inpp5f PE=3 SV=1 PF02383//PF03092//PF06056 SacI homology domain//BT1 family//Putative ATPase subunit of terminase (gpP-like) GO:0006810//GO:0019069 transport//viral capsid assembly GO:0005524//GO:0042578 ATP binding//phosphoric ester hydrolase activity GO:0016021 integral component of membrane KOG1889 Putative phosphoinositide phosphatase Cluster-8309.50998 BF_2 145.08 1.34 4830 270013073 EFA09521.1 1113 2.7e-118 hypothetical protein TcasGA2_TC011623 [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 Q5SWT3 770 6.7e-80 Solute carrier family 25 member 35 OS=Mus musculus GN=Slc25a35 PE=2 SV=2 PF07714//PF00069//PF01674 Protein tyrosine kinase//Protein kinase domain//Lipase (class 2) GO:0006468 protein phosphorylation GO:0016787//GO:0005524//GO:0004672 hydrolase activity//ATP binding//protein kinase activity -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.5100 BF_2 4.00 0.33 789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51000 BF_2 54.00 12.34 470 642924825 XP_967668.2 489 6.0e-47 PREDICTED: uncharacterized protein LOC656019 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 284 1.5e-24 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51003 BF_2 20.14 0.49 1999 189239183 XP_966847.2 1313 7.3e-142 PREDICTED: non-lysosomal glucosylceramidase [Tribolium castaneum]>gi|270010940|gb|EFA07388.1| hypothetical protein TcasGA2_TC016367 [Tribolium castaneum] -- -- -- -- -- K17108 GBA2 non-lysosomal glucosylceramidase http://www.genome.jp/dbget-bin/www_bget?ko:K17108 Q7KT91 852 8.6e-90 Non-lysosomal glucosylceramidase OS=Drosophila melanogaster GN=CG33090 PE=1 SV=1 PF04685 Protein of unknown function, DUF608 GO:0006680//GO:0006807//GO:0006687//GO:0005975//GO:0006665 glucosylceramide catabolic process//nitrogen compound metabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//sphingolipid metabolic process GO:0004348 glucosylceramidase activity GO:0016021//GO:0005886 integral component of membrane//plasma membrane KOG2119 Predicted bile acid beta-glucosidase Cluster-8309.51004 BF_2 2.00 0.52 449 264667365 ACY71268.1 314 1.1e-26 ribosomal protein S23 [Chrysomela tremula] 769857176 XM_011641913.1 101 1.36454e-43 PREDICTED: Pogonomyrmex barbatus 40S ribosomal protein S23 (LOC105429139), mRNA K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q6EV23 313 6.1e-28 40S ribosomal protein S23 OS=Papilio dardanus GN=RpS23 PE=2 SV=1 PF00164 Ribosomal protein S12/S23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1749 40S ribosomal protein S23 Cluster-8309.51005 BF_2 103.02 0.39 11281 91088037 XP_974425.1 3153 0.0e+00 PREDICTED: ring canal kelch homolog [Tribolium castaneum] -- -- -- -- -- K10443 KLHL2_3 kelch-like protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K10443 Q70JS2 2332 1.2e-260 Ring canal kelch homolog OS=Anopheles stephensi GN=kel PE=2 SV=2 PF07646//PF00651//PF01344//PF00856 Kelch motif//BTB/POZ domain//Kelch motif//SET domain -- -- GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.51006 BF_2 7.00 0.79 657 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51007 BF_2 117.50 0.55 9230 478249960 ENN70467.1 2128 1.1e-235 hypothetical protein YQE_12970, partial [Dendroctonus ponderosae] -- -- -- -- -- K10777 LIG4, DNL4 DNA ligase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10777 Q90YB1 1021 1.0e-108 DNA ligase 4 OS=Gallus gallus GN=LIG4 PE=2 SV=2 PF01068//PF11411//PF06814//PF04679//PF04675 ATP dependent DNA ligase domain//DNA ligase IV//Lung seven transmembrane receptor//ATP dependent DNA ligase C terminal region//DNA ligase N terminus GO:0006260//GO:0006310//GO:0006281 DNA replication//DNA recombination//DNA repair GO:0003677//GO:0005524//GO:0003910 DNA binding//ATP binding//DNA ligase (ATP) activity GO:0016021 integral component of membrane KOG0966 ATP-dependent DNA ligase IV Cluster-8309.51008 BF_2 3.00 0.71 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5101 BF_2 10.86 1.08 707 91092754 XP_973448.1 544 3.8e-53 PREDICTED: Werner Syndrome-like exonuclease [Tribolium castaneum]>gi|270014889|gb|EFA11337.1| hypothetical protein TcasGA2_TC010877 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4PLB3 389 1.5e-36 Werner Syndrome-like exonuclease OS=Drosophila yakuba GN=WRNexo PE=3 SV=1 PF01612 3'-5' exonuclease GO:0006139 nucleobase-containing compound metabolic process GO:0003676//GO:0008408 nucleic acid binding//3'-5' exonuclease activity -- -- -- -- Cluster-8309.51010 BF_2 153.42 1.30 5233 817052050 XP_012254225.1 1947 5.8e-215 PREDICTED: cGMP-dependent 3',5'-cyclic phosphodiesterase-like isoform X2 [Athalia rosae] -- -- -- -- -- K18283 PDE2A cGMP-dependent 3',5'-cyclic phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K18283 P14099 1564 6.2e-172 cGMP-dependent 3',5'-cyclic phosphodiesterase OS=Bos taurus GN=PDE2A PE=1 SV=2 PF00233//PF01590//PF13492//PF05699//PF11590//PF13185//PF00494 3'5'-cyclic nucleotide phosphodiesterase//GAF domain//GAF domain//hAT family C-terminal dimerisation region//DNA polymerase catalytic subunit Pol//GAF domain//Squalene/phytoene synthase GO:0051252//GO:0009058//GO:0006260//GO:0006144//GO:0007165 regulation of RNA metabolic process//biosynthetic process//DNA replication//purine nucleobase metabolic process//signal transduction GO:0004523//GO:0046983//GO:0003887//GO:0005515//GO:0004114//GO:0016740 RNA-DNA hybrid ribonuclease activity//protein dimerization activity//DNA-directed DNA polymerase activity//protein binding//3',5'-cyclic-nucleotide phosphodiesterase activity//transferase activity GO:0042575 DNA polymerase complex KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.51013 BF_2 33.00 0.80 2015 478252125 ENN72556.1 906 1.1e-94 hypothetical protein YQE_10896, partial [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 351 1.1e-31 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 PF03144//PF00107 Elongation factor Tu domain 2//Zinc-binding dehydrogenase GO:0055114 oxidation-reduction process GO:0005525 GTP binding -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.51014 BF_2 13.76 0.64 1193 642929442 XP_008195842.1 1014 2.0e-107 PREDICTED: transient receptor potential cation channel trpm isoform X3 [Tribolium castaneum] -- -- -- -- -- K04978 TRPM3 transient receptor potential cation channel subfamily M member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04978 A8DYE2 694 1.1e-71 Transient receptor potential cation channel trpm OS=Drosophila melanogaster GN=Trpm PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3614 Ca2+/Mg2+-permeable cation channels (LTRPC family) Cluster-8309.51015 BF_2 131.00 1.65 3608 646724190 KDR24525.1 1729 7.6e-190 WD repeat-containing protein 40A, partial [Zootermopsis nevadensis] -- -- -- -- -- K11803 WDR40A WD repeat-containing protein 40A http://www.genome.jp/dbget-bin/www_bget?ko:K11803 Q4R3J7 828 9.4e-87 DDB1- and CUL4-associated factor 12 OS=Macaca fascicularis GN=DCAF12 PE=2 SV=1 PF00400//PF03178 WD domain, G-beta repeat//CPSF A subunit region -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.51016 BF_2 284.84 5.52 2444 642938254 XP_008198131.1 1462 4.7e-159 PREDICTED: disintegrin and metalloproteinase domain-containing protein 10 isoform X2 [Tribolium castaneum] 642938253 XM_008199909.1 218 7.20304e-108 PREDICTED: Tribolium castaneum disintegrin and metalloproteinase domain-containing protein 10 (LOC659820), transcript variant X2, mRNA K06704 ADAM10 disintegrin and metalloproteinase domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06704 Q8JIY1 635 1.5e-64 Disintegrin and metalloproteinase domain-containing protein 10 OS=Xenopus laevis GN=adam10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3658 Tumor necrosis factor-alpha-converting enzyme (TACE/ADAM17) and related metalloproteases Cluster-8309.51017 BF_2 96.18 0.47 8853 642934043 XP_008197617.1 1005 1.7e-105 PREDICTED: kelch-like protein 38 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9J569 208 1.8e-14 Putative ankyrin repeat protein FPV162 OS=Fowlpox virus (strain NVSL) GN=FPV162 PE=3 SV=1 PF13606//PF01370//PF00023//PF00651//PF07646//PF01344 Ankyrin repeat//NAD dependent epimerase/dehydratase family//Ankyrin repeat//BTB/POZ domain//Kelch motif//Kelch motif -- -- GO:0005515//GO:0050662//GO:0003824 protein binding//coenzyme binding//catalytic activity -- -- KOG4177 Ankyrin Cluster-8309.5102 BF_2 23.60 0.47 2369 646693425 KDR07697.1 516 2.3e-49 Proton-coupled amino acid transporter 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00955//PF03222//PF03402//PF04272//PF13520 HCO3- transporter family//Tryptophan/tyrosine permease family//Vomeronasal organ pheromone receptor family, V1R//Phospholamban//Amino acid permease GO:0006810//GO:0006865//GO:0006816//GO:0019236//GO:0007606//GO:0006820//GO:0007186//GO:0003333 transport//amino acid transport//calcium ion transport//response to pheromone//sensory perception of chemical stimulus//anion transport//G-protein coupled receptor signaling pathway//amino acid transmembrane transport GO:0016503//GO:0042030//GO:0005246//GO:0015171 pheromone receptor activity//ATPase inhibitor activity//calcium channel regulator activity//amino acid transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.51020 BF_2 5.00 3.14 349 746843684 XP_011052079.1 152 5.3e-08 PREDICTED: uncharacterized protein LOC105144710, partial [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02543//PF00816 Carbamoyltransferase N-terminus//H-NS histone family GO:0006355//GO:0009058 regulation of transcription, DNA-templated//biosynthetic process GO:0003677//GO:0003824 DNA binding//catalytic activity GO:0005622 intracellular -- -- Cluster-8309.51023 BF_2 47.20 1.18 1963 270011441 EFA07889.1 1403 2.6e-152 hypothetical protein TcasGA2_TC005464 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 168 1.7e-10 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51025 BF_2 14.49 0.56 1372 642915588 XP_008190677.1 1743 6.9e-192 PREDICTED: tyrosine-protein phosphatase Lar isoform X3 [Tribolium castaneum] -- -- -- -- -- K06777 PTPRD receptor-type tyrosine-protein phosphatase delta http://www.genome.jp/dbget-bin/www_bget?ko:K06777 P16621 1339 2.0e-146 Tyrosine-protein phosphatase Lar OS=Drosophila melanogaster GN=Lar PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51027 BF_2 1.00 1.40 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51031 BF_2 91.41 1.42 2982 642939887 XP_008200200.1 2712 6.5e-304 PREDICTED: enhancer of mRNA-decapping protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12616 EDC4 enhancer of mRNA-decapping protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K12616 Q1LUT1 565 2.4e-56 Enhancer of mRNA-decapping protein 4 OS=Danio rerio GN=edc4 PE=3 SV=1 PF07464//PF08236//PF06152//PF01442//PF04216 Apolipophorin-III precursor (apoLp-III)//SRI (Set2 Rpb1 interacting) domain//Phage minor capsid protein 2//Apolipoprotein A1/A4/E domain//Protein involved in formate dehydrogenase formation GO:0006869//GO:0034968//GO:0042157//GO:0006554//GO:0006355//GO:0006479 lipid transport//histone lysine methylation//lipoprotein metabolic process//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005198//GO:0008289//GO:0018024 structural molecule activity//lipid binding//histone-lysine N-methyltransferase activity GO:0019028//GO:0005737//GO:0005576//GO:0005694 viral capsid//cytoplasm//extracellular region//chromosome KOG1916 Nuclear protein, contains WD40 repeats Cluster-8309.51037 BF_2 116.60 1.33 3952 478251563 ENN72025.1 1587 2.4e-173 hypothetical protein YQE_11316, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RGJ5 846 8.4e-89 CWF19-like protein 1 OS=Danio rerio GN=cwf19l1 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG2476 Uncharacterized conserved protein Cluster-8309.51038 BF_2 400.84 10.75 1847 646226754 CDF77374.1 676 4.9e-68 CD63 protein [Tenebrio molitor] 817053829 XM_012408690.1 49 4.79092e-14 PREDICTED: Athalia rosae CD63 antigen-like (LOC105690669), mRNA K06497 CD63, MLA1, TSPAN30 CD63 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06497 Q6GMK6 250 5.1e-20 Tetraspanin-9 OS=Danio rerio GN=tspan9 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG3882 Tetraspanin family integral membrane protein Cluster-8309.51039 BF_2 119.00 1.69 3240 642936007 XP_008198265.1 2144 5.2e-238 PREDICTED: uncharacterized protein LOC662355 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17725 ETHE1 sulfur dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K17725 -- -- -- -- PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51044 BF_2 85.19 2.04 2031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.51045 BF_2 275.00 1.96 6160 642929931 XP_008196030.1 3940 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 [Tribolium castaneum] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 C5FYZ3 716 1.6e-73 Probable dipeptidyl-aminopeptidase B OS=Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) GN=DAPB PE=3 SV=1 PF00930//PF05739//PF02129//PF07859//PF02230//PF03403//PF00326 Dipeptidyl peptidase IV (DPP IV) N-terminal region//SNARE domain//X-Pro dipeptidyl-peptidase (S15 family)//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Platelet-activating factor acetylhydrolase, isoform II//Prolyl oligopeptidase family GO:0046486//GO:0016042//GO:0006508//GO:0008152 glycerolipid metabolic process//lipid catabolic process//proteolysis//metabolic process GO:0008236//GO:0005515//GO:0003847//GO:0016787 serine-type peptidase activity//protein binding//1-alkyl-2-acetylglycerophosphocholine esterase activity//hydrolase activity GO:0008247 1-alkyl-2-acetylglycerophosphocholine esterase complex KOG2100 Dipeptidyl aminopeptidase Cluster-8309.51048 BF_2 105.87 3.32 1623 91080473 XP_970438.1 562 7.2e-55 PREDICTED: mitochondrial inner membrane protease subunit 1 [Tribolium castaneum]>gi|270005561|gb|EFA02009.1| hypothetical protein TcasGA2_TC007631 [Tribolium castaneum] -- -- -- -- -- K09647 IMP1 mitochondrial inner membrane protease subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09647 Q96LU5 398 3.1e-37 Mitochondrial inner membrane protease subunit 1 OS=Homo sapiens GN=IMMP1L PE=2 SV=1 -- -- GO:0006508 proteolysis GO:0008236 serine-type peptidase activity GO:0016021 integral component of membrane KOG0171 Mitochondrial inner membrane protease, subunit IMP1 Cluster-8309.51052 BF_2 59.29 0.54 4860 478255815 ENN76023.1 1513 1.1e-164 hypothetical protein YQE_07399, partial [Dendroctonus ponderosae] -- -- -- -- -- K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q9Z136 486 5.7e-47 Hamartin OS=Rattus norvegicus GN=Tsc1 PE=1 SV=1 PF06005 Protein of unknown function (DUF904) GO:0000917//GO:0043093 barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0005737 cytoplasm KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.51057 BF_2 56.93 1.55 1827 91089563 XP_971820.1 657 7.8e-66 PREDICTED: diphthamide biosynthesis protein 7 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9CYU6 373 2.7e-34 Diphthine methyltransferase OS=Mus musculus GN=Dph7 PE=2 SV=1 PF07127 Late nodulin protein GO:0009878 nodule morphogenesis GO:0046872 metal ion binding -- -- -- -- Cluster-8309.51059 BF_2 23.12 0.45 2452 270012598 EFA09046.1 325 3.3e-27 hypothetical protein TcasGA2_TC006759 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q55C80 211 2.2e-15 Diphthine methyltransferase homolog OS=Dictyostelium discoideum GN=wdr85 PE=3 SV=1 PF04137//PF05699 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)//hAT family C-terminal dimerisation region GO:0055114 oxidation-reduction process GO:0016671//GO:0003756//GO:0046983 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor//protein disulfide isomerase activity//protein dimerization activity GO:0005783 endoplasmic reticulum KOG0280 Uncharacterized conserved protein Cluster-8309.51060 BF_2 73.43 1.00 3354 768413304 XP_011568765.1 398 1.5e-35 PREDICTED: uncharacterized protein LOC105398382 [Plutella xylostella] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9BTV6 216 8.0e-16 Diphthine methyltransferase OS=Homo sapiens GN=DPH7 PE=1 SV=2 PF06874//PF01596//PF00322//PF07127 Firmicute fructose-1,6-bisphosphatase//O-methyltransferase//Endothelin family//Late nodulin protein GO:0006096//GO:0006098//GO:0019229//GO:0009878//GO:0006094//GO:0015976//GO:0006000//GO:0006013 glycolytic process//pentose-phosphate shunt//regulation of vasoconstriction//nodule morphogenesis//gluconeogenesis//carbon utilization//fructose metabolic process//mannose metabolic process GO:0008171//GO:0042132//GO:0046872 O-methyltransferase activity//fructose 1,6-bisphosphate 1-phosphatase activity//metal ion binding GO:0005576 extracellular region -- -- Cluster-8309.51061 BF_2 35.83 0.48 3407 91089563 XP_971820.1 517 2.5e-49 PREDICTED: diphthamide biosynthesis protein 7 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q9BTV6 309 1.3e-26 Diphthine methyltransferase OS=Homo sapiens GN=DPH7 PE=1 SV=2 PF06874//PF01596//PF00322 Firmicute fructose-1,6-bisphosphatase//O-methyltransferase//Endothelin family GO:0006096//GO:0006098//GO:0019229//GO:0006094//GO:0015976//GO:0006013//GO:0006000 glycolytic process//pentose-phosphate shunt//regulation of vasoconstriction//gluconeogenesis//carbon utilization//mannose metabolic process//fructose metabolic process GO:0008171//GO:0042132 O-methyltransferase activity//fructose 1,6-bisphosphate 1-phosphatase activity GO:0005576 extracellular region -- -- Cluster-8309.51062 BF_2 13.88 2.29 541 270012598 EFA09046.1 338 2.2e-29 hypothetical protein TcasGA2_TC006759 [Tribolium castaneum] -- -- -- -- -- K17868 DPH7, RRT2 diphthamide biosynthesis protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K17868 Q55C80 230 3.1e-18 Diphthine methyltransferase homolog OS=Dictyostelium discoideum GN=wdr85 PE=3 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0280 Uncharacterized conserved protein Cluster-8309.51070 BF_2 6.45 0.52 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51072 BF_2 39.51 0.32 5416 642936622 XP_008198510.1 3086 0.0e+00 PREDICTED: uncharacterized protein LOC661743 isoform X2 [Tribolium castaneum] 642936623 XM_008200289.1 120 4.83309e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.4e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF02346//PF01166 Chordopoxvirus multifunctional envelope protein A27//TSC-22/dip/bun family GO:0006355//GO:0019064 regulation of transcription, DNA-templated//fusion of virus membrane with host plasma membrane GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.51074 BF_2 34.00 1.28 1400 642912272 XP_008200632.1 381 6.0e-34 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q90WD8 219 1.5e-16 Ovochymase-2 OS=Bufo japonicus GN=OVCH2 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.51076 BF_2 60.95 1.37 2149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51077 BF_2 128.00 3.12 2003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5108 BF_2 11.91 0.76 947 344925805 BAK64379.1 391 2.8e-35 similar to amino acid transporter [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51081 BF_2 343.85 3.41 4510 642926793 XP_008195018.1 4220 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 73 5.38635e-27 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2506 3.1e-281 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF13606//PF00651//PF00023//PF01068 Ankyrin repeat//BTB/POZ domain//Ankyrin repeat//ATP dependent DNA ligase domain GO:0006281//GO:0006310//GO:0006260 DNA repair//DNA recombination//DNA replication GO:0005515//GO:0003910//GO:0005524 protein binding//DNA ligase (ATP) activity//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.51082 BF_2 35.30 0.40 3952 478256893 ENN77062.1 359 6.0e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 6.1e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF16622//PF02150//PF07975//PF13465//PF00096 HNH endonuclease//zinc-finger C2H2-type//RNA polymerases M/15 Kd subunit//TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006351//GO:0006281//GO:0006144//GO:0006206 transcription, DNA-templated//DNA repair//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0004519//GO:0003676//GO:0008270//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//endonuclease activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.51084 BF_2 30.92 1.10 1463 662192693 XP_008469216.1 150 3.8e-07 PREDICTED: uncharacterized protein LOC103506596 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51087 BF_2 22.33 0.33 3082 270003283 EEZ99730.1 288 8.1e-23 hypothetical protein TcasGA2_TC002499 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 -- -- -- -- PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.51090 BF_2 55.77 1.36 2000 642921483 XP_008192888.1 951 6.9e-100 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51091 BF_2 210.86 6.64 1616 642921483 XP_008192888.1 1043 1.2e-110 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTY1 209 2.5e-15 Monocarboxylate transporter 9 OS=Homo sapiens GN=SLC16A9 PE=1 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.51092 BF_2 295.23 2.39 5457 189238580 XP_971286.2 2127 8.1e-236 PREDICTED: protein mothers against dpp-like [Tribolium castaneum] 826414663 XM_012666571.1 155 1.70266e-72 PREDICTED: Monomorium pharaonis protein mothers against dpp (LOC105828307), transcript variant X2, mRNA K04676 SMAD1 mothers against decapentaplegic homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04676 P42003 1912 2.9e-212 Protein mothers against dpp OS=Drosophila melanogaster GN=Mad PE=1 SV=1 PF03165//PF01272//PF10401//PF03166 MH1 domain//Transcription elongation factor, GreA/GreB, C-term//Interferon-regulatory factor 3//MH2 domain GO:0032784//GO:0006355 regulation of DNA-templated transcription, elongation//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular KOG3701 TGFbeta receptor signaling protein SMAD and related proteins Cluster-8309.51094 BF_2 113.35 0.72 6883 642923817 XP_001816010.2 3150 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 2.62763e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q9NQC7 1133 7.7e-122 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens GN=CYLD PE=1 SV=1 PF00443//PF07297//PF01529//PF04451 Ubiquitin carboxyl-terminal hydrolase//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//DHHC palmitoyltransferase//Large eukaryotic DNA virus major capsid protein GO:0009059//GO:0016579 macromolecule biosynthetic process//protein deubiquitination GO:0036459//GO:0008270//GO:0005198 ubiquitinyl hydrolase activity//zinc ion binding//structural molecule activity GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.51096 BF_2 93.37 0.82 5047 642923817 XP_001816010.2 2743 2.8e-307 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 1.92393e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q9NQC7 1071 8.7e-115 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens GN=CYLD PE=1 SV=1 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG3556 Familial cylindromatosis protein Cluster-8309.51097 BF_2 97.26 3.97 1312 478253679 ENN73981.1 424 5.8e-39 hypothetical protein YQE_09436, partial [Dendroctonus ponderosae]>gi|546684423|gb|ERL94066.1| hypothetical protein D910_11349 [Dendroctonus ponderosae] -- -- -- -- -- K03861 PIGP, GPI19, DSCR5 phosphatidylinositol glycan, class P http://www.genome.jp/dbget-bin/www_bget?ko:K03861 Q9JHG1 231 5.7e-18 Phosphatidylinositol N-acetylglucosaminyltransferase subunit P OS=Mus musculus GN=Pigp PE=2 SV=1 PF07297//PF04451//PF01529 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Large eukaryotic DNA virus major capsid protein//DHHC palmitoyltransferase GO:0009059 macromolecule biosynthetic process GO:0005198//GO:0008270 structural molecule activity//zinc ion binding GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.51098 BF_2 234.62 3.72 2928 642921224 XP_008192769.1 1615 1.0e-176 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 303 4.84731e-155 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 2.5e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF13606//PF00023//PF14604//PF00018 Ankyrin repeat//Ankyrin repeat//Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.51105 BF_2 8.00 29.04 263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51106 BF_2 55.09 2.19 1341 270015218 EFA11666.1 601 1.8e-59 hypothetical protein TcasGA2_TC008530 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SXW3 280 1.2e-23 Leucine-rich repeat-containing protein 40 OS=Danio rerio GN=lrrc40 PE=2 SV=1 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.51107 BF_2 43.59 0.87 2386 642914567 XP_008190268.1 327 1.9e-27 PREDICTED: uncharacterized protein LOC103312147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51108 BF_2 4.00 0.36 757 195979063 ACG63697.1 1003 2.4e-106 myosin heavy chain [Gammarus duebeni] 410509305 AB758441.1 217 7.77768e-108 Penaeus monodon MYH1 mRNA for myosin heavy chain type 1, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 921 3.2e-98 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF00063 Myosin head (motor domain) -- -- GO:0003774//GO:0005524 motor activity//ATP binding GO:0016459 myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.51111 BF_2 21.47 0.48 2140 343183155 BAK61430.1 2733 1.7e-306 myosin heavy chain type b [Marsupenaeus japonicus] 343183154 AB613206.1 785 0 Marsupenaeus japonicus MYHb mRNA for myosin heavy chain type b, complete cds K17751 MYH6_7 myosin heavy chain 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K17751 P05661 2430 9.6e-273 Myosin heavy chain, muscle OS=Drosophila melanogaster GN=Mhc PE=1 SV=4 PF01059//PF00063//PF02736//PF04799 NADH-ubiquinone oxidoreductase chain 4, amino terminus//Myosin head (motor domain)//Myosin N-terminal SH3-like domain//fzo-like conserved region GO:0008053//GO:0055114//GO:0006120 mitochondrial fusion//oxidation-reduction process//mitochondrial electron transport, NADH to ubiquinone GO:0003774//GO:0005524//GO:0003924 motor activity//ATP binding//GTPase activity GO:0005741//GO:0016021//GO:0016459 mitochondrial outer membrane//integral component of membrane//myosin complex KOG0161 Myosin class II heavy chain Cluster-8309.51115 BF_2 50.98 40.84 332 478257525 ENN77680.1 162 3.5e-09 hypothetical protein YQE_05831, partial [Dendroctonus ponderosae]>gi|546677868|gb|ERL88620.1| hypothetical protein D910_06005 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51120 BF_2 156.00 16.53 682 478256423 ENN76610.1 428 1.0e-39 hypothetical protein YQE_06868, partial [Dendroctonus ponderosae] -- -- -- -- -- K17292 TBCA tubulin-specific chaperone A http://www.genome.jp/dbget-bin/www_bget?ko:K17292 Q6PEC1 330 9.8e-30 Tubulin-specific chaperone A OS=Rattus norvegicus GN=Tbca PE=1 SV=1 PF02970 Tubulin binding cofactor A GO:0007021 tubulin complex assembly GO:0051082//GO:0015631 unfolded protein binding//tubulin binding GO:0045298 tubulin complex KOG3470 Beta-tubulin folding cofactor A Cluster-8309.51125 BF_2 95.12 2.72 1751 546671410 ERL83733.1 739 2.3e-75 hypothetical protein D910_00946 [Dendroctonus ponderosae]>gi|546671482|gb|ERL83777.1| hypothetical protein D910_01015 [Dendroctonus ponderosae]>gi|546671488|gb|ERL83781.1| hypothetical protein D910_01019 [Dendroctonus ponderosae] -- -- -- -- -- K10990 RMI1, BRAP75 RecQ-mediated genome instability protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10990 Q7ZVM9 410 1.3e-38 RecQ-mediated genome instability protein 1 OS=Danio rerio GN=rmi1 PE=2 SV=1 PF16099 Recq-mediated genome instability protein 1, C-terminal OB-fold -- -- GO:0000166 nucleotide binding -- -- KOG3683 Uncharacterized conserved protein Cluster-8309.51126 BF_2 31.05 0.57 2550 642926818 XP_001810169.2 1787 1.0e-196 PREDICTED: uncharacterized protein LOC100142170 isoform X1 [Tribolium castaneum] 642926819 XM_008196805.1 195 4.59036e-95 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096 Altered inheritance of mitochondria protein 3 GO:0051016 barbed-end actin filament capping -- -- GO:0030479 actin cortical patch -- -- Cluster-8309.51127 BF_2 296.00 18.85 944 478257864 ENN78006.1 605 4.3e-60 hypothetical protein YQE_05526, partial [Dendroctonus ponderosae]>gi|546674575|gb|ERL85928.1| hypothetical protein D910_03343 [Dendroctonus ponderosae] -- -- -- -- -- K17432 MRPL51 large subunit ribosomal protein L51 http://www.genome.jp/dbget-bin/www_bget?ko:K17432 Q29PG4 514 6.3e-51 39S ribosomal protein L51, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL51 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4045 Uncharacterized conserved protein Cluster-8309.51129 BF_2 85.09 1.10 3513 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 6.8e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF05504//PF00233//PF09771//PF00989//PF00072 Spore germination B3/ GerAC like, C-terminal//3'5'-cyclic nucleotide phosphodiesterase//Transmembrane protein 188//PAS fold//Response regulator receiver domain GO:0009847//GO:0006355//GO:0006144//GO:0007165//GO:0035307//GO:0000160 spore germination//regulation of transcription, DNA-templated//purine nucleobase metabolic process//signal transduction//positive regulation of protein dephosphorylation//phosphorelay signal transduction system GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.51132 BF_2 3.00 0.33 662 470012454 AGI03918.1 281 1.1e-22 60S ribosomal protein L4-like protein, partial [Leptinotarsa decemlineata] -- -- -- -- -- K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P09180 192 9.6e-14 60S ribosomal protein L4 OS=Drosophila melanogaster GN=RpL4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.51133 BF_2 8.00 0.44 1054 805766866 XP_012135376.1 388 7.0e-35 PREDICTED: uncharacterized protein LOC105661843 [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.51136 BF_2 38.89 1.13 1721 91088311 XP_969566.1 619 1.9e-61 PREDICTED: dipeptidase 1 [Tribolium castaneum]>gi|270012164|gb|EFA08612.1| hypothetical protein TcasGA2_TC006275 [Tribolium castaneum] -- -- -- -- -- K01273 DPEP membrane dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01273 O59832 455 8.0e-44 Uncharacterized dipeptidase C965.12 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPCC965.12 PE=3 SV=1 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805//GO:0008238 dipeptidase activity//exopeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.51139 BF_2 354.24 2.82 5545 546676831 ERL87777.1 1250 4.1e-134 hypothetical protein D910_05166 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DCD5 235 8.3e-18 Tight junction-associated protein 1 OS=Mus musculus GN=Tjap1 PE=1 SV=1 PF01890 Cobalamin synthesis G C-terminus GO:0009236 cobalamin biosynthetic process -- -- -- -- -- -- Cluster-8309.51141 BF_2 17.03 0.34 2384 642915063 XP_008190394.1 636 2.8e-63 PREDICTED: acyl-CoA dehydrogenase family member 9, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JZN5 252 3.8e-20 Acyl-CoA dehydrogenase family member 9, mitochondrial OS=Mus musculus GN=Acad9 PE=1 SV=2 PF09057//PF00926//PF02770//PF02771 Second Mitochondria-derived Activator of Caspases//3,4-dihydroxy-2-butanone 4-phosphate synthase//Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain GO:0055114//GO:0006915//GO:0006118//GO:0006919//GO:0009231//GO:0008152 oxidation-reduction process//apoptotic process//obsolete electron transport//activation of cysteine-type endopeptidase activity involved in apoptotic process//riboflavin biosynthetic process//metabolic process GO:0016627//GO:0050660//GO:0003995//GO:0008686 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//3,4-dihydroxy-2-butanone-4-phosphate synthase activity GO:0005739 mitochondrion KOG0137 Very-long-chain acyl-CoA dehydrogenase Cluster-8309.51146 BF_2 202.11 2.76 3349 91080057 XP_973322.1 1545 1.5e-168 PREDICTED: GDP-mannose 4,6 dehydratase [Tribolium castaneum]>gi|270004634|gb|EFA01082.1| hypothetical protein TcasGA2_TC004005 [Tribolium castaneum] 817222766 XM_012431305.1 132 6.35185e-60 PREDICTED: Orussus abietinus GDP-mannose 4,6 dehydratase-like (LOC105703151), mRNA K01711 gmd, GMDS GDPmannose 4,6-dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01711 Q9VMW9 1386 1.7e-151 GDP-mannose 4,6 dehydratase OS=Drosophila melanogaster GN=Gmd PE=1 SV=2 PF04814//PF01370 Hepatocyte nuclear factor 1 (HNF-1), N terminus//NAD dependent epimerase/dehydratase family GO:0009298//GO:0006012//GO:0019673//GO:0045893//GO:0006000 GDP-mannose biosynthetic process//galactose metabolic process//GDP-mannose metabolic process//positive regulation of transcription, DNA-templated//fructose metabolic process GO:0050662//GO:0003824//GO:0000166//GO:0008446 coenzyme binding//catalytic activity//nucleotide binding//GDP-mannose 4,6-dehydratase activity GO:0005634//GO:0005622 nucleus//intracellular KOG1372 GDP-mannose 4,6 dehydratase Cluster-8309.51148 BF_2 361.66 11.87 1562 642924915 XP_008194095.1 1347 6.5e-146 PREDICTED: neprilysin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01415 ECE endothelin-converting enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K01415 O16796 719 1.8e-74 Neprilysin-11 OS=Caenorhabditis elegans GN=nep-11 PE=1 SV=2 PF01431 Peptidase family M13 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- KOG3624 M13 family peptidase Cluster-8309.51150 BF_2 228.18 1.35 7383 189234456 XP_968035.2 3830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 2.17964e-112 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 2695 6.2e-303 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF00454 Phosphatidylinositol 3- and 4-kinase GO:0036092//GO:0046854//GO:0048015 phosphatidylinositol-3-phosphate biosynthetic process//phosphatidylinositol phosphorylation//phosphatidylinositol-mediated signaling GO:0016303//GO:0005524//GO:0016773 1-phosphatidylinositol-3-kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.51153 BF_2 3.00 8.65 271 642089788 CDQ82427.1 332 5.6e-29 unnamed protein product [Oncorhynchus mykiss] 393395827 JQ824131.1 265 5.3134e-135 Scylla paramamosain elongation factor 2 mRNA, complete cds K03234 EEF2 elongation factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03234 P29691 317 1.3e-28 Elongation factor 2 OS=Caenorhabditis elegans GN=eef-2 PE=2 SV=4 PF01926 50S ribosome-binding GTPase -- -- GO:0005525 GTP binding -- -- KOG0469 Elongation factor 2 Cluster-8309.51157 BF_2 44.70 0.90 2374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51159 BF_2 8.00 0.43 1068 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00682 HMGL-like -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.5116 BF_2 23.00 0.34 3123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51161 BF_2 171.82 1.58 4827 546687608 ERL96229.1 1695 8.9e-186 hypothetical protein D910_01506 [Dendroctonus ponderosae]>gi|546687612|gb|ERL96230.1| hypothetical protein D910_01507 [Dendroctonus ponderosae] 817204838 XM_012422887.1 468 0 PREDICTED: Orussus abietinus stress-activated protein kinase JNK (LOC105698550), transcript variant X5, mRNA K04440 JNK c-Jun N-terminal kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04440 P92208 1555 6.3e-171 Stress-activated protein kinase JNK OS=Drosophila melanogaster GN=bsk PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane -- -- Cluster-8309.51164 BF_2 2.08 0.39 511 546686084 ERL95484.1 407 2.1e-37 hypothetical protein D910_12746 [Dendroctonus ponderosae] -- -- -- -- -- K00289 E1.5.1.6, FTHFD formyltetrahydrofolate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00289 Q63ZT8 271 5.1e-23 Cytosolic 10-formyltetrahydrofolate dehydrogenase OS=Xenopus tropicalis GN=aldh1l1 PE=2 SV=1 PF00551 Formyl transferase GO:0009058 biosynthetic process GO:0016742 hydroxymethyl-, formyl- and related transferase activity -- -- KOG2452 Formyltetrahydrofolate dehydrogenase Cluster-8309.51165 BF_2 191.73 1.13 7397 642918516 XP_008191506.1 2857 0.0e+00 PREDICTED: angiopoietin-4 [Tribolium castaneum] 755982309 XM_011311561.1 246 5.98645e-123 PREDICTED: Fopius arisanus angiopoietin-related protein 2 (LOC105270540), mRNA -- -- -- -- Q9U8W7 556 6.7e-55 Techylectin-5B OS=Tachypleus tridentatus PE=1 SV=1 PF08336//PF05615//PF04111//PF00137//PF04513//PF08702 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Tho complex subunit 7//Autophagy protein Apg6//ATP synthase subunit C//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family GO:0006914//GO:0051258//GO:0018401//GO:0007165//GO:0006525//GO:0015992//GO:0055114//GO:0006560//GO:0015991//GO:0006397//GO:0030168 autophagy//protein polymerization//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//signal transduction//arginine metabolic process//proton transport//oxidation-reduction process//proline metabolic process//ATP hydrolysis coupled proton transport//mRNA processing//platelet activation GO:0005198//GO:0016702//GO:0005102//GO:0015078//GO:0004656//GO:0030674 structural molecule activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//receptor binding//hydrogen ion transmembrane transporter activity//procollagen-proline 4-dioxygenase activity//protein binding, bridging GO:0033177//GO:0019028//GO:0005577//GO:0000445//GO:0005783//GO:0019031 proton-transporting two-sector ATPase complex, proton-transporting domain//viral capsid//fibrinogen complex//THO complex part of transcription export complex//endoplasmic reticulum//viral envelope KOG0233 Vacuolar H+-ATPase V0 sector, subunit c'' Cluster-8309.51174 BF_2 119.39 0.56 9162 642918201 XP_008191408.1 10448 0.0e+00 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918206 XM_008193189.1 808 0 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X4, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 Q15911 1905 3.1e-211 Zinc finger homeobox protein 3 OS=Homo sapiens GN=ZFHX3 PE=1 SV=2 PF00096//PF04988//PF00046//PF13912//PF01435//PF05920//PF13411 Zinc finger, C2H2 type//A-kinase anchoring protein 95 (AKAP95)//Homeobox domain//C2H2-type zinc finger//Peptidase family M48//Homeobox KN domain//MerR HTH family regulatory protein GO:0006355//GO:0006508 regulation of transcription, DNA-templated//proteolysis GO:0004222//GO:0003677//GO:0046872 metalloendopeptidase activity//DNA binding//metal ion binding GO:0005634 nucleus KOG1146 Homeobox protein Cluster-8309.51175 BF_2 30.31 0.51 2772 642919246 XP_008191792.1 510 1.3e-48 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 312 4.9e-27 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51177 BF_2 121.83 0.74 7178 589968018 XP_006996507.1 370 5.8e-32 PREDICTED: zinc finger protein 431-like [Peromyscus maniculatus bairdii] -- -- -- -- -- -- -- -- -- Q9UJN7 345 1.9e-30 Zinc finger protein 391 OS=Homo sapiens GN=ZNF391 PE=2 SV=2 PF02724//PF13912//PF09606//PF08452//PF13465//PF00096//PF00508 CDC45-like protein//C2H2-type zinc finger//ARC105 or Med15 subunit of Mediator complex non-fungal//DNA polymerase family B exonuclease domain, N-terminal//Zinc-finger double domain//Zinc finger, C2H2 type//E2 (early) protein, N terminal GO:0006260//GO:0006357//GO:0006355//GO:0016032//GO:0006275//GO:0006270 DNA replication//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//viral process//regulation of DNA replication//DNA replication initiation GO:0046872//GO:0001104//GO:0003887 metal ion binding//RNA polymerase II transcription cofactor activity//DNA-directed DNA polymerase activity GO:0016592//GO:0042575 mediator complex//DNA polymerase complex -- -- Cluster-8309.51178 BF_2 52.32 1.13 2232 672017838 XP_008773853.1 392 5.1e-35 PREDICTED: zinc finger protein 431-like isoform X1 [Rattus norvegicus] -- -- -- -- -- -- -- -- -- P51522 368 1.3e-33 Zinc finger protein 83 OS=Homo sapiens GN=ZNF83 PE=2 SV=3 PF11744//PF00096//PF13465//PF13912//PF02724//PF01428 Aluminium activated malate transporter//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//CDC45-like protein//AN1-like Zinc finger GO:0015743//GO:0006270 malate transport//DNA replication initiation GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.51179 BF_2 72.52 0.54 5889 189239140 XP_001806913.1 1267 4.6e-136 PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|642928372|ref|XP_008192716.1| PREDICTED: protein bunched, class 2/F/G isoform [Tribolium castaneum]>gi|270010787|gb|EFA07235.1| hypothetical protein TcasGA2_TC010592 [Tribolium castaneum] 657809175 XM_008333639.1 51 1.19594e-14 PREDICTED: Cynoglossus semilaevis TSC22 domain family protein 2-like (LOC103395840), transcript variant X2, mRNA -- -- -- -- Q24523 204 3.5e-14 Protein bunched, class 2/F/G isoform OS=Drosophila melanogaster GN=bun PE=2 SV=4 PF04977//PF06156//PF01486//PF00170//PF06005//PF01166//PF07926//PF04799//PF11365//PF00038//PF07716 Septum formation initiator//Protein of unknown function (DUF972)//K-box region//bZIP transcription factor//Protein of unknown function (DUF904)//TSC-22/dip/bun family//TPR/MLP1/MLP2-like protein//fzo-like conserved region//Protein of unknown function (DUF3166)//Intermediate filament protein//Basic region leucine zipper GO:0043093//GO:0000917//GO:0008053//GO:0010506//GO:0007049//GO:0006260//GO:0006355//GO:0006606 FtsZ-dependent cytokinesis//barrier septum assembly//mitochondrial fusion//regulation of autophagy//cell cycle//DNA replication//regulation of transcription, DNA-templated//protein import into nucleus GO:0003924//GO:0005198//GO:0003700//GO:0043565 GTPase activity//structural molecule activity//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634//GO:0005741//GO:0005882//GO:0016021//GO:0005737//GO:0005615 transcription factor complex//nucleus//mitochondrial outer membrane//intermediate filament//integral component of membrane//cytoplasm//extracellular space KOG4797 Transcriptional regulator Cluster-8309.51180 BF_2 14.00 1.74 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51183 BF_2 27.84 1.62 1006 642914452 XP_008201682.1 831 2.9e-86 PREDICTED: GRAM domain-containing protein 1B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR37 180 3.6e-12 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51184 BF_2 465.75 8.35 2621 91077778 XP_969102.1 2335 3.0e-260 PREDICTED: GRAM domain-containing protein 1B-like isoform X1 [Tribolium castaneum]>gi|642914450|ref|XP_008201680.1| PREDICTED: GRAM domain-containing protein 1B-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3KR37 875 2.4e-92 GRAM domain-containing protein 1B OS=Homo sapiens GN=GRAMD1B PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1032 Uncharacterized conserved protein, contains GRAM domain Cluster-8309.51193 BF_2 45.77 1.56 1515 817011233 AKF11870.1 588 6.5e-58 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR6 492 3.6e-48 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.51194 BF_2 276.58 14.97 1060 817011233 AKF11870.1 903 1.3e-94 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR5 644 6.0e-66 Juvenile hormone epoxide hydrolase 2 OS=Ctenocephalides felis GN=EH2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.51195 BF_2 219.00 3.68 2774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168//PF03574 Triple QxxK/R motif-containing protein family//Peptidase family S48 GO:0043158 heterocyst differentiation GO:0004252//GO:0003677 serine-type endopeptidase activity//DNA binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.51196 BF_2 258.00 8.31 1586 332374160 AEE62221.1 385 2.3e-34 unknown [Dendroctonus ponderosae]>gi|546682250|gb|ERL92211.1| hypothetical protein D910_09531 [Dendroctonus ponderosae] -- -- -- -- -- K18178 COA5, PET191 cytochrome c oxidase assembly factor 5 http://www.genome.jp/dbget-bin/www_bget?ko:K18178 A1L3N6 221 1.0e-16 Cytochrome c oxidase assembly factor 5 OS=Xenopus laevis GN=coa5 PE=3 SV=1 PF04706 Dickkopf N-terminal cysteine-rich region GO:0030178//GO:0007275 negative regulation of Wnt signaling pathway//multicellular organismal development -- -- GO:0005576 extracellular region KOG4114 Cytochrome c oxidase assembly protein PET191 Cluster-8309.51197 BF_2 46.68 0.62 3433 642918916 XP_008191654.1 4139 0.0e+00 PREDICTED: apoptosis-resistant E3 ubiquitin protein ligase 1 isoform X1 [Tribolium castaneum] 194759777 XM_001962088.1 63 1.48137e-21 Drosophila ananassae GF14596 (Dana\GF14596), mRNA -- -- -- -- O15033 1602 1.6e-176 Apoptosis-resistant E3 ubiquitin protein ligase 1 OS=Homo sapiens GN=AREL1 PE=1 SV=3 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0939 E3 ubiquitin-protein ligase/Putative upstream regulatory element binding protein Cluster-8309.51204 BF_2 416.08 2.80 6505 270000847 EEZ97294.1 1566 1.1e-170 hypothetical protein TcasGA2_TC011099 [Tribolium castaneum] 642937258 XM_008200538.1 171 2.59019e-81 PREDICTED: Tribolium castaneum mucin-2 (LOC657242), mRNA -- -- -- -- -- -- -- -- PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.51208 BF_2 379.00 5.77 3035 642920202 XP_008192247.1 1933 1.4e-213 PREDICTED: uncharacterized protein LOC103312691 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06455 NADH dehydrogenase subunit 5 C-terminus GO:0006814//GO:0042773//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ATP synthesis coupled electron transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-8309.51209 BF_2 292.13 3.74 3552 546683281 ERL93113.1 1368 5.4e-148 hypothetical protein D910_10415 [Dendroctonus ponderosae] 755951009 XM_011303317.1 181 3.88846e-87 PREDICTED: Fopius arisanus liprin-alpha-1 (LOC105265686), transcript variant X11, mRNA -- -- -- -- Q13136 1133 4.0e-122 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF00884//PF01663//PF02247//PF07647//PF03294//PF00536 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//Large coat protein//SAM domain (Sterile alpha motif)//RNA polymerase-associated transcription specificity factor, Rap94//SAM domain (Sterile alpha motif) GO:0008152 metabolic process GO:0003700//GO:0008484//GO:0005198//GO:0005515//GO:0003824 transcription factor activity, sequence-specific DNA binding//sulfuric ester hydrolase activity//structural molecule activity//protein binding//catalytic activity GO:0005667//GO:0019028 transcription factor complex//viral capsid KOG0249 LAR-interacting protein and related proteins Cluster-8309.51210 BF_2 37.60 0.32 5244 642912405 XP_008199494.1 3145 0.0e+00 PREDICTED: liprin-alpha-1 isoform X12 [Tribolium castaneum] 642912388 XM_008201264.1 777 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X4, mRNA -- -- -- -- Q13136 1554 8.9e-171 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF05513//PF15724 TraA//TMEM119 family GO:0000746//GO:0001503 conjugation//ossification -- -- GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.51215 BF_2 33.65 0.31 4824 91078392 XP_974372.1 1555 1.5e-169 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270003986|gb|EFA00434.1| hypothetical protein TcasGA2_TC003288 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7PIR5 594 1.7e-59 Facilitated trehalose transporter Tret1 OS=Anopheles gambiae GN=Tret1 PE=1 SV=3 PF02086//PF00083//PF07690//PF01770 D12 class N6 adenine-specific DNA methyltransferase//Sugar (and other) transporter//Major Facilitator Superfamily//Reduced folate carrier GO:0032775//GO:0055085//GO:0006810//GO:0006306 DNA methylation on adenine//transmembrane transport//transport//DNA methylation GO:0022857//GO:0009007 transmembrane transporter activity//site-specific DNA-methyltransferase (adenine-specific) activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.51217 BF_2 34.73 0.95 1809 546676350 ERL87377.1 1897 1.3e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.0e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.5122 BF_2 76.98 4.64 981 546671056 ERL83540.1 991 7.8e-105 hypothetical protein D910_00610 [Dendroctonus ponderosae] -- -- -- -- -- K12586 RRP43, EXOSC8, OIP2 exosome complex component RRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12586 Q96B26 734 2.0e-76 Exosome complex component RRP43 OS=Homo sapiens GN=EXOSC8 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.51220 BF_2 447.00 4.33 4605 642923960 XP_970859.2 718 1.7e-72 PREDICTED: neural Wiskott-Aldrich syndrome protein [Tribolium castaneum]>gi|642923962|ref|XP_008193941.1| PREDICTED: neural Wiskott-Aldrich syndrome protein [Tribolium castaneum]>gi|642923964|ref|XP_008193942.1| PREDICTED: neural Wiskott-Aldrich syndrome protein [Tribolium castaneum] -- -- -- -- -- K05747 WAS Wiskott-Aldrich syndrome protein http://www.genome.jp/dbget-bin/www_bget?ko:K05747 Q91YD9 401 3.9e-37 Neural Wiskott-Aldrich syndrome protein OS=Mus musculus GN=Wasl PE=1 SV=1 PF06105//PF02205 Aph-1 protein//WH2 motif GO:0043085//GO:0016485 positive regulation of catalytic activity//protein processing GO:0003779 actin binding GO:0016021 integral component of membrane KOG3671 Actin regulatory protein (Wiskott-Aldrich syndrome protein) Cluster-8309.51222 BF_2 88.12 1.35 3014 190702371 ACE75264.1 1760 1.6e-193 DNA Pol B2 domain-containing protein [Glyptapanteles flavicoxis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51226 BF_2 7.91 0.34 1263 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51227 BF_2 639.25 2.27 12053 270016002 EFA12450.1 1111 1.2e-117 hypothetical protein TcasGA2_TC016185 [Tribolium castaneum]>gi|270016905|gb|EFA13351.1| hypothetical protein TcasGA2_TC006959 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 315 9.6e-27 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF13683//PF08398//PF00770//PF01637//PF02902//PF00665//PF02022 Integrase core domain//Parvovirus coat protein VP1//Adenovirus endoprotease//Archaeal ATPase//Ulp1 protease family, C-terminal catalytic domain//Integrase core domain//Integrase Zinc binding domain GO:0006508//GO:0015074 proteolysis//DNA integration GO:0008270//GO:0008234//GO:0004197//GO:0005524//GO:0005198 zinc ion binding//cysteine-type peptidase activity//cysteine-type endopeptidase activity//ATP binding//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.51229 BF_2 5.00 0.42 787 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51230 BF_2 19.00 0.54 1748 -- -- -- -- -- 642923663 XM_008195611.1 51 3.50126e-15 PREDICTED: Tribolium castaneum acetylcholinesterase 1 (LOC662258), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51232 BF_2 81.51 5.87 868 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51235 BF_2 258.85 2.14 5352 478258110 ENN78248.1 2446 8.2e-273 hypothetical protein YQE_05399, partial [Dendroctonus ponderosae] 642929289 XM_967942.2 246 4.32527e-123 PREDICTED: Tribolium castaneum nucleoporin SEH1 (LOC661803), mRNA K01254 LTA4H leukotriene-A4 hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01254 P09960 1489 3.1e-163 Leukotriene A-4 hydrolase OS=Homo sapiens GN=LTA4H PE=1 SV=2 PF01435//PF00400//PF08063//PF09127//PF01433 Peptidase family M48//WD domain, G-beta repeat//PADR1 (NUC008) domain//Leukotriene A4 hydrolase, C-terminal//Peptidase family M1 GO:0006508//GO:0019370 proteolysis//leukotriene biosynthetic process GO:0004222//GO:0005515//GO:0008237//GO:0008270//GO:0003950 metalloendopeptidase activity//protein binding//metallopeptidase activity//zinc ion binding//NAD+ ADP-ribosyltransferase activity GO:0005634 nucleus KOG1047 Bifunctional leukotriene A4 hydrolase/aminopeptidase LTA4H Cluster-8309.51240 BF_2 25.73 0.42 2851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08923//PF04153 Mitogen-activated protein kinase kinase 1 interacting//NOT2 / NOT3 / NOT5 family GO:0006355//GO:0032006 regulation of transcription, DNA-templated//regulation of TOR signaling -- -- GO:0005634 nucleus -- -- Cluster-8309.51242 BF_2 56.50 0.51 4917 478252787 ENN73180.1 1289 1.1e-138 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 5.6e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4780 Uncharacterized conserved protein Cluster-8309.51246 BF_2 4.00 0.56 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51249 BF_2 184.56 1.67 4901 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.1e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0055085//GO:0006821 transmembrane transport//chloride transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.51250 BF_2 179.72 1.58 5047 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.2e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.51251 BF_2 579.70 3.31 7620 780669493 XP_011694869.1 1341 1.6e-144 PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata]>gi|780669497|ref|XP_011694870.1| PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata]>gi|780669501|ref|XP_011694871.1| PREDICTED: methylcytosine dioxygenase TET2 isoform X1 [Wasmannia auropunctata] 642922119 XM_008194802.1 71 1.18058e-25 PREDICTED: Tribolium castaneum uncharacterized LOC103312925 (LOC103312925), mRNA -- -- -- -- M9NEY8 1073 7.7e-115 DNA N6-methyl adenine demethylase OS=Drosophila melanogaster GN=Tet PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51254 BF_2 65.95 0.60 4882 642931654 XP_008196673.1 2383 1.5e-265 PREDICTED: rap1 GTPase-activating protein 1 isoform X1 [Tribolium castaneum] 642931660 XM_008198455.1 92 1.59934e-37 PREDICTED: Tribolium castaneum rap1 GTPase-activating protein 1 (LOC661653), transcript variant X5, mRNA K17700 RAP1GAP, RAPGAP RAP1 GTPase activating protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17700 P47736 1108 4.3e-119 Rap1 GTPase-activating protein 1 OS=Homo sapiens GN=RAP1GAP PE=1 SV=2 PF07836//PF02145//PF02188//PF13851 DmpG-like communication domain//Rap/ran-GAP//GoLoco motif//Growth-arrest specific micro-tubule binding GO:0048870//GO:0019439//GO:0051056 cell motility//aromatic compound catabolic process//regulation of small GTPase mediated signal transduction GO:0016833//GO:0030695//GO:0005096 oxo-acid-lyase activity//GTPase regulator activity//GTPase activator activity GO:0031514 motile cilium KOG3686 Rap1-GTPase-activating protein (Rap1GAP) Cluster-8309.51261 BF_2 20.62 0.58 1778 38048055 AAR09930.1 175 5.9e-10 similar to Drosophila melanogaster Rab1, partial [Drosophila yakuba] -- -- -- -- -- K07874 RAB1A Ras-related protein Rab-1A http://www.genome.jp/dbget-bin/www_bget?ko:K07874 Q9ZRE2 174 3.2e-11 Ras-related protein RABD1 OS=Arabidopsis thaliana GN=RABD1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0084 GTPase Rab1/YPT1, small G protein superfamily, and related GTP-binding proteins Cluster-8309.51263 BF_2 294.61 6.27 2253 255958232 NP_001157646.1 2114 1.1e-234 matrix metalloproteinase 1 isoform 1 precursor [Tribolium castaneum]>gi|270008219|gb|EFA04667.1| matrix metalloproteinase 1 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q10739 816 1.4e-85 Matrix metalloproteinase-14 OS=Rattus norvegicus GN=Mmp14 PE=2 SV=2 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0004222//GO:0005509//GO:0008270 metalloendopeptidase activity//calcium ion binding//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.51264 BF_2 639.25 15.54 2008 91090500 XP_969356.1 1185 5.1e-127 PREDICTED: shootin-1 [Tribolium castaneum]>gi|642935361|ref|XP_008197981.1| PREDICTED: shootin-1 [Tribolium castaneum]>gi|270013357|gb|EFA09805.1| hypothetical protein TcasGA2_TC011950 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0MZ66 206 7.0e-15 Shootin-1 OS=Homo sapiens GN=KIAA1598 PE=1 SV=4 PF17078//PF00435//PF05531//PF04728 SWI5-dependent HO expression protein 3//Spectrin repeat//Nucleopolyhedrovirus P10 protein//Lipoprotein leucine-zipper GO:0051028//GO:0048309 mRNA transport//endoplasmic reticulum inheritance GO:0005515 protein binding GO:0019028//GO:0019867 viral capsid//outer membrane -- -- Cluster-8309.51267 BF_2 484.90 12.52 1907 642920075 XP_008192196.1 1581 5.8e-173 PREDICTED: gephyrin isoform X1 [Tribolium castaneum] -- -- -- -- -- K15376 GPHN gephyrin http://www.genome.jp/dbget-bin/www_bget?ko:K15376 P39205 970 1.7e-103 Molybdenum cofactor synthesis protein cinnamon OS=Drosophila melanogaster GN=cin PE=1 SV=3 PF03454//PF03453 MoeA C-terminal region (domain IV)//MoeA N-terminal region (domain I and II) GO:0032324 molybdopterin cofactor biosynthetic process -- -- -- -- KOG2371 Molybdopterin biosynthesis protein Cluster-8309.51268 BF_2 1.00 23.57 213 3907620 AAC78681.1 365 6.6e-33 actin 1 [Penaeus monodon] 3907621 AF100987.1 162 7.3113e-78 AF100987 Penaeus monodon actin 2 (act2) mRNA, complete cds K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 O16808 360 1.0e-33 Actin OS=Mayetiola destructor PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.51274 BF_2 38.00 0.77 2346 478251119 ENN71595.1 1727 8.4e-190 hypothetical protein YQE_11694, partial [Dendroctonus ponderosae] -- -- -- -- -- K10727 CDT1 chromatin licensing and DNA replication factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10727 Q9I9A7 731 1.1e-75 DNA replication factor Cdt1 OS=Xenopus laevis GN=cdt1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG4762 DNA replication factor Cluster-8309.51277 BF_2 20.00 1.66 790 546682659 ERL92571.1 354 4.6e-31 hypothetical protein D910_09884, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02724//PF06459//PF06783 CDC45-like protein//Ryanodine Receptor TM 4-6//Uncharacterised protein family (UPF0239) GO:0006270//GO:0006874//GO:0006816 DNA replication initiation//cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0005622//GO:0016021 intracellular//integral component of membrane -- -- Cluster-8309.51278 BF_2 1167.16 21.35 2574 642920590 XP_008192477.1 730 3.8e-74 PREDICTED: uncharacterized protein LOC661718 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 588 4.5e-59 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.51279 BF_2 260.49 2.98 3939 332375210 AEE62746.1 1041 5.0e-110 unknown [Dendroctonus ponderosae]>gi|478254335|gb|ENN74587.1| hypothetical protein YQE_08710, partial [Dendroctonus ponderosae]>gi|546674053|gb|ERL85541.1| hypothetical protein D910_02960 [Dendroctonus ponderosae] -- -- -- -- -- K02895 RP-L24, MRPL24, rplX large subunit ribosomal protein L24 http://www.genome.jp/dbget-bin/www_bget?ko:K02895 Q29MA5 828 1.0e-86 Probable 39S ribosomal protein L24, mitochondrial OS=Drosophila pseudoobscura pseudoobscura GN=mRpL24 PE=3 SV=1 PF13482 RNase_H superfamily -- -- GO:0003676 nucleic acid binding -- -- KOG3801 Uncharacterized conserved protein BCN92 Cluster-8309.51282 BF_2 63.02 1.50 2045 642928561 XP_008199958.1 1350 3.8e-146 PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928563|ref|XP_008199959.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|642928565|ref|XP_008199960.1| PREDICTED: probable cytochrome P450 12c1, mitochondrial isoform X1 [Tribolium castaneum]>gi|270011133|gb|EFA07581.1| cytochrome P450 12H1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V6D6 869 9.4e-92 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF02959//PF00067 HTLV Tax//Cytochrome P450 GO:0045893//GO:0055114 positive regulation of transcription, DNA-templated//oxidation-reduction process GO:0016705//GO:0005488//GO:0005506//GO:0016491//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding//iron ion binding//oxidoreductase activity//heme binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.51283 BF_2 27.14 1.43 1082 91092264 XP_967363.1 701 3.6e-71 PREDICTED: peptide deformylase, mitochondrial [Tribolium castaneum]>gi|270001218|gb|EEZ97665.1| hypothetical protein TcasGA2_TC016210 [Tribolium castaneum] -- -- -- -- -- K01462 PDF, def peptide deformylase http://www.genome.jp/dbget-bin/www_bget?ko:K01462 Q9HBH1 388 2.9e-36 Peptide deformylase, mitochondrial OS=Homo sapiens GN=PDF PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3137 Peptide deformylase Cluster-8309.51285 BF_2 56.04 0.61 4120 642926608 XP_969412.2 812 1.9e-83 PREDICTED: histone-lysine N-methyltransferase pr-set7 [Tribolium castaneum] -- -- -- -- -- K11428 SETD8 histone-lysine N-methyltransferase SETD8 http://www.genome.jp/dbget-bin/www_bget?ko:K11428 Q9VFK6 626 2.8e-63 Histone-lysine N-methyltransferase pr-set7 OS=Drosophila melanogaster GN=pr-set7 PE=1 SV=2 PF07571//PF00856 TAF6 C-terminal HEAT repeat domain//SET domain GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0005515 protein binding GO:0005634 nucleus KOG1085 Predicted methyltransferase (contains a SET domain) Cluster-8309.51287 BF_2 18.00 0.55 1664 675880570 XP_009025787.1 646 1.3e-64 hypothetical protein HELRODRAFT_163757 [Helobdella robusta]>gi|555693431|gb|ESN96663.1| hypothetical protein HELRODRAFT_163757 [Helobdella robusta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51296 BF_2 128.12 7.33 1018 189238253 XP_001813297.1 1260 5.2e-136 PREDICTED: GPN-loop GTPase 3 [Tribolium castaneum]>gi|270008652|gb|EFA05100.1| hypothetical protein TcasGA2_TC015199 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9D3W4 830 1.6e-87 GPN-loop GTPase 3 OS=Mus musculus GN=Gpn3 PE=2 SV=1 PF00004//PF00910//PF00005//PF01926 ATPase family associated with various cellular activities (AAA)//RNA helicase//ABC transporter//50S ribosome-binding GTPase -- -- GO:0003724//GO:0005524//GO:0000166//GO:0005525//GO:0003723//GO:0016887 RNA helicase activity//ATP binding//nucleotide binding//GTP binding//RNA binding//ATPase activity -- -- KOG1534 Putative transcription factor FET5 Cluster-8309.51297 BF_2 93.58 1.29 3327 556993813 XP_006001025.1 197 3.1e-12 PREDICTED: zinc finger protein 729-like [Latimeria chalumnae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5T619 185 3.1e-12 Zinc finger protein 648 OS=Homo sapiens GN=ZNF648 PE=2 SV=1 PF00096//PF13465//PF01155//PF07975//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//TFIIH C1-like domain//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006281//GO:0006464 DNA repair//cellular protein modification process GO:0046872//GO:0016151//GO:0008270 metal ion binding//nickel cation binding//zinc ion binding -- -- -- -- Cluster-8309.51299 BF_2 23.07 4.14 520 642926212 XP_008194831.1 306 1.1e-25 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926214|ref|XP_008194832.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926216|ref|XP_973431.2| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926218|ref|XP_008194833.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926220|ref|XP_008194834.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|642926222|ref|XP_008194835.1| PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum] 749752848 XM_011140486.1 61 2.74328e-21 PREDICTED: Harpegnathos saltator putative fatty acyl-CoA reductase CG5065 (LOC105182795), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 209 8.0e-16 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01715//PF01118//PF01073//PF01370 IPP transferase//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0006694//GO:0055114//GO:0008209//GO:0008033//GO:0008207//GO:0008210 steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//tRNA processing//C21-steroid hormone metabolic process//estrogen metabolic process GO:0016620//GO:0051287//GO:0016616//GO:0003854//GO:0050662//GO:0003824 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.51302 BF_2 20.24 0.38 2543 260810939 XP_002600180.1 645 2.7e-64 hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae]>gi|229285466|gb|EEN56192.1| hypothetical protein BRAFLDRAFT_66688 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NN14 482 8.7e-47 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF07776//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.51305 BF_2 107.00 2.95 1805 546678228 ERL88904.1 1130 1.1e-120 hypothetical protein D910_06285, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5VT52 251 3.8e-20 Regulation of nuclear pre-mRNA domain-containing protein 2 OS=Homo sapiens GN=RPRD2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2669 Regulator of nuclear mRNA Cluster-8309.51309 BF_2 41.00 2.43 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00964 Elicitin GO:0006952//GO:0009405 defense response//pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.51310 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF00935 Zinc finger, C2H2 type//Ribosomal protein L44 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0046872 structural constituent of ribosome//metal ion binding GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.51311 BF_2 20.89 3.67 525 478257445 ENN77601.1 432 2.8e-40 hypothetical protein YQE_05896, partial [Dendroctonus ponderosae] 159484014 XM_001700004.1 35 7.87111e-07 Chlamydomonas reinhardtii strain CC-503 cw92 mt+ K18164 NDUFAF7 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18164 Q2KHV5 305 6.0e-27 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 OS=Bos taurus GN=NDUFAF7 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2901 Uncharacterized conserved protein Cluster-8309.51313 BF_2 74.43 0.37 8702 642937185 XP_008198729.1 2663 9.1e-298 PREDICTED: ras opposite isoform X1 [Tribolium castaneum] 7321217 Y12732.2 115 4.68338e-50 Loligo pealei mRNA for sec1-like protein K15292 STXBP1, MUNC18-1 syntaxin-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15292 Q07327 2237 9.4e-250 Protein ROP OS=Drosophila melanogaster GN=Rop PE=2 SV=2 PF00023//PF00995//PF00856//PF05192//PF13606//PF02068//PF05033//PF11744 Ankyrin repeat//Sec1 family//SET domain//MutS domain III//Ankyrin repeat//Plant PEC family metallothionein//Pre-SET motif//Aluminium activated malate transporter GO:0006904//GO:0015743//GO:0016192//GO:0034968//GO:0006298//GO:0006554//GO:0006479 vesicle docking involved in exocytosis//malate transport//vesicle-mediated transport//histone lysine methylation//mismatch repair//lysine catabolic process//protein methylation GO:0005515//GO:0005524//GO:0018024//GO:0008270//GO:0030983 protein binding//ATP binding//histone-lysine N-methyltransferase activity//zinc ion binding//mismatched DNA binding GO:0005634 nucleus KOG1300 Vesicle trafficking protein Sec1 Cluster-8309.51315 BF_2 310.59 2.56 5368 642940052 XP_008200969.1 2894 0.0e+00 PREDICTED: ATPase family AAA domain-containing protein 2-like isoform X1 [Tribolium castaneum]>gi|270015968|gb|EFA12416.1| hypothetical protein TcasGA2_TC004983 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CDM1 1586 1.8e-174 ATPase family AAA domain-containing protein 2 OS=Mus musculus GN=Atad2 PE=1 SV=1 PF00910//PF04851//PF00005//PF07724//PF00439//PF00004//PF06068//PF05496//PF07728//PF01695 RNA helicase//Type III restriction enzyme, res subunit//ABC transporter//AAA domain (Cdc48 subfamily)//Bromodomain//ATPase family associated with various cellular activities (AAA)//TIP49 C-terminus//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein GO:0006310//GO:0006281 DNA recombination//DNA repair GO:0003724//GO:0009378//GO:0016887//GO:0005515//GO:0003723//GO:0003678//GO:0005524//GO:0016787//GO:0003677 RNA helicase activity//four-way junction helicase activity//ATPase activity//protein binding//RNA binding//DNA helicase activity//ATP binding//hydrolase activity//DNA binding GO:0009379//GO:0005657 Holliday junction helicase complex//replication fork KOG0732 AAA+-type ATPase containing the bromodomain Cluster-8309.51318 BF_2 46.60 0.35 5790 91083069 XP_967587.1 4327 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDW6 2521 7.3e-283 Dystrophin, isoforms A/C/F/G/H OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF01166//PF14641//PF08115//PF00569//PF16473//PF00435//PF00397//PF07649 TSC-22/dip/bun family//Helix-turn-helix DNA-binding domain of SPT6//SFI toxin family//Zinc finger, ZZ type//Domain of unknown function (DUF5051)//Spectrin repeat//WW domain//C1-like domain GO:0009405//GO:0055114//GO:0006355 pathogenesis//oxidation-reduction process//regulation of transcription, DNA-templated GO:0005515//GO:0003677//GO:0003700//GO:0047134//GO:0008270//GO:0005509//GO:0003676 protein binding//DNA binding//transcription factor activity, sequence-specific DNA binding//protein-disulfide reductase activity//zinc ion binding//calcium ion binding//nucleic acid binding GO:0005667//GO:0005576 transcription factor complex//extracellular region -- -- Cluster-8309.51321 BF_2 319.09 2.33 6021 91083069 XP_967587.1 4327 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VDW6 2521 7.6e-283 Dystrophin, isoforms A/C/F/G/H OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF14641//PF00569//PF08115//PF07649//PF00397//PF16473//PF00435//PF01166 Helix-turn-helix DNA-binding domain of SPT6//Zinc finger, ZZ type//SFI toxin family//C1-like domain//WW domain//Domain of unknown function (DUF5051)//Spectrin repeat//TSC-22/dip/bun family GO:0009405//GO:0006355//GO:0055114 pathogenesis//regulation of transcription, DNA-templated//oxidation-reduction process GO:0003677//GO:0005515//GO:0008270//GO:0005509//GO:0003676//GO:0003700//GO:0047134 DNA binding//protein binding//zinc ion binding//calcium ion binding//nucleic acid binding//transcription factor activity, sequence-specific DNA binding//protein-disulfide reductase activity GO:0005667//GO:0005576 transcription factor complex//extracellular region -- -- Cluster-8309.51328 BF_2 835.85 13.99 2787 642916479 XP_008191061.1 1715 2.5e-188 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5TUF1 1179 1.4e-127 Serrate RNA effector molecule homolog OS=Anopheles gambiae GN=Ars2 PE=3 SV=3 PF05793//PF09726//PF00076 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha)//Transmembrane protein//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006367//GO:0032968 transcription initiation from RNA polymerase II promoter//positive regulation of transcription elongation from RNA polymerase II promoter GO:0000166//GO:0003677//GO:0003676 nucleotide binding//DNA binding//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG2295 C2H2 Zn-finger protein Cluster-8309.51331 BF_2 1.00 3.05 269 332019131 EGI59647.1 249 2.3e-19 FLJ37770-like protein, partial [Acromyrmex echinatior] 746870179 XM_011067966.1 123 4.56113e-56 PREDICTED: Acromyrmex echinatior putative uncharacterized protein FLJ37770 (LOC105153239), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51332 BF_2 10.00 0.31 1655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51334 BF_2 35.00 1.54 1235 553041307 AGY54953.1 168 2.7e-09 encapsulation-relating protein [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51338 BF_2 151.86 2.04 3407 642936222 XP_008198354.1 1073 8.4e-114 PREDICTED: glutamyl aminopeptidase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32LQ0 675 4.9e-69 Glutamyl aminopeptidase OS=Bos taurus GN=ENPEP PE=2 SV=1 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.51339 BF_2 76.83 3.22 1286 91090842 XP_972243.1 960 4.0e-101 PREDICTED: large neutral amino acids transporter small subunit 1 [Tribolium castaneum]>gi|270013246|gb|EFA09694.1| hypothetical protein TcasGA2_TC011826 [Tribolium castaneum] 642935933 XM_967150.2 311 7.49067e-160 PREDICTED: Tribolium castaneum large neutral amino acids transporter small subunit 1 (LOC660956), mRNA K03450 SLC7A solute carrier family 7 (L-type amino acid transporter), other http://www.genome.jp/dbget-bin/www_bget?ko:K03450 Q8BGK6 605 2.4e-61 Y+L amino acid transporter 2 OS=Mus musculus GN=Slc7a6 PE=1 SV=1 PF00324//PF01384//PF13520 Amino acid permease//Phosphate transporter family//Amino acid permease GO:0003333//GO:0006810//GO:0006817//GO:0006865//GO:0055085 amino acid transmembrane transport//transport//phosphate ion transport//amino acid transport//transmembrane transport GO:0005315//GO:0015171 inorganic phosphate transmembrane transporter activity//amino acid transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1287 Amino acid transporters Cluster-8309.51340 BF_2 27.00 0.65 2033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51342 BF_2 298.00 5.53 2543 91090232 XP_968695.1 3206 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 51 homolog [Tribolium castaneum]>gi|270013774|gb|EFA10222.1| hypothetical protein TcasGA2_TC012418 [Tribolium castaneum] 462282022 APGK01057453.1 216 9.70063e-107 Dendroctonus ponderosae Seq01057463, whole genome shotgun sequence -- -- -- -- Q8MSY4 1960 3.6e-218 Vacuolar protein sorting-associated protein 51 homolog OS=Drosophila melanogaster GN=CG15087 PE=2 SV=1 PF06009//PF04048//PF04124//PF04513 Laminin Domain II//Sec8 exocyst complex component specific domain//Dor1-like family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0006904//GO:0007155//GO:0015031 vesicle docking involved in exocytosis//cell adhesion//protein transport GO:0005198 structural molecule activity GO:0019028//GO:0019031//GO:0017119//GO:0000145 viral capsid//viral envelope//Golgi transport complex//exocyst KOG2346 Uncharacterized conserved protein Cluster-8309.51343 BF_2 639.26 5.04 5589 478254436 ENN74688.1 2918 0.0e+00 hypothetical protein YQE_08805, partial [Dendroctonus ponderosae] 697484427 XM_009675369.1 47 1.89866e-12 PREDICTED: Struthio camelus australis methionyl-tRNA synthetase (MARS), partial mRNA K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q6PF21 2080 9.7e-232 Methionine--tRNA ligase, cytoplasmic OS=Xenopus laevis GN=mars PE=2 SV=1 PF00133//PF09334//PF08264//PF00458 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//Anticodon-binding domain of tRNA//WHEP-TRS domain GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity -- -- KOG1247 Methionyl-tRNA synthetase Cluster-8309.51346 BF_2 52.48 0.36 6323 642914898 XP_008190435.1 7116 0.0e+00 PREDICTED: cadherin-87A [Tribolium castaneum]>gi|642914900|ref|XP_008190436.1| PREDICTED: cadherin-87A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGG5 2918 0.0e+00 Cadherin-87A OS=Drosophila melanogaster GN=Cad87A PE=1 SV=4 PF00028 Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509 calcium ion binding GO:0016020 membrane -- -- Cluster-8309.51348 BF_2 65.68 0.83 3608 91077430 XP_966364.1 2481 4.8e-277 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [Tribolium castaneum]>gi|270001627|gb|EEZ98074.1| hypothetical protein TcasGA2_TC000481 [Tribolium castaneum] 752892703 XM_011266149.1 450 0 PREDICTED: Camponotus floridanus putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 (LOC105256330), mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 O35286 2035 1.0e-226 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Mus musculus GN=Dhx15 PE=1 SV=2 PF07652//PF00270//PF00005//PF04851//PF09339//PF00437//PF00448//PF01695//PF00063//PF04408 Flavivirus DEAD domain//DEAD/DEAH box helicase//ABC transporter//Type III restriction enzyme, res subunit//IclR helix-turn-helix domain//Type II/IV secretion system protein//SRP54-type protein, GTPase domain//IstB-like ATP binding protein//Myosin head (motor domain)//Helicase associated domain (HA2) GO:0006614//GO:0019079//GO:0006810//GO:0006355 SRP-dependent cotranslational protein targeting to membrane//viral genome replication//transport//regulation of transcription, DNA-templated GO:0004386//GO:0005524//GO:0016787//GO:0003677//GO:0008026//GO:0005525//GO:0003774//GO:0016887//GO:0003676 helicase activity//ATP binding//hydrolase activity//DNA binding//ATP-dependent helicase activity//GTP binding//motor activity//ATPase activity//nucleic acid binding GO:0016459 myosin complex KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.51349 BF_2 472.15 8.64 2572 91077430 XP_966364.1 3508 0.0e+00 PREDICTED: putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 [Tribolium castaneum]>gi|270001627|gb|EEZ98074.1| hypothetical protein TcasGA2_TC000481 [Tribolium castaneum] 665808807 XM_008554521.1 649 0 PREDICTED: Microplitis demolitor putative pre-mRNA-splicing factor ATP-dependent RNA helicase PRP1 (LOC103574950), transcript variant X2, mRNA K12820 DHX15, PRP43 pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15/PRP43 http://www.genome.jp/dbget-bin/www_bget?ko:K12820 O43143 2950 0.0e+00 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 OS=Homo sapiens GN=DHX15 PE=1 SV=2 PF07652//PF00270//PF04851//PF09339//PF00005//PF00448//PF00437//PF00063//PF04408//PF01695 Flavivirus DEAD domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//IclR helix-turn-helix domain//ABC transporter//SRP54-type protein, GTPase domain//Type II/IV secretion system protein//Myosin head (motor domain)//Helicase associated domain (HA2)//IstB-like ATP binding protein GO:0006355//GO:0006810//GO:0006614//GO:0019079 regulation of transcription, DNA-templated//transport//SRP-dependent cotranslational protein targeting to membrane//viral genome replication GO:0003676//GO:0016887//GO:0003774//GO:0005525//GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0004386 nucleic acid binding//ATPase activity//motor activity//GTP binding//ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//helicase activity GO:0016459 myosin complex KOG0925 mRNA splicing factor ATP-dependent RNA helicase Cluster-8309.5135 BF_2 3.00 0.54 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51350 BF_2 272.77 1.61 7362 642924922 XP_008194098.1 1584 1.0e-172 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMF0 206 2.6e-14 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 PF02196//PF01349//PF02205 Raf-like Ras-binding domain//Flavivirus non-structural protein NS4B//WH2 motif GO:0007165//GO:0006144//GO:0006370//GO:0009451//GO:0006396 signal transduction//purine nucleobase metabolic process//7-methylguanosine mRNA capping//RNA modification//RNA processing GO:0005057//GO:0004482//GO:0003779//GO:0003968//GO:0070008//GO:0004252//GO:0016817//GO:0017111//GO:0004483 receptor signaling protein activity//mRNA (guanine-N7-)-methyltransferase activity//actin binding//RNA-directed RNA polymerase activity//serine-type exopeptidase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//nucleoside-triphosphatase activity//mRNA (nucleoside-2'-O-)-methyltransferase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.51354 BF_2 8.00 0.46 1015 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51355 BF_2 35.99 0.82 2119 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04441 Poxvirus early transcription factor (VETF), large subunit GO:0045893 positive regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.51358 BF_2 81.00 0.49 7197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51359 BF_2 687.35 6.35 4813 478251301 ENN71769.1 1449 3.0e-157 hypothetical protein YQE_11504, partial [Dendroctonus ponderosae] 820835140 XM_012484551.1 290 1.34933e-147 PREDICTED: Apis florea putative GPI-anchor transamidase (LOC105735008), mRNA K05290 PIGK phosphatidylinositol glycan, class K http://www.genome.jp/dbget-bin/www_bget?ko:K05290 Q8T4E1 1232 1.8e-133 Putative GPI-anchor transamidase OS=Drosophila melanogaster GN=CG4406 PE=2 SV=1 PF01650//PF01979 Peptidase C13 family//Amidohydrolase family GO:0006508 proteolysis GO:0016787//GO:0008233 hydrolase activity//peptidase activity -- -- KOG1349 Gpi-anchor transamidase Cluster-8309.51360 BF_2 4.00 0.31 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51361 BF_2 153.51 4.24 1800 91084337 XP_972793.1 775 1.6e-79 PREDICTED: cysteine string protein [Tribolium castaneum]>gi|270008724|gb|EFA05172.1| hypothetical protein TcasGA2_TC015301 [Tribolium castaneum] 332372481 BT126419.1 150 3.33745e-70 Dendroctonus ponderosae clone DPO045_E11 unknown mRNA K09525 DNAJC5 DnaJ homolog subfamily C member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09525 Q03751 515 9.2e-51 DnaJ homolog subfamily C member 5 homolog OS=Drosophila melanogaster GN=Csp PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0716 Molecular chaperone (DnaJ superfamily) Cluster-8309.51362 BF_2 167.65 10.30 968 817218269 XP_012284990.1 863 5.3e-90 PREDICTED: ATP-dependent Clp protease proteolytic subunit, mitochondrial [Orussus abietinus] -- -- -- -- -- K01358 clpP, CLPP ATP-dependent Clp protease, protease subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01358 Q16740 781 7.1e-82 ATP-dependent Clp protease proteolytic subunit, mitochondrial OS=Homo sapiens GN=CLPP PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0840 ATP-dependent Clp protease, proteolytic subunit Cluster-8309.51363 BF_2 849.80 6.74 5563 91093076 XP_968784.1 1144 8.0e-122 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 1007 2.5e-107 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51366 BF_2 1.70 0.39 467 91093076 XP_968784.1 693 1.3e-70 PREDICTED: elongation of very long chain fatty acids protein AAEL008004 [Tribolium castaneum]>gi|270013035|gb|EFA09483.1| hypothetical protein TcasGA2_TC010977 [Tribolium castaneum] -- -- -- -- -- K10250 ELOVL7 elongation of very long chain fatty acids protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10250 Q1HRV8 584 2.4e-59 Elongation of very long chain fatty acids protein AAEL008004 OS=Aedes aegypti GN=AAEL008004 PE=2 SV=2 PF01151 GNS1/SUR4 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51367 BF_2 149.84 1.72 3922 642922996 XP_008200488.1 1531 7.5e-167 PREDICTED: GATA-binding factor A isoform X2 [Tribolium castaneum] 687916009 LK995611.1 47 1.32868e-12 Rhabditophanes sp. KR3021 genome assembly Rhabditophanes_sp_KR3021 ,scaffold RSKR_scaffold0000049 K09183 GATA4 GATA-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09183 P52168 796 5.2e-83 GATA-binding factor A OS=Drosophila melanogaster GN=pnr PE=1 SV=1 PF01873//PF08273//PF00320 Domain found in IF2B/IF5//Zinc-binding domain of primase-helicase//GATA zinc finger GO:0006355//GO:0006413//GO:0006269//GO:0006351//GO:0006446 regulation of transcription, DNA-templated//translational initiation//DNA replication, synthesis of RNA primer//transcription, DNA-templated//regulation of translational initiation GO:0043565//GO:0008270//GO:0003700//GO:0004386//GO:0003896//GO:0003743 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding//helicase activity//DNA primase activity//translation initiation factor activity GO:0005840//GO:0005730//GO:0005657//GO:0005667 ribosome//nucleolus//replication fork//transcription factor complex KOG1601 GATA-4/5/6 transcription factors Cluster-8309.51368 BF_2 126.33 1.32 4276 642914414 XP_008201486.1 3260 0.0e+00 PREDICTED: protein groucho-1-like isoform X2 [Tribolium castaneum] 642914413 XM_008203264.1 710 0 PREDICTED: Tribolium castaneum protein groucho-1-like (LOC655664), transcript variant X2, mRNA -- -- -- -- Q62441 2314 5.4e-259 Transducin-like enhancer protein 4 OS=Mus musculus GN=Tle4 PE=1 SV=4 PF03920//PF02183//PF00400 Groucho/TLE N-terminal Q-rich domain//Homeobox associated leucine zipper//WD domain, G-beta repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.51369 BF_2 385.48 3.40 5034 642914414 XP_008201486.1 3275 0.0e+00 PREDICTED: protein groucho-1-like isoform X2 [Tribolium castaneum] 642914413 XM_008203264.1 911 0 PREDICTED: Tribolium castaneum protein groucho-1-like (LOC655664), transcript variant X2, mRNA -- -- -- -- Q62441 2324 4.4e-260 Transducin-like enhancer protein 4 OS=Mus musculus GN=Tle4 PE=1 SV=4 PF00400//PF10538//PF03920//PF02183 WD domain, G-beta repeat//Immunoreceptor tyrosine-based activation motif//Groucho/TLE N-terminal Q-rich domain//Homeobox associated leucine zipper GO:0007165//GO:0006355 signal transduction//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0043565 protein binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.51374 BF_2 219.89 3.46 2949 512892422 XP_004922927.1 720 6.2e-73 PREDICTED: uncharacterized protein LOC101739908 [Bombyx mori] -- -- -- -- -- K19410 LEMD3 inner nuclear membrane protein Man1 http://www.genome.jp/dbget-bin/www_bget?ko:K19410 Q9WU40 209 4.6e-15 Inner nuclear membrane protein Man1 OS=Mus musculus GN=Lemd3 PE=1 SV=2 PF09402 Man1-Src1p-C-terminal domain -- -- -- -- GO:0005639 integral component of nuclear inner membrane -- -- Cluster-8309.51375 BF_2 166.24 3.56 2238 380017601 XP_003692741.1 1817 2.9e-200 PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X2 [Apis florea] -- -- -- -- -- -- -- -- -- Q6GN91 1104 5.8e-119 5'-nucleotidase domain-containing protein 3 OS=Xenopus laevis GN=nt5dc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.51376 BF_2 28.71 0.50 2672 808131500 XP_012168405.1 1394 3.9e-151 PREDICTED: 5'-nucleotidase domain-containing protein 3 isoform X1 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q6GN91 848 3.3e-89 5'-nucleotidase domain-containing protein 3 OS=Xenopus laevis GN=nt5dc3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2469 IMP-GMP specific 5'-nucleotidase Cluster-8309.51377 BF_2 17.00 2.06 633 478262482 ENN81153.1 304 2.3e-25 hypothetical protein YQE_02519, partial [Dendroctonus ponderosae]>gi|546672793|gb|ERL84549.1| hypothetical protein D910_01979 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51380 BF_2 3.00 0.47 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51381 BF_2 107.00 1.88 2662 270016078 EFA12526.1 192 9.4e-12 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02160 Cauliflower mosaic virus peptidase (A3) GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.51382 BF_2 2.00 1.19 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51384 BF_2 7.00 3.66 364 478251443 ENN71908.1 168 7.7e-10 hypothetical protein YQE_11445, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T079 139 7.3e-08 Putative oxidoreductase GLYR1 homolog OS=Drosophila melanogaster GN=CG4747 PE=1 SV=1 PF04926//PF14833 Poly(A) polymerase predicted RNA binding domain//NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase GO:0043631 RNA polyadenylation GO:0003723//GO:0051287 RNA binding//NAD binding -- -- -- -- Cluster-8309.51387 BF_2 28.89 0.93 1585 91079184 XP_968431.1 1840 4.5e-203 PREDICTED: histone acetyltransferase KAT8 [Tribolium castaneum]>gi|270004246|gb|EFA00694.1| hypothetical protein TcasGA2_TC003573 [Tribolium castaneum] 755929079 XM_011311259.1 304 7.2256e-156 PREDICTED: Fopius arisanus histone acetyltransferase KAT8 (LOC105270370), mRNA K11308 MYST1, MOF, KAT8 histone acetyltransferase MYST1 http://www.genome.jp/dbget-bin/www_bget?ko:K11308 Q5XI06 1508 5.8e-166 Histone acetyltransferase KAT8 OS=Rattus norvegicus GN=Kat8 PE=2 SV=1 PF00583//PF13508//PF01853//PF16719//PF14532 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//MOZ/SAS family//SAWADEE domain//Sigma-54 interaction domain GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0016747//GO:0003682//GO:0008134//GO:0008080//GO:0005524 transferase activity, transferring acyl groups other than amino-acyl groups//chromatin binding//transcription factor binding//N-acetyltransferase activity//ATP binding GO:0005667//GO:0005634//GO:0000785 transcription factor complex//nucleus//chromatin KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.51389 BF_2 265.34 5.45 2322 91087367 XP_975633.1 890 9.5e-93 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 343 1.0e-30 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51390 BF_2 110.27 2.21 2378 91087367 XP_975633.1 855 1.1e-88 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XJA3 317 1.1e-27 Protein PRRC1 OS=Danio rerio GN=prrc1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51393 BF_2 34.35 0.83 2009 642927937 XP_008195453.1 1603 1.7e-175 PREDICTED: pregnancy zone protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63041 398 3.8e-37 Alpha-1-macroglobulin OS=Rattus norvegicus GN=A1m PE=1 SV=1 PF00207 Alpha-2-macroglobulin family -- -- GO:0004866 endopeptidase inhibitor activity -- -- -- -- Cluster-8309.51397 BF_2 192.86 21.58 661 270010984 EFA07432.1 185 1.5e-11 mutagen-sensitive 312 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05735 Thrombospondin C-terminal region GO:0007155 cell adhesion GO:0005509 calcium ion binding GO:0005576 extracellular region -- -- Cluster-8309.51401 BF_2 480.12 10.09 2277 156564355 NP_001096056.1 2228 6.6e-248 aromatic-L-amino-acid decarboxylase [Tribolium castaneum]>gi|155675828|gb|ABU25222.1| dopa decarboxylase [Tribolium castaneum] 332373577 BT126968.1 370 0 Dendroctonus ponderosae clone DPO1325_L24 unknown mRNA K01593 DDC aromatic-L-amino-acid decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01593 P05031 1950 4.7e-217 Aromatic-L-amino-acid decarboxylase OS=Drosophila melanogaster GN=Ddc PE=1 SV=4 PF00282//PF01212//PF00155//PF05889 Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase//Aminotransferase class I and II//O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GO:0042432//GO:0006570//GO:0019752//GO:0009821//GO:0009058//GO:0006520//GO:0006558//GO:0006568//GO:0006547 indole biosynthetic process//tyrosine metabolic process//carboxylic acid metabolic process//alkaloid biosynthetic process//biosynthetic process//cellular amino acid metabolic process//L-phenylalanine metabolic process//tryptophan metabolic process//histidine metabolic process GO:0030170//GO:0016831//GO:0016740//GO:0004058//GO:0016829 pyridoxal phosphate binding//carboxy-lyase activity//transferase activity//aromatic-L-amino-acid decarboxylase activity//lyase activity -- -- KOG0628 Aromatic-L-amino-acid/L-histidine decarboxylase Cluster-8309.51404 BF_2 29.00 0.78 1850 91087279 XP_975547.1 975 1.1e-102 PREDICTED: DNA repair protein complementing XP-C cells homolog [Tribolium castaneum]>gi|270009546|gb|EFA05994.1| hypothetical protein TcasGA2_TC008820 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24595 304 2.8e-26 DNA repair protein complementing XP-C cells homolog OS=Drosophila melanogaster GN=mus210 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51408 BF_2 2.00 6.46 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02689 Helicase -- -- GO:0004386//GO:0005524 helicase activity//ATP binding -- -- -- -- Cluster-8309.51411 BF_2 885.31 10.79 3721 91093829 XP_969227.1 1839 1.4e-202 PREDICTED: transmembrane protein 161B [Tribolium castaneum] -- -- -- -- -- K08963 mtnA methylthioribose-1-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K08963 B4NG41 1425 5.7e-156 Methylthioribose-1-phosphate isomerase OS=Drosophila willistoni GN=GK22419 PE=3 SV=1 PF01008//PF04632//PF10018//PF00336 Initiation factor 2 subunit family//Fusaric acid resistance protein family//Vitamin-D-receptor interacting Mediator subunit 4//DNA polymerase (viral) C-terminal domain GO:0006357//GO:0051252//GO:0006810//GO:0044237 regulation of transcription from RNA polymerase II promoter//regulation of RNA metabolic process//transport//cellular metabolic process GO:0004523//GO:0001104 RNA-DNA hybrid ribonuclease activity//RNA polymerase II transcription cofactor activity GO:0005886//GO:0016592 plasma membrane//mediator complex KOG1468 Predicted translation initiation factor related to eIF-2B alpha/beta/delta subunits (CIG2/IDI2) Cluster-8309.51414 BF_2 386.45 4.06 4265 808140666 XP_012171915.1 1927 9.9e-213 PREDICTED: transcriptional regulator ATRX homolog [Bombus terrestris] 642928856 XM_008197369.1 131 2.91618e-59 PREDICTED: Tribolium castaneum transcriptional regulator ATRX homolog (LOC657738), transcript variant X2, mRNA K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 Q9GQN5 1100 3.2e-118 Transcriptional regulator ATRX homolog OS=Drosophila melanogaster GN=XNP PE=1 SV=2 PF08361//PF04851//PF00176 MAATS-type transcriptional repressor, C-terminal region//Type III restriction enzyme, res subunit//SNF2 family N-terminal domain -- -- GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.51416 BF_2 262.59 8.90 1521 642917952 XP_008198956.1 1283 1.7e-138 PREDICTED: proton-coupled amino acid transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K14209 SLC36A, PAT solute carrier family 36 (proton-coupled amino acid transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K14209 Q8CH36 499 5.6e-49 Proton-coupled amino acid transporter 4 OS=Mus musculus GN=Slc36a4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1304 Amino acid transporters Cluster-8309.51418 BF_2 39.81 0.38 4643 195431192 XP_002063632.1 2154 5.1e-239 GK22019 [Drosophila willistoni]>gi|194159717|gb|EDW74618.1| GK22019 [Drosophila willistoni] 167466191 NM_001114369.1 314 5.92727e-161 Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), mRNA -- -- -- -- Q9VS29 871 1.2e-91 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF04110//PF05790//PF13895//PF16990 Ubiquitin-like autophagy protein Apg12//Immunoglobulin C2-set domain//Immunoglobulin domain//Carbohydrate binding module (family 35) GO:0000045//GO:0007155 autophagosome assembly//cell adhesion GO:0005515//GO:0030246 protein binding//carbohydrate binding GO:0005737//GO:0016021 cytoplasm//integral component of membrane -- -- Cluster-8309.51420 BF_2 37.09 1.02 1804 260799997 XP_002594923.1 439 1.5e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- P17010 323 1.7e-28 Zinc finger X-chromosomal protein OS=Homo sapiens GN=ZFX PE=2 SV=2 PF02150//PF13465//PF00096//PF07649 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872//GO:0047134 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//protein-disulfide reductase activity GO:0005730 nucleolus -- -- Cluster-8309.51421 BF_2 136.33 6.34 1186 270007922 EFA04370.1 1444 2.8e-157 hypothetical protein TcasGA2_TC014668 [Tribolium castaneum] -- -- -- -- -- K07200 PRKAG 5'-AMP-activated protein kinase, regulatory gamma subunit http://www.genome.jp/dbget-bin/www_bget?ko:K07200 P54619 970 1.1e-103 5'-AMP-activated protein kinase subunit gamma-1 OS=Homo sapiens GN=PRKAG1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1764 5'-AMP-activated protein kinase, gamma subunit Cluster-8309.51422 BF_2 15.35 0.34 2162 820843158 XP_012339808.1 958 1.2e-100 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 isoform X1 [Apis florea] 642930305 XM_008198117.1 353 0 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04955 HCN2 hyperpolarization activated cyclic nucleotide-gated potassium channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04955 Q9UL51 617 1.6e-62 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 OS=Homo sapiens GN=HCN2 PE=1 SV=3 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.51423 BF_2 138.49 7.79 1031 478252870 ENN73259.1 802 6.7e-83 hypothetical protein YQE_10155, partial [Dendroctonus ponderosae]>gi|546674747|gb|ERL86052.1| hypothetical protein D910_03466 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U145 311 2.4e-27 Transmembrane protein 64 OS=Mus musculus GN=Tmem64 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51425 BF_2 128.51 1.42 4086 642914138 XP_008201561.1 270 1.3e-20 PREDICTED: uncharacterized protein LOC103315216 isoform X1 [Tribolium castaneum]>gi|270001587|gb|EEZ98034.1| hypothetical protein TcasGA2_TC000435 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.51428 BF_2 75.13 0.92 3704 270012487 EFA08935.1 2481 4.9e-277 hypothetical protein TcasGA2_TC006642 [Tribolium castaneum] 645037466 XM_008219044.1 217 3.94338e-107 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1544 9.1e-170 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF02214//PF00520 BTB/POZ domain//Ion transport protein GO:0055085//GO:0006811//GO:0051260 transmembrane transport//ion transport//protein homooligomerization GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.5143 BF_2 9.19 0.79 775 642931265 XP_008196504.1 614 3.2e-61 PREDICTED: high mobility group B protein 13-like [Tribolium castaneum]>gi|270012132|gb|EFA08580.1| hypothetical protein TcasGA2_TC006235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03435 125 6.6e-06 Non-histone protein 10 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NHP10 PE=1 SV=1 PF00340 Interleukin-1 / 18 -- -- -- -- GO:0005615 extracellular space KOG0381 HMG box-containing protein Cluster-8309.51430 BF_2 40.30 0.73 2598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51435 BF_2 416.00 9.43 2132 332375180 AEE62731.1 1124 6.4e-120 unknown [Dendroctonus ponderosae] 195134259 XM_002011519.1 83 6.9721e-33 Drosophila mojavensis GI11033 (Dmoj\GI11033), mRNA -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.51438 BF_2 71.24 1.27 2636 766932595 XP_011498525.1 498 3.1e-47 PREDICTED: lipase 3-like [Ceratosolen solmsi marchali] -- -- -- -- -- -- -- -- -- O46108 426 2.8e-40 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083//PF02450//PF06821 Partial alpha/beta-hydrolase lipase region//Lecithin:cholesterol acyltransferase//Serine hydrolase GO:0042967//GO:0006629 acyl-carrier-protein biosynthetic process//lipid metabolic process GO:0008374//GO:0016787 O-acyltransferase activity//hydrolase activity -- -- -- -- Cluster-8309.51441 BF_2 138.62 3.25 2074 642926820 XP_008195027.1 1979 4.5e-219 PREDICTED: uncharacterized protein LOC100142170 isoform X2 [Tribolium castaneum]>gi|270008388|gb|EFA04836.1| hypothetical protein TcasGA2_TC014886 [Tribolium castaneum] 642926819 XM_008196805.1 319 4.36019e-164 PREDICTED: Tribolium castaneum uncharacterized LOC100142170 (LOC100142170), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF17096//PF14719 Altered inheritance of mitochondria protein 3//Phosphotyrosine interaction domain (PTB/PID) GO:0051016 barbed-end actin filament capping GO:0005515 protein binding GO:0030479 actin cortical patch -- -- Cluster-8309.51443 BF_2 15.86 0.44 1785 817011233 AKF11870.1 504 4.2e-48 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K01253 EPHX1 microsomal epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01253 Q8MZR6 416 2.8e-39 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.51445 BF_2 27.00 0.40 3135 270003145 EEZ99592.1 4002 0.0e+00 hypothetical protein TcasGA2_TC001579 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16832 740 1.3e-76 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF04579//PF00069//PF07714 Keratin, high-sulphur matrix protein//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005198//GO:0005524 protein kinase activity//structural molecule activity//ATP binding GO:0045095 keratin filament KOG1094 Discoidin domain receptor DDR1 Cluster-8309.51446 BF_2 322.44 4.43 3332 478250819 ENN71311.1 810 2.6e-83 hypothetical protein YQE_12236, partial [Dendroctonus ponderosae]>gi|546679724|gb|ERL90139.1| hypothetical protein D910_07493 [Dendroctonus ponderosae] -- -- -- -- -- K14775 UTP30, RSL1D1 ribosome biogenesis protein UTP30 http://www.genome.jp/dbget-bin/www_bget?ko:K14775 Q9VLK2 333 2.2e-29 Ribosomal L1 domain-containing protein CG13096 OS=Drosophila melanogaster GN=CG13096 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51450 BF_2 116.00 3.44 1699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51454 BF_2 97.04 0.57 7353 189234456 XP_968035.2 3830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 2.17074e-112 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 2695 6.2e-303 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF00454 Phosphatidylinositol 3- and 4-kinase GO:0036092//GO:0046854//GO:0048015 phosphatidylinositol-3-phosphate biosynthetic process//phosphatidylinositol phosphorylation//phosphatidylinositol-mediated signaling GO:0005524//GO:0016773//GO:0016303 ATP binding//phosphotransferase activity, alcohol group as acceptor//1-phosphatidylinositol-3-kinase activity -- -- KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.51455 BF_2 3.00 1.28 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51456 BF_2 180.41 6.41 1464 270015295 EFA11743.1 526 9.6e-51 hypothetical protein TcasGA2_TC004233 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51457 BF_2 381.25 7.39 2445 189234456 XP_968035.2 2646 2.4e-296 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 7.15523e-113 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 1885 1.7e-209 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF01481//PF00454 Arterivirus nucleocapsid protein//Phosphatidylinositol 3- and 4-kinase GO:0036092//GO:0048015//GO:0046854 phosphatidylinositol-3-phosphate biosynthetic process//phosphatidylinositol-mediated signaling//phosphatidylinositol phosphorylation GO:0016303//GO:0005524//GO:0016773 1-phosphatidylinositol-3-kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0019013 viral nucleocapsid KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.51460 BF_2 5.00 2.50 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51462 BF_2 13.39 0.46 1497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51469 BF_2 59.00 1.92 1571 795010007 XP_011864749.1 707 1.1e-71 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] 462367335 APGK01026939.1 59 1.1212e-19 Dendroctonus ponderosae Seq01026949, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF13404//PF00126 AsnC-type helix-turn-helix domain//Bacterial regulatory helix-turn-helix protein, lysR family GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.51471 BF_2 2.00 0.77 395 307184971 EFN71217.1 155 2.7e-08 hypothetical protein EAG_05969, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51475 BF_2 9.34 0.52 1043 768418838 XP_011550121.1 214 1.0e-14 PREDICTED: uncharacterized protein LOC105382004 [Plutella xylostella]>gi|768424236|ref|XP_011553062.1| PREDICTED: uncharacterized protein LOC105384507 [Plutella xylostella]>gi|768439288|ref|XP_011561267.1| PREDICTED: uncharacterized protein LOC105391485 [Plutella xylostella]>gi|768449353|ref|XP_011566757.1| PREDICTED: uncharacterized protein LOC105396454 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51477 BF_2 26.17 1.07 1308 768418838 XP_011550121.1 209 4.9e-14 PREDICTED: uncharacterized protein LOC105382004 [Plutella xylostella]>gi|768424236|ref|XP_011553062.1| PREDICTED: uncharacterized protein LOC105384507 [Plutella xylostella]>gi|768439288|ref|XP_011561267.1| PREDICTED: uncharacterized protein LOC105391485 [Plutella xylostella]>gi|768449353|ref|XP_011566757.1| PREDICTED: uncharacterized protein LOC105396454 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06017 Unconventional myosin tail, actin- and lipid-binding -- -- GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.51478 BF_2 17.04 0.95 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06017 Unconventional myosin tail, actin- and lipid-binding -- -- GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.51479 BF_2 39.42 1.35 1507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5148 BF_2 30.00 0.89 1696 642914136 XP_008201560.1 375 3.6e-33 PREDICTED: uncharacterized protein LOC103315215 [Tribolium castaneum]>gi|270002164|gb|EEZ98611.1| hypothetical protein TcasGA2_TC001133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51481 BF_2 4.00 2.19 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.51487 BF_2 33.97 0.88 1910 189235509 XP_969871.2 1682 1.1e-184 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 550 8.5e-55 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51489 BF_2 157.26 2.65 2774 270005301 EFA01749.1 1244 1.0e-133 hypothetical protein TcasGA2_TC007347 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.51495 BF_2 136.38 2.85 2288 642915507 XP_008190646.1 500 1.6e-47 PREDICTED: suppressor of cytokine signaling 6 [Tribolium castaneum]>gi|270004015|gb|EFA00463.1| hypothetical protein TcasGA2_TC003320 [Tribolium castaneum] -- -- -- -- -- K04699 SOCS6_7 suppressor of cytokine signaling 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04699 Q9JLY0 390 3.7e-36 Suppressor of cytokine signaling 6 OS=Mus musculus GN=Socs6 PE=1 SV=2 PF07525 SOCS box GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.5150 BF_2 6.00 0.67 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10541 Nuclear envelope localisation domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51501 BF_2 73.85 1.28 2693 91090484 XP_968697.1 513 5.7e-49 PREDICTED: DNA-directed RNA polymerase III subunit RPC4 [Tribolium castaneum]>gi|270013359|gb|EFA09807.1| hypothetical protein TcasGA2_TC011952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05423 164 6.9e-10 DNA-directed RNA polymerase III subunit RPC4 OS=Homo sapiens GN=POLR3D PE=1 SV=2 PF05132 RNA polymerase III RPC4 GO:0006206//GO:0006383//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005666 nucleolus//DNA-directed RNA polymerase III complex -- -- Cluster-8309.51502 BF_2 1208.08 10.53 5085 270016078 EFA12526.1 1340 1.4e-144 hypothetical protein TcasGA2_TC003738 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7LHG5 939 1.8e-99 Transposon Ty3-I Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-I PE=3 SV=2 PF02406//PF00665//PF03539 MmoB/DmpM family//Integrase core domain//Spumavirus aspartic protease (A9) GO:0015074//GO:0006725//GO:0006508 DNA integration//cellular aromatic compound metabolic process//proteolysis GO:0004497//GO:0004190 monooxygenase activity//aspartic-type endopeptidase activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.51506 BF_2 79.20 1.26 2923 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51511 BF_2 23.00 0.71 1649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51516 BF_2 140.38 1.15 5393 815769358 XP_012234792.1 1736 1.8e-190 PREDICTED: synaptotagmin-7 isoform X3 [Linepithema humile]>gi|815769360|ref|XP_012234793.1| PREDICTED: synaptotagmin-7 isoform X3 [Linepithema humile] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 1.9e-91 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168//PF04545 C2 domain//Sigma-70, region 4 GO:0006352//GO:0006355 DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0005515//GO:0003700//GO:0016987//GO:0003677 protein binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity//DNA binding GO:0005667 transcription factor complex KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.51517 BF_2 94.25 2.28 2014 307197059 EFN78431.1 161 2.8e-08 Transposable element Tc3 transposase, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51521 BF_2 376.26 13.80 1428 91076680 XP_971073.1 809 1.4e-83 PREDICTED: AP-1 complex subunit sigma-2 isoform X1 [Tribolium castaneum]>gi|270001880|gb|EEZ98327.1| hypothetical protein TcasGA2_TC000781 [Tribolium castaneum] 242011937 XM_002426655.1 178 7.1698e-86 Pediculus humanus corporis clathrin coat assembly protein ap19, putative, mRNA K12394 AP1S1_2 AP-1 complex subunit sigma 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K12394 P56377 680 5.4e-70 AP-1 complex subunit sigma-2 OS=Homo sapiens GN=AP1S2 PE=1 SV=1 -- -- GO:0006886//GO:0016192//GO:0015031 intracellular protein transport//vesicle-mediated transport//protein transport GO:0008565 protein transporter activity GO:0030117 membrane coat KOG0934 Clathrin adaptor complex, small subunit Cluster-8309.51525 BF_2 110.80 2.62 2057 270013936 EFA10384.1 1688 2.5e-185 hypothetical protein TcasGA2_TC012615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2RUV4 717 4.0e-74 Rho GTPase-activating protein 21 OS=Xenopus tropicalis GN=arhgap21 PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- KOG4407 Predicted Rho GTPase-activating protein Cluster-8309.51528 BF_2 501.97 8.34 2806 189233695 XP_001812208.1 496 5.6e-47 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 371 7.2e-34 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF00076//PF16367//PF08777 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//RNA binding motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.51530 BF_2 1.00 0.32 418 270013391 EFA09839.1 584 5.2e-58 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 694449459 XM_009352104.1 67 1.00427e-24 PREDICTED: Pyrus x bretschneideri uncharacterized LOC103941904 (LOC103941904), partial mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51531 BF_2 72.70 1.26 2708 91083763 XP_971910.1 849 6.3e-88 PREDICTED: transcription factor Sox-21-A [Tribolium castaneum]>gi|270008131|gb|EFA04579.1| Sox21a [Tribolium castaneum] 736152814 XM_010766176.1 130 6.62688e-59 PREDICTED: Notothenia coriiceps SRY (sex determining region Y)-box 2 (sox2), mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q2Z1R2 362 7.6e-33 Transcription factor Sox-1b OS=Danio rerio GN=sox1b PE=2 SV=1 PF12336 SOX transcription factor GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.51533 BF_2 464.00 8.82 2487 91082983 XP_974176.1 1153 3.2e-123 PREDICTED: tetratricopeptide repeat protein 19 homolog, mitochondrial [Tribolium castaneum]>gi|270007637|gb|EFA04085.1| hypothetical protein TcasGA2_TC014319 [Tribolium castaneum] -- -- -- -- -- K18169 TTC19 tetratricopeptide repeat protein 19, mitochondrial http://www.genome.jp/dbget-bin/www_bget?ko:K18169 Q8SYD0 577 8.2e-58 Tetratricopeptide repeat protein 19 homolog, mitochondrial OS=Drosophila melanogaster GN=Ttc19 PE=2 SV=1 PF08631//PF13374//PF00515//PF13181//PF13414//PF13176 Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat GO:0051321 meiotic cell cycle GO:0005515 protein binding -- -- KOG1840 Kinesin light chain Cluster-8309.51535 BF_2 26.28 0.78 1699 751227278 XP_011167114.1 293 1.2e-23 PREDICTED: uncharacterized protein LOC105200996 isoform X1 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.51538 BF_2 112.91 4.75 1282 332376577 AEE63428.1 860 1.6e-89 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01307 GGH gamma-glutamyl hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01307 A7YWG4 452 1.3e-43 Gamma-glutamyl hydrolase OS=Bos taurus GN=GGH PE=2 SV=1 PF07722 Peptidase C26 GO:0006541 glutamine metabolic process GO:0016787 hydrolase activity -- -- KOG1559 Gamma-glutamyl hydrolase Cluster-8309.51541 BF_2 389.83 2.90 5907 642938800 XP_008199891.1 1155 4.5e-123 PREDICTED: collagen alpha-1(V) chain-like [Tribolium castaneum] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 P20908 777 1.3e-80 Collagen alpha-1(V) chain OS=Homo sapiens GN=COL5A1 PE=1 SV=3 PF01410//PF02948 Fibrillar collagen C-terminal domain//Amelogenin GO:0007275 multicellular organismal development GO:0005201 extracellular matrix structural constituent GO:0005578//GO:0005581 proteinaceous extracellular matrix//collagen trimer -- -- Cluster-8309.51543 BF_2 192.17 1.49 5669 642938800 XP_008199891.1 1187 8.4e-127 PREDICTED: collagen alpha-1(V) chain-like [Tribolium castaneum] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 P20908 777 1.2e-80 Collagen alpha-1(V) chain OS=Homo sapiens GN=COL5A1 PE=1 SV=3 PF02948//PF01410 Amelogenin//Fibrillar collagen C-terminal domain GO:0007275 multicellular organismal development GO:0005201 extracellular matrix structural constituent GO:0005581//GO:0005578 collagen trimer//proteinaceous extracellular matrix -- -- Cluster-8309.51544 BF_2 23.00 0.64 1789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13174 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51547 BF_2 211.72 2.55 3764 91081013 XP_975219.1 1786 1.9e-196 PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920022|ref|XP_008192171.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|642920024|ref|XP_008192172.1| PREDICTED: ikaros family zinc finger protein [Tribolium castaneum]>gi|270005333|gb|EFA01781.1| hypothetical protein TcasGA2_TC007382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q07230 247 2.3e-19 Zinc finger and SCAN domain-containing protein 2 OS=Mus musculus GN=Zscan2 PE=1 SV=1 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.51555 BF_2 59.68 4.75 813 642931789 XP_008196729.1 275 6.8e-22 PREDICTED: chromatin accessibility complex protein 1 [Tribolium castaneum] -- -- -- -- -- K11656 CHRAC1, CHRAC15 chromatin accessibility complex protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11656 Q9NRG0 184 1.0e-12 Chromatin accessibility complex protein 1 OS=Homo sapiens GN=CHRAC1 PE=1 SV=1 PF00125 Core histone H2A/H2B/H3/H4 -- -- GO:0003677 DNA binding -- -- KOG1657 CCAAT-binding factor, subunit C (HAP5) Cluster-8309.51558 BF_2 40.79 0.50 3681 91094203 XP_971608.1 1093 4.3e-116 PREDICTED: dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase [Tribolium castaneum]>gi|270010912|gb|EFA07360.1| hypothetical protein TcasGA2_TC015960 [Tribolium castaneum] 826492697 XM_012684964.1 53 5.75751e-16 PREDICTED: Monomorium pharaonis probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (LOC105838989), mRNA K03847 ALG12 alpha-1,6-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03847 Q9VH78 740 1.5e-76 Probable Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase OS=Drosophila melanogaster GN=CG8412 PE=2 SV=1 PF03901 Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016757 transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG2516 Protein involved in dolichol pathway for N-glycosylation (mannosyltransferase family) Cluster-8309.51559 BF_2 19.81 1.72 769 646640094 KDQ71559.1 200 3.2e-13 hypothetical protein L798_09467 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5156 BF_2 5.86 0.33 1028 642915020 XP_008190486.1 245 2.6e-18 PREDICTED: uncharacterized protein LOC103312205 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51560 BF_2 181.63 3.75 2311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51561 BF_2 2.00 0.75 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51565 BF_2 189.14 2.99 2936 122114669 NP_001073624.1 3027 0.0e+00 Sip1/TFIP11 interacting protein [Tribolium castaneum]>gi|85363108|gb|ABC69932.1| STIP [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q9Y103 1539 2.7e-169 Septin-interacting protein 1 OS=Drosophila melanogaster GN=sip1 PE=1 SV=1 PF07842//PF01585 GC-rich sequence DNA-binding factor-like protein//G-patch domain GO:0008380//GO:0006355//GO:0006397 RNA splicing//regulation of transcription, DNA-templated//mRNA processing GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0005681//GO:0005634 spliceosomal complex//nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.51569 BF_2 11447.01 295.44 1908 264681482 NP_001161130.1 584 2.4e-57 uncharacterized protein LOC660544 precursor [Tribolium castaneum]>gi|262316919|emb|CBC01171.1| chymotrypsin-like proteinase 6A precursor [Tribolium castaneum]>gi|270009251|gb|EFA05699.1| serine protease P155 [Tribolium castaneum] -- -- -- -- -- K08664 PRSS8 protease, serine, 8 (prostasin) http://www.genome.jp/dbget-bin/www_bget?ko:K08664 Q9ESD1 348 2.3e-31 Prostasin OS=Mus musculus GN=Prss8 PE=2 SV=2 PF00089//PF01418 Trypsin//Helix-turn-helix domain, rpiR family GO:0006508//GO:0006355 proteolysis//regulation of transcription, DNA-templated GO:0004252//GO:0003700//GO:0008233 serine-type endopeptidase activity//transcription factor activity, sequence-specific DNA binding//peptidase activity GO:0005667 transcription factor complex -- -- Cluster-8309.51571 BF_2 2.12 0.31 572 826406972 XP_012537234.1 212 9.7e-15 PREDICTED: fatty acid synthase-like, partial [Monomorium pharaonis] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P49327 171 2.3e-11 Fatty acid synthase OS=Homo sapiens GN=FASN PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.51572 BF_2 246.50 2.77 4007 642922588 XP_008193239.1 1439 3.6e-156 PREDICTED: protein AF-10 isoform X2 [Tribolium castaneum] 642922589 XM_008195018.1 320 2.36023e-164 PREDICTED: Tribolium castaneum protein AF-10 (LOC658502), transcript variant X6, mRNA -- -- -- -- P55197 839 5.5e-88 Protein AF-10 OS=Homo sapiens GN=MLLT10 PE=1 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG0956 PHD finger protein AF10 Cluster-8309.51574 BF_2 10.00 1.35 598 91094481 XP_970829.1 165 2.9e-09 PREDICTED: WD and tetratricopeptide repeats protein 1 [Tribolium castaneum]>gi|270000741|gb|EEZ97188.1| hypothetical protein TcasGA2_TC004375 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51575 BF_2 204.39 6.45 1613 642940167 XP_008194639.1 623 6.0e-62 PREDICTED: leucine-rich repeat-containing protein 15-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXM1 253 2.0e-20 Leucine-rich repeats and immunoglobulin-like domains protein 3 OS=Homo sapiens GN=LRIG3 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.51579 BF_2 227.00 2.82 3660 332374070 AEE62176.1 1027 1.9e-108 unknown [Dendroctonus ponderosae] -- -- -- -- -- K12259 SMOX, PAO5 spermine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K12259 Q9NWM0 382 5.0e-35 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01266//PF07992//PF06152//PF00070//PF01593//PF12831 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Phage minor capsid protein 2//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase GO:0055114 oxidation-reduction process GO:0005198//GO:0016491 structural molecule activity//oxidoreductase activity GO:0019028 viral capsid KOG0685 Flavin-containing amine oxidase Cluster-8309.5158 BF_2 5.25 0.42 814 170028307 XP_001842037.1 270 2.6e-21 lysosomal acid lipase [Culex quinquefasciatus]>gi|167874192|gb|EDS37575.1| lysosomal acid lipase [Culex quinquefasciatus] -- -- -- -- -- K01046 E3.1.1.3 triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K01046 O46108 216 2.0e-16 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51586 BF_2 81.16 1.18 3159 332373870 AEE62076.1 1581 9.7e-173 unknown [Dendroctonus ponderosae] 198456406 XM_001360273.2 35 5.00327e-06 Drosophila pseudoobscura pseudoobscura GA13487 (Dpse\GA13487), partial mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 909 3.3e-96 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.51587 BF_2 24.48 0.34 3281 332373870 AEE62076.1 1581 1.0e-172 unknown [Dendroctonus ponderosae] 198456406 XM_001360273.2 35 5.19872e-06 Drosophila pseudoobscura pseudoobscura GA13487 (Dpse\GA13487), partial mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 909 3.5e-96 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.51591 BF_2 17.58 0.51 1740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51592 BF_2 1.00 1.13 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51593 BF_2 8.79 0.69 818 189234785 XP_975008.2 818 7.5e-85 PREDICTED: acetyl-CoA acetyltransferase, mitochondrial [Tribolium castaneum]>gi|270001523|gb|EEZ97970.1| hypothetical protein TcasGA2_TC000365 [Tribolium castaneum] -- -- -- -- -- K00626 E2.3.1.9, atoB acetyl-CoA C-acetyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00626 P17764 425 1.1e-40 Acetyl-CoA acetyltransferase, mitochondrial OS=Rattus norvegicus GN=Acat1 PE=1 SV=1 PF03534//PF02803//PF00462 Salmonella virulence plasmid 65kDa B protein//Thiolase, C-terminal domain//Glutaredoxin GO:0008152//GO:0006118//GO:0045454 metabolic process//obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055//GO:0016747 protein disulfide oxidoreductase activity//electron carrier activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0005737 cytoplasm KOG1390 Acetyl-CoA acetyltransferase Cluster-8309.51594 BF_2 7.75 0.33 1281 270009969 EFA06417.1 347 4.8e-30 hypothetical protein TcasGA2_TC009296 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.51604 BF_2 28.62 0.41 3175 546679384 ERL89859.1 2202 9.5e-245 hypothetical protein D910_07218, partial [Dendroctonus ponderosae] -- -- -- -- -- K11421 SETDB1 histone-lysine N-methyltransferase SETDB1 http://www.genome.jp/dbget-bin/www_bget?ko:K11421 Q28Z18 942 5.0e-100 Histone-lysine N-methyltransferase eggless OS=Drosophila pseudoobscura pseudoobscura GN=egg PE=3 SV=2 PF00856//PF05033//PF01429 SET domain//Pre-SET motif//Methyl-CpG binding domain GO:0034968//GO:0006479//GO:0006554 histone lysine methylation//protein methylation//lysine catabolic process GO:0003677//GO:0018024//GO:0005515//GO:0008270 DNA binding//histone-lysine N-methyltransferase activity//protein binding//zinc ion binding GO:0005634 nucleus KOG1141 Predicted histone methyl transferase Cluster-8309.51608 BF_2 306.99 2.98 4602 642925191 XP_008194463.1 3175 0.0e+00 PREDICTED: myelin regulatory factor isoform X4 [Tribolium castaneum]>gi|270008766|gb|EFA05214.1| hypothetical protein TcasGA2_TC015354 [Tribolium castaneum] 641655935 XM_008181560.1 95 3.23893e-39 PREDICTED: Acyrthosiphon pisum myelin regulatory factor (LOC103308338), mRNA -- -- -- -- Q9Y2G1 1228 5.0e-133 Myelin regulatory factor OS=Homo sapiens GN=MYRF PE=1 SV=3 PF05224//PF10152 NDT80 / PhoG like DNA-binding family//Predicted coiled-coil domain-containing protein (DUF2360) -- -- GO:0003677 DNA binding GO:0071203 WASH complex KOG3661 Uncharacterized conserved protein Cluster-8309.51610 BF_2 13.46 0.56 1287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51614 BF_2 213.92 4.76 2168 189238634 XP_001811204.1 2185 6.1e-243 PREDICTED: tubulin gamma-1 chain isoform X2 [Tribolium castaneum] 675658452 XM_002747994.2 219 1.77326e-108 PREDICTED: Callithrix jacchus tubulin, gamma 1 (TUBG1), mRNA K10389 TUBG tubulin gamma http://www.genome.jp/dbget-bin/www_bget?ko:K10389 Q0VCD2 1927 2.1e-214 Tubulin gamma-1 chain OS=Bos taurus GN=TUBG1 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1374 Gamma tubulin Cluster-8309.51615 BF_2 52.32 0.93 2629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51616 BF_2 148.68 2.64 2644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51620 BF_2 166.60 2.99 2617 270017034 EFA13480.1 707 1.8e-71 hypothetical protein TcasGA2_TC002031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MU95 275 9.0e-23 Beta-1,3-glucan-binding protein OS=Plodia interpunctella PE=1 SV=1 PF15886 Carbohydrate binding domain (family 32) -- -- GO:0030246 carbohydrate binding -- -- -- -- Cluster-8309.51622 BF_2 60.33 1.40 2092 478253546 ENN73864.1 744 7.3e-76 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] -- -- -- -- -- K11996 MOCS3, UBA4, moeB adenylyltransferase and sulfurtransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11996 Q17CA7 634 1.7e-64 Adenylyltransferase and sulfurtransferase MOCS3 OS=Aedes aegypti GN=AAEL004607 PE=3 SV=1 PF03435//PF01266//PF13241//PF02558//PF01134//PF00899//PF03721//PF00070//PF01494//PF07992//PF02254 Saccharopine dehydrogenase NADP binding domain//FAD dependent oxidoreductase//Putative NAD(P)-binding//Ketopantoate reductase PanE/ApbA//Glucose inhibited division protein A//ThiF family//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//TrkA-N domain GO:0055114//GO:0008033//GO:0006779//GO:0006813//GO:0019354//GO:0015940 oxidation-reduction process//tRNA processing//porphyrin-containing compound biosynthetic process//potassium ion transport//siroheme biosynthetic process//pantothenate biosynthetic process GO:0008641//GO:0050660//GO:0008677//GO:0051287//GO:0016616//GO:0016491//GO:0071949//GO:0043115 small protein activating enzyme activity//flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//FAD binding//precorrin-2 dehydrogenase activity -- -- KOG2017 Molybdopterin synthase sulfurylase Cluster-8309.51624 BF_2 9.97 2.17 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51628 BF_2 21.97 2.52 652 642924886 XP_008194084.1 416 2.4e-38 PREDICTED: serine/threonine-protein kinase MST4 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08838 STK24_25_MST4 serine/threonine-protein kinase 24/25/MST4 http://www.genome.jp/dbget-bin/www_bget?ko:K08838 -- -- -- -- PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- -- -- Cluster-8309.5163 BF_2 40.23 1.30 1585 642929142 XP_008195711.1 1656 9.7e-182 PREDICTED: transcription factor AP-2 isoform X1 [Tribolium castaneum] 597797984 XM_007260483.1 100 1.82746e-42 PREDICTED: Astyanax mexicanus transcription factor AP-2 beta (activating enhancer binding protein 2 beta) (tfap2b), mRNA K09179 TFAP2E transcription factor AP-2 epsilon http://www.genome.jp/dbget-bin/www_bget?ko:K09179 Q2T9K2 867 1.2e-91 Transcription factor AP-2-epsilon OS=Xenopus laevis GN=tfap2e PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3811 Transcription factor AP-2 Cluster-8309.51630 BF_2 293.97 9.83 1538 642924864 XP_008194073.1 138 9.9e-06 PREDICTED: uncharacterized protein LOC656855 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51632 BF_2 123.68 2.26 2572 642916217 XP_008190934.1 3030 0.0e+00 PREDICTED: calpain-C [Tribolium castaneum] 195479179 XM_002100759.1 39 2.42969e-08 Drosophila yakuba GE17262 (Dyak\GE17262), partial mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 Q9VXH6 1662 1.3e-183 Calpain-C OS=Drosophila melanogaster GN=CalpC PE=1 SV=4 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.51641 BF_2 25.24 0.52 2306 642919263 XP_008191800.1 985 9.1e-104 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8NFU1 646 7.6e-66 Bestrophin-2 OS=Homo sapiens GN=BEST2 PE=2 SV=1 PF08283 Geminivirus rep protein central domain GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.51644 BF_2 85.14 4.71 1043 478256686 ENN76868.1 708 5.4e-72 hypothetical protein YQE_06709, partial [Dendroctonus ponderosae]>gi|546685117|gb|ERL94644.1| hypothetical protein D910_11919 [Dendroctonus ponderosae] -- -- -- -- -- K00944 AK3 nucleoside-triphosphate--adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00944 Q9WTP7 485 1.6e-47 GTP:AMP phosphotransferase AK3, mitochondrial OS=Mus musculus GN=Ak3 PE=1 SV=3 PF05191 Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0004017 adenylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.51645 BF_2 317.70 3.32 4295 642919071 XP_008191721.1 4744 0.0e+00 PREDICTED: MAP kinase-activating death domain protein isoform X2 [Tribolium castaneum] 780680996 XM_011699227.1 91 5.05546e-37 PREDICTED: Wasmannia auropunctata MAP kinase-activating death domain protein (LOC105455707), transcript variant X7, mRNA -- -- -- -- Q9VXY2 3272 0.0e+00 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane KOG3570 MAPK-activating protein DENN Cluster-8309.51646 BF_2 54.41 0.55 4392 642919071 XP_008191721.1 3346 0.0e+00 PREDICTED: MAP kinase-activating death domain protein isoform X2 [Tribolium castaneum] 780680996 XM_011699227.1 91 5.1706e-37 PREDICTED: Wasmannia auropunctata MAP kinase-activating death domain protein (LOC105455707), transcript variant X7, mRNA -- -- -- -- Q9VXY2 2480 3.1e-278 MAP kinase-activating death domain protein OS=Drosophila melanogaster GN=rab3-GEF PE=2 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane KOG3570 MAPK-activating protein DENN Cluster-8309.51647 BF_2 99.53 1.00 4449 546682907 ERL92786.1 1051 3.9e-111 hypothetical protein D910_10094 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P53184 285 1.1e-23 Nicotinamidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNC1 PE=1 SV=1 PF00857//PF13202//PF00036//PF09402//PF12861//PF00412//PF12763//PF10591//PF13405//PF13833//PF13499 Isochorismatase family//EF hand//EF hand//Man1-Src1p-C-terminal domain//Anaphase-promoting complex subunit 11 RING-H2 finger//LIM domain//Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF-hand domain pair GO:0007165//GO:0008152//GO:0016567 signal transduction//metabolic process//protein ubiquitination GO:0005509//GO:0008270//GO:0003824//GO:0004842//GO:0005515 calcium ion binding//zinc ion binding//catalytic activity//ubiquitin-protein transferase activity//protein binding GO:0005578//GO:0005639//GO:0005680 proteinaceous extracellular matrix//integral component of nuclear inner membrane//anaphase-promoting complex KOG4003 Pyrazinamidase/nicotinamidase PNC1 Cluster-8309.51648 BF_2 12.16 0.39 1599 642935798 XP_008198179.1 358 3.2e-31 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- K06489 CD53, MOX44, TSPAN25 CD53 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06489 Q2KHY8 146 5.0e-08 Leukocyte antigen CD37 OS=Bos taurus GN=CD37 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51653 BF_2 148.85 1.55 4292 91084565 XP_973665.1 3728 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 41 homolog [Tribolium castaneum]>gi|270008656|gb|EFA05104.1| hypothetical protein TcasGA2_TC015204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5KU39 1694 4.3e-187 Vacuolar protein sorting-associated protein 41 homolog OS=Mus musculus GN=Vps41 PE=2 SV=1 PF17122//PF00400//PF14634//PF12678//PF17123//PF00637//PF13639 Zinc-finger//WD domain, G-beta repeat//zinc-RING finger domain//RING-H2 zinc finger//RING-like zinc finger//Region in Clathrin and VPS//Ring finger domain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005622 intracellular KOG2066 Vacuolar assembly/sorting protein VPS41 Cluster-8309.51654 BF_2 604.21 6.49 4183 91084565 XP_973665.1 3739 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 41 homolog [Tribolium castaneum]>gi|270008656|gb|EFA05104.1| hypothetical protein TcasGA2_TC015204 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5KU39 1694 4.2e-187 Vacuolar protein sorting-associated protein 41 homolog OS=Mus musculus GN=Vps41 PE=2 SV=1 PF17123//PF12678//PF14634//PF00400//PF17122//PF13639//PF00637 RING-like zinc finger//RING-H2 zinc finger//zinc-RING finger domain//WD domain, G-beta repeat//Zinc-finger//Ring finger domain//Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005622 intracellular KOG2066 Vacuolar assembly/sorting protein VPS41 Cluster-8309.51655 BF_2 62.40 1.17 2515 642933990 XP_008197594.1 414 1.6e-37 PREDICTED: vesicle-fusing ATPase 1-like [Tribolium castaneum]>gi|642933992|ref|XP_008197595.1| PREDICTED: vesicle-fusing ATPase 1-like [Tribolium castaneum]>gi|270013652|gb|EFA10100.1| hypothetical protein TcasGA2_TC012279 [Tribolium castaneum] -- -- -- -- -- K06027 NSF vesicle-fusing ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K06027 P46461 305 2.9e-26 Vesicle-fusing ATPase 1 OS=Drosophila melanogaster GN=comt PE=2 SV=1 PF08752//PF01299 Coatomer gamma subunit appendage platform subdomain//Lysosome-associated membrane glycoprotein (Lamp) GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005524//GO:0017111//GO:0005198 ATP binding//nucleoside-triphosphatase activity//structural molecule activity GO:0016020//GO:0030126 membrane//COPI vesicle coat -- -- Cluster-8309.51656 BF_2 698.78 10.24 3141 91083297 XP_974591.1 1894 4.9e-209 PREDICTED: probable cysteine desulfurase, mitochondrial [Tribolium castaneum]>gi|270007737|gb|EFA04185.1| hypothetical protein TcasGA2_TC014434 [Tribolium castaneum] -- -- -- -- -- K04487 iscS, NFS1 cysteine desulfurase http://www.genome.jp/dbget-bin/www_bget?ko:K04487 Q9VKD3 1773 2.2e-196 Probable cysteine desulfurase, mitochondrial OS=Drosophila melanogaster GN=CG12264 PE=2 SV=1 PF01926//PF08477//PF00025//PF03193//PF00910//PF04670//PF00071//PF00282//PF01212 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family//Protein of unknown function, DUF258//RNA helicase//Gtr1/RagA G protein conserved region//Ras family//Pyridoxal-dependent decarboxylase conserved domain//Beta-eliminating lyase GO:0008152//GO:0019752//GO:0007264//GO:0006520 metabolic process//carboxylic acid metabolic process//small GTPase mediated signal transduction//cellular amino acid metabolic process GO:0003723//GO:0003824//GO:0016831//GO:0030170//GO:0003924//GO:0005525//GO:0003724//GO:0016829 RNA binding//catalytic activity//carboxy-lyase activity//pyridoxal phosphate binding//GTPase activity//GTP binding//RNA helicase activity//lyase activity -- -- KOG1549 Cysteine desulfurase NFS1 Cluster-8309.5166 BF_2 16.00 3.89 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51660 BF_2 30.35 0.32 4301 270017202 EFA13648.1 1610 5.7e-176 hypothetical protein TcasGA2_TC015886 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P30028 175 5.9e-11 Protein P OS=Duck hepatitis B virus (strain China) GN=P PE=3 SV=1 PF05869//PF00201 DNA N-6-adenine-methyltransferase (Dam)//UDP-glucoronosyl and UDP-glucosyl transferase GO:0006306//GO:0008152//GO:0032775 DNA methylation//metabolic process//DNA methylation on adenine GO:0009007//GO:0016758//GO:0003677 site-specific DNA-methyltransferase (adenine-specific) activity//transferase activity, transferring hexosyl groups//DNA binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.51666 BF_2 93.27 12.97 588 270004298 EFA00746.1 810 4.5e-84 hypothetical protein TcasGA2_TC003628 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BVD5 440 1.5e-42 MAGUK p55 subfamily member 7 OS=Mus musculus GN=Mpp7 PE=2 SV=2 PF14604//PF00595//PF00018//PF13180 Variant SH3 domain//PDZ domain (Also known as DHR or GLGF)//SH3 domain//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51667 BF_2 104.20 0.50 8979 642916561 XP_008191701.1 2302 6.8e-256 PREDICTED: uncharacterized protein LOC100142540 [Tribolium castaneum] 642916712 XM_001813000.2 329 5.27571e-169 PREDICTED: Tribolium castaneum protein bric-a-brac 1-like (LOC100141653), mRNA -- -- -- -- Q5T2T1 1155 2.8e-124 MAGUK p55 subfamily member 7 OS=Homo sapiens GN=MPP7 PE=1 SV=1 PF05225//PF13180//PF00651//PF00018//PF14604//PF00595 helix-turn-helix, Psq domain//PDZ domain//BTB/POZ domain//SH3 domain//Variant SH3 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0609 Calcium/calmodulin-dependent serine protein kinase/membrane-associated guanylate kinase Cluster-8309.51670 BF_2 198.32 1.03 8343 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.68467e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF10233//PF01059//PF09606//PF00400//PF00472//PF16692 Uncharacterized conserved protein CG6151-P//NADH-ubiquinone oxidoreductase chain 4, amino terminus//ARC105 or Med15 subunit of Mediator complex non-fungal//WD domain, G-beta repeat//RF-1 domain//Folliculin C-terminal domain GO:0006449//GO:0006120//GO:0055114//GO:0006357//GO:0043087//GO:0006415 regulation of translational termination//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//regulation of transcription from RNA polymerase II promoter//regulation of GTPase activity//translational termination GO:0005515//GO:0005085//GO:0003747//GO:0001104 protein binding//guanyl-nucleotide exchange factor activity//translation release factor activity//RNA polymerase II transcription cofactor activity GO:0016592//GO:0016021//GO:0018444//GO:0005840 mediator complex//integral component of membrane//translation release factor complex//ribosome KOG3154 Uncharacterized conserved protein Cluster-8309.51671 BF_2 55.53 0.49 5020 642912389 XP_008199486.1 3429 0.0e+00 PREDICTED: liprin-alpha-1 isoform X4 [Tribolium castaneum] 642912388 XM_008201264.1 862 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X4, mRNA -- -- -- -- Q13136 1554 8.5e-171 Liprin-alpha-1 OS=Homo sapiens GN=PPFIA1 PE=1 SV=1 PF05513//PF02459 TraA//Adenoviral DNA terminal protein GO:0000746//GO:0006260 conjugation//DNA replication GO:0003677 DNA binding GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.51673 BF_2 210.50 2.04 4609 478261315 ENN80731.1 2577 4.5e-288 hypothetical protein YQE_02839, partial [Dendroctonus ponderosae] 391330831 XM_003739808.1 45 2.02262e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q7TSH8 909 4.9e-96 Uncharacterized protein KIAA0195 OS=Mus musculus GN=Kiaa0195 PE=2 SV=1 PF01844//PF00122 HNH endonuclease//E1-E2 ATPase -- -- GO:0003676//GO:0000166//GO:0004519//GO:0046872 nucleic acid binding//nucleotide binding//endonuclease activity//metal ion binding -- -- KOG4383 Uncharacterized conserved protein Cluster-8309.51678 BF_2 281.98 11.45 1317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51679 BF_2 8.09 1.94 461 91079594 XP_967887.1 181 3.1e-11 PREDICTED: probable E3 ubiquitin-protein ligase RNF144A isoform X1 [Tribolium castaneum]>gi|270003396|gb|EEZ99843.1| hypothetical protein TcasGA2_TC002624 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51680 BF_2 2.00 0.79 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51683 BF_2 140.54 0.77 7929 641658099 XP_008180596.1 937 1.2e-97 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] 642920823 XM_008194352.1 69 1.58941e-24 PREDICTED: Tribolium castaneum transcription factor SPT20 homolog (LOC661459), transcript variant X2, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 886 3.9e-93 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF00096//PF16622//PF12090//PF13912//PF02892//PF00412//PF12833//PF04810//PF13465 Zinc finger, C2H2 type//zinc-finger C2H2-type//Spt20 family//C2H2-type zinc finger//BED zinc finger//LIM domain//Helix-turn-helix domain//Sec23/Sec24 zinc finger//Zinc-finger double domain GO:0006888//GO:0006886//GO:0006355 ER to Golgi vesicle-mediated transport//intracellular protein transport//regulation of transcription, DNA-templated GO:0003677//GO:0043565//GO:0003712//GO:0008270//GO:0046872//GO:0003700 DNA binding//sequence-specific DNA binding//transcription cofactor activity//zinc ion binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0030127//GO:0005667//GO:0000124 COPII vesicle coat//transcription factor complex//SAGA complex -- -- Cluster-8309.51684 BF_2 77.57 1.81 2082 546683632 ERL93420.1 963 2.9e-101 hypothetical protein D910_10712 [Dendroctonus ponderosae] -- -- -- -- -- K02157 AXIN1 axin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02157 Q9V407 259 5.2e-21 Axin OS=Drosophila melanogaster GN=Axn PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51689 BF_2 25.00 0.33 3418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51690 BF_2 69856.12 1590.04 2125 315570560 ADU33284.1 2397 1.6e-267 glycoside hydrolase family protein 48 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P50899 1926 2.6e-214 Exoglucanase B OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) GN=cbhB PE=1 SV=1 PF02011 Glycosyl hydrolase family 48 GO:0030245//GO:0005975//GO:0005982//GO:0005985 cellulose catabolic process//carbohydrate metabolic process//starch metabolic process//sucrose metabolic process GO:0008810//GO:0004553 cellulase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.51695 BF_2 67.58 0.62 4841 675371881 KFM64783.1 284 3.7e-22 Hypothetical protein in type-1 retrotransposable element R1DM, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P16425 223 1.8e-16 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 PF01609 Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.51698 BF_2 13.74 0.32 2057 546676350 ERL87377.1 1897 1.4e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.2e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.51699 BF_2 362.60 1.86 8424 642929587 XP_975389.2 4308 0.0e+00 PREDICTED: uncharacterized protein LOC664289 isoform X3 [Tribolium castaneum] 642929586 XM_970296.2 70 4.69634e-25 PREDICTED: Tribolium castaneum uncharacterized LOC664289 (LOC664289), transcript variant X3, mRNA -- -- -- -- Q14687 146 2.6e-07 Genetic suppressor element 1 OS=Homo sapiens GN=GSE1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51700 BF_2 113.47 2.88 1936 642917151 XP_008191139.1 2389 1.2e-266 PREDICTED: F-box-like/WD repeat-containing protein TBL1XR1 [Tribolium castaneum]>gi|270004371|gb|EFA00819.1| hypothetical protein TcasGA2_TC003706 [Tribolium castaneum] 442624961 NM_057981.4 286 8.98813e-146 Drosophila melanogaster ebi (ebi), mRNA K04508 TBL1 transducin (beta)-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04508 Q8BHJ5 2046 2.9e-228 F-box-like/WD repeat-containing protein TBL1XR1 OS=Mus musculus GN=Tbl1xr1 PE=1 SV=1 PF04053//PF08513//PF00457//PF00400//PF01588 Coatomer WD associated region//LisH//Glycosyl hydrolases family 11//WD domain, G-beta repeat//Putative tRNA binding domain GO:0016192//GO:0006886//GO:0005975 vesicle-mediated transport//intracellular protein transport//carbohydrate metabolic process GO:0005515//GO:0000049//GO:0005198//GO:0004553 protein binding//tRNA binding//structural molecule activity//hydrolase activity, hydrolyzing O-glycosyl compounds GO:0030117 membrane coat KOG0273 Beta-transducin family (WD-40 repeat) protein Cluster-8309.51703 BF_2 176.74 0.64 11875 478250833 ENN71323.1 994 4.2e-104 hypothetical protein YQE_11983, partial [Dendroctonus ponderosae]>gi|478259213|gb|ENN79116.1| hypothetical protein YQE_04427, partial [Dendroctonus ponderosae] 642918718 XM_008193332.1 122 8.21846e-54 PREDICTED: Tribolium castaneum zinc finger protein jing homolog (LOC658276), transcript variant X2, mRNA K17452 AEBP2 zinc finger protein AEBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K17452 Q17PR1 474 3.5e-45 Zinc finger protein jing homolog OS=Aedes aegypti GN=AAEL000263 PE=3 SV=1 PF05399//PF16622//PF13465//PF00096 Ectropic viral integration site 2A protein (EVI2A)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.51706 BF_2 3.00 1.75 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51707 BF_2 26924.00 512.69 2484 27450390 AAO14612.1 1933 1.2e-213 alpha-amylase [Blaps mucronata] 153926498 AK283612.1 75 2.27997e-28 Gryllus bimaculatus mRNA, GBcontig30473 K01176 E3.2.1.1, amyA, malS alpha-amylase http://www.genome.jp/dbget-bin/www_bget?ko:K01176 P09107 1865 3.7e-207 Alpha-amylase (Fragment) OS=Tribolium castaneum PE=3 SV=2 PF00128//PF02806 Alpha amylase, catalytic domain//Alpha amylase, C-terminal all-beta domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169 catalytic activity//cation binding -- -- KOG2212 Alpha-amylase Cluster-8309.51708 BF_2 103.13 3.12 1670 728418241 AIY68362.1 1002 7.0e-106 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P12992 413 5.7e-39 Juvenile hormone esterase OS=Heliothis virescens PE=1 SV=2 PF00326//PF07859//PF13409 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Glutathione S-transferase, N-terminal domain GO:0008152//GO:0006508 metabolic process//proteolysis GO:0005515//GO:0008236//GO:0016787 protein binding//serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.5171 BF_2 3.00 0.36 634 478258611 ENN78661.1 429 7.4e-40 hypothetical protein YQE_04833, partial [Dendroctonus ponderosae]>gi|546685768|gb|ERL95217.1| hypothetical protein D910_12484 [Dendroctonus ponderosae] 752872390 XM_011255128.1 52 3.41081e-16 PREDICTED: Camponotus floridanus endocuticle structural glycoprotein SgAbd-1-like (LOC105249568), mRNA -- -- -- -- Q7M4F4 282 3.4e-24 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.51712 BF_2 267.51 2.22 5332 642918616 XP_008200343.1 2086 4.5e-231 PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum]>gi|642918618|ref|XP_008200351.1| PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum] 462322041 APGK01042995.1 78 1.0594e-29 Dendroctonus ponderosae Seq01043005, whole genome shotgun sequence -- -- -- -- Q61SK8 473 2.0e-45 MOG interacting and ectopic P-granules protein 1 OS=Caenorhabditis briggsae GN=mep-1 PE=3 SV=2 PF04692//PF13912//PF13465//PF00096 Platelet-derived growth factor, N terminal region//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0046872//GO:0008083 metal ion binding//growth factor activity GO:0016020 membrane -- -- Cluster-8309.51713 BF_2 445.24 3.76 5236 642918616 XP_008200343.1 2133 1.6e-236 PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum]>gi|642918618|ref|XP_008200351.1| PREDICTED: MOG interacting and ectopic P-granules protein 1 isoform X1 [Tribolium castaneum] 462322041 APGK01042995.1 78 1.0402e-29 Dendroctonus ponderosae Seq01043005, whole genome shotgun sequence -- -- -- -- Q21502 458 1.1e-43 MOG interacting and ectopic P-granules protein 1 OS=Caenorhabditis elegans GN=mep-1 PE=1 SV=2 PF13912//PF04692//PF00096//PF13465 C2H2-type zinc finger//Platelet-derived growth factor, N terminal region//Zinc finger, C2H2 type//Zinc-finger double domain GO:0007165//GO:0040007//GO:0008283 signal transduction//growth//cell proliferation GO:0008083//GO:0046872 growth factor activity//metal ion binding GO:0016020 membrane -- -- Cluster-8309.51714 BF_2 108.39 0.53 8791 478255320 ENN75546.1 1154 8.8e-123 hypothetical protein YQE_07889, partial [Dendroctonus ponderosae] 462322041 APGK01042995.1 78 1.75059e-29 Dendroctonus ponderosae Seq01043005, whole genome shotgun sequence -- -- -- -- Q61SK8 296 1.1e-24 MOG interacting and ectopic P-granules protein 1 OS=Caenorhabditis briggsae GN=mep-1 PE=3 SV=2 PF00096//PF00253//PF04988//PF13465//PF04692//PF13912//PF15178//PF01530//PF05191//PF16622 Zinc finger, C2H2 type//Ribosomal protein S14p/S29e//A-kinase anchoring protein 95 (AKAP95)//Zinc-finger double domain//Platelet-derived growth factor, N terminal region//C2H2-type zinc finger//Mitochondrial import receptor subunit TOM5 homolog//Zinc finger, C2HC type//Adenylate kinase, active site lid//zinc-finger C2H2-type GO:0042254//GO:0006355//GO:0046034//GO:0007165//GO:0006144//GO:0006412//GO:0008283//GO:0040007 ribosome biogenesis//regulation of transcription, DNA-templated//ATP metabolic process//signal transduction//purine nucleobase metabolic process//translation//cell proliferation//growth GO:0003700//GO:0004017//GO:0003735//GO:0008270//GO:0046872//GO:0003677//GO:0008083 transcription factor activity, sequence-specific DNA binding//adenylate kinase activity//structural constituent of ribosome//zinc ion binding//metal ion binding//DNA binding//growth factor activity GO:0005742//GO:0005840//GO:0005622//GO:0016020//GO:0005667//GO:0005634 mitochondrial outer membrane translocase complex//ribosome//intracellular//membrane//transcription factor complex//nucleus -- -- Cluster-8309.51716 BF_2 103.00 3.08 1688 270010271 EFA06719.1 335 1.6e-28 hypothetical protein TcasGA2_TC009650 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51717 BF_2 965.74 9.61 4490 642917912 XP_008191379.1 1326 5.1e-143 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 555 5.3e-55 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.51719 BF_2 66.27 1.02 3012 270013391 EFA09839.1 4485 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 366 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- P31695 484 6.1e-47 Neurogenic locus notch homolog protein 4 OS=Mus musculus GN=Notch4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.51721 BF_2 440.99 5.72 3515 478255701 ENN75912.1 1275 3.3e-137 hypothetical protein YQE_07554, partial [Dendroctonus ponderosae] 817199099 XM_012419796.1 144 1.42354e-66 PREDICTED: Orussus abietinus transmembrane protein 189 (LOC105696934), transcript variant X3, mRNA K10704 UBE2V ubiquitin-conjugating enzyme E2 variant http://www.genome.jp/dbget-bin/www_bget?ko:K10704 A6QLM0 813 5.0e-85 Transmembrane protein 189 OS=Bos taurus GN=TMEM189 PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0055114//GO:0006633 oxidation-reduction process//fatty acid biosynthetic process GO:0016491//GO:0005506 oxidoreductase activity//iron ion binding -- -- KOG3011 Ubiquitin-conjugating enzyme Cluster-8309.51723 BF_2 5.00 1.21 460 646723380 KDR24014.1 178 6.8e-11 hypothetical protein L798_07957, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51726 BF_2 25.60 2.43 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51728 BF_2 16.39 0.32 2434 642923235 XP_008193669.1 175 8.1e-10 PREDICTED: folliculin-interacting protein 1 [Tribolium castaneum]>gi|270007081|gb|EFA03529.1| hypothetical protein TcasGA2_TC013532 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51729 BF_2 66.80 1.11 2813 642915596 XP_008190681.1 1038 7.9e-110 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B-B [Tribolium castaneum] -- -- -- -- -- K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 Q3TTA7 152 1.8e-08 E3 ubiquitin-protein ligase CBL-B OS=Mus musculus GN=Cblb PE=1 SV=3 PF02796 Helix-turn-helix domain of resolvase GO:0006310 DNA recombination GO:0000150//GO:0003677 recombinase activity//DNA binding -- -- -- -- Cluster-8309.51730 BF_2 524.76 3.83 6016 642915596 XP_008190681.1 2238 1.2e-248 PREDICTED: LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B-B [Tribolium castaneum] 801389704 XM_012201966.1 201 5.04071e-98 PREDICTED: Atta cephalotes E3 ubiquitin-protein ligase CBL-B (LOC105620476), transcript variant X3, mRNA K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 P22681 1636 3.2e-180 E3 ubiquitin-protein ligase CBL OS=Homo sapiens GN=CBL PE=1 SV=2 PF13639//PF02262//PF02761//PF00097//PF12678//PF14634//PF02796 Ring finger domain//CBL proto-oncogene N-terminal domain 1//CBL proto-oncogene N-terminus, EF hand-like domain//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain//Helix-turn-helix domain of resolvase GO:0006310//GO:0007166//GO:0007165 DNA recombination//cell surface receptor signaling pathway//signal transduction GO:0005509//GO:0008270//GO:0004871//GO:0046872//GO:0003677//GO:0000150//GO:0005515 calcium ion binding//zinc ion binding//signal transducer activity//metal ion binding//DNA binding//recombinase activity//protein binding GO:0005634 nucleus KOG1785 Tyrosine kinase negative regulator CBL Cluster-8309.51731 BF_2 27.44 0.51 2538 478253028 ENN73408.1 1589 9.2e-174 hypothetical protein YQE_09970, partial [Dendroctonus ponderosae] 801389704 XM_012201966.1 126 1.0391e-56 PREDICTED: Atta cephalotes E3 ubiquitin-protein ligase CBL-B (LOC105620476), transcript variant X3, mRNA K04707 CBL E3 ubiquitin-protein ligase CBL http://www.genome.jp/dbget-bin/www_bget?ko:K04707 Q13191 1160 2.1e-125 E3 ubiquitin-protein ligase CBL-B OS=Homo sapiens GN=CBLB PE=1 SV=2 PF02262//PF02761 CBL proto-oncogene N-terminal domain 1//CBL proto-oncogene N-terminus, EF hand-like domain GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0004871//GO:0005509 signal transducer activity//calcium ion binding GO:0005634 nucleus KOG1785 Tyrosine kinase negative regulator CBL Cluster-8309.51733 BF_2 213.50 2.96 3301 91079957 XP_969398.1 635 5.0e-63 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6L5 146 1.0e-07 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51734 BF_2 288.56 5.27 2577 91079957 XP_969398.1 506 3.5e-48 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51740 BF_2 1557.00 25.41 2850 300394172 ADK11712.1 183 1.1e-10 aminopeptidase N [Sitophilus oryzae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.51742 BF_2 818.00 21.31 1893 634007010 AHZ59670.1 1270 6.7e-137 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1052 5.2e-113 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.51744 BF_2 39662.14 1081.70 1821 728418241 AIY68362.1 1042 1.8e-110 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P12992 434 2.3e-41 Juvenile hormone esterase OS=Heliothis virescens PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51746 BF_2 25.54 0.40 2930 642933293 XP_968154.2 806 6.6e-83 PREDICTED: putative ribosomal RNA methyltransferase CG11447 [Tribolium castaneum] -- -- -- -- -- K02427 rlmE, rrmJ, ftsJ 23S rRNA (uridine2552-2'-O)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K02427 Q9VDT6 673 7.2e-69 rRNA methyltransferase 2, mitochondrial OS=Drosophila melanogaster GN=CG11447 PE=2 SV=1 PF01728 FtsJ-like methyltransferase GO:0032259 methylation GO:0008168 methyltransferase activity -- -- KOG1099 SAM-dependent methyltransferase/cell division protein FtsJ Cluster-8309.51747 BF_2 9345.00 536.37 1016 91077308 XP_968724.1 881 4.6e-92 PREDICTED: pathogenesis-related protein 5 [Tribolium castaneum]>gi|270001657|gb|EEZ98104.1| hypothetical protein TcasGA2_TC000517 [Tribolium castaneum] 762079884 XM_011415836.1 35 1.57422e-06 PREDICTED: Crassostrea gigas thaumatin-like protein 1b (LOC105318618), mRNA -- -- -- -- P28493 572 1.3e-57 Pathogenesis-related protein 5 OS=Arabidopsis thaliana GN=At1g75040 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51749 BF_2 15.43 0.73 1176 91083575 XP_968060.1 455 1.3e-42 PREDICTED: ribonuclease H2 subunit B [Tribolium castaneum]>gi|270007823|gb|EFA04271.1| hypothetical protein TcasGA2_TC014561 [Tribolium castaneum] -- -- -- -- -- K10744 RNASEH2B ribonuclease H2 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10744 Q5HZP1 148 2.2e-08 Ribonuclease H2 subunit B OS=Xenopus laevis GN=rnaseh2b PE=2 SV=1 PF09468 Ydr279p protein family (RNase H2 complex component) -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.51751 BF_2 40.35 1.12 1792 607362518 EZA56769.1 1781 3.5e-196 hypothetical protein X777_03234 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03175 DNA polymerase type B, organellar and viral GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.51752 BF_2 3.00 1.77 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51757 BF_2 80.42 0.34 10076 759070124 XP_011344632.1 3031 0.0e+00 PREDICTED: uncharacterized protein LOC105283510 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51760 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51762 BF_2 7.00 4.52 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51763 BF_2 3323.21 140.16 1279 728418014 AIY68354.1 903 1.6e-94 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 532 7.0e-53 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.51764 BF_2 10.47 0.34 1594 546670638 ERL83322.1 416 6.0e-38 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51766 BF_2 100.56 1.60 2910 270004664 EFA01112.1 1792 3.0e-197 hypothetical protein TcasGA2_TC010324 [Tribolium castaneum] 752889233 XM_011264255.1 203 1.87276e-99 PREDICTED: Camponotus floridanus probable ATP-dependent RNA helicase DDX17 (LOC105255133), mRNA K13178 DDX17 ATP-dependent RNA helicase DDX17 http://www.genome.jp/dbget-bin/www_bget?ko:K13178 Q92841 1426 3.4e-156 Probable ATP-dependent RNA helicase DDX17 OS=Homo sapiens GN=DDX17 PE=1 SV=2 PF00270//PF00004//PF04851 DEAD/DEAH box helicase//ATPase family associated with various cellular activities (AAA)//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524 nucleic acid binding//hydrolase activity//DNA binding//ATP binding -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.51767 BF_2 363.38 4.73 3504 91094511 XP_971832.1 1240 3.7e-133 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] 645013480 XM_008206909.1 50 2.54863e-14 PREDICTED: Nasonia vitripennis heterogeneous nuclear ribonucleoprotein F-like (LOC100115988), transcript variant X3, mRNA K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 O35737 863 8.0e-91 Heterogeneous nuclear ribonucleoprotein H OS=Mus musculus GN=Hnrnph1 PE=1 SV=3 PF08777//PF00076 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0097159//GO:1901363//GO:0003676 RNA binding//organic cyclic compound binding//heterocyclic compound binding//nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.51769 BF_2 124.00 1.67 3390 224994808 NP_001139341.1 1845 2.5e-203 apterous a [Tribolium castaneum]>gi|224459212|gb|ACN43341.1| apterous a [Tribolium castaneum] 224994807 NM_001145869.1 548 0 Tribolium castaneum apterous a (LOC658656), mRNA >gnl|BL_ORD_ID|6468650 Tribolium castaneum apterous a (ap A) mRNA, complete cds K09373 LHX2_9 LIM homeobox protein 2/9 http://www.genome.jp/dbget-bin/www_bget?ko:K09373 P36198 746 2.8e-77 LIM/homeobox protein Lhx2 OS=Rattus norvegicus GN=Lhx2 PE=2 SV=1 PF00046//PF13417//PF05920//PF00412//PF08407 Homeobox domain//Glutathione S-transferase, N-terminal domain//Homeobox KN domain//LIM domain//Chitin synthase N-terminal GO:0006031//GO:0006355 chitin biosynthetic process//regulation of transcription, DNA-templated GO:0005515//GO:0004100//GO:0003677//GO:0046872//GO:0003700//GO:0008270//GO:0043565 protein binding//chitin synthase activity//DNA binding//metal ion binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0490 Transcription factor, contains HOX domain Cluster-8309.51770 BF_2 251.48 1.93 5730 642937199 XP_008198736.1 4828 0.0e+00 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 5.33696e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1968 9.6e-219 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00454//PF00168//PF00787 Phosphatidylinositol 3- and 4-kinase//C2 domain//PX domain -- -- GO:0005515//GO:0035091//GO:0016773 protein binding//phosphatidylinositol binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.51771 BF_2 76.50 1.89 1979 642122061 CDQ63792.1 197 1.8e-12 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14372//PF02083 Domain of unknown function (DUF4413)//Urotensin II GO:0007165//GO:0042312//GO:0008217 signal transduction//regulation of vasodilation//regulation of blood pressure GO:0003677//GO:0005179 DNA binding//hormone activity GO:0005576 extracellular region -- -- Cluster-8309.51772 BF_2 261.23 1.94 5910 642937199 XP_008198736.1 4828 0.0e+00 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 5.50568e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1968 9.9e-219 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00168//PF00787//PF00454 C2 domain//PX domain//Phosphatidylinositol 3- and 4-kinase -- -- GO:0016773//GO:0035091//GO:0005515 phosphotransferase activity, alcohol group as acceptor//phosphatidylinositol binding//protein binding -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.51775 BF_2 10.60 0.87 796 478252357 ENN72783.1 452 2.0e-42 hypothetical protein YQE_10588, partial [Dendroctonus ponderosae]>gi|546680689|gb|ERL90915.1| hypothetical protein D910_08259 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A4QNC6 233 2.0e-18 Protein FAM136A OS=Xenopus tropicalis GN=fam136a PE=2 SV=1 PF02970//PF07464//PF00174 Tubulin binding cofactor A//Apolipophorin-III precursor (apoLp-III)//Oxidoreductase molybdopterin binding domain GO:0007021//GO:0006869//GO:0042128 tubulin complex assembly//lipid transport//nitrate assimilation GO:0051082//GO:0015631//GO:0008289 unfolded protein binding//tubulin binding//lipid binding GO:0005576//GO:0045298 extracellular region//tubulin complex KOG3377 Uncharacterized conserved protein Cluster-8309.51776 BF_2 283.03 2.22 5621 642912926 XP_008201309.1 1747 9.7e-192 PREDICTED: LOW QUALITY PROTEIN: RNA polymerase II-associated factor 1 homolog [Tribolium castaneum] 808145633 XM_012318648.1 294 9.42754e-150 PREDICTED: Bombus terrestris RNA polymerase II-associated factor 1 homolog (LOC100650306), transcript variant X2, mRNA K15174 PAF1 RNA polymerase II-associated factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15174 B3A0N5 1263 5.3e-137 Apyrase OS=Tabanus yao PE=1 SV=1 PF03985//PF00149//PF01757//PF02872 Paf1//Calcineurin-like phosphoesterase//Acyltransferase family//5'-nucleotidase, C-terminal domain GO:0009166//GO:0016570//GO:0006368 nucleotide catabolic process//histone modification//transcription elongation from RNA polymerase II promoter GO:0016787//GO:0016747 hydrolase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016593 Cdc73/Paf1 complex KOG2478 Putative RNA polymerase II regulator Cluster-8309.51779 BF_2 141.15 1.67 3821 641654576 XP_008179259.1 844 3.4e-87 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A2T812 773 2.4e-80 Zinc finger protein 287 OS=Pongo pygmaeus GN=ZNF287 PE=3 SV=1 PF07975//PF00096//PF13465//PF16622//PF13912 TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.51783 BF_2 4.43 0.85 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51786 BF_2 1.00 23.57 213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15281 Consortin C-terminus GO:0042998 positive regulation of Golgi to plasma membrane protein transport GO:0071253 connexin binding GO:0005802 trans-Golgi network -- -- Cluster-8309.51787 BF_2 2.00 1.79 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51796 BF_2 36.57 2.36 935 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51797 BF_2 68.53 0.60 5097 642929205 XP_008195735.1 3747 0.0e+00 PREDICTED: WD repeat-containing protein 7 isoform X4 [Tribolium castaneum] 642929204 XM_008197513.1 694 0 PREDICTED: Tribolium castaneum WD repeat-containing protein 7 (LOC658806), transcript variant X5, mRNA -- -- -- -- Q920I9 1610 2.8e-177 WD repeat-containing protein 7 OS=Mus musculus GN=Wdr7 PE=1 SV=3 PF00784//PF00400//PF01506 MyTH4 domain//WD domain, G-beta repeat//Hepatitis C virus non-structural 5a protein membrane anchor GO:0006508//GO:0006144 proteolysis//purine nucleobase metabolic process GO:0004197//GO:0004252//GO:0017111//GO:0003968//GO:0005515 cysteine-type endopeptidase activity//serine-type endopeptidase activity//nucleoside-triphosphatase activity//RNA-directed RNA polymerase activity//protein binding GO:0031379//GO:0005856 RNA-directed RNA polymerase complex//cytoskeleton KOG4155 FOG: WD40 repeat Cluster-8309.51799 BF_2 882.18 4.94 7758 270001259 EEZ97706.1 4646 0.0e+00 brahma [Tribolium castaneum] 801398653 XM_012204404.1 479 0 PREDICTED: Atta cephalotes ATP-dependent helicase brm (LOC105623001), mRNA K11647 SMARCA2_4 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2/4 http://www.genome.jp/dbget-bin/www_bget?ko:K11647 P25439 3883 0.0e+00 ATP-dependent helicase brm OS=Drosophila melanogaster GN=brm PE=1 SV=2 PF00439//PF08880//PF07533//PF14619//PF00270//PF02935//PF13892//PF00176//PF04851 Bromodomain//QLQ//BRK domain//Snf2-ATP coupling, chromatin remodelling complex//DEAD/DEAH box helicase//Cytochrome c oxidase subunit VIIc//DNA-binding domain//SNF2 family N-terminal domain//Type III restriction enzyme, res subunit GO:0015992//GO:0006355//GO:0006123 proton transport//regulation of transcription, DNA-templated//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0016817//GO:0042393//GO:0003676//GO:0005515//GO:0005524//GO:0003677//GO:0016787 cytochrome-c oxidase activity//hydrolase activity, acting on acid anhydrides//histone binding//nucleic acid binding//protein binding//ATP binding//DNA binding//hydrolase activity GO:0045277//GO:0005634 respiratory chain complex IV//nucleus KOG0386 Chromatin remodeling complex SWI/SNF, component SWI2 and related ATPases (DNA/RNA helicase superfamily) Cluster-8309.51801 BF_2 1216.00 34.40 1766 478257549 ENN77703.1 413 1.5e-37 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q575T0 153 8.6e-09 Cytoglobin-1 OS=Oryzias latipes GN=cygb1 PE=2 SV=1 PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.51802 BF_2 21.98 0.39 2634 642926449 XP_008191964.1 1143 5.0e-122 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|642926451|ref|XP_008191965.1| PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270009087|gb|EFA05535.1| hypothetical protein TcasGA2_TC015722 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 538 2.9e-53 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF13495//PF00732 GMC oxidoreductase//Phage integrase, N-terminal SAM-like domain//GMC oxidoreductase GO:0015074//GO:0055114 DNA integration//oxidation-reduction process GO:0003677//GO:0050660//GO:0016614 DNA binding//flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-8309.51807 BF_2 717.39 11.66 2861 642931092 XP_008196207.1 2570 1.8e-287 PREDICTED: ATP-dependent RNA helicase DDX42 [Tribolium castaneum]>gi|270012072|gb|EFA08520.1| hypothetical protein TcasGA2_TC006173 [Tribolium castaneum] -- -- -- -- -- K12835 DDX42, SF3B125 ATP-dependent RNA helicase DDX42 http://www.genome.jp/dbget-bin/www_bget?ko:K12835 Q5F485 1661 1.9e-183 ATP-dependent RNA helicase DDX42 OS=Gallus gallus GN=DDX42 PE=2 SV=1 PF00270//PF04851 DEAD/DEAH box helicase//Type III restriction enzyme, res subunit -- -- GO:0003676//GO:0016787//GO:0003677//GO:0005524//GO:0008026 nucleic acid binding//hydrolase activity//DNA binding//ATP binding//ATP-dependent helicase activity -- -- KOG0334 RNA helicase Cluster-8309.51810 BF_2 15.00 0.88 1003 642930773 XP_008196085.1 173 5.7e-10 PREDICTED: protein msta, isoform B-like [Tribolium castaneum]>gi|270012059|gb|EFA08507.1| hypothetical protein TcasGA2_TC006159 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51811 BF_2 18.00 0.53 1719 189241889 XP_968786.2 1910 3.7e-211 PREDICTED: glutamate receptor 1 [Tribolium castaneum]>gi|270016489|gb|EFA12935.1| hypothetical protein TcasGA2_TC010481 [Tribolium castaneum] 194752016 XM_001958283.1 116 2.53226e-51 Drosophila ananassae GF10860 (Dana\GF10860), mRNA -- -- -- -- Q03445 1510 3.7e-166 Glutamate receptor 1 OS=Drosophila melanogaster GN=GluRIA PE=2 SV=2 -- -- GO:0035235//GO:0006811//GO:0007165//GO:0007268 ionotropic glutamate receptor signaling pathway//ion transport//signal transduction//synaptic transmission GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0030054//GO:0045211//GO:0016021//GO:0030288//GO:0005886 cell junction//postsynaptic membrane//integral component of membrane//outer membrane-bounded periplasmic space//plasma membrane -- -- Cluster-8309.51812 BF_2 21.15 0.39 2534 189241889 XP_968786.2 2194 6.4e-244 PREDICTED: glutamate receptor 1 [Tribolium castaneum]>gi|270016489|gb|EFA12935.1| hypothetical protein TcasGA2_TC010481 [Tribolium castaneum] 884951073 XM_010899911.2 47 8.54715e-13 PREDICTED: Esox lucius glutamate receptor, ionotropic, AMPA 2 (gria2), transcript variant X7, mRNA K05200 GRIA4 glutamate receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05200 Q03445 1509 7.1e-166 Glutamate receptor 1 OS=Drosophila melanogaster GN=GluRIA PE=2 SV=2 PF00060//PF10613 Ligand-gated ion channel//Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0035235//GO:0006811 signal transduction//synaptic transmission//ionotropic glutamate receptor signaling pathway//ion transport GO:0004970//GO:0005234 ionotropic glutamate receptor activity//extracellular-glutamate-gated ion channel activity GO:0030288//GO:0005886//GO:0016021//GO:0016020//GO:0030054//GO:0045211 outer membrane-bounded periplasmic space//plasma membrane//integral component of membrane//membrane//cell junction//postsynaptic membrane KOG1054 Glutamate-gated AMPA-type ion channel receptor subunit GluR2 and related subunits Cluster-8309.51814 BF_2 342.46 5.00 3152 642937952 XP_970081.3 435 7.4e-40 PREDICTED: uncharacterized protein LOC658612 isoform X2 [Tribolium castaneum]>gi|270015689|gb|EFA12137.1| hypothetical protein TcasGA2_TC002283 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51816 BF_2 11.01 0.98 755 752871781 XP_011253103.1 673 4.5e-68 PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus]>gi|752871783|ref|XP_011253104.1| PREDICTED: leucine-rich repeat-containing protein 58 isoform X1 [Camponotus floridanus] 826438850 XM_012674433.1 127 8.32476e-58 PREDICTED: Monomorium pharaonis uncharacterized LOC105833032 (LOC105833032), mRNA -- -- -- -- Q3ZCU0 217 1.4e-16 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.51821 BF_2 24.04 0.67 1785 546685752 ERL95207.1 1000 1.3e-105 hypothetical protein D910_12474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5XIJ8 413 6.1e-39 Coiled-coil domain-containing protein 65 OS=Rattus norvegicus GN=Ccdc65 PE=2 SV=1 PF02927 N-terminal ig-like domain of cellulase GO:0005982//GO:0005985//GO:0005975 starch metabolic process//sucrose metabolic process//carbohydrate metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.51824 BF_2 63.79 1.72 1840 91081173 XP_975583.1 899 6.8e-94 PREDICTED: mitochondrial 2-oxodicarboxylate carrier [Tribolium castaneum]>gi|270006043|gb|EFA02491.1| hypothetical protein TcasGA2_TC008186 [Tribolium castaneum] -- -- -- -- -- K15110 SLC25A21, ODC solute carrier family 25 (mitochondrial 2-oxodicarboxylate transporter), member 21 http://www.genome.jp/dbget-bin/www_bget?ko:K15110 A0JN87 673 4.5e-69 Mitochondrial 2-oxodicarboxylate carrier OS=Bos taurus GN=SLC25A21 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0754 Mitochondrial oxodicarboxylate carrier protein Cluster-8309.51825 BF_2 9.00 0.49 1052 817089178 XP_012267440.1 531 1.8e-51 PREDICTED: PDZ and LIM domain protein Zasp isoform X1 [Athalia rosae] -- -- -- -- -- -- -- -- -- A1ZA47 493 1.9e-48 PDZ and LIM domain protein Zasp OS=Drosophila melanogaster GN=Zasp52 PE=1 SV=2 PF13180//PF00595 PDZ domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG1703 Adaptor protein Enigma and related PDZ-LIM proteins Cluster-8309.51827 BF_2 120.45 4.67 1365 189241705 XP_967022.2 933 5.8e-98 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 B9F676 733 3.7e-76 Probable glucan 1,3-alpha-glucosidase OS=Oryza sativa subsp. japonica GN=Os03g0216600 PE=3 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.51830 BF_2 323.88 3.42 4251 642932427 XP_008197107.1 4443 0.0e+00 PREDICTED: uncharacterized protein KIAA0195 isoform X2 [Tribolium castaneum]>gi|270012352|gb|EFA08800.1| hypothetical protein TcasGA2_TC006494 [Tribolium castaneum] 391330831 XM_003739808.1 45 1.86428e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q12767 1284 1.5e-139 Uncharacterized protein KIAA0195 OS=Homo sapiens GN=KIAA0195 PE=1 SV=1 PF01844//PF08053//PF00122 HNH endonuclease//Tryptophanase operon leader peptide//E1-E2 ATPase GO:0031554//GO:0031556 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome GO:0046872//GO:0000166//GO:0004519//GO:0003676 metal ion binding//nucleotide binding//endonuclease activity//nucleic acid binding -- -- KOG4383 Uncharacterized conserved protein Cluster-8309.51832 BF_2 114.41 1.10 4637 478261315 ENN80731.1 2577 4.6e-288 hypothetical protein YQE_02839, partial [Dendroctonus ponderosae] 391330831 XM_003739808.1 45 2.035e-11 PREDICTED: Metaseiulus occidentalis uncharacterized LOC100899402 (LOC100899402), mRNA -- -- -- -- Q7TSH8 909 4.9e-96 Uncharacterized protein KIAA0195 OS=Mus musculus GN=Kiaa0195 PE=2 SV=1 PF01844//PF00122 HNH endonuclease//E1-E2 ATPase -- -- GO:0003676//GO:0000166//GO:0004519//GO:0046872 nucleic acid binding//nucleotide binding//endonuclease activity//metal ion binding -- -- KOG4383 Uncharacterized conserved protein Cluster-8309.51837 BF_2 29.43 0.73 1983 642925139 XP_001813550.2 389 1.0e-34 PREDICTED: zinc finger protein 569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P17789 208 4.0e-15 Protein tramtrack, beta isoform OS=Drosophila melanogaster GN=ttk PE=1 SV=2 PF00651//PF13912//PF02892//PF00096//PF13465 BTB/POZ domain//C2H2-type zinc finger//BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0003677//GO:0046872//GO:0005515 DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.51838 BF_2 121.06 3.31 1817 91092536 XP_967769.1 1936 3.8e-214 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 441 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1235 3.0e-134 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004672//GO:0004674//GO:0005524 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.51840 BF_2 3.00 0.85 435 91094065 XP_969875.1 309 4.1e-26 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016181|gb|EFA12629.1| cytochrome P450 6BR1 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 172 1.3e-11 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00067//PF15681 Cytochrome P450//Lymphocyte activation family X GO:0055114//GO:0051249//GO:0006955 oxidation-reduction process//regulation of lymphocyte activation//immune response GO:0016491//GO:0016705//GO:0020037//GO:0005506//GO:0005488 oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding//binding -- -- -- -- Cluster-8309.51841 BF_2 38.69 2.53 927 73921480 AAZ94270.1 468 3.2e-44 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V773 309 3.7e-27 Probable cytochrome P450 6a20 OS=Drosophila melanogaster GN=Cyp6a20 PE=2 SV=2 PF00336//PF00067//PF15681 DNA polymerase (viral) C-terminal domain//Cytochrome P450//Lymphocyte activation family X GO:0006955//GO:0051249//GO:0051252//GO:0055114 immune response//regulation of lymphocyte activation//regulation of RNA metabolic process//oxidation-reduction process GO:0005506//GO:0020037//GO:0004523//GO:0016705 iron ion binding//heme binding//RNA-DNA hybrid ribonuclease activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.51842 BF_2 55.00 1.89 1506 73921480 AAZ94270.1 1025 1.4e-108 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U9 842 9.3e-89 Probable cytochrome P450 6a13 OS=Drosophila melanogaster GN=Cyp6a13 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0016491//GO:0005506//GO:0016705//GO:0005488 heme binding//oxidoreductase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//binding -- -- -- -- Cluster-8309.51843 BF_2 154.00 4.50 1718 642912066 XP_008200783.1 677 3.5e-68 PREDICTED: cytochrome P450 monooxygenase isoform X1 [Tribolium castaneum]>gi|270002891|gb|EEZ99338.1| cytochrome P450 6BQ13 [Tribolium castaneum] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 589 2.3e-59 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.51846 BF_2 734.68 7.87 4194 642940163 XP_972562.2 2969 0.0e+00 PREDICTED: integral membrane protein GPR155 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R9A7 897 1.1e-94 Integral membrane protein GPR155 OS=Pongo abelii GN=GPR155 PE=2 SV=1 PF03547//PF00610 Membrane transport protein//Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GO:0035556//GO:0055085 intracellular signal transduction//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.51847 BF_2 1022.65 6.57 6801 546675629 ERL86779.1 7377 0.0e+00 hypothetical protein D910_04185 [Dendroctonus ponderosae] 705688754 XM_010123154.1 36 3.01198e-06 PREDICTED: Chlamydotis macqueenii activating signal cointegrator 1 complex subunit 3 (ASCC3), partial mRNA K18663 ASCC3 activating signal cointegrator complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18663 F1NTD6 3950 0.0e+00 Activating signal cointegrator 1 complex subunit 3 OS=Gallus gallus GN=ascc3 PE=3 SV=2 PF00270//PF00437//PF02562//PF04851//PF00098//PF00580//PF00176 DEAD/DEAH box helicase//Type II/IV secretion system protein//PhoH-like protein//Type III restriction enzyme, res subunit//Zinc knuckle//UvrD/REP helicase N-terminal domain//SNF2 family N-terminal domain GO:0006810 transport GO:0003676//GO:0003677//GO:0016787//GO:0005524//GO:0008270 nucleic acid binding//DNA binding//hydrolase activity//ATP binding//zinc ion binding -- -- KOG0952 DNA/RNA helicase MER3/SLH1, DEAD-box superfamily Cluster-8309.51848 BF_2 42.26 0.66 2974 642938535 XP_008199831.1 737 6.7e-75 PREDICTED: uncharacterized protein LOC103314771 [Tribolium castaneum] 642938534 XM_008201609.1 67 7.65652e-24 PREDICTED: Tribolium castaneum uncharacterized LOC103314771 (LOC103314771), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51851 BF_2 549.11 5.48 4477 642926793 XP_008195018.1 4231 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] 241594866 XM_002404360.1 87 8.82108e-35 Ixodes scapularis ankyrin repeat containing protein, mRNA -- -- -- -- Q810B6 2521 5.6e-283 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF00651//PF00023//PF01363//PF13606//PF01155//PF01068 BTB/POZ domain//Ankyrin repeat//FYVE zinc finger//Ankyrin repeat//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//ATP dependent DNA ligase domain GO:0006260//GO:0006310//GO:0006281//GO:0006464 DNA replication//DNA recombination//DNA repair//cellular protein modification process GO:0046872//GO:0003910//GO:0005515//GO:0016151//GO:0005524 metal ion binding//DNA ligase (ATP) activity//protein binding//nickel cation binding//ATP binding -- -- KOG0504 FOG: Ankyrin repeat Cluster-8309.51855 BF_2 5589.91 96.55 2709 315570560 ADU33284.1 2397 2.0e-267 glycoside hydrolase family protein 48 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- P50899 1926 3.4e-214 Exoglucanase B OS=Cellulomonas fimi (strain ATCC 484 / DSM 20113 / JCM 1341 / NBRC 15513 / NCIMB 8980 / NCTC 7547) GN=cbhB PE=1 SV=1 PF02011 Glycosyl hydrolase family 48 GO:0005982//GO:0005985//GO:0030245//GO:0005975 starch metabolic process//sucrose metabolic process//cellulose catabolic process//carbohydrate metabolic process GO:0008810//GO:0004553 cellulase activity//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.51858 BF_2 154.17 0.43 15365 642914247 XP_008201606.1 18780 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 951 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10506 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF00028//PF07645//PF00008 Cadherin domain//Calcium-binding EGF domain//EGF-like domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.51861 BF_2 1.00 3.23 267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51865 BF_2 5.00 7.96 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51867 BF_2 7.00 2.00 433 307190171 EFN74294.1 232 3.5e-17 120.7 kDa protein in NOF-FB transposable element, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51870 BF_2 5.00 0.63 618 270012872 EFA09320.1 252 2.4e-19 hypothetical protein TcasGA2_TC001646 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NBX4 154 2.3e-09 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51872 BF_2 402.49 2.96 5983 642920211 XP_008192250.1 2586 5.3e-289 PREDICTED: LOW QUALITY PROTEIN: probable ATP-dependent RNA helicase DDX11 [Tribolium castaneum] 721631354 XM_003567893.2 45 2.63033e-11 PREDICTED: Brachypodium distachyon mannose-6-phosphate isomerase 1 (LOC100835530), mRNA K11273 DDX11, CHL1, CTF1 chromosome transmission fidelity protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11273 Q92771 1452 6.8e-159 Putative ATP-dependent RNA helicase DDX12 OS=Homo sapiens GN=DDX12P PE=5 SV=3 PF00170//PF13307//PF01238//PF02944//PF06733//PF08471//PF04851//PF02562//PF01416 bZIP transcription factor//Helicase C-terminal domain//Phosphomannose isomerase type I//BESS motif//DEAD_2//Class II vitamin B12-dependent ribonucleotide reductase//Type III restriction enzyme, res subunit//PhoH-like protein//tRNA pseudouridine synthase GO:0006000//GO:0005975//GO:0001522//GO:0055114//GO:0006355//GO:0006139//GO:0006013//GO:0009451//GO:0006206//GO:0006144//GO:0009186 fructose metabolic process//carbohydrate metabolic process//pseudouridine synthesis//oxidation-reduction process//regulation of transcription, DNA-templated//nucleobase-containing compound metabolic process//mannose metabolic process//RNA modification//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0016818//GO:0050897//GO:0003700//GO:0004003//GO:0009982//GO:0043565//GO:0008270//GO:0004476//GO:0016787//GO:0005524//GO:0003676//GO:0004748//GO:0008026//GO:0003677//GO:0003723 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//cobalt ion binding//transcription factor activity, sequence-specific DNA binding//ATP-dependent DNA helicase activity//pseudouridine synthase activity//sequence-specific DNA binding//zinc ion binding//mannose-6-phosphate isomerase activity//hydrolase activity//ATP binding//nucleic acid binding//ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//ATP-dependent helicase activity//DNA binding//RNA binding GO:0005971//GO:0005667//GO:0005657 ribonucleoside-diphosphate reductase complex//transcription factor complex//replication fork KOG1133 Helicase of the DEAD superfamily Cluster-8309.51873 BF_2 44.92 0.41 4871 478253139 ENN73510.1 1950 2.4e-215 hypothetical protein YQE_09761, partial [Dendroctonus ponderosae]>gi|546678891|gb|ERL89429.1| hypothetical protein D910_06796 [Dendroctonus ponderosae] -- -- -- -- -- K16309 MASTL, GW serine/threonine-protein kinase greatwall http://www.genome.jp/dbget-bin/www_bget?ko:K16309 Q9VM60 1077 1.7e-115 Mini-chromosome maintenance complex-binding protein OS=Drosophila melanogaster GN=CG3430 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG2545 Conserved membrane protein Cluster-8309.51874 BF_2 41.08 0.39 4682 478253139 ENN73510.1 1950 2.3e-215 hypothetical protein YQE_09761, partial [Dendroctonus ponderosae]>gi|546678891|gb|ERL89429.1| hypothetical protein D910_06796 [Dendroctonus ponderosae] -- -- -- -- -- K16309 MASTL, GW serine/threonine-protein kinase greatwall http://www.genome.jp/dbget-bin/www_bget?ko:K16309 Q9VM60 1077 1.6e-115 Mini-chromosome maintenance complex-binding protein OS=Drosophila melanogaster GN=CG3430 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG2545 Conserved membrane protein Cluster-8309.51877 BF_2 51.77 0.37 6080 91090894 XP_973482.1 1323 1.5e-142 PREDICTED: ileal sodium/bile acid cotransporter isoform X1 [Tribolium castaneum]>gi|270013229|gb|EFA09677.1| hypothetical protein TcasGA2_TC011805 [Tribolium castaneum] -- -- -- -- -- K14343 SLC10A3_5 solute carrier family 10 (sodium/bile acid cotransporter), member 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14343 P09131 356 8.5e-32 P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1 PF04785//PF01758 Rhabdovirus matrix protein M2//Sodium Bile acid symporter family GO:0016032 viral process -- -- GO:0016020//GO:0019031 membrane//viral envelope KOG2718 Na+-bile acid cotransporter Cluster-8309.51878 BF_2 138.76 1.20 5130 642935997 XP_008198262.1 1304 2.1e-140 PREDICTED: ileal sodium/bile acid cotransporter isoform X2 [Tribolium castaneum] -- -- -- -- -- K14343 SLC10A3_5 solute carrier family 10 (sodium/bile acid cotransporter), member 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14343 P09131 356 7.2e-32 P3 protein OS=Homo sapiens GN=SLC10A3 PE=2 SV=1 PF04785//PF01758 Rhabdovirus matrix protein M2//Sodium Bile acid symporter family GO:0016032 viral process -- -- GO:0016020//GO:0019031 membrane//viral envelope KOG2718 Na+-bile acid cotransporter Cluster-8309.51883 BF_2 7.00 1.31 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51885 BF_2 476.95 5.45 3945 642912351 XP_008199606.1 871 2.6e-90 PREDICTED: formin-binding protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQ03 139 8.0e-07 Formin-binding protein 4 OS=Mus musculus GN=Fnbp4 PE=1 SV=2 PF00397//PF06632 WW domain//DNA double-strand break repair and V(D)J recombination protein XRCC4 GO:0006302//GO:0006310 double-strand break repair//DNA recombination GO:0005515//GO:0003677 protein binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.51886 BF_2 91.62 0.98 4200 270002668 EEZ99115.1 599 9.5e-59 hypothetical protein TcasGA2_TC005008 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQ03 139 8.6e-07 Formin-binding protein 4 OS=Mus musculus GN=Fnbp4 PE=1 SV=2 PF00397//PF07267//PF00963 WW domain//Nucleopolyhedrovirus capsid protein P87//Cohesin domain GO:0000272 polysaccharide catabolic process GO:0030246//GO:0005515 carbohydrate binding//protein binding GO:0019028 viral capsid -- -- Cluster-8309.51887 BF_2 290.42 3.23 4053 642912351 XP_008199606.1 871 2.6e-90 PREDICTED: formin-binding protein 4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZQ03 139 8.3e-07 Formin-binding protein 4 OS=Mus musculus GN=Fnbp4 PE=1 SV=2 PF00397//PF01213//PF06632 WW domain//Adenylate cyclase associated (CAP) N terminal//DNA double-strand break repair and V(D)J recombination protein XRCC4 GO:0007010//GO:0006302//GO:0006310 cytoskeleton organization//double-strand break repair//DNA recombination GO:0003779//GO:0005515//GO:0003677 actin binding//protein binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.51889 BF_2 131.36 1.56 3816 478257263 ENN77426.1 487 8.4e-46 hypothetical protein YQE_06251, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.51890 BF_2 106.92 1.27 3817 478257263 ENN77426.1 487 8.4e-46 hypothetical protein YQE_06251, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8309.51891 BF_2 25.72 0.54 2284 546683815 ERL93568.1 222 2.7e-15 hypothetical protein D910_10856 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51892 BF_2 264.36 9.64 1434 91091890 XP_970295.1 1595 1.0e-174 PREDICTED: mitotic checkpoint protein BUB3 [Tribolium castaneum]>gi|270001257|gb|EEZ97704.1| budding uninhibited by benzimidazoles 3 [Tribolium castaneum] 642937433 XM_965202.2 331 6.38473e-171 PREDICTED: Tribolium castaneum budding uninhibited by benzimidazoles 3 (LOC658849), mRNA K02180 BUB3 cell cycle arrest protein BUB3 http://www.genome.jp/dbget-bin/www_bget?ko:K02180 Q1JQB2 1172 4.8e-127 Mitotic checkpoint protein BUB3 OS=Bos taurus GN=BUB3 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1036 Mitotic spindle checkpoint protein BUB3, WD repeat superfamily Cluster-8309.51893 BF_2 186.82 5.05 1835 270000732 EEZ97179.1 795 7.8e-82 hypothetical protein TcasGA2_TC004366 [Tribolium castaneum] -- -- -- -- -- K13203 ZFR zinc finger RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13203 Q5REX3 466 4.5e-45 Zinc finger RNA-binding protein OS=Pongo abelii GN=ZFR PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3792 Transcription factor NFAT, subunit NF90 Cluster-8309.51897 BF_2 444.34 17.96 1322 478259707 ENN79551.1 456 1.1e-42 hypothetical protein YQE_04013, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R508 154 4.9e-09 Protocadherin Fat 3 OS=Rattus norvegicus GN=Fat3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51898 BF_2 8.00 1.42 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51900 BF_2 381.60 10.37 1827 741829513 AJA91072.1 1636 2.3e-179 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 1092 1.2e-117 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.51901 BF_2 1541.71 19.00 3682 189235428 XP_001812612.1 4557 0.0e+00 PREDICTED: importin-4-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TEX9 1523 2.5e-167 Importin-4 OS=Homo sapiens GN=IPO4 PE=1 SV=2 PF03810//PF02985//PF07836//PF00514 Importin-beta N-terminal domain//HEAT repeat//DmpG-like communication domain//Armadillo/beta-catenin-like repeat GO:0019439//GO:0006886 aromatic compound catabolic process//intracellular protein transport GO:0005515//GO:0016833//GO:0008536 protein binding//oxo-acid-lyase activity//Ran GTPase binding -- -- KOG2171 Karyopherin (importin) beta 3 Cluster-8309.51902 BF_2 133.71 0.62 9314 270006108 EFA02556.1 1457 6.8e-158 hypothetical protein TcasGA2_TC008263 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 436 6.9e-41 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 PF08916 Phenylalanine zipper GO:0007165//GO:0035556 signal transduction//intracellular signal transduction GO:0004871 signal transducer activity -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.51903 BF_2 139.00 2.42 2685 91083987 XP_975212.1 1084 3.5e-115 PREDICTED: protein asteroid [Tribolium castaneum]>gi|270007987|gb|EFA04435.1| hypothetical protein TcasGA2_TC014736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VPW1 478 2.7e-46 Protein asteroid OS=Drosophila melanogaster GN=ast PE=2 SV=1 PF00752 XPG N-terminal domain GO:0006281//GO:0090304 DNA repair//nucleic acid metabolic process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.51905 BF_2 59.34 0.44 5904 641682104 XP_008189718.1 666 2.3e-66 PREDICTED: uncharacterized protein LOC100570869 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q96DM1 150 6.4e-08 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF02609 Exonuclease VII small subunit GO:0006308 DNA catabolic process GO:0008855 exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex -- -- Cluster-8309.51907 BF_2 81.65 0.85 4303 189235679 XP_971393.2 226 1.7e-15 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51911 BF_2 7449.62 692.76 737 478256984 ENN77148.1 167 2.1e-09 hypothetical protein YQE_06287, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01783 Ribosomal L32p protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit -- -- Cluster-8309.51914 BF_2 85.83 1.40 2858 642915391 XP_008190597.1 403 3.5e-36 PREDICTED: cytochrome c oxidase subunit 6B2 isoform X1 [Tribolium castaneum] 642915392 XM_969527.2 84 2.60789e-33 PREDICTED: Tribolium castaneum cytochrome c oxidase subunit 6B2 (LOC663486), transcript variant X2, mRNA K02267 COX6B cytochrome c oxidase subunit 6b http://www.genome.jp/dbget-bin/www_bget?ko:K02267 P14854 264 1.9e-21 Cytochrome c oxidase subunit 6B1 OS=Homo sapiens GN=COX6B1 PE=1 SV=2 PF07393//PF02297 Exocyst complex component Sec10//Cytochrome oxidase c subunit VIb GO:0015992//GO:0006887//GO:0048278//GO:0006123 proton transport//exocytosis//vesicle docking//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0005737//GO:0005739//GO:0045277 cytoplasm//mitochondrion//respiratory chain complex IV KOG3057 Cytochrome c oxidase, subunit VIb/COX12 Cluster-8309.51915 BF_2 2473.85 122.49 1132 642912083 XP_008200795.1 819 7.9e-85 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q27972 178 6.9e-12 Chondroadherin OS=Bos taurus GN=CHAD PE=1 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.51918 BF_2 202.35 1.08 8108 642919609 XP_008191938.1 1817 1.1e-199 PREDICTED: AT-rich interactive domain-containing protein 2 isoform X2 [Tribolium castaneum] 642919611 XM_008193717.1 100 9.50981e-42 PREDICTED: Tribolium castaneum AT-rich interactive domain-containing protein 2 (LOC664298), transcript variant X4, mRNA K11765 ARID2 AT-rich interactive domain-containing protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11765 Q68CP9 539 6.8e-53 AT-rich interactive domain-containing protein 2 OS=Homo sapiens GN=ARID2 PE=1 SV=2 PF02257//PF01388//PF12031 RFX DNA-binding domain//ARID/BRIGHT DNA binding domain//Domain of unknown function (DUF3518) GO:0006355//GO:0006338 regulation of transcription, DNA-templated//chromatin remodeling GO:0003677 DNA binding GO:0090544 BAF-type complex KOG2312 Predicted transcriptional regulator, contains ARID domain Cluster-8309.51919 BF_2 14.00 2.51 520 297300831 XP_002805672.1 711 1.2e-72 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret-like [Macaca mulatta] 336042955 JF276429.1 520 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 541 2.6e-54 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5192 BF_2 35.57 0.71 2389 478263509 ENN81862.1 482 2.0e-45 hypothetical protein YQE_01754, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF04111//PF07851//PF02601 Outer membrane protein (OmpH-like)//Autophagy protein Apg6//TMPIT-like protein//Exonuclease VII, large subunit GO:0006308//GO:0006914 DNA catabolic process//autophagy GO:0051082//GO:0008855 unfolded protein binding//exodeoxyribonuclease VII activity GO:0016021//GO:0009318 integral component of membrane//exodeoxyribonuclease VII complex -- -- Cluster-8309.51920 BF_2 97.81 3.92 1332 642932849 XP_008197011.1 848 4.0e-88 PREDICTED: NAD kinase-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K00858 ppnK, NADK NAD+ kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00858 P58058 580 2.0e-58 NAD kinase OS=Mus musculus GN=Nadk PE=1 SV=2 PF00781//PF01513 Diacylglycerol kinase catalytic domain//ATP-NAD kinase GO:0006769//GO:0046497//GO:0008152//GO:0006741 nicotinamide metabolic process//nicotinate nucleotide metabolic process//metabolic process//NADP biosynthetic process GO:0003951//GO:0016301 NAD+ kinase activity//kinase activity -- -- KOG2178 Predicted sugar kinase Cluster-8309.51921 BF_2 245.05 1.99 5433 546683205 ERL93045.1 2710 2.0e-303 hypothetical protein D910_10347 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96JG6 1322 7.4e-144 Syndetin OS=Homo sapiens GN=CCDC132 PE=1 SV=3 PF08718//PF04189//PF12422//PF04048 Glycolipid transfer protein (GLTP)//Gcd10p family//Condensin II non structural maintenance of chromosomes subunit//Sec8 exocyst complex component specific domain GO:0006904//GO:0030488//GO:0046836//GO:0015031 vesicle docking involved in exocytosis//tRNA methylation//glycolipid transport//protein transport GO:0017089//GO:0051861 glycolipid transporter activity//glycolipid binding GO:0005634//GO:0000145//GO:0031515//GO:0005737 nucleus//exocyst//tRNA (m1A) methyltransferase complex//cytoplasm KOG2939 Uncharacterized conserved protein Cluster-8309.51922 BF_2 58.57 0.47 5527 546683205 ERL93045.1 2710 2.1e-303 hypothetical protein D910_10347 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96JG6 1322 7.5e-144 Syndetin OS=Homo sapiens GN=CCDC132 PE=1 SV=3 PF12422//PF04048//PF04189//PF08718 Condensin II non structural maintenance of chromosomes subunit//Sec8 exocyst complex component specific domain//Gcd10p family//Glycolipid transfer protein (GLTP) GO:0046836//GO:0006904//GO:0030488//GO:0015031 glycolipid transport//vesicle docking involved in exocytosis//tRNA methylation//protein transport GO:0017089//GO:0051861 glycolipid transporter activity//glycolipid binding GO:0005634//GO:0000145//GO:0005737//GO:0031515 nucleus//exocyst//cytoplasm//tRNA (m1A) methyltransferase complex KOG2939 Uncharacterized conserved protein Cluster-8309.51923 BF_2 538.00 249.48 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51924 BF_2 72.47 1.87 1905 571330962 AHF27413.1 1329 9.7e-144 putative sugar transporter 1 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- A5LGM7 437 1.1e-41 Facilitated trehalose transporter Tret1 OS=Polypedilum vanderplanki GN=Tret1 PE=1 SV=1 PF00083//PF07690//PF03137 Sugar (and other) transporter//Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.51925 BF_2 145.69 3.60 1980 642918258 XP_008191434.1 1452 5.5e-158 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918260|ref|XP_008191435.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918262|ref|XP_008191436.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q1HG43 346 4.0e-31 Dual oxidase maturation factor 1 OS=Homo sapiens GN=DUOXA1 PE=1 SV=1 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG3921 Uncharacterized conserved protein Cluster-8309.51927 BF_2 475.15 8.08 2747 642935463 XP_008198020.1 2980 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 820850190 XM_012487292.1 50 1.99231e-14 PREDICTED: Apis florea constitutive coactivator of PPAR-gamma-like protein 1 homolog (LOC100866531), mRNA -- -- -- -- Q6A0A9 755 2.1e-78 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51928 BF_2 912.20 3.90 10083 642935465 XP_008198021.1 3334 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X2 [Tribolium castaneum] 642935470 XM_967302.3 113 7.02389e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- Q6A0A9 763 9.0e-79 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 PF07690//PF00083//PF01328 Major Facilitator Superfamily//Sugar (and other) transporter//Peroxidase, family 2 GO:0006804//GO:0006979//GO:0055085 obsolete peroxidase reaction//response to oxidative stress//transmembrane transport GO:0004601//GO:0022857 peroxidase activity//transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.51930 BF_2 5.00 0.99 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51933 BF_2 32.12 0.51 2903 111182472 ABH07674.1 894 4.1e-93 gut-specific chitinase [Apriona germari]>gi|111182474|gb|ABH07675.1| gut-specific chitinase [Apriona germari] 111182471 DQ837584.1 326 7.87229e-168 Apriona germari gut-specific chitinase mRNA, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q13231 434 3.7e-41 Chitotriosidase-1 OS=Homo sapiens GN=CHIT1 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0006032//GO:0005975//GO:0016998 chitin catabolic process//carbohydrate metabolic process//cell wall macromolecule catabolic process GO:0043169//GO:0004553//GO:0004568 cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds//chitinase activity -- -- -- -- Cluster-8309.51934 BF_2 5522.29 232.68 1280 111182472 ABH07674.1 1551 1.2e-169 gut-specific chitinase [Apriona germari]>gi|111182474|gb|ABH07675.1| gut-specific chitinase [Apriona germari] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q95M17 706 4.7e-73 Acidic mammalian chitinase OS=Bos taurus GN=CHIA PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0006032//GO:0016998//GO:0005975 chitin catabolic process//cell wall macromolecule catabolic process//carbohydrate metabolic process GO:0004553//GO:0043169//GO:0004568 hydrolase activity, hydrolyzing O-glycosyl compounds//cation binding//chitinase activity -- -- -- -- Cluster-8309.51936 BF_2 280.90 7.99 1757 642914399 XP_974973.2 1511 7.0e-165 PREDICTED: uncharacterized protein LOC663847 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NUJ7 199 3.9e-14 PI-PLC X domain-containing protein 1 OS=Homo sapiens GN=PLCXD1 PE=2 SV=1 PF03490 Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.51940 BF_2 238.75 2.29 4644 91082383 XP_968748.1 3454 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] 462340820 APGK01036268.1 160 2.40479e-75 Dendroctonus ponderosae Seq01036278, whole genome shotgun sequence K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 2490 2.3e-279 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00004//PF02714//PF01926//PF13304//PF00664//PF00931//PF03193//PF00005//PF02367//PF06414//PF01637 ATPase family associated with various cellular activities (AAA)//Calcium-dependent channel, 7TM region, putative phosphate//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//NB-ARC domain//Protein of unknown function, DUF258//ABC transporter//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//Archaeal ATPase GO:0002949//GO:0055085//GO:0006810 tRNA threonylcarbamoyladenosine modification//transmembrane transport//transport GO:0016301//GO:0016887//GO:0005525//GO:0017111//GO:0042626//GO:0005524//GO:0003924//GO:0043531 kinase activity//ATPase activity//GTP binding//nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity//ADP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.51941 BF_2 6631.00 197.88 1689 748995280 AJE75662.1 1370 1.5e-148 putative glycosyl hydrolase [Chrysomela lapponica] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1088 3.1e-117 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.51943 BF_2 113.39 4.61 1315 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00014//PF06929 Kunitz/Bovine pancreatic trypsin inhibitor domain//Rotavirus VP3 protein GO:0016032 viral process GO:0004867//GO:0005525 serine-type endopeptidase inhibitor activity//GTP binding GO:0019013 viral nucleocapsid -- -- Cluster-8309.51944 BF_2 36.36 0.95 1894 642915648 XP_008190695.1 1161 2.9e-124 PREDICTED: uncharacterized protein LOC103312267 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DCD5 235 2.8e-18 Tight junction-associated protein 1 OS=Mus musculus GN=Tjap1 PE=1 SV=1 PF01890//PF05791//PF07989 Cobalamin synthesis G C-terminus//Bacillus haemolytic enterotoxin (HBL)//Centrosomin N-terminal motif 1 GO:0009236//GO:0009405 cobalamin biosynthetic process//pathogenesis -- -- GO:0016020//GO:0005815 membrane//microtubule organizing center -- -- Cluster-8309.51946 BF_2 4.00 0.53 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51948 BF_2 20.00 0.53 1851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51949 BF_2 83.60 0.54 6786 642910887 XP_008193450.1 6367 0.0e+00 PREDICTED: calcium-dependent secretion activator isoform X5 [Tribolium castaneum] 642910886 XM_008195228.1 1696 0 PREDICTED: Tribolium castaneum calcium-dependent secretion activator (LOC660877), transcript variant X6, mRNA -- -- -- -- Q9NHE5 4160 0.0e+00 Calcium-dependent secretion activator OS=Drosophila melanogaster GN=Caps PE=1 SV=3 PF11615 Protein of unknown function (DUF3249) GO:0000266 mitochondrial fission -- -- GO:0005739 mitochondrion KOG3543 Ca2+-dependent activator protein Cluster-8309.51951 BF_2 128.19 1.24 4602 91077854 XP_972003.1 1769 2.2e-194 PREDICTED: tetratricopeptide repeat protein 7B [Tribolium castaneum]>gi|270002262|gb|EEZ98709.1| hypothetical protein TcasGA2_TC001250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86TV6 697 1.9e-71 Tetratricopeptide repeat protein 7B OS=Homo sapiens GN=TTC7B PE=1 SV=3 PF13414//PF13176//PF13371//PF13181//PF13374//PF00515 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4162 Predicted calmodulin-binding protein Cluster-8309.51953 BF_2 367.28 3.86 4264 642930462 XP_008196413.1 2488 8.8e-278 PREDICTED: phosphofurin acidic cluster sorting protein 1 [Tribolium castaneum]>gi|270009398|gb|EFA05846.1| hypothetical protein TcasGA2_TC008635 [Tribolium castaneum] 558214452 XM_006108296.1 57 3.99102e-18 PREDICTED: Myotis lucifugus phosphofurin acidic cluster sorting protein 2 (PACS2), partial mRNA -- -- -- -- Q5ZKF4 633 4.5e-64 High mobility group protein 20A OS=Gallus gallus GN=HMG20A PE=2 SV=1 PF01496//PF04513//PF07851 V-type ATPase 116kDa subunit family//Baculovirus polyhedron envelope protein, PEP, C terminus//TMPIT-like protein GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0005198//GO:0015078 structural molecule activity//hydrogen ion transmembrane transporter activity GO:0019028//GO:0016021//GO:0019031//GO:0033179 viral capsid//integral component of membrane//viral envelope//proton-transporting V-type ATPase, V0 domain KOG0381 HMG box-containing protein Cluster-8309.51954 BF_2 46.29 0.56 3715 642934333 XP_008198606.1 2979 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X4 [Tribolium castaneum] 817086197 XM_012410395.1 89 5.64907e-36 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF01436//PF05524//PF05929//PF00097//PF14634//PF00643//PF13639//PF01580//PF02601//PF03358//PF01637//PF05149 NHL repeat//PEP-utilising enzyme, N-terminal//Phage capsid scaffolding protein (GPO) serine peptidase//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//B-box zinc finger//Ring finger domain//FtsK/SpoIIIE family//Exonuclease VII, large subunit//NADPH-dependent FMN reductase//Archaeal ATPase//Paraflagellar rod protein GO:0006308//GO:0019069//GO:0009401 DNA catabolic process//viral capsid assembly//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0046872//GO:0000166//GO:0008270//GO:0016491//GO:0005515//GO:0008855//GO:0003677//GO:0005516//GO:0005524 metal ion binding//nucleotide binding//zinc ion binding//oxidoreductase activity//protein binding//exodeoxyribonuclease VII activity//DNA binding//calmodulin binding//ATP binding GO:0005622//GO:0009318//GO:0031514 intracellular//exodeoxyribonuclease VII complex//motile cilium -- -- Cluster-8309.51956 BF_2 110.58 1.79 2875 91077428 XP_975436.1 1252 1.2e-134 PREDICTED: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A [Tribolium castaneum]>gi|270001628|gb|EEZ98075.1| hypothetical protein TcasGA2_TC000482 [Tribolium castaneum] -- -- -- -- -- K07442 TRM61, GCD14 tRNA (adenine57-N1/adenine58-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07442 A6H791 696 1.5e-71 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Bos taurus GN=TRMT61A PE=2 SV=1 PF01135//PF06816//PF03009//PF08704 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//NOTCH protein//Glycerophosphoryl diester phosphodiesterase family//tRNA methyltransferase complex GCD14 subunit GO:0008033//GO:0046500//GO:0030154//GO:0006479//GO:0009451//GO:0030488//GO:0006629//GO:0006464 tRNA processing//S-adenosylmethionine metabolic process//cell differentiation//protein methylation//RNA modification//tRNA methylation//lipid metabolic process//cellular protein modification process GO:0008081//GO:0004719//GO:0016429 phosphoric diester hydrolase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (adenine-N1-)-methyltransferase activity GO:0031515//GO:0016021 tRNA (m1A) methyltransferase complex//integral component of membrane KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14 Cluster-8309.51957 BF_2 58.00 0.46 5573 642937998 XP_008199164.1 2731 7.6e-306 PREDICTED: uncharacterized protein LOC103314558 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17Q32 131 9.6e-06 Enolase-phosphatase E1 OS=Aedes aegypti GN=AAEL000109 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51960 BF_2 316.87 3.59 3983 91082137 XP_966595.1 1646 3.5e-180 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 178 2.03089e-85 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1351 2.3e-147 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.51963 BF_2 761.72 6.01 5589 478254436 ENN74688.1 2866 0.0e+00 hypothetical protein YQE_08805, partial [Dendroctonus ponderosae] 697484427 XM_009675369.1 47 1.89866e-12 PREDICTED: Struthio camelus australis methionyl-tRNA synthetase (MARS), partial mRNA K01874 MARS, metG methionyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01874 Q6PF21 2041 3.2e-227 Methionine--tRNA ligase, cytoplasmic OS=Xenopus laevis GN=mars PE=2 SV=1 PF09334//PF00133//PF08264 tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Anticodon-binding domain of tRNA GO:0006418 tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding -- -- KOG1247 Methionyl-tRNA synthetase Cluster-8309.51967 BF_2 125.96 3.87 1647 91092400 XP_969218.1 1514 3.0e-165 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q60525 624 1.9e-63 Telomerase Cajal body protein 1 OS=Mesocricetus auratus GN=Wrap53 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG2919 Guanine nucleotide-binding protein Cluster-8309.51969 BF_2 790.00 14.38 2586 189241705 XP_967022.2 2234 1.5e-248 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] 194763848 XM_001964009.1 45 1.12865e-11 Drosophila ananassae GF21346 (Dana\GF21346), mRNA K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q9BE70 1439 9.5e-158 Neutral alpha-glucosidase C (Fragment) OS=Macaca fascicularis GN=GANC PE=2 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.5197 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51970 BF_2 2392.00 169.07 879 728418383 AIY68367.1 696 1.1e-70 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P19835 322 1.1e-28 Bile salt-activated lipase OS=Homo sapiens GN=CEL PE=1 SV=3 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.51971 BF_2 697.34 18.00 1908 728418241 AIY68362.1 1318 1.8e-142 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P12992 565 1.6e-56 Juvenile hormone esterase OS=Heliothis virescens PE=1 SV=2 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.51972 BF_2 5.67 0.32 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51973 BF_2 740.57 112.69 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51974 BF_2 90.76 3.99 1239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51979 BF_2 23.00 2.31 703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51981 BF_2 68.36 0.74 4168 642918835 XP_008191606.1 4250 0.0e+00 PREDICTED: DENN domain-containing protein 5B [Tribolium castaneum]>gi|270005624|gb|EFA02072.1| hypothetical protein TcasGA2_TC007707 [Tribolium castaneum] 571543384 XM_006559642.1 37 5.11739e-07 PREDICTED: Apis mellifera DENN domain-containing protein 5B-like (LOC412128), transcript variant X4, mRNA -- -- -- -- A2RSQ0 1907 8.3e-212 DENN domain-containing protein 5B OS=Mus musculus GN=Dennd5b PE=1 SV=2 PF01807//PF01477 CHC2 zinc finger//PLAT/LH2 domain GO:0006260//GO:0006269//GO:0006351 DNA replication//DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0008270//GO:0003677//GO:0003896//GO:0005515 zinc ion binding//DNA binding//DNA primase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork KOG2080 Uncharacterized conserved protein, contains DENN and RUN domains Cluster-8309.51985 BF_2 340.00 14.27 1284 768431187 XP_011556858.1 403 1.6e-36 PREDICTED: probable small nuclear ribonucleoprotein Sm D2 [Plutella xylostella] -- -- -- -- -- K11096 SNRPD2, SMD2 small nuclear ribonucleoprotein D2 http://www.genome.jp/dbget-bin/www_bget?ko:K11096 Q18786 385 7.8e-36 Probable small nuclear ribonucleoprotein Sm D2 OS=Caenorhabditis elegans GN=snr-4 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3459 Small nuclear ribonucleoprotein (snRNP) Sm core protein Cluster-8309.51986 BF_2 9.00 0.70 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.51987 BF_2 30.66 0.38 3645 642916726 XP_008192366.1 1461 9.2e-159 PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum]>gi|642916728|ref|XP_008192372.1| PREDICTED: collagen alpha-1(III) chain [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13830 137 1.3e-06 Ring-infected erythrocyte surface antigen OS=Plasmodium falciparum (isolate FC27 / Papua New Guinea) GN=RESA PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.51989 BF_2 269.43 5.91 2195 642919559 XP_008191923.1 2104 1.5e-233 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270005853|gb|EFA02301.1| hypothetical protein TcasGA2_TC007966 [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 782 1.2e-81 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.51991 BF_2 737.65 5.66 5737 642930100 XP_008196251.1 2972 0.0e+00 PREDICTED: putative epidermal cell surface receptor isoform X2 [Tribolium castaneum] 195454384 XM_002074181.1 39 5.45815e-08 Drosophila willistoni GK14524 (Dwil\GK14524), mRNA -- -- -- -- Q04164 1071 9.9e-115 Putative epidermal cell surface receptor OS=Drosophila melanogaster GN=sas PE=2 SV=2 PF00093//PF02556//PF00041 von Willebrand factor type C domain//Preprotein translocase subunit SecB//Fibronectin type III domain GO:0051262//GO:0015031 protein tetramerization//protein transport GO:0051082//GO:0005515 unfolded protein binding//protein binding -- -- -- -- Cluster-8309.51992 BF_2 4.26 0.40 728 642913613 XP_008201088.1 346 3.6e-30 PREDICTED: probable E3 ubiquitin-protein ligase HERC4 isoform X3 [Tribolium castaneum] -- -- -- -- -- K10615 HERC4 E3 ubiquitin-protein ligase HERC4 http://www.genome.jp/dbget-bin/www_bget?ko:K10615 Q6PAV2 207 1.9e-15 Probable E3 ubiquitin-protein ligase HERC4 OS=Mus musculus GN=Herc4 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0941 E3 ubiquitin protein ligase Cluster-8309.51994 BF_2 12649.00 606.23 1160 578359012 AHI15749.1 1717 6.0e-189 glycoside hydrolase family 5 subfamily 2 [Apriona japonica] 578359011 KJ186851.1 1160 0 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- P07103 624 1.4e-63 Endoglucanase Z OS=Dickeya dadantii (strain 3937) GN=celZ PE=1 SV=2 PF00150 Cellulase (glycosyl hydrolase family 5) GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.51995 BF_2 40.00 4.84 633 73921480 AAZ94270.1 597 2.4e-59 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V774 469 7.0e-46 Probable cytochrome P450 6a21 OS=Drosophila melanogaster GN=Cyp6a21 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0016491//GO:0046872//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//oxidoreductase activity//metal ion binding//heme binding -- -- -- -- Cluster-8309.51999 BF_2 447.00 16.92 1392 642928332 XP_008195538.1 1043 1.0e-110 PREDICTED: phospholipase A1 2 [Tribolium castaneum]>gi|270010341|gb|EFA06789.1| hypothetical protein TcasGA2_TC009725 [Tribolium castaneum] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 P54316 372 2.7e-34 Inactive pancreatic lipase-related protein 1 OS=Rattus norvegicus GN=Pnliprp1 PE=2 SV=1 PF01764//PF06821//PF07819 Lipase (class 3)//Serine hydrolase//PGAP1-like protein GO:0006505//GO:0006886//GO:0006629 GPI anchor metabolic process//intracellular protein transport//lipid metabolic process GO:0016787//GO:0016788//GO:0003824 hydrolase activity//hydrolase activity, acting on ester bonds//catalytic activity -- -- -- -- Cluster-8309.52000 BF_2 38.66 3.59 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52002 BF_2 15.66 0.58 1425 642913929 XP_008201218.1 1052 9.5e-112 PREDICTED: headcase protein [Tribolium castaneum] 642913928 XM_008202996.1 311 8.32297e-160 PREDICTED: Tribolium castaneum headcase protein (LOC664275), mRNA -- -- -- -- Q9N2M8 397 3.5e-37 Headcase protein OS=Drosophila melanogaster GN=hdc PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52004 BF_2 7.00 0.56 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52005 BF_2 25.06 0.79 1608 307185308 EFN71403.1 165 7.7e-09 hypothetical protein EAG_00286, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52006 BF_2 22.57 0.33 3113 808127092 XP_003397177.2 2065 7.2e-229 PREDICTED: protein kinase C-binding protein NELL1-like isoform X3 [Bombus terrestris] -- -- -- -- -- -- -- -- -- Q92832 892 3.1e-94 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 PF00093//PF07645//PF00008 von Willebrand factor type C domain//Calcium-binding EGF domain//EGF-like domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.52012 BF_2 290.28 2.65 4862 478252787 ENN73180.1 1403 6.5e-152 hypothetical protein YQE_10234, partial [Dendroctonus ponderosae]>gi|546682447|gb|ERL92380.1| hypothetical protein D910_09694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5I0E6 374 5.6e-34 RNA polymerase II subunit B1 CTD phosphatase Rpap2 OS=Rattus norvegicus GN=Rpap2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4780 Uncharacterized conserved protein Cluster-8309.52019 BF_2 65.84 0.89 3384 642920751 XP_008192546.1 1717 1.8e-188 PREDICTED: pre-mRNA cleavage complex 2 protein Pcf11 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 433 5.6e-41 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.52020 BF_2 147.33 0.68 9358 270006108 EFA02556.1 1470 2.1e-159 hypothetical protein TcasGA2_TC008263 [Tribolium castaneum] -- -- -- -- -- K14400 PCF11 pre-mRNA cleavage complex 2 protein Pcf11 http://www.genome.jp/dbget-bin/www_bget?ko:K14400 O94913 436 6.9e-41 Pre-mRNA cleavage complex 2 protein Pcf11 OS=Homo sapiens GN=PCF11 PE=1 SV=3 PF08916 Phenylalanine zipper GO:0035556//GO:0007165 intracellular signal transduction//signal transduction GO:0004871 signal transducer activity -- -- KOG2071 mRNA cleavage and polyadenylation factor I/II complex, subunit Pcf11 Cluster-8309.52021 BF_2 301.59 2.75 4873 91092158 XP_967537.1 1880 3.2e-207 PREDICTED: steroid receptor seven-up, isoforms B/C [Tribolium castaneum]>gi|270015100|gb|EFA11548.1| seven up [Tribolium castaneum] 145228045 EF372598.1 535 0 Callosobruchus maculatus COUP-TF/Svp nuclear hormone receptor (Svp) mRNA, complete cds K08547 NR2F1, TFCOUP1 COUP transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08547 P16375 1629 1.7e-179 Steroid receptor seven-up, isoforms B/C OS=Drosophila melanogaster GN=svp PE=2 SV=1 PF14554//PF00104//PF00105 VEGF heparin-binding domain//Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0030522//GO:0043401//GO:0006355//GO:0007165 intracellular receptor signaling pathway//steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction GO:0003700//GO:0008201//GO:0046872//GO:0043565//GO:0008270//GO:0003707//GO:0004879 transcription factor activity, sequence-specific DNA binding//heparin binding//metal ion binding//sequence-specific DNA binding//zinc ion binding//steroid hormone receptor activity//RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.52022 BF_2 12.36 0.60 1144 728418383 AIY68367.1 439 9.2e-41 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52023 BF_2 25.29 0.58 2098 642929101 XP_008195690.1 643 3.7e-64 PREDICTED: uncharacterized protein LOC103313645 [Tribolium castaneum]>gi|270010385|gb|EFA06833.1| hypothetical protein TcasGA2_TC009776 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52024 BF_2 15.45 1.36 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52025 BF_2 114.07 1.94 2745 642922702 XP_008193287.1 1703 6.0e-187 PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922704|ref|XP_008193288.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922706|ref|XP_008193289.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922708|ref|XP_008193290.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N695 750 7.9e-78 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF00474 Sodium:solute symporter family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.52026 BF_2 294.93 7.82 1865 270014347 EFA10795.1 637 1.7e-63 nuclear transport factor-2 [Tribolium castaneum] 572260423 XM_006608467.1 134 2.71314e-61 PREDICTED: Apis dorsata probable nuclear transport factor 2-like (LOC102679089), transcript variant X1, mRNA -- -- -- -- Q21735 314 1.9e-27 Probable nuclear transport factor 2 OS=Caenorhabditis elegans GN=ran-4 PE=3 SV=1 PF02136 Nuclear transport factor 2 (NTF2) domain GO:0006810 transport -- -- GO:0005622 intracellular KOG2104 Nuclear transport factor 2 Cluster-8309.52028 BF_2 74.03 2.56 1495 642937919 XP_008199130.1 1094 1.4e-116 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9I9B9 311 3.5e-27 Choline transporter-like protein 1 OS=Torpedo marmorata GN=slc44a1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1362 Choline transporter-like protein Cluster-8309.52029 BF_2 2700.31 27.56 4386 728417299 AIY68339.1 1269 2.0e-136 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 569 1.2e-56 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF03789//PF07859//PF00326 ELK domain//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0008236//GO:0003677//GO:0016787 serine-type peptidase activity//DNA binding//hydrolase activity -- -- -- -- Cluster-8309.52030 BF_2 375.40 14.20 1393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52031 BF_2 125.85 2.71 2228 642923071 XP_008193599.1 2072 7.9e-230 PREDICTED: matrix metalloproteinase 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q99PW6 812 4.1e-85 Matrix metalloproteinase-24 OS=Rattus norvegicus GN=Mmp24 PE=1 SV=1 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.52032 BF_2 65.29 0.83 3593 255958232 NP_001157646.1 2108 8.5e-234 matrix metalloproteinase 1 isoform 1 precursor [Tribolium castaneum]>gi|270008219|gb|EFA04667.1| matrix metalloproteinase 1 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q10739 816 2.3e-85 Matrix metalloproteinase-14 OS=Rattus norvegicus GN=Mmp14 PE=2 SV=2 PF01400//PF00413 Astacin (Peptidase family M12A)//Matrixin GO:0006508 proteolysis GO:0008270//GO:0005509//GO:0004222 zinc ion binding//calcium ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix -- -- Cluster-8309.52033 BF_2 98.94 2.01 2350 255958232 NP_001157646.1 2108 5.6e-234 matrix metalloproteinase 1 isoform 1 precursor [Tribolium castaneum]>gi|270008219|gb|EFA04667.1| matrix metalloproteinase 1 [Tribolium castaneum] -- -- -- -- -- K07763 MMP14 matrix metalloproteinase-14 (membrane-inserted) http://www.genome.jp/dbget-bin/www_bget?ko:K07763 Q10739 816 1.5e-85 Matrix metalloproteinase-14 OS=Rattus norvegicus GN=Mmp14 PE=2 SV=2 PF00413//PF01400 Matrixin//Astacin (Peptidase family M12A) GO:0006508 proteolysis GO:0005509//GO:0004222//GO:0008270 calcium ion binding//metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix -- -- Cluster-8309.52036 BF_2 5.00 1.30 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52037 BF_2 749.56 16.13 2231 546675654 ERL86804.1 1778 9.8e-196 hypothetical protein D910_04208 [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 Q8WY07 1135 1.5e-122 Cationic amino acid transporter 3 OS=Homo sapiens GN=SLC7A3 PE=1 SV=1 PF00324//PF15020//PF13520 Amino acid permease//Cation channel sperm-associated protein subunit delta//Amino acid permease GO:0006810//GO:0006865//GO:0055085//GO:0003333 transport//amino acid transport//transmembrane transport//amino acid transmembrane transport GO:0015171 amino acid transmembrane transporter activity GO:0016020//GO:0036128 membrane//CatSper complex KOG1286 Amino acid transporters Cluster-8309.52039 BF_2 14.90 0.48 1586 270000811 EEZ97258.1 1464 1.8e-159 hypothetical protein TcasGA2_TC011058 [Tribolium castaneum] -- -- -- -- -- K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P39054 1386 8.1e-152 Dynamin-2 OS=Mus musculus GN=Dnm2 PE=1 SV=2 PF01031//PF01926//PF01297//PF08477 Dynamin central region//50S ribosome-binding GTPase//Zinc-uptake complex component A periplasmic//Ras of Complex, Roc, domain of DAPkinase GO:0030001//GO:0007264 metal ion transport//small GTPase mediated signal transduction GO:0005525//GO:0046872 GTP binding//metal ion binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.52040 BF_2 561.54 8.64 3006 642937407 XP_008198823.1 2845 0.0e+00 PREDICTED: dynamin isoform X2 [Tribolium castaneum] -- -- -- -- -- K01528 DNM dynamin GTPase http://www.genome.jp/dbget-bin/www_bget?ko:K01528 P27619 2587 8.4e-291 Dynamin OS=Drosophila melanogaster GN=shi PE=1 SV=2 PF02212//PF01926//PF01031 Dynamin GTPase effector domain//50S ribosome-binding GTPase//Dynamin central region -- -- GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- KOG0446 Vacuolar sorting protein VPS1, dynamin, and related proteins Cluster-8309.52042 BF_2 1.58 0.36 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52045 BF_2 85.03 0.41 8997 642933690 XP_008197522.1 457 6.0e-42 PREDICTED: golgin subfamily A member 4-like [Tribolium castaneum]>gi|270012607|gb|EFA09055.1| hypothetical protein TcasGA2_TC006768 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 227 1.1e-16 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF02179//PF04048 BAG domain//Sec8 exocyst complex component specific domain GO:0015031//GO:0006904 protein transport//vesicle docking involved in exocytosis GO:0051087 chaperone binding GO:0000145 exocyst -- -- Cluster-8309.52047 BF_2 7.19 0.56 821 91080861 XP_971851.1 262 2.2e-20 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial [Tribolium castaneum]>gi|270006430|gb|EFA02878.1| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10 [Tribolium castaneum] -- -- -- -- -- K03954 NDUFA10 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K03954 P91929 161 4.7e-10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial OS=Drosophila melanogaster GN=ND42 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52051 BF_2 47.91 0.45 4708 478253546 ENN73864.1 968 1.7e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.47298e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 9.1e-82 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF01529 Peptidase family M50//DHHC palmitoyltransferase GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG2585 Uncharacterized conserved protein Cluster-8309.52052 BF_2 55.19 1.81 1566 642925505 XP_008194578.1 1185 4.0e-127 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 550 7.0e-55 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF06687 SUR7/PalI family -- -- -- -- GO:0005886 plasma membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.52053 BF_2 77.84 0.98 3602 478263518 ENN81868.1 427 7.2e-39 hypothetical protein YQE_01746, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q68EI3 201 4.7e-14 Cytosolic carboxypeptidase-like protein 5 OS=Danio rerio GN=agbl5 PE=2 SV=1 PF05656//PF06638 Protein of unknown function (DUF805)//Strabismus protein GO:0007275 multicellular organismal development -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.52055 BF_2 15.51 0.44 1754 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52057 BF_2 17.04 0.40 2067 332372486 AEE61385.1 1589 7.5e-174 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5LJP9 903 1.1e-95 Asparagine synthetase domain-containing protein CG17486 OS=Drosophila melanogaster GN=CG17486 PE=2 SV=2 PF00733 Asparagine synthase GO:0006531//GO:0006522//GO:0006529 aspartate metabolic process//alanine metabolic process//asparagine biosynthetic process GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG0573 Asparagine synthase Cluster-8309.5206 BF_2 17.00 0.43 1942 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52062 BF_2 17.18 0.36 2301 2660868 AAC48288.1 1073 5.7e-114 fast tropomyosin isoform [Homarus americanus] 151505278 EF672351.1 814 0 Scylla serrata tropomyosin mRNA, complete cds K10373 TPM1 tropomyosin 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10373 O44119 1117 1.8e-120 Tropomyosin OS=Homarus americanus GN=TM1 PE=1 SV=1 PF05557//PF00769//PF10473//PF05739//PF06160//PF16716//PF04111//PF01929//PF02601//PF08702//PF07926//PF06109//PF14073//PF06008//PF06009//PF00435 Mitotic checkpoint protein//Ezrin/radixin/moesin family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//SNARE domain//Septation ring formation regulator, EzrA//Bone marrow stromal antigen 2//Autophagy protein Apg6//Ribosomal protein L14//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//TPR/MLP1/MLP2-like protein//Haemolysin E (HlyE)//Centrosome localisation domain of Cep57//Laminin Domain I//Laminin Domain II//Spectrin repeat GO:0051258//GO:0006914//GO:0009405//GO:0007165//GO:0030334//GO:0044179//GO:0006308//GO:0007155//GO:0030155//GO:0007094//GO:0051607//GO:0006412//GO:0042254//GO:0045995//GO:0006606//GO:0030168//GO:0000921 protein polymerization//autophagy//pathogenesis//signal transduction//regulation of cell migration//hemolysis in other organism//DNA catabolic process//cell adhesion//regulation of cell adhesion//mitotic spindle assembly checkpoint//defense response to virus//translation//ribosome biogenesis//regulation of embryonic development//protein import into nucleus//platelet activation//septin ring assembly GO:0042803//GO:0043015//GO:0008855//GO:0005515//GO:0042802//GO:0003735//GO:0005102//GO:0008134//GO:0045502//GO:0030674//GO:0008092 protein homodimerization activity//gamma-tubulin binding//exodeoxyribonuclease VII activity//protein binding//identical protein binding//structural constituent of ribosome//receptor binding//transcription factor binding//dynein binding//protein binding, bridging//cytoskeletal protein binding GO:0005737//GO:0005840//GO:0005622//GO:0005940//GO:0016021//GO:0005577//GO:0009318//GO:0045298//GO:0019898//GO:0005667//GO:0030286 cytoplasm//ribosome//intracellular//septin ring//integral component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//tubulin complex//extrinsic component of membrane//transcription factor complex//dynein complex KOG1003 Actin filament-coating protein tropomyosin Cluster-8309.52065 BF_2 129.12 0.93 6101 642920114 XP_008192211.1 1223 6.1e-131 PREDICTED: E3 ubiquitin-protein ligase SH3RF1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K12171 SH3RF, POSH E3 ubiquitin-protein ligase SH3RF http://www.genome.jp/dbget-bin/www_bget?ko:K12171 Q6NRD3 665 1.3e-67 E3 ubiquitin-protein ligase SH3RF1 OS=Xenopus laevis GN=sh3rf1 PE=1 SV=1 PF00097//PF14634//PF17123//PF00096//PF16622//PF14604//PF00018//PF13912//PF09360//PF02892//PF13639//PF13465 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//RING-like zinc finger//Zinc finger, C2H2 type//zinc-finger C2H2-type//Variant SH3 domain//SH3 domain//C2H2-type zinc finger//Iron-binding zinc finger CDGSH type//BED zinc finger//Ring finger domain//Zinc-finger double domain -- -- GO:0046872//GO:0005515//GO:0003677//GO:0051537//GO:0008270 metal ion binding//protein binding//DNA binding//2 iron, 2 sulfur cluster binding//zinc ion binding GO:0043231 intracellular membrane-bounded organelle -- -- Cluster-8309.52067 BF_2 33.25 0.54 2841 780649216 XP_011689959.1 1304 1.1e-140 PREDICTED: uncharacterized protein LOC105451287 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52069 BF_2 41.92 1.50 1456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52073 BF_2 40.38 1.07 1863 642910713 XP_008200528.1 263 3.9e-20 PREDICTED: serine-arginine protein 55-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 Q08170 243 3.3e-19 Serine/arginine-rich splicing factor 4 OS=Homo sapiens GN=SRSF4 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.52075 BF_2 19.00 10.05 363 642917912 XP_008191379.1 211 8.0e-15 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52076 BF_2 279.62 7.71 1804 642917912 XP_008191379.1 1059 1.9e-112 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O97951 557 1.2e-55 UDP-glucuronosyltransferase 2B18 OS=Macaca fascicularis GN=UGT2B18 PE=1 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.52077 BF_2 7.76 0.85 667 478259666 ENN79510.1 176 1.7e-10 hypothetical protein YQE_03973, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52078 BF_2 1.00 0.33 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52083 BF_2 3.00 0.52 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52087 BF_2 6.00 0.56 737 332376162 AEE63221.1 273 1.1e-21 unknown [Dendroctonus ponderosae]>gi|478261356|gb|ENN80760.1| hypothetical protein YQE_02821, partial [Dendroctonus ponderosae]>gi|546678771|gb|ERL89323.1| hypothetical protein D910_06695 [Dendroctonus ponderosae] 765338024 XM_011494945.1 62 1.1033e-21 Aedes aegypti AAEL004475-RB mRNA K05756 ARPC3 actin related protein 2/3 complex, subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05756 Q9JM76 213 3.9e-16 Actin-related protein 2/3 complex subunit 3 OS=Mus musculus GN=Arpc3 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG3155 Actin-related protein Arp2/3 complex, subunit ARPC3 Cluster-8309.52090 BF_2 29.00 0.87 1684 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52091 BF_2 557.00 18.52 1545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52092 BF_2 566.69 9.74 2720 189241705 XP_967022.2 2036 1.4e-225 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q94502 1391 3.7e-152 Neutral alpha-glucosidase AB OS=Dictyostelium discoideum GN=modA PE=3 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.52095 BF_2 2.00 0.55 438 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52097 BF_2 196.80 0.86 9902 642928417 XP_008193778.1 1636 1.3e-178 PREDICTED: transcriptional regulator ATRX homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 F4HW51 979 8.0e-104 Protein CHROMATIN REMODELING 20 OS=Arabidopsis thaliana GN=ATRX PE=2 SV=2 PF00176//PF02729 SNF2 family N-terminal domain//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0006520 cellular amino acid metabolic process GO:0005524//GO:0016743 ATP binding//carboxyl- or carbamoyltransferase activity -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.52098 BF_2 58.85 2.09 1467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08064//PF00125 UME (NUC010) domain//Core histone H2A/H2B/H3/H4 GO:0009069//GO:0016310 serine family amino acid metabolic process//phosphorylation GO:0003677//GO:0004674 DNA binding//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.5210 BF_2 39.11 0.73 2525 642935762 XP_008198164.1 1462 4.9e-159 PREDICTED: uncharacterized protein C2orf42 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SYX3 696 1.3e-71 Uncharacterized protein C2orf42 homolog OS=Bos taurus PE=2 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.52100 BF_2 262.64 12.36 1176 332373564 AEE61923.1 917 3.5e-96 unknown [Dendroctonus ponderosae]>gi|478264341|gb|ENN82218.1| hypothetical protein YQE_01408, partial [Dendroctonus ponderosae]>gi|478266738|gb|ENN82887.1| hypothetical protein YQE_00749, partial [Dendroctonus ponderosae]>gi|546683553|gb|ERL93351.1| hypothetical protein D910_10643 [Dendroctonus ponderosae] 644995449 XM_001599589.3 181 1.26227e-87 PREDICTED: Nasonia vitripennis ADP-ribosylation factor-like protein 1 (LOC100114707), mRNA K07942 ARL1 ADP-ribosylation factor-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07942 P25160 807 8.3e-85 ADP-ribosylation factor-like protein 1 OS=Drosophila melanogaster GN=Arl1 PE=2 SV=5 PF01926//PF08477//PF02421//PF00025//PF00005//PF03193//PF04670//PF10662//PF00071//PF00503 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Ferrous iron transport protein B//ADP-ribosylation factor family//ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ethanolamine utilisation - propanediol utilisation//Ras family//G-protein alpha subunit GO:0007186//GO:0015684//GO:0007264//GO:0006576//GO:0007165 G-protein coupled receptor signaling pathway//ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process//signal transduction GO:0019001//GO:0004871//GO:0016887//GO:0005525//GO:0031683//GO:0005524//GO:0015093//GO:0003924 guanyl nucleotide binding//signal transducer activity//ATPase activity//GTP binding//G-protein beta/gamma-subunit complex binding//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane KOG0070 GTP-binding ADP-ribosylation factor Arf1 Cluster-8309.52102 BF_2 22.00 1.72 823 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52106 BF_2 25.78 0.34 3416 642937968 XP_008199148.1 291 4.0e-23 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.52107 BF_2 49.23 1.21 1987 642937970 XP_008199149.1 274 2.2e-21 PREDICTED: ATP-binding cassette sub-family A member 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52111 BF_2 3044.34 122.59 1326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.52116 BF_2 112.84 1.82 2875 86515410 NP_001034529.1 819 2.0e-84 cytochrome P450, family 4, subfamily Q, polypeptide 4 precursor [Tribolium castaneum]>gi|7804914|gb|AAF70178.1|AF251548_1 cytochrome P450 monooxigenase CYP4Q4 [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 526 7.8e-52 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0016491//GO:0020037//GO:0005488//GO:0016705 iron ion binding//oxidoreductase activity//heme binding//binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.52117 BF_2 256.51 8.69 1522 270014308 EFA10756.1 1447 1.6e-157 cytochrome P450-like protein [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1017 4.8e-109 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067//PF01618 Cytochrome P450//MotA/TolQ/ExbB proton channel family GO:0015031//GO:0055114//GO:0006810 protein transport//oxidation-reduction process//transport GO:0005506//GO:0020037//GO:0008565//GO:0016705 iron ion binding//heme binding//protein transporter activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016020 membrane -- -- Cluster-8309.52120 BF_2 44.16 0.57 3522 642927427 XP_008195268.1 1097 1.4e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52121 BF_2 60.00 5.41 751 56112341 AAV71145.1 1156 4.4e-124 ribosomal protein L10 [Callinectes sapidus] 56112340 AY822650.1 410 0 Callinectes sapidus ribosomal protein L10 mRNA, complete cds K02866 RP-L10e, RPL10 large subunit ribosomal protein L10e http://www.genome.jp/dbget-bin/www_bget?ko:K02866 O61231 1002 1.3e-107 60S ribosomal protein L10 OS=Drosophila melanogaster GN=RpL10 PE=1 SV=1 PF00252 Ribosomal protein L16p/L10e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0857 60s ribosomal protein L10 Cluster-8309.52122 BF_2 32.00 4.67 574 410925912 XP_003976423.1 581 1.6e-57 PREDICTED: 60S ribosomal protein L18a [Takifugu rubripes] 545198928 XM_005604118.1 113 3.77909e-50 PREDICTED: Equus caballus ribosomal protein L18a (RPL18A), mRNA K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q7ZWJ4 580 8.5e-59 60S ribosomal protein L18a OS=Danio rerio GN=rpl18a PE=2 SV=1 PF01775 Ribosomal L18ae/LX protein domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-8309.52127 BF_2 91.60 1.55 2754 532058550 XP_005371968.1 469 7.4e-44 PREDICTED: zinc finger protein 208-like [Microtus ochrogaster] 158294380 XM_315566.4 143 4.00002e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 Q9P2J8 437 1.6e-41 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF12678//PF17123//PF07776//PF00097//PF00096//PF06003//PF12861//PF13912//PF16622//PF13465//PF13639 RING-H2 zinc finger//RING-like zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C2H2 type//Survival motor neuron protein (SMN)//Anaphase-promoting complex subunit 11 RING-H2 finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Ring finger domain GO:0016567//GO:0006397 protein ubiquitination//mRNA processing GO:0005515//GO:0004842//GO:0003723//GO:0046872//GO:0008270 protein binding//ubiquitin-protein transferase activity//RNA binding//metal ion binding//zinc ion binding GO:0005680//GO:0005634//GO:0005737 anaphase-promoting complex//nucleus//cytoplasm -- -- Cluster-8309.52129 BF_2 45.73 1.27 1791 724860998 XP_010368879.1 508 1.4e-48 PREDICTED: zinc finger protein 107-like, partial [Rhinopithecus roxellana] 158294380 XM_315566.4 143 2.58508e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 P17035 450 3.2e-43 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF00096//PF00097//PF17123//PF12678//PF13639//PF07975//PF13465//PF16622//PF00412//PF12861//PF13912 Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//Ring finger domain//TFIIH C1-like domain//Zinc-finger double domain//zinc-finger C2H2-type//LIM domain//Anaphase-promoting complex subunit 11 RING-H2 finger//C2H2-type zinc finger GO:0006281//GO:0016567 DNA repair//protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.52131 BF_2 16.73 0.36 2236 488508184 XP_004446587.1 476 9.3e-45 PREDICTED: zinc finger protein 624 isoform X4 [Dasypus novemcinctus] 158294380 XM_315566.4 143 3.24018e-66 Anopheles gambiae str. PEST AGAP005562-PA (AgaP_AGAP005562) mRNA, complete cds K10611 RBX2, ROC2, RNF7 RING-box protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10611 Q9P2J8 416 3.5e-39 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF13639//PF13465//PF12861//PF13912//PF00096//PF07776//PF00097//PF17123//PF12678 Ring finger domain//Zinc-finger double domain//Anaphase-promoting complex subunit 11 RING-H2 finger//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005634//GO:0005680 nucleus//anaphase-promoting complex -- -- Cluster-8309.52134 BF_2 75.28 3.66 1147 189240296 XP_973610.2 719 3.2e-73 PREDICTED: microsomal triglyceride transfer protein large subunit [Tribolium castaneum]>gi|270011566|gb|EFA08014.1| hypothetical protein TcasGA2_TC005603 [Tribolium castaneum] -- -- -- -- -- K14463 MTTP, MTP microsomal triglyceride transfer protein large subunit http://www.genome.jp/dbget-bin/www_bget?ko:K14463 P55158 214 4.7e-16 Microsomal triglyceride transfer protein large subunit OS=Mesocricetus auratus GN=MTTP PE=2 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52138 BF_2 20.82 0.43 2323 642922790 XP_008193326.1 883 6.2e-92 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BJD1 469 2.6e-45 Inter-alpha-trypsin inhibitor heavy chain H5 OS=Mus musculus GN=Itih5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52140 BF_2 95.80 0.96 4474 270017202 EFA13648.1 1715 4.0e-188 hypothetical protein TcasGA2_TC015886 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 184 5.5e-12 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00075//PF00589//PF05869//PF16497//PF13495 RNase H//Phage integrase family//DNA N-6-adenine-methyltransferase (Dam)//MHC-I family domain//Phage integrase, N-terminal SAM-like domain GO:0032775//GO:0006955//GO:0006310//GO:0006306//GO:0051252//GO:0015074 DNA methylation on adenine//immune response//DNA recombination//DNA methylation//regulation of RNA metabolic process//DNA integration GO:0003677//GO:0003676//GO:0009007//GO:0004523 DNA binding//nucleic acid binding//site-specific DNA-methyltransferase (adenine-specific) activity//RNA-DNA hybrid ribonuclease activity -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.52144 BF_2 161.66 1.75 4143 546684929 ERL94511.1 314 1.0e-25 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF00096 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.52145 BF_2 86.01 3.25 1395 91093220 XP_967110.1 1225 8.1e-132 PREDICTED: putative Golgi pH regulator C [Tribolium castaneum]>gi|270016591|gb|EFA13037.1| hypothetical protein TcasGA2_TC010568 [Tribolium castaneum] 312070078 XM_003137932.1 38 4.68453e-08 Loa loa hypothetical protein (LOAG_02394) mRNA, partial cds -- -- -- -- B5X1G3 828 3.6e-87 Golgi pH regulator OS=Salmo salar GN=gpr89 PE=2 SV=1 PF12537 The Golgi pH Regulator (GPHR) Family N-terminal -- -- -- -- GO:0016020 membrane KOG2417 Predicted G-protein coupled receptor Cluster-8309.52146 BF_2 292.00 2.21 5807 189242051 XP_968641.2 3234 0.0e+00 PREDICTED: DNA replication licensing factor Mcm3 [Tribolium castaneum]>gi|270015933|gb|EFA12381.1| hypothetical protein TcasGA2_TC002088 [Tribolium castaneum] 752884597 XM_011261744.1 285 9.81067e-145 PREDICTED: Camponotus floridanus DNA replication licensing factor Mcm3 (LOC105253613), transcript variant X2, mRNA K02541 MCM3 DNA replication licensing factor MCM3 http://www.genome.jp/dbget-bin/www_bget?ko:K02541 Q9XYU1 2771 7.5e-312 DNA replication licensing factor Mcm3 OS=Drosophila melanogaster GN=Mcm3 PE=1 SV=1 PF07728//PF07726//PF00493 AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//MCM2/3/5 family GO:0006260//GO:0006270 DNA replication//DNA replication initiation GO:0005524//GO:0003677//GO:0016887//GO:0017111 ATP binding//DNA binding//ATPase activity//nucleoside-triphosphatase activity GO:0005634 nucleus KOG0479 DNA replication licensing factor, MCM3 component Cluster-8309.52147 BF_2 12.00 0.32 1848 270015831 EFA12279.1 637 1.6e-63 hypothetical protein TcasGA2_TC005264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52148 BF_2 10.00 0.41 1298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52156 BF_2 79.32 1.27 2894 91078182 XP_967647.1 1847 1.3e-203 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCI6 995 3.2e-106 Beta-galactosidase-1-like protein 3 OS=Homo sapiens GN=GLB1L3 PE=2 SV=3 PF02449//PF00150 Beta-galactosidase//Cellulase (glycosyl hydrolase family 5) GO:0006687//GO:0005975//GO:0046486//GO:0006027//GO:0006012 glycosphingolipid metabolic process//carbohydrate metabolic process//glycerolipid metabolic process//glycosaminoglycan catabolic process//galactose metabolic process GO:0004553//GO:0004565//GO:0016798 hydrolase activity, hydrolyzing O-glycosyl compounds//beta-galactosidase activity//hydrolase activity, acting on glycosyl bonds GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.52157 BF_2 2.00 2.17 314 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52162 BF_2 169.71 3.66 2228 91091974 XP_968950.1 1097 9.0e-117 PREDICTED: protein prenyltransferase alpha subunit repeat-containing protein 1-B [Tribolium castaneum]>gi|270001151|gb|EEZ97598.1| hypothetical protein TcasGA2_TC011467 [Tribolium castaneum] -- -- -- -- -- K14137 PTAR1 protein prenyltransferase alpha subunit repeat containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14137 A1L3L1 401 1.9e-37 Protein prenyltransferase alpha subunit repeat-containing protein 1-B (Fragment) OS=Xenopus laevis GN=ptar1-b PE=2 SV=1 PF01239 Protein prenyltransferase alpha subunit repeat GO:0018342 protein prenylation GO:0008318 protein prenyltransferase activity -- -- -- -- Cluster-8309.52163 BF_2 428.59 83.78 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52164 BF_2 111.72 2.43 2211 332376709 AEE63494.1 1235 8.9e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q6QHF9 464 9.3e-45 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.52169 BF_2 25.46 0.52 2331 332376741 AEE63510.1 343 2.6e-29 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00552 GNMT glycine N-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00552 Q29513 156 5.1e-09 Glycine N-methyltransferase (Fragment) OS=Oryctolagus cuniculus GN=GNMT PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52171 BF_2 445.03 8.96 2364 189233838 XP_001808952.1 2559 2.8e-286 PREDICTED: sodium/hydrogen exchanger 7 isoform X2 [Tribolium castaneum] 556959399 XM_005990356.1 38 8.02226e-08 PREDICTED: Latimeria chalumnae solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6), transcript variant X3, mRNA K12041 SLC9A6_7, NHE6_7 solute carrier family 9 (sodium/hydrogen exchanger), member 6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K12041 Q8BLV3 1370 8.7e-150 Sodium/hydrogen exchanger 7 OS=Mus musculus GN=Slc9a7 PE=2 SV=1 PF00999 Sodium/hydrogen exchanger family GO:0055085//GO:0006885//GO:0006812 transmembrane transport//regulation of pH//cation transport GO:0015299 solute:proton antiporter activity GO:0016021 integral component of membrane KOG1965 Sodium/hydrogen exchanger protein Cluster-8309.52173 BF_2 661.11 6.38 4625 642921981 XP_008192968.1 2946 0.0e+00 PREDICTED: neuroligin-3 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 Q8N0W4 891 6.0e-94 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF06330 alpha/beta hydrolase fold//Trichodiene synthase (TRI5) GO:0008152//GO:0016106//GO:0016114 metabolic process//sesquiterpenoid biosynthetic process//terpenoid biosynthetic process GO:0016787//GO:0045482 hydrolase activity//trichodiene synthase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.52174 BF_2 64.77 0.46 6116 642935532 XP_008198047.1 2202 1.8e-244 PREDICTED: type I inositol 1,4,5-trisphosphate 5-phosphatase isoform X1 [Tribolium castaneum]>gi|270013328|gb|EFA09776.1| hypothetical protein TcasGA2_TC011918 [Tribolium castaneum] -- -- -- -- -- K01106 E3.1.3.56 inositol-1,4,5-trisphosphate 5-phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01106 Q14642 962 4.6e-102 Type I inositol 1,4,5-trisphosphate 5-phosphatase OS=Homo sapiens GN=INPP5A PE=1 SV=1 -- -- GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG1976 Inositol polyphosphate 5-phosphatase, type I Cluster-8309.52178 BF_2 148.71 1.01 6422 642913900 XP_008201205.1 5196 0.0e+00 PREDICTED: anaphase-promoting complex subunit 1 [Tribolium castaneum] -- -- -- -- -- K03348 APC1 anaphase-promoting complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03348 Q9H1A4 2593 3.6e-291 Anaphase-promoting complex subunit 1 OS=Homo sapiens GN=ANAPC1 PE=1 SV=1 PF12859//PF07475 Anaphase-promoting complex subunit 1//HPr Serine kinase C-terminal domain GO:0000160//GO:0006109//GO:0016310 phosphorelay signal transduction system//regulation of carbohydrate metabolic process//phosphorylation GO:0004672//GO:0000155//GO:0005524 protein kinase activity//phosphorelay sensor kinase activity//ATP binding GO:0005680//GO:0009365 anaphase-promoting complex//protein histidine kinase complex KOG1858 Anaphase-promoting complex (APC), subunit 1 (meiotic check point regulator/Tsg24) Cluster-8309.52181 BF_2 348.68 10.90 1625 91078370 XP_974092.1 1641 5.5e-180 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003978|gb|EFA00426.1| hypothetical protein TcasGA2_TC003280 [Tribolium castaneum] 253560541 GQ232416.1 50 1.16886e-14 Culex pipiens pipiens putative acyl-CoA dehydrogenase (ACD-1) mRNA, partial cds K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1520 2.4e-167 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF02770//PF02771//PF00441 Acyl-CoA dehydrogenase, middle domain//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain GO:0006118//GO:0008152//GO:0055114 obsolete electron transport//metabolic process//oxidation-reduction process GO:0003995//GO:0050660//GO:0016627 acyl-CoA dehydrogenase activity//flavin adenine dinucleotide binding//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.52185 BF_2 282.09 7.04 1964 642918672 XP_968126.3 1009 1.3e-106 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X1 [Tribolium castaneum] 657589840 XM_008301108.1 80 2.98393e-31 PREDICTED: Stegastes partitus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (smarce1), transcript variant X4, mRNA K11651 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11651 O54941 653 1.0e-66 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus musculus GN=Smarce1 PE=1 SV=1 PF01496//PF05478 V-type ATPase 116kDa subunit family//Prominin GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179//GO:0016021 proton-transporting V-type ATPase, V0 domain//integral component of membrane KOG4715 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin Cluster-8309.52188 BF_2 46.34 0.93 2382 817206334 XP_012279103.1 167 6.7e-09 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q [Orussus abietinus]>gi|817206336|ref|XP_012279104.1| PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q9BRB3 141 2.8e-07 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q OS=Homo sapiens GN=PIGQ PE=1 SV=3 PF05024//PF01363//PF02148//PF00641 N-acetylglucosaminyl transferase component (Gpi1)//FYVE zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//Zn-finger in Ran binding protein and others GO:0006506 GPI anchor biosynthetic process GO:0046872//GO:0008270//GO:0017176 metal ion binding//zinc ion binding//phosphatidylinositol N-acetylglucosaminyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.52189 BF_2 567.19 15.23 1845 728418383 AIY68367.1 569 1.3e-55 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P07882 353 5.8e-32 Bile salt-activated lipase OS=Rattus norvegicus GN=Cel PE=1 SV=2 PF00326//PF07859//PF13409 Prolyl oligopeptidase family//alpha/beta hydrolase fold//Glutathione S-transferase, N-terminal domain GO:0008152//GO:0006508 metabolic process//proteolysis GO:0005515//GO:0008236//GO:0016787 protein binding//serine-type peptidase activity//hydrolase activity -- -- -- -- Cluster-8309.52190 BF_2 1469.41 184.11 621 728417299 AIY68339.1 430 5.5e-40 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52191 BF_2 913.00 48.79 1070 749779245 XP_011144213.1 377 1.3e-33 PREDICTED: trypsin-1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- P35037 338 1.8e-30 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52192 BF_2 2.25 0.73 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52193 BF_2 232.92 2.79 3785 91082137 XP_966595.1 1646 3.4e-180 PREDICTED: arrestin homolog [Tribolium castaneum]>gi|270008184|gb|EFA04632.1| arrestin 1 [Tribolium castaneum] 571574522 XR_409690.1 172 4.17558e-82 PREDICTED: Apis mellifera arrestin 1 (Arr1), transcript variant X3, misc_RNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1351 2.2e-147 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 -- -- GO:0007165 signal transduction -- -- -- -- KOG3865 Arrestin Cluster-8309.52195 BF_2 35.00 2.42 893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52197 BF_2 59.43 0.67 3995 861619004 KMQ86923.1 990 4.1e-104 mariner transposase [Lasius niger] 689905592 LM386654.1 68 2.86859e-24 Hymenolepis diminuta genome assembly H_diminuta_Denmark ,scaffold HDID_contig0002140 -- -- -- -- Q7JQ07 390 6.4e-36 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF06056//PF11889 Putative ATPase subunit of terminase (gpP-like)//Domain of unknown function (DUF3409) GO:0006508//GO:0019069//GO:0006144 proteolysis//viral capsid assembly//purine nucleobase metabolic process GO:0003968//GO:0070008//GO:0004197//GO:0017111//GO:0004252//GO:0016817//GO:0005524 RNA-directed RNA polymerase activity//serine-type exopeptidase activity//cysteine-type endopeptidase activity//nucleoside-triphosphatase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//ATP binding GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.52199 BF_2 40.60 0.45 4083 861619004 KMQ86923.1 756 5.8e-77 mariner transposase [Lasius niger] 689905592 LM386654.1 65 1.36429e-22 Hymenolepis diminuta genome assembly H_diminuta_Denmark ,scaffold HDID_contig0002140 K11433 SETMAR histone-lysine N-methyltransferase SETMAR http://www.genome.jp/dbget-bin/www_bget?ko:K11433 Q7JQ07 314 4.2e-27 Mariner Mos1 transposase OS=Drosophila mauritiana GN=mariner\T PE=1 SV=1 PF05354//PF06056 Phage Head-Tail Attachment//Putative ATPase subunit of terminase (gpP-like) GO:0019069//GO:0019068 viral capsid assembly//virion assembly GO:0005524 ATP binding GO:0019028 viral capsid -- -- Cluster-8309.52201 BF_2 117.96 1.29 4112 642923805 XP_008193890.1 1839 1.5e-202 PREDICTED: RNA-binding protein 39 [Tribolium castaneum]>gi|270007747|gb|EFA04195.1| hypothetical protein TcasGA2_TC014444 [Tribolium castaneum] -- -- -- -- -- K13091 RBM39, RNPC2 RNA-binding protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K13091 Q5RC80 1312 8.1e-143 RNA-binding protein 39 OS=Pongo abelii GN=RBM39 PE=2 SV=1 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif GO:0006397 mRNA processing GO:0003676//GO:0000166//GO:0003723 nucleic acid binding//nucleotide binding//RNA binding GO:0005634 nucleus KOG0147 Transcriptional coactivator CAPER (RRM superfamily) Cluster-8309.52204 BF_2 114.07 1.71 3074 642911589 XP_008200663.1 795 1.3e-81 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 387 1.1e-35 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52205 BF_2 56.44 0.86 3025 642911589 XP_008200663.1 1363 1.8e-147 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 362 8.5e-33 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52207 BF_2 188.00 5.65 1679 642926835 XP_008195033.1 1501 9.7e-164 PREDICTED: cyclin-L1 [Tribolium castaneum]>gi|270009183|gb|EFA05631.1| hypothetical protein TcasGA2_TC015839 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S94 965 5.7e-103 Cyclin-L2 OS=Homo sapiens GN=CCNL2 PE=1 SV=1 PF00382//PF02984 Transcription factor TFIIB repeat//Cyclin, C-terminal domain GO:0006396//GO:0000079//GO:0006355 RNA processing//regulation of cyclin-dependent protein serine/threonine kinase activity//regulation of transcription, DNA-templated GO:0017025//GO:0019901 TBP-class protein binding//protein kinase binding GO:0005634 nucleus KOG0835 Cyclin L Cluster-8309.52208 BF_2 263.11 7.63 1729 642940001 XP_008198792.1 590 4.3e-58 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52209 BF_2 87.63 2.24 1923 642940001 XP_008198792.1 410 3.6e-37 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52210 BF_2 231.00 13.24 1017 270003522 EEZ99969.1 283 1.0e-22 hypothetical protein TcasGA2_TC002765 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52211 BF_2 321.25 7.94 1980 642940001 XP_008198792.1 410 3.7e-37 PREDICTED: uncharacterized protein LOC103314449 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52214 BF_2 5.00 0.47 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52217 BF_2 2.00 0.34 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52220 BF_2 37.00 6.40 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52221 BF_2 2.00 9.92 253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52222 BF_2 74.00 5.97 806 668448475 KFB38130.1 158 2.5e-08 hypothetical protein ZHAS_00005405 [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52223 BF_2 747.13 3.64 8883 642935083 XP_008197877.1 3815 0.0e+00 PREDICTED: calmodulin-binding transcription activator 2-like isoform X3 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 651 7.7e-66 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF00023//PF00612//PF01833//PF13606//PF03859//PF00899//PF10371 Ankyrin repeat//IQ calmodulin-binding motif//IPT/TIG domain//Ankyrin repeat//CG-1 domain//ThiF family//Domain of unknown function GO:0055114 oxidation-reduction process GO:0003677//GO:0016903//GO:0008641//GO:0005515 DNA binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors//small protein activating enzyme activity//protein binding GO:0005634 nucleus KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.52227 BF_2 106.78 2.01 2513 332373500 AEE61891.1 743 1.1e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M882 290 1.6e-24 Ribonuclease P protein subunit p29 OS=Rattus norvegicus GN=Pop4 PE=2 SV=1 PF01868 Domain of unknown function UPF0086 GO:0051252//GO:0008033//GO:0006364//GO:0006379 regulation of RNA metabolic process//tRNA processing//rRNA processing//mRNA cleavage GO:0004540//GO:0003723 ribonuclease activity//RNA binding GO:0000172//GO:0030677 ribonuclease MRP complex//ribonuclease P complex KOG4046 RNase MRP and P, subunit POP4/p29 Cluster-8309.52230 BF_2 201.28 0.72 12017 642935135 XP_008197902.1 8189 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19526 VPS13B vacuolar protein sorting-associated protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K19526 Q80TY5 1009 3.2e-107 Vacuolar protein sorting-associated protein 13B OS=Mus musculus GN=Vps13b PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.52234 BF_2 482.70 10.65 2184 91086839 XP_974133.1 262 5.9e-20 PREDICTED: transmembrane protein 14C [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQN6 158 2.8e-09 Transmembrane protein 14C OS=Mus musculus GN=Tmem14c PE=1 SV=1 PF03647 Transmembrane proteins 14C -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.52235 BF_2 114.30 2.88 1947 270009698 EFA06146.1 229 3.5e-16 hypothetical protein TcasGA2_TC008990 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQN6 141 2.3e-07 Transmembrane protein 14C OS=Mus musculus GN=Tmem14c PE=1 SV=1 PF03647 Transmembrane proteins 14C -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.52237 BF_2 493.00 6.75 3344 91079939 XP_968354.1 2365 1.3e-263 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003259|gb|EEZ99706.1| hypothetical protein TcasGA2_TC002467 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 O46432 1671 1.5e-184 Lysosomal alpha-mannosidase OS=Felis catus GN=MAN2B1 PE=2 SV=1 PF01074//PF07748//PF09261 Glycosyl hydrolases family 38 N-terminal domain//Glycosyl hydrolases family 38 C-terminal domain//Alpha mannosidase, middle domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923//GO:0004559//GO:0004553//GO:0005488//GO:0008270 mannosidase activity//alpha-mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//binding//zinc ion binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.52238 BF_2 67.00 0.56 5320 642936535 XP_970405.2 5431 0.0e+00 PREDICTED: guanylate cyclase 32E [Tribolium castaneum] 642936534 XM_965312.2 763 0 PREDICTED: Tribolium castaneum guanylate cyclase 32E (LOC658966), mRNA -- -- -- -- Q07553 2059 2.5e-229 Guanylate cyclase 32E OS=Drosophila melanogaster GN=Gyc32E PE=1 SV=4 PF00069//PF02198//PF07714//PF06984//PF00211//PF07701 Protein kinase domain//Sterile alpha motif (SAM)/Pointed domain//Protein tyrosine kinase//Mitochondrial 39-S ribosomal protein L47 (MRP-L47)//Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated GO:0006144//GO:0006412//GO:0006182//GO:0006468//GO:0046039//GO:0035556//GO:0042254//GO:0009190 purine nucleobase metabolic process//translation//cGMP biosynthetic process//protein phosphorylation//GTP metabolic process//intracellular signal transduction//ribosome biogenesis//cyclic nucleotide biosynthetic process GO:0004672//GO:0016849//GO:0005524//GO:0003735//GO:0043565//GO:0004383 protein kinase activity//phosphorus-oxygen lyase activity//ATP binding//structural constituent of ribosome//sequence-specific DNA binding//guanylate cyclase activity GO:0005634//GO:0005761//GO:0005840 nucleus//mitochondrial ribosome//ribosome KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.52239 BF_2 187.09 10.89 1006 871228493 XP_012937210.1 218 3.4e-15 PREDICTED: uncharacterized protein LOC106011594 [Aplysia californica] 578359011 KJ186851.1 48 9.24614e-14 Apriona japonica glycoside hydrolase family 5 subfamily 2 (gh5-4) mRNA, complete cds -- -- -- -- O76217 142 9.2e-08 Peritrophin-1 OS=Anopheles gambiae GN=Aper1 PE=2 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.52240 BF_2 45.55 2.32 1110 332374188 AEE62235.1 427 2.2e-39 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 327 3.6e-29 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52241 BF_2 811.38 43.08 1075 332374188 AEE62235.1 427 2.1e-39 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P00771 327 3.5e-29 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52243 BF_2 52.63 0.54 4329 189240845 XP_001812763.1 2225 2.8e-247 PREDICTED: AP-1 complex subunit gamma-1 isoform X1 [Tribolium castaneum] 462318772 APGK01044292.1 183 3.67025e-88 Dendroctonus ponderosae Seq01044302, whole genome shotgun sequence K12391 AP1G1 AP-1 complex subunit gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K12391 P22892 1431 1.3e-156 AP-1 complex subunit gamma-1 OS=Mus musculus GN=Ap1g1 PE=1 SV=3 PF06213//PF02724//PF09726//PF02535//PF02883//PF01080//PF08367//PF04931//PF01602 Cobalamin biosynthesis protein CobT//CDC45-like protein//Transmembrane protein//ZIP Zinc transporter//Adaptin C-terminal domain//Presenilin//Peptidase M16C associated//DNA polymerase phi//Adaptin N terminal region GO:0006508//GO:0030001//GO:0006351//GO:0006260//GO:0009236//GO:0055085//GO:0006886//GO:0016192//GO:0006270 proteolysis//metal ion transport//transcription, DNA-templated//DNA replication//cobalamin biosynthetic process//transmembrane transport//intracellular protein transport//vesicle-mediated transport//DNA replication initiation GO:0046873//GO:0003677//GO:0004190//GO:0003887 metal ion transmembrane transporter activity//DNA binding//aspartic-type endopeptidase activity//DNA-directed DNA polymerase activity GO:0016020//GO:0030117//GO:0016021//GO:0030131//GO:0042575 membrane//membrane coat//integral component of membrane//clathrin adaptor complex//DNA polymerase complex KOG1062 Vesicle coat complex AP-1, gamma subunit Cluster-8309.52245 BF_2 17.00 0.49 1726 758213862 AJO62244.1 1758 1.6e-193 chemosensory ionotropic receptor IR6 [Tenebrio molitor] 195576599 XM_002078127.1 284 1.03425e-144 Drosophila simulans GD22688 (Dsim\GD22688), mRNA K05313 GRIN glutamate receptor, ionotropic, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05313 Q9Z2W9 466 4.2e-45 Glutamate receptor 3 OS=Mus musculus GN=Gria3 PE=1 SV=2 PF08114//PF10613//PF00060 ATPase proteolipid family//Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007268//GO:0007165//GO:0050790//GO:0006811 synaptic transmission//signal transduction//regulation of catalytic activity//ion transport GO:0005234//GO:0004970//GO:0030234 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity//enzyme regulator activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-8309.52246 BF_2 210.09 2.12 4442 642929566 XP_008195887.1 2710 1.7e-303 PREDICTED: uncharacterized protein LOC664242 isoform X2 [Tribolium castaneum]>gi|270009578|gb|EFA06026.1| hypothetical protein TcasGA2_TC008856 [Tribolium castaneum] 817214723 XM_012428143.1 47 1.50648e-12 PREDICTED: Orussus abietinus GTP-binding protein Rit2 (LOC105701416), partial mRNA -- -- -- -- O88667 266 1.7e-21 GTP-binding protein RAD OS=Mus musculus GN=Rrad PE=1 SV=1 PF01868//PF00498//PF08477//PF01105//PF03193//PF00025//PF00071 Domain of unknown function UPF0086//FHA domain//Ras of Complex, Roc, domain of DAPkinase//emp24/gp25L/p24 family/GOLD//Protein of unknown function, DUF258//ADP-ribosylation factor family//Ras family GO:0007264//GO:0009987//GO:0008033//GO:0051252//GO:0006364//GO:0006810//GO:0006379 small GTPase mediated signal transduction//cellular process//tRNA processing//regulation of RNA metabolic process//rRNA processing//transport//mRNA cleavage GO:0005525//GO:0004540//GO:0005515//GO:0003924//GO:0003723 GTP binding//ribonuclease activity//protein binding//GTPase activity//RNA binding GO:0000172//GO:0016021//GO:0030677 ribonuclease MRP complex//integral component of membrane//ribonuclease P complex KOG0395 Ras-related GTPase Cluster-8309.52251 BF_2 210.94 3.70 2675 727098983 AIY54303.1 1230 4.1e-132 TATA-box-binding protein [Colaphellus bowringi] 727098982 KJ534562.1 347 1.53666e-179 Colaphellus bowringi TATA-box-binding protein (TBP) mRNA, complete cds K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 P53361 1022 2.2e-109 TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1 PF13762//PF00352//PF00560 Mitochondrial splicing apparatus component//Transcription factor TFIID (or TATA-binding protein, TBP)//Leucine Rich Repeat GO:0000372//GO:0006352 Group I intron splicing//DNA-templated transcription, initiation GO:0003677//GO:0005515 DNA binding//protein binding GO:0030529 intracellular ribonucleoprotein complex KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.52253 BF_2 22.00 0.98 1223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52254 BF_2 70.27 1.14 2871 727098983 AIY54303.1 1230 4.4e-132 TATA-box-binding protein [Colaphellus bowringi] 727098982 KJ534562.1 347 1.64965e-179 Colaphellus bowringi TATA-box-binding protein (TBP) mRNA, complete cds K03120 TBP, tbp transcription initiation factor TFIID TATA-box-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K03120 P53361 1022 2.4e-109 TATA-box-binding protein OS=Spodoptera frugiperda GN=Tbp PE=2 SV=1 PF00560//PF00352//PF13762 Leucine Rich Repeat//Transcription factor TFIID (or TATA-binding protein, TBP)//Mitochondrial splicing apparatus component GO:0000372//GO:0006352 Group I intron splicing//DNA-templated transcription, initiation GO:0003677//GO:0005515 DNA binding//protein binding GO:0030529 intracellular ribonucleoprotein complex KOG3302 TATA-box binding protein (TBP), component of TFIID and TFIIIB Cluster-8309.52255 BF_2 39.69 0.78 2415 642917920 XP_008200607.1 2655 2.1e-297 PREDICTED: alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B [Tribolium castaneum] -- -- -- -- -- K00738 MGAT4A_B alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase A/B http://www.genome.jp/dbget-bin/www_bget?ko:K00738 Q6GMK0 1212 1.9e-131 Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B OS=Danio rerio GN=mgat4b PE=2 SV=1 PF01991//PF04666 ATP synthase (E/31 kDa) subunit//N-Acetylglucosaminyltransferase-IV (GnT-IV) conserved region GO:0005975//GO:0015992//GO:0015991//GO:0006119 carbohydrate metabolic process//proton transport//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0046961//GO:0016758 proton-transporting ATPase activity, rotational mechanism//transferase activity, transferring hexosyl groups GO:0016020//GO:0033178 membrane//proton-transporting two-sector ATPase complex, catalytic domain -- -- Cluster-8309.52258 BF_2 645.36 22.37 1494 91088311 XP_969566.1 1176 4.2e-126 PREDICTED: dipeptidase 1 [Tribolium castaneum]>gi|270012164|gb|EFA08612.1| hypothetical protein TcasGA2_TC006275 [Tribolium castaneum] -- -- -- -- -- K01273 DPEP membrane dipeptidase http://www.genome.jp/dbget-bin/www_bget?ko:K01273 P31430 772 1.2e-80 Dipeptidase 1 OS=Rattus norvegicus GN=Dpep1 PE=2 SV=2 PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0008238//GO:0016805 exopeptidase activity//dipeptidase activity -- -- KOG4127 Renal dipeptidase Cluster-8309.52259 BF_2 3.00 0.39 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.52260 BF_2 305.57 1.90 7017 642921434 XP_008192864.1 4129 0.0e+00 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X10 1853 2.5e-205 Ral GTPase-activating protein subunit beta OS=Homo sapiens GN=RALGAPB PE=1 SV=1 PF00237//PF02145//PF00876 Ribosomal protein L22p/L17e//Rap/ran-GAP//Innexin GO:0042254//GO:0006412//GO:0051056 ribosome biogenesis//translation//regulation of small GTPase mediated signal transduction GO:0003735//GO:0005096 structural constituent of ribosome//GTPase activator activity GO:0005840//GO:0005921 ribosome//gap junction KOG1711 Mitochondrial/chloroplast ribosomal protein L22 Cluster-8309.52263 BF_2 134.00 1.03 5719 642920285 XP_008192283.1 1874 1.9e-206 PREDICTED: extensin-2 [Tribolium castaneum]>gi|270005272|gb|EFA01720.1| hypothetical protein TcasGA2_TC007300 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52265 BF_2 1610.99 102.76 943 227018322 ACP18827.1 861 8.9e-90 chitin deacetylase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52266 BF_2 3493.27 150.06 1261 227018324 ACP18828.1 844 1.1e-87 chitin deacetylase 1 [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52269 BF_2 4.00 0.80 495 861638560 KMQ92556.1 317 5.6e-27 nuclease harbi1-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.52270 BF_2 5.00 0.42 785 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52272 BF_2 3.48 0.98 435 642918201 XP_008191408.1 422 3.3e-39 PREDICTED: zinc finger homeobox protein 4 isoform X1 [Tribolium castaneum] 642918204 XM_008193188.1 146 1.27279e-68 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA K09378 ATBF1 AT-binding transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09378 -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.52278 BF_2 236.28 1.33 7716 91092128 XP_972649.1 4445 0.0e+00 PREDICTED: splicing factor 3B subunit 3 isoform X1 [Tribolium castaneum]>gi|270004662|gb|EFA01110.1| hypothetical protein TcasGA2_TC010322 [Tribolium castaneum] 77623052 CT030548.1 392 0 Xenopus tropicalis finished cDNA, clone TGas034j22 K12830 SF3B3, SAP130, RSE1 splicing factor 3B subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K12830 Q15393 3985 0.0e+00 Splicing factor 3B subunit 3 OS=Homo sapiens GN=SF3B3 PE=1 SV=4 PF03178 CPSF A subunit region -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus KOG1898 Splicing factor 3b, subunit 3 Cluster-8309.52279 BF_2 190.11 6.46 1519 478259051 ENN78994.1 2113 9.5e-235 hypothetical protein YQE_04545, partial [Dendroctonus ponderosae]>gi|546678364|gb|ERL88997.1| hypothetical protein D910_06375 [Dendroctonus ponderosae] 571531346 XM_625072.4 309 1.14945e-158 PREDICTED: Apis mellifera males absent on the first (mof), transcript variant X2, mRNA K11308 MYST1, MOF, KAT8 histone acetyltransferase MYST1 http://www.genome.jp/dbget-bin/www_bget?ko:K11308 Q9D1P2 1677 1.4e-185 Histone acetyltransferase KAT8 OS=Mus musculus GN=Kat8 PE=1 SV=1 PF01853//PF14532//PF00583//PF13508 MOZ/SAS family//Sigma-54 interaction domain//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0008080//GO:0008134//GO:0016747//GO:0005524 N-acetyltransferase activity//transcription factor binding//transferase activity, transferring acyl groups other than amino-acyl groups//ATP binding GO:0005667 transcription factor complex KOG2747 Histone acetyltransferase (MYST family) Cluster-8309.52280 BF_2 187.31 1.18 6955 642924674 XP_008194391.1 1323 1.8e-142 PREDICTED: protein abrupt isoform X2 [Tribolium castaneum] 642924673 XM_008196169.1 334 6.78175e-172 PREDICTED: Tribolium castaneum protein abrupt (LOC663820), transcript variant X5, mRNA -- -- -- -- Q24174 633 7.4e-64 Protein abrupt OS=Drosophila melanogaster GN=ab PE=1 SV=2 PF04135//PF13465//PF00096//PF02892//PF13912//PF00651 Nucleolar RNA-binding protein, Nop10p family//Zinc-finger double domain//Zinc finger, C2H2 type//BED zinc finger//C2H2-type zinc finger//BTB/POZ domain GO:0001522//GO:0042254 pseudouridine synthesis//ribosome biogenesis GO:0030515//GO:0003677//GO:0046872//GO:0005515 snoRNA binding//DNA binding//metal ion binding//protein binding GO:0072588 box H/ACA RNP complex -- -- Cluster-8309.52281 BF_2 139.00 2.05 3124 642928964 XP_008195636.1 452 7.9e-42 PREDICTED: uncharacterized protein LOC103313636 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52282 BF_2 30.25 0.67 2163 795011494 XP_011872774.1 309 2.1e-25 PREDICTED: uncharacterized protein LOC105564750, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.52284 BF_2 22.00 2.77 619 642927016 XP_008195104.1 408 2.0e-37 PREDICTED: ATP-binding cassette sub-family A member 2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K05641 ABCA1 ATP-binding cassette, subfamily A (ABC1), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05641 P41233 256 3.4e-21 ATP-binding cassette sub-family A member 1 OS=Mus musculus GN=Abca1 PE=1 SV=4 PF13304//PF06414//PF03193//PF04310//PF00005 AAA domain, putative AbiEii toxin, Type IV TA system//Zeta toxin//Protein of unknown function, DUF258//MukB N-terminal//ABC transporter GO:0007059//GO:0030261 chromosome segregation//chromosome condensation GO:0005525//GO:0016301//GO:0016887//GO:0003924//GO:0005524//GO:0003677 GTP binding//kinase activity//ATPase activity//GTPase activity//ATP binding//DNA binding GO:0009295 nucleoid KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52285 BF_2 85.12 0.98 3907 478249703 ENN70211.1 2204 6.9e-245 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 1152 2.7e-124 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF13304//PF02170//PF00005//PF03152 AAA domain, putative AbiEii toxin, Type IV TA system//PAZ domain//ABC transporter//Ubiquitin fusion degradation protein UFD1 GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515//GO:0005524//GO:0016887 protein binding//ATP binding//ATPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52286 BF_2 88.86 1.06 3797 478249703 ENN70211.1 1542 3.9e-168 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 617 2.9e-62 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF00005//PF13304//PF03152 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//Ubiquitin fusion degradation protein UFD1 GO:0006511 ubiquitin-dependent protein catabolic process GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52288 BF_2 57.51 0.66 3959 478249703 ENN70211.1 1603 3.4e-175 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05643 ABCA3 ATP-binding cassette, subfamily A (ABC1), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05643 Q99758 628 1.6e-63 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF13304//PF00005//PF03152 AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Ubiquitin fusion degradation protein UFD1 GO:0006511 ubiquitin-dependent protein catabolic process GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.52289 BF_2 6705.68 120.87 2608 91078182 XP_967647.1 1847 1.1e-203 PREDICTED: beta-galactosidase-1-like protein 2 [Tribolium castaneum]>gi|270001359|gb|EEZ97806.1| hypothetical protein TcasGA2_TC000170 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCI6 995 2.9e-106 Beta-galactosidase-1-like protein 3 OS=Homo sapiens GN=GLB1L3 PE=2 SV=3 PF00150//PF02449 Cellulase (glycosyl hydrolase family 5)//Beta-galactosidase GO:0006012//GO:0006027//GO:0006687//GO:0005975//GO:0046486 galactose metabolic process//glycosaminoglycan catabolic process//glycosphingolipid metabolic process//carbohydrate metabolic process//glycerolipid metabolic process GO:0016798//GO:0004553//GO:0004565 hydrolase activity, acting on glycosyl bonds//hydrolase activity, hydrolyzing O-glycosyl compounds//beta-galactosidase activity GO:0009341 beta-galactosidase complex KOG0496 Beta-galactosidase Cluster-8309.52290 BF_2 2.00 0.50 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52291 BF_2 154.66 1.49 4638 189236877 XP_974696.2 4794 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1864 8.9e-207 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF03810//PF00822//PF05236 Importin-beta N-terminal domain//PMP-22/EMP/MP20/Claudin family//Transcription initiation factor TFIID component TAF4 family GO:0006886//GO:0006352 intracellular protein transport//DNA-templated transcription, initiation GO:0008536 Ran GTPase binding GO:0005669//GO:0016021 transcription factor TFIID complex//integral component of membrane KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.52292 BF_2 52.19 0.63 3750 189236877 XP_974696.2 4119 0.0e+00 PREDICTED: exportin-5 [Tribolium castaneum] -- -- -- -- -- K14289 XPO5 exportin-5 http://www.genome.jp/dbget-bin/www_bget?ko:K14289 Q9HAV4 1527 8.6e-168 Exportin-5 OS=Homo sapiens GN=XPO5 PE=1 SV=1 PF05236//PF00822//PF03810 Transcription initiation factor TFIID component TAF4 family//PMP-22/EMP/MP20/Claudin family//Importin-beta N-terminal domain GO:0006352//GO:0006886 DNA-templated transcription, initiation//intracellular protein transport GO:0008536 Ran GTPase binding GO:0005669//GO:0016021 transcription factor TFIID complex//integral component of membrane KOG2020 Nuclear transport receptor CRM1/MSN5 (importin beta superfamily) Cluster-8309.52295 BF_2 639.95 3.47 7994 478259801 ENN79629.1 3189 0.0e+00 hypothetical protein YQE_03918, partial [Dendroctonus ponderosae] 642912170 XM_008202615.1 170 1.14606e-80 PREDICTED: Tribolium castaneum aminopeptidase N-like (LOC657312), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15144 1536 1.7e-168 Aminopeptidase N OS=Homo sapiens GN=ANPEP PE=1 SV=4 PF01433//PF00443 Peptidase family M1//Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459//GO:0008270//GO:0008237 ubiquitinyl hydrolase activity//zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.52297 BF_2 53.18 0.97 2591 642919246 XP_008191792.1 872 1.3e-90 PREDICTED: rhabdoid tumor deletion region protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ7 509 6.6e-50 Lysoplasmalogenase-like protein TMEM86A OS=Bos taurus GN=TMEM86A PE=2 SV=1 PF07947 YhhN-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.52298 BF_2 172.30 2.25 3493 546685251 ERL94778.1 1443 1.1e-156 hypothetical protein D910_12052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2Q2 261 5.1e-21 FERM domain-containing protein 4A OS=Homo sapiens GN=FRMD4A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52299 BF_2 34.89 0.67 2478 91088919 XP_973208.1 1960 8.5e-217 PREDICTED: protein asunder [Tribolium castaneum]>gi|270012357|gb|EFA08805.1| hypothetical protein TcasGA2_TC006499 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8QZV7 1003 3.3e-107 Protein asunder homolog OS=Mus musculus GN=Asun PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3711 Uncharacterized conserved protein Cluster-8309.5230 BF_2 10.63 0.56 1088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52302 BF_2 91.00 4.93 1059 270001219 EEZ97666.1 754 2.6e-77 hypothetical protein TcasGA2_TC016211 [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q9FN05 368 6.0e-34 Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.52304 BF_2 258.98 2.69 4313 642923817 XP_001816010.2 2807 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase CYLD [Tribolium castaneum] 642923816 XM_001815958.2 225 1.64211e-111 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase CYLD (LOC663788), mRNA K08601 CYLD, USLP2 ubiquitin thioesterase CYLD http://www.genome.jp/dbget-bin/www_bget?ko:K08601 Q9NQC7 1004 4.4e-107 Ubiquitin carboxyl-terminal hydrolase CYLD OS=Homo sapiens GN=CYLD PE=1 SV=1 PF00443//PF07297//PF04451//PF01529 Ubiquitin carboxyl-terminal hydrolase//Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)//Large eukaryotic DNA virus major capsid protein//DHHC palmitoyltransferase GO:0009059//GO:0016579 macromolecule biosynthetic process//protein deubiquitination GO:0008270//GO:0036459//GO:0005198 zinc ion binding//ubiquitinyl hydrolase activity//structural molecule activity GO:0019028//GO:0030176 viral capsid//integral component of endoplasmic reticulum membrane KOG2257 N-acetylglucosaminyltransferase complex, subunit PIG-P, required for phosphatidylinositol biosynthesis Cluster-8309.52305 BF_2 479.00 762.71 295 743741691 XP_010965357.1 516 2.8e-50 PREDICTED: uncharacterized protein LOC105078493 [Camelus bactrianus] 17932987 AB061847.1 283 5.76702e-145 Homo sapiens RPS29 gene for ribosomal protein S29, complete cds and sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52309 BF_2 10.65 0.81 839 642912070 XP_008200786.1 442 3.0e-41 PREDICTED: peroxidase isoform X2 [Tribolium castaneum]>gi|642912072|ref|XP_008200787.1| PREDICTED: peroxidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q01603 262 9.3e-22 Peroxidase OS=Drosophila melanogaster GN=Pxd PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2408 Peroxidase/oxygenase Cluster-8309.52310 BF_2 9.00 2.17 460 189241705 XP_967022.2 360 5.4e-32 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K12317 GANC neutral alpha-glucosidase C http://www.genome.jp/dbget-bin/www_bget?ko:K12317 Q8BVW0 328 1.1e-29 Neutral alpha-glucosidase C OS=Mus musculus GN=Ganc PE=2 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.52311 BF_2 117.09 1.93 2831 189241705 XP_967022.2 1414 2.0e-153 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q94502 973 1.1e-103 Neutral alpha-glucosidase AB OS=Dictyostelium discoideum GN=modA PE=3 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.52313 BF_2 325.13 4.88 3073 642926822 XP_008195028.1 2091 6.8e-232 PREDICTED: pre-mRNA-processing factor 40 homolog A [Tribolium castaneum]>gi|270009175|gb|EFA05623.1| hypothetical protein TcasGA2_TC015831 [Tribolium castaneum] 642926821 XM_008196806.1 308 8.45791e-158 PREDICTED: Tribolium castaneum pre-mRNA-processing factor 40 homolog A (LOC658510), mRNA K12821 PRPF40, PRP40 pre-mRNA-processing factor 40 http://www.genome.jp/dbget-bin/www_bget?ko:K12821 Q6NWY9 1231 1.5e-133 Pre-mRNA-processing factor 40 homolog B OS=Homo sapiens GN=PRPF40B PE=1 SV=1 PF00397 WW domain -- -- GO:0005515 protein binding -- -- KOG0152 Spliceosomal protein FBP11/Splicing factor PRP40 Cluster-8309.52316 BF_2 8.00 0.72 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52318 BF_2 39.00 3.06 820 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52320 BF_2 1.00 1.26 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52321 BF_2 8.55 0.85 707 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52323 BF_2 33.05 1.42 1258 780633762 XP_011686120.1 143 2.1e-06 PREDICTED: uncharacterized protein LOC105448935 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52324 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52325 BF_2 1.00 2.16 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52327 BF_2 1.00 4.65 255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52328 BF_2 6.00 0.31 1096 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52332 BF_2 269.36 9.18 1515 642926073 XP_008194754.1 280 3.3e-22 PREDICTED: E3 ubiquitin-protein ligase RNF8-B-like [Tribolium castaneum]>gi|270008553|gb|EFA05001.1| hypothetical protein TcasGA2_TC015080 [Tribolium castaneum] -- -- -- -- -- K10667 RNF8 E3 ubiquitin-protein ligase RNF8 http://www.genome.jp/dbget-bin/www_bget?ko:K10667 Q2HJ46 264 9.9e-22 E3 ubiquitin-protein ligase RNF8 OS=Bos taurus GN=RNF8 PE=2 SV=1 PF04564//PF14634//PF12678//PF00498//PF00097//PF16685//PF13639//PF12861 U-box domain//zinc-RING finger domain//RING-H2 zinc finger//FHA domain//Zinc finger, C3HC4 type (RING finger)//zinc RING finger of MSL2//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0061630//GO:0004842//GO:0005515//GO:0008270//GO:0043169//GO:0046872 ubiquitin protein ligase activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//cation binding//metal ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.52333 BF_2 20.94 0.60 1753 765160702 XP_011489848.1 269 7.3e-21 PREDICTED: E3 ubiquitin-protein ligase RNF8 isoform X4 [Oryzias latipes] -- -- -- -- -- K10667 RNF8 E3 ubiquitin-protein ligase RNF8 http://www.genome.jp/dbget-bin/www_bget?ko:K10667 Q2HJ46 261 2.5e-21 E3 ubiquitin-protein ligase RNF8 OS=Bos taurus GN=RNF8 PE=2 SV=1 PF13639//PF16685//PF12861//PF00097//PF00498//PF12678//PF17123//PF04564//PF14634 Ring finger domain//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc finger, C3HC4 type (RING finger)//FHA domain//RING-H2 zinc finger//RING-like zinc finger//U-box domain//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0004842//GO:0061630//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//ubiquitin protein ligase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.52334 BF_2 4.00 0.70 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52335 BF_2 27.60 5.72 489 546678005 ERL88729.1 701 1.6e-71 hypothetical protein D910_06111 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9UKZ1 617 3.7e-63 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52336 BF_2 6.00 0.35 1009 861611173 KMQ85248.1 738 1.7e-75 nuclease harbi1 [Lasius niger] -- -- -- -- -- -- -- -- -- Q96MB7 332 8.6e-30 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF01609//PF04827 Transposase DDE domain//Plant transposon protein GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.52338 BF_2 83.00 1.81 2201 -- -- -- -- -- 642913296 XM_970406.2 58 5.68653e-19 PREDICTED: Tribolium castaneum vesicular acetylcholine transporter (LOC664399), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52344 BF_2 457.00 3.71 5445 642919210 XP_008191781.1 5464 0.0e+00 PREDICTED: uncharacterized protein LOC657327 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00530//PF15494//PF09272 Scavenger receptor cysteine-rich domain//Scavenger receptor cysteine-rich domain//Hepsin, SRCR GO:0007165 signal transduction GO:0004252//GO:0070008//GO:0005044 serine-type endopeptidase activity//serine-type exopeptidase activity//scavenger receptor activity GO:0016020 membrane -- -- Cluster-8309.52345 BF_2 57.08 0.69 3726 642923662 XP_008193832.1 4111 0.0e+00 PREDICTED: protein phosphatase PHLPP-like protein [Tribolium castaneum] 642923661 XM_008195610.1 421 0 PREDICTED: Tribolium castaneum protein phosphatase PHLPP-like protein (LOC662191), mRNA K16340 PHLPP PH domain and leucine-rich repeat-containing protein phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16340 Q9VJ07 1138 1.1e-122 Protein phosphatase PHLPP-like protein OS=Drosophila melanogaster GN=Phlpp PE=3 SV=1 PF00560//PF00481//PF13855 Leucine Rich Repeat//Protein phosphatase 2C//Leucine rich repeat -- -- GO:0003824//GO:0005515 catalytic activity//protein binding -- -- KOG0618 Serine/threonine phosphatase 2C containing leucine-rich repeats, similar to SCN circadian oscillatory protein (SCOP) Cluster-8309.52346 BF_2 103.92 1.27 3710 642923662 XP_008193832.1 4367 0.0e+00 PREDICTED: protein phosphatase PHLPP-like protein [Tribolium castaneum] 642923661 XM_008195610.1 432 0 PREDICTED: Tribolium castaneum protein phosphatase PHLPP-like protein (LOC662191), mRNA K16340 PHLPP PH domain and leucine-rich repeat-containing protein phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K16340 Q9VJ07 1138 1.1e-122 Protein phosphatase PHLPP-like protein OS=Drosophila melanogaster GN=Phlpp PE=3 SV=1 PF00481//PF00560//PF13855 Protein phosphatase 2C//Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515//GO:0003824 protein binding//catalytic activity -- -- KOG0618 Serine/threonine phosphatase 2C containing leucine-rich repeats, similar to SCN circadian oscillatory protein (SCOP) Cluster-8309.52347 BF_2 45.81 1.22 1860 546686189 ERL95569.1 1395 2.1e-151 hypothetical protein D910_12830 [Dendroctonus ponderosae] -- -- -- -- -- K09881 AGK acylglycerol kinase http://www.genome.jp/dbget-bin/www_bget?ko:K09881 Q53H12 619 8.3e-63 Acylglycerol kinase, mitochondrial OS=Homo sapiens GN=AGK PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain -- -- GO:0016301 kinase activity -- -- KOG4435 Predicted lipid kinase Cluster-8309.52348 BF_2 17.18 0.42 1984 642912369 XP_008199613.1 346 9.8e-30 PREDICTED: diuretic hormone class 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLK4 172 6.0e-11 Diuretic hormone class 2 OS=Drosophila melanogaster GN=Dh31 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5235 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05112 Baculovirus P47 protein GO:0046782 regulation of viral transcription -- -- -- -- -- -- Cluster-8309.52351 BF_2 189.00 13.07 892 270002929 EEZ99376.1 680 8.1e-69 serine protease P24 [Tribolium castaneum] -- -- -- -- -- K08665 HPN hepsin http://www.genome.jp/dbget-bin/www_bget?ko:K08665 P35037 542 3.4e-54 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52352 BF_2 128.70 5.83 1210 332375232 AEE62757.1 903 1.5e-94 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00729 ALG5 dolichyl-phosphate beta-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00729 Q9VLQ1 711 1.2e-73 Dolichyl-phosphate beta-glucosyltransferase OS=Drosophila melanogaster GN=wol PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2977 Glycosyltransferase Cluster-8309.52353 BF_2 44.34 0.46 4302 688550711 XP_009299041.1 812 1.9e-83 PREDICTED: gastrula zinc finger protein XlCGF57.1-like, partial [Danio rerio] -- -- -- -- -- -- -- -- -- P52742 790 2.9e-82 Zinc finger protein 135 OS=Homo sapiens GN=ZNF135 PE=2 SV=3 PF00096//PF02178//PF13465//PF07776//PF16622//PF13912 Zinc finger, C2H2 type//AT hook motif//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0008270//GO:0003677//GO:0046872 zinc ion binding//DNA binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.52355 BF_2 1277.65 27.96 2199 741829513 AJA91072.1 1659 6.1e-182 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 1063 3.2e-114 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067//PF15681//PF09298 Cytochrome P450//Lymphocyte activation family X//Fumarylacetoacetase N-terminal GO:0006570//GO:0055114//GO:0042207//GO:0006955//GO:0051249//GO:0009072 tyrosine metabolic process//oxidation-reduction process//styrene catabolic process//immune response//regulation of lymphocyte activation//aromatic amino acid family metabolic process GO:0016705//GO:0004334//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//fumarylacetoacetase activity//iron ion binding//heme binding -- -- -- -- Cluster-8309.52356 BF_2 82.57 0.85 4344 91078420 XP_974692.1 1424 2.1e-154 PREDICTED: tektin-3 [Tribolium castaneum]>gi|270003874|gb|EFA00322.1| hypothetical protein TcasGA2_TC003160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16T79 1220 4.0e-132 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Aedes aegypti GN=AAEL010360 PE=3 SV=2 PF00005//PF03193//PF07989//PF03938//PF08653//PF08912//PF08702//PF01583//PF16331//PF00437//PF01920//PF01544//PF10018//PF09177//PF06414//PF00931//PF03255//PF07728//PF03082//PF02951//PF16716 ABC transporter//Protein of unknown function, DUF258//Centrosomin N-terminal motif 1//Outer membrane protein (OmpH-like)//DASH complex subunit Dam1//Rho Binding//Fibrinogen alpha/beta chain family//Adenylylsulphate kinase//TolA binding protein trimerisation//Type II/IV secretion system protein//Prefoldin subunit//CorA-like Mg2+ transporter protein//Vitamin-D-receptor interacting Mediator subunit 4//Syntaxin 6, N-terminal//Zeta toxin//NB-ARC domain//Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit//AAA domain (dynein-related subfamily)//Male accessory gland secretory protein//Prokaryotic glutathione synthetase, N-terminal domain//Bone marrow stromal antigen 2 GO:0006750//GO:0006090//GO:0008608//GO:0006357//GO:0055085//GO:0030168//GO:0000103//GO:0048193//GO:0006633//GO:0070206//GO:0006810//GO:0051258//GO:0007165//GO:0000226//GO:0007618//GO:0006144//GO:0051607//GO:0006457//GO:0030001 glutathione biosynthetic process//pyruvate metabolic process//attachment of spindle microtubules to kinetochore//regulation of transcription from RNA polymerase II promoter//transmembrane transport//platelet activation//sulfate assimilation//Golgi vesicle transport//fatty acid biosynthetic process//protein trimerization//transport//protein polymerization//signal transduction//microtubule cytoskeleton organization//mating//purine nucleobase metabolic process//defense response to virus//protein folding//metal ion transport GO:0005102//GO:0016887//GO:0016301//GO:0051082//GO:0003924//GO:0005524//GO:0017048//GO:0003989//GO:0046873//GO:0030674//GO:0001104//GO:0004363//GO:0005525//GO:0004020//GO:0043531 receptor binding//ATPase activity//kinase activity//unfolded protein binding//GTPase activity//ATP binding//Rho GTPase binding//acetyl-CoA carboxylase activity//metal ion transmembrane transporter activity//protein binding, bridging//RNA polymerase II transcription cofactor activity//glutathione synthase activity//GTP binding//adenylylsulfate kinase activity//ADP binding GO:0005577//GO:0016272//GO:0072686//GO:0016592//GO:0009317//GO:0042729//GO:0005815//GO:0016020//GO:0005576//GO:0005874 fibrinogen complex//prefoldin complex//mitotic spindle//mediator complex//acetyl-CoA carboxylase complex//DASH complex//microtubule organizing center//membrane//extracellular region//microtubule KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.52358 BF_2 3.00 0.70 466 642937507 XP_008198870.1 220 9.3e-16 PREDICTED: protein tramtrack, beta isoform-like isoform X30 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52360 BF_2 50.80 1.64 1580 91079782 XP_967732.1 789 3.3e-81 PREDICTED: 39S ribosomal protein L38, mitochondrial [Tribolium castaneum]>gi|270003311|gb|EEZ99758.1| hypothetical protein TcasGA2_TC002530 [Tribolium castaneum] 170048742 XM_001870724.1 54 6.78742e-17 Culex quinquefasciatus mitochondrial ribosomal protein L38, mRNA K17419 MRPL38 large subunit ribosomal protein L38 http://www.genome.jp/dbget-bin/www_bget?ko:K17419 Q3ZBF3 401 1.3e-37 39S ribosomal protein L38, mitochondrial OS=Bos taurus GN=MRPL38 PE=1 SV=2 PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion KOG3346 Phosphatidylethanolamine binding protein Cluster-8309.52361 BF_2 1.00 0.35 404 357622556 EHJ73984.1 218 1.4e-15 eIF2B-alpha protein [Danaus plexippus] -- -- -- -- -- K03239 EIF2B1 translation initiation factor eIF-2B subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03239 Q99LC8 184 5.0e-13 Translation initiation factor eIF-2B subunit alpha OS=Mus musculus GN=Eif2b1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1466 Translation initiation factor 2B, alpha subunit (eIF-2Balpha/GCN3) Cluster-8309.52362 BF_2 33.45 0.43 3525 642921224 XP_008192769.1 1907 1.7e-210 PREDICTED: apoptosis-stimulating of p53 protein 1 isoform X1 [Tribolium castaneum] 642921235 XM_008194553.1 272 9.9956e-138 PREDICTED: Tribolium castaneum apoptosis-stimulating of p53 protein 1 (LOC657019), transcript variant X7, mRNA K17554 PPP1R13B, ASPP1 apoptosis-stimulating of p53 protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17554 Q8CG79 651 3.1e-66 Apoptosis-stimulating of p53 protein 2 OS=Mus musculus GN=Tp53bp2 PE=1 SV=3 PF00018//PF14604//PF00023//PF13606//PF00788 SH3 domain//Variant SH3 domain//Ankyrin repeat//Ankyrin repeat//Ras association (RalGDS/AF-6) domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG0515 p53-interacting protein 53BP/ASPP, contains ankyrin and SH3 domains Cluster-8309.52363 BF_2 65.74 5.51 786 759035214 XP_011338260.1 142 1.7e-06 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105279872 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52364 BF_2 33.68 1.98 1000 755948394 XP_011300766.1 1018 5.9e-108 PREDICTED: ryanodine receptor 44F isoform X9 [Fopius arisanus] 194752972 XM_001958757.1 275 5.95205e-140 Drosophila ananassae GF12384 (Dana\GF12384), mRNA K04962 RYR2 ryanodine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04962 Q24498 1016 4.1e-109 Ryanodine receptor 44F OS=Drosophila melanogaster GN=Rya-r44F PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2243 Ca2+ release channel (ryanodine receptor) Cluster-8309.52365 BF_2 134.40 1.75 3503 411147305 BAM66322.1 2031 7.1e-225 GABA-gated chloride channel [Oulema oryzae] 584463066 KC288141.2 762 0 Diabrotica virgifera virgifera GABA receptor mRNA, complete cds K05195 GLRA3 glycine receptor alpha-3 http://www.genome.jp/dbget-bin/www_bget?ko:K05195 Q75NA5 1805 4.7e-200 Gamma-aminobutyric acid receptor subunit beta OS=Musca domestica GN=Rdl PE=1 SV=2 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3643 GABA receptor Cluster-8309.52366 BF_2 85.43 1.50 2676 300807184 NP_001180223.1 1572 9.1e-172 juvenile hormone esterase precursor [Tribolium castaneum]>gi|300117035|dbj|BAJ10675.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117037|dbj|BAJ10676.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117039|dbj|BAJ10677.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117041|dbj|BAJ10678.1| juvenile hormone esterase [Tribolium castaneum]>gi|300117043|dbj|BAJ10679.1| juvenile hormone esterase [Tribolium castaneum] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 B2D0J5 712 2.0e-73 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.52367 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52373 BF_2 60.46 5.62 737 91090888 XP_973381.1 1122 3.8e-120 PREDICTED: YEATS domain-containing protein 4 [Tribolium castaneum]>gi|270014003|gb|EFA10451.1| hypothetical protein TcasGA2_TC012697 [Tribolium castaneum] 571562276 XM_396159.3 137 2.2409e-63 PREDICTED: Apis mellifera YEATS domain-containing protein 4 (Gas41), transcript variant X2, mRNA K11341 YEATS4, GAS41, YAF9 YEATS domain-containing protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11341 O95619 762 8.6e-80 YEATS domain-containing protein 4 OS=Homo sapiens GN=YEATS4 PE=1 SV=1 PF03366//PF07544 YEATS family//RNA polymerase II transcription mediator complex subunit 9 GO:0006357//GO:0006355 regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated GO:0001104 RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592 nucleus//mediator complex KOG3149 Transcription initiation factor IIF, auxiliary subunit Cluster-8309.52376 BF_2 75.15 0.57 5777 780665970 XP_011694053.1 2073 1.6e-229 PREDICTED: uncharacterized protein LOC105453629 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06058//PF00665 Dcp1-like decapping family//Integrase core domain GO:0000290//GO:0043085//GO:0015074 deadenylation-dependent decapping of nuclear-transcribed mRNA//positive regulation of catalytic activity//DNA integration GO:0008047 enzyme activator activity -- -- -- -- Cluster-8309.52377 BF_2 28.45 0.63 2167 642922696 XP_008193284.1 873 8.3e-91 PREDICTED: succinate--hydroxymethylglutarate CoA-transferase [Tribolium castaneum] -- -- -- -- -- K18703 SUGCT succinate---hydroxymethylglutarate CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18703 Q7TNE1 620 7.4e-63 Succinate--hydroxymethylglutarate CoA-transferase OS=Mus musculus GN=Sugct PE=1 SV=2 PF02515 CoA-transferase family III -- -- GO:0003824 catalytic activity -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.52378 BF_2 96.69 2.29 2053 642922696 XP_008193284.1 1638 1.5e-179 PREDICTED: succinate--hydroxymethylglutarate CoA-transferase [Tribolium castaneum] -- -- -- -- -- K18703 SUGCT succinate---hydroxymethylglutarate CoA-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K18703 Q7TNE1 1143 1.6e-123 Succinate--hydroxymethylglutarate CoA-transferase OS=Mus musculus GN=Sugct PE=1 SV=2 PF02515 CoA-transferase family III -- -- GO:0003824 catalytic activity -- -- KOG3957 Predicted L-carnitine dehydratase/alpha-methylacyl-CoA racemase Cluster-8309.52381 BF_2 393.54 4.95 3612 546674389 ERL85776.1 3682 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 491 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 6.0e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.52382 BF_2 72.21 0.53 6005 270014464 EFA10912.1 1704 1.0e-186 hypothetical protein TcasGA2_TC001738 [Tribolium castaneum] 805771594 XM_012281304.1 194 3.91715e-94 PREDICTED: Megachile rotundata casein kinase I isoform gamma-3 (LOC100876501), transcript variant X5, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q62763 1402 4.3e-153 Casein kinase I isoform gamma-3 OS=Rattus norvegicus GN=Csnk1g3 PE=2 SV=1 PF02184//PF00069//PF07714//PF12605 HAT (Half-A-TPR) repeat//Protein kinase domain//Protein tyrosine kinase//Casein kinase 1 gamma C terminal GO:0009069//GO:0006468//GO:0016310//GO:0006396 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//RNA processing GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity GO:0005622 intracellular KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.52385 BF_2 916.40 10.31 4007 642911919 XP_008199022.1 2018 2.6e-223 PREDICTED: casein kinase I isoform gamma-3-like isoform X2 [Tribolium castaneum] 805771594 XM_012281304.1 194 2.60597e-94 PREDICTED: Megachile rotundata casein kinase I isoform gamma-3 (LOC100876501), transcript variant X5, mRNA K08958 CSNK1G casein kinase 1, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08958 Q62763 1546 5.8e-170 Casein kinase I isoform gamma-3 OS=Rattus norvegicus GN=Csnk1g3 PE=2 SV=1 PF00069//PF02184//PF07714//PF12605 Protein kinase domain//HAT (Half-A-TPR) repeat//Protein tyrosine kinase//Casein kinase 1 gamma C terminal GO:0006396//GO:0016310//GO:0009069//GO:0006468 RNA processing//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding GO:0005622 intracellular KOG1165 Casein kinase (serine/threonine/tyrosine protein kinase) Cluster-8309.52386 BF_2 3868.09 212.96 1047 573908188 XP_006641813.1 816 1.6e-84 PREDICTED: cathepsin S-like isoform X1 [Lepisosteus oculatus] -- -- -- -- -- K01368 CTSS cathepsin S http://www.genome.jp/dbget-bin/www_bget?ko:K01368 Q86GF7 792 4.1e-83 Crustapain OS=Pandalus borealis GN=Cys PE=1 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.52388 BF_2 486.87 5.68 3874 -- -- -- -- -- 301173032 NR_036303.1 37 4.75327e-07 Tribolium castaneum microRNA mir-277 (Mir277), microRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52390 BF_2 3.00 7.56 276 728418241 AIY68362.1 156 1.4e-08 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52391 BF_2 37.00 0.53 3218 728417333 AIY68340.1 483 2.1e-45 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P35502 315 2.6e-27 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.52393 BF_2 200.20 64.59 416 728418241 AIY68362.1 252 1.6e-19 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09392 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF GO:0009405//GO:0015031 pathogenesis//protein transport -- -- -- -- -- -- Cluster-8309.52394 BF_2 71.38 1.85 1901 728418241 AIY68362.1 1155 1.5e-123 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 482 6.5e-47 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.52395 BF_2 73.92 2.31 1623 728418241 AIY68362.1 1052 1.1e-111 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 P47982 522 1.3e-51 Esterase 6 OS=Drosophila mauritiana GN=Est-6 PE=3 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.52396 BF_2 712.93 9.91 3296 642928315 XP_008195531.1 965 2.7e-101 PREDICTED: microtubule-associated protein RP/EB family member 1 [Tribolium castaneum] 389608702 AK401339.1 148 7.9716e-69 Papilio xuthus mRNA for microtubule binding protein, putative, complete cds, sequence id: Px-0417 K10436 MAPRE microtubule-associated protein, RP/EB family http://www.genome.jp/dbget-bin/www_bget?ko:K10436 Q6P848 756 1.9e-78 Microtubule-associated protein RP/EB family member 1 OS=Xenopus tropicalis GN=mapre1 PE=2 SV=1 PF06070//PF00307//PF03271//PF05361 Herpesvirus large structural phosphoprotein UL32//Calponin homology (CH) domain//EB1-like C-terminal motif//PKC-activated protein phosphatase-1 inhibitor GO:0042325 regulation of phosphorylation GO:0005198//GO:0005515//GO:0008017 structural molecule activity//protein binding//microtubule binding GO:0005737//GO:0045298 cytoplasm//tubulin complex KOG3000 Microtubule-binding protein involved in cell cycle control Cluster-8309.52398 BF_2 14.69 0.68 1188 194754345 XP_001959456.1 143 2.0e-06 GF12046 [Drosophila ananassae]>gi|190620754|gb|EDV36278.1| GF12046 [Drosophila ananassae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04487//PF01155 CITED//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006355//GO:0006464 regulation of transcription, DNA-templated//cellular protein modification process GO:0016151 nickel cation binding GO:0005634 nucleus -- -- Cluster-8309.52402 BF_2 198.73 1.92 4615 642923551 XP_008193555.1 837 2.6e-86 PREDICTED: Golgi integral membrane protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 186 3.3e-12 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 PF05090//PF04111//PF02566//PF01940//PF02513 Vitamin K-dependent gamma-carboxylase//Autophagy protein Apg6//OsmC-like protein//Integral membrane protein DUF92//Spin/Ssty Family GO:0007276//GO:0006979//GO:0017187//GO:0006914 gamete generation//response to oxidative stress//peptidyl-glutamic acid carboxylation//autophagy GO:0008488 gamma-glutamyl carboxylase activity GO:0016021 integral component of membrane -- -- Cluster-8309.52404 BF_2 29.59 7.97 442 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52405 BF_2 724.68 6.12 5238 642928819 XP_008195574.1 1389 2.9e-150 PREDICTED: transcriptional repressor p66-alpha isoform X1 [Tribolium castaneum] 642928820 XM_008197353.1 64 6.30726e-22 PREDICTED: Tribolium castaneum transcriptional repressor p66-alpha (LOC656529), transcript variant X2, mRNA -- -- -- -- Q8VHR5 344 1.8e-30 Transcriptional repressor p66-beta OS=Mus musculus GN=Gatad2b PE=1 SV=1 PF00320 GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.52407 BF_2 108.02 3.15 1724 642936590 XP_008198497.1 809 1.7e-83 PREDICTED: uncharacterized protein LOC103314369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52409 BF_2 19.87 0.59 1690 642923832 XP_008193898.1 2202 5.1e-245 PREDICTED: importin subunit alpha-4 [Tribolium castaneum] 170029938 XM_001842796.1 194 1.08643e-94 Culex quinquefasciatus importin alpha, mRNA -- -- -- -- O35343 1804 2.9e-200 Importin subunit alpha-3 OS=Mus musculus GN=Kpna4 PE=1 SV=1 PF01749//PF02985//PF01602//PF11698//PF00514 Importin beta binding domain//HEAT repeat//Adaptin N terminal region//V-ATPase subunit H//Armadillo/beta-catenin-like repeat GO:0015031//GO:0006606//GO:0016192//GO:0006886//GO:0015991 protein transport//protein import into nucleus//vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport GO:0008565//GO:0005515//GO:0016820 protein transporter activity//protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0030117//GO:0005737//GO:0000221//GO:0005634 membrane coat//cytoplasm//vacuolar proton-transporting V-type ATPase, V1 domain//nucleus KOG0166 Karyopherin (importin) alpha Cluster-8309.52411 BF_2 164.00 9.15 1037 478257192 ENN77355.1 185 2.4e-11 hypothetical protein YQE_06180, partial [Dendroctonus ponderosae]>gi|546681401|gb|ERL91498.1| hypothetical protein D910_08828 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52412 BF_2 4.00 0.98 458 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52415 BF_2 13.55 0.40 1701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52416 BF_2 48.67 0.42 5083 817074162 XP_012259260.1 369 5.4e-32 PREDICTED: uncharacterized protein LOC105687895 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52420 BF_2 316.98 1.51 9063 270015570 EFA12018.1 4146 0.0e+00 hypothetical protein TcasGA2_TC001433 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86YS7 1257 4.2e-136 C2 domain-containing protein 5 OS=Homo sapiens GN=C2CD5 PE=1 SV=1 PF00168//PF08354 C2 domain//Domain of unknown function (DUF1729) GO:0042967//GO:0055114//GO:0006633 acyl-carrier-protein biosynthetic process//oxidation-reduction process//fatty acid biosynthetic process GO:0005515//GO:0004318 protein binding//enoyl-[acyl-carrier-protein] reductase (NADH) activity GO:0005835 fatty acid synthase complex KOG1031 Predicted Ca2+-dependent phospholipid-binding protein Cluster-8309.52423 BF_2 1.00 0.60 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52424 BF_2 57.89 1.63 1775 478256893 ENN77062.1 359 2.7e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 2.8e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF13912//PF07975//PF00096//PF13465 C2H2-type zinc finger//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.52428 BF_2 133.19 1.79 3398 189233571 XP_967872.2 671 3.4e-67 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96B67 190 8.4e-13 Arrestin domain-containing protein 3 OS=Homo sapiens GN=ARRDC3 PE=1 SV=1 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0051287 NAD binding -- -- -- -- Cluster-8309.52430 BF_2 112.51 0.86 5734 189233571 XP_967872.2 668 1.3e-66 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96B67 193 6.4e-13 Arrestin domain-containing protein 3 OS=Homo sapiens GN=ARRDC3 PE=1 SV=1 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0051287 NAD binding -- -- -- -- Cluster-8309.52435 BF_2 26.36 1.22 1194 546676040 ERL87123.1 220 2.4e-15 hypothetical protein D910_04523 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52438 BF_2 49.64 0.48 4571 270011590 EFA08038.1 2616 1.3e-292 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ET47 434 5.8e-41 Espin OS=Mus musculus GN=Espn PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52439 BF_2 137.96 3.20 2093 642914172 XP_008201574.1 1882 8.0e-208 PREDICTED: KAT8 regulatory NSL complex subunit 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- K16719 KANSL3, RCD1 regulatory NSL complex subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K16719 A2RSY1 954 1.3e-101 KAT8 regulatory NSL complex subunit 3 OS=Mus musculus GN=Kansl3 PE=2 SV=1 PF01738 Dienelactone hydrolase family -- -- GO:0016787 hydrolase activity -- -- KOG3253 Predicted alpha/beta hydrolase Cluster-8309.52441 BF_2 12.00 181.74 223 728418241 AIY68362.1 287 7.6e-24 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 B2D0J5 241 6.7e-20 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.52447 BF_2 16.00 1.43 754 746849727 XP_011055317.1 270 2.4e-21 PREDICTED: uncharacterized protein LOC105146626 isoform X1 [Acromyrmex echinatior]>gi|746849729|ref|XP_011055318.1| PREDICTED: uncharacterized protein LOC105146626 isoform X2 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52448 BF_2 12.00 0.51 1262 847114225 XP_012815396.1 145 1.3e-06 PREDICTED: uncharacterized protein LOC105946840 [Xenopus (Silurana) tropicalis]>gi|847114228|ref|XP_012815397.1| PREDICTED: uncharacterized protein LOC105946840 [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07850//PF04218 Renin receptor-like protein//CENP-B N-terminal DNA-binding domain GO:0007165 signal transduction GO:0004872//GO:0003677 receptor activity//DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.52449 BF_2 53.65 1.18 2184 546677792 ERL88559.1 1875 5.4e-207 hypothetical protein D910_05944 [Dendroctonus ponderosae] -- -- -- -- -- K13174 THOC5 THO complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13174 Q6NY52 901 1.9e-95 THO complex subunit 5 homolog OS=Danio rerio GN=thoc5 PE=2 SV=1 PF05225//PF05773 helix-turn-helix, Psq domain//RWD domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG2216 Conserved coiled/coiled coil protein Cluster-8309.52450 BF_2 16.00 0.73 1205 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52456 BF_2 90.52 0.37 10407 642914926 XP_008190444.1 6829 0.0e+00 PREDICTED: protein slit isoform X1 [Tribolium castaneum] 462424845 APGK01016975.1 99 4.39461e-41 Dendroctonus ponderosae Seq01016985, whole genome shotgun sequence K06839 SLIT2 slit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06839 P24014 5191 0.0e+00 Protein slit OS=Drosophila melanogaster GN=sli PE=1 SV=2 PF07645//PF00008//PF14634//PF00560//PF00097//PF13639//PF13855 Calcium-binding EGF domain//EGF-like domain//zinc-RING finger domain//Leucine Rich Repeat//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Leucine rich repeat -- -- GO:0005515//GO:0046872//GO:0008270//GO:0005509 protein binding//metal ion binding//zinc ion binding//calcium ion binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.52463 BF_2 23.87 0.67 1768 645020639 XP_008207241.1 193 4.8e-12 PREDICTED: uncharacterized protein LOC100678007 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04998 RNA polymerase Rpb1, domain 5 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.52469 BF_2 19.22 0.32 2779 642929061 XP_008195675.1 998 3.4e-105 PREDICTED: metastasis suppressor protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205//PF14980 WH2 motif//TIP39 peptide GO:0007218 neuropeptide signaling pathway GO:0003779 actin binding GO:0005576 extracellular region -- -- Cluster-8309.52473 BF_2 14.00 3.02 481 270003964 EFA00412.1 182 2.5e-11 hypothetical protein TcasGA2_TC003263 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF00097//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.52474 BF_2 459.41 5.96 3509 642915289 XP_975869.2 2037 1.4e-225 PREDICTED: RING finger and SPRY domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5R881 1386 1.8e-151 RING finger and SPRY domain-containing protein 1 OS=Pongo abelii GN=RSPRY1 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2242 Scaffold/matrix specific factor hnRNP-U/SAF-A, contains SPRY domain Cluster-8309.52483 BF_2 24.22 0.54 2147 34099638 AAQ57129.1 1222 2.8e-131 endonuclease and reverse transcriptase-like protein [Bombyx mori] 347439535 JN415099.1 335 5.76011e-173 Scylla paramamosain clone QX04 microsatellite sequence -- -- -- -- Q95SX7 373 3.2e-34 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0008168//GO:0016706 methyltransferase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.52486 BF_2 3.00 0.44 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52489 BF_2 896.74 20.01 2162 189235467 XP_001814003.1 660 4.1e-66 PREDICTED: chymotrypsin-1 [Tribolium castaneum]>gi|270004829|gb|EFA01277.1| serine protease P40 [Tribolium castaneum] -- -- -- -- -- K09635 TMPRSS4 transmembrane protease, serine 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09635 Q7SIG2 428 1.4e-40 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.52502 BF_2 19.00 0.59 1637 642922824 XP_008193341.1 354 9.5e-31 PREDICTED: uncharacterized protein LOC103313006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04706//PF02172 Dickkopf N-terminal cysteine-rich region//KIX domain GO:0006355//GO:0007275//GO:0030178 regulation of transcription, DNA-templated//multicellular organismal development//negative regulation of Wnt signaling pathway GO:0003712 transcription cofactor activity GO:0005576//GO:0005667 extracellular region//transcription factor complex -- -- Cluster-8309.52503 BF_2 93.00 2.95 1607 -- -- -- -- -- 297598917 NM_001052974.2 1211 0 Oryza sativa Japonica Group Os02g0249600 (Os02g0249600) mRNA, complete cds -- -- -- -- Q02897 2104 4.6e-235 Glutelin type-B 2 OS=Oryza sativa subsp. japonica GN=GLUB2 PE=2 SV=2 PF00190//PF03079 Cupin//ARD/ARD' family GO:0055114 oxidation-reduction process GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity -- -- -- -- Cluster-8309.52505 BF_2 114.42 0.97 5204 641658099 XP_008180596.1 1075 7.5e-114 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 967 1.0e-102 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF13465//PF00096//PF16622//PF07776//PF00400//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//WD domain, G-beta repeat//C2H2-type zinc finger -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.52509 BF_2 128.32 2.94 2114 642919263 XP_008191800.1 2060 1.8e-228 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGM5 1006 1.3e-107 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.52510 BF_2 28.68 0.77 1844 642923490 XP_008193532.1 1769 8.9e-195 PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum]>gi|642923492|ref|XP_967512.2| PREDICTED: glycoprotein 3-alpha-L-fucosyltransferase A [Tribolium castaneum] 198474593 XM_002132688.1 75 1.68414e-28 Drosophila pseudoobscura pseudoobscura GA25723 (Dpse\GA25723), partial mRNA K00753 E2.4.1.214 glycoprotein 3-alpha-L-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00753 Q9VUL9 1234 4.0e-134 Glycoprotein 3-alpha-L-fucosyltransferase A OS=Drosophila melanogaster GN=FucTA PE=2 SV=2 PF00159//PF00228//PF00852 Pancreatic hormone peptide//Bowman-Birk serine protease inhibitor family//Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0007165//GO:0006486 signal transduction//protein glycosylation GO:0008417//GO:0005179//GO:0004867 fucosyltransferase activity//hormone activity//serine-type endopeptidase inhibitor activity GO:0016020//GO:0005576 membrane//extracellular region KOG2619 Fucosyltransferase Cluster-8309.52511 BF_2 83.00 3.21 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52513 BF_2 53.08 0.56 4243 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52518 BF_2 45.28 0.53 3871 577754852 AHH86055.1 1195 6.8e-128 glycoside hydrolase family 31 [Leptinotarsa decemlineata] -- -- -- -- -- K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 Q6NSJ0 469 4.3e-45 Uncharacterized family 31 glucosidase KIAA1161 OS=Homo sapiens GN=KIAA1161 PE=1 SV=2 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.52521 BF_2 26.40 0.55 2283 642917916 XP_008191381.1 886 2.7e-92 PREDICTED: methyltransferase-like protein 17, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U2U7 405 6.6e-38 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF12326//PF02285//PF09243 N-glycosylation protein//Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006412//GO:0006123//GO:0015992//GO:0034599 translation//mitochondrial electron transport, cytochrome c to oxygen//proton transport//cellular response to oxidative stress GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277//GO:0005789 respiratory chain complex IV//endoplasmic reticulum membrane KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.52524 BF_2 600.66 15.24 1936 728418241 AIY68362.1 1296 6.6e-140 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P12992 556 1.7e-55 Juvenile hormone esterase OS=Heliothis virescens PE=1 SV=2 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.52525 BF_2 84.74 1.22 3181 642910319 XP_969877.2 1984 1.8e-219 PREDICTED: uridine-cytidine kinase-like 1 [Tribolium castaneum] 602627952 XM_007420856.1 35 5.03851e-06 PREDICTED: Python bivittatus uridine-cytidine kinase-like 1-like (LOC103062425), mRNA K00876 udk, UCK uridine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00876 Q91YL3 1136 1.6e-122 Uridine-cytidine kinase-like 1 OS=Mus musculus GN=Uckl1 PE=2 SV=1 PF03205//PF07931//PF01121//PF06414//PF01583//PF00485//PF02224 Molybdopterin guanine dinucleotide synthesis protein B//Chloramphenicol phosphotransferase-like protein//Dephospho-CoA kinase//Zeta toxin//Adenylylsulphate kinase//Phosphoribulokinase / Uridine kinase family//Cytidylate kinase GO:0006144//GO:0000103//GO:0006139//GO:0008152//GO:0015940//GO:0015937//GO:0006777//GO:0006206 purine nucleobase metabolic process//sulfate assimilation//nucleobase-containing compound metabolic process//metabolic process//pantothenate biosynthetic process//coenzyme A biosynthetic process//Mo-molybdopterin cofactor biosynthetic process//pyrimidine nucleobase metabolic process GO:0004020//GO:0005524//GO:0016740//GO:0004140//GO:0005525//GO:0004127//GO:0016301 adenylylsulfate kinase activity//ATP binding//transferase activity//dephospho-CoA kinase activity//GTP binding//cytidylate kinase activity//kinase activity -- -- KOG4203 Armadillo/beta-Catenin/plakoglobin Cluster-8309.52527 BF_2 4.00 1.41 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5253 BF_2 68.11 1.74 1923 270009196 EFA05644.1 946 2.5e-99 hypothetical protein TcasGA2_TC015853 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q62052 560 6.0e-56 P protein OS=Mus musculus GN=Oca2 PE=1 SV=1 PF00957//PF03600//PF00939//PF00089 Synaptobrevin//Citrate transporter//Sodium:sulfate symporter transmembrane region//Trypsin GO:0006810//GO:0016192//GO:0055085//GO:0006508//GO:0006814 transport//vesicle-mediated transport//transmembrane transport//proteolysis//sodium ion transport GO:0005215//GO:0004252 transporter activity//serine-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.52531 BF_2 73.69 1.62 2189 642911136 XP_008200596.1 1379 1.8e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 7.0e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.52533 BF_2 578.26 9.44 2850 91086723 XP_970869.1 1296 9.7e-140 PREDICTED: zinc transporter foi [Tribolium castaneum]>gi|642928895|ref|XP_008195606.1| PREDICTED: zinc transporter foi [Tribolium castaneum] 847028608 KT163725.1 40 7.49068e-09 Schmidtea mediterranea slc39a-10 (slc39a-10) mRNA, complete cds K14716 SLC39A10, ZIP10 solute carrier family 39 (zinc transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K14716 Q9VSL7 697 1.1e-71 Zinc transporter foi OS=Drosophila melanogaster GN=foi PE=1 SV=3 PF02535 ZIP Zinc transporter GO:0055085//GO:0030001 transmembrane transport//metal ion transport GO:0046873 metal ion transmembrane transporter activity GO:0016020 membrane KOG2693 Putative zinc transporter Cluster-8309.52534 BF_2 124.46 3.28 1875 332373656 AEE61969.1 1637 1.8e-179 unknown [Dendroctonus ponderosae] 571430507 KF255600.1 387 0 Plutella xylostella protein phosphatase 4 mRNA, complete cds K15423 PPP4C serine/threonine-protein phosphatase 4 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K15423 Q5R6K8 1586 6.2e-175 Serine/threonine-protein phosphatase 4 catalytic subunit OS=Pongo abelii GN=PPP4C PE=2 SV=1 PF00149//PF01429 Calcineurin-like phosphoesterase//Methyl-CpG binding domain -- -- GO:0016787//GO:0003677 hydrolase activity//DNA binding GO:0005634 nucleus KOG0372 Serine/threonine specific protein phosphatase involved in glycogen accumulation, PP2A-related Cluster-8309.52537 BF_2 32.69 0.86 1875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05625 PAXNEB protein -- -- -- -- GO:0033588 Elongator holoenzyme complex -- -- Cluster-8309.52538 BF_2 37.87 1.31 1496 642935999 XP_973446.3 1343 1.8e-145 PREDICTED: uncharacterized protein YJR142W [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P47173 436 1.1e-41 Uncharacterized protein YJR142W OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YJR142W PE=1 SV=1 PF00293 NUDIX domain -- -- GO:0016787 hydrolase activity -- -- KOG4313 Thiamine pyrophosphokinase Cluster-8309.52539 BF_2 105.70 0.66 6958 642924922 XP_008194098.1 792 6.6e-81 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02205//PF01349 WH2 motif//Flavivirus non-structural protein NS4B GO:0006396//GO:0006370//GO:0009451//GO:0006144 RNA processing//7-methylguanosine mRNA capping//RNA modification//purine nucleobase metabolic process GO:0017111//GO:0004483//GO:0004252//GO:0016817//GO:0003968//GO:0070008//GO:0003779//GO:0004482 nucleoside-triphosphatase activity//mRNA (nucleoside-2'-O-)-methyltransferase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//RNA-directed RNA polymerase activity//serine-type exopeptidase activity//actin binding//mRNA (guanine-N7-)-methyltransferase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.5254 BF_2 9.24 0.49 1070 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52540 BF_2 119.48 0.84 6234 270006670 EFA03118.1 1114 2.7e-118 hypothetical protein TcasGA2_TC013028 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01349//PF02205 Flavivirus non-structural protein NS4B//WH2 motif GO:0006144//GO:0006396//GO:0009451//GO:0006370 purine nucleobase metabolic process//RNA processing//RNA modification//7-methylguanosine mRNA capping GO:0003779//GO:0004482//GO:0017111//GO:0004483//GO:0004252//GO:0016817//GO:0070008//GO:0003968 actin binding//mRNA (guanine-N7-)-methyltransferase activity//nucleoside-triphosphatase activity//mRNA (nucleoside-2'-O-)-methyltransferase activity//serine-type endopeptidase activity//hydrolase activity, acting on acid anhydrides//serine-type exopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.52543 BF_2 249.28 9.35 1403 270297198 NP_001161920.1 185 3.2e-11 peritrophic matrix protein 2-B precursor [Tribolium castaneum]>gi|268309034|gb|ACY95483.1| peritrophic matrix protein 2-B [Tribolium castaneum]>gi|270003976|gb|EFA00424.1| hypothetical protein TcasGA2_TC003275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.52547 BF_2 11.29 0.40 1462 478250714 ENN71206.1 387 1.3e-34 hypothetical protein YQE_12135, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52550 BF_2 245.49 1.82 5923 642937841 XP_008200323.1 1942 2.5e-214 PREDICTED: thyroid adenoma-associated protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8C756 578 1.5e-57 Thyroid adenoma-associated protein homolog OS=Mus musculus GN=Thada PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1810 Cell cycle-associated protein Cluster-8309.52551 BF_2 17.23 0.91 1079 640788486 XP_008050052.1 230 1.5e-16 PREDICTED: zinc finger protein 208-like, partial [Tarsius syrichta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 210 1.3e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13465//PF00096//PF07776//PF06221//PF13912//PF01363 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Putative zinc finger motif, C2HC5-type//C2H2-type zinc finger//FYVE zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.52557 BF_2 42.72 0.35 5444 642914333 XP_008201635.1 2633 1.7e-294 PREDICTED: glutamate receptor ionotropic, kainate 2 [Tribolium castaneum] 752869466 XM_011253546.1 368 0 PREDICTED: Camponotus floridanus glutamate receptor ionotropic, kainate 2 (LOC105248646), transcript variant X2, mRNA K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 Q13002 1448 1.8e-158 Glutamate receptor ionotropic, kainate 2 OS=Homo sapiens GN=GRIK2 PE=1 SV=1 PF10613//PF00060//PF15163 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel//Meiosis-expressed GO:0006811//GO:0007268//GO:0007165 ion transport//synaptic transmission//signal transduction GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.52561 BF_2 29.00 3.32 652 817061123 XP_012252151.1 161 9.1e-09 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02562 PhoH-like protein -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.52562 BF_2 119.37 1.52 3582 642918209 XP_008191412.1 1177 7.7e-126 PREDICTED: methyltransferase-like protein 9 isoform X1 [Tribolium castaneum]>gi|270004533|gb|EFA00981.1| hypothetical protein TcasGA2_TC003894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EPL4 639 7.7e-65 Methyltransferase-like protein 9 OS=Mus musculus GN=Mettl9 PE=2 SV=1 PF01234//PF04218//PF08241//PF05958 NNMT/PNMT/TEMT family//CENP-B N-terminal DNA-binding domain//Methyltransferase domain//tRNA (Uracil-5-)-methyltransferase GO:0009451//GO:0008152//GO:0006396 RNA modification//metabolic process//RNA processing GO:0003677//GO:0008168//GO:0008173 DNA binding//methyltransferase activity//RNA methyltransferase activity -- -- KOG3987 Uncharacterized conserved protein DREV/CGI-81 Cluster-8309.52567 BF_2 195.36 5.47 1782 642919019 XP_008191698.1 1526 1.3e-166 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1L8F9 535 4.4e-53 UPF0536 protein C12orf66 homolog OS=Danio rerio GN=si:ch211-125a15.1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5257 BF_2 1.00 0.99 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52571 BF_2 329.22 4.76 3180 642933791 XP_008197311.1 3775 0.0e+00 PREDICTED: multidrug resistance-associated protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 O35379 2210 4.6e-247 Multidrug resistance-associated protein 1 OS=Mus musculus GN=Abcc1 PE=1 SV=1 PF03193//PF17001//PF00005//PF01926//PF13304//PF00664 Protein of unknown function, DUF258//Type III secretion basal body protein I, YscI, HrpB, PscI//ABC transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810//GO:0009306 transmembrane transport//transport//protein secretion GO:0016887//GO:0005525//GO:0042626//GO:0005524//GO:0003924 ATPase activity//GTP binding//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.52576 BF_2 2.00 0.42 485 91076754 XP_973519.1 350 8.2e-31 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P94493 128 1.9e-06 Putative metabolite transport protein YncC OS=Bacillus subtilis (strain 168) GN=yncC PE=3 SV=2 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.52577 BF_2 55.95 0.43 5768 189241444 XP_972982.2 2726 3.0e-305 PREDICTED: uncharacterized protein LOC661743 isoform X1 [Tribolium castaneum] 642936623 XM_008200289.1 120 5.1493e-53 PREDICTED: Tribolium castaneum uncharacterized LOC661743 (LOC661743), transcript variant X3, mRNA -- -- -- -- O14513 244 7.8e-19 Nck-associated protein 5 OS=Homo sapiens GN=NCKAP5 PE=1 SV=2 PF01166//PF02346 TSC-22/dip/bun family//Chordopoxvirus multifunctional envelope protein A27 GO:0019064//GO:0006355 fusion of virus membrane with host plasma membrane//regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0019031 transcription factor complex//viral envelope -- -- Cluster-8309.52579 BF_2 22.00 1.21 1045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00906 Hepatitis core antigen GO:0009405 pathogenesis GO:0005198 structural molecule activity -- -- -- -- Cluster-8309.5258 BF_2 25.72 0.53 2323 546684844 ERL94426.1 363 1.2e-31 hypothetical protein D910_11704 [Dendroctonus ponderosae] -- -- -- -- -- K12321 GUCY2D_E_F guanylate cyclase 2D/E/F http://www.genome.jp/dbget-bin/www_bget?ko:K12321 Q9VEU5 266 8.9e-22 Soluble guanylate cyclase 89Db OS=Drosophila melanogaster GN=Gyc-89Db PE=1 SV=1 PF00211//PF02285 Adenylate and Guanylate cyclase catalytic domain//Cytochrome oxidase c subunit VIII GO:0006123//GO:0035556//GO:0015992//GO:0009190 mitochondrial electron transport, cytochrome c to oxygen//intracellular signal transduction//proton transport//cyclic nucleotide biosynthetic process GO:0016849//GO:0004129 phosphorus-oxygen lyase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.52580 BF_2 198.54 7.87 1342 828177651 AKK25148.1 438 1.4e-40 chemosensory protein 4 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 251 2.8e-20 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.52581 BF_2 193.34 2.02 4285 641649257 XP_008185321.1 466 2.6e-43 PREDICTED: uncharacterized protein LOC103310050 [Acyrthosiphon pisum] -- -- -- -- -- K12841 CHERP calcium homeostasis endoplasmic reticulum protein http://www.genome.jp/dbget-bin/www_bget?ko:K12841 Q8CGZ0 259 1.1e-20 Calcium homeostasis endoplasmic reticulum protein OS=Mus musculus GN=Cherp PE=1 SV=1 PF01585 G-patch domain -- -- GO:0003676 nucleic acid binding -- -- KOG4368 Predicted RNA binding protein, contains SWAP, RPR and G-patch domains Cluster-8309.52582 BF_2 226.00 4.19 2545 91079060 XP_975158.1 2827 0.0e+00 PREDICTED: polycomb protein Suz12 [Tribolium castaneum]>gi|270004197|gb|EFA00645.1| hypothetical protein TcasGA2_TC003521 [Tribolium castaneum] -- -- -- -- -- K11463 SUZ12 polycomb protein SUZ12 http://www.genome.jp/dbget-bin/www_bget?ko:K11463 Q80U70 1383 2.9e-151 Polycomb protein Suz12 OS=Mus musculus GN=Suz12 PE=1 SV=2 -- -- -- -- GO:0008270 zinc ion binding GO:0005622 intracellular KOG2350 Zn-finger protein joined to JAZF1 (predicted suppressor) Cluster-8309.52584 BF_2 322.40 11.33 1477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06682 SOCE-associated regulatory factor of calcium homoeostasis GO:2001256 regulation of store-operated calcium entry -- -- GO:0030176 integral component of endoplasmic reticulum membrane -- -- Cluster-8309.52585 BF_2 1000.75 2.89 14787 642914247 XP_008201606.1 18917 0.0e+00 PREDICTED: fat-like cadherin-related tumor suppressor homolog [Tribolium castaneum] 642914246 XM_008203384.1 1497 0 PREDICTED: Tribolium castaneum fat-like cadherin-related tumor suppressor homolog (LOC662569), mRNA K16506 FAT1_2_3 protocadherin Fat 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K16506 Q9VW71 10611 0.0e+00 Fat-like cadherin-related tumor suppressor homolog OS=Drosophila melanogaster GN=kug PE=2 SV=3 PF07645//PF00008//PF00028 Calcium-binding EGF domain//EGF-like domain//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016020 membrane KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.52586 BF_2 95.37 2.15 2145 91090216 XP_968004.1 1600 4.1e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.3e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008476//GO:0008146 protein-tyrosine sulfotransferase activity//sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.52589 BF_2 15.97 1.23 831 478250388 ENN70883.1 835 8.1e-87 hypothetical protein YQE_12288, partial [Dendroctonus ponderosae]>gi|546672880|gb|ERL84603.1| hypothetical protein D910_02031 [Dendroctonus ponderosae] 766925232 XM_011496200.1 50 5.86083e-15 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 481 3.7e-47 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 PF02196 Raf-like Ras-binding domain GO:0007165 signal transduction GO:0005057 receptor signaling protein activity -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.52592 BF_2 20.77 0.42 2379 91080555 XP_967130.1 440 1.5e-40 PREDICTED: clathrin light chain isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IY45 297 2.3e-25 Protein AMN1 homolog OS=Homo sapiens GN=AMN1 PE=2 SV=4 PF01086//PF13855 Clathrin light chain//Leucine rich repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0005198//GO:0005515 structural molecule activity//protein binding GO:0030130//GO:0030132 clathrin coat of trans-Golgi network vesicle//clathrin coat of coated pit -- -- Cluster-8309.52593 BF_2 26.60 0.35 3438 546682217 ERL92178.1 707 2.3e-71 hypothetical protein D910_09498 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q02942 259 8.5e-21 Transferrin OS=Blaberus discoidalis PE=1 SV=1 PF09445 RNA cap guanine-N2 methyltransferase GO:0009452//GO:0001510 7-methylguanosine RNA capping//RNA methylation GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.52595 BF_2 143.10 0.99 6350 390362249 XP_001190749.2 1176 1.8e-125 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q505D1 689 2.2e-70 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF01637//PF00023//PF08092//PF05396 Ankyrin repeat//Archaeal ATPase//Ankyrin repeat//Magi peptide toxin family//Phage T7 capsid assembly protein GO:0019069//GO:0006810 viral capsid assembly//transport GO:0005524//GO:0019871//GO:0005515 ATP binding//sodium channel inhibitor activity//protein binding GO:0005576 extracellular region KOG4177 Ankyrin Cluster-8309.52599 BF_2 30.08 0.46 3037 642934573 XP_008197722.1 1984 1.7e-219 PREDICTED: uncharacterized protein LOC658962 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10314 FBXO39 F-box protein 39 http://www.genome.jp/dbget-bin/www_bget?ko:K10314 -- -- -- -- PF00646//PF12937 F-box domain//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52601 BF_2 229.34 7.07 1644 91086285 XP_967226.1 1427 3.6e-155 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13129 1069 4.8e-115 Luciferin 4-monooxygenase OS=Luciola cruciata PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.52602 BF_2 79.12 1.83 2092 91086285 XP_967226.1 1505 4.1e-164 PREDICTED: luciferin 4-monooxygenase [Tribolium castaneum]>gi|270010269|gb|EFA06717.1| hypothetical protein TcasGA2_TC009648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13129 1101 1.2e-118 Luciferin 4-monooxygenase OS=Luciola cruciata PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.52605 BF_2 367.66 8.21 2160 546677792 ERL88559.1 1850 4.2e-204 hypothetical protein D910_05944 [Dendroctonus ponderosae] -- -- -- -- -- K13174 THOC5 THO complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13174 Q6NY52 904 8.6e-96 THO complex subunit 5 homolog OS=Danio rerio GN=thoc5 PE=2 SV=1 PF05773//PF05225 RWD domain//helix-turn-helix, Psq domain -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- KOG2216 Conserved coiled/coiled coil protein Cluster-8309.52606 BF_2 770.00 53.88 885 166919223 ABZ04009.1 572 2.7e-56 serine protease 1 [Costelytra zealandica] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P35037 496 7.2e-49 Trypsin-3 OS=Anopheles gambiae GN=TRYP3 PE=2 SV=5 PF00706//PF00089 Anenome neurotoxin//Trypsin GO:0009966//GO:0006508 regulation of signal transduction//proteolysis GO:0004252 serine-type endopeptidase activity GO:0005576 extracellular region -- -- Cluster-8309.52607 BF_2 4.83 0.53 667 332374634 AEE62458.1 293 4.6e-24 unknown [Dendroctonus ponderosae] -- -- -- -- -- K17607 TIPRL, TIP41 type 2A phosphatase activator TIP41 http://www.genome.jp/dbget-bin/www_bget?ko:K17607 O75663 179 3.1e-12 TIP41-like protein OS=Homo sapiens GN=TIPRL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52609 BF_2 75.00 1.15 3005 642937652 XP_966876.3 611 2.8e-60 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95LI3 435 2.9e-41 Zinc finger Y-chromosomal protein OS=Bos taurus GN=ZFY PE=2 SV=1 PF07776//PF05485//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//THAP domain//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0003676//GO:0008270 metal ion binding//nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.52610 BF_2 23.00 1.28 1040 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.52617 BF_2 34.00 0.79 2091 189233809 XP_971005.2 1228 5.5e-132 PREDICTED: protein trapped in endoderm-1 [Tribolium castaneum]>gi|270015127|gb|EFA11575.1| hypothetical protein TcasGA2_TC004716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NDM2 710 2.6e-73 Protein trapped in endoderm-1 OS=Drosophila melanogaster GN=Tre1 PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.52620 BF_2 420.55 4.85 3913 642928921 XP_008195617.1 5063 0.0e+00 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 1119 1.8e-120 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF03248 Rer1 family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.52622 BF_2 32.96 1.27 1377 642925645 XP_008194653.1 1380 8.5e-150 PREDICTED: potassium voltage-gated channel subfamily H member 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K04905 KCNH2 potassium voltage-gated channel Eag-related subfamily H member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04905 Q9TSZ3 297 1.3e-25 Potassium voltage-gated channel subfamily H member 2 OS=Canis familiaris GN=KCNH2 PE=2 SV=1 PF02213//PF00989//PF08447 GYF domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding -- -- -- -- Cluster-8309.52623 BF_2 632.42 4.19 6599 642916796 XP_008199507.1 3278 0.0e+00 PREDICTED: fibrillin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q61555 1031 5.0e-110 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF07645//PF00008 Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.52628 BF_2 19.21 1.25 929 746833442 XP_011063369.1 567 1.1e-55 PREDICTED: uncharacterized protein LOC105151387 [Acromyrmex echinatior] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52631 BF_2 17.66 0.91 1099 91083149 XP_971578.1 771 2.8e-79 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P05049 495 1.2e-48 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52633 BF_2 143.83 0.82 7649 642916594 XP_008191822.1 2395 9.6e-267 PREDICTED: alpha-catulin isoform X2 [Tribolium castaneum] 642916593 XM_008193600.1 723 0 PREDICTED: Tribolium castaneum alpha-catulin (LOC658111), transcript variant X2, mRNA -- -- -- -- Q9UBT7 960 9.8e-102 Alpha-catulin OS=Homo sapiens GN=CTNNAL1 PE=1 SV=2 PF08066//PF01044 PMC2NT (NUC016) domain//Vinculin family GO:0006396//GO:0007155 RNA processing//cell adhesion GO:0051015 actin filament binding GO:0000176 nuclear exosome (RNase complex) KOG3681 Alpha-catenin Cluster-8309.52635 BF_2 311.77 2.58 5349 642929988 XP_008196055.1 2169 1.1e-240 PREDICTED: patj homolog [Tribolium castaneum] -- -- -- -- -- K13804 INAD inactivation no afterpotential D protein http://www.genome.jp/dbget-bin/www_bget?ko:K13804 Q9NB04 727 7.2e-75 Patj homolog OS=Drosophila melanogaster GN=Patj PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG3528 FOG: PDZ domain Cluster-8309.52638 BF_2 136.05 2.44 2617 642921104 XP_008192691.1 1190 1.7e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.7e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678//PF09726//PF05279//PF04882//PF02535 Centriole duplication and mitotic chromosome congression//Transmembrane protein//Aspartyl beta-hydroxylase N-terminal region//Peroxin-3//ZIP Zinc transporter GO:0007031//GO:0055085//GO:0030001//GO:0090307 peroxisome organization//transmembrane transport//metal ion transport//mitotic spindle assembly GO:0046873 metal ion transmembrane transporter activity GO:0016021//GO:0016020//GO:0005779 integral component of membrane//membrane//integral component of peroxisomal membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.52642 BF_2 11.00 0.65 995 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52644 BF_2 662.95 26.04 1352 91088179 XP_972438.1 1205 1.6e-129 PREDICTED: hydroxyacylglutathione hydrolase, mitochondrial [Tribolium castaneum]>gi|270012133|gb|EFA08581.1| hypothetical protein TcasGA2_TC006236 [Tribolium castaneum] -- -- -- -- -- K01069 E3.1.2.6, gloB hydroxyacylglutathione hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01069 Q6P963 899 2.1e-95 Hydroxyacylglutathione hydrolase, mitochondrial OS=Danio rerio GN=hagh PE=2 SV=2 -- -- GO:0006750//GO:0006090 glutathione biosynthetic process//pyruvate metabolic process GO:0004416//GO:0008270 hydroxyacylglutathione hydrolase activity//zinc ion binding -- -- KOG0813 Glyoxylase Cluster-8309.52645 BF_2 24.18 1.05 1247 91090398 XP_970402.1 723 1.2e-73 PREDICTED: mediator of RNA polymerase II transcription subunit 19 [Tribolium castaneum]>gi|270013384|gb|EFA09832.1| hypothetical protein TcasGA2_TC011979 [Tribolium castaneum] 665785746 XM_008550626.1 157 2.94371e-74 PREDICTED: Microplitis demolitor mediator of RNA polymerase II transcription subunit 19 (LOC103572159), mRNA K15137 MED19 mediator of RNA polymerase II transcription subunit 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15137 Q174D3 648 2.4e-66 Mediator of RNA polymerase II transcription subunit 19 OS=Aedes aegypti GN=MED19 PE=3 SV=1 PF10278 Mediator of RNA pol II transcription subunit 19 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.52648 BF_2 133.53 3.13 2074 642911136 XP_008200596.1 1380 1.3e-149 PREDICTED: mitochondrial folate transporter/carrier isoform X1 [Tribolium castaneum]>gi|270014598|gb|EFA11046.1| hypothetical protein TcasGA2_TC004639, partial [Tribolium castaneum] -- -- -- -- -- K15115 SLC25A32, MFT solute carrier family 25 (mitochondrial folate transporter), member 32 http://www.genome.jp/dbget-bin/www_bget?ko:K15115 Q8BMG8 810 6.6e-85 Mitochondrial folate transporter/carrier OS=Mus musculus GN=Slc25a32 PE=2 SV=1 -- -- GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG0764 Mitochondrial FAD carrier protein Cluster-8309.52649 BF_2 17.00 0.74 1253 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52652 BF_2 38.12 0.39 4402 91085935 XP_970328.1 5241 0.0e+00 PREDICTED: 5-oxoprolinase [Tribolium castaneum] 642927487 XM_965235.3 600 0 PREDICTED: Tribolium castaneum 5-oxoprolinase (LOC658884), mRNA K01469 OPLAH, OXP1, oplAH 5-oxoprolinase (ATP-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01469 P97608 4092 0.0e+00 5-oxoprolinase OS=Rattus norvegicus GN=Oplah PE=1 SV=2 PF02538//PF01968 Hydantoinase B/oxoprolinase//Hydantoinase/oxoprolinase -- -- GO:0003824//GO:0016787 catalytic activity//hydrolase activity -- -- KOG1939 Oxoprolinase Cluster-8309.52654 BF_2 67.00 4.03 982 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52655 BF_2 669.13 6.80 4401 91085935 XP_970328.1 5241 0.0e+00 PREDICTED: 5-oxoprolinase [Tribolium castaneum] 642927487 XM_965235.3 600 0 PREDICTED: Tribolium castaneum 5-oxoprolinase (LOC658884), mRNA K01469 OPLAH, OXP1, oplAH 5-oxoprolinase (ATP-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01469 P97608 4092 0.0e+00 5-oxoprolinase OS=Rattus norvegicus GN=Oplah PE=1 SV=2 PF02538//PF01968 Hydantoinase B/oxoprolinase//Hydantoinase/oxoprolinase -- -- GO:0016787//GO:0003824 hydrolase activity//catalytic activity -- -- KOG1939 Oxoprolinase Cluster-8309.52657 BF_2 17.23 0.70 1310 546684929 ERL94511.1 236 3.7e-17 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.52658 BF_2 44.48 0.91 2321 546684266 ERL93971.1 624 6.6e-62 hypothetical protein D910_11256 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52659 BF_2 156.82 2.79 2636 546684266 ERL93971.1 609 4.1e-60 hypothetical protein D910_11256 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52663 BF_2 4.00 0.39 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52664 BF_2 231.94 7.26 1624 332375126 AEE62704.1 758 1.3e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q63528 327 5.2e-29 Replication protein A 32 kDa subunit OS=Rattus norvegicus GN=Rpa2 PE=2 SV=2 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG3108 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit Cluster-8309.52667 BF_2 12.00 2.12 524 388593712 AFK73916.1 296 1.6e-24 mast/stem cell growth factor receptor isoform-2 [Ovis aries] 170014706 NG_007456.1 524 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 Q08156 260 9.9e-22 Mast/stem cell growth factor receptor Kit OS=Gallus gallus GN=KIT PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.52668 BF_2 154.92 4.49 1729 91087015 XP_974102.1 890 7.1e-93 PREDICTED: protein phosphatase 1 regulatory subunit 21 [Tribolium castaneum]>gi|270009633|gb|EFA06081.1| hypothetical protein TcasGA2_TC008917 [Tribolium castaneum] -- -- -- -- -- K17562 PPP1R21, CCDC128, KLRAQ1 protein phosphatase 1 regulatory subunit 21 http://www.genome.jp/dbget-bin/www_bget?ko:K17562 Q5U3A8 272 1.3e-22 Protein phosphatase 1 regulatory subunit 21 OS=Danio rerio GN=ppp1r21 PE=2 SV=1 PF12639 DNase/tRNase domain of colicin-like bacteriocin -- -- GO:0004519 endonuclease activity -- -- KOG4421 Uncharacterized conserved protein Cluster-8309.52669 BF_2 19.00 0.45 2045 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52670 BF_2 153.39 6.35 1298 749784476 XP_011146090.1 572 4.0e-56 PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784479|ref|XP_011146091.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784482|ref|XP_011146092.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784485|ref|XP_011146093.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator]>gi|749784488|ref|XP_011146094.1| PREDICTED: motile sperm domain-containing protein 1-like [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- Q9UJG1 401 1.1e-37 Motile sperm domain-containing protein 1 OS=Homo sapiens GN=MOSPD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52674 BF_2 280.39 4.82 2721 546682401 ERL92343.1 1196 3.7e-128 hypothetical protein D910_09660 [Dendroctonus ponderosae] -- -- -- -- -- K14648 ENDOU, PP11 poly(U)-specific endoribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K14648 Q9VZ49 735 4.3e-76 Poly(U)-specific endoribonuclease homolog OS=Drosophila melanogaster GN=CG2145 PE=1 SV=1 PF09412 Endoribonuclease XendoU -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2849 Placental protein 11 Cluster-8309.52676 BF_2 183.59 2.84 2990 642926793 XP_008195018.1 3206 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: ankyrin repeat and FYVE domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q810B6 1857 3.7e-206 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF01068//PF00651//PF00023//PF13606 ATP dependent DNA ligase domain//BTB/POZ domain//Ankyrin repeat//Ankyrin repeat GO:0006281//GO:0006260//GO:0006310 DNA repair//DNA replication//DNA recombination GO:0003910//GO:0005515//GO:0005524 DNA ligase (ATP) activity//protein binding//ATP binding -- -- KOG4177 Ankyrin Cluster-8309.52678 BF_2 90.00 1.50 2802 478255092 ENN75322.1 478 6.8e-45 hypothetical protein YQE_08099, partial [Dendroctonus ponderosae]>gi|546678671|gb|ERL89239.1| hypothetical protein D910_06613 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52680 BF_2 33.62 0.32 4698 270002048 EEZ98495.1 367 8.5e-32 hypothetical protein TcasGA2_TC000995 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.52681 BF_2 8.06 0.97 634 270006907 EFA03355.1 315 1.2e-26 hypothetical protein TcasGA2_TC013340 [Tribolium castaneum] -- -- -- -- -- K00643 E2.3.1.37, ALAS 5-aminolevulinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00643 Q5R9R9 278 9.8e-24 5-aminolevulinate synthase, nonspecific, mitochondrial OS=Pongo abelii GN=ALAS1 PE=2 SV=1 PF00570//PF00155//PF01053 HRDC domain//Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0003676//GO:0030170 nucleic acid binding//pyridoxal phosphate binding GO:0005622 intracellular KOG1360 5-aminolevulinate synthase Cluster-8309.52683 BF_2 32.72 0.36 4093 91094947 XP_968721.1 1275 3.8e-137 PREDICTED: protein DENND6A [Tribolium castaneum]>gi|270015088|gb|EFA11536.1| hypothetical protein TcasGA2_TC016056 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BH65 866 4.2e-91 Protein DENND6A OS=Mus musculus GN=Dennd6a PE=2 SV=1 PF10018//PF06815 Vitamin-D-receptor interacting Mediator subunit 4//Reverse transcriptase connection domain GO:0006357//GO:0006278 regulation of transcription from RNA polymerase II promoter//RNA-dependent DNA replication GO:0003964//GO:0001104 RNA-directed DNA polymerase activity//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG2432 Uncharacterized conserved protein Cluster-8309.52684 BF_2 63.65 0.43 6433 478251276 ENN71747.1 2069 5.1e-229 hypothetical protein YQE_11567, partial [Dendroctonus ponderosae] -- -- -- -- -- K18164 NDUFAF7 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18164 Q5XI79 955 3.1e-101 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 OS=Rattus norvegicus GN=Ndufaf7 PE=2 SV=1 PF10192//PF06814 Rhodopsin-like GPCR transmembrane domain//Lung seven transmembrane receptor GO:0007186//GO:0019236 G-protein coupled receptor signaling pathway//response to pheromone -- -- GO:0016021 integral component of membrane KOG2901 Uncharacterized conserved protein Cluster-8309.52687 BF_2 127.78 0.80 6989 91087949 XP_972541.1 1210 2.2e-129 PREDICTED: rhomboid-related protein 2 [Tribolium castaneum]>gi|270012034|gb|EFA08482.1| hypothetical protein TcasGA2_TC006133 [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P58872 416 1.1e-38 Rhomboid-related protein 3 OS=Homo sapiens GN=RHBDL3 PE=2 SV=1 PF12763//PF13606//PF13499//PF13833//PF10591//PF13405//PF13202//PF01694//PF00023//PF00036 Cytoskeletal-regulatory complex EF hand//Ankyrin repeat//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//Rhomboid family//Ankyrin repeat//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515//GO:0004252 calcium ion binding//protein binding//serine-type endopeptidase activity GO:0005578//GO:0016021 proteinaceous extracellular matrix//integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.52691 BF_2 123.09 1.15 4751 546678797 ERL89342.1 3014 0.0e+00 hypothetical protein D910_06713 [Dendroctonus ponderosae] 356871507 FO082054.1 40 1.2551e-08 Pichia sorbitophila strain CBS 7064 chromosome F complete sequence K01950 E6.3.5.1, NADSYN1, QNS1, nadE NAD+ synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01950 Q9VYA0 2602 2.4e-292 Probable glutamine-dependent NAD(+) synthetase OS=Drosophila melanogaster GN=CG9940 PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG2303 Predicted NAD synthase, contains CN hydrolase domain Cluster-8309.52692 BF_2 165.32 1.64 4507 91080973 XP_974893.1 1926 1.4e-212 PREDICTED: probable glutamine-dependent NAD(+) synthetase [Tribolium castaneum]>gi|642919960|ref|XP_008192145.1| PREDICTED: probable glutamine-dependent NAD(+) synthetase [Tribolium castaneum]>gi|270005354|gb|EFA01802.1| hypothetical protein TcasGA2_TC007403 [Tribolium castaneum] 356871507 FO082054.1 40 1.19015e-08 Pichia sorbitophila strain CBS 7064 chromosome F complete sequence K01950 E6.3.5.1, NADSYN1, QNS1, nadE NAD+ synthase (glutamine-hydrolysing) http://www.genome.jp/dbget-bin/www_bget?ko:K01950 Q9VYA0 1589 6.7e-175 Probable glutamine-dependent NAD(+) synthetase OS=Drosophila melanogaster GN=CG9940 PE=1 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807//GO:0046497//GO:0009435 nitrogen compound metabolic process//nicotinate nucleotide metabolic process//NAD biosynthetic process GO:0016810//GO:0005524//GO:0003952 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds//ATP binding//NAD+ synthase (glutamine-hydrolyzing) activity -- -- KOG2303 Predicted NAD synthase, contains CN hydrolase domain Cluster-8309.52697 BF_2 80.45 0.99 3675 91092536 XP_967769.1 2382 1.5e-265 PREDICTED: serine/threonine-protein kinase PAK 3 [Tribolium castaneum]>gi|270006610|gb|EFA03058.1| hypothetical protein TcasGA2_TC010914 [Tribolium castaneum] 642921728 XM_962676.2 515 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase PAK 3 (LOC656127), mRNA K05733 PAK3, MRX30 p21-activated kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05733 Q62829 1611 1.5e-177 Serine/threonine-protein kinase PAK 3 OS=Rattus norvegicus GN=Pak3 PE=1 SV=1 PF07714//PF06293//PF00069//PF05861 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Bacterial phosphonate metabolism protein (PhnI) GO:0019634//GO:0016310//GO:0009069//GO:0006468 organic phosphonate metabolic process//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004674//GO:0004672//GO:0016773//GO:0005524 protein serine/threonine kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0578 p21-activated serine/threonine protein kinase Cluster-8309.52698 BF_2 282.27 3.58 3581 642917305 XP_008199244.1 5318 0.0e+00 PREDICTED: disco-interacting protein 2 isoform X5 [Tribolium castaneum] 642917304 XM_008201022.1 925 0 PREDICTED: Tribolium castaneum disco-interacting protein 2 (LOC657292), transcript variant X5, mRNA -- -- -- -- Q9W0S9 3637 0.0e+00 Disco-interacting protein 2 OS=Drosophila melanogaster GN=DIP2 PE=1 SV=2 PF00501//PF17096//PF06464 AMP-binding enzyme//Altered inheritance of mitochondria protein 3//DMAP1-binding Domain GO:0008152//GO:0051016 metabolic process//barbed-end actin filament capping GO:0003824//GO:0008134 catalytic activity//transcription factor binding GO:0005634//GO:0030479//GO:0005667 nucleus//actin cortical patch//transcription factor complex KOG3628 Predicted AMP-binding protein Cluster-8309.52699 BF_2 26.00 1.68 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03444 Winged helix-turn-helix transcription repressor, HrcA DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.52701 BF_2 123.00 3.78 1647 665794862 XP_008545150.1 679 2.0e-68 PREDICTED: nuclear transcription factor Y subunit gamma-like isoform X2 [Microplitis demolitor] -- -- -- -- -- K08066 NFYC nuclear transcription factor Y, gamma http://www.genome.jp/dbget-bin/www_bget?ko:K08066 Q5RA23 501 3.5e-49 Nuclear transcription factor Y subunit gamma OS=Pongo abelii GN=NFYC PE=2 SV=1 PF02969//PF09415//PF00125 TATA box binding protein associated factor (TAF)//CENP-S associating Centromere protein X//Core histone H2A/H2B/H3/H4 GO:0051382//GO:0006352//GO:0006281 kinetochore assembly//DNA-templated transcription, initiation//DNA repair GO:0003677 DNA binding GO:0005634 nucleus KOG1657 CCAAT-binding factor, subunit C (HAP5) Cluster-8309.52702 BF_2 78.00 0.99 3570 642937652 XP_966876.3 248 4.1e-18 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P52746 170 1.8e-10 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF07776//PF00096//PF13465//PF02150 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain//RNA polymerases M/15 Kd subunit GO:0006206//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0008270//GO:0003899//GO:0003677 metal ion binding//zinc ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005634 nucleolus//nucleus -- -- Cluster-8309.52703 BF_2 22.48 0.88 1360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52704 BF_2 27.57 0.49 2656 642937442 XP_008198836.1 676 7.1e-68 PREDICTED: uncharacterized protein LOC103314470 [Tribolium castaneum] -- -- -- -- -- K02088 CDK3 cyclin-dependent kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02088 P43450 262 3.0e-21 Cyclin-dependent kinase 2 OS=Carassius auratus GN=cdk2 PE=2 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.52705 BF_2 137.43 2.02 3138 478256147 ENN76345.1 1286 1.5e-138 hypothetical protein YQE_07122, partial [Dendroctonus ponderosae]>gi|546685758|gb|ERL95213.1| hypothetical protein D910_12480 [Dendroctonus ponderosae] -- -- -- -- -- K02088 CDK3 cyclin-dependent kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K02088 P43450 909 3.3e-96 Cyclin-dependent kinase 2 OS=Carassius auratus GN=cdk2 PE=2 SV=1 PF06293//PF00069//PF02098//PF07714//PF04062 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Tick histamine binding protein//Protein tyrosine kinase//ARP2/3 complex ARPC3 (21 kDa) subunit GO:0030833//GO:0006468//GO:0030682//GO:0034314 regulation of actin filament polymerization//protein phosphorylation//evasion or tolerance of host defense response//Arp2/3 complex-mediated actin nucleation GO:0005524//GO:0043176//GO:0016773//GO:0004672 ATP binding//amine binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0005856//GO:0005885//GO:0016020 cytoskeleton//Arp2/3 protein complex//membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.52706 BF_2 53.09 0.37 6296 546685591 ERL95078.1 318 5.5e-26 hypothetical protein D910_12348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5UPA0 134 4.9e-06 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 PF01668 SmpB protein -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.52717 BF_2 311.24 5.25 2767 91095029 XP_966439.1 854 1.7e-88 PREDICTED: ubiquitin-conjugating enzyme E2 H [Tribolium castaneum]>gi|270014763|gb|EFA11211.1| hypothetical protein TcasGA2_TC005175 [Tribolium castaneum] 462332992 APGK01039128.1 55 3.33476e-17 Dendroctonus ponderosae Seq01039138, whole genome shotgun sequence K10576 UBE2H, UBC8 ubiquitin-conjugating enzyme E2 H http://www.genome.jp/dbget-bin/www_bget?ko:K10576 P62257 751 6.1e-78 Ubiquitin-conjugating enzyme E2 H OS=Mus musculus GN=Ube2h PE=1 SV=1 PF05773 RWD domain -- -- GO:0005524//GO:0016881//GO:0005515 ATP binding//acid-amino acid ligase activity//protein binding -- -- KOG0416 Ubiquitin-protein ligase Cluster-8309.5272 BF_2 16.22 0.44 1832 546681838 ERL91853.1 231 1.9e-16 hypothetical protein D910_09178 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N695 138 4.9e-07 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF05529 B-cell receptor-associated protein 31-like GO:0006886 intracellular protein transport -- -- GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane -- -- Cluster-8309.52720 BF_2 60.00 1.14 2496 642929103 XP_008195691.1 417 7.2e-38 PREDICTED: uncharacterized protein LOC655454 [Tribolium castaneum]>gi|270010386|gb|EFA06834.1| hypothetical protein TcasGA2_TC009777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52721 BF_2 65.42 0.41 6951 270005904 EFA02352.1 2947 0.0e+00 hypothetical protein TcasGA2_TC008022 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70472 754 6.9e-78 Transmembrane protein 131 OS=Mus musculus GN=Tmem131 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3321 Mitochondrial ribosomal protein S10 Cluster-8309.52726 BF_2 49.60 2.39 1154 332372714 AEE61499.1 236 3.2e-17 unknown [Dendroctonus ponderosae]>gi|478259035|gb|ENN78981.1| hypothetical protein YQE_04565, partial [Dendroctonus ponderosae]>gi|546684157|gb|ERL93862.1| hypothetical protein D910_11148 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06459 Ryanodine Receptor TM 4-6 GO:0006874//GO:0006816 cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0016021//GO:0005622 integral component of membrane//intracellular -- -- Cluster-8309.52730 BF_2 364.78 0.87 17748 642935122 XP_008197897.1 21876 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1002 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q61555 1378 7.7e-150 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF06553//PF00008//PF07645 BNIP3//EGF-like domain//Calcium-binding EGF domain GO:0043065 positive regulation of apoptotic process GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005740//GO:0016021 mitochondrial envelope//integral component of membrane -- -- Cluster-8309.52732 BF_2 77.00 1.57 2340 642914629 XP_008190291.1 622 1.1e-61 PREDICTED: uncharacterized protein LOC103312160 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52733 BF_2 15.38 0.42 1809 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52735 BF_2 2.00 0.43 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52736 BF_2 8.00 1.80 473 817342125 XP_012296588.1 267 3.4e-21 PREDICTED: mast/stem cell growth factor receptor Kit isoform X1 [Aotus nancymaae] 170014706 NG_007456.1 473 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P10721 267 1.4e-22 Mast/stem cell growth factor receptor Kit OS=Homo sapiens GN=KIT PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52741 BF_2 9.94 0.31 1608 270016720 EFA13166.1 202 3.9e-13 hypothetical protein TcasGA2_TC002235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7KQZ4 159 1.6e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF13465//PF00096//PF05485 Zinc-finger double domain//Zinc finger, C2H2 type//THAP domain -- -- GO:0046872//GO:0003676 metal ion binding//nucleic acid binding -- -- -- -- Cluster-8309.52748 BF_2 3.00 0.35 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52753 BF_2 326.53 2.85 5077 642913582 XP_008201072.1 4497 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 21 [Tribolium castaneum] -- -- -- -- -- K18025 PTPN14_21 tyrosine-protein phosphatase non-receptor type 14/21 http://www.genome.jp/dbget-bin/www_bget?ko:K18025 Q15678 648 9.8e-66 Tyrosine-protein phosphatase non-receptor type 14 OS=Homo sapiens GN=PTPN14 PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.52755 BF_2 591.00 26.39 1224 91075982 XP_969958.1 686 2.3e-69 PREDICTED: inactive pancreatic lipase-related protein 1 [Tribolium castaneum]>gi|270014614|gb|EFA11062.1| hypothetical protein TcasGA2_TC004657 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17RR3 357 1.3e-32 Pancreatic lipase-related protein 3 OS=Homo sapiens GN=PNLIPRP3 PE=2 SV=2 PF01764//PF07819 Lipase (class 3)//PGAP1-like protein GO:0006505//GO:0006629//GO:0006886 GPI anchor metabolic process//lipid metabolic process//intracellular protein transport GO:0003824//GO:0016788 catalytic activity//hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.52761 BF_2 70.19 0.39 7747 170286893 BAG13448.1 5824 0.0e+00 chitinase [Monochamus alternatus] 170286892 AB428669.1 3470 0 Monochamus alternatus MaChiPm1 mRNA for chitinase, complete cds K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W5U2 1858 7.4e-206 Probable chitinase 3 OS=Drosophila melanogaster GN=Cht3 PE=2 SV=2 PF01607//PF00704//PF03970 Chitin binding Peritrophin-A domain//Glycosyl hydrolases family 18//Herpesvirus UL37 tegument protein GO:0006030//GO:0005975//GO:0019068 chitin metabolic process//carbohydrate metabolic process//virion assembly GO:0004553//GO:0008061 hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.52768 BF_2 112.00 2.84 1936 642924077 XP_008193997.1 962 3.5e-101 PREDICTED: rho-associated protein kinase 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04632 Fusaric acid resistance protein family GO:0006810 transport -- -- GO:0005886 plasma membrane -- -- Cluster-8309.52769 BF_2 144.00 2.30 2907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0055114//GO:0035556 oxidation-reduction process//intracellular signal transduction GO:0047134 protein-disulfide reductase activity -- -- -- -- Cluster-8309.52770 BF_2 119.98 1.47 3690 478250074 ENN70580.1 978 9.4e-103 hypothetical protein YQE_12755, partial [Dendroctonus ponderosae]>gi|546672658|gb|ERL84454.1| hypothetical protein D910_01886 [Dendroctonus ponderosae] 642933290 XM_008199137.1 98 5.57113e-41 PREDICTED: Tribolium castaneum cytochrome b5 reductase 4 (LOC656620), transcript variant X2, mRNA K00326 E1.6.2.2 cytochrome-b5 reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00326 Q68EJ0 395 1.6e-36 Cytochrome b5 reductase 4 OS=Rattus norvegicus GN=Cyb5r4 PE=1 SV=2 PF00175//PF08030 Oxidoreductase NAD-binding domain//Ferric reductase NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0536 Flavohemoprotein b5+b5R Cluster-8309.52775 BF_2 7.79 0.44 1025 578359018 AHI15752.1 1217 5.1e-131 glycoside hydrolase family 45 [Apriona japonica] 578359017 KJ186854.1 821 0 Apriona japonica glycoside hydrolase family 45 (gh45-1) mRNA, complete cds -- -- -- -- O97401 743 1.9e-77 Endoglucanase OS=Phaedon cochleariae PE=2 SV=1 PF02015 Glycosyl hydrolase family 45 GO:0005975//GO:0005982//GO:0005985 carbohydrate metabolic process//starch metabolic process//sucrose metabolic process GO:0008810 cellulase activity -- -- -- -- Cluster-8309.52777 BF_2 218.63 3.83 2675 189241705 XP_967022.2 1546 9.4e-169 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q9FN05 1166 4.5e-126 Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.52778 BF_2 4.00 0.66 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52783 BF_2 29.40 0.66 2138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52784 BF_2 1.00 4.10 259 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52786 BF_2 43.60 4.35 706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.52794 BF_2 39.25 0.78 2400 478256664 ENN76846.1 1026 1.7e-108 hypothetical protein YQE_06687, partial [Dendroctonus ponderosae]>gi|546685138|gb|ERL94665.1| hypothetical protein D910_11940 [Dendroctonus ponderosae] 815782412 XM_012359088.1 110 7.69802e-48 PREDICTED: Linepithema humile adenylate kinase (LOC105667343), mRNA K00939 adk, AK adenylate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00939 Q9U915 954 1.5e-101 Adenylate kinase OS=Drosophila melanogaster GN=Adk2 PE=1 SV=1 PF02224//PF02892//PF05191 Cytidylate kinase//BED zinc finger//Adenylate kinase, active site lid GO:0006139//GO:0046034//GO:0006144//GO:0006206 nucleobase-containing compound metabolic process//ATP metabolic process//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0005524//GO:0004127//GO:0004017 DNA binding//ATP binding//cytidylate kinase activity//adenylate kinase activity -- -- KOG3078 Adenylate kinase Cluster-8309.52796 BF_2 12.94 0.51 1342 91090910 XP_973922.1 973 1.3e-102 PREDICTED: protein rogdi isoform X1 [Tribolium castaneum]>gi|270013221|gb|EFA09669.1| hypothetical protein TcasGA2_TC011795 [Tribolium castaneum] 805780431 XM_012283623.1 73 1.57402e-27 PREDICTED: Megachile rotundata protein rogdi (LOC100879337), transcript variant X2, mRNA -- -- -- -- Q9VVE2 728 1.4e-75 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 PF11047 Salmonella outer protein D GO:0009405 pathogenesis -- -- GO:0033644 host cell membrane KOG3992 Uncharacterized conserved protein Cluster-8309.52797 BF_2 40.77 0.98 2025 270008035 EFA04483.1 1789 4.7e-197 hypothetical protein TcasGA2_TC014788 [Tribolium castaneum] -- -- -- -- -- K13710 ARHGEF7, PIXB Rho guanine nucleotide exchange factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K13710 Q9ES28 912 9.6e-97 Rho guanine nucleotide exchange factor 7 OS=Mus musculus GN=Arhgef7 PE=1 SV=2 PF00621//PF14604//PF00018 RhoGEF domain//Variant SH3 domain//SH3 domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG2070 Guanine nucleotide exchange factor Cluster-8309.52800 BF_2 7.00 0.45 944 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52801 BF_2 73.49 2.30 1624 478259957 ENN79759.1 1218 6.1e-131 hypothetical protein YQE_03815, partial [Dendroctonus ponderosae]>gi|546681505|gb|ERL91582.1| hypothetical protein D910_08912 [Dendroctonus ponderosae] -- -- -- -- -- K05614 SLC1A3, EAAT1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05614 P46411 781 1.2e-81 Excitatory amino acid transporter 1 OS=Bos taurus GN=SLC1A3 PE=2 SV=1 PF00375 Sodium:dicarboxylate symporter family GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.52802 BF_2 67.67 1.36 2369 646707673 KDR14328.1 1008 2.0e-106 hypothetical protein L798_11418, partial [Zootermopsis nevadensis] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 P43006 862 7.0e-91 Excitatory amino acid transporter 2 OS=Mus musculus GN=Slc1a2 PE=1 SV=1 PF00375//PF07810 Sodium:dicarboxylate symporter family//TMC domain GO:0006820//GO:0006835//GO:0006812 anion transport//dicarboxylic acid transport//cation transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.52803 BF_2 73.95 1.93 1894 728418191 AIY68360.1 337 1.0e-28 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08563//PF06422 P53 transactivation motif//CDR ABC transporter GO:0006810 transport GO:0005524//GO:0005515//GO:0042626 ATP binding//protein binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.52807 BF_2 124.02 1.49 3775 642911809 XP_008200752.1 3666 0.0e+00 PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911811|ref|XP_008200753.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum]>gi|642911813|ref|XP_008200754.1| PREDICTED: protein SZT2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A9C3 1444 3.7e-158 Protein SZT2 OS=Mus musculus GN=Szt2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52810 BF_2 1.00 0.42 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52811 BF_2 266.21 5.25 2408 91088039 XP_974446.1 1345 1.7e-145 PREDICTED: erlin-1 [Tribolium castaneum]>gi|270012079|gb|EFA08527.1| hypothetical protein TcasGA2_TC006180 [Tribolium castaneum] 827559147 XM_012695171.1 184 5.64251e-89 PREDICTED: Bombyx mori erlin-2-like (LOC101740340), transcript variant X3, mRNA -- -- -- -- Q28J34 987 2.3e-105 Erlin-2 OS=Xenopus tropicalis GN=erlin2 PE=2 SV=1 PF00318 Ribosomal protein S2 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2962 Prohibitin-related membrane protease subunits Cluster-8309.52815 BF_2 1776.22 133.44 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52817 BF_2 2.14 0.34 552 646708837 KDR14984.1 203 1.0e-13 Sodium-coupled monocarboxylate transporter 1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8BYF6 135 3.3e-07 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.52820 BF_2 4.00 0.48 638 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52821 BF_2 205.30 2.15 4283 642937652 XP_966876.3 827 3.5e-85 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6B4Z5 368 2.4e-33 Zinc finger Y-chromosomal protein OS=Pan troglodytes GN=ZFY PE=2 SV=1 PF02738//PF13465//PF00096 Molybdopterin-binding domain of aldehyde dehydrogenase//Zinc-finger double domain//Zinc finger, C2H2 type GO:0055114 oxidation-reduction process GO:0016491//GO:0046872 oxidoreductase activity//metal ion binding -- -- -- -- Cluster-8309.52822 BF_2 24.10 0.34 3286 478250207 ENN70710.1 2602 4.1e-291 hypothetical protein YQE_12655, partial [Dendroctonus ponderosae] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1318 1.3e-143 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00233 3'5'-cyclic nucleotide phosphodiesterase GO:0006144//GO:0007165 purine nucleobase metabolic process//signal transduction GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity -- -- KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.52823 BF_2 71.00 2.00 1773 167234449 NP_001107839.1 919 3.1e-96 eagle [Tribolium castaneum]>gi|270004095|gb|EFA00543.1| hypothetical protein TcasGA2_TC003409 [Tribolium castaneum] 41223450 AJ621748.1 205 8.75767e-101 Tribolium castaneum partial mRNA for zinc finger transcription factor (eagle gene) K08706 NR0AN, kni nuclear receptor subfamily 0 group A http://www.genome.jp/dbget-bin/www_bget?ko:K08706 P13054 490 7.2e-48 Knirps-related protein OS=Drosophila melanogaster GN=knrl PE=2 SV=1 PF00105 Zinc finger, C4 type (two domains) GO:0006355//GO:0009987 regulation of transcription, DNA-templated//cellular process GO:0043565//GO:0005488//GO:0008270//GO:0003700 sequence-specific DNA binding//binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4216 Steroid hormone nuclear receptor Cluster-8309.52826 BF_2 14.00 0.47 1537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02145 Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.52828 BF_2 264.12 3.09 3860 642915691 XP_008190761.1 3109 0.0e+00 PREDICTED: cyclic nucleotide-gated cation channel subunit A [Tribolium castaneum] 170060746 XM_001865903.1 397 0 Culex quinquefasciatus cyclic-nucleotide-gated cation channel, mRNA K04950 CNGA3 cyclic nucleotide gated channel alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04950 Q24278 2169 3.2e-242 Cyclic nucleotide-gated cation channel subunit A OS=Drosophila melanogaster GN=CngA PE=2 SV=2 PF05929//PF00520//PF02173 Phage capsid scaffolding protein (GPO) serine peptidase//Ion transport protein//pKID domain GO:0006355//GO:0055085//GO:0019069//GO:0006811 regulation of transcription, DNA-templated//transmembrane transport//viral capsid assembly//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.52830 BF_2 559.97 3.99 6156 742090774 XP_010831732.1 714 6.4e-72 PREDICTED: zinc finger protein 665-like, partial [Bison bison bison] 297723644 NM_001187257.1 43 3.50153e-10 Oryza sativa Japonica Group Os05g0117798 (Os05g0117798) mRNA, complete cds K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q14590 669 4.4e-68 Zinc finger protein 235 OS=Homo sapiens GN=ZNF235 PE=2 SV=3 PF07975//PF13465//PF00225//PF16622//PF13912//PF00096//PF07776//PF06467//PF05531 TFIIH C1-like domain//Zinc-finger double domain//Kinesin motor domain//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//Nucleopolyhedrovirus P10 protein GO:0007017//GO:0006281//GO:0007018 microtubule-based process//DNA repair//microtubule-based movement GO:0046872//GO:0008017//GO:0008270//GO:0003777//GO:0005524 metal ion binding//microtubule binding//zinc ion binding//microtubule motor activity//ATP binding GO:0045298//GO:0005874//GO:0019028//GO:0005634 tubulin complex//microtubule//viral capsid//nucleus -- -- Cluster-8309.52834 BF_2 9.77 0.42 1257 642932902 XP_008197179.1 985 4.9e-104 PREDICTED: carboxypeptidase M isoform X2 [Tribolium castaneum] -- -- -- -- -- K01296 CPM carboxypeptidase M http://www.genome.jp/dbget-bin/www_bget?ko:K01296 P14384 449 2.9e-43 Carboxypeptidase M OS=Homo sapiens GN=CPM PE=1 SV=2 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- KOG2649 Zinc carboxypeptidase Cluster-8309.52835 BF_2 177.15 6.99 1347 642912083 XP_008200795.1 598 4.0e-59 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- F1MLX5 162 5.9e-10 Leucine-rich repeat-containing G-protein coupled receptor 4 OS=Bos taurus GN=LGR4 PE=3 SV=3 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52836 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52837 BF_2 39.08 0.38 4552 560124991 CDJ90379.1 550 5.0e-53 uncharacterized protein LOC100903664 [Haemonchus contortus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11803//PF05970//PF02562 UDP-glucuronate decarboxylase N-terminal//PIF1-like helicase//PhoH-like protein GO:0005985//GO:0005982//GO:0006281//GO:0009117//GO:0000723 sucrose metabolic process//starch metabolic process//DNA repair//nucleotide metabolic process//telomere maintenance GO:0005524//GO:0003678//GO:0048040 ATP binding//DNA helicase activity//UDP-glucuronate decarboxylase activity GO:0005657 replication fork -- -- Cluster-8309.52838 BF_2 12.67 0.82 936 189236619 XP_001816527.1 588 4.0e-58 PREDICTED: N-alpha-acetyltransferase 20 [Tribolium castaneum]>gi|270005230|gb|EFA01678.1| hypothetical protein TcasGA2_TC007251 [Tribolium castaneum] 572306440 XM_006619049.1 99 3.82611e-42 PREDICTED: Apis dorsata N-alpha-acetyltransferase 20-like (LOC102677987), transcript variant X1, mRNA K17972 NAA20, NAT3 N-terminal acetyltransferase B complex catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17972 Q58ED9 453 7.4e-44 N-alpha-acetyltransferase 20 OS=Danio rerio GN=naa20 PE=2 SV=1 PF00583//PF13508//PF13673//PF08445 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3234 Acetyltransferase, (GNAT) family Cluster-8309.52839 BF_2 2.00 0.51 450 642933000 XP_008197222.1 477 1.4e-45 PREDICTED: dynein heavy chain 3, axonemal [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q8BW94 250 1.2e-20 Dynein heavy chain 3, axonemal OS=Mus musculus GN=Dnah3 PE=2 SV=2 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.52843 BF_2 20.00 0.43 2255 646720121 KDR21968.1 1734 1.3e-190 Protein henna [Zootermopsis nevadensis] 158294631 XM_315721.4 287 2.91839e-146 Anopheles gambiae str. PEST AGAP005712-PC (AgaP_AGAP005712) mRNA, complete cds K00500 phhA, PAH phenylalanine-4-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00500 P17276 1634 2.0e-180 Protein henna OS=Drosophila melanogaster GN=Hn PE=2 SV=3 PF01842//PF00351 ACT domain//Biopterin-dependent aromatic amino acid hydroxylase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016714//GO:0016597 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen//amino acid binding -- -- KOG3820 Aromatic amino acid hydroxylase Cluster-8309.52845 BF_2 349.45 8.50 2006 189241120 XP_973128.2 1177 4.3e-126 PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935513|ref|XP_008198040.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935515|ref|XP_008198041.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K17617 CTDNEP1, DULLARD, NEM1 CTD nuclear envelope phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17617 Q9VRG7 961 2.0e-102 CTD nuclear envelope phosphatase 1 homolog OS=Drosophila melanogaster GN=Dd PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.52846 BF_2 262.11 5.18 2403 91087247 XP_975518.1 1185 6.1e-127 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DCX5 279 2.9e-23 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690//PF03137 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.52848 BF_2 222.53 2.75 3671 642930167 XP_008196281.1 2996 0.0e+00 PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930169|ref|XP_008196282.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930171|ref|XP_008196283.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930173|ref|XP_008196284.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum]>gi|642930175|ref|XP_008196285.1| PREDICTED: high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3 [Tribolium castaneum] -- -- -- -- -- K18437 PDE8 high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18437 E9Q4S1 1519 7.1e-167 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B OS=Mus musculus GN=Pde8b PE=2 SV=1 PF00072//PF00989//PF09771//PF00233//PF05504 Response regulator receiver domain//PAS fold//Transmembrane protein 188//3'5'-cyclic nucleotide phosphodiesterase//Spore germination B3/ GerAC like, C-terminal GO:0009847//GO:0006355//GO:0006144//GO:0007165//GO:0035307//GO:0000160 spore germination//regulation of transcription, DNA-templated//purine nucleobase metabolic process//signal transduction//positive regulation of protein dephosphorylation//phosphorelay signal transduction system GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity GO:0071595//GO:0016020 Nem1-Spo7 phosphatase complex//membrane KOG3689 Cyclic nucleotide phosphodiesterase Cluster-8309.52849 BF_2 526.64 2.86 7988 242008211 XP_002424904.1 2464 1.0e-274 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 1.1e-148 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF13912//PF14764//PF06467 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//AP-5 complex subunit, vesicle trafficking//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0005488//GO:0008270 metal ion binding//binding//zinc ion binding GO:0044599 AP-5 adaptor complex -- -- Cluster-8309.52850 BF_2 201.70 3.36 2801 478254777 ENN75013.1 924 1.3e-96 hypothetical protein YQE_08329, partial [Dendroctonus ponderosae] -- -- -- -- -- K11536 SLC28A pyrimidine nucleoside transport protein http://www.genome.jp/dbget-bin/www_bget?ko:K11536 Q62773 538 3.1e-53 Sodium/nucleoside cotransporter 2 OS=Rattus norvegicus GN=Slc28a2 PE=1 SV=1 PF03577 Peptidase family C69 GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- KOG3747 Concentrative Na+-nucleoside cotransporter CNT1/CNT2 Cluster-8309.52852 BF_2 12.03 0.36 1674 780704567 XP_011702891.1 953 3.4e-100 PREDICTED: probable G-protein coupled receptor No9 isoform X2 [Wasmannia auropunctata] -- -- -- -- -- K04135 ADRA1A adrenergic receptor alpha-1A http://www.genome.jp/dbget-bin/www_bget?ko:K04135 P35348 514 1.1e-50 Alpha-1A adrenergic receptor OS=Homo sapiens GN=ADRA1A PE=1 SV=2 PF00001//PF01498 7 transmembrane receptor (rhodopsin family)//Transposase GO:0006313//GO:0015074//GO:0007186 transposition, DNA-mediated//DNA integration//G-protein coupled receptor signaling pathway GO:0003677//GO:0004930 DNA binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.52855 BF_2 138.08 2.66 2461 270015480 EFA11928.1 1006 3.6e-106 hypothetical protein TcasGA2_TC004274 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 459 3.9e-44 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF03708//PF04101//PF00201 Avian retrovirus envelope protein, gp85//Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups GO:0019031 viral envelope -- -- Cluster-8309.52856 BF_2 7.12 0.55 829 170028319 XP_001842043.1 190 5.0e-12 conserved hypothetical protein [Culex quinquefasciatus]>gi|167874198|gb|EDS37581.1| conserved hypothetical protein [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52864 BF_2 90.31 1.31 3166 642910366 XP_008200294.1 3475 0.0e+00 PREDICTED: myosin-IB [Tribolium castaneum]>gi|270014945|gb|EFA11393.1| hypothetical protein TcasGA2_TC011553 [Tribolium castaneum] 637314166 XM_008113233.1 58 8.21479e-19 PREDICTED: Anolis carolinensis myosin ID (myo1d), transcript variant X2, mRNA K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23979 2752 6.5e-310 Myosin-IB OS=Drosophila melanogaster GN=Myo61F PE=1 SV=3 PF06017//PF00612//PF00063 Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Myosin head (motor domain) -- -- GO:0005524//GO:0003774//GO:0005515 ATP binding//motor activity//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.52867 BF_2 354.89 4.55 3552 91080057 XP_973322.1 1495 1.0e-162 PREDICTED: GDP-mannose 4,6 dehydratase [Tribolium castaneum]>gi|270004634|gb|EFA01082.1| hypothetical protein TcasGA2_TC004005 [Tribolium castaneum] -- -- -- -- -- K01711 gmd, GMDS GDPmannose 4,6-dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01711 Q9VMW9 1339 5.1e-146 GDP-mannose 4,6 dehydratase OS=Drosophila melanogaster GN=Gmd PE=1 SV=2 PF01370 NAD dependent epimerase/dehydratase family GO:0019673//GO:0009298//GO:0006012//GO:0006000 GDP-mannose metabolic process//GDP-mannose biosynthetic process//galactose metabolic process//fructose metabolic process GO:0003824//GO:0050662//GO:0008446//GO:0000166 catalytic activity//coenzyme binding//GDP-mannose 4,6-dehydratase activity//nucleotide binding GO:0005622 intracellular KOG1372 GDP-mannose 4,6 dehydratase Cluster-8309.52869 BF_2 18.47 0.31 2811 91080613 XP_974147.1 1046 9.3e-111 PREDICTED: exosome complex component rrp45 [Tribolium castaneum]>gi|270005510|gb|EFA01958.1| hypothetical protein TcasGA2_TC007574 [Tribolium castaneum] 242003302 XM_002422642.1 81 1.19312e-31 Pediculus humanus corporis histone deacetylase complex subunit SAP30, putative, mRNA K03678 RRP45, EXOSC9 exosome complex component RRP45 http://www.genome.jp/dbget-bin/www_bget?ko:K03678 Q4QR75 691 5.6e-71 Exosome complex component RRP45 OS=Rattus norvegicus GN=Exosc9 PE=2 SV=1 PF13867 Sin3 binding region of histone deacetylase complex subunit SAP30 -- -- GO:0005515 protein binding -- -- KOG1614 Exosomal 3'-5' exoribonuclease complex, subunit Rrp45 Cluster-8309.52871 BF_2 154.93 0.80 8419 270015299 EFA11747.1 1763 2.0e-193 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 594 3.0e-59 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF16656//PF13895//PF00041 Purple acid Phosphatase, N-terminal domain//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.52879 BF_2 13.97 1.29 740 348041254 NP_001231682.1 1066 1.2e-113 low affinity immunoglobulin gamma Fc region receptor III-B isoform 1 [Homo sapiens] 348041253 NM_001244753.1 622 0 Homo sapiens Fc fragment of IgG, low affinity IIIb, receptor (CD16b) (FCGR3B), transcript variant 1, mRNA K06463 FCGR3, CD16 low affinity immunoglobulin gamma Fc region receptor III http://www.genome.jp/dbget-bin/www_bget?ko:K06463 O75015 974 2.3e-104 Low affinity immunoglobulin gamma Fc region receptor III-B OS=Homo sapiens GN=FCGR3B PE=1 SV=2 PF13895//PF02285 Immunoglobulin domain//Cytochrome oxidase c subunit VIII GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0005515//GO:0004129 protein binding//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.52880 BF_2 7.00 4.40 349 528755035 EPY74694.1 200 1.4e-13 fibroblast growth factor receptor 2 isoform 13 [Camelus ferus] 254553324 NG_012449.1 349 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21803 195 2.3e-14 Fibroblast growth factor receptor 2 OS=Mus musculus GN=Fgfr2 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52881 BF_2 28.01 1.55 1042 478255178 ENN75407.1 413 8.7e-38 hypothetical protein YQE_07958, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9DAK4 165 2.1e-10 Fatty acid-binding protein 12 OS=Mus musculus GN=Fabp12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4015 Fatty acid-binding protein FABP Cluster-8309.52882 BF_2 127.99 4.96 1366 642936649 XP_008198523.1 1499 1.3e-163 PREDICTED: 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial [Tribolium castaneum]>gi|270013058|gb|EFA09506.1| hypothetical protein TcasGA2_TC011607 [Tribolium castaneum] -- -- -- -- -- K09458 fabF 3-oxoacyl- http://www.genome.jp/dbget-bin/www_bget?ko:K09458 Q0VCA7 1115 1.9e-120 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial OS=Bos taurus GN=OXSM PE=2 SV=1 PF00108 Thiolase, N-terminal domain GO:0008152 metabolic process GO:0016740//GO:0016747 transferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG1394 3-oxoacyl-(acyl-carrier-protein) synthase (I and II) Cluster-8309.52885 BF_2 336.58 2.18 6760 189238206 XP_969047.2 3357 0.0e+00 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum] 512920866 XM_004929683.1 38 2.31429e-07 PREDICTED: Bombyx mori bumetanide-sensitive sodium-(potassium)-chloride cotransporter-like (LOC101736988), partial mRNA K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 2236 9.5e-250 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF13520//PF02786//PF00324//PF03522 Amino acid permease//Carbamoyl-phosphate synthase L chain, ATP binding domain//Amino acid permease//Solute carrier family 12 GO:0006865//GO:0055085//GO:0006810//GO:0003333//GO:0006811 amino acid transport//transmembrane transport//transport//amino acid transmembrane transport//ion transport GO:0005524//GO:0015171//GO:0005215 ATP binding//amino acid transmembrane transporter activity//transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.52894 BF_2 30.03 2.04 902 91095259 XP_973683.1 354 5.2e-31 PREDICTED: senecionine N-oxygenase [Tribolium castaneum]>gi|270017047|gb|EFA13493.1| hypothetical protein TcasGA2_TC016303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MP06 227 1.1e-17 Senecionine N-oxygenase OS=Tyria jacobaeae GN=sno1 PE=1 SV=1 PF00743//PF07992//PF02789 Flavin-binding monooxygenase-like//Pyridine nucleotide-disulphide oxidoreductase//Cytosol aminopeptidase family, N-terminal domain GO:0006508//GO:0055114 proteolysis//oxidation-reduction process GO:0050660//GO:0000166//GO:0004177//GO:0050661//GO:0004499//GO:0050662//GO:0016491//GO:0004497 flavin adenine dinucleotide binding//nucleotide binding//aminopeptidase activity//NADP binding//N,N-dimethylaniline monooxygenase activity//coenzyme binding//oxidoreductase activity//monooxygenase activity GO:0005622 intracellular KOG1399 Flavin-containing monooxygenase Cluster-8309.52896 BF_2 453.39 2.51 7832 642929402 XP_008195823.1 7413 0.0e+00 PREDICTED: unconventional myosin-Va isoform X2 [Tribolium castaneum] 766917087 XM_011503499.1 99 3.30337e-41 PREDICTED: Ceratosolen solmsi marchali unconventional myosin-Va (LOC105365325), mRNA K10357 MYO5 myosin V http://www.genome.jp/dbget-bin/www_bget?ko:K10357 Q9QYF3 4232 0.0e+00 Unconventional myosin-Va OS=Rattus norvegicus GN=Myo5a PE=1 SV=1 PF05902//PF01890//PF00612//PF00063//PF00584//PF11857//PF08437 4.1 protein C-terminal domain (CTD)//Cobalamin synthesis G C-terminus//IQ calmodulin-binding motif//Myosin head (motor domain)//SecE/Sec61-gamma subunits of protein translocation complex//Domain of unknown function (DUF3377)//Glycosyl transferase family 8 C-terminal GO:0009103//GO:0006605//GO:0006886//GO:0009236 lipopolysaccharide biosynthetic process//protein targeting//intracellular protein transport//cobalamin biosynthetic process GO:0005524//GO:0004222//GO:0005198//GO:0005515//GO:0003779//GO:0003774//GO:0008918 ATP binding//metalloendopeptidase activity//structural molecule activity//protein binding//actin binding//motor activity//lipopolysaccharide 3-alpha-galactosyltransferase activity GO:0016459//GO:0005856//GO:0016020 myosin complex//cytoskeleton//membrane KOG0160 Myosin class V heavy chain Cluster-8309.52898 BF_2 277.18 17.71 942 478263101 ENN81494.1 294 4.9e-24 hypothetical protein YQE_02023, partial [Dendroctonus ponderosae]>gi|546675484|gb|ERL86669.1| hypothetical protein D910_04075 [Dendroctonus ponderosae] -- -- -- -- -- K13120 FAM32A protein FAM32A http://www.genome.jp/dbget-bin/www_bget?ko:K13120 B0JZ89 231 4.1e-18 Protein FAM32A OS=Xenopus tropicalis GN=fam32a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3410 Conserved alpha-helical protein Cluster-8309.52899 BF_2 49.82 3.90 821 478263101 ENN81494.1 294 4.3e-24 hypothetical protein YQE_02023, partial [Dendroctonus ponderosae]>gi|546675484|gb|ERL86669.1| hypothetical protein D910_04075 [Dendroctonus ponderosae] -- -- -- -- -- K13120 FAM32A protein FAM32A http://www.genome.jp/dbget-bin/www_bget?ko:K13120 B0JZ89 231 3.6e-18 Protein FAM32A OS=Xenopus tropicalis GN=fam32a PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3410 Conserved alpha-helical protein Cluster-8309.52903 BF_2 24.11 0.65 1844 642917401 XP_008191181.1 1711 4.7e-188 PREDICTED: D-2-hydroxyglutarate dehydrogenase, mitochondrial-like [Tribolium castaneum] 167777849 CP000786.1 38 6.23112e-08 Leptospira biflexa serovar Patoc strain 'Patoc 1 (Paris)' chromosome I, complete sequence -- -- -- -- A1L258 1469 2.3e-161 D-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Danio rerio GN=d2hgdh PE=2 SV=1 PF01565//PF02913 FAD binding domain//FAD linked oxidases, C-terminal domain GO:0055114 oxidation-reduction process GO:0003824//GO:0050660//GO:0016491 catalytic activity//flavin adenine dinucleotide binding//oxidoreductase activity -- -- KOG1232 Proteins containing the FAD binding domain Cluster-8309.52908 BF_2 28.47 0.65 2110 546676350 ERL87377.1 1897 1.5e-209 hypothetical protein D910_04772 [Dendroctonus ponderosae] 642918185 XM_008193179.1 528 0 PREDICTED: Tribolium castaneum cyclin-dependent kinase 14 (LOC657012), transcript variant X2, mRNA K08821 CDK14, PFTK1 cyclin-dependent kinase 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08821 A4IIW7 1159 2.3e-125 Cyclin-dependent kinase 14 OS=Xenopus tropicalis GN=cdk14 PE=2 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.52910 BF_2 172.00 2.74 2916 270003257 EEZ99704.1 1989 4.4e-220 hypothetical protein TcasGA2_TC002465 [Tribolium castaneum] 170061339 XM_001866158.1 38 9.91707e-08 Culex quinquefasciatus lysosomal alpha-mannosidase, mRNA K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 Q29451 1437 1.8e-157 Lysosomal alpha-mannosidase OS=Bos taurus GN=MAN2B1 PE=1 SV=4 PF09261//PF07748//PF01074 Alpha mannosidase, middle domain//Glycosyl hydrolases family 38 C-terminal domain//Glycosyl hydrolases family 38 N-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0004553//GO:0008270//GO:0015923//GO:0004559 hydrolase activity, hydrolyzing O-glycosyl compounds//zinc ion binding//mannosidase activity//alpha-mannosidase activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.52911 BF_2 205.00 10.93 1072 270016479 EFA12925.1 311 6.0e-26 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00690 174 1.9e-11 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52912 BF_2 65.38 1.74 1858 807028462 XP_012157237.1 283 1.8e-22 PREDICTED: perlucin [Ceratitis capitata] -- -- -- -- -- -- -- -- -- P82596 192 2.7e-13 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4297 C-type lectin Cluster-8309.52913 BF_2 152.62 4.02 1877 807028462 XP_012157237.1 283 1.9e-22 PREDICTED: perlucin [Ceratitis capitata] -- -- -- -- -- -- -- -- -- P82596 192 2.7e-13 Perlucin OS=Haliotis laevigata PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4297 C-type lectin Cluster-8309.52914 BF_2 31.73 0.48 3057 642912407 XP_008199495.1 2146 2.9e-238 PREDICTED: liprin-alpha-1 isoform X13 [Tribolium castaneum] 642912406 XM_008201273.1 455 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X13, mRNA -- -- -- -- O75334 743 5.7e-77 Liprin-alpha-2 OS=Homo sapiens GN=PPFIA2 PE=1 SV=2 PF07536//PF02459 HWE histidine kinase//Adenoviral DNA terminal protein GO:0016310//GO:0006260 phosphorylation//DNA replication GO:0003677//GO:0004673 DNA binding//protein histidine kinase activity GO:0009365 protein histidine kinase complex KOG0249 LAR-interacting protein and related proteins Cluster-8309.52917 BF_2 352.10 3.34 4691 576249472 AHH29250.1 3252 0.0e+00 Bedraggled-like protein [Leptinotarsa decemlineata] 576249471 KC713792.1 606 0 Leptinotarsa decemlineata Bedraggled-like protein mRNA, complete cds K05336 SLC6AN solute carrier family 6 (neurotransmitter transporter), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05336 Q99884 256 2.6e-20 Sodium-dependent proline transporter OS=Homo sapiens GN=SLC6A7 PE=2 SV=2 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.52918 BF_2 127.32 5.39 1275 642929103 XP_008195691.1 371 7.9e-33 PREDICTED: uncharacterized protein LOC655454 [Tribolium castaneum]>gi|270010386|gb|EFA06834.1| hypothetical protein TcasGA2_TC009777 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52921 BF_2 71.00 7.19 700 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52923 BF_2 485.00 20.66 1269 642935282 XP_008197947.1 1110 1.6e-118 PREDICTED: malectin-B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8AVF4 670 6.9e-69 Malectin-B OS=Xenopus laevis GN=mlec-b PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3593 Predicted receptor-like serine/threonine kinase Cluster-8309.52925 BF_2 29.28 0.39 3430 642939832 XP_008190719.1 290 5.3e-23 PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum]>gi|642939834|ref|XP_008190783.1| PREDICTED: uncharacterized protein LOC661951 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AYP4 169 2.3e-10 Zinc finger C2HC domain-containing protein 1C OS=Rattus norvegicus GN=Zc2hc1c PE=2 SV=1 PF06689 ClpX C4-type zinc finger -- -- GO:0008270//GO:0046983 zinc ion binding//protein dimerization activity -- -- KOG3940 Uncharacterized conserved protein Cluster-8309.52926 BF_2 43.49 0.39 4991 102939 708 2.6e-71 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- P04323 517 1.5e-50 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF02251 Proteasome activator pa28 alpha subunit -- -- -- -- GO:0008537 proteasome activator complex -- -- Cluster-8309.52927 BF_2 48.16 0.36 5824 270015748 EFA12196.1 1249 5.6e-134 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 653 3.0e-66 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF11468//PF02156//PF13013//PF00665//PF13683 Aromatic prenyltransferase Orf2//Glycosyl hydrolase family 26//F-box-like domain//Integrase core domain//Integrase core domain GO:0015074//GO:0005975 DNA integration//carbohydrate metabolic process GO:0004553//GO:0016740//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//transferase activity//protein binding -- -- -- -- Cluster-8309.52928 BF_2 54.55 0.38 6371 270015748 EFA12196.1 1249 6.1e-134 hypothetical protein TcasGA2_TC004349 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 653 3.2e-66 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665//PF11468//PF02156//PF13013 Integrase core domain//Integrase core domain//Aromatic prenyltransferase Orf2//Glycosyl hydrolase family 26//F-box-like domain GO:0015074//GO:0005975 DNA integration//carbohydrate metabolic process GO:0004553//GO:0016740//GO:0005515 hydrolase activity, hydrolyzing O-glycosyl compounds//transferase activity//protein binding -- -- -- -- Cluster-8309.52929 BF_2 3.00 0.84 436 478257487 ENN77643.1 316 6.4e-27 hypothetical protein YQE_05937, partial [Dendroctonus ponderosae]>gi|546679880|gb|ERL90268.1| hypothetical protein D910_07620 [Dendroctonus ponderosae] -- -- -- -- -- K01326 CELA1 pancreatic elastase I http://www.genome.jp/dbget-bin/www_bget?ko:K01326 P00771 206 1.5e-15 Brachyurin OS=Uca pugilator PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.52932 BF_2 95.43 2.24 2067 91082233 XP_972708.1 1766 2.2e-194 PREDICTED: 2',5'-phosphodiesterase 12 [Tribolium castaneum]>gi|270007451|gb|EFA03899.1| hypothetical protein TcasGA2_TC014029 [Tribolium castaneum] 752886955 XM_011263028.1 45 8.99027e-12 PREDICTED: Camponotus floridanus 2',5'-phosphodiesterase 12-like (LOC105254385), partial mRNA K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q6AXQ5 989 1.2e-105 2',5'-phosphodiesterase 12 OS=Rattus norvegicus GN=Pde12 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.52934 BF_2 175.32 3.67 2287 642917912 XP_008191379.1 958 1.2e-100 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q88168 536 4.3e-53 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.52936 BF_2 479.79 5.76 3774 91091180 XP_971767.1 1087 2.2e-115 PREDICTED: uncharacterized protein LOC660444 [Tribolium castaneum]>gi|270013120|gb|EFA09568.1| hypothetical protein TcasGA2_TC011682 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VCH8 313 5.1e-27 Transmembrane protein 65 OS=Bos taurus GN=TMEM65 PE=2 SV=1 PF01293 Phosphoenolpyruvate carboxykinase GO:0015976//GO:0006099//GO:0006094 carbon utilization//tricarboxylic acid cycle//gluconeogenesis GO:0005524//GO:0004612 ATP binding//phosphoenolpyruvate carboxykinase (ATP) activity -- -- KOG4619 Uncharacterized conserved protein Cluster-8309.52938 BF_2 61.76 0.51 5355 478251798 ENN72244.1 2578 4.0e-288 hypothetical protein YQE_11107, partial [Dendroctonus ponderosae] 642923087 XM_967659.3 120 4.77829e-53 PREDICTED: Tribolium castaneum hemocyte protein-glutamine gamma-glutamyltransferase (LOC661504), mRNA K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1770 8.2e-196 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00868//PF00927 Transglutaminase family//Transglutaminase family, C-terminal ig like domain GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.5294 BF_2 74.43 14.69 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52940 BF_2 456.10 3.83 5273 478251798 ENN72244.1 2578 4.0e-288 hypothetical protein YQE_11107, partial [Dendroctonus ponderosae] 642923087 XM_967659.3 120 4.70462e-53 PREDICTED: Tribolium castaneum hemocyte protein-glutamine gamma-glutamyltransferase (LOC661504), mRNA K05619 TGM1 transglutaminase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05619 Q05187 1770 8.1e-196 Hemocyte protein-glutamine gamma-glutamyltransferase OS=Tachypleus tridentatus PE=1 SV=1 PF00927//PF00868 Transglutaminase family, C-terminal ig like domain//Transglutaminase family GO:0018149 peptide cross-linking GO:0003810 protein-glutamine gamma-glutamyltransferase activity -- -- -- -- Cluster-8309.52945 BF_2 130.76 11.52 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52949 BF_2 13.07 0.49 1405 642927818 XP_008195414.1 1287 5.3e-139 PREDICTED: zinc finger FYVE domain-containing protein 19 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96K21 212 9.8e-16 Abscission/NoCut checkpoint regulator OS=Homo sapiens GN=ZFYVE19 PE=1 SV=3 PF00643//PF01363 B-box zinc finger//FYVE zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.5295 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52951 BF_2 1.10 1.21 313 270004866 EFA01314.1 176 7.9e-11 angiopoietin-like 1 precursor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2AV25 137 1.1e-07 Fibrinogen C domain-containing protein 1 OS=Mus musculus GN=Fibcd1 PE=2 SV=1 PF14672 Late cornified envelope GO:0008544 epidermis development -- -- -- -- -- -- Cluster-8309.52954 BF_2 212.99 2.21 4313 642919433 XP_008191867.1 1035 2.7e-109 PREDICTED: uncharacterized protein LOC663349 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09197//PF04272 Rap1, DNA-binding//Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0003677//GO:0005246//GO:0042030 DNA binding//calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.52955 BF_2 114.39 1.61 3256 91088973 XP_966480.1 3004 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 642932569 XM_961387.2 783 0 PREDICTED: Tribolium castaneum G protein-coupled receptor kinase 1 (LOC654946), mRNA K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2673 9.7e-301 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF07714//PF00069//PF06293//PF01160 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Vertebrate endogenous opioids neuropeptide GO:0038032//GO:0009069//GO:0006468//GO:0016310//GO:0007218 termination of G-protein coupled receptor signaling pathway//serine family amino acid metabolic process//protein phosphorylation//phosphorylation//neuropeptide signaling pathway GO:0005524//GO:0016773//GO:0004703//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//G-protein coupled receptor kinase activity//protein kinase activity GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.52958 BF_2 54.46 3.06 1031 332376963 AEE63621.1 661 1.5e-66 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13220 WBP4, FBP21 WW domain-binding protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13220 Q5HZF2 177 8.2e-12 WW domain-binding protein 4 OS=Rattus norvegicus GN=Wbp4 PE=2 SV=1 PF00397//PF06220 WW domain//U1 zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- KOG0150 Spliceosomal protein FBP21 Cluster-8309.5296 BF_2 5.57 0.52 734 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52961 BF_2 1.00 0.37 398 478253166 ENN73537.1 194 8.2e-13 hypothetical protein YQE_09788, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7KQZ4 154 1.5e-09 Longitudinals lacking protein, isoforms A/B/D/L OS=Drosophila melanogaster GN=lola PE=1 SV=1 PF00096//PF13465//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.52962 BF_2 103.00 2.64 1919 642920137 XP_008192221.1 399 6.7e-36 PREDICTED: zinc finger protein weckle-like [Tribolium castaneum]>gi|270005306|gb|EFA01754.1| hypothetical protein TcasGA2_TC007352 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08875 128 7.4e-06 Protein suppressor of hairy wing OS=Drosophila ananassae GN=su(Hw) PE=2 SV=1 PF02892//PF13465//PF00096 BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.52963 BF_2 1.00 0.51 366 546680101 ERL90442.1 191 1.7e-12 hypothetical protein D910_07791 [Dendroctonus ponderosae] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52964 BF_2 1.00 0.90 325 642926387 XP_008194904.1 173 1.8e-10 PREDICTED: centromere-associated protein E-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52967 BF_2 213.00 6.46 1667 499140776 AGL76355.1 420 2.2e-38 transposase [Drosophila buzzatii] -- -- -- -- -- -- -- -- -- Q7M3K2 261 2.4e-21 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52969 BF_2 103.98 4.05 1361 91079626 XP_967654.1 1329 6.9e-144 PREDICTED: 28S ribosomal protein S29, mitochondrial [Tribolium castaneum]>gi|270004472|gb|EFA00920.1| hypothetical protein TcasGA2_TC003826 [Tribolium castaneum] -- -- -- -- -- K17408 DAP3, MRPS29 small subunit ribosomal protein S29 http://www.genome.jp/dbget-bin/www_bget?ko:K17408 P82922 749 5.1e-78 28S ribosomal protein S29, mitochondrial OS=Bos taurus GN=DAP3 PE=1 SV=3 PF04659 Archaeal flagella protein GO:0006915//GO:0097588 apoptotic process//archaeal or bacterial-type flagellum-dependent cell motility -- -- GO:0005761//GO:0015935 mitochondrial ribosome//small ribosomal subunit KOG3928 Mitochondrial ribosome small subunit component, mediator of apoptosis DAP3 Cluster-8309.52970 BF_2 7.00 4.91 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.52971 BF_2 92.12 2.06 2160 91089481 XP_969353.1 1438 2.5e-156 PREDICTED: beta-glucuronidase [Tribolium castaneum]>gi|270011394|gb|EFA07842.1| hypothetical protein TcasGA2_TC005412 [Tribolium castaneum] -- -- -- -- -- K01195 uidA, GUSB beta-glucuronidase http://www.genome.jp/dbget-bin/www_bget?ko:K01195 P06760 942 3.4e-100 Beta-glucuronidase OS=Rattus norvegicus GN=Gusb PE=2 SV=1 PF02836//PF00703//PF02837 Glycosyl hydrolases family 2, TIM barrel domain//Glycosyl hydrolases family 2//Glycosyl hydrolases family 2, sugar binding domain GO:0005975 carbohydrate metabolic process GO:0004553//GO:0003824 hydrolase activity, hydrolyzing O-glycosyl compounds//catalytic activity -- -- KOG2024 Beta-Glucuronidase GUSB (glycosylhydrolase superfamily 2) Cluster-8309.52972 BF_2 3.00 0.77 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07646 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52974 BF_2 25.06 0.72 1737 642919693 XP_008192024.1 250 1.2e-18 PREDICTED: transient receptor potential channel pyrexia-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0JKV1 129 5.1e-06 Potassium channel AKT1 OS=Oryza sativa subsp. japonica GN=AKT1 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.52977 BF_2 43.14 0.54 3660 642922790 XP_008193326.1 872 1.8e-90 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 469 4.0e-45 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 PF08923 Mitogen-activated protein kinase kinase 1 interacting GO:0032006 regulation of TOR signaling -- -- -- -- -- -- Cluster-8309.52979 BF_2 28.84 0.52 2590 270002254 EEZ98701.1 2172 2.3e-241 hypothetical protein TcasGA2_TC001240 [Tribolium castaneum] -- -- -- -- -- K10638 UHRF1, NP95 E3 ubiquitin-protein ligase UHRF1 http://www.genome.jp/dbget-bin/www_bget?ko:K10638 E7EZF3 1915 6.1e-213 E3 ubiquitin-protein ligase UHRF1 OS=Danio rerio GN=uhrf1 PE=1 SV=1 PF14634//PF00628//PF00240//PF00097//PF02182 zinc-RING finger domain//PHD-finger//Ubiquitin family//Zinc finger, C3HC4 type (RING finger)//SAD/SRA domain -- -- GO:0042393//GO:0008270//GO:0005515//GO:0046872 histone binding//zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.52981 BF_2 36.88 0.58 2935 805765285 XP_012134962.1 832 6.4e-86 PREDICTED: peptidyl-prolyl cis-trans isomerase cyp11 isoform X2 [Megachile rotundata] 645259408 XM_008237125.1 62 4.54687e-21 PREDICTED: Prunus mume peptidyl-prolyl cis-trans isomerase 8 (LOC103334184), transcript variant X3, mRNA K09566 PPIG peptidyl-prolyl isomerase G (cyclophilin G) http://www.genome.jp/dbget-bin/www_bget?ko:K09566 O55035 612 8.5e-62 Peptidyl-prolyl cis-trans isomerase G OS=Rattus norvegicus GN=Ppig PE=1 SV=2 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0000413//GO:0006457 protein peptidyl-prolyl isomerization//protein folding GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0546 HSP90 co-chaperone CPR7/Cyclophilin Cluster-8309.52988 BF_2 62.98 0.92 3159 557160153 CDJ27266.1 145 3.2e-06 hypothetical protein EMH_0030220 [Eimeria mitis] -- -- -- -- -- -- -- -- -- Q551H4 136 1.4e-06 Serine/threonine-protein kinase fray2 OS=Dictyostelium discoideum GN=fray2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.52991 BF_2 240.00 11.94 1128 546678608 ERL89190.1 666 4.3e-67 hypothetical protein D910_06564 [Dendroctonus ponderosae] -- -- -- -- -- K00943 tmk, DTYMK dTMP kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00943 P97930 524 5.2e-52 Thymidylate kinase OS=Mus musculus GN=Dtymk PE=2 SV=2 PF01637 Archaeal ATPase -- -- GO:0005524 ATP binding -- -- KOG3327 Thymidylate kinase/adenylate kinase Cluster-8309.52993 BF_2 375.05 3.89 4324 189236304 XP_975050.2 1063 1.5e-112 PREDICTED: alkaline phosphatase 4 [Tribolium castaneum]>gi|270005478|gb|EFA01926.1| hypothetical protein TcasGA2_TC007539 [Tribolium castaneum] 642919537 XM_969957.3 61 2.41889e-20 PREDICTED: Tribolium castaneum alkaline phosphatase 4 (LOC663929), mRNA K01077 E3.1.3.1, phoA, phoB alkaline phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01077 Q24238 697 1.7e-71 Alkaline phosphatase 4 OS=Drosophila melanogaster GN=Aph-4 PE=2 SV=3 PF00245//PF01676 Alkaline phosphatase//Metalloenzyme superfamily GO:0008152 metabolic process GO:0016791//GO:0046872//GO:0016787//GO:0003824 phosphatase activity//metal ion binding//hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.52996 BF_2 615.00 14.50 2061 478258663 ENN78713.1 496 4.1e-47 hypothetical protein YQE_04885, partial [Dendroctonus ponderosae]>gi|546674935|gb|ERL86212.1| hypothetical protein D910_03623 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53001 BF_2 52.01 0.33 6921 642920242 XP_008192264.1 3133 0.0e+00 PREDICTED: uncharacterized protein CG43867 isoform X2 [Tribolium castaneum] 194768448 XM_001966288.1 67 1.79343e-23 Drosophila ananassae GF22056 (Dana\GF22056), mRNA -- -- -- -- Q9W5D0 1421 3.1e-155 Uncharacterized protein CG43867 OS=Drosophila melanogaster GN=CG43867 PE=1 SV=4 PF00784//PF05864 MyTH4 domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005856//GO:0005730 cytoskeleton//nucleolus KOG0248 Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains Cluster-8309.53004 BF_2 2.00 1.24 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53006 BF_2 32.67 1.11 1514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53011 BF_2 33.02 1.11 1528 270010329 EFA06777.1 847 6.0e-88 hypothetical protein TcasGA2_TC009713 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BRG8 350 1.1e-31 Transmembrane protein 209 OS=Mus musculus GN=Tmem209 PE=2 SV=1 PF02602 Uroporphyrinogen-III synthase HemD GO:0033014//GO:0006783//GO:0015994 tetrapyrrole biosynthetic process//heme biosynthetic process//chlorophyll metabolic process GO:0004852 uroporphyrinogen-III synthase activity -- -- KOG4670 Uncharacterized conserved membrane protein Cluster-8309.53013 BF_2 12.00 0.35 1741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02822 Antistasin family -- -- GO:0004867 serine-type endopeptidase inhibitor activity -- -- -- -- Cluster-8309.53014 BF_2 29.86 0.64 2226 795017626 XP_011858919.1 264 3.5e-20 PREDICTED: uncharacterized protein LOC105556435, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53017 BF_2 136.86 7.38 1063 642927984 XP_008195472.1 432 5.6e-40 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53020 BF_2 19.54 1.01 1094 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF17097//PF06416 Spindle pole body component//Protein of unknown function (DUF1076) GO:0072519//GO:0016567 parasitism//protein ubiquitination GO:0004842 ubiquitin-protein transferase activity GO:0000775 chromosome, centromeric region -- -- Cluster-8309.53022 BF_2 173.24 7.13 1304 91078772 XP_966771.1 870 1.1e-90 PREDICTED: mitochondrial import receptor subunit TOM40 homolog 1 [Tribolium castaneum]>gi|270004110|gb|EFA00558.1| hypothetical protein TcasGA2_TC003426 [Tribolium castaneum] -- -- -- -- -- K11518 TOM40 mitochondrial import receptor subunit TOM40 http://www.genome.jp/dbget-bin/www_bget?ko:K11518 Q9U4L6 631 2.4e-64 Mitochondrial import receptor subunit TOM40 homolog 1 OS=Drosophila melanogaster GN=Tom40 PE=2 SV=2 PF01459 Eukaryotic porin GO:0006820//GO:0044070//GO:0055085 anion transport//regulation of anion transport//transmembrane transport GO:0008308 voltage-gated anion channel activity GO:0005741 mitochondrial outer membrane KOG3296 Translocase of outer mitochondrial membrane complex, subunit TOM40 Cluster-8309.53025 BF_2 55.15 0.87 2954 270001480 EEZ97927.1 555 8.5e-54 hypothetical protein TcasGA2_TC000314 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H5L6 192 4.3e-13 DNA transposase THAP9 OS=Homo sapiens GN=THAP9 PE=1 SV=2 PF01082//PF05485 Copper type II ascorbate-dependent monooxygenase, N-terminal domain//THAP domain GO:0055114 oxidation-reduction process GO:0016715//GO:0004497//GO:0005507//GO:0003676 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen//monooxygenase activity//copper ion binding//nucleic acid binding -- -- -- -- Cluster-8309.53028 BF_2 99.85 5.56 1038 546678378 ERL89011.1 847 4.1e-88 hypothetical protein D910_06389 [Dendroctonus ponderosae] -- -- -- -- -- K17231 IYD, DEHAL1 iodotyrosine deiodinase http://www.genome.jp/dbget-bin/www_bget?ko:K17231 Q6PHW0 713 5.8e-74 Iodotyrosine dehalogenase 1 OS=Homo sapiens GN=IYD PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3936 Nitroreductases Cluster-8309.53031 BF_2 306.00 2.52 5357 91094623 XP_969159.1 2619 7.1e-293 PREDICTED: SCY1-like protein 2 [Tribolium castaneum]>gi|270016433|gb|EFA12879.1| hypothetical protein TcasGA2_TC011557 [Tribolium castaneum] -- -- -- -- -- K17541 SCYL2 SCY1-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17541 Q6P3W7 1760 1.2e-194 SCY1-like protein 2 OS=Homo sapiens GN=SCYL2 PE=1 SV=1 PF00069//PF07776//PF07714//PF00096//PF16622//PF02985//PF13912//PF13465 Protein kinase domain//Zinc-finger associated domain (zf-AD)//Protein tyrosine kinase//Zinc finger, C2H2 type//zinc-finger C2H2-type//HEAT repeat//C2H2-type zinc finger//Zinc-finger double domain GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0046872//GO:0005524//GO:0008270 protein binding//protein kinase activity//metal ion binding//ATP binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.53038 BF_2 2.00 0.62 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53044 BF_2 18.00 1.82 700 6006555 CAB56793.1 1257 7.9e-136 proto-oncogene [Homo sapiens] 767947836 XM_011516223.1 700 0 PREDICTED: Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), transcript variant X1, mRNA K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2QLF1 1257 3.3e-137 Hepatocyte growth factor receptor OS=Pan troglodytes GN=MET PE=3 SV=1 PF01403 Sema domain -- -- GO:0005515 protein binding -- -- KOG3610 Plexins (functional semaphorin receptors) Cluster-8309.53045 BF_2 47.56 1.08 2132 642930929 XP_008196145.1 2008 2.0e-222 PREDICTED: ephrin type-B receptor 1-B isoform X1 [Tribolium castaneum] 642930930 XM_008197924.1 296 2.73726e-151 PREDICTED: Tribolium castaneum ephrin type-A receptor 4-B (LOC658635), transcript variant X2, mRNA K05110 EPHB1, ELK, NET Eph receptor B1 http://www.genome.jp/dbget-bin/www_bget?ko:K05110 P28693 772 1.7e-80 Ephrin type-B receptor 2 OS=Gallus gallus GN=EPHB2 PE=1 SV=3 PF01404//PF00041//PF16656 Ephrin receptor ligand binding domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0048013//GO:0006771//GO:0019497 ephrin receptor signaling pathway//riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0005515 acid phosphatase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.53047 BF_2 82.23 1.10 3417 546674875 ERL86161.1 2709 1.7e-303 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 825 2.0e-86 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF13855//PF00560//PF00595//PF13180 Leucine rich repeat//Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.53048 BF_2 140.00 5.42 1367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53049 BF_2 16.94 0.49 1736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53050 BF_2 71.06 1.21 2753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53053 BF_2 80.00 1.81 2136 642911027 XP_008193514.1 1859 3.8e-205 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7G192 756 1.2e-78 Indole-3-acetaldehyde oxidase OS=Arabidopsis thaliana GN=AAO2 PE=1 SV=2 PF00123//PF00941//PF01799//PF06056//PF00111 Peptide hormone//FAD binding domain in molybdopterin dehydrogenase//[2Fe-2S] binding domain//Putative ATPase subunit of terminase (gpP-like)//2Fe-2S iron-sulfur cluster binding domain GO:0006118//GO:0019069//GO:0055114//GO:0007165 obsolete electron transport//viral capsid assembly//oxidation-reduction process//signal transduction GO:0009055//GO:0051536//GO:0046872//GO:0005524//GO:0005179//GO:0016491 electron carrier activity//iron-sulfur cluster binding//metal ion binding//ATP binding//hormone activity//oxidoreductase activity GO:0005576 extracellular region -- -- Cluster-8309.53057 BF_2 2275.00 717.68 419 157129316 XP_001655365.1 163 3.4e-09 AAEL002467-PA [Aedes aegypti]>gi|108882100|gb|EAT46325.1| AAEL002467-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607//PF00020 Chitin binding Peritrophin-A domain//TNFR/NGFR cysteine-rich region GO:0006030 chitin metabolic process GO:0008061//GO:0005515 chitin binding//protein binding GO:0005576 extracellular region -- -- Cluster-8309.53058 BF_2 53.83 0.70 3506 728418700 AIY68378.1 1446 4.8e-157 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- A2RRT9 613 7.8e-62 Cytochrome P450 4V2 OS=Rattus norvegicus GN=Cyp4v2 PE=2 SV=1 PF07859//PF00326//PF00067 alpha/beta hydrolase fold//Prolyl oligopeptidase family//Cytochrome P450 GO:0008152//GO:0055114//GO:0006508 metabolic process//oxidation-reduction process//proteolysis GO:0016787//GO:0016705//GO:0008236//GO:0005506//GO:0020037 hydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//serine-type peptidase activity//iron ion binding//heme binding -- -- -- -- Cluster-8309.53063 BF_2 21.00 0.79 1401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53064 BF_2 6.00 3.45 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53065 BF_2 108.00 2.40 2167 820805572 AKG92777.1 698 1.6e-70 helix loop helix protein 3B [Leptinotarsa decemlineata] -- -- -- -- -- K09068 TAL T-cell acute lymphocytic leukemia protein http://www.genome.jp/dbget-bin/www_bget?ko:K09068 Q90YI8 262 2.4e-21 T-cell acute lymphocytic leukemia protein 1 OS=Takifugu rubripes GN=tal1 PE=2 SV=1 PF00010//PF06338 Helix-loop-helix DNA-binding domain//ComK protein GO:0030420 establishment of competence for transformation GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.53066 BF_2 16.62 0.93 1031 642940186 XP_008200539.1 953 2.1e-100 PREDICTED: uncharacterized protein LOC103314959 isoform X1 [Tribolium castaneum]>gi|642940188|ref|XP_008200548.1| PREDICTED: uncharacterized protein LOC103314959 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01609//PF13545 Transposase DDE domain//Crp-like helix-turn-helix domain GO:0006313//GO:0006355 transposition, DNA-mediated//regulation of transcription, DNA-templated GO:0004803//GO:0003677 transposase activity//DNA binding -- -- -- -- Cluster-8309.53069 BF_2 30.04 1.17 1357 189236439 XP_001814289.1 1012 3.9e-107 PREDICTED: uncharacterized protein LOC100142575 [Tribolium castaneum]>gi|270005928|gb|EFA02376.1| hypothetical protein TcasGA2_TC008051 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53071 BF_2 641.24 6.33 4524 795035143 XP_011864846.1 2194 1.1e-243 PREDICTED: serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform isoform X1 [Vollenhovia emeryi] 642933878 XM_008199327.1 658 0 PREDICTED: Tribolium castaneum protein phosphatase PP2A 55 kDa regulatory subunit (LOC659477), transcript variant X2, mRNA K04354 PPP2R2 serine/threonine-protein phosphatase 2A regulatory subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K04354 P36872 2065 4.3e-230 Protein phosphatase PP2A 55 kDa regulatory subunit OS=Drosophila melanogaster GN=tws PE=2 SV=1 PF11093//PF00400//PF13465//PF13463 Mitochondrial export protein Som1//WD domain, G-beta repeat//Zinc-finger double domain//Winged helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046872//GO:0003700 protein binding//metal ion binding//transcription factor activity, sequence-specific DNA binding GO:0042720//GO:0005667 mitochondrial inner membrane peptidase complex//transcription factor complex KOG1354 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.53074 BF_2 3.00 1.24 387 478268065 ENN83136.1 178 5.8e-11 hypothetical protein YQE_00503, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53076 BF_2 29.35 1.39 1169 642925968 XP_008194714.1 549 1.7e-53 PREDICTED: uncharacterized protein LOC655532 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53077 BF_2 264.05 5.41 2328 642925968 XP_008194714.1 817 2.8e-84 PREDICTED: uncharacterized protein LOC655532 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53078 BF_2 12.20 0.42 1505 642928334 XP_008195539.1 226 6.1e-16 PREDICTED: lysozyme-like [Tribolium castaneum] 332373991 BT127175.1 47 5.02773e-13 Dendroctonus ponderosae clone DPO0418_A10 unknown mRNA K01185 E3.2.1.17 lysozyme http://www.genome.jp/dbget-bin/www_bget?ko:K01185 P48816 155 4.3e-09 Lysozyme OS=Bombyx mori PE=1 SV=1 PF01160 Vertebrate endogenous opioids neuropeptide GO:0007218 neuropeptide signaling pathway -- -- -- -- -- -- Cluster-8309.53079 BF_2 63.57 0.53 5286 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.3e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.53081 BF_2 469.01 4.24 4915 478252864 ENN73253.1 1822 1.7e-200 hypothetical protein YQE_10149, partial [Dendroctonus ponderosae] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1237 4.8e-134 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.53088 BF_2 4.06 0.52 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53090 BF_2 30.87 0.59 2487 91092922 XP_975933.1 556 5.4e-54 PREDICTED: uncharacterized protein LOC660277 [Tribolium castaneum]>gi|270003110|gb|EEZ99557.1| hypothetical protein TcasGA2_TC000139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53091 BF_2 25.63 0.34 3423 817213310 XP_012282872.1 1421 3.7e-154 PREDICTED: POU domain, class 6, transcription factor 1 isoform X2 [Orussus abietinus] 817056495 XM_012413689.1 107 5.12764e-46 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 671 1.4e-68 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00157//PF00046 Pou domain - N-terminal to homeobox domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3802 Transcription factor OCT-1, contains POU and HOX domains Cluster-8309.53094 BF_2 195.73 1.53 5643 270006808 EFA03256.1 1963 8.7e-217 hypothetical protein TcasGA2_TC013190 [Tribolium castaneum] 642924343 XM_008196035.1 453 0 PREDICTED: Tribolium castaneum voltage-gated potassium channel subunit beta-2 (LOC658668), mRNA K04883 KCNAB2 potassium voltage-gated channel Shaker-related subfamily A, beta member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04883 Q27955 988 4.1e-105 Voltage-gated potassium channel subunit beta-2 OS=Bos taurus GN=KCNAB2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1575 Voltage-gated shaker-like K+ channel, subunit beta/KCNAB Cluster-8309.53099 BF_2 14.63 0.46 1613 642921119 XP_975344.2 289 3.2e-23 PREDICTED: sphingomyelin phosphodiesterase-like [Tribolium castaneum]>gi|270006197|gb|EFA02645.1| hypothetical protein TcasGA2_TC008366 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.531 BF_2 33.00 2.52 836 332374752 AEE62517.1 280 1.8e-22 unknown [Dendroctonus ponderosae]>gi|478256059|gb|ENN76258.1| hypothetical protein YQE_07223, partial [Dendroctonus ponderosae]>gi|546675990|gb|ERL87085.1| hypothetical protein D910_04486 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P49100 215 2.6e-16 Cytochrome b5 OS=Oryza sativa subsp. japonica GN=Os05g0108800 PE=2 SV=2 PF09187 Domain of unknown function(DUF1950) GO:0044030 regulation of DNA methylation -- -- GO:0005634 nucleus KOG0537 Cytochrome b5 Cluster-8309.53100 BF_2 27.00 0.48 2623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53107 BF_2 49.00 2.02 1304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04879 Molybdopterin oxidoreductase Fe4S4 domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.53110 BF_2 4.00 0.56 586 546683574 ERL93372.1 461 1.3e-43 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- K09641 TMPRSS11D transmembrane protease, serine 11D http://www.genome.jp/dbget-bin/www_bget?ko:K09641 Q00871 324 4.2e-29 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.53111 BF_2 53.33 1.14 2249 642919263 XP_008191800.1 1580 9.0e-173 PREDICTED: bestrophin-2 [Tribolium castaneum]>gi|270005766|gb|EFA02214.1| hypothetical protein TcasGA2_TC007873 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BGM5 945 1.6e-100 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 PF08283 Geminivirus rep protein central domain GO:0006308 DNA catabolic process GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.53117 BF_2 106.37 1.13 4238 332376687 AEE63483.1 502 1.7e-47 unknown [Dendroctonus ponderosae]>gi|478259424|gb|ENN79314.1| hypothetical protein YQE_04223, partial [Dendroctonus ponderosae]>gi|546675165|gb|ERL86401.1| hypothetical protein D910_03808 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VWK6 326 1.8e-28 Post-GPI attachment to proteins factor 2-like OS=Drosophila melanogaster GN=CG7990 PE=2 SV=4 -- -- -- -- -- -- -- -- KOG3979 FGF receptor activating protein 1 Cluster-8309.53118 BF_2 72.24 1.46 2355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53119 BF_2 49.76 1.90 1385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53122 BF_2 18.68 1.18 951 795010007 XP_011864749.1 696 1.2e-70 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.53126 BF_2 52.57 5.47 689 546675653 ERL86803.1 445 1.1e-41 hypothetical protein D910_04208 [Dendroctonus ponderosae] -- -- -- -- -- K13863 SLC7A1, ATRC1 solute carrier family 7 (cationic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13863 O08812 220 5.7e-17 Cationic amino acid transporter 3 OS=Rattus norvegicus GN=Slc7a3 PE=2 SV=1 PF03840//PF03419 Preprotein translocase SecG subunit//Sporulation factor SpoIIGA GO:0015031//GO:0030436//GO:0006508//GO:0009306 protein transport//asexual sporulation//proteolysis//protein secretion GO:0015450//GO:0004190 P-P-bond-hydrolysis-driven protein transmembrane transporter activity//aspartic-type endopeptidase activity GO:0009941//GO:0016021 chloroplast envelope//integral component of membrane KOG1286 Amino acid transporters Cluster-8309.53128 BF_2 167.77 4.79 1753 642926638 XP_008194951.1 1549 2.7e-169 PREDICTED: LOW QUALITY PROTEIN: DNA-binding protein Ets97D [Tribolium castaneum] -- -- -- -- -- K09441 GABPA GA-binding protein transcription factor, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K09441 Q04688 944 1.6e-100 DNA-binding protein Ets97D OS=Drosophila melanogaster GN=Ets97D PE=1 SV=2 PF02198//PF00178 Sterile alpha motif (SAM)/Pointed domain//Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG3806 Predicted transcription factor Cluster-8309.5313 BF_2 21.76 0.37 2746 332374612 AEE62447.1 1251 1.5e-134 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 756 1.6e-78 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.53130 BF_2 236.01 18.49 821 546680452 ERL90718.1 468 2.9e-44 hypothetical protein D910_08065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16740 Spindle and kinetochore-associated protein 2 GO:0007059//GO:0031110//GO:0051301//GO:0007067//GO:0000090 chromosome segregation//regulation of microtubule polymerization or depolymerization//cell division//mitotic nuclear division//mitotic anaphase GO:0008017 microtubule binding GO:0005876//GO:0000940//GO:0045298 spindle microtubule//condensed chromosome outer kinetochore//tubulin complex -- -- Cluster-8309.53133 BF_2 639.80 9.29 3169 91078858 XP_972061.1 1822 1.1e-200 PREDICTED: putative serine protease K12H4.7 [Tribolium castaneum] 642916112 XM_966968.2 67 8.1647e-24 PREDICTED: Tribolium castaneum putative serine protease K12H4.7 (LOC660762), mRNA -- -- -- -- P90893 781 2.3e-81 Putative serine protease F56F10.1 OS=Caenorhabditis elegans GN=F56F10.1 PE=1 SV=2 PF05577//PF02080//PF09138 Serine carboxypeptidase S28//TrkA-C domain//Urm1 (Ubiquitin related modifier) GO:0006812//GO:0034227//GO:0006508//GO:0006813 cation transport//tRNA thio-modification//proteolysis//potassium ion transport GO:0008324//GO:0008236 cation transmembrane transporter activity//serine-type peptidase activity GO:0005737 cytoplasm KOG2182 Hydrolytic enzymes of the alpha/beta hydrolase fold Cluster-8309.53134 BF_2 139.77 2.07 3108 91086935 XP_972534.1 2270 1.2e-252 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270010493|gb|EFA06941.1| hypothetical protein TcasGA2_TC009892 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1252 5.5e-136 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF05209//PF03193//PF02724//PF00664//PF01926//PF13304//PF00437 ABC transporter//Septum formation inhibitor MinC, N-terminal domain//Protein of unknown function, DUF258//CDC45-like protein//ABC transporter transmembrane region//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//Type II/IV secretion system protein GO:0009987//GO:0055085//GO:0051302//GO:0006270//GO:0006810 cellular process//transmembrane transport//regulation of cell division//DNA replication initiation//transport GO:0000166//GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 nucleotide binding//GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.53135 BF_2 60.77 0.93 3017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53136 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53138 BF_2 2.00 0.56 435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53140 BF_2 97.03 1.07 4093 817061123 XP_012252151.1 255 7.2e-19 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53142 BF_2 27.00 1.00 1413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53143 BF_2 62.28 0.87 3267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53144 BF_2 134.48 4.12 1653 546673009 ERL84695.1 319 1.1e-26 hypothetical protein D910_02121 [Dendroctonus ponderosae] -- -- -- -- -- K02435 gatC, GATC aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K02435 C3XVM1 244 2.2e-19 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Branchiostoma floridae GN=BRAFLDRAFT_270748 PE=3 SV=1 PF02686 Glu-tRNAGln amidotransferase C subunit GO:0006450 regulation of translational fidelity -- -- -- -- -- -- Cluster-8309.53145 BF_2 584.88 14.08 2025 642919000 XP_974493.2 1159 5.3e-124 PREDICTED: 1,5-anhydro-D-fructose reductase [Tribolium castaneum] -- -- -- -- -- K00011 E1.1.1.21, AKR1 aldehyde reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00011 P45376 775 7.4e-81 Aldose reductase OS=Mus musculus GN=Akr1b1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1577 Aldo/keto reductase family proteins Cluster-8309.53150 BF_2 630.00 14.55 2098 91084915 XP_970253.1 1365 7.1e-148 PREDICTED: juvenile hormone esterase [Tribolium castaneum]>gi|270008560|gb|EFA05008.1| hypothetical protein TcasGA2_TC015089 [Tribolium castaneum] -- -- -- -- -- K07378 NLGN neuroligin http://www.genome.jp/dbget-bin/www_bget?ko:K07378 P35501 602 8.8e-61 Esterase E4 OS=Myzus persicae PE=1 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53154 BF_2 12.64 0.49 1356 642933162 XP_974056.2 742 8.0e-76 PREDICTED: ubiquitin carboxyl-terminal hydrolase nonstop isoform X2 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q9VVR1 545 2.3e-54 Ubiquitin carboxyl-terminal hydrolase nonstop OS=Drosophila melanogaster GN=not PE=1 SV=3 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0036459//GO:0070140//GO:0032183 ubiquitinyl hydrolase activity//SUMO-specific isopeptidase activity//SUMO binding -- -- -- -- Cluster-8309.53155 BF_2 18.54 0.62 1545 642933164 XP_008197282.1 469 4.1e-44 PREDICTED: ubiquitin carboxyl-terminal hydrolase 22 isoform X3 [Tribolium castaneum] -- -- -- -- -- K11366 USP22_27_51, UBP8 ubiquitin carboxyl-terminal hydrolase 22/27/51 http://www.genome.jp/dbget-bin/www_bget?ko:K11366 Q9VVR1 313 2.1e-27 Ubiquitin carboxyl-terminal hydrolase nonstop OS=Drosophila melanogaster GN=not PE=1 SV=3 PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- KOG1867 Ubiquitin-specific protease Cluster-8309.53159 BF_2 89.24 0.46 8453 589968018 XP_006996507.1 370 6.9e-32 PREDICTED: zinc finger protein 431-like [Peromyscus maniculatus bairdii] -- -- -- -- -- -- -- -- -- Q9UJN7 345 2.2e-30 Zinc finger protein 391 OS=Homo sapiens GN=ZNF391 PE=2 SV=2 PF00508//PF00096//PF13465//PF09606//PF08452//PF02724//PF13912 E2 (early) protein, N terminal//Zinc finger, C2H2 type//Zinc-finger double domain//ARC105 or Med15 subunit of Mediator complex non-fungal//DNA polymerase family B exonuclease domain, N-terminal//CDC45-like protein//C2H2-type zinc finger GO:0006260//GO:0006357//GO:0006355//GO:0006270//GO:0016032//GO:0006275 DNA replication//regulation of transcription from RNA polymerase II promoter//regulation of transcription, DNA-templated//DNA replication initiation//viral process//regulation of DNA replication GO:0046872//GO:0003887//GO:0001104 metal ion binding//DNA-directed DNA polymerase activity//RNA polymerase II transcription cofactor activity GO:0042575//GO:0016592 DNA polymerase complex//mediator complex -- -- Cluster-8309.53161 BF_2 3.00 0.62 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53164 BF_2 31.00 1.00 1581 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53168 BF_2 1.11 0.42 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53174 BF_2 19.71 0.63 1587 642935122 XP_008197897.1 2108 3.8e-234 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 641668078 XM_008186100.1 34 8.94555e-06 PREDICTED: Acyrthosiphon pisum uncharacterized LOC100166039 (LOC100166039), mRNA -- -- -- -- P21783 262 1.8e-21 Neurogenic locus notch homolog protein 1 OS=Xenopus laevis GN=notch1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53175 BF_2 8.00 0.81 700 270013391 EFA09839.1 1069 5.0e-114 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 662193239 XM_008471296.1 76 1.72446e-29 PREDICTED: Diaphorina citri neurogenic locus notch homolog protein 3-like (LOC103506873), partial mRNA -- -- -- -- P97677 162 3.1e-10 Delta-like protein 1 OS=Rattus norvegicus GN=Dll1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53176 BF_2 515.48 3.31 6799 642938232 XP_008190834.1 199 3.7e-12 PREDICTED: salivary glue protein Sgs-3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13414//PF00802 TPR repeat//Pneumovirus attachment glycoprotein G -- -- GO:0005515 protein binding GO:0055036 virion membrane -- -- Cluster-8309.53179 BF_2 38.80 0.62 2885 642927089 XP_008195133.1 2938 0.0e+00 PREDICTED: rhophilin-2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TNR1 1241 9.7e-135 Rhophilin-2 OS=Danio rerio GN=rhpn2 PE=2 SV=1 PF00595//PF02185//PF13180 PDZ domain (Also known as DHR or GLGF)//Hr1 repeat//PDZ domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2220 Predicted signal transduction protein Cluster-8309.53180 BF_2 113.00 0.53 9185 270006423 EFA02871.1 12307 0.0e+00 cadherin-like protein [Tribolium castaneum] 642919273 XM_965991.3 790 0 PREDICTED: Tribolium castaneum cadherin-related tumor suppressor (LOC659713), mRNA K16669 FAT4 protocadherin Fat 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16669 P33450 8565 0.0e+00 Cadherin-related tumor suppressor OS=Drosophila melanogaster GN=ft PE=1 SV=3 PF00008//PF00028 EGF-like domain//Cadherin domain GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0016020 membrane -- -- Cluster-8309.53184 BF_2 69.46 0.55 5611 478250833 ENN71323.1 1194 1.3e-127 hypothetical protein YQE_11983, partial [Dendroctonus ponderosae]>gi|478259213|gb|ENN79116.1| hypothetical protein YQE_04427, partial [Dendroctonus ponderosae] 642918718 XM_008193332.1 144 2.28119e-66 PREDICTED: Tribolium castaneum zinc finger protein jing homolog (LOC658276), transcript variant X2, mRNA K17452 AEBP2 zinc finger protein AEBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K17452 Q17PR1 641 7.0e-65 Zinc finger protein jing homolog OS=Aedes aegypti GN=AAEL000263 PE=3 SV=1 PF16622//PF05399//PF13465//PF00096 zinc-finger C2H2-type//Ectropic viral integration site 2A protein (EVI2A)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.53185 BF_2 583.21 4.21 6080 189242026 XP_968092.2 2096 3.6e-232 PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938706|ref|XP_008196798.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938708|ref|XP_008196803.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938710|ref|XP_008196809.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938712|ref|XP_008196813.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|642938715|ref|XP_008196822.1| PREDICTED: uncharacterized protein LOC656470 [Tribolium castaneum]>gi|270015800|gb|EFA12248.1| hypothetical protein TcasGA2_TC016108 [Tribolium castaneum] 675175042 XM_008898158.1 35 9.68292e-06 Phytophthora parasitica INRA-310 hypothetical protein mRNA -- -- -- -- Q96NB2 1019 1.1e-108 Sideroflexin-2 OS=Homo sapiens GN=SFXN2 PE=1 SV=2 PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.53186 BF_2 94.37 0.61 6795 189242024 XP_967940.2 1531 1.3e-166 PREDICTED: sideroflexin-2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96NB2 1019 1.3e-108 Sideroflexin-2 OS=Homo sapiens GN=SFXN2 PE=1 SV=2 PF03820 Tricarboxylate carrier GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016020 membrane KOG3767 Sideroflexin Cluster-8309.53187 BF_2 197.71 1.74 5046 642924636 XP_008194372.1 1783 5.8e-196 PREDICTED: uncharacterized protein LOC103313276 [Tribolium castaneum]>gi|270007969|gb|EFA04417.1| hypothetical protein TcasGA2_TC014717 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09111//PF00400//PF08082//PF03854 SLIDE//WD domain, G-beta repeat//PRO8NT (NUC069), PrP8 N-terminal domain//P-11 zinc finger GO:0000398//GO:0006338 mRNA splicing, via spliceosome//chromatin remodeling GO:0016818//GO:0003676//GO:0008270//GO:0005515//GO:0005524//GO:0003723 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//zinc ion binding//protein binding//ATP binding//RNA binding GO:0005634 nucleus -- -- Cluster-8309.53188 BF_2 1462.84 255.04 527 546674493 ERL85858.1 166 1.9e-09 hypothetical protein D910_03273 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53189 BF_2 2.00 2.74 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53195 BF_2 10.00 3.09 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53200 BF_2 15.86 0.49 1644 826407464 XP_012543043.1 157 6.7e-08 PREDICTED: zinc finger protein 845-like [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- P0CG31 147 4.0e-08 Putative zinc finger protein 286B OS=Homo sapiens GN=ZNF286B PE=5 SV=1 PF00096//PF02892//PF05191 Zinc finger, C2H2 type//BED zinc finger//Adenylate kinase, active site lid GO:0046034//GO:0006144 ATP metabolic process//purine nucleobase metabolic process GO:0003677//GO:0046872//GO:0004017 DNA binding//metal ion binding//adenylate kinase activity -- -- -- -- Cluster-8309.53201 BF_2 91.44 2.40 1880 546681837 ERL91852.1 932 1.0e-97 hypothetical protein D910_09177 [Dendroctonus ponderosae] -- -- -- -- -- K15107 SLC25A18_22, GC solute carrier family 25 (mitochondrial glutamate transporter), member 18/22 http://www.genome.jp/dbget-bin/www_bget?ko:K15107 Q9H936 575 1.1e-57 Mitochondrial glutamate carrier 1 OS=Homo sapiens GN=SLC25A22 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0751 Mitochondrial aspartate/glutamate carrier protein Aralar/Citrin (contains EF-hand Ca2+-binding domains) Cluster-8309.53205 BF_2 72.30 2.26 1626 728417366 AIY68341.1 1258 1.4e-135 putative pheromone esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 669 1.2e-68 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53206 BF_2 144.70 3.88 1847 728417366 AIY68341.1 1778 8.1e-196 putative pheromone esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 787 2.7e-82 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859 Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0008152//GO:0006508 metabolic process//proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53207 BF_2 189.00 2.14 3989 390362249 XP_001190749.2 1023 6.2e-108 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 735 6.3e-76 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606//PF05349 Ankyrin repeat//Ankyrin repeat//GATA-type transcription activator, N-terminal GO:0045893 positive regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0003677 protein binding//zinc ion binding//DNA binding GO:0005634 nucleus KOG4177 Ankyrin Cluster-8309.53209 BF_2 689.00 110.47 548 835482914 AKM70276.1 175 1.8e-10 trypsin inhibitor-like cysteine-rich domain, partial [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53211 BF_2 49.11 1.84 1402 749774888 XP_011142643.1 213 1.8e-14 PREDICTED: uncharacterized protein LOC105185097 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53213 BF_2 15.35 0.86 1036 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53215 BF_2 10.00 1.32 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53216 BF_2 15.14 0.70 1189 795017626 XP_011858919.1 264 1.9e-20 PREDICTED: uncharacterized protein LOC105556435, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53217 BF_2 13.29 0.35 1865 270297198 NP_001161920.1 184 5.6e-11 peritrophic matrix protein 2-B precursor [Tribolium castaneum]>gi|268309034|gb|ACY95483.1| peritrophic matrix protein 2-B [Tribolium castaneum]>gi|270003976|gb|EFA00424.1| hypothetical protein TcasGA2_TC003275 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53218 BF_2 34.24 0.54 2945 642912584 XP_008200920.1 340 7.2e-29 PREDICTED: high affinity copper uptake protein 1 isoform X1 [Tribolium castaneum]>gi|642912586|ref|XP_008200921.1| PREDICTED: high affinity copper uptake protein 1 isoform X1 [Tribolium castaneum]>gi|642912588|ref|XP_008200922.1| PREDICTED: high affinity copper uptake protein 1 isoform X1 [Tribolium castaneum]>gi|642912590|ref|XP_008200923.1| PREDICTED: high affinity copper uptake protein 1 isoform X1 [Tribolium castaneum]>gi|642912592|ref|XP_008200925.1| PREDICTED: high affinity copper uptake protein 1 isoform X1 [Tribolium castaneum]>gi|642912594|ref|XP_008200926.1| PREDICTED: high affinity copper uptake protein 1 isoform X1 [Tribolium castaneum]>gi|270002403|gb|EEZ98850.1| hypothetical protein TcasGA2_TC004460 [Tribolium castaneum] 194896366 XM_001978429.1 74 9.73745e-28 Drosophila erecta GG19602 (Dere\GG19602), mRNA K14686 SLC31A1, CTR1 solute carrier family 31 (copper transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14686 O15431 262 3.3e-21 High affinity copper uptake protein 1 OS=Homo sapiens GN=SLC31A1 PE=1 SV=1 PF04145//PF06305 Ctr copper transporter family//Protein of unknown function (DUF1049) GO:0035434//GO:0006825 copper ion transmembrane transport//copper ion transport GO:0005375 copper ion transmembrane transporter activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane KOG3386 Copper transporter Cluster-8309.53220 BF_2 124.00 3.21 1901 478252327 ENN72753.1 442 6.9e-41 hypothetical protein YQE_10558, partial [Dendroctonus ponderosae] -- -- -- -- -- K00861 RFK, FMN1 riboflavin kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00861 Q8CFV9 418 1.7e-39 Riboflavin kinase OS=Mus musculus GN=Rfk PE=1 SV=2 PF01687 Riboflavin kinase GO:0009231 riboflavin biosynthetic process GO:0008531 riboflavin kinase activity -- -- KOG3110 Riboflavin kinase Cluster-8309.53221 BF_2 24.10 0.47 2421 91092636 XP_968782.1 1194 5.5e-128 PREDICTED: neurogenic protein big brain [Tribolium castaneum]>gi|270014847|gb|EFA11295.1| hypothetical protein TcasGA2_TC010832 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 P23645 1046 3.3e-112 Neurogenic protein big brain OS=Drosophila melanogaster GN=bib PE=1 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.53223 BF_2 5.00 0.45 756 24643074 NP_573311.1 149 2.6e-07 CG15040 [Drosophila melanogaster]>gi|7293488|gb|AAF48863.1| CG15040 [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- Q55FT4 131 1.3e-06 Probable serine/threonine-protein kinase tsuA OS=Dictyostelium discoideum GN=tsuA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53225 BF_2 248.00 2.36 4676 270014284 EFA10732.1 3928 0.0e+00 teashirt-like protein [Tribolium castaneum] 86515361 NM_001039415.1 731 0 Tribolium castaneum teashirt-like protein (Tiotsh), mRNA >gnl|BL_ORD_ID|994588 Tribolium castaneum clone pctsh10 teashirt-like protein mRNA, complete cds -- -- -- -- Q9U3V5 1208 1.1e-130 Protein tiptop OS=Drosophila melanogaster GN=tio PE=2 SV=2 PF01277//PF11045//PF00096//PF13912//PF06467 Oleosin//Putative inner membrane protein of Enterobacteriaceae//Zinc finger, C2H2 type//C2H2-type zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0012511//GO:0016021 monolayer-surrounded lipid storage body//integral component of membrane -- -- Cluster-8309.53227 BF_2 46.46 0.40 5201 642912105 XP_008200807.1 181 3.5e-10 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53234 BF_2 323.96 2.79 5147 617299376 XP_007570232.1 969 1.5e-101 PREDICTED: zinc finger protein 236 [Poecilia formosa] -- -- -- -- -- -- -- -- -- P10076 663 1.8e-67 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF00096//PF13465 C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.53238 BF_2 457.94 15.48 1525 91093505 XP_969151.1 1925 6.0e-213 PREDICTED: NADP-dependent malic enzyme [Tribolium castaneum]>gi|270002678|gb|EEZ99125.1| hypothetical protein TcasGA2_TC005232 [Tribolium castaneum] 194765020 XM_001964590.1 291 1.17055e-148 Drosophila ananassae GF23280 (Dana\GF23280), mRNA K00029 E1.1.1.40, maeB malate dehydrogenase (oxaloacetate-decarboxylating)(NADP+) http://www.genome.jp/dbget-bin/www_bget?ko:K00029 P28227 1320 3.5e-144 NADP-dependent malic enzyme OS=Anas platyrhynchos GN=ME1 PE=1 SV=1 PF00390//PF03949 Malic enzyme, N-terminal domain//Malic enzyme, NAD binding domain GO:0055114//GO:0006108//GO:0006099//GO:0015976//GO:0006090 oxidation-reduction process//malate metabolic process//tricarboxylic acid cycle//carbon utilization//pyruvate metabolic process GO:0046872//GO:0004471//GO:0051287 metal ion binding//malate dehydrogenase (decarboxylating) (NAD+) activity//NAD binding -- -- KOG1257 NADP+-dependent malic enzyme Cluster-8309.53239 BF_2 162.78 3.99 1994 642914834 XP_008194983.1 1294 1.2e-139 PREDICTED: inhibitor of growth protein 3 isoform X1 [Tribolium castaneum] 795091176 XM_012024084.1 52 1.11328e-15 PREDICTED: Vollenhovia emeryi inhibitor of growth protein 3 (LOC105568417), transcript variant X2, mRNA K11319 ING3 inhibitor of growth protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11319 Q9NXR8 680 7.5e-70 Inhibitor of growth protein 3 OS=Homo sapiens GN=ING3 PE=1 SV=2 PF00160//PF10280//PF12090//PF03153 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD//Mediator complex protein//Spt20 family//Transcription factor IIA, alpha/beta subunit GO:0006457//GO:0006357//GO:0006367//GO:0000413 protein folding//regulation of transcription from RNA polymerase II promoter//transcription initiation from RNA polymerase II promoter//protein peptidyl-prolyl isomerization GO:0001104//GO:0003755//GO:0003712 RNA polymerase II transcription cofactor activity//peptidyl-prolyl cis-trans isomerase activity//transcription cofactor activity GO:0016592//GO:0005667//GO:0000124//GO:0005672 mediator complex//transcription factor complex//SAGA complex//transcription factor TFIIA complex KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.53240 BF_2 1.00 1.56 296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02209 Villin headpiece domain GO:0007010 cytoskeleton organization GO:0003779 actin binding -- -- -- -- Cluster-8309.53241 BF_2 197.76 5.67 1745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53245 BF_2 58.13 1.14 2427 189235679 XP_971393.2 170 3.1e-09 PREDICTED: sperm surface protein Sp17 [Tribolium castaneum]>gi|270004446|gb|EFA00894.1| hypothetical protein TcasGA2_TC003798 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00612 IQ calmodulin-binding motif GO:0040008 regulation of growth GO:0005515 protein binding -- -- -- -- Cluster-8309.53246 BF_2 26.06 3.87 569 270006955 EFA03403.1 369 6.0e-33 hypothetical protein TcasGA2_TC013390 [Tribolium castaneum] -- -- -- -- -- K13645 PLOD2 procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13645 O00469 249 2.0e-20 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 OS=Homo sapiens GN=PLOD2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1971 Lysyl hydroxylase Cluster-8309.53249 BF_2 107.37 1.42 3443 642933889 XP_008197555.1 1452 9.6e-158 PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum]>gi|642933891|ref|XP_008197556.1| PREDICTED: uncharacterized protein LOC659539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B3KS81 141 4.1e-07 Serine/arginine repetitive matrix protein 5 OS=Homo sapiens GN=SRRM5 PE=1 SV=3 PF00437//PF00448//PF02421//PF00493//PF04548//PF00910//PF03266//PF03193//PF00005//PF00004//PF08477//PF00735//PF07728//PF01926//PF00158//PF03613//PF02367 Type II/IV secretion system protein//SRP54-type protein, GTPase domain//Ferrous iron transport protein B//MCM2/3/5 family//AIG1 family//RNA helicase//NTPase//Protein of unknown function, DUF258//ABC transporter//ATPase family associated with various cellular activities (AAA)//Ras of Complex, Roc, domain of DAPkinase//Septin//AAA domain (dynein-related subfamily)//50S ribosome-binding GTPase//Sigma-54 interaction domain//PTS system mannose/fructose/sorbose family IID component//Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0006810//GO:0006614//GO:0015684//GO:0009401//GO:0006260//GO:0006355//GO:0007264//GO:0002949 transport//SRP-dependent cotranslational protein targeting to membrane//ferrous iron transport//phosphoenolpyruvate-dependent sugar phosphotransferase system//DNA replication//regulation of transcription, DNA-templated//small GTPase mediated signal transduction//tRNA threonylcarbamoyladenosine modification GO:0008134//GO:0003924//GO:0098519//GO:0005524//GO:0016887//GO:0003677//GO:0015093//GO:0003723//GO:0003724//GO:0005525 transcription factor binding//GTPase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//ATPase activity//DNA binding//ferrous iron transmembrane transporter activity//RNA binding//RNA helicase activity//GTP binding GO:0016021//GO:0005667 integral component of membrane//transcription factor complex -- -- Cluster-8309.53254 BF_2 311.53 8.56 1810 642911837 XP_008200767.1 194 3.8e-12 PREDICTED: endophilin-A isoform X4 [Tribolium castaneum] -- -- -- -- -- K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I1A6 171 7.2e-11 Endophilin-A OS=Drosophila willistoni GN=endoA PE=3 SV=1 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.53259 BF_2 200.00 2.63 3467 546680054 ERL90409.1 2899 0.0e+00 hypothetical protein D910_07758, partial [Dendroctonus ponderosae] -- -- -- -- -- K13146 INTS9 integrator complex subunit 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13146 Q8K114 1741 1.2e-192 Integrator complex subunit 9 OS=Mus musculus GN=Ints9 PE=2 SV=1 PF00076//PF01896//PF05625 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Eukaryotic and archaeal DNA primase small subunit//PAXNEB protein GO:0006269//GO:0006351 DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896//GO:0003676 DNA primase activity//nucleic acid binding GO:0005657//GO:0005730//GO:0033588 replication fork//nucleolus//Elongator holoenzyme complex KOG1138 Predicted cleavage and polyadenylation specificity factor (CPSF subunit) Cluster-8309.53260 BF_2 7.78 0.33 1268 34099638 AAQ57129.1 871 8.3e-91 endonuclease and reverse transcriptase-like protein [Bombyx mori] 347439535 JN415099.1 335 3.36279e-173 Scylla paramamosain clone QX04 microsatellite sequence -- -- -- -- Q95SX7 344 4.4e-31 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF09004 Domain of unknown function (DUF1891) GO:0055114 oxidation-reduction process GO:0008168//GO:0016706 methyltransferase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors -- -- -- -- Cluster-8309.53261 BF_2 342.37 4.11 3774 642918805 XP_008191593.1 3414 0.0e+00 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 2080 6.5e-232 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0208 Cation transport ATPase Cluster-8309.53263 BF_2 60.31 0.78 3507 642918805 XP_008191593.1 2275 3.6e-253 PREDICTED: probable cation-transporting ATPase 13A3 [Tribolium castaneum] -- -- -- -- -- K14951 ATP13A3_4_5 cation-transporting ATPase 13A3/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K14951 Q9H7F0 1426 4.1e-156 Probable cation-transporting ATPase 13A3 OS=Homo sapiens GN=ATP13A3 PE=1 SV=4 PF00122 E1-E2 ATPase -- -- GO:0000166//GO:0046872 nucleotide binding//metal ion binding -- -- KOG0208 Cation transport ATPase Cluster-8309.53264 BF_2 5.00 1.57 420 635070413 XP_008004027.1 368 5.8e-33 PREDICTED: hamartin isoform X3 [Chlorocebus sabaeus] 254039583 NG_012386.1 420 0 Homo sapiens tuberous sclerosis 1 (TSC1), RefSeqGene (LRG_486) on chromosome 9 K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q92574 320 8.7e-29 Hamartin OS=Homo sapiens GN=TSC1 PE=1 SV=2 PF15836 SSTK-interacting protein, TSSK6-activating co-chaperone protein -- -- GO:0051087 chaperone binding -- -- -- -- Cluster-8309.53266 BF_2 984.00 57.34 1005 642928984 XP_008195645.1 736 3.0e-75 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q02401 511 1.5e-50 Lactase-phlorizin hydrolase OS=Rattus norvegicus GN=Lct PE=2 SV=2 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0016787 hydrolase activity, hydrolyzing O-glycosyl compounds//hydrolase activity -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.53273 BF_2 31.37 0.33 4212 270008864 EFA05312.1 1399 1.6e-151 hypothetical protein TcasGA2_TC015470 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04146 688 1.9e-70 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF13683//PF00098//PF00665//PF02932 Integrase core domain//Zinc knuckle//Integrase core domain//Neurotransmitter-gated ion-channel transmembrane region GO:0015074//GO:0006811 DNA integration//ion transport GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0016020 membrane -- -- Cluster-8309.53284 BF_2 5.00 1.93 394 767943395 XP_011534351.1 300 4.2e-25 PREDICTED: proto-oncogene tyrosine-protein kinase ROS isoform X1 [Homo sapiens] 584458492 NG_033929.1 391 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 300 1.7e-26 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53285 BF_2 14.23 0.94 920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53286 BF_2 3.00 0.41 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53289 BF_2 319.77 4.58 3209 270003759 EFA00207.1 1160 6.4e-124 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 3.82004e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.0e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0005515//GO:0003723 protein binding//RNA binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.53292 BF_2 54.38 0.44 5400 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53293 BF_2 13.00 1.39 679 91088247 XP_974080.1 211 1.5e-14 PREDICTED: POC1 centriolar protein homolog B [Tribolium castaneum]>gi|270011818|gb|EFA08266.1| hypothetical protein TcasGA2_TC005896 [Tribolium castaneum] -- -- -- -- -- K16482 POC1 centriolar protein POC1 http://www.genome.jp/dbget-bin/www_bget?ko:K16482 Q28I85 198 2.0e-14 POC1 centriolar protein homolog A OS=Xenopus tropicalis GN=poc1a PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53296 BF_2 97.13 5.22 1066 674304006 AIL23534.1 424 4.7e-39 glutathione S-transferase epsilon [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P46430 286 2.0e-24 Glutathione S-transferase 1 OS=Manduca sexta GN=GST1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53298 BF_2 20.93 0.66 1609 642912303 XP_008200641.1 626 2.7e-62 PREDICTED: protein couch potato isoform X3 [Tribolium castaneum] 642912302 XM_008202419.1 206 2.20519e-101 PREDICTED: Tribolium castaneum protein couch potato (LOC657238), transcript variant X3, mRNA -- -- -- -- Q01617 332 1.4e-29 Protein couch potato OS=Drosophila melanogaster GN=cpo PE=2 SV=3 PF00076//PF17051 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Cytochrome C oxidase assembly factor 2 GO:0033617 mitochondrial respiratory chain complex IV assembly GO:0003676 nucleic acid binding -- -- KOG1457 RNA binding protein (contains RRM repeats) Cluster-8309.53299 BF_2 8.00 0.49 966 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53303 BF_2 4.00 2.97 337 478255063 ENN75293.1 144 4.3e-07 hypothetical protein YQE_08070, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53304 BF_2 83.38 1.04 3625 602166190 AHN85842.1 1751 2.1e-192 octopamine beta receptor 2 [Nicrophorus vespilloides] -- -- -- -- -- K04160 HTR4 5-hydroxytryptamine receptor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04160 Q4LBB9 1334 2.0e-145 Octopamine receptor beta-2R OS=Drosophila melanogaster GN=Octbeta2R PE=2 SV=2 PF00001//PF01769//PF01717 7 transmembrane receptor (rhodopsin family)//Divalent cation transporter//Cobalamin-independent synthase, Catalytic domain GO:0009086//GO:0007186//GO:0006812 methionine biosynthetic process//G-protein coupled receptor signaling pathway//cation transport GO:0004930//GO:0008324//GO:0008270//GO:0003871 G-protein coupled receptor activity//cation transmembrane transporter activity//zinc ion binding//5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity GO:0016021 integral component of membrane -- -- Cluster-8309.53305 BF_2 109.02 1.35 3667 642918209 XP_008191412.1 1177 7.9e-126 PREDICTED: methyltransferase-like protein 9 isoform X1 [Tribolium castaneum]>gi|270004533|gb|EFA00981.1| hypothetical protein TcasGA2_TC003894 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EPL4 639 7.9e-65 Methyltransferase-like protein 9 OS=Mus musculus GN=Mettl9 PE=2 SV=1 PF08241//PF04218//PF01234//PF05958 Methyltransferase domain//CENP-B N-terminal DNA-binding domain//NNMT/PNMT/TEMT family//tRNA (Uracil-5-)-methyltransferase GO:0006396//GO:0008152//GO:0009451 RNA processing//metabolic process//RNA modification GO:0008173//GO:0008168//GO:0003677 RNA methyltransferase activity//methyltransferase activity//DNA binding -- -- KOG3987 Uncharacterized conserved protein DREV/CGI-81 Cluster-8309.53308 BF_2 13.00 0.74 1018 662215753 XP_008481775.1 594 8.8e-59 PREDICTED: uncharacterized protein LOC103518486 [Diaphorina citri] -- -- -- -- -- -- -- -- -- P04323 455 4.7e-44 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.53311 BF_2 91.29 0.66 6108 270004778 EFA01226.1 1478 1.6e-160 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 1060 2.0e-113 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF16867//PF00665 Integrase core domain//Dimethlysulfonioproprionate lyase//Integrase core domain GO:0015074 DNA integration GO:0047869 dimethylpropiothetin dethiomethylase activity -- -- -- -- Cluster-8309.53316 BF_2 8.00 3.09 394 194318490 ACF47633.1 530 8.9e-52 soluble FGFR1 variant 2 [Homo sapiens] 188219627 NG_007729.1 394 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P21804 256 2.2e-21 Fibroblast growth factor receptor 1 OS=Gallus gallus GN=FGFR1 PE=2 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53323 BF_2 37.00 0.92 1969 270009808 EFA06256.1 670 2.6e-67 hypothetical protein TcasGA2_TC009115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04146 142 1.8e-07 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF00098 Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.53324 BF_2 238.67 3.99 2787 546674612 ERL85961.1 989 3.8e-104 hypothetical protein D910_03376 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SPP0 594 9.9e-60 Clavesin-2 OS=Danio rerio GN=clvs2 PE=2 SV=1 PF08675 RNA binding domain GO:0051252//GO:0006402 regulation of RNA metabolic process//mRNA catabolic process GO:0046872//GO:0004535//GO:0003723 metal ion binding//poly(A)-specific ribonuclease activity//RNA binding GO:0005737//GO:0005634 cytoplasm//nucleus -- -- Cluster-8309.53325 BF_2 456.99 34.71 838 642928984 XP_008195645.1 904 8.1e-95 PREDICTED: myrosinase 1 [Tribolium castaneum]>gi|270009720|gb|EFA06168.1| hypothetical protein TcasGA2_TC009015 [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P09849 615 1.1e-62 Lactase-phlorizin hydrolase OS=Oryctolagus cuniculus GN=LCT PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0008152//GO:0005975 metabolic process//carbohydrate metabolic process GO:0016798//GO:0004553 hydrolase activity, acting on glycosyl bonds//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.53327 BF_2 421.02 15.64 1413 748995278 AJE75661.1 853 1.1e-88 putative glycosyl hydrolase [Chrysomela lapponica] 636630775 KJ576835.1 42 2.83654e-10 Periplaneta americana clone PA_BetaGlu_1701 beta-glucosidase mRNA, complete cds K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 656 3.2e-67 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00150//PF00232 Cellulase (glycosyl hydrolase family 5)//Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.53328 BF_2 97.15 0.68 6306 642913543 XP_971895.2 672 4.9e-67 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 9.5e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF13639//PF16685//PF02736//PF06003//PF01363//PF01155//PF06506//PF00097//PF12678//PF14634//PF00643 Ring finger domain//zinc RING finger of MSL2//Myosin N-terminal SH3-like domain//Survival motor neuron protein (SMN)//FYVE zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Propionate catabolism activator//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain//B-box zinc finger GO:0000160//GO:0006464//GO:0006397 phosphorelay signal transduction system//cellular protein modification process//mRNA processing GO:0000156//GO:0008270//GO:0005524//GO:0046872//GO:0003774//GO:0005515//GO:0061630//GO:0016151//GO:0003677//GO:0003723 phosphorelay response regulator activity//zinc ion binding//ATP binding//metal ion binding//motor activity//protein binding//ubiquitin protein ligase activity//nickel cation binding//DNA binding//RNA binding GO:0005737//GO:0005622//GO:0016459//GO:0005634 cytoplasm//intracellular//myosin complex//nucleus -- -- Cluster-8309.53329 BF_2 166.79 1.56 4763 478251175 ENN71651.1 1844 4.6e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.53330 BF_2 136.58 1.02 5903 642932649 XP_969929.2 1013 1.3e-106 PREDICTED: mitochondrial uncoupling protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15112 SLC25A27, UCP4 solute carrier family 25 (mitochondrial uncoupling protein), member 27 http://www.genome.jp/dbget-bin/www_bget?ko:K15112 O95847 705 2.8e-72 Mitochondrial uncoupling protein 4 OS=Homo sapiens GN=SLC25A27 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0753 Mitochondrial fatty acid anion carrier protein/Uncoupling protein Cluster-8309.53332 BF_2 188.54 4.26 2139 642926395 XP_970524.2 955 2.5e-100 PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926397|ref|XP_008191945.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926399|ref|XP_008191946.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum] -- -- -- -- -- K07899 RAB9A, RAB9 Ras-related protein Rab-9A http://www.genome.jp/dbget-bin/www_bget?ko:K07899 Q99P75 613 4.7e-62 Ras-related protein Rab-9A OS=Rattus norvegicus GN=Rab9a PE=1 SV=2 PF08477//PF00735//PF01926//PF00025//PF03193//PF01637//PF04670//PF00071 Ras of Complex, Roc, domain of DAPkinase//Septin//50S ribosome-binding GTPase//ADP-ribosylation factor family//Protein of unknown function, DUF258//Archaeal ATPase//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005525//GO:0005524//GO:0003924 GTP binding//ATP binding//GTPase activity -- -- KOG0394 Ras-related GTPase Cluster-8309.53333 BF_2 944.00 66.95 877 86279289 ABC88740.1 526 5.8e-51 putative serine proteinase [Tenebrio molitor] -- -- -- -- -- K01353 GZMB granzyme B http://www.genome.jp/dbget-bin/www_bget?ko:K01353 O97398 455 4.1e-44 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.53334 BF_2 52.00 0.69 3437 546687691 ERL96264.1 1510 1.8e-164 hypothetical protein D910_01676 [Dendroctonus ponderosae] -- -- -- -- -- K02603 ORC1 origin recognition complex subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02603 O16810 1161 2.2e-125 Origin recognition complex subunit 1 OS=Drosophila melanogaster GN=Orc1 PE=1 SV=2 PF05790//PF00004 Immunoglobulin C2-set domain//ATPase family associated with various cellular activities (AAA) GO:0007155 cell adhesion GO:0005524 ATP binding GO:0016021 integral component of membrane KOG1514 Origin recognition complex, subunit 1, and related proteins Cluster-8309.53336 BF_2 96.92 0.56 7531 167234451 NP_001107840.1 1588 3.6e-173 Dicer-2 [Tribolium castaneum]>gi|642913971|ref|XP_008201496.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|642913973|ref|XP_008201497.1| PREDICTED: dicer-2 isoform X1 [Tribolium castaneum]>gi|270002830|gb|EEZ99277.1| hypothetical protein TcasGA2_TC001108 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34529 664 2.0e-67 Endoribonuclease dcr-1 OS=Caenorhabditis elegans GN=dcr-1 PE=1 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase GO:0016072//GO:0051252//GO:0034470 rRNA metabolic process//regulation of RNA metabolic process//ncRNA processing GO:0003676//GO:0016891//GO:0043167//GO:0003677//GO:0016787//GO:0005524//GO:0004386//GO:0003723 nucleic acid binding//endoribonuclease activity, producing 5'-phosphomonoesters//ion binding//DNA binding//hydrolase activity//ATP binding//helicase activity//RNA binding -- -- KOG0701 dsRNA-specific nuclease Dicer and related ribonucleases Cluster-8309.53338 BF_2 514.03 1.27 17178 642935122 XP_008197897.1 19614 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1002 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q61555 1378 7.5e-150 Fibrillin-2 OS=Mus musculus GN=Fbn2 PE=1 SV=2 PF00008//PF06553//PF07645 EGF-like domain//BNIP3//Calcium-binding EGF domain GO:0043065 positive regulation of apoptotic process GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0016021//GO:0005740 integral component of membrane//mitochondrial envelope -- -- Cluster-8309.53339 BF_2 115.60 0.80 6345 642935122 XP_008197897.1 9537 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC658528 [Tribolium castaneum] 642935121 XM_008199675.1 1051 0 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 678 4.1e-69 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.5334 BF_2 11.61 0.64 1045 642924290 XP_008194235.1 164 6.5e-09 PREDICTED: zinc finger protein 385B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53340 BF_2 236.20 0.82 12406 270013710 EFA10158.1 5372 0.0e+00 hypothetical protein TcasGA2_TC012347 [Tribolium castaneum] 642934484 XM_008199462.1 543 0 PREDICTED: Tribolium castaneum kinase D-interacting substrate of 220 kDa (LOC100141654), transcript variant X8, mRNA K12460 KIDINS220, ARMS ankyrin repeat-rich membrane spanning protein http://www.genome.jp/dbget-bin/www_bget?ko:K12460 Q7T163 2577 5.0e-289 Kinase D-interacting substrate of 220 kDa OS=Danio rerio GN=kidins220 PE=2 SV=2 PF00960//PF05510//PF00536//PF06553//PF03400//PF13606//PF00023 Neocarzinostatin family//Sarcoglycan alpha/epsilon//SAM domain (Sterile alpha motif)//BNIP3//IS1 transposase//Ankyrin repeat//Ankyrin repeat GO:0006952//GO:0006313//GO:0043065 defense response//transposition, DNA-mediated//positive regulation of apoptotic process GO:0005515//GO:0003677//GO:0004803 protein binding//DNA binding//transposase activity GO:0016021//GO:0016012//GO:0005740 integral component of membrane//sarcoglycan complex//mitochondrial envelope -- -- Cluster-8309.53342 BF_2 360.61 1.91 8180 642924482 XP_008194314.1 3740 0.0e+00 PREDICTED: protein ELYS isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5U249 903 4.3e-95 Protein ELYS OS=Xenopus laevis GN=ahctf1 PE=1 SV=1 PF05210 Sprouty protein (Spry) GO:0007275//GO:0009966 multicellular organismal development//regulation of signal transduction -- -- GO:0016020 membrane -- -- Cluster-8309.53344 BF_2 235.00 0.93 10830 642920841 XP_008192580.1 12538 0.0e+00 PREDICTED: LOW QUALITY PROTEIN: protein dachsous [Tribolium castaneum] 170031842 XM_001843741.1 41 7.98557e-09 Culex quinquefasciatus cadherin, mRNA K16507 DCHS1_2, PCDH16_23 protocadherin-16/23 http://www.genome.jp/dbget-bin/www_bget?ko:K16507 Q24292 6882 0.0e+00 Protein dachsous OS=Drosophila melanogaster GN=ds PE=1 SV=3 PF01247//PF01049//PF00028 Ribosomal protein L35Ae//Cadherin cytoplasmic region//Cadherin domain GO:0042254//GO:0006412//GO:0007156 ribosome biogenesis//translation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0005509//GO:0003735 calcium ion binding//structural constituent of ribosome GO:0005840//GO:0016020//GO:0005622 ribosome//membrane//intracellular KOG1219 Uncharacterized conserved protein, contains laminin, cadherin and EGF domains Cluster-8309.53346 BF_2 126.87 2.44 2460 642921104 XP_008192691.1 1190 1.6e-127 PREDICTED: CLK4-associating serine/arginine rich protein [Tribolium castaneum]>gi|270006186|gb|EFA02634.1| hypothetical protein TcasGA2_TC008355 [Tribolium castaneum] -- -- -- -- -- K13168 SFRS16 splicing factor, arginine/serine-rich 16 http://www.genome.jp/dbget-bin/www_bget?ko:K13168 Q8N2M8 609 1.6e-61 CLK4-associating serine/arginine rich protein OS=Homo sapiens GN=CLASRP PE=1 SV=4 PF15678//PF09726//PF05279//PF02535//PF04882 Centriole duplication and mitotic chromosome congression//Transmembrane protein//Aspartyl beta-hydroxylase N-terminal region//ZIP Zinc transporter//Peroxin-3 GO:0055085//GO:0007031//GO:0030001//GO:0090307 transmembrane transport//peroxisome organization//metal ion transport//mitotic spindle assembly GO:0046873 metal ion transmembrane transporter activity GO:0016020//GO:0005779//GO:0016021 membrane//integral component of peroxisomal membrane//integral component of membrane KOG2548 SWAP mRNA splicing regulator Cluster-8309.53349 BF_2 25.98 0.61 2076 189234531 XP_967948.2 889 1.1e-92 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 693 2.4e-71 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF00324//PF03522 Amino acid permease//Solute carrier family 12 GO:0006811//GO:0006810//GO:0055085 ion transport//transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane KOG2083 Na+/K+ symporter Cluster-8309.53350 BF_2 229.22 1.78 5674 642920242 XP_008192264.1 5773 0.0e+00 PREDICTED: uncharacterized protein CG43867 isoform X2 [Tribolium castaneum] 194768448 XM_001966288.1 67 1.46928e-23 Drosophila ananassae GF22056 (Dana\GF22056), mRNA -- -- -- -- Q9W5D0 2338 1.2e-261 Uncharacterized protein CG43867 OS=Drosophila melanogaster GN=CG43867 PE=1 SV=4 PF05864//PF00784 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//MyTH4 domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005856//GO:0005730 cytoskeleton//nucleolus KOG0248 Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains Cluster-8309.53351 BF_2 437.90 1.42 13147 642930187 XP_008196292.1 4575 0.0e+00 PREDICTED: spatacsin [Tribolium castaneum]>gi|270009457|gb|EFA05905.1| hypothetical protein TcasGA2_TC008718 [Tribolium castaneum] 195121589 XM_002005267.1 94 3.34371e-38 Drosophila mojavensis GI20407 (Dmoj\GI20407), mRNA K07832 RIT1 Ras-like without CAAX 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07832 Q3UHA3 742 3.2e-76 Spatacsin OS=Mus musculus GN=Spg11 PE=2 SV=3 PF00962//PF03193//PF02459//PF00071//PF01979//PF08477//PF08533//PF00025 Adenosine/AMP deaminase//Protein of unknown function, DUF258//Adenoviral DNA terminal protein//Ras family//Amidohydrolase family//Ras of Complex, Roc, domain of DAPkinase//Beta-galactosidase C-terminal domain//ADP-ribosylation factor family GO:0006027//GO:0006012//GO:0007264//GO:0046486//GO:0006687//GO:0006260 glycosaminoglycan catabolic process//galactose metabolic process//small GTPase mediated signal transduction//glycerolipid metabolic process//glycosphingolipid metabolic process//DNA replication GO:0019239//GO:0003924//GO:0016787//GO:0003677//GO:0004565//GO:0005525 deaminase activity//GTPase activity//hydrolase activity//DNA binding//beta-galactosidase activity//GTP binding GO:0009341 beta-galactosidase complex KOG0395 Ras-related GTPase Cluster-8309.53353 BF_2 105.59 0.34 13247 642930187 XP_008196292.1 3030 0.0e+00 PREDICTED: spatacsin [Tribolium castaneum]>gi|270009457|gb|EFA05905.1| hypothetical protein TcasGA2_TC008718 [Tribolium castaneum] 195121589 XM_002005267.1 94 3.36922e-38 Drosophila mojavensis GI20407 (Dmoj\GI20407), mRNA K07832 RIT1 Ras-like without CAAX 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07832 P70426 634 1.1e-63 GTP-binding protein Rit1 OS=Mus musculus GN=Rit1 PE=1 SV=1 PF08533//PF00025//PF01979//PF08477//PF00071//PF03193//PF00962//PF02459 Beta-galactosidase C-terminal domain//ADP-ribosylation factor family//Amidohydrolase family//Ras of Complex, Roc, domain of DAPkinase//Ras family//Protein of unknown function, DUF258//Adenosine/AMP deaminase//Adenoviral DNA terminal protein GO:0006012//GO:0006027//GO:0006260//GO:0006687//GO:0046486//GO:0007264 galactose metabolic process//glycosaminoglycan catabolic process//DNA replication//glycosphingolipid metabolic process//glycerolipid metabolic process//small GTPase mediated signal transduction GO:0003677//GO:0004565//GO:0016787//GO:0003924//GO:0019239//GO:0005525 DNA binding//beta-galactosidase activity//hydrolase activity//GTPase activity//deaminase activity//GTP binding GO:0009341 beta-galactosidase complex KOG0395 Ras-related GTPase Cluster-8309.53354 BF_2 67.73 1.15 2750 642924514 XP_008194327.1 841 5.4e-87 PREDICTED: nuclear fragile X mental retardation-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QXX8 333 1.8e-29 Nuclear fragile X mental retardation-interacting protein 1 OS=Mus musculus GN=Nufip1 PE=1 SV=1 PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.53356 BF_2 9.66 4.06 385 549438545 AGX25161.1 160 6.9e-09 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53358 BF_2 35.70 0.42 3861 549438545 AGX25161.1 2415 2.3e-269 dipeptidyl peptidase [Leptinotarsa decemlineata] -- -- -- -- -- K01278 DPP4 dipeptidyl-peptidase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K01278 B2D0J4 1472 2.1e-161 Venom dipeptidyl peptidase 4 OS=Apis mellifera PE=1 SV=1 PF01738//PF03583//PF00930//PF02129//PF00326//PF02805 Dienelactone hydrolase family//Secretory lipase//Dipeptidyl peptidase IV (DPP IV) N-terminal region//X-Pro dipeptidyl-peptidase (S15 family)//Prolyl oligopeptidase family//Metal binding domain of Ada GO:0046486//GO:0006508//GO:0016042//GO:0006355//GO:0006281 glycerolipid metabolic process//proteolysis//lipid catabolic process//regulation of transcription, DNA-templated//DNA repair GO:0008236//GO:0008270//GO:0008168//GO:0004806//GO:0016787//GO:0003677 serine-type peptidase activity//zinc ion binding//methyltransferase activity//triglyceride lipase activity//hydrolase activity//DNA binding -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.53361 BF_2 27.92 0.33 3823 189237458 XP_967667.2 522 7.3e-50 PREDICTED: solute carrier family 35 member E2-like [Tribolium castaneum] -- -- -- -- -- K15284 SLC35E2 solute carrier family 35, member E2 http://www.genome.jp/dbget-bin/www_bget?ko:K15284 Q8C811 281 2.7e-23 Solute carrier family 35 member E2 OS=Mus musculus GN=Slc35e2 PE=2 SV=1 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016021//GO:0016020 integral component of membrane//membrane KOG1441 Glucose-6-phosphate/phosphate and phosphoenolpyruvate/phosphate antiporter Cluster-8309.53362 BF_2 142.18 1.26 5013 478251160 ENN71636.1 1384 1.1e-149 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04931//PF01080//PF02724//PF04843 DNA polymerase phi//Presenilin//CDC45-like protein//Herpesvirus tegument protein, N-terminal conserved region GO:0006508//GO:0006260//GO:0006270//GO:0006351 proteolysis//DNA replication//DNA replication initiation//transcription, DNA-templated GO:0008233//GO:0003887//GO:0004190//GO:0003677 peptidase activity//DNA-directed DNA polymerase activity//aspartic-type endopeptidase activity//DNA binding GO:0042575//GO:0016021 DNA polymerase complex//integral component of membrane -- -- Cluster-8309.53363 BF_2 36.61 0.32 5125 478251160 ENN71636.1 1051 4.5e-111 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04931//PF06459 DNA polymerase phi//Ryanodine Receptor TM 4-6 GO:0006351//GO:0006816//GO:0006874//GO:0006260 transcription, DNA-templated//calcium ion transport//cellular calcium ion homeostasis//DNA replication GO:0003887//GO:0005219//GO:0003677 DNA-directed DNA polymerase activity//ryanodine-sensitive calcium-release channel activity//DNA binding GO:0042575//GO:0016021//GO:0005622 DNA polymerase complex//integral component of membrane//intracellular -- -- Cluster-8309.53366 BF_2 11.00 1.69 559 449668742 XP_004206862.1 223 5.0e-16 PREDICTED: 60S acidic ribosomal protein P1-like [Hydra vulgaris] 347660859 BT131212.1 559 0 Oryza sativa clone RRlibD01031 mRNA sequence K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P52855 261 8.1e-22 60S acidic ribosomal protein P1 OS=Zea mays GN=RPP1A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.53367 BF_2 286.27 2.38 5318 91078468 XP_967964.1 2089 2.0e-231 PREDICTED: integral membrane protein GPR180 isoform X1 [Tribolium castaneum]>gi|270003859|gb|EFA00307.1| hypothetical protein TcasGA2_TC003142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q976I0 277 1.1e-22 Peptidyl-tRNA hydrolase OS=Sulfolobus tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) GN=pth PE=3 SV=1 PF10192//PF01981//PF02891//PF05051 Rhodopsin-like GPCR transmembrane domain//Peptidyl-tRNA hydrolase PTH2//MIZ/SP-RING zinc finger//Cytochrome C oxidase copper chaperone (COX17) GO:0019236//GO:0007186//GO:0006825 response to pheromone//G-protein coupled receptor signaling pathway//copper ion transport GO:0008270//GO:0004045//GO:0005507//GO:0016531 zinc ion binding//aminoacyl-tRNA hydrolase activity//copper ion binding//copper chaperone activity GO:0005758 mitochondrial intermembrane space KOG3282 Uncharacterized conserved protein Cluster-8309.53373 BF_2 31.21 1.22 1358 642929789 XP_008195977.1 340 3.3e-29 PREDICTED: oxysterol-binding protein-related protein 9 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A2A8Z1 175 1.8e-11 Oxysterol-binding protein-related protein 9 OS=Mus musculus GN=Osbpl9 PE=1 SV=1 PF03510 2C endopeptidase (C24) cysteine protease family GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.53374 BF_2 2.00 0.51 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53377 BF_2 32.47 0.69 2266 158291101 XP_312606.4 261 8.0e-20 AGAP002353-PA [Anopheles gambiae str. PEST]>gi|157018213|gb|EAA08216.4| AGAP002353-PA [Anopheles gambiae str. PEST] -- -- -- -- -- K01052 LIPA lysosomal acid lipase/cholesteryl ester hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01052 O46108 201 3.0e-14 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53380 BF_2 28.80 0.51 2643 642935612 XP_008198081.1 2274 3.5e-253 PREDICTED: probable elongator complex protein 2 [Tribolium castaneum]>gi|270013922|gb|EFA10370.1| hypothetical protein TcasGA2_TC012601 [Tribolium castaneum] 820980913 XM_012506317.1 42 5.36843e-10 PREDICTED: Nomascus leucogenys elongator acetyltransferase complex subunit 2 (ELP2), mRNA K11374 ELP2 elongator complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11374 Q7K4B3 1735 4.6e-192 Probable elongator complex protein 2 OS=Drosophila melanogaster GN=Elp2 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily Cluster-8309.53382 BF_2 22.08 0.52 2052 91078370 XP_974092.1 1641 6.9e-180 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003978|gb|EFA00426.1| hypothetical protein TcasGA2_TC003280 [Tribolium castaneum] 253560541 GQ232416.1 50 1.48276e-14 Culex pipiens pipiens putative acyl-CoA dehydrogenase (ACD-1) mRNA, partial cds K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1520 3.1e-167 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF08047//PF00441//PF02770 Histidine operon leader peptide//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0000105//GO:0055114//GO:0006118 histidine biosynthetic process//oxidation-reduction process//obsolete electron transport GO:0016627//GO:0050660//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.53383 BF_2 279.20 5.03 2609 642935612 XP_008198081.1 2423 1.8e-270 PREDICTED: probable elongator complex protein 2 [Tribolium castaneum]>gi|270013922|gb|EFA10370.1| hypothetical protein TcasGA2_TC012601 [Tribolium castaneum] 820980913 XM_012506317.1 42 5.29844e-10 PREDICTED: Nomascus leucogenys elongator acetyltransferase complex subunit 2 (ELP2), mRNA K11374 ELP2 elongator complex protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11374 Q7K4B3 1803 5.9e-200 Probable elongator complex protein 2 OS=Drosophila melanogaster GN=Elp2 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1063 RNA polymerase II elongator complex, subunit ELP2, WD repeat superfamily Cluster-8309.53386 BF_2 398.79 5.84 3146 642932460 XP_008197124.1 2253 1.1e-250 PREDICTED: LOW QUALITY PROTEIN: diacylglycerol kinase epsilon [Tribolium castaneum] -- -- -- -- -- K00901 dgkA, DGK diacylglycerol kinase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K00901 Q9R1C6 1022 2.6e-109 Diacylglycerol kinase epsilon OS=Mus musculus GN=Dgke PE=2 SV=1 PF00781//PF00609//PF00130 Diacylglycerol kinase catalytic domain//Diacylglycerol kinase accessory domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0007205//GO:0009395//GO:0046486//GO:0035556 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process//intracellular signal transduction GO:0016301//GO:0004143 kinase activity//diacylglycerol kinase activity -- -- KOG1169 Diacylglycerol kinase Cluster-8309.53388 BF_2 2.00 6.27 268 675386912 KFM79809.1 136 2.9e-06 Cathepsin L, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P13277 122 5.1e-06 Digestive cysteine proteinase 1 OS=Homarus americanus GN=LCP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.53389 BF_2 9.00 0.78 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53393 BF_2 54.36 0.52 4637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53401 BF_2 75.13 0.70 4752 642914114 XP_008201549.1 2831 0.0e+00 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X2 [Tribolium castaneum] 642914119 XM_008203330.1 483 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q68DX3 206 1.6e-14 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53402 BF_2 42.40 0.62 3134 270002194 EEZ98641.1 747 4.9e-76 hypothetical protein TcasGA2_TC001169 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q25255 134 2.4e-06 Peritrophin-44 OS=Lucilia cuprina PE=1 SV=1 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.53403 BF_2 19.32 0.39 2336 642914290 XP_008201624.1 570 1.2e-55 PREDICTED: uncharacterized protein LOC103315235 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.53406 BF_2 71.85 1.17 2864 642930216 XP_970192.2 1626 5.3e-178 PREDICTED: protein UBASH3A homolog isoform X1 [Tribolium castaneum] 642930215 XM_965099.2 283 6.21901e-144 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 1265 1.6e-137 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.53407 BF_2 7.00 0.76 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53408 BF_2 12.00 6.57 360 641650078 XP_001944276.3 213 4.6e-15 PREDICTED: uncharacterized protein LOC100160142 [Acyrthosiphon pisum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q64633 187 2.0e-13 UDP-glucuronosyltransferase 1-7 OS=Rattus norvegicus GN=Ugt1a7c PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.53409 BF_2 82.69 0.77 4784 332376639 AEE63459.1 1639 2.8e-179 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01081 E3.1.3.5 5'-nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01081 B3A0N5 1282 2.8e-139 Apyrase OS=Tabanus yao PE=1 SV=1 PF00149//PF01757//PF02872 Calcineurin-like phosphoesterase//Acyltransferase family//5'-nucleotidase, C-terminal domain GO:0009166 nucleotide catabolic process GO:0016747//GO:0016787 transferase activity, transferring acyl groups other than amino-acyl groups//hydrolase activity -- -- -- -- Cluster-8309.53411 BF_2 8.69 0.64 856 91082701 XP_971906.1 419 1.4e-38 PREDICTED: secretory carrier-associated membrane protein 1 [Tribolium castaneum]>gi|270015052|gb|EFA11500.1| hypothetical protein TcasGA2_TC014214 [Tribolium castaneum] 462332875 APGK01039175.1 89 1.26297e-36 Dendroctonus ponderosae Seq01039185, whole genome shotgun sequence -- -- -- -- O15126 190 2.1e-13 Secretory carrier-associated membrane protein 1 OS=Homo sapiens GN=SCAMP1 PE=1 SV=2 PF04144//PF00049 SCAMP family//Insulin/IGF/Relaxin family GO:0015031//GO:0007165 protein transport//signal transduction GO:0005179 hormone activity GO:0005576//GO:0016021 extracellular region//integral component of membrane KOG3088 Secretory carrier membrane protein Cluster-8309.53412 BF_2 54.24 1.47 1828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53418 BF_2 247.95 7.48 1673 728418014 AIY68354.1 1549 2.6e-169 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 B2D0J5 604 4.1e-61 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53419 BF_2 57.90 3.14 1058 728418014 AIY68354.1 533 1.1e-51 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53420 BF_2 29.64 0.37 3679 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53422 BF_2 35.00 0.32 4815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53426 BF_2 24.84 1.60 937 546671469 ERL83770.1 450 4.0e-42 hypothetical protein D910_01007, partial [Dendroctonus ponderosae]>gi|546683774|gb|ERL93534.1| hypothetical protein D910_10823, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53429 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53430 BF_2 94.35 3.39 1453 642930146 XP_008196271.1 1643 2.9e-180 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X5 [Tribolium castaneum] 189164165 EU545256.1 263 4.09254e-133 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1221 1.0e-132 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0003700//GO:0008270//GO:0043565 transcription factor activity, sequence-specific DNA binding//zinc ion binding//sequence-specific DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.53432 BF_2 38.00 0.78 2325 546671091 ERL83562.1 337 1.3e-28 hypothetical protein D910_00648 [Dendroctonus ponderosae]>gi|546671774|gb|ERL83943.1| hypothetical protein D910_01236 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53433 BF_2 145.88 6.41 1239 91086847 XP_974260.1 1027 6.6e-109 PREDICTED: BSD domain-containing protein 1-B [Tribolium castaneum]>gi|270010460|gb|EFA06908.1| hypothetical protein TcasGA2_TC009857 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BJ78 321 2.0e-28 BSD domain-containing protein 1 OS=Xenopus tropicalis GN=bsdc1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2690 Uncharacterized conserved protein, contains BSD domain Cluster-8309.53438 BF_2 11.03 0.35 1621 642930742 XP_008196074.1 517 1.2e-49 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- K04919 KCNK9 potassium channel subfamily K member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04919 O35111 189 5.3e-13 Potassium channel subfamily K member 3 OS=Mus musculus GN=Kcnk3 PE=2 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.53439 BF_2 77.41 0.73 4726 189235374 XP_001809693.1 1730 7.6e-190 PREDICTED: potassium voltage-gated channel protein Shaker isoform X1 [Tribolium castaneum] 642916511 XM_001809641.2 804 0 PREDICTED: Tribolium castaneum potassium voltage-gated channel protein Shaker (LOC100142279), transcript variant X1, mRNA K05318 KCNAN potassium voltage-gated channel Shaker-related subfamily A, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05318 P08510 1355 9.6e-148 Potassium voltage-gated channel protein Shaker OS=Drosophila melanogaster GN=Sh PE=1 SV=3 PF02214//PF00520 BTB/POZ domain//Ion transport protein GO:0051260//GO:0006811//GO:0055085 protein homooligomerization//ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.53442 BF_2 69.49 13.10 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02230 Phospholipase/Carboxylesterase -- -- GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.53443 BF_2 17.80 0.52 1731 91094587 XP_970350.1 710 5.3e-72 PREDICTED: high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A [Tribolium castaneum] 642939259 XM_965257.2 152 2.47915e-71 PREDICTED: Tribolium castaneum high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (LOC658906), mRNA K13761 PDE9 high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53444 BF_2 77.53 1.24 2906 642932510 XP_008197143.1 2229 6.4e-248 PREDICTED: chromosome transmission fidelity protein 18 homolog [Tribolium castaneum] -- -- -- -- -- K11269 CTF18, CHL12 chromosome transmission fidelity protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K11269 Q6NU40 1242 7.4e-135 Chromosome transmission fidelity protein 18 homolog OS=Xenopus laevis GN=chtf18 PE=2 SV=1 PF00004//PF07724//PF07728//PF01695//PF05496//PF08519//PF00910//PF00931//PF03193//PF03266//PF00005//PF06414 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Holliday junction DNA helicase ruvB N-terminus//Replication factor RFC1 C terminal domain//RNA helicase//NB-ARC domain//Protein of unknown function, DUF258//NTPase//ABC transporter//Zeta toxin GO:0006310//GO:0006281//GO:0006260 DNA recombination//DNA repair//DNA replication GO:0003723//GO:0043531//GO:0005525//GO:0003724//GO:0009378//GO:0098519//GO:0005524//GO:0003924//GO:0016887//GO:0016301//GO:0003689 RNA binding//ADP binding//GTP binding//RNA helicase activity//four-way junction helicase activity//nucleotide phosphatase activity, acting on free nucleotides//ATP binding//GTPase activity//ATPase activity//kinase activity//DNA clamp loader activity GO:0005657//GO:0009379//GO:0042575//GO:0005663 replication fork//Holliday junction helicase complex//DNA polymerase complex//DNA replication factor C complex KOG1969 DNA replication checkpoint protein CHL12/CTF18 Cluster-8309.53445 BF_2 85.76 3.71 1254 861599125 KMQ83546.1 659 3.1e-66 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53446 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53452 BF_2 157.63 3.54 2148 91080493 XP_970962.1 1392 5.4e-151 PREDICTED: bestrophin-3 [Tribolium castaneum]>gi|270005768|gb|EFA02216.1| hypothetical protein TcasGA2_TC007875 [Tribolium castaneum] -- -- -- -- -- K13879 BEST2, VMD2L1 bestrophin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K13879 Q8BGM5 883 2.3e-93 Bestrophin-2 OS=Mus musculus GN=Best2 PE=2 SV=1 PF00403 Heavy-metal-associated domain GO:0030001 metal ion transport GO:0046872 metal ion binding -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.53454 BF_2 165.77 4.29 1902 478251484 ENN71947.1 1955 2.5e-216 hypothetical protein YQE_11381, partial [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q8BYF6 903 9.9e-96 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.53456 BF_2 242.50 6.09 1953 478251484 ENN71947.1 1955 2.6e-216 hypothetical protein YQE_11381, partial [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q8BYF6 903 1.0e-95 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.53457 BF_2 252.65 4.61 2578 642916135 XP_008190901.1 765 3.3e-78 PREDICTED: PQ-loop repeat-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N755 308 1.3e-26 PQ-loop repeat-containing protein 3 OS=Homo sapiens GN=PQLC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.53464 BF_2 775.64 17.86 2104 642926149 XP_972125.2 1613 1.3e-176 PREDICTED: putative sodium-coupled neutral amino acid transporter 9 [Tribolium castaneum] -- -- -- -- -- K14995 SLC38A9 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K14995 Q19425 860 1.1e-90 Sodium-coupled neutral amino acid transporter 9 homolog OS=Caenorhabditis elegans GN=F13H10.3 PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53468 BF_2 4.46 0.37 790 642914939 XP_008190450.1 419 1.3e-38 PREDICTED: putative helicase mov-10-B.1 [Tribolium castaneum] -- -- -- -- -- K18422 MOV10 helicase MOV-10 http://www.genome.jp/dbget-bin/www_bget?ko:K18422 Q9HCE1 240 3.1e-19 Putative helicase MOV-10 OS=Homo sapiens GN=MOV10 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1804 RNA helicase Cluster-8309.53470 BF_2 9.00 2.24 455 767943397 XP_011534352.1 567 5.3e-56 PREDICTED: proto-oncogene tyrosine-protein kinase ROS isoform X2 [Homo sapiens] 584458492 NG_033929.1 455 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 567 2.2e-57 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53473 BF_2 199.53 5.26 1875 91079600 XP_968514.1 1115 6.2e-119 PREDICTED: transcription initiation factor TFIID subunit 7 [Tribolium castaneum]>gi|270004463|gb|EFA00911.1| hypothetical protein TcasGA2_TC003817 [Tribolium castaneum] -- -- -- -- -- K03132 TAF7 transcription initiation factor TFIID subunit 7 http://www.genome.jp/dbget-bin/www_bget?ko:K03132 Q9VHY5 467 3.5e-45 Transcription initiation factor TFIID subunit 7 OS=Drosophila melanogaster GN=Taf7 PE=1 SV=1 PF04658 TAFII55 protein conserved region GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005669 transcription factor TFIID complex KOG4011 Transcription initiation factor TFIID, subunit TAF7 Cluster-8309.53475 BF_2 90.44 2.65 1715 270015507 EFA11955.1 515 2.1e-49 hypothetical protein TcasGA2_TC008556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EQ28 214 7.0e-16 DNA polymerase delta subunit 3 OS=Mus musculus GN=Pold3 PE=1 SV=2 PF09507//PF17079//PF08689 DNA polymerase subunit Cdc27//Male-specific protein scotti//Mediator complex subunit Med5 GO:0006357//GO:0006260//GO:0007291 regulation of transcription from RNA polymerase II promoter//DNA replication//sperm individualization GO:0001104 RNA polymerase II transcription cofactor activity GO:0005634//GO:0016592 nucleus//mediator complex -- -- Cluster-8309.53476 BF_2 149.37 1.89 3594 642929960 XP_008196043.1 1035 2.3e-109 PREDICTED: uncharacterized protein LOC661554 [Tribolium castaneum] -- -- -- -- -- K07819 B3GALT1 beta-1,3-galactosyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07819 Q9Y5Z6 431 1.0e-40 Beta-1,3-galactosyltransferase 1 OS=Homo sapiens GN=B3GALT1 PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane -- -- Cluster-8309.53477 BF_2 322.78 2.87 4989 642934662 XP_008197757.1 4150 0.0e+00 PREDICTED: partitioning defective 3 homolog isoform X4 [Tribolium castaneum] 766917723 XM_011496118.1 51 1.01204e-14 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 659 5.1e-67 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF08727 PDZ domain (Also known as DHR or GLGF)//Poliovirus 3A protein like GO:0006144//GO:0006508 purine nucleobase metabolic process//proteolysis GO:0017111//GO:0005515//GO:0004197//GO:0003968 nucleoside-triphosphatase activity//protein binding//cysteine-type endopeptidase activity//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-8309.53478 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53480 BF_2 77.00 0.31 10678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845//PF04706 Spore germination protein//Dickkopf N-terminal cysteine-rich region GO:0009847//GO:0030178//GO:0007275 spore germination//negative regulation of Wnt signaling pathway//multicellular organismal development -- -- GO:0016021//GO:0005576 integral component of membrane//extracellular region -- -- Cluster-8309.53486 BF_2 150.57 1.01 6498 642924039 XP_008193981.1 1498 8.4e-163 PREDICTED: synaptic vesicle 2-related protein [Tribolium castaneum] 642924038 XM_008195759.1 265 1.44062e-133 PREDICTED: Tribolium castaneum synaptic vesicle 2-related protein (LOC100142592), mRNA -- -- -- -- Q9Z2I7 896 2.2e-94 Synaptic vesicle 2-related protein OS=Rattus norvegicus GN=Svop PE=1 SV=1 PF13417//PF00701//PF00083//PF02798//PF07690//PF13409 Glutathione S-transferase, N-terminal domain//Dihydrodipicolinate synthetase family//Sugar (and other) transporter//Glutathione S-transferase, N-terminal domain//Major Facilitator Superfamily//Glutathione S-transferase, N-terminal domain GO:0055085//GO:0008152 transmembrane transport//metabolic process GO:0005515//GO:0016829//GO:0022857 protein binding//lyase activity//transmembrane transporter activity GO:0016021 integral component of membrane KOG0253 Synaptic vesicle transporter SV2 (major facilitator superfamily) Cluster-8309.53487 BF_2 481.62 2.79 7504 91077676 XP_974586.1 2692 3.4e-301 PREDICTED: E3 ubiquitin-protein ligase RFWD2 isoform X1 [Tribolium castaneum]>gi|270001535|gb|EEZ97982.1| hypothetical protein TcasGA2_TC000377 [Tribolium castaneum] 821479846 XM_012547670.1 46 9.17963e-12 PREDICTED: Sarcophilus harrisii ring finger and WD repeat domain 2, E3 ubiquitin protein ligase (RFWD2), mRNA K10143 RFWD2, COP1 E3 ubiquitin-protein ligase RFWD2 http://www.genome.jp/dbget-bin/www_bget?ko:K10143 Q8NHY2 1693 9.7e-187 E3 ubiquitin-protein ligase RFWD2 OS=Homo sapiens GN=RFWD2 PE=1 SV=1 PF00097//PF12678//PF00883//PF04564//PF14634//PF02789//PF13639//PF16685//PF00048//PF00400//PF03823 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//Cytosol aminopeptidase family, catalytic domain//U-box domain//zinc-RING finger domain//Cytosol aminopeptidase family, N-terminal domain//Ring finger domain//zinc RING finger of MSL2//Small cytokines (intecrine/chemokine), interleukin-8 like//WD domain, G-beta repeat//Neurokinin B GO:0016567//GO:0006935//GO:0007165//GO:0007217//GO:0006508//GO:0006955 protein ubiquitination//chemotaxis//signal transduction//tachykinin receptor signaling pathway//proteolysis//immune response GO:0005515//GO:0061630//GO:0004842//GO:0008009//GO:0046872//GO:0004177//GO:0008270 protein binding//ubiquitin protein ligase activity//ubiquitin-protein transferase activity//chemokine activity//metal ion binding//aminopeptidase activity//zinc ion binding GO:0005622//GO:0005576 intracellular//extracellular region -- -- Cluster-8309.53491 BF_2 3.00 0.32 685 -- -- -- -- -- 60649821 AJ829764.1 72 2.82065e-27 Otiorhynchus sulcatus partial cbh1 gene for cellulose 1,4-beta-cellobiosidase, six exons -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53493 BF_2 337.06 4.34 3537 642932696 XP_008196948.1 1875 8.8e-207 PREDICTED: uncharacterized protein LOC660251 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF06330//PF02183//PF06367//PF10473//PF00926 Diaphanous GTPase-binding Domain//Trichodiene synthase (TRI5)//Homeobox associated leucine zipper//Diaphanous FH3 Domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//3,4-dihydroxy-2-butanone 4-phosphate synthase GO:0009231//GO:0016043//GO:0006355//GO:0030036//GO:0016106//GO:0016114 riboflavin biosynthetic process//cellular component organization//regulation of transcription, DNA-templated//actin cytoskeleton organization//sesquiterpenoid biosynthetic process//terpenoid biosynthetic process GO:0042803//GO:0017048//GO:0045482//GO:0043565//GO:0003700//GO:0008686//GO:0045502//GO:0003779//GO:0008134 protein homodimerization activity//Rho GTPase binding//trichodiene synthase activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//3,4-dihydroxy-2-butanone-4-phosphate synthase activity//dynein binding//actin binding//transcription factor binding GO:0030286//GO:0005667 dynein complex//transcription factor complex -- -- Cluster-8309.53495 BF_2 1.00 2.66 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53497 BF_2 32.34 1.02 1612 91082413 XP_976289.1 522 3.1e-50 PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922599|ref|XP_008193242.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922601|ref|XP_008193243.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922603|ref|XP_008193244.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922605|ref|XP_008193245.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|642922607|ref|XP_008193246.1| PREDICTED: uncharacterized protein LOC658581 [Tribolium castaneum]>gi|270007164|gb|EFA03612.1| hypothetical protein TcasGA2_TC013700 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53499 BF_2 20.03 0.56 1790 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643//PF10716 B-box zinc finger//NADH dehydrogenase transmembrane subunit GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0016655//GO:0008270 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.53500 BF_2 3.00 0.97 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53504 BF_2 8.00 2.17 441 759117207 XP_011357520.1 270 1.4e-21 PREDICTED: fibroblast growth factor receptor 2 isoform X6 [Pteropus vampyrus] 254553324 NG_012449.1 441 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 257 1.9e-21 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 PF07714//PF06817 Protein tyrosine kinase//Reverse transcriptase thumb domain GO:0006468//GO:0006278 protein phosphorylation//RNA-dependent DNA replication GO:0003964//GO:0004672 RNA-directed DNA polymerase activity//protein kinase activity -- -- -- -- Cluster-8309.53508 BF_2 266.88 3.60 3390 91085409 XP_967434.1 871 2.2e-90 PREDICTED: prostatic acid phosphatase [Tribolium castaneum]>gi|270009157|gb|EFA05605.1| hypothetical protein TcasGA2_TC015811 [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q3KQG9 633 3.6e-64 Testicular acid phosphatase homolog OS=Xenopus laevis GN=acpt PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.53509 BF_2 231.12 4.22 2577 91085409 XP_967434.1 861 2.4e-89 PREDICTED: prostatic acid phosphatase [Tribolium castaneum]>gi|270009157|gb|EFA05605.1| hypothetical protein TcasGA2_TC015811 [Tribolium castaneum] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 B1H1P9 622 5.2e-63 Lysosomal acid phosphatase OS=Xenopus laevis GN=acp2 PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.53510 BF_2 29.75 0.47 2960 270010999 EFA07447.1 462 5.2e-43 scarecrow [Tribolium castaneum] 736214483 XM_010779878.1 92 9.65014e-38 PREDICTED: Notothenia coriiceps NK2 homeobox 4 (nkx2-4), transcript variant X2, mRNA K09342 NKX2-1, TITF1 homeobox protein Nkx-2.1 http://www.genome.jp/dbget-bin/www_bget?ko:K09342 Q9H2Z4 276 7.8e-23 Homeobox protein Nkx-2.4 OS=Homo sapiens GN=NKX2-4 PE=3 SV=3 PF13374 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain Cluster-8309.53512 BF_2 192.64 1.93 4455 270001097 EEZ97544.1 925 1.6e-96 hypothetical protein TcasGA2_TC011394 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08240 Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process -- -- -- -- -- -- Cluster-8309.53515 BF_2 122.61 0.67 7921 642927844 XP_008195423.1 830 2.9e-85 PREDICTED: INO80 complex subunit D-B-like [Tribolium castaneum]>gi|270010242|gb|EFA06690.1| hypothetical protein TcasGA2_TC009621 [Tribolium castaneum] -- -- -- -- -- K11668 INO80D INO80 complex subunit D http://www.genome.jp/dbget-bin/www_bget?ko:K11668 Q66JY2 239 4.1e-18 INO80 complex subunit D OS=Mus musculus GN=Ino80d PE=2 SV=3 PF06160//PF00397 Septation ring formation regulator, EzrA//WW domain GO:0000921 septin ring assembly GO:0005515 protein binding GO:0016021//GO:0005940 integral component of membrane//septin ring -- -- Cluster-8309.53516 BF_2 411.14 4.32 4273 189239429 XP_974808.2 2351 6.8e-262 PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|642929453|ref|XP_008195847.1| PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|642929455|ref|XP_008195848.1| PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|642929457|ref|XP_008195849.1| PREDICTED: zinc finger protein 2 homolog [Tribolium castaneum]>gi|270009621|gb|EFA06069.1| hypothetical protein TcasGA2_TC008904 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80W31 751 9.4e-78 Zinc finger protein 569 OS=Mus musculus GN=Znf569 PE=2 SV=2 PF01781//PF00096//PF00582//PF02892//PF13912//PF16622//PF13465//PF05443 Ribosomal L38e protein family//Zinc finger, C2H2 type//Universal stress protein family//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//ROS/MUCR transcriptional regulator protein GO:0006355//GO:0042254//GO:0006950//GO:0006412 regulation of transcription, DNA-templated//ribosome biogenesis//response to stress//translation GO:0003735//GO:0008270//GO:0003676//GO:0046872//GO:0003677 structural constituent of ribosome//zinc ion binding//nucleic acid binding//metal ion binding//DNA binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.53522 BF_2 8.00 2.09 447 267822906 ACY79565.1 312 1.9e-26 mutant anaplastic lymphoma receptor tyrosine kinase [Homo sapiens] 221554531 NG_009445.1 444 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 312 7.9e-28 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53523 BF_2 716.06 12.53 2678 642910281 XP_008198657.1 2122 1.5e-235 PREDICTED: prolyl 3-hydroxylase 1-like [Tribolium castaneum] -- -- -- -- -- K08134 LEPRE leucine proline-enriched proteoglycan (leprecan) http://www.genome.jp/dbget-bin/www_bget?ko:K08134 Q6JHU7 921 1.1e-97 Prolyl 3-hydroxylase 2 OS=Gallus gallus GN=LEPREL1 PE=2 SV=1 PF00515//PF13640//PF03171//PF13414 Tetratricopeptide repeat//2OG-Fe(II) oxygenase superfamily//2OG-Fe(II) oxygenase superfamily//TPR repeat GO:0055114 oxidation-reduction process GO:0016491//GO:0005515 oxidoreductase activity//protein binding -- -- -- -- Cluster-8309.53524 BF_2 522.89 8.73 2793 478258925 ENN78905.1 2019 1.4e-223 hypothetical protein YQE_04643, partial [Dendroctonus ponderosae] -- -- -- -- -- K17923 SNX9_18_33 sorting nexin-9/18/33 http://www.genome.jp/dbget-bin/www_bget?ko:K17923 Q8I4E2 883 3.0e-93 Sorting nexin lst-4 OS=Caenorhabditis elegans GN=lst-4 PE=1 SV=1 PF00787//PF00018//PF14604 PX domain//SH3 domain//Variant SH3 domain -- -- GO:0035091//GO:0005515 phosphatidylinositol binding//protein binding -- -- KOG2273 Membrane coat complex Retromer, subunit VPS5/SNX1, Sorting nexins, and related PX domain-containing proteins Cluster-8309.53528 BF_2 241.11 8.10 1533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14862 Big defensin GO:0050830//GO:0050829 defense response to Gram-positive bacterium//defense response to Gram-negative bacterium -- -- -- -- -- -- Cluster-8309.53529 BF_2 302.73 7.33 2015 641668003 XP_008184291.1 170 2.5e-09 PREDICTED: uncharacterized protein LOC103309773 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53530 BF_2 25.18 0.93 1422 641668003 XP_008184291.1 170 1.8e-09 PREDICTED: uncharacterized protein LOC103309773 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53533 BF_2 455.63 5.01 4090 189234120 XP_968578.2 856 1.5e-88 PREDICTED: tetraspanin-13 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17356 TSPAN13_31 tetraspanin-13/31 http://www.genome.jp/dbget-bin/www_bget?ko:K17356 Q5XHG6 450 7.2e-43 Tetraspanin-31-A OS=Xenopus laevis GN=tspan31-a PE=2 SV=1 PF11837//PF00335//PF07574//PF11654//PF00076 Domain of unknown function (DUF3357)//Tetraspanin family//Nse1 non-SMC component of SMC5-6 complex//Protein of unknown function (DUF2665)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006012//GO:0005985//GO:0005982//GO:0006281//GO:0009306 galactose metabolic process//sucrose metabolic process//starch metabolic process//DNA repair//protein secretion GO:0004575//GO:0003676//GO:0004564 sucrose alpha-glucosidase activity//nucleic acid binding//beta-fructofuranosidase activity GO:0030915//GO:0016021//GO:0017177 Smc5-Smc6 complex//integral component of membrane//glucosidase II complex KOG4208 Nucleolar RNA-binding protein NIFK Cluster-8309.53534 BF_2 222.00 32.71 571 21617525 AAM66719.1 534 4.4e-52 larval cuticle protein 12.6 [Apriona germari] -- -- -- -- -- -- -- -- -- O02387 248 2.7e-20 Larval cuticle protein LCP-17 OS=Bombyx mori GN=LCP17 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.53535 BF_2 130.22 1.08 5315 242008211 XP_002424904.1 2464 6.6e-275 zinc finger protein, putative [Pediculus humanus corporis]>gi|212508484|gb|EEB12166.1| zinc finger protein, putative [Pediculus humanus corporis] 817192597 XM_012416318.1 430 0 PREDICTED: Orussus abietinus zinc finger protein 665-like (LOC105695064), transcript variant X6, mRNA -- -- -- -- P51523 1365 7.4e-149 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF13912//PF06467 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0008270//GO:0005488 metal ion binding//zinc ion binding//binding -- -- -- -- Cluster-8309.53537 BF_2 11.14 0.32 1741 91094771 XP_967866.1 1686 3.5e-185 PREDICTED: protein shifted isoform X2 [Tribolium castaneum]>gi|270016572|gb|EFA13018.1| shifted [Tribolium castaneum] -- -- -- -- -- K01691 WIF1 WNT inhibitory factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K01691 Q9W3W5 1046 2.4e-112 Protein shifted OS=Drosophila melanogaster GN=shf PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.53543 BF_2 14.00 2.86 492 270009040 EFA05488.1 809 5.0e-84 hypothetical protein TcasGA2_TC015673 [Tribolium castaneum] 817195439 XM_012417832.1 131 3.16809e-60 PREDICTED: Orussus abietinus peptidylprolyl isomerase domain and WD repeat-containing protein 1 (LOC105695851), transcript variant X2, mRNA K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q29RZ2 683 8.3e-71 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Bos taurus GN=PPWD1 PE=2 SV=1 PF00160 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GO:0006457//GO:0000413 protein folding//protein peptidyl-prolyl isomerization GO:0003755 peptidyl-prolyl cis-trans isomerase activity -- -- KOG0881 Cyclophilin type peptidyl-prolyl cis-trans isomerase Cluster-8309.53544 BF_2 68.13 1.91 1783 189238464 XP_966906.2 1975 1.1e-218 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q8CEC6 1468 2.8e-161 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Mus musculus GN=Ppwd1 PE=2 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.53547 BF_2 6.00 10.45 291 478259707 ENN79551.1 134 5.5e-06 hypothetical protein YQE_04013, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53549 BF_2 10.00 17.83 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53550 BF_2 380.00 17.90 1175 642924860 XP_008194071.1 296 3.6e-24 PREDICTED: uncharacterized protein LOC656855 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53552 BF_2 4.00 7.13 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53553 BF_2 63.96 9.36 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53555 BF_2 10.00 28.83 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53556 BF_2 2.00 3.33 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53557 BF_2 31.04 18.76 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53558 BF_2 1.00 5.13 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53562 BF_2 731.68 6.43 5045 642919181 XP_008191771.1 3088 0.0e+00 PREDICTED: uncharacterized protein LOC103312580 isoform X1 [Tribolium castaneum]>gi|270005582|gb|EFA02030.1| hypothetical protein TcasGA2_TC007655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5357 BF_2 50.00 2.30 1197 642932906 XP_008197181.1 1459 5.1e-159 PREDICTED: replication factor C subunit 5 [Tribolium castaneum] -- -- -- -- -- K10756 RFC3_5 replication factor C subunit 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10756 P40937 1212 9.2e-132 Replication factor C subunit 5 OS=Homo sapiens GN=RFC5 PE=1 SV=1 PF07726//PF02562//PF04851//PF00270//PF01695//PF07728//PF05496//PF06068//PF00004//PF06144 ATPase family associated with various cellular activities (AAA)//PhoH-like protein//Type III restriction enzyme, res subunit//DEAD/DEAH box helicase//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//DNA polymerase III, delta subunit GO:0006310//GO:0006260//GO:0006281 DNA recombination//DNA replication//DNA repair GO:0009378//GO:0016887//GO:0003676//GO:0003887//GO:0003678//GO:0005524//GO:0016787//GO:0003677 four-way junction helicase activity//ATPase activity//nucleic acid binding//DNA-directed DNA polymerase activity//DNA helicase activity//ATP binding//hydrolase activity//DNA binding GO:0042575//GO:0005657//GO:0009379//GO:0009360 DNA polymerase complex//replication fork//Holliday junction helicase complex//DNA polymerase III complex KOG0990 Replication factor C, subunit RFC5 Cluster-8309.53573 BF_2 76.44 0.37 8901 478256070 ENN76269.1 1358 2.0e-146 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P25386 268 2.0e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF06220//PF06657//PF01025//PF00866//PF03623//PF05837//PF01008//PF10473//PF04508//PF01576//PF00170//PF16331//PF04111//PF07851 U1 zinc finger//Centrosome microtubule-binding domain of Cep57//GrpE//Ring hydroxylating beta subunit//Focal adhesion targeting region//Centromere protein H (CENP-H)//Initiation factor 2 subunit family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Viral A-type inclusion protein repeat//Myosin tail//bZIP transcription factor//TolA binding protein trimerisation//Autophagy protein Apg6//TMPIT-like protein GO:0006457//GO:0006355//GO:0006914//GO:0006468//GO:0070206//GO:0007165//GO:0006725//GO:0007172//GO:0016032//GO:0055114//GO:0044237//GO:0051382 protein folding//regulation of transcription, DNA-templated//autophagy//protein phosphorylation//protein trimerization//signal transduction//cellular aromatic compound metabolic process//signal complex assembly//viral process//oxidation-reduction process//cellular metabolic process//kinetochore assembly GO:0042803//GO:0008017//GO:0004871//GO:0003824//GO:0004713//GO:0008270//GO:0043565//GO:0000774//GO:0003774//GO:0003700//GO:0051087//GO:0045502//GO:0008134 protein homodimerization activity//microtubule binding//signal transducer activity//catalytic activity//protein tyrosine kinase activity//zinc ion binding//sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//motor activity//transcription factor activity, sequence-specific DNA binding//chaperone binding//dynein binding//transcription factor binding GO:0016021//GO:0016459//GO:0000776//GO:0005667//GO:0030286//GO:0045298//GO:0005925 integral component of membrane//myosin complex//kinetochore//transcription factor complex//dynein complex//tubulin complex//focal adhesion -- -- Cluster-8309.53577 BF_2 10.00 0.52 1089 478256070 ENN76269.1 330 3.8e-28 hypothetical protein YQE_07234, partial [Dendroctonus ponderosae]>gi|546676002|gb|ERL87097.1| hypothetical protein D910_04497 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01025//PF00170//PF06657//PF03938//PF07851//PF04111 GrpE//bZIP transcription factor//Centrosome microtubule-binding domain of Cep57//Outer membrane protein (OmpH-like)//TMPIT-like protein//Autophagy protein Apg6 GO:0006355//GO:0006914//GO:0006457 regulation of transcription, DNA-templated//autophagy//protein folding GO:0003700//GO:0043565//GO:0051087//GO:0042803//GO:0051082//GO:0000774//GO:0008017 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//chaperone binding//protein homodimerization activity//unfolded protein binding//adenyl-nucleotide exchange factor activity//microtubule binding GO:0005667//GO:0045298//GO:0016021 transcription factor complex//tubulin complex//integral component of membrane -- -- Cluster-8309.53578 BF_2 429.19 5.58 3504 91083291 XP_974527.1 4089 0.0e+00 PREDICTED: exostosin-3 [Tribolium castaneum]>gi|270006943|gb|EFA03391.1| hypothetical protein TcasGA2_TC013377 [Tribolium castaneum] 571553454 XM_006564456.1 197 4.89167e-96 PREDICTED: Apis mellifera tripeptidyl-peptidase 2 (TppII), mRNA K02370 EXTL3 alpha-1,4-N-acetylglucosaminyltransferase EXTL3 http://www.genome.jp/dbget-bin/www_bget?ko:K02370 Q9XZ08 3068 0.0e+00 Exostosin-3 OS=Drosophila melanogaster GN=botv PE=1 SV=1 PF09258//PF08300//PF05615//PF04111 Glycosyl transferase family 64 domain//Hepatitis C virus non-structural 5a zinc finger domain//Tho complex subunit 7//Autophagy protein Apg6 GO:0015012//GO:0006397//GO:0006024//GO:0006914 heparan sulfate proteoglycan biosynthetic process//mRNA processing//glycosaminoglycan biosynthetic process//autophagy GO:0016758//GO:0008270 transferase activity, transferring hexosyl groups//zinc ion binding GO:0016021//GO:0031227//GO:0000445 integral component of membrane//intrinsic component of endoplasmic reticulum membrane//THO complex part of transcription export complex KOG1022 Acetylglucosaminyltransferase EXT2/exostosin 2 Cluster-8309.53579 BF_2 42.15 0.56 3433 91083291 XP_974527.1 2172 3.1e-241 PREDICTED: exostosin-3 [Tribolium castaneum]>gi|270006943|gb|EFA03391.1| hypothetical protein TcasGA2_TC013377 [Tribolium castaneum] 571553454 XM_006564456.1 197 4.79152e-96 PREDICTED: Apis mellifera tripeptidyl-peptidase 2 (TppII), mRNA K02370 EXTL3 alpha-1,4-N-acetylglucosaminyltransferase EXTL3 http://www.genome.jp/dbget-bin/www_bget?ko:K02370 Q9XZ08 1535 9.3e-169 Exostosin-3 OS=Drosophila melanogaster GN=botv PE=1 SV=1 PF06810//PF09258//PF05615//PF08300//PF04111 Phage minor structural protein GP20//Glycosyl transferase family 64 domain//Tho complex subunit 7//Hepatitis C virus non-structural 5a zinc finger domain//Autophagy protein Apg6 GO:0006024//GO:0006914//GO:0015012//GO:0006397 glycosaminoglycan biosynthetic process//autophagy//heparan sulfate proteoglycan biosynthetic process//mRNA processing GO:0008270//GO:0005198//GO:0016758 zinc ion binding//structural molecule activity//transferase activity, transferring hexosyl groups GO:0000445//GO:0031227//GO:0016021 THO complex part of transcription export complex//intrinsic component of endoplasmic reticulum membrane//integral component of membrane KOG1022 Acetylglucosaminyltransferase EXT2/exostosin 2 Cluster-8309.53580 BF_2 16.00 12.82 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06416 Protein of unknown function (DUF1076) GO:0072519//GO:0016567 parasitism//protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- -- -- Cluster-8309.53581 BF_2 6.00 0.54 756 559163445 AHB11276.1 155 5.2e-08 attacin-like immune protein [Diabrotica virgifera virgifera] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53585 BF_2 137.16 0.49 12062 642935135 XP_008197902.1 8205 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 13B isoform X1 [Tribolium castaneum] -- -- -- -- -- K19526 VPS13B vacuolar protein sorting-associated protein 13B http://www.genome.jp/dbget-bin/www_bget?ko:K19526 Q80TY5 1024 5.9e-109 Vacuolar protein sorting-associated protein 13B OS=Mus musculus GN=Vps13b PE=2 SV=2 -- -- -- -- -- -- -- -- KOG1809 Vacuolar protein sorting-associated protein Cluster-8309.53590 BF_2 132.53 15.67 641 270002181 EEZ98628.1 466 3.8e-44 hypothetical protein TcasGA2_TC001151, partial [Tribolium castaneum] -- -- -- -- -- K18168 SDHAF2, SDH5 succinate dehydrogenase assembly factor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18168 B4GDB3 385 3.9e-36 Succinate dehydrogenase assembly factor 2-A, mitochondrial OS=Drosophila persimilis GN=GL10881 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3326 Uncharacterized conserved protein Cluster-8309.53592 BF_2 12.62 0.38 1691 91078258 XP_970899.1 942 6.4e-99 PREDICTED: conserved oligomeric Golgi complex subunit 6 [Tribolium castaneum]>gi|270003921|gb|EFA00369.1| hypothetical protein TcasGA2_TC003211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V564 760 3.4e-79 Conserved oligomeric Golgi complex subunit 6 OS=Drosophila melanogaster GN=CG1968 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3758 Uncharacterized conserved protein Cluster-8309.53593 BF_2 10.84 1.45 599 189239794 XP_969790.2 307 9.8e-26 PREDICTED: histone-lysine N-methyltransferase eggless-like [Tribolium castaneum]>gi|642930862|ref|XP_008196116.1| PREDICTED: histone-lysine N-methyltransferase eggless-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32KD2 130 1.3e-06 Histone-lysine N-methyltransferase eggless OS=Drosophila melanogaster GN=egg PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53602 BF_2 39.63 0.34 5104 815769358 XP_012234792.1 1736 1.7e-190 PREDICTED: synaptotagmin-7 isoform X3 [Linepithema humile]>gi|815769360|ref|XP_012234793.1| PREDICTED: synaptotagmin-7 isoform X3 [Linepithema humile] 768417764 XM_011551234.1 438 0 PREDICTED: Plutella xylostella synaptotagmin-7 (LOC105381501), transcript variant X2, mRNA -- -- -- -- O43581 870 1.8e-91 Synaptotagmin-7 OS=Homo sapiens GN=SYT7 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.53606 BF_2 4.00 0.50 619 -- -- -- -- -- 685042148 LN590673.1 36 2.60743e-07 Cyprinus carpio genome assembly common carp genome ,scaffold LG45 -- -- -- -- -- -- -- -- PF00558 Vpu protein GO:0006812//GO:0032801//GO:0019076 cation transport//receptor catabolic process//viral release from host cell GO:0005261 cation channel activity GO:0033644 host cell membrane -- -- Cluster-8309.53607 BF_2 87.91 1.00 3953 478253469 ENN73796.1 2091 8.8e-232 hypothetical protein YQE_09574, partial [Dendroctonus ponderosae] -- -- -- -- -- K08863 PLK4 polo-like kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08863 A2VDZ4 1244 5.9e-135 Serine/threonine-protein kinase PLK4 OS=Bos taurus GN=PLK4 PE=2 SV=1 PF00069//PF00050//PF06293//PF07648//PF07714 Protein kinase domain//Kazal-type serine protease inhibitor domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Kazal-type serine protease inhibitor domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0016773//GO:0005524 protein binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding GO:0016020 membrane KOG0575 Polo-like serine/threonine protein kinase Cluster-8309.53611 BF_2 8.20 0.44 1071 546681997 ERL91993.1 475 5.8e-45 hypothetical protein D910_09315 [Dendroctonus ponderosae] -- -- -- -- -- K12231 HECTD1 E3 ubiquitin-protein ligase HECTD1 http://www.genome.jp/dbget-bin/www_bget?ko:K12231 Q69ZR2 412 4.8e-39 E3 ubiquitin-protein ligase HECTD1 OS=Mus musculus GN=Hectd1 PE=1 SV=2 PF00632 HECT-domain (ubiquitin-transferase) GO:0016567 protein ubiquitination GO:0004842 ubiquitin-protein transferase activity -- -- KOG0170 E3 ubiquitin protein ligase Cluster-8309.53615 BF_2 312.30 1.47 9176 91080871 XP_972325.1 2663 9.6e-298 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 4.5e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF02257//PF06119//PF01731//PF07645//PF00008 RFX DNA-binding domain//Nidogen-like//Arylesterase//Calcium-binding EGF domain//EGF-like domain GO:0007160//GO:0006355 cell-matrix adhesion//regulation of transcription, DNA-templated GO:0005515//GO:0004064//GO:0003677//GO:0005509 protein binding//arylesterase activity//DNA binding//calcium ion binding -- -- KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.53618 BF_2 96.73 1.09 3998 642932892 XP_008197175.1 730 5.8e-74 PREDICTED: uncharacterized protein LOC103314074 [Tribolium castaneum]>gi|270011476|gb|EFA07924.1| hypothetical protein TcasGA2_TC005502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53620 BF_2 120.63 2.70 2158 91079744 XP_970506.1 1271 5.8e-137 PREDICTED: probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial [Tribolium castaneum]>gi|270003324|gb|EEZ99771.1| hypothetical protein TcasGA2_TC002547 [Tribolium castaneum] 253560541 GQ232416.1 50 1.56068e-14 Culex pipiens pipiens putative acyl-CoA dehydrogenase (ACD-1) mRNA, partial cds K00249 ACADM, acd acyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00249 Q9VSA3 1240 9.4e-135 Probable medium-chain specific acyl-CoA dehydrogenase, mitochondrial OS=Drosophila melanogaster GN=CG12262 PE=1 SV=1 PF08047//PF02771//PF00441//PF02770 Histidine operon leader peptide//Acyl-CoA dehydrogenase, N-terminal domain//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0008152//GO:0006118//GO:0000105//GO:0055114 metabolic process//obsolete electron transport//histidine biosynthetic process//oxidation-reduction process GO:0050660//GO:0003995//GO:0016627 flavin adenine dinucleotide binding//acyl-CoA dehydrogenase activity//oxidoreductase activity, acting on the CH-CH group of donors -- -- KOG0140 Medium-chain acyl-CoA dehydrogenase Cluster-8309.53621 BF_2 8.00 1.65 490 593707575 XP_007100428.1 249 4.2e-19 PREDICTED: RAC-alpha serine/threonine-protein kinase [Physeter catodon] 15282126 AL590327.3 490 0 Human chromosome 14 DNA sequence Partial sequence from BAC C-2507D9 of library CalTech-D from chromosome 14 of Homo sapiens (Human), complete sequence K04456 AKT RAC serine/threonine-protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04456 P31749 236 5.6e-19 RAC-alpha serine/threonine-protein kinase OS=Homo sapiens GN=AKT1 PE=1 SV=2 PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain GO:0046373//GO:0005975//GO:0009117 L-arabinose metabolic process//carbohydrate metabolic process//nucleotide metabolic process GO:0046556 alpha-L-arabinofuranosidase activity -- -- -- -- Cluster-8309.53623 BF_2 77.30 0.55 6143 642911905 XP_008199016.1 3231 0.0e+00 PREDICTED: protein pigeon isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24118 1736 8.2e-192 Protein pigeon OS=Drosophila melanogaster GN=pigeon PE=2 SV=2 PF03374//PF15494//PF00278//PF02784 Phage antirepressor protein KilAC domain//Scavenger receptor cysteine-rich domain//Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Pyridoxal-dependent decarboxylase, pyridoxal binding domain -- -- GO:0003677//GO:0003824 DNA binding//catalytic activity GO:0016020 membrane KOG0622 Ornithine decarboxylase Cluster-8309.53624 BF_2 76.99 0.37 9032 642911905 XP_008199016.1 3231 0.0e+00 PREDICTED: protein pigeon isoform X1 [Tribolium castaneum] -- -- -- -- -- K01581 E4.1.1.17, ODC1, speC, speF ornithine decarboxylase http://www.genome.jp/dbget-bin/www_bget?ko:K01581 Q24118 1736 1.2e-191 Protein pigeon OS=Drosophila melanogaster GN=pigeon PE=2 SV=2 PF02784//PF03374//PF00278//PF15494 Pyridoxal-dependent decarboxylase, pyridoxal binding domain//Phage antirepressor protein KilAC domain//Pyridoxal-dependent decarboxylase, C-terminal sheet domain//Scavenger receptor cysteine-rich domain -- -- GO:0003824//GO:0003677 catalytic activity//DNA binding GO:0016020 membrane KOG0622 Ornithine decarboxylase Cluster-8309.53628 BF_2 364.17 4.06 4036 642917674 XP_008193576.1 1251 2.3e-134 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 4-like [Tribolium castaneum] -- -- -- -- -- K15426 PPP4R4 serine/threonine-protein phosphatase 4 regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15426 Q8C0Y0 745 4.4e-77 Serine/threonine-protein phosphatase 4 regulatory subunit 4 OS=Mus musculus GN=Ppp4r4 PE=2 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3040 Predicted sugar phosphatase (HAD superfamily) Cluster-8309.53631 BF_2 9.09 1.45 550 91079768 XP_966889.1 254 1.3e-19 PREDICTED: 15-hydroxyprostaglandin dehydrogenase [NAD(+)] [Tribolium castaneum]>gi|270004514|gb|EFA00962.1| hypothetical protein TcasGA2_TC003872 [Tribolium castaneum] -- -- -- -- -- K00069 HPGD 15-hydroxyprostaglandin dehydrogenase (NAD) http://www.genome.jp/dbget-bin/www_bget?ko:K00069 O08699 188 2.3e-13 15-hydroxyprostaglandin dehydrogenase [NAD(+)] OS=Rattus norvegicus GN=Hpgd PE=2 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- KOG4169 15-hydroxyprostaglandin dehydrogenase and related dehydrogenases Cluster-8309.53633 BF_2 11.90 0.33 1799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-8309.53634 BF_2 30.27 0.36 3810 189239531 XP_975588.2 1302 2.6e-140 PREDICTED: myb-related protein B isoform X1 [Tribolium castaneum] 817200908 XM_012420764.1 89 5.79494e-36 PREDICTED: Orussus abietinus myb-related protein B (LOC105697441), transcript variant X2, mRNA K09420 MYB myb proto-oncogene protein http://www.genome.jp/dbget-bin/www_bget?ko:K09420 P01103 467 7.2e-45 Transcriptional activator Myb OS=Gallus gallus GN=MYB PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0048 Transcription factor, Myb superfamily Cluster-8309.53635 BF_2 96.96 4.51 1187 642919343 XP_008191832.1 1188 1.3e-127 PREDICTED: alpha-N-acetylglucosaminidase isoform X1 [Tribolium castaneum]>gi|270005801|gb|EFA02249.1| hypothetical protein TcasGA2_TC007912 [Tribolium castaneum] -- -- -- -- -- K01205 NAGLU alpha-N-acetylglucosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01205 P54802 844 4.3e-89 Alpha-N-acetylglucosaminidase OS=Homo sapiens GN=NAGLU PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2233 Alpha-N-acetylglucosaminidase Cluster-8309.53637 BF_2 5.00 0.32 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53641 BF_2 91.00 2.39 1879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53642 BF_2 222.00 7.18 1581 332373460 AEE61871.1 968 5.8e-102 unknown [Dendroctonus ponderosae] -- -- -- -- -- K04708 E1.1.1.102 3-dehydrosphinganine reductase http://www.genome.jp/dbget-bin/www_bget?ko:K04708 Q06136 698 4.9e-72 3-ketodihydrosphingosine reductase OS=Homo sapiens GN=KDSR PE=1 SV=1 PF13241//PF02737//PF03435//PF00106//PF12242//PF02882 Putative NAD(P)-binding//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//Saccharopine dehydrogenase NADP binding domain//short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0006631//GO:0006552//GO:0008152//GO:0019354//GO:0006633//GO:0018874//GO:0006568//GO:0055114//GO:0006779//GO:0006554//GO:0006550//GO:0006574//GO:0046487//GO:0009396 fatty acid metabolic process//leucine catabolic process//metabolic process//siroheme biosynthetic process//fatty acid biosynthetic process//benzoate metabolic process//tryptophan metabolic process//oxidation-reduction process//porphyrin-containing compound biosynthetic process//lysine catabolic process//isoleucine catabolic process//valine catabolic process//glyoxylate metabolic process//folic acid-containing compound biosynthetic process GO:0003824//GO:0043115//GO:0016491//GO:0003857//GO:0004488 catalytic activity//precorrin-2 dehydrogenase activity//oxidoreductase activity//3-hydroxyacyl-CoA dehydrogenase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG1210 Predicted 3-ketosphinganine reductase Cluster-8309.53647 BF_2 3.00 5.35 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53648 BF_2 20.69 0.61 1695 642929765 XP_008195966.1 1154 1.7e-123 PREDICTED: protein fem-1 homolog B isoform X1 [Tribolium castaneum]>gi|270009534|gb|EFA05982.1| hypothetical protein TcasGA2_TC008808 [Tribolium castaneum] -- -- -- -- -- K10349 FEM1B Fem-1 homolog b http://www.genome.jp/dbget-bin/www_bget?ko:K10349 Q5ZM55 719 1.9e-74 Protein fem-1 homolog B OS=Gallus gallus GN=FEM1B PE=2 SV=1 PF13374 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG0508 Ankyrin repeat protein Cluster-8309.53652 BF_2 12.39 0.76 968 751233858 XP_011170631.1 323 2.2e-27 PREDICTED: uncharacterized protein LOC105203526 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53655 BF_2 237.68 9.60 1323 478254454 ENN74706.1 323 3.0e-27 hypothetical protein YQE_08823, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5E965 165 2.6e-10 Cytochrome b561 domain-containing protein 2 OS=Bos taurus GN=CYB561D2 PE=2 SV=1 PF05656//PF05297//PF03188//PF04186 Protein of unknown function (DUF805)//Herpesvirus latent membrane protein 1 (LMP1)//Eukaryotic cytochrome b561//FxsA cytoplasmic membrane protein GO:0019087 transformation of host cell by virus -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.53656 BF_2 8.00 0.88 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53658 BF_2 46.00 1.48 1591 546685244 ERL94771.1 1395 1.8e-151 hypothetical protein D910_12045 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DCC6 795 2.8e-83 Putative GTP-binding protein 6 OS=Xenopus laevis GN=gtpbp6 PE=2 SV=1 PF02421//PF03851//PF04661//PF01637//PF01926//PF00005 Ferrous iron transport protein B//UV-endonuclease UvdE//Poxvirus I3 ssDNA-binding protein//Archaeal ATPase//50S ribosome-binding GTPase//ABC transporter GO:0006289//GO:0015684//GO:0009411 nucleotide-excision repair//ferrous iron transport//response to UV GO:0005525//GO:0016887//GO:0004519//GO:0015093//GO:0005524//GO:0003697 GTP binding//ATPase activity//endonuclease activity//ferrous iron transmembrane transporter activity//ATP binding//single-stranded DNA binding GO:0016021 integral component of membrane KOG0410 Predicted GTP binding protein Cluster-8309.53663 BF_2 119.13 2.78 2079 478250264 ENN70764.1 872 1.0e-90 hypothetical protein YQE_12552, partial [Dendroctonus ponderosae]>gi|546685959|gb|ERL95373.1| hypothetical protein D910_12637 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D3D0 235 3.1e-18 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53664 BF_2 2.00 0.39 504 270004279 EFA00727.1 236 1.4e-17 hypothetical protein TcasGA2_TC003608 [Tribolium castaneum] -- -- -- -- -- K06071 PKN protein kinase N http://www.genome.jp/dbget-bin/www_bget?ko:K06071 A1Z7T0 183 8.1e-13 Serine/threonine-protein kinase N OS=Drosophila melanogaster GN=Pkn PE=1 SV=1 PF00433 Protein kinase C terminal domain GO:0009069//GO:0006468//GO:0016310 serine family amino acid metabolic process//protein phosphorylation//phosphorylation GO:0005524//GO:0004674 ATP binding//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.53667 BF_2 4.00 1.87 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53668 BF_2 606.68 6.99 3918 546680539 ERL90799.1 921 4.1e-96 hypothetical protein D910_08145 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.53669 BF_2 78.00 3.05 1357 91077210 XP_973096.1 1241 1.1e-133 PREDICTED: NAD-dependent protein deacetylase Sirt6 [Tribolium castaneum]>gi|270002055|gb|EEZ98502.1| hypothetical protein TcasGA2_TC001003 [Tribolium castaneum] -- -- -- -- -- K11416 SIRT6, SIR2L6 mono-ADP-ribosyltransferase sirtuin 6 http://www.genome.jp/dbget-bin/www_bget?ko:K11416 Q9VH08 1001 3.1e-107 NAD-dependent protein deacetylase Sirt6 OS=Drosophila melanogaster GN=Sirt6 PE=2 SV=1 PF10120//PF02146//PF00205 Thiamine-phosphate synthase//Sir2 family//Thiamine pyrophosphate enzyme, central domain -- -- GO:0004789//GO:0070403//GO:0000287//GO:0030976 thiamine-phosphate diphosphorylase activity//NAD+ binding//magnesium ion binding//thiamine pyrophosphate binding -- -- KOG1905 Class IV sirtuins (SIR2 family) Cluster-8309.53670 BF_2 37.60 4.92 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53671 BF_2 7.00 1.11 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53672 BF_2 339.18 8.19 2020 91087581 XP_971751.1 857 5.5e-89 PREDICTED: peroxisomal membrane protein PMP34 [Tribolium castaneum]>gi|270009432|gb|EFA05880.1| hypothetical protein TcasGA2_TC008692 [Tribolium castaneum] -- -- -- -- -- K13354 SLC25A17, PMP34 solute carrier family 25 (peroxisomal adenine nucleotide transporter), member 17 http://www.genome.jp/dbget-bin/www_bget?ko:K13354 O70579 587 4.6e-59 Peroxisomal membrane protein PMP34 OS=Mus musculus GN=Slc25a17 PE=2 SV=1 PF03201 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase GO:0015948//GO:0055114//GO:0046656 methanogenesis//oxidation-reduction process//folic acid biosynthetic process GO:0047068//GO:0018537 N5,N10-methenyltetrahydromethanopterin hydrogenase activity//coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity GO:0016020 membrane KOG0769 Predicted mitochondrial carrier protein Cluster-8309.53676 BF_2 978.32 12.36 3597 546674389 ERL85776.1 3698 0.0e+00 hypothetical protein D910_03191 [Dendroctonus ponderosae] 642926086 XM_001808290.2 513 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase TAO1 (LOC657810), mRNA K04429 TAO thousand and one amino acid protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04429 O88664 1304 6.0e-142 Serine/threonine-protein kinase TAO1 OS=Rattus norvegicus GN=Taok1 PE=1 SV=1 PF12474//PF07714//PF00069 Polo kinase kinase//Protein tyrosine kinase//Protein kinase domain GO:0016310//GO:0009069//GO:0006468 phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004672//GO:0004674//GO:0005524 protein kinase activity//protein serine/threonine kinase activity//ATP binding -- -- KOG0577 Serine/threonine protein kinase Cluster-8309.53681 BF_2 87.00 3.94 1210 242015011 XP_002428172.1 1118 1.8e-119 serine/threonine-protein kinase NIM1, putative [Pediculus humanus corporis]>gi|212512715|gb|EEB15434.1| serine/threonine-protein kinase NIM1, putative [Pediculus humanus corporis] 642926091 XM_008196541.1 428 0 PREDICTED: Tribolium castaneum MAP/microtubule affinity-regulating kinase 3 (LOC100142375), mRNA K19009 SIK3 serine/threonine-protein kinase SIK3 http://www.genome.jp/dbget-bin/www_bget?ko:K19009 Q6NSM8 1031 9.1e-111 Serine/threonine-protein kinase SIK3 homolog OS=Danio rerio GN=zgc:66101 PE=2 SV=1 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0016310//GO:0006468//GO:0009069 phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0004672//GO:0005524//GO:0004683 phosphotransferase activity, alcohol group as acceptor//protein kinase activity//ATP binding//calmodulin-dependent protein kinase activity GO:0016020 membrane KOG0586 Serine/threonine protein kinase Cluster-8309.53682 BF_2 395.32 4.50 3965 642926092 XP_008194763.1 2104 2.7e-233 PREDICTED: MAP/microtubule affinity-regulating kinase 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5REX1 141 4.7e-07 Serine/threonine-protein kinase SIK2 OS=Pongo abelii GN=SIK2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53683 BF_2 95.00 3.23 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03742 PetN GO:0017004//GO:0006118 cytochrome complex assembly//obsolete electron transport GO:0045158 electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity GO:0009512 cytochrome b6f complex -- -- Cluster-8309.53689 BF_2 8.36 0.46 1041 634006821 AHZ59654.1 268 5.7e-21 glycoside hydrolase family 1 [Phyllotreta striolata] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 P97265 169 7.0e-11 Cytosolic beta-glucosidase OS=Cavia porcellus GN=Gba3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.53690 BF_2 1428.89 26.14 2574 748995280 AJE75662.1 1445 4.6e-157 putative glycosyl hydrolase [Chrysomela lapponica] 827025214 LM524980.1 39 2.43161e-08 Strongyloides venezuelensis genome assembly S_venezuelensis_HH1, scaffold SVE_scaffold0000012 K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1051 9.3e-113 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF00232 Glycosyl hydrolase family 1 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.53693 BF_2 25.32 1.26 1126 17981717 NP_536731.1 416 4.2e-38 catalase [Drosophila melanogaster]>gi|1705622|sp|P17336.2|CATA_DROME RecName: Full=Catalase>gi|7690|emb|CAA36529.1| catalase [Drosophila melanogaster]>gi|451308|gb|AAC13738.1| catalase [Drosophila melanogaster]>gi|7293863|gb|AAF49228.1| catalase [Drosophila melanogaster]>gi|19527555|gb|AAL89892.1| RE33242p [Drosophila melanogaster]>gi|220957530|gb|ACL91308.1| Cat-PA [synthetic construct]>gi|220960164|gb|ACL92618.1| Cat-PA, partial [synthetic construct] 591389508 KJ160265.1 45 4.8329e-12 Anopheles stephensi catalase mRNA, partial cds K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P17336 416 1.7e-39 Catalase OS=Drosophila melanogaster GN=Cat PE=1 SV=2 PF00199 Catalase GO:0008292//GO:0055114//GO:0046486//GO:0006357//GO:0006568//GO:0006804//GO:0035206//GO:0007517//GO:0042967//GO:0006979//GO:0045676//GO:0042673//GO:0042542//GO:0006816//GO:0007274//GO:0008340//GO:0048813//GO:0016339//GO:0042676//GO:0015947//GO:0045944 acetylcholine biosynthetic process//oxidation-reduction process//glycerolipid metabolic process//regulation of transcription from RNA polymerase II promoter//tryptophan metabolic process//obsolete peroxidase reaction//regulation of hemocyte proliferation//muscle organ development//acyl-carrier-protein biosynthetic process//response to oxidative stress//regulation of R7 cell differentiation//regulation of retinal cone cell fate specification//response to hydrogen peroxide//calcium ion transport//neuromuscular synaptic transmission//determination of adult lifespan//dendrite morphogenesis//calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules//compound eye cone cell fate commitment//methane metabolic process//positive regulation of transcription from RNA polymerase II promoter GO:0008332//GO:0004096//GO:0020037//GO:0003705//GO:0004102 low voltage-gated calcium channel activity//catalase activity//heme binding//transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding//choline O-acetyltransferase activity GO:0005891//GO:0005777//GO:0005667//GO:0005634 voltage-gated calcium channel complex//peroxisome//transcription factor complex//nucleus KOG0047 Catalase Cluster-8309.53694 BF_2 52.74 0.40 5871 642915956 XP_008190826.1 1779 2.0e-195 PREDICTED: LOW QUALITY PROTEIN: protein kinase C, brain isozyme-like [Tribolium castaneum] 759058618 XM_011340249.1 327 4.45469e-168 PREDICTED: Cerapachys biroi protein kinase C, brain isozyme (LOC105280061), transcript variant X3, mRNA K02677 CPKC classical protein kinase C http://www.genome.jp/dbget-bin/www_bget?ko:K02677 P05130 1558 3.4e-171 Protein kinase C, brain isozyme OS=Drosophila melanogaster GN=Pkc53E PE=2 SV=2 PF07714//PF00628//PF07649//PF00069//PF09472//PF00130//PF00168//PF00433//PF06293//PF02150 Protein tyrosine kinase//PHD-finger//C1-like domain//Protein kinase domain//Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF)//Phorbol esters/diacylglycerol binding domain (C1 domain)//C2 domain//Protein kinase C terminal domain//Lipopolysaccharide kinase (Kdo/WaaP) family//RNA polymerases M/15 Kd subunit GO:0046656//GO:0006468//GO:0009069//GO:0055114//GO:0035556//GO:0016310//GO:0006144//GO:0006351//GO:0015948//GO:0006206 folic acid biosynthetic process//protein phosphorylation//serine family amino acid metabolic process//oxidation-reduction process//intracellular signal transduction//phosphorylation//purine nucleobase metabolic process//transcription, DNA-templated//methanogenesis//pyrimidine nucleobase metabolic process GO:0030269//GO:0003899//GO:0005524//GO:0004674//GO:0047134//GO:0005515//GO:0003677//GO:0004672//GO:0016773 tetrahydromethanopterin S-methyltransferase activity//DNA-directed RNA polymerase activity//ATP binding//protein serine/threonine kinase activity//protein-disulfide reductase activity//protein binding//DNA binding//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0005730//GO:0016020 nucleolus//membrane KOG0694 Serine/threonine protein kinase Cluster-8309.53696 BF_2 109.82 1.63 3104 546680133 ERL90474.1 1139 1.7e-121 hypothetical protein D910_07823 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P12883 223 1.1e-16 Myosin-7 OS=Homo sapiens GN=MYH7 PE=1 SV=5 PF06667 Phage shock protein B GO:0009271//GO:0006355 phage shock//regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.53700 BF_2 40.90 1.08 1864 332373120 AEE61701.1 190 1.1e-11 unknown [Dendroctonus ponderosae]>gi|546675000|gb|ERL86266.1| hypothetical protein D910_03675 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46108 147 4.5e-08 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53702 BF_2 274.56 2.69 4563 642925690 XP_008194671.1 3246 0.0e+00 PREDICTED: chloride channel protein 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 2318 2.0e-259 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654 Voltage gated chloride channel GO:0006821//GO:0055085 chloride transport//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0016020 membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.53705 BF_2 127.80 2.08 2852 270007206 EFA03654.1 2120 2.8e-235 hypothetical protein TcasGA2_TC013748 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 985 4.6e-105 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474//PF09036 Sodium:solute symporter family//Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0055085//GO:0009069//GO:0006468//GO:0006810//GO:0016310 signal transduction//transmembrane transport//serine family amino acid metabolic process//protein phosphorylation//transport//phosphorylation GO:0004674//GO:0005096//GO:0005215 protein serine/threonine kinase activity//GTPase activator activity//transporter activity GO:0016020 membrane -- -- Cluster-8309.53709 BF_2 25.00 0.38 3070 641664521 XP_008183038.1 488 5.2e-46 PREDICTED: uncharacterized protein LOC103309427 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5371 BF_2 7.00 0.67 723 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53712 BF_2 22.45 1.21 1065 501296187 BAN20955.1 397 6.4e-36 conserved hypothetical protein [Riptortus pedestris] -- -- -- -- -- -- -- -- -- Q9VBV3 253 1.3e-20 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53713 BF_2 1010.00 67.51 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53715 BF_2 11.38 0.47 1296 642919019 XP_008191698.1 398 6.0e-36 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53717 BF_2 72.50 0.67 4806 642926255 XP_008194846.1 2748 7.0e-308 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 5.78348e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1717 1.0e-189 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF00884//PF01663//PF00651//PF07646//PF01344 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase//BTB/POZ domain//Kelch motif//Kelch motif GO:0008152 metabolic process GO:0005515//GO:0003824//GO:0008484 protein binding//catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.53718 BF_2 66.40 0.60 4917 642926255 XP_008194846.1 2748 7.2e-308 PREDICTED: kelch-like protein 17 [Tribolium castaneum]>gi|270008515|gb|EFA04963.1| hypothetical protein TcasGA2_TC015037 [Tribolium castaneum] 195029940 XM_001987794.1 64 5.91806e-22 Drosophila grimshawi GH19736 (Dgri\GH19736), mRNA K10454 KLHL17 kelch-like protein 17 (actinfilin) http://www.genome.jp/dbget-bin/www_bget?ko:K10454 Q6TDP3 1717 1.1e-189 Kelch-like protein 17 OS=Mus musculus GN=Klhl17 PE=2 SV=1 PF07646//PF00651//PF00884//PF01344 Kelch motif//BTB/POZ domain//Sulfatase//Kelch motif GO:0008152 metabolic process GO:0008484//GO:0005515 sulfuric ester hydrolase activity//protein binding -- -- -- -- Cluster-8309.53719 BF_2 3.00 0.36 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53720 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00374 Nickel-dependent hydrogenase -- -- GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.53723 BF_2 6.42 1.40 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53724 BF_2 6.00 1.01 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53725 BF_2 9.25 0.47 1107 752880489 XP_011257814.1 272 2.1e-21 PREDICTED: putative nuclease HARBI1, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53726 BF_2 8.79 1.34 561 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53728 BF_2 3.58 1.15 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53730 BF_2 1.00 7.23 242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53734 BF_2 253.32 3.57 3254 728418700 AIY68378.1 1610 4.3e-176 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 665 6.7e-68 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 PF07859//PF00326//PF00067 alpha/beta hydrolase fold//Prolyl oligopeptidase family//Cytochrome P450 GO:0008152//GO:0055114//GO:0006508 metabolic process//oxidation-reduction process//proteolysis GO:0016787//GO:0016705//GO:0005506//GO:0008236//GO:0020037 hydrolase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//serine-type peptidase activity//heme binding -- -- -- -- Cluster-8309.53735 BF_2 31.41 0.57 2607 642914284 XP_008201621.1 1185 6.6e-127 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X1 [Tribolium castaneum] 642914285 XM_008203400.1 279 9.46753e-142 PREDICTED: Tribolium castaneum CCR4-NOT transcription complex subunit 6-like (LOC663221), transcript variant X2, mRNA K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 Q8K3P5 681 7.5e-70 CCR4-NOT transcription complex subunit 6 OS=Mus musculus GN=Cnot6 PE=1 SV=2 PF16093 Proteasome assembly chaperone 4 GO:0043248 proteasome assembly -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.53736 BF_2 32.00 3.62 657 758375894 AJO70199.1 611 6.0e-61 glyceraldehyde-3-phosphate-dehydrogenase [Cherax cainii] 306415940 GQ848032.1 654 0 Oryza sativa Japonica Group clone KCG225E10 glyceraldehyde-3-phosphate dehydrogenase mRNA, complete cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 Q6K5G8 769 1.2e-80 Glyceraldehyde-3-phosphate dehydrogenase 3, cytosolic OS=Oryza sativa subsp. japonica GN=GAPC3 PE=2 SV=1 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.53738 BF_2 117.08 1.73 3113 646722695 KDR23609.1 1885 5.3e-208 Periodic tryptophan protein 2-like protein [Zootermopsis nevadensis] -- -- -- -- -- K14558 PWP2, UTP1 periodic tryptophan protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14558 Q15269 1520 4.6e-167 Periodic tryptophan protein 2 homolog OS=Homo sapiens GN=PWP2 PE=1 SV=2 PF01764//PF08625//PF04053//PF02031//PF00400//PF00930//PF04192//PF09142//PF04617 Lipase (class 3)//Utp13 specific WD40 associated domain//Coatomer WD associated region//Streptomyces extracellular neutral proteinase (M7) family//WD domain, G-beta repeat//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Utp21 specific WD40 associated putative domain//tRNA Pseudouridine synthase II, C terminal//Hox9 activation region GO:0006508//GO:0009451//GO:0006629//GO:0006351//GO:0001522//GO:0006364//GO:0016192//GO:0006886 proteolysis//RNA modification//lipid metabolic process//transcription, DNA-templated//pseudouridine synthesis//rRNA processing//vesicle-mediated transport//intracellular protein transport GO:0005515//GO:0003723//GO:0008270//GO:0009982//GO:0005198//GO:0004222 protein binding//RNA binding//zinc ion binding//pseudouridine synthase activity//structural molecule activity//metalloendopeptidase activity GO:0030117//GO:0005576//GO:0005634//GO:0032040 membrane coat//extracellular region//nucleus//small-subunit processome KOG0291 WD40-repeat-containing subunit of the 18S rRNA processing complex Cluster-8309.53739 BF_2 12.85 0.47 1426 861588173 KMQ82585.1 435 3.4e-40 transposase-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02262//PF13683 CBL proto-oncogene N-terminal domain 1//Integrase core domain GO:0007166//GO:0015074//GO:0007165 cell surface receptor signaling pathway//DNA integration//signal transduction GO:0004871 signal transducer activity GO:0005634 nucleus -- -- Cluster-8309.53743 BF_2 276.17 7.41 1846 73921480 AAZ94270.1 1288 5.3e-139 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q9V4U7 941 3.8e-100 Probable cytochrome P450 6a14 OS=Drosophila melanogaster GN=Cyp6a14 PE=3 SV=2 PF00067//PF15681 Cytochrome P450//Lymphocyte activation family X GO:0055114//GO:0051249//GO:0006955 oxidation-reduction process//regulation of lymphocyte activation//immune response GO:0020037//GO:0005506//GO:0005488//GO:0016491//GO:0016705 heme binding//iron ion binding//binding//oxidoreductase activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.53745 BF_2 161.37 13.40 791 817011233 AKF11870.1 588 3.4e-58 putative juvenile hormone epoxide hydrolase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR6 492 1.9e-48 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.53747 BF_2 29.83 0.75 1946 642913383 XP_969242.3 997 3.1e-105 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 666 3.1e-68 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF00326//PF01738 Prolyl oligopeptidase family//Dienelactone hydrolase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2984 Predicted hydrolase Cluster-8309.53748 BF_2 17.16 0.41 2049 642913383 XP_969242.3 997 3.3e-105 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 666 3.2e-68 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF01738//PF00326 Dienelactone hydrolase family//Prolyl oligopeptidase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- KOG2984 Predicted hydrolase Cluster-8309.53749 BF_2 170.37 4.09 2028 642913383 XP_969242.3 997 3.2e-105 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 666 3.2e-68 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF00326//PF01738 Prolyl oligopeptidase family//Dienelactone hydrolase family GO:0006508 proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG2984 Predicted hydrolase Cluster-8309.53750 BF_2 1.89 1.35 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53757 BF_2 440.07 10.68 2011 167466181 NP_001107846.1 1363 1.2e-147 cytochrome P450 monooxigenase CYP4Q2 [Tribolium castaneum]>gi|270014305|gb|EFA10753.1| cytochrome P450-like protein [Tribolium castaneum] 815818840 XM_012375165.1 50 1.45262e-14 PREDICTED: Linepithema humile cytochrome P450 4C1-like (LOC105676933), mRNA K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1007 9.2e-108 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016491//GO:0005506//GO:0046872//GO:0020037//GO:0016705 oxidoreductase activity//iron ion binding//metal ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.53758 BF_2 45.40 0.43 4678 478250909 ENN71394.1 603 3.6e-59 hypothetical protein YQE_11898, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9QX47 328 1.2e-28 Protein SON OS=Mus musculus GN=Son PE=1 SV=2 PF05493//PF01585 ATP synthase subunit H//G-patch domain GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0003676//GO:0015078 nucleic acid binding//hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.5376 BF_2 3.00 0.41 591 270012482 EFA08930.1 244 2.0e-18 hypothetical protein TcasGA2_TC006637 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 P23622 156 1.3e-09 Sulfate permease 2 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cys-14 PE=2 SV=3 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.53760 BF_2 32.99 0.50 3057 478255213 ENN75442.1 276 2.0e-21 hypothetical protein YQE_07993, partial [Dendroctonus ponderosae] -- -- -- -- -- K00953 FLAD1 FAD synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00953 Q6ING7 194 2.6e-13 FAD synthase OS=Xenopus laevis GN=flad1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2644 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes Cluster-8309.53763 BF_2 48.40 1.22 1944 33113213 AAP94193.1 950 8.8e-100 cytochrome P450 monooxygenase [Tribolium castaneum] -- -- -- -- -- K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 P29981 717 3.8e-74 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- KOG0157 Cytochrome P450 CYP4/CYP19/CYP26 subfamilies Cluster-8309.53768 BF_2 193.43 2.35 3732 270003335 EEZ99782.1 1451 1.4e-157 hypothetical protein TcasGA2_TC002561 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ERD6 793 1.1e-82 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Mus musculus GN=Ralgps2 PE=1 SV=2 PF04636//PF05767//PF00617 PA26 p53-induced protein (sestrin)//Poxvirus virion envelope protein A14//RasGEF domain GO:1901031//GO:0007264//GO:0043087 regulation of response to reactive oxygen species//small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity GO:0019031//GO:0005634 viral envelope//nucleus KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.53772 BF_2 162.07 4.65 1745 642935508 XP_008198038.1 1304 7.0e-141 PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K17617 CTDNEP1, DULLARD, NEM1 CTD nuclear envelope phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17617 Q9VRG7 898 3.5e-95 CTD nuclear envelope phosphatase 1 homolog OS=Drosophila melanogaster GN=Dd PE=2 SV=1 PF06436//PF01621 Pneumovirus matrix protein 2 (M2)//Cell fusion glycoprotein K GO:0046782 regulation of viral transcription GO:0005198 structural molecule activity GO:0016020//GO:0019012 membrane//virion KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.53773 BF_2 132.50 3.66 1800 189241120 XP_973128.2 1177 3.9e-126 PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935513|ref|XP_008198040.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum]>gi|642935515|ref|XP_008198041.1| PREDICTED: CTD nuclear envelope phosphatase 1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K17617 CTDNEP1, DULLARD, NEM1 CTD nuclear envelope phosphatase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17617 Q9VRG7 961 1.8e-102 CTD nuclear envelope phosphatase 1 homolog OS=Drosophila melanogaster GN=Dd PE=2 SV=1 PF06436//PF01621 Pneumovirus matrix protein 2 (M2)//Cell fusion glycoprotein K GO:0046782 regulation of viral transcription GO:0005198 structural molecule activity GO:0016020//GO:0019012 membrane//virion KOG1605 TFIIF-interacting CTD phosphatase, including NLI-interacting factor (involved in RNA polymerase II regulation) Cluster-8309.53775 BF_2 19.00 1.44 841 226930 303 4.0e-25 ros1 gene 584458492 NG_033929.1 841 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 229 6.3e-18 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53776 BF_2 5.01 0.45 753 642912083 XP_008200795.1 224 5.2e-16 PREDICTED: phospholipase A2 inhibitor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53777 BF_2 5.00 0.78 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53778 BF_2 86.00 131.08 297 546683574 ERL93372.1 135 4.2e-06 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.53782 BF_2 8.87 0.41 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53783 BF_2 14.00 2.67 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53784 BF_2 58.67 1.30 2178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.53789 BF_2 372.89 5.01 3398 642924922 XP_008194098.1 1312 1.6e-141 PREDICTED: microtubule-associated protein futsch isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UMF0 209 5.3e-15 Cordon-bleu protein-like 1 OS=Mus musculus GN=Cobll1 PE=1 SV=2 PF02205//PF02196 WH2 motif//Raf-like Ras-binding domain GO:0007165 signal transduction GO:0003779//GO:0005057 actin binding//receptor signaling protein activity -- -- -- -- Cluster-8309.538 BF_2 6.00 0.53 761 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53803 BF_2 17.00 3.47 492 672032179 XP_008756614.1 641 1.5e-64 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform-like isoform X1 [Rattus norvegicus] 383087749 NG_012113.2 492 0 Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), RefSeqGene (LRG_310) on chromosome 3 K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 P32871 616 4.9e-63 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Bos taurus GN=PIK3CA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53805 BF_2 1.00 1.56 296 -- -- -- -- -- 33111956 AJ577263.1 60 5.34101e-21 Quercus robur partial mRNA for metallothionein-like protein (ORF1) -- -- -- -- O22319 146 9.2e-09 Metallothionein-like protein type 2 OS=Musa acuminata PE=3 SV=2 PF01439//PF02068 Metallothionein//Plant PEC family metallothionein -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.53807 BF_2 124.63 4.02 1584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53808 BF_2 123.80 5.85 1172 642929239 XP_008195748.1 325 1.6e-27 PREDICTED: uncharacterized protein LOC103313667 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01914//PF01284 MarC family integral membrane protein//Membrane-associating domain -- -- -- -- GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.53810 BF_2 161.20 2.45 3034 270007928 EFA04376.1 272 5.7e-21 hypothetical protein TcasGA2_TC014674 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07688//PF05273 KaiA domain//Poxvirus RNA polymerase 22 kDa subunit GO:0007623//GO:0006468//GO:0006144//GO:0019083//GO:0006351//GO:0006206 circadian rhythm//protein phosphorylation//purine nucleobase metabolic process//viral transcription//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.53818 BF_2 235.46 3.22 3343 642914462 XP_008201687.1 932 1.8e-97 PREDICTED: potassium channel subfamily K member 6-like isoform X1 [Tribolium castaneum]>gi|270001497|gb|EEZ97944.1| hypothetical protein TcasGA2_TC000334 [Tribolium castaneum] -- -- -- -- -- K04912 KCNK1 potassium channel subfamily K member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04912 Q5UE96 439 1.1e-41 Potassium channel subfamily K member 1 OS=Oryctolagus cuniculus GN=KCNK1 PE=2 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.53820 BF_2 20.68 0.39 2515 189236906 XP_001809986.1 1625 6.1e-178 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 781 1.8e-81 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.53822 BF_2 3.00 0.43 578 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53828 BF_2 5.34 0.32 975 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53830 BF_2 2.00 3.26 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53835 BF_2 89.71 2.17 2018 478255334 ENN75560.1 214 2.0e-14 hypothetical protein YQE_07903, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03595//PF06652 Voltage-dependent anion channel//Methuselah N-terminus GO:0006950//GO:0007186//GO:0055085 response to stress//G-protein coupled receptor signaling pathway//transmembrane transport GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.53836 BF_2 263.60 1.64 7003 642938167 XP_008190994.1 464 7.2e-43 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V818 148 1.3e-07 Probable G-protein coupled receptor Mth-like 3 OS=Drosophila melanogaster GN=mthl3 PE=1 SV=3 PF06963//PF00002//PF00001 Ferroportin1 (FPN1)//7 transmembrane receptor (Secretin family)//7 transmembrane receptor (rhodopsin family) GO:0006826//GO:0034755//GO:0007186 iron ion transport//iron ion transmembrane transport//G-protein coupled receptor signaling pathway GO:0005381//GO:0004930 iron ion transmembrane transporter activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.53840 BF_2 4.62 0.38 790 607304994 EZA45999.1 364 3.2e-32 NEDD4 family-interacting-like protein, partial [Microplitis demolitor] -- -- -- -- -- -- -- -- -- Q9NV92 186 5.7e-13 NEDD4 family-interacting protein 2 OS=Homo sapiens GN=NDFIP2 PE=1 SV=2 PF10176//PF03137 Protein of unknown function (DUF2370)//Organic Anion Transporter Polypeptide (OATP) family GO:0006810//GO:0007034//GO:0030001 transport//vacuolar transport//metal ion transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.53843 BF_2 79.42 0.54 6429 642929566 XP_008195887.1 2710 2.4e-303 PREDICTED: uncharacterized protein LOC664242 isoform X2 [Tribolium castaneum]>gi|270009578|gb|EFA06026.1| hypothetical protein TcasGA2_TC008856 [Tribolium castaneum] 817214723 XM_012428143.1 47 2.18484e-12 PREDICTED: Orussus abietinus GTP-binding protein Rit2 (LOC105701416), partial mRNA -- -- -- -- O88667 266 2.5e-21 GTP-binding protein RAD OS=Mus musculus GN=Rrad PE=1 SV=1 PF01868//PF03390//PF03193//PF01105//PF00071//PF00498//PF08477//PF00025 Domain of unknown function UPF0086//2-hydroxycarboxylate transporter family//Protein of unknown function, DUF258//emp24/gp25L/p24 family/GOLD//Ras family//FHA domain//Ras of Complex, Roc, domain of DAPkinase//ADP-ribosylation factor family GO:0006364//GO:0051252//GO:0008033//GO:0009987//GO:0006810//GO:0015711//GO:0007264//GO:0006379 rRNA processing//regulation of RNA metabolic process//tRNA processing//cellular process//transport//organic anion transport//small GTPase mediated signal transduction//mRNA cleavage GO:0008514//GO:0003924//GO:0004540//GO:0005525//GO:0003723//GO:0005515 organic anion transmembrane transporter activity//GTPase activity//ribonuclease activity//GTP binding//RNA binding//protein binding GO:0000172//GO:0016021//GO:0030677 ribonuclease MRP complex//integral component of membrane//ribonuclease P complex KOG0395 Ras-related GTPase Cluster-8309.53847 BF_2 77.38 1.42 2562 642927466 XP_008195284.1 1271 6.9e-137 PREDICTED: protein arginine N-methyltransferase 6 [Tribolium castaneum] -- -- -- -- -- K11435 PRMT2 protein arginine N-methyltransferase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11435 Q6NWG4 602 1.1e-60 Protein arginine N-methyltransferase 6 OS=Danio rerio GN=prmt6 PE=2 SV=2 PF01135//PF05175//PF08241//PF02527//PF03602//PF09243//PF05401//PF05185 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Methyltransferase domain//rRNA small subunit methyltransferase G//Conserved hypothetical protein 95//Mitochondrial small ribosomal subunit Rsm22//Nodulation protein S (NodS)//PRMT5 arginine-N-methyltransferase GO:0031167//GO:0006464//GO:0009312//GO:0000154//GO:0006396//GO:0006364//GO:0006412//GO:0008152//GO:0046500//GO:0009877//GO:0006479 rRNA methylation//cellular protein modification process//oligosaccharide biosynthetic process//rRNA modification//RNA processing//rRNA processing//translation//metabolic process//S-adenosylmethionine metabolic process//nodulation//protein methylation GO:0008168//GO:0008649//GO:0008757//GO:0004719 methyltransferase activity//rRNA methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0005737 cytoplasm KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.53848 BF_2 149.93 2.48 2812 642924862 XP_008194072.1 566 4.3e-55 PREDICTED: uncharacterized protein LOC656855 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53850 BF_2 114.01 2.23 2422 642928221 XP_008195493.1 1550 2.9e-169 PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928223|ref|XP_008195494.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928225|ref|XP_008195495.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum]>gi|642928227|ref|XP_008195496.1| PREDICTED: uncharacterized protein LOC103313600 [Tribolium castaneum] 642928222 XM_008197272.1 484 0 PREDICTED: Tribolium castaneum uncharacterized LOC103313600 (LOC103313600), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF11857 Domain of unknown function (DUF3377) -- -- GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.53857 BF_2 22.60 1.46 936 91077808 XP_970231.1 461 2.1e-43 PREDICTED: uncharacterized protein LOC658778 [Tribolium castaneum]>gi|270001488|gb|EEZ97935.1| hypothetical protein TcasGA2_TC000323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53858 BF_2 161.62 5.89 1436 91077808 XP_970231.1 636 1.7e-63 PREDICTED: uncharacterized protein LOC658778 [Tribolium castaneum]>gi|270001488|gb|EEZ97935.1| hypothetical protein TcasGA2_TC000323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08917 Transforming growth factor beta receptor 2 ectodomain GO:0016310//GO:0009069//GO:0006468//GO:0007178 phosphorylation//serine family amino acid metabolic process//protein phosphorylation//transmembrane receptor protein serine/threonine kinase signaling pathway GO:0005524//GO:0046872//GO:0005026 ATP binding//metal ion binding//transforming growth factor beta receptor activity, type II GO:0016020 membrane -- -- Cluster-8309.53866 BF_2 103.60 2.38 2109 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53868 BF_2 14.00 1.12 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53869 BF_2 46.36 1.16 1960 546686197 ERL95577.1 364 7.9e-32 hypothetical protein D910_12838 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.53874 BF_2 39.00 1.31 1530 270010054 EFA06502.1 567 1.8e-55 hypothetical protein TcasGA2_TC009401 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 264 1.0e-21 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.53880 BF_2 192.07 17.28 752 189234568 XP_001814929.1 178 1.1e-10 PREDICTED: uncharacterized protein LOC100142616 [Tribolium castaneum]>gi|270002080|gb|EEZ98527.1| hypothetical protein TcasGA2_TC001031 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.53884 BF_2 5.00 0.77 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04632 Fusaric acid resistance protein family GO:0006810 transport -- -- GO:0005886 plasma membrane -- -- Cluster-8309.53886 BF_2 245.06 5.35 2202 642933622 XP_008197499.1 2018 1.4e-223 PREDICTED: ubiquitin carboxyl-terminal hydrolase 7 isoform X2 [Tribolium castaneum]>gi|270011314|gb|EFA07762.1| hypothetical protein TcasGA2_TC005316 [Tribolium castaneum] -- -- -- -- -- K11838 USP7, UBP15 ubiquitin carboxyl-terminal hydrolase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K11838 Q93009 1264 1.6e-137 Ubiquitin carboxyl-terminal hydrolase 7 OS=Homo sapiens GN=USP7 PE=1 SV=2 -- -- GO:0016579//GO:0006511 protein deubiquitination//ubiquitin-dependent protein catabolic process GO:0004221 obsolete ubiquitin thiolesterase activity -- -- KOG1863 Ubiquitin carboxyl-terminal hydrolase Cluster-8309.53887 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53890 BF_2 39.15 3.09 817 751442604 XP_011195955.1 283 8.1e-23 PREDICTED: uncharacterized protein DDB_G0290301 isoform X1 [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q00690 165 1.6e-10 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53893 BF_2 20.44 1.85 750 642937577 XP_008199105.1 366 1.8e-32 PREDICTED: uncharacterized protein LOC103314533 [Tribolium castaneum]>gi|270001211|gb|EEZ97658.1| hypothetical protein TcasGA2_TC016202 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.53896 BF_2 168.54 1.60 4701 642933174 XP_008197288.1 1826 5.6e-201 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X1 [Tribolium castaneum]>gi|642933176|ref|XP_008197289.1| PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X1 [Tribolium castaneum] 430763429 JQ753065.1 49 1.23304e-13 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 Q92806 896 1.6e-94 G protein-activated inward rectifier potassium channel 3 OS=Homo sapiens GN=KCNJ9 PE=2 SV=2 PF01007//PF00520//PF10716 Inward rectifier potassium channel//Ion transport protein//NADH dehydrogenase transmembrane subunit GO:0055114//GO:0006811//GO:0006118//GO:0006813//GO:0055085 oxidation-reduction process//ion transport//obsolete electron transport//potassium ion transport//transmembrane transport GO:0016655//GO:0005216//GO:0005242 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//ion channel activity//inward rectifier potassium channel activity GO:0008076//GO:0016020//GO:0016021 voltage-gated potassium channel complex//membrane//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.53897 BF_2 2.00 0.41 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53900 BF_2 201.00 4.29 2248 642923944 XP_008193936.1 248 2.6e-18 PREDICTED: flexible cuticle protein 12-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P45589 222 1.1e-16 Flexible cuticle protein 12 OS=Hyalophora cecropia GN=CP12 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.53902 BF_2 342.37 17.05 1127 332374552 AEE62417.1 611 1.0e-60 unknown [Dendroctonus ponderosae]>gi|478249849|gb|ENN70356.1| hypothetical protein YQE_12864, partial [Dendroctonus ponderosae] -- -- -- -- -- K15382 SLC50A, SWEET solute carrier family 50 (sugar transporter) http://www.genome.jp/dbget-bin/www_bget?ko:K15382 Q7JVE7 217 2.1e-16 Sugar transporter SWEET1 OS=Drosophila melanogaster GN=slv PE=1 SV=1 PF01040//PF03083 UbiA prenyltransferase family//Sugar efflux transporter for intercellular exchange -- -- GO:0004659 prenyltransferase activity GO:0016021 integral component of membrane KOG1623 Multitransmembrane protein Cluster-8309.53906 BF_2 7.00 3.35 372 501595169 YP_007890615.1 510 1.7e-49 NADH dehydrogenase subunit 5 (mitochondrion) [Jakoba bahamiensis]>gi|462269319|gb|AGH24109.1| NADH dehydrogenase subunit 5 (mitochondrion) [Jakoba bahamiensis] 528540458 AP012528.1 372 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C K03883 ND5 NADH-ubiquinone oxidoreductase chain 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03883 Q37680 633 3.9e-65 NADH-ubiquinone oxidoreductase chain 5 OS=Triticum aestivum GN=ND5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4668 NADH dehydrogenase subunits 2, 5, and related proteins Cluster-8309.53914 BF_2 114.89 2.11 2562 765166496 XP_011492062.1 818 2.3e-84 PREDICTED: zinc finger protein 26-like isoform X3 [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 766 1.0e-79 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF13912//PF07776//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.53918 BF_2 14.00 0.44 1608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53919 BF_2 5.00 0.42 781 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53921 BF_2 33.26 1.08 1581 478256576 ENN76758.1 230 2.2e-16 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53922 BF_2 23.74 1.41 990 478256576 ENN76758.1 220 2.0e-15 hypothetical protein YQE_06599, partial [Dendroctonus ponderosae]>gi|546685228|gb|ERL94755.1| hypothetical protein D910_12029 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53923 BF_2 657.00 19.06 1729 642917912 XP_008191379.1 1034 1.4e-109 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q88168 523 1.0e-51 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.53924 BF_2 405.53 3.28 5455 642924788 XP_008194040.1 1633 1.6e-178 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 P07663 976 9.8e-104 Period circadian protein OS=Drosophila melanogaster GN=per PE=1 SV=2 PF00989//PF08447//PF00516//PF08926 PAS fold//PAS fold//Envelope glycoprotein GP120//Domain of unknown function (DUF1908) GO:0006355//GO:0016310//GO:0006468//GO:0009069 regulation of transcription, DNA-templated//phosphorylation//protein phosphorylation//serine family amino acid metabolic process GO:0004674//GO:0000287//GO:0005515//GO:0005524 protein serine/threonine kinase activity//magnesium ion binding//protein binding//ATP binding GO:0019031 viral envelope KOG3753 Circadian clock protein period Cluster-8309.53930 BF_2 205.98 1.35 6691 642935034 XP_008199914.1 265 8.1e-20 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 271 6.85411e-137 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- Q8IPM8 227 8.5e-17 Complexin OS=Drosophila melanogaster GN=cpx PE=2 SV=1 PF05550//PF02724//PF05835//PF03307//PF10186 Pestivirus Npro endopeptidase C53//CDC45-like protein//Synaphin protein//Adenovirus 15.3kD protein in E3 region//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006836//GO:0016032//GO:0019082//GO:0019049//GO:0006270//GO:0010508 neurotransmitter transport//viral process//viral protein processing//evasion or tolerance of host defenses by virus//DNA replication initiation//positive regulation of autophagy GO:0019905 syntaxin binding -- -- -- -- Cluster-8309.53931 BF_2 25.16 0.58 2100 642935034 XP_008199914.1 150 5.5e-07 PREDICTED: complexin isoform X1 [Tribolium castaneum]>gi|642935036|ref|XP_008199915.1| PREDICTED: complexin isoform X1 [Tribolium castaneum] 642935035 XM_008201693.1 201 1.74119e-98 PREDICTED: Tribolium castaneum complexin (LOC657060), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF02841//PF05835//PF04111//PF03938//PF10186 Guanylate-binding protein, C-terminal domain//Synaphin protein//Autophagy protein Apg6//Outer membrane protein (OmpH-like)//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0010508//GO:0006914//GO:0006836 positive regulation of autophagy//autophagy//neurotransmitter transport GO:0019905//GO:0003924//GO:0005525//GO:0051082 syntaxin binding//GTPase activity//GTP binding//unfolded protein binding -- -- -- -- Cluster-8309.53932 BF_2 215.82 2.95 3344 642919403 XP_008191855.1 1871 2.4e-206 PREDICTED: ubiquitin carboxyl-terminal hydrolase 46 [Tribolium castaneum] 642919402 XM_008193633.1 582 0 PREDICTED: Tribolium castaneum ubiquitin carboxyl-terminal hydrolase 46 (LOC663037), mRNA K11842 USP12_46 ubiquitin carboxyl-terminal hydrolase 12/46 http://www.genome.jp/dbget-bin/www_bget?ko:K11842 P62068 1430 1.4e-156 Ubiquitin carboxyl-terminal hydrolase 46 OS=Homo sapiens GN=USP46 PE=1 SV=1 PF00443//PF15499 Ubiquitin carboxyl-terminal hydrolase//Ubiquitin-specific peptidase-like, SUMO isopeptidase GO:0016579 protein deubiquitination GO:0070140//GO:0032183//GO:0036459 SUMO-specific isopeptidase activity//SUMO binding//ubiquitinyl hydrolase activity -- -- KOG1864 Ubiquitin-specific protease Cluster-8309.53933 BF_2 89.00 6.02 906 270013391 EFA09839.1 1524 1.1e-166 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 820865025 XM_012493602.1 84 8.06345e-34 PREDICTED: Apis florea uncharacterized LOC100872076 (LOC100872076), mRNA -- -- -- -- Q9UM47 208 1.8e-15 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53934 BF_2 44.00 4.48 698 270013391 EFA09839.1 1077 5.9e-115 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34576 159 6.8e-10 Transmembrane cell adhesion receptor mua-3 OS=Caenorhabditis elegans GN=mua-3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53935 BF_2 18.00 1.76 716 270013391 EFA09839.1 1026 5.0e-109 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 642935121 XM_008199675.1 95 4.84086e-40 PREDICTED: Tribolium castaneum uncharacterized LOC658528 (LOC658528), mRNA -- -- -- -- Q9UM47 202 7.2e-15 Neurogenic locus notch homolog protein 3 OS=Homo sapiens GN=NOTCH3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53936 BF_2 209.00 4.17 2386 270013391 EFA09839.1 3741 0.0e+00 hypothetical protein TcasGA2_TC011986 [Tribolium castaneum] 572300552 XM_006616302.1 145 2.67552e-67 PREDICTED: Apis dorsata uncharacterized LOC102671488 (LOC102671488), mRNA -- -- -- -- Q9QW30 335 9.1e-30 Neurogenic locus notch homolog protein 2 OS=Rattus norvegicus GN=Notch2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1217 Fibrillins and related proteins containing Ca2+-binding EGF-like domains Cluster-8309.53937 BF_2 1.00 8.36 238 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53938 BF_2 6.47 0.38 1006 795016637 XP_011858564.1 658 3.3e-66 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53940 BF_2 5.00 0.51 701 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53941 BF_2 165.95 1.20 6071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53942 BF_2 264.01 5.35 2350 332375488 AEE62885.1 1167 7.3e-125 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02089 CDK4 cyclin-dependent kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02089 Q91727 820 5.2e-86 Cyclin-dependent kinase 4 OS=Xenopus laevis GN=cdk4 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.53944 BF_2 29.87 0.60 2355 332375488 AEE62885.1 1167 7.3e-125 unknown [Dendroctonus ponderosae] -- -- -- -- -- K02089 CDK4 cyclin-dependent kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02089 Q91727 820 5.2e-86 Cyclin-dependent kinase 4 OS=Xenopus laevis GN=cdk4 PE=1 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0594 Protein kinase PCTAIRE and related kinases Cluster-8309.53946 BF_2 69.55 0.86 3653 91082339 XP_966549.1 5280 0.0e+00 PREDICTED: DNA-directed RNA polymerase III subunit RPC2 [Tribolium castaneum]>gi|270007487|gb|EFA03935.1| hypothetical protein TcasGA2_TC014075 [Tribolium castaneum] 719740584 XM_010211158.1 114 7.03351e-50 PREDICTED: Tinamus guttatus DNA-directed RNA polymerase III subunit RPC2 (LOC104564515), partial mRNA K03021 RPC2, POLR3B DNA-directed RNA polymerase III subunit RPC2 http://www.genome.jp/dbget-bin/www_bget?ko:K03021 P25167 4223 0.0e+00 DNA-directed RNA polymerase III subunit RPC2 OS=Drosophila melanogaster GN=RpIII128 PE=2 SV=2 PF04565//PF04566//PF00562//PF04563//PF04560//PF04567//PF04561 RNA polymerase Rpb2, domain 3//RNA polymerase Rpb2, domain 4//RNA polymerase Rpb2, domain 6//RNA polymerase beta subunit//RNA polymerase Rpb2, domain 7//RNA polymerase Rpb2, domain 5//RNA polymerase Rpb2, domain 2 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0032549 DNA-directed RNA polymerase activity//DNA binding//ribonucleoside binding GO:0005730 nucleolus KOG0215 RNA polymerase III, second largest subunit Cluster-8309.53948 BF_2 23.74 2.64 663 91094813 XP_970635.1 956 6.0e-101 PREDICTED: DNA-directed RNA polymerase II subunit RPB3 [Tribolium castaneum]>gi|270006567|gb|EFA03015.1| hypothetical protein TcasGA2_TC010438 [Tribolium castaneum] 751216889 XM_011163108.1 137 2.00501e-63 PREDICTED: Solenopsis invicta DNA-directed RNA polymerase II subunit RPB3 (LOC105196940), mRNA K03011 RPB3, POLR2C DNA-directed RNA polymerase II subunit RPB3 http://www.genome.jp/dbget-bin/www_bget?ko:K03011 P19387 724 2.0e-75 DNA-directed RNA polymerase II subunit RPB3 OS=Homo sapiens GN=POLR2C PE=1 SV=2 PF01193 RNA polymerase Rpb3/Rpb11 dimerisation domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046983 DNA-directed RNA polymerase activity//DNA binding//protein dimerization activity GO:0005730 nucleolus KOG1522 RNA polymerase II, subunit POLR2C/RPB3 Cluster-8309.53949 BF_2 8.00 1.06 604 817087870 XP_012266730.1 223 5.4e-16 PREDICTED: uncharacterized protein LOC105692236 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02421 Ferrous iron transport protein B GO:0015684 ferrous iron transport GO:0005525//GO:0015093 GTP binding//ferrous iron transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.53951 BF_2 7.46 0.49 927 861630394 KMQ90036.1 676 2.5e-68 hypothetical protein RF55_10255, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.53953 BF_2 197.00 24.32 626 -- -- -- -- -- 30725921 AC099043.6 612 0 Oryza sativa chromosome 3 BAC OSJNBa0079B15 genomic sequence, complete sequence -- -- -- -- A2XMB2 381 1.1e-35 10 kDa prolamin OS=Oryza sativa subsp. indica GN=OsI_013205 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.53957 BF_2 87.15 1.75 2372 815765156 XP_012221381.1 913 2.1e-95 PREDICTED: uncharacterized protein LOC105671622 [Linepithema humile] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00412//PF00751//PF00096 LIM domain//DM DNA binding domain//Zinc finger, C2H2 type GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270//GO:0043565 metal ion binding//zinc ion binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.53958 BF_2 132.86 2.25 2752 91092966 XP_966837.1 920 3.7e-96 PREDICTED: phosducin-like protein [Tribolium castaneum]>gi|270003166|gb|EEZ99613.1| hypothetical protein TcasGA2_TC002130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUR7 545 4.7e-54 Phosducin-like protein OS=Drosophila melanogaster GN=CG7650 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3171 Conserved phosducin-like protein Cluster-8309.53959 BF_2 84.16 1.01 3789 642915162 XP_008190500.1 1814 1.1e-199 PREDICTED: golgin IMH1-like [Tribolium castaneum]>gi|270003923|gb|EFA00371.1| hypothetical protein TcasGA2_TC003213 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P02562 152 2.4e-08 Myosin heavy chain, skeletal muscle (Fragments) OS=Oryctolagus cuniculus PE=1 SV=2 PF02135 TAZ zinc finger GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0008270//GO:0003712//GO:0004402 zinc ion binding//transcription cofactor activity//histone acetyltransferase activity GO:0000123//GO:0005634//GO:0005667 histone acetyltransferase complex//nucleus//transcription factor complex -- -- Cluster-8309.53962 BF_2 31.00 2.83 746 410911686 XP_003969321.1 913 6.5e-96 PREDICTED: 40S ribosomal protein S5 [Takifugu rubripes] 697448166 XM_009667215.1 256 1.60034e-129 PREDICTED: Struthio camelus australis ribosomal protein S5 (RPS5), mRNA K02989 RP-S5e, RPS5 small subunit ribosomal protein S5e http://www.genome.jp/dbget-bin/www_bget?ko:K02989 Q5E988 910 6.0e-97 40S ribosomal protein S5 OS=Bos taurus GN=RPS5 PE=2 SV=3 PF03969 AFG1-like ATPase -- -- GO:0005524 ATP binding -- -- KOG3291 Ribosomal protein S7 Cluster-8309.53963 BF_2 163.43 1.24 5792 270014503 EFA10951.1 4876 0.0e+00 hypothetical protein TcasGA2_TC004111 [Tribolium castaneum] 665818753 XM_008559999.1 137 1.83364e-62 PREDICTED: Microplitis demolitor putative DNA helicase Ino80 (LOC103578813), mRNA K11665 INO80, INOC1 DNA helicase INO80 http://www.genome.jp/dbget-bin/www_bget?ko:K11665 Q9VDY1 3025 0.0e+00 Putative DNA helicase Ino80 OS=Drosophila melanogaster GN=Ino80 PE=1 SV=2 PF00176//PF13892 SNF2 family N-terminal domain//DNA-binding domain -- -- GO:0003677//GO:0005524 DNA binding//ATP binding -- -- KOG0388 SNF2 family DNA-dependent ATPase Cluster-8309.53964 BF_2 212.23 4.59 2221 17646748 AAL41023.1 1674 1.1e-183 juvenile hormone esterase [Tenebrio molitor] -- -- -- -- -- K01063 JHE juvenile-hormone esterase http://www.genome.jp/dbget-bin/www_bget?ko:K01063 P35502 720 1.9e-74 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0006508//GO:0008152 proteolysis//metabolic process GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.53969 BF_2 4.00 0.38 726 546683481 ERL93287.1 721 1.2e-73 hypothetical protein D910_10583 [Dendroctonus ponderosae] 242012746 XM_002427044.1 86 4.94671e-35 Pediculus humanus corporis enhancer of zeste, ezh, putative, mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 623 1.1e-63 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG1079 Transcriptional repressor EZH1 Cluster-8309.53971 BF_2 77.19 1.91 1974 91088681 XP_974930.1 1028 8.0e-109 PREDICTED: synaptic vesicle membrane protein VAT-1 homolog [Tribolium castaneum]>gi|270012282|gb|EFA08730.1| hypothetical protein TcasGA2_TC006405 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8JFV8 482 6.8e-47 Synaptic vesicle membrane protein VAT-1 homolog OS=Danio rerio GN=vat1 PE=2 SV=1 PF00107//PF08240 Zinc-binding dehydrogenase//Alcohol dehydrogenase GroES-like domain GO:0055114 oxidation-reduction process GO:0005488 binding -- -- KOG1198 Zinc-binding oxidoreductase Cluster-8309.53975 BF_2 308.72 1.54 8677 642913944 XP_008201224.1 10793 0.0e+00 PREDICTED: leucine-rich repeat serine/threonine-protein kinase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TZM3 2932 0.0e+00 Leucine-rich repeat serine/threonine-protein kinase 1 OS=Caenorhabditis elegans GN=lrk-1 PE=1 SV=6 PF00071//PF07645//PF00023//PF00025//PF13855//PF13606//PF07714//PF08477//PF00069 Ras family//Calcium-binding EGF domain//Ankyrin repeat//ADP-ribosylation factor family//Leucine rich repeat//Ankyrin repeat//Protein tyrosine kinase//Ras of Complex, Roc, domain of DAPkinase//Protein kinase domain GO:0006468//GO:0007264 protein phosphorylation//small GTPase mediated signal transduction GO:0005509//GO:0005525//GO:0005524//GO:0004672//GO:0005515 calcium ion binding//GTP binding//ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.53978 BF_2 47.08 0.96 2337 641668003 XP_008184291.1 170 2.9e-09 PREDICTED: uncharacterized protein LOC103309773 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5398 BF_2 59.44 0.80 3399 91084005 XP_975287.1 2193 1.1e-243 PREDICTED: EH domain-containing protein 1-like [Tribolium castaneum] 642924768 XM_970194.2 329 1.98477e-169 PREDICTED: Tribolium castaneum EH domain-containing protein 1-like (LOC664181), mRNA K12483 EHD1 EH domain-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12483 Q641Z6 1806 3.5e-200 EH domain-containing protein 1 OS=Rattus norvegicus GN=Ehd1 PE=1 SV=1 PF13202//PF04670//PF03193//PF00036//PF12763//PF08477//PF13833//PF13405//PF13499//PF01926 EF hand//Gtr1/RagA G protein conserved region//Protein of unknown function, DUF258//EF hand//Cytoskeletal-regulatory complex EF hand//Ras of Complex, Roc, domain of DAPkinase//EF-hand domain pair//EF-hand domain//EF-hand domain pair//50S ribosome-binding GTPase GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005515//GO:0005509//GO:0005525 GTPase activity//protein binding//calcium ion binding//GTP binding -- -- -- -- Cluster-8309.53982 BF_2 205.71 1.67 5453 642929828 XP_008195992.1 980 8.2e-103 PREDICTED: ephrin-B1 [Tribolium castaneum]>gi|270010986|gb|EFA07434.1| hypothetical protein TcasGA2_TC008794 [Tribolium castaneum] 642929827 XM_008197770.1 229 1.2429e-113 PREDICTED: Tribolium castaneum ephrin-B1 (LOC664511), mRNA K05463 EFNB ephrin-B http://www.genome.jp/dbget-bin/www_bget?ko:K05463 O13097 208 1.1e-14 Ephrin-B1 OS=Xenopus laevis GN=efnb1 PE=1 SV=2 PF00812 Ephrin -- -- -- -- GO:0016020 membrane KOG3858 Ephrin, ligand for Eph receptor tyrosine kinase Cluster-8309.53983 BF_2 72.29 0.57 5610 642929828 XP_008195992.1 980 8.4e-103 PREDICTED: ephrin-B1 [Tribolium castaneum]>gi|270010986|gb|EFA07434.1| hypothetical protein TcasGA2_TC008794 [Tribolium castaneum] 642929827 XM_008197770.1 229 1.27892e-113 PREDICTED: Tribolium castaneum ephrin-B1 (LOC664511), mRNA K05463 EFNB ephrin-B http://www.genome.jp/dbget-bin/www_bget?ko:K05463 O13097 208 1.1e-14 Ephrin-B1 OS=Xenopus laevis GN=efnb1 PE=1 SV=2 PF00812 Ephrin -- -- -- -- GO:0016020 membrane KOG3858 Ephrin, ligand for Eph receptor tyrosine kinase Cluster-8309.53985 BF_2 90.76 1.11 3708 91091628 XP_970031.1 1001 2.0e-105 PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial [Tribolium castaneum] 780117224 XM_775688.3 40 9.77462e-09 PREDICTED: Strongylocentrotus purpuratus cathepsin L1 (LOC575275), mRNA K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 Q26636 881 6.9e-93 Cathepsin L OS=Sarcophaga peregrina PE=1 SV=1 PF04139//PF15163//PF02144//PF01180//PF03051//PF00112 Rad9//Meiosis-expressed//Repair protein Rad1/Rec1/Rad17//Dihydroorotate dehydrogenase//Peptidase C1-like family//Papain family cysteine protease GO:0000077//GO:0006508//GO:0055114//GO:0006281 DNA damage checkpoint//proteolysis//oxidation-reduction process//DNA repair GO:0008234//GO:0004197//GO:0016627 cysteine-type peptidase activity//cysteine-type endopeptidase activity//oxidoreductase activity, acting on the CH-CH group of donors GO:0005737//GO:0005634//GO:0030896 cytoplasm//nucleus//checkpoint clamp complex KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.53991 BF_2 270.71 31.64 645 270000727 EEZ97174.1 449 3.6e-42 hypothetical protein TcasGA2_TC004361 [Tribolium castaneum] 752865554 XM_011270924.1 89 9.38774e-37 PREDICTED: Camponotus floridanus RNA-binding protein 1-like (LOC105259161), transcript variant X11, mRNA K12896 SFRS7 splicing factor, arginine/serine-rich 7 http://www.genome.jp/dbget-bin/www_bget?ko:K12896 Q02427 409 6.5e-39 RNA-binding protein 1 OS=Drosophila melanogaster GN=Rbp1 PE=2 SV=3 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0107 Alternative splicing factor SRp20/9G8 (RRM superfamily) Cluster-8309.53994 BF_2 940.00 7.80 5330 91089913 XP_972686.1 1426 1.5e-154 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933954|ref|XP_008197580.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|642933957|ref|XP_008197581.1| PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270013662|gb|EFA10110.1| hypothetical protein TcasGA2_TC012289 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B0WC46 506 3.0e-49 Facilitated trehalose transporter Tret1 OS=Culex quinquefasciatus GN=Tret1 PE=3 SV=1 PF01306//PF00083//PF07690 LacY proton/sugar symporter//Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857 transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.53995 BF_2 15.00 0.36 2010 270007175 EFA03623.1 1786 1.0e-196 hypothetical protein TcasGA2_TC013716 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54004 BF_2 62.00 1.00 2874 270015894 EFA12342.1 2055 9.6e-228 hypothetical protein TcasGA2_TC001856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13912//PF03175//PF00096//PF00701 C2H2-type zinc finger//DNA polymerase type B, organellar and viral//Zinc finger, C2H2 type//Dihydrodipicolinate synthetase family GO:0006260//GO:0008152 DNA replication//metabolic process GO:0000166//GO:0008408//GO:0046872//GO:0016829//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//metal ion binding//lyase activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex -- -- Cluster-8309.54009 BF_2 159.00 3.62 2123 189234079 XP_001810604.1 738 3.7e-75 PREDICTED: pleckstrin homology domain-containing family J member 1 [Tribolium castaneum]>gi|270014493|gb|EFA10941.1| hypothetical protein TcasGA2_TC001772 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZCI3 239 1.1e-18 Pleckstrin homology domain-containing family J member 1 OS=Bos taurus GN=PLEKHJ1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54011 BF_2 67.00 0.69 4325 270004778 EFA01226.1 1108 9.3e-118 hypothetical protein TcasGA2_TC010553 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04323 854 1.1e-89 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF16588//PF00558//PF00098 C2H2 zinc-finger//Vpu protein//Zinc knuckle GO:0032801//GO:0019076//GO:0006812 receptor catabolic process//viral release from host cell//cation transport GO:0005261//GO:0008270//GO:0003676 cation channel activity//zinc ion binding//nucleic acid binding GO:0033644 host cell membrane KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.54012 BF_2 19.33 0.56 1721 270017072 EFA13518.1 639 9.0e-64 hypothetical protein TcasGA2_TC001491 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10394 466 4.2e-45 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54013 BF_2 304.00 6.05 2389 642939002 XP_008200112.1 644 3.3e-64 PREDICTED: uncharacterized protein LOC103314838 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54019 BF_2 14.00 0.54 1381 642926982 XP_008195090.1 172 1.0e-09 PREDICTED: glutathione synthetase-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K01920 gshB, GSS glutathione synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01920 -- -- -- -- PF03917 Eukaryotic glutathione synthase, ATP binding domain GO:0006750 glutathione biosynthetic process GO:0004363//GO:0005524 glutathione synthase activity//ATP binding -- -- -- -- Cluster-8309.54020 BF_2 172.36 5.01 1726 91085575 XP_968070.1 1854 1.2e-204 PREDICTED: glutathione synthetase-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K01920 gshB, GSS glutathione synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01920 P46413 996 1.5e-106 Glutathione synthetase OS=Rattus norvegicus GN=Gss PE=1 SV=1 PF03917//PF03199 Eukaryotic glutathione synthase, ATP binding domain//Eukaryotic glutathione synthase GO:0006750 glutathione biosynthetic process GO:0005524//GO:0004363 ATP binding//glutathione synthase activity -- -- KOG0021 Glutathione synthetase Cluster-8309.54023 BF_2 95.00 2.78 1716 642912127 XP_008200819.1 550 1.9e-53 PREDICTED: uncharacterized protein LOC100141711 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q7ZVG6 224 4.9e-17 E3 ubiquitin-protein ligase Siah1 OS=Danio rerio GN=siah1 PE=2 SV=2 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.54029 BF_2 204.84 3.82 2530 642939677 XP_008192358.1 254 5.8e-19 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103312719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF02892 Zinc finger, C2H2 type//BED zinc finger -- -- GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.54031 BF_2 2.00 0.40 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54035 BF_2 27.51 0.47 2716 328705425 XP_003242798.1 231 2.9e-16 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54038 BF_2 41.69 0.73 2668 270015371 EFA11819.1 231 2.8e-16 hypothetical protein TcasGA2_TC016421 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54040 BF_2 145.07 2.58 2643 642939677 XP_008192358.1 240 2.5e-17 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103312719 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF13465//PF00096//PF05320 BED zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677//GO:0046872 DNA-directed RNA polymerase activity//DNA binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.54044 BF_2 36.94 0.71 2469 189235509 XP_969871.2 1939 2.3e-214 PREDICTED: WD repeat-containing protein CG11141 [Tribolium castaneum]>gi|270003084|gb|EEZ99531.1| hypothetical protein TcasGA2_TC000113 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NLL1 721 1.6e-74 WD repeat-containing protein CG11141 OS=Drosophila melanogaster GN=CG11141 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3621 WD40 repeat-containing protein Cluster-8309.54048 BF_2 36.00 2.08 1011 642930259 XP_008196320.1 587 5.6e-58 PREDICTED: uncharacterized protein LOC103313831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.54049 BF_2 57.34 0.95 2816 91076832 XP_974636.1 2505 6.2e-280 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] -- -- -- -- -- K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 296 3.6e-25 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 -- -- -- -- GO:0000166//GO:0004672 nucleotide binding//protein kinase activity -- -- -- -- Cluster-8309.54050 BF_2 123.25 2.11 2726 260799997 XP_002594923.1 439 2.2e-40 hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae]>gi|229280161|gb|EEN50934.1| hypothetical protein BRAFLDRAFT_72305 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- O62836 323 2.6e-28 Zinc finger X-chromosomal protein OS=Bos taurus GN=ZFX PE=2 SV=2 PF02150//PF13465//PF00096//PF07649 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0047134//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//protein-disulfide reductase activity//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.54053 BF_2 178.80 3.98 2168 91090216 XP_968004.1 1600 4.2e-175 PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|642934767|ref|XP_008197799.1| PREDICTED: protein-tyrosine sulfotransferase [Tribolium castaneum]>gi|270013461|gb|EFA09909.1| hypothetical protein TcasGA2_TC012060 [Tribolium castaneum] 642934766 XM_008199577.1 407 0 PREDICTED: Tribolium castaneum protein-tyrosine sulfotransferase (LOC656373), transcript variant X2, mRNA K01021 TPST protein-tyrosine sulfotransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01021 Q9VYB7 1337 5.4e-146 Protein-tyrosine sulfotransferase OS=Drosophila melanogaster GN=Tango13 PE=2 SV=2 PF00685 Sulfotransferase domain GO:0006478 peptidyl-tyrosine sulfation GO:0008476//GO:0008146 protein-tyrosine sulfotransferase activity//sulfotransferase activity -- -- KOG3988 Protein-tyrosine sulfotransferase TPST1/TPST2 Cluster-8309.54054 BF_2 31.10 1.67 1065 642940144 XP_008200104.1 770 3.6e-79 PREDICTED: vacuolar protein sorting-associated protein 16 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9L7 341 8.2e-31 Vacuolar protein sorting-associated protein 16 homolog OS=Bos taurus GN=VPS16 PE=2 SV=1 PF04840 Vps16, C-terminal region GO:0006886 intracellular protein transport -- -- GO:0005737 cytoplasm KOG2280 Vacuolar assembly/sorting protein VPS16 Cluster-8309.54056 BF_2 110.64 2.51 2131 478259957 ENN79759.1 861 2.0e-89 hypothetical protein YQE_03815, partial [Dendroctonus ponderosae]>gi|546681505|gb|ERL91582.1| hypothetical protein D910_08912 [Dendroctonus ponderosae] -- -- -- -- -- K05617 SLC1A6, EAAT4 solute carrier family 1 (high affinity aspartate/glutamate transporter), member 6 http://www.genome.jp/dbget-bin/www_bget?ko:K05617 P48664 635 1.3e-64 Excitatory amino acid transporter 4 OS=Homo sapiens GN=SLC1A6 PE=2 SV=1 PF00375//PF07810 Sodium:dicarboxylate symporter family//TMC domain GO:0006812//GO:0006835//GO:0006820 cation transport//dicarboxylic acid transport//anion transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.54058 BF_2 203.78 7.45 1431 270016600 EFA13046.1 217 6.4e-15 hypothetical protein TcasGA2_TC010748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5406 BF_2 8.00 0.39 1137 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54060 BF_2 9.00 1.36 564 -- -- -- -- -- 720072043 XM_010279938.1 78 1.06087e-30 PREDICTED: Nelumbo nucifera uncharacterized protein At4g22758 (LOC104612504), mRNA -- -- -- -- Q56XJ7 162 2.5e-10 Uncharacterized protein At4g22758 OS=Arabidopsis thaliana GN=At4g22758 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54062 BF_2 3.00 0.82 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54064 BF_2 8.50 0.43 1117 642928075 XP_008200145.1 322 3.3e-27 PREDICTED: cuticle protein 8-like [Tribolium castaneum]>gi|270010867|gb|EFA07315.1| hypothetical protein TcasGA2_TC015908 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 267 3.3e-22 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.54067 BF_2 202.98 4.68 2103 189238819 XP_967914.2 2083 4.0e-231 PREDICTED: N6-adenosine-methyltransferase 70 kDa subunit [Tribolium castaneum]>gi|270009967|gb|EFA06415.1| hypothetical protein TcasGA2_TC009294 [Tribolium castaneum] 719791100 XM_010225608.1 200 6.27154e-98 PREDICTED: Tinamus guttatus methyltransferase like 3 (METTL3), partial mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q86U44 1439 7.7e-158 N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 PF05063//PF07700//PF03121 MT-A70//Haem-NO-binding//Herpesviridae UL52/UL70 DNA primase GO:0006396//GO:0009451//GO:0006269//GO:0006260//GO:0006139//GO:0001510//GO:0006351 RNA processing//RNA modification//DNA replication, synthesis of RNA primer//DNA replication//nucleobase-containing compound metabolic process//RNA methylation//transcription, DNA-templated GO:0020037//GO:0008168//GO:0003896//GO:0016422 heme binding//methyltransferase activity//DNA primase activity//mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity GO:0005730//GO:0005657//GO:0005634 nucleolus//replication fork//nucleus KOG2098 Predicted N6-adenine RNA methylase Cluster-8309.54068 BF_2 13.02 0.33 1957 189238819 XP_967914.2 2069 1.5e-229 PREDICTED: N6-adenosine-methyltransferase 70 kDa subunit [Tribolium castaneum]>gi|270009967|gb|EFA06415.1| hypothetical protein TcasGA2_TC009294 [Tribolium castaneum] 719791100 XM_010225608.1 200 5.82877e-98 PREDICTED: Tinamus guttatus methyltransferase like 3 (METTL3), partial mRNA K05925 METTL3_14 mRNA (2'-O-methyladenosine-N6-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K05925 Q86U44 1439 7.2e-158 N6-adenosine-methyltransferase 70 kDa subunit OS=Homo sapiens GN=METTL3 PE=1 SV=2 PF03121//PF07700//PF05063 Herpesviridae UL52/UL70 DNA primase//Haem-NO-binding//MT-A70 GO:0006260//GO:0006269//GO:0009451//GO:0006396//GO:0001510//GO:0006351//GO:0006139 DNA replication//DNA replication, synthesis of RNA primer//RNA modification//RNA processing//RNA methylation//transcription, DNA-templated//nucleobase-containing compound metabolic process GO:0008168//GO:0020037//GO:0003896//GO:0016422 methyltransferase activity//heme binding//DNA primase activity//mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity GO:0005730//GO:0005657//GO:0005634 nucleolus//replication fork//nucleus KOG2098 Predicted N6-adenine RNA methylase Cluster-8309.54075 BF_2 25.00 0.82 1565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54076 BF_2 228.25 5.57 2002 546683411 ERL93227.1 1986 6.7e-220 hypothetical protein D910_10523 [Dendroctonus ponderosae] 830067296 XM_004687410.2 167 1.31895e-79 PREDICTED: Condylura cristata serine/threonine kinase 4 (STK4), mRNA K04412 STK3, MST2 serine/threonine kinase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04412 Q7ZUQ3 1336 6.5e-146 Serine/threonine-protein kinase 3 OS=Danio rerio GN=stk3 PE=2 SV=1 PF00069//PF07714//PF11629 Protein kinase domain//Protein tyrosine kinase//C terminal SARAH domain of Mst1 GO:0006468//GO:0009069//GO:0016310 protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0004674//GO:0004672 ATP binding//protein serine/threonine kinase activity//protein kinase activity -- -- KOG0574 STE20-like serine/threonine kinase MST Cluster-8309.54081 BF_2 133.13 1.33 4461 270008889 EFA05337.1 1352 4.9e-146 hypothetical protein TcasGA2_TC015501 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MKK4 678 2.9e-69 Facilitated trehalose transporter Tret1-2 homolog OS=Drosophila melanogaster GN=Tret1-2 PE=2 SV=1 PF10483//PF00083//PF08029//PF07690//PF05493//PF02487 Elongator subunit Iki1//Sugar (and other) transporter//HisG, C-terminal domain//Major Facilitator Superfamily//ATP synthase subunit H//CLN3 protein GO:0055085//GO:0015991//GO:0006547//GO:0000105//GO:0015992 transmembrane transport//ATP hydrolysis coupled proton transport//histidine metabolic process//histidine biosynthetic process//proton transport GO:0022857//GO:0003879//GO:0015078//GO:0000287 transmembrane transporter activity//ATP phosphoribosyltransferase activity//hydrogen ion transmembrane transporter activity//magnesium ion binding GO:0016021//GO:0016020//GO:0033179//GO:0005737//GO:0033588 integral component of membrane//membrane//proton-transporting V-type ATPase, V0 domain//cytoplasm//Elongator holoenzyme complex KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.54087 BF_2 170.23 3.59 2270 642937299 XP_008198776.1 862 1.6e-89 PREDICTED: DNA excision repair protein ERCC-1 [Tribolium castaneum] -- -- -- -- -- K10849 ERCC1 DNA excision repair protein ERCC-1 http://www.genome.jp/dbget-bin/www_bget?ko:K10849 P07992 621 5.9e-63 DNA excision repair protein ERCC-1 OS=Homo sapiens GN=ERCC1 PE=1 SV=1 PF01367//PF00633//PF01296//PF10391//PF07690 5'-3' exonuclease, C-terminal SAM fold//Helix-hairpin-helix motif//Galanin//Fingers domain of DNA polymerase lambda//Major Facilitator Superfamily GO:0007165//GO:0055085 signal transduction//transmembrane transport GO:0003824//GO:0003677//GO:0005179//GO:0034061 catalytic activity//DNA binding//hormone activity//DNA polymerase activity GO:0016021//GO:0005634//GO:0005576 integral component of membrane//nucleus//extracellular region KOG2841 Structure-specific endonuclease ERCC1-XPF, ERCC1 component Cluster-8309.54089 BF_2 9.00 0.61 903 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54092 BF_2 21.96 0.34 3007 642910866 XP_001813884.2 483 1.9e-45 PREDICTED: histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1 [Tribolium castaneum] 642910867 XM_008195218.1 77 2.13753e-29 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase, H3 lysine-79 specific (LOC660658), transcript variant X2, mRNA K11427 DOT1L, DOT1 histone-lysine N-methyltransferase, H3 lysine-79 specific http://www.genome.jp/dbget-bin/www_bget?ko:K11427 -- -- -- -- PF05191 Adenylate kinase, active site lid GO:0006144//GO:0046034 purine nucleobase metabolic process//ATP metabolic process GO:0004017 adenylate kinase activity -- -- -- -- Cluster-8309.54093 BF_2 8.00 0.56 884 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54094 BF_2 8.00 0.46 1018 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54095 BF_2 2.00 1.18 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54098 BF_2 50.50 1.57 1630 328705425 XP_003242798.1 264 2.6e-20 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF13639//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Ring finger domain//BED zinc finger -- -- GO:0008270//GO:0003677//GO:0005515//GO:0046872 zinc ion binding//DNA binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.54099 BF_2 9.68 0.46 1166 328705425 XP_003242798.1 264 1.8e-20 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF13639//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//Ring finger domain//BED zinc finger -- -- GO:0003677//GO:0008270//GO:0005515//GO:0046872 DNA binding//zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.5410 BF_2 7.00 0.43 961 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54101 BF_2 190.37 4.41 2091 91091144 XP_970545.1 1198 1.6e-128 PREDICTED: uncharacterized protein LOC659120 [Tribolium castaneum]>gi|270014092|gb|EFA10540.1| hypothetical protein TcasGA2_TC012795 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- -- -- Cluster-8309.54103 BF_2 25.47 0.38 3060 642932510 XP_008197143.1 2229 6.8e-248 PREDICTED: chromosome transmission fidelity protein 18 homolog [Tribolium castaneum] -- -- -- -- -- K11269 CTF18, CHL12 chromosome transmission fidelity protein 18 http://www.genome.jp/dbget-bin/www_bget?ko:K11269 Q6NU40 1245 3.5e-135 Chromosome transmission fidelity protein 18 homolog OS=Xenopus laevis GN=chtf18 PE=2 SV=1 PF00004//PF07724//PF01695//PF07728//PF05496//PF08519//PF00910//PF00931//PF00005//PF03266//PF03193//PF06414 ATPase family associated with various cellular activities (AAA)//AAA domain (Cdc48 subfamily)//IstB-like ATP binding protein//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Replication factor RFC1 C terminal domain//RNA helicase//NB-ARC domain//ABC transporter//NTPase//Protein of unknown function, DUF258//Zeta toxin GO:0006310//GO:0006260//GO:0006281 DNA recombination//DNA replication//DNA repair GO:0005525//GO:0003724//GO:0009378//GO:0003723//GO:0043531//GO:0003689//GO:0016887//GO:0016301//GO:0005524//GO:0098519//GO:0003924 GTP binding//RNA helicase activity//four-way junction helicase activity//RNA binding//ADP binding//DNA clamp loader activity//ATPase activity//kinase activity//ATP binding//nucleotide phosphatase activity, acting on free nucleotides//GTPase activity GO:0005657//GO:0009379//GO:0005663//GO:0042575 replication fork//Holliday junction helicase complex//DNA replication factor C complex//DNA polymerase complex KOG1969 DNA replication checkpoint protein CHL12/CTF18 Cluster-8309.54106 BF_2 135.14 2.31 2738 91092966 XP_966837.1 920 3.7e-96 PREDICTED: phosducin-like protein [Tribolium castaneum]>gi|270003166|gb|EEZ99613.1| hypothetical protein TcasGA2_TC002130 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUR7 545 4.7e-54 Phosducin-like protein OS=Drosophila melanogaster GN=CG7650 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3171 Conserved phosducin-like protein Cluster-8309.54107 BF_2 204.20 2.49 3724 642932262 XP_008197037.1 3943 0.0e+00 PREDICTED: exosome complex exonuclease RRP44 [Tribolium castaneum]>gi|270012315|gb|EFA08763.1| hypothetical protein TcasGA2_TC006450 [Tribolium castaneum] 642932261 XM_008198815.1 549 0 PREDICTED: Tribolium castaneum exosome complex exonuclease RRP44 (LOC655788), mRNA K12585 DIS3, RRP44 exosome complex exonuclease DIS3/RRP44 http://www.genome.jp/dbget-bin/www_bget?ko:K12585 Q9Y2L1 2571 7.5e-289 Exosome complex exonuclease RRP44 OS=Homo sapiens GN=DIS3 PE=1 SV=2 -- -- GO:0051252 regulation of RNA metabolic process GO:0004540//GO:0003723 ribonuclease activity//RNA binding -- -- KOG2102 Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 Cluster-8309.54114 BF_2 207.03 5.75 1794 642914168 XP_972661.2 528 6.9e-51 PREDICTED: crossover junction endonuclease EME1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10882 EME1, MMS4 crossover junction endonuclease EME1 http://www.genome.jp/dbget-bin/www_bget?ko:K10882 Q96AY2 224 5.1e-17 Crossover junction endonuclease EME1 OS=Homo sapiens GN=EME1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54116 BF_2 84.87 1.40 2818 642910982 XP_008193494.1 1168 6.7e-125 PREDICTED: uncharacterized protein LOC662081 isoform X1 [Tribolium castaneum] 642910981 XM_008195272.1 151 1.46216e-70 PREDICTED: Tribolium castaneum uncharacterized LOC662081 (LOC662081), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF01607//PF15221 Chitin binding Peritrophin-A domain//Lens epithelial cell protein LEP503 GO:0006030//GO:0007275 chitin metabolic process//multicellular organismal development GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.5412 BF_2 5.00 0.48 720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54120 BF_2 23.87 1.80 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01244 Membrane dipeptidase (Peptidase family M19) GO:0006508 proteolysis GO:0016805 dipeptidase activity -- -- -- -- Cluster-8309.54121 BF_2 5.00 2.47 369 817307477 XP_012324300.1 273 5.3e-22 PREDICTED: discoidin domain-containing receptor 2 isoform X1 [Aotus nancymaae] 282721095 NG_016290.1 369 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 273 2.2e-23 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54124 BF_2 13.17 0.31 2076 675379531 KFM72433.1 325 2.8e-27 Zinc finger protein 99, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UK10 284 6.5e-24 Zinc finger protein 225 OS=Homo sapiens GN=ZNF225 PE=2 SV=2 PF00412//PF13912//PF07776//PF00096//PF13465//PF07975 LIM domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain//TFIIH C1-like domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.54126 BF_2 100.58 3.04 1671 766936334 XP_011500571.1 1518 1.0e-165 PREDICTED: mitogen-activated protein kinase kinase kinase kinase 5 [Ceratosolen solmsi marchali] 820866238 XM_012494102.1 302 9.86551e-155 PREDICTED: Apis florea mitogen-activated protein kinase kinase kinase kinase 5 (LOC100864577), transcript variant X9, mRNA K08833 MAP4K5, KHS1 mitogen-activated protein kinase kinase kinase kinase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08833 Q8IVH8 1293 5.2e-141 Mitogen-activated protein kinase kinase kinase kinase 3 OS=Homo sapiens GN=MAP4K3 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0576 Mitogen-activated protein kinase kinase kinase kinase (MAP4K), germinal center kinase family Cluster-8309.54127 BF_2 39.95 0.35 5128 478254223 ENN74488.1 523 7.5e-50 hypothetical protein YQE_08933, partial [Dendroctonus ponderosae]>gi|546675245|gb|ERL86481.1| hypothetical protein D910_03886 [Dendroctonus ponderosae] -- -- -- -- -- K13868 SLC7A9, BAT1 solute carrier family 7 (L-type amino acid transporter), member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K13868 Q9QXA6 361 1.9e-32 b(0,+)-type amino acid transporter 1 OS=Mus musculus GN=Slc7a9 PE=1 SV=1 PF01194//PF13520//PF02203//PF00324 RNA polymerases N / 8 kDa subunit//Amino acid permease//Tar ligand binding domain homologue//Amino acid permease GO:0006144//GO:0006810//GO:0006865//GO:0006351//GO:0007165//GO:0055085//GO:0006935//GO:0006206//GO:0003333 purine nucleobase metabolic process//transport//amino acid transport//transcription, DNA-templated//signal transduction//transmembrane transport//chemotaxis//pyrimidine nucleobase metabolic process//amino acid transmembrane transport GO:0003899//GO:0004888//GO:0003677//GO:0015171 DNA-directed RNA polymerase activity//transmembrane signaling receptor activity//DNA binding//amino acid transmembrane transporter activity GO:0005730//GO:0016020 nucleolus//membrane -- -- Cluster-8309.54128 BF_2 36.60 1.36 1412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01956 Integral membrane protein DUF106 -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.54132 BF_2 82.00 24.59 426 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54137 BF_2 4.00 0.46 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887 Procyclic acidic repetitive protein (PARP) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.54138 BF_2 3.00 0.31 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54144 BF_2 29.11 1.76 980 357605860 EHJ64807.1 370 7.9e-33 translation initiation factor 1a [Danaus plexippus] -- -- -- -- -- K15025 EIF1AD probable RNA-binding protein EIF1AD http://www.genome.jp/dbget-bin/www_bget?ko:K15025 Q8IQ13 306 8.6e-27 Probable RNA-binding protein EIF1AD OS=Drosophila melanogaster GN=CG31957 PE=2 SV=1 PF01176 Translation initiation factor 1A / IF-1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743 RNA binding//translation initiation factor activity GO:0005840 ribosome -- -- Cluster-8309.54150 BF_2 318.00 7.38 2090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54152 BF_2 34.89 0.32 4808 641658099 XP_008180596.1 1075 6.9e-114 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 967 9.5e-103 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF00096//PF13465//PF00400//PF16622//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//WD domain, G-beta repeat//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.54153 BF_2 26.60 0.31 3865 642934848 XP_008197836.1 1118 5.8e-119 PREDICTED: CAP-Gly domain-containing linker protein 1 [Tribolium castaneum] 642934847 XM_008199614.1 174 3.2968e-83 PREDICTED: Tribolium castaneum CAP-Gly domain-containing linker protein 1 (LOC659034), mRNA K10423 CLIP3_4 CAP-Gly domain-containing linker protein 3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K10423 B9EHT4 189 1.3e-12 CAP-Gly domain-containing linker protein 3 OS=Mus musculus GN=Clip3 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4568 Cytoskeleton-associated protein and related proteins Cluster-8309.54154 BF_2 11.38 1.34 643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54155 BF_2 698.20 60.62 769 546679670 ERL90097.1 447 7.3e-42 hypothetical protein D910_07451 [Dendroctonus ponderosae] 158285680 XM_001687879.1 55 8.98055e-18 Anopheles gambiae str. PEST AGAP007421-PA (AgaP_AGAP007421) mRNA, complete cds K18334 fucD L-fuconate dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K18334 Q5RAT4 267 2.2e-22 Mitochondrial enolase superfamily member 1 OS=Pongo abelii GN=ENOSF1 PE=2 SV=1 PF04421 Mss4 protein GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.54156 BF_2 148.00 1.39 4744 642927984 XP_008195472.1 755 8.7e-77 PREDICTED: uncharacterized protein LOC662997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01805//PF00001 Surp module//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0006396 G-protein coupled receptor signaling pathway//RNA processing GO:0003723//GO:0004930 RNA binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.54157 BF_2 189.30 3.71 2419 242018392 XP_002429661.1 645 2.5e-64 krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis]>gi|212514646|gb|EEB16923.1| krueppel c2h2-type zinc finger protein, putative [Pediculus humanus corporis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 529 2.9e-52 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF13465//PF00096 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.54158 BF_2 180.00 3.83 2253 642913102 XP_008201393.1 1765 3.2e-194 PREDICTED: PCI domain-containing protein 2 [Tribolium castaneum]>gi|642913104|ref|XP_001816040.2| PREDICTED: PCI domain-containing protein 2 [Tribolium castaneum]>gi|270001938|gb|EEZ98385.1| hypothetical protein TcasGA2_TC000849 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BFV2 1195 1.6e-129 PCI domain-containing protein 2 OS=Mus musculus GN=Pcid2 PE=2 SV=1 PF01399 PCI domain -- -- GO:0005515 protein binding -- -- KOG2688 Transcription-associated recombination protein - Thp1p Cluster-8309.54172 BF_2 181.33 2.14 3832 642919536 XP_008191915.1 155 2.6e-07 PREDICTED: uncharacterized protein LOC103312626 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54176 BF_2 37.12 0.47 3587 478252683 ENN73079.1 193 9.7e-12 hypothetical protein YQE_10283, partial [Dendroctonus ponderosae]>gi|546682842|gb|ERL92731.1| hypothetical protein D910_10041 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54179 BF_2 88.00 1.56 2650 209837708 BAG75149.1 148 1.2e-06 fusion protein EML4-ALK variant 5 splicing isoform b [Homo sapiens] 221554531 NG_009445.1 2641 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54180 BF_2 227.00 1.05 9292 219522040 NP_001137201.1 1569 7.0e-171 mex-3 protein [Tribolium castaneum]>gi|218464687|emb|CAM28380.2| KH domain protein [Tribolium castaneum] 219522039 NM_001143729.1 449 0 Tribolium castaneum mex-3 protein (Mex-3), mRNA >gnl|BL_ORD_ID|6206389 Tribolium castaneum mRNA for KH domain protein (mex-3 gene) K15686 MEX3, RKHD RNA-binding protein MEX3 http://www.genome.jp/dbget-bin/www_bget?ko:K15686 Q6ZN04 655 2.8e-66 RNA-binding protein MEX3B OS=Homo sapiens GN=MEX3B PE=1 SV=1 PF03854//PF00013//PF07650//PF13639//PF12678//PF14634//PF13014//PF00097 P-11 zinc finger//KH domain//KH domain//Ring finger domain//RING-H2 zinc finger//zinc-RING finger domain//KH domain//Zinc finger, C3HC4 type (RING finger) -- -- GO:0008270//GO:0003723//GO:0005515//GO:0046872 zinc ion binding//RNA binding//protein binding//metal ion binding -- -- KOG2113 Predicted RNA binding protein, contains KH domain Cluster-8309.54182 BF_2 106.62 0.76 6157 642935465 XP_008198021.1 297 1.5e-23 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X2 [Tribolium castaneum] 642935470 XM_967302.3 113 4.28098e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- -- -- -- -- PF01328 Peroxidase, family 2 GO:0006804//GO:0006979 obsolete peroxidase reaction//response to oxidative stress GO:0004601 peroxidase activity -- -- -- -- Cluster-8309.54183 BF_2 466.59 2.00 10047 642935463 XP_008198020.1 3170 0.0e+00 PREDICTED: constitutive coactivator of PPAR-gamma-like protein 1 isoform X1 [Tribolium castaneum] 642935470 XM_967302.3 113 6.99872e-49 PREDICTED: Tribolium castaneum constitutive coactivator of PPAR-gamma-like protein 1 (LOC661120), transcript variant X5, mRNA -- -- -- -- Q6A0A9 763 9.0e-79 Constitutive coactivator of PPAR-gamma-like protein 1 OS=Mus musculus GN=FAM120A PE=1 SV=2 PF07690//PF00083//PF01328 Major Facilitator Superfamily//Sugar (and other) transporter//Peroxidase, family 2 GO:0055085//GO:0006979//GO:0006804 transmembrane transport//response to oxidative stress//obsolete peroxidase reaction GO:0022857//GO:0004601 transmembrane transporter activity//peroxidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.54186 BF_2 12.95 0.53 1300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54189 BF_2 9.74 0.42 1250 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54190 BF_2 13.20 0.67 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54191 BF_2 8.05 0.36 1218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54193 BF_2 9.00 0.67 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54194 BF_2 362.57 6.44 2643 91093683 XP_970017.1 1672 2.3e-183 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|642921701|ref|XP_008194730.1| PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase delta [Tribolium castaneum]>gi|270008077|gb|EFA04525.1| hypothetical protein TcasGA2_TC016320 [Tribolium castaneum] -- -- -- -- -- K13523 AGPAT3_4 lysophosphatidic acid acyltransferase / lysophosphatidylinositol acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13523 Q924S1 733 7.1e-76 1-acyl-sn-glycerol-3-phosphate acyltransferase delta OS=Rattus norvegicus GN=Agpat4 PE=2 SV=1 PF01553//PF00115//PF04589 Acyltransferase//Cytochrome C and Quinol oxidase polypeptide I//RFX1 transcription activation region GO:0009060//GO:0006123//GO:0006355//GO:0006118//GO:0015992//GO:0055114//GO:0008152 aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen//regulation of transcription, DNA-templated//obsolete electron transport//proton transport//oxidation-reduction process//metabolic process GO:0005506//GO:0003677//GO:0016746//GO:0009055//GO:0004129//GO:0020037 iron ion binding//DNA binding//transferase activity, transferring acyl groups//electron carrier activity//cytochrome-c oxidase activity//heme binding GO:0016021//GO:0005634//GO:0045277 integral component of membrane//nucleus//respiratory chain complex IV KOG1505 Lysophosphatidic acid acyltransferase LPAAT and related acyltransferases Cluster-8309.54197 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54202 BF_2 66.71 3.01 1214 642933983 XP_008197591.1 755 2.2e-77 PREDICTED: protein FAM45A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7G4 438 5.3e-42 Protein FAM45A OS=Danio rerio GN=fam45a PE=2 SV=1 PF03495 Clostridial binary toxin B/anthrax toxin PA GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.54203 BF_2 77.39 3.82 1135 642933983 XP_008197591.1 783 1.2e-80 PREDICTED: protein FAM45A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7G4 445 7.6e-43 Protein FAM45A OS=Danio rerio GN=fam45a PE=2 SV=1 PF03495 Clostridial binary toxin B/anthrax toxin PA GO:0009405 pathogenesis -- -- GO:0005576 extracellular region -- -- Cluster-8309.54204 BF_2 67.83 1.05 2987 91080705 XP_975304.1 881 1.3e-91 PREDICTED: CD151 antigen [Tribolium castaneum]>gi|270005473|gb|EFA01921.1| hypothetical protein TcasGA2_TC007531 [Tribolium castaneum] -- -- -- -- -- K17352 TSPAN11 tetraspanin-11 http://www.genome.jp/dbget-bin/www_bget?ko:K17352 Q9QZA6 364 4.9e-33 CD151 antigen OS=Rattus norvegicus GN=Cd151 PE=1 SV=2 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.54209 BF_2 9.00 1.21 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54211 BF_2 8.03 0.72 755 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14987 NADH dehydrogenase 1 alpha subcomplex subunit 3 -- -- -- -- GO:0005747//GO:0005743 mitochondrial respiratory chain complex I//mitochondrial inner membrane -- -- Cluster-8309.54212 BF_2 22.98 0.33 3236 546684809 ERL94391.1 2059 3.7e-228 hypothetical protein D910_11670 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q90827 873 5.1e-92 Protein NEL OS=Gallus gallus GN=NEL PE=2 SV=1 PF00093//PF07645//PF00008 von Willebrand factor type C domain//Calcium-binding EGF domain//EGF-like domain -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.54215 BF_2 392.20 9.46 2022 332373998 AEE62140.1 738 3.5e-75 unknown [Dendroctonus ponderosae] -- -- -- -- -- K06694 PSMD10 26S proteasome non-ATPase regulatory subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K06694 O75832 405 5.9e-38 26S proteasome non-ATPase regulatory subunit 10 OS=Homo sapiens GN=PSMD10 PE=1 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.54216 BF_2 44.02 0.58 3440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220 Neurohypophysial hormones, N-terminal Domain GO:0007218 neuropeptide signaling pathway GO:0005185 neurohypophyseal hormone activity GO:0005576 extracellular region -- -- Cluster-8309.54218 BF_2 149.75 1.28 5177 642935985 XP_008198257.1 561 3.0e-54 PREDICTED: uncharacterized protein LOC103314318 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A4IG66 285 1.2e-23 Transmembrane protein 201 OS=Danio rerio GN=tmem201 PE=2 SV=1 PF06703//PF01680 Microsomal signal peptidase 25 kDa subunit (SPC25)//SOR/SNZ family GO:0042819//GO:0006465//GO:0042823 vitamin B6 biosynthetic process//signal peptide processing//pyridoxal phosphate biosynthetic process GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane KOG4623 Uncharacterized conserved protein Cluster-8309.54221 BF_2 33.53 0.45 3418 642925144 XP_008194444.1 1180 3.3e-126 PREDICTED: WSCD family member AGAP003962 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q16WU7 876 2.4e-92 WSCD family member AAEL009094 OS=Aedes aegypti GN=AAEL009094 PE=3 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.54224 BF_2 12.11 0.34 1775 546683810 ERL93563.1 568 1.6e-55 hypothetical protein D910_10852 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 392 1.7e-36 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00664 ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.54225 BF_2 15.44 0.72 1184 861599125 KMQ83546.1 396 9.3e-36 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54226 BF_2 10.98 0.37 1522 270010525 EFA06973.1 213 2.0e-14 hypothetical protein TcasGA2_TC009933 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54227 BF_2 10.00 0.32 1592 -- -- -- -- -- 797056881 HG313998.1 34 8.97437e-06 TPA_asm: Oryzias latipes strain Hd-rR, complete genome assembly, chromosome 20 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5423 BF_2 21.47 0.37 2742 478251152 ENN71628.1 1655 2.2e-181 hypothetical protein YQE_11727, partial [Dendroctonus ponderosae]>gi|546685814|gb|ERL95257.1| hypothetical protein D910_12524 [Dendroctonus ponderosae] 642926333 XM_008196659.1 246 2.20169e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q3V3A7 523 1.7e-51 RING finger protein 207 OS=Mus musculus GN=Rnf207 PE=2 SV=2 PF05791//PF10392//PF04728//PF08702//PF04513//PF11802//PF04673//PF01667 Bacillus haemolytic enterotoxin (HBL)//Golgi transport complex subunit 5//Lipoprotein leucine-zipper//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus//Centromere-associated protein K//Polyketide synthesis cyclase//Ribosomal protein S27 GO:0030168//GO:0006891//GO:0006412//GO:0042254//GO:0007165//GO:0009405//GO:0030639//GO:0051258 platelet activation//intra-Golgi vesicle-mediated transport//translation//ribosome biogenesis//signal transduction//pathogenesis//polyketide biosynthetic process//protein polymerization GO:0030674//GO:0003735//GO:0005102//GO:0005198 protein binding, bridging//structural constituent of ribosome//receptor binding//structural molecule activity GO:0017119//GO:0016020//GO:0005634//GO:0019867//GO:0019031//GO:0005840//GO:0005622//GO:0005577//GO:0019028 Golgi transport complex//membrane//nucleus//outer membrane//viral envelope//ribosome//intracellular//fibrinogen complex//viral capsid -- -- Cluster-8309.54230 BF_2 526.19 11.70 2168 478259957 ENN79759.1 1328 1.4e-143 hypothetical protein YQE_03815, partial [Dendroctonus ponderosae]>gi|546681505|gb|ERL91582.1| hypothetical protein D910_08912 [Dendroctonus ponderosae] -- -- -- -- -- K05614 SLC1A3, EAAT1 solute carrier family 1 (glial high affinity glutamate transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05614 P51906 868 1.3e-91 Excitatory amino acid transporter 3 OS=Mus musculus GN=Slc1a1 PE=1 SV=2 PF07810//PF00375 TMC domain//Sodium:dicarboxylate symporter family GO:0006820//GO:0006812//GO:0006835 anion transport//cation transport//dicarboxylic acid transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.54234 BF_2 168.28 1.00 7348 478256459 ENN76644.1 2724 6.5e-305 hypothetical protein YQE_06823, partial [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1598 9.9e-176 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF05148//PF10391//PF05206//PF08241//PF05175 Hypothetical methyltransferase//Fingers domain of DNA polymerase lambda//Methyltransferase TRM13//Methyltransferase domain//Methyltransferase small domain GO:0008152//GO:0008033 metabolic process//tRNA processing GO:0008168//GO:0003677//GO:0034061 methyltransferase activity//DNA binding//DNA polymerase activity GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.54238 BF_2 11.00 0.46 1294 195119400 XP_002004219.1 172 9.6e-10 GI19798 [Drosophila mojavensis]>gi|193909287|gb|EDW08154.1| GI19798 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- Q80VQ0 130 2.9e-06 Aldehyde dehydrogenase family 3 member B1 OS=Mus musculus GN=Aldh3b1 PE=2 SV=1 PF00171 Aldehyde dehydrogenase family GO:0055114//GO:0008152//GO:0044710 oxidation-reduction process//metabolic process//single-organism metabolic process GO:0016491//GO:0016620 oxidoreductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG2456 Aldehyde dehydrogenase Cluster-8309.54249 BF_2 9.69 0.61 950 642929723 XP_008195952.1 853 7.6e-89 PREDICTED: spastin [Tribolium castaneum]>gi|270010589|gb|EFA07037.1| hypothetical protein TcasGA2_TC010011 [Tribolium castaneum] -- -- -- -- -- K13254 SPAST spastin http://www.genome.jp/dbget-bin/www_bget?ko:K13254 B3P8A3 518 2.2e-51 Spastin OS=Drosophila erecta GN=spas PE=3 SV=1 PF00515//PF13414 Tetratricopeptide repeat//TPR repeat -- -- GO:0005524//GO:0008568//GO:0005515 ATP binding//microtubule-severing ATPase activity//protein binding -- -- -- -- Cluster-8309.5425 BF_2 1.89 0.57 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54250 BF_2 15.00 1.10 857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54252 BF_2 1.00 0.65 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54261 BF_2 46.38 1.12 2016 828177651 AKK25148.1 438 2.1e-40 chemosensory protein 4 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W1C9 251 4.2e-20 Ejaculatory bulb-specific protein 3 OS=Drosophila melanogaster GN=PebIII PE=1 SV=2 PF06209//PF08613//PF00957//PF01299 Cofactor of BRCA1 (COBRA1)//Cyclin//Synaptobrevin//Lysosome-associated membrane glycoprotein (Lamp) GO:0016192//GO:0000079//GO:0045892 vesicle-mediated transport//regulation of cyclin-dependent protein serine/threonine kinase activity//negative regulation of transcription, DNA-templated GO:0019901 protein kinase binding GO:0016020//GO:0005634//GO:0016021 membrane//nucleus//integral component of membrane -- -- Cluster-8309.54262 BF_2 109.89 2.46 2156 642935609 XP_008198080.1 2765 3.4e-310 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7C5 1453 1.9e-159 Phosphatidylinositide phosphatase SAC2 OS=Danio rerio GN=inpp5f PE=3 SV=1 PF03092//PF02383//PF03611 BT1 family//SacI homology domain//PTS system sugar-specific permease component GO:0009401//GO:0006810 phosphoenolpyruvate-dependent sugar phosphotransferase system//transport GO:0042578 phosphoric ester hydrolase activity GO:0016021 integral component of membrane KOG1889 Putative phosphoinositide phosphatase Cluster-8309.54263 BF_2 109.61 1.68 3018 642936951 XP_008198626.1 327 2.4e-27 PREDICTED: protein ENL [Tribolium castaneum]>gi|270000916|gb|EEZ97363.1| hypothetical protein TcasGA2_TC011185 [Tribolium castaneum] -- -- -- -- -- K15187 MLLT1_3, ENL, AF9 YEATS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K15187 P42568 147 7.3e-08 Protein AF-9 OS=Homo sapiens GN=MLLT3 PE=1 SV=2 PF03286//PF09768 Pox virus Ag35 surface protein//Peptidase M76 family -- -- GO:0004222 metalloendopeptidase activity GO:0019031 viral envelope -- -- Cluster-8309.54264 BF_2 20.36 0.37 2606 91092950 XP_972452.1 1463 3.8e-159 PREDICTED: probable glutamine--tRNA ligase [Tribolium castaneum]>gi|270003024|gb|EEZ99471.1| hypothetical protein TcasGA2_TC000042 [Tribolium castaneum] 815821208 XM_012376424.1 72 1.11361e-26 PREDICTED: Linepithema humile probable glutamine--tRNA ligase (LOC105677665), mRNA K01886 QARS, glnS glutaminyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01886 Q9Y105 1171 1.1e-126 Probable glutamine--tRNA ligase OS=Drosophila melanogaster GN=Aats-gln PE=2 SV=1 PF03950//PF00749//PF04558//PF04557//PF07499 tRNA synthetases class I (E and Q), anti-codon binding domain//tRNA synthetases class I (E and Q), catalytic domain//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//RuvA, C-terminal domain GO:0006310//GO:0006418//GO:0043039//GO:0006425//GO:0006281 DNA recombination//tRNA aminoacylation for protein translation//tRNA aminoacylation//glutaminyl-tRNA aminoacylation//DNA repair GO:0000166//GO:0004819//GO:0004812//GO:0009378//GO:0016876//GO:0005524 nucleotide binding//glutamine-tRNA ligase activity//aminoacyl-tRNA ligase activity//four-way junction helicase activity//ligase activity, forming aminoacyl-tRNA and related compounds//ATP binding GO:0005737//GO:0009379//GO:0005657 cytoplasm//Holliday junction helicase complex//replication fork KOG1148 Glutaminyl-tRNA synthetase Cluster-8309.54267 BF_2 355.46 34.59 717 91080999 XP_975088.1 382 2.4e-34 PREDICTED: mannose-6-phosphate isomerase [Tribolium castaneum]>gi|270005346|gb|EFA01794.1| hypothetical protein TcasGA2_TC007395 [Tribolium castaneum] -- -- -- -- -- K01809 manA, MPI mannose-6-phosphate isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01809 Q8HXX2 297 6.9e-26 Mannose-6-phosphate isomerase OS=Macaca fascicularis GN=MPI PE=2 SV=3 PF01238 Phosphomannose isomerase type I GO:0044238//GO:0006013//GO:0006000//GO:0005975//GO:0071704 primary metabolic process//mannose metabolic process//fructose metabolic process//carbohydrate metabolic process//organic substance metabolic process GO:0008270//GO:0004476//GO:0016853 zinc ion binding//mannose-6-phosphate isomerase activity//isomerase activity -- -- KOG2757 Mannose-6-phosphate isomerase Cluster-8309.54273 BF_2 16.39 0.35 2260 270015520 EFA11968.1 551 1.9e-53 hypothetical protein TcasGA2_TC004049 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q87040 199 5.1e-14 Pro-Pol polyprotein OS=Simian foamy virus (isolate chimpanzee) GN=pol PE=3 SV=1 PF13683//PF00665//PF04561 Integrase core domain//Integrase core domain//RNA polymerase Rpb2, domain 2 GO:0006206//GO:0006351//GO:0015074//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//DNA integration//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.54274 BF_2 230.99 2.05 5005 642928077 XP_008200146.1 1753 1.7e-192 PREDICTED: homer protein homolog 2 [Tribolium castaneum]>gi|270010897|gb|EFA07345.1| hypothetical protein TcasGA2_TC015941 [Tribolium castaneum] -- -- -- -- -- K15010 HOMER homer http://www.genome.jp/dbget-bin/www_bget?ko:K15010 Q9QWW1 681 1.4e-69 Homer protein homolog 2 OS=Mus musculus GN=Homer2 PE=1 SV=1 PF10473//PF07989//PF03938//PF07926//PF00038//PF16940//PF15898//PF16716//PF06703//PF13851//PF06810 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Centrosomin N-terminal motif 1//Outer membrane protein (OmpH-like)//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Chloroplast envelope transporter//cGMP-dependent protein kinase interacting domain//Bone marrow stromal antigen 2//Microsomal signal peptidase 25 kDa subunit (SPC25)//Growth-arrest specific micro-tubule binding//Phage minor structural protein GP20 GO:0006606//GO:0048870//GO:0006465//GO:0051607 protein import into nucleus//cell motility//signal peptide processing//defense response to virus GO:0019901//GO:0051082//GO:0008233//GO:0008134//GO:0045502//GO:0005198//GO:0042803 protein kinase binding//unfolded protein binding//peptidase activity//transcription factor binding//dynein binding//structural molecule activity//protein homodimerization activity GO:0009507//GO:0005787//GO:0031514//GO:0005815//GO:0016021//GO:0005882//GO:0030286//GO:0005667 chloroplast//signal peptidase complex//motile cilium//microtubule organizing center//integral component of membrane//intermediate filament//dynein complex//transcription factor complex -- -- Cluster-8309.54276 BF_2 34.00 0.48 3226 270009219 EFA05667.1 1914 2.4e-211 lim1 [Tribolium castaneum] 642926611 XM_008196718.1 618 0 PREDICTED: Tribolium castaneum LIM/homeobox protein Lhx5 (LOC657972), transcript variant X2, mRNA K09372 LHX1 LIM homeobox protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09372 P52889 847 5.3e-89 LIM/homeobox protein Lhx5 OS=Danio rerio GN=lhx5 PE=2 SV=1 PF05920//PF00412//PF00046 Homeobox KN domain//LIM domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.5428 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54281 BF_2 161.76 3.79 2073 270016968 EFA13414.1 2409 6.2e-269 hypothetical protein TcasGA2_TC010300 [Tribolium castaneum] 701368608 XM_010009070.1 66 1.91081e-23 PREDICTED: Chaetura pelagica tripartite motif containing 37 (TRIM37), mRNA K10608 TRIM37, MUL tripartite motif-containing protein 37 http://www.genome.jp/dbget-bin/www_bget?ko:K10608 Q6PCX9 1742 5.6e-193 E3 ubiquitin-protein ligase TRIM37 OS=Mus musculus GN=Trim37 PE=1 SV=1 PF00643//PF01442//PF04632//PF00917 B-box zinc finger//Apolipoprotein A1/A4/E domain//Fusaric acid resistance protein family//MATH domain GO:0042157//GO:0006869//GO:0006810 lipoprotein metabolic process//lipid transport//transport GO:0008289//GO:0005515//GO:0008270 lipid binding//protein binding//zinc ion binding GO:0005886//GO:0005576//GO:0005622 plasma membrane//extracellular region//intracellular -- -- Cluster-8309.54282 BF_2 171.00 7.56 1233 642940459 XP_008196455.1 401 2.5e-36 PREDICTED: uncharacterized protein LOC661701 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54285 BF_2 46.00 0.97 2272 124107284 BAF45419.1 1378 2.4e-149 arrestin1 precursor [Dianemobius nigrofasciatus] 195117905 XM_002003450.1 56 7.59711e-18 Drosophila mojavensis GI17937 (Dmoj\GI17937), mRNA K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P55274 1253 3.1e-136 Arrestin homolog OS=Heliothis virescens PE=3 SV=1 PF00367//PF11909 phosphotransferase system, EIIB//NADH-quinone oxidoreductase cyanobacterial subunit N GO:0006118//GO:0008643//GO:0055114 obsolete electron transport//carbohydrate transport//oxidation-reduction process GO:0008982//GO:0016655 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor GO:0009357//GO:0016020 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//membrane KOG3865 Arrestin Cluster-8309.54286 BF_2 91.00 2.58 1762 815791214 XP_012216180.1 1232 1.6e-132 PREDICTED: arrestin homolog [Linepithema humile] -- -- -- -- -- K04439 ARRB beta-arrestin http://www.genome.jp/dbget-bin/www_bget?ko:K04439 P32122 1227 2.5e-133 Arrestin homolog OS=Locusta migratoria PE=2 SV=1 PF05294 Scorpion short toxin GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG3865 Arrestin Cluster-8309.54288 BF_2 436.06 4.60 4252 642915350 XP_008190583.1 906 2.4e-94 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K17410 MRPS31 small subunit ribosomal protein S31 http://www.genome.jp/dbget-bin/www_bget?ko:K17410 P82925 417 5.0e-39 28S ribosomal protein S31, mitochondrial OS=Bos taurus GN=MRPS31 PE=1 SV=3 PF15965//PF15433//PF03145 TRAF-like zinc-finger//Mitochondrial 28S ribosomal protein S31//Seven in absentia protein family GO:0006511//GO:0042254//GO:0007275 ubiquitin-dependent protein catabolic process//ribosome biogenesis//multicellular organismal development GO:0003735//GO:0008270 structural constituent of ribosome//zinc ion binding GO:0005840//GO:0005634//GO:0005763 ribosome//nucleus//mitochondrial small ribosomal subunit KOG3002 Zn finger protein Cluster-8309.54289 BF_2 24.94 0.31 3631 282158101 NP_001164094.1 893 6.7e-93 mitochondrial ribosomal protein S31 [Tribolium castaneum]>gi|270010145|gb|EFA06593.1| hypothetical protein TcasGA2_TC009507 [Tribolium castaneum] -- -- -- -- -- K17410 MRPS31 small subunit ribosomal protein S31 http://www.genome.jp/dbget-bin/www_bget?ko:K17410 P82925 417 4.3e-39 28S ribosomal protein S31, mitochondrial OS=Bos taurus GN=MRPS31 PE=1 SV=3 PF15433 Mitochondrial 28S ribosomal protein S31 GO:0042254 ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005763//GO:0005840 mitochondrial small ribosomal subunit//ribosome KOG3002 Zn finger protein Cluster-8309.5429 BF_2 27.34 0.91 1547 642920521 XP_008192385.1 1179 1.9e-126 PREDICTED: uncharacterized protein LOC663775 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96BD5 189 5.0e-13 PHD finger protein 21A OS=Homo sapiens GN=PHF21A PE=1 SV=1 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54291 BF_2 9.57 1.03 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54294 BF_2 28.58 0.92 1585 808127576 XP_012166717.1 344 1.3e-29 PREDICTED: uncharacterized protein LOC105666020 [Bombus terrestris] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.54295 BF_2 272.27 2.45 4940 270013369 EFA09817.1 818 4.5e-84 hypothetical protein TcasGA2_TC011963 [Tribolium castaneum] -- -- -- -- -- K17963 PPRC1, PRC peroxisome proliferator-activated receptor gamma coactivator-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17963 Q6NZN1 232 1.7e-17 Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Mus musculus GN=Pprc1 PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.54299 BF_2 4.00 0.59 573 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54300 BF_2 121.82 6.53 1068 332374952 AEE62617.1 735 4.1e-75 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q922Q1 198 3.1e-14 Mitochondrial amidoxime reducing component 2 OS=Mus musculus GN=Marc2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54306 BF_2 130.31 1.08 5324 270014503 EFA10951.1 4359 0.0e+00 hypothetical protein TcasGA2_TC004111 [Tribolium castaneum] 665818753 XM_008559999.1 110 1.72069e-47 PREDICTED: Microplitis demolitor putative DNA helicase Ino80 (LOC103578813), mRNA K11665 INO80, INOC1 DNA helicase INO80 http://www.genome.jp/dbget-bin/www_bget?ko:K11665 Q9VDY1 2634 5.3e-296 Putative DNA helicase Ino80 OS=Drosophila melanogaster GN=Ino80 PE=1 SV=2 PF00176//PF13892 SNF2 family N-terminal domain//DNA-binding domain -- -- GO:0003677//GO:0005524 DNA binding//ATP binding -- -- KOG0388 SNF2 family DNA-dependent ATPase Cluster-8309.54307 BF_2 248.72 9.14 1426 642918280 XP_008191442.1 832 3.1e-86 PREDICTED: UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit isoform X1 [Tribolium castaneum]>gi|270004555|gb|EFA01003.1| hypothetical protein TcasGA2_TC003916 [Tribolium castaneum] 642918281 XM_008193221.1 184 3.30751e-89 PREDICTED: Tribolium castaneum UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (LOC655930), transcript variant X2, mRNA K09667 OGT protein O-GlcNAc transferase http://www.genome.jp/dbget-bin/www_bget?ko:K09667 P56558 732 5.0e-76 UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit OS=Rattus norvegicus GN=Ogt PE=1 SV=1 PF13174//PF13181//PF07721//PF13176//PF13414//PF13371//PF00515//PF13374 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515//GO:0042802 protein binding//identical protein binding -- -- KOG4626 O-linked N-acetylglucosamine transferase OGT Cluster-8309.54308 BF_2 9.20 0.43 1183 332374122 AEE62202.1 703 2.3e-71 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9D0I8 565 9.6e-57 mRNA turnover protein 4 homolog OS=Mus musculus GN=Mrto4 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0816 Protein involved in mRNA turnover Cluster-8309.54309 BF_2 271.78 30.49 660 189241797 XP_001812480.1 300 7.0e-25 PREDICTED: cytochrome c oxidase subunit 6C [Tribolium castaneum]>gi|270001250|gb|EEZ97697.1| hypothetical protein TcasGA2_TC011006 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P04038 152 4.2e-09 Cytochrome c oxidase subunit 6C OS=Bos taurus GN=COX6C PE=1 SV=2 -- -- GO:0006123//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//proton transport GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.5431 BF_2 8.00 0.44 1051 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54311 BF_2 6.00 0.37 962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54315 BF_2 6.86 1.32 505 642939494 XP_008190865.1 446 6.3e-42 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003824//GO:0043167 catalytic activity//ion binding -- -- -- -- Cluster-8309.54316 BF_2 106.24 1.01 4706 478254095 ENN74383.1 3675 0.0e+00 hypothetical protein YQE_09040, partial [Dendroctonus ponderosae] -- -- -- -- -- K02332 POLG1 DNA polymerase gamma 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02332 Q27607 2892 0.0e+00 DNA polymerase subunit gamma-1, mitochondrial OS=Drosophila melanogaster GN=tam PE=1 SV=2 PF01612//PF00476//PF01300//PF07834//PF01176 3'-5' exonuclease//DNA polymerase family A//Telomere recombination//RanGAP1 C-terminal domain//Translation initiation factor 1A / IF-1 GO:0006139//GO:0006446//GO:0007165//GO:0006413//GO:0006260 nucleobase-containing compound metabolic process//regulation of translational initiation//signal transduction//translational initiation//DNA replication GO:0003887//GO:0003723//GO:0003677//GO:0005096//GO:0003743//GO:0003725//GO:0008408//GO:0003676 DNA-directed DNA polymerase activity//RNA binding//DNA binding//GTPase activator activity//translation initiation factor activity//double-stranded RNA binding//3'-5' exonuclease activity//nucleic acid binding GO:0042575//GO:0005840 DNA polymerase complex//ribosome KOG3657 Mitochondrial DNA polymerase gamma, catalytic subunit Cluster-8309.54317 BF_2 186.85 2.76 3118 478257137 ENN77300.1 376 5.1e-33 hypothetical protein YQE_06126, partial [Dendroctonus ponderosae]>gi|546681456|gb|ERL91553.1| hypothetical protein D910_08883 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05273 Poxvirus RNA polymerase 22 kDa subunit GO:0006206//GO:0019083//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//viral transcription//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.54321 BF_2 23.50 0.82 1492 91088999 XP_967603.1 906 8.5e-95 PREDICTED: frizzled-4 [Tribolium castaneum]>gi|270012807|gb|EFA09255.1| frizzled 4 [Tribolium castaneum] 642932599 XM_962510.2 141 2.77461e-65 PREDICTED: Tribolium castaneum frizzled 4 (LOC655955), mRNA -- -- -- -- Q61088 271 1.5e-22 Frizzled-4 OS=Mus musculus GN=Fzd4 PE=1 SV=1 PF01529//PF01534 DHHC palmitoyltransferase//Frizzled/Smoothened family membrane region GO:0007165//GO:0007166 signal transduction//cell surface receptor signaling pathway GO:0008270//GO:0004888 zinc ion binding//transmembrane signaling receptor activity GO:0016020 membrane KOG3577 Smoothened and related G-protein-coupled receptors Cluster-8309.54326 BF_2 5.00 1.52 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54327 BF_2 2.00 0.32 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54331 BF_2 366.36 5.22 3223 546676741 ERL87697.1 467 1.5e-43 hypothetical protein D910_05087 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P45583 220 2.7e-16 Cuticle protein 19 OS=Locusta migratoria PE=1 SV=1 PF02008//PF00379 CXXC zinc finger domain//Insect cuticle protein -- -- GO:0042302//GO:0003677//GO:0008270 structural constituent of cuticle//DNA binding//zinc ion binding -- -- -- -- Cluster-8309.54332 BF_2 303.95 18.43 977 642936711 XP_008200418.1 1073 2.4e-114 PREDICTED: eukaryotic initiation factor 4E isoform X1 [Tribolium castaneum] 642936710 XM_008202196.1 160 4.92435e-76 PREDICTED: Tribolium castaneum eukaryotic initiation factor 4E (eIF-4E), transcript variant X1, mRNA K03259 EIF4E translation initiation factor 4E http://www.genome.jp/dbget-bin/www_bget?ko:K03259 O60573 608 8.2e-62 Eukaryotic translation initiation factor 4E type 2 OS=Homo sapiens GN=EIF4E2 PE=1 SV=1 PF01652 Eukaryotic initiation factor 4E GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003723 translation initiation factor activity//RNA binding GO:0005737//GO:0005840 cytoplasm//ribosome KOG1670 Translation initiation factor 4F, cap-binding subunit (eIF-4E) and related cap-binding proteins Cluster-8309.54334 BF_2 20.24 2.91 578 270012966 EFA09414.1 154 5.2e-08 hypothetical protein TcasGA2_TC005216 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54337 BF_2 5.98 0.50 785 642934075 XP_008196143.1 327 6.2e-28 PREDICTED: sin3 histone deacetylase corepressor complex component SDS3 [Tribolium castaneum]>gi|270012950|gb|EFA09398.1| hypothetical protein TcasGA2_TC004316 [Tribolium castaneum] 347964404 XM_559379.4 34 4.33003e-06 Anopheles gambiae str. PEST AGAP000738-PA (AgaP_AGAP000738) mRNA, complete cds K19201 SUDS3, SAP45 Sin3 histone deacetylase corepressor complex component SDS3 http://www.genome.jp/dbget-bin/www_bget?ko:K19201 Q9H7L9 179 3.7e-12 Sin3 histone deacetylase corepressor complex component SDS3 OS=Homo sapiens GN=SUDS3 PE=1 SV=2 PF02046 Cytochrome c oxidase subunit VIa GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743//GO:0005751 respiratory chain complex IV//mitochondrial inner membrane//mitochondrial respiratory chain complex IV -- -- Cluster-8309.54338 BF_2 21.38 0.49 2099 158298785 XP_553715.3 203 3.9e-13 AGAP009835-PA [Anopheles gambiae str. PEST]>gi|157014052|gb|EAL39215.3| AGAP009835-PA [Anopheles gambiae str. PEST] -- -- -- -- -- K05665 ABCC1 ATP-binding cassette, subfamily C (CFTR/MRP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05665 Q92887 184 2.6e-12 Canalicular multispecific organic anion transporter 1 OS=Homo sapiens GN=ABCC2 PE=1 SV=3 PF01120 Alpha-L-fucosidase GO:0055085//GO:0006200//GO:0006810//GO:0005975 transmembrane transport//obsolete ATP catabolic process//transport//carbohydrate metabolic process GO:0004560//GO:0005524//GO:0042626 alpha-L-fucosidase activity//ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.54339 BF_2 11.43 0.48 1279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00319 SRF-type transcription factor (DNA-binding and dimerisation domain) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding -- -- -- -- Cluster-8309.54340 BF_2 3.00 0.44 570 91079616 XP_967067.1 167 1.6e-09 PREDICTED: thyroid receptor-interacting protein 11 [Tribolium castaneum]>gi|270003380|gb|EEZ99827.1| hypothetical protein TcasGA2_TC002608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54342 BF_2 14.00 0.83 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54343 BF_2 116.00 1.12 4628 91093699 XP_966579.1 1805 1.5e-198 PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|270014224|gb|EFA10672.1| hypothetical protein TcasGA2_TC010654, partial [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VXD9 988 3.4e-105 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF00002//PF00503 7 transmembrane receptor (Secretin family)//G-protein alpha subunit GO:0007186//GO:0007166//GO:0007165 G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway//signal transduction GO:0019001//GO:0004871//GO:0004888//GO:0031683//GO:0004930//GO:0003924 guanyl nucleotide binding//signal transducer activity//transmembrane signaling receptor activity//G-protein beta/gamma-subunit complex binding//G-protein coupled receptor activity//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.54345 BF_2 28.47 0.45 2913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54347 BF_2 26.43 0.41 2996 332376975 AEE63627.1 1323 7.6e-143 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 118 3.43976e-52 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1198 9.7e-130 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF00382//PF01857//PF02984 Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain//Cyclin, C-terminal domain GO:0051726 regulation of cell cycle GO:0017025 TBP-class protein binding GO:0005634 nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.54349 BF_2 4.00 0.82 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5435 BF_2 3.00 0.37 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54351 BF_2 18.00 5.76 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54352 BF_2 13.50 0.35 1921 642911474 XP_008199438.1 352 1.9e-30 PREDICTED: protein dispatched isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNJ5 192 2.8e-13 Protein dispatched OS=Drosophila melanogaster GN=disp PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54354 BF_2 4.63 0.62 599 270001858 EEZ98305.1 373 2.2e-33 hypothetical protein TcasGA2_TC000758 [Tribolium castaneum] -- -- -- -- -- K13147 INTS10 integrator complex subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13147 Q6TNU3 152 3.8e-09 Integrator complex subunit 10 OS=Danio rerio GN=ints10 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54358 BF_2 40.02 1.69 1279 642920916 XP_008192614.1 157 5.2e-08 PREDICTED: outer dense fiber protein 3 isoform X3 [Tribolium castaneum] 462345164 APGK01034774.1 43 7.11972e-11 Dendroctonus ponderosae Seq01034784, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54365 BF_2 67.62 1.51 2155 227018336 ACP18834.1 1131 1.0e-120 unknown [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54371 BF_2 4.00 0.33 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54375 BF_2 6.00 0.75 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54376 BF_2 39.24 0.32 5340 546686113 ERL95505.1 501 2.8e-47 hypothetical protein D910_12767 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434//PF00520//PF10798//PF02706//PF15957 TMEM9//Ion transport protein//Biofilm development protein YmgB/AriR//Chain length determinant protein//Commissureless GO:0009103//GO:0007411//GO:0055085//GO:0071229//GO:0042710//GO:0006811 lipopolysaccharide biosynthetic process//axon guidance//transmembrane transport//cellular response to acid chemical//biofilm formation//ion transport GO:0005216 ion channel activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.54380 BF_2 59.10 0.38 6795 861628028 KMQ89256.1 1306 1.6e-140 piggybac transposable element-derived protein 4-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- Q96DM1 293 1.9e-24 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF07776//PF01609//PF07062 Zinc-finger associated domain (zf-AD)//Transposase DDE domain//Clc-like GO:0006313 transposition, DNA-mediated GO:0004803//GO:0008270//GO:0003677 transposase activity//zinc ion binding//DNA binding GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.54381 BF_2 12.00 0.75 958 478257567 ENN77721.1 244 3.2e-18 hypothetical protein YQE_05792, partial [Dendroctonus ponderosae]>gi|546675129|gb|ERL86373.1| hypothetical protein D910_03781 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9C6W5 134 7.4e-07 ABC transporter G family member 14 OS=Arabidopsis thaliana GN=ABCG14 PE=2 SV=1 PF01061 ABC-2 type transporter -- -- -- -- GO:0016020 membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.54386 BF_2 281.42 3.43 3715 642929553 XP_008195882.1 2577 3.7e-288 PREDICTED: DNA excision repair protein ERCC-6-like [Tribolium castaneum] 645002912 XM_008209837.1 96 7.25602e-40 PREDICTED: Nasonia vitripennis DNA excision repair protein ERCC-6-like (LOC100118952), transcript variant X3, mRNA K10841 ERCC6, CSB, RAD26 DNA excision repair protein ERCC-6 http://www.genome.jp/dbget-bin/www_bget?ko:K10841 Q03468 1642 3.9e-181 DNA excision repair protein ERCC-6 OS=Homo sapiens GN=ERCC6 PE=1 SV=1 PF00176 SNF2 family N-terminal domain -- -- GO:0005524 ATP binding -- -- KOG0387 Transcription-coupled repair protein CSB/RAD26 (contains SNF2 family DNA-dependent ATPase domain) Cluster-8309.5439 BF_2 128.51 3.16 1991 91091470 XP_973218.1 867 3.8e-90 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 375 1.7e-34 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF07194//PF05648 P2 response regulator binding domain//Peroxisomal biogenesis factor 11 (PEX11) GO:0016559//GO:0016310//GO:0000160//GO:0006928 peroxisome fission//phosphorylation//phosphorelay signal transduction system//movement of cell or subcellular component GO:0004673//GO:0000155 protein histidine kinase activity//phosphorelay sensor kinase activity GO:0005779//GO:0009365 integral component of peroxisomal membrane//protein histidine kinase complex KOG4186 Peroxisomal biogenesis protein (peroxin) Cluster-8309.54397 BF_2 74.50 4.07 1053 270015871 EFA12319.1 1095 7.3e-117 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 416 1.6e-39 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 PF13499//PF13405//PF00036//PF13833 EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.54399 BF_2 181.00 4.30 2047 270015871 EFA12319.1 2664 1.6e-298 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P08487 1627 1.2e-179 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Bos taurus GN=PLCG1 PE=1 SV=1 PF14604//PF00018//PF03009 Variant SH3 domain//SH3 domain//Glycerophosphoryl diester phosphodiesterase family GO:0006629 lipid metabolic process GO:0005515//GO:0008081 protein binding//phosphoric diester hydrolase activity -- -- KOG1264 Phospholipase C Cluster-8309.54400 BF_2 96.20 2.05 2254 759078999 XP_011349304.1 1444 5.3e-157 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 isoform X2 [Cerapachys biroi] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P19174 807 1.6e-84 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Homo sapiens GN=PLCG1 PE=1 SV=1 PF00168//PF00387 C2 domain//Phosphatidylinositol-specific phospholipase C, Y domain GO:0009395//GO:0046339//GO:0007165//GO:0006629//GO:0035556 phospholipid catabolic process//diacylglycerol metabolic process//signal transduction//lipid metabolic process//intracellular signal transduction GO:0004435//GO:0005515 phosphatidylinositol phospholipase C activity//protein binding -- -- KOG1264 Phospholipase C Cluster-8309.54401 BF_2 146.91 1.50 4377 270297228 NP_001161905.1 744 1.5e-75 cuticular protein analogous to peritrophins 1-C precursor [Tribolium castaneum]>gi|268309004|gb|ACY95468.1| cuticular protein analogous to peritrophins 1-C [Tribolium castaneum]>gi|270001482|gb|EEZ97929.1| hypothetical protein TcasGA2_TC000316 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.54403 BF_2 11.00 0.63 1019 646723359 KDR23993.1 167 2.9e-09 hypothetical protein L798_07932, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54407 BF_2 198.00 10.46 1079 270013655 EFA10103.1 769 4.7e-79 hypothetical protein TcasGA2_TC012282 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9XT55 256 6.0e-21 UDP-glucuronosyltransferase 2B19 OS=Macaca fascicularis GN=UGT2B19 PE=1 SV=1 PF03033//PF00201 Glycosyltransferase family 28 N-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0005975//GO:0030259//GO:0008152 carbohydrate metabolic process//lipid glycosylation//metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54408 BF_2 30.30 0.45 3079 270011563 EFA08011.1 1016 3.1e-107 hypothetical protein TcasGA2_TC005600 [Tribolium castaneum] 808137079 XM_012315443.1 86 2.1739e-34 PREDICTED: Bombus terrestris paired mesoderm homeobox protein 2B (LOC100648767), mRNA -- -- -- -- Q8BYH0 351 1.6e-31 Dorsal root ganglia homeobox protein OS=Mus musculus GN=Drgx PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.54409 BF_2 155.74 3.43 2187 642917040 XP_008191094.1 1744 8.4e-192 PREDICTED: uncharacterized protein C18orf8 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96DM3 810 6.9e-85 Uncharacterized protein C18orf8 OS=Homo sapiens GN=C18orf8 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2377 Uncharacterized conserved protein Cluster-8309.54411 BF_2 79.08 0.51 6733 642924251 XP_008194216.1 3999 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] 755881777 XM_005185855.2 73 8.05893e-27 PREDICTED: Musca domestica N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (LOC101896829), transcript variant X1, mRNA K03857 PIGA, GPI3 phosphatidylinositol glycan, class A http://www.genome.jp/dbget-bin/www_bget?ko:K03857 Q64323 1243 1.3e-134 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein OS=Mus musculus GN=Piga PE=2 SV=1 PF03790//PF00621//PF08288//PF02196 KNOX1 domain//RhoGEF domain//PIGA (GPI anchor biosynthesis)//Raf-like Ras-binding domain GO:0035023//GO:0007165//GO:0006506//GO:0043087 regulation of Rho protein signal transduction//signal transduction//GPI anchor biosynthetic process//regulation of GTPase activity GO:0005057//GO:0003677//GO:0005089 receptor signaling protein activity//DNA binding//Rho guanyl-nucleotide exchange factor activity GO:0005634 nucleus KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase Cluster-8309.54413 BF_2 187.71 3.47 2547 665800358 XP_008548139.1 704 3.8e-71 PREDICTED: G1/S-specific cyclin-D2 [Microplitis demolitor]>gi|607303972|gb|EZA45348.1| g1/S-specific cyclin-D2-like protein [Microplitis demolitor] -- -- -- -- -- K10151 CCND2 cyclin D2 http://www.genome.jp/dbget-bin/www_bget?ko:K10151 P30281 485 3.9e-47 G1/S-specific cyclin-D3 OS=Homo sapiens GN=CCND3 PE=1 SV=2 PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.54415 BF_2 54.00 1.76 1568 751960459 AJG05482.1 250 1.0e-18 poor imd response upon knock-in, partial [Sitophilus oryzae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54417 BF_2 10.00 3.30 413 686701325 XP_009239852.1 504 9.7e-49 PREDICTED: discoidin domain-containing receptor 2 [Pongo abelii] 282721095 NG_016290.1 413 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 438 1.8e-42 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54418 BF_2 4.00 0.86 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54420 BF_2 59.18 1.50 1940 546674387 ERL85774.1 2121 1.4e-235 hypothetical protein D910_03189 [Dendroctonus ponderosae] -- -- -- -- -- K06628 CDC45 cell division control protein 45 http://www.genome.jp/dbget-bin/www_bget?ko:K06628 Q9YHZ6 1194 1.8e-129 Cell division control protein 45 homolog OS=Xenopus laevis GN=cdc45 PE=1 SV=2 PF02724 CDC45-like protein GO:0006270 DNA replication initiation -- -- -- -- KOG2475 CDC45 (cell division cycle 45)-like protein Cluster-8309.54421 BF_2 85.30 0.69 5422 642917556 XP_008191255.1 3201 0.0e+00 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.80288e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.3e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.54423 BF_2 23.52 0.96 1311 642922712 XP_008193292.1 409 3.2e-37 PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922714|ref|XP_008193293.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922716|ref|XP_008193294.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum]>gi|642922718|ref|XP_008193295.1| PREDICTED: LIM domain only protein 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P61969 206 4.5e-15 LIM domain transcription factor LMO4 OS=Mus musculus GN=Lmo4 PE=1 SV=1 PF13639//PF00412//PF17123 Ring finger domain//LIM domain//RING-like zinc finger -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.54427 BF_2 11.64 0.58 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03609//PF05505 PTS system sorbose-specific iic component//Ebola nucleoprotein GO:0019074//GO:0009401 viral RNA genome packaging//phosphoenolpyruvate-dependent sugar phosphotransferase system -- -- GO:0016021//GO:0019013 integral component of membrane//viral nucleocapsid -- -- Cluster-8309.54432 BF_2 286.69 2.49 5096 642926382 XP_008194902.1 3527 0.0e+00 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Tribolium castaneum] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q505D1 2365 7.9e-265 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF02891//PF09066//PF00023 Ankyrin repeat//MIZ/SP-RING zinc finger//Beta2-adaptin appendage, C-terminal sub-domain//Ankyrin repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0008270 protein binding//zinc ion binding GO:0030131 clathrin adaptor complex -- -- Cluster-8309.54433 BF_2 55.23 0.36 6664 642926382 XP_008194902.1 2556 1.8e-285 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Tribolium castaneum] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q505D1 1743 1.4e-192 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A OS=Mus musculus GN=Ankrd28 PE=1 SV=1 PF13606//PF02891//PF03604//PF00023//PF09066 Ankyrin repeat//MIZ/SP-RING zinc finger//DNA directed RNA polymerase, 7 kDa subunit//Ankyrin repeat//Beta2-adaptin appendage, C-terminal sub-domain GO:0006144//GO:0016192//GO:0006886//GO:0006351//GO:0006206 purine nucleobase metabolic process//vesicle-mediated transport//intracellular protein transport//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0005515//GO:0003899//GO:0003677//GO:0008270 protein binding//DNA-directed RNA polymerase activity//DNA binding//zinc ion binding GO:0030131//GO:0005730 clathrin adaptor complex//nucleolus -- -- Cluster-8309.54434 BF_2 3.16 0.35 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54436 BF_2 0.78 5.87 241 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54437 BF_2 68.28 3.43 1120 91078738 XP_967649.1 892 2.7e-93 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] 195153530 XM_002017643.1 50 7.98602e-15 Drosophila persimilis GL17308 (Dper\GL17308), mRNA -- -- -- -- Q6DC39 570 2.4e-57 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.54438 BF_2 30.80 2.29 851 91078738 XP_967649.1 739 1.1e-75 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] 195153530 XM_002017643.1 50 6.0079e-15 Drosophila persimilis GL17308 (Dper\GL17308), mRNA -- -- -- -- Q6DC39 456 3.0e-44 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.54439 BF_2 101.79 9.22 749 546684811 ERL94393.1 790 1.2e-81 hypothetical protein D910_11672, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5U5Z8 345 2.0e-31 Cytosolic carboxypeptidase 2 OS=Homo sapiens GN=AGBL2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3641 Zinc carboxypeptidase Cluster-8309.54440 BF_2 64.32 1.88 1721 549084995 BAO00915.1 1987 4.4e-220 broad-complex [Psacothea hilaris]>gi|549150203|dbj|BAO01153.1| broad-complex [Psacothea hilaris] 549150202 AB858990.1 1079 0 Psacothea hilaris PhBR-C_Z2Z3 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q24206 611 6.5e-62 Broad-complex core protein isoform 6 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00096//PF06221//PF02148//PF05443//PF13465//PF16622//PF00651//PF01428//PF13912//PF01363//PF02892 Zinc finger, C2H2 type//Putative zinc finger motif, C2HC5-type//Zn-finger in ubiquitin-hydrolases and other protein//ROS/MUCR transcriptional regulator protein//Zinc-finger double domain//zinc-finger C2H2-type//BTB/POZ domain//AN1-like Zinc finger//C2H2-type zinc finger//FYVE zinc finger//BED zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003677//GO:0005515//GO:0046872 zinc ion binding//DNA binding//protein binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.54441 BF_2 90.70 0.32 12017 549084993 BAO00914.1 2003 4.3e-221 broad-complex [Psacothea hilaris] 549084992 AB857715.1 1041 0 Psacothea hilaris PhBR-C_Z1 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q01295 609 7.8e-61 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF02892//PF03854//PF13912//PF01363//PF00651//PF16622//PF13465//PF00096//PF00130 BED zinc finger//P-11 zinc finger//C2H2-type zinc finger//FYVE zinc finger//BTB/POZ domain//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction GO:0005515//GO:0046872//GO:0003677//GO:0008270//GO:0003723 protein binding//metal ion binding//DNA binding//zinc ion binding//RNA binding -- -- -- -- Cluster-8309.54442 BF_2 154.45 0.55 11953 549084993 BAO00914.1 2003 4.3e-221 broad-complex [Psacothea hilaris] 549084992 AB857715.1 1041 0 Psacothea hilaris PhBR-C_Z1 mRNA for broad-complex, complete cds K02174 BR-C broad http://www.genome.jp/dbget-bin/www_bget?ko:K02174 Q01295 609 7.7e-61 Broad-complex core protein isoforms 1/2/3/4/5 OS=Drosophila melanogaster GN=br PE=1 SV=2 PF00096//PF00130//PF13465//PF02892//PF03854//PF13912//PF01363//PF00651//PF16622 Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//BED zinc finger//P-11 zinc finger//C2H2-type zinc finger//FYVE zinc finger//BTB/POZ domain//zinc-finger C2H2-type GO:0035556 intracellular signal transduction GO:0003723//GO:0008270//GO:0003677//GO:0046872//GO:0005515 RNA binding//zinc ion binding//DNA binding//metal ion binding//protein binding -- -- -- -- Cluster-8309.54448 BF_2 3.22 0.35 676 332373388 AEE61835.1 344 5.7e-30 unknown [Dendroctonus ponderosae] 153912708 AK281733.1 34 3.70157e-06 Gryllus bimaculatus mRNA, GBcontig28594 K01187 malZ alpha-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K01187 O16099 248 3.2e-20 Maltase 2 OS=Drosophila virilis GN=Mal-B2 PE=3 SV=2 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006120//GO:0006744//GO:0015992//GO:0055114 sodium ion transport//mitochondrial electron transport, NADH to ubiquinone//ubiquinone biosynthetic process//proton transport//oxidation-reduction process GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- -- -- Cluster-8309.54449 BF_2 68.32 0.51 5850 642926380 XP_008194901.1 2852 0.0e+00 PREDICTED: uncharacterized protein LOC655777 [Tribolium castaneum] 641673871 XM_001952487.3 158 3.92495e-74 PREDICTED: Acyrthosiphon pisum uncharacterized LOC100160518 (LOC100160518), partial mRNA -- -- -- -- Q9JJZ8 911 3.6e-96 Cyclic nucleotide-gated cation channel alpha-3 OS=Mus musculus GN=Cnga3 PE=1 SV=2 PF03938//PF00520 Outer membrane protein (OmpH-like)//Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0051082//GO:0005216 unfolded protein binding//ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.54450 BF_2 3.00 0.49 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54452 BF_2 307.00 7.76 1943 189236231 XP_972574.2 1290 3.3e-139 PREDICTED: glucose dehydrogenase [FAD, quinone] [Tribolium castaneum]>gi|270005539|gb|EFA01987.1| hypothetical protein TcasGA2_TC007608 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 862 5.8e-91 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF01266//PF05834//PF07992//PF00732//PF02558//PF05199 FAD dependent oxidoreductase//Lycopene cyclase protein//Pyridine nucleotide-disulphide oxidoreductase//GMC oxidoreductase//Ketopantoate reductase PanE/ApbA//GMC oxidoreductase GO:0055114//GO:0016117//GO:0015940 oxidation-reduction process//carotenoid biosynthetic process//pantothenate biosynthetic process GO:0050660//GO:0008677//GO:0016491//GO:0016614//GO:0016705 flavin adenine dinucleotide binding//2-dehydropantoate 2-reductase activity//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.54456 BF_2 22.38 4.32 504 270011085 EFA07533.1 171 4.9e-10 ADFb like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54460 BF_2 11.00 0.43 1351 546674635 ERL85978.1 177 2.6e-10 hypothetical protein D910_03392 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54461 BF_2 11.00 0.81 857 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54462 BF_2 2.00 0.69 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54463 BF_2 1.00 1.70 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54470 BF_2 11.00 0.41 1407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54473 BF_2 42.11 1.03 2001 642915071 XP_008190398.1 2322 7.3e-259 PREDICTED: protein groucho isoform X4 [Tribolium castaneum] 602715430 XM_007467859.1 376 0 PREDICTED: Lipotes vexillifer transducin-like enhancer of split 3 (TLE3), transcript variant X12, mRNA K04497 GROUCHO groucho http://www.genome.jp/dbget-bin/www_bget?ko:K04497 P16371 1950 4.1e-217 Protein groucho OS=Drosophila melanogaster GN=gro PE=1 SV=3 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0639 Transducin-like enhancer of split protein (contains WD40 repeats) Cluster-8309.54475 BF_2 9.00 2.41 443 664710778 XP_008512356.1 338 1.8e-29 PREDICTED: fibroblast growth factor receptor 2 isoform X10 [Equus przewalskii] 254553324 NG_012449.1 443 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 181 1.2e-12 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54477 BF_2 84.44 0.83 4535 270011590 EFA08038.1 2613 3.0e-292 hypothetical protein TcasGA2_TC005627 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ET47 449 1.0e-42 Espin OS=Mus musculus GN=Espn PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54478 BF_2 289.05 1.81 6971 91080871 XP_972325.1 2663 7.3e-298 PREDICTED: nidogen-1 [Tribolium castaneum]>gi|270005920|gb|EFA02368.1| hypothetical protein TcasGA2_TC008043 [Tribolium castaneum] -- -- -- -- -- K06826 NID nidogen (entactin) http://www.genome.jp/dbget-bin/www_bget?ko:K06826 P10493 679 3.4e-69 Nidogen-1 OS=Mus musculus GN=Nid1 PE=1 SV=2 PF00661//PF07645//PF12861//PF13639//PF01731//PF12678//PF00008//PF06119//PF11789 Viral matrix protein//Calcium-binding EGF domain//Anaphase-promoting complex subunit 11 RING-H2 finger//Ring finger domain//Arylesterase//RING-H2 zinc finger//EGF-like domain//Nidogen-like//Zinc-finger of the MIZ type in Nse subunit GO:0016567//GO:0007160//GO:0019068 protein ubiquitination//cell-matrix adhesion//virion assembly GO:0005198//GO:0004842//GO:0005515//GO:0008270//GO:0005509//GO:0004064 structural molecule activity//ubiquitin-protein transferase activity//protein binding//zinc ion binding//calcium ion binding//arylesterase activity GO:0005680 anaphase-promoting complex KOG1215 Low-density lipoprotein receptors containing Ca2+-binding EGF-like domains Cluster-8309.54481 BF_2 38.86 0.42 4135 270010376 EFA06824.1 2606 1.8e-291 hypothetical protein TcasGA2_TC009766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13590 263 3.5e-21 Neural cell adhesion molecule 1 OS=Gallus gallus GN=NCAM1 PE=1 SV=3 PF00041//PF13895//PF15880//PF02480 Fibronectin type III domain//Immunoglobulin domain//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial//Alphaherpesvirus glycoprotein E -- -- GO:0005515 protein binding GO:0016020//GO:0005739//GO:0005747 membrane//mitochondrion//mitochondrial respiratory chain complex I -- -- Cluster-8309.54482 BF_2 278.00 22.24 810 270013657 EFA10105.1 590 2.0e-58 hypothetical protein TcasGA2_TC012284 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P08542 421 3.3e-40 UDP-glucuronosyltransferase 2B17 OS=Rattus norvegicus GN=Ugt2b17 PE=2 SV=2 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54483 BF_2 34.71 1.26 1439 270015480 EFA11928.1 1042 1.4e-110 hypothetical protein TcasGA2_TC004274 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 500 4.0e-49 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54485 BF_2 398.67 6.02 3059 642939824 XP_008190471.1 1006 4.4e-106 PREDICTED: UDP-glucuronosyltransferase 2C1-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 459 4.9e-44 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54489 BF_2 22.98 0.33 3162 642939824 XP_008190471.1 998 3.9e-105 PREDICTED: UDP-glucuronosyltransferase 2C1-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P54855 459 5.0e-44 UDP-glucuronosyltransferase 2B15 OS=Homo sapiens GN=UGT2B15 PE=1 SV=3 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.54492 BF_2 146.16 0.86 7433 546684778 ERL94373.1 3133 0.0e+00 hypothetical protein D910_11653 [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1698 2.5e-187 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF08241//PF05175//PF05148//PF00270//PF10391//PF05206 Methyltransferase domain//Methyltransferase small domain//Hypothetical methyltransferase//DEAD/DEAH box helicase//Fingers domain of DNA polymerase lambda//Methyltransferase TRM13 GO:0008033//GO:0008152 tRNA processing//metabolic process GO:0008168//GO:0003676//GO:0034061//GO:0005524//GO:0003677 methyltransferase activity//nucleic acid binding//DNA polymerase activity//ATP binding//DNA binding GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.54495 BF_2 32.04 0.32 4433 546686080 ERL95480.1 403 5.4e-36 hypothetical protein D910_12742 [Dendroctonus ponderosae] -- -- -- -- -- K03434 PIGL N-acetylglucosaminylphosphatidylinositol deacetylase http://www.genome.jp/dbget-bin/www_bget?ko:K03434 Q9Y2B2 255 3.2e-20 N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase OS=Homo sapiens GN=PIGL PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3332 N-acetylglucosaminyl phosphatidylinositol de-N-acetylase Cluster-8309.54496 BF_2 8.00 2.62 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5450 BF_2 4.00 9.09 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06403 Lamprin -- -- GO:0005198 structural molecule activity GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.54500 BF_2 13.52 0.44 1580 91077058 XP_968505.1 1179 2.0e-126 PREDICTED: importin subunit alpha-7 [Tribolium castaneum]>gi|270002024|gb|EEZ98471.1| hypothetical protein TcasGA2_TC000963 [Tribolium castaneum] 665802087 XM_008550863.1 127 1.78332e-57 PREDICTED: Microplitis demolitor importin subunit alpha-7 (LOC103572321), mRNA K15043 KPNA2 importin subunit alpha-2 http://www.genome.jp/dbget-bin/www_bget?ko:K15043 O35345 990 6.7e-106 Importin subunit alpha-7 OS=Mus musculus GN=Kpna6 PE=1 SV=2 PF11698//PF00514//PF01602//PF02985//PF10508 V-ATPase subunit H//Armadillo/beta-catenin-like repeat//Adaptin N terminal region//HEAT repeat//Proteasome non-ATPase 26S subunit GO:0016192//GO:0006886//GO:0015991//GO:0006606//GO:0043248//GO:0015031 vesicle-mediated transport//intracellular protein transport//ATP hydrolysis coupled proton transport//protein import into nucleus//proteasome assembly//protein transport GO:0005515//GO:0016820//GO:0008565 protein binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances//protein transporter activity GO:0005634//GO:0000221//GO:0030117//GO:0005737 nucleus//vacuolar proton-transporting V-type ATPase, V1 domain//membrane coat//cytoplasm KOG0166 Karyopherin (importin) alpha Cluster-8309.54501 BF_2 99.29 6.33 943 478251178 ENN71654.1 912 1.1e-95 hypothetical protein YQE_11752, partial [Dendroctonus ponderosae] -- -- -- -- -- K18180 COA7, SELRC1, RESA1 cytochrome c oxidase assembly factor 7 http://www.genome.jp/dbget-bin/www_bget?ko:K18180 Q9W5N0 736 1.1e-76 Cytochrome c oxidase assembly factor 7 homolog OS=Drosophila melanogaster GN=CG13865 PE=1 SV=1 PF13176 Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG4014 Uncharacterized conserved protein (contains TPR repeat) Cluster-8309.54502 BF_2 108.72 1.12 4331 642938610 XP_008199864.1 3216 0.0e+00 PREDICTED: protein trachealess [Tribolium castaneum] 820805579 KP147944.1 572 0 Leptinotarsa decemlineata trachealess mRNA, complete cds K09098 NPAS1_3 neuronal PAS domain-containing protein 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K09098 Q8IXF0 1104 1.1e-118 Neuronal PAS domain-containing protein 3 OS=Homo sapiens GN=NPAS3 PE=2 SV=1 PF00989//PF00010//PF04551//PF08447 PAS fold//Helix-loop-helix DNA-binding domain//GcpE protein//PAS fold GO:0055114//GO:0016114//GO:0006355 oxidation-reduction process//terpenoid biosynthetic process//regulation of transcription, DNA-templated GO:0046983//GO:0005515//GO:0046429 protein dimerization activity//protein binding//4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity -- -- -- -- Cluster-8309.54504 BF_2 196.03 2.28 3883 642918532 XP_008191511.1 676 1.0e-67 PREDICTED: microcephalin [Tribolium castaneum] -- -- -- -- -- K19403 MCPH1 microcephalin http://www.genome.jp/dbget-bin/www_bget?ko:K19403 P61590 331 4.3e-29 Microcephalin OS=Colobus guereza GN=MCPH1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54513 BF_2 19.00 0.53 1786 758213862 AJO62244.1 1724 1.4e-189 chemosensory ionotropic receptor IR6 [Tenebrio molitor] -- -- -- -- -- K05313 GRIN glutamate receptor, ionotropic, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05313 P42264 168 1.6e-10 Glutamate receptor ionotropic, kainate 3 OS=Rattus norvegicus GN=Grik3 PE=1 SV=1 PF10613 Ligated ion channel L-glutamate- and glycine-binding site GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane KOG1052 Glutamate-gated kainate-type ion channel receptor subunit GluR5 and related subunits Cluster-8309.54514 BF_2 87.40 1.34 3021 189235122 XP_001811652.1 3243 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 510 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1936 2.6e-215 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856//PF01496//PF05602 SET domain//V-type ATPase 116kDa subunit family//Cleft lip and palate transmembrane protein 1 (CLPTM1) GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0003682//GO:0015078//GO:0005515 chromatin binding//hydrogen ion transmembrane transporter activity//protein binding GO:0033179//GO:0016021//GO:0000785 proton-transporting V-type ATPase, V0 domain//integral component of membrane//chromatin KOG1079 Transcriptional repressor EZH1 Cluster-8309.54515 BF_2 0.39 0.31 333 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54516 BF_2 47.70 1.92 1329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54517 BF_2 107.49 5.28 1139 449083364 NP_001263355.1 776 7.7e-80 dehydrogenase/reductase SDR family member 4 [Tribolium castaneum]>gi|270003836|gb|EFA00284.1| hypothetical protein TcasGA2_TC003117 [Tribolium castaneum] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 568 4.2e-57 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF00106//PF02737//PF01370 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0006631//GO:0006568//GO:0006554//GO:0006552//GO:0055114//GO:0006574//GO:0006550//GO:0018874//GO:0006633//GO:0008152 fatty acid metabolic process//tryptophan metabolic process//lysine catabolic process//leucine catabolic process//oxidation-reduction process//valine catabolic process//isoleucine catabolic process//benzoate metabolic process//fatty acid biosynthetic process//metabolic process GO:0003857//GO:0050662//GO:0003824//GO:0016491 3-hydroxyacyl-CoA dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.54518 BF_2 30.00 0.53 2634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54522 BF_2 42.28 2.40 1023 642938512 XP_008195463.1 612 7.2e-61 PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum]>gi|642938514|ref|XP_008195504.1| PREDICTED: hexaprenyldihydroxybenzoate methyltransferase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K00591 COQ3 polyprenyldihydroxybenzoate methyltransferase / 3-demethylubiquinol 3-O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00591 Q63159 430 3.8e-41 Ubiquinone biosynthesis O-methyltransferase, mitochondrial OS=Rattus norvegicus GN=Coq3 PE=2 SV=2 PF08241 Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG1270 Methyltransferases Cluster-8309.54525 BF_2 35.51 0.61 2732 91077680 XP_974637.1 1934 9.8e-214 PREDICTED: pre-mRNA-splicing factor Slu7 [Tribolium castaneum]>gi|270001533|gb|EEZ97980.1| hypothetical protein TcasGA2_TC000375 [Tribolium castaneum] 762095952 XM_011432193.1 51 5.50872e-15 PREDICTED: Crassostrea gigas pre-mRNA-splicing factor SLU7-like (LOC105330483), transcript variant X2, mRNA K12819 SLU7 pre-mRNA-processing factor SLU7 http://www.genome.jp/dbget-bin/www_bget?ko:K12819 Q9VAQ7 1403 1.5e-153 Pre-mRNA-splicing factor Slu7 OS=Drosophila melanogaster GN=Slu7 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2560 RNA splicing factor - Slu7p Cluster-8309.54528 BF_2 87.46 0.75 5164 642931184 XP_008196473.1 2454 9.3e-274 PREDICTED: mediator of RNA polymerase II transcription subunit 1 [Tribolium castaneum]>gi|270012110|gb|EFA08558.1| hypothetical protein TcasGA2_TC006213 [Tribolium castaneum] -- -- -- -- -- K15144 MED1 mediator of RNA polymerase II transcription subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15144 Q172G3 1280 5.2e-139 Mediator of RNA polymerase II transcription subunit 1 OS=Aedes aegypti GN=AAEL007402 PE=3 SV=1 PF04810//PF10744 Sec23/Sec24 zinc finger//Mediator of RNA polymerase II transcription subunit 1 GO:0006357//GO:0006888//GO:0006886 regulation of transcription from RNA polymerase II promoter//ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0008270//GO:0001104 zinc ion binding//RNA polymerase II transcription cofactor activity GO:0030127//GO:0016592 COPII vesicle coat//mediator complex -- -- Cluster-8309.54532 BF_2 5.00 1.44 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02229 Transcriptional Coactivator p15 (PC4) GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003713 DNA binding//transcription coactivator activity GO:0005667 transcription factor complex -- -- Cluster-8309.54535 BF_2 61.00 0.55 4941 270014342 EFA10790.1 2844 0.0e+00 ret oncogene [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 G3V9H8 956 1.8e-101 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Rattus norvegicus GN=Ret PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.54539 BF_2 25.31 0.56 2185 478251603 ENN72065.1 1404 2.2e-152 hypothetical protein YQE_11351 [Dendroctonus ponderosae]>gi|546674287|gb|ERL85698.1| hypothetical protein D910_03113 [Dendroctonus ponderosae] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q9QXL7 838 3.9e-88 Nucleoside diphosphate kinase 7 OS=Rattus norvegicus GN=Nme7 PE=1 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006144//GO:0006183//GO:0006228//GO:0006165//GO:0006241//GO:0006206 purine nucleobase metabolic process//GTP biosynthetic process//UTP biosynthetic process//nucleoside diphosphate phosphorylation//CTP biosynthetic process//pyrimidine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.54543 BF_2 67.00 0.48 6168 642924926 XP_008194100.1 2756 1.1e-308 PREDICTED: low affinity cationic amino acid transporter 2 [Tribolium castaneum]>gi|270008027|gb|EFA04475.1| hypothetical protein TcasGA2_TC014779 [Tribolium castaneum] 642924925 XM_008195878.1 40 1.6323e-08 PREDICTED: Tribolium castaneum low affinity cationic amino acid transporter 2 (LOC100142535), mRNA K13871 SLC7A14 solute carrier family 7 (cationic amino acid transporter), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K13871 Q8BXR1 922 2.0e-97 Probable cationic amino acid transporter OS=Mus musculus GN=Slc7a14 PE=1 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0006810//GO:0055085//GO:0003333//GO:0006865 transport//transmembrane transport//amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.54545 BF_2 34.70 0.61 2657 270011563 EFA08011.1 491 2.0e-46 hypothetical protein TcasGA2_TC005600 [Tribolium castaneum] 571568585 XM_006565036.1 36 1.1683e-06 PREDICTED: Apis mellifera uncharacterized LOC724120 (LOC724120), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54547 BF_2 231.79 2.16 4773 478251175 ENN71651.1 1844 4.7e-203 hypothetical protein YQE_11749, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2N4 902 3.3e-95 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- KOG4597 Serine proteinase inhibitor (KU family) with thrombospondin repeats Cluster-8309.54548 BF_2 54.10 0.92 2753 328699094 XP_003240827.1 1053 1.4e-111 PREDICTED: uncharacterized protein LOC100571979 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF00628//PF05225 DDE superfamily endonuclease//PHD-finger//helix-turn-helix, Psq domain -- -- GO:0005515//GO:0003676//GO:0003677 protein binding//nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.54549 BF_2 19.88 0.98 1140 642935340 XP_968306.2 570 6.0e-56 PREDICTED: kelch domain-containing protein 10 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1ZB86 369 5.0e-34 Kelch domain-containing protein 10 homolog OS=Drosophila melanogaster GN=slim PE=1 SV=1 PF01344//PF00892//PF09187//PF07646 Kelch motif//EamA-like transporter family//Domain of unknown function(DUF1950)//Kelch motif GO:0044030 regulation of DNA methylation GO:0005515 protein binding GO:0016020//GO:0005634//GO:0016021 membrane//nucleus//integral component of membrane -- -- Cluster-8309.54550 BF_2 12.35 0.88 876 332375186 AEE62734.1 305 2.4e-25 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344//PF07646 Kelch motif//Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54551 BF_2 12.80 0.82 938 91094511 XP_971832.1 572 2.9e-56 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] -- -- -- -- -- K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q9Z2X1 425 1.3e-40 Heterogeneous nuclear ribonucleoprotein F OS=Mus musculus GN=Hnrnpf PE=1 SV=3 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.54552 BF_2 36.80 0.87 2050 642920057 XP_008192187.1 1719 6.2e-189 PREDICTED: mitochondrial import inner membrane translocase subunit TIM44 [Tribolium castaneum] -- -- -- -- -- K17804 TIM44 mitochondrial import inner membrane translocase subunit TIM44 http://www.genome.jp/dbget-bin/www_bget?ko:K17804 O43615 1037 3.1e-111 Mitochondrial import inner membrane translocase subunit TIM44 OS=Homo sapiens GN=TIMM44 PE=1 SV=2 PF07926//PF05478//PF08336//PF07464//PF02932 TPR/MLP1/MLP2-like protein//Prominin//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Apolipophorin-III precursor (apoLp-III)//Neurotransmitter-gated ion-channel transmembrane region GO:0006525//GO:0018401//GO:0006869//GO:0006560//GO:0006606//GO:0055114//GO:0006811 arginine metabolic process//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//lipid transport//proline metabolic process//protein import into nucleus//oxidation-reduction process//ion transport GO:0004656//GO:0008289//GO:0016702 procollagen-proline 4-dioxygenase activity//lipid binding//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0016021//GO:0005783//GO:0005576//GO:0016020 integral component of membrane//endoplasmic reticulum//extracellular region//membrane KOG2580 Mitochondrial import inner membrane translocase, subunit TIM44 Cluster-8309.54553 BF_2 5.00 3.10 350 728417900 AIY68351.1 183 1.4e-11 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54554 BF_2 36.57 1.07 1723 189236906 XP_001809986.1 771 4.4e-79 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 E9PTT0 390 2.8e-36 Palmitoyltransferase ZDHHC17 OS=Rattus norvegicus GN=Zdhhc17 PE=1 SV=1 PF01529 DHHC palmitoyltransferase -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.54555 BF_2 129.13 4.96 1377 478251437 ENN71902.1 503 4.2e-48 hypothetical protein YQE_11439, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54563 BF_2 35.20 0.32 4958 546678030 ERL88754.1 994 1.8e-104 hypothetical protein D910_06136 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5E9J6 347 7.7e-31 E3 ubiquitin-protein ligase RNF34 OS=Bos taurus GN=RNF34 PE=2 SV=1 PF13639//PF15323//PF12906//PF14634//PF01363 Ring finger domain//Developmental protein//RING-variant domain//zinc-RING finger domain//FYVE zinc finger GO:0048598 embryonic morphogenesis GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0072669 tRNA-splicing ligase complex -- -- Cluster-8309.54566 BF_2 22.94 2.25 714 817321396 XP_012331387.1 311 4.0e-26 PREDICTED: fibroblast growth factor receptor 1 isoform X6 [Aotus nancymaae]>gi|817321398|ref|XP_012331388.1| PREDICTED: fibroblast growth factor receptor 1 isoform X6 [Aotus nancymaae] 188219627 NG_007729.1 714 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P11362 311 1.6e-27 Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8309.5457 BF_2 37.60 0.88 2072 642937575 XP_008199104.1 489 2.7e-46 PREDICTED: uncharacterized protein LOC103314532 [Tribolium castaneum]>gi|270001210|gb|EEZ97657.1| hypothetical protein TcasGA2_TC016201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF00036 THAP domain//EF hand -- -- GO:0003676//GO:0005509 nucleic acid binding//calcium ion binding -- -- -- -- Cluster-8309.54576 BF_2 38.00 0.59 2998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54578 BF_2 7.92 1.09 591 478259929 ENN79731.1 478 1.4e-45 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 257 2.5e-21 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF09243 Mitochondrial small ribosomal subunit Rsm22 GO:0006412 translation GO:0008168 methyltransferase activity -- -- KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.54582 BF_2 39.72 0.66 2801 759178516 XP_011378476.1 220 5.6e-15 PREDICTED: targeting protein for Xklp2 [Pteropus vampyrus] -- -- -- -- -- -- -- -- -- Q5RAF2 182 5.9e-12 Targeting protein for Xklp2 OS=Pongo abelii GN=TPX2 PE=2 SV=1 PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.54585 BF_2 1.00 0.47 373 189235393 XP_001810875.1 225 2.0e-16 PREDICTED: targeting protein for Xklp2 [Tribolium castaneum]>gi|270003583|gb|EFA00031.1| hypothetical protein TcasGA2_TC002838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54587 BF_2 2.00 1.53 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54588 BF_2 26.20 0.42 2877 189235393 XP_001810875.1 455 3.2e-42 PREDICTED: targeting protein for Xklp2 [Tribolium castaneum]>gi|270003583|gb|EFA00031.1| hypothetical protein TcasGA2_TC002838 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- E2RYF8 271 2.9e-22 Targeting protein for Xklp2 homolog OS=Patiria pectinifera GN=TPX2 PE=2 SV=1 PF07850 Renin receptor-like protein GO:0007165 signal transduction GO:0004872 receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.54591 BF_2 19.41 0.39 2356 270014462 EFA10910.1 267 1.7e-20 hypothetical protein TcasGA2_TC001736 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54594 BF_2 37.00 0.36 4607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54595 BF_2 106.65 5.36 1119 642929450 XP_008195846.1 904 1.1e-94 PREDICTED: serine/threonine-protein kinase D3 isoform X2 [Tribolium castaneum] -- -- -- -- -- K06070 PKD protein kinase D http://www.genome.jp/dbget-bin/www_bget?ko:K06070 Q8K1Y2 462 8.0e-45 Serine/threonine-protein kinase D3 OS=Mus musculus GN=Prkd3 PE=1 SV=1 PF00628//PF05191//PF00130 PHD-finger//Adenylate kinase, active site lid//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006144//GO:0046034//GO:0035556 purine nucleobase metabolic process//ATP metabolic process//intracellular signal transduction GO:0005515//GO:0004017 protein binding//adenylate kinase activity -- -- KOG4236 Serine/threonine protein kinase PKC mu/PKD and related proteins Cluster-8309.54596 BF_2 735.01 8.04 4110 478255815 ENN76023.1 2410 9.4e-269 hypothetical protein YQE_07399, partial [Dendroctonus ponderosae] -- -- -- -- -- K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q9EP53 482 1.4e-46 Hamartin OS=Mus musculus GN=Tsc1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4674 Uncharacterized conserved coiled-coil protein Cluster-8309.54597 BF_2 20.00 0.98 1137 270010513 EFA06961.1 502 4.5e-48 hypothetical protein TcasGA2_TC009919 [Tribolium castaneum] -- -- -- -- -- K15199 GTF3C1 general transcription factor 3C polypeptide 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15199 Q12789 323 1.1e-28 General transcription factor 3C polypeptide 1 OS=Homo sapiens GN=GTF3C1 PE=1 SV=4 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54601 BF_2 3.00 0.52 529 861587829 KMQ82562.1 282 6.9e-23 histone-lysine n-methyltransferase setmar-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54602 BF_2 184.38 1.40 5807 642929357 XP_008195802.1 2106 2.4e-233 PREDICTED: uncharacterized protein LOC100142360 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q12789 770 8.0e-80 General transcription factor 3C polypeptide 1 OS=Homo sapiens GN=GTF3C1 PE=1 SV=4 PF04186 FxsA cytoplasmic membrane protein -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.54608 BF_2 162.17 1.09 6487 91091098 XP_968555.1 1977 2.4e-218 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- K05684 ABCG8 ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2) http://www.genome.jp/dbget-bin/www_bget?ko:K05684 Q99PE7 367 4.8e-33 ATP-binding cassette sub-family G member 5 OS=Rattus norvegicus GN=Abcg5 PE=2 SV=3 PF01061//PF06422//PF00005//PF08352 ABC-2 type transporter//CDR ABC transporter//ABC transporter//Oligopeptide/dipeptide transporter, C-terminal region GO:0015833//GO:0006810//GO:0006200 peptide transport//transport//obsolete ATP catabolic process GO:0042626//GO:0016887//GO:0000166//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//ATPase activity//nucleotide binding//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.5461 BF_2 2.00 2.69 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54610 BF_2 159.06 1.14 6102 91091098 XP_968555.1 1661 9.9e-182 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- K05684 ABCG8 ATP-binding cassette, subfamily G (WHITE), member 8 (sterolin 2) http://www.genome.jp/dbget-bin/www_bget?ko:K05684 Q9H221 414 1.6e-38 ATP-binding cassette sub-family G member 8 OS=Homo sapiens GN=ABCG8 PE=1 SV=1 PF01061//PF06422//PF00005 ABC-2 type transporter//CDR ABC transporter//ABC transporter GO:0006200//GO:0006810 obsolete ATP catabolic process//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0016020 integral component of membrane//membrane KOG0061 Transporter, ABC superfamily (Breast cancer resistance protein) Cluster-8309.54613 BF_2 33.30 1.25 1401 189240973 XP_967534.2 1507 1.6e-164 PREDICTED: TNF receptor-associated factor 4 isoform X1 [Tribolium castaneum] 746832798 XM_011061811.1 84 1.26275e-33 PREDICTED: Acromyrmex echinatior TNF receptor-associated factor 4 (LOC105149400), transcript variant X4, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 796 1.9e-83 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF15965//PF02176//PF03145 TRAF-like zinc-finger//TRAF-type zinc finger//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.54614 BF_2 322.00 9.91 1646 -- -- -- -- -- 284431769 FJ940204.1 1646 0 Oryza sativa Japonica Group clone KCS307D06 glutelin mRNA, complete cds -- -- -- -- P14614 2421 8.2e-272 Glutelin type-B 4 OS=Oryza sativa subsp. japonica GN=GLUB4 PE=1 SV=1 PF03079//PF00190 ARD/ARD' family//Cupin GO:0055114 oxidation-reduction process GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity -- -- -- -- Cluster-8309.54615 BF_2 92.43 0.69 5910 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54616 BF_2 1272.83 10.86 5188 478262931 ENN81354.1 5338 0.0e+00 hypothetical protein YQE_02244, partial [Dendroctonus ponderosae]>gi|546674076|gb|ERL85556.1| hypothetical protein D910_02975 [Dendroctonus ponderosae] 827549416 XM_004927285.2 162 2.07848e-76 PREDICTED: Bombyx mori tankyrase (LOC101740141), mRNA K10799 TNKS tankyrase http://www.genome.jp/dbget-bin/www_bget?ko:K10799 Q9VBP3 4501 0.0e+00 Tankyrase OS=Drosophila melanogaster GN=Tnks PE=1 SV=1 PF00023//PF00322//PF13606//PF00644//PF00536//PF07647 Ankyrin repeat//Endothelin family//Ankyrin repeat//Poly(ADP-ribose) polymerase catalytic domain//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0019229 regulation of vasoconstriction GO:0003950//GO:0005515 NAD+ ADP-ribosyltransferase activity//protein binding GO:0005576 extracellular region KOG4177 Ankyrin Cluster-8309.54621 BF_2 35.63 0.48 3423 332375999 AEE63140.1 1341 7.1e-145 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6DGR4 833 2.3e-87 Protein HGH1 homolog OS=Danio rerio GN=hgh1 PE=2 SV=1 PF01080//PF05485 Presenilin//THAP domain -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2973 Uncharacterized conserved protein Cluster-8309.54622 BF_2 21.89 0.58 1861 478256893 ENN77062.1 359 2.8e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 2.9e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF13912//PF05485//PF00096//PF13465//PF07975 C2H2-type zinc finger//THAP domain//Zinc finger, C2H2 type//Zinc-finger double domain//TFIIH C1-like domain GO:0006281 DNA repair GO:0003676//GO:0008270//GO:0046872 nucleic acid binding//zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.54626 BF_2 3.00 26.04 237 -- -- -- -- -- 56968026 AY859572.1 61 1.15186e-21 Eremobates sp. JM-2004 5.8S ribosomal RNA gene, partial sequence; internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54628 BF_2 12.42 0.41 1560 576249490 AHH29251.1 720 3.3e-73 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05048 SLC6A15S solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20 http://www.genome.jp/dbget-bin/www_bget?ko:K05048 Q9VR07 521 1.6e-51 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF13333//PF00209 Integrase core domain//Sodium:neurotransmitter symporter family GO:0015074//GO:0006812//GO:0006836 DNA integration//cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.5463 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54631 BF_2 47.52 0.79 2816 91076832 XP_974636.1 2502 1.4e-279 PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|642913069|ref|XP_008201376.1| PREDICTED: mitogen-activated protein kinase kinase kinase 4 [Tribolium castaneum]>gi|270001936|gb|EEZ98383.1| hypothetical protein TcasGA2_TC000847 [Tribolium castaneum] -- -- -- -- -- K04428 MAP3K4, MEKK4 mitogen-activated protein kinase kinase kinase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04428 O08648 296 3.6e-25 Mitogen-activated protein kinase kinase kinase 4 OS=Mus musculus GN=Map3k4 PE=1 SV=2 -- -- -- -- GO:0004672//GO:0000166 protein kinase activity//nucleotide binding -- -- -- -- Cluster-8309.54633 BF_2 23.32 0.77 1555 674034550 XP_008839429.1 531 2.7e-51 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 420-like [Nannospalax galili] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q32M78 499 5.7e-49 Zinc finger protein 699 OS=Homo sapiens GN=ZNF699 PE=1 SV=1 PF07975//PF07934//PF13465//PF03326//PF16622//PF13912//PF00096//PF07776 TFIIH C1-like domain//8-oxoguanine DNA glycosylase, N-terminal domain//Zinc-finger double domain//Herpesvirus transcription activation factor (transactivator)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) GO:0006308//GO:0006289//GO:0006285//GO:0006355//GO:0006281 DNA catabolic process//nucleotide-excision repair//base-excision repair, AP site formation//regulation of transcription, DNA-templated//DNA repair GO:0046872//GO:0003684//GO:0008270//GO:0008534 metal ion binding//damaged DNA binding//zinc ion binding//oxidized purine nucleobase lesion DNA N-glycosylase activity GO:0005634 nucleus -- -- Cluster-8309.54634 BF_2 42.76 0.68 2922 642930253 XP_008196317.1 1147 1.9e-122 PREDICTED: lachesin-like [Tribolium castaneum]>gi|642930255|ref|XP_008196318.1| PREDICTED: lachesin-like [Tribolium castaneum]>gi|642930257|ref|XP_008196319.1| PREDICTED: lachesin-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54637 BF_2 8.00 0.67 787 642913740 XP_008201142.1 345 5.0e-30 PREDICTED: serine/threonine-protein kinase PLK4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q64702 136 3.6e-07 Serine/threonine-protein kinase PLK4 OS=Mus musculus GN=Plk4 PE=1 SV=2 PF00659 POLO box duplicated region -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54643 BF_2 3.00 1.28 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54644 BF_2 659.00 17.16 1894 546678777 ERL89329.1 752 7.8e-77 hypothetical protein D910_06701 [Dendroctonus ponderosae] -- -- -- -- -- K19511 PXDN, VPO1 peroxidase http://www.genome.jp/dbget-bin/www_bget?ko:K19511 Q6WRI0 239 9.8e-19 Immunoglobulin superfamily member 10 OS=Homo sapiens GN=IGSF10 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.54648 BF_2 3.00 0.54 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54650 BF_2 9.30 0.85 745 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54653 BF_2 153.23 2.49 2858 270005700 EFA02148.1 305 8.0e-25 hypothetical protein TcasGA2_TC007800 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01484//PF10473 Nematode cuticle collagen N-terminal domain//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 -- -- GO:0042302//GO:0008134//GO:0045502//GO:0042803 structural constituent of cuticle//transcription factor binding//dynein binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.54654 BF_2 167.95 1.38 5369 91082805 XP_968057.1 1207 3.8e-129 PREDICTED: beta-1,3-galactosyltransferase 6 [Tribolium castaneum] -- -- -- -- -- K00734 B3GALT6 galactosylxylosylprotein 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00734 Q9N491 438 2.3e-41 Beta-1,3-galactosyltransferase sqv-2 OS=Caenorhabditis elegans GN=sqv-2 PE=2 SV=1 PF01762 Galactosyltransferase GO:0006486 protein glycosylation GO:0008378 galactosyltransferase activity GO:0016020 membrane KOG2288 Galactosyltransferases Cluster-8309.54657 BF_2 50.33 2.38 1173 91079546 XP_971272.1 196 1.4e-12 PREDICTED: uncharacterized protein LOC659913 [Tribolium castaneum]>gi|270003419|gb|EEZ99866.1| hypothetical protein TcasGA2_TC002648 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03505//PF10717 Clostridium enterotoxin//Occlusion-derived virus envelope protein ODV-E18 GO:0009405 pathogenesis -- -- GO:0005576//GO:0019031 extracellular region//viral envelope -- -- Cluster-8309.54660 BF_2 13.78 0.64 1194 91091562 XP_967054.1 556 2.6e-54 PREDICTED: mRNA turnover protein 4 homolog [Tribolium castaneum]>gi|270000914|gb|EEZ97361.1| hypothetical protein TcasGA2_TC011183 [Tribolium castaneum] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9D0I8 443 1.4e-42 mRNA turnover protein 4 homolog OS=Mus musculus GN=Mrto4 PE=2 SV=1 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0030529//GO:0005622 intracellular ribonucleoprotein complex//intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.54662 BF_2 170.00 3.38 2391 270004127 EFA00575.1 1563 8.9e-171 hypothetical protein TcasGA2_TC003445 [Tribolium castaneum] -- -- -- -- -- K15691 RFWD3 E3 ubiquitin-protein ligase RFWD3 http://www.genome.jp/dbget-bin/www_bget?ko:K15691 Q8CIK8 580 3.6e-58 E3 ubiquitin-protein ligase RFWD3 OS=Mus musculus GN=Rfwd3 PE=2 SV=1 PF11789//PF12678//PF17123//PF14634//PF00097//PF13639//PF12861//PF01363//PF00400 Zinc-finger of the MIZ type in Nse subunit//RING-H2 zinc finger//RING-like zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ring finger domain//Anaphase-promoting complex subunit 11 RING-H2 finger//FYVE zinc finger//WD domain, G-beta repeat GO:0016567 protein ubiquitination GO:0004842//GO:0005515//GO:0046872//GO:0008270 ubiquitin-protein transferase activity//protein binding//metal ion binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG1645 RING-finger-containing E3 ubiquitin ligase Cluster-8309.54666 BF_2 141.95 1.37 4617 642918773 XP_008191578.1 4387 0.0e+00 PREDICTED: calpain-D-like isoform X2 [Tribolium castaneum] 194768179 XM_001966155.1 202 1.07363e-98 Drosophila ananassae GF19541 (Dana\GF19541), mRNA K08582 CAPN15 calpain-15 http://www.genome.jp/dbget-bin/www_bget?ko:K08582 P27398 2414 1.5e-270 Calpain-D OS=Drosophila melanogaster GN=sol PE=1 SV=2 PF00641//PF00648 Zn-finger in Ran binding protein and others//Calpain family cysteine protease GO:0006508 proteolysis GO:0004198//GO:0008270 calcium-dependent cysteine-type endopeptidase activity//zinc ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.54669 BF_2 10.00 0.81 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54671 BF_2 6.00 0.50 794 -- -- -- -- -- 642922719 XM_008195074.1 82 9.09101e-33 PREDICTED: Tribolium castaneum LIM domain transcription factor LMO4.1 (LOC661046), transcript variant X5, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54672 BF_2 8.38 0.63 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54677 BF_2 43.89 0.41 4815 642933730 XP_008197339.1 4432 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 6.7e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.5468 BF_2 21.00 0.47 2164 546675479 ERL86664.1 320 1.1e-26 hypothetical protein D910_04070 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54682 BF_2 1.00 1.59 295 332374576 AEE62429.1 192 1.0e-12 unknown [Dendroctonus ponderosae]>gi|478259055|gb|ENN78998.1| hypothetical protein YQE_04549, partial [Dendroctonus ponderosae]>gi|546678369|gb|ERL89002.1| hypothetical protein D910_06380 [Dendroctonus ponderosae] -- -- -- -- -- K17095 ANXA7_11 annexin A7/11 http://www.genome.jp/dbget-bin/www_bget?ko:K17095 P22464 155 8.4e-10 Annexin B9 OS=Drosophila melanogaster GN=AnxB9 PE=2 SV=2 PF00191 Annexin -- -- GO:0005544//GO:0005509 calcium-dependent phospholipid binding//calcium ion binding -- -- KOG0819 Annexin Cluster-8309.54686 BF_2 104.62 0.72 6363 91083069 XP_967587.1 2909 0.0e+00 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q0KI50 1792 2.7e-198 Dystrophin, isoform D OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF14641//PF08115//PF00569//PF04632//PF16473//PF00397//PF04111//PF04977//PF08826//PF11365//PF11802//PF02183//PF02601//PF10473//PF09177 Helix-turn-helix DNA-binding domain of SPT6//SFI toxin family//Zinc finger, ZZ type//Fusaric acid resistance protein family//Domain of unknown function (DUF5051)//WW domain//Autophagy protein Apg6//Septum formation initiator//DMPK coiled coil domain like//Protein of unknown function (DUF3166)//Centromere-associated protein K//Homeobox associated leucine zipper//Exonuclease VII, large subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal GO:0010506//GO:0016310//GO:0048193//GO:0006810//GO:0006468//GO:0009069//GO:0006914//GO:0009405//GO:0007049//GO:0006355//GO:0006308 regulation of autophagy//phosphorylation//Golgi vesicle transport//transport//protein phosphorylation//serine family amino acid metabolic process//autophagy//pathogenesis//cell cycle//regulation of transcription, DNA-templated//DNA catabolic process GO:0008134//GO:0045502//GO:0005524//GO:0004674//GO:0003700//GO:0003676//GO:0005509//GO:0043565//GO:0008270//GO:0005515//GO:0008855//GO:0003677//GO:0042803 transcription factor binding//dynein binding//ATP binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//nucleic acid binding//calcium ion binding//sequence-specific DNA binding//zinc ion binding//protein binding//exodeoxyribonuclease VII activity//DNA binding//protein homodimerization activity GO:0005615//GO:0009318//GO:0005667//GO:0030286//GO:0005886//GO:0005634//GO:0016020//GO:0005576 extracellular space//exodeoxyribonuclease VII complex//transcription factor complex//dynein complex//plasma membrane//nucleus//membrane//extracellular region -- -- Cluster-8309.54687 BF_2 87.68 0.92 4270 91083069 XP_967587.1 2481 5.7e-277 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q7YU29 1702 5.0e-188 Dystrophin, isoform E OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF02183//PF02601//PF04977//PF00569//PF10473//PF01166//PF07716//PF11365//PF11802//PF08826//PF04111//PF00397//PF16473//PF00170//PF08115//PF06005//PF14641 Homeobox associated leucine zipper//Exonuclease VII, large subunit//Septum formation initiator//Zinc finger, ZZ type//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TSC-22/dip/bun family//Basic region leucine zipper//Protein of unknown function (DUF3166)//Centromere-associated protein K//DMPK coiled coil domain like//Autophagy protein Apg6//WW domain//Domain of unknown function (DUF5051)//bZIP transcription factor//SFI toxin family//Protein of unknown function (DUF904)//Helix-turn-helix DNA-binding domain of SPT6 GO:0006355//GO:0007049//GO:0010506//GO:0009405//GO:0006914//GO:0009069//GO:0006468//GO:0043093//GO:0000917//GO:0006308//GO:0016310 regulation of transcription, DNA-templated//cell cycle//regulation of autophagy//pathogenesis//autophagy//serine family amino acid metabolic process//protein phosphorylation//FtsZ-dependent cytokinesis//barrier septum assembly//DNA catabolic process//phosphorylation GO:0008270//GO:0043565//GO:0004674//GO:0003700//GO:0005524//GO:0045502//GO:0008134//GO:0003676//GO:0042803//GO:0005509//GO:0003677//GO:0005515//GO:0008855 zinc ion binding//sequence-specific DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding//ATP binding//dynein binding//transcription factor binding//nucleic acid binding//protein homodimerization activity//calcium ion binding//DNA binding//protein binding//exodeoxyribonuclease VII activity GO:0009318//GO:0005737//GO:0005615//GO:0005576//GO:0030286//GO:0005634//GO:0005667 exodeoxyribonuclease VII complex//cytoplasm//extracellular space//extracellular region//dynein complex//nucleus//transcription factor complex -- -- Cluster-8309.54688 BF_2 50.97 0.50 4522 91083069 XP_967587.1 2488 9.3e-278 PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923495|ref|XP_008193533.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|642923497|ref|XP_008193534.1| PREDICTED: dystrophin, isoform B [Tribolium castaneum]>gi|270007008|gb|EFA03456.1| hypothetical protein TcasGA2_TC013449 [Tribolium castaneum] -- -- -- -- -- K10366 DMD dystrophin http://www.genome.jp/dbget-bin/www_bget?ko:K10366 Q9VDW3 1708 1.1e-188 Dystrophin, isoform B OS=Drosophila melanogaster GN=Dys PE=1 SV=3 PF08826//PF11365//PF11802//PF07716//PF01166//PF10473//PF14641//PF06005//PF00170//PF08115//PF00397//PF16473//PF04111//PF02183//PF02601//PF00569//PF04977 DMPK coiled coil domain like//Protein of unknown function (DUF3166)//Centromere-associated protein K//Basic region leucine zipper//TSC-22/dip/bun family//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Helix-turn-helix DNA-binding domain of SPT6//Protein of unknown function (DUF904)//bZIP transcription factor//SFI toxin family//WW domain//Domain of unknown function (DUF5051)//Autophagy protein Apg6//Homeobox associated leucine zipper//Exonuclease VII, large subunit//Zinc finger, ZZ type//Septum formation initiator GO:0009069//GO:0006914//GO:0006468//GO:0010506//GO:0009405//GO:0007049//GO:0006355//GO:0016310//GO:0006308//GO:0043093//GO:0000917 serine family amino acid metabolic process//autophagy//protein phosphorylation//regulation of autophagy//pathogenesis//cell cycle//regulation of transcription, DNA-templated//phosphorylation//DNA catabolic process//FtsZ-dependent cytokinesis//barrier septum assembly GO:0045502//GO:0008134//GO:0005524//GO:0003700//GO:0004674//GO:0008270//GO:0043565//GO:0008855//GO:0005515//GO:0003677//GO:0042803//GO:0005509//GO:0003676 dynein binding//transcription factor binding//ATP binding//transcription factor activity, sequence-specific DNA binding//protein serine/threonine kinase activity//zinc ion binding//sequence-specific DNA binding//exodeoxyribonuclease VII activity//protein binding//DNA binding//protein homodimerization activity//calcium ion binding//nucleic acid binding GO:0005615//GO:0005737//GO:0009318//GO:0005667//GO:0005634//GO:0030286//GO:0005576 extracellular space//cytoplasm//exodeoxyribonuclease VII complex//transcription factor complex//nucleus//dynein complex//extracellular region -- -- Cluster-8309.5469 BF_2 3.00 0.57 509 795248736 XP_011854478.1 658 1.7e-66 PREDICTED: tubulin beta chain isoform X1 [Mandrillus leucophaeus] 649115485 KJ895812.1 357 0 Synthetic construct Homo sapiens clone ccsbBroadEn_05206 TUBB gene, encodes complete protein K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 Q5R943 658 6.8e-68 Tubulin beta chain OS=Pongo abelii GN=TUBB PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1375 Beta tubulin Cluster-8309.54691 BF_2 71.18 1.00 3252 642927423 XP_008195266.1 1097 1.3e-116 PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum]>gi|642927425|ref|XP_008195267.1| PREDICTED: uncharacterized protein LOC103313545 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF16622 Zinc finger, C2H2 type//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.54694 BF_2 67.75 0.98 3180 642926208 XP_008194830.1 1578 2.2e-172 PREDICTED: uncharacterized protein LOC662086 isoform X2 [Tribolium castaneum] 347967374 XM_003436013.1 97 1.72407e-40 Anopheles gambiae str. PEST AGAP002199-PB (AgaP_AGAP002199) mRNA, complete cds -- -- -- -- -- -- -- -- PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54695 BF_2 263.25 3.01 3944 270009021 EFA05469.1 2230 6.7e-248 hypothetical protein TcasGA2_TC015652 [Tribolium castaneum] 347967374 XM_003436013.1 97 2.14302e-40 Anopheles gambiae str. PEST AGAP002199-PB (AgaP_AGAP002199) mRNA, complete cds -- -- -- -- -- -- -- -- PF14719 Phosphotyrosine interaction domain (PTB/PID) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54696 BF_2 47.00 2.40 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54699 BF_2 48.02 2.42 1118 189242304 XP_001808377.1 640 4.5e-64 PREDICTED: uncharacterized protein LOC100141613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54701 BF_2 3.00 0.50 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54702 BF_2 256.67 2.97 3897 642913983 XP_008201501.1 2263 9.9e-252 PREDICTED: probable ATP-dependent RNA helicase DDX56 [Tribolium castaneum]>gi|270002128|gb|EEZ98575.1| hypothetical protein TcasGA2_TC001089 [Tribolium castaneum] 642913982 XM_008203279.1 342 1.35214e-176 PREDICTED: Tribolium castaneum probable ATP-dependent RNA helicase DDX56 (LOC655034), mRNA K14810 DDX56, DBP9 ATP-dependent RNA helicase DDX56/DBP9 http://www.genome.jp/dbget-bin/www_bget?ko:K14810 Q3SZ40 1378 1.7e-150 Probable ATP-dependent RNA helicase DDX56 OS=Bos taurus GN=DDX56 PE=2 SV=1 PF04851//PF01484//PF02732//PF07652//PF00270 Type III restriction enzyme, res subunit//Nematode cuticle collagen N-terminal domain//ERCC4 domain//Flavivirus DEAD domain//DEAD/DEAH box helicase GO:0019079 viral genome replication GO:0003676//GO:0004518//GO:0003677//GO:0016787//GO:0005524//GO:0042302//GO:0008026 nucleic acid binding//nuclease activity//DNA binding//hydrolase activity//ATP binding//structural constituent of cuticle//ATP-dependent helicase activity -- -- KOG0346 RNA helicase Cluster-8309.54703 BF_2 144.00 3.37 2075 642938784 XP_008199885.1 1060 1.6e-112 PREDICTED: meiosis-specific nuclear structural protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBA8 579 4.0e-58 Meiosis-specific nuclear structural protein 1 OS=Danio rerio GN=mns1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54708 BF_2 18.38 2.14 647 642922009 XP_008192983.1 180 5.6e-11 PREDICTED: timeless isoform X1 [Tribolium castaneum]>gi|270008196|gb|EFA04644.1| timeless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54709 BF_2 4.00 1.70 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54712 BF_2 59.09 0.34 7642 642932112 XP_008196860.1 3146 0.0e+00 PREDICTED: ABC transporter G family member 14 isoform X1 [Tribolium castaneum] 642932111 XM_008198638.1 779 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA -- -- -- -- Q6WV17 1239 4.4e-134 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF01637//PF05418//PF00005//PF03193//PF00910//PF10662//PF01061//PF01926//PF13304//PF00004//PF00437 Archaeal ATPase//Apovitellenin I (Apo-VLDL-II)//ABC transporter//Protein of unknown function, DUF258//RNA helicase//Ethanolamine utilisation - propanediol utilisation//ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein GO:0006576//GO:0006629//GO:0006810 cellular biogenic amine metabolic process//lipid metabolic process//transport GO:0003723//GO:0005524//GO:0003924//GO:0004857//GO:0016887//GO:0005525//GO:0003724 RNA binding//ATP binding//GTPase activity//enzyme inhibitor activity//ATPase activity//GTP binding//RNA helicase activity GO:0016020//GO:0042627 membrane//chylomicron KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.54713 BF_2 8.05 0.40 1135 642932395 XP_008197093.1 418 2.5e-38 PREDICTED: leucine-rich repeat-containing protein 70-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESY6 127 5.7e-06 Leucine-rich repeat neuronal protein 3 OS=Rattus norvegicus GN=Lrrn3 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.54718 BF_2 13.49 0.50 1422 642925526 XP_008194587.1 238 2.3e-17 PREDICTED: probable low-specificity L-threonine aldolase 2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K01620 ltaE threonine aldolase http://www.genome.jp/dbget-bin/www_bget?ko:K01620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54723 BF_2 9.72 1.41 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54729 BF_2 629.98 8.10 3542 759041178 XP_011329400.1 2003 1.3e-221 PREDICTED: alpha-N-acetylgalactosaminidase isoform X1 [Cerapachys biroi] 195434173 XM_002065042.1 152 5.12333e-71 Drosophila willistoni GK15268 (Dwil\GK15268), mRNA K01204 NAGA alpha-N-acetylgalactosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K01204 Q90744 1145 1.6e-123 Alpha-N-acetylgalactosaminidase OS=Gallus gallus GN=NAGA PE=1 SV=1 PF01340//PF03602//PF05185//PF01209//PF02390//PF08241//PF01728//PF01135//PF05175//PF02065//PF00517//PF16499 Met Apo-repressor, MetJ//Conserved hypothetical protein 95//PRMT5 arginine-N-methyltransferase//ubiE/COQ5 methyltransferase family//Putative methyltransferase//Methyltransferase domain//FtsJ-like methyltransferase//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Melibiase//Retroviral envelope protein//Alpha galactosidase A GO:0031167//GO:0001575//GO:0006464//GO:0046486//GO:0008033//GO:0005975//GO:0006355//GO:0006012//GO:0008152//GO:0046500//GO:0006555//GO:0032259//GO:0006400//GO:0009451//GO:0006479 rRNA methylation//globoside metabolic process//cellular protein modification process//glycerolipid metabolic process//tRNA processing//carbohydrate metabolic process//regulation of transcription, DNA-templated//galactose metabolic process//metabolic process//S-adenosylmethionine metabolic process//methionine metabolic process//methylation//tRNA modification//RNA modification//protein methylation GO:0005198//GO:0004553//GO:0004557//GO:0003700//GO:0008168//GO:0004719//GO:0008176 structural molecule activity//hydrolase activity, hydrolyzing O-glycosyl compounds//alpha-galactosidase activity//transcription factor activity, sequence-specific DNA binding//methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity GO:0005667//GO:0019031 transcription factor complex//viral envelope KOG2366 Alpha-D-galactosidase (melibiase) Cluster-8309.54734 BF_2 8.00 8.08 318 194318496 ACF47636.1 305 8.9e-26 soluble FGFR2 variant 3 [Homo sapiens] 92918934 DQ493927.1 318 2.19332e-164 Homo sapiens fibroblast growth factor receptor 2 (bacteria-expressed kinase, keratinocyte growth factor receptor, craniofacial dysostosis 1, Crouzon syndrome, Pfeiffer syndrome, Jackson-Weiss syndrome) (FGFR2) gene, complete cds K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 229 2.4e-18 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.54735 BF_2 16.17 0.38 2090 478253248 ENN73619.1 686 3.9e-69 hypothetical protein YQE_09866, partial [Dendroctonus ponderosae] -- -- -- -- -- K15277 SLC35B3, PAPST2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 http://www.genome.jp/dbget-bin/www_bget?ko:K15277 Q7Q5D4 522 1.7e-51 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Anopheles gambiae GN=Papst2 PE=3 SV=4 PF08449//PF00892 UAA transporter family//EamA-like transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1582 UDP-galactose transporter related protein Cluster-8309.54737 BF_2 7.86 0.56 873 642913866 XP_008201194.1 317 9.9e-27 PREDICTED: leucine-rich repeat-containing protein C10orf11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H2I8 220 7.2e-17 Leucine-rich repeat-containing protein C10orf11 OS=Homo sapiens GN=C10orf11 PE=1 SV=1 PF02963 Restriction endonuclease EcoRI GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0003677//GO:0009036//GO:0000287 DNA binding//Type II site-specific deoxyribonuclease activity//magnesium ion binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.54738 BF_2 26.32 0.40 3056 270004382 EFA00830.1 641 9.3e-64 hypothetical protein TcasGA2_TC003718 [Tribolium castaneum] -- -- -- -- -- K08731 BIRC5 baculoviral IAP repeat-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K08731 Q5F201 279 3.6e-23 Cilia- and flagella-associated protein 52 OS=Mus musculus GN=Cfap52 PE=2 SV=1 PF07967 C3HC zinc finger-like -- -- GO:0008270 zinc ion binding GO:0005634 nucleus KOG1101 Apoptosis inhibitor IAP1 and related BIR domain proteins Cluster-8309.54742 BF_2 78.48 2.67 1518 546683069 ERL92930.1 479 2.8e-45 hypothetical protein D910_10235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JL89 209 2.4e-15 Ninjurin-2 OS=Mus musculus GN=Ninj2 PE=2 SV=1 PF04923//PF01545//PF10192//PF02990 Ninjurin//Cation efflux family//Rhodopsin-like GPCR transmembrane domain//Endomembrane protein 70 GO:0007155//GO:0007186//GO:0006812//GO:0019236//GO:0055085//GO:0042246 cell adhesion//G-protein coupled receptor signaling pathway//cation transport//response to pheromone//transmembrane transport//tissue regeneration GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.54743 BF_2 146.45 1.12 5748 642913543 XP_971895.2 1130 3.5e-120 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 A9CPT4 170 3.0e-10 Tudor domain-containing protein 1 OS=Oryzias latipes GN=tdrd1 PE=2 SV=1 PF00097//PF06506//PF14634//PF00643//PF12678//PF01155//PF06003//PF01363//PF02736//PF16685//PF13639 Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator//zinc-RING finger domain//B-box zinc finger//RING-H2 zinc finger//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Survival motor neuron protein (SMN)//FYVE zinc finger//Myosin N-terminal SH3-like domain//zinc RING finger of MSL2//Ring finger domain GO:0006397//GO:0000160//GO:0006464 mRNA processing//phosphorelay signal transduction system//cellular protein modification process GO:0003774//GO:0046872//GO:0003677//GO:0003723//GO:0005515//GO:0061630//GO:0016151//GO:0000156//GO:0008270//GO:0005524 motor activity//metal ion binding//DNA binding//RNA binding//protein binding//ubiquitin protein ligase activity//nickel cation binding//phosphorelay response regulator activity//zinc ion binding//ATP binding GO:0005634//GO:0005622//GO:0005737//GO:0016459 nucleus//intracellular//cytoplasm//myosin complex -- -- Cluster-8309.54744 BF_2 327.44 2.88 5050 642913543 XP_971895.2 1210 1.6e-129 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 7.6e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF06003//PF00643//PF14634//PF02736//PF00097//PF06506 Survival motor neuron protein (SMN)//B-box zinc finger//zinc-RING finger domain//Myosin N-terminal SH3-like domain//Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator GO:0006397//GO:0000160 mRNA processing//phosphorelay signal transduction system GO:0005524//GO:0003723//GO:0003677//GO:0005515//GO:0008270//GO:0000156//GO:0003774//GO:0046872 ATP binding//RNA binding//DNA binding//protein binding//zinc ion binding//phosphorelay response regulator activity//motor activity//metal ion binding GO:0005634//GO:0016459//GO:0005622//GO:0005737 nucleus//myosin complex//intracellular//cytoplasm -- -- Cluster-8309.54747 BF_2 58.88 0.48 5440 642913543 XP_971895.2 672 4.2e-67 PREDICTED: RING finger protein 17 [Tribolium castaneum] -- -- -- -- -- K18405 TDRD1_4_6_7 tudor domain-containing protein 1/4/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K18405 Q9BXT4 166 8.2e-10 Tudor domain-containing protein 1 OS=Homo sapiens GN=TDRD1 PE=1 SV=2 PF06003//PF00643//PF14634//PF02736//PF00097//PF06506 Survival motor neuron protein (SMN)//B-box zinc finger//zinc-RING finger domain//Myosin N-terminal SH3-like domain//Zinc finger, C3HC4 type (RING finger)//Propionate catabolism activator GO:0000160//GO:0006397 phosphorelay signal transduction system//mRNA processing GO:0005515//GO:0003723//GO:0005524//GO:0003677//GO:0046872//GO:0008270//GO:0000156//GO:0003774 protein binding//RNA binding//ATP binding//DNA binding//metal ion binding//zinc ion binding//phosphorelay response regulator activity//motor activity GO:0005634//GO:0016459//GO:0005737//GO:0005622 nucleus//myosin complex//cytoplasm//intracellular -- -- Cluster-8309.54748 BF_2 5.23 0.31 989 642931088 XP_008196205.1 156 5.2e-08 PREDICTED: partner of Y14 and mago [Tribolium castaneum]>gi|270011886|gb|EFA08334.1| hypothetical protein TcasGA2_TC005977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07966//PF09268//PF09317 A1 Propeptide//Clathrin, heavy-chain linker//Domain of unknown function (DUF1974) GO:0006886//GO:0016192//GO:0055114//GO:0033539//GO:0006118//GO:0006508 intracellular protein transport//vesicle-mediated transport//oxidation-reduction process//fatty acid beta-oxidation using acyl-CoA dehydrogenase//obsolete electron transport//proteolysis GO:0005198//GO:0003995//GO:0004190 structural molecule activity//acyl-CoA dehydrogenase activity//aspartic-type endopeptidase activity GO:0030132//GO:0030130 clathrin coat of coated pit//clathrin coat of trans-Golgi network vesicle -- -- Cluster-8309.54749 BF_2 4.00 0.92 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54752 BF_2 1081.00 36.56 1524 646711129 KDR16428.1 913 1.3e-95 Lipase 3 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O46107 792 5.9e-83 Lipase 1 OS=Drosophila melanogaster GN=Lip1 PE=2 SV=2 PF01083//PF04083 Cutinase//Partial alpha/beta-hydrolase lipase region GO:0008152//GO:0006629 metabolic process//lipid metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.54753 BF_2 96.09 0.52 8022 91088309 XP_969421.1 1779 2.7e-195 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 808 4.4e-84 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF02254//PF05199//PF07992//PF07307//PF05834//PF00732//PF01266 TrkA-N domain//GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0055114//GO:0016117//GO:0009234//GO:0006813 oxidation-reduction process//carotenoid biosynthetic process//menaquinone biosynthetic process//potassium ion transport GO:0050660//GO:0016491//GO:0016614//GO:0016705 flavin adenine dinucleotide binding//oxidoreductase activity//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.54757 BF_2 44.49 4.68 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54763 BF_2 47.36 0.50 4280 642926786 XP_008195015.1 804 1.6e-82 PREDICTED: basic-leucine zipper transcription factor A-like [Tribolium castaneum]>gi|270009167|gb|EFA05615.1| hypothetical protein TcasGA2_TC015821 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZM4 177 3.4e-11 Glioma tumor suppressor candidate region gene 1 protein OS=Homo sapiens GN=GLTSCR1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54764 BF_2 96.56 1.25 3509 478254043 ENN74335.1 2208 2.1e-245 hypothetical protein YQE_09305, partial [Dendroctonus ponderosae] 462310547 APGK01047286.1 86 2.48109e-34 Dendroctonus ponderosae Seq01047296, whole genome shotgun sequence K10393 KIF2_24, MCAK kinesin family member 2/24 http://www.genome.jp/dbget-bin/www_bget?ko:K10393 Q5ZKV8 1495 4.1e-164 Kinesin-like protein KIF2A OS=Gallus gallus GN=KIF2A PE=2 SV=2 PF04889//PF00225 Cwf15/Cwc15 cell cycle control protein//Kinesin motor domain GO:0000398//GO:0007017//GO:0007018 mRNA splicing, via spliceosome//microtubule-based process//microtubule-based movement GO:0008017//GO:0003777//GO:0005524 microtubule binding//microtubule motor activity//ATP binding GO:0005681//GO:0005874//GO:0045298 spliceosomal complex//microtubule//tubulin complex KOG0246 Kinesin-like protein Cluster-8309.54766 BF_2 97.10 0.58 7341 189234456 XP_968035.2 3830 0.0e+00 PREDICTED: phosphatidylinositol 3-kinase catalytic subunit type 3 [Tribolium castaneum]>gi|270001744|gb|EEZ98191.1| hypothetical protein TcasGA2_TC000620 [Tribolium castaneum] 831497549 XM_012853965.1 227 2.16718e-112 PREDICTED: Fundulus heteroclitus phosphatidylinositol 3-kinase, catalytic subunit type 3 (pik3c3), mRNA K00914 PIK3C3, VPS34 phosphatidylinositol 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00914 Q6PF93 2695 6.2e-303 Phosphatidylinositol 3-kinase catalytic subunit type 3 OS=Mus musculus GN=Pik3c3 PE=1 SV=1 PF00454 Phosphatidylinositol 3- and 4-kinase GO:0036092//GO:0048015//GO:0046854 phosphatidylinositol-3-phosphate biosynthetic process//phosphatidylinositol-mediated signaling//phosphatidylinositol phosphorylation GO:0016303//GO:0016773//GO:0005524 1-phosphatidylinositol-3-kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding -- -- KOG0906 Phosphatidylinositol 3-kinase VPS34, involved in signal transduction Cluster-8309.54767 BF_2 117.72 4.39 1408 642935018 XP_968403.2 1217 7.0e-131 PREDICTED: WD repeat-containing protein 91 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZLL7 576 6.1e-58 WD repeat-containing protein 91 OS=Gallus gallus GN=WDR91 PE=2 SV=1 PF06815 Reverse transcriptase connection domain GO:0006278 RNA-dependent DNA replication GO:0003964 RNA-directed DNA polymerase activity -- -- KOG1333 Uncharacterized conserved protein Cluster-8309.5477 BF_2 1.00 0.44 380 -- -- -- -- -- 462317830 APGK01044596.1 44 5.5252e-12 Dendroctonus ponderosae Seq01044606, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54776 BF_2 101.56 0.54 8145 270015299 EFA11747.1 1766 8.8e-194 hypothetical protein TcasGA2_TC004237 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2VWP9 492 1.9e-47 Protogenin OS=Rattus norvegicus GN=Prtg PE=2 SV=1 PF16656//PF00041//PF13895 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain//Immunoglobulin domain GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0046872//GO:0005515//GO:0003993 metal ion binding//protein binding//acid phosphatase activity -- -- -- -- Cluster-8309.54780 BF_2 4.00 0.32 817 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54781 BF_2 66.87 0.85 3590 642929233 XP_008195746.1 1038 1.0e-109 PREDICTED: claspin homolog [Tribolium castaneum]>gi|270009673|gb|EFA06121.1| hypothetical protein TcasGA2_TC008964 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IRB5 380 8.3e-35 Claspin homolog OS=Drosophila melanogaster GN=CG32251 PE=1 SV=1 PF07827 KNTase C-terminal domain GO:0046677 response to antibiotic GO:0016779 nucleotidyltransferase activity -- -- KOG4156 Claspin, protein mediating phosphorylation and activation of Chk1 protein kinase in the DNA replication checkpoint response Cluster-8309.54782 BF_2 20.15 0.52 1903 741829513 AJA91072.1 1314 5.3e-142 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27594 886 9.3e-94 Cytochrome P450 6a9 OS=Drosophila melanogaster GN=Cyp6a9 PE=2 SV=3 PF00067//PF15681 Cytochrome P450//Lymphocyte activation family X GO:0006955//GO:0051249//GO:0055114 immune response//regulation of lymphocyte activation//oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.54794 BF_2 24.10 0.72 1692 546673463 ERL85061.1 595 1.1e-58 hypothetical protein D910_02484, partial [Dendroctonus ponderosae] 157136696 XM_001656830.1 41 1.22676e-09 Aedes aegypti AAEL013617-RA partial mRNA -- -- -- -- P15882 368 9.6e-34 N-chimaerin OS=Homo sapiens GN=CHN1 PE=1 SV=3 PF00620//PF04434 RhoGAP domain//SWIM zinc finger GO:0007165 signal transduction GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.54795 BF_2 52.71 0.73 3323 642935223 XP_008199698.1 2123 1.4e-235 PREDICTED: uncharacterized protein LOC103314735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58CV6 236 3.8e-18 Kelch domain-containing protein 3 OS=Bos taurus GN=KLHDC3 PE=2 SV=2 PF07646//PF01239//PF01344 Kelch motif//Protein prenyltransferase alpha subunit repeat//Kelch motif GO:0018342 protein prenylation GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity -- -- -- -- Cluster-8309.54798 BF_2 269.75 10.07 1408 642935798 XP_008198179.1 407 5.8e-37 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KHY8 171 5.6e-11 Leukocyte antigen CD37 OS=Bos taurus GN=CD37 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.548 BF_2 2.00 2.53 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54804 BF_2 311.02 3.21 4336 270012867 EFA09315.1 1048 8.5e-111 hypothetical protein TcasGA2_TC030748 [Tribolium castaneum] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 532 2.4e-52 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 PF04420 CHD5-like protein GO:0071816 tail-anchored membrane protein insertion into ER membrane -- -- -- -- KOG2687 Spindle pole body protein, contains UNC-84 domain Cluster-8309.54814 BF_2 32.06 0.97 1665 332375126 AEE62704.1 758 1.4e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q63528 327 5.4e-29 Replication protein A 32 kDa subunit OS=Rattus norvegicus GN=Rpa2 PE=2 SV=2 PF01336 OB-fold nucleic acid binding domain -- -- GO:0003676 nucleic acid binding -- -- KOG3108 Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit Cluster-8309.54816 BF_2 44.38 0.59 3435 546674875 ERL86161.1 2709 1.7e-303 hypothetical protein D910_03574 [Dendroctonus ponderosae] -- -- -- -- -- K12796 ERBB2IP, ERBIN erbb2-interacting protein http://www.genome.jp/dbget-bin/www_bget?ko:K12796 Q9V780 825 2.0e-86 Protein lap1 OS=Drosophila melanogaster GN=Lap1 PE=2 SV=1 PF00560//PF00595//PF13180//PF13855 Leucine Rich Repeat//PDZ domain (Also known as DHR or GLGF)//PDZ domain//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.54823 BF_2 199.00 2.64 3441 189236229 XP_001812942.1 1795 1.6e-197 PREDICTED: uncharacterized protein LOC100141771 [Tribolium castaneum] 642919319 XM_001812890.2 119 1.10016e-52 PREDICTED: Tribolium castaneum uncharacterized LOC100141771 (LOC100141771), mRNA -- -- -- -- Q9GNL3 175 4.7e-11 Transmembrane protein fend OS=Drosophila melanogaster GN=fend PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54825 BF_2 30.83 0.41 3450 189235122 XP_001811652.1 2006 5.5e-222 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 422 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1600 2.7e-176 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF15048//PF01496//PF00856 Organic solute transporter subunit beta protein//V-type ATPase 116kDa subunit family//SET domain GO:0006810//GO:0015721//GO:0015991//GO:0015992 transport//bile acid and bile salt transport//ATP hydrolysis coupled proton transport//proton transport GO:0046982//GO:0005515//GO:0005215//GO:0003682//GO:0015078 protein heterodimerization activity//protein binding//transporter activity//chromatin binding//hydrogen ion transmembrane transporter activity GO:0005886//GO:0000785//GO:0033179 plasma membrane//chromatin//proton-transporting V-type ATPase, V0 domain KOG1079 Transcriptional repressor EZH1 Cluster-8309.54827 BF_2 33.22 3.06 741 642019431 CDQ95405.1 351 9.6e-31 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- Q04202 161 4.2e-10 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 PF12844//PF01498//PF01047//PF08281//PF00292//PF00196//PF01325//PF13463//PF02796//PF04545//PF06056 Helix-turn-helix domain//Transposase//MarR family//Sigma-70, region 4//'Paired box' domain//Bacterial regulatory proteins, luxR family//Iron dependent repressor, N-terminal DNA binding domain//Winged helix DNA-binding domain//Helix-turn-helix domain of resolvase//Sigma-70, region 4//Putative ATPase subunit of terminase (gpP-like) GO:0019069//GO:0006352//GO:0015074//GO:0006355//GO:0006310//GO:0006313 viral capsid assembly//DNA-templated transcription, initiation//DNA integration//regulation of transcription, DNA-templated//DNA recombination//transposition, DNA-mediated GO:0003700//GO:0043565//GO:0016987//GO:0000150//GO:0005524//GO:0003677 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//sigma factor activity//recombinase activity//ATP binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.54828 BF_2 42.37 1.74 1305 270016600 EFA13046.1 231 1.4e-16 hypothetical protein TcasGA2_TC010748 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01283 Ribosomal protein S26e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.54829 BF_2 10.78 1.03 725 642019431 CDQ95405.1 363 3.8e-32 unnamed protein product [Oncorhynchus mykiss] -- -- -- -- -- -- -- -- -- Q04202 162 3.2e-10 Transposable element Tcb2 transposase OS=Caenorhabditis briggsae PE=3 SV=1 PF12844//PF01047//PF01498//PF08281//PF00196//PF01325//PF00292//PF06056//PF02796//PF04545 Helix-turn-helix domain//MarR family//Transposase//Sigma-70, region 4//Bacterial regulatory proteins, luxR family//Iron dependent repressor, N-terminal DNA binding domain//'Paired box' domain//Putative ATPase subunit of terminase (gpP-like)//Helix-turn-helix domain of resolvase//Sigma-70, region 4 GO:0006355//GO:0006310//GO:0015074//GO:0019069//GO:0006352//GO:0006313 regulation of transcription, DNA-templated//DNA recombination//DNA integration//viral capsid assembly//DNA-templated transcription, initiation//transposition, DNA-mediated GO:0016987//GO:0043565//GO:0003700//GO:0003677//GO:0005524//GO:0000150 sigma factor activity//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//DNA binding//ATP binding//recombinase activity GO:0005667 transcription factor complex -- -- Cluster-8309.54831 BF_2 457.78 9.38 2328 546680809 ERL91015.1 1217 1.2e-130 hypothetical protein D910_08357 [Dendroctonus ponderosae] -- -- -- -- -- K00731 C1GALT1 glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00731 Q7K237 1134 2.0e-122 Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 OS=Drosophila melanogaster GN=C1GalTA PE=2 SV=1 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane KOG2246 Galactosyltransferases Cluster-8309.54843 BF_2 89.62 0.42 9232 270014787 EFA11235.1 3899 0.0e+00 hypothetical protein TcasGA2_TC010767 [Tribolium castaneum] 642911510 XM_008201231.1 250 4.46947e-125 PREDICTED: Tribolium castaneum protein unc-79 homolog (LOC662785), mRNA -- -- -- -- Q9P2D8 1364 1.7e-148 Protein unc-79 homolog OS=Homo sapiens GN=UNC79 PE=2 SV=4 PF02020//PF08689 eIF4-gamma/eIF5/eIF2-epsilon//Mediator complex subunit Med5 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0005515//GO:0001104 protein binding//RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4820 Involved in anesthetic response in C.elegans Cluster-8309.54844 BF_2 22.00 1.26 1017 546683605 ERL93393.1 367 1.8e-32 hypothetical protein D910_10685 [Dendroctonus ponderosae] 347967642 XM_312638.5 77 7.0768e-30 Anopheles gambiae str. PEST AGAP002331-PA (AgaP_AGAP002331) mRNA, complete cds K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54845 BF_2 17.92 0.47 1882 642933408 XP_008197404.1 1792 2.0e-197 PREDICTED: sodium-independent sulfate anion transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 907 3.4e-96 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.54846 BF_2 51.70 1.35 1890 642933408 XP_008197404.1 1798 4.0e-198 PREDICTED: sodium-independent sulfate anion transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 903 9.9e-96 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.54847 BF_2 25.37 0.66 1894 642933408 XP_008197404.1 1793 1.5e-197 PREDICTED: sodium-independent sulfate anion transporter isoform X1 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 907 3.4e-96 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.54849 BF_2 387.00 16.24 1284 91079316 XP_967727.1 1251 7.2e-135 PREDICTED: 28S ribosomal protein S35, mitochondrial [Tribolium castaneum]>gi|270004335|gb|EFA00783.1| hypothetical protein TcasGA2_TC003669 [Tribolium castaneum] 195377909 XM_002047694.1 38 4.30219e-08 Drosophila virilis GJ13595 (Dvir\GJ13595), mRNA K17413 MRPS35 small subunit ribosomal protein S35 http://www.genome.jp/dbget-bin/www_bget?ko:K17413 Q2YDF6 779 1.6e-81 28S ribosomal protein S35, mitochondrial OS=Bos taurus GN=MRPS35 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3933 Mitochondrial ribosomal protein S28 Cluster-8309.54851 BF_2 37.46 1.59 1272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54856 BF_2 232.00 3.97 2730 91090155 XP_972292.1 566 4.1e-55 PREDICTED: uncharacterized protein LOC661009 [Tribolium castaneum]>gi|270013490|gb|EFA09938.1| hypothetical protein TcasGA2_TC012091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284//PF05823 Membrane-associating domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1) -- -- GO:0008289 lipid binding GO:0016020 membrane -- -- Cluster-8309.5486 BF_2 4.00 0.38 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54864 BF_2 1.00 0.31 421 676496824 XP_009067341.1 148 1.9e-07 hypothetical protein LOTGIDRAFT_176987, partial [Lottia gigantea]>gi|556093318|gb|ESO81971.1| hypothetical protein LOTGIDRAFT_176987, partial [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01381//PF05225 Helix-turn-helix//helix-turn-helix, Psq domain -- -- GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.54865 BF_2 41.16 0.34 5319 642919785 XP_008192065.1 3568 0.0e+00 PREDICTED: kinesin-like protein CG14535 isoform X2 [Tribolium castaneum] 759038090 XM_011353258.1 51 1.07947e-14 PREDICTED: Cerapachys biroi kinesin-like protein CG14535 (LOC105287618), mRNA K10404 KIF26 kinesin family member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10404 Q7TNC6 924 1.0e-97 Kinesin-like protein KIF26B OS=Mus musculus GN=Kif26b PE=1 SV=3 PF00225 Kinesin motor domain GO:0007017//GO:0007018 microtubule-based process//microtubule-based movement GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.54866 BF_2 265.00 8.06 1662 91087667 XP_973701.1 687 2.3e-69 PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase [Tribolium castaneum]>gi|270009414|gb|EFA05862.1| hypothetical protein TcasGA2_TC008662 [Tribolium castaneum] -- -- -- -- -- K01520 dut, DUT dUTP pyrophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01520 P33316 503 2.1e-49 Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial OS=Homo sapiens GN=DUT PE=1 SV=4 PF00692 dUTPase GO:0006206//GO:0046080 pyrimidine nucleobase metabolic process//dUTP metabolic process GO:0016787//GO:0004170 hydrolase activity//dUTP diphosphatase activity -- -- KOG3370 dUTPase Cluster-8309.54867 BF_2 17.81 0.32 2626 91095155 XP_967790.1 655 1.9e-65 PREDICTED: rRNA-processing protein UTP23 homolog [Tribolium castaneum]>gi|270015781|gb|EFA12229.1| hypothetical protein TcasGA2_TC004104 [Tribolium castaneum] -- -- -- -- -- K14773 UTP23 U3 small nucleolar RNA-associated protein 23 http://www.genome.jp/dbget-bin/www_bget?ko:K14773 Q9CX11 360 1.3e-32 rRNA-processing protein UTP23 homolog OS=Mus musculus GN=Utp23 PE=2 SV=1 PF04900 Fcf1 -- -- -- -- GO:0032040 small-subunit processome KOG3164 Uncharacterized proteins of PilT N-term./Vapc superfamily Cluster-8309.54871 BF_2 1.00 0.42 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54873 BF_2 9.00 2.55 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54874 BF_2 154.83 3.69 2042 642932314 XP_008197061.1 1608 4.6e-176 PREDICTED: ankyrin repeat and SAM domain-containing protein 4B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80T11 515 1.0e-50 Usher syndrome type-1G protein homolog OS=Mus musculus GN=Ush1g PE=1 SV=1 PF13606//PF01920//PF00536//PF10186//PF09128//PF07647//PF00023//PF14721 Ankyrin repeat//Prefoldin subunit//SAM domain (Sterile alpha motif)//Vacuolar sorting 38 and autophagy-related subunit 14//Regulator of G protein signalling-like domain//SAM domain (Sterile alpha motif)//Ankyrin repeat//Apoptosis-inducing factor, mitochondrion-associated, C-term GO:0006457//GO:0043087//GO:0010508 protein folding//regulation of GTPase activity//positive regulation of autophagy GO:0046983//GO:0005515//GO:0051082//GO:0005089 protein dimerization activity//protein binding//unfolded protein binding//Rho guanyl-nucleotide exchange factor activity GO:0016272//GO:0005737 prefoldin complex//cytoplasm -- -- Cluster-8309.54875 BF_2 35.24 1.33 1393 728416984 AIY68330.1 1146 1.2e-122 putative integument esterase [Leptinotarsa decemlineata] -- -- -- -- -- K01049 ACHE acetylcholinesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01049 P35502 533 5.8e-53 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06638//PF07859//PF00326 Strabismus protein//alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0007275//GO:0006508 metabolic process//multicellular organismal development//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity GO:0016021 integral component of membrane -- -- Cluster-8309.54879 BF_2 11.00 1.23 662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54881 BF_2 327.62 3.06 4769 642923667 XP_008193834.1 4031 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O15439 2431 1.6e-272 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF03193//PF00005//PF13304//PF01926//PF05972//PF00664//PF00437 Protein of unknown function, DUF258//ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//APC 15 residue motif//ABC transporter transmembrane region//Type II/IV secretion system protein GO:0006810//GO:0055085//GO:0016055 transport//transmembrane transport//Wnt signaling pathway GO:0042626//GO:0005525//GO:0008013//GO:0016887//GO:0003924//GO:0005524 ATPase activity, coupled to transmembrane movement of substances//GTP binding//beta-catenin binding//ATPase activity//GTPase activity//ATP binding GO:0016342//GO:0016021 catenin complex//integral component of membrane KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.54883 BF_2 27.00 56.89 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54884 BF_2 97.85 2.54 1899 642922360 XP_008193124.1 2313 7.6e-258 PREDICTED: sodium-coupled monocarboxylate transporter 1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q3ZMH1 1054 3.1e-113 Sodium-coupled monocarboxylate transporter 1 OS=Danio rerio GN=slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.54885 BF_2 88.00 2.53 1744 270016741 EFA13187.1 182 8.9e-11 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54887 BF_2 386.46 6.16 2911 642927093 XP_008195135.1 2894 0.0e+00 PREDICTED: rhophilin-2 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TNR1 1245 3.4e-135 Rhophilin-2 OS=Danio rerio GN=rhpn2 PE=2 SV=1 PF02185//PF00595//PF13180 Hr1 repeat//PDZ domain (Also known as DHR or GLGF)//PDZ domain GO:0007165 signal transduction GO:0005515 protein binding -- -- KOG2220 Predicted signal transduction protein Cluster-8309.54888 BF_2 89.05 2.67 1684 642929512 XP_975068.2 1084 2.2e-115 PREDICTED: 3'(2'),5'-bisphosphate nucleotidase 1 isoform X1 [Tribolium castaneum] 727003473 XM_010393578.1 39 1.57925e-08 PREDICTED: Corvus cornix cornix 3'(2'), 5'-bisphosphate nucleotidase 1 (BPNT1), mRNA K01082 cysQ, MET22, BPNT1 3'(2'), 5'-bisphosphate nucleotidase http://www.genome.jp/dbget-bin/www_bget?ko:K01082 O95861 750 4.8e-78 3'(2'),5'-bisphosphate nucleotidase 1 OS=Homo sapiens GN=BPNT1 PE=1 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.54890 BF_2 417.83 8.94 2243 642924819 XP_008194054.1 939 1.9e-98 PREDICTED: pre-mRNA 3'-end-processing factor FIP1 isoform X1 [Tribolium castaneum] 755881436 XM_005185743.2 56 7.49862e-18 PREDICTED: Musca domestica pre-mRNA 3'-end-processing factor FIP1 (LOC101888314), mRNA K14405 FIP1L1, FIP1 pre-mRNA 3'-end-processing factor FIP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14405 Q9D824 301 7.5e-26 Pre-mRNA 3'-end-processing factor FIP1 OS=Mus musculus GN=Fip1l1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1049 Polyadenylation factor I complex, subunit FIP1 Cluster-8309.54894 BF_2 61.14 0.64 4263 478249815 ENN70322.1 632 1.4e-62 hypothetical protein YQE_12833, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6PR54 154 1.6e-08 Telomere-associated protein RIF1 OS=Mus musculus GN=Rif1 PE=1 SV=2 PF02252//PF03118 Proteasome activator pa28 beta subunit//Bacterial RNA polymerase, alpha chain C terminal domain GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0008537//GO:0005730 proteasome activator complex//nucleolus -- -- Cluster-8309.54900 BF_2 27.79 0.88 1608 642917916 XP_008191381.1 387 1.4e-34 PREDICTED: methyltransferase-like protein 17, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3U2U7 193 1.8e-13 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.54901 BF_2 42.57 11.05 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5491 BF_2 13.00 0.39 1698 91091008 XP_975006.1 1136 2.1e-121 PREDICTED: homeobox protein BarH-like 1 [Tribolium castaneum]>gi|270013179|gb|EFA09627.1| hypothetical protein TcasGA2_TC011748 [Tribolium castaneum] 642936140 XM_969913.2 242 2.26488e-121 PREDICTED: Tribolium castaneum homeobox protein BarH-like 1 (LOC663883), mRNA K09353 LBX homeobox protein LBX http://www.genome.jp/dbget-bin/www_bget?ko:K09353 Q0P4H6 401 1.4e-37 Transcription factor LBX1 OS=Xenopus tropicalis GN=lbx1 PE=2 SV=1 PF01186//PF00046//PF05920 Lysyl oxidase//Homeobox domain//Homeobox KN domain GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0016641//GO:0003677//GO:0005507//GO:0043565 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor//DNA binding//copper ion binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.54912 BF_2 22.00 1.28 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.54913 BF_2 20.00 1.36 902 723587484 AIX97362.1 1380 5.6e-150 heat shock protein 70 [Charybdis japonica] 418206096 JX913781.1 896 0 Scylla paramamosain isolate S5 heat shock protein 70 (hsp70) gene, complete cds K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P08108 1272 7.7e-139 Heat shock cognate 70 kDa protein OS=Oncorhynchus mykiss GN=hsc71 PE=2 SV=2 PF07748//PF02854//PF01968//PF06723//PF02782 Glycosyl hydrolases family 38 C-terminal domain//MIF4G domain//Hydantoinase/oxoprolinase//MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0000902//GO:0005975//GO:0006013 cell morphogenesis//carbohydrate metabolic process//mannose metabolic process GO:0016787//GO:0003723//GO:0015923//GO:0005515//GO:0016773 hydrolase activity//RNA binding//mannosidase activity//protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.54915 BF_2 5.00 0.54 673 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09907 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.54921 BF_2 45.28 0.70 3006 -- -- -- -- -- 642924274 XM_008196005.1 39 2.84348e-08 PREDICTED: Tribolium castaneum uncharacterized LOC103313241 (LOC103313241), transcript variant X2, mRNA -- -- -- -- -- -- -- -- PF00008//PF07645//PF13895 EGF-like domain//Calcium-binding EGF domain//Immunoglobulin domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.54935 BF_2 145.70 2.95 2352 91085197 XP_971808.1 1006 3.4e-106 PREDICTED: serine/threonine-protein phosphatase Pgam5, mitochondrial isoform X1 [Tribolium castaneum]>gi|270008461|gb|EFA04909.1| hypothetical protein TcasGA2_TC014973 [Tribolium castaneum] -- -- -- -- -- K15637 PGAM5 serine/threonine-protein phosphatase PGAM5 http://www.genome.jp/dbget-bin/www_bget?ko:K15637 B3MR30 705 1.1e-72 Serine/threonine-protein phosphatase Pgam5, mitochondrial OS=Drosophila ananassae GN=Pgam5 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4609 Predicted phosphoglycerate mutase Cluster-8309.54938 BF_2 54.21 1.76 1572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54940 BF_2 80.59 1.64 2340 478255274 ENN75503.1 1441 1.2e-156 hypothetical protein YQE_08052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00884//PF01663 Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0008152 metabolic process GO:0003824//GO:0008484 catalytic activity//sulfuric ester hydrolase activity -- -- -- -- Cluster-8309.54941 BF_2 29.39 0.54 2555 642938493 XP_008198006.1 875 5.7e-91 PREDICTED: nose resistant to fluoxetine protein 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 255 1.8e-20 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF07694//PF01757 5TMR of 5TMR-LYT//Acyltransferase family GO:0071555//GO:0016310//GO:0000160 cell wall organization//phosphorylation//phosphorelay signal transduction system GO:0016747//GO:0004673//GO:0000155 transferase activity, transferring acyl groups other than amino-acyl groups//protein histidine kinase activity//phosphorelay sensor kinase activity GO:0009365//GO:0016021 protein histidine kinase complex//integral component of membrane -- -- Cluster-8309.54943 BF_2 310.56 7.21 2088 189233695 XP_001812208.1 757 2.3e-77 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 611 7.9e-62 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.54948 BF_2 208.96 9.50 1207 91083701 XP_969551.1 798 2.3e-82 PREDICTED: PITH domain-containing protein CG6153 [Tribolium castaneum]>gi|270006812|gb|EFA03260.1| hypothetical protein TcasGA2_TC013194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29L80 614 2.0e-62 PITH domain-containing protein GA19395 OS=Drosophila pseudoobscura pseudoobscura GN=GA19395 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1730 Thioredoxin-like protein Cluster-8309.54951 BF_2 77.00 2.35 1655 641667737 XP_008184195.1 486 4.7e-46 PREDICTED: zinc finger protein 227-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q03938 436 1.2e-41 Zinc finger protein 90 OS=Homo sapiens GN=ZNF90 PE=2 SV=3 PF13465//PF00096//PF06467//PF16622//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//zinc-finger C2H2-type//C2H2-type zinc finger -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- -- -- Cluster-8309.54952 BF_2 47.40 2.79 997 557025110 XP_006012719.1 402 1.6e-36 PREDICTED: zinc finger protein 850-like [Latimeria chalumnae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P16374 406 2.2e-38 Zinc finger protein 60 OS=Mus musculus GN=Zfp60 PE=2 SV=2 PF13465//PF00096//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.54953 BF_2 6.60 0.35 1075 612027816 XP_007492787.1 371 6.7e-33 PREDICTED: zinc finger protein 420-like isoform X1 [Monodelphis domestica]>gi|612027818|ref|XP_007492788.1| PREDICTED: zinc finger protein 420-like isoform X2 [Monodelphis domestica] -- -- -- -- -- -- -- -- -- P16374 370 3.6e-34 Zinc finger protein 60 OS=Mus musculus GN=Zfp60 PE=2 SV=2 PF02146//PF13465//PF01428//PF07648//PF16622//PF04810//PF13912//PF06397//PF01155//PF00130//PF00096//PF06467//PF02519 Sir2 family//Zinc-finger double domain//AN1-like Zinc finger//Kazal-type serine protease inhibitor domain//zinc-finger C2H2-type//Sec23/Sec24 zinc finger//C2H2-type zinc finger//Desulfoferrodoxin, N-terminal domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//MYM-type Zinc finger with FCS sequence motif//Auxin responsive protein GO:0006888//GO:0006886//GO:0006464//GO:0035556//GO:0009733 ER to Golgi vesicle-mediated transport//intracellular protein transport//cellular protein modification process//intracellular signal transduction//response to auxin GO:0005515//GO:0016151//GO:0070403//GO:0046872//GO:0005506//GO:0008270 protein binding//nickel cation binding//NAD+ binding//metal ion binding//iron ion binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.54954 BF_2 1.00 0.99 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54956 BF_2 239.26 4.02 2780 642917874 XP_969397.3 2186 6.0e-243 PREDICTED: ras-specific guanine nucleotide-releasing factor RalGPS1-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4R7W3 1050 1.3e-112 Ras-specific guanine nucleotide-releasing factor RalGPS2 OS=Macaca fascicularis GN=RALGPS2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.54959 BF_2 83.70 2.24 1853 478251538 ENN72000.1 1061 1.1e-112 hypothetical protein YQE_11291, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SWK7 184 2.3e-12 RING finger protein 145 OS=Mus musculus GN=Rnf145 PE=2 SV=1 PF00097//PF12861//PF14634//PF12678//PF17123//PF13639 Zinc finger, C3HC4 type (RING finger)//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain//RING-H2 zinc finger//RING-like zinc finger//Ring finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0046872//GO:0005515//GO:0004842 zinc ion binding//metal ion binding//protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG0802 E3 ubiquitin ligase Cluster-8309.54960 BF_2 309.08 11.04 1458 332376709 AEE63494.1 1834 2.0e-202 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NWM0 504 1.4e-49 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.54961 BF_2 24.12 0.77 1598 332376709 AEE63494.1 1235 6.5e-133 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00308 PAOX N1-acetylpolyamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00308 Q6QHF9 464 6.7e-45 Peroxisomal N(1)-acetyl-spermine/spermidine oxidase OS=Homo sapiens GN=PAOX PE=1 SV=3 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.54965 BF_2 1.29 0.51 392 91084281 XP_971525.1 218 1.3e-15 PREDICTED: fatty acid synthase [Tribolium castaneum]>gi|270008801|gb|EFA05249.1| hypothetical protein TcasGA2_TC015400 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.54967 BF_2 2.38 0.32 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54969 BF_2 3.62 0.94 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54971 BF_2 27.90 3.44 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54972 BF_2 51.97 0.74 3242 546683476 ERL93282.1 267 2.3e-20 hypothetical protein D910_10578 [Dendroctonus ponderosae] -- -- -- -- -- K11498 CENPE centromeric protein E http://www.genome.jp/dbget-bin/www_bget?ko:K11498 Q6RT24 209 5.0e-15 Centromere-associated protein E OS=Mus musculus GN=Cenpe PE=1 SV=1 PF08826//PF04675//PF09726//PF03938//PF00225//PF00170//PF00435//PF04111 DMPK coiled coil domain like//DNA ligase N terminus//Transmembrane protein//Outer membrane protein (OmpH-like)//Kinesin motor domain//bZIP transcription factor//Spectrin repeat//Autophagy protein Apg6 GO:0016310//GO:0006310//GO:0007018//GO:0006281//GO:0009069//GO:0006914//GO:0006468//GO:0006260//GO:0006355//GO:0007017 phosphorylation//DNA recombination//microtubule-based movement//DNA repair//serine family amino acid metabolic process//autophagy//protein phosphorylation//DNA replication//regulation of transcription, DNA-templated//microtubule-based process GO:0003677//GO:0005515//GO:0003777//GO:0008017//GO:0003910//GO:0005524//GO:0051082//GO:0043565//GO:0004674//GO:0003700 DNA binding//protein binding//microtubule motor activity//microtubule binding//DNA ligase (ATP) activity//ATP binding//unfolded protein binding//sequence-specific DNA binding//protein serine/threonine kinase activity//transcription factor activity, sequence-specific DNA binding GO:0005874//GO:0005667//GO:0016021//GO:0045298 microtubule//transcription factor complex//integral component of membrane//tubulin complex KOG0242 Kinesin-like protein Cluster-8309.54974 BF_2 9.11 0.54 989 -- -- -- -- -- 462310927 APGK01047154.1 60 1.93881e-20 Dendroctonus ponderosae Seq01047164, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54977 BF_2 4.00 3.53 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54978 BF_2 42.00 2.40 1020 321472662 EFX83631.1 442 3.7e-41 hypothetical protein DAPPUDRAFT_100237 [Daphnia pulex] -- -- -- -- -- K03135 TAF11 transcription initiation factor TFIID subunit 11 http://www.genome.jp/dbget-bin/www_bget?ko:K03135 Q99JX1 373 1.5e-34 Transcription initiation factor TFIID subunit 11 OS=Mus musculus GN=Taf11 PE=2 SV=1 PF17085//PF12289//PF04719 Unique cartilage matrix associated protein//Rotavirus VP1 C-terminal domain//hTAFII28-like protein conserved region GO:0045667//GO:0006144//GO:0006367 regulation of osteoblast differentiation//purine nucleobase metabolic process//transcription initiation from RNA polymerase II promoter GO:0003968 RNA-directed RNA polymerase activity GO:0005634//GO:0031379 nucleus//RNA-directed RNA polymerase complex -- -- Cluster-8309.54979 BF_2 1.00 6.98 243 307203486 EFN82537.1 145 2.4e-07 hypothetical protein EAI_16874, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54981 BF_2 9.38 1.58 536 270012085 EFA08533.1 386 6.0e-35 hypothetical protein TcasGA2_TC006187 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54982 BF_2 12.00 4.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.54985 BF_2 8.23 0.71 775 189239014 XP_974755.2 424 3.4e-39 PREDICTED: CCR4-NOT transcription complex subunit 11 [Tribolium castaneum]>gi|270009833|gb|EFA06281.1| hypothetical protein TcasGA2_TC009147 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UKZ1 176 8.1e-12 CCR4-NOT transcription complex subunit 11 OS=Homo sapiens GN=CNOT11 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.54987 BF_2 385.28 6.87 2634 642916487 XP_008191063.1 996 5.5e-105 PREDICTED: glutathione S-transferase-like [Tribolium castaneum]>gi|642916489|ref|XP_008191064.1| PREDICTED: glutathione S-transferase-like [Tribolium castaneum]>gi|270003617|gb|EFA00065.1| hypothetical protein TcasGA2_TC002878 [Tribolium castaneum] -- -- -- -- -- K01830 E5.3.99.2, PTGDS prostaglandin-H2 D-isomerase http://www.genome.jp/dbget-bin/www_bget?ko:K01830 O18598 466 6.5e-45 Glutathione S-transferase OS=Blattella germanica PE=1 SV=3 PF05529//PF13417//PF02798//PF13409 B-cell receptor-associated protein 31-like//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain GO:0006886 intracellular protein transport GO:0005515 protein binding GO:0005783//GO:0016021 endoplasmic reticulum//integral component of membrane KOG1695 Glutathione S-transferase Cluster-8309.54988 BF_2 207.35 7.43 1454 642925505 XP_008194578.1 806 3.3e-83 PREDICTED: very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase [Tribolium castaneum]>gi|270008695|gb|EFA05143.1| hypothetical protein TcasGA2_TC015260 [Tribolium castaneum] -- -- -- -- -- K10703 PHS1, PAS2 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K10703 Q7SY06 390 2.3e-36 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase OS=Danio rerio GN=hacd3 PE=2 SV=2 PF04999//PF06687 Cell division protein FtsL//SUR7/PalI family GO:0007049//GO:0051301 cell cycle//cell division -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane KOG3187 Protein tyrosine phosphatase-like protein PTPLA (contains Pro instead of catalytic Arg) Cluster-8309.5499 BF_2 15.00 0.38 1921 795340201 XP_011782384.1 2476 9.7e-277 PREDICTED: heat shock cognate 71 kDa protein isoform X2 [Colobus angolensis palliatus]>gi|649136092|gb|AIC59023.1| HSPA8, partial [synthetic construct] 767970090 XM_011542798.1 1840 0 PREDICTED: Homo sapiens heat shock 70kDa protein 8 (HSPA8), transcript variant X1, mRNA K03283 HSPA1_8 heat shock 70kDa protein 1/8 http://www.genome.jp/dbget-bin/www_bget?ko:K03283 P11142 2476 4.0e-278 Heat shock cognate 71 kDa protein OS=Homo sapiens GN=HSPA8 PE=1 SV=1 PF06723//PF02782 MreB/Mbl protein//FGGY family of carbohydrate kinases, C-terminal domain GO:0005975//GO:0000902 carbohydrate metabolic process//cell morphogenesis GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG0101 Molecular chaperones HSP70/HSC70, HSP70 superfamily Cluster-8309.54990 BF_2 232.40 2.18 4754 642925869 XP_008190626.1 2498 6.8e-279 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 9 isoform X2 [Tribolium castaneum] -- -- -- -- -- K08624 ADAMTS9 a disintegrin and metalloproteinase with thrombospondin motifs 9 http://www.genome.jp/dbget-bin/www_bget?ko:K08624 Q9P2N4 1274 2.4e-138 A disintegrin and metalloproteinase with thrombospondin motifs 9 OS=Homo sapiens GN=ADAMTS9 PE=1 SV=4 PF01562//PF05986//PF00413//PF01421 Reprolysin family propeptide//ADAM-TS Spacer 1//Matrixin//Reprolysin (M12B) family zinc metalloprotease GO:0006508 proteolysis GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding GO:0031012 extracellular matrix KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.54992 BF_2 106.67 7.29 899 91093645 XP_967622.1 952 2.4e-100 PREDICTED: translation initiation factor eIF-2B subunit beta [Tribolium castaneum]>gi|270015813|gb|EFA12261.1| hypothetical protein TcasGA2_TC016125 [Tribolium castaneum] -- -- -- -- -- K03754 EIF2B2 translation initiation factor eIF-2B subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K03754 Q90511 660 7.1e-68 Translation initiation factor eIF-2B subunit beta OS=Takifugu rubripes GN=eif2b2 PE=3 SV=1 PF01008 Initiation factor 2 subunit family GO:0044237 cellular metabolic process -- -- -- -- KOG1465 Translation initiation factor 2B, beta subunit (eIF-2Bbeta/GCD7) Cluster-8309.54993 BF_2 10.00 4.08 388 699648536 XP_009879813.1 232 3.2e-17 PREDICTED: fibroblast growth factor receptor 1-like [Charadrius vociferus] 188219627 NG_007729.1 388 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P11362 221 2.4e-17 Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55000 BF_2 56.00 2.73 1145 270007727 EFA04175.1 1105 5.5e-118 hypothetical protein TcasGA2_TC014424 [Tribolium castaneum] 462299229 APGK01051387.1 59 8.11226e-20 Dendroctonus ponderosae Seq01051397, whole genome shotgun sequence K15297 RIMS2, RIM2 regulating synaptic membrane exocytosis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15297 Q9JIS1 324 8.2e-29 Regulating synaptic membrane exocytosis protein 2 OS=Rattus norvegicus GN=Rims2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3799 Rab3 effector RIM1 and related proteins, contain Rab3a binding domain Cluster-8309.55003 BF_2 57.80 0.35 7232 546684778 ERL94373.1 2654 8.4e-297 hypothetical protein D910_11653 [Dendroctonus ponderosae] -- -- -- -- -- K19178 HELQ POLQ-like helicase http://www.genome.jp/dbget-bin/www_bget?ko:K19178 Q8TDG4 1450 1.4e-158 Helicase POLQ-like OS=Homo sapiens GN=HELQ PE=1 SV=2 PF05175//PF08241//PF05206//PF10391//PF05148//PF00270 Methyltransferase small domain//Methyltransferase domain//Methyltransferase TRM13//Fingers domain of DNA polymerase lambda//Hypothetical methyltransferase//DEAD/DEAH box helicase GO:0008152//GO:0008033 metabolic process//tRNA processing GO:0005524//GO:0003677//GO:0034061//GO:0008168//GO:0003676 ATP binding//DNA binding//DNA polymerase activity//methyltransferase activity//nucleic acid binding GO:0005634 nucleus KOG0950 DNA polymerase theta/eta, DEAD-box superfamily Cluster-8309.55004 BF_2 22.00 2.05 735 295982350 3KWQ 410 1.4e-37 Chain B, Structural Characterization Of H3k56q Nucleosomes And Nucleo Arrays>gi|295982354|pdb|3KWQ|F Chain F, Structural Characterization Of H3k56q Nucleosomes And Nucleo Arrays>gi|409107476|pdb|4H9S|C Chain C, Complex Structure 6 Of DaxxH3.3(SUB7)H4>gi|409107477|pdb|4H9S|D Chain D, Complex Structure 6 Of DaxxH3.3(SUB7)H4 512938600 XM_004933988.1 124 3.76569e-56 PREDICTED: Bombyx mori histone H4-like (LOC101736075), mRNA K11254 H4 histone H4 http://www.genome.jp/dbget-bin/www_bget?ko:K11254 P62790 361 2.7e-33 Histone H4 OS=Sterkiella nova PE=3 SV=2 PF02291//PF00125//PF02969 Transcription initiation factor IID, 31kD subunit//Core histone H2A/H2B/H3/H4//TATA box binding protein associated factor (TAF) GO:0006352//GO:0006334 DNA-templated transcription, initiation//nucleosome assembly GO:0046982//GO:0003677 protein heterodimerization activity//DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.55005 BF_2 16.00 2.72 533 620949140 XP_001513000.2 694 1.2e-70 PREDICTED: uncharacterized protein LOC100089390 [Ornithorhynchus anatinus] 27923434 AY125228.1 164 1.55722e-78 Ophiogomphus severus histone 3 gene, partial cds K11253 H3 histone H3 http://www.genome.jp/dbget-bin/www_bget?ko:K11253 P84234 675 7.6e-70 Histone H3.2 OS=Oncorhynchus mykiss PE=1 SV=2 PF15715//PF00125 PCNA-associated factor//Core histone H2A/H2B/H3/H4 GO:0051726//GO:0006974 regulation of cell cycle//cellular response to DNA damage stimulus GO:0003677 DNA binding -- -- -- -- Cluster-8309.55006 BF_2 15.35 0.60 1361 270009017 EFA05465.1 754 3.3e-77 hypothetical protein TcasGA2_TC015648 [Tribolium castaneum] 462343094 APGK01035499.1 48 1.26096e-13 Dendroctonus ponderosae Seq01035509, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02284 Cytochrome c oxidase subunit Va GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005743 respiratory chain complex IV//mitochondrial inner membrane -- -- Cluster-8309.55007 BF_2 43.00 0.64 3096 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55014 BF_2 2.00 0.53 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15339//PF00957 Acrosome formation-associated factor//Synaptobrevin GO:0060478//GO:0007342//GO:0006897//GO:0016192 acrosomal vesicle exocytosis//fusion of sperm to egg plasma membrane//endocytosis//vesicle-mediated transport -- -- GO:0005886//GO:0016021 plasma membrane//integral component of membrane -- -- Cluster-8309.55015 BF_2 6.00 0.82 595 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55016 BF_2 68.70 13.31 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55017 BF_2 51.00 1.44 1772 91094245 XP_968572.1 479 3.3e-45 PREDICTED: transcription factor 21 [Tribolium castaneum]>gi|270016269|gb|EFA12715.1| hypothetical protein TcasGA2_TC002349 [Tribolium castaneum] -- -- -- -- -- K09072 MSC musculin (activated B-cell factor-1) http://www.genome.jp/dbget-bin/www_bget?ko:K09072 O88940 240 7.0e-19 Musculin OS=Mus musculus GN=Msc PE=1 SV=1 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.55018 BF_2 66.87 8.66 610 91085409 XP_967434.1 224 4.2e-16 PREDICTED: prostatic acid phosphatase [Tribolium castaneum]>gi|270009157|gb|EFA05605.1| hypothetical protein TcasGA2_TC015811 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.5502 BF_2 16.00 0.49 1649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55025 BF_2 31.32 0.54 2735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55026 BF_2 10.00 0.38 1380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13994 PgaD-like protein GO:0042710 biofilm formation -- -- -- -- -- -- Cluster-8309.55029 BF_2 111.86 2.83 1939 642916248 XP_008190945.1 1988 3.8e-220 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642916250|ref|XP_008190946.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270003683|gb|EFA00131.1| hypothetical protein TcasGA2_TC002947 [Tribolium castaneum] -- -- -- -- -- K08202 SLC22A4_5, OCTN MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K08202 Q9VCA2 1558 1.1e-171 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.55031 BF_2 53.88 0.58 4195 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55032 BF_2 86.06 0.70 5463 642919497 XP_008191896.1 2940 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55034 BF_2 43.22 1.00 2103 189233639 XP_001813427.1 925 7.5e-97 PREDICTED: tight junction protein ZO-3 [Tribolium castaneum]>gi|642910523|ref|XP_008200248.1| PREDICTED: tight junction protein ZO-3 [Tribolium castaneum]>gi|270014407|gb|EFA10855.1| hypothetical protein TcasGA2_TC001632 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZR8 271 2.1e-22 PDZ domain-containing protein 2 OS=Rattus norvegicus GN=Pdzd2 PE=1 SV=1 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55037 BF_2 11.00 0.83 843 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55038 BF_2 5.00 0.32 950 91080851 XP_971681.1 202 2.3e-13 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005416|gb|EFA01864.1| hypothetical protein TcasGA2_TC007467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01061 ABC-2 type transporter GO:0006200 obsolete ATP catabolic process GO:0005524//GO:0016887 ATP binding//ATPase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.55043 BF_2 45.32 0.96 2265 91079796 XP_968202.1 2037 9.2e-226 PREDICTED: protein GPR107 [Tribolium castaneum]>gi|270003308|gb|EEZ99755.1| hypothetical protein TcasGA2_TC002527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BUV8 1081 2.7e-116 Protein GPR107 OS=Mus musculus GN=Gpr107 PE=2 SV=2 PF06814//PF10192//PF04420 Lung seven transmembrane receptor//Rhodopsin-like GPCR transmembrane domain//CHD5-like protein GO:0019236//GO:0071816//GO:0007186 response to pheromone//tail-anchored membrane protein insertion into ER membrane//G-protein coupled receptor signaling pathway -- -- GO:0016021 integral component of membrane KOG2569 G protein-coupled seven transmembrane receptor Cluster-8309.55045 BF_2 765.25 15.73 2322 91079796 XP_968202.1 2037 9.4e-226 PREDICTED: protein GPR107 [Tribolium castaneum]>gi|270003308|gb|EEZ99755.1| hypothetical protein TcasGA2_TC002527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BUV8 1081 2.8e-116 Protein GPR107 OS=Mus musculus GN=Gpr107 PE=2 SV=2 PF06814//PF10192//PF04420 Lung seven transmembrane receptor//Rhodopsin-like GPCR transmembrane domain//CHD5-like protein GO:0071816//GO:0007186//GO:0019236 tail-anchored membrane protein insertion into ER membrane//G-protein coupled receptor signaling pathway//response to pheromone -- -- GO:0016021 integral component of membrane KOG2569 G protein-coupled seven transmembrane receptor Cluster-8309.55047 BF_2 94.40 4.51 1162 642931053 XP_973827.2 1132 4.1e-121 PREDICTED: isoaspartyl peptidase/L-asparaginase [Tribolium castaneum] -- -- -- -- -- K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q29I93 723 4.5e-75 Probable isoaspartyl peptidase/L-asparaginase GA20639 OS=Drosophila pseudoobscura pseudoobscura GN=GA20639 PE=3 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1592 Asparaginase Cluster-8309.55050 BF_2 3.00 99.06 206 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00879 Defensin propeptide GO:0006952 defense response -- -- -- -- -- -- Cluster-8309.55052 BF_2 54.44 1.55 1753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55053 BF_2 1257.78 31.97 1933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041 Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55055 BF_2 11.36 0.53 1185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55056 BF_2 12.95 0.43 1539 642929034 XP_008195662.1 494 5.2e-47 PREDICTED: borealin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 1.1e-07 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55058 BF_2 237.21 5.07 2243 642914217 XP_008201594.1 1758 2.0e-193 PREDICTED: abl interactor 2-like [Tribolium castaneum]>gi|270001565|gb|EEZ98012.1| hypothetical protein TcasGA2_TC000412 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NYB9 522 1.8e-51 Abl interactor 2 OS=Homo sapiens GN=ABI2 PE=1 SV=1 PF07815//PF00031//PF00018//PF14604//PF01110 Abl-interactor HHR//Cystatin domain//SH3 domain//Variant SH3 domain//Ciliary neurotrophic factor GO:0040007 growth GO:0005515//GO:0004869 protein binding//cysteine-type endopeptidase inhibitor activity GO:0005737 cytoplasm KOG2546 Abl interactor ABI-1, contains SH3 domain Cluster-8309.55060 BF_2 43.86 1.12 1923 642921796 XP_008199323.1 458 9.7e-43 PREDICTED: transcription initiation factor IIB [Tribolium castaneum]>gi|270006604|gb|EFA03052.1| hypothetical protein TcasGA2_TC010900 [Tribolium castaneum] 564239149 XM_006276368.1 53 2.98315e-16 PREDICTED: Alligator mississippiensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 411 1.1e-38 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 -- -- GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0008270//GO:0017025 zinc ion binding//TBP-class protein binding -- -- KOG1597 Transcription initiation factor TFIIB Cluster-8309.55062 BF_2 65.52 0.75 3951 357622566 EHJ73993.1 2017 3.3e-223 fanconi anemia group J protein [Danaus plexippus] -- -- -- -- -- K11136 RTEL1 regulator of telomere elongation helicase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11136 B0W9F4 1803 9.0e-200 Regulator of telomere elongation helicase 1 homolog OS=Culex quinquefasciatus GN=CPIJ003765 PE=3 SV=1 PF13307//PF00270//PF04851//PF02562//PF00176//PF06733 Helicase C-terminal domain//DEAD/DEAH box helicase//Type III restriction enzyme, res subunit//PhoH-like protein//SNF2 family N-terminal domain//DEAD_2 GO:0006139 nucleobase-containing compound metabolic process GO:0008026//GO:0003677//GO:0016787//GO:0005524//GO:0016818//GO:0003676//GO:0004003 ATP-dependent helicase activity//DNA binding//hydrolase activity//ATP binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//nucleic acid binding//ATP-dependent DNA helicase activity GO:0005657 replication fork KOG1132 Helicase of the DEAD superfamily Cluster-8309.55063 BF_2 140.28 1.03 5995 546674397 ERL85784.1 3145 0.0e+00 hypothetical protein D910_03199 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55065 BF_2 14.00 1.38 712 283468932 CAP53905.1 240 6.8e-18 histone H1 orphon [Xenoturbella bocki] -- -- -- -- -- K11275 H1_5 histone H1/5 http://www.genome.jp/dbget-bin/www_bget?ko:K11275 P15870 207 1.9e-15 Histone H1-delta OS=Strongylocentrotus purpuratus PE=3 SV=1 PF00538//PF01402 linker histone H1 and H5 family//Ribbon-helix-helix protein, copG family GO:0006355//GO:0006334 regulation of transcription, DNA-templated//nucleosome assembly GO:0003677 DNA binding GO:0005634//GO:0000786 nucleus//nucleosome -- -- Cluster-8309.55066 BF_2 503.24 3.76 5888 642937896 XP_008200347.1 2573 1.7e-287 PREDICTED: protein vav isoform X1 [Tribolium castaneum] -- -- -- -- -- K05730 VAV guanine nucleotide exchange factor VAV http://www.genome.jp/dbget-bin/www_bget?ko:K05730 Q9NHV9 1473 2.5e-161 Protein vav OS=Drosophila melanogaster GN=Vav PE=1 SV=2 PF00130//PF00307//PF14604//PF00018//PF00621 Phorbol esters/diacylglycerol binding domain (C1 domain)//Calponin homology (CH) domain//Variant SH3 domain//SH3 domain//RhoGEF domain GO:0035023//GO:0043087//GO:0035556 regulation of Rho protein signal transduction//regulation of GTPase activity//intracellular signal transduction GO:0005089//GO:0005515 Rho guanyl-nucleotide exchange factor activity//protein binding -- -- KOG2996 Rho guanine nucleotide exchange factor VAV3 Cluster-8309.55078 BF_2 2.00 0.70 406 642939245 XP_008194776.1 275 3.4e-22 PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X5 [Tribolium castaneum]>gi|642939247|ref|XP_008194777.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X5 [Tribolium castaneum]>gi|642939249|ref|XP_008194778.1| PREDICTED: phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X5 [Tribolium castaneum] -- -- -- -- -- K04714 SGMS shingomyelin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K04714 Q9U3D4 200 6.9e-15 Phosphatidylcholine:ceramide cholinephosphotransferase 1 OS=Caenorhabditis elegans GN=sms-1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3058 Uncharacterized conserved protein Cluster-8309.55079 BF_2 73.69 1.12 3047 189236300 XP_001815376.1 2442 1.4e-272 PREDICTED: uncharacterized protein LOC100141693 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55080 BF_2 41.37 0.41 4474 642919497 XP_008191896.1 2883 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55081 BF_2 77.00 5.68 854 478259797 ENN79625.1 512 2.4e-49 hypothetical protein YQE_03914, partial [Dendroctonus ponderosae]>gi|478269270|gb|ENN83314.1| hypothetical protein YQE_00330, partial [Dendroctonus ponderosae] -- -- -- -- -- K14860 TMA16 translation machinery-associated protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K14860 Q9VXY4 343 3.8e-31 Translation machinery-associated protein 16 homolog OS=Drosophila melanogaster GN=CG15027 PE=2 SV=2 PF07743//PF04558 HSCB C-terminal oligomerisation domain//Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 GO:0006418//GO:0051259 tRNA aminoacylation for protein translation//protein oligomerization GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.55082 BF_2 177.57 1.67 4742 546686097 ERL95494.1 1149 1.8e-122 hypothetical protein D910_12756 [Dendroctonus ponderosae] 807033242 XM_004529566.2 72 2.03773e-26 PREDICTED: Ceratitis capitata TM2 domain-containing protein almondex (LOC101449885), mRNA -- -- -- -- Q9U4H5 645 2.0e-65 TM2 domain-containing protein almondex OS=Drosophila melanogaster GN=amx PE=2 SV=1 PF06743//PF05733 FAST kinase-like protein, subdomain 1//Tenuivirus/Phlebovirus nucleocapsid protein -- -- GO:0004672//GO:0003723 protein kinase activity//RNA binding GO:0019013 viral nucleocapsid KOG4272 Predicted GTP-binding protein Cluster-8309.55083 BF_2 45.00 0.66 3127 -- -- -- -- -- 462297252 APGK01052089.1 186 5.67994e-90 Dendroctonus ponderosae Seq01052099, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF06645 Microsomal signal peptidase 12 kDa subunit (SPC12) GO:0006465 signal peptide processing GO:0008233 peptidase activity GO:0005787//GO:0016021 signal peptidase complex//integral component of membrane -- -- Cluster-8309.55093 BF_2 316.00 2.61 5345 270006420 EFA02868.1 5545 0.0e+00 hypothetical protein TcasGA2_TC007861 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- F7J220 181 1.5e-11 Scavenger receptor cysteine-rich domain superfamily protein OS=Patiria pectinifera GN=SRCR1 PE=1 SV=1 PF15494//PF01245//PF02854//PF00530 Scavenger receptor cysteine-rich domain//Ribosomal protein L19//MIF4G domain//Scavenger receptor cysteine-rich domain GO:0006412//GO:0007165//GO:0042254 translation//signal transduction//ribosome biogenesis GO:0005515//GO:0005044//GO:0003723//GO:0003735 protein binding//scavenger receptor activity//RNA binding//structural constituent of ribosome GO:0005622//GO:0016020//GO:0005840 intracellular//membrane//ribosome -- -- Cluster-8309.55095 BF_2 147.65 4.95 1535 642914561 XP_008201730.1 474 1.1e-44 PREDICTED: uncharacterized protein LOC660094 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55098 BF_2 196.00 1.02 8323 642920424 XP_008192344.1 2195 1.6e-243 PREDICTED: fasciclin-2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1510 1.8e-165 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF05864//PF13895//PF07354//PF00041//PF16656 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Immunoglobulin domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006206//GO:0006771//GO:0019497//GO:0006144//GO:0007339//GO:0006351 pyrimidine nucleobase metabolic process//riboflavin metabolic process//hexachlorocyclohexane metabolic process//purine nucleobase metabolic process//binding of sperm to zona pellucida//transcription, DNA-templated GO:0046872//GO:0003993//GO:0005515//GO:0003677//GO:0003899 metal ion binding//acid phosphatase activity//protein binding//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0005576 nucleolus//extracellular region -- -- Cluster-8309.55099 BF_2 175.89 2.06 3858 642920424 XP_008192344.1 2430 4.2e-271 PREDICTED: fasciclin-2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1590 4.4e-175 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF05864//PF16656//PF07354//PF13895//PF00041 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Immunoglobulin domain//Fibronectin type III domain GO:0006771//GO:0006206//GO:0006144//GO:0007339//GO:0019497//GO:0006351 riboflavin metabolic process//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process//transcription, DNA-templated GO:0046872//GO:0003993//GO:0005515//GO:0003899//GO:0003677 metal ion binding//acid phosphatase activity//protein binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730//GO:0005576 nucleolus//extracellular region -- -- Cluster-8309.551 BF_2 22.00 0.68 1631 270004310 EFA00758.1 833 2.7e-86 hypothetical protein TcasGA2_TC003644 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DIM3 566 1.0e-56 Tubulin delta chain OS=Xenopus tropicalis GN=tubd1 PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1374 Gamma tubulin Cluster-8309.55100 BF_2 36.50 0.42 3966 642920420 XP_008192342.1 2610 5.8e-292 PREDICTED: fasciclin-2 isoform X1 [Tribolium castaneum] 642920419 XM_008194120.1 83 1.30624e-32 PREDICTED: Tribolium castaneum fasciclin-2 (LOC664545), transcript variant X1, mRNA K06491 NCAM neural cell adhesion molecule http://www.genome.jp/dbget-bin/www_bget?ko:K06491 P34082 1640 7.2e-181 Fasciclin-2 OS=Drosophila melanogaster GN=Fas2 PE=1 SV=1 PF16656//PF07354//PF00041//PF13895//PF05864 Purple acid Phosphatase, N-terminal domain//Zona-pellucida-binding protein (Sp38)//Fibronectin type III domain//Immunoglobulin domain//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) GO:0006771//GO:0006206//GO:0006351//GO:0006144//GO:0007339//GO:0019497 riboflavin metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//binding of sperm to zona pellucida//hexachlorocyclohexane metabolic process GO:0003993//GO:0046872//GO:0003899//GO:0003677//GO:0005515 acid phosphatase activity//metal ion binding//DNA-directed RNA polymerase activity//DNA binding//protein binding GO:0005576//GO:0005730 extracellular region//nucleolus -- -- Cluster-8309.55102 BF_2 41.39 1.15 1797 642919375 XP_008191845.1 373 6.5e-33 PREDICTED: vascular endothelial growth factor receptor 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26618 185 1.7e-12 Platelet-derived growth factor receptor alpha OS=Mus musculus GN=Pdgfra PE=1 SV=3 PF01325 Iron dependent repressor, N-terminal DNA binding domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.55105 BF_2 239.41 3.12 3502 646695578 KDR08392.1 995 9.6e-105 Ankyrin repeat domain-containing protein 29, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q502M6 578 8.9e-58 Ankyrin repeat domain-containing protein 29 OS=Danio rerio GN=ankrd29 PE=2 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55108 BF_2 2.00 0.51 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55109 BF_2 25.46 0.63 1986 270008606 EFA05054.1 1237 4.7e-133 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 485 3.1e-47 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.55111 BF_2 48.00 1.23 1923 270015255 EFA11703.1 629 1.4e-62 hypothetical protein TcasGA2_TC001790 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55113 BF_2 44.54 0.97 2205 270008606 EFA05054.1 1594 2.1e-174 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P20825 485 3.4e-47 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF08053 Tryptophanase operon leader peptide GO:0031554//GO:0031556 regulation of DNA-templated transcription, termination//transcriptional attenuation by ribosome -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.55118 BF_2 7.18 0.69 723 270005429 EFA01877.1 144 9.4e-07 hypothetical protein TcasGA2_TC007482 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55121 BF_2 235.70 2.78 3839 642937311 XP_008198781.1 2062 2.0e-228 PREDICTED: chondroitin sulfate N-acetylgalactosaminyltransferase 1 [Tribolium castaneum]>gi|642937313|ref|XP_008198782.1| PREDICTED: chondroitin sulfate N-acetylgalactosaminyltransferase 1 [Tribolium castaneum] 817208281 XM_012424720.1 287 4.99781e-146 PREDICTED: Orussus abietinus chondroitin sulfate N-acetylgalactosaminyltransferase 1 (LOC105699586), mRNA K00746 CSGALNACT1_2 chondroitin sulfate N-acetylgalactosaminyltransferase 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K00746 Q8N6G5 922 1.3e-97 Chondroitin sulfate N-acetylgalactosaminyltransferase 2 OS=Homo sapiens GN=CSGALNACT2 PE=1 SV=1 PF05679 Chondroitin N-acetylgalactosaminyltransferase -- -- GO:0008376 acetylgalactosaminyltransferase activity GO:0032580 Golgi cisterna membrane KOG3588 Chondroitin synthase 1 Cluster-8309.55122 BF_2 3.00 0.51 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55126 BF_2 9.27 0.54 1010 642921483 XP_008192888.1 430 9.0e-40 PREDICTED: uncharacterized protein LOC660985 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00939 Sodium:sulfate symporter transmembrane region GO:0006810//GO:0055085//GO:0006814 transport//transmembrane transport//sodium ion transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.55127 BF_2 12.19 0.65 1067 332027123 EGI67218.1 743 4.8e-76 FLJ37770-like protein, partial [Acromyrmex echinatior] 795011845 XM_012019428.1 678 0 PREDICTED: Vollenhovia emeryi putative uncharacterized protein FLJ37770 (LOC105565876), mRNA -- -- -- -- Q3ZCU0 256 5.9e-21 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 PF13443//PF02070 Cro/C1-type HTH DNA-binding domain//Neuromedin U GO:0006940 regulation of smooth muscle contraction GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.55132 BF_2 12.00 3.23 442 545205324 XP_005606371.1 395 4.5e-36 PREDICTED: fibroblast growth factor receptor 1 isoform X6 [Equus caballus] 188219627 NG_007729.1 442 0 Homo sapiens fibroblast growth factor receptor 1 (FGFR1), RefSeqGene on chromosome 8 K04362 FGFR1 fibroblast growth factor receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04362 P11362 392 4.1e-37 Fibroblast growth factor receptor 1 OS=Homo sapiens GN=FGFR1 PE=1 SV=3 PF13895//PF01513 Immunoglobulin domain//ATP-NAD kinase GO:0008152//GO:0006741//GO:0006769//GO:0046497 metabolic process//NADP biosynthetic process//nicotinamide metabolic process//nicotinate nucleotide metabolic process GO:0003951//GO:0005515 NAD+ kinase activity//protein binding -- -- -- -- Cluster-8309.55137 BF_2 1153.00 79.61 893 642921987 XP_008192971.1 360 1.0e-31 PREDICTED: uncharacterized protein LOC660232 [Tribolium castaneum]>gi|270007403|gb|EFA03851.1| hypothetical protein TcasGA2_TC013967 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55139 BF_2 88.89 0.58 6713 642924251 XP_008194216.1 4280 0.0e+00 PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924253|ref|XP_008194217.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924255|ref|XP_008194218.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum]>gi|642924257|ref|XP_008194219.1| PREDICTED: pleckstrin homology domain-containing family G member 5 isoform X1 [Tribolium castaneum] 755881777 XM_005185855.2 73 8.03486e-27 PREDICTED: Musca domestica N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein (LOC101896829), transcript variant X1, mRNA K03857 PIGA, GPI3 phosphatidylinositol glycan, class A http://www.genome.jp/dbget-bin/www_bget?ko:K03857 Q64323 1243 1.3e-134 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein OS=Mus musculus GN=Piga PE=2 SV=1 PF03790//PF08288//PF02196//PF00621 KNOX1 domain//PIGA (GPI anchor biosynthesis)//Raf-like Ras-binding domain//RhoGEF domain GO:0043087//GO:0006506//GO:0007165//GO:0035023 regulation of GTPase activity//GPI anchor biosynthetic process//signal transduction//regulation of Rho protein signal transduction GO:0005089//GO:0003677//GO:0005057 Rho guanyl-nucleotide exchange factor activity//DNA binding//receptor signaling protein activity GO:0005634 nucleus KOG1111 N-acetylglucosaminyltransferase complex, subunit PIG-A/SPT14, required for phosphatidylinositol biosynthesis/Sulfolipid synthase Cluster-8309.5514 BF_2 26.98 0.59 2200 270004851 EFA01299.1 2370 2.2e-264 hypothetical protein TcasGA2_TC003136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O70244 209 3.4e-15 Cubilin OS=Rattus norvegicus GN=Cubn PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55143 BF_2 70.00 8.59 628 91086345 XP_974310.1 234 3.0e-17 PREDICTED: uncharacterized protein LOC663157 [Tribolium castaneum]>gi|270009846|gb|EFA06294.1| hypothetical protein TcasGA2_TC009161 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55144 BF_2 68.51 0.67 4543 827546729 XP_012545763.1 260 2.1e-19 PREDICTED: uncharacterized protein LOC105841624 isoform X1 [Bombyx mori] -- -- -- -- -- -- -- -- -- P10394 136 2.1e-06 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF02251 Proteasome activator pa28 alpha subunit -- -- -- -- GO:0008537 proteasome activator complex -- -- Cluster-8309.55149 BF_2 43.26 0.33 5747 102939 188 5.9e-11 hypothetical protein 2 - cabbage looper transposon TED (fragment) -- -- -- -- -- -- -- -- -- -- -- -- -- PF00722 Glycosyl hydrolases family 16 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.55151 BF_2 4.00 0.80 497 270003164 EEZ99611.1 167 1.4e-09 hypothetical protein TcasGA2_TC002128 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.55159 BF_2 2.00 0.61 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55161 BF_2 38.46 3.67 726 546684200 ERL93905.1 256 9.7e-20 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55165 BF_2 25.47 0.82 1585 478257377 ENN77535.1 412 1.7e-37 hypothetical protein YQE_05983, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12142 Polyphenol oxidase middle domain GO:0006118//GO:0006570//GO:0055114 obsolete electron transport//tyrosine metabolic process//oxidation-reduction process GO:0004097 catechol oxidase activity -- -- -- -- Cluster-8309.55166 BF_2 174.98 10.85 962 478259434 ENN79324.1 586 7.0e-58 hypothetical protein YQE_04233, partial [Dendroctonus ponderosae]>gi|546675175|gb|ERL86411.1| hypothetical protein D910_03818 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55173 BF_2 171.00 2.25 3462 270005481 EFA01929.1 2901 0.0e+00 hypothetical protein TcasGA2_TC007543 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8I7P9 823 3.4e-86 Retrovirus-related Pol polyprotein from transposon opus OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF04926//PF00098//PF09668 Poly(A) polymerase predicted RNA binding domain//Zinc knuckle//Aspartyl protease GO:0043631//GO:0006508 RNA polyadenylation//proteolysis GO:0004190//GO:0003676//GO:0003723//GO:0008270 aspartic-type endopeptidase activity//nucleic acid binding//RNA binding//zinc ion binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.55174 BF_2 1.00 3.98 260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55176 BF_2 57.57 1.65 1743 642916148 XP_008190905.1 2133 5.2e-237 PREDICTED: BAI1-associated protein 3 [Tribolium castaneum]>gi|270003708|gb|EFA00156.1| hypothetical protein TcasGA2_TC002977 [Tribolium castaneum] 462300336 APGK01050985.1 87 3.39364e-35 Dendroctonus ponderosae Seq01050995, whole genome shotgun sequence K15621 BAIAP3 BAI1-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15621 O94812 603 5.6e-61 BAI1-associated protein 3 OS=Homo sapiens GN=BAIAP3 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1328 Synaptic vesicle protein BAIAP3, involved in vesicle priming/regulation Cluster-8309.55178 BF_2 374.55 13.33 1463 91085557 XP_966821.1 987 3.4e-104 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 409 1.5e-38 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13414//PF00254//PF13371//PF13181//PF00515 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.55180 BF_2 172.16 5.85 1519 91085557 XP_966821.1 987 3.5e-104 PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|642926957|ref|XP_008195078.1| PREDICTED: peptidyl-prolyl cis-trans isomerase FKBP8 [Tribolium castaneum]>gi|270010048|gb|EFA06496.1| hypothetical protein TcasGA2_TC009394 [Tribolium castaneum] -- -- -- -- -- K09574 FKBP8 FK506-binding protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K09574 O35465 409 1.5e-38 Peptidyl-prolyl cis-trans isomerase FKBP8 OS=Mus musculus GN=Fkbp8 PE=1 SV=2 PF13414//PF00254//PF13371//PF13181//PF00515 TPR repeat//FKBP-type peptidyl-prolyl cis-trans isomerase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006457 protein folding GO:0005515 protein binding -- -- KOG0543 FKBP-type peptidyl-prolyl cis-trans isomerase Cluster-8309.55188 BF_2 165.73 4.48 1833 91090512 XP_969653.1 942 7.0e-99 PREDICTED: transmembrane protein 177 [Tribolium castaneum]>gi|270013871|gb|EFA10319.1| hypothetical protein TcasGA2_TC012535 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q53S58 309 7.2e-27 Transmembrane protein 177 OS=Homo sapiens GN=TMEM177 PE=2 SV=1 PF02065 Melibiase GO:0006012//GO:0001575//GO:0046486//GO:0005975 galactose metabolic process//globoside metabolic process//glycerolipid metabolic process//carbohydrate metabolic process GO:0004557 alpha-galactosidase activity -- -- -- -- Cluster-8309.55193 BF_2 72.92 1.42 2438 642937199 XP_008198736.1 2686 5.5e-301 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha [Tribolium castaneum] 198463328 XM_001352749.2 66 2.25303e-23 Drosophila pseudoobscura pseudoobscura GA11104 (Dpse\GA11104), partial mRNA K00923 PIK3C2 phosphatidylinositol-4-phosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00923 O00443 1554 4.1e-171 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha OS=Homo sapiens GN=PIK3C2A PE=1 SV=2 PF00454//PF00787//PF00168 Phosphatidylinositol 3- and 4-kinase//PX domain//C2 domain -- -- GO:0035091//GO:0005515//GO:0016773 phosphatidylinositol binding//protein binding//phosphotransferase activity, alcohol group as acceptor -- -- KOG0905 Phosphoinositide 3-kinase Cluster-8309.55196 BF_2 51.00 1.77 1492 164698402 NP_001106938.1 1444 3.5e-157 optix [Tribolium castaneum]>gi|162417305|emb|CAP58434.1| Optix [Tribolium castaneum]>gi|270002745|gb|EEZ99192.1| sine oculis-related homeobox 3 [Tribolium castaneum] 683895024 XM_009101655.1 233 1.99841e-116 PREDICTED: Serinus canaria SIX homeobox 6 (SIX6), mRNA K19473 SIX3_6, OPTIX homeobox protein SIX3/6 http://www.genome.jp/dbget-bin/www_bget?ko:K19473 Q95RW8 905 4.6e-96 Protein Optix OS=Drosophila melanogaster GN=Optix PE=2 SV=1 PF05920//PF01381//PF00046 Homeobox KN domain//Helix-turn-helix//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- KOG0775 Transcription factor SIX and related HOX domain proteins Cluster-8309.55197 BF_2 29.00 1.56 1064 164698402 NP_001106938.1 237 2.3e-17 optix [Tribolium castaneum]>gi|162417305|emb|CAP58434.1| Optix [Tribolium castaneum]>gi|270002745|gb|EEZ99192.1| sine oculis-related homeobox 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5520 BF_2 26.71 2.33 767 642918110 XP_008194042.1 311 4.3e-26 PREDICTED: calpain-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K08583 CAPNS1, CAPN4 calpain, small subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08583 Q11002 280 7.0e-24 Calpain-A OS=Drosophila melanogaster GN=CalpA PE=1 SV=2 PF13499//PF13405//PF13833//PF00036//PF13202 EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//EF hand -- -- GO:0005509 calcium ion binding -- -- KOG0037 Ca2+-binding protein, EF-Hand protein superfamily Cluster-8309.55200 BF_2 22.61 0.57 1956 478260286 ENN80038.1 1121 1.3e-119 hypothetical protein YQE_03515, partial [Dendroctonus ponderosae] -- -- -- -- -- K03660 OGG1 N-glycosylase/DNA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K03660 O70249 689 6.7e-71 N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1 PF07934//PF00730//PF00633 8-oxoguanine DNA glycosylase, N-terminal domain//HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006289//GO:0006308//GO:0006285//GO:0006281//GO:0006284 nucleotide-excision repair//DNA catabolic process//base-excision repair, AP site formation//DNA repair//base-excision repair GO:0003684//GO:0008534//GO:0003677 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//DNA binding -- -- KOG2875 8-oxoguanine DNA glycosylase Cluster-8309.55201 BF_2 21.63 0.38 2671 478260286 ENN80038.1 1036 1.3e-109 hypothetical protein YQE_03515, partial [Dendroctonus ponderosae] -- -- -- -- -- K03660 OGG1 N-glycosylase/DNA lyase http://www.genome.jp/dbget-bin/www_bget?ko:K03660 O70249 633 2.8e-64 N-glycosylase/DNA lyase OS=Rattus norvegicus GN=Ogg1 PE=2 SV=1 PF13895//PF07934//PF00730//PF00633 Immunoglobulin domain//8-oxoguanine DNA glycosylase, N-terminal domain//HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006308//GO:0006289//GO:0006285//GO:0006281//GO:0006284 DNA catabolic process//nucleotide-excision repair//base-excision repair, AP site formation//DNA repair//base-excision repair GO:0003684//GO:0008534//GO:0005515//GO:0003677 damaged DNA binding//oxidized purine nucleobase lesion DNA N-glycosylase activity//protein binding//DNA binding -- -- KOG2875 8-oxoguanine DNA glycosylase Cluster-8309.55203 BF_2 17.00 1.53 751 675769308 XP_008974241.1 982 6.6e-104 PREDICTED: hamartin isoform X1 [Pan paniscus]>gi|675769311|ref|XP_008974242.1| PREDICTED: hamartin isoform X1 [Pan paniscus]>gi|675769314|ref|XP_008974243.1| PREDICTED: hamartin isoform X1 [Pan paniscus] 254039583 NG_012386.1 748 0 Homo sapiens tuberous sclerosis 1 (TSC1), RefSeqGene (LRG_486) on chromosome 9 K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q92574 982 2.7e-105 Hamartin OS=Homo sapiens GN=TSC1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55208 BF_2 80.91 0.59 5980 642924788 XP_008194040.1 2680 6.7e-300 PREDICTED: period isoform X1 [Tribolium castaneum] -- -- -- -- -- K02633 PER period circadian protein http://www.genome.jp/dbget-bin/www_bget?ko:K02633 Q25637 1503 8.3e-165 Period circadian protein OS=Periplaneta americana GN=per PE=2 SV=2 PF00516//PF08447//PF08926//PF00989//PF01554 Envelope glycoprotein GP120//PAS fold//Domain of unknown function (DUF1908)//PAS fold//MatE GO:0006355//GO:0055085//GO:0009069//GO:0006468//GO:0006810//GO:0015893//GO:0006855//GO:0016310 regulation of transcription, DNA-templated//transmembrane transport//serine family amino acid metabolic process//protein phosphorylation//transport//drug transport//drug transmembrane transport//phosphorylation GO:0004674//GO:0005524//GO:0015238//GO:0000287//GO:0015297//GO:0005515 protein serine/threonine kinase activity//ATP binding//drug transmembrane transporter activity//magnesium ion binding//antiporter activity//protein binding GO:0016020//GO:0019031 membrane//viral envelope KOG3753 Circadian clock protein period Cluster-8309.55210 BF_2 598.92 12.48 2294 189235467 XP_001814003.1 488 3.9e-46 PREDICTED: chymotrypsin-1 [Tribolium castaneum]>gi|270004829|gb|EFA01277.1| serine protease P40 [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q2KJ63 300 1.0e-25 Plasma kallikrein OS=Bos taurus GN=KLKB1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0003824//GO:0004252 catalytic activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.55211 BF_2 546.14 3.64 6560 642938343 XP_008192909.1 4571 0.0e+00 PREDICTED: uncharacterized protein LOC103312885 [Tribolium castaneum] -- -- -- -- -- K11494 RCBTB RCC1 and BTB domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K11494 Q5DX34 317 3.1e-27 X-linked retinitis pigmentosa GTPase regulator homolog OS=Caenorhabditis elegans GN=glo-4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.55213 BF_2 25.59 0.35 3320 270015450 EFA11898.1 580 1.2e-56 hypothetical protein TcasGA2_TC001429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00589 Phage integrase family GO:0006310//GO:0015074 DNA recombination//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.55215 BF_2 59.68 0.49 5369 751224154 XP_011165403.1 320 2.7e-26 PREDICTED: uncharacterized protein LOC105199832 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08103 Uperin family -- -- -- -- GO:0005576 extracellular region -- -- Cluster-8309.55219 BF_2 32.38 0.78 2030 642930150 XP_008196273.1 1005 3.8e-106 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X7 [Tribolium castaneum] 189164165 EU545256.1 262 2.07089e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 753 2.6e-78 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.55220 BF_2 48.83 0.31 6954 91078738 XP_967649.1 297 1.6e-23 PREDICTED: desumoylating isopeptidase 2 [Tribolium castaneum]>gi|270004090|gb|EFA00538.1| hypothetical protein TcasGA2_TC003403 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC39 181 1.9e-11 Desumoylating isopeptidase 2 OS=Danio rerio GN=desi2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0324 Uncharacterized conserved protein Cluster-8309.55229 BF_2 91.57 0.49 8101 642934007 XP_008197600.1 1043 6.0e-110 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] 584600633 EU595402.2 44 1.2824e-10 Drosophila virilis kl-2 1-beta dynein heavy chain mRNA, partial cds K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 735 1.3e-75 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF03028//PF01467//PF02993//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//Minor capsid protein VI//EGF-like domain GO:0007018//GO:0007017//GO:0009058 microtubule-based movement//microtubule-based process//biosynthetic process GO:0003824//GO:0003777//GO:0005515 catalytic activity//microtubule motor activity//protein binding GO:0019028//GO:0030286//GO:0005874 viral capsid//dynein complex//microtubule KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.55231 BF_2 49.50 3.17 941 642938130 XP_008199777.1 688 1.0e-69 PREDICTED: inositol monophosphatase 1 isoform X3 [Tribolium castaneum] -- -- -- -- -- K01092 E3.1.3.25, IMPA, suhB myo-inositol-1(or 4)-monophosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01092 Q5R4X0 449 2.2e-43 Inositol monophosphatase 1 OS=Pongo abelii GN=IMPA1 PE=2 SV=1 PF02399//PF00459 Origin of replication binding protein//Inositol monophosphatase family GO:0006260//GO:0046854 DNA replication//phosphatidylinositol phosphorylation GO:0005524//GO:0003688 ATP binding//DNA replication origin binding GO:0046809 replication compartment KOG2951 Inositol monophosphatase Cluster-8309.55232 BF_2 519.89 17.70 1516 546681588 ERL91652.1 2079 8.3e-231 hypothetical protein D910_08980 [Dendroctonus ponderosae] 642933909 XM_966503.2 342 5.18816e-177 PREDICTED: Tribolium castaneum pontin (LOC660254), mRNA K04499 RUVBL1, RVB1, INO80H RuvB-like protein 1 (pontin 52) http://www.genome.jp/dbget-bin/www_bget?ko:K04499 Q0IFL2 1883 1.8e-209 RuvB-like helicase 1 OS=Aedes aegypti GN=pont PE=3 SV=1 PF00004//PF01695//PF14532//PF07728//PF01057//PF05496//PF03796//PF00158//PF06068//PF02562//PF04851//PF02367//PF06414 ATPase family associated with various cellular activities (AAA)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//DnaB-like helicase C terminal domain//Sigma-54 interaction domain//TIP49 C-terminus//PhoH-like protein//Type III restriction enzyme, res subunit//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin GO:0006310//GO:0002949//GO:0006355//GO:0006260//GO:0019079//GO:0006281 DNA recombination//tRNA threonylcarbamoyladenosine modification//regulation of transcription, DNA-templated//DNA replication//viral genome replication//DNA repair GO:0009378//GO:0003678//GO:0003677//GO:0016887//GO:0016301//GO:0005524//GO:0016787//GO:0008134 four-way junction helicase activity//DNA helicase activity//DNA binding//ATPase activity//kinase activity//ATP binding//hydrolase activity//transcription factor binding GO:0005657//GO:0005667//GO:0009379 replication fork//transcription factor complex//Holliday junction helicase complex KOG1942 DNA helicase, TBP-interacting protein Cluster-8309.55233 BF_2 44.69 3.65 800 642920190 XP_008192241.1 430 7.1e-40 PREDICTED: protein lin-52 homolog [Tribolium castaneum]>gi|270005293|gb|EFA01741.1| hypothetical protein TcasGA2_TC007337 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0AUQ6 254 7.5e-21 Protein lin-52 homolog OS=Danio rerio GN=lin52 PE=3 SV=1 PF10044 Retinal tissue protein GO:0006351//GO:0007049 transcription, DNA-templated//cell cycle -- -- GO:0070176 DRM complex -- -- Cluster-8309.55234 BF_2 141.51 3.44 2010 478255734 ENN75943.1 592 3.0e-58 hypothetical protein YQE_07478, partial [Dendroctonus ponderosae]>gi|546683611|gb|ERL93399.1| hypothetical protein D910_10691 [Dendroctonus ponderosae] -- -- -- -- -- K13403 MTHFD2 methylenetetrahydrofolate dehydrogenase(NAD+) / 5,10-methenyltetrahydrofolate cyclohydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K13403 Q5ZKA5 483 5.3e-47 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial OS=Gallus gallus GN=MTHFD2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0089 Methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase Cluster-8309.55236 BF_2 24.13 1.03 1268 642932698 XP_008196949.1 688 1.4e-69 PREDICTED: uncharacterized protein LOC660251 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06371//PF06367 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain GO:0030036//GO:0016043 actin cytoskeleton organization//cellular component organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- -- -- Cluster-8309.55238 BF_2 8.93 0.31 1509 642929040 XP_008195665.1 469 4.1e-44 PREDICTED: uncharacterized protein LOC662520 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 1.1e-07 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55240 BF_2 21.88 0.31 3257 642940154 XP_008194847.1 1148 1.6e-122 PREDICTED: myoneurin-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 335 1.2e-29 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF02714//PF00651 Calcium-dependent channel, 7TM region, putative phosphate//BTB/POZ domain -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.55245 BF_2 35.00 0.37 4246 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55246 BF_2 19.71 0.71 1450 752863505 XP_011268107.1 284 1.1e-22 PREDICTED: myb/SANT-like DNA-binding domain-containing protein 4 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q9CR78 182 3.0e-12 Myb/SANT-like DNA-binding domain-containing protein 3 OS=Mus musculus GN=Msantd3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55247 BF_2 52.86 1.21 2121 91075962 XP_969092.1 1413 2.0e-153 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1185 2.2e-128 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF04851//PF09177//PF07517//PF00270 Type III restriction enzyme, res subunit//Syntaxin 6, N-terminal//SecA DEAD-like domain//DEAD/DEAH box helicase GO:0048193//GO:0017038 Golgi vesicle transport//protein import GO:0005524//GO:0016787//GO:0003677//GO:0003676 ATP binding//hydrolase activity//DNA binding//nucleic acid binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.5525 BF_2 10.23 0.33 1593 642937652 XP_966876.3 304 5.8e-25 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P243 175 2.2e-11 Zinc finger protein ZFAT OS=Homo sapiens GN=ZFAT PE=1 SV=2 PF00096//PF02416 Zinc finger, C2H2 type//mttA/Hcf106 family GO:0015031 protein transport GO:0008565//GO:0046872 protein transporter activity//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.55256 BF_2 10.00 0.80 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55257 BF_2 10.37 0.31 1685 91086187 XP_971225.1 429 2.0e-39 PREDICTED: JNK1/MAPK8-associated membrane protein [Tribolium castaneum]>gi|270010234|gb|EFA06682.1| hypothetical protein TcasGA2_TC009612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9P055 298 1.3e-25 JNK1/MAPK8-associated membrane protein OS=Homo sapiens GN=JKAMP PE=2 SV=2 PF07925 Reovirus RNA-dependent RNA polymerase lambda 3 GO:0006144//GO:0032774 purine nucleobase metabolic process//RNA biosynthetic process GO:0003968//GO:0003723 RNA-directed RNA polymerase activity//RNA binding GO:0031379//GO:0019013 RNA-directed RNA polymerase complex//viral nucleocapsid -- -- Cluster-8309.55258 BF_2 529.00 11.06 2288 91082769 XP_973660.1 2460 8.3e-275 PREDICTED: probable peroxisomal acyl-coenzyme A oxidase 1 [Tribolium castaneum]>gi|270015082|gb|EFA11530.1| hypothetical protein TcasGA2_TC014245 [Tribolium castaneum] -- -- -- -- -- K00232 E1.3.3.6, ACOX1, ACOX3 acyl-CoA oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00232 Q7KML2 1770 3.5e-196 Probable peroxisomal acyl-coenzyme A oxidase 1 OS=Drosophila melanogaster GN=CG5009 PE=1 SV=1 PF01756//PF00441//PF02770 Acyl-CoA oxidase//Acyl-CoA dehydrogenase, C-terminal domain//Acyl-CoA dehydrogenase, middle domain GO:0055114//GO:0006118//GO:0006635//GO:0006637 oxidation-reduction process//obsolete electron transport//fatty acid beta-oxidation//acyl-CoA metabolic process GO:0016627//GO:0050660//GO:0003997//GO:0003995 oxidoreductase activity, acting on the CH-CH group of donors//flavin adenine dinucleotide binding//acyl-CoA oxidase activity//acyl-CoA dehydrogenase activity GO:0005777 peroxisome KOG0136 Acyl-CoA oxidase Cluster-8309.55259 BF_2 5.00 0.54 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55261 BF_2 36.00 2.57 874 -- -- -- -- -- 428674401 JQ694715.1 874 0 Oryza sativa Japonica Group glutelin (GluB) mRNA, partial cds -- -- -- -- Q6ERU3 1086 2.8e-117 Glutelin type-B 5 OS=Oryza sativa subsp. japonica GN=GLUB5 PE=2 SV=1 PF03079//PF00190 ARD/ARD' family//Cupin GO:0055114 oxidation-reduction process GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity -- -- -- -- Cluster-8309.55262 BF_2 56.71 0.61 4201 270010376 EFA06824.1 2606 1.8e-291 hypothetical protein TcasGA2_TC009766 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13590 263 3.6e-21 Neural cell adhesion molecule 1 OS=Gallus gallus GN=NCAM1 PE=1 SV=3 PF02480//PF00041//PF13895//PF15880 Alphaherpesvirus glycoprotein E//Fibronectin type III domain//Immunoglobulin domain//NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial -- -- GO:0005515 protein binding GO:0016020//GO:0005747//GO:0005739 membrane//mitochondrial respiratory chain complex I//mitochondrion -- -- Cluster-8309.55268 BF_2 96.81 4.08 1280 91087755 XP_974940.1 1296 4.4e-140 PREDICTED: protein FAM50 homolog [Tribolium castaneum]>gi|270009391|gb|EFA05839.1| hypothetical protein TcasGA2_TC008623 [Tribolium castaneum] 766921690 XM_011507073.1 204 2.25634e-100 PREDICTED: Ceratosolen solmsi marchali protein FAM50 homolog (LOC105368137), transcript variant X3, mRNA K13119 FAM50, XAP5 protein FAM50 http://www.genome.jp/dbget-bin/www_bget?ko:K13119 Q299F9 1119 6.0e-121 Protein FAM50 homolog OS=Drosophila pseudoobscura pseudoobscura GN=GA11514 PE=3 SV=1 PF02196//PF04921 Raf-like Ras-binding domain//XAP5, circadian clock regulator GO:0007165 signal transduction GO:0005057 receptor signaling protein activity GO:0005634 nucleus KOG2894 Uncharacterized conserved protein XAP-5 Cluster-8309.55270 BF_2 10.25 0.40 1351 642928603 XP_008199974.1 477 4.3e-45 PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum]>gi|642928605|ref|XP_008199975.1| PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum]>gi|642928607|ref|XP_008199976.1| PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum]>gi|642928609|ref|XP_008199977.1| PREDICTED: glucose-dependent insulinotropic receptor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6XXX9 139 2.7e-07 5-hydroxytryptamine receptor 1A OS=Canis familiaris GN=HTR1A PE=3 SV=1 PF05434//PF00895//PF00001//PF07127 TMEM9//ATP synthase protein 8//7 transmembrane receptor (rhodopsin family)//Late nodulin protein GO:0007186//GO:0009878//GO:0015986//GO:0015992 G-protein coupled receptor signaling pathway//nodule morphogenesis//ATP synthesis coupled proton transport//proton transport GO:0004930//GO:0015078//GO:0046872 G-protein coupled receptor activity//hydrogen ion transmembrane transporter activity//metal ion binding GO:0016021//GO:0000276 integral component of membrane//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.55272 BF_2 2.00 1.92 321 307187889 EFN72812.1 136 3.5e-06 hypothetical protein EAG_02637, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55273 BF_2 4.80 0.35 855 642927688 XP_008196543.1 453 1.6e-42 PREDICTED: acidic leucine-rich nuclear phosphoprotein 32 family member A isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C6G1 248 4.0e-20 Protein C21orf2 homolog OS=Mus musculus PE=2 SV=1 PF02038//PF02179//PF13855//PF13516 ATP1G1/PLM/MAT8 family//BAG domain//Leucine rich repeat//Leucine Rich repeat GO:0006811 ion transport GO:0051087//GO:0005216//GO:0005515 chaperone binding//ion channel activity//protein binding GO:0016020 membrane KOG2123 Uncharacterized conserved protein Cluster-8309.55275 BF_2 298.50 11.21 1401 478259261 ENN79163.1 473 1.3e-44 hypothetical protein YQE_04348, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13903//PF07062 PMP-22/EMP/MP20/Claudin tight junction//Clc-like -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.55278 BF_2 65.00 1.09 2786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55279 BF_2 48.00 1.57 1566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55280 BF_2 12.11 0.46 1391 546684929 ERL94511.1 162 1.5e-08 hypothetical protein D910_11788 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776 Zinc-finger associated domain (zf-AD) -- -- GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.55281 BF_2 19.24 0.51 1855 332374316 AEE62299.1 329 8.5e-28 unknown [Dendroctonus ponderosae]>gi|478255157|gb|ENN75386.1| hypothetical protein YQE_07938, partial [Dendroctonus ponderosae]>gi|546677194|gb|ERL88076.1| hypothetical protein D910_05465 [Dendroctonus ponderosae] -- -- -- -- -- K01764 E4.4.1.17 cytochrome c heme-lyase http://www.genome.jp/dbget-bin/www_bget?ko:K01764 Q5F339 142 1.7e-07 Cytochrome c-type heme lyase OS=Gallus gallus GN=HCCS PE=2 SV=1 PF01265 Cytochrome c/c1 heme lyase GO:0015994 chlorophyll metabolic process GO:0004408 holocytochrome-c synthase activity GO:0005739 mitochondrion KOG3996 Holocytochrome c synthase/heme-lyase Cluster-8309.55283 BF_2 34.84 1.19 1513 534293303 AGU16824.1 1225 8.8e-132 S-adenosyl- L-homocysteine hydrolase [Leptinotarsa decemlineata]>gi|859132839|gb|AKO63328.1| S-adenosylhomocysteine hydrolase 2 [Leptinotarsa decemlineata] 821118450 XM_004463226.2 126 6.1358e-57 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 O43865 1075 9.0e-116 Adenosylhomocysteinase 2 OS=Homo sapiens GN=AHCYL1 PE=1 SV=2 PF02882//PF02826//PF13241//PF16683//PF07851//PF00208//PF02254//PF07992//PF05221//PF02966 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Putative NAD(P)-binding//Transglutaminase elicitor//TMPIT-like protein//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//TrkA-N domain//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//Mitosis protein DIM1 GO:0006730//GO:0000398//GO:0006779//GO:0055114//GO:0009396//GO:0046487//GO:0006555//GO:0006520//GO:0019354//GO:0006813 one-carbon metabolic process//mRNA splicing, via spliceosome//porphyrin-containing compound biosynthetic process//oxidation-reduction process//folic acid-containing compound biosynthetic process//glyoxylate metabolic process//methionine metabolic process//cellular amino acid metabolic process//siroheme biosynthetic process//potassium ion transport GO:0016755//GO:0004488//GO:0043115//GO:0003824//GO:0016491//GO:0004013//GO:0051287 transferase activity, transferring amino-acyl groups//methylenetetrahydrofolate dehydrogenase (NADP+) activity//precorrin-2 dehydrogenase activity//catalytic activity//oxidoreductase activity//adenosylhomocysteinase activity//NAD binding GO:0016021//GO:0005681 integral component of membrane//spliceosomal complex KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.55285 BF_2 3.80 0.50 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55288 BF_2 3.00 0.38 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55289 BF_2 703.50 15.93 2135 546681664 ERL91712.1 1305 6.6e-141 hypothetical protein D910_09039 [Dendroctonus ponderosae] -- -- -- -- -- K15280 SLC35C2 solute carrier family 35, member C2 http://www.genome.jp/dbget-bin/www_bget?ko:K15280 Q9NQQ7 658 2.9e-67 Solute carrier family 35 member C2 OS=Homo sapiens GN=SLC35C2 PE=1 SV=2 PF00892 EamA-like transporter family -- -- -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1443 Predicted integral membrane protein Cluster-8309.55293 BF_2 83.95 1.95 2091 642933178 XP_008197290.1 1648 1.1e-180 PREDICTED: G protein-activated inward rectifier potassium channel 3-like isoform X2 [Tribolium castaneum] 430763429 JQ753065.1 49 5.43606e-14 Aedes aegypti strain Liverpool Kir1 channel protein mRNA, complete cds K05330 KCNJN potassium inwardly-rectifying channel subfamily J, other http://www.genome.jp/dbget-bin/www_bget?ko:K05330 Q92806 911 1.3e-96 G protein-activated inward rectifier potassium channel 3 OS=Homo sapiens GN=KCNJ9 PE=2 SV=2 PF01007//PF00520//PF10716 Inward rectifier potassium channel//Ion transport protein//NADH dehydrogenase transmembrane subunit GO:0006811//GO:0055114//GO:0006118//GO:0006813//GO:0055085 ion transport//oxidation-reduction process//obsolete electron transport//potassium ion transport//transmembrane transport GO:0016655//GO:0005216//GO:0005242 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//ion channel activity//inward rectifier potassium channel activity GO:0008076//GO:0016020//GO:0016021 voltage-gated potassium channel complex//membrane//integral component of membrane KOG3827 Inward rectifier K+ channel Cluster-8309.55296 BF_2 67.64 1.47 2208 91082417 XP_970245.1 740 2.2e-75 PREDICTED: CXXC-type zinc finger protein 1 [Tribolium castaneum]>gi|270007163|gb|EFA03611.1| hypothetical protein TcasGA2_TC013699 [Tribolium castaneum] -- -- -- -- -- K14960 CXXC1, SPP1, CPS40 COMPASS component SPP1 http://www.genome.jp/dbget-bin/www_bget?ko:K14960 Q9W352 344 7.6e-31 CXXC-type zinc finger protein 1 OS=Drosophila melanogaster GN=Cfp1 PE=1 SV=1 PF00628//PF02008//PF07690//PF00083 PHD-finger//CXXC zinc finger domain//Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0003677//GO:0022857//GO:0008270//GO:0046872//GO:0005515 DNA binding//transmembrane transporter activity//zinc ion binding//metal ion binding//protein binding GO:0016021 integral component of membrane KOG1632 Uncharacterized PHD Zn-finger protein Cluster-8309.55298 BF_2 84.60 3.60 1271 642931053 XP_973827.2 1132 4.5e-121 PREDICTED: isoaspartyl peptidase/L-asparaginase [Tribolium castaneum] -- -- -- -- -- K13051 iaaA, ASRGL1 beta-aspartyl-peptidase (threonine type) http://www.genome.jp/dbget-bin/www_bget?ko:K13051 Q29I93 723 4.9e-75 Probable isoaspartyl peptidase/L-asparaginase GA20639 OS=Drosophila pseudoobscura pseudoobscura GN=GA20639 PE=3 SV=1 PF01112 Asparaginase -- -- GO:0016787 hydrolase activity -- -- KOG1592 Asparaginase Cluster-8309.55301 BF_2 157.63 1.97 3628 642929960 XP_008196043.1 1073 8.9e-114 PREDICTED: uncharacterized protein LOC661554 [Tribolium castaneum] -- -- -- -- -- K07819 B3GALT1 beta-1,3-galactosyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07819 O54904 431 1.0e-40 Beta-1,3-galactosyltransferase 1 OS=Mus musculus GN=B3galt1 PE=2 SV=2 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane -- -- Cluster-8309.55302 BF_2 24.32 0.95 1353 642921027 XP_008192660.1 749 1.2e-76 PREDICTED: protein kinase C-binding protein NELL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A5Y0 275 4.7e-23 Protein kinase C-binding protein NELL2 OS=Danio rerio GN=nell2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55304 BF_2 87.00 2.92 1533 546680804 ERL91010.1 1646 1.4e-180 hypothetical protein D910_08352 [Dendroctonus ponderosae] -- -- -- -- -- K16943 SEPT4 septin 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16943 Q5R6R7 1146 5.3e-124 Septin-4 OS=Pongo abelii GN=SEPT4 PE=2 SV=1 PF02421//PF01926//PF08477//PF00735//PF00071//PF04548//PF03193//PF00005 Ferrous iron transport protein B//50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//Ras family//AIG1 family//Protein of unknown function, DUF258//ABC transporter GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0005525//GO:0016887//GO:0005524//GO:0015093//GO:0003924 GTP binding//ATPase activity//ATP binding//ferrous iron transmembrane transporter activity//GTPase activity GO:0016021 integral component of membrane -- -- Cluster-8309.55309 BF_2 485.64 10.09 2301 478258940 ENN78915.1 1193 6.9e-128 hypothetical protein YQE_04628, partial [Dendroctonus ponderosae]>gi|546675357|gb|ERL86567.1| hypothetical protein D910_03974 [Dendroctonus ponderosae] -- -- -- -- -- K19269 PGP, PGLP phosphoglycolate phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19269 Q8CHP8 606 3.3e-61 Phosphoglycolate phosphatase OS=Mus musculus GN=Pgp PE=1 SV=1 PF03767 HAD superfamily, subfamily IIIB (Acid phosphatase) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.5531 BF_2 7.30 0.36 1133 270012930 EFA09378.1 160 2.1e-08 hypothetical protein TcasGA2_TC001939 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02214 BTB/POZ domain GO:0051260 protein homooligomerization -- -- -- -- -- -- Cluster-8309.55313 BF_2 4.95 0.32 936 642916163 XP_008190912.1 310 6.9e-26 PREDICTED: abhydrolase domain-containing protein 16A [Tribolium castaneum]>gi|270003703|gb|EFA00151.1| hypothetical protein TcasGA2_TC002972 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O95870 172 2.8e-11 Abhydrolase domain-containing protein 16A OS=Homo sapiens GN=ABHD16A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55314 BF_2 10.00 0.81 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55315 BF_2 5.31 0.58 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF10766 Multidrug efflux pump-associated protein AcrZ GO:0015893//GO:0006855 drug transport//drug transmembrane transport GO:0015238 drug transmembrane transporter activity GO:0005886 plasma membrane -- -- Cluster-8309.55316 BF_2 58.08 0.68 3873 91092132 XP_975744.1 3438 0.0e+00 PREDICTED: transportin-1 [Tribolium castaneum] 641677337 XM_001948935.3 163 4.30394e-77 PREDICTED: Acyrthosiphon pisum transportin-1 (LOC100169518), mRNA K18752 TNPO1 transportin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K18752 Q8BFY9 3032 0.0e+00 Transportin-1 OS=Mus musculus GN=Tnpo1 PE=1 SV=2 PF02985//PF03810//PF01602//PF00514 HEAT repeat//Importin-beta N-terminal domain//Adaptin N terminal region//Armadillo/beta-catenin-like repeat GO:0016192//GO:0006886 vesicle-mediated transport//intracellular protein transport GO:0008536//GO:0005515 Ran GTPase binding//protein binding GO:0030117 membrane coat KOG2023 Nuclear transport receptor Karyopherin-beta2/Transportin (importin beta superfamily) Cluster-8309.55317 BF_2 8.00 3.71 375 820999335 XP_012354788.1 342 5.4e-30 PREDICTED: mast/stem cell growth factor receptor Kit isoform X1 [Nomascus leucogenys] 170014706 NG_007456.1 375 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P10721 342 2.2e-31 Mast/stem cell growth factor receptor Kit OS=Homo sapiens GN=KIT PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55321 BF_2 585.50 12.46 2253 270014745 EFA11193.1 1460 7.4e-159 hypothetical protein TcasGA2_TC004801 [Tribolium castaneum] 642911832 XM_008202543.1 270 8.22242e-137 PREDICTED: Tribolium castaneum endophilin-A (LOC661913), transcript variant X2, mRNA K11247 SH3GL endophilin-A http://www.genome.jp/dbget-bin/www_bget?ko:K11247 Q8I190 1146 7.8e-124 Endophilin-A OS=Drosophila virilis GN=endoA PE=3 SV=1 PF03114 BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG1118 Lysophosphatidic acid acyltransferase endophilin/SH3GL, involved in synaptic vesicle formation Cluster-8309.55325 BF_2 102.24 2.85 1789 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55327 BF_2 55.58 0.62 4028 270003759 EFA00207.1 1136 4.9e-121 hypothetical protein TcasGA2_TC003032 [Tribolium castaneum] 642915871 XM_008198084.1 73 4.80606e-27 PREDICTED: Tribolium castaneum ataxin-1 (LOC103313823), transcript variant X4, mRNA -- -- -- -- P54253 359 2.5e-32 Ataxin-1 OS=Homo sapiens GN=ATXN1 PE=1 SV=2 PF08517 Ataxin-1 and HBP1 module (AXH) -- -- GO:0003723//GO:0005515 RNA binding//protein binding -- -- KOG4053 Ataxin-1, involved in Ca2+ homeostasis Cluster-8309.55330 BF_2 5.70 0.71 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55331 BF_2 3.00 0.37 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55340 BF_2 1.00 3.32 266 728417870 AIY68350.1 329 1.2e-28 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K12298 CEL bile salt-stimulated lipase http://www.genome.jp/dbget-bin/www_bget?ko:K12298 P30122 279 3.1e-24 Bile salt-activated lipase (Fragment) OS=Bos taurus GN=CEL PE=1 SV=2 PF07859//PF00326 alpha/beta hydrolase fold//Prolyl oligopeptidase family GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008236//GO:0016787 serine-type peptidase activity//hydrolase activity -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.55341 BF_2 35.93 1.09 1665 546671622 ERL83856.1 140 6.3e-06 hypothetical protein D910_01123 [Dendroctonus ponderosae]>gi|546672359|gb|ERL84263.1| hypothetical protein D910_01644 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05434//PF10717//PF06687//PF11837//PF05399//PF09480 TMEM9//Occlusion-derived virus envelope protein ODV-E18//SUR7/PalI family//Domain of unknown function (DUF3357)//Ectropic viral integration site 2A protein (EVI2A)//Type III secretion system protein PrgH-EprH (PrgH) GO:0006012//GO:0005985//GO:0005982 galactose metabolic process//sucrose metabolic process//starch metabolic process GO:0004564//GO:0004575 beta-fructofuranosidase activity//sucrose alpha-glucosidase activity GO:0005886//GO:0016021//GO:0017177//GO:0019031 plasma membrane//integral component of membrane//glucosidase II complex//viral envelope -- -- Cluster-8309.55343 BF_2 3.00 0.34 660 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55344 BF_2 26.59 1.76 920 808147467 XP_012174812.1 762 2.6e-78 PREDICTED: potassium channel subfamily T member 2 isoform X1 [Bombus terrestris]>gi|808147469|ref|XP_012174813.1| PREDICTED: potassium channel subfamily T member 2 isoform X1 [Bombus terrestris] 755849387 XM_011295091.1 96 1.74854e-40 PREDICTED: Musca domestica potassium channel subfamily T member 2 (LOC101895809), transcript variant X3, mRNA K04946 KCNT1 potassium channel subfamily T member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04946 Q5JUK3 376 6.2e-35 Potassium channel subfamily T member 1 OS=Homo sapiens GN=KCNT1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55348 BF_2 39.66 1.17 1706 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55355 BF_2 107.07 1.39 3505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00443 Ubiquitin carboxyl-terminal hydrolase GO:0016579 protein deubiquitination GO:0036459 ubiquitinyl hydrolase activity -- -- -- -- Cluster-8309.55358 BF_2 25.89 0.53 2320 642916559 XP_008191693.1 1581 7.1e-173 PREDICTED: uncharacterized protein LOC103312554 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55359 BF_2 779.00 63.18 818 546683574 ERL93372.1 514 1.3e-49 hypothetical protein D910_10664 [Dendroctonus ponderosae] -- -- -- -- -- K09621 KLK12 kallikrein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09621 Q00871 423 1.9e-40 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.55361 BF_2 2.01 1.64 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55362 BF_2 114.39 1.89 2813 91089975 XP_973865.1 663 2.4e-66 PREDICTED: glycolipid transfer protein [Tribolium castaneum]>gi|270013545|gb|EFA09993.1| hypothetical protein TcasGA2_TC012160 [Tribolium castaneum] -- -- -- -- -- K01512 acyP acylphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K01512 D3ZY60 238 1.9e-18 Pleckstrin homology domain-containing family A member 8 OS=Rattus norvegicus GN=Plekha8 PE=1 SV=1 PF08718 Glycolipid transfer protein (GLTP) GO:0046836 glycolipid transport GO:0051861//GO:0017089 glycolipid binding//glycolipid transporter activity GO:0005737 cytoplasm KOG3221 Glycolipid transfer protein Cluster-8309.55368 BF_2 34.90 0.36 4366 189233937 XP_973896.2 1951 1.7e-215 PREDICTED: conserved oligomeric Golgi complex subunit 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T322 638 1.2e-64 N-alpha-acetyltransferase 35, NatC auxiliary subunit OS=Danio rerio GN=naa35 PE=2 SV=1 PF02050//PF08336//PF08287//PF01442 Flagellar FliJ protein//Prolyl 4-Hydroxylase alpha-subunit, N-terminal region//Spc19//Apolipoprotein A1/A4/E domain GO:0042157//GO:0006935//GO:0006560//GO:0006869//GO:0071973//GO:0018401//GO:0006525//GO:0008608//GO:0055114 lipoprotein metabolic process//chemotaxis//proline metabolic process//lipid transport//bacterial-type flagellum-dependent cell motility//peptidyl-proline hydroxylation to 4-hydroxy-L-proline//arginine metabolic process//attachment of spindle microtubules to kinetochore//oxidation-reduction process GO:0008289//GO:0004656//GO:0003774//GO:0016702 lipid binding//procollagen-proline 4-dioxygenase activity//motor activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen GO:0005783//GO:0016020//GO:0005576//GO:0009288//GO:0042729//GO:0005876 endoplasmic reticulum//membrane//extracellular region//bacterial-type flagellum//DASH complex//spindle microtubule KOG2343 Glucose-repressible protein and related proteins Cluster-8309.55369 BF_2 25.29 1.76 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55370 BF_2 57.16 0.53 4832 270000843 EEZ97290.1 1515 6.6e-165 hypothetical protein TcasGA2_TC011095 [Tribolium castaneum] 642937273 XM_008200545.1 236 1.41344e-117 PREDICTED: Tribolium castaneum PH and SEC7 domain-containing protein 1 (LOC657863), transcript variant X2, mRNA K12494 PSD PH and SEC7 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12494 Q2PFD7 763 4.3e-79 PH and SEC7 domain-containing protein 3 OS=Mus musculus GN=Psd3 PE=1 SV=2 PF16867//PF01369 Dimethlysulfonioproprionate lyase//Sec7 domain GO:0032012//GO:0043087 regulation of ARF protein signal transduction//regulation of GTPase activity GO:0005086//GO:0047869 ARF guanyl-nucleotide exchange factor activity//dimethylpropiothetin dethiomethylase activity -- -- KOG0932 Guanine nucleotide exchange factor EFA6 Cluster-8309.55372 BF_2 108.00 0.78 6087 642913346 XP_967720.2 5481 0.0e+00 PREDICTED: chaoptin [Tribolium castaneum]>gi|270002774|gb|EEZ99221.1| hypothetical protein TcasGA2_TC000625 [Tribolium castaneum] 759033122 XM_011346822.1 60 1.22768e-19 PREDICTED: Cerapachys biroi chaoptin-like (LOC105283719), transcript variant X2, mRNA -- -- -- -- P12024 466 1.5e-44 Chaoptin OS=Drosophila melanogaster GN=chp PE=1 SV=2 PF00560//PF13855//PF00041 Leucine Rich Repeat//Leucine rich repeat//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.55373 BF_2 78.46 0.57 6087 270003815 EFA00263.1 2255 1.3e-250 hypothetical protein TcasGA2_TC003096 [Tribolium castaneum] 769847817 XM_011636959.1 159 1.13577e-74 PREDICTED: Pogonomyrmex barbatus adenylate cyclase type 2 (LOC105425936), transcript variant X4, mRNA K08042 ADCY2 adenylate cyclase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K08042 Q9VW60 1530 6.3e-168 Adenylate cyclase type 2 OS=Drosophila melanogaster GN=Ac76E PE=2 SV=3 PF13465//PF06327//PF02674//PF07701//PF00211 Zinc-finger double domain//Domain of Unknown Function (DUF1053)//Colicin V production protein//Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain GO:0009190//GO:0035556//GO:0046039//GO:0006182//GO:0009403//GO:0006144//GO:0006171 cyclic nucleotide biosynthetic process//intracellular signal transduction//GTP metabolic process//cGMP biosynthetic process//toxin biosynthetic process//purine nucleobase metabolic process//cAMP biosynthetic process GO:0004383//GO:0016849//GO:0004016//GO:0046872 guanylate cyclase activity//phosphorus-oxygen lyase activity//adenylate cyclase activity//metal ion binding GO:0016020//GO:0005886 membrane//plasma membrane -- -- Cluster-8309.55374 BF_2 69.69 0.76 4143 642913995 XP_008201506.1 1146 3.5e-122 PREDICTED: uncharacterized protein CG1785 isoform X1 [Tribolium castaneum]>gi|270001623|gb|EEZ98070.1| hypothetical protein TcasGA2_TC000477 [Tribolium castaneum] -- -- -- -- -- K14825 ERP2 protein ERP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14825 Q9W3C2 663 1.5e-67 Uncharacterized protein CG1785 OS=Drosophila melanogaster GN=CG1785 PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG2823 Cellular protein (glioma tumor suppressor candidate region gene 2) Cluster-8309.55375 BF_2 401.31 4.07 4412 642913995 XP_008201506.1 1173 2.8e-125 PREDICTED: uncharacterized protein CG1785 isoform X1 [Tribolium castaneum]>gi|270001623|gb|EEZ98070.1| hypothetical protein TcasGA2_TC000477 [Tribolium castaneum] -- -- -- -- -- K14825 ERP2 protein ERP2 http://www.genome.jp/dbget-bin/www_bget?ko:K14825 Q9W3C2 678 2.8e-69 Uncharacterized protein CG1785 OS=Drosophila melanogaster GN=CG1785 PE=2 SV=1 PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane KOG2823 Cellular protein (glioma tumor suppressor candidate region gene 2) Cluster-8309.55378 BF_2 76.04 12.93 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55383 BF_2 29.57 1.68 1022 91088039 XP_974446.1 529 3.0e-51 PREDICTED: erlin-1 [Tribolium castaneum]>gi|270012079|gb|EFA08527.1| hypothetical protein TcasGA2_TC006180 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q91X78 463 5.6e-45 Erlin-1 OS=Mus musculus GN=Erlin1 PE=1 SV=1 PF00318 Ribosomal protein S2 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG2962 Prohibitin-related membrane protease subunits Cluster-8309.55384 BF_2 60.94 0.40 6634 642916934 XP_008199560.1 959 2.7e-100 PREDICTED: serine/threonine-protein kinase HSL1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07578 Lipid A Biosynthesis N-terminal domain GO:0009245 lipid A biosynthetic process GO:0008915 lipid-A-disaccharide synthase activity -- -- -- -- Cluster-8309.55386 BF_2 25.10 0.36 3208 642928537 XP_008195365.1 949 1.9e-99 PREDICTED: serine protease easter-like [Tribolium castaneum]>gi|270011008|gb|EFA07456.1| serine protease P95 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 441 6.3e-42 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF07167 Trypsin//Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus GO:0042619//GO:0006508 poly-hydroxybutyrate biosynthetic process//proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.55390 BF_2 112.00 2.19 2426 478262400 ENN81071.1 841 4.8e-87 hypothetical protein YQE_02440, partial [Dendroctonus ponderosae]>gi|546673620|gb|ERL85184.1| hypothetical protein D910_02606 [Dendroctonus ponderosae] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q91YN5 675 3.5e-69 UDP-N-acetylhexosamine pyrophosphorylase OS=Mus musculus GN=Uap1 PE=1 SV=1 PF01704//PF05388//PF06344 UTP--glucose-1-phosphate uridylyltransferase//Carboxypeptidase Y pro-peptide//Parechovirus Genome-linked protein GO:0008152 metabolic process GO:0004185//GO:0070569 serine-type carboxypeptidase activity//uridylyltransferase activity GO:0005773//GO:0019015 vacuole//viral genome KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.55391 BF_2 37.98 1.03 1832 270011556 EFA08004.1 719 5.0e-73 hypothetical protein TcasGA2_TC005593 [Tribolium castaneum] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q7ZWD4 549 1.1e-54 UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 OS=Danio rerio GN=uap1l1 PE=2 SV=1 PF07657//PF01704 N terminus of Notch ligand//UTP--glucose-1-phosphate uridylyltransferase GO:0007219//GO:0008152//GO:0007275 Notch signaling pathway//metabolic process//multicellular organismal development GO:0070569 uridylyltransferase activity GO:0016021 integral component of membrane KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.55396 BF_2 36.25 0.50 3309 642937864 XP_008200330.1 2824 0.0e+00 PREDICTED: protein FAM91A1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TEP1 1762 4.3e-195 Protein FAM91A1 OS=Danio rerio GN=fam91a1 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3707 Uncharacterized conserved protein Cluster-8309.55397 BF_2 4.00 0.33 791 546673338 ERL84964.1 240 7.6e-18 hypothetical protein D910_02387 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55399 BF_2 13.84 1.25 751 270001219 EEZ97666.1 524 8.4e-51 hypothetical protein TcasGA2_TC016211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9FN05 393 5.4e-37 Probable glucan 1,3-alpha-glucosidase OS=Arabidopsis thaliana GN=PSL5 PE=1 SV=1 PF00834//PF01055 Ribulose-phosphate 3 epimerase family//Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553//GO:0016857 hydrolase activity, hydrolyzing O-glycosyl compounds//racemase and epimerase activity, acting on carbohydrates and derivatives -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.554 BF_2 7.11 0.32 1212 189237943 XP_001811459.1 935 3.0e-98 PREDICTED: WD repeat domain-containing protein 83 [Tribolium castaneum] -- -- -- -- -- K13124 MORG1 mitogen-activated protein kinase organizer 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13124 Q9DAJ4 686 9.2e-71 WD repeat domain-containing protein 83 OS=Mus musculus GN=Wdr83 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0316 Conserved WD40 repeat-containing protein Cluster-8309.55400 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55406 BF_2 5.00 0.40 810 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55410 BF_2 46.81 0.35 5911 102939 1614 2.7e-176 hypothetical protein 2 - cabbage looper transposon TED (fragment) 667676433 AE013599.5 36 2.61693e-06 Drosophila melanogaster chromosome 2R -- -- -- -- P04323 1273 3.9e-138 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.55411 BF_2 49.31 0.37 5896 130405 P04323.1 1232 5.3e-132 RecName: Full=Retrovirus-related Pol polyprotein from transposon 17.6; Includes: RecName: Full=Protease; Includes: RecName: Full=Reverse transcriptase; Includes: RecName: Full=Endonuclease [Drosophila melanogaster]>gi|1335613|emb|CAA25702.1| unnamed protein product [Drosophila melanogaster]>gi|224319|prf||1101404B ORF 2 667676433 AE013599.5 36 2.61025e-06 Drosophila melanogaster chromosome 2R -- -- -- -- P04323 1232 2.2e-133 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.55414 BF_2 108.72 1.36 3633 642910790 XP_008193412.1 598 1.1e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P35779 409 3.6e-38 Venom allergen 3 OS=Solenopsis richteri PE=1 SV=2 PF05434 TMEM9 -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.55422 BF_2 38.56 0.80 2310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55423 BF_2 152.76 3.75 1991 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55425 BF_2 10.27 0.36 1475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55426 BF_2 19.78 0.42 2239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06881 RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.55427 BF_2 52.90 1.61 1662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06881 RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated -- -- GO:0016021//GO:0005634 integral component of membrane//nucleus -- -- Cluster-8309.5543 BF_2 136.66 3.39 1973 91086385 XP_974771.1 2431 1.6e-271 PREDICTED: MAU2 chromatid cohesion factor homolog [Tribolium castaneum]>gi|270010289|gb|EFA06737.1| hypothetical protein TcasGA2_TC009670 [Tribolium castaneum] 808124960 XR_001098858.1 264 1.55515e-133 PREDICTED: Bombus terrestris MAU2 chromatid cohesion factor homolog (LOC100648021), transcript variant X3, misc_RNA K11266 MAU2 MAternally affected uncoordination http://www.genome.jp/dbget-bin/www_bget?ko:K11266 B1H1Z8 1672 7.0e-185 MAU2 chromatid cohesion factor homolog OS=Xenopus tropicalis GN=mau2 PE=2 SV=1 PF00515//PF13374//PF13181//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0005515 protein binding -- -- KOG2300 Uncharacterized conserved protein Cluster-8309.55431 BF_2 45.47 0.34 5853 642928417 XP_008193778.1 489 7.5e-46 PREDICTED: transcriptional regulator ATRX homolog isoform X1 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 Q61687 350 4.1e-31 Transcriptional regulator ATRX OS=Mus musculus GN=Atrx PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.55432 BF_2 139.39 0.60 9930 642928419 XP_008193779.1 1636 1.3e-178 PREDICTED: transcriptional regulator ATRX homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- K10779 ATRX transcriptional regulator ATRX http://www.genome.jp/dbget-bin/www_bget?ko:K10779 F4HW51 979 8.0e-104 Protein CHROMATIN REMODELING 20 OS=Arabidopsis thaliana GN=ATRX PE=2 SV=2 PF00176//PF02729 SNF2 family N-terminal domain//Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain GO:0006520 cellular amino acid metabolic process GO:0016743//GO:0005524 carboxyl- or carbamoyltransferase activity//ATP binding -- -- KOG1015 Transcription regulator XNP/ATRX, DEAD-box superfamily Cluster-8309.55433 BF_2 34.68 5.01 577 642918847 XP_008191612.1 143 9.8e-07 PREDICTED: uncharacterized protein LOC661835 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55434 BF_2 21.00 0.53 1959 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00434 Glycoprotein VP7 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.55435 BF_2 27.06 0.90 1548 91080243 XP_976399.1 204 2.2e-13 PREDICTED: uncharacterized protein LOC661835 isoform X2 [Tribolium castaneum]>gi|270005622|gb|EFA02070.1| hypothetical protein TcasGA2_TC007704 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.55436 BF_2 22.07 0.63 1754 642918847 XP_008191612.1 214 1.7e-14 PREDICTED: uncharacterized protein LOC661835 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55437 BF_2 47.98 1.43 1692 642918847 XP_008191612.1 214 1.7e-14 PREDICTED: uncharacterized protein LOC661835 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55438 BF_2 192.44 3.03 2941 189233695 XP_001812208.1 494 1.0e-46 PREDICTED: serine-arginine protein 55-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12893 SFRS4_5_6 splicing factor, arginine/serine-rich 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K12893 P26686 369 1.3e-33 Serine-arginine protein 55 OS=Drosophila melanogaster GN=B52 PE=1 SV=4 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0106 Alternative splicing factor SRp55/B52/SRp75 (RRM superfamily) Cluster-8309.55439 BF_2 5.00 0.33 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55441 BF_2 5.00 0.55 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55442 BF_2 3.00 1.18 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55443 BF_2 59.52 3.52 994 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55445 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55446 BF_2 1.00 1.52 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55448 BF_2 3.00 1.21 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55450 BF_2 1.22 1.63 303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55454 BF_2 32.85 0.75 2126 642914318 XP_008201631.1 925 7.6e-97 PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914320|ref|XP_974744.2| PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914322|ref|XP_008201632.1| PREDICTED: F-box only protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZN4 300 9.3e-26 F-box only protein 6 OS=Mus musculus GN=Fbxo6 PE=1 SV=1 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55455 BF_2 60.81 0.66 4122 478255924 ENN76126.1 1002 1.7e-105 hypothetical protein YQE_07346, partial [Dendroctonus ponderosae]>gi|546676527|gb|ERL87521.1| hypothetical protein D910_04913 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q1DH70 815 3.4e-85 Innexin shaking-B OS=Aedes aegypti GN=shakB PE=3 SV=1 PF06753//PF00876 Bradykinin//Innexin GO:0006950//GO:0007165 response to stress//signal transduction GO:0005179 hormone activity GO:0005921//GO:0005576 gap junction//extracellular region -- -- Cluster-8309.55456 BF_2 2.00 0.95 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55459 BF_2 4.00 0.73 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55461 BF_2 3.00 0.37 630 642938407 XP_008191056.1 231 6.7e-17 PREDICTED: protein unc-80 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55464 BF_2 323.00 9.11 1770 -- -- -- -- -- 156764691 AK288076.1 1754 0 Oryza sativa Japonica Group cDNA, clone: J075163P08, full insert sequence -- -- -- -- P07730 2453 1.7e-275 Glutelin type-A 2 OS=Oryza sativa subsp. japonica GN=GLUA2 PE=1 SV=1 PF03079//PF00190 ARD/ARD' family//Cupin GO:0055114 oxidation-reduction process GO:0010309//GO:0045735 acireductone dioxygenase [iron(II)-requiring] activity//nutrient reservoir activity -- -- -- -- Cluster-8309.55473 BF_2 40.81 10.27 453 270007317 EFA03765.1 175 1.5e-10 hypothetical protein TcasGA2_TC013876 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55476 BF_2 6.54 0.57 769 642935085 XP_008197878.1 277 3.8e-22 PREDICTED: calmodulin-binding transcription activator 2-like isoform X4 [Tribolium castaneum] 642935084 XM_008199656.1 77 5.2914e-30 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- -- -- -- -- PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.55480 BF_2 108.95 1.09 4460 642914196 XP_008201585.1 3974 0.0e+00 PREDICTED: uncharacterized protein LOC661711 isoform X1 [Tribolium castaneum] 642914197 XM_008203364.1 679 0 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.8e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF04904//PF00018//PF15360//PF00536//PF07647 NAB conserved region 1 (NCD1)//SH3 domain//APJ endogenous ligand//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0007165//GO:0045892 signal transduction//negative regulation of transcription, DNA-templated GO:0005515//GO:0005179//GO:0031704 protein binding//hormone activity//apelin receptor binding GO:0005634 nucleus -- -- Cluster-8309.55484 BF_2 106.45 3.40 1595 642923720 XP_008193855.1 248 1.8e-18 PREDICTED: extended synaptotagmin-2 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7ZWU7 137 5.5e-07 Extended synaptotagmin-2-B OS=Xenopus laevis GN=esyt2-b PE=2 SV=1 PF17047 Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289 lipid binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.55490 BF_2 180.77 2.64 3150 91077384 XP_975249.1 1307 5.7e-141 PREDICTED: protoporphyrinogen oxidase [Tribolium castaneum]>gi|270001648|gb|EEZ98095.1| hypothetical protein TcasGA2_TC000508 [Tribolium castaneum] -- -- -- -- -- K00231 PPOX, hemY oxygen-dependent protoporphyrinogen oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00231 P51175 757 1.4e-78 Protoporphyrinogen oxidase OS=Mus musculus GN=Ppox PE=1 SV=1 PF00070//PF01593//PF12831//PF07992//PF02269//PF01266 Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Transcription initiation factor IID, 18kD subunit//FAD dependent oxidoreductase GO:0008152//GO:0006366//GO:0055114 metabolic process//transcription from RNA polymerase II promoter//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3901 Transcription initiation factor IID subunit Cluster-8309.55493 BF_2 1.00 4.65 255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55494 BF_2 114.80 0.99 5116 642931650 XP_008196671.1 3492 0.0e+00 PREDICTED: death-associated protein kinase 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O44997 892 5.0e-94 Death-associated protein kinase dapk-1 OS=Caenorhabditis elegans GN=dapk-1 PE=2 SV=2 PF04558//PF00583//PF13508//PF00023//PF08477//PF00531//PF13606 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//Ankyrin repeat//Ras of Complex, Roc, domain of DAPkinase//Death domain//Ankyrin repeat GO:0007165//GO:0042967//GO:0006418//GO:0007264 signal transduction//acyl-carrier-protein biosynthetic process//tRNA aminoacylation for protein translation//small GTPase mediated signal transduction GO:0005524//GO:0008080//GO:0005515//GO:0005525//GO:0000166//GO:0004812 ATP binding//N-acetyltransferase activity//protein binding//GTP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.55497 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55498 BF_2 89.46 1.36 3032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55501 BF_2 17.17 0.60 1490 546673224 ERL84874.1 303 7.1e-25 hypothetical protein D910_02297, partial [Dendroctonus ponderosae] 704338400 XM_010176089.1 39 1.39346e-08 PREDICTED: Caprimulgus carolinensis salvador family WW domain containing protein 1 (SAV1), mRNA K16686 SAV1, Sav scaffold protein salvador http://www.genome.jp/dbget-bin/www_bget?ko:K16686 Q8VEB2 252 2.4e-20 Protein salvador homolog 1 OS=Mus musculus GN=Sav1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0940 Ubiquitin protein ligase RSP5/NEDD4 Cluster-8309.55506 BF_2 28.75 2.24 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55508 BF_2 185.00 2.07 4032 642919331 XP_008191828.1 2203 9.2e-245 PREDICTED: phosphatidylinositol-binding clathrin assembly protein LAP-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VI75 1468 6.4e-161 Phosphatidylinositol-binding clathrin assembly protein LAP OS=Drosophila melanogaster GN=lap PE=1 SV=3 PF07651//PF13417//PF05434 ANTH domain//Glutathione S-transferase, N-terminal domain//TMEM9 -- -- GO:0005515//GO:0005543 protein binding//phospholipid binding GO:0016021 integral component of membrane KOG0251 Clathrin assembly protein AP180 and related proteins, contain ENTH domain Cluster-8309.55509 BF_2 43.78 3.73 778 195117344 XP_002003207.1 173 4.4e-10 GI17786 [Drosophila mojavensis]>gi|193913782|gb|EDW12649.1| GI17786 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07648//PF00050 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55510 BF_2 316.42 1.83 7538 642932112 XP_008196860.1 3146 0.0e+00 PREDICTED: ABC transporter G family member 14 isoform X1 [Tribolium castaneum] 642932111 XM_008198638.1 779 0 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X1, mRNA -- -- -- -- Q6WV17 1239 4.3e-134 Polypeptide N-acetylgalactosaminyltransferase 5 OS=Drosophila melanogaster GN=pgant5 PE=2 SV=2 PF01061//PF01926//PF13304//PF00004//PF00437//PF01637//PF00005//PF05418//PF03193//PF00910//PF10662 ABC-2 type transporter//50S ribosome-binding GTPase//AAA domain, putative AbiEii toxin, Type IV TA system//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Archaeal ATPase//ABC transporter//Apovitellenin I (Apo-VLDL-II)//Protein of unknown function, DUF258//RNA helicase//Ethanolamine utilisation - propanediol utilisation GO:0006629//GO:0006810//GO:0006576 lipid metabolic process//transport//cellular biogenic amine metabolic process GO:0004857//GO:0003924//GO:0003723//GO:0005524//GO:0003724//GO:0005525//GO:0016887 enzyme inhibitor activity//GTPase activity//RNA binding//ATP binding//RNA helicase activity//GTP binding//ATPase activity GO:0042627//GO:0016020 chylomicron//membrane KOG3736 Polypeptide N-acetylgalactosaminyltransferase Cluster-8309.55512 BF_2 44.36 0.86 2448 91086341 XP_974258.1 361 2.2e-31 PREDICTED: uncharacterized protein LOC663104 [Tribolium castaneum]>gi|270010276|gb|EFA06724.1| hypothetical protein TcasGA2_TC009655 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55514 BF_2 5.30 0.33 950 817197061 XP_012274135.1 418 2.1e-38 PREDICTED: electroneutral sodium bicarbonate exchanger 1 [Orussus abietinus] -- -- -- -- -- K13861 SLC4A10, NCBE solute carrier family 4 (sodium bicarbonate transporter), member 10 http://www.genome.jp/dbget-bin/www_bget?ko:K13861 Q8BTY2 220 7.8e-17 Sodium bicarbonate cotransporter 3 OS=Mus musculus GN=Slc4a7 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1172 Na+-independent Cl/HCO3 exchanger AE1 and related transporters (SLC4 family) Cluster-8309.55515 BF_2 4.00 0.53 602 768427743 XP_011554977.1 236 1.7e-17 PREDICTED: uncharacterized protein LOC105386168 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.55517 BF_2 69.54 0.35 8512 91078526 XP_970233.1 5708 0.0e+00 PREDICTED: mediator of RNA polymerase II transcription subunit 23 [Tribolium castaneum]>gi|270004027|gb|EFA00475.1| hypothetical protein TcasGA2_TC003334 [Tribolium castaneum] 572317849 XM_006624450.1 60 1.71894e-19 PREDICTED: Apis dorsata mediator of RNA polymerase II transcription subunit 23-like (LOC102675667), transcript variant X4, mRNA K15166 MED23 mediator of RNA polymerase II transcription subunit 23 http://www.genome.jp/dbget-bin/www_bget?ko:K15166 Q16HH9 3738 0.0e+00 Mediator of RNA polymerase II transcription subunit 23 OS=Aedes aegypti GN=MED23 PE=3 SV=1 PF16692//PF00472//PF00400//PF01059 Folliculin C-terminal domain//RF-1 domain//WD domain, G-beta repeat//NADH-ubiquinone oxidoreductase chain 4, amino terminus GO:0006415//GO:0043087//GO:0055114//GO:0006449//GO:0006120 translational termination//regulation of GTPase activity//oxidation-reduction process//regulation of translational termination//mitochondrial electron transport, NADH to ubiquinone GO:0005085//GO:0003747//GO:0005515 guanyl-nucleotide exchange factor activity//translation release factor activity//protein binding GO:0005840//GO:0018444 ribosome//translation release factor complex KOG3154 Uncharacterized conserved protein Cluster-8309.55518 BF_2 6.00 0.94 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55523 BF_2 136.18 4.77 1481 91082853 XP_970517.1 882 5.1e-92 PREDICTED: glyoxylate/hydroxypyruvate reductase A HPR2 [Tribolium castaneum]>gi|270007596|gb|EFA04044.1| hypothetical protein TcasGA2_TC014276 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32HN5 262 1.6e-21 Glyoxylate/hydroxypyruvate reductase A OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=ghrA PE=3 SV=2 PF02826//PF00365//PF03446 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Phosphofructokinase//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0019521//GO:0006094//GO:0006000//GO:0006013//GO:0055114//GO:0006012//GO:0006098//GO:0006096 D-gluconate metabolic process//gluconeogenesis//fructose metabolic process//mannose metabolic process//oxidation-reduction process//galactose metabolic process//pentose-phosphate shunt//glycolytic process GO:0004616//GO:0003872//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//6-phosphofructokinase activity//NAD binding GO:0005945 6-phosphofructokinase complex KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.55524 BF_2 23.82 0.80 1527 91082853 XP_970517.1 783 1.6e-80 PREDICTED: glyoxylate/hydroxypyruvate reductase A HPR2 [Tribolium castaneum]>gi|270007596|gb|EFA04044.1| hypothetical protein TcasGA2_TC014276 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q32HN5 223 5.6e-17 Glyoxylate/hydroxypyruvate reductase A OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=ghrA PE=3 SV=2 PF03435//PF03446//PF00365//PF02826 Saccharopine dehydrogenase NADP binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//Phosphofructokinase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0019521//GO:0006094//GO:0006000//GO:0006013//GO:0055114//GO:0006012//GO:0006098//GO:0006096 D-gluconate metabolic process//gluconeogenesis//fructose metabolic process//mannose metabolic process//oxidation-reduction process//galactose metabolic process//pentose-phosphate shunt//glycolytic process GO:0004616//GO:0003872//GO:0016491//GO:0051287 phosphogluconate dehydrogenase (decarboxylating) activity//6-phosphofructokinase activity//oxidoreductase activity//NAD binding GO:0005945 6-phosphofructokinase complex KOG0069 Glyoxylate/hydroxypyruvate reductase (D-isomer-specific 2-hydroxy acid dehydrogenase superfamily) Cluster-8309.55530 BF_2 16.25 1.13 889 91076372 XP_967795.1 905 6.6e-95 PREDICTED: palmitoyltransferase ZDHHC6 [Tribolium castaneum] 871251020 XM_005104281.2 41 6.33197e-10 PREDICTED: Aplysia californica palmitoyltransferase ZDHHC6-like (LOC101847980), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9H6R6 483 2.3e-47 Palmitoyltransferase ZDHHC6 OS=Homo sapiens GN=ZDHHC6 PE=1 SV=1 PF01529//PF00672//PF00033 DHHC palmitoyltransferase//HAMP domain//Cytochrome b/b6/petB GO:0022904//GO:0007165 respiratory electron transport chain//signal transduction GO:0004871//GO:0008270 signal transducer activity//zinc ion binding GO:0016020//GO:0016021 membrane//integral component of membrane KOG1314 DHHC-type Zn-finger protein Cluster-8309.55531 BF_2 4.00 0.45 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55534 BF_2 24.32 0.32 3460 478250209 ENN70712.1 1705 4.4e-187 hypothetical protein YQE_12657, partial [Dendroctonus ponderosae]>gi|546683975|gb|ERL93709.1| hypothetical protein D910_10996 [Dendroctonus ponderosae] -- -- -- -- -- K14807 DDX51, DBP6 ATP-dependent RNA helicase DDX51/DBP6 http://www.genome.jp/dbget-bin/www_bget?ko:K14807 P26802 957 9.9e-102 Probable ATP-dependent RNA helicase Dbp73D OS=Drosophila melanogaster GN=Dbp73D PE=2 SV=3 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0005524//GO:0016787//GO:0003677//GO:0003676 ATP binding//hydrolase activity//DNA binding//nucleic acid binding -- -- KOG0350 DEAD-box ATP-dependent RNA helicase Cluster-8309.55536 BF_2 19.34 0.46 2062 91087311 XP_975575.1 960 6.4e-101 PREDICTED: phosphorylated adapter RNA export protein [Tribolium castaneum]>gi|270009528|gb|EFA05976.1| hypothetical protein TcasGA2_TC008802 [Tribolium castaneum] -- -- -- -- -- K14291 PHAX phosphorylated adapter RNA export protein http://www.genome.jp/dbget-bin/www_bget?ko:K14291 Q5ZLY0 263 1.8e-21 Phosphorylated adapter RNA export protein OS=Gallus gallus GN=PHAX PE=2 SV=1 PF02269//PF09415 Transcription initiation factor IID, 18kD subunit//CENP-S associating Centromere protein X GO:0006366//GO:0006281//GO:0051382 transcription from RNA polymerase II promoter//DNA repair//kinetochore assembly -- -- -- -- KOG3948 Mediator of U snRNA nuclear export PHAX Cluster-8309.55537 BF_2 60.42 0.61 4449 642935794 XP_008198177.1 369 4.7e-32 PREDICTED: CD63 antigen-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335//PF00864 Tetraspanin family//ATP P2X receptor GO:0007165//GO:0033198//GO:0098655//GO:0006812 signal transduction//response to ATP//cation transmembrane transport//cation transport GO:0004931//GO:0001614 extracellular ATP-gated cation channel activity//purinergic nucleotide receptor activity GO:0005887//GO:0016021 integral component of plasma membrane//integral component of membrane -- -- Cluster-8309.55538 BF_2 121.86 2.75 2140 642914318 XP_008201631.1 924 1.0e-96 PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914320|ref|XP_974744.2| PREDICTED: F-box only protein 6 [Tribolium castaneum]>gi|642914322|ref|XP_008201632.1| PREDICTED: F-box only protein 6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZN4 300 9.3e-26 F-box only protein 6 OS=Mus musculus GN=Fbxo6 PE=1 SV=1 PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55539 BF_2 13.00 1.23 728 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55540 BF_2 25.36 0.94 1413 826409641 XP_012534005.1 166 5.2e-09 PREDICTED: uncharacterized protein LOC105835358, partial [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55541 BF_2 106.03 0.94 4989 642932250 XP_008197031.1 2707 4.1e-303 PREDICTED: archipelago isoform X1 [Tribolium castaneum]>gi|642932252|ref|XP_008197033.1| PREDICTED: archipelago isoform X1 [Tribolium castaneum]>gi|270012799|gb|EFA09247.1| archipelago [Tribolium castaneum] 642932251 XM_008198811.1 516 0 PREDICTED: Tribolium castaneum archipelago (ago), transcript variant X2, mRNA K10260 FBXW7, SEL10 F-box and WD-40 domain protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10260 Q9VZF4 2155 1.7e-240 F-box/WD repeat-containing protein 7 OS=Drosophila melanogaster GN=ago PE=1 SV=1 PF12937//PF00400//PF00646//PF06881 F-box-like//WD domain, G-beta repeat//F-box domain//RNA polymerase II transcription factor SIII (Elongin) subunit A GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.55542 BF_2 175.33 1.58 4935 642932250 XP_008197031.1 2707 4.1e-303 PREDICTED: archipelago isoform X1 [Tribolium castaneum]>gi|642932252|ref|XP_008197033.1| PREDICTED: archipelago isoform X1 [Tribolium castaneum]>gi|270012799|gb|EFA09247.1| archipelago [Tribolium castaneum] 642932251 XM_008198811.1 516 0 PREDICTED: Tribolium castaneum archipelago (ago), transcript variant X2, mRNA K10260 FBXW7, SEL10 F-box and WD-40 domain protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10260 Q9VZF4 2155 1.7e-240 F-box/WD repeat-containing protein 7 OS=Drosophila melanogaster GN=ago PE=1 SV=1 PF06881//PF00400//PF00646//PF12937 RNA polymerase II transcription factor SIII (Elongin) subunit A//WD domain, G-beta repeat//F-box domain//F-box-like GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.55548 BF_2 359.44 14.80 1303 553832058 AGY61427.1 1655 1.0e-181 photosystem II D1 protein [Lotharella sp. CCMP622] 42409130 AP005483.3 1303 0 Oryza sativa Japonica Group genomic DNA, chromosome 8, BAC clone:B1144B06 -- -- -- -- P0C434 1782 8.1e-198 Photosystem II protein D1 OS=Oryza sativa subsp. japonica GN=psbA PE=3 SV=1 PF00124 Photosynthetic reaction centre protein GO:0006118//GO:0009772//GO:0019684 obsolete electron transport//photosynthetic electron transport in photosystem II//photosynthesis, light reaction GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity -- -- -- -- Cluster-8309.55549 BF_2 82.56 3.57 1255 553832058 AGY61427.1 1655 1.0e-181 photosystem II D1 protein [Lotharella sp. CCMP622] 761231605 KM881639.1 1020 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q06H17 1783 6.0e-198 Photosystem II protein D1 OS=Drimys granadensis GN=psbA PE=3 SV=1 PF00124 Photosynthetic reaction centre protein GO:0006118//GO:0019684//GO:0009772 obsolete electron transport//photosynthesis, light reaction//photosynthetic electron transport in photosystem II GO:0045156 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity -- -- -- -- Cluster-8309.55551 BF_2 2.00 1.68 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55552 BF_2 332.04 5.78 2689 189235467 XP_001814003.1 660 5.1e-66 PREDICTED: chymotrypsin-1 [Tribolium castaneum]>gi|270004829|gb|EFA01277.1| serine protease P40 [Tribolium castaneum] -- -- -- -- -- K09635 TMPRSS4 transmembrane protease, serine 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09635 Q7SIG2 428 1.7e-40 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252//GO:0008233 serine-type endopeptidase activity//peptidase activity -- -- -- -- Cluster-8309.55554 BF_2 13.10 0.57 1247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55555 BF_2 34.62 0.87 1944 478258231 ENN78360.1 145 1.9e-06 hypothetical protein YQE_05162, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55557 BF_2 21.33 0.79 1416 478258231 ENN78360.1 145 1.4e-06 hypothetical protein YQE_05162, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55558 BF_2 9.08 0.60 917 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55561 BF_2 157.00 1.22 5652 270003200 EEZ99647.1 708 2.9e-71 hypothetical protein TcasGA2_TC002404 [Tribolium castaneum] -- -- -- -- -- K16768 CEP350 centrosomal protein CEP350 http://www.genome.jp/dbget-bin/www_bget?ko:K16768 Q5VT06 264 3.7e-21 Centrosome-associated protein 350 OS=Homo sapiens GN=CEP350 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55568 BF_2 122.53 5.65 1195 478259087 ENN79022.1 1292 1.2e-139 hypothetical protein YQE_04524, partial [Dendroctonus ponderosae] 195495253 XM_002095152.1 81 4.98904e-32 Drosophila yakuba GE22259 (Dyak\GE22259), partial mRNA -- -- -- -- Q9P2F6 235 1.8e-18 Rho GTPase-activating protein 20 OS=Homo sapiens GN=ARHGAP20 PE=1 SV=2 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.55571 BF_2 1.53 2.24 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55573 BF_2 1.00 9.73 234 390357282 XP_003728972.1 209 8.7e-15 PREDICTED: ankyrin repeat domain-containing protein 50-like [Strongylocentrotus purpuratus] -- -- -- -- -- K06270 PPP1R12A, MYPT1 protein phosphatase 1 regulatory subunit 12A http://www.genome.jp/dbget-bin/www_bget?ko:K06270 Q4UMH6 157 3.9e-10 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF03137//PF00023//PF13606 Organic Anion Transporter Polypeptide (OATP) family//Ankyrin repeat//Ankyrin repeat GO:0006810 transport GO:0005515//GO:0005215 protein binding//transporter activity GO:0016020 membrane KOG0505 Myosin phosphatase, regulatory subunit Cluster-8309.55575 BF_2 10.40 0.38 1445 478263063 ENN81463.1 393 2.5e-35 hypothetical protein YQE_02155, partial [Dendroctonus ponderosae] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 Q23979 204 8.5e-15 Myosin-IB OS=Drosophila melanogaster GN=Myo61F PE=1 SV=3 PF06017 Unconventional myosin tail, actin- and lipid-binding -- -- GO:0003774 motor activity GO:0016459 myosin complex -- -- Cluster-8309.55579 BF_2 40.13 4.83 635 642918886 XP_008191628.1 208 3.1e-14 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02384 N-6 DNA Methylase GO:0006306 DNA methylation GO:0003677//GO:0008170 DNA binding//N-methyltransferase activity -- -- -- -- Cluster-8309.55580 BF_2 340.14 6.05 2638 546683622 ERL93410.1 923 1.6e-96 hypothetical protein D910_10702 [Dendroctonus ponderosae] 676494731 XM_009068407.1 36 1.15983e-06 Lottia gigantea hypothetical protein mRNA K01057 PGLS, pgl, devB 6-phosphogluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01057 P85971 532 1.4e-52 6-phosphogluconolactonase OS=Rattus norvegicus GN=Pgls PE=1 SV=1 PF01182//PF09771 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase//Transmembrane protein 188 GO:0035307//GO:0005975 positive regulation of protein dephosphorylation//carbohydrate metabolic process -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.55581 BF_2 11.26 0.45 1342 546683622 ERL93410.1 376 2.2e-33 hypothetical protein D910_10702 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M8F7 240 5.3e-19 Nuclear envelope phosphatase-regulatory subunit 1 OS=Xenopus tropicalis GN=cnep1r1 PE=2 SV=1 PF09771 Transmembrane protein 188 GO:0035307 positive regulation of protein dephosphorylation -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.55583 BF_2 11.00 0.34 1627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55584 BF_2 6.00 0.61 699 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55585 BF_2 1.00 0.75 336 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55589 BF_2 26.13 0.31 3826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5559 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55590 BF_2 30.87 0.43 3277 642925611 XP_008194640.1 2375 8.5e-265 PREDICTED: tudor domain-containing protein 7 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6NAF9 369 1.4e-33 Tudor domain-containing protein 7A OS=Danio rerio GN=tdrd7a PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55592 BF_2 5.00 0.34 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55594 BF_2 10.24 1.04 699 91091456 XP_972862.1 396 5.5e-36 PREDICTED: aquaporin AQPcic [Tribolium castaneum]>gi|270000980|gb|EEZ97427.1| hypothetical protein TcasGA2_TC011257 [Tribolium castaneum] -- -- -- -- -- K09866 AQP4 aquaporin-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09866 Q9NHW7 348 8.3e-32 Aquaporin AQPAe.a OS=Aedes aegypti GN=AAEL003512 PE=2 SV=2 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.55595 BF_2 287.00 5.31 2549 642932739 XP_008196967.1 198 1.8e-12 PREDICTED: uncharacterized protein DDB_G0290685-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08041//PF00095 PetM family of cytochrome b6f complex subunit 7//WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576//GO:0009512 extracellular region//cytochrome b6f complex -- -- Cluster-8309.55597 BF_2 117.08 2.64 2140 642912272 XP_008200632.1 862 1.5e-89 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC103314980 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P28175 298 1.6e-25 Limulus clotting factor C OS=Tachypleus tridentatus PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.5560 BF_2 6.00 0.69 653 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55600 BF_2 5.59 0.37 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55602 BF_2 582.69 4.47 5742 642937187 XP_008198730.1 1103 4.7e-117 PREDICTED: cuticular protein analogous to peritrophins 1-J isoform X2 [Tribolium castaneum] 642937188 XM_008200510.1 61 3.21879e-20 PREDICTED: Tribolium castaneum cuticular protein analogous to peritrophins 1-J (Cpap1-j), transcript variant X2, mRNA -- -- -- -- Q685J3 144 3.1e-07 Mucin-17 OS=Homo sapiens GN=MUC17 PE=1 SV=2 PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.55609 BF_2 781.23 13.81 2653 332373676 AEE61979.1 761 9.8e-78 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q24764 129 7.8e-06 Circadian clock-controlled protein OS=Drosophila yakuba GN=anon-3B1.2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55614 BF_2 1.00 0.87 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55617 BF_2 113.32 2.37 2286 642916217 XP_008190934.1 3030 0.0e+00 PREDICTED: calpain-C [Tribolium castaneum] 195479179 XM_002100759.1 39 2.15579e-08 Drosophila yakuba GE17262 (Dyak\GE17262), partial mRNA K08578 CAPN9 calpain-9 http://www.genome.jp/dbget-bin/www_bget?ko:K08578 Q9VXH6 1662 1.2e-183 Calpain-C OS=Drosophila melanogaster GN=CalpC PE=1 SV=4 PF00648 Calpain family cysteine protease GO:0006508 proteolysis GO:0004198 calcium-dependent cysteine-type endopeptidase activity GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.55624 BF_2 15.59 0.46 1718 91092400 XP_969218.1 910 3.4e-95 PREDICTED: telomerase Cajal body protein 1 [Tribolium castaneum]>gi|270011293|gb|EFA07741.1| hypothetical protein TcasGA2_TC002221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BUR4 287 2.4e-24 Telomerase Cajal body protein 1 OS=Homo sapiens GN=WRAP53 PE=1 SV=1 PF03875//PF00400 Statherin//WD domain, G-beta repeat GO:0030500//GO:0042742 regulation of bone mineralization//defense response to bacterium GO:0046848//GO:0005515 hydroxyapatite binding//protein binding GO:0005576 extracellular region KOG2919 Guanine nucleotide-binding protein Cluster-8309.55627 BF_2 160.30 1.49 4790 642913192 XP_008201430.1 3754 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X1 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q149N8 1543 1.5e-169 E3 ubiquitin-protein ligase SHPRH OS=Homo sapiens GN=SHPRH PE=1 SV=2 PF00097//PF14634//PF00628//PF13639//PF13176//PF00176//PF00515//PF13374 Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//PHD-finger//Ring finger domain//Tetratricopeptide repeat//SNF2 family N-terminal domain//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0046872//GO:0005515//GO:0008270//GO:0005524 metal ion binding//protein binding//zinc ion binding//ATP binding -- -- KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.55629 BF_2 56.03 0.51 4921 642913192 XP_008201430.1 2686 1.1e-300 PREDICTED: E3 ubiquitin-protein ligase SHPRH isoform X1 [Tribolium castaneum] -- -- -- -- -- K15710 SHPRH E3 ubiquitin-protein ligase SHPRH http://www.genome.jp/dbget-bin/www_bget?ko:K15710 Q7TPQ3 949 1.2e-100 E3 ubiquitin-protein ligase SHPRH OS=Mus musculus GN=Shprh PE=1 SV=1 PF00097//PF12678//PF00628//PF14634//PF13639//PF13176//PF00176//PF13374//PF02891//PF00515//PF12861 Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//PHD-finger//zinc-RING finger domain//Ring finger domain//Tetratricopeptide repeat//SNF2 family N-terminal domain//Tetratricopeptide repeat//MIZ/SP-RING zinc finger//Tetratricopeptide repeat//Anaphase-promoting complex subunit 11 RING-H2 finger GO:0016567 protein ubiquitination GO:0046872//GO:0005515//GO:0004842//GO:0005524//GO:0008270 metal ion binding//protein binding//ubiquitin-protein transferase activity//ATP binding//zinc ion binding GO:0005680 anaphase-promoting complex KOG0298 DEAD box-containing helicase-like transcription factor/DNA repair protein Cluster-8309.55630 BF_2 3.00 1.32 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55631 BF_2 8.57 0.46 1060 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55632 BF_2 1.00 0.91 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55633 BF_2 96.46 2.49 1908 642927014 XP_001810799.2 867 3.6e-90 PREDICTED: peroxisomal leader peptide-processing protease [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2T9J0 255 1.4e-20 Peroxisomal leader peptide-processing protease OS=Homo sapiens GN=TYSND1 PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.55637 BF_2 148.00 2.67 2607 91080945 XP_974350.1 1122 1.3e-119 PREDICTED: RNA-binding protein 28 [Tribolium castaneum]>gi|270005371|gb|EFA01819.1| hypothetical protein TcasGA2_TC007421 [Tribolium castaneum] -- -- -- -- -- K14573 NOP4, RBM28 nucleolar protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14573 Q8CGC6 481 1.2e-46 RNA-binding protein 28 OS=Mus musculus GN=Rbm28 PE=1 SV=4 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0127 Nucleolar protein fibrillarin NOP77 (RRM superfamily) Cluster-8309.55640 BF_2 49.70 0.59 3807 642919490 XP_008191893.1 2927 0.0e+00 PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum]>gi|642919492|ref|XP_008191894.1| PREDICTED: uncharacterized protein LOC100141693 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07647//PF00536 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55643 BF_2 34.05 0.66 2455 270015916 EFA12364.1 501 1.3e-47 hypothetical protein TcasGA2_TC002070 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18583 189 8.0e-13 Protein SON OS=Homo sapiens GN=SON PE=1 SV=4 PF05493 ATP synthase subunit H GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.55645 BF_2 13.52 0.43 1607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55649 BF_2 9.56 0.35 1424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55652 BF_2 12.46 0.35 1787 642916248 XP_008190945.1 1070 9.8e-114 PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|642916250|ref|XP_008190946.1| PREDICTED: organic cation transporter protein [Tribolium castaneum]>gi|270003683|gb|EFA00131.1| hypothetical protein TcasGA2_TC002947 [Tribolium castaneum] -- -- -- -- -- K08202 SLC22A4_5, OCTN MFS transporter, OCT family, solute carrier family 22 (organic cation transporter), member 4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K08202 Q9VCA2 836 5.5e-88 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.55656 BF_2 2.00 0.53 446 -- -- -- -- -- 761231605 KM881639.1 446 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P0C377 422 1.4e-40 Cytochrome c biogenesis protein CcsA OS=Oryza sativa subsp. japonica GN=ccsA PE=3 SV=1 PF01578 Cytochrome C assembly protein GO:0017004 cytochrome complex assembly GO:0020037 heme binding -- -- -- -- Cluster-8309.55658 BF_2 43.25 1.24 1750 642923908 XP_008193923.1 350 3.0e-30 PREDICTED: polyglutamine-binding protein 1 [Tribolium castaneum]>gi|270007788|gb|EFA04236.1| hypothetical protein TcasGA2_TC014489 [Tribolium castaneum] -- -- -- -- -- K12865 PQBP1, NPW38 polyglutamine-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12865 Q2HJC9 185 1.7e-12 Polyglutamine-binding protein 1 OS=Bos taurus GN=PQBP1 PE=2 SV=1 PF02724//PF06459 CDC45-like protein//Ryanodine Receptor TM 4-6 GO:0006270//GO:0006874//GO:0006816 DNA replication initiation//cellular calcium ion homeostasis//calcium ion transport GO:0005219 ryanodine-sensitive calcium-release channel activity GO:0016021//GO:0005622 integral component of membrane//intracellular KOG3427 Polyglutamine tract-binding protein PQBP-1 Cluster-8309.55661 BF_2 190.67 7.02 1423 546673719 ERL85275.1 1541 1.9e-168 hypothetical protein D910_02696 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9CYF5 979 1.1e-104 Williams-Beuren syndrome chromosomal region 16 protein homolog OS=Mus musculus GN=Wbscr16 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1426 FOG: RCC1 domain Cluster-8309.55662 BF_2 218.03 9.27 1271 827550232 XP_012547131.1 361 1.1e-31 PREDICTED: uncharacterized protein LOC101740234 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55663 BF_2 46.00 1.69 1423 642938861 XP_970628.2 843 1.6e-87 PREDICTED: uncharacterized protein LOC659208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55664 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55666 BF_2 6.02 0.32 1067 91084661 XP_967669.1 378 1.0e-33 PREDICTED: protein phosphatase 1D [Tribolium castaneum]>gi|270008629|gb|EFA05077.1| hypothetical protein TcasGA2_TC015174 [Tribolium castaneum] -- -- -- -- -- K10147 PPM1D, WIP1 protein phosphatase 1D http://www.genome.jp/dbget-bin/www_bget?ko:K10147 O15297 215 3.3e-16 Protein phosphatase 1D OS=Homo sapiens GN=PPM1D PE=1 SV=1 PF00481//PF00570 Protein phosphatase 2C//HRDC domain GO:0006470 protein dephosphorylation GO:0003676//GO:0003824//GO:0004722//GO:0046872 nucleic acid binding//catalytic activity//protein serine/threonine phosphatase activity//metal ion binding GO:0005622//GO:0008287 intracellular//protein serine/threonine phosphatase complex KOG0698 Serine/threonine protein phosphatase Cluster-8309.55667 BF_2 207.78 10.30 1131 91077808 XP_970231.1 636 1.3e-63 PREDICTED: uncharacterized protein LOC658778 [Tribolium castaneum]>gi|270001488|gb|EEZ97935.1| hypothetical protein TcasGA2_TC000323 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08917 Transforming growth factor beta receptor 2 ectodomain GO:0007178//GO:0006468//GO:0009069//GO:0016310 transmembrane receptor protein serine/threonine kinase signaling pathway//protein phosphorylation//serine family amino acid metabolic process//phosphorylation GO:0005524//GO:0005026//GO:0046872 ATP binding//transforming growth factor beta receptor activity, type II//metal ion binding GO:0016020 membrane -- -- Cluster-8309.55671 BF_2 110.31 1.15 4297 270001539 EEZ97986.1 1949 2.8e-215 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 364 0 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1027 9.4e-110 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF16367//PF00076//PF08777 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA binding motif -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.55677 BF_2 212.00 1.86 5044 642924398 XP_008194279.1 1399 2.0e-151 PREDICTED: fibril-forming collagen alpha chain-like [Tribolium castaneum]>gi|270007894|gb|EFA04342.1| hypothetical protein TcasGA2_TC014637 [Tribolium castaneum] -- -- -- -- -- K06236 COL1AS collagen, type I/II/III/V/XI/XXIV/XXVII, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06236 Q91717 573 4.9e-57 Collagen alpha-1(II) chain OS=Xenopus laevis GN=col2a1 PE=2 SV=2 PF00714//PF01410//PF00093//PF12658 Interferon gamma//Fibrillar collagen C-terminal domain//von Willebrand factor type C domain//Telomere capping, CST complex subunit GO:0010833//GO:0007165//GO:0006955 telomere maintenance via telomere lengthening//signal transduction//immune response GO:0005133//GO:0005515//GO:0043047//GO:0005201 interferon-gamma receptor binding//protein binding//single-stranded telomeric DNA binding//extracellular matrix structural constituent GO:0005581//GO:0005576//GO:0070188//GO:0005578 collagen trimer//extracellular region//obsolete Stn1-Ten1 complex//proteinaceous extracellular matrix -- -- Cluster-8309.55680 BF_2 29.61 1.13 1381 861610178 KMQ85078.1 943 4.0e-99 dna-mediated transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12940 Recombination-activation protein 1 (RAG1) GO:0033151 V(D)J recombination GO:0043565 sequence-specific DNA binding -- -- -- -- Cluster-8309.55682 BF_2 153.68 2.14 3287 91084581 XP_973970.1 1723 3.4e-189 PREDICTED: signal peptide peptidase-like 3 isoform X1 [Tribolium castaneum]>gi|270008893|gb|EFA05341.1| hypothetical protein TcasGA2_TC015505 [Tribolium castaneum] 27820031 BT003288.1 200 9.85608e-98 Drosophila melanogaster GM06145 full insert cDNA K09598 SPPL3 signal peptide peptidase-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09598 Q9CUS9 1217 6.7e-132 Signal peptide peptidase-like 3 OS=Mus musculus GN=Sppl3 PE=1 SV=3 PF04258 Signal peptide peptidase -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG2443 Uncharacterized conserved protein Cluster-8309.55683 BF_2 2.72 3.74 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55692 BF_2 8.00 0.49 973 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55693 BF_2 2.00 0.52 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55697 BF_2 74.00 10.09 594 532759730 AGU01545.1 278 2.2e-22 antimicrobial peptide type 2 precursor IIc [Pandalopsis japonica] 820844958 XM_012485111.1 35 8.97723e-07 PREDICTED: Apis florea vegetative cell wall protein gp1-like (LOC105735137), mRNA -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.55698 BF_2 10.00 3.33 412 62088534 BAD92714.1 500 2.8e-48 anaplastic lymphoma kinase Ki-1 variant, partial [Homo sapiens] 194382373 AK296218.1 412 0 Homo sapiens cDNA FLJ60605 complete cds, highly similar to ALK tyrosine kinase receptor precursor (EC 2.7.10.1) K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 471 2.7e-46 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55699 BF_2 2.00 1.98 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11547//PF10280//PF01499//PF03985 E3 ubiquitin ligase EDD//Mediator complex protein//Herpesvirus UL25 family//Paf1 GO:0016570//GO:0006357//GO:0019072//GO:0006368 histone modification//regulation of transcription from RNA polymerase II promoter//viral genome packaging//transcription elongation from RNA polymerase II promoter GO:0001104//GO:0043130 RNA polymerase II transcription cofactor activity//ubiquitin binding GO:0042025//GO:0016593//GO:0016592 host cell nucleus//Cdc73/Paf1 complex//mediator complex -- -- Cluster-8309.55700 BF_2 72.04 2.01 1785 91083701 XP_969551.1 798 3.4e-82 PREDICTED: PITH domain-containing protein CG6153 [Tribolium castaneum]>gi|270006812|gb|EFA03260.1| hypothetical protein TcasGA2_TC013194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q29L80 614 3.0e-62 PITH domain-containing protein GA19395 OS=Drosophila pseudoobscura pseudoobscura GN=GA19395 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1730 Thioredoxin-like protein Cluster-8309.55701 BF_2 34.00 0.61 2606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55703 BF_2 21.69 0.33 3001 546682082 ERL92068.1 1318 2.9e-142 hypothetical protein D910_09390 [Dendroctonus ponderosae] -- -- -- -- -- K12487 GIT2 G protein-coupled receptor kinase interactor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12487 Q9JLQ2 789 2.6e-82 ARF GTPase-activating protein GIT2 OS=Mus musculus GN=Git2 PE=1 SV=2 PF02050//PF01166//PF03836//PF00023//PF01412//PF06005//PF13851//PF06156//PF13606 Flagellar FliJ protein//TSC-22/dip/bun family//RasGAP C-terminus//Ankyrin repeat//Putative GTPase activating protein for Arf//Protein of unknown function (DUF904)//Growth-arrest specific micro-tubule binding//Protein of unknown function (DUF972)//Ankyrin repeat GO:0043093//GO:0000917//GO:0007264//GO:0006935//GO:0048870//GO:0071973//GO:0006260//GO:0006355 FtsZ-dependent cytokinesis//barrier septum assembly//small GTPase mediated signal transduction//chemotaxis//cell motility//bacterial-type flagellum-dependent cell motility//DNA replication//regulation of transcription, DNA-templated GO:0003774//GO:0005515//GO:0003700//GO:0005096 motor activity//protein binding//transcription factor activity, sequence-specific DNA binding//GTPase activator activity GO:0016020//GO:0005667//GO:0009288//GO:0005737//GO:0031514 membrane//transcription factor complex//bacterial-type flagellum//cytoplasm//motile cilium KOG0818 GTPase-activating proteins of the GIT family Cluster-8309.55707 BF_2 15.00 3.23 481 209484239 ACI47596.1 312 2.1e-26 anaplastic lymphoma kinase [Homo sapiens] 221554531 NG_009445.1 475 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 312 8.5e-28 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55715 BF_2 210.56 4.56 2218 817053828 XP_012264100.1 1826 2.6e-201 PREDICTED: serine/threonine-protein kinase NLK [Athalia rosae] 642935874 XM_008199986.1 700 0 PREDICTED: Tribolium castaneum serine/threonine-protein kinase NLK (LOC659674), transcript variant X3, mRNA K04468 NLK nemo like kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04468 D3ZSZ3 1597 3.9e-176 Serine/threonine-protein kinase NLK OS=Rattus norvegicus GN=Nlk PE=3 SV=1 PF07714//PF06293//PF00069 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524//GO:0016773 protein kinase activity//ATP binding//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0664 Nemo-like MAPK-related serine/threonine protein kinase Cluster-8309.55716 BF_2 64.99 0.47 6063 91090340 XP_967097.1 1862 4.8e-205 PREDICTED: hexosaminidase D [Tribolium castaneum]>gi|270013820|gb|EFA10268.1| hypothetical protein TcasGA2_TC012468 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 807 4.3e-84 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728//PF02259 Glycosyl hydrolase family 20, catalytic domain//FAT domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0004553//GO:0005515 cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds//protein binding -- -- -- -- Cluster-8309.55718 BF_2 151.04 4.01 1861 546678624 ERL89206.1 602 1.9e-59 hypothetical protein D910_06580 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55721 BF_2 68.46 1.02 3103 646710389 KDR15908.1 238 5.1e-17 Protein quiver [Zootermopsis nevadensis] 462391761 APGK01018330.1 64 3.71864e-22 Dendroctonus ponderosae Seq01018340, whole genome shotgun sequence -- -- -- -- B3NSF6 232 1.0e-17 Protein quiver OS=Drosophila erecta GN=qvr PE=3 SV=1 PF17064//PF01064 Sleepless protein//Activin types I and II receptor domain GO:0007178//GO:0016310//GO:0009069//GO:0030431//GO:1903818//GO:0032222 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//sleep//positive regulation of voltage-gated potassium channel activity//regulation of synaptic transmission, cholinergic GO:0034235//GO:0004675 GPI anchor binding//transmembrane receptor protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.55723 BF_2 5.00 0.59 642 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55724 BF_2 116.06 4.11 1469 478256734 ENN76915.1 1757 1.8e-193 hypothetical protein YQE_06562, partial [Dendroctonus ponderosae]>gi|546672598|gb|ERL84399.1| hypothetical protein D910_01832 [Dendroctonus ponderosae] 807037650 XM_004533743.2 52 8.14928e-16 PREDICTED: Ceratitis capitata tyrosine--tRNA ligase, mitochondrial (LOC101458353), mRNA K01866 YARS, tyrS tyrosyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01866 Q9W107 1386 7.5e-152 Tyrosine--tRNA ligase, mitochondrial OS=Drosophila melanogaster GN=Aats-tyr-m PE=2 SV=1 PF01479//PF04377//PF00579 S4 domain//Arginine-tRNA-protein transferase, C terminus//tRNA synthetases class I (W and Y) GO:0006418//GO:0016598 tRNA aminoacylation for protein translation//protein arginylation GO:0000166//GO:0005524//GO:0003723//GO:0004057//GO:0004812 nucleotide binding//ATP binding//RNA binding//arginyltransferase activity//aminoacyl-tRNA ligase activity -- -- KOG2623 Tyrosyl-tRNA synthetase Cluster-8309.55727 BF_2 114.67 1.78 2984 642916185 XP_008190921.1 1780 7.7e-196 PREDICTED: guanine nucleotide-binding protein-like 1 isoform X1 [Tribolium castaneum]>gi|642916187|ref|XP_008190922.1| PREDICTED: guanine nucleotide-binding protein-like 1 isoform X1 [Tribolium castaneum]>gi|270004156|gb|EFA00604.1| hypothetical protein TcasGA2_TC003476 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P36916 1157 5.5e-125 Guanine nucleotide-binding protein-like 1 OS=Mus musculus GN=Gnl1 PE=2 SV=4 PF02421//PF04548//PF06858//PF01926//PF03193//PF08477 Ferrous iron transport protein B//AIG1 family//Nucleolar GTP-binding protein 1 (NOG1)//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0003924//GO:0015093//GO:0005525 GTPase activity//ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane KOG1424 Predicted GTP-binding protein MMR1 Cluster-8309.55728 BF_2 61.77 0.97 2943 642921918 XP_008192944.1 2013 7.3e-223 PREDICTED: zinc finger MYND domain-containing protein 11 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15326 593 1.4e-59 Zinc finger MYND domain-containing protein 11 OS=Homo sapiens GN=ZMYND11 PE=1 SV=2 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.55735 BF_2 172.88 3.43 2394 642927459 XP_968905.2 1040 4.0e-110 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q3SZJ4 752 4.0e-78 Prostaglandin reductase 1 OS=Bos taurus GN=PTGR1 PE=2 SV=1 PF00106//PF01118//PF01370//PF00107//PF02826 short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family//Zinc-binding dehydrogenase//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0008152 oxidation-reduction process//metabolic process GO:0051287//GO:0016620//GO:0016491//GO:0050662//GO:0003824 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity//coenzyme binding//catalytic activity -- -- -- -- Cluster-8309.55736 BF_2 59.00 2.19 1416 821021704 XP_012351898.1 379 1.0e-33 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 117-like [Nomascus leucogenys] -- -- -- -- -- K09215 OSR, ODD odd-skipped http://www.genome.jp/dbget-bin/www_bget?ko:K09215 Q6ZR52 372 2.8e-34 Zinc finger protein 493 OS=Homo sapiens GN=ZNF493 PE=2 SV=3 PF10588//PF07975//PF13465//PF00096//PF01428//PF02892//PF13912 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region//TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//AN1-like Zinc finger//BED zinc finger//C2H2-type zinc finger GO:0055114//GO:0006281 oxidation-reduction process//DNA repair GO:0046872//GO:0016491//GO:0008270//GO:0003677 metal ion binding//oxidoreductase activity//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.55737 BF_2 27.11 0.85 1616 270016102 EFA12550.1 394 2.2e-35 hypothetical protein TcasGA2_TC001958 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55738 BF_2 39.95 0.53 3419 478255117 ENN75347.1 816 5.3e-84 hypothetical protein YQE_08123, partial [Dendroctonus ponderosae] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q9UPI3 440 8.7e-42 Feline leukemia virus subgroup C receptor-related protein 2 OS=Homo sapiens GN=FLVCR2 PE=1 SV=1 PF07690//PF03137//PF10640 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//mRNA capping enzyme N-terminal, ATPase and guanylyltransferase GO:0055085//GO:0006810//GO:0006370 transmembrane transport//transport//7-methylguanosine mRNA capping GO:0005215//GO:0004484//GO:0004651 transporter activity//mRNA guanylyltransferase activity//polynucleotide 5'-phosphatase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2563 Permease of the major facilitator superfamily Cluster-8309.55740 BF_2 67.92 2.08 1656 328705425 XP_003242798.1 250 1.1e-18 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF00096//PF13465//PF00231 BED zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//ATP synthase GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003677//GO:0046933//GO:0046872//GO:0046961 DNA binding//proton-transporting ATP synthase activity, rotational mechanism//metal ion binding//proton-transporting ATPase activity, rotational mechanism GO:0045261//GO:0045259 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex -- -- Cluster-8309.55741 BF_2 9.55 0.43 1219 642920583 XP_008192473.1 225 6.4e-16 PREDICTED: uncharacterized protein LOC103312776 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF00231//PF13639//PF12678//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//ATP synthase//Ring finger domain//RING-H2 zinc finger//BED zinc finger GO:0006119//GO:0015986//GO:0015992 oxidative phosphorylation//ATP synthesis coupled proton transport//proton transport GO:0003677//GO:0005515//GO:0008270//GO:0046872//GO:0046961//GO:0046933 DNA binding//protein binding//zinc ion binding//metal ion binding//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.55743 BF_2 22.07 0.66 1687 328705425 XP_003242798.1 250 1.1e-18 PREDICTED: uncharacterized protein LOC100575481 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF13465//PF00231//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//ATP synthase//BED zinc finger GO:0006119//GO:0015992//GO:0015986 oxidative phosphorylation//proton transport//ATP synthesis coupled proton transport GO:0003677//GO:0046933//GO:0046961//GO:0046872 DNA binding//proton-transporting ATP synthase activity, rotational mechanism//proton-transporting ATPase activity, rotational mechanism//metal ion binding GO:0045261//GO:0045259 proton-transporting ATP synthase complex, catalytic core F(1)//proton-transporting ATP synthase complex -- -- Cluster-8309.55748 BF_2 9.00 1.45 546 873218379 CEM39573.1 169 8.9e-10 unnamed protein product [Vitrella brassicaformis CCMP3155] 1296815 X94995.1 444 0 Juglans nigra x Juglans regia mRNA for chalcone synthase (CHS1) -- -- -- -- Q9FUB7 540 3.5e-54 Chalcone synthase OS=Hypericum androsaemum PE=1 SV=1 PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal GO:0008610 lipid biosynthetic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.55749 BF_2 7.00 1.67 462 290996756 XP_002680948.1 218 1.6e-15 beta-ketoacyl synthase [Naegleria gruberi]>gi|284094570|gb|EFC48204.1| beta-ketoacyl synthase [Naegleria gruberi] 1296815 X94995.1 420 0 Juglans nigra x Juglans regia mRNA for chalcone synthase (CHS1) -- -- -- -- P48387 764 3.2e-80 Chalcone synthase 2 OS=Camellia sinensis GN=CHS2 PE=2 SV=1 PF08392//PF08545 FAE1/Type III polyketide synthase-like protein//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III GO:0006633//GO:0042967 fatty acid biosynthetic process//acyl-carrier-protein biosynthetic process GO:0003824//GO:0016747//GO:0004315 catalytic activity//transferase activity, transferring acyl groups other than amino-acyl groups//3-oxoacyl-[acyl-carrier-protein] synthase activity GO:0016020//GO:0005835 membrane//fatty acid synthase complex -- -- Cluster-8309.5575 BF_2 7.00 0.44 956 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.55750 BF_2 12.12 0.44 1438 546683622 ERL93410.1 376 2.3e-33 hypothetical protein D910_10702 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5M8F7 240 5.7e-19 Nuclear envelope phosphatase-regulatory subunit 1 OS=Xenopus tropicalis GN=cnep1r1 PE=2 SV=1 PF09771 Transmembrane protein 188 GO:0035307 positive regulation of protein dephosphorylation -- -- GO:0071595 Nem1-Spo7 phosphatase complex KOG3147 6-phosphogluconolactonase - like protein Cluster-8309.55755 BF_2 5.00 0.37 846 591373737 XP_007061563.1 869 9.4e-91 PREDICTED: elongation factor 1-alpha 1 [Chelonia mydas]>gi|465975678|gb|EMP34197.1| Elongation factor 1-alpha 1 [Chelonia mydas] 697073754 XM_009653212.1 595 0 Verticillium dahliae VdLs.17 elongation factor 1-alpha partial mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 P41745 866 8.6e-92 Elongation factor 1-alpha OS=Blastobotrys adeninivorans GN=TEF PE=3 SV=1 PF03144 Elongation factor Tu domain 2 -- -- GO:0005525 GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.55757 BF_2 1.00 0.39 394 823649307 AKI32824.1 604 2.3e-60 elongation factor 1-alpha, partial [Doratopsylla dasycnema dasycnema] 697073754 XM_009653212.1 373 0 Verticillium dahliae VdLs.17 elongation factor 1-alpha partial mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q01520 653 2.0e-67 Elongation factor 1-alpha OS=Podospora anserina GN=TEF PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.55759 BF_2 1.00 1.46 299 564344879 XP_006235797.1 366 7.0e-33 PREDICTED: elongation factor 1-alpha 2 isoform X2 [Rattus norvegicus] 768311754 CP010982.1 186 4.89255e-91 Verticillium dahliae VdLs.17 chromosome 3, complete sequence K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q09069 368 1.7e-34 Elongation factor 1-alpha OS=Sordaria macrospora GN=TEF PE=3 SV=1 PF01580//PF06431//PF00503 FtsK/SpoIIIE family//Polyomavirus large T antigen C-terminus//G-protein alpha subunit GO:0007186//GO:0006260//GO:0007165 G-protein coupled receptor signaling pathway//DNA replication//signal transduction GO:0000166//GO:0019001//GO:0004871//GO:0003924//GO:0005524//GO:0031683//GO:0003677 nucleotide binding//guanyl nucleotide binding//signal transducer activity//GTPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//DNA binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.55760 BF_2 31.00 0.31 4441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55761 BF_2 64.28 0.64 4521 91090274 XP_970683.1 4743 0.0e+00 PREDICTED: phosphoinositide 3-kinase regulatory subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- K08333 PIK3R4, VPS15 phosphoinositide-3-kinase, regulatory subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K08333 Q8VD65 1913 1.8e-212 Phosphoinositide 3-kinase regulatory subunit 4 OS=Mus musculus GN=Pik3r4 PE=1 SV=3 PF07714//PF00400//PF02985//PF00069 Protein tyrosine kinase//WD domain, G-beta repeat//HEAT repeat//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515 ATP binding//protein kinase activity//protein binding -- -- KOG1240 Protein kinase containing WD40 repeats Cluster-8309.55762 BF_2 10.00 0.81 806 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55763 BF_2 207.62 1.97 4694 478251484 ENN71947.1 709 1.9e-71 hypothetical protein YQE_11381, partial [Dendroctonus ponderosae] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q8BYF6 374 5.4e-34 Sodium-coupled monocarboxylate transporter 1 OS=Mus musculus GN=Slc5a8 PE=1 SV=1 PF00474 Sodium:solute symporter family GO:0055085//GO:0006810 transmembrane transport//transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.55765 BF_2 201.58 1.03 8474 478261817 ENN80940.1 1262 2.5e-135 hypothetical protein YQE_02645, partial [Dendroctonus ponderosae]>gi|546673708|gb|ERL85267.1| hypothetical protein D910_02688 [Dendroctonus ponderosae] -- -- -- -- -- K05610 UCHL5, UCH37 ubiquitin carboxyl-terminal hydrolase L5 http://www.genome.jp/dbget-bin/www_bget?ko:K05610 Q9XSJ0 1055 1.0e-112 Ubiquitin carboxyl-terminal hydrolase isozyme L5 OS=Bos taurus GN=UCHL5 PE=2 SV=1 PF00397//PF01404//PF00552//PF02845//PF00325//PF01088 WW domain//Ephrin receptor ligand binding domain//Integrase DNA binding domain//CUE domain//Bacterial regulatory proteins, crp family//Ubiquitin carboxyl-terminal hydrolase, family 1 GO:0016579//GO:0006511//GO:0006355//GO:0048013//GO:0006508 protein deubiquitination//ubiquitin-dependent protein catabolic process//regulation of transcription, DNA-templated//ephrin receptor signaling pathway//proteolysis GO:0005515//GO:0003677//GO:0004843//GO:0003676 protein binding//DNA binding//ubiquitin-specific protease activity//nucleic acid binding GO:0005622 intracellular KOG2778 Ubiquitin C-terminal hydrolase Cluster-8309.55768 BF_2 6.98 0.32 1191 189239328 XP_973240.2 1344 1.1e-145 PREDICTED: ribosome-releasing factor 2, mitochondrial [Tribolium castaneum] 242013425 XM_002427363.1 110 3.76275e-48 Pediculus humanus corporis elongation factor G 2, putative, mRNA K02355 fusA, GFM, EFG elongation factor G http://www.genome.jp/dbget-bin/www_bget?ko:K02355 Q9VCX4 991 3.9e-106 Ribosome-releasing factor 2, mitochondrial OS=Drosophila melanogaster GN=EF-G2 PE=2 SV=3 PF01926//PF03144//PF04548 50S ribosome-binding GTPase//Elongation factor Tu domain 2//AIG1 family -- -- GO:0005525 GTP binding -- -- KOG0465 Mitochondrial elongation factor Cluster-8309.55769 BF_2 4.00 0.50 622 91095249 XP_971558.1 164 3.9e-09 PREDICTED: 60S ribosome subunit biogenesis protein NIP7 homolog [Tribolium castaneum]>gi|270016870|gb|EFA13316.1| hypothetical protein TcasGA2_TC006900 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q503P2 144 3.3e-08 60S ribosome subunit biogenesis protein NIP7 homolog OS=Danio rerio GN=nip7 PE=2 SV=1 -- -- GO:0042255 ribosome assembly GO:0003723 RNA binding GO:0005634 nucleus KOG3492 Ribosome biogenesis protein NIP7 Cluster-8309.55778 BF_2 38.12 0.92 2017 91087247 XP_975518.1 943 5.9e-99 PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929756|ref|XP_008195961.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929758|ref|XP_008195962.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum]>gi|642929760|ref|XP_008195963.1| PREDICTED: proton-coupled folate transporter-like [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6DCX5 212 1.4e-15 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690//PF03137//PF00083 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//Sugar (and other) transporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215//GO:0022857 transporter activity//transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2816 Predicted transporter ADD1 (major facilitator superfamily) Cluster-8309.55779 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55780 BF_2 50.32 1.08 2239 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.55781 BF_2 1.00 3.98 260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF01701//PF00130 PHD-finger//Photosystem I reaction centre subunit IX / PsaJ//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556//GO:0015979 intracellular signal transduction//photosynthesis GO:0005515 protein binding GO:0009522 photosystem I -- -- Cluster-8309.55782 BF_2 21.68 0.47 2219 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02948 Amelogenin GO:0007275 multicellular organismal development -- -- GO:0005578 proteinaceous extracellular matrix -- -- Cluster-8309.55784 BF_2 132.04 2.24 2753 642911484 XP_008199443.1 1333 4.8e-144 PREDICTED: uncharacterized protein LOC662426 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q15599 151 2.3e-08 Na(+)/H(+) exchange regulatory cofactor NHE-RF2 OS=Homo sapiens GN=SLC9A3R2 PE=1 SV=2 PF13639//PF00595//PF14634//PF13180//PF03145 Ring finger domain//PDZ domain (Also known as DHR or GLGF)//zinc-RING finger domain//PDZ domain//Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.55789 BF_2 38.24 0.33 5149 328699348 XP_003240910.1 816 8.0e-84 PREDICTED: uncharacterized protein LOC100571439 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF01979 THAP domain//Amidohydrolase family -- -- GO:0003676//GO:0016787 nucleic acid binding//hydrolase activity -- -- -- -- Cluster-8309.55798 BF_2 20.00 0.43 2248 646704990 KDR12910.1 288 5.9e-23 hypothetical protein L798_13136 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8T4J9 134 1.7e-06 Pupal cuticle protein 27 OS=Manduca sexta GN=PCP27 PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.5580 BF_2 21.00 0.76 1448 524865070 XP_005089367.1 366 3.4e-32 PREDICTED: uncharacterized protein LOC101847229 isoform X1 [Aplysia californica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.55801 BF_2 25.00 0.42 2758 861625712 KMQ88624.1 1020 9.5e-108 hypothetical protein RF55_11861 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02527 rRNA small subunit methyltransferase G GO:0000154//GO:0006396//GO:0006364 rRNA modification//RNA processing//rRNA processing GO:0008649 rRNA methyltransferase activity GO:0005737 cytoplasm -- -- Cluster-8309.55804 BF_2 9.00 1.54 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55805 BF_2 71.48 0.80 4045 847140834 XP_012821161.1 437 5.6e-40 PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis]>gi|847140836|ref|XP_012821162.1| PREDICTED: oocyte zinc finger protein XlCOF6-like [Xenopus (Silurana) tropicalis] -- -- -- -- -- -- -- -- -- E9QAG8 409 4.1e-38 Zinc finger protein 431 OS=Mus musculus GN=Znf431 PE=1 SV=1 PF13912//PF17123//PF02892//PF07776//PF16622//PF13465//PF00096 C2H2-type zinc finger//RING-like zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0003677//GO:0008270//GO:0046872//GO:0005515 DNA binding//zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.55807 BF_2 14.71 0.53 1445 270015869 EFA12317.1 327 1.1e-27 hypothetical protein TcasGA2_TC004218 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01184 GPR1/FUN34/yaaH family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.55810 BF_2 165.06 4.71 1754 332374182 AEE62232.1 1026 1.2e-108 unknown [Dendroctonus ponderosae] 805779661 XM_003702443.2 140 1.17738e-64 PREDICTED: Megachile rotundata small nuclear ribonucleoprotein Sm D3 (LOC100875824), mRNA K06127 COQ5 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase http://www.genome.jp/dbget-bin/www_bget?ko:K06127 Q9VYF8 876 1.2e-92 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial OS=Drosophila melanogaster GN=Coq5 PE=2 SV=1 PF00107//PF01209//PF05148//PF01795//PF08241 Zinc-binding dehydrogenase//ubiE/COQ5 methyltransferase family//Hypothetical methyltransferase//MraW methylase family//Methyltransferase domain GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0008168 methyltransferase activity -- -- KOG1540 Ubiquinone biosynthesis methyltransferase COQ5 Cluster-8309.55812 BF_2 79.74 1.39 2695 642927091 XP_008195134.1 2880 0.0e+00 PREDICTED: rhophilin-2 isoform X3 [Tribolium castaneum]>gi|270010028|gb|EFA06476.1| hypothetical protein TcasGA2_TC009368 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6TNR1 1240 1.2e-134 Rhophilin-2 OS=Danio rerio GN=rhpn2 PE=2 SV=1 PF13180//PF02185//PF00595 PDZ domain//Hr1 repeat//PDZ domain (Also known as DHR or GLGF) GO:0007165 signal transduction GO:0005515 protein binding GO:0005622 intracellular KOG2220 Predicted signal transduction protein Cluster-8309.55814 BF_2 102.00 11.44 660 642922950 XP_008200465.1 463 8.8e-44 PREDICTED: 28S ribosomal protein S14, mitochondrial [Tribolium castaneum]>gi|270008302|gb|EFA04750.1| hypothetical protein TcasGA2_TC030556 [Tribolium castaneum] -- -- -- -- -- K02954 RP-S14, MRPS14, rpsN small subunit ribosomal protein S14 http://www.genome.jp/dbget-bin/www_bget?ko:K02954 Q6B860 353 2.1e-32 28S ribosomal protein S14, mitochondrial OS=Bos taurus GN=MRPS14 PE=1 SV=1 PF00253 Ribosomal protein S14p/S29e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1741 Mitochondrial/chloroplast ribosomal protein S14/S29 Cluster-8309.55815 BF_2 5.00 1.72 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55816 BF_2 3.00 0.59 500 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55819 BF_2 152.47 12.41 801 157112715 XP_001657613.1 423 4.6e-39 AAEL006251-PA [Aedes aegypti]>gi|122117820|sp|Q176V0.1|UFM1_AEDAE RecName: Full=Ubiquitin-fold modifier 1; Flags: Precursor [Aedes aegypti]>gi|108877961|gb|EAT42186.1| AAEL006251-PA [Aedes aegypti] -- -- -- -- -- K12162 UFM1 ubiquitin-fold modifier 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12162 Q176V0 423 1.9e-40 Ubiquitin-fold modifier 1 OS=Aedes aegypti GN=AAEL006251 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3483 Uncharacterized conserved protein Cluster-8309.55827 BF_2 200.00 14.11 880 546677164 ERL88054.1 460 2.6e-43 hypothetical protein D910_05443 [Dendroctonus ponderosae] -- -- -- -- -- K09621 KLK12 kallikrein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09621 Q00871 350 6.1e-32 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.55828 BF_2 62.87 5.22 791 270002738 EEZ99185.1 467 3.6e-44 serine protease H6 [Tribolium castaneum] 462358611 APGK01030035.1 93 6.95069e-39 Dendroctonus ponderosae Seq01030045, whole genome shotgun sequence -- -- -- -- E1BLP6 266 3.0e-22 AT-rich interactive domain-containing protein 5B OS=Bos taurus GN=ARID5B PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55836 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55839 BF_2 13.00 0.47 1456 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55842 BF_2 4.50 42.11 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55847 BF_2 9.00 2.95 414 641794635 XP_008160947.1 285 2.4e-23 PREDICTED: receptor tyrosine-protein kinase erbB-2 [Chrysemys picta bellii] 171906587 NG_007503.1 414 0 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), RefSeqGene on chromosome 17 K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 P04626 278 6.4e-24 Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens GN=ERBB2 PE=1 SV=1 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- KOG1025 Epidermal growth factor receptor EGFR and related tyrosine kinases Cluster-8309.55852 BF_2 10.00 1.14 653 270008606 EFA05054.1 600 1.1e-59 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55853 BF_2 7.62 0.65 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55854 BF_2 223.37 4.22 2500 642931178 XP_001810533.2 1913 2.4e-211 PREDICTED: general transcription factor 3C polypeptide 3 [Tribolium castaneum]>gi|270011861|gb|EFA08309.1| hypothetical protein TcasGA2_TC005945 [Tribolium castaneum] -- -- -- -- -- K15201 GTP3C3, TFC4 general transcription factor 3C polypeptide 3 (transcription factor C subunit 4) http://www.genome.jp/dbget-bin/www_bget?ko:K15201 Q9Y5Q9 739 1.4e-76 General transcription factor 3C polypeptide 3 OS=Homo sapiens GN=GTF3C3 PE=1 SV=1 PF13414//PF16045//PF13176//PF08631//PF00515//PF13181 TPR repeat//LisH//Tetratricopeptide repeat//Meiosis protein SPO22/ZIP4 like//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0051321 meiotic cell cycle GO:0005515 protein binding -- -- KOG2076 RNA polymerase III transcription factor TFIIIC Cluster-8309.55855 BF_2 31.61 1.25 1341 270001519 EEZ97966.1 789 2.8e-81 hypothetical protein TcasGA2_TC000358 [Tribolium castaneum] -- -- -- -- -- K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 223 5.0e-17 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF16331//PF01608//PF04111//PF16716//PF04871//PF06810//PF01920//PF10473//PF09177//PF04728//PF11365//PF08702//PF02183 TolA binding protein trimerisation//I/LWEQ domain//Autophagy protein Apg6//Bone marrow stromal antigen 2//Uso1 / p115 like vesicle tethering protein, C terminal region//Phage minor structural protein GP20//Prefoldin subunit//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Syntaxin 6, N-terminal//Lipoprotein leucine-zipper//Protein of unknown function (DUF3166)//Fibrinogen alpha/beta chain family//Homeobox associated leucine zipper GO:0030168//GO:0051607//GO:0048193//GO:0006457//GO:0015031//GO:0006355//GO:0006914//GO:0051258//GO:0070206//GO:0006886//GO:0010506//GO:0007165 platelet activation//defense response to virus//Golgi vesicle transport//protein folding//protein transport//regulation of transcription, DNA-templated//autophagy//protein polymerization//protein trimerization//intracellular protein transport//regulation of autophagy//signal transduction GO:0030674//GO:0042803//GO:0003700//GO:0051082//GO:0043565//GO:0008565//GO:0005102//GO:0005198//GO:0003779//GO:0045502//GO:0008134 protein binding, bridging//protein homodimerization activity//transcription factor activity, sequence-specific DNA binding//unfolded protein binding//sequence-specific DNA binding//protein transporter activity//receptor binding//structural molecule activity//actin binding//dynein binding//transcription factor binding GO:0016020//GO:0005667//GO:0030286//GO:0019867//GO:0005615//GO:0016272//GO:0005737//GO:0005577 membrane//transcription factor complex//dynein complex//outer membrane//extracellular space//prefoldin complex//cytoplasm//fibrinogen complex -- -- Cluster-8309.55856 BF_2 55.11 0.47 5202 270009045 EFA05493.1 2683 2.6e-300 hypothetical protein TcasGA2_TC015678 [Tribolium castaneum] 194763458 XM_001963814.1 371 0 Drosophila ananassae GF21038 (Dana\GF21038), mRNA -- -- -- -- Q9JJZ8 950 9.7e-101 Cyclic nucleotide-gated cation channel alpha-3 OS=Mus musculus GN=Cnga3 PE=1 SV=2 PF00520//PF03938 Ion transport protein//Outer membrane protein (OmpH-like) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0051082//GO:0005216 unfolded protein binding//ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.55859 BF_2 47.83 1.15 2022 675379531 KFM72433.1 325 2.7e-27 Zinc finger protein 99, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UK10 284 6.3e-24 Zinc finger protein 225 OS=Homo sapiens GN=ZNF225 PE=2 SV=2 PF07975//PF00096//PF13465//PF07776//PF13912//PF04810 TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Sec23/Sec24 zinc finger GO:0006281//GO:0006886//GO:0006888 DNA repair//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.5586 BF_2 26.00 0.32 3664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55865 BF_2 76.34 4.76 958 91083363 XP_975142.1 498 1.1e-47 PREDICTED: diacylglycerol O-acyltransferase 1 [Tribolium castaneum]>gi|270007773|gb|EFA04221.1| hypothetical protein TcasGA2_TC014471 [Tribolium castaneum] -- -- -- -- -- K11155 DGAT1 diacylglycerol O-acyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11155 Q8MK44 147 2.3e-08 Diacylglycerol O-acyltransferase 1 OS=Bos taurus GN=DGAT1 PE=2 SV=2 -- -- GO:0042967 acyl-carrier-protein biosynthetic process GO:0008374 O-acyltransferase activity GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane -- -- Cluster-8309.55867 BF_2 13.00 2.13 542 -- -- -- -- -- 584458492 NG_033929.1 542 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55869 BF_2 10.00 2.09 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55870 BF_2 4.00 0.52 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55871 BF_2 11.44 1.36 639 91084789 XP_972673.1 485 2.4e-46 PREDICTED: 6-pyruvoyl tetrahydrobiopterin synthase [Tribolium castaneum]>gi|270008955|gb|EFA05403.1| hypothetical protein TcasGA2_TC015575 [Tribolium castaneum] -- -- -- -- -- K01737 queD, ptpS, PTS 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01737 P48611 360 3.1e-33 6-pyruvoyl tetrahydrobiopterin synthase OS=Drosophila melanogaster GN=pr PE=1 SV=1 -- -- GO:0046656//GO:0006729 folic acid biosynthetic process//tetrahydrobiopterin biosynthetic process GO:0046872//GO:0003874 metal ion binding//6-pyruvoyltetrahydropterin synthase activity -- -- KOG4105 6-pyruvoyl tetrahydrobiopterin synthase Cluster-8309.55873 BF_2 115.72 2.62 2137 189235172 XP_001811552.1 2109 3.9e-234 PREDICTED: discoidin domain-containing receptor 2 [Tribolium castaneum]>gi|270003118|gb|EEZ99565.1| hypothetical protein TcasGA2_TC001549 [Tribolium castaneum] 749791080 XM_011150425.1 87 4.17648e-35 PREDICTED: Harpegnathos saltator discoidin domain-containing receptor 2-like (LOC105188791), transcript variant X2, mRNA K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 687 1.2e-70 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 PF02480//PF00228 Alphaherpesvirus glycoprotein E//Bowman-Birk serine protease inhibitor family GO:0007155 cell adhesion GO:0004867 serine-type endopeptidase inhibitor activity GO:0005576//GO:0016020 extracellular region//membrane KOG1094 Discoidin domain receptor DDR1 Cluster-8309.55875 BF_2 257.05 1.57 7149 189241799 XP_970228.2 3101 0.0e+00 PREDICTED: inverted formin-2 [Tribolium castaneum]>gi|270001160|gb|EEZ97607.1| hypothetical protein TcasGA2_TC011477 [Tribolium castaneum] 642925592 XM_008196391.1 437 0 PREDICTED: Tribolium castaneum uncharacterized LOC658801 (LOC658801), mRNA -- -- -- -- Q9C0D6 714 3.1e-73 FH2 domain-containing protein 1 OS=Homo sapiens GN=FHDC1 PE=1 SV=2 PF06371//PF06367 Diaphanous GTPase-binding Domain//Diaphanous FH3 Domain GO:0016043//GO:0030036 cellular component organization//actin cytoskeleton organization GO:0003779//GO:0017048 actin binding//Rho GTPase binding -- -- KOG1922 Rho GTPase effector BNI1 and related formins Cluster-8309.55877 BF_2 115.15 3.37 1718 546673009 ERL84695.1 199 9.4e-13 hypothetical protein D910_02121 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- C3XVM1 144 9.2e-08 Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial OS=Branchiostoma floridae GN=BRAFLDRAFT_270748 PE=3 SV=1 PF02686 Glu-tRNAGln amidotransferase C subunit GO:0006450 regulation of translational fidelity -- -- -- -- -- -- Cluster-8309.55882 BF_2 29.00 0.48 2832 270015858 EFA12306.1 625 6.2e-62 hypothetical protein TcasGA2_TC016101 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55885 BF_2 98.44 2.04 2307 91093732 XP_968487.1 1174 1.1e-125 PREDICTED: nuclear hormone receptor HR96 [Tribolium castaneum]>gi|270014223|gb|EFA10671.1| hormone receptor in 96-like protein [Tribolium castaneum] -- -- -- -- -- K14035 NR1IN nuclear receptor subfamily 1 group I http://www.genome.jp/dbget-bin/www_bget?ko:K14035 Q24143 751 5.1e-78 Nuclear hormone receptor HR96 OS=Drosophila melanogaster GN=Hr96 PE=1 SV=1 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401//GO:0007165 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway//signal transduction GO:0008270//GO:0043565//GO:0003700//GO:0046872//GO:0003707 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding//steroid hormone receptor activity GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3575 FOG: Hormone receptors Cluster-8309.55886 BF_2 3.92 0.34 763 556755034 XP_005972877.1 200 3.2e-13 PREDICTED: uncharacterized protein LOC102334906 [Pantholops hodgsonii] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG3700 Predicted acyltransferase Cluster-8309.55896 BF_2 148.13 0.91 7094 270006609 EFA03057.1 1367 1.4e-147 hypothetical protein TcasGA2_TC010913 [Tribolium castaneum] 688610729 XM_009296665.1 57 6.65937e-18 PREDICTED: Danio rerio protein kinase C binding protein 1, like (prkcbp1l), transcript variant X8, mRNA -- -- -- -- Q9ULU4 819 2.0e-85 Protein kinase C-binding protein 1 OS=Homo sapiens GN=ZMYND8 PE=1 SV=2 PF00439//PF00628//PF03832 Bromodomain//PHD-finger//WSK motif GO:0007165//GO:0006605 signal transduction//protein targeting GO:0005515 protein binding -- -- KOG3612 PHD Zn-finger protein Cluster-8309.55899 BF_2 107.84 2.12 2413 91088973 XP_966480.1 2893 0.0e+00 PREDICTED: G protein-coupled receptor kinase 1 [Tribolium castaneum]>gi|270011553|gb|EFA08001.1| hypothetical protein TcasGA2_TC005590 [Tribolium castaneum] 158300636 XM_320502.4 498 0 Anopheles gambiae str. PEST AGAP012026-PA (AgaP_AGAP012026) mRNA, partial cds K00910 ADRBK, GRK beta-adrenergic-receptor kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00910 P32865 2605 5.5e-293 G protein-coupled receptor kinase 1 OS=Drosophila melanogaster GN=Gprk1 PE=2 SV=2 PF00069//PF06293//PF07714 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase GO:0006468//GO:0009069//GO:0016310//GO:0038032 protein phosphorylation//serine family amino acid metabolic process//phosphorylation//termination of G-protein coupled receptor signaling pathway GO:0005524//GO:0004703//GO:0004672//GO:0016773 ATP binding//G-protein coupled receptor kinase activity//protein kinase activity//phosphotransferase activity, alcohol group as acceptor GO:0016020 membrane KOG0986 G protein-coupled receptor kinase Cluster-8309.559 BF_2 1.00 0.90 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55903 BF_2 45.00 3.88 772 -- -- -- -- -- 225697849 FJ827761.1 756 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- -- -- -- -- PF05746 DALR anticodon binding domain GO:0006420//GO:0006525//GO:0006560 arginyl-tRNA aminoacylation//arginine metabolic process//proline metabolic process GO:0005524//GO:0004814 ATP binding//arginine-tRNA ligase activity -- -- -- -- Cluster-8309.55904 BF_2 7.00 0.40 1014 642911051 XP_008200619.1 151 2.0e-07 PREDICTED: HEAT repeat-containing protein 5B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55905 BF_2 4.00 1.45 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55907 BF_2 4.74 0.46 715 642932834 XP_008197005.1 377 8.9e-34 PREDICTED: uncharacterized protein LOC663161 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55910 BF_2 20.00 20.93 316 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55912 BF_2 24.24 0.49 2365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55915 BF_2 206.24 4.47 2216 91080649 XP_974556.1 3097 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase TRIM9 [Tribolium castaneum]>gi|270005500|gb|EFA01948.1| hypothetical protein TcasGA2_TC007563 [Tribolium castaneum] 645006803 XM_008206707.1 83 7.25138e-33 PREDICTED: Nasonia vitripennis E3 ubiquitin-protein ligase TRIM9 (LOC100121486), transcript variant X3, mRNA K10649 TRIM9_67 tripartite motif-containing protein 9/67 http://www.genome.jp/dbget-bin/www_bget?ko:K10649 Q29RQ5 1656 5.6e-183 E3 ubiquitin-protein ligase TRIM9 OS=Bos taurus GN=TRIM9 PE=2 SV=1 PF00097//PF04048//PF01442//PF00643//PF00622//PF05823//PF00041//PF02601 Zinc finger, C3HC4 type (RING finger)//Sec8 exocyst complex component specific domain//Apolipoprotein A1/A4/E domain//B-box zinc finger//SPRY domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1)//Fibronectin type III domain//Exonuclease VII, large subunit GO:0042157//GO:0006869//GO:0006904//GO:0015031//GO:0006308 lipoprotein metabolic process//lipid transport//vesicle docking involved in exocytosis//protein transport//DNA catabolic process GO:0008289//GO:0005515//GO:0008855//GO:0008270//GO:0046872 lipid binding//protein binding//exodeoxyribonuclease VII activity//zinc ion binding//metal ion binding GO:0000145//GO:0005622//GO:0009318//GO:0005576 exocyst//intracellular//exodeoxyribonuclease VII complex//extracellular region KOG4367 Predicted Zn-finger protein Cluster-8309.55916 BF_2 52.76 1.15 2213 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55918 BF_2 1002.71 12.45 3657 91091628 XP_970031.1 1242 2.3e-133 PREDICTED: dihydroorotate dehydrogenase (quinone), mitochondrial [Tribolium castaneum] 780117224 XM_775688.3 40 9.63886e-09 PREDICTED: Strongylocentrotus purpuratus cathepsin L1 (LOC575275), mRNA K00254 DHODH, pyrD dihydroorotate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00254 P32748 1000 1.1e-106 Dihydroorotate dehydrogenase (quinone), mitochondrial OS=Drosophila melanogaster GN=Dhod PE=2 SV=2 PF03060//PF04139//PF15163//PF02144//PF03051//PF01180//PF00112 Nitronate monooxygenase//Rad9//Meiosis-expressed//Repair protein Rad1/Rec1/Rad17//Peptidase C1-like family//Dihydroorotate dehydrogenase//Papain family cysteine protease GO:0006281//GO:0006807//GO:0055114//GO:0000077//GO:0006508 DNA repair//nitrogen compound metabolic process//oxidation-reduction process//DNA damage checkpoint//proteolysis GO:0018580//GO:0004197//GO:0016627//GO:0008234 nitronate monooxygenase activity//cysteine-type endopeptidase activity//oxidoreductase activity, acting on the CH-CH group of donors//cysteine-type peptidase activity GO:0005634//GO:0030896//GO:0005737 nucleus//checkpoint clamp complex//cytoplasm KOG1436 Dihydroorotate dehydrogenase Cluster-8309.55921 BF_2 44.51 9.26 488 478262655 ENN81212.1 200 2.0e-13 hypothetical protein YQE_02381, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55923 BF_2 148.91 2.94 2407 642918676 XP_008191534.1 1111 2.3e-118 PREDICTED: SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 isoform X3 [Tribolium castaneum] 657589840 XM_008301108.1 80 3.66919e-31 PREDICTED: Stegastes partitus SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 (smarce1), transcript variant X4, mRNA K11651 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E, member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11651 O54941 653 1.2e-66 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 OS=Mus musculus GN=Smarce1 PE=1 SV=1 PF01496//PF05478 V-type ATPase 116kDa subunit family//Prominin GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016021//GO:0033179 integral component of membrane//proton-transporting V-type ATPase, V0 domain KOG4715 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin Cluster-8309.55927 BF_2 7.65 0.33 1250 642924697 XP_008194403.1 478 3.0e-45 PREDICTED: prolactin regulatory element-binding protein isoform X2 [Tribolium castaneum] -- -- -- -- -- K14003 PREB, SEC12 prolactin regulatory element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14003 Q9HCU5 147 3.0e-08 Prolactin regulatory element-binding protein OS=Homo sapiens GN=PREB PE=1 SV=2 -- -- -- -- -- -- -- -- KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p Cluster-8309.55928 BF_2 44.92 1.13 1945 91083955 XP_975011.1 1487 4.7e-162 PREDICTED: prolactin regulatory element-binding protein isoform X1 [Tribolium castaneum]>gi|270007977|gb|EFA04425.1| hypothetical protein TcasGA2_TC014725 [Tribolium castaneum] -- -- -- -- -- K14003 PREB, SEC12 prolactin regulatory element-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K14003 Q9HCU5 441 3.8e-42 Prolactin regulatory element-binding protein OS=Homo sapiens GN=PREB PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0771 Prolactin regulatory element-binding protein/Protein transport protein SEC12p Cluster-8309.55930 BF_2 93.50 2.31 1983 91079722 XP_969695.1 2570 1.3e-287 PREDICTED: xenotropic and polytropic retrovirus receptor 1 [Tribolium castaneum]>gi|270003331|gb|EEZ99778.1| hypothetical protein TcasGA2_TC002557 [Tribolium castaneum] 827561892 XM_004932993.2 53 3.07796e-16 PREDICTED: Bombyx mori xenotropic and polytropic retrovirus receptor 1 (LOC101739894), mRNA -- -- -- -- Q9Z0U0 1658 2.9e-183 Xenotropic and polytropic retrovirus receptor 1 OS=Mus musculus GN=Xpr1 PE=1 SV=1 PF03124 EXS family -- -- -- -- GO:0016021 integral component of membrane KOG1162 Predicted small molecule transporter Cluster-8309.55931 BF_2 25.60 0.42 2810 642935255 XP_008197934.1 1686 5.7e-185 PREDICTED: coiled-coil domain-containing protein 142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07393//PF04437 Exocyst complex component Sec10//RINT-1 / TIP-1 family GO:0006887//GO:0048278//GO:0048193 exocytosis//vesicle docking//Golgi vesicle transport -- -- GO:0005737//GO:0005783 cytoplasm//endoplasmic reticulum -- -- Cluster-8309.55932 BF_2 42.48 0.86 2344 642933977 XP_008197588.1 1324 4.5e-143 PREDICTED: UDP-glucuronosyltransferase 2C1-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O02663 615 3.0e-62 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.55933 BF_2 28.00 2.30 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55934 BF_2 44.15 1.11 1950 270013655 EFA10103.1 802 1.3e-82 hypothetical protein TcasGA2_TC012282 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q8BWQ1 308 1.0e-26 UDP-glucuronosyltransferase 2A3 OS=Mus musculus GN=Ugt2a3 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.55937 BF_2 30.30 0.33 4137 642935255 XP_008197934.1 1662 5.1e-182 PREDICTED: coiled-coil domain-containing protein 142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06338//PF04437 ComK protein//RINT-1 / TIP-1 family GO:0048193//GO:0030420 Golgi vesicle transport//establishment of competence for transformation -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-8309.55938 BF_2 39.00 1.02 1884 642933975 XP_972090.2 1364 8.4e-148 PREDICTED: UDP-glucuronosyltransferase 2B10-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P36537 633 2.0e-64 UDP-glucuronosyltransferase 2B10 OS=Homo sapiens GN=UGT2B10 PE=1 SV=1 PF04101//PF00201//PF06506//PF03839 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase//Propionate catabolism activator//Translocation protein Sec62 GO:0015031//GO:0008152//GO:0000160 protein transport//metabolic process//phosphorelay signal transduction system GO:0008565//GO:0000156//GO:0016758//GO:0005524//GO:0003677 protein transporter activity//phosphorelay response regulator activity//transferase activity, transferring hexosyl groups//ATP binding//DNA binding GO:0016021 integral component of membrane -- -- Cluster-8309.55940 BF_2 86.29 2.66 1644 642933975 XP_972090.2 1181 1.2e-126 PREDICTED: UDP-glucuronosyltransferase 2B10-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWQ1 523 9.9e-52 UDP-glucuronosyltransferase 2A3 OS=Mus musculus GN=Ugt2a3 PE=1 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.55941 BF_2 109.52 2.51 2109 642933977 XP_008197588.1 1322 6.9e-143 PREDICTED: UDP-glucuronosyltransferase 2C1-like [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 O02663 625 1.9e-63 UDP-glucuronosyltransferase 2B9 OS=Macaca fascicularis GN=UGT2B9 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.55944 BF_2 102.39 0.78 5779 642920242 XP_008192264.1 5524 0.0e+00 PREDICTED: uncharacterized protein CG43867 isoform X2 [Tribolium castaneum] 194768448 XM_001966288.1 67 1.49664e-23 Drosophila ananassae GF22056 (Dana\GF22056), mRNA -- -- -- -- Q9W5D0 2394 3.9e-268 Uncharacterized protein CG43867 OS=Drosophila melanogaster GN=CG43867 PE=1 SV=4 PF05864//PF00784 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//MyTH4 domain GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005856//GO:0005730 cytoskeleton//nucleolus KOG0248 Cytoplasmic protein Max-1, contains PH, MyTH4 and FERM domains Cluster-8309.55948 BF_2 191.35 1.48 5689 390362249 XP_001190749.2 822 1.8e-84 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 683 9.6e-70 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55949 BF_2 122.26 0.89 6004 390362249 XP_001190749.2 822 1.9e-84 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q4UMH6 683 1.0e-69 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.55953 BF_2 20.56 0.46 2175 91075962 XP_969092.1 1390 9.3e-151 PREDICTED: ATP-dependent DNA helicase Q1 [Tribolium castaneum]>gi|270014620|gb|EFA11068.1| hypothetical protein TcasGA2_TC004664 [Tribolium castaneum] -- -- -- -- -- K10899 RECQL ATP-dependent DNA helicase Q1 http://www.genome.jp/dbget-bin/www_bget?ko:K10899 P46063 1160 1.8e-125 ATP-dependent DNA helicase Q1 OS=Homo sapiens GN=RECQL PE=1 SV=3 PF00270//PF09177//PF04851//PF07517 DEAD/DEAH box helicase//Syntaxin 6, N-terminal//Type III restriction enzyme, res subunit//SecA DEAD-like domain GO:0017038//GO:0048193 protein import//Golgi vesicle transport GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding GO:0016020 membrane KOG0351 ATP-dependent DNA helicase Cluster-8309.55954 BF_2 51.62 0.67 3487 642928840 XP_008195584.1 1808 5.1e-199 PREDICTED: dystrophin, isoform E-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7YU29 530 3.3e-52 Dystrophin, isoform E OS=Drosophila melanogaster GN=Dys PE=1 SV=1 PF00569//PF00397 Zinc finger, ZZ type//WW domain -- -- GO:0005515//GO:0008270 protein binding//zinc ion binding -- -- -- -- Cluster-8309.55956 BF_2 192.60 4.65 2019 332376975 AEE63627.1 1501 1.2e-163 unknown [Dendroctonus ponderosae]>gi|478253526|gb|ENN73844.1| hypothetical protein YQE_09536, partial [Dendroctonus ponderosae]>gi|546685398|gb|ERL94911.1| hypothetical protein D910_12183 [Dendroctonus ponderosae] 557318375 XM_006032317.1 141 3.7782e-65 PREDICTED: Alligator sinensis general transcription factor IIB (GTF2B), mRNA K03124 TFIIB, GTF2B, SUA7, tfb transcription initiation factor TFIIB http://www.genome.jp/dbget-bin/www_bget?ko:K03124 P29052 1367 1.7e-149 Transcription initiation factor IIB OS=Drosophila melanogaster GN=TfIIB PE=2 SV=1 PF04545//PF02984//PF00382//PF01857 Sigma-70, region 4//Cyclin, C-terminal domain//Transcription factor TFIIB repeat//Retinoblastoma-associated protein B domain GO:0051726//GO:0006352//GO:0006355 regulation of cell cycle//DNA-templated transcription, initiation//regulation of transcription, DNA-templated GO:0003677//GO:0017025//GO:0003700//GO:0016987 DNA binding//TBP-class protein binding//transcription factor activity, sequence-specific DNA binding//sigma factor activity GO:0005667//GO:0005634 transcription factor complex//nucleus KOG1597 Transcription initiation factor TFIIB Cluster-8309.55958 BF_2 47.60 0.82 2725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55959 BF_2 39.00 1.64 1284 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55960 BF_2 34.00 1.80 1079 -- -- -- -- -- 336042955 JF276429.1 1076 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55963 BF_2 195.27 14.64 845 675389799 KFM82696.1 885 1.3e-92 Myosin light chain kinase, smooth muscle, partial [Stegodyphus mimosarum] -- -- -- -- -- K00907 MYLK myosin-light-chain kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00907 Q15746 729 6.6e-76 Myosin light chain kinase, smooth muscle OS=Homo sapiens GN=MYLK PE=1 SV=4 PF06293//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein kinase activity GO:0016020 membrane -- -- Cluster-8309.55965 BF_2 278.64 5.20 2530 91093353 XP_969001.1 1170 3.5e-125 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] -- -- -- -- -- K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 A0JPQ8 579 4.9e-58 Alkylglycerol monooxygenase OS=Rattus norvegicus GN=Agmo PE=2 SV=1 PF16954//PF05699 Haem-transporter, endosomal/lysosomal, haem-responsive gene//hAT family C-terminal dimerisation region GO:0055114//GO:0006633//GO:0015886 oxidation-reduction process//fatty acid biosynthetic process//heme transport GO:0005506//GO:0015232//GO:0046983//GO:0016491 iron ion binding//heme transporter activity//protein dimerization activity//oxidoreductase activity GO:0016021 integral component of membrane -- -- Cluster-8309.55967 BF_2 186.28 5.78 1636 91093353 XP_969001.1 676 4.4e-68 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] 642938346 XM_963908.3 55 1.95556e-17 PREDICTED: Tribolium castaneum alkylglycerol monooxygenase (LOC657448), mRNA K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 Q5M8F9 395 6.9e-37 Alkylglycerol monooxygenase OS=Xenopus tropicalis GN=agmo PE=2 SV=1 PF04116 Fatty acid hydroxylase superfamily GO:0055114//GO:0044710//GO:0006633 oxidation-reduction process//single-organism metabolic process//fatty acid biosynthetic process GO:0005506//GO:0016491 iron ion binding//oxidoreductase activity GO:0016020 membrane -- -- Cluster-8309.55970 BF_2 22.95 0.43 2515 91093353 XP_969001.1 1170 3.5e-125 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] -- -- -- -- -- K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 A0JPQ8 579 4.9e-58 Alkylglycerol monooxygenase OS=Rattus norvegicus GN=Agmo PE=2 SV=1 PF16954//PF05699 Haem-transporter, endosomal/lysosomal, haem-responsive gene//hAT family C-terminal dimerisation region GO:0055114//GO:0015886//GO:0006633 oxidation-reduction process//heme transport//fatty acid biosynthetic process GO:0005506//GO:0016491//GO:0046983//GO:0015232 iron ion binding//oxidoreductase activity//protein dimerization activity//heme transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.55971 BF_2 92.15 2.09 2129 91093353 XP_969001.1 681 1.5e-68 PREDICTED: alkylglycerol monooxygenase [Tribolium castaneum]>gi|270015303|gb|EFA11751.1| hypothetical protein TcasGA2_TC004241 [Tribolium castaneum] 642938346 XM_963908.3 55 2.55774e-17 PREDICTED: Tribolium castaneum alkylglycerol monooxygenase (LOC657448), mRNA K15537 AGMO alkylglycerol monooxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K15537 Q5M8F9 399 3.1e-37 Alkylglycerol monooxygenase OS=Xenopus tropicalis GN=agmo PE=2 SV=1 PF04116//PF00752 Fatty acid hydroxylase superfamily//XPG N-terminal domain GO:0006281//GO:0006633//GO:0044710//GO:0055114 DNA repair//fatty acid biosynthetic process//single-organism metabolic process//oxidation-reduction process GO:0016491//GO:0004518//GO:0005506 oxidoreductase activity//nuclease activity//iron ion binding GO:0016020 membrane -- -- Cluster-8309.55973 BF_2 4.73 0.40 776 91076104 XP_968648.1 382 2.5e-34 PREDICTED: 1,4-alpha-glucan-branching enzyme [Tribolium castaneum]>gi|270014582|gb|EFA11030.1| hypothetical protein TcasGA2_TC004619 [Tribolium castaneum] -- -- -- -- -- K00700 glgB 1,4-alpha-glucan branching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K00700 Q9D6Y9 221 4.9e-17 1,4-alpha-glucan-branching enzyme OS=Mus musculus GN=Gbe1 PE=2 SV=1 PF02922 Carbohydrate-binding module 48 (Isoamylase N-terminal domain) GO:0005975//GO:0005978//GO:0005985//GO:0005982 carbohydrate metabolic process//glycogen biosynthetic process//sucrose metabolic process//starch metabolic process GO:0003844//GO:0043169//GO:0004553 1,4-alpha-glucan branching enzyme activity//cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG0470 1,4-alpha-glucan branching enzyme/starch branching enzyme II Cluster-8309.55974 BF_2 525.58 29.17 1041 270011245 EFA07693.1 507 1.1e-48 hypothetical protein TcasGA2_TC030782, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5X3B2 187 5.7e-13 Adipocyte plasma membrane-associated protein OS=Salmo salar GN=apmap PE=2 SV=1 PF01436 NHL repeat -- -- GO:0005515 protein binding -- -- KOG1520 Predicted alkaloid synthase/Surface mucin Hemomucin Cluster-8309.55980 BF_2 2.28 0.96 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55981 BF_2 139.00 6.13 1235 332374090 AEE62186.1 1080 4.7e-115 unknown [Dendroctonus ponderosae] -- -- -- -- -- K10842 MNAT1 CDK-activating kinase assembly factor MAT1 http://www.genome.jp/dbget-bin/www_bget?ko:K10842 P51950 738 8.8e-77 CDK-activating kinase assembly factor MAT1 OS=Marthasterias glacialis PE=1 SV=1 PF06391//PF13639//PF01496//PF17121//PF00097//PF14634//PF03854 CDK-activating kinase assembly factor MAT1//Ring finger domain//V-type ATPase 116kDa subunit family//Zinc finger, C3HC4 type (RING finger)//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//P-11 zinc finger GO:0015992//GO:0007049//GO:0015991 proton transport//cell cycle//ATP hydrolysis coupled proton transport GO:0046872//GO:0008270//GO:0015078//GO:0005515//GO:0003723 metal ion binding//zinc ion binding//hydrogen ion transmembrane transporter activity//protein binding//RNA binding GO:0033179//GO:0005634 proton-transporting V-type ATPase, V0 domain//nucleus KOG3800 Predicted E3 ubiquitin ligase containing RING finger, subunit of transcription/repair factor TFIIH and CDK-activating kinase assembly factor Cluster-8309.55986 BF_2 399.57 2.84 6177 91080811 XP_970116.1 1778 2.7e-195 PREDICTED: ufm1-specific protease 2 [Tribolium castaneum]>gi|270005426|gb|EFA01874.1| hypothetical protein TcasGA2_TC007479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M1D1 1045 1.1e-111 Probable Ufm1-specific protease 2 OS=Drosophila pseudoobscura pseudoobscura GN=UFSP2 PE=3 SV=1 PF03847//PF00125//PF00089//PF02285 Transcription initiation factor TFIID subunit A//Core histone H2A/H2B/H3/H4//Trypsin//Cytochrome oxidase c subunit VIII GO:0006508//GO:0006352//GO:0015992//GO:0006123 proteolysis//DNA-templated transcription, initiation//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004252//GO:0004129//GO:0003677 serine-type endopeptidase activity//cytochrome-c oxidase activity//DNA binding GO:0005669//GO:0045277 transcription factor TFIID complex//respiratory chain complex IV KOG2433 Uncharacterized conserved protein Cluster-8309.55989 BF_2 42.75 0.81 2489 642929013 XP_008195655.1 1308 3.4e-141 PREDICTED: 4-hydroxybenzoate polyprenyltransferase, mitochondrial [Tribolium castaneum] 759111195 XM_011357078.1 51 5.01582e-15 PREDICTED: Pteropus vampyrus protein-O-mannosyltransferase 2 (POMT2), transcript variant X2, mRNA K06125 COQ2 4-hydroxybenzoate polyprenyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06125 Q16QL3 1096 5.4e-118 4-hydroxybenzoate polyprenyltransferase, mitochondrial OS=Aedes aegypti GN=coq2 PE=3 SV=1 PF03419//PF01040//PF02366 Sporulation factor SpoIIGA//UbiA prenyltransferase family//Dolichyl-phosphate-mannose-protein mannosyltransferase GO:0030436//GO:0006508//GO:0006493 asexual sporulation//proteolysis//protein O-linked glycosylation GO:0000030//GO:0004659//GO:0004190 mannosyltransferase activity//prenyltransferase activity//aspartic-type endopeptidase activity GO:0016020//GO:0016021//GO:0000136 membrane//integral component of membrane//alpha-1,6-mannosyltransferase complex KOG1381 Para-hydroxybenzoate-polyprenyl transferase Cluster-8309.55990 BF_2 445.00 12.50 1776 91085075 XP_967088.1 1602 2.0e-175 PREDICTED: lethal(2)neighbour of tid protein [Tribolium castaneum]>gi|270009042|gb|EFA05490.1| hypothetical protein TcasGA2_TC015675 [Tribolium castaneum] -- -- -- -- -- K03845 ALG3 alpha-1,3-mannosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03845 Q27333 1152 1.2e-124 Lethal(2)neighbour of tid protein OS=Drosophila melanogaster GN=l(2)not PE=1 SV=1 PF05208//PF15202 ALG3 protein//Adipogenin GO:0045444 fat cell differentiation GO:0016758 transferase activity, transferring hexosyl groups GO:0016021//GO:0005783 integral component of membrane//endoplasmic reticulum KOG2762 Mannosyltransferase Cluster-8309.55991 BF_2 60.58 1.65 1826 91094277 XP_970700.1 1463 2.7e-159 PREDICTED: arfaptin-2 [Tribolium castaneum]>gi|270014395|gb|EFA10843.1| hypothetical protein TcasGA2_TC001620 [Tribolium castaneum] 807015662 XM_004517862.2 67 4.66887e-24 PREDICTED: Ceratitis capitata arfaptin-2 (LOC101461303), transcript variant X3, mRNA -- -- -- -- P53365 853 6.0e-90 Arfaptin-2 OS=Homo sapiens GN=ARFIP2 PE=1 SV=1 PF06456//PF03114//PF05823 Arfaptin-like domain//BAR domain//Nematode fatty acid retinoid binding protein (Gp-FAR-1) -- -- GO:0008289//GO:0019904//GO:0005515 lipid binding//protein domain specific binding//protein binding GO:0005737 cytoplasm KOG3651 Protein kinase C, alpha binding protein Cluster-8309.55992 BF_2 41.35 1.08 1887 91087367 XP_975633.1 403 2.3e-36 PREDICTED: protein PRRC1-A-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3T1I4 200 3.2e-14 Protein PRRC1 OS=Rattus norvegicus GN=Prrc1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.55993 BF_2 79.65 0.86 4173 270003038 EEZ99485.1 772 8.2e-79 hypothetical protein TcasGA2_TC000060 [Tribolium castaneum] -- -- -- -- -- K00791 miaA, TRIT1 tRNA dimethylallyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00791 Q9H3H1 545 7.1e-54 tRNA dimethylallyltransferase, mitochondrial OS=Homo sapiens GN=TRIT1 PE=1 SV=1 PF00931//PF00910//PF01715//PF01637//PF04851//PF06414//PF00096//PF07728//PF01745//PF07475 NB-ARC domain//RNA helicase//IPP transferase//Archaeal ATPase//Type III restriction enzyme, res subunit//Zeta toxin//Zinc finger, C2H2 type//AAA domain (dynein-related subfamily)//Isopentenyl transferase//HPr Serine kinase C-terminal domain GO:0016310//GO:0006694//GO:0008033//GO:0009058//GO:0016114//GO:0006109//GO:0000160 phosphorylation//steroid biosynthetic process//tRNA processing//biosynthetic process//terpenoid biosynthetic process//regulation of carbohydrate metabolic process//phosphorelay signal transduction system GO:0004672//GO:0003724//GO:0046872//GO:0043531//GO:0003723//GO:0003677//GO:0004161//GO:0016301//GO:0016887//GO:0005524//GO:0000155//GO:0016787 protein kinase activity//RNA helicase activity//metal ion binding//ADP binding//RNA binding//DNA binding//dimethylallyltranstransferase activity//kinase activity//ATPase activity//ATP binding//phosphorelay sensor kinase activity//hydrolase activity GO:0009365 protein histidine kinase complex KOG1384 tRNA delta(2)-isopentenylpyrophosphate transferase Cluster-8309.55994 BF_2 1.00 0.62 350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.55998 BF_2 22.00 1.49 906 795362492 XP_011747844.1 227 2.8e-16 PREDICTED: proto-oncogene tyrosine-protein kinase receptor Ret isoform X2 [Macaca nemestrina] 336042955 JF276429.1 906 0 Homo sapiens genotype p.C634Y ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 227 1.2e-17 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56000 BF_2 12.90 0.45 1474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14978 Mitochondrial ribosome protein 63 -- -- -- -- GO:0005761 mitochondrial ribosome -- -- Cluster-8309.56001 BF_2 2.00 0.50 453 759058480 XP_011338475.1 263 9.3e-21 PREDICTED: uncharacterized protein LOC105280011 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08220//PF00292 DeoR-like helix-turn-helix domain//'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.56003 BF_2 203.49 1.27 6971 478250833 ENN71323.1 1201 2.5e-128 hypothetical protein YQE_11983, partial [Dendroctonus ponderosae]>gi|478259213|gb|ENN79116.1| hypothetical protein YQE_04427, partial [Dendroctonus ponderosae] 642918718 XM_008193332.1 144 2.83637e-66 PREDICTED: Tribolium castaneum zinc finger protein jing homolog (LOC658276), transcript variant X2, mRNA K17452 AEBP2 zinc finger protein AEBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K17452 Q17PR1 641 8.8e-65 Zinc finger protein jing homolog OS=Aedes aegypti GN=AAEL000263 PE=3 SV=1 PF00096//PF13465//PF16622//PF05399 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//Ectropic viral integration site 2A protein (EVI2A) -- -- GO:0046872 metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.56008 BF_2 3.00 0.43 581 642912101 XP_008200805.1 314 1.5e-26 PREDICTED: V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K02154 ATPeV0A, ATP6N V-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02154 Q920R6 185 5.5e-13 V-type proton ATPase 116 kDa subunit a isoform 4 OS=Mus musculus GN=Atp6v0a4 PE=2 SV=1 PF01496 V-type ATPase 116kDa subunit family GO:0015991//GO:0015992 ATP hydrolysis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033179 proton-transporting V-type ATPase, V0 domain KOG2189 Vacuolar H+-ATPase V0 sector, subunit a Cluster-8309.56010 BF_2 19.00 1.55 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56016 BF_2 12.04 1.01 786 642922229 XP_008193071.1 429 9.2e-40 PREDICTED: thiamine transporter 2-like [Tribolium castaneum]>gi|270007226|gb|EFA03674.1| hypothetical protein TcasGA2_TC013776 [Tribolium castaneum] -- -- -- -- -- K14610 SLC19A2_3, THTR solute carrier family 19 (thiamine transporter), member 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14610 O60779 243 1.4e-19 Thiamine transporter 1 OS=Homo sapiens GN=SLC19A2 PE=1 SV=2 PF01630//PF01770 Hyaluronidase//Reduced folate carrier GO:0006810//GO:0005975 transport//carbohydrate metabolic process GO:0005542//GO:0008518//GO:0004415 folic acid binding//reduced folate carrier activity//hyalurononglucosaminidase activity GO:0016020 membrane KOG3810 Micronutrient transporters (folate transporter family) Cluster-8309.56024 BF_2 87.35 0.58 6632 478256920 ENN77089.1 1981 8.4e-219 hypothetical protein YQE_06424, partial [Dendroctonus ponderosae] -- -- -- -- -- K09257 NFKBIL2 NF-kappa-B inhibitor-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K09257 Q9VSA4 748 3.3e-77 Tonsoku-like protein OS=Drosophila melanogaster GN=CG7457 PE=1 SV=1 PF13606//PF13181//PF13174//PF13374//PF00515//PF02827//PF00023//PF13176//PF13414 Ankyrin repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Ankyrin repeat//Tetratricopeptide repeat//TPR repeat GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG4177 Ankyrin Cluster-8309.56026 BF_2 306.35 3.22 4266 478252382 ENN72808.1 713 5.8e-72 hypothetical protein YQE_10612, partial [Dendroctonus ponderosae]>gi|546680716|gb|ERL90942.1| hypothetical protein D910_08284 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q6P0C6 362 1.2e-32 Lipoma HMGIC fusion partner-like 2 protein OS=Danio rerio GN=lhfpl2 PE=2 SV=1 PF03161//PF13903 LAGLIDADG DNA endonuclease family//PMP-22/EMP/MP20/Claudin tight junction -- -- GO:0004519 endonuclease activity GO:0016021 integral component of membrane KOG4450 Uncharacterized conserved protein Cluster-8309.5603 BF_2 4.00 0.41 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56031 BF_2 61.40 7.26 641 270012816 EFA09264.1 343 7.0e-30 matrix metalloproteinase 2 [Tribolium castaneum] -- -- -- -- -- K07993 MMP11 matrix metalloproteinase-11 (stromelysin 3) http://www.genome.jp/dbget-bin/www_bget?ko:K07993 Q02853 217 1.2e-16 Stromelysin-3 OS=Mus musculus GN=Mmp11 PE=1 SV=2 PF04726 Microvirus J protein -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.56033 BF_2 106.94 0.60 7686 805759871 XP_012153123.1 3655 0.0e+00 PREDICTED: uncharacterized protein LOC100877606 isoform X2 [Megachile rotundata] 805759873 XM_012297744.1 247 1.72981e-123 PREDICTED: Megachile rotundata uncharacterized LOC100877606 (LOC100877606), transcript variant X5, mRNA -- -- -- -- Q5DU57 1154 3.2e-124 Spermatogenesis-associated protein 13 OS=Mus musculus GN=Spata13 PE=2 SV=2 PF00621//PF00018//PF14604 RhoGEF domain//SH3 domain//Variant SH3 domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005515//GO:0005089 protein binding//Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.56034 BF_2 3.00 0.35 641 478263091 ENN81487.1 141 1.9e-06 hypothetical protein YQE_02109, partial [Dendroctonus ponderosae]>gi|546685975|gb|ERL95386.1| hypothetical protein D910_12650 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56035 BF_2 9.00 0.53 998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56037 BF_2 41.49 0.58 3300 546676105 ERL87172.1 1376 6.0e-149 hypothetical protein D910_04572, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7K175 535 8.1e-53 Small RNA 2'-O-methyltransferase OS=Drosophila melanogaster GN=Hen1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1045 Uncharacterized conserved protein HEN1/CORYMBOSA2 Cluster-8309.56040 BF_2 23.35 2.79 637 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03490 Variant-surface-glycoprotein phospholipase C GO:0006650 glycerophospholipid metabolic process GO:0047396 glycosylphosphatidylinositol diacylglycerol-lyase activity -- -- -- -- Cluster-8309.56045 BF_2 12.00 2.74 470 478259605 ENN79458.1 161 6.5e-09 hypothetical protein YQE_04102, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05887//PF01607 Procyclic acidic repetitive protein (PARP)//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.56047 BF_2 67.85 0.96 3237 478251865 ENN72304.1 1079 1.6e-114 hypothetical protein YQE_11047, partial [Dendroctonus ponderosae] 645007963 XM_008205563.1 179 4.5794e-86 PREDICTED: Nasonia vitripennis SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (LOC100118240), transcript variant X4, mRNA K11648 SMARCB1, SNF5, INI1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11648 Q6DFM1 881 6.0e-93 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 OS=Xenopus tropicalis GN=smarcb1 PE=2 SV=1 PF04855//PF08039 SNF5 / SMARCB1 / INI1//Mitochondrial proteolipid GO:0006338 chromatin remodeling -- -- GO:0000228//GO:0005739 nuclear chromosome//mitochondrion KOG1649 SWI-SNF chromatin remodeling complex, Snf5 subunit Cluster-8309.56048 BF_2 137.00 3.73 1824 478249887 ENN70394.1 825 2.6e-85 hypothetical protein YQE_12900, partial [Dendroctonus ponderosae]>gi|546683393|gb|ERL93212.1| hypothetical protein D910_10508 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BZD2 379 5.5e-35 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.56049 BF_2 5.20 0.41 824 817061840 XP_012252542.1 492 4.8e-47 PREDICTED: single-stranded DNA-binding protein 3 isoform X2 [Athalia rosae] 632963550 XM_007899757.1 102 7.20256e-44 PREDICTED: Callorhinchus milii single-stranded DNA binding protein 2 (ssbp2), transcript variant X2, mRNA -- -- -- -- Q9D032 412 3.7e-39 Single-stranded DNA-binding protein 3 OS=Mus musculus GN=Ssbp3 PE=1 SV=2 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG4594 Sequence-specific single-stranded-DNA-binding protein Cluster-8309.5605 BF_2 105.59 3.48 1557 642936948 XP_008198624.1 1496 3.4e-163 PREDICTED: transmembrane protein 39A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NV64 686 1.2e-70 Transmembrane protein 39A OS=Homo sapiens GN=TMEM39A PE=2 SV=1 PF05375 Pacifastin inhibitor (LCMII) -- -- GO:0030414 peptidase inhibitor activity -- -- KOG3828 Uncharacterized conserved protein Cluster-8309.56050 BF_2 129.00 5.94 1196 642913023 XP_008201355.1 1064 3.3e-113 PREDICTED: vacuolar protein sorting-associated protein 72 homolog [Tribolium castaneum] 815809469 XM_012370186.1 67 3.02655e-24 PREDICTED: Linepithema humile vacuolar protein sorting-associated protein 72 homolog (LOC105674081), mRNA K11664 VPS72, TCFL1, YL1 vacuolar protein sorting-associated protein 72 http://www.genome.jp/dbget-bin/www_bget?ko:K11664 Q9VKM6 615 1.6e-62 Vacuolar protein sorting-associated protein 72 homolog OS=Drosophila melanogaster GN=YL-1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2897 DNA-binding protein YL1 and related proteins Cluster-8309.56054 BF_2 12.16 0.97 814 332374018 AEE62150.1 317 9.2e-27 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56055 BF_2 26.99 0.90 1541 642936495 XP_008198460.1 253 4.6e-19 PREDICTED: protein tantalus isoform X2 [Tribolium castaneum]>gi|642936497|ref|XP_008198461.1| PREDICTED: protein tantalus isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56056 BF_2 28.21 0.39 3310 225542826 ACN91296.1 308 4.2e-25 dentin sialophosphoprotein precursor [Ateles geoffroyi] -- -- -- -- -- -- -- -- -- Q9NZW4 273 2.0e-22 Dentin sialophosphoprotein OS=Homo sapiens GN=DSPP PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.5606 BF_2 4.00 0.91 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56060 BF_2 25.54 0.51 2370 91084077 XP_968062.1 675 8.3e-68 PREDICTED: protein odr-4 homolog [Tribolium castaneum]>gi|270008008|gb|EFA04456.1| hypothetical protein TcasGA2_TC014760 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5SWX8 277 4.8e-23 Protein odr-4 homolog OS=Homo sapiens GN=ODR4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56062 BF_2 89.28 1.53 2723 642933410 XP_008197405.1 2316 4.9e-258 PREDICTED: sodium-independent sulfate anion transporter isoform X2 [Tribolium castaneum] 644991717 XM_001603675.3 264 2.15551e-133 PREDICTED: Nasonia vitripennis sodium-independent sulfate anion transporter (LOC100120043), mRNA K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 959 4.6e-102 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.56067 BF_2 1.21 0.36 427 642911061 XP_008200558.1 364 1.7e-32 PREDICTED: muscle calcium channel subunit alpha-1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56069 BF_2 39.38 1.99 1116 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11429//PF08702 Colicin D//Fibrinogen alpha/beta chain family GO:0051252//GO:0030168//GO:0051258//GO:0007165 regulation of RNA metabolic process//platelet activation//protein polymerization//signal transduction GO:0005102//GO:0030674//GO:0004540 receptor binding//protein binding, bridging//ribonuclease activity GO:0005577 fibrinogen complex -- -- Cluster-8309.56073 BF_2 46.80 0.54 3917 861633222 KMQ90883.1 149 1.3e-06 hypothetical protein RF55_9309 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56075 BF_2 217.12 2.54 3862 642938167 XP_008190994.1 699 2.2e-70 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXD9 202 3.9e-14 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF00002//PF06652//PF00001 7 transmembrane receptor (Secretin family)//Methuselah N-terminus//7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0006950 G-protein coupled receptor signaling pathway//response to stress GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.56081 BF_2 62.00 0.48 5714 532099958 XP_005335610.1 341 1.1e-28 PREDICTED: zinc finger protein 878-like [Ictidomys tridecemlineatus] 642938230 XM_964647.2 40 1.51145e-08 PREDICTED: Tribolium castaneum scratch 2 (LOC658241), mRNA K09219 SCRT scratch http://www.genome.jp/dbget-bin/www_bget?ko:K09219 Q9P2J8 328 1.4e-28 Zinc finger protein 624 OS=Homo sapiens GN=ZNF624 PE=1 SV=3 PF00096//PF01155//PF05495//PF02892//PF13912//PF16622//PF05191//PF13465//PF07975 Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//CHY zinc finger//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type//Adenylate kinase, active site lid//Zinc-finger double domain//TFIIH C1-like domain GO:0006144//GO:0046034//GO:0006281//GO:0006464 purine nucleobase metabolic process//ATP metabolic process//DNA repair//cellular protein modification process GO:0004017//GO:0046872//GO:0008270//GO:0016151//GO:0003677 adenylate kinase activity//metal ion binding//zinc ion binding//nickel cation binding//DNA binding -- -- -- -- Cluster-8309.56084 BF_2 10.00 0.39 1366 861626561 KMQ88832.1 1031 2.5e-109 tigger transposable element-derived protein 6-like protein, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF03184 helix-turn-helix, Psq domain//DDE superfamily endonuclease -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.56086 BF_2 183.50 6.38 1490 91081125 XP_975535.1 1034 1.2e-109 PREDICTED: protein YIPF6 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28CH8 675 2.1e-69 Protein YIPF6 OS=Xenopus tropicalis GN=yipf6 PE=2 SV=1 PF04893 Yip1 domain -- -- -- -- GO:0016020 membrane KOG2946 Uncharacterized conserved protein Cluster-8309.56089 BF_2 10.75 0.31 1749 91080251 XP_973223.1 235 6.4e-17 PREDICTED: 4-nitrophenylphosphatase [Tribolium castaneum]>gi|270005691|gb|EFA02139.1| hypothetical protein TcasGA2_TC007789 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q00472 154 6.5e-09 4-nitrophenylphosphatase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=pho2 PE=4 SV=2 -- -- -- -- -- -- -- -- KOG2882 p-Nitrophenyl phosphatase Cluster-8309.56093 BF_2 20.82 0.51 1993 91079971 XP_969899.1 654 1.9e-65 PREDICTED: beta-1,3-galactosyltransferase 5 [Tribolium castaneum]>gi|270004606|gb|EFA01054.1| hypothetical protein TcasGA2_TC003970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N293 325 1.1e-28 Beta-1,3-galactosyltransferase 5 (Fragment) OS=Gorilla gorilla gorilla GN=B3GALT5 PE=3 SV=2 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0016757//GO:0008378 transferase activity, transferring glycosyl groups//galactosyltransferase activity GO:0016020 membrane -- -- Cluster-8309.56094 BF_2 36.15 0.95 1873 91079971 XP_969899.1 654 1.8e-65 PREDICTED: beta-1,3-galactosyltransferase 5 [Tribolium castaneum]>gi|270004606|gb|EFA01054.1| hypothetical protein TcasGA2_TC003970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N293 325 1.0e-28 Beta-1,3-galactosyltransferase 5 (Fragment) OS=Gorilla gorilla gorilla GN=B3GALT5 PE=3 SV=2 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.56095 BF_2 12.00 0.38 1617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56099 BF_2 16.66 1.15 893 91084489 XP_971806.1 511 3.2e-49 PREDICTED: uncharacterized protein LOC660485 [Tribolium castaneum]>gi|270008675|gb|EFA05123.1| hypothetical protein TcasGA2_TC015238 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56107 BF_2 22.49 0.91 1325 270016479 EFA12925.1 852 1.4e-88 hypothetical protein TcasGA2_TC006978 [Tribolium castaneum] 642939405 XM_008195063.1 202 3.02426e-99 PREDICTED: Tribolium castaneum uncharacterized LOC661130 (LOC661130), mRNA -- -- -- -- Q61830 178 8.1e-12 Macrophage mannose receptor 1 OS=Mus musculus GN=Mrc1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56113 BF_2 1.00 1.96 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56114 BF_2 10.00 0.57 1019 752863744 XP_011268239.1 155 7.0e-08 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56117 BF_2 3.00 0.98 414 546672885 ERL84608.1 151 8.3e-08 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56121 BF_2 1.00 0.94 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56127 BF_2 8.00 0.50 958 546672885 ERL84608.1 682 5.1e-69 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P12276 279 1.1e-23 Fatty acid synthase OS=Gallus gallus GN=FASN PE=1 SV=5 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.56129 BF_2 151.48 4.06 1849 546683303 ERL93135.1 687 2.6e-69 hypothetical protein D910_10435 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P13582 476 3.2e-46 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.56132 BF_2 12.00 2.85 463 332224638 XP_003261475.1 430 4.1e-40 PREDICTED: smoothened homolog [Nomascus leucogenys] 11386323 AC083866.2 463 0 AC083866 Homo sapiens chromosome 7 clone RP11-702D16, complete sequence K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 Q99835 396 1.5e-37 Smoothened homolog OS=Homo sapiens GN=SMO PE=1 SV=1 PF01392 Fz domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56137 BF_2 123.85 0.86 6299 642922990 XP_008200484.1 2247 1.1e-249 PREDICTED: retinal guanylyl cyclase 2-like [Tribolium castaneum] 815917749 XM_012388519.1 208 6.7778e-102 PREDICTED: Bombus impatiens retinal guanylyl cyclase 2 (LOC100741981), transcript variant X5, mRNA K12321 GUCY2D_E_F guanylate cyclase 2D/E/F http://www.genome.jp/dbget-bin/www_bget?ko:K12321 O19179 1085 2.6e-116 Retinal guanylyl cyclase 1 OS=Canis familiaris GN=GUCY2D PE=2 SV=1 PF07701//PF00211//PF07714 Heme NO binding associated//Adenylate and Guanylate cyclase catalytic domain//Protein tyrosine kinase GO:0006182//GO:0046039//GO:0006144//GO:0006468//GO:0035556//GO:0009190 cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process//protein phosphorylation//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0004383//GO:0004672//GO:0016849 guanylate cyclase activity//protein kinase activity//phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.56138 BF_2 10.00 0.73 859 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03864//PF00171 Phage major capsid protein E//Aldehyde dehydrogenase family GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity GO:0019028 viral capsid -- -- Cluster-8309.56144 BF_2 11.00 0.98 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56146 BF_2 7.00 0.77 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56148 BF_2 194.00 15.40 814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080 Presenilin -- -- GO:0004190 aspartic-type endopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-8309.56153 BF_2 5.00 0.40 816 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56158 BF_2 286.38 14.44 1117 546683404 ERL93223.1 143 1.9e-06 hypothetical protein D910_10519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03427//PF01093 Carbohydrate binding domain (family 19)//Clusterin GO:0008219//GO:0006032 cell death//chitin catabolic process GO:0008061 chitin binding -- -- -- -- Cluster-8309.56161 BF_2 9.00 1.25 589 156385450 XP_001633643.1 364 2.4e-32 predicted protein [Nematostella vectensis]>gi|156220716|gb|EDO41580.1| predicted protein [Nematostella vectensis] 115453872 NM_001057072.1 589 0 Oryza sativa Japonica Group Os03g0576700 (Os03g0576700) mRNA, complete cds >gnl|BL_ORD_ID|3397609 Oryza sativa Japonica Group cDNA clone:006-309-G09, full insert sequence K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 P41129 497 3.7e-49 60S ribosomal protein L13-2 OS=Brassica napus PE=2 SV=1 PF05896//PF01294 Na(+)-translocating NADH-quinone reductase subunit A (NQRA)//Ribosomal protein L13e GO:0055114//GO:0042254//GO:0006814//GO:0006118//GO:0006412 oxidation-reduction process//ribosome biogenesis//sodium ion transport//obsolete electron transport//translation GO:0016655//GO:0003735 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//structural constituent of ribosome GO:0005622//GO:0030529//GO:0005840 intracellular//intracellular ribonucleoprotein complex//ribosome KOG3295 60S Ribosomal protein L13 Cluster-8309.56165 BF_2 17.51 0.60 1518 642928567 XP_008199961.1 577 1.2e-56 PREDICTED: probable cytochrome P450 12a4, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- K15004 CYP12 cytochrome P450, family 12 http://www.genome.jp/dbget-bin/www_bget?ko:K15004 O18635 418 1.4e-39 Cytochrome P450 CYP12A2 OS=Musca domestica GN=CYP12A2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.56168 BF_2 14.41 1.06 856 657569009 XP_008287965.1 145 8.5e-07 PREDICTED: sushi domain-containing protein 4-like [Stegastes partitus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56170 BF_2 25.44 0.65 1914 270001095 EEZ97542.1 150 5.0e-07 hypothetical protein TcasGA2_TC011392 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56172 BF_2 1.00 13.37 226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56175 BF_2 417.19 4.44 4215 478255350 ENN75576.1 1484 2.3e-161 hypothetical protein YQE_07919, partial [Dendroctonus ponderosae] -- -- -- -- -- K18328 DBR1 lariat debranching enzyme http://www.genome.jp/dbget-bin/www_bget?ko:K18328 Q9VSD7 1226 7.7e-133 Lariat debranching enzyme OS=Drosophila melanogaster GN=ldbr PE=1 SV=1 PF05011//PF00149//PF01507 Lariat debranching enzyme, C-terminal domain//Calcineurin-like phosphoesterase//Phosphoadenosine phosphosulfate reductase family GO:0008152//GO:0006397 metabolic process//mRNA processing GO:0003824//GO:0016788//GO:0016787 catalytic activity//hydrolase activity, acting on ester bonds//hydrolase activity -- -- KOG2863 RNA lariat debranching enzyme Cluster-8309.56176 BF_2 7.00 1.27 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56179 BF_2 141.36 3.68 1893 642935798 XP_008198179.1 397 1.1e-35 PREDICTED: CD63 antigen [Tribolium castaneum]>gi|270013280|gb|EFA09728.1| hypothetical protein TcasGA2_TC011861 [Tribolium castaneum] -- -- -- -- -- K06489 CD53, MOX44, TSPAN25 CD53 antigen http://www.genome.jp/dbget-bin/www_bget?ko:K06489 Q3ZCD0 149 2.7e-08 CD81 antigen OS=Bos taurus GN=CD81 PE=2 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.5618 BF_2 30.00 1.22 1319 270014282 EFA10730.1 817 1.6e-84 hypothetical protein TcasGA2_TC012313 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00023//PF13606//PF06766 Ankyrin repeat//Ankyrin repeat//Fungal hydrophobin -- -- GO:0005515 protein binding GO:0005576 extracellular region KOG4177 Ankyrin Cluster-8309.56183 BF_2 5.67 0.70 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- B7Z0K8 123 9.1e-06 Collagen alpha chain CG42342 OS=Drosophila melanogaster GN=CG42342 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56186 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56190 BF_2 10.57 0.57 1062 91080251 XP_973223.1 192 3.8e-12 PREDICTED: 4-nitrophenylphosphatase [Tribolium castaneum]>gi|270005691|gb|EFA02139.1| hypothetical protein TcasGA2_TC007789 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.56196 BF_2 103.00 1.64 2920 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56198 BF_2 121.63 2.71 2162 572271659 XP_006613765.1 1557 4.0e-170 PREDICTED: serine/threonine-protein phosphatase 5-like [Apis dorsata] 817223205 XM_012431486.1 171 8.52319e-82 PREDICTED: Orussus abietinus serine/threonine-protein phosphatase 5 (LOC105703243), transcript variant X2, mRNA K04460 PPP5C serine/threonine-protein phosphatase 5 http://www.genome.jp/dbget-bin/www_bget?ko:K04460 P53041 1311 5.5e-143 Serine/threonine-protein phosphatase 5 OS=Homo sapiens GN=PPP5C PE=1 SV=1 PF13174//PF10579//PF13181//PF13414//PF13176//PF13371//PF00515//PF00149 Tetratricopeptide repeat//Rapsyn N-terminal myristoylation and linker region//Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Calcineurin-like phosphoesterase GO:0007268 synaptic transmission GO:0033130//GO:0016787//GO:0043495//GO:0005515 acetylcholine receptor binding//hydrolase activity//protein anchor//protein binding -- -- KOG0376 Serine-threonine phosphatase 2A, catalytic subunit Cluster-8309.56199 BF_2 25.93 0.48 2533 642920863 XP_008192590.1 1763 6.1e-194 PREDICTED: protein turtle isoform X5 [Tribolium castaneum] 642920870 XM_008194372.1 180 9.93928e-87 PREDICTED: Tribolium castaneum protein turtle (LOC662186), transcript variant X14, mRNA -- -- -- -- Q967D7 503 3.2e-49 Protein turtle OS=Drosophila melanogaster GN=tutl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56202 BF_2 24.75 0.35 3250 546679741 ERL90152.1 1446 4.5e-157 hypothetical protein D910_07506 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BKN5 406 7.3e-38 Gamma-tubulin complex component 5 OS=Mus musculus GN=Tubgcp5 PE=2 SV=2 PF01222//PF04130 Ergosterol biosynthesis ERG4/ERG24 family//Spc97 / Spc98 family GO:0000226//GO:0090063 microtubule cytoskeleton organization//positive regulation of microtubule nucleation -- -- GO:0005815//GO:0000922//GO:0016020 microtubule organizing center//spindle pole//membrane -- -- Cluster-8309.56208 BF_2 576.52 58.84 697 584482886 AHJ09940.1 1022 1.4e-108 glycoside hydrolase family 28 [Apriona japonica] 584482885 KF724642.1 603 0 Apriona japonica glycoside hydrolase family 28 (gh28-2) mRNA, complete cds -- -- -- -- A2R8F8 430 2.6e-41 Probable endopolygalacturonase A OS=Aspergillus niger (strain CBS 513.88 / FGSC A1513) GN=pgaA PE=3 SV=1 PF00295 Glycosyl hydrolases family 28 GO:0005985//GO:0005982//GO:0005975 sucrose metabolic process//starch metabolic process//carbohydrate metabolic process GO:0004650 polygalacturonase activity -- -- -- -- Cluster-8309.56211 BF_2 7.00 0.56 812 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56216 BF_2 22.00 1.70 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56219 BF_2 82.83 1.54 2535 189240243 XP_969276.2 786 1.2e-80 PREDICTED: homeobox protein unc-4-like [Tribolium castaneum] 830020422 XM_012759459.1 72 1.08286e-26 PREDICTED: Microcebus murinus UNC homeobox (UNCX), mRNA K09328 UNC4 homeobox protein Unc-4 http://www.genome.jp/dbget-bin/www_bget?ko:K09328 O77215 467 4.8e-45 Homeobox protein unc-4 OS=Drosophila melanogaster GN=unc-4 PE=2 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.56222 BF_2 39.92 0.50 3646 478255459 ENN75680.1 902 6.1e-94 hypothetical protein YQE_07778, partial [Dendroctonus ponderosae] -- -- -- -- -- K04729 MYD88 myeloid differentiation primary response protein MyD88 http://www.genome.jp/dbget-bin/www_bget?ko:K04729 A8QMS7 316 2.2e-27 Myeloid differentiation primary response protein MyD88 OS=Takifugu rubripes GN=myd88 PE=2 SV=1 PF01582//PF13676//PF00531 TIR domain//TIR domain//Death domain GO:0007165 signal transduction GO:0005515 protein binding -- -- -- -- Cluster-8309.56225 BF_2 145.95 1.65 3994 642920495 XP_969255.3 1368 6.1e-148 PREDICTED: open rectifier potassium channel protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94526 709 6.5e-73 Open rectifier potassium channel protein 1 OS=Drosophila melanogaster GN=Ork1 PE=1 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.56226 BF_2 115.70 1.60 3313 546681111 ERL91267.1 1327 2.9e-143 hypothetical protein D910_08601 [Dendroctonus ponderosae] -- -- -- -- -- K04924 KCNK16 potassium channel subfamily K member 16 http://www.genome.jp/dbget-bin/www_bget?ko:K04924 Q94526 678 2.1e-69 Open rectifier potassium channel protein 1 OS=Drosophila melanogaster GN=Ork1 PE=1 SV=2 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.56228 BF_2 181.35 2.04 4000 642920495 XP_969255.3 1368 6.1e-148 PREDICTED: open rectifier potassium channel protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q94526 709 6.5e-73 Open rectifier potassium channel protein 1 OS=Drosophila melanogaster GN=Ork1 PE=1 SV=2 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.56232 BF_2 134.67 5.58 1296 642934029 XP_008197611.1 347 4.9e-30 PREDICTED: uncharacterized protein LOC662748 isoform X1 [Tribolium castaneum]>gi|642934031|ref|XP_008197613.1| PREDICTED: uncharacterized protein LOC662748 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56237 BF_2 17.72 0.31 2694 642919719 XP_008192036.1 1039 5.8e-110 PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919721|ref|XP_008192037.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|642919723|ref|XP_008192039.1| PREDICTED: glutaredoxin domain-containing cysteine-rich protein CG12206-like [Tribolium castaneum]>gi|270005423|gb|EFA01871.1| hypothetical protein TcasGA2_TC007476 [Tribolium castaneum] -- -- -- -- -- K17479 GRXCR1 glutaredoxin domain-containing cysteine-rich protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17479 Q9VNL4 798 2.1e-83 Glutaredoxin domain-containing cysteine-rich protein CG31559 OS=Drosophila melanogaster GN=CG31559 PE=1 SV=2 PF00462 Glutaredoxin GO:0006118//GO:0045454 obsolete electron transport//cell redox homeostasis GO:0015035//GO:0009055 protein disulfide oxidoreductase activity//electron carrier activity -- -- KOG2824 Glutaredoxin-related protein Cluster-8309.56239 BF_2 92.02 0.47 8472 332372792 AEE61538.1 1085 8.5e-115 unknown [Dendroctonus ponderosae] 805783396 XM_012284418.1 162 3.40188e-76 PREDICTED: Megachile rotundata tRNA (guanine-N(7)-)-methyltransferase (LOC100882994), transcript variant X3, mRNA K03439 trmB, METTL1 tRNA (guanine-N7-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03439 Q1HPU2 957 2.4e-101 tRNA (guanine-N(7)-)-methyltransferase OS=Bombyx mori PE=2 SV=1 PF13855//PF02390//PF00560//PF05175 Leucine rich repeat//Putative methyltransferase//Leucine Rich Repeat//Methyltransferase small domain GO:0006400//GO:0008033//GO:0009451 tRNA modification//tRNA processing//RNA modification GO:0005515//GO:0008168//GO:0008176 protein binding//methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity -- -- KOG3115 Methyltransferase-like protein Cluster-8309.56243 BF_2 420.06 9.22 2193 642919312 XP_008191821.1 1524 2.7e-166 PREDICTED: periodic tryptophan protein 1 homolog [Tribolium castaneum] 31222365 XM_317168.1 209 6.49834e-103 Anopheles gambiae str. PEST AGAP008298-PA (AgaP_AGAP008298) mRNA, complete cds K14791 PWP1 periodic tryptophan protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14791 Q13610 848 2.7e-89 Periodic tryptophan protein 1 homolog OS=Homo sapiens GN=PWP1 PE=1 SV=1 PF00085//PF01346//PF02966//PF00400 Thioredoxin//Domain amino terminal to FKBP-type peptidyl-prolyl isomerase//Mitosis protein DIM1//WD domain, G-beta repeat GO:0006457//GO:0045454//GO:0000398 protein folding//cell redox homeostasis//mRNA splicing, via spliceosome GO:0005515 protein binding GO:0005681 spliceosomal complex KOG0270 WD40 repeat-containing protein Cluster-8309.56245 BF_2 36.79 1.03 1783 642927980 XP_008195470.1 937 2.6e-98 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 473 6.8e-46 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF01585//PF00498 G-patch domain//FHA domain -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.56251 BF_2 276.91 5.60 2355 227018336 ACP18834.1 1341 4.9e-145 unknown [Chrysomela tremula] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16782 Nucleotide exchange factor SIL1 -- -- GO:0000774 adenyl-nucleotide exchange factor activity GO:0005783 endoplasmic reticulum -- -- Cluster-8309.56253 BF_2 8.00 2.29 433 795238015 XP_011808353.1 218 1.5e-15 PREDICTED: discoidin domain-containing receptor 2 [Colobus angolensis palliatus]>gi|795238024|ref|XP_011808354.1| PREDICTED: discoidin domain-containing receptor 2 [Colobus angolensis palliatus] 282721095 NG_016290.1 430 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 218 6.0e-17 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56254 BF_2 23.89 2.17 748 478263235 ENN81624.1 298 1.4e-24 hypothetical protein YQE_01987, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56262 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56263 BF_2 14.01 0.56 1333 91085531 XP_972280.1 791 1.6e-81 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 629 4.1e-64 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00795//PF04055 Carbon-nitrogen hydrolase//Radical SAM superfamily GO:0006807 nitrogen compound metabolic process GO:0003824//GO:0051536//GO:0016810 catalytic activity//iron-sulfur cluster binding//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0808 Carbon-nitrogen hydrolase Cluster-8309.56266 BF_2 121.07 3.01 1971 642931121 XP_008201670.1 549 2.8e-53 PREDICTED: autism susceptibility gene 2 protein isoform X5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56268 BF_2 60.00 0.43 6149 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02827 cAMP-dependent protein kinase inhibitor GO:0045859//GO:0006469 regulation of protein kinase activity//negative regulation of protein kinase activity GO:0004862 cAMP-dependent protein kinase inhibitor activity GO:0005952 cAMP-dependent protein kinase complex -- -- Cluster-8309.56269 BF_2 15.00 0.71 1165 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5627 BF_2 1.00 0.61 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56270 BF_2 1.00 0.60 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56273 BF_2 159.00 16.68 686 642930660 XP_001810176.2 428 1.0e-39 PREDICTED: coiled-coil domain-containing protein 115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56287 BF_2 52.19 0.55 4270 478262983 ENN81389.1 782 5.8e-80 hypothetical protein YQE_02205, partial [Dendroctonus ponderosae] -- -- -- -- -- K02321 POLA2 DNA polymerase alpha subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K02321 P33611 513 3.7e-50 DNA polymerase alpha subunit B OS=Mus musculus GN=Pola2 PE=1 SV=2 PF12122//PF04042 Cytoplasmic N-terminal domain of rhomboid serine protease//DNA polymerase alpha/epsilon subunit B GO:0006260 DNA replication GO:0003677//GO:0004252//GO:0003887 DNA binding//serine-type endopeptidase activity//DNA-directed DNA polymerase activity GO:0016021//GO:0042575 integral component of membrane//DNA polymerase complex KOG1625 DNA polymerase alpha-primase complex, polymerase-associated subunit B Cluster-8309.56289 BF_2 15.18 1.73 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56293 BF_2 21.05 0.39 2556 642916135 XP_008190901.1 765 3.3e-78 PREDICTED: PQ-loop repeat-containing protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N755 308 1.3e-26 PQ-loop repeat-containing protein 3 OS=Homo sapiens GN=PQLC3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3211 Predicted endoplasmic reticulum membrane protein Lec35/MPDU1 involved in monosaccharide-P-dolichol utilization Cluster-8309.56295 BF_2 36.04 0.50 3291 385199932 AFI45014.1 1346 1.8e-145 cytochrome P450 CYP411a1 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P29981 654 1.3e-66 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.56299 BF_2 60.35 0.34 7719 642921556 XP_008192422.1 4628 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TU53 2383 9.8e-267 Cubilin OS=Canis familiaris GN=CUBN PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.56300 BF_2 34.12 4.28 621 189237643 XP_966949.2 768 3.5e-79 PREDICTED: diphthine synthase [Tribolium castaneum] -- -- -- -- -- K00586 DPH5 diphthine synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00586 Q9H2P9 635 3.9e-65 Diphthine methyl ester synthase OS=Homo sapiens GN=DPH5 PE=1 SV=2 PF00590 Tetrapyrrole (Corrin/Porphyrin) Methylases GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG3123 Diphthine synthase Cluster-8309.56301 BF_2 13.28 8.35 349 546673559 ERL85134.1 307 5.7e-26 hypothetical protein D910_02556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O15027 143 2.4e-08 Protein transport protein Sec16A OS=Homo sapiens GN=SEC16A PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1913 Regucalcin gene promoter region-related protein (RGPR) Cluster-8309.56309 BF_2 4.00 31.08 240 -- -- -- -- -- 116012237 AK242872.1 240 3.64913e-121 Oryza sativa Japonica Group cDNA, clone: J090076M21, full insert sequence -- -- -- -- P14614 324 1.7e-29 Glutelin type-B 4 OS=Oryza sativa subsp. japonica GN=GLUB4 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56312 BF_2 6.07 0.36 1000 642922596 XP_970120.2 453 1.9e-42 PREDICTED: tRNA-dihydrouridine(20) synthase [NAD(P)+]-like [Tribolium castaneum] -- -- -- -- -- K05543 DUS2 tRNA-dihydrouridine synthase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05543 Q9D7B1 381 1.8e-35 tRNA-dihydrouridine(20) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus2 PE=1 SV=1 PF01207 Dihydrouridine synthase (Dus) GO:0055114//GO:0008033 oxidation-reduction process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity -- -- KOG2334 tRNA-dihydrouridine synthase Cluster-8309.56315 BF_2 11.48 1.53 600 642929078 XP_008195682.1 179 6.8e-11 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56317 BF_2 28.00 1.07 1380 642929078 XP_008195682.1 819 9.6e-85 PREDICTED: venom metalloproteinase 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WUQ1 168 1.2e-10 A disintegrin and metalloproteinase with thrombospondin motifs 1 OS=Rattus norvegicus GN=Adamts1 PE=2 SV=1 PF01083//PF01421//PF08516 Cutinase//Reprolysin (M12B) family zinc metalloprotease//ADAM cysteine-rich GO:0008152//GO:0006508 metabolic process//proteolysis GO:0004222//GO:0016787 metalloendopeptidase activity//hydrolase activity -- -- -- -- Cluster-8309.56319 BF_2 69.28 1.81 1889 642929081 XP_008195683.1 1459 8.1e-159 PREDICTED: venom metalloproteinase 3 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B5AJT4 177 1.5e-11 Venom metalloproteinase 3 OS=Eulophus pennicornis PE=2 SV=1 PF01562 Reprolysin family propeptide GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity -- -- -- -- Cluster-8309.56325 BF_2 2.00 0.48 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56326 BF_2 80.18 3.45 1260 478250982 ENN71466.1 428 1.9e-39 hypothetical protein YQE_11883, partial [Dendroctonus ponderosae]>gi|546682648|gb|ERL92560.1| hypothetical protein D910_09873 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56329 BF_2 42.00 0.49 3865 642934360 XP_008197626.1 2606 1.6e-291 PREDICTED: zinc finger protein 62 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P15620 463 2.1e-44 Zinc finger protein 271 OS=Mus musculus GN=Znf271 PE=2 SV=1 PF00096//PF13465//PF08416//PF04988//PF01215//PF16622//PF07012 Zinc finger, C2H2 type//Zinc-finger double domain//Phosphotyrosine-binding domain//A-kinase anchoring protein 95 (AKAP95)//Cytochrome c oxidase subunit Vb//zinc-finger C2H2-type//Curlin associated repeat GO:0015992//GO:0007155//GO:0006123 proton transport//cell adhesion//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0046872//GO:0005515//GO:0003677 cytochrome-c oxidase activity//metal ion binding//protein binding//DNA binding GO:0005740//GO:0045277//GO:0009289//GO:0005634 mitochondrial envelope//respiratory chain complex IV//pilus//nucleus -- -- Cluster-8309.56330 BF_2 56.94 0.58 4395 270005503 EFA01951.1 634 8.7e-63 hypothetical protein TcasGA2_TC007566 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56335 BF_2 4.00 0.46 649 546672885 ERL84608.1 314 1.6e-26 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P19096 205 2.9e-15 Fatty acid synthase OS=Mus musculus GN=Fasn PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.56338 BF_2 10.00 0.64 942 270014439 EFA10887.1 172 7.0e-10 hypothetical protein TcasGA2_TC001711 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00640//PF02777 Phosphotyrosine interaction domain (PTB/PID)//Iron/manganese superoxide dismutases, C-terminal domain GO:0006801//GO:0055114 superoxide metabolic process//oxidation-reduction process GO:0046872//GO:0005515//GO:0004784 metal ion binding//protein binding//superoxide dismutase activity -- -- -- -- Cluster-8309.56339 BF_2 614.53 17.30 1773 546684200 ERL93905.1 598 5.2e-59 hypothetical protein D910_11191 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00166 Chaperonin 10 Kd subunit GO:0006457 protein folding -- -- GO:0005737 cytoplasm -- -- Cluster-8309.56346 BF_2 432.77 3.99 4827 642937760 XP_008198934.1 1304 1.9e-140 PREDICTED: mortality factor 4-like protein 1 [Tribolium castaneum]>gi|270001152|gb|EEZ97599.1| hypothetical protein TcasGA2_TC011468 [Tribolium castaneum] 807018879 XM_004519732.2 70 2.68358e-25 PREDICTED: Ceratitis capitata nuA4 complex subunit EAF3 homolog (LOC101448544), mRNA K11339 MORF4L1, MRG15, EAF3 mortality factor 4-like protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11339 Q6AYU1 950 9.0e-101 Mortality factor 4-like protein 1 OS=Rattus norvegicus GN=Morf4l1 PE=2 SV=1 PF01080//PF05485 Presenilin//THAP domain -- -- GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0005634//GO:0016021 nucleus//integral component of membrane KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.56347 BF_2 4.00 0.50 620 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56349 BF_2 1.71 0.51 426 91081577 XP_975228.1 424 1.9e-39 PREDICTED: maltase 2 [Tribolium castaneum]>gi|270006189|gb|EFA02637.1| hypothetical protein TcasGA2_TC008358 [Tribolium castaneum] -- -- -- -- -- K14210 SLC3A1, RBAT solute carrier family 3 (neutral and basic amino acid transporter), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14210 P13080 351 2.3e-32 Probable maltase OS=Aedes aegypti GN=MAL1 PE=2 SV=1 PF00128 Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0003824//GO:0043169 catalytic activity//cation binding -- -- -- -- Cluster-8309.56359 BF_2 1.92 0.64 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5636 BF_2 2.00 0.79 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56362 BF_2 4.00 0.80 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56363 BF_2 33.28 0.51 3041 8648963 CAB94835.1 2359 5.7e-263 heterochromatin protein [Leptinotarsa decemlineata] 749745767 XM_011136632.1 88 1.65954e-35 PREDICTED: Harpegnathos saltator eukaryotic translation initiation factor 2 subunit 3, Y-linked (LOC105180525), mRNA K11419 SUV39H, CLR4 histone-lysine N-methyltransferase SUV39H http://www.genome.jp/dbget-bin/www_bget?ko:K11419 Q32PH7 758 1.0e-78 Histone-lysine N-methyltransferase SUV39H2 OS=Bos taurus GN=SUV39H2 PE=2 SV=1 PF00856//PF05033 SET domain//Pre-SET motif GO:0006479//GO:0034968//GO:0006554 protein methylation//histone lysine methylation//lysine catabolic process GO:0008270//GO:0018024//GO:0005515 zinc ion binding//histone-lysine N-methyltransferase activity//protein binding GO:0005634 nucleus KOG1082 Histone H3 (Lys9) methyltransferase SUV39H1/Clr4, required for transcriptional silencing Cluster-8309.56365 BF_2 81.00 4.34 1068 91083427 XP_969334.1 411 1.5e-37 PREDICTED: M-phase phosphoprotein 6 [Tribolium castaneum]>gi|270006891|gb|EFA03339.1| hypothetical protein TcasGA2_TC013316 [Tribolium castaneum] -- -- -- -- -- K12593 MPHOSPH6, MPP6 M-phase phosphoprotein 6, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K12593 Q9D1Q1 183 1.7e-12 M-phase phosphoprotein 6 OS=Mus musculus GN=Mphosph6 PE=1 SV=1 PF04615 Utp14 protein GO:0006364 rRNA processing -- -- GO:0032040 small-subunit processome -- -- Cluster-8309.56370 BF_2 43.97 0.88 2367 91084211 XP_968214.1 800 2.6e-82 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 313 3.2e-27 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56371 BF_2 295.26 7.86 1859 91084211 XP_968214.1 901 4.0e-94 PREDICTED: transcriptional adapter 3 [Tribolium castaneum]>gi|270008765|gb|EFA05213.1| hypothetical protein TcasGA2_TC015353 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66IZ5 351 9.9e-32 Transcriptional adapter 3-B OS=Xenopus laevis GN=tada3-b PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56372 BF_2 38.87 0.38 4575 642933730 XP_008197339.1 4424 0.0e+00 PREDICTED: transmembrane protein 132B-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K17599 TMEM132 transmembrane protein 132 http://www.genome.jp/dbget-bin/www_bget?ko:K17599 Q14DG7 701 6.3e-72 Transmembrane protein 132B OS=Homo sapiens GN=TMEM132B PE=2 SV=2 -- -- -- -- -- -- -- -- KOG4789 Uncharacterized conserved protein Cluster-8309.56373 BF_2 22.80 0.96 1285 642936409 XP_008198421.1 466 7.7e-44 PREDICTED: APOPT family protein CG14806, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q148E1 284 4.0e-24 Apoptogenic protein 1, mitochondrial OS=Bos taurus GN=APOPT1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4094 Uncharacterized conserved protein Cluster-8309.56375 BF_2 122.00 37.65 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56382 BF_2 19.10 1.18 966 795016637 XP_011858564.1 860 1.2e-89 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56383 BF_2 5.42 0.40 860 795016637 XP_011858564.1 631 3.8e-63 PREDICTED: uncharacterized protein LOC105556100 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56384 BF_2 119.82 1.18 4553 478257774 ENN77917.1 1941 2.5e-214 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- K17573 LKAP, MARF1 meiosis arrest female protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17573 E1BP74 764 3.1e-79 Meiosis arrest female protein 1 OS=Bos taurus GN=MARF1 PE=3 SV=2 PF02196//PF00076 Raf-like Ras-binding domain//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0007165 signal transduction GO:0003676//GO:0005057 nucleic acid binding//receptor signaling protein activity -- -- -- -- Cluster-8309.56385 BF_2 166.32 1.27 5766 478257774 ENN77917.1 2916 0.0e+00 hypothetical protein YQE_05594, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- B2GUN4 1110 3.0e-119 Meiosis arrest female protein 1 homolog OS=Xenopus tropicalis GN=marf1 PE=2 SV=1 PF00106//PF00076 short chain dehydrogenase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0008152 metabolic process GO:0003676//GO:0016491 nucleic acid binding//oxidoreductase activity -- -- -- -- Cluster-8309.56386 BF_2 66.40 0.63 4679 642928750 XP_008199767.1 2930 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 658 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- O60500 211 4.3e-15 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF00001//PF05808//PF13895 7 transmembrane receptor (rhodopsin family)//Podoplanin//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0005515 G-protein coupled receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.56388 BF_2 9.48 0.71 842 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56390 BF_2 5.00 0.64 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04616 Glycosyl hydrolases family 43 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.56394 BF_2 12.00 1.36 656 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56395 BF_2 11.56 0.66 1019 546672885 ERL84608.1 577 8.2e-57 hypothetical protein D910_02036 [Dendroctonus ponderosae] -- -- -- -- -- K00665 FASN fatty acid synthase, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K00665 P36189 473 3.9e-46 Fatty acid synthase (Fragment) OS=Anser anser anser GN=FASN PE=1 SV=1 PF05038//PF00211//PF05052//PF08545//PF00108 Cytochrome Cytochrome b558 alpha-subunit//Adenylate and Guanylate cyclase catalytic domain//MerE protein//3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III//Thiolase, N-terminal domain GO:0042967//GO:0008152//GO:0006633//GO:0035556//GO:0009190//GO:0015694 acyl-carrier-protein biosynthetic process//metabolic process//fatty acid biosynthetic process//intracellular signal transduction//cyclic nucleotide biosynthetic process//mercury ion transport GO:0004315//GO:0016747//GO:0016849//GO:0020037//GO:0015097 3-oxoacyl-[acyl-carrier-protein] synthase activity//transferase activity, transferring acyl groups other than amino-acyl groups//phosphorus-oxygen lyase activity//heme binding//mercury ion transmembrane transporter activity GO:0005835//GO:0016020 fatty acid synthase complex//membrane KOG1202 Animal-type fatty acid synthase and related proteins Cluster-8309.56397 BF_2 18.35 0.42 2113 73765582 AAZ85125.1 1069 1.5e-113 Down Syndrome adhesion molecule splice variant 3.12.3.1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS29 460 2.6e-44 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56401 BF_2 16.55 0.37 2176 642937652 XP_966876.3 559 2.1e-54 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N4W9 383 2.3e-35 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF02150//PF13465//PF00096//PF01096 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS) GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0008270//GO:0003676//GO:0046872//GO:0003899//GO:0003677 zinc ion binding//nucleic acid binding//metal ion binding//DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.56402 BF_2 44.36 1.05 2055 642937652 XP_966876.3 559 2.0e-54 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N4W9 383 2.1e-35 Zinc finger protein 808 OS=Homo sapiens GN=ZNF808 PE=2 SV=2 PF07776//PF00096//PF13465 Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.56405 BF_2 5.00 3.27 346 795494021 XP_011708975.1 158 1.1e-08 PREDICTED: mast/stem cell growth factor receptor Kit isoform X4 [Macaca nemestrina] 170014706 NG_007456.1 346 6.55674e-180 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P10721 158 4.4e-10 Mast/stem cell growth factor receptor Kit OS=Homo sapiens GN=KIT PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56406 BF_2 29.44 3.01 696 91080703 XP_975295.1 321 2.7e-27 PREDICTED: uncharacterized protein LOC664189 [Tribolium castaneum]>gi|270005858|gb|EFA02306.1| hypothetical protein TcasGA2_TC007972 [Tribolium castaneum] 462358939 APGK01029925.1 54 2.90918e-17 Dendroctonus ponderosae Seq01029935, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56407 BF_2 7.00 1.12 549 348563593 XP_003467591.1 296 1.7e-24 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Cavia porcellus] 383087749 NG_012113.2 549 0 Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), RefSeqGene (LRG_310) on chromosome 3 K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 P32871 288 5.9e-25 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Bos taurus GN=PIK3CA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56410 BF_2 27.00 1.35 1126 170321839 BAG14264.1 445 1.8e-41 modular serine protease zymogen [Tenebrio molitor] -- -- -- -- -- -- -- -- -- Q6DIV5 153 5.4e-09 Inactive serine protease PAMR1 OS=Xenopus tropicalis GN=pamr1 PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.56413 BF_2 177.84 1.58 5009 478253546 ENN73864.1 968 1.8e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.76116e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 9.7e-82 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF06814//PF01529 Peptidase family M50//Lung seven transmembrane receptor//DHHC palmitoyltransferase GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG2585 Uncharacterized conserved protein Cluster-8309.56419 BF_2 30.00 3.31 666 256682069 ACV07665.1 304 2.4e-25 serine protease VI [Aedes aegypti] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P35041 301 2.2e-26 Trypsin-7 OS=Anopheles gambiae GN=TRYP7 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.5642 BF_2 18.43 0.69 1407 642923081 XP_970728.2 443 3.9e-41 PREDICTED: aquaporin NIP1-2-like [Tribolium castaneum] -- -- -- -- -- K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q25074 367 1.0e-33 Aquaporin OS=Haematobia irritans exigua PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane KOG0223 Aquaporin (major intrinsic protein family) Cluster-8309.56420 BF_2 2.00 5.04 276 357630235 EHJ78501.1 139 1.4e-06 trypsin-like protein precursor [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.56421 BF_2 6.01 0.31 1089 270012506 EFA08954.1 534 8.5e-52 hypothetical protein TcasGA2_TC006661 [Tribolium castaneum] 768434472 XM_011560346.1 37 1.30741e-07 PREDICTED: Plutella xylostella atrial natriuretic peptide receptor 1 (LOC105389255), mRNA K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 P18293 380 2.5e-35 Atrial natriuretic peptide receptor 1 OS=Mus musculus GN=Npr1 PE=2 SV=2 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.56423 BF_2 392.89 106.51 441 642917566 XP_008191259.1 276 2.8e-22 PREDICTED: transmembrane protein 258-like [Tribolium castaneum]>gi|642939410|ref|XP_008193314.1| PREDICTED: transmembrane protein 258 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q76LT9 249 1.6e-20 Transmembrane protein 258 OS=Gallus gallus GN=TMEM258 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4452 Predicted membrane protein Cluster-8309.56426 BF_2 24.00 0.76 1609 91089321 XP_972187.1 1076 1.8e-114 PREDICTED: facilitated trehalose transporter Tret1 [Tribolium castaneum]>gi|270012512|gb|EFA08960.1| hypothetical protein TcasGA2_TC006667 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A9ZSY3 598 2.0e-60 Facilitated trehalose transporter Tret1 OS=Bombyx mori GN=Tret1 PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.56427 BF_2 38.85 0.75 2467 861641895 KMQ93718.1 1401 5.6e-152 serine threonine-protein kinase 36 [Lasius niger] -- -- -- -- -- K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 P23647 840 2.6e-88 Serine/threonine-protein kinase fused OS=Drosophila melanogaster GN=fu PE=1 SV=2 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0580 Serine/threonine protein kinase Cluster-8309.56428 BF_2 31.46 0.69 2205 861641895 KMQ93718.1 1267 1.7e-136 serine threonine-protein kinase 36 [Lasius niger] 817083926 XM_012409166.1 66 2.03457e-23 PREDICTED: Athalia rosae serine/threonine-protein kinase fused (LOC105690966), transcript variant X2, mRNA K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 P23647 867 1.7e-91 Serine/threonine-protein kinase fused OS=Drosophila melanogaster GN=fu PE=1 SV=2 PF07714//PF00069//PF06293//PF10598 Protein tyrosine kinase//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//RNA recognition motif of the spliceosomal PrP8 GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0003723//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//RNA binding//protein kinase activity GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.56432 BF_2 12.69 1.56 628 728418241 AIY68362.1 320 3.2e-27 esterase [Leptinotarsa decemlineata] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 Q8QZR3 238 4.2e-19 Pyrethroid hydrolase Ces2a OS=Mus musculus GN=Ces2a PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56433 BF_2 10.80 0.67 960 478263078 ENN81478.1 540 1.5e-52 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IN81 289 7.9e-25 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56435 BF_2 154.50 1.68 4130 478263078 ENN81478.1 1060 3.3e-112 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8IN81 289 3.4e-24 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00376//PF00196//PF00651//PF13411 MerR family regulatory protein//Bacterial regulatory proteins, luxR family//BTB/POZ domain//MerR HTH family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.56437 BF_2 4.00 0.64 548 91084819 XP_973299.1 230 7.6e-17 PREDICTED: protein abrupt [Tribolium castaneum]>gi|270008590|gb|EFA05038.1| hypothetical protein TcasGA2_TC015126 [Tribolium castaneum] 642925929 XM_968206.2 79 2.86057e-31 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q9W0K4 148 1.0e-08 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF10186//PF08802 Vacuolar sorting 38 and autophagy-related subunit 14//Cytochrome B6-F complex Fe-S subunit GO:0006118//GO:0010508//GO:0055114 obsolete electron transport//positive regulation of autophagy//oxidation-reduction process GO:0051537//GO:0009496 2 iron, 2 sulfur cluster binding//plastoquinol--plastocyanin reductase activity GO:0042651//GO:0009512 thylakoid membrane//cytochrome b6f complex -- -- Cluster-8309.56442 BF_2 1.00 1.70 292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56443 BF_2 26.00 2.34 751 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56450 BF_2 36.88 50.58 302 195121042 XP_002005030.1 171 2.9e-10 GI20245 [Drosophila mojavensis]>gi|193910098|gb|EDW08965.1| GI20245 [Drosophila mojavensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56453 BF_2 100.00 1.03 4346 326670210 XP_003199161.1 1945 8.2e-215 PREDICTED: uncharacterized protein K02A2.6-like [Danio rerio] -- -- -- -- -- -- -- -- -- P0CT36 758 1.5e-78 Transposon Tf2-3 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-3 PE=1 SV=1 PF00665//PF00098 Integrase core domain//Zinc knuckle GO:0015074 DNA integration GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.56457 BF_2 25.56 0.34 3410 10798899 AAG23133.1 1740 3.8e-191 alpha-amylase [Diabrotica virgifera virgifera] 153926498 AK283612.1 52 1.91681e-15 Gryllus bimaculatus mRNA, GBcontig30473 K01176 E3.2.1.1, amyA, malS alpha-amylase http://www.genome.jp/dbget-bin/www_bget?ko:K01176 P09107 1725 8.6e-191 Alpha-amylase (Fragment) OS=Tribolium castaneum PE=3 SV=2 PF02806//PF00128 Alpha amylase, C-terminal all-beta domain//Alpha amylase, catalytic domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0003824 cation binding//catalytic activity -- -- KOG2212 Alpha-amylase Cluster-8309.56458 BF_2 384.87 2.42 6930 270014766 EFA11214.1 3269 0.0e+00 hypothetical protein TcasGA2_TC005178 [Tribolium castaneum] 642911197 XM_008201346.1 101 2.25817e-42 PREDICTED: Tribolium castaneum solute carrier family 12 member 4 (LOC660690), transcript variant X2, mRNA K14427 SLC12A4_5_6, KCC solute carrier family 12 (potassium/chloride transporter), member 4/5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K14427 Q9UP95 2270 1.1e-253 Solute carrier family 12 member 4 OS=Homo sapiens GN=SLC12A4 PE=1 SV=2 PF05038//PF03522//PF00324//PF13520 Cytochrome Cytochrome b558 alpha-subunit//Solute carrier family 12//Amino acid permease//Amino acid permease GO:0055085//GO:0006865//GO:0006810//GO:0003333//GO:0006811 transmembrane transport//amino acid transport//transport//amino acid transmembrane transport//ion transport GO:0015171//GO:0005215//GO:0020037 amino acid transmembrane transporter activity//transporter activity//heme binding GO:0016020 membrane KOG2082 K+/Cl- cotransporter KCC1 and related transporters Cluster-8309.56465 BF_2 2.00 1.10 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56467 BF_2 4.00 3.25 331 -- -- -- -- -- 566156045 XM_002300723.2 99 1.26445e-42 Populus trichocarpa dihydroflavonol reductase family protein (POPTR_0002s03500g) mRNA, complete cds -- -- -- -- Q9XES5 370 1.1e-34 Bifunctional dihydroflavonol 4-reductase/flavanone 4-reductase OS=Malus domestica GN=DFR PE=1 SV=1 PF04069 Substrate binding domain of ABC-type glycine betaine transport system GO:0006810 transport GO:0005215 transporter activity -- -- -- -- Cluster-8309.56468 BF_2 70.92 1.25 2662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56470 BF_2 1.00 0.64 348 780086179 XP_011673431.1 166 1.3e-09 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q9GKW8 160 2.6e-10 Ankyrin repeat and death domain-containing protein 1A (Fragment) OS=Macaca fascicularis GN=ANKDD1A PE=2 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56475 BF_2 21.37 0.54 1933 91086011 XP_972761.1 2152 3.6e-239 PREDICTED: uncharacterized protein LOC661513 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08300 Hepatitis C virus non-structural 5a zinc finger domain -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.56476 BF_2 50.75 0.60 3833 564248485 XP_006263331.1 699 2.2e-70 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 660 3.0e-67 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF06467//PF07776//PF04858//PF01155//PF00130//PF00096//PF02176//PF01428//PF16622//PF02892//PF00412//PF13912//PF13465 MYM-type Zinc finger with FCS sequence motif//Zinc-finger associated domain (zf-AD)//TH1 protein//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc finger, C2H2 type//TRAF-type zinc finger//AN1-like Zinc finger//zinc-finger C2H2-type//BED zinc finger//LIM domain//C2H2-type zinc finger//Zinc-finger double domain GO:0006464//GO:0045892//GO:0035556 cellular protein modification process//negative regulation of transcription, DNA-templated//intracellular signal transduction GO:0003677//GO:0016151//GO:0008270//GO:0046872 DNA binding//nickel cation binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.56479 BF_2 24.60 0.35 3222 189235122 XP_001811652.1 2006 5.1e-222 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 422 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1600 2.5e-176 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF02724//PF03612//PF08496//PF04277//PF00856//PF01496 CDC45-like protein//Sorbitol phosphotransferase enzyme II N-terminus//Peptidase family S49 N-terminal//Oxaloacetate decarboxylase, gamma chain//SET domain//V-type ATPase 116kDa subunit family GO:0008643//GO:0006560//GO:0015991//GO:0006814//GO:0071436//GO:0006090//GO:0009401//GO:0015992//GO:0006525//GO:0006270 carbohydrate transport//proline metabolic process//ATP hydrolysis coupled proton transport//sodium ion transport//sodium ion export//pyruvate metabolic process//phosphoenolpyruvate-dependent sugar phosphotransferase system//proton transport//arginine metabolic process//DNA replication initiation GO:0008982//GO:0015081//GO:0005515//GO:0015078//GO:0003682//GO:0004252//GO:0008948 protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//sodium ion transmembrane transporter activity//protein binding//hydrogen ion transmembrane transporter activity//chromatin binding//serine-type endopeptidase activity//oxaloacetate decarboxylase activity GO:0016020//GO:0033179//GO:0000785//GO:0005886//GO:0009357//GO:0016021 membrane//proton-transporting V-type ATPase, V0 domain//chromatin//plasma membrane//protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//integral component of membrane KOG1079 Transcriptional repressor EZH1 Cluster-8309.56483 BF_2 7.11 0.49 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56484 BF_2 48.38 0.92 2495 826414794 XP_012522095.1 1394 3.7e-151 PREDICTED: calpain-B isoform X5 [Monomorium pharaonis] 805805104 XM_003705388.2 60 4.99264e-20 PREDICTED: Megachile rotundata calpain-A (LOC100882339), transcript variant X9, mRNA K08585 CAPNN calpain, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K08585 Q9VT65 1282 1.5e-139 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF00648//PF13202//PF12763//PF13833//PF13405//PF00036//PF13499 Calpain family cysteine protease//EF hand//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain//EF hand//EF-hand domain pair GO:0006508 proteolysis GO:0005509//GO:0004198//GO:0005515 calcium ion binding//calcium-dependent cysteine-type endopeptidase activity//protein binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.56485 BF_2 33.86 0.58 2724 826414810 XP_012522103.1 1099 6.5e-117 PREDICTED: calpain-B isoform X10 [Monomorium pharaonis] 329299079 NM_001160405.2 41 1.98943e-09 Apis mellifera calpain-B (Calpb), mRNA K03853 CAPN2 calpain-2 http://www.genome.jp/dbget-bin/www_bget?ko:K03853 Q9VT65 1031 2.0e-110 Calpain-B OS=Drosophila melanogaster GN=CalpB PE=1 SV=2 PF13405//PF00036//PF13833//PF13499//PF00648//PF13202 EF-hand domain//EF hand//EF-hand domain pair//EF-hand domain pair//Calpain family cysteine protease//EF hand GO:0006508 proteolysis GO:0004198//GO:0005509 calcium-dependent cysteine-type endopeptidase activity//calcium ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.56486 BF_2 2.00 0.52 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56487 BF_2 102.25 1.24 3730 642913362 XP_008195422.1 235 1.4e-16 PREDICTED: uncharacterized protein LOC103313584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56490 BF_2 39.19 0.94 2031 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56491 BF_2 15.02 0.37 1980 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56493 BF_2 35.29 0.45 3572 91084963 XP_971862.1 1094 3.2e-116 PREDICTED: GPI mannosyltransferase 4 [Tribolium castaneum]>gi|270009003|gb|EFA05451.1| hypothetical protein TcasGA2_TC015632 [Tribolium castaneum] -- -- -- -- -- K08098 PIGZ, SMP3 phosphatidylinositol glycan, class Z http://www.genome.jp/dbget-bin/www_bget?ko:K08098 Q8MT80 638 1.0e-64 GPI mannosyltransferase 4 OS=Drosophila melanogaster GN=CG45068 PE=2 SV=1 PF04428//PF03901 Choline kinase N terminus//Alg9-like mannosyltransferase family GO:0006506 GPI anchor biosynthetic process GO:0016773//GO:0016757 phosphotransferase activity, alcohol group as acceptor//transferase activity, transferring glycosyl groups GO:0031227 intrinsic component of endoplasmic reticulum membrane KOG4123 Putative alpha 1,2 mannosyltransferase Cluster-8309.56494 BF_2 123.96 2.17 2672 642931697 XP_008196692.1 1336 2.1e-144 PREDICTED: uncharacterized protein LOC657740 isoform X1 [Tribolium castaneum]>gi|270012781|gb|EFA09229.1| stem cell tumour protein [Tribolium castaneum] -- -- -- -- -- K02857 RHBDL1_2_3 rhomboid-related protein 1/2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K02857 P20350 547 2.7e-54 Protein rhomboid OS=Drosophila melanogaster GN=rho PE=1 SV=2 PF01694 Rhomboid family GO:0006508 proteolysis GO:0004252//GO:0005509 serine-type endopeptidase activity//calcium ion binding GO:0016021 integral component of membrane KOG2289 Rhomboid family proteins Cluster-8309.56496 BF_2 5.00 0.74 571 3915094 Q94572.1 917 1.7e-96 RecName: Full=Tubulin alpha-3 chain; AltName: Full=Alpha-III tubulin [Homarus americanus]>gi|1562539|gb|AAB08889.1| alpha-III tubulin [Homarus americanus] 871213160 XM_013091444.1 301 1.16505e-154 PREDICTED: Aplysia californica tubulin alpha-1A chain (LOC101845985), mRNA K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 Q94572 917 7.1e-98 Tubulin alpha-3 chain OS=Homarus americanus PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1376 Alpha tubulin Cluster-8309.56500 BF_2 14.91 0.47 1627 642915226 XP_971326.2 2054 7.1e-228 PREDICTED: TGF-beta receptor type-1 isoform X3 [Tribolium castaneum] 589944031 XM_006984651.1 98 2.42803e-41 PREDICTED: Peromyscus maniculatus bairdii activin A receptor, type IC (Acvr1c), transcript variant X2, mRNA K04674 TGFBR1, ALK5 TGF-beta receptor type-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04674 P36897 1475 4.0e-162 TGF-beta receptor type-1 OS=Homo sapiens GN=TGFBR1 PE=1 SV=1 PF08515//PF07714//PF01064//PF00069 Transforming growth factor beta type I GS-motif//Protein tyrosine kinase//Activin types I and II receptor domain//Protein kinase domain GO:0007178//GO:0016310//GO:0009069//GO:0006468 transmembrane receptor protein serine/threonine kinase signaling pathway//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0004675//GO:0004672//GO:0005524 transmembrane receptor protein serine/threonine kinase activity//protein kinase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.56501 BF_2 153.62 3.28 2247 642925984 XP_008194718.1 973 2.2e-102 PREDICTED: sugar phosphate exchanger 2 isoform X3 [Tribolium castaneum]>gi|642925986|ref|XP_008194719.1| PREDICTED: sugar phosphate exchanger 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- K13783 SLC37A1_2 MFS transporter, OPA family, solute carrier family 37 (glycerol-3-phosphate transporter), member 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K13783 Q8AVC3 591 1.8e-59 Sugar phosphate exchanger 2 OS=Xenopus laevis GN=slc37a2 PE=2 SV=1 PF02293//PF07690 AmiS/UreI family transporter//Major Facilitator Superfamily GO:0006810//GO:0055085 transport//transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG2533 Permease of the major facilitator superfamily Cluster-8309.56502 BF_2 25.89 1.22 1176 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56505 BF_2 21.00 0.56 1849 642910541 XP_008200256.1 2137 1.9e-237 PREDICTED: uncharacterized protein LOC660966 [Tribolium castaneum]>gi|270014411|gb|EFA10859.1| hypothetical protein TcasGA2_TC001636 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.56507 BF_2 42.59 1.25 1709 189164166 ACD77184.1 1560 1.4e-170 putative hepatocyte nuclear factor 4 nuclear hormone receptor [Callosobruchus maculatus] 189164165 EU545256.1 377 0 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 1240 7.5e-135 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00104//PF00105 Ligand-binding domain of nuclear hormone receptor//Zinc finger, C4 type (two domains) GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0043565//GO:0008270//GO:0003700 sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.56508 BF_2 4.07 0.61 564 642919019 XP_008191698.1 351 7.3e-31 PREDICTED: UPF0536 protein C12orf66-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08236 SRI (Set2 Rpb1 interacting) domain GO:0006355//GO:0006479//GO:0034968//GO:0006554 regulation of transcription, DNA-templated//protein methylation//histone lysine methylation//lysine catabolic process GO:0018024 histone-lysine N-methyltransferase activity GO:0005694 chromosome -- -- Cluster-8309.56513 BF_2 20.08 20.64 317 91079312 XP_967496.1 285 1.8e-23 PREDICTED: brachyurin [Tribolium castaneum]>gi|270004826|gb|EFA01274.1| serine protease P37 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P00768 165 6.2e-11 Chymotrypsin-2 OS=Vespa orientalis PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0008233//GO:0004252 peptidase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.56516 BF_2 4.06 1.12 438 817011235 AKF11871.1 456 3.8e-43 putative juvenile hormone epoxide hydrolase 2 [Leptinotarsa decemlineata] -- -- -- -- -- K10719 JHEH juvenile hormone epoxide hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K10719 Q8MZR6 329 8.2e-30 Juvenile hormone epoxide hydrolase 1 OS=Ctenocephalides felis GN=EH1 PE=1 SV=3 PF00969 Class II histocompatibility antigen, beta domain GO:0006955//GO:0019882 immune response//antigen processing and presentation -- -- GO:0016020//GO:0042613 membrane//MHC class II protein complex KOG2565 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) Cluster-8309.56517 BF_2 8.35 1.28 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56518 BF_2 20.67 0.50 2016 642940137 XP_008192016.1 1416 8.4e-154 PREDICTED: probable tyrosyl-DNA phosphodiesterase isoform X2 [Tribolium castaneum] -- -- -- -- -- K10862 TDP1 tyrosyl-DNA phosphodiesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10862 Q8BJ37 667 2.4e-68 Tyrosyl-DNA phosphodiesterase 1 OS=Mus musculus GN=Tdp1 PE=2 SV=2 PF06087 Tyrosyl-DNA phosphodiesterase GO:0006281 DNA repair GO:0008081 phosphoric diester hydrolase activity GO:0005634 nucleus KOG2031 Tyrosyl-DNA phosphodiesterase Cluster-8309.56522 BF_2 81.47 1.21 3108 189239121 XP_001815551.1 590 7.8e-58 PREDICTED: lysM and putative peptidoglycan-binding domain-containing protein 2 [Tribolium castaneum]>gi|270010334|gb|EFA06782.1| hypothetical protein TcasGA2_TC009718 [Tribolium castaneum] 766919473 XM_011505860.1 143 4.52099e-66 PREDICTED: Ceratosolen solmsi marchali transcription initiation factor IIA subunit 2 (LOC105367226), mRNA K03123 TFIIA2, GTF2A2, TOA2 transcription initiation factor TFIIA small subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03123 P52656 467 5.9e-45 Transcription initiation factor IIA subunit 2 OS=Drosophila melanogaster GN=TfIIA-S PE=1 SV=1 PF02268//PF02751 Transcription initiation factor IIA, gamma subunit, helical domain//Transcription initiation factor IIA, gamma subunit GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005672 transcription factor TFIIA complex KOG3463 Transcription initiation factor IIA, gamma subunit Cluster-8309.56523 BF_2 1.00 1.34 303 193690721 XP_001948117.1 173 1.7e-10 PREDICTED: UDP-glucuronosyltransferase 2B10-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- P36512 134 2.3e-07 UDP-glucuronosyltransferase 2B13 OS=Oryctolagus cuniculus GN=UGT2B13 PE=2 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.56524 BF_2 25.96 0.79 1667 642917912 XP_008191379.1 1037 6.1e-110 PREDICTED: UDP-glucuronosyltransferase 2B7 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q88168 528 2.7e-52 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF00201//PF00307//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Calponin homology (CH) domain//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758//GO:0005515 transferase activity, transferring hexosyl groups//protein binding -- -- -- -- Cluster-8309.56535 BF_2 325.70 1.50 9341 270007036 EFA03484.1 5689 0.0e+00 hypothetical protein TcasGA2_TC013483 [Tribolium castaneum] 642923390 XM_008195506.1 1301 0 PREDICTED: Tribolium castaneum protein still life, isoform SIF type 1 (LOC662876), mRNA K05731 TIAM1 T-lymphoma invasion and metastasis-inducing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05731 P91620 4612 0.0e+00 Protein still life, isoforms C/SIF type 2 OS=Drosophila melanogaster GN=sif PE=2 SV=2 PF00621//PF00595//PF02196//PF13180 RhoGEF domain//PDZ domain (Also known as DHR or GLGF)//Raf-like Ras-binding domain//PDZ domain GO:0043087//GO:0035023//GO:0007165 regulation of GTPase activity//regulation of Rho protein signal transduction//signal transduction GO:0005515//GO:0005089//GO:0005057 protein binding//Rho guanyl-nucleotide exchange factor activity//receptor signaling protein activity -- -- KOG3519 Invasion-inducing protein TIAM1/CDC24 and related RhoGEF GTPases Cluster-8309.56536 BF_2 63.83 1.55 2014 91089225 XP_968001.1 340 4.9e-29 PREDICTED: PRKR-interacting protein 1 homolog [Tribolium castaneum]>gi|270011471|gb|EFA07919.1| hypothetical protein TcasGA2_TC005495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6GNG8 221 1.3e-16 PRKR-interacting protein 1 homolog OS=Xenopus laevis GN=prkrip1 PE=2 SV=1 PF02862//PF04999 DDHD domain//Cell division protein FtsL GO:0051301//GO:0007049 cell division//cell cycle GO:0046872 metal ion binding GO:0016021 integral component of membrane KOG4055 Uncharacterized conserved protein Cluster-8309.56537 BF_2 40.22 0.54 3408 91094585 XP_969953.1 1523 5.5e-166 PREDICTED: parathyroid hormone/parathyroid hormone-related peptide receptor [Tribolium castaneum]>gi|270016404|gb|EFA12850.1| hypothetical protein TcasGA2_TC010267 [Tribolium castaneum]>gi|570932721|gb|AHF20217.1| parathyroid hormone receptor like 2 [Tribolium castaneum] -- -- -- -- -- K04585 PTHR1 parathyroid hormone receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04585 P25107 598 4.1e-60 Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Didelphis virginiana GN=PTH1R PE=2 SV=2 PF00002//PF00466//PF02793//PF00800 7 transmembrane receptor (Secretin family)//Ribosomal protein L10//Hormone receptor domain//Prephenate dehydratase GO:0007165//GO:0009094//GO:0007186//GO:0042254//GO:0000162//GO:0006571 signal transduction//L-phenylalanine biosynthetic process//G-protein coupled receptor signaling pathway//ribosome biogenesis//tryptophan biosynthetic process//tyrosine biosynthetic process GO:0004930//GO:0004664//GO:0004871 G-protein coupled receptor activity//prephenate dehydratase activity//signal transducer activity GO:0016021//GO:0016020//GO:0005622 integral component of membrane//membrane//intracellular -- -- Cluster-8309.56541 BF_2 4.00 4.51 312 -- -- -- -- -- 93116077 DQ490952.1 312 4.64776e-161 Zea mays subsp. mays genotype male-fertile NA mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56544 BF_2 3.00 0.34 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56545 BF_2 8.02 0.35 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56546 BF_2 40.31 0.39 4577 546674380 ERL85767.1 2461 1.3e-274 hypothetical protein D910_03182 [Dendroctonus ponderosae] 641673871 XM_001952487.3 196 2.3037e-95 PREDICTED: Acyrthosiphon pisum uncharacterized LOC100160518 (LOC100160518), partial mRNA -- -- -- -- Q29441 837 1.1e-87 Cyclic nucleotide-gated cation channel alpha-3 OS=Bos taurus GN=CNGA3 PE=2 SV=1 PF00520//PF03938 Ion transport protein//Outer membrane protein (OmpH-like) GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0051082//GO:0005216 unfolded protein binding//ion channel activity GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.56550 BF_2 395.01 11.38 1739 91084991 XP_972796.1 1236 5.4e-133 PREDICTED: serine palmitoyltransferase 1 [Tribolium castaneum]>gi|270009012|gb|EFA05460.1| hypothetical protein TcasGA2_TC015642 [Tribolium castaneum] -- -- -- -- -- K00654 SPT serine palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00654 P91079 707 4.8e-73 Serine palmitoyltransferase 1 OS=Caenorhabditis elegans GN=sptl-1 PE=3 SV=1 PF00155//PF01053 Aminotransferase class I and II//Cys/Met metabolism PLP-dependent enzyme GO:0009058 biosynthetic process GO:0030170 pyridoxal phosphate binding -- -- KOG1358 Serine palmitoyltransferase Cluster-8309.56551 BF_2 3.00 0.45 569 744514391 AJC97118.1 898 2.7e-94 Rab11A [Macrobrachium rosenbergii] 262400948 FJ774654.1 250 2.60296e-126 Scylla paramamosain RAB11a member RAS oncogene family mRNA, partial cds K07905 RAB11B Ras-related protein Rab-11B http://www.genome.jp/dbget-bin/www_bget?ko:K07905 P22129 818 2.1e-86 Ras-related protein Rab-11B OS=Diplobatis ommata PE=2 SV=1 PF01926//PF08477//PF00735//PF07728//PF02421//PF00025//PF00005//PF03193//PF04670//PF00071//PF10662 50S ribosome-binding GTPase//Ras of Complex, Roc, domain of DAPkinase//Septin//AAA domain (dynein-related subfamily)//Ferrous iron transport protein B//ADP-ribosylation factor family//ABC transporter//Protein of unknown function, DUF258//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation GO:0015684//GO:0007264//GO:0006576 ferrous iron transport//small GTPase mediated signal transduction//cellular biogenic amine metabolic process GO:0016887//GO:0005525//GO:0003924//GO:0015093//GO:0005524 ATPase activity//GTP binding//GTPase activity//ferrous iron transmembrane transporter activity//ATP binding GO:0016021 integral component of membrane KOG0087 GTPase Rab11/YPT3, small G protein superfamily Cluster-8309.56552 BF_2 192.00 5.63 1714 91082987 XP_974250.1 774 2.0e-79 PREDICTED: uncharacterized protein LOC663096 [Tribolium castaneum]>gi|270007031|gb|EFA03479.1| hypothetical protein TcasGA2_TC013478 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02735 Ku70/Ku80 beta-barrel domain GO:0006303 double-strand break repair via nonhomologous end joining GO:0003677 DNA binding -- -- -- -- Cluster-8309.5656 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56560 BF_2 257.72 2.67 4320 91092158 XP_967537.1 1880 2.8e-207 PREDICTED: steroid receptor seven-up, isoforms B/C [Tribolium castaneum]>gi|270015100|gb|EFA11548.1| seven up [Tribolium castaneum] 145228045 EF372598.1 535 0 Callosobruchus maculatus COUP-TF/Svp nuclear hormone receptor (Svp) mRNA, complete cds K08547 NR2F1, TFCOUP1 COUP transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08547 P16375 1629 1.5e-179 Steroid receptor seven-up, isoforms B/C OS=Drosophila melanogaster GN=svp PE=2 SV=1 PF14554//PF00105//PF02736//PF00104 VEGF heparin-binding domain//Zinc finger, C4 type (two domains)//Myosin N-terminal SH3-like domain//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355//GO:0007165//GO:0030522 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated//signal transduction//intracellular receptor signaling pathway GO:0043565//GO:0008270//GO:0008201//GO:0003700//GO:0005524//GO:0003774//GO:0046872//GO:0003707//GO:0004879 sequence-specific DNA binding//zinc ion binding//heparin binding//transcription factor activity, sequence-specific DNA binding//ATP binding//motor activity//metal ion binding//steroid hormone receptor activity//RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0016459//GO:0005634//GO:0005667 myosin complex//nucleus//transcription factor complex -- -- Cluster-8309.56564 BF_2 68.59 0.72 4255 642918699 XP_008191544.1 1540 7.4e-168 PREDICTED: protein sprint isoform X4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8MQW8 632 5.9e-64 Protein sprint OS=Drosophila melanogaster GN=spri PE=2 SV=3 PF15200 Keratinocyte differentiation-associated -- -- -- -- GO:0005576 extracellular region KOG2320 RAS effector RIN1 (contains VPS domain) Cluster-8309.56565 BF_2 5.00 11.07 281 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56569 BF_2 49.36 0.92 2531 642930226 XP_008196308.1 1549 4.0e-169 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 595 6.9e-60 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF01842//PF13291//PF13184 ACT domain//ACT domain//NusA-like KH domain GO:0008152 metabolic process GO:0016597//GO:0003723 amino acid binding//RNA binding -- -- KOG1250 Threonine/serine dehydratases Cluster-8309.56570 BF_2 69.59 1.07 3018 642930226 XP_008196308.1 1009 2.0e-106 PREDICTED: threo-3-hydroxyaspartate ammonia-lyase isoform X1 [Tribolium castaneum] -- -- -- -- -- K01754 E4.3.1.19, ilvA, tdcB threonine dehydratase http://www.genome.jp/dbget-bin/www_bget?ko:K01754 Q74FW6 354 7.2e-32 L-threonine ammonia-lyase OS=Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA) GN=tdcB PE=1 SV=1 PF01842 ACT domain GO:0008152 metabolic process GO:0016597 amino acid binding -- -- KOG1250 Threonine/serine dehydratases Cluster-8309.56572 BF_2 6.00 0.93 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56578 BF_2 3.00 1.34 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56584 BF_2 203.00 2.07 4386 478263044 ENN81444.1 2454 7.9e-274 hypothetical protein YQE_02137, partial [Dendroctonus ponderosae] -- -- -- -- -- K10902 RECQL5 ATP-dependent DNA helicase Q5 http://www.genome.jp/dbget-bin/www_bget?ko:K10902 Q8VID5 1195 3.2e-129 ATP-dependent DNA helicase Q5 OS=Mus musculus GN=Recql5 PE=2 SV=1 PF04851//PF08236//PF00270//PF00437 Type III restriction enzyme, res subunit//SRI (Set2 Rpb1 interacting) domain//DEAD/DEAH box helicase//Type II/IV secretion system protein GO:0034968//GO:0006810//GO:0006554//GO:0006355//GO:0006479 histone lysine methylation//transport//lysine catabolic process//regulation of transcription, DNA-templated//protein methylation GO:0005524//GO:0016787//GO:0003677//GO:0018024//GO:0003676 ATP binding//hydrolase activity//DNA binding//histone-lysine N-methyltransferase activity//nucleic acid binding GO:0005694 chromosome KOG0351 ATP-dependent DNA helicase Cluster-8309.56585 BF_2 38.60 1.30 1528 91077324 XP_974759.1 978 3.9e-103 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270001669|gb|EEZ98116.1| hypothetical protein TcasGA2_TC000534 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 Q5SPD7 522 1.2e-51 Pyrroline-5-carboxylate reductase 3 OS=Danio rerio GN=pycrl PE=2 SV=1 PF03446 NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006561//GO:0006525//GO:0006098//GO:0055114//GO:0019521 proline biosynthetic process//arginine metabolic process//pentose-phosphate shunt//oxidation-reduction process//D-gluconate metabolic process GO:0004735//GO:0004616//GO:0000166 pyrroline-5-carboxylate reductase activity//phosphogluconate dehydrogenase (decarboxylating) activity//nucleotide binding -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.56586 BF_2 12.00 0.80 916 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56589 BF_2 193.54 1.66 5176 642927107 XP_008195140.1 6577 0.0e+00 PREDICTED: sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 [Tribolium castaneum] 642927106 XM_008196918.1 476 0 PREDICTED: Tribolium castaneum sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (LOC660611), mRNA -- -- -- -- Q22328 982 1.9e-104 Protein lev-9 OS=Caenorhabditis elegans GN=lev-9 PE=1 SV=3 PF02793//PF00095 Hormone receptor domain//WAP-type (Whey Acidic Protein) 'four-disulfide core' GO:0007186 G-protein coupled receptor signaling pathway GO:0030414//GO:0004930 peptidase inhibitor activity//G-protein coupled receptor activity GO:0016020//GO:0005576 membrane//extracellular region KOG4297 C-type lectin Cluster-8309.56590 BF_2 12.06 0.75 956 546684145 ERL93850.1 502 3.8e-48 hypothetical protein D910_11136 [Dendroctonus ponderosae] -- -- -- -- -- K16469 CROCC rootletin http://www.genome.jp/dbget-bin/www_bget?ko:K16469 Q8CJ40 227 1.2e-17 Rootletin OS=Mus musculus GN=Crocc PE=1 SV=2 PF01496//PF05529//PF06810//PF07851//PF04977//PF00992//PF07352//PF02601//PF08702//PF04799//PF00005//PF06005//PF09730//PF04111//PF06156//PF01763//PF17082//PF00769//PF15384//PF06220//PF06160//PF10473 V-type ATPase 116kDa subunit family//B-cell receptor-associated protein 31-like//Phage minor structural protein GP20//TMPIT-like protein//Septum formation initiator//Troponin//Bacteriophage Mu Gam like protein//Exonuclease VII, large subunit//Fibrinogen alpha/beta chain family//fzo-like conserved region//ABC transporter//Protein of unknown function (DUF904)//Microtubule-associated protein Bicaudal-D//Autophagy protein Apg6//Protein of unknown function (DUF972)//Herpesvirus UL6 like//Spindle Pole Component 29//Ezrin/radixin/moesin family//PAXX, PAralog of XRCC4 and XLF, also called C9orf142//U1 zinc finger//Septation ring formation regulator, EzrA//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0030474//GO:0000921//GO:0042262//GO:0008053//GO:0030168//GO:0006303//GO:0015992//GO:0006260//GO:0015991//GO:0006308//GO:0000917//GO:0043093//GO:0051258//GO:0006914//GO:0006886//GO:0006810//GO:0007165//GO:0007049//GO:0006323 spindle pole body duplication//septin ring assembly//DNA protection//mitochondrial fusion//platelet activation//double-strand break repair via nonhomologous end joining//proton transport//DNA replication//ATP hydrolysis coupled proton transport//DNA catabolic process//barrier septum assembly//FtsZ-dependent cytokinesis//protein polymerization//autophagy//intracellular protein transport//transport//signal transduction//cell cycle//DNA packaging GO:0008092//GO:0030674//GO:0003924//GO:0008134//GO:0045502//GO:0005524//GO:0005200//GO:0005102//GO:0016887//GO:0008855//GO:0003690//GO:0042803//GO:0005198//GO:0008270//GO:0015078 cytoskeletal protein binding//protein binding, bridging//GTPase activity//transcription factor binding//dynein binding//ATP binding//structural constituent of cytoskeleton//receptor binding//ATPase activity//exodeoxyribonuclease VII activity//double-stranded DNA binding//protein homodimerization activity//structural molecule activity//zinc ion binding//hydrogen ion transmembrane transporter activity GO:0005667//GO:0030286//GO:0005861//GO:0005794//GO:0019898//GO:0005577//GO:0009318//GO:0005783//GO:0005856//GO:0033179//GO:0005741//GO:0005940//GO:0016021//GO:0005737//GO:0005823 transcription factor complex//dynein complex//troponin complex//Golgi apparatus//extrinsic component of membrane//fibrinogen complex//exodeoxyribonuclease VII complex//endoplasmic reticulum//cytoskeleton//proton-transporting V-type ATPase, V0 domain//mitochondrial outer membrane//septin ring//integral component of membrane//cytoplasm//central plaque of spindle pole body -- -- Cluster-8309.56594 BF_2 11.00 0.35 1589 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56595 BF_2 7.06 5.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56596 BF_2 496.72 5.19 4292 546674526 ERL85886.1 4701 0.0e+00 hypothetical protein D910_03301 [Dendroctonus ponderosae] -- -- -- -- -- K14312 NUP155, NUP170, NUP157 nuclear pore complex protein Nup155 http://www.genome.jp/dbget-bin/www_bget?ko:K14312 Q99P88 2301 1.8e-257 Nuclear pore complex protein Nup155 OS=Mus musculus GN=Nup155 PE=1 SV=1 PF04454//PF06433//PF05184 Encapsulating protein for peroxidase//Methylamine dehydrogenase heavy chain (MADH)//Saposin-like type B, region 1 GO:0006629//GO:0055114//GO:0042742//GO:0015947 lipid metabolic process//oxidation-reduction process//defense response to bacterium//methane metabolic process GO:0008233//GO:0030058 peptidase activity//amine dehydrogenase activity GO:0042597 periplasmic space KOG1900 Nuclear pore complex, Nup155 component (D Nup154, sc Nup157/Nup170) Cluster-8309.56604 BF_2 23.36 0.40 2719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15734 Migration and invasion-inhibitory GO:0010972//GO:0030336 negative regulation of G2/M transition of mitotic cell cycle//negative regulation of cell migration -- -- -- -- -- -- Cluster-8309.56606 BF_2 105.82 0.67 6921 642928264 XP_969418.2 1644 1.0e-179 PREDICTED: KAT8 regulatory NSL complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K18401 KANSL2 KAT8 regulatory NSL complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18401 Q2NL14 660 5.4e-67 KAT8 regulatory NSL complex subunit 2 OS=Bos taurus GN=KANSL2 PE=2 SV=1 PF11722 CCCH zinc finger in TRM13 protein -- -- GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.56608 BF_2 210.24 1.57 5898 189237665 XP_001812360.1 414 3.8e-37 PREDICTED: RNA-binding protein 34 [Tribolium castaneum]>gi|270007816|gb|EFA04264.1| hypothetical protein TcasGA2_TC014554 [Tribolium castaneum] -- -- -- -- -- K14837 NOP12 nucleolar protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14837 Q6CKV6 265 2.9e-21 Nucleolar protein 12 OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=NOP12 PE=3 SV=2 PF04258//PF00076//PF16367//PF07525 Signal peptide peptidase//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif//SOCS box GO:0035556 intracellular signal transduction GO:0004190//GO:0003676 aspartic-type endopeptidase activity//nucleic acid binding GO:0016021 integral component of membrane KOG0118 FOG: RRM domain Cluster-8309.56611 BF_2 120.31 1.12 4783 642911232 XP_008199678.1 2029 1.6e-224 PREDICTED: uncharacterized protein LOC661025 isoform X5 [Tribolium castaneum] 642911231 XM_008201456.1 94 1.21111e-38 PREDICTED: Tribolium castaneum nuclear protein MDM1 (LOC661025), transcript variant X6, mRNA -- -- -- -- Q5ZMW6 134 3.7e-06 Nuclear protein MDM1 OS=Gallus gallus GN=MDM1 PE=2 SV=1 PF15501 Nuclear protein MDM1 -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.56612 BF_2 16.38 0.31 2467 478260635 ENN80338.1 354 1.4e-30 hypothetical protein YQE_03330, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56614 BF_2 7.00 3.12 379 625194533 XP_007639696.1 348 1.1e-30 PREDICTED: hepatocyte growth factor receptor isoform X1 [Cricetulus griseus]>gi|625194535|ref|XP_007639697.1| PREDICTED: hepatocyte growth factor receptor isoform X1 [Cricetulus griseus]>gi|625194537|ref|XP_007639698.1| PREDICTED: hepatocyte growth factor receptor isoform X1 [Cricetulus griseus] 212720875 NG_008996.1 379 0 Homo sapiens MET proto-oncogene, receptor tyrosine kinase (MET), RefSeqGene (LRG_662) on chromosome 7 K05099 MET, HGFR proto-oncogene tyrosine-protein kinase Met http://www.genome.jp/dbget-bin/www_bget?ko:K05099 Q2QLA9 333 2.4e-30 Hepatocyte growth factor receptor OS=Equus caballus GN=MET PE=3 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- -- -- Cluster-8309.56626 BF_2 1.00 1.87 288 725563348 XP_010334997.1 293 2.0e-24 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC101029017 [Saimiri boliviensis boliviensis] 50657432 AC093029.4 192 2.16677e-94 Homo sapiens chromosome X clone XX-16186 map p11.4, complete sequence -- -- -- -- Q05481 161 1.6e-10 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56629 BF_2 6.00 0.67 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56630 BF_2 8.00 2.49 421 -- -- -- -- -- 239764707 GQ220323.1 356 0 Vitis vinifera strain PN40024 mitochondrion, partial genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56631 BF_2 5.00 0.84 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56643 BF_2 7.72 0.38 1133 270011728 EFA08176.1 138 7.3e-06 hypothetical protein TcasGA2_TC005803 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56648 BF_2 61.54 2.74 1227 91084687 XP_968830.1 341 2.3e-29 PREDICTED: myotubularin-related protein 3 [Tribolium castaneum]>gi|270008930|gb|EFA05378.1| hypothetical protein TcasGA2_TC015545 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02050 Flagellar FliJ protein GO:0071973//GO:0006935 bacterial-type flagellum-dependent cell motility//chemotaxis GO:0003774 motor activity GO:0009288//GO:0016020 bacterial-type flagellum//membrane -- -- Cluster-8309.56649 BF_2 15.41 0.35 2135 642938263 XP_008198135.1 1516 2.2e-165 PREDICTED: rho GTPase-activating protein 19 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6INE5 272 1.6e-22 Rho GTPase-activating protein 19 OS=Xenopus laevis GN=arhgap19 PE=2 SV=1 PF00620 RhoGAP domain GO:0007165 signal transduction -- -- -- -- -- -- Cluster-8309.56650 BF_2 16.20 1.00 967 546675442 ERL86630.1 393 1.7e-35 hypothetical protein D910_04037 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VVE2 293 2.7e-25 Protein rogdi OS=Drosophila melanogaster GN=rogdi PE=1 SV=2 PF05320 Poxvirus DNA-directed RNA polymerase 19 kDa subunit GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.56654 BF_2 250.86 2.59 4332 641783189 XP_008174001.1 762 1.2e-77 PREDICTED: zinc finger protein 850-like, partial [Chrysemys picta bellii] 795495644 XM_011710948.1 39 4.113e-08 PREDICTED: Macaca nemestrina zinc finger protein 713 (ZNF713), transcript variant X5, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ECI4 734 8.9e-76 Zinc finger protein 470 OS=Homo sapiens GN=ZNF470 PE=2 SV=3 PF13912//PF07776//PF08054//PF00096//PF02178//PF13465 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Leucine operon leader peptide//Zinc finger, C2H2 type//AT hook motif//Zinc-finger double domain GO:0009098 leucine biosynthetic process GO:0003677//GO:0008270//GO:0046872 DNA binding//zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.56657 BF_2 105.25 0.84 5523 189239721 XP_967180.2 687 7.8e-69 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 377 2.8e-34 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF00320//PF04921 GATA zinc finger//XAP5, circadian clock regulator GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.56667 BF_2 8.09 0.58 872 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56670 BF_2 17.00 0.46 1838 546685412 ERL94925.1 567 2.1e-55 hypothetical protein D910_12197 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05478 Prominin -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.56675 BF_2 88.29 2.55 1737 546671410 ERL83733.1 739 2.3e-75 hypothetical protein D910_00946 [Dendroctonus ponderosae]>gi|546671482|gb|ERL83777.1| hypothetical protein D910_01015 [Dendroctonus ponderosae]>gi|546671488|gb|ERL83781.1| hypothetical protein D910_01019 [Dendroctonus ponderosae] -- -- -- -- -- K10990 RMI1, BRAP75 RecQ-mediated genome instability protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10990 Q7ZVM9 410 1.3e-38 RecQ-mediated genome instability protein 1 OS=Danio rerio GN=rmi1 PE=2 SV=1 PF16099 Recq-mediated genome instability protein 1, C-terminal OB-fold -- -- GO:0000166 nucleotide binding -- -- KOG3683 Uncharacterized conserved protein Cluster-8309.56677 BF_2 22.48 1.83 802 282158097 NP_001164092.1 453 1.5e-42 quaking related [Tribolium castaneum] -- -- -- -- -- K14942 KHDRBS3, SLM2 KH domain-containing, RNA-binding, signal transduction-associated protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14942 Q0VFL3 135 4.8e-07 KH domain-containing, RNA-binding, signal transduction-associated protein 2 OS=Xenopus tropicalis GN=khdrbs2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56680 BF_2 11.00 4.29 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56681 BF_2 2.00 0.66 413 91083233 XP_973728.1 259 2.5e-20 PREDICTED: dolichyldiphosphatase 1 [Tribolium castaneum]>gi|270006958|gb|EFA03406.1| hypothetical protein TcasGA2_TC013393 [Tribolium castaneum] -- -- -- -- -- K07252 E3.6.1.43 dolichyldiphosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K07252 B2KI79 132 5.4e-07 Dolichyldiphosphatase 1 OS=Rhinolophus ferrumequinum GN=DOLPP1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56683 BF_2 623.64 3.98 6844 642924707 XP_008194406.1 3678 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 isoform X2 [Tribolium castaneum] 642924706 XM_008196184.1 283 1.49645e-143 PREDICTED: Tribolium castaneum inactive dipeptidyl peptidase 10 (LOC663947), transcript variant X2, mRNA -- -- -- -- Q8N608 997 4.5e-106 Inactive dipeptidyl peptidase 10 OS=Homo sapiens GN=DPP10 PE=1 SV=2 PF00326//PF00930 Prolyl oligopeptidase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region GO:0006508 proteolysis GO:0008236 serine-type peptidase activity -- -- KOG2100 Dipeptidyl aminopeptidase Cluster-8309.56684 BF_2 1.00 0.37 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56689 BF_2 147.51 1.65 4031 642931800 XP_008196735.1 1800 5.0e-198 PREDICTED: probable tRNA (guanine(26)-N(2))-dimethyltransferase [Tribolium castaneum] 805826840 XM_012297893.1 36 1.77952e-06 PREDICTED: Megachile rotundata probable tRNA (guanine(26)-N(2))-dimethyltransferase (LOC105664233), mRNA K00555 TRMT1, trm1 tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00555 Q9VK89 1491 1.4e-163 Probable tRNA (guanine(26)-N(2))-dimethyltransferase OS=Drosophila melanogaster GN=CG6388 PE=2 SV=1 PF05175//PF03602//PF05958//PF02005 Methyltransferase small domain//Conserved hypothetical protein 95//tRNA (Uracil-5-)-methyltransferase//N2,N2-dimethylguanosine tRNA methyltransferase GO:0009451//GO:0006396//GO:0008033//GO:0031167 RNA modification//RNA processing//tRNA processing//rRNA methylation GO:0004809//GO:0008168//GO:0003723//GO:0008173 tRNA (guanine-N2-)-methyltransferase activity//methyltransferase activity//RNA binding//RNA methyltransferase activity -- -- KOG1253 tRNA methyltransferase Cluster-8309.56698 BF_2 1.00 0.34 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56703 BF_2 6.00 4.09 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56704 BF_2 359.97 7.64 2258 642923111 XP_008193614.1 2166 1.0e-240 PREDICTED: dnaJ homolog subfamily C member 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- K09531 DNAJC11 DnaJ homolog subfamily C member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K09531 Q5U458 1212 1.7e-131 DnaJ homolog subfamily C member 11 OS=Mus musculus GN=Dnajc11 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0718 Molecular chaperone (DnaJ superfamily) Cluster-8309.56706 BF_2 26.81 1.13 1281 91082061 XP_972013.1 763 2.8e-78 PREDICTED: nucleoporin NUP53 [Tribolium castaneum]>gi|270007411|gb|EFA03859.1| hypothetical protein TcasGA2_TC013975 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFH5 259 3.2e-21 Nucleoporin NUP53 OS=Homo sapiens GN=NUP35 PE=1 SV=1 PF02458 Transferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- KOG4285 Mitotic phosphoprotein Cluster-8309.56707 BF_2 31.55 0.65 2332 642936329 XP_008198398.1 1296 8.0e-140 PREDICTED: hemicentin-2-like isoform X2 [Tribolium castaneum] 642936328 XM_008200176.1 353 0 PREDICTED: Tribolium castaneum hemicentin-2-like (LOC657829), transcript variant X2, mRNA -- -- -- -- Q62718 140 3.6e-07 Neurotrimin OS=Rattus norvegicus GN=Ntm PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.56709 BF_2 34.69 2.63 838 91076370 XP_967715.1 482 7.0e-46 PREDICTED: ras-related protein Rab-27A [Tribolium castaneum]>gi|270002552|gb|EEZ98999.1| hypothetical protein TcasGA2_TC004860 [Tribolium castaneum] -- -- -- -- -- K07885 RAB27A Ras-related protein Rab-27A http://www.genome.jp/dbget-bin/www_bget?ko:K07885 Q4LE85 296 1.1e-25 Ras-related protein Rab-27A OS=Sus scrofa GN=RAB27A PE=2 SV=1 PF08477//PF01926//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Ras family GO:0007264//GO:0015031 small GTPase mediated signal transduction//protein transport GO:0005525 GTP binding -- -- KOG0081 GTPase Rab27, small G protein superfamily Cluster-8309.56712 BF_2 388.35 5.83 3076 642937115 XP_008198698.1 1875 7.6e-207 PREDICTED: uncharacterized protein LOC103314418 [Tribolium castaneum]>gi|270000875|gb|EEZ97322.1| hypothetical protein TcasGA2_TC011133 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00004//PF07088//PF00580 ATPase family associated with various cellular activities (AAA)//GvpD gas vesicle protein//UvrD/REP helicase N-terminal domain -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.56718 BF_2 101.54 1.73 2745 91082057 XP_971798.1 1924 1.4e-212 PREDICTED: mitochondrial chaperone BCS1 [Tribolium castaneum]>gi|270007281|gb|EFA03729.1| hypothetical protein TcasGA2_TC013838 [Tribolium castaneum] 815794844 XM_012362642.1 161 3.93076e-76 PREDICTED: Linepithema humile mitochondrial chaperone BCS1 (LOC105669594), mRNA K08900 BCS1 mitochondrial chaperone BCS1 http://www.genome.jp/dbget-bin/www_bget?ko:K08900 Q7ZV60 1367 2.3e-149 Mitochondrial chaperone BCS1 OS=Danio rerio GN=bcs1l PE=2 SV=2 PF00004//PF00910//PF06431//PF07728//PF00005 ATPase family associated with various cellular activities (AAA)//RNA helicase//Polyomavirus large T antigen C-terminus//AAA domain (dynein-related subfamily)//ABC transporter GO:0006260 DNA replication GO:0016887//GO:0003677//GO:0003723//GO:0005524//GO:0003724//GO:0017111 ATPase activity//DNA binding//RNA binding//ATP binding//RNA helicase activity//nucleoside-triphosphatase activity -- -- KOG0743 AAA+-type ATPase Cluster-8309.56720 BF_2 49.87 4.93 710 478257530 ENN77685.1 853 5.7e-89 hypothetical protein YQE_05835, partial [Dendroctonus ponderosae]>gi|546677864|gb|ERL88616.1| hypothetical protein D910_06001 [Dendroctonus ponderosae] 734646087 XM_010753864.1 176 4.50229e-85 PREDICTED: Larimichthys crocea protein phosphatase 2, regulatory subunit B', delta (ppp2r5d), partial mRNA K11584 PPP2R5 serine/threonine-protein phosphatase 2A regulatory subunit B' http://www.genome.jp/dbget-bin/www_bget?ko:K11584 Q14738 805 8.6e-85 Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform OS=Homo sapiens GN=PPP2R5D PE=1 SV=1 PF01603 Protein phosphatase 2A regulatory B subunit (B56 family) GO:0007165 signal transduction GO:0008601 protein phosphatase type 2A regulator activity GO:0000159 protein phosphatase type 2A complex KOG2085 Serine/threonine protein phosphatase 2A, regulatory subunit Cluster-8309.56722 BF_2 212.71 11.17 1084 642926763 XP_008195004.1 273 1.5e-21 PREDICTED: dolichol-phosphate mannosyltransferase subunit 3 [Tribolium castaneum]>gi|270008398|gb|EFA04846.1| hypothetical protein TcasGA2_TC014898 [Tribolium castaneum] -- -- -- -- -- K09659 DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 http://www.genome.jp/dbget-bin/www_bget?ko:K09659 Q9P2X0 166 1.6e-10 Dolichol-phosphate mannosyltransferase subunit 3 OS=Homo sapiens GN=DPM3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56732 BF_2 12.00 0.43 1461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00317 Ribonucleotide reductase, all-alpha domain GO:0055114//GO:0006260//GO:0006206//GO:0006144//GO:0009186 oxidation-reduction process//DNA replication//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process//deoxyribonucleoside diphosphate metabolic process GO:0004748//GO:0005524 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor//ATP binding GO:0005971 ribonucleoside-diphosphate reductase complex -- -- Cluster-8309.56733 BF_2 60.44 0.78 3548 641647749 XP_008179485.1 964 3.8e-101 PREDICTED: uncharacterized protein LOC103308217 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- B0BN95 130 8.0e-06 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 PF04928//PF03776//PF04827//PF01609 Poly(A) polymerase central domain//Septum formation topological specificity factor MinE//Plant transposon protein//Transposase DDE domain GO:0032955//GO:0051301//GO:0006313//GO:0043631 regulation of barrier septum assembly//cell division//transposition, DNA-mediated//RNA polyadenylation GO:0004803//GO:0016788//GO:0004652//GO:0003677 transposase activity//hydrolase activity, acting on ester bonds//polynucleotide adenylyltransferase activity//DNA binding -- -- -- -- Cluster-8309.56734 BF_2 8.14 0.50 972 642918043 XP_008198992.1 162 1.0e-08 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56735 BF_2 16.54 0.41 1987 576249490 AHH29251.1 1416 8.2e-154 Inebriated-like protein [Leptinotarsa decemlineata] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 1077 6.9e-116 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF13520//PF01384//PF00209 Amino acid permease//Phosphate transporter family//Sodium:neurotransmitter symporter family GO:0006865//GO:0006836//GO:0006817//GO:0006812//GO:0003333 amino acid transport//neurotransmitter transport//phosphate ion transport//cation transport//amino acid transmembrane transport GO:0015171//GO:0005328//GO:0005315 amino acid transmembrane transporter activity//neurotransmitter:sodium symporter activity//inorganic phosphate transmembrane transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.56736 BF_2 2.00 1.26 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56749 BF_2 15.40 1.45 731 293345785 XP_002726116.1 1164 5.0e-125 PREDICTED: 60S ribosomal protein L8 [Rattus norvegicus] 402744011 NM_001134038.2 718 0 Pongo abelii ribosomal protein L8 (RPL8), mRNA K02938 RP-L8e, RPL8 large subunit ribosomal protein L8e http://www.genome.jp/dbget-bin/www_bget?ko:K02938 P62917 1170 4.2e-127 60S ribosomal protein L8 OS=Homo sapiens GN=RPL8 PE=1 SV=2 PF00181//PF03947 Ribosomal Proteins L2, RNA binding domain//Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG2309 60s ribosomal protein L2/L8 Cluster-8309.56759 BF_2 17.00 1.15 905 795574939 XP_011722205.1 393 1.6e-35 PREDICTED: smoothened homolog isoform X1 [Macaca nemestrina] 11386323 AC083866.2 902 0 AC083866 Homo sapiens chromosome 7 clone RP11-702D16, complete sequence K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 Q99835 393 6.5e-37 Smoothened homolog OS=Homo sapiens GN=SMO PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56764 BF_2 6.78 0.41 972 270014145 EFA10593.1 276 6.2e-22 hypothetical protein TcasGA2_TC012853 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9WTR0 143 6.8e-08 Matrix metalloproteinase-16 OS=Mus musculus GN=Mmp16 PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56770 BF_2 28.41 0.63 2179 801399331 XP_012060168.1 159 5.2e-08 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56771 BF_2 45.26 1.01 2159 801399331 XP_012060168.1 159 5.1e-08 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08686 PLAC (protease and lacunin) domain -- -- GO:0008233 peptidase activity -- -- -- -- Cluster-8309.56774 BF_2 27.34 0.60 2179 297262435 XP_002798639.1 1782 3.3e-196 PREDICTED: keratin, type II cytoskeletal 6A-like isoform 1 [Macaca mulatta] 158261512 AK290245.1 1506 0 Homo sapiens cDNA FLJ78504 complete cds, highly similar to Homo sapiens keratin 6A (KRT6A), mRNA K07605 KRT2 type II keratin, basic http://www.genome.jp/dbget-bin/www_bget?ko:K07605 Q9Z331 1702 2.6e-188 Keratin, type II cytoskeletal 6B OS=Mus musculus GN=Krt6b PE=1 SV=3 PF08651//PF04111//PF07926//PF07464//PF10473//PF08074//PF00038//PF08702//PF04513 DASH complex subunit Duo1//Autophagy protein Apg6//TPR/MLP1/MLP2-like protein//Apolipophorin-III precursor (apoLp-III)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//CHDCT2 (NUC038) domain//Intermediate filament protein//Fibrinogen alpha/beta chain family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0030168//GO:0006869//GO:0006355//GO:0007067//GO:0006606//GO:0006914//GO:0051258//GO:0007165 platelet activation//lipid transport//regulation of transcription, DNA-templated//mitotic nuclear division//protein import into nucleus//autophagy//protein polymerization//signal transduction GO:0030674//GO:0042803//GO:0008289//GO:0003677//GO:0016818//GO:0008270//GO:0005102//GO:0005198//GO:0045502//GO:0008134//GO:0005524 protein binding, bridging//protein homodimerization activity//lipid binding//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//receptor binding//structural molecule activity//dynein binding//transcription factor binding//ATP binding GO:0005576//GO:0005667//GO:0019031//GO:0005634//GO:0072686//GO:0030286//GO:0005577//GO:0042729//GO:0005882//GO:0019028 extracellular region//transcription factor complex//viral envelope//nucleus//mitotic spindle//dynein complex//fibrinogen complex//DASH complex//intermediate filament//viral capsid -- -- Cluster-8309.56777 BF_2 1.00 3.52 264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56778 BF_2 10.73 0.85 813 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56781 BF_2 348.93 6.04 2705 642922702 XP_008193287.1 1703 5.9e-187 PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922704|ref|XP_008193288.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922706|ref|XP_008193289.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum]>gi|642922708|ref|XP_008193290.1| PREDICTED: sodium-coupled monocarboxylate transporter 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N695 750 7.8e-78 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF00474 Sodium:solute symporter family GO:0006810//GO:0055085 transport//transmembrane transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.56782 BF_2 6.73 0.35 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02891 MIZ/SP-RING zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.56783 BF_2 15.06 0.40 1862 478263026 ENN81426.1 141 5.4e-06 hypothetical protein YQE_02120, partial [Dendroctonus ponderosae]>gi|546686068|gb|ERL95468.1| hypothetical protein D910_12730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56786 BF_2 3.23 0.31 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56787 BF_2 20.66 0.73 1478 189235566 XP_970111.2 987 3.4e-104 PREDICTED: sphingosine kinase 2 [Tribolium castaneum]>gi|270004362|gb|EFA00810.1| hypothetical protein TcasGA2_TC003697 [Tribolium castaneum] -- -- -- -- -- K04718 SPHK sphingosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K04718 Q9JIA7 196 7.4e-14 Sphingosine kinase 2 OS=Mus musculus GN=Sphk2 PE=1 SV=2 PF00781 Diacylglycerol kinase catalytic domain GO:0007205//GO:0009395//GO:0046486 protein kinase C-activating G-protein coupled receptor signaling pathway//phospholipid catabolic process//glycerolipid metabolic process GO:0004143//GO:0016301 diacylglycerol kinase activity//kinase activity -- -- KOG1116 Sphingosine kinase, involved in sphingolipid metabolism Cluster-8309.56791 BF_2 139.14 5.89 1275 332373512 AEE61897.1 1119 1.5e-119 unknown [Dendroctonus ponderosae]>gi|478261742|gb|ENN80889.1| hypothetical protein YQE_02678, partial [Dendroctonus ponderosae]>gi|546674326|gb|ERL85730.1| hypothetical protein D910_03145 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 Q9VKH6 888 3.6e-94 Lysosomal thioesterase PPT2 homolog OS=Drosophila melanogaster GN=Ppt2 PE=2 SV=1 PF01674//PF02089 Lipase (class 2)//Palmitoyl protein thioesterase -- -- GO:0098599//GO:0016787 palmitoyl hydrolase activity//hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.56795 BF_2 31.72 0.90 1764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14144//PF00220 Seed dormancy control//Neurohypophysial hormones, N-terminal Domain GO:0007218//GO:0006351 neuropeptide signaling pathway//transcription, DNA-templated GO:0043565//GO:0005185 sequence-specific DNA binding//neurohypophyseal hormone activity GO:0005576 extracellular region -- -- Cluster-8309.5680 BF_2 1.00 0.80 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56804 BF_2 58.00 0.92 2937 642915284 XP_008190555.1 1571 1.3e-171 PREDICTED: DNA-binding protein D-ETS-3 isoform X1 [Tribolium castaneum] 642915285 XM_967896.3 282 2.29449e-143 PREDICTED: Tribolium castaneum DNA-binding protein D-ETS-3 (LOC661753), transcript variant X2, mRNA K09436 FLI1 friend leukemia integration 1 transcription factor http://www.genome.jp/dbget-bin/www_bget?ko:K09436 P29774 881 5.5e-93 DNA-binding protein D-ETS-3 OS=Drosophila melanogaster GN=Ets65A PE=2 SV=3 PF00178//PF00447 Ets-domain//HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG3806 Predicted transcription factor Cluster-8309.56806 BF_2 69.35 1.04 3077 91087699 XP_974256.1 900 8.7e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 6.0e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.56807 BF_2 16.35 0.45 1820 91087699 XP_974256.1 900 5.1e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 3.5e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.56811 BF_2 45.42 0.82 2616 270002150 EEZ98597.1 1410 5.4e-153 hypothetical protein TcasGA2_TC001116 [Tribolium castaneum] -- -- -- -- -- K12373 HEXA_B hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K12373 Q8WSF3 955 1.3e-101 Probable beta-hexosaminidase fdl OS=Drosophila melanogaster GN=fdl PE=1 SV=1 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG2499 Beta-N-acetylhexosaminidase Cluster-8309.56813 BF_2 55.68 0.60 4158 642939403 XP_008193263.1 1963 6.4e-217 PREDICTED: protein FAM135A [Tribolium castaneum]>gi|270016463|gb|EFA12909.1| hypothetical protein TcasGA2_TC006979 [Tribolium castaneum] 642939402 XM_008195041.1 369 0 PREDICTED: Tribolium castaneum protein FAM135A (LOC661082), mRNA -- -- -- -- Q5RA75 1083 2.9e-116 Protein FAM135A OS=Pongo abelii GN=FAM135A PE=2 SV=1 PF07819 PGAP1-like protein GO:0006505//GO:0006886 GPI anchor metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2205 Uncharacterized conserved protein Cluster-8309.56819 BF_2 8.00 0.40 1132 270015830 EFA12278.1 385 1.7e-34 hypothetical protein TcasGA2_TC005263 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02668 Taurine catabolism dioxygenase TauD, TfdA family GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.56821 BF_2 71.11 2.96 1292 546681611 ERL91675.1 1223 1.3e-131 hypothetical protein D910_09003 [Dendroctonus ponderosae] -- -- -- -- -- K03143 TFIIH3, GTF2H3, TFB4 transcription initiation factor TFIIH subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03143 Q561R7 745 1.4e-77 General transcription factor IIH subunit 3 OS=Rattus norvegicus GN=Gtf2h3 PE=2 SV=1 PF03850//PF07809 Transcription factor Tfb4//RTP801 C-terminal region GO:0009968//GO:0006355//GO:0006289 negative regulation of signal transduction//regulation of transcription, DNA-templated//nucleotide-excision repair -- -- GO:0000439//GO:0005737 core TFIIH complex//cytoplasm KOG2487 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB4 Cluster-8309.56822 BF_2 111.04 2.86 1910 642940135 XP_008191977.1 2067 2.6e-229 PREDICTED: probable tyrosyl-DNA phosphodiesterase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10862 TDP1 tyrosyl-DNA phosphodiesterase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10862 Q9VQM4 913 6.9e-97 Probable tyrosyl-DNA phosphodiesterase OS=Drosophila melanogaster GN=gkt PE=2 SV=1 PF06087 Tyrosyl-DNA phosphodiesterase GO:0006281 DNA repair GO:0008081 phosphoric diester hydrolase activity GO:0005634 nucleus KOG2031 Tyrosyl-DNA phosphodiesterase Cluster-8309.56826 BF_2 14.11 0.37 1882 270015871 EFA12319.1 1171 2.0e-125 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 P08487 714 8.1e-74 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Bos taurus GN=PLCG1 PE=1 SV=1 PF00387//PF00168 Phosphatidylinositol-specific phospholipase C, Y domain//C2 domain GO:0046339//GO:0007165//GO:0009395//GO:0035556//GO:0006629 diacylglycerol metabolic process//signal transduction//phospholipid catabolic process//intracellular signal transduction//lipid metabolic process GO:0004435//GO:0005515 phosphatidylinositol phospholipase C activity//protein binding -- -- KOG1264 Phospholipase C Cluster-8309.56827 BF_2 14.83 1.06 875 478258345 ENN78464.1 712 1.6e-72 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] 462363670 APGK01028279.1 38 2.89774e-08 Dendroctonus ponderosae Seq01028289, whole genome shotgun sequence K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 468 1.3e-45 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00664//PF03193//PF00005 ABC transporter transmembrane region//Protein of unknown function, DUF258//ABC transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0003924//GO:0005525//GO:0016887//GO:0042626 ATP binding//GTPase activity//GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.56828 BF_2 111.75 2.55 2123 478258345 ENN78464.1 1166 8.6e-125 hypothetical protein YQE_05102, partial [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 763 1.9e-79 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304//PF00664 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.56831 BF_2 17.10 0.64 1399 270006563 EFA03011.1 577 1.1e-56 hypothetical protein TcasGA2_TC010434 [Tribolium castaneum] 462363670 APGK01028279.1 38 4.69831e-08 Dendroctonus ponderosae Seq01028289, whole genome shotgun sequence -- -- -- -- P91660 306 1.2e-26 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF00664//PF02723 ABC transporter//Protein of unknown function, DUF258//ABC transporter transmembrane region//Non-structural protein NS3/Small envelope protein E GO:0055085//GO:0006810 transmembrane transport//transport GO:0005525//GO:0016887//GO:0042626//GO:0005524//GO:0003924 GTP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances//ATP binding//GTPase activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.56832 BF_2 7.35 0.42 1025 546677066 ERL87975.1 717 4.8e-73 hypothetical protein D910_05363 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 560 3.2e-56 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56833 BF_2 37.54 0.64 2735 642913582 XP_008201072.1 1731 3.4e-190 PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein phosphatase non-receptor type 21 [Tribolium castaneum] -- -- -- -- -- K18025 PTPN14_21 tyrosine-protein phosphatase non-receptor type 14/21 http://www.genome.jp/dbget-bin/www_bget?ko:K18025 Q15678 648 5.3e-66 Tyrosine-protein phosphatase non-receptor type 14 OS=Homo sapiens GN=PTPN14 PE=1 SV=2 PF00102//PF00782 Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0008138//GO:0004725 protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.56837 BF_2 27.73 0.63 2134 270012820 EFA09268.1 813 7.4e-84 neuropeptide-like precursor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0W6 194 1.8e-13 Neuropeptide-like 1 OS=Drosophila melanogaster GN=Nplp1 PE=1 SV=2 PF04120 Low affinity iron permease GO:0055085 transmembrane transport -- -- -- -- -- -- Cluster-8309.56842 BF_2 13.08 0.36 1817 637369105 XP_008121693.1 548 3.4e-53 PREDICTED: oocyte zinc finger protein XlCOF6-like isoform X2 [Anolis carolinensis] 533131911 XM_005380929.1 41 1.3193e-09 PREDICTED: Chinchilla lanigera zinc finger protein 133 (Znf133), transcript variant X9, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6ZMW2 517 5.5e-51 Zinc finger protein 782 OS=Homo sapiens GN=ZNF782 PE=2 SV=1 PF13912//PF16866//PF05191//PF01780//PF00096//PF13465 C2H2-type zinc finger//PHD-finger//Adenylate kinase, active site lid//Ribosomal L37ae protein family//Zinc finger, C2H2 type//Zinc-finger double domain GO:0042254//GO:0006144//GO:0046034//GO:0006412 ribosome biogenesis//purine nucleobase metabolic process//ATP metabolic process//translation GO:0003735//GO:0004017//GO:0046872//GO:0005515 structural constituent of ribosome//adenylate kinase activity//metal ion binding//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.56847 BF_2 4.00 1.26 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56849 BF_2 26.45 0.81 1659 642923261 XP_008193681.1 1290 2.8e-139 PREDICTED: T-cell activation inhibitor, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 422 5.2e-40 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56853 BF_2 2.00 0.35 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56855 BF_2 44.61 1.08 2023 642936688 XP_008198537.1 382 6.7e-34 PREDICTED: uncharacterized protein LOC655388 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56856 BF_2 14.65 0.39 1841 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0009523//GO:0009539//GO:0016020 photosystem II//photosystem II reaction center//membrane -- -- Cluster-8309.56862 BF_2 35.73 0.94 1875 861627332 KMQ89049.1 196 2.3e-12 hypothetical protein RF55_11358 [Lasius niger] -- -- -- -- -- -- -- -- -- P0CT36 128 7.2e-06 Transposon Tf2-3 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56865 BF_2 194.31 2.03 4289 478263078 ENN81478.1 1060 3.4e-112 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] 642925929 XM_968206.2 108 1.7902e-46 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q8IN81 289 3.5e-24 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF13411//PF00651//PF00196//PF00376 MerR HTH family regulatory protein//BTB/POZ domain//Bacterial regulatory proteins, luxR family//MerR family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005515 DNA binding//protein binding -- -- -- -- Cluster-8309.56866 BF_2 49.51 0.52 4277 478263078 ENN81478.1 1060 3.4e-112 hypothetical protein YQE_02170, partial [Dendroctonus ponderosae]>gi|546682120|gb|ERL92101.1| hypothetical protein D910_09422 [Dendroctonus ponderosae] 642925929 XM_968206.2 108 1.78515e-46 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q8IN81 289 3.5e-24 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00376//PF00196//PF00651//PF13411 MerR family regulatory protein//Bacterial regulatory proteins, luxR family//BTB/POZ domain//MerR HTH family regulatory protein GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.56867 BF_2 11.00 0.79 866 91084819 XP_973299.1 230 1.2e-16 PREDICTED: protein abrupt [Tribolium castaneum]>gi|270008590|gb|EFA05038.1| hypothetical protein TcasGA2_TC015126 [Tribolium castaneum] 642925929 XM_968206.2 79 4.63034e-31 PREDICTED: Tribolium castaneum protein abrupt (LOC662085), mRNA -- -- -- -- Q9W0K4 148 1.6e-08 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF08802 Cytochrome B6-F complex Fe-S subunit GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0051537//GO:0009496 2 iron, 2 sulfur cluster binding//plastoquinol--plastocyanin reductase activity GO:0042651//GO:0009512 thylakoid membrane//cytochrome b6f complex -- -- Cluster-8309.56869 BF_2 105.36 3.20 1666 751215591 XP_011160707.1 146 1.3e-06 PREDICTED: DNA ligase 1-like [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06374//PF01015 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)//Ribosomal S3Ae family GO:0015992//GO:0042254//GO:0006744//GO:0006814//GO:0006412//GO:0006120 proton transport//ribosome biogenesis//ubiquinone biosynthetic process//sodium ion transport//translation//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003735 NADH dehydrogenase (ubiquinone) activity//structural constituent of ribosome GO:0005622//GO:0005840//GO:0005743 intracellular//ribosome//mitochondrial inner membrane -- -- Cluster-8309.56870 BF_2 12.14 0.38 1616 91076754 XP_973519.1 846 8.3e-88 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG39 153 7.8e-09 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.56888 BF_2 8.00 0.61 832 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.56894 BF_2 16.00 4.23 445 678195957 KFV62939.1 624 1.3e-62 40S ribosomal protein S16, partial [Picoides pubescens] 835909321 XM_004548427.2 143 6.06902e-67 PREDICTED: Maylandia zebra ribosomal protein S16 (rps16), mRNA K02960 RP-S16e, RPS16 small subunit ribosomal protein S16e http://www.genome.jp/dbget-bin/www_bget?ko:K02960 P62250 619 2.0e-63 40S ribosomal protein S16 OS=Rattus norvegicus GN=Rps16 PE=1 SV=2 PF00380 Ribosomal protein S9/S16 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1753 40S ribosomal protein S16 Cluster-8309.56899 BF_2 41.27 5.85 582 270008916 EFA05364.1 523 8.6e-51 hypothetical protein TcasGA2_TC015529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07831 Pyrimidine nucleoside phosphorylase C-terminal domain GO:0006213 pyrimidine nucleoside metabolic process GO:0016763 transferase activity, transferring pentosyl groups -- -- -- -- Cluster-8309.56913 BF_2 15.74 0.36 2123 642911525 XP_008199459.1 1539 4.8e-168 PREDICTED: uncharacterized protein LOC662950 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P58659 355 3.9e-32 Protein eva-1 homolog C OS=Mus musculus GN=Eva1c PE=2 SV=2 PF02140 Galactose binding lectin domain -- -- GO:0030246 carbohydrate binding -- -- KOG4729 Galactoside-binding lectin Cluster-8309.56915 BF_2 40.37 0.86 2244 270001539 EEZ97986.1 1710 7.5e-188 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 285 3.75647e-145 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 838 4.0e-88 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF00076//PF16367 RNA binding motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003723//GO:0003676 RNA binding//nucleic acid binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.56918 BF_2 3.00 0.32 682 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56919 BF_2 11.41 0.79 894 149675194 ABR27684.1 861 8.4e-90 cuticle proprotein proCP3.2 [Callinectes sapidus] 149675193 EF639836.1 376 0 Callinectes sapidus cuticle proprotein proCP3.2 mRNA, complete cds -- -- -- -- P81582 372 1.7e-34 Cuticle protein CP1246 OS=Cancer pagurus PE=1 SV=1 PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.56920 BF_2 19.75 0.54 1816 642921367 XP_008192837.1 1071 7.6e-114 PREDICTED: arylsulfatase B-like [Tribolium castaneum]>gi|270006267|gb|EFA02715.1| hypothetical protein TcasGA2_TC008439 [Tribolium castaneum] -- -- -- -- -- K12375 ARSI_J arylsulfatase I/J http://www.genome.jp/dbget-bin/www_bget?ko:K12375 Q5FYB1 305 2.1e-26 Arylsulfatase I OS=Homo sapiens GN=ARSI PE=1 SV=1 PF00884 Sulfatase GO:0008152 metabolic process GO:0008484 sulfuric ester hydrolase activity -- -- KOG3867 Sulfatase Cluster-8309.56923 BF_2 10.00 83.63 238 -- -- -- -- -- 565671674 AB894124.1 40 5.4621e-10 Gryllus bimaculatus DNA, 7SK-like snRNA, 5' region sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56926 BF_2 50.26 0.45 4963 642918266 XP_008191438.1 5630 0.0e+00 PREDICTED: dual oxidase isoform X2 [Tribolium castaneum] 755988817 XM_011313677.1 459 0 PREDICTED: Fopius arisanus dual oxidase (LOC105271872), mRNA K13411 DUOX, THOX dual oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K13411 Q9VQH2 5133 0.0e+00 Dual oxidase OS=Drosophila melanogaster GN=Duox PE=1 SV=2 PF00036//PF08022//PF08030//PF13202//PF13833//PF13405//PF13499//PF12763 EF hand//FAD-binding domain//Ferric reductase NAD binding domain//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0005509 oxidoreductase activity//protein binding//calcium ion binding -- -- KOG0039 Ferric reductase, NADH/NADPH oxidase and related proteins Cluster-8309.56928 BF_2 2.99 0.33 663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56931 BF_2 25.00 0.46 2584 815916348 XP_012243339.1 270 8.3e-21 PREDICTED: collagen alpha-3(IX) chain-like isoform X1 [Bombus impatiens] -- -- -- -- -- K06237 COL4A collagen, type IV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K06237 Q07092 201 3.4e-14 Collagen alpha-1(XVI) chain OS=Homo sapiens GN=COL16A1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3544 Collagens (type IV and type XIII), and related proteins Cluster-8309.56936 BF_2 50.74 0.65 3560 91082383 XP_968748.1 2181 2.9e-242 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007500|gb|EFA03948.1| hypothetical protein TcasGA2_TC014092 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 1514 2.6e-166 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00931//PF02714//PF00664//PF02367//PF00005//PF03193 NB-ARC domain//Calcium-dependent channel, 7TM region, putative phosphate//ABC transporter transmembrane region//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ABC transporter//Protein of unknown function, DUF258 GO:0002949//GO:0006810//GO:0055085 tRNA threonylcarbamoyladenosine modification//transport//transmembrane transport GO:0017111//GO:0042626//GO:0005525//GO:0016887//GO:0043531//GO:0003924//GO:0005524 nucleoside-triphosphatase activity//ATPase activity, coupled to transmembrane movement of substances//GTP binding//ATPase activity//ADP binding//GTPase activity//ATP binding GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.56940 BF_2 51.23 0.68 3430 478263614 ENN81920.1 2165 2.0e-240 hypothetical protein YQE_01631, partial [Dendroctonus ponderosae] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 776 9.6e-81 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF02985 HEAT repeat -- -- GO:0005515 protein binding -- -- KOG3694 Protein required for meiosis Cluster-8309.56941 BF_2 86.00 2.35 1820 91090772 XP_969499.1 1733 1.3e-190 PREDICTED: rapamycin-insensitive companion of mTOR [Tribolium castaneum]>gi|270013969|gb|EFA10417.1| hypothetical protein TcasGA2_TC012657 [Tribolium castaneum] -- -- -- -- -- K08267 RICTOR rapamycin-insensitive companion of mTOR http://www.genome.jp/dbget-bin/www_bget?ko:K08267 Q6QI06 827 6.2e-87 Rapamycin-insensitive companion of mTOR OS=Mus musculus GN=Rictor PE=1 SV=2 PF05933 Fungal ATP synthase protein 8 (A6L) GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) KOG3694 Protein required for meiosis Cluster-8309.56946 BF_2 2.39 0.50 486 255522807 NP_001157316.1 172 3.6e-10 longitudinals lacking isoform 7 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13465//PF00096//PF07503 Zinc-finger double domain//Zinc finger, C2H2 type//HypF finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.56949 BF_2 30.71 1.38 1221 649572269 NP_001280526.1 494 4.1e-47 arylsulfatase B precursor [Tribolium castaneum]>gi|270008608|gb|EFA05056.1| hypothetical protein TcasGA2_TC015151 [Tribolium castaneum]>gi|521762944|gb|AGQ03798.1| arylsulfatase b [Tribolium castaneum] -- -- -- -- -- K01135 ARSB arylsulfatase B http://www.genome.jp/dbget-bin/www_bget?ko:K01135 P50430 295 2.0e-25 Arylsulfatase B OS=Rattus norvegicus GN=Arsb PE=2 SV=2 PF02319//PF00884//PF01232 E2F/DP family winged-helix DNA-binding domain//Sulfatase//Mannitol dehydrogenase Rossmann domain GO:0008152//GO:0006355//GO:0055114 metabolic process//regulation of transcription, DNA-templated//oxidation-reduction process GO:0008484//GO:0003700//GO:0016491 sulfuric ester hydrolase activity//transcription factor activity, sequence-specific DNA binding//oxidoreductase activity GO:0005667 transcription factor complex KOG3867 Sulfatase Cluster-8309.56953 BF_2 112.36 1.01 4948 642914971 XP_008190464.1 1080 1.9e-114 PREDICTED: SURP and G-patch domain-containing protein 1-like isoform X1 [Tribolium castaneum] 642914972 XM_008192243.1 72 2.12693e-26 PREDICTED: Tribolium castaneum SURP and G-patch domain-containing protein 1-like (LOC103312198), transcript variant X2, mRNA K13096 SF4 splicing factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13096 Q8CH02 461 4.6e-44 SURP and G-patch domain-containing protein 1 OS=Mus musculus GN=Sugp1 PE=1 SV=1 PF05680//PF06703//PF00322//PF01585 ATP synthase E chain//Microsomal signal peptidase 25 kDa subunit (SPC25)//Endothelin family//G-patch domain GO:0019229//GO:0006465//GO:0015986//GO:0015992 regulation of vasoconstriction//signal peptide processing//ATP synthesis coupled proton transport//proton transport GO:0003676//GO:0015078//GO:0008233 nucleic acid binding//hydrogen ion transmembrane transporter activity//peptidase activity GO:0016021//GO:0005576//GO:0000276//GO:0005787 integral component of membrane//extracellular region//mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//signal peptidase complex KOG0965 Predicted RNA-binding protein, contains SWAP and G-patch domains Cluster-8309.56957 BF_2 7.76 0.54 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56960 BF_2 43.03 1.19 1801 817203425 XP_012277535.1 2445 3.6e-273 PREDICTED: TFIIH basal transcription factor complex helicase XPD subunit isoform X1 [Orussus abietinus] 572310025 XM_006620723.1 362 0 PREDICTED: Apis dorsata TFIIH basal transcription factor complex helicase XPD subunit-like (LOC102676342), mRNA K10844 ERCC2, XPD DNA excision repair protein ERCC-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10844 O08811 2148 4.1e-240 TFIIH basal transcription factor complex helicase XPD subunit OS=Mus musculus GN=Ercc2 PE=2 SV=2 PF00176//PF06733//PF06777//PF13307 SNF2 family N-terminal domain//DEAD_2//Helical and beta-bridge domain//Helicase C-terminal domain GO:0006139 nucleobase-containing compound metabolic process GO:0004003//GO:0003676//GO:0016818//GO:0005524//GO:0003677//GO:0008026 ATP-dependent DNA helicase activity//nucleic acid binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//ATP binding//DNA binding//ATP-dependent helicase activity GO:0005657//GO:0005634 replication fork//nucleus KOG1131 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, 5'-3' helicase subunit RAD3 Cluster-8309.56962 BF_2 1.00 0.45 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56963 BF_2 170.81 5.51 1583 270012124 EFA08572.1 1174 7.6e-126 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI23 400 1.8e-37 Protein yellow OS=Drosophila erecta GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56965 BF_2 44.61 1.28 1742 270012124 EFA08572.1 1174 8.3e-126 hypothetical protein TcasGA2_TC006227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BI17 400 1.9e-37 Protein yellow OS=Drosophila yakuba GN=y PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.56969 BF_2 12.15 0.37 1647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.56971 BF_2 5.00 0.35 893 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56974 BF_2 22.49 0.42 2530 189242412 XP_001810435.1 145 2.5e-06 PREDICTED: glycine-rich cell wall structural protein 1.8 isoform X1 [Tribolium castaneum]>gi|270016263|gb|EFA12709.1| hypothetical protein TcasGA2_TC002343 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56980 BF_2 23.07 0.88 1384 741829289 AJA91071.1 322 4.1e-27 cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 247 8.4e-20 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.56982 BF_2 36.46 0.65 2640 642935245 XP_008197928.1 1903 3.7e-210 PREDICTED: Down syndrome cell adhesion molecule isoform X1 [Tribolium castaneum] 642935246 XM_008199707.1 311 1.55981e-159 PREDICTED: Tribolium castaneum Down syndrome cell adhesion molecule (Dscam), transcript variant X2, mRNA -- -- -- -- Q9VS29 847 4.3e-89 Down syndrome cell adhesion molecule-like protein Dscam2 OS=Drosophila melanogaster GN=Dscam2 PE=2 SV=3 PF05790//PF13895 Immunoglobulin C2-set domain//Immunoglobulin domain GO:0007155 cell adhesion GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.56983 BF_2 10.10 0.50 1124 546684870 ERL94452.1 181 7.5e-11 hypothetical protein D910_11729 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56984 BF_2 11.41 0.77 908 641659246 XP_008181021.1 191 4.2e-12 PREDICTED: uncharacterized protein LOC103308774 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56985 BF_2 22.39 3.31 570 86515366 NP_001034509.1 510 2.7e-49 Sp-like zinc finger transcription factor [Tribolium castaneum]>gi|34979121|gb|AAQ83696.1| Sp-like zinc finger protein [Tribolium castaneum]>gi|270014240|gb|EFA10688.1| lethal Sp8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.56990 BF_2 17.00 0.32 2518 642921017 XP_008192656.1 2954 0.0e+00 PREDICTED: potassium voltage-gated channel protein eag isoform X2 [Tribolium castaneum] 33327423 AF528521.1 366 0 Manduca sexta Eag K+ channel mRNA, complete cds K05322 KCNHN potassium voltage-gated channel Eag-related subfamily H, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05322 Q02280 1796 3.7e-199 Potassium voltage-gated channel protein eag OS=Drosophila melanogaster GN=eag PE=1 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane KOG0501 K+-channel KCNQ Cluster-8309.56991 BF_2 24.65 0.90 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.56998 BF_2 3.00 0.71 463 768417985 XP_011549659.1 215 3.5e-15 PREDICTED: tigger transposable element-derived protein 6-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57001 BF_2 15.00 0.57 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.57014 BF_2 229.42 8.28 1446 642920832 XP_008192577.1 771 3.7e-79 PREDICTED: lipase 3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46108 682 3.2e-70 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF02450//PF04083 Lecithin:cholesterol acyltransferase//Partial alpha/beta-hydrolase lipase region GO:0042967//GO:0006629 acyl-carrier-protein biosynthetic process//lipid metabolic process GO:0008374 O-acyltransferase activity -- -- -- -- Cluster-8309.57016 BF_2 44.46 0.63 3233 642926395 XP_970524.2 623 1.2e-61 PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926397|ref|XP_008191945.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum]>gi|642926399|ref|XP_008191946.1| PREDICTED: ras-related protein Rab-9A [Tribolium castaneum] -- -- -- -- -- K07900 RAB9B Ras-related protein Rab-9B http://www.genome.jp/dbget-bin/www_bget?ko:K07900 Q8BHH2 504 3.1e-49 Ras-related protein Rab-9B OS=Mus musculus GN=Rab9b PE=2 SV=1 PF00735//PF08477//PF01926//PF00025//PF03193//PF01637//PF04670//PF00071 Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//ADP-ribosylation factor family//Protein of unknown function, DUF258//Archaeal ATPase//Gtr1/RagA G protein conserved region//Ras family GO:0007264 small GTPase mediated signal transduction GO:0005524//GO:0005525//GO:0003924 ATP binding//GTP binding//GTPase activity -- -- KOG0394 Ras-related GTPase Cluster-8309.57019 BF_2 69.64 1.87 1849 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57023 BF_2 43.21 1.30 1676 642929319 XP_008195785.1 1361 1.7e-147 PREDICTED: stomatin-like protein 2, mitochondrial isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9UJZ1 1028 2.8e-110 Stomatin-like protein 2, mitochondrial OS=Homo sapiens GN=STOML2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2620 Prohibitins and stomatins of the PID superfamily Cluster-8309.57024 BF_2 89.94 8.06 754 646718741 KDR21110.1 331 2.0e-28 Equilibrative nucleoside transporter 3 [Zootermopsis nevadensis] 826449622 XM_012676530.1 36 3.20915e-07 PREDICTED: Monomorium pharaonis equilibrative nucleoside transporter 1 (LOC105834216), mRNA -- -- -- -- Q9BZD2 236 8.7e-19 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.57025 BF_2 24.29 1.36 1035 156552507 XP_001602781.1 297 2.4e-24 PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis]>gi|645012566|ref|XP_008207864.1| PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01733 Nucleoside transporter GO:0006810//GO:0015858 transport//nucleoside transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57026 BF_2 54.40 3.24 989 156552507 XP_001602781.1 313 3.3e-26 PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis]>gi|645012566|ref|XP_008207864.1| PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57027 BF_2 28.31 1.62 1019 156552507 XP_001602781.1 297 2.4e-24 PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis]>gi|645012566|ref|XP_008207864.1| PREDICTED: equilibrative nucleoside transporter 1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57029 BF_2 112.44 2.48 2183 642912341 XP_008199603.1 2987 0.0e+00 PREDICTED: DNA polymerase delta catalytic subunit [Tribolium castaneum]>gi|270002921|gb|EEZ99368.1| DNA polymerase delta [Tribolium castaneum] 324120713 AB598708.1 168 4.00461e-80 Euconocephalus varius DPD1 mRNA for DNA polymerase delta catalytic subunit, complete cds, isolate: 7 K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 2376 1.8e-266 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF03175//PF00136//PF03104 DNA polymerase type B, organellar and viral//DNA polymerase family B//DNA polymerase family B, exonuclease domain GO:0006260 DNA replication GO:0000166//GO:0008408//GO:0003677//GO:0003887 nucleotide binding//3'-5' exonuclease activity//DNA binding//DNA-directed DNA polymerase activity GO:0042575 DNA polymerase complex KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.57030 BF_2 122.28 1.32 4152 91091528 XP_970224.1 1670 6.1e-183 PREDICTED: myrosinase 1-like [Tribolium castaneum] -- -- -- -- -- K01229 LCT lactase-phlorizin hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K01229 Q95X01 1130 1.0e-121 Myrosinase 1 OS=Brevicoryne brassicae PE=1 SV=1 PF01491//PF00232//PF00150//PF02926//PF03233 Frataxin-like domain//Glycosyl hydrolase family 1//Cellulase (glycosyl hydrolase family 5)//THUMP domain//Aphid transmission protein GO:0019089//GO:0005975//GO:0016226 transmission of virus//carbohydrate metabolic process//iron-sulfur cluster assembly GO:0004553//GO:0003723//GO:0008199 hydrolase activity, hydrolyzing O-glycosyl compounds//RNA binding//ferric iron binding -- -- KOG0626 Beta-glucosidase, lactase phlorizinhydrolase, and related proteins Cluster-8309.57034 BF_2 53.07 0.32 7212 861627690 KMQ89153.1 611 6.6e-60 molybdopterin synthase catalytic subunit-like protein [Lasius niger] -- -- -- -- -- K03635 MOCS2, moaE molybdopterin synthase catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K03635 B5FXU9 479 5.5e-46 Molybdopterin synthase catalytic subunit OS=Taeniopygia guttata GN=MOCS2 PE=2 SV=1 PF02391//PF00400 MoaE protein//WD domain, G-beta repeat GO:0006777 Mo-molybdopterin cofactor biosynthetic process GO:0005515 protein binding -- -- KOG3307 Molybdopterin converting factor subunit 2 Cluster-8309.57036 BF_2 5.00 0.32 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57039 BF_2 55.97 1.34 2032 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57041 BF_2 2.00 1.11 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5705 BF_2 2.00 0.61 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57052 BF_2 304.78 2.24 5987 478255012 ENN75245.1 1054 2.4e-111 hypothetical protein YQE_08254, partial [Dendroctonus ponderosae] -- -- -- -- -- K10684 UBLE1A, SAE1 ubiquitin-like 1-activating enzyme E1 A http://www.genome.jp/dbget-bin/www_bget?ko:K10684 Q28DS0 490 2.4e-47 SUMO-activating enzyme subunit 1 OS=Xenopus tropicalis GN=sae1 PE=2 SV=1 PF07243//PF00899 Phlebovirus glycoprotein G1//ThiF family -- -- GO:0008641 small protein activating enzyme activity GO:0016021//GO:0019012 integral component of membrane//virion KOG2014 SMT3/SUMO-activating complex, AOS1/RAD31 component Cluster-8309.57058 BF_2 60.27 4.04 911 478259929 ENN79731.1 758 7.5e-78 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBP8 440 2.3e-42 Methyltransferase-like protein 17, mitochondrial OS=Bos taurus GN=METTL17 PE=2 SV=1 PF09243//PF02285 Mitochondrial small ribosomal subunit Rsm22//Cytochrome oxidase c subunit VIII GO:0006123//GO:0006412//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//translation//proton transport GO:0008168//GO:0004129 methyltransferase activity//cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.57061 BF_2 4.00 0.46 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57071 BF_2 101.57 8.35 796 646709824 KDR15513.1 260 3.7e-20 hypothetical protein L798_10579 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q5ZLK8 234 1.6e-18 UPF0669 protein C6orf120 homolog OS=Gallus gallus GN=RCJMB04_5l6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57072 BF_2 27.56 1.69 971 759053515 XP_011335928.1 222 1.1e-15 PREDICTED: DNA repair endonuclease XPF [Cerapachys biroi] -- -- -- -- -- K10848 ERCC4, XPF DNA excision repair protein ERCC-4 http://www.genome.jp/dbget-bin/www_bget?ko:K10848 Q5ZLK8 183 1.6e-12 UPF0669 protein C6orf120 homolog OS=Gallus gallus GN=RCJMB04_5l6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57075 BF_2 33.86 0.91 1845 478264795 ENN82329.1 823 4.4e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 7.7e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.57076 BF_2 115.37 4.53 1352 546679352 ERL89827.1 823 3.2e-85 hypothetical protein D910_07187 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 5.6e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.57077 BF_2 35.43 1.07 1675 478264795 ENN82329.1 823 4.0e-85 hypothetical protein YQE_01295, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9NK57 602 7.0e-61 NIF3-like protein 1 OS=Drosophila melanogaster GN=anon-35F/36A PE=2 SV=3 PF08088 Conotoxin I-superfamily GO:0009405 pathogenesis -- -- GO:0005576 extracellular region KOG4131 Ngg1-interacting factor 3 protein NIF3L1 Cluster-8309.57082 BF_2 19.00 0.65 1510 380042040 AFD33363.1 1818 1.5e-200 G protein beta 1 [Scylla paramamosain] 380042039 JQ218936.1 1409 0 Scylla paramamosain G protein beta 1 mRNA, complete cds K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 O45040 1802 4.5e-200 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Homarus americanus GN=GBETA1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.57084 BF_2 14.80 0.40 1854 642923410 XP_974378.3 454 2.7e-42 PREDICTED: repressor of RNA polymerase III transcription MAF1 homolog [Tribolium castaneum]>gi|270007640|gb|EFA04088.1| hypothetical protein TcasGA2_TC014322 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PGU2 367 1.4e-33 Repressor of RNA polymerase III transcription MAF1 homolog OS=Danio rerio GN=maf1 PE=2 SV=1 -- -- GO:0016480 negative regulation of transcription from RNA polymerase III promoter -- -- GO:0005634 nucleus KOG3104 Mod5 protein sorting/negative effector of RNA Pol III synthesis Cluster-8309.57085 BF_2 1.00 0.44 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57086 BF_2 121.00 2.72 2149 642938239 XP_008198124.1 1112 1.6e-118 PREDICTED: coiled-coil domain-containing protein 174 [Tribolium castaneum]>gi|270016809|gb|EFA13255.1| hypothetical protein TcasGA2_TC001525 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5PQS7 415 4.3e-39 Coiled-coil domain-containing protein 174 OS=Rattus norvegicus GN=Ccdc174 PE=2 SV=2 PF01047 MarR family GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.57088 BF_2 20.58 0.71 1497 675372920 KFM65822.1 146 1.1e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236 Glycoprotein hormone GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.57089 BF_2 50.09 0.77 3008 675372920 KFM65822.1 146 2.3e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01429//PF05485//PF03950//PF08782//PF00236 Methyl-CpG binding domain//THAP domain//tRNA synthetases class I (E and Q), anti-codon binding domain//c-SKI Smad4 binding domain//Glycoprotein hormone GO:0007165//GO:0006418 signal transduction//tRNA aminoacylation for protein translation GO:0005524//GO:0003677//GO:0005179//GO:0000166//GO:0003676//GO:0004812//GO:0046332 ATP binding//DNA binding//hormone activity//nucleotide binding//nucleic acid binding//aminoacyl-tRNA ligase activity//SMAD binding GO:0005634//GO:0005576//GO:0005737 nucleus//extracellular region//cytoplasm -- -- Cluster-8309.57093 BF_2 15.55 0.53 1510 675372920 KFM65822.1 140 5.7e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236 Glycoprotein hormone GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.57096 BF_2 38.57 0.59 3021 675372920 KFM65822.1 146 2.3e-06 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF03950//PF00619 THAP domain//tRNA synthetases class I (E and Q), anti-codon binding domain//Caspase recruitment domain GO:0006418//GO:0042981 tRNA aminoacylation for protein translation//regulation of apoptotic process GO:0005524//GO:0000166//GO:0003676//GO:0004812 ATP binding//nucleotide binding//nucleic acid binding//aminoacyl-tRNA ligase activity GO:0005737 cytoplasm -- -- Cluster-8309.57106 BF_2 36.99 1.14 1650 642925861 XP_008190588.1 1004 4.1e-106 PREDICTED: osmotic avoidance abnormal protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P46873 372 3.2e-34 Osmotic avoidance abnormal protein 3 OS=Caenorhabditis elegans GN=osm-3 PE=2 SV=4 PF01618 MotA/TolQ/ExbB proton channel family GO:0006810//GO:0015031 transport//protein transport GO:0008565 protein transporter activity GO:0016020 membrane KOG4280 Kinesin-like protein Cluster-8309.57108 BF_2 33.00 2.69 801 478255797 ENN76005.1 479 1.5e-45 hypothetical protein YQE_07385, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8T635 326 3.4e-29 Pupal cuticle protein 20 OS=Manduca sexta GN=PCP20 PE=1 SV=1 PF15761//PF00379 Immortalisation up-regulated protein//Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle GO:0005634 nucleus -- -- Cluster-8309.57109 BF_2 55.22 2.04 1421 91078956 XP_974192.1 719 3.9e-73 PREDICTED: protein prune homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BIW1 423 3.4e-40 Protein prune homolog OS=Mus musculus GN=Prune PE=2 SV=1 PF02833 DHHA2 domain -- -- GO:0016462 pyrophosphatase activity GO:0005737 cytoplasm KOG4129 Exopolyphosphatases and related proteins Cluster-8309.57113 BF_2 228.27 5.15 2140 125979697 XP_001353881.1 237 4.6e-17 GA19831 [Drosophila pseudoobscura pseudoobscura]>gi|54640865|gb|EAL29616.1| GA19831 [Drosophila pseudoobscura pseudoobscura] -- -- -- -- -- -- -- -- -- O55226 173 5.0e-11 Chondroadherin OS=Mus musculus GN=Chad PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.57114 BF_2 33.73 0.45 3437 260832388 XP_002611139.1 232 2.8e-16 hypothetical protein BRAFLDRAFT_88462 [Branchiostoma floridae]>gi|229296510|gb|EEN67149.1| hypothetical protein BRAFLDRAFT_88462 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- O55226 189 1.1e-12 Chondroadherin OS=Mus musculus GN=Chad PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.57117 BF_2 158.63 1.48 4774 478255769 ENN75978.1 183 1.9e-10 hypothetical protein YQE_07511, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07517//PF02179//PF00816//PF07544//PF04905 SecA DEAD-like domain//BAG domain//H-NS histone family//RNA polymerase II transcription mediator complex subunit 9//NAB conserved region 2 (NCD2) GO:0006355//GO:0006357//GO:0045892//GO:0017038 regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//negative regulation of transcription, DNA-templated//protein import GO:0051087//GO:0001104//GO:0003677//GO:0005524 chaperone binding//RNA polymerase II transcription cofactor activity//DNA binding//ATP binding GO:0005622//GO:0016020//GO:0005634//GO:0016592 intracellular//membrane//nucleus//mediator complex -- -- Cluster-8309.57120 BF_2 22.93 0.42 2570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57124 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57127 BF_2 37.55 0.47 3615 642928611 XP_008199978.1 2290 6.8e-255 PREDICTED: FERM domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3UFK8 547 3.6e-54 FERM domain-containing protein 8 OS=Mus musculus GN=Frmd8 PE=1 SV=2 PF04218//PF01527 CENP-B N-terminal DNA-binding domain//Transposase GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG4335 FERM domain-containing protein KRIT1 Cluster-8309.57128 BF_2 54.00 5.23 719 478253867 ENN74159.1 296 2.2e-24 hypothetical protein YQE_09132, partial [Dendroctonus ponderosae]>gi|546684676|gb|ERL94293.1| hypothetical protein D910_11574 [Dendroctonus ponderosae] -- -- -- -- -- K17779 TIM10B mitochondrial import inner membrane translocase subunit TIM10B http://www.genome.jp/dbget-bin/www_bget?ko:K17779 Q568N4 217 1.3e-16 Mitochondrial import inner membrane translocase subunit Tim10 B OS=Danio rerio GN=timm10b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3479 Mitochondrial import inner membrane translocase, subunit TIM9 Cluster-8309.57129 BF_2 326.00 3.12 4664 189237968 XP_001811946.1 3393 0.0e+00 PREDICTED: TBC1 domain family member 25 isoform X1 [Tribolium castaneum]>gi|270008039|gb|EFA04487.1| hypothetical protein TcasGA2_TC014792 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MII6 1090 5.0e-117 TBC1 domain family member 25 OS=Homo sapiens GN=TBC1D25 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2197 Ypt/Rab-specific GTPase-activating protein GYP7 and related proteins Cluster-8309.57131 BF_2 9.68 1.61 539 642924854 XP_008194067.1 393 9.4e-36 PREDICTED: LOW QUALITY PROTEIN: protein mahjong [Tribolium castaneum] -- -- -- -- -- K11789 VPRBP, DCAF1 HIV-1 Vpr-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K11789 Q9W2F2 247 3.3e-20 Protein mahjong OS=Drosophila melanogaster GN=mahj PE=1 SV=2 PF08513 LisH -- -- GO:0005515 protein binding -- -- KOG1832 HIV-1 Vpr-binding protein Cluster-8309.57133 BF_2 367.00 5.59 3034 546684589 ERL94206.1 2029 1.0e-224 hypothetical protein D910_11487, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5VU97 1138 8.9e-123 VWFA and cache domain-containing protein 1 OS=Homo sapiens GN=CACHD1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57144 BF_2 152.57 1.55 4402 444518819 ELV12406.1 411 6.3e-37 Zinc finger protein 717 [Tupaia chinensis] 642932060 XM_008198621.1 176 2.90601e-84 PREDICTED: Tribolium castaneum protein lin-54 homolog (LOC663835), transcript variant X3, mRNA -- -- -- -- Q6P560 406 9.8e-38 Zinc finger protein 182 OS=Mus musculus GN=Znf182 PE=2 SV=1 PF07975//PF13465//PF00096//PF01428//PF16622//PF00412//PF13912 TFIIH C1-like domain//Zinc-finger double domain//Zinc finger, C2H2 type//AN1-like Zinc finger//zinc-finger C2H2-type//LIM domain//C2H2-type zinc finger GO:0006281 DNA repair GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.57150 BF_2 23.00 0.61 1861 602643062 XP_007444770.1 578 1.1e-56 PREDICTED: zinc finger protein 91-like, partial [Python bivittatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9HCG1 548 1.4e-54 Zinc finger protein 160 OS=Homo sapiens GN=ZNF160 PE=2 SV=3 PF13465//PF00096//PF13912//PF02892//PF07776//PF16622//PF06467 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//BED zinc finger//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//MYM-type Zinc finger with FCS sequence motif -- -- GO:0046872//GO:0008270//GO:0003677 metal ion binding//zinc ion binding//DNA binding GO:0005634 nucleus -- -- Cluster-8309.57152 BF_2 94.39 1.17 3653 642923250 XP_008193676.1 4383 0.0e+00 PREDICTED: E3 ubiquitin-protein ligase MIB2 [Tribolium castaneum]>gi|270007080|gb|EFA03528.1| hypothetical protein TcasGA2_TC013531 [Tribolium castaneum] 642923249 XM_008195454.1 66 3.3902e-23 PREDICTED: Tribolium castaneum E3 ubiquitin-protein ligase MIB2 (LOC659647), mRNA K10645 MIB E3 ubiquitin-protein ligase mind-bomb http://www.genome.jp/dbget-bin/www_bget?ko:K10645 Q5ZIJ9 1810 1.3e-200 E3 ubiquitin-protein ligase MIB2 OS=Gallus gallus GN=MIB2 PE=2 SV=1 PF00569//PF06701//PF07649//PF13606//PF00097//PF00023 Zinc finger, ZZ type//Mib_herc2//C1-like domain//Ankyrin repeat//Zinc finger, C3HC4 type (RING finger)//Ankyrin repeat GO:0055114//GO:0016567 oxidation-reduction process//protein ubiquitination GO:0008270//GO:0004842//GO:0047134//GO:0046872//GO:0005515 zinc ion binding//ubiquitin-protein transferase activity//protein-disulfide reductase activity//metal ion binding//protein binding -- -- -- -- Cluster-8309.57154 BF_2 54.43 0.93 2727 270006862 EFA03310.1 266 2.5e-20 hypothetical protein TcasGA2_TC013252 [Tribolium castaneum] -- -- -- -- -- K10268 FBXL2_20 F-box and leucine-rich repeat protein 2/20 http://www.genome.jp/dbget-bin/www_bget?ko:K10268 Q9CZV8 145 1.1e-07 F-box/LRR-repeat protein 20 OS=Mus musculus GN=Fbxl20 PE=1 SV=3 PF12937//PF15966//PF00646 F-box-like//F-box//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57155 BF_2 24.84 0.57 2116 591358663 XP_007054313.1 142 4.7e-06 PREDICTED: serine/arginine-rich splicing factor 5-like isoform X2 [Chelonia mydas] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.57158 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57166 BF_2 1.00 0.47 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57168 BF_2 68.88 3.91 1024 642927610 XP_008195334.1 722 1.3e-73 PREDICTED: conserved oligomeric Golgi complex subunit 1 [Tribolium castaneum]>gi|270011053|gb|EFA07501.1| pebbled [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VGC3 246 8.1e-20 Conserved oligomeric Golgi complex subunit 1 OS=Drosophila melanogaster GN=CG4848 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57169 BF_2 5.11 0.31 973 646700583 KDR10693.1 354 5.6e-31 Propionyl-CoA carboxylase alpha chain, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- K01965 PCCA, pccA propionyl-CoA carboxylase alpha chain http://www.genome.jp/dbget-bin/www_bget?ko:K01965 Q91ZA3 296 1.2e-25 Propionyl-CoA carboxylase alpha chain, mitochondrial OS=Mus musculus GN=Pcca PE=1 SV=2 PF07478//PF02786//PF02655 D-ala D-ala ligase C-terminus//Carbamoyl-phosphate synthase L chain, ATP binding domain//ATP-grasp domain GO:0046436//GO:0009252 D-alanine metabolic process//peptidoglycan biosynthetic process GO:0008716//GO:0046872//GO:0005524 D-alanine-D-alanine ligase activity//metal ion binding//ATP binding -- -- KOG0238 3-Methylcrotonyl-CoA carboxylase, biotin-containing subunit/Propionyl-CoA carboxylase, alpha chain/Acetyl-CoA carboxylase, biotin carboxylase subunit Cluster-8309.57172 BF_2 14.50 1.02 884 665790563 XP_008560974.1 184 2.6e-11 PREDICTED: pro-resilin [Microplitis demolitor] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57174 BF_2 160.00 7.22 1214 674304042 AIL23552.1 749 1.1e-76 glutathione S-transferase theta [Tenebrio molitor] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q01579 427 9.9e-41 Glutathione S-transferase theta-1 OS=Rattus norvegicus GN=Gstt1 PE=1 SV=2 PF02798//PF13417//PF04061//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//ORMDL family//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG0867 Glutathione S-transferase Cluster-8309.57177 BF_2 2.39 0.49 491 642917716 XP_008191343.1 233 3.1e-17 PREDICTED: ecotropic viral integration site 5 ortholog isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57179 BF_2 5.00 1.07 483 546676696 ERL87652.1 327 3.8e-28 hypothetical protein D910_05043 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9W0K7 145 2.0e-08 Protein bric-a-brac 1 OS=Drosophila melanogaster GN=bab1 PE=2 SV=2 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57181 BF_2 30.13 1.60 1074 270012943 EFA09391.1 534 8.4e-52 hypothetical protein TcasGA2_TC004309 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12937//PF00646 F-box-like//F-box domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57184 BF_2 26.00 1.36 1087 321466115 EFX77112.1 1058 1.5e-112 hypothetical protein DAPPUDRAFT_231133 [Daphnia pulex] 307352166 HM143923.2 606 0 Eriocheir sinensis voltage-dependent anion-selective channel mRNA, complete cds K15040 VDAC2 voltage-dependent anion channel protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15040 P82013 946 5.9e-101 Voltage-dependent anion-selective channel protein 2 OS=Meleagris gallopavo GN=VDAC2 PE=1 SV=1 PF01459 Eukaryotic porin GO:0055085 transmembrane transport -- -- GO:0005741 mitochondrial outer membrane KOG3126 Porin/voltage-dependent anion-selective channel protein Cluster-8309.57187 BF_2 133.34 1.57 3837 478249703 ENN70211.1 2096 2.2e-232 hypothetical protein YQE_12997, partial [Dendroctonus ponderosae] -- -- -- -- -- K05644 ABCA4 ATP-binding cassette, subfamily A (ABC1), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05644 Q99758 1020 5.4e-109 ATP-binding cassette sub-family A member 3 OS=Homo sapiens GN=ABCA3 PE=1 SV=2 PF03152//PF02170//PF13304//PF00005 Ubiquitin fusion degradation protein UFD1//PAZ domain//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter GO:0006511 ubiquitin-dependent protein catabolic process GO:0005515//GO:0005524//GO:0016887 protein binding//ATP binding//ATPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.57188 BF_2 157.33 0.99 6920 642935081 XP_008197876.1 3574 0.0e+00 PREDICTED: calmodulin-binding transcription activator 2-like isoform X2 [Tribolium castaneum] 642935084 XM_008199656.1 481 0 PREDICTED: Tribolium castaneum calmodulin-binding transcription activator 2-like (LOC656966), transcript variant X4, mRNA -- -- -- -- Q9Y6Y1 557 4.8e-55 Calmodulin-binding transcription activator 1 OS=Homo sapiens GN=CAMTA1 PE=1 SV=4 PF13606//PF01833//PF00612//PF00023 Ankyrin repeat//IPT/TIG domain//IQ calmodulin-binding motif//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG0520 Uncharacterized conserved protein, contains IPT/TIG domain Cluster-8309.57189 BF_2 60.93 1.42 2079 642933652 XP_975152.2 513 4.4e-49 PREDICTED: nucleoporin-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB98 180 7.5e-12 Nucleoporin-like protein 2 OS=Pongo abelii GN=NUPL2 PE=2 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57190 BF_2 17.84 0.40 2136 642933410 XP_008197405.1 1792 2.2e-197 PREDICTED: sodium-independent sulfate anion transporter isoform X2 [Tribolium castaneum] 672070250 XM_006247940.2 44 3.34327e-11 PREDICTED: Rattus norvegicus solute carrier family 26 (anion exchanger), member 11 (Slc26a11), transcript variant X4, mRNA K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q86WA9 882 3.0e-93 Sodium-independent sulfate anion transporter OS=Homo sapiens GN=SLC26A11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.57192 BF_2 19.00 0.76 1338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57193 BF_2 1.00 1.26 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57194 BF_2 6.00 0.39 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57198 BF_2 14.06 0.40 1750 571330978 AHF27421.1 1325 2.6e-143 putative sugar transporter 10 [Phaedon cochleariae] -- -- -- -- -- -- -- -- -- Q17NV8 399 2.5e-37 Facilitated trehalose transporter Tret1 OS=Aedes aegypti GN=Tret1 PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0254 Predicted transporter (major facilitator superfamily) Cluster-8309.57200 BF_2 29.81 1.02 1506 642932300 XP_008197055.1 454 2.2e-42 PREDICTED: protein UXT isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A7T0W1 170 7.8e-11 Protein UXT homolog OS=Nematostella vectensis GN=v1g140887 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57207 BF_2 18.00 0.66 1432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57208 BF_2 47.10 2.00 1274 642938702 XP_001809371.2 733 8.3e-75 PREDICTED: PWWP domain-containing protein 2A-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57211 BF_2 54.47 0.34 6945 642916413 XP_008191014.1 2582 1.8e-288 PREDICTED: uncharacterized protein LOC664255 isoform X4 [Tribolium castaneum] -- -- -- -- -- K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 9.9e-77 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF00595//PF13180//PF02198//PF00536//PF08040//PF07647 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Sterile alpha motif (SAM)/Pointed domain//SAM domain (Sterile alpha motif)//MNLL subunit//SAM domain (Sterile alpha motif) GO:0006118 obsolete electron transport GO:0005515//GO:0003954//GO:0043565 protein binding//NADH dehydrogenase activity//sequence-specific DNA binding GO:0005739//GO:0005634 mitochondrion//nucleus KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.57212 BF_2 158.40 0.99 6957 270003642 EFA00090.1 2579 4.0e-288 hypothetical protein TcasGA2_TC002905 [Tribolium castaneum] 642916410 XM_008192791.1 112 1.74015e-48 PREDICTED: Tribolium castaneum uncharacterized LOC664255 (LOC664255), transcript variant X3, mRNA K17551 PPP1R9 neurabin http://www.genome.jp/dbget-bin/www_bget?ko:K17551 O35867 744 9.9e-77 Neurabin-1 OS=Rattus norvegicus GN=Ppp1r9a PE=1 SV=1 PF08040//PF07647//PF00536//PF13180//PF02198//PF00595 MNLL subunit//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//PDZ domain//Sterile alpha motif (SAM)/Pointed domain//PDZ domain (Also known as DHR or GLGF) GO:0006118 obsolete electron transport GO:0043565//GO:0005515//GO:0003954 sequence-specific DNA binding//protein binding//NADH dehydrogenase activity GO:0005634//GO:0005739 nucleus//mitochondrion KOG1945 Protein phosphatase 1 binding protein spinophilin/neurabin II Cluster-8309.5722 BF_2 3.00 1.28 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03554//PF03037 UL73 viral envelope glycoprotein//Kinetoplastid membrane protein 11 GO:0008284//GO:0006952 positive regulation of cell proliferation//defense response -- -- GO:0019031 viral envelope -- -- Cluster-8309.57225 BF_2 35.45 1.70 1162 478257455 ENN77611.1 137 9.8e-06 hypothetical protein YQE_05906, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57226 BF_2 1.00 1.11 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57227 BF_2 0.80 0.78 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57233 BF_2 17.05 0.39 2123 357619502 EHJ72047.1 176 5.4e-10 hypothetical protein KGM_02999 [Danaus plexippus] -- -- -- -- -- K00314 SARDH sarcosine dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00314 Q99LB7 152 1.3e-08 Sarcosine dehydrogenase, mitochondrial OS=Mus musculus GN=Sardh PE=1 SV=1 PF01136 Peptidase family U32 GO:0006508 proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-8309.57236 BF_2 62.21 0.48 5732 189236323 XP_975243.2 2714 7.3e-304 PREDICTED: condensin complex subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9YHY6 1375 5.6e-150 Condensin complex subunit 1 OS=Xenopus laevis GN=ncapd2 PE=1 SV=1 PF02985//PF05434//PF04888 HEAT repeat//TMEM9//Secretion system effector C (SseC) like family GO:0009405 pathogenesis GO:0005515 protein binding GO:0016021 integral component of membrane KOG0414 Chromosome condensation complex Condensin, subunit D2 Cluster-8309.57241 BF_2 65.64 0.61 4824 270002629 EEZ99076.1 1236 1.5e-132 hypothetical protein TcasGA2_TC004955 [Tribolium castaneum] 195109814 XM_001999441.1 35 7.67072e-06 Drosophila mojavensis GI24529 (Dmoj\GI24529), mRNA -- -- -- -- Q26474 379 1.5e-34 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.57242 BF_2 139.28 1.24 4971 642912674 XP_008200959.1 1236 1.5e-132 PREDICTED: lachesin-like [Tribolium castaneum] 195109814 XM_001999441.1 35 7.90622e-06 Drosophila mojavensis GI24529 (Dmoj\GI24529), mRNA -- -- -- -- Q26474 379 1.5e-34 Lachesin OS=Schistocerca americana GN=LAC PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.57244 BF_2 279.25 3.22 3910 642914878 XP_008190428.1 3797 0.0e+00 PREDICTED: unconventional myosin-Ia [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 P10568 1414 1.1e-154 Unconventional myosin-Ia OS=Bos taurus GN=MYO1A PE=2 SV=1 PF00437//PF06017//PF00612//PF06414//PF00063 Type II/IV secretion system protein//Unconventional myosin tail, actin- and lipid-binding//IQ calmodulin-binding motif//Zeta toxin//Myosin head (motor domain) GO:0006810 transport GO:0005515//GO:0016301//GO:0003774//GO:0005524 protein binding//kinase activity//motor activity//ATP binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.57246 BF_2 28.00 0.36 3536 91089927 XP_973012.1 172 2.6e-09 PREDICTED: uncharacterized protein LOC661778 [Tribolium castaneum]>gi|270013560|gb|EFA10008.1| hypothetical protein TcasGA2_TC012178 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08513 LisH -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57247 BF_2 29.42 3.58 631 642918082 XP_008193932.1 859 1.0e-89 PREDICTED: protein disulfide-isomerase TMX3 [Tribolium castaneum] 847138403 XM_002939615.3 35 9.57037e-07 PREDICTED: Xenopus (Silurana) tropicalis thioredoxin-related transmembrane protein 3 (tmx3), mRNA K09585 TXNDC10 thioredoxin domain-containing protein 10 http://www.genome.jp/dbget-bin/www_bget?ko:K09585 Q6GNG3 429 3.0e-41 Protein disulfide-isomerase TMX3 OS=Xenopus laevis GN=tmx3 PE=2 SV=1 PF01216//PF00659//PF00085 Calsequestrin//POLO box duplicated region//Thioredoxin GO:0045454 cell redox homeostasis GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- KOG0190 Protein disulfide isomerase (prolyl 4-hydroxylase beta subunit) Cluster-8309.57251 BF_2 93.05 5.55 989 270012485 EFA08933.1 488 1.7e-46 hypothetical protein TcasGA2_TC006640 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57253 BF_2 73.49 1.41 2474 642938493 XP_008198006.1 1723 2.6e-189 PREDICTED: nose resistant to fluoxetine protein 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 478 2.5e-46 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF07694 Acyltransferase family//5TMR of 5TMR-LYT GO:0000160//GO:0016310//GO:0071555 phosphorelay signal transduction system//phosphorylation//cell wall organization GO:0000155//GO:0004673//GO:0016747 phosphorelay sensor kinase activity//protein histidine kinase activity//transferase activity, transferring acyl groups other than amino-acyl groups GO:0016021//GO:0009365 integral component of membrane//protein histidine kinase complex -- -- Cluster-8309.57258 BF_2 4.00 0.62 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5726 BF_2 4.73 0.80 534 642921155 XP_975421.2 295 2.1e-24 PREDICTED: nitrilase and fragile histidine triad fusion protein NitFhit [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8VDK1 243 9.4e-20 Nitrilase homolog 1 OS=Mus musculus GN=Nit1 PE=2 SV=2 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG0807 Carbon-nitrogen hydrolase Cluster-8309.57262 BF_2 50.72 1.81 1457 751227278 XP_011167114.1 352 1.4e-30 PREDICTED: uncharacterized protein LOC105200996 isoform X1 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57265 BF_2 6.00 0.87 574 635174379 AHZ64890.1 401 1.2e-36 putative F0F1-type ATP synthase beta subunit [Tetranychus cinnabarinus] 71370859 DQ087459.1 62 8.47483e-22 Sycon lingua ATP synthase beta subunit mRNA, partial cds K02133 ATPeF1B, ATP5B, ATP2 F-type H+-transporting ATPase subunit beta http://www.genome.jp/dbget-bin/www_bget?ko:K02133 P46561 377 2.9e-35 ATP synthase subunit beta, mitochondrial OS=Caenorhabditis elegans GN=atp-2 PE=1 SV=2 PF00306 ATP synthase alpha/beta chain, C terminal domain GO:0015991 ATP hydrolysis coupled proton transport GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0033178 proton-transporting two-sector ATPase complex, catalytic domain KOG1350 F0F1-type ATP synthase, beta subunit Cluster-8309.57266 BF_2 28.27 0.31 4062 642910790 XP_008193412.1 598 1.2e-58 PREDICTED: COMM domain-containing protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9CQ02 306 3.6e-26 COMM domain-containing protein 4 OS=Mus musculus GN=Commd4 PE=2 SV=1 PF10538//PF05434 Immunoreceptor tyrosine-based activation motif//TMEM9 GO:0007165 signal transduction -- -- GO:0016021 integral component of membrane KOG3017 Defense-related protein containing SCP domain Cluster-8309.57267 BF_2 32.90 0.78 2059 -- -- -- -- -- 642918204 XM_008193188.1 112 5.09289e-49 PREDICTED: Tribolium castaneum zinc finger homeobox protein 4 (LOC657717), transcript variant X3, mRNA -- -- -- -- -- -- -- -- PF06203 CCT motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57271 BF_2 15.04 0.47 1628 478249784 ENN70291.1 1109 2.7e-118 hypothetical protein YQE_12803, partial [Dendroctonus ponderosae] -- -- -- -- -- K05039 SLC6A6S solute carrier family 6 (neurotransmitter transporter, GABA) member 6/8/11/12/13 http://www.genome.jp/dbget-bin/www_bget?ko:K05039 Q9VR07 797 1.7e-83 Sodium- and chloride-dependent GABA transporter ine OS=Drosophila melanogaster GN=ine PE=1 SV=1 PF00209//PF04505 Sodium:neurotransmitter symporter family//Interferon-induced transmembrane protein GO:0006812//GO:0006836//GO:0009607 cation transport//neurotransmitter transport//response to biotic stimulus GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3660 Sodium-neurotransmitter symporter Cluster-8309.57273 BF_2 13.00 0.90 889 546685412 ERL94925.1 211 2.0e-14 hypothetical protein D910_12197 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07684 NOTCH protein GO:0007275//GO:0030154//GO:0007219 multicellular organismal development//cell differentiation//Notch signaling pathway -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.57275 BF_2 6.00 0.56 737 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57281 BF_2 90.13 1.86 2313 91087271 XP_975540.1 2035 1.6e-225 PREDICTED: TLD domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZJX5 624 2.7e-63 TLD domain-containing protein 1 OS=Gallus gallus GN=TLDC1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2557 Uncharacterized conserved protein, contains TLDc domain Cluster-8309.57282 BF_2 104.12 1.87 2619 91090272 XP_970617.1 2325 4.3e-259 PREDICTED: nitrogen permease regulator 3-like protein [Tribolium castaneum]>gi|270013442|gb|EFA09890.1| hypothetical protein TcasGA2_TC012039 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VUB4 1321 4.6e-144 Nitrogen permease regulator 3-like protein OS=Drosophila melanogaster GN=CG8783 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3830 Uncharacterized conserved protein Cluster-8309.57283 BF_2 106.87 1.01 4694 270014457 EFA10905.1 248 5.3e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.57284 BF_2 54.82 0.48 5082 270014457 EFA10905.1 248 5.8e-18 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF07776//PF16588 Zinc knuckle//Zinc-finger associated domain (zf-AD)//C2H2 zinc-finger -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.57286 BF_2 35.92 0.48 3434 91078076 XP_971952.1 1434 1.2e-155 PREDICTED: probable proline--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01881 PARS, proS prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01881 Q7L3T8 998 1.7e-106 Probable proline--tRNA ligase, mitochondrial OS=Homo sapiens GN=PARS2 PE=1 SV=1 PF01155//PF00587//PF14895 Hydrogenase/urease nickel incorporation, metallochaperone, hypA//tRNA synthetase class II core domain (G, H, P, S and T)//Protein phosphatase 1 inhibitor GO:0006418//GO:0006464//GO:0010923 tRNA aminoacylation for protein translation//cellular protein modification process//negative regulation of phosphatase activity GO:0000166//GO:0019902//GO:0004812//GO:0005524//GO:0016151 nucleotide binding//phosphatase binding//aminoacyl-tRNA ligase activity//ATP binding//nickel cation binding -- -- KOG2324 Prolyl-tRNA synthetase Cluster-8309.57287 BF_2 45.14 0.38 5282 2072951 AAC51263.1 199 2.9e-12 putative p150 [Homo sapiens] 18042322 AC074239.5 38 1.80642e-07 Homo sapiens BAC clone CTD-2011N5 from 2, complete sequence -- -- -- -- O00370 194 4.5e-13 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57290 BF_2 78.94 0.87 4082 642935255 XP_008197934.1 1689 3.7e-185 PREDICTED: coiled-coil domain-containing protein 142 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04437 RINT-1 / TIP-1 family GO:0048193 Golgi vesicle transport -- -- GO:0005783 endoplasmic reticulum -- -- Cluster-8309.57292 BF_2 94.72 0.95 4463 642928750 XP_008199767.1 2943 0.0e+00 PREDICTED: uncharacterized protein LOC663132 [Tribolium castaneum] 642928749 XM_008201545.1 658 0 PREDICTED: Tribolium castaneum uncharacterized LOC663132 (LOC663132), mRNA -- -- -- -- O60500 211 4.1e-15 Nephrin OS=Homo sapiens GN=NPHS1 PE=1 SV=1 PF05808//PF00001//PF13895 Podoplanin//7 transmembrane receptor (rhodopsin family)//Immunoglobulin domain GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.57293 BF_2 57.00 1.30 2127 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01191 RNA polymerase Rpb5, C-terminal domain GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.57295 BF_2 26.85 0.80 1687 642939169 XP_008200363.1 1187 2.5e-127 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum] -- -- -- -- -- K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8BJA2 646 5.6e-66 Solute carrier family 41 member 1 OS=Mus musculus GN=Slc41a1 PE=2 SV=1 PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- KOG3788 Predicted divalent cation transporter Cluster-8309.57297 BF_2 1.00 12.83 227 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57299 BF_2 7.73 0.39 1112 270006684 EFA03132.1 744 3.9e-76 hypothetical protein TcasGA2_TC013044 [Tribolium castaneum] 642924851 XM_008195844.1 184 2.56407e-89 PREDICTED: Tribolium castaneum nuclear migration protein nudC (LOC656519), mRNA -- -- -- -- Q9Y266 550 5.0e-55 Nuclear migration protein nudC OS=Homo sapiens GN=NUDC PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2265 Nuclear distribution protein NUDC Cluster-8309.57301 BF_2 79.83 1.18 3111 91081997 XP_969187.1 655 2.3e-65 PREDICTED: pre-mRNA 3' end processing protein WDR33 [Tribolium castaneum]>gi|270007376|gb|EFA03824.1| hypothetical protein TcasGA2_TC013939 [Tribolium castaneum] 556962117 XM_005991191.1 60 6.23884e-20 PREDICTED: Latimeria chalumnae WD repeat domain 33 (WDR33), mRNA K15542 PFS2 polyadenylation factor subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15542 Q9C0J8 558 1.6e-55 pre-mRNA 3' end processing protein WDR33 OS=Homo sapiens GN=WDR33 PE=1 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0284 Polyadenylation factor I complex, subunit PFS2 Cluster-8309.57307 BF_2 89.39 4.23 1171 91083169 XP_972121.1 523 1.7e-50 PREDICTED: uncharacterized protein LOC660825 [Tribolium castaneum]>gi|270007697|gb|EFA04145.1| hypothetical protein TcasGA2_TC014389 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.57308 BF_2 76.26 3.30 1253 91083169 XP_972121.1 523 1.8e-50 PREDICTED: uncharacterized protein LOC660825 [Tribolium castaneum]>gi|270007697|gb|EFA04145.1| hypothetical protein TcasGA2_TC014389 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00583//PF13508 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080 N-acetyltransferase activity -- -- -- -- Cluster-8309.57315 BF_2 75.56 1.57 2301 642932618 XP_008196922.1 1605 1.2e-175 PREDICTED: glucose dehydrogenase [FAD, quinone]-like isoform X1 [Tribolium castaneum]>gi|270012387|gb|EFA08835.1| hypothetical protein TcasGA2_TC006533 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18173 722 1.2e-74 Glucose dehydrogenase [FAD, quinone] OS=Drosophila melanogaster GN=Gld PE=3 SV=3 PF01266//PF07992//PF05834//PF00732//PF05199//PF02254 FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0016117//GO:0055114//GO:0006813 carotenoid biosynthetic process//oxidation-reduction process//potassium ion transport GO:0050660//GO:0016614//GO:0016705//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on CH-OH group of donors//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity -- -- -- -- Cluster-8309.57316 BF_2 13.96 0.41 1704 478254983 ENN75216.1 306 3.6e-25 hypothetical protein YQE_08226, partial [Dendroctonus ponderosae]>gi|546678564|gb|ERL89153.1| hypothetical protein D910_06529 [Dendroctonus ponderosae] -- -- -- -- -- K19347 SUN1_2 SUN domain-containing protein 1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K19347 Q9D666 175 2.3e-11 SUN domain-containing protein 1 OS=Mus musculus GN=Sun1 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57318 BF_2 10.16 0.31 1648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57320 BF_2 38.00 2.95 826 795169273 XP_011798349.1 1349 2.0e-146 PREDICTED: elongation factor 1-alpha 1 [Colobus angolensis palliatus] 694986412 XM_001138897.4 731 0 PREDICTED: Pan troglodytes putative elongation factor 1-alpha-like 3 (LOC739210), mRNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q5R4R8 1349 8.3e-148 Elongation factor 1-alpha 1 OS=Pongo abelii GN=EEF1A1 PE=2 SV=2 PF01926//PF00503 50S ribosome-binding GTPase//G-protein alpha subunit GO:0007186//GO:0007165 G-protein coupled receptor signaling pathway//signal transduction GO:0003924//GO:0031683//GO:0019001//GO:0004871//GO:0005525 GTPase activity//G-protein beta/gamma-subunit complex binding//guanyl nucleotide binding//signal transducer activity//GTP binding -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.57321 BF_2 7.00 15.50 281 564344879 XP_006235797.1 388 1.9e-35 PREDICTED: elongation factor 1-alpha 2 isoform X2 [Rattus norvegicus] 675785536 XR_608502.1 281 7.06148e-144 PREDICTED: Pan paniscus elongation factor 1-alpha 1 pseudogene (LOC100985170), misc_RNA K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 Q71V39 381 4.9e-36 Elongation factor 1-alpha 2 OS=Oryctolagus cuniculus GN=EEF1A2 PE=1 SV=1 PF01580//PF06431//PF00503 FtsK/SpoIIIE family//Polyomavirus large T antigen C-terminus//G-protein alpha subunit GO:0006260//GO:0007186//GO:0007165 DNA replication//G-protein coupled receptor signaling pathway//signal transduction GO:0004871//GO:0019001//GO:0000166//GO:0003677//GO:0031683//GO:0005524//GO:0003924 signal transducer activity//guanyl nucleotide binding//nucleotide binding//DNA binding//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity -- -- KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-8309.57339 BF_2 175.00 10.91 958 91093713 XP_967373.1 1074 1.8e-114 PREDICTED: mitochondrial ubiquitin ligase activator of NFKB 1 [Tribolium castaneum]>gi|270013001|gb|EFA09449.1| hypothetical protein TcasGA2_TC010664 [Tribolium castaneum] -- -- -- -- -- K15688 MUL1 E3 ubiquitin-protein ligase MUL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15688 Q969V5 333 6.2e-30 Mitochondrial ubiquitin ligase activator of NFKB 1 OS=Homo sapiens GN=MUL1 PE=1 SV=1 PF12483 E3 Ubiquitin ligase GO:0016567//GO:0007005 protein ubiquitination//mitochondrion organization GO:0046872//GO:0004842//GO:0016881//GO:0008270 metal ion binding//ubiquitin-protein transferase activity//acid-amino acid ligase activity//zinc ion binding -- -- -- -- Cluster-8309.57340 BF_2 119.81 1.20 4459 357604009 EHJ64005.1 1337 2.7e-144 hypothetical protein KGM_07794 [Danaus plexippus] 815896313 XM_003485235.2 198 1.73459e-96 PREDICTED: Bombus impatiens cytoplasmic tRNA 2-thiolation protein 1 (LOC100747993), mRNA K14168 CTU1, NCS6 cytoplasmic tRNA 2-thiolation protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14168 B4KLL0 1292 1.8e-140 Cytoplasmic tRNA 2-thiolation protein 1 OS=Drosophila mojavensis GN=GI19452 PE=3 SV=1 PF13639//PF10288//PF14634 Ring finger domain//Cytoplasmic tRNA 2-thiolation protein 2//zinc-RING finger domain GO:0002098//GO:0034227 tRNA wobble uridine modification//tRNA thio-modification GO:0005515//GO:0000049//GO:0008270 protein binding//tRNA binding//zinc ion binding -- -- KOG2840 Uncharacterized conserved protein with similarity to predicted ATPase of the PP-loop superfamily Cluster-8309.57362 BF_2 8.83 0.43 1142 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57369 BF_2 29.00 1.29 1229 642933218 XP_008197312.1 579 5.8e-57 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 352 5.0e-32 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57371 BF_2 20.00 0.53 1852 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57375 BF_2 21.15 0.36 2729 642925278 XP_008194489.1 1289 6.0e-139 PREDICTED: PAX-interacting protein 1 [Tribolium castaneum]>gi|270009278|gb|EFA05726.1| hypothetical protein TcasGA2_TC015410 [Tribolium castaneum] -- -- -- -- -- K14972 PAXIP1, PTIP PAX-interacting protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K14972 Q6ZW49 393 2.0e-36 PAX-interacting protein 1 OS=Homo sapiens GN=PAXIP1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.57378 BF_2 7.42 0.38 1094 260832614 XP_002611252.1 172 8.1e-10 hypothetical protein BRAFLDRAFT_119658 [Branchiostoma floridae]>gi|229296623|gb|EEN67262.1| hypothetical protein BRAFLDRAFT_119658 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9PVG3 147 2.6e-08 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF02150//PF13465//PF00096 RNA polymerases M/15 Kd subunit//Zinc-finger double domain//Zinc finger, C2H2 type GO:0006206//GO:0006351//GO:0006144 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process GO:0003677//GO:0003899//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.5738 BF_2 1.00 0.34 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57380 BF_2 51.89 0.63 3724 642918712 XP_008191550.1 1452 1.0e-157 PREDICTED: phospholipase D2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 P70496 674 7.0e-69 Phospholipase D1 OS=Rattus norvegicus GN=Pld1 PE=1 SV=3 PF02399//PF00614//PF00787 Origin of replication binding protein//Phospholipase D Active site motif//PX domain GO:0006260 DNA replication GO:0035091//GO:0003688//GO:0005524//GO:0003824 phosphatidylinositol binding//DNA replication origin binding//ATP binding//catalytic activity GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.57385 BF_2 20.13 1.12 1039 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57387 BF_2 16.30 0.53 1563 270015560 EFA12008.1 767 1.2e-78 hypothetical protein TcasGA2_TC016136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57392 BF_2 391.98 15.75 1328 91087565 XP_971161.1 1263 3.0e-136 PREDICTED: RNA 3'-terminal phosphate cyclase [Tribolium castaneum]>gi|642930249|ref|XP_008196316.1| PREDICTED: RNA 3'-terminal phosphate cyclase [Tribolium castaneum] -- -- -- -- -- K01974 RTCA, rtcA RNA 3'-terminal phosphate cyclase (ATP) http://www.genome.jp/dbget-bin/www_bget?ko:K01974 Q9D7H3 896 4.5e-95 RNA 3'-terminal phosphate cyclase OS=Mus musculus GN=RtcA PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3980 RNA 3'-terminal phosphate cyclase Cluster-8309.57393 BF_2 21.41 0.52 2020 625273551 XP_007628350.1 527 1.0e-50 PREDICTED: zinc finger protein 14-like isoform X4 [Cricetulus griseus] -- -- -- -- -- -- -- -- -- Q5XIU2 811 4.9e-85 Zinc finger protein 143 OS=Rattus norvegicus GN=Znf143 PE=2 SV=2 PF13912//PF00962//PF13465//PF00096 C2H2-type zinc finger//Adenosine/AMP deaminase//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0019239//GO:0046872 deaminase activity//metal ion binding -- -- -- -- Cluster-8309.57395 BF_2 35.00 134.94 261 431902819 ELK09034.1 155 1.8e-08 hypothetical protein PAL_GLEAN10008241 [Pteropus alecto] 551865959 HG501988.1 261 8.51761e-133 TPA: Homo sapiens long non-coding RNA OTTHUMT00000467764.1 (RP11-331F9.10 gene), lincRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57397 BF_2 51.51 0.63 3732 642923482 XP_008193528.1 402 5.9e-36 PREDICTED: hyccin [Tribolium castaneum] 642923486 XM_008195309.1 166 8.91077e-79 PREDICTED: Tribolium castaneum RNA binding protein fox-1 homolog 3 (LOC655682), transcript variant X3, mRNA K14946 RBFOX, FOX RNA binding protein fox-1 http://www.genome.jp/dbget-bin/www_bget?ko:K14946 Q0VD23 234 7.3e-18 RNA binding protein fox-1 homolog 3 OS=Bos taurus GN=RBFOX3 PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0125 Ataxin 2-binding protein (RRM superfamily) Cluster-8309.57404 BF_2 118.70 1.58 3429 270006660 EFA03108.1 826 3.7e-85 hypothetical protein TcasGA2_TC013018 [Tribolium castaneum] 805796309 XM_012287860.1 44 5.39751e-11 PREDICTED: Megachile rotundata SUN domain-containing ossification factor (LOC100876839), transcript variant X4, mRNA -- -- -- -- Q710E6 563 4.8e-56 SUN domain-containing ossification factor OS=Rattus norvegicus GN=Suco PE=2 SV=1 PF15281//PF03739//PF11629 Consortin C-terminus//Predicted permease YjgP/YjgQ family//C terminal SARAH domain of Mst1 GO:0009069//GO:0042998//GO:0016310 serine family amino acid metabolic process//positive regulation of Golgi to plasma membrane protein transport//phosphorylation GO:0071253//GO:0004674 connexin binding//protein serine/threonine kinase activity GO:0005802//GO:0016021 trans-Golgi network//integral component of membrane KOG1396 Uncharacterized conserved protein Cluster-8309.57408 BF_2 15.00 0.72 1159 642918514 XP_008191505.1 183 4.5e-11 PREDICTED: zinc finger protein Xfin-like [Tribolium castaneum]>gi|270003216|gb|EEZ99663.1| hypothetical protein TcasGA2_TC002420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57412 BF_2 134.52 0.65 8991 270007727 EFA04175.1 2353 8.3e-262 hypothetical protein TcasGA2_TC014424 [Tribolium castaneum] 642923781 XM_008195660.1 114 1.74062e-49 PREDICTED: Tribolium castaneum regulating synaptic membrane exocytosis protein 2 (LOC663311), mRNA K15297 RIMS2, RIM2 regulating synaptic membrane exocytosis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K15297 Q9UQ26 647 2.3e-65 Regulating synaptic membrane exocytosis protein 2 OS=Homo sapiens GN=RIMS2 PE=1 SV=2 PF00168//PF00595 C2 domain//PDZ domain (Also known as DHR or GLGF) -- -- GO:0005515 protein binding -- -- KOG2060 Rab3 effector RIM1 and related proteins, contain PDZ and C2 domains Cluster-8309.57413 BF_2 96.03 1.71 2643 270001539 EEZ97986.1 2008 2.5e-222 hypothetical protein TcasGA2_TC000381 [Tribolium castaneum] 642914388 XM_008203435.1 292 5.69656e-149 PREDICTED: Tribolium castaneum STE20-like serine/threonine-protein kinase (LOC663345), mRNA K12838 PUF60 poly(U)-binding-splicing factor PUF60 http://www.genome.jp/dbget-bin/www_bget?ko:K12838 Q8T6B9 1089 3.7e-117 Poly(U)-binding-splicing factor half pint OS=Drosophila melanogaster GN=pUf68 PE=1 SV=2 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0003723 nucleic acid binding//RNA binding -- -- KOG0124 Polypyrimidine tract-binding protein PUF60 (RRM superfamily) Cluster-8309.57416 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57423 BF_2 186.56 3.10 2807 642921802 XP_008199325.1 715 2.2e-72 PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum]>gi|642921804|ref|XP_008199326.1| PREDICTED: uncharacterized protein LOC103314630 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9R007 146 8.8e-08 C-type lectin domain family 5 member A OS=Mus musculus GN=Clec5a PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57427 BF_2 4.00 0.75 510 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57429 BF_2 212.00 15.29 867 642917818 XP_008191298.1 198 6.2e-13 PREDICTED: uncharacterized protein LOC103312446 [Tribolium castaneum]>gi|642917820|ref|XP_008191299.1| PREDICTED: uncharacterized protein LOC103312446 [Tribolium castaneum]>gi|642917822|ref|XP_008191300.1| PREDICTED: uncharacterized protein LOC103312446 [Tribolium castaneum]>gi|270003354|gb|EEZ99801.1| hypothetical protein TcasGA2_TC002581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5743 BF_2 8.59 1.46 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57430 BF_2 7.91 0.45 1026 675372920 KFM65822.1 148 4.6e-07 THAP domain-containing protein 1, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.57432 BF_2 4.00 0.34 773 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03604 DNA directed RNA polymerase, 7 kDa subunit GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus -- -- Cluster-8309.57433 BF_2 214.80 5.86 1821 642918767 XP_008191575.1 1237 4.3e-133 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9Y251 732 6.4e-76 Heparanase OS=Homo sapiens GN=HPSE PE=1 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.57443 BF_2 134.17 0.47 12196 546678376 ERL89009.1 14606 0.0e+00 hypothetical protein D910_06387 [Dendroctonus ponderosae] 861437320 XM_013072408.1 160 6.34346e-75 PREDICTED: Heterocephalus glaber dynein, axonemal, heavy chain 5 (Dnah5), mRNA K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 Q96JB1 10416 0.0e+00 Dynein heavy chain 8, axonemal OS=Homo sapiens GN=DNAH8 PE=1 SV=2 PF11112//PF09520//PF07728//PF00004//PF03028 Pyocin activator protein PrtN//Type II restriction endonuclease, TdeIII//AAA domain (dynein-related subfamily)//ATPase family associated with various cellular activities (AAA)//Dynein heavy chain and region D6 of dynein motor GO:0007018//GO:0006308//GO:0006355//GO:0007017//GO:0009307 microtubule-based movement//DNA catabolic process//regulation of transcription, DNA-templated//microtubule-based process//DNA restriction-modification system GO:0003777//GO:0005524//GO:0003677//GO:0009036//GO:0016887 microtubule motor activity//ATP binding//DNA binding//Type II site-specific deoxyribonuclease activity//ATPase activity GO:0005874//GO:0030286//GO:0009359 microtubule//dynein complex//Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.57451 BF_2 5.35 0.87 545 642933032 XP_008197237.1 243 2.3e-18 PREDICTED: serine/threonine-protein kinase unc-51 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57456 BF_2 3.00 1.39 375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57459 BF_2 151.32 1.80 3804 91079364 XP_970368.1 4390 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917122|ref|XP_008191123.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917124|ref|XP_008191125.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|270004364|gb|EFA00812.1| hypothetical protein TcasGA2_TC003699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0P5W1 1514 2.8e-166 Vacuolar protein sorting-associated protein 8 homolog OS=Mus musculus GN=Vps8 PE=2 SV=1 PF12678//PF02148//PF17123//PF14634//PF00628//PF17122//PF13639//PF00637//PF13374 RING-H2 zinc finger//Zn-finger in ubiquitin-hydrolases and other protein//RING-like zinc finger//zinc-RING finger domain//PHD-finger//Zinc-finger//Ring finger domain//Region in Clathrin and VPS//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005622 intracellular KOG2079 Vacuolar assembly/sorting protein VPS8 Cluster-8309.57460 BF_2 121.73 2.79 2112 642937669 XP_008198894.1 1444 5.0e-157 PREDICTED: uncharacterized protein LOC103314480 [Tribolium castaneum]>gi|270001142|gb|EEZ97589.1| hypothetical protein TcasGA2_TC011452 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02119 Flagellar P-ring protein GO:0071973 bacterial-type flagellum-dependent cell motility GO:0005198//GO:0016772 structural molecule activity//transferase activity, transferring phosphorus-containing groups GO:0030288//GO:0009428 outer membrane-bounded periplasmic space//bacterial-type flagellum basal body, distal rod, P ring -- -- Cluster-8309.57466 BF_2 10.00 0.34 1509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57467 BF_2 26.56 0.49 2556 91085445 XP_966423.1 602 2.6e-59 PREDICTED: peptidyl-tRNA hydrolase 2, mitochondrial [Tribolium castaneum]>gi|270009178|gb|EFA05626.1| hypothetical protein TcasGA2_TC015834 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 Q3ZBL5 274 1.2e-22 Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus GN=PTRH2 PE=2 SV=1 PF04434//PF01981//PF09243 SWIM zinc finger//Peptidyl-tRNA hydrolase PTH2//Mitochondrial small ribosomal subunit Rsm22 GO:0006412 translation GO:0008270//GO:0008168//GO:0004045 zinc ion binding//methyltransferase activity//aminoacyl-tRNA hydrolase activity -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.57468 BF_2 68.48 3.15 1196 761901546 XP_011404925.1 340 2.9e-29 PREDICTED: uncharacterized protein LOC100639010 [Amphimedon queenslandica] -- -- -- -- -- -- -- -- -- Q1RK13 304 1.8e-26 Putative ankyrin repeat protein RBE_0220 OS=Rickettsia bellii (strain RML369-C) GN=RBE_0220 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57469 BF_2 27.95 0.82 1715 642920753 XP_008192548.1 1430 1.7e-155 PREDICTED: probable asparagine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270005193|gb|EFA01641.1| hypothetical protein TcasGA2_TC007211 [Tribolium castaneum] -- -- -- -- -- K01893 NARS, asnS asparaginyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01893 Q96I59 1064 1.9e-114 Probable asparagine--tRNA ligase, mitochondrial OS=Homo sapiens GN=NARS2 PE=1 SV=3 PF00587//PF00152//PF01409 tRNA synthetase class II core domain (G, H, P, S and T)//tRNA synthetases class II (D, K and N)//tRNA synthetases class II core domain (F) GO:0043039//GO:0006418 tRNA aminoacylation//tRNA aminoacylation for protein translation GO:0000049//GO:0004812//GO:0000166//GO:0005524 tRNA binding//aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG0554 Asparaginyl-tRNA synthetase (mitochondrial) Cluster-8309.57470 BF_2 6.60 0.81 629 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57472 BF_2 38.60 2.82 860 642926280 XP_008194858.1 524 9.7e-51 PREDICTED: uncharacterized protein LOC103313420 isoform X1 [Tribolium castaneum]>gi|270008508|gb|EFA04956.1| hypothetical protein TcasGA2_TC015025 [Tribolium castaneum] 749773866 XM_011143969.1 81 3.55366e-32 PREDICTED: Harpegnathos saltator uncharacterized LOC105184868 (LOC105184868), transcript variant X1, mRNA K10885 XRCC5, KU80, G22P2 ATP-dependent DNA helicase 2 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10885 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57475 BF_2 10.50 1.04 708 270004586 EFA01034.1 396 5.5e-36 hypothetical protein TcasGA2_TC003950 [Tribolium castaneum] 194759499 XM_001961949.1 37 8.35258e-08 Drosophila ananassae GF14663 (Dana\GF14663), mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8NB50 336 2.1e-30 Zinc finger protein 62 homolog OS=Homo sapiens GN=ZFP62 PE=2 SV=3 PF13465//PF00096//PF13912//PF01363 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//FYVE zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57476 BF_2 4.00 0.37 745 270004588 EFA01036.1 244 2.5e-18 hypothetical protein TcasGA2_TC003952 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C827 211 6.8e-16 Zinc finger protein 62 OS=Mus musculus GN=Zfp62 PE=2 SV=1 PF00096//PF00130//PF13465//PF00412//PF04810//PF01363//PF13912//PF01428 Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Zinc-finger double domain//LIM domain//Sec23/Sec24 zinc finger//FYVE zinc finger//C2H2-type zinc finger//AN1-like Zinc finger GO:0006886//GO:0006888//GO:0035556 intracellular protein transport//ER to Golgi vesicle-mediated transport//intracellular signal transduction GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.57481 BF_2 68.14 3.55 1090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57483 BF_2 12.40 0.32 1912 189234350 XP_973716.2 1510 1.0e-164 PREDICTED: probable cysteine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q8BYM8 944 1.8e-100 Probable cysteine--tRNA ligase, mitochondrial OS=Mus musculus GN=Cars2 PE=2 SV=2 PF16954//PF09190//PF00133//PF09334 Haem-transporter, endosomal/lysosomal, haem-responsive gene//DALR domain//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0006423//GO:0006418//GO:0015886//GO:0006534 cysteinyl-tRNA aminoacylation//tRNA aminoacylation for protein translation//heme transport//cysteine metabolic process GO:0004817//GO:0000166//GO:0004812//GO:0005524//GO:0015232 cysteine-tRNA ligase activity//nucleotide binding//aminoacyl-tRNA ligase activity//ATP binding//heme transporter activity GO:0005737 cytoplasm KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.57484 BF_2 14.44 0.35 1998 270001919 EEZ98366.1 1469 5.9e-160 hypothetical protein TcasGA2_TC000823 [Tribolium castaneum] -- -- -- -- -- K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q8BYM8 905 6.1e-96 Probable cysteine--tRNA ligase, mitochondrial OS=Mus musculus GN=Cars2 PE=2 SV=2 PF16954//PF00579//PF09190//PF00133//PF09334 Haem-transporter, endosomal/lysosomal, haem-responsive gene//tRNA synthetases class I (W and Y)//DALR domain//tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M) GO:0006534//GO:0015886//GO:0006418//GO:0006423 cysteine metabolic process//heme transport//tRNA aminoacylation for protein translation//cysteinyl-tRNA aminoacylation GO:0015232//GO:0005524//GO:0004812//GO:0004817//GO:0000166 heme transporter activity//ATP binding//aminoacyl-tRNA ligase activity//cysteine-tRNA ligase activity//nucleotide binding GO:0005737 cytoplasm KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.57485 BF_2 10.16 0.36 1478 189234350 XP_973716.2 1074 2.8e-114 PREDICTED: probable cysteine--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01883 CARS, cysS cysteinyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01883 Q6PA41 632 2.0e-64 Probable cysteine--tRNA ligase, mitochondrial OS=Xenopus laevis GN=cars2 PE=2 SV=1 PF00133//PF09334//PF09190//PF16954 tRNA synthetases class I (I, L, M and V)//tRNA synthetases class I (M)//DALR domain//Haem-transporter, endosomal/lysosomal, haem-responsive gene GO:0006418//GO:0006423//GO:0006534//GO:0015886 tRNA aminoacylation for protein translation//cysteinyl-tRNA aminoacylation//cysteine metabolic process//heme transport GO:0004812//GO:0000166//GO:0004817//GO:0005524//GO:0015232 aminoacyl-tRNA ligase activity//nucleotide binding//cysteine-tRNA ligase activity//ATP binding//heme transporter activity GO:0005737 cytoplasm KOG2007 Cysteinyl-tRNA synthetase Cluster-8309.57486 BF_2 19.83 0.45 2140 270001079 EEZ97526.1 1116 5.4e-119 hypothetical protein TcasGA2_TC011371 [Tribolium castaneum] -- -- -- -- -- K13499 CHSY chondroitin sulfate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K13499 Q86X52 775 7.8e-81 Chondroitin sulfate synthase 1 OS=Homo sapiens GN=CHSY1 PE=1 SV=3 PF05679 Chondroitin N-acetylgalactosaminyltransferase -- -- GO:0008376 acetylgalactosaminyltransferase activity GO:0032580 Golgi cisterna membrane KOG3588 Chondroitin synthase 1 Cluster-8309.57487 BF_2 101.00 2.25 2169 642929096 XP_974387.2 1754 5.8e-193 PREDICTED: eyes absent homolog 2 [Tribolium castaneum] -- -- -- -- -- K15616 EYA1 eyes absent homolog 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15616 Q99502 1125 2.1e-121 Eyes absent homolog 1 OS=Homo sapiens GN=EYA1 PE=1 SV=2 PF12906//PF12678//PF00097//PF13639 RING-variant domain//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger)//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- KOG3107 Predicted haloacid dehalogenase-like hydrolase (eyes absent) Cluster-8309.57490 BF_2 6.39 0.57 752 91088597 XP_973576.1 415 3.7e-38 PREDICTED: ketimine reductase mu-crystallin [Tribolium castaneum]>gi|270012255|gb|EFA08703.1| hypothetical protein TcasGA2_TC006374 [Tribolium castaneum] -- -- -- -- -- K18258 CRYM thiomorpholine-carboxylate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K18258 Q14894 266 2.9e-22 Ketimine reductase mu-crystallin OS=Homo sapiens GN=CRYM PE=1 SV=1 PF02882 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GO:0046487//GO:0009396//GO:0055114 glyoxylate metabolic process//folic acid-containing compound biosynthetic process//oxidation-reduction process GO:0003824//GO:0004488 catalytic activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity -- -- KOG3007 Mu-crystallin Cluster-8309.57493 BF_2 18.00 0.51 1761 391334509 XP_003741646.1 635 2.7e-63 PREDICTED: uncharacterized protein LOC100899549 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03882 KicB killing factor GO:0007059//GO:0006260 chromosome segregation//DNA replication GO:0005509 calcium ion binding GO:0005737 cytoplasm -- -- Cluster-8309.57495 BF_2 24.00 0.78 1574 146182859 XP_001025435.2 145 1.6e-06 CnjB protein [Tetrahymena thermophila SB210]>gi|146143687|gb|EAS05190.2| CnjB protein [Tetrahymena thermophila SB210] -- -- -- -- -- -- -- -- -- Q8WW36 130 3.5e-06 Zinc finger CCHC domain-containing protein 13 OS=Homo sapiens GN=ZCCHC13 PE=1 SV=1 PF00098 Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG4400 E3 ubiquitin ligase interacting with arginine methyltransferase Cluster-8309.57499 BF_2 39.56 0.47 3809 270015258 EFA11706.1 1215 3.2e-130 hypothetical protein TcasGA2_TC001793 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10394 328 9.4e-29 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.57501 BF_2 40.00 0.66 2814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57504 BF_2 11.00 1.69 560 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57506 BF_2 151.00 2.61 2711 642918511 XP_008191503.1 368 3.7e-32 PREDICTED: uncharacterized protein LOC103312504 [Tribolium castaneum]>gi|270003218|gb|EEZ99665.1| hypothetical protein TcasGA2_TC002422 [Tribolium castaneum] -- -- -- -- -- K16453 CCP110, CEP110 centrosomal protein CEP110 http://www.genome.jp/dbget-bin/www_bget?ko:K16453 O43303 155 7.7e-09 Centriolar coiled-coil protein of 110 kDa OS=Homo sapiens GN=CCP110 PE=1 SV=3 PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57507 BF_2 16.00 1.31 800 642925861 XP_008190588.1 863 4.4e-90 PREDICTED: osmotic avoidance abnormal protein 3 [Tribolium castaneum] -- -- -- -- -- K10394 KIF3_17 kinesin family member 3/17 http://www.genome.jp/dbget-bin/www_bget?ko:K10394 Q9P2E2 637 2.9e-65 Kinesin-like protein KIF17 OS=Homo sapiens GN=KIF17 PE=2 SV=3 PF08477//PF00225 Ras of Complex, Roc, domain of DAPkinase//Kinesin motor domain GO:0007018//GO:0007017//GO:0007264 microtubule-based movement//microtubule-based process//small GTPase mediated signal transduction GO:0005524//GO:0003777//GO:0005525//GO:0008017 ATP binding//microtubule motor activity//GTP binding//microtubule binding GO:0005874//GO:0045298 microtubule//tubulin complex KOG4280 Kinesin-like protein Cluster-8309.57509 BF_2 11.74 0.35 1709 241627626 XP_002408070.1 701 5.8e-71 RNA-binding protein musashi, putative [Ixodes scapularis]>gi|215501115|gb|EEC10609.1| RNA-binding protein musashi, putative [Ixodes scapularis] -- -- -- -- -- K13044 HNRNPABD heterogeneous nuclear ribonucleoprotein A/B/D http://www.genome.jp/dbget-bin/www_bget?ko:K13044 Q08473 508 5.7e-50 RNA-binding protein squid OS=Drosophila melanogaster GN=sqd PE=1 SV=3 PF08777//PF16367//PF00076 RNA binding motif//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003723//GO:0097159//GO:0003676//GO:1901363 RNA binding//organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG4205 RNA-binding protein musashi/mRNA cleavage and polyadenylation factor I complex, subunit HRP1 Cluster-8309.57511 BF_2 5.00 1.80 402 470266136 XP_004361693.1 497 6.1e-48 Putative Ligase [Dictyostelium fasciculatum]>gi|328875478|gb|EGG23842.1| Putative Ligase [Dictyostelium fasciculatum] 568870193 XM_006488229.1 258 6.41358e-131 PREDICTED: Citrus sinensis ubiquitin-conjugating enzyme E2 7-like (LOC102607489), mRNA K10575 UBE2G1, UBC7 ubiquitin-conjugating enzyme E2 G1 http://www.genome.jp/dbget-bin/www_bget?ko:K10575 Q42540 618 2.3e-63 Ubiquitin-conjugating enzyme E2 7 OS=Arabidopsis thaliana GN=UBC7 PE=2 SV=1 PF05773 RWD domain -- -- GO:0005515//GO:0016874//GO:0000166 protein binding//ligase activity//nucleotide binding -- -- KOG0425 Ubiquitin-protein ligase Cluster-8309.57512 BF_2 13.00 3.74 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57514 BF_2 30.00 1.32 1237 61652776 AAX47960.1 524 1.4e-50 prophenoloxidase activating factor serine proteinase [Scylla serrata] -- -- -- -- -- K08670 ST14, PRSS14 suppressor of tumorigenicity protein 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08670 Q6SA95 371 3.1e-34 Coagulation factor IX OS=Felis catus GN=F9 PE=3 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.57518 BF_2 302.69 2.84 4740 642926758 XP_008195001.1 1018 2.8e-107 PREDICTED: gastrula zinc finger protein XlCGF52.1-like [Tribolium castaneum]>gi|270008400|gb|EFA04848.1| hypothetical protein TcasGA2_TC014900 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 464 2.0e-44 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF12937//PF13465//PF00096//PF00646//PF07776//PF15966//PF13912 F-box-like//Zinc-finger double domain//Zinc finger, C2H2 type//F-box domain//Zinc-finger associated domain (zf-AD)//F-box//C2H2-type zinc finger -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.57520 BF_2 138.61 5.11 1422 478257453 ENN77609.1 221 2.2e-15 hypothetical protein YQE_05904, partial [Dendroctonus ponderosae]>gi|546679848|gb|ERL90236.1| hypothetical protein D910_07589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57523 BF_2 16.00 0.32 2373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57524 BF_2 20.00 0.37 2576 270010125 EFA06573.1 207 1.7e-13 hypothetical protein TcasGA2_TC009484 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0019835//GO:0009405 cytolysis//pathogenesis -- -- GO:0019867 outer membrane -- -- Cluster-8309.57529 BF_2 16.41 0.78 1162 642933039 XP_008197239.1 756 1.6e-77 PREDICTED: neo-calmodulin-like isoform X1 [Tribolium castaneum] 642933042 XM_966204.3 205 5.67888e-101 PREDICTED: Tribolium castaneum neo-calmodulin-like (LOC659938), transcript variant X3, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 P02594 345 3.1e-31 Calmodulin OS=Electrophorus electricus GN=calm PE=2 SV=2 PF13833//PF10591//PF13405//PF00036//PF13499//PF13202//PF12763 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF hand//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand GO:0007165 signal transduction GO:0005515//GO:0005509 protein binding//calcium ion binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.5753 BF_2 13.25 0.42 1617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02536 mTERF GO:0006355 regulation of transcription, DNA-templated GO:0003690 double-stranded DNA binding GO:0005739 mitochondrion -- -- Cluster-8309.57530 BF_2 291.00 6.60 2131 198427319 XP_002121818.1 333 3.4e-28 PREDICTED: aprataxin and PNK-like factor [Ciona intestinalis] -- -- -- -- -- K13295 APLF aprataxin and PNK-like factor http://www.genome.jp/dbget-bin/www_bget?ko:K13295 Q8IW19 230 1.2e-17 Aprataxin and PNK-like factor OS=Homo sapiens GN=APLF PE=1 SV=1 PF00822//PF00498 PMP-22/EMP/MP20/Claudin family//FHA domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.57537 BF_2 40.95 0.32 5679 270013163 EFA09611.1 913 5.0e-95 hypothetical protein TcasGA2_TC011732 [Tribolium castaneum] 194880702 XM_001974468.1 91 6.69828e-37 Drosophila erecta GG21059 (Dere\GG21059), mRNA -- -- -- -- -- -- -- -- PF08022//PF00041//PF16656 FAD-binding domain//Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0055114//GO:0019497 riboflavin metabolic process//oxidation-reduction process//hexachlorocyclohexane metabolic process GO:0003993//GO:0016491//GO:0005515//GO:0046872 acid phosphatase activity//oxidoreductase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.5754 BF_2 10.63 0.35 1569 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02536 mTERF GO:0006355 regulation of transcription, DNA-templated GO:0003690 double-stranded DNA binding GO:0005739 mitochondrion -- -- Cluster-8309.57543 BF_2 77.63 1.63 2276 780633762 XP_011686120.1 148 1.0e-06 PREDICTED: uncharacterized protein LOC105448935 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08468 Methyltransferase small domain N-terminal GO:0006364//GO:0000154//GO:0006396 rRNA processing//rRNA modification//RNA processing GO:0008990 rRNA (guanine-N2-)-methyltransferase activity -- -- -- -- Cluster-8309.57544 BF_2 23.74 0.35 3121 28435510 AAL78163.1 2756 5.4e-309 phosphoenolpyruvate-carboxykinase [Neohelice granulata] 28435509 AY074922.1 1172 0 Chasmagnathus granulata phosphoenolpyruvate-carboxykinase (PEPCK) mRNA, complete cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 Q16822 2273 2.2e-254 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens GN=PCK2 PE=1 SV=3 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.57545 BF_2 122.26 2.44 2385 28435510 AAL78163.1 2756 4.1e-309 phosphoenolpyruvate-carboxykinase [Neohelice granulata] 28435509 AY074922.1 1187 0 Chasmagnathus granulata phosphoenolpyruvate-carboxykinase (PEPCK) mRNA, complete cds K01596 E4.1.1.32, pckA, PEPCK phosphoenolpyruvate carboxykinase (GTP) http://www.genome.jp/dbget-bin/www_bget?ko:K01596 Q16822 2273 1.7e-254 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial OS=Homo sapiens GN=PCK2 PE=1 SV=3 PF00821 Phosphoenolpyruvate carboxykinase GO:0006094 gluconeogenesis GO:0005525//GO:0004611 GTP binding//phosphoenolpyruvate carboxykinase activity -- -- KOG3749 Phosphoenolpyruvate carboxykinase Cluster-8309.57547 BF_2 104.71 2.20 2277 642936094 XP_008198300.1 1991 2.0e-220 PREDICTED: PR domain zinc finger protein 10-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B4F6U4 394 1.3e-36 PR domain zinc finger protein 10 OS=Xenopus tropicalis GN=prdm10 PE=2 SV=1 PF00096//PF13465//PF00856//PF13912//PF02226 Zinc finger, C2H2 type//Zinc-finger double domain//SET domain//C2H2-type zinc finger//Picornavirus coat protein (VP4) -- -- GO:0005515//GO:0046872//GO:0005198 protein binding//metal ion binding//structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.57548 BF_2 164.53 1.30 5576 642915644 XP_972006.3 2069 4.4e-229 PREDICTED: uncharacterized protein LOC660704 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ULL1 761 8.5e-79 Pleckstrin homology domain-containing family G member 1 OS=Homo sapiens GN=PLEKHG1 PE=1 SV=2 PF00621 RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG3518 Putative guanine nucleotide exchange factor Cluster-8309.57549 BF_2 106.57 0.86 5465 546681139 ERL91289.1 1495 1.6e-162 hypothetical protein D910_08622 [Dendroctonus ponderosae] -- -- -- -- -- K10865 MRE11 double-strand break repair protein MRE11 http://www.genome.jp/dbget-bin/www_bget?ko:K10865 Q9W6K1 1099 5.3e-118 Double-strand break repair protein MRE11 OS=Xenopus laevis GN=mre11 PE=2 SV=1 PF00149//PF00614//PF09003//PF04152 Calcineurin-like phosphoesterase//Phospholipase D Active site motif//Bacteriophage lambda integrase, N-terminal domain//Mre11 DNA-binding presumed domain GO:0006302//GO:0015074 double-strand break repair//DNA integration GO:0003677//GO:0016787//GO:0003824//GO:0004519//GO:0030145//GO:0008907 DNA binding//hydrolase activity//catalytic activity//endonuclease activity//manganese ion binding//integrase activity GO:0005634 nucleus KOG2310 DNA repair exonuclease MRE11 Cluster-8309.57552 BF_2 46.67 0.79 2774 642940152 XP_008194842.1 1239 3.9e-133 PREDICTED: myoneurin-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W0K4 337 6.2e-30 Protein bric-a-brac 2 OS=Drosophila melanogaster GN=bab2 PE=1 SV=2 PF00651//PF02714 BTB/POZ domain//Calcium-dependent channel, 7TM region, putative phosphate -- -- GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.57553 BF_2 4.00 1.53 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57555 BF_2 5.00 7.00 301 -- -- -- -- -- 269812125 GU138663.1 247 6.06841e-125 Pythium ultimum culture-collection CBS:398.51 mitochondrion, complete genome -- -- -- -- -- -- -- -- PF03366 YEATS family GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8309.57557 BF_2 1.00 0.37 398 1030731 CAA32198.1 200 1.7e-13 polyprotein [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- P20825 154 1.5e-09 Retrovirus-related Pol polyprotein from transposon 297 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.57561 BF_2 21.76 1.03 1175 332374952 AEE62617.1 384 2.3e-34 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O88994 248 5.5e-20 Mitochondrial amidoxime reducing component 2 OS=Rattus norvegicus GN=Marc2 PE=2 SV=1 PF03473 MOSC domain -- -- GO:0003824//GO:0030151//GO:0030170 catalytic activity//molybdenum ion binding//pyridoxal phosphate binding -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.57563 BF_2 137.40 5.02 1432 332374952 AEE62617.1 756 2.0e-77 unknown [Dendroctonus ponderosae]>gi|546684064|gb|ERL93787.1| hypothetical protein D910_11073 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O88994 366 1.4e-33 Mitochondrial amidoxime reducing component 2 OS=Rattus norvegicus GN=Marc2 PE=2 SV=1 PF03473 MOSC domain -- -- GO:0030151//GO:0030170//GO:0003824 molybdenum ion binding//pyridoxal phosphate binding//catalytic activity -- -- KOG2362 Uncharacterized Fe-S protein Cluster-8309.57570 BF_2 154.00 11.43 851 270001056 EEZ97503.1 293 5.8e-24 hypothetical protein TcasGA2_TC011347 [Tribolium castaneum] -- -- -- -- -- K18186 PET100 protein PET100, animal type http://www.genome.jp/dbget-bin/www_bget?ko:K18186 P0DJE0 182 1.8e-12 Protein PET100 homolog, mitochondrial OS=Mus musculus GN=Pet100 PE=1 SV=1 PF09803 Uncharacterized conserved protein (DUF2346) GO:0033617 mitochondrial respiratory chain complex IV assembly -- -- GO:0005739 mitochondrion -- -- Cluster-8309.57571 BF_2 93.84 0.81 5130 642928752 XP_008199768.1 3712 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642928754|ref|XP_008199769.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] 642928753 XM_008201547.1 607 0 PREDICTED: Tribolium castaneum nephrin (LOC663184), transcript variant X2, mRNA -- -- -- -- Q9QZS7 218 7.2e-16 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF13895//PF00041 Immunoglobulin domain//Fibronectin type III domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.57573 BF_2 38.95 0.41 4246 642914918 XP_008190441.1 1326 4.8e-143 PREDICTED: WD repeat-containing protein 34-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96EX3 372 8.3e-34 WD repeat-containing protein 34 OS=Homo sapiens GN=WDR34 PE=1 SV=2 PF03306//PF00400//PF14895//PF12515 Alpha-acetolactate decarboxylase//WD domain, G-beta repeat//Protein phosphatase 1 inhibitor//Ca2+-ATPase N terminal autoinhibitory domain GO:0045151//GO:0010923 acetoin biosynthetic process//negative regulation of phosphatase activity GO:0047605//GO:0005515//GO:0005516//GO:0019902 acetolactate decarboxylase activity//protein binding//calmodulin binding//phosphatase binding -- -- KOG3134 Predicted membrane protein Cluster-8309.57582 BF_2 5.20 5.85 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57584 BF_2 6.00 0.70 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57585 BF_2 33.80 0.33 4567 91087437 XP_975683.1 1563 1.7e-170 PREDICTED: calbindin-32 isoform X2 [Tribolium castaneum]>gi|270009492|gb|EFA05940.1| hypothetical protein TcasGA2_TC008758 [Tribolium castaneum] 768416565 XM_011550577.1 347 2.63652e-179 PREDICTED: Plutella xylostella calbindin-32 (LOC105380953), mRNA -- -- -- -- P41044 1359 3.2e-148 Calbindin-32 OS=Drosophila melanogaster GN=Cbp53E PE=2 SV=1 PF00036//PF13833//PF13405//PF13499//PF13202//PF12763 EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.57586 BF_2 5.00 0.42 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57588 BF_2 393.00 21.38 1056 91094675 XP_967123.1 931 7.6e-98 PREDICTED: stromal cell-derived factor 2 [Tribolium castaneum]>gi|270016502|gb|EFA12948.1| hypothetical protein TcasGA2_TC005068 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99470 561 2.5e-56 Stromal cell-derived factor 2 OS=Homo sapiens GN=SDF2 PE=1 SV=2 PF02815 MIR domain -- -- -- -- GO:0016020 membrane KOG3358 Uncharacterized secreted protein SDF2 (Stromal cell-derived factor 2), contains MIR domains Cluster-8309.57595 BF_2 24.07 0.31 3496 642926330 XP_008194880.1 3517 0.0e+00 PREDICTED: RING finger protein 207 isoform X1 [Tribolium castaneum]>gi|270008488|gb|EFA04936.1| hypothetical protein TcasGA2_TC015003 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.81517e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 938 1.6e-99 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF04513//PF04673//PF13639//PF06005//PF14634//PF00643//PF00097 Baculovirus polyhedron envelope protein, PEP, C terminus//Polyketide synthesis cyclase//Ring finger domain//Protein of unknown function (DUF904)//zinc-RING finger domain//B-box zinc finger//Zinc finger, C3HC4 type (RING finger) GO:0030639//GO:0043093//GO:0000917 polyketide biosynthetic process//FtsZ-dependent cytokinesis//barrier septum assembly GO:0005515//GO:0005198//GO:0008270//GO:0046872 protein binding//structural molecule activity//zinc ion binding//metal ion binding GO:0019028//GO:0019031//GO:0005622//GO:0005737 viral capsid//viral envelope//intracellular//cytoplasm -- -- Cluster-8309.57598 BF_2 45.68 2.07 1210 531446199 AGT57842.1 1456 1.2e-158 cytochrome P450 302a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10721 DIB CYP302A1; ecdysteroid 22-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10721 Q9NGX9 904 4.8e-96 Cytochrome P450 302a1, mitochondrial OS=Drosophila melanogaster GN=dib PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.576 BF_2 2.00 1.15 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57602 BF_2 66.17 5.35 805 759082852 XP_011351320.1 451 2.6e-42 PREDICTED: delta-aminolevulinic acid dehydratase [Cerapachys biroi]>gi|759082854|ref|XP_011351321.1| PREDICTED: delta-aminolevulinic acid dehydratase [Cerapachys biroi]>gi|607347768|gb|EZA46379.1| Delta-aminolevulinic acid dehydratase [Cerapachys biroi] -- -- -- -- -- K01698 hemB, ALAD porphobilinogen synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01698 P13716 430 3.0e-41 Delta-aminolevulinic acid dehydratase OS=Homo sapiens GN=ALAD PE=1 SV=1 PF00490 Delta-aminolevulinic acid dehydratase GO:0033014//GO:0015994 tetrapyrrole biosynthetic process//chlorophyll metabolic process GO:0004655//GO:0046872 porphobilinogen synthase activity//metal ion binding -- -- KOG2794 Delta-aminolevulinic acid dehydratase Cluster-8309.57604 BF_2 79.63 0.35 9681 642936015 XP_008198269.1 2544 6.4e-284 PREDICTED: histone-lysine N-methyltransferase NSD2 [Tribolium castaneum]>gi|270014006|gb|EFA10454.1| hypothetical protein TcasGA2_TC012700 [Tribolium castaneum] -- -- -- -- -- K15588 NSD1 histone-lysine N-methyltransferase NSD1 http://www.genome.jp/dbget-bin/www_bget?ko:K15588 O88491 1591 8.4e-175 Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific OS=Mus musculus GN=Nsd1 PE=1 SV=1 PF08198//PF15184//PF00628//PF00439//PF03137//PF00856 Thymopoietin protein//Mitochondrial import receptor subunit TOM6 homolog//PHD-finger//Bromodomain//Organic Anion Transporter Polypeptide (OATP) family//SET domain GO:0032259//GO:0006810 methylation//transport GO:0043169//GO:0008168//GO:0003677//GO:0005515//GO:0005215 cation binding//methyltransferase activity//DNA binding//protein binding//transporter activity GO:0016020//GO:0005742 membrane//mitochondrial outer membrane translocase complex KOG4442 Clathrin coat binding protein/Huntingtin interacting protein HIP1, involved in regulation of endocytosis Cluster-8309.57611 BF_2 45.55 1.42 1633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57612 BF_2 22.23 0.64 1729 478257733 ENN77876.1 1120 1.5e-119 hypothetical protein YQE_05554, partial [Dendroctonus ponderosae]>gi|546687636|gb|ERL96238.1| hypothetical protein D910_01526 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57615 BF_2 49.11 0.46 4726 752866884 XP_011250445.1 2335 5.4e-260 PREDICTED: SCAN domain-containing protein 3-like [Camponotus floridanus] 751233256 XM_011171998.1 377 0 PREDICTED: Solenopsis invicta zinc finger BED domain-containing protein 5-like (LOC105203223), mRNA -- -- -- -- Q6R2W3 816 3.0e-85 SCAN domain-containing protein 3 OS=Homo sapiens GN=ZBED9 PE=2 SV=1 PF05699//PF02892//PF06305 hAT family C-terminal dimerisation region//BED zinc finger//Protein of unknown function (DUF1049) -- -- GO:0046983//GO:0003677 protein dimerization activity//DNA binding GO:0005887 integral component of plasma membrane -- -- Cluster-8309.57619 BF_2 3.00 0.39 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57622 BF_2 1.77 0.34 502 642926894 XP_008195055.1 634 9.9e-64 PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926896|ref|XP_008195056.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|642926898|ref|XP_008195057.1| PREDICTED: ATP-binding cassette sub-family A member 5-like [Tribolium castaneum]>gi|270009201|gb|EFA05649.1| hypothetical protein TcasGA2_TC015859 [Tribolium castaneum] -- -- -- -- -- K05648 ABCA5 ATP-binding cassette, subfamily A (ABC1), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05648 Q8WWZ7 285 1.2e-24 ATP-binding cassette sub-family A member 5 OS=Homo sapiens GN=ABCA5 PE=2 SV=2 -- -- GO:0006200 obsolete ATP catabolic process GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- KOG0059 Lipid exporter ABCA1 and related proteins, ABC superfamily Cluster-8309.57623 BF_2 35.66 0.36 4412 642922778 XP_008193321.1 2493 2.4e-278 PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 4.4e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13176//PF13414//PF13174//PF00515//PF13374//PF13181//PF02827 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.57624 BF_2 55.89 0.55 4535 642922778 XP_008193321.1 2493 2.5e-278 PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 4.5e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13174//PF13414//PF13176//PF02827//PF13374//PF13181//PF00515 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.57627 BF_2 8.56 0.65 840 642919406 XP_008191856.1 365 2.6e-32 PREDICTED: dnaJ homolog subfamily C member 24 [Tribolium castaneum]>gi|642919408|ref|XP_008191857.1| PREDICTED: dnaJ homolog subfamily C member 24 [Tribolium castaneum]>gi|270005821|gb|EFA02269.1| hypothetical protein TcasGA2_TC007933 [Tribolium castaneum] -- -- -- -- -- K17867 DPH4, DNAJC24 diphthamide biosynthesis protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K17867 Q0VBY7 211 7.6e-16 DnaJ homolog subfamily C member 24 OS=Bos taurus GN=DNAJC24 PE=2 SV=2 PF05485 THAP domain -- -- GO:0005515//GO:0003676 protein binding//nucleic acid binding -- -- KOG0713 Molecular chaperone (DnaJ superfamily) Cluster-8309.57632 BF_2 94.51 1.39 3138 642927554 XP_008195313.1 3133 0.0e+00 PREDICTED: UPF0505 protein C16orf62 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z3J2 2101 2.0e-234 UPF0505 protein C16orf62 OS=Homo sapiens GN=C16orf62 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3682 Predicted membrane protein (associated with esophageal cancer in humans) Cluster-8309.57633 BF_2 66.52 1.01 3042 270010177 EFA06625.1 3083 0.0e+00 hypothetical protein TcasGA2_TC009544 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z3J2 2084 1.8e-232 UPF0505 protein C16orf62 OS=Homo sapiens GN=C16orf62 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3682 Predicted membrane protein (associated with esophageal cancer in humans) Cluster-8309.57636 BF_2 97.35 1.45 3088 795013623 XP_011883597.1 900 8.7e-94 PREDICTED: uncharacterized protein LOC105570767 isoform X2 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- Q7M3K2 135 1.8e-06 Transposable element P transposase OS=Drosophila melanogaster GN=T PE=1 SV=2 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.57637 BF_2 21.00 1.68 810 557121890 CDI80615.1 516 7.7e-50 translation initiation factor eIF-5A, putative [Eimeria acervulina] 349711535 FQ379154.1 323 9.9197e-167 Vitis vinifera clone SS0AEB11YE20 K03263 EIF5A translation initiation factor 5A http://www.genome.jp/dbget-bin/www_bget?ko:K03263 P24922 795 1.4e-83 Eukaryotic translation initiation factor 5A-2 OS=Nicotiana plumbaginifolia GN=EIF-5A2 PE=2 SV=1 PF01287 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold GO:0045905//GO:0045901//GO:0006452//GO:0006448 positive regulation of translational termination//positive regulation of translational elongation//translational frameshifting//regulation of translational elongation GO:0003746//GO:0043022//GO:0003723 translation elongation factor activity//ribosome binding//RNA binding GO:0005840 ribosome KOG3271 Translation initiation factor 5A (eIF-5A) Cluster-8309.57650 BF_2 66.56 1.60 2024 478253800 ENN74092.1 1231 2.4e-132 hypothetical protein YQE_09065, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q69ZF8 317 9.4e-28 E3 ubiquitin-protein ligase MSL2 OS=Mus musculus GN=Msl2 PE=2 SV=2 PF00706//PF16685 Anenome neurotoxin//zinc RING finger of MSL2 GO:0009966 regulation of signal transduction GO:0061630 ubiquitin protein ligase activity GO:0005576 extracellular region -- -- Cluster-8309.57652 BF_2 45.00 1.86 1300 844837396 XP_012792468.1 207 8.4e-14 Chromobox protein 8 [Schistosoma haematobium]>gi|685956510|gb|KGB32687.1| Chromobox protein 8 [Schistosoma haematobium] -- -- -- -- -- K11455 CBX8, PC3 chromobox protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K11455 Q9HC52 162 5.7e-10 Chromobox protein homolog 8 OS=Homo sapiens GN=CBX8 PE=1 SV=3 PF06524//PF01552 NOA36 protein//Picornavirus 2B protein GO:0006508//GO:0006144//GO:0018144 proteolysis//purine nucleobase metabolic process//RNA-protein covalent cross-linking GO:0016779//GO:0008233//GO:0008234//GO:0008270//GO:0000166//GO:0003968//GO:0005198//GO:0016740//GO:0016787 nucleotidyltransferase activity//peptidase activity//cysteine-type peptidase activity//zinc ion binding//nucleotide binding//RNA-directed RNA polymerase activity//structural molecule activity//transferase activity//hydrolase activity GO:0031379//GO:0019012//GO:0005634 RNA-directed RNA polymerase complex//virion//nucleus KOG2748 Uncharacterized conserved protein, contains chromo domain Cluster-8309.57660 BF_2 25.09 0.47 2540 158294276 XP_001688670.1 369 2.7e-32 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768430547 XM_011558205.1 125 3.74026e-56 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105387473), transcript variant X3, mRNA >gnl|BL_ORD_ID|28135220 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105389571), transcript variant X3, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47194 284 7.9e-24 Synaptobrevin OS=Doryteuthis pealeii PE=1 SV=1 PF00957//PF04799//PF00517//PF15461 Synaptobrevin//fzo-like conserved region//Retroviral envelope protein//Beta-carotene 15,15'-dioxygenase GO:0055114//GO:0008053//GO:0016192 oxidation-reduction process//mitochondrial fusion//vesicle-mediated transport GO:0003924//GO:0016702//GO:0005198 GTPase activity//oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//structural molecule activity GO:0005741//GO:0019031//GO:0016021 mitochondrial outer membrane//viral envelope//integral component of membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.57661 BF_2 4.00 2.19 360 158294276 XP_001688670.1 230 5.0e-17 AGAP005507-PB [Anopheles gambiae str. PEST]>gi|158294278|ref|XP_001688671.1| AGAP005507-PA [Anopheles gambiae str. PEST]>gi|157015489|gb|EDO63676.1| AGAP005507-PB [Anopheles gambiae str. PEST]>gi|157015490|gb|EDO63677.1| AGAP005507-PA [Anopheles gambiae str. PEST] 768437333 XM_011561901.1 69 6.5939e-26 PREDICTED: Plutella xylostella vesicle-associated membrane protein 2-like (LOC105390573), transcript variant X2, mRNA K13504 VAMP2 vesicle-associated membrane protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K13504 P47193 180 1.3e-12 Vesicle-associated membrane protein 2 OS=Xenopus laevis GN=vamp2 PE=3 SV=3 PF00957 Synaptobrevin GO:0016192 vesicle-mediated transport -- -- GO:0016021 integral component of membrane KOG0860 Synaptobrevin/VAMP-like protein Cluster-8309.57668 BF_2 3.40 0.67 499 270013658 EFA10106.1 252 1.9e-19 hypothetical protein TcasGA2_TC012285 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.57672 BF_2 8.21 0.78 730 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57683 BF_2 23.23 0.70 1672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08437 Glycosyl transferase family 8 C-terminal GO:0009103 lipopolysaccharide biosynthetic process GO:0008918 lipopolysaccharide 3-alpha-galactosyltransferase activity -- -- -- -- Cluster-8309.57687 BF_2 75.38 1.22 2878 91090768 XP_969213.1 982 2.5e-103 PREDICTED: protein artemis [Tribolium castaneum]>gi|270013270|gb|EFA09718.1| hypothetical protein TcasGA2_TC011851 [Tribolium castaneum] -- -- -- -- -- K10887 DCLRE1C, ARTEMIS, SCIDA DNA cross-link repair 1C protein http://www.genome.jp/dbget-bin/www_bget?ko:K10887 Q5QJC2 500 8.1e-49 Protein artemis OS=Gallus gallus GN=DCLRE1C PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1361 Predicted hydrolase involved in interstrand cross-link repair Cluster-8309.57691 BF_2 80.65 2.01 1966 642918258 XP_008191434.1 1452 5.5e-158 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918260|ref|XP_008191435.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918262|ref|XP_008191436.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q1HG43 346 4.0e-31 Dual oxidase maturation factor 1 OS=Homo sapiens GN=DUOXA1 PE=1 SV=1 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane KOG3921 Uncharacterized conserved protein Cluster-8309.57696 BF_2 30.75 0.70 2113 91076754 XP_973519.1 1078 1.4e-114 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZS6 331 2.3e-29 Synaptic vesicle glycoprotein 2C OS=Mus musculus GN=Sv2c PE=1 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57697 BF_2 15.73 0.46 1716 91076754 XP_973519.1 1026 1.2e-108 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG39 193 1.9e-13 Synaptic vesicle glycoprotein 2B OS=Mus musculus GN=Sv2b PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-8309.57699 BF_2 82.02 2.16 1879 91076754 XP_973519.1 1360 2.4e-147 PREDICTED: synaptic vesicle glycoprotein 2C [Tribolium castaneum]>gi|270001914|gb|EEZ98361.1| hypothetical protein TcasGA2_TC000818 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q69ZS6 331 2.1e-29 Synaptic vesicle glycoprotein 2C OS=Mus musculus GN=Sv2c PE=1 SV=2 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.5770 BF_2 4.00 0.42 688 270010138 EFA06586.1 206 5.8e-14 hypothetical protein TcasGA2_TC009500 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.57700 BF_2 4.00 0.76 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57709 BF_2 5.00 0.44 766 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02367 Threonylcarbamoyl adenosine biosynthesis protein TsaE GO:0002949 tRNA threonylcarbamoyladenosine modification -- -- -- -- -- -- Cluster-8309.57710 BF_2 97.00 4.37 1216 642919190 XP_008191775.1 910 2.4e-95 PREDICTED: RNA-binding protein 42 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66KL9 457 3.3e-44 RNA-binding protein 42 OS=Xenopus tropicalis GN=rbm42 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0003676 nucleic acid binding -- -- KOG0226 RNA-binding proteins Cluster-8309.57713 BF_2 184.31 1.80 4573 642912407 XP_008199495.1 3247 0.0e+00 PREDICTED: liprin-alpha-1 isoform X13 [Tribolium castaneum] 642912406 XM_008201273.1 742 0 PREDICTED: Tribolium castaneum liprin-alpha-1 (LOC658901), transcript variant X13, mRNA -- -- -- -- O75334 1539 4.3e-169 Liprin-alpha-2 OS=Homo sapiens GN=PPFIA2 PE=1 SV=2 PF05513//PF02459 TraA//Adenoviral DNA terminal protein GO:0000746//GO:0006260 conjugation//DNA replication GO:0003677 DNA binding GO:0005576 extracellular region KOG0249 LAR-interacting protein and related proteins Cluster-8309.57720 BF_2 14.34 0.35 2004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096 Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.57721 BF_2 5.02 1.00 497 332376240 AEE63260.1 298 9.0e-25 unknown [Dendroctonus ponderosae]>gi|478251203|gb|ENN71677.1| hypothetical protein YQE_11601, partial [Dendroctonus ponderosae]>gi|546676175|gb|ERL87242.1| hypothetical protein D910_04640 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O81884 140 7.7e-08 L-galactose dehydrogenase OS=Arabidopsis thaliana GN=LGALDH PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1576 Predicted oxidoreductase Cluster-8309.57727 BF_2 5.00 5.23 316 149287056 ABR23427.1 408 1.0e-37 ribosomal protein L37A [Ornithodoros parkeri] -- -- -- -- -- K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 Q9VMU4 371 8.0e-35 60S ribosomal protein L37a OS=Drosophila melanogaster GN=RpL37A PE=1 SV=3 PF01780//PF02892 Ribosomal L37ae protein family//BED zinc finger GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0003677 structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG0402 60S ribosomal protein L37 Cluster-8309.57729 BF_2 40.76 2.00 1141 642914619 XP_008190286.1 1110 1.4e-118 PREDICTED: Kv channel-interacting protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYN7 606 1.6e-61 Kv channel-interacting protein 4 OS=Macaca fascicularis GN=KCNIP4 PE=2 SV=1 PF13499//PF13405//PF10591//PF13833//PF12763//PF04434//PF00036//PF13202 EF-hand domain pair//EF-hand domain//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//SWIM zinc finger//EF hand//EF hand GO:0007165 signal transduction GO:0008270//GO:0005509//GO:0005515 zinc ion binding//calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.57736 BF_2 1.00 0.43 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5774 BF_2 7.00 0.38 1063 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57740 BF_2 4.73 0.46 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57741 BF_2 34.08 0.57 2788 642917584 XP_008191268.1 1727 1.0e-189 PREDICTED: peroxisome assembly factor 2 [Tribolium castaneum] 640815149 XM_008066140.1 77 1.97997e-29 PREDICTED: Tarsius syrichta peroxisomal biogenesis factor 6 (PEX6), transcript variant X2, mRNA K13339 PEX6, PXAAA1 peroxin-6 http://www.genome.jp/dbget-bin/www_bget?ko:K13339 Q13608 979 2.2e-104 Peroxisome assembly factor 2 OS=Homo sapiens GN=PEX6 PE=1 SV=2 PF02367//PF02562//PF07726//PF00910//PF00158//PF06068//PF01057//PF05496//PF07728//PF14532//PF01695//PF07724//PF00004 Threonylcarbamoyl adenosine biosynthesis protein TsaE//PhoH-like protein//ATPase family associated with various cellular activities (AAA)//RNA helicase//Sigma-54 interaction domain//TIP49 C-terminus//Parvovirus non-structural protein NS1//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//Sigma-54 interaction domain//IstB-like ATP binding protein//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0006355//GO:0002949//GO:0019079//GO:0006281 DNA recombination//regulation of transcription, DNA-templated//tRNA threonylcarbamoyladenosine modification//viral genome replication//DNA repair GO:0016887//GO:0003724//GO:0009378//GO:0003723//GO:0005524//GO:0003678//GO:0008134 ATPase activity//RNA helicase activity//four-way junction helicase activity//RNA binding//ATP binding//DNA helicase activity//transcription factor binding GO:0005657//GO:0009379//GO:0005667 replication fork//Holliday junction helicase complex//transcription factor complex KOG0736 Peroxisome assembly factor 2 containing the AAA+-type ATPase domain Cluster-8309.57745 BF_2 14.00 1.17 786 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5775 BF_2 77.13 1.06 3326 91094585 XP_969953.1 1523 5.4e-166 PREDICTED: parathyroid hormone/parathyroid hormone-related peptide receptor [Tribolium castaneum]>gi|270016404|gb|EFA12850.1| hypothetical protein TcasGA2_TC010267 [Tribolium castaneum]>gi|570932721|gb|AHF20217.1| parathyroid hormone receptor like 2 [Tribolium castaneum] -- -- -- -- -- K04585 PTHR1 parathyroid hormone receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04585 P25107 598 4.0e-60 Parathyroid hormone/parathyroid hormone-related peptide receptor OS=Didelphis virginiana GN=PTH1R PE=2 SV=2 PF00800//PF00466//PF02793//PF00002 Prephenate dehydratase//Ribosomal protein L10//Hormone receptor domain//7 transmembrane receptor (Secretin family) GO:0042254//GO:0000162//GO:0006571//GO:0007186//GO:0009094//GO:0007165 ribosome biogenesis//tryptophan biosynthetic process//tyrosine biosynthetic process//G-protein coupled receptor signaling pathway//L-phenylalanine biosynthetic process//signal transduction GO:0004871//GO:0004664//GO:0004930 signal transducer activity//prephenate dehydratase activity//G-protein coupled receptor activity GO:0016020//GO:0005622//GO:0016021 membrane//intracellular//integral component of membrane -- -- Cluster-8309.57751 BF_2 6.15 0.48 826 478253905 ENN74197.1 363 4.3e-32 hypothetical protein YQE_09170, partial [Dendroctonus ponderosae] -- -- -- -- -- K11649 SMARCC SWI/SNF related-matrix-associated actin-dependent regulator of chromatin subfamily C http://www.genome.jp/dbget-bin/www_bget?ko:K11649 Q8TAQ2 252 1.3e-20 SWI/SNF complex subunit SMARCC2 OS=Homo sapiens GN=SMARCC2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57757 BF_2 41.52 1.09 1877 642917480 XP_008191219.1 606 6.6e-60 PREDICTED: probable RNA-binding protein 18 [Tribolium castaneum]>gi|270004407|gb|EFA00855.1| hypothetical protein TcasGA2_TC003758 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PBM8 188 8.0e-13 Probable RNA-binding protein 18 OS=Danio rerio GN=rbm18 PE=2 SV=1 -- -- -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- -- -- Cluster-8309.5776 BF_2 12.13 0.89 860 668456044 KFB44253.1 285 5.0e-23 AGAP009875-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- Q7M4F3 232 2.9e-18 Endocuticle structural glycoprotein SgAbd-2 OS=Schistocerca gregaria PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57769 BF_2 4.00 1.45 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57771 BF_2 24.06 0.35 3128 861625668 KMQ88610.1 201 1.0e-12 kda protein in nof-fb transposable element [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal GO:0008610 lipid biosynthetic process GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.57773 BF_2 12.78 0.39 1644 189239358 XP_974445.2 1222 2.1e-131 PREDICTED: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [Tribolium castaneum] 817088660 XM_012411735.1 54 7.06858e-17 PREDICTED: Athalia rosae tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (LOC105692505), transcript variant X2, mRNA K05545 DUS4 tRNA-dihydrouridine synthase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05545 Q32M08 710 2.1e-73 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus4l PE=2 SV=1 PF01207//PF00977 Dihydrouridine synthase (Dus)//Histidine biosynthesis protein GO:0000105//GO:0055114//GO:0008033 histidine biosynthetic process//oxidation-reduction process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.57774 BF_2 201.00 2.02 4459 861463488 XP_004855271.2 428 6.8e-39 PREDICTED: zinc finger protein 397 [Heterocephalus glaber] 641738213 XM_008161585.1 110 1.43922e-47 PREDICTED: Eptesicus fuscus zinc finger protein Gfi-1b (LOC103304778), transcript variant X2, mRNA >gnl|BL_ORD_ID|19479967 PREDICTED: Eptesicus fuscus zinc finger protein Gfi-1b (LOC103304819), transcript variant X2, mRNA K09223 GFI1 growth factor independent 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09223 Q05481 423 1.1e-39 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF13465//PF00096//PF00130//PF01155//PF02892//PF13912//PF01428 Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//BED zinc finger//C2H2-type zinc finger//AN1-like Zinc finger GO:0035556//GO:0006464 intracellular signal transduction//cellular protein modification process GO:0016151//GO:0046872//GO:0008270//GO:0003677 nickel cation binding//metal ion binding//zinc ion binding//DNA binding -- -- -- -- Cluster-8309.5778 BF_2 13.74 1.07 822 642921037 XP_008192665.1 628 8.1e-63 PREDICTED: uncharacterized protein LOC103312818 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NZL6 142 7.5e-08 Ral guanine nucleotide dissociation stimulator-like 1 OS=Homo sapiens GN=RGL1 PE=1 SV=1 PF00617 RasGEF domain GO:0007264//GO:0043087 small GTPase mediated signal transduction//regulation of GTPase activity GO:0005085 guanyl-nucleotide exchange factor activity -- -- KOG3417 Ras1 guanine nucleotide exchange factor Cluster-8309.57784 BF_2 237.68 5.02 2269 546677640 ERL88441.1 1731 2.8e-190 hypothetical protein D910_05827 [Dendroctonus ponderosae] -- -- -- -- -- K11214 SHPK sedoheptulokinase http://www.genome.jp/dbget-bin/www_bget?ko:K11214 Q9D5J6 1023 1.4e-109 Sedoheptulokinase OS=Mus musculus GN=Shpk PE=1 SV=1 PF00370//PF01926 FGGY family of carbohydrate kinases, N-terminal domain//50S ribosome-binding GTPase GO:0005975 carbohydrate metabolic process GO:0016773//GO:0005525 phosphotransferase activity, alcohol group as acceptor//GTP binding -- -- -- -- Cluster-8309.57787 BF_2 31.72 0.39 3722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0008277//GO:0015031//GO:0006886 regulation of G-protein coupled receptor protein signaling pathway//protein transport//intracellular protein transport GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57793 BF_2 69.73 1.17 2782 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.57799 BF_2 43.66 0.63 3169 619498812 AHY03304.1 537 1.1e-51 caspase-1 [Dastarcus helophoroides] -- -- -- -- -- K04489 CASPN caspase invertebrate, apoptosis-related cysteine protease http://www.genome.jp/dbget-bin/www_bget?ko:K04489 P89116 512 3.6e-50 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.578 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57803 BF_2 2.00 0.52 449 642928111 XP_008200161.1 170 5.6e-10 PREDICTED: E3 ubiquitin-protein ligase TRAIP isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13639//PF00097//PF17123//PF12678//PF00628//PF12861//PF14634 Ring finger domain//Zinc finger, C3HC4 type (RING finger)//RING-like zinc finger//RING-H2 zinc finger//PHD-finger//Anaphase-promoting complex subunit 11 RING-H2 finger//zinc-RING finger domain GO:0016567 protein ubiquitination GO:0008270//GO:0004842//GO:0005515//GO:0046872 zinc ion binding//ubiquitin-protein transferase activity//protein binding//metal ion binding GO:0005680 anaphase-promoting complex -- -- Cluster-8309.57806 BF_2 138.26 3.36 2011 642911217 XP_008199631.1 1556 4.9e-170 PREDICTED: FCH domain only protein 2 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q502I9 648 3.9e-66 F-BAR domain only protein 2 OS=Danio rerio GN=fcho2 PE=2 SV=1 PF02662 Methyl-viologen-reducing hydrogenase, delta subunit GO:0055114//GO:0015948 oxidation-reduction process//methanogenesis -- -- -- -- KOG2398 Predicted proline-serine-threonine phosphatase-interacting protein (PSTPIP) Cluster-8309.5781 BF_2 6.00 1.51 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57811 BF_2 15.41 1.20 826 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57813 BF_2 18.75 0.77 1311 270005418 EFA01866.1 141 3.8e-06 hypothetical protein TcasGA2_TC007471 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57815 BF_2 4.00 0.41 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57825 BF_2 7.00 0.82 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57828 BF_2 24.28 0.60 1988 755545949 XP_011242903.1 916 7.8e-96 PREDICTED: zinc finger protein 431-like, partial [Mus musculus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 875 1.8e-92 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF00940//PF00096//PF05864//PF07776//PF13465//PF04810//PF01020//PF13912//PF16622 DNA-dependent RNA polymerase//Zinc finger, C2H2 type//Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Sec23/Sec24 zinc finger//Ribosomal L40e family//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006351//GO:0006412//GO:0006888//GO:0006144//GO:0006206//GO:0006886//GO:0042254 transcription, DNA-templated//translation//ER to Golgi vesicle-mediated transport//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//intracellular protein transport//ribosome biogenesis GO:0003677//GO:0046872//GO:0003899//GO:0008270//GO:0003735 DNA binding//metal ion binding//DNA-directed RNA polymerase activity//zinc ion binding//structural constituent of ribosome GO:0005634//GO:0030127//GO:0005840//GO:0005730 nucleus//COPII vesicle coat//ribosome//nucleolus -- -- Cluster-8309.5783 BF_2 9.00 1.76 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57832 BF_2 116.41 1.88 2871 478251160 ENN71636.1 2129 2.5e-236 hypothetical protein YQE_11734, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17001//PF01665//PF04843 Type III secretion basal body protein I, YscI, HrpB, PscI//Rotavirus non-structural protein NSP3//Herpesvirus tegument protein, N-terminal conserved region GO:0009306//GO:0006508 protein secretion//proteolysis GO:0008233//GO:0003723 peptidase activity//RNA binding -- -- -- -- Cluster-8309.57841 BF_2 3.00 0.37 624 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57842 BF_2 4.06 0.43 679 607360166 EZA54504.1 138 4.4e-06 hypothetical protein X777_05483 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57845 BF_2 98.69 1.45 3142 642918773 XP_008191578.1 3748 0.0e+00 PREDICTED: calpain-D-like isoform X2 [Tribolium castaneum] 194768179 XM_001966155.1 202 7.27939e-99 Drosophila ananassae GF19541 (Dana\GF19541), mRNA K08582 CAPN15 calpain-15 http://www.genome.jp/dbget-bin/www_bget?ko:K08582 P27398 2414 1.0e-270 Calpain-D OS=Drosophila melanogaster GN=sol PE=1 SV=2 PF00648//PF00641 Calpain family cysteine protease//Zn-finger in Ran binding protein and others GO:0006508 proteolysis GO:0004198//GO:0008270 calcium-dependent cysteine-type endopeptidase activity//zinc ion binding GO:0005622 intracellular KOG0045 Cytosolic Ca2+-dependent cysteine protease (calpain), large subunit (EF-Hand protein superfamily) Cluster-8309.57847 BF_2 16.00 18.72 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57848 BF_2 14.00 5.01 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57850 BF_2 1.00 0.60 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04145 Ctr copper transporter family GO:0035434//GO:0006825 copper ion transmembrane transport//copper ion transport GO:0005375 copper ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.57857 BF_2 10.53 0.36 1500 189242442 XP_001807060.1 138 9.7e-06 PREDICTED: cytokine receptor [Tribolium castaneum]>gi|270016376|gb|EFA12822.1| domeless [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57860 BF_2 145.15 5.34 1425 642924737 XP_008194418.1 987 3.3e-104 PREDICTED: protein-S-isoprenylcysteine O-methyltransferase [Tribolium castaneum]>gi|270006711|gb|EFA03159.1| hypothetical protein TcasGA2_TC013078 [Tribolium castaneum] 242016078 XM_002428618.1 45 6.14984e-12 Pediculus humanus corporis protein-S-isoprenylcysteine O-methyltransferase, putative, mRNA K00587 ICMT, STE14 protein-S-isoprenylcysteine O-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00587 O12947 722 7.2e-75 Protein-S-isoprenylcysteine O-methyltransferase OS=Xenopus laevis GN=icmt PE=2 SV=1 PF00951//PF04140 Arterivirus GL envelope glycoprotein//Isoprenylcysteine carboxyl methyltransferase (ICMT) family GO:0006481//GO:0006479 C-terminal protein methylation//protein methylation GO:0004671 protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity GO:0005783//GO:0019031//GO:0016021 endoplasmic reticulum//viral envelope//integral component of membrane KOG2628 Farnesyl cysteine-carboxyl methyltransferase Cluster-8309.57863 BF_2 1.00 1.17 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57864 BF_2 141.15 3.50 1975 91090228 XP_968551.1 523 2.9e-50 PREDICTED: uncharacterized protein LOC656965 [Tribolium castaneum]>gi|270013773|gb|EFA10221.1| hypothetical protein TcasGA2_TC012417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15761//PF12052//PF00642 Immortalisation up-regulated protein//Voltage gated calcium channel subunit beta domain 4Aa N terminal//Zinc finger C-x8-C-x5-C-x3-H type (and similar) GO:0006816//GO:0070588 calcium ion transport//calcium ion transmembrane transport GO:0005488//GO:0005245//GO:0046872 binding//voltage-gated calcium channel activity//metal ion binding GO:0005634//GO:0005891 nucleus//voltage-gated calcium channel complex -- -- Cluster-8309.57866 BF_2 1.00 0.65 347 270015450 EFA11898.1 148 1.5e-07 hypothetical protein TcasGA2_TC001429 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57869 BF_2 41.66 2.72 928 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57870 BF_2 14.00 1.10 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57881 BF_2 57.00 10.32 518 150416593 ABF60889.2 209 2.0e-14 putative glycine-rich protein [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08140 Crustacean cuticle protein repeat -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.57885 BF_2 2.07 0.35 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57888 BF_2 99.09 1.37 3304 642929595 XP_008195898.1 1187 4.9e-127 PREDICTED: peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform X2 [Tribolium castaneum] -- -- -- -- -- K01456 E3.5.1.52, NGLY1, PNG1 peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01456 Q5ZJM3 804 5.2e-84 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase OS=Gallus gallus GN=NGLY1 PE=2 SV=1 PF08395//PF04721 7tm Chemosensory receptor//PNGase C-terminal domain, mannose-binding module PAW GO:0006516//GO:0050909 glycoprotein catabolic process//sensory perception of taste -- -- GO:0016021//GO:0005737 integral component of membrane//cytoplasm KOG0909 Peptide:N-glycanase Cluster-8309.57890 BF_2 3.00 0.61 494 -- -- -- -- -- 768311755 CP010983.1 389 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57895 BF_2 209.54 3.03 3181 576249472 AHH29250.1 3243 0.0e+00 Bedraggled-like protein [Leptinotarsa decemlineata] 576249471 KC713792.1 605 0 Leptinotarsa decemlineata Bedraggled-like protein mRNA, complete cds K05336 SLC6AN solute carrier family 6 (neurotransmitter transporter), invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05336 Q99884 256 1.8e-20 Sodium-dependent proline transporter OS=Homo sapiens GN=SLC6A7 PE=2 SV=2 PF11421//PF00209 ATP synthase F1 beta subunit//Sodium:neurotransmitter symporter family GO:0006836//GO:0006754//GO:0006812 neurotransmitter transport//ATP biosynthetic process//cation transport GO:0005328//GO:0005524//GO:0016887 neurotransmitter:sodium symporter activity//ATP binding//ATPase activity GO:0000275//GO:0016021 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)//integral component of membrane -- -- Cluster-8309.57896 BF_2 29.00 0.94 1583 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57898 BF_2 6.50 0.34 1093 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57903 BF_2 4.67 0.32 906 91082901 XP_972219.1 315 1.8e-26 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- K13128 ZCCHC8 zinc finger CCHC domain-containing protein 8 http://www.genome.jp/dbget-bin/www_bget?ko:K13128 Q2PE14 266 3.5e-22 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- GO:0005488 binding -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.57910 BF_2 21.62 0.52 2037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57912 BF_2 8.00 1.01 617 642914489 XP_008201696.1 191 2.8e-12 PREDICTED: uncharacterized protein C6orf106 homolog isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57915 BF_2 3.00 0.45 568 769832343 XP_011641658.1 409 1.4e-37 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC105430037 [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01363//PF13639 FYVE zinc finger//Ring finger domain -- -- GO:0008270//GO:0005515//GO:0046872 zinc ion binding//protein binding//metal ion binding -- -- -- -- Cluster-8309.57917 BF_2 18.00 0.34 2491 189237885 XP_975345.2 1591 5.3e-174 PREDICTED: conserved oligomeric Golgi complex subunit 4 [Tribolium castaneum]>gi|270006703|gb|EFA03151.1| hypothetical protein TcasGA2_TC013064 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95TN4 1070 5.6e-115 Conserved oligomeric Golgi complex subunit 4 OS=Drosophila melanogaster GN=CG7456 PE=1 SV=1 PF04111//PF16740//PF00738//PF09177//PF00015//PF04799//PF07393//PF03233//PF06046 Autophagy protein Apg6//Spindle and kinetochore-associated protein 2//Polyhedrin//Syntaxin 6, N-terminal//Methyl-accepting chemotaxis protein (MCP) signalling domain//fzo-like conserved region//Exocyst complex component Sec10//Aphid transmission protein//Exocyst complex component Sec6 GO:0007165//GO:0006914//GO:0000090//GO:0007067//GO:0048278//GO:0051301//GO:0031110//GO:0007059//GO:0019089//GO:0048193//GO:0008053//GO:0006887 signal transduction//autophagy//mitotic anaphase//mitotic nuclear division//vesicle docking//cell division//regulation of microtubule polymerization or depolymerization//chromosome segregation//transmission of virus//Golgi vesicle transport//mitochondrial fusion//exocytosis GO:0005198//GO:0003924//GO:0008017//GO:0004871 structural molecule activity//GTPase activity//microtubule binding//signal transducer activity GO:0016021//GO:0045298//GO:0005737//GO:0005876//GO:0005741//GO:0000145//GO:0000940//GO:0016020 integral component of membrane//tubulin complex//cytoplasm//spindle microtubule//mitochondrial outer membrane//exocyst//condensed chromosome outer kinetochore//membrane KOG0412 Golgi transport complex COD1 protein Cluster-8309.57922 BF_2 36.47 0.79 2226 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57924 BF_2 3.00 0.48 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08997 Ubiquinol-cytochrome C reductase complex, 6.4kD protein GO:0006118//GO:0015992//GO:0006119 obsolete electron transport//proton transport//oxidative phosphorylation GO:0009055//GO:0008121 electron carrier activity//ubiquinol-cytochrome-c reductase activity -- -- -- -- Cluster-8309.57925 BF_2 1.00 10.11 233 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57927 BF_2 5.61 0.37 929 270014079 EFA10527.1 506 1.3e-48 hypothetical protein TcasGA2_TC012779 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2KI00 145 3.8e-08 Protein FAM107B OS=Bos taurus GN=FAM107B PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57930 BF_2 215.00 3.93 2577 189237985 XP_001812669.1 617 4.8e-61 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 2-like [Tribolium castaneum] 665814259 XM_008557510.1 37 3.1492e-07 PREDICTED: Microplitis demolitor biogenesis of lysosome-related organelles complex 1 subunit 2 (LOC103577036), transcript variant X2, mRNA K16750 BLOC1S2 biogenesis of lysosome-related organelles complex 1 subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K16750 Q9VTE0 378 1.0e-34 Biogenesis of lysosome-related organelles complex 1 subunit 2 OS=Drosophila melanogaster GN=blos2 PE=1 SV=2 PF06009//PF08653//PF08702 Laminin Domain II//DASH complex subunit Dam1//Fibrinogen alpha/beta chain family GO:0007165//GO:0051258//GO:0008608//GO:0007155//GO:0030168 signal transduction//protein polymerization//attachment of spindle microtubules to kinetochore//cell adhesion//platelet activation GO:0030674//GO:0005102 protein binding, bridging//receptor binding GO:0072686//GO:0042729//GO:0005577 mitotic spindle//DASH complex//fibrinogen complex KOG4559 Uncharacterized conserved protein Cluster-8309.57937 BF_2 1.00 0.59 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57942 BF_2 21.78 0.68 1622 642927136 XP_972282.2 246 3.1e-18 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NWM0 131 2.8e-06 Spermine oxidase OS=Homo sapiens GN=SMOX PE=1 SV=1 PF01494//PF07992//PF12831//PF01593//PF06100//PF05834//PF01266//PF01134 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Flavin containing amine oxidoreductase//MCRA family//Lycopene cyclase protein//FAD dependent oxidoreductase//Glucose inhibited division protein A GO:0006631//GO:0016117//GO:0055114//GO:0008033 fatty acid metabolic process//carotenoid biosynthetic process//oxidation-reduction process//tRNA processing GO:0050660//GO:0016705//GO:0071949//GO:0050151//GO:0016491 flavin adenine dinucleotide binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//FAD binding//oleate hydratase activity//oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.57944 BF_2 3.00 0.41 590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57948 BF_2 61.97 0.51 5363 270002310 EEZ98757.1 2852 0.0e+00 hypothetical protein TcasGA2_TC001321 [Tribolium castaneum] -- -- -- -- -- K10356 MYO1 myosin I http://www.genome.jp/dbget-bin/www_bget?ko:K10356 O43795 1264 3.9e-137 Unconventional myosin-Ib OS=Homo sapiens GN=MYO1B PE=1 SV=3 PF00063//PF06414//PF09293//PF00612//PF06017//PF00437 Myosin head (motor domain)//Zeta toxin//T4 RNase H, C terminal//IQ calmodulin-binding motif//Unconventional myosin tail, actin- and lipid-binding//Type II/IV secretion system protein GO:0006810 transport GO:0016301//GO:0003774//GO:0003824//GO:0005524//GO:0003677//GO:0005515 kinase activity//motor activity//catalytic activity//ATP binding//DNA binding//protein binding GO:0016459 myosin complex KOG0164 Myosin class I heavy chain Cluster-8309.57956 BF_2 6.00 0.32 1075 391343253 XP_003745927.1 190 6.5e-12 PREDICTED: uncharacterized protein LOC100908740 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57958 BF_2 59.25 0.58 4581 478257224 ENN77387.1 1354 2.9e-146 hypothetical protein YQE_06212, partial [Dendroctonus ponderosae] -- -- -- -- -- K16608 TTLL3_8 tubulin monoglycylase TTLL3/8 http://www.genome.jp/dbget-bin/www_bget?ko:K16608 Q9VM91 753 5.9e-78 Tubulin glycylase 3A OS=Drosophila melanogaster GN=TTLL3A PE=1 SV=1 PF00299//PF07525//PF03133 Squash family serine protease inhibitor//SOCS box//Tubulin-tyrosine ligase family GO:0006464//GO:0035556 cellular protein modification process//intracellular signal transduction GO:0004867 serine-type endopeptidase inhibitor activity -- -- KOG2156 Tubulin-tyrosine ligase-related protein Cluster-8309.57959 BF_2 3.00 0.67 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5796 BF_2 3.89 0.33 787 270008853 EFA05301.1 333 1.2e-28 hypothetical protein TcasGA2_TC015458 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02969 TATA box binding protein associated factor (TAF) GO:0006352 DNA-templated transcription, initiation -- -- GO:0005634 nucleus KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.57968 BF_2 34.77 1.65 1170 640788486 XP_008050052.1 230 1.6e-16 PREDICTED: zinc finger protein 208-like, partial [Tarsius syrichta] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q02525 210 1.4e-15 Zinc finger protein 39 OS=Mus musculus GN=Zfp39 PE=2 SV=2 PF13465//PF00096//PF01363//PF13912//PF06221//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//FYVE zinc finger//C2H2-type zinc finger//Putative zinc finger motif, C2HC5-type//Zinc-finger associated domain (zf-AD) GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.57969 BF_2 46.51 0.39 5273 642927466 XP_008195284.1 1228 1.4e-131 PREDICTED: protein arginine N-methyltransferase 6 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q14914 756 3.1e-78 Prostaglandin reductase 1 OS=Homo sapiens GN=PTGR1 PE=1 SV=2 PF01135//PF05175//PF01370//PF08241//PF02527//PF00208//PF03602//PF01118//PF09243//PF00107//PF05185//PF05401 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//NAD dependent epimerase/dehydratase family//Methyltransferase domain//rRNA small subunit methyltransferase G//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase//Conserved hypothetical protein 95//Semialdehyde dehydrogenase, NAD binding domain//Mitochondrial small ribosomal subunit Rsm22//Zinc-binding dehydrogenase//PRMT5 arginine-N-methyltransferase//Nodulation protein S (NodS) GO:0006412//GO:0008152//GO:0006520//GO:0046500//GO:0009877//GO:0006479//GO:0031167//GO:0006464//GO:0009312//GO:0055114//GO:0000154//GO:0006396//GO:0006364 translation//metabolic process//cellular amino acid metabolic process//S-adenosylmethionine metabolic process//nodulation//protein methylation//rRNA methylation//cellular protein modification process//oligosaccharide biosynthetic process//oxidation-reduction process//rRNA modification//RNA processing//rRNA processing GO:0051287//GO:0016491//GO:0008649//GO:0003824//GO:0008757//GO:0004719//GO:0050662//GO:0016620//GO:0008168 NAD binding//oxidoreductase activity//rRNA methyltransferase activity//catalytic activity//S-adenosylmethionine-dependent methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//coenzyme binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//methyltransferase activity GO:0005737 cytoplasm KOG1499 Protein arginine N-methyltransferase PRMT1 and related enzymes Cluster-8309.57974 BF_2 26.71 1.20 1220 478249806 ENN70313.1 842 1.8e-87 hypothetical protein YQE_12824, partial [Dendroctonus ponderosae]>gi|546682873|gb|ERL92759.1| hypothetical protein D910_10068 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03121//PF06667//PF13895 Herpesviridae UL52/UL70 DNA primase//Phage shock protein B//Immunoglobulin domain GO:0006355//GO:0006269//GO:0006260//GO:0006351//GO:0009271 regulation of transcription, DNA-templated//DNA replication, synthesis of RNA primer//DNA replication//transcription, DNA-templated//phage shock GO:0003896//GO:0005515 DNA primase activity//protein binding GO:0005730//GO:0005657 nucleolus//replication fork -- -- Cluster-8309.57977 BF_2 28.10 0.66 2064 642922521 XP_008193210.1 989 2.8e-104 PREDICTED: kinesin-associated protein 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92845 356 2.9e-32 Kinesin-associated protein 3 OS=Homo sapiens GN=KIFAP3 PE=1 SV=2 PF00514 Armadillo/beta-catenin-like repeat -- -- GO:0005515 protein binding -- -- KOG1222 Kinesin associated protein KAP Cluster-8309.57979 BF_2 2.00 0.75 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.57982 BF_2 77.79 3.51 1215 642927491 XP_008195289.1 589 4.0e-58 PREDICTED: uncharacterized protein LOC103313551 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02076//PF00041 Pheromone A receptor//Fibronectin type III domain GO:0007606//GO:0019236//GO:0007186 sensory perception of chemical stimulus//response to pheromone//G-protein coupled receptor signaling pathway GO:0004932//GO:0005515 mating-type factor pheromone receptor activity//protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.57983 BF_2 3.00 0.58 505 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11744//PF08287//PF09726//PF01080 Aluminium activated malate transporter//Spc19//Transmembrane protein//Presenilin GO:0015743//GO:0008608 malate transport//attachment of spindle microtubules to kinetochore GO:0004190 aspartic-type endopeptidase activity GO:0005876//GO:0016021//GO:0042729 spindle microtubule//integral component of membrane//DASH complex -- -- Cluster-8309.57984 BF_2 11.50 0.84 861 546678787 ERL89339.1 218 2.9e-15 hypothetical protein D910_06710 [Dendroctonus ponderosae] -- -- -- -- -- K15003 CYP9 cytochrome P450, family 9 http://www.genome.jp/dbget-bin/www_bget?ko:K15003 Q964T2 154 3.2e-09 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.57988 BF_2 71.89 1.48 2313 91091470 XP_973218.1 867 4.4e-90 PREDICTED: peroxisomal membrane protein 11C [Tribolium castaneum]>gi|270000949|gb|EEZ97396.1| hypothetical protein TcasGA2_TC011223 [Tribolium castaneum] -- -- -- -- -- K13353 PEX11C peroxin-11C http://www.genome.jp/dbget-bin/www_bget?ko:K13353 Q96HA9 375 2.0e-34 Peroxisomal membrane protein 11C OS=Homo sapiens GN=PEX11G PE=1 SV=1 PF05648//PF07194 Peroxisomal biogenesis factor 11 (PEX11)//P2 response regulator binding domain GO:0006928//GO:0000160//GO:0016559//GO:0016310 movement of cell or subcellular component//phosphorelay signal transduction system//peroxisome fission//phosphorylation GO:0000155//GO:0004673 phosphorelay sensor kinase activity//protein histidine kinase activity GO:0009365//GO:0005779 protein histidine kinase complex//integral component of peroxisomal membrane KOG4186 Peroxisomal biogenesis protein (peroxin) Cluster-8309.58000 BF_2 125.16 2.08 2800 642914595 XP_008190278.1 1870 2.6e-206 PREDICTED: DNA topoisomerase 2-binding protein 1-B isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q800K6 787 4.1e-82 DNA topoisomerase 2-binding protein 1-A OS=Xenopus laevis GN=topbp1-A PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component Cluster-8309.58001 BF_2 7.00 0.64 748 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58002 BF_2 38.22 0.57 3084 642915549 XP_008190662.1 721 5.0e-73 PREDICTED: RNA-binding protein 25 isoform X1 [Tribolium castaneum]>gi|270003846|gb|EFA00294.1| hypothetical protein TcasGA2_TC003127 [Tribolium castaneum] -- -- -- -- -- K12822 RBM25, S164 RNA-binding protein 25 http://www.genome.jp/dbget-bin/www_bget?ko:K12822 P49756 306 2.7e-26 RNA-binding protein 25 OS=Homo sapiens GN=RBM25 PE=1 SV=3 PF00076//PF10579 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Rapsyn N-terminal myristoylation and linker region GO:0006397//GO:0007268 mRNA processing//synaptic transmission GO:0000166//GO:0033130//GO:0003676//GO:0043495 nucleotide binding//acetylcholine receptor binding//nucleic acid binding//protein anchor -- -- KOG2253 U1 snRNP complex, subunit SNU71 and related PWI-motif proteins Cluster-8309.58006 BF_2 56.59 0.32 7609 827556941 XP_012549781.1 1641 2.6e-179 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58007 BF_2 75.13 0.59 5641 827556941 XP_012549781.1 1722 7.7e-189 PREDICTED: uncharacterized protein LOC105842288 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00619 Caspase recruitment domain GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.58018 BF_2 64.21 1.07 2804 91092924 XP_971718.1 2353 2.6e-262 PREDICTED: dynein intermediate chain 3, ciliary [Tribolium castaneum]>gi|270003101|gb|EEZ99548.1| hypothetical protein TcasGA2_TC000130 [Tribolium castaneum] -- -- -- -- -- K11143 DNAI2 dynein intermediate chain 2, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K11143 Q16960 1537 4.5e-169 Dynein intermediate chain 3, ciliary OS=Heliocidaris crassispina PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.58019 BF_2 268.57 2.12 5575 189241146 XP_974291.2 4208 0.0e+00 PREDICTED: phosphatidylinositide phosphatase SAC2 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A8E7C5 1701 8.5e-188 Phosphatidylinositide phosphatase SAC2 OS=Danio rerio GN=inpp5f PE=3 SV=1 PF06056//PF03092//PF02383 Putative ATPase subunit of terminase (gpP-like)//BT1 family//SacI homology domain GO:0019069//GO:0006810 viral capsid assembly//transport GO:0042578//GO:0005524 phosphoric ester hydrolase activity//ATP binding GO:0016021 integral component of membrane KOG1889 Putative phosphoinositide phosphatase Cluster-8309.58025 BF_2 6.92 0.38 1050 189238464 XP_966906.2 645 1.1e-64 PREDICTED: peptidylprolyl isomerase domain and WD repeat-containing protein 1 [Tribolium castaneum] -- -- -- -- -- K12736 PPWD1 peptidylprolyl isomerase domain and WD repeat-containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12736 Q8CEC6 495 1.1e-48 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 OS=Mus musculus GN=Ppwd1 PE=2 SV=2 PF03661//PF00400 Uncharacterised protein family (UPF0121)//WD domain, G-beta repeat -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG0882 Cyclophilin-related peptidyl-prolyl cis-trans isomerase Cluster-8309.58026 BF_2 62.12 1.49 2029 270010956 EFA07404.1 926 5.5e-97 hypothetical protein TcasGA2_TC016387 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O02667 143 1.4e-07 Adenosine receptor A3 OS=Oryctolagus cuniculus GN=ADORA3 PE=2 SV=1 PF00001//PF07127//PF00895 7 transmembrane receptor (rhodopsin family)//Late nodulin protein//ATP synthase protein 8 GO:0015992//GO:0015986//GO:0009878//GO:0007186 proton transport//ATP synthesis coupled proton transport//nodule morphogenesis//G-protein coupled receptor signaling pathway GO:0046872//GO:0015078//GO:0004930 metal ion binding//hydrogen ion transmembrane transporter activity//G-protein coupled receptor activity GO:0000276//GO:0016021 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.58028 BF_2 16.17 0.55 1522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58030 BF_2 152.30 4.11 1837 478257112 ENN77275.1 1264 3.2e-136 hypothetical protein YQE_06102, partial [Dendroctonus ponderosae]>gi|546683352|gb|ERL93174.1| hypothetical protein D910_10471 [Dendroctonus ponderosae] -- -- -- -- -- K11248 SH3GLB endophilin-B http://www.genome.jp/dbget-bin/www_bget?ko:K11248 Q5ZIR1 867 1.4e-91 Endophilin-B1 OS=Gallus gallus GN=SH3GLB1 PE=2 SV=1 PF14604//PF00018//PF03114 Variant SH3 domain//SH3 domain//BAR domain -- -- GO:0005515 protein binding GO:0005737 cytoplasm KOG3725 SH3 domain protein SH3GLB Cluster-8309.58034 BF_2 125.56 2.43 2451 91089169 XP_974055.1 3256 0.0e+00 PREDICTED: vacuolar protein sorting-associated protein 18 homolog isoform X1 [Tribolium castaneum] 642932798 XM_008198766.1 288 8.8306e-147 PREDICTED: Tribolium castaneum vacuolar protein sorting-associated protein 18 homolog (LOC662888), transcript variant X2, mRNA -- -- -- -- P59015 1634 2.2e-180 Vacuolar protein sorting-associated protein 18 homolog OS=Danio rerio GN=vps18 PE=2 SV=2 PF00637//PF13639//PF14634//PF17123//PF17122//PF00097 Region in Clathrin and VPS//Ring finger domain//zinc-RING finger domain//RING-like zinc finger//Zinc-finger//Zinc finger, C3HC4 type (RING finger) GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding -- -- KOG2034 Vacuolar sorting protein PEP3/VPS18 Cluster-8309.58035 BF_2 19.00 0.43 2143 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58039 BF_2 37.78 1.44 1381 91078956 XP_974192.1 730 2.0e-74 PREDICTED: protein prune homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BIW1 423 3.3e-40 Protein prune homolog OS=Mus musculus GN=Prune PE=2 SV=1 PF02833 DHHA2 domain -- -- GO:0016462 pyrophosphatase activity GO:0005737 cytoplasm KOG4129 Exopolyphosphatases and related proteins Cluster-8309.58041 BF_2 69.00 2.48 1453 148469568 ABQ65713.1 843 1.7e-87 encapsulation-relating protein variant a [Anoplophora glabripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.58044 BF_2 45.00 0.31 6286 642939177 XP_969952.3 5007 0.0e+00 PREDICTED: voltage-dependent calcium channel subunit alpha-2/delta-3 [Tribolium castaneum] 642939172 XM_008202143.1 79 3.47449e-30 PREDICTED: Tribolium castaneum uncharacterized LOC103314901 (LOC103314901), transcript variant X1, mRNA K05316 CACNA2DN voltage-dependent calcium channel alpha-2/delta, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05316 Q7Z3S7 1454 4.2e-159 Voltage-dependent calcium channel subunit alpha-2/delta-4 OS=Homo sapiens GN=CACNA2D4 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2353 L-type voltage-dependent Ca2+ channel, alpha2/delta subunit Cluster-8309.58050 BF_2 100.00 1.80 2612 270002008 EEZ98455.1 2345 2.0e-261 hypothetical protein TcasGA2_TC000945 [Tribolium castaneum] 642913296 XM_970406.2 606 0 PREDICTED: Tribolium castaneum vesicular acetylcholine transporter (LOC664399), mRNA K14636 SLC18A3, VACHT MFS transporter, DHA1 family, solute carrier family 18 (vesicular acetylcholine transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K14636 O17444 1915 6.1e-213 Vesicular acetylcholine transporter OS=Drosophila melanogaster GN=VAChT PE=2 SV=2 PF07690//PF09905 Major Facilitator Superfamily//Uncharacterized conserved protein (DUF2132) GO:0055085 transmembrane transport GO:0003677 DNA binding GO:0016021 integral component of membrane KOG3764 Vesicular amine transporter Cluster-8309.58062 BF_2 33.06 1.15 1487 91080811 XP_970116.1 826 1.6e-85 PREDICTED: ufm1-specific protease 2 [Tribolium castaneum]>gi|270005426|gb|EFA01874.1| hypothetical protein TcasGA2_TC007479 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2M1D1 413 5.1e-39 Probable Ufm1-specific protease 2 OS=Drosophila pseudoobscura pseudoobscura GN=UFSP2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58068 BF_2 11.00 0.46 1280 34099638 AAQ57129.1 676 3.4e-68 endonuclease and reverse transcriptase-like protein [Bombyx mori] 299560965 GU183031.1 78 2.49126e-30 Scylla paramamosain microsatellite A340 sequence -- -- -- -- -- -- -- -- PF00451 Scorpion short toxin, BmKK2 GO:0009405//GO:0006810 pathogenesis//transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.58072 BF_2 7.58 0.32 1272 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58073 BF_2 11.00 0.59 1062 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58074 BF_2 38.59 2.27 997 478250388 ENN70883.1 872 5.0e-91 hypothetical protein YQE_12288, partial [Dendroctonus ponderosae]>gi|546672880|gb|ERL84603.1| hypothetical protein D910_02031 [Dendroctonus ponderosae] 766925232 XM_011496200.1 64 1.16834e-22 PREDICTED: Ceratosolen solmsi marchali pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial (LOC105359580), transcript variant X2, mRNA K17509 PDPR pyruvate dehydrogenase phosphatase regulatory subunit http://www.genome.jp/dbget-bin/www_bget?ko:K17509 O46504 516 3.9e-51 Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial OS=Bos taurus GN=PDPR PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2844 Dimethylglycine dehydrogenase precursor Cluster-8309.58076 BF_2 5.00 0.49 710 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58079 BF_2 42.31 0.63 3106 728418583 AIY68374.1 1126 5.5e-120 putative pheromone esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- B2D0J5 652 2.1e-66 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF07859 alpha/beta hydrolase fold GO:0008152 metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.58091 BF_2 1.00 0.69 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58093 BF_2 120.24 0.60 8680 642938387 XP_008191049.1 5216 0.0e+00 PREDICTED: serine-protein kinase ATM isoform X1 [Tribolium castaneum]>gi|642938389|ref|XP_008191050.1| PREDICTED: serine-protein kinase ATM isoform X1 [Tribolium castaneum]>gi|642938391|ref|XP_008191051.1| PREDICTED: serine-protein kinase ATM isoform X1 [Tribolium castaneum] -- -- -- -- -- K04728 ATM, TEL1 ataxia telangiectasia mutated family protein http://www.genome.jp/dbget-bin/www_bget?ko:K04728 Q62388 1980 5.9e-220 Serine-protein kinase ATM OS=Mus musculus GN=Atm PE=1 SV=2 PF11640//PF02259//PF02985//PF02260//PF00454 Telomere-length maintenance and DNA damage repair//FAT domain//HEAT repeat//FATC domain//Phosphatidylinositol 3- and 4-kinase GO:0016310//GO:0009069 phosphorylation//serine family amino acid metabolic process GO:0016773//GO:0005515//GO:0004674 phosphotransferase activity, alcohol group as acceptor//protein binding//protein serine/threonine kinase activity -- -- KOG0892 Protein kinase ATM/Tel1, involved in telomere length regulation and DNA repair Cluster-8309.58098 BF_2 5.73 2.38 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58100 BF_2 8.73 0.59 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58105 BF_2 136.32 2.61 2473 642910743 XP_008193390.1 2580 1.1e-288 PREDICTED: tyrosine-protein kinase transmembrane receptor Ror2 [Tribolium castaneum]>gi|270015023|gb|EFA11471.1| hypothetical protein TcasGA2_TC014181 [Tribolium castaneum] 780671162 XM_011696978.1 111 2.2064e-48 PREDICTED: Wasmannia auropunctata tyrosine-protein kinase transmembrane receptor Ror2 (LOC105454395), mRNA K05129 MUSK muscle, skeletal, receptor tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05129 Q8AXY6 1530 2.6e-168 Muscle, skeletal receptor tyrosine protein kinase OS=Gallus gallus GN=MUSK PE=2 SV=1 PF07714//PF00069//PF01392 Protein tyrosine kinase//Protein kinase domain//Fz domain GO:0006468 protein phosphorylation GO:0004713//GO:0005524//GO:0004672//GO:0005515 protein tyrosine kinase activity//ATP binding//protein kinase activity//protein binding -- -- -- -- Cluster-8309.58108 BF_2 13.64 0.96 879 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58113 BF_2 4.25 0.34 809 646707761 KDR14379.1 365 2.5e-32 Magnesium transporter NIPA2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q8N8Q9 299 4.6e-26 Magnesium transporter NIPA2 OS=Homo sapiens GN=NIPA2 PE=2 SV=1 PF05653//PF03030 Magnesium transporter NIPA//Inorganic H+ pyrophosphatase GO:0015693//GO:0015992//GO:0006119 magnesium ion transport//proton transport//oxidative phosphorylation GO:0015095//GO:0004427//GO:0009678 magnesium ion transmembrane transporter activity//inorganic diphosphatase activity//hydrogen-translocating pyrophosphatase activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG2922 Uncharacterized conserved protein Cluster-8309.58115 BF_2 5.00 0.31 965 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58124 BF_2 10.42 1.02 715 642923877 XP_008193910.1 671 7.2e-68 PREDICTED: aristaless isoform X1 [Tribolium castaneum] 543718138 XM_005500258.1 59 4.9725e-20 PREDICTED: Columba livia ALX homeobox 4 (ALX4), mRNA K09452 ARX homeobox protein aristaless-related http://www.genome.jp/dbget-bin/www_bget?ko:K09452 Q06453 405 2.1e-38 Homeobox protein aristaless OS=Drosophila melanogaster GN=al PE=1 SV=2 PF05920//PF00046 Homeobox KN domain//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.58127 BF_2 82.00 0.74 4934 478260655 ENN80352.1 1748 6.5e-192 hypothetical protein YQE_03211, partial [Dendroctonus ponderosae]>gi|546683687|gb|ERL93465.1| hypothetical protein D910_10756 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8R5M3 241 1.5e-18 Leucine-rich repeat-containing protein 15 OS=Rattus norvegicus GN=Lrrc15 PE=2 SV=1 PF07473//PF13855//PF00560 Spasmodic peptide gm9a; conotoxin from Conus species//Leucine rich repeat//Leucine Rich Repeat GO:0009405 pathogenesis GO:0005515 protein binding GO:0005576 extracellular region -- -- Cluster-8309.58129 BF_2 8.00 0.65 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58132 BF_2 225.01 2.03 4934 642923713 XP_008193853.1 5559 0.0e+00 PREDICTED: neuralized-like protein 4 [Tribolium castaneum] -- -- -- -- -- K16777 NEURL4 neuralized-like protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16777 A1L0Y2 2571 9.9e-289 Neuralized-like protein 4 OS=Xenopus tropicalis GN=neurl4 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.58135 BF_2 48.46 0.65 3397 642923713 XP_008193853.1 4473 0.0e+00 PREDICTED: neuralized-like protein 4 [Tribolium castaneum] -- -- -- -- -- K16777 NEURL4 neuralized-like protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K16777 A1L0Y2 2332 3.5e-261 Neuralized-like protein 4 OS=Xenopus tropicalis GN=neurl4 PE=2 SV=1 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG4625 Notch signaling protein Neuralized, Nuez domain Cluster-8309.58136 BF_2 9.21 0.31 1549 270001464 EEZ97911.1 1060 1.2e-112 hypothetical protein TcasGA2_TC000296 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8HYN7 608 1.3e-61 Kv channel-interacting protein 4 OS=Macaca fascicularis GN=KCNIP4 PE=2 SV=1 PF13202//PF00036//PF04434//PF12763//PF13499//PF13833//PF10591//PF13405 EF hand//EF hand//SWIM zinc finger//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain GO:0007165 signal transduction GO:0005515//GO:0005509//GO:0008270 protein binding//calcium ion binding//zinc ion binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.58138 BF_2 13.00 1.12 774 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58141 BF_2 55.19 0.78 3234 642918045 XP_008198993.1 758 2.7e-77 PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|642918047|ref|XP_008198994.1| PREDICTED: choline transporter-like protein 1 [Tribolium castaneum]>gi|270004665|gb|EFA01113.1| hypothetical protein TcasGA2_TC010325 [Tribolium castaneum] -- -- -- -- -- K15377 SLC44A2_4_5 solute carrier family 44 (choline transporter-like protein), member 2/4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15377 Q8VII6 337 7.2e-30 Choline transporter-like protein 1 OS=Rattus norvegicus GN=Slc44a1 PE=1 SV=1 PF05454 Dystroglycan (Dystrophin-associated glycoprotein 1) GO:0007016 cytoskeletal anchoring at plasma membrane -- -- GO:0016010 dystrophin-associated glycoprotein complex KOG1362 Choline transporter-like protein Cluster-8309.58146 BF_2 41.00 2.74 913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58148 BF_2 47.53 0.55 3878 478253799 ENN74091.1 3895 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 2161 2.7e-241 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082 Subtilase family GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.58150 BF_2 47.69 0.45 4735 546683539 ERL93341.1 1537 1.8e-167 hypothetical protein D910_10634 [Dendroctonus ponderosae] -- -- -- -- -- K10641 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 http://www.genome.jp/dbget-bin/www_bget?ko:K10641 Q6UWE0 679 2.3e-69 E3 ubiquitin-protein ligase LRSAM1 OS=Homo sapiens GN=LRSAM1 PE=1 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.58156 BF_2 249.98 2.16 5135 478253546 ENN73864.1 968 1.9e-101 hypothetical protein YQE_09556, partial [Dendroctonus ponderosae]>gi|546685418|gb|ERL94931.1| hypothetical protein D910_12203 [Dendroctonus ponderosae] 66826052 XM_641289.1 39 4.88179e-08 Dictyostelium discoideum AX4 hypothetical protein (DDB_G0269890) mRNA, complete cds K17759 AIBP, nnrE NAD(P)H-hydrate epimerase http://www.genome.jp/dbget-bin/www_bget?ko:K17759 B3N0Q8 786 9.9e-82 NAD(P)H-hydrate epimerase OS=Drosophila ananassae GN=GF19489 PE=3 SV=1 PF02163//PF01529//PF06814 Peptidase family M50//DHHC palmitoyltransferase//Lung seven transmembrane receptor GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0016021 integral component of membrane KOG2585 Uncharacterized conserved protein Cluster-8309.58168 BF_2 136.00 2.42 2640 861490133 XP_012921468.1 578 1.6e-56 PREDICTED: zinc finger protein 560 isoform X3 [Heterocephalus glaber] -- -- -- -- -- -- -- -- -- Q5MCW4 534 8.5e-53 Zinc finger protein 569 OS=Homo sapiens GN=ZNF569 PE=1 SV=1 PF02176//PF00096//PF13465//PF13912 TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.58170 BF_2 46.00 1.14 1973 546679640 ERL90071.1 745 5.2e-76 hypothetical protein D910_07426 [Dendroctonus ponderosae] 91091009 XM_969922.1 150 3.66458e-70 PREDICTED: Tribolium castaneum homeobox protein HMX3 (LOC663892), mRNA K09995 NKX3-2, BAPX1 homeobox protein Nkx-3.2 http://www.genome.jp/dbget-bin/www_bget?ko:K09995 P70061 323 1.9e-28 Homeobox protein Nkx-3.2 OS=Xenopus laevis GN=nkx3-2 PE=2 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.58180 BF_2 1.01 0.86 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58191 BF_2 5.00 1.51 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11799 impB/mucB/samB family C-terminal domain GO:0006281 DNA repair GO:0003684 damaged DNA binding -- -- -- -- Cluster-8309.58192 BF_2 1.00 0.78 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.582 BF_2 2.00 0.39 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5820 BF_2 3.40 0.34 707 859132808 AKO63318.1 652 1.1e-65 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 [Leptinotarsa decemlineata] -- -- -- -- -- K00021 HMGCR hydroxymethylglutaryl-CoA reductase (NADPH) http://www.genome.jp/dbget-bin/www_bget?ko:K00021 P54960 566 4.4e-57 3-hydroxy-3-methylglutaryl-coenzyme A reductase OS=Blattella germanica PE=2 SV=1 PF00368 Hydroxymethylglutaryl-coenzyme A reductase GO:0006694//GO:0055114//GO:0015936 steroid biosynthetic process//oxidation-reduction process//coenzyme A metabolic process GO:0050662//GO:0004420 coenzyme binding//hydroxymethylglutaryl-CoA reductase (NADPH) activity -- -- KOG2480 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase Cluster-8309.58206 BF_2 20.00 3.80 507 1350937 P48855.1 600 8.8e-60 RecName: Full=40S ribosomal protein S14 [Procambarus clarkii]>gi|434787|dbj|BAA03461.1| ribosomal protein [Procambarus clarkii] 194763634 XM_001963902.1 186 8.7183e-91 Drosophila ananassae GF21290 (Dana\GF21290), mRNA K02955 RP-S14e, RPS14 small subunit ribosomal protein S14e http://www.genome.jp/dbget-bin/www_bget?ko:K02955 P48855 600 3.6e-61 40S ribosomal protein S14 OS=Procambarus clarkii GN=RPS14 PE=2 SV=1 PF00411//PF03423 Ribosomal protein S11//Carbohydrate binding domain (family 25) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:2001070 structural constituent of ribosome//starch binding GO:0005840 ribosome KOG0407 40S ribosomal protein S14 Cluster-8309.5821 BF_2 7.00 0.40 1021 91085781 XP_974423.1 738 1.8e-75 PREDICTED: fas apoptotic inhibitory molecule 1 [Tribolium castaneum]>gi|270009996|gb|EFA06444.1| hypothetical protein TcasGA2_TC009326 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R5H8 467 1.9e-45 Fas apoptotic inhibitory molecule 1 OS=Rattus norvegicus GN=Faim PE=2 SV=1 PF06905 Fas apoptotic inhibitory molecule (FAIM1) GO:0043066 negative regulation of apoptotic process -- -- -- -- KOG4352 Fas-mediated apoptosis inhibitor FAIM Cluster-8309.58210 BF_2 148.00 2.44 2829 189237783 XP_976374.2 1310 2.3e-141 PREDICTED: 2',5'-phosphodiesterase 12-like [Tribolium castaneum] -- -- -- -- -- K19612 PDE12 2',5'-phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K19612 Q08DF7 673 6.9e-69 2',5'-phosphodiesterase 12 OS=Bos taurus GN=PDE12 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.58213 BF_2 21.68 0.76 1481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58215 BF_2 9.00 0.92 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58216 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58219 BF_2 15.66 1.13 867 270008897 EFA05345.1 776 5.9e-80 hypothetical protein TcasGA2_TC015509 [Tribolium castaneum] 170028352 XM_001842008.1 81 3.58377e-32 Culex quinquefasciatus conserved hypothetical protein, mRNA -- -- -- -- Q8N6S4 549 5.1e-55 Ankyrin repeat domain-containing protein 13C OS=Homo sapiens GN=ANKRD13C PE=2 SV=2 -- -- -- -- -- -- -- -- KOG0522 Ankyrin repeat protein Cluster-8309.58222 BF_2 7.00 0.37 1086 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58227 BF_2 20.28 0.46 2124 642917564 XP_008191258.1 1843 2.7e-203 PREDICTED: NF-X1-type zinc finger protein NFXL1 [Tribolium castaneum] -- -- -- -- -- K15683 NFXL1, OZFP NF-X1-type zinc finger protein NFXL1 http://www.genome.jp/dbget-bin/www_bget?ko:K15683 Q6ZNB6 1326 9.9e-145 NF-X1-type zinc finger protein NFXL1 OS=Homo sapiens GN=NFXL1 PE=1 SV=2 PF08771//PF01422 Rapamycin binding domain//NF-X1 type zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0003700//GO:0008144 zinc ion binding//transcription factor activity, sequence-specific DNA binding//drug binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG1952 Transcription factor NF-X1, contains NFX-type Zn2+-binding and R3H domains Cluster-8309.58231 BF_2 139.03 2.58 2541 91078782 XP_969464.1 1789 5.9e-197 PREDICTED: differentially expressed in FDCP 8 homolog [Tribolium castaneum]>gi|270004105|gb|EFA00553.1| hypothetical protein TcasGA2_TC003420 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTT9 913 9.2e-97 Differentially expressed in FDCP 8 homolog OS=Drosophila melanogaster GN=CG11534 PE=1 SV=1 PF00130//PF07649 Phorbol esters/diacylglycerol binding domain (C1 domain)//C1-like domain GO:0035556//GO:0055114 intracellular signal transduction//oxidation-reduction process GO:0008270//GO:0046872//GO:0047134 zinc ion binding//metal ion binding//protein-disulfide reductase activity GO:0005622 intracellular KOG1829 Uncharacterized conserved protein, contains C1, PH and RUN domains Cluster-8309.58232 BF_2 119.00 2.52 2265 642927898 XP_973997.3 2097 1.0e-232 PREDICTED: gamma-tubulin complex component 4 [Tribolium castaneum]>gi|270009848|gb|EFA06296.1| hypothetical protein TcasGA2_TC009163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4F8 777 4.8e-81 Gamma-tubulin complex component 4 OS=Mus musculus GN=Tubgcp4 PE=2 SV=2 PF04130 Spc97 / Spc98 family GO:0090063//GO:0000226 positive regulation of microtubule nucleation//microtubule cytoskeleton organization -- -- GO:0015630//GO:0044430//GO:0000922//GO:0005815 microtubule cytoskeleton//cytoskeletal part//spindle pole//microtubule organizing center KOG2065 Gamma-tubulin ring complex protein Cluster-8309.58248 BF_2 40.61 0.41 4482 861616090 KMQ86259.1 2271 1.3e-252 retrovirus-related gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P04146 954 2.9e-101 Copia protein OS=Drosophila melanogaster GN=GIP PE=1 SV=3 PF00665//PF00098//PF13683 Integrase core domain//Zinc knuckle//Integrase core domain GO:0015074 DNA integration GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.5825 BF_2 6.64 0.49 856 642928921 XP_008195617.1 718 3.1e-73 PREDICTED: ubiquitin carboxyl-terminal hydrolase 34 [Tribolium castaneum] -- -- -- -- -- K11853 USP34 ubiquitin carboxyl-terminal hydrolase 34 http://www.genome.jp/dbget-bin/www_bget?ko:K11853 Q6ZQ93 235 1.3e-18 Ubiquitin carboxyl-terminal hydrolase 34 OS=Mus musculus GN=Usp34 PE=1 SV=3 PF07819 PGAP1-like protein GO:0006886//GO:0006505 intracellular protein transport//GPI anchor metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.58252 BF_2 6.00 0.51 781 836700863 XP_012791490.1 150 2.0e-07 PREDICTED: PR domain zinc finger protein 15 [Sorex araneus] -- -- -- -- -- -- -- -- -- P57071 142 7.1e-08 PR domain zinc finger protein 15 OS=Homo sapiens GN=PRDM15 PE=2 SV=4 PF00412//PF13912//PF07975//PF05180//PF00096//PF13465 LIM domain//C2H2-type zinc finger//TFIIH C1-like domain//DNL zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding -- -- KOG1721 FOG: Zn-finger Cluster-8309.58255 BF_2 69.19 0.41 7365 642936143 XP_975059.2 608 1.5e-59 PREDICTED: muscle segmentation homeobox [Tribolium castaneum] 198449863 XM_001357713.2 102 6.67477e-43 Drosophila pseudoobscura pseudoobscura GA15116 (Dpse\GA15116), partial mRNA K09341 MSX homeobox protein MSX http://www.genome.jp/dbget-bin/www_bget?ko:K09341 Q03372 434 9.3e-41 Muscle segmentation homeobox OS=Drosophila melanogaster GN=Dr PE=2 SV=2 PF02914 Bacteriophage Mu transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0004803//GO:0003677 transposase activity//DNA binding -- -- KOG0492 Transcription factor MSH, contains HOX domain Cluster-8309.58256 BF_2 145.81 1.45 4483 642936143 XP_975059.2 1125 1.0e-119 PREDICTED: muscle segmentation homeobox [Tribolium castaneum] 198449863 XM_001357713.2 102 4.05186e-43 Drosophila pseudoobscura pseudoobscura GA15116 (Dpse\GA15116), partial mRNA K09341 MSX homeobox protein MSX http://www.genome.jp/dbget-bin/www_bget?ko:K09341 Q03372 541 2.2e-53 Muscle segmentation homeobox OS=Drosophila melanogaster GN=Dr PE=2 SV=2 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0492 Transcription factor MSH, contains HOX domain Cluster-8309.58267 BF_2 17.88 0.31 2725 270007722 EFA04170.1 1567 3.5e-171 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TZZ7 794 6.2e-83 Extended synaptotagmin-2 OS=Mus musculus GN=Esyt2 PE=1 SV=1 PF17047//PF00168 Synaptotagmin-like mitochondrial-lipid-binding domain//C2 domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.58269 BF_2 81.00 2.18 1842 642938000 XP_008199165.1 419 3.1e-38 PREDICTED: uncharacterized protein LOC103314560 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O97148 178 1.1e-11 G-protein coupled receptor Mth OS=Drosophila melanogaster GN=mth PE=1 SV=1 PF06652//PF00002 Methuselah N-terminus//7 transmembrane receptor (Secretin family) GO:0006950//GO:0007186 response to stress//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.58274 BF_2 5.00 0.52 687 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58277 BF_2 2.00 0.75 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58278 BF_2 3.00 0.98 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58284 BF_2 3.00 0.42 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58293 BF_2 5.00 0.68 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58299 BF_2 170.00 3.79 2163 332374866 AEE62574.1 1742 1.4e-191 unknown [Dendroctonus ponderosae] -- -- -- -- -- K00972 UAP1 UDP-N-acetylglucosamine/UDP-N-acetylgalactosamine diphosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00972 Q91YN5 1254 2.3e-136 UDP-N-acetylhexosamine pyrophosphorylase OS=Mus musculus GN=Uap1 PE=1 SV=1 PF01513//PF01704 ATP-NAD kinase//UTP--glucose-1-phosphate uridylyltransferase GO:0046497//GO:0006769//GO:0006741//GO:0008152 nicotinate nucleotide metabolic process//nicotinamide metabolic process//NADP biosynthetic process//metabolic process GO:0070569//GO:0003951 uridylyltransferase activity//NAD+ kinase activity -- -- KOG2388 UDP-N-acetylglucosamine pyrophosphorylase Cluster-8309.58300 BF_2 3.00 0.68 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58301 BF_2 41.61 0.67 2872 642936911 XP_008194442.1 3085 0.0e+00 PREDICTED: PHD finger protein 14 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D4H9 1117 2.3e-120 PHD finger protein 14 OS=Mus musculus GN=Phf14 PE=1 SV=1 PF00130//PF01017//PF06156//PF00628//PF02059 Phorbol esters/diacylglycerol binding domain (C1 domain)//STAT protein, all-alpha domain//Protein of unknown function (DUF972)//PHD-finger//Interleukin-3 GO:0035556//GO:0006355//GO:0006260//GO:0006955//GO:0008283//GO:0040007//GO:0007165 intracellular signal transduction//regulation of transcription, DNA-templated//DNA replication//immune response//cell proliferation//growth//signal transduction GO:0003700//GO:0004871//GO:0005515//GO:0005135//GO:0008083 transcription factor activity, sequence-specific DNA binding//signal transducer activity//protein binding//interleukin-3 receptor binding//growth factor activity GO:0005576//GO:0005894//GO:0005667 extracellular region//interleukin-3 receptor complex//transcription factor complex KOG0957 PHD finger protein Cluster-8309.58305 BF_2 201.25 2.34 3891 91082901 XP_972219.1 678 6.1e-68 PREDICTED: zinc finger CCHC domain-containing protein 8 homolog [Tribolium castaneum]>gi|270007610|gb|EFA04058.1| hypothetical protein TcasGA2_TC014291 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2PE14 512 4.4e-50 Zinc finger CCHC domain-containing protein 8 homolog OS=Drosophila melanogaster GN=CG4622 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2673 Uncharacterized conserved protein, contains PSP domain Cluster-8309.58307 BF_2 55.75 1.03 2548 270009116 EFA05564.1 1984 1.4e-219 hypothetical protein TcasGA2_TC015753 [Tribolium castaneum] 642926575 XM_008196705.1 163 2.8197e-77 PREDICTED: Tribolium castaneum putative fatty acyl-CoA reductase CG5065 (LOC656109), mRNA K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 1034 8.6e-111 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01118//PF01073//PF03015 NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0051287//GO:0016616//GO:0003854//GO:0050662//GO:0003824//GO:0016620//GO:0080019 NAD binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//coenzyme binding//catalytic activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.58308 BF_2 21.00 0.64 1657 642932711 XP_008196956.1 648 7.8e-65 PREDICTED: uncharacterized protein LOC103314018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58309 BF_2 2.00 0.40 496 642932711 XP_008196956.1 248 5.6e-19 PREDICTED: uncharacterized protein LOC103314018 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58314 BF_2 61.66 1.61 1885 91090914 XP_974006.1 2116 5.3e-235 PREDICTED: NCK-interacting protein with SH3 domain [Tribolium castaneum]>gi|270013220|gb|EFA09668.1| hypothetical protein TcasGA2_TC011794 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9ESJ4 782 1.1e-81 NCK-interacting protein with SH3 domain OS=Mus musculus GN=Nckipsd PE=2 SV=2 PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- KOG4035 Coeffector of mDia Rho GTPase, regulates actin polymerization and cell adhesion turnover Cluster-8309.58316 BF_2 48.15 0.83 2706 642920697 XP_008192527.1 405 1.9e-36 PREDICTED: mucin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58318 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58323 BF_2 66.87 2.97 1229 91076372 XP_967795.1 1324 2.4e-143 PREDICTED: palmitoyltransferase ZDHHC6 [Tribolium castaneum] 871251020 XM_005104281.2 41 8.83977e-10 PREDICTED: Aplysia californica palmitoyltransferase ZDHHC6-like (LOC101847980), transcript variant X2, mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q9CPV7 758 4.2e-79 Palmitoyltransferase ZDHHC6 OS=Mus musculus GN=Zdhhc6 PE=2 SV=1 PF01363//PF01529 FYVE zinc finger//DHHC palmitoyltransferase -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding -- -- KOG1314 DHHC-type Zn-finger protein Cluster-8309.58324 BF_2 3.00 1.03 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58325 BF_2 329.38 5.11 2982 91077428 XP_975436.1 1252 1.3e-134 PREDICTED: tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A [Tribolium castaneum]>gi|270001628|gb|EEZ98075.1| hypothetical protein TcasGA2_TC000482 [Tribolium castaneum] -- -- -- -- -- K07442 TRM61, GCD14 tRNA (adenine57-N1/adenine58-N1)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K07442 A6H791 696 1.6e-71 tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A OS=Bos taurus GN=TRMT61A PE=2 SV=1 PF08704//PF01135//PF06816//PF03009 tRNA methyltransferase complex GCD14 subunit//Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//NOTCH protein//Glycerophosphoryl diester phosphodiesterase family GO:0030488//GO:0006629//GO:0006464//GO:0046500//GO:0008033//GO:0030154//GO:0006479//GO:0009451 tRNA methylation//lipid metabolic process//cellular protein modification process//S-adenosylmethionine metabolic process//tRNA processing//cell differentiation//protein methylation//RNA modification GO:0016429//GO:0008081//GO:0004719 tRNA (adenine-N1-)-methyltransferase activity//phosphoric diester hydrolase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity GO:0016021//GO:0031515 integral component of membrane//tRNA (m1A) methyltransferase complex KOG2915 tRNA(1-methyladenosine) methyltransferase, subunit GCD14 Cluster-8309.58328 BF_2 16.21 0.51 1605 642927459 XP_968905.2 1151 3.6e-123 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q14914 756 9.3e-79 Prostaglandin reductase 1 OS=Homo sapiens GN=PTGR1 PE=1 SV=2 PF00107//PF01370//PF01118//PF00208 Zinc-binding dehydrogenase//NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016620//GO:0016491//GO:0051287//GO:0003824//GO:0050662 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//oxidoreductase activity//NAD binding//catalytic activity//coenzyme binding -- -- KOG1196 Predicted NAD-dependent oxidoreductase Cluster-8309.58330 BF_2 12.96 0.57 1241 -- -- -- -- -- 262401228 FJ774796.1 572 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.58337 BF_2 1.98 0.71 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58339 BF_2 4.00 0.41 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58343 BF_2 2.00 0.50 453 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58344 BF_2 95.66 3.64 1387 332374692 AEE62487.1 751 7.4e-77 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8QZW3 348 1.6e-31 Protein FAM151A OS=Mus musculus GN=Fam151a PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58345 BF_2 24.53 2.37 720 642910891 XP_972272.3 724 5.2e-74 PREDICTED: SLIT-ROBO Rho GTPase-activating protein 1-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K07526 SRGAP SLIT-ROBO Rho GTPase activating protein http://www.genome.jp/dbget-bin/www_bget?ko:K07526 B0S6J3 269 1.2e-22 SLIT-ROBO Rho GTPase-activating protein 2 OS=Danio rerio GN=srgap2 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58346 BF_2 15.56 0.42 1848 -- -- -- -- -- 338224420 HM217854.1 217 1.94973e-107 Scylla paramamosain retinitis pigmentosa GTPase regulator-like protein-like protein-like mRNA, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58349 BF_2 4.00 0.36 758 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00873 AcrB/AcrD/AcrF family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.58352 BF_2 9.55 0.71 853 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58354 BF_2 1.46 0.53 400 478254560 ENN74803.1 347 1.5e-30 hypothetical protein YQE_08576, partial [Dendroctonus ponderosae]>gi|546681652|gb|ERL91703.1| hypothetical protein D910_09030 [Dendroctonus ponderosae] -- -- -- -- -- K19219 JMJD7 jumonji domain-containing protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K19219 P0C872 266 1.5e-22 JmjC domain-containing protein 7 OS=Mus musculus GN=Jmjd7 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2508 Predicted phospholipase Cluster-8309.58355 BF_2 97.68 0.88 4930 478259242 ENN79144.1 1222 6.4e-131 hypothetical protein YQE_04330, partial [Dendroctonus ponderosae]>gi|546678424|gb|ERL89047.1| hypothetical protein D910_06425 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VGY6 914 1.4e-96 Protein Skeletor, isoforms B/C OS=Drosophila melanogaster GN=Skeletor PE=1 SV=2 PF11606 Family 31 carbohydrate binding protein -- -- GO:0033905 xylan endo-1,3-beta-xylosidase activity -- -- -- -- Cluster-8309.58362 BF_2 3.00 0.40 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58364 BF_2 30.70 0.38 3666 642934335 XP_969733.2 2984 0.0e+00 PREDICTED: tripartite motif-containing protein 2 isoform X5 [Tribolium castaneum] 817086197 XM_012410395.1 92 1.19802e-37 PREDICTED: Athalia rosae tripartite motif-containing protein 2-like (LOC105691712), mRNA K11997 TRIM2_3 tripartite motif-containing protein 2/3 http://www.genome.jp/dbget-bin/www_bget?ko:K11997 A4IF63 448 1.1e-42 Tripartite motif-containing protein 2 OS=Bos taurus GN=TRIM2 PE=2 SV=1 PF02601//PF01580//PF13639//PF05149//PF01637//PF09815//PF05524//PF01436//PF00643//PF14634//PF00097//PF05929 Exonuclease VII, large subunit//FtsK/SpoIIIE family//Ring finger domain//Paraflagellar rod protein//Archaeal ATPase//XK-related protein//PEP-utilising enzyme, N-terminal//NHL repeat//B-box zinc finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Phage capsid scaffolding protein (GPO) serine peptidase GO:0006308//GO:0019069//GO:0009401 DNA catabolic process//viral capsid assembly//phosphoenolpyruvate-dependent sugar phosphotransferase system GO:0005515//GO:0008855//GO:0003677//GO:0005516//GO:0005524//GO:0046872//GO:0008270//GO:0000166 protein binding//exodeoxyribonuclease VII activity//DNA binding//calmodulin binding//ATP binding//metal ion binding//zinc ion binding//nucleotide binding GO:0031514//GO:0016021//GO:0005622//GO:0009318 motile cilium//integral component of membrane//intracellular//exodeoxyribonuclease VII complex -- -- Cluster-8309.58366 BF_2 83.00 6.34 835 91093337 XP_976060.1 141 2.4e-06 PREDICTED: uncharacterized protein LOC655475 [Tribolium castaneum]>gi|270015235|gb|EFA11683.1| hypothetical protein TcasGA2_TC008547 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58373 BF_2 19.96 0.64 1597 270011132 EFA07580.1 1336 1.3e-144 hypothetical protein TcasGA2_TC016363 [Tribolium castaneum]>gi|485836803|tpg|DAA64486.1| TPA_inf: G protein-coupled receptor Tc 45 [Tribolium castaneum] -- -- -- -- -- K04226 AVPR1A arginine vasopressin receptor 1A http://www.genome.jp/dbget-bin/www_bget?ko:K04226 Q7YW31 649 2.4e-66 Cephalotocin receptor 1 OS=Octopus vulgaris GN=CTR1 PE=2 SV=1 PF09446//PF00001 VMA21-like domain//7 transmembrane receptor (rhodopsin family) GO:0070072//GO:0007186 vacuolar proton-transporting V-type ATPase complex assembly//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.5838 BF_2 40.25 1.08 1848 478251528 ENN71990.1 1497 3.1e-163 hypothetical protein YQE_11281, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9H8E8 659 1.9e-67 Cysteine-rich protein 2-binding protein OS=Homo sapiens GN=CSRP2BP PE=1 SV=3 PF00583//PF13508//PF08445//PF13673//PF02576//PF00130//PF00628//PF16866 Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Putative ribosome maturation factor RimP//Phorbol esters/diacylglycerol binding domain (C1 domain)//PHD-finger//PHD-finger GO:0042274//GO:0042967//GO:0035556 ribosomal small subunit biogenesis//acyl-carrier-protein biosynthetic process//intracellular signal transduction GO:0016747//GO:0005515//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//protein binding//N-acetyltransferase activity -- -- -- -- Cluster-8309.58384 BF_2 27.45 2.68 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58388 BF_2 75.60 2.02 1850 478257462 ENN77618.1 921 1.9e-96 hypothetical protein YQE_05913, partial [Dendroctonus ponderosae]>gi|546679856|gb|ERL90244.1| hypothetical protein D910_07597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBW5 222 8.9e-17 Zinc finger HIT domain-containing protein 2 OS=Bos taurus GN=ZNHIT2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4317 Predicted Zn-finger protein Cluster-8309.58389 BF_2 116.40 3.16 1829 478257462 ENN77618.1 921 1.9e-96 hypothetical protein YQE_05913, partial [Dendroctonus ponderosae]>gi|546679856|gb|ERL90244.1| hypothetical protein D910_07597 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q2TBW5 222 8.8e-17 Zinc finger HIT domain-containing protein 2 OS=Bos taurus GN=ZNHIT2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4317 Predicted Zn-finger protein Cluster-8309.58390 BF_2 1.00 0.51 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58398 BF_2 28.73 0.43 3078 642928968 XP_008195638.1 212 5.2e-14 PREDICTED: FK506-binding protein 5-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05932 Tir chaperone protein (CesT) family GO:0050708 regulation of protein secretion -- -- GO:0005737 cytoplasm -- -- Cluster-8309.58400 BF_2 155.00 4.12 1860 642927549 XP_971699.2 801 1.6e-82 PREDICTED: single-strand selective monofunctional uracil DNA glycosylase [Tribolium castaneum] -- -- -- -- -- K10800 SMUG1 single-strand selective monofunctional uracil DNA glycosylase http://www.genome.jp/dbget-bin/www_bget?ko:K10800 Q9YGN6 564 2.0e-56 Single-strand selective monofunctional uracil DNA glycosylase OS=Xenopus laevis GN=smug1 PE=1 SV=1 PF00383//PF08210 Cytidine and deoxycytidylate deaminase zinc-binding region//APOBEC-like N-terminal domain GO:0006807 nitrogen compound metabolic process GO:0016814//GO:0008270 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines//zinc ion binding -- -- KOG1018 Cytosine deaminase FCY1 and related enzymes Cluster-8309.58403 BF_2 119.44 3.56 1690 642918258 XP_008191434.1 1452 4.7e-158 PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918260|ref|XP_008191435.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum]>gi|642918262|ref|XP_008191436.1| PREDICTED: dual oxidase maturation factor 1 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 Q1HG43 346 3.4e-31 Dual oxidase maturation factor 1 OS=Homo sapiens GN=DUOXA1 PE=1 SV=1 PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0005789//GO:0016021 endoplasmic reticulum membrane//integral component of membrane KOG3921 Uncharacterized conserved protein Cluster-8309.58404 BF_2 3.76 0.37 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58406 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58410 BF_2 67.00 0.56 5262 761263427 AJP36493.1 2253 1.9e-250 nicotinic acetylcholine receptor alpha 7 [Leptinotarsa decemlineata] 158262732 NM_001109950.1 450 0 Tribolium castaneum nicotinic acetylcholine receptor alpha 7 subunit (nAChRa7), mRNA >gnl|BL_ORD_ID|4646358 Tribolium castaneum nicotinic acetylcholine receptor subunit alpha7 mRNA, complete cds K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P48180 1064 5.9e-114 Acetylcholine receptor subunit alpha-type acr-16 OS=Caenorhabditis elegans GN=acr-16 PE=2 SV=1 PF02931//PF02932 Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3646 Acetylcholine receptor Cluster-8309.58412 BF_2 102.40 1.14 4037 270006253 EFA02701.1 3335 0.0e+00 hypothetical protein TcasGA2_TC008423 [Tribolium castaneum] 3511174 AF064514.1 390 0 AF064514 Manduca sexta soluble guanylyl cyclase beta-3 mRNA, complete cds K01769 E4.6.1.2 guanylate cyclase, other http://www.genome.jp/dbget-bin/www_bget?ko:K01769 Q8INF0 2650 5.6e-298 Soluble guanylate cyclase 88E OS=Drosophila melanogaster GN=Gyc88E PE=1 SV=3 PF00211//PF07700//PF07701 Adenylate and Guanylate cyclase catalytic domain//Haem-NO-binding//Heme NO binding associated GO:0006182//GO:0046039//GO:0006144//GO:0035556//GO:0009190 cGMP biosynthetic process//GTP metabolic process//purine nucleobase metabolic process//intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0004383//GO:0020037//GO:0016849 guanylate cyclase activity//heme binding//phosphorus-oxygen lyase activity -- -- KOG4171 Adenylate/guanylate kinase Cluster-8309.58415 BF_2 48.52 0.77 2938 795012910 XP_011880473.1 1507 3.4e-164 PREDICTED: uncharacterized protein LOC105568978 [Vollenhovia emeryi]>gi|795012913|ref|XP_011880481.1| PREDICTED: uncharacterized protein LOC105568978 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699//PF01480 hAT family C-terminal dimerisation region//PWI domain GO:0006397 mRNA processing GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.58422 BF_2 63.25 0.76 3775 564248485 XP_006263331.1 699 2.2e-70 PREDICTED: zinc finger protein 850-like [Alligator mississippiensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 660 3.0e-67 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF16622//PF01428//PF13912//PF02892//PF13465//PF07776//PF06467//PF04858//PF01155//PF00130//PF02176//PF00096 zinc-finger C2H2-type//AN1-like Zinc finger//C2H2-type zinc finger//BED zinc finger//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//MYM-type Zinc finger with FCS sequence motif//TH1 protein//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Phorbol esters/diacylglycerol binding domain (C1 domain)//TRAF-type zinc finger//Zinc finger, C2H2 type GO:0006464//GO:0035556//GO:0045892 cellular protein modification process//intracellular signal transduction//negative regulation of transcription, DNA-templated GO:0016151//GO:0003677//GO:0046872//GO:0008270 nickel cation binding//DNA binding//metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.58424 BF_2 2.00 0.31 557 357603879 EHJ63960.1 208 2.7e-14 transposase [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58427 BF_2 74.00 3.15 1270 91087937 XP_971924.1 1053 6.5e-112 PREDICTED: alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 [Tribolium castaneum]>gi|270011936|gb|EFA08384.1| hypothetical protein TcasGA2_TC006028 [Tribolium castaneum] -- -- -- -- -- K10766 ALKBH4 alkylated DNA repair protein alkB homolog 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10766 Q9D8F1 548 9.7e-55 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 OS=Mus musculus GN=Alkbh4 PE=2 SV=1 PF03171 2OG-Fe(II) oxygenase superfamily GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3959 2-Oxoglutarate- and iron-dependent dioxygenase-related proteins Cluster-8309.58431 BF_2 14.01 0.41 1705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58437 BF_2 14.00 0.72 1105 294938638 XP_002782134.1 172 8.2e-10 microneme protein 12, putative [Perkinsus marinus ATCC 50983]>gi|239893612|gb|EER13929.1| microneme protein 12, putative [Perkinsus marinus ATCC 50983] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58439 BF_2 4.00 0.45 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5844 BF_2 16.19 0.41 1936 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58443 BF_2 37.00 2.07 1034 546683188 ERL93032.1 509 6.4e-49 hypothetical protein D910_10334 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498//PF12844//PF01381 Transposase//Helix-turn-helix domain//Helix-turn-helix GO:0015074//GO:0006313 DNA integration//transposition, DNA-mediated GO:0003677//GO:0043565 DNA binding//sequence-specific DNA binding -- -- -- -- Cluster-8309.58444 BF_2 47.00 2.80 989 861631908 KMQ90492.1 544 5.3e-53 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58454 BF_2 89.09 1.64 2559 167234455 NP_001107843.1 1160 5.1e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.4e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58455 BF_2 32.46 0.53 2850 167234455 NP_001107843.1 1160 5.7e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 2.6e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58459 BF_2 33.00 3.96 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168 Triple QxxK/R motif-containing protein family -- -- -- -- GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.58460 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58470 BF_2 7.00 0.57 801 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58471 BF_2 16.56 0.32 2471 642934956 XP_008195951.1 2024 3.2e-224 PREDICTED: TNF receptor-associated factor 4 isoform X3 [Tribolium castaneum] 817199300 XM_012419904.1 272 6.98106e-138 PREDICTED: Orussus abietinus TNF receptor-associated factor 4 (LOC105696990), transcript variant X2, mRNA K09848 TRAF4 TNF receptor-associated factor 4 http://www.genome.jp/dbget-bin/www_bget?ko:K09848 Q61382 1173 6.3e-127 TNF receptor-associated factor 4 OS=Mus musculus GN=Traf4 PE=1 SV=2 PF03145//PF05320//PF15965//PF02176//PF00096 Seven in absentia protein family//Poxvirus DNA-directed RNA polymerase 19 kDa subunit//TRAF-like zinc-finger//TRAF-type zinc finger//Zinc finger, C2H2 type GO:0006144//GO:0007275//GO:0006351//GO:0006206//GO:0006511 purine nucleobase metabolic process//multicellular organismal development//transcription, DNA-templated//pyrimidine nucleobase metabolic process//ubiquitin-dependent protein catabolic process GO:0003677//GO:0003899//GO:0046872//GO:0008270 DNA binding//DNA-directed RNA polymerase activity//metal ion binding//zinc ion binding GO:0005634//GO:0005730 nucleus//nucleolus KOG0297 TNF receptor-associated factor Cluster-8309.58473 BF_2 5.00 0.47 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02444 Hepatitis E virus ORF-2 (Putative capsid protein) -- -- -- -- GO:0030430 host cell cytoplasm -- -- Cluster-8309.58474 BF_2 18.00 2.22 627 768408833 XP_011549482.1 175 2.1e-10 PREDICTED: endocuticle structural glycoprotein ABD-4-like [Plutella xylostella] -- -- -- -- -- -- -- -- -- Q7M4F4 148 1.2e-08 Endocuticle structural glycoprotein SgAbd-1 OS=Schistocerca gregaria PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.58476 BF_2 13.00 0.63 1150 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58485 BF_2 4.00 0.83 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58487 BF_2 152.94 1.99 3507 642927046 XP_008195117.1 1375 8.3e-149 PREDICTED: putative ATP-dependent RNA helicase DHX30 isoform X1 [Tribolium castaneum] -- -- -- -- -- K13185 DHX30 ATP-dependent RNA helicase DHX30 http://www.genome.jp/dbget-bin/www_bget?ko:K13185 Q5ZI74 649 5.2e-66 Putative ATP-dependent RNA helicase DHX30 OS=Gallus gallus GN=DHX30 PE=2 SV=1 PF00270//PF03193//PF04408 DEAD/DEAH box helicase//Protein of unknown function, DUF258//Helicase associated domain (HA2) -- -- GO:0003924//GO:0003676//GO:0005524//GO:0005525//GO:0004386 GTPase activity//nucleic acid binding//ATP binding//GTP binding//helicase activity -- -- KOG0920 ATP-dependent RNA helicase A Cluster-8309.58488 BF_2 62.30 0.75 3783 642921031 XP_008192662.1 1730 6.1e-190 PREDICTED: harmonin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ0 398 7.2e-37 Harmonin OS=Bos taurus GN=USH1C PE=2 SV=1 PF00595//PF13180//PF01402//PF02517 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Ribbon-helix-helix protein, copG family//CAAX protease self-immunity GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.58497 BF_2 366.17 8.78 2032 642922539 XP_008193217.1 1116 5.2e-119 PREDICTED: alpha-tocopherol transfer protein-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IUQ0 426 2.2e-40 Clavesin-1 OS=Homo sapiens GN=CLVS1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58502 BF_2 20.26 0.32 2915 189241581 XP_969604.2 2442 1.3e-272 PREDICTED: phosphoinositide 3-kinase adapter protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9DDT2 256 1.6e-20 Phosphoinositide 3-kinase adapter protein 1 OS=Gallus gallus GN=PIK3AP1 PE=1 SV=1 PF04136 Sec34-like family GO:0006886 intracellular protein transport -- -- GO:0016020//GO:0005801 membrane//cis-Golgi network -- -- Cluster-8309.58505 BF_2 15.69 0.31 2403 357615315 EHJ69593.1 528 9.3e-51 hypothetical protein KGM_08876 [Danaus plexippus] -- -- -- -- -- -- -- -- -- Q60934 431 6.8e-41 Glutamate receptor ionotropic, kainate 1 OS=Mus musculus GN=Grik1 PE=2 SV=2 PF00862//PF10613 Sucrose synthase//Ligated ion channel L-glutamate- and glycine-binding site GO:0006811//GO:0005982//GO:0007165//GO:0005985//GO:0007268 ion transport//starch metabolic process//signal transduction//sucrose metabolic process//synaptic transmission GO:0005234//GO:0016157//GO:0004970 extracellular-glutamate-gated ion channel activity//sucrose synthase activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.58507 BF_2 44.57 1.60 1451 642922431 XP_008193164.1 1068 1.4e-113 PREDICTED: gustatory receptor Gr83 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 988 1.1e-105 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1440 CDP-diacylglycerol synthase Cluster-8309.58508 BF_2 70.43 2.29 1572 642922431 XP_008193164.1 1068 1.5e-113 PREDICTED: gustatory receptor Gr83 isoform X2 [Tribolium castaneum] -- -- -- -- -- K00981 E2.7.7.41, CDS1, CDS2, cdsA phosphatidate cytidylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00981 P56079 988 1.1e-105 Phosphatidate cytidylyltransferase, photoreceptor-specific OS=Drosophila melanogaster GN=CdsA PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1440 CDP-diacylglycerol synthase Cluster-8309.58514 BF_2 17.26 0.42 1988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58519 BF_2 26.00 1.33 1107 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58524 BF_2 3.16 1.15 401 270016638 EFA13084.1 139 2.0e-06 hypothetical protein TcasGA2_TC011584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06467//PF02892 MYM-type Zinc finger with FCS sequence motif//BED zinc finger -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- -- -- Cluster-8309.58525 BF_2 49.01 3.06 957 270016638 EFA13084.1 140 3.6e-06 hypothetical protein TcasGA2_TC011584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF06467 BED zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- -- -- Cluster-8309.58527 BF_2 33.00 0.65 2396 91087671 XP_976426.1 247 3.6e-18 PREDICTED: vitelline membrane protein Vm26Ab isoform X1 [Tribolium castaneum]>gi|270010717|gb|EFA07165.1| hypothetical protein TcasGA2_TC010163 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58531 BF_2 59.00 0.36 7170 642929979 XP_008196051.1 1519 3.4e-165 PREDICTED: centromere-associated protein E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q02224 485 1.1e-46 Centromere-associated protein E OS=Homo sapiens GN=CENPE PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58540 BF_2 4.00 0.60 568 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58549 BF_2 117.44 1.92 2852 546683323 ERL93150.1 828 1.8e-85 hypothetical protein D910_10448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q96PX9 360 1.4e-32 Pleckstrin homology domain-containing family G member 4B OS=Homo sapiens GN=PLEKHG4B PE=2 SV=4 PF01825//PF00621 GPCR proteolysis site, GPS, motif//RhoGEF domain GO:0035023//GO:0043087 regulation of Rho protein signal transduction//regulation of GTPase activity GO:0005089 Rho guanyl-nucleotide exchange factor activity GO:0016020 membrane -- -- Cluster-8309.58558 BF_2 210.71 2.31 4111 189239721 XP_967180.2 687 5.8e-69 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 377 2.1e-34 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF04921//PF00320 XAP5, circadian clock regulator//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.5856 BF_2 1.00 2.11 283 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58561 BF_2 48.82 0.52 4185 189239721 XP_967180.2 687 5.9e-69 PREDICTED: GATA zinc finger domain-containing protein 1 [Tribolium castaneum]>gi|270010752|gb|EFA07200.1| hypothetical protein TcasGA2_TC010207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8WUU5 377 2.2e-34 GATA zinc finger domain-containing protein 1 OS=Homo sapiens GN=GATAD1 PE=1 SV=1 PF04921//PF00320 XAP5, circadian clock regulator//GATA zinc finger GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634 transcription factor complex//nucleus -- -- Cluster-8309.58568 BF_2 32.42 0.36 4064 642921033 XP_008192663.1 1730 6.6e-190 PREDICTED: harmonin isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3MHQ0 398 7.7e-37 Harmonin OS=Bos taurus GN=USH1C PE=2 SV=1 PF01402//PF02517//PF13180//PF00595 Ribbon-helix-helix protein, copG family//CAAX protease self-immunity//PDZ domain//PDZ domain (Also known as DHR or GLGF) GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.58569 BF_2 41.72 1.34 1585 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58571 BF_2 3.00 0.66 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58575 BF_2 14.91 2.64 523 546684343 ERL94048.1 160 9.4e-09 hypothetical protein D910_11331 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58591 BF_2 57.22 0.76 3433 815896315 XP_012246840.1 694 7.5e-70 PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896317|ref|XP_012246847.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens]>gi|815896319|ref|XP_012246857.1| PREDICTED: sulfotransferase 4A1 [Bombus impatiens] -- -- -- -- -- -- -- -- -- P19217 395 1.4e-36 Estrogen sulfotransferase OS=Bos taurus GN=SULT1E1 PE=1 SV=1 PF00685 Sulfotransferase domain -- -- GO:0008146 sulfotransferase activity -- -- -- -- Cluster-8309.58592 BF_2 40.35 0.44 4121 642939403 XP_008193263.1 1963 6.4e-217 PREDICTED: protein FAM135A [Tribolium castaneum]>gi|270016463|gb|EFA12909.1| hypothetical protein TcasGA2_TC006979 [Tribolium castaneum] 642939402 XM_008195041.1 369 0 PREDICTED: Tribolium castaneum protein FAM135A (LOC661082), mRNA -- -- -- -- Q5RA75 1083 2.9e-116 Protein FAM135A OS=Pongo abelii GN=FAM135A PE=2 SV=1 PF07819 PGAP1-like protein GO:0006886//GO:0006505 intracellular protein transport//GPI anchor metabolic process GO:0016788 hydrolase activity, acting on ester bonds -- -- KOG2205 Uncharacterized conserved protein Cluster-8309.58595 BF_2 45.00 1.95 1254 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58604 BF_2 64.00 2.00 1625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58606 BF_2 5.00 0.38 838 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58614 BF_2 31.00 0.76 1983 642923075 XP_008193601.1 906 1.1e-94 PREDICTED: uncharacterized protein LOC655361 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VBV3 176 2.1e-11 Protein takeout OS=Drosophila melanogaster GN=to PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58626 BF_2 41.00 9.85 461 765339464 XP_011493633.1 161 6.4e-09 AAEL017179-PA [Aedes aegypti]>gi|403183234|gb|EJY57947.1| AAEL017179-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- D2WKD9 126 3.0e-06 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF12242//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.58632 BF_2 106.07 2.49 2071 642933652 XP_975152.2 513 4.4e-49 PREDICTED: nucleoporin-like protein 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5RB98 180 7.4e-12 Nucleoporin-like protein 2 OS=Pongo abelii GN=NUPL2 PE=2 SV=1 PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.58633 BF_2 110.37 2.34 2258 780633762 XP_011686120.1 148 1.0e-06 PREDICTED: uncharacterized protein LOC105448935 isoform X1 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08468 Methyltransferase small domain N-terminal GO:0006364//GO:0006396//GO:0000154 rRNA processing//RNA processing//rRNA modification GO:0008990 rRNA (guanine-N2-)-methyltransferase activity -- -- -- -- Cluster-8309.58641 BF_2 4.00 0.54 597 73921480 AAZ94270.1 494 2.0e-47 cytochrome P450 [Leptinotarsa decemlineata]>gi|73921482|gb|AAZ94271.1| cytochrome P450 [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 P13527 398 1.1e-37 Cytochrome P450 6A1 OS=Musca domestica GN=CYP6A1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.58642 BF_2 9.71 0.87 752 642933131 XP_008197270.1 271 1.8e-21 PREDICTED: sesquipedalian-1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58644 BF_2 9.00 0.65 870 765166498 XP_011492063.1 340 2.1e-29 PREDICTED: gastrula zinc finger protein XlCGF28.1-like isoform X4 [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 326 3.7e-29 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF02892//PF04810//PF13912//PF01525//PF00096//PF13465 BED zinc finger//Sec23/Sec24 zinc finger//C2H2-type zinc finger//Rotavirus NS26//Zinc finger, C2H2 type//Zinc-finger double domain GO:0019079//GO:0006886//GO:0006888 viral genome replication//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0003677//GO:0008270//GO:0016887//GO:0046872//GO:0000287 DNA binding//zinc ion binding//ATPase activity//metal ion binding//magnesium ion binding GO:0030127//GO:0030430 COPII vesicle coat//host cell cytoplasm -- -- Cluster-8309.58655 BF_2 30.00 1.11 1415 642926052 XP_970129.2 706 1.3e-71 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 232 4.7e-18 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 PF06466//PF12464 PCAF (P300/CBP-associated factor) N-terminal domain//Maltose acetyltransferase GO:0006355//GO:0042967 regulation of transcription, DNA-templated//acyl-carrier-protein biosynthetic process GO:0016407//GO:0004402 acetyltransferase activity//histone acetyltransferase activity GO:0005634//GO:0000123 nucleus//histone acetyltransferase complex -- -- Cluster-8309.58656 BF_2 56.14 0.54 4627 642924185 XP_008194188.1 6346 0.0e+00 PREDICTED: chitin synthase 1 isoform X1 [Tribolium castaneum]>gi|33867317|gb|AAQ55059.1| chitin synthase CHS1A [Tribolium castaneum]>gi|34148367|gb|AAQ62693.1| chitin synthase variant 1 [Tribolium castaneum] 627401361 KF147149.1 1249 0 Anthonomus grandis chitin synthase I (CHS1) mRNA, complete cds K00698 CHS1 chitin synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00698 Q4P9K9 230 2.6e-17 Chitin synthase 8 OS=Ustilago maydis (strain 521 / FGSC 9021) GN=CHS8 PE=3 SV=1 PF04277//PF04689 Oxaloacetate decarboxylase, gamma chain//DNA binding protein S1FA GO:0006525//GO:0006560//GO:0006814//GO:0006355//GO:0006090//GO:0071436//GO:0006031 arginine metabolic process//proline metabolic process//sodium ion transport//regulation of transcription, DNA-templated//pyruvate metabolic process//sodium ion export//chitin biosynthetic process GO:0003677//GO:0004100//GO:0008948//GO:0015081 DNA binding//chitin synthase activity//oxaloacetate decarboxylase activity//sodium ion transmembrane transporter activity GO:0005634//GO:0016020 nucleus//membrane KOG2571 Chitin synthase/hyaluronan synthase (glycosyltransferases) Cluster-8309.58658 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58660 BF_2 40.66 0.75 2561 189235061 XP_001814285.1 1226 1.1e-131 PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915382|ref|XP_008190592.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|642915384|ref|XP_008190593.1| PREDICTED: oocyte zinc finger protein XlCOF6 [Tribolium castaneum]>gi|270003990|gb|EFA00438.1| hypothetical protein TcasGA2_TC003292 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P51523 313 3.5e-27 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.58677 BF_2 35.63 0.83 2093 270013573 EFA10021.1 936 4.0e-98 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58678 BF_2 172.90 2.37 3334 270013573 EFA10021.1 1066 5.3e-113 hypothetical protein TcasGA2_TC012193 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06384//PF00503//PF08558//PF01580//PF02367//PF00004//PF00735//PF08477//PF01926//PF00158//PF00493//PF04548//PF00910//PF03193//PF00005//PF00437//PF05049 Beta-catenin-interacting protein ICAT//G-protein alpha subunit//Telomere repeat binding factor (TRF)//FtsK/SpoIIIE family//Threonylcarbamoyl adenosine biosynthesis protein TsaE//ATPase family associated with various cellular activities (AAA)//Septin//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Sigma-54 interaction domain//MCM2/3/5 family//AIG1 family//RNA helicase//Protein of unknown function, DUF258//ABC transporter//Type II/IV secretion system protein//Interferon-inducible GTPase (IIGP) GO:0006260//GO:0007186//GO:0006355//GO:0007165//GO:0006810//GO:0002949//GO:0007264 DNA replication//G-protein coupled receptor signaling pathway//regulation of transcription, DNA-templated//signal transduction//transport//tRNA threonylcarbamoyladenosine modification//small GTPase mediated signal transduction GO:0016887//GO:0019001//GO:0008013//GO:0000166//GO:0031683//GO:0005524//GO:0008134//GO:0042162//GO:0003924//GO:0004871//GO:0042803//GO:0005525//GO:0003724//GO:0003677//GO:0003723 ATPase activity//guanyl nucleotide binding//beta-catenin binding//nucleotide binding//G-protein beta/gamma-subunit complex binding//ATP binding//transcription factor binding//telomeric DNA binding//GTPase activity//signal transducer activity//protein homodimerization activity//GTP binding//RNA helicase activity//DNA binding//RNA binding GO:0016342//GO:0016020//GO:0005667 catenin complex//membrane//transcription factor complex -- -- Cluster-8309.58686 BF_2 9.86 4.26 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03874//PF00484 RNA polymerase Rpb4//Carbonic anhydrase GO:0006144//GO:0006351//GO:0006807//GO:0006206//GO:0006730 purine nucleobase metabolic process//transcription, DNA-templated//nitrogen compound metabolic process//pyrimidine nucleobase metabolic process//one-carbon metabolic process GO:0004089//GO:0003899//GO:0008270 carbonate dehydratase activity//DNA-directed RNA polymerase activity//zinc ion binding GO:0005730 nucleolus -- -- Cluster-8309.58689 BF_2 18.00 0.45 1946 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58693 BF_2 92.93 0.78 5247 642929943 XP_008196036.1 677 1.1e-67 PREDICTED: microtubule-associated protein futsch-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q767L8 268 1.2e-21 Mediator of DNA damage checkpoint protein 1 OS=Sus scrofa GN=MDC1 PE=3 SV=1 PF01734//PF00498 Patatin-like phospholipase//FHA domain GO:0006629 lipid metabolic process GO:0005515 protein binding -- -- KOG2043 Signaling protein SWIFT and related BRCT domain proteins Cluster-8309.58700 BF_2 16.07 2.45 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58709 BF_2 140.00 2.36 2774 91077490 XP_968878.1 1686 5.7e-185 PREDICTED: protein downstream neighbor of son homolog [Tribolium castaneum]>gi|270002143|gb|EEZ98590.1| hypothetical protein TcasGA2_TC001105 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VNA8 789 2.4e-82 Protein downstream neighbor of son homolog OS=Drosophila melanogaster GN=hd PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4734 Uncharacterized conserved protein Cluster-8309.58711 BF_2 5.00 0.33 930 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58712 BF_2 34.15 1.93 1029 546679816 ERL90208.1 593 1.2e-58 hypothetical protein D910_07562 [Dendroctonus ponderosae] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 504 9.9e-50 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF13304//PF00664 ABC transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0016887//GO:0042626 ATP binding//ATPase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane -- -- Cluster-8309.58713 BF_2 5.00 1.03 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.58714 BF_2 7.00 0.94 600 478263210 ENN81600.1 397 3.6e-36 hypothetical protein YQE_02009, partial [Dendroctonus ponderosae] -- -- -- -- -- K01137 GNS N-acetylglucosamine-6-sulfatase http://www.genome.jp/dbget-bin/www_bget?ko:K01137 Q8BFR4 237 5.3e-19 N-acetylglucosamine-6-sulfatase OS=Mus musculus GN=Gns PE=2 SV=1 PF01663//PF00884 Type I phosphodiesterase / nucleotide pyrophosphatase//Sulfatase GO:0008152 metabolic process GO:0008484//GO:0003824 sulfuric ester hydrolase activity//catalytic activity -- -- KOG3731 Sulfatases Cluster-8309.58723 BF_2 10.83 0.60 1048 91093355 XP_969078.1 531 1.8e-51 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 159 1.0e-09 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF01165 Ribosomal protein S21 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.58727 BF_2 13.78 1.53 663 642916479 XP_008191061.1 390 2.6e-35 PREDICTED: serrate RNA effector molecule homolog isoform X2 [Tribolium castaneum]>gi|270004237|gb|EFA00685.1| hypothetical protein TcasGA2_TC003562 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q17FR9 195 4.3e-14 Serrate RNA effector molecule homolog OS=Aedes aegypti GN=Ars2 PE=3 SV=1 -- -- -- -- GO:0000166 nucleotide binding -- -- -- -- Cluster-8309.58731 BF_2 277.27 1.61 7503 642915658 XP_008190700.1 5670 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642915662|ref|XP_008190702.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9QZS7 1262 9.2e-137 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF13895//PF00041//PF05434 Immunoglobulin domain//Fibronectin type III domain//TMEM9 -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG3515 Predicted transmembrane protein of the immunoglobulin family of cell adhesion molecules Cluster-8309.58753 BF_2 4.00 0.42 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58763 BF_2 24.48 1.32 1063 642930146 XP_008196271.1 1024 1.3e-108 PREDICTED: hepatocyte nuclear factor 4-gamma isoform X5 [Tribolium castaneum] 189164165 EU545256.1 262 1.06848e-132 Callosobruchus maculatus putative hepatocyte nuclear factor 4 nuclear hormone receptor (HNF-4) mRNA, complete cds K07292 NR2A1, HNF4A hepatocyte nuclear factor 4-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07292 P49866 753 1.4e-78 Transcription factor HNF-4 homolog OS=Drosophila melanogaster GN=Hnf4 PE=1 SV=3 PF00105//PF00104 Zinc finger, C4 type (two domains)//Ligand-binding domain of nuclear hormone receptor GO:0006355//GO:0043401 regulation of transcription, DNA-templated//steroid hormone mediated signaling pathway GO:0008270//GO:0043565//GO:0003700 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG4215 Hepatocyte nuclear factor 4 and similar steroid hormone receptors Cluster-8309.58767 BF_2 497.07 4.10 5359 512921142 XP_004929807.1 2290 1.0e-254 PREDICTED: bestrophin-4 isoform X2 [Bombyx mori] 644995962 XM_001603356.3 234 2.02931e-116 PREDICTED: Nasonia vitripennis putative lysozyme-like protein (LOC100119673), transcript variant X1, mRNA -- -- -- -- Q6H1V1 898 1.1e-94 Bestrophin-3 OS=Mus musculus GN=Best3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3547 Bestrophin (Best vitelliform macular dystrophy-associated protein) Cluster-8309.58772 BF_2 45.69 0.51 4018 762120734 XP_011443287.1 442 1.5e-40 PREDICTED: collagen alpha-1(III) chain-like isoform X4 [Crassostrea gigas] 170039347 XM_001847447.1 45 1.76122e-11 Culex quinquefasciatus collagen alpha 1(XVIII) chain, mRNA K08135 COL15A collagen, type XV, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08135 P02453 359 2.5e-32 Collagen alpha-1(I) chain OS=Bos taurus GN=COL1A1 PE=1 SV=3 PF06482//PF10660 Collagenase NC10 and Endostatin//Iron-containing outer mitochondrial membrane protein N-terminus GO:0007155 cell adhesion GO:0051537//GO:0005198 2 iron, 2 sulfur cluster binding//structural molecule activity GO:0031012//GO:0043231 extracellular matrix//intracellular membrane-bounded organelle -- -- Cluster-8309.58779 BF_2 68.51 1.85 1840 260802183 XP_002595972.1 180 1.6e-10 hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae]>gi|229281225|gb|EEN51984.1| hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9PVG3 128 7.1e-06 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF13465//PF00096//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.58780 BF_2 63.49 1.66 1890 260802183 XP_002595972.1 180 1.6e-10 hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae]>gi|229281225|gb|EEN51984.1| hypothetical protein BRAFLDRAFT_60973 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q9PVG3 128 7.3e-06 RE1-silencing transcription factor B (Fragment) OS=Xenopus laevis GN=rest-b PE=2 SV=1 PF01363//PF07776//PF00096//PF13465 FYVE zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.58782 BF_2 22.89 0.37 2847 546684809 ERL94391.1 2055 9.5e-228 hypothetical protein D910_11670 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q92832 910 2.3e-96 Protein kinase C-binding protein NELL1 OS=Homo sapiens GN=NELL1 PE=1 SV=4 PF07645//PF00008//PF00093 Calcium-binding EGF domain//EGF-like domain//von Willebrand factor type C domain -- -- GO:0005515//GO:0005509 protein binding//calcium ion binding -- -- -- -- Cluster-8309.5879 BF_2 1.00 0.48 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58800 BF_2 2.00 1.22 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00374 Nickel-dependent hydrogenase -- -- GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.5881 BF_2 35.80 1.05 1720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58811 BF_2 86.00 1.83 2257 642917599 XP_008191274.1 335 2.1e-28 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VTC2 143 1.6e-07 Biogenesis of lysosome-related organelles complex 1 subunit 4 OS=Drosophila melanogaster GN=blos4 PE=1 SV=1 PF16519//PF01496//PF08651//PF02609//PF06009//PF05531//PF07464 Tetramerisation domain of TRPM//V-type ATPase 116kDa subunit family//DASH complex subunit Duo1//Exonuclease VII small subunit//Laminin Domain II//Nucleopolyhedrovirus P10 protein//Apolipophorin-III precursor (apoLp-III) GO:0006869//GO:0015991//GO:0006308//GO:0007155//GO:0051262//GO:0015992//GO:0007067 lipid transport//ATP hydrolysis coupled proton transport//DNA catabolic process//cell adhesion//protein tetramerization//proton transport//mitotic nuclear division GO:0008855//GO:0008289//GO:0015078 exodeoxyribonuclease VII activity//lipid binding//hydrogen ion transmembrane transporter activity GO:0072686//GO:0033179//GO:0005576//GO:0019028//GO:0009318//GO:0042729 mitotic spindle//proton-transporting V-type ATPase, V0 domain//extracellular region//viral capsid//exodeoxyribonuclease VII complex//DASH complex -- -- Cluster-8309.58812 BF_2 10.86 0.62 1017 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58813 BF_2 116.87 1.28 4104 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF07776 THAP domain//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.58814 BF_2 112.94 1.22 4152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07776//PF05485 Zinc-finger associated domain (zf-AD)//THAP domain -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.58815 BF_2 1.00 1.87 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58816 BF_2 1.00 0.32 419 642925330 XP_008194509.1 321 1.6e-27 PREDICTED: codanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K19531 CDAN1 codanin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K19531 Q8IWY9 231 1.8e-18 Codanin-1 OS=Homo sapiens GN=CDAN1 PE=1 SV=4 PF12920 TcdA/TcdB pore forming domain GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.58822 BF_2 2.00 0.44 476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58833 BF_2 18.04 0.57 1607 270014352 EFA10800.1 441 7.6e-41 odorant receptor 64 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V6H2 145 6.6e-08 Odorant receptor 49b OS=Drosophila melanogaster GN=Or49b PE=2 SV=1 PF02949 7tm Odorant receptor GO:0007187//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//sensory perception of smell GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.58835 BF_2 13.57 0.40 1713 270014352 EFA10800.1 441 8.1e-41 odorant receptor 64 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V6H2 145 7.0e-08 Odorant receptor 49b OS=Drosophila melanogaster GN=Or49b PE=2 SV=1 PF02949 7tm Odorant receptor GO:0007608//GO:0007187 sensory perception of smell//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0004984//GO:0005549 olfactory receptor activity//odorant binding GO:0016020 membrane -- -- Cluster-8309.58841 BF_2 4.00 0.35 763 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58849 BF_2 16.66 0.38 2135 642932631 XP_008196927.1 1581 6.5e-173 PREDICTED: runt-related transcription factor 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08775 186 1.5e-12 Runt-related transcription factor 2 OS=Mus musculus GN=Runx2 PE=1 SV=2 PF00853 Runt domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.58856 BF_2 42.14 0.43 4397 194035591 XP_001927046.1 416 1.7e-37 PREDICTED: zinc finger protein 572 isoform X1 [Sus scrofa]>gi|545820174|ref|XP_005662915.1| PREDICTED: zinc finger protein 572 isoform X2 [Sus scrofa] 642938625 XM_008203027.1 543 0 PREDICTED: Tribolium castaneum zinc finger protein rotund-like (LOC659822), transcript variant X4, mRNA -- -- -- -- Q32KN0 405 1.3e-37 Zinc finger protein 572 OS=Bos taurus GN=ZNF572 PE=2 SV=1 PF16622//PF13465//PF00096 zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.58858 BF_2 89.00 5.11 1016 546683448 ERL93254.1 356 3.5e-31 hypothetical protein D910_10550 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5886 BF_2 11.60 1.43 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58865 BF_2 36.50 1.24 1519 546677394 ERL88240.1 301 1.2e-24 hypothetical protein D910_05628, partial [Dendroctonus ponderosae] -- -- -- -- -- K19363 LITAF lipopolysaccharide-induced tumor necrosis factor-alpha factor http://www.genome.jp/dbget-bin/www_bget?ko:K19363 Q8QGW7 156 3.3e-09 Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog OS=Gallus gallus GN=LITAF PE=2 SV=1 PF03811 InsA N-terminal domain GO:0006313 transposition, DNA-mediated -- -- -- -- -- -- Cluster-8309.58866 BF_2 5.00 0.39 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58869 BF_2 39.24 1.34 1508 642936055 XP_008198283.1 814 4.0e-84 PREDICTED: fringe glycosyltransferase [Tribolium castaneum]>gi|270013211|gb|EFA09659.1| hypothetical protein TcasGA2_TC011785 [Tribolium castaneum] -- -- -- -- -- K05948 FNG fringe http://www.genome.jp/dbget-bin/www_bget?ko:K05948 Q24342 679 7.4e-70 Fringe glycosyltransferase OS=Drosophila melanogaster GN=fng PE=1 SV=1 PF02434 Fringe-like -- -- GO:0016757 transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.58870 BF_2 37.56 1.95 1091 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58879 BF_2 5.00 2.04 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58888 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58890 BF_2 302.11 6.56 2215 642918886 XP_008191628.1 1136 2.7e-121 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 358 1.8e-32 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF14372 Acyltransferase family//Domain of unknown function (DUF4413) -- -- GO:0003677//GO:0016747 DNA binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.58896 BF_2 3.00 1.26 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5890 BF_2 3.61 0.37 696 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00729 Viral coat protein (S domain) -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.58900 BF_2 3.00 0.31 697 270015628 EFA12076.1 282 9.0e-23 hypothetical protein TcasGA2_TC006883 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58902 BF_2 5.00 0.56 660 270015247 EFA11695.1 257 6.8e-20 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58904 BF_2 93.58 2.20 2068 91092792 XP_974059.1 1716 1.4e-188 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|642911515|ref|XP_008199454.1| PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|270014784|gb|EFA11232.1| hypothetical protein TcasGA2_TC010764 [Tribolium castaneum] 462386156 APGK01020335.1 242 2.76879e-121 Dendroctonus ponderosae Seq01020345, whole genome shotgun sequence K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1089 2.9e-117 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF02949 Divalent cation transporter//7tm Odorant receptor GO:0007187//GO:0006812//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//cation transport//sensory perception of smell GO:0008324//GO:0004984//GO:0005549 cation transmembrane transporter activity//olfactory receptor activity//odorant binding GO:0016020 membrane KOG3788 Predicted divalent cation transporter Cluster-8309.58905 BF_2 170.43 4.35 1926 91092792 XP_974059.1 1716 1.3e-188 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|642911515|ref|XP_008199454.1| PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum]>gi|270014784|gb|EFA11232.1| hypothetical protein TcasGA2_TC010764 [Tribolium castaneum] 462386156 APGK01020335.1 242 2.57539e-121 Dendroctonus ponderosae Seq01020345, whole genome shotgun sequence K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8IVJ1 1089 2.7e-117 Solute carrier family 41 member 1 OS=Homo sapiens GN=SLC41A1 PE=2 SV=2 PF01769//PF02949 Divalent cation transporter//7tm Odorant receptor GO:0007187//GO:0006812//GO:0007608 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//cation transport//sensory perception of smell GO:0008324//GO:0004984//GO:0005549 cation transmembrane transporter activity//olfactory receptor activity//odorant binding GO:0016020 membrane KOG3788 Predicted divalent cation transporter Cluster-8309.58916 BF_2 28.47 0.36 3593 641663663 XP_008182723.1 1405 2.8e-152 PREDICTED: uncharacterized protein LOC103309327 [Acyrthosiphon pisum]>gi|641679805|ref|XP_008188719.1| PREDICTED: uncharacterized protein LOC103310986 [Acyrthosiphon pisum] 641663662 XM_008184501.1 538 0 PREDICTED: Acyrthosiphon pisum uncharacterized LOC103309327 (LOC103309327), mRNA >gnl|BL_ORD_ID|19443021 PREDICTED: Acyrthosiphon pisum uncharacterized LOC103310986 (LOC103310986), mRNA -- -- -- -- -- -- -- -- PF04827//PF02944 Plant transposon protein//BESS motif -- -- GO:0016788//GO:0003677 hydrolase activity, acting on ester bonds//DNA binding -- -- -- -- Cluster-8309.58919 BF_2 13.00 2.01 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05371 Phage major coat protein, Gp8 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.58922 BF_2 43.00 0.60 3262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58924 BF_2 40.00 0.59 3139 546685576 ERL95063.1 2573 9.0e-288 hypothetical protein D910_12333 [Dendroctonus ponderosae] 564241862 XM_006277680.1 37 3.84299e-07 PREDICTED: Alligator mississippiensis REV1, polymerase (DNA directed) (REV1), transcript variant X3, mRNA K03515 REV1 DNA repair protein REV1 http://www.genome.jp/dbget-bin/www_bget?ko:K03515 Q4KWZ7 1026 9.0e-110 DNA repair protein REV1 OS=Gallus gallus GN=REV1 PE=2 SV=1 PF11799//PF00961//PF00817//PF03206 impB/mucB/samB family C-terminal domain//LAGLIDADG endonuclease//impB/mucB/samB family//Nitrogen fixation protein NifW GO:0009399//GO:0006281 nitrogen fixation//DNA repair GO:0004519//GO:0003684 endonuclease activity//damaged DNA binding -- -- KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase Cluster-8309.58930 BF_2 137.35 2.32 2766 91078378 XP_974191.1 3075 0.0e+00 PREDICTED: probable leucine--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270003885|gb|EFA00333.1| hypothetical protein TcasGA2_TC003172 [Tribolium castaneum] -- -- -- -- -- K01869 LARS, leuS leucyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01869 Q5RDP4 1763 2.7e-195 Probable leucine--tRNA ligase, mitochondrial OS=Pongo abelii GN=LARS2 PE=2 SV=1 PF08264//PF03119//PF09334//PF00133//PF13603 Anticodon-binding domain of tRNA//NAD-dependent DNA ligase C4 zinc finger domain//tRNA synthetases class I (M)//tRNA synthetases class I (I, L, M and V)//Leucyl-tRNA synthetase, Domain 2 GO:0006429//GO:0006260//GO:0006418//GO:0006450//GO:0009099//GO:0009098//GO:0009097//GO:0006281 leucyl-tRNA aminoacylation//DNA replication//tRNA aminoacylation for protein translation//regulation of translational fidelity//valine biosynthetic process//leucine biosynthetic process//isoleucine biosynthetic process//DNA repair GO:0000166//GO:0004812//GO:0002161//GO:0003911//GO:0005524//GO:0004823 nucleotide binding//aminoacyl-tRNA ligase activity//aminoacyl-tRNA editing activity//DNA ligase (NAD+) activity//ATP binding//leucine-tRNA ligase activity GO:0005737 cytoplasm KOG0435 Leucyl-tRNA synthetase Cluster-8309.58932 BF_2 76.63 1.63 2248 642924842 XP_008194063.1 618 3.2e-61 PREDICTED: regucalcin [Tribolium castaneum]>gi|642924844|ref|XP_008194064.1| PREDICTED: regucalcin [Tribolium castaneum]>gi|270006688|gb|EFA03136.1| hypothetical protein TcasGA2_TC013048 [Tribolium castaneum] -- -- -- -- -- K01053 E3.1.1.17, gnl, RGN gluconolactonase http://www.genome.jp/dbget-bin/www_bget?ko:K01053 Q6TLF6 375 2.0e-34 Regucalcin OS=Danio rerio GN=rgn PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58933 BF_2 57.72 0.70 3726 289474532 ADC97877.1 4227 0.0e+00 ATP-binding cassette transporter [Chrysomela tremula] 829982474 XM_012726010.1 38 1.27063e-07 PREDICTED: Condylura cristata ATP-binding cassette, sub-family B (MDR/TAP), member 11 (ABCB11), transcript variant X2, mRNA K05658 ABCB1 ATP-binding cassette, subfamily B (MDR/TAP), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05658 P21448 2612 1.3e-293 Multidrug resistance protein 1 OS=Cricetulus griseus GN=ABCB1 PE=1 SV=2 PF07728//PF01583//PF13304//PF00664//PF00430//PF00004//PF03193//PF00005//PF06414//PF00006//PF01637//PF00485//PF00503//PF00931//PF00910 AAA domain (dynein-related subfamily)//Adenylylsulphate kinase//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter transmembrane region//ATP synthase B/B' CF(0)//ATPase family associated with various cellular activities (AAA)//Protein of unknown function, DUF258//ABC transporter//Zeta toxin//ATP synthase alpha/beta family, nucleotide-binding domain//Archaeal ATPase//Phosphoribulokinase / Uridine kinase family//G-protein alpha subunit//NB-ARC domain//RNA helicase GO:0008152//GO:0000103//GO:0006144//GO:0015986//GO:0055085//GO:0007165//GO:0006810//GO:0007186//GO:0015992 metabolic process//sulfate assimilation//purine nucleobase metabolic process//ATP synthesis coupled proton transport//transmembrane transport//signal transduction//transport//G-protein coupled receptor signaling pathway//proton transport GO:0003723//GO:0004020//GO:0043531//GO:0004871//GO:0005525//GO:0003724//GO:0031683//GO:0005524//GO:0003924//GO:0019001//GO:0015078//GO:0016887//GO:0016301//GO:0042626 RNA binding//adenylylsulfate kinase activity//ADP binding//signal transducer activity//GTP binding//RNA helicase activity//G-protein beta/gamma-subunit complex binding//ATP binding//GTPase activity//guanyl nucleotide binding//hydrogen ion transmembrane transporter activity//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0045263 integral component of membrane//proton-transporting ATP synthase complex, coupling factor F(o) -- -- Cluster-8309.58938 BF_2 7.00 0.45 937 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16588//PF00098 C2H2 zinc-finger//Zinc knuckle -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- -- -- Cluster-8309.58941 BF_2 100.74 0.98 4593 642914198 XP_008201586.1 3974 0.0e+00 PREDICTED: uncharacterized protein LOC661711 isoform X2 [Tribolium castaneum] 642914197 XM_008203364.1 679 0 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- P59808 378 1.8e-34 SAM and SH3 domain-containing protein 1 OS=Mus musculus GN=Sash1 PE=1 SV=1 PF15360//PF00018//PF04904//PF07647//PF00536 APJ endogenous ligand//SH3 domain//NAB conserved region 1 (NCD1)//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) GO:0045892//GO:0007165 negative regulation of transcription, DNA-templated//signal transduction GO:0031704//GO:0005515//GO:0005179 apelin receptor binding//protein binding//hormone activity GO:0005634 nucleus -- -- Cluster-8309.58942 BF_2 39.68 0.56 3252 189235122 XP_001811652.1 2823 0.0e+00 PREDICTED: histone-lysine N-methyltransferase E(z) [Tribolium castaneum]>gi|270003813|gb|EFA00261.1| hypothetical protein TcasGA2_TC003094 [Tribolium castaneum] 642915637 XM_001811600.2 412 0 PREDICTED: Tribolium castaneum histone-lysine N-methyltransferase E(z) (LOC659759), mRNA K11430 EZH2 histone-lysine N-methyltransferase EZH2 http://www.genome.jp/dbget-bin/www_bget?ko:K11430 P42124 1522 2.8e-167 Histone-lysine N-methyltransferase E(z) OS=Drosophila melanogaster GN=E(z) PE=1 SV=2 PF00856//PF01496//PF05602//PF05132 SET domain//V-type ATPase 116kDa subunit family//Cleft lip and palate transmembrane protein 1 (CLPTM1)//RNA polymerase III RPC4 GO:0015992//GO:0006206//GO:0015991//GO:0006144//GO:0006383//GO:0006351 proton transport//pyrimidine nucleobase metabolic process//ATP hydrolysis coupled proton transport//purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated GO:0003682//GO:0015078//GO:0003899//GO:0005515//GO:0003677 chromatin binding//hydrogen ion transmembrane transporter activity//DNA-directed RNA polymerase activity//protein binding//DNA binding GO:0005730//GO:0005666//GO:0016021//GO:0033179//GO:0000785 nucleolus//DNA-directed RNA polymerase III complex//integral component of membrane//proton-transporting V-type ATPase, V0 domain//chromatin KOG1079 Transcriptional repressor EZH1 Cluster-8309.58945 BF_2 105.98 2.26 2250 817059940 XP_012251499.1 2538 7.4e-284 PREDICTED: sodium-dependent noradrenaline transporter [Athalia rosae] 170049841 XM_001870902.1 357 0 Culex quinquefasciatus norepinephrine/norepinephrine transporter, mRNA K05036 SLC6A3 solute carrier family 6 (neurotransmitter transporter, dopamine) member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05036 P51143 1799 1.5e-199 Sodium-dependent noradrenaline transporter OS=Bos taurus GN=SLC6A2 PE=2 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006812//GO:0006836 cation transport//neurotransmitter transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane KOG3659 Sodium-neurotransmitter symporter Cluster-8309.58948 BF_2 25.00 1.07 1264 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58949 BF_2 235.69 2.21 4744 641658099 XP_008180596.1 1075 6.8e-114 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5R5U3 967 9.4e-103 Zinc finger protein 271 OS=Pongo abelii GN=ZNF271 PE=2 SV=1 PF13912//PF00400//PF16622//PF07776//PF13465//PF00096 C2H2-type zinc finger//WD domain, G-beta repeat//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.58965 BF_2 84.58 1.99 2069 91084525 XP_972529.1 881 9.3e-92 PREDICTED: serine/threonine-protein kinase Chk2 isoform X1 [Tribolium castaneum]>gi|270012661|gb|EFA09109.1| hypothetical protein TcasGA2_TC015484 [Tribolium castaneum] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 Q9Z265 734 4.3e-76 Serine/threonine-protein kinase Chk2 OS=Mus musculus GN=Chek2 PE=1 SV=1 PF06293//PF00498//PF00069//PF07714 Lipopolysaccharide kinase (Kdo/WaaP) family//FHA domain//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0016773//GO:0005524//GO:0005515//GO:0004672 phosphotransferase activity, alcohol group as acceptor//ATP binding//protein binding//protein kinase activity GO:0016020 membrane KOG0615 Serine/threonine protein kinase Chk2 and related proteins Cluster-8309.58967 BF_2 80.42 1.48 2562 91084525 XP_972529.1 947 2.6e-99 PREDICTED: serine/threonine-protein kinase Chk2 isoform X1 [Tribolium castaneum]>gi|270012661|gb|EFA09109.1| hypothetical protein TcasGA2_TC015484 [Tribolium castaneum] -- -- -- -- -- K06641 CHK2 serine/threonine-protein kinase Chk2 http://www.genome.jp/dbget-bin/www_bget?ko:K06641 O61267 762 3.0e-79 Ovarian-specific serine/threonine-protein kinase Lok OS=Drosophila melanogaster GN=lok PE=2 SV=1 PF07714//PF06293//PF00498//PF00069//PF05445 Protein tyrosine kinase//Lipopolysaccharide kinase (Kdo/WaaP) family//FHA domain//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0016773//GO:0005515//GO:0004672 ATP binding//phosphotransferase activity, alcohol group as acceptor//protein binding//protein kinase activity GO:0016020 membrane KOG0615 Serine/threonine protein kinase Chk2 and related proteins Cluster-8309.58974 BF_2 43.04 0.84 2440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58978 BF_2 42.79 0.57 3435 546670638 ERL83322.1 588 1.5e-57 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C6L5 203 2.7e-14 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.58980 BF_2 2.00 1.16 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58981 BF_2 31.00 1.55 1125 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.58983 BF_2 78.79 2.68 1516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01331 mRNA capping enzyme, catalytic domain GO:0006397//GO:0006370 mRNA processing//7-methylguanosine mRNA capping GO:0004484 mRNA guanylyltransferase activity -- -- -- -- Cluster-8309.58986 BF_2 12.92 0.93 866 282721120 NP_001164234.1 559 8.5e-55 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V6D6 388 2.4e-36 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0020037//GO:0004497//GO:0005506//GO:0016705//GO:0009055 heme binding//monooxygenase activity//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//electron carrier activity -- -- -- -- Cluster-8309.58987 BF_2 16.76 0.50 1691 282721120 NP_001164234.1 1404 1.7e-152 cytochrome P450 301B1 [Tribolium castaneum]>gi|270006359|gb|EFA02807.1| cytochrome P450 301B1 [Tribolium castaneum] -- -- -- -- -- K17960 CYP49A cytochrome P450, family 49, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K17960 Q9V5L3 978 1.8e-104 Probable cytochrome P450 49a1 OS=Drosophila melanogaster GN=Cyp49a1 PE=2 SV=3 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0005506//GO:0020037//GO:0004497 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding//monooxygenase activity -- -- -- -- Cluster-8309.590 BF_2 3.00 0.42 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59003 BF_2 8.00 1.15 577 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59014 BF_2 39.82 3.24 801 642914271 XP_008201616.1 451 2.6e-42 PREDICTED: sulfiredoxin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12260 SRX1 sulfiredoxin http://www.genome.jp/dbget-bin/www_bget?ko:K12260 Q9D975 333 5.2e-30 Sulfiredoxin-1 OS=Mus musculus GN=Srxn1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3388 Predicted transcription regulator/nuclease, contains ParB domain Cluster-8309.59017 BF_2 2.00 1.34 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59021 BF_2 15.70 0.32 2362 189237223 XP_969624.2 1395 2.7e-151 PREDICTED: 45 kDa calcium-binding protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JA6 293 6.7e-25 45 kDa calcium-binding protein OS=Xenopus laevis GN=sdf4 PE=2 SV=1 PF13202//PF00036//PF13833//PF13405//PF13499 EF hand//EF hand//EF-hand domain pair//EF-hand domain//EF-hand domain pair -- -- GO:0005509 calcium ion binding -- -- KOG4251 Calcium binding protein Cluster-8309.59025 BF_2 22.34 1.18 1079 861594808 KMQ83108.1 691 5.2e-70 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59026 BF_2 11.01 0.42 1373 91084843 XP_966905.1 821 5.6e-85 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 357 1.5e-32 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.59027 BF_2 32.00 1.57 1142 91084843 XP_966905.1 674 5.2e-68 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q922J9 457 3.1e-44 Fatty acyl-CoA reductase 1 OS=Mus musculus GN=Far1 PE=1 SV=1 PF01370//PF01073//PF01118 NAD dependent epimerase/dehydratase family//3-beta hydroxysteroid dehydrogenase/isomerase family//Semialdehyde dehydrogenase, NAD binding domain GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process GO:0080019//GO:0000166//GO:0016620//GO:0003824//GO:0050662//GO:0003854//GO:0016616//GO:0051287 fatty-acyl-CoA reductase (alcohol-forming) activity//nucleotide binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.59029 BF_2 34.90 1.73 1133 91084843 XP_966905.1 1042 1.1e-110 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 509 2.9e-50 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015 Male sterility protein -- -- GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity -- -- -- -- Cluster-8309.59030 BF_2 8.09 0.37 1194 91084843 XP_966905.1 821 4.9e-85 PREDICTED: putative fatty acyl-CoA reductase CG5065 [Tribolium castaneum]>gi|270008576|gb|EFA05024.1| hypothetical protein TcasGA2_TC015111 [Tribolium castaneum] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 357 1.3e-32 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF10371//PF03015 Domain of unknown function//Male sterility protein GO:0055114 oxidation-reduction process GO:0080019//GO:0016903 fatty-acyl-CoA reductase (alcohol-forming) activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors -- -- -- -- Cluster-8309.59031 BF_2 112.00 1.03 4815 478259731 ENN79575.1 3841 0.0e+00 hypothetical protein YQE_04037, partial [Dendroctonus ponderosae] 688768668 LL362340.1 36 2.12874e-06 Cylicostephanus goldi genome assembly C_goldi_Cheshire ,scaffold CGOC_contig0000203 K02320 POLA1 DNA polymerase alpha subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K02320 Q9DE46 2639 1.3e-296 DNA polymerase alpha catalytic subunit OS=Xenopus laevis GN=pola1 PE=1 SV=1 PF01119//PF08996//PF00136//PF03104 DNA mismatch repair protein, C-terminal domain//DNA Polymerase alpha zinc finger//DNA polymerase family B//DNA polymerase family B, exonuclease domain GO:0006260//GO:0006298 DNA replication//mismatch repair GO:0001882//GO:0030983//GO:0008408//GO:0000166//GO:0003887//GO:0003677//GO:0005524 nucleoside binding//mismatched DNA binding//3'-5' exonuclease activity//nucleotide binding//DNA-directed DNA polymerase activity//DNA binding//ATP binding GO:0042575 DNA polymerase complex KOG0970 DNA polymerase alpha, catalytic subunit Cluster-8309.59032 BF_2 15.01 0.95 947 984255 CAA61238.1 337 5.1e-29 cuticular protein [Tenebrio molitor]>gi|1587208|prf||2206329A cuticular protein -- -- -- -- -- -- -- -- -- P80686 337 2.1e-30 Larval/pupal cuticle protein H1C OS=Tenebrio molitor GN=LPCP-22 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59033 BF_2 2.00 1.12 358 3121955 Q94804.2 187 4.8e-12 RecName: Full=Cuticle protein LPCP-23; AltName: Full=TMLPCP-23; Flags: Precursor [Tenebrio molitor]>gi|2281990|emb|CAA70341.1| cuticular protein [Tenebrio molitor] -- -- -- -- -- -- -- -- -- P80685 187 2.0e-13 Pupal cuticle protein G1A OS=Tenebrio molitor PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59034 BF_2 14.99 0.50 1535 984255 CAA61238.1 337 8.3e-29 cuticular protein [Tenebrio molitor]>gi|1587208|prf||2206329A cuticular protein -- -- -- -- -- -- -- -- -- P80686 337 3.4e-30 Larval/pupal cuticle protein H1C OS=Tenebrio molitor GN=LPCP-22 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59041 BF_2 3.00 0.49 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5905 BF_2 5.00 0.96 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59054 BF_2 9.77 0.71 861 478251232 ENN71706.1 374 2.4e-33 hypothetical protein YQE_11629, partial [Dendroctonus ponderosae]>gi|546676148|gb|ERL87215.1| hypothetical protein D910_04614 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59059 BF_2 21.70 1.04 1158 642936055 XP_008198283.1 818 1.1e-84 PREDICTED: fringe glycosyltransferase [Tribolium castaneum]>gi|270013211|gb|EFA09659.1| hypothetical protein TcasGA2_TC011785 [Tribolium castaneum] 462318872 APGK01044259.1 47 3.84554e-13 Dendroctonus ponderosae Seq01044269, whole genome shotgun sequence K05948 FNG fringe http://www.genome.jp/dbget-bin/www_bget?ko:K05948 Q24342 574 8.5e-58 Fringe glycosyltransferase OS=Drosophila melanogaster GN=fng PE=1 SV=1 PF02434//PF01762 Fringe-like//Galactosyltransferase GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.59062 BF_2 5.00 2.42 371 -- -- -- -- -- 470482009 NR_076508.1 337 7.13071e-175 Sphingomonas wittichii strain RW1 23S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59067 BF_2 0.61 0.53 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59068 BF_2 4.00 0.62 556 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59075 BF_2 111.00 2.68 2019 213623544 AAI69887.1 700 8.9e-71 Frizzled 10A [Xenopus laevis]>gi|213625125|gb|AAI69883.1| Frizzled 10A [Xenopus laevis] -- -- -- -- -- -- -- -- -- Q9DEB5 700 3.6e-72 Frizzled-10-A OS=Xenopus laevis GN=fzd10-a PE=2 SV=1 PF01534//PF01392 Frizzled/Smoothened family membrane region//Fz domain GO:0007166 cell surface receptor signaling pathway GO:0005515 protein binding GO:0016020 membrane -- -- Cluster-8309.59078 BF_2 1.00 2.27 280 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59085 BF_2 35.71 1.06 1700 558186421 XP_006102446.1 472 2.0e-44 PREDICTED: zinc finger protein 850-like, partial [Myotis lucifugus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51814 449 3.9e-43 Zinc finger protein 41 OS=Homo sapiens GN=ZNF41 PE=1 SV=2 PF16622//PF00412//PF04810//PF13912//PF07975//PF13465//PF00628//PF00096 zinc-finger C2H2-type//LIM domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//TFIIH C1-like domain//Zinc-finger double domain//PHD-finger//Zinc finger, C2H2 type GO:0006281//GO:0006886//GO:0006888 DNA repair//intracellular protein transport//ER to Golgi vesicle-mediated transport GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.59086 BF_2 20.63 2.77 599 642937753 XP_008198932.1 221 9.2e-16 PREDICTED: zinc finger protein 480-like [Tribolium castaneum]>gi|270000769|gb|EEZ97216.1| hypothetical protein TcasGA2_TC011009 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00628//PF13912//PF07776//PF00096//PF13465 PHD-finger//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0008270//GO:0046872//GO:0005515 zinc ion binding//metal ion binding//protein binding GO:0005634 nucleus -- -- Cluster-8309.59088 BF_2 29.83 0.48 2873 675378821 KFM71723.1 674 1.3e-67 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q5RDX1 645 1.2e-65 Zinc finger protein 585A OS=Pongo abelii GN=ZNF585A PE=2 SV=1 PF13465//PF00096//PF07975//PF00412//PF04810//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//TFIIH C1-like domain//LIM domain//Sec23/Sec24 zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type GO:0006886//GO:0006281//GO:0006888 intracellular protein transport//DNA repair//ER to Golgi vesicle-mediated transport GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0030127 COPII vesicle coat -- -- Cluster-8309.59092 BF_2 55.83 1.25 2162 645016819 XP_008211643.1 572 6.6e-56 PREDICTED: angiogenic factor with G patch and FHA domains 1 isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- Q8N302 132 2.9e-06 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF07851//PF00498 TMPIT-like protein//FHA domain -- -- GO:0005515 protein binding GO:0016021 integral component of membrane KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.59103 BF_2 65.00 2.87 1235 391226631 AFM38203.1 701 4.2e-71 Rieske Fe-S protein 1 [Anasa tristis] -- -- -- -- -- K00411 UQCRFS1, RIP1, petA ubiquinol-cytochrome c reductase iron-sulfur subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00411 Q69BJ7 657 2.2e-67 Cytochrome b-c1 complex subunit Rieske, mitochondrial OS=Saimiri sciureus GN=UQCRFS1 PE=3 SV=1 PF03332//PF02921//PF00355 Eukaryotic phosphomannomutase//Ubiquinol cytochrome reductase transmembrane region//Rieske [2Fe-2S] domain GO:0009298//GO:0006119//GO:0006118//GO:0015992//GO:0006013//GO:0055114//GO:0006000 GDP-mannose biosynthetic process//oxidative phosphorylation//obsolete electron transport//proton transport//mannose metabolic process//oxidation-reduction process//fructose metabolic process GO:0051537//GO:0004615//GO:0008121//GO:0016491 2 iron, 2 sulfur cluster binding//phosphomannomutase activity//ubiquinol-cytochrome-c reductase activity//oxidoreductase activity GO:0005737 cytoplasm KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-8309.59105 BF_2 12.00 0.47 1351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59107 BF_2 55.00 0.57 4350 642912824 XP_008201267.1 789 9.2e-81 PREDICTED: RNA polymerase II degradation factor 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59108 BF_2 122.04 1.64 3402 270011110 EFA07558.1 487 7.5e-46 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 351 1.8e-31 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59109 BF_2 110.78 3.50 1613 270011110 EFA07558.1 571 6.4e-56 serine protease P136 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 433 2.7e-41 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59118 BF_2 56.40 1.48 1886 546683519 ERL93321.1 209 7.1e-14 hypothetical protein D910_10615 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus -- -- Cluster-8309.59119 BF_2 17.37 0.76 1242 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59131 BF_2 404.54 6.33 2962 91093748 XP_969297.1 2060 2.6e-228 PREDICTED: cerebellar degeneration-related protein 2-like isoform X1 [Tribolium castaneum]>gi|270013015|gb|EFA09463.1| hypothetical protein TcasGA2_TC010679 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 334 1.5e-29 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF04977 Septum formation initiator GO:0007049 cell cycle -- -- -- -- -- -- Cluster-8309.59134 BF_2 17.00 0.40 2084 478257549 ENN77703.1 192 7.4e-12 hypothetical protein YQE_05775, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.59139 BF_2 77.64 0.68 5044 780175874 XP_011661330.1 388 3.3e-34 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B-like [Strongylocentrotus purpuratus] -- -- -- -- -- K10380 ANK ankyrin http://www.genome.jp/dbget-bin/www_bget?ko:K10380 Q12955 299 2.9e-25 Ankyrin-3 OS=Homo sapiens GN=ANK3 PE=1 SV=3 PF04851//PF12515//PF13606//PF00023//PF11421//PF00004 Type III restriction enzyme, res subunit//Ca2+-ATPase N terminal autoinhibitory domain//Ankyrin repeat//Ankyrin repeat//ATP synthase F1 beta subunit//ATPase family associated with various cellular activities (AAA) GO:0006754 ATP biosynthetic process GO:0016887//GO:0005524//GO:0005516//GO:0016787//GO:0003677//GO:0005515 ATPase activity//ATP binding//calmodulin binding//hydrolase activity//DNA binding//protein binding GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-8309.59140 BF_2 344.51 2.72 5593 642917556 XP_008191255.1 3201 0.0e+00 PREDICTED: uncharacterized protein LOC659080 [Tribolium castaneum]>gi|270004431|gb|EFA00879.1| hypothetical protein TcasGA2_TC003783 [Tribolium castaneum] 642917555 XM_008193033.1 74 1.86012e-27 PREDICTED: Tribolium castaneum uncharacterized LOC659080 (LOC659080), mRNA -- -- -- -- Q9TW28 257 2.4e-20 Myosin-M heavy chain OS=Dictyostelium discoideum GN=myoM PE=1 SV=1 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- -- -- Cluster-8309.59145 BF_2 2.00 2.86 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59150 BF_2 1.00 1.91 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59154 BF_2 7.00 0.84 636 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59165 BF_2 5.04 0.31 962 478252119 ENN72550.1 505 1.7e-48 hypothetical protein YQE_10890, partial [Dendroctonus ponderosae]>gi|546676991|gb|ERL87915.1| hypothetical protein D910_05303 [Dendroctonus ponderosae] -- -- -- -- -- K12183 TSG101, STP22, VPS23 ESCRT-I complex subunit TSG101 http://www.genome.jp/dbget-bin/www_bget?ko:K12183 Q61187 367 7.1e-34 Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2 PF05743//PF02911 UEV domain//Formyl transferase, C-terminal domain GO:0006464//GO:0015031//GO:0009058 cellular protein modification process//protein transport//biosynthetic process GO:0016742 hydroxymethyl-, formyl- and related transferase activity -- -- KOG2391 Vacuolar sorting protein/ubiquitin receptor VPS23 Cluster-8309.59167 BF_2 6.00 1.41 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59173 BF_2 97.13 0.99 4408 270009035 EFA05483.1 2466 3.2e-275 hypothetical protein TcasGA2_TC015667 [Tribolium castaneum] 642926285 XM_008196640.1 273 3.4825e-138 PREDICTED: Tribolium castaneum tyrosine-protein kinase transmembrane receptor Ror-like (LOC663368), mRNA K05122 ROR1, NTRKR1 receptor tyrosine kinase-like orphan receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05122 Q24488 1584 2.5e-174 Tyrosine-protein kinase transmembrane receptor Ror OS=Drosophila melanogaster GN=Ror PE=1 SV=1 PF13895//PF00069//PF01392//PF07714 Immunoglobulin domain//Protein kinase domain//Fz domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0005515//GO:0004672//GO:0005524 protein binding//protein kinase activity//ATP binding -- -- KOG1026 Nerve growth factor receptor TRKA and related tyrosine kinases Cluster-8309.59178 BF_2 45.67 0.65 3240 642926332 XP_968832.2 2767 3.0e-310 PREDICTED: RING finger protein 207 isoform X2 [Tribolium castaneum] 642926333 XM_008196659.1 246 2.60688e-123 PREDICTED: Tribolium castaneum RING finger protein 207 (LOC657271), transcript variant X3, mRNA -- -- -- -- Q6ZRF8 580 4.8e-58 RING finger protein 207 OS=Homo sapiens GN=RNF207 PE=2 SV=2 PF04728//PF04513//PF06005//PF01667//PF04673 Lipoprotein leucine-zipper//Baculovirus polyhedron envelope protein, PEP, C terminus//Protein of unknown function (DUF904)//Ribosomal protein S27//Polyketide synthesis cyclase GO:0000917//GO:0043093//GO:0042254//GO:0006412//GO:0030639 barrier septum assembly//FtsZ-dependent cytokinesis//ribosome biogenesis//translation//polyketide biosynthetic process GO:0003735//GO:0005198 structural constituent of ribosome//structural molecule activity GO:0005737//GO:0005622//GO:0005840//GO:0019031//GO:0019867//GO:0019028 cytoplasm//intracellular//ribosome//viral envelope//outer membrane//viral capsid -- -- Cluster-8309.59180 BF_2 133.61 1.96 3138 642931541 XP_008196629.1 2805 0.0e+00 PREDICTED: serine/threonine-protein kinase/endoribonuclease IRE1 [Tribolium castaneum]>gi|270012165|gb|EFA08613.1| hypothetical protein TcasGA2_TC006276 [Tribolium castaneum] -- -- -- -- -- K08852 ERN1 serine/threonine-protein kinase/endoribonuclease IRE1 http://www.genome.jp/dbget-bin/www_bget?ko:K08852 Q76MJ5 1249 1.2e-135 Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Homo sapiens GN=ERN2 PE=1 SV=4 PF00069//PF06293//PF07714//PF06479//PF00804 Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein tyrosine kinase//Ribonuclease 2-5A//Syntaxin GO:0044238//GO:0051252//GO:0006468//GO:0006397//GO:0044260 primary metabolic process//regulation of RNA metabolic process//protein phosphorylation//mRNA processing//cellular macromolecule metabolic process GO:0004672//GO:0016773//GO:0004540//GO:0005524 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ribonuclease activity//ATP binding GO:0016020 membrane KOG1027 Serine/threonine protein kinase and endoribonuclease ERN1/IRE1, sensor of the unfolded protein response pathway Cluster-8309.59182 BF_2 207.22 2.55 3691 478256893 ENN77062.1 359 5.6e-31 hypothetical protein YQE_06397, partial [Dendroctonus ponderosae]>gi|546682164|gb|ERL92140.1| hypothetical protein D910_09460 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NDX5 209 5.7e-15 Putative zinc finger protein 840 OS=Homo sapiens GN=ZNF840P PE=5 SV=5 PF01844//PF16622//PF02150//PF07975//PF00096//PF13465 HNH endonuclease//zinc-finger C2H2-type//RNA polymerases M/15 Kd subunit//TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006206//GO:0006281//GO:0006144//GO:0006351 pyrimidine nucleobase metabolic process//DNA repair//purine nucleobase metabolic process//transcription, DNA-templated GO:0046872//GO:0003676//GO:0008270//GO:0003677//GO:0003899//GO:0004519 metal ion binding//nucleic acid binding//zinc ion binding//DNA binding//DNA-directed RNA polymerase activity//endonuclease activity GO:0005730 nucleolus -- -- Cluster-8309.59186 BF_2 7.49 0.78 689 642927136 XP_972282.2 565 1.4e-55 PREDICTED: spermine oxidase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6YYZ1 158 8.8e-10 Lysine-specific histone demethylase 1 homolog 2 OS=Oryza sativa subsp. japonica GN=Os08g0143400 PE=2 SV=1 PF01593 Flavin containing amine oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG0685 Flavin-containing amine oxidase Cluster-8309.59190 BF_2 4.48 0.82 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59191 BF_2 13.52 1.96 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59198 BF_2 8.00 0.49 977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- -- -- Cluster-8309.592 BF_2 3.00 0.34 661 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59202 BF_2 13.50 0.72 1071 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02468 Photosystem II reaction centre N protein (psbN) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523//GO:0009539 membrane//photosystem II//photosystem II reaction center -- -- Cluster-8309.59204 BF_2 161.92 3.34 2318 642938915 XP_008195579.1 1677 5.2e-184 PREDICTED: suppressor APC domain-containing protein 2 [Tribolium castaneum]>gi|270016161|gb|EFA12609.1| hypothetical protein TcasGA2_TC006850 [Tribolium castaneum] 642938914 XM_008197357.1 121 5.70411e-54 PREDICTED: Tribolium castaneum suppressor APC domain-containing protein 2 (LOC660078), mRNA -- -- -- -- Q9D818 258 7.5e-21 Suppressor APC domain-containing protein 2 OS=Mus musculus GN=Sapcd2 PE=2 SV=1 PF13405//PF04111 EF-hand domain//Autophagy protein Apg6 GO:0006914 autophagy GO:0005509 calcium ion binding -- -- -- -- Cluster-8309.59205 BF_2 9.07 0.41 1204 642933039 XP_008197239.1 704 1.8e-71 PREDICTED: neo-calmodulin-like isoform X1 [Tribolium castaneum] 642933040 XM_008199018.1 219 9.71843e-109 PREDICTED: Tribolium castaneum neo-calmodulin-like (LOC659938), transcript variant X2, mRNA K02183 CALM calmodulin http://www.genome.jp/dbget-bin/www_bget?ko:K02183 Q8STF0 345 3.2e-31 Calmodulin OS=Strongylocentrotus intermedius PE=2 SV=3 PF13499//PF10591//PF13405//PF13833//PF00036//PF12763//PF13202 EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand GO:0007165 signal transduction GO:0005509//GO:0005515 calcium ion binding//protein binding GO:0005578 proteinaceous extracellular matrix KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-8309.59214 BF_2 299.68 3.10 4332 546682907 ERL92786.1 1051 3.8e-111 hypothetical protein D910_10094 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P53184 285 1.0e-23 Nicotinamidase OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PNC1 PE=1 SV=1 PF13833//PF13405//PF13499//PF12763//PF00036//PF12861//PF13202//PF00857 EF-hand domain pair//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//EF hand//Anaphase-promoting complex subunit 11 RING-H2 finger//EF hand//Isochorismatase family GO:0008152//GO:0016567 metabolic process//protein ubiquitination GO:0005509//GO:0003824//GO:0005515//GO:0004842 calcium ion binding//catalytic activity//protein binding//ubiquitin-protein transferase activity GO:0005680 anaphase-promoting complex KOG4003 Pyrazinamidase/nicotinamidase PNC1 Cluster-8309.59216 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59229 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59233 BF_2 19.36 0.46 2055 642919805 XP_008192075.1 807 3.5e-83 PREDICTED: nuclear transcription factor Y subunit alpha isoform X2 [Tribolium castaneum] 642919804 XM_008193853.1 68 1.4641e-24 PREDICTED: Tribolium castaneum nuclear transcription factor Y subunit alpha (LOC661458), transcript variant X2, mRNA K08064 NFYA nuclear transcription factor Y, alpha http://www.genome.jp/dbget-bin/www_bget?ko:K08064 P23511 365 2.6e-33 Nuclear transcription factor Y subunit alpha OS=Homo sapiens GN=NFYA PE=1 SV=2 PF00737//PF11525//PF02045 Photosystem II 10 kDa phosphoprotein//Copper resistance protein K//CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B GO:0006355//GO:0015979//GO:0050821 regulation of transcription, DNA-templated//photosynthesis//protein stabilization GO:0046872//GO:0003700//GO:0042301 metal ion binding//transcription factor activity, sequence-specific DNA binding//phosphate ion binding GO:0009523//GO:0016020//GO:0005667 photosystem II//membrane//transcription factor complex KOG1561 CCAAT-binding factor, subunit B (HAP2) Cluster-8309.59235 BF_2 120.02 2.66 2172 546684923 ERL94505.1 1330 8.5e-144 hypothetical protein D910_11782 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q29J90 590 2.2e-59 G-protein coupled receptor moody OS=Drosophila pseudoobscura pseudoobscura GN=moody PE=3 SV=2 PF02364//PF00001//PF13903 1,3-beta-glucan synthase component//7 transmembrane receptor (rhodopsin family)//PMP-22/EMP/MP20/Claudin tight junction GO:0005982//GO:0005985//GO:0006075//GO:0007186 starch metabolic process//sucrose metabolic process//(1->3)-beta-D-glucan biosynthetic process//G-protein coupled receptor signaling pathway GO:0003843//GO:0004930 1,3-beta-D-glucan synthase activity//G-protein coupled receptor activity GO:0016021//GO:0000148//GO:0016020 integral component of membrane//1,3-beta-D-glucan synthase complex//membrane -- -- Cluster-8309.59247 BF_2 49.48 0.72 3145 15450324 AAK96031.1 912 3.6e-95 homeodomain transcription factor Prothoraxless [Tribolium castaneum]>gi|270002803|gb|EEZ99250.1| antennapedia [Tribolium castaneum] 86515363 NM_001039416.1 265 6.93437e-134 Tribolium castaneum prothoraxless (Ptl), mRNA >gnl|BL_ORD_ID|908858 Tribolium castaneum prothoraxless mRNA, complete cds K09307 HOX_7 homeobox protein HoxA/B7 http://www.genome.jp/dbget-bin/www_bget?ko:K09307 P02833 379 9.5e-35 Homeotic protein antennapedia OS=Drosophila melanogaster GN=Antp PE=1 SV=1 PF03153//PF00046 Transcription factor IIA, alpha/beta subunit//Homeobox domain GO:0006367 transcription initiation from RNA polymerase II promoter GO:0003677 DNA binding GO:0005672 transcription factor TFIIA complex -- -- Cluster-8309.59248 BF_2 9.79 0.31 1594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59250 BF_2 108.53 0.89 5388 91085393 XP_966738.1 3860 0.0e+00 PREDICTED: Hermansky-Pudlak syndrome 3 protein homolog [Tribolium castaneum]>gi|270008408|gb|EFA04856.1| hypothetical protein TcasGA2_TC014910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q969F9 337 1.2e-29 Hermansky-Pudlak syndrome 3 protein OS=Homo sapiens GN=HPS3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59252 BF_2 91.41 0.75 5418 91085393 XP_966738.1 3854 0.0e+00 PREDICTED: Hermansky-Pudlak syndrome 3 protein homolog [Tribolium castaneum]>gi|270008408|gb|EFA04856.1| hypothetical protein TcasGA2_TC014910 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q969F9 337 1.2e-29 Hermansky-Pudlak syndrome 3 protein OS=Homo sapiens GN=HPS3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59257 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59261 BF_2 130.22 3.17 2006 546678907 ERL89445.1 1731 2.5e-190 hypothetical protein D910_06812 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 953 1.7e-101 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF03015//PF01073//PF00106//PF01118//PF01370 Male sterility protein//3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//Semialdehyde dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0051287//GO:0016491//GO:0003824//GO:0050662//GO:0003854//GO:0016620//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.59263 BF_2 56.44 1.35 2039 546678907 ERL89445.1 1731 2.5e-190 hypothetical protein D910_06812 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 A1ZAI5 953 1.7e-101 Putative fatty acyl-CoA reductase CG5065 OS=Drosophila melanogaster GN=CG5065 PE=3 SV=1 PF01370//PF01118//PF00106//PF01073//PF03015 NAD dependent epimerase/dehydratase family//Semialdehyde dehydrogenase, NAD binding domain//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//Male sterility protein GO:0008152//GO:0008210//GO:0008209//GO:0006694//GO:0055114//GO:0008207 metabolic process//estrogen metabolic process//androgen metabolic process//steroid biosynthetic process//oxidation-reduction process//C21-steroid hormone metabolic process GO:0016616//GO:0051287//GO:0016491//GO:0003824//GO:0050662//GO:0003854//GO:0016620//GO:0080019 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//oxidoreductase activity//catalytic activity//coenzyme binding//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//fatty-acyl-CoA reductase (alcohol-forming) activity -- -- KOG1221 Acyl-CoA reductase Cluster-8309.59265 BF_2 7.34 0.31 1291 546678907 ERL89445.1 360 1.5e-31 hypothetical protein D910_06812 [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q960W6 200 2.2e-14 Putative fatty acyl-CoA reductase CG8306 OS=Drosophila melanogaster GN=CG8306 PE=2 SV=1 PF08254//PF03125//PF03015 Threonine leader peptide//C. elegans Sre G protein-coupled chemoreceptor//Male sterility protein GO:0007606//GO:0031554//GO:0009088//GO:0031556 sensory perception of chemical stimulus//regulation of DNA-templated transcription, termination//threonine biosynthetic process//transcriptional attenuation by ribosome GO:0080019 fatty-acyl-CoA reductase (alcohol-forming) activity GO:0016021 integral component of membrane -- -- Cluster-8309.59269 BF_2 103.00 3.85 1406 91093719 XP_967705.1 374 3.9e-33 PREDICTED: probable small nuclear ribonucleoprotein G [Tribolium castaneum]>gi|270012988|gb|EFA09436.1| hypothetical protein TcasGA2_TC010648 [Tribolium castaneum] -- -- -- -- -- K11099 SNRPG, SMG small nuclear ribonucleoprotein G http://www.genome.jp/dbget-bin/www_bget?ko:K11099 Q9VXE0 329 2.7e-29 Probable small nuclear ribonucleoprotein G OS=Drosophila melanogaster GN=SmG PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1780 Small Nuclear ribonucleoprotein G Cluster-8309.59270 BF_2 13.71 0.69 1123 478249917 ENN70424.1 1427 2.5e-155 hypothetical protein YQE_12929, partial [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 861 4.4e-91 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0007268//GO:0006811 signal transduction//synaptic transmission//ion transport GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.59273 BF_2 24.31 0.91 1401 478249917 ENN70424.1 1418 3.4e-154 hypothetical protein YQE_12929, partial [Dendroctonus ponderosae] -- -- -- -- -- K05202 GRIK2 glutamate receptor, ionotropic kainate 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05202 P39087 861 5.4e-91 Glutamate receptor ionotropic, kainate 2 OS=Mus musculus GN=Grik2 PE=1 SV=4 PF10613//PF00060 Ligated ion channel L-glutamate- and glycine-binding site//Ligand-gated ion channel GO:0007165//GO:0006811//GO:0007268 signal transduction//ion transport//synaptic transmission GO:0005234//GO:0004970 extracellular-glutamate-gated ion channel activity//ionotropic glutamate receptor activity GO:0016020 membrane -- -- Cluster-8309.59280 BF_2 27.62 0.89 1584 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00093 von Willebrand factor type C domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59281 BF_2 132.54 2.07 2962 270001558 EEZ98005.1 1757 3.5e-193 hypothetical protein TcasGA2_TC000404 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1G0 226 4.9e-17 Zinc finger protein 687 OS=Homo sapiens GN=ZNF687 PE=1 SV=1 PF00096//PF13465//PF16622//PF13912//PF09520 Zinc finger, C2H2 type//Zinc-finger double domain//zinc-finger C2H2-type//C2H2-type zinc finger//Type II restriction endonuclease, TdeIII GO:0009307//GO:0006308 DNA restriction-modification system//DNA catabolic process GO:0009036//GO:0003677//GO:0046872 Type II site-specific deoxyribonuclease activity//DNA binding//metal ion binding GO:0009359 Type II site-specific deoxyribonuclease complex -- -- Cluster-8309.59285 BF_2 1.00 0.60 352 805770839 XP_012136490.1 159 8.3e-09 PREDICTED: transketolase isoform X2 [Megachile rotundata] -- -- -- -- -- K00615 E2.2.1.1, tktA, tktB transketolase http://www.genome.jp/dbget-bin/www_bget?ko:K00615 Q5R4C1 126 2.3e-06 Transketolase OS=Pongo abelii GN=TKT PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0523 Transketolase Cluster-8309.59287 BF_2 16.66 0.57 1517 642922347 XP_973693.2 649 5.5e-65 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 433 2.5e-41 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF01372//PF00664 Melittin//ABC transporter transmembrane region GO:0006810//GO:0045859//GO:0055085 transport//regulation of protein kinase activity//transmembrane transport GO:0005524//GO:0004860//GO:0042626 ATP binding//protein kinase inhibitor activity//ATPase activity, coupled to transmembrane movement of substances GO:0016021//GO:0005576 integral component of membrane//extracellular region KOG0054 Multidrug resistance-associated protein/mitoxantrone resistance protein, ABC superfamily Cluster-8309.59293 BF_2 9.77 0.39 1331 478254436 ENN74688.1 295 5.4e-24 hypothetical protein YQE_08805, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03708 Avian retrovirus envelope protein, gp85 -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8309.59296 BF_2 3.00 0.34 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59297 BF_2 152.48 6.45 1276 642915964 XP_008190829.1 983 8.6e-104 PREDICTED: oxysterol-binding protein-related protein 11 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CI95 316 7.8e-28 Oxysterol-binding protein-related protein 11 OS=Mus musculus GN=Osbpl11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59313 BF_2 2.00 0.37 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59314 BF_2 22.00 0.47 2255 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.59316 BF_2 14.00 0.36 1899 270015440 EFA11888.1 246 3.7e-18 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59317 BF_2 2.00 0.44 478 270015440 EFA11888.1 327 3.7e-28 hypothetical protein TcasGA2_TC016001 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8K259 203 3.7e-15 Gypsy retrotransposon integrase-like protein 1 OS=Mus musculus GN=Gin1 PE=2 SV=2 PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.5932 BF_2 7.00 0.34 1138 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59327 BF_2 221.00 9.16 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00041//PF16656 Fibronectin type III domain//Purple acid Phosphatase, N-terminal domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.59332 BF_2 108.73 2.06 2495 91079362 XP_970302.1 1401 5.7e-152 PREDICTED: islet cell autoantigen 1 [Tribolium castaneum]>gi|270003491|gb|EEZ99938.1| hypothetical protein TcasGA2_TC002734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63054 650 2.8e-66 Islet cell autoantigen 1 OS=Rattus norvegicus GN=Ica1 PE=2 SV=2 PF06456 Arfaptin-like domain -- -- GO:0019904 protein domain specific binding -- -- KOG3891 Secretory vesicle-associated protein ICA69, contains Arfaptin domain Cluster-8309.59340 BF_2 98.76 1.81 2568 189237665 XP_001812360.1 664 1.7e-66 PREDICTED: RNA-binding protein 34 [Tribolium castaneum]>gi|270007816|gb|EFA04264.1| hypothetical protein TcasGA2_TC014554 [Tribolium castaneum] -- -- -- -- -- K14837 NOP12 nucleolar protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K14837 P42696 339 3.4e-30 RNA-binding protein 34 OS=Homo sapiens GN=RBM34 PE=1 SV=2 PF04258//PF16367//PF00076 Signal peptide peptidase//RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0004190 nucleic acid binding//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG0118 FOG: RRM domain Cluster-8309.59346 BF_2 5.00 0.46 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59351 BF_2 21.08 0.36 2744 91084285 XP_971581.1 904 2.7e-94 PREDICTED: uncharacterized protein LOC660239 isoform X2 [Tribolium castaneum]>gi|270008748|gb|EFA05196.1| hypothetical protein TcasGA2_TC015330 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00688 TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.59352 BF_2 100.55 1.70 2761 642925259 XP_008194483.1 710 8.4e-72 PREDICTED: uncharacterized protein LOC660239 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00688 TGF-beta propeptide GO:0008283//GO:0007165//GO:0040007 cell proliferation//signal transduction//growth GO:0008083 growth factor activity -- -- -- -- Cluster-8309.59358 BF_2 14.44 0.37 1898 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00236 Glycoprotein hormone GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.59359 BF_2 31.00 0.78 1942 -- -- -- -- -- 764020144 NR_002819.3 1920 0 Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59364 BF_2 229.53 6.09 1864 642924941 XP_967306.2 1074 3.5e-114 PREDICTED: uncharacterized protein LOC658255 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P21369 234 3.7e-18 Pyrazinamidase/nicotinamidase OS=Escherichia coli (strain K12) GN=pncA PE=3 SV=1 PF00857//PF13202//PF09402//PF00036//PF12763//PF10591//PF13833//PF13405//PF13499 Isochorismatase family//EF hand//Man1-Src1p-C-terminal domain//EF hand//Cytoskeletal-regulatory complex EF hand//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain//EF-hand domain pair GO:0008152//GO:0007165 metabolic process//signal transduction GO:0005515//GO:0003824//GO:0005509 protein binding//catalytic activity//calcium ion binding GO:0005639//GO:0005578 integral component of nuclear inner membrane//proteinaceous extracellular matrix KOG4003 Pyrazinamidase/nicotinamidase PNC1 Cluster-8309.59375 BF_2 24.77 1.86 844 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59378 BF_2 19.58 0.57 1736 795117684 XP_011883383.1 198 1.2e-12 PREDICTED: E3 ubiquitin-protein ligase UBR3 [Vollenhovia emeryi] -- -- -- -- -- K11978 UBR3 E3 ubiquitin-protein ligase UBR3 http://www.genome.jp/dbget-bin/www_bget?ko:K11978 Q6ZT12 146 5.5e-08 E3 ubiquitin-protein ligase UBR3 OS=Homo sapiens GN=UBR3 PE=2 SV=2 PF04434 SWIM zinc finger -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.59382 BF_2 70.00 6.14 764 91090326 XP_966482.1 283 7.6e-23 PREDICTED: general transcription factor IIF subunit 1 [Tribolium castaneum]>gi|270013422|gb|EFA09870.1| hypothetical protein TcasGA2_TC012018 [Tribolium castaneum] -- -- -- -- -- K15223 UAF30, SPP27 upstream activation factor subunit UAF30 http://www.genome.jp/dbget-bin/www_bget?ko:K15223 -- -- -- -- PF01496//PF02201//PF04977 V-type ATPase 116kDa subunit family//SWIB/MDM2 domain//Septum formation initiator GO:0015991//GO:0007049//GO:0015992 ATP hydrolysis coupled proton transport//cell cycle//proton transport GO:0005515//GO:0015078//GO:0003677 protein binding//hydrogen ion transmembrane transporter activity//DNA binding GO:0033179 proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.59386 BF_2 46.45 1.54 1552 189233571 XP_967872.2 354 9.0e-31 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TBH0 146 4.9e-08 Arrestin domain-containing protein 2 OS=Homo sapiens GN=ARRDC2 PE=2 SV=2 PF02826 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114 oxidation-reduction process GO:0051287 NAD binding -- -- -- -- Cluster-8309.59389 BF_2 30.07 0.71 2047 91093748 XP_969297.1 997 3.3e-105 PREDICTED: cerebellar degeneration-related protein 2-like isoform X1 [Tribolium castaneum]>gi|270013015|gb|EFA09463.1| hypothetical protein TcasGA2_TC010679 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86X02 334 1.0e-29 Cerebellar degeneration-related protein 2-like OS=Homo sapiens GN=CDR2L PE=1 SV=2 PF08172//PF00170//PF06156//PF05791//PF06009//PF04111//PF04977//PF08941//PF05929//PF01025//PF17078//PF10473//PF07926 CASP C terminal//bZIP transcription factor//Protein of unknown function (DUF972)//Bacillus haemolytic enterotoxin (HBL)//Laminin Domain II//Autophagy protein Apg6//Septum formation initiator//USP8 interacting//Phage capsid scaffolding protein (GPO) serine peptidase//GrpE//SWI5-dependent HO expression protein 3//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein GO:0019069//GO:0007155//GO:0016567//GO:0048309//GO:0051028//GO:0006891//GO:0006457//GO:0007049//GO:0006260//GO:0006355//GO:0006606//GO:0006914//GO:0009405 viral capsid assembly//cell adhesion//protein ubiquitination//endoplasmic reticulum inheritance//mRNA transport//intra-Golgi vesicle-mediated transport//protein folding//cell cycle//DNA replication//regulation of transcription, DNA-templated//protein import into nucleus//autophagy//pathogenesis GO:0042803//GO:0003700//GO:0000774//GO:0051087//GO:0016881//GO:0043565//GO:0045502//GO:0008134//GO:0031386 protein homodimerization activity//transcription factor activity, sequence-specific DNA binding//adenyl-nucleotide exchange factor activity//chaperone binding//acid-amino acid ligase activity//sequence-specific DNA binding//dynein binding//transcription factor binding//protein tag GO:0016020//GO:0030173//GO:0005667//GO:0030286 membrane//integral component of Golgi membrane//transcription factor complex//dynein complex -- -- Cluster-8309.59394 BF_2 5.00 14.42 271 676451318 XP_009052666.1 141 7.8e-07 hypothetical protein LOTGIDRAFT_71630, partial [Lottia gigantea]>gi|556107994|gb|ESO96646.1| hypothetical protein LOTGIDRAFT_71630, partial [Lottia gigantea] 462334797 APGK01038457.1 85 6.12098e-35 Dendroctonus ponderosae Seq01038467, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59396 BF_2 37.49 1.35 1450 542171132 XP_003442380.2 374 4.0e-33 PREDICTED: tyrosine-protein kinase Fes/Fps-like isoform X1 [Oreochromis niloticus] -- -- -- -- -- K05728 CSK c-src tyrosine kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05728 Q8CBF3 329 2.7e-29 Ephrin type-B receptor 1 OS=Mus musculus GN=Ephb1 PE=1 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.59399 BF_2 6.00 0.58 722 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59406 BF_2 25.66 2.65 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59409 BF_2 5.00 0.60 634 553041307 AGY54953.1 193 1.7e-12 encapsulation-relating protein [Monochamus alternatus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59413 BF_2 99.28 0.82 5359 154416763 XP_001581403.1 156 2.8e-07 viral A-type inclusion protein [Trichomonas vaginalis G3]>gi|121915630|gb|EAY20417.1| viral A-type inclusion protein, putative [Trichomonas vaginalis G3] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59418 BF_2 59.00 0.57 4600 642916983 XP_008199582.1 2574 1.0e-287 PREDICTED: DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 [Tribolium castaneum] -- -- -- -- -- K10742 DNA2 DNA replication ATP-dependent helicase Dna2 http://www.genome.jp/dbget-bin/www_bget?ko:K10742 E1BMP7 1405 1.5e-153 DNA replication ATP-dependent helicase/nuclease DNA2 OS=Bos taurus GN=DNA2 PE=3 SV=3 PF02562//PF01443//PF02606 PhoH-like protein//Viral (Superfamily 1) RNA helicase//Tetraacyldisaccharide-1-P 4'-kinase GO:0009103//GO:0015940//GO:0009245 lipopolysaccharide biosynthetic process//pantothenate biosynthetic process//lipid A biosynthetic process GO:0009029//GO:0005524 tetraacyldisaccharide 4'-kinase activity//ATP binding -- -- KOG1805 DNA replication helicase Cluster-8309.59432 BF_2 7.00 1.52 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59435 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59438 BF_2 13.00 0.53 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03127 GAT domain GO:0006886 intracellular protein transport -- -- GO:0005622 intracellular -- -- Cluster-8309.59444 BF_2 6.00 3.82 348 642925814 XP_970128.3 319 2.3e-27 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 232 1.2e-18 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01073//PF00106//PF01370//PF12242 3-beta hydroxysteroid dehydrogenase/isomerase family//short chain dehydrogenase//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 metabolic process//estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0016491//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//oxidoreductase activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- -- -- Cluster-8309.59447 BF_2 1.00 1.24 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59449 BF_2 13.00 11.27 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59460 BF_2 11.70 0.33 1784 270016030 EFA12478.1 417 5.1e-38 hypothetical protein TcasGA2_TC001502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q03277 163 6.0e-10 Retrovirus-related Pol polyprotein from type-1 retrotransposable element R1 (Fragment) OS=Bradysia coprophila PE=3 SV=1 -- -- -- -- -- -- -- -- KOG1075 FOG: Reverse transcriptase Cluster-8309.59462 BF_2 165.60 2.61 2939 642924690 XP_008194399.1 1005 5.6e-106 PREDICTED: probable G-protein coupled receptor Mth-like 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 213 1.6e-15 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002//PF09398 7 transmembrane receptor (Secretin family)//FOP N terminal dimerisation domain GO:0007186//GO:0034453 G-protein coupled receptor signaling pathway//microtubule anchoring GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0005815 integral component of membrane//microtubule organizing center -- -- Cluster-8309.59463 BF_2 15.55 0.87 1033 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59474 BF_2 2.00 0.81 389 313239184 CBY14143.1 228 9.2e-17 unnamed protein product [Oikopleura dioica] 407313393 JX680695.1 323 4.55222e-167 Uncultured bacterium clone LFC61 16S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59476 BF_2 1.00 0.63 349 313238136 CBY13234.1 190 2.1e-12 unnamed protein product [Oikopleura dioica] 273550228 GQ164742.1 336 2.39773e-174 Uncultured bacterium clone 2A287 16S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59485 BF_2 58.44 1.16 2394 91081457 XP_974014.1 2265 3.6e-252 PREDICTED: probable cytochrome P450 301a1, mitochondrial [Tribolium castaneum]>gi|270006458|gb|EFA02906.1| cytochrome P450 301A1 [Tribolium castaneum] 642920930 XM_968921.2 295 1.1075e-150 PREDICTED: Tribolium castaneum cytochrome P450 301A1 (LOC662845), mRNA -- -- -- -- Q9V6D6 1858 2.3e-206 Probable cytochrome P450 301a1, mitochondrial OS=Drosophila melanogaster GN=Cyp301a1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009055//GO:0016705//GO:0020037//GO:0004497//GO:0005506 electron carrier activity//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//monooxygenase activity//iron ion binding -- -- KOG0159 Cytochrome P450 CYP11/CYP12/CYP24/CYP27 subfamilies Cluster-8309.59488 BF_2 19.11 0.44 2102 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59489 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5949 BF_2 3.00 0.55 516 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59496 BF_2 67.98 1.71 1948 189235279 XP_973810.2 1316 3.2e-142 PREDICTED: probable cytochrome P450 4aa1 [Tribolium castaneum] -- -- -- -- -- K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 Q9V7G5 1105 3.8e-119 Probable cytochrome P450 4aa1 OS=Drosophila melanogaster GN=Cyp4aa1 PE=2 SV=2 PF00067//PF03806 Cytochrome P450//AbgT putative transporter family GO:0015814//GO:0006811//GO:1902604//GO:0055114//GO:0015846 p-aminobenzoyl-glutamate transport//ion transport//p-aminobenzoyl-glutamate transmembrane transport//oxidation-reduction process//polyamine transport GO:0015558//GO:0005506//GO:0020037//GO:0016705 p-aminobenzoyl-glutamate uptake transmembrane transporter activity//iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.59503 BF_2 45.93 0.32 6243 478253532 ENN73850.1 6595 0.0e+00 hypothetical protein YQE_09542, partial [Dendroctonus ponderosae]>gi|546685405|gb|ERL94918.1| hypothetical protein D910_12190 [Dendroctonus ponderosae] 642937163 XM_008200496.1 374 0 PREDICTED: Tribolium castaneum cadherin-89D (LOC658847), mRNA -- -- -- -- Q9VEU1 1638 1.9e-180 Cadherin-89D OS=Drosophila melanogaster GN=Cad89D PE=2 SV=3 PF00028//PF09107 Cadherin domain//Elongation factor SelB, winged helix GO:0001514//GO:0006448//GO:0007156 selenocysteine incorporation//regulation of translational elongation//homophilic cell adhesion via plasma membrane adhesion molecules GO:0003746//GO:0005509//GO:0005525//GO:0003723 translation elongation factor activity//calcium ion binding//GTP binding//RNA binding GO:0005737//GO:0016020//GO:0005840 cytoplasm//membrane//ribosome -- -- Cluster-8309.59507 BF_2 20.63 0.48 2068 642930236 XP_008196311.1 289 4.1e-23 PREDICTED: poly [ADP-ribose] polymerase 12-like isoform X1 [Tribolium castaneum]>gi|270009442|gb|EFA05890.1| hypothetical protein TcasGA2_TC008702 [Tribolium castaneum] -- -- -- -- -- K15259 PARP7S poly http://www.genome.jp/dbget-bin/www_bget?ko:K15259 Q8CFF0 153 1.0e-08 Poly [ADP-ribose] polymerase 11 OS=Mus musculus GN=Parp11 PE=2 SV=1 PF00644//PF09036 Poly(ADP-ribose) polymerase catalytic domain//Bcr-Abl oncoprotein oligomerisation domain GO:0009069//GO:0006468//GO:0016310//GO:0007165 serine family amino acid metabolic process//protein phosphorylation//phosphorylation//signal transduction GO:0003950//GO:0004674//GO:0005096 NAD+ ADP-ribosyltransferase activity//protein serine/threonine kinase activity//GTPase activator activity -- -- -- -- Cluster-8309.59512 BF_2 23.00 1.83 813 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59517 BF_2 8.71 0.93 680 17646748 AAL41023.1 399 2.4e-36 juvenile hormone esterase [Tenebrio molitor] -- -- -- -- -- -- -- -- -- B2D0J5 129 2.0e-06 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1516 Carboxylesterase and related proteins Cluster-8309.59520 BF_2 4.00 0.70 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59526 BF_2 10.95 0.40 1433 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59531 BF_2 22.45 1.25 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59532 BF_2 94.17 1.68 2635 91083957 XP_975021.1 800 2.9e-82 PREDICTED: caldesmon [Tribolium castaneum]>gi|270006722|gb|EFA03170.1| hypothetical protein TcasGA2_TC013090 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09002 147 6.3e-08 Stathmin-2-B OS=Xenopus laevis GN=stmn2-b PE=2 SV=1 PF04513//PF14372//PF00836//PF01442 Baculovirus polyhedron envelope protein, PEP, C terminus//Domain of unknown function (DUF4413)//Stathmin family//Apolipoprotein A1/A4/E domain GO:0031110//GO:0006869//GO:0042157 regulation of microtubule polymerization or depolymerization//lipid transport//lipoprotein metabolic process GO:0005198//GO:0003677//GO:0008289 structural molecule activity//DNA binding//lipid binding GO:0005576//GO:0019031//GO:0019028 extracellular region//viral envelope//viral capsid -- -- Cluster-8309.59542 BF_2 19.83 0.45 2142 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12297 Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- -- -- -- -- Cluster-8309.59543 BF_2 69.10 0.78 3971 642921912 XP_008192941.1 204 5.7e-13 PREDICTED: uncharacterized protein LOC103312898 [Tribolium castaneum]>gi|270007368|gb|EFA03816.1| hypothetical protein TcasGA2_TC013930 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00876//PF12297 Innexin//Ellis van Creveld protein 2 like protein GO:0007224 smoothened signaling pathway -- -- GO:0005921 gap junction -- -- Cluster-8309.59546 BF_2 15.00 0.31 2292 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04805 E10-like protein conserved region GO:0055114 oxidation-reduction process GO:0016972 thiol oxidase activity -- -- -- -- Cluster-8309.5955 BF_2 7.86 0.39 1120 642912421 XP_008193352.1 262 3.0e-20 PREDICTED: serine protease snake-like [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 Q9VWU1 196 5.6e-14 Serine protease persephone OS=Drosophila melanogaster GN=psh PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.5956 BF_2 14.89 0.50 1535 270012759 EFA09207.1 634 3.0e-63 serine protease P66 [Tribolium castaneum] -- -- -- -- -- K01324 KLKB1 plasma kallikrein http://www.genome.jp/dbget-bin/www_bget?ko:K01324 P05049 413 5.3e-39 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.59561 BF_2 224.23 5.08 2133 642924692 XP_008194400.1 969 6.0e-102 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VS77 200 3.7e-14 Probable G-protein coupled receptor Mth-like 6 OS=Drosophila melanogaster GN=mthl6 PE=3 SV=2 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.59566 BF_2 6.00 1.84 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59569 BF_2 22.85 0.42 2550 189233571 XP_967872.2 433 1.0e-39 PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910232|ref|XP_008198495.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|642910234|ref|XP_008198500.1| PREDICTED: arrestin domain-containing protein 3 [Tribolium castaneum]>gi|270014628|gb|EFA11076.1| hypothetical protein TcasGA2_TC004672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D668 190 6.3e-13 Arrestin domain-containing protein 2 OS=Mus musculus GN=Arrdc2 PE=2 SV=1 PF06005 Protein of unknown function (DUF904) GO:0043093//GO:0000917 FtsZ-dependent cytokinesis//barrier septum assembly -- -- GO:0005737 cytoplasm -- -- Cluster-8309.59579 BF_2 15.16 0.97 943 189241705 XP_967022.2 652 1.5e-65 PREDICTED: neutral alpha-glucosidase C-like [Tribolium castaneum] -- -- -- -- -- K05546 GANAB alpha 1,3-glucosidase http://www.genome.jp/dbget-bin/www_bget?ko:K05546 Q94502 534 3.0e-53 Neutral alpha-glucosidase AB OS=Dictyostelium discoideum GN=modA PE=3 SV=1 PF01055 Glycosyl hydrolases family 31 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- KOG1066 Glucosidase II catalytic (alpha) subunit and related enzymes, glycosyl hydrolase family 31 Cluster-8309.59583 BF_2 74.61 2.73 1431 642932154 XP_975375.2 712 2.6e-72 PREDICTED: uncharacterized protein LOC664273 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12568//PF13673//PF08445//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.59585 BF_2 8.06 0.32 1355 642932154 XP_975375.2 377 1.7e-33 PREDICTED: uncharacterized protein LOC664273 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12568//PF13673//PF08445//PF00583//PF13508 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) family//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-8309.59586 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59590 BF_2 12.09 0.54 1229 607356256 EZA50796.1 1109 2.0e-118 Teneurin-3 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- O61307 742 3.0e-77 Teneurin-m OS=Drosophila melanogaster GN=Ten-m PE=1 SV=2 PF04863 Alliinase EGF-like domain -- -- GO:0016846 carbon-sulfur lyase activity -- -- KOG1225 Teneurin-1 and related extracellular matrix proteins, contain EGF-like repeats Cluster-8309.59592 BF_2 30.89 1.00 1583 546683069 ERL92930.1 479 2.9e-45 hypothetical protein D910_10235 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9JL89 209 2.5e-15 Ninjurin-2 OS=Mus musculus GN=Ninj2 PE=2 SV=1 PF01545//PF10192//PF02990//PF04923 Cation efflux family//Rhodopsin-like GPCR transmembrane domain//Endomembrane protein 70//Ninjurin GO:0019236//GO:0007155//GO:0006812//GO:0007186//GO:0042246//GO:0055085 response to pheromone//cell adhesion//cation transport//G-protein coupled receptor signaling pathway//tissue regeneration//transmembrane transport GO:0008324 cation transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59594 BF_2 4.00 0.84 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59598 BF_2 95.00 2.07 2208 642915509 XP_008190647.1 1285 1.4e-138 PREDICTED: glomulin [Tribolium castaneum]>gi|270003856|gb|EFA00304.1| hypothetical protein TcasGA2_TC003139 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q92990 557 1.5e-55 Glomulin OS=Homo sapiens GN=GLMN PE=1 SV=2 PF01844 HNH endonuclease -- -- GO:0004519//GO:0003676 endonuclease activity//nucleic acid binding -- -- -- -- Cluster-8309.596 BF_2 56.00 1.20 2246 873231363 CEM08610.1 491 1.7e-46 unnamed protein product [Vitrella brassicaformis CCMP3155] 761231605 KM881639.1 2246 0 Oryza glaberrima isolate 101328 chloroplast, complete genome K01358 clpP, CLPP ATP-dependent Clp protease, protease subunit http://www.genome.jp/dbget-bin/www_bget?ko:K01358 P0C313 1150 2.7e-124 ATP-dependent Clp protease proteolytic subunit OS=Oryza sativa subsp. indica GN=clpP PE=3 SV=1 PF00164//PF00806//PF00453 Ribosomal protein S12/S23//Pumilio-family RNA binding repeat//Ribosomal protein L20 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0019843//GO:0003723//GO:0003735 rRNA binding//RNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0840 ATP-dependent Clp protease, proteolytic subunit Cluster-8309.59606 BF_2 3.00 1.77 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59619 BF_2 10.00 0.36 1443 642929134 XP_008195706.1 1075 2.1e-114 PREDICTED: engrailed isoform X1 [Tribolium castaneum] 642929133 XM_008197484.1 221 9.04879e-110 PREDICTED: Tribolium castaneum engrailed (En), transcript variant X1, mRNA K09319 EN homeobox protein engrailed http://www.genome.jp/dbget-bin/www_bget?ko:K09319 P27610 668 1.3e-68 Homeobox protein invected OS=Bombyx mori GN=INV PE=2 SV=1 PF05920//PF01140//PF00046 Homeobox KN domain//Matrix protein (MA), p15//Homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0005198 DNA binding//structural molecule activity GO:0019028 viral capsid KOG0489 Transcription factor zerknullt and related HOX domain proteins Cluster-8309.59628 BF_2 81.63 1.68 2319 282847463 NP_001164280.1 2233 1.8e-248 archipelago [Tribolium castaneum] 532104130 XM_005337603.1 179 3.26855e-86 PREDICTED: Spermophilus tridecemlineatus F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase (Fbxw7), transcript variant X3, mRNA K10260 FBXW7, SEL10 F-box and WD-40 domain protein 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10260 Q9VZF4 1732 9.0e-192 F-box/WD repeat-containing protein 7 OS=Drosophila melanogaster GN=ago PE=1 SV=1 PF12937//PF06881//PF00400//PF00646 F-box-like//RNA polymerase II transcription factor SIII (Elongin) subunit A//WD domain, G-beta repeat//F-box domain GO:0006355 regulation of transcription, DNA-templated GO:0005515 protein binding GO:0016021//GO:0005634 integral component of membrane//nucleus KOG0274 Cdc4 and related F-box and WD-40 proteins Cluster-8309.59639 BF_2 52.00 3.07 996 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59640 BF_2 129.00 8.97 889 60678799 AAX33734.1 516 8.4e-50 MPA3 allergen [Periplaneta americana] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 O97399 497 5.5e-49 Trypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.5965 BF_2 26.99 0.79 1721 91078830 XP_971270.1 763 3.7e-78 PREDICTED: metallophosphoesterase domain-containing protein 1 [Tribolium castaneum]>gi|270004125|gb|EFA00573.1| hypothetical protein TcasGA2_TC003443 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q18161 345 4.5e-31 UPF0046 protein C25E10.12 OS=Caenorhabditis elegans GN=C25E10.12 PE=3 SV=1 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3947 Phosphoesterases Cluster-8309.59651 BF_2 2.00 0.51 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59668 BF_2 4.77 0.44 741 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59672 BF_2 34.51 2.55 854 449083364 NP_001263355.1 647 5.2e-65 dehydrogenase/reductase SDR family member 4 [Tribolium castaneum]>gi|270003836|gb|EFA00284.1| hypothetical protein TcasGA2_TC003117 [Tribolium castaneum] -- -- -- -- -- K11147 DHRS4 dehydrogenase/reductase SDR family member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11147 Q9GKX2 457 2.3e-44 Dehydrogenase/reductase SDR family member 4 (Fragment) OS=Oryctolagus cuniculus GN=DHRS4 PE=1 SV=1 PF00106//PF02737//PF01370 short chain dehydrogenase//3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//NAD dependent epimerase/dehydratase family GO:0055114//GO:0006552//GO:0006554//GO:0006568//GO:0006631//GO:0008152//GO:0006633//GO:0018874//GO:0006574//GO:0006550 oxidation-reduction process//leucine catabolic process//lysine catabolic process//tryptophan metabolic process//fatty acid metabolic process//metabolic process//fatty acid biosynthetic process//benzoate metabolic process//valine catabolic process//isoleucine catabolic process GO:0003857//GO:0016491//GO:0003824//GO:0050662 3-hydroxyacyl-CoA dehydrogenase activity//oxidoreductase activity//catalytic activity//coenzyme binding -- -- KOG0725 Reductases with broad range of substrate specificities Cluster-8309.59689 BF_2 2.00 0.40 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00111//PF06652 2Fe-2S iron-sulfur cluster binding domain//Methuselah N-terminus GO:0006118//GO:0007186//GO:0006950 obsolete electron transport//G-protein coupled receptor signaling pathway//response to stress GO:0004930//GO:0051536//GO:0009055 G-protein coupled receptor activity//iron-sulfur cluster binding//electron carrier activity -- -- -- -- Cluster-8309.59705 BF_2 8.65 0.34 1356 642939895 XP_008200229.1 534 1.1e-51 PREDICTED: tyrosine-protein phosphatase corkscrew isoform X2 [Tribolium castaneum] -- -- -- -- -- K07293 PTPN11 tyrosine-protein phosphatase non-receptor type 11 http://www.genome.jp/dbget-bin/www_bget?ko:K07293 Q06124 479 1.0e-46 Tyrosine-protein phosphatase non-receptor type 11 OS=Homo sapiens GN=PTPN11 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.59710 BF_2 39.72 0.44 4099 478263167 ENN81560.1 2839 0.0e+00 hypothetical protein YQE_02089, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NEN0 734 8.5e-76 Armadillo repeat-containing protein 2 OS=Homo sapiens GN=ARMC2 PE=2 SV=4 PF06372//PF00514 Gemin6 protein//Armadillo/beta-catenin-like repeat GO:0000245 spliceosomal complex assembly GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.59712 BF_2 33.44 0.37 4118 676426419 XP_009044617.1 755 7.6e-77 hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea]>gi|556116066|gb|ESP04718.1| hypothetical protein LOTGIDRAFT_170555 [Lottia gigantea] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 688 1.8e-70 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF16622//PF13465//PF00096//PF00130//PF01842 C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger double domain//Zinc finger, C2H2 type//Phorbol esters/diacylglycerol binding domain (C1 domain)//ACT domain GO:0008152//GO:0035556 metabolic process//intracellular signal transduction GO:0016597//GO:0046872 amino acid binding//metal ion binding -- -- -- -- Cluster-8309.59721 BF_2 64.97 1.92 1701 852800404 XP_012889433.1 663 1.5e-66 PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800407|ref|XP_012889434.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800410|ref|XP_012889435.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800413|ref|XP_012889436.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii]>gi|852800416|ref|XP_012889437.1| PREDICTED: zinc finger protein 26-like [Dipodomys ordii] 533131911 XM_005380929.1 41 1.23342e-09 PREDICTED: Chinchilla lanigera zinc finger protein 133 (Znf133), transcript variant X9, mRNA K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 631 3.1e-64 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13465//PF00096//PF00830//PF17123//PF13912//PF01780 Zinc-finger double domain//Zinc finger, C2H2 type//Ribosomal L28 family//RING-like zinc finger//C2H2-type zinc finger//Ribosomal L37ae protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0046872//GO:0008270//GO:0003735//GO:0005515 metal ion binding//zinc ion binding//structural constituent of ribosome//protein binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.59733 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59738 BF_2 2.00 0.51 450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59750 BF_2 90.22 1.69 2517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604//PF00341 Variant SH3 domain//PDGF/VEGF domain GO:0008283//GO:0040007//GO:0007165 cell proliferation//growth//signal transduction GO:0005515//GO:0008083 protein binding//growth factor activity GO:0016020 membrane -- -- Cluster-8309.59754 BF_2 233.61 14.90 943 290909033 ADD70031.1 343 1.0e-29 minus-C odorant binding protein 2 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01395//PF02416 PBP/GOBP family//mttA/Hcf106 family GO:0015031 protein transport GO:0005549//GO:0008565 odorant binding//protein transporter activity -- -- -- -- Cluster-8309.59756 BF_2 8.29 0.48 1003 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59759 BF_2 9.03 0.39 1260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59766 BF_2 67.40 0.84 3655 642939164 XP_008200361.1 2189 3.5e-243 PREDICTED: alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1 [Tribolium castaneum]>gi|270016358|gb|EFA12804.1| hypothetical protein TcasGA2_TC001867 [Tribolium castaneum] 752875257 XM_011256672.1 68 2.62223e-24 PREDICTED: Camponotus floridanus alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC105250520), transcript variant X5, mRNA K00736 MGAT2 alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00736 Q921V5 843 1.7e-88 Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat2 PE=2 SV=1 PF01121//PF02367//PF06414//PF05060//PF00437 Dephospho-CoA kinase//Threonylcarbamoyl adenosine biosynthesis protein TsaE//Zeta toxin//N-acetylglucosaminyltransferase II (MGAT2)//Type II/IV secretion system protein GO:0002949//GO:0015937//GO:0009312//GO:0015940//GO:0006810 tRNA threonylcarbamoyladenosine modification//coenzyme A biosynthetic process//oligosaccharide biosynthetic process//pantothenate biosynthetic process//transport GO:0016301//GO:0004140//GO:0005524//GO:0008455 kinase activity//dephospho-CoA kinase activity//ATP binding//alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity GO:0005795//GO:0016021 Golgi stack//integral component of membrane KOG2791 N-acetylglucosaminyltransferase Cluster-8309.59768 BF_2 16.52 1.92 647 728418383 AIY68367.1 330 2.3e-28 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59769 BF_2 5.00 0.35 892 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59773 BF_2 12.25 0.42 1511 91086405 XP_966655.1 405 1.1e-36 PREDICTED: retinol dehydrogenase 12 [Tribolium castaneum]>gi|270010298|gb|EFA06746.1| hypothetical protein TcasGA2_TC009680 [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8BYK4 239 7.8e-19 Retinol dehydrogenase 12 OS=Mus musculus GN=Rdh12 PE=2 SV=1 PF00106//PF12242 short chain dehydrogenase//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG1208 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) Cluster-8309.59777 BF_2 39.30 0.53 3382 91083749 XP_971342.1 1218 1.3e-130 PREDICTED: MPN domain-containing protein CG4751 isoform X1 [Tribolium castaneum]>gi|270006798|gb|EFA03246.1| hypothetical protein TcasGA2_TC013179 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VKJ1 890 5.7e-94 MPN domain-containing protein CG4751 OS=Drosophila melanogaster GN=CG4751 PE=1 SV=1 PF01398 JAB1/Mov34/MPN/PAD-1 ubiquitin protease -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.5978 BF_2 16.64 0.53 1593 91091418 XP_971893.1 820 8.5e-85 PREDICTED: protein-associating with the carboxyl-terminal domain of ezrin [Tribolium castaneum]>gi|270000964|gb|EEZ97411.1| hypothetical protein TcasGA2_TC011240 [Tribolium castaneum] -- -- -- -- -- K17542 SCYL3 SCY1-like protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17542 Q9DBQ7 252 2.6e-20 Protein-associating with the carboxyl-terminal domain of ezrin OS=Mus musculus GN=Scyl3 PE=2 SV=3 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1243 Protein kinase Cluster-8309.59794 BF_2 4.00 0.41 698 546675362 ERL86572.1 355 3.1e-31 hypothetical protein D910_03979 [Dendroctonus ponderosae] -- -- -- -- -- K01530 E3.6.3.1 phospholipid-translocating ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K01530 Q9GKS6 189 2.3e-13 Probable phospholipid-transporting ATPase VD (Fragment) OS=Macaca fascicularis GN=ATP10D PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0206 P-type ATPase Cluster-8309.59796 BF_2 2.00 0.35 524 91090021 XP_967356.1 209 2.0e-14 PREDICTED: peroxiredoxin-1 [Tribolium castaneum]>gi|270014285|gb|EFA10733.1| hypothetical protein TcasGA2_TC012328 [Tribolium castaneum] -- -- -- -- -- K03386 E1.11.1.15, PRDX, ahpC peroxiredoxin (alkyl hydroperoxide reductase subunit C) http://www.genome.jp/dbget-bin/www_bget?ko:K03386 Q9V3P0 159 5.1e-10 Peroxiredoxin 1 OS=Drosophila melanogaster GN=Jafrac1 PE=1 SV=1 PF00578//PF08534 AhpC/TSA family//Redoxin GO:0055114 oxidation-reduction process GO:0016491//GO:0016209//GO:0051920 oxidoreductase activity//antioxidant activity//peroxiredoxin activity -- -- KOG0852 Alkyl hydroperoxide reductase, thiol specific antioxidant and related enzymes Cluster-8309.59801 BF_2 46.38 1.05 2128 91082815 XP_968750.1 1726 1.0e-189 PREDICTED: beta-galactoside alpha-2,6-sialyltransferase 1 [Tribolium castaneum]>gi|270007588|gb|EFA04036.1| hypothetical protein TcasGA2_TC014265 [Tribolium castaneum] -- -- -- -- -- K00779 SIAT2, ST6GAL2 beta-galactoside alpha2,6-sialyltransferase (sialyltransferase 2) http://www.genome.jp/dbget-bin/www_bget?ko:K00779 Q92182 682 4.7e-70 Beta-galactoside alpha-2,6-sialyltransferase 1 OS=Gallus gallus GN=ST6GAL1 PE=2 SV=1 PF01192//PF00777 RNA polymerase Rpb6//Glycosyltransferase family 29 (sialyltransferase) GO:0006144//GO:0006351//GO:0006206//GO:0006486 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//protein glycosylation GO:0008373//GO:0003677//GO:0003899 sialyltransferase activity//DNA binding//DNA-directed RNA polymerase activity GO:0005730//GO:0030173 nucleolus//integral component of Golgi membrane KOG2692 Sialyltransferase Cluster-8309.59802 BF_2 1.00 10.51 232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59805 BF_2 81.28 4.04 1128 642935650 XP_008198099.1 1181 8.3e-127 PREDICTED: post-GPI attachment to proteins factor 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7K0P4 748 5.5e-78 Post-GPI attachment to proteins factor 3 OS=Drosophila melanogaster GN=PGAP3 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2970 Predicted membrane protein Cluster-8309.59810 BF_2 40.79 0.33 5411 642923601 XP_008193575.1 651 1.1e-64 PREDICTED: uncharacterized protein LOC103313062 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q54G05 169 3.7e-10 Putative leucine-rich repeat-containing protein DDB_G0290503 OS=Dictyostelium discoideum GN=DDB_G0290503 PE=3 SV=1 PF15957//PF00097//PF14634//PF13639//PF11789 Commissureless//Zinc finger, C3HC4 type (RING finger)//zinc-RING finger domain//Ring finger domain//Zinc-finger of the MIZ type in Nse subunit GO:0007411 axon guidance GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- -- -- Cluster-8309.59814 BF_2 1.00 3.86 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59827 BF_2 42.39 0.72 2743 332374612 AEE62447.1 1251 1.5e-134 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 756 1.6e-78 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF01321//PF01758 Creatinase/Prolidase N-terminal domain//Sodium Bile acid symporter family -- -- GO:0016787 hydrolase activity GO:0016020 membrane -- -- Cluster-8309.59832 BF_2 28.45 0.40 3274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04066 Multiple resistance and pH regulation protein F (MrpF / PhaF) GO:0006811//GO:0034220 ion transport//ion transmembrane transport GO:0015075 ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59834 BF_2 6.00 5.47 324 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59835 BF_2 5.00 4.27 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59842 BF_2 6.60 2.80 384 478259670 ENN79514.1 455 4.3e-43 hypothetical protein YQE_03977, partial [Dendroctonus ponderosae]>gi|546682940|gb|ERL92819.1| hypothetical protein D910_10127 [Dendroctonus ponderosae] -- -- -- -- -- K00966 GMPP mannose-1-phosphate guanylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00966 Q8BTZ7 423 9.1e-41 Mannose-1-phosphate guanyltransferase beta OS=Mus musculus GN=Gmppb PE=2 SV=1 PF00483 Nucleotidyl transferase GO:0009058 biosynthetic process GO:0016779 nucleotidyltransferase activity -- -- KOG1322 GDP-mannose pyrophosphorylase/mannose-1-phosphate guanylyltransferase Cluster-8309.59850 BF_2 221.15 6.16 1788 642939169 XP_008200363.1 1187 2.7e-127 PREDICTED: solute carrier family 41 member 1 [Tribolium castaneum] -- -- -- -- -- K15122 SLC41A solute carrier family 41 http://www.genome.jp/dbget-bin/www_bget?ko:K15122 Q8BJA2 646 5.9e-66 Solute carrier family 41 member 1 OS=Mus musculus GN=Slc41a1 PE=2 SV=1 PF01769 Divalent cation transporter GO:0006812 cation transport GO:0008324 cation transmembrane transporter activity -- -- KOG3788 Predicted divalent cation transporter Cluster-8309.59855 BF_2 10.54 0.35 1530 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59856 BF_2 6.00 1.14 508 270014457 EFA10905.1 288 1.3e-23 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59861 BF_2 37.00 10.50 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59862 BF_2 241.19 9.46 1354 642927913 XP_008195445.1 1274 1.6e-137 PREDICTED: tRNA selenocysteine 1-associated protein 1 isoform X1 [Tribolium castaneum]>gi|270010282|gb|EFA06730.1| hypothetical protein TcasGA2_TC009661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q1RMJ7 508 4.5e-50 tRNA selenocysteine 1-associated protein 1 OS=Bos taurus GN=TRNAU1AP PE=2 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0118 FOG: RRM domain Cluster-8309.59874 BF_2 3.00 0.75 454 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59879 BF_2 99.60 4.48 1217 91083443 XP_970123.1 1233 8.4e-133 PREDICTED: tryptophan--tRNA ligase, mitochondrial [Tribolium castaneum] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 Q9UGM6 825 7.0e-87 Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens GN=WARS2 PE=1 SV=1 PF00579//PF04904 tRNA synthetases class I (W and Y)//NAB conserved region 1 (NCD1) GO:0045892//GO:0006418 negative regulation of transcription, DNA-templated//tRNA aminoacylation for protein translation GO:0004812//GO:0000166//GO:0005524 aminoacyl-tRNA ligase activity//nucleotide binding//ATP binding GO:0005634 nucleus KOG2713 Mitochondrial tryptophanyl-tRNA synthetase Cluster-8309.59881 BF_2 3.38 0.31 745 478260421 ENN80158.1 510 3.5e-49 hypothetical protein YQE_03421, partial [Dendroctonus ponderosae]>gi|546679917|gb|ERL90299.1| hypothetical protein D910_07650 [Dendroctonus ponderosae] -- -- -- -- -- K01867 WARS, trpS tryptophanyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K01867 Q9UGM6 344 2.6e-31 Tryptophan--tRNA ligase, mitochondrial OS=Homo sapiens GN=WARS2 PE=1 SV=1 PF00579//PF04904 tRNA synthetases class I (W and Y)//NAB conserved region 1 (NCD1) GO:0006418//GO:0045892 tRNA aminoacylation for protein translation//negative regulation of transcription, DNA-templated GO:0005524//GO:0000166//GO:0004812 ATP binding//nucleotide binding//aminoacyl-tRNA ligase activity GO:0005634 nucleus KOG2713 Mitochondrial tryptophanyl-tRNA synthetase Cluster-8309.59887 BF_2 7.73 1.87 460 642930742 XP_008196074.1 517 3.4e-50 PREDICTED: uncharacterized protein LOC655539 [Tribolium castaneum] -- -- -- -- -- K04919 KCNK9 potassium channel subfamily K member 9 http://www.genome.jp/dbget-bin/www_bget?ko:K04919 O35111 189 1.5e-13 Potassium channel subfamily K member 3 OS=Mus musculus GN=Kcnk3 PE=2 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.59891 BF_2 26.89 0.52 2434 270003866 EFA00314.1 1317 3.0e-142 hypothetical protein TcasGA2_TC003152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5PNP1 382 3.3e-35 Sorting nexin-14 OS=Danio rerio GN=snx14 PE=2 SV=3 PF00787 PX domain -- -- GO:0035091 phosphatidylinositol binding -- -- KOG2101 Intermediate filament-like protein, sorting nexins, and related proteins containing PX (PhoX) domain(s) Cluster-8309.59896 BF_2 33.14 0.61 2574 642910817 XP_008193421.1 1434 8.7e-156 PREDICTED: rab11 family-interacting protein 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K12484 RAB11FIP1_2_5 Rab11 family-interacting protein 1/2/5 http://www.genome.jp/dbget-bin/www_bget?ko:K12484 Q6WKZ4 309 1.0e-26 Rab11 family-interacting protein 1 OS=Homo sapiens GN=RAB11FIP1 PE=1 SV=3 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.59901 BF_2 9.00 0.59 921 307177802 EFN66784.1 143 1.6e-06 Transposable element Tc3 transposase, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59903 BF_2 105.27 0.50 9025 642914671 XP_008190309.1 831 2.6e-85 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 7.7e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF05631//PF00083 Major Facilitator Superfamily//Sugar-tranasporters, 12 TM//Sugar (and other) transporter GO:0055085//GO:0015689 transmembrane transport//molybdate ion transport GO:0022857//GO:0015098 transmembrane transporter activity//molybdate ion transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.59909 BF_2 7.00 0.37 1077 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.5991 BF_2 9.83 0.73 851 270016638 EFA13084.1 140 3.2e-06 hypothetical protein TcasGA2_TC011584 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892//PF06467 BED zinc finger//MYM-type Zinc finger with FCS sequence motif -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- -- -- Cluster-8309.59911 BF_2 103.48 3.22 1633 642913250 XP_008201456.1 1520 5.9e-166 PREDICTED: probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase [Tribolium castaneum] 585692231 XM_006821346.1 60 3.24318e-20 PREDICTED: Saccoglossus kowalevskii probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase-like (LOC102807371), mRNA K03849 ALG8 alpha-1,3-glucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K03849 Q9BVK2 1093 7.9e-118 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase OS=Homo sapiens GN=ALG8 PE=1 SV=2 PF03155 ALG6, ALG8 glycosyltransferase family -- -- GO:0016758 transferase activity, transferring hexosyl groups GO:0005789 endoplasmic reticulum membrane KOG2576 Glucosyltransferase - Alg8p Cluster-8309.59912 BF_2 54.56 8.15 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59921 BF_2 21.57 0.63 1726 752876725 XP_011255775.1 359 2.6e-31 PREDICTED: conserved oligomeric Golgi complex subunit 7-like, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.59944 BF_2 57.03 2.93 1100 642910923 XP_008193466.1 891 3.4e-93 PREDICTED: phospholipid scramblase 2-like isoform X1 [Tribolium castaneum]>gi|270014959|gb|EFA11407.1| hypothetical protein TcasGA2_TC013581 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3ZBG9 315 8.7e-28 Phospholipid scramblase 2 OS=Bos taurus GN=PLSCR2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0621 Phospholipid scramblase Cluster-8309.59945 BF_2 140.08 1.93 3325 642935230 XP_008199701.1 1350 6.2e-146 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum]>gi|642935232|ref|XP_008199702.1| PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- K10572 IPPK inositol-pentakisphosphate 2-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K10572 Q4JL91 355 6.1e-32 Inositol-pentakisphosphate 2-kinase OS=Danio rerio GN=ippk PE=1 SV=3 PF11857//PF06090 Domain of unknown function (DUF3377)//Inositol-pentakisphosphate 2-kinase -- -- GO:0035299//GO:0005524//GO:0004222 inositol pentakisphosphate 2-kinase activity//ATP binding//metalloendopeptidase activity -- -- KOG4749 Inositol polyphosphate kinase Cluster-8309.59953 BF_2 133.18 3.95 1698 642935459 XP_972294.2 602 1.7e-59 PREDICTED: uncharacterized protein LOC661011 isoform X2 [Tribolium castaneum] -- -- -- -- -- K11298 HMG2L1 high mobility group protein 2-like 1 http://www.genome.jp/dbget-bin/www_bget?ko:K11298 Q9UGU5 191 3.2e-13 HMG domain-containing protein 4 OS=Homo sapiens GN=HMGXB4 PE=1 SV=2 PF11770 GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.59954 BF_2 89.70 0.90 4458 91083873 XP_974306.1 619 4.8e-61 PREDICTED: uncharacterized protein LOC663153 [Tribolium castaneum]>gi|270007945|gb|EFA04393.1| hypothetical protein TcasGA2_TC014692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P70617 230 2.5e-17 Ninjurin-1 OS=Rattus norvegicus GN=Ninj1 PE=2 SV=1 PF04923//PF07469 Ninjurin//Domain of unknown function (DUF1518) GO:0007155//GO:0042246 cell adhesion//tissue regeneration -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.59959 BF_2 18.00 1.36 842 675366771 KFM59673.1 868 1.2e-90 Retrovirus-related Pol polyprotein from transposon 412, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- O92815 215 2.6e-16 Gag-Pol polyprotein OS=Walleye dermal sarcoma virus GN=gag-pol PE=1 SV=2 PF00665//PF13683 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.59960 BF_2 32.56 0.95 1721 675366330 KFM59232.1 1336 1.3e-144 Retrovirus-related Pol polyprotein from transposon 412, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P10394 665 3.6e-68 Retrovirus-related Pol polyprotein from transposon 412 OS=Drosophila melanogaster GN=POL PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.59962 BF_2 6.46 0.38 992 646697743 KDR09269.1 272 1.9e-21 hypothetical protein L798_00935, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02180 Bcl-2 homology region 4 GO:0042981 regulation of apoptotic process -- -- -- -- -- -- Cluster-8309.59967 BF_2 95.00 1.29 3375 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.59975 BF_2 20.75 0.32 2989 641659262 XP_008181029.1 668 6.7e-67 PREDICTED: zinc finger BED domain-containing protein 1-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- O96006 227 3.8e-17 Zinc finger BED domain-containing protein 1 OS=Homo sapiens GN=ZBED1 PE=1 SV=1 PF02892//PF14372 BED zinc finger//Domain of unknown function (DUF4413) -- -- GO:0003677 DNA binding -- -- KOG1121 Tam3-transposase (Ac family) Cluster-8309.59987 BF_2 47.47 1.03 2220 795015935 XP_011858320.1 1069 1.6e-113 PREDICTED: uncharacterized protein LOC105555888 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.59993 BF_2 6.00 0.60 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60000 BF_2 155.00 6.30 1316 91084467 XP_970521.1 377 1.6e-33 PREDICTED: uncharacterized protein LOC659096 [Tribolium castaneum]>gi|270008865|gb|EFA05313.1| hypothetical protein TcasGA2_TC015471 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60005 BF_2 5.00 0.31 963 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60013 BF_2 7.00 0.38 1058 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60014 BF_2 2.00 4.32 282 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60022 BF_2 15.97 0.42 1869 602676209 XP_007443574.1 184 5.6e-11 PREDICTED: zinc finger protein 850-like isoform X1 [Python bivittatus]>gi|602676211|ref|XP_007443575.1| PREDICTED: zinc finger protein 850-like isoform X2 [Python bivittatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8WTV1 171 7.4e-11 THAP domain-containing protein 3 OS=Homo sapiens GN=THAP3 PE=1 SV=1 PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.60026 BF_2 130.07 5.16 1342 642929029 XP_973509.2 335 1.2e-28 PREDICTED: SAYSvFN domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NPB0 138 3.6e-07 SAYSvFN domain-containing protein 1 OS=Homo sapiens GN=SAYSD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60029 BF_2 124.93 1.03 5379 642927353 XP_008195233.1 3614 0.0e+00 PREDICTED: A disintegrin and metalloproteinase with thrombospondin motifs 7-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8TE60 682 1.2e-69 A disintegrin and metalloproteinase with thrombospondin motifs 18 OS=Homo sapiens GN=ADAMTS18 PE=1 SV=3 PF15339//PF01421//PF00413//PF01562 Acrosome formation-associated factor//Reprolysin (M12B) family zinc metalloprotease//Matrixin//Reprolysin family propeptide GO:0006508//GO:0007342//GO:0060478//GO:0006897 proteolysis//fusion of sperm to egg plasma membrane//acrosomal vesicle exocytosis//endocytosis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012//GO:0005886 extracellular matrix//plasma membrane KOG3538 Disintegrin metalloproteinases with thrombospondin repeats Cluster-8309.60031 BF_2 19.81 0.32 2872 548545390 XP_005754095.1 216 1.7e-14 PREDICTED: zinc finger protein 93-like [Pundamilia nyererei] -- -- -- -- -- -- -- -- -- P52740 178 1.8e-11 Zinc finger protein 132 OS=Homo sapiens GN=ZNF132 PE=2 SV=2 PF07348//PF00096//PF16866//PF10426//PF07776//PF13465//PF07975//PF02892//PF01428 Syd protein (SUKH-2)//Zinc finger, C2H2 type//PHD-finger//Recombination-activating protein 1 zinc-finger domain//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//TFIIH C1-like domain//BED zinc finger//AN1-like Zinc finger GO:0006281 DNA repair GO:0005515//GO:0016788//GO:0003677//GO:0046872//GO:0016881//GO:0008270 protein binding//hydrolase activity, acting on ester bonds//DNA binding//metal ion binding//acid-amino acid ligase activity//zinc ion binding GO:0005634//GO:0009898 nucleus//cytoplasmic side of plasma membrane -- -- Cluster-8309.60033 BF_2 98.00 3.20 1570 642915387 XP_008190595.1 255 2.7e-19 PREDICTED: uncharacterized protein LOC100141615 [Tribolium castaneum]>gi|642915389|ref|XP_008190596.1| PREDICTED: uncharacterized protein LOC100141615 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01292 Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane -- -- Cluster-8309.60040 BF_2 169.61 1.41 5333 270002158 EEZ98605.1 1600 1.0e-174 hypothetical protein TcasGA2_TC001124 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q68DX3 288 5.7e-24 FERM and PDZ domain-containing protein 2 OS=Homo sapiens GN=FRMPD2 PE=1 SV=3 PF00595//PF13180//PF11427 PDZ domain (Also known as DHR or GLGF)//PDZ domain//Tc3 transposase -- -- GO:0005515//GO:0003677 protein binding//DNA binding -- -- -- -- Cluster-8309.60045 BF_2 7.70 0.33 1263 334849656 CCB84409.1 1496 2.8e-163 MHC class I antigen [Homo sapiens] 187783 M24097.1 1106 0 HUMMHCACA Human MHC class I HLA-C-alpha-2 chain and alternative mRNA, complete cds, clones 4 and 10 K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P30508 1496 1.1e-164 HLA class I histocompatibility antigen, Cw-12 alpha chain OS=Homo sapiens GN=HLA-C PE=1 SV=2 PF06623//PF05132//PF00129 MHC_I C-terminus//RNA polymerase III RPC4//Class I Histocompatibility antigen, domains alpha 1 and 2 GO:0006206//GO:0006955//GO:0006144//GO:0006351//GO:0006383//GO:0019882 pyrimidine nucleobase metabolic process//immune response//purine nucleobase metabolic process//transcription, DNA-templated//transcription from RNA polymerase III promoter//antigen processing and presentation GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005666//GO:0005730 DNA-directed RNA polymerase III complex//nucleolus -- -- Cluster-8309.60052 BF_2 5.00 1.27 451 675706491 XP_009007486.1 688 4.8e-70 PREDICTED: 40S ribosomal protein S15a [Callithrix jacchus] 71772414 NM_001030009.1 451 0 Homo sapiens ribosomal protein S15a (RPS15A), transcript variant 1, mRNA K02957 RP-S15Ae, RPS15A small subunit ribosomal protein S15Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02957 Q76I82 671 1.9e-69 40S ribosomal protein S15a OS=Bos taurus GN=RPS15A PE=2 SV=1 PF00410 Ribosomal protein S8 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1754 40S ribosomal protein S15/S22 Cluster-8309.60056 BF_2 1.00 2.39 278 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60062 BF_2 53.97 1.33 1988 270007333 EFA03781.1 773 3.0e-79 hypothetical protein TcasGA2_TC013892 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O76879 132 2.6e-06 Circadian clock-controlled protein OS=Drosophila melanogaster GN=anon-3B1.2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60076 BF_2 13.52 0.54 1339 829834934 XP_012634083.1 869 1.5e-90 PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834939|ref|XP_012634084.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834943|ref|XP_012634086.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834947|ref|XP_012634087.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834951|ref|XP_012634088.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834956|ref|XP_012634089.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834961|ref|XP_012634090.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834966|ref|XP_012634091.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834971|ref|XP_012634092.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834976|ref|XP_012634093.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834981|ref|XP_012634094.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834985|ref|XP_012634095.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834990|ref|XP_012634097.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus]>gi|829834999|ref|XP_012634099.1| PREDICTED: zinc finger MYM-type protein 2 isoform X1 [Microcebus murinus] -- -- -- -- -- -- -- -- -- Q96DM1 417 1.6e-39 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF01428//PF01609//PF07975 AN1-like Zinc finger//Transposase DDE domain//TFIIH C1-like domain GO:0006313//GO:0006281 transposition, DNA-mediated//DNA repair GO:0008270//GO:0003677//GO:0004803 zinc ion binding//DNA binding//transposase activity -- -- -- -- Cluster-8309.60080 BF_2 66.43 2.05 1645 642920283 XP_008192282.1 1907 7.9e-211 PREDICTED: DNA-directed RNA polymerase III subunit RPC3 [Tribolium castaneum]>gi|270006046|gb|EFA02494.1| hypothetical protein TcasGA2_TC008189 [Tribolium castaneum] -- -- -- -- -- K03023 RPC3, POLR3C DNA-directed RNA polymerase III subunit RPC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03023 Q9BUI4 901 1.5e-95 DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens GN=POLR3C PE=1 SV=1 PF05645 RNA polymerase III subunit RPC82 GO:0006351//GO:0006206//GO:0006144 transcription, DNA-templated//pyrimidine nucleobase metabolic process//purine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus KOG2587 RNA polymerase III (C) subunit Cluster-8309.60081 BF_2 5.00 0.58 647 817061123 XP_012252151.1 203 1.2e-13 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03193 Protein of unknown function, DUF258 -- -- GO:0005525//GO:0003924 GTP binding//GTPase activity -- -- -- -- Cluster-8309.60082 BF_2 8.00 1.66 489 4557695 NP_000213.1 402 7.7e-37 mast/stem cell growth factor receptor Kit isoform 1 precursor [Homo sapiens]>gi|125472|sp|P10721.1|KIT_HUMAN RecName: Full=Mast/stem cell growth factor receptor Kit; Short=SCFR; AltName: Full=Piebald trait protein; Short=PBT; AltName: Full=Proto-oncogene c-Kit; AltName: Full=Tyrosine-protein kinase Kit; AltName: Full=p145 c-kit; AltName: Full=v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; AltName: CD_antigen=CD117; Flags: Precursor>gi|34085|emb|CAA29548.1| unnamed protein product [Homo sapiens]>gi|825686|emb|CAA49159.1| mast/stem cell growth factor receptor [Homo sapiens]>gi|1817733|gb|AAC50968.1| KIT protein [Homo sapiens]>gi|119625865|gb|EAX05460.1| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, isoform CRA_a [Homo sapiens]>gi|119625866|gb|EAX05461.1| v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog, isoform CRA_a [Homo sapiens] 170014706 NG_007456.1 489 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P10721 402 3.2e-38 Mast/stem cell growth factor receptor Kit OS=Homo sapiens GN=KIT PE=1 SV=1 PF13895 Immunoglobulin domain GO:0007165//GO:0038093//GO:0035162//GO:0030217//GO:0019827//GO:0038162//GO:0097326//GO:0008284//GO:0002551//GO:0046777//GO:0010628//GO:0000187//GO:0006687//GO:0014068//GO:0010863//GO:0030318//GO:0042523//GO:0002371//GO:0001541//GO:0009314//GO:0030218//GO:0097324//GO:0032762//GO:0035234//GO:0030032//GO:0050910//GO:0048070//GO:0060374//GO:0038109//GO:0023014//GO:0002320//GO:0042511//GO:0043552//GO:0070662//GO:0008360//GO:0008584//GO:0097067//GO:0043303//GO:0043069//GO:0031532//GO:0002318//GO:0006954//GO:0002327//GO:0051091//GO:0035855//GO:0042517//GO:0048565//GO:0007286//GO:0007169 signal transduction//Fc receptor signaling pathway//embryonic hemopoiesis//T cell differentiation//stem cell population maintenance//erythropoietin-mediated signaling pathway//melanocyte adhesion//positive regulation of cell proliferation//mast cell chemotaxis//protein autophosphorylation//positive regulation of gene expression//activation of MAPK activity//glycosphingolipid metabolic process//positive regulation of phosphatidylinositol 3-kinase signaling//positive regulation of phospholipase C activity//melanocyte differentiation//positive regulation of tyrosine phosphorylation of Stat5 protein//dendritic cell cytokine production//ovarian follicle development//response to radiation//erythrocyte differentiation//melanocyte migration//mast cell cytokine production//ectopic germ cell programmed cell death//lamellipodium assembly//detection of mechanical stimulus involved in sensory perception of sound//regulation of developmental pigmentation//mast cell differentiation//Kit signaling pathway//signal transduction by protein phosphorylation//lymphoid progenitor cell differentiation//positive regulation of tyrosine phosphorylation of Stat1 protein//positive regulation of phosphatidylinositol 3-kinase activity//mast cell proliferation//regulation of cell shape//male gonad development//cellular response to thyroid hormone stimulus//mast cell degranulation//negative regulation of programmed cell death//actin cytoskeleton reorganization//myeloid progenitor cell differentiation//inflammatory response//immature B cell differentiation//positive regulation of sequence-specific DNA binding transcription factor activity//megakaryocyte development//positive regulation of tyrosine phosphorylation of Stat3 protein//digestive tract development//spermatid development//transmembrane receptor protein tyrosine kinase signaling pathway GO:0019955//GO:0002020//GO:0005020//GO:0005515//GO:0042803//GO:0005524//GO:0004716//GO:0046872 cytokine binding//protease binding//stem cell factor receptor activity//protein binding//protein homodimerization activity//ATP binding//receptor signaling protein tyrosine kinase activity//metal ion binding GO:0016021//GO:0005737//GO:0005634//GO:0009897//GO:0005615 integral component of membrane//cytoplasm//nucleus//external side of plasma membrane//extracellular space -- -- Cluster-8309.60088 BF_2 57.00 1.74 1656 -- -- -- -- -- 749791977 XR_850236.1 49 4.28592e-14 PREDICTED: Harpegnathos saltator uncharacterized LOC105189064 (LOC105189064), ncRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60096 BF_2 58.30 0.80 3340 642929775 XP_008195969.1 1222 4.3e-131 PREDICTED: uncharacterized protein LOC664468 isoform X2 [Tribolium castaneum] 642929774 XM_008197747.1 105 6.47048e-45 PREDICTED: Tribolium castaneum uncharacterized LOC664468 (LOC664468), transcript variant X2, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60100 BF_2 13.34 1.48 664 478254123 ENN74405.1 205 7.3e-14 hypothetical protein YQE_08990, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06083 Interleukin-17 GO:0006954//GO:0007165 inflammatory response//signal transduction GO:0005125 cytokine activity GO:0005576 extracellular region -- -- Cluster-8309.60106 BF_2 4.00 0.33 789 270016146 EFA12594.1 266 7.3e-21 hypothetical protein TcasGA2_TC001834 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60113 BF_2 94.98 0.79 5298 642922778 XP_008193321.1 2493 2.9e-278 PREDICTED: transmembrane and TPR repeat-containing protein 4 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 1418 5.3e-155 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13176//PF13414//PF13174//PF00515//PF13374//PF13181//PF02827 Tetratricopeptide repeat//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//cAMP-dependent protein kinase inhibitor GO:0006469//GO:0045859 negative regulation of protein kinase activity//regulation of protein kinase activity GO:0004862//GO:0005515 cAMP-dependent protein kinase inhibitor activity//protein binding GO:0005952 cAMP-dependent protein kinase complex KOG1124 FOG: TPR repeat Cluster-8309.60120 BF_2 46.18 0.46 4453 560124991 CDJ90379.1 550 4.8e-53 uncharacterized protein LOC100903664 [Haemonchus contortus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05970 PIF1-like helicase GO:0006281//GO:0000723 DNA repair//telomere maintenance GO:0003678 DNA helicase activity GO:0005657 replication fork -- -- Cluster-8309.60123 BF_2 52.70 1.03 2423 642934709 XP_008197779.1 945 4.1e-99 PREDICTED: condensin complex subunit 2 [Tribolium castaneum] -- -- -- -- -- K06676 BRRN1, BRN1, CAPH condensin complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K06676 O13067 318 8.7e-28 Condensin complex subunit 2 OS=Xenopus laevis GN=ncaph PE=1 SV=1 PF15427//PF05786 S100P-binding protein//Condensin complex subunit 2 GO:0007076 mitotic chromosome condensation GO:0048306 calcium-dependent protein binding GO:0000796 condensin complex KOG2328 Chromosome condensation complex Condensin, subunit H Cluster-8309.6013 BF_2 12.00 0.36 1695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60131 BF_2 1.00 1.56 296 4502981 NP_001852.1 324 5.1e-28 cytochrome c oxidase subunit 4 isoform 1, mitochondrial precursor [Homo sapiens]>gi|353681773|ref|NP_001238844.1| cytochrome c oxidase subunit 4 isoform 1, mitochondrial [Pan troglodytes]>gi|397500380|ref|XP_003820894.1| PREDICTED: cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [Pan paniscus]>gi|530423589|ref|XP_005255855.1| PREDICTED: cytochrome c oxidase subunit 4 isoform 1, mitochondrial isoform X1 [Homo sapiens]>gi|117086|sp|P13073.1|COX41_HUMAN RecName: Full=Cytochrome c oxidase subunit 4 isoform 1, mitochondrial; AltName: Full=Cytochrome c oxidase polypeptide IV; AltName: Full=Cytochrome c oxidase subunit IV isoform 1; Short=COX IV-1; Flags: Precursor>gi|180933|gb|AAA99312.1| cytochrome c oxidase subunit IV precursor [Homo sapiens]>gi|180935|gb|AAA52059.1| cytochrome c oxidase subunit IV (COX4) [Homo sapiens]>gi|517252|emb|CAA38573.1| cytochrome-c oxidase subunit IV [Homo sapiens]>gi|1913896|gb|AAB51058.1| cytochrome c oxidase subunit IV [Homo sapiens]>gi|2738492|gb|AAB94819.1| cytochrome c oxidase subunit IV precursor [Homo sapiens]>gi|4092857|gb|AAC99578.1| cytochrome c oxidase subunit IV precursor [Homo sapiens]>gi|14250514|gb|AAH08704.1| Cytochrome c oxidase subunit IV isoform 1 [Homo sapiens]>gi|18203795|gb|AAH21236.1| Cytochrome c oxidase subunit IV isoform 1 [Homo sapiens]>gi|54696512|gb|AAV38628.1| cytochrome c oxidase subunit IV isoform 1 [Homo sapiens]>gi|61357719|gb|AAX41434.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct]>gi|119615843|gb|EAW95437.1| cytochrome c oxidase subunit IV isoform 1, isoform CRA_b [Homo sapiens]>gi|119615844|gb|EAW95438.1| cytochrome c oxidase subunit IV isoform 1, isoform CRA_b [Homo sapiens]>gi|123992973|gb|ABM84088.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct]>gi|123999899|gb|ABM87458.1| cytochrome c oxidase subunit IV isoform 1 [synthetic construct]>gi|189053167|dbj|BAG34789.1| unnamed protein product [Homo sapiens]>gi|649099306|gb|AIC48546.1| COX4I1, partial [synthetic construct]>gi|225734|prf||1312293A cytochrome c oxidase IV 767989402 XM_011522871.1 296 3.43515e-152 PREDICTED: Homo sapiens cytochrome c oxidase subunit IV isoform 1 (COX4I1), transcript variant X1, mRNA K02263 COX4 cytochrome c oxidase subunit 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02263 P13073 324 2.1e-29 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial OS=Homo sapiens GN=COX4I1 PE=1 SV=1 PF02936 Cytochrome c oxidase subunit IV GO:0022904//GO:0006123//GO:0044281//GO:0007584//GO:0015992 respiratory electron transport chain//mitochondrial electron transport, cytochrome c to oxygen//small molecule metabolic process//response to nutrient//proton transport GO:0004129 cytochrome-c oxidase activity GO:0005634//GO:0005743//GO:0045277 nucleus//mitochondrial inner membrane//respiratory chain complex IV -- -- Cluster-8309.60136 BF_2 57.00 2.91 1106 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60137 BF_2 2.00 0.47 464 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60147 BF_2 20.00 0.94 1175 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60152 BF_2 5.00 0.47 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6017 BF_2 7.00 0.41 997 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60176 BF_2 62.81 0.99 2933 642935230 XP_008199701.1 743 1.3e-75 PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum]>gi|642935232|ref|XP_008199702.1| PREDICTED: inositol-pentakisphosphate 2-kinase isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q4JL91 222 1.4e-16 Inositol-pentakisphosphate 2-kinase OS=Danio rerio GN=ippk PE=1 SV=3 PF06090//PF11857 Inositol-pentakisphosphate 2-kinase//Domain of unknown function (DUF3377) -- -- GO:0035299//GO:0005524//GO:0004222 inositol pentakisphosphate 2-kinase activity//ATP binding//metalloendopeptidase activity -- -- KOG4749 Inositol polyphosphate kinase Cluster-8309.60178 BF_2 12.00 1.62 597 642938932 XP_970153.3 203 1.1e-13 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum]>gi|270016170|gb|EFA12618.1| hypothetical protein TcasGA2_TC010240 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 179 2.8e-12 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106//PF00608 short chain dehydrogenase//Adenoviral fibre protein (repeat/shaft region) GO:0019062//GO:0009405//GO:0008152//GO:0007155 virion attachment to host cell//pathogenesis//metabolic process//cell adhesion GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.60180 BF_2 9.00 4.22 374 91095123 XP_970890.1 367 6.7e-33 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270015569|gb|EFA12017.1| hypothetical protein TcasGA2_TC005026 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 217 6.8e-17 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF01912//PF00106//PF01073//PF01370//PF12242 eIF-6 family//short chain dehydrogenase//3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family//NAD(P)H binding domain of trans-2-enoyl-CoA reductase GO:0008207//GO:0008209//GO:0055114//GO:0006694//GO:0008210//GO:0042256//GO:0008152 C21-steroid hormone metabolic process//androgen metabolic process//oxidation-reduction process//steroid biosynthetic process//estrogen metabolic process//mature ribosome assembly//metabolic process GO:0043022//GO:0050662//GO:0003824//GO:0003854//GO:0016491//GO:0016616 ribosome binding//coenzyme binding//catalytic activity//3-beta-hydroxy-delta5-steroid dehydrogenase activity//oxidoreductase activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- -- -- Cluster-8309.60182 BF_2 320.11 4.58 3212 91085531 XP_972280.1 1546 1.1e-168 PREDICTED: beta-ureidopropionase [Tribolium castaneum]>gi|270009199|gb|EFA05647.1| hypothetical protein TcasGA2_TC015857 [Tribolium castaneum] -- -- -- -- -- K01431 UPB1 beta-ureidopropionase http://www.genome.jp/dbget-bin/www_bget?ko:K01431 Q8VC97 1256 2.0e-136 Beta-ureidopropionase OS=Mus musculus GN=Upb1 PE=2 SV=1 PF00795 Carbon-nitrogen hydrolase GO:0006807 nitrogen compound metabolic process GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds -- -- KOG2648 Diphthamide biosynthesis protein Cluster-8309.60194 BF_2 70.27 1.80 1922 546676004 ERL87099.1 1494 7.2e-163 hypothetical protein D910_04499 [Dendroctonus ponderosae] -- -- -- -- -- K15027 EIF2D translation initiation factor 2D http://www.genome.jp/dbget-bin/www_bget?ko:K15027 Q58CR3 698 5.9e-72 Eukaryotic translation initiation factor 2D OS=Bos taurus GN=EIF2D PE=2 SV=1 PF01253//PF01472//PF02201 Translation initiation factor SUI1//PUA domain//SWIB/MDM2 domain GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743//GO:0005515 RNA binding//translation initiation factor activity//protein binding GO:0005840 ribosome KOG2522 Filamentous baseplate protein Ligatin, contains PUA domain Cluster-8309.60195 BF_2 86.73 2.14 1980 546676004 ERL87099.1 1404 2.0e-152 hypothetical protein D910_04499 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q58CR3 625 1.8e-63 Eukaryotic translation initiation factor 2D OS=Bos taurus GN=EIF2D PE=2 SV=1 PF01253//PF02201//PF01472 Translation initiation factor SUI1//SWIB/MDM2 domain//PUA domain GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0005515//GO:0003723//GO:0003743 protein binding//RNA binding//translation initiation factor activity GO:0005840 ribosome KOG2522 Filamentous baseplate protein Ligatin, contains PUA domain Cluster-8309.60205 BF_2 19.36 0.38 2418 642919387 XP_008191852.1 1900 7.6e-210 PREDICTED: synaptotagmin-5 isoform X3 [Tribolium castaneum] 768449804 XM_011568704.1 71 3.71238e-26 PREDICTED: Plutella xylostella synaptotagmin-5-like (LOC105396697), partial mRNA -- -- -- -- Q9R0N8 502 4.0e-49 Synaptotagmin-6 OS=Mus musculus GN=Syt6 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.60207 BF_2 4.00 0.51 614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60212 BF_2 7.67 0.50 933 189236986 XP_001810629.1 285 5.4e-23 PREDICTED: general transcription factor 3C polypeptide 5 [Tribolium castaneum]>gi|270006625|gb|EFA03073.1| hypothetical protein TcasGA2_TC010945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y5Q8 129 2.7e-06 General transcription factor 3C polypeptide 5 OS=Homo sapiens GN=GTF3C5 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2473 RNA polymerase III transcription factor (TF)IIIC subunit Cluster-8309.60220 BF_2 75.91 0.55 6010 642911720 XP_971006.2 1110 7.6e-118 PREDICTED: polycomb group RING finger protein 3 [Tribolium castaneum] 642911719 XM_965913.3 273 4.75857e-138 PREDICTED: Tribolium castaneum polycomb group RING finger protein 3 (LOC659626), mRNA K11488 PCGF3 polycomb group RING finger protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K11488 Q2KJ29 802 1.6e-83 Polycomb group RING finger protein 3 OS=Bos taurus GN=PCGF3 PE=2 SV=1 PF11789//PF03271//PF14634//PF12678//PF06467//PF00097//PF16685//PF13639 Zinc-finger of the MIZ type in Nse subunit//EB1-like C-terminal motif//zinc-RING finger domain//RING-H2 zinc finger//MYM-type Zinc finger with FCS sequence motif//Zinc finger, C3HC4 type (RING finger)//zinc RING finger of MSL2//Ring finger domain -- -- GO:0061630//GO:0046872//GO:0005515//GO:0008270//GO:0008017 ubiquitin protein ligase activity//metal ion binding//protein binding//zinc ion binding//microtubule binding GO:0045298 tubulin complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.60222 BF_2 96.05 1.85 2461 642913398 XP_008200993.1 287 8.4e-23 PREDICTED: fruitless isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IN81 267 7.2e-22 Sex determination protein fruitless OS=Drosophila melanogaster GN=fru PE=1 SV=1 PF00651 BTB/POZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60223 BF_2 391.28 2.60 6582 642931365 XP_008196548.1 7127 0.0e+00 PREDICTED: kinesin-like protein unc-104 isoform X4 [Tribolium castaneum] 8248420 AF247761.1 302 3.94433e-154 AF247761 Drosophila melanogaster kinesin superfamily member DUnc104 mRNA, complete cds K10392 KIF1 kinesin family member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10392 Q17BU3 5818 0.0e+00 Kinesin-like protein unc-104 OS=Aedes aegypti GN=unc-104 PE=3 SV=1 PF07353//PF10390//PF05014//PF05171//PF00498//PF00225//PF00959 Uroplakin II//RNA polymerase II elongation factor ELL//Nucleoside 2-deoxyribosyltransferase//Haemin-degrading HemS.ChuX domain//FHA domain//Kinesin motor domain//Phage lysozyme GO:0009159//GO:0009253//GO:0007018//GO:0006826//GO:0005975//GO:0007017//GO:0061024//GO:0006368//GO:0016998//GO:0006206 deoxyribonucleoside monophosphate catabolic process//peptidoglycan catabolic process//microtubule-based movement//iron ion transport//carbohydrate metabolic process//microtubule-based process//membrane organization//transcription elongation from RNA polymerase II promoter//cell wall macromolecule catabolic process//pyrimidine nucleobase metabolic process GO:0050144//GO:0005524//GO:0005515//GO:0003777//GO:0003796//GO:0070694//GO:0008017 nucleoside deoxyribosyltransferase activity//ATP binding//protein binding//microtubule motor activity//lysozyme activity//deoxyribonucleoside 5'-monophosphate N-glycosidase activity//microtubule binding GO:0045298//GO:0005874//GO:0030176//GO:0008023 tubulin complex//microtubule//integral component of endoplasmic reticulum membrane//transcription elongation factor complex KOG0245 Kinesin-like protein Cluster-8309.60226 BF_2 15.39 0.42 1812 91087599 XP_972227.1 624 5.2e-62 PREDICTED: uncharacterized protein LOC660940 [Tribolium castaneum]>gi|270010702|gb|EFA07150.1| hypothetical protein TcasGA2_TC010144 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60231 BF_2 7.00 0.43 970 91085361 XP_971346.1 1066 1.5e-113 PREDICTED: zinc carboxypeptidase [Tribolium castaneum]>gi|270009301|gb|EFA05749.1| hypothetical protein TcasGA2_TC015782 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P42788 828 2.5e-87 Zinc carboxypeptidase (Fragment) OS=Simulium vittatum PE=2 SV=1 PF02244//PF05436//PF00246 Carboxypeptidase activation peptide//Mating factor alpha precursor N-terminus//Zinc carboxypeptidase GO:0007618//GO:0006508 mating//proteolysis GO:0008270//GO:0004180//GO:0004181 zinc ion binding//carboxypeptidase activity//metallocarboxypeptidase activity GO:0005576 extracellular region -- -- Cluster-8309.60238 BF_2 1.00 0.36 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60243 BF_2 15.48 0.31 2409 91095179 XP_971501.1 1041 3.0e-110 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43663 554 3.7e-55 Protein regulator of cytokinesis 1 OS=Homo sapiens GN=PRC1 PE=1 SV=2 PF03999 Microtubule associated protein (MAP65/ASE1 family) GO:0000910//GO:0000226 cytokinesis//microtubule cytoskeleton organization GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.60247 BF_2 33.60 0.65 2458 91095179 XP_971501.1 1008 2.1e-106 PREDICTED: protein regulator of cytokinesis 1 [Tribolium castaneum]>gi|270015868|gb|EFA12316.1| hypothetical protein TcasGA2_TC005107 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O43663 554 3.8e-55 Protein regulator of cytokinesis 1 OS=Homo sapiens GN=PRC1 PE=1 SV=2 PF03999 Microtubule associated protein (MAP65/ASE1 family) GO:0000910//GO:0000226 cytokinesis//microtubule cytoskeleton organization GO:0008017 microtubule binding GO:0045298 tubulin complex KOG4302 Microtubule-associated protein essential for anaphase spindle elongation Cluster-8309.60251 BF_2 1.00 1.13 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60253 BF_2 1.00 1.78 290 759081097 XP_011350402.1 157 1.2e-08 PREDICTED: uncharacterized protein LOC105286849 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60254 BF_2 17.84 1.26 878 861587820 KMQ82561.1 367 1.6e-32 transposable element tc3 transposase, partial [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404//PF04790 AsnC-type helix-turn-helix domain//Sarcoglycan complex subunit protein GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.60256 BF_2 8.35 0.73 764 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60257 BF_2 4.16 0.32 832 861608762 KMQ84872.1 309 8.0e-26 hypothetical protein RF55_16973 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04218//PF04790//PF13404 CENP-B N-terminal DNA-binding domain//Sarcoglycan complex subunit protein//AsnC-type helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003677 sequence-specific DNA binding//DNA binding GO:0016021//GO:0016012 integral component of membrane//sarcoglycan complex -- -- Cluster-8309.6026 BF_2 10.00 0.77 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60264 BF_2 80.76 0.43 8058 16903179 AAK61417.1 198 5.8e-12 transposase [Ceratitis rosa] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01585//PF01786 G-patch domain//Alternative oxidase GO:0055114//GO:0006118 oxidation-reduction process//obsolete electron transport GO:0009916//GO:0003676 alternative oxidase activity//nucleic acid binding -- -- -- -- Cluster-8309.60276 BF_2 47.15 1.00 2259 642915245 XP_008190539.1 1070 1.2e-113 PREDICTED: ZZ-type zinc finger-containing protein 3 [Tribolium castaneum]>gi|270003948|gb|EFA00396.1| hypothetical protein TcasGA2_TC003246 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IYH5 407 3.9e-38 ZZ-type zinc finger-containing protein 3 OS=Homo sapiens GN=ZZZ3 PE=1 SV=1 PF00569 Zinc finger, ZZ type -- -- GO:0008270//GO:0005488 zinc ion binding//binding -- -- -- -- Cluster-8309.60277 BF_2 12.00 0.35 1713 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60282 BF_2 50.92 1.34 1880 270005507 EFA01955.1 585 1.8e-57 hypothetical protein TcasGA2_TC007571 [Tribolium castaneum] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 P20432 513 1.6e-50 Glutathione S-transferase 1-1 OS=Drosophila melanogaster GN=GstD1 PE=1 SV=1 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60287 BF_2 6.00 0.78 607 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60288 BF_2 55.46 1.65 1693 746863244 XP_011062574.1 464 1.7e-43 PREDICTED: caspase-1-like [Acromyrmex echinatior] -- -- -- -- -- K04397 CASP7 caspase 7 http://www.genome.jp/dbget-bin/www_bget?ko:K04397 P89116 418 1.5e-39 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.60304 BF_2 30.92 1.60 1098 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60305 BF_2 82.97 0.62 5929 642937342 XP_008198796.1 1602 6.7e-175 PREDICTED: acid sphingomyelinase-like phosphodiesterase 3b [Tribolium castaneum] -- -- -- -- -- K01128 SMPDL3 sphingomyelin phosphodiesterase acid-like 3 http://www.genome.jp/dbget-bin/www_bget?ko:K01128 P58242 552 1.6e-54 Acid sphingomyelinase-like phosphodiesterase 3b OS=Mus musculus GN=Smpdl3b PE=1 SV=1 PF00119 ATP synthase A chain GO:0015992//GO:0015986 proton transport//ATP synthesis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.60306 BF_2 7.00 0.80 655 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60307 BF_2 11.00 0.31 1749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60312 BF_2 42.15 1.29 1652 546679672 ERL90099.1 1785 1.1e-196 hypothetical protein D910_07453 [Dendroctonus ponderosae] -- -- -- -- -- K12367 DOCK2 dedicator of cytokinesis protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12367 Q8C3J5 1015 8.9e-109 Dedicator of cytokinesis protein 2 OS=Mus musculus GN=Dock2 PE=1 SV=3 PF00018//PF14604 SH3 domain//Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60314 BF_2 14.29 0.59 1297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60315 BF_2 3.99 0.45 660 478263028 ENN81428.1 386 7.5e-35 hypothetical protein YQE_02121, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60317 BF_2 87.29 0.72 5360 270013679 EFA10127.1 1321 2.3e-142 hypothetical protein TcasGA2_TC012307 [Tribolium castaneum] -- -- -- -- -- K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 659 5.5e-67 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF00008//PF03028//PF01467 EGF-like domain//Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like GO:0007018//GO:0007017//GO:0009058 microtubule-based movement//microtubule-based process//biosynthetic process GO:0003824//GO:0005515//GO:0003777 catalytic activity//protein binding//microtubule motor activity GO:0030286//GO:0005874 dynein complex//microtubule KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.60333 BF_2 59.00 1.16 2424 270002290 EEZ98737.1 2444 6.3e-273 hypothetical protein TcasGA2_TC001292 [Tribolium castaneum] -- -- -- -- -- K03352 APC5 anaphase-promoting complex subunit 5 http://www.genome.jp/dbget-bin/www_bget?ko:K03352 Q9UJX4 838 4.4e-88 Anaphase-promoting complex subunit 5 OS=Homo sapiens GN=ANAPC5 PE=1 SV=2 PF07721//PF00515//PF13374//PF13181//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat -- -- GO:0042802//GO:0005515 identical protein binding//protein binding -- -- KOG4322 Anaphase-promoting complex (APC), subunit 5 Cluster-8309.60336 BF_2 4.00 0.34 779 -- -- -- -- -- 55832417 AY800246.1 118 8.66293e-53 Tribolium castaneum pangolin gene, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60338 BF_2 3.21 0.53 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60340 BF_2 2.00 1.33 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60359 BF_2 3.52 0.39 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60361 BF_2 1.00 0.50 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60363 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60367 BF_2 1.00 0.32 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60370 BF_2 6.99 0.38 1057 642920067 XP_008192192.1 545 4.4e-53 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- K14284 NXF, TAP, MEX67 nuclear RNA export factor http://www.genome.jp/dbget-bin/www_bget?ko:K14284 Q9UBU9 236 1.2e-18 Nuclear RNA export factor 1 OS=Homo sapiens GN=NXF1 PE=1 SV=1 PF03943 TAP C-terminal domain GO:0051028 mRNA transport -- -- GO:0005634 nucleus -- -- Cluster-8309.6038 BF_2 36.00 1.15 1597 821123351 XP_012384018.1 412 1.7e-37 PREDICTED: zinc finger protein 420-like [Dasypus novemcinctus] -- -- -- -- -- -- -- -- -- P18753 385 9.7e-36 Oocyte zinc finger protein XlCOF8.4 (Fragment) OS=Xenopus laevis PE=2 SV=1 PF00096//PF13465//PF00130//PF02892//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//BED zinc finger//C2H2-type zinc finger//zinc-finger C2H2-type GO:0035556 intracellular signal transduction GO:0046872//GO:0003677 metal ion binding//DNA binding -- -- -- -- Cluster-8309.60383 BF_2 7.00 1.57 473 -- -- -- -- -- 407894523 CP003872.1 371 0 Acidovorax sp. KKS102, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60386 BF_2 186.07 5.49 1704 91085721 XP_973270.1 1592 2.8e-174 PREDICTED: UPF0586 protein CG11596 [Tribolium castaneum]>gi|270010015|gb|EFA06463.1| hypothetical protein TcasGA2_TC009347 [Tribolium castaneum] 572265872 XM_006611000.1 68 1.20969e-24 PREDICTED: Apis dorsata UPF0586 protein C9orf41-like (LOC102671931), transcript variant X2, mRNA -- -- -- -- Q9I7X6 884 1.4e-93 Carnosine N-methyltransferase OS=Drosophila melanogaster GN=CG11596 PE=1 SV=1 PF08241 Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- KOG2798 Putative trehalase Cluster-8309.60392 BF_2 125.61 1.42 3985 270014457 EFA10905.1 2534 3.8e-283 hypothetical protein TcasGA2_TC001731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99315 820 8.8e-86 Transposon Ty3-G Gag-Pol polyprotein OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TY3B-G PE=1 SV=3 PF01176//PF01580//PF16588//PF00098 Translation initiation factor 1A / IF-1//FtsK/SpoIIIE family//C2H2 zinc-finger//Zinc knuckle GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003676//GO:0000166//GO:0008270//GO:0003743//GO:0003677//GO:0005524//GO:0003723 nucleic acid binding//nucleotide binding//zinc ion binding//translation initiation factor activity//DNA binding//ATP binding//RNA binding GO:0005840 ribosome -- -- Cluster-8309.60393 BF_2 1.00 0.32 418 270006314 EFA02762.1 464 4.3e-44 hypothetical protein TcasGA2_TC008495 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09575 180 1.5e-12 Uncharacterized protein K02A2.6 OS=Caenorhabditis elegans GN=K02A2.6 PE=3 SV=1 PF13683//PF00665 Integrase core domain//Integrase core domain GO:0015074 DNA integration -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.60395 BF_2 15.00 10.37 342 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60398 BF_2 7.91 0.38 1156 478256643 ENN76825.1 205 1.3e-13 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N3L3 145 4.7e-08 Beta-taxilin OS=Homo sapiens GN=TXLNB PE=1 SV=3 PF00548//PF09728 3C cysteine protease (picornain 3C)//Myosin-like coiled-coil protein GO:0006508 proteolysis GO:0019905//GO:0004197 syntaxin binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.60403 BF_2 8.00 0.41 1113 166919225 ABZ04010.1 605 5.1e-60 serine protease 2 [Costelytra zealandica] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P35036 523 6.7e-52 Trypsin-2 OS=Anopheles gambiae GN=TRYP2 PE=2 SV=2 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.60410 BF_2 3.00 0.44 570 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60423 BF_2 4.00 0.44 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60431 BF_2 31.67 1.09 1503 91088447 XP_968769.1 946 2.0e-99 PREDICTED: PI-PLC X domain-containing protein 3 isoform X1 [Tribolium castaneum]>gi|270012211|gb|EFA08659.1| hypothetical protein TcasGA2_TC006324 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58EK3 556 1.4e-55 PI-PLC X domain-containing protein 3 OS=Danio rerio GN=plcxd3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4306 Glycosylphosphatidylinositol-specific phospholipase C Cluster-8309.60432 BF_2 31.50 0.37 3833 642918821 XP_972786.2 1179 4.8e-126 PREDICTED: TNF receptor-associated factor 3 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 298 2.9e-25 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF01757//PF06009//PF02176 Acyltransferase family//Laminin Domain II//TRAF-type zinc finger GO:0007155 cell adhesion GO:0008270//GO:0016747 zinc ion binding//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.60433 BF_2 31.06 0.88 1767 546678692 ERL89260.1 1516 1.9e-165 hypothetical protein D910_06633, partial [Dendroctonus ponderosae] -- -- -- -- -- K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 Q9UIQ6 815 1.5e-85 Leucyl-cystinyl aminopeptidase OS=Homo sapiens GN=LNPEP PE=1 SV=3 PF01433 Peptidase family M1 -- -- GO:0008237//GO:0008270 metallopeptidase activity//zinc ion binding -- -- KOG1046 Puromycin-sensitive aminopeptidase and related aminopeptidases Cluster-8309.60436 BF_2 31.43 1.36 1252 270009426 EFA05874.1 312 5.4e-26 hypothetical protein TcasGA2_TC008683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60442 BF_2 8.22 0.37 1210 270007554 EFA04002.1 756 1.7e-77 hypothetical protein TcasGA2_TC014151 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BG19 536 2.3e-53 Transmembrane and TPR repeat-containing protein 4 OS=Mus musculus GN=Tmtc4 PE=2 SV=1 PF13414//PF13176//PF13371//PF13374//PF13181//PF00515 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1124 FOG: TPR repeat Cluster-8309.60444 BF_2 8.73 0.32 1434 546673028 ERL84714.1 1425 5.4e-155 hypothetical protein D910_02139 [Dendroctonus ponderosae] 826423471 XM_012671271.1 43 8.00683e-11 PREDICTED: Monomorium pharaonis putative inorganic phosphate cotransporter (LOC105831269), mRNA K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 O61369 716 3.6e-74 Putative inorganic phosphate cotransporter OS=Drosophila ananassae GN=Picot PE=3 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.60446 BF_2 1.00 0.46 376 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6045 BF_2 31.00 2.35 840 642929267 XP_008195763.1 591 1.6e-58 PREDICTED: uncharacterized protein LOC103313674 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.60457 BF_2 68.00 2.82 1296 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60459 BF_2 16.00 0.42 1865 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60460 BF_2 9.24 0.51 1052 861624759 KMQ88359.1 1144 1.5e-122 gag-pol polyprotein [Lasius niger] -- -- -- -- -- -- -- -- -- P0CT41 432 2.3e-41 Transposon Tf2-12 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-12 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0017 FOG: Transposon-encoded proteins with TYA, reverse transcriptase, integrase domains in various combinations Cluster-8309.60466 BF_2 15.56 1.90 630 646702743 KDR11794.1 147 3.7e-07 hypothetical protein L798_14173 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60467 BF_2 22.02 0.78 1467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60471 BF_2 60.71 0.95 2965 478253883 ENN74175.1 2319 2.4e-258 hypothetical protein YQE_09148, partial [Dendroctonus ponderosae] 887513412 KP641329.1 728 0 Leptinotarsa decemlineata putative aryl hydrocarbon receptor Dys mRNA, complete cds -- -- -- -- Q8IUM7 514 2.0e-50 Neuronal PAS domain-containing protein 4 OS=Homo sapiens GN=NPAS4 PE=1 SV=1 PF00010//PF08447//PF00989 Helix-loop-helix DNA-binding domain//PAS fold//PAS fold GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.60483 BF_2 3.00 0.65 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6049 BF_2 80.47 0.97 3775 642925496 XP_008194575.1 1114 1.6e-118 PREDICTED: serendipity locus protein alpha-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O77201 188 1.6e-12 Serendipity locus protein alpha OS=Drosophila virilis GN=Sry-alpha PE=3 SV=1 PF05482//PF02969//PF02637 Serendipity locus alpha protein (SRY-A)//TATA box binding protein associated factor (TAF)//GatB domain GO:0007349//GO:0006352 cellularization//DNA-templated transcription, initiation GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor GO:0016020//GO:0005634//GO:0005737 membrane//nucleus//cytoplasm KOG2549 Transcription initiation factor TFIID, subunit TAF6 (also component of histone acetyltransferase SAGA) Cluster-8309.60490 BF_2 52.97 0.95 2631 642918886 XP_008191628.1 1145 2.9e-122 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q09225 380 6.1e-35 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF11894//PF01757//PF15281 Nuclear pore complex scaffold, nucleoporins 186/192/205//Acyltransferase family//Consortin C-terminus GO:0042998 positive regulation of Golgi to plasma membrane protein transport GO:0016747//GO:0071253 transferase activity, transferring acyl groups other than amino-acyl groups//connexin binding GO:0005802//GO:0005643 trans-Golgi network//nuclear pore -- -- Cluster-8309.60494 BF_2 7.12 0.35 1131 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60495 BF_2 12.00 0.67 1038 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60497 BF_2 14.36 0.39 1817 478252789 ENN73182.1 1064 4.9e-113 hypothetical protein YQE_10236, partial [Dendroctonus ponderosae]>gi|546682445|gb|ERL92378.1| hypothetical protein D910_09692 [Dendroctonus ponderosae] -- -- -- -- -- K15108 SLC25A19, DNC, TPC1 solute carrier family 25 (mitochondrial thiamine pyrophosphate transporter), member 19 http://www.genome.jp/dbget-bin/www_bget?ko:K15108 Q5IS35 624 2.1e-63 Mitochondrial thiamine pyrophosphate carrier OS=Macaca fascicularis GN=SLC25A19 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0752 Mitochondrial solute carrier protein Cluster-8309.60498 BF_2 3.00 0.50 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60511 BF_2 17.00 0.54 1608 642932870 XP_008197019.1 211 3.6e-14 PREDICTED: integumentary mucin A.1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05366//PF00095//PF04661 Sarcolipin//WAP-type (Whey Acidic Protein) 'four-disulfide core'//Poxvirus I3 ssDNA-binding protein -- -- GO:0003697//GO:0030234//GO:0030414 single-stranded DNA binding//enzyme regulator activity//peptidase inhibitor activity GO:0016020//GO:0005576 membrane//extracellular region -- -- Cluster-8309.60516 BF_2 8.00 74.88 235 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60540 BF_2 16.58 0.40 2028 642936321 XP_008198395.1 641 6.2e-64 PREDICTED: equilibrative nucleoside transporter 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BZD2 241 6.1e-19 Equilibrative nucleoside transporter 3 OS=Homo sapiens GN=SLC29A3 PE=1 SV=3 PF01733//PF07690 Nucleoside transporter//Major Facilitator Superfamily GO:0015858//GO:0055085//GO:0006810 nucleoside transport//transmembrane transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.60542 BF_2 3.00 0.70 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60543 BF_2 28.43 0.89 1627 642915433 XP_008190613.1 575 2.2e-56 PREDICTED: uncharacterized protein LOC663674 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13302//PF13673//PF08445//PF13508//PF00583 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) domain//FR47-like protein//Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family GO:0042967 acyl-carrier-protein biosynthetic process GO:0016747//GO:0008080 transferase activity, transferring acyl groups other than amino-acyl groups//N-acetyltransferase activity -- -- -- -- Cluster-8309.60547 BF_2 65.14 1.58 2013 478250007 ENN70513.1 662 2.3e-66 hypothetical protein YQE_12689, partial [Dendroctonus ponderosae] -- -- -- -- -- K00940 ndk, NME nucleoside-diphosphate kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00940 Q6DI51 444 1.8e-42 Nucleoside diphosphate kinase 6 OS=Danio rerio GN=nme6 PE=2 SV=1 PF00334 Nucleoside diphosphate kinase GO:0006165//GO:0006206//GO:0006241//GO:0006183//GO:0006228//GO:0006144 nucleoside diphosphate phosphorylation//pyrimidine nucleobase metabolic process//CTP biosynthetic process//GTP biosynthetic process//UTP biosynthetic process//purine nucleobase metabolic process GO:0004550 nucleoside diphosphate kinase activity -- -- KOG0888 Nucleoside diphosphate kinase Cluster-8309.60548 BF_2 2.00 0.88 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60556 BF_2 13.40 0.82 968 189239732 XP_968903.2 377 1.2e-33 PREDICTED: vitellogenin receptor [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P98163 145 4.0e-08 Putative vitellogenin receptor OS=Drosophila melanogaster GN=yl PE=1 SV=2 PF00008 EGF-like domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60567 BF_2 24.90 0.39 2973 642939748 XP_008193089.1 296 9.2e-24 PREDICTED: uncharacterized protein LOC103312938 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00049//PF03488 Insulin/IGF/Relaxin family//Nematode insulin-related peptide beta type GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.60568 BF_2 2.50 0.36 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60570 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60572 BF_2 32.00 1.31 1307 2804262 BAA24442.1 693 3.7e-70 cysteine proteinase [Sitophilus zeamais] -- -- -- -- -- K01371 CTSK cathepsin K http://www.genome.jp/dbget-bin/www_bget?ko:K01371 P25784 671 5.4e-69 Digestive cysteine proteinase 3 OS=Homarus americanus GN=LCP3 PE=2 SV=1 PF00112//PF03051 Papain family cysteine protease//Peptidase C1-like family GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.60575 BF_2 1.00 2.73 273 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60587 BF_2 81.03 1.51 2538 91082451 XP_971337.1 637 2.3e-63 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [Tribolium castaneum]>gi|270007152|gb|EFA03600.1| hypothetical protein TcasGA2_TC013687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9TV66 410 1.9e-38 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 OS=Oryctolagus cuniculus GN=HCN4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60589 BF_2 3.00 0.43 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6059 BF_2 6.91 2.87 386 91078218 XP_969246.1 393 6.7e-36 PREDICTED: ubiquitin-like protein 5 [Tribolium castaneum]>gi|270002984|gb|EEZ99431.1| hypothetical protein TcasGA2_TC030562 [Tribolium castaneum] 815820526 XM_012376058.1 88 1.95132e-36 PREDICTED: Linepithema humile ubiquitin-like protein 5 (LOC105677441), mRNA K13113 UBL5, HUB1 ubiquitin-like protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K13113 Q791B0 357 4.1e-33 Ubiquitin-like protein 5 OS=Psammomys obesus GN=UBL5 PE=3 SV=1 PF00240//PF14560 Ubiquitin family//Ubiquitin-like domain -- -- GO:0005515 protein binding -- -- KOG3493 Ubiquitin-like protein Cluster-8309.60591 BF_2 32.07 0.32 4466 662195961 XP_008470989.1 905 3.3e-94 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60594 BF_2 107.42 4.66 1251 189233697 XP_966459.2 900 3.5e-94 PREDICTED: uncharacterized protein C17orf59 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D6W8 247 7.6e-20 Uncharacterized protein C17orf59 homolog OS=Mus musculus PE=1 SV=1 PF00413 Matrixin GO:0006508 proteolysis GO:0008270//GO:0004222 zinc ion binding//metalloendopeptidase activity GO:0031012 extracellular matrix KOG4514 Uncharacterized conserved protein Cluster-8309.606 BF_2 3.00 4.38 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60603 BF_2 1.00 0.35 404 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60604 BF_2 24.51 0.39 2894 642927511 XP_008195299.1 3251 0.0e+00 PREDICTED: lutropin-choriogonadotropic hormone receptor-like [Tribolium castaneum] -- -- -- -- -- K04248 LHCGR luteinizing hormone/choriogonadotropin receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04248 Q90674 1117 2.3e-120 Lutropin-choriogonadotropic hormone receptor OS=Gallus gallus GN=LHCGR PE=2 SV=2 PF00001//PF13855 7 transmembrane receptor (rhodopsin family)//Leucine rich repeat GO:0007186 G-protein coupled receptor signaling pathway GO:0005515//GO:0004930 protein binding//G-protein coupled receptor activity GO:0016021 integral component of membrane KOG2087 Glycoprotein hormone receptor Cluster-8309.60607 BF_2 11.92 0.54 1219 332374428 AEE62355.1 765 1.6e-78 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14530 RPP40 ribonucleases P/MRP protein subunit RPP40 http://www.genome.jp/dbget-bin/www_bget?ko:K14530 Q5BK64 292 4.5e-25 Ribonuclease P protein subunit p40 OS=Rattus norvegicus GN=Rpp40 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60612 BF_2 98.89 3.93 1340 642914590 XP_008190277.1 281 2.3e-22 PREDICTED: venom prothrombin activator trocarin-D-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q05589 136 6.1e-07 Urokinase-type plasminogen activator OS=Bos taurus GN=PLAU PE=2 SV=1 PF15220//PF00089 Hypoxia-inducible lipid droplet-associated//Trypsin GO:0001819//GO:0010884//GO:0006508//GO:0008284 positive regulation of cytokine production//positive regulation of lipid storage//proteolysis//positive regulation of cell proliferation GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.60619 BF_2 3.00 5.88 286 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60629 BF_2 77.94 1.00 3532 91093355 XP_969078.1 2088 1.8e-231 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IWG1 594 1.2e-59 WD repeat-containing protein 63 OS=Homo sapiens GN=WDR63 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG1587 Cytoplasmic dynein intermediate chain Cluster-8309.60638 BF_2 8.00 0.46 1012 675366330 KFM59232.1 337 5.5e-29 Retrovirus-related Pol polyprotein from transposon 412, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00665 Integrase core domain GO:0015074 DNA integration -- -- -- -- -- -- Cluster-8309.6064 BF_2 20.00 0.46 2103 642937652 XP_966876.3 509 1.3e-48 PREDICTED: zinc finger protein 57-like [Tribolium castaneum]>gi|270000795|gb|EEZ97242.1| hypothetical protein TcasGA2_TC011040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N1W2 348 2.5e-31 Zinc finger protein 710 OS=Homo sapiens GN=ZNF710 PE=2 SV=2 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.60640 BF_2 29.00 0.42 3172 817061123 XP_012252151.1 440 2.0e-40 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00580//PF00164//PF00437//PF00004 UvrD/REP helicase N-terminal domain//Ribosomal protein S12/S23//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0042254//GO:0006412//GO:0006810 ribosome biogenesis//translation//transport GO:0003735//GO:0005524 structural constituent of ribosome//ATP binding GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-8309.60642 BF_2 76.06 1.46 2468 642912489 XP_008200886.1 1862 2.0e-205 PREDICTED: Fanconi anemia group I protein homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NVI1 283 1.0e-23 Fanconi anemia group I protein OS=Homo sapiens GN=FANCI PE=1 SV=4 PF04557//PF00042//PF01294 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2//Globin//Ribosomal protein L13e GO:0042254//GO:0006425//GO:0006412 ribosome biogenesis//glutaminyl-tRNA aminoacylation//translation GO:0020037//GO:0003735//GO:0000166//GO:0004819//GO:0005524//GO:0019825 heme binding//structural constituent of ribosome//nucleotide binding//glutamine-tRNA ligase activity//ATP binding//oxygen binding GO:0005737//GO:0005840//GO:0005622 cytoplasm//ribosome//intracellular KOG4553 Uncharacterized conserved protein Cluster-8309.60644 BF_2 57.15 1.90 1545 642925935 XP_008194702.1 315 3.0e-26 PREDICTED: uncharacterized protein LOC103313383 [Tribolium castaneum]>gi|270008587|gb|EFA05035.1| hypothetical protein TcasGA2_TC015123 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60646 BF_2 11.75 0.34 1751 642937544 XP_008199089.1 962 3.2e-101 PREDICTED: major facilitator superfamily domain-containing protein 9-like isoform X2 [Tribolium castaneum]>gi|270001229|gb|EEZ97676.1| hypothetical protein TcasGA2_TC016221 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C0T7 437 9.9e-42 Major facilitator superfamily domain-containing protein 9 OS=Mus musculus GN=Mfsd9 PE=2 SV=1 PF05121//PF07690 Gas vesicle protein K//Major Facilitator Superfamily GO:0031412//GO:0055085 gas vesicle organization//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.60649 BF_2 34.44 0.48 3259 260781332 XP_002585771.1 633 8.4e-63 hypothetical protein BRAFLDRAFT_257357 [Branchiostoma floridae]>gi|229270812|gb|EEN41782.1| hypothetical protein BRAFLDRAFT_257357, partial [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- A6NN14 429 1.6e-40 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF16622//PF00096//PF13465 zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.60652 BF_2 18.00 0.50 1784 189240189 XP_975214.2 379 1.3e-33 PREDICTED: ABC transporter G family member 14 isoform X2 [Tribolium castaneum]>gi|270011649|gb|EFA08097.1| hypothetical protein TcasGA2_TC005701 [Tribolium castaneum] 642932113 XM_970121.3 139 4.3085e-64 PREDICTED: Tribolium castaneum ABC transporter G family member 14 (LOC664105), transcript variant X2, mRNA -- -- -- -- Q84TH5 130 4.0e-06 ABC transporter G family member 25 OS=Arabidopsis thaliana GN=ABCG25 PE=2 SV=1 PF01061//PF15202//PF02932//PF02749 ABC-2 type transporter//Adipogenin//Neurotransmitter-gated ion-channel transmembrane region//Quinolinate phosphoribosyl transferase, N-terminal domain GO:0006811//GO:0006200//GO:0045444 ion transport//obsolete ATP catabolic process//fat cell differentiation GO:0016763//GO:0016887//GO:0005524 transferase activity, transferring pentosyl groups//ATPase activity//ATP binding GO:0016020 membrane -- -- Cluster-8309.60654 BF_2 4.00 0.47 641 -- -- -- -- -- 462296791 APGK01052246.1 34 3.49978e-06 Dendroctonus ponderosae Seq01052256, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60655 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6067 BF_2 2.00 0.36 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60674 BF_2 14.84 0.58 1356 642913139 XP_008201409.1 1195 2.4e-128 PREDICTED: lachesin-like [Tribolium castaneum] 642913138 XM_008203187.1 74 4.42324e-28 PREDICTED: Tribolium castaneum lachesin-like (LOC663748), mRNA -- -- -- -- Q24372 337 3.0e-30 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6068 BF_2 3.00 2.02 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60681 BF_2 10.00 0.57 1025 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60683 BF_2 21.39 2.45 653 642934526 XP_008197699.1 561 3.8e-55 PREDICTED: platelet-derived growth factor receptor alpha isoform X2 [Tribolium castaneum] -- -- -- -- -- K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 370 2.2e-34 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 PF07714//PF02319//PF00069 Protein tyrosine kinase//E2F/DP family winged-helix DNA-binding domain//Protein kinase domain GO:0006355//GO:0006468 regulation of transcription, DNA-templated//protein phosphorylation GO:0005524//GO:0003700//GO:0004672 ATP binding//transcription factor activity, sequence-specific DNA binding//protein kinase activity GO:0005667 transcription factor complex KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.60685 BF_2 2.00 0.70 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60686 BF_2 94.00 2.18 2091 123227460 CAM27169.1 257 2.1e-19 novel KRAB box and zinc finger, C2H2 type domain containing protein [Mus musculus] 564252665 XM_006265293.1 115 1.11195e-50 PREDICTED: Alligator mississippiensis Sp5 transcription factor (SP5), mRNA K09199 SP9 transcription factor Sp9 http://www.genome.jp/dbget-bin/www_bget?ko:K09199 Q8VI67 577 6.9e-58 Transcription factor Sp7 OS=Mus musculus GN=Sp7 PE=1 SV=1 PF13912//PF13465//PF00096//PF15761 C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type//Immortalisation up-regulated protein -- -- GO:0046872 metal ion binding GO:0005634 nucleus -- -- Cluster-8309.60691 BF_2 40.91 1.03 1943 91079957 XP_969398.1 651 4.1e-65 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I3LM39 158 2.5e-09 Cyclic GMP-AMP synthase OS=Sus scrofa GN=MB21D1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60694 BF_2 24.09 0.89 1417 91079957 XP_969398.1 592 2.1e-58 PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|642918429|ref|XP_008191469.1| PREDICTED: cyclic GMP-AMP synthase [Tribolium castaneum]>gi|270004601|gb|EFA01049.1| hypothetical protein TcasGA2_TC003965 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- I3LM39 158 1.8e-09 Cyclic GMP-AMP synthase OS=Sus scrofa GN=MB21D1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60711 BF_2 8.00 0.52 929 -- -- -- -- -- 761231856 KM881642.1 929 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C382 390 1.5e-36 Maturase K OS=Oryza sativa subsp. indica GN=matK PE=3 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60713 BF_2 7.53 0.32 1271 642917872 XP_969181.2 297 3.0e-24 PREDICTED: SET and MYND domain-containing protein 4-like [Tribolium castaneum]>gi|270004498|gb|EFA00946.1| hypothetical protein TcasGA2_TC003856 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H7B4 153 6.2e-09 Histone-lysine N-methyltransferase SMYD3 OS=Homo sapiens GN=SMYD3 PE=1 SV=4 PF00856 SET domain -- -- GO:0005515 protein binding -- -- KOG2084 Predicted histone tail methylase containing SET domain Cluster-8309.60716 BF_2 118.48 4.01 1522 642915148 XP_008190494.1 545 6.3e-53 PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915150|ref|XP_008190495.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915152|ref|XP_008190496.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum]>gi|642915154|ref|XP_008190497.1| PREDICTED: uncharacterized protein LOC103312207 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60718 BF_2 2.00 0.45 471 801399331 XP_012060168.1 333 7.4e-29 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Atta cephalotes] 801402375 XM_012205975.1 184 1.04213e-89 PREDICTED: Atta cephalotes histone-lysine N-methyltransferase SETMAR-like (LOC105624618), mRNA -- -- -- -- Q53H47 175 6.4e-12 Histone-lysine N-methyltransferase SETMAR OS=Homo sapiens GN=SETMAR PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60720 BF_2 1.00 0.31 422 5031571 NP_005713.1 721 6.8e-74 actin-related protein 2 isoform b [Homo sapiens]>gi|22122825|ref|NP_666355.1| actin-related protein 2 [Mus musculus]>gi|156121073|ref|NP_001095683.1| actin-related protein 2 [Bos taurus]>gi|197251934|ref|NP_001127826.1| actin-related protein 2 [Sus scrofa]>gi|388454380|ref|NP_001253869.1| actin-related protein 2 [Macaca mulatta]>gi|57093381|ref|XP_538516.1| PREDICTED: actin-related protein 2 isoform 1 [Canis lupus familiaris]>gi|194220672|ref|XP_001494439.2| PREDICTED: actin-related protein 2 isoform 1 [Equus caballus]>gi|296223698|ref|XP_002757735.1| PREDICTED: actin-related protein 2 isoform X2 [Callithrix jacchus]>gi|301764717|ref|XP_002917780.1| PREDICTED: actin-related protein 2 [Ailuropoda melanoleuca]>gi|332226660|ref|XP_003262508.1| PREDICTED: actin-related protein 2 isoform X2 [Nomascus leucogenys]>gi|344283862|ref|XP_003413690.1| PREDICTED: actin-related protein 2 [Loxodonta africana]>gi|397521747|ref|XP_003830949.1| PREDICTED: actin-related protein 2 isoform X2 [Pan paniscus]>gi|402891079|ref|XP_003908787.1| PREDICTED: actin-related protein 2 isoform X2 [Papio anubis]>gi|410954922|ref|XP_003984108.1| PREDICTED: actin-related protein 2 isoform X2 [Felis catus]>gi|466062546|ref|XP_004280669.1| PREDICTED: actin-related protein 2 [Orcinus orca]>gi|472355797|ref|XP_004397545.1| PREDICTED: actin-related protein 2 isoform X2 [Odobenus rosmarus divergens]>gi|478522938|ref|XP_004435673.1| PREDICTED: actin-related protein 2 isoform 2 [Ceratotherium simum simum]>gi|488562618|ref|XP_004471025.1| PREDICTED: actin-related protein 2 isoform X2 [Dasypus novemcinctus]>gi|507552679|ref|XP_004660134.1| PREDICTED: actin-related protein 2 isoform X2 [Jaculus jaculus]>gi|507679324|ref|XP_004710229.1| PREDICTED: actin-related protein 2 isoform X2 [Echinops telfairi]>gi|507973777|ref|XP_004691516.1| PREDICTED: actin-related protein 2 [Condylura cristata]>gi|511835041|ref|XP_004742135.1| PREDICTED: actin-related protein 2 [Mustela putorius furo]>gi|512975889|ref|XP_004850016.1| PREDICTED: actin-related protein 2 [Heterocephalus glaber]>gi|514456556|ref|XP_005002696.1| PREDICTED: actin-related protein 2 isoform X2 [Cavia porcellus]>gi|532047438|ref|XP_005366505.1| PREDICTED: actin-related protein 2 isoform X2 [Microtus ochrogaster]>gi|532047440|ref|XP_005366506.1| PREDICTED: actin-related protein 2 isoform X3 [Microtus ochrogaster]>gi|532072635|ref|XP_005322132.1| PREDICTED: actin-related protein 2 isoform X2 [Ictidomys tridecemlineatus]>gi|533142227|ref|XP_005385748.1| PREDICTED: actin-related protein 2 isoform X2 [Chinchilla lanigera]>gi|544480960|ref|XP_005575787.1| PREDICTED: actin-related protein 2 isoform X2 [Macaca fascicularis]>gi|556735796|ref|XP_005963504.1| PREDICTED: actin-related protein 2 isoform X2 [Pantholops hodgsonii]>gi|558101623|ref|XP_006083334.1| PREDICTED: actin-related protein 2 isoform X2 [Myotis lucifugus]>gi|560958232|ref|XP_006201579.1| PREDICTED: actin-related protein 2 isoform X1 [Vicugna pacos]>gi|562880994|ref|XP_006168105.1| PREDICTED: actin-related protein 2-like isoform X2 [Tupaia chinensis]>gi|584040005|ref|XP_006778594.1| PREDICTED: actin-related protein 2 isoform X2 [Myotis davidii]>gi|585641643|ref|XP_006881031.1| PREDICTED: actin-related protein 2 isoform X2 [Elephantulus edwardii]>gi|586464772|ref|XP_006863013.1| PREDICTED: actin-related protein 2 isoform X1 [Chrysochloris asiatica]>gi|586549063|ref|XP_006909605.1| PREDICTED: actin-related protein 2 [Pteropus alecto]>gi|589924009|ref|XP_006974885.1| PREDICTED: actin-related protein 2 isoform X2 [Peromyscus maniculatus bairdii]>gi|591296504|ref|XP_007075405.1| PREDICTED: actin-related protein 2 isoform X2 [Panthera tigris altaica]>gi|593738748|ref|XP_007124951.1| PREDICTED: actin-related protein 2 [Physeter catodon]>gi|594058873|ref|XP_006053590.1| PREDICTED: actin-related protein 2 isoform X2 [Bubalus bubalis]>gi|594684587|ref|XP_007189816.1| PREDICTED: actin-related protein 2 isoform X2 [Balaenoptera acutorostrata scammoni]>gi|602707793|ref|XP_007464164.1| PREDICTED: actin-related protein 2 isoform X1 [Lipotes vexillifer]>gi|611982426|ref|XP_007476801.1| PREDICTED: actin-related protein 2 isoform X2 [Monodelphis domestica]>gi|617558745|ref|XP_007539667.1| PREDICTED: actin-related protein 2 isoform X2 [Erinaceus europaeus]>gi|625280923|ref|XP_007632127.1| PREDICTED: actin-related protein 2 isoform X2 [Cricetulus griseus]>gi|635080331|ref|XP_007968622.1| PREDICTED: actin-related protein 2 [Chlorocebus sabaeus]>gi|640809030|ref|XP_008061065.1| PREDICTED: actin-related protein 2 isoform X2 [Tarsius syrichta]>gi|641713032|ref|XP_008145759.1| PREDICTED: actin-related protein 2 isoform X2 [Eptesicus fuscus]>gi|655606658|ref|XP_008252549.1| PREDICTED: actin-related protein 2 isoform X2 [Oryctolagus cuniculus]>gi|667310439|ref|XP_008584404.1| PREDICTED: actin-related protein 2 isoform X2 [Galeopterus variegatus]>gi|674031591|ref|XP_008850714.1| PREDICTED: actin-related protein 2 isoform X2 [Nannospalax galili]>gi|724959946|ref|XP_010354125.1| PREDICTED: actin-related protein 2 isoform X2 [Rhinopithecus roxellana]>gi|725555610|ref|XP_010331832.1| PREDICTED: actin-related protein 2 isoform X2 [Saimiri boliviensis boliviensis]>gi|731278260|ref|XP_010608032.1| PREDICTED: actin-related protein 2 [Fukomys damarensis]>gi|744564047|ref|XP_010978221.1| PREDICTED: actin-related protein 2 isoform X2 [Camelus dromedarius]>gi|759183346|ref|XP_011380154.1| PREDICTED: actin-related protein 2 [Pteropus vampyrus]>gi|795162614|ref|XP_011840897.1| PREDICTED: actin-related protein 2 isoform X2 [Mandrillus leucophaeus]>gi|795491608|ref|XP_011895012.1| PREDICTED: actin-related protein 2 isoform X2 [Cercocebus atys]>gi|795510632|ref|XP_011711736.1| PREDICTED: actin-related protein 2 isoform X2 [Macaca nemestrina]>gi|803242199|ref|XP_011981190.1| PREDICTED: actin-related protein 2 isoform X4 [Ovis aries musimon]>gi|817323870|ref|XP_012332643.1| PREDICTED: actin-related protein 2 isoform X2 [Aotus nancymaae]>gi|826279125|ref|XP_012494663.1| PREDICTED: actin-related protein 2 [Propithecus coquereli]>gi|829767722|ref|XP_012620399.1| PREDICTED: actin-related protein 2 isoform X3 [Microcebus murinus]>gi|852767366|ref|XP_012877988.1| PREDICTED: actin-related protein 2 [Dipodomys ordii]>gi|47117648|sp|P61160.1|ARP2_HUMAN RecName: Full=Actin-related protein 2; AltName: Full=Actin-like protein 2>gi|47117649|sp|P61161.1|ARP2_MOUSE RecName: Full=Actin-related protein 2; AltName: Full=Actin-like protein 2>gi|182627520|sp|A7MB62.1|ARP2_BOVIN RecName: Full=Actin-related protein 2; AltName: Full=Actin-like protein 2 [Bos taurus]>gi|17943200|pdb|1K8K|B Chain B, Crystal Structure Of Arp23 COMPLEX>gi|56966173|pdb|1TYQ|B Chain B, Crystal Structure Of Arp23 COMPLEX WITH BOUND ATP AND Calcium>gi|56966193|pdb|1U2V|B Chain B, Crystal Structure Of Arp23 COMPLEX WITH BOUND ADP AND Calcium>gi|149243010|pdb|2P9I|B Chain B, Crystal Structure Of Bovine Arp23 COMPLEX CO-Crystallized With Adp And Crosslinked With Gluteraldehyde>gi|149243032|pdb|2P9L|B Chain B, Crystal Structure Of Bovine Arp23 COMPLEX>gi|149243039|pdb|2P9N|B Chain B, Crystal Structure Of Bovine Arp23 COMPLEX CO-Crystallized With Adp>gi|149243046|pdb|2P9P|B Chain B, Crystal Structure Of Bovine Arp23 COMPLEX CO-Crystallized With Adp>gi|149243053|pdb|2P9S|B Chain B, Structure Of Bovine Arp23 COMPLEX CO-Crystallized With AtpMG2+>gi|149243060|pdb|2P9U|B Chain B, Crystal Structure Of Bovine Arp23 COMPLEX CO-Crystallized With Amp-Pnp And Calcium>gi|254839229|pdb|3DXK|B Chain B, Structure Of Bos Taurus Arp23 COMPLEX WITH BOUND INHIBITOR Ck0944636>gi|254839236|pdb|3DXM|B Chain B, Structure Of Bos Taurus Arp23 COMPLEX WITH BOUND INHIBITOR Ck0993548>gi|334359569|pdb|3RSE|B Chain B, Structural And Biochemical Characterization Of Two Binding Sites For Nucleation Promoting Factor Wasp-Vca On Arp23 COMPLEX>gi|449802074|pdb|3UKR|B Chain B, Crystal Structure Of Bos Taurus Arp2/3 Complex With Bound Inhibitor Ck-666>gi|449802081|pdb|3UKU|B Chain B, Structure Of Arp2/3 Complex With Bound Inhibitor Ck-869>gi|449802088|pdb|3ULE|B Chain B, Structure Of Bos Taurus Arp2/3 Complex With Bound Inhibitor Ck-869 And Atp>gi|524934073|pdb|4JD2|B Chain B, Crystal Structure Of Bos Taurus Arp2/3 Complex Binding With Mus Musculus Gmf>gi|2282030|gb|AAB64187.1| Arp2 [Homo sapiens]>gi|20380733|gb|AAH27799.1| ARP2 actin-related protein 2 homolog (yeast) [Mus musculus]>gi|26328619|dbj|BAC28048.1| unnamed protein product [Mus musculus]>gi|26353172|dbj|BAC40216.1| unnamed protein product [Mus musculus]>gi|74190292|dbj|BAE37239.1| unnamed protein product [Mus musculus]>gi|119620314|gb|EAW99908.1| ARP2 actin-related protein 2 homolog (yeast), isoform CRA_a [Homo sapiens]>gi|119620316|gb|EAW99910.1| ARP2 actin-related protein 2 homolog (yeast), isoform CRA_a [Homo sapiens]>gi|119620318|gb|EAW99912.1| ARP2 actin-related protein 2 homolog (yeast), isoform CRA_a [Homo sapiens]>gi|119620319|gb|EAW99913.1| ARP2 actin-related protein 2 homolog (yeast), isoform CRA_a [Homo sapiens]>gi|148675879|gb|EDL07826.1| ARP2 actin-related protein 2 homolog (yeast) [Mus musculus]>gi|154425680|gb|AAI51357.1| ACTR2 protein [Bos taurus]>gi|189054812|dbj|BAG37642.1| unnamed protein product [Homo sapiens]>gi|195562213|gb|ACG50178.1| actin-related protein 2-like protein [Sus scrofa]>gi|208967643|dbj|BAG72467.1| ARP2 actin-related protein 2 homolog [synthetic construct]>gi|431912639|gb|ELK14657.1| Actin-related protein 2 [Pteropus alecto]>gi|676264805|gb|KFO21150.1| Actin-related protein 2 [Fukomys damarensis] 675796129 XM_003830901.2 422 0 PREDICTED: Pan paniscus ARP2 actin-related protein 2 homolog (yeast) (ACTR2), transcript variant X2, mRNA K17260 ACTR2, ARP2 actin-related protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K17260 A7MB62 721 2.8e-75 Actin-related protein 2 OS=Bos taurus GN=ACTR2 PE=1 SV=1 PF02376 CUT domain GO:0016482//GO:0006928//GO:0051653//GO:0008356//GO:0007163//GO:0030036//GO:0051321//GO:0033206 cytoplasmic transport//movement of cell or subcellular component//spindle localization//asymmetric cell division//establishment or maintenance of cell polarity//actin cytoskeleton organization//meiotic cell cycle//meiotic cytokinesis GO:0003779//GO:0003677//GO:0005524 actin binding//DNA binding//ATP binding GO:0030478//GO:0005885//GO:0042995 actin cap//Arp2/3 protein complex//cell projection KOG0677 Actin-related protein Arp2/3 complex, subunit Arp2 Cluster-8309.60731 BF_2 15.00 0.40 1859 554886791 XP_005952956.1 562 8.2e-55 PREDICTED: zinc finger protein 235-like [Haplochromis burtoni] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 545 3.2e-54 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF05864//PF07776//PF03604//PF00096//PF13912//PF00412//PF13465//PF01096//PF07975//PF01667 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7)//Zinc-finger associated domain (zf-AD)//DNA directed RNA polymerase, 7 kDa subunit//Zinc finger, C2H2 type//C2H2-type zinc finger//LIM domain//Zinc-finger double domain//Transcription factor S-II (TFIIS)//TFIIH C1-like domain//Ribosomal protein S27 GO:0006206//GO:0006351//GO:0006144//GO:0006412//GO:0042254//GO:0006281 pyrimidine nucleobase metabolic process//transcription, DNA-templated//purine nucleobase metabolic process//translation//ribosome biogenesis//DNA repair GO:0003676//GO:0046872//GO:0003677//GO:0003735//GO:0008270//GO:0003899 nucleic acid binding//metal ion binding//DNA binding//structural constituent of ribosome//zinc ion binding//DNA-directed RNA polymerase activity GO:0005634//GO:0005840//GO:0005622//GO:0005730 nucleus//ribosome//intracellular//nucleolus -- -- Cluster-8309.60744 BF_2 6.92 0.44 947 642914983 XP_008190469.1 511 3.4e-49 PREDICTED: uncharacterized protein LOC103312201 [Tribolium castaneum]>gi|270001377|gb|EEZ97824.1| hypothetical protein TcasGA2_TC000191 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02178 AT hook motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.60749 BF_2 69.83 0.61 5080 478255769 ENN75978.1 183 2.0e-10 hypothetical protein YQE_07511, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00816//PF04905//PF07544//PF02179//PF07517 H-NS histone family//NAB conserved region 2 (NCD2)//RNA polymerase II transcription mediator complex subunit 9//BAG domain//SecA DEAD-like domain GO:0006355//GO:0045892//GO:0006357//GO:0017038 regulation of transcription, DNA-templated//negative regulation of transcription, DNA-templated//regulation of transcription from RNA polymerase II promoter//protein import GO:0051087//GO:0005524//GO:0001104//GO:0003677 chaperone binding//ATP binding//RNA polymerase II transcription cofactor activity//DNA binding GO:0005622//GO:0016020//GO:0005634//GO:0016592 intracellular//membrane//nucleus//mediator complex -- -- Cluster-8309.60755 BF_2 6.00 0.35 1000 478260715 ENN80397.1 510 4.7e-49 hypothetical protein YQE_03181, partial [Dendroctonus ponderosae] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 P25784 465 3.2e-45 Digestive cysteine proteinase 3 OS=Homarus americanus GN=LCP3 PE=2 SV=1 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0008234//GO:0004197 cysteine-type peptidase activity//cysteine-type endopeptidase activity -- -- KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.60757 BF_2 23.00 1.20 1090 642938202 XP_008193760.1 265 1.3e-20 PREDICTED: uncharacterized protein LOC103313115 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60761 BF_2 64.84 0.90 3295 642923122 XP_008193618.1 2651 8.5e-297 PREDICTED: cyclic nucleotide-gated cation channel beta-1 [Tribolium castaneum]>gi|270007574|gb|EFA04022.1| hypothetical protein TcasGA2_TC014251 [Tribolium castaneum] -- -- -- -- -- K04952 CNGB1 cyclic nucleotide gated channel beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04952 Q28181 1066 2.2e-114 Cyclic nucleotide-gated cation channel beta-1 OS=Bos taurus GN=CNGB1 PE=1 SV=1 PF00520//PF11789//PF00440 Ion transport protein//Zinc-finger of the MIZ type in Nse subunit//Bacterial regulatory proteins, tetR family GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0008270//GO:0005216//GO:0003677 zinc ion binding//ion channel activity//DNA binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0499 Cyclic nucleotide-gated cation channel CNCG4 Cluster-8309.60766 BF_2 33.36 2.77 790 91079476 XP_967809.1 460 2.3e-43 PREDICTED: cytochrome b5 [Tribolium castaneum]>gi|270003450|gb|EEZ99897.1| hypothetical protein TcasGA2_TC002681 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49098 215 2.5e-16 Cytochrome b5 OS=Nicotiana tabacum PE=2 SV=1 -- -- -- -- GO:0046872//GO:0020037 metal ion binding//heme binding -- -- KOG0537 Cytochrome b5 Cluster-8309.60774 BF_2 12.48 1.03 792 478255317 ENN75543.1 159 1.9e-08 hypothetical protein YQE_07886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60775 BF_2 13.34 1.43 678 91092264 XP_967363.1 382 2.2e-34 PREDICTED: peptide deformylase, mitochondrial [Tribolium castaneum]>gi|270001218|gb|EEZ97665.1| hypothetical protein TcasGA2_TC016210 [Tribolium castaneum] -- -- -- -- -- K01462 PDF, def peptide deformylase http://www.genome.jp/dbget-bin/www_bget?ko:K01462 Q9HBH1 255 4.9e-21 Peptide deformylase, mitochondrial OS=Homo sapiens GN=PDF PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3137 Peptide deformylase Cluster-8309.60786 BF_2 96.86 0.64 6637 91094669 XP_972505.1 7421 0.0e+00 PREDICTED: intraflagellar transport protein osm-1 [Tribolium castaneum]>gi|270016462|gb|EFA12908.1| hypothetical protein TcasGA2_TC006977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W040 4776 0.0e+00 Intraflagellar transport protein osm-1 OS=Drosophila melanogaster GN=osm-1 PE=3 SV=3 PF13414//PF00637//PF13181//PF00515 TPR repeat//Region in Clathrin and VPS//Tetratricopeptide repeat//Tetratricopeptide repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0005622 intracellular KOG3616 Selective LIM binding factor Cluster-8309.60787 BF_2 49.14 0.31 6918 91094669 XP_972505.1 6022 0.0e+00 PREDICTED: intraflagellar transport protein osm-1 [Tribolium castaneum]>gi|270016462|gb|EFA12908.1| hypothetical protein TcasGA2_TC006977 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W040 3750 0.0e+00 Intraflagellar transport protein osm-1 OS=Drosophila melanogaster GN=osm-1 PE=3 SV=3 PF00400//PF00515//PF13181//PF00637//PF11095//PF13414 WD domain, G-beta repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//Gem-associated protein 7 (Gemin7)//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515 protein binding GO:0032797//GO:0005622 SMN complex//intracellular KOG3616 Selective LIM binding factor Cluster-8309.6079 BF_2 23.27 0.49 2261 642928970 XP_008195639.1 186 4.0e-11 PREDICTED: FK506-binding protein 5-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60791 BF_2 41.66 0.80 2457 546680705 ERL90931.1 1474 1.9e-160 hypothetical protein D910_08274, partial [Dendroctonus ponderosae] 642930215 XM_965099.2 234 9.23638e-117 PREDICTED: Tribolium castaneum protein UBASH3A homolog (LOC658737), transcript variant X1, mRNA K18993 UBASH3, STS ubiquitin-associated and SH3 domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K18993 Q9VCE9 858 2.1e-90 Protein UBASH3A homolog OS=Drosophila melanogaster GN=CG13604 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3734 Predicted phosphoglycerate mutase Cluster-8309.6081 BF_2 98.46 2.81 1753 91094825 XP_971125.1 1656 1.1e-181 PREDICTED: ATPase WRNIP1-like [Tribolium castaneum] -- -- -- -- -- K07478 ycaJ putative ATPase http://www.genome.jp/dbget-bin/www_bget?ko:K07478 Q96S55 1112 5.3e-120 ATPase WRNIP1 OS=Homo sapiens GN=WRNIP1 PE=1 SV=2 PF04851//PF01637//PF07726//PF15926//PF00931//PF00910//PF00158//PF01443//PF05496//PF07728//PF01695//PF14532//PF07724//PF00004 Type III restriction enzyme, res subunit//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//E3 ubiquitin-protein ligase RNF220//NB-ARC domain//RNA helicase//Sigma-54 interaction domain//Viral (Superfamily 1) RNA helicase//Holliday junction DNA helicase ruvB N-terminus//AAA domain (dynein-related subfamily)//IstB-like ATP binding protein//Sigma-54 interaction domain//AAA domain (Cdc48 subfamily)//ATPase family associated with various cellular activities (AAA) GO:0006310//GO:0016567//GO:0006355//GO:0006281//GO:0090263 DNA recombination//protein ubiquitination//regulation of transcription, DNA-templated//DNA repair//positive regulation of canonical Wnt signaling pathway GO:0009378//GO:0003724//GO:0043531//GO:0003723//GO:0003677//GO:0016887//GO:0008134//GO:0005524//GO:0016787 four-way junction helicase activity//RNA helicase activity//ADP binding//RNA binding//DNA binding//ATPase activity//transcription factor binding//ATP binding//hydrolase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG2028 ATPase related to the helicase subunit of the Holliday junction resolvase Cluster-8309.60816 BF_2 21.98 0.57 1894 91080175 XP_970509.1 979 3.7e-103 PREDICTED: organic solute transporter alpha-like protein [Tribolium castaneum]>gi|270005672|gb|EFA02120.1| hypothetical protein TcasGA2_TC007767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VVV2 234 3.7e-18 Organic solute transporter alpha-like protein OS=Drosophila melanogaster GN=CG6836 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60829 BF_2 22.86 0.45 2395 189240709 XP_001813711.1 1887 2.4e-208 PREDICTED: acyl-CoA synthetase family member 2, mitochondrial [Tribolium castaneum]>gi|270013541|gb|EFA09989.1| hypothetical protein TcasGA2_TC012154 [Tribolium castaneum] -- -- -- -- -- K00666 K00666 fatty-acyl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00666 Q0P4F7 1165 5.2e-126 Acyl-CoA synthetase family member 2, mitochondrial OS=Danio rerio GN=acsf2 PE=2 SV=1 PF08290//PF00501 Hepatitis core protein, putative zinc finger//AMP-binding enzyme GO:0009405//GO:0008152 pathogenesis//metabolic process GO:0003824//GO:0005198 catalytic activity//structural molecule activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.60836 BF_2 13.00 0.33 1949 546685591 ERL95078.1 331 5.3e-28 hypothetical protein D910_12348 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5SV66 128 7.5e-06 Coiled-coil domain-containing protein 42A OS=Mus musculus GN=Ccdc42 PE=2 SV=2 PF07851 TMPIT-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.60838 BF_2 12.33 0.35 1747 642929034 XP_008195662.1 501 9.1e-48 PREDICTED: borealin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VLD6 143 1.2e-07 Borealin OS=Drosophila melanogaster GN=borr PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60841 BF_2 3.00 0.44 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60844 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60848 BF_2 180.00 4.81 1853 91076348 XP_966701.1 1604 1.2e-175 PREDICTED: COP9 signalosome complex subunit 2 [Tribolium castaneum]>gi|270002546|gb|EEZ98993.1| hypothetical protein TcasGA2_TC004854 [Tribolium castaneum] 241700453 XM_002411850.1 134 2.69535e-61 Ixodes scapularis COP9 signalosome, subunit CSN2, putative, mRNA K12176 COPS2, CSN2, TRIP15 COP9 signalosome complex subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12176 Q94899 1429 9.8e-157 COP9 signalosome complex subunit 2 OS=Drosophila melanogaster GN=alien PE=1 SV=2 PF00515//PF13181//PF01399//PF13176 Tetratricopeptide repeat//Tetratricopeptide repeat//PCI domain//Tetratricopeptide repeat -- -- GO:0005515 protein binding -- -- KOG1463 26S proteasome regulatory complex, subunit RPN6/PSMD11 Cluster-8309.60852 BF_2 1.00 10.51 232 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60860 BF_2 108.50 2.63 2011 91088999 XP_967603.1 2013 5.0e-223 PREDICTED: frizzled-4 [Tribolium castaneum]>gi|270012807|gb|EFA09255.1| frizzled 4 [Tribolium castaneum] 642932599 XM_962510.2 490 0 PREDICTED: Tribolium castaneum frizzled 4 (LOC655955), mRNA K02354 FZD4, fz4 frizzled 4 http://www.genome.jp/dbget-bin/www_bget?ko:K02354 Q61088 900 2.3e-95 Frizzled-4 OS=Mus musculus GN=Fzd4 PE=1 SV=1 PF01534//PF01392 Frizzled/Smoothened family membrane region//Fz domain GO:0007165//GO:0007275//GO:0016055//GO:0007186//GO:0007166 signal transduction//multicellular organismal development//Wnt signaling pathway//G-protein coupled receptor signaling pathway//cell surface receptor signaling pathway GO:0004930//GO:0042813//GO:0005515 G-protein coupled receptor activity//Wnt-activated receptor activity//protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG3577 Smoothened and related G-protein-coupled receptors Cluster-8309.60861 BF_2 7.28 0.89 630 478256725 ENN76906.1 301 5.1e-25 hypothetical protein YQE_06554, partial [Dendroctonus ponderosae] -- -- -- -- -- K11390 CLYBL citrate lyase subunit beta-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K11390 Q8N0X4 204 3.7e-15 Citrate lyase subunit beta-like protein, mitochondrial OS=Homo sapiens GN=CLYBL PE=1 SV=2 PF03328 HpcH/HpaI aldolase/citrate lyase family -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.60870 BF_2 13.00 0.45 1486 642939274 XP_008192907.1 1037 5.5e-110 PREDICTED: polycomb group protein Psc-like isoform X3 [Tribolium castaneum] -- -- -- -- -- K11459 PCGF4, BMI1 polycomb group RING finger protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11459 P35820 630 3.5e-64 Polycomb group protein Psc OS=Drosophila melanogaster GN=Psc PE=1 SV=2 PF13639//PF05196//PF16685//PF12861//PF11789//PF05184//PF00097//PF12678//PF14634 Ring finger domain//PTN/MK heparin-binding protein family, N-terminal domain//zinc RING finger of MSL2//Anaphase-promoting complex subunit 11 RING-H2 finger//Zinc-finger of the MIZ type in Nse subunit//Saposin-like type B, region 1//Zinc finger, C3HC4 type (RING finger)//RING-H2 zinc finger//zinc-RING finger domain GO:0040007//GO:0007165//GO:0008283//GO:0016567//GO:0006629 growth//signal transduction//cell proliferation//protein ubiquitination//lipid metabolic process GO:0008270//GO:0046872//GO:0008083//GO:0004842//GO:0061630//GO:0005515 zinc ion binding//metal ion binding//growth factor activity//ubiquitin-protein transferase activity//ubiquitin protein ligase activity//protein binding GO:0005680 anaphase-promoting complex KOG2660 Locus-specific chromosome binding proteins Cluster-8309.60873 BF_2 24.82 1.03 1294 478252139 ENN72569.1 382 4.3e-34 hypothetical protein YQE_10794, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8TXI4 134 1.0e-06 DNA double-strand break repair Rad50 ATPase OS=Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) GN=rad50 PE=3 SV=1 PF06315//PF09730//PF06009//PF04111//PF02050//PF00769//PF05557//PF07926//PF06160 Isocitrate dehydrogenase kinase/phosphatase (AceK)//Microtubule-associated protein Bicaudal-D//Laminin Domain II//Autophagy protein Apg6//Flagellar FliJ protein//Ezrin/radixin/moesin family//Mitotic checkpoint protein//TPR/MLP1/MLP2-like protein//Septation ring formation regulator, EzrA GO:0006006//GO:0006935//GO:0000921//GO:0071973//GO:0007094//GO:0007155//GO:0006810//GO:0006914//GO:0006606 glucose metabolic process//chemotaxis//septin ring assembly//bacterial-type flagellum-dependent cell motility//mitotic spindle assembly checkpoint//cell adhesion//transport//autophagy//protein import into nucleus GO:0008092//GO:0016791//GO:0003774//GO:0008772 cytoskeletal protein binding//phosphatase activity//motor activity//[isocitrate dehydrogenase (NADP+)] kinase activity GO:0016020//GO:0019898//GO:0016021//GO:0005940//GO:0005794//GO:0009288//GO:0005737 membrane//extrinsic component of membrane//integral component of membrane//septin ring//Golgi apparatus//bacterial-type flagellum//cytoplasm -- -- Cluster-8309.60874 BF_2 28.26 0.75 1861 642922794 XP_008193328.1 521 4.7e-50 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UXX5 291 9.0e-25 Inter-alpha-trypsin inhibitor heavy chain H6 OS=Homo sapiens GN=ITIH6 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60882 BF_2 1.00 1.66 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60883 BF_2 10.00 0.31 1644 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01599 Ribosomal protein S27a GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-8309.60890 BF_2 3.00 0.70 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60894 BF_2 19.91 1.11 1035 769867825 XP_011645940.1 206 8.7e-14 PREDICTED: LOW QUALITY PROTEIN: tyrosine-protein phosphatase 10D [Pogonomyrmex barbatus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16656//PF00041 Purple acid Phosphatase, N-terminal domain//Fibronectin type III domain GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993//GO:0005515//GO:0046872 acid phosphatase activity//protein binding//metal ion binding -- -- -- -- Cluster-8309.60896 BF_2 7.00 1.41 494 805788495 XP_003703628.2 142 1.1e-06 PREDICTED: cuticle protein-like [Megachile rotundata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF10297 Minimal binding motif of Hap4 for binding to Hap2/3/5 GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.60897 BF_2 3.00 0.53 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60903 BF_2 7.51 0.31 1313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02892 BED zinc finger -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.60904 BF_2 16.00 0.36 2126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60906 BF_2 2.00 0.31 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05821 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) GO:0015992//GO:0006118//GO:0006814//GO:0006744//GO:0006120 proton transport//obsolete electron transport//sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0003954 NADH dehydrogenase (ubiquinone) activity//NADH dehydrogenase activity GO:0005739 mitochondrion -- -- Cluster-8309.60907 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60908 BF_2 4.91 0.31 945 642934752 XP_008197796.1 247 1.4e-18 PREDICTED: transmembrane protein 129 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5ZI25 204 5.6e-15 Transmembrane protein 129 OS=Gallus gallus GN=TMEM129 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60914 BF_2 122.14 1.17 4658 478253799 ENN74091.1 3155 0.0e+00 hypothetical protein YQE_09064, partial [Dendroctonus ponderosae]>gi|546684605|gb|ERL94222.1| hypothetical protein D910_11503 [Dendroctonus ponderosae] -- -- -- -- -- K01280 TPP2 tripeptidyl-peptidase II http://www.genome.jp/dbget-bin/www_bget?ko:K01280 P29144 1597 8.2e-176 Tripeptidyl-peptidase 2 OS=Homo sapiens GN=TPP2 PE=1 SV=4 PF00082//PF09377 Subtilase family//SBDS protein C-terminal domain GO:0006508//GO:0042254 proteolysis//ribosome biogenesis GO:0004252 serine-type endopeptidase activity -- -- KOG1114 Tripeptidyl peptidase II Cluster-8309.60915 BF_2 46.22 2.10 1208 91092542 XP_968010.1 1192 4.7e-128 PREDICTED: nucleoporin Nup43 [Tribolium castaneum]>gi|270006621|gb|EFA03069.1| hypothetical protein TcasGA2_TC010925 [Tribolium castaneum] -- -- -- -- -- K14305 NUP43 nuclear pore complex protein Nup43 http://www.genome.jp/dbget-bin/www_bget?ko:K14305 Q8NFH3 595 3.3e-60 Nucleoporin Nup43 OS=Homo sapiens GN=NUP43 PE=1 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60916 BF_2 29.37 0.71 2022 642934007 XP_008197600.1 825 2.8e-85 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K06210 NMNAT nicotinamide mononucleotide adenylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06210 Q96T66 392 1.9e-36 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 OS=Homo sapiens GN=NMNAT3 PE=1 SV=2 PF03028//PF01467//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//EGF-like domain GO:0007018//GO:0007017//GO:0009058 microtubule-based movement//microtubule-based process//biosynthetic process GO:0003824//GO:0005515//GO:0003777 catalytic activity//protein binding//microtubule motor activity GO:0030286//GO:0005874 dynein complex//microtubule KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.60918 BF_2 182.11 1.46 5522 642928752 XP_008199768.1 3819 0.0e+00 PREDICTED: nephrin isoform X1 [Tribolium castaneum]>gi|642928754|ref|XP_008199769.1| PREDICTED: nephrin isoform X1 [Tribolium castaneum] 642928753 XM_008201547.1 619 0 PREDICTED: Tribolium castaneum nephrin (LOC663184), transcript variant X2, mRNA -- -- -- -- Q9QZS7 215 1.7e-15 Nephrin OS=Mus musculus GN=Nphs1 PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.60933 BF_2 14.00 1.37 714 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60934 BF_2 30.58 0.69 2145 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60941 BF_2 27.76 0.52 2510 642914671 XP_008190309.1 831 7.1e-86 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 2.1e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.60948 BF_2 4.28 0.72 535 478256203 ENN76397.1 591 1.0e-58 hypothetical protein YQE_07058, partial [Dendroctonus ponderosae] -- -- -- -- -- K10773 NTH endonuclease III http://www.genome.jp/dbget-bin/www_bget?ko:K10773 Q2KID2 498 2.6e-49 Endonuclease III-like protein 1 OS=Bos taurus GN=NTHL1 PE=2 SV=1 PF00730//PF00633 HhH-GPD superfamily base excision DNA repair protein//Helix-hairpin-helix motif GO:0006284 base-excision repair GO:0003677 DNA binding -- -- KOG1921 Endonuclease III Cluster-8309.6095 BF_2 53.76 6.50 633 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60951 BF_2 19.77 1.68 778 478258603 ENN78653.1 400 2.1e-36 hypothetical protein YQE_04826, partial [Dendroctonus ponderosae]>gi|546676607|gb|ERL87579.1| hypothetical protein D910_04970 [Dendroctonus ponderosae] -- -- -- -- -- K15439 EEF1E1, AIMP3 eukaryotic translation elongation factor 1 epsilon-1 http://www.genome.jp/dbget-bin/www_bget?ko:K15439 P70102 218 1.1e-16 Eukaryotic translation elongation factor 1 epsilon-1 OS=Cricetulus griseus GN=EEF1E1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.60955 BF_2 4.00 0.73 517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60956 BF_2 5.90 0.52 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.60958 BF_2 2.00 1.05 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60965 BF_2 1.00 0.41 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60967 BF_2 125.11 3.83 1655 189235082 XP_967321.2 1909 4.7e-211 PREDICTED: vacuolar fusion protein CCZ1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T102 1030 1.6e-110 Vacuolar fusion protein CCZ1 homolog OS=Xenopus laevis GN=ccz1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2622 Putative myrosinase precursor Cluster-8309.60968 BF_2 24.38 0.52 2244 189235082 XP_967321.2 1819 1.7e-200 PREDICTED: vacuolar fusion protein CCZ1 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7T102 986 2.8e-105 Vacuolar fusion protein CCZ1 homolog OS=Xenopus laevis GN=ccz1 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2622 Putative myrosinase precursor Cluster-8309.60978 BF_2 22.35 0.51 2126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60980 BF_2 44.81 2.15 1159 642921434 XP_008192864.1 1308 1.6e-141 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P86410 518 2.7e-51 Ral GTPase-activating protein subunit beta OS=Rattus norvegicus GN=Ralgapb PE=1 SV=1 PF02145 Rap/ran-GAP GO:0051056 regulation of small GTPase mediated signal transduction GO:0005096 GTPase activator activity -- -- -- -- Cluster-8309.60984 BF_2 20.20 0.41 2342 642920497 XP_008192376.1 2297 6.8e-256 PREDICTED: head-specific guanylate cyclase [Tribolium castaneum]>gi|270005900|gb|EFA02348.1| hypothetical protein TcasGA2_TC008018 [Tribolium castaneum] 755945261 XM_011301432.1 167 1.54693e-79 PREDICTED: Fopius arisanus head-specific guanylate cyclase (LOC105264506), mRNA K12318 GUCY1A guanylate cyclase soluble subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K12318 Q07093 1642 2.5e-181 Head-specific guanylate cyclase OS=Drosophila melanogaster GN=Gycalpha99B PE=2 SV=2 PF07700//PF00211//PF07701//PF00522 Haem-NO-binding//Adenylate and Guanylate cyclase catalytic domain//Heme NO binding associated//VPR/VPX protein GO:0035556//GO:0009190//GO:0006182//GO:0046039//GO:0019058//GO:0006144 intracellular signal transduction//cyclic nucleotide biosynthetic process//cGMP biosynthetic process//GTP metabolic process//viral life cycle//purine nucleobase metabolic process GO:0004383//GO:0000166//GO:0016849//GO:0020037 guanylate cyclase activity//nucleotide binding//phosphorus-oxygen lyase activity//heme binding GO:0005622//GO:0042025 intracellular//host cell nucleus KOG4171 Adenylate/guanylate kinase Cluster-8309.60987 BF_2 3.00 0.63 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.60998 BF_2 1.00 1.29 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61005 BF_2 19.50 1.02 1090 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6101 BF_2 3.00 0.83 437 641660547 XP_008181531.1 166 1.6e-09 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02727 Copper amine oxidase, N2 domain GO:0009308//GO:0055114 amine metabolic process//oxidation-reduction process GO:0048038//GO:0008131//GO:0005507 quinone binding//primary amine oxidase activity//copper ion binding -- -- -- -- Cluster-8309.6102 BF_2 12.00 0.32 1880 546682771 ERL92660.1 1628 2.0e-178 hypothetical protein D910_09972 [Dendroctonus ponderosae] -- -- -- -- -- K11265 ADCY10 adenylate cyclase 10 http://www.genome.jp/dbget-bin/www_bget?ko:K11265 Q96PN6 540 1.2e-53 Adenylate cyclase type 10 OS=Homo sapiens GN=ADCY10 PE=1 SV=3 PF00211 Adenylate and Guanylate cyclase catalytic domain GO:0035556//GO:0009190 intracellular signal transduction//cyclic nucleotide biosynthetic process GO:0016849 phosphorus-oxygen lyase activity -- -- -- -- Cluster-8309.61023 BF_2 11.00 0.91 792 315057121 ADT71676.1 594 6.8e-59 antilipopolysaccharide factor 2 [Scylla paramamosain] 315057120 HM345950.1 618 0 Scylla paramamosain antilipopolysaccharide factor 2 mRNA, complete cds -- -- -- -- C0KJQ4 185 7.5e-13 Anti-lipopolysaccharide factor OS=Portunus trituberculatus GN=ALF PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61026 BF_2 2.00 0.42 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61028 BF_2 56.00 3.17 1026 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61029 BF_2 178.32 4.11 2102 478258003 ENN78141.1 804 8.1e-83 hypothetical protein YQE_05295, partial [Dendroctonus ponderosae]>gi|546682503|gb|ERL92426.1| hypothetical protein D910_09740 [Dendroctonus ponderosae] -- -- -- -- -- K09537 DNAJC17 DnaJ homolog subfamily C member 17 http://www.genome.jp/dbget-bin/www_bget?ko:K09537 Q91WT4 513 1.8e-50 DnaJ homolog subfamily C member 17 OS=Mus musculus GN=Dnajc17 PE=2 SV=2 PF04111//PF00076 Autophagy protein Apg6//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GO:0006914 autophagy GO:0003676 nucleic acid binding -- -- KOG0691 Molecular chaperone (DnaJ superfamily) Cluster-8309.61034 BF_2 3.79 0.80 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61038 BF_2 13.05 0.50 1379 795010007 XP_011864749.1 482 1.2e-45 PREDICTED: uncharacterized protein LOC105560328 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61048 BF_2 24.00 3.92 543 484759859 YP_007890468.1 374 1.5e-33 cytochrome b (mitochondrion) [Andalucia godoyi]>gi|462269090|gb|AGH23962.1| apocytochrome b (mitochondrion) [Andalucia godoyi] 528540458 AP012528.1 516 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 P0C524 710 6.8e-74 Cytochrome b OS=Oryza sativa subsp. japonica GN=MT-CYB PE=2 SV=1 PF00032 Cytochrome b(C-terminal)/b6/petD GO:0006118 obsolete electron transport GO:0009055//GO:0016491 electron carrier activity//oxidoreductase activity GO:0016020 membrane KOG4663 Cytochrome b Cluster-8309.61049 BF_2 37.00 1.38 1410 501673480 YP_007890763.1 928 2.3e-97 cytochrome b (mitochondrion) [Seculamonas ecuadoriensis]>gi|462269872|gb|AGH24458.1| apocytochrome b (mitochondrion) [Seculamonas ecuadoriensis] 528540458 AP012528.1 1386 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 P07747 1207 4.1e-131 Cytochrome b OS=Triticum aestivum GN=MT-CYB PE=2 SV=3 PF13631//PF05425//PF00033 Cytochrome b(N-terminal)/b6/petB//Copper resistance protein D//Cytochrome b/b6/petB GO:0006118//GO:0022904 obsolete electron transport//respiratory electron transport chain GO:0016491//GO:0009055 oxidoreductase activity//electron carrier activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG4663 Cytochrome b Cluster-8309.61050 BF_2 5.79 0.43 853 387413499 AFJ75811.1 246 1.7e-18 glutathione s-transferase M1 [Sogatella furcifera] -- -- -- -- -- K00799 GST, gst glutathione S-transferase http://www.genome.jp/dbget-bin/www_bget?ko:K00799 Q64L89 160 6.4e-10 Microsomal glutathione S-transferase 1 OS=Bos taurus GN=MGST1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61057 BF_2 11.28 0.52 1199 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61069 BF_2 40.62 0.45 4023 91083969 XP_975121.1 682 2.2e-68 PREDICTED: allatostatin-A receptor [Tribolium castaneum]>gi|270008249|gb|EFA04697.1| hypothetical protein TcasGA2_TC014731 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P30974 152 2.5e-08 Tachykinin-like peptides receptor 86C OS=Drosophila melanogaster GN=TkR86C PE=2 SV=2 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007187//GO:0007186//GO:0007268 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//G-protein coupled receptor signaling pathway//synaptic transmission GO:0004930//GO:0004983 G-protein coupled receptor activity//neuropeptide Y receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.61071 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61074 BF_2 99.65 0.79 5546 642923343 XP_008193710.1 3009 0.0e+00 PREDICTED: homeotic protein spalt-major-like isoform X1 [Tribolium castaneum]>gi|270008162|gb|EFA04610.1| spalt [Tribolium castaneum] 642923348 XM_008195491.1 157 1.33785e-73 PREDICTED: Tribolium castaneum homeotic protein spalt-major-like (LOC103313104), transcript variant X4, mRNA -- -- -- -- P39770 661 3.3e-67 Homeotic protein spalt-major OS=Drosophila melanogaster GN=salm PE=1 SV=3 PF13465//PF00096//PF13912//PF16622 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.61078 BF_2 24.78 0.41 2815 642923343 XP_008193710.1 601 3.7e-59 PREDICTED: homeotic protein spalt-major-like isoform X1 [Tribolium castaneum]>gi|270008162|gb|EFA04610.1| spalt [Tribolium castaneum] 642923348 XM_008195491.1 157 6.74752e-74 PREDICTED: Tribolium castaneum homeotic protein spalt-major-like (LOC103313104), transcript variant X4, mRNA -- -- -- -- Q9ER74 139 5.7e-07 Sal-like protein 1 OS=Mus musculus GN=Sall1 PE=2 SV=1 -- -- -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding GO:0005622 intracellular -- -- Cluster-8309.61086 BF_2 1.00 0.33 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61089 BF_2 3.00 2.30 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61097 BF_2 4.00 0.74 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61103 BF_2 5.00 0.75 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61105 BF_2 106.64 0.51 9115 270014787 EFA11235.1 3807 0.0e+00 hypothetical protein TcasGA2_TC010767 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0KK59 1357 1.1e-147 Protein unc-79 homolog OS=Mus musculus GN=Unc79 PE=1 SV=1 PF08689 Mediator complex subunit Med5 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4820 Involved in anesthetic response in C.elegans Cluster-8309.61107 BF_2 1.00 0.94 322 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61127 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61130 BF_2 27.52 1.63 993 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61135 BF_2 1.00 0.57 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61149 BF_2 31.00 0.79 1929 642917419 XP_008191190.1 874 5.6e-91 PREDICTED: transcription factor Sox-9-B-like [Tribolium castaneum] 645010170 XM_008215211.1 71 2.95059e-26 PREDICTED: Nasonia vitripennis transcription factor SOX-9 (LOC100121308), transcript variant X2, mRNA K09270 SOX7S transcription factor SOX7/8/10/18 (SOX group E/F) http://www.genome.jp/dbget-bin/www_bget?ko:K09270 A5A763 458 4.0e-44 Transcription factor SOX-10 OS=Sus scrofa GN=SOX10 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.61152 BF_2 81.72 2.39 1719 270007077 EFA03525.1 1576 2.0e-172 hypothetical protein TcasGA2_TC013527 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 546 2.2e-54 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61160 BF_2 4.00 0.42 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61161 BF_2 1.00 0.39 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61164 BF_2 159.00 3.53 2170 642915350 XP_008190583.1 493 9.6e-47 PREDICTED: uncharacterized protein LOC663065 isoform X2 [Tribolium castaneum]>gi|270003981|gb|EFA00429.1| hypothetical protein TcasGA2_TC003283 [Tribolium castaneum] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q86MW9 265 1.1e-21 E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni GN=SINA PE=1 SV=1 PF03145 Seven in absentia protein family GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process -- -- GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.61171 BF_2 23.49 0.36 3028 270003330 EEZ99777.1 1507 3.5e-164 hypothetical protein TcasGA2_TC002556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61173 BF_2 221.89 7.58 1512 478250370 ENN70865.1 1009 9.8e-107 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672860|gb|ERL84583.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 625 1.4e-63 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF00975//PF00326//PF07859//PF02230//PF01764 Thioesterase domain//Prolyl oligopeptidase family//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Lipase (class 3) GO:0006508//GO:0008152//GO:0009058//GO:0006629 proteolysis//metabolic process//biosynthetic process//lipid metabolic process GO:0016787//GO:0016788//GO:0008236 hydrolase activity//hydrolase activity, acting on ester bonds//serine-type peptidase activity -- -- -- -- Cluster-8309.61176 BF_2 19.93 0.33 2834 91079032 XP_974956.1 1427 6.2e-155 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270003667|gb|EFA00115.1| hypothetical protein TcasGA2_TC002931 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3D0 209 4.4e-15 Alpha-tocopherol transfer protein-like OS=Mus musculus GN=Ttpal PE=2 SV=3 -- -- GO:0006810 transport GO:0005215 transporter activity GO:0005622 intracellular -- -- Cluster-8309.61177 BF_2 82.67 1.34 2872 642918714 XP_008191551.1 1616 7.7e-177 PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|642918716|ref|XP_008191552.1| PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|270005665|gb|EFA02113.1| hypothetical protein TcasGA2_TC007759 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 P70496 674 5.4e-69 Phospholipase D1 OS=Rattus norvegicus GN=Pld1 PE=1 SV=3 PF02399//PF00787//PF00614 Origin of replication binding protein//PX domain//Phospholipase D Active site motif GO:0006260//GO:0007154//GO:0008152 DNA replication//cell communication//metabolic process GO:0003688//GO:0003824//GO:0005524//GO:0035091 DNA replication origin binding//catalytic activity//ATP binding//phosphatidylinositol binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.61187 BF_2 56.71 86.43 297 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P83653 208 6.0e-16 Antimicrobial peptide Alo-3 OS=Acrocinus longimanus PE=1 SV=1 PF02950 Conotoxin GO:0006810//GO:0009405 transport//pathogenesis GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.61191 BF_2 122.08 2.48 2350 642934168 XP_008199635.1 1894 3.6e-209 PREDICTED: ubiquitin-like modifier-activating enzyme ATG7 [Tribolium castaneum] 641676345 XM_008189159.1 50 1.70183e-14 PREDICTED: Acyrthosiphon pisum ubiquitin-like modifier-activating enzyme ATG7 (LOC100168214), transcript variant X2, mRNA K08337 ATG7 ubiquitin-like modifier-activating enzyme ATG7 http://www.genome.jp/dbget-bin/www_bget?ko:K08337 O95352 1300 1.1e-141 Ubiquitin-like modifier-activating enzyme ATG7 OS=Homo sapiens GN=ATG7 PE=1 SV=1 PF02826//PF00899//PF13241 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//ThiF family//Putative NAD(P)-binding GO:0055114//GO:0006779//GO:0019354 oxidation-reduction process//porphyrin-containing compound biosynthetic process//siroheme biosynthetic process GO:0051287//GO:0008641//GO:0043115 NAD binding//small protein activating enzyme activity//precorrin-2 dehydrogenase activity -- -- KOG2337 Ubiquitin activating E1 enzyme-like protein Cluster-8309.61212 BF_2 3.00 0.36 634 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61214 BF_2 3.23 0.82 451 478256683 ENN76865.1 153 5.3e-08 hypothetical protein YQE_06706, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61215 BF_2 18.78 0.37 2401 91087699 XP_974256.1 900 6.8e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 4.7e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.61223 BF_2 7.30 0.35 1165 642914667 XP_008190306.1 691 5.6e-70 PREDICTED: uncharacterized protein LOC662983 isoform X1 [Tribolium castaneum]>gi|270002279|gb|EEZ98726.1| hypothetical protein TcasGA2_TC001278 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7RTX9 241 3.5e-19 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2504 Monocarboxylate transporter Cluster-8309.61224 BF_2 1.02 0.34 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61225 BF_2 1.00 0.43 382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61232 BF_2 13.00 0.42 1571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61233 BF_2 28.00 0.80 1749 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61234 BF_2 17.00 0.42 1999 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61245 BF_2 133.19 8.04 980 546682632 ERL92547.1 148 4.4e-07 hypothetical protein D910_09860 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61249 BF_2 34.00 3.09 748 642937546 XP_008199090.1 610 9.0e-61 PREDICTED: transmembrane protein C5orf28 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DC75 275 2.6e-23 Transmembrane protein C5orf28 homolog OS=Danio rerio GN=si:busm1-79m10.4 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61261 BF_2 4.00 0.39 718 478249453 ENN70175.1 162 7.6e-09 hypothetical protein YQE_00015 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61262 BF_2 10.90 0.60 1049 514683686 XP_004989424.1 263 2.2e-20 zinc finger protein [Salpingoeca rosetta]>gi|326432905|gb|EGD78475.1| zinc finger protein [Salpingoeca rosetta] -- -- -- -- -- -- -- -- -- P52746 196 5.2e-14 Zinc finger protein 142 OS=Homo sapiens GN=ZNF142 PE=2 SV=4 PF00569//PF13465//PF00096//PF01096//PF02150 Zinc finger, ZZ type//Zinc-finger double domain//Zinc finger, C2H2 type//Transcription factor S-II (TFIIS)//RNA polymerases M/15 Kd subunit GO:0006351//GO:0006144//GO:0006206 transcription, DNA-templated//purine nucleobase metabolic process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0003676//GO:0008270//GO:0046872 DNA binding//DNA-directed RNA polymerase activity//nucleic acid binding//zinc ion binding//metal ion binding GO:0005730 nucleolus -- -- Cluster-8309.61270 BF_2 19.31 0.40 2310 478259929 ENN79731.1 1149 8.7e-123 hypothetical protein YQE_03787, partial [Dendroctonus ponderosae]>gi|546677521|gb|ERL88343.1| hypothetical protein D910_05730 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3U2U7 589 3.1e-59 Methyltransferase-like protein 17, mitochondrial OS=Mus musculus GN=Mettl17 PE=2 SV=2 PF02285//PF09243 Cytochrome oxidase c subunit VIII//Mitochondrial small ribosomal subunit Rsm22 GO:0006412//GO:0015992//GO:0006123 translation//proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129//GO:0008168 cytochrome-c oxidase activity//methyltransferase activity GO:0045277 respiratory chain complex IV KOG2539 Mitochondrial/chloroplast ribosome small subunit component Cluster-8309.61271 BF_2 43.99 0.47 4182 642927459 XP_968905.2 981 4.8e-103 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 698 1.3e-71 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF00107//PF01083//PF01118 Zinc-binding dehydrogenase//Cutinase//Semialdehyde dehydrogenase, NAD binding domain GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016787//GO:0016620//GO:0051287 hydrolase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- -- -- Cluster-8309.61276 BF_2 44.86 1.51 1528 751234819 XP_011171162.1 373 5.6e-33 PREDICTED: uncharacterized protein LOC105203928 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61281 BF_2 75.86 1.97 1897 768425026 XP_011553490.1 530 4.3e-51 PREDICTED: uncharacterized protein LOC105384900 isoform X1 [Plutella xylostella] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61291 BF_2 56.77 0.90 2935 642934576 XP_008197723.1 473 2.7e-44 PREDICTED: uncharacterized protein LOC100142621 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61293 BF_2 1.00 2.33 279 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61296 BF_2 15.24 0.42 1802 642936321 XP_008198395.1 572 5.5e-56 PREDICTED: equilibrative nucleoside transporter 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99P65 165 3.5e-10 Equilibrative nucleoside transporter 3 OS=Mus musculus GN=Slc29a3 PE=1 SV=1 PF01733//PF07690//PF05392 Nucleoside transporter//Major Facilitator Superfamily//Cytochrome C oxidase chain VIIB GO:0006810//GO:0006123//GO:0015858//GO:0055085//GO:0015992 transport//mitochondrial electron transport, cytochrome c to oxygen//nucleoside transport//transmembrane transport//proton transport GO:0004129//GO:0005337 cytochrome-c oxidase activity//nucleoside transmembrane transporter activity GO:0005746//GO:0045277//GO:0016021 mitochondrial respiratory chain//respiratory chain complex IV//integral component of membrane KOG1479 Nucleoside transporter Cluster-8309.61299 BF_2 6.22 0.37 999 642932971 XP_008197211.1 1126 1.8e-120 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 592825523 KJ190519.1 222 1.72486e-110 Bemisia tabaci isolate ASI_TWYL_A2 shaker cognate w gene, partial cds >gnl|BL_ORD_ID|19166192 Bemisia tabaci isolate ASI_SP_A2 shaker cognate w gene, partial cds K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1020 1.4e-109 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF00520 Ion transport protein GO:0055085//GO:0006811 transmembrane transport//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.61303 BF_2 83.37 1.24 3101 642914709 XP_008199908.1 479 5.8e-45 PREDICTED: protein slit-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 220 2.6e-16 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF00560//PF13855 Leucine Rich Repeat//Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.61306 BF_2 21.21 0.33 3014 270015833 EFA12281.1 985 1.2e-103 hypothetical protein TcasGA2_TC005266 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P34457 269 5.2e-22 Putative uncharacterized transposon-derived protein F54H12.3 OS=Caenorhabditis elegans GN=F54H12.3 PE=5 SV=1 PF00907//PF00665 T-box//Integrase core domain GO:0006355//GO:0015074 regulation of transcription, DNA-templated//DNA integration GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.6131 BF_2 3.00 0.66 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61312 BF_2 65.85 1.49 2136 332374612 AEE62447.1 1251 1.2e-134 unknown [Dendroctonus ponderosae] -- -- -- -- -- K14347 SLC10A7, P7 solute carrier family 10 (sodium/bile acid cotransporter), member 7 http://www.genome.jp/dbget-bin/www_bget?ko:K14347 Q52KD1 756 1.2e-78 Sodium/bile acid cotransporter 7-B OS=Xenopus laevis GN=slc10a7-b PE=2 SV=1 PF01758 Sodium Bile acid symporter family -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.6132 BF_2 2.00 0.51 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61326 BF_2 6.00 0.54 753 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61329 BF_2 1.00 8.68 237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6133 BF_2 4.00 1.15 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61342 BF_2 2.00 0.88 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61353 BF_2 1.00 0.42 385 91083481 XP_971741.1 157 1.6e-08 PREDICTED: probable ATP-dependent RNA helicase spindle-E [Tribolium castaneum]>gi|270011114|gb|EFA07562.1| spindle E [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0005488 binding -- -- -- -- Cluster-8309.61361 BF_2 214.00 12.54 1001 642935674 XP_974741.2 521 2.5e-50 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 415 2.0e-39 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06151//PF06320 Trehalose receptor//GCN5-like protein 1 (GCN5L1) GO:0007607//GO:0007187//GO:0050912 obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste GO:0008527 taste receptor activity GO:0031083//GO:0016021 BLOC-1 complex//integral component of membrane KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-8309.61363 BF_2 31.24 0.31 4558 270008606 EFA05054.1 2749 5.1e-308 hypothetical protein TcasGA2_TC015149 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P0CT34 878 1.9e-92 Transposon Tf2-1 polyprotein OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=Tf2-1 PE=3 SV=1 PF00665//PF13683//PF09668//PF16588 Integrase core domain//Integrase core domain//Aspartyl protease//C2H2 zinc-finger GO:0015074//GO:0006508 DNA integration//proteolysis GO:0004190//GO:0003676//GO:0008270 aspartic-type endopeptidase activity//nucleic acid binding//zinc ion binding -- -- -- -- Cluster-8309.61367 BF_2 5.00 0.34 897 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61369 BF_2 3.00 0.32 681 37962892 AAR05800.1 188 7.0e-12 ICHIT [Anopheles gambiae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.61378 BF_2 19.00 0.40 2259 861611749 KMQ85356.1 837 1.3e-86 rna-directed dna polymerase from mobile element jockey-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- P21328 311 5.2e-27 RNA-directed DNA polymerase from mobile element jockey OS=Drosophila melanogaster GN=pol PE=1 SV=1 PF07819 PGAP1-like protein GO:0006505//GO:0006886 GPI anchor metabolic process//intracellular protein transport GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.61379 BF_2 4.00 0.32 813 662216874 XP_008482393.1 239 1.0e-17 PREDICTED: uncharacterized protein LOC103519090 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61385 BF_2 61.51 1.78 1735 260841501 XP_002613951.1 328 1.0e-27 hypothetical protein BRAFLDRAFT_67486 [Branchiostoma floridae]>gi|229299341|gb|EEN69960.1| hypothetical protein BRAFLDRAFT_67486 [Branchiostoma floridae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 A6NN14 308 8.9e-27 Zinc finger protein 729 OS=Homo sapiens GN=ZNF729 PE=2 SV=4 PF00096//PF13465//PF13912//PF15926//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//E3 ubiquitin-protein ligase RNF220//Zinc-finger associated domain (zf-AD) GO:0016567//GO:0090263 protein ubiquitination//positive regulation of canonical Wnt signaling pathway GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.61393 BF_2 5.00 0.42 790 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13508//PF00583//PF08445//PF13673 Acetyltransferase (GNAT) domain//Acetyltransferase (GNAT) family//FR47-like protein//Acetyltransferase (GNAT) domain GO:0042967 acyl-carrier-protein biosynthetic process GO:0008080//GO:0016747 N-acetyltransferase activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.61396 BF_2 21.00 0.41 2438 478252921 ENN73305.1 361 2.2e-31 hypothetical protein YQE_10069, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF12235 Fragile X-related 1 protein core C terminal -- -- GO:0003723 RNA binding -- -- -- -- Cluster-8309.61397 BF_2 101.90 1.24 3736 642926421 XP_008191955.1 1584 5.1e-173 PREDICTED: TWiK family of potassium channels protein 7 [Tribolium castaneum]>gi|642926423|ref|XP_008191956.1| PREDICTED: TWiK family of potassium channels protein 7 [Tribolium castaneum]>gi|270008467|gb|EFA04915.1| hypothetical protein TcasGA2_TC014979 [Tribolium castaneum] 195131168 XM_002009987.1 121 9.2416e-54 Drosophila mojavensis GI14916 (Dmoj\GI14916), mRNA -- -- -- -- Q9ES08 170 1.9e-10 Potassium channel subfamily K member 9 OS=Rattus norvegicus GN=Kcnk9 PE=1 SV=2 PF01007//PF00520//PF17112//PF11857//PF12258 Inward rectifier potassium channel//Ion transport protein//Mitochondrial import receptor subunit Tom6, fungal//Domain of unknown function (DUF3377)//Microcephalin protein GO:0021987//GO:0055085//GO:0006813//GO:0030150//GO:0006811 cerebral cortex development//transmembrane transport//potassium ion transport//protein import into mitochondrial matrix//ion transport GO:0004222//GO:0005242//GO:0005216 metalloendopeptidase activity//inward rectifier potassium channel activity//ion channel activity GO:0016021//GO:0016020//GO:0008076//GO:0005742 integral component of membrane//membrane//voltage-gated potassium channel complex//mitochondrial outer membrane translocase complex -- -- Cluster-8309.61398 BF_2 226.94 3.24 3213 642910641 XP_008200040.1 2497 6.0e-279 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 518 0 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q7Z6J6 772 2.6e-80 FERM domain-containing protein 5 OS=Homo sapiens GN=FRMD5 PE=1 SV=1 PF15168 Triple QxxK/R motif-containing protein family -- -- GO:0008092 cytoskeletal protein binding GO:0005856//GO:0005789//GO:0019898//GO:0005737 cytoskeleton//endoplasmic reticulum membrane//extrinsic component of membrane//cytoplasm KOG3530 FERM domain protein EHM2 Cluster-8309.61399 BF_2 33.38 0.41 3700 642910641 XP_008200040.1 1253 1.2e-134 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 134 5.43051e-61 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q5R803 630 8.8e-64 FERM domain-containing protein 3 OS=Pongo abelii GN=FRMD3 PE=2 SV=1 PF00335//PF01676 Tetraspanin family//Metalloenzyme superfamily -- -- GO:0046872//GO:0008092//GO:0003824 metal ion binding//cytoskeletal protein binding//catalytic activity GO:0005737//GO:0005856//GO:0016021//GO:0019898 cytoplasm//cytoskeleton//integral component of membrane//extrinsic component of membrane KOG3530 FERM domain protein EHM2 Cluster-8309.61402 BF_2 128.67 3.10 2021 332375110 AEE62696.1 1882 7.7e-208 unknown [Dendroctonus ponderosae]>gi|478257862|gb|ENN78004.1| hypothetical protein YQE_05524, partial [Dendroctonus ponderosae]>gi|546674573|gb|ERL85926.1| hypothetical protein D910_03341 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VCA2 693 2.4e-71 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.61404 BF_2 36.00 0.66 2572 642919781 XP_008192063.1 1066 4.1e-113 PREDICTED: LOW QUALITY PROTEIN: uncharacterized protein LOC100142303 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61406 BF_2 38.62 4.73 629 642929003 XP_973340.3 387 5.4e-35 PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|642929005|ref|XP_008195651.1| PREDICTED: alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [Tribolium castaneum] 642929004 XM_008197429.1 40 1.58484e-09 PREDICTED: Tribolium castaneum alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (LOC662130), transcript variant X2, mRNA -- -- -- -- P27808 132 8.3e-07 Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase OS=Mus musculus GN=Mgat1 PE=2 SV=1 PF03071 GNT-I family GO:0006486 protein glycosylation GO:0008375 acetylglucosaminyltransferase activity -- -- KOG1413 N-acetylglucosaminyltransferase I Cluster-8309.61408 BF_2 41.39 0.42 4392 189234308 XP_971839.2 1959 2.0e-216 PREDICTED: solute carrier family 35 member F3 [Tribolium castaneum] -- -- -- -- -- K15288 SLC35F3_4 solute carrier family 35, member F3/4 http://www.genome.jp/dbget-bin/www_bget?ko:K15288 Q1LZI2 549 2.6e-54 Putative thiamine transporter SLC35F3 OS=Mus musculus GN=Slc35f3 PE=2 SV=1 PF06027//PF00892 Solute carrier family 35//EamA-like transporter family GO:0006810 transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG4314 Predicted carbohydrate/phosphate translocator Cluster-8309.61412 BF_2 51.29 1.43 1783 189241899 XP_967370.2 347 6.7e-30 PREDICTED: TP53-regulated inhibitor of apoptosis 1-like [Tribolium castaneum] -- -- -- -- -- K17968 TRIAP1, MDM35 TRIAP1/MDM35 family protein http://www.genome.jp/dbget-bin/www_bget?ko:K17968 O43715 224 5.1e-17 TP53-regulated inhibitor of apoptosis 1 OS=Homo sapiens GN=TRIAP1 PE=1 SV=1 PF11093//PF05051 Mitochondrial export protein Som1//Cytochrome C oxidase copper chaperone (COX17) GO:0006825 copper ion transport GO:0016531//GO:0005507 copper chaperone activity//copper ion binding GO:0005758//GO:0042720 mitochondrial intermembrane space//mitochondrial inner membrane peptidase complex KOG3481 Uncharacterized conserved protein Cluster-8309.61416 BF_2 23.00 0.55 2049 642932676 XP_008196940.1 335 1.9e-28 PREDICTED: uncharacterized protein LOC103314013 [Tribolium castaneum]>gi|642932678|ref|XP_008196941.1| PREDICTED: uncharacterized protein LOC103314013 [Tribolium castaneum]>gi|270011528|gb|EFA07976.1| hypothetical protein TcasGA2_TC005558 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q802Y8 148 3.8e-08 Zinc finger and BTB domain-containing protein 16-A OS=Danio rerio GN=zbtb16a PE=1 SV=1 PF06467//PF05191//PF01155//PF00096 MYM-type Zinc finger with FCS sequence motif//Adenylate kinase, active site lid//Hydrogenase/urease nickel incorporation, metallochaperone, hypA//Zinc finger, C2H2 type GO:0006464//GO:0006144//GO:0046034 cellular protein modification process//purine nucleobase metabolic process//ATP metabolic process GO:0008270//GO:0004017//GO:0046872//GO:0016151 zinc ion binding//adenylate kinase activity//metal ion binding//nickel cation binding -- -- -- -- Cluster-8309.61419 BF_2 89.00 2.98 1536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61426 BF_2 1.00 3.98 260 751446912 XP_011177566.1 141 7.5e-07 PREDICTED: tRNA (guanine-N(7)-)-methyltransferase [Bactrocera cucurbitae] -- -- -- -- -- -- -- -- -- Q29I16 133 2.6e-07 tRNA (guanine-N(7)-)-methyltransferase OS=Drosophila pseudoobscura pseudoobscura GN=GA17913 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG3115 Methyltransferase-like protein Cluster-8309.61428 BF_2 65.00 12.47 505 156553793 XP_001599584.1 629 3.8e-63 PREDICTED: PHD finger-like domain-containing protein 5A [Nasonia vitripennis]>gi|242012971|ref|XP_002427197.1| conserved hypothetical protein [Pediculus humanus corporis]>gi|350395948|ref|XP_003484388.1| PREDICTED: PHD finger-like domain-containing protein 5A [Bombus impatiens]>gi|383850892|ref|XP_003701008.1| PREDICTED: PHD finger-like domain-containing protein 5A [Megachile rotundata]>gi|572316493|ref|XP_006623871.1| PREDICTED: PHD finger-like domain-containing protein 5A-like [Apis dorsata]>gi|746835611|ref|XP_011068502.1| PREDICTED: PHD finger-like domain-containing protein 5A [Acromyrmex echinatior]>gi|749731248|ref|XP_011154391.1| PREDICTED: PHD finger-like domain-containing protein 5A [Harpegnathos saltator]>gi|751223018|ref|XP_011164776.1| PREDICTED: PHD finger-like domain-containing protein 5A [Solenopsis invicta]>gi|752889222|ref|XP_011262550.1| PREDICTED: PHD finger-like domain-containing protein 5A [Camponotus floridanus]>gi|755937688|ref|XP_011297178.1| PREDICTED: PHD finger-like domain-containing protein 5A [Fopius arisanus]>gi|759034616|ref|XP_011334720.1| PREDICTED: PHD finger-like domain-containing protein 5A [Cerapachys biroi]>gi|766923445|ref|XP_011506347.1| PREDICTED: PHD finger-like domain-containing protein 5A [Ceratosolen solmsi marchali]>gi|766923447|ref|XP_011506348.1| PREDICTED: PHD finger-like domain-containing protein 5A [Ceratosolen solmsi marchali]>gi|769854150|ref|XP_011638597.1| PREDICTED: PHD finger-like domain-containing protein 5A isoform X2 [Pogonomyrmex barbatus]>gi|780633537|ref|XP_011686073.1| PREDICTED: PHD finger-like domain-containing protein 5A [Wasmannia auropunctata]>gi|795007852|ref|XP_011858255.1| PREDICTED: PHD finger-like domain-containing protein 5A [Vollenhovia emeryi]>gi|801393085|ref|XP_012058015.1| PREDICTED: PHD finger-like domain-containing protein 5A [Atta cephalotes]>gi|805766705|ref|XP_012135327.1| PREDICTED: PHD finger-like domain-containing protein 5A [Megachile rotundata]>gi|805766713|ref|XP_012135328.1| PREDICTED: PHD finger-like domain-containing protein 5A [Megachile rotundata]>gi|815802989|ref|XP_012222185.1| PREDICTED: PHD finger-like domain-containing protein 5A [Linepithema humile]>gi|817053427|ref|XP_012261946.1| PREDICTED: PHD finger-like domain-containing protein 5A [Athalia rosae]>gi|817195171|ref|XP_012273120.1| PREDICTED: PHD finger-like domain-containing protein 5A [Orussus abietinus]>gi|826422980|ref|XP_012526512.1| PREDICTED: PHD finger-like domain-containing protein 5A [Monomorium pharaonis]>gi|212511484|gb|EEB14459.1| conserved hypothetical protein [Pediculus humanus corporis]>gi|307172921|gb|EFN64088.1| PHD finger-like domain-containing protein 5A [Camponotus floridanus]>gi|307215185|gb|EFN89957.1| PHD finger-like domain-containing protein 5A [Harpegnathos saltator]>gi|322789761|gb|EFZ14927.1| hypothetical protein SINV_12202, partial [Solenopsis invicta]>gi|332029661|gb|EGI69550.1| PHD finger-like domain-containing protein 5A [Acromyrmex echinatior]>gi|607368266|gb|EZA62380.1| PHD finger-like domain-containing protein 5A [Cerapachys biroi]>gi|646709736|gb|KDR15457.1| PHD finger-like domain-containing protein 5A [Zootermopsis nevadensis]>gi|861638037|gb|KMQ92354.1| phd finger-like domain-containing protein 5a protein [Lasius niger] 572316492 XM_006623808.1 161 6.85518e-77 PREDICTED: Apis dorsata PHD finger-like domain-containing protein 5A-like (LOC102675932), mRNA K12834 PHF5A PHD finger-like domain-containing protein 5A http://www.genome.jp/dbget-bin/www_bget?ko:K12834 Q7RTV0 618 2.9e-63 PHD finger-like domain-containing protein 5A OS=Homo sapiens GN=PHF5A PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1705 Uncharacterized conserved protein, contains CXXC motifs Cluster-8309.61431 BF_2 2.00 6.65 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61437 BF_2 34.74 0.78 2159 642913117 XP_008201398.1 1589 7.8e-174 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.5e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61439 BF_2 29.00 0.81 1791 642926791 XP_008195017.1 245 4.5e-18 PREDICTED: uncharacterized protein LOC103313467 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00157//PF17064//PF02778 Pou domain - N-terminal to homeobox domain//Sleepless protein//tRNA intron endonuclease, N-terminal domain GO:0051252//GO:1903818//GO:0030431//GO:0006355//GO:0032222//GO:0006388 regulation of RNA metabolic process//positive regulation of voltage-gated potassium channel activity//sleep//regulation of transcription, DNA-templated//regulation of synaptic transmission, cholinergic//tRNA splicing, via endonucleolytic cleavage and ligation GO:0003700//GO:0000213//GO:0034235 transcription factor activity, sequence-specific DNA binding//tRNA-intron endonuclease activity//GPI anchor binding GO:0000214//GO:0005667 tRNA-intron endonuclease complex//transcription factor complex -- -- Cluster-8309.61457 BF_2 52.79 2.05 1367 374842188 AEL33282.2 1748 1.8e-192 opsin protein [Charybdis japonica] 374842187 HQ856837.2 963 0 Charybdis japonica opsin protein mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25158 1704 9.4e-189 Compound eye opsin BCRH2 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.61459 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61461 BF_2 171.00 1.18 6332 646720734 KDR22356.1 2695 1.3e-301 Protein melted [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9VS24 2301 2.6e-257 Protein melted OS=Drosophila melanogaster GN=melt PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3723 PH domain protein Melted Cluster-8309.61471 BF_2 16.00 0.62 1361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61482 BF_2 155.00 3.55 2116 642927602 XP_008195330.1 594 1.8e-58 PREDICTED: uncharacterized protein LOC662018 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06009 Laminin Domain II GO:0007155 cell adhesion -- -- -- -- -- -- Cluster-8309.61485 BF_2 39.72 1.39 1479 642914621 XP_008190287.1 330 5.2e-28 PREDICTED: uncharacterized protein LOC103312158 [Tribolium castaneum]>gi|270002271|gb|EEZ98718.1| hypothetical protein TcasGA2_TC001264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14833//PF01450 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase//Acetohydroxy acid isomeroreductase, catalytic domain GO:0009099//GO:0055114//GO:0009082//GO:0015940//GO:0009098//GO:0009097 valine biosynthetic process//oxidation-reduction process//branched-chain amino acid biosynthetic process//pantothenate biosynthetic process//leucine biosynthetic process//isoleucine biosynthetic process GO:0004455//GO:0051287 ketol-acid reductoisomerase activity//NAD binding -- -- -- -- Cluster-8309.61489 BF_2 53.01 0.44 5324 642927459 XP_968905.2 1082 1.2e-114 PREDICTED: prostaglandin reductase 1 [Tribolium castaneum] -- -- -- -- -- K13948 PTGR1, LTB4DH prostaglandin reductase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K13948 Q9EQZ5 783 2.3e-81 Prostaglandin reductase 1 OS=Cavia porcellus GN=Ptgr1 PE=1 SV=1 PF01118//PF01083//PF00107 Semialdehyde dehydrogenase, NAD binding domain//Cutinase//Zinc-binding dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0016787//GO:0016620//GO:0051287 hydrolase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//NAD binding -- -- -- -- Cluster-8309.61490 BF_2 21.00 1.11 1079 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03121 Herpesviridae UL52/UL70 DNA primase GO:0006351//GO:0006260//GO:0006269 transcription, DNA-templated//DNA replication//DNA replication, synthesis of RNA primer GO:0003896 DNA primase activity GO:0005730//GO:0005657 nucleolus//replication fork -- -- Cluster-8309.61491 BF_2 2.00 0.55 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61492 BF_2 109.76 1.84 2788 642927980 XP_008195470.1 937 4.0e-98 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N302 473 1.1e-45 Angiogenic factor with G patch and FHA domains 1 OS=Homo sapiens GN=AGGF1 PE=1 SV=2 PF00498//PF07851//PF01585 FHA domain//TMPIT-like protein//G-patch domain -- -- GO:0003676//GO:0005515 nucleic acid binding//protein binding GO:0016021 integral component of membrane KOG0154 RNA-binding protein RBM5 and related proteins, contain G-patch and RRM domains Cluster-8309.61493 BF_2 48.27 1.17 2020 91079362 XP_970302.1 1401 4.6e-152 PREDICTED: islet cell autoantigen 1 [Tribolium castaneum]>gi|270003491|gb|EEZ99938.1| hypothetical protein TcasGA2_TC002734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63054 650 2.3e-66 Islet cell autoantigen 1 OS=Rattus norvegicus GN=Ica1 PE=2 SV=2 PF06456 Arfaptin-like domain -- -- GO:0019904 protein domain specific binding -- -- KOG3891 Secretory vesicle-associated protein ICA69, contains Arfaptin domain Cluster-8309.61498 BF_2 5.00 1.09 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6151 BF_2 9.62 0.54 1027 642936369 XP_008198411.1 623 3.8e-62 PREDICTED: transcription factor E2F5-like [Tribolium castaneum]>gi|270013125|gb|EFA09573.1| hypothetical protein TcasGA2_TC011687 [Tribolium castaneum] 572260333 XM_006608425.1 48 9.4459e-14 PREDICTED: Apis dorsata transcription factor E2F4-like (LOC102673706), transcript variant X2, mRNA K04682 E2F4_5 transcription factor E2F4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04682 Q62814 319 2.8e-28 Transcription factor E2F5 (Fragment) OS=Rattus norvegicus GN=E2f5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.61510 BF_2 15.00 1.90 618 478249935 ENN70442.1 327 4.8e-28 hypothetical protein YQE_12946, partial [Dendroctonus ponderosae]>gi|546679771|gb|ERL90177.1| hypothetical protein D910_07531 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61516 BF_2 29.00 0.54 2534 478263147 ENN81540.1 1450 1.2e-157 hypothetical protein YQE_02069, partial [Dendroctonus ponderosae]>gi|546681780|gb|ERL91806.1| hypothetical protein D910_09131 [Dendroctonus ponderosae] -- -- -- -- -- K02213 CDC6 cell division control protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K02213 Q99741 852 1.1e-89 Cell division control protein 6 homolog OS=Homo sapiens GN=CDC6 PE=1 SV=1 PF03969//PF01637//PF00004//PF00437//PF14532//PF07728//PF05496//PF00158 AFG1-like ATPase//Archaeal ATPase//ATPase family associated with various cellular activities (AAA)//Type II/IV secretion system protein//Sigma-54 interaction domain//AAA domain (dynein-related subfamily)//Holliday junction DNA helicase ruvB N-terminus//Sigma-54 interaction domain GO:0006810//GO:0006281//GO:0006355//GO:0006310 transport//DNA repair//regulation of transcription, DNA-templated//DNA recombination GO:0008134//GO:0005524//GO:0009378//GO:0016887 transcription factor binding//ATP binding//four-way junction helicase activity//ATPase activity GO:0005667//GO:0005657//GO:0009379 transcription factor complex//replication fork//Holliday junction helicase complex KOG2227 Pre-initiation complex, subunit CDC6, AAA+ superfamily ATPase Cluster-8309.61526 BF_2 245.00 2.84 3902 642925330 XP_008194509.1 2130 2.6e-236 PREDICTED: codanin-1 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CC12 901 3.5e-95 Codanin-1 OS=Mus musculus GN=Cdan1 PE=2 SV=2 PF12920 TcdA/TcdB pore forming domain GO:0009405 pathogenesis -- -- -- -- -- -- Cluster-8309.61530 BF_2 9.29 0.59 947 642918135 XP_008194136.1 310 6.9e-26 PREDICTED: WD repeat-containing protein 13-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H1Z4 141 1.1e-07 WD repeat-containing protein 13 OS=Homo sapiens GN=WDR13 PE=1 SV=2 PF05405 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) GO:0015986//GO:0015992 ATP synthesis coupled proton transport//proton transport GO:0015078 hydrogen ion transmembrane transporter activity -- -- -- -- Cluster-8309.61532 BF_2 8.60 0.56 928 478259261 ENN79163.1 264 1.5e-20 hypothetical protein YQE_04348, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00558 Vpu protein GO:0019076//GO:0032801//GO:0006812 viral release from host cell//receptor catabolic process//cation transport GO:0005261 cation channel activity GO:0033644 host cell membrane -- -- Cluster-8309.61535 BF_2 60.50 0.68 4009 805775098 XP_012137658.1 3421 0.0e+00 PREDICTED: DNA (cytosine-5)-methyltransferase PliMCI-like [Megachile rotundata] 641648189 XM_008183068.1 77 2.85844e-29 PREDICTED: Acyrthosiphon pisum DNA (cytosine-5)-methyltransferase PliMCI-like (LOC103308886), mRNA K00558 DNMT1, dcm DNA (cytosine-5)-methyltransferase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K00558 Q24K09 3068 0.0e+00 DNA (cytosine-5)-methyltransferase 1 OS=Bos taurus GN=DNMT1 PE=2 SV=1 PF02008//PF07542//PF01426 CXXC zinc finger domain//ATP12 chaperone protein//BAH domain GO:0043461 proton-transporting ATP synthase complex assembly GO:0008270//GO:0003677//GO:0003682 zinc ion binding//DNA binding//chromatin binding GO:0000785 chromatin -- -- Cluster-8309.61539 BF_2 2.00 0.69 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08030 Ferric reductase NAD binding domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.61544 BF_2 2.00 0.59 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61557 BF_2 19.00 0.91 1160 270013152 EFA09600.1 854 7.1e-89 hypothetical protein TcasGA2_TC011720 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q86B91 316 7.1e-28 Protein tincar OS=Drosophila melanogaster GN=tinc PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61565 BF_2 8.62 0.34 1338 642921056 XP_008192673.1 554 5.0e-54 PREDICTED: hornerin-like [Tribolium castaneum]>gi|270006172|gb|EFA02620.1| hypothetical protein TcasGA2_TC008340 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61566 BF_2 3.00 0.51 534 728418448 AIY68369.1 163 4.3e-09 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61579 BF_2 159.69 3.43 2233 642931828 XP_971231.2 1660 4.7e-182 PREDICTED: F-box/LRR-repeat protein 4 [Tribolium castaneum] -- -- -- -- -- K10270 FBXL4 F-box and leucine-rich repeat protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K10270 Q8BH70 585 8.7e-59 F-box/LRR-repeat protein 4 OS=Mus musculus GN=Fbxl4 PE=2 SV=1 PF00646//PF00560//PF15966//PF12937 F-box domain//Leucine Rich Repeat//F-box//F-box-like -- -- GO:0005515 protein binding -- -- KOG4341 F-box protein containing LRR Cluster-8309.61585 BF_2 26.24 0.64 2009 215274051 ACJ64923.1 1452 5.6e-158 nicotinic acetylcholine receptor alpha 1 [Leptinotarsa decemlineata] 584600361 KF873578.1 374 0 Locusta migratoria strain Js nicotinic acetylcholine receptor alpha1 variant A mRNA, complete cds, alternatively spliced K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P09478 1374 2.5e-150 Acetylcholine receptor subunit alpha-like 1 OS=Drosophila melanogaster GN=nAChRalpha1 PE=2 SV=2 PF02931//PF05491//PF02932//PF06624 Neurotransmitter-gated ion-channel ligand binding domain//Holliday junction DNA helicase ruvB C-terminus//Neurotransmitter-gated ion-channel transmembrane region//Ribosome associated membrane protein RAMP4 GO:0006811//GO:0006310//GO:0006810//GO:0006281 ion transport//DNA recombination//transport//DNA repair GO:0009378//GO:0005230//GO:0003677 four-way junction helicase activity//extracellular ligand-gated ion channel activity//DNA binding GO:0016020//GO:0005783//GO:0009379//GO:0005657 membrane//endoplasmic reticulum//Holliday junction helicase complex//replication fork KOG3645 Acetylcholine receptor Cluster-8309.61586 BF_2 13.42 0.61 1211 215274051 ACJ64923.1 1091 2.4e-116 nicotinic acetylcholine receptor alpha 1 [Leptinotarsa decemlineata] 704529435 XM_010180496.1 39 1.12626e-08 PREDICTED: Mesitornis unicolor cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4), mRNA K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P09478 634 9.8e-65 Acetylcholine receptor subunit alpha-like 1 OS=Drosophila melanogaster GN=nAChRalpha1 PE=2 SV=2 PF02932 Neurotransmitter-gated ion-channel transmembrane region GO:0006811 ion transport -- -- GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.61589 BF_2 3.00 8.65 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61590 BF_2 54.00 2.18 1323 226968626 YP_002808575.1 859 2.1e-89 NADH dehydrogenase subunit 2 [Scylla paramamosain]>gi|225697862|gb|ACO07229.1| NADH dehydrogenase subunit 2 [Scylla paramamosain] 225697849 FJ827761.1 1309 0 Scylla paramamosain mitochondrion, complete genome -- -- -- -- P03895 353 4.1e-32 NADH-ubiquinone oxidoreductase chain 2 OS=Drosophila yakuba GN=mt:ND2 PE=3 SV=1 -- -- GO:0055114 oxidation-reduction process -- -- GO:0016020 membrane -- -- Cluster-8309.61591 BF_2 20.00 0.50 1951 501295171 BAN20835.1 1543 1.5e-168 four and a half lim domains [Riptortus pedestris] 689574286 LM044152.1 56 6.50696e-18 Toxocara canis genome assembly T_canis_Equador ,scaffold TCNE_contig0001497 K14380 FHL2 four and a half LIM domains protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K14380 Q2KI95 968 3.0e-103 Four and a half LIM domains protein 2 OS=Bos taurus GN=FHL2 PE=2 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1704 FOG: LIM domain Cluster-8309.61593 BF_2 18.16 0.45 1962 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61607 BF_2 87.75 0.91 4334 546685829 ERL95272.1 1486 1.4e-161 hypothetical protein D910_12538, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q7TMV3 207 1.2e-14 FAST kinase domain-containing protein 5 OS=Mus musculus GN=Fastkd5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6161 BF_2 39.00 0.89 2117 478257458 ENN77614.1 1415 1.1e-153 hypothetical protein YQE_05909, partial [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 797 2.2e-83 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF05493//PF00916//PF06459 ATP synthase subunit H//Sulfate permease family//Ryanodine Receptor TM 4-6 GO:0006816//GO:0008272//GO:0015991//GO:0015992//GO:0006874 calcium ion transport//sulfate transport//ATP hydrolysis coupled proton transport//proton transport//cellular calcium ion homeostasis GO:0015116//GO:0005219//GO:0015078 sulfate transmembrane transporter activity//ryanodine-sensitive calcium-release channel activity//hydrogen ion transmembrane transporter activity GO:0016021//GO:0005622//GO:0033179 integral component of membrane//intracellular//proton-transporting V-type ATPase, V0 domain KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.61628 BF_2 2.00 1.33 345 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61629 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61631 BF_2 44.00 1.61 1427 717007159 AIW68607.1 1627 2.0e-178 glyceraldehyde-3-phosphate-dehydrogenase [Cherax quadricarinatus] 402485601 JX257000.1 1410 0 Scylla paramamosain glyceraldehyde-3-phosphate dehydrogenase mRNA, complete cds K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P56649 1609 1.0e-177 Glyceraldehyde-3-phosphate dehydrogenase OS=Panulirus versicolor PE=1 SV=1 PF00044//PF02826//PF02800 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain//Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0051287//GO:0016620 NAD binding//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-8309.61636 BF_2 18.36 1.03 1035 189235467 XP_001814003.1 457 6.9e-43 PREDICTED: chymotrypsin-1 [Tribolium castaneum]>gi|270004829|gb|EFA01277.1| serine protease P40 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7SIG2 302 2.7e-26 Chymotrypsin-1 OS=Solenopsis invicta PE=1 SV=1 PF02452//PF00089 PemK-like, MazF-like toxin of type II toxin-antitoxin system//Trypsin GO:0006508 proteolysis GO:0003677//GO:0016787//GO:0004252 DNA binding//hydrolase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.61637 BF_2 6.00 0.49 801 478254862 ENN75098.1 272 1.5e-21 hypothetical protein YQE_08411, partial [Dendroctonus ponderosae] -- -- -- -- -- K13356 FAR fatty acyl-CoA reductase http://www.genome.jp/dbget-bin/www_bget?ko:K13356 Q66H50 168 7.1e-11 Fatty acyl-CoA reductase 1 OS=Rattus norvegicus GN=Far1 PE=2 SV=1 PF01073//PF01370 3-beta hydroxysteroid dehydrogenase/isomerase family//NAD dependent epimerase/dehydratase family GO:0008210//GO:0006694//GO:0055114//GO:0008209//GO:0008207 estrogen metabolic process//steroid biosynthetic process//oxidation-reduction process//androgen metabolic process//C21-steroid hormone metabolic process GO:0016616//GO:0003854//GO:0003824//GO:0050662 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//3-beta-hydroxy-delta5-steroid dehydrogenase activity//catalytic activity//coenzyme binding -- -- KOG1221 Acyl-CoA reductase Cluster-8309.61649 BF_2 41.54 0.54 3480 260783431 XP_002586778.1 587 1.9e-57 hypothetical protein BRAFLDRAFT_102936 [Branchiostoma floridae]>gi|229271904|gb|EEN42789.1| hypothetical protein BRAFLDRAFT_102936 [Branchiostoma floridae] -- -- -- -- -- -- -- -- -- Q05481 392 3.3e-36 Zinc finger protein 91 OS=Homo sapiens GN=ZNF91 PE=2 SV=2 PF02150//PF00096//PF13465//PF07776//PF07649 RNA polymerases M/15 Kd subunit//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//C1-like domain GO:0006144//GO:0006351//GO:0055114//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//oxidation-reduction process//pyrimidine nucleobase metabolic process GO:0003677//GO:0003899//GO:0047134//GO:0046872//GO:0008270 DNA binding//DNA-directed RNA polymerase activity//protein-disulfide reductase activity//metal ion binding//zinc ion binding GO:0005634//GO:0005730 nucleus//nucleolus -- -- Cluster-8309.61666 BF_2 99.00 1.18 3802 478258638 ENN78688.1 572 1.2e-55 hypothetical protein YQE_04860, partial [Dendroctonus ponderosae] -- -- -- -- -- K09414 HSF1 heat shock transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09414 P38532 443 4.3e-42 Heat shock factor protein 1 OS=Mus musculus GN=Hsf1 PE=1 SV=2 PF00447 HSF-type DNA-binding GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex KOG0627 Heat shock transcription factor Cluster-8309.61672 BF_2 12.12 3.79 420 642922790 XP_008193326.1 225 2.2e-16 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P56652 149 5.9e-09 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Bos taurus GN=ITIH3 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6169 BF_2 2.00 0.91 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61698 BF_2 8.03 0.45 1042 237681149 NP_001153721.1 220 2.1e-15 ATP-dependent RNA helicase belle [Tribolium castaneum]>gi|270008148|gb|EFA04596.1| belle [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:1901363//GO:0016787//GO:0097159 heterocyclic compound binding//hydrolase activity//organic cyclic compound binding -- -- -- -- Cluster-8309.61701 BF_2 13.00 0.43 1563 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61715 BF_2 25.69 2.08 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.61716 BF_2 4.31 1.36 419 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08039 Mitochondrial proteolipid -- -- -- -- GO:0005739 mitochondrion -- -- Cluster-8309.61720 BF_2 40.65 0.93 2112 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61721 BF_2 7.66 0.42 1056 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61725 BF_2 6.82 0.54 814 91077334 XP_974850.1 374 2.3e-33 PREDICTED: amidophosphoribosyltransferase [Tribolium castaneum]>gi|270001665|gb|EEZ98112.1| hypothetical protein TcasGA2_TC000530 [Tribolium castaneum] -- -- -- -- -- K00764 purF, PPAT amidophosphoribosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00764 Q27601 302 2.1e-26 Amidophosphoribosyltransferase OS=Drosophila melanogaster GN=Prat PE=1 SV=2 -- -- GO:0009113//GO:0006536//GO:0006144//GO:0006189//GO:0006541//GO:0009116 purine nucleobase biosynthetic process//glutamate metabolic process//purine nucleobase metabolic process//'de novo' IMP biosynthetic process//glutamine metabolic process//nucleoside metabolic process GO:0046872//GO:0004044//GO:0051536 metal ion binding//amidophosphoribosyltransferase activity//iron-sulfur cluster binding -- -- KOG0572 Glutamine phosphoribosylpyrophosphate amidotransferase Cluster-8309.61727 BF_2 7.00 1.36 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61734 BF_2 1.40 0.44 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61738 BF_2 58.00 12.90 475 238683667 ACR54112.1 278 1.8e-22 ribosomal protein P1 [Palaemon varians] 262401192 FJ774778.1 214 2.2129e-106 Scylla paramamosain putative 60S acidic ribosomal protein P1 mRNA, partial cds K02942 RP-LP1, RPLP1 large subunit ribosomal protein LP1 http://www.genome.jp/dbget-bin/www_bget?ko:K02942 P02402 239 2.5e-19 60S acidic ribosomal protein P1 OS=Artemia salina PE=1 SV=2 PF01213//PF01698 Adenylate cyclase associated (CAP) N terminal//Floricaula / Leafy protein GO:0006355//GO:0007010 regulation of transcription, DNA-templated//cytoskeleton organization GO:0003677//GO:0003779 DNA binding//actin binding -- -- KOG1762 60s acidic ribosomal protein P1 Cluster-8309.61745 BF_2 16.08 0.31 2487 546681015 ERL91180.1 1694 6.0e-186 hypothetical protein D910_08519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q04519 680 9.4e-70 Sphingomyelin phosphodiesterase OS=Mus musculus GN=Smpd1 PE=2 SV=2 PF00149 Calcineurin-like phosphoesterase -- -- GO:0016787 hydrolase activity -- -- KOG3770 Acid sphingomyelinase and PHM5 phosphate metabolism protein Cluster-8309.61756 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61760 BF_2 10.10 0.49 1148 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61761 BF_2 11.00 0.90 796 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61780 BF_2 7.00 0.47 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61781 BF_2 8.00 0.46 1013 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61782 BF_2 9.00 0.69 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03606 C4-dicarboxylate anaerobic carrier -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.61786 BF_2 58.20 0.86 3132 642932892 XP_008197175.1 620 2.6e-61 PREDICTED: uncharacterized protein LOC103314074 [Tribolium castaneum]>gi|270011476|gb|EFA07924.1| hypothetical protein TcasGA2_TC005502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61790 BF_2 17.53 0.62 1476 546678978 ERL89511.1 413 1.2e-37 hypothetical protein D910_06877 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.618 BF_2 22.55 0.39 2737 270014082 EFA10530.1 1284 2.3e-138 hypothetical protein TcasGA2_TC012784 [Tribolium castaneum] 642936326 XM_964264.3 365 0 PREDICTED: Tribolium castaneum hemicentin-2-like (LOC657829), transcript variant X1, mRNA -- -- -- -- Q62718 136 1.2e-06 Neurotrimin OS=Rattus norvegicus GN=Ntm PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61801 BF_2 12.08 0.46 1384 270008057 EFA04505.1 996 2.9e-105 hypothetical protein TcasGA2_TC014813 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y624 141 1.6e-07 Junctional adhesion molecule A OS=Homo sapiens GN=F11R PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61804 BF_2 16.00 0.55 1499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01466 Skp1 family, dimerisation domain GO:0006511 ubiquitin-dependent protein catabolic process -- -- -- -- -- -- Cluster-8309.61811 BF_2 11.00 0.91 791 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61817 BF_2 8.00 0.50 959 358256649 GAA57881.1 141 2.8e-06 hypothetical protein CLF_113308 [Clonorchis sinensis] 601040144 KJ013364.1 608 0 Uncultured bacterium clone 11-860 16S ribosomal RNA gene, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61826 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61831 BF_2 58.73 1.42 2016 642921794 XP_970012.2 1840 5.7e-203 PREDICTED: protein FAM73B [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5BLE2 717 3.9e-74 Protein FAM73B OS=Danio rerio GN=fam73b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3831 Uncharacterized conserved protein Cluster-8309.61837 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61838 BF_2 3.00 0.57 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61852 BF_2 83.75 5.43 932 642917092 XP_008191113.1 794 5.2e-82 PREDICTED: U6 snRNA phosphodiesterase [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6DEF6 489 4.9e-48 U6 snRNA phosphodiesterase OS=Danio rerio GN=usb1 PE=2 SV=1 PF09749 Uncharacterised conserved protein GO:0034477 U6 snRNA 3'-end processing GO:0004518 nuclease activity -- -- KOG3102 Uncharacterized conserved protein Cluster-8309.61859 BF_2 124.71 1.67 3412 332374784 AEE62533.1 1039 7.4e-110 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8SWR3 136 1.5e-06 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.61862 BF_2 17.29 0.53 1662 332374784 AEE62533.1 867 3.2e-90 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8SWR3 136 7.5e-07 Sex peptide receptor OS=Drosophila melanogaster GN=SPR PE=1 SV=1 PF01226//PF00001 Formate/nitrite transporter//7 transmembrane receptor (rhodopsin family) GO:0006810//GO:0007186 transport//G-protein coupled receptor signaling pathway GO:0005215//GO:0004930 transporter activity//G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.61863 BF_2 34.03 4.55 600 642929994 XP_008196057.1 217 2.7e-15 PREDICTED: uncharacterized protein LOC664557 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61864 BF_2 3.00 0.41 590 641669191 XP_008184720.1 186 1.0e-11 PREDICTED: testican-1 isoform X1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06524//PF02724//PF04931//PF04147 NOA36 protein//CDC45-like protein//DNA polymerase phi//Nop14-like family GO:0006260//GO:0006270//GO:0006351 DNA replication//DNA replication initiation//transcription, DNA-templated GO:0008270//GO:0003887//GO:0003677 zinc ion binding//DNA-directed DNA polymerase activity//DNA binding GO:0032040//GO:0042575//GO:0005634 small-subunit processome//DNA polymerase complex//nucleus -- -- Cluster-8309.61865 BF_2 8.00 0.47 999 751813228 AJG01361.1 878 1.0e-91 sarcoplasmic calcium-binding protein variant c [Eriocheir sinensis] 387571562 JQ860424.1 830 0 Scylla paramamosain sarcoplasmic calcium-binding protein (SCP) mRNA, complete cds -- -- -- -- P05946 839 1.4e-88 Sarcoplasmic calcium-binding protein 1 OS=Astacus leptodactylus PE=1 SV=1 PF12763//PF13202//PF13499//PF13833//PF13405//PF00036 Cytoskeletal-regulatory complex EF hand//EF hand//EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- -- -- Cluster-8309.61870 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61871 BF_2 44.86 0.48 4224 688556539 XP_009300010.1 1306 1.0e-140 PREDICTED: general transcription factor II-I repeat domain-containing protein 2-like [Danio rerio] -- -- -- -- -- -- -- -- -- A4IFA3 913 1.5e-96 General transcription factor II-I repeat domain-containing protein 2 OS=Bos taurus GN=GTF2IRD2 PE=2 SV=1 PF05699//PF00253 hAT family C-terminal dimerisation region//Ribosomal protein S14p/S29e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0046983 structural constituent of ribosome//protein dimerization activity GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.61881 BF_2 22.95 0.72 1630 642926106 XP_008194787.1 1739 2.4e-191 PREDICTED: rabphilin-3A [Tribolium castaneum] 462477511 APGK01000290.1 49 4.21718e-14 Dendroctonus ponderosae Seq01000290, whole genome shotgun sequence -- -- -- -- Q06846 589 2.2e-59 Rabphilin-3A OS=Bos taurus GN=RPH3A PE=1 SV=1 PF05715//PF00168//PF01363 Piccolo Zn-finger//C2 domain//FYVE zinc finger -- -- GO:0005515//GO:0046872 protein binding//metal ion binding GO:0045202 synapse KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.61883 BF_2 1.00 13.93 225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61884 BF_2 8.00 0.40 1127 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05270 Alpha-L-arabinofuranosidase B (ABFB) domain GO:0046373//GO:0009117//GO:0005975 L-arabinose metabolic process//nucleotide metabolic process//carbohydrate metabolic process GO:0046556 alpha-L-arabinofuranosidase activity -- -- -- -- Cluster-8309.61886 BF_2 11.00 0.32 1720 189239358 XP_974445.2 1222 2.2e-131 PREDICTED: tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like [Tribolium castaneum] 817088660 XM_012411735.1 54 7.40246e-17 PREDICTED: Athalia rosae tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like (LOC105692505), transcript variant X2, mRNA K05545 DUS4 tRNA-dihydrouridine synthase 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05545 Q32M08 710 2.2e-73 tRNA-dihydrouridine(20a/20b) synthase [NAD(P)+]-like OS=Mus musculus GN=Dus4l PE=2 SV=1 PF00977//PF01207 Histidine biosynthesis protein//Dihydrouridine synthase (Dus) GO:0000105//GO:0055114//GO:0008033 histidine biosynthetic process//oxidation-reduction process//tRNA processing GO:0050660//GO:0017150 flavin adenine dinucleotide binding//tRNA dihydrouridine synthase activity -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.61899 BF_2 8.18 0.51 960 642929723 XP_008195952.1 619 1.0e-61 PREDICTED: spastin [Tribolium castaneum]>gi|270010589|gb|EFA07037.1| hypothetical protein TcasGA2_TC010011 [Tribolium castaneum] -- -- -- -- -- K13254 SPAST spastin http://www.genome.jp/dbget-bin/www_bget?ko:K13254 Q7QBW0 429 4.6e-41 Spastin OS=Anopheles gambiae GN=spas PE=3 SV=6 PF13414//PF00515 TPR repeat//Tetratricopeptide repeat -- -- GO:0008568//GO:0005524//GO:0005515 microtubule-severing ATPase activity//ATP binding//protein binding -- -- -- -- Cluster-8309.61900 BF_2 11.15 1.19 680 478249761 ENN70269.1 542 6.2e-53 hypothetical protein YQE_13052, partial [Dendroctonus ponderosae]>gi|546677441|gb|ERL88278.1| hypothetical protein D910_05665 [Dendroctonus ponderosae] -- -- -- -- -- K13254 SPAST spastin http://www.genome.jp/dbget-bin/www_bget?ko:K13254 Q7QBW0 435 6.6e-42 Spastin OS=Anopheles gambiae GN=spas PE=3 SV=6 PF13414//PF00515//PF13181//PF14863 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Alkyl sulfatase dimerisation -- -- GO:0005515//GO:0046983 protein binding//protein dimerization activity -- -- -- -- Cluster-8309.61901 BF_2 14.00 0.97 888 780168081 XP_011684075.1 280 2.0e-22 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Strongylocentrotus purpuratus] -- -- -- -- -- K15502 ANKRD28 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A http://www.genome.jp/dbget-bin/www_bget?ko:K15502 Q8N8A2 237 7.8e-19 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B OS=Homo sapiens GN=ANKRD44 PE=1 SV=3 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.61907 BF_2 14.06 0.91 933 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04614 Pex19 protein family -- -- -- -- GO:0005777 peroxisome -- -- Cluster-8309.6191 BF_2 9.00 0.40 1220 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61912 BF_2 40.91 1.96 1160 270002473 EEZ98920.1 700 5.1e-71 hypothetical protein TcasGA2_TC004539 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7Z2Q7 221 7.3e-17 Leucine-rich repeat-containing protein 70 OS=Homo sapiens GN=LRRC70 PE=2 SV=1 PF13855 Leucine rich repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.61920 BF_2 21.88 1.74 812 189238253 XP_001813297.1 960 2.5e-101 PREDICTED: GPN-loop GTPase 3 [Tribolium castaneum]>gi|270008652|gb|EFA05100.1| hypothetical protein TcasGA2_TC015199 [Tribolium castaneum] -- -- -- -- -- K06883 K06883 uncharacterized protein http://www.genome.jp/dbget-bin/www_bget?ko:K06883 Q9D3W4 705 3.9e-73 GPN-loop GTPase 3 OS=Mus musculus GN=Gpn3 PE=2 SV=1 PF01926//PF00005//PF00910//PF00437//PF00004 50S ribosome-binding GTPase//ABC transporter//RNA helicase//Type II/IV secretion system protein//ATPase family associated with various cellular activities (AAA) GO:0006810 transport GO:0003724//GO:0016887//GO:0003723//GO:0005525//GO:0005524//GO:0000166 RNA helicase activity//ATPase activity//RNA binding//GTP binding//ATP binding//nucleotide binding -- -- KOG1534 Putative transcription factor FET5 Cluster-8309.61922 BF_2 10.06 0.31 1654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61923 BF_2 2.00 0.86 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61934 BF_2 26.00 0.83 1601 270005566 EFA02014.1 507 1.7e-48 hypothetical protein TcasGA2_TC007637 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09026 Centromere protein B dimerisation domain GO:0006355 regulation of transcription, DNA-templated GO:0003682//GO:0003677 chromatin binding//DNA binding GO:0000775//GO:0000785//GO:0005634 chromosome, centromeric region//chromatin//nucleus -- -- Cluster-8309.61935 BF_2 18.00 0.62 1497 642919228 XP_008191786.1 1583 2.7e-173 PREDICTED: dachshund homolog 1 [Tribolium castaneum] 642919227 XM_008193564.1 365 0 PREDICTED: Tribolium castaneum dachshund homolog 1 (LOC652934), mRNA -- -- -- -- Q9UI36 497 9.4e-49 Dachshund homolog 1 OS=Homo sapiens GN=DACH1 PE=1 SV=3 PF07535 DBF zinc finger -- -- GO:0003676//GO:0008270 nucleic acid binding//zinc ion binding -- -- KOG3915 Transcription regulator dachshund, contains SKI/SNO domain Cluster-8309.61943 BF_2 11.54 0.42 1423 270012018 EFA08466.1 819 9.9e-85 hypothetical protein TcasGA2_TC006115 [Tribolium castaneum] -- -- -- -- -- K10769 ALKBH7 alkylated DNA repair protein alkB homolog 7 http://www.genome.jp/dbget-bin/www_bget?ko:K10769 Q9D6Z0 506 8.1e-50 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial OS=Mus musculus GN=Alkbh7 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.61947 BF_2 4.00 0.51 618 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61950 BF_2 9.24 0.44 1170 861594808 KMQ83108.1 691 5.7e-70 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61955 BF_2 40.00 0.94 2066 270009491 EFA05939.1 270 6.6e-21 hypothetical protein TcasGA2_TC008755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61959 BF_2 111.71 2.30 2321 642933166 XP_008197284.1 2057 4.5e-228 PREDICTED: hexosaminidase D-like [Tribolium castaneum]>gi|270012547|gb|EFA08995.1| hypothetical protein TcasGA2_TC006702 [Tribolium castaneum] -- -- -- -- -- K14459 HEX hexosaminidase http://www.genome.jp/dbget-bin/www_bget?ko:K14459 Q8WVB3 769 4.2e-80 Hexosaminidase D OS=Homo sapiens GN=HEXDC PE=2 SV=3 PF00728 Glycosyl hydrolase family 20, catalytic domain GO:0005975 carbohydrate metabolic process GO:0043169//GO:0004553 cation binding//hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.6196 BF_2 11.00 0.33 1702 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61960 BF_2 201.57 2.60 3525 642925895 XP_008190722.1 1469 1.0e-159 PREDICTED: uncharacterized protein LOC661054 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q63416 801 1.2e-83 Inter-alpha-trypsin inhibitor heavy chain H3 OS=Rattus norvegicus GN=Itih3 PE=2 SV=1 PF08496 Peptidase family S49 N-terminal -- -- GO:0004252 serine-type endopeptidase activity GO:0005886 plasma membrane -- -- Cluster-8309.61962 BF_2 2.00 0.72 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.61963 BF_2 10.66 0.95 758 642914286 XP_008201622.1 278 2.9e-22 PREDICTED: CCR4-NOT transcription complex subunit 6-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K12603 CNOT6, CCR4 CCR4-NOT transcription complex subunit 6 http://www.genome.jp/dbget-bin/www_bget?ko:K12603 A2BHJ4 162 3.3e-10 CCR4-NOT transcription complex subunit 6-like OS=Danio rerio GN=cnot6l PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0620 Glucose-repressible alcohol dehydrogenase transcriptional effector CCR4 and related proteins Cluster-8309.61969 BF_2 12.00 1.17 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06005 Protein of unknown function (DUF904) GO:0000917//GO:0043093 barrier septum assembly//FtsZ-dependent cytokinesis -- -- GO:0005737 cytoplasm -- -- Cluster-8309.61973 BF_2 1.00 1.46 299 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6198 BF_2 2.00 0.45 474 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09907 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.61980 BF_2 22.68 0.75 1555 665820747 XP_008559286.1 1162 1.8e-124 PREDICTED: guanine nucleotide-binding protein subunit beta-5 [Microplitis demolitor] 807025222 XM_004523529.2 155 4.77562e-73 PREDICTED: Ceratitis capitata guanine nucleotide-binding protein subunit beta-5 (LOC101456443), mRNA K04539 GNB5 guanine nucleotide-binding protein subunit beta-5 http://www.genome.jp/dbget-bin/www_bget?ko:K04539 P62882 914 4.3e-97 Guanine nucleotide-binding protein subunit beta-5 OS=Rattus norvegicus GN=Gnb5 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0286 G-protein beta subunit Cluster-8309.61997 BF_2 60.45 2.37 1354 546674258 ERL85677.1 887 1.2e-92 hypothetical protein D910_03093 [Dendroctonus ponderosae] -- -- -- -- -- K07918 RAB32 Ras-related protein Rab-32 http://www.genome.jp/dbget-bin/www_bget?ko:K07918 Q55E31 501 2.9e-49 Ras-related protein Rab-32B OS=Dictyostelium discoideum GN=rab32B PE=3 SV=1 PF00025//PF00071//PF01926//PF03193//PF08477 ADP-ribosylation factor family//Ras family//50S ribosome-binding GTPase//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0007264 small GTPase mediated signal transduction GO:0003924//GO:0005525 GTPase activity//GTP binding -- -- -- -- Cluster-8309.62 BF_2 12.00 2.93 458 22758848 AAN05584.1 515 5.7e-50 ribosomal protein L30 [Argopecten irradians] 172051117 EU574827.1 107 6.44021e-47 Ornithodoros coriaceus clone OC-30 ribosomal protein L30 mRNA, partial cds K02908 RP-L30e, RPL30 large subunit ribosomal protein L30e http://www.genome.jp/dbget-bin/www_bget?ko:K02908 P67884 481 2.0e-47 60S ribosomal protein L30 OS=Ophiophagus hannah GN=RPL30 PE=3 SV=2 -- -- -- -- -- -- -- -- KOG2988 60S ribosomal protein L30 Cluster-8309.62001 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62003 BF_2 11.00 0.66 988 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62009 BF_2 1.00 0.48 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62011 BF_2 40.00 0.75 2524 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04689 DNA binding protein S1FA GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.62021 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62029 BF_2 3.00 0.33 672 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62030 BF_2 3.17 0.40 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62031 BF_2 8.07 0.47 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62032 BF_2 22.00 0.35 2913 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62036 BF_2 18.72 0.81 1254 414448076 AFW99840.1 521 3.1e-50 troponin I [Litopenaeus vannamei] 414448055 JX683730.1 312 2.02941e-160 Litopenaeus vannamei clone TPNi3 troponin I mRNA, complete cds -- -- -- -- P05547 519 2.2e-51 Troponin I OS=Astacus leptodactylus PE=1 SV=1 PF00992 Troponin -- -- -- -- GO:0005861 troponin complex KOG3977 Troponin I Cluster-8309.62040 BF_2 36.00 0.83 2094 642918792 XP_008191586.1 583 3.4e-57 PREDICTED: derriere protein-like [Tribolium castaneum] -- -- -- -- -- K04664 GDF5_6_7 growth differentiation factor 5/6/7 http://www.genome.jp/dbget-bin/www_bget?ko:K04664 Q9YGV1 232 7.0e-18 Derriere protein OS=Xenopus laevis GN=derriere PE=1 SV=1 PF00019//PF12763//PF00688 Transforming growth factor beta like domain//Cytoskeletal-regulatory complex EF hand//TGF-beta propeptide GO:0040007//GO:0007165//GO:0008283 growth//signal transduction//cell proliferation GO:0008083//GO:0005515 growth factor activity//protein binding -- -- -- -- Cluster-8309.62043 BF_2 3.00 0.50 537 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62058 BF_2 1.00 0.48 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62067 BF_2 12.00 0.33 1795 542258197 XP_005464423.1 728 4.5e-74 PREDICTED: zinc finger protein 569-like isoform X1 [Oreochromis niloticus]>gi|542258199|ref|XP_005464424.1| PREDICTED: zinc finger protein 569-like isoform X2 [Oreochromis niloticus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q61116 711 1.7e-73 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF00096//PF13465//PF13912//PF07776 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Zinc-finger associated domain (zf-AD) -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.62070 BF_2 15.00 0.50 1540 675369431 KFM62333.1 174 6.7e-10 CCAAT/enhancer-binding protein gamma, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P53568 130 3.5e-06 CCAAT/enhancer-binding protein gamma OS=Mus musculus GN=Cebpg PE=1 SV=1 PF04977//PF07851//PF04111//PF00424//PF00170//PF07716//PF06005 Septum formation initiator//TMPIT-like protein//Autophagy protein Apg6//REV protein (anti-repression trans-activator protein)//bZIP transcription factor//Basic region leucine zipper//Protein of unknown function (DUF904) GO:0000917//GO:0043093//GO:0007049//GO:0006355//GO:0006914 barrier septum assembly//FtsZ-dependent cytokinesis//cell cycle//regulation of transcription, DNA-templated//autophagy GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005737//GO:0005667//GO:0042025//GO:0016021 cytoplasm//transcription factor complex//host cell nucleus//integral component of membrane -- -- Cluster-8309.62077 BF_2 3.00 0.41 591 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62080 BF_2 1.00 0.56 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62089 BF_2 14.47 0.37 1911 607361066 EZA55368.1 392 4.4e-35 hypothetical protein X777_04821 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62092 BF_2 78.03 2.05 1879 642921031 XP_008192662.1 635 2.8e-63 PREDICTED: harmonin isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62094 BF_2 14.00 0.48 1504 642921434 XP_008192864.1 334 1.8e-28 PREDICTED: ral GTPase-activating protein subunit beta isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BQZ4 218 2.1e-16 Ral GTPase-activating protein subunit beta OS=Mus musculus GN=Ralgapb PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3652 Uncharacterized conserved protein Cluster-8309.62095 BF_2 67.32 1.99 1704 478253895 ENN74187.1 1290 2.9e-139 hypothetical protein YQE_09160, partial [Dendroctonus ponderosae]>gi|546674898|gb|ERL86184.1| hypothetical protein D910_03597 [Dendroctonus ponderosae]>gi|546684705|gb|ERL94322.1| hypothetical protein D910_11603 [Dendroctonus ponderosae]>gi|546686838|gb|ERL95869.1| hypothetical protein D910_00502 [Dendroctonus ponderosae] -- -- -- -- -- K08831 SRPK2 serine/threonine-protein kinase SRPK2 http://www.genome.jp/dbget-bin/www_bget?ko:K08831 P78362 494 2.4e-48 SRSF protein kinase 2 OS=Homo sapiens GN=SRPK2 PE=1 SV=3 PF07714//PF00069//PF05445 Protein tyrosine kinase//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- KOG1290 Serine/threonine protein kinase Cluster-8309.62097 BF_2 66.21 1.33 2370 270014581 EFA11029.1 1291 3.1e-139 hypothetical protein TcasGA2_TC004618 [Tribolium castaneum] -- -- -- -- -- K08831 SRPK2 serine/threonine-protein kinase SRPK2 http://www.genome.jp/dbget-bin/www_bget?ko:K08831 P78362 494 3.3e-48 SRSF protein kinase 2 OS=Homo sapiens GN=SRPK2 PE=1 SV=3 PF07714//PF00069//PF05445 Protein tyrosine kinase//Protein kinase domain//Poxvirus serine/threonine protein kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG1290 Serine/threonine protein kinase Cluster-8309.62120 BF_2 34.00 2.59 836 74844658 Q95V34.1 1055 2.5e-112 RecName: Full=40S ribosomal protein S4 [Spodoptera frugiperda]>gi|16566725|gb|AAL26580.1|AF429978_1 ribosomal protein S4 [Spodoptera frugiperda] 262401340 FJ774852.1 439 0 Scylla paramamosain ribosomal protein S4 mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q4GXU6 1055 1.0e-113 40S ribosomal protein S4 OS=Carabus granulatus GN=RpS4 PE=2 SV=1 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.62123 BF_2 5.00 1.23 457 645006679 XP_008204884.1 160 8.3e-09 PREDICTED: orexin receptor type 1-like isoform X1 [Nasonia vitripennis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62127 BF_2 14.04 0.37 1875 642918767 XP_008191575.1 1211 4.6e-130 PREDICTED: heparanase-like [Tribolium castaneum] -- -- -- -- -- K07964 HPSE heparanase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07964 Q9MYY0 715 6.2e-74 Heparanase OS=Bos taurus GN=HPSE PE=2 SV=2 PF03662 Glycosyl hydrolase family 79, N-terminal domain -- -- GO:0016798 hydrolase activity, acting on glycosyl bonds GO:0016020 membrane -- -- Cluster-8309.62134 BF_2 4.00 0.53 605 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62146 BF_2 8.40 0.57 901 478252437 ENN72860.1 385 1.3e-34 hypothetical protein YQE_10509, partial [Dendroctonus ponderosae]>gi|546673468|gb|ERL85066.1| hypothetical protein D910_02489 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01292 Prokaryotic cytochrome b561 GO:0006118 obsolete electron transport GO:0009055 electron carrier activity GO:0016021 integral component of membrane -- -- Cluster-8309.62165 BF_2 4.00 0.82 492 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62180 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62181 BF_2 2.54 0.34 604 546679552 ERL90000.1 563 2.0e-55 hypothetical protein D910_07359 [Dendroctonus ponderosae] -- -- -- -- -- K14163 EPRS bifunctional glutamyl/prolyl-tRNA synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K14163 Q8CGC7 460 7.4e-45 Bifunctional glutamate/proline--tRNA ligase OS=Mus musculus GN=Eprs PE=1 SV=4 PF00458 WHEP-TRS domain GO:0006418 tRNA aminoacylation for protein translation GO:0005524//GO:0004812 ATP binding//aminoacyl-tRNA ligase activity -- -- KOG4163 Prolyl-tRNA synthetase Cluster-8309.62183 BF_2 29.48 0.42 3204 817212181 XP_012282266.1 793 2.3e-81 PREDICTED: uncharacterized protein LOC105700713 [Orussus abietinus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02563//PF02066 Polysaccharide biosynthesis/export protein//Metallothionein family 11 GO:0015774 polysaccharide transport GO:0005507//GO:0015159 copper ion binding//polysaccharide transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.62184 BF_2 3.00 0.48 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00937 Coronavirus nucleocapsid protein -- -- -- -- GO:0019013 viral nucleocapsid -- -- Cluster-8309.62189 BF_2 16.30 0.72 1239 478258272 ENN78401.1 311 7.0e-26 hypothetical protein YQE_05201, partial [Dendroctonus ponderosae]>gi|546683474|gb|ERL93280.1| hypothetical protein D910_10576 [Dendroctonus ponderosae] -- -- -- -- -- K15151 MED10, NUT2 mediator of RNA polymerase II transcription subunit 10 http://www.genome.jp/dbget-bin/www_bget?ko:K15151 Q7Q5R5 273 7.3e-23 Mediator of RNA polymerase II transcription subunit 10 OS=Anopheles gambiae GN=MED10 PE=3 SV=2 PF09748 Transcription factor subunit Med10 of Mediator complex GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG3046 Transcription factor, subunit of SRB subcomplex of RNA polymerase II Cluster-8309.6219 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62199 BF_2 9.00 0.32 1456 478250947 ENN71431.1 293 1.0e-23 hypothetical protein YQE_11850, partial [Dendroctonus ponderosae]>gi|546682685|gb|ERL92597.1| hypothetical protein D910_09910 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q00690 171 5.8e-11 E-selectin OS=Mus musculus GN=Sele PE=2 SV=1 PF08114 ATPase proteolipid family GO:0050790 regulation of catalytic activity GO:0030234 enzyme regulator activity -- -- -- -- Cluster-8309.62202 BF_2 14.61 2.25 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0006886//GO:0015031//GO:0008277 intracellular protein transport//protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.62212 BF_2 11.17 0.34 1673 189241520 XP_968500.2 471 2.6e-44 PREDICTED: set1/Ash2 histone methyltransferase complex subunit ASH2 isoform X2 [Tribolium castaneum] -- -- -- -- -- K14964 ASH2 Set1/Ash2 histone methyltransferase complex subunit ASH2 http://www.genome.jp/dbget-bin/www_bget?ko:K14964 Q94545 375 1.5e-34 Set1/Ash2 histone methyltransferase complex subunit ASH2 OS=Drosophila melanogaster GN=ash2 PE=1 SV=2 PF00622 SPRY domain -- -- GO:0005515 protein binding -- -- KOG2626 Histone H3 (Lys4) methyltransferase complex, subunit CPS60/ASH2/BRE2 Cluster-8309.62213 BF_2 1.00 1.13 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62218 BF_2 1.00 0.71 340 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62219 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62220 BF_2 13.68 0.64 1178 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62224 BF_2 2.00 0.31 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62232 BF_2 11.00 1.08 715 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.62239 BF_2 2.00 0.31 555 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62244 BF_2 1.00 0.42 385 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05924 SAMP Motif GO:0016055 Wnt signaling pathway GO:0008013 beta-catenin binding GO:0016342 catenin complex -- -- Cluster-8309.62258 BF_2 5.32 0.54 700 642923986 XP_008193958.1 222 8.2e-16 PREDICTED: dystrobrevin beta [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62261 BF_2 2.00 0.32 545 642913005 XP_008201349.1 143 9.2e-07 PREDICTED: synaptic vesicle glycoprotein 2C-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07690//PF00083//PF04574 Major Facilitator Superfamily//Sugar (and other) transporter//Protein of unknown function (DUF592) GO:0006807//GO:0006355//GO:0006342//GO:0006476//GO:0055085 nitrogen compound metabolic process//regulation of transcription, DNA-templated//chromatin silencing//protein deacetylation//transmembrane transport GO:0008270//GO:0051287//GO:0017136//GO:0016811//GO:0022857 zinc ion binding//NAD binding//NAD-dependent histone deacetylase activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides//transmembrane transporter activity GO:0000118//GO:0016021 histone deacetylase complex//integral component of membrane -- -- Cluster-8309.62263 BF_2 4.00 3.71 323 307197589 EFN78794.1 216 1.9e-15 hypothetical protein EAI_16705, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62267 BF_2 47.48 1.86 1357 642923261 XP_008193681.1 1300 1.6e-140 PREDICTED: T-cell activation inhibitor, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 417 1.6e-39 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62271 BF_2 6.00 1.94 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62274 BF_2 4.00 0.74 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62277 BF_2 138.00 1.10 5537 189237499 XP_971802.2 3233 0.0e+00 PREDICTED: probable multidrug resistance-associated protein lethal(2)03659 [Tribolium castaneum]>gi|270007691|gb|EFA04139.1| hypothetical protein TcasGA2_TC014383 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 P91660 1139 1.2e-122 Probable multidrug resistance-associated protein lethal(2)03659 OS=Drosophila melanogaster GN=l(2)03659 PE=2 SV=3 PF00005//PF03193//PF06414//PF00931//PF01580//PF08477//PF00664//PF01350//PF01443//PF13304//PF01926//PF00437 ABC transporter//Protein of unknown function, DUF258//Zeta toxin//NB-ARC domain//FtsK/SpoIIIE family//Ras of Complex, Roc, domain of DAPkinase//ABC transporter transmembrane region//Flavivirus non-structural protein NS4A//Viral (Superfamily 1) RNA helicase//AAA domain, putative AbiEii toxin, Type IV TA system//50S ribosome-binding GTPase//Type II/IV secretion system protein GO:0055085//GO:0006810//GO:0016032//GO:0016070//GO:0007264 transmembrane transport//transport//viral process//RNA metabolic process//small GTPase mediated signal transduction GO:0005524//GO:0003924//GO:0000166//GO:0016887//GO:0016301//GO:0042626//GO:0003677//GO:0043531//GO:0005525//GO:0017111 ATP binding//GTPase activity//nucleotide binding//ATPase activity//kinase activity//ATPase activity, coupled to transmembrane movement of substances//DNA binding//ADP binding//GTP binding//nucleoside-triphosphatase activity GO:0016021//GO:0019012 integral component of membrane//virion -- -- Cluster-8309.62282 BF_2 25.46 0.39 3030 91086047 XP_973605.1 3516 0.0e+00 PREDICTED: protein turtle homolog B [Tribolium castaneum] 642927616 XM_968512.2 548 0 PREDICTED: Tribolium castaneum protein turtle homolog B (LOC662415), mRNA -- -- -- -- Q9R044 237 2.7e-18 Nephrin OS=Rattus norvegicus GN=Nphs1 PE=1 SV=2 PF00041//PF13895 Fibronectin type III domain//Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62283 BF_2 46.61 1.57 1533 546684831 ERL94413.1 661 2.2e-66 hypothetical protein D910_11691 [Dendroctonus ponderosae] -- -- -- -- -- K01719 hemD, UROS uroporphyrinogen-III synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01719 P51163 305 1.8e-26 Uroporphyrinogen-III synthase OS=Mus musculus GN=Uros PE=2 SV=1 PF02602//PF11380 Uroporphyrinogen-III synthase HemD//Stealth protein CR2, conserved region 2 GO:0033014//GO:0006783//GO:0015994 tetrapyrrole biosynthetic process//heme biosynthetic process//chlorophyll metabolic process GO:0004852//GO:0016772 uroporphyrinogen-III synthase activity//transferase activity, transferring phosphorus-containing groups -- -- -- -- Cluster-8309.62289 BF_2 9.54 0.71 851 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6229 BF_2 105.00 2.35 2157 270006939 EFA03387.1 211 4.8e-14 hypothetical protein TcasGA2_TC013373 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01105 emp24/gp25L/p24 family/GOLD GO:0006810 transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.62295 BF_2 12.79 1.42 663 795010872 XP_011869493.1 530 1.5e-51 PREDICTED: uncharacterized protein LOC105562922, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6230 BF_2 2.00 0.48 460 391347360 XP_003747932.1 468 1.6e-44 PREDICTED: uncharacterized protein LOC100900611 isoform 1 [Metaseiulus occidentalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01384 Phosphate transporter family GO:0006817 phosphate ion transport GO:0005315 inorganic phosphate transmembrane transporter activity GO:0016020 membrane -- -- Cluster-8309.62308 BF_2 7.09 0.31 1247 478255012 ENN75245.1 463 1.7e-43 hypothetical protein YQE_08254, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28DS0 177 1.0e-11 SUMO-activating enzyme subunit 1 OS=Xenopus tropicalis GN=sae1 PE=2 SV=1 PF00899 ThiF family -- -- GO:0008641 small protein activating enzyme activity -- -- -- -- Cluster-8309.62315 BF_2 55.33 0.93 2776 91077390 XP_975277.1 1616 7.4e-177 PREDICTED: chromatin assembly factor 1 subunit B [Tribolium castaneum]>gi|270001646|gb|EEZ98093.1| hypothetical protein TcasGA2_TC000506 [Tribolium castaneum] -- -- -- -- -- K10751 CHAF1B chromatin assembly factor 1 subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K10751 Q13112 816 1.8e-85 Chromatin assembly factor 1 subunit B OS=Homo sapiens GN=CHAF1B PE=1 SV=1 PF00400//PF10584 WD domain, G-beta repeat//Proteasome subunit A N-terminal signature GO:0006511 ubiquitin-dependent protein catabolic process GO:0004175//GO:0005515 endopeptidase activity//protein binding GO:0019773 proteasome core complex, alpha-subunit complex KOG1009 Chromatin assembly complex 1 subunit B/CAC2 (contains WD40 repeats) Cluster-8309.62322 BF_2 27.74 0.54 2424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62324 BF_2 27.55 1.73 953 332372560 AEE61422.1 762 2.7e-78 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5ZKX6 537 1.4e-53 NEDD8-conjugating enzyme UBE2F OS=Gallus gallus GN=UBE2F PE=2 SV=1 PF08001 CMV US GO:0030683 evasion or tolerance by virus of host immune response -- -- GO:0044386 integral to host endoplasmic reticulum membrane KOG0420 Ubiquitin-protein ligase Cluster-8309.62325 BF_2 94.42 0.83 5018 332372560 AEE61422.1 791 6.2e-81 unknown [Dendroctonus ponderosae]>gi|478257372|gb|ENN77530.1| hypothetical protein YQE_05978, partial [Dendroctonus ponderosae]>gi|546685343|gb|ERL94870.1| hypothetical protein D910_12143 [Dendroctonus ponderosae] -- -- -- -- -- K10687 UBE2F ubiquitin-conjugating enzyme E2 F http://www.genome.jp/dbget-bin/www_bget?ko:K10687 Q5M8Y2 566 3.1e-56 NEDD8-conjugating enzyme UBE2F OS=Xenopus tropicalis GN=ube2f PE=2 SV=1 PF05482 Serendipity locus alpha protein (SRY-A) GO:0007349 cellularization -- -- GO:0005737//GO:0016020 cytoplasm//membrane KOG0420 Ubiquitin-protein ligase Cluster-8309.62339 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05739 SNARE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62341 BF_2 2.00 0.34 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62346 BF_2 2.00 3.12 296 -- -- -- -- -- 262401360 FJ774862.1 135 1.08481e-62 Scylla paramamosain hypothetical protein mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62352 BF_2 2.48 0.80 416 759063913 XP_011341347.1 464 4.2e-44 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 isoform X9 [Cerapachys biroi] 642930305 XM_008198117.1 117 1.60229e-52 PREDICTED: Tribolium castaneum potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 (LOC659555), transcript variant X5, mRNA K04957 HCN4 hyperpolarization activated cyclic nucleotide-gated potassium channel 4 http://www.genome.jp/dbget-bin/www_bget?ko:K04957 Q9TV66 320 8.7e-29 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 OS=Oryctolagus cuniculus GN=HCN4 PE=2 SV=1 PF02962 5-carboxymethyl-2-hydroxymuconate isomerase GO:0018874//GO:0019439//GO:0006570 benzoate metabolic process//aromatic compound catabolic process//tyrosine metabolic process GO:0008704 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity -- -- -- -- Cluster-8309.62354 BF_2 29.47 0.81 1812 642917767 XP_008191359.1 1321 7.8e-143 PREDICTED: glucose dehydrogenase [FAD, quinone]-like [Tribolium castaneum]>gi|270003384|gb|EEZ99831.1| hypothetical protein TcasGA2_TC002612 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P18172 821 3.0e-86 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF00732//PF05199//PF02254 GMC oxidoreductase//GMC oxidoreductase//TrkA-N domain GO:0006813//GO:0055114 potassium ion transport//oxidation-reduction process GO:0016614//GO:0050660 oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding -- -- -- -- Cluster-8309.62356 BF_2 8.65 1.04 636 546683633 ERL93421.1 257 6.5e-20 hypothetical protein D910_10713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62358 BF_2 1.00 0.45 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62365 BF_2 2.00 1.08 361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62366 BF_2 12.00 0.36 1663 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62369 BF_2 1.00 0.87 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62372 BF_2 1.00 0.68 343 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6238 BF_2 1.00 0.36 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62393 BF_2 4.00 0.63 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62394 BF_2 268.26 2.40 4956 189237952 XP_001813626.1 2230 8.4e-248 PREDICTED: methyltransferase-like protein 13 [Tribolium castaneum]>gi|270008036|gb|EFA04484.1| hypothetical protein TcasGA2_TC014789 [Tribolium castaneum] 332372815 BT126586.1 117 2.05636e-51 Dendroctonus ponderosae clone DPO1019_N08 unknown mRNA K16185 RRAGA_B Ras-related GTP-binding protein A/B http://www.genome.jp/dbget-bin/www_bget?ko:K16185 Q9VIK9 1576 2.4e-173 Methyltransferase-like protein 13 OS=Drosophila melanogaster GN=CG2614 PE=2 SV=1 PF01209//PF00484//PF04670//PF00071//PF10662//PF00005//PF03193//PF07516//PF08241//PF05175//PF05724//PF00503//PF00025//PF02390//PF08477//PF01926 ubiE/COQ5 methyltransferase family//Carbonic anhydrase//Gtr1/RagA G protein conserved region//Ras family//Ethanolamine utilisation - propanediol utilisation//ABC transporter//Protein of unknown function, DUF258//SecA Wing and Scaffold domain//Methyltransferase domain//Methyltransferase small domain//Thiopurine S-methyltransferase (TPMT)//G-protein alpha subunit//ADP-ribosylation factor family//Putative methyltransferase//Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase GO:0009451//GO:0007264//GO:0032259//GO:0006400//GO:0006807//GO:0006576//GO:0008152//GO:0006730//GO:0007186//GO:0008033//GO:0007165//GO:0017038 RNA modification//small GTPase mediated signal transduction//methylation//tRNA modification//nitrogen compound metabolic process//cellular biogenic amine metabolic process//metabolic process//one-carbon metabolic process//G-protein coupled receptor signaling pathway//tRNA processing//signal transduction//protein import GO:0005525//GO:0004871//GO:0008176//GO:0008757//GO:0004089//GO:0008270//GO:0008168//GO:0019001//GO:0016887//GO:0005524//GO:0031683//GO:0003924 GTP binding//signal transducer activity//tRNA (guanine-N7-)-methyltransferase activity//S-adenosylmethionine-dependent methyltransferase activity//carbonate dehydratase activity//zinc ion binding//methyltransferase activity//guanyl nucleotide binding//ATPase activity//ATP binding//G-protein beta/gamma-subunit complex binding//GTPase activity GO:0016020 membrane KOG3886 GTP-binding protein Cluster-8309.62405 BF_2 2.00 0.50 454 478251115 ENN71591.1 249 3.9e-19 hypothetical protein YQE_11691, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02244 Carboxypeptidase activation peptide GO:0006508 proteolysis GO:0004180 carboxypeptidase activity -- -- -- -- Cluster-8309.62406 BF_2 14.89 0.33 2177 817076793 XP_012260690.1 974 1.6e-102 PREDICTED: uncharacterized protein LOC105688742 [Athalia rosae] -- -- -- -- -- K01291 CPB1 carboxypeptidase B http://www.genome.jp/dbget-bin/www_bget?ko:K01291 P04069 706 7.9e-73 Carboxypeptidase B OS=Astacus astacus PE=1 SV=1 PF00246 Zinc carboxypeptidase GO:0006508 proteolysis GO:0004181//GO:0008270 metallocarboxypeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.62414 BF_2 7.64 1.33 527 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6242 BF_2 13.00 0.52 1330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62422 BF_2 1.00 1.91 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62424 BF_2 59.99 1.44 2025 189239087 XP_968222.2 852 2.1e-88 PREDICTED: DNA polymerase epsilon subunit 2 [Tribolium castaneum] -- -- -- -- -- K02325 POLE2 DNA polymerase epsilon subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02325 P56282 534 6.5e-53 DNA polymerase epsilon subunit 2 OS=Homo sapiens GN=POLE2 PE=1 SV=2 PF04042//PF05132 DNA polymerase alpha/epsilon subunit B//RNA polymerase III RPC4 GO:0006144//GO:0006383//GO:0006351//GO:0006206//GO:0006260 purine nucleobase metabolic process//transcription from RNA polymerase III promoter//transcription, DNA-templated//pyrimidine nucleobase metabolic process//DNA replication GO:0003887//GO:0003899//GO:0003677 DNA-directed DNA polymerase activity//DNA-directed RNA polymerase activity//DNA binding GO:0042575//GO:0005730//GO:0005666 DNA polymerase complex//nucleolus//DNA-directed RNA polymerase III complex KOG3818 DNA polymerase epsilon, subunit B Cluster-8309.6243 BF_2 3.00 0.82 440 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6244 BF_2 1.02 0.40 392 478257525 ENN77680.1 154 3.5e-08 hypothetical protein YQE_05831, partial [Dendroctonus ponderosae]>gi|546677868|gb|ERL88620.1| hypothetical protein D910_06005 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62441 BF_2 11.00 0.35 1615 642915291 XP_008190557.1 364 6.5e-32 PREDICTED: serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K15424 PPP4R1 serine/threonine-protein phosphatase 4 regulatory subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15424 Q8VI02 160 1.2e-09 Serine/threonine-protein phosphatase 4 regulatory subunit 1 OS=Rattus norvegicus GN=Ppp4r1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62442 BF_2 6.00 0.80 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62446 BF_2 20.00 0.73 1434 270014336 EFA10784.1 594 1.2e-58 goosecoid [Tribolium castaneum] -- -- -- -- -- K09324 GSC homeobox protein goosecoid http://www.genome.jp/dbget-bin/www_bget?ko:K09324 A1YEY5 164 3.7e-10 Homeobox protein goosecoid OS=Gorilla gorilla gorilla GN=GSC PE=3 SV=1 PF00046 Homeobox domain -- -- GO:0003677 DNA binding -- -- KOG0490 Transcription factor, contains HOX domain Cluster-8309.62448 BF_2 1.62 2.26 301 332376733 AEE63506.1 223 2.7e-16 unknown [Dendroctonus ponderosae]>gi|478250681|gb|ENN71173.1| hypothetical protein YQE_12103, partial [Dendroctonus ponderosae]>gi|546678633|gb|ERL89215.1| hypothetical protein D910_06589 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62471 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02402 Lysis protein GO:0009405//GO:0019835 pathogenesis//cytolysis -- -- GO:0019867 outer membrane -- -- Cluster-8309.62472 BF_2 65.85 1.04 2948 270007722 EFA04170.1 1689 2.7e-185 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TZZ7 877 1.6e-92 Extended synaptotagmin-2 OS=Mus musculus GN=Esyt2 PE=1 SV=1 PF00168//PF17047 C2 domain//Synaptotagmin-like mitochondrial-lipid-binding domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.62478 BF_2 2.00 1.98 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62479 BF_2 2.00 0.86 382 54042606 AAV28476.1 272 7.1e-22 arthrodial cuticle protein AMP8.1 [Callinectes sapidus] -- -- -- -- -- -- -- -- -- P81576 287 5.4e-25 Cuticle protein AM1159 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.62481 BF_2 6.00 0.64 680 676426134 XP_009044526.1 235 2.5e-17 hypothetical protein LOTGIDRAFT_109337, partial [Lottia gigantea]>gi|556116365|gb|ESP05017.1| hypothetical protein LOTGIDRAFT_109337, partial [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62483 BF_2 105.69 2.74 1902 546676744 ERL87700.1 844 1.7e-87 hypothetical protein D910_05090 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NBA8 407 3.3e-38 DTW domain-containing protein 2 OS=Homo sapiens GN=DTWD2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6249 BF_2 34.62 0.43 3687 642937648 XP_966362.2 1156 2.2e-123 PREDICTED: uncharacterized protein LOC654853 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VEE6 179 1.7e-11 Zinc finger protein 800 OS=Mus musculus GN=Znf800 PE=1 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.62517 BF_2 11.00 0.33 1676 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04277 Oxaloacetate decarboxylase, gamma chain GO:0006814//GO:0006090//GO:0071436//GO:0006525//GO:0006560 sodium ion transport//pyruvate metabolic process//sodium ion export//arginine metabolic process//proline metabolic process GO:0015081//GO:0008948 sodium ion transmembrane transporter activity//oxaloacetate decarboxylase activity GO:0016020 membrane -- -- Cluster-8309.62520 BF_2 65.00 2.17 1538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62527 BF_2 10.61 0.33 1639 270013873 EFA10321.1 870 1.4e-90 hypothetical protein TcasGA2_TC012537 [Tribolium castaneum] -- -- -- -- -- K08741 MSH5 DNA mismatch repair protein MSH5 http://www.genome.jp/dbget-bin/www_bget?ko:K08741 O43196 563 2.3e-56 MutS protein homolog 5 OS=Homo sapiens GN=MSH5 PE=1 SV=1 PF01637//PF00005//PF00488//PF03266//PF05192//PF00004 Archaeal ATPase//ABC transporter//MutS domain V//NTPase//MutS domain III//ATPase family associated with various cellular activities (AAA) GO:0006298 mismatch repair GO:0016887//GO:0030983//GO:0098519//GO:0005524 ATPase activity//mismatched DNA binding//nucleotide phosphatase activity, acting on free nucleotides//ATP binding -- -- KOG0221 Mismatch repair ATPase MSH5 (MutS family) Cluster-8309.62528 BF_2 8.00 8.22 317 -- -- -- -- -- 820703199 LN847492.1 317 7.86091e-164 TPA: Homo sapiens SCARNA10 gene for small nucleolar RNA SCARNA10 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62531 BF_2 47.11 1.01 2244 270001349 EEZ97796.1 874 6.6e-91 hypothetical protein TcasGA2_TC000158 [Tribolium castaneum] -- -- -- -- -- K06947 GRC3, NOL9 polynucleotide 5'-hydroxyl-kinase GRC3/NOL9 http://www.genome.jp/dbget-bin/www_bget?ko:K06947 A1ZA92 357 2.4e-32 Polynucleotide 5'-hydroxyl-kinase NOL9 OS=Drosophila melanogaster GN=CG8414 PE=2 SV=1 PF01580//PF00005 FtsK/SpoIIIE family//ABC transporter -- -- GO:0005524//GO:0000166//GO:0016887//GO:0003677 ATP binding//nucleotide binding//ATPase activity//DNA binding -- -- KOG2750 Uncharacterized conserved protein similar to ATP/GTP-binding protein Cluster-8309.62532 BF_2 4.00 0.43 674 86279291 ABC88741.1 302 4.2e-25 putative serine proteinase [Tenebrio molitor] -- -- -- -- -- K01311 CTRC chymotrypsin C http://www.genome.jp/dbget-bin/www_bget?ko:K01311 O97398 286 1.2e-24 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.62543 BF_2 3.00 1.75 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62548 BF_2 4.00 0.36 746 665796911 XP_008546264.1 248 8.5e-19 PREDICTED: dnaJ homolog subfamily B member 12 [Microplitis demolitor]>gi|607304256|gb|EZA45503.1| dnaJ subfamily B member 12-like protein [Microplitis demolitor] -- -- -- -- -- K09518 DNAJB12 DnaJ homolog subfamily B member 12 http://www.genome.jp/dbget-bin/www_bget?ko:K09518 Q9CZJ9 134 5.8e-07 DnaJ homolog subfamily C member 18 OS=Mus musculus GN=Dnajc18 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0714 Molecular chaperone (DnaJ superfamily) Cluster-8309.62549 BF_2 48.64 1.29 1861 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01344 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62553 BF_2 1.00 1.87 288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07926 TPR/MLP1/MLP2-like protein GO:0006606 protein import into nucleus -- -- -- -- -- -- Cluster-8309.62555 BF_2 51.57 6.33 628 91089491 XP_969723.1 538 1.7e-52 PREDICTED: U6 snRNA-associated Sm-like protein LSm7 [Tribolium castaneum] -- -- -- -- -- K12626 LSM7 U6 snRNA-associated Sm-like protein LSm7 http://www.genome.jp/dbget-bin/www_bget?ko:K12626 Q9UK45 433 1.0e-41 U6 snRNA-associated Sm-like protein LSm7 OS=Homo sapiens GN=LSM7 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1781 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.62556 BF_2 119.00 32.68 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62558 BF_2 61.87 2.30 1412 91089933 XP_967141.1 483 9.0e-46 PREDICTED: uncharacterized protein LOC661824 [Tribolium castaneum]>gi|270013546|gb|EFA09994.1| hypothetical protein TcasGA2_TC012161 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6256 BF_2 1.00 6.73 244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62561 BF_2 5.00 1.34 443 478257966 ENN78104.1 352 4.4e-31 hypothetical protein YQE_05258, partial [Dendroctonus ponderosae]>gi|546686101|gb|ERL95498.1| hypothetical protein D910_12760 [Dendroctonus ponderosae] -- -- -- -- -- K04819 HTR3 5-hydroxytryptamine receptor 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04819 P45963 178 2.7e-12 Acetylcholine receptor subunit alpha-type acr-7 OS=Caenorhabditis elegans GN=acr-7 PE=1 SV=2 PF02931 Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.62565 BF_2 19.00 3.90 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08086 Ergtoxin family GO:0006810//GO:0009405 transport//pathogenesis GO:0019870 potassium channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.62566 BF_2 82.90 1.47 2648 642926104 XP_008194786.1 555 7.6e-54 PREDICTED: uncharacterized protein LOC100141550 [Tribolium castaneum]>gi|270008534|gb|EFA04982.1| hypothetical protein TcasGA2_TC015060 [Tribolium castaneum] -- -- -- -- -- K12627 LSM8 U6 snRNA-associated Sm-like protein LSm8 http://www.genome.jp/dbget-bin/www_bget?ko:K12627 O95777 354 6.3e-32 U6 snRNA-associated Sm-like protein LSm8 OS=Homo sapiens GN=LSM8 PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1784 Small Nuclear ribonucleoprotein splicing factor Cluster-8309.62574 BF_2 1.42 0.55 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62580 BF_2 26.58 0.38 3252 642915789 XP_008200078.1 1770 1.2e-194 PREDICTED: uncharacterized protein LOC103314831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.62592 BF_2 1.00 0.48 372 270017193 EFA13639.1 177 7.2e-11 hypothetical protein TcasGA2_TC005208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62596 BF_2 4.00 0.33 797 270016062 EFA12510.1 378 7.6e-34 hypothetical protein TcasGA2_TC004208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 307 5.4e-27 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62600 BF_2 5.00 0.72 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62601 BF_2 5.00 0.49 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62608 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62616 BF_2 4.21 0.36 775 195160665 XP_002021195.1 360 9.1e-32 GL24941 [Drosophila persimilis]>gi|194118308|gb|EDW40351.1| GL24941 [Drosophila persimilis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62621 BF_2 96.33 2.28 2051 478257290 ENN77453.1 1543 1.6e-168 hypothetical protein YQE_06277, partial [Dendroctonus ponderosae] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q964R0 942 3.2e-100 Cytochrome P450 6k1 OS=Blattella germanica GN=CYP6K1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.6263 BF_2 16.88 0.51 1662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62637 BF_2 25.94 0.44 2773 642912936 XP_008201314.1 801 2.4e-82 PREDICTED: antichymotrypsin-2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P22922 535 6.8e-53 Antitrypsin OS=Bombyx mori PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62638 BF_2 4.00 0.69 531 820133310 KKX07404.1 204 7.6e-14 progestin and adipoQ receptor family member 6 isoform X3 [Scleropages formosus] -- -- -- -- -- -- -- -- -- Q6DC77 185 5.0e-13 Membrane progestin receptor gamma-B OS=Danio rerio GN=paqr5b PE=2 SV=1 PF03006 Haemolysin-III related -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.62641 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05365 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c -- -- GO:0005743//GO:0005750 mitochondrial inner membrane//mitochondrial respiratory chain complex III -- -- Cluster-8309.62656 BF_2 25.72 0.80 1634 546683322 ERL93149.1 255 2.9e-19 hypothetical protein D910_10448, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62666 BF_2 46.13 0.92 2389 270007206 EFA03654.1 2081 7.7e-231 hypothetical protein TcasGA2_TC013748 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q49B93 946 1.3e-100 Sodium-coupled monocarboxylate transporter 2 OS=Mus musculus GN=Slc5a12 PE=1 SV=1 PF09036//PF00474 Bcr-Abl oncoprotein oligomerisation domain//Sodium:solute symporter family GO:0055085//GO:0007165//GO:0006810//GO:0016310//GO:0009069//GO:0006468 transmembrane transport//signal transduction//transport//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005096//GO:0005215//GO:0004674 GTPase activator activity//transporter activity//protein serine/threonine kinase activity GO:0016020 membrane -- -- Cluster-8309.6267 BF_2 5.30 0.44 786 478251324 ENN71792.1 470 1.6e-44 hypothetical protein YQE_11526, partial [Dendroctonus ponderosae] -- -- -- -- -- K12590 RRP46, EXOSC5 exosome complex component RRP46 http://www.genome.jp/dbget-bin/www_bget?ko:K12590 Q9CRA8 253 9.6e-21 Exosome complex component RRP46 OS=Mus musculus GN=Exosc5 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG1069 Exosomal 3'-5' exoribonuclease complex, subunit Rrp46 Cluster-8309.62675 BF_2 1.00 0.81 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62681 BF_2 3.00 0.61 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62683 BF_2 13.95 1.01 866 91094103 XP_967297.1 897 5.5e-94 PREDICTED: trafficking protein particle complex subunit 13 [Tribolium castaneum]>gi|270010876|gb|EFA07324.1| hypothetical protein TcasGA2_TC015920 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0VFT9 644 4.9e-66 Trafficking protein particle complex subunit 13 OS=Xenopus tropicalis GN=trappc13 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2625 Uncharacterized conserved protein Cluster-8309.62694 BF_2 1.00 1.78 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6271 BF_2 4.00 1.14 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62721 BF_2 2.00 0.52 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62725 BF_2 1.00 0.52 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62730 BF_2 6.80 0.60 761 270003050 EEZ99497.1 344 6.4e-30 hypothetical protein TcasGA2_TC000073 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00098//PF01176//PF16588 Zinc knuckle//Translation initiation factor 1A / IF-1//C2H2 zinc-finger GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743//GO:0003676//GO:0008270//GO:0003723 translation initiation factor activity//nucleic acid binding//zinc ion binding//RNA binding GO:0005840 ribosome -- -- Cluster-8309.62733 BF_2 1.00 0.37 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62736 BF_2 16.00 0.34 2229 662212749 XP_008480126.1 167 6.3e-09 PREDICTED: uncharacterized protein LOC103516915 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06558 Secretion monitor precursor protein (SecM) -- -- GO:0045182 translation regulator activity -- -- -- -- Cluster-8309.62738 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62741 BF_2 43.61 1.80 1301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04433 SWIRM domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6275 BF_2 27.21 2.96 672 678195422 KFV62404.1 187 9.0e-12 hypothetical protein N307_01942, partial [Picoides pubescens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01299 Lysosome-associated membrane glycoprotein (Lamp) -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.62756 BF_2 16.59 0.37 2183 478253539 ENN73857.1 605 1.0e-59 hypothetical protein YQE_09549, partial [Dendroctonus ponderosae]>gi|546685411|gb|ERL94924.1| hypothetical protein D910_12196 [Dendroctonus ponderosae] -- -- -- -- -- K00273 DAO, aao D-amino-acid oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00273 Q99489 384 1.7e-35 D-aspartate oxidase OS=Homo sapiens GN=DDO PE=2 SV=1 PF07992//PF01266//PF00070 Pyridine nucleotide-disulphide oxidoreductase//FAD dependent oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- KOG3923 D-aspartate oxidase Cluster-8309.62790 BF_2 6.00 0.39 925 746836943 XP_011069200.1 212 1.6e-14 PREDICTED: uncharacterized protein LOC105155026 [Acromyrmex echinatior] 600831 U11649.1 121 2.22687e-54 MPU11649 Mantispa pulchella clone Mp1 mariner transposase pseudogene, complete cds -- -- -- -- -- -- -- -- PF12515 Ca2+-ATPase N terminal autoinhibitory domain -- -- GO:0005516 calmodulin binding -- -- -- -- Cluster-8309.62804 BF_2 8.00 0.31 1368 662195961 XP_008470989.1 139 6.8e-06 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62808 BF_2 91.75 2.72 1697 642923908 XP_008193923.1 505 3.0e-48 PREDICTED: polyglutamine-binding protein 1 [Tribolium castaneum]>gi|270007788|gb|EFA04236.1| hypothetical protein TcasGA2_TC014489 [Tribolium castaneum] -- -- -- -- -- K12865 PQBP1, NPW38 polyglutamine-binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K12865 Q2HJC9 185 1.6e-12 Polyglutamine-binding protein 1 OS=Bos taurus GN=PQBP1 PE=2 SV=1 PF02724//PF00397 CDC45-like protein//WW domain GO:0006270 DNA replication initiation GO:0005515 protein binding -- -- KOG3427 Polyglutamine tract-binding protein PQBP-1 Cluster-8309.62815 BF_2 103.00 11.56 660 570341946 AHE77371.1 354 3.8e-31 small heat shock protein [Lissorhoptrus oryzophilus] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P02516 200 1.1e-14 Heat shock protein 23 OS=Drosophila melanogaster GN=Hsp23 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62828 BF_2 6.69 0.91 596 642911589 XP_008200663.1 348 1.7e-30 PREDICTED: sodium/potassium-transporting ATPase subunit beta-1-interacting protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A6MHQ4 259 1.5e-21 Sodium/potassium-transporting ATPase subunit beta-1-interacting protein OS=Drosophila melanogaster GN=NKAIN PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.62829 BF_2 14.83 0.41 1801 546673768 ERL85319.1 1210 5.8e-130 hypothetical protein D910_02739 [Dendroctonus ponderosae] 462282558 APGK01057257.1 55 2.1571e-17 Dendroctonus ponderosae Seq01057267, whole genome shotgun sequence -- -- -- -- Q9D9I4 693 2.1e-71 TBC1 domain family member 20 OS=Mus musculus GN=Tbc1d20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2595 Predicted GTPase activator protein Cluster-8309.62843 BF_2 24.65 0.45 2577 546674262 ERL85681.1 1368 3.9e-148 hypothetical protein D910_03097 [Dendroctonus ponderosae] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q5U2Y6 854 6.5e-90 Tuftelin-interacting protein 11 OS=Rattus norvegicus GN=Tfip11 PE=2 SV=1 PF07842 GC-rich sequence DNA-binding factor-like protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005634 nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.62881 BF_2 137.00 1.80 3478 478257833 ENN77976.1 706 3.1e-71 hypothetical protein YQE_05652, partial [Dendroctonus ponderosae] -- -- -- -- -- K18665 NUDT8 nudix motif 8 http://www.genome.jp/dbget-bin/www_bget?ko:K18665 Q8WV74 264 2.3e-21 Nucleoside diphosphate-linked moiety X motif 8, mitochondrial OS=Homo sapiens GN=NUDT8 PE=2 SV=2 PF00293//PF07648//PF00050 NUDIX domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0016787//GO:0005515 hydrolase activity//protein binding -- -- KOG3069 Peroxisomal NUDIX hydrolase Cluster-8309.62891 BF_2 17.33 0.45 1904 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62899 BF_2 8.00 1.07 599 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62900 BF_2 8.86 0.56 946 91093355 XP_969078.1 531 1.6e-51 PREDICTED: WD repeat-containing protein 63 [Tribolium castaneum]>gi|270015301|gb|EFA11749.1| hypothetical protein TcasGA2_TC004239 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.62906 BF_2 3.00 0.33 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62907 BF_2 33.77 0.71 2263 642935762 XP_008198164.1 1462 4.4e-159 PREDICTED: uncharacterized protein C2orf42 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SYX3 691 4.5e-71 Uncharacterized protein C2orf42 homolog OS=Bos taurus PE=2 SV=1 PF06467 MYM-type Zinc finger with FCS sequence motif -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.62917 BF_2 9.89 0.42 1261 641666824 XP_008183865.1 568 1.1e-55 PREDICTED: uncharacterized protein LOC103309651 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q95SX7 386 5.9e-36 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF01691 Adenovirus E1B 19K protein / small t-antigen GO:0043066 negative regulation of apoptotic process GO:0005521 lamin binding -- -- -- -- Cluster-8309.62926 BF_2 4.74 1.06 474 642930454 XP_008196409.1 155 3.3e-08 PREDICTED: ribonuclease P protein subunit rpr2-like [Tribolium castaneum]>gi|642930456|ref|XP_008196410.1| PREDICTED: ribonuclease P protein subunit rpr2-like [Tribolium castaneum]>gi|642930458|ref|XP_008196411.1| PREDICTED: ribonuclease P protein subunit rpr2-like [Tribolium castaneum]>gi|642930460|ref|XP_008196412.1| PREDICTED: ribonuclease P protein subunit rpr2-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62927 BF_2 30.97 0.88 1766 270015507 EFA11955.1 512 4.9e-49 hypothetical protein TcasGA2_TC008556 [Tribolium castaneum] -- -- -- -- -- K03504 POLD3 DNA polymerase delta subunit 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03504 Q9EQ28 188 7.5e-13 DNA polymerase delta subunit 3 OS=Mus musculus GN=Pold3 PE=1 SV=2 PF09507//PF08689//PF00538 DNA polymerase subunit Cdc27//Mediator complex subunit Med5//linker histone H1 and H5 family GO:0006334//GO:0006260//GO:0006357 nucleosome assembly//DNA replication//regulation of transcription from RNA polymerase II promoter GO:0003677//GO:0001104 DNA binding//RNA polymerase II transcription cofactor activity GO:0000786//GO:0005634//GO:0016592 nucleosome//nucleus//mediator complex -- -- Cluster-8309.62928 BF_2 9.58 0.62 934 642939840 XP_008193774.1 226 3.8e-16 PREDICTED: DNA polymerase delta subunit 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06390 Neuroendocrine-specific golgi protein P55 (NESP55) GO:0071107 response to parathyroid hormone -- -- -- -- -- -- Cluster-8309.62936 BF_2 2.00 0.82 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62942 BF_2 1.00 1.29 305 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62958 BF_2 88.44 2.83 1593 270000766 EEZ97213.1 1295 7.1e-140 hypothetical protein TcasGA2_TC011005 [Tribolium castaneum] -- -- -- -- -- K18403 MSL3 male-specific lethal 3 http://www.genome.jp/dbget-bin/www_bget?ko:K18403 Q5R6Y9 507 6.9e-50 Male-specific lethal 3 homolog OS=Pongo abelii GN=MSL3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3001 Dosage compensation regulatory complex/histone acetyltransferase complex, subunit MSL-3/MRG15/EAF3, and related CHROMO domain-containing proteins Cluster-8309.62960 BF_2 17.05 1.20 883 478263495 ENN81850.1 314 2.2e-26 hypothetical protein YQE_01788, partial [Dendroctonus ponderosae]>gi|546685498|gb|ERL94996.1| hypothetical protein D910_12268 [Dendroctonus ponderosae] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9UKD2 246 7.0e-20 mRNA turnover protein 4 homolog OS=Homo sapiens GN=MRTO4 PE=1 SV=2 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.62977 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.62991 BF_2 15.00 0.43 1734 49119653 AAH73141.1 1174 8.3e-126 YWHAZ protein, partial [Homo sapiens] 767953585 XM_005251062.2 1629 0 PREDICTED: Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta (YWHAZ), transcript variant X2, mRNA K16197 YWHAB_Q_Z 14-3-3 protein beta/theta/zeta http://www.genome.jp/dbget-bin/www_bget?ko:K16197 P63103 1170 9.9e-127 14-3-3 protein zeta/delta OS=Bos taurus GN=YWHAZ PE=1 SV=1 PF02154//PF15499//PF11808 Flagellar motor switch protein FliM//Ubiquitin-specific peptidase-like, SUMO isopeptidase//Domain of unknown function (DUF3329) GO:0016310//GO:0071973 phosphorylation//bacterial-type flagellum-dependent cell motility GO:0003774//GO:0004673//GO:0032183//GO:0070140 motor activity//protein histidine kinase activity//SUMO binding//SUMO-specific isopeptidase activity GO:0009425//GO:0009365 bacterial-type flagellum basal body//protein histidine kinase complex -- -- Cluster-8309.62999 BF_2 137.68 1.98 3201 642910641 XP_008200040.1 2512 1.1e-280 PREDICTED: FERM domain-containing protein 5 [Tribolium castaneum]>gi|270014529|gb|EFA10977.1| hypothetical protein TcasGA2_TC004143 [Tribolium castaneum] 642910640 XM_008201818.1 545 0 PREDICTED: Tribolium castaneum FERM domain-containing protein 5 (LOC656473), mRNA -- -- -- -- Q7Z6J6 787 4.7e-82 FERM domain-containing protein 5 OS=Homo sapiens GN=FRMD5 PE=1 SV=1 PF15168 Triple QxxK/R motif-containing protein family -- -- GO:0008092 cytoskeletal protein binding GO:0005789//GO:0005856//GO:0019898//GO:0005737 endoplasmic reticulum membrane//cytoskeleton//extrinsic component of membrane//cytoplasm KOG3530 FERM domain protein EHM2 Cluster-8309.63 BF_2 3.00 0.34 655 410446425 AFV69126.1 537 2.3e-52 mitochondrial cytochrome c oxidase subunit Vb [Litopenaeus vannamei] -- -- -- -- -- K02265 COX5B cytochrome c oxidase subunit 5b http://www.genome.jp/dbget-bin/www_bget?ko:K02265 P00428 208 1.3e-15 Cytochrome c oxidase subunit 5B, mitochondrial OS=Bos taurus GN=COX5B PE=1 SV=2 PF01215 Cytochrome c oxidase subunit Vb GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277//GO:0005740 respiratory chain complex IV//mitochondrial envelope KOG3352 Cytochrome c oxidase, subunit Vb/COX4 Cluster-8309.6300 BF_2 10.00 0.43 1249 270004703 EFA01151.1 754 3.0e-77 hypothetical protein TcasGA2_TC010376 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9EQZ7 192 1.8e-13 Regulating synaptic membrane exocytosis protein 2 OS=Mus musculus GN=Rims2 PE=1 SV=1 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63003 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63009 BF_2 2.00 0.56 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63027 BF_2 8.00 0.55 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07966 A1 Propeptide GO:0006508 proteolysis GO:0004190 aspartic-type endopeptidase activity -- -- -- -- Cluster-8309.6303 BF_2 21.00 0.47 2165 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63032 BF_2 5.00 0.50 704 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF09726//PF00957//PF05843 Transmembrane protein//Synaptobrevin//Suppressor of forked protein (Suf) GO:0016192//GO:0006397 vesicle-mediated transport//mRNA processing -- -- GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.63045 BF_2 17.97 0.42 2070 830120960 XP_012585728.1 299 2.9e-24 PREDICTED: zinc finger protein 41 [Condylura cristata] -- -- -- -- -- -- -- -- -- Q06730 291 1.0e-24 Zinc finger protein 33A OS=Homo sapiens GN=ZNF33A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63053 BF_2 26.29 0.39 3084 642935223 XP_008199698.1 2123 1.3e-235 PREDICTED: uncharacterized protein LOC103314735 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58CV6 236 3.5e-18 Kelch domain-containing protein 3 OS=Bos taurus GN=KLHDC3 PE=2 SV=2 PF07646//PF01239//PF01344 Kelch motif//Protein prenyltransferase alpha subunit repeat//Kelch motif GO:0018342 protein prenylation GO:0005515//GO:0008318 protein binding//protein prenyltransferase activity -- -- -- -- Cluster-8309.63069 BF_2 16.74 0.42 1966 91079971 XP_969899.1 654 1.9e-65 PREDICTED: beta-1,3-galactosyltransferase 5 [Tribolium castaneum]>gi|270004606|gb|EFA01054.1| hypothetical protein TcasGA2_TC003970 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9N293 325 1.1e-28 Beta-1,3-galactosyltransferase 5 (Fragment) OS=Gorilla gorilla gorilla GN=B3GALT5 PE=3 SV=2 PF01762//PF02434 Galactosyltransferase//Fringe-like GO:0006486 protein glycosylation GO:0008378//GO:0016757 galactosyltransferase activity//transferase activity, transferring glycosyl groups GO:0016020 membrane -- -- Cluster-8309.63071 BF_2 20.69 0.88 1267 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6308 BF_2 1.02 0.36 405 642922284 XP_008193093.1 376 6.6e-34 PREDICTED: extracellular sulfatase SULF-1 homolog isoform X3 [Tribolium castaneum] -- -- -- -- -- K14607 SULF extracellular sulfatase Sulf http://www.genome.jp/dbget-bin/www_bget?ko:K14607 Q9VEX0 298 3.0e-26 Extracellular sulfatase SULF-1 homolog OS=Drosophila melanogaster GN=Sulf1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG3731 Sulfatases Cluster-8309.63080 BF_2 26.45 0.36 3357 478260698 ENN80386.1 1173 2.1e-125 hypothetical protein YQE_03188, partial [Dendroctonus ponderosae] -- -- -- -- -- K10398 KIF11, EG5 kinesin family member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K10398 P46863 1043 1.0e-111 Bipolar kinesin KRP-130 OS=Drosophila melanogaster GN=Klp61F PE=1 SV=2 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0005524//GO:0008017//GO:0003777 ATP binding//microtubule binding//microtubule motor activity GO:0005874//GO:0045298 microtubule//tubulin complex KOG0243 Kinesin-like protein Cluster-8309.63101 BF_2 2.49 0.35 588 189234531 XP_967948.2 203 1.1e-13 PREDICTED: bumetanide-sensitive sodium-(potassium)-chloride cotransporter [Tribolium castaneum]>gi|270001701|gb|EEZ98148.1| hypothetical protein TcasGA2_TC000573 [Tribolium castaneum] -- -- -- -- -- K10951 SLC12A2, NKCC1 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K10951 Q25479 179 2.7e-12 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter OS=Manduca sexta PE=2 SV=1 PF03522 Solute carrier family 12 GO:0055085//GO:0006821//GO:0006810//GO:0006812//GO:0006811 transmembrane transport//chloride transport//transport//cation transport//ion transport GO:0005215//GO:0015377 transporter activity//cation:chloride symporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG2083 Na+/K+ symporter Cluster-8309.63102 BF_2 6.12 0.64 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63105 BF_2 4.00 0.46 654 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63107 BF_2 26.00 1.21 1184 641651338 XP_003241056.2 738 2.0e-75 PREDICTED: uncharacterized protein LOC100574409 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858 Amiloride-sensitive sodium channel GO:0006814 sodium ion transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.63108 BF_2 26.18 0.92 1475 641660547 XP_008181531.1 557 2.5e-54 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- -- -- Cluster-8309.63111 BF_2 8.00 0.75 734 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03824 High-affinity nickel-transport protein GO:0035444//GO:0015675 nickel cation transmembrane transport//nickel cation transport GO:0015099//GO:0046872 nickel cation transmembrane transporter activity//metal ion binding GO:0016021 integral component of membrane -- -- Cluster-8309.63117 BF_2 41.25 0.49 3845 662195961 XP_008470989.1 905 2.9e-94 PREDICTED: uncharacterized protein LOC103508236 [Diaphorina citri] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63129 BF_2 3.00 0.65 481 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63133 BF_2 12.51 0.35 1799 676782267 KFP08573.1 154 1.6e-07 hypothetical protein N300_11781, partial [Calypte anna] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63134 BF_2 103.83 4.10 1346 157133236 XP_001656193.1 341 2.5e-29 AAEL012688-PA [Aedes aegypti]>gi|108870898|gb|EAT35123.1| AAEL012688-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63137 BF_2 29.62 0.31 4252 642935895 XP_008198218.1 1446 5.9e-157 PREDICTED: poly(A)-specific ribonuclease PARN-like domain-containing protein 1 isoform X1 [Tribolium castaneum]>gi|270013255|gb|EFA09703.1| hypothetical protein TcasGA2_TC011836 [Tribolium castaneum] 688627348 LL261331.1 76 1.09096e-28 Echinostoma caproni genome assembly E_caproni_Egypt ,scaffold ECPE_scaffold0027233 K01148 PARN poly(A)-specific ribonuclease http://www.genome.jp/dbget-bin/www_bget?ko:K01148 Q8NA58 520 5.7e-51 Poly(A)-specific ribonuclease PARN-like domain-containing protein 1 OS=Homo sapiens GN=PNLDC1 PE=2 SV=2 PF04857 CAF1 family ribonuclease -- -- -- -- GO:0005634 nucleus KOG1990 Poly(A)-specific exoribonuclease PARN Cluster-8309.63139 BF_2 3.63 0.87 461 157105009 XP_001648674.1 157 1.9e-08 AAEL000581-PA [Aedes aegypti]>gi|108884166|gb|EAT48391.1| AAEL000581-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- P97608 149 6.5e-09 5-oxoprolinase OS=Rattus norvegicus GN=Oplah PE=1 SV=2 PF02538 Hydantoinase B/oxoprolinase -- -- GO:0003824 catalytic activity -- -- -- -- Cluster-8309.63151 BF_2 1.00 0.45 379 642915648 XP_008190695.1 316 5.6e-27 PREDICTED: uncharacterized protein LOC103312267 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63163 BF_2 2.00 0.58 431 170035381 XP_001845548.1 167 1.2e-09 chloride channel protein 2 [Culex quinquefasciatus]>gi|167877364|gb|EDS40747.1| chloride channel protein 2 [Culex quinquefasciatus] -- -- -- -- -- -- -- -- -- Q9VGH7 134 3.3e-07 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63164 BF_2 30.00 0.45 3066 270008907 EFA05355.1 1781 6.0e-196 hypothetical protein TcasGA2_TC015520 [Tribolium castaneum] -- -- -- -- -- K05011 CLCN2 chloride channel 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05011 Q9VGH7 1698 1.0e-187 Chloride channel protein 2 OS=Drosophila melanogaster GN=ClC-a PE=2 SV=3 PF00654//PF09514 Voltage gated chloride channel//SSXRD motif GO:0006821//GO:0006355//GO:0055085 chloride transport//regulation of transcription, DNA-templated//transmembrane transport GO:0005247 voltage-gated chloride channel activity GO:0005634//GO:0016020 nucleus//membrane KOG0476 Cl- channel CLC-2 and related proteins (CLC superfamily) Cluster-8309.63168 BF_2 8.00 0.31 1361 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63175 BF_2 4.00 0.43 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63182 BF_2 10.84 0.31 1745 91077324 XP_974759.1 577 1.4e-56 PREDICTED: pyrroline-5-carboxylate reductase [Tribolium castaneum]>gi|270001669|gb|EEZ98116.1| hypothetical protein TcasGA2_TC000534 [Tribolium castaneum] -- -- -- -- -- K00286 proC pyrroline-5-carboxylate reductase http://www.genome.jp/dbget-bin/www_bget?ko:K00286 P17817 350 1.2e-31 Pyrroline-5-carboxylate reductase OS=Glycine max PE=2 SV=1 PF00479//PF01210//PF03446 Glucose-6-phosphate dehydrogenase, NAD binding domain//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus//NAD binding domain of 6-phosphogluconate dehydrogenase GO:0006098//GO:0006525//GO:0046168//GO:0006749//GO:0006006//GO:0006561//GO:0019521//GO:0055114 pentose-phosphate shunt//arginine metabolic process//glycerol-3-phosphate catabolic process//glutathione metabolic process//glucose metabolic process//proline biosynthetic process//D-gluconate metabolic process//oxidation-reduction process GO:0004735//GO:0050661//GO:0016616//GO:0051287//GO:0000166//GO:0004616//GO:0004345 pyrroline-5-carboxylate reductase activity//NADP binding//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//nucleotide binding//phosphogluconate dehydrogenase (decarboxylating) activity//glucose-6-phosphate dehydrogenase activity -- -- KOG3124 Pyrroline-5-carboxylate reductase Cluster-8309.6319 BF_2 12.94 0.53 1317 270015016 EFA11464.1 874 3.9e-91 hypothetical protein TcasGA2_TC014173 [Tribolium castaneum] -- -- -- -- -- K11323 JMJD6 histone arginine demethylase JMJD6 http://www.genome.jp/dbget-bin/www_bget?ko:K11323 Q9VD28 750 3.8e-78 Bifunctional arginine demethylase and lysyl-hydroxylase PSR OS=Drosophila melanogaster GN=PSR PE=2 SV=1 PF11734 TilS substrate C-terminal domain GO:0008033 tRNA processing GO:0016879//GO:0000166//GO:0005524 ligase activity, forming carbon-nitrogen bonds//nucleotide binding//ATP binding GO:0005737 cytoplasm KOG2130 Phosphatidylserine-specific receptor PtdSerR, contains JmjC domain Cluster-8309.63192 BF_2 86.73 1.61 2546 642926658 XP_008194957.1 259 1.5e-19 PREDICTED: uncharacterized protein LOC103313445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF02899//PF07544//PF09429 THAP domain//Phage integrase, N-terminal SAM-like domain//RNA polymerase II transcription mediator complex subunit 9//WW domain binding protein 11 GO:0006396//GO:0015074//GO:0006357 RNA processing//DNA integration//regulation of transcription from RNA polymerase II promoter GO:0003677//GO:0001104//GO:0003676 DNA binding//RNA polymerase II transcription cofactor activity//nucleic acid binding GO:0016592 mediator complex -- -- Cluster-8309.63193 BF_2 21.87 0.43 2415 642926658 XP_008194957.1 259 1.5e-19 PREDICTED: uncharacterized protein LOC103313445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6ZMV9 184 3.0e-12 Kinesin-like protein KIF6 OS=Homo sapiens GN=KIF6 PE=1 SV=3 PF07544 RNA polymerase II transcription mediator complex subunit 9 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex -- -- Cluster-8309.63194 BF_2 22.33 0.37 2837 642926658 XP_008194957.1 259 1.7e-19 PREDICTED: uncharacterized protein LOC103313445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF09429//PF07544//PF02899//PF05485 WW domain binding protein 11//RNA polymerase II transcription mediator complex subunit 9//Phage integrase, N-terminal SAM-like domain//THAP domain GO:0006357//GO:0015074//GO:0006396 regulation of transcription from RNA polymerase II promoter//DNA integration//RNA processing GO:0003677//GO:0001104//GO:0003676 DNA binding//RNA polymerase II transcription cofactor activity//nucleic acid binding GO:0016592 mediator complex -- -- Cluster-8309.63214 BF_2 61.13 0.42 6340 642919021 XP_008191699.1 1761 2.6e-193 PREDICTED: centrosomal protein of 164 kDa isoform X1 [Tribolium castaneum]>gi|270005603|gb|EFA02051.1| hypothetical protein TcasGA2_TC007679 [Tribolium castaneum] -- -- -- -- -- K16462 CEP164 centrosomal protein CEP164 http://www.genome.jp/dbget-bin/www_bget?ko:K16462 Q5DU05 178 3.9e-11 Centrosomal protein of 164 kDa OS=Mus musculus GN=Cep164 PE=2 SV=2 PF00397 WW domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63216 BF_2 9.45 0.74 822 546674391 ERL85778.1 215 6.2e-15 hypothetical protein D910_03193 [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q505G8 162 3.6e-10 Zinc finger protein 827 OS=Mus musculus GN=Znf827 PE=2 SV=2 PF13465//PF00096 Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.63221 BF_2 16.00 0.97 979 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08395//PF03839//PF06151 7tm Chemosensory receptor//Translocation protein Sec62//Trehalose receptor GO:0050909//GO:0050912//GO:0015031//GO:0007187//GO:0007607 sensory perception of taste//detection of chemical stimulus involved in sensory perception of taste//protein transport//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//obsolete taste perception GO:0008565//GO:0008527 protein transporter activity//taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.63224 BF_2 1.00 0.42 386 642938945 XP_008200098.1 167 1.1e-09 PREDICTED: probable cytochrome P450 6a23, partial [Tribolium castaneum]>gi|270016185|gb|EFA12633.1| cytochrome P450 6BK5, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95031 131 6.6e-07 Cytochrome P450 6B6 OS=Helicoverpa armigera GN=CYP6B6 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.63232 BF_2 5.29 0.31 995 546684931 ERL94513.1 484 4.9e-46 hypothetical protein D910_11790 [Dendroctonus ponderosae] -- -- -- -- -- K17429 MRPL48 large subunit ribosomal protein L48 http://www.genome.jp/dbget-bin/www_bget?ko:K17429 Q2YDI5 203 7.7e-15 39S ribosomal protein L48, mitochondrial OS=Bos taurus GN=MRPL48 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4060 Uncharacterized conserved protein Cluster-8309.63235 BF_2 4.00 0.35 768 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63242 BF_2 39.66 0.42 4265 478253248 ENN73619.1 690 2.7e-69 hypothetical protein YQE_09866, partial [Dendroctonus ponderosae] -- -- -- -- -- K15277 SLC35B3, PAPST2 solute carrier family 35 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3 http://www.genome.jp/dbget-bin/www_bget?ko:K15277 Q7Q5D4 522 3.4e-51 Adenosine 3'-phospho 5'-phosphosulfate transporter 2 OS=Anopheles gambiae GN=Papst2 PE=3 SV=4 PF00892//PF08449 EamA-like transporter family//UAA transporter family GO:0055085 transmembrane transport -- -- GO:0016020//GO:0016021 membrane//integral component of membrane KOG1582 UDP-galactose transporter related protein Cluster-8309.63244 BF_2 2.00 0.40 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63258 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63261 BF_2 76.89 3.66 1167 478259272 ENN79174.1 642 2.7e-64 hypothetical protein YQE_04358, partial [Dendroctonus ponderosae] -- -- -- -- -- K14452 LIPF gastric triacylglycerol lipase http://www.genome.jp/dbget-bin/www_bget?ko:K14452 Q5VXJ0 397 2.9e-37 Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.63262 BF_2 20.22 3.27 546 546675022 ERL86285.1 301 4.4e-25 hypothetical protein D910_03694 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5VXJ0 143 3.8e-08 Lipase member K OS=Homo sapiens GN=LIPK PE=2 SV=2 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.63268 BF_2 4.00 0.46 652 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63279 BF_2 4.00 0.85 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6328 BF_2 1.00 1.11 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63288 BF_2 201.45 2.23 4068 546676034 ERL87120.1 642 9.5e-64 hypothetical protein D910_04520, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RE88 381 7.2e-35 WD repeat-containing protein 66 OS=Pongo abelii GN=WDR66 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63289 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01429 Methyl-CpG binding domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.63301 BF_2 39.00 8.96 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63305 BF_2 30.00 0.34 3935 -- -- -- -- -- 462283145 APGK01057037.1 45 1.72451e-11 Dendroctonus ponderosae Seq01057047, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63309 BF_2 1.00 0.36 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63316 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63318 BF_2 5.52 0.53 726 642917897 XP_008191374.1 249 6.3e-19 PREDICTED: nuclear hormone receptor FTZ-F1 isoform X2 [Tribolium castaneum] 642917898 XM_008193153.1 141 1.31821e-65 PREDICTED: Tribolium castaneum nuclear hormone receptor FTZ-F1 (LOC658929), transcript variant X3, mRNA K08705 NR5A3, ftz-f1 nuclear receptor subfamily 5 group A member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K08705 P49867 205 3.3e-15 Nuclear hormone receptor FTZ-F1 OS=Bombyx mori GN=FTZ-F1 PE=1 SV=2 PF00288 GHMP kinases N terminal domain -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8309.63321 BF_2 15.76 0.37 2051 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15150 Phorbol-12-myristate-13-acetate-induced GO:0006919//GO:0006974//GO:0001836//GO:0006915 activation of cysteine-type endopeptidase activity involved in apoptotic process//cellular response to DNA damage stimulus//release of cytochrome c from mitochondria//apoptotic process -- -- -- -- -- -- Cluster-8309.63328 BF_2 3.00 2.33 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63349 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63359 BF_2 53.54 5.51 694 546681961 ERL91957.1 493 3.1e-47 hypothetical protein D910_09280 [Dendroctonus ponderosae] -- -- -- -- -- K11667 INO80C, IES6 INO80 complex subunit C http://www.genome.jp/dbget-bin/www_bget?ko:K11667 Q6PI98 282 3.7e-24 INO80 complex subunit C OS=Homo sapiens GN=INO80C PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4137 Uncharacterized conserved protein Cluster-8309.63394 BF_2 5.57 0.31 1034 478256643 ENN76825.1 205 1.1e-13 hypothetical protein YQE_06666, partial [Dendroctonus ponderosae]>gi|546685158|gb|ERL94685.1| hypothetical protein D910_11960 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8N3L3 145 4.2e-08 Beta-taxilin OS=Homo sapiens GN=TXLNB PE=1 SV=3 PF00548//PF09728 3C cysteine protease (picornain 3C)//Myosin-like coiled-coil protein GO:0006508 proteolysis GO:0019905//GO:0004197 syntaxin binding//cysteine-type endopeptidase activity -- -- -- -- Cluster-8309.634 BF_2 1.00 0.45 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63403 BF_2 21.12 0.32 3072 270015547 EFA11995.1 1435 8.0e-156 hypothetical protein TcasGA2_TC005145 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95SX7 398 5.8e-37 Probable RNA-directed DNA polymerase from transposon BS OS=Drosophila melanogaster GN=RTase PE=2 SV=1 PF08172 CASP C terminal GO:0006891 intra-Golgi vesicle-mediated transport -- -- GO:0030173 integral component of Golgi membrane -- -- Cluster-8309.63409 BF_2 285.82 4.78 2791 646716704 KDR19844.1 661 4.1e-66 hypothetical protein L798_05910 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- Q9W440 592 1.7e-59 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 PF08168 NUC205 domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.63421 BF_2 11.96 0.41 1511 332374592 AEE62437.1 541 1.8e-52 unknown [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 331 1.7e-29 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.63429 BF_2 2.00 2.80 301 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63431 BF_2 67.27 1.02 3045 270007722 EFA04170.1 884 6.2e-92 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5FWL4 476 5.2e-46 Extended synaptotagmin-2-A OS=Xenopus laevis GN=esyt2-a PE=2 SV=1 PF17047//PF00168 Synaptotagmin-like mitochondrial-lipid-binding domain//C2 domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.63437 BF_2 38.00 0.92 2021 642932281 XP_008197046.1 172 1.5e-09 PREDICTED: uncharacterized protein LOC103314045 [Tribolium castaneum]>gi|270011627|gb|EFA08075.1| hypothetical protein TcasGA2_TC005671 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF16752 Tubulin-specific chaperone C N-terminal domain -- -- GO:0015631 tubulin binding GO:0045298 tubulin complex -- -- Cluster-8309.63445 BF_2 71.47 0.43 7292 270014787 EFA11235.1 3899 0.0e+00 hypothetical protein TcasGA2_TC010767 [Tribolium castaneum] 642911510 XM_008201231.1 266 4.4977e-134 PREDICTED: Tribolium castaneum protein unc-79 homolog (LOC662785), mRNA -- -- -- -- Q9P2D8 1364 1.3e-148 Protein unc-79 homolog OS=Homo sapiens GN=UNC79 PE=2 SV=4 PF08689 Mediator complex subunit Med5 GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0001104 RNA polymerase II transcription cofactor activity GO:0016592 mediator complex KOG4820 Involved in anesthetic response in C.elegans Cluster-8309.63447 BF_2 3.00 1.24 387 669214689 CDW61247.1 204 5.5e-14 Cell wall-associated hydrolase [Trichuris trichiura] 529308513 KC677617.1 318 2.72434e-164 Bradyrhizobium sp. OHSU_III 16 ribosomal RNA, tRNA-Ile, tRNA-Ala, 23S ribosomal RNA, and 5S ribosomal RNA genes, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63453 BF_2 3.00 0.33 666 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63460 BF_2 4.00 0.56 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63461 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63479 BF_2 16.25 0.50 1649 478250357 ENN70854.1 157 6.7e-08 hypothetical protein YQE_12517, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63491 BF_2 7.00 0.54 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6350 BF_2 19.61 0.63 1588 478257001 ENN77165.1 586 1.2e-57 hypothetical protein YQE_06304, partial [Dendroctonus ponderosae]>gi|546675571|gb|ERL86740.1| hypothetical protein D910_04146 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q3UJZ3 330 2.3e-29 Armadillo repeat-containing protein 7 OS=Mus musculus GN=Armc7 PE=2 SV=2 PF01245//PF00514//PF01157 Ribosomal protein L19//Armadillo/beta-catenin-like repeat//Ribosomal protein L21e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG4646 Uncharacterized conserved protein, contains ARM repeats Cluster-8309.6351 BF_2 6.00 0.44 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63510 BF_2 61.00 4.45 860 91086635 XP_966565.1 612 6.0e-61 PREDICTED: U11/U12 small nuclear ribonucleoprotein 35 kDa protein [Tribolium castaneum]>gi|270009757|gb|EFA06205.1| hypothetical protein TcasGA2_TC009054 [Tribolium castaneum] -- -- -- -- -- K13155 SNRNP35 U11/U12 small nuclear ribonucleoprotein 35 kDa protein http://www.genome.jp/dbget-bin/www_bget?ko:K13155 Q05AT9 442 1.3e-42 U11/U12 small nuclear ribonucleoprotein 35 kDa protein OS=Xenopus laevis GN=snrnp35 PE=2 SV=1 PF00076//PF16367 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//RNA recognition motif -- -- GO:0097159//GO:0003676//GO:1901363 organic cyclic compound binding//nucleic acid binding//heterocyclic compound binding -- -- KOG0113 U1 small nuclear ribonucleoprotein (RRM superfamily) Cluster-8309.63511 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63514 BF_2 38.00 1.55 1314 478258102 ENN78240.1 450 5.6e-42 hypothetical protein YQE_05391, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.63529 BF_2 22.92 5.18 472 642937855 XP_008200328.1 205 5.2e-14 PREDICTED: protein TEX261 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6UWH6 145 1.9e-08 Protein TEX261 OS=Homo sapiens GN=TEX261 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63545 BF_2 20.62 0.38 2528 765152853 XP_011486652.1 633 6.5e-63 PREDICTED: putative nuclease HARBI1 [Oryzias latipes] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944//PF00453 BESS motif//Ribosomal protein L20 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003677//GO:0019843//GO:0003735 DNA binding//rRNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome -- -- Cluster-8309.63551 BF_2 2.00 0.55 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63556 BF_2 3.00 0.39 613 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63558 BF_2 41.55 0.46 4091 751234819 XP_011171162.1 407 1.7e-36 PREDICTED: uncharacterized protein LOC105203928 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05125//PF05485 Phage major capsid protein, P2 family//THAP domain -- -- GO:0003676 nucleic acid binding GO:0019028 viral capsid -- -- Cluster-8309.6356 BF_2 63.71 0.37 7411 642921556 XP_008192422.1 4149 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9JLB4 2087 2.0e-232 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 -- -- -- -- -- -- -- -- KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.6357 BF_2 1.00 0.50 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63584 BF_2 37.14 0.34 4858 91085743 XP_973670.1 2576 6.2e-288 PREDICTED: Fanconi anemia group M protein homolog [Tribolium castaneum] 884966605 XM_013137615.1 65 1.62555e-22 PREDICTED: Esox lucius Fanconi anemia, complementation group M (fancm), mRNA K10896 FANCM fanconi anemia group M protein http://www.genome.jp/dbget-bin/www_bget?ko:K10896 Q8IYD8 1231 2.3e-133 Fanconi anemia group M protein OS=Homo sapiens GN=FANCM PE=1 SV=2 PF04851//PF00270 Type III restriction enzyme, res subunit//DEAD/DEAH box helicase -- -- GO:0003676//GO:0003677//GO:0016787//GO:0005524 nucleic acid binding//DNA binding//hydrolase activity//ATP binding -- -- KOG0354 DEAD-box like helicase Cluster-8309.63593 BF_2 25.19 0.47 2551 478263509 ENN81862.1 759 1.6e-77 hypothetical protein YQE_01754, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF02601//PF04871 Outer membrane protein (OmpH-like)//Exonuclease VII, large subunit//Uso1 / p115 like vesicle tethering protein, C terminal region GO:0006308//GO:0015031//GO:0006886 DNA catabolic process//protein transport//intracellular protein transport GO:0051082//GO:0008565//GO:0008855 unfolded protein binding//protein transporter activity//exodeoxyribonuclease VII activity GO:0009318//GO:0016020//GO:0005737 exodeoxyribonuclease VII complex//membrane//cytoplasm -- -- Cluster-8309.63601 BF_2 12.78 0.51 1332 291170322 ADD82417.1 300 1.4e-24 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27018 136 6.0e-07 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.63602 BF_2 15.91 0.79 1134 291170322 ADD82417.1 298 2.1e-24 minus-C odorant binding protein 4 [Batocera horsfieldi] -- -- -- -- -- -- -- -- -- Q27018 126 7.4e-06 B2 protein (Fragment) OS=Tenebrio molitor PE=2 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.63627 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63631 BF_2 29.20 0.74 1937 642913527 XP_008201051.1 439 1.6e-40 PREDICTED: protein timeless homolog [Tribolium castaneum]>gi|270002773|gb|EEZ99220.1| timeout [Tribolium castaneum] -- -- -- -- -- K03155 TIMELESS timeless http://www.genome.jp/dbget-bin/www_bget?ko:K03155 Q9R1X4 210 2.3e-15 Protein timeless homolog OS=Mus musculus GN=Timeless PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1974 DNA topoisomerase I-interacting protein Cluster-8309.63636 BF_2 9.48 0.34 1457 829834995 XP_012634098.1 631 6.4e-63 PREDICTED: zinc finger MYM-type protein 2 isoform X2 [Microcebus murinus] -- -- -- -- -- -- -- -- -- Q96DM1 282 7.8e-24 PiggyBac transposable element-derived protein 4 OS=Homo sapiens GN=PGBD4 PE=2 SV=3 PF07975//PF01428 TFIIH C1-like domain//AN1-like Zinc finger GO:0006281 DNA repair GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.63647 BF_2 24.10 0.58 2031 195115427 XP_002002258.1 290 3.1e-23 GI17285 [Drosophila mojavensis]>gi|193912833|gb|EDW11700.1| GI17285 [Drosophila mojavensis] -- -- -- -- -- K00252 GCDH, gcdH glutaryl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00252 Q2KHZ9 263 1.7e-21 Glutaryl-CoA dehydrogenase, mitochondrial OS=Bos taurus GN=GCDH PE=2 SV=1 PF12539//PF09229//PF00441 Chromosome segregation protein Csm1/Pcs1//Activator of Hsp90 ATPase, N-terminal//Acyl-CoA dehydrogenase, C-terminal domain GO:0055114 oxidation-reduction process GO:0016491//GO:0005515//GO:0016627//GO:0001671//GO:0051087 oxidoreductase activity//protein binding//oxidoreductase activity, acting on the CH-CH group of donors//ATPase activator activity//chaperone binding -- -- KOG0138 Glutaryl-CoA dehydrogenase Cluster-8309.63664 BF_2 4.00 1.06 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63675 BF_2 47.94 1.23 1917 478266751 ENN82895.1 268 1.0e-20 hypothetical protein YQE_00735, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63680 BF_2 9.00 0.84 735 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63684 BF_2 1.48 0.53 403 646716106 KDR19493.1 157 1.6e-08 Cytochrome c oxidase subunit 7A-related protein, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P13184 128 1.5e-06 Cytochrome c oxidase subunit 7A2, mitochondrial OS=Bos taurus GN=COX7A2 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.63697 BF_2 2.00 0.33 543 441634061 XP_004093242.1 892 1.3e-93 PREDICTED: LOW QUALITY PROTEIN: adenylyl cyclase-associated protein 1 [Nomascus leucogenys] 694885161 XM_009454667.1 543 0 PREDICTED: Pan troglodytes CAP, adenylate cyclase-associated protein 1 (yeast) (CAP1), transcript variant X1, mRNA K17261 CAP1_2, SRV2 adenylyl cyclase-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K17261 Q01518 875 5.0e-93 Adenylyl cyclase-associated protein 1 OS=Homo sapiens GN=CAP1 PE=1 SV=5 PF17082//PF08392//PF01213 Spindle Pole Component 29//FAE1/Type III polyketide synthase-like protein//Adenylate cyclase associated (CAP) N terminal GO:0007010//GO:0030474//GO:0006633 cytoskeleton organization//spindle pole body duplication//fatty acid biosynthetic process GO:0016747//GO:0005200//GO:0003779 transferase activity, transferring acyl groups other than amino-acyl groups//structural constituent of cytoskeleton//actin binding GO:0016020//GO:0005823//GO:0005856 membrane//central plaque of spindle pole body//cytoskeleton KOG2675 Adenylate cyclase-associated protein (CAP/Srv2p) Cluster-8309.63717 BF_2 123.41 0.87 6203 642934282 XP_008200924.1 2056 1.6e-227 PREDICTED: uncharacterized protein LOC103315040 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8C3Y4 387 2.2e-35 Kinetochore-associated protein 1 OS=Mus musculus GN=Kntc1 PE=1 SV=2 PF01125 G10 protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.6373 BF_2 28.16 0.51 2592 270002254 EEZ98701.1 2172 2.3e-241 hypothetical protein TcasGA2_TC001240 [Tribolium castaneum] -- -- -- -- -- K10638 UHRF1, NP95 E3 ubiquitin-protein ligase UHRF1 http://www.genome.jp/dbget-bin/www_bget?ko:K10638 E7EZF3 1915 6.1e-213 E3 ubiquitin-protein ligase UHRF1 OS=Danio rerio GN=uhrf1 PE=1 SV=1 PF02182//PF00628//PF14634//PF00097//PF00240 SAD/SRA domain//PHD-finger//zinc-RING finger domain//Zinc finger, C3HC4 type (RING finger)//Ubiquitin family -- -- GO:0046872//GO:0005515//GO:0008270//GO:0042393 metal ion binding//protein binding//zinc ion binding//histone binding -- -- -- -- Cluster-8309.63739 BF_2 3.00 0.45 568 221118209 XP_002156201.1 179 6.5e-11 PREDICTED: deoxyuridine 5'-triphosphate nucleotidohydrolase-like [Hydra vulgaris] -- -- -- -- -- -- -- -- -- P32542 159 5.5e-10 Pol polyprotein OS=Equine infectious anemia virus (isolate CL22) GN=pol PE=1 SV=1 PF00692 dUTPase GO:0046080 dUTP metabolic process GO:0016787 hydrolase activity -- -- KOG3370 dUTPase Cluster-8309.63741 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63744 BF_2 76.91 2.94 1381 478255961 ENN76162.1 1586 1.1e-173 hypothetical protein YQE_07333, partial [Dendroctonus ponderosae] -- -- -- -- -- K13865 SLC7A3, ATRC3 solute carrier family 7 (cationic amino acid transporter), member 3 http://www.genome.jp/dbget-bin/www_bget?ko:K13865 O08812 1018 3.3e-109 Cationic amino acid transporter 3 OS=Rattus norvegicus GN=Slc7a3 PE=2 SV=1 PF00324//PF13520 Amino acid permease//Amino acid permease GO:0006810//GO:0055085//GO:0003333//GO:0006865 transport//transmembrane transport//amino acid transmembrane transport//amino acid transport GO:0015171 amino acid transmembrane transporter activity GO:0016020 membrane KOG1286 Amino acid transporters Cluster-8309.63757 BF_2 2.62 0.42 547 642935473 XP_008198024.1 194 1.1e-12 PREDICTED: histone H2A deubiquitinase MYSM1 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63773 BF_2 1.00 3.74 262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63775 BF_2 9.00 0.33 1430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63782 BF_2 1.03 1.12 314 270009350 EFA05798.1 394 4.2e-36 hypothetical protein TcasGA2_TC030598 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q810B6 274 1.4e-23 Rabankyrin-5 OS=Mus musculus GN=Ankfy1 PE=2 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63794 BF_2 21.34 0.50 2060 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6381 BF_2 6.00 0.57 725 478252941 ENN73325.1 556 1.6e-54 hypothetical protein YQE_10087, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.63846 BF_2 2.00 0.37 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63865 BF_2 24.36 0.50 2306 328699348 XP_003240910.1 342 3.3e-29 PREDICTED: uncharacterized protein LOC100571439 [Acyrthosiphon pisum] -- -- -- -- -- K09542 CRYAB crystallin, alpha B http://www.genome.jp/dbget-bin/www_bget?ko:K09542 P02518 224 6.5e-17 Heat shock protein 27 OS=Drosophila melanogaster GN=Hsp27 PE=1 SV=2 PF05485//PF03896 THAP domain//Translocon-associated protein (TRAP), alpha subunit -- -- GO:0003676 nucleic acid binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-8309.6387 BF_2 321.10 4.29 3415 91093417 XP_967777.1 670 4.5e-67 PREDICTED: RNA-binding protein 8A [Tribolium castaneum]>gi|270015421|gb|EFA11869.1| tsunagi [Tribolium castaneum] -- -- -- -- -- K12876 RBM8A, Y14 RNA-binding protein 8A http://www.genome.jp/dbget-bin/www_bget?ko:K12876 Q5D018 455 1.6e-43 RNA-binding protein 8A OS=Danio rerio GN=rbm8a PE=2 SV=1 PF00076//PF00478 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//IMP dehydrogenase / GMP reductase domain GO:0006396//GO:0055114 RNA processing//oxidation-reduction process GO:0003676//GO:0000166//GO:0003723//GO:0003824 nucleic acid binding//nucleotide binding//RNA binding//catalytic activity GO:0005737//GO:0005634 cytoplasm//nucleus KOG0130 RNA-binding protein RBM8/Tsunagi (RRM superfamily) Cluster-8309.63873 BF_2 5.00 0.47 736 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63876 BF_2 11.38 0.43 1395 328699094 XP_003240827.1 890 5.7e-93 PREDICTED: uncharacterized protein LOC100571979 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225 DDE superfamily endonuclease//helix-turn-helix, Psq domain -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.63881 BF_2 30.17 0.33 4119 91093699 XP_966579.1 1001 2.3e-105 PREDICTED: probable G-protein coupled receptor Mth-like 1 [Tribolium castaneum]>gi|270014224|gb|EFA10672.1| hypothetical protein TcasGA2_TC010654, partial [Tribolium castaneum] -- -- -- -- -- K04599 MTH G protein-coupled receptor Mth (Methuselah protein) http://www.genome.jp/dbget-bin/www_bget?ko:K04599 Q9VXD9 679 2.0e-69 Probable G-protein coupled receptor Mth-like 1 OS=Drosophila melanogaster GN=mthl1 PE=2 SV=1 PF00503//PF00002 G-protein alpha subunit//7 transmembrane receptor (Secretin family) GO:0007165//GO:0007186 signal transduction//G-protein coupled receptor signaling pathway GO:0031683//GO:0004930//GO:0003924//GO:0019001//GO:0004871 G-protein beta/gamma-subunit complex binding//G-protein coupled receptor activity//GTPase activity//guanyl nucleotide binding//signal transducer activity GO:0016021 integral component of membrane -- -- Cluster-8309.63899 BF_2 3.00 0.70 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63900 BF_2 48.00 0.47 4533 158296890 XP_555219.3 277 2.2e-21 AGAP008244-PA [Anopheles gambiae str. PEST]>gi|157014929|gb|EAL39610.3| AGAP008244-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63902 BF_2 10.34 0.40 1358 607357734 EZA52175.1 161 1.9e-08 hypothetical protein X777_08688, partial [Cerapachys biroi] 462331162 APGK01039783.1 105 2.59175e-45 Dendroctonus ponderosae Seq01039793, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63904 BF_2 56.06 1.87 1543 91085613 XP_969487.1 818 1.4e-84 PREDICTED: uncharacterized protein C2orf47 homolog, mitochondrial [Tribolium castaneum]>gi|270010037|gb|EFA06485.1| hypothetical protein TcasGA2_TC009382 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6AY04 189 5.0e-13 Uncharacterized protein C2orf47 homolog, mitochondrial OS=Rattus norvegicus PE=2 SV=1 PF07961 MBA1-like protein GO:0032979 protein insertion into mitochondrial membrane from inner side -- -- GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.63912 BF_2 53.72 1.34 1962 642933218 XP_008197312.1 1446 2.7e-157 PREDICTED: putative inorganic phosphate cotransporter [Tribolium castaneum]>gi|270011415|gb|EFA07863.1| hypothetical protein TcasGA2_TC005437 [Tribolium castaneum] -- -- -- -- -- K12301 SLC17A5 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12301 Q9V7S5 856 2.9e-90 Putative inorganic phosphate cotransporter OS=Drosophila melanogaster GN=Picot PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.6393 BF_2 10.12 1.05 690 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63946 BF_2 20.20 0.34 2776 478263132 ENN81525.1 709 1.1e-71 hypothetical protein YQE_02054, partial [Dendroctonus ponderosae]>gi|546681765|gb|ERL91791.1| hypothetical protein D910_09116, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q32PN7 182 5.8e-12 Zinc finger protein DZIP1L OS=Danio rerio GN=dzip1l PE=2 SV=1 PF13912//PF06689//PF00096//PF13465 C2H2-type zinc finger//ClpX C4-type zinc finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046983//GO:0046872//GO:0008270 protein dimerization activity//metal ion binding//zinc ion binding -- -- -- -- Cluster-8309.63950 BF_2 20.11 0.54 1855 642928186 XP_008195482.1 1137 1.7e-121 PREDICTED: retinol dehydrogenase 12-like [Tribolium castaneum] -- -- -- -- -- K11153 RDH12 retinol dehydrogenase 12 http://www.genome.jp/dbget-bin/www_bget?ko:K11153 Q8NBN7 713 1.0e-73 Retinol dehydrogenase 13 OS=Homo sapiens GN=RDH13 PE=1 SV=2 PF00106//PF01370 short chain dehydrogenase//NAD dependent epimerase/dehydratase family GO:0008152 metabolic process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- -- -- Cluster-8309.63952 BF_2 5.00 0.66 603 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63963 BF_2 2.00 0.78 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.63967 BF_2 17.00 0.45 1860 478256721 ENN76902.1 1106 6.8e-118 hypothetical protein YQE_06550, partial [Dendroctonus ponderosae]>gi|546681295|gb|ERL91409.1| hypothetical protein D910_08741 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03206 Nitrogen fixation protein NifW GO:0009399 nitrogen fixation -- -- -- -- -- -- Cluster-8309.63968 BF_2 9.00 0.43 1162 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64007 BF_2 6.00 5.12 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64011 BF_2 1.68 0.42 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04272 Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0005246//GO:0042030 calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.64014 BF_2 3.00 0.40 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64017 BF_2 1.00 3.86 261 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64018 BF_2 18.67 0.59 1608 642919863 XP_008192100.1 1054 6.3e-112 PREDICTED: mitochondrial ribonuclease P protein 3 [Tribolium castaneum] -- -- -- -- -- K17655 MRPP3 mitochondrial ribonuclease P protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17655 O15091 476 2.7e-46 Mitochondrial ribonuclease P protein 3 OS=Homo sapiens GN=KIAA0391 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64019 BF_2 29.98 0.80 1858 270005388 EFA01836.1 732 1.6e-74 hypothetical protein TcasGA2_TC007438 [Tribolium castaneum] -- -- -- -- -- K17655 MRPP3 mitochondrial ribonuclease P protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K17655 O15091 411 1.1e-38 Mitochondrial ribonuclease P protein 3 OS=Homo sapiens GN=KIAA0391 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64028 BF_2 1.00 0.57 356 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64033 BF_2 157.18 4.09 1896 557757543 XP_005178504.1 2179 2.6e-242 PREDICTED: putative adenosylhomocysteinase 2 [Musca domestica]>gi|755860451|ref|XP_011290496.1| PREDICTED: putative adenosylhomocysteinase 2 [Musca domestica] 821118450 XM_004463226.2 207 7.24922e-102 PREDICTED: Dasypus novemcinctus adenosylhomocysteinase-like 2 (AHCYL2), transcript variant X6, mRNA K01251 E3.3.1.1, ahcY adenosylhomocysteinase http://www.genome.jp/dbget-bin/www_bget?ko:K01251 Q96HN2 1977 2.9e-220 Adenosylhomocysteinase 3 OS=Homo sapiens GN=AHCYL2 PE=1 SV=1 PF07851//PF07992//PF05221//PF13241//PF02254//PF02882//PF02826 TMPIT-like protein//Pyridine nucleotide-disulphide oxidoreductase//S-adenosyl-L-homocysteine hydrolase//Putative NAD(P)-binding//TrkA-N domain//Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain//D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GO:0055114//GO:0006555//GO:0006779//GO:0006730//GO:0006813//GO:0046487//GO:0009396//GO:0019354 oxidation-reduction process//methionine metabolic process//porphyrin-containing compound biosynthetic process//one-carbon metabolic process//potassium ion transport//glyoxylate metabolic process//folic acid-containing compound biosynthetic process//siroheme biosynthetic process GO:0051287//GO:0004013//GO:0004488//GO:0016491//GO:0003824//GO:0043115 NAD binding//adenosylhomocysteinase activity//methylenetetrahydrofolate dehydrogenase (NADP+) activity//oxidoreductase activity//catalytic activity//precorrin-2 dehydrogenase activity GO:0016021 integral component of membrane KOG1370 S-adenosylhomocysteine hydrolase Cluster-8309.64035 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64041 BF_2 1.00 0.33 415 242002920 XP_002436103.1 169 6.8e-10 scapularisin preproprotein, putative [Ixodes scapularis]>gi|215499439|gb|EEC08933.1| scapularisin preproprotein, putative [Ixodes scapularis] -- -- -- -- -- -- -- -- -- Q86LE4 152 2.6e-09 Defensin OS=Rhipicephalus microplus PE=1 SV=2 PF01097//PF00537//PF12300 Arthropod defensin//Scorpion toxin-like domain//Protein of unknown function (DUF3628) GO:0006810//GO:0006952 transport//defense response GO:0016817//GO:0008200 hydrolase activity, acting on acid anhydrides//ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.64044 BF_2 4.00 0.95 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64048 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64053 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64057 BF_2 26.89 0.41 3035 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03293 Poxvirus DNA-directed RNA polymerase, 18 kD subunit GO:0006144//GO:0006351//GO:0006206//GO:0019083 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process//viral transcription GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.64059 BF_2 3.00 0.42 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64068 BF_2 5.00 0.44 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64071 BF_2 38.00 0.79 2290 546673668 ERL85232.1 1445 4.1e-157 hypothetical protein D910_02653 [Dendroctonus ponderosae] -- -- -- -- -- K10746 EXO1 exonuclease 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10746 Q24558 1088 4.2e-117 Exonuclease 1 OS=Drosophila melanogaster GN=tos PE=1 SV=1 PF13181//PF00867//PF00752//PF13414 Tetratricopeptide repeat//XPG I-region//XPG N-terminal domain//TPR repeat GO:0006281 DNA repair GO:0004518//GO:0005515 nuclease activity//protein binding -- -- KOG2518 5'-3' exonuclease Cluster-8309.64078 BF_2 21.00 0.50 2051 641672114 XP_008185824.1 589 6.7e-58 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02944//PF04827 BESS motif//Plant transposon protein -- -- GO:0016788//GO:0003677 hydrolase activity, acting on ester bonds//DNA binding -- -- -- -- Cluster-8309.64080 BF_2 2.00 0.42 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64101 BF_2 31.47 1.11 1470 91085987 XP_972131.1 1349 3.6e-146 PREDICTED: mitochondrial tRNA-specific 2-thiouridylase 1 isoform X1 [Tribolium castaneum] -- -- -- -- -- K00566 mnmA, trmU, TRMU tRNA-specific 2-thiouridylase http://www.genome.jp/dbget-bin/www_bget?ko:K00566 Q9W5B6 960 1.9e-102 Mitochondrial tRNA-specific 2-thiouridylase 1 OS=Drosophila melanogaster GN=CG3021 PE=2 SV=3 PF02568//PF00733 Thiamine biosynthesis protein (ThiI)//Asparagine synthase GO:0006522//GO:0006529//GO:0006531//GO:0008033 alanine metabolic process//asparagine biosynthetic process//aspartate metabolic process//tRNA processing GO:0004810//GO:0004066 tRNA adenylyltransferase activity//asparagine synthase (glutamine-hydrolyzing) activity -- -- KOG2805 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase Cluster-8309.6412 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64123 BF_2 14.58 0.33 2152 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64153 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64158 BF_2 7.00 0.42 985 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64161 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64163 BF_2 2.00 1.55 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64165 BF_2 9.00 0.86 725 642938169 XP_008190998.1 254 1.7e-19 PREDICTED: G-protein coupled receptor Mth2-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00002//PF05875 7 transmembrane receptor (Secretin family)//Ceramidase GO:0007186//GO:0006672//GO:0006807 G-protein coupled receptor signaling pathway//ceramide metabolic process//nitrogen compound metabolic process GO:0004930//GO:0016811 G-protein coupled receptor activity//hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides GO:0016021 integral component of membrane -- -- Cluster-8309.64166 BF_2 30.24 1.03 1513 642938167 XP_008190994.1 552 9.6e-54 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 279 1.8e-23 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002//PF00001//PF02101 7 transmembrane receptor (Secretin family)//7 transmembrane receptor (rhodopsin family)//Ocular albinism type 1 protein GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.64167 BF_2 18.19 0.43 2063 642938167 XP_008190994.1 546 6.5e-53 PREDICTED: G-protein coupled receptor Mth2-like isoform X2 [Tribolium castaneum]>gi|270016595|gb|EFA13041.1| hypothetical protein TcasGA2_TC010567 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 270 2.7e-22 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF02101//PF00002 Ocular albinism type 1 protein//7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.64168 BF_2 14.57 0.49 1540 642938165 XP_008190990.1 440 9.5e-41 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 221 9.7e-17 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.64177 BF_2 25.60 0.87 1518 189234808 XP_001808956.1 1168 3.6e-125 PREDICTED: uncharacterized protein LOC100142496 isoform X1 [Tribolium castaneum]>gi|270002244|gb|EEZ98691.1| hypothetical protein TcasGA2_TC001227 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64204 BF_2 15.68 0.38 2028 270004026 EFA00474.1 380 1.1e-33 hypothetical protein TcasGA2_TC003333 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13129 137 7.1e-07 Luciferin 4-monooxygenase OS=Luciola cruciata PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.64206 BF_2 4.00 0.32 809 642928198 XP_008195486.1 471 1.3e-44 PREDICTED: thyrotropin receptor-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13855//PF00560//PF04226 Leucine rich repeat//Leucine Rich Repeat//Transglycosylase associated protein -- -- GO:0005515 protein binding GO:0016021 integral component of membrane -- -- Cluster-8309.64234 BF_2 6.95 0.36 1099 642914128 XP_008201556.1 583 1.8e-57 PREDICTED: colorectal mutant cancer protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P23508 182 2.3e-12 Colorectal mutant cancer protein OS=Homo sapiens GN=MCC PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6430 BF_2 36.84 0.60 2846 642911311 XP_008199365.1 852 3.0e-88 PREDICTED: apolipoprotein D-like [Tribolium castaneum]>gi|270014830|gb|EFA11278.1| hypothetical protein TcasGA2_TC010813 [Tribolium castaneum] -- -- -- -- -- K03098 APOD apolipoprotein D and lipocalin family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03098 P05090 305 3.3e-26 Apolipoprotein D OS=Homo sapiens GN=APOD PE=1 SV=1 PF03973//PF13417 Triabin//Glutathione S-transferase, N-terminal domain GO:0030682 evasion or tolerance of host defense response GO:0005515//GO:0031409 protein binding//pigment binding GO:0005576 extracellular region KOG4824 Apolipoprotein D/Lipocalin Cluster-8309.64320 BF_2 49.25 2.20 1225 642914592 XP_972516.3 489 1.6e-46 PREDICTED: putative peptidyl-tRNA hydrolase PTRHD1 [Tribolium castaneum]>gi|270002266|gb|EEZ98713.1| hypothetical protein TcasGA2_TC001254 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZ85 330 1.8e-29 Putative peptidyl-tRNA hydrolase PTRHD1 OS=Bos taurus GN=PTRHD1 PE=2 SV=2 PF07690//PF01981 Major Facilitator Superfamily//Peptidyl-tRNA hydrolase PTH2 GO:0055085//GO:0006470//GO:0006570//GO:0035335 transmembrane transport//protein dephosphorylation//tyrosine metabolic process//peptidyl-tyrosine dephosphorylation GO:0004045//GO:0004725 aminoacyl-tRNA hydrolase activity//protein tyrosine phosphatase activity GO:0016021 integral component of membrane KOG3305 Uncharacterized conserved protein Cluster-8309.64325 BF_2 2.00 0.36 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64334 BF_2 3.00 0.39 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64337 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64341 BF_2 58.24 0.72 3679 642929042 XP_973795.3 1220 8.2e-131 PREDICTED: homeobox protein Nkx-2.1-like [Tribolium castaneum] 736214483 XM_010779878.1 99 1.54432e-41 PREDICTED: Notothenia coriiceps NK2 homeobox 4 (nkx2-4), transcript variant X2, mRNA K09342 NKX2-1, TITF1 homeobox protein Nkx-2.1 http://www.genome.jp/dbget-bin/www_bget?ko:K09342 P23441 388 1.0e-35 Homeobox protein Nkx-2.1 OS=Rattus norvegicus GN=Nkx2-1 PE=1 SV=1 PF13374//PF00046 Tetratricopeptide repeat//Homeobox domain -- -- GO:0003677//GO:0005515 DNA binding//protein binding -- -- KOG0842 Transcription factor tinman/NKX2-3, contains HOX domain Cluster-8309.64358 BF_2 3.00 1.09 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64361 BF_2 9.28 2.16 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6437 BF_2 7.00 0.67 721 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64376 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64377 BF_2 2.00 0.82 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64383 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64397 BF_2 39.00 0.56 3225 642925381 XP_008194525.1 818 2.9e-84 PREDICTED: putative sodium-coupled neutral amino acid transporter 11 [Tribolium castaneum] -- -- -- -- -- K14997 SLC38A11 solute carrier family 38 (sodium-coupled neutral amino acid transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14997 Q5EA97 443 3.7e-42 Putative sodium-coupled neutral amino acid transporter 11 OS=Bos taurus GN=SLC38A11 PE=2 SV=1 PF00025 ADP-ribosylation factor family -- -- GO:0005525 GTP binding -- -- KOG1305 Amino acid transporter protein Cluster-8309.64398 BF_2 2.00 0.55 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64399 BF_2 54.55 1.98 1440 91077544 XP_971725.1 1412 1.7e-153 PREDICTED: tyrosine-protein phosphatase non-receptor type 13-like isoform X1 [Tribolium castaneum] 642914119 XM_008203330.1 396 0 PREDICTED: Tribolium castaneum tyrosine-protein phosphatase non-receptor type 13-like (LOC660401), transcript variant X5, mRNA K02374 PTPN13, FAP-1 tyrosine-protein phosphatase non-receptor type 13 http://www.genome.jp/dbget-bin/www_bget?ko:K02374 Q12923 206 5.0e-15 Tyrosine-protein phosphatase non-receptor type 13 OS=Homo sapiens GN=PTPN13 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6440 BF_2 1.00 0.49 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64403 BF_2 1.00 1.11 313 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64416 BF_2 9.37 0.41 1248 646693425 KDR07697.1 319 8.3e-27 Proton-coupled amino acid transporter 4 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64427 BF_2 14.00 0.37 1849 725574505 XP_003930689.2 1976 8.9e-219 PREDICTED: vimentin [Saimiri boliviensis boliviensis] 767960475 XM_011519649.1 1849 0 PREDICTED: Homo sapiens vimentin (VIM), transcript variant X2, mRNA K07606 VIM vimentin http://www.genome.jp/dbget-bin/www_bget?ko:K07606 P08670 1949 4.9e-217 Vimentin OS=Homo sapiens GN=VIM PE=1 SV=4 PF10620//PF10473//PF07926//PF00038//PF02183//PF04513//PF08702//PF00111//PF06009//PF16331//PF00170//PF04732//PF13851//PF10186 Phosphoribosyl-dephospho-CoA transferase MdcG//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//TPR/MLP1/MLP2-like protein//Intermediate filament protein//Homeobox associated leucine zipper//Baculovirus polyhedron envelope protein, PEP, C terminus//Fibrinogen alpha/beta chain family//2Fe-2S iron-sulfur cluster binding domain//Laminin Domain II//TolA binding protein trimerisation//bZIP transcription factor//Intermediate filament head (DNA binding) region//Growth-arrest specific micro-tubule binding//Vacuolar sorting 38 and autophagy-related subunit 14 GO:0006606//GO:0006355//GO:0006118//GO:0010508//GO:0007165//GO:0070206//GO:0051258//GO:0030168//GO:0007155//GO:0048870 protein import into nucleus//regulation of transcription, DNA-templated//obsolete electron transport//positive regulation of autophagy//signal transduction//protein trimerization//protein polymerization//platelet activation//cell adhesion//cell motility GO:0005102//GO:0043565//GO:0051536//GO:0016779//GO:0003700//GO:0008134//GO:0045502//GO:0005198//GO:0042803//GO:0009055//GO:0030674 receptor binding//sequence-specific DNA binding//iron-sulfur cluster binding//nucleotidyltransferase activity//transcription factor activity, sequence-specific DNA binding//transcription factor binding//dynein binding//structural molecule activity//protein homodimerization activity//electron carrier activity//protein binding, bridging GO:0005577//GO:0031514//GO:0019028//GO:0005882//GO:0030286//GO:0019031//GO:0005667 fibrinogen complex//motile cilium//viral capsid//intermediate filament//dynein complex//viral envelope//transcription factor complex -- -- Cluster-8309.64428 BF_2 6.00 0.53 761 91094063 XP_969813.1 451 2.5e-42 PREDICTED: cytochrome P450 6a2 [Tribolium castaneum]>gi|270016180|gb|EFA12628.1| cytochrome P450 6BR2 [Tribolium castaneum] -- -- -- -- -- K07424 CYP3A cytochrome P450, family 3, subfamily A http://www.genome.jp/dbget-bin/www_bget?ko:K07424 Q964T2 381 1.3e-35 Cytochrome P450 9e2 OS=Blattella germanica GN=CYP9E2 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0046872//GO:0005506//GO:0016491//GO:0020037//GO:0016705 metal ion binding//iron ion binding//oxidoreductase activity//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.6443 BF_2 69.72 2.16 1636 478252123 ENN72554.1 1227 5.6e-132 hypothetical protein YQE_10894, partial [Dendroctonus ponderosae] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51523 447 6.4e-43 Zinc finger protein 84 OS=Homo sapiens GN=ZNF84 PE=1 SV=2 PF00096//PF13465//PF02724//PF07776//PF02535 Zinc finger, C2H2 type//Zinc-finger double domain//CDC45-like protein//Zinc-finger associated domain (zf-AD)//ZIP Zinc transporter GO:0055085//GO:0030001//GO:0006270 transmembrane transport//metal ion transport//DNA replication initiation GO:0046873//GO:0008270//GO:0046872 metal ion transmembrane transporter activity//zinc ion binding//metal ion binding GO:0016020//GO:0005634 membrane//nucleus -- -- Cluster-8309.64434 BF_2 255.00 5.39 2267 158286343 XP_001688060.1 396 1.8e-35 AGAP007070-PA [Anopheles gambiae str. PEST]>gi|157020423|gb|EDO64709.1| AGAP007070-PA [Anopheles gambiae str. PEST] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.64449 BF_2 5.00 0.35 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64451 BF_2 4.00 0.60 567 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64461 BF_2 80.62 3.75 1187 642924692 XP_008194400.1 168 2.5e-09 PREDICTED: G-protein coupled receptor Mth2-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64467 BF_2 1.00 1.19 309 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64498 BF_2 15.97 0.88 1045 478251660 ENN72114.1 586 7.6e-58 hypothetical protein YQE_11173, partial [Dendroctonus ponderosae]>gi|478262747|gb|ENN81278.1| hypothetical protein YQE_02314, partial [Dendroctonus ponderosae]>gi|546680914|gb|ERL91088.1| hypothetical protein D910_08430 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VMA0 246 8.3e-20 Non-structural maintenance of chromosomes element 1 homolog OS=Drosophila melanogaster GN=CG11329 PE=1 SV=1 PF09494//PF13639//PF00130//PF12861//PF12678//PF07574 Slx4 endonuclease//Ring finger domain//Phorbol esters/diacylglycerol binding domain (C1 domain)//Anaphase-promoting complex subunit 11 RING-H2 finger//RING-H2 zinc finger//Nse1 non-SMC component of SMC5-6 complex GO:0006260//GO:0035556//GO:0006308//GO:0006281//GO:0016567 DNA replication//intracellular signal transduction//DNA catabolic process//DNA repair//protein ubiquitination GO:0008270//GO:0017108//GO:0004842//GO:0005515 zinc ion binding//5'-flap endonuclease activity//ubiquitin-protein transferase activity//protein binding GO:0033557//GO:0005634//GO:0030915//GO:0005680 Slx1-Slx4 complex//nucleus//Smc5-Smc6 complex//anaphase-promoting complex -- -- Cluster-8309.6451 BF_2 15.94 0.78 1147 765147862 XP_011484596.1 475 6.2e-45 PREDICTED: zinc finger protein 883-like [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q6P2D0 421 4.7e-40 Zinc finger protein 1 homolog OS=Homo sapiens GN=ZFP1 PE=2 SV=2 PF05495//PF00096//PF07776//PF13465//PF16622//PF01844//PF13912//PF00412 CHY zinc finger//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//Zinc-finger double domain//zinc-finger C2H2-type//HNH endonuclease//C2H2-type zinc finger//LIM domain -- -- GO:0008270//GO:0004519//GO:0003676//GO:0046872 zinc ion binding//endonuclease activity//nucleic acid binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.64511 BF_2 39.00 0.74 2481 270002758 EEZ99205.1 813 8.6e-84 serine protease P10 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 487 2.2e-47 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089//PF05109 Trypsin//Herpes virus major outer envelope glycoprotein (BLLF1) GO:0019058//GO:0006508 viral life cycle//proteolysis GO:0004252 serine-type endopeptidase activity GO:0019031 viral envelope -- -- Cluster-8309.64512 BF_2 170.00 9.06 1072 91079418 XP_967497.1 1072 3.4e-114 PREDICTED: exosome complex component RRP42 [Tribolium castaneum]>gi|642917207|ref|XP_008191163.1| PREDICTED: exosome complex component RRP42 [Tribolium castaneum]>gi|270003471|gb|EEZ99918.1| hypothetical protein TcasGA2_TC002710 [Tribolium castaneum] -- -- -- -- -- K12589 RRP42, EXOSC7 exosome complex component RRP42 http://www.genome.jp/dbget-bin/www_bget?ko:K12589 Q9D0M0 636 5.1e-65 Exosome complex exonuclease RRP42 OS=Mus musculus GN=Exosc7 PE=2 SV=2 PF00501//PF06338 AMP-binding enzyme//ComK protein GO:0008152//GO:0030420 metabolic process//establishment of competence for transformation GO:0003824 catalytic activity -- -- KOG1612 Exosomal 3'-5' exoribonuclease complex, subunit Rrp42 Cluster-8309.64515 BF_2 5.00 0.51 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6452 BF_2 9.00 5.89 346 765166492 XP_011492060.1 330 1.2e-28 PREDICTED: zinc finger protein 26-like isoform X1 [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86WZ6 319 9.4e-29 Zinc finger protein 227 OS=Homo sapiens GN=ZNF227 PE=1 SV=1 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.64522 BF_2 2.00 1.40 341 270014080 EFA10528.1 291 4.0e-24 hypothetical protein TcasGA2_TC012780 [Tribolium castaneum] 751206253 XM_011157338.1 52 1.75143e-16 PREDICTED: Solenopsis invicta dedicator of cytokinesis protein 3 (LOC105193020), partial mRNA K05727 DOCK3 dedicator of cytokinesis protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K05727 Q8IZD9 184 4.2e-13 Dedicator of cytokinesis protein 3 OS=Homo sapiens GN=DOCK3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64523 BF_2 1.00 1.24 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64535 BF_2 3.00 0.33 670 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64545 BF_2 2.00 0.48 462 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05739 SNARE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.64554 BF_2 4.00 0.37 743 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6456 BF_2 16.00 0.36 2140 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64567 BF_2 26.93 0.85 1616 861597654 KMQ83382.1 202 4.0e-13 transcription factor adf-1 [Lasius niger] -- -- -- -- -- K09427 ADF1 Adh transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09427 P05552 175 2.2e-11 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64569 BF_2 6.77 0.36 1072 817196071 XP_012273605.1 192 3.8e-12 PREDICTED: uncharacterized protein LOC105696042 isoform X1 [Orussus abietinus] -- -- -- -- -- -- -- -- -- P05552 137 3.7e-07 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF04719 hTAFII28-like protein conserved region GO:0006367 transcription initiation from RNA polymerase II promoter -- -- GO:0005634 nucleus -- -- Cluster-8309.6457 BF_2 12.00 0.45 1391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64571 BF_2 23.66 1.01 1269 861597654 KMQ83382.1 202 3.1e-13 transcription factor adf-1 [Lasius niger] -- -- -- -- -- K09427 ADF1 Adh transcription factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K09427 P05552 175 1.7e-11 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64577 BF_2 2.00 0.58 430 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6460 BF_2 23.00 1.05 1204 752863744 XP_011268239.1 370 9.8e-33 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07267 Nucleopolyhedrovirus capsid protein P87 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.64606 BF_2 38.24 2.31 981 642910346 XP_970887.2 560 7.4e-55 PREDICTED: serine/threonine-protein kinase MAK isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64615 BF_2 8.00 0.67 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04813 Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus GO:0045893 positive regulation of transcription, DNA-templated -- -- GO:0005634 nucleus -- -- Cluster-8309.64616 BF_2 1.00 0.73 338 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64617 BF_2 2.00 0.43 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64621 BF_2 4.00 0.37 740 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64622 BF_2 8.00 0.38 1165 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64626 BF_2 2.00 1.34 344 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64634 BF_2 5.82 0.40 900 478256737 ENN76918.1 293 6.2e-24 hypothetical protein YQE_06565, partial [Dendroctonus ponderosae]>gi|546672595|gb|ERL84396.1| hypothetical protein D910_01829 [Dendroctonus ponderosae] 166208658 EU177511.1 42 1.78317e-10 Pinctada fucata shematrin-1 mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64635 BF_2 51.45 0.63 3703 642928611 XP_008199978.1 1514 6.7e-165 PREDICTED: FERM domain-containing protein 8 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q0IJ35 348 4.4e-31 FERM domain-containing protein 8 OS=Xenopus tropicalis GN=frmd8 PE=2 SV=1 PF01527//PF04218 Transposase//CENP-B N-terminal DNA-binding domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0004803 DNA binding//transposase activity -- -- KOG4335 FERM domain-containing protein KRIT1 Cluster-8309.64659 BF_2 5.16 0.31 975 642934559 XP_008197714.1 865 3.1e-90 PREDICTED: uncharacterized protein LOC658526 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O94889 221 6.1e-17 Kelch-like protein 18 OS=Homo sapiens GN=KLHL18 PE=1 SV=3 PF00651//PF03931//PF02214 BTB/POZ domain//Skp1 family, tetramerisation domain//BTB/POZ domain GO:0051260//GO:0006511 protein homooligomerization//ubiquitin-dependent protein catabolic process GO:0005515 protein binding -- -- KOG4441 Proteins containing BTB/POZ and Kelch domains, involved in regulatory/signal transduction processes Cluster-8309.64670 BF_2 3.00 0.62 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64671 BF_2 36.22 0.52 3191 270007722 EFA04170.1 1680 3.2e-184 hypothetical protein TcasGA2_TC014419 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3TZZ7 875 2.9e-92 Extended synaptotagmin-2 OS=Mus musculus GN=Esyt2 PE=1 SV=1 PF17047//PF00168 Synaptotagmin-like mitochondrial-lipid-binding domain//C2 domain -- -- GO:0008289//GO:0005515 lipid binding//protein binding -- -- KOG1012 Ca2+-dependent lipid-binding protein CLB1/vesicle protein vp115/Granuphilin A, contains C2 domain Cluster-8309.64675 BF_2 47.00 0.92 2422 642937007 XP_008198650.1 1275 2.2e-137 PREDICTED: neuromedin-U receptor 2-like [Tribolium castaneum]>gi|674279351|gb|AIL02854.1| G-protein coupled receptor [Tribolium castaneum]>gi|728893169|gb|AIZ00518.1| pyrokinin 1 receptor A [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q58CW4 502 4.0e-49 Neuromedin-U receptor 2 OS=Bos taurus GN=NMUR2 PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.64685 BF_2 1.00 0.31 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64687 BF_2 6.00 1.05 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64690 BF_2 3.00 0.34 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64707 BF_2 20.94 0.32 3015 642939902 XP_008200259.1 985 1.2e-103 PREDICTED: acidic repeat-containing protein-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96QF7 383 3.1e-35 Acidic repeat-containing protein OS=Homo sapiens GN=ACRC PE=2 SV=1 PF02290 Signal recognition particle 14kD protein GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0030942//GO:0008312 endoplasmic reticulum signal peptide binding//7S RNA binding GO:0005786 signal recognition particle, endoplasmic reticulum targeting KOG3854 SPRT-like metalloprotease Cluster-8309.6471 BF_2 2.00 27.86 225 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64712 BF_2 11.00 0.38 1491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64713 BF_2 17.12 0.56 1556 642914178 XP_008201577.1 300 1.7e-24 PREDICTED: spindle pole body component 110-like [Tribolium castaneum]>gi|270001578|gb|EEZ98025.1| hypothetical protein TcasGA2_TC000425 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03800 Nuf2 family GO:0007067 mitotic nuclear division -- -- GO:0000775 chromosome, centromeric region -- -- Cluster-8309.64714 BF_2 17.72 2.86 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64717 BF_2 4.76 0.96 495 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64718 BF_2 4.00 0.39 720 295981455 CBL87044.1 1218 2.7e-131 MHC class I antigen [Homo sapiens] 33187147 U02935.2 705 0 HSU02935 Homo sapiens HLA-A2 gene, enhancer region and complete cds K06751 MHC1 major histocompatibility complex, class I http://www.genome.jp/dbget-bin/www_bget?ko:K06751 P01892 1220 6.5e-133 HLA class I histocompatibility antigen, A-2 alpha chain OS=Homo sapiens GN=HLA-A PE=1 SV=1 PF00129//PF16497 Class I Histocompatibility antigen, domains alpha 1 and 2//MHC-I family domain GO:0006955 immune response -- -- -- -- -- -- Cluster-8309.6472 BF_2 2.00 0.32 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64722 BF_2 26.04 1.26 1152 91092196 XP_969285.1 582 2.4e-57 PREDICTED: plasminogen receptor (KT) isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9D3P8 266 4.4e-22 Plasminogen receptor (KT) OS=Mus musculus GN=Plgrkt PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6473 BF_2 6.00 0.43 873 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF16178//PF05699 Dimerisation domain of Ca+-activated chloride-channel, anoctamin//hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.64730 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64749 BF_2 8.26 0.43 1092 749784255 XP_011146009.1 568 9.7e-56 PREDICTED: uncharacterized protein LOC105187106, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01498 Transposase GO:0006313//GO:0015074 transposition, DNA-mediated//DNA integration GO:0003677 DNA binding -- -- -- -- Cluster-8309.64750 BF_2 41.41 0.43 4356 642915022 XP_008190487.1 3658 0.0e+00 PREDICTED: cubilin [Tribolium castaneum] 642915021 XM_008192265.1 777 0 PREDICTED: Tribolium castaneum cubilin (LOC662433), mRNA -- -- -- -- Q9JLB4 403 2.2e-37 Cubilin OS=Mus musculus GN=Cubn PE=1 SV=3 PF05393//PF02480//PF00057 Human adenovirus early E3A glycoprotein//Alphaherpesvirus glycoprotein E//Low-density lipoprotein receptor domain class A -- -- GO:0005515 protein binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG4292 Cubilin, multiligand receptor mediating cobalamin absorption Cluster-8309.64754 BF_2 3.00 0.43 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64758 BF_2 9.00 0.39 1262 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64792 BF_2 9.91 0.32 1577 642927980 XP_008195470.1 223 1.4e-15 PREDICTED: uncharacterized protein LOC662711, partial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08685 GON domain -- -- GO:0004222//GO:0008270 metalloendopeptidase activity//zinc ion binding -- -- -- -- Cluster-8309.64793 BF_2 2.00 1.31 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64807 BF_2 2.00 0.34 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6481 BF_2 4.00 0.32 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64810 BF_2 2.00 2.98 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64816 BF_2 4.00 0.34 779 827544931 XP_012545058.1 193 2.1e-12 PREDICTED: uncharacterized protein LOC105841489 [Bombyx mori] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6483 BF_2 2.00 0.70 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64843 BF_2 15.00 0.38 1924 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64851 BF_2 7.00 0.56 807 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64861 BF_2 7.00 0.32 1207 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64873 BF_2 9.00 0.50 1044 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07810 TMC domain -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.64877 BF_2 14.00 5.01 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03688 Nepovirus coat protein, C-terminal domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.64880 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64881 BF_2 21.04 1.11 1078 642926342 XP_008194886.1 1430 1.1e-155 PREDICTED: small G protein signaling modulator 1 isoform X2 [Tribolium castaneum] 462294937 APGK01052928.1 71 1.62692e-26 Dendroctonus ponderosae Seq01052938, whole genome shotgun sequence -- -- -- -- Q2NKQ1 880 2.6e-93 Small G protein signaling modulator 1 OS=Homo sapiens GN=SGSM1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1648 Uncharacterized conserved protein, contains RUN, BRK and TBC domains Cluster-8309.64890 BF_2 9.00 0.35 1350 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64898 BF_2 4.00 0.34 783 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64899 BF_2 5.00 0.73 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64904 BF_2 14.57 1.00 898 728418700 AIY68378.1 423 5.2e-39 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P16854 265 4.5e-22 Esterase B1 OS=Culex pipiens GN=B1 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6491 BF_2 109.42 2.22 2347 546675717 ERL86854.1 271 5.7e-21 hypothetical protein D910_04257 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03845//PF07776 Spore germination protein//Zinc-finger associated domain (zf-AD) GO:0009847 spore germination GO:0008270 zinc ion binding GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.64911 BF_2 2.04 0.42 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64922 BF_2 14.00 0.97 890 642933869 XP_008197546.1 249 7.7e-19 PREDICTED: uncharacterized protein LOC103314166 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64924 BF_2 14.46 0.46 1598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14980 TIP39 peptide GO:0007218 neuropeptide signaling pathway -- -- GO:0005576 extracellular region -- -- Cluster-8309.6493 BF_2 2.00 0.33 539 -- -- -- -- -- 257286307 AC236507.3 131 3.4845e-60 Biomphalaria glabrata BAC clone BG_BBa-11G10 from chromosome unknown, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64934 BF_2 6.00 5.75 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6494 BF_2 2.00 1.68 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64948 BF_2 24.61 1.42 1013 270014663 EFA11111.1 1629 8.4e-179 hypothetical protein TcasGA2_TC004709 [Tribolium castaneum] 642910412 XM_008192502.1 268 4.69625e-136 PREDICTED: Tribolium castaneum agrin-like (LOC100141763), mRNA K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 P31696 531 7.2e-53 Agrin OS=Gallus gallus GN=AGRN PE=1 SV=3 PF07648//PF00050//PF00008 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain//EGF-like domain -- -- GO:0005515 protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.64949 BF_2 31.00 0.94 1666 642910413 XP_008190724.1 1964 2.0e-217 PREDICTED: agrin-like [Tribolium castaneum] -- -- -- -- -- K06254 AGRN agrin http://www.genome.jp/dbget-bin/www_bget?ko:K06254 A2ASQ1 541 8.2e-54 Agrin OS=Mus musculus GN=Agrn PE=1 SV=1 PF03146//PF00050//PF07648 Agrin NtA domain//Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain GO:0007213//GO:0043113 G-protein coupled acetylcholine receptor signaling pathway//receptor clustering GO:0043236//GO:0005515 laminin binding//protein binding -- -- KOG3649 FOG: Kazal-type serine protease inhibitor domain Cluster-8309.6495 BF_2 157.41 7.78 1134 332376071 AEE63176.1 489 1.5e-46 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q60534 227 1.4e-17 Androgen-dependent TFPI-regulating protein OS=Mesocricetus auratus GN=ADTRP PE=2 SV=1 PF04750 FAR-17a/AIG1-like protein -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.64952 BF_2 2.00 0.60 427 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64953 BF_2 11.00 1.50 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64954 BF_2 13.89 2.70 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02203 Tar ligand binding domain homologue GO:0007165//GO:0006935 signal transduction//chemotaxis GO:0004888 transmembrane signaling receptor activity GO:0016020 membrane -- -- Cluster-8309.64956 BF_2 6.00 1.45 460 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64960 BF_2 0.47 0.34 339 820858353 XP_012346204.1 325 4.5e-28 PREDICTED: LOW QUALITY PROTEIN: serine/threonine-protein kinase VRK1-like [Apis florea] 665797669 XM_008548452.1 35 4.90696e-07 PREDICTED: Microplitis demolitor nucleosomal histone kinase 1-like (LOC103570647), mRNA K08816 VRK vaccinia related kinase http://www.genome.jp/dbget-bin/www_bget?ko:K08816 Q7KRY6 255 2.4e-21 Nucleosomal histone kinase 1 OS=Drosophila melanogaster GN=ball PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.64966 BF_2 3.00 0.57 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6497 BF_2 8.40 0.47 1037 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.64978 BF_2 15.41 0.31 2374 642913062 XP_008201373.1 548 4.4e-53 PREDICTED: uncharacterized protein LOC103315170 [Tribolium castaneum]>gi|270001839|gb|EEZ98286.1| hypothetical protein TcasGA2_TC000734 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00243 Nerve growth factor family GO:0007165 signal transduction GO:0005102 receptor binding -- -- -- -- Cluster-8309.64984 BF_2 8.83 0.37 1278 649572295 NP_001280525.1 287 4.4e-23 cuticle protein precursor [Tribolium castaneum]>gi|270003230|gb|EEZ99677.1| hypothetical protein TcasGA2_TC002434 [Tribolium castaneum]>gi|334261603|gb|AEG74042.1| cuticle protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P26968 161 7.3e-10 Adult-specific cuticular protein ACP-22 OS=Tenebrio molitor GN=ACP22 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65001 BF_2 2.00 0.70 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65024 BF_2 10.00 0.82 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65025 BF_2 20.73 0.81 1359 642934936 XP_008195867.1 170 1.7e-09 PREDICTED: mushroom body large-type Kenyon cell-specific protein 1 isoform X1 [Tribolium castaneum] 642934935 XM_008197645.1 130 3.28471e-59 PREDICTED: Tribolium castaneum mushroom body large-type Kenyon cell-specific protein 1 (LOC655012), transcript variant X1, mRNA -- -- -- -- Q95YM8 139 2.8e-07 Mushroom body large-type Kenyon cell-specific protein 1 OS=Apis mellifera GN=Mblk-1 PE=1 SV=1 PF01749 Importin beta binding domain GO:0006606//GO:0015031 protein import into nucleus//protein transport GO:0008565 protein transporter activity GO:0005634//GO:0005737 nucleus//cytoplasm -- -- Cluster-8309.65028 BF_2 30.00 0.73 2009 270015871 EFA12319.1 1455 2.5e-158 hypothetical protein TcasGA2_TC004220 [Tribolium castaneum] -- -- -- -- -- K01116 PLCG1 phosphatidylinositol phospholipase C, gamma-1 http://www.genome.jp/dbget-bin/www_bget?ko:K01116 Q62077 1087 4.8e-117 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 OS=Mus musculus GN=Plcg1 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1264 Phospholipase C Cluster-8309.6503 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65051 BF_2 34.00 0.58 2720 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65058 BF_2 5.00 0.77 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65061 BF_2 4.00 0.96 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65067 BF_2 3.00 5.60 288 642926348 XP_008194888.1 329 1.3e-28 PREDICTED: fructose-bisphosphate aldolase isoform X1 [Tribolium castaneum] 221048060 FJ438514.1 60 5.17854e-21 Epinephelus coioides fructose-bisphosphate aldolase mRNA, partial cds K01623 ALDO fructose-bisphosphate aldolase, class I http://www.genome.jp/dbget-bin/www_bget?ko:K01623 P07764 277 5.8e-24 Fructose-bisphosphate aldolase OS=Drosophila melanogaster GN=Ald PE=1 SV=5 PF00274 Fructose-bisphosphate aldolase class-I GO:0006096//GO:0006098//GO:0006020//GO:0006094//GO:0015976//GO:0006013//GO:0006000 glycolytic process//pentose-phosphate shunt//inositol metabolic process//gluconeogenesis//carbon utilization//mannose metabolic process//fructose metabolic process GO:0004332 fructose-bisphosphate aldolase activity -- -- KOG1557 Fructose-biphosphate aldolase Cluster-8309.65071 BF_2 16.00 0.34 2251 189235901 XP_001808773.1 661 3.3e-66 PREDICTED: uncharacterized protein LOC100142021 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65077 BF_2 1.00 1.26 306 14010625 AAK52058.1 240 2.9e-18 RNA-directed DNA polymerase [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- P04323 231 1.3e-18 Retrovirus-related Pol polyprotein from transposon 17.6 OS=Drosophila melanogaster GN=pol PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65097 BF_2 58.62 3.42 1005 546681140 ERL91290.1 1012 2.9e-107 hypothetical protein D910_08623 [Dendroctonus ponderosae] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 564 1.1e-56 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF00916 Sulfate permease family GO:0008272 sulfate transport GO:0015116 sulfate transmembrane transporter activity GO:0016021 integral component of membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8309.651 BF_2 2.30 0.90 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6510 BF_2 9.00 1.03 653 397516651 XP_003828537.1 1149 2.5e-123 PREDICTED: elongation factor 1-gamma [Pan paniscus] 649152470 KJ905736.1 653 0 Synthetic construct Homo sapiens clone ccsbBroadEn_15406 EEF1G gene, encodes complete protein K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 P26641 1149 1.0e-124 Elongation factor 1-gamma OS=Homo sapiens GN=EEF1G PE=1 SV=3 PF13417//PF02798//PF13409 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- KOG0867 Glutathione S-transferase Cluster-8309.65108 BF_2 6.00 0.45 841 333441020 AEF32709.1 550 9.1e-54 prostaglandin D synthase [Eriocheir sinensis] 333103083 JF715388.1 164 2.51839e-78 Scylla paramamosain clone SP04 microsatellite sequence -- -- -- -- O60760 320 1.8e-28 Hematopoietic prostaglandin D synthase OS=Homo sapiens GN=HPGDS PE=1 SV=3 PF13409//PF02798//PF15761//PF13417 Glutathione S-transferase, N-terminal domain//Glutathione S-transferase, N-terminal domain//Immortalisation up-regulated protein//Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding GO:0005634 nucleus -- -- Cluster-8309.6511 BF_2 4.00 0.38 728 55977740 Q29387.2 1007 8.0e-107 RecName: Full=Elongation factor 1-gamma; Short=EF-1-gamma; AltName: Full=eEF-1B gamma, partial [Sus scrofa]>gi|19111049|gb|AAL85414.1|AF480162_1 eukaryotic elongation factor 1 gamma-like protein [Sus scrofa] 194390423 AK300203.1 728 0 Homo sapiens cDNA FLJ56389 complete cds, highly similar to Elongation factor 1-gamma K03233 EEF1G elongation factor 1-gamma http://www.genome.jp/dbget-bin/www_bget?ko:K03233 Q4R7H5 1017 2.3e-109 Elongation factor 1-gamma OS=Macaca fascicularis GN=EEF1G PE=2 SV=1 PF00647 Elongation factor 1 gamma, conserved domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1627 Translation elongation factor EF-1 gamma Cluster-8309.65145 BF_2 4.00 0.36 752 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65148 BF_2 31.00 0.52 2801 310743896 BAJ23879.1 3995 0.0e+00 glycogen phosphorylase [Marsupenaeus japonicus] 310743895 AB596876.1 950 0 Marsupenaeus japonicus MjGP mRNA for glycogen phosphorylase, complete cds K00688 E2.4.1.1, glgP, PYG starch phosphorylase http://www.genome.jp/dbget-bin/www_bget?ko:K00688 Q9XTL9 3424 0.0e+00 Glycogen phosphorylase OS=Drosophila melanogaster GN=GlyP PE=2 SV=2 PF00276//PF00343 Ribosomal protein L23//Carbohydrate phosphorylase GO:0006412//GO:0005975//GO:0042254 translation//carbohydrate metabolic process//ribosome biogenesis GO:0008184//GO:0003735 glycogen phosphorylase activity//structural constituent of ribosome GO:0005840 ribosome KOG2099 Glycogen phosphorylase Cluster-8309.65157 BF_2 20.00 0.71 1464 657189747 AID47196.1 1318 1.4e-142 trypsin [Macrophthalmus japonicus] -- -- -- -- -- -- -- -- -- P83748 356 2.1e-32 Serine protease 30 OS=Rattus norvegicus GN=Prss30 PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.65176 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65183 BF_2 6.00 0.57 731 82795517 ABB91672.1 328 4.4e-28 arthrodial cuticle protein AMP13.4 [Callinectes sapidus] 82795516 DQ288147.1 511 0 Callinectes sapidus arthrodial cuticle protein AMP13.4 mRNA, complete cds -- -- -- -- P81579 303 1.4e-26 Cuticle protein AM1274 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.65195 BF_2 10.66 0.72 907 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65211 BF_2 57.00 4.78 786 328899797 AEB54649.1 953 1.6e-100 ribosomal protein S6 [Procambarus clarkii] 194763267 XM_001963719.1 210 6.29808e-104 Drosophila ananassae GF21093 (Dana\GF21093), mRNA K02991 RP-S6e, RPS6 small subunit ribosomal protein S6e http://www.genome.jp/dbget-bin/www_bget?ko:K02991 Q2PQM1 847 1.3e-89 40S ribosomal protein S6 OS=Glossina morsitans morsitans GN=RpS6 PE=2 SV=1 PF01092 Ribosomal protein S6e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1646 40S ribosomal protein S6 Cluster-8309.65219 BF_2 1.00 1.37 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65233 BF_2 1.00 0.43 383 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65238 BF_2 1.00 0.55 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65250 BF_2 30.52 0.44 3209 91087141 XP_975282.1 3299 0.0e+00 PREDICTED: inactive dipeptidyl peptidase 10 [Tribolium castaneum]>gi|270009589|gb|EFA06037.1| hypothetical protein TcasGA2_TC008867 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N608 1084 1.7e-116 Inactive dipeptidyl peptidase 10 OS=Homo sapiens GN=DPP10 PE=1 SV=2 PF03721//PF00326//PF00930//PF05652//PF02129 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//Prolyl oligopeptidase family//Dipeptidyl peptidase IV (DPP IV) N-terminal region//Scavenger mRNA decapping enzyme (DcpS) N-terminal//X-Pro dipeptidyl-peptidase (S15 family) GO:0055114//GO:0000290//GO:0006508 oxidation-reduction process//deadenylation-dependent decapping of nuclear-transcribed mRNA//proteolysis GO:0016616//GO:0051287//GO:0016787//GO:0008236 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor//NAD binding//hydrolase activity//serine-type peptidase activity GO:0016020 membrane KOG2100 Dipeptidyl aminopeptidase Cluster-8309.65258 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65259 BF_2 5.21 0.37 869 546682251 ERL92212.1 277 4.3e-22 hypothetical protein D910_09532 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65264 BF_2 56.01 0.33 7415 546678803 ERL89348.1 899 2.7e-93 hypothetical protein D910_06719 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08845//PF13414//PF00515//PF13181//PF03842 Toxin SymE, type I toxin-antitoxin system//TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Silicon transporter GO:0015708//GO:0016070 silicate transport//RNA metabolic process GO:0016788//GO:0003723//GO:0005515 hydrolase activity, acting on ester bonds//RNA binding//protein binding GO:0005737 cytoplasm -- -- Cluster-8309.65269 BF_2 10.00 0.46 1204 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65270 BF_2 23.00 0.62 1848 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6528 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65296 BF_2 7.00 2.50 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65315 BF_2 9.00 1.16 611 115443591 YP_778610.1 181 4.1e-11 RNA polymerase beta subunit [Bigelowiella natans]>gi|122227441|sp|Q06J17.1|RPOB_BIGNA RecName: Full=DNA-directed RNA polymerase subunit beta; AltName: Full=PEP; AltName: Full=Plastid-encoded RNA polymerase subunit beta; Short=RNA polymerase subunit beta (chloroplast) [Bigelowiella natans]>gi|110810236|gb|ABG91442.1| RNA polymerase beta subunit [Bigelowiella natans] 761231856 KM881642.1 611 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C503 1030 6.0e-111 DNA-directed RNA polymerase subunit beta OS=Oryza sativa subsp. japonica GN=rpoB PE=3 SV=1 PF04561//PF04563 RNA polymerase Rpb2, domain 2//RNA polymerase beta subunit GO:0006144//GO:0006351//GO:0006206 purine nucleobase metabolic process//transcription, DNA-templated//pyrimidine nucleobase metabolic process GO:0003899//GO:0003677 DNA-directed RNA polymerase activity//DNA binding GO:0005730 nucleolus -- -- Cluster-8309.6532 BF_2 23.66 0.35 3076 642915789 XP_008200078.1 1770 1.1e-194 PREDICTED: uncharacterized protein LOC103314831 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00130 Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.65321 BF_2 7.94 0.33 1290 270001464 EEZ97911.1 986 3.9e-104 hypothetical protein TcasGA2_TC000296 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6PHZ8 604 3.2e-61 Kv channel-interacting protein 4 OS=Mus musculus GN=Kcnip4 PE=1 SV=1 PF13202//PF00036//PF04434//PF12763//PF13499//PF10591//PF13405//PF13833 EF hand//EF hand//SWIM zinc finger//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain//EF-hand domain pair GO:0007165 signal transduction GO:0005515//GO:0005509//GO:0008270 protein binding//calcium ion binding//zinc ion binding GO:0005578 proteinaceous extracellular matrix KOG0044 Ca2+ sensor (EF-Hand superfamily) Cluster-8309.6533 BF_2 19.33 0.36 2560 189238160 XP_001814766.1 394 3.4e-35 PREDICTED: zinc finger SWIM domain-containing protein 7 isoform X1 [Tribolium castaneum]>gi|270008721|gb|EFA05169.1| hypothetical protein TcasGA2_TC015298 [Tribolium castaneum] -- -- -- -- -- K04794 PTH2 peptidyl-tRNA hydrolase, PTH2 family http://www.genome.jp/dbget-bin/www_bget?ko:K04794 Q3ZBL5 190 6.4e-13 Peptidyl-tRNA hydrolase 2, mitochondrial OS=Bos taurus GN=PTRH2 PE=2 SV=1 PF01981//PF09243//PF04434 Peptidyl-tRNA hydrolase PTH2//Mitochondrial small ribosomal subunit Rsm22//SWIM zinc finger GO:0006412 translation GO:0004045//GO:0008168//GO:0008270 aminoacyl-tRNA hydrolase activity//methyltransferase activity//zinc ion binding -- -- KOG3282 Uncharacterized conserved protein Cluster-8309.65338 BF_2 24.13 2.20 746 91091098 XP_968555.1 250 5.0e-19 PREDICTED: ATP-binding cassette sub-family G member 5 [Tribolium castaneum]>gi|270014078|gb|EFA10526.1| hypothetical protein TcasGA2_TC012778 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0006200 obsolete ATP catabolic process GO:0005524//GO:0016887 ATP binding//ATPase activity -- -- -- -- Cluster-8309.6534 BF_2 5.52 0.71 613 642918175 XP_008191397.1 364 2.5e-32 PREDICTED: glycosyltransferase-like domain-containing protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VXN0 305 7.0e-27 Glycosyltransferase-like domain-containing protein 1-like OS=Drosophila melanogaster GN=CG15914 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65340 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65349 BF_2 1.00 0.37 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65351 BF_2 39.28 0.86 2196 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00220//PF14144 Neurohypophysial hormones, N-terminal Domain//Seed dormancy control GO:0006351//GO:0007218 transcription, DNA-templated//neuropeptide signaling pathway GO:0005185//GO:0043565 neurohypophyseal hormone activity//sequence-specific DNA binding GO:0005576 extracellular region -- -- Cluster-8309.65355 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65363 BF_2 7.00 1.66 463 826279431 XP_012494777.1 472 5.6e-45 PREDICTED: LOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform [Propithecus coquereli] 383087749 NG_012113.2 460 0 Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), RefSeqGene (LRG_310) on chromosome 3 K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 P32871 450 8.2e-44 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Bos taurus GN=PIK3CA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65370 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65371 BF_2 20.33 0.93 1200 861599125 KMQ83546.1 679 1.4e-68 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65372 BF_2 9.39 0.61 927 861599125 KMQ83546.1 255 1.6e-19 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01047//PF09339//PF01498 MarR family//IclR helix-turn-helix domain//Transposase GO:0006313//GO:0015074//GO:0006355 transposition, DNA-mediated//DNA integration//regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.65380 BF_2 77.80 1.17 3069 642935173 XP_008199677.1 206 2.6e-13 PREDICTED: elongation of very long chain fatty acids protein 7 [Tribolium castaneum]>gi|270014194|gb|EFA10642.1| hypothetical protein TcasGA2_TC016279 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A0JNC4 156 6.7e-09 Elongation of very long chain fatty acids protein 7 OS=Bos taurus GN=ELOVL7 PE=2 SV=1 PF01151//PF14750 GNS1/SUR4 family//Integrator complex subunit 2 -- -- -- -- GO:0032039//GO:0016021 integrator complex//integral component of membrane -- -- Cluster-8309.65394 BF_2 12.00 1.65 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65398 BF_2 2.00 0.37 511 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65406 BF_2 1.00 0.40 389 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65409 BF_2 18.00 1.12 957 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65421 BF_2 4.00 0.46 653 270004191 EFA00639.1 186 1.1e-11 hypothetical protein TcasGA2_TC003515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65442 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65447 BF_2 8.38 0.31 1430 642929422 XP_008195833.1 670 1.9e-67 PREDICTED: bromodomain adjacent to zinc finger domain protein 2B isoform X1 [Tribolium castaneum] 642929423 XM_008197612.1 78 2.79141e-30 PREDICTED: Tribolium castaneum bromodomain adjacent to zinc finger domain protein 2B (LOC663603), transcript variant X2, mRNA -- -- -- -- Q9DE13 303 2.8e-26 Bromodomain adjacent to zinc finger domain protein 2B OS=Gallus gallus GN=BAZ2B PE=2 SV=1 PF00439 Bromodomain -- -- GO:0005515 protein binding -- -- KOG1245 Chromatin remodeling complex WSTF-ISWI, large subunit (contains heterochromatin localization, PHD and BROMO domains) Cluster-8309.65466 BF_2 9.00 0.37 1304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65468 BF_2 52.51 0.56 4224 270004916 EFA01364.1 659 1.1e-65 hypothetical protein TcasGA2_TC010349 [Tribolium castaneum] -- -- -- -- -- K13915 LYZ lysozyme C http://www.genome.jp/dbget-bin/www_bget?ko:K13915 E1JI63 266 1.6e-21 Sensory neuron membrane protein 2 OS=Drosophila melanogaster GN=Snmp2 PE=2 SV=1 PF01130 CD36 family GO:0007155 cell adhesion -- -- GO:0016020 membrane -- -- Cluster-8309.65477 BF_2 23.00 0.56 2016 91080763 XP_967505.1 1360 2.6e-147 PREDICTED: otopetrin-2 isoform X2 [Tribolium castaneum]>gi|270005880|gb|EFA02328.1| hypothetical protein TcasGA2_TC007996 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80SX5 148 3.7e-08 Otopetrin-2 OS=Mus musculus GN=Otop2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG4740 Uncharacterized conserved protein Cluster-8309.65487 BF_2 27.00 0.38 3239 357610713 EHJ67109.1 149 1.1e-06 transposase [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65495 BF_2 27.00 0.55 2327 749755206 XP_011140074.1 578 1.4e-56 PREDICTED: nesprin-1 [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00435//PF01295 Spectrin repeat//Adenylate cyclase, class-I GO:0006171//GO:0006144 cAMP biosynthetic process//purine nucleobase metabolic process GO:0005515//GO:0004016 protein binding//adenylate cyclase activity -- -- -- -- Cluster-8309.65508 BF_2 43.00 3.30 833 324028132 ADY16617.1 1145 9.2e-123 ribosomal protein S3a [Fenneropenaeus merguiensis] 262401376 FJ774870.1 661 0 Scylla paramamosain S3Ae ribosomal protein-like protein mRNA, partial cds K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 Q6EV04 968 1.3e-103 40S ribosomal protein S3a OS=Biphyllus lunatus PE=2 SV=1 PF04083//PF05652//PF01015 Partial alpha/beta-hydrolase lipase region//Scavenger mRNA decapping enzyme (DcpS) N-terminal//Ribosomal S3Ae family GO:0042254//GO:0000290//GO:0006629//GO:0006412 ribosome biogenesis//deadenylation-dependent decapping of nuclear-transcribed mRNA//lipid metabolic process//translation GO:0003735//GO:0016787 structural constituent of ribosome//hydrolase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1628 40S ribosomal protein S3A Cluster-8309.65513 BF_2 53.00 5.53 688 262401117 ACY66461.1 724 5.0e-74 translationally controlled tumor protein [Scylla paramamosain] 262401116 FJ774739.1 531 0 Scylla paramamosain translationally controlled tumor protein mRNA, partial cds -- -- -- -- Q7QCK2 392 6.4e-37 Translationally-controlled tumor protein homolog OS=Anopheles gambiae GN=Tctp PE=3 SV=2 -- -- -- -- -- -- -- -- KOG1727 Microtubule-binding protein (translationally controlled tumor protein) Cluster-8309.65526 BF_2 30.69 0.83 1825 642925822 XP_008190442.1 400 4.9e-36 PREDICTED: uncharacterized protein LOC103312193 [Tribolium castaneum]>gi|270008612|gb|EFA05060.1| hypothetical protein TcasGA2_TC015155 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BXJ7 208 3.7e-15 Protein amnionless OS=Homo sapiens GN=AMN PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65535 BF_2 3.00 0.41 592 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65564 BF_2 9.00 0.64 880 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65569 BF_2 45.00 38.40 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6557 BF_2 3.00 0.32 675 546684414 ERL94061.1 154 6.1e-08 hypothetical protein D910_11344 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65570 BF_2 16.91 0.64 1393 91076706 XP_972155.1 856 5.0e-89 PREDICTED: peroxisome biogenesis factor 10 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- B1AUE5 312 2.5e-27 Peroxisome biogenesis factor 10 OS=Mus musculus GN=Pex10 PE=2 SV=1 PF16685//PF13639//PF14634//PF13371//PF12678//PF00097 zinc RING finger of MSL2//Ring finger domain//zinc-RING finger domain//Tetratricopeptide repeat//RING-H2 zinc finger//Zinc finger, C3HC4 type (RING finger) -- -- GO:0061630//GO:0046872//GO:0005515//GO:0008270 ubiquitin protein ligase activity//metal ion binding//protein binding//zinc ion binding -- -- KOG0317 Predicted E3 ubiquitin ligase, integral peroxisomal membrane protein Cluster-8309.65581 BF_2 4.00 0.38 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65582 BF_2 1.00 6.73 244 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65584 BF_2 3.00 0.31 692 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65585 BF_2 10.00 0.45 1221 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6561 BF_2 106.82 2.01 2505 189236336 XP_001816307.1 2221 4.7e-247 PREDICTED: general transcription factor IIH subunit 1 [Tribolium castaneum]>gi|270005862|gb|EFA02310.1| hypothetical protein TcasGA2_TC007976 [Tribolium castaneum] -- -- -- -- -- K03141 TFIIH1, GTF2H1, TFB1 transcription initiation factor TFIIH subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03141 Q960E8 1597 4.4e-176 General transcription factor IIH subunit 1 OS=Drosophila melanogaster GN=Tfb1 PE=2 SV=1 PF07289 Protein of unknown function (DUF1448) -- -- -- -- GO:0034464 BBSome KOG2074 RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH, subunit TFB1 Cluster-8309.65610 BF_2 1.00 0.85 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65630 BF_2 21.11 0.39 2549 91089303 XP_971648.1 2595 2.0e-290 PREDICTED: cationic amino acid transporter 4 isoform X1 [Tribolium castaneum]>gi|270012508|gb|EFA08956.1| hypothetical protein TcasGA2_TC006663 [Tribolium castaneum] -- -- -- -- -- K13866 SLC7A4 solute carrier family 7 (cationic amino acid transporter), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K13866 Q8BLQ7 1302 7.2e-142 Cationic amino acid transporter 4 OS=Mus musculus GN=Slc7a4 PE=2 SV=1 PF13520//PF00324 Amino acid permease//Amino acid permease GO:0055085//GO:0003333//GO:0006865//GO:0006810 transmembrane transport//amino acid transmembrane transport//amino acid transport//transport GO:0015171 amino acid transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane KOG1286 Amino acid transporters Cluster-8309.65631 BF_2 1.00 1.32 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05694 56kDa selenium binding protein (SBP56) -- -- GO:0008430 selenium binding -- -- -- -- Cluster-8309.6564 BF_2 1.00 0.53 362 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6565 BF_2 6.00 0.86 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65650 BF_2 1.00 0.33 415 642918194 XP_008191406.1 316 6.1e-27 PREDICTED: protein APCDD1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65652 BF_2 4.00 0.31 822 270003303 EEZ99750.1 384 1.6e-34 hypothetical protein TcasGA2_TC002519 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NCL9 209 1.3e-15 Protein APCDD1-like OS=Homo sapiens GN=APCDD1L PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.65661 BF_2 6.99 0.60 775 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65666 BF_2 6.00 1.36 472 434785 BAA03463.1 202 1.2e-13 actin [Procambarus clarkii] 724908519 XM_010380427.1 106 2.39261e-46 PREDICTED: Rhinopithecus roxellana actin, muscle-like (LOC104675775), transcript variant X2, mRNA K10354 ACTA1 actin, alpha skeletal muscle http://www.genome.jp/dbget-bin/www_bget?ko:K10354 P45521 202 4.8e-15 Actin (Fragment) OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8309.6567 BF_2 36.00 0.32 5033 270011681 EFA08129.1 2881 0.0e+00 hypothetical protein TcasGA2_TC005733 [Tribolium castaneum] 642932005 XM_008198594.1 320 2.97005e-164 PREDICTED: Tribolium castaneum kinesin 8B (LOC663478), mRNA K10401 KIF18_19 kinesin family member 18/19 http://www.genome.jp/dbget-bin/www_bget?ko:K10401 Q7ZXX2 1365 7.0e-149 Kinesin-like protein KIF19 OS=Xenopus laevis GN=kif19 PE=2 SV=1 PF00225//PF06009//PF06085//PF02931//PF02932 Kinesin motor domain//Laminin Domain II//Lipoprotein Rz1 precursor//Neurotransmitter-gated ion-channel ligand binding domain//Neurotransmitter-gated ion-channel transmembrane region GO:0006811//GO:0007155//GO:0007017//GO:0019064//GO:0006810//GO:0007018 ion transport//cell adhesion//microtubule-based process//fusion of virus membrane with host plasma membrane//transport//microtubule-based movement GO:0008017//GO:0005230//GO:0003777//GO:0005524 microtubule binding//extracellular ligand-gated ion channel activity//microtubule motor activity//ATP binding GO:0016020//GO:0045298//GO:0005874//GO:0019867 membrane//tubulin complex//microtubule//outer membrane KOG0242 Kinesin-like protein Cluster-8309.65691 BF_2 24.26 0.55 2137 115443558 YP_778577.1 970 4.6e-102 cytochrome b6 [Bigelowiella natans]>gi|115443565|ref|YP_778584.1| cytochrome b6 [Bigelowiella natans]>gi|122246280|sp|Q06J43.1|CYB6_BIGNA RecName: Full=Cytochrome b6 (chloroplast) [Bigelowiella natans]>gi|110810203|gb|ABG91409.1| cytochrome b6 [Bigelowiella natans]>gi|110810210|gb|ABG91416.1| cytochrome b6 [Bigelowiella natans] 761231605 KM881639.1 1521 0 Oryza glaberrima isolate 101328 chloroplast, complete genome K00412 CYTB, petB ubiquinol-cytochrome c reductase cytochrome b subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00412 P60162 1116 2.2e-120 Cytochrome b6 OS=Triticum aestivum GN=petB PE=3 SV=1 PF01292//PF13631//PF00032//PF00033 Prokaryotic cytochrome b561//Cytochrome b(N-terminal)/b6/petB//Cytochrome b(C-terminal)/b6/petD//Cytochrome b/b6/petB GO:0015979//GO:0022904//GO:0006118 photosynthesis//respiratory electron transport chain//obsolete electron transport GO:0016491//GO:0045158//GO:0005506//GO:0020037//GO:0009055 oxidoreductase activity//electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity//iron ion binding//heme binding//electron carrier activity GO:0016021//GO:0009535//GO:0016020 integral component of membrane//chloroplast thylakoid membrane//membrane KOG4663 Cytochrome b Cluster-8309.65696 BF_2 2.00 0.72 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65697 BF_2 11.00 0.60 1054 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65725 BF_2 7.00 3.21 376 328899855 AEB54651.1 472 4.5e-45 ribosomal protein S9 [Procambarus clarkii] -- -- -- -- -- K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 368 2.1e-34 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF00163//PF01022 Ribosomal protein S4/S9 N-terminal domain//Bacterial regulatory protein, arsR family GO:0006355 regulation of transcription, DNA-templated GO:0019843//GO:0003700 rRNA binding//transcription factor activity, sequence-specific DNA binding GO:0005622//GO:0005667 intracellular//transcription factor complex KOG3301 Ribosomal protein S4 Cluster-8309.65727 BF_2 3.00 1.86 350 328899855 AEB54651.1 441 1.7e-41 ribosomal protein S9 [Procambarus clarkii] 262401346 FJ774855.1 175 7.59589e-85 Scylla paramamosain ribosomal protein S9e mRNA, partial cds K02997 RP-S9e, RPS9 small subunit ribosomal protein S9e http://www.genome.jp/dbget-bin/www_bget?ko:K02997 P55935 414 9.2e-40 40S ribosomal protein S9 OS=Drosophila melanogaster GN=RpS9 PE=1 SV=2 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG3301 Ribosomal protein S4 Cluster-8309.65728 BF_2 17.64 0.36 2364 642939494 XP_008190865.1 477 7.5e-45 PREDICTED: indole-3-acetaldehyde oxidase-like [Tribolium castaneum]>gi|270016566|gb|EFA13012.1| hypothetical protein TcasGA2_TC001977 [Tribolium castaneum] -- -- -- -- -- K00106 XDH xanthine dehydrogenase/oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00106 Q6AUV1 267 6.9e-22 Xanthine dehydrogenase OS=Oryza sativa subsp. japonica GN=XDH PE=2 SV=1 PF01799//PF00941 [2Fe-2S] binding domain//FAD binding domain in molybdopterin dehydrogenase GO:0055114 oxidation-reduction process GO:0016491//GO:0046872//GO:0051536 oxidoreductase activity//metal ion binding//iron-sulfur cluster binding -- -- KOG0430 Xanthine dehydrogenase Cluster-8309.65752 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65762 BF_2 3.00 0.89 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65774 BF_2 59.00 0.73 3648 642921403 XP_008192852.1 2142 9.9e-238 PREDICTED: vesicular glutamate transporter 1 [Tribolium castaneum] 752878081 XM_011258205.1 70 2.02319e-25 PREDICTED: Camponotus floridanus vesicular glutamate transporter 1 (LOC105251400), mRNA K12302 SLC17A6_7_8 MFS transporter, ACS family, solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6/7/8 http://www.genome.jp/dbget-bin/www_bget?ko:K12302 Q05B21 1247 2.5e-135 Vesicular glutamate transporter 1 OS=Xenopus tropicalis GN=slc17a7 PE=2 SV=1 PF07690 Major Facilitator Superfamily GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane KOG2532 Permease of the major facilitator superfamily Cluster-8309.65781 BF_2 11.00 2.22 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65783 BF_2 3.00 0.34 653 270003330 EEZ99777.1 201 2.1e-13 hypothetical protein TcasGA2_TC002556 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65788 BF_2 11.00 0.33 1667 270006574 EFA03022.1 446 2.1e-41 hypothetical protein TcasGA2_TC010445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65790 BF_2 14.00 0.50 1450 270006574 EFA03022.1 865 4.7e-90 hypothetical protein TcasGA2_TC010445 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02532 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009539//GO:0009523 membrane//photosystem II reaction center//photosystem II -- -- Cluster-8309.6581 BF_2 9.00 0.37 1303 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65812 BF_2 13.59 0.95 887 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01692 Paramyxovirus non-structural protein C GO:0030683 evasion or tolerance by virus of host immune response -- -- -- -- -- -- Cluster-8309.65818 BF_2 1.00 0.38 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65819 BF_2 2.00 0.44 479 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6582 BF_2 10.00 0.33 1571 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65829 BF_2 16.00 0.47 1710 642917985 XP_008198971.1 1087 1.0e-115 PREDICTED: uncharacterized protein LOC103314498 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65835 BF_2 30.00 0.44 3110 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65841 BF_2 4.00 0.51 617 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65843 BF_2 1.00 1.63 294 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65845 BF_2 1.00 0.93 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65851 BF_2 4.00 0.84 487 432110945 ELK34419.1 781 8.7e-81 Phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha [Myotis davidii] 92446697 BC011791.1 487 0 Homo sapiens cDNA clone IMAGE:3959826, **** WARNING: chimeric clone **** K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 Q56JX8 769 8.8e-81 40S ribosomal protein S13 OS=Bos taurus GN=RPS13 PE=2 SV=3 PF00292//PF00312//PF08069 'Paired box' domain//Ribosomal protein S15//Ribosomal S13/S15 N-terminal domain GO:0006412//GO:0042254//GO:0006355 translation//ribosome biogenesis//regulation of transcription, DNA-templated GO:0003677//GO:0003735 DNA binding//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0400 40S ribosomal protein S13 Cluster-8309.65852 BF_2 2.00 0.41 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6586 BF_2 2.00 0.78 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65863 BF_2 33.92 0.45 3468 478262642 ENN81206.1 565 6.9e-55 hypothetical protein YQE_02396, partial [Dendroctonus ponderosae] -- -- -- -- -- K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 Q4V7Q6 336 1.0e-29 Serine/threonine-protein kinase ULK3 OS=Xenopus laevis GN=ulk3 PE=2 SV=1 PF08502//PF07714//PF03829//PF02740//PF00069//PF06293 LeuA allosteric (dimerisation) domain//Protein tyrosine kinase//PTS system glucitol/sorbitol-specific IIA component//Colipase, C-terminal domain//Protein kinase domain//Lipopolysaccharide kinase (Kdo/WaaP) family GO:0009401//GO:0006090//GO:0009099//GO:0009097//GO:0009098//GO:0006468//GO:0007586//GO:0016042//GO:0008643 phosphoenolpyruvate-dependent sugar phosphotransferase system//pyruvate metabolic process//valine biosynthetic process//isoleucine biosynthetic process//leucine biosynthetic process//protein phosphorylation//digestion//lipid catabolic process//carbohydrate transport GO:0005524//GO:0016773//GO:0008047//GO:0008982//GO:0004672//GO:0003852 ATP binding//phosphotransferase activity, alcohol group as acceptor//enzyme activator activity//protein-N(PI)-phosphohistidine-sugar phosphotransferase activity//protein kinase activity//2-isopropylmalate synthase activity GO:0009357//GO:0005737//GO:0005576//GO:0016020 protein-N(PI)-phosphohistidine-sugar phosphotransferase complex//cytoplasm//extracellular region//membrane -- -- Cluster-8309.6587 BF_2 39.00 4.68 636 332374630 AEE62456.1 656 3.5e-66 unknown [Dendroctonus ponderosae]>gi|478258539|gb|ENN78610.1| hypothetical protein YQE_04914, partial [Dendroctonus ponderosae]>gi|478261717|gb|ENN80874.1| hypothetical protein YQE_02710, partial [Dendroctonus ponderosae]>gi|546673698|gb|ERL85259.1| hypothetical protein D910_02680 [Dendroctonus ponderosae]>gi|546674332|gb|ERL85733.1| hypothetical protein D910_03148 [Dendroctonus ponderosae] 262401304 FJ774834.1 276 1.03131e-140 Scylla paramamosain ribosomal protein L19e mRNA, partial cds K02885 RP-L19e, RPL19 large subunit ribosomal protein L19e http://www.genome.jp/dbget-bin/www_bget?ko:K02885 P36241 638 1.8e-65 60S ribosomal protein L19 OS=Drosophila melanogaster GN=RpL19 PE=1 SV=2 PF01280 Ribosomal protein L19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1696 60s ribosomal protein L19 Cluster-8309.6588 BF_2 3.38 0.80 464 478257578 ENN77732.1 384 8.9e-35 hypothetical protein YQE_05803, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6590 BF_2 18.12 0.52 1733 719775592 XP_010220674.1 262 4.7e-20 PREDICTED: LOW QUALITY PROTEIN: activated CDC42 kinase 1-like [Tinamus guttatus] -- -- -- -- -- -- -- -- -- Q5U2X5 251 3.6e-20 Activated CDC42 kinase 1 OS=Rattus norvegicus GN=Tnk2 PE=2 SV=1 PF03117//PF00069//PF10576//PF07714//PF08923 UL49 family//Protein kinase domain//Iron-sulfur binding domain of endonuclease III//Protein tyrosine kinase//Mitogen-activated protein kinase kinase 1 interacting GO:0016032//GO:0032006//GO:0006468 viral process//regulation of TOR signaling//protein phosphorylation GO:0005524//GO:0051539//GO:0004672 ATP binding//4 iron, 4 sulfur cluster binding//protein kinase activity GO:0019033 viral tegument -- -- Cluster-8309.65906 BF_2 11.29 0.36 1615 91092970 XP_967107.1 1392 4.1e-151 PREDICTED: tektin-2 [Tribolium castaneum]>gi|270003167|gb|EEZ99614.1| hypothetical protein TcasGA2_TC002132 [Tribolium castaneum] -- -- -- -- -- K18629 TEKT2 tektin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K18629 Q26648 521 1.7e-51 Tektin-B1 OS=Strongylocentrotus purpuratus PE=1 SV=1 PF03938 Outer membrane protein (OmpH-like) GO:0000226 microtubule cytoskeleton organization GO:0051082 unfolded protein binding GO:0005874 microtubule -- -- Cluster-8309.65910 BF_2 4.66 0.37 818 642936848 XP_008197887.1 163 6.7e-09 PREDICTED: salivary glue protein Sgs-3-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.65912 BF_2 6.00 0.78 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.65919 BF_2 6.00 0.73 629 226489290 CAX75789.1 973 6.1e-103 Tubulin beta-2C chain [Schistosoma japonicum] 195487133 XM_002091745.1 314 7.65995e-162 Drosophila yakuba betaTub56D (Dyak\betaTub56D), partial mRNA K07375 TUBB tubulin beta http://www.genome.jp/dbget-bin/www_bget?ko:K07375 O17449 970 5.6e-104 Tubulin beta-1 chain OS=Manduca sexta PE=2 SV=1 PF00091 Tubulin/FtsZ family, GTPase domain -- -- GO:0003924 GTPase activity -- -- KOG1375 Beta tubulin Cluster-8309.65926 BF_2 2.00 0.82 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65929 BF_2 4.00 0.32 804 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6593 BF_2 85.00 2.68 1612 478255874 ENN76082.1 2237 4.2e-249 hypothetical protein YQE_07453, partial [Dendroctonus ponderosae]>gi|546680435|gb|ERL90701.1| hypothetical protein D910_08048 [Dendroctonus ponderosae] -- -- -- -- -- K12847 USP39, SAD1 U4/U6.U5 tri-snRNP-associated protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K12847 Q3TIX9 1750 5.1e-194 U4/U6.U5 tri-snRNP-associated protein 2 OS=Mus musculus GN=Usp39 PE=2 SV=2 PF00738//PF00443//PF02148 Polyhedrin//Ubiquitin carboxyl-terminal hydrolase//Zn-finger in ubiquitin-hydrolases and other protein GO:0016579 protein deubiquitination GO:0005198//GO:0036459//GO:0008270 structural molecule activity//ubiquitinyl hydrolase activity//zinc ion binding -- -- KOG2026 Spindle pole body protein - Sad1p Cluster-8309.6594 BF_2 71.90 3.41 1170 642936369 XP_008198411.1 769 5.1e-79 PREDICTED: transcription factor E2F5-like [Tribolium castaneum]>gi|270013125|gb|EFA09573.1| hypothetical protein TcasGA2_TC011687 [Tribolium castaneum] 572260333 XM_006608425.1 72 4.91618e-27 PREDICTED: Apis dorsata transcription factor E2F4-like (LOC102673706), transcript variant X2, mRNA K04682 E2F4_5 transcription factor E2F4/5 http://www.genome.jp/dbget-bin/www_bget?ko:K04682 Q62814 401 9.9e-38 Transcription factor E2F5 (Fragment) OS=Rattus norvegicus GN=E2f5 PE=2 SV=1 PF02319 E2F/DP family winged-helix DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2577 Transcription factor E2F/dimerization partner (TDP) Cluster-8309.65944 BF_2 4.00 0.37 745 321455048 EFX66193.1 158 2.3e-08 hypothetical protein DAPPUDRAFT_263528 [Daphnia pulex] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6595 BF_2 12.00 1.24 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65959 BF_2 3.00 0.45 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65967 BF_2 4.00 0.33 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65972 BF_2 3.00 2.40 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00789 UBX domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.65973 BF_2 1.00 1.03 317 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6598 BF_2 109.69 2.19 2378 861641895 KMQ93718.1 1428 4.0e-155 serine threonine-protein kinase 36 [Lasius niger] 817083926 XM_012409166.1 66 2.19677e-23 PREDICTED: Athalia rosae serine/threonine-protein kinase fused (LOC105690966), transcript variant X2, mRNA K06228 FU fused http://www.genome.jp/dbget-bin/www_bget?ko:K06228 P23647 867 1.9e-91 Serine/threonine-protein kinase fused OS=Drosophila melanogaster GN=fu PE=1 SV=2 PF10598//PF06293//PF00069//PF07714 RNA recognition motif of the spliceosomal PrP8//Lipopolysaccharide kinase (Kdo/WaaP) family//Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0016773//GO:0005524//GO:0003723 protein kinase activity//phosphotransferase activity, alcohol group as acceptor//ATP binding//RNA binding GO:0016020 membrane KOG0580 Serine/threonine protein kinase Cluster-8309.65980 BF_2 28.00 1.28 1200 122227452 Q06J66.1 1536 6.1e-168 RecName: Full=Photosystem II CP43 reaction center protein; AltName: Full=PSII 43 kDa protein; AltName: Full=Protein CP-43; Flags: Precursor>gi|110810187|gb|ABG91393.1| photosystem II 43 kDa protein [Bigelowiella natans] 761231605 KM881639.1 1155 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P0C367 1731 6.1e-192 Photosystem II CP43 reaction center protein OS=Oryza sativa subsp. japonica GN=psbC PE=3 SV=1 PF00421 Photosystem II protein GO:0018298//GO:0009772//GO:0019684//GO:0009767//GO:0006118 protein-chromophore linkage//photosynthetic electron transport in photosystem II//photosynthesis, light reaction//photosynthetic electron transport chain//obsolete electron transport GO:0045156//GO:0016168 electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity//chlorophyll binding GO:0009521//GO:0016021//GO:0009523//GO:0009535//GO:0030076//GO:0016020 photosystem//integral component of membrane//photosystem II//chloroplast thylakoid membrane//light-harvesting complex//membrane -- -- Cluster-8309.65981 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.65989 BF_2 6.77 0.39 1009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06151//PF08395 Trehalose receptor//7tm Chemosensory receptor GO:0050909//GO:0007187//GO:0050912//GO:0007607 sensory perception of taste//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//detection of chemical stimulus involved in sensory perception of taste//obsolete taste perception GO:0008527 taste receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.6599 BF_2 2.00 0.98 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.660 BF_2 3.00 3.51 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66028 BF_2 42.40 3.33 819 642927632 XP_008195342.1 514 1.3e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 6.5e-28 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF05706//PF00102//PF00782 Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase//Dual specificity phosphatase, catalytic domain GO:0006470//GO:0006570 protein dephosphorylation//tyrosine metabolic process GO:0004721//GO:0008138//GO:0004725 phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-8309.66033 BF_2 27.00 5.18 505 239505103 ACR78697.1 575 6.9e-57 40S ribosomal protein S20 [Rimicaris exoculata] 262401184 FJ774774.1 155 1.48389e-73 Scylla paramamosain 40S ribosomal protein S20 mRNA, partial cds K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 P23403 482 1.7e-47 40S ribosomal protein S20 OS=Xenopus laevis GN=rps20 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0900 40S ribosomal protein S20 Cluster-8309.66036 BF_2 3.00 3.72 307 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66044 BF_2 5.00 0.37 855 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66055 BF_2 19.00 1.52 810 761380084 YP_009121400.1 173 4.6e-10 NADH dehydrogenase subunit 4L (mitochondrion) [Thecamonas trahens]>gi|751130571|gb|AJF36649.1| NADH dehydrogenase subunit 4L (mitochondrion) [Thecamonas trahens] 528540458 AP012528.1 774 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- Q04614 235 1.2e-18 NADH-ubiquinone oxidoreductase chain 4L OS=Arabidopsis thaliana GN=ND4L PE=2 SV=2 PF02881//PF00420 SRP54-type protein, helical bundle domain//NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GO:0042773//GO:0006614//GO:0055114 ATP synthesis coupled electron transport//SRP-dependent cotranslational protein targeting to membrane//oxidation-reduction process GO:0005525//GO:0016651 GTP binding//oxidoreductase activity, acting on NAD(P)H -- -- -- -- Cluster-8309.6607 BF_2 4.70 0.39 788 91076992 XP_975474.1 551 6.6e-54 PREDICTED: ras-like protein 3 [Tribolium castaneum]>gi|270001761|gb|EEZ98208.1| hypothetical protein TcasGA2_TC000640 [Tribolium castaneum] 195387773 XM_002052531.1 48 7.17242e-14 Drosophila virilis GJ17614 (Dvir\GJ17614), mRNA K07855 RERG Ras-related and estrogen-regulated growth inhibitor http://www.genome.jp/dbget-bin/www_bget?ko:K07855 Q96A58 240 3.1e-19 Ras-related and estrogen-regulated growth inhibitor OS=Homo sapiens GN=RERG PE=1 SV=1 PF00071//PF07475//PF00158//PF03193//PF08477 Ras family//HPr Serine kinase C-terminal domain//Sigma-54 interaction domain//Protein of unknown function, DUF258//Ras of Complex, Roc, domain of DAPkinase GO:0000160//GO:0006109//GO:0016310//GO:0006355//GO:0006184//GO:0007264 phosphorelay signal transduction system//regulation of carbohydrate metabolic process//phosphorylation//regulation of transcription, DNA-templated//obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0000155//GO:0005524//GO:0008134//GO:0003924//GO:0005525//GO:0004672 phosphorelay sensor kinase activity//ATP binding//transcription factor binding//GTPase activity//GTP binding//protein kinase activity GO:0005667//GO:0009365//GO:0016020 transcription factor complex//protein histidine kinase complex//membrane KOG0395 Ras-related GTPase Cluster-8309.66080 BF_2 30.45 0.83 1829 189238680 XP_966563.2 1373 7.4e-149 PREDICTED: cytochrome P450 4C1-like [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1035 4.7e-111 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.66081 BF_2 35.99 0.79 2200 189238680 XP_966563.2 1373 8.8e-149 PREDICTED: cytochrome P450 4C1-like [Tribolium castaneum] -- -- -- -- -- K07427 CYP4V cytochrome P450, family 4, subfamily V http://www.genome.jp/dbget-bin/www_bget?ko:K07427 P29981 1035 5.7e-111 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0020037//GO:0005506 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//heme binding//iron ion binding -- -- -- -- Cluster-8309.66089 BF_2 3.00 0.34 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02070 Neuromedin U GO:0006940 regulation of smooth muscle contraction -- -- -- -- -- -- Cluster-8309.66090 BF_2 2.00 0.45 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66091 BF_2 41.99 0.46 4113 649572261 NP_001280507.1 1907 2.0e-210 5-hydroxytryptamine receptor 2C-like [Tribolium castaneum]>gi|642922007|ref|XP_008192980.1| PREDICTED: 5-hydroxytryptamine receptor 2C-like [Tribolium castaneum]>gi|270008193|gb|EFA04641.1| hypothetical protein TcasGA2_TC013979 [Tribolium castaneum]>gi|485836761|tpg|DAA64509.1| TPA_inf: CG1056-like serotonin receptor [Tribolium castaneum] 662203355 XM_008476790.1 63 1.7779e-21 PREDICTED: Diaphorina citri 5-hydroxytryptamine receptor 2B-like (LOC103512037), mRNA K04157 HTR2 5-hydroxytryptamine receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K04157 P24628 506 2.3e-49 D(2) dopamine receptor A OS=Xenopus laevis GN=drd2-a PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.66094 BF_2 1.00 0.52 365 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6610 BF_2 4.00 0.67 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66106 BF_2 1.00 1.59 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66109 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66122 BF_2 13.00 8.74 344 403311094 AFR34053.1 450 1.5e-42 NADH dehydrogenase subunit 3 (mitochondrion) [Scylla paramamosain] 403311088 JX457150.1 341 3.92092e-177 Scylla paramamosain mitochondrion, complete genome K03880 ND3 NADH-ubiquinone oxidoreductase chain 3 http://www.genome.jp/dbget-bin/www_bget?ko:K03880 P34850 283 1.4e-24 NADH-ubiquinone oxidoreductase chain 3 OS=Anopheles gambiae GN=mt:ND3 PE=3 SV=1 PF00507 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3 GO:0006814//GO:0006744//GO:0006120//GO:0055114//GO:0015992 sodium ion transport//ubiquinone biosynthetic process//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport GO:0008137 NADH dehydrogenase (ubiquinone) activity -- -- KOG4662 NADH dehydrogenase subunit 3 and related proteins Cluster-8309.66129 BF_2 5.00 0.44 760 91087377 XP_975644.1 398 3.5e-36 PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum]>gi|642929867|ref|XP_008196006.1| PREDICTED: cyclin-dependent kinases regulatory subunit [Tribolium castaneum] -- -- -- -- -- K02219 CKS1 cyclin-dependent kinase regulatory subunit CKS1 http://www.genome.jp/dbget-bin/www_bget?ko:K02219 Q91879 322 9.3e-29 Cyclin-dependent kinases regulatory subunit 2 OS=Xenopus laevis GN=cks2 PE=3 SV=1 PF01111 Cyclin-dependent kinase regulatory subunit GO:0045859//GO:0007049 regulation of protein kinase activity//cell cycle GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity -- -- KOG3484 Cyclin-dependent protein kinase CDC28, regulatory subunit CKS1, and related proteins Cluster-8309.66137 BF_2 4.00 0.38 726 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66149 BF_2 10.07 0.32 1590 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08072//PF05773 BDHCT (NUC031) domain//RWD domain GO:0006260 DNA replication GO:0005524//GO:0003677//GO:0016818//GO:0005515 ATP binding//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//protein binding GO:0005634 nucleus -- -- Cluster-8309.6615 BF_2 12.00 0.47 1351 642936661 XP_008198527.1 1009 8.8e-107 PREDICTED: uncharacterized protein LOC103314375 [Tribolium castaneum]>gi|270014170|gb|EFA10618.1| hypothetical protein TcasGA2_TC012880 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604//PF00018 Variant SH3 domain//SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.66163 BF_2 65.69 1.67 1937 91081315 XP_969699.1 1557 3.6e-170 PREDICTED: protein fuzzy homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q2HZX7 591 1.5e-59 Protein fuzzy homolog OS=Xenopus tropicalis GN=fuz PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66174 BF_2 2.00 0.32 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66179 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66180 BF_2 18.00 2.99 539 540849065 AGV15438.1 149 1.8e-07 metallothionein 2 [Portunus trituberculatus] 540849064 KC203334.1 267 8.71278e-136 Portunus trituberculatus metallothionein 2 (MT2) mRNA, complete cds -- -- -- -- P02805 153 2.6e-09 Metallothionein-1 OS=Scylla serrata PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66181 BF_2 3.10 3.56 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66222 BF_2 3.00 1.36 377 270011141 EFA07589.1 138 2.4e-06 hypothetical protein TcasGA2_TC030048, partial [Tribolium castaneum] 392303560 JX102593.1 267 5.9369e-136 Scylla paramamosain microsatellite Spm22 sequence -- -- -- -- -- -- -- -- PF02285 Cytochrome oxidase c subunit VIII GO:0015992//GO:0006123 proton transport//mitochondrial electron transport, cytochrome c to oxygen GO:0004129 cytochrome-c oxidase activity GO:0045277 respiratory chain complex IV -- -- Cluster-8309.66236 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66246 BF_2 2.00 0.59 428 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66253 BF_2 11.00 0.77 882 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66261 BF_2 24.00 5.28 477 262401367 ACY66586.1 754 1.1e-77 putative ribosomal protein S23e [Scylla paramamosain] 262401366 FJ774865.1 474 0 Scylla paramamosain putative ribosomal protein S23e mRNA, complete cds K02973 RP-S23e, RPS23 small subunit ribosomal protein S23e http://www.genome.jp/dbget-bin/www_bget?ko:K02973 Q86FP7 731 2.2e-76 40S ribosomal protein S23 OS=Dermacentor variabilis GN=RpS23 PE=2 SV=1 PF00164//PF09445 Ribosomal protein S12/S23//RNA cap guanine-N2 methyltransferase GO:0042254//GO:0001510//GO:0009452//GO:0006412 ribosome biogenesis//RNA methylation//7-methylguanosine RNA capping//translation GO:0008168//GO:0003735 methyltransferase activity//structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG1749 40S ribosomal protein S23 Cluster-8309.66276 BF_2 2.00 0.79 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66290 BF_2 2.00 0.39 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66297 BF_2 5.00 0.41 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66299 BF_2 23.95 6.41 443 557745704 AHA33382.1 522 8.5e-51 odorant-binding protein 1 [Batocera horsfieldi] 557745703 KC461118.1 294 6.92736e-151 Batocera horsfieldi odorant-binding protein 1 (obp1) mRNA, complete cds -- -- -- -- A7UR17 127 2.2e-06 General odorant-binding protein 72 (Fragment) OS=Anopheles gambiae GN=Obp72 PE=3 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.6630 BF_2 91.30 1.61 2655 642927615 XP_008195335.1 2050 3.4e-227 PREDICTED: ribosomal protein S6 kinase delta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R2S1 381 4.7e-35 Ribosomal protein S6 kinase-like 1 OS=Mus musculus GN=Rps6kl1 PE=1 SV=1 PF00787//PF00069//PF07714//PF13374//PF13181//PF00515//PF13414 PX domain//Protein kinase domain//Protein tyrosine kinase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//TPR repeat GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515//GO:0035091 ATP binding//protein kinase activity//protein binding//phosphatidylinositol binding -- -- -- -- Cluster-8309.66300 BF_2 35.05 3.73 680 557745704 AHA33382.1 759 4.3e-78 odorant-binding protein 1 [Batocera horsfieldi] 557745703 KC461118.1 429 0 Batocera horsfieldi odorant-binding protein 1 (obp1) mRNA, complete cds -- -- -- -- A7UR17 172 2.1e-11 General odorant-binding protein 72 (Fragment) OS=Anopheles gambiae GN=Obp72 PE=3 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.6631 BF_2 18.54 0.32 2711 642927615 XP_008195335.1 1805 8.8e-199 PREDICTED: ribosomal protein S6 kinase delta-1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96S38 355 5.0e-32 Ribosomal protein S6 kinase delta-1 OS=Homo sapiens GN=RPS6KC1 PE=1 SV=2 PF13414//PF07714//PF13374//PF13181//PF00515//PF00787//PF00069 TPR repeat//Protein tyrosine kinase//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//PX domain//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672//GO:0005515//GO:0035091 ATP binding//protein kinase activity//protein binding//phosphatidylinositol binding -- -- -- -- Cluster-8309.66310 BF_2 5.55 0.38 896 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66317 BF_2 4.00 1.60 390 584482884 AHJ09939.1 458 2.0e-43 glycoside hydrolase family 28 [Apriona japonica] -- -- -- -- -- -- -- -- -- Q9P358 259 9.6e-22 Endopolygalacturonase A OS=Aspergillus awamori GN=pgaA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66324 BF_2 18.72 0.46 2004 668460986 KFB48581.1 325 2.7e-27 AGAP007074-PA-like protein [Anopheles sinensis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01757 Acyltransferase family -- -- GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.66332 BF_2 34.00 1.10 1577 -- -- -- -- -- 761231605 KM881639.1 1574 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- P0C2Z1 266 6.0e-22 ATP synthase epsilon chain, chloroplastic OS=Oryza sativa GN=atpE PE=3 SV=1 PF08043 Xin repeat GO:0030036 actin cytoskeleton organization GO:0003779 actin binding GO:0030054 cell junction -- -- Cluster-8309.66347 BF_2 1.00 1.43 300 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66352 BF_2 3.00 0.51 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66387 BF_2 1.00 0.57 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66404 BF_2 18.37 1.02 1040 728416686 AIY68318.1 463 1.4e-43 esterase, partial [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- P12992 150 1.1e-08 Juvenile hormone esterase OS=Heliothis virescens PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66436 BF_2 9.00 0.59 927 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66438 BF_2 10.00 1.59 550 817063750 XP_012253590.1 204 7.9e-14 PREDICTED: excitatory amino acid transporter isoform X3 [Athalia rosae] -- -- -- -- -- K05613 SLC1A2, EAAT2 solute carrier family 1 (glial high affinity glutamate transporter), member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05613 P51906 162 2.4e-10 Excitatory amino acid transporter 3 OS=Mus musculus GN=Slc1a1 PE=1 SV=2 PF00375 Sodium:dicarboxylate symporter family GO:0006835//GO:0006812//GO:0006820 dicarboxylic acid transport//cation transport//anion transport GO:0017153 sodium:dicarboxylate symporter activity GO:0016020 membrane KOG3787 Glutamate/aspartate and neutral amino acid transporters Cluster-8309.6645 BF_2 25.00 0.38 3033 478250964 ENN71448.1 2669 6.4e-299 hypothetical protein YQE_11867, partial [Dendroctonus ponderosae] 572265044 XM_006610604.1 55 3.65957e-17 PREDICTED: Apis dorsata glucose dehydrogenase [FAD, quinone]-like (LOC102678750), transcript variant X2, mRNA -- -- -- -- P18172 1129 9.9e-122 Glucose dehydrogenase [FAD, quinone] OS=Drosophila pseudoobscura pseudoobscura GN=Gld PE=3 SV=4 PF05199//PF07992//PF05834//PF00732//PF01266 GMC oxidoreductase//Pyridine nucleotide-disulphide oxidoreductase//Lycopene cyclase protein//GMC oxidoreductase//FAD dependent oxidoreductase GO:0016117//GO:0055114 carotenoid biosynthetic process//oxidation-reduction process GO:0016705//GO:0016614//GO:0050660//GO:0016491 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//oxidoreductase activity, acting on CH-OH group of donors//flavin adenine dinucleotide binding//oxidoreductase activity -- -- -- -- Cluster-8309.66456 BF_2 1.00 0.48 371 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66457 BF_2 50.86 0.81 2906 546685576 ERL95063.1 2567 4.1e-287 hypothetical protein D910_12333 [Dendroctonus ponderosae] 564241862 XM_006277680.1 37 3.55443e-07 PREDICTED: Alligator mississippiensis REV1, polymerase (DNA directed) (REV1), transcript variant X3, mRNA K03515 REV1 DNA repair protein REV1 http://www.genome.jp/dbget-bin/www_bget?ko:K03515 Q4KWZ7 1026 8.3e-110 DNA repair protein REV1 OS=Gallus gallus GN=REV1 PE=2 SV=1 PF00817//PF11799//PF00961 impB/mucB/samB family//impB/mucB/samB family C-terminal domain//LAGLIDADG endonuclease GO:0006281 DNA repair GO:0004519//GO:0003684 endonuclease activity//damaged DNA binding -- -- KOG2093 Translesion DNA polymerase - REV1 deoxycytidyl transferase Cluster-8309.66460 BF_2 12.93 0.34 1878 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66463 BF_2 21.00 0.40 2459 642923542 XP_008193552.1 1258 2.1e-135 PREDICTED: probable G-protein coupled receptor Mth-like 3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BY15 168 2.2e-10 Adhesion G protein-coupled receptor E3 OS=Homo sapiens GN=ADGRE3 PE=2 SV=2 PF00002 7 transmembrane receptor (Secretin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.66466 BF_2 20.00 10.46 364 262401442 ACY66623.1 489 4.6e-47 ribosomal protein L44e [Scylla paramamosain] 262401441 FJ774903.1 364 0 Scylla paramamosain ribosomal protein L44e mRNA, complete cds K02929 RP-L44e, RPL44 large subunit ribosomal protein L44e http://www.genome.jp/dbget-bin/www_bget?ko:K02929 Q9NB33 375 3.2e-35 60S ribosomal protein L44 OS=Ochlerotatus triseriatus GN=RpL44 PE=3 SV=3 PF00935 Ribosomal protein L44 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3464 60S ribosomal protein L44 Cluster-8309.66470 BF_2 3.00 0.42 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66479 BF_2 6.00 0.48 805 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66485 BF_2 8.00 0.36 1229 861594808 KMQ83108.1 371 7.6e-33 transposable element tc3 transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13404//PF00126//PF01325//PF01047//PF01371//PF01418 AsnC-type helix-turn-helix domain//Bacterial regulatory helix-turn-helix protein, lysR family//Iron dependent repressor, N-terminal DNA binding domain//MarR family//Trp repressor protein//Helix-turn-helix domain, rpiR family GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677//GO:0043565 transcription factor activity, sequence-specific DNA binding//DNA binding//sequence-specific DNA binding GO:0005667//GO:0005622 transcription factor complex//intracellular -- -- Cluster-8309.66486 BF_2 4.00 0.88 477 609412429 4N6V 464 4.9e-44 Chain 2, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412430|pdb|4N6V|1 Chain 1, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412431|pdb|4N6V|9 Chain 9, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412432|pdb|4N6V|8 Chain 8, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412433|pdb|4N6V|7 Chain 7, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412434|pdb|4N6V|6 Chain 6, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412435|pdb|4N6V|4 Chain 4, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412436|pdb|4N6V|3 Chain 3, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412437|pdb|4N6V|0 Chain 0, Partial Rotational Order Disorder Structure Of Human Stefin B>gi|609412438|pdb|4N6V|5 Chain 5, Partial Rotational Order Disorder Structure Of Human Stefin B 371502129 NM_000100.3 477 0 Homo sapiens cystatin B (stefin B) (CSTB), mRNA K13907 CSTA_B cystatin-A/B http://www.genome.jp/dbget-bin/www_bget?ko:K13907 Q76LA0 464 2.0e-45 Cystatin-B OS=Gorilla gorilla gorilla GN=CSTB PE=3 SV=1 PF01221//PF00031 Dynein light chain type 1//Cystatin domain GO:0007017 microtubule-based process GO:0004869 cysteine-type endopeptidase inhibitor activity GO:0005875 microtubule associated complex -- -- Cluster-8309.66488 BF_2 5.00 0.31 965 546673251 ERL84892.1 402 1.5e-36 hypothetical protein D910_02315, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66500 BF_2 11.54 0.72 958 642935674 XP_974741.2 529 2.8e-51 PREDICTED: biogenesis of lysosome-related organelles complex 1 subunit 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1Z9S1 419 6.6e-40 Biogenesis of lysosome-related organelles complex 1 subunit 1 OS=Drosophila melanogaster GN=blos1 PE=1 SV=2 PF06320 GCN5-like protein 1 (GCN5L1) -- -- -- -- GO:0031083 BLOC-1 complex KOG3390 General control of amino-acid synthesis 5-like 1 Cluster-8309.66505 BF_2 12.00 1.48 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66507 BF_2 1.00 0.60 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66508 BF_2 12.26 0.43 1476 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6651 BF_2 58.42 0.32 7944 270010363 EFA06811.1 2473 9.0e-276 hypothetical protein TcasGA2_TC009753 [Tribolium castaneum] -- -- -- -- -- K05048 SLC6A15S solute carrier family 6 (neurotransmitter transporter, amino acid/orphan) member 15/16/17/18/20 http://www.genome.jp/dbget-bin/www_bget?ko:K05048 P31662 1331 9.8e-145 Sodium-dependent neutral amino acid transporter SLC6A17 OS=Rattus norvegicus GN=Slc6a17 PE=1 SV=1 PF00209 Sodium:neurotransmitter symporter family GO:0006836//GO:0006812 neurotransmitter transport//cation transport GO:0005328 neurotransmitter:sodium symporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.66513 BF_2 22.45 0.67 1688 642913126 XP_008201403.1 1632 6.3e-179 PREDICTED: neurotrimin isoform X3 [Tribolium castaneum] 768439803 XM_011563251.1 238 3.76715e-119 PREDICTED: Plutella xylostella lachesin-like (LOC105391717), transcript variant X2, mRNA -- -- -- -- Q99PJ0 343 7.6e-31 Neurotrimin OS=Mus musculus GN=Ntm PE=2 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- KOG3510 FOG: Immunoglobulin C-2 Type/fibronectin type III domains Cluster-8309.66523 BF_2 3.00 0.33 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66529 BF_2 4.00 0.69 531 795036951 XP_011865448.1 136 5.8e-06 PREDICTED: uncharacterized protein LOC105560706 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66537 BF_2 1.00 1.13 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66540 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66556 BF_2 3.00 0.67 473 861619004 KMQ86923.1 231 5.0e-17 mariner transposase [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66564 BF_2 2.00 0.31 557 -- -- -- -- -- 462283072 APGK01057067.1 43 2.9942e-11 Dendroctonus ponderosae Seq01057077, whole genome shotgun sequence -- -- -- -- -- -- -- -- PF02163 Peptidase family M50 GO:0006508 proteolysis GO:0004222 metalloendopeptidase activity -- -- -- -- Cluster-8309.66580 BF_2 5.00 2.80 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66583 BF_2 5.00 1.69 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66596 BF_2 32.29 1.26 1362 189234553 XP_973928.2 509 8.4e-49 PREDICTED: putative homeodomain transcription factor [Tribolium castaneum]>gi|270002071|gb|EEZ98518.1| hypothetical protein TcasGA2_TC001020 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V9A8 291 6.6e-25 Putative homeodomain transcription factor OS=Drosophila melanogaster GN=phtf PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.66598 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66602 BF_2 10.10 0.32 1612 756767050 AJM87404.1 2076 2.0e-230 voltage-sensitive sodium channel [Brassicogethes aeneus] 642910572 XM_008201786.1 780 0 PREDICTED: Tribolium castaneum paralytic A (Para), transcript variant X2, mRNA K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 Q9NY46 1163 6.0e-126 Sodium channel protein type 3 subunit alpha OS=Homo sapiens GN=SCN3A PE=1 SV=2 PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.66603 BF_2 2.00 0.44 475 675389751 KFM82648.1 405 3.4e-37 Protein LSM14-like protein, partial [Stegodyphus mimosarum] -- -- -- -- -- K18749 LSM14, RAP55, SCD6 protein LSM14 http://www.genome.jp/dbget-bin/www_bget?ko:K18749 Q3MHF8 367 3.5e-34 Protein LSM14 homolog A OS=Bos taurus GN=LSM14A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1073 Uncharacterized mRNA-associated protein RAP55 Cluster-8309.66608 BF_2 2.00 0.56 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6661 BF_2 2.00 0.54 441 307186921 EFN72307.1 151 8.8e-08 hypothetical protein EAG_00103, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66618 BF_2 7.04 0.35 1136 558231171 XP_006139245.1 402 1.8e-36 PREDICTED: uncharacterized protein LOC102453386 [Pelodiscus sinensis] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9XSR1 381 2.0e-35 Zinc finger protein 252 OS=Canis familiaris GN=ZNF252 PE=2 SV=1 PF00628//PF00096//PF13465 PHD-finger//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.6662 BF_2 43.00 1.39 1580 642923793 XP_008193885.1 720 3.3e-73 PREDICTED: uncharacterized protein LOC103313151 [Tribolium castaneum]>gi|270007744|gb|EFA04192.1| hypothetical protein TcasGA2_TC014441 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00096//PF07776 Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.66647 BF_2 12.28 0.38 1630 356483015 CCE46010.1 391 4.9e-35 putative DEAD-box ATP-dependent RNA helicase [Cancer pagurus] 356483014 HE608876.1 365 0 Cancer pagurus mRNA for putative DEAD-box ATP-dependent RNA helicase (ddx gene) K12823 DDX5, DBP2 ATP-dependent RNA helicase DDX5/DBP2 http://www.genome.jp/dbget-bin/www_bget?ko:K12823 Q4R6M5 285 3.9e-24 Probable ATP-dependent RNA helicase DDX5 OS=Macaca fascicularis GN=DDX5 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0331 ATP-dependent RNA helicase Cluster-8309.66656 BF_2 14.00 0.39 1774 -- -- -- -- -- 23380399 AY140650.1 218 5.1997e-108 Homarus americanus putative Na+/K+-ATPase alpha subunit mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66658 BF_2 28.93 0.33 4006 543335553 AGV55413.1 4602 0.0e+00 Na+/K+ ATPase [Penaeus monodon] 12044395 AF327439.1 3019 0 Callinectes sapidus gill Na+/K+ ATPase alpha subunit mRNA, complete cds K01539 ATP1A sodium/potassium-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K01539 P13607 4146 0.0e+00 Sodium/potassium-transporting ATPase subunit alpha OS=Drosophila melanogaster GN=Atpalpha PE=1 SV=3 PF00122//PF10716//PF00499 E1-E2 ATPase//NADH dehydrogenase transmembrane subunit//NADH-ubiquinone/plastoquinone oxidoreductase chain 6 GO:0015992//GO:0055114//GO:0006744//GO:0006118//GO:0006814//GO:0006120 proton transport//oxidation-reduction process//ubiquinone biosynthetic process//obsolete electron transport//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0046872//GO:0016655//GO:0000166 NADH dehydrogenase (ubiquinone) activity//metal ion binding//oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor//nucleotide binding -- -- KOG0203 Na+/K+ ATPase, alpha subunit Cluster-8309.6667 BF_2 2.00 0.38 509 795012860 XP_011880238.1 200 2.1e-13 PREDICTED: zinc finger BED domain-containing protein 1-like [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05699 hAT family C-terminal dimerisation region -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.66680 BF_2 9.00 0.51 1020 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66681 BF_2 9.59 0.48 1126 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66686 BF_2 3.75 0.33 756 642915229 XP_008190531.1 654 7.1e-66 PREDICTED: locomotion-related protein Hikaru genki [Tribolium castaneum] -- -- -- -- -- K17495 CSMD CUB and sushi domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K17495 Q09101 353 2.4e-32 Locomotion-related protein Hikaru genki OS=Drosophila melanogaster GN=hig PE=1 SV=2 PF02793 Hormone receptor domain GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016020 membrane -- -- Cluster-8309.66694 BF_2 1.00 0.39 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66712 BF_2 4.00 0.81 494 -- -- -- -- -- 768311753 CP010981.1 304 2.15038e-156 Verticillium dahliae VdLs.17 chromosome 2, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66718 BF_2 25.00 2.51 703 82795517 ABB91672.1 325 9.4e-28 arthrodial cuticle protein AMP13.4 [Callinectes sapidus] 82795516 DQ288147.1 79 3.72319e-31 Callinectes sapidus arthrodial cuticle protein AMP13.4 mRNA, complete cds -- -- -- -- P81578 320 1.5e-28 Cuticle protein AM1239 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.66719 BF_2 6.00 2.62 381 262401197 ACY66501.1 313 1.2e-26 60S acidic ribosomal protein P2 [Scylla paramamosain] 262401196 FJ774780.1 364 0 Scylla paramamosain 60S acidic ribosomal protein P2 mRNA, complete cds K02943 RP-LP2, RPLP2 large subunit ribosomal protein LP2 http://www.genome.jp/dbget-bin/www_bget?ko:K02943 P42037 165 7.4e-11 60S acidic ribosomal protein P2 OS=Alternaria alternata GN=ALTA5 PE=1 SV=1 PF03088 Strictosidine synthase GO:0009058//GO:0042432//GO:0016114 biosynthetic process//indole biosynthetic process//terpenoid biosynthetic process GO:0016844 strictosidine synthase activity -- -- KOG3449 60S acidic ribosomal protein P2 Cluster-8309.66720 BF_2 2.00 0.35 525 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66722 BF_2 2.00 0.95 373 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66740 BF_2 2.00 0.67 412 307196481 EFN78033.1 191 1.9e-12 hypothetical protein EAI_06421, partial [Harpegnathos saltator] 462330008 APGK01040161.1 59 2.76824e-20 Dendroctonus ponderosae Seq01040171, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66741 BF_2 4.00 1.53 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66757 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66759 BF_2 18.00 0.37 2311 642923044 XP_008200507.1 3157 0.0e+00 PREDICTED: neuroligin-4, X-linked-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8N0W4 840 2.4e-88 Neuroligin-4, X-linked OS=Homo sapiens GN=NLGN4X PE=1 SV=1 PF07859//PF14991//PF00898 alpha/beta hydrolase fold//Protein melan-A//Orbivirus outer capsid protein VP2 GO:0008152 metabolic process GO:0005198//GO:0016787 structural molecule activity//hydrolase activity GO:0042470//GO:0019028 melanosome//viral capsid KOG1516 Carboxylesterase and related proteins Cluster-8309.66764 BF_2 11.00 0.53 1157 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66767 BF_2 1.00 0.39 393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.66772 BF_2 6.00 1.69 435 115443587 YP_778606.1 187 5.8e-12 photosystem II protein H [Bigelowiella natans]>gi|122227444|sp|Q06J21.1|PSBH_BIGNA RecName: Full=Photosystem II reaction center protein H; Short=PSII-H; AltName: Full=Photosystem II 10 kDa phosphoprotein (chloroplast) [Bigelowiella natans]>gi|110810232|gb|ABG91438.1| photosystem II protein H [Bigelowiella natans] 761231940 KM881643.1 390 0 Oryza officinalis chloroplast, complete genome -- -- -- -- P0C422 362 1.2e-33 Photosystem II reaction center protein H OS=Oryza sativa subsp. japonica GN=psbH PE=3 SV=1 PF00737 Photosystem II 10 kDa phosphoprotein GO:0050821//GO:0015979 protein stabilization//photosynthesis GO:0042301 phosphate ion binding GO:0009523//GO:0009535//GO:0016020//GO:0016021 photosystem II//chloroplast thylakoid membrane//membrane//integral component of membrane -- -- Cluster-8309.6684 BF_2 8.00 0.53 914 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.669 BF_2 7.00 0.44 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6693 BF_2 7.00 0.61 767 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6710 BF_2 25.00 0.79 1613 237825144 ACR20475.1 530 3.7e-51 mannose-binding protein [Procambarus clarkii] 284520579 GU353177.1 64 1.91388e-22 Eriocheir sinensis mannose-binding protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6711 BF_2 134.83 2.76 2332 642913117 XP_008201398.1 1808 3.4e-199 PREDICTED: uncharacterized protein LOC663672 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8IZW8 167 2.7e-10 Tensin-4 OS=Homo sapiens GN=TNS4 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6712 BF_2 1.00 0.58 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6714 BF_2 6.00 0.45 847 554554011 XP_005871471.1 1315 1.8e-142 PREDICTED: 40S ribosomal protein S3a [Myotis brandtii] 694909173 XM_001153182.4 847 0 PREDICTED: Pan troglodytes 40S ribosomal protein S3a {ECO:0000255|HAMAP-Rule:MF_03122} (LOC461536), mRNA K02984 RP-S3Ae, RPS3A small subunit ribosomal protein S3Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02984 P61247 1305 1.1e-142 40S ribosomal protein S3a OS=Homo sapiens GN=RPS3A PE=1 SV=2 PF04083//PF01408//PF01015 Partial alpha/beta-hydrolase lipase region//Oxidoreductase family, NAD-binding Rossmann fold//Ribosomal S3Ae family GO:0042254//GO:0006412//GO:0006629 ribosome biogenesis//translation//lipid metabolic process GO:0003735//GO:0016491 structural constituent of ribosome//oxidoreductase activity GO:0005840//GO:0005622 ribosome//intracellular KOG1628 40S ribosomal protein S3A Cluster-8309.6716 BF_2 8.25 0.31 1413 780122407 XP_011678094.1 474 1.0e-44 PREDICTED: RNA-directed DNA polymerase from mobile element jockey-like [Strongylocentrotus purpuratus] 218156961 FJ439606.1 188 1.95811e-91 Scylla serrata clone SSF6 microsatellite sequence -- -- -- -- Q9NBX4 184 1.7e-12 Probable RNA-directed DNA polymerase from transposon X-element OS=Drosophila melanogaster GN=X-element\ORF2 PE=3 SV=1 PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.6726 BF_2 36.00 4.01 663 766937328 XP_011501111.1 860 8.2e-90 PREDICTED: 40S ribosomal protein S8 [Ceratosolen solmsi marchali] 70909498 AM048936.1 122 4.37091e-55 Carabus granulatus partial mRNA for ribosomal protein S8e (rpS8e gene) K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 O76756 848 8.3e-90 40S ribosomal protein S8 OS=Apis mellifera GN=RpS8 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG3283 40S ribosomal protein S8 Cluster-8309.6735 BF_2 2.00 0.33 544 270013462 EFA09910.1 368 7.5e-33 hypothetical protein TcasGA2_TC012061 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.6738 BF_2 1.00 0.55 360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6745 BF_2 84.00 2.44 1726 568983990 XP_006517560.1 307 2.8e-25 PREDICTED: zinc finger protein 431-like isoform X2 [Mus musculus] -- -- -- -- -- -- -- -- -- Q8NDP4 297 1.7e-25 Zinc finger protein 439 OS=Homo sapiens GN=ZNF439 PE=1 SV=1 PF13465//PF00096//PF13912//PF16622//PF07776 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger//zinc-finger C2H2-type//Zinc-finger associated domain (zf-AD) -- -- GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.675 BF_2 2.00 0.33 540 478250070 ENN70576.1 409 1.3e-37 hypothetical protein YQE_12751, partial [Dendroctonus ponderosae] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P36513 265 2.7e-22 UDP-glucuronosyltransferase 2B14 OS=Oryctolagus cuniculus GN=UGT2B14 PE=2 SV=1 PF00201//PF04101 UDP-glucoronosyl and UDP-glucosyl transferase//Glycosyltransferase family 28 C-terminal domain GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.6750 BF_2 2.66 0.98 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6753 BF_2 3.00 0.31 697 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6761 BF_2 4.73 1.20 451 478260414 ENN80151.1 240 4.3e-18 hypothetical protein YQE_03415, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6768 BF_2 10.81 0.83 834 91079939 XP_968354.1 359 1.3e-31 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003259|gb|EEZ99706.1| hypothetical protein TcasGA2_TC002467 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 O09159 200 1.4e-14 Lysosomal alpha-mannosidase OS=Mus musculus GN=Man2b1 PE=2 SV=4 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0005975//GO:0006013 carbohydrate metabolic process//mannose metabolic process GO:0015923//GO:0004553//GO:0005488 mannosidase activity//hydrolase activity, hydrolyzing O-glycosyl compounds//binding -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.6769 BF_2 3.00 0.33 663 91076462 XP_971946.1 587 3.7e-58 PREDICTED: protein trunk [Tribolium castaneum]>gi|270002904|gb|EEZ99351.1| trunk [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q24155 377 3.4e-35 Protein trunk OS=Drosophila melanogaster GN=trk PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6772 BF_2 5.22 0.42 803 91081763 XP_973188.1 496 1.6e-47 PREDICTED: UDP-glucuronosyltransferase 2B20 [Tribolium castaneum]>gi|270005052|gb|EFA01500.1| hypothetical protein TcasGA2_TC007056 [Tribolium castaneum] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q88168 372 1.6e-34 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.6773 BF_2 6.78 0.50 856 817074395 XP_012259384.1 338 3.6e-29 PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase-like [Athalia rosae] -- -- -- -- -- K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 Q88168 296 1.1e-25 Ecdysteroid UDP-glucosyltransferase OS=Spodoptera littoralis nuclear polyhedrosis virus GN=EGT PE=3 SV=1 PF04101//PF00201 Glycosyltransferase family 28 C-terminal domain//UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8309.6777 BF_2 16.00 1.42 759 646699579 KDR10133.1 329 3.5e-28 cAMP-responsive element-binding protein-like 2 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- O60519 269 1.3e-22 cAMP-responsive element-binding protein-like 2 OS=Homo sapiens GN=CREBL2 PE=1 SV=1 PF07716//PF00170 Basic region leucine zipper//bZIP transcription factor GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.6782 BF_2 16.37 0.33 2350 189239551 XP_975637.2 1459 1.0e-158 PREDICTED: proton-coupled folate transporter [Tribolium castaneum]>gi|270009516|gb|EFA05964.1| hypothetical protein TcasGA2_TC008783 [Tribolium castaneum] -- -- -- -- -- K14613 SLC46A1_3 MFS transporter, PCFT/HCP family, solute carrier family 46 (folate transporter), member 1/3 http://www.genome.jp/dbget-bin/www_bget?ko:K14613 Q6DCX5 199 5.3e-14 Proton-coupled folate transporter OS=Xenopus laevis GN=slc46a1 PE=2 SV=1 PF07690//PF06667 Major Facilitator Superfamily//Phage shock protein B GO:0009271//GO:0055085//GO:0006355 phage shock//transmembrane transport//regulation of transcription, DNA-templated -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.6795 BF_2 16.00 0.51 1610 297251407 ADI24987.1 1941 8.9e-215 chitin deacetylase 1 precursor [Cherax quadricarinatus] 121484227 EF102018.1 591 0 Portunus pelagicus vermiform cuticle protein VER1 mRNA, complete cds -- -- -- -- -- -- -- -- PF00642//PF02879//PF01607 Zinc finger C-x8-C-x5-C-x3-H type (and similar)//Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II//Chitin binding Peritrophin-A domain GO:0006030//GO:0005975 chitin metabolic process//carbohydrate metabolic process GO:0046872//GO:0008061 metal ion binding//chitin binding GO:0005576 extracellular region -- -- Cluster-8309.6798 BF_2 10.00 0.63 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01080//PF15550//PF15748 Presenilin//Draxin//Centriole, cilia and spindle-associated GO:0016055//GO:0007411 Wnt signaling pathway//axon guidance GO:0004190 aspartic-type endopeptidase activity GO:0005856//GO:0016021//GO:0005576 cytoskeleton//integral component of membrane//extracellular region -- -- Cluster-8309.68 BF_2 1.00 0.32 416 -- -- -- -- -- 19386775 AP003537.3 375 0 Oryza sativa Japonica Group genomic DNA, chromosome 1, BAC clone:B1140D12 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6801 BF_2 1.00 0.87 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6803 BF_2 6.00 0.49 799 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6808 BF_2 4.00 0.61 563 642913366 XP_001808512.2 267 4.0e-21 PREDICTED: uncharacterized protein LOC100141657 isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6811 BF_2 21.00 3.80 518 328899546 AEB54640.1 455 5.8e-43 ribosomal protein L24 [Procambarus clarkii] -- -- -- -- -- K02896 RP-L24e, RPL24 large subunit ribosomal protein L24e http://www.genome.jp/dbget-bin/www_bget?ko:K02896 Q962T5 372 1.0e-34 60S ribosomal protein L24 OS=Spodoptera frugiperda GN=RpL24 PE=2 SV=1 PF02932//PF07565//PF01080//PF03222 Neurotransmitter-gated ion-channel transmembrane region//Band 3 cytoplasmic domain//Presenilin//Tryptophan/tyrosine permease family GO:0003333//GO:0006820//GO:0006811 amino acid transmembrane transport//anion transport//ion transport GO:0008509//GO:0004190 anion transmembrane transporter activity//aspartic-type endopeptidase activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG1722 60s ribosomal protein L24 Cluster-8309.6813 BF_2 13.00 1.22 732 332846699 XP_001140497.2 913 6.4e-96 PREDICTED: 60S ribosomal protein L13 [Pan troglodytes] 341604764 NM_000977.3 732 0 Homo sapiens ribosomal protein L13 (RPL13), transcript variant 1, mRNA K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 P26373 914 2.0e-97 60S ribosomal protein L13 OS=Homo sapiens GN=RPL13 PE=1 SV=4 PF01294 Ribosomal protein L13e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3295 60S Ribosomal protein L13 Cluster-8309.6818 BF_2 7.00 1.00 580 807039402 XP_012160763.1 348 1.7e-30 PREDICTED: muscle LIM protein Mlp84B isoform X1 [Ceratitis capitata] -- -- -- -- -- K09377 CSRP cysteine and glycine-rich protein http://www.genome.jp/dbget-bin/www_bget?ko:K09377 Q24400 331 6.4e-30 Muscle LIM protein Mlp84B OS=Drosophila melanogaster GN=Mlp84B PE=1 SV=1 PF00412 LIM domain -- -- GO:0008270 zinc ion binding -- -- KOG1700 Regulatory protein MLP and related LIM proteins Cluster-8309.6821 BF_2 6.00 0.80 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6822 BF_2 44.00 1.71 1364 332373342 AEE61812.1 982 1.2e-103 unknown [Dendroctonus ponderosae] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q9W092 661 8.2e-68 Probable chitinase 2 OS=Drosophila melanogaster GN=Cht2 PE=1 SV=1 PF00704 Glycosyl hydrolases family 18 GO:0005975 carbohydrate metabolic process GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds -- -- -- -- Cluster-8309.6827 BF_2 29.00 2.89 707 6831612 Q9XYC2.3 865 2.3e-90 RecName: Full=60S ribosomal protein L15 [Orconectes limosus]>gi|4530186|gb|AAD21924.1| L15-like ribosomal protein [Orconectes limosus] 31322597 AY249411.1 144 2.75552e-67 Anguilla japonica ribosomal protein L15 (rpl15) mRNA, complete cds K02877 RP-L15e, RPL15 large subunit ribosomal protein L15e http://www.genome.jp/dbget-bin/www_bget?ko:K02877 Q9XYC2 865 9.4e-92 60S ribosomal protein L15 OS=Orconectes limosus GN=RPL15 PE=2 SV=3 PF00827 Ribosomal L15 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1678 60s ribosomal protein L15 Cluster-8309.6831 BF_2 40.07 0.73 2569 642920067 XP_008192192.1 640 1.0e-63 PREDICTED: nuclear RNA export factor 2-like [Tribolium castaneum]>gi|270005996|gb|EFA02444.1| hypothetical protein TcasGA2_TC008131 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9GZY0 309 1.0e-26 Nuclear RNA export factor 2 OS=Homo sapiens GN=NXF2 PE=1 SV=1 PF02136//PF13855//PF03943 Nuclear transport factor 2 (NTF2) domain//Leucine rich repeat//TAP C-terminal domain GO:0051028//GO:0006810 mRNA transport//transport GO:0005515 protein binding GO:0005634//GO:0005622 nucleus//intracellular KOG3763 mRNA export factor TAP/MEX67 Cluster-8309.6833 BF_2 26.00 4.22 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6843 BF_2 27.00 1.26 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6845 BF_2 8.95 0.58 932 817059119 XP_012251055.1 980 1.4e-103 PREDICTED: acetylcholine receptor subunit beta-like 2 [Athalia rosae] 584600389 KF873592.1 247 2.03273e-124 Locusta migratoria strain Js nicotinic acetylcholine receptor alpha8 variant D mRNA, complete cds, alternatively spliced K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P25162 935 9.5e-100 Acetylcholine receptor subunit beta-like 2 OS=Drosophila melanogaster GN=nAChRbeta2 PE=2 SV=3 PF02931//PF02427 Neurotransmitter-gated ion-channel ligand binding domain//Photosystem I reaction centre subunit IV / PsaE GO:0015979//GO:0006810//GO:0006811 photosynthesis//transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0009538//GO:0016020//GO:0009522 photosystem I reaction center//membrane//photosystem I KOG3645 Acetylcholine receptor Cluster-8309.6847 BF_2 8.56 0.32 1420 642938493 XP_008198006.1 284 1.1e-22 PREDICTED: nose resistant to fluoxetine protein 6-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6850 BF_2 7.85 0.56 879 642926052 XP_970129.2 599 2.0e-59 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P49638 194 7.5e-14 Alpha-tocopherol transfer protein OS=Homo sapiens GN=TTPA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.6865 BF_2 9.40 1.16 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.6872 BF_2 2.00 0.49 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6875 BF_2 27.30 0.48 2644 751231572 XP_011169356.1 1074 5.0e-114 PREDICTED: uncharacterized protein LOC105202492 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184//PF05225//PF06308 DDE superfamily endonuclease//helix-turn-helix, Psq domain//23S rRNA methylase leader peptide (ErmC) GO:0046677 response to antibiotic GO:0003676//GO:0003677 nucleic acid binding//DNA binding -- -- -- -- Cluster-8309.6876 BF_2 14.37 0.40 1785 642932421 XP_972642.2 1794 1.1e-197 PREDICTED: synaptotagmin-15 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P59926 550 8.0e-55 Synaptotagmin-15 OS=Rattus norvegicus GN=Syt15 PE=2 SV=1 PF01299//PF00168 Lysosome-associated membrane glycoprotein (Lamp)//C2 domain -- -- GO:0005515 protein binding GO:0016020 membrane KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.6891 BF_2 2.00 0.34 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6896 BF_2 2.00 0.89 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.69 BF_2 1.00 0.53 363 -- -- -- -- -- 32488733 AL606655.3 341 4.16047e-177 Oryza sativa genomic DNA, chromosome 4, BAC clone: OSJNBb0040D15, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6904 BF_2 5.00 0.50 705 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6907 BF_2 6.57 0.31 1182 270009426 EFA05874.1 296 3.7e-24 hypothetical protein TcasGA2_TC008683 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF11045 Putative inner membrane protein of Enterobacteriaceae -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.6909 BF_2 36.98 1.82 1136 817212892 XP_012282645.1 439 9.2e-41 PREDICTED: pyridoxine-5'-phosphate oxidase-like isoform X2 [Orussus abietinus] -- -- -- -- -- -- -- -- -- Q487G8 254 1.1e-20 Pyridoxine/pyridoxamine 5'-phosphate oxidase OS=Colwellia psychrerythraea (strain 34H / ATCC BAA-681) GN=pdxH PE=3 SV=1 PF01243//PF12766//PF04420//PF10590 Pyridoxamine 5'-phosphate oxidase//Pyridoxamine 5'-phosphate oxidase//CHD5-like protein//Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region GO:0055114//GO:0008615//GO:0071816 oxidation-reduction process//pyridoxine biosynthetic process//tail-anchored membrane protein insertion into ER membrane GO:0004733//GO:0016638//GO:0010181 pyridoxamine-phosphate oxidase activity//oxidoreductase activity, acting on the CH-NH2 group of donors//FMN binding -- -- KOG2586 Pyridoxamine-phosphate oxidase Cluster-8309.6913 BF_2 12.00 0.41 1498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03650 Uncharacterised protein family (UPF0041) GO:0006850 mitochondrial pyruvate transport -- -- GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.6914 BF_2 2.00 0.87 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04188 Mannosyltransferase (PIG-V) GO:0006506 GPI anchor biosynthetic process GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity GO:0000136 alpha-1,6-mannosyltransferase complex -- -- Cluster-8309.6916 BF_2 5.10 0.70 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6917 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6920 BF_2 7.00 0.47 905 646706235 KDR13572.1 738 1.6e-75 hypothetical protein L798_12353 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6922 BF_2 97.08 2.27 2073 91094101 XP_967213.1 1872 1.1e-206 PREDICTED: tubulin--tyrosine ligase-like protein 12 [Tribolium castaneum]>gi|270010885|gb|EFA07333.1| hypothetical protein TcasGA2_TC015929 [Tribolium castaneum] -- -- -- -- -- K16609 TTLL12 tubulin--tyrosine ligase-like protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K16609 Q14166 1204 1.4e-130 Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens GN=TTLL12 PE=1 SV=2 PF03133//PF04120 Tubulin-tyrosine ligase family//Low affinity iron permease GO:0055085//GO:0006464 transmembrane transport//cellular protein modification process -- -- -- -- KOG2155 Tubulin-tyrosine ligase-related protein Cluster-8309.6923 BF_2 11.92 0.59 1127 91094101 XP_967213.1 419 1.9e-38 PREDICTED: tubulin--tyrosine ligase-like protein 12 [Tribolium castaneum]>gi|270010885|gb|EFA07333.1| hypothetical protein TcasGA2_TC015929 [Tribolium castaneum] -- -- -- -- -- K16609 TTLL12 tubulin--tyrosine ligase-like protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K16609 Q14166 220 9.3e-17 Tubulin--tyrosine ligase-like protein 12 OS=Homo sapiens GN=TTLL12 PE=1 SV=2 PF01031 Dynamin central region -- -- GO:0005525 GTP binding -- -- KOG2155 Tubulin-tyrosine ligase-related protein Cluster-8309.6936 BF_2 18.05 0.31 2703 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6937 BF_2 27.11 0.42 2992 91078258 XP_970899.1 943 8.7e-99 PREDICTED: conserved oligomeric Golgi complex subunit 6 [Tribolium castaneum]>gi|270003921|gb|EFA00369.1| hypothetical protein TcasGA2_TC003211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V564 761 4.6e-79 Conserved oligomeric Golgi complex subunit 6 OS=Drosophila melanogaster GN=CG1968 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3758 Uncharacterized conserved protein Cluster-8309.6940 BF_2 1.13 0.72 348 91083149 XP_971578.1 141 1.0e-06 PREDICTED: venom protease-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6941 BF_2 2.00 2.25 312 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01356 Alpha amylase inhibitor -- -- GO:0015066 alpha-amylase inhibitor activity -- -- -- -- Cluster-8309.6944 BF_2 2.00 0.43 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6947 BF_2 30.88 0.39 3561 642916919 XP_008199554.1 1572 1.2e-171 PREDICTED: F-box/LRR-repeat protein 16 [Tribolium castaneum] 642916918 XM_008201332.1 373 0 PREDICTED: Tribolium castaneum F-box/LRR-repeat protein 16 (LOC660141), mRNA K10282 FBXL16 F-box and leucine-rich repeat protein 16 http://www.genome.jp/dbget-bin/www_bget?ko:K10282 A2RT62 1122 7.5e-121 F-box/LRR-repeat protein 16 OS=Mus musculus GN=Fbxl16 PE=2 SV=1 PF00560//PF03876//PF13855//PF13516 Leucine Rich Repeat//SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397//Leucine rich repeat//Leucine Rich repeat GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0005515//GO:0003899 protein binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG3297 DNA-directed RNA polymerase subunit E' Cluster-8309.695 BF_2 33.00 1.00 1662 113206044 NP_001038094.1 1413 1.5e-153 chitinase 8 precursor [Tribolium castaneum]>gi|109895308|gb|ABG47446.1| chitinase 8 [Tribolium castaneum]>gi|270010245|gb|EFA06693.1| hypothetical protein TcasGA2_TC009624 [Tribolium castaneum] -- -- -- -- -- K01183 E3.2.1.14 chitinase http://www.genome.jp/dbget-bin/www_bget?ko:K01183 Q91XA9 831 1.9e-87 Acidic mammalian chitinase OS=Mus musculus GN=Chia PE=1 SV=2 PF03549//PF00704//PF01607//PF02135 Translocated intimin receptor (Tir) intimin-binding domain//Glycosyl hydrolases family 18//Chitin binding Peritrophin-A domain//TAZ zinc finger GO:0006355//GO:0005975//GO:0006030//GO:0042967//GO:0071704 regulation of transcription, DNA-templated//carbohydrate metabolic process//chitin metabolic process//acyl-carrier-protein biosynthetic process//organic substance metabolic process GO:0008270//GO:0003712//GO:0016798//GO:0004553//GO:0008061//GO:0005515//GO:0004402 zinc ion binding//transcription cofactor activity//hydrolase activity, acting on glycosyl bonds//hydrolase activity, hydrolyzing O-glycosyl compounds//chitin binding//protein binding//histone acetyltransferase activity GO:0005576//GO:0000123//GO:0005634//GO:0005667 extracellular region//histone acetyltransferase complex//nucleus//transcription factor complex -- -- Cluster-8309.6950 BF_2 11.00 0.50 1203 270013588 EFA10036.1 148 5.4e-07 hypothetical protein TcasGA2_TC012208 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6951 BF_2 20.00 0.51 1931 91090700 XP_974799.1 1080 7.3e-115 PREDICTED: Bardet-Biedl syndrome 1 protein [Tribolium castaneum]>gi|270013946|gb|EFA10394.1| hypothetical protein TcasGA2_TC012625 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NFJ9 500 5.4e-49 Bardet-Biedl syndrome 1 protein OS=Homo sapiens GN=BBS1 PE=1 SV=1 PF01350 Flavivirus non-structural protein NS4A GO:0016070//GO:0016032 RNA metabolic process//viral process -- -- GO:0019012 virion -- -- Cluster-8309.6958 BF_2 5.00 0.31 964 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01429 Methyl-CpG binding domain -- -- GO:0003677 DNA binding GO:0005634 nucleus -- -- Cluster-8309.6960 BF_2 3.00 0.40 598 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.6967 BF_2 223.00 19.56 764 546681081 ERL91237.1 468 2.7e-44 hypothetical protein D910_08573 [Dendroctonus ponderosae] -- -- -- -- -- K17430 MRPL49, NOF1 large subunit ribosomal protein L49 http://www.genome.jp/dbget-bin/www_bget?ko:K17430 Q9VYI3 311 1.8e-27 Probable 39S ribosomal protein L49, mitochondrial OS=Drosophila melanogaster GN=mRpL49 PE=3 SV=1 PF05046 Mitochondrial large subunit ribosomal protein (Img2) GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG4034 Uncharacterized conserved protein NOF (Neighbor of FAU) Cluster-8309.6991 BF_2 29.00 0.75 1910 297595480 ADI48181.1 1758 1.7e-193 membrane alanyl aminopeptidase 1 [Chrysomela tremula] 734643955 XM_010752691.1 36 8.35454e-07 PREDICTED: Larimichthys crocea aminopeptidase N-like (LOC104936625), mRNA K11140 ANPEP aminopeptidase N http://www.genome.jp/dbget-bin/www_bget?ko:K11140 P15684 918 1.8e-97 Aminopeptidase N OS=Rattus norvegicus GN=Anpep PE=1 SV=2 PF01433 Peptidase family M1 -- -- GO:0008270//GO:0008237 zinc ion binding//metallopeptidase activity -- -- -- -- Cluster-8309.7 BF_2 4.00 5.84 299 299829282 NP_001177722.1 138 1.9e-06 cytochrome P450 CYP6BQ9 [Tribolium castaneum]>gi|296495592|gb|ADH29768.1| cytochrome P450 CYP6BQ9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.70 BF_2 1.00 24.70 212 -- -- -- -- -- 55297352 AP005930.3 199 1.96518e-98 Oryza sativa Japonica Group genomic DNA, chromosome 6, PAC clone:P0502B12 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7006 BF_2 2.00 0.33 537 675389793 KFM82690.1 264 8.5e-21 Tumor protein D54, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- P55326 177 4.3e-12 Uncharacterized protein F13E6.1 OS=Caenorhabditis elegans GN=F13E6.1 PE=3 SV=2 PF07544//PF07464//PF09177//PF03938 RNA polymerase II transcription mediator complex subunit 9//Apolipophorin-III precursor (apoLp-III)//Syntaxin 6, N-terminal//Outer membrane protein (OmpH-like) GO:0006357//GO:0048193//GO:0006869 regulation of transcription from RNA polymerase II promoter//Golgi vesicle transport//lipid transport GO:0051082//GO:0001104//GO:0008289 unfolded protein binding//RNA polymerase II transcription cofactor activity//lipid binding GO:0016020//GO:0005576//GO:0016592 membrane//extracellular region//mediator complex KOG4010 Coiled-coil protein TPD52 Cluster-8309.7011 BF_2 8.00 0.32 1348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7025 BF_2 2.00 1.49 337 83628250 ABC26005.1 199 1.8e-13 arthrodial cuticle protein AMP16.3 [Callinectes sapidus] -- -- -- -- -- -- -- -- -- P81577 193 3.7e-14 Cuticle protein AM1199 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.7026 BF_2 1.00 0.71 340 -- -- -- -- -- 657788198 XM_008322733.1 53 4.85383e-17 PREDICTED: Cynoglossus semilaevis mannosidase, alpha, class 1C, member 1 (man1c1), transcript variant X4, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7028 BF_2 61.24 1.54 1953 642922564 XP_008193228.1 600 3.4e-59 PREDICTED: inhibitor of growth protein 5 isoform X2 [Tribolium castaneum] 170041067 XM_001848247.1 126 7.96243e-57 Culex quinquefasciatus inhibitor of growth protein, ing4, mRNA K11346 ING4 inhibitor of growth protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K11346 Q5ZKY4 378 7.7e-35 Inhibitor of growth protein 4 OS=Gallus gallus GN=ING4 PE=2 SV=1 PF06320//PF00103//PF00628 GCN5-like protein 1 (GCN5L1)//Somatotropin hormone family//PHD-finger GO:0007165 signal transduction GO:0005515//GO:0005179 protein binding//hormone activity GO:0031083//GO:0005576 BLOC-1 complex//extracellular region KOG1973 Chromatin remodeling protein, contains PHD Zn-finger Cluster-8309.7030 BF_2 24.00 2.47 694 328899526 AEB54639.1 757 7.5e-78 ribosomal protein L13 [Procambarus clarkii] 338224469 HM217883.1 165 5.7266e-79 Scylla paramamosain ribosomal protein rpl13 mRNA, partial cds K02873 RP-L13e, RPL13 large subunit ribosomal protein L13e http://www.genome.jp/dbget-bin/www_bget?ko:K02873 Q90YV5 526 1.9e-52 60S ribosomal protein L13 OS=Ictalurus punctatus GN=rpl13 PE=2 SV=3 PF01294 Ribosomal protein L13e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3295 60S Ribosomal protein L13 Cluster-8309.7033 BF_2 36.00 0.32 4977 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7042 BF_2 16.83 0.71 1281 642932264 XP_008197038.1 646 1.0e-64 PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum]>gi|642932266|ref|XP_008197039.1| PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K13349 MPV17L Mpv17-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13349 Q68F62 299 7.3e-26 Mpv17-like protein OS=Xenopus laevis GN=mpv17l PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.7044 BF_2 104.58 5.83 1037 642932264 XP_008197038.1 646 8.3e-65 PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum]>gi|642932266|ref|XP_008197039.1| PREDICTED: mpv17-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- K13349 MPV17L Mpv17-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K13349 Q68F62 299 5.9e-26 Mpv17-like protein OS=Xenopus laevis GN=mpv17l PE=2 SV=1 PF06736//PF04117 Protein of unknown function (DUF1211)//Mpv17 / PMP22 family GO:0006813 potassium ion transport GO:0005267 potassium channel activity GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.7045 BF_2 2.00 0.44 477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7051 BF_2 4.04 0.40 711 642916527 XP_008191079.1 451 2.3e-42 PREDICTED: glutamate receptor ionotropic, kainate 2-like [Tribolium castaneum] -- -- -- -- -- K05205 GRIK5 glutamate receptor, ionotropic kainate 5 http://www.genome.jp/dbget-bin/www_bget?ko:K05205 Q61626 167 8.2e-11 Glutamate receptor ionotropic, kainate 5 OS=Mus musculus GN=Grik5 PE=2 SV=2 PF01155 Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006464 cellular protein modification process GO:0016151 nickel cation binding -- -- -- -- Cluster-8309.7062 BF_2 1.00 0.34 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7071 BF_2 145.29 25.02 530 478259443 ENN79333.1 141 1.5e-06 hypothetical protein YQE_04242, partial [Dendroctonus ponderosae]>gi|546675184|gb|ERL86420.1| hypothetical protein D910_03827 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7076 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7077 BF_2 7.47 0.31 1299 478254288 ENN74542.1 252 5.1e-19 hypothetical protein YQE_08865, partial [Dendroctonus ponderosae]>gi|546679310|gb|ERL89797.1| hypothetical protein D910_07158 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00538 linker histone H1 and H5 family GO:0006334 nucleosome assembly GO:0003677 DNA binding GO:0000786//GO:0005634 nucleosome//nucleus -- -- Cluster-8309.7090 BF_2 16.11 0.47 1710 642923261 XP_008193681.1 877 2.2e-91 PREDICTED: T-cell activation inhibitor, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66JZ4 316 1.0e-27 T-cell activation inhibitor, mitochondrial OS=Mus musculus GN=TCAIM PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7092 BF_2 4.00 0.34 777 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7096 BF_2 19.00 0.34 2635 751463814 XP_011186824.1 1196 3.5e-128 PREDICTED: uncharacterized protein LOC105214855 [Bactrocera cucurbitae] 642940417 XM_008193059.1 212 1.6828e-104 PREDICTED: Tribolium castaneum poliovirus receptor-related protein 3-like (LOC103312443), partial mRNA -- -- -- -- Q9JLB9 175 3.6e-11 Nectin-3 OS=Mus musculus GN=Pvrl3 PE=1 SV=1 PF08086//PF13895 Ergtoxin family//Immunoglobulin domain GO:0006810//GO:0009405 transport//pathogenesis GO:0019870//GO:0005515 potassium channel inhibitor activity//protein binding GO:0005576 extracellular region -- -- Cluster-8309.7098 BF_2 2.00 0.47 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7120 BF_2 27.00 1.14 1282 270006433 EFA02881.1 945 2.2e-99 sloppy-paired 2 [Tribolium castaneum] 584010153 XM_006799949.1 116 1.87514e-51 PREDICTED: Neolamprologus brichardi forkhead box protein G1-like (LOC102798061), mRNA K09385 FOXG forkhead box protein G http://www.genome.jp/dbget-bin/www_bget?ko:K09385 P32031 555 1.5e-55 Fork head domain transcription factor slp2 OS=Drosophila melanogaster GN=slp2 PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-8309.7124 BF_2 10.00 0.81 802 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7133 BF_2 8.00 0.32 1341 478251118 ENN71594.1 1496 2.9e-163 hypothetical protein YQE_11693, partial [Dendroctonus ponderosae]>gi|546680340|gb|ERL90626.1| hypothetical protein D910_07973 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8BQT2 326 5.6e-29 Protein FAM69C OS=Mus musculus GN=Fam69c PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7141 BF_2 3.00 0.42 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7149 BF_2 49.00 1.04 2264 546681949 ERL91945.1 2152 4.3e-239 hypothetical protein D910_09268 [Dendroctonus ponderosae] 462361201 APGK01029141.1 87 4.42882e-35 Dendroctonus ponderosae Seq01029151, whole genome shotgun sequence -- -- -- -- Q50LG9 312 4.0e-27 Leucine-rich repeat-containing protein 24 OS=Homo sapiens GN=LRRC24 PE=2 SV=2 PF13895//PF13855//PF00560 Immunoglobulin domain//Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG4237 Extracellular matrix protein slit, contains leucine-rich and EGF-like repeats Cluster-8309.7150 BF_2 16.00 1.94 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7153 BF_2 28.58 0.69 2021 478253032 ENN73412.1 295 8.1e-24 hypothetical protein YQE_09974, partial [Dendroctonus ponderosae] -- -- -- -- -- K04506 SIAH1 E3 ubiquitin-protein ligase SIAH1 http://www.genome.jp/dbget-bin/www_bget?ko:K04506 Q86MW9 229 1.5e-17 E3 ubiquitin-protein ligase sina OS=Schistosoma mansoni GN=SINA PE=1 SV=1 PF07967//PF02176//PF03145 C3HC zinc finger-like//TRAF-type zinc finger//Seven in absentia protein family GO:0006511//GO:0007275 ubiquitin-dependent protein catabolic process//multicellular organismal development GO:0008270 zinc ion binding GO:0005634 nucleus KOG3002 Zn finger protein Cluster-8309.7155 BF_2 47.20 0.45 4694 642927778 XP_008195402.1 2132 1.8e-236 PREDICTED: uncharacterized protein LOC658369 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04103//PF07690//PF07710 CD20-like family//Major Facilitator Superfamily//P53 tetramerisation motif GO:0051262//GO:0055085 protein tetramerization//transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.7165 BF_2 5.65 0.37 932 91078258 XP_970899.1 337 5.1e-29 PREDICTED: conserved oligomeric Golgi complex subunit 6 [Tribolium castaneum]>gi|270003921|gb|EFA00369.1| hypothetical protein TcasGA2_TC003211 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q3SZI7 236 1.1e-18 Conserved oligomeric Golgi complex subunit 6 OS=Bos taurus GN=COG6 PE=2 SV=1 PF06580 Histidine kinase GO:0000160//GO:0006891//GO:0016310 phosphorelay signal transduction system//intra-Golgi vesicle-mediated transport//phosphorylation GO:0000155 phosphorelay sensor kinase activity GO:0017119//GO:0016021//GO:0009365 Golgi transport complex//integral component of membrane//protein histidine kinase complex KOG3758 Uncharacterized conserved protein Cluster-8309.7170 BF_2 65.02 1.06 2846 546679820 ERL90212.1 1294 1.7e-139 hypothetical protein D910_07566 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9BQA5 823 2.8e-86 Histone H4 transcription factor OS=Homo sapiens GN=HINFP PE=1 SV=2 PF00096//PF13465//PF13912//PF07823 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//Cyclic phosphodiesterase-like protein -- -- GO:0046872//GO:0004112 metal ion binding//cyclic-nucleotide phosphodiesterase activity -- -- -- -- Cluster-8309.7175 BF_2 13.00 0.44 1524 642918597 XP_008197482.1 177 3.0e-10 PREDICTED: pleckstrin homology domain-containing family G member 4B-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7181 BF_2 12.55 0.34 1816 270007714 EFA04162.1 650 5.0e-65 hypothetical protein TcasGA2_TC014408 [Tribolium castaneum] 571544593 XM_006564502.1 92 5.87972e-38 PREDICTED: Apis mellifera GB15078 protein (Gb15078), transcript variant X1, mRNA -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.7190 BF_2 1.64 0.38 468 642913383 XP_969242.3 327 3.7e-28 PREDICTED: valacyclovir hydrolase [Tribolium castaneum]>gi|270001736|gb|EEZ98183.1| hypothetical protein TcasGA2_TC000612 [Tribolium castaneum] -- -- -- -- -- K18399 BPHL valacyclovir hydrolase http://www.genome.jp/dbget-bin/www_bget?ko:K18399 Q8R164 184 5.7e-13 Valacyclovir hydrolase OS=Mus musculus GN=Bphl PE=1 SV=1 PF00326//PF01738 Prolyl oligopeptidase family//Dienelactone hydrolase family GO:0006508 proteolysis GO:0016787//GO:0008236 hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.7205 BF_2 51.33 2.12 1302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7210 BF_2 72.22 4.79 918 642919236 XP_008191788.1 655 6.7e-66 PREDICTED: coiled-coil domain-containing protein 134 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9H6E4 295 1.5e-25 Coiled-coil domain-containing protein 134 OS=Homo sapiens GN=CCDC134 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7229 BF_2 9.00 0.40 1226 607354877 EZA49482.1 274 1.3e-21 hypothetical protein X777_12276 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7232 BF_2 10.00 0.37 1431 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF07503//PF00641 HypF finger//Zn-finger in Ran binding protein and others -- -- GO:0008270 zinc ion binding -- -- -- -- Cluster-8309.7239 BF_2 6.00 0.49 800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7241 BF_2 1.00 2.52 276 220983400 BAH11170.1 322 8.2e-28 preprosulfakinin [Psacothea hilaris hilaris] 220983399 AB477348.1 108 1.02381e-47 Psacothea hilaris hilaris sk mRNA for preprosulfakinin, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7243 BF_2 26.70 1.04 1359 478265967 ENN82639.1 215 1.0e-14 hypothetical protein YQE_00987, partial [Dendroctonus ponderosae]>gi|478265974|gb|ENN82644.1| hypothetical protein YQE_00985, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O46108 152 8.6e-09 Lipase 3 OS=Drosophila melanogaster GN=Lip3 PE=2 SV=1 PF04083 Partial alpha/beta-hydrolase lipase region GO:0006629 lipid metabolic process -- -- -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-8309.7245 BF_2 15.07 0.44 1724 478252288 ENN72715.1 415 8.5e-38 hypothetical protein YQE_10653, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5DU00 162 7.6e-10 Doublecortin domain-containing protein 2 OS=Mus musculus GN=Dcdc2 PE=2 SV=2 PF03607 Doublecortin GO:0035556 intracellular signal transduction -- -- -- -- -- -- Cluster-8309.7247 BF_2 67.00 1.51 2145 478259368 ENN79267.1 1149 8.1e-123 hypothetical protein YQE_04302, partial [Dendroctonus ponderosae]>gi|478267667|gb|ENN83082.1| hypothetical protein YQE_00556, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9VZU2 490 8.7e-48 Protein-cysteine N-palmitoyltransferase Rasp OS=Drosophila melanogaster GN=rasp PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3860 Acyltransferase required for palmitoylation of Hedgehog (Hh) family of secreted signaling proteins Cluster-8309.725 BF_2 2.00 0.67 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7258 BF_2 20.00 0.54 1833 91088471 XP_969928.1 1154 1.8e-123 PREDICTED: lactosylceramide 4-alpha-galactosyltransferase [Tribolium castaneum]>gi|642931778|ref|XP_008196724.1| PREDICTED: lactosylceramide 4-alpha-galactosyltransferase [Tribolium castaneum]>gi|270011737|gb|EFA08185.1| hypothetical protein TcasGA2_TC005812 [Tribolium castaneum] -- -- -- -- -- K01988 A4GALT lactosylceramide 4-alpha-galactosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K01988 Q67BJ4 359 1.2e-32 Lactosylceramide 4-alpha-galactosyltransferase OS=Mus musculus GN=A4galt PE=2 SV=1 PF12919 TcdA/TcdB catalytic glycosyltransferase domain -- -- GO:0016757 transferase activity, transferring glycosyl groups -- -- KOG1928 Alpha-1,4-N-acetylglucosaminyltransferase Cluster-8309.726 BF_2 7.00 0.35 1128 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7261 BF_2 104.00 5.83 1033 642929753 XP_975520.3 565 2.0e-55 PREDICTED: putative gustatory receptor 28b [Tribolium castaneum] -- -- -- -- -- K08471 GR gustatory receptor http://www.genome.jp/dbget-bin/www_bget?ko:K08471 Q9VM08 162 4.5e-10 Putative gustatory receptor 28b OS=Drosophila melanogaster GN=Gr28b PE=1 SV=2 PF08395//PF06151//PF05933 7tm Chemosensory receptor//Trehalose receptor//Fungal ATP synthase protein 8 (A6L) GO:0015992//GO:0050909//GO:0015986//GO:0050912//GO:0007607//GO:0007187 proton transport//sensory perception of taste//ATP synthesis coupled proton transport//detection of chemical stimulus involved in sensory perception of taste//obsolete taste perception//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0008527//GO:0015078 taste receptor activity//hydrogen ion transmembrane transporter activity GO:0000276//GO:0016021 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)//integral component of membrane -- -- Cluster-8309.7267 BF_2 29.00 0.58 2381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7274 BF_2 7.13 0.42 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7276 BF_2 11.00 1.78 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01544//PF00242 CorA-like Mg2+ transporter protein//DNA polymerase (viral) N-terminal domain GO:0006260//GO:0055085//GO:0030001 DNA replication//transmembrane transport//metal ion transport GO:0046873//GO:0003887//GO:0003677 metal ion transmembrane transporter activity//DNA-directed DNA polymerase activity//DNA binding GO:0016020//GO:0042575 membrane//DNA polymerase complex -- -- Cluster-8309.7282 BF_2 1.00 0.53 362 270003289 EEZ99736.1 218 1.2e-15 hypothetical protein TcasGA2_TC002505 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7288 BF_2 44.56 0.49 4059 270010437 EFA06885.1 2442 1.8e-272 hypothetical protein TcasGA2_TC009830 [Tribolium castaneum] 827546919 XM_004926175.2 138 3.56326e-63 PREDICTED: Bombyx mori protein prickle-like (LOC101737057), mRNA K04511 PRICKLE prickle http://www.genome.jp/dbget-bin/www_bget?ko:K04511 A1Z6W3 1451 6.1e-159 Protein prickle OS=Drosophila melanogaster GN=pk PE=1 SV=1 PF01777//PF02529//PF00412//PF06297 Ribosomal L27e protein family//Cytochrome B6-F complex subunit 5//LIM domain//PET Domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0008270//GO:0003735 zinc ion binding//structural constituent of ribosome GO:0009512//GO:0005622//GO:0005840 cytochrome b6f complex//intracellular//ribosome KOG1704 FOG: LIM domain Cluster-8309.7300 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7301 BF_2 2.00 0.72 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7316 BF_2 9.58 0.38 1338 669313562 KFD57019.1 151 2.7e-07 hypothetical protein M513_02276 [Trichuris suis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7326 BF_2 28.19 1.12 1344 189240152 XP_001814944.1 322 4.0e-27 PREDICTED: uncharacterized protein LOC100141720 [Tribolium castaneum]>gi|270012273|gb|EFA08721.1| hypothetical protein TcasGA2_TC006395 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7332 BF_2 25.00 0.77 1643 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7333 BF_2 3.00 0.65 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7334 BF_2 267.19 2.33 5082 672033453 XP_008756456.1 424 2.3e-38 PREDICTED: LOW QUALITY PROTEIN: zinc finger protein 160-like isoform X1, partial [Rattus norvegicus] 642924758 XM_008196206.1 138 4.46935e-63 PREDICTED: Tribolium castaneum PR domain zinc finger protein 1 (LOC100142159), transcript variant X4, mRNA -- -- -- -- Q61116 419 3.5e-39 Zinc finger protein 235 OS=Mus musculus GN=Znf235 PE=2 SV=1 PF13912//PF00856//PF00096//PF13465 C2H2-type zinc finger//SET domain//Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0005515//GO:0046872 protein binding//metal ion binding -- -- -- -- Cluster-8309.7343 BF_2 8.00 0.35 1237 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7349 BF_2 19.76 0.54 1824 91084727 XP_970450.1 1794 1.1e-197 PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|642925824|ref|XP_008190453.1| PREDICTED: uncharacterized protein LOC659018 [Tribolium castaneum]>gi|270008937|gb|EFA05385.1| hypothetical protein TcasGA2_TC015557 [Tribolium castaneum] 242000649 XM_002434923.1 66 1.67735e-23 Ixodes scapularis conserved hypothetical protein, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7351 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7352 BF_2 3.00 0.36 634 541906808 AGV28716.1 586 4.6e-58 timeless [Eurydice pulchra] -- -- -- -- -- -- -- -- -- O17482 334 3.2e-30 Protein timeless OS=Drosophila virilis GN=tim PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7355 BF_2 14.90 0.71 1162 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7365 BF_2 112.84 0.83 6009 642919785 XP_008192065.1 3759 0.0e+00 PREDICTED: kinesin-like protein CG14535 isoform X2 [Tribolium castaneum] 759038090 XM_011353258.1 51 1.22046e-14 PREDICTED: Cerapachys biroi kinesin-like protein CG14535 (LOC105287618), mRNA K10404 KIF26 kinesin family member 26 http://www.genome.jp/dbget-bin/www_bget?ko:K10404 Q7TNC6 924 1.2e-97 Kinesin-like protein KIF26B OS=Mus musculus GN=Kif26b PE=1 SV=3 PF00225 Kinesin motor domain GO:0007018//GO:0007017 microtubule-based movement//microtubule-based process GO:0008017//GO:0005524//GO:0003777 microtubule binding//ATP binding//microtubule motor activity GO:0045298//GO:0005874 tubulin complex//microtubule -- -- Cluster-8309.737 BF_2 3.60 1.44 390 478250337 ENN70834.1 250 2.6e-19 hypothetical protein YQE_12498, partial [Dendroctonus ponderosae]>gi|546680057|gb|ERL90412.1| hypothetical protein D910_07761 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7370 BF_2 4.00 0.35 760 504126452 XP_004576958.1 926 2.1e-97 PREDICTED: elongation factor 1-beta [Ochotona princeps] 158257251 AK291910.1 760 0 Homo sapiens cDNA FLJ75751 complete cds, highly similar to Homo sapiens eukaryotic translation elongation factor 1 beta 2 (EEF1B2), transcript variant 1, mRNA K03232 EEF1B elongation factor 1-beta http://www.genome.jp/dbget-bin/www_bget?ko:K03232 P24534 926 8.5e-99 Elongation factor 1-beta OS=Homo sapiens GN=EEF1B2 PE=1 SV=3 PF00736 EF-1 guanine nucleotide exchange domain GO:0006414//GO:0006448 translational elongation//regulation of translational elongation GO:0003746 translation elongation factor activity GO:0005853//GO:0005840 eukaryotic translation elongation factor 1 complex//ribosome KOG1668 Elongation factor 1 beta/delta chain Cluster-8309.7377 BF_2 5.00 0.63 620 642932244 XP_008197028.1 150 1.6e-07 PREDICTED: allatotropin I preprohormone isoform X1 [Tribolium castaneum]>gi|642932246|ref|XP_008197029.1| PREDICTED: allatotropin I preprohormone isoform X1 [Tribolium castaneum]>gi|642932248|ref|XP_008197030.1| PREDICTED: allatotropin I preprohormone isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03661 Uncharacterised protein family (UPF0121) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.7379 BF_2 2.00 0.48 463 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7384 BF_2 2.00 0.32 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00489 Interleukin-6/G-CSF/MGF family GO:0006955//GO:0040007//GO:0007165//GO:0008283 immune response//growth//signal transduction//cell proliferation GO:0005138 interleukin-6 receptor binding GO:0005896//GO:0005576 interleukin-6 receptor complex//extracellular region -- -- Cluster-8309.739 BF_2 9.00 1.26 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05436 Mating factor alpha precursor N-terminus GO:0007618 mating -- -- GO:0005576 extracellular region -- -- Cluster-8309.7391 BF_2 90.00 1.78 2402 91081779 XP_973526.1 2481 3.2e-277 PREDICTED: ATP-binding cassette sub-family G member 1 [Tribolium castaneum]>gi|270005045|gb|EFA01493.1| hypothetical protein TcasGA2_TC007047 [Tribolium castaneum] -- -- -- -- -- K05679 ABCG1 ATP-binding cassette, subfamily G (WHITE), member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05679 Q64343 1271 2.7e-138 ATP-binding cassette sub-family G member 1 OS=Mus musculus GN=Abcg1 PE=1 SV=1 PF01061//PF13304//PF00005//PF03193//PF00004 ABC-2 type transporter//AAA domain, putative AbiEii toxin, Type IV TA system//ABC transporter//Protein of unknown function, DUF258//ATPase family associated with various cellular activities (AAA) GO:0006200 obsolete ATP catabolic process GO:0005525//GO:0005524//GO:0016887//GO:0003924 GTP binding//ATP binding//ATPase activity//GTPase activity GO:0016021//GO:0016020 integral component of membrane//membrane -- -- Cluster-8309.7393 BF_2 6.00 2.08 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7398 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.740 BF_2 2.12 0.56 445 91094511 XP_971832.1 326 4.6e-28 PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|642937845|ref|XP_008200324.1| PREDICTED: heterogeneous nuclear ribonucleoprotein H [Tribolium castaneum]>gi|270000730|gb|EEZ97177.1| hypothetical protein TcasGA2_TC004364 [Tribolium castaneum] -- -- -- -- -- K12898 HNRNPF_H heterogeneous nuclear ribonucleoprotein F/H http://www.genome.jp/dbget-bin/www_bget?ko:K12898 Q8VHV7 259 1.1e-21 Heterogeneous nuclear ribonucleoprotein H OS=Rattus norvegicus GN=Hnrnph1 PE=1 SV=2 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0000166//GO:0003676 nucleotide binding//nucleic acid binding -- -- KOG4211 Splicing factor hnRNP-F and related RNA-binding proteins Cluster-8309.7401 BF_2 4.00 0.74 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06464 DMAP1-binding Domain -- -- GO:0008134 transcription factor binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.7404 BF_2 2.00 0.42 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7408 BF_2 9.25 0.35 1408 478253705 ENN74004.1 354 8.2e-31 hypothetical protein YQE_09394, partial [Dendroctonus ponderosae]>gi|546678194|gb|ERL88884.1| hypothetical protein D910_06266 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- O97398 257 6.0e-21 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7413 BF_2 5.85 0.97 539 91092284 XP_968475.1 461 1.2e-43 PREDICTED: 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha [Tribolium castaneum]>gi|270001209|gb|EEZ97656.1| hypothetical protein TcasGA2_TC016200 [Tribolium castaneum] -- -- -- -- -- K13509 AGPAT1_2 lysophosphatidate acyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K13509 Q95JH2 158 6.9e-10 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha OS=Bos taurus GN=AGPAT1 PE=2 SV=1 PF01553 Acyltransferase GO:0008152//GO:0008654//GO:0046486//GO:0042967 metabolic process//phospholipid biosynthetic process//glycerolipid metabolic process//acyl-carrier-protein biosynthetic process GO:0003841//GO:0016746 1-acylglycerol-3-phosphate O-acyltransferase activity//transferase activity, transferring acyl groups GO:0016020 membrane -- -- Cluster-8309.7425 BF_2 41.47 0.51 3697 270005515 EFA01963.1 2182 2.3e-242 hypothetical protein TcasGA2_TC007584 [Tribolium castaneum] -- -- -- -- -- K05096 FLT1, VEGFR1 FMS-like tyrosine kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05096 P35969 975 8.7e-104 Vascular endothelial growth factor receptor 1 OS=Mus musculus GN=Flt1 PE=1 SV=1 PF13895//PF02480//PF07714//PF00069//PF02402 Immunoglobulin domain//Alphaherpesvirus glycoprotein E//Protein tyrosine kinase//Protein kinase domain//Lysis protein GO:0006468//GO:0019835//GO:0009405 protein phosphorylation//cytolysis//pathogenesis GO:0004672//GO:0005515//GO:0005524 protein kinase activity//protein binding//ATP binding GO:0016020//GO:0019867 membrane//outer membrane KOG0200 Fibroblast/platelet-derived growth factor receptor and related receptor tyrosine kinases Cluster-8309.7427 BF_2 27.03 0.64 2058 91088619 XP_974054.1 1243 9.8e-134 PREDICTED: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial [Tribolium castaneum]>gi|270011691|gb|EFA08139.1| hypothetical protein TcasGA2_TC005756 [Tribolium castaneum] -- -- -- -- -- K00995 pgsA, PGS1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00995 Q32NB8 632 2.9e-64 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial OS=Homo sapiens GN=PGS1 PE=2 SV=1 PF00614 Phospholipase D Active site motif GO:0008654 phospholipid biosynthetic process GO:0003824//GO:0016780 catalytic activity//phosphotransferase activity, for other substituted phosphate groups -- -- KOG3964 Phosphatidylglycerolphosphate synthase Cluster-8309.7428 BF_2 4.00 0.38 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7433 BF_2 2.00 0.44 478 270016799 EFA13245.1 152 7.3e-08 hypothetical protein TcasGA2_TC001515 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7435 BF_2 26.00 0.53 2339 765147862 XP_011484596.1 765 3.0e-78 PREDICTED: zinc finger protein 883-like [Oryzias latipes] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 702 2.5e-72 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF07776//PF16622//PF13912//PF13465//PF00096 Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//Zinc-finger double domain//Zinc finger, C2H2 type -- -- GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.7437 BF_2 3.00 0.43 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7449 BF_2 8.00 0.52 934 308450159 XP_003088200.1 423 5.4e-39 hypothetical protein CRE_03576 [Caenorhabditis remanei]>gi|308248801|gb|EFO92753.1| hypothetical protein CRE_03576 [Caenorhabditis remanei] 470484592 NR_076656.1 607 0 Flavobacteriaceae bacterium 3519-10 strain 3519-10 23S ribosomal RNA, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7450 BF_2 68.90 1.83 1864 625273553 XP_007628351.1 527 9.4e-51 PREDICTED: zinc finger protein 883-like isoform X5 [Cricetulus griseus] -- -- -- -- -- -- -- -- -- Q5XIU2 811 4.5e-85 Zinc finger protein 143 OS=Rattus norvegicus GN=Znf143 PE=2 SV=2 PF13465//PF00096//PF13912 Zinc-finger double domain//Zinc finger, C2H2 type//C2H2-type zinc finger -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.7465 BF_2 10.51 0.44 1277 642936321 XP_008198395.1 413 1.1e-37 PREDICTED: equilibrative nucleoside transporter 3-like isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q99808 203 9.9e-15 Equilibrative nucleoside transporter 1 OS=Homo sapiens GN=SLC29A1 PE=1 SV=3 PF01733//PF11045//PF00499//PF15461//PF01080 Nucleoside transporter//Putative inner membrane protein of Enterobacteriaceae//NADH-ubiquinone/plastoquinone oxidoreductase chain 6//Beta-carotene 15,15'-dioxygenase//Presenilin GO:0006810//GO:0006120//GO:0015858//GO:0015992//GO:0055114//GO:0006814//GO:0006744 transport//mitochondrial electron transport, NADH to ubiquinone//nucleoside transport//proton transport//oxidation-reduction process//sodium ion transport//ubiquinone biosynthetic process GO:0016702//GO:0004190//GO:0005337//GO:0008137 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen//aspartic-type endopeptidase activity//nucleoside transmembrane transporter activity//NADH dehydrogenase (ubiquinone) activity GO:0016021 integral component of membrane -- -- Cluster-8309.7468 BF_2 5.00 0.34 900 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7477 BF_2 38.00 0.57 3066 546680335 ERL90621.1 1358 6.8e-147 hypothetical protein D910_07968 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q54B37 280 2.8e-23 RhoGEF domain-containing protein gxcJ OS=Dictyostelium discoideum GN=gxcJ PE=3 SV=1 PF00621 RhoGEF domain GO:0043087//GO:0035023 regulation of GTPase activity//regulation of Rho protein signal transduction GO:0005089 Rho guanyl-nucleotide exchange factor activity -- -- KOG4424 Predicted Rho/Rac guanine nucleotide exchange factor/faciogenital dysplasia protein 3 Cluster-8309.7479 BF_2 5.00 0.58 645 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7482 BF_2 7.00 0.52 847 646702911 KDR11879.1 769 3.7e-79 putative NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial [Zootermopsis nevadensis] -- -- -- -- -- K03943 NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03943 Q0MQI9 728 8.6e-76 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial OS=Pan troglodytes GN=NDUFV2 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3196 NADH:ubiquinone oxidoreductase, NDUFV2/24 kD subunit Cluster-8309.7486 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7488 BF_2 46.49 2.30 1133 478259751 ENN79592.1 1082 2.5e-115 hypothetical protein YQE_03963, partial [Dendroctonus ponderosae]>gi|546678748|gb|ERL89300.1| hypothetical protein D910_06672 [Dendroctonus ponderosae] -- -- -- -- -- K14302 NUP37 nuclear pore complex protein Nup37 http://www.genome.jp/dbget-bin/www_bget?ko:K14302 Q9CWU9 431 3.2e-41 Nucleoporin Nup37 OS=Mus musculus GN=Nup37 PE=2 SV=2 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.7490 BF_2 43.00 2.87 914 270010333 EFA06781.1 579 4.3e-57 hypothetical protein TcasGA2_TC009717, partial [Tribolium castaneum] -- -- -- -- -- K12599 SKI2, SKIV2L antiviral helicase SKI2 http://www.genome.jp/dbget-bin/www_bget?ko:K12599 Q15477 220 7.5e-17 Helicase SKI2W OS=Homo sapiens GN=SKIV2L PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7491 BF_2 40.24 1.08 1849 641681639 XP_008189542.1 961 4.4e-101 PREDICTED: uncharacterized protein LOC103311641 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0003677//GO:0016788//GO:0004803 DNA binding//hydrolase activity, acting on ester bonds//transposase activity -- -- -- -- Cluster-8309.7495 BF_2 5.00 2.42 371 195026146 XP_001986192.1 201 1.2e-13 GH21223 [Drosophila grimshawi]>gi|193902192|gb|EDW01059.1| GH21223 [Drosophila grimshawi] 262401214 FJ774789.1 182 1.0403e-88 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7508 BF_2 10.42 0.34 1587 189236600 XP_001816436.1 1644 2.4e-180 PREDICTED: sensory neuron membrane protein 1 [Tribolium castaneum]>gi|332321724|sp|D2A0H5.1|SNMP1_TRICA RecName: Full=Sensory neuron membrane protein 1 [Tribolium castaneum]>gi|270006451|gb|EFA02899.1| sensory neuron membrane protein 1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2A0H5 1644 9.9e-182 Sensory neuron membrane protein 1 OS=Tribolium castaneum GN=SNMP01 PE=3 SV=1 PF01130 CD36 family GO:0007155//GO:0044699 cell adhesion//single-organism process -- -- GO:0016020 membrane -- -- Cluster-8309.7518 BF_2 2.00 3.57 290 91081927 XP_966456.1 148 1.3e-07 PREDICTED: probable glutamate--tRNA ligase, mitochondrial [Tribolium castaneum]>gi|270007328|gb|EFA03776.1| hypothetical protein TcasGA2_TC013887 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- GO:0044260//GO:0044238 cellular macromolecule metabolic process//primary metabolic process GO:0016874 ligase activity -- -- -- -- Cluster-8309.7519 BF_2 2.00 0.53 445 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.754 BF_2 6.00 0.45 841 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7549 BF_2 3.00 2.98 319 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.755 BF_2 5.00 0.96 506 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7552 BF_2 19.61 0.38 2459 827545651 XP_012545324.1 596 1.2e-58 PREDICTED: connectin-like [Bombyx mori] -- -- -- -- -- -- -- -- -- Q01819 529 3.0e-52 Connectin OS=Drosophila melanogaster GN=Con PE=2 SV=2 PF13855//PF00560//PF00664 Leucine rich repeat//Leucine Rich Repeat//ABC transporter transmembrane region GO:0055085//GO:0006810 transmembrane transport//transport GO:0005524//GO:0005515//GO:0042626 ATP binding//protein binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG0619 FOG: Leucine rich repeat Cluster-8309.7557 BF_2 86.00 2.71 1614 546675817 ERL86930.1 1485 6.7e-162 hypothetical protein D910_04333 [Dendroctonus ponderosae] -- -- -- -- -- K13118 DGCR14 protein DGCR14 http://www.genome.jp/dbget-bin/www_bget?ko:K13118 O44424 839 2.2e-88 Protein DGCR14 homolog OS=Drosophila melanogaster GN=Es2 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG2627 Nuclear protein ES2 Cluster-8309.756 BF_2 10.74 0.48 1214 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7569 BF_2 12.20 0.77 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01097 Arthropod defensin GO:0006952 defense response -- -- -- -- -- -- Cluster-8309.7570 BF_2 11.80 1.78 564 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04147//PF04006//PF02724//PF01097 Nop14-like family//Mpp10 protein//CDC45-like protein//Arthropod defensin GO:0006364//GO:0006952//GO:0006270 rRNA processing//defense response//DNA replication initiation -- -- GO:0005732//GO:0005634//GO:0034457//GO:0032040 small nucleolar ribonucleoprotein complex//nucleus//Mpp10 complex//small-subunit processome -- -- Cluster-8309.7574 BF_2 29.03 0.84 1737 270005448 EFA01896.1 1178 2.9e-126 hypothetical protein TcasGA2_TC007506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q42524 828 4.5e-87 4-coumarate--CoA ligase 1 OS=Arabidopsis thaliana GN=4CL1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.7575 BF_2 6.69 0.36 1069 641648626 XP_008182912.1 590 2.7e-58 PREDICTED: putative nuclease HARBI1 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- Q6AZB8 236 1.2e-18 Putative nuclease HARBI1 OS=Danio rerio GN=harbi1 PE=2 SV=1 PF04827//PF01609 Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0016788//GO:0003677//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//transposase activity -- -- -- -- Cluster-8309.7579 BF_2 2.00 0.76 396 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7586 BF_2 18.49 1.44 825 478254358 ENN74610.1 161 1.1e-08 hypothetical protein YQE_08731, partial [Dendroctonus ponderosae]>gi|546677883|gb|ERL88633.1| hypothetical protein D910_06018 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7587 BF_2 177.51 22.65 615 91082323 XP_974575.1 202 1.5e-13 PREDICTED: epididymal secretory protein E1 [Tribolium castaneum]>gi|270008208|gb|EFA04656.1| hypothetical protein TcasGA2_TC014068 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7590 BF_2 27.71 1.01 1440 642920799 XP_008192566.1 727 4.7e-74 PREDICTED: caltractin isoform X1 [Tribolium castaneum] 2920834 U92973.1 100 1.65651e-42 MVU92973 Marsilea vestita centrin (MvCen1) mRNA, complete cds K10840 CETN2 centrin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10840 Q32LE3 659 1.5e-67 Centrin-1 OS=Bos taurus GN=CETN1 PE=2 SV=1 PF13202//PF00036//PF12763//PF00298//PF13499//PF10591//PF13833//PF13405 EF hand//EF hand//Cytoskeletal-regulatory complex EF hand//Ribosomal protein L11, RNA binding domain//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0006412//GO:0007165//GO:0042254 translation//signal transduction//ribosome biogenesis GO:0005515//GO:0003735//GO:0005509 protein binding//structural constituent of ribosome//calcium ion binding GO:0005840//GO:0005578 ribosome//proteinaceous extracellular matrix KOG0028 Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein Cluster-8309.7591 BF_2 45.29 1.44 1600 642920799 XP_008192566.1 727 5.2e-74 PREDICTED: caltractin isoform X1 [Tribolium castaneum] 2920834 U92973.1 100 1.84515e-42 MVU92973 Marsilea vestita centrin (MvCen1) mRNA, complete cds K10840 CETN2 centrin-2 http://www.genome.jp/dbget-bin/www_bget?ko:K10840 Q32LE3 659 1.6e-67 Centrin-1 OS=Bos taurus GN=CETN1 PE=2 SV=1 PF13202//PF00036//PF00298//PF12763//PF13499//PF10591//PF13833//PF13405 EF hand//EF hand//Ribosomal protein L11, RNA binding domain//Cytoskeletal-regulatory complex EF hand//EF-hand domain pair//Secreted protein acidic and rich in cysteine Ca binding region//EF-hand domain pair//EF-hand domain GO:0006412//GO:0007165//GO:0042254 translation//signal transduction//ribosome biogenesis GO:0005515//GO:0005509//GO:0003735 protein binding//calcium ion binding//structural constituent of ribosome GO:0005578//GO:0005840 proteinaceous extracellular matrix//ribosome KOG0028 Ca2+-binding protein (centrin/caltractin), EF-Hand superfamily protein Cluster-8309.7592 BF_2 17.67 0.38 2249 91075996 XP_970892.1 1021 5.9e-108 PREDICTED: probable protein-cysteine N-palmitoyltransferase porcupine [Tribolium castaneum]>gi|270014667|gb|EFA11115.1| hypothetical protein TcasGA2_TC004714 [Tribolium castaneum] -- -- -- -- -- K00181 PPN porcupine http://www.genome.jp/dbget-bin/www_bget?ko:K00181 Q7Q3N5 528 3.6e-52 Protein-serine O-palmitoleoyltransferase porcupine OS=Anopheles gambiae GN=por PE=3 SV=1 PF06422 CDR ABC transporter GO:0006810 transport GO:0005524//GO:0042626 ATP binding//ATPase activity, coupled to transmembrane movement of substances GO:0016021 integral component of membrane KOG4312 Predicted acyltransferase Cluster-8309.7593 BF_2 61.22 1.50 1997 91075996 XP_970892.1 1229 4.0e-132 PREDICTED: probable protein-cysteine N-palmitoyltransferase porcupine [Tribolium castaneum]>gi|270014667|gb|EFA11115.1| hypothetical protein TcasGA2_TC004714 [Tribolium castaneum] -- -- -- -- -- K00181 PPN porcupine http://www.genome.jp/dbget-bin/www_bget?ko:K00181 Q7Q3N5 557 1.4e-55 Protein-serine O-palmitoleoyltransferase porcupine OS=Anopheles gambiae GN=por PE=3 SV=1 -- -- -- -- -- -- -- -- KOG4312 Predicted acyltransferase Cluster-8309.7596 BF_2 15.00 0.44 1712 270013343 EFA09791.1 1418 4.2e-154 hypothetical protein TcasGA2_TC011933 [Tribolium castaneum] 642935264 XM_008199717.1 177 3.10446e-85 PREDICTED: Tribolium castaneum rho GTPase-activating protein 100F (LOC660562), mRNA -- -- -- -- Q9V9S7 906 4.0e-96 Rho GTPase-activating protein 100F OS=Drosophila melanogaster GN=RhoGAP100F PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.7598 BF_2 8.00 0.42 1088 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7600 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7604 BF_2 124.00 3.43 1799 642929057 XP_008195673.1 1028 7.3e-109 PREDICTED: dimethyladenosine transferase 2, mitochondrial [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VH38 413 6.2e-39 Dimethyladenosine transferase 2, mitochondrial OS=Drosophila melanogaster GN=mtTFB2 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7607 BF_2 54.00 1.19 2184 641647727 XP_008179395.1 882 7.5e-92 PREDICTED: jerky protein homolog-like [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03172//PF03184 Sp100 domain//DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding GO:0005634 nucleus -- -- Cluster-8309.7610 BF_2 1.00 0.70 341 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7617 BF_2 11.00 0.52 1164 -- -- -- -- -- 462339182 APGK01036910.1 43 6.46155e-11 Dendroctonus ponderosae Seq01036920, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7625 BF_2 1.00 0.63 349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7627 BF_2 14.00 0.90 938 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.763 BF_2 44.11 0.56 3596 642911951 XP_008199035.1 2062 1.8e-228 PREDICTED: GPI ethanolamine phosphate transferase 1 isoform X1 [Tribolium castaneum] 815881985 XM_001241521.2 35 5.70337e-06 Coccidioides immitis RS GPI ethanolamine phosphate transferase 1 mRNA K05285 PIGN phosphatidylinositol glycan, class N http://www.genome.jp/dbget-bin/www_bget?ko:K05285 Q9R1S3 1386 1.8e-151 GPI ethanolamine phosphate transferase 1 OS=Mus musculus GN=Pign PE=2 SV=2 PF02563//PF04987//PF01676//PF00884//PF01663 Polysaccharide biosynthesis/export protein//Phosphatidylinositolglycan class N (PIG-N)//Metalloenzyme superfamily//Sulfatase//Type I phosphodiesterase / nucleotide pyrophosphatase GO:0006506//GO:0008152//GO:0015774 GPI anchor biosynthetic process//metabolic process//polysaccharide transport GO:0008484//GO:0046872//GO:0003824//GO:0016740//GO:0015159 sulfuric ester hydrolase activity//metal ion binding//catalytic activity//transferase activity//polysaccharide transmembrane transporter activity GO:0016020//GO:0005789 membrane//endoplasmic reticulum membrane KOG2124 Glycosylphosphatidylinositol anchor synthesis protein Cluster-8309.7635 BF_2 2.00 10.25 252 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7636 BF_2 7.00 1.49 483 357607249 EHJ65404.1 312 2.1e-26 hypothetical protein KGM_05439 [Danaus plexippus] -- -- -- -- -- K00418 QCR8, UQCRQ ubiquinol-cytochrome c reductase subunit 8 http://www.genome.jp/dbget-bin/www_bget?ko:K00418 Q9CQ69 238 3.3e-19 Cytochrome b-c1 complex subunit 8 OS=Mus musculus GN=Uqcrq PE=1 SV=3 PF02939 UcrQ family GO:0006118//GO:0015992//GO:0006119 obsolete electron transport//proton transport//oxidative phosphorylation GO:0008121 ubiquinol-cytochrome-c reductase activity -- -- KOG4116 Ubiquinol cytochrome c reductase, subunit QCR8 Cluster-8309.7648 BF_2 4.86 0.33 905 91078340 XP_973522.1 957 6.3e-101 PREDICTED: palmitoyltransferase ZDHHC3 [Tribolium castaneum]>gi|270003971|gb|EFA00419.1| hypothetical protein TcasGA2_TC003270 [Tribolium castaneum] 826428140 XM_012672310.1 144 3.56621e-67 PREDICTED: Monomorium pharaonis palmitoyltransferase ZDHHC3 (LOC105831873), mRNA K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q8R173 668 8.4e-69 Palmitoyltransferase ZDHHC3 OS=Mus musculus GN=Zdhhc3 PE=1 SV=1 PF00219//PF01529 Insulin-like growth factor binding protein//DHHC palmitoyltransferase GO:0001558 regulation of cell growth GO:0046872//GO:0008270//GO:0005520 metal ion binding//zinc ion binding//insulin-like growth factor binding GO:0016942//GO:0005576 insulin-like growth factor binding protein complex//extracellular region KOG1315 Predicted DHHC-type Zn-finger protein Cluster-8309.7649 BF_2 1.00 0.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7657 BF_2 4.00 1.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7659 BF_2 68.51 0.40 7450 591350379 XP_007069726.1 598 2.2e-58 PREDICTED: zinc finger protein 850-like [Chelonia mydas] 642917654 XM_008195282.1 379 0 PREDICTED: Tribolium castaneum zinc finger protein 502 (LOC100141877), mRNA -- -- -- -- P28698 556 6.7e-55 Myeloid zinc finger 1 OS=Homo sapiens GN=MZF1 PE=1 SV=3 PF13912//PF01429//PF16622//PF06350//PF00096//PF13465//PF01155 C2H2-type zinc finger//Methyl-CpG binding domain//zinc-finger C2H2-type//Hormone-sensitive lipase (HSL) N-terminus//Zinc finger, C2H2 type//Zinc-finger double domain//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0008203//GO:0006464//GO:0016042 cholesterol metabolic process//cellular protein modification process//lipid catabolic process GO:0016151//GO:0003677//GO:0046872//GO:0016298 nickel cation binding//DNA binding//metal ion binding//lipase activity GO:0005634 nucleus -- -- Cluster-8309.7661 BF_2 93.00 3.20 1502 332375432 AEE62857.1 1336 1.2e-144 unknown [Dendroctonus ponderosae]>gi|546681108|gb|ERL91264.1| hypothetical protein D910_08598 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5BLY5 625 1.4e-63 Venom acid phosphatase Acph-1 OS=Apis mellifera PE=1 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0006771//GO:0019497 riboflavin metabolic process//hexachlorocyclohexane metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.7664 BF_2 9.91 0.92 740 332376491 AEE63385.1 519 3.2e-50 unknown [Dendroctonus ponderosae]>gi|546680485|gb|ERL90751.1| hypothetical protein D910_08098 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- A7RUD5 457 2.0e-44 Cytosolic Fe-S cluster assembly factor NUBP1 homolog OS=Nematostella vectensis GN=v1g236650 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3022 Predicted ATPase, nucleotide-binding Cluster-8309.7670 BF_2 1.00 0.80 332 225711690 ACO11691.1 278 1.2e-22 ORF91 [Caligus rogercresseyi] 662020131 NR_122018.1 273 2.38392e-139 Sphingomonas sanxanigenens strain NX02 23S ribosomal RNA gene, complete sequence -- -- -- -- Q3BAI2 193 3.7e-14 Uncharacterized protein ORF91 OS=Phalaenopsis aphrodite subsp. formosana PE=4 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7673 BF_2 4.69 0.50 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7676 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7681 BF_2 44.00 2.70 969 635015808 XP_008007775.1 1058 1.3e-112 PREDICTED: LOW QUALITY PROTEIN: ferritin heavy chain [Chlorocebus sabaeus] 56682958 NM_002032.2 942 0 Homo sapiens ferritin, heavy polypeptide 1 (FTH1), mRNA K00522 FTH1 ferritin heavy chain http://www.genome.jp/dbget-bin/www_bget?ko:K00522 P02794 968 1.5e-103 Ferritin heavy chain OS=Homo sapiens GN=FTH1 PE=1 SV=2 PF02915//PF10399//PF00210//PF02387 Rubrerythrin//Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal//Ferritin-like domain//IncFII RepA protein family GO:0006879//GO:0006276//GO:0006119//GO:0006118//GO:0055114//GO:0015992 cellular iron ion homeostasis//plasmid maintenance//oxidative phosphorylation//obsolete electron transport//oxidation-reduction process//proton transport GO:0008121//GO:0016491//GO:0008199//GO:0046872 ubiquinol-cytochrome-c reductase activity//oxidoreductase activity//ferric iron binding//metal ion binding -- -- -- -- Cluster-8309.7687 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.769 BF_2 3.90 0.39 704 546682476 ERL92399.1 287 2.4e-23 hypothetical protein D910_09713 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7691 BF_2 5.00 0.38 835 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7692 BF_2 4.00 0.42 683 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.770 BF_2 2.00 0.56 437 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7717 BF_2 6.81 0.43 943 642927913 XP_008195445.1 591 1.8e-58 PREDICTED: tRNA selenocysteine 1-associated protein 1 isoform X1 [Tribolium castaneum]>gi|270010282|gb|EFA06730.1| hypothetical protein TcasGA2_TC009661 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9NX07 291 4.5e-25 tRNA selenocysteine 1-associated protein 1 OS=Homo sapiens GN=TRNAU1AP PE=1 SV=1 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676//GO:0000166 nucleic acid binding//nucleotide binding -- -- KOG0118 FOG: RRM domain Cluster-8309.7723 BF_2 2.08 0.78 398 478256092 ENN76291.1 150 1.0e-07 hypothetical protein YQE_07254, partial [Dendroctonus ponderosae]>gi|546675832|gb|ERL86937.1| hypothetical protein D910_04339 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7730 BF_2 2.00 0.87 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7739 BF_2 2.00 0.64 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7767 BF_2 1.00 1.78 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7769 BF_2 2.00 6.65 266 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7771 BF_2 1.00 3.05 269 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7772 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7774 BF_2 74.39 1.44 2455 642911640 XP_008200682.1 1107 6.9e-118 PREDICTED: protein RRNAD1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5E9V4 471 1.6e-45 Protein RRNAD1 OS=Bos taurus GN=RRNAD1 PE=2 SV=1 PF08123 Histone methylation protein DOT1 GO:0006554//GO:0006479 lysine catabolic process//protein methylation GO:0018024 histone-lysine N-methyltransferase activity -- -- KOG2651 rRNA adenine N-6-methyltransferase Cluster-8309.7778 BF_2 1.00 0.32 416 246372819 ABL10360.2 615 1.3e-61 voltage-gated sodium channel [Cancer borealis] 246372818 EF089568.2 308 1.06764e-158 Cancer borealis voltage-gated sodium channel mRNA, complete cds K05388 SCNAN voltage-gated sodium channel alpha, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05388 P35500 526 1.1e-52 Sodium channel protein para OS=Drosophila melanogaster GN=para PE=2 SV=3 PF06112//PF00520//PF02066 Gammaherpesvirus capsid protein//Ion transport protein//Metallothionein family 11 GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216//GO:0005507 ion channel activity//copper ion binding GO:0019028//GO:0016020 viral capsid//membrane -- -- Cluster-8309.7785 BF_2 40.00 1.32 1559 478258633 ENN78683.1 790 2.5e-81 hypothetical protein YQE_04855, partial [Dendroctonus ponderosae]>gi|546685789|gb|ERL95238.1| hypothetical protein D910_12505 [Dendroctonus ponderosae] 887513394 KP641320.1 182 4.68763e-88 Leptinotarsa decemlineata putative twist mRNA, complete cds K09069 TWIST twist http://www.genome.jp/dbget-bin/www_bget?ko:K09069 Q8WVJ9 394 8.6e-37 Twist-related protein 2 OS=Homo sapiens GN=TWIST2 PE=1 SV=1 PF00010//PF04947 Helix-loop-helix DNA-binding domain//Poxvirus Late Transcription Factor VLTF3 like GO:0046782 regulation of viral transcription GO:0046983 protein dimerization activity -- -- KOG4447 Transcription factor TWIST Cluster-8309.7794 BF_2 4.00 0.42 687 270016869 EFA13315.1 579 3.2e-57 hypothetical protein TcasGA2_TC008558 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P16425 247 4.2e-20 Putative 115 kDa protein in type-1 retrotransposable element R1DM OS=Drosophila melanogaster GN=R1A1-element\ORF2 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7803 BF_2 3.00 0.48 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7813 BF_2 11.00 1.06 723 255653874 ACU25385.1 212 1.2e-14 crustin 4 [Panulirus japonicus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00095 WAP-type (Whey Acidic Protein) 'four-disulfide core' -- -- GO:0030414 peptidase inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.7815 BF_2 1.54 0.76 369 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.782 BF_2 21.00 0.72 1507 545889810 XP_005658365.1 513 3.2e-49 PREDICTED: zinc finger protein 33B-like, partial [Sus scrofa] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q06732 497 9.4e-49 Zinc finger protein 33B OS=Homo sapiens GN=ZNF33B PE=1 SV=2 PF13465//PF00096//PF07776//PF16622//PF13912//PF02892 Zinc-finger double domain//Zinc finger, C2H2 type//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger//BED zinc finger -- -- GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.7822 BF_2 5.00 0.80 548 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7825 BF_2 10.00 0.37 1403 62087534 BAD92214.1 1693 4.4e-186 ribosomal protein L4 variant [Homo sapiens] 332205903 NM_000968.3 1403 0 Homo sapiens ribosomal protein L4 (RPL4), mRNA K02930 RP-L4e, RPL4 large subunit ribosomal protein L4e http://www.genome.jp/dbget-bin/www_bget?ko:K02930 P36578 1634 1.3e-180 60S ribosomal protein L4 OS=Homo sapiens GN=RPL4 PE=1 SV=5 PF00573//PF01165 Ribosomal protein L4/L1 family//Ribosomal protein S21 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1475 Ribosomal protein RPL1/RPL2/RL4L4 Cluster-8309.7826 BF_2 20.03 0.75 1409 484759898 YP_007890507.1 865 4.6e-90 cytochrome c oxidase subunit II (mitochondrion) [Andalucia godoyi]>gi|462269129|gb|AGH24001.1| cytochrome c oxidase subunit 2 (mitochondrion) [Andalucia godoyi] 119710194 DQ490951.2 838 0 Zea mays subsp. mays genotype CMS-S mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P00412 1246 1.2e-135 Cytochrome c oxidase subunit 2 OS=Zea mays GN=COX2 PE=2 SV=4 PF01529//PF00116//PF02790 DHHC palmitoyltransferase//Cytochrome C oxidase subunit II, periplasmic domain//Cytochrome C oxidase subunit II, transmembrane domain GO:0006123//GO:0015992//GO:0022900 mitochondrial electron transport, cytochrome c to oxygen//proton transport//electron transport chain GO:0005507//GO:0004129//GO:0008270 copper ion binding//cytochrome-c oxidase activity//zinc ion binding GO:0045277//GO:0016021//GO:0016020 respiratory chain complex IV//integral component of membrane//membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.7827 BF_2 57.97 2.12 1433 484759898 YP_007890507.1 865 4.6e-90 cytochrome c oxidase subunit II (mitochondrion) [Andalucia godoyi]>gi|462269129|gb|AGH24001.1| cytochrome c oxidase subunit 2 (mitochondrion) [Andalucia godoyi] 114309646 DQ984518.1 822 0 Sorghum bicolor mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P00412 1246 1.3e-135 Cytochrome c oxidase subunit 2 OS=Zea mays GN=COX2 PE=2 SV=4 PF02790//PF01529//PF00116 Cytochrome C oxidase subunit II, transmembrane domain//DHHC palmitoyltransferase//Cytochrome C oxidase subunit II, periplasmic domain GO:0006123//GO:0022900//GO:0015992 mitochondrial electron transport, cytochrome c to oxygen//electron transport chain//proton transport GO:0005507//GO:0008270//GO:0004129 copper ion binding//zinc ion binding//cytochrome-c oxidase activity GO:0016021//GO:0045277//GO:0016020 integral component of membrane//respiratory chain complex IV//membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.7829 BF_2 130.00 8.75 909 642939786 XP_008193657.1 481 9.9e-46 PREDICTED: COMM domain-containing protein 5 [Tribolium castaneum]>gi|642939788|ref|XP_008193664.1| PREDICTED: COMM domain-containing protein 5 [Tribolium castaneum]>gi|270015429|gb|EFA11877.1| hypothetical protein TcasGA2_TC004291 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8R395 141 1.1e-07 COMM domain-containing protein 5 OS=Mus musculus GN=Commd5 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.7834 BF_2 5.82 0.65 664 546681102 ERL91258.1 468 2.3e-44 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7835 BF_2 19.28 1.14 992 546681102 ERL91258.1 468 3.5e-44 hypothetical protein D910_08592 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7841 BF_2 44.95 1.90 1277 91085979 XP_971921.1 1520 4.6e-166 PREDICTED: flap endonuclease 1 [Tribolium castaneum]>gi|270009935|gb|EFA06383.1| hypothetical protein TcasGA2_TC009261 [Tribolium castaneum] -- -- -- -- -- K04799 FEN1, RAD2 flap endonuclease-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04799 Q178M1 1380 3.3e-151 Flap endonuclease 1 OS=Aedes aegypti GN=Fen1 PE=3 SV=1 PF00867//PF01367//PF00752 XPG I-region//5'-3' exonuclease, C-terminal SAM fold//XPG N-terminal domain GO:0006281//GO:0043137//GO:0006284//GO:0006308//GO:0090305 DNA repair//DNA replication, removal of RNA primer//base-excision repair//DNA catabolic process//nucleic acid phosphodiester bond hydrolysis GO:0017108//GO:0003824//GO:0003677//GO:0004518//GO:0000287//GO:0008409 5'-flap endonuclease activity//catalytic activity//DNA binding//nuclease activity//magnesium ion binding//5'-3' exonuclease activity GO:0005654//GO:0005739//GO:0005730 nucleoplasm//mitochondrion//nucleolus KOG2519 5'-3' exonuclease Cluster-8309.7843 BF_2 25.00 0.81 1578 820805586 AKG92784.1 923 9.6e-97 hand [Leptinotarsa decemlineata] -- -- -- -- -- K18486 HAND2 heart-and neural crest derivatives-expressed protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K18486 P57102 374 1.8e-34 Heart- and neural crest derivatives-expressed protein 2 OS=Danio rerio GN=hand2 PE=2 SV=1 PF00010//PF10863 Helix-loop-helix DNA-binding domain//Protein of unknown function (DUF2702) GO:0042274 ribosomal small subunit biogenesis GO:0046983 protein dimerization activity GO:0030686 90S preribosome -- -- Cluster-8309.7845 BF_2 3.78 0.31 794 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7846 BF_2 1.00 0.40 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.785 BF_2 2.00 0.68 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7856 BF_2 4.00 0.32 811 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7859 BF_2 36.33 1.12 1647 815921478 XP_012245620.1 185 3.8e-11 PREDICTED: chondroitin proteoglycan-2-like isoform X2 [Bombus impatiens] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.788 BF_2 2.00 0.46 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7888 BF_2 309.00 14.67 1168 166919247 ABZ04021.1 697 1.1e-70 serine protease 13 [Costelytra zealandica] -- -- -- -- -- K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 Q00871 528 1.9e-52 Chymotrypsin BI OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.7897 BF_2 16.00 2.07 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7899 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.790 BF_2 9.00 1.02 658 755853642 XP_011295530.1 148 2.9e-07 PREDICTED: nuclear protein 1 [Musca domestica] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03470 XS zinc finger domain GO:0031047 gene silencing by RNA -- -- -- -- -- -- Cluster-8309.7908 BF_2 1.00 0.51 366 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7916 BF_2 116.00 4.53 1359 91089203 XP_966829.1 1411 2.1e-153 PREDICTED: replication factor C subunit 3 [Tribolium castaneum]>gi|270012468|gb|EFA08916.1| hypothetical protein TcasGA2_TC006622 [Tribolium castaneum] 676459724 XM_009057146.1 56 4.49646e-18 Lottia gigantea hypothetical protein mRNA K10756 RFC3_5 replication factor C subunit 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K10756 P40938 1152 9.5e-125 Replication factor C subunit 3 OS=Homo sapiens GN=RFC3 PE=1 SV=2 PF14532//PF06068//PF00004//PF06144 Sigma-54 interaction domain//TIP49 C-terminus//ATPase family associated with various cellular activities (AAA)//DNA polymerase III, delta subunit GO:0006260//GO:0006355 DNA replication//regulation of transcription, DNA-templated GO:0008134//GO:0003887//GO:0003677//GO:0003678//GO:0005524//GO:0017111 transcription factor binding//DNA-directed DNA polymerase activity//DNA binding//DNA helicase activity//ATP binding//nucleoside-triphosphatase activity GO:0042575//GO:0005667//GO:0005657//GO:0009360 DNA polymerase complex//transcription factor complex//replication fork//DNA polymerase III complex KOG2035 Replication factor C, subunit RFC3 Cluster-8309.7927 BF_2 12.29 0.85 889 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.793 BF_2 13.00 3.20 457 56121719 AAV74196.1 601 6.1e-60 ribosomal protein L26 [Penaeus monodon]>gi|124295601|gb|ABN04203.1| ribosomal protein L26 [Litopenaeus vannamei] 262401435 FJ774900.1 132 8.1368e-61 Scylla paramamosain putative ribosomal protein L26e mRNA, partial cds K02898 RP-L26e, RPL26 large subunit ribosomal protein L26e http://www.genome.jp/dbget-bin/www_bget?ko:K02898 P61255 503 5.8e-50 60S ribosomal protein L26 OS=Mus musculus GN=Rpl26 PE=1 SV=1 PF16906 Ribosomal proteins L26 eukaryotic, L24P archaeal GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0015934 ribosome//large ribosomal subunit KOG3401 60S ribosomal protein L26 Cluster-8309.7933 BF_2 3.00 0.68 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00692 dUTPase GO:0046080 dUTP metabolic process GO:0016787 hydrolase activity -- -- -- -- Cluster-8309.7939 BF_2 2.93 1.73 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7940 BF_2 1.00 2.59 275 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7942 BF_2 7.81 0.34 1241 531446199 AGT57842.1 917 3.7e-96 cytochrome P450 302a1 [Leptinotarsa decemlineata] -- -- -- -- -- K10721 DIB CYP302A1; ecdysteroid 22-hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K10721 Q9NGX9 580 1.8e-58 Cytochrome P450 302a1, mitochondrial OS=Drosophila melanogaster GN=dib PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0020037//GO:0005506//GO:0016705 heme binding//iron ion binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.7948 BF_2 3.00 0.33 671 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.7952 BF_2 7.00 0.41 1006 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF12242//PF01370//PF00106 NAD(P)H binding domain of trans-2-enoyl-CoA reductase//NAD dependent epimerase/dehydratase family//short chain dehydrogenase GO:0008152//GO:0055114 metabolic process//oxidation-reduction process GO:0003824//GO:0050662//GO:0016491 catalytic activity//coenzyme binding//oxidoreductase activity -- -- -- -- Cluster-8309.7954 BF_2 9.01 0.35 1368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02984 Cyclin, C-terminal domain -- -- -- -- GO:0005634 nucleus -- -- Cluster-8309.7958 BF_2 15.00 2.91 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00520 Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216 ion channel activity GO:0016020 membrane -- -- Cluster-8309.7971 BF_2 102.45 3.38 1554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01496//PF06009//PF07851 V-type ATPase 116kDa subunit family//Laminin Domain II//TMPIT-like protein GO:0007155//GO:0015992//GO:0015991 cell adhesion//proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0016021//GO:0033179 integral component of membrane//proton-transporting V-type ATPase, V0 domain -- -- Cluster-8309.7989 BF_2 18.08 0.77 1275 91090027 XP_967605.1 473 1.2e-44 PREDICTED: uroporphyrinogen-III synthase [Tribolium castaneum]>gi|270013699|gb|EFA10147.1| hypothetical protein TcasGA2_TC012334 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P10746 234 2.5e-18 Uroporphyrinogen-III synthase OS=Homo sapiens GN=UROS PE=1 SV=1 PF02602 Uroporphyrinogen-III synthase HemD GO:0015994//GO:0033014//GO:0006783 chlorophyll metabolic process//tetrapyrrole biosynthetic process//heme biosynthetic process GO:0004852 uroporphyrinogen-III synthase activity -- -- -- -- Cluster-8309.7997 BF_2 4.00 0.37 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.7998 BF_2 182.00 4.77 1884 91095139 XP_973052.1 1169 3.4e-125 PREDICTED: methyltransferase-like protein 16 homolog [Tribolium castaneum]>gi|270015731|gb|EFA12179.1| hypothetical protein TcasGA2_TC002332 [Tribolium castaneum] -- -- -- -- -- K11393 METT10D methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K11393 Q6DC64 735 3.0e-76 Methyltransferase-like protein 16 OS=Danio rerio GN=mettl16 PE=2 SV=1 PF09445//PF05971//PF05175//PF08241//PF01596//PF02390 RNA cap guanine-N2 methyltransferase//Protein of unknown function (DUF890)//Methyltransferase small domain//Methyltransferase domain//O-methyltransferase//Putative methyltransferase GO:0006400//GO:0008033//GO:0009451//GO:0008152//GO:0009452//GO:0001510 tRNA modification//tRNA processing//RNA modification//metabolic process//7-methylguanosine RNA capping//RNA methylation GO:0008168//GO:0008176//GO:0008171 methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//O-methyltransferase activity -- -- KOG2912 Predicted DNA methylase Cluster-8309.7999 BF_2 37.00 0.56 3047 270001713 EEZ98160.1 3593 0.0e+00 hypothetical protein TcasGA2_TC000586 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q709C8 405 8.9e-38 Vacuolar protein sorting-associated protein 13C OS=Homo sapiens GN=VPS13C PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8013 BF_2 53.29 2.16 1321 357631657 EHJ79126.1 932 7.3e-98 hypothetical protein KGM_15588 [Danaus plexippus] 667677333 AE014297.3 84 1.1888e-33 Drosophila melanogaster chromosome 3R K19306 BUD23 18S rRNA (guanine1575-N7)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K19306 O43709 779 1.6e-81 Probable 18S rRNA (guanine-N(7))-methyltransferase OS=Homo sapiens GN=WBSCR22 PE=1 SV=2 PF01555//PF07757//PF08241 DNA methylase//Predicted AdoMet-dependent methyltransferase//Methyltransferase domain GO:0006306//GO:0008152 DNA methylation//metabolic process GO:0008170//GO:0003677//GO:0008168 N-methyltransferase activity//DNA binding//methyltransferase activity -- -- KOG1541 Predicted protein carboxyl methylase Cluster-8309.8022 BF_2 127.24 2.99 2066 642924019 XP_008193971.1 2158 7.8e-240 PREDICTED: von Willebrand factor A domain-containing protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q66KD9 1179 1.1e-127 von Willebrand factor A domain-containing protein 9 OS=Xenopus tropicalis GN=vwa9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8024 BF_2 16.76 0.61 1434 642924019 XP_008193971.1 1435 3.7e-156 PREDICTED: von Willebrand factor A domain-containing protein 9 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5EA76 731 6.6e-76 von Willebrand factor A domain-containing protein 9 OS=Bos taurus GN=VWA9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8025 BF_2 60.80 1.85 1660 642939704 XP_008201400.1 252 6.5e-19 PREDICTED: uncharacterized protein LOC103315176 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8028 BF_2 8.27 0.88 681 -- -- -- -- -- 462276874 APGK01059234.1 95 4.59243e-40 Dendroctonus ponderosae Seq01059244, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8030 BF_2 12.68 1.61 617 642913175 XP_008201423.1 543 4.3e-53 PREDICTED: uncharacterized protein LOC663955 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8046 BF_2 5.18 0.33 951 646701184 KDR11023.1 155 6.6e-08 Caspase-1 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- P89116 148 1.7e-08 Caspase-1 OS=Spodoptera frugiperda PE=1 SV=1 PF06374//PF00656 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2)//Caspase domain GO:0015992//GO:0006744//GO:0006508//GO:0006814//GO:0006120 proton transport//ubiquinone biosynthetic process//proteolysis//sodium ion transport//mitochondrial electron transport, NADH to ubiquinone GO:0008137//GO:0004197 NADH dehydrogenase (ubiquinone) activity//cysteine-type endopeptidase activity GO:0005743 mitochondrial inner membrane -- -- Cluster-8309.8048 BF_2 4.00 0.50 621 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13965 dsRNA-gated channel SID-1 GO:0033227//GO:0015931 dsRNA transport//nucleobase-containing compound transport GO:0051033 RNA transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.8055 BF_2 30.24 3.60 639 642928441 XP_008193786.1 225 3.4e-16 PREDICTED: uncharacterized protein LOC103313125 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8076 BF_2 3.00 0.39 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8078 BF_2 2.00 0.34 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.808 BF_2 19.00 3.71 501 328899728 AEB54646.1 776 3.4e-80 ribosomal protein S11 [Procambarus clarkii] 513011144 XM_004866922.1 145 5.32934e-68 PREDICTED: Heterocephalus glaber ribosomal protein S11 (Rps11), mRNA K02949 RP-S11e, RPS11 small subunit ribosomal protein S11e http://www.genome.jp/dbget-bin/www_bget?ko:K02949 P41115 650 5.7e-67 40S ribosomal protein S11 OS=Xenopus laevis GN=rps11 PE=2 SV=1 PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG1728 40S ribosomal protein S11 Cluster-8309.8084 BF_2 14.41 0.67 1182 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02232 Alpha trans-inducing protein (Alpha-TIF) GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.8085 BF_2 1.00 1.32 304 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8086 BF_2 10.00 0.96 725 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8087 BF_2 8.00 0.64 814 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8092 BF_2 27.00 1.58 1004 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8096 BF_2 3.00 0.33 668 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8097 BF_2 79.87 1.42 2642 91086211 XP_971977.1 951 9.1e-100 PREDICTED: HSPB1-associated protein 1 isoform X2 [Tribolium castaneum] -- -- -- -- -- K19375 HSPBAP1 HSPB1-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K19375 Q96EW2 500 7.4e-49 HSPB1-associated protein 1 OS=Homo sapiens GN=HSPBAP1 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG2132 Uncharacterized conserved protein, contains JmjC domain Cluster-8309.81 BF_2 4.00 0.34 779 91080535 XP_966772.1 452 2.0e-42 PREDICTED: protein mab-21 [Tribolium castaneum]>gi|270005804|gb|EFA02252.1| hypothetical protein TcasGA2_TC007915 [Tribolium castaneum] 641733571 XM_008158995.1 94 1.90192e-39 PREDICTED: Eptesicus fuscus mab-21-like 1 (C. elegans) (MAB21L1), mRNA -- -- -- -- Q5TW90 416 1.2e-39 Protein mab-21 OS=Anopheles gambiae GN=mab-21 PE=3 SV=3 -- -- GO:0045165 cell fate commitment -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.8106 BF_2 17.00 0.45 1875 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8115 BF_2 19.00 1.69 757 642922463 XP_008193182.1 223 6.8e-16 PREDICTED: integrin beta-PS [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11584 177 6.0e-12 Integrin beta-PS OS=Drosophila melanogaster GN=mys PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8124 BF_2 16.00 3.11 502 328899769 AEB54648.1 677 1.0e-68 ribosomal protein S19 [Procambarus clarkii] 262401358 FJ774861.1 290 1.326e-148 Scylla paramamosain ribosomal protein S19e mRNA, partial cds K02966 RP-S19e, RPS19 small subunit ribosomal protein S19e http://www.genome.jp/dbget-bin/www_bget?ko:K02966 Q94613 500 1.4e-49 40S ribosomal protein S19 OS=Mya arenaria GN=RPS19 PE=2 SV=1 PF01090 Ribosomal protein S19e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3411 40S ribosomal protein S19 Cluster-8309.8125 BF_2 24.33 1.35 1039 478254506 ENN74753.1 288 2.7e-23 hypothetical protein YQE_08661, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF06573//PF01363//PF00518//PF07776//PF05495 Churchill protein//FYVE zinc finger//Early Protein (E6)//Zinc-finger associated domain (zf-AD)//CHY zinc finger GO:0007275//GO:0045893 multicellular organismal development//positive regulation of transcription, DNA-templated GO:0046872//GO:0003677//GO:0008270 metal ion binding//DNA binding//zinc ion binding GO:0042025//GO:0005634 host cell nucleus//nucleus -- -- Cluster-8309.8127 BF_2 24.00 0.72 1678 820805556 AKG92769.1 627 2.1e-62 delilah [Leptinotarsa decemlineata] 642919336 XM_008193608.1 38 5.65933e-08 PREDICTED: Tribolium castaneum protein atonal homolog 7-like (LOC103312596), mRNA K09104 K09104 bHLH factor, other http://www.genome.jp/dbget-bin/www_bget?ko:K09104 P41894 260 3.2e-21 Helix-loop-helix protein delilah OS=Drosophila melanogaster GN=tx PE=1 SV=3 PF00010 Helix-loop-helix DNA-binding domain -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.8136 BF_2 65.00 3.03 1185 242018564 XP_002429744.1 259 7.1e-20 conserved hypothetical protein [Pediculus humanus corporis]>gi|212514756|gb|EEB17006.1| conserved hypothetical protein [Pediculus humanus corporis] -- -- -- -- -- K15708 RNF180 E3 ubiquitin-protein ligase RNF180 http://www.genome.jp/dbget-bin/www_bget?ko:K15708 Q5RAK3 172 3.6e-11 E3 ubiquitin-protein ligase RNF180 OS=Pongo abelii GN=RNF180 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8141 BF_2 38.61 2.62 904 189236906 XP_001809986.1 1051 7.9e-112 PREDICTED: palmitoyltransferase ZDHHC17 isoform X1 [Tribolium castaneum]>gi|270005015|gb|EFA01463.1| hypothetical protein TcasGA2_TC007009 [Tribolium castaneum] -- -- -- -- -- K18932 ZDHHC palmitoyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K18932 Q80TN5 662 4.2e-68 Palmitoyltransferase ZDHHC17 OS=Mus musculus GN=Zdhhc17 PE=1 SV=2 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0046872//GO:0005515//GO:0008270 metal ion binding//protein binding//zinc ion binding -- -- KOG0509 Ankyrin repeat and DHHC-type Zn-finger domain containing proteins Cluster-8309.8147 BF_2 90.41 2.51 1793 642927866 XP_008195431.1 968 6.6e-102 PREDICTED: ankyrin repeat and LEM domain-containing protein 1 [Tribolium castaneum]>gi|270010254|gb|EFA06702.1| hypothetical protein TcasGA2_TC009633 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NAG6 531 1.3e-52 Ankyrin repeat and LEM domain-containing protein 1 OS=Homo sapiens GN=ANKLE1 PE=2 SV=2 -- -- -- -- -- -- GO:0005635 nuclear envelope -- -- Cluster-8309.8154 BF_2 42.23 0.66 2952 531449435 AGT57858.1 237 6.3e-17 cytochrome P450 6ef1, partial [Leptinotarsa decemlineata] -- -- -- -- -- K14999 CYP6 cytochrome P450, family 6 http://www.genome.jp/dbget-bin/www_bget?ko:K14999 Q27593 200 5.1e-14 Cytochrome P450 6a8 OS=Drosophila melanogaster GN=Cyp6a8 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.8156 BF_2 61.06 0.90 3130 478258693 ENN78728.1 175 1.0e-09 hypothetical protein YQE_04800, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q27593 153 1.5e-08 Cytochrome P450 6a8 OS=Drosophila melanogaster GN=Cyp6a8 PE=2 SV=2 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0016705//GO:0005506//GO:0020037 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen//iron ion binding//heme binding -- -- -- -- Cluster-8309.8163 BF_2 1.00 15.15 223 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8165 BF_2 18.00 0.70 1368 828234423 XP_012566074.1 138 8.8e-06 PREDICTED: uncharacterized protein LOC105850137, partial [Hydra vulgaris] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8171 BF_2 13.00 0.48 1425 345452835 AEN94569.1 1056 3.3e-112 tetraspanin [Scylla paramamosain] 345452834 HQ260915.1 1239 0 Scylla paramamosain tetraspanin mRNA, complete cds -- -- -- -- Q58DM3 215 4.5e-16 Leukocyte surface antigen CD53 OS=Bos taurus GN=CD53 PE=2 SV=1 PF00335//PF06687 Tetraspanin family//SUR7/PalI family -- -- -- -- GO:0016021//GO:0005886 integral component of membrane//plasma membrane -- -- Cluster-8309.8176 BF_2 11.00 3.06 437 844843182 XP_012793763.1 226 1.8e-16 60S ribosomal protein L29, partial [Schistosoma haematobium]>gi|685957953|gb|KGB34004.1| 60S ribosomal protein L29, partial [Schistosoma haematobium] 392901673 NM_001268834.1 44 6.43279e-12 Caenorhabditis elegans RPL-29, isoform a (rpl-29), partial mRNA K02905 RP-L29e, RPL29 large subunit ribosomal protein L29e http://www.genome.jp/dbget-bin/www_bget?ko:K02905 Q58DW3 205 2.0e-15 60S ribosomal protein L29 OS=Bos taurus GN=RPL29 PE=2 SV=3 PF01779 Ribosomal L29e protein family GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3504 60S ribosomal protein L29 Cluster-8309.818 BF_2 4.00 0.63 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8180 BF_2 29.28 0.91 1630 642913508 XP_008201043.1 1218 6.2e-131 PREDICTED: corticotropin-releasing factor-binding protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q28557 366 1.6e-33 Corticotropin-releasing factor-binding protein OS=Ovis aries GN=CRHBP PE=2 SV=1 PF05428 Corticotropin-releasing factor binding protein (CRF-BP) -- -- GO:0051424 corticotropin-releasing hormone binding -- -- -- -- Cluster-8309.8194 BF_2 20.00 1.14 1023 270004639 EFA01087.1 375 2.2e-33 hypothetical protein TcasGA2_TC004010 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9V7U0 166 1.5e-10 Pro-resilin OS=Drosophila melanogaster GN=resilin PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.8198 BF_2 8.65 0.49 1020 91092412 XP_967539.1 564 2.6e-55 PREDICTED: tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like [Tribolium castaneum]>gi|270004747|gb|EFA01195.1| hypothetical protein TcasGA2_TC010522 [Tribolium castaneum] -- -- -- -- -- K05542 DUS1 tRNA-dihydrouridine synthase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K05542 Q6P1R4 295 1.7e-25 tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like OS=Homo sapiens GN=DUS1L PE=1 SV=1 PF04309//PF01207 Glycerol-3-phosphate responsive antiterminator//Dihydrouridine synthase (Dus) GO:0008033//GO:0055114//GO:0009607//GO:0006355//GO:0008152 tRNA processing//oxidation-reduction process//response to biotic stimulus//regulation of transcription, DNA-templated//metabolic process GO:0017150//GO:0050660 tRNA dihydrouridine synthase activity//flavin adenine dinucleotide binding -- -- KOG2335 tRNA-dihydrouridine synthase Cluster-8309.82 BF_2 14.00 0.98 884 478260323 ENN80074.1 1298 1.8e-140 hypothetical protein YQE_03490, partial [Dendroctonus ponderosae]>gi|478260325|gb|ENN80076.1| hypothetical protein YQE_03492, partial [Dendroctonus ponderosae] 815790887 XM_012360585.1 348 1.37604e-180 PREDICTED: Linepithema humile protein mab-21-like (LOC105668301), mRNA -- -- -- -- Q29H56 1169 6.6e-127 Protein mab-21 OS=Drosophila pseudoobscura pseudoobscura GN=mab-21 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG3963 Mab-21-like cell fate specification proteins Cluster-8309.8200 BF_2 9.00 0.63 886 829839363 XP_012635057.1 1379 7.2e-150 PREDICTED: 40S ribosomal protein S4, X isoform-like [Microcebus murinus] 156071482 NM_001007.4 886 0 Homo sapiens ribosomal protein S4, X-linked (RPS4X), mRNA K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 Q642H9 1312 1.7e-143 40S ribosomal protein S4, X isoform OS=Danio rerio GN=rps4x PE=2 SV=3 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8309.8201 BF_2 1.00 0.55 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8205 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.821 BF_2 3.00 0.55 514 546677206 ERL88085.1 158 1.6e-08 hypothetical protein D910_05474 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8210 BF_2 4.00 1.32 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8217 BF_2 1.00 1.37 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8229 BF_2 5.00 0.57 651 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8232 BF_2 0.22 5.12 213 478250888 ENN71375.1 217 9.4e-16 hypothetical protein YQE_11939 [Dendroctonus ponderosae] -- -- -- -- -- K12350 SMPD1, ASM sphingomyelin phosphodiesterase http://www.genome.jp/dbget-bin/www_bget?ko:K12350 Q0VD19 153 1.0e-09 Sphingomyelin phosphodiesterase OS=Bos taurus GN=SMPD1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8233 BF_2 47.00 1.53 1571 270002408 EEZ98855.1 570 8.2e-56 hypothetical protein TcasGA2_TC004465 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P93748 140 2.4e-07 Putative E3 ubiquitin-protein ligase SINAT1 OS=Arabidopsis thaliana GN=SINAT1 PE=3 SV=1 PF03145//PF02176 Seven in absentia protein family//TRAF-type zinc finger GO:0007275//GO:0006511 multicellular organismal development//ubiquitin-dependent protein catabolic process GO:0008270 zinc ion binding GO:0005634 nucleus -- -- Cluster-8309.8234 BF_2 140.00 4.72 1528 91084487 XP_971744.1 718 5.5e-73 PREDICTED: equilibrative nucleoside transporter 3 [Tribolium castaneum]>gi|270008874|gb|EFA05322.1| hypothetical protein TcasGA2_TC015480 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q80WK7 362 4.3e-33 Equilibrative nucleoside transporter 3 OS=Rattus norvegicus GN=Slc29a3 PE=1 SV=2 PF01733 Nucleoside transporter GO:0015858//GO:0006810 nucleoside transport//transport GO:0005337 nucleoside transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.8237 BF_2 2.00 0.41 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8238 BF_2 5.11 0.33 932 270013063 EFA09511.1 366 2.2e-32 hypothetical protein TcasGA2_TC011613 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8243 BF_2 13.57 0.40 1700 642920283 XP_008192282.1 1027 9.0e-109 PREDICTED: DNA-directed RNA polymerase III subunit RPC3 [Tribolium castaneum]>gi|270006046|gb|EFA02494.1| hypothetical protein TcasGA2_TC008189 [Tribolium castaneum] -- -- -- -- -- K03023 RPC3, POLR3C DNA-directed RNA polymerase III subunit RPC3 http://www.genome.jp/dbget-bin/www_bget?ko:K03023 Q9BUI4 486 2.0e-47 DNA-directed RNA polymerase III subunit RPC3 OS=Homo sapiens GN=POLR3C PE=1 SV=1 PF05645 RNA polymerase III subunit RPC82 GO:0006144//GO:0006206//GO:0006351 purine nucleobase metabolic process//pyrimidine nucleobase metabolic process//transcription, DNA-templated GO:0003677//GO:0003899 DNA binding//DNA-directed RNA polymerase activity GO:0005730 nucleolus KOG2587 RNA polymerase III (C) subunit Cluster-8309.8252 BF_2 17.85 2.17 632 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00042 Globin -- -- GO:0019825//GO:0020037 oxygen binding//heme binding -- -- -- -- Cluster-8309.8260 BF_2 31.41 2.12 907 642928019 XP_008200121.1 590 2.3e-58 PREDICTED: GPI ethanolamine phosphate transferase 3 [Tribolium castaneum] -- -- -- -- -- K05288 PIGO phosphatidylinositol glycan, class O http://www.genome.jp/dbget-bin/www_bget?ko:K05288 Q9JJI6 151 7.5e-09 GPI ethanolamine phosphate transferase 3 OS=Mus musculus GN=Pigo PE=1 SV=2 PF03600 Citrate transporter GO:0055085 transmembrane transport -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8265 BF_2 1.00 4.50 256 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8266 BF_2 30.99 0.67 2213 189235646 XP_968349.2 2067 3.0e-229 PREDICTED: peripheral plasma membrane protein CASK isoform X4 [Tribolium castaneum] 642917490 XM_963256.3 446 0 PREDICTED: Tribolium castaneum peripheral plasma membrane protein CASK (LOC656749), transcript variant X4, mRNA K06103 CASK calcium/calmodulin-dependent serine protein kinase http://www.genome.jp/dbget-bin/www_bget?ko:K06103 Q62915 1343 1.1e-146 Peripheral plasma membrane protein CASK OS=Rattus norvegicus GN=Cask PE=1 SV=1 PF00069//PF07714 Protein kinase domain//Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672//GO:0005524 protein kinase activity//ATP binding -- -- KOG0033 Ca2+/calmodulin-dependent protein kinase, EF-Hand protein superfamily Cluster-8309.8278 BF_2 1.00 2.66 274 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8280 BF_2 8.00 0.61 837 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01311//PF06463 Bacterial export proteins, family 1//Molybdenum Cofactor Synthesis C GO:0006605//GO:0006777 protein targeting//Mo-molybdopterin cofactor biosynthetic process GO:0051539 4 iron, 4 sulfur cluster binding GO:0016020//GO:0019008 membrane//molybdopterin synthase complex -- -- Cluster-8309.8290 BF_2 1.00 0.37 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8306 BF_2 334.57 6.06 2596 546684608 ERL94225.1 1767 2.1e-194 hypothetical protein D910_11506 [Dendroctonus ponderosae] -- -- -- -- -- K12655 OTUD5, DUBA OTU domain-containing protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K12655 Q640H3 747 1.7e-77 OTU domain-containing protein 5-B OS=Xenopus laevis GN=otud5-b PE=2 SV=1 -- -- -- -- -- -- -- -- KOG2605 OTU (ovarian tumor)-like cysteine protease Cluster-8309.831 BF_2 17.00 5.74 410 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8313 BF_2 72.16 0.95 3464 642923122 XP_008193618.1 2688 4.6e-301 PREDICTED: cyclic nucleotide-gated cation channel beta-1 [Tribolium castaneum]>gi|270007574|gb|EFA04022.1| hypothetical protein TcasGA2_TC014251 [Tribolium castaneum] -- -- -- -- -- K04952 CNGB1 cyclic nucleotide gated channel beta 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04952 Q28181 1066 2.3e-114 Cyclic nucleotide-gated cation channel beta-1 OS=Bos taurus GN=CNGB1 PE=1 SV=1 PF11789//PF00440//PF00520 Zinc-finger of the MIZ type in Nse subunit//Bacterial regulatory proteins, tetR family//Ion transport protein GO:0006811//GO:0055085 ion transport//transmembrane transport GO:0005216//GO:0008270//GO:0003677 ion channel activity//zinc ion binding//DNA binding GO:0016021//GO:0016020 integral component of membrane//membrane KOG0499 Cyclic nucleotide-gated cation channel CNCG4 Cluster-8309.8314 BF_2 19.00 7.09 398 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8324 BF_2 8.75 1.25 579 728418383 AIY68367.1 328 3.5e-28 esterase [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8328 BF_2 221.88 4.29 2449 270011827 EFA08275.1 1934 8.7e-214 hypothetical protein TcasGA2_TC005909 [Tribolium castaneum] -- -- -- -- -- K15332 TRMT2A tRNA (uracil-5-)-methyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K15332 Q8IZ69 1053 5.2e-113 tRNA (uracil-5-)-methyltransferase homolog A OS=Homo sapiens GN=TRMT2A PE=1 SV=2 PF01135//PF05175//PF02390//PF08241//PF02384//PF09445//PF05958//PF03602//PF00076//PF05401//PF01209 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)//Methyltransferase small domain//Putative methyltransferase//Methyltransferase domain//N-6 DNA Methylase//RNA cap guanine-N2 methyltransferase//tRNA (Uracil-5-)-methyltransferase//Conserved hypothetical protein 95//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Nodulation protein S (NodS)//ubiE/COQ5 methyltransferase family GO:0031167//GO:0006464//GO:0009312//GO:0008033//GO:0006396//GO:0008152//GO:0009452//GO:0001510//GO:0006400//GO:0046500//GO:0006306//GO:0009877//GO:0006479//GO:0009451 rRNA methylation//cellular protein modification process//oligosaccharide biosynthetic process//tRNA processing//RNA processing//metabolic process//7-methylguanosine RNA capping//RNA methylation//tRNA modification//S-adenosylmethionine metabolic process//DNA methylation//nodulation//protein methylation//RNA modification GO:0008168//GO:0008170//GO:0008173//GO:0003677//GO:0008757//GO:0008176//GO:0004719//GO:0003676 methyltransferase activity//N-methyltransferase activity//RNA methyltransferase activity//DNA binding//S-adenosylmethionine-dependent methyltransferase activity//tRNA (guanine-N7-)-methyltransferase activity//protein-L-isoaspartate (D-aspartate) O-methyltransferase activity//nucleic acid binding -- -- KOG2187 tRNA uracil-5-methyltransferase and related tRNA-modifying enzymes Cluster-8309.8330 BF_2 24.00 1.16 1156 189239979 XP_001808109.1 204 1.7e-13 PREDICTED: uncharacterized protein LOC100142168 [Tribolium castaneum]>gi|270011814|gb|EFA08262.1| hypothetical protein TcasGA2_TC005890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05552 150 1.2e-08 Transcription factor Adf-1 OS=Drosophila melanogaster GN=Adf1 PE=2 SV=2 PF02944 BESS motif -- -- GO:0003677 DNA binding -- -- -- -- Cluster-8309.8337 BF_2 13.00 0.71 1055 642926052 XP_970129.2 369 1.1e-32 PREDICTED: alpha-tocopherol transfer protein-like [Tribolium castaneum]>gi|270008991|gb|EFA05439.1| hypothetical protein TcasGA2_TC015616 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8BWP5 147 2.5e-08 Alpha-tocopherol transfer protein OS=Mus musculus GN=Ttpa PE=1 SV=1 PF06481 COX Aromatic Rich Motif GO:0006118//GO:0022900//GO:0055114 obsolete electron transport//electron transport chain//oxidation-reduction process GO:0008827 cytochrome o ubiquinol oxidase activity GO:0016021//GO:0009319 integral component of membrane//cytochrome o ubiquinol oxidase complex -- -- Cluster-8309.8339 BF_2 19.00 1.51 815 642931405 XP_008196566.1 318 7.1e-27 PREDICTED: uncharacterized protein LOC660374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8347 BF_2 183.83 2.04 4054 189234046 XP_968851.2 1200 1.9e-128 PREDICTED: uncharacterized protein LOC657290 isoform X1 [Tribolium castaneum] -- -- -- -- -- K06626 CCNE cyclin E http://www.genome.jp/dbget-bin/www_bget?ko:K06626 P54733 648 7.9e-66 G1/S-specific cyclin-E OS=Drosophila melanogaster GN=CycE PE=1 SV=2 PF02984//PF00554 Cyclin, C-terminal domain//Rel homology DNA-binding domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0003677 transcription factor activity, sequence-specific DNA binding//DNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0655 G1/S-specific cyclin E Cluster-8309.8348 BF_2 3.08 0.32 690 704187598 XP_010137671.1 154 6.2e-08 PREDICTED: ankyrin-1-like [Buceros rhinoceros silvestris] -- -- -- -- -- K12489 ACAP Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein http://www.genome.jp/dbget-bin/www_bget?ko:K12489 Q96P50 197 2.6e-14 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 3 OS=Homo sapiens GN=ACAP3 PE=1 SV=2 PF13606//PF00023//PF06344 Ankyrin repeat//Ankyrin repeat//Parechovirus Genome-linked protein -- -- GO:0005515 protein binding GO:0019015 viral genome -- -- Cluster-8309.8357 BF_2 12.54 2.26 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8358 BF_2 3.22 0.64 496 91084291 XP_971690.1 286 2.2e-23 PREDICTED: solute carrier family 28 member 3 [Tribolium castaneum]>gi|270008747|gb|EFA05195.1| hypothetical protein TcasGA2_TC015329 [Tribolium castaneum] -- -- -- -- -- K11536 SLC28A pyrimidine nucleoside transport protein http://www.genome.jp/dbget-bin/www_bget?ko:K11536 Q9UA35 221 3.1e-17 Solute carrier family 28 member 3 OS=Eptatretus stoutii GN=SLC28A3 PE=2 SV=1 -- -- GO:0006812//GO:0015858//GO:0006810 cation transport//nucleoside transport//transport GO:0005415 nucleoside:sodium symporter activity GO:0016020 membrane KOG3747 Concentrative Na+-nucleoside cotransporter CNT1/CNT2 Cluster-8309.8367 BF_2 3.00 0.37 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8377 BF_2 9.09 0.47 1095 270004731 EFA01179.1 309 1.0e-25 hypothetical protein TcasGA2_TC010502 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96PX8 150 1.2e-08 SLIT and NTRK-like protein 1 OS=Homo sapiens GN=SLITRK1 PE=1 SV=2 PF13855//PF00560 Leucine rich repeat//Leucine Rich Repeat -- -- GO:0005515 protein binding -- -- KOG0619 FOG: Leucine rich repeat Cluster-8309.8381 BF_2 16.00 0.89 1038 227018328 ACP18830.1 757 1.1e-77 cysteine proteinase 1 [Chrysomela tremula] -- -- -- -- -- K01365 CTSL cathepsin L http://www.genome.jp/dbget-bin/www_bget?ko:K01365 O97397 754 1.0e-78 Cathepsin L-like proteinase OS=Phaedon cochleariae PE=2 SV=1 PF00112//PF03051//PF11593 Papain family cysteine protease//Peptidase C1-like family//Mediator complex subunit 3 fungal GO:0006508//GO:0006357 proteolysis//regulation of transcription from RNA polymerase II promoter GO:0004197//GO:0001104//GO:0008234 cysteine-type endopeptidase activity//RNA polymerase II transcription cofactor activity//cysteine-type peptidase activity GO:0016592 mediator complex KOG1543 Cysteine proteinase Cathepsin L Cluster-8309.8384 BF_2 60.54 1.62 1846 675378821 KFM71723.1 516 1.8e-49 Zinc finger protein 271, partial [Stegodyphus mimosarum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P17035 484 3.7e-47 Zinc finger protein 28 OS=Homo sapiens GN=ZNF28 PE=2 SV=5 PF13912//PF01475//PF17123//PF15750//PF00096//PF13465 C2H2-type zinc finger//Ferric uptake regulator family//RING-like zinc finger//Ubiquitin-binding zinc-finger//Zinc finger, C2H2 type//Zinc-finger double domain GO:0006355 regulation of transcription, DNA-templated GO:0046872//GO:0005515//GO:0003700//GO:0008270//GO:0043130 metal ion binding//protein binding//transcription factor activity, sequence-specific DNA binding//zinc ion binding//ubiquitin binding GO:0005667 transcription factor complex -- -- Cluster-8309.8393 BF_2 66.00 1.86 1769 91084407 XP_967001.1 764 2.9e-78 PREDICTED: uncharacterized protein LOC655368 [Tribolium castaneum]>gi|270008706|gb|EFA05154.1| hypothetical protein TcasGA2_TC015272 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8394 BF_2 26.00 0.60 2093 478251184 ENN71660.1 722 2.6e-73 hypothetical protein YQE_11758, partial [Dendroctonus ponderosae]>gi|546682138|gb|ERL92119.1| hypothetical protein D910_09439 [Dendroctonus ponderosae] -- -- -- -- -- K19283 ACPP prostatic aicd phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K19283 Q3KQG9 542 7.9e-54 Testicular acid phosphatase homolog OS=Xenopus laevis GN=acpt PE=2 SV=1 PF00328 Histidine phosphatase superfamily (branch 2) GO:0019497//GO:0006771 hexachlorocyclohexane metabolic process//riboflavin metabolic process GO:0003993 acid phosphatase activity -- -- KOG3720 Lysosomal & prostatic acid phosphatases Cluster-8309.8403 BF_2 93.02 1.03 4083 642934150 XP_008199297.1 2776 3.2e-311 PREDICTED: lethal(3)malignant brain tumor-like protein 4 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96JM7 1376 3.0e-150 Lethal(3)malignant brain tumor-like protein 3 OS=Homo sapiens GN=L3MBTL3 PE=1 SV=2 PF11109//PF02198//PF01530//PF07647//PF00536//PF02820 Orexigenic neuropeptide Qrfp/P518//Sterile alpha motif (SAM)/Pointed domain//Zinc finger, C2HC type//SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif)//mbt repeat GO:0006355 regulation of transcription, DNA-templated GO:0005515//GO:0008270//GO:0043565//GO:0031854//GO:0003700 protein binding//zinc ion binding//sequence-specific DNA binding//orexigenic neuropeptide QRFP receptor binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0005667 nucleus//transcription factor complex -- -- Cluster-8309.8406 BF_2 13.52 0.64 1177 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.841 BF_2 4.00 0.39 712 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02076 Pheromone A receptor GO:0007186//GO:0007606//GO:0019236 G-protein coupled receptor signaling pathway//sensory perception of chemical stimulus//response to pheromone GO:0004932 mating-type factor pheromone receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.8412 BF_2 2.00 0.31 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8418 BF_2 6.00 0.53 759 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8425 BF_2 19.00 3.33 526 62860010 NP_001016602.1 691 2.6e-70 40S ribosomal protein S13 [Xenopus (Silurana) tropicalis]>gi|1350933|sp|P49393.2|RS13_XENLA RecName: Full=40S ribosomal protein S13 [Xenopus laevis]>gi|871774|emb|CAA90077.1| orf [Xenopus laevis]>gi|89269947|emb|CAJ81269.1| ribosomal protein S13 [Xenopus (Silurana) tropicalis]>gi|110645571|gb|AAI18691.1| rps13 protein [Xenopus (Silurana) tropicalis] 262401443 FJ774904.1 321 8.13571e-166 Scylla paramamosain ribosomal protein rps13 mRNA, partial cds K02953 RP-S13e, RPS13 small subunit ribosomal protein S13e http://www.genome.jp/dbget-bin/www_bget?ko:K02953 P49393 691 1.1e-71 40S ribosomal protein S13 OS=Xenopus laevis GN=rps13 PE=3 SV=2 PF00312//PF08069//PF00292 Ribosomal protein S15//Ribosomal S13/S15 N-terminal domain//'Paired box' domain GO:0042254//GO:0006412//GO:0006355 ribosome biogenesis//translation//regulation of transcription, DNA-templated GO:0003735//GO:0003677 structural constituent of ribosome//DNA binding GO:0005840//GO:0005622 ribosome//intracellular KOG0400 40S ribosomal protein S13 Cluster-8309.843 BF_2 2.00 0.35 529 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8434 BF_2 46.00 3.32 867 762100997 XP_011432966.1 1012 2.5e-107 PREDICTED: 40S ribosomal protein S2 [Crassostrea gigas] 338224339 HM217811.1 469 0 Scylla paramamosain ribosomal protein S2-like mRNA, partial sequence K02981 RP-S2e, RPS2 small subunit ribosomal protein S2e http://www.genome.jp/dbget-bin/www_bget?ko:K02981 P49154 992 2.2e-106 40S ribosomal protein S2 OS=Urechis caupo GN=RPS2 PE=2 SV=1 PF03719//PF00333 Ribosomal protein S5, C-terminal domain//Ribosomal protein S5, N-terminal domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003723//GO:0003735 RNA binding//structural constituent of ribosome GO:0005840 ribosome KOG0877 40S ribosomal protein S2/30S ribosomal protein S5 Cluster-8309.8436 BF_2 13.00 0.36 1792 326579691 ADZ96217.1 897 1.1e-93 JHE-like carboxylesterase 1 [Pandalopsis japonica] -- -- -- -- -- K03927 CES2 carboxylesterase 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03927 B2D0J5 657 3.1e-67 Venom carboxylesterase-6 OS=Apis mellifera PE=2 SV=1 PF00326//PF07859//PF04434 Prolyl oligopeptidase family//alpha/beta hydrolase fold//SWIM zinc finger GO:0008152//GO:0006508 metabolic process//proteolysis GO:0008270//GO:0016787//GO:0008236 zinc ion binding//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.844 BF_2 3.00 0.38 614 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8440 BF_2 120.87 0.68 7705 478254383 ENN74635.1 3286 0.0e+00 hypothetical protein YQE_08755, partial [Dendroctonus ponderosae] -- -- -- -- -- K02350 POLZ1, rev3 DNA polymerase zeta http://www.genome.jp/dbget-bin/www_bget?ko:K02350 Q61493 2447 3.7e-274 DNA polymerase zeta catalytic subunit OS=Mus musculus GN=Rev3l PE=1 SV=3 PF03104//PF02741//PF00136//PF13683 DNA polymerase family B, exonuclease domain//FTR, proximal lobe//DNA polymerase family B//Integrase core domain GO:0006730//GO:0015074 one-carbon metabolic process//DNA integration GO:0000166//GO:0008408//GO:0003677//GO:0016740 nucleotide binding//3'-5' exonuclease activity//DNA binding//transferase activity -- -- KOG0968 DNA polymerase zeta, catalytic subunit Cluster-8309.8458 BF_2 4.00 0.77 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8461 BF_2 9.00 1.21 597 270009519 EFA05967.1 363 3.1e-32 hypothetical protein TcasGA2_TC008787 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8463 BF_2 8.40 0.36 1252 642929846 XP_008195999.1 1267 9.8e-137 PREDICTED: anoctamin-8 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 601 6.8e-61 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 PF16178 Dimerisation domain of Ca+-activated chloride-channel, anoctamin -- -- GO:0046983 protein dimerization activity -- -- -- -- Cluster-8309.8465 BF_2 115.67 0.97 5296 642929846 XP_008195999.1 1855 2.7e-204 PREDICTED: anoctamin-8 [Tribolium castaneum] -- -- -- -- -- K19502 ANO8, TMEM16H anoctamin-8 http://www.genome.jp/dbget-bin/www_bget?ko:K19502 Q6PB70 790 3.5e-82 Anoctamin-8 OS=Mus musculus GN=Ano8 PE=2 SV=3 PF15724//PF16178 TMEM119 family//Dimerisation domain of Ca+-activated chloride-channel, anoctamin GO:0001503 ossification GO:0046983 protein dimerization activity -- -- KOG2513 Protein required for meiotic chromosome segregation Cluster-8309.8468 BF_2 3.00 0.40 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8471 BF_2 5.00 0.41 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8472 BF_2 34.39 1.03 1680 642937110 XP_008198695.1 324 2.9e-27 PREDICTED: major facilitator superfamily domain-containing protein 9-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8NBP5 185 1.6e-12 Major facilitator superfamily domain-containing protein 9 OS=Homo sapiens GN=MFSD9 PE=2 SV=2 PF00083//PF07690//PF01306 Sugar (and other) transporter//Major Facilitator Superfamily//LacY proton/sugar symporter GO:0006810//GO:0055085 transport//transmembrane transport GO:0022857 transmembrane transporter activity GO:0016020//GO:0016021 membrane//integral component of membrane -- -- Cluster-8309.8473 BF_2 23.52 0.98 1290 642931405 XP_008196566.1 638 8.8e-64 PREDICTED: uncharacterized protein LOC660374 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9BTX7 196 6.4e-14 Alpha-tocopherol transfer protein-like OS=Homo sapiens GN=TTPAL PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8480 BF_2 1.00 0.58 355 861611851 KMQ85376.1 315 6.9e-27 hypothetical protein RF55_16133 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8490 BF_2 6.00 0.44 862 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8497 BF_2 3.00 0.58 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8503 BF_2 2.00 0.33 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8507 BF_2 27.98 1.50 1069 91094195 XP_971373.1 955 1.3e-100 PREDICTED: uncharacterized protein C15orf41 homolog [Tribolium castaneum]>gi|270010852|gb|EFA07300.1| hypothetical protein TcasGA2_TC015890 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q6NRW5 509 2.7e-50 Uncharacterized protein C15orf41 homolog OS=Xenopus laevis PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8509 BF_2 11.32 0.56 1133 332373512 AEE61897.1 841 2.2e-87 unknown [Dendroctonus ponderosae]>gi|478261742|gb|ENN80889.1| hypothetical protein YQE_02678, partial [Dendroctonus ponderosae]>gi|546674326|gb|ERL85730.1| hypothetical protein D910_03145 [Dendroctonus ponderosae] -- -- -- -- -- K01074 PPT palmitoyl-protein thioesterase http://www.genome.jp/dbget-bin/www_bget?ko:K01074 Q9VKH6 661 6.8e-68 Lysosomal thioesterase PPT2 homolog OS=Drosophila melanogaster GN=Ppt2 PE=2 SV=1 PF02089 Palmitoyl protein thioesterase -- -- GO:0098599 palmitoyl hydrolase activity -- -- KOG2541 Palmitoyl protein thioesterase Cluster-8309.8510 BF_2 43.24 2.55 997 270003851 EFA00299.1 406 5.4e-37 hypothetical protein TcasGA2_TC003132 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF17082//PF08702//PF09177 Spindle Pole Component 29//Fibrinogen alpha/beta chain family//Syntaxin 6, N-terminal GO:0048193//GO:0030474//GO:0051258//GO:0007165//GO:0030168 Golgi vesicle transport//spindle pole body duplication//protein polymerization//signal transduction//platelet activation GO:0005102//GO:0030674//GO:0005200 receptor binding//protein binding, bridging//structural constituent of cytoskeleton GO:0005856//GO:0005577//GO:0016020//GO:0005823 cytoskeleton//fibrinogen complex//membrane//central plaque of spindle pole body -- -- Cluster-8309.8515 BF_2 17.00 0.40 2087 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8518 BF_2 5.00 0.58 647 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8533 BF_2 21.98 0.42 2483 642923008 XP_008200494.1 634 4.9e-63 PREDICTED: transcription factor elt-1-like isoform X5 [Tribolium castaneum] -- -- -- -- -- K17897 GATA6 GATA-binding protein 6 http://www.genome.jp/dbget-bin/www_bget?ko:K17897 P52168 279 3.0e-23 GATA-binding factor A OS=Drosophila melanogaster GN=pnr PE=1 SV=1 PF00320//PF01873//PF15200 GATA zinc finger//Domain found in IF2B/IF5//Keratinocyte differentiation-associated GO:0006446//GO:0006413//GO:0006355 regulation of translational initiation//translational initiation//regulation of transcription, DNA-templated GO:0003743//GO:0043565//GO:0008270//GO:0003700 translation initiation factor activity//sequence-specific DNA binding//zinc ion binding//transcription factor activity, sequence-specific DNA binding GO:0005667//GO:0005840//GO:0005576 transcription factor complex//ribosome//extracellular region KOG1601 GATA-4/5/6 transcription factors Cluster-8309.8541 BF_2 178.20 6.88 1371 189235517 XP_970938.2 1725 8.4e-190 PREDICTED: arf-GAP with dual PH domain-containing protein 1-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75689 954 8.7e-102 Arf-GAP with dual PH domain-containing protein 1 OS=Homo sapiens GN=ADAP1 PE=1 SV=2 PF01412 Putative GTPase activating protein for Arf -- -- GO:0005096 GTPase activator activity -- -- KOG0703 Predicted GTPase-activating protein Cluster-8309.8543 BF_2 30.00 1.53 1108 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8546 BF_2 27.07 3.49 612 546681839 ERL91854.1 281 1.0e-22 hypothetical protein D910_09179 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01284 Membrane-associating domain -- -- -- -- GO:0016020 membrane -- -- Cluster-8309.8549 BF_2 62.31 2.19 1475 332373478 AEE61880.1 814 3.9e-84 unknown [Dendroctonus ponderosae]>gi|478263741|gb|ENN82044.1| hypothetical protein YQE_01619, partial [Dendroctonus ponderosae]>gi|546670972|gb|ERL83504.1| hypothetical protein D910_00535 [Dendroctonus ponderosae]>gi|546679616|gb|ERL90053.1| hypothetical protein D910_07409 [Dendroctonus ponderosae] -- -- -- -- -- K00949 thiN, TPK1, THI80 thiamine pyrophosphokinase http://www.genome.jp/dbget-bin/www_bget?ko:K00949 Q9H3S4 487 1.3e-47 Thiamin pyrophosphokinase 1 OS=Homo sapiens GN=TPK1 PE=1 SV=1 PF04263//PF01341//PF04265 Thiamin pyrophosphokinase, catalytic domain//Glycosyl hydrolases family 6//Thiamin pyrophosphokinase, vitamin B1 binding domain GO:0006772//GO:0009229//GO:0005975//GO:0030245 thiamine metabolic process//thiamine diphosphate biosynthetic process//carbohydrate metabolic process//cellulose catabolic process GO:0004553//GO:0005524//GO:0004788//GO:0030975 hydrolase activity, hydrolyzing O-glycosyl compounds//ATP binding//thiamine diphosphokinase activity//thiamine binding -- -- KOG3153 Thiamine pyrophosphokinase Cluster-8309.8554 BF_2 2.00 0.54 441 221330674 NP_001137782.1 147 2.6e-07 shaker cognate w, isoform C [Drosophila melanogaster]>gi|220901931|gb|ACL82989.1| shaker cognate w, isoform C [Drosophila melanogaster] -- -- -- -- -- -- -- -- -- P17972 135 2.6e-07 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 -- -- GO:0006813//GO:0051260//GO:0030431//GO:0055085 potassium ion transport//protein homooligomerization//sleep//transmembrane transport GO:0005249 voltage-gated potassium channel activity GO:0008076 voltage-gated potassium channel complex -- -- Cluster-8309.8559 BF_2 23.84 1.45 976 91091562 XP_967054.1 381 4.2e-34 PREDICTED: mRNA turnover protein 4 homolog [Tribolium castaneum]>gi|270000914|gb|EEZ97361.1| hypothetical protein TcasGA2_TC011183 [Tribolium castaneum] -- -- -- -- -- K14815 MRT4 mRNA turnover protein 4 http://www.genome.jp/dbget-bin/www_bget?ko:K14815 Q9UKD2 334 4.8e-30 mRNA turnover protein 4 homolog OS=Homo sapiens GN=MRTO4 PE=1 SV=2 PF00466 Ribosomal protein L10 GO:0042254 ribosome biogenesis -- -- GO:0005622 intracellular KOG0816 Protein involved in mRNA turnover Cluster-8309.8567 BF_2 42.00 0.88 2275 642925115 XP_008194175.1 743 1.0e-75 PREDICTED: uncharacterized protein LOC103313218 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VA00 131 3.9e-06 Protein zwilch OS=Drosophila melanogaster GN=zwilch PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8577 BF_2 19.00 8.46 379 296489304 DAA31417.1 193 1.0e-12 TPA: polypyrimidine tract binding protein 2-like [Bos taurus] 30103059 AC139138.2 376 0 Homo sapiens chromosome 17, clone XXfos-82524G9, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8591 BF_2 48.68 0.99 2338 189240709 XP_001813711.1 1911 3.9e-211 PREDICTED: acyl-CoA synthetase family member 2, mitochondrial [Tribolium castaneum]>gi|270013541|gb|EFA09989.1| hypothetical protein TcasGA2_TC012154 [Tribolium castaneum] -- -- -- -- -- K00666 K00666 fatty-acyl-CoA synthase http://www.genome.jp/dbget-bin/www_bget?ko:K00666 Q0P4F7 1186 1.9e-128 Acyl-CoA synthetase family member 2, mitochondrial OS=Danio rerio GN=acsf2 PE=2 SV=1 PF08290//PF00501 Hepatitis core protein, putative zinc finger//AMP-binding enzyme GO:0009405//GO:0008152 pathogenesis//metabolic process GO:0005198//GO:0003824 structural molecule activity//catalytic activity -- -- KOG1176 Acyl-CoA synthetase Cluster-8309.8598 BF_2 109.91 1.36 3668 646718427 KDR20897.1 3344 0.0e+00 WD repeat-containing protein 35 [Zootermopsis nevadensis] 780035245 XM_778124.4 37 4.49815e-07 PREDICTED: Strongylocentrotus purpuratus WD repeat-containing protein 35 (LOC577925), transcript variant X3, mRNA -- -- -- -- A6N6J5 2981 0.0e+00 WD repeat-containing protein 35 OS=Rattus norvegicus GN=Wdr35 PE=1 SV=1 PF13181//PF04053//PF00637 Tetratricopeptide repeat//Coatomer WD associated region//Region in Clathrin and VPS GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG2503 Tubby superfamily protein TULP4 Cluster-8309.8600 BF_2 13.52 0.36 1867 270005448 EFA01896.1 983 1.3e-103 hypothetical protein TcasGA2_TC007506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q42524 698 5.8e-72 4-coumarate--CoA ligase 1 OS=Arabidopsis thaliana GN=4CL1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.8601 BF_2 159.51 4.38 1809 270005448 EFA01896.1 1215 1.5e-130 hypothetical protein TcasGA2_TC007506 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q42524 865 2.4e-91 4-coumarate--CoA ligase 1 OS=Arabidopsis thaliana GN=4CL1 PE=1 SV=1 PF00501 AMP-binding enzyme GO:0008152 metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8309.8612 BF_2 7.00 0.36 1100 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8620 BF_2 51.00 2.79 1052 383855073 XP_003703043.1 811 6.2e-84 PREDICTED: 60S ribosomal protein L7 [Megachile rotundata] 238477340 FJ478023.1 106 5.54651e-46 Rimicaris exoculata ribosomal protein L7 mRNA, partial cds K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 P32100 739 5.7e-77 60S ribosomal protein L7 OS=Drosophila melanogaster GN=RpL7 PE=1 SV=2 PF00336 DNA polymerase (viral) C-terminal domain GO:0051252 regulation of RNA metabolic process GO:0004523 RNA-DNA hybrid ribonuclease activity -- -- KOG3184 60S ribosomal protein L7 Cluster-8309.8635 BF_2 83.00 1.48 2641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8638 BF_2 10.19 0.53 1097 91079939 XP_968354.1 413 9.2e-38 PREDICTED: lysosomal alpha-mannosidase [Tribolium castaneum]>gi|270003259|gb|EEZ99706.1| hypothetical protein TcasGA2_TC002467 [Tribolium castaneum] -- -- -- -- -- K12311 MAN2B1, LAMAN lysosomal alpha-mannosidase http://www.genome.jp/dbget-bin/www_bget?ko:K12311 O09159 232 3.7e-18 Lysosomal alpha-mannosidase OS=Mus musculus GN=Man2b1 PE=2 SV=4 PF07748 Glycosyl hydrolases family 38 C-terminal domain GO:0006013//GO:0005975 mannose metabolic process//carbohydrate metabolic process GO:0015923//GO:0003824 mannosidase activity//catalytic activity -- -- KOG1959 Glycosyl hydrolase, family 38 - alpha-mannosidase Cluster-8309.8642 BF_2 16.21 1.22 845 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8644 BF_2 17.69 0.46 1906 780712889 XP_011704975.1 188 2.0e-11 PREDICTED: uncharacterized protein LOC105460239 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- -- -- -- -- PF04977//PF05485 Septum formation initiator//THAP domain GO:0007049 cell cycle GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.8646 BF_2 2.00 0.31 553 532059573 XP_005372459.1 169 9.0e-10 PREDICTED: serine/arginine repetitive matrix protein 1-like, partial [Microtus ochrogaster] 531997082 KC876030.1 465 0 Homo sapiens clone LA13_165F6 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8647 BF_2 9.00 0.46 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8658 BF_2 216.76 7.37 1517 332372618 AEE61451.1 898 7.3e-94 unknown [Dendroctonus ponderosae]>gi|478254395|gb|ENN74647.1| hypothetical protein YQE_08765, partial [Dendroctonus ponderosae]>gi|546682357|gb|ERL92305.1| hypothetical protein D910_09622 [Dendroctonus ponderosae] -- -- -- -- -- K15433 CGI99, CLE7, RLLM1 RLL motif containing protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K15433 Q9Y224 446 7.8e-43 UPF0568 protein C14orf166 OS=Homo sapiens GN=C14orf166 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG4380 Carnitine deficiency associated protein Cluster-8309.866 BF_2 6.00 1.60 444 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8661 BF_2 22.00 0.41 2511 642914220 XP_008201595.1 312 1.1e-25 PREDICTED: myb-like protein K [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03460 Nitrite/Sulfite reductase ferredoxin-like half domain GO:0055114 oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.8662 BF_2 3.00 0.51 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8664 BF_2 4.00 0.33 792 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8665 BF_2 24.00 1.58 922 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8666 BF_2 4.09 0.44 674 642929063 XP_008195676.1 227 2.1e-16 PREDICTED: flocculation protein FLO11 isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8675 BF_2 17.47 0.37 2284 546685251 ERL94778.1 1184 7.6e-127 hypothetical protein D910_12052, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9P2Q2 261 3.3e-21 FERM domain-containing protein 4A OS=Homo sapiens GN=FRMD4A PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8309.868 BF_2 14.00 0.70 1118 686773747 XP_002834824.3 1713 1.7e-188 PREDICTED: guanine nucleotide-binding protein subunit beta-2-like 1 [Pongo abelii] 12652914 BC000214.1 1115 0 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1, mRNA (cDNA clone MGC:2416 IMAGE:2959178), complete cds K14753 RACK1 guanine nucleotide-binding protein subunit beta-2-like 1 protein http://www.genome.jp/dbget-bin/www_bget?ko:K14753 P63247 1707 3.4e-189 Guanine nucleotide-binding protein subunit beta-2-like 1 OS=Gallus gallus GN=GNB2L1 PE=2 SV=1 PF00400 WD domain, G-beta repeat -- -- GO:0005515 protein binding -- -- KOG0279 G protein beta subunit-like protein Cluster-8309.8684 BF_2 22.00 0.66 1680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8686 BF_2 1.00 2.16 282 16950633 NP_446464.1 493 1.2e-47 argininosuccinate synthase [Homo sapiens]>gi|53759107|ref|NP_000041.2| argininosuccinate synthase [Homo sapiens]>gi|441623175|ref|XP_004088889.1| PREDICTED: argininosuccinate synthase isoform X2 [Nomascus leucogenys]>gi|530427178|ref|XP_005272257.1| PREDICTED: argininosuccinate synthase isoform X1 [Homo sapiens]>gi|20141195|sp|P00966.2|ASSY_HUMAN RecName: Full=Argininosuccinate synthase; AltName: Full=Citrulline--aspartate ligase>gi|14328059|gb|AAH09243.1| Argininosuccinate synthetase 1 [Homo sapiens]>gi|18203822|gb|AAH21676.1| Argininosuccinate synthetase 1 [Homo sapiens]>gi|19482138|gb|AAK67487.1| argininosuccinate synthetase [Homo sapiens]>gi|119608338|gb|EAW87932.1| argininosuccinate synthetase, isoform CRA_a [Homo sapiens]>gi|119608341|gb|EAW87935.1| argininosuccinate synthetase, isoform CRA_a [Homo sapiens]>gi|189054708|dbj|BAG37558.1| unnamed protein product [Homo sapiens]>gi|190690279|gb|ACE86914.1| argininosuccinate synthetase 1 protein [synthetic construct]>gi|190691653|gb|ACE87601.1| argininosuccinate synthetase 1 protein [synthetic construct]>gi|261858400|dbj|BAI45722.1| argininosuccinate synthetase 1 [synthetic construct]>gi|649098592|gb|AIC48313.1| ASS1, partial [synthetic construct]>gi|649117562|gb|AIC54043.1| ASS1, partial [synthetic construct] 823671327 KR710493.1 282 1.97127e-144 Synthetic construct Homo sapiens clone CCSBHm_00013413 ASS1 (ASS1) mRNA, encodes complete protein K01940 argG, ASS1 argininosuccinate synthase http://www.genome.jp/dbget-bin/www_bget?ko:K01940 P00966 493 5.1e-49 Argininosuccinate synthase OS=Homo sapiens GN=ASS1 PE=1 SV=2 PF00764 Arginosuccinate synthase GO:0071418//GO:0071400//GO:0060416//GO:0071242//GO:0001889//GO:0071230//GO:0006526//GO:0071549//GO:0071377//GO:0006953//GO:0060539//GO:0007568//GO:0000050//GO:0010046//GO:0001822//GO:0007584//GO:0006531//GO:0042493//GO:0071222//GO:0007494//GO:0071346//GO:0071356//GO:0000053//GO:0006955//GO:0010043//GO:0071320//GO:0006560//GO:0006522//GO:0032355 cellular response to amine stimulus//cellular response to oleic acid//response to growth hormone//cellular response to ammonium ion//liver development//cellular response to amino acid stimulus//arginine biosynthetic process//cellular response to dexamethasone stimulus//cellular response to glucagon stimulus//acute-phase response//diaphragm development//aging//urea cycle//response to mycotoxin//kidney development//response to nutrient//aspartate metabolic process//response to drug//cellular response to lipopolysaccharide//midgut development//cellular response to interferon-gamma//cellular response to tumor necrosis factor//argininosuccinate metabolic process//immune response//response to zinc ion//cellular response to cAMP//proline metabolic process//alanine metabolic process//response to estradiol GO:0005524//GO:0015643//GO:0005515//GO:0004055 ATP binding//toxic substance binding//protein binding//argininosuccinate synthase activity GO:0005829//GO:0019814//GO:0043204//GO:0005764//GO:0005634//GO:0070852//GO:0005783//GO:0005741 cytosol//immunoglobulin complex//perikaryon//lysosome//nucleus//cell body fiber//endoplasmic reticulum//mitochondrial outer membrane KOG1706 Argininosuccinate synthase Cluster-8309.8689 BF_2 20.00 0.41 2349 642922414 XP_008193147.1 914 1.6e-95 PREDICTED: transcription factor Sox-3 [Tribolium castaneum]>gi|270008206|gb|EFA04654.1| SoxNeuro [Tribolium castaneum] 751217116 XM_011163231.1 110 7.53202e-48 PREDICTED: Solenopsis invicta transcription factor Sox-3 (LOC105197035), transcript variant X3, mRNA K09267 SOX1S transcription factor SOX1/3/14/21 (SOX group B) http://www.genome.jp/dbget-bin/www_bget?ko:K09267 Q68FA4 438 1.0e-41 Transcription factor Sox-3 OS=Xenopus tropicalis GN=sox3 PE=2 SV=1 PF12336 SOX transcription factor GO:0006355 regulation of transcription, DNA-templated -- -- -- -- KOG0527 HMG-box transcription factor Cluster-8309.8690 BF_2 50.22 1.34 1858 642916330 XP_008190976.1 694 4.0e-70 PREDICTED: intracellular protein transport protein USO1-like isoform X1 [Tribolium castaneum]>gi|270004190|gb|EFA00638.1| hypothetical protein TcasGA2_TC003514 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25386 149 2.6e-08 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF02183//PF10473 Homeobox associated leucine zipper//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GO:0006355 regulation of transcription, DNA-templated GO:0045502//GO:0008134//GO:0003700//GO:0043565//GO:0042803 dynein binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//protein homodimerization activity GO:0005667//GO:0030286 transcription factor complex//dynein complex -- -- Cluster-8309.8693 BF_2 2.00 0.60 425 700894663 AIU99750.1 272 7.9e-22 mitochondrial cytochrome c oxidase subunit VIc [Litopenaeus vannamei] -- -- -- -- -- K02268 COX6C cytochrome c oxidase subunit 6c http://www.genome.jp/dbget-bin/www_bget?ko:K02268 P80977 198 1.2e-14 Cytochrome c oxidase subunit 6C-1 OS=Thunnus obesus PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8695 BF_2 2.00 1.55 334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8709 BF_2 44.35 0.86 2454 642936506 XP_008198464.1 2042 2.6e-226 PREDICTED: LOW QUALITY PROTEIN: alpha-2C adrenergic receptor [Tribolium castaneum] -- -- -- -- -- K04140 ADRA2C adrenergic receptor alpha-2C http://www.genome.jp/dbget-bin/www_bget?ko:K04140 Q90WY6 475 5.5e-46 Alpha-2C adrenergic receptor OS=Danio rerio GN=adra2c PE=3 SV=1 PF00001//PF01080 7 transmembrane receptor (rhodopsin family)//Presenilin GO:0007186 G-protein coupled receptor signaling pathway GO:0004930//GO:0004190 G-protein coupled receptor activity//aspartic-type endopeptidase activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.8720 BF_2 9.00 0.42 1185 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8721 BF_2 2.00 0.37 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8722 BF_2 49.64 0.31 7036 642939568 XP_001808071.2 861 6.6e-89 PREDICTED: uncharacterized protein LOC100141755 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03137 Organic Anion Transporter Polypeptide (OATP) family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8309.8724 BF_2 4.00 0.57 582 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8725 BF_2 28.67 0.34 3856 270000924 EEZ97371.1 386 4.4e-34 hypothetical protein TcasGA2_TC011194 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00646//PF15966//PF13516//PF12937 F-box domain//F-box//Leucine Rich repeat//F-box-like -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8736 BF_2 5.00 0.32 944 429535130 CCE73651.2 1372 4.9e-149 chymotrypsin-like proteinase [Scylla paramamosain] 429535129 HE614125.2 908 0 Scylla paramamosain mRNA for chymotrypsin-like proteinase (spchy gene) K01312 PRSS trypsin http://www.genome.jp/dbget-bin/www_bget?ko:K01312 P36178 1094 3.5e-118 Chymotrypsin BII OS=Litopenaeus vannamei PE=1 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.874 BF_2 7.00 0.44 950 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06390 Neuroendocrine-specific golgi protein P55 (NESP55) GO:0071107 response to parathyroid hormone -- -- -- -- -- -- Cluster-8309.8742 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.875 BF_2 12.07 0.31 1915 270009144 EFA05592.1 589 6.2e-58 hypothetical protein TcasGA2_TC015795 [Tribolium castaneum] -- -- -- -- -- K10177 TBX3 T-box protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K10177 Q24432 298 1.4e-25 Optomotor-blind protein OS=Drosophila melanogaster GN=bi PE=1 SV=3 PF00907//PF06624 T-box//Ribosome associated membrane protein RAMP4 GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005783//GO:0005667//GO:0005634 endoplasmic reticulum//transcription factor complex//nucleus KOG3585 TBX2 and related T-box transcription factors Cluster-8309.8756 BF_2 81.00 0.58 6169 642933339 XP_008197373.1 4467 0.0e+00 PREDICTED: roundabout homolog 2 [Tribolium castaneum] -- -- -- -- -- K06753 ROBO1 roundabout, axon guidance receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K06753 O89026 1384 5.4e-151 Roundabout homolog 1 OS=Mus musculus GN=Robo1 PE=1 SV=1 PF15957//PF13895//PF00041 Commissureless//Immunoglobulin domain//Fibronectin type III domain GO:0007411 axon guidance GO:0005515 protein binding -- -- KOG4222 Axon guidance receptor Dscam Cluster-8309.8763 BF_2 114.00 3.12 1817 642916582 XP_008191780.1 1039 3.9e-110 PREDICTED: transcription initiation protein SPT3 homolog [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O75486 280 1.7e-23 Transcription initiation protein SPT3 homolog OS=Homo sapiens GN=SUPT3H PE=1 SV=2 PF01592//PF02269 NifU-like N terminal domain//Transcription initiation factor IID, 18kD subunit GO:0016226//GO:0006366 iron-sulfur cluster assembly//transcription from RNA polymerase II promoter GO:0051536//GO:0005506 iron-sulfur cluster binding//iron ion binding -- -- -- -- Cluster-8309.8771 BF_2 13.00 0.54 1298 91080169 XP_970176.1 714 1.4e-72 PREDICTED: protein abnormal spindle [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VC45 349 1.2e-31 Protein abnormal spindle OS=Drosophila melanogaster GN=asp PE=1 SV=3 PF00612 IQ calmodulin-binding motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8772 BF_2 1.00 0.74 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8773 BF_2 29.00 1.33 1196 170053246 XP_001862585.1 382 3.9e-34 microtubule binding protein [Culex quinquefasciatus]>gi|167873840|gb|EDS37223.1| microtubule binding protein [Culex quinquefasciatus] -- -- -- -- -- K16743 ASPM, ASP abnormal spindle-like microcephaly-associated protein http://www.genome.jp/dbget-bin/www_bget?ko:K16743 Q9VC45 346 2.4e-31 Protein abnormal spindle OS=Drosophila melanogaster GN=asp PE=1 SV=3 PF00307 Calponin homology (CH) domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8775 BF_2 29.68 1.03 1487 478255317 ENN75543.1 159 3.5e-08 hypothetical protein YQE_07886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.878 BF_2 10.00 1.26 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8783 BF_2 1.00 0.37 399 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8786 BF_2 10.00 3.86 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8792 BF_2 3.00 0.51 535 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8797 BF_2 9.00 0.36 1327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8800 BF_2 6.22 0.35 1037 332373854 AEE62068.1 526 6.8e-51 unknown [Dendroctonus ponderosae] 642918806 XM_008193372.1 79 5.582e-31 PREDICTED: Tribolium castaneum serine/threonine-protein phosphatase PP1-alpha-like (LOC103312533), mRNA K06269 PPP1C serine/threonine-protein phosphatase PP1 catalytic subunit http://www.genome.jp/dbget-bin/www_bget?ko:K06269 Q9UW86 449 2.4e-43 Serine/threonine-protein phosphatase PP1 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=pph-3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0374 Serine/threonine specific protein phosphatase PP1, catalytic subunit Cluster-8309.8816 BF_2 19.82 0.36 2580 642915691 XP_008190761.1 3006 0.0e+00 PREDICTED: cyclic nucleotide-gated cation channel subunit A [Tribolium castaneum] 170060746 XM_001865903.1 397 0 Culex quinquefasciatus cyclic-nucleotide-gated cation channel, mRNA K04950 CNGA3 cyclic nucleotide gated channel alpha 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04950 Q24278 2169 2.1e-242 Cyclic nucleotide-gated cation channel subunit A OS=Drosophila melanogaster GN=CngA PE=2 SV=2 PF05929//PF02173//PF00520 Phage capsid scaffolding protein (GPO) serine peptidase//pKID domain//Ion transport protein GO:0006355//GO:0055085//GO:0019069//GO:0006811 regulation of transcription, DNA-templated//transmembrane transport//viral capsid assembly//ion transport GO:0005216//GO:0005515 ion channel activity//protein binding GO:0016020 membrane KOG0500 Cyclic nucleotide-gated cation channel CNGA1-3 and related proteins Cluster-8309.8818 BF_2 22.00 0.64 1723 402715413 1PDZ 2131 8.8e-237 Chain A, X-Ray Structure And Catalytic Mechanism Of Lobster Enolase>gi|408489435|pdb|1PDY|A Chain A, X-Ray Structure And Catalytic Mechanism Of Lobster Enolase 41394398 AY522936.1 976 0 Callinectes sapidus 2-phospho-D-glycerate hydrolase mRNA, partial cds K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 P56252 2131 3.6e-238 Enolase OS=Homarus gammarus PE=1 SV=1 PF00113//PF03952 Enolase, C-terminal TIM barrel domain//Enolase, N-terminal domain GO:0006096//GO:0009094//GO:0006094//GO:0006571//GO:0000162 glycolytic process//L-phenylalanine biosynthetic process//gluconeogenesis//tyrosine biosynthetic process//tryptophan biosynthetic process GO:0004634//GO:0000287 phosphopyruvate hydratase activity//magnesium ion binding GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-8309.8820 BF_2 86.36 7.06 799 189237193 XP_001808466.1 604 4.8e-60 PREDICTED: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 [Tribolium castaneum] -- -- -- -- -- K09008 NDUFAF3 NADH dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K09008 A1L1F1 260 1.5e-21 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3 OS=Danio rerio GN=ndufaf3 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3363 Uncharacterized conserved nuclear protein Cluster-8309.8822 BF_2 3.00 0.62 490 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8825 BF_2 62.50 3.34 1071 642914660 XP_974035.2 503 3.3e-48 PREDICTED: transmembrane protein 230 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q8CIB6 284 3.4e-24 Transmembrane protein 230 OS=Mus musculus GN=Tmem230 PE=1 SV=1 PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane KOG4753 Predicted membrane protein Cluster-8309.8827 BF_2 20.00 0.93 1183 282403497 NP_001164145.1 773 1.8e-79 caspase-like protein [Tribolium castaneum]>gi|642916782|ref|XP_008199500.1| PREDICTED: caspase-like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O08738 250 3.2e-20 Caspase-6 OS=Mus musculus GN=Casp6 PE=2 SV=1 PF00656 Caspase domain GO:0006508 proteolysis GO:0004197 cysteine-type endopeptidase activity -- -- KOG3573 Caspase, apoptotic cysteine protease Cluster-8309.883 BF_2 4.00 0.46 648 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8831 BF_2 66.00 14.68 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8835 BF_2 16.05 0.63 1350 215274049 ACJ64922.1 1886 1.8e-208 nicotinic acetylcholine receptor alpha 8 [Leptinotarsa decemlineata] 584600389 KF873592.1 337 2.77248e-174 Locusta migratoria strain Js nicotinic acetylcholine receptor alpha8 variant D mRNA, complete cds, alternatively spliced K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P25162 1443 1.7e-158 Acetylcholine receptor subunit beta-like 2 OS=Drosophila melanogaster GN=nAChRbeta2 PE=2 SV=3 PF02932//PF02931 Neurotransmitter-gated ion-channel transmembrane region//Neurotransmitter-gated ion-channel ligand binding domain GO:0006810//GO:0006811 transport//ion transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3645 Acetylcholine receptor Cluster-8309.8841 BF_2 31.01 1.30 1284 642936495 XP_008198460.1 253 3.8e-19 PREDICTED: protein tantalus isoform X2 [Tribolium castaneum]>gi|642936497|ref|XP_008198461.1| PREDICTED: protein tantalus isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8849 BF_2 63.95 0.33 8311 642934007 XP_008197600.1 1043 6.2e-110 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] 584600633 EU595402.2 44 1.3158e-10 Drosophila virilis kl-2 1-beta dynein heavy chain mRNA, partial cds K10408 DNAH dynein heavy chain, axonemal http://www.genome.jp/dbget-bin/www_bget?ko:K10408 P0C6F1 763 7.4e-79 Dynein heavy chain 2, axonemal OS=Mus musculus GN=Dnah2 PE=2 SV=1 PF02993//PF00008//PF03028//PF01467 Minor capsid protein VI//EGF-like domain//Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like GO:0007018//GO:0009058//GO:0007017 microtubule-based movement//biosynthetic process//microtubule-based process GO:0003777//GO:0005515//GO:0003824 microtubule motor activity//protein binding//catalytic activity GO:0005874//GO:0030286//GO:0019028 microtubule//dynein complex//viral capsid KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.8851 BF_2 116.78 2.66 2124 642934007 XP_008197600.1 1055 6.4e-112 PREDICTED: nicotinamide mononucleotide adenylyltransferase 1 [Tribolium castaneum] -- -- -- -- -- K06210 NMNAT nicotinamide mononucleotide adenylyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K06210 Q9EPA7 633 2.3e-64 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 OS=Mus musculus GN=Nmnat1 PE=1 SV=2 PF03028//PF01467//PF00008 Dynein heavy chain and region D6 of dynein motor//Cytidylyltransferase-like//EGF-like domain GO:0007018//GO:0009058//GO:0007017 microtubule-based movement//biosynthetic process//microtubule-based process GO:0005515//GO:0003777//GO:0003824 protein binding//microtubule motor activity//catalytic activity GO:0005874//GO:0030286 microtubule//dynein complex KOG3199 Nicotinamide mononucleotide adenylyl transferase Cluster-8309.8854 BF_2 8.88 0.61 892 270001677 EEZ98124.1 609 1.4e-60 hypothetical protein TcasGA2_TC000544 [Tribolium castaneum] -- -- -- -- -- K12323 ANPRA, NPR1 atrial natriuretic peptide receptor A http://www.genome.jp/dbget-bin/www_bget?ko:K12323 Q9VEU5 423 2.1e-40 Soluble guanylate cyclase 89Db OS=Drosophila melanogaster GN=Gyc-89Db PE=1 SV=1 PF00211//PF00089 Adenylate and Guanylate cyclase catalytic domain//Trypsin GO:0035556//GO:0009190//GO:0006508 intracellular signal transduction//cyclic nucleotide biosynthetic process//proteolysis GO:0004252//GO:0016849 serine-type endopeptidase activity//phosphorus-oxygen lyase activity -- -- KOG1023 Natriuretic peptide receptor, guanylate cyclase Cluster-8309.8856 BF_2 2.00 0.44 478 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8859 BF_2 4.00 0.68 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8864 BF_2 40.50 2.48 970 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8870 BF_2 4.00 1.44 402 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8871 BF_2 15.29 1.98 610 478253482 ENN73809.1 449 3.4e-42 hypothetical protein YQE_09587, partial [Dendroctonus ponderosae]>gi|546679134|gb|ERL89639.1| hypothetical protein D910_07004 [Dendroctonus ponderosae] 645007869 XM_001600661.3 78 1.15295e-30 PREDICTED: Nasonia vitripennis adrenodoxin-like protein, mitochondrial (LOC100118135), mRNA -- -- -- -- P37193 398 1.2e-37 Adrenodoxin-like protein, mitochondrial OS=Drosophila melanogaster GN=Fdxh PE=2 SV=3 PF09749 Uncharacterised conserved protein GO:0034477 U6 snRNA 3'-end processing GO:0004518 nuclease activity -- -- KOG3309 Ferredoxin Cluster-8309.8883 BF_2 8.14 2.73 411 646465981 KDQ65252.1 225 2.2e-16 hypothetical protein L798_00087, partial [Zootermopsis nevadensis]>gi|646718091|gb|KDR20693.1| hypothetical protein L798_04842, partial [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8885 BF_2 16.86 1.24 857 270007766 EFA04214.1 378 8.2e-34 hypothetical protein TcasGA2_TC014463 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8886 BF_2 19.00 0.99 1092 642923819 XP_008193893.1 777 5.7e-80 PREDICTED: leukocyte surface antigen CD53-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00335 Tetraspanin family -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.8887 BF_2 9.00 0.45 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8891 BF_2 5.00 0.66 602 478253184 ENN73555.1 477 1.9e-45 hypothetical protein YQE_09805, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- P35368 134 4.6e-07 Alpha-1B adrenergic receptor OS=Homo sapiens GN=ADRA1B PE=1 SV=3 PF00001//PF00866 7 transmembrane receptor (rhodopsin family)//Ring hydroxylating beta subunit GO:0007186//GO:0055114//GO:0006725 G-protein coupled receptor signaling pathway//oxidation-reduction process//cellular aromatic compound metabolic process GO:0003824//GO:0004930 catalytic activity//G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.8897 BF_2 48.92 1.96 1329 642914595 XP_008190278.1 956 1.2e-100 PREDICTED: DNA topoisomerase 2-binding protein 1-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K10728 TOPBP1 topoisomerase (DNA) II binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10728 Q92547 262 1.5e-21 DNA topoisomerase 2-binding protein 1 OS=Homo sapiens GN=TOPBP1 PE=1 SV=3 PF00926 3,4-dihydroxy-2-butanone 4-phosphate synthase GO:0009231 riboflavin biosynthetic process GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity -- -- KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component Cluster-8309.8898 BF_2 8.86 0.33 1398 642914595 XP_008190278.1 953 2.8e-100 PREDICTED: DNA topoisomerase 2-binding protein 1-B isoform X1 [Tribolium castaneum] -- -- -- -- -- K10728 TOPBP1 topoisomerase (DNA) II binding protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K10728 Q92547 262 1.6e-21 DNA topoisomerase 2-binding protein 1 OS=Homo sapiens GN=TOPBP1 PE=1 SV=3 PF00926//PF05975 3,4-dihydroxy-2-butanone 4-phosphate synthase//Bacterial ABC transporter protein EcsB GO:0009231 riboflavin biosynthetic process GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity GO:0016021 integral component of membrane KOG1929 Nucleotide excision repair factor NEF2, RAD4/CUT5 component Cluster-8309.8902 BF_2 112.00 7.57 906 478259048 ENN78991.1 666 3.5e-67 hypothetical protein YQE_04542, partial [Dendroctonus ponderosae]>gi|546678361|gb|ERL88994.1| hypothetical protein D910_06372 [Dendroctonus ponderosae] -- -- -- -- -- K13348 MPV17 protein Mpv17 http://www.genome.jp/dbget-bin/www_bget?ko:K13348 Q6DIY8 368 5.2e-34 Mpv17-like protein 2 OS=Xenopus tropicalis GN=mpv17l2 PE=2 SV=1 PF04117 Mpv17 / PMP22 family -- -- -- -- GO:0016021 integral component of membrane KOG1944 Peroxisomal membrane protein MPV17 and related proteins Cluster-8309.8906 BF_2 10.00 0.61 978 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8908 BF_2 73.00 2.00 1812 528477962 XP_003198585.2 347 6.8e-30 PREDICTED: zinc finger protein 665-like [Danio rerio] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P51508 310 5.5e-27 Zinc finger protein 81 OS=Homo sapiens GN=ZNF81 PE=1 SV=3 PF07776//PF13912//PF03547//PF10426//PF00096//PF00569//PF13465 Zinc-finger associated domain (zf-AD)//C2H2-type zinc finger//Membrane transport protein//Recombination-activating protein 1 zinc-finger domain//Zinc finger, C2H2 type//Zinc finger, ZZ type//Zinc-finger double domain GO:0055085 transmembrane transport GO:0046872//GO:0016881//GO:0008270//GO:0016788 metal ion binding//acid-amino acid ligase activity//zinc ion binding//hydrolase activity, acting on ester bonds GO:0005634//GO:0016021 nucleus//integral component of membrane -- -- Cluster-8309.8912 BF_2 53.00 9.73 515 861651269 KMQ97685.1 283 5.1e-23 endocuticle structural glycoprotein bd-1-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- O02388 256 2.8e-21 Larval cuticle protein LCP-22 OS=Bombyx mori GN=LCP22 PE=2 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.8918 BF_2 8.78 1.26 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00537 Scorpion toxin-like domain GO:0006810 transport GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.8924 BF_2 9.00 0.68 844 321478948 EFX89904.1 381 3.6e-34 hypothetical protein DAPPUDRAFT_230075 [Daphnia pulex] -- -- -- -- -- K03098 APOD apolipoprotein D and lipocalin family protein http://www.genome.jp/dbget-bin/www_bget?ko:K03098 Q8SPI0 280 7.7e-24 Apolipoprotein D OS=Macaca fascicularis GN=APOD PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8925 BF_2 7.61 0.31 1307 675373661 KFM66563.1 238 2.1e-17 Mid1-interacting protein 1-B, partial [Stegodyphus mimosarum] -- -- -- -- -- -- -- -- -- Q8AWD1 133 1.3e-06 Mid1-interacting protein 1-like OS=Danio rerio GN=mid1ip1l PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8927 BF_2 14.00 0.32 2111 642911569 XP_008199479.1 1567 2.7e-171 PREDICTED: lachesin-like [Tribolium castaneum] 642911568 XM_008201257.1 351 0 PREDICTED: Tribolium castaneum lachesin-like (LOC661397), mRNA -- -- -- -- Q24372 300 9.2e-26 Lachesin OS=Drosophila melanogaster GN=Lac PE=1 SV=2 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.8930 BF_2 1.00 0.37 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8946 BF_2 3.00 30.32 233 -- -- -- -- -- 269812125 GU138663.1 215 2.79882e-107 Pythium ultimum culture-collection CBS:398.51 mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8952 BF_2 111.51 2.88 1908 332372834 AEE61559.1 640 7.6e-64 unknown [Dendroctonus ponderosae]>gi|478263633|gb|ENN81939.1| hypothetical protein YQE_01650, partial [Dendroctonus ponderosae]>gi|546672369|gb|ERL84268.1| hypothetical protein D910_01649 [Dendroctonus ponderosae]>gi|546682306|gb|ERL92259.1| hypothetical protein D910_09576 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q9D0B6 413 6.6e-39 Protein PBDC1 OS=Mus musculus GN=Pbdc1 PE=2 SV=1 PF02900 Catalytic LigB subunit of aromatic ring-opening dioxygenase GO:0006725 cellular aromatic compound metabolic process GO:0008198//GO:0016491 ferrous iron binding//oxidoreductase activity -- -- KOG4093 Uncharacterized conserved protein Cluster-8309.8954 BF_2 39.45 1.13 1748 642914252 XP_008201607.1 1667 5.7e-183 PREDICTED: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase [Tribolium castaneum]>gi|270001550|gb|EEZ97997.1| hypothetical protein TcasGA2_TC000395 [Tribolium castaneum] -- -- -- -- -- K00741 B3GNT1, B3GNT2 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00741 O43505 417 2.1e-39 Beta-1,4-glucuronyltransferase 1 OS=Homo sapiens GN=B4GAT1 PE=1 SV=1 PF04544 Herpesvirus egress protein UL20 GO:0019058 viral life cycle -- -- -- -- KOG3765 Predicted glycosyltransferase Cluster-8309.8958 BF_2 17.53 0.57 1581 270007206 EFA03654.1 657 6.7e-66 hypothetical protein TcasGA2_TC013748 [Tribolium castaneum] -- -- -- -- -- K14388 SLC5A8_12, SMCT solute carrier family 5 (sodium-coupled monocarboxylate transporter), member 8/12 http://www.genome.jp/dbget-bin/www_bget?ko:K14388 Q8N695 271 1.6e-22 Sodium-coupled monocarboxylate transporter 1 OS=Homo sapiens GN=SLC5A8 PE=1 SV=2 PF09036 Bcr-Abl oncoprotein oligomerisation domain GO:0007165//GO:0016310//GO:0009069//GO:0006468 signal transduction//phosphorylation//serine family amino acid metabolic process//protein phosphorylation GO:0005096//GO:0004674 GTPase activator activity//protein serine/threonine kinase activity -- -- -- -- Cluster-8309.8975 BF_2 66.10 0.84 3584 478250370 ENN70865.1 993 1.7e-104 hypothetical protein YQE_12271, partial [Dendroctonus ponderosae]>gi|546672860|gb|ERL84583.1| hypothetical protein D910_02012 [Dendroctonus ponderosae] -- -- -- -- -- K13704 ABHD12 abhydrolase domain-containing protein 12 http://www.genome.jp/dbget-bin/www_bget?ko:K13704 Q08C93 625 3.2e-63 Monoacylglycerol lipase ABHD12 OS=Danio rerio GN=abhd12 PE=2 SV=1 PF00975//PF07859//PF02230//PF00326//PF01764 Thioesterase domain//alpha/beta hydrolase fold//Phospholipase/Carboxylesterase//Prolyl oligopeptidase family//Lipase (class 3) GO:0008152//GO:0006508//GO:0009058//GO:0006629 metabolic process//proteolysis//biosynthetic process//lipid metabolic process GO:0016788//GO:0016787//GO:0008236 hydrolase activity, acting on ester bonds//hydrolase activity//serine-type peptidase activity -- -- -- -- Cluster-8309.8976 BF_2 14.00 0.50 1466 752863744 XP_011268239.1 246 2.8e-18 PREDICTED: uncharacterized protein LOC105258591 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF02796 helix-turn-helix, Psq domain//Helix-turn-helix domain of resolvase GO:0006310 DNA recombination GO:0000150//GO:0003677 recombinase activity//DNA binding -- -- -- -- Cluster-8309.898 BF_2 14.48 2.17 566 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8982 BF_2 21.66 0.39 2615 642937862 XP_008200329.1 2102 3.1e-233 PREDICTED: PHD finger protein 19 [Tribolium castaneum]>gi|270000755|gb|EEZ97202.1| hypothetical protein TcasGA2_TC004391 [Tribolium castaneum] -- -- -- -- -- K11485 MTF2, PCL2 polycomb-like protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K11485 Q9Y483 739 1.4e-76 Metal-response element-binding transcription factor 2 OS=Homo sapiens GN=MTF2 PE=1 SV=2 PF00130//PF05191//PF00628 Phorbol esters/diacylglycerol binding domain (C1 domain)//Adenylate kinase, active site lid//PHD-finger GO:0046034//GO:0006144//GO:0035556 ATP metabolic process//purine nucleobase metabolic process//intracellular signal transduction GO:0005515//GO:0004017 protein binding//adenylate kinase activity -- -- -- -- Cluster-8309.8983 BF_2 1.00 0.35 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.8989 BF_2 135.16 1.43 4233 91078890 XP_973183.1 1472 5.6e-160 PREDICTED: GTP-binding protein Rhes [Tribolium castaneum]>gi|270004145|gb|EFA00593.1| hypothetical protein TcasGA2_TC003464 [Tribolium castaneum] -- -- -- -- -- K07843 RASD1 RAS, dexamethasone-induced Ras-related protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07843 O35626 616 4.2e-62 Dexamethasone-induced Ras-related protein 1 OS=Mus musculus GN=Rasd1 PE=1 SV=1 PF00025//PF00071//PF08477 ADP-ribosylation factor family//Ras family//Ras of Complex, Roc, domain of DAPkinase GO:0006184//GO:0007264 obsolete GTP catabolic process//small GTPase mediated signal transduction GO:0005525//GO:0003924 GTP binding//GTPase activity GO:0016020 membrane -- -- Cluster-8309.8991 BF_2 31.03 0.41 3448 167234455 NP_001107843.1 1160 6.9e-124 torso-like protein precursor [Tribolium castaneum]>gi|642919627|ref|XP_008191996.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919629|ref|XP_008191997.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|642919631|ref|XP_008191998.1| PREDICTED: torso-like protein isoform X1 [Tribolium castaneum]>gi|270006436|gb|EFA02884.1| torso-like protein [Tribolium castaneum] -- -- -- -- -- K12377 TSL torso-like protein http://www.genome.jp/dbget-bin/www_bget?ko:K12377 P40689 806 3.2e-84 Torso-like protein OS=Drosophila melanogaster GN=tsl PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8309.8995 BF_2 7.47 0.32 1260 817079938 XP_012262407.1 565 2.5e-55 PREDICTED: U3 small nucleolar ribonucleoprotein protein MPP10 [Athalia rosae] -- -- -- -- -- K14559 MPP10 U3 small nucleolar RNA-associated protein MPP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14559 Q810V0 449 2.9e-43 U3 small nucleolar ribonucleoprotein protein MPP10 OS=Mus musculus GN=Mphosph10 PE=1 SV=2 PF01679//PF04006//PF01896 Proteolipid membrane potential modulator//Mpp10 protein//Eukaryotic and archaeal DNA primase small subunit GO:0006364//GO:0006269//GO:0006351 rRNA processing//DNA replication, synthesis of RNA primer//transcription, DNA-templated GO:0003896 DNA primase activity GO:0005730//GO:0005732//GO:0005657//GO:0005634//GO:0016021//GO:0034457 nucleolus//small nucleolar ribonucleoprotein complex//replication fork//nucleus//integral component of membrane//Mpp10 complex KOG2600 U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p Cluster-8309.8996 BF_2 150.53 3.40 2142 91088181 XP_972542.1 1048 4.2e-111 PREDICTED: U3 small nucleolar ribonucleoprotein protein MPP10 [Tribolium castaneum]>gi|270011840|gb|EFA08288.1| hypothetical protein TcasGA2_TC005922 [Tribolium castaneum] -- -- -- -- -- K14559 MPP10 U3 small nucleolar RNA-associated protein MPP10 http://www.genome.jp/dbget-bin/www_bget?ko:K14559 Q810V0 631 3.9e-64 U3 small nucleolar ribonucleoprotein protein MPP10 OS=Mus musculus GN=Mphosph10 PE=1 SV=2 PF04006//PF01679 Mpp10 protein//Proteolipid membrane potential modulator GO:0006364 rRNA processing -- -- GO:0005634//GO:0016021//GO:0005732//GO:0034457 nucleus//integral component of membrane//small nucleolar ribonucleoprotein complex//Mpp10 complex KOG2600 U3 small nucleolar ribonucleoprotein (snoRNP) subunit - Mpp10p Cluster-8309.90 BF_2 2.00 1.12 358 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9001 BF_2 72.97 0.31 10240 270011730 EFA08178.1 1458 5.7e-158 hypothetical protein TcasGA2_TC005805 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q7TN88 338 1.8e-29 Polycystic kidney disease protein 1-like 2 OS=Mus musculus GN=Pkd1l2 PE=2 SV=1 PF06160//PF01477//PF05393//PF00520 Septation ring formation regulator, EzrA//PLAT/LH2 domain//Human adenovirus early E3A glycoprotein//Ion transport protein GO:0000921//GO:0055085//GO:0006811 septin ring assembly//transmembrane transport//ion transport GO:0005515//GO:0005216 protein binding//ion channel activity GO:0005940//GO:0016021//GO:0016020 septin ring//integral component of membrane//membrane KOG3599 Ca2+-modulated nonselective cation channel polycystin Cluster-8309.9005 BF_2 4.00 0.35 769 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9013 BF_2 6.00 0.49 803 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9020 BF_2 3.00 0.89 428 642916891 XP_008199544.1 490 4.2e-47 PREDICTED: WASH complex subunit strumpellin [Tribolium castaneum] -- -- -- -- -- K18464 RTSC, SPG8 WASH complex subunit strumpellin http://www.genome.jp/dbget-bin/www_bget?ko:K18464 Q6DIP9 390 6.8e-37 WASH complex subunit strumpellin OS=Xenopus tropicalis PE=2 SV=1 PF10266 Hereditary spastic paraplegia protein strumpellin -- -- -- -- GO:0071203 WASH complex -- -- Cluster-8309.9022 BF_2 178.00 2.19 3683 270003095 EEZ99542.1 2510 2.1e-280 hypothetical protein TcasGA2_TC000124 [Tribolium castaneum] -- -- -- -- -- K18464 RTSC, SPG8 WASH complex subunit strumpellin http://www.genome.jp/dbget-bin/www_bget?ko:K18464 Q8C2E7 1919 3.0e-213 WASH complex subunit strumpellin OS=Mus musculus GN=Kiaa0196 PE=2 SV=2 PF10266 Hereditary spastic paraplegia protein strumpellin -- -- -- -- GO:0071203 WASH complex KOG3666 Uncharacterized conserved protein Cluster-8309.9025 BF_2 3.03 0.47 557 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04272 Phospholamban GO:0006816//GO:0006810 calcium ion transport//transport GO:0005246//GO:0042030 calcium channel regulator activity//ATPase inhibitor activity GO:0016020 membrane -- -- Cluster-8309.9026 BF_2 4.00 0.76 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03558 TBSV core protein P21/P22 -- -- -- -- GO:0019028 viral capsid -- -- Cluster-8309.9029 BF_2 29.89 0.39 3495 752892473 XP_011264323.1 1503 1.2e-163 PREDICTED: POU domain, class 6, transcription factor 2 isoform X1 [Camponotus floridanus] 817056495 XM_012413689.1 192 2.93639e-93 PREDICTED: Athalia rosae POU domain, class 6, transcription factor 1 (LOC105693636), mRNA K09368 POU6F POU domain transcription factor, class 6 http://www.genome.jp/dbget-bin/www_bget?ko:K09368 Q8BJI4 680 1.3e-69 POU domain, class 6, transcription factor 2 OS=Mus musculus GN=Pou6f2 PE=2 SV=1 PF00046//PF00157 Homeobox domain//Pou domain - N-terminal to homeobox domain GO:0006355 regulation of transcription, DNA-templated GO:0003677//GO:0003700 DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.9032 BF_2 2.00 0.39 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9036 BF_2 12.00 0.45 1410 607353959 EZA48640.1 173 8.0e-10 hypothetical protein X777_13603 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9037 BF_2 122.74 1.76 3197 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9040 BF_2 2.00 0.33 544 307175218 EFN65284.1 194 1.1e-12 hypothetical protein EAG_04622, partial [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9044 BF_2 2.00 0.34 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9050 BF_2 83.18 0.33 10821 642938407 XP_008191056.1 12388 0.0e+00 PREDICTED: protein unc-80 homolog [Tribolium castaneum] 642938406 XM_008192834.1 1336 0 PREDICTED: Tribolium castaneum protein unc-80 homolog (LOC103312362), mRNA -- -- -- -- Q9VB11 6395 0.0e+00 Protein unc-80 homolog OS=Drosophila melanogaster GN=CG18437 PE=3 SV=4 PF06305 Protein of unknown function (DUF1049) -- -- -- -- GO:0005887 integral component of plasma membrane -- -- Cluster-8309.9051 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9068 BF_2 103.00 8.92 770 270009598 EFA06046.1 302 4.8e-25 hypothetical protein TcasGA2_TC008878 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q08DU8 192 1.1e-13 Biogenesis of lysosome-related organelles complex 1 subunit 6 OS=Bos taurus GN=BLOC1S6 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9076 BF_2 4.00 0.46 654 861599125 KMQ83546.1 286 2.9e-23 transposase-like protein [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9077 BF_2 20.26 0.35 2706 642933004 XP_008197224.1 830 1.0e-85 PREDICTED: uncharacterized protein LOC658601 [Tribolium castaneum]>gi|270011458|gb|EFA07906.1| hypothetical protein TcasGA2_TC005481 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00858//PF04610 Amiloride-sensitive sodium channel//TrbL/VirB6 plasmid conjugal transfer protein GO:0030255//GO:0006814//GO:0006810 protein secretion by the type IV secretion system//sodium ion transport//transport GO:0005272 sodium channel activity GO:0016020 membrane -- -- Cluster-8309.9081 BF_2 13.00 0.49 1393 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9086 BF_2 3.00 4.11 302 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9091 BF_2 19.00 0.55 1745 149062108 EDM12531.1 160 3.2e-08 rCG48520 [Rattus norvegicus]>gi|149062109|gb|EDM12532.1| rCG48522, isoform CRA_a [Rattus norvegicus] 764020144 NR_002819.3 1745 0 Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9097 BF_2 156.00 4.77 1655 332373042 AEE61662.1 1012 4.8e-107 unknown [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q28596 133 1.7e-06 Thyrotropin-releasing hormone receptor OS=Ovis aries GN=TRHR PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.9099 BF_2 15.96 0.34 2256 189236498 XP_975203.2 2093 2.9e-232 PREDICTED: protein lin-9 homolog isoform X1 [Tribolium castaneum] 817204910 XM_012422927.1 153 9.02668e-72 PREDICTED: Orussus abietinus protein lin-9 homolog (LOC105698571), transcript variant X4, mRNA -- -- -- -- Q8C735 1086 7.1e-117 Protein lin-9 homolog OS=Mus musculus GN=Lin9 PE=2 SV=2 PF06584//PF05460 DIRP//Origin recognition complex subunit 6 (ORC6) GO:0006260//GO:0006351//GO:0007049 DNA replication//transcription, DNA-templated//cell cycle GO:0003677 DNA binding GO:0005664//GO:0017053 nuclear origin of replication recognition complex//transcriptional repressor complex -- -- Cluster-8309.91 BF_2 10.00 0.40 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9118 BF_2 2.89 0.34 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9119 BF_2 10.00 0.31 1649 642938930 XP_008200093.1 146 1.3e-06 PREDICTED: LOW QUALITY PROTEIN: probable cytochrome P450 6a23 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF15681 Lymphocyte activation family X GO:0006955//GO:0051249 immune response//regulation of lymphocyte activation -- -- -- -- -- -- Cluster-8309.9124 BF_2 10.00 0.33 1549 270016741 EFA13187.1 277 7.6e-22 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485//PF05699//PF08998 THAP domain//hAT family C-terminal dimerisation region//Bacterial epsilon antitoxin GO:0031342//GO:0009636//GO:0006955 negative regulation of cell killing//response to toxic substance//immune response GO:0015643//GO:0046983//GO:0003676 toxic substance binding//protein dimerization activity//nucleic acid binding GO:0019814 immunoglobulin complex -- -- Cluster-8309.9131 BF_2 10.00 1.22 630 290909033 ADD70031.1 670 8.3e-68 minus-C odorant binding protein 2 [Batocera horsfieldi] 290909032 GU575295.1 429 0 Batocera horsfieldi minus-C odorant binding protein 2 mRNA, complete cds -- -- -- -- P54193 136 2.9e-07 General odorant-binding protein 83a OS=Drosophila melanogaster GN=Obp83a PE=1 SV=1 PF01395 PBP/GOBP family -- -- GO:0005549 odorant binding -- -- -- -- Cluster-8309.9133 BF_2 17.61 0.79 1216 91077176 XP_972262.1 337 6.6e-29 PREDICTED: ras-like GTP-binding protein RHO [Tribolium castaneum]>gi|642913564|ref|XP_008201064.1| PREDICTED: ras-like GTP-binding protein RHO [Tribolium castaneum]>gi|270001708|gb|EEZ98155.1| hypothetical protein TcasGA2_TC000581 [Tribolium castaneum] -- -- -- -- -- K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 Q41253 312 2.2e-27 Rac-like GTP-binding protein RAC13 OS=Gossypium hirsutum GN=RAC13 PE=2 SV=1 PF00071//PF12641//PF00025//PF02421//PF08477 Ras family//Flavodoxin domain//ADP-ribosylation factor family//Ferrous iron transport protein B//Ras of Complex, Roc, domain of DAPkinase GO:0015684//GO:0007264 ferrous iron transport//small GTPase mediated signal transduction GO:0015093//GO:0010181//GO:0005525 ferrous iron transmembrane transporter activity//FMN binding//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.9135 BF_2 107.39 5.12 1165 91077176 XP_972262.1 367 2.1e-32 PREDICTED: ras-like GTP-binding protein RHO [Tribolium castaneum]>gi|642913564|ref|XP_008201064.1| PREDICTED: ras-like GTP-binding protein RHO [Tribolium castaneum]>gi|270001708|gb|EEZ98155.1| hypothetical protein TcasGA2_TC000581 [Tribolium castaneum] -- -- -- -- -- K04392 RAC1 Ras-related C3 botulinum toxin substrate 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04392 Q41253 342 6.9e-31 Rac-like GTP-binding protein RAC13 OS=Gossypium hirsutum GN=RAC13 PE=2 SV=1 PF08477//PF01926//PF02421//PF00025//PF00071 Ras of Complex, Roc, domain of DAPkinase//50S ribosome-binding GTPase//Ferrous iron transport protein B//ADP-ribosylation factor family//Ras family GO:0007264//GO:0015684 small GTPase mediated signal transduction//ferrous iron transport GO:0015093//GO:0005525 ferrous iron transmembrane transporter activity//GTP binding GO:0016021 integral component of membrane -- -- Cluster-8309.9138 BF_2 29.00 0.56 2436 478258088 ENN78226.1 809 2.5e-83 hypothetical protein YQE_05377, partial [Dendroctonus ponderosae]>gi|546682772|gb|ERL92661.1| hypothetical protein D910_09973 [Dendroctonus ponderosae] 90101487 DQ416766.1 48 2.28323e-13 Branchiostoma floridae gastrulation brain homeobox (Gbx) mRNA, complete cds K09321 GBX homeobox protein GBX http://www.genome.jp/dbget-bin/www_bget?ko:K09321 Q28ZA9 422 7.6e-40 Homeobox protein unplugged OS=Drosophila pseudoobscura pseudoobscura GN=unpg PE=3 SV=1 PF00046//PF05920 Homeobox domain//Homeobox KN domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8309.9147 BF_2 4.00 0.35 762 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9148 BF_2 20.83 1.33 941 270001572 EEZ98019.1 622 4.6e-62 hypothetical protein TcasGA2_TC000419 [Tribolium castaneum] 642914197 XM_008203364.1 167 6.08368e-80 PREDICTED: Tribolium castaneum uncharacterized LOC661711 (LOC661711), transcript variant X2, mRNA -- -- -- -- Q5TGI4 319 2.6e-28 Sterile alpha motif domain-containing protein 5 OS=Homo sapiens GN=SAMD5 PE=3 SV=1 PF00536//PF07647 SAM domain (Sterile alpha motif)//SAM domain (Sterile alpha motif) -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9154 BF_2 1.00 0.74 337 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9160 BF_2 3.00 0.85 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9164 BF_2 33.00 1.08 1565 642921183 XP_008192750.1 761 5.8e-78 PREDICTED: uncharacterized protein LOC103312840 isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9169 BF_2 3.00 0.39 608 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.917 BF_2 1.00 0.96 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9170 BF_2 47.67 0.72 3064 546676199 ERL87266.1 878 3.1e-91 hypothetical protein D910_04662 [Dendroctonus ponderosae] -- -- -- -- -- K15001 CYP4 cytochrome P450, family 4 http://www.genome.jp/dbget-bin/www_bget?ko:K15001 P29981 406 6.8e-38 Cytochrome P450 4C1 OS=Blaberus discoidalis GN=CYP4C1 PE=2 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8309.9176 BF_2 35.30 0.77 2204 270013728 EFA10176.1 2504 6.3e-280 hypothetical protein TcasGA2_TC012366 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 454 1.3e-43 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00096//PF13465 Zinc finger, C2H2 type//Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.9177 BF_2 20.06 0.36 2609 270013728 EFA10176.1 2268 1.7e-252 hypothetical protein TcasGA2_TC012366 [Tribolium castaneum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q86XU0 454 1.6e-43 Zinc finger protein 677 OS=Homo sapiens GN=ZNF677 PE=2 SV=1 PF00651//PF13465//PF00096//PF02214//PF03931 BTB/POZ domain//Zinc-finger double domain//Zinc finger, C2H2 type//BTB/POZ domain//Skp1 family, tetramerisation domain GO:0006511//GO:0051260 ubiquitin-dependent protein catabolic process//protein homooligomerization GO:0046872//GO:0005515 metal ion binding//protein binding -- -- -- -- Cluster-8309.9191 BF_2 2.00 9.01 256 748389318 KIH61239.1 223 2.3e-16 hypothetical protein ANCDUO_08493 [Ancylostoma duodenale] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05840 Bacteriophage replication gene A protein (GPA) GO:0006260 DNA replication -- -- -- -- -- -- Cluster-8309.9192 BF_2 2.00 0.40 498 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9193 BF_2 4.00 0.43 675 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9199 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9203 BF_2 32.85 0.75 2111 91090228 XP_968551.1 525 1.8e-50 PREDICTED: uncharacterized protein LOC656965 [Tribolium castaneum]>gi|270013773|gb|EFA10221.1| hypothetical protein TcasGA2_TC012417 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00642 Zinc finger C-x8-C-x5-C-x3-H type (and similar) -- -- GO:0005488//GO:0046872 binding//metal ion binding -- -- -- -- Cluster-8309.9206 BF_2 17.20 0.66 1370 157137465 XP_001664001.1 158 4.2e-08 AAEL013812-PA [Aedes aegypti]>gi|108869698|gb|EAT33923.1| AAEL013812-PA [Aedes aegypti] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-8309.9227 BF_2 53.00 7.11 599 478260242 ENN80002.1 176 1.5e-10 hypothetical protein YQE_03563, partial [Dendroctonus ponderosae]>gi|546684043|gb|ERL93766.1| hypothetical protein D910_11052 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9228 BF_2 24.00 0.72 1685 642928556 XP_008195374.1 861 1.6e-89 PREDICTED: serine protease easter-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P13582 468 2.4e-45 Serine protease easter OS=Drosophila melanogaster GN=ea PE=1 SV=3 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.9233 BF_2 9.36 0.55 998 642932971 XP_008197211.1 1584 1.4e-173 PREDICTED: potassium voltage-gated channel protein Shaw [Tribolium castaneum] 645037466 XM_008219044.1 415 0 PREDICTED: Nasonia vitripennis potassium voltage-gated channel protein Shaw (LOC100120416), mRNA K05320 KCNCN potassium voltage-gated channel Shaw-related subfamily C, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05320 P17972 1472 5.5e-162 Potassium voltage-gated channel protein Shaw OS=Drosophila melanogaster GN=Shaw PE=2 SV=1 PF02214//PF00520 BTB/POZ domain//Ion transport protein GO:0055085//GO:0051260//GO:0006811 transmembrane transport//protein homooligomerization//ion transport GO:0005216 ion channel activity GO:0016020 membrane KOG3713 Voltage-gated K+ channel KCNB/KCNC Cluster-8309.9234 BF_2 5.00 0.80 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9242 BF_2 3.00 0.67 475 426366475 XP_004050283.1 604 2.8e-60 PREDICTED: polyubiquitin-B-like [Gorilla gorilla gorilla] 299116114 NM_001997.4 475 0 Homo sapiens Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (FAU), mRNA K02983 RP-S30e, RPS30 small subunit ribosomal protein S30e http://www.genome.jp/dbget-bin/www_bget?ko:K02983 P35544 365 6.0e-34 Ubiquitin-like protein FUBI OS=Homo sapiens GN=FAU PE=1 SV=1 PF00240//PF04758 Ubiquitin family//Ribosomal protein S30 GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840 intracellular//ribosome KOG0009 Ubiquitin-like/40S ribosomal S30 protein fusion Cluster-8309.9251 BF_2 1.00 1.22 308 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9252 BF_2 3.00 1.34 379 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9256 BF_2 14.00 1.26 753 161087399 ABX56859.1 195 1.2e-12 ATP synthase subunit 9 mitochondrial precursor [Litopenaeus vannamei] 338224325 HM217802.1 482 0 Scylla paramamosain ATP synthase c-subunit-like mRNA, partial sequence K02128 ATPeF0C, ATP5G, ATP9 F-type H+-transporting ATPase subunit c http://www.genome.jp/dbget-bin/www_bget?ko:K02128 Q06055 174 1.3e-11 ATP synthase F(0) complex subunit C2, mitochondrial OS=Homo sapiens GN=ATP5G2 PE=2 SV=1 PF00137 ATP synthase subunit C GO:0015992//GO:0015991 proton transport//ATP hydrolysis coupled proton transport GO:0015078 hydrogen ion transmembrane transporter activity GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain KOG3025 Mitochondrial F1F0-ATP synthase, subunit c/ATP9/proteolipid Cluster-8309.9259 BF_2 17.79 0.67 1404 642923159 XP_008193634.1 1010 7.0e-107 PREDICTED: uncharacterized protein LOC103313083 isoform X2 [Tribolium castaneum]>gi|270007587|gb|EFA04035.1| hypothetical protein TcasGA2_TC014264 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08133 Anticodon nuclease activator family GO:0050792 regulation of viral process GO:0004518 nuclease activity -- -- -- -- Cluster-8309.926 BF_2 1.00 0.41 388 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9262 BF_2 8.00 0.83 689 795270501 XP_011857247.1 1115 2.3e-119 PREDICTED: 40S ribosomal protein S8 isoform X1 [Mandrillus leucophaeus] 115553182 AK232980.1 689 0 Sus scrofa mRNA, clone:LVRM10061H09, expressed in liver K02995 RP-S8e, RPS8 small subunit ribosomal protein S8e http://www.genome.jp/dbget-bin/www_bget?ko:K02995 P62243 1101 3.9e-119 40S ribosomal protein S8 OS=Rattus norvegicus GN=Rps8 PE=1 SV=2 -- -- -- -- -- -- -- -- KOG3283 40S ribosomal protein S8 Cluster-8309.9268 BF_2 82.69 2.36 1754 270006723 EFA03171.1 916 6.9e-96 hypothetical protein TcasGA2_TC013091 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q95NT6 184 2.2e-12 G-protein coupled receptor Mth2 OS=Drosophila yakuba GN=mth2 PE=3 SV=1 PF00001//PF09398//PF00002 7 transmembrane receptor (rhodopsin family)//FOP N terminal dimerisation domain//7 transmembrane receptor (Secretin family) GO:0034453//GO:0007186 microtubule anchoring//G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021//GO:0005815 integral component of membrane//microtubule organizing center -- -- Cluster-8309.9270 BF_2 7.00 0.38 1059 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9278 BF_2 12.00 0.45 1401 390362249 XP_001190749.2 591 2.7e-58 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q4UMH6 526 3.8e-52 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.9279 BF_2 8.00 0.40 1114 780053878 XP_011669526.1 246 2.2e-18 PREDICTED: uncharacterized protein LOC100890405 [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q502K3 185 1.1e-12 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C OS=Danio rerio GN=ankrd52 PE=2 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.9281 BF_2 16.00 0.33 2298 646696832 KDR08860.1 163 1.9e-08 Tumor protein D54 [Zootermopsis nevadensis] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9284 BF_2 4.00 0.93 467 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9291 BF_2 3.00 1.50 368 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9293 BF_2 5.00 0.34 894 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9297 BF_2 1.44 0.51 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9302 BF_2 18.52 1.66 755 478254040 ENN74332.1 396 5.9e-36 hypothetical protein YQE_09302, partial [Dendroctonus ponderosae]>gi|546686146|gb|ERL95532.1| hypothetical protein D910_12794 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q5RDL3 233 1.9e-18 SH3-containing GRB2-like protein 3-interacting protein 1 OS=Pongo abelii GN=SGIP1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9305 BF_2 8.00 0.50 960 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.931 BF_2 12.15 0.98 805 478251147 ENN71623.1 971 1.3e-102 hypothetical protein YQE_11722, partial [Dendroctonus ponderosae]>gi|546685809|gb|ERL95252.1| hypothetical protein D910_12519 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9312 BF_2 14.95 4.39 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00451//PF01097 Scorpion short toxin, BmKK2//Arthropod defensin GO:0009405//GO:0006810//GO:0006952 pathogenesis//transport//defense response GO:0008200 ion channel inhibitor activity GO:0005576 extracellular region -- -- Cluster-8309.9314 BF_2 18.34 1.13 965 270005505 EFA01953.1 538 2.6e-52 hypothetical protein TcasGA2_TC007569 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9W440 369 4.2e-34 Protein THEM6 OS=Drosophila melanogaster GN=CG4666 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9320 BF_2 17.47 0.40 2112 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9321 BF_2 222.59 3.08 3311 512923481 XP_004930363.1 1887 3.3e-208 PREDICTED: protein HIRA homolog [Bombyx mori] -- -- -- -- -- K11293 HIRA, HIR1 protein HIRA/HIR1 http://www.genome.jp/dbget-bin/www_bget?ko:K11293 Q61666 1439 1.2e-157 Protein HIRA OS=Mus musculus GN=Hira PE=1 SV=3 PF00400//PF07569//PF01283 WD domain, G-beta repeat//TUP1-like enhancer of split//Ribosomal protein S26e GO:0006412//GO:0042254//GO:0006355 translation//ribosome biogenesis//regulation of transcription, DNA-templated GO:0005515//GO:0003735 protein binding//structural constituent of ribosome GO:0005634//GO:0005622//GO:0005840 nucleus//intracellular//ribosome KOG0973 Histone transcription regulator HIRA, WD repeat superfamily Cluster-8309.9322 BF_2 52.27 0.79 3046 512923481 XP_004930363.1 1820 1.8e-200 PREDICTED: protein HIRA homolog [Bombyx mori] -- -- -- -- -- K11293 HIRA, HIR1 protein HIRA/HIR1 http://www.genome.jp/dbget-bin/www_bget?ko:K11293 Q61666 1439 1.1e-157 Protein HIRA OS=Mus musculus GN=Hira PE=1 SV=3 PF00400//PF07569//PF01283 WD domain, G-beta repeat//TUP1-like enhancer of split//Ribosomal protein S26e GO:0042254//GO:0006355//GO:0006412 ribosome biogenesis//regulation of transcription, DNA-templated//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005622//GO:0005840//GO:0005634 intracellular//ribosome//nucleus KOG0973 Histone transcription regulator HIRA, WD repeat superfamily Cluster-8309.9325 BF_2 3.00 2.69 325 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9331 BF_2 10.00 0.74 856 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02724//PF04851 CDC45-like protein//Type III restriction enzyme, res subunit GO:0006270 DNA replication initiation GO:0003677//GO:0016787//GO:0005524 DNA binding//hydrolase activity//ATP binding -- -- -- -- Cluster-8309.9335 BF_2 6.00 0.47 824 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9348 BF_2 9.00 0.77 774 189233613 XP_001811691.1 484 3.8e-46 PREDICTED: uncharacterized protein LOC100141910 [Tribolium castaneum]>gi|270014658|gb|EFA11106.1| hypothetical protein TcasGA2_TC004704 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9353 BF_2 44.39 2.96 915 642928748 XP_008199766.1 265 1.1e-20 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit H-like isoform X2 [Tribolium castaneum] -- -- -- -- -- K03858 PIGH, GPI15 phosphatidylinositol glycan, class H http://www.genome.jp/dbget-bin/www_bget?ko:K03858 Q14442 151 7.6e-09 Phosphatidylinositol N-acetylglucosaminyltransferase subunit H OS=Homo sapiens GN=PIGH PE=1 SV=1 PF10181 GPI-GlcNAc transferase complex, PIG-H component -- -- GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity -- -- -- -- Cluster-8309.9362 BF_2 17.46 0.74 1268 270016741 EFA13187.1 156 6.7e-08 hypothetical protein TcasGA2_TC006862 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9368 BF_2 45.41 18.19 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.937 BF_2 3.00 0.70 466 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9370 BF_2 22.03 0.33 3093 270003283 EEZ99730.1 288 8.1e-23 hypothetical protein TcasGA2_TC002499 [Tribolium castaneum] -- -- -- -- -- K17233 DUOXA1 dual oxidase maturation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K17233 -- -- -- -- PF10204 Dual oxidase maturation factor GO:0015031 protein transport -- -- GO:0016021//GO:0005789 integral component of membrane//endoplasmic reticulum membrane -- -- Cluster-8309.9373 BF_2 94.31 2.44 1902 641664992 XP_008183213.1 994 6.8e-105 PREDICTED: zinc finger protein 271-like [Acyrthosiphon pisum] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9UJW8 923 4.8e-98 Zinc finger protein 180 OS=Homo sapiens GN=ZNF180 PE=1 SV=2 PF07975//PF00096//PF13465//PF07776//PF16622//PF13912 TFIIH C1-like domain//Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//zinc-finger C2H2-type//C2H2-type zinc finger GO:0006281 DNA repair GO:0008270//GO:0046872 zinc ion binding//metal ion binding GO:0005634 nucleus -- -- Cluster-8309.9383 BF_2 54.00 1.94 1451 675390327 KFM83224.1 393 2.5e-35 Zinc finger protein 850, partial [Stegodyphus mimosarum] -- -- -- -- -- K09230 SCAN SCAN domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09230 B4DXR9 358 1.2e-32 Zinc finger protein 732 OS=Homo sapiens GN=ZNF732 PE=2 SV=1 PF00096//PF13465//PF07776//PF04810//PF13912 Zinc finger, C2H2 type//Zinc-finger double domain//Zinc-finger associated domain (zf-AD)//Sec23/Sec24 zinc finger//C2H2-type zinc finger GO:0006888//GO:0006886 ER to Golgi vesicle-mediated transport//intracellular protein transport GO:0046872//GO:0008270 metal ion binding//zinc ion binding GO:0030127//GO:0005634 COPII vesicle coat//nucleus -- -- Cluster-8309.9389 BF_2 1.00 0.64 348 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9390 BF_2 237.00 13.15 1041 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P05585 125 8.9e-06 Ovomucoid (Fragment) OS=Bonasa umbellus PE=1 SV=1 PF00050//PF07648 Kazal-type serine protease inhibitor domain//Kazal-type serine protease inhibitor domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9397 BF_2 2.04 0.50 457 642922794 XP_008193328.1 154 4.1e-08 PREDICTED: inter-alpha-trypsin inhibitor heavy chain H4-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9398 BF_2 22.90 0.64 1792 91087699 XP_974256.1 900 5.1e-94 PREDICTED: alpha-(1,3)-fucosyltransferase C [Tribolium castaneum]>gi|270009408|gb|EFA05856.1| hypothetical protein TcasGA2_TC008651 [Tribolium castaneum] -- -- -- -- -- K14464 FUT-1, FucTC alpha-1,3-fucosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K14464 P83088 579 3.5e-58 Alpha-(1,3)-fucosyltransferase C OS=Drosophila melanogaster GN=FucTC PE=2 SV=4 PF00852 Glycosyltransferase family 10 (fucosyltransferase) C-term GO:0006486 protein glycosylation GO:0016740//GO:0008417 transferase activity//fucosyltransferase activity GO:0016020 membrane KOG2619 Fucosyltransferase Cluster-8309.9399 BF_2 16.00 0.96 987 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9400 BF_2 9.00 0.35 1360 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9404 BF_2 117.00 3.12 1855 642928547 XP_008195370.1 1453 3.9e-158 PREDICTED: protein Wnt-1-like [Tribolium castaneum] -- -- -- -- -- K00408 WNT4 wingless-type MMTV integration site family, member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K00408 P56705 765 9.7e-80 Protein Wnt-4 OS=Homo sapiens GN=WNT4 PE=1 SV=4 PF00110 wnt family GO:0016055//GO:0007275//GO:0007165 Wnt signaling pathway//multicellular organismal development//signal transduction GO:0005102 receptor binding GO:0005576 extracellular region -- -- Cluster-8309.9406 BF_2 47.53 0.48 4459 546670638 ERL83322.1 788 1.2e-80 hypothetical protein D910_00217 [Dendroctonus ponderosae]>gi|546672557|gb|ERL84374.1| hypothetical protein D910_01802 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8C6L5 135 2.6e-06 Cyclic GMP-AMP synthase OS=Mus musculus GN=Mb21d1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9418 BF_2 15.57 0.51 1561 270002318 EEZ98765.1 614 6.4e-61 hypothetical protein TcasGA2_TC001329 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96EX3 187 8.6e-13 WD repeat-containing protein 34 OS=Homo sapiens GN=WDR34 PE=1 SV=2 PF02497//PF12515//PF15184//PF00400 Arterivirus glycoprotein//Ca2+-ATPase N terminal autoinhibitory domain//Mitochondrial import receptor subunit TOM6 homolog//WD domain, G-beta repeat -- -- GO:0005516//GO:0005515 calmodulin binding//protein binding GO:0005742//GO:0019031 mitochondrial outer membrane translocase complex//viral envelope -- -- Cluster-8309.9426 BF_2 1.00 2.01 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9427 BF_2 15.00 3.92 447 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.943 BF_2 7.00 0.35 1128 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9432 BF_2 5.00 0.80 548 91084875 XP_968453.1 180 4.8e-11 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270008975|gb|EFA05423.1| hypothetical protein TcasGA2_TC015599 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 128 2.1e-06 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 -- -- GO:0008152 metabolic process -- -- -- -- -- -- Cluster-8309.9434 BF_2 43.00 1.24 1738 91091346 XP_972193.1 629 1.3e-62 PREDICTED: solute carrier family 25 member 35-like [Tribolium castaneum] -- -- -- -- -- K15117 SLC25A34_35, OAC1 solute carrier family 25, member 34/35 http://www.genome.jp/dbget-bin/www_bget?ko:K15117 A3KPP4 500 4.9e-49 Solute carrier family 25 member 35 OS=Danio rerio GN=slc25a35 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG0755 Mitochondrial oxaloacetate carrier protein Cluster-8309.9437 BF_2 60.00 1.22 2349 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9448 BF_2 18.00 1.22 906 91086029 XP_973201.1 551 7.5e-54 PREDICTED: origin recognition complex subunit 6 [Tribolium castaneum]>gi|270009926|gb|EFA06374.1| hypothetical protein TcasGA2_TC009250 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9Y1B2 300 3.9e-26 Origin recognition complex subunit 6 OS=Drosophila melanogaster GN=Orc6 PE=1 SV=2 PF05460//PF00382//PF05615//PF00420 Origin recognition complex subunit 6 (ORC6)//Transcription factor TFIIB repeat//Tho complex subunit 7//NADH-ubiquinone/plastoquinone oxidoreductase chain 4L GO:0042773//GO:0006397//GO:0055114//GO:0006260 ATP synthesis coupled electron transport//mRNA processing//oxidation-reduction process//DNA replication GO:0016651//GO:0003677//GO:0017025 oxidoreductase activity, acting on NAD(P)H//DNA binding//TBP-class protein binding GO:0005664//GO:0000445 nuclear origin of replication recognition complex//THO complex part of transcription export complex KOG4557 Origin recognition complex, subunit 6 Cluster-8309.9450 BF_2 20.34 0.39 2441 642934658 XP_008197755.1 2041 3.4e-226 PREDICTED: partitioning defective 3 homolog isoform X2 [Tribolium castaneum] 766917723 XM_011496118.1 51 4.91771e-15 PREDICTED: Ceratosolen solmsi marchali partitioning defective 3 homolog (LOC105359501), mRNA K04237 PARD3 partitioning defective protein 3 http://www.genome.jp/dbget-bin/www_bget?ko:K04237 Q8TEW0 503 3.1e-49 Partitioning defective 3 homolog OS=Homo sapiens GN=PARD3 PE=1 SV=2 PF00595//PF13180 PDZ domain (Also known as DHR or GLGF)//PDZ domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9451 BF_2 24.87 3.07 626 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9455 BF_2 86.00 3.82 1229 478250862 ENN71351.1 728 3.1e-74 hypothetical protein YQE_11966, partial [Dendroctonus ponderosae]>gi|546685629|gb|ERL95105.1| hypothetical protein D910_12375 [Dendroctonus ponderosae] -- -- -- -- -- K19404 LIPH_I phosphatidic acid-selective phospholipase A1 http://www.genome.jp/dbget-bin/www_bget?ko:K19404 Q6PA23 349 1.1e-31 Lipase member H-A OS=Xenopus laevis GN=liph-a PE=2 SV=1 PF01764 Lipase (class 3) GO:0006629 lipid metabolic process -- -- -- -- -- -- Cluster-8309.9460 BF_2 11.00 0.42 1382 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00643 B-box zinc finger -- -- GO:0008270 zinc ion binding GO:0005622 intracellular -- -- Cluster-8309.9467 BF_2 10.00 0.67 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.947 BF_2 1.00 0.61 351 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9473 BF_2 2.87 2.23 334 642917260 XP_008199225.1 145 3.3e-07 PREDICTED: uncharacterized protein LOC103314591 isoform X1 [Tribolium castaneum]>gi|270004754|gb|EFA01202.1| hypothetical protein TcasGA2_TC010529 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9478 BF_2 1.00 3.32 266 642925814 XP_970128.3 221 4.1e-16 PREDICTED: dehydrogenase/reductase SDR family member 11-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 143 1.8e-08 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.9481 BF_2 8.46 1.69 497 642921320 XP_008192819.1 381 2.1e-34 PREDICTED: uncharacterized protein LOC103312853 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17102 EHF ETS homologous factor http://www.genome.jp/dbget-bin/www_bget?ko:K17102 A1YG61 263 4.2e-22 ETS homologous factor OS=Pan paniscus GN=EHF PE=3 SV=1 PF00178 Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3804 Transcription factor NERF and related proteins, contain ETS domain Cluster-8309.9483 BF_2 28.11 0.58 2319 642914671 XP_008190309.1 831 6.6e-86 PREDICTED: uncharacterized protein LOC662983 isoform X3 [Tribolium castaneum] -- -- -- -- -- K08190 SLC16A14 MFS transporter, MCP family, solute carrier family 16 (monocarboxylic acid transporters), member 14 http://www.genome.jp/dbget-bin/www_bget?ko:K08190 Q7RTX9 401 2.0e-37 Monocarboxylate transporter 14 OS=Homo sapiens GN=SLC16A14 PE=2 SV=1 PF00083//PF07690 Sugar (and other) transporter//Major Facilitator Superfamily GO:0055085 transmembrane transport GO:0022857 transmembrane transporter activity GO:0016021 integral component of membrane -- -- Cluster-8309.9496 BF_2 29.00 0.68 2071 189237068 XP_001809825.1 354 1.2e-30 PREDICTED: cuticle protein 7-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P11734 267 6.1e-22 Cuticle protein 8 OS=Locusta migratoria PE=1 SV=1 PF03870//PF00379 RNA polymerase Rpb8//Insect cuticle protein GO:0006351 transcription, DNA-templated GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-8309.9504 BF_2 7.00 0.71 702 91080607 XP_967476.1 164 4.4e-09 PREDICTED: zonadhesin [Tribolium castaneum]>gi|270005833|gb|EFA02281.1| hypothetical protein TcasGA2_TC007945 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- O46202 128 2.7e-06 Accessory gland protein Acp62F OS=Drosophila melanogaster GN=Acp62F PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9506 BF_2 31.05 1.55 1123 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.951 BF_2 50.00 3.34 913 91086899 XP_970867.1 637 8.1e-64 PREDICTED: ubiquitin-conjugating enzyme E2 T [Tribolium castaneum]>gi|270009677|gb|EFA06125.1| hypothetical protein TcasGA2_TC008968 [Tribolium castaneum] -- -- -- -- -- K13960 UBE2T, HSPC150 ubiquitin-conjugating enzyme E2 T http://www.genome.jp/dbget-bin/www_bget?ko:K13960 Q9NPD8 452 9.4e-44 Ubiquitin-conjugating enzyme E2 T OS=Homo sapiens GN=UBE2T PE=1 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005524//GO:0016881//GO:0005515 ATP binding//acid-amino acid ligase activity//protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8309.9511 BF_2 15.00 0.49 1568 91084487 XP_971744.1 594 1.3e-58 PREDICTED: equilibrative nucleoside transporter 3 [Tribolium castaneum]>gi|270008874|gb|EFA05322.1| hypothetical protein TcasGA2_TC015480 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- A1A4N1 349 1.4e-31 Equilibrative nucleoside transporter 3 OS=Bos taurus GN=SLC29A3 PE=2 SV=1 PF01733//PF00573 Nucleoside transporter//Ribosomal protein L4/L1 family GO:0015858//GO:0006810//GO:0006412//GO:0042254 nucleoside transport//transport//translation//ribosome biogenesis GO:0003735//GO:0005337 structural constituent of ribosome//nucleoside transmembrane transporter activity GO:0016021//GO:0005840 integral component of membrane//ribosome -- -- Cluster-8309.9513 BF_2 8.30 0.39 1189 668453032 KFB41786.1 893 2.2e-93 AGAP003352-PB-like protein [Anopheles sinensis] -- -- -- -- -- K17286 STOM erythrocyte band 7 integral membrane protein http://www.genome.jp/dbget-bin/www_bget?ko:K17286 Q9VZA4 780 1.1e-81 Band 7 protein CG42540 OS=Drosophila melanogaster GN=CG42540 PE=2 SV=2 -- -- -- -- -- -- -- -- KOG2621 Prohibitins and stomatins of the PID superfamily Cluster-8309.9514 BF_2 10.00 0.55 1046 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9520 BF_2 18.00 0.38 2266 546684810 ERL94392.1 1251 1.3e-134 hypothetical protein D910_11671 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q09225 460 2.8e-44 Nose resistant to fluoxetine protein 6 OS=Caenorhabditis elegans GN=nrf-6 PE=1 SV=3 PF10220//PF01757//PF06736 Uncharacterized conserved protein (DUF2146)//Acyltransferase family//Protein of unknown function (DUF1211) GO:0006813//GO:0000184 potassium ion transport//nuclear-transcribed mRNA catabolic process, nonsense-mediated decay GO:0005267//GO:0016747 potassium channel activity//transferase activity, transferring acyl groups other than amino-acyl groups -- -- -- -- Cluster-8309.9528 BF_2 6.68 0.46 898 728418700 AIY68378.1 416 3.4e-38 putative alpha-esterase [Leptinotarsa decemlineata] -- -- -- -- -- K15743 CES3_5 carboxylesterase 3/5 http://www.genome.jp/dbget-bin/www_bget?ko:K15743 P35502 248 4.2e-20 Esterase FE4 OS=Myzus persicae PE=1 SV=1 PF06973//PF00326//PF07859 Domain of unknown function (DUF1297)//Prolyl oligopeptidase family//alpha/beta hydrolase fold GO:0006508//GO:0008152//GO:0006188 proteolysis//metabolic process//IMP biosynthetic process GO:0000287//GO:0008236//GO:0005524//GO:0016787//GO:0016879 magnesium ion binding//serine-type peptidase activity//ATP binding//hydrolase activity//ligase activity, forming carbon-nitrogen bonds -- -- -- -- Cluster-8309.953 BF_2 11.82 0.42 1477 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q3ZCU0 132 2.0e-06 Putative uncharacterized protein FLJ37770 OS=Homo sapiens PE=5 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8309.9533 BF_2 7.00 0.39 1042 391331373 XP_003740121.1 1143 2.0e-122 PREDICTED: amine oxidase [flavin-containing]-like [Metaseiulus occidentalis] -- -- -- -- -- K00274 MAO, aofH monoamine oxidase http://www.genome.jp/dbget-bin/www_bget?ko:K00274 P58027 845 2.9e-89 Amine oxidase [flavin-containing] A OS=Canis familiaris GN=MAOA PE=2 SV=1 PF01494//PF07992//PF01593//PF02254//PF12831//PF06100//PF05834//PF01266//PF01134//PF00070 FAD binding domain//Pyridine nucleotide-disulphide oxidoreductase//Flavin containing amine oxidoreductase//TrkA-N domain//FAD dependent oxidoreductase//MCRA family//Lycopene cyclase protein//FAD dependent oxidoreductase//Glucose inhibited division protein A//Pyridine nucleotide-disulphide oxidoreductase GO:0008033//GO:0055114//GO:0006631//GO:0016117//GO:0006813 tRNA processing//oxidation-reduction process//fatty acid metabolic process//carotenoid biosynthetic process//potassium ion transport GO:0050660//GO:0016491//GO:0050151//GO:0071949//GO:0016705 flavin adenine dinucleotide binding//oxidoreductase activity//oleate hydratase activity//FAD binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- KOG0029 Amine oxidase Cluster-8309.9535 BF_2 55.15 4.22 834 546683280 ERL93112.1 576 8.7e-57 hypothetical protein D910_10414 [Dendroctonus ponderosae] -- -- -- -- -- K08967 mtnD, mtnZ, ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase http://www.genome.jp/dbget-bin/www_bget?ko:K08967 E0W481 447 3.3e-43 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase OS=Pediculus humanus subsp. corporis GN=Phum_PHUM616140 PE=3 SV=1 PF03079//PF02311 ARD/ARD' family//AraC-like ligand binding domain GO:0055114//GO:0006355 oxidation-reduction process//regulation of transcription, DNA-templated GO:0010309 acireductone dioxygenase [iron(II)-requiring] activity -- -- KOG2107 Uncharacterized conserved protein, contains double-stranded beta-helix domain Cluster-8309.9536 BF_2 80.76 2.06 1925 478255950 ENN76151.1 285 1.1e-22 hypothetical protein YQE_07322, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q8NCT1 194 1.6e-13 Arrestin domain-containing protein 4 OS=Homo sapiens GN=ARRDC4 PE=2 SV=3 -- -- -- -- -- -- -- -- KOG3780 Thioredoxin binding protein TBP-2/VDUP1 Cluster-8309.9542 BF_2 2.55 0.32 623 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9543 BF_2 4.42 0.36 796 642912148 XP_008200826.1 322 2.4e-27 PREDICTED: nose resistant to fluoxetine protein 6-like [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9546 BF_2 10.98 0.40 1443 795094282 XP_011879929.1 643 2.6e-64 PREDICTED: uncharacterized protein LOC105568681 [Vollenhovia emeryi] 817183960 XM_012423831.1 174 1.21268e-83 PREDICTED: Orussus abietinus uncharacterized LOC105699098 (LOC105699098), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9549 BF_2 3.00 0.32 680 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.955 BF_2 33.64 0.67 2402 642919385 XP_008191851.1 1996 5.5e-221 PREDICTED: synaptotagmin-5 isoform X2 [Tribolium castaneum] 768449804 XM_011568704.1 71 3.68745e-26 PREDICTED: Plutella xylostella synaptotagmin-5-like (LOC105396697), partial mRNA -- -- -- -- Q9R0N8 502 4.0e-49 Synaptotagmin-6 OS=Mus musculus GN=Syt6 PE=1 SV=2 PF00168 C2 domain -- -- GO:0005515 protein binding -- -- KOG1028 Ca2+-dependent phospholipid-binding protein Synaptotagmin, required for synaptic vesicle and secretory granule exocytosis Cluster-8309.9558 BF_2 21.45 0.38 2662 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9564 BF_2 26.23 0.84 1600 642912288 XP_008200636.1 687 2.3e-69 PREDICTED: venom protease-like [Tribolium castaneum]>gi|270002898|gb|EEZ99345.1| serine protease P56 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P05049 537 2.3e-53 Serine protease snake OS=Drosophila melanogaster GN=snk PE=1 SV=2 PF08449//PF00089 UAA transporter family//Trypsin GO:0006508//GO:0055085 proteolysis//transmembrane transport GO:0016787//GO:0004252 hydrolase activity//serine-type endopeptidase activity -- -- -- -- Cluster-8309.9573 BF_2 31.00 0.67 2209 332375106 AEE62694.1 744 7.7e-76 unknown [Dendroctonus ponderosae] 332375105 BT127732.1 396 0 Dendroctonus ponderosae clone DPO119_L10 unknown mRNA -- -- -- -- B0BN95 157 3.7e-09 Putative nuclease HARBI1 OS=Rattus norvegicus GN=Harbi1 PE=2 SV=1 PF04827 Plant transposon protein -- -- GO:0016788 hydrolase activity, acting on ester bonds -- -- -- -- Cluster-8309.9574 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08752 Coatomer gamma subunit appendage platform subdomain GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005198 structural molecule activity GO:0030126 COPI vesicle coat -- -- Cluster-8309.9586 BF_2 57.00 0.36 6988 546671289 ERL83664.1 3798 0.0e+00 hypothetical protein D910_00834 [Dendroctonus ponderosae]>gi|546671392|gb|ERL83721.1| hypothetical protein D910_00934 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00424//PF01520 REV protein (anti-repression trans-activator protein)//N-acetylmuramoyl-L-alanine amidase GO:0006355//GO:0009252//GO:0006807//GO:0009253 regulation of transcription, DNA-templated//peptidoglycan biosynthetic process//nitrogen compound metabolic process//peptidoglycan catabolic process GO:0008745//GO:0003700 N-acetylmuramoyl-L-alanine amidase activity//transcription factor activity, sequence-specific DNA binding GO:0042025//GO:0005667 host cell nucleus//transcription factor complex -- -- Cluster-8309.9593 BF_2 36.05 0.49 3377 642921163 XP_008192741.1 2293 2.8e-255 PREDICTED: sip1/TFIP11 interacting protein isoform X1 [Tribolium castaneum]>gi|270006305|gb|EFA02753.1| hypothetical protein TcasGA2_TC008486 [Tribolium castaneum] -- -- -- -- -- K13103 TFIP11 tuftelin-interacting protein 11 http://www.genome.jp/dbget-bin/www_bget?ko:K13103 Q0IIX9 1225 8.1e-133 Tuftelin-interacting protein 11 OS=Xenopus tropicalis GN=tfip11 PE=2 SV=2 PF01585//PF07842 G-patch domain//GC-rich sequence DNA-binding factor-like protein GO:0008380//GO:0006397//GO:0006355 RNA splicing//mRNA processing//regulation of transcription, DNA-templated GO:0003676//GO:0003677 nucleic acid binding//DNA binding GO:0005681//GO:0005634 spliceosomal complex//nucleus KOG2184 Tuftelin-interacting protein TIP39, contains G-patch domain Cluster-8309.9596 BF_2 3.00 0.59 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9597 BF_2 33.36 0.80 2032 642938979 XP_008200100.1 558 2.6e-54 PREDICTED: diuretic hormone 37 like protein isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P56619 194 1.7e-13 Diuretic hormone 2 OS=Tenebrio molitor PE=1 SV=1 PF00473 Corticotropin-releasing factor family GO:0007165 signal transduction GO:0005179 hormone activity GO:0005576 extracellular region -- -- Cluster-8309.9602 BF_2 10.00 0.36 1435 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9613 BF_2 3.00 0.75 455 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9631 BF_2 40.92 0.37 4910 91092640 XP_969145.1 1718 2.0e-188 PREDICTED: lysine-specific demethylase 7B [Tribolium castaneum]>gi|270014836|gb|EFA11284.1| hypothetical protein TcasGA2_TC010820 [Tribolium castaneum] -- -- -- -- -- K11445 KDM7A, JHDM1D lysine-specific demethylase 7A http://www.genome.jp/dbget-bin/www_bget?ko:K11445 Q5RHD1 805 5.9e-84 Lysine-specific demethylase 7A OS=Danio rerio GN=kdm7a PE=2 SV=2 PF00628 PHD-finger -- -- GO:0005515 protein binding -- -- KOG1633 F-box protein JEMMA and related proteins with JmjC, PHD, F-box and LRR domains Cluster-8309.9635 BF_2 57.00 1.21 2254 167466209 NP_001034503.2 1710 7.6e-188 fork head [Tribolium castaneum]>gi|270008139|gb|EFA04587.1| fork head [Tribolium castaneum] 462360555 APGK01029353.1 157 5.38951e-74 Dendroctonus ponderosae Seq01029363, whole genome shotgun sequence K08035 FOXA2, HNF3B forkhead box protein A2, hepatocyte nuclear factor 3-beta http://www.genome.jp/dbget-bin/www_bget?ko:K08035 P14734 975 5.3e-104 Protein fork head OS=Drosophila melanogaster GN=fkh PE=1 SV=1 PF00250//PF08430 Forkhead domain//Forkhead N-terminal region GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0019904//GO:0008134//GO:0003700 sequence-specific DNA binding//protein domain specific binding//transcription factor binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3563 Forkhead/HNF-3-related transcription factor Cluster-8309.9637 BF_2 6.00 0.33 1059 795012426 XP_011878089.1 228 2.5e-16 PREDICTED: uncharacterized protein LOC105567651, partial [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9646 BF_2 15.81 0.73 1193 443728181 ELU14642.1 234 5.7e-17 hypothetical protein CAPTEDRAFT_135345 [Capitella teleta] -- -- -- -- -- K09229 ZKSCAN KRAB and SCAN domains-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09229 P18714 224 3.4e-17 Gastrula zinc finger protein xFG20-1 OS=Xenopus laevis PE=3 SV=2 PF00096//PF13465//PF04828//PF02892 Zinc finger, C2H2 type//Zinc-finger double domain//Glutathione-dependent formaldehyde-activating enzyme//BED zinc finger GO:0008152 metabolic process GO:0046872//GO:0016846//GO:0003677 metal ion binding//carbon-sulfur lyase activity//DNA binding -- -- -- -- Cluster-8309.965 BF_2 3.00 0.58 504 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9660 BF_2 56.00 2.52 1216 307212038 EFN87922.1 251 6.2e-19 hypothetical protein EAI_08475, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9669 BF_2 1.00 0.84 329 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9675 BF_2 54.96 0.52 4745 189240461 XP_973773.2 5639 0.0e+00 PREDICTED: intraflagellar transport protein 140 homolog [Tribolium castaneum]>gi|270012537|gb|EFA08985.1| hypothetical protein TcasGA2_TC006692 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96RY7 2485 8.9e-279 Intraflagellar transport protein 140 homolog OS=Homo sapiens GN=IFT140 PE=1 SV=1 PF00515//PF13374//PF13181//PF13176//PF00637//PF04053//PF13414 Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Region in Clathrin and VPS//Coatomer WD associated region//TPR repeat GO:0006886//GO:0016192 intracellular protein transport//vesicle-mediated transport GO:0005515//GO:0005198 protein binding//structural molecule activity GO:0030117 membrane coat KOG3617 WD40 and TPR repeat-containing protein Cluster-8309.9681 BF_2 1.00 1.17 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9687 BF_2 38.30 1.48 1366 642912341 XP_008199603.1 1414 9.7e-154 PREDICTED: DNA polymerase delta catalytic subunit [Tribolium castaneum]>gi|270002921|gb|EEZ99368.1| DNA polymerase delta [Tribolium castaneum] 324120767 AB598735.1 66 1.24793e-23 Ctenocephalides felis DPD1 mRNA for DNA polymerase delta catalytic subunit, partial cds, isolate: 53 K02327 POLD1 DNA polymerase delta subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02327 P54358 975 3.2e-104 DNA polymerase delta catalytic subunit OS=Drosophila melanogaster GN=DNApol-delta PE=2 SV=2 PF03104 DNA polymerase family B, exonuclease domain GO:0006260 DNA replication GO:0003887//GO:0000166//GO:0003677//GO:0008408 DNA-directed DNA polymerase activity//nucleotide binding//DNA binding//3'-5' exonuclease activity GO:0042575 DNA polymerase complex KOG0969 DNA polymerase delta, catalytic subunit Cluster-8309.9688 BF_2 6.88 1.12 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9696 BF_2 31.58 0.47 3106 749789601 XP_011148114.1 436 5.6e-40 PREDICTED: histone-lysine N-methyltransferase SETMAR-like [Harpegnathos saltator] 168488035 EU365789.1 205 1.54647e-100 Drosophila yakuba strain CY27 tan gene, 5' upstream region -- -- -- -- -- -- -- -- PF00658//PF04545 Poly-adenylate binding protein, unique domain//Sigma-70, region 4 GO:0006355//GO:0006352 regulation of transcription, DNA-templated//DNA-templated transcription, initiation GO:0003723//GO:0003677//GO:0016987//GO:0003700 RNA binding//DNA binding//sigma factor activity//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.9697 BF_2 63.89 3.39 1076 478255317 ENN75543.1 159 2.6e-08 hypothetical protein YQE_07886, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9706 BF_2 1.00 6.50 245 669214688 CDW61246.1 164 1.5e-09 hypothetical protein TTRE_0000969201, partial [Trichuris trichiura] 672605233 CP006704.1 230 1.3537e-115 Comamonas testosteroni TK102, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9708 BF_2 1.00 0.44 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9712 BF_2 7.86 0.51 938 641669667 XP_008184906.1 223 8.4e-16 PREDICTED: uncharacterized protein LOC100574215 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9713 BF_2 28.27 0.32 3971 641661038 XP_008181718.1 1176 1.1e-125 PREDICTED: uncharacterized protein LOC103309021 [Acyrthosiphon pisum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF08144//PF04827//PF01609 CPL (NUC119) domain//Plant transposon protein//Transposase DDE domain GO:0006313 transposition, DNA-mediated GO:0004803//GO:0003723//GO:0016788//GO:0003677 transposase activity//RNA binding//hydrolase activity, acting on ester bonds//DNA binding -- -- -- -- Cluster-8309.972 BF_2 12.88 0.43 1529 815821967 XP_012232242.1 234 7.3e-17 PREDICTED: tyrosine-protein kinase hopscotch [Linepithema humile] -- -- -- -- -- K08886 TNK2, ACK1 activated CDC42 kinase 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08886 Q5U2X5 217 2.8e-16 Activated CDC42 kinase 1 OS=Rattus norvegicus GN=Tnk2 PE=2 SV=1 PF00069//PF07714//PF08923 Protein kinase domain//Protein tyrosine kinase//Mitogen-activated protein kinase kinase 1 interacting GO:0032006//GO:0006468 regulation of TOR signaling//protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8309.9726 BF_2 1.00 0.33 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9735 BF_2 9.09 0.55 973 91079010 XP_974804.1 425 3.3e-39 PREDICTED: putative inositol monophosphatase 3 [Tribolium castaneum]>gi|270004173|gb|EFA00621.1| hypothetical protein TcasGA2_TC003497 [Tribolium castaneum] -- -- -- -- -- K15759 IMPAD1, IMPA3 inositol monophosphatase 3 http://www.genome.jp/dbget-bin/www_bget?ko:K15759 Q9VYF2 297 9.4e-26 Putative inositol monophosphatase 3 OS=Drosophila melanogaster GN=CG15743 PE=2 SV=1 PF00459 Inositol monophosphatase family GO:0046854 phosphatidylinositol phosphorylation -- -- -- -- KOG3853 Inositol monophosphatase Cluster-8309.9736 BF_2 69.20 2.12 1654 167444222 ABZ80672.1 601 2.2e-59 peptidoglycan recognition protein 1 [Sitophilus zeamais] -- -- -- -- -- K01446 E3.5.1.28 N-acetylmuramoyl-L-alanine amidase http://www.genome.jp/dbget-bin/www_bget?ko:K01446 Q8INK6 463 9.1e-45 Peptidoglycan-recognition protein LB OS=Drosophila melanogaster GN=PGRP-LB PE=1 SV=1 PF01510 N-acetylmuramoyl-L-alanine amidase GO:0009252//GO:0009253//GO:0006807 peptidoglycan biosynthetic process//peptidoglycan catabolic process//nitrogen compound metabolic process GO:0008745 N-acetylmuramoyl-L-alanine amidase activity -- -- -- -- Cluster-8309.9737 BF_2 2.00 0.77 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9744 BF_2 55.00 2.20 1332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08654//PF04136//PF04513 DASH complex subunit Dad2//Sec34-like family//Baculovirus polyhedron envelope protein, PEP, C terminus GO:0007067//GO:0006886 mitotic nuclear division//intracellular protein transport GO:0005198 structural molecule activity GO:0042729//GO:0016020//GO:0005801//GO:0019031//GO:0019028//GO:0072686 DASH complex//membrane//cis-Golgi network//viral envelope//viral capsid//mitotic spindle -- -- Cluster-8309.9749 BF_2 5.00 0.52 687 780705582 XP_011703132.1 569 4.7e-56 PREDICTED: UPF0585 protein C16orf13 homolog A isoform X2 [Wasmannia auropunctata] -- -- -- -- -- -- -- -- -- Q9VLF6 500 1.9e-49 UPF0585 protein CG18661 OS=Drosophila melanogaster GN=CG18661 PE=2 SV=2 PF08241 Methyltransferase domain GO:0008152 metabolic process GO:0008168 methyltransferase activity -- -- -- -- Cluster-8309.9750 BF_2 12.66 0.67 1078 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9756 BF_2 35.89 0.69 2474 795019186 XP_011859494.1 201 7.9e-13 PREDICTED: uncharacterized protein LOC105556985 [Vollenhovia emeryi] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03184 DDE superfamily endonuclease -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.9762 BF_2 36.00 2.98 793 381234574 AFF76545.1 799 1.2e-82 cytochrome c oxidase subunit II (mitochondrion) [Homo sapiens] 893712393 KT250561.1 792 0 Homo sapiens haplogroup H5a6 mitochondrion, complete genome K02261 COX2 cytochrome c oxidase subunit 2 http://www.genome.jp/dbget-bin/www_bget?ko:K02261 P00403 798 6.2e-84 Cytochrome c oxidase subunit 2 OS=Homo sapiens GN=MT-CO2 PE=1 SV=1 PF02790//PF05434 Cytochrome C oxidase subunit II, transmembrane domain//TMEM9 GO:0022900 electron transport chain -- -- GO:0016021 integral component of membrane KOG4767 Cytochrome c oxidase, subunit II, and related proteins Cluster-8309.9774 BF_2 8.00 0.31 1363 780074942 XP_011672046.1 160 2.5e-08 PREDICTED: ankyrin repeat domain-containing protein 17-like [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- Q8C8R3 140 2.1e-07 Ankyrin-2 OS=Mus musculus GN=Ank2 PE=1 SV=2 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.9776 BF_2 3.32 0.33 703 607355113 EZA49708.1 283 6.9e-23 hypothetical protein X777_11794 [Cerapachys biroi] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9778 BF_2 50.00 3.33 915 311739209 ADQ01809.1 1201 3.2e-129 opsin protein [Uca pugilator] 311739208 HM765425.1 405 0 Celuca pugilator opsin protein (Rh1) mRNA, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 1183 1.6e-128 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.9779 BF_2 16.00 2.64 541 253464615 ACT31580.1 503 1.7e-48 opsin 1 [Uca vomeris] 829042 D50583.1 253 5.30188e-128 Hemigrapsus sanguineus mRNA for opsin BcRh1, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 516 2.1e-51 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane -- -- Cluster-8309.9780 BF_2 1.00 0.35 407 311739209 ADQ01809.1 419 6.8e-39 opsin protein [Uca pugilator] 829042 D50583.1 228 3.08925e-114 Hemigrapsus sanguineus mRNA for opsin BcRh1, complete cds K04255 OPN4, Rh2_7 r-opsin http://www.genome.jp/dbget-bin/www_bget?ko:K04255 Q25157 425 5.7e-41 Compound eye opsin BCRH1 OS=Hemigrapsus sanguineus PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8309.9789 BF_2 2.00 0.33 540 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9791 BF_2 107.81 0.69 6797 642918714 XP_008191551.1 2723 7.9e-305 PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|642918716|ref|XP_008191552.1| PREDICTED: phospholipase D2 isoform X2 [Tribolium castaneum]>gi|270005665|gb|EFA02113.1| hypothetical protein TcasGA2_TC007759 [Tribolium castaneum] -- -- -- -- -- K01115 PLD1_2 phospholipase D1/2 http://www.genome.jp/dbget-bin/www_bget?ko:K01115 Q13393 1322 9.2e-144 Phospholipase D1 OS=Homo sapiens GN=PLD1 PE=1 SV=1 PF00614//PF00787//PF02399 Phospholipase D Active site motif//PX domain//Origin of replication binding protein GO:0006260//GO:0007154//GO:0008152 DNA replication//cell communication//metabolic process GO:0003688//GO:0003824//GO:0005524//GO:0035091 DNA replication origin binding//catalytic activity//ATP binding//phosphatidylinositol binding GO:0046809 replication compartment KOG1329 Phospholipase D1 Cluster-8309.9793 BF_2 3.00 0.55 514 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9797 BF_2 51.12 2.69 1082 91082291 XP_973881.1 1084 1.4e-115 PREDICTED: probable tRNA pseudouridine synthase 2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q5XGG2 494 1.5e-48 Probable tRNA pseudouridine synthase 2 OS=Xenopus tropicalis GN=trub2 PE=2 SV=1 PF01509 TruB family pseudouridylate synthase (N terminal domain) GO:0006396 RNA processing -- -- -- -- KOG2559 Predicted pseudouridine synthase Cluster-8309.98 BF_2 2.00 0.44 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9809 BF_2 85.00 4.62 1056 91078008 XP_969762.1 322 3.2e-27 PREDICTED: fatty acid-binding protein, liver [Tribolium castaneum]>gi|270002862|gb|EEZ99309.1| cellular FABP-like protein [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9812 BF_2 238.67 4.06 2747 642921884 XP_967663.2 2711 7.8e-304 PREDICTED: conserved oligomeric Golgi complex subunit 5 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VJD3 1057 2.0e-113 Conserved oligomeric Golgi complex subunit 5 OS=Drosophila melanogaster GN=fws PE=2 SV=1 PF10392//PF14144 Golgi transport complex subunit 5//Seed dormancy control GO:0006351//GO:0006891 transcription, DNA-templated//intra-Golgi vesicle-mediated transport GO:0043565 sequence-specific DNA binding GO:0017119 Golgi transport complex KOG2211 Predicted Golgi transport complex 1 protein Cluster-8309.9816 BF_2 3.00 2.93 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9817 BF_2 13.58 0.36 1871 751231572 XP_011169356.1 766 1.8e-78 PREDICTED: uncharacterized protein LOC105202492 [Solenopsis invicta] -- -- -- -- -- -- -- -- -- -- -- -- -- PF05225//PF04218//PF03184 helix-turn-helix, Psq domain//CENP-B N-terminal DNA-binding domain//DDE superfamily endonuclease -- -- GO:0003677//GO:0003676 DNA binding//nucleic acid binding -- -- -- -- Cluster-8309.9819 BF_2 27.49 1.06 1374 270007404 EFA03852.1 437 1.9e-40 hypothetical protein TcasGA2_TC013968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9821 BF_2 28.18 0.60 2260 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9824 BF_2 40.68 1.38 1517 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9829 BF_2 9.28 0.32 1504 625188915 XP_007627044.1 462 2.6e-43 PREDICTED: zinc finger protein 2 isoform X2 [Cricetulus griseus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q9Y6Q3 462 1.1e-44 Zinc finger protein 37 homolog OS=Homo sapiens GN=ZFP37 PE=2 SV=3 PF13912//PF00320//PF16622//PF00096//PF13465//PF00130 C2H2-type zinc finger//GATA zinc finger//zinc-finger C2H2-type//Zinc finger, C2H2 type//Zinc-finger double domain//Phorbol esters/diacylglycerol binding domain (C1 domain) GO:0006355//GO:0035556 regulation of transcription, DNA-templated//intracellular signal transduction GO:0008270//GO:0043565//GO:0003700//GO:0046872 zinc ion binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding//metal ion binding GO:0005667 transcription factor complex -- -- Cluster-8309.9832 BF_2 19.10 0.70 1431 821123351 XP_012384018.1 634 2.8e-63 PREDICTED: zinc finger protein 420-like [Dasypus novemcinctus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 Q8N184 615 1.9e-62 Zinc finger protein 567 OS=Homo sapiens GN=ZNF567 PE=1 SV=3 PF00096//PF13465//PF13912//PF16622 Zinc finger, C2H2 type//Zinc-finger double domain//C2H2-type zinc finger//zinc-finger C2H2-type -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-8309.9834 BF_2 15.52 0.32 2336 667281488 XP_008574444.1 797 5.8e-82 PREDICTED: zinc finger protein 778-like [Galeopterus variegatus] -- -- -- -- -- K09228 KRAB KRAB domain-containing zinc finger protein http://www.genome.jp/dbget-bin/www_bget?ko:K09228 P10076 769 4.2e-80 Zinc finger protein 26 OS=Mus musculus GN=Zfp26 PE=2 SV=2 PF13912//PF07776//PF00935//PF13465//PF00096//PF01155 C2H2-type zinc finger//Zinc-finger associated domain (zf-AD)//Ribosomal protein L44//Zinc-finger double domain//Zinc finger, C2H2 type//Hydrogenase/urease nickel incorporation, metallochaperone, hypA GO:0006412//GO:0006464//GO:0042254 translation//cellular protein modification process//ribosome biogenesis GO:0016151//GO:0046872//GO:0008270//GO:0003735 nickel cation binding//metal ion binding//zinc ion binding//structural constituent of ribosome GO:0005634//GO:0005840//GO:0005622 nucleus//ribosome//intracellular -- -- Cluster-8309.9837 BF_2 38.00 1.61 1273 86279289 ABC88740.1 506 1.8e-48 putative serine proteinase [Tenebrio molitor] -- -- -- -- -- K01311 CTRC chymotrypsin C http://www.genome.jp/dbget-bin/www_bget?ko:K01311 O97398 494 1.8e-48 Chymotrypsin OS=Phaedon cochleariae PE=2 SV=1 PF00089 Trypsin GO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity -- -- -- -- Cluster-8309.9854 BF_2 1.00 0.59 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9856 BF_2 28.00 1.48 1077 765336429 XP_011493101.1 237 2.3e-17 AAEL017480-PA, partial [Aedes aegypti]>gi|403182585|gb|EJY57493.1| AAEL017480-PA, partial [Aedes aegypti] -- -- -- -- -- K15503 ANKRD44 serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B http://www.genome.jp/dbget-bin/www_bget?ko:K15503 Q5UPA0 223 4.0e-17 Putative ankyrin repeat protein L25 OS=Acanthamoeba polyphaga mimivirus GN=MIMI_L25 PE=3 SV=1 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.9857 BF_2 4.00 8.22 284 780086179 XP_011673431.1 256 3.8e-20 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like [Strongylocentrotus purpuratus] -- -- -- -- -- K12329 PPP1R12B, MYPT2 protein phosphatase 1 regulatory subunit 12B http://www.genome.jp/dbget-bin/www_bget?ko:K12329 Q4UMH6 225 6.1e-18 Putative ankyrin repeat protein RF_0381 OS=Rickettsia felis (strain ATCC VR-1525 / URRWXCal2) GN=RF_0381 PE=3 SV=1 PF00023//PF13606 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9864 BF_2 13.00 0.57 1234 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9871 BF_2 30.51 1.55 1110 270007404 EFA03852.1 443 3.1e-41 hypothetical protein TcasGA2_TC013968 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02228 Major core protein p19 -- -- GO:0005198 structural molecule activity GO:0019013 viral nucleocapsid -- -- Cluster-8309.9873 BF_2 2.00 0.48 461 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9887 BF_2 30.00 0.48 2892 642924880 XP_008194081.1 597 1.1e-58 PREDICTED: golgin subfamily B member 1-like isoform X3 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P25386 259 7.2e-21 Intracellular protein transport protein USO1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=USO1 PE=1 SV=2 PF04508//PF04111//PF02570 Viral A-type inclusion protein repeat//Autophagy protein Apg6//Precorrin-8X methylmutase GO:0016032//GO:0006914//GO:0015994//GO:0009236 viral process//autophagy//chlorophyll metabolic process//cobalamin biosynthetic process GO:0016993 precorrin-8X methylmutase activity -- -- -- -- Cluster-8309.9889 BF_2 4.40 0.64 575 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9891 BF_2 2.00 0.41 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9900 BF_2 58.16 1.24 2242 642936652 XP_008198524.1 1161 3.5e-124 PREDICTED: tetratricopeptide repeat protein 17-like isoform X1 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q96AE7 166 3.4e-10 Tetratricopeptide repeat protein 17 OS=Homo sapiens GN=TTC17 PE=1 SV=1 PF13414//PF13176//PF13374//PF00515//PF13371//PF02207//PF13181//PF02064 TPR repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Tetratricopeptide repeat//Putative zinc finger in N-recognin (UBR box)//Tetratricopeptide repeat//MAS20 protein import receptor GO:0006605//GO:0006886 protein targeting//intracellular protein transport GO:0008270//GO:0005515 zinc ion binding//protein binding GO:0005742 mitochondrial outer membrane translocase complex -- -- Cluster-8309.9903 BF_2 18.00 0.43 2058 478255618 ENN75831.1 1483 1.5e-161 hypothetical protein YQE_07639, partial [Dendroctonus ponderosae]>gi|546670991|gb|ERL83518.1| hypothetical protein D910_00555 [Dendroctonus ponderosae]>gi|546682737|gb|ERL92639.1| hypothetical protein D910_09952 [Dendroctonus ponderosae] 642916697 XM_001812646.2 242 2.75517e-121 PREDICTED: Tribolium castaneum fork head domain-containing protein crocodile (LOC100142409), mRNA K09396 FOXC forkhead box protein C http://www.genome.jp/dbget-bin/www_bget?ko:K09396 P32027 615 2.7e-62 Fork head domain-containing protein crocodile OS=Drosophila melanogaster GN=croc PE=2 SV=2 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0043565 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8309.9907 BF_2 46.04 2.02 1242 478261429 ENN80805.1 567 1.4e-55 hypothetical protein YQE_02776, partial [Dendroctonus ponderosae]>gi|546676512|gb|ERL87506.1| hypothetical protein D910_04898 [Dendroctonus ponderosae] -- -- -- -- -- K04513 RHOA Ras homolog gene family, member A http://www.genome.jp/dbget-bin/www_bget?ko:K04513 Q24192 392 1.2e-36 Ras-like GTP-binding protein RhoL OS=Drosophila melanogaster GN=RhoL PE=2 SV=1 PF08477//PF00071//PF00025 Ras of Complex, Roc, domain of DAPkinase//Ras family//ADP-ribosylation factor family GO:0007264 small GTPase mediated signal transduction GO:0005525 GTP binding -- -- KOG0393 Ras-related small GTPase, Rho type Cluster-8309.9918 BF_2 22.40 0.94 1289 642921320 XP_008192819.1 556 2.8e-54 PREDICTED: uncharacterized protein LOC103312853 isoform X1 [Tribolium castaneum] -- -- -- -- -- K17102 EHF ETS homologous factor http://www.genome.jp/dbget-bin/www_bget?ko:K17102 P78545 278 2.0e-23 ETS-related transcription factor Elf-3 OS=Homo sapiens GN=ELF3 PE=1 SV=1 PF00178 Ets-domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG3804 Transcription factor NERF and related proteins, contain ETS domain Cluster-8309.9923 BF_2 4.00 0.68 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9925 BF_2 3.00 0.43 576 546678121 ERL88830.1 507 6.0e-49 hypothetical protein D910_06212 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9934 BF_2 46.95 2.35 1122 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF14604 Variant SH3 domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8309.9936 BF_2 31.00 1.42 1199 57791222 AAW56441.1 311 6.7e-26 PR-5-like protein [Diaprepes abbreviatus] -- -- -- -- -- -- -- -- -- P50699 144 6.4e-08 Thaumatin-like protein OS=Arabidopsis thaliana GN=At1g18250 PE=2 SV=2 PF01819 Levivirus coat protein -- -- GO:0005198 structural molecule activity GO:0019028 viral capsid -- -- Cluster-8309.9941 BF_2 33.00 1.15 1483 826407576 XP_012543665.1 570 7.7e-56 PREDICTED: putative nuclease HARBI1 [Monomorium pharaonis] -- -- -- -- -- -- -- -- -- Q96MB7 147 3.6e-08 Putative nuclease HARBI1 OS=Homo sapiens GN=HARBI1 PE=1 SV=1 PF04827//PF01609//PF09339//PF02796 Plant transposon protein//Transposase DDE domain//IclR helix-turn-helix domain//Helix-turn-helix domain of resolvase GO:0006355//GO:0006310//GO:0006313 regulation of transcription, DNA-templated//DNA recombination//transposition, DNA-mediated GO:0016788//GO:0003677//GO:0000150//GO:0004803 hydrolase activity, acting on ester bonds//DNA binding//recombinase activity//transposase activity -- -- -- -- Cluster-8309.9958 BF_2 20.87 0.87 1288 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF05485 THAP domain -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8309.996 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9964 BF_2 15.76 0.53 1535 699247593 XP_009860083.1 155 1.1e-07 PREDICTED: uncharacterized protein LOC100183481 [Ciona intestinalis] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03938//PF00015//PF02346//PF03095//PF07962//PF06009//PF07851//PF04111//PF00435//PF04048//PF04336//PF16752 Outer membrane protein (OmpH-like)//Methyl-accepting chemotaxis protein (MCP) signalling domain//Chordopoxvirus multifunctional envelope protein A27//Phosphotyrosyl phosphate activator (PTPA) protein//Replication Fork Protection Component Swi3//Laminin Domain II//TMPIT-like protein//Autophagy protein Apg6//Spectrin repeat//Sec8 exocyst complex component specific domain//Protein of unknown function, DUF479//Tubulin-specific chaperone C N-terminal domain GO:0006633//GO:0019064//GO:0006904//GO:0007155//GO:0015940//GO:0007165//GO:0006974//GO:0006914//GO:0015031//GO:0048478//GO:0007049 fatty acid biosynthetic process//fusion of virus membrane with host plasma membrane//vesicle docking involved in exocytosis//cell adhesion//pantothenate biosynthetic process//signal transduction//cellular response to DNA damage stimulus//autophagy//protein transport//replication fork protection//cell cycle GO:0005515//GO:0015631//GO:0019211//GO:0004871//GO:0008770//GO:0051082 protein binding//tubulin binding//phosphatase activator activity//signal transducer activity//[acyl-carrier-protein] phosphodiesterase activity//unfolded protein binding GO:0005634//GO:0019031//GO:0016020//GO:0000145//GO:0016021//GO:0045298 nucleus//viral envelope//membrane//exocyst//integral component of membrane//tubulin complex -- -- Cluster-8309.9969 BF_2 16.00 1.17 860 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9970 BF_2 11.00 0.53 1160 91094083 XP_970629.1 177 2.3e-10 PREDICTED: dehydrogenase/reductase SDR family member 11 [Tribolium castaneum]>gi|270016176|gb|EFA12624.1| hypothetical protein TcasGA2_TC010257 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- D2WKD9 134 9.0e-07 Farnesol dehydrogenase OS=Aedes aegypti GN=SDR-1 PE=1 SV=2 PF00106 short chain dehydrogenase GO:0008152 metabolic process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8309.9978 BF_2 18.00 0.50 1788 817061123 XP_012252151.1 308 2.2e-25 PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae]>gi|817061125|ref|XP_012252152.1| PREDICTED: uncharacterized protein LOC105683818 [Athalia rosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07728//PF00580//PF00448 AAA domain (dynein-related subfamily)//UvrD/REP helicase N-terminal domain//SRP54-type protein, GTPase domain GO:0006614 SRP-dependent cotranslational protein targeting to membrane GO:0005525//GO:0005524//GO:0016887 GTP binding//ATP binding//ATPase activity -- -- -- -- Cluster-8309.9979 BF_2 84.00 0.83 4531 390362249 XP_001190749.2 1897 3.2e-209 PREDICTED: serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A-like, partial [Strongylocentrotus purpuratus] -- -- -- -- -- -- -- -- -- P16157 1019 8.4e-109 Ankyrin-1 OS=Homo sapiens GN=ANK1 PE=1 SV=3 PF13606//PF00023 Ankyrin repeat//Ankyrin repeat -- -- GO:0005515 protein binding -- -- KOG4177 Ankyrin Cluster-8309.998 BF_2 23.00 1.37 990 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8309.9982 BF_2 115.24 5.02 1247 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04923 Ninjurin GO:0042246//GO:0007155 tissue regeneration//cell adhesion -- -- GO:0016021 integral component of membrane -- -- Cluster-8309.9999 BF_2 10.00 3.02 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8310.0 BF_2 3.00 0.51 533 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8311.0 BF_2 4.00 0.83 489 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8312.0 BF_2 3.00 1.52 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8317.0 BF_2 3.00 0.39 609 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8318.0 BF_2 7.00 0.68 716 317419426 CBN81463.1 297 1.7e-24 Probable phosphatase phospho1 [Dicentrarchus labrax] 823228188 XM_012591408.1 167 4.5745e-80 PREDICTED: Gossypium raimondii inorganic pyrophosphatase 1-like (LOC105770281), mRNA K06124 PHOSPHO1 phosphoethanolamine/phosphocholine phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K06124 Q9FZ62 583 4.8e-59 Inorganic pyrophosphatase 2 OS=Arabidopsis thaliana GN=At1g17710 PE=2 SV=1 PF06888 Putative Phosphatase GO:0008152 metabolic process GO:0016791 phosphatase activity -- -- KOG3120 Predicted haloacid dehalogenase-like hydrolase Cluster-8319.0 BF_2 15.00 0.90 984 -- -- -- -- -- 694434585 XM_009346234.1 161 1.37932e-76 PREDICTED: Pyrus x bretschneideri transcription factor MYC2-like (LOC103936401), partial mRNA -- -- -- -- Q39204 556 8.9e-56 Transcription factor MYC2 OS=Arabidopsis thaliana GN=MYC2 PE=1 SV=2 PF01006//PF00010 Hepatitis C virus non-structural protein NS4a//Helix-loop-helix DNA-binding domain GO:0016032 viral process GO:0046983 protein dimerization activity GO:0019012 virion -- -- Cluster-8325.0 BF_2 9.00 1.11 627 -- -- -- -- -- 694323628 XM_009354599.1 52 3.37102e-16 PREDICTED: Pyrus x bretschneideri ethylene-responsive transcription factor 4-like (LOC103944178), transcript variant X2, mRNA -- -- -- -- O80340 170 3.2e-11 Ethylene-responsive transcription factor 4 OS=Arabidopsis thaliana GN=ERF4 PE=1 SV=1 PF00847 AP2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8327.0 BF_2 2.00 0.39 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8337.0 BF_2 3.00 0.54 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00951 Arterivirus GL envelope glycoprotein -- -- -- -- GO:0019031 viral envelope -- -- Cluster-8342.0 BF_2 2.00 0.59 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8347.0 BF_2 14.00 1.97 584 766934358 XP_011499494.1 299 8.1e-25 PREDICTED: 60S ribosomal protein L31 [Ceratosolen solmsi marchali]>gi|766934360|ref|XP_011499495.1| PREDICTED: 60S ribosomal protein L31 [Ceratosolen solmsi marchali] 156764218 AK287603.1 581 0 Oryza sativa Japonica Group cDNA, clone: J065054C11, full insert sequence K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 P46290 428 3.7e-41 60S ribosomal protein L31 OS=Nicotiana glutinosa GN=RPL31 PE=2 SV=1 PF01198 Ribosomal protein L31e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG0893 60S ribosomal protein L31 Cluster-8351.0 BF_2 4.31 0.62 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8352.0 BF_2 9.00 2.41 443 224028157 CAX48991.1 261 1.6e-20 water and ammonia transporting aquaporin [Lumbricus rubellus] 238814673 FJ971056.1 425 0 Juglans regia plasma intrinsic protein 2;3 mRNA, complete cds K09864 AQP1 aquaporin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K09864 Q9ATM4 635 2.7e-65 Aquaporin PIP2-7 OS=Zea mays GN=PIP2-7 PE=2 SV=1 PF00230 Major intrinsic protein GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8356.1 BF_2 4.00 0.40 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8357.0 BF_2 3.00 0.51 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8359.0 BF_2 3.00 0.31 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8364.0 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8367.0 BF_2 3.00 1.06 404 305689987 ADM64420.1 382 1.3e-34 copper/zinc superoxide dismutase [Alitta succinea] 38228696 AJ586519.1 171 1.48758e-82 Fagus sylvatica partial sod1 mRNA for superoxide dismutase K04565 SOD1 superoxide dismutase, Cu-Zn family http://www.genome.jp/dbget-bin/www_bget?ko:K04565 P23346 410 3.1e-39 Superoxide dismutase [Cu-Zn] 4AP OS=Zea mays GN=SODCC.2 PE=2 SV=2 PF00080 Copper/zinc superoxide dismutase (SODC) GO:0055114//GO:0006801 oxidation-reduction process//superoxide metabolic process GO:0046872 metal ion binding -- -- KOG0441 Cu2+/Zn2+ superoxide dismutase SOD1 Cluster-8368.0 BF_2 1.00 0.60 352 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8370.0 BF_2 1.00 0.59 354 719749139 XP_010212325.1 206 3.0e-14 PREDICTED: uncharacterized protein LOC104567219, partial [Tinamus guttatus] 325260834 HM999008.1 336 2.43567e-174 Oryza nivara clone BAC ORBBa0014L06, complete sequence -- -- -- -- -- -- -- -- PF06466//PF00098 PCAF (P300/CBP-associated factor) N-terminal domain//Zinc knuckle GO:0042967//GO:0006355 acyl-carrier-protein biosynthetic process//regulation of transcription, DNA-templated GO:0004402//GO:0008270//GO:0003676 histone acetyltransferase activity//zinc ion binding//nucleic acid binding GO:0000123//GO:0005634 histone acetyltransferase complex//nucleus -- -- Cluster-8373.0 BF_2 2.00 0.58 432 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8373.1 BF_2 21.00 0.98 1183 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8374.0 BF_2 3.00 1.44 372 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8375.0 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8378.0 BF_2 6.00 2.49 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8379.0 BF_2 15.00 0.37 1967 642932646 XP_008196932.1 1798 4.1e-198 PREDICTED: sodium-independent sulfate anion transporter-like [Tribolium castaneum]>gi|270011532|gb|EFA07980.1| hypothetical protein TcasGA2_TC005562 [Tribolium castaneum] -- -- -- -- -- K14708 SLC26A11 solute carrier family 26 (sodium-independent sulfate anion transporter), member 11 http://www.genome.jp/dbget-bin/www_bget?ko:K14708 Q80ZD3 933 3.4e-99 Sodium-independent sulfate anion transporter OS=Mus musculus GN=Slc26a11 PE=2 SV=2 PF04042//PF00916//PF16983 DNA polymerase alpha/epsilon subunit B//Sulfate permease family//Molybdate transporter of MFS superfamily GO:0008272//GO:0015689//GO:0006260 sulfate transport//molybdate ion transport//DNA replication GO:0003887//GO:0015116//GO:0003677//GO:0015098 DNA-directed DNA polymerase activity//sulfate transmembrane transporter activity//DNA binding//molybdate ion transmembrane transporter activity GO:0042575//GO:0016021//GO:0016020 DNA polymerase complex//integral component of membrane//membrane KOG0236 Sulfate/bicarbonate/oxalate exchanger SAT-1 and related transporters (SLC26 family) Cluster-8381.0 BF_2 7.00 1.70 459 31753114 AAH53854.1 278 1.7e-22 Unknown (protein for IMAGE:5194336), partial [Homo sapiens]>gi|111494016|gb|AAI11385.1| Unknown (protein for IMAGE:5198300), partial [Homo sapiens] 764594105 XM_004300624.2 184 1.01358e-89 PREDICTED: Fragaria vesca subsp. vesca chlorophyll a-b binding protein CP26, chloroplastic (LOC101295423), mRNA -- -- -- -- Q9XF89 456 1.6e-44 Chlorophyll a-b binding protein CP26, chloroplastic OS=Arabidopsis thaliana GN=LHCB5 PE=1 SV=1 PF07646 Kelch motif -- -- GO:0005515 protein binding -- -- -- -- Cluster-8386.0 BF_2 3.00 5.35 290 -- -- -- -- -- 571439425 XM_006574794.1 35 4.1212e-07 PREDICTED: Glycine max heat shock cognate 70 kDa protein 2-like (LOC100789474), mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8388.0 BF_2 5.00 0.32 942 21265101 NP_055035.1 1039 2.0e-110 transmembrane 4 L6 family member 1 [Homo sapiens]>gi|267068|sp|P30408.1|T4S1_HUMAN RecName: Full=Transmembrane 4 L6 family member 1; AltName: Full=Membrane component chromosome 3 surface marker 1; AltName: Full=Tumor-associated antigen L6>gi|186804|gb|AAA36158.1| L6 [Homo sapiens]>gi|14250075|gb|AAH08442.1| Transmembrane 4 L six family member 1 [Homo sapiens]>gi|14603438|gb|AAH10166.1| Transmembrane 4 L six family member 1 [Homo sapiens]>gi|48146023|emb|CAG33234.1| TM4SF1 [Homo sapiens]>gi|119599281|gb|EAW78875.1| transmembrane 4 L six family member 1, isoform CRA_b [Homo sapiens] 34527037 AK130271.1 942 0 Homo sapiens cDNA FLJ26761 fis, clone PRS02543, highly similar to Transmembrane 4 superfamily, member 1 -- -- -- -- P30408 1039 8.3e-112 Transmembrane 4 L6 family member 1 OS=Homo sapiens GN=TM4SF1 PE=1 SV=1 PF06455//PF05805//PF04893 NADH dehydrogenase subunit 5 C-terminus//L6 membrane protein//Yip1 domain GO:0042773//GO:0006120//GO:0055114//GO:0015992//GO:0006814//GO:0006744 ATP synthesis coupled electron transport//mitochondrial electron transport, NADH to ubiquinone//oxidation-reduction process//proton transport//sodium ion transport//ubiquinone biosynthetic process GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0016021//GO:0005887//GO:0016020 integral component of membrane//integral component of plasma membrane//membrane -- -- Cluster-8389.0 BF_2 52.00 219.90 258 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8398.0 BF_2 2.00 0.33 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8401.0 BF_2 4.00 0.43 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8402.0 BF_2 20.00 2.06 693 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8405.0 BF_2 1.00 0.40 390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8406.0 BF_2 1.00 0.52 364 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q8VYW2 218 5.1e-17 Inactive beta-amylase 9 OS=Arabidopsis thaliana GN=BAM9 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8411.0 BF_2 68.00 13.94 491 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8412.0 BF_2 7.00 0.36 1105 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8423.0 BF_2 2.00 0.40 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8424.0 BF_2 3.34 0.46 588 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8426.1 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8429.0 BF_2 8.00 10.53 304 -- -- -- -- -- 288872657 GU393024.1 106 1.47699e-46 Camellia sinensis ERF transcription factor mRNA, complete cds -- -- -- -- O80338 336 8.9e-31 Ethylene-responsive transcription factor 2 OS=Arabidopsis thaliana GN=ERF2 PE=2 SV=1 PF00847 AP2 domain GO:0006355 regulation of transcription, DNA-templated GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex -- -- Cluster-8429.1 BF_2 1.00 1.78 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8430.0 BF_2 6.00 1.63 441 -- -- -- -- -- 347662195 BT132548.1 438 0 Oryza sativa clone RRlibC00122 mRNA sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8443.0 BF_2 5.00 0.46 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8446.0 BF_2 1.00 0.57 357 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8447.0 BF_2 15.00 281.97 218 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8450.1 BF_2 2.00 0.38 509 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8455.0 BF_2 1.00 2.52 276 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8456.0 BF_2 1.00 0.63 349 795097298 XP_011828720.1 588 1.5e-58 PREDICTED: alpha-actinin-4 [Mandrillus leucophaeus] 823670515 KR710087.1 349 0 Synthetic construct Homo sapiens clone CCSBHm_00009357 ACTN4 (ACTN4) mRNA, encodes complete protein K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 Q5RCS6 588 6.1e-60 Alpha-actinin-4 OS=Pongo abelii GN=ACTN4 PE=2 SV=1 PF00435//PF15745//PF09732 Spectrin repeat//AP-1 complex-associated regulatory protein//Cactus-binding C-terminus of cactin protein GO:0048203//GO:0034315//GO:1900025//GO:2000146 vesicle targeting, trans-Golgi to endosome//regulation of Arp2/3 complex-mediated actin nucleation//negative regulation of substrate adhesion-dependent cell spreading//negative regulation of cell motility GO:0005515//GO:0035650 protein binding//AP-1 adaptor complex binding -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8456.2 BF_2 1.00 0.38 396 73947736 XP_867419.1 677 8.1e-69 PREDICTED: alpha-actinin-4 isoformX11 [Canis lupus familiaris] 795209215 XM_011949696.1 344 9.83657e-179 PREDICTED: Colobus angolensis palliatus actinin, alpha 1 (ACTN1), transcript variant X5, mRNA K05699 ACTN actinin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K05699 P57780 674 7.4e-70 Alpha-actinin-4 OS=Mus musculus GN=Actn4 PE=1 SV=1 PF00435 Spectrin repeat -- -- GO:0005515 protein binding -- -- KOG0035 Ca2+-binding actin-bundling protein (actinin), alpha chain (EF-Hand protein superfamily) Cluster-8457.0 BF_2 1.00 0.31 423 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8459.0 BF_2 5.00 0.39 830 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8465.0 BF_2 1.00 0.55 359 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8466.0 BF_2 3.00 3.44 311 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Q9M9H6 379 9.3e-36 Probable choline kinase 1 OS=Arabidopsis thaliana GN=CK1 PE=2 SV=1 PF04428 Choline kinase N terminus -- -- GO:0016773 phosphotransferase activity, alcohol group as acceptor -- -- KOG2686 Choline kinase Cluster-8468.0 BF_2 2.00 0.32 551 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8470.0 BF_2 1.00 0.47 374 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8473.0 BF_2 2.00 0.36 521 269316054 XP_641372.4 489 6.7e-47 NAD+ dependent glutamate dehydrogenase [Dictyostelium discoideum AX4]>gi|263432342|sp|Q54VI3.2|GLUD2_DICDI RecName: Full=Glutamate dehydrogenase 2; AltName: Full=NAD-specific glutamate dehydrogenase; Short=NAD-GDH>gi|165988616|gb|EAL67386.2| NAD+ dependent glutamate dehydrogenase [Dictyostelium discoideum AX4] 768311755 CP010983.1 515 0 Verticillium dahliae VdLs.17 chromosome 4, complete sequence -- -- -- -- P00365 710 6.5e-74 NAD-specific glutamate dehydrogenase OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=gdh-1 PE=1 SV=4 PF00208 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase GO:0006520//GO:0055114 cellular amino acid metabolic process//oxidation-reduction process GO:0016491 oxidoreductase activity -- -- -- -- Cluster-8475.0 BF_2 5.00 0.67 601 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8476.0 BF_2 4.00 0.37 744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8482.0 BF_2 5.00 0.56 659 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8484.1 BF_2 1.00 0.93 323 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8486.0 BF_2 9.00 1.51 537 861488243 XP_004865230.2 360 6.3e-32 PREDICTED: discoidin domain-containing receptor 2 [Heterocephalus glaber] 282721095 NG_016290.1 537 0 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 K05125 DDR2, TKT discoidin domain receptor family member 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05125 Q16832 344 1.8e-31 Discoidin domain-containing receptor 2 OS=Homo sapiens GN=DDR2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8487.0 BF_2 1.00 0.44 381 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8492.0 BF_2 6.00 0.88 573 -- -- -- -- -- 528540458 AP012528.1 573 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- -- -- -- -- PF04901 Receptor activity modifying family GO:0015031//GO:0006886//GO:0008277 protein transport//intracellular protein transport//regulation of G-protein coupled receptor protein signaling pathway GO:0008565 protein transporter activity GO:0016021 integral component of membrane -- -- Cluster-8500.0 BF_2 5.00 1.47 429 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8503.0 BF_2 2.00 0.35 523 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8508.0 BF_2 3.00 0.34 656 642913896 XP_008201204.1 380 3.7e-34 PREDICTED: uncharacterized protein LOC103315117 [Tribolium castaneum]>gi|270001647|gb|EEZ98094.1| hypothetical protein TcasGA2_TC000507 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF02714 Calcium-dependent channel, 7TM region, putative phosphate -- -- -- -- GO:0016020 membrane -- -- Cluster-8513.0 BF_2 7.00 45.51 245 -- -- -- -- -- 670402702 XM_008683015.1 245 6.20969e-124 PREDICTED: Zea mays responsive to abscisic acid15 (LOC100194217), transcript variant X1, mRNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8515.0 BF_2 2.00 0.42 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8516.0 BF_2 12.00 3.52 429 528762267 EPY81926.1 306 9.1e-26 hypothetical protein CB1_000693011 [Camelus ferus] 383087749 NG_012113.2 429 0 Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (PIK3CA), RefSeqGene (LRG_310) on chromosome 3 K00922 PIK3C phosphatidylinositol-4,5-bisphosphate 3-kinase http://www.genome.jp/dbget-bin/www_bget?ko:K00922 P32871 300 1.9e-26 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform OS=Bos taurus GN=PIK3CA PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8521.0 BF_2 7.00 0.88 621 301500947 YP_003795412.1 385 9.2e-35 photosystem I subunit VII [Alveolata sp. CCMP3155]>gi|300069493|gb|ADJ66600.1| photosystem I subunit VII (chloroplast) [Chromerida sp. RM11] 761231605 KM881639.1 621 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- A1YV30 449 1.4e-43 Photosystem I iron-sulfur center OS=Secale cereale GN=psaC PE=3 SV=1 PF05187 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S GO:0006118//GO:0055114//GO:0009773 obsolete electron transport//oxidation-reduction process//photosynthetic electron transport in photosystem I GO:0004174//GO:0009055//GO:0046872//GO:0051539//GO:0016491 electron-transferring-flavoprotein dehydrogenase activity//electron carrier activity//metal ion binding//4 iron, 4 sulfur cluster binding//oxidoreductase activity GO:0009535//GO:0009522 chloroplast thylakoid membrane//photosystem I -- -- Cluster-8526.0 BF_2 3.00 0.49 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8528.0 BF_2 7.00 1.06 563 32307466 AAP79138.1 204 8.1e-14 chlorophyll a/b-binding protein II 2 [Bigelowiella natans] 571524745 XM_003547970.2 237 4.33739e-119 PREDICTED: Glycine max chlorophyll a-b binding protein 7, chloroplastic-like (LOC100802138), transcript variant 1, mRNA -- -- -- -- P13869 589 7.5e-60 Chlorophyll a-b binding protein, chloroplastic OS=Petunia hybrida PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8533.0 BF_2 1.00 0.51 367 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8537.0 BF_2 6.00 1.87 421 857972262 CEP01299.1 596 2.1e-59 hypothetical protein PBRA_001905 [Plasmodiophora brassicae] 645243031 XM_008229574.1 299 1.08926e-153 PREDICTED: Prunus mume S-adenosylmethionine synthase 1 (LOC103327270), mRNA K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 Q9AT56 746 3.5e-78 S-adenosylmethionine synthase 1 OS=Elaeagnus umbellata GN=SAMS1 PE=2 SV=1 PF02772//PF02773 S-adenosylmethionine synthetase, central domain//S-adenosylmethionine synthetase, C-terminal domain GO:0006555//GO:0006556 methionine metabolic process//S-adenosylmethionine biosynthetic process GO:0004478 methionine adenosyltransferase activity -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8541.0 BF_2 7.00 2.04 430 296228912 XP_002760026.1 371 2.6e-33 PREDICTED: protein S100-A6 [Callithrix jacchus]>gi|675743194|ref|XP_008982676.1| PREDICTED: protein S100-A6 [Callithrix jacchus]>gi|725602175|ref|XP_010327959.1| PREDICTED: protein S100-A6 [Saimiri boliviensis boliviensis]>gi|725602177|ref|XP_010327960.1| PREDICTED: protein S100-A6 [Saimiri boliviensis boliviensis]>gi|817333568|ref|XP_012293724.1| PREDICTED: protein S100-A6 [Aotus nancymaae] 426331645 XM_004026740.1 430 0 PREDICTED: Gorilla gorilla gorilla S100 calcium binding protein A6, transcript variant 1 (S100A6), mRNA -- -- -- -- P06703 374 4.9e-35 Protein S100-A6 OS=Homo sapiens GN=S100A6 PE=1 SV=1 PF13499//PF13405//PF00036 EF-hand domain pair//EF-hand domain//EF hand -- -- GO:0005509 calcium ion binding -- -- -- -- Cluster-8543.0 BF_2 2.00 0.72 403 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8545.0 BF_2 4.00 0.62 559 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8551.0 BF_2 6.00 1.18 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8553.0 BF_2 1.00 0.41 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8554.0 BF_2 4.00 0.74 513 4504981 NP_002296.1 727 1.7e-74 galectin-1 [Homo sapiens]>gi|114686337|ref|XP_001162104.1| PREDICTED: galectin-1 [Pan troglodytes]>gi|397501910|ref|XP_003821617.1| PREDICTED: galectin-1 [Pan paniscus]>gi|126155|sp|P09382.2|LEG1_HUMAN RecName: Full=Galectin-1; Short=Gal-1; AltName: Full=14 kDa laminin-binding protein; Short=HLBP14; AltName: Full=14 kDa lectin; AltName: Full=Beta-galactoside-binding lectin L-14-I; AltName: Full=Galaptin; AltName: Full=HBL; AltName: Full=HPL; AltName: Full=Lactose-binding lectin 1; AltName: Full=Lectin galactoside-binding soluble 1; AltName: Full=Putative MAPK-activating protein PM12; AltName: Full=S-Lac lectin 1>gi|34343|emb|CAA32938.1| unnamed protein product [Homo sapiens]>gi|184228|gb|AAB00777.1| 14 kDa beta-galactoside-binding lectin [Homo sapiens]>gi|307122|gb|AAA36170.1| lectin precursor [Homo sapiens]>gi|4377694|emb|CAA33328.1| 14 kDa beta-galactoside-binding lectin [Homo sapiens]>gi|12804557|gb|AAH01693.1| Lectin, galactoside-binding, soluble, 1 [Homo sapiens]>gi|18088370|gb|AAH20675.1| Lectin, galactoside-binding, soluble, 1 [Homo sapiens]>gi|30582389|gb|AAP35421.1| lectin, galactoside-binding, soluble, 1 (galectin 1) [Homo sapiens]>gi|31455527|dbj|BAC77389.1| putative MAPK activating protein [Homo sapiens]>gi|47678553|emb|CAG30397.1| LGALS1 [Homo sapiens]>gi|61358976|gb|AAX41649.1| lectin galactoside-binding soluble 1 [synthetic construct]>gi|61358983|gb|AAX41650.1| lectin galactoside-binding soluble 1 [synthetic construct]>gi|109451360|emb|CAK54541.1| LGALS1 [synthetic construct]>gi|109451938|emb|CAK54840.1| LGALS1 [synthetic construct]>gi|117646842|emb|CAL37536.1| hypothetical protein [synthetic construct]>gi|119580582|gb|EAW60178.1| lectin, galactoside-binding, soluble, 1 (galectin 1) [Homo sapiens]>gi|123982896|gb|ABM83189.1| lectin, galactoside-binding, soluble, 1 (galectin 1) [synthetic construct]>gi|123997579|gb|ABM86391.1| lectin, galactoside-binding, soluble, 1 (galectin 1) [synthetic construct]>gi|169635015|gb|ACA58297.1| beta-galactoside-binding lectin precursor [Homo sapiens]>gi|189053289|dbj|BAG35095.1| unnamed protein product [Homo sapiens]>gi|208965188|dbj|BAG72608.1| lectin, galactoside-binding, soluble, 1 [synthetic construct]>gi|649101210|gb|AIC49129.1| LGALS1, partial [synthetic construct] 85815826 NM_002305.3 513 0 Homo sapiens lectin, galactoside-binding, soluble, 1 (LGALS1), mRNA K06830 LGALS1 galectin-1 http://www.genome.jp/dbget-bin/www_bget?ko:K06830 P09382 727 6.8e-76 Galectin-1 OS=Homo sapiens GN=LGALS1 PE=1 SV=2 PF00337 Galactoside-binding lectin GO:0042493//GO:0034120//GO:0010812//GO:0010977//GO:0042981//GO:0045445//GO:0033555//GO:0007165//GO:0071407//GO:0043123//GO:0048678//GO:0071333 response to drug//positive regulation of erythrocyte aggregation//negative regulation of cell-substrate adhesion//negative regulation of neuron projection development//regulation of apoptotic process//myoblast differentiation//multicellular organismal response to stress//signal transduction//cellular response to organic cyclic compound//positive regulation of I-kappaB kinase/NF-kappaB signaling//response to axon injury//cellular response to glucose stimulus GO:0001948//GO:0042803//GO:0004871//GO:0043236//GO:0030395//GO:0016936//GO:0030246 glycoprotein binding//protein homodimerization activity//signal transducer activity//laminin binding//lactose binding//galactoside binding//carbohydrate binding GO:0005634//GO:0009986//GO:0005615//GO:0005737//GO:0005578 nucleus//cell surface//extracellular space//cytoplasm//proteinaceous extracellular matrix -- -- Cluster-8558.0 BF_2 2.00 0.73 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8561.0 BF_2 1.00 1.66 293 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8562.0 BF_2 7.00 1.55 476 -- -- -- -- -- 307123448 HM556942.1 222 7.92077e-111 Uncultured bacterium clone BICH750 16S ribosomal RNA gene, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8563.0 BF_2 2.00 0.42 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8568.0 BF_2 5.00 0.36 867 301770683 XP_002920761.1 1191 4.4e-128 PREDICTED: 60S ribosomal protein L7a [Ailuropoda melanoleuca] 158255681 AK291123.1 867 0 Homo sapiens cDNA FLJ78489 complete cds, highly similar to Homo sapiens ribosomal protein L7a (RPL7A), mRNA K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 Q4R5C2 1156 2.1e-125 60S ribosomal protein L7a OS=Macaca fascicularis GN=RPL7A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8572.0 BF_2 8.00 0.54 910 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8577.0 BF_2 13.00 1.38 681 573893538 XP_006634521.1 352 6.8e-31 PREDICTED: eukaryotic translation initiation factor 1b-like [Lepisosteus oculatus] 595904588 XM_007213926.1 238 1.47496e-119 Prunus persica hypothetical protein (PRUPE_ppa013607mg) mRNA, complete cds K03113 EIF1, SUI1 translation initiation factor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03113 P41568 541 3.4e-54 Protein translation factor SUI1 homolog 1 OS=Arabidopsis thaliana GN=At4g27130 PE=1 SV=2 PF01253 Translation initiation factor SUI1 GO:0006446//GO:0006413 regulation of translational initiation//translational initiation GO:0003743 translation initiation factor activity GO:0005840 ribosome KOG1770 Translation initiation factor 1 (eIF-1/SUI1) Cluster-8580.0 BF_2 11.00 1.12 698 5419753 CAB46483.1 393 1.2e-35 RET tyrosine kinase receptor [Homo sapiens] 336042953 JF273638.1 698 0 Homo sapiens genotype p.R67H/V292M/R982C ret proto-oncogene tyrosine-protein kinase receptor isoform a (RET) gene, complete cds K05126 RET proto-oncogene tyrosine-protein kinase Ret http://www.genome.jp/dbget-bin/www_bget?ko:K05126 P07949 393 5.0e-37 Proto-oncogene tyrosine-protein kinase receptor Ret OS=Homo sapiens GN=RET PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8581.0 BF_2 3.00 0.84 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8582.0 BF_2 14.00 2.44 527 617553317 XP_007530025.1 144 6.8e-07 PREDICTED: uncharacterized protein LOC103119649 [Erinaceus europaeus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8586.0 BF_2 7.00 1.26 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- D1MI46 324 3.7e-29 Geraniol 8-hydroxylase OS=Swertia mussotii GN=CYP76B10 PE=1 SV=1 PF00067 Cytochrome P450 GO:0055114 oxidation-reduction process GO:0005506//GO:0020037//GO:0016705 iron ion binding//heme binding//oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen -- -- -- -- Cluster-8587.0 BF_2 1.00 0.33 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8591.0 BF_2 3.00 1.06 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8592.0 BF_2 3.00 0.55 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8595.0 BF_2 7.00 0.71 699 -- -- -- -- -- 764020144 NR_002819.3 699 0 Homo sapiens metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) (MALAT1), long non-coding RNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8600.0 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8608.0 BF_2 21.00 3.47 540 -- -- -- -- -- 115461692 NM_001060981.1 540 0 Oryza sativa Japonica Group Os05g0111200 (Os05g0111200) mRNA, complete cds -- -- -- -- Q41050 507 2.3e-50 Outer envelope pore protein 16, chloroplastic OS=Pisum sativum GN=OEP16 PE=1 SV=1 PF05433//PF05818 Glycine zipper 2TM domain//Enterobacterial TraT complement resistance protein GO:0046999 regulation of conjugation -- -- GO:0019867 outer membrane -- -- Cluster-8610.0 BF_2 40.00 2.13 1072 642913969 XP_008201495.1 751 5.7e-77 PREDICTED: tailless isoform X1 [Tribolium castaneum] 687941289 LL020897.1 42 2.13734e-10 Trichobilharzia regenti genome assembly T_regenti_v1_0_4 ,scaffold TRE_scaffold0020872 K08545 NR2E1, TLX, tll nuclear receptor subfamily 2 group E member 1 http://www.genome.jp/dbget-bin/www_bget?ko:K08545 P70052 638 3.0e-65 Nuclear receptor subfamily 2 group E member 1 OS=Xenopus laevis GN=nr2e1 PE=2 SV=1 PF00105//PF03910//PF00104 Zinc finger, C4 type (two domains)//Adenovirus minor core protein PV//Ligand-binding domain of nuclear hormone receptor GO:0043401//GO:0006355 steroid hormone mediated signaling pathway//regulation of transcription, DNA-templated GO:0003700//GO:0043565//GO:0008270 transcription factor activity, sequence-specific DNA binding//sequence-specific DNA binding//zinc ion binding GO:0005667//GO:0005634//GO:0019012 transcription factor complex//nucleus//virion -- -- Cluster-8612.0 BF_2 4.00 0.76 507 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8613.0 BF_2 2.00 4.91 277 116283716 AAH32807.1 293 1.9e-24 Unknown (protein for IMAGE:4480714) [Homo sapiens] 8248654 AL136442.12 240 4.30139e-121 Human DNA sequence from clone RP11-25J23 on chromosome 13, complete sequence -- -- -- -- O00370 285 6.6e-25 LINE-1 retrotransposable element ORF2 protein OS=Homo sapiens PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8614.0 BF_2 2.00 0.65 415 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8615.0 BF_2 24.19 1.19 1135 462269586 AGH24292.1 1536 5.7e-168 NADH dehydrogenase subunit 7 (mitochondrion) [Reclinomonas americana ATCC 50633]>gi|462269803|gb|AGH24426.1| NADH dehydrogenase subunit 7 (mitochondrion) [Reclinomonas americana ATCC 50284] 87248043 DQ381459.1 1002 0 Beta vulgaris subsp. vulgaris NADH dehydrogenase subunit 7 (nad7) mRNA, complete cds; mitochondrial K03935 NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2 http://www.genome.jp/dbget-bin/www_bget?ko:K03935 Q36450 1632 1.7e-180 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2 OS=Nicotiana sylvestris GN=NAD7 PE=2 SV=1 PF00346//PF00374 Respiratory-chain NADH dehydrogenase, 49 Kd subunit//Nickel-dependent hydrogenase GO:0055114 oxidation-reduction process GO:0016151//GO:0051287//GO:0048038//GO:0016651 nickel cation binding//NAD binding//quinone binding//oxidoreductase activity, acting on NAD(P)H -- -- KOG2870 NADH:ubiquinone oxidoreductase, NDUFS2/49 kDa subunit Cluster-8616.0 BF_2 5.00 0.70 586 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8618.0 BF_2 3.00 0.94 420 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8620.0 BF_2 3.00 0.31 686 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8626.0 BF_2 7.00 1.62 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8627.0 BF_2 2.80 0.50 523 642910716 XP_008193383.1 265 6.3e-21 PREDICTED: nicotinic acetylcholine receptor alpha6 subunit isoform X1 [Tribolium castaneum] -- -- -- -- -- K05312 CHRNN nicotinic acetylcholine receptor, invertebrate http://www.genome.jp/dbget-bin/www_bget?ko:K05312 P22770 124 5.8e-06 Neuronal acetylcholine receptor subunit alpha-7 OS=Gallus gallus GN=CHRNA7 PE=1 SV=1 PF02931 Neurotransmitter-gated ion-channel ligand binding domain GO:0006811//GO:0006810 ion transport//transport GO:0005230 extracellular ligand-gated ion channel activity GO:0016020 membrane KOG3646 Acetylcholine receptor Cluster-8628.0 BF_2 3.00 0.37 627 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8629.0 BF_2 2.00 0.55 439 307208243 EFN85686.1 231 4.7e-17 hypothetical protein EAI_09677, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00292 'Paired box' domain GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8629.2 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8630.0 BF_2 5.00 0.49 717 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8631.0 BF_2 11.00 1.02 739 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8637.0 BF_2 82.00 3.57 1249 462269584 AGH24290.1 1013 2.8e-107 ATP synthase F1 subunit alpha (mitochondrion) [Reclinomonas americana ATCC 50633] 528540420 AP012527.1 1246 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT98C K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 P0C521 1338 2.4e-146 ATP synthase subunit alpha, mitochondrial OS=Oryza sativa subsp. indica GN=ATPA PE=3 SV=1 PF02874//PF00006 ATP synthase alpha/beta family, beta-barrel domain//ATP synthase alpha/beta family, nucleotide-binding domain GO:0046034//GO:0015992 ATP metabolic process//proton transport GO:0005524 ATP binding -- -- KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-8640.0 BF_2 1.00 0.33 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8644.0 BF_2 17.00 3.20 509 159492355 ABW97364.1 357 1.3e-31 chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit 2 [Amorphochlora amoebiformis] 719968111 XM_010265493.1 200 1.44445e-98 PREDICTED: Nelumbo nucifera ribulose bisphosphate carboxylase small chain, chloroplastic-like (LOC104601969), mRNA -- -- -- -- Q02980 556 4.6e-56 Ribulose bisphosphate carboxylase small chain, chloroplastic OS=Malus sp. GN=RBCS PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8644.1 BF_2 7.00 1.51 481 159492355 ABW97364.1 359 7.3e-32 chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit 2 [Amorphochlora amoebiformis] 719968111 XM_010265493.1 195 8.18199e-96 PREDICTED: Nelumbo nucifera ribulose bisphosphate carboxylase small chain, chloroplastic-like (LOC104601969), mRNA -- -- -- -- Q02980 559 1.9e-56 Ribulose bisphosphate carboxylase small chain, chloroplastic OS=Malus sp. GN=RBCS PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8644.2 BF_2 16.05 1.65 695 159492355 ABW97364.1 342 9.9e-30 chloroplast ribulose-1,5-bisphosphate carboxylase/oxygenase small subunit 2 [Amorphochlora amoebiformis] 1536888 Y07779.1 290 1.86826e-148 Betula pendula mRNA for ribulose-1,5-bisphosphate carboxylase (rbcS gene) -- -- -- -- Q96542 730 4.2e-76 Ribulose bisphosphate carboxylase small chain, chloroplastic OS=Betula pendula GN=RBCS1 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8646.0 BF_2 17.00 2.20 611 404503308 CCJ09772.1 199 3.3e-13 putative non-specific lipid transfer protein, partial [Hirudo medicinalis] 209484144 EU780670.1 276 9.88481e-141 Juglans regia nonspecific lipid transfer protein mRNA, complete cds -- -- -- -- Q9M5X7 292 2.3e-25 Non-specific lipid-transfer protein OS=Malus domestica GN=MALD3 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8651.0 BF_2 2.00 0.51 451 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8653.0 BF_2 2.00 0.32 545 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8655.0 BF_2 5.00 2.95 354 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8657.0 BF_2 3.00 0.91 425 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8658.0 BF_2 2.00 1.31 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8666.0 BF_2 17.00 2.12 623 -- -- -- -- -- 115436721 NM_001049654.1 617 0 Oryza sativa Japonica Group Os01g0393100 (Os01g0393100) mRNA, complete cds -- -- -- -- Q9FKA0 576 2.7e-58 NAC domain-containing protein 92 OS=Arabidopsis thaliana GN=NAC92 PE=1 SV=1 PF02365 No apical meristem (NAM) protein GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding -- -- -- -- Cluster-8670.0 BF_2 2.00 0.32 550 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8673.0 BF_2 8.00 1.15 579 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8679.0 BF_2 1.00 0.49 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8681.0 BF_2 6.00 2.08 407 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8682.0 BF_2 1.00 0.88 326 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8693.0 BF_2 4.00 0.32 815 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8694.0 BF_2 2.00 0.32 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8697.0 BF_2 7.00 1.10 554 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8701.0 BF_2 3.00 0.67 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8703.0 BF_2 8.00 3.79 373 635061619 XP_007964891.1 504 8.7e-49 PREDICTED: UDP-glucuronosyltransferase 1-1 isoform X1 [Chlorocebus sabaeus] 694899481 XM_009444595.1 373 0 PREDICTED: Pan troglodytes UDP-glucuronosyltransferase 1-1 (LOC739942), transcript variant X3, mRNA K00699 UGT glucuronosyltransferase http://www.genome.jp/dbget-bin/www_bget?ko:K00699 P22309 494 5.2e-49 UDP-glucuronosyltransferase 1-1 OS=Homo sapiens GN=UGT1A1 PE=1 SV=1 PF00201 UDP-glucoronosyl and UDP-glucosyl transferase GO:0008152 metabolic process GO:0016758 transferase activity, transferring hexosyl groups -- -- -- -- Cluster-8704.0 BF_2 4.00 0.34 778 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8705.0 BF_2 3.00 0.99 413 642928535 XP_008195364.1 374 1.1e-33 PREDICTED: uncharacterized protein LOC103313570 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8708.0 BF_2 2.00 1.92 321 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8710.1 BF_2 6.00 0.66 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8712.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8714.0 BF_2 11.00 0.84 838 330844029 XP_003293941.1 392 1.9e-35 S-adenosylmethionine synthetase [Dictyostelium purpureum]>gi|325075674|gb|EGC29533.1| S-adenosylmethionine synthetase [Dictyostelium purpureum] 349711979 FQ386162.1 287 1.05726e-146 Vitis vinifera clone SS0AEB2YN10 K00789 metK S-adenosylmethionine synthetase http://www.genome.jp/dbget-bin/www_bget?ko:K00789 Q9AT55 637 3.1e-65 S-adenosylmethionine synthase 2 OS=Elaeagnus umbellata GN=SAMS2 PE=2 SV=1 PF02773 S-adenosylmethionine synthetase, C-terminal domain GO:0006556//GO:0044710//GO:0044237//GO:0006555 S-adenosylmethionine biosynthetic process//single-organism metabolic process//cellular metabolic process//methionine metabolic process GO:0004478//GO:0005488 methionine adenosyltransferase activity//binding -- -- KOG1506 S-adenosylmethionine synthetase Cluster-8716.0 BF_2 1.00 0.34 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8720.1 BF_2 13.00 0.47 1435 45361313 NP_989234.1 1032 2.0e-109 uncharacterized protein LOC394843 [Xenopus (Silurana) tropicalis]>gi|38969870|gb|AAH63367.1| hypothetical protein MGC75973 [Xenopus (Silurana) tropicalis] 308322532 GU588448.1 104 9.8641e-45 Ictalurus furcatus clone CBZF8503 mitochondrial cytochrome c1 heme protein (CY1) mRNA, complete cds; nuclear gene for mitochondrial product K00413 CYC1, CYT1, petC ubiquinol-cytochrome c reductase cytochrome c1 subunit http://www.genome.jp/dbget-bin/www_bget?ko:K00413 Q9D0M3 967 2.8e-103 Cytochrome c1, heme protein, mitochondrial OS=Mus musculus GN=Cyc1 PE=1 SV=1 PF13442//PF02167//PF00034 Cytochrome C oxidase, cbb3-type, subunit III//Cytochrome C1 family//Cytochrome c GO:0006118 obsolete electron transport GO:0020037//GO:0005488//GO:0009055 heme binding//binding//electron carrier activity -- -- KOG3052 Cytochrome c1 Cluster-8721.1 BF_2 9.21 0.47 1099 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8729.0 BF_2 1.00 1.09 314 699667905 XP_009883999.1 220 6.3e-16 PREDICTED: uncharacterized protein LOC104287046, partial [Charadrius vociferus] 42794112 AC137993.2 311 1.68361e-160 Oryza sativa Japonica Group chromosome 11 clone OSJNBb0122P24, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8731.0 BF_2 31.00 1.10 1468 270007845 EFA04293.1 905 1.1e-94 hypothetical protein TcasGA2_TC014584 [Tribolium castaneum] -- -- -- -- -- K09036 MAFB transcription factor MAFB http://www.genome.jp/dbget-bin/www_bget?ko:K09036 O57342 256 8.1e-21 Transcription factor MafA OS=Coturnix coturnix japonica GN=MAFA PE=1 SV=1 PF04977//PF04999//PF03131//PF07716//PF00170 Septum formation initiator//Cell division protein FtsL//bZIP Maf transcription factor//Basic region leucine zipper//bZIP transcription factor GO:0051301//GO:0006355//GO:0007049 cell division//regulation of transcription, DNA-templated//cell cycle GO:0003677//GO:0043565//GO:0003700 DNA binding//sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005634//GO:0016021//GO:0005667 nucleus//integral component of membrane//transcription factor complex -- -- Cluster-8736.1 BF_2 14.00 0.69 1138 795247650 XP_011854309.1 1620 1.0e-177 PREDICTED: keratin, type I cytoskeletal 17 [Mandrillus leucophaeus] 197383031 NM_000422.2 1111 0 Homo sapiens keratin 17, type I (KRT17), mRNA K07604 KRT1 type I keratin, acidic http://www.genome.jp/dbget-bin/www_bget?ko:K07604 Q04695 1630 3.0e-180 Keratin, type I cytoskeletal 17 OS=Homo sapiens GN=KRT17 PE=1 SV=2 PF03836//PF05791//PF00445//PF10186//PF08702//PF00038 RasGAP C-terminus//Bacillus haemolytic enterotoxin (HBL)//Ribonuclease T2 family//Vacuolar sorting 38 and autophagy-related subunit 14//Fibrinogen alpha/beta chain family//Intermediate filament protein GO:0051258//GO:0009405//GO:0007165//GO:0007264//GO:0010508//GO:0030168 protein polymerization//pathogenesis//signal transduction//small GTPase mediated signal transduction//positive regulation of autophagy//platelet activation GO:0033897//GO:0005198//GO:0003723//GO:0005096//GO:0030674//GO:0005102 ribonuclease T2 activity//structural molecule activity//RNA binding//GTPase activator activity//protein binding, bridging//receptor binding GO:0005882//GO:0005577//GO:0016020 intermediate filament//fibrinogen complex//membrane -- -- Cluster-8738.0 BF_2 5.00 2.98 353 -- -- -- -- -- 325197269 AC242017.2 241 1.56845e-121 Homo sapiens FOSMID clone ABC14-987205L11 from chromosome 1, complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8740.0 BF_2 39.00 5.05 610 213512148 NP_001134061.1 373 2.2e-33 Photosystem II 10 kDa polypeptide, chloroplast [Salmo salar]>gi|209730436|gb|ACI66087.1| Photosystem II 10 kDa polypeptide, chloroplast precursor [Salmo salar] 402765834 NM_001248513.2 191 1.75977e-93 Glycine max uncharacterized LOC100499745 (LOC100499745), mRNA -- -- -- -- Q40519 536 1.1e-53 Photosystem II 10 kDa polypeptide, chloroplastic OS=Nicotiana tabacum GN=PSBR PE=2 SV=1 PF04725 Photosystem II 10 kDa polypeptide PsbR GO:0015979 photosynthesis -- -- GO:0042651//GO:0009654//GO:0034357//GO:0009523 thylakoid membrane//photosystem II oxygen evolving complex//photosynthetic membrane//photosystem II -- -- Cluster-8743.0 BF_2 2.00 0.32 549 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8748.0 BF_2 2.00 0.49 456 820994313 XP_012363754.1 425 1.6e-39 PREDICTED: tubulin alpha-1 chain-like isoform X1 [Nomascus leucogenys] 158259730 AK289354.1 456 0 Homo sapiens cDNA FLJ78587 complete cds K07374 TUBA tubulin alpha http://www.genome.jp/dbget-bin/www_bget?ko:K07374 P05213 425 6.4e-41 Tubulin alpha-1B chain OS=Mus musculus GN=Tuba1b PE=1 SV=2 -- -- -- -- -- -- -- -- KOG1376 Alpha tubulin Cluster-8749.0 BF_2 2.00 0.41 493 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8751.0 BF_2 15.00 3.17 485 426366410 XP_004050251.1 505 8.7e-49 PREDICTED: fibroblast growth factor receptor 2 isoform 1 [Gorilla gorilla gorilla] 254553324 NG_012449.1 485 0 Homo sapiens fibroblast growth factor receptor 2 (FGFR2), RefSeqGene on chromosome 10 K05093 FGFR2 fibroblast growth factor receptor 2 http://www.genome.jp/dbget-bin/www_bget?ko:K05093 P21802 472 2.4e-46 Fibroblast growth factor receptor 2 OS=Homo sapiens GN=FGFR2 PE=1 SV=1 PF13895 Immunoglobulin domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-8754.0 BF_2 4.00 0.54 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8756.0 BF_2 2.00 0.54 443 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8761.0 BF_2 3.00 0.49 543 478253942 ENN74234.1 385 8.0e-35 hypothetical protein YQE_09207, partial [Dendroctonus ponderosae]>gi|546674851|gb|ERL86137.1| hypothetical protein D910_03550 [Dendroctonus ponderosae] -- -- -- -- -- K04230 GALR1 galanin receptor 1 http://www.genome.jp/dbget-bin/www_bget?ko:K04230 P47211 158 6.9e-10 Galanin receptor type 1 OS=Homo sapiens GN=GALR1 PE=1 SV=3 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186 G-protein coupled receptor signaling pathway GO:0004930 G-protein coupled receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8761.1 BF_2 9.67 0.73 840 642910835 XP_008193428.1 934 2.7e-98 PREDICTED: pyroglutamylated RFamide peptide receptor-like [Tribolium castaneum]>gi|270015160|gb|EFA11608.1| hypothetical protein TcasGA2_TC014211 [Tribolium castaneum] 820850728 XM_012487523.1 51 1.64793e-15 PREDICTED: Apis florea pyroglutamylated RFamide peptide receptor-like (LOC100870069), transcript variant X3, mRNA -- -- -- -- P83861 287 1.2e-24 Pyroglutamylated RFamide peptide receptor OS=Mus musculus GN=Qrfpr PE=2 SV=1 PF00001 7 transmembrane receptor (rhodopsin family) GO:0007186//GO:0007187//GO:0007268 G-protein coupled receptor signaling pathway//G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger//synaptic transmission GO:0004930//GO:0004983 G-protein coupled receptor activity//neuropeptide Y receptor activity GO:0016021 integral component of membrane KOG3656 FOG: 7 transmembrane receptor Cluster-8764.0 BF_2 10.00 2.22 475 31753114 AAH53854.1 776 3.2e-80 Unknown (protein for IMAGE:5194336), partial [Homo sapiens]>gi|111494016|gb|AAI11385.1| Unknown (protein for IMAGE:5198300), partial [Homo sapiens] 658013766 XM_008343971.1 283 9.7291e-145 PREDICTED: Malus x domestica chlorophyll a-b binding protein 151, chloroplastic-like (LOC103405001), mRNA -- -- -- -- P27518 817 2.3e-86 Chlorophyll a-b binding protein 151, chloroplastic OS=Gossypium hirsutum GN=CAB-151 PE=2 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8769.0 BF_2 1.00 0.33 414 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8771.0 BF_2 1.00 0.35 406 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8773.0 BF_2 9.00 1.15 615 795638330 XP_011736171.1 229 1.1e-16 PREDICTED: ALK tyrosine kinase receptor [Macaca nemestrina] 221554531 NG_009445.1 615 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 229 4.6e-18 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 PF00629//PF01670 MAM domain, meprin/A5/mu//Glycosyl hydrolase family 12 GO:0005985//GO:0000272//GO:0005982 sucrose metabolic process//polysaccharide catabolic process//starch metabolic process GO:0008810 cellulase activity GO:0016020 membrane -- -- Cluster-8776.0 BF_2 2.00 1.31 346 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8786.0 BF_2 7.00 0.46 918 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8788.0 BF_2 2.00 0.61 424 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8789.0 BF_2 2.00 0.42 488 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8791.0 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8792.0 BF_2 3.00 1.75 355 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8795.0 BF_2 4.00 0.89 475 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF03185 Calcium-activated potassium channel, beta subunit GO:0006813 potassium ion transport GO:0015269 calcium-activated potassium channel activity GO:0016020 membrane -- -- Cluster-8797.0 BF_2 3.00 0.35 641 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00854 POT family GO:0006810 transport GO:0005215 transporter activity GO:0016020 membrane -- -- Cluster-8798.0 BF_2 5.00 3.61 339 724888310 XP_010374558.1 579 1.6e-57 PREDICTED: chlorophyll a-b binding protein of LHCII type 1, partial [Rhinopithecus roxellana] 566173304 XM_002307689.2 225 1.17596e-112 Populus trichocarpa Chlorophyll a-b binding protein 2 (POPTR_0005s26070g) mRNA, complete cds -- -- -- -- P09756 586 1.0e-59 Chlorophyll a-b binding protein 3, chloroplastic OS=Glycine max GN=CAB3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8798.1 BF_2 37.00 2.45 920 724888310 XP_010374558.1 1188 1.0e-127 PREDICTED: chlorophyll a-b binding protein of LHCII type 1, partial [Rhinopithecus roxellana] 2804571 AB006081.1 519 0 Fagus crenata mRNA for chlorophyll a/b-binding protein, complete cds -- -- -- -- P09756 1254 9.6e-137 Chlorophyll a-b binding protein 3, chloroplastic OS=Glycine max GN=CAB3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8801.0 BF_2 1.00 0.35 405 506968313 AGM32500.1 281 6.8e-23 39S ribosomal protein L19 [Coptotermes formosanus] -- -- -- -- -- K02884 RP-L19, MRPL19, rplS large subunit ribosomal protein L19 http://www.genome.jp/dbget-bin/www_bget?ko:K02884 Q9VHN6 189 1.3e-13 39S ribosomal protein L19, mitochondrial OS=Drosophila melanogaster GN=mRpL19 PE=2 SV=1 -- -- -- -- -- -- -- -- KOG1698 Mitochondrial/chloroplast ribosomal protein L19 Cluster-8803.0 BF_2 4.00 0.37 738 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8806.0 BF_2 1.00 0.34 409 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8810.0 BF_2 1.00 0.39 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8814.0 BF_2 4.00 1.49 398 857975288 CEO98669.1 268 2.2e-21 hypothetical protein PBRA_006783 [Plasmodiophora brassicae] 702371444 XM_010063419.1 190 4.01198e-93 PREDICTED: Eucalyptus grandis low-temperature-induced cysteine proteinase (LOC104449302), mRNA K01368 CTSS cathepsin S http://www.genome.jp/dbget-bin/www_bget?ko:K01368 P25776 468 5.7e-46 Oryzain alpha chain OS=Oryza sativa subsp. japonica GN=Os04g0650000 PE=1 SV=2 PF03051//PF00112 Peptidase C1-like family//Papain family cysteine protease GO:0006508 proteolysis GO:0004197//GO:0008234 cysteine-type endopeptidase activity//cysteine-type peptidase activity -- -- -- -- Cluster-8816.1 BF_2 8.00 0.35 1231 -- -- -- -- -- 462390244 APGK01018882.1 34 6.8936e-06 Dendroctonus ponderosae Seq01018892, whole genome shotgun sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8826.0 BF_2 4.00 0.53 603 -- -- -- -- -- 528540458 AP012528.1 600 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C -- -- -- -- P46773 923 1.5e-98 Ribosomal protein S3, mitochondrial OS=Oryza sativa subsp. japonica GN=RPS3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8827.0 BF_2 9.00 0.93 691 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8828.0 BF_2 13.00 1.82 586 501673528 YP_007890811.1 371 3.6e-33 ribosomal protein L2 (mitochondrion) [Seculamonas ecuadoriensis]>gi|462269920|gb|AGH24506.1| ribosomal protein L2 (mitochondrion) [Seculamonas ecuadoriensis] 528540458 AP012528.1 580 0 Oryza rufipogon mitochondrial DNA, complete genome, strain: RT102C K02886 RP-L2, MRPL2, rplB large subunit ribosomal protein L2 http://www.genome.jp/dbget-bin/www_bget?ko:K02886 Q2F969 850 4.3e-90 60S ribosomal protein L2, mitochondrial OS=Oryza sativa subsp. indica GN=RPL2 PE=3 SV=2 PF03947 Ribosomal Proteins L2, C-terminal domain GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG2309 60s ribosomal protein L2/L8 Cluster-8832.0 BF_2 2.00 1.19 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8838.0 BF_2 3.00 1.84 351 119592868 EAW72462.1 201 1.1e-13 hCG2042299, partial [Homo sapiens] 18921231 AC084016.12 271 3.27975e-138 Homo sapiens 3 BAC RP11-190F16 (Roswell Park Cancer Institute Human BAC Library) complete sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8840.0 BF_2 2.00 0.45 471 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8841.0 BF_2 4.00 0.92 468 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01407 Geminivirus AL3 protein GO:0016032 viral process -- -- -- -- -- -- Cluster-8842.0 BF_2 8.00 5.53 342 401411409 XP_003885152.1 245 8.6e-19 Heat shock protein 70 (Precursor), related [Neospora caninum Liverpool]>gi|325119571|emb|CBZ55124.1| Heat shock protein 70 (Precursor), related [Neospora caninum Liverpool]>gi|820694110|tpe|CEL69850.1| TPA: Heat shock protein 70 (Precursor), related [Neospora caninum Liverpool] 169244452 EU267978.1 342 1.08315e-177 Oryza sativa Japonica Group clone KCS290E01 dnak-type molecular chaperone Bip mRNA, complete cds K09490 HSPA5, BIP heat shock 70kDa protein 5 http://www.genome.jp/dbget-bin/www_bget?ko:K09490 O24581 343 1.5e-31 Luminal-binding protein 3 OS=Zea mays GN=BIPE3 PE=2 SV=1 PF07851//PF07778//PF07989//PF10459//PF03480//PF10394//PF07499 TMPIT-like protein//Mis6//Centrosomin N-terminal motif 1//Peptidase S46//Bacterial extracellular solute-binding protein, family 7//Histone acetyl transferase HAT1 N-terminus//RuvA, C-terminal domain GO:0016568//GO:0042967//GO:0006810//GO:0034508//GO:0006281//GO:0006310 chromatin modification//acyl-carrier-protein biosynthetic process//transport//centromere complex assembly//DNA repair//DNA recombination GO:0070009//GO:0005524//GO:0008239//GO:0009378//GO:0004402 serine-type aminopeptidase activity//ATP binding//dipeptidyl-peptidase activity//four-way junction helicase activity//histone acetyltransferase activity GO:0016021//GO:0005815//GO:0009379//GO:0000776//GO:0000123//GO:0030288//GO:0005657 integral component of membrane//microtubule organizing center//Holliday junction helicase complex//kinetochore//histone acetyltransferase complex//outer membrane-bounded periplasmic space//replication fork KOG0100 Molecular chaperones GRP78/BiP/KAR2, HSP70 superfamily Cluster-8843.0 BF_2 1.00 0.77 335 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8845.0 BF_2 3.00 0.46 562 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00816 H-NS histone family GO:0006355 regulation of transcription, DNA-templated GO:0003677 DNA binding GO:0005622 intracellular -- -- Cluster-8848.0 BF_2 5.00 0.77 558 -- -- -- -- -- 659114207 XM_008458730.1 92 1.73046e-38 PREDICTED: Cucumis melo probable chalcone--flavonone isomerase 3 (LOC103496746), mRNA -- -- -- -- Q8VZW3 348 6.6e-32 Probable chalcone--flavonone isomerase 3 OS=Arabidopsis thaliana GN=CHI3 PE=1 SV=1 PF02431 Chalcone-flavanone isomerase -- -- GO:0016872 intramolecular lyase activity -- -- -- -- Cluster-8850.0 BF_2 1.00 0.38 395 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8852.0 BF_2 2.00 3.83 287 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8854.0 BF_2 3.89 0.56 575 91079364 XP_970368.1 229 1.0e-16 PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917122|ref|XP_008191123.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|642917124|ref|XP_008191125.1| PREDICTED: vacuolar protein sorting-associated protein 8 homolog [Tribolium castaneum]>gi|270004364|gb|EFA00812.1| hypothetical protein TcasGA2_TC003699 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8856.0 BF_2 7.00 0.97 589 470426331 XP_004337885.1 677 1.2e-68 ubiquitinconjugating enzyme E2, putative [Acanthamoeba castellanii str. Neff]>gi|440794717|gb|ELR15872.1| ubiquitinconjugating enzyme E2, putative [Acanthamoeba castellanii str. Neff] 802735174 XM_012231383.1 333 1.95867e-172 PREDICTED: Jatropha curcas ubiquitin-conjugating enzyme E2 28 (LOC105645712), mRNA K06689 UBE2D_E, UBC4, UBC5 ubiquitin-conjugating enzyme E2 D/E http://www.genome.jp/dbget-bin/www_bget?ko:K06689 P35135 782 3.3e-82 Ubiquitin-conjugating enzyme E2-17 kDa OS=Solanum lycopersicum PE=2 SV=1 PF05743//PF05773 UEV domain//RWD domain GO:0006464//GO:0015031 cellular protein modification process//protein transport GO:0005515 protein binding -- -- KOG0417 Ubiquitin-protein ligase Cluster-8857.1 BF_2 5.00 0.46 740 17391477 AAH18671.1 1223 7.3e-132 Annexin A5 [Homo sapiens]>gi|649117450|gb|AIC54009.1| ANXA5, partial [synthetic construct] 649098448 KJ890676.1 740 0 Synthetic construct Homo sapiens clone ccsbBroadEn_00070 ANXA5 gene, encodes complete protein K16646 ANXA5 annexin A5 http://www.genome.jp/dbget-bin/www_bget?ko:K16646 Q5R1W0 1223 3.0e-133 Annexin A5 OS=Pan troglodytes GN=ANXA5 PE=2 SV=3 PF00191 Annexin -- -- GO:0005509//GO:0005544 calcium ion binding//calcium-dependent phospholipid binding -- -- -- -- Cluster-8858.0 BF_2 8.00 106.94 226 -- -- -- -- -- 584458492 NG_033929.1 226 2.07355e-113 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8862.0 BF_2 1.00 2.59 275 -- -- -- -- -- 520999024 CP003969.1 178 1.24636e-86 Sorangium cellulosum So0157-2, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8864.0 BF_2 18.00 1.44 810 296204918 XP_002749534.1 657 3.4e-66 PREDICTED: 40S ribosomal protein S4, X isoform-like [Callithrix jacchus] 115443688 NM_001052159.1 810 0 Oryza sativa Japonica Group Os02g0105900 (Os02g0105900) mRNA, complete cds K02987 RP-S4e, RPS4 small subunit ribosomal protein S4e http://www.genome.jp/dbget-bin/www_bget?ko:K02987 P49398 898 1.6e-95 40S ribosomal protein S4 OS=Oryza sativa subsp. japonica GN=RPS4 PE=2 SV=3 PF01479 S4 domain -- -- GO:0003723 RNA binding -- -- KOG0378 40S ribosomal protein S4 Cluster-8871.0 BF_2 1.00 0.83 330 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8874.0 BF_2 3.00 3.51 310 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8876.0 BF_2 2.06 0.55 444 546673515 ERL85101.1 353 3.3e-31 hypothetical protein D910_02523 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- Q293C2 223 1.6e-17 Dymeclin OS=Drosophila pseudoobscura pseudoobscura GN=GA20914 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8885.0 BF_2 29.00 2.88 709 521022952 EPQ04740.1 258 5.6e-20 ALK tyrosine kinase receptor [Myotis brandtii] 221554531 NG_009445.1 703 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 233 1.8e-18 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- KOG1095 Protein tyrosine kinase Cluster-8886.0 BF_2 3.00 0.74 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8891.0 BF_2 2.00 0.32 547 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8898.0 BF_2 2.00 0.43 483 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8899.0 BF_2 10.00 1.96 500 116283512 AAH29790.1 299 6.9e-25 Unknown (protein for MGC:35458) [Homo sapiens] 596057897 XM_007220928.1 199 5.09695e-98 Prunus persica hypothetical protein (PRUPE_ppa005158mg) mRNA, complete cds -- -- -- -- Q7X9A0 486 5.9e-48 Ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic OS=Larrea tridentata GN=RCA1 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8899.1 BF_2 60.00 2.65 1236 116283512 AAH29790.1 1475 7.4e-161 Unknown (protein for MGC:35458) [Homo sapiens] 596057897 XM_007220928.1 683 0 Prunus persica hypothetical protein (PRUPE_ppa005158mg) mRNA, complete cds -- -- -- -- Q7X9A0 1709 2.2e-189 Ribulose bisphosphate carboxylase/oxygenase activase 1, chloroplastic OS=Larrea tridentata GN=RCA1 PE=1 SV=1 PF00004//PF06309 ATPase family associated with various cellular activities (AAA)//Torsin -- -- GO:0005524 ATP binding -- -- -- -- Cluster-8901.0 BF_2 1.00 0.31 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00961 LAGLIDADG endonuclease -- -- GO:0004519 endonuclease activity -- -- -- -- Cluster-8903.0 BF_2 12.00 1.19 708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8903.1 BF_2 14.00 1.36 719 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8904.0 BF_2 7.00 0.92 604 -- -- -- -- -- 848857925 XM_012974447.1 182 1.7538e-88 PREDICTED: Erythranthe guttatus protein EXORDIUM-like 3 (LOC105951056), mRNA -- -- -- -- Q9FHM9 534 1.9e-53 Protein EXORDIUM-like 3 OS=Arabidopsis thaliana GN=EXL3 PE=2 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-8907.0 BF_2 2.00 0.68 409 564378864 XP_006249196.1 578 2.5e-57 PREDICTED: eukaryotic translation initiation factor 4H isoform X1 [Rattus norvegicus] 194387307 AK297651.1 409 0 Homo sapiens cDNA FLJ60708 complete cds, highly similar to Eukaryotic translation initiation factor 4H -- -- -- -- Q15056 553 8.1e-56 Eukaryotic translation initiation factor 4H OS=Homo sapiens GN=EIF4H PE=1 SV=5 PF00076 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- KOG0118 FOG: RRM domain Cluster-8908.0 BF_2 3.00 0.34 651 118088890 XP_419936.2 973 6.3e-103 PREDICTED: 40S ribosomal protein S7 isoformX6 [Gallus gallus] 675691884 XM_003807419.2 642 0 PREDICTED: Pan paniscus ribosomal protein S7 (RPS7), transcript variant X2, mRNA K02993 RP-S7e, RPS7 small subunit ribosomal protein S7e http://www.genome.jp/dbget-bin/www_bget?ko:K02993 A6H769 965 2.2e-103 40S ribosomal protein S7 OS=Bos taurus GN=RPS7 PE=2 SV=1 PF01251 Ribosomal protein S7e GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005622//GO:0005840 intracellular//ribosome KOG3320 40S ribosomal protein S7 Cluster-8910.0 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00283 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits GO:0015979 photosynthesis -- -- -- -- -- -- Cluster-8914.0 BF_2 7.00 5.05 339 759169497 XP_011375357.1 138 2.2e-06 PREDICTED: discoidin domain-containing receptor 2 [Pteropus vampyrus] 282721095 NG_016290.1 339 4.99049e-176 Homo sapiens discoidin domain receptor tyrosine kinase 2 (DDR2), RefSeqGene on chromosome 1 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8915.0 BF_2 1.00 0.32 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8918.1 BF_2 4.00 5.84 299 625206860 XP_003505997.2 499 2.7e-48 PREDICTED: actin, aortic smooth muscle isoform X1 [Cricetulus griseus]>gi|625283116|ref|XP_007633234.1| PREDICTED: actin, aortic smooth muscle isoform X1 [Cricetulus griseus] 426365472 XM_004049748.1 299 7.4676e-154 PREDICTED: Gorilla gorilla gorilla actin, alpha 2, smooth muscle, aorta, transcript variant 1 (ACTA2), mRNA K12313 ACTA2 actin, aortic smooth muscle http://www.genome.jp/dbget-bin/www_bget?ko:K12313 P62736 442 4.4e-43 Actin, aortic smooth muscle OS=Homo sapiens GN=ACTA2 PE=1 SV=1 -- -- -- -- -- -- -- -- KOG0676 Actin and related proteins Cluster-8920.0 BF_2 12.00 3.43 433 306840 AAA75493.1 341 8.0e-30 HER2 receptor [Homo sapiens] 171906587 NG_007503.1 433 0 Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), RefSeqGene on chromosome 17 K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 P04626 341 3.3e-31 Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens GN=ERBB2 PE=1 SV=1 PF00757 Furin-like cysteine rich region GO:0007169//GO:0006468 transmembrane receptor protein tyrosine kinase signaling pathway//protein phosphorylation GO:0005524//GO:0004714 ATP binding//transmembrane receptor protein tyrosine kinase activity GO:0016020 membrane -- -- Cluster-8921.0 BF_2 2.00 0.62 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8923.0 BF_2 6.00 1.71 433 700354676 XP_009921627.1 256 5.8e-20 PREDICTED: glycine-rich RNA-binding protein GRP1A-like, partial [Haliaeetus albicilla] 219888684 BT056110.1 348 0 Zea mays full-length cDNA clone ZM_BFb0020N13 mRNA, complete cds K13195 CIRBP cold-inducible RNA-binding protein http://www.genome.jp/dbget-bin/www_bget?ko:K13195 P10979 357 4.6e-33 Glycine-rich RNA-binding, abscisic acid-inducible protein OS=Zea mays GN=RAB15 PE=1 SV=1 PF16367//PF00076 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) -- -- GO:0003676 nucleic acid binding -- -- -- -- Cluster-8925.0 BF_2 3.00 0.32 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8926.0 BF_2 9.00 1.41 555 404503298 CCJ09767.1 391 1.7e-35 hypothetical protein, partial [Hirudo medicinalis] -- -- -- -- -- -- -- -- -- Q07469 151 4.6e-09 Bark storage protein A OS=Populus deltoides GN=BSPA PE=2 SV=1 PF01048 Phosphorylase superfamily GO:0009116 nucleoside metabolic process GO:0003824 catalytic activity -- -- -- -- Cluster-8927.0 BF_2 2.00 0.56 436 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8928.0 BF_2 6.00 0.68 658 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8931.0 BF_2 1.00 0.32 417 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8932.0 BF_2 8.00 26.58 266 -- -- -- -- -- 119710194 DQ490951.2 266 1.44629e-135 Zea mays subsp. mays genotype CMS-S mitochondrion, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8933.0 BF_2 4.00 1.66 386 795446451 XP_011886197.1 250 2.6e-19 PREDICTED: LOW QUALITY PROTEIN: putative uncharacterized protein ZNFX1-AS1 [Cercocebus atys] 551890952 HG511414.1 383 0 TPA: Homo sapiens long non-coding RNA OTTHUMT00000106490.1 (ZFAS1 gene), antisense -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8934.0 BF_2 9.00 3.14 406 795638330 XP_011736171.1 265 4.9e-21 PREDICTED: ALK tyrosine kinase receptor [Macaca nemestrina] 221554531 NG_009445.1 403 0 Homo sapiens anaplastic lymphoma receptor tyrosine kinase (ALK), RefSeqGene (LRG_488) on chromosome 2 K05119 ALK anaplastic lymphoma kinase http://www.genome.jp/dbget-bin/www_bget?ko:K05119 Q9UM73 264 2.6e-22 ALK tyrosine kinase receptor OS=Homo sapiens GN=ALK PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-8942.0 BF_2 6.00 1.65 439 221115153 XP_002163471.1 260 2.0e-20 PREDICTED: 60S ribosomal protein L7a-like [Hydra vulgaris] 156765740 AK289125.1 436 0 Oryza sativa Japonica Group cDNA, clone: J090097O19, full insert sequence K02936 RP-L7Ae, RPL7A large subunit ribosomal protein L7Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02936 P35685 361 1.6e-33 60S ribosomal protein L7a OS=Oryza sativa subsp. japonica GN=RPL7A PE=2 SV=1 -- -- -- -- -- -- -- -- KOG3166 60S ribosomal protein L7A Cluster-8943.0 BF_2 6.00 0.36 992 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8944.0 BF_2 8.00 0.47 998 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8947.0 BF_2 14.00 275.13 217 -- -- -- -- -- 391415518 BT067074.2 217 1.99139e-108 Zea mays full-length cDNA clone ZM_BFb0178D15 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8949.0 BF_2 9.00 0.34 1390 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8949.1 BF_2 7.00 0.59 784 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF01754 A20-like zinc finger -- -- GO:0008270//GO:0003677 zinc ion binding//DNA binding -- -- -- -- Cluster-8955.1 BF_2 1.00 0.38 397 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8957.1 BF_2 4.00 0.58 576 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8958.0 BF_2 3.00 0.35 646 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF11770 GRB2-binding adapter (GAPT) -- -- -- -- GO:0016021 integral component of membrane -- -- Cluster-8960.0 BF_2 3.00 0.58 502 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8961.2 BF_2 3.00 0.35 649 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8965.0 BF_2 1.00 0.39 394 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8967.0 BF_2 6.66 0.54 800 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8967.1 BF_2 5.14 0.34 920 768445539 XP_011564676.1 421 9.1e-39 PREDICTED: hrp65 protein-like isoform X1 [Plutella xylostella] -- -- -- -- -- K13219 SFPQ, PSF splicing factor, proline- and glutamine-rich http://www.genome.jp/dbget-bin/www_bget?ko:K13219 Q9U1N0 414 2.4e-39 Hrp65 protein OS=Chironomus tentans GN=HRP65 PE=1 SV=1 PF00076//PF02601 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Exonuclease VII, large subunit GO:0006308 DNA catabolic process GO:0003676//GO:0008855 nucleic acid binding//exodeoxyribonuclease VII activity GO:0009318 exodeoxyribonuclease VII complex KOG0115 RNA-binding protein p54nrb (RRM superfamily) Cluster-8968.0 BF_2 11.00 1.70 558 557124239 CDI78359.1 405 3.9e-37 60s ribosomal protein L33-A, putative [Eimeria acervulina] 209967440 FJ362592.1 215 7.29184e-107 Vernicia fordii 60S ribosomal protein L35a (RPL35A) mRNA, complete cds K02917 RP-L35Ae, RPL35A large subunit ribosomal protein L35Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02917 Q9LMK0 561 1.3e-56 60S ribosomal protein L35a-1 OS=Arabidopsis thaliana GN=RPL35AA PE=3 SV=1 PF01782//PF00813//PF01247 RimM N-terminal domain//FliP family//Ribosomal protein L35Ae GO:0009306//GO:0006412//GO:0006364//GO:0042254 protein secretion//translation//rRNA processing//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622//GO:0016020 ribosome//intracellular//membrane KOG0887 60S ribosomal protein L35A/L37 Cluster-8970.0 BF_2 2.00 0.77 394 545209281 XP_005607641.1 543 2.8e-53 PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X2 [Equus caballus]>gi|664769486|ref|XP_008542291.1| PREDICTED: guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 isoform X1 [Equus przewalskii] 543173165 NM_002074.4 394 0 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1), transcript variant 1, mRNA K04536 GNB1 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 http://www.genome.jp/dbget-bin/www_bget?ko:K04536 P62871 511 5.9e-51 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 OS=Bos taurus GN=GNB1 PE=1 SV=3 PF00400//PF12235//PF02344 WD domain, G-beta repeat//Fragile X-related 1 protein core C terminal//Myc leucine zipper domain GO:0006355 regulation of transcription, DNA-templated GO:0003700//GO:0005515//GO:0003723 transcription factor activity, sequence-specific DNA binding//protein binding//RNA binding GO:0005667//GO:0005634 transcription factor complex//nucleus KOG0286 G-protein beta subunit Cluster-8971.0 BF_2 14.00 1.83 607 -- -- -- -- -- 297724792 NM_001187831.1 299 1.60812e-153 Oryza sativa Japonica Group Os06g0324150 (Os06g0324150) mRNA, complete cds -- -- -- -- Q9LQL2 183 9.8e-13 Protein NRT1/ PTR FAMILY 7.3 OS=Arabidopsis thaliana GN=NPF7.3 PE=1 SV=2 PF03333 Adhesin biosynthesis transcription regulatory protein GO:0006355 regulation of transcription, DNA-templated -- -- -- -- -- -- Cluster-8973.0 BF_2 10.00 2.32 467 -- -- -- -- -- 385718871 JF969237.1 461 0 Oryza sativa clone KCB711H10 Sucrose synthase 2 mRNA, complete cds -- -- -- -- P30298 433 7.7e-42 Sucrose synthase 2 OS=Oryza sativa subsp. japonica GN=SUS2 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-8974.0 BF_2 5.00 1.27 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8976.0 BF_2 3.00 0.45 563 426389328 XP_004061075.1 675 2.0e-68 PREDICTED: uncharacterized protein LOC101150587 [Gorilla gorilla gorilla] 34530243 AK124456.1 563 0 Homo sapiens cDNA FLJ42465 fis, clone BRACE2030096 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8977.0 BF_2 1.00 0.44 380 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8979.0 BF_2 29.00 1.06 1432 642919063 XP_975077.3 677 2.9e-68 PREDICTED: uncharacterized protein LOC663958 [Tribolium castaneum]>gi|270005590|gb|EFA02038.1| hypothetical protein TcasGA2_TC007665 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00069 Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-8981.0 BF_2 2.00 0.79 391 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8983.0 BF_2 8.00 1.82 471 524945510 XP_005073398.1 270 1.5e-21 PREDICTED: proto-oncogene tyrosine-protein kinase ROS [Mesocricetus auratus] 584458492 NG_033929.1 471 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 269 8.0e-23 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 PF07714 Protein tyrosine kinase GO:0006468 protein phosphorylation GO:0004672 protein kinase activity -- -- -- -- Cluster-8984.0 BF_2 10.00 2.22 475 -- -- -- -- -- 238011873 BT086619.1 394 0 Zea mays full-length cDNA clone ZM_BFc0192D13 mRNA, complete cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8989.0 BF_2 5.00 0.39 818 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8992.0 BF_2 19.00 13.71 339 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8993.0 BF_2 7.00 3.15 378 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08036 Diapausin family of antimicrobial peptide GO:0050832 defense response to fungus -- -- GO:0005576 extracellular region -- -- Cluster-8997.0 BF_2 1.00 0.98 320 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-8999.0 BF_2 8.00 4.77 353 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9000.0 BF_2 4.00 0.72 521 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9001.0 BF_2 8.00 0.90 658 700346190 XP_009917077.1 648 3.1e-65 PREDICTED: elongation factor 1-alpha 1, partial [Haliaeetus albicilla] 819320423 KP245811.1 323 7.97666e-167 Betula luminifera elongation factor 1-alpha mRNA, complete cds K03231 EEF1A elongation factor 1-alpha http://www.genome.jp/dbget-bin/www_bget?ko:K03231 O24534 673 1.6e-69 Elongation factor 1-alpha OS=Vicia faba PE=2 SV=1 PF02774 Semialdehyde dehydrogenase, dimerisation domain GO:0008652//GO:0000051//GO:0055114 cellular amino acid biosynthetic process//obsolete urea cycle intermediate metabolic process//oxidation-reduction process GO:0003942//GO:0016620//GO:0046983 N-acetyl-gamma-glutamyl-phosphate reductase activity//oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//protein dimerization activity GO:0005737 cytoplasm KOG0052 Translation elongation factor EF-1 alpha/Tu Cluster-9011.0 BF_2 4.00 1.65 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9014.0 BF_2 3.00 0.47 553 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9017.0 BF_2 12.00 2.17 518 752875466 XP_011255085.1 476 2.1e-45 PREDICTED: glyceraldehyde-3-phosphate dehydrogenase 1-like [Camponotus floridanus]>gi|307181618|gb|EFN69158.1| Glyceraldehyde-3-phosphate dehydrogenase [Camponotus floridanus] 802724160 XM_012230243.1 204 8.7744e-101 PREDICTED: Jatropha curcas glyceraldehyde-3-phosphate dehydrogenase, cytosolic (LOC105644775), mRNA K00134 GAPDH, gapA glyceraldehyde 3-phosphate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00134 P25861 540 3.3e-54 Glyceraldehyde-3-phosphate dehydrogenase, cytosolic OS=Antirrhinum majus GN=GAPC PE=2 SV=1 PF02800 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain GO:0006094//GO:0055114//GO:0006006//GO:0006096 gluconeogenesis//oxidation-reduction process//glucose metabolic process//glycolytic process GO:0016620//GO:0004365//GO:0050661//GO:0051287 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor//glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity//NADP binding//NAD binding -- -- KOG0657 Glyceraldehyde 3-phosphate dehydrogenase Cluster-9018.0 BF_2 2.00 0.65 416 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9020.0 BF_2 5.00 0.39 828 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9029.0 BF_2 3.00 0.32 685 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9030.0 BF_2 5.00 0.81 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9030.2 BF_2 6.00 0.62 695 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9031.0 BF_2 7.00 2.97 384 767943397 XP_011534352.1 255 6.7e-20 PREDICTED: proto-oncogene tyrosine-protein kinase ROS isoform X2 [Homo sapiens] 584458492 NG_033929.1 384 0 Homo sapiens ROS proto-oncogene 1 , receptor tyrosine kinase (ROS1), RefSeqGene on chromosome 6 K05088 ROS1 proto-oncogene tyrosine-protein kinase ROS http://www.genome.jp/dbget-bin/www_bget?ko:K05088 P08922 255 2.7e-21 Proto-oncogene tyrosine-protein kinase ROS OS=Homo sapiens GN=ROS1 PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-9032.0 BF_2 2.00 0.69 408 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9034.0 BF_2 4.00 0.44 665 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9040.0 BF_2 4.00 0.51 613 91082451 XP_971337.1 246 1.2e-18 PREDICTED: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 [Tribolium castaneum]>gi|270007152|gb|EFA03600.1| hypothetical protein TcasGA2_TC013687 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9043.0 BF_2 3.00 0.78 448 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9048.0 BF_2 2.00 0.52 449 239949541 ACS36545.1 476 1.9e-45 troponin C isoform 5 [Homarus americanus] 239949540 FJ790224.1 129 3.71426e-59 Homarus americanus troponin C isoform 5 mRNA, complete cds -- -- -- -- P15159 223 1.7e-17 Troponin C OS=Tachypleus tridentatus PE=1 SV=1 PF13499//PF13833//PF13405//PF00036//PF12763//PF13202 EF-hand domain pair//EF-hand domain pair//EF-hand domain//EF hand//Cytoskeletal-regulatory complex EF hand//EF hand -- -- GO:0005509//GO:0005515 calcium ion binding//protein binding -- -- KOG0027 Calmodulin and related proteins (EF-Hand superfamily) Cluster-9051.0 BF_2 8.00 1.84 469 873233905 CEM02528.1 426 1.2e-39 unnamed protein product [Vitrella brassicaformis CCMP3155] 743909960 XM_011050173.1 164 1.36104e-78 PREDICTED: Populus euphratica cytochrome b6-f complex iron-sulfur subunit, chloroplastic-like (LOC105142513), mRNA -- -- -- -- Q69S39 658 6.3e-68 Cytochrome b6-f complex iron-sulfur subunit, chloroplastic OS=Oryza sativa subsp. japonica GN=petC PE=1 SV=1 PF00355//PF08802 Rieske [2Fe-2S] domain//Cytochrome B6-F complex Fe-S subunit GO:0006118//GO:0055114 obsolete electron transport//oxidation-reduction process GO:0009496//GO:0051537//GO:0016491 plastoquinol--plastocyanin reductase activity//2 iron, 2 sulfur cluster binding//oxidoreductase activity GO:0009512//GO:0042651 cytochrome b6f complex//thylakoid membrane KOG1671 Ubiquinol cytochrome c reductase, subunit RIP1 Cluster-9053.0 BF_2 3.00 0.63 486 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9054.0 BF_2 2.00 0.40 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9057.0 BF_2 7.00 1.92 439 -- -- -- -- -- 396084084 JX089987.1 240 7.15723e-121 Fragaria x ananassa cultivar Benihoppe BHLH domain class transcription factor (BHLH16) mRNA, complete cds -- -- -- -- Q9FH37 400 4.9e-38 Transcription factor ILR3 OS=Arabidopsis thaliana GN=ILR3 PE=1 SV=1 PF07926//PF05529//PF09798//PF04977//PF07851//PF07716//PF05557//PF00769//PF06003//PF10473//PF06005//PF10186//PF16740//PF00170//PF06156//PF04111 TPR/MLP1/MLP2-like protein//B-cell receptor-associated protein 31-like//DNA damage checkpoint protein//Septum formation initiator//TMPIT-like protein//Basic region leucine zipper//Mitotic checkpoint protein//Ezrin/radixin/moesin family//Survival motor neuron protein (SMN)//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Protein of unknown function (DUF904)//Vacuolar sorting 38 and autophagy-related subunit 14//Spindle and kinetochore-associated protein 2//bZIP transcription factor//Protein of unknown function (DUF972)//Autophagy protein Apg6 GO:0000077//GO:0051301//GO:0006260//GO:0006606//GO:0007059//GO:0007049//GO:0010508//GO:0031110//GO:0000090//GO:0007067//GO:0006355//GO:0006886//GO:0006914//GO:0000917//GO:0043093//GO:0007094//GO:0006397 DNA damage checkpoint//cell division//DNA replication//protein import into nucleus//chromosome segregation//cell cycle//positive regulation of autophagy//regulation of microtubule polymerization or depolymerization//mitotic anaphase//mitotic nuclear division//regulation of transcription, DNA-templated//intracellular protein transport//autophagy//barrier septum assembly//FtsZ-dependent cytokinesis//mitotic spindle assembly checkpoint//mRNA processing GO:0003700//GO:0008134//GO:0045502//GO:0008092//GO:0043565//GO:0008017//GO:0042803//GO:0003723 transcription factor activity, sequence-specific DNA binding//transcription factor binding//dynein binding//cytoskeletal protein binding//sequence-specific DNA binding//microtubule binding//protein homodimerization activity//RNA binding GO:0045298//GO:0019898//GO:0005667//GO:0030286//GO:0005876//GO:0005737//GO:0016021//GO:0000940//GO:0005783//GO:0005634 tubulin complex//extrinsic component of membrane//transcription factor complex//dynein complex//spindle microtubule//cytoplasm//integral component of membrane//condensed chromosome outer kinetochore//endoplasmic reticulum//nucleus -- -- Cluster-9058.0 BF_2 2.00 0.39 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9063.0 BF_2 3.00 0.52 528 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9064.0 BF_2 4.00 0.38 724 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9065.0 BF_2 2.00 0.40 497 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9066.0 BF_2 2.00 1.76 326 478250393 ENN70888.1 161 4.5e-09 hypothetical protein YQE_12293, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- PF00731 AIR carboxylase GO:0006189 'de novo' IMP biosynthetic process -- -- -- -- -- -- Cluster-9070.0 BF_2 1.00 1.49 298 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9072.0 BF_2 5.00 0.67 600 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9084.0 BF_2 4.00 0.52 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9090.0 BF_2 2.00 0.34 532 4235275 AAD13152.1 795 2.3e-82 talin [Homo sapiens] 694929918 XM_009456602.1 526 0 PREDICTED: Pan troglodytes talin 1 (TLN1), mRNA K06271 TLN talin http://www.genome.jp/dbget-bin/www_bget?ko:K06271 Q9Y490 789 4.6e-83 Talin-1 OS=Homo sapiens GN=TLN1 PE=1 SV=3 PF01044//PF01608 Vinculin family//I/LWEQ domain GO:0007155 cell adhesion GO:0051015//GO:0003779 actin filament binding//actin binding -- -- -- -- Cluster-9092.0 BF_2 2.00 0.36 522 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9097.0 BF_2 4.00 1.12 436 -- -- -- -- -- 731423156 XM_010664084.1 103 1.02189e-44 PREDICTED: Vitis vinifera glycerophosphodiester phosphodiesterase protein kinase domain-containing GDPDL2-like (LOC100263570), transcript variant X2, mRNA -- -- -- -- Q9FID5 203 3.3e-15 Probable receptor-like protein kinase At5g39030 OS=Arabidopsis thaliana GN=At5g39030 PE=2 SV=1 PF07714//PF00069 Protein tyrosine kinase//Protein kinase domain GO:0006468 protein phosphorylation GO:0005524//GO:0004672 ATP binding//protein kinase activity -- -- -- -- Cluster-9099.0 BF_2 1.00 15.15 223 297263209 XP_002798784.1 370 1.8e-33 PREDICTED: hypothetical protein LOC100428622 [Macaca mulatta] 164691068 AK315826.1 223 9.49809e-112 Homo sapiens cDNA, FLJ79475 complete cds, highly similar to Keratin, type II cytoskeletal 8 K07605 KRT2 type II keratin, basic http://www.genome.jp/dbget-bin/www_bget?ko:K07605 P05787 361 8.2e-34 Keratin, type II cytoskeletal 8 OS=Homo sapiens GN=KRT8 PE=1 SV=7 PF07926//PF01496//PF00038 TPR/MLP1/MLP2-like protein//V-type ATPase 116kDa subunit family//Intermediate filament protein GO:0015992//GO:0015991//GO:0006606 proton transport//ATP hydrolysis coupled proton transport//protein import into nucleus GO:0005198//GO:0015078 structural molecule activity//hydrogen ion transmembrane transporter activity GO:0005882//GO:0033179 intermediate filament//proton-transporting V-type ATPase, V0 domain -- -- Cluster-9099.1 BF_2 5.00 0.51 697 181573 AAA35763.1 818 6.4e-85 cytokeratin 8 [Homo sapiens] 694950031 XM_009425352.1 535 0 PREDICTED: Pan troglodytes keratin 8 (KRT8), mRNA K07605 KRT2 type II keratin, basic http://www.genome.jp/dbget-bin/www_bget?ko:K07605 P05787 818 2.6e-86 Keratin, type II cytoskeletal 8 OS=Homo sapiens GN=KRT8 PE=1 SV=7 PF08074//PF08702//PF00769//PF00038//PF07926//PF10473//PF07328//PF04111 CHDCT2 (NUC038) domain//Fibrinogen alpha/beta chain family//Ezrin/radixin/moesin family//Intermediate filament protein//TPR/MLP1/MLP2-like protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//T-DNA border endonuclease VirD1//Autophagy protein Apg6 GO:0030168//GO:0006355//GO:0006606//GO:0006914//GO:0051258//GO:0007165 platelet activation//regulation of transcription, DNA-templated//protein import into nucleus//autophagy//protein polymerization//signal transduction GO:0030674//GO:0042803//GO:0008092//GO:0004519//GO:0003677//GO:0016818//GO:0008270//GO:0005102//GO:0005198//GO:0045502//GO:0008134//GO:0005524 protein binding, bridging//protein homodimerization activity//cytoskeletal protein binding//endonuclease activity//DNA binding//hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides//zinc ion binding//receptor binding//structural molecule activity//dynein binding//transcription factor binding//ATP binding GO:0005667//GO:0005634//GO:0030286//GO:0005577//GO:0005737//GO:0005882//GO:0019898 transcription factor complex//nucleus//dynein complex//fibrinogen complex//cytoplasm//intermediate filament//extrinsic component of membrane -- -- Cluster-9099.2 BF_2 7.00 0.56 814 181573 AAA35763.1 761 3.0e-78 cytokeratin 8 [Homo sapiens] 372466576 NM_001256293.1 814 0 Homo sapiens keratin 8, type II (KRT8), transcript variant 3, mRNA K07605 KRT2 type II keratin, basic http://www.genome.jp/dbget-bin/www_bget?ko:K07605 P05787 761 1.2e-79 Keratin, type II cytoskeletal 8 OS=Homo sapiens GN=KRT8 PE=1 SV=7 PF07820//PF04111//PF02482//PF10473//PF06810//PF15003//PF13851//PF10392//PF05529//PF01496//PF04632//PF04977//PF06009//PF16326//PF16331//PF02601//PF00038//PF04513//PF02185//PF07926//PF11427//PF05837//PF07989 TraC-like protein//Autophagy protein Apg6//Sigma 54 modulation protein / S30EA ribosomal protein//Leucine-rich repeats of kinetochore protein Cenp-F/LEK1//Phage minor structural protein GP20//HAUS augmin-like complex subunit 2//Growth-arrest specific micro-tubule binding//Golgi transport complex subunit 5//B-cell receptor-associated protein 31-like//V-type ATPase 116kDa subunit family//Fusaric acid resistance protein family//Septum formation initiator//Laminin Domain II//ABC transporter C-terminal domain//TolA binding protein trimerisation//Exonuclease VII, large subunit//Intermediate filament protein//Baculovirus polyhedron envelope protein, PEP, C terminus//Hr1 repeat//TPR/MLP1/MLP2-like protein//Tc3 transposase//Centromere protein H (CENP-H)//Centrosomin N-terminal motif 1 GO:0048870//GO:0006891//GO:0051225//GO:0031023//GO:0051382//GO:0015992//GO:0006606//GO:0015991//GO:0006308//GO:0000746//GO:0007155//GO:0006886//GO:0070206//GO:0006810//GO:0006914//GO:0007165//GO:0007049//GO:0044238 cell motility//intra-Golgi vesicle-mediated transport//spindle assembly//microtubule organizing center organization//kinetochore assembly//proton transport//protein import into nucleus//ATP hydrolysis coupled proton transport//DNA catabolic process//conjugation//cell adhesion//intracellular protein transport//protein trimerization//transport//autophagy//signal transduction//cell cycle//primary metabolic process GO:0008134//GO:0045502//GO:0008855//GO:0003677//GO:0042803//GO:0005198//GO:0015078 transcription factor binding//dynein binding//exodeoxyribonuclease VII activity//DNA binding//protein homodimerization activity//structural molecule activity//hydrogen ion transmembrane transporter activity GO:0005667//GO:0030286//GO:0000776//GO:0005882//GO:0019028//GO:0009318//GO:0019031//GO:0005783//GO:0005886//GO:0033179//GO:0017119//GO:0031514//GO:0005815//GO:0016021 transcription factor complex//dynein complex//kinetochore//intermediate filament//viral capsid//exodeoxyribonuclease VII complex//viral envelope//endoplasmic reticulum//plasma membrane//proton-transporting V-type ATPase, V0 domain//Golgi transport complex//motile cilium//microtubule organizing center//integral component of membrane -- -- Cluster-9101.0 BF_2 7.00 1.50 482 -- -- -- -- -- 802755899 XM_012233556.1 297 1.63057e-152 PREDICTED: Jatropha curcas protein DEHYDRATION-INDUCED 19 homolog 3 (LOC105647455), mRNA -- -- -- -- Q84J70 426 5.1e-41 Protein DEHYDRATION-INDUCED 19 homolog 3 OS=Arabidopsis thaliana GN=DI19-3 PE=1 SV=1 PF13465 Zinc-finger double domain -- -- GO:0046872 metal ion binding -- -- -- -- Cluster-9106.0 BF_2 3.00 0.38 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9108.0 BF_2 9.00 1.16 613 754342595 XP_004366029.2 558 7.8e-55 catalase isozyme 2 [Capsaspora owczarzaki ATCC 30864] 357966937 JN831452.1 311 3.468e-160 Ziziphus jujuba catalase mRNA, complete cds K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 O24339 903 3.2e-96 Catalase OS=Soldanella alpina PE=2 SV=1 PF00199 Catalase GO:0006568//GO:0015947//GO:0006979//GO:0055114//GO:0006804 tryptophan metabolic process//methane metabolic process//response to oxidative stress//oxidation-reduction process//obsolete peroxidase reaction GO:0004096//GO:0020037 catalase activity//heme binding -- -- KOG0047 Catalase Cluster-9108.1 BF_2 35.00 1.55 1230 308480591 XP_003102502.1 541 1.5e-52 CRE-CTL-3 protein [Caenorhabditis remanei]>gi|308261234|gb|EFP05187.1| CRE-CTL-3 protein [Caenorhabditis remanei] 731427402 XM_010665664.1 423 0 PREDICTED: Vitis vinifera catalase isozyme 1 (LOC100244516), mRNA K03781 katE, CAT, catB, srpA catalase http://www.genome.jp/dbget-bin/www_bget?ko:K03781 P49317 1225 3.0e-133 Catalase isozyme 3 OS=Nicotiana plumbaginifolia GN=CAT3 PE=2 SV=1 PF00199 Catalase GO:0006804//GO:0055114//GO:0006979//GO:0015947//GO:0006568 obsolete peroxidase reaction//oxidation-reduction process//response to oxidative stress//methane metabolic process//tryptophan metabolic process GO:0020037//GO:0004096 heme binding//catalase activity -- -- KOG0047 Catalase Cluster-9109.1 BF_2 2.00 0.42 484 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9111.0 BF_2 2.00 0.46 469 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9116.0 BF_2 10.00 4.04 389 608785535 AHW56604.1 605 1.8e-60 v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2 isoform B, partial [Homo sapiens] 54888662 CR626867.6 389 0 Human DNA sequence from clone XX-HCC1954_8J23, complete sequence K05083 ERBB2, HER2 receptor tyrosine-protein kinase erbB-2 http://www.genome.jp/dbget-bin/www_bget?ko:K05083 P04626 517 1.2e-51 Receptor tyrosine-protein kinase erbB-2 OS=Homo sapiens GN=ERBB2 PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9119.0 BF_2 3.00 0.75 455 -- -- -- -- -- 695032669 XM_009405615.1 40 1.12439e-09 PREDICTED: Musa acuminata subsp. malaccensis dehydrin Xero 1-like (LOC103987340), mRNA -- -- -- -- Q9XJ56 139 9.2e-08 Phosphoprotein ECPP44 OS=Daucus carota GN=ECPP44 PE=1 SV=1 PF04119//PF00257 Heat shock protein 9/12//Dehydrin GO:0009415//GO:0006950 response to water//response to stress -- -- -- -- -- -- Cluster-9121.0 BF_2 25.00 55.37 281 -- -- -- -- -- 21871 X13914.1 95 1.76087e-40 Wheat signal recognition particle (SRP) 7S RNA variant 2 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9122.0 BF_2 5.00 0.54 674 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9126.0 BF_2 6.00 0.90 565 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9134.0 BF_2 2.00 0.98 370 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9136.0 BF_2 2.00 21.86 231 -- -- -- -- -- 12331122 AL391872.7 176 1.32621e-85 Human DNA sequence from clone RP11-87M1 on chromosome 9, complete sequence -- -- -- -- -- -- -- -- PF01754 A20-like zinc finger -- -- GO:0003677//GO:0008270 DNA binding//zinc ion binding -- -- -- -- Cluster-9138.0 BF_2 7.00 0.57 798 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9140.0 BF_2 1.00 0.34 410 767953210 XP_011515432.1 563 1.4e-55 PREDICTED: plectin isoform X2 [Homo sapiens] 767953223 XM_011517132.1 410 0 PREDICTED: Homo sapiens plectin (PLEC), transcript variant X14, mRNA K10388 PLEC plectin http://www.genome.jp/dbget-bin/www_bget?ko:K10388 Q15149 563 5.7e-57 Plectin OS=Homo sapiens GN=PLEC PE=1 SV=3 -- -- -- -- -- -- -- -- -- -- Cluster-9141.0 BF_2 8.00 0.79 709 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9144.0 BF_2 9.00 1.54 532 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9145.0 BF_2 1.00 0.34 411 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9146.0 BF_2 2.00 1.71 328 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9147.0 BF_2 2.00 1.63 331 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9153.0 BF_2 2.00 0.57 434 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9155.0 BF_2 3.00 0.64 482 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9156.0 BF_2 7.00 2.97 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9159.0 BF_2 10.00 0.58 1003 301500958 YP_003795423.1 890 4.1e-93 photosystem I P700 chlorophyll a apoprotein A2 [Alveolata sp. CCMP3155]>gi|300069504|gb|ADJ66611.1| photosystem I P700 chlorophyll a apoprotein A2 (chloroplast) [Chromerida sp. RM11] 808178593 KP760075.1 928 0 Prunus subhirtella var. subhirtella isolate 2014-P2 chloroplast, complete genome -- -- -- -- Q68S07 1336 3.2e-146 Photosystem I P700 chlorophyll a apoprotein A2 OS=Panax ginseng GN=psaB PE=3 SV=1 PF00223 Photosystem I psaA/psaB protein GO:0015979 photosynthesis -- -- GO:0009579//GO:0009522//GO:0016021//GO:0044424 thylakoid//photosystem I//integral component of membrane//intracellular part -- -- Cluster-9159.1 BF_2 61.00 0.57 4793 115443557 YP_778576.1 3116 0.0e+00 P700 apoprotein subunit Ia [Bigelowiella natans]>gi|115443566|ref|YP_778585.1| P700 apoprotein subunit Ia [Bigelowiella natans]>gi|122246279|sp|Q06J42.1|PSAA_BIGNA RecName: Full=Photosystem I P700 chlorophyll a apoprotein A1; AltName: Full=PSI-A; AltName: Full=PsaA (chloroplast) [Bigelowiella natans]>gi|110810202|gb|ABG91408.1| P700 apoprotein subunit Ia [Bigelowiella natans]>gi|110810211|gb|ABG91417.1| P700 apoprotein subunit Ia [Bigelowiella natans] 353685124 JN861110.1 4506 0 Oryza sativa Indica Group chloroplast, complete genome -- -- -- -- Q0ZJ20 3883 0.0e+00 Photosystem I P700 chlorophyll a apoprotein A1 OS=Vitis vinifera GN=psaA PE=3 SV=1 PF08052//PF00223 PyrBI operon leader peptide//Photosystem I psaA/psaB protein GO:0015979//GO:0018298//GO:0022900//GO:0019856 photosynthesis//protein-chromophore linkage//electron transport chain//pyrimidine nucleobase biosynthetic process GO:0016168//GO:0016491//GO:0046872//GO:0051539 chlorophyll binding//oxidoreductase activity//metal ion binding//4 iron, 4 sulfur cluster binding GO:0016021//GO:0009522//GO:0009579//GO:0009535 integral component of membrane//photosystem I//thylakoid//chloroplast thylakoid membrane -- -- Cluster-9165.0 BF_2 2.00 0.68 410 357615390 EHJ69628.1 147 2.4e-07 hypothetical protein KGM_14968 [Danaus plexippus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9166.0 BF_2 3.00 2.88 321 -- -- -- -- -- 645234569 XM_008225648.1 152 4.21252e-72 PREDICTED: Prunus mume transcription factor bHLH35 (LOC103323643), mRNA -- -- -- -- Q2HIV9 295 5.3e-26 Transcription factor bHLH35 OS=Arabidopsis thaliana GN=BHLH35 PE=2 SV=1 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) -- -- Cluster-9168.0 BF_2 8.00 1.39 528 470249525 XP_004366994.1 348 1.5e-30 cytosolic glycoprotein FP21 [Dictyostelium fasciculatum]>gi|328871641|gb|EGG20011.1| cytosolic glycoprotein FP21 [Dictyostelium fasciculatum] 595808031 XM_007202646.1 201 4.16668e-99 Prunus persica hypothetical protein (PRUPE_ppa012752mg) mRNA, complete cds K03094 SKP1, CBF3D S-phase kinase-associated protein 1 http://www.genome.jp/dbget-bin/www_bget?ko:K03094 Q39255 441 1.0e-42 SKP1-like protein 1A OS=Arabidopsis thaliana GN=SKP1A PE=1 SV=1 PF04121//PF01466//PF03931 Nuclear pore protein 84 / 107//Skp1 family, dimerisation domain//Skp1 family, tetramerisation domain GO:0006810//GO:0006511 transport//ubiquitin-dependent protein catabolic process -- -- GO:0005643 nuclear pore KOG1724 SCF ubiquitin ligase, Skp1 component Cluster-9170.0 BF_2 2.00 0.38 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9171.0 BF_2 10.00 4.36 381 795335989 XP_011928920.1 215 2.9e-15 PREDICTED: mast/stem cell growth factor receptor Kit isoform X3 [Cercocebus atys] 170014706 NG_007456.1 381 0 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), RefSeqGene (LRG_307) on chromosome 4 K05091 KIT, SCFR proto-oncogene tyrosine-protein kinase Kit http://www.genome.jp/dbget-bin/www_bget?ko:K05091 P10721 215 1.2e-16 Mast/stem cell growth factor receptor Kit OS=Homo sapiens GN=KIT PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9175.0 BF_2 3.00 0.42 589 -- -- -- -- -- 761231605 KM881639.1 589 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9177.0 BF_2 9.42 0.64 905 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9179.1 BF_2 4.00 0.76 508 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9180.0 BF_2 22.53 0.90 1334 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15168//PF13404 Triple QxxK/R motif-containing protein family//AsnC-type helix-turn-helix domain GO:0006355 regulation of transcription, DNA-templated GO:0043565 sequence-specific DNA binding GO:0005789 endoplasmic reticulum membrane -- -- Cluster-9183.0 BF_2 4.00 1.29 416 -- -- -- -- -- 743905228 XM_011047710.1 113 2.6812e-50 PREDICTED: Populus euphratica mechanosensitive ion channel protein 10-like (LOC105140746), mRNA -- -- -- -- -- -- -- -- PF06596 Photosystem II reaction centre X protein (PsbX) GO:0015979 photosynthesis -- -- GO:0016020//GO:0009523 membrane//photosystem II -- -- Cluster-9186.0 BF_2 8.00 1.33 539 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9188.0 BF_2 5.00 0.64 615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9189.0 BF_2 3.00 0.55 515 861622409 KMQ87739.1 478 1.2e-45 hypothetical protein RF55_12895 [Lasius niger] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9193.0 BF_2 2.00 0.33 538 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9195.0 BF_2 2.00 0.34 534 569379971 ETO14807.1 527 2.7e-51 enolase 2 [Reticulomyxa filosa] 764638308 XM_004308115.2 256 1.12383e-129 PREDICTED: Fragaria vesca subsp. vesca enolase (LOC101291767), mRNA K01689 ENO, eno enolase http://www.genome.jp/dbget-bin/www_bget?ko:K01689 Q42971 586 1.6e-59 Enolase OS=Oryza sativa subsp. japonica GN=ENO1 PE=1 SV=2 PF00113 Enolase, C-terminal TIM barrel domain GO:0000162//GO:0006571//GO:0009094//GO:0006094//GO:0006096 tryptophan biosynthetic process//tyrosine biosynthetic process//L-phenylalanine biosynthetic process//gluconeogenesis//glycolytic process GO:0000287//GO:0004634 magnesium ion binding//phosphopyruvate hydratase activity GO:0000015 phosphopyruvate hydratase complex KOG2670 Enolase Cluster-9198.0 BF_2 2.00 0.39 499 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9201.0 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9203.0 BF_2 10.00 2.06 490 -- -- -- -- -- 119395201 EF122475.1 490 0 Oryza sativa (japonica cultivar-group) clone KCS336G08 calcium-dependent protein kinase mRNA, complete cds -- -- -- -- P53682 347 7.6e-32 Calcium-dependent protein kinase isoform 1 OS=Oryza sativa subsp. japonica GN=SPK PE=2 SV=2 PF13499//PF00036//PF01719//PF13405//PF13833//PF12763//PF13202 EF-hand domain pair//EF hand//Plasmid replication protein//EF-hand domain//EF-hand domain pair//Cytoskeletal-regulatory complex EF hand//EF hand GO:0006265//GO:0006260 DNA topological change//DNA replication GO:0003916//GO:0005515//GO:0005509//GO:0003677 DNA topoisomerase activity//protein binding//calcium ion binding//DNA binding GO:0005727 extrachromosomal circular DNA -- -- Cluster-9205.0 BF_2 1.00 0.31 422 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9208.0 BF_2 3.00 0.40 597 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9211.0 BF_2 7.00 0.92 607 857978167 CEO96142.1 565 1.2e-55 hypothetical protein PBRA_004832 [Plasmodiophora brassicae] 115465470 NM_001062870.1 541 0 Oryza sativa Japonica Group Os05g0565000 (Os05g0565000) mRNA, complete cds K02882 RP-L18Ae, RPL18A large subunit ribosomal protein L18Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02882 Q943F3 918 5.8e-98 60S ribosomal protein L18a OS=Oryza sativa subsp. japonica GN=RPL18A PE=2 SV=1 PF01775//PF12539 Ribosomal L18ae/LX protein domain//Chromosome segregation protein Csm1/Pcs1 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735//GO:0005515 structural constituent of ribosome//protein binding GO:0005840 ribosome KOG0829 60S ribosomal protein L18A Cluster-9213.0 BF_2 3.00 0.58 502 675706185 XP_009007421.1 608 1.0e-60 PREDICTED: 40S ribosomal protein S20, partial [Callithrix jacchus] 226246668 NM_001023.3 502 0 Homo sapiens ribosomal protein S20 (RPS20), transcript variant 2, mRNA K02969 RP-S20e, RPS20 small subunit ribosomal protein S20e http://www.genome.jp/dbget-bin/www_bget?ko:K02969 Q4R5D0 605 9.4e-62 40S ribosomal protein S20 OS=Macaca fascicularis GN=RPS20 PE=3 SV=1 -- -- -- -- -- -- -- -- KOG0900 40S ribosomal protein S20 Cluster-9217.0 BF_2 9.85 1.51 561 196020247 XP_002119097.1 174 2.4e-10 hypothetical protein TRIADDRAFT_35144 [Trichoplax adhaerens]>gi|190576971|gb|EDV18417.1| hypothetical protein TRIADDRAFT_35144 [Trichoplax adhaerens] 761231605 KM881639.1 399 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q95H63 344 1.9e-31 30S ribosomal protein S16, chloroplastic OS=Triticum aestivum GN=rps16 PE=3 SV=1 PF00886 Ribosomal protein S16 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-9218.0 BF_2 5.00 1.59 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9219.0 BF_2 1.04 0.45 382 546686193 ERL95573.1 254 8.7e-20 hypothetical protein D910_12834 [Dendroctonus ponderosae] -- -- -- -- -- K00109 E1.1.99.2 2-hydroxyglutarate dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00109 Q9H9P8 221 2.4e-17 L-2-hydroxyglutarate dehydrogenase, mitochondrial OS=Homo sapiens GN=L2HGDH PE=1 SV=3 -- -- -- -- -- -- -- -- KOG2665 Predicted FAD-dependent oxidoreductase Cluster-9221.0 BF_2 5.00 0.92 515 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9228.0 BF_2 2.00 0.54 441 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9231.0 BF_2 5.00 0.33 912 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9232.0 BF_2 5.00 1.25 454 -- -- -- -- -- 761231940 KM881643.1 454 0 Oryza officinalis chloroplast, complete genome -- -- -- -- Q6ENC8 491 1.4e-48 50S ribosomal protein L23, chloroplastic OS=Oryza nivara GN=rpl23-A PE=3 SV=1 PF00276 Ribosomal protein L23 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome -- -- Cluster-9238.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9239.0 BF_2 2.00 0.83 386 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9242.0 BF_2 11.00 0.64 1009 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9247.0 BF_2 3.00 0.95 418 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9258.0 BF_2 7.00 2.18 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9259.0 BF_2 11.00 5.82 363 817286132 XP_012313338.1 224 2.5e-16 PREDICTED: hamartin [Aotus nancymaae]>gi|817286134|ref|XP_012313339.1| PREDICTED: hamartin [Aotus nancymaae]>gi|817286136|ref|XP_012313340.1| PREDICTED: hamartin [Aotus nancymaae]>gi|817286138|ref|XP_012313341.1| PREDICTED: hamartin [Aotus nancymaae]>gi|817286140|ref|XP_012313342.1| PREDICTED: hamartin [Aotus nancymaae]>gi|817286142|ref|XP_012313343.1| PREDICTED: hamartin [Aotus nancymaae] 254039583 NG_012386.1 363 0 Homo sapiens tuberous sclerosis 1 (TSC1), RefSeqGene (LRG_486) on chromosome 9 K07206 TSC1 tuberous sclerosis 1 http://www.genome.jp/dbget-bin/www_bget?ko:K07206 Q92574 214 1.5e-16 Hamartin OS=Homo sapiens GN=TSC1 PE=1 SV=2 PF01399 PCI domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-9271.0 BF_2 7.00 0.33 1181 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9274.0 BF_2 10.00 0.63 949 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02272//PF01607 DHHA1 domain//Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061//GO:0003676 chitin binding//nucleic acid binding GO:0005576 extracellular region -- -- Cluster-9277.0 BF_2 34.00 0.59 2708 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9288.0 BF_2 3.00 0.54 519 -- -- -- -- -- 636591374 XM_008028835.1 339 7.90729e-176 Setosphaeria turcica Et28A hypothetical protein partial mRNA -- -- -- -- F2QY27 657 9.1e-68 Alcohol oxidase 1 OS=Komagataella pastoris (strain ATCC 76273 / CBS 7435 / CECT 11047 / NRRL Y-11430 / Wegner 21-1) GN=AOX1 PE=1 SV=1 PF05199 GMC oxidoreductase GO:0055114 oxidation-reduction process GO:0016614 oxidoreductase activity, acting on CH-OH group of donors -- -- -- -- Cluster-9294.0 BF_2 7.00 0.36 1103 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9294.2 BF_2 1.00 0.42 384 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9304.0 BF_2 2.00 0.37 511 240104633 3HOF 605 2.3e-60 Chain A, Structure Of Macrophage Migration Inhibitory Factor (Mif) With Caffeic Acid At 1.9a Resolution>gi|240104634|pdb|3HOF|B Chain B, Structure Of Macrophage Migration Inhibitory Factor (Mif) With Caffeic Acid At 1.9a Resolution>gi|240104635|pdb|3HOF|C Chain C, Structure Of Macrophage Migration Inhibitory Factor (Mif) With Caffeic Acid At 1.9a Resolution 4505184 NM_002415.1 511 0 Homo sapiens macrophage migration inhibitory factor (glycosylation-inhibiting factor) (MIF), mRNA K07253 MIF phenylpyruvate tautomerase http://www.genome.jp/dbget-bin/www_bget?ko:K07253 Q4R549 604 1.3e-61 Macrophage migration inhibitory factor OS=Macaca fascicularis GN=MIF PE=3 SV=3 PF01344 Kelch motif GO:0050731//GO:0030890//GO:0050715//GO:0050918//GO:0006954//GO:0045087//GO:0007166//GO:0071157//GO:0033138//GO:0010739//GO:0043030//GO:0010629//GO:0001516//GO:0070207//GO:0048146//GO:0043066//GO:0043518//GO:0006558//GO:0090344//GO:0006570//GO:0070374//GO:0007165 positive regulation of peptidyl-tyrosine phosphorylation//positive regulation of B cell proliferation//positive regulation of cytokine secretion//positive chemotaxis//inflammatory response//innate immune response//cell surface receptor signaling pathway//negative regulation of cell cycle arrest//positive regulation of peptidyl-serine phosphorylation//positive regulation of protein kinase A signaling//regulation of macrophage activation//negative regulation of gene expression//prostaglandin biosynthetic process//protein homotrimerization//positive regulation of fibroblast proliferation//negative regulation of apoptotic process//negative regulation of DNA damage response, signal transduction by p53 class mediator//L-phenylalanine metabolic process//negative regulation of cell aging//tyrosine metabolic process//positive regulation of ERK1 and ERK2 cascade//signal transduction GO:0050178//GO:0005125//GO:0005126//GO:0042056//GO:0005515//GO:0043498//GO:0004167 phenylpyruvate tautomerase activity//cytokine activity//cytokine receptor binding//chemoattractant activity//protein binding//obsolete cell surface binding//dopachrome isomerase activity GO:0009986//GO:0005615//GO:0005737 cell surface//extracellular space//cytoplasm KOG1759 Macrophage migration inhibitory factor Cluster-9305.0 BF_2 3.00 0.31 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00366 Ribosomal protein S17 GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular -- -- Cluster-9314.0 BF_2 2.00 1.60 332 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9326.0 BF_2 3.00 0.63 487 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9329.0 BF_2 2.00 0.51 451 642913508 XP_008201043.1 291 5.3e-24 PREDICTED: corticotropin-releasing factor-binding protein isoform X2 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- P24387 122 8.6e-06 Corticotropin-releasing factor-binding protein OS=Homo sapiens GN=CRHBP PE=1 SV=2 PF05428 Corticotropin-releasing factor binding protein (CRF-BP) -- -- GO:0051424 corticotropin-releasing hormone binding -- -- -- -- Cluster-9330.0 BF_2 3.00 0.34 654 189236533 XP_975493.2 500 4.5e-48 PREDICTED: triosephosphate isomerase [Tribolium castaneum]>gi|270005300|gb|EFA01748.1| hypothetical protein TcasGA2_TC007346 [Tribolium castaneum] -- -- -- -- -- K01803 TPI, tpiA triosephosphate isomerase (TIM) http://www.genome.jp/dbget-bin/www_bget?ko:K01803 B0BM40 486 7.7e-48 Triosephosphate isomerase OS=Xenopus tropicalis GN=tpi1 PE=2 SV=1 PF00121//PF06883 Triosephosphate isomerase//RNA polymerase I, Rpa2 specific domain GO:0006351//GO:0006096//GO:0008152//GO:0006144//GO:0006020//GO:0006094//GO:0015976//GO:0006206//GO:0006013//GO:0006000//GO:0046486 transcription, DNA-templated//glycolytic process//metabolic process//purine nucleobase metabolic process//inositol metabolic process//gluconeogenesis//carbon utilization//pyrimidine nucleobase metabolic process//mannose metabolic process//fructose metabolic process//glycerolipid metabolic process GO:0003899//GO:0004807 DNA-directed RNA polymerase activity//triose-phosphate isomerase activity GO:0005634//GO:0005730 nucleus//nucleolus KOG1643 Triosephosphate isomerase Cluster-9331.0 BF_2 2.00 0.73 400 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9332.0 BF_2 10.00 1.29 611 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9341.0 BF_2 77.00 6.34 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9362.0 BF_2 15.62 0.45 1744 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9370.0 BF_2 3.00 6.02 285 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9371.1 BF_2 2.00 0.61 423 308051574 ADO00265.1 270 1.3e-21 SIFamide [Cancer borealis] 308051573 GU016327.1 238 8.89359e-120 Cancer borealis SIFamide mRNA, complete cds -- -- -- -- Q867W1 217 7.7e-17 FMRFamide-related neuropeptides OS=Procambarus clarkii PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9371.2 BF_2 5.00 1.55 421 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9371.3 BF_2 1.00 0.47 373 -- -- -- -- -- 299800932 GU327660.1 80 5.26269e-32 Portunus trituberculatus microsatellite Ptri_10 sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9372.0 BF_2 3.00 0.41 593 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9377.0 BF_2 1.00 0.39 392 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9378.0 BF_2 2.00 0.37 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF06449 Mitochondrial domain of unknown function (DUF1082) -- -- GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016021//GO:0005739 integral component of membrane//mitochondrion -- -- Cluster-9380.0 BF_2 2.84 0.40 587 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9382.0 BF_2 7.00 0.68 718 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9384.0 BF_2 4.00 0.65 546 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9385.0 BF_2 19.52 0.63 1577 642938411 XP_008191057.1 1051 1.4e-111 PREDICTED: uncharacterized MFS-type transporter C09D4.1 [Tribolium castaneum] -- -- -- -- -- K08220 FLVCR, SLC49A1_2 MFS transporter, FLVCR family, feline leukemia virus subgroup C receptor-related protein http://www.genome.jp/dbget-bin/www_bget?ko:K08220 Q9Y5Y0 660 1.2e-67 Feline leukemia virus subgroup C receptor-related protein 1 OS=Homo sapiens GN=FLVCR1 PE=1 SV=1 PF07690//PF03137//PF04153 Major Facilitator Superfamily//Organic Anion Transporter Polypeptide (OATP) family//NOT2 / NOT3 / NOT5 family GO:0006810//GO:0006355//GO:0055085 transport//regulation of transcription, DNA-templated//transmembrane transport GO:0005215 transporter activity GO:0005634//GO:0016021//GO:0016020 nucleus//integral component of membrane//membrane KOG2563 Permease of the major facilitator superfamily Cluster-9386.0 BF_2 9.00 0.93 694 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF13971 Meiosis-specific protein Mei4 GO:0042138//GO:0006310 meiotic DNA double-strand break formation//DNA recombination -- -- -- -- -- -- Cluster-9387.0 BF_2 2.00 0.81 389 241095555 XP_002409523.1 221 5.9e-16 cytochrome C oxidase subunit VIc [Ixodes scapularis]>gi|67083993|gb|AAY66931.1| cytochrome c oxidase subunit VIc [Ixodes scapularis]>gi|215492766|gb|EEC02407.1| cytochrome C oxidase subunit VIc [Ixodes scapularis] -- -- -- -- -- K02268 COX6C cytochrome c oxidase subunit 6c http://www.genome.jp/dbget-bin/www_bget?ko:K02268 P80977 158 4.9e-10 Cytochrome c oxidase subunit 6C-1 OS=Thunnus obesus PE=1 SV=2 -- -- -- -- GO:0016491 oxidoreductase activity -- -- -- -- Cluster-9404.0 BF_2 105.00 3.72 1469 752880987 XP_011258078.1 601 1.9e-59 PREDICTED: lipase 3-like [Camponotus floridanus]>gi|307178434|gb|EFN67149.1| Lipase 3 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- Q8K2A6 439 4.9e-42 Lipase member M OS=Mus musculus GN=Lipm PE=2 SV=1 PF04083//PF01738 Partial alpha/beta-hydrolase lipase region//Dienelactone hydrolase family GO:0006629 lipid metabolic process GO:0016787 hydrolase activity -- -- KOG2624 Triglyceride lipase-cholesterol esterase Cluster-9410.0 BF_2 7.00 0.64 746 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9411.0 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9418.0 BF_2 11.00 1.57 581 300678088 ADK27312.1 218 2.0e-15 C-type lectin [Procambarus clarkii] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9422.0 BF_2 9.00 1.29 580 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00947 Picornavirus core protein 2A GO:0016032//GO:0006508 viral process//proteolysis GO:0008233 peptidase activity -- -- -- -- Cluster-9428.0 BF_2 1.00 0.32 419 675385067 KFM77964.1 372 2.0e-33 Dual specificity protein phosphatase 8, partial [Stegodyphus mimosarum] -- -- -- -- -- K04459 DUSP, MKP dual specificity MAP kinase phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K04459 Q9BY84 317 1.9e-28 Dual specificity protein phosphatase 16 OS=Homo sapiens GN=DUSP16 PE=1 SV=1 PF00782//PF00102 Dual specificity phosphatase, catalytic domain//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004725//GO:0008138 protein tyrosine phosphatase activity//protein tyrosine/serine/threonine phosphatase activity -- -- KOG1716 Dual specificity phosphatase Cluster-9436.0 BF_2 2.00 0.47 466 646715520 KDR19097.1 329 2.1e-28 FYVE, RhoGEF and PH domain-containing protein 6 [Zootermopsis nevadensis] -- -- -- -- -- K05724 FGD5_6 FYVE, RhoGEF and PH domain containing 5/6 http://www.genome.jp/dbget-bin/www_bget?ko:K05724 Q6ZV73 232 1.6e-18 FYVE, RhoGEF and PH domain-containing protein 6 OS=Homo sapiens GN=FGD6 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-9437.0 BF_2 3.00 0.37 625 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9445.0 BF_2 11.00 0.44 1327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9446.0 BF_2 2.00 0.33 539 588294489 AHK23026.1 390 2.1e-35 beta-1,3-glucan-binding protein precursor [Astacus astacus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9447.0 BF_2 3.00 0.36 639 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9453.1 BF_2 2.00 0.31 559 478256751 ENN76932.1 379 4.1e-34 hypothetical protein YQE_06579, partial [Dendroctonus ponderosae]>gi|546679208|gb|ERL89702.1| hypothetical protein D910_07065 [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9455.0 BF_2 2.00 0.36 519 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9462.0 BF_2 35.00 1.48 1274 478252687 ENN73083.1 1145 1.4e-122 hypothetical protein YQE_10287, partial [Dendroctonus ponderosae]>gi|546682847|gb|ERL92736.1| hypothetical protein D910_10046 [Dendroctonus ponderosae] 657738924 XM_008333177.1 138 1.09775e-63 PREDICTED: Cynoglossus semilaevis forkhead box protein D3-like (LOC103395457), mRNA K09397 FOXD forkhead box protein D http://www.genome.jp/dbget-bin/www_bget?ko:K09397 Q5M7L9 570 2.7e-57 Forkhead box protein D3 OS=Xenopus tropicalis GN=foxd3 PE=2 SV=1 PF00250 Forkhead domain GO:0006355 regulation of transcription, DNA-templated GO:0043565//GO:0003700 sequence-specific DNA binding//transcription factor activity, sequence-specific DNA binding GO:0005667 transcription factor complex KOG2294 Transcription factor of the Forkhead/HNF3 family Cluster-9467.0 BF_2 3.00 0.43 582 675390066 KFM82963.1 669 1.0e-67 60S ribosomal protein L12, partial [Stegodyphus mimosarum] -- -- -- -- -- K02870 RP-L12e, RPL12 large subunit ribosomal protein L12e http://www.genome.jp/dbget-bin/www_bget?ko:K02870 P61865 652 3.9e-67 60S ribosomal protein L12 OS=Caenorhabditis briggsae GN=rpl-12 PE=3 SV=1 PF00298 Ribosomal protein L11, RNA binding domain GO:0006412//GO:0042254 translation//ribosome biogenesis GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG0886 40S ribosomal protein S2 Cluster-9468.0 BF_2 2.00 0.55 439 -- -- -- -- -- -- -- -- -- -- -- -- -- -- P79017 442 6.5e-43 Major allergen Asp f 2 OS=Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) GN=AFUA_4G09580 PE=1 SV=2 -- -- -- -- -- -- -- -- -- -- Cluster-9471.0 BF_2 5.00 0.38 834 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9475.0 BF_2 80.35 1.18 3143 300394168 ADK11710.1 621 2.0e-61 aminopeptidase N [Leptinotarsa decemlineata] -- -- -- -- -- -- -- -- -- O57579 431 8.9e-41 Aminopeptidase N OS=Gallus gallus GN=ANPEP PE=1 SV=1 PF00342//PF02990//PF01433 Phosphoglucose isomerase//Endomembrane protein 70//Peptidase family M1 GO:0006094//GO:0005982//GO:0006098//GO:0006096//GO:0005985 gluconeogenesis//starch metabolic process//pentose-phosphate shunt//glycolytic process//sucrose metabolic process GO:0004347//GO:0008270//GO:0008237 glucose-6-phosphate isomerase activity//zinc ion binding//metallopeptidase activity GO:0016021 integral component of membrane -- -- Cluster-9476.0 BF_2 2.00 1.07 362 75029794 Q4PM12.1 415 1.8e-38 RecName: Full=60S ribosomal protein L36 [Ixodes scapularis]>gi|67084037|gb|AAY66953.1| ribosomal protein L36 [Ixodes scapularis] -- -- -- -- -- K02920 RP-L36e, RPL36 large subunit ribosomal protein L36e http://www.genome.jp/dbget-bin/www_bget?ko:K02920 Q4PM12 415 7.3e-40 60S ribosomal protein L36 OS=Ixodes scapularis GN=RpL36 PE=3 SV=1 PF01158 Ribosomal protein L36e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3452 60S ribosomal protein L36 Cluster-9477.0 BF_2 5.00 0.40 812 397522646 XP_003831370.1 1128 8.4e-121 PREDICTED: 60S ribosomal protein L7 isoform X1 [Pan paniscus]>gi|119607405|gb|EAW86999.1| ribosomal protein L7, isoform CRA_a [Homo sapiens]>gi|119607406|gb|EAW87000.1| ribosomal protein L7, isoform CRA_a [Homo sapiens] 426359903 XM_004047148.1 743 0 PREDICTED: Gorilla gorilla gorilla ribosomal protein L7, transcript variant 1 (RPL7), mRNA K02937 RP-L7e, RPL7 large subunit ribosomal protein L7e http://www.genome.jp/dbget-bin/www_bget?ko:K02937 Q5R9R4 1123 1.3e-121 60S ribosomal protein L7 OS=Pongo abelii GN=RPL7 PE=2 SV=1 -- -- GO:0000184//GO:0006414//GO:0006614//GO:0019083//GO:0042254//GO:0042273//GO:0006415//GO:0006413//GO:0006364 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay//translational elongation//SRP-dependent cotranslational protein targeting to membrane//viral transcription//ribosome biogenesis//ribosomal large subunit biogenesis//translational termination//translational initiation//rRNA processing GO:0003677//GO:0003729//GO:0042803//GO:0003735 DNA binding//mRNA binding//protein homodimerization activity//structural constituent of ribosome GO:0022625//GO:0005840 cytosolic large ribosomal subunit//ribosome -- -- Cluster-9479.0 BF_2 1.00 0.65 347 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9480.1 BF_2 4.00 0.36 750 -- -- -- -- -- 761231605 KM881639.1 750 0 Oryza glaberrima isolate 101328 chloroplast, complete genome -- -- -- -- Q6ENH3 152 4.7e-09 Photosystem I assembly protein Ycf3 OS=Oryza nivara GN=ycf3 PE=3 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9493.0 BF_2 3.00 2.60 327 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9496.0 BF_2 11.00 1.22 663 470323642 XP_004349545.1 309 6.3e-26 glutathione transferase [Capsaspora owczarzaki ATCC 30864]>gi|765551074|gb|KJE91695.1| glutathione transferase [Capsaspora owczarzaki ATCC 30864] -- -- -- -- -- -- -- -- -- P46423 524 3.1e-52 Glutathione S-transferase OS=Hyoscyamus muticus PE=1 SV=1 PF02798 Glutathione S-transferase, N-terminal domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-9500.1 BF_2 6.02 0.34 1029 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9511.0 BF_2 2.00 0.57 434 478260020 ENN79809.1 135 6.2e-06 hypothetical protein YQE_03750, partial [Dendroctonus ponderosae] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9516.0 BF_2 28.26 0.89 1615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9522.0 BF_2 6.00 1.73 432 89258153 ABD65299.1 175 1.4e-10 ENSANGP00000021035-like [Litopenaeus vannamei] -- -- -- -- -- -- -- -- -- -- -- -- -- PF01607 Chitin binding Peritrophin-A domain GO:0006030 chitin metabolic process GO:0008061 chitin binding GO:0005576 extracellular region -- -- Cluster-9530.0 BF_2 1.00 0.35 405 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9535.0 BF_2 2.00 3.57 290 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9537.0 BF_2 3.00 0.35 647 -- -- -- -- -- 262401397 FJ774881.1 106 3.33989e-46 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9539.0 BF_2 3.00 0.49 543 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9548.0 BF_2 2.00 0.82 387 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9552.0 BF_2 5.00 1.79 403 675384628 KFM77525.1 495 1.0e-47 60S ribosomal protein L31, partial [Stegodyphus mimosarum] -- -- -- -- -- K02910 RP-L31e, RPL31 large subunit ribosomal protein L31e http://www.genome.jp/dbget-bin/www_bget?ko:K02910 Q7KF90 483 1.1e-47 60S ribosomal protein L31 OS=Spodoptera frugiperda GN=RpL31 PE=2 SV=1 PF03852//PF01198 DNA mismatch endonuclease Vsr//Ribosomal protein L31e GO:0006412//GO:0042254//GO:0006298 translation//ribosome biogenesis//mismatch repair GO:0003735//GO:0004519 structural constituent of ribosome//endonuclease activity GO:0005622//GO:0005840 intracellular//ribosome KOG0893 60S ribosomal protein L31 Cluster-9559.0 BF_2 4.00 0.44 669 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9563.0 BF_2 7.00 0.54 827 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9571.0 BF_2 3.00 0.54 518 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF08052 PyrBI operon leader peptide GO:0019856 pyrimidine nucleobase biosynthetic process -- -- -- -- -- -- Cluster-9574.0 BF_2 6.00 0.88 572 307193893 EFN76504.1 142 1.3e-06 Histone-lysine N-methyltransferase SETMAR, partial [Harpegnathos saltator] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9583.0 BF_2 2.00 0.33 542 857970642 CEP03007.1 315 1.0e-26 hypothetical protein PBRA_009225 [Plasmodiophora brassicae] 697090708 XM_009659931.1 515 0 Verticillium dahliae VdLs.17 60S ribosomal protein L43 mRNA K02921 RP-L37Ae, RPL37A large subunit ribosomal protein L37Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02921 Q751L1 302 1.4e-26 60S ribosomal protein L43 OS=Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056) GN=RPL43 PE=3 SV=1 PF01780 Ribosomal L37ae protein family GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG0402 60S ribosomal protein L37 Cluster-9601.0 BF_2 11.00 0.67 970 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9606.0 BF_2 2.00 0.40 496 762079669 XP_011412976.1 300 5.3e-25 PREDICTED: abnormal spindle-like microcephaly-associated protein homolog isoform X7 [Crassostrea gigas] -- -- -- -- -- -- -- -- -- -- -- -- -- PF07464//PF00612//PF07820 Apolipophorin-III precursor (apoLp-III)//IQ calmodulin-binding motif//TraC-like protein GO:0006869//GO:0000746 lipid transport//conjugation GO:0008289//GO:0005515 lipid binding//protein binding GO:0005576 extracellular region -- -- Cluster-9613.0 BF_2 15.00 1.74 648 318087202 ADV40193.1 694 1.4e-70 60S ribosomal protein l17 [Latrodectus hesperus] 829792087 XM_012769901.1 67 1.60111e-24 PREDICTED: Microcebus murinus ribosomal protein L17 (RPL17), mRNA K02880 RP-L17e, RPL17 large subunit ribosomal protein L17e http://www.genome.jp/dbget-bin/www_bget?ko:K02880 Q09JW2 685 6.4e-71 60S ribosomal protein L17 OS=Argas monolakensis GN=RpL17 PE=2 SV=1 PF00237 Ribosomal protein L22p/L17e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG3353 60S ribosomal protein L22 Cluster-9614.1 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9616.0 BF_2 2.00 0.31 558 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9619.0 BF_2 1.00 0.45 377 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9626.0 BF_2 1.00 0.36 401 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9644.0 BF_2 8.00 0.33 1293 328796228 AEB40303.1 408 4.1e-37 mitochondrial ATP synthase delta subunit precursor [Litopenaeus vannamei] -- -- -- -- -- K02134 ATPeF1D, ATP5D, ATP16 F-type H+-transporting ATPase subunit delta http://www.genome.jp/dbget-bin/www_bget?ko:K02134 P05630 244 1.8e-19 ATP synthase subunit delta, mitochondrial OS=Bos taurus GN=ATP5D PE=1 SV=2 PF02823 ATP synthase, Delta/Epsilon chain, beta-sandwich domain GO:0015992//GO:0006119//GO:0015986 proton transport//oxidative phosphorylation//ATP synthesis coupled proton transport GO:0046961//GO:0046933 proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism GO:0045259//GO:0045261 proton-transporting ATP synthase complex//proton-transporting ATP synthase complex, catalytic core F(1) KOG1758 Mitochondrial F1F0-ATP synthase, subunit delta/ATP16 Cluster-9649.0 BF_2 1.00 0.65 346 752861962 XP_011260215.1 217 1.5e-15 PREDICTED: uncharacterized protein LOC105253711 [Camponotus floridanus]>gi|752861964|ref|XP_011260225.1| PREDICTED: uncharacterized protein LOC105253711 [Camponotus floridanus]>gi|752861966|ref|XP_011260233.1| PREDICTED: uncharacterized protein LOC105253711 [Camponotus floridanus]>gi|307189888|gb|EFN74132.1| hypothetical protein EAG_07940 [Camponotus floridanus] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9651.0 BF_2 3.00 0.39 606 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9652.0 BF_2 5.00 0.68 594 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9657.0 BF_2 3.00 0.31 689 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9660.0 BF_2 3.00 0.48 551 768408631 XP_011548416.1 313 1.8e-26 PREDICTED: gamma-aminobutyric acid type B receptor subunit 2, partial [Plutella xylostella] 194916197 XM_001982934.1 53 8.17147e-17 Drosophila erecta GG11045 (Dere\GG11045), mRNA K04615 GABBR gamma-aminobutyric acid type B receptor http://www.genome.jp/dbget-bin/www_bget?ko:K04615 -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9681.0 BF_2 4.00 0.44 667 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9685.0 BF_2 3.00 1.00 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9689.0 BF_2 1.00 2.88 271 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF04689//PF11857//PF01484 DNA binding protein S1FA//Domain of unknown function (DUF3377)//Nematode cuticle collagen N-terminal domain GO:0006355 regulation of transcription, DNA-templated GO:0004222//GO:0003677//GO:0042302 metalloendopeptidase activity//DNA binding//structural constituent of cuticle GO:0005634 nucleus -- -- Cluster-9690.0 BF_2 2.00 0.37 512 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9698.0 BF_2 10.00 0.65 930 262401219 ACY66512.1 277 4.6e-22 hypothetical protein [Scylla paramamosain] 262401218 FJ774791.1 520 0 Scylla paramamosain hypothetical protein mRNA, partial cds -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9700.0 BF_2 4.00 0.69 531 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00460 Flagella basal body rod protein GO:0071973 bacterial-type flagellum-dependent cell motility -- -- -- -- -- -- Cluster-9701.0 BF_2 59.00 4.86 795 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9711.0 BF_2 4.00 0.31 823 -- -- -- -- -- 338224430 HM217860.1 39 7.55864e-09 Scylla paramamosain isolate 2 polyprotein-like mRNA, partial sequence -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9714.0 BF_2 5.00 0.82 542 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9716.0 BF_2 3.00 0.59 501 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9717.0 BF_2 8.00 0.66 793 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9718.0 BF_2 56.00 3.07 1049 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9718.2 BF_2 52.00 1.69 1572 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9718.3 BF_2 49.00 1.75 1457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF00680 RNA dependent RNA polymerase GO:0006351//GO:0006144 transcription, DNA-templated//purine nucleobase metabolic process GO:0003723//GO:0003968 RNA binding//RNA-directed RNA polymerase activity GO:0031379 RNA-directed RNA polymerase complex -- -- Cluster-9719.0 BF_2 5.00 0.37 849 871271169 XP_005111157.2 384 1.6e-34 PREDICTED: RNA-binding protein cabeza-like isoform X3 [Aplysia californica] -- -- -- -- -- K13098 TLS, FUS RNA-binding protein FUS http://www.genome.jp/dbget-bin/www_bget?ko:K13098 Q27294 315 6.7e-28 RNA-binding protein cabeza OS=Drosophila melanogaster GN=caz PE=2 SV=2 PF16367//PF00076//PF00641 RNA recognition motif//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)//Zn-finger in Ran binding protein and others -- -- GO:0008270//GO:0003676 zinc ion binding//nucleic acid binding -- -- KOG1995 Conserved Zn-finger protein Cluster-9736.0 BF_2 10.00 1.04 688 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9742.0 BF_2 2.00 0.42 488 676458395 XP_009054961.1 163 4.0e-09 hypothetical protein LOTGIDRAFT_71188, partial [Lottia gigantea]>gi|556105644|gb|ESO94296.1| hypothetical protein LOTGIDRAFT_71188, partial [Lottia gigantea] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9747.0 BF_2 15.00 1.81 633 850297539 XP_012861397.1 334 7.6e-29 PREDICTED: smoothened homolog [Echinops telfairi] 4324953 AF114821.1 633 0 HSSMO3 Homo sapiens smoothened (SMO) gene, exons 3 through 12 and complete cds K06226 SMO smoothened http://www.genome.jp/dbget-bin/www_bget?ko:K06226 Q99835 334 3.1e-30 Smoothened homolog OS=Homo sapiens GN=SMO PE=1 SV=1 PF01534 Frizzled/Smoothened family membrane region GO:0007166 cell surface receptor signaling pathway -- -- GO:0016020 membrane -- -- Cluster-9748.0 BF_2 1.00 1.59 295 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9752.0 BF_2 11.98 0.76 946 642927632 XP_008195342.1 514 1.5e-49 PREDICTED: dual specificity protein phosphatase 23-like isoform X1 [Tribolium castaneum] -- -- -- -- -- K14165 K14165 atypical dual specificity phosphatase http://www.genome.jp/dbget-bin/www_bget?ko:K14165 Q9BVJ7 315 7.5e-28 Dual specificity protein phosphatase 23 OS=Homo sapiens GN=DUSP23 PE=1 SV=1 PF00782//PF05706//PF00102 Dual specificity phosphatase, catalytic domain//Cyclin-dependent kinase inhibitor 3 (CDKN3)//Protein-tyrosine phosphatase GO:0006570//GO:0006470 tyrosine metabolic process//protein dephosphorylation GO:0004721//GO:0008138//GO:0004725 phosphoprotein phosphatase activity//protein tyrosine/serine/threonine phosphatase activity//protein tyrosine phosphatase activity -- -- -- -- Cluster-9754.0 BF_2 46.00 0.84 2582 115443540 YP_778559.1 1640 1.1e-179 ATP synthase CF1 alpha chain [Bigelowiella natans]>gi|122233797|sp|Q06J68.1|ATPA_BIGNA RecName: Full=ATP synthase subunit alpha, chloroplastic; AltName: Full=ATP synthase F1 sector subunit alpha; AltName: Full=F-ATPase subunit alpha (chloroplast) [Bigelowiella natans]>gi|110810185|gb|ABG91391.1| ATP synthase CF1 alpha chain [Bigelowiella natans] 761231605 KM881639.1 2579 0 Oryza glaberrima isolate 101328 chloroplast, complete genome K02132 ATPeF1A, ATP5A1, ATP1 F-type H+-transporting ATPase subunit alpha http://www.genome.jp/dbget-bin/www_bget?ko:K02132 Q09G61 2137 1.1e-238 ATP synthase subunit alpha, chloroplastic OS=Platanus occidentalis GN=atpA PE=3 SV=1 PF00006//PF00430//PF00306//PF02874 ATP synthase alpha/beta family, nucleotide-binding domain//ATP synthase B/B' CF(0)//ATP synthase alpha/beta chain, C terminal domain//ATP synthase alpha/beta family, beta-barrel domain GO:0015992//GO:0046034//GO:0015986//GO:0015991//GO:0006119 proton transport//ATP metabolic process//ATP synthesis coupled proton transport//ATP hydrolysis coupled proton transport//oxidative phosphorylation GO:0015078//GO:0046961//GO:0046933//GO:0005524//GO:0016820 hydrogen ion transmembrane transporter activity//proton-transporting ATPase activity, rotational mechanism//proton-transporting ATP synthase activity, rotational mechanism//ATP binding//hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0045263//GO:0005739//GO:0033178//GO:0045259//GO:0009535//GO:0045261 proton-transporting ATP synthase complex, coupling factor F(o)//mitochondrion//proton-transporting two-sector ATPase complex, catalytic domain//proton-transporting ATP synthase complex//chloroplast thylakoid membrane//proton-transporting ATP synthase complex, catalytic core F(1) KOG1353 F0F1-type ATP synthase, alpha subunit Cluster-9756.0 BF_2 4.00 0.94 465 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9763.0 BF_2 3.00 0.53 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9768.0 BF_2 8.00 14.60 289 469664513 AGH70211.1 249 2.5e-19 40S ribosomal protein S28 [Placozoa sp. H4] 256709225 GQ422265.1 78 5.12581e-31 Diplogastrellus gracilis small subunit ribosomal protein 28 (rps-28) mRNA, partial cds K02979 RP-S28e, RPS28 small subunit ribosomal protein S28e http://www.genome.jp/dbget-bin/www_bget?ko:K02979 P62857 229 2.2e-18 40S ribosomal protein S28 OS=Homo sapiens GN=RPS28 PE=1 SV=1 PF01200 Ribosomal protein S28e GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840//GO:0005622 ribosome//intracellular KOG3502 40S ribosomal protein S28 Cluster-9770.0 BF_2 15.00 1.18 818 264681147 YP_003288841.1 480 1.2e-45 ATP synthase F0 subunit 6 [Stylochyrus rarior]>gi|262212647|gb|ACY35978.1| ATP synthase F0 subunit 6 [Stylochyrus rarior] 657406588 KJ647171.1 105 1.53633e-45 Apodemia mormo voucher AP1234 mitochondrion, complete genome K02126 ATPeF0A, MTATP6, ATP6 F-type H+-transporting ATPase subunit a http://www.genome.jp/dbget-bin/www_bget?ko:K02126 O99821 385 5.0e-36 ATP synthase subunit a OS=Rhipicephalus sanguineus GN=ATP6 PE=3 SV=1 -- -- -- -- -- -- GO:0016020//GO:0005739 membrane//mitochondrion KOG4665 ATP synthase F0 subunit 6 and related proteins Cluster-9772.0 BF_2 6.00 0.73 631 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF02845 CUE domain -- -- GO:0005515 protein binding -- -- -- -- Cluster-9774.0 BF_2 3.00 0.37 622 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9775.0 BF_2 3.00 0.41 596 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9782.0 BF_2 4.00 0.50 619 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9785.0 BF_2 3.00 0.63 485 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- PF15761 Immortalisation up-regulated protein -- -- -- -- GO:0005634 nucleus -- -- Cluster-9790.0 BF_2 4.00 0.97 459 -- -- -- -- -- 46801324 AJ507061.2 33 8.83678e-06 Scutigera coleoptrata complete mitochondrial genome -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9791.0 BF_2 2.00 0.51 452 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9794.0 BF_2 3.00 0.65 480 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9804.0 BF_2 2.00 0.34 534 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9809.0 BF_2 5.00 0.41 797 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9811.0 BF_2 2.00 0.49 457 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9813.0 BF_2 7.00 0.35 1132 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9814.0 BF_2 13.00 0.47 1450 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9823.0 BF_2 1.00 0.39 392 241681373 XP_002411588.1 509 2.4e-49 ribosomal protein L27A, putative [Ixodes scapularis]>gi|67083893|gb|AAY66881.1| ribosomal protein L27A [Ixodes scapularis]>gi|215504328|gb|EEC13822.1| ribosomal protein L27A, putative [Ixodes scapularis] 157690691 BN001035.1 65 1.21137e-23 TPA_exp: Spadella cephaloptera mRNA for putative 60S ribosomal protein L27a isoform 2 (rpl27a.2 gene) K02900 RP-L27Ae, RPL27A large subunit ribosomal protein L27Ae http://www.genome.jp/dbget-bin/www_bget?ko:K02900 P18445 464 1.6e-45 60S ribosomal protein L27a OS=Rattus norvegicus GN=Rpl27a PE=1 SV=3 -- -- GO:0042254//GO:0006412 ribosome biogenesis//translation GO:0003735 structural constituent of ribosome GO:0005840 ribosome KOG1742 60s ribosomal protein L15/L27 Cluster-9826.0 BF_2 5.00 0.81 544 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9832.0 BF_2 7.00 0.78 664 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9849.0 BF_2 2.00 0.45 473 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9850.0 BF_2 13.00 0.98 840 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9851.0 BF_2 2.00 0.34 536 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9864.0 BF_2 5.00 0.97 503 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9868.0 BF_2 3.00 0.39 606 270010927 EFA07375.1 350 1.0e-30 hypothetical protein TcasGA2_TC016350 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- PF03067 Chitin binding domain -- -- -- -- GO:0019028 viral capsid -- -- Cluster-9869.0 BF_2 1.00 0.32 416 32490483 BAB13739.2 150 1.1e-07 crustocalcin [Marsupenaeus japonicus] 387598107 AC245517.3 54 1.68363e-17 Homo sapiens BAC clone CH17-424L4 from chromosome 22, complete sequence -- -- -- -- P81589 143 2.9e-08 Cuticle protein CP575 OS=Cancer pagurus PE=1 SV=1 PF00379 Insect cuticle protein -- -- GO:0042302 structural constituent of cuticle -- -- -- -- Cluster-9870.0 BF_2 1.00 0.53 363 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9878.0 BF_2 2.00 0.33 539 225710700 ACO11196.1 581 1.5e-57 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial precursor [Caligus rogercresseyi] 20379934 BC028833.1 59 3.68739e-20 Mus musculus hydroxyacyl-Coenzyme A dehydrogenase, mRNA (cDNA clone IMAGE:5136060), partial cds K00022 HADH 3-hydroxyacyl-CoA dehydrogenase http://www.genome.jp/dbget-bin/www_bget?ko:K00022 Q16836 517 1.6e-51 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial OS=Homo sapiens GN=HADH PE=1 SV=3 PF02737//PF03721//PF03446//PF01210 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain//UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain//NAD binding domain of 6-phosphogluconate dehydrogenase//NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus GO:0006552//GO:0006631//GO:0046168//GO:0006633//GO:0006098//GO:0018874//GO:0006554//GO:0055114//GO:0006568//GO:0019521//GO:0006574//GO:0006550 leucine catabolic process//fatty acid metabolic process//glycerol-3-phosphate catabolic process//fatty acid biosynthetic process//pentose-phosphate shunt//benzoate metabolic process//lysine catabolic process//oxidation-reduction process//tryptophan metabolic process//D-gluconate metabolic process//valine catabolic process//isoleucine catabolic process GO:0016491//GO:0051287//GO:0003857//GO:0004616//GO:0016616 oxidoreductase activity//NAD binding//3-hydroxyacyl-CoA dehydrogenase activity//phosphogluconate dehydrogenase (decarboxylating) activity//oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor -- -- KOG2304 3-hydroxyacyl-CoA dehydrogenase Cluster-9880.0 BF_2 4.00 1.32 413 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9887.0 BF_2 2.00 0.45 472 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9888.0 BF_2 4.77 1.24 448 270015247 EFA11695.1 253 1.3e-19 hypothetical protein TcasGA2_TC002152 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9892.0 BF_2 4.00 0.74 513 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9914.0 BF_2 5.00 1.19 463 -- -- -- -- -- 761231856 KM881642.1 463 0 Oryza longistaminata isolate 81953 chloroplast, complete genome -- -- -- -- P0C378 371 1.2e-34 Translation initiation factor IF-1, chloroplastic OS=Oryza sativa GN=infA PE=3 SV=1 PF00575//PF01176 S1 RNA binding domain//Translation initiation factor 1A / IF-1 GO:0006413//GO:0006446 translational initiation//regulation of translational initiation GO:0003723//GO:0003743//GO:0003676 RNA binding//translation initiation factor activity//nucleic acid binding GO:0005840 ribosome -- -- Cluster-9915.0 BF_2 7.00 0.68 716 270007709 EFA04157.1 563 2.4e-55 hypothetical protein TcasGA2_TC014403 [Tribolium castaneum] -- -- -- -- -- K05673 ABCC4 ATP-binding cassette, subfamily C (CFTR/MRP), member 4 http://www.genome.jp/dbget-bin/www_bget?ko:K05673 O15439 405 2.1e-38 Multidrug resistance-associated protein 4 OS=Homo sapiens GN=ABCC4 PE=1 SV=3 PF00005 ABC transporter -- -- GO:0016887//GO:0005524 ATPase activity//ATP binding -- -- -- -- Cluster-9916.0 BF_2 5.00 0.49 716 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9917.0 BF_2 1.00 1.26 306 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9940.5 BF_2 1.00 0.94 322 -- -- -- -- -- 20162 Z11475.1 237 2.37032e-119 O.sativa 5S DNA -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9942.0 BF_2 2.00 0.40 496 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9943.0 BF_2 10.00 0.38 1397 675387258 KFM80155.1 1091 2.8e-116 Phytanoyl-CoA dioxygenase, peroxisomal, partial [Stegodyphus mimosarum] 558111919 XM_006085807.1 52 7.74011e-16 PREDICTED: Myotis lucifugus phytanoyl-CoA 2-hydroxylase (PHYH), mRNA K00477 PHYH phytanoyl-CoA hydroxylase http://www.genome.jp/dbget-bin/www_bget?ko:K00477 O14832 947 5.8e-101 Phytanoyl-CoA dioxygenase, peroxisomal OS=Homo sapiens GN=PHYH PE=1 SV=1 -- -- -- -- -- -- -- -- -- -- Cluster-9944.1 BF_2 2.00 0.67 412 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9955.0 BF_2 2.00 0.35 526 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9957.0 BF_2 2.00 0.49 459 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9960.0 BF_2 4.00 0.36 757 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9972.0 BF_2 2.00 0.40 494 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9977.0 BF_2 17.00 0.44 1919 91094721 XP_970562.1 1689 1.8e-185 PREDICTED: solute carrier family 22 member 1 [Tribolium castaneum]>gi|270016527|gb|EFA12973.1| hypothetical protein TcasGA2_TC010997 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- Q9VCA2 761 2.9e-79 Organic cation transporter protein OS=Drosophila melanogaster GN=Orct PE=1 SV=1 PF07690//PF00083 Major Facilitator Superfamily//Sugar (and other) transporter GO:0055085//GO:0006810 transmembrane transport//transport GO:0022857//GO:0005215 transmembrane transporter activity//transporter activity GO:0016021//GO:0016020 integral component of membrane//membrane KOG0255 Synaptic vesicle transporter SVOP and related transporters (major facilitator superfamily) Cluster-9983.1 BF_2 1.00 0.53 363 91091514 XP_969527.1 148 1.6e-07 PREDICTED: transmembrane protein 181 [Tribolium castaneum]>gi|642936877|ref|XP_008194310.1| PREDICTED: transmembrane protein 181 [Tribolium castaneum]>gi|270000929|gb|EEZ97376.1| hypothetical protein TcasGA2_TC011201 [Tribolium castaneum] -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9984.0 BF_2 2.00 0.36 520 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9990.0 BF_2 9.00 0.96 678 -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- -- Cluster-9991.0 BF_2 3.00 0.40 603 321457133 EFX68226.1 659 1.5e-66 structural maintenance of chromosome protein 3 [Daphnia pulex] -- -- -- -- -- K06669 SMC3, CSPG6 structural maintenance of chromosome 3 (chondroitin sulfate proteoglycan 6) http://www.genome.jp/dbget-bin/www_bget?ko:K06669 O93309 492 1.4e-48 Structural maintenance of chromosomes protein 3 OS=Xenopus laevis GN=smc3 PE=1 SV=2 PF09432//PF00769//PF04136//PF02059//PF06156//PF08988 Tho complex subunit THP2//Ezrin/radixin/moesin family//Sec34-like family//Interleukin-3//Protein of unknown function (DUF972)//Type III secretion system, cytoplasmic E component of needle GO:0006406//GO:0006886//GO:0009405//GO:0007165//GO:0006260//GO:0006955//GO:0008283//GO:0006368//GO:0040007 mRNA export from nucleus//intracellular protein transport//pathogenesis//signal transduction//DNA replication//immune response//cell proliferation//transcription elongation from RNA polymerase II promoter//growth GO:0005135//GO:0008083//GO:0008092 interleukin-3 receptor binding//growth factor activity//cytoskeletal protein binding GO:0019898//GO:0005737//GO:0005801//GO:0016020//GO:0005894//GO:0005576//GO:0000446 extrinsic component of membrane//cytoplasm//cis-Golgi network//membrane//interleukin-3 receptor complex//extracellular region//nucleoplasmic THO complex KOG0964 Structural maintenance of chromosome protein 3 (sister chromatid cohesion complex Cohesin, subunit SMC3) Cluster-9994.0 BF_2 49.00 2.24 1203 761380059 YP_009121383.1 1325 1.8e-143 cytochrome c oxidase subunit 1 (mitochondrion) [Thecamonas trahens]>gi|751130546|gb|AJF36624.1| cytochrome c oxidase subunit 1 (mitochondrion) [Thecamonas trahens] 353685281 JN861112.1 1200 0 Oryza sativa Indica Group mitochondrion, complete genome K02256 COX1 cytochrome c oxidase subunit 1 http://www.genome.jp/dbget-bin/www_bget?ko:K02256 P26856 1432 2.9e-157 Cytochrome c oxidase subunit 1 OS=Marchantia polymorpha GN=COX1 PE=3 SV=2 PF00115 Cytochrome C and Quinol oxidase polypeptide I GO:0009060//GO:0006123//GO:0015992//GO:0055114//GO:0006118 aerobic respiration//mitochondrial electron transport, cytochrome c to oxygen//proton transport//oxidation-reduction process//obsolete electron transport GO:0005506//GO:0020037//GO:0004129//GO:0009055 iron ion binding//heme binding//cytochrome-c oxidase activity//electron carrier activity GO:0045277//GO:0016021 respiratory chain complex IV//integral component of membrane KOG4769 Cytochrome c oxidase, subunit I